Miracle-dz/UniFAR-FTUs huggingface dataset:
Advanced battery management system design for SOC / SOH estimation for e-bikes applications

In this work, state of charge (SOC) and state of health (SOH) estimation algorithms for battery management system are proposed and compared. These algorithms are developed on a battery pack designed specifically for light electric vehicle (electric scooter or bicycles) applications. The advanced battery management system is designed in order to evaluate the instantaneous charge available in the battery and at the same time to monitor the slowly varying battery aging parameters. Two SOC estimation algorithms are proposed: an extended Kalman filter (EKF) and an adaptive extended Kalman filter (AEKF). With the adaptive version of Kalman filter a proper value of the model noise covariance is adaptively set using the information coming from the online innovation analysis. In the second part of this paper, a new estimation algorithm based on least squares is proposed to estimate the battery SOH. A general framework for a combined evaluation of SOC/SOH is discussed.
Characterizing the Commercial Avionics Thermal Environment for Field Reliability Assessment

Defining environmental loading is often the most uncertain part of the electronics reliability calculation. This paper demonstrates a practical methodology to measure and characterize the dynamic thermal history of the commercial airplane environment. To reduce irregular field thermal cycles, an algorithm is presented that preserves key information necessary for viscoplastic solder fatigue analysis. As an example. the IPC solder model will be used to evaluate 20 termination leadless ceramic chip carriers on nonconstrained printed wiring boards. This methodology will enable more realistic thermal fatigue reliability assessments and acceleration test specifications.
4.3.2 Requirements Definition ‐ A Plea For a Return To English

The formulation of requirements continues to be a problem in systems engineering, despite considerable efforts over the last several decades and the emergence of a number of formalised languages. In this paper, we argue that a natural language, i.e. English, is still the most appropriate for most cases, and that it would be beneficial to concentrate more effort on ensuring the proper use of English rather than on inventing new formalisms to circumvent the perceived weaknesses of English.
达雷妥尤单抗治疗晚期轻链型淀粉样变的疗效和安全性

目的 回顾性分析晚期轻链（AL）型淀粉样变患者接受达雷妥尤单抗治疗的疗效和安全性。 方法 纳入20例于2017年1月至2021年3月在北京协和医院接受达雷妥尤单抗治疗的初治或复发难治晚期AL型淀粉样变患者。 收集患者治疗前基线临床资料及治疗随访资料，分析患者的血液学、器官缓解情况，预后及不良反应。 结果 20例患者的中位年龄为62（45～73）岁，男女比例2. 3∶1，9例为初治，11例为复发难治，梅奥2004分期为Ⅱ/Ⅲ期。 4例患者于第1个疗程死亡，其余16例患者中位接受3（1～10）个疗程化疗。 治疗后1个月、3个月及6个月血液学总缓解率均为80％，≥非常好的部分缓解率分别为45％、60％及60％，中位血液学起效时间为13（6～28）d，3个月、6个月及12个月心脏缓解率分别为20％、30％及40％，中位起效时间为91（30～216）d，1年总生存率为48. 4％。 至末次随访，9例（45％）患者死亡，1个月内死亡率为25％，Ⅲb期患者1个月内死亡率为40％。 3级以上血液学不良反应以淋巴细胞减少最为常见，非血液学不良反应主要为输注反应及感染。 结论 达雷妥尤单抗治疗初治及复发难治晚期AL型淀粉样变可快速诱导高水平的血液学缓解，但Ⅲb期患者仍有较高的早期死亡率。
Non O1/ O139 Vibrio Cholerae Septicemia in a Patient with Hepatocellular Carcinoma

BACKGROUND: An elderly male with underlying Hepatocellular carcinoma came with history of fall with head and ear trauma, vomiting, abdominal pain, fatigue. Patient died within hours due to Septic shock Blood culture grew Non O1/O139 Vibrio cholerae which was later found to be non-toxigenic. This was a lethal case of non-O1/non-O139 V. cholerae sepsis and we focus on the dilemmas in identification and management of this rare bacterium.
Diagnostic validity and clinical utility of genetic testing for hypertrophic cardiomyopathy: a systematic review and meta-analysis

