Miracle-dz/UniFAR-FTUs huggingface dataset:
Sitagliptin: A literature review on analytical and bio-analytical methods

This review work is a collective data of previously published methods related to the analysis of Sitagliptin either in alone or in combination with other drugs. Many spectroscopic methods like derivative techniques, chromogenic techniques were used for. Newly developed as well as improved chromatographic method also available by using biological fluids and pharmaceutical formulations. Apart from these two techniques few LC-MS/MS and HPTLC methods also available. Now in this present analytical research world quality by design or design by expert technique is used to get improved method for method validation. This concise review work can guide an analyst to choose most appropriate method for a best analytical method development and validation.
Effects of sunlight exclusion on leaf gas exchange, berry composition, and wine flavour profile of Cabernet-Sauvignon from the foot of the north side of Mount Tianshan and a semi-arid continental climate

Canopy shading is a widely used viticultural strategy for mitigating early grape berry ripening caused by global warming. In this study, we covered half of the canopy with a black shade cloth from the pea-size stage to harvest. In the fruit zone, canopy shade treatment (ST) reduced daily average solar radiation by about 74.6 % compared to the untreated control (UC), and significantly reduced daily average temperature. ST leaves were found to have lower net assimilation rates and higher internal CO2 concentration than in UC, which resulted in reduced yield, bunch weight, cane starch and berry total soluble solids. A delayed development stage was found in ST berries which had lower pH and higher titratable acid than UC. ST increased both berry and wine anthocyanin concentration while significantly decreasing flavonol concentration. ST wines had higher concentrations of a number of ester compounds and β-damascenone than UC wines, thus significantly enhancing the floral and fruity aroma of ST wines. Higher C6/C9 and fatty acids concentrations in ST berries may have caused higher ester concentrations in ST wines. The results showed significant effects on metabolites in berries and wines caused by canopy shade.
DYNAMIC WACC: RE-ENRICHMENT OF DISCOUNTED CASH FLOW VALUATION TECHNIQUE

The current and widely used traditional Discounted Cash Flows (“DCF”) valuation technique implements constant Weighted Average Cost of Capital (“WACC”) as discount factor in estimating the company’s value. However, previous studies in firms’ financing behavior have shown that the implementation of constant WACC is not applicable to real finance practice. Moreover, the recent studies in finance have highlighted the importance of internal financing towards the financing behavior and WACC of the company. In this study, the researcher would like to introduce new DCF valuation technique which implements the dynamic WACC rather than the constant one by emphasizing on the impact of a firm’s internal financing capability in accordance to Pecking Order Theory. Based on the Root Mean Square Error (“RMSE”) and Standard Error (“SE”) indicated by the statistical analysis from eight public-listed non-financing companies from various industry sectors in Indonesia Stock Exchange, the implementation of the dynamic WACC has better accuracy in estimating the company’s value as indicated by the share price, aligned with the Pecking Order Theory. Future research should develop and enrich the currently implemented traditional DCF valuation technique from other dimensions, such as the Free Cash Flows and the Terminal Value.
Compact Dual Broadband Planar Slot Antenna For Wireless LAN Application

A new compact dual broadband planar slot antenna that covers two frequency bands of 2.4GHz and 5.2GHz for modern mobile broadband wireless network applications is presented. The antenna structure includes folded self-resonance meander slots as the main radiators, and using the CPW-fed combined with a coupling mechanism at its feeding input to match the large input impedance exhibits at the input of the slot antenna. The use of meander slot together with the coupling CPW-fed feeding network enables us to reduce the antenna size, the manufacturing complexity as well as the operating bandwidth. The antenna is manufactured using the FR4 print circuit board and the results show the wanted characteristics and performance.
The apical membrane protein podocalyxin acts as an anti-adhesin in epithelial ovarian carcinoma

