Miracle-dz/UniFAR-FTUs huggingface dataset:
THE BRAIN IN HYPERTENSION

Background: Hypertension (HT) in the elderly is associated with increase occurrence rate of dementia. Purpose: We evaluated the prevalence of the pattern of high blood pressure and effects of arterial stiffness, pulse wave velocity (PWV) and wave reflections on central aortic pressure (CAP) in hypertensive patients with dementia. Methods: We analyzed a total 450 hypertensive patients with dementia, investigated using 24hr ambulatory blood pressure monitoring (ABPM). Among the HT, classified as early morning hypertension (EMHT) (early morning BP: above 135/85 mmHg and night-time BP: below 120/70 mmHg), Night HT (NHT) (Daytime BP: below 135/85 mmHg and night-time BP: above 120/70 mmHg). And using radial artery applanation tonometry, aortic pulse analysis was performed. Results: 128 patients was observed HT with stroke related dementia. EMHT was found in 55.6% of patients (n=71). Compared with patients with both EMHT and NHT, EMHT had higher aortic pulse wave velocity (PWV) and augmentation index (AI) and AI75 (AI to HR 75 beat/min), ASP (Central aortic systolic pressure) and pulse pressure were also higher in the EMHT. Conclusion: Our study showed that EMHT could have increased stroke related dementia and especial, early morning systolic BP, might be risk factor for cognitive decline. Hence active anti-hypertension treatment benefits in dementia prevention.
An Empirical Evaluation of Data Interoperability—A Case of the Disaster Management Sector in Uganda

: One of the grand challenges of disaster management is for stakeholders to be able to discover, access, integrate and analyze task-appropriate data together with their associated algorithms and work-ﬂows. Even with a growing number of initiatives to publish data in the disaster management sector using open principles, integration and reuse are still difﬁcult due to existing interoperability barriers within datasets. Several frameworks for assessing data interoperability exist but do not generate best practice solutions to existing barriers based on the assessment they use. In this study, we assess interoperability for datasets in the disaster management sector in Uganda and identify generic solutions to interoperability challenges in the context of disaster management. Semi-structured interviews and focus group discussions were used to collect qualitative data from sector stakeholders in Uganda. Data interoperability was measured to provide an understanding of interoperability in the sector. Interoperability maturity is measured using qualitative methods, while data compatibility metrics are computed from identiﬁers in the RDF-triple model. Results indicate high syntactic and technical interoperability maturity for data in the sector. On the contrary, there exists considerable semantic and legal interoperability barriers that hinder data integration and reuse in the sector. A mapping of the interoperability challenges in the disaster management sector to solutions reveals a potential to reuse established patterns for managing data interoperability. These include; the federated pattern, linked data patterns, broadcast pattern, rights and policy harmonization patterns, dissemination and awareness pattern, ontology design patterns among others. Thus a systematic approach to combining patterns is critical to managing data interoperability barriers among actors in the disaster management ecosystem.
manifested, among other things, by total neglect of personal hygiene, discontinuation of care for conditions at the place of residence, lack of seeking help from the external environment and pathological collection and withdrawal from social life

Diogenes’ syndrome is a severe, life-threatening neurobehavioral disorder. Its main symptoms are complete negligence of ones hygiene, domestic squalor, emotional and social detachment as well as pathological hoarding of unnecessary things (mostly rubbish). In most cases, it affects elderly and lonesome people. This article shows the history of said disease, starting from early mentions, then going through researches conducted by Duncan Macmillan and Patricia Shaw in 1966, up until later studies done by Clark and his colleagues this team labeled said illness in 1975 as Diogenes’ syndrome. What is more, their work covered majority of the most frequent indications along with its questionable etiopathogenesis. In addition, this article contains criteria, presented by Shehryar Khan in The American Journal of Psychiatry Residents' Journal, that can help in diagnosing this affliction. The fact that there is still very little knowledge about the therapy nor the diagnosis of Diogenes’ syndrome makes it difficult to treat. This paper describes the newest reports concerning epidemiology and the effectiveness of pharmacological treatment. The aim of that article is to gather and summarize up-to-date knowledge about said disease. Our main concern is the current, very low acquaintance with Diogenes’ syndrome which brings the challenge to the current state of medicine, especially psychiatry.
Modeling of Business Intelligence Systems using Potential Determinants and Theories

