Miracle-dz/UniFAR-FTUs huggingface dataset:
Homoharringtonine-Based Induction Regimen Improved the Remission Rate and Survival Rate in Chinese Childhood AML: A Report From the CCLG-AML 2015 Protocol Study

PURPOSE Homoharringtonine (HHT) is commonly used for the treatment of Chinese adult AML, and all-trans retinoic acid (ATRA) has been verified in acute promyelocytic leukemia (APL). However, the efficacy and safety of HHT-based induction therapy have not been confirmed for childhood AML, and ATRA-based treatment has not been evaluated among patients with non-APL AML. PATIENTS AND METHODS This open-label, multicenter, randomized Chinese Children's Leukemia Group-AML 2015 study was performed across 35 centers in China. Patients with newly diagnosed childhood AML were first randomly assigned to receive an HHT-based (H arm) or etoposide-based (E arm) induction regimen and then randomly allocated to receive cytarabine-based (AC arm) or ATRA-based (AT arm) maintenance therapy. The primary end points were the complete remission (CR) rate after induction therapy, and the secondary end points were the overall survival (OS) and event-free survival (EFS) at 3 years. RESULTS We enrolled 1,258 patients, of whom 1,253 were included in the intent-to-treat analysis. The overall CR rate was significantly higher in the H arm than in the E arm (79.9% v 73.9%, P = .014). According to the intention-to-treat analysis, the 3-year OS was 69.2% (95% CI, 65.1 to 72.9) in the H arm and 62.8% (95% CI, 58.7 to 66.6) in the E arm (P = .025); the 3-year EFS was 61.1% (95% CI, 56.8 to 65.0) in the H arm and 53.4% (95% CI, 49.2 to 57.3) in the E arm (P = .022). Among the per-protocol population, who received maintenance therapy, the 3-year EFS did not differ significantly across the four arms (H + AT arm: 70.7%, 95% CI, 61.1 to 78.3; H + AC arm: 74.8%, 95% CI, 67.0 to 81.0, P = .933; E + AC arm: 72.9%, 95% CI, 65.1 to 79.2, P = .789; E + AT arm: 66.2%, 95% CI, 56.8 to 74.0, P = .336). CONCLUSION HHT is an alternative combination regimen for childhood AML. The effects of ATRA-based maintenance are comparable with those of cytarabine-based maintenance therapy.
Trudinger-Moser type inequality and existence of solution for perturbed non-local elliptic operators with exponential nonlinearity

In this paper we consider the following perturbed nonlocal problem with exponential nonlinearity 1 \begin{document}$\begin{cases}-\mathcal{L}_{K}u+ \left|u\right|^{p-2}u+h(u)= f \ \ \ \ \ \mbox{in} \ \ \Omega,\\u=0, \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \mbox{in}\ \ \mathbb{R}^{N}\setminus \Omega,\end{cases}$\end{document} where $s\in (0, 1)$, $N=ps$, $p\geq 2$ and $f\in L. {\infty}(\mathbb{R}^{N})$. First, we generalize a suitable Trudinger-Moser inequality to a fractional functional space. Then, using the Ekeland's variational principle, we prove the existence of a solution of problem (1).
How to Gamble if You Must. (Inequalities for Stochastic Processes) By Lester E. Dubins and Leonard J. Savage. Pp. xiv, 249. 102s. 1965. (McGraw-Hill Book Co.)

cu rve ; the re is also some extension of t he chap te rs on differential equat ions . The au tho r suggests t h a t t he addi t ions are so m a n y t h a t t he book can a lmost be regarded as a new one. Other readers m a y no t share th i s view, for a ve ry subs tan t ia l amoun t of the earlier t e x t is completely reproduced here, a n d in other places t he modifications are of t he slightest . This, however, is no t t o be regarded as a n adverse criticism. Mr. Pedoe ' s books h a v e been successful sellers, a n d clearly satisfy a par t icu lar m a r k e t . The s t ruc ture of na t iona l certificate courses is now changing; t h e number s a n d background of en t r an t s are somewhat unpredic table , a n d t h e future relat ionships of t he certificate t o membership of t he professional ins t i tu t ions a re doubtful . B u t the re will b e m a n y engineers requir ing ma thema t i c s books of this na tu r e . Colleges and teachers favouring the first edit ion will certainly cont inue t o favour the second also.
Lectures on K3 Surfaces

