Miracle-dz/UniFAR-FTUs huggingface dataset:
CMAR_A_345871 9247..9259

1Department of Radiation Oncology, Beijing Geriatric Hospital, Beijing, People’s Republic of China; 2Department of Radiation Oncology, Air Force General Hospital, Beijing, People’s Republic of China Background and Purpose: This study aimed to investigate the efficacy and safety of maintenance therapy combined with local radiotherapy at all oligometastatic sites (LRTOS) in elderly patients with metachronous oligometastatic cancers (MOC). Patients and Methods: A total of 242 elderly patients with MOC (≤5 metastases) and primary tumor well controlled after definitive treatment was retrospectively analyzed between August 2014 and February 2020 at Beijing Geriatric Hospital and Air Force General Hospital. Patients were divided into maintenance therapy group (maintenance therapy alone) and local radiotherapy group (maintenance therapy combined with LRTOS). Results: There were 86 patients in the local radiotherapy group and 156 patients in the maintenance therapy group. The median length of follow-up was 36 months (range, 8.0–62 months). Median overall survival (mOS) was 25 months (95% CI: 21.1–28.9) in the local radiotherapy group and 16 months (95% CI: 14.5–17.6) in the maintenance therapy group (p < 0.001). Multivariate analyses demonstrated that LRTOS (hazard ratio (HR) = 0.49, 95% confidence interval (CI): 0.35– 0.67, p < 0.001), good Eastern Cooperative Oncology Group Performance Status (ECOG PS, HR = 0.69, 95% CI: 0.49–0.97, p = 0.032), longer duration between diagnosis of primary tumor and occurrence of progression (HR = 0.87, 95% CI: 0.78–0.97, p = 0.015), and subsequent systemic treatment (HR = 0.52, 95% CI: 0.38–0.72, p < 0.001) were independent predictors of good OS. In patients who did not receive subsequent systemic treatment, their mOS was 21 months (95% CI: 12.8–29.2) for those treated with LRTOS and 14 months (95% CI: 11.4–16.6) for those who did not receive local radiotherapy (p = 0.001). Further multivariate analysis showed that LRTOS was the only independent factor for predicting good OS (HR = 0.47, 95% CI: 0.26–0.83, p = 0.010). Patients with metachronous oligometastatic lung cancer, colorectal cancer, prostate cancer, and breast cancer had higher survival benefits following LRTOS. Most patients suffered from grade 1–2 toxicities, but no treatment-related death was recorded. Conclusion: This retrospective study shows that elderly patients with MOC treated with LRTOS may have better survival outcomes.
AnEffectiveHeuristic Algorithm based on Segmentation a Multilevel Lot-sizing Problem for Solving

This poper presents an E:fi2? ctive heuristic aigorithm for solving the multilevei lot-sizing problem, vvhich is an itmportant decision making process in mantti2icturing production systems and a weU-known example ofa combinatorial optimizationprohlent. 77ie heuristic aigorithm is hased on the sq17 optimization approach. ft has been rqported recently that this method can, upith high probahility, result in a goodenotcgh solution to the multilevel lot-sizing problem. Sbfar, however, it has proved to be rather inqfiicient. 77iis p[uper develops an aigorithm based on segmentation, which uses the structure ipzformation ofthe lot-sizing problem in samplitzg] so that betterpepfortnance can be achieved 71ie f)2ictiveness ofthe heuristic aigorithm is shown Zp, experiments, which compare the soj7 optimization approach with the senetic aigorithm,
Thermophysical properties of gallic acid in aqueous -cyclodextrin solutions at different temperatures

Density and viscosity measurements of an anti cancer agent, gallic acid in several molal concentrations m = (0.001–0.007) mol.kg–1 of aqueous -cyclodextrin solutions were carried out at T = (298.15–318.15) K and P = 101 kPa. Using experimental data apparent molar volume (V), standard partial molar volume (V), the slope (S*V), standard isobaric partial molar expansibility (E) and its temperature dependence (E/T)P, the viscosity B-coefficient and solvation number (Sn), etc., were determined. Free energies of activation of viscous flow per mole of the solvents (1) and of the solute (2) are also calculated. Various results revealed that the solutions are characterized predominantly by solute-solvent interactions and gallic acid behaves as a long-range structure maker.
PMIPv6-based Inter-Domain Handover using Efficient Buffering Scheme

