Miracle-dz/UniFAR-FTUs huggingface dataset:
STUDY TO DETERMINE THE PRESENCE OF IRON DEFICIENCY ANEMIA AND BETA THALASSEMIA TRAIT SIMULTANEOUSLY

: Introduction: The feature of beta-thalassemia (β-TT) is common in this subcontinent as well as in Pakistan. 3% of our total population has been documented to have β-TT. Iron deficiency anemia (IDA) remains one of the most serious and important eating disorders in the world, especially in Pakistan. Microcytic hypochromic blood pictures are a common symptom of both disorders. The purpose of this study was to see if the two could coexist. Methods: This was a cross-sectional study conducted at the Department of Internal Medicine of Mayo Hospital Lahore for one-year duration from July 2019 to July 2020. A total of 54 participants were selected from the Medicine department. All of them had β-TT confirmed by capillary hemoglobin electrophoresis. Appropriate advice was given and informed consent was given. Relevant history was collected and a study was conducted. 5 ml of venous blood was collected and sent to the Biochemistry department to measure iron, ferritin, and serum iron binding capacity (TIBC). The transferrin saturation (T.Sat) was calculated from the formula (iron / TIBC) X100. Results: Finally, 54 patients who met the recruitment criteria were analyzed. Among them, 85% (46) of patients were women and 15% (8) were men. The median age was 30 years (range 11-80 years). Most of the 78% (42) patients belong to the 15 to 44 age group. Mean (± SD) HbA2 (%) was 5.35 (± 1.39), Hb (%) 9.04 ± (1.39), MCV (fl) - 67.02 (± 10.39), MCH (pg) - 21.06 (± 3.99), WFD (%) - 17.77 (± 3.85). Among them, 44.4% (24) had low iron levels (<40 μg / dl), 29.6% (16) had low ferritin (15 μgm / l), 33.3% (18) had high TIBC (> 407 μg / dl), and 50% (27) had low transferrin saturation (<16%). Iron deficiency was found in 13% (7) of patients across all parameters, and 63% (34) of patients were iron deficient in at least one parameter. Conclusions: In this study, the frequent occurrence of iron deficiency (29.6%) in people with β-TT, which is a potentially correctable clinical condition, was demonstrated. Iron levels among β-TT should be properly assessed, and people with iron deficiency should be treated promptly, which may improve their overall well-being.
A Compact, Optically red galaxy.

We report a new compact galaxy, SDSS J122958.84 + 138.0 (SDSS J1229 + 0001), which has unique morphological and stellar population properties that are rare in observations of the nearby Universe. SDSS J1229 + 0001 has an r -band absolute magnitude ( M r ) and half-light radius ( R h ) of − 17.75 mag and 520 pc, respectively. Located in a fairly low-density environment, morphologically it is akin to a typical early-type galaxy as it has a smooth appearance and red colour. However, interestingly, it possesses centrally concentrated star-forming activity with a signiﬁcant amount of dust. We present an analysis of its structural and stellar population properties using archival images and VLT/FORS2 spectroscopy. An analysis of the UKIDSS H -band image shows that the observed light distribution is better ﬁtted with a two-component S´ersic function with inner and outer component effective radii of 190 and 330 pc, respectively. The overall half-light radius measured in the H band is much smaller compared to optical, i.e. 290 pc. We prepared a spectral energy distribution from optical to far-infrared and interpret it to derive the star-formation rate, dust mass and stellar mass. We ﬁnd that SDSS J1229 + 0001 has dust mass M dust = 5.1 × 10 5 M (cid:2) with a dust-to-stellar mass ratio log( M dust /M ∗ ) = − 3 . 5. While the observed stellar population properties are – to some extent – like those of a typical S0 galaxy, a uniﬁed view from stellar population and structural properties may suggest that SDSS J1229 + 0001 is a smoking gun example of a compact early-type galaxy in formation.
THE POSITIVE ASSETS TO REVIEW THE IMPROVEMENT AND ITS NEURONAL FOCUS WERE LARGELY MAINTAINED BY RODENTS

