Miracle-dz/UniFAR-FTUs huggingface dataset:
EFFECT OF HISTONE DEACETYLASE INHIBITORS ON POST-IMPLANTATION DEVELOPMENT OF CLONED BOVINE EMBRYO

Production of cloned bovine has many practical applications in medicine and agriculture, although low efficiency has still been the main problem. This challenge has resulted from improper epigenetic reprogramming of donor's nuclear such as histone acetylation and zygotic gene activation that does not occur correctly. Conventionally, only one histone deacetylase inhibitor (HDACi) was used once after activation to improve the cloning efficiency, but the results were still low. In this study, a new approach of using HDACi was applied to improve the cloning efficiency: Combination of two HDACis TSA and Scriptaid (SCR); and treatment with HDACis for two-step during the activation time and the time of zygotic gene activation. Their effects on pre-implantation and postimplantation development of cloned bovine embryos were examined. The results showed that the SCR-combined group had a higher cloned bovine blastoformation rate than the untreated and One-step treatment group. Furthermore, after transferring to the surrogate cow, the embryos in the SCR-combined group also showed a higher capacity to develop beyond 210 days. In conclusion, this study found that treatment of cloned embryos with combination of TSA and Scriptaid for two steps treatment increased the preimplantation and postimplantation development of cloned bovine embryos. Messenger RNA Expression Patterns Bovine Embryos Derived from Procedures Their Implications for Development. Tóm tắt. T ạ o ra bò nhân b ả n vô tính có r ấ t nhi ề u ứ ng d ụ ng th ự trong nông nghi ệ p m ặ c dù t ỉ l ệ thành công th ấ p v ẫn đang là mộ t v ấn đề quan tr ọ ng n gi ả i quy ế t. V ấn đề này là k ế t qu ả c ủ a l ỗ i tái t ậ p trình bi cho như là histone acetyl hóa, ho ạt độ ng c ủ a gen h ợ p t ử (ZGA). Ch ứ histone acetyl hóa (HDACi) đã đượ c s ử d ụ ng nh ằ m c ả i thi n ỉ phát tri n phôi bò nhân b ả n nhưng kế t qu ả v ẫ n còn th ấ p. Trong nghiên c ứ u cách s ử d ụ ng HDACi m ới đượ c áp d ụ ng bao g ồ m k ế t h ợ p hai lo ạ i HDACi Scriptaid và TSA, và x ử lý HDACi trong hai bướ c vào lúc kích ho ạ t t ế bào tr ứ ng và vào lúc ZGA. Ả nh hưở
R-Loop Formation in Meiosis: Roles in Meiotic Transcription-Associated DNA Damage

Meiosis is specialized cell division during gametogenesis that produces genetically unique gametes via homologous recombination. Meiotic homologous recombination entails repairing programmed 200–300 DNA double-strand breaks generated during the early prophase. To avoid interference between meiotic gene transcription and homologous recombination, mammalian meiosis is thought to employ a strategy of exclusively transcribing meiotic or post-meiotic genes before their use. Recent studies have shown that R-loops, three-stranded DNA/RNA hybrid nucleotide structures formed during transcription, play a crucial role in transcription and genome integrity. Although our knowledge about the function of R-loops during meiosis is limited, recent findings in mouse models have suggested that they play crucial roles in meiosis. Given that defective formation of an R-loop can cause abnormal transcription and transcription-coupled DNA damage, the precise regulatory network of R-loops may be essential in vivo for the faithful progression of mammalian meiosis and gametogenesis.
Clustering and Multidimensional Scaling for Individual Difference Extraction