K3 surfaces are central objects in modern algebraic geometry. This book examines this important class of Calabi–Yau manifolds from various perspectives in eighteen self-contained chapters. It starts with the basics and guides the reader to recent breakthroughs, such as the proof of the Tate conjecture for K3 surfaces and structural results on Chow groups. Powerful general techniques are introduced to study the many facets of K3 surfaces, including arithmetic, homological, and differential geometric aspects. In this context, the book covers Hodge structures, moduli spaces, periods, derived categories, birational techniques, Chow rings, and deformation theory. Famous open conjectures, for example the conjectures of Calabi, Weil, and Artin–Tate, are discussed in general and for K3 surfaces in particular, and each chapter ends with questions and open problems. Based on lectures at the advanced graduate level, this book is suitable for courses and as a reference for researchers.
Discrimination between keratoconus, forme fruste keratoconus, and normal eyes using a novel OCT-based tomographer

Combining anterior and posterior curvature variables with pachymetric data obtained from a new SS-OCT (Anterion) allows automated detection of early keratoconus and keratoconus with very good accuracy. Purpose: To combine objective machine-derived corneal parameters obtained with new swept-source optical coherence tomography (SS-OCT) tomographer (Anterion) to differentiate between normal (N), keratoconus (KC) and forme fruste KC (FFKC). Setting: Laser Center, Hôpital Fondation Adolphe de Rothschild, Paris, France. Design: Retrospective study. Methods: 281 eyes of 281 patients were included and divided into 3 groups: N (n = 156), FFKC (n = 43), and KC (n = 82). Eyes were included in each group based on objective evaluation using Nidek Corneal Navigator, and subjective evaluation by authors. The SS-OCT system provided anterior and posterior corneal surface and pachymetry derived variables. The training set was composed of 143 eyes (95 N, 43 FFKC). Discriminant analysis was used to determine the group of an observation based on a set of variables. The obtained formula was tested in the validation set composed of 61 N and 82 KC. Results: Among curvature parameters, the FFKC had significantly higher irregularity index at 3 mm and 5 mm, higher inferior-superior index, higher SteepK-OppositeK index and inferiorly decentered posterior steepest keratometry. Among thickness parameters: central pachymetry, thinnest pachymetry, percentage of thickness increase from center to periphery, and inferior decentration of the thinnest point were statistically different between groups. Combination of multiple variables into a discriminant function (F1) included 5 parameters and reached an area under the receiver operating characteristic curve (AUROC) of 0.95 (sensitivity = 75%, specificity = 98.5%) for detection of FFKC. F1 differentiates N from KC with AUROC = 0.99 (sensitivity = 99%, specificity = 99%). Conclusions: Combining anterior and posterior curvatures variables along with pachymetric data obtained from SS-OCT allowed automated detection of early KC and KC with very good accuracy (87% and 99.5% respectively).
QTc prolongation in patients with schizophrenia taking antipsychotics: Prevalence and risk factors

Background: QTc prolongation is one of the possible complications in patients with schizophrenia taking antipsychotics, which leads to malignant cardiac arrhythmia. No meta-analysis has been reported assessing the prevalence and correlated risk factors for QTc prolongation. Methods: This meta-analysis aimed to assess the evidence for the prevalence of QTc prolongation and correlated risk factors in patients with schizophrenia taking antipsychotics. Web of Science and PubMed were searched according to preset strategy. The quality of research was assessed by the Newcastle–Ottawa Scale (NOS). Results: In all, 15 studies covering 15,540 patients with schizophrenia taking antipsychotics were included. Meta-analysis showed that the prevalence of QTc prolongation in patients with schizophrenia taking antipsychotics was about 4.0% (95% confidence interval (CI): 3.0%–5.0%, p < 0.001). The prevalence was about 4.0% in Asia (95%CI: 3.0%–6.0%, p < 0.001), about 5.0% in Europe (95%CI: 2.0%–7.0%, p < 0.001), and about 2.0% in America (95%CI: 1.0%–3.0%, p < 0.001). Sensitivity analyses indicated the robustness of the result. Publication bias analysis reported a certain publication bias (t = 3.37, p = 0.012). Meta-regression suggested that female and elderly patients were clinically associated with a higher prevalence of QTc prolongation. According to included studies, smoking, comorbidity of cardiovascular disease, and abnormal levels of high-density lipoprotein/low-density lipoprotein might be related to QTc prolongation in patients with schizophrenia taking antipsychotics. Conclusions: The prevalence of QTc prolongation in patients with schizophrenia taking antipsychotics was about 4.0%. Female and elderly patients were more likely to experience QTc prolongation. Close electrocardiogram monitoring was suggested in these at-risk populations.
Krylov Integration Factor Method for High Spatial Dimension Convection-Diffusion Problems on Sparse Grids

