Miracle-dz/UniFAR-FTUs huggingface dataset:
Active surveillance in primary desmoid tumor (DT): A prospective observational study.

11570 Background: In recent years evidence of long term stabilization and spontaneous regression of primary sporadic DT resulted in a paradigm shift towards more conservative approaches. We present herein the results of an observational study aimed at prospectively assess the behavior of primary sporadic DT initially managed by active surveillance and its relation to CTNNB1 mutational status. Methods: This is an Italian prospective, multicenter, observational study (NCT 02547831) to evaluate primary sporadic DT behavior in patients (pts) >16 years with primary naive or incompletely resected and measurable disease, at any site, with CTNNB1 mutational status available. Pts were assessed by contrast enhanced MRI or CT scan at baseline, at 3, 6, 9, 12 months, then every 6 months until the third year. Tumor changes were assessed by RECIST. In case of dimensional or symptomatic progression active treatment could be proposed on an individualized basis CTNNB1 mutational status was obtained in all patients by Sanger and deep sequencing was performed in wild-type cases. Primary end-point was progression-free survival (PFS) at 3 yrs. Treatment-free survival (TFS) was also analyzed. PFS and TFS were calculated using survival analysis methods, including Kaplan-Meier plots, log-rank test for survival curves comparison, and Cox proportional-hazard multivariable regression (age, size, anatomic site and CTNNB1 mutational status). Results: From April 2013 to February 2018 108 pts were included (82% female, 18% male); median age was 39 (interquartile range, IQR 34-48) and median size 50 mm (IQR, 40-80 mm). Tumor location was: 4/108 (4%) = head&neck, 25/108 (23%) = trunk, 59/108 (55%) = abdominal wall, 3/108 (3%) = intra-abdominal, 17/108 (16%) = extremities. CTNNB1 mutations were as follow: T41A 54/108 (50%), S45F 13/108 (12%), WT 20/108 (19%), other mutations 21/108 (19%). At a m-FU of 32.3 months, the 3-year PFS was 54.5% (95% CI, 44.9%-66.1%). 42/108 (39%) pts showed a RECIST progression, with equal distribution among the different anatomic sites. None of the variables analyzed were associated to PFS. Spontaneous regression was initially observed in 27/108 (25%) patients, while it followed dimensional progression in another 33/108 (30%). 35/108 (32%) pts received active treatment, 18/42 (43%) after RECIST progression and 17/66 (26%) after symptomatic progressions. TFS at 36 months was 65.9% (95% CI, 57.3%-75.9%). S45F mutation, larger tumor size and extremity location were associated to a shorter TFS. No dimensional or symptomatic progression were observed after 36 months of FU. Conclusions: Active surveillance was marked by spontaneous regressions in 60/108 (55%) pts. An active treatment was needed in 32%. If no events occur after 3 yrs of FU, more relaxed FU schedules can be considered given the low risk of subsequent progression. Attention should be paid to patients with DT located to the extremity and/or carrying a S45F mutation. Clinical trial information: NCT 02547831.
Blockchain‐based framework for secured storage, sharing, and querying of electronic healthcare records

Medical records contain vital, critical, and confidential information of any person. Paper‐based medical records are being used by many hospitals that suffer from various issues like large physical storage requirements, limited security, and life. Electronic health records (EHRs) can transform this entire system but faces various security threats like unintentional disclosure, tampering, data leaks, lack of security mechanisms, and data access policies. Thus, there arises a need for a decentralized, tamper‐proof, and transparent healthcare network. In this article, a permissioned blockchain‐based framework using Hyperledger Fabric (HLF) is proposed, which provides secure storage, sharing, and querying of EHRs. For better data accessibility and security, algorithms have been designed to define the functionality of patients, doctors, and third‐party administrator using smart‐contracts. In the existing approaches, LevelDB (key store database) is used as a state database that is not suitable for handling complex queries. To overcome this issue, we have used CouchDB (document store database) as a state database where the search is based on keys and data values both rather than only keys. To measure the various performance indicators for this framework, a blockchain benchmark tool “Hyperledger Caliper” is used. The experimental results show the effectiveness and efficiency of the proposed framework.
Self-Assessed Effects of Pornography Use on Personal Sex Life: Results from a Large-Scale Study of Norwegian Adults