- This paper proposes methods to obtain difference among subjects by using the degree of reliability of each subject based on the results of fuzzy clustering and multidimensional scaling (MDS). In addition, new fuzzy clustering and MDS, including the weights of reliability scores, are proposed to classify subjects. When we observe data consisting of values of objects with respect to variables, and such data are observed over multiple subjects, capturing the difference among subjects is important in many fields. In this paper, the degree of reliability is obtained through the optimality of convex clustering. Based on this idea, it is shown that the same difference over the subjects can be obtained, regardless of the difference in obtained latent structures, which are the result of dynamic fuzzy clustering and the result of MDS by a numerical example. From this, we show the robustness of the proposed reliability concerning the variety of the obtained latent structures of data.
Paediatric gastrointestinal endoscopy: Experience in Red Cross War Memorial Children’s Hospital, Cape Town, South Africa

Background. Endoscopy is an important diagnostic and therapeutic mode of management in children with gastrointestinal disorders. Objective. To determine the indications, endoscopic yields and impact of the service on the ongoing health and complications among children who underwent gastrointestinal endoscopy at Red Cross War Memorial Children’s Hospital, Cape Town. Methods. A 10-year (2007 - 2016) retrospective study of children <18 years old who underwent gastrointestinal endoscopy was undertaken using relevant patients’ variables obtained from their hospital medical records. Data were analysed using Stata 13.1 (p<0.05). Results. A total of 402 children underwent a total of 695 gastrointestinal endoscopic procedures: 592 (85.2%) were gastroscopies, 78 (11.2%) combined gastroscopies with colonoscopies and 25 (3.6%) colonoscopy-only procedures, respectively. The main diagnostic indications for gastroscopy, gastroscopy combined with colonoscopy and colonoscopy-only were chronic abdominal pain (n=49; 12.2%), suspected inflammatory bowel disease (n=30; 7.5%) and rectal bleeding (n=13; 52.0%) respectively. The most common therapeutic indication for gastroscopy was change of a percutaneous endoscopic gastrostomy (n=143; 35.6%) while for colonoscopy 6 (5.8%) had polypectomy. Abnormal histopathological results were made from both macroscopically normal- and abnormal-looking tissues, though with no statistically significant relationship. Conclusion. Endoscopy offers diagnostic and therapeutic options in children. Positive histological findings were obtained in some cases where gastrointestinal mucosae appeared normal. There is need to obtain biopsies from both macroscopically normal- and abnormallooking gastrointestinal mucosae as positive histological findings could be made from them and hence improve diagnostic yield.
Predistortion-Based Linearization for 5G and Beyond Millimeter-Wave Transceiver Systems: A Comprehensive Survey

The next-generation (5G/6G) wireless communication aims to leapfrog the currently occupied sub-6 GHz spectrum to the wideband millimeter-wave (MMW) spectrum. However, MMW spectrums with high-order modulation schemes drive the power amplifier (PA) at significant back-off, causing severe nonlinear distortions, thus deteriorating the transceiver’s (TRXs) modulation process. Typically, the TRX efficacy is quantified with standardized linearization matrices, which take advantage of different predistortion (PD) schemes to handle deep compression of the PA. In this regard, TRX baseband signals are mostly linearized in the digital domain, where digitally controlled linearization needs higher sampling rates due to increasing MMW bandwidths to compensate for intermodulation (IMD) products, resulting in increased system cost and power consumption. Alternately, the digitally controlled analog-based linearization, i.e., the hybridization of digital predistortion (DPD) and analog predistortion (APD), is highly productive and cost-effective for fulfilling the linearized energy-efficient design vision of MMW networks. Therefore, this paper puts an extensive spotlight on the progress in PD-based linearization for 5G and beyond communications. It first provides background information on the advancements of PD schemes through recent surveys, then classifies the general roadmap of PD waveform processing across the TRX system models as preliminary. After this, we present three prominent PD architectures and their design approaches with intrinsic performance metrics. Finally, we explore four case studies encompassing PD operation under certain nonlinear constraints of different communication schemes. We examine the suitability of PD-based linearization solutions, both existing and proposed till the first quarter of 2022, and identify the potential prospects in this domain.
Clinical Characteristics and Potential Mechanisms in Patients with Abnormal Liver Function Indices and Elevated Serum IgG4