Business environments are becoming complex in the era of Industry 4.0. Therefore, enterprises need advanced innovations and technologies for quick response to the dynamic markets. [1,2]. The emergence of Business Intelligence Systems (BIS) is led by the rapid growth of technology and diffusion of the internet in the mid-90s [3,4]. BIS is generally known as a complete suite of tools, techniques, and methodologies that enable the firms to integrate and analyze large data sets in order to identify their weakness, strengths and opportunities[5–7]. BIS is an information system (IS) that facilitates decision-making by i) management ,aggregation and integration of unstructured and structured data, ii) handling with large datasets such as big data, iii) offering ad-hoc queries, reporting, forecasting, and analysis solutions, iv) end-users support with advanced processing abilities to explore new knowledge [3,8]. BIS has the ability to boost the internationalization process of organizations by sorting, summarizing, filtering and data integration from multiple channels [9], such as competitors, host markets and local government [10]. In contemporary trade, due to hyper-competition and technological advances with big data [11,12]. BI technology is still positioned among the best technological priorities of several decision-making authorities including business owners, chief executive officers (CEO) and chief information officers [3,13,14].
DEV108217 1..12

We describe the identification of zyxin as a regulator of synapse maintenance in mechanosensory neurons in C. elegans. zyx-1 mutants lacked PLM mechanosensory synapses as adult animals. However, most PLM synapses initially formed during development but were subsequently lost as the animals developed. Vertebrate zyxin regulates cytoskeletal responses to mechanical stress in culture. Our work provides in vivo evidence in support of such a role for zyxin. In particular, zyx-1mutant synaptogenesis phenotypes were suppressed by disrupting locomotion of the mutant animals, suggesting that zyx-1 protects mechanosensory synapses from locomotion-induced forces. In cultured cells, zyxin is recruited to focal adhesions and stress fibers via C-terminal LIM domains and modulates cytoskeletal organization via the N-terminal domain. The synapse-stabilizing activity was mediated by a short isoform of ZYX-1 containing only the LIM domains. Consistent with this notion, PLM synaptogenesis was independent of α-actinin and ENA-VASP, both of which bind to the N-terminal domain of zyxin. Our results demonstrate that the LIM domain moiety of zyxin functions autonomously to mediate responses to mechanical stress and provide in vivo evidence for a role of zyxin in neuronal
Can the ABCD Risk Score Predict Positive Diagnostic Testing for Emergency Department Patients Admitted for Transient Ischemic Attack?

Background and Purpose—We sought to determine if the ABCD score, typically used for risk stratification, could predict having a positive diagnostic test in patients evaluated acutely for transient ischemic attack. Methods—We performed a retrospective cohort study for patients admitted from our emergency department with a new diagnosis of transient ischemic attack confirmed by a neurologist. ABCD scores were calculated and patients with a score of 4 were placed in the high-risk cohort. Tests evaluated included electrocardiogram, CT, MRI, MR angiography, carotid ultrasonography, and echocardiography. Specific test findings considered to signify positive diagnostic tests were created a priori. Results—We identified 256 patients with transient ischemic attack for inclusion; 167 (61%) were female, the median age was 60 years (interquartile range, 50 to 72), and 162 (63%) patients had an ABCD score of 4. Rates of completion of diagnostic testing were electrocardiogram, 270 (100%); CT, 224 (88%); MRI, 89 (35%); MR angiography, 68 (27%); carotid ultrasonography, 125 (49%); and echocardiography, 135 (53%). Univariate analysis found a significant association only with elevated ABCD score and carotid duplex testing (P 0.05). Conclusion—An elevated ABCD score may help predict patients with severe carotid occlusive disease but does not predict positive outcome in other commonly ordered tests for patients being evaluated for transient ischemic attack. An elevated ABCD score cannot be recommended as a tool to guide diagnostic testing in patients presenting acutely with transient ischemic attack. (Stroke. 2009;40:3202-3205.)
JPET #90423 1 Comparison of Intravenous Buprenorphine and Methadone Self-administration by Recently Detoxified Heroin Abusers

Division on Substance Abuse, New York State Psychiatric Institute (SDC, MAS) and Department of Psychiatry, College of Physicians and Surgeons of Columbia University (SDC, MAS) 1051 Riverside Dr., Unit 120 New York, NY 10032 and Temple University School of Pharmacy (EAW) Department of Pharmaceutical Sciences 3307 North Broad Street Philadelphia, PA 19140 JPET Fast Forward. Published on September 6, 2005 as DOI:10.1124/jpet.105. 090423
OP-GTHE210200 1..12

