Miracle-dz/UniFAR-FTUs huggingface dataset:
Can International Capital Standards Strengthen Banks in Emerging Markets?

Who should determine banks' capital standards: authorities or markets? What is the right definition of core capital: equity only or equity plus subordinated debt? Can the assessment of banks' individual credit risks by external rating agencies be of equal or better quality than the assessments derived from banks' own internal rating systems? These are some of the key financial regulatory issues currently being discussed by analysts in industrial countries, especially in the context of the proposed modification to the Basel Capital Adequacy Accord: Basel II is expected to replace the original 1988 Accord. With a few exceptions, these issues are certainly not at the center of the debate in emerging market financial circles. There, the financial issues at hand depend on the country's level of development. For the least developed countries, reform agendas are just advancing in the implementation of accounting standards, disclosure, and other principles of bank supervision; Basel II is certainly not in the medium-term future. If anything, implementation of the original Accord is the issue. The more advanced emerging economies face a different dilemma. Albeit at very different paces, most of these countries embarked on a financial sector reform process in the early 1990s. One of the most important efforts by individual countries, also strongly supported by multilateral organizations, has been the adoption of the recommendations on capital adequacy requirements by the Basel Committee on Banking Supervision. However, in spite of significant advances in implementation, banking crises have abounded in emerging markets during the 1990s and early 2000s. Not surprisingly, some disillusion with a "traditional" reform agenda has emerged. A key debate, therefore, centers on assessing whether regulatory standards that work in industrial countries are appropriate for emerging markets. Among the most relevant issues are: (a) Can an early warning system of banking crisis particular to emerging markets be constructed? (b) How should capital adequacy ratios be designed in emerging markets? Should they diverge from the recommendations of Basel? And, (c) rather than focusing on "strengthening" banks, shouldn't emerging markets limit the role of banks, and instead, focus on the development of corporate bond markets? This paper deals with the appropriateness for emerging markets of implementing capital requirements as recommended by the Basel Committee on Banking Supervision. The paper is part of a research agenda that I initiated in the late-1990s. In my previous research I concluded that such capital standards have had very little usefulness as a supervisory tool in emerging markets. For fundamental reasons that go beyond the improvements in regulatory procedures, and, instead center on the particular features of financial sectors in many emerging economies, the capital-to-asset ratio has not been a useful early warning indicator of banking problems.
MicroRNAs as regulators in plant metal toxicity response

Metal toxicity is a major stress affecting crop production. This includes metals that are essential for plants (copper, iron, zinc, manganese), and non-essential metals (cadmium, aluminum, cobalt, mercury). A primary common effect of high concentrations of metal such as aluminum, copper, cadmium, or mercury is root growth inhibition. Metal toxicity triggers the accumulation of reactive oxygen species leading to damage of lipids, proteins, and DNA. The plants response to metal toxicity involves several biological processes that require fine and precise regulation at transcriptional and post-transcriptional levels. MicroRNAs (miRNAs) are 21 nucleotide non-coding RNAs that regulate gene expression at the post-transcriptional level. A miRNA, incorporated into a RNA-induced silencing complex, promotes cleavage of its target mRNA that is recognized by an almost perfect base complementarity. In plants, miRNA regulation is involved in development and also in biotic and abiotic stress responses. We review novel advances in identifying miRNAs related to metal toxicity responses and their potential role according to their targets. Most of the targets for plant metal-responsive miRNAs are transcription factors. Information about metal-responsive miRNAs in different plants points to important regulatory roles of miR319, miR390, miR393, and miR398. The target of miR319 is the TCP transcription factor, implicated in growth control. miR390 exerts its action through the biogenesis of trans-acting small interference RNAs that, in turn, regulate auxin responsive factors. miR393 targets the auxin receptors TIR1/AFBs and a bHLH transcription factor. Increasing evidence points to the crucial role of miR398 and its targets Cu/Zn superoxide dismutases in the control of the oxidative stress generated after high copper or iron exposure.
Herpesviral infections and antimicrobial protection for Alzheimer's disease: Implications for prevention and treatment

