Miracle-dz/UniFAR-FTUs huggingface dataset:
SIDGAN: High-Resolution Dubbed Video Generation via Shift-Invariant Learning

Dubbed video generation aims to accurately synchronize mouth movements of a given facial video with driving audio while preserving identity and scene-specific visual dynamics, such as head pose and lighting. Despite the accurate lip generation of previous approaches that adopts a pre-trained audio-video synchronization metric as an objective function, called Sync-Loss, extending it to high-resolution videos was challenging due to shift biases in the loss landscape that inhibit tandem optimization of Sync-Loss and visual quality, leading to a loss of detail.To address this issue, we introduce shift-invariant learning, which generates photo-realistic high-resolution videos with accurate Lip-Sync. Further, we employ a pyramid network with coarse-to-fine image generation to improve stability and lip syncronization. Our model outperforms state-of-the-art methods on multiple benchmark datasets, including AVSpeech, HDTF, and LRW, in terms of photo-realism, identity preservation, and Lip-Sync accuracy.
GABAergic inhibition of leg motoneurons is required for 1 normal walking behavior in freely moving Drosophila 2

GABAergic inhibition of leg motoneurons is required for 1 normal walking behavior in freely moving Drosophila 2 Swetha B.M. Gowda 1,2 , Pushkar D. Paranjpe 1 , O. Venkateswara 3 Reddy 1 ,Sudhir Palliyil 1 , Heinrich Reichert 3 , K. VijayRaghavan 1 4 5 1 National Centre for Biological Sciences, Tata Institute of Fundamental 6 Research, Bangalore 560 065, India; 7 2 Manipal University, Manipal 576 104, Karnataka, India; 8 3 Biozentrum, University of Basel, Basel 4001, Switzerland. 9 10
Management of COPD in the UK primary-care setting: an analysis of real-life prescribing patterns

Background: Despite the availability of national and international guidelines, evidence suggests that chronic obstructive pulmonary disease (COPD) treatment is not always prescribed according to recommendations. This study evaluated the current management of patients with COPD using a large UK primary-care database. Methods: This analysis used electronic patient records and patient-completed questionnaires from the Optimum Patient Care Research Database. Data on current management were analyzed by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) group and presence or absence of a concomitant asthma diagnosis, in patients with a COPD diagnosis at  35 years of age and with spirometry results supportive of the COPD diagnosis. Results: A total of 24,957 patients were analyzed, of whom 13,557 (54.3%) had moderate airflow limitation (GOLD Stage 2 COPD). The proportion of patients not receiving pharmacologic treatment for COPD was 17.0% in the total COPD population and 17.7% in the GOLD Stage 2 subset. Approximately 50% of patients in both cohorts were receiving inhaled corticosteroids (ICS), either in combination with a long-acting β 2 -agonist (LABA; 26.7% for both cohorts) or a LABA and a long-acting muscarinic antagonist (LAMA; 23.2% and 19.9%, respectively). ICS + LABA and ICS + LABA + LAMA were the most frequently used treatments in GOLD Groups A and B. Of patients without concomitant asthma, 53.7% of the total COPD population and 50.2% of the GOLD Stage 2 subset were receiving ICS. Of patients with GOLD Stage 2 COPD and no exacerbations in the previous year, 49% were prescribed ICS. A high proportion of GOLD Stage 2 COPD patients were symptomatic on their current management (36.6% with modified Medical Research Council score  2; 76.4% with COPD Assessment Test score  10). Conclusion: COPD is not treated according to GOLD and National Institute for Health and Care Excellence recommendations in the UK primary-care setting. Some patients receive no treatment despite experiencing symptoms. Among those on treatment, most receive ICS irrespective of severity of airflow limitation, asthma diagnosis, and exacerbation history. Many patients on treatment continue obese  30 kg/m 2 ; d all comorbidities defined as having a FeV 1 forced expiratory volume in second; GERD, for Chronic Obstructive Lung Disease; mMRC, modified Medical Research Council; β 2 -agonist; LAMA, long-acting muscarinic antagonist; mMRC, modified Medical Research Council; LTRA, leukotriene receptor antagonist; saMa, short-acting muscarinic antagonist; saBa, short-acting β 2 -agonist.
How to govern for sustainable tourism? An evaluation of the Dutch governance approach to sustainability

