Miracle-dz/UniFAR-FTUs huggingface dataset:
motor, and cognitive skills of girls with congenital hypothyroidism treated from the neonatal period

interests: nothing to declare. ABSTRACT Objective: To compare the performance in gross motor, fine motor-adaptive, language, cognitive and personal-social development skills of girls with a mean age of 36 to 71 months with Congenital Hypothyroidism treated from the neonatal period with that of their peers without thyroid alterations. Methods: The participants included in the study were 30 children aged between 36 and 70 months divided into two groups paired for chronological age and socioeconomic status: 15 girls diagnosed with Congenital Hypothyroidism – Experimental Group (EG) and 15 girls without thyroid changes – Control Group (CG). The following assessment instruments were used: Interview with parents, Peabody Picture Vocabulary Test - Revised (PPVT-R), and Denver Developmental Screening Test - 2 nd edition (DDST-II). Psychological testing of intellectual functioning was conducted with application of the Stanford-Binet Intelligence Scale (SBIS). The descriptive statistical analysis was performed using Student’s t-test and the Mann-Whitney test at a significance level of 5% (p<0.05). Results: Comparison of the PPVT-R and SBIS results showed a statistically significant difference between the EG and CG. Comparison of the DDST-II results showed a statistically significant difference between the groups for the fine motor-adaptive, language and gross motor areas. Conclusion: The present study confirms that Congenital Hypothyroidism affects child development, even when children are diagnosed and treated early, leading to alterations that can impair their motor,
Primary chemotherapy : A better overall therapeutic option for patients with breast cancer

More than a century ago, William Halsted synthesized the surgical concepts that culminated in his description of the radical mastectomy. This doctrine was based on the conviction that breast cancer was a locoregional disease, and therefore, a radical surgical procedure with wide tumor-free margins could lead to eradication of all cancer cells and cure breast cancer. However, locoregional therapy alone has proved to be inadequate in curing many patients with early breast cancer. Distant micro metastases may be present in 30% to 90% of patients with primary breast cancer. The high propensity of early breast cancer to generate distant micro metastases was recognized in the early 1970s. Based on these theoretical considerations, adjuvant systemic chemotherapy and or hormonotherapy was initially introduced in the treatment of patients with high risk (stage II—Ilia) breast cancer, and more recently, in patients with stage I breast cancer. The long-term value of systemic adjuvant therapy in patients with breast cancer is clearly established [1, 2].
Integrating Data Clustering and Visualization for the Analysis of 3D Gene Expression Data

The recent development of methods for extracting precise measurements of spatial gene expression patterns from three-dimensional (3D) image data opens the way for new analyses of the complex gene regulatory networks controlling animal development. We present an integrated visualization and analysis framework that supports user-guided data clustering to aid exploration of these new complex data sets. The interplay of data visualization and clustering-based data classification leads to improved visualization and enables a more detailed analysis than previously possible. We discuss 1) the integration of data clustering and visualization into one framework, 2) the application of data clustering to 3D gene expression data, 3) the evaluation of the number of clusters k in the context of 3D gene expression clustering, and 4) the improvement of overall analysis quality via dedicated postprocessing of clustering results based on visualization. We discuss the use of this framework to objectively define spatial pattern boundaries and temporal profiles of genes and to analyze how mRNA patterns are controlled by their regulatory transcription factors.
Reconciling Dimensional and Categorical Models of Autism Heterogeneity: a Brain Connectomics & Behavioral Study

