Miracle-dz/UniFAR-FTUs huggingface dataset:
The First Systematic Multi-wavelength Survey of Extragalactic Supernova Remnants

Abstract We present the largest sample of multi-wavelength Supernova Remnants (SNRs) in six nearby galaxies, based on Chandra archival data and deep optical narrow-band Hα and [Sii] images as well as spectroscopic observations. We have identified 37 X-ray selected thermal SNRs, 30 of which are new identifications and ~ 400 optical SNRs, for 67 of which we spectroscopically verified their shock-excited nature. We discuss the properties of the X-ray/optically detected SNRs in different types of galaxies and hence different environments, in order to address their dependence on their Interstellar Medium (ISM). We also discuss the SNR populations in the context of the star formation rate of their host galaxies. We cross-correlate parameters of the optically detected SNRs with parameters of coincident X-ray emitting SNRs in order to understand their evolution and investigate possible selection effects.
Revealing Excited State Trajectories on Potential Energy Surfaces with Atomic Resolution in Real Time.

Photoexcited molecular trajectories on the potential energy surfaces prior to thermalization are intimately connected to the photochemical reaction outcome. The excited state trajectories of a diplatinum complex featuring photo-activated metal-metal 𝜎-bond formation and associated Pt-Pt stretching motions were detected in real time using femtosecond wide angle X-ray solution scattering. The observed motions correspond well with coherent vibrational wavepacket motions detected by femtosecond optical transient absorption. Two key coordinates for intersystem crossing have been identified, the Pt-Pt bond distance and the orientation of the ligands coordinated with the platinum centers, along which the excited state trajectories can be projected onto the calculated potential energy surfaces of the excited states. This investigation has gleaned novel insight into electronic transitions occurring on the time scales of vibrational motions measured in real time, revealing ultrafast nonadiabatic or non-equilibrium processes along excited state trajectories involving multiple excited state potential energy surfaces.
Clinical features and treatment effect of HIV-associated immune thrombocytopenia—single center Ten-Years data summary

Abstract Thrombocytopenia represents one of the most prevalent hematologic complications observed in patients infected with the human immunodeficiency virus (HIV). In this study, we sought to analyze the clinical characteristics and treatment outcomes of patients with coexisting HIV and thrombocytopenia. Specifically, we retrospectively examined the medical records of 45 patients diagnosed with HIV/AIDS and thrombocytopenia at the Yunnan Infectious Diseases Specialist Hospital between January 2010 and December 2020, all of whom received highly active antiretroviral therapy (HAART) with/without glucocorticoids. The median follow-up period was 79 days, ranging between 14 and 368 days, the total platelet count was higher after receiving treatment than before (Z = −5.662, P < .001). Among the cohort, 27 patients (60.0%) responded to treatment, with 12 patients (44.44%) experiencing relapse during the follow-up period. The response rate (80.00%) of newly diagnosed ITP were significantly higher than of persistent ITP (28.57%) and chronic ITP (38.46%) ($${\x}$$\x 2 = 9.560, P = .008) and the relapse rate of the newly diagnosed ITP (30.00%) was significantly lower than the persistent ITP and chronic ITP (100.00%, 80.00%) ($${\x}$$\x2 = 6.750, P = .034). Notably, we found that the number of CD4+ T cells, duration of HIV infection, selection of HAART and type of glucocorticoids administered displayed no statistically significant effect on platelet count, treatment response, or relapse rate. However, we observed a significant decrease in platelet count in hepatitis C virus-positive individuals coinfected with HIV compared to those with HIV alone (Z = −2.855, P = .003). Our findings suggest that patients diagnosed with HIV and thrombocytopenia exhibit a low response rate to treatment and have an increased likelihood of relapse.
Pain Management Interventions for the Treatment of Chronic Low Back Pain

