Miracle-dz/UniFAR-FTUs huggingface dataset:
Faulted section identification for DC distribution systems using smart meter data

The potential benefits of direct current (DC) network in low-voltage system promote smart grids and facilitate increasing penetration of distributed generation (DG). Correct identification of faulted section of a distribution network by an automation system reduces power outage time and improves reliability indices of such systems. With the onset of a fault in a DC distribution system, data recorded at an outage management system are used to identify the faulted section. With DG units active in a distribution system, there will be bidirectional power flow and faulted section identification becomes challenging. Using voltage and current data from consumer-end smart meters and the substation, a method is proposed to identify the faulted section in DC distribution system. The Hadamard product of fault-affected sections (obtained from network topology and voltage status matrices) is used to identify the faulted section correctly. Using power systems computer-aided design/electro-magnetic transient design and control simulation, the accuracy of the proposed method is verified for different fault situations including simultaneous faults, fault close to a bus and with rooftop photovoltaic integration to a DC distribution system. The method has the capability to provide information on the fault segment that connects feeder pillar to the consumer end also.
Application Of Substitution Schemes For The Method Of Measuring The Humidity Of Bulk Materials

:The article considers the analysis of a high-frequency humidity meter based on the dielcometric method applied to bulk materials on the example of grain. A capacitive method is described where the controlled product is considered as a dielectric filling the converter, and an equivalent circuit of the converter is generalized, which can be represented as an electrical circuit. The complex permittivity of a nonpolar solid dielectric is analyzed, it is determined by the complex polarizability, and the frequency dependence of the permittivity is determined by the frequency dependencies of the real and imaginary parts of the electronic and ionic polarization, where the metrological and information optimization of the measuring device is described, which reduces to the best allocation of the useful signal. As a result of the application of the substitution scheme, certain features of the humidity conversion of the output signal of a dielcometric high-frequency primary converter arise, which determines a wide, practical continuous spectrum of relaxation time covering the corresponding measurement range.
Venture Capital during an economic downturn

This study aims to investigate how Venture Capital firms are influenced by the economic effects caused by the covid-19 pandemic, particularly how the screening and investing processes, as well as the management of the portfolio companies are affected. A qualitative research methodology was applied where semi-structured interviews were conducted with Venture Capital firms situated in Sweden. A generalized outcome from the Venture Capital firms concludes that the screening processes are taking longer, there are fewer new investments and the management of the portfolio companies is more active, there is in other words a more frequent communication between Venture Capital firms and their portfolio companies. The active management of portfolio companies also consists of forming strategies to cope with the new situation, cut costs and establish new financing. Further, the study shows that a few of the VCs are well-positioned to continue investing during covid-19 and aim to make favorable investments due to lower valuations on startups. What distinguishes these VCs compared to the rest is access to capital and forward-looking investment strategies where substantial funds are allocated to follow up investments of portfolio companies.
Public File Sharing System Using Google Drive

-- Peer-to-peer computing popularly known as P2P, is the sharing of computer resources and services by direct exchange of files between systems. We are proposing a new architecture which overcomes the disadvantages of the existing file sharing systems like DC, Torrent and so on. The proposed system tries to minimize resource consumptionat the user’s side in terms of bandwidth and storage.This paper suggests an approach that improves the limitations of the traditional file sharing approach, it shows us the need of a new system and the risks attached with its implementation.
Crystal Methamphetamine Use Among HIV-Positive Gay And Bisexual Men

This study describes factors associated with methamphetamine initiation in a racially diverse sample of 340 methamphetamine-using, HIV-positive gay and bisexual men. A factor analysis was conducted on reasons for initiation, and four factors were identified: to party, to cope, for energy, and to improve self-esteem. Methamphetamine to party accounted for more than one-third of the variance in the factor analysis. Methamphetamine to cope captured almost 9% of the variance, methamphetamine for energy accounted for approximately 8% of the variance, and methamphetamine for self esteem accounted for approximately 7% of the variance. Regression analyses revealed differential associations between methamphetamine initiation factors and HIV risk behaviours. Methamphetamine for self esteem predicted binge methamphetamine use, while methamphetamine to cope was associated with injecting methamphetamine. Using methamphetamine for energy was associated with number of illicit drugs used and using methamphetamine to party was associated with having a greater number of STIs. These findings suggest that methamphetamine initiation among gay and bisexual men is multifaceted, which could have implications for intervention development
Noncoordinate Translation-Level Regulation of Ribosomal and Nonribosomal Protein Genes in the Escherichia coli trmD Operon

