Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical Application of the HCM-AF Risk Score in the Prediction of Clinical Outcomes of Polish Patients with Hypertrophic Cardiomyopathy

The recently introduced HCM-AF Risk Calculator allows the prognosis of atrial fibrillation (AF) occurrence in hypertrophic cardiomyopathy (HCM) patients. The aim of this study was to assess the clinical application of the HCM-AF Risk Score in the prediction of the clinical outcomes of Polish patients. The study included 92 patients (50.0% female, median age 55 years), with a baseline sinus rhythm diagnosed between 2013 and 2018. The analysis involved the incidence of clinical characteristics and outcomes, total mortality, rehospitalisation, and the course of heart failure (HF). According to the HCM-AF Risk Score, the HCM population was stratified into three subgroups, with a low (13/14.2%), intermediate (30/32.6%), and high risk of AF (49/53.2%). Subgroups differed significantly: the high-risk subgroup was older, had a higher body mass index (BMI), and more advanced signs of left ventricular (LV) hypertrophy and left atrium (LA) dilatation. The registered AF incidence was 31.5% and 43.5% in the 2- and 5-year follow-ups, and it was significantly higher than in the HCM-AF Risk Score population, which had 4.6% in the 2-year follow-up, and 10.7% in the 5-year follow-up. In the whole population, the AF incidence in both the 2- and 5-year follow-ups revealed a strong correlation with the HCM-AF Risk Score (r = 0.442, p < 0.001; r = 0.346, p < 0.001, respectively). The clinical outcomes differed among the subgroups: the total mortality was 15.4% vs. 20.0% vs. 42.9% (p < 0.05); rehospitalisation was 23.1% vs. 53.3% vs. 71.4% (p < 0.05). The highest HF progression was in the high-risk subgroup (36.7%). Regardless of the high results of the HCM-Risk Score in Polish patients, the score underestimates the real-life high level of AF incidence. The HCM-AF Risk Score seems to be useful in the prediction of the general clinical outcomes in HCM patients.
Confidence estimation of the covariance function of stationary and locally stationary processes

Summury In this note we consider the problem of confidence estimation of the covariance function of a stationary or locally stationary zero mean Gaussian process. The constructed confidence intervals are based on the usual empirical covariance estimate and a special estimate of its variance. The results about coverage probability are stated in a nonasymptotic way and apply for small and moderate sample size under mild conditions on the model. The presented numerical results are in agreement with the theoretical issues and demonstrate applicability of the method.
Energy Exchange between the Mesoscale Oceanic Eddies and Wind-Forced Near-Inertial Oscillations

AbstractIn this study, the energy exchange between mesoscale eddies and wind-forced near-inertial oscillations (NIOs) is theoretically analyzed using a slab mixed layer model modified by including the geostrophic flow. In the presence of strain, there is a permanent energy transfer from mesoscale eddies to NIOs forced by isotropic wind stress. The energy transfer efficiency, that is, the ratio of the energy transfer rate to the near-inertial wind work, is proportional to , where S2 is the total strain variance, is the effective Coriolis frequency, and ζ is the relative vorticity. The theories derived from the modified slab mixed layer model are verified by the realistic numerical simulation obtained from a coupled regional climate model (CRCM) configured over the North Pacific. Pronounced energy transfer from mesoscale eddies to wind-forced NIOs is localized in the Kuroshio Extension region associated with both strong near-inertial wind work and strain variance. The energy transfer efficiency in anticyclo.
The role of nutrition and oxidative stress as aging factors in Caenorhabditis elegans

The molecular mechanism of aging, which has been a “black box” for many years, has been elucidated in recent years, and the nematode C. elegans, which is a model animal for aging research, has played a major role in its elucidation. From the analysis of C. elegans longevity-related mutant genes, many signal transduction systems, with the insulin/insulin-like growth factor signal transduction system at the core, have emerged. It has become clear that this signal transduction system is greatly affected by external nutrients and is involved in the downstream regulation of oxidative stress, which is considered to be one of the main causes of aging.
Role of V-pits in the performance improvement of InGaN solar cells