This paper evaluates the incorporation of sustainable development principles of governance in the Dutch governance structure for domestic tourism. The paper evaluates the strategies, policy instruments, actor-structures and distribution of competences for tourism development, taking as reference the 2005 joint-report of UNEP-WTO “Making Tourism More Sustainable: A Guide for Policy Makers” (2005). The main finding is that there has been a limited and only symbolic innovation of tourism governance based on sustainability principles. Further, the paper discusses the governance preferences for domestic tourism in the Netherlands, drawing on the responses to a questionnaire filled in by 44 actors across a wide range of stakeholders. The main conclusion is stakeholders’ governance preferences differ significantly. For certain actors, neo-liberal principles of governance are highly cherished and they differ from the “UNEP-WTO model”; but some still agree that voluntary policy coordination across scales and domains has added-value for sustainability. Other actors seem quite concerned with sustainability; but they do not really know if a “UNEP-WTO model” would indeed help the cause of promoting sustainable tourism development.
ERP ODOO en el proceso de venta de una PYME del Sector Gastronómico ERP ODOO in the sale process of an PYME in the Gastronomy Sector

– The following article corresponds to the implementation of the ERP ODOO in the sale process of Chifa Wang S.A. C. from the city of Trujillo, Peru. For this, a Pre-Experimental research approach is followed, where information gathering techniques such as survey and observation are used. For the implementation, the methodology proposed by VAUXOO Open source Specialist was developed, in which it specifies the following stages: Stage 1: Gap analysis, Stage 2: Supplier analysis, Stage 3: Concept and functionalities tests, Stage 4: Import of data, Stage 5: Validation and training, Stage 6: Go Live deployment, Stage 7: Second use; in which it was concluded that the development contributed to increase the quality of the sales process, which is evidenced in an improvement of 16.75% of the completion time, productivity by 16.79% of the maximum capacity of order attention per working day, a 56.52% reduction in errors made during sales; and the increase in the level of customer satisfaction in relation to the process by 30.39%. The research is described in introduction, state of the art, objectives, material and methods, methodology for the implementation of ERP ODOO, results, discussions and conclusions.
Human bony labyrinth is an indicator of population history and dispersal from Africa

The dispersal of modern humans from Africa is now well docu- mented with genetic data that track population history, as well as gene flow between populations. Phenetic skeletal data, such as cranial and pelvic morphologies, also exhibit a dispersal-from-Africa signal, which, however, tends to be blurred by the effects of local adaptation and in vivo phenotypic plasticity, and that is often deteriorated by postmortem damage to skeletal remains. These complexities raise the question of which skeletal structures most effectively track neutral population history. The cavity system of the inner ear (the so-called bony labyrinth) is a good candidate structure for such analyses. It is already fully formed by birth, which minimizes postnatal phenotypic plasticity, and it is generally well preserved in archaeological samples. Here we use morphometric data of the bony labyrinth to show that it is a surprisingly good marker of the global dispersal of modern humans from Africa. Lab- yrinthine morphology tracks genetic distances and geography in accordance with an isolation-by-distance model with dispersal from Africa. Our data further indicate that the neutral-like pattern of variation is compatible with stabilizing selection on labyrinth mor- phology. Given the increasingly important role of the petrous bone for ancient DNA recovery from archaeological specimens, we en- courage researchers to acquire 3D morphological data of the inner ear structures before any invasive sampling. Such data will consti- tute an important archive of phenotypic variation in present and past populations, and will permit individual-based genotype – phenotype comparisons.
Capacity Planning in Stable Matching

