Miracle-dz/UniFAR-FTUs huggingface dataset:
Inflammation in Prostate Cancer: Exploring the Promising Role of Phenolic Compounds as an Innovative Therapeutic Approach

Prostate cancer (PCa) remains a significant global health concern, being a major cause of cancer morbidity and mortality worldwide. Furthermore, profound understanding of the disease is needed. Prostate inflammation caused by external or genetic factors is a central player in prostate carcinogenesis. However, the mechanisms underlying inflammation-driven PCa remain poorly understood. This review dissects the diagnosis methods for PCa and the pathophysiological mechanisms underlying the disease, clarifying the dynamic interplay between inflammation and leukocytes in promoting tumour development and spread. It provides updates on recent advances in elucidating and treating prostate carcinogenesis, and opens new insights for the use of bioactive compounds in PCa. Polyphenols, with their noteworthy antioxidant and anti-inflammatory properties, along with their synergistic potential when combined with conventional treatments, offer promising prospects for innovative therapeutic strategies. Evidence from the use of polyphenols and polyphenol-based nanoparticles in PCa revealed their positive effects in controlling tumour growth, proliferation, and metastasis. By consolidating the diverse features of PCa research, this review aims to contribute to increased understanding of the disease and stimulate further research into the role of polyphenols and polyphenol-based nanoparticles in its management.
The influence of field environmental conditions on the growth and development of four cauliflower cultivars

To develop a technique for predicting the time of crop maturity, the influences of temperature and solar radiation on the growth and development of a sequence of transplantings of four summer-autumn cauliflower cultivars were studied on two sites in 1986 and 1987. The minimum number of leaves formed before curd initiation was 21 to 22 in all four cultivars . The maximum numbers of leaves before the curd were 38,42,47 and 50 in cvs White Fox, Dok Elgon, White Rock and Revito, respectively. The wide variation in the number of leaves to curd initiation indicates the sensitivity of curd initiation to environmental conditions. Variation in the duration of curd growth was much less than that of the period from transplanting to curd initiation when expressed both as days and accumulated day- degrees. A single quadratic curve for all cultivars relating the time from transplanting to maturity to the date of transplanting, accounted for only 27.8% of the variance of the time from transplanting to maturity. Parallel.
The Investigation of an Accident Site With an Atypical Electrocution Exit Wound and Burn in an Unusual Location: A Rare Case Report and Review of Literature

Cases involving electrocution burns are tough to investigate for the clinical forensic practitioner. Burns from high-voltage electrocution might seem like burns from other sources, especially if the victim is in an unconscious state. In this situation, circumstantial evidence in addition to clinical symptoms may be used to exclude other burns. Furthermore, the investigation of accident site results to aid in explaining the pattern of injuries discovered during a clinical evaluation. In this case study, we reported a case of a 33-year-old male who came in contact with a high-voltage transmission wire and was burned over both hands and lower back region. The exit wound was atypical in appearance, with a scorched area of peeling blistering skin, charring, and severe scorching over the lower back region which were correlated with the accident site, and the circumstances that led to electrocution injury.
How Refined Surgical Technical Solutions Can Make Bentall Operation a Low-Risk Procedure: 20-Year Personal Experience at the “Root” of the Aortic Diseases—It Is Time to Change Surgical Guidelines

(1) Objective: Twenty years’ experience of Bentall–De Bono operations by one surgeon. (2) Methods: From January 2003 to September 2023, four-hundred-and-two patients aged 65.9 ± 15 years underwent a Bentall operation. The EuroScore-2 was 5.0% ± 3.8%. Associated procedures were performed on 113 patients (28.1%). Results: Operative mortality was 1.2% (n = 5), in particular 0.69% (n = 2/289) for isolated Bentall operation, 2.65% (n = 3/113) for combined procedures (p < 0.05). Postoperative acute heart failure occurred in 38 patients (9.45%). Preoperative pulmonary hypertension (44 ± 14 vs. 33 ± 7 mmHg), cardiopulmonary bypass time (169 ± 61 min. vs. 124 ± 42 min.) and aortic cross-clamp time (133 ± 45 min. vs. 107 ± 34 min.) have been recognized as independent predictors of mortality and cardiac complications (p < 0.05). Conclusions: In our experience, the Bentall operation was associated with low operative mortality and low rate of complications. For this reason, in agreement with the patients, we have modified surgical indication for ascending aortic aneurysms and now we think that it is time to change surgical guidelines.
Diversity and Functional Potential of Prokaryotic Communities in Depth Profile of Boreo-Nemoral Minerotrophic Pine Swamp (European Russia)