The regulation of sleep and metabolism are highly interconnected, and dysregulation of sleep is linked to metabolic diseases that include obesity, diabetes, and heart disease. Furthermore, both acute and long-term changes in diet potently impact sleep duration and quality. To identify novel factors that modulate interactions between sleep and metabolic state, we performed a genetic screen for their roles in regulating sleep duration, starvation resistance, and starvation-dependent modulation of sleep. This screen identified a number of genes with potential roles in regulating sleep, metabolism, or both processes. One such gene encodes the auxiliary ion channel UNC79, which was implicated in both the regulation of sleep and starvation resistance. Genetic knockdown or mutation of unc79 results in flies with increased sleep duration, as well as increased starvation resistance. Previous findings have shown that unc79 is required in pacemaker for 24hours circadian rhythms. Here, we find that unc79 functions in the mushroom body, but not pacemaker neurons, to regulate sleep duration and starvation resistance. Together, these findings reveal spatially localized separable functions of unc79 in the regulation of circadian behavior, sleep, and metabolic function.
Role of Abscisic Acid in the Induction of Freezing Tolerance in Brassica napus Suspension-Cultured Cells1

Brassica napus suspension-cultured cells could be hardened in 6 days at 250C by the addition of mefluidide or ABA to the culture medium. Cells treated with mefluidide (10 milligrams per liter) or ABA (50 micromolar) attained an LTso of -17.50C or -180C, respectively, while the LT50 for the comparable nonhar- dened control (sucrose) was -10°C. The increased freezing tolerance of mefluidide-treated cells was paralleled by a 4- to 23- fold increase in ABA, as measured by gas-liquid chromatography using electron capture detection. Application of 1 milligram per liter of fluridone, an inhibitor of abscisic acid biosynthesis, pre-vented the mefluidide-induced increase in freezing tolerance and the accumulation of ABA. Both these inhibitory effects of fluridone were overridden by 50 micromolar ABA in the culture medium. On the basis of these results, we concluded that increased ABA levels are important for the induction of freezing tolerance in suspension-cultured cells.
COMPLICATIONS OF ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTIONS KOMPLIKACIJE REKONSTRUKCIJE PREDNJE UKRŠTENE VEZE

used clinical examination tests (Range of mo tion, Lachman and pivot shift) and postoperative X-rays. complication’s rate was 9% (19 patients). In patellar tendon gro up we registered one patellar fracture and pulmonary tromboembo lism and two cases of cyclops lesions. Septic arthritis was more common among professional athletes and in hamstring tendons group. Reoperations had to be performed: in 5 cases of infections (con tinous irrigation and drainage), two arthrofibrosis and one osteo synthesis of patella. Graft had to be removed in 2.5% of cases and revisions happened mostly because of impropriate position of bone tunnels and new trauma. One algodystrophic syndrome happened in hamstring tendons group. Complications were successfully treated in 12 cases but 5 patients had knee contractures, so average Knee Ostedoarthritis Outcome Scale score was 88.2 points in comparison to 93.8 points in patients without complications. Seventy-three per cent of patients returned to nonrestricted (sport) activities. Compli cations can compromise the final results of anterios cruciate ligament reconstructions. We registered similar complication rates between different grafts. Some of complications had almost every eleventh patient that resulted with reoperation at every eighteenth of them. Conclusion . The most of complications can be prevented and treated successfuly althought many questions are still left opened.
Prevalence and risk factors of antibodies to HLA according to different cut‐off values of mean fluorescence intensity in haploidentical allograft candidates: A prospective study of 3805 subjects

