Miracle-dz/UniFAR-FTUs huggingface dataset:
DMSO_A_312420 2389..2397

*These authors contributed equally to this work Purpose: Although psoriasis (PsO) is highly associated with insulin resistance (IR), the role of PsO on activity of insulin secretion or its action in diabetic patients has not been explored. Materials and Methods: In-patient data on type 2 diabetes (T2D) with or without PsO from 2016–2019 in our hospital were analyzed. Data for 42 diabetic patients with PsO were compared with that of the control group (T2D only). Blood examinations with reference to the levels of fasting blood glucose, C-peptide, insulin, HbA1c, plasma lipids, lipoproteins, and kidney function were explored. HOMA-IR and HOMA-β models were established to explore IR and pancreatic β-cell function. Results: HOMA-IR level was significantly higher (P=0.0003<0.05) in patients with PsO compared with the controls. Although the durations of diabetes in patients with PsO were significantly shorter compared with that of patients with diabetes only (P=0.012<0.05), analysis of mean BMI, eGFR, plasma lipids, and lipoprotein showed no significant differences. Analysis of the level of fasting glucose and HOMA-β showed no statistical differences between the two groups. On the other hand, the levels of C-peptide of PsO group were significantly high in both fasting state (P=0.0182<0.05) and after glucose challenge (P=0.0011<0.01). Conclusion: The findings of this study show that under the same fasting conditions, patients with PsO may have relatively preserved pancreatic β-cell function, and PsO significantly increases IR.
RRTM_A_248604 73..80

1Department of Microbiology, College of Medicine, Taif University, Taif, Kingdom of Saudi Arabia; 2Department of Microbiology and Immunology, Faculty of Pharmacy, University of Sadat City, Sadat City, Menoufia Governorate, Egypt; 3Division of Pharmaceutical Microbiology, Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif, Kingdom of Saudi Arabia; 4Parasitology Department, Theodor Bilharz Research Institute, Imbaba, Giza, Egypt; 5Department of Microbiology and Biotechnology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt Abstract: Schistosomiasis ranks second behind malaria in terms of overall morbidity and mortality. We evaluated the lethal effect of Punica granatum ellagitannins, extracted from the fruit rind, placenta and barks of the root and stem, on adult worms of Schistosoma mansoni (S. mansoni). All four ellagitannins were lethal to S. mansoni adult worms. However, while the rind ellagitannins were the most potent, placental ellagitannins were the least. Rind ellagitannins were capable of killing 40% of adult worms at a concentration of 25μg/mL after 5 days. The killing of 100% of the worms was achievable by rind ellagitannins at a concentration of 50μg/mL after 5 days. The LD50S of the rind ellagitannins after 96h and 120h were 41.25 μg/mL and 28.73 respectively. Ellagitannins-treated worms suffered from erosions, wrinkles, swellings and losses, degenerations of the surface tubercles and tegument. In addition, ellagitannins induced deformation and degradation of oral and ventral suckers and degenerations in the muscles of worms. Ellagitannins also caused a separation of coupled worms and reduction of their motility. Data obtained suggest that ellagitannins of pomegranate could be considered as a cheap candidate for the treatment of schistosomiasis.
University of Southern Denmark Validation of a commercial and custom made accelerometer-based software for step count and frequency during walking and running

• You may download this work for personal use only. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying this open access version If you believe that this document breaches copyright please contact us providing details and we will investigate your claim. Please direct all enquiries to puresupport@bib.sdu. dk
INTERACTIVE ROLE OF OBESITY INDICES ON BREAST CANCER SEVERITY IN JORDANIAN WOMEN

