Miracle-dz/UniFAR-FTUs huggingface dataset:
Detection of Genes in Arabidopsis thaliana L. Responding to DNA Damage from Radiation and Other Stressors in Spaceflight

Ionizing radiation present in extraterrestrial environment is an important factor that affects plants grown in spaceflight. Pearson correlation-based gene regulatory network inferencing from transcriptional responses of the plant Arabidopsis thaliana L. grown in real and simulated spaceflight conditions acquired by GeneLab, followed by topological and spectral analysis of the networks is performed. Gene regulatory subnetworks are extracted for DNA damage response processes. Analysis of radiation-induced ATR/ATM protein–protein interactions in Arabidopsis reveals interaction profile similarities under low radiation doses suggesting novel mechanisms of DNA damage response involving non-radiation-induced genes regulating other stress responses in spaceflight. The Jaccard similarity index shows that the genes AT2G31320, AT4G21070, AT2G46610, and AT3G27060 perform similar functions under low doses of radiation. The incremental association Markov blanket method reveals non-radiation-induced genes linking DNA damage response to root growth and plant development. Eighteen radiation-induced genes and sixteen non-radiation-induced gene players have been identified from the ATR/ATM protein interaction complexes involved in heat, salt, water, osmotic stress responses, and plant organogenesis. Network analysis and logistic regression ranking detected AT3G27060, AT1G07500, AT5G66140, and AT3G21280 as key gene players involved in DNA repair processes. High atomic weight, high energy, and gamma photon radiation result in higher intensity of DNA damage response in the plant resulting in elevated values for several network measures such as spectral gap and girth. Nineteen flavonoid and carotenoid pigment activations involved in pigment biosynthesis processes are identified in low radiation dose total light spaceflight environment but are not found to have significant regulations under very high radiation dose environment.
Feasibility of Preoperative Video Head Impulse Test to Predict the Nerve of Origin in Patients with Vestibular Schwannomas

Vestibular schwannoma (VS) originates from Schwann cells in the superior or inferior vestibular nerve. Identifying the precise origin will help in determining the optimal surgical approach. We retrospectively analyzed the preoperative vestibular function test according to VS origin to determine whether the test is a valuable indicator of tumor origin. Forty-seven patients with VS (male:female = 18:29, mean age: 54.06 ± 13.50 years) underwent the cochleovestibular function test (pure-tone audiometry, caloric test, video head impulse test (vHIT), cervical and ocular vestibular-evoked myogenic potential, and posturography). All patients then underwent surgical removal of VS, and the schwannoma origin was confirmed. The tumor originated from the superior vestibular nerve (SVN group) in 21 patients, the inferior vestibular nerve (IVN group) in 26 patients, and an undetermined site in eight patients. The only value that differed significantly among the groups was the gain of the vestibular-ocular reflex (VOR) in the ipsilesional posterior canal (iPC) during the vHIT. Our results indicate that VOR gain in the iPC may be used to predict the nerve origin in patients with VS. Other cochleovestibular function tests have limited value to discriminate nerve origins, especially in cases of medium to large VS.
Forecast of Outpatient Visits to a Tertiary Eyecare Network in India Using the EyeSmart Electronic Medical Record System

India is home to 1.3 billion people. The geography and the magnitude of the population present unique challenges in the delivery of healthcare services. The implementation of electronic health records and tools for conducting predictive modeling enables opportunities to explore time series data like patient inflow to the hospital. This study aims to analyze expected outpatient visits to the tertiary eyecare network in India using datasets from a domestically developed electronic medical record system (eyeSmart™) implemented across a large multitier ophthalmology network in India. Demographic information of 3,384,157 patient visits was obtained from eyeSmart EMR from August 2010 to December 2017 across the L.V. Prasad Eye Institute network. Age, gender, date of visit and time status of the patients were selected for analysis. The datapoints for each parameter from the patient visits were modeled using the seasonal autoregressive integrated moving average (SARIMA) modeling. SARIMA (0,0,1)(0,1,7)7 provided the best fit for predicting total outpatient visits. This study describes the prediction method of forecasting outpatient visits to a large eyecare network in India. The results of our model hold the potential to be used to support the decisions of resource planning in the delivery of eyecare services to patients.
The Concept of Folic Acid in Health and Disease

