Miracle-dz/UniFAR-FTUs huggingface dataset:
A critical period for experience-dependent development of the feelings of safety during early infancy: A polyvagal perspective on anger and psychometric tools to assess perceived safety

COPYRIGHT © 2022 Poli, Gemignani, Chiorri and Miccoli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. A critical period for experience-dependent development of the feelings of safety during early infancy: A polyvagal perspective on anger and psychometric tools to assess perceived safety
An Approach to Ripening of Pineapple Fruit with Model Yolo v5

In the Fourth Industrial Revolution, Artificial Intelligence is being widely applied in society to improve the quality of life. Advanced technology is applied to industrialized and modernized models to improve the quality and increase the accuracy of production models. In the current agricultural model, humans are used as the main workforce, which is costly in terms of finance as well as human resources. The typical fruits of each region, especially pineapple, have a rather complicated ripening period. It is difficult to control and manage hundreds of hectares of fields. Therefore, in this paper, we propose to use deep learning models to assist in identifying and detecting the ripening period of pineapples to ensure that the care and harvest is carried out on time. Our best accuracy is observed over 95%.
Genetics of adaptation

The rediscovery of Mendel’s work showing that the heredity of phenotypes is controlled by discrete genes was followed by the reconciliation of Mendelian genetics with evolution by natural selection in the middle of the last century with the Modern Synthesis. In the past two decades, dramatic advances in genomic methods have facilitated the identification of the loci, genes, and even individual mutations that underlie phenotypic variants that are the putative targets of natural selection. Moreover, these methods have also changed how we can study adaptation by flipping the problem around, allowing us to first examine what loci show evidence of having been under selection, and then connecting these genetic variants to phenotypic variation. As a result, we now have an expanding list of actual genetic changes that underlie potentially adaptive phenotypic variation. Here, we synthesize how considering the effects of these adaptive loci in the context of cellular environments, genomes, organisms, and populations has provided new insights to the genetic architecture of adaptation.
On a scale invariant model of statistical mechanics and the kinetic theory of ideal gas

A scale invariant model of statistical mechanics is applied to derive invariant Maxwell-Boltzmann speed and Planck energy spectrum of equilibrium statistical fields including that of isotropic stationary turbulence. The latter is shown to lead to the definitions of (electron, photon, neutrino) respectively as theggg most-probable equilibrium sizes of (photon, neutrino, tachyon) clusters. Also, invariant modified form of the first law of thermodynamics is derived and a modified definition of entropy, invariant forms of transport coefficients, and hierarchies of absolute zero temperatures and vacua are described. The physical basis for the coincidence of normalized spacings between zeros of Riemann zeta function and the normalized Maxwell-Boltzmann distribution and its connections to Riemann Hypothesis are examined. New paradigms for hydrodynamic foundations of both Schrodinger as well as Dirac wave equations are discussed.
Metal–Organic Frameworks for Electrocatalytic Sensing of Hydrogen Peroxide

The electrochemical detection of hydrogen peroxide (H2O2) has become more and more important in industrial production, daily life, biological process, green energy chemistry, and other fields (especially for the detection of low concentration of H2O2). Metal organic frameworks (MOFs) are promising candidates to replace the established H2O2 sensors based on precious metals or enzymes. This review summarizes recent advances in MOF-based H2O2 electrochemical sensors, including conductive MOFs, MOFs with chemical modifications, MOFs-composites, and MOF derivatives. Finally, the challenges and prospects for the optimization and design of H2O2 electrochemical sensors with ultra-low detection limit and long-life are presented.
Exploring public perceptions and attitudes on palm oil

Palm oil has become one of the leading causes of deforestation in countries that are developing their economic growth. Despite the vast research and knowledge of the advantages and disadvantages of palm oil, little is known about how people perceive this information and where they would like to obtain information. Our results indicate that there is a general lack of awareness and knowledge about palm oil and the issues surrounding it. Whilst education has played an important role in providing information, the most sought after channel is the internet and social media.
Elastic Slab in Viscoelastic Mantle: Effects on Determining Megathrust Slip and Mantle Viscosity During Postseismic and Interseismic Phases

