Miracle-dz/UniFAR-FTUs huggingface dataset:
The Human Microbiome and Its Role in Musculoskeletal Disorders

Musculoskeletal diseases (MSDs) are characterized as injuries and illnesses that affect the musculoskeletal system. MSDs affect every population worldwide and are associated with substantial global burden. Variations in the makeup of the gut microbiota may be related to chronic MSDs. There is growing interest in exploring potential connections between chronic MSDs and variations in the composition of gut microbiota. The human microbiota is a complex community consisting of viruses, archaea, bacteria, and eukaryotes, both inside and outside of the human body. These microorganisms play crucial roles in influencing human physiology, impacting metabolic and immunological systems in health and disease. Different body areas host specific types of microorganisms, with facultative anaerobes dominating the gastrointestinal tract (able to thrive with or without oxygen), while strict aerobes prevail in the nasal cavity, respiratory tract, and skin surfaces (requiring oxygen for development). Together with the immune system, these bacteria have coevolved throughout time, forming complex biological relationships. Changes in the microbial ecology of the gut may have a big impact on health and can help illnesses develop. These changes are frequently impacted by lifestyle choices and underlying medical disorders. The potential for safety, expenses, and efficacy of microbiota-based medicines, even with occasional delivery, has attracted interest. They are, therefore, a desirable candidate for treating MSDs that are chronic and that may have variable progression patterns. As such, the following is a narrative review to address the role of the human microbiome as it relates to MSDs.
Relationship of uddeR and teat moRphology to milking chaRacteRistics and uddeR health deteRmined by ultRasonogRaphic examinations in daiRy cows*

the aim of this study is to call attention to the possibility of using ultrasonography as a useful tool for the evaluation of morphological characteristics of the udder and teats in dairy cows in relation to milking characteristics and udder health. a total of 26 dairy cows of the holstein breed in the first (n = 13) and second lactation (n = 13) were investigated with a linear array ultrasound probe. Recovery of the teat internal parameters after milking was determined by ultrasonographic scanning. Teat canal length, teat canal diameter and teat wall thickness of 103 teats were evalu - ated from 622 measurements before and directly after milking and every 15 minutes until 1 hour after milking (6 measurements). The most significant differences in internal proportions were de - termined within those values measured before and immediately after milking. the dynamics of changes in the length of the teat canal demonstrated the extension by 27%. a sudden restoration of the initial length by 11% was detected one hour after milking. Differences in teat canal diameter were significant at P<0.01 between the 1st and 4th measurement. The initial extension was 17% immediately after milking and the restoration about 9% one hour after milking. the wall thickness was strengthened during the 2nd measurement immediately after milking in comparison with the 1st measurement before milking (P<0.01). Significant differences in the wall thickness were detected between the 1st and 2nd measurement (+26%; P<0.01) and between the 2nd and 3rd measurement. the ultrasonographic scanning of the teat parameters was a useful tool to study teat changes caused by milking.
Bibliometric Mapping Analysis of the Cyberbullying Phenomenon Among Children

Cyberbullying has become a global problem. This phenomenon is not only a trend among teenagers, but has penetrated among children. The impact is felt so significantly by both perpetrators and victims of cyberbullying. The purpose of this study is to map the trend of the cyberbullying phenomenon among children over the past decade. Data search through data-based Scopus with keywords "cyberbullying" and "children", during 2014-2023. The results showed that searching for articles using keywords resulted in 1,001 articles from journals and conference papers only. The development of cyberbullying reality publications experienced the highest increase in 2019 by 14.23%. The largest subject areas are medicine and psychology. This provides an opportunity in the field of education, that the theme of cyberbullying and its impact on the field of education still needs to be deepened in research and publication.
Surface ultraviolet radiation

