Miracle-dz/UniFAR-FTUs huggingface dataset:
Overview on Indian Medicinal Plants as Potential Antihypertensive agents

: Hypertension is one of the most common cardiovascular ailments that leads to weakness and precipitating factors for several other diseases. Medicinal Plants are beneficial in management of heart attacks, cerebrovascular conditions, hypertension, atherosclerosis and heart failure. Traditional plant-based medicines are used in management of Hypertension. Apium graveolens, Cinnamon Cinnamomum zeylanicum, Rauwolfia serpentina are few medicinal plants with blood pressure lowering effects. The popularity of natural products is increasing day by day due to their lower side effect and cost effectiveness. This review explains seventeen medicinal plants which are used by pastoral and ethnical and tribal peoples of India for cure and management of hypertension. The data was collected through extensive literature reviews. This review has been arranging in a systemic way such as vernacular name, botanical name, family, different part used with their mechanism of action. hypoglycaemic, calyx, the SBP Hg, In mild and pre-hypertensive patients, using hibiscus tea (240 ml) 3 times daily for six weeks decreased SBP, DBP, and MAP considerably by 7.2, 3.1-, and 4.5-mm Hg, respectively. [63] Previous studies showed that on treatment with HS the SBP and DBP level declined dose dependently in salt induced hypertensive and in the normotensive group. When comparing to ACE-inhibitors, it was equally effective to captopril but less effective than lisinopril. [65] Its effects were facilitated through the elevated production of NO, blocking of Ca 2+ channels, and opening of KATP channels. The water-soluble active constituents of HS, anthocyanins, predominantlycyanidin-3-sambubiosideand delphinidin-3-sambubioside, are responsible for the hypocholesterolaemia, antioxidant & antihypertensive effect. anti-depressant, antitussive, anticonvulsant, hypolipidemic, anxiolytic, anticancer, and antioxidant. picrocrocin show anti-hypertensive property by of by 1.98 1.92,
How to Become a Mini-moon: Some Hints from 2022 NX1

Low-velocity encounters between our planet and any near-Earth object (NEO) in an Earth-like orbit may induce its temporary capture as a mini-moon. Such mini-moon episodes could lead the NEO to complete one or more revolutions around Earth when gravitationally bound, a temporarily-captured orbiter, like in the cases of 2006 RH120 and 2020 CD3; sometimes not even one revolution is completed, a temporarily-captured flyby, like in the case of 1991 VG. Asteroid 2022 NX1 experienced a temporarily-captured flyby in 1981, has had another one in 2022, and will become a temporarily-captured orbiter in 2051. This object occupies the edge of Earth’s co-orbital space and sometimes it approaches us following a horseshoe path.
Knowledge, attitudes, and health status of childbearing age young women regarding preconception health - an Italian survey

Summary Introduction Preconception health is a public health issue, concerning aspects that could have repercussions on pregnancy outcomes. Despite the importance, often there is a lack of knowledge, particularly among young women. This cross-sectional study aims to evaluate knowledge, attitudes and health status of young women regarding preconception health in the Italian context. Methods From July 2020 until April 2021 a validated questionnaire (systematic review, Delphi procedure and pilot study) was administered to a sample of 340 women aged 18 to 25 years, without previous pregnancy and not planning it, attending secondary grade schools and universities. It collected information on knowledge, physical, sexual and mental health. T-test and analysis of variance (ANOVA) were used to determine a significant difference in knowledge mean score (KMS) among different groups. Results KMS was 67.6% (SD = 18.1). Participants with Italian nationality, enrolled in a health-field university, with a full-time job, a family income higher than 35,000 €/year and teachers or health providers as information source, had a significantly higher KMS. Only 15.9% of women who saw a gynaecologist in the last year (47.7%) asked about preconception health. 56.5% knew that folic acid is effective in reducing the risk of neural tube defects, while 5.9% was taking it. 82.3% was living in stressing environment. Gender-based discrimination at work, school or family was felt by 25.1%, while 38.2% experienced at least one type of violence. Conclusions Promoting preconception health by improving knowledge, attitudes and behaviours may be an impactful possibility to improve women’s, children’s, and communities’ health.
Review of Power Conversion and Energy Management for Low-Power, Low-Voltage Energy Harvesting Powered Wireless Sensors