Objective: Determine the relative effectiveness and safety profiles of percutaneous and minimally invasive interventions for chronic low back pain. Methods: A systematic search was performed for randomized controlled trials published in the past 20 years reporting on radiofrequency ablation of the basivertebral, disk annulus and facet nerve structures, steroid injection of the disk, facet joint, and medial branch, biological therapies, and multifidus muscle stimulation. Outcomes evaluated included Visual Analog Scale (VAS) pain scores, Oswestry Disability Index (ODI) scores, quality of life (SF-36 and EQ-5D) scores, and serious adverse event (SAE) rates. Basivertebral nerve (BVN) ablation was chosen as the subject of comparison to all other therapies using a random-effects meta-analysis. Results: Twenty-seven studies were included. BVN ablation was found to provide statistically significant improvements in VAS and ODI scores for 6-, 12- and 24-month follow-up (P≤0.05). Biological therapy and multifidus muscle stimulation were the only 2 treatments with both VAS and ODI outcomes not significantly different from BVN ablation at 6-, 12-, and 24-month follow-up. All outcomes found to be statistically significant represented inferior results to those of BVN ablation. Insufficient data precluded meaningful comparisons of SF-36 and EQ-5D scores. The SAE rates for all therapies and all reported time points were not significantly different from BVN ablation except for biological therapy and multifidus muscle stimulation at the 6-month follow-up. Conclusions: BVN ablation, biological therapy, and multifidus stimulation all provide significant, durable improvements in both pain and disability compared with other interventions, which provided only short-term pain relief. Studies on BVN ablation reported no SAEs, a significantly better result than for studies of biological therapy and multifidus stimulation.
A modified architecture of a perovskite solar cell with an enhanced optical absorption in the visible spectrum

The incomplete absorption of light in the perovskite solar cells (PSCs) due to the escape of photons and the waste of their energy in the visible spectrum hinders the efficiency of this type of solar cell. Utilizing light-trapping nanostructures and stimulating the device’s plasmonic is an efficient way to increase absorption and reduce the energy losses. In this paper, a novel configuration of a nanostructured PSC with a plasmonic enhancement has been introduced to confine light in the active layer and boost energy harvesting. According to the conducted calculations, the modified configuration supports 23.4% higher short-circuit current density (J SC) and 21% power conversion efficiency compared to the conventional PSC. In this study, the finite element method has been employed to perform numerical simulations of the examined structures. For modeling and characterizing solar cells, optical physics of the devices is used in conjunction with their electrical physics.
Correlation between spasticity and corticospinal/corticoreticular tract status in stroke patients after early stage

We investigated the correlation between spasticity and the states of the corticospinal tract (CST) and corticoreticular tract (CRT) in stroke patients after early stage. Thirty-eight stroke patients and 26 healthy control subjects were recruited. The modified Ashworth scale (MAS) scale after the early stage (more than 1 month after onset) was used to determine the spasticity state of the stroke patients. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), fiber number (FN), and ipsilesional/contra-lesional ratios for diffusion tensor tractography (DTT) parameters of the CST and CRT after the early stage were measured in both ipsi- and contra-lesional hemispheres. This study was conducted retrospectively. The FA and FN CST-ratios in the patient group were significantly lower than those of the control group (P < .05), except for the ADC CST-ratio (P > .05). Regarding the DTT parameters of the CRT-ratio, the patient group FN value was significantly lower than that of the control group (P < .05), whereas the FA and ADC CRT-ratios did not show significant differences between the patient and control groups (P > .05). MAS scores showed a strong positive correlation with the ADC CRT-ratio (P < .05) and a moderate negative correlation with the FN CRT-ratio (P < .05). We observed that the injury severities of the CST and CRT were related to spasticity severity in chronic stroke patients; moreover, compared to the CST, CRT status was more closely related to spasticity severity.
Identification of LncRNA-miRNA-mRNA ceRNA network in hypoxia-induced HTR-8/SVneo cells for preeclampsia