Background Heterogeneity in autism spectrum disorder (ASD) has hindered the development of biomarkers, thus motivating subtyping efforts. Most subtyping studies divide ASD individuals into non-overlapping (categorical) subgroups. However, continuous inter-individual variation in ASD suggests the need for a dimensional approach. Methods A Bayesian model was employed to decompose resting-state functional connectivity (RSFC) of ASD individuals into multiple abnormal RSFC patterns, i.e., categorical subtypes henceforth referred to as “factors”. Importantly, the model allowed each individual to express one or more factors to varying degrees (dimensional subtyping). The model was applied to 306 ASD individuals (age 5.2-57 years) from two multisite repositories. Posthoc analyses associated factors with symptoms and demographics. Results Analyses yielded three factors with dissociable whole-brain hypo/hyper RSFC patterns. Most participants expressed multiple (categorical) factors, suggestive of a mosaic of subtypes within individuals. All factors shared abnormal RSFC involving the default network, but the directionality (hypo/hyper RSFC) differed across factors. Factor 1 was associated with core ASD symptoms, while factor 2 was associated with comorbid symptoms. Older males preferentially expressed factor 3. Factors were robust across multiple control analyses and not associated with IQ, nor head motion. Conclusions There exist at least three ASD factors with dissociable patterns of whole-brain RSFC, behaviors and demographics. Heterogeneous default network hypo/hyper RSFC across the factors might explain previously reported inconsistencies. The factors differentiated between core ASD and comorbid symptoms - a less appreciated domain of heterogeneity in ASD. These factors are co-expressed in ASD individuals with different degrees, thus reconciling categorical and dimensional perspectives of ASD heterogeneity.
Widar3.0: Zero-Effort Cross-Domain Gesture Recognition With Wi-Fi

With the development of signal processing technology, the ubiquitous Wi-Fi devices open an unprecedented opportunity to solve the challenging human gesture recognition problem by learning motion representations from wireless signals. Wi-Fi-based gesture recognition systems, although yield good performance on specific data domains, are still practically difficult to be used without explicit adaptation efforts to new domains. Various pioneering approaches have been proposed to resolve this contradiction but extra training efforts are still necessary for either data collection or model re-training when new data domains appear. To advance cross-domain recognition and achieve fully zero-effort recognition, we propose Widar3.0, a Wi-Fi-based zero-effort cross-domain gesture recognition system. The key insight of Widar3.0 is to derive and extract domain-independent features of human gestures at the lower signal level, which represent unique kinetic characteristics of gestures and are irrespective of domains. On this basis, we develop a one-fits-all general model that requires only one-time training but can adapt to different data domains. Experiments on various domain factors (i.e. environments, locations, and orientations of persons) demonstrate the accuracy of 92.7% for in-domain recognition and 82.6%-92.4% for cross-domain recognition without model re-training, outperforming the state-of-the-art solutions.
THEMICROWAVE ANISOTROPY PROBE (MAP )1 MISSION

The purpose of the MAP mission is to determine the geometry, content, and evolution of the universe via a 13 arc-min full-width-half-max (FWHM) resolution full sky map of the temperature anisotropy of the cosmic microwave background radiation with uncorrelated pixel noise, minimal systematic errors, multifrequency observations, and accurate calibration. These attributes were key factors in the success of NASA’sCosmic Background Explorer (COBE) mission, which made a Æ FWHM resolution full sky map, discovered temperature anisotropy, and characterized the fluctuations with two parameters, a power spectral index and a primordial amplitude. Following COBE considerable progress has been made in higher resolution measurements of the temperature anisotropy. With 45 times the sensitivity and 33 times the angular resolution of the COBE mission, MAP will vastly extend our knowledge of cosmology. MAP will measure the physics of the photon-baryon fluid at recombination. From this, MAP measurements will constrain models of structure formation, the geometry of the universe, and inflation. In this paper we present a pre-launch overview of the design and characteristics of the MAP mission. This information will be necessary for a full understanding of the MAP data and results, and will also be of interest to scientists involved in the design of future cosmic microwave background experiments and/or space science missions. Subject headings: cosmic microwave background, cosmology: observations, early universe, dark matter, space vehicles, space vehicles: instruments, instrumentation: detectors, telescopes
Treatment concepts for complications after resection and defect reconstruction of pelvic tumours