Earthquake‐cycle deformation at subduction zones is not only induced by cyclical faulting processes but also impacted by the Earth structure and rheology. Oversimplifying the first‐order Earth structure in models leads to biased estimations of fault kinematics and Earth rheology and hence misinterpretation of subduction‐zone dynamics. Here we first use synthetic models to investigate the impacts of an elastic slab on viscoelastic postseismic and interseismic deformation and on determining afterslip, locking distribution, and mantle viscosity. We confirm that the presence of a slab causes anchored viscous flow in the mantle wedge and less extensive viscoelastic deformation in the overriding plate than the depth‐dependent layered models without a slab during the interseismic and postseismic phases. By assuming the predicted viscoelastic deformation from the model with a slab as the synthetic true observations, layered models obtain a higher viscosity and more slip on the downdip of the seismogenic zone than the true model during both phases. These biased estimates are found varying with the displacement component, spatial and temporal coverages of the used observations. We then conduct two real‐world case studies at the Japan subduction zone and find that the layered model obtains the biased fault kinematics and mantle viscosity that are similar to the synthetic modeling results, indicating that the slab signature may have been observed in the geodetic data. Our findings highlight the importance of including a slab in modeling the earthquake‐cycle deformation and thoroughly exploring the sensitivities of surface deformation, especially the verticals, on the deep Earth structures.
Decision of Anticoagulation in Nonvalvular Atrial Fibrillation in the Real World in the Non-Antivitamin K Anticoagulants Era

Background. Patients with nonvalvular atrial fibrillation (NVAF) have five times higher risk of stroke than the general population. Anticoagulation (ACO) in NVAF is a class I indication after assessing the CHA2DS2-VASc and HAS-BLED scores. However, in the real world, NVAF patients receive less ACO than needed due to patients’ comorbidities that can be assessed by the Charlson comorbidity index (CCI). The use of non-antivitamin K anticoagulants (NOAC) has improved the decision to anticoagulate. Objective. We analyzed the factors influencing the ACO prescribing decision in NVAF patients in the real world and the changes induced by the introduction of NOAC. Method. We carried out an observational retrospective cross-sectional study that included consecutive patients with permanent NVAF and CHA2DS2-VASc ≥ 2, admitted to a community hospital between 2010–2011 (group 1, 286 patients), when only vitamin K antagonists (VKA) were used, and 2018–2019 (group 2, 433 patients), respectively. We calculated CHA2DS2-VASc, HAS-BLED, and CCI and recorded the ACO decision and the use of VKA or NOAC in group 2. We compared the calculated scores between ACO and non-anticoagulated (nonACO) patients in both groups and between groups. Results. A 31.5% share of patients in group 1 and 12.9% in group 2 did not receive ACO despite a CHA2DS2-VASc score ≥ 2. In group 1, nonACO patients had higher HAS-BLED and CCI scores than the ACO patients, but their CHA2DS2-VASc scores were not significantly different. Old age, dementia, severe chronic kidney disease, neoplasia, and anemia were the most frequent reasons not to prescribe anticoagulants. In group 2, more nonACO patients had dementia, diabetes mellitus, and higher HAS-BLED than ACO patients. Moderate-severe CKD, neoplasia with metastasis, liver disease, anemia, and diabetes mellitus were statistically significantly more frequent in nonACO patients from group 1 than those from group 2. In group 2, 55.7% of ACO patients received NOAC. Conclusions. In real-world clinical practice, the decision for anticoagulation in NVAF is influenced by patient age, comorbidities, and risk of bleeding, and many patients do not receive anticoagulants despite a high CHA2DS2-VASc score. The use of NOAC in the past few years has improved treatment decisions. At the same time, the correct diagnosis, treatment, and surveillance of comorbidities have cut down the risk of bleeding and allowed anticoagulant use according to guidelines.
Consumers’ Cooperation with Sustainability Programs: The Role of Luxury Branding and Profit Motive Attribution

In this research, we investigate consumers’ willingness to cooperate with luxury versus non-luxury hotels’ environmental protection programs. We find that while consumers’ cooperation with non-luxury hotels becomes less favorable when consumers perceive the sustainability program to have a profit motive, consumers’ cooperation with luxury hotels remains high even when consumers perceive the hotel’s sustainability program to be profit-driven. We find a similar pattern for customer loyalty. In addition, we find that this interactive effect emerges when affective attitudes toward luxury brands are strong. These results contribute to the literature by identifying a condition where profit motive attribution does not hurt consumer conservation intentions and by revealing a condition where luxury brands may benefit from sustainability programs. We discuss theoretical and practical implications as well as directions for future research.
Programmable Polyproteams of Tyrosine Ammonia Lyases as Cross-Linked Enzymes for Synthesizing p-Coumaric Acid

