Miracle-dz/UniFAR-FTUs huggingface dataset:
Microcephaly-associated WDR62 mutations hamper Golgi apparatus-to-spindle pole shuttling in human neural progenitors

WDR62 is a spindle pole-associated scaffold protein with pleiotropic functions during corticogenesis. Recessive mutations in WDR62 are associated with structural brain abnormalities and account for the second most common cause of autosomal recessive primary microcephaly (MCPH), indicating WDR62 as a critical hub for human brain development. Here, we investigated a C-terminal truncating mutation (D955AfsX112) in WDR62 using induced pluripotent stem cells (iPSCs) obtained from a patient with MCPH2. We generated neuroepithelial stem (NES) cells and cerebro-cortical progenitors and neurons from patient-derived and isogenic retro-mutated iPSC lines. We found that WDR62 dysfunction resulted in impaired cell cycle progression and alterations of the neurogenic trajectories of iPSC neuroderivatives. Moreover, we report WDR62 localization at the Golgi apparatus during interphase, both in human neural progenitors in vitro and in human fetal brain tissue. WDR62 shuttling from the Golgi apparatus to spindle poles is dynamic and microtubule-dependent. Impairment of WDR62 function and localization results in severe neurodevelopmental abnormalities, thus delineating new mechanisms in MCPH etiology.
Proceedings of the Jepson Undergraduate Conference on Proceedings of the Jepson Undergraduate Conference on International Economics International Economics Influence of GDP per Capita on Birth Rates Influence of GDP per Capita on Birth Rates

This paper aims to explore the relationship between a country’s birth rate and GDP per capita. I use cross-sectional data for 108 countries from the CIA’s World Factbook and The World Bank. From the research, it is clear that countries with lower infant mortality rates and higher levels of female education have lower birth rates, but the impact of GDP per capita remains ambiguous. It appears the relationship between GDP per capita and birth rates may be mediated through factors such as female empowerment, better healthcare, contraception availability, and family planning resources.
The Effect of Inferred Explanations in a Bayesian Theory of Pronominal Reference

Background and Study Kehler & Rohde (2013) posit a Bayesian analysis of pronoun use whereby biases towards referents of pronouns (P (referent|pronoun)) are determined by combining the prior probability that a referent will get mentioned next (‘next-mention’ biases; P (referent)) and the likelihood that a pronoun will be used to mention that referent (P (pronoun|referent)). Crucially, the factors that condition these terms are different: Next-mention biases are determined primarily by semanticallydriven factors (e.g., coherence relations), whereas the production bias is sensitive primarily to information structure and grammatical role (e.g., favoring a greater rate of pronominalizing mentions of subject referents compared to other roles; Rohde 2008, Fukumura & van Gompel 2010, Rohde & Kehler 2013). We examine the model using data from a passage completion task. The design employs a manipulation that utilizes the fact that relative clauses (RCs) attached to direct objects can be inferred to provide explanations of the matrix event (Rohde et al 2011). RC type is manipulated as in (1a-b):
Arithmetic of hyperbolic 3-manifolds

This note is an elaboration of the ideas and intuitions of Grothendieck and Weil concerning the "arithmetic topology". Given 3-dimensional manifold M fibering over the circle we introduce an real quadratic number field K with discriminant d, where d>0 is an integer number uniquely determined by M. The idea is to relate geometry of M to the arithmetic of field K. On this way, we show that Vol M is a limit density of ideals of given norm in the field K (Dirichlet density). The second statement says that the number of cusp points of manifold M is equal to the class number of the field K. It is remarkable that both of the invariants can be explicitly calculated for the concrete values of discriminant d. Our approach is based on the K-theory of noncommutative C*-algebras coming from measured foliations and geodesic laminations studied by Thurston et al. We apply the elaborated technique to solve the Poincare conjecture for given class of manifolds.
Structural Design for Enhanced Light Extraction in Light Emitting Diodes with Nano-patterned n-GaN