Accumulating evidence suggests that infections by herpesviruses might be closely linked to Alzheimer's disease (AD). Pathological hallmarks of AD brains include senile plaques induced by amyloid β peptide (Aβ) in the extracellular space and intracellular neurofibrillary tangles (NFTs) consisting of phosphorylated tau protein. The prevailing hypothesis for the mechanism of AD is amyloid cascade reaction. Recent studies revealed that infections by herpesviruses induce the similar pathological hallmarks of AD, including Aβ production, phosphorylation of tau (P‐tau), oxidative stress, neuroinflammation, etc. Aβ peptide is regarded as one of the antimicrobial peptides, which inhibits HSV‐1 replication. In the elderly, reactivation of herpesviruses might act as an initiator for amyloid cascade reaction in vulnerable individuals, triggering the neurofibrillary formation of phosphorylated tau and inducing oxidative stress and neuroinflammation, which can further contribute to the accumulation of Aβ and P‐tau by impairing mitochondria and autophagosome. Epidemiological studies have shown AD susceptibility genes, such as APOE‐ε4 allele, are highly linked to infections by herpesviruses. Interestingly, anti‐herpesviral therapy significantly reduced the risk of AD in a large population study. Given that herpesviruses are arguably the most prevalent opportunistic pathogens and often reactivate in the elderly, it is reasonable to argue reactivation of herpesviruses might be major culprits for initiating AD in individuals carrying AD susceptibility genes. In this review, we summarize epidemiological and molecular evidence that support for a hypothesis of herpesviral infections and antimicrobial protection in the development of AD, and discuss the implications for future prevention and treatment of the disease.
Weathering Risk in Rural Mexico: Climatic, Institutional, and Economic Change

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Effect of Elastic Modulus and Poisson's Ratio on Guided Wave Dispersion Using Transversely Isotropic Material Modelling

Timber poles are commonly used for telecommunication and power distribution networks, wharves or jetties, piling or as a substructure of short span bridges. Most of the available techniques currently used for non-destructive testing (NDT) of timber structures are based on one-dimensional wave theory. If it is essential to detect small sized damage, it becomes necessary to consider guided wave (GW) propagation as the behaviour of different propagating modes cannot be represented by one-dimensional approximations. However, due to the orthotropic material properties of timber, the modelling of guided waves can be complex. No analytical solution can be found for plotting dispersion curves for orthotropic thick cylindrical waveguides even though very few literatures can be found on the theory of GW for anisotropic cylindrical waveguide. In addition, purely numerical approaches are available for solving these curves. In this paper, dispersion curves for orthotropic cylinders are computed using the scaled boundary finite element method (SBFEM) and compared with an isotropic material model to indicate the importance of considering timber as an anisotropic material. Moreover, some simplification is made on orthotropic behaviour of timber to make it transversely isotropic due to the fact that, analytical approaches for transversely isotropic cylinder are widely available in the literature. Also, the applicability of considering timber as a transversely isotropic material is discussed. As an orthotropic material, most material testing results of timber found in the literature include 9 elastic constants (three elastic moduli and six Poisson's ratios), hence it is essential to select the appropriate material properties for transversely isotropic material which includes only 5 elastic constants. Therefore, comparison between orthotropic and transversely isotropic material model is also presented in this article to reveal the effect of elastic moduli and Poisson's ratios on dispersion curves. Based on this study, some suggestions are proposed on selecting the parameters from an orthotropic model to transversely isotropic condition.
cif-Diamminedichloroplatinum ( II )-resistant Sublines Derived from Two Human Ovarian Tumor Cell Lines 1

In two human ovarian tumor cell lines, resistance to ciVdiamminedichloroplatinum(II) (CDDP) was induced by continuous exposure of the parental lines to an increasing CDDP concentration in the culture medium. In contrast, a six times repeated pulse exposure of 6.7 jtM or 16.7 MMCDDP for l h did not result in a cell line that showed a higher survival in CDDP-containing medium. The IDW value for CDDP was seven to eight times higher for the resistant lines and those lines were able to grow at 3.3 JIMCDDP. The induced resistance was stable during at least 25 doubling times. The CDDP-resistant sublines showed cross-resistance to the CDDP-analogues crWiammine-l,l-cyclobutanedicarboxylateplatinum(II) and m-dichlorobis(isopropylamine)-rranÂ£dihydroxyplatinum(IV) indicating that resistance to the different plati num compounds is generated by a common mechanism. The resistant sublines were also cross-resistant to mitomycin C and melphalan. The degree of cross-resistance for the tested drugs varied widely between the two cell lines. Resistance to CDDP was clearly correlated to decreased amounts of platinum in the resistant cells as compared to the sensitive cells. The amplification and expression of genes encoding proteins that had been shown to be involved in multidrug resistance, e.g., the M, 170,000 P-glycoprotein was also studied. No amplification or overexpression of these genes could be shown in the resistant cell lines.
Can we believe what children tell us?