We introduce the problem of jointly increasing school capacities and finding a student-optimal assignment in the expanded market. Due to the impossibility of efficiently solving the problem with classical methods, we generalize existent mathematical programming formulations of stability constraints to our setting, most of which result in integer quadratically-constrained programs. In addition, we propose a novel mixed-integer linear programming formulation that is exponentially large on the problem size. We show that its stability constraints can be separated by exploiting the objective function, leading to an effective cutting-plane algorithm. We conclude the theoretical analysis of the problem by discussing some mechanism properties. On the computational side, we evaluate the performance of our approaches in a detailed study, and we find that our cutting-plane method outperforms our generalization of existing mixed-integer approaches. We also propose two heuristics that are effective for large instances of the problem. Finally, we use the Chilean school choice system data to demonstrate the impact of capacity planning under stability conditions. Our results show that each additional seat can benefit multiple students and that we can effectively target the assignment of previously unassigned students or improve the assignment of several students through improvement chains. These insights empower the decision-maker in tuning the matching algorithm to provide a fair application-oriented solution.
- 1-Differential protein profiling as a potential multi-marker approach for TSE diagnosis

Differential protein profiling as a potential multi -marker approach for TSE diagnosis BMC Infectious Diseases 2009, 9:188 doi:10.1186/1471-2334-9-188 Janice B Barr (janice.barr@roslin.ed.ac.uk) Michael Watson (michael.watson@bbsrc.ac.uk) Mark W Head (m.w.head@ed.ac.uk) James W Ironside (james.ironside@ed.ac.uk) Nathan Harris (nathanharr@yahoo.com) Caroline Hogarth (carolinehogarth@googlemail.com) Janet R Fraser (jan.fraser@gmail.com) Rona Barron (rona.barron@roslin.ed.ac.uk)
Spatial time domain reflectometry (Spatial TDR) – Principles, limitations and accuracy

Monitoring of transient soil moisture profiles yields valuable insight into soil hydraulic processes. A recently developed reconstruction algorithm allows deriving water content profiles along extended moisture probes from Time Domain Reflectometry (TDR) signals. Based on inverse modelling of the wave propagation along a transmission-line the algorithm calculates electrical parameter distributions. The method named Spatial TDR will be explained and the accuracy as well as the spatial and temporal resolution defining the possibilities and limitations of the procedure will be presented on practical examples.
sensory and memory stimulation as a means to care for individuals with dementia in long-term care facilities

Objective: The primary objective of this study was to identify and further examine the facilitators and barriers of utilizing sensory and memory stimulation as a means to care for individuals with dementia who live in long-term care settings. Materials and methods: The authors conducted a literature review of 30 academic articles found using the databases such as CINAHL, PubMed, and Academic Search Ultimate from the past 15 years. Facilitator and barrier themes were found within each article and analyzed for their relevance to sensory and memory stimulation therapies and their effects on individuals with dementia. Results: The most common facilitator was improved communication. The top three barriers were access, staff training, and mixed results. Discussion: Reminiscence therapy appears to provide a person-centered method of care for those who otherwise have problems communicating. These implementations will be more effective if they have the support of staff and management. Conclusion: The authors conclude that sensory and memory stimulation therapies have the potential to help improve many dementia-specific issues for individuals living in long-term care settings.
Water stress effects on growth, development, resource capture and resource use efficiency of two contrasting sugarcane genotypes.

