Miracle-dz/UniFAR-FTUs huggingface dataset:
Small RNA F6 Provides Mycobacterium smegmatis Entry into Dormancy

Regulatory small non-coding RNAs play a significant role in bacterial adaptation to changing environmental conditions. Various stresses such as hypoxia and nutrient starvation cause a reduction in the metabolic activity of Mycobacterium smegmatis, leading to entry into dormancy. We investigated the functional role of F6, a small RNA of M. smegmatis, and constructed an F6 deletion strain of M. smegmatis. Using the RNA-seq approach, we demonstrated that gene expression changes that accompany F6 deletion contributed to bacterial resistance against oxidative stress. We also found that F6 directly interacted with 5′-UTR of MSMEG_4640 mRNA encoding RpfE2, a resuscitation-promoting factor, which led to the downregulation of RpfE2 expression. The F6 deletion strain was characterized by the reduced ability to enter into dormancy (non-culturability) in the potassium deficiency model compared to the wild-type strain, indicating that F6 significantly contributes to bacterial adaptation to non-optimal growth conditions.
A large-scale dataset for indoor visual localization with high-precision ground truth

This article presents a challenging new dataset for indoor localization research. We have recorded the whole internal structure of Fengtai Wanda Plaza which is an area of over 15,800 m2 with a Navvis M6 device. The dataset contains 679 RGB-D panoramas and 2,664 query images collected by three different smartphones. In addition to the data, an aligned 3D point cloud is produced after the elimination of moving objects based on the building floorplan. Furthermore, a method is provided to generate corresponding high-resolution depth images for each panorama. By fixing the smartphones on the device using a specially designed bracket, six-degree-of-freedom camera poses can be calculated precisely. We believe it can give a new benchmark for indoor visual localization and the full dataset can be downloaded from http://vision.ia. ac.cn/Faculty/wgao/data_code/data_indoor_localizaiton/data_indoor_localization. htm
Raising aspirations

Somerset Community Foundation launched Raising Aspirations in 2011 to improve the educational and employment aspirations of young people in Somerset. An independent evaluation of the programme at Crispin School in Street shows that, after 12 months young people had improved levels of self-esteem; increased selfbelief, and an increased perception of the support that is available to them from family and significant others. After 24 months of mentoring, these outcomes translated into higher aspirations to achieve academically, compared to their peers.
Political participation and small-scale fishery management in the Tonlé Sap, Cambodia

ABSTRACT This paper investigates fishery governance in Tonlé Sap, Cambodia, with a specific focus on fishery management since 1963 and recent determinants of political participation. The research suggests that the policy reforms leading to the implementation of open-access fisheries have not produced satisfactory outcomes due to inequitable access to fishery resources. The results of statistical analyses reveal: the dependency of small-scale fisherfolk on fishery resources; the level of institutional support available to small-scale fisherfolk; the capacity of the local community; and the important roles fishery management initiatives play in determining the level of political participation in fishery governance.
Transcriptome Analysis of Testicular Aging in Mice