Objective This study summarises the diagnostic validity and clinical utility of genetic testing for patients with hypertrophic cardiomyopathy (HCM) and their at-risk relatives. Methods A systematic search was performed in PubMed (MEDLINE), Embase, CINAHL and Cochrane Central Library databases from inception through 2 March 2020. Subgroup and sensitivity analyses were prespecified for individual sarcomere genes, presence/absence of pathogenic variants, paediatric and adult cohorts, family history, inclusion of probands, and variant classification method. Study quality was assessed using the Newcastle-Ottawa tool. Results A total of 132 articles met inclusion criteria. The detection rate based on pathogenic and likely pathogenic variants was significantly higher in paediatric cohorts compared with adults (56% vs 42%; p=0.01) and in adults with a family history compared with sporadic cases (59% vs 33%; p=0.005). When studies applied current, improved, variant interpretation standards, the adult detection rate significantly decreased from 42% to 33% (p=0.0001) because less variants met criteria to be considered pathogenic. The mean difference in age-of-onset in adults was significantly earlier for genotype-positive versus genotype-negative cohorts (8.3 years; p<0.0001), MYH7 versus MYBPC3 cohorts (8.2 years; p<0.0001) and individuals with multiple versus single variants (7.0 years; p<0.0002). Overall, disease penetrance in adult cohorts was 62%, but differed significantly depending on if probands were included or excluded (73% vs 55%; p=0.003). Conclusions This systematic review and meta-analysis is the first, to our knowledge, to collectively quantify historical understandings of detection rate, genotype-phenotype associations and disease penetrance for HCM, while providing the answers to important routine clinical questions and highlighting key areas for future study.
Associations of Phthalate Metabolites and Bisphenol A Levels with Obesity in Children: The Korean National Environmental Health Survey (KoNEHS) 2015 to 2017

Background Phthalates and bisphenol A (BPA) are synthetic chemicals widely used in daily life. This study investigated urinary phthalate and BPA levels in Korean children and their associations with obesity. Methods A total of 2,351 children aged 3 to 17 years who participated in the Korean National Environmental Health Survey 2015 to 2017 were included. Urinary dilution was corrected using covariate-adjusted standardization (CAS). We examined the geometric mean (GM) concentrations of urinary phthalate metabolites, including di (2-ethylhexyl) phthalate (DEHP) metabolites (mono [2-ethyl-5-hydroxyhexyl] phthalate, mono [2-ethyl-5-oxohexyl] phthalate, and mono [2-ethyl-5-carboxypentyl] phthalate [MECPP]), mono-benzyl-phthalate (MBzP), mono (carboxyoctyl) phthalate (MCOP), mono (carboxy-isononyl) phthalate (MCNP), mono (3-carboxypropyl) phthalate, and mono-n-butyl-phthalate (MnBP), and BPA. We also analyzed the odds ratio (OR) for obesity according to the quartiles of each analyte. Results The urinary GM levels of DEHP metabolites and MnBP were notably higher among Korean children than among American, Canadian, and German children. The CAS-applied GM concentrations of most analytes, except for MBzP, MCOP, and MCNP, were higher in children aged 3 to 5 years than in those aged 6 to 17 years. The OR for obesity in the highest quartile of MECPP was significantly higher than in the lowest quartile after adjusting for covariates. However, the other phthalate metabolites and BPA were not significantly associated with obesity. Conclusion The concentrations of urinary DEHP metabolites and MnBP were higher in Korean children than in children in Western countries. Urinary MECPP exposure, but not other phthalates or BPA, showed a positive association with obesity in Korean children. Further studies are required to elucidate the causal relationships.
Genetics of osteopontin in patients with chronic kidney disease: The German Chronic Kidney Disease study