Preeclampsia (PE) is a common pregnancy complication, and placental hypoxia is one of its causes. We aimed to identify the transcriptional profile and construct a long non-coding RNAs (lncRNA)-centered competing endogenous RNAs (ceRNA) network in hypoxia-induced HTR8/SVneo cells. We used datasets from the GEO database to identify important pathways in PE. We performed microarray profiling and functional analysis to identify differentially expressed long non-coding RNAs (lncRNAs), differentially expressed profiles of microRNA (miRNAs), and differentially expressed profiles of messenger RNA (mRNAs) in hypoxia-induced HTR8/SVneo cells. The candidates were validated using quantitative reverse transcription polymerase chain reaction. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes analyses were performed to understand the functional significance of differentially expressed genes. Finally, we constructed an lncRNA-centered ceRNA network. Several hub genes were validated both in placentas from PE and normal pregnancy, and in hypoxia-induced HTR8/SVneo cells. The hypoxic response pathway was involved in the pathophysiology of PE. Subsequently, we identified 536 differentially expressed profiles of lncRNAs (183 upregulated and 353 downregulated), 46 differentially expressed profiles of miRNAs (35 upregulated and 11 downregulated), and 2782 differentially expressed profiles of mRNAs (DEmRNAs) (1031 upregulated and 1751 downregulated) in hypoxia-induced HTR8/SVneo cells. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses revealed potential pathways affected by these genes, such as angiogenesis, the HIF-1 signaling pathway, and the PI3K-Akt signaling pathway. The ceRNA network comprised 35 lncRNAs, 11 miRNAs, 27 mRNAs, and 2 hub lncRNAs, which might play a vital role in placental functions and PE. Our results revealed the transcriptome profile and constructed an lncRNA-centered ceRNA network in hypoxia-induced HTR8/SVneo cells, thereby providing potential therapeutic targets for PE.
Erythema multiforme‐like allergic contact dermatitis from bay leaves in a home‐made natural remedy

Dermatology Department, University Hospital of Guadalajara, Guadalajara, Spain Pathology Department, University Hospital of Guadalajara, Guadalajara, Spain Dermatology Department, Toledo Hospital Complex, Toledo, Spain Universidad de Castilla-La-Mancha, Castilla–La Mancha, Spain Dermatology Department, Hospital Universitario Fundaci on Jiménez Díaz, Madrid, Spain Facultad de Medicina y Ciencias de la Salud, Universidad de Alcalá, Alcalá de Henares, Spain
Tetrasporophytic bias coupled with heterozygote deficiency in Antarctic Plocamium sp. (Florideophyceae, Rhodophyta)

Meiosis and syngamy generate an alternation between two ploidy stages, but the timing of these two processes varies widely across taxa, thereby generating life cycle diversity. One hypothesis suggests that life cycles with long‐lived haploid stages are correlated with selfing, asexual reproduction, or both. Though mostly studied in angiosperms, selfing and asexual reproduction are often associated with marginal habitats. Yet, in haploid‐diploid macroalgae, these two reproductive modes have subtle but unique consequences whereby predictions from angiosperms may not apply. Along the western Antarctic Peninsula, there is a thriving macroalgal community, providing an opportunity to explore reproductive system variation in haploid‐diploid macroalgae at high latitudes where endemism is common. Plocamium sp. is a widespread and abundant red macroalga observed within this ecosystem. We sampled 12 sites during the 2017 and 2018 field seasons and used 10 microsatellite loci to describe the reproductive system. Overall genotypic richness and evenness were high, suggesting sexual reproduction. Eight sites were dominated by tetrasporophytes, but there was strong heterozygote deficiency, suggesting intergametophytic selfing. We observed slight differences in the prevailing reproductive mode among sites, possibly due to local conditions (e.g., disturbance) that may contribute to site‐specific variation. It remains to be determined whether high levels of selfing are characteristic of macroalgae more generally at high latitudes, due to the haploid‐diploid life cycle, or both. Further investigations of algal life cycles will likely reveal the processes underlying the maintenance of sexual reproduction more broadly across eukaryotes, but more studies of natural populations are required.
Adaptive robust control for a class of uncertain non-affine nonlinear system