Male reproductive aging, or andropause, is associated with gradual age-related changes in testicular properties, sperm production, and erectile function. The testis, which is the primary male reproductive organ, produces sperm and androgens. To understand the transcriptional changes underlying male reproductive aging, we performed transcriptome analysis of aging testes in mice. A total of 31,386 mRNAs and 9387 long non-coding RNAs (lncRNAs) were identified in the mouse testes of diverse age groups (3, 6, 12, and 18 months old) by total RNA sequencing. Of them, 1571 mRNAs and 715 lncRNAs exhibited changes in their levels during testicular aging. Most of these aging-related transcripts exhibited slight and continuous expression changes during aging, whereas some (9.6%) showed larger expression changes. The aging-related transcripts could be classified into diverse expression patterns, in which the transcripts changed mainly at 3–6 months or at 12–18 months. Our subsequent in silico analysis provided insight into the potential features of testicular aging-related mRNAs and lncRNAs. We identified testis-specific aging-related transcripts (121 mRNAs and 25 lncRNAs) by comparison with a known testis-specific transcript profile, and then predicted the potential reproduction-related functions of the mRNAs. By selecting transcripts that are altered only between 3 and 18 months, we identified 46 mRNAs and 34 lncRNAs that are stringently related to the terminal stage of male reproductive aging. Some of these mRNAs were related to hormonal regulation. Finally, our in silico analysis of the 34 aging-related lncRNAs revealed that they co-localized with 19 testis-expressed protein-coding genes, 13 of which are considered to show testis-specific or -predominant expression. These nearby genes could be potential targets of cis-regulation by the aging-related lncRNAs. Collectively, our results identify a number of testicular aging-related mRNAs and lncRNAs in mice and provide a basis for the future investigation of these transcripts in the context of aging-associated testicular dysfunction.
Characterization of the first complete chloroplast genome of Amaranthus hybridus (Caryophyllales: Amaranthaceae) with phylogenetic implications

Abstract In the present study, the complete chloroplast genome of Amaranthus hybridus was sequenced and assembled. The complete chloroplast genome of Amaranthus hybridus is 150,709 in size, with the GC content of 36.56%. The chloroplast genome of Amaranthus hybridus contained 86 protein-coding genes (PCGs), eight ribosomal RNA (rRNA) genes, and 37 transfer RNA (tRNA) genes. Phylogenetic analysis based on combined chloroplast gene dataset indicated that the Amaranthus hybridus exhibited a close relationship with A. hypochondriacus and A. caudatus.
An Introduction

When a child, of whatever age, loses a loved one, childhood comes abruptly to an end. This is the message of the first lines of Edna St. Vincent Millay’s poem, “Childhood Is the KingdomWhere Nobody Dies” (1943). The ensuing stanzas reveal that children may experience the death of a distant relative or pet without suffering traumatic loss, but the death of someone who matters deeply to the child will be shattering. The poem’s title, repeated as a refrain, conveys anothermore obliquemessage as well, namely that there is no place for death in the innocent world of childhood. In his classic essay,Western Attitudes Toward Death: From theMiddle Ages to the Present (1974), written 30 years after Millay’s poem, Phillip Ariès saw this sentiment as part of the “modern interdiction of death. ” He remarked, “Think of how carefully people today keep children away from anything to do
esearch lectures s osteoarthritis a metabolic disease ?

Obesity, together with aging and injury, is among the main risk factors for osteoarthritis. Obesity-related osteoarthritis can affect not only the weight-bearing joints, but also the hands, suggesting a role for circulating mediators released by the adipose tissue and known as adipokines. Thus, osteoarthritis may have a systemic metabolic component. Evidence from both epidemiological and biological studies support the concept of metabolic osteoarthritis, defined as a broad clinical phenotype that includes obesityrelated osteoarthritis. Thus, osteoarthritis can be related to metabolic syndrome or to an accumulation of metabolic abnormalities. In addition, studies have demonstrated associations linking osteoarthritis to
The Hall Effect

The Hall effect in a thin bismuth strip was investigated. The Hall voltage was found to be a linear function of the applied current, in agreement with theoretical predictions. However, the Hall voltage was a highly nonlinear function of the magnetic field, in contrast to the linear form predicted by the semiclassical theory. At high magnetic fields, where electron scattering is less important and the simple theory is expected to hold, we find an electron density of around 1–2×1019 cm−3.
Contrasting Patterns of Sensory Adaptation in Living and Extinct Flightless Birds