Objective We analyzed the etiological classification and clinical characteristics of patients with abnormal liver function indices and elevated serum IgG4 levels and investigated the effects of intrahepatic follicular helper T cell (Tfh) infiltration and serum IL-21. Methods Clinical data (age, sex, past history, clinical manifestations, laboratory tests, imaging, diagnosis, and treatment) and etiology of liver injury from 136 patients were analyzed. We compared the general condition, clinical characteristics, and laboratory tests of 19 AIH (autoimmune hepatitis) patients with elevated serum IgG4 levels with those of 20 AIH patients with normal serum IgG4 levels admitted at the same time. Five patients with AIH and elevated serum IgG4 levels and five AIH patients with normal IgG4 levels were matched by sex, age, and liver function, and Tfh infiltration in liver biopsy tissues of patients in both groups was determined by immunofluorescence staining. Five AIH patients with elevated serum IgG4 levels were selected for measurement of serum interleukin-21 (IL-21) levels by enzyme-linked immunosorbent assay (ELISA), seventeen AIH patients with normal serum IgG4 were matched by sex, age, and liver function indices, and 29 physically healthy individuals matched by sex and age were selected as the control group. The changes in patients with IgG4-RD and abnormal liver function before and after glucocorticoid treatment were measured. Results Patients (136) with abnormal liver function indices and elevated serum IgG4 levels were diagnosed with liver disease of different etiologies. IgG4-related disease was the most frequent, followed by AIH and malignancy. Abnormal liver function indices with high serum IgG4 were most commonly seen as elevated gamma glutamyl transferase (GGT). The AIH group with elevated serum IgG4 had increased intrahepatic levels of Tfh. IL-21 in AIH patients with elevated IgG4 was higher than in patients with normal IgG4 and healthy controls. Patients (n = 28) with abnormal liver function indices and IgG4-related disease received glucocorticoid therapy for six months, and ALT, AST, ALKP, GGT, TBil, DBil, IgG, IgG4, and IgE were significantly lower after treatment. Conclusions Elevated serum IgG4 was seen in patients with abnormal liver function indices with diverse causes. Tfh infiltration and increased IL-21 production may be related to the pathogenesis of AIH with elevated serum IgG4. Glucocorticoid therapy is effective in patients with abnormal liver function indices and IgG4-related disease. Assessing immune function in patients with abnormal liver function indices and elevated serum IgG4 levels should facilitate diagnosis and treatment of the disease.
The Comparison of the Level of Aggressiveness of Oyama Karate and Mixed Martial Art Fighters

Background: Aggressive behavior is inherent in many sports, especially martial arts. It is usually considered undesirable; nevertheless, in some cases, it can be a motivating factor in a competition. It is important to distinguish types of aggression. The aim of this study was to compare the level of aggressiveness between athletes practicing mixed martial arts (MMA) and Oyama Karate. Methods: In total, 30 Oyama Karate and 30 mixed martial art athletes were asked about their aggressive behavior. The Buss–Perry Aggression Questionnaire was used in the study. Results were statistically analyzed. Results: There were statistically significant differences between the performance of Oyama Karate and MMA athletes (p < 0.001), which occurred in all the types of aggression tested (anger, physical aggression, hostility, and verbal aggression). Hence, the results of the study confirmed the accuracy of the research hypothesis that the level of intensity of aggression is higher in MMA fighters than in full-contact Oyama Karate fighters. Conclusions: Physical aggression was dominant in the evaluated fighters. The greatest difference between both groups of fighters was in verbal aggression, whereas the smallest was in hostility.
Properties and Modification of Bismuth-Layered Structure Ferroelectric Materials and Application in Sports

