Genetically Engineered Biomaterials Advancement in Genetic Engineering Improved survival with DOF regimen for the treatment of metastatic gastric adenocarcinoma – A single-center experience

The involvement of genetic engineering techniques in the development of novel biomaterials has a huge impact on a vast range of applications. The capability of new genetically engineered material has achieved various innovative scopes in the biomedical industry. Such materials are usually designed via chemical and physical methods of genetic engineering. According to the genetic basis of sequence, molecular weight, folded structure, and stereochemistry, protein polymers thus suggest a generous view for the architecture of protein-based genetically engineered biomaterials. The scopes of developing genetically engineered biomaterials are leading to improve biological features of materials which can enhance the applicability and properties of materials. In the last five years, Genetic engineering research is becoming closer to the mass consumer. Leading global geneticists predict that in the coming years, a boom will occur in the genetic engineering market, comparable to the massive spread of personal computers in the 1980s. Thus genetically modified biomaterials with upgraded biological properties, expanding towards mass-scale industrial production, and the considerable consumption in regular universal activities. The techniques used to develop new materials and to modify the properties of existing materials, are subjected to different industries and fields of scientific researches. CRISPR is an authoritative research tool that facilitates scientists to deal with the expression of a gene. It has shown tremendous potential in genome research due to its ability to delete unwanted traits, and possibly even replace them with desirable traits. It is agile, worthwhile, and more authentic than any preceding gene-editing techniques. Genetically engineered biomaterials have been an enormous field of research over the last fifteen years and CRISPR has already initiated performing a significant aspect in boosting biomaterial research. Abstract BACKGROUND: Patients with metastatic gastric adenocarcinoma have a relatively poor prognosis with a median survival of 6 months. The three-drug regimen of docetaxel, oxaliplatin and fluorouracil (DOF) has been shown to improve survival compared to the two-drug regimen of docetaxel and oxaliplatin with similar toxicity. However, there is no published Indian experience with this regimen. AIM: The aim of this study was to evaluate the efficacy of DOF regimen in Indian patients. MATERIAL AND METHODS:All patients with metastatic gastric cancer who were treated with DOF regimen at our tertiary care centre in North India from 2014 to 2018 were retrospectively reviewed. 15 patients received DOF regimen as docetaxel 60 mg/m2 and oxaliplatin 85 mg/m2 on Day 1, and continuous infusion 5-FU 750 mg/m2 over 48 hours with pegylated-granulocyte colony-stimulating factor support every 2 weeks until progression or unacceptable toxicity. The endpoints were overall response rate (ORR), progression-free survival (PFS) and overall survival (OS) which were evaluated using Kaplan-Meier analysis. RESULTS: Fifteen patients with a median age of 52 years were identified; 73% were males. Overall response rate was seen in 87% patients (complete response: 20%, partial response: 60%, stable disease: 7%) and progressive disease in 13%. With a median follow-up of 14 months, the median PFS was seven months and the median OS was 16 months from the start of therapy. 1-year PFS was 22%, and 1-and 2-year survival was 79% and 26%, respectively. CONCLUSION: DOF regimen is an effective and feasible regimen in patients with metastatic gastric cancer and shows similar survival to historical regimens. ABSTRACT The involvement of genetic engineering techniques in the development of novel biomaterials has a huge impact on a vast range of applications. The capability of new genetically engineered material has achieved various innovative scopes in the biomedical industry. Such materials are usually designed via chemical and physical methods of genetic engineering. According to the genetic basis of sequence, molecular weight, folded structure, and stereochemistry, protein polymers thus suggest a generous view for the architecture of protein-based genetically engineered biomaterials. The scopes of developing genetically engineered biomaterials are leading to improve biological features of materials which can enhance the applicability and properties of materials. In the last five years, Genetic engineering research is becoming closer to the mass consumer. Leading global geneticists predict that in the coming years, a boom will occur in the genetic engineering market, comparable to the massive spread of personal computers in the 1980s. Thus genetically modified biomaterials with upgraded biological properties, expanding towards mass-scale industrial production, and the considerable consumption in regular universal activities. The techniques