Avian cranial anatomy is constrained by the competing (or complementary) requirements and costs of various facial, muscular, sensory, and central neural structures. However, these constraints may operate differently in flighted versus flightless birds. We investigated cranial sense organ morphology in four lineages of flightless birds: kiwi (Apteryx), the Kakapo (Strigops habroptilus), and the extinct moa (Dinornithiformes) from New Zealand; and the extinct elephant birds from Madagascar (Aepyornithidae). Scleral ring and eye measurements suggest that the Upland Moa (Megalapteryx didinus) was diurnal, while measurements for the Kakapo are consistent with nocturnality. Kiwi are olfactory specialists, though here we postulate that retronasal olfaction is the dominant olfactory route in this lineage. We suggest that the Upland Moa and aepyornithids were also olfactory specialists; the former additionally displaying prominent bill tip sensory organs implicated in mechanoreception. Finally, the relative size of the endosseous cochlear duct revealed that the Upland Moa had a well-developed hearing sensitivity range, while the sensitivity of the kiwi, Kakapo, and aepyornithids was diminished. Together, our results reveal contrasting sensory strategies among extant and extinct flightless birds. More detailed characterisation of sensory capacities and cranial anatomy in extant birds may refine our ability to make accurate inferences about the sensory capacities of fossil taxa.
Prospects for the use of a drug based on a complex of fatty acid esters in models of laboratory animals in vivo

In this work we carried out studies of the first obtained micellar composition of fatty acid esters with allantoin on a water basis to determine its local irritant effect and therapeutic efficacy in the treatment of burns. It was found that there was a sequential change in the phases of the burn wound process in all groups. During the observation period, wound suppuration was not observed; there were 4 cases of a complicated course of the wound process and a fatal outcome in the control group. When conducting studies of local irritant effects, the assessment was carried out in points, in the experimental group it was on average 2 points as for the animals of the control group. The conducted studies allow us to conclude that the drug, when applied to the skin according to the interstate standard GOST ISO 10993-10—2011, has a weak degree of response to irritation in guinea pigs. The application of a permissive dose of the drug to sensitized guinea pigs does not cause a response from the skin, which indicates the absence of allergenic properties in this composition.
Optimization of UAV-Aided Millimeter-Wave IoT Systems

Due to their maneuverability, unmanned aerial vehicles (UAVs) have grown into a promising enabler of the Internet of Things (IoTs). In addition to the benefits of the bandwidth and communication quality of millimeter-wave (mmWave) systems, a UAV-aided mmWave multiple-input and multiple-output (MIMO) communication system is investigated in this paper for the data collection of IoT systems, in which single-antenna IoT devices are divided into several clusters, and the UAV aided mmWave base station (UAV-BS) collects data from each cluster using the time division scheme. The joint optimization of the beam selection, UAV trajectory, user clustering, power allocation and transmission duration is studied in this paper to improve the data collection efficiency. The solution of the problem is then given in three steps. Firstly, the incremental K-means clustering and ant colony optimization algorithm are utilized to handle the UAV trajectory planning and user clustering problem. Secondly, an incremental beam selection scheme is employed to ensure that all the devices in each cluster can communicate with the UAV. Thirdly, an iterative algorithm is proposed by alternately optimizing the power allocation and transmission duration of the IoT devices. Finally, the simulation results demonstrate the effectiveness of the proposed solution for the UAV-aided mmWave communication system.
Fault Diagnosis of Electric Motors Using Deep Learning Algorithms and Its Application: A Review

Electric motors are used extensively in numerous industries, and their failure can result not only in machine damage but also a slew of other issues, such as financial loss, injuries, etc. As a result, there is a significant scope to use robust fault diagnosis technology. In recent years, interesting research results on fault diagnosis for electric motors have been documented. Deep learning in the fault detection of electric equipment has shown comparatively better results than traditional approaches because of its more powerful and sophisticated feature extraction capabilities. This paper covers four traditional types of deep learning models: deep belief networks (DBN), autoencoders (AE), convolutional neural networks (CNN), and recurrent neural networks (RNN), and highlights their use in detecting faults of electric motors. Finally, the issues and obstacles that deep learning encounters in the fault detection mechanism as well as the prospects are discussed and summarized.
Derivative financial instruments in the activity of enterprises of the agrarian sphere of economy