We analyzed the structure of light-emitting diode (LED) chips, where nano-sized cylindrical patterns are distributed inside the n-GaN region, by using a three-dimensional finite-difference timedomain method. Using the simulated data, we optimized the design of the structure to enhance the light extraction efficiency. We varied the diameter, density, height, and refractive index of the nano-patterns embedded in the LEDs and found the optimized parameters. Our analyses and design results are applicable to the fabrication of LEDs for enhanced light extraction.
CORRIGENDUM: Unconstrained N = 2 matter, Yang-Mills and supergravity theories in harmonic superspace

A new approach to N=2 supersymmetry based on the concept of harmonic superspace is proposed and is used to give an unconstrained superfield geometric description of N=2 super Yang-Mills and supergravity theories as well as of matter N=2 hypermultiplets. The harmonic N=2 superspace has an independent coordinates, in addition to the usual ones, the isospinor harmonics ui+or- on the sphere SU(2)/U(1). The role of ui+or- is to relate the SU(2) group realised on the component fields to a U(1) group acting on the relevant superfields. Their introduction makes it possible to SU(2)-covariantise the notion of Grassmann analyticity. Crucial for the construction is the existence of an analytic subspace of the general harmonic N=2 superspace. The hypermultiplet superfields and the true prepotentials (pre-prepotentials) of N=2 super Yang-Mills and supergravity are unconstrained superfunctions over this analytic subspace. The pre-prepotentials have a clear geometric interpretation as gauge connections with respect to the internal SU(2)/U(1) directions. A radically new feature arises: the number of gauge and auxiliary degrees of freedom becomes infinite while the number of physical degrees of freedom remains finite. Other new results are the massive N=2 Yang-Mills theory and various off-shell self-interactions of hypermultiplets. The propagators for matter and Yang-Mills superfields are given.
Theory of wing sections of arbitrary shape

This report presents a solution of the problem of the theoretical flow of a frictionless incompressible fluid past airfoils of arbitrary forms. The velocity of the 2-dimensional flow is explicitly expressed for any point of the surface, and for any orientation, by an exact expression containing a number of parameters which are functions of the form only and which may be evaluated by convenient graphical methods. The method is particularly simple and convenient for bodies of streamline forms. The results have been applied to typical airfoils and compared with experimental data.
Investigation and visualization of resolution theorems in self modeling curve resolution (SMCR) methods

Different approaches have been proposed during recent years to improve the solutions obtained by multivariate curve resolution methods, among them studies on circumstances that result in unique answers are of particular importance. Three so‐called resolution theorems proposed by Rolf Manne comprehensively discuss and survey these conditions. Despite the importance of these theorems, they have not attracted much attention in the literature. In this work, we have returned to the resolution theorems by using visualization tools for calculation and demonstration the area of feasible solutions in a simulated three component system. The effect of selectivity and local rank constraints on rotational ambiguity in the results of self modeling curve resolution methods is the focus. Copyright © 2013 John Wiley & Sons, Ltd.
Startups, SMEs and Institutional Arrangements in the Internet of Startups, SMEs and Institutional Arrangements in the Internet of Things Innovation Ecosystem in Brazil Things Innovation Ecosystem in Brazil

Startups and Small and Medium Enterprises (SMEs), despite their importance to the local economy, generally have limited resources and face significant barriers to innovate and grow, such as lack of access to knowledge, human resources, and efficient forms of financing. This paper reports preliminary results of a research project that aims to analyze the institutional arrangements in the Brazilian Internet of Things (IoT) innovation ecosystem and how these arrangements support the innovation by startups and SMEs. The research method is a longitudinal case study. The preliminary research results show the main groups of actors and resources involved in the IoT innovation ecosystem in Brazil. The results also suggest that the institutional arrangements in this ecosystem usually favors the big players; several controversies exist regarding key elements of the institutional pillars elements related to the IoT development in the country. Besides, the knowledge diffusion about the IoT and its potential is still needed.
Micro- and nanobiosensors—state of the art and trends

