Miracle-dz/UniFAR-FTUs huggingface dataset:
Screening out irrelevant cell-based models of disease

Author Affiliations *European Cell Based Assay Interest Group (www.eucai.org) 1Synthetic and Systems Biology Unit, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary. 2Imagopole-Citech, Institut Pasteur, France 3Technology Development Studio, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany 4Institute of Molecular Medicine, Trinity College Dublin, Ireland. 5Translational Cell Imaging Queensland (TCIQ), Institute of Health Biomedical Innovation Q ueensland, U niversity O f Technology, Australia. 6 Institut Curie, PSL Research University, Department of Translational Research, The Biophenics High-Content Screening Laboratory, Cell and Tissue Imaging Facility (PICTIBiSA), F-75005, Paris, France. 7Target Discovery Institute, University of Oxford, U.K. 8 Cellomics Unit, Cell Biology & Physiology Program; Cell & Developmental Biology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. 9Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. 10Faculty of Science, Leiden Academic Centre for Drug Research, Toxicology, Universiteit Leiden, The Netherlands. 11OcellO B.V. J.H Oortweg 21. 2333 CH, Leiden. The Netherlands 12Biomolecular Screening Facility, Swiss Federal Institute of Technology (EPFL), Switzerland. 13Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, U.K.
Enhancing Cloud Security: A Novel Approach to Intrusion Detection Using Feed Forward Neural Networks and Optimization Algorithm

: Cloud network is contributing more research options for researchers. Intrusion detection is an important function that can provide information security to the cloud environment. From the research, an Intrusion detection system (IDS) is one of the key areas involving security issues in the cloud environment. In this research paper, we propose an efficient intrusion detection system based on Feed Forward Neural Network (IFF - NN) along with Ant Lion optimization algorithms. The attacks are identified in the network layer of a cloud environment. The goal of the research is to improve the accuracy and error rate. The experimental results prove with high accuracy for detecting the attack. The proposed approach is executed using KDD99 dataset and compared with existing methods.
Assessing the Functional Properties of the TMCO 1 Sequence Variants by Using In Silico Analyses

Transmembrane and Coiled-Coil Domains 1 (TMCO1) protein is encoded by TMCO1 gene consists of 7 exons. Previous studies have identified multiple TMCO1 variants in patients with cerebro-facio-thoracic dysplasia (CFTD) and TMCO1 locus was also shown to be associated with primary open angle glaucoma (POAG). However, there are limited number of research exist reporting associations of the TMCO1 gene sequence variants and majority of the findings affirm the pathogenicity of the nonsense and frameshift TMCO1 variants and their associations with clinical phenotypes. Thus functional properties of the single nucleotide variants causing amino acid changes in the TMCO1 are yet to be comprehensively elucidated. In this study, we evaluated the effects of amino acid substitutions on protein structure, identified their putative roles in post-translational modifications (PTM) and in regulatory mechanism for TMCO1 protein. We classified 41 missense variants as pathogenic based on combined scores of common in silico tools (SIFT, MutationTaster2, Polyphen2). Of these 41 variants, four (p.K211Q, p.K105E, p.S235F, p.K237R) were identified to be located in PTMs and regulatory protein binding sites; thus they were proposed to be putative functional variants. Moreover, rs1387528611 (p.Lys128Gln) had also strong evidence (RegulomeDB score=2b) for its possible regulatory function. The results of our in silico analyses highlight the functional importance of the missense TMCO1 variants that may contribute to the TMCO1-associated disease phenotypes and further in vivo evaluation yet to be needed to uncover their role in human diseases.
Seeing the people through the trees: community-based ecotourism in Northern Thailand