Folates have a pterine core structure and high metabolic activity due to their ability to accept electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential one-carbon pathways donating methyl-groups to choline phospholipids, creatine, epinephrine, DNA. Compounds similar to folates are ubiquitous and have been found in different animals, plants, and microorganisms. Folates enter the body from the diet and are also synthesized by intestinal bacteria with consequent adsorption from the colon. Three types of folate and antifolate cellular transporters have been found, differing in tissue localization, substrate affinity, type of transferring, and optimal pH for function. Laboratory criteria of folate deficiency are accepted by WHO. Severe folate deficiencies, manifesting in early life, are seen in hereditary folate malabsorption and cerebral folate deficiency. Acquired folate deficiency is quite common and is associated with poor diet and malabsorption, alcohol consumption, obesity, and kidney failure. Given the observational data that folates have a protective effect against neural tube defects, ischemic events, and cancer, food folic acid fortification was introduced in many countries. However, high physiological folate concentrations and folate overload may increase the risk of impaired brain development in embryogenesis and possess a growth advantage for precancerous altered cells.
Effectiveness of Acceptance and Commitment Therapy in Central Pain Sensitization Syndromes: A Systematic Review

Objectives: Acceptance and commitment therapy (ACT) is considered by the American Psychological Association as an evidence-based treatment for a variety of disorders, including chronic pain. The main objective of the present systematic review was to determine the effectiveness of ACT in patients with central pain sensitization syndromes (CPSS). Methods: This systematic review was conducted according to the guidelines of the Cochrane Collaboration and PRISMA statements. The protocol was registered in advance in the Prospective Register of Systematic Reviews (PROSPERO) international database. The selected articles were evaluated using the Cochrane risk of bias (ROB) assessment tool. The PubMed, Scopus, and Web of Science databases were searched. Results: The literature search identified 21 studies (including investigations of fibromyalgia syndrome, irritable bowel syndrome, and migraine) eligible for the systematic review. There were no studies regarding the effectiveness of ACT for chronic tension-type headache (CTTH), interstitial cystitis (IC), or temporomandibular disorder (TMD). The evaluation of ROB showed that 12 of the selected studies were of low quality, 5 were of moderate quality, and 4 were high quality. ACT reduces some clinical symptoms, such as anxiety, depression, and pain. This positive effect of ACT might be mediated by pain acceptance, psychological flexibility, optimism, self-efficacy, or adherence to values. ACT showed better results in comparison to non-intervention (e.g., “waiting list”) conditions, as well as pharmacological and psychoeducational interventions. It is not entirely clear whether extended ACT treatments are more advantageous than briefer interventions. Conclusions: There are few studies about the effectiveness of ACT on CPSS. However, ACT seems to reduce subjective CPSS symptoms and improve the health-related quality of life of these patients. The absence of studies on the effectiveness of ACT in CTTH, IC, and TMD, indicate the pressing need for further ACT studies in these CPSS.
Glycoside Hydrolases and Non-Enzymatic Glycation Inhibitory Potential of Viburnum opulus L. Fruit—In Vitro Studies

Phytochemicals of various origins are of great interest for their antidiabetic potential. In the present study, the inhibitory effects against carbohydrate digestive enzymes and non-enzymatic glycation, antioxidant capacity, and phenolic compounds composition of Viburnum opulus L. fruits have been studied. Crude extract (CE), purified extract (PE), and ethyl acetate (PEAF) and water (PEWF) fractions of PE were used in enzymatic assays to evaluate their inhibitory potential against α-amylase with potato and rice starch as substrate, α-glucosidase using maltose and sucrose as substrate, the antioxidant capacity (ABTS, ORAC and FRAP assays), antiglycation (BSA-fructose and BSA-glucose model) properties. Among four tested samples, PEAF not only had the highest content of total phenolics, but also possessed the strongest α-glucosidase inhibition, antiglycation and antioxidant activities. UPLC analysis revealed that this fraction contained mainly chlorogenic acid, proanthocyanidin oligomers and flavalignans. Contrary, the anti-amylase activity of V. opulus fruits probably occurs due to the presence of proanthocyanidin polymers and chlorogenic acids, especially dicaffeoylquinic acids present in PEWF. All V. opulus samples have an uncompetitive and mixed type inhibition against α-amylase and α-glucosidase, respectively. Considering strong anti-glucosidase, antioxidant and antiglycation activities, V. opulus fruits may find promising applications in nutraceuticals and functional foods with antidiabetic activity.
Orientational Fluctuations and Bimodality in Semiflexible Nunchucks