In this paper, state-of-the-art power electronics and energy management solutions utilized in low-power (less than 5 mW), low-voltage (less than 3 V) energy harvesting powered wireless sensors for Internet of things related applications are detailed. All aspects of an energy harvesting powered sensor system are examined, including the challenges of low-power energy harvesting sources, energy management circuits including power converters and energy storage elements, as well as the impact of wireless sensor pulsed power profiles. In particular, this paper focuses on existing voltage step-up energy management techniques, including the issues of cold-start and maximum power point tracking, as well as energy storage which is necessary for wireless sensor operation. Both academic and commercially available energy harvesting powered systems are examined to provide a comprehensive analysis of existing solutions. Issues that are limiting the current system performance are identified to help define future developments needed to enable efficient and effective energy harvesting powered wireless sensor operation.
The Implications of Incongruence between Gene Tree and Species Tree Topologies for Divergence Time Estimation

Abstract Phylogenetic analyses are increasingly being performed with data sets that incorporate hundreds of loci. Due to incomplete lineage sorting, hybridization, and horizontal gene transfer, the gene trees for these loci may often have topologies that differ from each other and from the species tree. The effect of these topological incongruences on divergence time estimation has not been fully investigated. Using a series of simulation experiments and empirical analyses, we demonstrate that when topological incongruence between gene trees and the species tree is not accounted for, the temporal duration of branches in regions of the species tree that are affected by incongruence is underestimated, whilst the duration of other branches is considerably overestimated. This effect becomes more pronounced with higher levels of topological incongruence. We show that this pattern results from the erroneous estimation of the number of substitutions along branches in the species tree, although the effect is modulated by the assumptions inherent to divergence time estimation, such as those relating to the fossil record or among-branch-substitution-rate variation. By only analyzing loci with gene trees that are topologically congruent with the species tree, or only taking into account the branches from each gene tree that are topologically congruent with the species tree, we demonstrate that the effects of topological incongruence can be ameliorated. Nonetheless, even when topologically congruent gene trees or topologically congruent branches are selected, error in divergence time estimates remains. This stems from temporal incongruences between divergence times in species trees and divergence times in gene trees, and more importantly, the difficulty of incorporating necessary assumptions for divergence time estimation. [Divergence time estimation; gene trees; species tree; topological incongruence. ]
Ultracold strongly coupled gas: A near-ideal liquid

Feshbach resonances of trapped ultracold alkali-metal atoms allow to vary the atomic scattering length a. At very large values of a the system enters an universal strongly coupled regime in which its properties--the ground-state energy, pressure, etc.--become independent of a. We discuss the transport properties of such systems. In particular, the universality arguments imply that the shear viscosity of ultracold Fermi atoms at the Feschbach resonance is proportional to the particle number density n and the Plank constant ({Dirac_h}/2{pi}): {eta}=({Dirac_h}/2{pi})n{alpha}{sub {eta}}, where {alpha}{sub {eta}} is a universal constant. Using Heisenberg uncertainty principle and Einstein's relation between diffusion and viscosity we argue that the viscosity has the lower bound given by {alpha}{sub {eta}}{<=}(6{pi}){sup -1}. We relate the damping of low-frequency density oscillations of ultracold optically trapped {sup 6}Li atoms to viscosity and find that the value of the coefficient {alpha}{sub {eta}} is about 0.3. We also show that such a small viscosity cannot be explained by kinetic theory based on binary scattering. We conclude that the system of ultracold atoms near the Feshbach resonance is a near-ideal liquid.
Evolution of X-ray and optical properties of galaxy clusters