Osteopontin (OPN), encoded by SPP1, is a phosphorylated glycoprotein predominantly synthesized in kidney tissue. Increased OPN mRNA and protein expression correlates with proteinuria, reduced creatinine clearance, and kidney fibrosis in animal models of kidney disease. But its genetic underpinnings are incompletely understood. We therefore conducted a genome-wide association study (GWAS) of OPN in a European chronic kidney disease (CKD) population. Using data from participants of the German Chronic Kidney Disease (GCKD) study (N = 4,897), a GWAS (minor allele frequency [MAF]≥1%) and aggregated variant testing (AVT, MAF<1%) of ELISA-quantified serum OPN, adjusted for age, sex, estimated glomerular filtration rate (eGFR), and urinary albumin-to-creatinine ratio (UACR) was conducted. In the project, GCKD participants had a mean age of 60 years (SD 12), median eGFR of 46 mL/min/1.73m2 (p25: 37, p75: 57) and median UACR of 50 mg/g (p25: 9, p75: 383). GWAS revealed 3 loci (p<5.0E-08), two of which replicated in the population-based Young Finns Study (YFS) cohort (p<1.67E-03): rs10011284, upstream of SPP1 encoding the OPN protein and related to OPN production, and rs4253311, mapping into KLKB1 encoding prekallikrein (PK), which is processed to kallikrein (KAL) implicated through the kinin-kallikrein system (KKS) in blood pressure control, inflammation, blood coagulation, cancer, and cardiovascular disease. The SPP1 gene was also identified by AVT (p = 2.5E-8), comprising 7 splice-site and missense variants. Among others, downstream analyses revealed colocalization of the OPN association signal at SPP1 with expression in pancreas tissue, and at KLKB1 with various plasma proteins in trans, and with phenotypes (bone disorder, deep venous thrombosis) in human tissue. In summary, this GWAS of OPN levels revealed two replicated associations. The KLKB1 locus connects the function of OPN with PK, suggestive of possible further post-translation processing of OPN. Further studies are needed to elucidate the complex role of OPN within human (patho)physiology.
Glowing Sucker Octopus (Stauroteuthis syrtensis)‐Inspired Soft Robotic Gripper for Underwater Self‐Adaptive Grasping and Sensing

A soft gripper inspired by the glowing sucker octopus (Stauroteuthis syrtensis)’ highly evolved grasping capability enabled by the umbrella‐shaped dorsal and ventral membrane between each arm is presented here, comprising of a 3D‐printed linkage mechanism used to actuate a modular mold silicone‐casting soft suction disc to deform. The soft gripper grasp can lift objects using the suction generated by the pump in the soft disc. Moreover, the protruded funnel‐shaped end of the deformed suctorial mouth can adapt to smooth and rough surfaces. Furthermore, when the gripper contacts the submerged target objects in a turbid environment, local suctorial mouth arrays on the suction disc are locked, causing the variable flow inside them, which can be detected as a tactile perception signal to the target objects instead of visual perception. Aided by the 3D‐printed linkage mechanism, the soft gripper can grasp objects of different shapes and dimensions, including flat objects, objects beyond the grasping range, irregular objects, scattered objects, and a moving turtle. The results report the soft gripper's versatility and demonstrate the vast application potentials of self‐adaptive grasping and sensing in various environments, including but are not limited to underwater, which is always a key challenge of grasping technology.
Changes in Container-Breeding Mosquito Diversity and Abundance Along an Urbanization Gradient are Associated With Dominance of Arboviral Vectors

Abstract Environmental conditions associated with urbanization are likely to influence the composition and abundance of mosquito (Diptera, Culicidae) assemblages through effects on juvenile stages, with important consequences for human disease risk. We present six years (2011–2016) of weekly juvenile mosquito data from distributed standardized ovitraps and evaluate how variation in impervious cover and temperature affect the composition and abundance of container-breeding mosquito species in Maryland, USA. Species richness and evenness were lowest at sites with high impervious cover (>60% in 100-m buffer). However, peak diversity was recorded at sites with intermediate impervious cover (28–35%). Four species were observed at all sites, including two recent invasives (Aedes albopictus Skuse, Ae. japonicus Theobald), an established resident (Culex pipiens L), and one native (Cx. restuansTheobald). All four are viral vectors in zoonotic or human transmission cycles. Temperature was a positive predictor of weekly larval abundance during the growing season for each species, as well as a positive predictor of rapid pupal development. Despite being observed at all sites, each species responded differently to impervious cover. Abundance of Ae. albopictus larvae was positively associated with impervious cover, emphasizing that this medically-important vector not only persists in the warmer, impervious urban landscape but is positively associated with it. Positive temperature effects in our models of larval abundance and pupae occurrence in container habitats suggest that these four vector species are likely to continue to be present and abundant in temperate cities under future temperature scenarios.
Mini-Open Lateral Approach for Corpectomy in the Thoracolumbar Spine