Podocalyxin is a heavily sialylated and sulfated integral membrane protein with anti-adhesive properties that contributes to apical domain formation in normal, polarized epithelial cells. Immunohistochemical analysis of an outcome-linked ovarian tumour microarray (TMA) revealed that podocalyxin was expressed in the majority of lesions but showed no significant correlation with poor outcome. Podocalyxin expression was most prevalent in serous tumours where it was often apically localized in low-grade welldifferentiated tumours. In the normal ovary, podocalyxin expression was moderate and localized to the free peritoneal surface of normal ovarian surface epithelia (OSE), serving to distinguish the OSE from its underlying stroma. Interestingly, podocalyxin was apically localized in dysplastic, columnar OSE suggesting that it may serve as a marker of polarity early in the carcinogenic process. After characterizing podocalyxin expression in a variety of ovarian carcinoma cell lines, OVCAR-3, a low podocalyxin expressing cell line, was forced to overexpress the mouse podocalyxin cDNA. Forced overexpression of podocalyxin did not disrupt cellcell junctions in polarized monolayers. However, it did disrupt cohesive cell-cell aggregation in suspension. In addition, podocalyxin overexpression in depolarized monolayers disrupted celhsubtratum adhesion. Podocalyxin overexpression caused a marked decrease in cell adhesion to fibronectin, mesothelial cells and to anti-pi integrin antibody-coated wells, suggesting that high levels of podocalyxin may interfere with integrin engagement. To investigate the consequences of podocalyxin overexpression on P1 integrin localization in polarized monolayers and 3D cell clusters, dual immunofluorescence staining was performed for podocalyxin/p 1 integrin. Podocalxyin overexpressing monolayers targetted podocalyxin to the apical membrane, resulting in a subtle depletion of P1 integrin from this site. In non-polar 3D cultures, podocalyxin overexpressing cell clusters mislocalized podocalxyin to the cell-matrix interface causing P1 integrin depletion from this membrane domain. Therefore, as a cell-ECM disrupting anti-adhesin, mislocalized podocalyxin may promote the dissemination of primary tumour nodules into the peritoneal cavity by interfering with integrin engagement at the tumounECM interface.
Geochemical Distribution of Trace Elements in Groundwater from the North Mara Large‐Scale Gold Mining Area of Tanzania

The influence of large‐scale mining operations on groundwater quality was investigated in this study. Trace element concentrations in groundwater samples from the North Mara mining area of northern Tanzania were analyzed. Statistical analyses for relationships between elemental concentrations in the samples and distance of a sampling site from the mine tailings dam were also conducted. Eleven trace elements (Al, As, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, and Zn) were determined, and averages of Fe and Al concentrations were higher than levels accepted by the Tanzanian drinking water guideline. Levels of Pb in three samples were higher than the World Health Organization (WHO) and United States Environmental Protection Agency (USEPA) drinking water guidelines of 10 and 15 µg/L, respectively. One sample contained a higher As level than the WHO and USEPA guideline of 10 µg/L. The correlation between element concentrations and distance from the mine tailings dam was examined using the hierarchical agglomeration cluster analysis method. A significant difference in the elemental concentration existed depending on the distance from the mine tailings dam. Mann–Whitney U‐test post hoc analysis confirmed a relationship between element concentration and distance of a sampling site from the mine tailings dam. This relationship raises concerns about the increased risks of trace elements to people and ecosystem health. A metal pollution index also suggested a relationship between elemental concentrations in the groundwater and the sampling sites’ proximity from the mine tailings dam.
Guillain‐Barré syndrome

Acute Inflammatory polyneuropathies are an important group of neuromuscular disorders and are referred to collectively as Guillain-Barre syndrome (GBS). Our knowledge regarding pathogenesis, diagnosis and management continues to expand, resulting in improved opportunities for identification and treatment. These autoimmune processes cause neuropathy by affecting various structures (myelin or axons), at different locations (nerve root, nerve cell bodies or peripheral nerve) with a variety of patterns. Most clinical neurologists will be involved in the management of patients with these disorders, and there are now a variety of reasonable therapies available for acquired demyelinating neuropathies. In this report, we review the distinctive clinical, laboratory and electro-diagnostic features that aid in their diagnosis, with emphasis on clinical characteristics that are of paramount importance in diagnosing specific conditions and determining the most appropriate therapies, and helpful in determining long-term prognosis.
THE EFFECT OF METAL OXIDES ON THE REFINERY EFFLUENT TREATMENT

