Miracle-dz/UniFAR-FTUs huggingface dataset:
mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4+ T Cell Apoptosis Mediated by ROS in Septic Immunosuppression

Introduction When sepsis attacks the body, the excessive reactive oxygen species (ROS) production can result to endoplasmic reticulum stress (ERS) and eventually cause lymphocyte apoptosis. The mammalian target of rapamycin (mTOR) is essential for regulating lymphocyte apoptosis; we hypothesized that it mediates CD4+ T cell apoptosis during ROS-related ERS. Method We, respectively, used ROS and ERS blockers to intervene septic mice and then detected ERS protein expression levels to verify the relationship between them. Additionally, we constructed T cell-specific mTOR and TSC1 gene knockout mice to determine the role of mTOR in ROS-mediated, ERS-induced CD4+ T cell apoptosis. Results Blocking ROS significantly suppressed the CD4+ T cell apoptosis associated with the reduction in ERS, as revealed by lower levels of GRP78 and CHOP. ERS rapidly induced mTOR activation, leading to the induction of CD4+ T cell apoptosis. However, mTOR knockout mice displayed reduced expression of apoptotic proteins and less ER vesiculation and expansion than what was observed in the wild-type sepsis controls. Conclusion By working to alleviate ROS-mediated, ERS-induced CD4+ T cell apoptosis, the mTOR pathway is vital for CD4+ T cell survival in sepsis mouse model.
Phonological Development Profile in Typically Developing Hindi Speaking Children

The present cross sectional study aimed to delineate the phonological development across 2 ½ to 6 ½ years of typically developing Hindi speaking children. A total of 80 children from Mumbai who were further sub divided into 4 groups i.e. 2 ½ - 3 ½ years, 3 ½ -4 ½ years, 4 ½ -5 ½ years and 5 ½ - 6 ½ years with each group constituting 10 females and 10 males participated in the study. The inclusion criteria for the children was native Hindi speaking with normal oral peripheral mechanism, attending Hindi medium school and with no associated problems. The Photo articulation test in Hindi was administered on all the children. A total of 16 vowels, 30 consonants and 11 blends were assessed. The children responses were recorded using Sony digital audio recorder and further transcribed in broad IPA by the researcher. A phoneme acquisition criterion of 80% and above was selected for all the phonemes to be considered as acquired. The data was subjected to descriptive statistical analysis to identify mean and standard deviation values and further the mean scores were converted into percentages. The results indicated a clear correlation between the features of the phonemes and their age of acquisition. This age wise wide range of data will add to the present normative information in Hindi speaking population and can be used to differentiate between phonological disorders and normal acquisition.
Bandwidth constraint optimization for speckle-suppressed computational holographic projection

Bandwidth constraint optimization method is proposed to design phase-only holograms for speckle-suppressed and ringing artifacts-free computational holographic projection. The bandwidth properties of the reconstructed wave field are analyzed, which helps to effectively sample and describe the reconstructed intensity distribution based on the sampling theorem. Iterative calculation with bandwidth constraint strategy and quadratic initial phase can optimize phase-only holograms without vortex-stagnation problem. The proposed method can effectively suppress the speckle noise as well as the ringing artifacts. Numerical and optical experiments have been performed to validate the feasibility of the proposed method for achieving high-quality holographic projection.
Evaluation of Prescription Pattern and Medication Adherence in Patients with Alcoholic Liver Disease