: The positive assets to review the improvement and its neuronal focus were largely maintained by rodents. For example, a fundamental change in a living being's current circumstances can invigorate undeniable motivation (whether or not equally divided), promote new origins of hippocampal recognition and neuroplasticity, and further promote hippocampal deficiencies caused by neurodegenerative deficiencies. The bosses are concerned about whether these activities that improve thinking (or simplicity) will help to look like effects on people. Our current research was led from Lahore General Hospital Lahore from May 2018 to September 2019. Regardless of how the characteristic "driving characteristics" of standard life differ here, the specialists consistently adapt to new practices and conditions within their own unique domain of typical operation. At the moment, analysts speculate that the evaluation of colossal and, as far as anyone knows, invigorating virtual situations in PC games is the human partner of natural improvement. Specialists show that video players who clearly support multi-faceted 3D PC games perform better in the annoying memory task of candidates' propensity to see phenomenally comparative attractants from repeating substances. After a 3-week preparation period for the 3D computer game Super Mario 3D World, the recognition of video players showed improved taste restriction and motion sequences in the imitated work in the water maze. 2 control conditions, no such updates proven. Likewise, the tactful introduction to the joint hippocampal-related demonstration identified with the introduction to Super Mario before they were angry birds for a long time shows that the way humans found virtual conditions can affect the execution of the hippocampus.
SoftHand Pro: a Robust and Adaptive Bionic Hand to Enable Physical Interaction

—The loss of an upper limb is a major trauma which affects both the personal and the social dimensions of an individual, only solutions capable to properly balance functional an structural anthropomorphism can really restore the quality of life of people with limb loss. Nowadays, state of the art of prosthetic hands is divided between very simple hook-like systems, and more advanced solutions, that try to match the functions of human hand at the cost of sever lack in intuitiveness and reliability. In this talk we present the last evolution of the SoftHand Pro, a soft multi-digit prosthetic hand in which structural and functional anthropomorphism are obtained thanks to the fruitful combination of soft robotics technologies and sensory-motor synergies. We introduce the new design and discuss outcomes coming from its use in the context of the Cybathlon Experience 2018, highlighting how a soft and adaptive design help the user in the execution of the proposed daily life activites.
Simian Virus 40 Large T Antigen Can Speciﬁcally Unwind the Central Palindrome at the Origin of DNA Replication (cid:1)

The hydrophilic channels between helicase domains of simian virus 40 (SV40) large T antigen play a critical role in DNA replication. Previous mutagenesis of residues in the channels identiﬁed one class of mutants (class A: D429A, N449S, and N515S) with normal DNA binding and ATPase and helicase activities but with a severely reduced ability to unwind origin DNA and to support SV40 DNA replication in vitro. Here, we further studied these mutants to gain insights into how T antigen unwinds the origin. We found that the mutants were compromised in melting the imperfect palindrome (EP) but normal in untwisting the AT-rich track. However, the mutants’ defect in EP melting was not the major reason they failed to unwind the origin because supplying an EP region as a mismatched bubble, or deleting the EP region altogether, did not rescue their unwinding deﬁciency. These results suggested that speciﬁc separation of the central palindrome of the origin (site II) is an essential step in unwinding origin DNA by T antigen. In support of this, wild-type T antigen was able to speciﬁcally unwind a 31-bp DNA containing only site II in an ATPase-dependent reaction, whereas D429A and N515S failed to do so. By performing a systematic mutagenesis of 31-bp site II DNA, we identiﬁed discrete regions in each pentanucleotide necessary for normal origin unwinding. These data indicate that T antigen has a mechanism to speciﬁcally unwind the central palindrome.
Cardiac Population Image Quantiﬁcation: Analysis of 20K Subjects in the UK Biobank

The analysis of large-scale population imaging datasets has the potential to improve healthcare by discovering and understanding patterns and trends of disease that translate into pre-emptive care, and improved disease management. To date, few truly large cardiac imaging studies have been available to the research community, and none with the quality and expert annotations provided by the UK Biobank (UKB) cardiac imaging project. With studies of this magnitude ( > 100 , 000 subjects) a paradigm shift in the approach to image quantiﬁcation is required. Before truly large datasets, single module segmentation pipelines were suﬃcient to analyse rather small cohorts. However, with access to large biobanks, high-throughput, quality-aware fully-automatic parsing pipelines are essential for any reliable results to be expected. In this paper we present such a pipeline, and use the UKB as case study to show its potential. The proposed pipeline performs end-to-end image processing from raw image to morphological and functional quantiﬁcation while controlling input image, and output segmentation quality; all without user interaction. To the best of our knowledge, this is the ﬁrst paper tackling the fully automatic 3D statistical analysis of cardiovascular shape from cardiac MR images of the UKB population study, and providing global and regional reference ranges for all key cardiovascular functional indexes, from both left and right ventricles of the heart. We validate our workﬂow on a reference cohort of 4620 subjects for which manual delineations, and reference functional indexes exist. Our results show signiﬁcant agreement between the manually obtained reference indexes, and those automatically computed using our framework. In addition, we report the ﬁrst analysis on the largest cohort of cardiac MR images 20K subjects each comprised of 50 timepoints, i
BRCA1 and TP53 mutations in ovarian cancer: Molecular genetic insights and updated situations in Thailand