Metal Oxides (Titania TiO 2 , and Calamine (ZNO)) have been used as tertiary treatment for Refinery Effluent treatment and wastewaters to comply with the regulatory discharge limits and to oxidize persistent compounds that had not been oxidized in the biological treatment. The wastewater was provided by the Bandar Abbas Refinery. Although BOD removal is high in this plant, a residual and persistent COD (Chemical Oxygen Demand), besides a somewhat high phenol content remains. Three catalysts were tested TiO2 (Aldrich), ZnO (Aldrich), and TiO 2 (P25, Degussa) by the UV radiation, the third being the most active. The optimized conditions obtained with an experimental design were 3.0 (g/L) TiO 2 and pH=6.3. The use of hydrogen peroxide (H 2 O 2 ) showed no beneficial effect. Removal of 93% of phenols, 56% of dissolved organic carbon (DOC), and more than 50% of oil and grease (OG) were achieved in the catalytic process with UV radiation, improving the quality of the treated wastewater.
Citation Analysis of Research Papers of Faculty and Research Scholars of University of Mysore to Assess the Individual’s Research Productivity and Impact of Authors

Bibliographical details of research papers and papers citing them were analyzed to indentify the productivity and performance of faculty and research scholars of University of Mysore. Findings show Authors of University of Mysore have collaborated with most of the developed countries in the world. USA has the highest collaborative works followed by Japan. Further, Researcher has also attempted to know the publication productivity per author. Study revealed that publication productivity per author for 806 collaborative research papers is 0.1810.
Diseño e implementación de un filtro adaptativo para deconvolución en sistemas OPSODIS

The general objective of the project is to equalize a room that uses an OPSODIS system to reproduce binaural audio, seeking to achieve an optimal perception by the listener by eliminating the influence on the system of reflected energy. To do this, an adaptive filter is designed making use of a Least Mean Square (LMS) algorithm, in order to be able to cancel the annoying reflections for the listener. Objectively and subjectively, the modification of the sweet spot of the system and the level of affect of the interaction of the OPSODIS system with the room in the position of the receiver is evaluated
Exploiting Rich Syntax for Better Knowledge Base Question Answering

Recent studies on Knowledge Base Question Answering (KBQA) have shown great progress on this task via better question understanding. Previous works for encoding questions mainly focus on the word sequences, but seldom consider the information from syntactic trees.In this paper, we propose an approach to learn syntax-based representations for KBQA. First, we encode path-based syntax by considering the shortest dependency paths between keywords. Then, we propose two encoding strategies to mode the information of whole syntactic trees to obtain tree-based syntax. Finally, we combine both path-based and tree-based syntax representations for KBQA. We conduct extensive experiments on a widely used benchmark dataset and the experimental results show that our syntax-aware systems can make full use of syntax information in different settings and achieve state-of-the-art performance of KBQA.
On the electrode configurations in a large single phase liquid xenon detector for dark matter searches

In the near future there will be the request for very large liquid Xenon (LXe) detectors for Dark Matter (DM) searches in the 50-ton range. To avoid an impractically long, single drift space of a dual-phase detector, it seems beneficial to use the single-phase technique. Since electrons then can drift in any direction, we can segment the homogeneous medium and thus avoid an excessive maximum drift path of order 4 m. The shorter detector length has several benefits, e.g. requiring a lower cathode voltage for the same drift field. We can easily split the TPC into two regions with the cathode in the center and two anodes at the top and bottom. One also can use multiple TPCs stacked on top of each other in the same liquid volume to reduce the maximum drift length even further. A further division of the drift space by installing an additional anode in the center would require S2 photons to traverse the liquid for several times the Rayleigh scattering length in LXe, which is only 30–40 cm. This seems to be excessive for good x-y localization. We therefore suggest a geometry of two independent TPCs with two drift spaces each. Despite earlier publications concerns persisted about the effect of shadowing. A detailed FEM model of the anode regions shows that with an aligned wire arrangement the drifting electrons impinge sideways on the anode in a narrow angular range of width 15°–20°. Most S2 photons are emitted in full view of the close-by PMT array. About 37% of the S2 photons are shadowed by the anode wire out of which 30% will be reflected back again on the gold plating of the wires. Thus we can observe 74% of the total S2 light. Compared to a dual-phase detector, however, we do not suffer from the extraction efficiency, sometimes reported as low as 50%.
Regular Ideals of Locally-Convex Higher-Rank Graph Algebras