Ideal immobilization with enhanced biocatalyst activity and thermostability enables natural enzymes to serve as a powerful tool to yield synthetically useful chemicals in industry. Such an enzymatic method strategy becomes easier and more convenient with the use of genetic and protein engineering. Here, we developed a covalent programmable polyproteam of tyrosine ammonia lyases (TAL-CLEs) by fusing SpyTag and SpyCatcher peptides into the N-terminal and C-terminal of the TAL, respectively. The resulting circular enzymes were clear after the spontaneous isopeptide bonds formed between the SpyTag and SpyCatcher. Furthermore, the catalytic performance of the TAL-CLEs was measured via a synthesis sample of p-Coumaric acid. Our TAL-CLEs showed excellent catalytic efficiency, with 98.31 ± 1.14% yield of the target product—which is 4.15 ± 0.08 times higher than that of traditional glutaraldehyde-mediated enzyme aggregates. They also showed over four times as much enzyme-activity as wild-type TAL does and demonstrated good reusability, and so may become a good candidate for industrial enzymes.
Certificação Sexism Free Night: da visibilização do assédio sexual à criação de um roteiro de lazer noturno mais seguro e igualitário no Porto

Sexism Free Night Label: Making sexual harassment visible in order to create safer and more egalitarian nightlife environments in Oporto This paper presents a gender analysis of sexual harassment in nightlife environments based on bystanders’ perceptions and the evaluation of the implementation of the Sexism * Centro de Investigação para o Desenvolvimento Humano (CEDH), Faculdade de Educação e Psicologia da Universidade Católica Portuguesa (FEP-UCP), Porto, Portugal; Associação Kosmicare, 4169-005 Porto, Portugal. Endereço postal: CEDH–FEP-UCP, R. de Diogo Botelho, 1327, 4169-005, Porto, Portugal. Endereço eletrónico: cvpires@ucp.pt ** Centro de Investigação para o Desenvolvimento Humano (CEDH), Faculdade de Educação e Psicologia da Universidade Católica Portuguesa (FEP-UCP), Porto, Portugal; Associação Kosmicare, 4169-005 Porto, Portugal. Endereço postal: CEDH–FEP-UCP, R. de Diogo Botelho, 1327, 4169-005, Porto, Portugal. Endereço eletrónico: mccarvalho@ucp.pt *** Centro de Investigação e Inovação em Educação (inED), Universidade do Porto (UP), Porto, Portugal. Endereço postal: inED–UP, R. Dr. Roberto Frias, 602,4200-465 Porto, Portugal. Endereço eletrónico: helena.moura. carvalho@gmail.com
A mechanistic model of ADHD as resulting from dopamine phasic/tonic imbalance during reinforcement learning

Attention deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder in children. Although the involvement of dopamine in this disorder seems to be established, the nature of dopaminergic dysfunction remains controversial. The purpose of this study was to test whether the key response characteristics of ADHD could be simulated by a mechanistic model that combines a decrease in tonic dopaminergic activity with an increase in phasic responses in cortical-striatal loops during learning reinforcement. To this end, we combined a dynamic model of dopamine with a neurocomputational model of the basal ganglia with multiple action channels. We also included a dynamic model of tonic and phasic dopamine release and control, and a learning procedure driven by tonic and phasic dopamine levels. In the model, the dopamine imbalance is the result of impaired presynaptic regulation of dopamine at the terminal level. Using this model, virtual individuals from a dopamine imbalance group and a control group were trained to associate four stimuli with four actions with fully informative reinforcement feedback. In a second phase, they were tested without feedback. Subjects in the dopamine imbalance group showed poorer performance with more variable reaction times due to the presence of fast and very slow responses, difficulty in choosing between stimuli even when they were of high intensity, and greater sensitivity to noise. Learning history was also significantly more variable in the dopamine imbalance group, explaining 75% of the variability in reaction time using quadratic regression. The response profile of the virtual subjects varied as a function of the learning history variability index to produce increasingly severe impairment, beginning with an increase in response variability alone, then accumulating a decrease in performance and finally a learning deficit. Although ADHD is certainly a heterogeneous disorder, these results suggest that typical features of ADHD can be explained by a phasic/tonic imbalance in dopaminergic activity alone.
"Are we only the bin?" : a study of Malmö's transition towards a sustainable waste society

Waste generation is rapidly increasing globally, estimating that 11 billion tonnes of solid waste is produced every year. Cities and urban areas generate large and concentrated waste flows due to the density and multitude of inhabitants. Both waste and how we choose to treat it creates negative impacts on natural, economic and societal systems, both globally and locally. Greenhouse gas emissions, natural resource depletion and technological lock-ins are only a few of many negative effects waste can cause. Malmo, Sweden’s third most populated city, is currently facing several waste challenges, such as increasing waste amounts due to rapid population growth and that incineration act as the main treatment process of municipal solid waste, preventing a circular material system and recycling of valuable resources. This thesis, using semi-structured interviews as well as a document review, investigate Malmo’s current strategic and practical work for achieving a transition towards a sustainable waste society; identifying gaps and challenges in Malmo’s current transition process; and lastly, explore potential future pathways to overcome these challenges and secure a continued transition process. Transition management has been used as an analytical framework to help understand the current waste situation in Malmo and to suggest potential future pathways for overcoming identified gaps and challenges. Several strategic and practical initiatives are currently in place in Malmo with the intention of climbing the waste hierarchy and promote a more sustainable waste situation. However, several gaps and challenges have been identified including lack of a clear collective transition vision, differentiating interpretation of waste goals and the waste hierarchy, unstable private-actor involvement and evaluation insecurity. Potential future pathways are development of a stronger multi-actor transition arena, implementing manufacturing requirements and using evaluation as a learning tool.
Allergic Asthma in the Era of Personalized Medicine