Bismuth-layered oxides are a very important class of ferroelectric materials. Due to their special structure, they have outstanding features in many aspects, such as high Curie temperature, large spontaneous polarization, polarization stability to temperature, high voltage resistance, low dielectric loss, and excellence. Due to its antifatigue properties, the system is very suitable for applications in nonvolatile random access memory and high-temperature sensors. The purpose of this paper is to study the application of the performance and modification of bismuth-layered ferroelectric materials in sports scientific research. Proposed the combination of new materials and sports scientific research projects. This article uses sample analysis and (the comparative experiment method is a method to compare the experimental group and the control group to illustrate the superiority of the experiment) comparative experiment methods, sets up an experimental group and a control group, summarizes the algorithm rules through the study of the microscopic properties of nanomaterials, and designs a numerical simulation program. The experimental results in this article show that after receiving hyperbaric oxygen recovery in the first week, the heart rate of the experimental group subjects has a significant change, which is significantly lower than the initial value ( p < 0.05 ), from 58.0 to 53.0, The higher pressure oxygen had a very significant drop before recovery, from 62.9 to 53.0. In the second week and the third week, the heart rate index decreased significantly after 1 hour of hyperbaric oxygen recovery ( p < 0.01 ), from 54.3 to 49.3 and 56.1 to 52.4, respectively. After the fourth week of intensity training, the heart rate increased significantly from the initial value ( p < 0.05 ), from 49.6 to 55.2. After 1 hour of hyperbaric oxygen recovery, there was a significant decrease compared with before the hyperbaric oxygen recovery ( p < 0.05 ), dropped from 55.2 to 53.1. Illustrate the success of the experimental results. It also completed the subject of interaction and combination of the performance and modification of bismuth-layered ferroelectric materials in sports scientific research.
Evaluation of the cytological changes of oral mucosal cells in Smokers by using Exfoliative Pap Stain.

Oral cancer is a major public health issue worldwide; it remains a highly lethal anddisfiguring disease. in Iraq little is written regarding the occurrence of oral cancer.The aim of this study is To examine the effect of smoking oral mucosa cytological.Hundred men aged between 40 and 70, comprising 50 smokers and 50 non smokers.Material for exfoliative cytology was collected with a metal spatula from thelateral border of the patient’s tongue and from the floor of the mouth and the sampleswere then submitted for Papanicolaou staining. Then cytologic smears were classifiedaccording to Papanicolaou’s classification. the results of the current study reveals thatthere is a significant association between smoking (number of cigarette smoked perday and the duration of smoking (year) and the occurrence of cytological changes inthe oral mucosa ,p <0.001. and there is a significant association between the age andthe papanicolaou’s classes ,p<0.001.
Assessment of Rotational Anatomy of Distal Femur in Sudanese Population and Its Relevance in Total Knee Arthroplasty

Background: Accurate restoration of normal knee anatomy and alignment is the main goal and objective of knee surgery. In the field of total knee arthroplasty, positioning of the implants in the axial plane is referred to as rotational alignment (Victor et al., 2009). Correct Rotational positioning of femoral and tibial components is critical in total knee arthroplasty (TKA). Failure in implant positioning may result in disproportionate tension on the ligaments, causing complications such as development of pain, stiffness, instability or early loosening of the implant (Aglietti et al., 2008). Objective: This study aims to measure the angular relationships of the distal femoral rotational axis in normal Sudanese population. Material and Methods: Magnetic resonance imaging (MRI) scans of the knees of 148 Sudanese subjects were used to define the axes and angles. 114 of these subjects were males and 34 were females. The posterior condylar angle (PCA), the White-side-zepicondylar angle (W-EP), the condylar twist angle (CTA), and the Whiteside trochlear anteroposterior line—posterior condyle line angle (WAP/PCL) were measured. Results: The mean posterior condylar angle (PCA) is 1.69˚, the mean condylar twist angle (CTA) is 5.64˚, the mean Whiteside-epicondylar angle is 88.98˚ and the mean Whiteside trochlear
The Development and Mechanism of Treatment of Depression