The importance of anti‐HLA antibodies in transplantation settings, such as HLA‐mismatched or haploidentical hematopoietic stem cell transplantation and platelet refractoriness, is widely recognized. In previous reports, it was mentioned that several cut‐off values of donor‐specific anti‐HLA antibodies mean fluorescence intensity (MFI) were related to graft rejection in the environment of HLA mismatched stem cell transplantation and the aim of this study was to investigate the prevalence and risk factors of anti‐HLA antibodies according to those cut‐off values of MFI. A total of 3805 patients with hematologic disease were prospectively enrolled and analyzed. When using MFI of anti‐HLA antibodies ≥500, ≥1000, ≥1500, ≥2000, ≥5000, and ≥ 10,000 as cut‐off values for positivity, the prevalence of class I or II anti‐HLA antibodies ranged from 4.6% to 20.2% in all cases. When the MFI cut‐off value was ≥500 for positivity, multivariate analysis indicated that platelet transfusion, underlying disease, and pregnancy were the most important risk factors for the presence of anti‐HLA antibodies for the total patients. Subgroup analysis according to age, gender, and underlying disease showed that pregnancy was the most important risk factor for the presence of anti‐HLA antibodies. For all patients (n = 3805), when anti‐HLA antibody positivity was defined according to different MFI cut‐off values, including ≥1000, ≥1500, ≥2000, ≥5000, and ≥ 10,000, an association of platelet transfusion and pregnancy with anti‐HLA antibodies was also demonstrated. Our results suggest that pregnancy and platelet transfusion are the main risk factors for the prevalence of anti‐HLA antibodies in haploid allograft candidates, providing evidence for guiding the evaluation of anti‐HLA antibodies and helping donor selection for HLA‐mismatched transplant candidates.
Desenvolvimento ponderal e biométrico de cabritos lactentes com acesso ao creep feeding em diferentes idades Performance in vivo and biometric of goatling infant with access creep feeding at different ages

SUMMARY This study aimed to evaluate the effect of the availability of creep feeding for different periods of time on weight gain, weaning weight, body condition and biometric measurements bodily crossbred goats breed Boer. 12 goats were used 7/8 Boer, nursing mothers, and their offspring, in three treatments, totaling 27 kids, nine per treatment. The experimental design was a completely randomized design with three treatments and nine replications by treatment. The treatments were: access to creep feed from birth to 70 days of age; access to creep feed from 20 days until 70 days of age; access to creep feed from 40 days until 70 days of age. Data were collected every 10 days. The analysis of variance and comparison of means was performed by Tukey test. The different treatments possible differences in weight gain, body weight, body length, heart girth and abdominal and hip height. There was no difference in body condition and withers height and animals. The best results were observed in groups subjected to higher access times supplementation. Thus, we indicate this type of supplementation during breastfeeding for at least 50 days, and demonstrate the irrelevance of supply concentrated in the first 20 days of life. Keywords : goats, growth, measures, supplementation
Opiniones de los adolescentes escolares sobre consumo de drogas: un estudio de caso en Lima, Perú

El consumo de drogas ha aumentado en todas las regiones del mundo, volviendose un problema desalud publica, afectando especialmente a los adolescentes. Este estudio tiene como objetivos identificar lasopiniones de los adolescentes escolares sobre el uso de drogas e identificar la opinion sobre el consumidor dedrogas, en un colegio de Lima-Peru. Estudio descriptivo y transversal, se uso un cuestionario autoaplicado a386 estudiantes. Se obtuvo datos personales del escolar, la percepcion de riesgo del consumo de drogas,motivaciones, informacion acerca de medidas preventivas, disponibilidad de la droga, la opinion sobre elconsumidor de drogas e la aceptacion social y familiar al consumidor de drogas. Predomina el sexo masculinoen las caracteristicas personales. Al opinar sobre la percepcion de riesgo la mayoria tiene opinion desfavorablede los motivos de consumo y esta a favor de la informacion. Tenemos un relevante papel tanto para explicarlas conductas como para la puesta en practica de programas adecuados y eficaces de prevencion y tratamiento.DESCRIPTORES: adolescente; drogas ilicitas; transtornos relacionados ao uso de substâncias
Milk and Egg Are Risk Factors for Adverse Effects of Capecitabine-Based Chemotherapy in Chinese Colorectal Cancer Patients