We study the influence of V-pits on the overall conversion efficiency of bulk In0.12 Ga0.88N based heterojunction solar cells grown by MOVPE. We show that V-pits significantly enhances the extraction of the photogenerated carriers in the InGaN absorber, resulting in a peak external quantum efficiency of 79% and a short circuit current density (twice the state of the art) of 2.56 mA/cm−2 under AM 1.5G conditions.
The discrete modified Novikov-Veselov hierarchy and discrete dierential geometry

The Weierstrass representation associates to each solution of the Dirac equation a surface in three-dimensional space, and any surface locally admits such a description. This description has recently been proposed as a possible approach to the Willmore conjecture. Discrete differential geometry is a new field which aims to find the discrete equivalents of notions and methods of smooth surface theory [2]. Recently, the discrete analogues of many interesting geometries associated with integrable systems have been found. We consider the problem of constructing an integrable discretization of the Dirac operator and the associated modified Novikov-Veselov hierarchy, and of finding the correct discrete analogue of the Weierstrass representation. The standard method consists in first discretizing the auxiliary spectral data and the linear operators. The spectral data associated to the differential Dirac operator is an algebraic curve with two marked points and exponential singularities at those points. To construct the discretization, we replace each exponential singularity with a pair of meromorphic singularities. We find that the appropriate discrete analogue of the differential Dirac operator is the following difference operator T2ψ1 = αψ1 + βψ2 T1ψ2 = βψ1 + αψ2
Review on effects of plant densities and nitrogen fertilization on sesame (Sesamum indicum L.) Yield and yield components

Sesame is the most ancient oil seed used by man and it is considered as one of the most important oil crop. Sesame is an erect annual plant of numerous types and varieties two basic sesame types are usually distinguished; long-season, occasionally treated as perennials. Seeds are rich source of edible oil (48-55%) and protein (20-28%). The optimum soil condiotion for sesame is well-drained, loose, fertile and sandy alluvial soils that have a pH value between 5.4 and 6.7. This review is required to review the effects of plant density and nitrogen fertilization on yield and yield components of sesame. Nitrogen is the most important essential nutrient in plant nutrition. When rate of nitrogen fertilizer increased, yield and yield components of sesame also increased in some extent except oil contents. Oil contents of crops are decreased when nitrogen rate is increased. Maximum yield of sesame is achieved from the best spatial arrangement of plants for effective canopy development, water and nutrient utilization and pest control increasing plant density by decreasing planting distance b/n plants increased plant height, height of the first fruiting branch. These results are due to higher competition among plants for light and results the elongation of internodes. Decreasing plant population by increasing distance b/n plants increased number of branches, capsules/plant, 1000-seed weight and seed weight/plant. Increasing plant population density decreases seed yield and oil content of seed per plants and increases seed yield and oil yield/ha, due to the greater number of sesame plants per unit area.
A Modularized Design for Output Synchronization of LTI Dynamical Networks with Communication Delays

: In this paper, we address output synchronization for a network of heterogeneous agents with linear time invariant single-input-single-output dynamics in the presence of communication delays. To this end, we present a three-stage modularized design procedure: (i) a parallel feedforward compensator is designed to convert the dynamics to a minimum-phase system with relative degree one, (ii) the resulting system is then transformed into a feedback equivalent to a passive system, and (iii) the agents are interconnected based on a passivity-based output synchronization law. The beneﬁt of the present control scheme is that not only implementation but also the design stage of the controller is distributed, namely the agents do not need to know the entire network structure. The present solution is then shown to achieve output synchronization. We ﬁnally demonstrate the present controller through simulation.
Solusi Heuristik untuk Permasalahan Rute Inventori Berkala pada Produk Segar