In contrast to popular conventional trekking tours that dominate the Northern Thai tourist industry, this thesis explores community-based ecotourism, one of the alternative strategies currently being used among highland minority groups and NGOs in Northern Thailand. Ecotourism offers a unique strategy that embraces local aspirations for achieving self-determined sustainable development and is promoted locally and globally as a mechanism of achieving economic development alongside environmental conservation. An analysis of findings from participant observation, interviews, and secondary data gathered during fieldwork in 2002-2003, suggests that community-based ecotourism is likely to achieve only limited success on a small scale in terms of the immediate benefits it generates in host communities. Since ecotourism is premised on the commodification of nature and culture, it seems unlikely that ecotourism, which links people, tourism and the natural and cultural environments, will be a successful avenue for achieving long-term sustainability. F o r m y grandmothers, w h o a b o CovepeopCe and t rees .
Lake Mead National Recreation Area: An Ethnographic Overview

ix Introduction 1 Overview objectives 4 The Moj ave 6 Territory and environment 6 Early contacts 9 Subsistence 14 Relations with neighboring groups 23 The Chemehuevi and the Southern Paiute 27 Territory and Environment 27 Early contacts 34 Subsistence 37 Environmental manipulation 50 Social organization 51 The Hualapai 54 Territory and environment 54 Early contacts 56 Subsistence 57 Social organization 64 Lake Mead inter-ethnic social organization 68 Bibliography 71 References cited 71 Additional references 77
PI-1404 New Evidence on Mutual Fund Performance : A Comparison of Alternative Bootstrap Methods

This paper compares the two bootstrap methods of Kosowski et al. (2006) and Fama and French (2010) using a new dataset on equity mutual funds in the UK. We find that: the average equity mutual fund manager is unable to deliver outperformance from stock selection or market timing, once allowance is made for fund manager fees and for a set of common risk factors that are known to influence returns; 95% of fund managers on the basis of the first bootstrap and almost all fund managers on the basis of the second bootstrap fail to outperform the zero-skill distribution net of fees; and both bootstraps show that there are a small group of “star” fund managers who are able to generate superior performance (in excess of operating and trading costs), but they extract the whole of this superior performance for themselves via their fees, leaving nothing for investors.
P2-130 Epidemiology of hypertension in an urban Sri Lankan population

Introduction Hypertension is a common risk factor for cardiovascular disease. In Sri Lanka, despite the existence of a universal free health system, services are not available for routine screening of hypertension in the general population. This paper aims to describe the epidemiology of hypertension in 35–64 year old residents in Ragama Medical Officer of Health area in the Gampaha district, Sri Lanka. Methods An age-stratified random sample of 4400 adults between 35 and 64 years of age drawn from the population based electoral list, was invited for a screening programme on cardiovascular risk factors. Socio-demographic and risk factor related data and anthropometric and blood pressure measurements were obtained by trained research assistants. Blood was obtained for relevant biochemical investigations. Results The prevalence of hypertension (systolic >139 mm Hg and/or diastolic >89 mm Hg) in 2986 subjects (Males 45%), was 30.4% (27.8% in males; 32.5% in females). 31.8% (n=288) were previously undetected. Of the known hypertensives, 19.5% were not on anti-hypertensive medication and only 32.1% were controlled (defined by systolic <140 mm Hg and diastolic <90 mm Hg). Factors associated with hypertension in both males and females were body mass index, waist circumference, fasting blood glucose and serum triglycerides. Conclusions The prevalence observed is comparable to the prevalences of developed countries with relatively older populations. A considerable proportion of known hypertensives are not on treatment and the observed poor control indicates problems in drug compliance. Interventions targeting lifestyle modification and drug compliance are essential to control adverse outcomes of hypertension.
Stock Market Volatility and Learning ∗