—Global Handover (HO) requirement between domains is increasingly in demand to provide home network accessibility in remote places. This necessity will lead continuous services between different domains by the Proxy Mobile IPv6 ( PMIPv6)-based mobility. In this paper, we introduce the enhanced inter-domain HO mechanism using the efficient buffering scheme to provide continuous services and buffered data backup mechanism for the data delivery to reduce the inter-domain HO delay between different PMIPv6 domains. The simulation result shows that the efficient buffering scheme and the buffered data backup mechanism deliver buffered data among the different domains right after completion of inter-domain handover.
Channel Estimation for Massive MIMO Systems

Abstract: In MIMO millimeter-wave (mmWave) systems, while the hybrid digital/analog precoding structure provides the ability to increase the reach rate, it also faces the challenge of reducing the channel time limit due to the large number of horns on both sides of the Tx / Rx. In this paper, channel measurement is done by searching with multiple beams, and a new hierarchical multi-beam search system is proposed, using a pre-designed analog codebook. Performance tests show that, compared to a highperformance system, the proposed system not only achieves a high level of success in getting multiple beams under normal system settings but also significantly reduces channel estimation time Keywords: Massive MIMO, Channel Estimation, precoding
Title The effects of smoke-free legislation on acute myocardial infarction: A systematic review and meta-analysis

Background: Comprehensive smoke-free legislation has been implemented in many countries. The current study quantitatively examined the reduction in risk of acute myocardial infarction (MI) occurrence following the legislations and the relationship with the corresponding smoking prevalence decrease. Methods: PubMed, EMBASE, and Google Scholar databases and bibliographies of relevant studies and reviews were searched for potential original studies published from January 1, 2004, through October 31, 2011. Meta-analysis was performed using a random effect model to estimate the overall effects of the smoking-free legislations. Meta-regression was used to investigate possible causes of heterogeneity in risk estimates. Results: A total of 18 eligible studies with 44 estimates of effect size were used in this study. Meta-analysis produced a pooled estimate of the relative risk of 0.87 (95% confidence interval (CI): 0.84 to 0.91). There was significant heterogeneity in the risk estimates (overall I = 96.03%, p<0.001). In meta-regression analysis, studies with greater smoking prevalence decrease produced larger relative risk (adjusted coefficient −0.027, 95% CI: -0.049 to −0.006, p=0.014). Conclusion: Smoke-free legislations in public and work places were associated with significant reduction in acute MI risk, which might be partly attributable to reduced smoking prevalence.
Review A Framework for Stormwater Quality Modelling under the Effects of Climate Change to Enhance

Water scarcity, which is exacerbated by climate change, is a major challenge to ensure human well‐being. Therefore, it is equally important to protect conventional water resources from degradation and at the same time to identify cost‐effective alternatives with a low carbon footprint. In this regard, stormwater plays a key role as it is a largely underutilised resource for both potable and non‐potable use. However, stormwater carries substantial loads of pollutants to receiving waters such as rivers. Unfortunately, the lack of comprehensive stormwater quality modelling strategies, which account for the effects of climate change, constrains the formulation of effective measures to improve the quality of stormwater. Currently, there is a significant knowledge gap in the merging of stormwater quality modelling and climate modelling. This paper critically reviews current stormwater quality modelling approaches (quantity and quality) and the role of climate modelling outputs in stormwater quality modelling. This is followed by the presentation of a robust framework to integrate the impacts of climate change with stormwater quality models.
DODAX :MO nanocarriers toxicity in vitro and in vivo†