Natural peatlands represent a wide range of habitats that contribute to the conservation of biodiversity, including microbial biodiversity. Molecular biological methods make it possible to significantly increase the accounting of microbial diversity compared to the cultivation methods. The studies on microbial diversity in minerotrophic peatlands using molecular biological methods lag significantly behind such studies for ombrotrophic peatlands. In this work, we characterized the taxonomic composition and functional potential of the prokaryotic community of the minerotrophic pine swamp (fen) in the Tver region of northwestern Russia using high-throughput sequencing of 16S rRNA gene fragments. This study is unique, since it was carried out not in individual horizons but across the entire fen profile, taking into account the differentiation of the profile into the acrotelm and catotelm. The composition and dominants of bacterial and archaeal communities were determined not only at the level of phyla but also at the level of classes, families, and cultivated genera. The prokaryotic community of the studied fen was shown to have a high taxonomic diversity (28 bacterial and 10 archaeal phyla were identified). The profile differentiation of the taxonomic composition of prokaryotic communities is most clearly manifested in the analysis of the acrotelm and catotelm. In the bacterial communities of the acrotelm, the top three phyla included Acidobacteriota, Alphaproteobacteria, and Actinomycetota, in the catotelm—Betaproteobacteria, Bacteroidota, and Chloroflexota. In archaeal communities of the acrotelm, we discovered the monodominance of Nitrososphaerota, in the catotelm—the dominance of Bathyarchaeota and subdominance of Thermoplasmatota, Halobacterota, and Aenigmarchaeota. The hot spots of microbial diversity in the studied fen profile were found to be the 0–20 cm layer of the acrotelm and the 150–200 cm layer of the catotelm. In contrast to the taxonomic composition, the functional profiles of the prokaryotic communities of the acrotelm and catotelm were generally similar, except for methane metabolism, which was primarily carried out in the catotelm.
Determination of the Aptamer Probe Density by Double Layer and Redox Capacitance of CNT-Based Electrochemical DNA-Aptasensors

Electrochemical DNA-Aptasensors are gaining increasing popularity for the recognition of numerous analytes ranging from tiny molecules to entire microorganisms due to their multiple benefits over antibody-based biosensors. However, the reliable determination of aptamer probe density in DNA-Aptasensors is a potential barrier to ensuring their quality and performance. In this regard, an innovative, simple, and reliable electrochemical method has been introduced by exploring the redox capacitance (CR) using [Ru(NH3)6]3+/2+as a model redox species to determine the DNA-Aptamer probe density on a CNT (carbon nanotube) modified gc (glassy carbon) electrode surface. Moreover, the results were compared with the probe density calculated by the existing method using double layer capacitance (CD). Despite a lack of reproducibility caused by the non-specifically adsorbed aptamers on CNT, an excellent coincidence was found between the results obtained following those two methods. Therefore, the new method will accelerate the commercialization of electrochemical DNA-Aptasensors by confirming their quality through assessing the reliable DNA-Aptamer probe density.
A general-purpose organic gel computer that learns by itself

To build energy minimized superstructures, self-assembling molecules explore astronomical options, colliding ∼109 molecules s−1. Thus far, no computer has used it fully to optimize choices and execute advanced computational theories only by synthesizing supramolecules. To realize it, first, we remotely re-wrote the problem in a language that supramolecular synthesis comprehends. Then, all-chemical neural network synthesizes one helical nanowire for one periodic event. These nanowires self-assemble into gel fibers mapping intricate relations between periodic events in any-data-type, the output is read instantly from optical hologram. Problem-wise, self-assembling layers or neural network depth is optimized to chemically simulate theories discovering invariants for learning. Subsequently, synthesis alone solves classification, feature learning problems instantly with single shot training. Reusable gel begins general-purpose computing that would chemically invent suitable models for problem-specific unsupervised learning. Irrespective of complexity, keeping fixed computing time and power, gel promises a toxic-hardware-free world. One sentence summary: fractally coupled deep learning networks revisits Rosenblatt’s 1950s theorem on deep learning network.
A mechanical‐optical method of reduction of pairs of auroral plates

(1) In this paper a new method is suggested for the reduction of the great number of pairs of auroral plates that have accumulated during the Polar Year, and will continue to be obtained in future. The existing methods of determining the height and geographical situation of the aurorae require plate-measurement and mathematical calculation. There should, it would seem, be some mechanical-optical method which, despite a possibly considerable initial cost for the equipment needed, would in the long run save much time, labor, and money. The impulse to think out such a method came from suggestions made to me by Dr. la Cour, at Brussels in July 1934 and, more effectively, at London in September 1934.
Residents Coping Strategies with Water Scarcity in Makurdi Town, Nigeria

