Miracle-dz/UniFAR-FTUs huggingface dataset:
Rapid Detection of the Biomarkers for Carcinoid Tumors by a Water Stable Luminescent Lanthanide Metal–Organic Framework Sensor

Serotonin (5‐hydroxytryptamine, HT), a neurotransmitter, and its main metabolite 5‐hydroxyindole‐3‐acetic acid (HIAA) are biomarkers for carcinoid tumors. They can be quantitatively detected by a new luminescent sensor based on a water stable lanthanide metal–organic framework (Ln‐MOF). This Ln‐MOF features a (3,4)‐connected topology containing 1D channels occupied by lattice water molecules. Luminescent studies reveal that high luminescence quenching efficiency occurs upon the addition of HT and HIAA. The Ln‐MOF also displays excellent sensitivity with fast response within 1 min, good reusability, and detection limits as low as 0.66 and 0.54 × 10−6m for HT and HIAA, respectively. In addition, the sensing function exhibits excellent selectivity even in the presence of other neurotransmitters and the main coexisting species in blood plasma and urine.
Effects of psychological intervention on rehabilitation outcomes in patients with spinal cord injury; a systematic review

Introduction: Psychological issues are common in patients with spinal cord injury (SCI) which negatively affects rehabilitation outcomes. Therefore, early psychological interventions are as important as physical rehabilitation. The aim of the study was to systematically review literature regarding the effects of psychological interventions on rehabilitation outcomes in patients with SCI. Material & Methods: A systematic review was conducted according to the PRISMA guidelines. Literature was searched in PubMed and PEDro databases. Articles published in English language from earliest record to August 2020 were searched. Observational and interventional studies which assessed effects of different psychological interventions on rehabilitation outcomes in patients with SCI were included. Review articles, editorials, short communications and conference papers were excluded. Quality assessment of the interventional studies was assessed using PEDro scale while methodological quality of the observational studies was carried out using NIH quality assessment tools. Results: On the basis of eligibility criteria, 13 studies were included. Out of the total studies, 11 were observational studies and the remaining 2 were interventional studies. The included studies reported that psychological interventions improve rehabilitation outcomes such as functional independence, community participation and quality of life. Conclusion: Psychological treatment is an effective complement to physical rehabilitation interventions to improve functional status of patients with SCI.
Evaluation of some Rice Genotypes (Oryza sativa L.) Under Normal and Heat Stress Conditions تقييم تراکيب وراثية مختلفه من الأرز تحت الظروف الطبيعية والإجهاد الحراري

The aim of the current study was to evaluate 25 rice genotypes under normal at Sakha, Kafr ElSheikh, Egypt and under heat stress conditions at New Valley, Egypt during two rice growing seasons of 2017 and 2018. Data were collected on eight traits i.e., flag leaf area, flag leaf angle, plant height, panicle length, panicles plant, 1000-grain weight, fertility percentage and grain yield plant. High amount of genetic variation was found among the studied genotypes under normal and heat stress conditions. All studied genotypes were negatively affected by high temperature. The most affected traits by heat stress were fertility percentage, grain yield plant, flag leaf area and panicles plant with average reductions of 73.59, 64.22, 42.46 and 41.31%, respectively. Correlation and path coefficient analysis showed that number of panicles plant and fertility percentage were good indicators for grain yield under heat stress condition. Based on the HSI values of grain yield plant and fertility percentage, both genotypes N22 and Giza178 could be identified as heat tolerant (HSI value was ≤0.5 for both traits). Based on the results of PCA analysis, the most desirable genotypes under heat stress were Giza178, N22, Bala, Dular, WAB56104, Sakha104 and Egyptian Yasmin. According to the current investigation, it could be concluded that those eight genotypes could be used in breeding programs as donors for developing high yielding heat tolerant promising lines. In addition, Egyptian rice varieties; Giza178, Sakha104 and Egyptian Yasmin are suitable for cultivating under both normal and heat stress conditions in Egypt.
Stress and Burnout among Egyptian Undergraduate Medical Students