An adaptive robust control law is proposed for a class of uncertain non-affine nonlinear system with unknown structure, parameters and control direction. The non-affine system is first transformed into a time-varying system with a linear structure by using the mean value theory; and then, the bounded time-varying parameters are estimated by adaptive algorithms with projection. The estimation error and external disturbance are compensated by employing nonlinear damping terms. By combining dynamic surface control(DSC) with backstepping technique, and employing Nussbaum gain approach, the designed algorithm eliminates not only the "complexity explosion" problem inherent to the backstepping method, but also the possible "controller singularity" problem causing by unknown control direction. Finally, based on Lyapunov stability theorem and decoupled backstepping method, the semi-global stability of the close-loop system is proved. The simulation results demonstrate the feasibility and validity of the proposed control schemes.
Led-Seq: ligation-enhanced double-end sequence-based structure analysis of RNA

Abstract Structural analysis of RNA is an important and versatile tool to investigate the function of this type of molecules in the cell as well as in vitro. Several robust and reliable procedures are available, relying on chemical modification inducing RT stops or nucleotide misincorporations during reverse transcription. Others are based on cleavage reactions and RT stop signals. However, these methods address only one side of the RT stop or misincorporation position. Here, we describe Led-Seq, a new approach based on lead-induced cleavage of unpaired RNA positions, where both resulting cleavage products are investigated. The RNA fragments carrying 2′, 3′-cyclic phosphate or 5′-OH ends are selectively ligated to oligonucleotide adapters by specific RNA ligases. In a deep sequencing analysis, the cleavage sites are identified as ligation positions, avoiding possible false positive signals based on premature RT stops. With a benchmark set of transcripts in Escherichia coli, we show that Led-Seq is an improved and reliable approach based on metal ion-induced phosphodiester hydrolysis to investigate RNA structures in vivo.
Validation of an ELISA kit to measure allopregnanolone in human and equine hair

In humans, allopregnanolone plays important roles in a number of different neurodegenerative disorders, and it has been proposed for use in some therapies. Horses are commonly used as animal models for human neurodegenerative diseases, mental and behavioral disorders, and neuropsychiatric disorders, and there is interest in using hair as a biological sample to study hormones in these conditions. We validated the use of a commercial ELISA kit (DetectX allopregnanolone kit; Arbor Assays), which was designed for serum, plasma, feces, urine, and tissue samples, to assess allopregnanolone in hair samples from 30 humans and 63 horses. The ELISA kit had good precision (intra- and inter-assay CVs: 6.4% and 11.0% for equine hair; 7.3% and 11.0% for human hair, respectively), sensitivity (50.4 pg/mL for both equine and human hair), and accuracy (parallelism and recovery tests) in determining allopregnanolone concentrations in hair from both species. The allopregnanolone concentrations in human hair were 7.3–79.1 pg/mg; the concentrations were 286 ± 141 pg/mg (x̄ ± SD) in mares on the day of parturition and 16.9 ± 5.5 pg/mg in nonpregnant mares. The DetectX ELISA kit offered a simple and accessible analysis of allopregnanolone in human and equine hair samples.
Inappropriate Shock Delivery Is Common During Pediatric In-Hospital Cardiac Arrest