Background. Partial pelvic resection, internal hemipelvectomy or sacrectomy as a result of bone sarcoma is still challenging. No matter what kind of reconstruction is used, there is still a much higher rate of complications in pelvic surgery compared to sarcoma surgery of the long bones. Objectives.We describe the most common complications in pelvic sarcoma surgery and specific complications related to the reconstruction method. Handling strategies for these complications are specified. Methods.We performed a literature search and report our own experiences in the troubleshooting of pelvic surgery-related complications to gain an up-to-date overview of the state-of-the-art in management strategies. Results. Prospective randomized trials or meta-analyses on this topic are lacking. The literature search depicted that, besides local recurrence, deep infection after reconstruction is the most serious complication. An early revision with radical debridement has to be performed in order to save the reconstruction. In the case of a deep infection, the removal of all implants with a total loss of the reconstruction is often unavoidable. Therefore, an individualized risk-benefit analysis prior to surgery with respect to the type of reconstruction, or no reconstruction at all (hip transposition), together with the patient is advisable. Conclusions. Complications—especially infections—after hemipelvectomy or sacrectomy are common. In the case of infection, in some cases, an early revision is the only chance to prevent a reconstruction from explantation.
Endogenous inhibitor proteins that connect Ser/Thr kinases and phosphatases in cell signaling

Protein phosphatase activity acts as a primary determinant of the extent and duration of phosphorylation of cellular proteins in response to physiological stimuli. Ser/Thr protein phosphatase‐1 (PP1) belongs to the PPP superfamily, and is associated with regulatory subunits that confer substrate specificity, allosteric regulation, and subcellular compartmentalization. In addition, all eukaryotic cells contain multiple heat‐stable proteins that originally were thought to inhibit phosphatase catalytic subunits released from the regulatory subunits, as a fail‐safe mechanism. However, discovery of C‐kinase‐activated PP1 inhibitor, Mr of 17 kDa (CPI‐17) required fresh thinking about the endogenous inhibitors as specific regulators of particular phosphatase complexes, acting in addition to, not instead of, regulatory subunits. The cellular actions of the endogenous inhibitors are controlled by phosphorylation, connecting them to kinase pathways. More recent progress has unveiled additional functions of PP1 inhibitor‐2 (I‐2), including regulation of protein kinases. Transcriptional mechanisms govern the expression levels of CPI‐17 in response to stimuli. If true for other inhibitor proteins, they have the potential of being diagnostic markers for pathological conditions. We discuss specific examples of PP1 inhibitor proteins regulating particular cellular functions and the rationale for incorporating phosphatase inhibitor proteins in development of new therapeutic strategies. © 2012 IUBMB IUBMB Life, IUBMB Life, 64(9): 732–739, 2012
Associations Between Outpatient Heart Failure Process-of-Care Measures and Mortality

Background— Assessment of the quality of care for outpatients with heart failure (HF) has focused on the development and use of process-based performance measures, with the supposition that these care process measures are associated with clinical outcomes. However, this association has not been evaluated for current and emerging outpatient HF measures. Methods and Results— Performance on 7 HF process measures (4 current and 3 emerging) and 2 summary measures was assessed at baseline in patients from 167 US outpatient cardiology practices with patients prospectively followed up for 24 months. Participants included 15 177 patients with reduced left ventricular ejection fraction (⩽35%) and chronic HF or post–myocardial infarction. Multivariable analyses were performed to assess the process-outcome relationship for each measure in eligible patients. Vital status was available for 11 621 patients. The mortality rate at 24 months was 22.1%. Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use, &bgr;-blocker use, anticoagulant therapy for atrial fibrillation, cardiac resynchronization therapy, implantable cardioverter-defibrillators, and HF education for eligible patients were each independently associated with improved 24-month survival, whereas aldosterone antagonist use was not. The all-or-none and composite care summary measures were also independently associated with improved survival. Each 10% improvement in composite care was associated with a 13% lower odds of 24-month mortality (adjusted odds ratio, 0.87; 95% confidence interval, 0.84 to 0.90; P<0.0001). Conclusions— Current and emerging outpatient HF process measures are positively associated with patient survival. These HF measures may be useful for assessing and improving HF care. Clinical Trial Registration— URL: http://www.clinicaltrials. gov. Unique identifier: NCT00303979.
THE NATURE STROKE STUDY; NASTRU: A RANDOMIZED CONTROLLED TRIAL OF NATURE-BASED POST-STROKE FATIGUE REHABILITATION