Background: An estimated 1.7 million new cases of breast cancer (BC) are diagnosed each year in women worldwide. Of these, the majority are categorized as invasive ductal cell carcinoma. The obesity is a public health problem. The evidence that link obesity indices and breast cancer (BC) is highly controversial. Objective: To evaluate the relationship between obesity indices and BC severity and treatment exposure. Methods: A total of 400 BC patients aged 25-65 years attending BC clinics at the Jordanian Royal Medical Services, Jordan were screened for the presence of obesity. The experimental design permitted to include 134 newly-diagnosed BC patients who were not exposed to any type of interventions and 262 recently-diagnosed BC patients (up to three months). Recently group member were sub-divided in two sub-groups to control exposure to chemotherapy. The patients were further divided according to BC stages into early stage and advanced stage as a measurement of BC severity. Pre-and postmenopausal status was also studied. The obesity indices consisted of BMI, WHpR, WHtR and WC. Results: More than 50% of BC patients were obese. The obesity prevalence was decreased when the Jordanian group cut-off points were used. Obesity in advanced stage was more prevalent than early stage. The WC and WHtR were higher in chemo (102.6 ± 1.0 vs. 0.65 ± 0.0 cm) than in newly-diagnosed (99.7 ± 1.1 vs. 0.63 ± 0.0 cm) groups and non-chemo (97.5 ± 1.3 vs. 0.62 ± 0.0 cm). Conclusion: Obesity was prevalent among BC patients and it was increased with BC severity. The burden of obesity on society continues to increase and warrants closer attention by clinicians for both cancer prevention and improved outcomes after diagnosis.
MUCOADHESIVE BUCCAL TABLETS OF NISOLDIPINE FOR ORAL DELIVERY: PREPARATION, IN-VITRO AND IN-VIVO EVALUATION

Nisoldipine (ND) is calcium channel blocker used in treatment of hypertension. ND has poor oral bioavailability (BA) of about 5% due to extensive first-pass metabolism and limits its therapeutic use. Hence, the buccal delivery was considered as an alternative used to enhance the BA of ND. ND buccal tablets (ND-BT) were prepared by direct compression technique, using carbopol 934P HPMC K4M and K15M as muco-adhesive polymers. Prepared ND-BT formulations were evaluated for an optimized system based on physico-chemical, ex-vivo residence time, in-vitro and ex vivo permeation studies. Further, in vivo studies of optimized ND-BT were conducted in pig’s comparison with ND marketed formulation. The evaluation parameters of the tablets were within the pharmacoepial acceptable limits. However, the swelling and bio-adhesive strength were increased with increasing polymer concentrations. From the in-vitro release studies it is shown that, tablets with HPMC K4M (N2) exhibited better release profile than all other formulation, and were considered as optimized BT formulation. The release mechanism from kinetic methods suggests that, the drug release follows zero-order kinetics with diffusion mechanism. Further, about 2.63-folds enhancement in the oral bioavailability of ND from buccal tablet was observed when compared with marketed formulation. Thus, the buccal tablets of ND showed enhanced BA and could be another delivery approach for oral administration.
Young and Reckless: An Analysis of Methods to Reduce Underage Drunk Driving in

Drunk Driving in Merced Underage drinking and driving is a well-studied phenomena in American adolescents. It has become more and more recognized as a legitimate issue. Alcohol-impaired driving contributed to over 12,000 fatalities and an approximate 500,000 years of life lost in the year of 2014, according to one study (Stahre et al. 2014). The CDC reports through the Youth Risk Behavior Survey of 2017 that about 30% of high school students had consumed alcohol in the past month, and 17% had ridden in a car with a driver who had been drinking alcohol. In this paper, I will review existing studies on underage drinking and driving, specifying the data to Merced where applicable. I will discuss why this phenomena occurs, according to the existing literature. I will then discuss and analyze existing models for reducing underage drinking and driving. Finally, I will synthesize the best parts of the existing models into a single model that can be applied to Merced.
FREQUENCY OF PSYCHIATRIC MORBIDITY AMONGST PATIENTS WITH DIABETES MELLITUS IN A MEDICAL OUTPATIENT

The present study was conducted to find the frequency of psychiatric morbidity among diabetes mellitus patients in medical outpatient department. This represents an observational study based on the patients reporting to a hospital OPD. This study lasted for over one month at Combined Military Hospital Nowshera. Patients attending diabetic clinic (n=50) were screened with the General Health Questionnaire. Present State Examination was applied to the positive cases for the consistency of the psychiatric diagnosis. A control group (n = 50) was selected amongst the attendants of the patients and the same instruments were applied. The frequency of psychiatric morbidity was found out along with individual psychiatric diagnoses. 54 % of diabetics had significant psychiatric morbidity. Only 24 % of the control group had psychological problems (p = 0.0038). The common disorders among the diabetics were adjustment disorder, depressive disorder and generalized anxiety disorder. It is concluded that the increased frequency of psychiatric morbidity among the diabetics raises the need for early diagnosis and prompt treatment.
Introductory Chapter: A Comprehensive Approach to the Process of Breastfeeding