Background: ALD is the most common cause of morbidity and mortality among patients. A patient’s Medication Non-Adherence may also interfere with the progression of Disease. Analysis of Prescription pattern in ALD helps to ensure the safety of the Patient by assessing the signs and symptoms of disease and its appropriate therapy. Thus, educating the patients regarding their clinical condition will have a significant role in reducing the severity of the disease. Aim: To assess the Prescription pattern, Medication Adherence and to identify the correlation between the medication adherence and the educational status in ALD patients. Materials and Methods: The Study was a Prospective Observational study carried out for a duration of Six months. Morisky Green Levine scale was the tool used to assess the medication adherence. Data was collected using a self-designed data collection form. Results: A Total of 160 Alcoholic subjects were assessed during the study period among which 65.62% of them were illiterate. Out of total cases 76.87 % of hepatoprotective drugs, 50.62% antiemetics, 38% vitamins and 11% of anti-ulcer drugs were prescribed among patients. It was found that there exist a relationship between educational status and medication adherence (P-value: 0.0021). Conclusion: The study helped to assess the different class of drugs, drugs used in different comorbid conditions and also to evaluate, identify and solve the problems associated with the Medication Non-Adherence of the patients. Keywords: Medication Adherence, Alcoholic Liver Disease, Rational Drug Therapy.
Automatic Collision Avoidance for Teleoperated Underactuated Aerial Vehicles using Telemetric Measurements

The paper deals with the obstacle avoidance problem for unmanned aerial vehicles (UAVs) operating in teleoperated mode. First, a feedback controller that we proposed recently for the stabilization of the UAV's linear velocity is recalled. Then, based on sensory measurements, a control strategy is proposed in order to modify the reference velocity on-line in the neighborhood of obstacles so as to avoid collisions. Both cases of telemetry and optical flow sensors are addressed. Stability properties of the proposed feedback controller are established based on a Lyapunov analysis. Simulations results are reported to illustrate the approach.
A Theoretical Proposal for an Ultrabroadband Metamaterial Absorber for the Circular Polarization Waves Based on Anapole Mode in the Near‐Infrared Region

The absorber excited by anapole response is in the spotlight owing to its non‐radiating merits, whereas the existing designs suffer from poor bandwidth and absorption. Furthermore, the circular polarization (CP) wave promises numerous application scenarios; thus, the absorbers aimed at it are sorely called for. An ultrabroadband metamaterial absorber (MMA) for the CP waves based on anapole mode is proposed in this paper. In this structure, the symmetrical split‐ring resonators (SRRs) are acted as the resonant unit to excite the toroidal dipole (TP) and electric dipole (EP) moments in the near‐infrared region. By applying the perfect electric conductor mirror effect, the enhanced field energy results in the absorption peak in the given band. Aimed at optimizing the absorption performance of the designed MMA, the SRRs are rotated, introduce the cavity resonance, and add the nickel patch to excite more electromagnetic resonance. The final optimized MMA can achieve an absorption exceeding 90% in an ultrabroadband of 1228–2156.7 nm, whose relative absorption bandwidth is 54.9%. Meanwhile, on account of its highly symmetrical structure, the MMA is insensitive to the polarization state of the CP waves. These splendid properties make the MMA a good candidate for potential applications.
The Relationship Between Leadership Style and Work Motivation with Burnout Syndrome in Nurses during the Covid 19 Pandemic

The high number of patients, inadequate hospital facilities, and the high risk of exposure to diseases during the covid 19 pandemic make nurses experience Burnout syndrome. This research is a correlational analysis with a cross sectional approach. A population of 60 respondents with simple random sampling techniques. Independent variables are leadership styles and work motivation, while variable dependencies are burnout syndrome in nurses. Instrument research using the Maslach Burnout Syndrome Inventory (MBI) questionnaire. Analysts test used Kendall's tau_b and Spearman Rank test with @=0.05. The results showed that 55% of respondents aged 31-40 years, 90% of marital status, 55% of female sex, 53,3% of Ners education level and 56.6% length of work more than 10 years. Statistics test showed there was a relationship between leadership style and burnout syndrome in nurses with test results (p=0.047 < @=0.05).
Investigation of Morphological, Optical, and Dielectric Properties of RF Sputtered WOx Thin Films for Optoelectronic Applications