Produk segar yang mudah rusak (perishable) ialah produk yang mengalami penurunan nilai seiring dengan waktu sehingga dibutuhkan strategi pendistribusian dan penyimpanan yang tepat agar produk dapat terjual sebelum nilai produk menurun secara signifikan. Pada riset ini dikembangkan suatu metode solusi heuristik bagi masalah inventory routing berkala untuk pendistribusian dan pengelolaan persediaan produk segar mudah rusak dengan tujuan memaksimalkan pendapatan total yang dihasilkan. Pengembangan metode solusi heuristik ini menggunakan dua algoritma heuristik yaitu greedy dan random. Eksperimen terhadap kedua algoritma ini dilakukan menggunakan dua skenario pola demand konsumen akhir. Hasil eksperimen menunjukkan bahwa Algoritma Greedy mampu memberikan solusi yang lebih baik dibandingkan dengan Algoritma Random pada skenario pola demand menurun.
Sens pracy pedagogicznej a poczucie sprawstwa nauczycieli – szkolnych liderów. Relacja z pierwszej fazy projektu Erasmus+ Getting Heads Together

The Meaning of Pedagogical Work and the Teachers’- School Leaders’ Agency: a Summary of the First Phase of the Getting Heads Together Erasmus+ Project. The aim of the article is to present and to summarize the first phase of the Getting Heads Together (GHT) project, implemented under the Erasmus+ program in cooperation with seven institutions from five European countries. The aim of the project is to develop a transformational model for school leadership development, on the basis of which a school leadership development program will be created to support school leaders’ sense-making capability, a subject that has not been sufficiently included in school leadership developmental programs so far. The article briefly introduces the basic categories on which the development program will be based and their understanding in the context of the GHT projectIt indicates those elements of school reality addressed by the GHT project that may be related to teachers’ agency and self-efficacy.
CONSTRUCTION OF COMPOSITE INDEX OF LEADING INDICATORS FOR FDI CYCLE FOR BRICS ECONOMIES.

Dinesh Kumar Choudhury 1 and Rajendra Narayan Paramanik 2 . 1. Assistant Professor, Department of Economics, Sri Sathya Sai Institute of Higher Learning Prasanthi Nilayam515 134, Andhra Pradesh, India. 2. Assistant Professor, Department of Economics & Finance, BITS Pilani, Pilani Campus, Vidya Vihar333031, Rajasthan, India. Manuscript Info Abstract . Manuscript History
THE BENEFICIAL IMPACTS OF ADDING EXTRA VIRGIN OLIVE OIL ON GROWING RABBITS DURING THE HOT SUMMER SEASON OF EGYPT.

: Ninety six growing rabbits at 6 weeks of age with an average initial body weight of 655.15 ± 5.92, g were randomly divided into four equal groups, 24 rabbits per each group (6 replicates in each group). The first group received a basal diet without extra virgin olive oil (EVOO) and served as a control. The other three groups were fed the basal diet supplemented with 0.2, 0.4 and 0.6% EVOO /kg diet groups, respectively. The traits studied were growth performance, blood biochemical constituents, carcass, and digestion and economic efficiency of the growing rabbits under hot summer season of Egypt. The present results showed that the final body weight (FBW) and feed conversion ratio (FCR) were enhanced significantly (P≤0.05) by 10.96 % and 9.40 % respectively, in the group fed diet supplemented with 0.6% extra virgin olive oil 0.6% EVOO as compared with the control group. Hot carcass weight, dressing, and total non-carcass fat (%) were significantly (P≤0.05) improved for growing rabbits fed diets supplemented with
Evaluation of diffraction effects of phase contrast imaging on HL-2A and HL-2M tokamak

Diffraction effects of diagnostic windows and a phase plate are evaluated in sets of phase contrast imaging (PCI) systems on HL-2A tokamak. Results show that wave field of an incident laser with shorter wavelength is less effected by diffraction. The diameter of viewing windows for PCI is asked to be larger than 50 mm to eliminate diffraction effect, implying the defection of the traditional PCI diagnostic with 10.6 μm CO2 laser based on the viewing port with an inner diameter of 35 mm. This investigation promises a remarkable anti-diffraction performance for PCI diagnostics on the constructing HL-2M tokamak, which reserves a pair of diagnostic windows with an inner diameter of 80 mm. Evaluation of response to the phase plate indicates that the signal response and the laser beam width are restricted by each other. A suitable choice of laser beam width depends on the specific plasma physics.
Consensus Problem with a Reference State for Fractional‐Order Multi‐Agent Systems