Breastfeeding is a fundamental pillar of child nutrition, with important implications for the health welfare due to its impact on morbidity and mortality, especially among children under 1 year of age. Therefore, there is consensus among different organizations dedicated to the health of children about the importance of breast milk as a food of choice during the first 6 months of life, and it is considered a fundamental public health policy. The World Health Organization (WHO) recommends early initiation of breastfeeding within the first hour after birth and exclusive breastfeeding during the first 6 months of life [1]. Recently, the WHO defined the 2025 Global Nutrition Targets aimed at improving maternal, infant, and young child nutrition. Among these, breastfeeding has been prioritized in the fifth target: “increase the rate of exclusive breastfeeding in the first 6 months up to at least 50%” [2].
EFFECTIVENESS OF MUSCLE ENERGY TECHNIQUES (METS) COMPARED TO PASSIVE STRETCHING IN IMPROVING HAMSTRING FLEXIBILITY IN PATIENTS OF NONSPECIFIC CHRONIC LOW BACK PAIN

: Background : Hamstring tightness or decreased flexibility is a predisposing cause for the hamstring strain, lumbar spine disorders, and low back pain. Objective : To determine whether muscle energy technique or static-passive stretch is the better treatment for increasing hamstring flexibility in patients suffering from nonspecific chronic low back pain. Materials and methods : It were a quasi-experimental study which completed in 4 months from November 2016 to February 2017. A total of 60 subjects of chronic nonspecific low back pain who fulfilled inclusion criteria were selected from different hospital settings of Lahore through convenient sampling and allocated into Group A and Group B. After pre-testing through active knee extension test, subjects in Group A were given muscle energy technique along with conventional physiotherapy and subjects in Group B were given static passive stretching along with conventional physiotherapy treatment. Post-test measurements were taken after 4 weeks. The treatment of five sessions a week, for a total of four weeks, was given to both groups. Improvement in hamstring flexibility was measured through active knee extension test. Results: SPSS version 20 was used for analysis. Within groups analysis showed that mean popliteal angle of Group A in pretest measurements was 146.03±12.92 and in posttest measurements was 158.70±9.87 (p<0.001*) and mean popliteal angle of measurements in Group B for pretest readings was 147.30±10.75 and in posttest reading, was 155.67±11.55(p<0.001*) showing significant improvement with both interventions. Mean of difference of pretest-posttest Conclusion : Muscle energy techniques and static passive stretching, both were effective improving the hamstring flexibility but muscle energy techniques found to have better effect as compared to static passive stretching in improving hamstring flexibility in patients with non-specific low back pain Please cite this article in press Shah Zaib Raza et al, Effectiveness Of Muscle Energy Techniques (METS) Compared To Passive Stretching In Improving Hamstring Flexibility In Patients Of Nonspecific Chronic Low Back Pain. , Am. J. P. Sci, 2021; 08(02).
ON THE GROUND STATE OF THE LAPLACIAN WITH A MAGNETIC FIELD CREATED BY A RECTILINEAR CURRENT

We consider the three-dimensional Laplacian with a magnetic field created by an infinite rectilinear current bearing a constant current. The spectrum of the associated hamiltonian is the positive half-axis as the range of an infinity of band functions all decreasing toward 0. We make a precise asymptotics of the band function near the ground energy and we exhibit a semi-classical behavior. We perturb the hamiltonian by an electric potential. Helped by the analysis of the band functions, we show that for slow decaying potential, an infinite number of negative eigenvalues are created whereas only finite number of eigenvalues appears for fast decaying potential. The power-like decaying potential determining the finiteness of the negative spectrum is different than for the free Laplacian.
EMOTIONAL DESIGN THROUGH MEASUREMENT OF PSYCHOPHYSIOLOGICAL AND BEHAVIORAL PARAMETERS: TAKING STEPS TOWARDS NEURODESIGN