Background: Chemotherapy-induced adverse effects (CIAEs) remain a challenging problem due to their high incidences and negative impacts on treatment in Chinese colorectal cancer (CRC) patients. We aimed to identify risk factors and predictive markers for CIAEs using food/nutrition data in CRC patients receiving post-operative capecitabine-based chemotherapy. Methods: Food/nutrition data from 130 Chinese CRC patients were analyzed. Univariate and multivariate analyses were used to identify CIAE-related food/nutrition factors. Prediction models were constructed based on the combination of these factors. The area under the receiver operating characteristic curve (AUROC) was used to evaluate the discrimination ability of models. Results: A total of 20 food/nutrition factors associated with CIAEs were identified in the univariate analysis after adjustments for total energy and potential confounding factors. Based on multivariate analysis, we found that, among these factors, dessert, eggs, poultry, and milk were associated with several CIAEs. Most importantly, poultry was an overall protective factor; milk and egg were risk factors for hand-foot syndrome (HFS) and bone marrow suppression (BMS), respectively. Developed multivariate models in predicting grade 1 to 3 CIAEs and grade 2/3 CIAEs both had good discrimination (AUROC values from 0.671 to 0.778, 0.750 to 0.946 respectively), which had potential clinical application value in the early prediction of CIAEs, especially for more severe CIAEs. Conclusions: Our findings suggest that patients with high milk and egg intakes should be clinically instructed to control their corresponding dietary intake to reduce the likelihood of developing HFS and BMS during capecitabine-based chemotherapy, respectively. Trial registration: ClinicalTrials.gov Identifier: NCT03030508.
[Effect of γδ T cells on the Proliferation, Apoptosis and Autophagy of Multiple Myeloma Cells].

AbstractObjective: To investigate the effect of γδ T cells on the proliferation, apoptosis and autophagy of multiple myeloma cells. METHODS Peripheral blood mononuclear cells (PBMNC) were isolated from healthy volunteers, and stimulated with zoledronic acid (Zol) in combination with rhIL-2. Flow cytometry analysis was used to detected the purity of γδ T cells. γδ T cells were collected and co-cultured with RPMI-8226 or U-266 cells at different effector target ratios. The proliferation of RPMI-8226 or U-266 cell lines were detected by CCK-8. Cell cycle and cell apoptosis were detected by flow cytometry and Western blot．The expressions of autophagy-related proteins were detected by Western blot. RESULTS γδ T cells can be expanded in vitro. γδ T cells could inhibit the proliferation of RPMI-8226 or U-266 cells, induced cell cycle arrest and promoted apoptosis in an effector target-dependent manner. In addition, γδ T cells could induce autophagy of myeloma cells, inhibited the expression of autophagy-related PI3K, P-AKT and P-mTOR, while increased the expression of AMPK and Beclin-1. CONCLUSION γδ T cells can inhibit the proliferation of RPMI-8226 and U-266 myeloma cells, induce cell cycle arrest, promote apoptosis, and enhance autophagy in vitro. The mechanism may be related to inhibition of PI3K/AKT/mTOR signaling pathway and/or activation of AMPK/Beclin-1 signaling pathway.
Favorable Transverse Maxillary Development after Covering the Lateral Raw Surfaces with Buccal Fat Flaps in Modified Furlow Palatoplasty: A Three-Dimensional Imaging–Assisted Long-Term Comparative Outcome Study

Background: The pedicled buccal fat flap has recently been applied to cover the lateral raw surfaces during palatoplasty as an attempt to mitigate scar-induced transverse maxillary constriction during growth, but with no formal long-term comparative analysis. This three-dimensional imaging–assisted study assessed its impact on posterior transverse maxillary development. Methods: Cone beam computed tomographic scans from patients with unilateral cleft lip, alveolus, and palate who received buccal fat flap (buccal fat group; n = 22) or Surgicel (Surgicel group; n = 32) for covering lateral raw surfaces during modified Furlow palatoplasty at 9 to 10 months of age and had reached the age of 9 years were retrieved for analysis. Patients with unilateral cleft lip and alveolus (nonpalatoplasty group; n = 24) were also included for comparison. Using three-dimensional maxillary image models, linear (U6T-MSP and U6J-MSP) and area measurements were calculated for cleft and noncleft posterior maxillary sides and for total posterior transverse maxillary dimension. Results: The buccal fat group had significantly (all p < 0.05) wider dimensions compared with the Surgicel group for all transverse maxillary measurements on both the cleft and noncleft sides, except for U6J-MSP and posterior palatal area parameters on the cleft side (p > 0.05). The buccal fat group had significantly (all p < 0.05) wider total transverse maxillary dimensions compared with the Surgicel and nonpalatoplasty groups. Conclusion: Covering the lateral raw surfaces with buccal fat flaps resulted in less posterior transverse maxillary constriction compared with the Surgicel-based covering procedure. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.