High-fibre sugarcane may be suitable for second generation biofuel production in marginal areas. However, quantitative information about its productivity, resource use, efficiency of resource conversion and drought tolerance is lacking. This study compared growth, development and resource capture of two contrasting sugarcane genotypes under well-watered and water stress conditions. A high-sucrose sugarcane cultivar (N19) and a high-fibre sugarcane hybrid (04G0073) were planted in October 2011 at the South African Sugarcane Research Institute rainshelter facility at Mount Edgecombe, Durban, South Africa. All treatments received adequate irrigation for five months. Thereafter, irrigation was withheld from stress treatments while control treatments continued receiving adequate water. This resulted in two periods of water stress for the stress treatments of 21 and 31 days respectively, interspersed by a period of 28 days with adequate soil water brought about through an unintended intrusion of storm water. Green leaf area index (GLAI), stalk growth, radiation interception, relative available soil water content (RASWC) and midday leaf water potential (ΨL) were measured regularly. Dry aboveground biomass and its components were measured at harvest. Evapotranspiration was derived from neutron water meter measurements. Water use efficiency (WUE, defined as biomass produced per unit evapotranspiration) and radiation use efficiency (RUE, defined as biomass produced per unit radiation intercepted) were determined at harvest. Under well-watered conditions, 04G0073 grew rapidly, producing 33% more stalks at peak tillering and a higher number of green leaves per stalk, resulting in a 6% higher GLAI than N19. This enabled it to capture 3% and 5% more water and solar radiation, respectively, compared with N19. 04G0073 also converted resources more efficiently than N19 (WUE: 7.6 vs. 6.9 kg m; RUE: 1.52 vs. 1.39 gMJ) to produce a 12% higher aboveground dry biomass yield. 04G0073 partitioned significantly more stalk biomass to fibre (0.58 vs. 0.45) and significantly less to sucrose (0.24 vs. 0.36) than N19. In both genotypes, stalk elongation rates declined when RASWC dropped below 0.55. Stalk elongation of 04G0073 ceased at RASWC=0.3, compared to RASWC=0.4 for N19. Water stress reduced GLAI by 77% and 88% for N19 and 04G0073, respectively, due to decreased green leaf number (4 and 5 leaves) and decreased stalk population (18% and 6%). Water stressed 04G0073 used resources less efficiently than N19 (WUE=5.8 vs. 7.8 kg m; RUE=0.95 vs. 1.36 g MJ). This resulted in stressed 04G0073 producing significantly less (23% reduction) aboveground dry biomass than N19. Although 04G0073 used resources more efficiently to produce biomass under well-watered conditions, it was unable to tolerate severe water stress as well as N19 did. The information gathered in this study is useful for calibrating crop models for determining the feasibility of growing high-fibre cane in marginal areas.
sterile endophthalmitis rates and particle size analyses of different formulations of triamcinolone acetonide

Purpose: To evaluate the rate of sterile endophthalmitis (SE) following intravitreal injection of three different formulations of triamcinolone acetonide (TA) in a single physician practice and also to assess the mean diameter and concentration of particles of the two TA formulations currently available commercially in the USA. It was hypothesized that TA formulations with smaller particles and/or greater concentrations would have a higher incidence of SE. Methods: Single-site, interventional case series in which the medical records of 392 consecutive eyes receiving intravitreal TA as Triesence ® , Kenalog ® -40, or preservative-free TA between September 2008 and October 2013 were retrospectively reviewed for the incidence of SE. Particle sizing of TA formulations was conducted by an independent commercial laboratory. Results: Five cases of SE were identified. The four cases of SE following Triesence ® (4.6%) represented a rate significantly higher than the one case of SE following preservative-free TA (0.6%; P = 0.049) and the 0% incidence rate of SE following Kenalog ® -40 ( P = 0.0210). Triesence ® had significantly smaller particles than Kenalog ® -40 ( P , 0.0001). Conclusion: The rate of SE was the highest with the formulation of TA that had the smallest particle size and highest particle load (number of particles injected). The lowest rate of SE was seen with Kenalog ® -40, the only TA formulation that contained a benzyl alcohol preservative. The data do not support a principal causative role of benzyl alcohol in the development of TA-induced SE. Instead, the data support the particle theory of TA-induced SE; however, larger-scale, multicenter studies are needed to confirm and expand on these findings. Optometry; Pharmacology drug eye Basic eye care; Patient
Time-Delay Interferometry

Equal-arm interferometric detectors of gravitational radiation allow phase measurements many orders of magnitude below the intrinsic phase stability of the laser injecting light into their arms. This is because the noise in the laser light is common to both arms, experiencing exactly the same delay, and thus cancels when it is differenced at the photo detector. In this situation, much lower level secondary noises then set the overall performance. If, however, the two arms have different lengths (as will necessarily be the case with space-borne interferometers), the laser noise experiences different delays in the two arms and will hence not directly cancel at the detector. In order to solve this problem, a technique involving heterodyne interferometry with unequal arm lengths and independent phase-difference readouts has been proposed. It relies on properly time-shifting and linearly combining independent Doppler measurements, and for this reason it has been called Time-Delay Interferometry (TDI). This article provides an overview of the theory and mathematical foundations of TDI as it will be implemented by the forthcoming space-based interferometers such as the Laser Interferometer Space Antenna (LISA) mission. We have purposely left out from this first version of our “Living Review” article on TDI all the results of more practical and experimental nature, as well as all the aspects of TDI that the data analysts will need to account for when analyzing the LISA TDI data combinations. Our forthcoming “second edition” of this review paper will include these topics.
Topological edge and corner states in coupled wave lattices in nonlinear polariton condensates