Semiflexible nunchucks are block copolymers consisting of two long blocks with high bending rigidity jointed by a short block of lower bending stiffness. Recently, the DNA nanotube nunchuck was introduced as a simple nanoinstrument that mechanically magnifies the bending angle of short double-stranded (ds) DNA and allows its measurement in a straightforward way [Fygenson et al., Nano Lett. 2020, 20, 2, 1388–1395]. It comprises two long DNA nanotubes linked by a dsDNA segment, which acts as a hinge. The semiflexible nunchuck geometry also appears in dsDNA with a hinge defect (e.g., a quenched denaturation bubble or a nick), and in end-linked stiff filaments. In this article, we theoretically investigate various aspects of the conformations and the tensile elasticity of semiflexible nunchucks. We analytically calculate the distribution of bending fluctuations of a wormlike chain (WLC) consisting of three blocks with different bending stiffness. For a system of two weakly bending WLCs end-jointed by a rigid kink, with one end grafted, we calculate the distribution of positional fluctuations of the free end. For a system of two weakly bending WLCs end-jointed by a hinge modeled as harmonic bending spring, with one end grafted, we calculate the positional fluctuations of the free end. We show that, under certain conditions, there is a pronounced bimodality in the transverse fluctuations of the free end. For a semiflexible nunchuck under tension, under certain conditions, there is bimodality in the extension as a function of the hinge position. We also show how steric repulsion affects the bending fluctuations of a rigid-rod nunchuck.
Subfoveal Choroidal Thickness and Treatment Outcomes of Intravitreal Aflibercept for Branch Retinal Vein Occlusion

We aimed to investigate the relationship between subfoveal choroidal thickness (SCT) and treatment outcomes of intravitreal aflibercept (IVA) for macular edema (ME) due to branch retinal vein occlusion (BRVO). We retrospectively evaluated 46 patients with treatment-naive BRVO-ME who underwent IVA treatment between March 2016 and February 2017. There was no significant difference in visual acuity within 6 months (0.29 ± 0.20 vs. 0.27 ± 0.19, p = 0.338), the mean central foveal thickness improvement (332.0 ± 162.2 μm vs. 303.9 ± 166.6 μm, p = 0.492), and the mean number of IVA injections (1.7 ± 0.7 vs. 1.6 ± 0.7 times, p = 0.658) between the SCT thickened (n = 26 patients, 26 eyes) and SCT non-thickened groups (n = 20 patients, 20 eyes). The rate of ME recurrence was significantly lower in the SCT decreased group (6/17 eyes (35.2%) vs. 19/30 eyes (63.3%); p = 0.038). In conclusion, pretreatment choroidal thickening does not affect the therapeutic effect of IVA for BRVO, but ME recurrence was lower in cases of treatment-related choroidal thinning. Thus, changes in SCT may be a therapeutic indicator of IVA for acute BRVO.
Effects of Dietary Calcium Propionate Supplementation on Hypothalamic Neuropeptide Messenger RNA Expression and Growth Performance in Finishing Rambouillet Lambs