by Dong Lu Integration factor (IF) methods are a class of efficient time discretization methods for solving stiff problems via evaluation of an exponential function of the corresponding matrix for the stiff operator. The computational challenge in applying the methods for partial differential equations (PDEs) on high spatial dimensions (multidimensional PDEs) is how to deal with the matrix exponential for very large matrices. Compact integration factor methods developed in [Nie et al., Journal of Computational Physics, 227 (2008) 5238-5255] provide an approach to reduce the cost prohibitive large matrix exponentials for linear diffusion operators with constant diffusion coefficients in high spatial dimensions to a series of much smaller one dimensional computations. This approach is further developed in [Wang et al., Journal of Computational Physics, 258 (2014) 585-600] to deal with more complicated high dimensional reaction-diffusion equations with cross-derivatives in diffusion operators. Another approach is to use Krylov subspace approximations to efficiently calculate large matrix exponentials. In [Chen and Zhang, Journal of Computational Physics, 230 (2011) 4336-4352], Krylov subspace approximation is directly applied to the implicit integration factor (IIF) methods for solving high dimensional reaction-diffusion problems. Recently the method is combined with weighted essentially non-oscillatory (WENO) schemes in [Jiang and Zhang, Journal of Computational Physics, 253 (2013) 368-
Lawin Transformer: Improving New-Era Vision Backbones with Multi-Scale Representations for Semantic Segmentation

The multi-level aggregation (MLA) module has emerged as a critical component for advancing new-era vision back-bones in semantic segmentation. In this paper, we pro-pose Lawin ( la rge win dow) Transformer, a novel MLA architecture that creatively utilizes multi-scale feature maps from the vision backbone. At the core of Lawin Trans-former is the Lawin attention, a newly designed window attention mechanism capable of querying much larger context windows than local windows. We focus on studying the efficient and simplistic application of the large-window paradigm, allowing for flexible regulation of the ratio of large context to query and capturing multi-scale representations. We validate the effectiveness of Lawin Transformer on Cityscapes and ADE20K, consistently demonstrating great superiority to widely-used MLA modules when combined with new-era vision backbones. The code is available at https://github.com/yan-hao-tian/lawin.
A large deformation model for quasi-static to high strain rate response of rate-stiﬀening soft polymers

Soft polymers and polymer gels that contain dynamic, reversible crosslinks are rate-dependent materials used in applications ranging from biomedical to structural protection. Their highly rate-dependent response, especially for impact-mitigating structures, is important. Currently, there are no physics-motivated constitutive models that can predict the large-deformation elastic-viscoplastic response of these polymers at high loading rates (strain rates ∼ 10 3 s − 1 ). To address this gap, we have developed a constitutive model for rate-stiﬀening soft polymers with dynamic crosslinks to predict their large strain, non-linear, loading-unloading, and substantial rate-dependent response. We have conducted compression experiments on polyborosiloxane (PBS), an important rate-stiﬀening soft polymer with dynamic crosslinks, up to true strains of ∼ 125%, over a wide strain rate range of 10 − 3 s − 1 to 10 3 s − 1 . The model reasonably accurately captures the response of PBS over six decades of strain rates. We propose boron-oxygen coordinate-bond dynamic crosslinks with relaxation time constant τ ≈ 3 s and entanglements acting as dynamic crosslinks with τ ≈ 0 . 001 s as the two main types of crosslink mechanisms in PBS. We have outlined a numerical update procedure to evaluate the convolution-like time integrals arising from dynamic crosslink kinetics. The predictive capabilities of our model and its ﬁnite element implementation are validated using experiments involving three-dimensional inhomogeneous deformations.
Synthesis of Point Planar Elastic Behaviors Using Three-Joint Serial Mechanisms of Specified Construction