Abstract Objectives: The study explored characteristics associated with the self-assessed effects of pornography use on one’s personal sex life. Methods: Data were collected in a probability-based sample of Norwegian adults (n = 4,160). Results: Most participants (41.3%) did not believe that pornography affected their sex life. More participants reported positive (33.2%) than mixed/negative (25.5%) effects of pornography use. Sociodemographic and sexual characteristics that predicted these self-assessments were examined. Among participants in a steady relationship, emotional intimacy and relationship satisfaction were unrelated to the self-assessed effects. Conclusions: The current study findings add to scant literature about the self-assessed effects of pornography usage.
An Approach to Thresholds for Evaluating Post-Mining Site Reclamation

Here, a time-scale conceptual threshold model for assessing, evaluating, documenting, and monitoring post-mining sites reclamation progress was developed. It begins from initial state I0 down to degraded state D0 (which depends on the mining). Reclamation starts with soil reconstruction R−2 up to revegetation R−1 (red zones) to reach minimum threshold R0 (amber zone). Beyond R0 are green zones R1, R2, and R3 representing soil/abiotic conditions, biological, and improved threshold, respectively. The model also identifies potential drivers, land-use options, targets, and endpoints along the threshold reclamation ladder. It is applicable to all degraded ecosystems and adoptable in national and international laws. In this approach study, we identified threshold biotic/abiotic indicators for ascertaining success from R0, future work focuses on measurement and ascribing of threshold values to each of the threshold stage.
The effect of calorie restricted diet on anthropometric and biochemical parameters in Sprague Dawley rats

Purpose Calorie restricted diets are known to improve health and promote healthy aging. This happens because of controlled inflammation and metabolism in the body. This study aims to evaluate the differences in anthropometric and biochemical parameters in Sprague Dawley (SD) rats because of consumption of a calorie restricted diet. Design/methodology/approach The study divided SD rats (n = 15) into 3 groups consuming high calorie intake (HCI), medium calorie intake and low calorie intake (LCI). Anthropometric parameters were determined through measurement of abdominal circumference (AC), thoracic circumference (TC), body length and body weight (BW). Biochemical parameters analyzed in this study were fasting blood glucose level and full blood lipid profile. Nutritional status was obtained based on food consumption, energy intake (EI) and food efficiency rate. Measurements were taken for a period of four weeks. Findings Analysis on anthropometric parameters indicates a significant difference in mean BW between HCI (230.44 ± 1.47 g) and LCI (188.54 ± 1.50 g). There is a significant difference in abdominal TC ratio (p < 0.001; F = 13.599) in the LCI group (1.01 ± 0.00714) compared to the HCI group (1.04 ± 0.00858). Post hoc for nutrition parameters indicates a significant difference in mean EI between HCI (9.71 ± 0.006 kJ) and LCI (3.21 ± 0.001 kJ). There is a significant effect (p < 0.0001; F = 3042872.02) of EI on rats in all three groups. HDL levels were significantly higher (p < 0.0001; F = 1536.89) in the LCI group (68.60 ± 0.55 mg/dL) compared to the HCI group (49.40 ± 0.55 mg/dL). The Pearson’s correlation results show a strong positive correlation in EI with BW (p < 0.01; r = 0.988), AC (p < 0.01; r = 0.970) and body mass index (p < 0.01; r = 0.972). Originality/value Low calorie diet has been proven to affect anthropometric development and has shown improvements in biochemical parameters of the rats. This may result in healthy aging which could prevent later-life diseases.
Pendeteksi Kehadiran menggunakan ESP32 untuk Sistem Pengunci Pintu Otomatis

The design of the detection system in this study using ESP32 module that includes Wi-Fi: 802.11 b / g / n and Bluetooth: v4.2 BR / EDR and Bluetooth Low Energy (BLE). In general, the automatic door lock system using a fingerprint or RFID card in its implementation, but this study using BLE which is a component of iBeacon which has a function as a result of the fingerprint and RFID card. ESP32 have a duty to control the door lock in order to open and lock the door using relays and solenoid system, in addition to the BLE on ESP32 serves to detect the presence of individuals where Bluetooth Device Address (BD_ADDR) smartwatch or individual gadget is already registered on ESP32. Based on the experimental results, the system can detect a user's presence smartwatch on the Received Signal Strength Indicator (RSSI), which is determined on the program was uploaded to ESP32. This system can also be developed in the future and applied to a variety of special purposes such as absenteeism, indoor mapping, and smart home.
Assessment of Heavy Metals in Edible Clays Sold in Onitsha Metropolis of Anambra State, Nigeria