This paper examines the degree of water scarcity across Makurdi town as well as the strategies employed by residents to cope with the problem. Data was gathered via questionnaire administered to 228 respondents mainly household heads (both male and female) who were randomly selected. The results reveal that total household water demand in Makurdi town is estimated at 127,600 lpd more than the actual available supply of 40,520 lpd leading to shortfalls of about 87,080 lpd. This translates to about 68.2% of water demand not satisfied by supply. Findings also show that the major coping strategies employed by residents include: dredging dry hand-dug wells to get water (30.2%), storing water in big containers (26.3%) and walking long distances to get water (18.9%). The Fisher’s Exact (�( �y�I�‘�÷�A �; statistic was employed to test for association between some sociodemographic variables and the coping strategies adopted by residents. The results reveal no association between level of education and the strategies adopted by residents. The results however shows association between level of income, place of residence and the coping strategies adopted. The Likert scaling was used to investigate the causes of water scarcity in the study area. The failure of public water supply system is widely perceived as the major cause of water scarcity in Makurdi town. The paper recommends that residents should be encouraged to pool resources together to provide water supply projects for their common use.
An integrated and open source GIS environmental management system for a protected area in the south of Portugal

Herdade da Contenda (HC), located in Moura municipality, Beja district (Alentejo province) in the south of Portugal (southwestern Iberia Peninsula), is a national hunting area with 5270ha. The development of an integrated system that aims to make the management of the natural and cultural heritage resources will be very useful for an effective management of this area. This integrated system should include the physical characterization of the territory, natural conservation, land use and land management themes, as well the cultural heritage resources. This paper presents a new tool for an integrated environmental management system of the HC, which aims to produce maps under a GIS open source environment (QGIS). The application is composed by a single button which opens a window. The window is composed by twelve menus (File, DRASTIC, Forest Fire Risk, Revised Universal Soil Loss Equation (RUSLE), Bioclimatic Index, Cultural Heritage, Fauna and Flora, Ortofoto, Normalizes Difference Vegetation Index (NDVI), Digital Elevation Model (DEM), Land Use Land Cover Cover (LULC) and Help. Several inputs are requires to generate these maps, e.g. DEM, geologic information, soil map, hydraulic conductivity information, LULC map, vulnerability and economic information, NDVI. Six buttons were added to the toolbar which allows to manipulate the information in the map canvas: Zoom in, Zoom out, Pan, Print/Layout and Clear. This integrated and open source GIS environment management system was developed for the HC area, but could be easily adapted to other natural or protected area. Despite the lack of data, the methodology presented fulfills the objectives.
Progress and Strategy of the Improvement of Indica Rice Varieties in the Yangtse Valley of China

The data of national rice regional trial in southern China from 1986 to 2002 were analyzed. Obvious progress has been achieved in improvement of indica rice varieties in the Yangtse Valley during the last seven years(1996-2002). The average yield increased by more than 12% and grain quality was improved significantly, but resistance to main pests was not improved obviously compared to those during “the 7th Five year Plan”(1986-1990) and“ the 8th Five year Plan”(1991-1995). Proper heightening plant would play an important role indirectly to increase yield. Based on suitable number of effective panicles and grain weight, it was very important to increase grains per panicle to improve both the yield and grain quality. Strategies were proposed for raising the breeding level further.
Site Factors Related to Dry Farm Vegetable Productivity and Quality in the Willamette Valley of Oregon

Dry farming has been defined as rainfed crop production in a climate with more than 20 inches of annual precipitation, but where most precipitation falls outside the growing season. Dry farming is garnering interest in the western United States because it allows farmers to produce crops despite a lack of access to irrigation or water rights or to eliminate the infrastructure, labor, and energy costs of irrigation systems. Sites have differing suitability for dry farming, and some sites that can be farmed with irrigation will perform poorly when dry-farmed. To determine site factors associated with dry farm yield and fruit quality, trials of ‘Early Girl’ tomato (Solanum lycopersicum) and ‘North Georgia Candy Roaster’ winter squash (Cucurbita maxima) were conducted at 17 participant farms in the Willamette Valley in Oregon, USA, in 2018 and 2019. The mean blossom-end rot (BER) incidence was higher in the Willamette Valley than in coastal California; this was probably because of the Willamette Valley’s hotter and drier climate. Increasing the available water-holding capacity of soil, total available water (available water-holding capacity of the soil plus in-season rainfall), native productivity rating, soil pH (0–6 inches and 24–36 inches), soil nutrient concentrations (0–6 inches and 24–36 inches), and in-season rainfall were positively associated with at least one measure of tomato or winter squash yield, fruit number, or average fruit weight. An earlier planting date was positively associated with winter squash total yield and total fruit number in 2019. The water-limited yield potential (the total yield potential if water was the only limiting factor) for 20-ft2/plant plots was estimated to be 2.2 tons/acre per inch for tomato and 2.8 tons/acre per inch for winter squash. In 2019, high-density plantings (20 ft2/plant) had higher tomato and winter squash mean total yields, mean total fruit numbers, and mean tomato unblemished yield than low-density plantings (40 ft2/plant). In 2019, planting tomato at 20 ft2/plant decreased the mean BER incidence by 15.6% when compared with planting tomato at 40 ft2/plant.
Animal and Plant Health Inspection Service 2013 Patterns of Human – Coyote Conflicts in the Denver Metropolitan Area