The trmD operon of Escherichia coli contains the genes for the ribosomal protein S16, a 21-kilodalton polypeptide of unknown function, the tRNA(1-methylguanosine)methyltransferase, and the ribosomal protein L19, in that order. As reported elsewhere, the operon is transcribed as a single polycistronic mRNA species, and there is no significant difference in the steady-state amounts of different parts of the mnRNA (A. S. Bystrom, A. von Gabain, and G. 1R. Bjork, submitted for publication). Furthermore, accumulation of all parts of the transcript is altered in a stringently controlled manner upon starvation for valyl-tRNA. Here we show that the rate of synthesis of the trmD operon proteins increased with increasing growth rate and that the amount in steady state, at a specific growth rate (k = 1.0), of the tRNA(1-methylguanosine)methyltransferase was 260 molecules per gene copy, which is about 40 times lower than the amount of the two ribosomnl proteins, whereas the 21-kilodalton protein was synthesized to the amount of about 850 molecules per gene copy, The lower steady-state amount of the two nonribosomal proteins was not due to a higher turnover rate. Synthesis of the 21-kilodalton and TrmD proteins responded differently from that of the two ribosomal proteins during conditions which provoked amino acid starvation, although accumulation of the entire mRNA molecule responds similarly to the rate of synthesis of the two ribosomal proteins. We conclude that the observed differential and noncoordinate expression is achieved by regulation at the level of mRNA translation. The Escherichia
EFFECTS OF OBESITY ON ANESTHESIA

: Background: Studies have shown that obesity among adults is rapidly increasing throughout the world, Due to its associated pathophysiology, obese individuals show varied response to many medication doses, including anesthetics. The effect of obesity on anesthetics is a narrowing of the therapeutic index. Methodology: We conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE, January 1985, through February 2017. The following search terms were used: anesthesia, obesity, airway management for obese patients, pharmacokinetics of anesthetics in obese patients, volume distribution Aim: In this review, we aim to study how obesity affects anesthetic medication and airway management differently. Conclusion: Anesthesia in obese adults needs careful considerations regarding changes in the PK and PD properties of many medications used in anesthesia. Physiological and anthropometric alteration, like increases in cardiac output, alterations in regional blood flow, and elevations in fat mass and lean mass affect PK properties. Additionally, respiratory pathophysiology such as the increased incidence of OSA, and fat deposition in the oropharynx and chest wall change PD characteristics of the anesthetic medications.
A nomogram established by in ammatory markers predicting overall survival after radical resection of gastric cancer

Lixiang Zhang the First A liated Hospital of Anhui Medical University Yezhou Su the First A liated Hospital of Anhui Medical University Zhijian Wei the First A liated Hospital of Anhui Medical University Zhangming Chen The Forth A liated Hospital of Anhui Medical University Peng Xu The Forth A liated Hospital of Anhui Medical University Gang Wang The Forth A liated Hospital of Anhui Medical University Hai Zhu The rst A liated Hospital of Anhui Medical University Wenxiu Han The rst A liated Hospital of Anhui Medical University Aman Xu (  18788831253@163.com ) First A liated Hospital of Anhui Medical University
Effect of Sales Promotion Management on Organizational Profitability a Comparative Study of Cadbury Nig Plc and Nestle Nig Plc