Background: Medical study often carries a great load on the medical students that may result in different affections on their life. Objectives: To assess the prevalence of stress and burnout and the influencing factors that may contribute to them among the Egyptian medical undergraduate students and to determine the most influencing stressors in the pre-clinical and clinical stages of education. Method: A cross-sectional study was conducted on 320 undergraduate Egyptian medical students in the Zagazig and Menoufia faculties of medicine. The participants were interviewed through a questionnaire of four parts. The first part was about their sociodemographic characteristics, the second part was to assess their perceived level of stress by the 12-item General Questionnaire (GHQ-12), The level of burnout was assessed through the Maslach Burnout Inventory (MBI) in the third part, and stress and burnout influencing factors were assessed through a predesigned questionnaire in the fourth part. Results: This study showed a worrisome prevalence of stress (84.7%) and burnout (45.6%) among undergraduate medical students. On studying stress, the students in the clinical stage of education were exposed more to stress and burnout (P-value 0.007, <0.001). The most stressing factors were being in clinical education, having a personal illness or disability that may affect their academic performances, and worry about the future career. Conclusion: High prevalence of stress and burnout is disconcerting. There were many triggering factors found that should be reconsidered.
SHORT TERM EFFECT OF LAPAROSCOPIC SLEEVE GASTRECTOMY ON TYPE 2 DIABETIC MORBID OBESE PATIENTS

Background: Obesity is a medical condition in which excess body fat has accumulated to extend that it may has an adverse effect on health. Leading to reduction of life expectancy or increasing health problems. Objective: To evaluate the improvement in plasma glucose level and lipid profile in type 2 diabetes mellitus obese patients after Laparoscopic Sleeve Gastrectomy (LSG). Patients and methods: This prospective study was conducted at Surgery Department, Al-Azhar University Hospitals during the period between December 2019 and August 2020. Study included 30 cases of type 2 diabetes mellitus morbidly obese patients (with BMI ≥35 Kg/m2) and all of them had failed in trials of conservative management including dietary control, and they were bulky eater but non sweet eater. Laparoscopic sleeve gastrectomy technique was done for all cases. Results: Our result showed that there was a significant improvement of the HbA1c measured at three and six months post-operatively. Five patients (17%) completely cured from T2DM, while 12 patients (40%) became pre-diabetic, and 13 patients (43%) remained diabetic with great improvement of their previous follow up of HbA1c. Conclusion: LSG was efficient in the remission and/or improvement of symptoms of T2DM and other obesity-related comorbidities, with a significant reduction in serum HbA1c and lipid profile.
A review: Antimicrobial activity of the medicinal spice plants to cure human disease

Since the ancient time medicinal plants and spices are used as herbal medicine because of their medicinal values. They are the valuable resources of the natural antimicrobial compounds used to treat the infectious disease caused by bacteria and other pathogens. Plant’s extract, essential oil and numerous kinds of secondary compounds had antibacterial, antiviral, antifungal and antioxidants activities with less or no toxic effects; that are essential to cure many diseases. The compounds isolated from the medicinal spice plants show antimicrobial activity against some bacterial strains that has the ability to affect the food quality and shelf life of the food. These plants have various medicinal properties like anti-inflammatory action, tonic, expectorants, diuretics, astringents, digestives, carminative, antibiotics and stimulants etc. The spectrum of compounds present in medicinal spice plants, and the structure of major compounds discussed in this review, are responsible for all of their medicinal properties. Therefore, plants are used in the form of maceration, fluid extracts, oil, syrup, juice, decoction, powder, tea and ointments. In the terms of the frequencies and configuration of various radicals both medicinal plants and antibiotics are different. Since plant-based products have no toxicity, also less costly than conventional drugs, research on the compounds found in medicinal plants and their action against harmful microbial species should be conducted in order to improve human health and expand the use of medicinal plants. Plants also have the ability to inhibit or alter protein-protein interactions, making them a powerful modulator of signal transduction, apoptosis, mitosis and immune response.
1504-Article Text-7247-1-11-20210524.docx

Depression is a global health crisis which becomes increasingly urgent as depression rates continue to rise. While impressive progress has been made in understanding and treating depression, we face many more unknowns, and existing treatment options are not effective for all patients and all depressive episodes. In recent years, the microbiota-gut-brain axis has emerged as a promising research direction as increasing evidence shows the gut microbiota and the brain to be closely linked. This review presents the most compelling evidence for a bidirectional relationship between the gut microbiota and the brain, zooms in to examine putative neural, neuroimmune, neuroendocrine, and neurometabolic mechanisms involved in bottom-up communication, reviews existing evidence for probiotics, and discusses challenges and future directions of the field. Further research on the microbiota-gut-brain axis could provide a better understanding of the pathogenesis of depression and reveal opportunities for novel preventions and treatments.
VHRM_A_317859 407..414

