Miracle-dz/UniFAR-FTUs huggingface dataset:
Using Motor Imagery to Access Alternative Attentional Strategies When Navigating Environmental Boundaries to Prevent Freezing of Gait – A Perspective

Freezing of gait can cause reduced independence and quality of life for many with Parkinson’s disease. Episodes frequently occur at points of transition such as navigating a doorway. Therapeutic interventions, i.e., drugs and exercise, do not always successfully mitigate episodes. There are several different, but not exclusive causes for freezing of gait. People with freezing of gait are able to navigate dynamic situations like stairways by utilizing a different attentional strategy to over-ground walking, but may freeze when passing through a doorway. The question is, is it possible to employ a special attentional strategy to prevent freezing at this point? Motor imagery allows for learning motor skills in absolute safety and has been widely employed in a variety of populations, including other neuro-compromised groups. Motor imagery is not studied in a homologous manner in people with Parkinson’s Disease, leading to conflicting results, but may have the potential to establish a different attentional strategy which allows a subject to mitigate freezing of gait episodes. This paper will identify and discuss the questions that still need to be answered in order to consider this approach i.e., can this population access motor imagery, can motor imagery alter the attentional strategy employed when moving through doorways, what is the best motor imagery approach for people with Parkinson’s Disease and freezing of gait, and what dosage is most effective, while briefly outlining future research considerations.
Endoscopic Surveillance in Inflammatory Bowel Diseases: Selecting a Suitable Technology

In the treat-to-target era, endoscopy has become the backbone of the assessment of remission, defined as mucosal healing, in inflammatory bowel disease (IBD) patients. Current recommendations indicate that endoscopic procedures should be performed with high-definition white-light endoscopy (HD-WLE), as it guarantees the best possible visualization of the mucosa. With respect to endoscopic surveillance, the preventive strategy for dysplasia and colorectal cancer (CRC) in long-standing IBD, is the use of dye-chromoendoscopy (DCE), which enhances the mucosal pattern of the colonic walls. DCE has been established as the gold standard for dysplasia detection and is at present incorporated in all international guidelines. Over the past years, novel technologies, such as high-definition endoscopic imaging, and optical and digital enhancement tools have revolutionized the quality and level of fine details of vascular and mucosal patterns. These endoscopic images have the ambition to reflect histological changes for suspected neoplastic lesions and inflammation or healing and are emerging as potential alternatives to DCE. Indeed, the comparison of DCE with high-definition imaging is an open issue that deserves further investigation. We aimed to examine and summarize the technical aspects and the current evidence on endoscopic technologies with a specific focus on the surveillance in IBD patients.
Methodological Comparison of the Production Approach 2013 and 2019 for Quantifying the Carbon Stock in Harvested Wood Products in China

Harvested wood products (HWP) play an important role in global climate change mitigation. The Production Approach, an internationally accepted HWP carbon accounting approach by the Intergovernmental Panel on Climate Change (IPCC), has been revised several times to enhance the accuracy of the accounting results. This study compared the methodological differences in the Production Approach elaborated in the 2013 Revised Supplementary Methods and Good Practice Guidance Arising from the Kyoto Protocol (PA2013) and 2019 Refinement to the 2006 IPCC Guidelines for National Greenhouse Gas Inventories (PA2019). We used PA2019 to calculate the HWP carbon stock in China under different wood utilization scenarios. In terms of recycling and reusing of recovered paper, we found that PA2019 has a more accurate representation of the increasing proportion of paper and paperboard materials produced using recovered paper in the world. In 2019, the HWP carbon stock in China was 815.94 Mt (1 Mt = 106 t) using PA2019. In detail, the carbon stock of sawnwood, wood-based panels, and paper and paperboard were 208.52 Mt, 559.73 Mt, and 47.69 Mt, respectively. Scenario simulation results show that half-life was an important factor that affecting HWP carbon stock. China can improve HWP carbon stock by increasing the recovered paper utilization rate for paper products or increasing the utilization rate of HWP with long half-life in construction (structural material). The additional carbon stock obtained by changing the utilization structure of wood and improve the half-life of HWP will not be large until decades later but nonetheless important.
Cortical Short-Range Fiber Connectivity and Its Association With Deep Brain White Matter Hyperintensities in Older Diabetic People With Low Serum Vitamin B12