This paper critically examined the impact of sales promotion and marketing on organizational profitability, with a specific focus on Cadbury Nig Plc and Nestlé Nig Plc, Lagos-State. This study employed a descriptive survey design. A sample size of 100 respondents was selected using convenient sampling technique of which 100 respondents filled and returned the questionnaire. Data from the questionnaire were analyzed using special software for statistics which is called statistical package for social science (SPSS) version 20. The study found out that there was a significant relationship between sales promotion and organizational profitability. Also, there is a significant relationship between consumers commitment and repeat purchase and therefore recommends that much bonuses should be in place to aid consumers to repeat purchase. Such bonuses include buying one get one free, coupon rate ticket among others.
Explorer mir-181 A / B-1 controls thymic selection of treg cells and tunes their suppressive capacity

The interdependence of selective cues during development of regulatory T cells (Treg cells) in the thymus and their suppressive function remains incompletely understood. Here, we analyzed this interdependence by taking advantage of highly dynamic changes in expression of microRNA 181 family members miR-181a-1 and miR-181b-1 (miR-181a/b-1) during late T-cell development with very high levels of expression during thymocyte selection, followed by massive down-regulation in the periphery. Loss of miR-181a/b-1 resulted in inefficient de novo generation of Treg cells in the thymus but simultaneously permitted homeostatic expansion in the periphery in the absence of competition. Modulation of T-cell receptor (TCR) signal strength in vivo indicated that miR-181a/b-1 controlled Treg-cell formation via establishing adequate signaling thresholds. Unexpectedly, miR-181a/b-1–deficient Treg cells displayed elevated suppressive capacity in vivo, in line with elevated levels of cytotoxic T-lymphocyte–associated 4 (CTLA-4) protein, but not mRNA, in thymic and peripheral Treg cells. Therefore, we propose that intrathymic miR-181a/b-1 controls development of Treg cells and imposes a developmental legacy on their peripheral function. PLOS Biology | https://doi.org/10.1371/journal.pbio. 2006716 March 11, 2019 1 / 27 a1111111111 a1111111111 a1111111111 a1111111111 a1111111111
Tornando Fuzzy C-Means Escal· avel para Bancos de Dados Arbitrariamente Grandes

Domingos and Hulten developed a general framework to scale up ma- chine learning algorithms and applied to K-Means clustering. In this work, we adapt this method to scale up the Fuzzy C-Means (FCM) to arbitrarily large da- tasets. This adaptation is not straightforward because, as opposed to K-Means, the FCM learner's error is not a function of the number of examples owned by the clusters. Instead, each cluster is associated with every example through the membership matrix. In this way we developed the Very Fast Fuzzy C-Means (VFFCM), a clustering algorithm that uses a minimum number of examples (de- termined theoretically by Hoeffding bound) in each of its steps to guarantee that the resulting model does not differ signicantly from the one that would be created passing the entire data through the FCM.
Distribution of (1 → 4)- β -galactans, arabinogalactan proteins, xylans and (1 → 3)- β -glucans in tracheid cell walls of softwoods

Summary Polysaccharides were located in the walls of normal and compression wood tracheids of Pinus radiata (radiata pine), Picea sitchensis (Sitka spruce) and Picea abies (Norway spruce) by transmission electron microscopy using immunogold labelling with monoclonal antibodies to (1 → 4)- β -galactan (LM5), (1 → 3)- β -glucan, arabinogalactan proteins (AGPs) (MAC207) and heteroxylans (LM10 and LM11). In fully di ﬀ erentiated compression wood tracheids, (1 → 4)- β -galactan was found in the S2 (L) layer and, to a smaller extent, at the interface between the compound middle lamella and the S1 layer. (1 → 4)- β -Galactan appeared to be displaced from, or modi ﬁ ed in, the S1 layer during cell wall formation. (1 → 3)- β -Glucan (callose) was con ﬁ ned to the helical cavities in the inner S2 layer of severe compression wood. MAC207 AGP glycan epitope was found exclusively in the S1 and S3 layers of normal wood tracheids and in the S1 and inner S2 layers of compression wood tracheids. Binding of LM10, which speci ﬁ cally recognizes unsubstituted or low-substituted xylans, occurred at similar locations to the MAC207 epitope, whereas binding of LM11, which recognizes more highly substituted as well as unsubstituted xylans, occurred throughout the tracheid walls with the exception of the primary wall. Immunogold labelling showed that the di ﬀ erent wall layers of softwood tracheids have di ﬀ erent polysaccharide compositions which change abruptly during cell wall formation. tense LM5 labelling of young pine normal wood observed here compared with the older spruce sections is not species speci ﬁ c but caused by the age of the cambial cells from which the tracheids were formed. Young cambial age may well be associated with higher concentrations of RG I galac-tans in the primary walls. labelling, labelling, a polyclonal antibody against a peptide in the protein backbone of a tomato that the walls of xylem tracheary elements even after lignin deposition and Showalter 2000). is consistent with our results showing the persistence of AGP glycan epitopes after ligni ﬁ cation.
The spleen physiologically clears Aβ, and splenectomy aggravates Alzheimer-type pathogenesis