Abstract One of the main concerns regarding a decrease in stratospheric ozone is the consequential increasein the amount of ultraviolet (UV) radiation that reaches the lower atmosphere and the Earth's surface. Radiationat UV wavelengths where ozone absorbs strongly is detrimental to most biological species, including humanbeings, so a decrease in stratospheric ozone could have a significant impact on the biosphere. This concern hasled to a significant increase in surface UV radiation research over the last two decades since the ratification ofthe Montreal Protocol. Studies include investigations into understanding the complicated absorption and scatteringprocesses involved in the radiative transfer of UV through the atmosphere as well as research on theimpacts of changes in UV radiation. Factors affecting surface UV radiation will be discussed, resources used tostudy surface UV radiation will be described and progress made in our understanding of surface UV radiationover the past two decades will be reviewed.
Oriented microfractures in Cajon Pass Drill Cores: Stress field near the San Andreas Fault

Oriented cores recovered from the Cajon Pass deep drill hole near the San Andreas fault in southern California were examined under both optical and electronic microscopes to study the distributrion and orientation of microfractures in the rocks. The objective was to determine whether there may be any systematic relationship between the microfractures in the rocks and the stress field in this area and to test the hypothesis that the observed shear wave birefringence can be caused by in situ microfractures. Three sets of microfractures, all dipping subvertically, appear in the rock cores studied. The oldest set (set 2) consists of mineralized microfractures with an orientation of N40°–50°E. A younger set (set 3), less prominent in appearance, consists of mineralized microfractures with an orientation of N68°–76°E. The most recent set (set 1) consists of open microfractures with fresh walls, with orientation of N14°–28°W. The two mineralized sets of microfractures were most likely formed in situ. The last set of microfractures with fresh walls was probably formed during core extraction and stress release. Based on elementary consideration in fracture mechanics, the second and the last sets (sets 3 and 1, respectively) of microfractures are consistent with a mean orientation of the present state of stress at the Cajon Pass drilling site, with a mean direction of the maximum horizontal stress at about N70°E, as determined from recent analyses of stress-induced well bore breakouts, hydraulic fractures, and shear wave birefringence. The oldest set of microfractures (set 2) could have formed during an earlier strain event when the crystalline basement beneath the Cajon Pass area experienced an earlier strain episode when the basement block occupied a more northerly position during which the maximum horizontal stress was oriented at about N45°E. On the other hand, it could also have formed under the same state of stress as the present one, but the basement block could have rotated counterclockwise.
Physicians’ Compliance With Order Entry Forms for Intravenous Pantoprazole in a Tertiary Care Hospital

The widespread inappropriate use of intravenous (IV) pantoprazole, due to its high cost, is a substantial issue. To improve its rational use, an order entry form (OEF) based on the institutional guideline, was implemented. Physicians were required to fill an OEF upon administration of IV pantoprazole. We aimed to evaluate the compliance of physicians as well as the accuracy of filled OEFs six months after the implementation. The study was conducted in a tertiary care teaching hospital in Tehran. Chart review was performed for all patients with an IV pantoprazole order. IV pantoprazole OEFs received by the hospital pharmacy for these patients were evaluated in terms of quantity and quality (e.g., completeness, accuracy of filled items, etc.). Only for 270 (62%) patients, OEFs were received by the hospital pharmacy. Indications were specified in 199 (73.5%) forms, and their agreement with the forms filled by the researcher was 37.8%. The most frequent indication specified in OEFs was stress ulcer prophylaxis (40.7%). IV pantoprazole administration was rational only in 15.9% of cases. The emergency ward had the highest frequency of orders (57.9%), while having the lowest fill rate (56.7%) among the wards with the highest number of orders. The disagreement between the researcher and the OEFs regarding the need for IV medication was 39.5%. This study demonstrated that the compliance of physicians with the accurate completion of OEFs was suboptimal. It seems that for long-lasting changes in IV pantoprazole utilization patterns, barriers should be determined, and additional methods such as ongoing educational seminars or feedback might be needed along with OEF.
Tryptophan metabolism-related gene expression patterns: unveiling prognostic insights and immune landscapes in uveal melanoma