Internal Medicine, Agaplesion Bethesda Hospital, Wuppertal, Germany Purpose: Atrial fibrillation (AF) is the most common arrhythmia and is associated with an increased risk of complications. A screening test has the potential to prevent AF-related complications. This study investigated the diagnostic accuracy of an automated device for home blood pressure (BP) monitoring, which implements an algorithm for AF detection. Patients and Methods: A modified, automated oscillometric device for home BP monitoring (Omron BP785N (HEM-7321-Z), Omron Healthcare) with an AF detector was used to measure the BP in patients. During each BP measurements, the electrocardiogram (ECG) was recorded simultaneously. Simultaneous BP measurements and ECG recordings were obtained from 99 subjects. Results: Twenty out of 20 patients with atrial fibrillation were correctly recognized by the device and the device correctly identified 67 patients with sinus rhythm as “Not-AF”. On the other hand, 12 patients with basic rhythm: sinus rhythm were incorrectly referred to as “atrial fibrillation”. In summary, the device has a diagnostic accuracy of 87.88% with a sensitivity of 100% and a specificity of 84.8%. On the other hand, in 23 patients, the raw data of the device showed that a body movement occurred during the measurement of the blood pressure. If these subjects were excluded of the analysis, then the diagnostic accuracy of the device would be even better, namely 90.79%. The sensitivity would be 100% and the specificity 89.5%. Conclusion: These data suggest that an automated device for home blood pressure has an excellent diagnostic accuracy for detecting an AF and could be used as a reliable screening test for early diagnosis of atrial fibrillation. Body movements have an impact of the accuracy and specificity of a blood pressure monitor.
Management Research and Practice

Increasing the statutory minimum wage in most SEE economies, in the same time represents an increase in the main source of income, and providing a higher level of welfare for workers. However, in some SEE countries, despite the unsuitable economic indicators, and the slow recovery from the economic crisis, a sharp increase in the minimum wage is observed. The increase in these countries contributes to the growing part of the workers who receive minimum wage, which additionally burdens the economic system. In addition, the increase of the minimum wage should not be a substitute for the improvement of the conditions on the labor market and the labor market institutions, as well as the insignificant increase of the labor productivity that persistently fails to catch up with the increase of the labor productivity in Western Europe countries. In the previous period, on the example of Bulgaria, Romania, Croatia, North Macedonia, Albania and Serbia, there was a significant increase in the level of the statutory minimum wage. These countries, as economies in which in the previous period the highest rate of increase of the minimum wage was observed, will be the subject of research. Hence, a relationship analysis was conducted between the statutory minimum wage and labour productivity, using a panel-regression model. The countries are divided in two groups: non-EU member countries (North Macedonia, Albania and Serbia) and EU member countries (Bulgaria, Romania and Croatia). These groups are formed according to specific economic criteria (level of GDP and labour mobility) and non-economic criteria (EU membership). The aim of the paper is to discover the correlation and causal relationship between an increase in the statutory minimum wage and labour productivity. The results provide an indicative picture of how governments set the minimum wage, the extent of their increasing, and whether the increase in the minimum wage is to some extent related to the increase in labor productivity. The results indicate that in the first group of countries (North Macedonia, Albania and Serbia) the relationship between statutory minimum wage and labour productivity is strong and positive. Contrary, this relationship is weak and negative in the countries from the second group (Bulgaria, Croatia and Romania). The correlation analysis results are consistent with the estimates from the panel – regression.
Serum biochemical reference ranges for pregnant sheep

Late pregnancy is accompanied by dramatic changes in the metabolism of sheep, in which the nutrient requirements increase and the metabolic capacity of ewes is under severe stress due to the rapid foetal growth and development of the mammary gland. The blood metabolic profile can be used to monitor these alterations, which can lead to metabolic disorders such as pregnancy toxaemia. However, data available on serum parameters in sheep do not consider physiological state. Therefore, the present study aimed to determine the biochemical reference ranges for pregnant ewes, including serum energy, protein and enzyme-related metabolites. Data from a variety of metabolites were obtained from experiments performed in several institutions and commercial farms using Santa Inês, Dorper, Lacaune, Morada Nova, Bergamacia and Suffolk ewes reared under different conditions (grazing, feedlot, semi-feedlot, collective and/or individual pens, and metabolic cages) from 2006 to 2017. All animals were healthy and without feed restriction. Data from ewes with any clinical manifestations were removed. The metabolic energy profile included data of glucose, cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein and very-low-density lipoprotein levels; the metabolic protein profile included the metabolites total protein, uric acid, urea, albumin, and creatinine; and the metabolic enzymatic profile included the enzymes aspartate aminotransferase, gamma-glutamyl transferase and alkaline phosphatase. The reference ranges were estimated using the software RefVal 4.11. Dixon’s test was used to identify and remove outliers. The confidence intervals and percentiles were estimated using the nonparametric method of bootstrap when data were not normally distributed. A 95% confidence level was used. The serum biochemical reference ranges for pregnant sheep determined in our study were strongly divergent from those established by one of the most cited books on the topic, especially considering the high serum urea and cholesterol concentrations and low levels of blood glucose observed. Therefore, it is essential to consider physiological status when evaluating the blood metabolic profile of pregnant ewes in order to maintain an adequate nutritional management and to prevent health disorders that may lead to productive and reproductive losses.
New technology, trade unions and the future: not quite the end of organised labour