Although previous studies have indicated that older people with diabetes mellitus (DM) had an approximately two times larger white matter hyperintensity (WMH) load than those without DM, the influence of WMHs on cognition is uncertain and inconsistent in the literature. It is unclear whether the short-range fibers in the juxtacortical region, traditionally considered to be spared from WMH pathology, are enhanced as an adaptive response to deep WM degeneration in older diabetic people with normal cognition. Moreover, the specific effect of vitamin B12 deficiency, commonly accompanied by DM, remains to be investigated. This study implemented a specialized analysis of the superficial cortical short-range fiber connectivity density (SFiCD) based on a data-driven framework in 70 older individuals with DM and low serum vitamin B12. Moreover, the effects of time and vitamin B12 supplementation were assessed based on a randomized placebo-controlled trial in 59 individuals. The results demonstrated a higher SFiCD in diabetic individuals with a higher deep WMH load. Additionally, a significant interaction between DWMH load and homocysteine on SFiCD was found. During the 27-month follow-up period, a longitudinal increase in the SFiCD was observed in the bilateral frontal cortices. However, the observed longitudinal SFiCD change was not dependent on vitamin B12 supplementation; thus, the specific reason for the longitudinal cortical short fiber densification may need further study. Overall, these findings may help us better understand the neurobiology of brain plasticity in older patients with DM, as well as the interplay among DM, WMH, and vitamin B12 deficiency.
Treatment-Resistant Depression in Portugal: Perspective From Psychiatry Experts

Guidance about treatment-resistant depression (TRD) in Portugal is very limited, even though depression prevalence is among the highest in European countries. A questionnaire was conducted, followed by two advisory boards with seven Portuguese psychiatry experts, to characterize and discuss MDD and TRD epidemiology, diagnosis, patient journey, treatment options, and unmet clinical needs. Consensus was reached on the main issues. In daily practice, TRD can be defined as moderate to severe MDD episodes with insufficient clinical improvement after two antidepressant treatments, taken in adequate doses and duration. TRD diagnosis and treatment are mostly decided by psychiatrists at public hospitals. Treatment type and duration must be adjusted to characteristics of the patient and the depressive episode, including symptoms, number of previous episodes, comorbidities, and previous treatment response and side effects. The most relevant objectives of TRD treatment are reaching response and remission, prevention of suicide, and improvement of quality of life, functionality, and wellbeing. Regarding pharmacotherapy, antidepressant switch occurs more frequently with non-response, while optimization, combination, and augmentation are considered for patients with partial response. Psychotherapy should be considered in parallel to pharmacological treatment. Brain stimulation techniques are underused. Lifelong treatment is required for recurrent or more chronic TRD episodes, but patient adherence is also poorer in these cases. In Portugal, TRD management is limited by lack of access to specialist care and to many treatment options. These aspects highlight that conventional pharmacotherapy does not lead to remission in many patients and that optimization strategies are frequently necessary to achieve satisfactory treatment outcomes.
A Genetic Resource for Rice Improvement: Introgression Library of Agronomic Traits for All AA Genome Oryza Species

Rice improvement depends on the availability of genetic variation, and AA genome Oryza species are the natural reservoir of favorable alleles that are useful for rice breeding. To systematically evaluate and utilize potentially valuable traits of new QTLs or genes for the Asian cultivated rice improvement from all AA genome Oryza species, 6,372 agronomic trait introgression lines (ILs) from BC2 to BC6 were screened and raised based on the variations in agronomic traits by crossing 170 accessions of 7 AA genome species and 160 upland rice accessions of O. sativa as the donor parents, with three elite cultivars of O. sativa, Dianjingyou 1 (a japonica variety), Yundao 1 (a japonica variety), and RD23 (an indica variety) as the recurrent parents, respectively. The agronomic traits, such as spreading panicle, erect panicle, dense panicle, lax panicle, awn, prostrate growth, plant height, pericarp color, kernel color, glabrous hull, grain size, 1,000-grain weight, drought resistance and aerobic adaption, and blast resistance, were derived from more than one species. Further, 1,401 agronomic trait ILs in the Dianjingyou 1 background were genotyped using 168 SSR markers distributed on the whole genome. A total of twenty-two novel allelic variations were identified to be highly related to the traits of grain length (GL) and grain width (GW), respectively. In addition, allelic variations for the same locus were detected from the different donor species, which suggest that these QTLs or genes were conserved and the different haplotypes of a QTL (gene) were valuable resources for broadening the genetic basis in Asian cultivated rice. Thus, this agronomic trait introgression library from multiple species and accessions provided a powerful resource for future rice improvement and genetic dissection of agronomic traits.
Can Maintaining Optimal Magnesium Balance Reduce the Disease Severity of COVID-19 Patients?