Aim: To determine and compare the levels of zinc (Zn), lead (Pb), cadmium (Cd), copper (Cu), mercury (Hg), and cobalt (Co) in edible clay samples. Place and Duration of Study: Department of Chemistry Laboratory, Federal College of Education (Technical), Asaba between June and October 2013. Methodology: Two species of edible clay (Nzu and Ulo) bought in replicates from four spatially located markets namely Ochanja, Ose, Relief and Okpokoin Onitsha were used for the study. The samples were digested with aqua regia solution and analyzed for heavy metals by atomic absorption spectrophotometry. Mean concentrations were computed from three replicate measurements. Data from the markets were compared by One-Way ANOVA while data between the clay types were analyzed by independent t-test. Results: Mean concentrations (ppm) of Zn, Pb, Cd, Cu, and Co showed no significant difference [(P =.981, .479, .335, .333 and .613) for Zn, Pb, Cd, Cu, and Co respectively] among markets. The mean concentration (ppm) of Hg (2.335±0.276) in Ochanja market however, differ significantly (P =.045) from those of the other markets, 0.621±0.244, Original Research Article British Journal of Applied Science & Technology, 4(14): 2114-2124, 2014 2115 0.796±0.280 and 0.251±0.190 for Ose, Relief and Okpoko respectively. Statistically reliable differences were found for Zn (P =.000) and Co (P =.003) type 1 and 11 mean concentrations. However, mean concentrations of Pb, Cd, Cu and Hg in type 1 and type 11 clays did not differ significantly [(P =.391, .288, .243, and .613) for Pb, Cd, Cu and Hg respectively]. There were high concentrations of Hg invirtually all samples and Cd in few samples. Conclusion: The high levels of Cd and Hgin the analyzed edible clays make them unhealthy for human consumption. However, further research is required to validate the reliability of these findings.
Acoustic-Lexical Characteristics of Child-Directed Speech Between 7 and 24 Months and Their Impact on Toddlers' Phonological Processing

Speech-language input from adult caregivers is a strong predictor of children's developmental outcomes. But the properties of this child-directed speech are not static over the first months or years of a child's life. This study assesses a large cohort of children and caregivers (n = 84) at 7, 10, 18, and 24 months to document (1) how a battery of phonetic, phonological, and lexical characteristics of child-directed speech changes in the first 2 years of life and (2) how input at these different stages predicts toddlers' phonological processing and vocabulary size at 2 years. Results show that most measures of child-directed speech do change as children age, and certain characteristics, like hyperarticulation, actually peak at 24 months. For language outcomes, children's phonological processing benefited from exposure to longer (in phonemes) words, more diverse word types, and enhanced coarticulation in their input. It is proposed that longer words in the input may stimulate children's phonological working memory development, while heightened coarticulation simultaneously introduces important sublexical cues and exposes them to challenging, naturalistic speech, leading to overall stronger phonological processing outcomes.
Consumer Acceptance of Brown and White Rice Varieties

Rice is consumed as a staple food by more than half of the world’s population. Due to a higher fibre and micronutrient content, brown rice is more nutritious than white rice, but the consumption of brown rice is significantly lower than that of white rice, primarily due to sensory attributes. Therefore, the present research aimed to identify the sensory attributes which drive liking of Australian-grown brown and white rice varieties. Participants (n = 139) tasted and scored (9-point hedonic scale) their liking (i.e., overall liking, aroma, colour and texture) of brown and white rice types of Jasmine (Kyeema), Low GI (Doongara), and Medium grain rice (Amaroo). In addition, participants scored aroma, colour, hardness, fluffiness, stickiness, and chewiness, on Just About Right Scales. A within-subjects crossover design with randomised order (William’s Latin Square design) was used with six repeated samples for liking and Just About Right scales. Penalty analyses were applied to determine the relative influence of perception of sensory attributes on consumer liking of the rice varieties. Across all varieties, white rice was liked more than brown rice due to the texture and colour, and Jasmine rice was preferred over Low GI and Medium Grain. Rice texture (hardness and chewiness) was the most important sensory attribute among all rice varieties and aroma was important for driving of liking between white rice varieties.
The Digital Labor of “Generation Z”: The Behavior of Contemporary College Students Using Online Media Platforms from the Perspective based on Communication Political Economy