This paper presents methods for the realization of 2 2 translational compliance matrices using serial mechanisms having three joints, each either revolute or prismatic and each with selectable compliance. The geometry of the mechanism and the location of the compliance frame relative to the mechanism base are each arbitrary but specified. Necessary and sufficient conditions for the realization of a given compliance with a given mechanism are obtained. We show that, for an appropriately constructed serial mechanism having at least one revolute joint, any single 2 2 compliance matrix can be realized by properly choosing the joint compliances and the mechanism configuration. For each type of three-joint combination, requirements on the redundant mechanism geometry are identified for the realization of every point planar elastic behavior at a given location, just by changing the mechanism configuration and the joint compliances. [DOI: 10.1115/1.4035189]
Joint Viewpoint and Keypoint Estimation with Real and Synthetic Data (Supplemental Material)

For the sake of completeness, we also evaluate our method on the popular Pascal3D+ dataset [4], which also contains the same 12 classes evaluated on the ObjectNet3D dataset [5]. Compared to ObjectNet3D, this dataset provides object instances that are not centred in the middle of the image and can thus be found in any image location with different resolutions, producing more challenging scenarios. We follow the standard protocol when the keypoint and viewpoint accuracies are jointly evaluated. That is, for training our network we make use of all 5790 samples included in the training subset together with 28769 additional samples from the ImageNet dataset [2]. We only report our results on the fully visible objects of the test dataset, for a total of 2136 samples, with roughly 200-300 samples per class. We report our trained network JVK with only real images (Re) and with real images together with the synthetic examples from the ShapeNet dataset [1] (Re-Sh). For both keypoint and viewpoint estimation results, we compare our method with the popular work by Tulsiani et al. (VpKp) and the State-of-theArt method by Zhou et al. [6] (StarMap).
Assessing the Resolution Adaptability of the Zhang‐McFarlane Cumulus Parameterization With Spatial and Temporal Averaging

With increasing computational capabilities, cumulus parameterizations that are adaptable to the smaller grid spacing and temporal interval for high‐resolution climate model simulations are needed. In this study, we propose a method to improve the resolution adaptability of the Zhang‐McFarlane (ZM) scheme, by implementing spatial and temporal averaging to the CAPE tendency. This method allows for a more consistent application of the quasi‐equilibrium (QE) hypothesis at high spatial and temporal resolutions. The resolution adaptability of the original ZM scheme, the scheme with spatial averaging, and the scheme with spatiotemporal averaging at 4–32 km grid spacings are assessed using the Weather Research and Forecasting (WRF) model by comparing to cloud resolving model (CRM) simulation results coarse‐grained to these same grid spacings. We show the original ZM scheme has poor resolution adaptability, with spatiotemporally averaged subgrid convective transport and convective precipitation increasing significantly as the resolution increases. The spatial averaging method improves the resolution adaptability of the ZM scheme and better conserves total transport and total precipitation. Temporal averaging further improves the resolution adaptability of the scheme. With better constrained (although smoothed) convective transport and precipitation, both the spatial distribution and time series of total precipitation at 4 and 8 km grid spacings are improved with the averaging methods. The results could help develop resolution adaptability for other cumulus parameterizations that are based on the QE assumption.
Les $1$-graphes finis et leurs morphismes

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Modular robots

Modular reconfigurable robots-experimental systems made by interconnecting multiple, simple, similar units-can perform shape shifting. A robot made up of a chain of simple hinge joints could shape itself into a loop and move by rolling like a self-propelled tank tread; then break open the loop to form a serpentine configuration and slither under or over obstacles; and then rearrange its modules to "morph" into a multilegged spider, able to stride over rocks and bumpy terrain. This robot, dubbed PolyBot, is being built and experimented with at Xerox Palo Alto Research Center (PARC), in California. This paper describes the main features of PolyBot and how it works. Programming of PolyBot is also discussed.
VLBI Observations of Southern Gamma-Ray Sources. III