Allowing for small deviations from rational expectations in a standard consumption-based asset pricing model strongly improves empirical performance. Investors behave rationally given a consistent set of beliefs about variables that are exogenous to their decision problem, but their beliefs may deviate slightly from rational expectations beliefs. As agents learn to improve their forecasts, returns display momentum and mean reversion and asset prices become excessively volatile, the price-dividend ratio displays persistence, long-horizon returns become predictable and a risk premium emerges. Quantitative model performance is comparable to the rational expectations model of Campbell and Cochrane (1999) but achieved with standard time separable preferences and lower risk aversion. The findings are robust to the learning rule used and other model features. What is key is that agents learn about the behavior of prices using past observations of price. JEL Class. No.: G12, D84 ∗Thanks go to Andy Abel, Davide Debortoli, Luca Dedola, George Evans, Katharina Greulich, Seppo Honkapohja, Ricardo Lagos, Erzo Luttmer, Bruce McGough, Bruce Preston, Jaume Ventura, Joachim Voth, Iván Werning and Raf Wouters for interesting comments and suggestions. We particularly thank Philippe Weil for a very interesting and stimulating discussion. Thanks go also to seminar participants at CERGE-EI in Prague, U. Autònoma de Barcelona, New York Fed, Fed. Reserve Bank of Minneapolis, NYU, MIT, Board of Governors, Carnegie-Mellon U. , U. of Pennsylvania and Cambridge U, and to conference participants at CREI-CEPR Conference on ‘Bubbles — Theory and Policy Implications’ at U. Pompeu Fabra, ESSIM 2006 in Tarragona, Econometric Society European Meeting 2006, 4th IMOP Conference on Dynamic Macroeconomics in Hydra, SCE 2006 Conference, St. Louis Learning Workshop 2006, 2007 Dynare Conference in Paris, 1st Swiss National Bank Research Conference in Zurich, 2007 Bank of Finland CEPR Conference in Helsinki, AEA Meetings 2008 in New Orleans. Sofía Bauducco and Davide Debortoli have supported us with outstanding research assistance. Marcet acknowledges support from CIRIT (Generalitat de Catalunya), Plan Nacional project ECO2008-04785/ECON (Ministry of Science and Education, Spain), CREI, the Barcelona GSE Research Network and the Wim Duisenberg fellowship from the European Central Bank. The views expressed herein are solely those of the authors and do not necessarily reflect the views of the European Central Bank. Author contacts: Klaus Adam (Mannheim University and CEPR) adam@uni-mannheim.de; Albert Marcet (Institut d’Anàlisi Econòmica CSIC) albert.marcet@iae.csic. es; Juan Pablo Nicolini (Universidad Torcuato di Tella) juanpa@utdt.edu.
Effect of experimental hookworm infection on insulin resistance in people at risk of Type 2 Diabetes: a randomized, placebo-controlled trial

The reduced prevalence of insulin resistance and type 2 diabetes (T2D) in countries with endemic parasitic worm infections suggests a protective role for worms against metabolic disorders, however clinical evidence has been non-existent. This 2-year randomized controlled trial of hookworm infection in 40 people at risk of T2D involved treatment with either 20 or 40 Necator americanus third-stage larvae (L3) or Placebo. Primary outcome was safety, with homeostatic model assessment of insulin resistance (HOMA-IR), fasting blood glucose (FBG), and body mass being the key metabolic outcomes. Adverse events were more frequent in hookworm-treated participants, where 44% experienced transient gastrointestinal symptoms. FBG and HOMA-IR were significantly lowered in both hookworm-treated groups at 1-year, and body mass was significantly lowered after L3-20 treatment at 2-years. Overall, hookworm infection was well tolerated in people at risk of T2D, and were associated with improved insulin resistance, warranting further exploration of the benefits of hookworms on metabolic health.
Rapid-Sequence Intubation

Objective: To summarize published data regarding the steps of rapid-sequence intubation (RSI); review premedications, induction agents, neuromuscular blockers (NMB), and studies supporting use or avoidance; and discuss the benefits and deficits of combinations of induction agents and NMBs used when drug shortages occur. Data Source: A search of Medline databases (1966–October 2013) was conducted. Study Selection and Data Extraction: Databases were searched using the terms rapid-sequence intubation, fentanyl, midazolam, atropine, lidocaine, phenylephrine, ketamine, propofol, etomidate thiopental, succinylcholine, vecuronium, atracurium, and rocuronium. Citations from publications were reviewed for additional references. Data Synthesis: Data were reviewed to support the use or avoidance of premedications, induction agents, and paralytics and combinations to consider when drug shortages occur. Conclusions: RSI is used to secure a definitive airway in often uncooperative, nonfasted, unstable, and/or critically ill patients. Choosing the appropriate premedication, induction drug, and paralytic will maximize the success of tracheal intubation and minimize complications.
Cranial Neuroimaging and Clinical Neuroanatomy: Atlas of MR Imaging and Computed Tomography

1. Introduction 2. Neuroimaging and Guideline Structures 3. Topography of the Facial Skeleton and its Cavities in Multiplanar Parallel Slices 4. Topography of the Pharynx and Craniocervical Junction in Multiplanar Parallel Slices 5. Topography of the Neurocranium and its Intracranial Spaces and Structures in Multiplanar Parallel Slices 6. Neurofunctional Systems 7. Neurotransmitters and Neuromodulators 8. Material and Methods 9. Literature 10. Index
BORE-HOLE SURVEY AT DYE