The objective of this experiment was to evaluate the effects of feeding different levels concentrations of dietary calcium propionate (CaPr) on lambs’ growth performance; ruminal fermentation parameters; glucose–insulin concentration; and hypothalamic mRNA expression for neuropeptide Y (NPY), agouti-related peptide (AgRP), and proopiomelanocortin (POMC). Thirty-two individually fed lambs were randomly assigned to four treatments: (1) control diet (0 g/kg of CaPr), (2) low CaPr, (30 g/kg dry matter (DM)), (3) medium CaPr, (35 g/kg DM), and (4) high CaPr (40 g/kg DM). After 42 days of feeding, lambs were slaughtered for collecting samples of the hypothalamus. Data were analyzed as a complete randomized design, and means were separated using linear and quadratic polynomial contrast. Growth performance was not affected (p ≥ 0.11) by dietary CaPr inclusion. The ruminal concentration of total volatile fatty acids (VFA) increased linearly (p = 0.04) as dietary CaPr increased. Likewise, a linear increase in plasma insulin concentration (p = 0.03) as dietary CaPr concentration increased. The relative mRNA expression of NPY exhibited a quadratic effect (p < 0.01), but there were significant differences in the mRNA expression of AgRP and POMC (p ≥ 0.10). Dietary calcium propionate did not improve lamb growth performance in lambs feed with only forage diets. Intake was not correlated with feed intake with mRNA expression of neuropeptides.
An Autoencoder-Based Deep Learning Approach for Load Identification in Structural Dynamics

In civil engineering, different machine learning algorithms have been adopted to process the huge amount of data continuously acquired through sensor networks and solve inverse problems. Challenging issues linked to structural health monitoring or load identification are currently related to big data, consisting of structural vibration recordings shaped as a multivariate time series. Any algorithm should therefore allow an effective dimensionality reduction, retaining the informative content of data and inferring correlations within and across the time series. Within this framework, we propose a time series AutoEncoder (AE) employing inception modules and residual learning for the encoding and the decoding parts, and an extremely reduced latent representation specifically tailored to tackle load identification tasks. We discuss the choice of the dimensionality of this latent representation, considering the sources of variability in the recordings and the inverse-forward nature of the AE. To help setting the aforementioned dimensionality, the false nearest neighbor heuristics is also exploited. The reported numerical results, related to shear buildings excited by dynamic loadings, highlight the signal reconstruction capacity of the proposed AE, and the capability to accomplish the load identification task.
Supplementary material: Truly shift-invariant convolutional neural networks

that satisfy Y a 0 (0) = Y a 1 (0). Azulay and Weiss pointed out in [1] that the sum-shift invariance obtained via antialiasing is lost due to the action of non-linear activation functions like ReLU in convolutional neural networks. They postulated that this happens through the generation of high-frequency content after applying ReLU. We elaborate on this phenomenon here and also show that high frequencies alone do not provide a full picture.
Psychometric Properties and Factor Invariance for the General Health Questionnaire (ghq-28): Study in Peruvian Population Exposed to the Covid-19 Pandemic

Large-scale epidemics are known to significantly disrupt the mental health and perceived wellbeing of most populations. In spite of the wide range of screening tools, there are not many reliable and widespread tools for the identification of psychological symptoms in non-clinical populations during a health crisis. Objective: The aim of this study was to conduct a psychometric analysis of the Goldberg's GHQ- 28, through a sample of Peruvian adults by using a confirmatory factor analysis. Materials and Methods: 434 individuals have been examined, studying the goodness and structure of the Goldberg GHQ-28 questionnaire. Result: We found high reliability indicating optimal values (Cronbach a=0.829), also there are four correlated factors that show strict invariance among the 28 items. Confirmatory factor analysis (CFA) and exploratory factor analysis ( EFA) were used to examine the structure of the subscales. There are high levels of anxiety (X=1.01) and social dysfunction (X= 1.21) in the assessed sampling. Conclusion: The factorial structure obtained in this study is similar to that originally described by the researchers involved in the original questionnaire. It is concluded that GHQ-28 is suitable to explore prevalence of psychopathologies in sanitary emergency contexts for general non-psychiatric population.
Triple Band Antenna Design for Bluetooth, WLAN and WiMAX Applications