Zhong-Yuan Yu Third Military Medical University Daping Hospital and Research Institute of Surgery Dong-Wan Chen Third Military Medical University Daping Hospital and Research Institute of Surgery Cheng-Rong Tan Third Military Medical University Daping Hospital and Research Institute of Surgery Gui-Hua Zeng Third Military Medical University Daping Hospital and Research Institute of Surgery Chen-Yang He Third Military Medical University Daping Hospital and Research Institute of Surgery Xian-Le Bu Third Military Medical University Daping Hospital and Research Institute of Surgery Yan-Jiang Wang (  wayaja@163.com ) Daping hospital
Using Simulated Training Data of Voxel-Level Generative Models to Improve 3D Neuron Reconstruction

Reconstructing neuron morphologies from fluorescence microscope images plays a critical role in neuroscience studies. It relies on image segmentation to produce initial masks either for further processing or final results to represent neuronal morphologies. This has been a challenging step due to the variation and complexity of noisy intensity patterns in neuron images acquired from microscopes. Whereas progresses in deep learning have brought the goal of accurate segmentation much closer to reality, creating training data for producing powerful neural networks is often laborious. To overcome the difficulty of obtaining a vast number of annotated data, we propose a novel strategy of using two-stage generative models to simulate training data with voxel-level labels. Trained upon unlabeled data by optimizing a novel objective function of preserving predefined labels, the models are able to synthesize realistic 3D images with underlying voxel labels. We showed that these synthetic images could train segmentation networks to obtain even better performance than manually labeled data. To demonstrate an immediate impact of our work, we further showed that segmentation results produced by networks trained upon synthetic data could be used to improve existing neuron reconstruction methods.
Accelerating Psychological Science With Metastudies: A Demonstration Using the Risky-Choice Framing Effect

A metastudy is a set of many tiny studies (microstudies) created from a much larger collection of possibilities. Metastudies can yield many of the benefits of time-consuming replications and meta-analyses but more efficiently and with greater attention to generalizability and the causal effects of moderators. Statistical precision and power are higher than in studies with the same total sample size but with fewer conditions and more participants per condition. In this article, we describe metastudies and their benefits, demonstrate how to conduct a metastudy using the well-known risky-choice framing effect as an example, and report on the generalizability of that effect. In three metastudies (total N = 2,338), the framing effect generalized well across most of the potential moderators tested, as was expected. Surprisingly, however, the effect was up to twice as large when the certain option was replaced with a slightly risky option; prospect theory predicts the opposite, and fuzzy-trace theory predicts no difference. Metastudies provide a relatively quick and not-so-painful way of examining an effect’s generalizability without waiting for a meta-analysis. Both individual labs and multilab networks are encouraged to shift from traditional studies to metastudies.
Prebiotic effects of plant-derived (poly)phenols on host metabolism: Is there a role for short-chain fatty acids?