We give a vertex set description for basic, graded, regular ideals of locally-convex Kumjian-Pask Algebras. We also show that Condition (𝐵) is preserved when taking the quotient by a basic, graded, regular ideal. We further show that when a locally-convex, row-finite 𝑘 -graph satisfies Condition (𝐵) , all regular ideals are graded. We then show the same things hold for gauge-invariant, regular ideals in locally-convex 𝑘 -graph 𝐶 ∗ -algebras.
Seeing and Believing: Evaluating the Trustworthiness of Twitter Users

Social networking and micro-blogging services, such as Twitter, play an important role in sharing digital information. Despite the popularity and usefulness of social media, there have been many instances where corrupted users found ways to abuse it, as for instance, through raising or lowering user’s credibility. As a result, while social media facilitates an unprecedented ease of access to information, it also introduces a new challenge - that of ascertaining the credibility of shared information. Currently, there is no automated way of determining which news or users are credible and which are not. Hence, establishing a system that can measure the social media user’s credibility has become an issue of great importance. Assigning a credibility score to a user has piqued the interest of not only the research community but also most of the big players on both sides - such as Facebook, on the side of industry, and political parties on the societal one. In this work, we created a model which, we hope, will ultimately facilitate and support the increase of trust in the social network communities. Our model collected data and analysed the behaviour of 50,000 politicians on Twitter. Influence score, based on several chosen features, was assigned to each evaluated user. Further, we classified the political Twitter users as either trusted or untrusted using random forest, multilayer perceptron, and support vector machine. An active learning model was used to classify any unlabelled ambiguous records from our dataset. Finally, to measure the performance of the proposed model, we used precision, recall, F1 score, and accuracy as the main evaluation metrics.
Light-ring pairs from 
A
-discriminantal varieties

When geodesic equations are formulated in terms of an effective potential U , circular orbits are characterised by U = ∂aU = 0. In this paper we consider the case where U is an algebraic function. Then the condition for circular orbits defines an A-discriminantal variety. A theorem by Rojas and Rusek, suitably interpreted in the context of effective potentials, gives a precise criteria for certain types of spacetimes to contain at most two branches of light rings (null circular orbits), where one is stable and the other one unstable. We identify a few classes of static, spherically symmetric spacetimes for which these two branches occur.
The hypersimplex canonical forms and the momentum amplituhedron-like logarithmic forms

In this paper we provide a formula for the canonical differential form of the hypersimplex Δ k,n for all n and k. We also study the generalization of the momentum amplituhedron Mn,k to m = 2, which has been conjectured to share many properties with the hypersimplex, and we provide counterexamples for these conjectures. Nevertheless, we find interesting momentum amplituhedron-like logarithmic differential forms in the m = 2 version of the spinor helicity space, that have the same singularity structure as the hypersimplex canonical forms.
Global well-posedness of z-weak solutions to the primitive equations without vertical diffusivity

In this paper, we consider the initial boundary value problem in a cylindrical domain to the three dimensional primitive equations with full eddy viscosity in the momentum equations but with only horizontal eddy diffusivity in the temperature equation. Global well-posedness of z-weak solution is established for any such initial datum that itself and its vertical derivative belong to L. This not only extends the results in [8] from the spatially periodic case to general cylindrical domains but also weakens the regularity assumptions on the initial data which are required to be H there.
Modeling Flooding Extent Due To Hurricane Floyd In The Coastal Plains Of North Carolina