Topological states have been widely investigated in different types of systems and lattices. In the present work, we report on topological edge states in double-wave (DW) chains, which can be described by a generalized Aubry-Andr\'e-Harper (AAH) model. For the specific system of a driven-dissipative exciton polariton system we show that in such potential chains, different types of edge states can form. For resonant optical excitation, we further find that the optical nonlinearity leads to a multistability of different edge states. This includes topologically protected edge states evolved directly from individual linear eigenstates as well as additional edge states that originate from nonlinearity-induced localization of bulk states. Extending the system into two dimensions (2D) by stacking horizontal DW chains in the vertical direction, we also create 2D multi-wave lattices. In such 2D lattices multiple Su-Schrieffer-Heeger (SSH) chains appear along the vertical direction. The combination of DW chains in the horizontal and SSH chains in the vertical direction then results in the formation of higher-order topological insulator corner states. Multistable corner states emerge in the nonlinear regime.
The G-protein-coupled estrogen receptor, a gene co-expressed with ERα in breast tumors, is regulated by estrogen-ERα signalling in ERα positive breast cancer cells

Purpose The purpose of this study was to assess the relationship between GPER, a seven transmembrane G-protein coupled estrogen receptor, and ERα in breast tumors, and to make inroads into the mechanistic basis and clinical significance. Methods TCGA-BRCA data was mined to examine the relationship between GPER and ERα expression. GPER mRNA, and protein expression were analyzed in ERα-positive or -negative breast tumors from two cohorts using immunohistochemistry, western blotting, or RT-qPCR. The Kaplan-Meier Plotter was employed for survival analysis. The influence of estrogen in vivo was studied by examining GPER expression levels in estrus or diestrus mouse mammary tissues, and the impact of 17β-estradiol (E2) administration in juvenile or adult mice. The effect of E2, or propylpyrazoletriol (PPT, an ERα agonist) stimulation on GPER expression was studied in MCF-7 and T47D cells, with or without tamoxifen or ERα knockdown. ERα-binding to the GPER locus was explored by analysing ChIP-seq data (ERP000380), in silico prediction of estrogen response elements, and chromatin immunoprecipitation assay. Results Clinical data revealed significant positive association between GPER and ERα expression in breast tumors. The median GPER expression in ERα-positive tumors was significantly higher than ERα-negative tumors. High GPER expression was significantly associated with longer overall survival of patients with ERα-positive tumors. In vivo experiments showed a positive effect of E2 on GPER expression. E2 induced GPER expression in MCF-7 and T47D cells; an effect mimicked by PPT. Tamoxifen or ERα-knockdown blocked the induction of GPER. Estrogen-mediated induction was associated with increased ERα occupancy in the upstream region of GPER. Conclusion GPER expression is positively associated with ERα in breast tumors, and a transcriptional target of the estrogen-ERα signalling axis. More in-depth studies are required to establish the significance of GPER-ERα co-expression, and their interplay in breast tumor development, progression, and treatment.
An Efficient Probe Calibration Based Near-Field-to-Near-Field Transformation for EMI Diagnosis

The near-field scanning is an effective technology for electromagnetic interference (EMI) diagnosis. An accurate and efficient near-field-to-near-field transformation in the reactive near-field region of the EMI radiation source plays an important role in the near-field scanning. In this paper, an efficient near-field-to-near-field transformation based on the electromagnetic probe calibration is proposed. By using the plane wave spectrum expansion of the probe output, the magnetic fields under test on multiplanes are obtained through a single-plane probe scanning. The proposed transformation can be considered as the extension of the prior probe compensation/calibration methods (where the field on only one plane is derived). The proposed method is validated with both numerical and experimental examples. A good agreement between the results of the proposed method and the full-wave simulation is achieved. In comparison with prior probe calibration methods, the proposed method does well, especially in determining the fields below the probe’s scanning plane. This is deterministically useful for accurately identifying the potential radiation sources during the EMI diagnosis.