OBJECTIVES: To characterize inappropriate shock delivery during pediatric in-hospital cardiac arrest (IHCA). DESIGN: Retrospective cohort study. SETTING: An international pediatric cardiac arrest quality improvement collaborative Pediatric Resuscitation Quality [pediRES-Q]. PATIENTS: All IHCA events from 2015 to 2020 from the pediRES-Q Collaborative for which shock and electrocardiogram waveform data were available. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We analyzed 418 shocks delivered during 159 cardiac arrest events, with 381 shocks during 158 events at 28 sites remaining after excluding undecipherable rhythms. We classified shocks as: 1) appropriate (ventricular fibrillation [VF] or wide complex ≥ 150/min); 2) indeterminate (narrow complex ≥ 150/min or wide complex 100–149/min); or 3) inappropriate (asystole, sinus, narrow complex < 150/min, or wide complex < 100/min) based on the rhythm immediately preceding shock delivery. Of delivered shocks, 57% were delivered appropriately for VF or wide complex rhythms with a rate greater than or equal to 150/min. Thirteen percent were classified as indeterminate. Thirty percent were delivered inappropriately for asystole (6.8%), sinus (3.1%), narrow complex less than 150/min (11%), or wide complex less than 100/min (8.9%) rhythms. Eighty-eight percent of all shocks were delivered in ICUs or emergency departments, and 30% of those were delivered inappropriately. CONCLUSIONS: The rate of inappropriate shock delivery for pediatric IHCA in this international cohort is at least 30%, with 23% delivered to an organized electrical rhythm, identifying opportunity for improvement in rhythm identification training.
Timing design for geosynchronous SAR

Compared with low-earth-orbit synthetic aperture radar (SAR), geosynchronous SAR (GEO SAR) due to the long synthetic aperture time and the sensitive effect of the earth's rotation, has great range migration in its echo and the extension of the receiving time window, resulting in the conventional timing design unusable. To solve this problem, a timing design method for GEO SAR is proposed in which the range migration is taken into consideration to avoid loss of echo. The equations and steps of the timing design are given in detail and in addition the range ambiguity and the azimuth ambiguity for GEO SAR are also discussed. Simulated results have verified the validity of the proposed timing design method for GEO SAR.
The Roles of Synchronicity in Distance Education in Japan: The Case of Open University of Japan

Though distance education has a long history, the COVID-19 pandemic has provided us with the opportunity to reexamine the roles of synchronicity in distance education. In Japan, distance education has been practiced mainly in an asynchronous format, originating in the “lecture notes” and subsequent “correspondence education. ” In this paper, the case of the Open University of Japan (OUJ), a sole distance education university with a fully functional broadcast station, is discussed in examining the importance of synchronicity in distance education, where online synchronicity as a pedagogical tool was first introduced as the result of the urgent needs of replacing the face-to-face schooling cancelled due to the COVID-19 pandemic. The results of three surveys conducted after the emergency online classes in July 2020, and synchronous online classes offered in the second semester of 2021 and in the first semester of 2022, show that synchronicity is important for student engagement through interaction and a sense of presence though some students do not like the time bounding aspect of synchronicity; hence causing the synchronicity dilemma.
DeepPvisit: A Deep Survival Model for Notification Management

Notification is a core feature of mobile applications. They inform users about a variety of events happening in the communities. Users may take immediate action to visit the app or ignore the notifications depending on the timing and the relevance of a notification to the user. In this paper, we present the design, implementation, and evaluation of DeepPvisit, a novel probabilistic deep learning survival method for modeling interactions between a user visit and a mobile notification decision, targeting notification volume and delivery time optimization, and driving long-term user engagements. Offline evaluations and online A/B test experiments show DeepPvisit outperforms the existing survival regression model and the other baseline models and delivers better business metrics online.
Cultural Differences in Signed Ego Networks on Twitter: An Investigatory Analysis

Human social behaviour has been observed to adhere to certain structures. One such structure, the Ego Network Model (ENM), has been found almost ubiquitously in human society. Recently, this model has been extended to include signed connections. While the unsigned ENM has been rigorously observed for decades, the signed version is still somewhat novel and lacks the same breadth of observation. Therefore, the main aim of this paper is to examine this signed structure across various categories of individuals from a swathe of culturally distinct regions. Minor differences in the distribution of signs across the SENM can be observed between cultures. However, these can be overwhelmed when the network is centred around a specific topic. Indeed, users who are engaged with specific themes display higher levels of negativity in their networks. This effect is further supported by a significant negative correlation between the number of "general" topics discussed in a network and that network’s percentage of negative connections. These findings suggest that the negativity of communications and relationships on Twitter are very dependent on the topics being discussed and, furthermore, these relationships are more likely to be negative when they are based around a specific topic.