"Generation Z" is a generation growing up in the environment of digital media and network. Under the influence of network, they gradually establish their own values and world outlook, and seek for self-identity in the vast world constructed by digital construction. Political economy of communication is a branch of communication, which is different from the empirical research path of other communication studies. It focuses on the influence of communication as an economic force on society and the control of communication activities by social political and economic authorities. From this perspective, every behavior of people hides its connotation of economics and a deeper level of criticism. It is from this perspective, this paper chose the Z generation this special group, contemporary college students as the research object, through the survey method to explore the basic characteristics of contemporary college students online media platform using behavior and objective law, trying to understand the psychological demands of related behavior behind its understanding of the behavior and for the recognition of the number of labor, Furthermore, the media literacy education of college students will be promoted faster and better, and the media literacy of college students will be comprehensively improved to help them use media in a better way.
Fresh and hardened properties of alkali-activated fly ash/slag binders: effect of fly ash source, surface area, and additives

The variation of the raw materials is critical for the wide application of alkali-activated fly ash/slag (AAFS) in practice. In this study, four fly ashes sourced from different power plants were collected and analyzed. The calcium content in fly ash had insignificant impact on setting time, flowability and compressive strength of AAFS binders when the slag content was 50%. Low calcium content in fly ash promotes the formation of C-(N)A-S-H gel with high Al substitution and improves the compressive strength at later age. It seemed that the grinding process promoted the dissolution of reactive SiO2 in fly ash, resulting in reduced setting and flowability. The replacement of silica fume promotes the formation of Si-rich C-(N)A-S-H gel with reduced gel pore size. The replacement of metakaolin accelerated the initial reaction and increased the compressive strength of binders at early age due to the reduced gel pore size in C-(N)A-S-H gel.
Estima corporal, insatisfacción corporal e índice de masa corporal en bailarinas de ballet y estudiantes

During the last decade, some authors have emphasized the importance of describing and understanding positive aspects of body image, for example, body esteem, especially in samples from different artistic-aesthetic disciplines. Therefore, the objective of the present study was to compare body esteem and body dissatisfaction, between two groups of women matched for age (ballet dancers and students) and analyze the relationship between these variables with the body mass index (BMI). Seventy women participated, with an age range of 12 to 20 years. All the participants were weighed and measured, and answered a short version of the Body Image Questionnaire and the Body Esteem Scale. The analysis of results indicated that ballet dancers have a lower body mass index (BMI), lower body dissatisfaction, and higher body esteem for physical condition and concern about weight than the students. Finally, in the group of dancers, the BMI was associated with body dissatisfaction, but not with body esteem. In contrast, in the group of students, BMI was associated with both body esteem and body dissatisfaction. The findings of the present study may have implications in the development and implementation of strategies that strengthen body esteem and body image of women who practice artistic-aesthetic disciplines.
Dynamique térahertz des nanotubes de carbone

Le developpement de circuits mesoscopiques avec une architecture hybride cette derniere decennie a permis d’etudier l’interaction lumiere matiere dans son aspect fondamental avec des photons dans le regime micro-ondes. Ces developpements permettent aujourd’hui d’etudier cette interaction dans le domaine terahertz, gamme spectrale s’etendant de 0.1 THz a 10 THz (0.4 meV-41,3 meV). L’apparition de sources performantes et de methodes de spectroscopie efficaces telles que la spectroscopie dans le domaine temporel sont des outils utilisables pour l’etude de l’interaction lumiere matiere dans ce domaine spectral. Dans ce travail de these, nous avons developpe un outil afin d’etudier cette interaction dans son aspect le plus fondamental compose d’un nanotube de carbone en regime de boite quantique et d’une cavite terahertz. Le nanotube de carbone est un element d’autant plus adapte que sa structure electronique est regie par des energies dont la frequence equivalente se situe dans le terahertz. La cavite terahertz est un "split ring resonator". Le travail s’est decompose en deux aspects, avec dans un premier temps le developpement d’un banc de spectroscopie terahertz large bande (0.3 THz-20 THz) dans le domaine temporel pour l’etude des resonateurs. En utilisant un procede original de controle du front d’onde d’emission de l’antenne, nous demontrons que le champ terahertz est focalise en limite de diffraction ce qui ouvre la possibilite d’etudier des resonateurs uniques. Dans un second temps, des mesures de transport electronique ont ete effectuees afin de mettre en evidence un couplage entre le resonateur et la boite quantique. Un couplage avec un mode bosonique est observe. La conductance de ces etats est modulee par la source de photons utilisee dans cette etude. Cependant, l’energie du mode est inferieure a celle observee par les mesures de spectroscopie ne permettant pas de conclure de maniere definitive sur l’origine de ce mode.
A wideband circularly polarized reflectarray using novel Pancharatnam‐Berry phase elements

