Miracle-dz/UniFAR-FTUs huggingface dataset:
The February-March 2019 Seismic Swarm O ﬀ shore North Lefkada Island, Greece: Microseismicity Analysis and Geodynamic Implications

Featured Application: Authors are encouraged to provide a concise description of the speciﬁc application or a potential application of the work. This section is not mandatory. Abstract: A quite energetic seismic excitation consisting of one main and three additional distinctive earthquake clusters that occurred in the transition area between the Kefalonia Transform Fault Zone (KTFZ) and the continental collision between the Adriatic and Aegean microplates is thoroughly studied after the high-precision aftershocks’ relocation. The activated fault segments are in an area where historical and instrumental data have never claimed the occurrence of a catastrophic (M ≥ 6.0) earthquake. The relocated seismicity initially deﬁnes an activated structure extending from the northern segment of the Lefkada branch of KTFZ with the same NNE–SSW orientation and dextral strike slip faulting, and then keeping the same sense of motion, its strike becomes NE–SW and its dip direction NW. This provides unprecedented information on the link between the KTFZ and the collision front and sheds more light on the regional geodynamics. The earthquake catalog, which was especially compiled for this study, starts one year before the occurrence of the M w 5.4 main shock, and adequately provides the proper data source for investigating the temporal variation in the b value, which might be used for discriminating foreshock and aftershock behavior.
AN AUDIOVISUAL WORKSPACE FOR PHYSICAL MODELS

We present an experimental environment for working with physically based sound models. We situate physical models in an interactive multi-modal space. Users may interact with the models through touch, using tangible controllers, or by setting up procedurally animated physical machines. The system responds with both real-time sound and graphics. A built-in strongly-timed scripting language allows for a different kind of exploration. The scripting language may be used to play the models with precise timing, to change their relation, and to create new behaviors. This environment gives direct, concrete ways for users to learn about how physical models work and begin to explore new musical ideas.
Edinburgh Research Explorer The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C)

Mitotic progression is driven by proteolytic destruction of securin and cyclins. These proteins are labeled for destruction by an ubiquitin-protein isopeptide ligase (E3) known as the anaphase-promoting complex or cyclosome (APC/C). The APC/C requires activators (Cdc20 or Cdh1) to efficiently recog-nize its substrates, which are specified by destruction (D box) and/or KEN box signals. The spindle assembly checkpoint responds to unattached kinetochores and to kinetochores lacking tension, both of which reflect incomplete biorientation of chromosomes, by delaying the onset of anaphase. It does this by inhibiting Cdc20-APC/C. Certain checkpoint proteins interact directly with Cdc20, but it remains unclear how the checkpoint acts to efficiently inhibit Cdc20-APC/C activity. In the fission yeast, Schizosaccharomyces pombe , we find that the Mad3 and Mad2 spindle checkpoint proteins interact stably with the APC/C in mitosis. Mad3 contains two KEN boxes, conserved from yeast Mad3 to human BubR1, and mutation of either of these abrogates the spindle checkpoint. Strikingly, mutation of the N-terminal KEN box abolishes incorporation of Mad3 into the mitotic checkpoint complex (Mad3-Mad2-Slp1 in S. pombe, where Slp1 is the Cdc20 homolog that we will refer to as Cdc20 hereafter) and stable association of both Mad3 and Mad2 with the APC/C. Our findings demonstrate that this Mad3 KEN box is a critical mediator of Cdc20-APC/C inhibition, without which neither Mad3 nor Mad2 can associate with the APC/C or inhibit anaphase onset.
Epidermal Growth Factor Receptor Localization in the Rat and Monkey Testes1