This thesis is comprised of X-ray and optical studies of 27 X-ray selected galaxy clusters from the XMM-LSS survey. These systems are mostly groups and poor clusters, with temperatures 0.6-4.8 keV, spanning the redshift range 0.05 to 1.05, hence these are some of the highest redshift X-ray selected clusters to have been studied. In the X-ray study, the evolution in the X-ray surface brightness profiles of the hot intracluster plasma is studied. Comparing the profiles with a standard -model it is found that 54% of the sample possess cuspy (cool) cores. Trends with both temperature and redshift in the outer slope beta of the X-ray surface brightness and in the incidence of cuspy cores are investigated. Fits indicate that the incidence of cuspy cores does not decline at high redshifts, as has been reported in rich clusters. Rather such cores become more prominent with increasing redshift. It is also found that has a positive correlation with temperature. In the optical study, CFHTLS optical photometry has been used to study the galaxy luminosity functions of 14 members of the sample. Individual luminosity functions (LFs) as well as redshift-stacked and temperature-stacked LFs in three filters, g', r' and z', down to M = -14:5 are derived. All LFs were fitted by Schechter functions which well-constrained the faint-end slope, . Derived values of ranged from -:03 to as steep as -2:1. No evidence is found for upturns at faint magnitudes. Evolution in was apparent in all bands: it becomes shallower with increasing redshift. It is found that at z~0:3, alpha is steeper (-1.67) in the green (g') band than it is (-1.30) in the red (z') band. This colour trend disappears at low redshift, which is attributed to reddening of faint blue galaxies from z ~0.3 to z~0. Also, the total optical luminosity is calculated and is found to correlate strongly with X-ray luminosity and temperature, which is consistent with expectations for self-similar clusters with constant mass-to-light ratio.
Functional Trade-offs Asymmetrically Promote Phenotypic Evolution.

Trade-offs are thought to bias evolution and are core features of many anatomical systems. Therefore, trade-offs may have far-reaching macroevolutionary consequences, including patterns of morphological, functional, and ecological diversity. Jaws, like many complex anatomical systems, are comprised of elements involved in biomechanical trade-offs. We test the impact of a core mechanical trade-off, transmission of velocity versus force (i.e., mechanical advantage), on rates of jaw evolution in Neotropical cichlids. Across 130 species representing a wide array of feeding ecologies, we find that the velocity-force trade-off impacts evolution of the surrounding jaw system. Specifically, rates of jaw evolution are faster at functional extremes than in more functionally intermediate or unspecialized jaws. Yet, surprisingly, the effect on jaw evolution is uneven across the extremes of the velocity-force continuum. Rates of jaw evolution are 4 to 10-fold faster in velocity-modified jaws, whereas force-modified jaws are 7 to 18-fold faster, compared to unspecialized jaws, depending on the extent of specialization. Further, we find that a more extreme mechanical trade-off resulted in faster rates of jaw evolution. The velocity-force trade-off reflects a gradient from specialization on capture-intensive (e.g., evasive or buried) to processing-intensive prey (e.g., attached or shelled), respectively. The velocity extreme of the trade-off is characterized by large magnitudes of trait change leading to functionally divergent specialists and ecological stasis. By contrast, the force extreme of the trade-off is characterized by enhanced ecological lability made possible by phenotypes more readily co-opted for different feeding ecologies. This asymmetry of macroevolutionary outcomes along each extreme is likely the result of an enhanced utility of the pharyngeal jaw system as force-modified oral jaws are adapted for prey that require intensive processing (e.g., algae, detritus, and molluscs). The velocity-force trade-off, a fundamental feature of many anatomical systems, promotes rapid phenotypic evolution of the surrounding jaw system in a canonical continental adaptive radiation. Considering that the velocity-force trade-off is an inherent feature of all jaw systems that involve a lower element that rotates at a joint, spanning the vast majority of vertebrates, our results may be widely applicable across the tree of life. [adaptive radiation; constraint; decoupling; jaws; macroevolution; specialization].
Breath response following a nutritional challenge monitored by secondary electrospray ionization high-resolution mass spectrometry