A wideband circularly polarized reflectarray using novel single layer multi‐resonant Pancharatnam‐Berry (PB) phase elements is proposed. The unit cell consists of an I‐shaped structure and two parallel rectangular patches that generate and regulate three plasmonic resonances, which realizes broadband circular polarization (CP) maintaining reflection from 8.8 to 16 GHz. By gradually rotating the element structures, 360° phase shifts providing reflected phase in different units can be achieved due to the attractive characteristic of PB phase elements. To verify the performance of this design, a prototype of reflectarray with 41 × 41 elements is fabricated and measured. The experimental results indicate that the reflectarray has an excellent performance in terms of 66.9% 3‐dB axial ratio bandwidth, 30.5% 1‐dB gain bandwidth, 53.8% 3‐dB gain bandwidth and 52.1% peak aperture efficiency at 12.5 GHz. The design can be a promising candidate for satellite communication applications.
The Diagnostic Value of LncRNAs for Bladder Cancer: A Meta-Analysis

Background: In recent years, qualitative and quantitative analysis of LncRNA has been reported as a potential method for early diagnosis of bladder cancer, but the results from each research are insufficient and not completely consistent. This meta-analysis aims to evaluate the diagnostic value of LncRNA for BC.Methods: We conducted a diagnostic meta-analysis and the diagnostic significance of LncRNA in blood, urine and tumor tissues was discussed. We searched the PUBMED, EMABASE, and Cochrane Library until June 2020. The current meta-analysis was performed using Review Manager 5.2, Stata 16.0 and Meta-Disc 1.4 software. Results: A total of 18 researches involving early and/or advanced bladder cancer were finally included. The overall diagnostic accuracy was measured as follows: pooled sensitivity and specificity were 0.72 (95%CI:0.70, 0.73) and 0.76 (95%CI: 0.75, 0.78). Pooled positive likelihood ratio and negative likelihood ratio were 3.09 (95%CI: 2.66, 3.58) and 0.37 (95%CI: 0.33, 0.42). Combined diagnostic odds ratio was 9.43 (95%CI: 7.30, 12.20). A high diagnostic accuracy was demonstrated by the summary receiver operating characteristic curve, with area under the curve of 0.82 (95%CI: 0.78, 0.85). UCA1 and H19 had the best diagnostic effect, their diagnostic sensitivity and specificity were 80%, 79% and 79%, 73% respectively, the combined diagnostic odds ratio was 16.85 and 12.67 respectively.Conclusions: This meta-analysis suggests that LncRNA have great potential in the diagnosis of bladder cancer, UCA1 and H19 had the best diagnostic effect. LncRNA panel is the future development direction in the diagnosis of bladder cancer. However, larger sample researches are needed to further confirm our conclusion.
CAN BAICALEIN BECOME A NEW DRUG FOR COVID-19?

1 Institute of Radiology, Toxicology and Civil Protection, Faculty of Health and Social Studies, University of South Bohemia in Ceske Budejovice, Ceske Budejovice, Czech Republic 2 Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic 3 Department of Botany, Faculty of Science, Charles University in Prague, Czech Republic 4 Department of Chemistry, Faculty of Science, University of Hradec Králové, Hradec Králové, Czech Republic 5 Institute of Plant Molecular Biology, Biology Centre of the Academy of Sciences, Ceské Budejovice, Czech Republic