Tungsten oxide (WOx) thin films were synthesized through the RF magnetron sputtering method by varying the sputtering power from 30 W to 80 W. Different investigations have been conducted to evaluate the variation in different morphological, optical, and dielectric properties with the sputtering power and prove the possibility of using WOx in optoelectronic applications. An Energy Dispersive X-ray (EDX), stylus profilometer, and atomic force microscope (AFM) have been used to investigate the dependency of morphological properties on sputtering power. Transmittance, absorbance, and reflectance of the films, investigated by Ultraviolet-Visible (UV-Vis) spectroscopy, have allowed for further determination of some necessary parameters, such as absorption coefficient, penetration depth, optical band energy gap, refractive index, extinction coefficient, dielectric parameters, a few types of loss parameters, etc. Variations in these parameters with the incident light spectrum have been closely analyzed. Some important parameters such as transmittance (above 80%), optical band energy gap (~3.7 eV), and refractive index (~2) ensure that as-grown WOx films can be used in some optoelectronic applications, mainly in photovoltaic research. Furthermore, strong dependencies of all evaluated parameters on the sputtering power were found, which are to be of great use for developing the films with the required properties.
Effect of zinc deficiency on hair loss in pregnant women

Zinc and iron, for example, are crucial trace elements for pregnant women's health. This study has been conducted for the evaluation of zinc and ferritin status of pregnant women since these elements have significant effects on health of the pregnant women as well as the growing embryo in Al Muthanna Province/ Iraq. Seventy five samples of this study were gathered from the three studied groups (Control, pregnant women with Hair Losing and non-pregnant women with Hair Losing) in the Central Health Laboratory of Al Muthanna Province through the period from November 2020 to May 2021, blood samples were collected for further analysis Conclusions : According to the findings of this study, serum zinc and ferritin levels are frequently low in pregnant women who complain of hair loss. Overall, zinc and ferritin insufficiency in Iraq is a major public health concern. Improving nutritional diversity aids in solving the risk among the study participants.
Mathematical Modeling Analysis of Data Attribute Encryption for Robot

Encrypting data based on the data attributes of robots is one of the effective methods to control access users in the data outsourcing environment. Therefore, a mathematical modeling method of robot data attribute encryption based on data redundancy elimination technology is proposed. The encryption algorithm structure is analyzed based on the Bloom filter. The Hamming distance is used to calculate the similarity of big data by the Bloom filter. Finally, a big data ellipse encryption algorithm is designed according to the calculation results. The results show that during the whole experiment, the approximate fluctuation range is 0.08%~0.14%, which is not only high but also has a large fluctuation range. In contrast, the probability of occurrence of redundant data is less than 0.05% under different byte rates of redundant data, which is far lower than the two traditional methods, indicating that the application performance of the proposed method is good.
A PHASE DIVERSITY PRINTED-DIPOLE ANTENNA ELEMENT FOR PATTERNS SELECTIVITY ARRAY APPLICATION

A phase diversity printed-dipole antenna element for patterns selectivity array application is designed in this paper. The antenna element consists of a printed dipole structure and two varactors. By changing the control voltage of each element, various radiation phases in the far field of each element is realized, that is, the peak gain direction of the array is changed. With this method, the structure designed is simple, and only two varactors are loaded. To verify the feasibility, an antenna prototype is experimentally characterized, which validates the proposed concept. The impedance bandwidth of array is 22.2% (3.2 ∼ 4.0GHz), in which the peak gain direction can be scanned during angles from −θ to +θ across broadside (θ = 13◦ ∼ 18◦ at different frequencies). It can be applied to phased antenna system.
A tool for reflection—on participant diversity and changeability over time in participatory design

Abstract The expansion of participatory design, from a Scandinavian workplace context, to also include the public sphere, communities and developing countries, has led to a high diversification of participants. However, these new types of participant groups are often addressed in a simplistic manner, viewed as homogenous entities, without consideration being given to the fact that they may consist of subgroups and individuals, all with different needs and preconditions to participate. Further, there seems to be little understanding of the fact that people’s situations are not static, but changes over time as a project unfolds. In this article, it is argued that focus needs to be put on reflection of participant diversity and changeability over time. An example is given of how a tool for reflection can facilitate this, give visual form to complex situations, highlight differences between groups and indicate how participants’ positions alter over time. It is proposed that the tool can enable design researchers to reflect collectively about how different groups should be involved, as well as on the effect that project actions and decisions can have on participants.
Application of Multi-Objective Artificial Bee Colony Optimization for CBIR System