There are a number of unknowns regarding conventional Emotional Design methodologies, especially in terms of the feedback from target users. Grey areas include questions such as: why are these methodologies so trusting of the user's response? Does the user really understand what is being asked of them? How do such methodologies consider the external factors that condition the emotional state of the individual, and therefore their answer? Is a subjective analysis of the emotion resulting from the cognitive interpretation of a stimulus sufficient? If it is indeed possible to measure the physiological reﬂex of an emotion, why is this parameter rarely considered as a viable option? The main objective of this investigation is to respond to these questions, thus making the possibility of project development via emotional design more accessible. This can be achieved by leveraging the objectivity of the physiological register through the use of appropriate technology, and by ﬁne-tuning the technical speciﬁcations and product design parameters which relate to the end-user's various needs, in terms of product functionality, usability and the user's emotional involvement.
Effects of a cream containing 5% hyaluronic acid mixed with a bacterial-wall-derived glycoprotein, glycyrretinic acid, piroctone olamine and climbazole on signs, symptoms and skin bacterial microbiota in subjects with seborrheic dermatitis of the face

Objective: A new cream formulation containing hyaluronic acid 5%, complexed with a mix of a bacterial-wall-derived glycoprotein and peptide glycan complex (EDS), has been recently developed. We evaluated in a prospective, assessor-blinded, 6-week study the ef ﬁ cacy and tolerability of EDS in the treatment of facial seborrheic dermatitis (SD) and the effects on skin microbiota. Subjects and methods: Seventy- ﬁ ve subjects (mean age 46; 60 men) with moderate-severe SD of the face were enrolled. EDS cream was applied twice daily. The primary outcome was the evolution of the Investigator Global Assessment (IGA) score, evaluating erythema, scale/ ﬂ aking, grade of seborrhea and itch. Super ﬁ cial skin bacterial microbiome at baseline and after treatment was assessed, using the 16S rRNA gene methodology, in affected and non-affected face areas. Local tolerability was evaluated checking self-reported side effects at each visit. Results: Baseline IGA scores (mean±SD) was 10±3. The use of EDS reduced IGA score signi ﬁ cantly by 70% at week 3 and by 88% at week 6. An increase in the abundance of Cutibacterium acnes genera associated with a signi ﬁ cant drop of Staphylococcus genera presence was detected in affected areas. The ratio of relative abundance of genera Cutibacterium /Staphylococcus increased signi ﬁ cantly after treatment in affected areas. The product was very well tolerated. Conclusion: Treatment with EDS applied twice daily for 6 consecutive weeks was associated with a reduction of the signs and symptoms of SD. Furthermore, after EDS cream treatment, a reequilibrating effect on facial skin microbiota was observed. The product was very well tolerated.
Synthetic amphipathic helical peptides promote lipid efﬂux from cells by an ABCA1-dependent and an ABCA1-independent pathway

In order to examine the necessary structural fea-tures for a protein to promote lipid efﬂux by the ABCA1 transporter, synthetic peptides were tested on ABCA1-trans-fected cells (ABCA1 cells) and on control cells. L-37pA, an L amino acid peptide that contains two class-A amphipathic helices linked by proline, showed a 4-fold increase in cholesterol and phospholipid efﬂux from ABCA1 cells compared to control cells. The same peptide synthesized with a mixture of L and D amino acids was less effective than L-37pA in solubilizing dimyristoyl phosphatidyl choline vesicles and in efﬂuxing lipids. In contrast, the 37pA peptide synthesized with all D amino acids (D-37pA) was as effective as L-37pA. Unlike apoA-I, L-37pA and D-37pA were also capable, although at a reduced rate, of causing lipid efﬂux independent of ABCA1 from control cells, Tangier disease cells, and paraformaldehyde ﬁxed ABCA1 cells. The ability of peptides to bind to cells correlated with their lipid afﬁnity.
Exploitation of phase and vocal excitation modulation features for robust speaker recognition