Epidermal growth factor receptor (EGFR) was localized immunocytochemically in the testes of mature and immature rats and immature monkeys. One polyclonal antibody, recognizing the intracellular domain (RK2) of the receptor, was used to carry out the EGFR immunodetection. The RK2 antibody revealed the presence of the EGFR predominantly in Sertoli cells of mature and immature rats and of immature monkeys, although limited interstitial localization of the EGFR was also discerned in the mature rat. In cultured Sertoli cells of immature rats, grown in the absence of epidermal growth factor (EGF), the EGFR was randomly distributed at the cell surface, whereas after the addition of EGF the receptor became aggregated into distinct focal regions. In ad4i-zion, EGFR of cultured Sertoli cells exhibited autophosphorylation activity upon stimulation with EGF, but failed to transcytose iodinated EGF across a permeability barrier formed by the cultured cells. Instead, all of the added iodinated EGF was internalized and degraded.
On viscoelastic regularisation of strain-softening rocks and soils

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. On viscoelastic regularisation of strain-softening rocks and soils René de Borst, Thibault Duretz
Evolution of the equatorial oscillation in Saturn's stratosphere between 2005 and 2010 from Cassini/CIRS limb data analysis

We present an analysis of thermal infrared spectra acquired in limb viewing geometry by Cassini/CIRS in February 2010. We retrieve vertical profiles of Saturn's stratospheric temperature from 20 hPa to 10−2 hPa, at 9 latitudes between 20°N and 20°S. Using the gradient thermal wind equation, we derive a map of the zonal wind field. Both the temperature and the zonal wind vertical profiles exhibit an oscillation in the equatorial region. These results are compared to the temperature and zonal wind maps obtained from 2005–2006 CIRS limb data, when this oscillation was first reported. In both epochs, strong temperature anomalies at the equator (up to 20K) are consistent with adiabatic heating (cooling) due to a sinking (rising) motion at a speed of 0.1–0.2 mm/s. Finally, we show that the altitude of the maximum eastward wind has moved downwards by 1.3 scale heights in 4.2 years, hence with a ‘phase’ speed of ∼0.5 mm/s. This rate is consistent with the estimated period of 14.7 years for the equatorial oscillation, and requires a local zonal acceleration of 1.1 × 10−6 m.s−2 at the 2.5 hPa pressure level. This downward propagation of the oscillation is consistent with it being driven by absorption of upwardly propagating waves.
MAPK via p38 T Selectin Ligand Expression on Murine CD4 Diverse Inflammatory Cytokines Induce

Selectins are glycan-binding adhesion molecules that mediate the initial steps of leukocyte recognition of endothelium. Cytokines control numerous aspects of CD4 Th cell differentiation, but how cytokines control the induction of ligands for E- and P-selectin on Th cell subsets remains poorly understood. Among 20 cytokines that affect Th cell differentiation, we identiﬁed six that induce expression of selectin ligands on murine CD4 T cells above the low levels associated with TCR engagement: IL-12, IL-18, IL-27, IL-9, IL-25, and TGF- b 1. Collectively, these six cytokines could potentially account for selectin ligand expression on all of the currently deﬁned nonsessile Th cell lineages, including Th1, Th2, Th9, and Th17 cells, as well as regulatory T cells. Induction of selectin ligand expression by each of these six cytokines was almost completely inhibited by pharmacologic inhibition of p38 MAPK, but not other MAPKs, or by conditional genetic deletion of p38 a MAPK. Analysis of the expression of key glycosyl-transferase genes revealed that p38 a signaling was selectively required for induction of Fut7 and Gcnt1 but not for the induction of St3gal4 or St3gal6 . Constitutively active MKK6, an immediate upstream activator of p38 MAPK, induced selectin ligand expression equivalent to that of cytokines, and this induction was completely dependent on the expression of p38 a . Our results identify the repertoire of cytokines responsible for selectin ligand induction on CD4 T cells and provide a mechanistic link between Th cell development and T cell migration. The Journal of Immunology , 2015, 194: 000–000. TNF- a ); R&D Systems (TGF- b 1, TSLP, IFN- b ); Reprokine (IL-18, IL-25); or Axxora (IL-33). Expression of E- and P-selectin ligands on T cells was determined by staining with E- or P-selectin/IgM chimeras, followed by Alexa Fluor 647– anti-human IgM, as described (17, 19). We and other investigators showed previously that staining with these selectin chimeras closely and quanti-tatively tracks the ability of cells to roll on these selectins (15, 17, 18, 20, 22–24). Live/dead gating was with SYTOX Blue. Retrovirally transduced cells were identiﬁed by eGFP expression. Data were collected on a BD FACSCanto and analyzed using FlowJo software.
Some Lemmas on Reproducing Kernel Hilbert Spaces