In this article two modeling approaches were developed based on the use of US Geological Survey digital elevation model (DEM) data. These models were utilized to delineate the extent of flooding induced by precipitation from Hurricane Floyd in a portion of Pitt County, North Carolina. The patterns of flood extent derived from the two models were compared to the extent of flooding indicated on a digital aerial photograph taken two days after peak flood levels had been reached. In addition, floodplain boundaries based on Federal Emergency Management Agency Q3 maps were compared to the extent of flooding on the aerial photo. Actual emergency response operations undertaken through the Pitt County Emergency Operations Center during the flood event are described, and are used to provide a context for evaluating the potential utility of these models. The flood extents produced by the modeling methods performed well at representing the actual extent of the flooding. Colby, J.D. , Mulcahy, K.A. , and Wang, Y. (2000). Modeling Flooding Extent Due to Hurricane Floyd in the Coastal Plains of North Carolina. Global Environmental Change Part B: Environmental Hazards, 2(4):157-168. (Dec 2000) Published by Elsevier (ISSN: 1464-2867). DOI:10.1016/S1464-2867(01)00012-2 Colby, J.D. , Mulcahy, K.A. , and Wang, Y. (2000). Modeling Flooding Extent Due to Hurricane Floyd in the Coastal Plains of North Carolina. Global Environmental Change Part B: Environmental Hazards, 2(4):157-168. (Dec 2000) Published by Elsevier (ISSN: 1464-2867). DOI:10.1016/S1464-2867(01)00012-2 Modeling flooding extent from Hurricane Floyd in the coastal plains of North Carolina Jeffrey D. Colby, Karen A. Mulcahy, and Yong Wang
Coarse-Grained Stochastic Model of Myosin-Driven Vesicles into Dendritic Spines

We study the dynamics of membrane vesicle motor transport into dendritic spines, which are bulbous intracellular compartments in neurons that play a key role in transmitting signals between neurons. We consider the stochastic analog of the vesicle transport model in [Park and Fai, The Dynamics of Vesicles Driven Into Closed Constrictions by Molecular Motors. Bull. Math. Biol. 82, 141 (2020)]. The stochastic version, which may be considered as an agent-based model, relies mostly on the action of individual myosin motors to produce vesicle motion. To aid in our analysis, we coarse-grain this agent-based model using a master equation combined with a partial differential equation describing the probability of local motor positions. We confirm through convergence studies that the coarse-graining captures the essential features of bistability in velocity (observed in experiments) and waiting-time distributions to switch between steady-state velocities. Interestingly, these results allow us to reformulate the translocation problem in terms of conditional mean first passage times for a run-and-tumble particle moving on a finite domain with absorbing boundaries at the two ends. We conclude by presenting numerical and analytical calculations of vesicle translocation.
Evaluation of Human-AI Teams for Learned and Rule-Based Agents in Hanabi

Deep reinforcement learning has generated superhuman AI in competitive games such as Go and StarCraft. Can similar learning techniques create a superior AI teammate for human-machine collaborative games? Will humans prefer AI teammates that improve objective team performance or those that improve subjective metrics of trust? In this study, we perform a single-blind evaluation of teams of humans and AI agents in the cooperative card game Hanabi, with both rule-based and learning-based agents. In addition to the game score, used as an objective metric of the human-AI team performance, we also quantify subjective measures of the human's perceived performance, teamwork, interpretability, trust, and overall preference of AI teammate. We find that humans have a clear preference toward a rule-based AI teammate (SmartBot) over a state-of-the-art learning-based AI teammate (Other-Play) across nearly all subjective metrics, and generally view the learning-based agent negatively, despite no statistical difference in the game score. This result has implications for future AI design and reinforcement learning benchmarking, highlighting the need to incorporate subjective metrics of human-AI teaming rather than a singular focus on objective task performance.