It’s a great honour to be able to give the Howard Williams Oration. When I looked at the distinguished list of previous orators, it made me approach the task with some trepidation. But I also approached it with delight because Howard Williams had been a great encouragement to me in my early years and this is an opportunity to acknowledge his contribution to Australian paediatrics I want to start with what I have learned about child abuse, particularly the long-term consequences, how recent research is starting to provide an explanation for some of the things we have observed in the past and then move to the topic of this presentation, ‘Can we believe what children tell us? ’
Parental vaccine knowledge and behaviours: a survey of Turkish families.

Background Personal and herd immunity require durability in high vaccination coverage rates, and this mainly depends on the interaction between parental and service/provider factors. Aims The aim of this study was to assess Turkish parents' knowledge and behaviours concerning childhood vaccination and their association with familial sociodemographic characteristics. Methods A cross-sectional survey, including a questionnaire, was conducted with parents of children aged between 1 day and 120 months. Results Of the 903 index children, 881 (97.6%) were up to date for all vaccinations by age. Demographic variables were not related to belief in protection through vaccination or rejection of obligatory vaccines. Mean age, education level, occupation of mother (P = 0.006, P < 0.001, and P = 0.01, respectively) and father (P = 0.002, P < 0.001, and P = 0.006, respectively), average monthly household income (P < 0.001), and experience of vaccine side-effects (P = 0.02) were associated with knowledge about optional childhood vaccines. Father's education level was independently associated with knowledge about optional childhood vaccines. Conclusions Having any experience of vaccine side-effects and parental sociodemographic characteristics, especially father's education level, affect Turkish parents' knowledge of childhood optional vaccines.
Defect-induced band restructuring and length scales in twisted bilayer graphene

We investigate the effects of single, multiple, and extended defects in the form of non-magnetic impurities and vacancies in twisted bilayer graphene (TBG) at and away from the magic angle, using a fully atomistic model and focusing on the behavior of the flat low-energy moir\'e bands. For strong impurities and vacancies in the $AA$ region we find a complete removal of one of the four moir\'e bands, resulting in a significant depletion of the charge density in the $AA$ regions even at extremely low defect concentrations. We find similar results for other defect locations, with the exception of the least coordinated sites in the $AB$ region, where defects instead result in a peculiar band replacement process within the moir\'e bands. In the vacancy limit, this process yields a band structure misleadingly similar to the pristine case. Moreover, we show that triple point fermions (TPFs), which are the crossing of the Dirac point by a flat band, appearing for single, periodic, defects, are generally not preserved when adding extended or multiple defects, and thus likely not experimentally relevant. We further identify two universal length scales for defects, consisting of charge modulations on the atomic scale and on the moir\'e scale, illustrating the importance of both the atomic and moir\'e structures for understanding TBG. We show that our conclusions hold beyond the magic angle and for fully isolated defects. In summary, our results demonstrate that the normal state of TBG and its moir\'e flat bands are extremely sensitive to both the location and strength of non-magnetic impurities and vacancies, which should have significant implications for any emergent ordered state.
Effects of Framing Proximal Benefits of Quitting and Motivation to Quit as a Query on Communications About Tobacco Constituents

Introduction Little is known on how to communicate messages on tobacco constituents to tobacco users. This study manipulated three elements of a message in the context of a theory-based communication campaign about tobacco constituents: (1) latency of response efficacy (how soon expected health benefits would accrue), (2) self-efficacy (confidence about quitting), and (3) interrogative cue ("Ready to be tobacco-free? "). Methods Smokers (N = 1669, 55.4% women) were recruited via an online platform, and were randomized to a 3 (Latency of response efficacy) × 2 (Self-efficacy) × 2 (Interrogative cue) factorial design. The dependent variables were believability, credibility, perceived effectiveness of the communication message, and action expectancies (likelihood of seeking additional information and help with quitting). Results Latency of response efficacy influenced believability, perceived effectiveness, credibility, and action expectancies. In each case, scores were higher when specific health benefits were said to accrue within 1 month, as compared to general health benefits occurring in a few hours. The interrogative cue had a marginal positive effect on perceived effectiveness. The self-efficacy manipulation had no reliable effects, and there were no significant interactions among conditions. Conclusions Smokers appear less persuaded by a communication message on constituents where general health benefits accrue immediately (within a few hours) than specific benefits over a longer timeframe (1 month). Additionally, smokers appeared to be more persuaded by messages with an interrogative cue. Such findings may help design more effective communication campaigns on tobacco constituents to smokers. Implications This paper describes, for the first time, how components of tobacco constituent messages are perceived. We now know that smokers appear to be less persuaded by communication messages where general health benefits accrue immediately (within a few hours) than specific benefits over a longer timeframe (1 month). Additionally, including an interrogative cue ("Ready to be tobacco free? ") may make messages more effective, whereas the self-efficacy manipulation designed to increase confidence about quitting had no effect. While messages were universally impactful across smoker subpopulations, everyday smokers and smokers with less trust in the government may be less receptive to communication campaigns.
Current Concepts in the Rehabilitation of the Overhead Throwing Athlete