Reproducing kernel Hilbert spaces (RKHS) provides a framework for approximation from finite data using the idea of bounded linear functionals. The approximation problem in this case can be viewed as the inverse problem of finding the optimum operator from the Euclidean space of observations to some subspace of the RKHS. In constructing the appropriate inverse operator use is made of both adjoint operators in RKHS and various norms. In this report a number of lemmas are given with respect to such adjoint operators and norms.
Supersymmetry - When Theory Inspires Experimental Searches

We review, in the first part of this work, many pioneering works on supersymmetry and organize these results to show how supersymmetric quantum field theories arise from spin-statistics, N{\oe}ther and a series of no-go theorems. We then introduce the so-called superspace formalism dedicated to the natural construction of supersymmetric Lagrangians and detail the most popular mechanisms leading to soft supersymmetry breaking. As an application, we describe the building of the Minimal Supersymmetric Standard Model and investigate current experimental limits on the parameter space of its most constrained versions. To this aim, we use various flavor, electroweak precision, cosmology and collider data. We then perform several phenomenological excursions beyond this minimal setup and probe effects due to non-minimal flavor violation in the squark sector, revisiting various constraints arising from indirect searches for superpartners. Next, we use several interfaced high-energy physics tools, including the FeynRules package and its UFO interface that we describe in detail, to study the phenomenology of two non- minimal supersymmetric models at the Large Hadron Collider. We estimate the sensitivity of this machine to monotop production in R-parity violating supersymmetry and sgluon-induced multitop production in R-symmetric supersymmetry. We then generalize the results to new physics scenarios designed from a bottom-up strategy and finally depict, from a theorist point of view, a search for monotops at the Tevatron motivated by these findings.
Back corona elimination by a new intermittent pulsed power supply for electrostatic precipitators s

 Abstract — A cost effective power supply design proposed for electrostatic precipitators is presented in this article. The cost minimization is done in terms of eliminating the power transformer and reducing power consumed by ESP unit. Usually, transformers are used to boost the voltage level in conventional systems on its input side, which is proposed to be replaced by a combination of a high frequency converter along with a voltage multiplier as modular arrangement. By interconnecting these modules, the desired voltage is built up easily. An intermittent pulse energised supply is developed by the proposed system to avoid back corona and to save energy consumption. This modular arrangement also increases the lifetime of converter switches by reducing the switching stresses developed across it during its high frequency operation and the THD generated is also analysed using FFT analysis. The complete system is designed and analysed using MATLAB SIMULINK.
3D Measures Computed in Monocular Camera System for Fall Detection

—Traumas resulting from falls have been reported as the second most common cause of death. For this reason, computer vision tools can be exploited for detecting humans’ fall incidents. In this paper, we propose a fast, real-time computer vision algorithm capable to detect humans’ falls in complex dynamically changing conditions, by exploiting the motion information in the scene and 3D space’s measures. This algorithm is using a single monocular low cost camera and it requires minimal computational cost and minimal memory requirements that make it suitable for large scale implementations in clinical institutes and home environments. The proposed scheme was tested in complex and dynamically changing visual conditions and as proved by the experiments it has the capability to detect over 92% of fall incidents.
Predictability, Stability, and Computability of Locally Learnt SVMs

Abstract We will have a look at the principles predictability, stability, and computability in the field of support vector machines. Support vector machines (SVMs), well-known in machine learning, play a successful role in classification and regression in many areas of science. In the past three decades, much research has been conducted on the statistical and computational properties of support vector machines and related kernel methods. On the one hand, consistency (predictability) and robustness (stability) of the method are of interest. On the other hand, from an applied point of view, there is interest in a method that can deal with many observations and many features (computability). Since SVMs require a lot of computing power and storage capacity, various possibilities for processing large data sets have been proposed. One of them is called regionalization. It divides the space of declaring variables into possibly overlapping domains in a data driven way and defines the function to predict the output by the formation of locally learnt support vector machines. Another advantage of regionalization should be mentioned.
Positional dependence of FDTD mode detection in photonic crystal systems