Uveal melanoma (UVM) remains the leading intraocular malignancy in adults, with a poor prognosis for those with metastatic disease. Tryptophan metabolism plays a pivotal role in influencing cancerous properties and modifying the tumor’s immune microenvironment. In this study, we explore the relationship between tryptophan metabolism-related gene (TRMG) expression and the various features of UVM, including prognosis and tumor microenvironment. Our analysis included 143 patient samples sourced from public databases. Using K-means clustering, we categorized UVM patients into two distinct clusters. Further, we developed a prognostic model based on five essential genes, effectively distinguishing between low-risk and high-risk patients. This distinction underscores the importance of TRMGs in UVM prognostication. Combining TRMG data with gender to create nomograms demonstrated exceptional accuracy in predicting UVM patient outcomes. Moreover, our analysis reveals correlations between risk assessments and immune cell infiltrations. Notably, the low-risk group displayed a heightened potential response to immune checkpoint inhibitors. In conclusion, our findings underscore the dynamic relationship between TRMG expression and various UVM characteristics, presenting a novel prognostic framework centered on TRMGs. The deep connection between TRMGs and UVM’s tumor immune microenvironment emphasizes the crucial role of tryptophan metabolism in shaping the immune landscape. Such understanding paves the way for designing targeted immunotherapy strategies for UVM patients.
Real-Time Predictive Energy-Saving Control for Electric Vehicle Based on Road Slope Prediction

Predictive energy-saving control (PEC) is aimed at reducing energy consumption by designing the vehicle speed while considering future road and traffic information. In particular, the slope of the road ahead is necessary and critical for PEC. This paper proposes a road slope prediction method for production vehicles that uses the nonlinear autoregressive (NAR) neural network model based on road slope sensors. To adaptively balance the energy savings and trip time, this paper proposed a real-time variable weight PEC method for a four-wheel-drive (4WD) intelligent electric vehicle. The weight coefficients are automatically changed according to the characteristics of the road slope, where the vehicle energy-saving rate on the steep downhill road can be maximized. The results of real-time simulation on the dSPACE platform indicated that the road slope predictive model can be run in real time and adapted to changes in road slope and speed. The root mean square error (RMSE) of the predictive results is 0.3063. On a steep downhill road, the energy-saving rate of the proposed PEC method can reach 30.87% at a small expense of time of 3.75%. On uphill and flat roads, energy can be saved by 6.35% at a time cost of 3.0%. Compared with the PEC with constant weight factors, the two control objectives of energy savings and traveling time can be better balanced on various types of roads.
Fracturesfor Diagnosis of Craniosynostosis and Projections of the Calvaria: A New Approach Three-dimensional CT Maximum Intensity

Summary: three-dimensional CT maximum intensity projection (MIP) can depict suture patency, extent of synos-tosis (ie, complete versus incomplete bone bridging), fracture extent and conspicuity, and 3D calvarial deformity as a single set of projections in children with suspected craniosynostosis or skull fracture. Three-dimensional CT MIP may provide, in only eight views, all the required information to make the diagnosis of craniosynostosis and calvarial fracture extent currently requiring the combined information of 3D CT shaded surface displays and 2D axial CT images (a total of 58 views), and in some cases complementary skull radiographs. Three-dimensional MIP can be added to calvarial helical (spiral) CT imaging with only 5 minutes of additional postprocessing time.
Study on the Antioxidant Effect of Shikonin-Loaded β-Cyclodextrin Forming Host–Guest Complexes That Prevent Skin from Photoaging

When the skin is overexposed to ultraviolet rays, free radicals will accumulate in the skin, causing lipid damage and even inducing photoaging of the skin. Combination therapy with antioxidant drugs is a good choice for topical treatment of skin photoaging due to its special physiological structure. In this paper, shikonin was encapsulated in β-cyclodextrin (SH-β-CD) by the precipitation crystallization method, which delayed the release of the drug and increased drug solubility. The average diameter of SH-β-CD was 203.0 ± 21.27 nm with a zeta potential of −14.4 ± 0.5 mV. The encapsulation efficiency (EE%) was 65.9 ± 7.13%. The results of the in vitro permeation across the dialysis membrane and ex vivo transdermal release rates were 52.98 ± 1.21% and 88.25 ± 3.26%, respectively. In vitro antioxidant and antilipid peroxidation model assay revealed the antioxidant potential of SH and SH-β-CD. In the mice model of skin photoaging, SH and SH-β-CD had a recovery effect on the skin damage of mice, which could significantly increase the superoxide dismutase (SOD) activity in the skin. Briefly, SH-β-CD had an obvious therapeutic effect on the skin photoaging of mice caused by UV, and it is promising in skin disease treatment and skin care.
Molecular Epidemiologic and Geo-Spatial Characterization of Staphylococcus aureus Cultured from Skin and Soft Tissue Infections from United States-Born and Immigrant Patients Living in New York City