This paper outlines different dimensions and historical features of the debate regarding worker organisations and the question of new technology at work. There has always been a tension between pessimistic views that highlight the difficulties established trade unions have had when responding to the use of new technologies by employers. However, there are a range of developments that suggest that trade unions and, also, broader networks of workers are responding to the introduction of new technology in terms of their use of regulation through the courts, for example, and innovative forms of bargaining as well as new forms of mobilisation, new forms of worker organisation, and innovative forms of communication. What is more, there are alternative legacies highlighting that worker responses to technological change is more complex and innovative although how these have evolved is another matter.
Acquired Left Ventricular to Right Atrial Shunt (Gerbode′s Defect) after Aortic Valve Replacement: Case Report

Background: Left ventricular to right atrial (LV—RA) shunt is an unusual type of ventricular septal defect (VSD). Acquired LV—RA shunts may be due to complications of cardiac operation, endocarditis, trauma or myocardial infarction. A previous cardiac operation is the most common cause. The diagnosis of LV—RA communication is not easy, and it should be remembered in patients who do not recover normally. Diagnosis can be confirmed with ultrasound or magnetic resonance image (MRI) or multi-slice CT. Surgical correction is usually the treatment of choice, but closing the communication percutaneously should be considered as an option. Objective: Aim of this case presentation was to show the clinical scenario of a rare post-operative complication (after aortic valve replacement). Patient and methods: Male patient aged 35 years, during hospital admission in the CCU post-operative after aortic valve replacement was complaining of dyspnea, orthopnea, paroxysmal nocturnal dyspnea and by echocardiographic examination revealed Gerbode defect, not improved by modification of medical treatment necessitating cardiothoracic surgery consultation who recommend conservative treatment and follow up if the patient still symptomatic surgical repair versus percutaneous closure could be done. Conclusion: Acquired left ventricular to right atrium shunt (Gerbode′s defect) can result from septal trauma after valve replacement, infective endocarditis, or myocardial infarction. In addition to the usual causes of cardiac decompensation following aortic valve surgery, one should consider the possibility of a left-to-right shunt secondary to an iatrogenic left ventricular-right atrial communication, particularly if either septal trauma or extensive valvular calcification was encountered during the surgical procedure.
The Gamification Design for Affordances Pedagogy

in which we perceive environments to support the needs of learners in the educational system. The main questions are how gamification elements can influence student engagement to improve their affordances. Affordance behavior is a human behavior that refers to a mindset; an attitude or opinion, especially a habitual one. Motivational activities can change a learner's behavior. A skill-based mindset can be created through the use of affordance motivation. Affordance refers to the points, badges, and leaderboards in gamification elements. This research aims to improve the affordance mindset design of interactive systems with gamification. The affordance design will improve the pedagogy related to engagement. The research focuses on the mindset factors and the relationship between the factors that promote the desired learning outcomes. The findings may help in designing the gamification affordance design method for affordance pedagogy. The expected model could improve learners' affordances and instructional activities.
Levothyroxine Administration Timing in Hypothyroidism Patients

Levothyroxine is a synthetic T4 hormone that is biochemically and physiologically identical to the natural hormone, and it is used when the body is deficient in the natural hormone. This study was conducted to summarize the current evidence that compare evidence supporting morning dose to evening dose of levothyroxine in patients with hypothyroidism‎. A simple systematic review was carried out, searching databases PubMed, Google Scholar, and EBSCO. The authors extracted the needed data. There is conflicting data regarding effectiveness of morning dose versus evening dose in management of levothyroxine. More studies reported effectiveness of bedtime dose more than breakfast dose in hypothyroidism management. Numerous studies reported effectiveness of bedtime dose more than breakfast dose in hypothyroidism management. The most resent evidences recommended that, if possible, L‐T4 be consistently taken either 60 minutes before breakfast or at bedtime (3 or more hours after the evening meal), for optimal, consistent absorption.