The article presents the ways of strengthening the financial state, solvency, investment attractiveness and financial stability of agricultural organizations by expanding existing and finding new markets for products, additional sources of funding, wide use of derivative financial instruments and hedging in the practice of management. The subject of the research is the consideration of modern ways of bringing agricultural products from the producer to the end consumer. The purpose of the study is to reflect the possibilities of using derivative financial instruments in settlements of agricultural organizations with counterparties. In the course of the study, the concept of derivative financial instruments, which are widely used in the world stock exchange practice, but at present in Russia have not yet found wide application, is given. The economic efficiency of agricultural organizations is largely determined by the organization of sales of agricultural products, the choice of distribution channels in order to reduce the delivery time of products to consumers, improve its quality and reduce the cost of its implementation. It is concluded that in the current economic situation successful sales of agricultural products can be held through the exchange market through forward (futures) contracts for the immediate transfer of rights and obligations to perform the real delivery of agricultural products in the future on a certain date.
Viability of the Microencapsulation of Lactobacillus casei TISTR 390 Containing Inulin in Simulated Gastrointestinal Conditions and Storage

This research aimed to determine the process condition for microencapsulation of Lactobacillus casei TISTR 390 by spray drying with maltodextrin and inulin as the coating agent. The physical properties and survivability of the microencapsulated cell were evaluated under simulated gastrointestinal conditions and during storage. Firstly, 3 inlet temperatures (150, 160 and 170 ºC) and 3 maltodextrin levels (5, 10 and 15 % (w/v)) were examined. The result reveals that an optimum condition was at 160 ºC inlet temperature with 15 % maltodextrin. Subsequently, inulin was added in 3 combinations; T1 (15 % maltodextrin and 5 % inulin (w/v)), T2 (10 % maltodextrin and 10 % inulin (w/v)) and T3 (5 % maltodextrin and 15 % inulin (w/v)) in an effort to generate synbiotic powder products. The best result was observed with a combination of 10 % maltodextrin and 10 % inulin. The obtained powder had a moisture content of 1.5±0.01 %, a water activity of 0.28±0.02, a total density of 0.71±0.04 g/mL, a solubility of 84.71±0.01 %, and a lactobacilli survival rate after spray drying of 90.76 %. The microencapsulated lactobacilli containing inulin powders were able to survive in acidic (pH 2) and bile salt solution (2 % w/v) after 120 min of incubation time with more than 60 % of the cell surviving. Furthermore, the microencapsulated powders were kept in aluminum-laminated bags at room temperature for 6 weeks and it was found that the cell viability remained at 6 log CFU/g. Therefore, a combination of an equal weight of maltodextrin and inulin was a promising protection agent for L. casei TISTR 390 in the simulated gastrointestinal conditions and during storage at ambient temperature. HIGHLIGHTS Microencapsulation probiotic bacteria with prebiotic by spray drying method contribute the synbiotic microcapsule Microencapsulaiton with an equal weight of maltodextrin and inulin was promising as a protective agent to serve the survival in the gastrointestinal tract and during storage The synbiotic microcapsule can survive at room temperature for up to 6 weeks in an aluminum-laminated bag.
A Novel Technique for Low Rectal Cancer: Pushing The Anus in Laparoscopic Radical Resection