In this paper, the consensus problem of fractional‐order multi‐agent systems with a reference state is studied under fixed directed communication graph. At the beginning, the convergence speeds of fractional‐order multi‐agent systems are investigated based on the Mittag‐Leffler function. Then, a common consensus control law and a consensus control law based on error predictor are proposed, and it is shown that the consensus tracking can be achieved using the above control laws when a communication graph has a directed spanning tree. Finally, the convergence speeds of fractional‐order systems are compared, and it is discovered that the convergence of systems is faster using the control law based on error predictor than using the common one.
Ki67 Index in Patnaik Grade 2/Kiupel Low-Grade Canine Cutaneous Mast Cell Tumors with Early Lymph Node Metastasis: A Descriptive Study

Simple Summary Patnaik grade 2/Kiupel low-grade (G2/LG) represent the majority of diagnosed canine cutaneous mast cell tumors (cMCTs), with a reported incidence of 53.6–57.6%. It has been reported that a variable percentage of dogs (3–17%) with G2/LG die from tumor-related causes; therefore, it could be hypothesized that a subset of G2/LG tumors could manifest an aggressive behavior. Ki67 and mitotic count (MC) are the two most investigated proliferation markers in cMCTs. However, different Ki67 cut-offs have been proposed by previous studies, and have always been assessed in cMCTs of different histological grade in heterogeneous canine populations; moreover, the lymph nodes’ (LNs) metastatic status has never been included. This retrospective study investigated the usefulness of the Ki67 index in predicting cMCT behavior in a homogeneous cohort of G2/LG with HN2 LNs. Thirty-nine dogs with primary G2/LG cMCTs and HN2 LNs treated with surgery alone were enrolled. The results of the present study report that all dogs treated with surgery alone had a good prognosis; no local, nodal or distant metastasis occurred in the timespan considered, and the Ki67 index did not have prognostic impact. Abstract Several studies evaluating Ki67 in canine cutaneous mast cell tumors (cMCTs) have reported its prognostic value when tumors of all histological grades are included. This study aims to evaluate whether the Ki67 index has a predictive value in a homogeneous cohort of G2/LG cMCTs with HN2 lymph nodes (LNs) and to describe the clinical outcome. The second goal was to explore the correlation between the Ki67 index and MC. The medical databases of three institutions were retrospectively searched for dogs undergoing surgical treatment for cMCT and LN extirpation, with a histological diagnosis of G2/LG with HN2 LNs. Information about histological margins, MC, Ki67 index, local recurrence, nodal relapse, distant metastasis, de novo cMCT occurrence and date and cause of death were included. A total of 39 cases were identified. None of these developed local and nodal relapse or metastatic distant disease. Median MC was 1 (0–2). Median Ki67 index was 3.5 (0.7–14.3). Ki67 and MC were not significantly correlated. At the end of the study, 32 (82%) dogs were alive, 7 (18%) dogs were dead from unrelated causes and 4 (10.2%) dogs were lost to follow-up. The median ST was not reached, and the mean was 893 days (104–2241 days). Considering the strict inclusion criteria, dogs affected by G2/LG with HN2 LNs treated with surgery alone may have a good oncologic outcome; the Ki67 index does not have prognostic impact.
Surgical Technique for the Latarjet Procedure Using Non-Cannulated Screws