Anna María PÁLSDÓTTIR, PhD1, Kjerstin STIGMAR, PhD, RPT2, Bo NORRVING, MD, PhD3,4, Ingemar F. PETERSSON, MD, PhD5,6, Mikael ÅSTRÖM, Ph.Lic7 and Hélène PESSAH-RASMUSSEN, MD, PhD3,4 From the 1Swedish University of Agricultural Sciences (SLU), Department of Work Sciences, Business Economics and Environmental Psychology (AEM), Alnarp, 2Lund University, Department of Health Sciences, 3Lund University, Department of Clinical Sciences Lund, Neurology, Lund, 4Skåne University Hospital, Department of Neurology and Rehabilitation Medicine, and 5Lund University, Department of Clinical Sciences Lund, Orthopaedics, Lund, 6Skåne University Hospital and 7Skåne University Hospital, Data Analytics and Register Centrum, Region Skåne, Sweden
Potential Vorticity and Vertical Velocity at the Iceland-Færœs Front

Abstract Using data from high-resolution surveys of the Iceland- Faerœs Front, the authors have calculated synoptic maps of the geostrophic velocity, vorticity, and potential vorticity on isopycnal surfaces. The data have also been used to diagnose the vertical velocity field using the omega equation. These results are used to elucidate the dynamical processes occurring at the front. Across the front there was a large change in potential vorticity on the density surfaces σt = 27.4 − 27.6. Instability generates meanders that propagate eastward along the front. A cyclonic vortex was observed to break off from a meander. Within the vortex the magnitude of the relative vorticity was large (∼0.8 f), and the potential vorticity had high values similar to that of the water to the north of the front from which the vortex was derived. The eddy propagated northeastward relative to the underlying water resulting in large upward (downward) vertical velocities (of the order of 100 m d−1) ahead of (behind) the vortex.
Access to Basic Education in Ghana: The Evidence and the Issues

This review of educational development in Ghana has been developed to explore key issues in access to education, capture recent research, and to identify gaps in knowledge and understanding. This critical analytic review provides the basis for research which seeks to identify children who are excluded from basic education, establish the causes of their exclusion, and identify ways of ensuring that all children comnplete a full cycle of basic education successfully.
Glucose clearance and uptake is increased in the SOD1G93A mouse model of amyotrophic lateral sclerosis in an insulin-independent mechanism

Metabolic disturbances are associated with the progression of the neurodegenerative disorder, amyotrophic lateral sclerosis (ALS). In this study we aimed to elucidate deficits in energy homeostasis in the SOD1G93A mouse model of ALS and tissue specific changes in the periphery that underlie these perturbations. We found that at the mid-symptomatic stage of disease, SOD1G93A mice had an increase in oxygen consumption, and faster exogenous glucose uptake, despite no change in insulin sensitivity. Fasting glucose homeostasis was disturbed, along with changed concentrations in the glucoregulatory hormones, insulin and glucagon. Finally, the metabolic gene expression profile in the liver of SOD1G93A mice, and increase in glycogen stores indicate that glucose cannot be utilised efficiently. Overall, we found that glucose homeostasis and uptake is altered in SOD1G93A mice at the mid-symptomatic stage, potentially due to the increase in insulin-independent glucose uptake and disturbance in glucagon sensitivity. (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprint this version posted August 3, 2020. ; https://doi.org/10.1101/2020.08. 02.233411 doi: bioRxiv preprint
Riparian soil temperature modification of the relationship between flow and dissolved organic carbon concentration in a boreal stream