We have developed an algorithm for evaluating the accuracy and reliability of photonic crystal (PhC) simulations, and used it to analyze the influence of excitation and detector placement in finite‐difference time‐domain algorithm (FDTD) simulations of two canonical PhC systems. In order to perform this computationally expensive analysis, we evaluated the use of filter diagonalization as an alternative to the Fourier Transform for mode detection, and developed a parallelization algorithm to take advantage of the inherent concurrency in simulating periodic systems. A map of locations where mode detection fails was generated, and we show that this is equivalent to a map of the node densities of the system. In addition to the expected high nodal densities at the symmetry areas of each system, we find more difficult to characterize patterns of high nodal density for the higher‐order modes. Based on the observed behavior we are able to provide concrete rules to optimize the detection and excitation of modes in FDTD simulations of PhC systems. Although PhCs were studied, the presented strategies and results apply to the much broader class of all computational time‐domain problems where Bloch–Floquet boundary conditions are used. Copyright © 2008 John Wiley & Sons, Ltd.
Determinants of environmental assessment of Polish individual wastewater treatment plants in a life cycle perspective

: The article presents results of an input-output data inventory and life cycle assessment (LCA) for individual wastewater treatment plants (IWWTPs), considering their whole life cycle, including the stage of construction, use and end-of-life. IWWTPs located in the area of a medium-sized town in Poland, were assessed from a systemic perspective. The research was conducted basing on actual data concerning performance of 304 individual wastewater treatment plants in Ż ory. Environmental assessment was conducted with ReCiPe and TRACI methods. Greenhouse gases (GHG) emission, eutrophication, fossil fuel and metal depletion were calculated. The LCA was conducted basing on ISO 14040 standard with SimaPro 8 software and Ecoinvent 3 database. The system boundary ranged from cradle to grave. It was shown that, at the construction stage, GHG emission depends on the amount of used cement, polyethylene, concrete, PVC and polypropylene. At the use stage, the GHG emission is determined by the sewage treatment technology and application of a bio-reactor in IWWTPs. At the construction stage, the fossil fuel depletion is determined by the amount of used polyethylene, PVC, cement, polypropylene and concrete; while the metal depletion is determined by the amount of used stainless steel, copper and cast iron. Data inventory and LCA of IWWTPs are presented for the ﬁ rst time. Conclusions of the work may support decisions taken by local governments concerning wastewater management in their area and promote and support solutions of high ecological standards.
In Situ Characterization of Nitrospira -Like Nitrite-Oxidizing Bacteria Active in Wastewater Treatment Plants

Uncultivated Nitrospira -like bacteria in different bioﬁlm and activated-sludge samples were investigated by cultivation-independent molecular approaches. Initially, the phylogenetic afﬁliation of Nitrospira -like bacteria in a nitrifying bioﬁlm was determined by 16S rRNA gene sequence analysis. Subsequently, a phylogenetic consensus tree of the Nitrospira phylum including all publicly available sequences was constructed. This analysis revealed that the genus Nitrospira consists of at least four distinct sublineages. Based on these data, two 16S rRNA-directed oligonucleotide probes speciﬁc for the phylum and genus Nitrospira , respectively, were developed and evaluated for suitability for ﬂuorescence in situ hybridization (FISH). The probes were used to investigate the in situ architecture of cell aggregates of Nitrospira -like nitrite oxidizers in wastewater treatment plants by FISH, confocal laser scanning microscopy, and computer-aided three-dimensional visualization. Cavities and a network of cell-free channels inside the Nitrospira microcolonies were detected that were water permeable, as demonstrated by ﬂuorescein staining. The uptake of different carbon sources by Nitrospira -like bacteria within their natural habitat under different incubation conditions was studied by combined FISH and microautoradiography. Under aerobic conditions, the Nitrospira -like bacteria in bioreactor samples took up inorganic carbon (as HCO 3 (cid:1) or as CO 2 ) and pyruvate but not acetate, butyrate, and propionate, suggesting that these bacteria can grow mixotrophically in the presence of pyruvate. In contrast, no uptake by the Nitrospira -like bacteria of any of the carbon sources tested was observed under anoxic or anaerobic conditions. (37). a volume-rendering algorithm published elsewhere (13) that draws surfaces automatically and independently of user-supplied intensity levels. The results of the two visualization techniques were evaluated by generating isosurfaces with different intensity levels and by comparing these isosurfaces visually with the surfaces drawn by the volume-rendering algorithm. During this evaluation, the most suitable intensity levels were selected for drawing of the cell clusters as isosurfaces in the ﬁnal images. All voids within cell clusters were drawn colored and semitransparent to visualize the cavities and channels in the cell aggregates.
CASE STUDY AND REPORT