On-line breath analysis using secondary electrospray ionization coupled to high-resolution mass spectrometry (SESI-HRMS) is a sensitive method for biomarker discovery. The strengths of this technology have already been demonstrated in the clinical environment. For the first time, this study demonstrates the application of SESI-HRMS in the field of nutritional science using a standardized nutritional intervention, consisting of a high-energy shake (950 kcal, 8% protein, 35% sugar and 57% fat). Eleven subjects underwent the intervention on three separate days and their exhaled breath was monitored up to six hours postprandially. In addition, sampling was performed during equivalent fasting conditions for selected subjects. To estimate the impact of inter- and intra-individual variability, analysis of variance simultaneous component analysis was conducted, revealing that the inter-individual variability accounted for 30% of the data variation. To distinguish the effect of the intervention from fasting conditions, partial least squares discriminant analysis was performed. Candidate compound annotation was performed with pathway analysis and collision-induced dissociation (CID) experiments. Pathway analysis highlighted, among others, features associated with the metabolism of linoleate, butanoate and amino sugars. Tentative compounds annotated through CID measurements include fatty acids, amino acids, and amino acid derivatives, some of them likely derived from nutrients by the gut microbiome (e.g. propanoate, indoles), as well as organic acids from the Krebs cycle. Time-series clustering showed an overlap of observed kinetic trends with those reported previously in blood plasma.
Elotuzumab Plus Pomalidomide and Dexamethasone for Relapsed/Refractory Multiple Myeloma: Final Overall Survival Analysis From the Randomized Phase II ELOQUENT-3 Trial

PURPOSE In the phase II ELOQUENT-3 trial (ClinicalTrials.gov identifier: NCT02654132), elotuzumab combined with pomalidomide/dexamethasone (EPd) significantly improved progression-free survival (PFS) versus pomalidomide/dexamethasone (Pd) in patients with relapsed/refractory multiple myeloma (RRMM) previously treated with lenalidomide and a proteasome inhibitor (PI). Here, we present the final overall survival (OS) results. METHODS Patients with RRMM who had received ≥ 2 prior lines of therapy, with disease refractory to last therapy and either refractory or relapsed and refractory to lenalidomide and a PI were randomly assigned (1:1) to receive EPd or Pd. The primary end point was PFS per investigator assessment. ORR and OS were secondary end points planned to be tested hierarchically. RESULTS A total of 117 patients were randomly assigned to EPd (n = 60) and Pd (n = 57). Among treated patients (EPd 60, Pd 55), there were 37 (61.7%) deaths in the EPd group and 41 (74.5%) in the Pd group, most commonly because of disease progression (EPd 41.7%, Pd 49.1%). Median (95% CI) OS was significantly improved with EPd (29.8 [22.9 to 45.7] months) versus Pd (17.4 [13.8 to 27.7] months), with a hazard ratio of 0.59 (95% CI, 0.37 to 0.93; P = .0217). OS benefit with EPd was observed in most patient subgroups. The safety profile of EPd was consistent with prior reports with no new safety signals detected. CONCLUSION EPd demonstrated a statistically significant improvement in OS versus Pd in patients with RRMM previously treated with lenalidomide and a PI who had disease refractory to last therapy. In this setting, ELOQUENT-3 is the first randomized study of a triplet regimen incorporating a monoclonal antibody and Pd to improve both PFS and OS significantly.
Hydrogen Gas Inhalation Attenuates Acute Impulse Noise Trauma: A Preclinical In Vivo Study