Recent progress in microsystem technologies for creating small, integrated and reliable microelectronic devices and microtransducers in combination with biological sensing elements has raised the expectation to get a comprehensive insight into dynamic cellular metabolic events and subsequently a complete understanding of the metabolism of human biology. Such micro- and nanobiosensor tools in combination with appropriate microfluidics enable the simultaneous description and moreover monitoring of gene, protein expression and metabolic states in a biosystem. This knowledge will lead to new future therapies and pharmaceutical treatments. Furthermore, with such methods and microdevices a new direct combination of diagnostics and immediately starting therapy can be established which is called theranostic. There are a lot of challenging problems to be overcome to reach this goal: microsystems monitoring of physical parameters in biological systems is well established, whereas chemo- and biosensors are available for only a few parameters and mainly as in vitro devices. Gene arrays entered the research market but are up to now not in clinical practice. Protein arrays are in a developmental state with promising results, but far from a mature reproducible state. For getting insights into metabolic events intra- and extracellularly, some new and promising technologies are under research and will undoubtedly revolutionize systems biology but only in the longer run. As a conclusion, it can be stated that new methods stemming from microelectronics and biological technologies are now entering the world of chemical and biological analytics as well as clinics to offer clinicians new theranostic tools in the future.
The-impact of fishing disturbance on benthic nutrient regeneration and flux rate.

Nitrogen products are often thought to be a major limiting factor for photosynthesis by marine primary producers, ultimately, therefore, fisheries yield is dependent on the amounts of new and regenerated nutrients within the system. It is generally held that greater than 90% of marine primary production is remineralised within the marine system. However, the contribution to this figure from sedimentary processes is less well understood. Little attention has, however, been paid to the potential change in nutrient regeneration dynamics and flux rates as a result of fishing disturbance of the seafloor. This study investigates benthic remineralisation and nutrient flux, including consideration of the role of benthic disturbance by fishing vessels. Two mesocosm systems containing sediment from an untrawled area of the North Sea were allowed to stabilise for two months prior to the study. One system was subjected to daily simulated trawl activity while the other system remained untrawled over a four day period. Flux chambers were used to gain data on concentration changes within the chambers for three hours following the disturbance. Results indicate that nutrient
Effect of bombardment with different ions (H, He, Ar) on ordering transformation of Fe48Pt52 films

Fe48Pt52 thin films with a thickness of 50 nm were deposited at room temperature before undergoing glow-discharge-induced ion bombardment at 300 °C for 1 h. The energy of the incident ions was adjusted by applying a radio-frequency bias (Vb) from 200 to 600 V. H2, He, and Ar were used as the working gases. Significant ordering enhancement was only found in the H-ion bombarded films. The coercivity of such films is greatly increased from 0.5 kOe, for the sample without any bias, to around 8 kOe at Vb=200–600 V, which result is similar to that for a film annealed at 400 °C in a vacuum. This result suggests that H-ion bombardment has the effect of a 100 °C increase in annealing temperature. Microstructural studies reveal that the average grain size of the H-ion bombarded films is about 30 nm, which is much smaller than that of 400 °C-annealed films. The film thickness of He-ion bombarded samples decreases linearly as Vb increases because of the intensive sputtering effect. Under Ar-ion bombardment, most of t.
TRACE INEQUALITIES WITH APPLICATIONS TO ORTHOGONAL REGRESSION AND MATRIX NEARNESS PROBLEMS

Matrix trace inequalities are finding increased use in many areas such as analysis, where they can be used to generalise several well known classical inequalities, and computational statistics, where they can be applied, for example, to data fitting problems. In this paper we give simple proofs of two useful matrix trace inequalities and provide applications to orthogonal regression and matrix nearness problems.
Stinking Consciousness! 1