Liposomes have received extensive attention as nanocarriers for bioactive compounds due to their good biocompatibility, possibility of targeting and incorporation of hydrophilic and hydrophobic compounds. Although generally considered as safe, detailed knowledge of the effects induced in cells and tissues with which they interact is still underexplored. The aim of this study is to gain insight into the toxicity profile of dioctadecyldimethylammonium (DODAX) : monoolein(MO) liposomes (X is bromide or chloride), previously validated for gene therapy, by evaluating the effect of the counter ions Br or Cl, and of the cationic : neutral lipid molar fraction, both in vitro and in vivo. Effects on cellular metabolism and proliferation, plasma membrane integrity, oxidative stress, mitochondrial membrane potential dysfunction and ability to trigger apoptosis and necrosis were evaluated in a dose-/time-dependent manner in normal human skin fibroblasts. Also, newly fertilized zebrafish zygotes were exposed to liposomes, permitting a fast-track evaluation of the morphophysiological modifications. In vitro data showed that only very high doses of DODAX : MO induce apoptosis and necrosis, inhibit cell proliferation, and affect the metabolism and plasma membrane integrity of fibroblasts in a dose-/time-dependent manner. Furthermore, liposomes affected mitochondrial function, increasing ROS accumulation and disturbing mitochondrial membrane potential. DODAC-based liposomes were consistently more toxic when compared to DODABbased formulations; furthermore, the inclusion of MO was found to reduce toxicity, in contrast to liposomes with cationic DODAX only, especially in DODAB : MO (1 : 2) nanocarriers. These results were corroborated, in a holistic approach, by cytotoxicity profiling in five additional human cell lines, and also with the zebrafish embryotoxicity testing, which constitutes a sensitive and informative tool and accurately extends cell-based assays.
Nerlich, Brigitte and Koteyko, Nelya (2009) Compounds, creativity and complexity in climate change communication: the case of ‘carbon indulgences’. Global

This article deals with climate change from a linguistic perspective. Climate change is an extremely complex issue that has exercised the minds of experts and policy makers with renewed urgency in recent years. It has prompted an explosion of writing in the media, on the internet and in the domain of popular science and literature, as well as a proliferation of new compounds around the word „carbon‟ as a hub, such as „carbon indulgence‟, a new compound that will be studied in this article. Through a linguistic analysis of lexical and discourse formations around such „carbon compounds‟ we aim to contribute to a broader understanding of the meaning of climate change. Carbon compounds are used here as indicators for observing how human symbolic cultures change and adapt in response to environmental threats and how symbolic innovation and transmission occurs.
INCIDENCE OF KNEE OSTEOARTHRITIS IN OBESE ADULTS

Background: Obesity is considered as significant independent risk factor for knee osteoarthritis. It is estimated that force of nearly 3 to 6 times one’s body weight is exerted across knee joint. Waist Hip Ratio is the good indicator of visceral fat, the waist hip ratio greater than 0.9 in females and greater than 0.8 in male’s increases excessive load on the knee joint which alters the Q-angle. The Western Ontario And McMaster Universities Osteoarthritis Index scale was used as an outcome measure to assess pain, stiffness, and physical function in patients with hip and knee osteoarthritis. Objective: To find out the early osteoarthritis knee in obese adults and effect of high hip waist ratio on Q-angle and its relation with osteoarthritis knee. Method: 50 subjects including male and female were included in this study with age between 35-45 years and classified into into 2 groups symptomatic and non-symptomatic Patients were clinically assessed for functional status by using Western Ontario And McMaster Universities Osteoarthritis Index scale. Result: The incidence of Osteoarthritis knee was found more in age group ranging from 41-45years and was greater in female population. The symptomatic patients were greater in obese class 2 and 3 with mean of 33.36±4.038. Q-angle was taken with mean deviation of 15.9±2.119 for male and 19.9±2.119 for female. Out of 30 symptomatic patients, 17 patients presented with WOMAC score between 20-40%. Conclusion: In this study, we concluded that incidence of osteoarthritis knee was found greater between age group 41-45years with female population more than male population.
CrossBit: A Multi-Sources and Multi-Targets DBT