Background: The Latarjet procedure is effective for patients with anterior glenohumeral instability with substantial glenoid bone loss due to its triple blocking effect. Indications: Indications include high-risk patients with recurrent anterior glenohumeral instability with any glenoid bone loss or low-risk patients with 15% to 30% glenoid bone loss. Technique Description: An incision is made lateral to the coracoid and the deltopectoral interval is established. The pectoralis minor is released medially off the coracoid and the coracoacromial (CA) ligament is released close to the acromion. The coracoid is cut with a right-angle saw and the inferior coracoid is decorticated with a burr. Two holes are pre-drilled in the coracoid. The subscapularis is split between the upper two-thirds and lower one-third with the arm in external rotation. The capsule is split vertically at the joint line and the humeral head is retracted. The anterior glenoid is decorticated with a burr, and a hole is drilled inferiorly. The depth is measured and added to the depth of the inferior bone block hole. A fully threaded 3.5-mm solid stainless steel screw is placed in the inferior hole. Care is taken to ensure that the lateral border of the bone block is flush with the articular margin. This is repeated for the superior hole. A 1.8-mm knotless suture anchor is placed between the screws. The repair stitch is passed through the capsule and loaded onto the anchor and tensioned. The CA ligament is laid over the capsule and repaired. The subscapularis split is repaired side to side and the wound is closed in layers. Results: High return-to-sport rates, including at the same level of play, have been observed among young competitive athletes with significant glenoid bone loss who underwent a Latarjet, with similarly favorable results in older patients. Ninety-day complication rates have been reported around 9%, 5% of which constituted graft or hardware failures. Discussion/Conclusion: The Latarjet procedure is an effective option for indicated patients with anterior glenohumeral instability and may be enhanced with solid screws, proper anatomic technique, and capsulolabral repair augmentation. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication. Graphical Abstract This is a visual representation of the abstract.
Innovative Aqueous Nanoemulsion Prepared by Phase Inversion Emulsification with Exceptional Homogeneity

Formulating low-solubility or low-permeability drugs is a challenge, particularly with the low administration volumes required in intranasal drug delivery. Nanoemulsions (NE) can solve both issues, but their production and physical stability can be challenging, particularly when a high proportion of lipids is necessary. Hence, the aim of the present work was to develop a NE with good solubilization capacity for lipophilic drugs like simvastatin and able to promote the absorption of drugs with low permeability like fosphenytoin. Compositions with high proportion of two lipids were screened and characterized. Surprisingly, one of the compositions did not require high energy methods for high droplet size homogeneity. To better understand formulation factors important for this feature, several related compositions were evaluated, and their relative cytotoxicity was screened. Optimized compositions contained a high proportion of propylene glycol monocaprylate NF, formed very homogenous NE using a low-energy phase inversion method, solubilized simvastatin at high drug strength, and promoted a faster intranasal absorption of the hydrophilic prodrug fosphenytoin. Hence, a new highly homogeneous NE obtained by a simple low-energy method was successfully developed, which is a potential alternative for industrial application for the solubilization and protection of lipophilic actives, as well as (co-)administration of hydrophilic molecules.
Linkages in business-science cooperation as a driving force of technological innovation in the national economy

Purpose – The purpose of the article is to analyse the importance of linkages and trust in business‑science cooperation. Moreover, the aim is to verify the impact of close business‑science relations on the innovativeness of the national economy. Research method – Literature studies, surveys, FGI (Focus Group Interview) Results – The research confirms the high importance of relations and relationship management in the development of business‑science cooperation. Companies that assess cooperation with science as valuable and significant to innovation, also indicate a high level of mutual relations and related fluidity in the exchange of knowledge. On the other hand, weak relations and low levels of trust often lead to problems in the implementation of joint projects, and, as a result, in the development of innovation. Originality / value / implications / recommendations – The processes of relationship development and trust‑building are as important in business‑science cooperation as the carefully conducted technology transfer. Thus, companies and scientific units engaged in mutual cooperation should pay attention to both of these factors. In macroeconomic terms, the level of relations between representatives of business and science affects the number of innovations created by a given economy. As a result, it also determines its innovativeness.
A Sequence of Upper Bounds for the Perron Root of a Nonnegative Matrix

We present a sequence of progressively better upper bounds for the Perron root of a nonnegative matrix. Each element in the sequence is a function of the Perron root of the arithmetic symmetrization of a power of the matrix. The results complement those of Szyld based on the geometric symmetrization of a power of the matrix. © 1998 Elsevier Science Inc.
Stochastic Analysis of Noncompliance with Drug Therapy

When it comes to drugs, a major concern may stem from drug noncompliance [5]. Patient medication compliance is a key factor for the efficacy of any therapy. This paper addresses issues from stochastic analysis of Markov processes for modeling irregular (or variable) compliance settings. The major questions addressed in [2] are associated with the mean and variance of the drug concentration; we suggest that a hybrid stochastic differential system could improve the study established there. To the best of our knowledge, such modeling is quiet novel as regards pharmacokinetics and pharmacodynamics. c ©2011 World Academic Press, UK. All rights reserved.