: Contemporary neuroscientific theories of consciousness are typically based on the study of vision and have neglected olfac tion. Several of these (e.g. Global Workspace Theories, the Information Integration theory, and the various theories offered by Crick and Koch) claim that a thalamic relay is necessary for olfactory consciousness. Studies on olfaction and the olfactory system’s anatomical structure show this claim to be incorrect, thus showing these theories to be either false or inadequate as general and comprehensive accounts of consciousness. Attempts to rescue these theories by claim-ing that there is a structure in the olfactory system that is functionally equivalent to the thalamus in the visual system, such as the olfactory bulb or the olfactory cortex, are also shown to fail. If we wish to understand consciousness, we have to wake up and smell it.
Theory of Dielectrics: Dielectric Constant and Dielectric Loss

Physicists, chemists, and electrical engineers are all interested in the properties of dielectric materials, though with different purposes in mind. This book is intended to give a systematic account of the theory of dielectric properties, and thus to provide a background against which applications can be made. It seldom requires the reader to have a knowledge of mathematics greater than is implied by an acquaintance with calculus, and the reader is assumed to have a certain elementary knowledge of atomic and molecular physics, statistical mechanics, and electrostatics.
Pairing and superfluidity in strongly interacting Fermi gases

This thesis describes experiments with superfluid spin mixtures of ultracold fermionic 6 Li atoms. The properties of the strongly interacting gas are studied in the crossover regime between Bose-Einstein condensation (BEC) of two-body bound molecules and a BardeenCooper-Schrieffer (BCS) superfluid of pairs bound by many-body interactions. We obtain the homogeneous phase diagram of the two-component gas with resonant interactions. As a function of temperature and spin polarization the phase diagram shows first and second order phase transitions that merge at a tricritical point. At zero temperature a first order phase transition from a superfluid with equal spin populations to a mixed normal phase is observed at a critical spin polarization known as the Chandrasekhar-Clogston limit of superfluidity. Pairing correlations in the superfluid and normal phase are studied with radio-frequency (rf) spectroscopy. A signature of strong correlations is observed above the critical temperature but also at spin polarizations where superfluidity is quenched even at zero temperature. Significant limitations for the interpretation of these experiments due to final state interactions are overcome by the creation of new superfluid spin mixtures. The asymmetric rf dissociation spectra of the new mixture allow us to determine the spectroscopic pair size in the crossover regime. The size of the resonantly interacting pairs is found to be on the order of, but smaller than the interparticle spacing. Rf spectra of the majority component in an imbalanced system show a signature of thermally excited quasiparticles and by comparison to the minority spectra reveal changes in the nature of the binding as a function of spin polarization. Thesis Supervisor: Wolfgang Ketterle Title: John D. MacArthur Professor of Physics To my wife Alessandra, and my parents Angelika and Heiner
STRUČNI ČLANCI DRY EYE SYNDROME AND CATARACT SURGERY

SummaryIntroduction. Dry eye syndrome has become a common problem after ocular surgeries with a significant impact on the quality of life. Many patients, who have undergone cataract surgery, postop eratively developed dry eye symptoms. Dry eye syndrome is one of the risk factors associated with cataract surgery. Material and Methods. The prospective study included 80 patients. We recorded the self-reported dry eye symptoms, the values of Schirmer test, tear breakup time, and best corrected visual acuity preoperatively, as well as 7 days and 1 month after the surgery. Results. A total of 80 patients were included in the study, 45 (56.2%) females and 35 (43.8%) males. The mean age of patients was 61.5 years (SD ± 6.2, range 57 - 70 years). The best corrected visual acuity at the time of surgery was 0.4 or less in 70 patients (87.5%). Most patients re ported a significant improvement in visual acuity after surgery; 68 (85%) eyes achieved a best corrected visual acuity of 0.5 or higher (median 0.7; range 0.5 - 1.0). The mean tear breaking time in cata ract patients before surgery was 12.4 sec, 7 days after the surgery it was 8.2 sec (p < 0.05) and 1 moth after the surgery 11.1 sec. The majority of patients had mild (47.5%) and moderate (33.75%) Schirmer test values. Dry eye with wetting < 5 mm after 5 minutes was found in 16.2% of patients before cataract surgery; 7 days after the surgery (p < 0.05) it was found in 23.75% of patients and one monht after surgery 11.1 sec. A foreign body sensation and watery eye were the most reported symptoms before cataract surgery. Seven days after the surgery foreign body sensation was present in 48.75% and watery eyes in 40% of patients. Conclusion. dry eye symptoms cataract surgery age. Self reported dry eye problems are more common in patients with lower Schirmer test and best corrected visual acu ity values before cataract surgery. Patients with concomitant dry eye disease require preoperative and postoperative treatment of dry eye to prevent aggravation of the existing symptoms that may affect the visual outcome after cataract surgery.
Axion-Dilaton Quantum String Cosmology for Flux Compactification and its Symmetry Breaking