—Dynamic binary translator (DBT) is typically used for software migration or binary code optimization. In this paper, we describe the design and implementation of a multi-sources and multi-targets DBT–CrossBit, which aims at fast migrating existing executable source code from one platform to another alien target platform with lower cost. In order to support code translation among multi-sources and multi-targets better, a new intermediate instruction set– VInst, which is independent of any speciﬁc machine instructions, has been introduced. Unlike many other existing DBTs which directly translate the binary code of one instruction set architecture (ISA) to another ISA, CrossBit ﬁrst converts source binary code to VInst speciﬁcations, and then transforms them into target platform code, using a granularity of a basic block (BB) as the unit of translation. Additionally, to address the performance issue, we adopt several generic optimization methods to optimize the translated code. Finally, our experimental result indicates that, for the SPECint2000 benchmarks, CrossBit’s performance is pleasant and can meet the design requirement.
Heat Transfer Enhancement in A Corrugated-Trapezoidal Channel Using Winglet Vortex Generators

1 Aerodynamic, Heat Transfer & Propulsion Group, Department of Aerospace Engineering, Universiti Putra Malaysia, 43400 Serdang, Selangor Malaysia 2 Aerospace Malaysia Research Centre, Faculty of Engineering, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia 3 Department of Mechanical and Manufacturing Engineering, Universiti Putra Malaysia, 43400 Serdang, Selangor Malaysia 4 Department of Mechanical Engineering, Universiti Tenaga Nasional, 43000 Kajang, Selangor, Malaysia
Characterization and Phytochemical Property of Okra Fruits

The Okra crop is of significant nutritional value. It contains a high percentage of water, averaging 85%, total fat of 0.5%, protein content of 4% and 5.4% carbohydrate. The carbohydrate is present as cellulose, starch in small quantity and sugar. It also contains non-cellulose, non-starch, polysaccharides. Proteins play a particularly important role in human nutrition. Determination of okra for qualitative and quantitative phytochemicals properties and characterization of its mucilage were conducted using standard methods. The results of the characterization showed: Solubility (sparingly soluble in water and insoluble in acetone and ethanol), pH (6.9±0.22), viscosity (245.58±0.03) and swelling ratio (3.4±0.03). Phytochemical screening revealed the presence of Tannins, Steroids, Flavonoids, Saponins, Alkaloids, Anthraquinones, Phenol, Terpenoids, Cardiac Glycosides and Cardenoids. Quantitatively okra contained (%) Flavanoids (12.54), Saponins (18.33) and Alkaloids (10.53) while the estimated quantity of aqueous and ethanolic extracts are 17.43 and 14.65%. The presence of phytochemical in the okra suggests possible preventive and curative property of the lemon grass. Medically, the presence of these phytochemicals explains the use of the plant in ethno-medicine for the management of various ailments.
Differentiation of Hanwoo Beef Cattle Intramuscular Stromal Vascular Cells Treated with Different Concentrations of Calcium and Retinoic Acid

Marbling, or intramuscular fat, has been consistently identified as one of the top beef quality problems. Intramuscular adipocytes distribute throughout the perimysial connective tissue of skeletal muscle and are the major site for the deposition of intramuscular fat, which is essential for the eating quality of meat. The stromal vascular fraction of the skeletal muscle contains progenitor cells that can be enhanced to differentiate to adipocytes and increase intramuscular fat. Primary cultures of bovine intramuscular stromal vascular cells were used in this study to elucidate the effects of extracellular calcium and retinoic acid concentration on adipocyte differentiation. Cell viability assay revealed that even at different concentrations of calcium and retinoic acid, there was no significant difference on cell viability. Monitoring of the adipocyte differentiation showed that bovine intramuscular stromal vascular cells cultured in low concentration of extracellular calcium and retinoic acid had better degree of fat accumulation. The mRNA and protein expressions of PPARγ, C/EBPα, SREBP-1c and aP2 were analyzed and showed a significant upregulation upon the reduction in the level of extracellular calcium and retinoic acid. The upregulation of these adipogenic related genes means that the decreasing concentration of calcium and retinoic acid is able to stimulate the adipogenic differentiation of bovine intramuscular stromal vascular cells. To further elucidate the effect of calcium, the expression level of calreticulin was measured. Calreticulin which is known to be an inhibitor of PPARγ was down regulated by the decreased level of calcium and retinoic acid in the culture media. The same tendency was observed on retinoic acid receptors RARα and CRABP-II. These receptors are recognized as adipogenic inhibitors; and the down regulation of their expression allowed better level of differentiation in bovine intramuscular stromal vascular cells.
Triguero, Isaac and Vens, Celine (2016) Labelling strategies for hierarchical multi-label classification techniques. Pattern Recognition, 56 . pp. 170-183. ISSN 0031-3203