The thoracolumbar spine poses unique challenges when considering surgical treatment options. In the era of modern medicine, nonoperative treatments have become more available for pathology of the thoracolumbar spine, including infectious, oncologic, traumatic, and degenerative etiologies. However, surgery is often warranted in the presence of deformity or with spinal cord compression resulting in neurologic deficits. Traditionally, posterior or anterior approaches were used for surgical treatment in the thoracolumbar spine. The mini-open lateral approach for corpectomy in the thoracolumbar spine is relatively new but not yet widely utilized, is less invasive, and is a less morbid surgical option for treating what has historically been a challenging surgical location. A thorough understanding of the anatomy associated with this approach is essential to perform safe and successful surgery with this technique. This review outlines the preoperative and anatomical considerations, surgical technique, contraindications, potential complications, and clinical outcomes associated with performing corpectomies in the thoracolumbar spine via the mini-open lateral approach. This is a safe, successful, and appealing surgical option for appropriately selected patients with diseases of the thoracolumbar region.
Tri-branched gels: Rubbery materials with the lowest branching factor approach the ideal elastic limit

Unlike hard materials such as metals and ceramics, rubbery materials can endure large deformations due to the large conformational degree of freedom of the cross-linked polymer network. However, the effect of the network’s branching factor on the ultimate mechanical properties has not yet been clarified. This study shows that tri-branching, which entails the lowest branching factor, results in a large elastic deformation near the theoretical upper bound. This ideal elastic limit is realized by reversible strain-induced crystallization, providing on-demand reinforcement. The enhanced reversible strain-induced crystallization is observed in the tri-branched and not in the tetra-branched network. A mathematical theory of structural rigidity is used to explain the difference in the chain orientation. Although tetra-branched polymers have been preferred since the development of vulcanization, these findings highlighting the merits of tri-branching will prompt a paradigm shift in the development of rubbery materials.
Privacy preserving validation for multiomic prediction models

Abstract Reproducibility of results obtained using ribonucleic acid (RNA) data across labs remains a major hurdle in cancer research. Often, molecular predictors trained on one dataset cannot be applied to another due to differences in RNA library preparation and quantification, which inhibits the validation of predictors across labs. While current RNA correction algorithms reduce these differences, they require simultaneous access to patient-level data from all datasets, which necessitates the sharing of training data for predictors when sharing predictors. Here, we describe SpinAdapt, an unsupervised RNA correction algorithm that enables the transfer of molecular models without requiring access to patient-level data. It computes data corrections only via aggregate statistics of each dataset, thereby maintaining patient data privacy. Despite an inherent trade-off between privacy and performance, SpinAdapt outperforms current correction methods, like Seurat and ComBat, on publicly available cancer studies, including TCGA and ICGC. Furthermore, SpinAdapt can correct new samples, thereby enabling unbiased evaluation on validation cohorts. We expect this novel correction paradigm to enhance research reproducibility and to preserve patient privacy.
Microbial Biogeochemical Cycling of Nitrogen in Arid Ecosystems