The Wheeler-De Witt equation of type IIB quantum string cosmology compactified with constant internal H-fluxes on a 6-torus, whose volume modulus is frozen, is solved under the WKB approximation. The spontaneous symmetry breaking of the S-duality group by H-fluxes is also examined.
AIS Electronic Library (AISeL) AIS Electronic Library (AISeL)

In recent years, social media platforms start adopting influencer marketing to increase consumer retention rates and generate revenues. In this study, we explore how consumers perceive and react to influencer marketing and commercialization of social media platform. Adopting a qualitative approach, we interview fourteen users/influencers of a popular social media platform. Data analysis reveals a new type of advertisement in influencer marketing, i.e., blurred-boundary advertisements, which blur the boundary between sponsored advertisements and genuine electronic word of mouth (eWoM). We also find that a portion of social media users are establishing hybrid identities, both as consumers and influencers. Hybrid identity users show more tolerance towards advertisements than common users. Common users accept advertisements in influencer marketing, but prefer explicit advertisements to blurred-boundary advertisements. Blurred-boundary advertisements may damage c onsumers’ trust in influencers and in social media platforms. Our findings show the complexity in influencer marketing and commercialization of social media platforms.
Planar Dirac Fermions in External Electromagnetic Fields

We study the electron propagator in two spatial dimensions in the presence of external electromagnetic fields, this is, we focus in (2+1)-dimensional quantum electrodynamics (QED), where a third spatial dimension is suppressed. This is not a mere theoretical simplification, and we explain ourselves: back in time, some twenty years ago, it was shown that the low-energy effective theory of graphene in a tight-binding approach is the theory of two species of massless Dirac electrons in a (2+1)-dimensional Minkowski spacetime, each on a different irreducible representation of the Clifford algebra. The isolation of graphene samples in 2004 and 2005, has given rise to the new paradigm of relativistic condensed matter, bringing a new boost, both theoretical and experimental, to the matching of common interests of the condensedmatter and high energy physics communities. Thus, themassless limit of our findings is of direct relevance in this subject. We assume the electrons moving in a magnetic field alone pointing perpendicularly to their plane of motion. We first develop the general case and then, we present a couple of examples: themotion of electrons in a uniformmagnetic field, which is a canonical example to present the Ritusmethod and the case of a static magnetic field which decays exponentially along the x-axis (Murguia et al, 2010; Raya & Reyes, 2010). There are many problems relating electrons in non-uniform magnetic fields of relevance in graphene. In particular, it has been established the possibility to confine quasiparticles in magnetic barriers (DeMartino et al, 2007; Ramezani et al, 2009). This could be feasible creating spatially inhomogeneous, but constant in time, magnetic fields depositing ferromagnetic layers over the substrate of a graphene sample layer (Reijniers et al, 2001). The physical properties of graphene make it a promising novel material to control the transport properties in nanodevices. It has been considered to be used in electronics and spintronics applications, like in single-electron transistors (Ponomarenko et al, 2008; Wu et al, 2008), in the so called magnetic edge states (Park & Sim, 2008), which may play an important role in the spin-polarized currents along magnetic domains, and in quantum dots and antidots magnetically confined. Moreover, the quantum Hall effect in graphene has been observed at room temperature (Novoselov et al, 2007), evidence which confirms the great potential of graphene as the material to be used in carbon-based electronic devices. The effects of the exponentially decaying magnetic field can hardly be considered with other approaches, 13