Many hierarchical multi-label classiﬁcation systems predict a real valued score for every (instance, class) couple, with a higher score reﬂecting more conﬁdence that the instance belongs to that class. These classiﬁers leave the conversion of these scores to an actual label set to the user, who applies a cut-oﬀ value to the scores. The predictive performance of these classiﬁers is usually evaluated using threshold independent measures like precision-recall curves. However, several applications require actual label sets, and thus an automatic labelling strategy.
On the Performance Isolation Across Virtual Network Adapters in Xen

—Virtualization has recently become a very popular technique for utilizing hardware capabilities and lowering infrastructure and maintenance costs. However, making several virtual machines share the same resources can potentially introduce performance isolation problems. Depending on the application, proper quality of service and the performance isolation may present critical requirements for the system. In this paper, we focus on network performance isolation among virtual adapters in Xen. We present several experiments demonstrating how activity of one virtual machine can affect the network performance of any other. Additionally, we examine the network I/O scheduler in Xen to see if it is fair, predictable and conﬁgurable enough. Finally, we propose an idea on how to modify Xen back-end drivers to improve the network performance isolation.
CMAR_A_201335 5425..5435

Wei-Xian Chen Ling-Yun Xu Lin Cheng Qi Qian Xiao He Wen-Ting Peng Yu-Lan Zhu 1Department of Breast Surgery, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou 213000, People’s Republic of China; 2Department of Post-doctoral Working Station, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou 213000, People’s Republic of China Background: Resistance to docetaxel is a major obstacle to effective treatment of breast cancer. Exosomal microRNAs (miRNAs) have recently been introduced in cell-to-cell transmission of chemoresistance between heterogeneous populations of tumor cells with diverse drug sensitivity. However, a systematic evaluation of the exosomal miRNA signature remains largely unclear. Method: miRNA expression profiles in exosomes from docetaxel-resistant (D/exo) and parental sensitive breast cancer cells (S/exo) were assessed using microarray. Bioinformatics analysis was performed to predict target genes of the dysregulated miRNAs and to uncover their potential roles in chemoresistance formation. Signaling pathways, gene ontology terms, transcription factors, protein–protein interactions, and hub genes were also constructed. Results: The selected exosomal miRNAs could modulate target genes responsible for MAPK, TGF-beta, Wnt, mTOR, and PI3K/Akt signaling pathways. Function enrichment analysis revealed the involvement of target genes in transcription regulation, protein phosphorylation, kinase activity, and protein binding. Enriched transcription factors including SP1, SP4, and EGR1 were obtained and a protein–protein interaction network was established. The hub genes for up-expressed and down-expressed exosomal miRNAs such as CCND1 and PTEN were identified. Conclusion: This bioinformatics study provides a comprehensive view of the function of dysregulated exosomal miRNAs, and may help us to understand exosome-mediated resistance transmission and overcome docetaxel resistance in future breast cancer therapy.
a strongly

We investigate the dynamics of single- and multi-photon emission from detuned strongly coupled systems based on the quantum-dot-photonic-crystal resonator platform. Transmitting light through such systems can generate a range of non-classical states of light with tunable photon counting statistics due to the nonlinear ladder of hybridized light-matter states. By controlling the detuning between emitter and resonator, the transmission can be tuned to strongly enhance either single-or two-photon emission processes. Despite the strongly-dissipative nature of these systems, we ﬁnd that by utilizing a self-homodyne interference technique combined with frequency-ﬁltering we are able to ﬁnd a strong two-photon component of the emission in the multi-photon regime. In order to explain our correlation measurements, we propose rate equation models that capture the dominant processes of emission both in the single- and multi-photon regimes. These models are then supported by quantum-optical simulations that fully capture the frequency ﬁltering of emission from our solid-state system.