used to develop new materials and to modify the properties of existing materials, are subjected to different industries and fields of scientific researches. CRISPR is an authoritative research tool that facilitates scientists to deal with the expression of a gene. It has shown tremendous potential in genome research due to its ability to delete unwanted traits, and possibly even replace them with desirable traits. It is agile, worthwhile, and more authentic than any preceding gene-editing techniques. Genetically engineered biomaterials have been an enormous field of research over the last fifteen years and CRISPR has already initiated performing a significant aspect in boosting biomaterial research. ABSTRACT The involvement of genetic engineering techniques in the development of novel biomaterials has a huge impact on a vast range of applications. The capability of new genetically engineered material has achieved various innovative scopes in the biomedical industry. Such materials are usually designed via chemical and physical methods of genetic engineering. According to the genetic basis of sequence, molecular weight, folded structure, and stereochemistry, protein polymers thus suggest a generous view for the architecture of protein-based genetically engineered biomaterials. The scopes of developing genetically engineered biomaterials are leading to improve biological features of materials which can enhance the applicability and properties of materials. In the last five years, Genetic engineering research is becoming closer to the mass consumer. Leading global geneticists predict that in the coming years, a boom will occur in the genetic engineering market, comparable to the massive spread of personal computers in the 1980s. Thus genetically modified biomaterials with upgraded biological properties, expanding towards mass-scale industrial production, and the considerable consumption in regular universal activities. The techniques used to develop new materials and to modify the properties of existing materials, are subjected to different industries and fields of scientific researches. CRISPR is an authoritative research tool that facilitates scientists to deal with the expression of a gene. It has shown tremendous potential in genome research due to its ability to delete unwanted traits, and possibly even replace them with desirable traits. It is agile, worthwhile, and more authentic than any preceding gene-editing techniques. Genetically engineered biomaterials have been an enormous field of research over the last fifteen years and CRISPR has already initiated performing a significant aspect in boosting biomaterial research. ABSTRACT The involvement of genetic engineering techniques in the development of novel biomaterials has a huge impact on a vast range of applications. The capability of new genetically engineered material has achieved various innovative scopes in the biomedical industry. Such materials are usually designed via chemical and physical methods of genetic engineering. According to the genetic basis of sequence, molecular weight, folded structure, and stereochemistry, protein polymers thus suggest a generous view for the architecture of protein-based genetically engineered biomaterials. The scopes of developing genetically engineered biomaterials are leading to improve biological features of materials which can enhance the applicability and properties of materials. In the last five years, Genetic engineering research is becoming closer to the mass consumer. Leading global geneticists predict that in the coming years, a boom will occur in the genetic engineering market, comparable to the massive spread of personal computers in the 1980s. Thus genetically modified biomaterials with upgraded biological properties, expanding towards mass-scale industrial production, and the considerable consumption in regular universal activities. The techniques used to develop new materials and to modify the properties of existing materials, are subjected to different industries and fields of scientific researches. CRISPR is an authoritative research tool that facilitates scientists to deal with the expression of a gene. It has shown tremendous potential in genome research due to its ability to delete unwanted traits, and possibly even replace them with desirable traits. It is agile, worthwhile, and more authentic than any preceding gene-editing techniques. Genetically engineered biomaterials have been an enormous field of research over the last fifteen years and CRISPR has already initiated performing a significant aspect in boosting biomaterial research. ABSTRACT The involvement of genetic engineering techniques in the development of novel biomaterials has a huge impact on a vast range of applications. The capability of new genetically engineered material has achieved various innovative scopes in the biomedical industry. Such materials are usually designed via chemical and physical methods of genetic engineering. According to the genetic basis of sequence, molecular weight, folded structure, and ster