Speaker recognition (SR) refers to the process of automatically determining or verifying the identity of a person based on his or her voice characteristics. In practical applications, a voice can be used as one of the modalities in a multimodal biometric system, or be the sole medium for identity authentication. The general area of speaker recognition encompasses two fundamental tasks: speaker identification and speaker verification. Mel-frequency cepstral coefficients (MFCCs) are widely adopted in speech recognition as well as speaker recognition applications. They are extracted to primarily characterize the spectral envelope of a quasi-stationary speech segment. It was shown that cepstral features are closely related to the linguistic content of speech. Besides the magnitude-based cepstral features, there are resources in speech, e.g., the phase and excitation source, are believed to contain useful properties for speaker discrimination. Moreover, in real situations, there are large variations exist between the development and application scenarios for a speaker recognition system. These include channel mismatch, recording apparatus mismatch, environmental variation, or even change of emotional/healthy state of speakers. As a consequence, the magnitude-based features are insufficient to provide satisfactory and robust speaker recognition accuracy. Therefore, the exploitation of complementary features with MFCCs may provide one solution to alleviate the deficiency, from a feature-based perspective.
Functional evidence for subfornical organ-intrinsic conversion of angiotensin I to angiotensin II

Functional evidence for subfornical organ-intrinsic conversion of angio- tensin I to angiotensin II. Am. J. Physiol. 276 ( Regulatory Integrative Comp. Physiol. 45): R1630–R1638, 1999. —Using extracellular electrophysiological recording in an in vitro slice preparation, we investigated whether ANG I can be locally converted to the functionally active ANG II within the rat subfornical organ (SFO). ANG I and ANG II (10 2 8 –10 2 7 M) excited , 75% of all neurons tested with both peptides ( n 5 25); the remainder were insensitive. The increase in ﬁring rate and the duration and the latency of the responses of identical neurons, superfused with equimolar concentrations of ANG I and ANG II, were not different. The threshold concentrations of the ANG I- and ANG II-induced excitations were both 10 2 9 M. Inhibition of the angiotensin-converting enzyme by captopril (10 2 4 M; n 5 8) completely blocked the ANG I-induced excitation, a 10-fold lower dose was only effective in two of four neurons. The AT 1 -receptor antagonist losartan (10 2 5 M; n 5 6) abolished the excitation caused by ANG I and ANG II. Subcutaneous injections of equimolar doses ofANG I andANG II (200 µl; 2 3 10 2 4 M) in water-sated rats similarly increased water intake by 2.4 6 0.5 ( n 5 16) and 2.7 6 0.4 ml ( n 5 20) after 1 h, respectively. Control rats receiving saline drank 0.07 6 0.06 ml under these conditions. Pretreatment a low of (2.3 3 10 2 3 M) 10 min before the injection of ANG I caused a water intake of 2.8 6 0.5 ml ( n 5 10), whereas a high dose of captopril (4.6 3 10 2 1 M) suppressed the dipsogenic response of ANG I entirely ( n 5 11). These data provide direct functional evidence for an SFO-intrinsic renin-angiotensin system (RAS) and underline the importance of the SFO as a central nervous interface connecting the peripheral with the central RAS.
TNF-α Regulates Corneal Langerhans Cell Migration

Langerhans cells (LC) belong to the dendritic cell family and mediate Ag presentation in the cornea and ocular surface. Under normal physiological conditions, the central cornea is devoid of LC. Centripetal migration of LC plays a critical role in promoting immunoinflammatory responses in the eye including allograft rejection and herpetic keratitis. The molecular mechanisms responsible for ocular LC migration are poorly understood. To examine whether TNF-α mediates corneal LC migration and to establish the interaction of IL-1 and TNF-α in regulating LC migratory capacity, we utilized gene-targeted knockout mice lacking IL-1 receptor I (IL-1RI−/−), TNF receptor I (p55−/−), TNF receptor II (p75−/−), or both (p55−/−p75−/−). LC migration was induced by thermal cautery or cytokine injection and enumerated by an immunofluorescence assay. Migration of LC after cauterization and TNF-α injection was significantly depressed in both p55−/− and p75−/− mice. Similarly, in the first 72 h after intracorneal injection of IL-1α, LC migration was reduced in p55−/−, p75−/−, and p55−/−p75−/− mice. In contrast, injection of TNF-α in IL-1RI−/− mice led to normal migration of corneal LC indistinguishable from wild-type controls. These results suggest that the IL-1 induction of corneal LC migration is largely mediated by TNFR function, whereas TNF-α induction of LC migration is independent of IL-1RI activity. Moreover, the data suggest that both p55 and p75 signaling pathways are important in mediating LC migration in the cornea.