Depression is a serious mental disorder that influence about 280 million people around the world. The risk factors that may cause depression include both genetic and environmental factors. Researchers have been long searching for treatments to depression. Patients with symptoms of depression are always treated by both psychic interventions and medical treatments. Although the underlying pathophysiology of depression is remained unclear, neurotransmitters, including serotonin, dopamine, and norepinephrine, are proved to be related to the symptoms of depression by clinical experiments. The first two antidepressants were iproniazid (classified as a monoamine-oxidase inhibitor), and imipramine (classified as a tricyclic antidepressant) in 1950s. More antidepressants using different mechanisms and with fewer side-effect and safety concerns were developed later. People divided those antidepressants into three categories by the order of development: 1) first-generation antidepressants, 2) second-generation antidepressants, and 3) third-generation antidepressants. Due to immature technology, drugs in the first-generation generally have more serious side-effect, more safety concerns, and more restrictions. Thus, second-generation antidepressants, which typically have less side-effect, are now more common in controlling the symptoms of depression. The third-generation antidepressants are still in development, but designed to be more effective with less side-effect. The paper reviews the medical treatments of depression in the order of these three generations.
Modified priority encoder based hardware efficient N-bit comparator

ABSTRACT Digital Circuits applications are expanding rapidly in modern times because they generate correct signals without errors or interferences. These digital circuits play important roles in data storage operation, as well as the implementation of image processing applications on hardware where the power, speed, and area of an electronic device play a significant role, particularly in the field of modern VLSI technology. The digital comparator with more number of bits plays an important role in image processing applications. In the proposed research paper, an attempt is made to design a speed and area efficient 32-bit comparator. To improve the speed of the comparator a modified priority encoder technique is used. It shows that the area of proposed 32-bit digital comparator consumes 573.73 units which are 20% better than when compared with the conventional comparators and the speed improved by 50% when compared with the Conventional Comparators. The proposed implementation is simulated on the ‘Encounter(R) RTL Compiler RC14.28’.
Slow Motion Matters: A Slow Motion Enhanced Network for Weakly Supervised Temporal Action Localization

Weakly supervised temporal action localization (WTAL) aims to localize actions in untrimmed videos with only weak supervision information (e.g., video-level labels). Most existing models handle all input videos with a fixed temporal scale. However, such models are not sensitive to actions whose pace of the movements is different from the “normal” speed, especially slow-motion action instances, which complete the movements with a much slower speed than their counterparts with a “normal” speed. Here arises the slow-motion blurred issue: It is hard to explore salient slow-motion information from videos at normal speed. In this paper, we propose a novel framework termed Slow Motion Enhanced Network (SMEN) to improve the ability of a WTAL network by compensating its sensitivity on slow-motion action segments. The proposed SMEN comprises a Mining module and a Localization module. The mining module generates mask to mine slow-motion-related features by utilizing the relationships between the normal motion and slow motion; while the localization module leverages the mined slow-motion features as complementary information to improve the temporal action localization results. Our proposed framework can be easily adapted by existing WTAL networks and enable them be more sensitive to slow-motion actions. Extensive experiments on three benchmarks are conducted, which demonstrate the high performance of our proposed framework.
Disturbance Observer-Smith Predictor Compensation-Based Platoon Control with Estimation Deviation

In the research of cooperative adaptive cruise control, the coupling relationship between the communication delay, the following time headway, and the string stability leads to a stringent limit on the minimum allowable following time headway. To deal with this limitation, this paper proposes the Disturbance Observer-Smith Predictor Compensation (DOB-SPC)-based Master-Slave architecture. The SPC is adopted to move the communication delays and actuator delays outside the feedback loop in the Master-Slave architecture. It theoretically realizes decoupling when parameters are estimated accurately and achieves zero-headway-string-stability for arbitrary values of communication delay. Subsequently, the robust performance of SPC with estimation deviation of vehicle model dynamic lag, actuator delay, and communication delay in practical application is discussed through the changing trend of the minimum string-stable time headway. To alleviate this problem, the DOB is designed to compensate for the interference caused by the perturbation of vehicle dynamic parameters and improve the estimation accuracy. The simulation results of a four-vehicular platoon show that the string stability and following accuracy are fully guaranteed by applying the proposed strategy, even with smaller headway in the presence of estimation deviation.