Background In sphincter-preserving surgery for low rectal cancer, it is significant to reduce the number of stapler cartilages and the incidence of anastomotic leakage. On this basis, we have developed a safer and more economical technique— pushing the anus in laparoscopic radical resection of low rectal cancer. Method From January 2015 to July 2020, 213 consecutive patients with rectal cancer received laparoscopic radical surgery. For 151 of these patients, the surgeon used the stapler cartilages (Ethicon Intraluminal Linear Staplers EC60A, Ethicon, USA) to transect the edge of tumor of the rectum (Conventional Surgery Group). And for another 62 patients, besides applying the stapler cartilages, the surgeon had the assistants push the anus forward from the perineum during the process of transecting the rectum (Pushing the Anus Group). The postoperative outcomes and complications were compared between the two groups. Results In terms of the number of the stapler cartilages, the Pushing the Anus Group was less than the Conventional Surgery Group (P<0.001). Moreover, the incidence of anastomotic leakage in the Pushing the Anus Group is lower than that in the Conventional Surgery Group (P=0.043). Conclusions With pushing the anus forward during the process of transecting the rectum, the sphincter-preserving surgery can be performed more safely and economically.
Effect of Glucosamine and Ascorbic Acid Addition on Beef Burger Textural and Sensory Attributes

1Agriculture and Agri-Food Canada, Lacombe Research and Development Centre, Lacombe, Alberta, T4L 1W1, Canada 2Department of Agricultural, Food and Nutritional Science, University of Alberta 410 Agriculture/Forestry Centre, Edmonton Alberta, T6G 2P5, Canada 3Food Processing Development Centre, Food and Bio Processing Branch, Alberta Agriculture and Forestry, Government of Alberta, Leduc, Alberta, T9E 7C5, Canada
Immunological Study of Reconstructed Common Ancestral Sequence of Adenovirus Hexon Protein

Aim: To reconstruct the ancestral sequence of human adenoviral hexon protein by combining sequence variations and structural information. And to provide a candidate hexon protein for developing new adenoviral vector capable of escaping the pre-existing immunity in healthy populations. Methods: The sequences of 74 adenovirus-type strains were used to predict the ancestral sequence of human adenovirus hexon protein using FastML and MEGA software. The three-dimensional structure model was built using homology modeling methods. The immunological features of ancestral loop 1 and loop 2 regions of sequences were tested using protein segments expressed in a prokaryotic expression system and polypeptides synthesized with human serum samples. Results: The tower region of the hexon protein had the highest sequence variability, while the neck and base regions remained constant among different types. The modern strains successfully predicted the common ancestral sequence of the human adenovirus hexon. The positive sera against neutralizing epitopes on the common ancestor of adenoviral hexon were relatively rare among healthy adults. Conclusion: The existing strains inferred the common ancestor of human adenoviruses, with epitopes never observed in the current human strains. The predicted common ancestor hexon is a good prospect in the improvement of adenovirus vectors.
Congestive kidney failure; recent knowledge and new trends

One of the possible causes of renal failure due to heart failure is congestive kidney failure (CKF). Venous congestion has a key role in the development of renal dysfunction and damage in patients with heart failure. This condition is named congestive nephropathy. In this mini-review the common causes of congestive kidney failure, its pathophysiology, histopathological changes and treatment are discussed.
Highlights of the manuscript “ Atom Probe Study of B 2 Order and A 2 Disorder in an Fe-CoMo-alloy ”

The physical and mechanical properties of intermetallic alloys can be tailored by controlling the degree of order of the solid solution by means of heat treatments. FeCo alloys with an appropriate composition exhibit an A2-disorder↔B2-order transition during continuous cooling from the disordered bcc region. The study of atomic order in intermetallic alloys by diffraction and its influence on the material properties is well established, however, investigating magnetic FeCo-based alloys by conventional methods such as X-ray diffraction is quite challenging. Thus, the imaging of ordered FeCo-nanostructures needs to be done with high resolution techniques. Transmission electron microscopy investigations of ordered FeCo domains are difficult, due to the chemical and physical similarity of Fe and Co atoms and the ferromagnetism of the samples. In this work it will be demonstrated, that the local atomic arrangement of ordered and disordered regions in an industrial Fe-Co-Mo alloy can be successfully imaged by atom probe measurements supported by field ion microscopy and transmission Kikuchi diffraction. Furthermore, a thorough atom probe parameter study will be presented and field evaporation artefacts as a function of crystallographic orientation in Fe-Co-samples will be discussed.