(1) Background: With increasing international travel and mass population displacement due to war, famine, climate change, and immigration, pathogens, such as Staphylococcus aureus (S. aureus), can also spread across borders. Methicillin-resistant S. aureus (MRSA) most commonly causes skin and soft tissue infections (SSTIs), as well as more invasive infections. One clonal strain, S. aureus USA300, originating in the United States, has spread worldwide. We hypothesized that S. aureus USA300 would still be the leading clonal strain among US-born compared to non-US-born residents, even though risk factors for SSTIs may be similar in these two populations (2) Methods: In this study, 421 participants presenting with SSTIs were enrolled from six community health centers (CHCs) in New York City. The prevalence, risk factors, and molecular characteristics for MRSA and specifically clonal strain USA300 were examined in relation to the patients’ self-identified country of birth. (3) Results: Patients born in the US were more likely to have S. aureus SSTIs identified as MRSA USA300. While being male and sharing hygiene products with others were also significant risks for MRSA SSTI, we found exposure to animals, such as owning a pet or working at an animal facility, was specifically associated with risk for SSTIs caused by MRSA USA300. Latin American USA300 variant (LV USA300) was most common in participants born in Latin America. Spatial analysis showed that MRSA USA300 SSTI cases were more clustered together compared to other clonal types either from MRSA or methicillin-sensitive S. aureus (MSSA) SSTI cases. (4) Conclusions: Immigrants with S. aureus infections have unique risk factors and S. aureus molecular characteristics that may differ from US-born patients. Hence, it is important to identify birthplace in MRSA surveillance and monitoring. Spatial analysis may also capture additional information for surveillance that other methods do not.
Airborne Pesticides from Agricultural Practices: A Critical Review of Pathways, Influencing Factors, and Human Health Implications

This critical review examines the release of pesticides from agricultural practices into the air, with a focus on volatilization, and the factors influencing their dispersion. The review delves into the effects of airborne pesticides on human health and their contribution to anthropogenic air pollution. It highlights the necessity of interdisciplinary research encompassing science, technology, public policy, and agricultural practices to effectively mitigate the risks associated with pesticide volatilization and spray dispersion. The text acknowledges the need for more research to understand the fate and transport of airborne pesticides, develop innovative application technologies, improve predictive modeling and risk assessment, and adopt sustainable pest management strategies. Robust policies and regulations, supported by education, training, research, and development, are crucial to ensuring the safe and sustainable use of pesticides for human health and the environment. By providing valuable insights, this review aids researchers and practitioners in devising effective and sustainable solutions for safeguarding human health and the environment from the hazards of airborne pesticides.
EXCEPTIONAL ANTIOXIDANT EFFECT OF URTICA DIOICA EXTRACT ON MOTILITY AND SOME OTHER POST THAWED GOAT SEMEN CHARACTERISTICS