The overhead throwing motion is an extremely skillful and intricate movement that is very stressful on the shoulder joint complex. The overhead throwing athlete places extraordinary demands on this complex. Excessively high stresses are applied to the shoulder joint because of the tremendous forces generated by the thrower. The thrower's shoulder must be lax enough to allow excessive external rotation, but stable enough to prevent symptomatic humeral head subluxations, thus requiring a delicate balance between mobility and functional stability. We refer to this as the “thrower's paradox. ” This balance is frequently compromised, which leads to injury. Numerous types of injuries may occur to the surrounding tissues during overhead throwing. Frequently, injuries can be successfully treated with a well-structured and carefully implemented nonoperative rehabilitation program. The key to successful nonoperative treatment is a thorough clinical examination and accurate diagnosis. Athletes often exhibit numerous adaptive changes that develop from the repetitive microtraumatic stresses observed during overhead throwing. Treatment should focus on the restoration of these adaptations during the rehabilitation program. In this article, the typical musculoskeletal profile of the overhead thrower and various rehabilitation programs for specific injuries are discussed. Rehabilitation follows a structured, multiphase approach with emphasis on controlling inflammation, restoring muscle balance, improving soft tissue flexibility, enhancing proprioception and neuromuscular control, and efficiently returning the athlete to competitive throwing.
Some open questions in ‘wave chaos’

The subject area referred to as ‘wave chaos’, ‘quantum chaos’ or ‘quantum chaology’ has been investigated mostly by the theoretical physics community in the last 30 years. The questions it raises have more recently also attracted the attention of mathematicians and mathematical physicists, due to connections with number theory, graph theory, Riemannian, hyperbolic or complex geometry, classical dynamical systems, probability, etc. After giving a rough account on ‘what is quantum chaos? ’, I intend to list some pending questions, some of them having been raised a long time ago, some others more recent. The choice of problems (and of references) is of course partial and personal.
PERSPECTIVE: THE ORIGIN OF FLOWERING PLANTS AND THEIR REPRODUCTIVE BIOLOGY–A TALE OF TWO PHYLOGENIES

Recently, two areas of plant phylogeny have developed in ways that could not have been anticipated, even a few years ago. Among extant seed plants, new phylogenetic hypotheses suggest that Gnetales, a group of nonflowering seed plants widely hypothesized to be the closest extant relatives of angiosperms, may be less closely related to angiosperms than was believed. In addition, recent phylogenetic analyses of angiosperms have, for the first time, clearly identified the earliest lineages of flowering plants: Amborella, Nymphaeales, and a clade that includes Illiciales/Trimeniaceae/Austrobaileyaceae. Together, the new seed plant and angiosperm phylogenetic hypotheses have major implications for interpretation of homology and character evolution associated with the origin and early history of flowering plants. As an example of the complex and often unpredictable interplay of phylogenetic and comparative biology, we analyze the evolution of double fertilization, a process that forms a diploid embryo and a triploid endosperm, the embryo‐nourishing tissue unique to flowering plants. We demonstrate how the new phylogenetic hypotheses for seed plants and angiosperms can significantly alter previous interpretations of evolutionary homology and firmly entrenched assumptions about what is synapomorphic of flowering plants. In the case of endosperm, a solution to the century‐old question of its potential homology with an embryo or a female gametophyte (the haploid egg‐producing generation within the life cycle of a seed plant) remains complex and elusive. Too little is known of the comparative reproductive biology of extant nonflowering seed plants (Gnetales, conifers, cycads, and Ginkgo) to analyze definitively the potential homology of endosperm with antecedent structures. Remarkably, the new angiosperm phylogenies reveal that a second fertilization event to yield a biparental endosperm, long assumed to be an important synapomorphy of flowering plants, cannot be conclusively resolved as ancestral for flowering plants. Although substantive progress has been made in the analysis of phylogenetic relationships of seed plants and angiosperms, these efforts have not been matched by comparable levels of activity in comparative biology. The consequence of inadequate comparative biological information in an age of phylogenetic biology is a severe limitation on the potential to reconstruct key evolutionary historical events.