Arid ecosystems cover ∼40% of the Earth’s terrestrial surface and store a high proportion of the global nitrogen (N) pool. They are low-productivity, low-biomass, and polyextreme ecosystems, i.e., with (hyper)arid and (hyper)oligotrophic conditions and high surface UV irradiation and evapotranspiration. These polyextreme conditions severely limit the presence of macrofauna and -flora and, particularly, the growth and productivity of plant species. SUMMARY Arid ecosystems cover ∼40% of the Earth’s terrestrial surface and store a high proportion of the global nitrogen (N) pool. They are low-productivity, low-biomass, and polyextreme ecosystems, i.e., with (hyper)arid and (hyper)oligotrophic conditions and high surface UV irradiation and evapotranspiration. These polyextreme conditions severely limit the presence of macrofauna and -flora and, particularly, the growth and productivity of plant species. Therefore, it is generally recognized that much of the primary production (including N-input processes) and nutrient biogeochemical cycling (particularly N cycling) in these ecosystems are microbially mediated. Consequently, we present a comprehensive survey of the current state of knowledge of biotic and abiotic N-cycling processes of edaphic (i.e., open soil, biological soil crust, or plant-associated rhizosphere and rhizosheath) and hypo/endolithic refuge niches from drylands in general, including hot, cold, and polar desert ecosystems. We particularly focused on the microbially mediated biological nitrogen fixation, N mineralization, assimilatory and dissimilatory nitrate reduction, and nitrification N-input processes and the denitrification and anaerobic ammonium oxidation (anammox) N-loss processes. We note that the application of modern meta-omics and related methods has generated comprehensive data sets on the abundance, diversity, and ecology of the different N-cycling microbial guilds. However, it is worth mentioning that microbial N-cycling data from important deserts (e.g., Sahara) and quantitative rate data on N transformation processes from various desert niches are lacking or sparse. Filling this knowledge gap is particularly important, as climate change models often lack data on microbial activity and environmental microbial N-cycling communities can be key actors of climate change by producing or consuming nitrous oxide (N2O), a potent greenhouse gas.
A retrospective analysis of the women hospitalized and treated due to anemia caused by gynecological pathologies; the role of intravenous iron (ferric carboxymaltose) and blood transfusion in clinical practice.

INTRODUCTION Gynecological pathologies are an important cause of anemia in women. In this study, we aimed to evaluate women who had were hospitalized because of anemia (Hb level< 10 g/dl) caused by gynecologic pathologies and treated with either intravenous iron (ferric carboxymaltose) or blood transfusion. MATERIAL -METHOD This retrospective cross-sectional study was performed in a tertiary care center. Women who were hospitalized with the diagnosis of anemia with Hb level<10 g/dl and abnormal uterine bleeding between March 2015- September 2017 in the gynecology clinic were enrolled in the study. Hemoglobin levels, hemoglobin changes, uterine pathology and treatment of patients were recorded and compared. RESULTS One hundred and fifteen women received red blood cell transfusion and 100 women were treated with intravenous ferric carboxymaltose. The mean age of the women was 45.1 ± 6.1 (22-57) years. Although the mean Hb levels were higher in the iv iron replacement group at the end of the one month (p=0.001), the mean increase in Hb levels was similar between two treatment modalities (p=0.101). Among the anemic women who required surgery, iv iron replacement was the first choice in 75.9% of women; 34.1% received red blood cell transfusion in the preoperative period. CONCLUSIONS Gynecological pathologies are a common cause of anemia in reproductive age women and intravenous carboxymaltose treatment is a safe and cheaper alternative of blood-transfusion in appropriate cases to elevate the Hb levels in the preoperative period.
Exploration of salient risk factors involved in mild cognitive impairment

Mild cognitive impairment (MCI) is a prevalent and complex condition among older adults that often progresses into Alzheimer's disease (AD). Although MCI affects individuals differently, there are specific indicators of risk commonly associated with the development of MCI. The present study explored the prevalence of seven established MCI risk categories within a large sample of older adults with and without MCI. We explored trends across the different diagnostic groups and extracted the most salient risk factors related to MCI using partial least squares. Neuropsychological risk categories showed the largest differences across groups, with the cognitively unimpaired groups outperforming the MCI groups on all measures. Apolipoprotein E4 (ApoE4) carriers were significantly more common among the more severe MCI group, whereas ApoE4 non‐carriers were more common in the healthy controls. Participants with subjective and objective cognitive impairment were trending towards AD‐like cerebral spinal fluid (CSF) biomarker levels. Increased age, being male and having fewer years of education were identified as important risk factors of MCI. Higher CSF tau levels were correlated with ApoE4 carrier status, age and a decrease in the ability to carry out daily activities across all diagnostic groups. Amyloid beta1–42 CSF concentration was positively correlated with cognitive and memory performance and non‐ApoE4 carrier status regardless of diagnostic status. Unlike previous research, poor cardiovascular health or being female had no relation to MCI. Altogether, the results highlighted risk factors that were specific to persons with MCI, findings that will inform future research in healthy aging, MCI and AD.