Allergic asthma is the most common asthma phenotype and is characterized by IgE sensitization to airborne allergens and subsequent typical asthmatic symptoms after exposure. A form of type 2 (T2) airway inflammation underlies allergic asthma. It usually arises in childhood and is accompanied by multimorbidity presenting with the occurrence of other atopic diseases, such as atopic dermatitis and allergic rhinitis. Diagnosis of the allergic endotype is based on in vivo (skin prick tests) and/or in vitro (allergen-specific IgE levels, component-resolved diagnosis (CRD)) documentation of allergic sensitization. Biomarkers identifying patients with allergic asthma include total immunoglobulin E (IgE) levels, fractional exhaled nitric oxide (FeNO) and serum eosinophil counts. The treatment of allergic asthma is a complex procedure and requires a patient-tailored approach. Besides environmental control involving allergen avoidance measurements and cornerstone pharmacological interventions based on inhaled drugs, allergen-specific immunotherapy (AIT) and biologics are now at the forefront when it comes to personalized management of asthma. The current review aims to shed light on the distinct phenotype of allergic asthma, ranging over its current definition, clinical characteristics, pathophysiology and biomarkers, as well as its treatment options in the era of precision medicine.
Quality Service Delivery Between Service Failure and Service Recovery in Hospitality Industry - A Place for Enjoyment

Having a good customer satisfaction by providing excellent quality services are important in running a successful hospitality business for this, management of any establishment needs to deliver a quality service and quality product because Guzo R (2010, Gronoos, 1990; Parasuraman et Guzo R al., 1988) believe having customer satisfaction are critical factors for success of any business. Also, Managers need to understand how to encourage their staff to implement quality measures to assure service guaranty and retain customer relationship to implicate the re-visit and deliver positive word of mouth. Kristen A and Kozub R (2008). Given the above considerations and highlight the importance of the customer satisfaction, this study stresses the significant of delivery quality service and recover the service failure in order to guarantee promises company make to improve customer satisfaction
Force Estimation during Cell Migration Using Mathematical Modelling

Cell migration is essential for physiological, pathological and biomedical processes such as, in embryogenesis, wound healing, immune response, cancer metastasis, tumour invasion and inflammation. In light of this, quantifying mechanical properties during the process of cell migration is of great interest in experimental sciences, yet few theoretical approaches in this direction have been studied. In this work, we propose a theoretical and computational approach based on the optimal control of geometric partial differential equations to estimate cell membrane forces associated with cell polarisation during migration. Specifically, cell membrane forces are inferred or estimated by fitting a mathematical model to a sequence of images, allowing us to capture dynamics of the cell migration. Our approach offers a robust and accurate framework to compute geometric mechanical membrane forces associated with cell polarisation during migration and also yields geometric information of independent interest, we illustrate one such example that involves quantifying cell proliferation levels which are associated with cell division, cell fusion or cell death.
Operation twins: production-intralogistics synchronisation in Industry 4.0

ABSTRACT The widespread adoption of Industry 4.0 technologies is revolutionising how manufacturing operations are managed and done. This revolution drives manufacturing practitioners to reevaluate their current manufacturing planning and control (MPC) strategies to maintain global competitiveness. The production and intralogistics (PiL) operations within traditional MPC systems are organised separately, which results in inferior overall solutions. PiL operations in a single factory are inherently coupled and interact with each other throughout the entire process, which needs synchronous organisation and operations. This paper introduces a novel concept of operations twins (OT), with vertical twinning and horizontal twining, for achieving PiL synchronisation by leveraging Industry 4.0 technologies and innovative operations management strategies. An Internet-of-Things (IoT)-based vertical twinning method is developed for real-time object-level data collection and information-sharing between PiL. A horizontal twinning mechanism is proposed to support real-time coordination of production and intralogistics operations with real-time information-sharing. A numerical study is carried out, and the results show that OT outperforms the widely used static and dynamic methods regarding the overall stability and typical measures such as makespan, average manufacturing time, and average tardiness under different levels of uncertainties.