In many cities throughout North America, human–coyote conflicts are an emerging problem. Little research has described temporal and spatial patterns of human–coyote conflicts, although such information can be an important step in developing and optimizing management efforts. We used reports from 22 entities within the Denver Metropolitan Area (DMA) in Colorado that provided information on coyote observations (signs, sightings, and encounters) and conflicts (incidents, pet-attacks, and humanattacks). Our objectives were to 1) define, quantify, and map categories of coyote observations and conflicts, and 2) investigate temporal and spatial patterns of conflicts, particularly related to land cover types and housing density classes. We compiled 4,006 coyote reports, including 78 signs (1.9%), 3,023 sightings (75.5%), 395 encounters (9.9%), 26 incidents (0.6%), 471 pet-attacks (11.8%), and 13 human-attacks (0.3%). We found a strong seasonal pattern with reports of both observations and conflicts highest duringDecember– March and lowest during July–September. Numbers of coyote conflicts were disproportionately greater in open space and development land cover types (in contrast to natural and agricultural land cover) and in suburban housing areas (in contrast to urban, exurban, and rural areas). Hotspots of coyote conflicts were apparent in the southern region of the DMA, possibly because coyotes had better access to development, and hence interaction with residents, via natural areas bordering urban areas; reporting bias may have also influenced this outcome. Our results will help target management efforts, particularly those focused on people (e.g., education), but also highlight the critical need for improved methods of collecting conflict information via a standardized reporting mechanism to help reduce bias. 2012 The Wildlife Society.
The Character and the Mechanism of the Vegetation Development in Sanjiang Plain in the Past Fifty Years

With the prosperity of population and economy,the ecosystem has been changed greatly in Sanjiang plain in the past fifty years,especially the transformation of the vegetation is more evident.These transformations have aroused the people's more attention about the ecosystem of Sanjiang plain.The text analyses the basic reason of the formation about the nature vegetation under the especial climate,water and geography,and analyses the distributing pattern of the nature vegetation according to the terrain and hypsography;the text also introduces respectively the characteristics and transformation of distributing,species structure and existing circumstance in the past fifty years about three nature vegetations: model swamp wetland,the forest and the meadow.The basic driving force is explained from nature and artificiality,and the basic transformation mechanism of the model wetland vegetation under the human influence is set forth.
Biddy Ball: A New Way to Run Introductory Basketball

Abstract For far too long, recreational programs have put too much emphasis on a traditional model that is not effective for player development and sadly does not allow players to have fun while learning the fundamentals of a sport. A great solution to this problem that encourages five- to seven-year-olds is an approach called Biddy Ball. This article explores the problems with the traditional approach and then gives an overview of the basics and key features of Biddy Ball. Emphasis is placed on young players being provided with opportunities to learn basic skills in a fun, engaging environment.
Phase equilibria constraints on the melt fertility of crustal rocks: the effect of subsolidus water loss

During regional prograde metamorphism, H2O generated by ongoing dehydration reactions is likely to be continuously lost from a rock by compaction. Classical melting experiments cannot easily simulate this phenomenon, because ideally, all run products are conserved within the experimental charge, although significant equilibration and H2O generation may occur during heating. Phase equilibria modelling is used to consider the effect of subsolidus water loss (SWL) on subsequent melting relationships of felsic lithologies (including metapelite, metagreywacke and metatonalite) in the suprasolidus. SWL drives the bulk composition towards the minimum saturation point on the boundary of the wet‐melting field and results in significantly reduced subsequent melt generation when compared to melting experiments involving conservation of subsolidus H2O. This effect is most significant at P–T conditions just above the solidus. For initially hydrated rocks, the reduction in melt production causes rheologically critical thresholds (e.g. melt connectivity threshold, melt escape threshold and the solid‐to‐liquid transition) to be intersected at temperatures generally more than 100 °C, higher than predicted by idealized experimental melting curves.
Evaluation of network system of hydrological stations of Yangtze River Basin and proposals for its development

According to the mass screening of network of hydrological stations of Yangtze River Basin,the network system of the hydrological stations was analyzed and evaluated for the first time.Through an overall,in-depth and systematic analysis and evaluation of the network of hydrological stations in the aspects of the development history,density and distribution,function and aim evaluation and so on,the status of the network was made clear.The achievements,as well as the problems and difficulties of the plan and construction of the network were summarized.On this basis,scientific advices to the plan and development of the network of hydrological stations of Yangtze River Basin were proposed.