A BST R ACT. In 1983 three d irec ti o nal su rveys were made in the bore hole from whi ch a deep ice core was o bta ined in the summers of 19798 1. The incl ina tion and azim ut h of th e bo re hole were measured o n three surveys, tem perature was included on two surveys, nuid pressure a nd hole diameter on o ne of th e surveys. Fl uid-pressu re measu remen ts show th at the iceoverbu rden pressure was undercom pensated in the upper few hundred meters and overcompensated at the bottom of the ho le. Diameter measuremf' nts show cl osure in the uppe r portion and ex pansio n nea r the bo ttom begin ning at the transition from th e Holocene lO Wisconsin ice at 1784 m. Th e hole expansion and increase in incl in ation correla te wi th d ust and sil t content in the \\'isconsin ice. Cha nges in azimuth are d ue to Row oflhe ice and are co nsistent wi th the direc ti on of Aow at the surface. Temperatu re measurements show that th e hole is a t or nea r eq uilibrium. The gradient of 0,012 K /m below 1400 In is less th a n the 0.018 K/m a t Camp Century. There is a sl ig ht reduction in grad ient near the bottom from internal fricti on in the silt y ice.
Earthquake source characterization using 3D numerical modeling

To understand the physics of earthquakes, it is important to know what happens during individual events. Dissembling the information about the source process from the recorded seismograms is a difficult and non-unique process, as there are severe trade-offs between many of the source parameters. In this thesis we attempt to add information from frequencies not used during the initial modeling of individual events to put more constraints on the source process, to learn about specific source parameters important to the physics of earthquakes. We model earthquakes using a spectral element method for wave-propagation that accurately accounts for the Earth's 3D elastic structure. We study the rupture speed of the 2001 Kunlun, China earthquake, the continuity of slip during the 1998 Balleny Islands event and the duration of slip during the 2004 Sumatra-Andaman, Indonesia earthquake. Finally, we explore the feasibility of using adjoint methods to learn about the earthquake source.
Assimilation of SeaWiFS Ocean Chlorophyll Data into a Three-.Dimensional Global OceanModel

Assimilation of satellite ocean color data is a relatively new phenomenon in ocean sciences. However, with routhe observations &om the Sea-viewing Wide Field-of-view Sensor (SeaWiFS), launched in late 1997, and now with new data from the Moderate Resolution h q p g SpectroraQometer (MODIS) Aqua, there is increasing interest in ocean color data assimilation Here SeaWiFS chlorophyll data were assimilated with an thredimaiod global ocean model. The assimilation improved estimates of ruzd primary w o n relative to a free-run (no assimilation) model. This r e m the first at.Eempt at ocean color data assimilation using NASA satellites in a global results suggest the potential of assimilation of satellite ocean chlorophyll data models.
CAMBRIDGE WORKING PAPERS IN ECONOMICS JANEWAY INSTITUTE WORKING PAPERS Granular Banking Flows and Exchange-Rate Dynamics

Using data on the external assets and liabilities of global banks based in the UK, the world’s largest centre for international banking, we identify exogenous cross-border banking flows by constructing novel Granular Instrumental Variables. In line with the predictions of a new granular international banking model, we show empirically that cross-border flows have a significant causal impact on exchange rates. A 1% increase in UK-based global banks’ net external US dollar-debt position appreciates the dollar by 2% against sterling. While we estimate that the supply of dollars from abroad is price-elastic, our results suggest that UK-resident global banks’ demand for dollars is price-inelastic. Furthermore, we show that the causal effect of banking flows on exchange rates is state dependent, with effects twice as large when banks’ capital ratios are one standard deviation below average. Our findings showcase the importance of banks’ risk-bearing capacity for exchange rate dynamics and, therefore, for insulating their domestic economies from global financial shocks.
Fat&MuscleDB: A database to understand tissue growth processes contributing to body or muscle composition