The coronavirus disease (COVID-19) caught the world by surprise, claiming millions of lives due to its deadly effects. Ongoing research studies evaluate the measures that can reduce the severity of symptoms in patients infected by the severe acute respiratory syndrome coronavirus 2 (SARS−CoV−2). Magnesium is an essential nutrient that has many studied benefits in humans. This brief commentary aims to describe the potential benefits of magnesium on COVID-19 patients and the reported effects of low versus high magnesium levels in SARS−CoV−2 infected individuals. Also, the potential benefits of vitamin D and how magnesium acts as a cofactor to activate vitamin D functions are elaborated. The results of the existing studies point towards evidence that magnesium may have significant benefits in reducing the severity of COVID-19 symptoms. There is also evidence that magnesium-dependent vitamin D activities may have antiviral effects, thus potentially being able to reduce rates of COVID-19 infection, which is a hypothesis that should be further tested. The COVID-19 primarily causes respiratory distress but has a broad range of other clinical manifestations and affects various organs and systems in the body. COVID-19 is especially lethal to elderly populations at higher risk (1, 2). As of September 3rd, 2021, the current worldwide death rate of individuals infected by COVID-19 is 4,539,723 (World Health Organization). Many public health measures have already been taken to try to prevent the spread of COVID-19, such as face mask mandates, vaccine inoculation, quarantine, social distancing, limited capacities at public venues, and a shift to online work. However, COVID-19 is still proving to be a health concern as cases of infection continue to rise. The continued infection of individuals by COVID-19 may be due to the high transmissibility of the virus (3–6). It is also proposed that some of the new variants of the virus are even more rapidly transmissible and lethal. Thus, certain preventative measures are essential to find to reduce the severity of symptoms and improve patient outcomes in individuals that have been infected, since the prevention of infection is not always possible. Basic nutrients that optimize physiologic functions in the body, such as magnesium,may be used as a prophylactic measure that can improve patient outcomes in individuals infected by SARS−CoV−2, and potentially even reduce the intensity of the infection by the virus by potentiating vitamin D functions. In the U.S., more than 50% of people are magnesium deficient (7, 8), and magnesium deficiency is also prevalent in many other countries. The low level of magnesium in the general population may make individuals more vulnerable to viral insults. The high prevalence of magnesium deficiency makes it important to determine how optimal and suboptimal magnesium levels affect COVID-19 patient outcomes, which this paper aims to elaborate on.
Temperature Affects Antagonism Among Coral-Associated Bacteria

Reef-building corals are invertebrate animals that associate with diverse microorganisms, including Symbiodiniaceae, bacteria, fungi, and archaea. This symbiotic consortium, called the holobiont, is a dynamic system and rapidly responds to environmental temperatures. At present, the effects of temperature on bacteria-bacteria interactions in the coral-associated bacterial community are not clear. Antagonism is considered one of the potential structuring forces in coral microbial communities. Here, we examined the antagonistic interactions among 32 coral-associated bacteria and the physiological and biochemical characteristics of these isolates at different temperatures. The results showed that the antagonism breadth (i.e. the total number of antagonistic interactions) increased but antagonism intensity (i.e. the size of the inhibition zone) decreased at 32°C. The antagonistic interaction network was nested and sender-determined both at 25°C and 32°C, suggesting that the competition networks of coral-associated bacteria were more influenced by the antagonist strains than sensitive strains. Furthermore, we found that the elevated temperature increased the complexity of the antagonistic network. By evaluating the correlations between antagonism and the phylogenetic and phenotypic distances, we demonstrated that the antagonism probability correlated with the phylogenetic distance rather than phenotypic distance. Moreover, the antagonist strains have a wider metabolic niche space, i.e., grew on more carbon sources, than the antagonized strains at 25°C, while there was no difference at 32°C, suggesting the trade-off between antagonism and resource exploitation shifted in the antagonistic interactions under the higher temperature. These findings will be helpful for understanding the bacterial interactions in coral holobionts and the assembly of bacterial community in altered environments, especially under heat stress.
Is the Energy Cost of Rowing a Determinant Factor of Performance in Elite Oarsmen?

In elite oarsmen, the rowing ergometer is a valuable tool for both training and studying rowing performance determinants. However, the energy cost of rowing, often reported as a determinant of performance, has never been described for ergometer rowing. Therefore, this study aimed to characterize the energy cost of ergometer rowing (ECR) in elite oarsmen, its contribution to 2,000 m performance, and its determinants. This study was conducted on 21 elite oarsmen from the French national team. It included an incremental exercise test up to exhaustion and an all-out performance test over 2,000 m, both conducted on a rowing ergometer. Gas exchange analysis was performed to calculate oxygen uptake and substrate utilization rate. Whole blood lactate concentrations during the incremental test were obtained from the earlobe. During the incremental test, ECR displayed a significant linear increase up to a plateau that reached a mean rowing speed of 5.23 ± 0.02 m⋅s–1. The ECR values at 300, 350, and 400 W were positively correlated with performance expressed as the time required to perform the 2,000 m distance on the rowing ergometer. The same ECR values were found to be significantly related to fat oxidation (expressed in percentage of total energy supply) and blood lactate concentrations. This study provides the first description of ECR and of its relationship to exercise intensity on the rowing ergometer in elite oarsmen. ECR appeared to be a factor of performance and interestingly was related to energy supply from fat and blood lactate concentrations.
Why the Mixed Layer Depth Matters When Diagnosing Marine Heatwave Drivers Using a Heat Budget Approach