Multi-objective optimization has been a challenging area and focus for research. This paper presents an optimization algorithm based on artificial bee colony (ABC) to deal with multi-objective optimization problems in CBIR. We have introduced a multi-object ABC algorithm which is based on the intelligent scavenging behaviour for content base images. It uses less control parameters, and it can be efficiently used for solving for multi object optimization problems. In the current work, MOABC for discrete variables has been developed and implemented successfully for the multi-objective design optimization of composites. The performance is estimated in comparison with other nature-inspired techniques, which includes Multi-objective Particle Swarm Optimization (MOPSO) and Multi-objective Genetic Algorithm (MOGA). The performance of MOABC is better as par with that of MOPSO, MOGA and ABC for all the loading configurations.
Analysis of defocus invariance of typical wavefront coding phase mask under temperature gradient environment

The wavefront coding technology can improve the depth of focus of traditional optical systems. Thus, the influence of thermal defocus on the imaging quality of the infrared system canbe effectively reduced when applied the wavefront coding technology to the athermalization design process. Till now, the analysis of the athermalization wavefront coding system is all under the uniform temperature distribution condition. Aiming at the environment with uneven temperature and gradient distribution, this paper used the temperature gradient polynomial to simulate the temperature distribution model, and calculated the phase function of the typical phase mask. Modulation transfer function (MTF) and point spread function (PSF) are calculated by simulation methods. And analyzing the effects of different temperature gradient values and different temperature gradient orders by Hilbert angle, MTF area and Fisher information. The simulation results show that, the typical wavefront coding phase mask can work normal under a certain range of temperature gradient. When the simulation had been done at the thickness of the phase mask is 4mm and radius is 6mm, the cubic phase mask can still work properly in the gradient range [−10oC/mm, 10oC/mm . And the larger gradient order, the the greater the influence on the imaging of wavefront coding system.
HsfA1a confers pollen thermotolerance through upregulating antioxidant capacity, protein repair, and degradation in Solanum lycopersicum L.

Abstract The heat shock transcription factors (Hsfs) play critical roles in plant responses to abiotic stresses. However, the mechanism of Hsfs in the regulation of pollen thermotolerance and their specific biological functions and signaling remain unclear. Herein, we demonstrate that HsfA1a played a key role in tomato pollen thermotolerance. Pollen thermotolerance was reduced in hsfA1a mutants but was increased by hsfA1a overexpression, based on pollen viability and germination. Analyzing the whole transcriptome by RNA-seq data, we found that HsfA1a mainly regulated the genes involved in oxidative stress protection, protein homeostasis regulation and protein modification, as well as the response to biological stress in anthers under heat stress. The accumulation of reactive oxygen species in anthers was enhanced in hsfA1a mutants but decreased in HsfA1a-overexpressing lines. Furthermore, HsfA1a bound to the promoter region of genes involved in redox regulation (Cu/Zn-SOD, GST8, and MDAR1), protein repair (HSP17.6A, HSP70-2, HSP90-2, and HSP101) and degradation (UBP5, UBP18, RPN10a, and ATG10) and regulated the expression of these genes in tomato anthers under heat stress. Our findings suggest that HsfA1a maintains pollen thermotolerance and cellular homeostasis by enhancing antioxidant capacity and protein repair and degradation, ultimately improving pollen viability and fertility.
The Global Distributive Impact of the US Inflation Shock