This study was carried out to examine the effects of Urtica dioica extract on goat cryopreserved semen quality. The ejaculates of Markhoz goats (n = 12) were collected by an electro-ejaculator. The semen was diluted and supplemented with different concentration of aqueous or hydroalcoholic Urtica dioica extract of aerial or root parts as follows: aerial-aqueous (AA1 5μg/ml , AA2 15μg/ml and AA3 45μg/ml ); aerial-ethanolic (AE1 5μg/ml , AE2 15μg/ml and AE3 45μg/ml ); root aqueous (RA1 5μg/ml , RA2 15μg/ml and RA3 45μg/ml ); root-ethanolic (RE1 5μg/ml , RE 215μg/ml and RE3 45μg/ml ) and control (CCC 0mg/ml ) without additives. After thawing, sperm samples were subjected to viability, acrosome integrity, plasma membrane integrity, motility, sperm chromatin dispersion (SCD) and concentration of malondialdehyde (MDA) assays. Addition of AA1 5μg/ml to the extender significantly (P < 0.05) improved progressive motility, viability, plasma membrane integrity, acrosome integrity, and DNA integrity of the semen samples. Sperm viability and plasma membrane integrity in aqueous extract (both aerial & root parts)-supplemented extenders were relatively higher, as compared to the control. Moreover, a significant decrease in MDA concentration was detected in semen supplemented with Urtica dioica extract treatments. In conclusion, the results indicate that 5μg/ml of aqueous extract of Urtica dioica aerial part improved sperm quality and could be recommended as an additive to the extender for cryopreservation. This study shows a novel approach in goat semen cryopreservation due to the remarkable influence of Urtica dioica on post-thawed sperm parameters.
Revisão integrativa das intervenções para prevenção da obesidade infantil: perspectivas de sucesso e limitações

O objetivo deste artigo consiste em realizar uma análise abrangente da literatura que aborda as intervenções mais eficazes na prevenção da obesidade infantil, analisando suas perspectivas de sucesso e identificando suas limitações. Esta revisão integrativa se baseou na busca de artigos em inglês, português e francês, publicados entre 2005 e 2023, obtidos a partir das fontes de pesquisa Scopus e PubMed. Observa-se que as intervenções comunitárias e familiares têm o potencial de impactar positivamente os níveis de atividade física e a melhoria da alimentação nas crianças, sendo sua eficácia variante de acordo com diversos fatores, incluindo o contexto social, cultural e individual.
Tropical Atlantic Decadal Oscillation and Its Potential Impact on the Equatorial Atmosphere–Ocean Dynamics: A Simple Model Study

Simple coupled atmosphere–ocean models are used to study the potential influence of the tropical Atlantic Ocean decadal oscillation on the equatorial Atlantic atmosphere–ocean dynamics. Perturbing the model tropical Atlantic at the extratropics (25°–30°) with a decadal frequency, interhemispheric SST dipole mode emerges due to the wind–evaporation–SST feedback. Near the equator, a cross-equatorial oceanic gyre develops owing to the dipole-induced wind stress curl. Once formed, this oceanic gyre transports surface water across the equator from the cold to the warm hemisphere in the western boundary region and from the warm to the cold hemisphere in the Sverdrup interior. Interestingly, this occurs during both the positive and negative phases of the dipole oscillation, thus producing a persistent positive zonal SST gradient along the equator. Bjerknes-type feedback later kicks in to further strengthen the equatorial SST anomaly. Eventually, this feature grows to a quasi-stationary stage sustaining the equatorial westerly wind anomalies, thus also causing the depression (uplift) of the equatorial thermocline in the east (west), a condition similar to the Atlantic Nino. The dynamic relationship between the dipole SST oscillation and the equatorial thermocline suggests that a strengthening (weakening) of the dipole mode corresponds to a weakening (strengthening) of the equatorial thermocline slope.
Radiometals in Imaging and Therapy: Highlighting Two Decades of Research

The present article highlights the important progress made in the last two decades in the fields of molecular imaging and radionuclide therapy. Advancements in radiometal-based positron emission tomography, single photon emission computerized tomography, and radionuclide therapy are illustrated in terms of their production routes and ease of radiolabeling. Applications in clinical diagnostic and radionuclide therapy are considered, including human studies under clinical trials; their current stages of clinical translations and findings are summarized. Because the metalloid astatine is used for imaging and radionuclide therapy, it is included in this review. In regard to radionuclide therapy, both beta-minus (β−) and alpha (α)-emitting radionuclides are discussed by highlighting their production routes, targeted radiopharmaceuticals, and current clinical translation stage.