Marine heatwaves (MHWs) are extreme warming events that can result in significant damage to marine ecosystems and local economies. The primary drivers of these events have been frequently studied using an upper ocean heat budget. However, various surface mixed layer (SML) depths have been used with little attention paid to the impact of the depth chosen on heat budget term estimates. We analyse MHW drivers in two dynamically contrasting regions off the east coast of Australia (East Australian Current extension) and the west coast of New Zealand over a 30-year period (1985–2014, inclusive). We compare the magnitude of the air-sea heatflux and advection terms in a volume-averaged heat budget using three different SML depth estimates. We show that the SML depth over which the heat budget is calculated has direct consequences on the identification of MHW dominant drivers. The air-sea heatflux term is amplified when the SML depth is underestimated and dampened when overestimated. The variation in the magnitude of the advection term is dependent on the barotropic or baroclinic structure of the currents. We, also, show that the impact on MHW driver classification is both temporally and regionally dependent. Generally, a deep SML estimate results in more MHWs being classified as advection and less classified as air-sea heatflux-driven. However, during the cool months, a shallow estimate produces the opposite pattern and to a varying degree of intensity depending on the region's dynamics. Use of daily and spatially variable SML depth in a heat budget calculation allows the comparison between regions with different dynamics influencing the mixed layer depth. These results show that when using a heat budget approach to explore marine heatwaves over extended time and space (e.g., regions and seasons), it is imperative to consider the temporal and spatial variability in the SML depth.
The eEgg: Evaluation of a New Device to Measure Pain

Aim: The aim of this study was to evaluate whether pain stimuli can be measured validly and reliably by the eEgg (electronic Egg), a new device to measure pain intensity, in comparison to the hand dynamometer. Methods: This study consists of screening and diagnostic tests conforming to the standard criterion of handgrip strength measurement. Fifty healthy participants (25 women, 25 men; age, 39.1 ± 13.7 years) participated in this study. The approach of intermodal comparison was used to transfer different degrees of pain sensations into measurable handgrip strength values. This included an intensity comparison of 10-100% of the subjective maximum handgrip strength and an application of thermal stimuli of 34-48°C. The eEgg was compared to the numeric rating scale (NRS) as a categorization method regarding the subjective assessment of pain. An online questionnaire was distributed to test the evaluation of the product’s features. Results: Regarding the experiment’s validity, the handgrip strength values showed significant (p < 0.05) positive correlations between the eEgg and the hand dynamometer (intensities: r=0.328 to r=0.550; thermal stimuli: r=0.353 to r=0.614). The reliability results showed good to very good correlations (p < 0.05) in the calculated ICC (intraclass correlation coefficient) values between the individual measurement devices: eEgg intensities: ICC=0.621 to 0.851; thermal stimuli: ICC=0.487 to 0.776 and hand dynamometer intensities: ICC= 0.789 to 0.974; thermal stimuli: ICC=0.716 to 0.910. Conclusion: The new eEgg device shows strong correlations with the hand dynamometer. The central limitation focuses on the obligatory use of an arbitrary unit (AU) for the eEgg. The results of the study indicate that this device can be used in medical and therapeutic practice in the future.
Safety of Health Care Workers in a War Zone—A European Issue

According to the International Law and Rule 25, “Medical personnel exclusively assigned to medical duties must be respected and protected in all circumstances. They lose their protection if they commit, outside their humanitarian function, acts harmful to the enemy. ” (1, 2). Despite this law, it is not uncommon that this aspect of international law is violated during conflicts. The International Committee of the Red Cross (ICRC) has emphasized that the problem of not protecting health care workers in a war zone is one of the most crucial yet overlooked humanitarian issues today (3), and conflict andwar situations increase risk to harm of suchworkers (4, 5). Furthermore, the deleterious effects of war zone operations on health workers extends tomaterial and supply shortages including breakdown in the supply of services (e.g., electricity, medicines, and equipment) which further increases stress on health care personnel (6). In the current conflict in Ukraine, the International Council of Nurses (ICN) has highlighted in a press release that the safety of health care workers during this conflict is paramount (7). This plea has been sent to both to both Ukrainian and Russian respective associations.