Objective: Molecular hydrogen (H2) has shown therapeutic potential in several oxidative stress-related conditions in humans, is well-tolerated, and is easily administered via inhalation.The aim of this preclinical in vivo study was to investigate whether impulse noise trauma can be prevented by H2 when inhaled immediately after impulse noise exposure. Methods: Guinea pigs (n = 26) were subjected to impulse noise (n = 400; 156 dB SPL; 0.33/s; n = 11; the Noise group), to impulse noise immediately followed by H2 inhalation (2 mol%; 500 ml/min; 1 hour; n = 10; the Noise + H2 group), or to H2 inhalation (n = 5; the H2 group). The acoustically evoked ABR threshold at 3.15, 6.30, 12.5, 20.0, and 30.0 kHz was assessed before and 4 days after impulse noise and/or H2 exposure. The cochleae were harvested after the final ABR assessment for quantification of hair cells. Results: Noise exposure caused ABR threshold elevations at all frequencies (median 35, 35, 30, 35, and 35 dB SPL, the Noise group; 20, 25, 10, 13, and 20 dB SPL, the Noise + H2 group; P < .05) but significantly less so in the Noise + H2 group (P < .05). Outer hair cell (OHC) loss was in the apical, mid, and basal regions 8.8%, 53%, and 14% in the Noise group and 3.5%, 22%, and 1.2% in the Noise + H2 group. The corresponding inner hair cell (IHC) loss was 0.1%, 14%, and 3.5% in the Noise group and 0%, 2.8%, and 0% in the Noise + H2 group. The difference between the groups was significant in the basal region for OHCs (P = .003) and apical (P = .033) and basal (P = .048) regions for IHCs. Conclusions: Acute acoustic trauma can be reduced by H2 when inhaled immediately after impulse noise exposure.
CROSS-REACTIVITY TO ANTIBIOTICS: PROPOSITIONS FOR SELECTING ALTERNATIVES.

OBJECTIVE The aim: To analyze CR among antibacterials of different classes and to overcome some widespread misconceptions regarding CR between different classes of antibiotics. PATIENTS AND METHODS Materials and methods: The narrative review represents an assessment of the most pertinent literary sources published in English language, which dealt with the issues of cross-reactivity between individual antibiotics and different classes of these ones. CONCLUSION Conclusions: With a high probability of type I AR in a patient in the past, it is better to plan the treatment of patients together with an allergist / immunologist. If this probability is estimated to be low, the choice of a particular antibiotic may be based to some extent on CR data.
Can maternal hormones play a significant role in delivery mode?

Abstract The aim of this study was primarily to evaluate the levels of progesterone, oestradiol and relaxin during different delivery modes and secondarily to assess specific traits and changes in maternal pelvic dimensions during pregnancy and childbirth, in correlation with foetal size and maternal hormonal profile. Nulliparous women (n = 448) were evaluated at three different stages, during first trimester, at the time of admission for childbirth and finally just before childbirth. Each examination included clinical internal pelvimetry, blood sample collection for defining the hormones levels in peripheral maternal circulation and ultrasonographic measurements of specific variables of the pubic symphysis and the foetus. We included 304 nulliparous women divided in three groups. According to our results, there was statistically significant difference at the mean progesterone, oestradiol and relaxin range during different modes of childbirth (p-value < .01). We also found significant correlation between the newborn’s weight and the changes in pubic symphysis dimensions. However, no significant association was noted between maternal hormones studied and the changes in pelvic dimensions. IMPACT STATEMENT What is already known on this subject? Mode of childbirth can be affected by various aspects, like maternal pelvic anatomy, foetal size and hormonal status at the time of labour. Hormonal fluctuations along with mechanical forces caused by the foetus are believed to lead to morphological alterations to promote natural vaginal childbirth. What do the results of this study add? Our results clearly showed that successful vaginal delivery is characterised by the prevalence of a hyperoestrogenic environment with higher values of intrapartum oestradiol range and significant increase in maternal serum relaxin levels. We also proved that progesterone levels do not decrease during vaginal childbirth, and we concluded that foetal size seems to be the most crucial factor causing alterations in maternal pelvis during parturition. What are the implications of these findings for clinical practice and further research? Our findings could form part of a set of key factors included in future algorithms or computerised biomechanical models for predicting potential childbirth mode. Larger multicenter studies should confirm our results and evaluate their clinical significance in the decision making to ensure safe childbirth and optimal maternal and perinatal outcomes.