—A novel and compact tri-band planar antenna for 2.4/5.2/5.8-GHz wireless local area network (WLAN), 2.3/3.5/5.5-GHz Worldwide Interoperability for Microwave Access (WiMAX) and Bluetooth applications is proposed and studied in this paper. The antenna comprises of a L-shaped element which is coupled with a ground shorted parasitic resonator to generate three resonant modes for tri-band operation. The L-shaped element which is placed on top of the substrate is fed by a 50 Ω microstrip feed line and is responsible for the generation of a wide band at 5.5 GHz. The parasitic resonator is placed on the other side of the substrate and is directly connected to the ground plane. The presence of the parasitic resonator gives rise to two additional resonant bands at 2.3 GHz and 3.5 GHz. Thus, together the two elements generate three resonant bands to cover WLAN, WiMAX and Bluetooth bands of operation. A thorough parametric study has been performed on the antenna and it has been found that the three bands can be tuned by varying certain dimensions of the antenna. Hence, the same design can be used for frequencies in adjacent bands as well with minor changes in its dimensions. Important antenna parameters such as return loss, radiation pattern and peak gains in the operating bands have been studied in detail to prove that the proposed design is a promising candidate for the aforementioned wireless technologies. 1
WORKING PAPER SERIES Smooth Robust Multi-Horizon Forecasts

We investigate whether smooth robust methods for forecasting can help mitigate pronounced and persistent failure across multiple forecast horizons. We demonstrate that naive predictors are interpretable as local estimators of the long-run relationship with the advantage of adapting quickly after a break, but at a cost of additional forecast error variance. Smoothing over naive estimates helps retain these advantages while reducing the costs, especially for longer forecast horizons. We derive the performance of these predictors after a location shift, and confirm the results using simulations. We apply smooth methods to forecasts of U.K. productivity and U.S. 10-year Treasury yields and show that they can dramatically reduce persistent forecast failure exhibited by forecasts from macroeconomic models and professional forecasters.
The impact of chronic pain on driving behaviour: a systematic review.

ABSTRACT Driving is a complex task that requires both the ability to rapidly identify potential hazards and to respond appropriately to driving situations to avoid crashing. A great deal of research has sought to increase road safety by focusing on risky behaviours, very few of which have explored the effects of chronic pain on driving behaviour. This systematic review aimed to assess driving behaviour and motor vehicle crash risk in drivers with chronic pain. Four databases (Embase, PubMed, Scopus, and PsycINFO) were searched using relevant search terms. From 8543 studies, 22 studies met the eligibility criteria for inclusion in this review. A driving behaviour framework, based on the Michon model of driving behaviour, is proposed to map the effect of chronic pain on driving behaviour. Findings suggest that drivers with chronic pain engage in risk-compensatory strategies that are positive from a precautionary perspective. However, there is considerable variability in the use of such strategies across different samples, suggesting that there are significant barriers and facilitators involved in these decisions. Moreover, our findings provide some evidence that chronic pain could increase crash risk and changes in driving behaviour among drivers. Evidence-based recommendations for practitioners and policymakers are proposed regarding the risks of driving in individuals experiencing chronic pain. Future research into chronic pain in driving could benefit from having a unified evidence-based approach to determine behaviour at all levels of the driving task.
Crystalline Mixed Phase (Anatase/Rutile) Mesoporous Titanium Dioxides for Visible Light Photocatalytic Activity

The high photocatalytic activity of mixed phase (80% anatase and 20% rutile) titanium dioxide (Degussa P25) has attracted a great deal of interest in recent years. However, its low efficiency in visible light and nonporous nature limits the potential use and capabilities. Here, we report a novel preparation method for crystalline, thermally stable (up to 800 °C) TiO2 materials with tunable anatase/rutile phase compositions (0–100%) and monomodal mesoporosity. The control of the phase compositions was achieved by framework vanadium doping and various applied heat treatments. Vanadium (0% to 10% doping) decreased the anatase–rutile transformation temperature (from 1000 to 600 °C) and shifted the absorption band to the visible light region (narrowed the band gap). The mesopore structure was preserved in mixed phase TiO2. These materials are members of the recently discovered University of Connecticut (UCT) mesoporous materials family. The UCT materials are randomly packed nanoparticle aggregates and mesopore.