To minimise unnecessary redundancy in research efforts by a better use of available data, we present a web-based database and data-mining platform named Fat&MuscleDB. Genomics on muscle and adipose tissue growth has generated huge amount of data which are available in journals and in databases. Unfortunately these data are scattered on the Internet in a heterogeneous format. Thus, it is difficult to exploit them efficiently. We hypothesise that these data can allow identifying genes or proteins involved in adipose and muscle tissues development contributing to body or muscle composition, two key criteria of carcass and meat quality. Currently, Fat&MuscleDB contains genomic expression data and differential abundance data from about 100 publications and 75 GEO datasets. These data can be queried, visualised, and downloaded in different ways: the data visualisation of each reference, the search of transcripts or proteins in references, and the data aggregation based on criteria of adipose and muscle growth. The aggregation function of Fat&MuscleDB is illustrated through two questions: ''What are the proteins secreted by muscles? " and ''What are the transcripts and proteins involved in the growth of muscle tissue from genetic origins of bovine? ''.
Export-led industrialisation and growth: Korea's economic miracle, 1962-1989

The period 1962-89 witnessed a remarkable transformation of the South Korean economy, from being poverty ridden to the attainment of the status of newly industrialised nation. This transformation was achieved through the adoption of an outward oriented industry led strategy, based, particularly during the period of the 1970s, upon the development of large-scale industrial conglomerates and the attainment of economies of scale and technology to achieve international competitiveness. By the early 1980s this strategy had resulted in major structural imbalances, a weakened financial section, heavy concentration in domestic markets, and a repressed development of small and medium enterprises. By the end of the 1980s, despite attempts at economic reform during this decade, the structural and financial problems remained which were to prove the country’s undoing during the financial and economic crisis of 1997-98. This issue of whether Korea’s performance during this period can be described as an economic miracle is also reviewed. The empirical evidence on this issue is mixed and no conclusive evidence can be drawn. However, despite this, the achievements of the Korean economy during the period under discussion should not be underestimated.
Reliable Distributed Systems: Technologies, Web Services, and Applications

* Preface * Introduction * A User's Guide to This Book * Trademarks * Part I: Basic Distributed Computing Technologies * Fundamentals * Basic Communication Services * High Assurance Communication * Remote Procedure Calls and the Client/Server Model * Styles of Client/Server Computing * CORBA: The Common Object Request Broker Architecture * System Support for Fast Client/Server Communication * Part II: Web Technologies * The World Wide Web * Major Web Technologies * Web Services * Related Internet Technologies * Platform Technologies * Part III: Reliable Distributed Computing * How and Why Computer Systems Fail * Overcoming Failures in a Distributed System * Dynamic Membership * Group Communication Systems * Point to Point and Multi-group Considerations * The Virtual Synchrony Execution Model * Consistency in Distributed Systems * Part IV: Applications of Reliability Techniques * Retrofitting Reliability into Complex Systems * Software Architectures for Group Communication * Part V: Related Technologies * Security Options for Distributed Settings * Clock Synchronization and Synchronous Systems * Transactional Systems * Peer-to-Peer Systems and Probabilistic Protocols * Prospects for Building Highly Assured Web Services * Other Distributed and Transactional Systems * Appendix: Problems * Bibliography * Index
Quantification of the contribution of nitrogen from septic tanks to ground water in Spanish Springs Valley, Nevada

Analysis of total dissolved nitrogen concentrations from soil water samples collected within the soil zone under septic tank leach fields in Spanish Springs Valley, Nevada, shows a median concentration of approximately 44 milligrams per liter (mg/L) from more than 300 measurements taken from four septic tank systems. Using two simple mass balance calculations, the concentration of total dissolved nitrogen potentially reaching the groundwater table ranges from 25 to 29 mg/L. This indicates that approximately 29 to 32 metric tons of nitrogen enters the aquifer every year from natural recharge and from the 2,070 houses that use septic tanks in the densely populated portion of Spanish Springs Valley. Natural recharge contributes only 0.25 metric tons because the total dissolved nitrogen concentration of natural recharge was estimated to be low (0.8 mg/L). Although there are many uncertainties in this estimate, the sensitivity of these uncertainties to the calculated load is relatively small, indicating that these values likely are accurate to within an order of magnitude. The nitrogen load calculation will be used as an input function for a ground-water flow and transport model that will be used to test management options for controlling nitrogen contamination in the basin.