Abstract The gut microbiota has been extensively investigated during the last decade because of its effects on host neuroendocrine pathways and other processes. The imbalance between beneficial and pathogenic bacteria, known as dysbiosis, may be a determining predisposing factor for many noncommunicable chronic diseases, such as obesity, type 2 diabetes mellitus, metabolic syndrome, and Alzheimer’s disease. On the other hand, interventions aiming to reestablish the balance between microbiota components have been suggested as potential preventive therapeutic strategies against these disorders. Among these interventions, dietary supplementation with (poly)phenols has been highlighted due to the modulatory effects exerted by those compounds on the gut microbiota. In addition, (poly)phenol consumption is associated with increased production of short-chain fatty acids (SCFAs), a set of microbial metabolites whose actions are ascribed to improving the abovementioned metabolic disorders. Thus, this review discusses the modulation of the gut microbiota by prebiotic (poly)phenols based on in vivo studies performed with isolated (poly)phenolic compounds, their interaction with the gut microbiota and the production of SCFAs in pursuit of the molecular mechanisms underlying the health effects of (poly)phenols on host metabolism.
Current Recommendations for Perioperative Brain Health: A Scoping Review

Perioperative complications such as stroke, delirium, and neurocognitive dysfunction are common and responsible for increased morbidity and mortality. Our objective was to characterize and synthesize the contemporary guidelines on perioperative brain health for noncardiac, non-neurologic surgery in a scoping review. We performed a structured search for articles providing recommendations on brain health published between 2016 and 2021 and included the following complications: perioperative stroke and perioperative neurocognitive disorders, the latter of which encompasses postoperative delirium and a spectrum of postoperative cognitive dysfunction. We categorized recommendations by subtopic (stroke, postoperative delirium, postoperative cognitive dysfunction), type (disclosure/ethics/policies, prevention, risk stratification, screening/diagnosis, and management), and pharmacological versus nonpharmacological strategies. We noted country of origin, specialty of the authors, evidence grade (if available), and concordance/discordance between recommendations. Eight publications provided 129 recommendations, originating from the United States (n=5), Europe (n=1), United Kingdom (n=1), and China (n=1). Three publications (37%) applied grading of evidence as follows: Grading of Recommendations, Assessment, Development, and Evaluations (GRADE): A, 30%; B, 36%; C, 30%; D, 4%. We identified 42 instances of concordant recommendations (≥2 publications) on 15 themes, including risk factor identification, risk disclosure, baseline neurocognitive testing, nonpharmacological perioperative neurocognitive disorder prevention, intraoperative monitoring to prevent perioperative neurocognitive disorders, avoidance of benzodiazepines, delaying elective surgery after stroke, and emergency imaging and rapid restoration of cerebral perfusion after perioperative stroke. We identified 19 instances of discordant recommendations on 7 themes, including the use of regional anesthesia and monitoring for perioperative stroke prevention, pharmacological perioperative neurocognitive disorder management, and postoperative stroke screening. We synthesized recommendations for clinical practice and highlighted areas where high-quality evidence is required to inform best practices in perioperative brain health.
Targeting neutrophils in inflammatory bowel disease: revisiting the role of adsorptive granulocyte and monocyte apheresis

ABSTRACT Introduction Inflammatory bowel disease (IBD) is a chronic immune-mediated disease of the gastrointestinal tract comprising Crohn’s disease (CD) and ulcerative colitis (UC). While any part of the digestive tract can be affected in CD, mucosal inflammation in UC is limited to the colon. Differences and similarities between the two conditions are reflected by their pathophysiology. Areas covered An overview of immunological aspects, pharmacological management, and biomarkers of IBD is provided. The role of adsorptive granulocyte and monocyte apheresis (GMA) is reviewed including its primary and secondary effects on the immune system, as well as clinical studies in IBD (mainly UC), and potential biomarkers for adsorptive GMA. Expert opinion In UC, adsorptive GMA with Adacolumn (Adacolumn®, JIMRO Co., Ltd. Takasaki, Gunma, Japan) selectively depletes elevated myeloid lineage leukocytes and has a range of beneficial secondary immune effects. Adsorptive GMA is a safe and effective non-pharmacological treatment option for UC. Pilot studies have reported promising results for adsorptive GMA in combination with biological agents, although larger studies are required. Fecal calprotectin concentrations, neutrophil counts in histological samples and/or the neutrophil/lymphocyte ratio in peripheral blood may prove to be useful biomarkers for predicting GMA effectiveness in the future.