: The introduction of cloud computing has triggered a change in computer community. The varying requirements of users are faultlessly met by the cloud. The cloud is used for a variety of purposes including storage services. Cloud storage services allow users to store their data and thus reduce space consumption. But security and privacy of data stored in cloud is a major issue faced by the user’s and service providers alike. This paper deals with the threats faced by the storage service providers and users in the area of data storage in cloud. The paper then proceeds to outline the need for auditing protocols and the challenges faced by them when it comes to the context of cloud. The paper concludes with an introduction into some of the cloud auditing protocols
DEV122184 1..6

Genes related to Dmrt1, which encodes a DNA-binding DM domain transcription factor, act as triggers for primary sex determination in a broad range of metazoan species. However, this role is fulfilled in mammalsbySry, anewlyevolvedgeneon theYchromosome, such that Dmrt1 has become dispensable for primary sex determination and instead maintains Sertoli cell phenotype in postnatal testes. Here, we report that enforced expression of Dmrt1 in XX mouse fetal gonads using a Wt1-BAC transgene system is sufficient to drive testicular differentiation and male secondary sex development. XX transgenic fetal gonads showed typical testicular size and vasculature. Keyovarian markers, including Wnt4 and Foxl2, were repressed. Sertoli cells expressing the hallmark testis-determining gene Sox9 were formed, although they did not assemble into normal testis cords. Other bipotential lineages differentiated into testicular cell types, including steroidogenic fetal Leydig cells and non-meiotic germ cells. As a consequence, male internal and external reproductive organs developed postnatally, with an absence of female reproductive tissues. These results reveal that Dmrt1 has retained its ability to act as the primary testis-determining trigger in mammals, even though this function isno longernormally required. Thus,Dmrt1providesacommon thread in the evolution of sex determinationmechanisms inmetazoans.
-Transformed T Cells Herpesvirus saimiri Signaling Molecules in IL-2-Independent Cutting Edge: Constitutive Activation of TCR

Both human T cell leukemia virus type I and simian Herpesvirus saimiri (HVS) transform human T cells in vitro. Although IL-2-independent growth in human T cell leukemia virus type I-transformed T cells is associated with constitutive phosphorylation of JAK/STAT kinases, we now demonstrate that different mechanisms may be responsible for the ability of HVS-transformed T cells to proliferate in the absence of exogenous cytokines. The IL-2 independence of an HVS-transformed cell line correlated with constitutive activation of protein tyrosine kinases known to be induced following TCR engagement. Thus, in these cells we observed increased phosphotransferase activity of Lck as well as constitutive tyrosine phosphorylation of the TCR-associated ZAP-70 kinase and expression of the related Syk protein tyrosine kinase. While Syk is generally not expressed in activated T cells, its introduction has been shown to enhance TCR responsiveness. These results suggest that distinct signal transduction cascades can participate in the transition of T cells to IL-2 independence. The Journal of Immunology, 1998, 160: 2042–2045. resolved on SDS-PAGE and visualized by autoradiography. Quantitative analysis was performed on a PhosphorImager (model 445SI, Molecular Dynamics, Sunnyvale, CA).