Discharge is often strongly correlated to the temporal variability of dissolved organic carbon concentrations ([DOC]) in watercourses. One recently proposed way to model this is the riparian flow‐concentration integration model (RIM) concept that accounts for the role of flow pathway control on [DOC] dynamics in streams. However, in boreal systems, there is also commonly a seasonal pattern, which cannot be explained by variability in discharge alone. The objectives with this study were to (1) demonstrate RIM as a tool for studying variability in stream water chemistry, (2) investigate factors related to stream water DOC variability, and (3) modify RIM to account for these factors. RIM was used with 14 years of daily discharge and almost 500 stream measurements of [DOC] from a forested boreal headwater stream. We used the calibrated RIM to account for discharge influences and then investigated variables that could be related to DOC variability (air and soil temperature, soil moisture, precipitation, antecedent flow and stream sulfate). Five alternative formulations of RIM, with temporally varying soil concentration profiles based on the variability in soil temperature and/or antecedent flow, were evaluated. The model where only the effects of riparian soil temperature on dynamics in DOC depth profiles were included performed best overall. This dynamic RIM improved the Nash‐Sutcliffe to 0.58 compared to 0.42 for the flow‐only formulation and reduced the median absolute error from 3.0 to 2.1 mg L−1. This study demonstrates that RIM is a simple way of modeling stream DOC and exploring controls on stream water chemistry.
Probing the Relation Between Charge Transport and Supramolecular Organization Down to Ångström Resolution in a Benzothiadiazole‐Cyclopentadithiophene Copolymer

Molecular modeling shows that longitudinal displacement of the backbones by a couple of ångströms has a profound impact on the electronic coupling mediating charge transport in a conjugated copolymer. These changes can be probed by monitoring the calculated X-ray scattering patterns and NMR chemical shifts as a function of sliding of the polymer chains and comparing them to experiment.
Novel Insight into Foam Mobility Control

laboratory study of foam propagation in natural sandstones in the absence of oil is reported. The goal of this study was to elucidate further the mechanisms of foam mobility control. The C14-16 Alpha-Olefin Sulfonate (AOS) surfactant was selected to stabilize nitrogen foam. X-ray CT scan images were taken during foam propagation to map liquid saturation over time. The effects of surfactant concentration and of total injection velocity were examined in detail as these are key parameters for controlling foam strength and foam propagation under field conditions.
Metabolic engineering to improve 1,5-diaminopentane production from cellobiose using β-glucosidase-secreting Corynebacterium glutamicum Running Title: Improved DAP production using C. glutamicum

権利 Rights © 2019 Wiley Periodicals, Inc. This is the peer reviewed version of the following art icle: [Matsuura, R, Kishida, M, Konishi, R, et al. Metabolic engineering to improve 1,5‐diaminopentane product ion from cellobiose using β‐glucosidase‐secret ing Corynebacterium glutamicum. Biotechnology and Bioengineering. 2019; 116: 26402651. ], which has been published in final form at ht tps://doi.org/10.1002/bit . 27082. This art icle may be used for non-commercial purposes in accordance with Wiley Terms and Condit ions for Use of Self-Archived Versions.
Glial and neuronal control of brain blood flow

Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation
Smoke Detection Based on RGB-Depth Camera in Interior

In this paper, an algorithm using RGB-depth camera is proposed to detect smoke in interrior. RGB-depth camera, the Kinect provides RGB color image and depth information. The Kinect sensor consists of an infra-red laser emitter, infra-red camera and an RGB camera. A specific pattern of speckles radiated from the laser source is projected onto the scene. This pattern is captured by the infra-red camera and is analyzed to get depth information. The distance of each speckle of the specific pattern is measured and the depth of object is estimated. As the depth of object is highly changed, the depth of object plain can not be determined by the Kinect. The depth of smoke can not be determined too because the density of smoke is changed with constant frequency and intensity of infra-red image is varied between each pixels. In this paper, a smoke detection algorithm using characteristics of the Kinect is proposed. The region that the depth information is not determined sets the candidate region of smoke. If the intensity of the candidate region of color image is larger than a threshold, the region is confirmed as smoke region. As results of simulations, it is shown that the proposed method is effective to detect smoke in interior.