We study the global distributive consequences of the “Great Reflation. ” The conven-tional wisdom holds that the increases in interest rates resulting from high inflation in the United States will have a negative impact on the rest of the world (and developing countries in particular) due to the reversal of capital flows and higher financing costs. We show that the standard view fails to take into account an important countervailing force: the effect of higher US inflation on the changing real value of nominal US dollar assets and liabilities across countries. Decades of low inflation led to widespread use of dollar-denominated financial instruments with fixed interest rates and long maturities. Unanticipated inflation in the US diminishes the real value of dollar-denominated sovereign debt, both in the US and abroad. For sovereigns other than the US, the gains are equivalent to a debt relief of about $100 billion. On the other hand, the US government gains nearly $2 trillion on its debt and cash liabilities, of which fully one-quarter (over $500 billion) is paid by non-residents.
Collapse of a self-similar cylindrical scalar field with non-minimal coupling

We investigate self-similar scalar field solutions to the Einstein equations in whole cylinder symmetry. Imposing self-similarity on the spacetime gives rise to a set of single variable functions describing the metric. Furthermore, it is shown that the scalar field is dependent on a single unknown function of the same variable and that the scalar field potential has exponential form. The Einstein equations then take the form of a set of ODEs. Self-similarity also gives rise to a singularity at the scaling origin. We discuss the number of degrees of freedom at an arbitrary point and prove existence and uniqueness of a 2-parameter family of solutions with a regular axis. We discuss the evolution of these solutions away from the axis toward the past null cone of the singularity, determining the maximal interval of existence in each case.
Effects of Cervical Spine Exercise Protocol on Neck Pain, Pericervical Muscle Endurance, and Range of Motion in Medical Students: A Prospective Study

Introduction Neck pain is a common and debilitating ailment that places a significant burden on the healthcare system. No practical protocols have been published utilizing a portable, commercially available, and affordable device that significantly reduces acute and chronic neck pain. Methods Forty-six young adults with or without mild-to-moderate neck pain completed a six-week neck stretching and strengthening protocol with a portable cervical stretching and strengthening device. The primary outcome was changes to pericervical muscle endurance. Secondary outcomes were changes to cervical range of motion (ROM), neck length, circumference, and subjective pain, flexibility, and strength. Measurements were obtained on study days 0, 21, and 42. Results A significant increase in pericervical muscle endurance was demonstrated across all planes of cervical motion, ranging from 84% to 105%. Cervical ROM improved across all planes of motion but was only significant in right-side bending (5.3°), left rotation (6.2°), and right rotation (7.8°). Subjective pain evaluated via the Numeric Rating Scale (NRS) saw statistically significant improvement as well (1.33 to 0.51). Subjective assessment of participant cervical pain, strength, and flexibility improved 61.3%, 95.7%, and 97.8%, respectively. Conclusions A six-week pericervical muscle stretching and strengthening program increased pericervical endurance and ROM in young adults. Decreased cervical pain was seen using the NRS and modified pain scale across most participants.
A Very Uncommon Case of Myxedema Coma: Rediscovery of an Old Presentation

Myxedema coma is an extreme manifestation of hypothyroidism. It is characterized by altered mental status and hypothermia. The most common precipitants of myxedema coma include discontinuation of thyroid supplements and infections. Therefore, the mainstay of treatment is IV glucocorticoids and IV levothyroxine. We describe a case of an 81-year-old woman with myxedema coma who developed acute cardiopulmonary failure with associated pericardial and pleural effusions, which are rare manifestations of myxedema coma.
Anemia and Heart Failure: A Narrative Review

Anemia in heart failure patients is a relatively common finding and has been linked with an increased risk of hospital admissions, morbidities, and significant mortality making its correction a significant factor in improving the quality of life and clinical outcomes in those suffering from it. This review article has discussed the multifactorial pathophysiology, including iron deficiency, longstanding inflammation, abnormal levels of human erythropoietin (Epo), and the abnormal activation of the renin-angiotensin-aldosterone system (RAAS) being the most significant. The diagnostic guidelines as well as research-based management modalities specifically with iron supplements and erythropoietin stimulating agents have also been discussed, although research done in this area has been limited and shown conflicting results.