Abstract We report the results of Long Baseline Array observations made in 2001 of ten southern sources proposed by Mattox et al. as counterparts to EGRET >100 MeV gamma-ray sources. Source structures are compared with published data where available and possible superluminal motions identified in several cases. The associations are examined in the light of Fermi observations, indicating that the confirmed counterparts tend to have radio properties consistent with other identifications, including flat radio spectral index, high brightness temperature, greater radio variability, and higher core dominance.
Learning Adversarial MDPs with Bandit Feedback and Unknown Transition

We consider the problem of learning in episodic finite-horizon Markov decision processes with an unknown transition function, bandit feedback, and adversarial losses. We propose an efficient algorithm that achieves $\mathcal{\tilde{O}}(L|X|\sqrt{|A|T})$ regret with high probability, where $L$ is the horizon, $|X|$ is the number of states, $|A|$ is the number of actions, and $T$ is the number of episodes. To the best of our knowledge, our algorithm is the first to ensure $\mathcal{\tilde{O}}(\sqrt{T})$ regret in this challenging setting; in fact it achieves the same regret bound as (Rosenberg & Mansour, 2019a) that considers an easier setting with full-information feedback. Our key technical contributions are two-fold: a tighter confidence set for the transition function, and an optimistic loss estimator that is inversely weighted by an $\textit{upper occupancy bound}$.
Canavan Disease: First Normocephalic Case from North Cyprus

Canavan disease is an autosomal recessively inherited leukodystrophy characterized by white matter degeneration. The defective gene is the aspartoacylase gene that encodes the enzyme aspartoacylase. Head lag, macrocephaly, and hypotonia are the primary characteristic physical examination findings. A 6 month-old patient presented with developmental delay and normocephaly. Brain magnetic resonance imaging showed delayed myelinization at the corpus callosum, genu of the internal capsule, and posterior limb and hyperintensity of the globus pallidus, thalamus, dorsal aspect of the brain stem, corticospinal tract, and cerebellum. Magnetic resonance spectroscopy demonstrated a prominent N-acetyl aspartate peak, which is a typical pathological finding. Genetic testing revealed the presence of a homozygous c.79, G>A (p.G27R) mutation, which confirmed the diagnosis of Canavan disease. During follow-ups, the child was normocephalic, even at the 1 year visit.
Unique Ergodicity in the Interconnections of Ensembles with Applications to Two-Sided Markets

There has been much recent interest in two-sided markets and dynamics thereof. In a rather a general discretetime feedback model, we show conditions that ensure that for each agent, there exists the limit of a long-run average allocation of a resource to the agent, which is independent of any initial conditions. We call this property unique ergodicity. Our model encompasses two-sided markets and more complicated interconnections of workers and customers, such as in a supply chain. It allows for non-linearity of the response functions of market participants. It allows for uncertainty in the response of market participants by considering a set of the possible responses to either price or other signals and a measure to sample from these. Finally, it allows for an arbitrary delay between the arrival of incoming data and the clearing of a market.
Study of correlation between hand circumference and maximum grip strength (MGS)

Background: Normal hand grip strength is positively related to normal bone mineral density in postmenopausal women and increased mortality from cardiovascular disease and from cancer in men. Aims & Objective: The objective of this study was to establish the correlations between anthropometric data and Body Mass Index (BMI) with maximal grip strength (MGS). Materials and Methods: 40 males and 40 females in the age group 17-19 years were recruited for the study. MGS was measured with a computerized Hand Dynamometer (AD Instrument, Australia). BMI, forearm circumference and hand circumference were measured. Results: There was a positive correlation between all anthropometric data and MGS in both males and females. The hand circumference had the strongest correlation with MGS in both males and females for right hand. However, the correlation was observed only in females for the left hand. Conclusion: Hand circumference is a good indicator to predict normal MGS than BMI and forearm circumference.