Ovarian cancer is the second most common gynecologic cancer among Thai women. It is the most lethal gynecologic cancer worldwide. The incident rate increases in women over 45 years old. Several genetic factors linked to ovarian cancer have been identified. Previous reports have shown that women with deleterious mutations in the BRCA1 gene had a high risk of developing ovarian tumors during their lifetime. TP53 mutation is also recognized as one of genetic factors associated with ovarian cancer. Around 50% of ovarian cancer patients contain various mutations in the TP53 gene resulting in the overexpression of the mutated proteins. Additionally, mutations of BRCA1 together with TP53 are found in the most aggressive subtype high-grade serous ovarian cancer (HGSOC). The prevalence of BRCA1 and TP53 mutations in breast and ovarian cancers has been reported in many populations. However, the mutation types seem to be different depending on ethnicity. In Thailand, the significance of both BRCA1 and TP53 gene mutations on ovarian cancer initiation and progression has not been completely elucidated. This review points out the incidence and association between BRCA1 as well as TP53 mutations and ovarian cancer. Cumulative data obtained from Thai population are shown. The knowledge may help improve genetic screening, prognosis and treatment selection for ovarian cancers in our country in the near future.
Formation of Intermediate Transcription Initiation Complexes at p ﬂiD and p ﬂgM by (cid:2) 28 RNA Polymerase

The (cid:1) subunit of prokaryotic RNA polymerase is an important factor in the control of transcription initiation. Primary (cid:1) factors are essential for growth, while alternative (cid:1) factors are activated in response to various stimuli. Expression of class 3 genes during ﬂagellum biosynthesis in Salmonella enterica serovar Typhimurium is dependent on the alternative (cid:1) factor (cid:1) 28 . Previously, a novel mechanism of transcription initiation at the ﬂiC promoter by (cid:1) 28 holoenzyme was proposed. Here, we have characterized the mechanism of transcription initiation by a holoenzyme carrying (cid:1) 28 at the ﬂiD and ﬂgM promoters to determine if the mechanism of initiation observed at p ﬂiC is a general phenomenon for all (cid:1) 28 -dependent promoters. Tem-perature-dependent footprinting demonstrated that promoter binding properties and low-temperature open complex formation are similar for p ﬂiC , p ﬂiD , and p ﬂgM . However, certain aspects of DNA strand separation and complex stability are promoter dependent. Open complexes form in a concerted manner at p ﬂgM , while a sequential pattern of open complex formation occurs at p ﬂiD . Open and initiated complexes formed by holoenzyme carrying (cid:1) 28 are generally unstable to heparin challenge, with the exception of initiated complexes at p ﬂgM , which are stable in the presence of nucleoside triphosphates. The (cid:2) subunit of bacterial RNA polymerase (RNAP) is an
Investigation of Inadequate Multiple Account Users in a Q&A Site by Considering Deviations of Answer Submission Order

(cid:151)Some users in a question and answer (Q&A) site use multiple user accounts and attempt to manipulate communications in the site. In order to detect these inadequate multiple account users precisely, it is important to investigate them from various points of view. In this paper, we investigate suspicious users from the viewpoint of deviations of answer submission order and discuss the reasons why and how the deviations occurred. The results of this study will give us a chance to investigate purposes and behaviors of inadequate multiple account users in a Q&A site.
Effect of Ascorbic Acid, Acetylsalicylic Acid, Sodium Bicarbonate, and Potassium Chloride Supplementation in Water on the Performance of Broiler Chickens Exposed to Heat Stress 1

SUMMARY This study investigated the effects of continuous supplementation of ascorbic acid (62.5 mg/L), acetylsalicylic acid (ASA; 62.5 mg/L), sodium bicarbonate (NaHCO 3 ; 75 mg/L), and potassium chloride (KCl; 125 mg/L) in water on heat-exposed broilers. A total of 225 female Ross broiler chickens, 35 d of age, were randomly assigned to 3 treatment groups, with 3 replicates of 25 birds each. The birds were exposed to cyclic temperatures (30 to 33 ° C for 12 h, and 21 to 23 ° C for 12 h) and supplemented with ascorbic acid, ASA, KCl, and NaHCO 3 [heat-stress supplemented (HS-SUP) group], or were exposed to cyclic temperatures (30 to 33 ° C for 12 h, and 21 to 23 ° C for 12 h) but not supplemented [heat-stress nonsupplemented (HS-NON) group]; the other birds were kept under thermoneutral conditions (21 to 23 ° C) and not supplemented (control group). The duration of the experiment was 7 d. Birds in the control group had better ( P < 0.05) live BW and gain, total feed consumption, FCR, and mortality rate (%) than birds in the HS-SUP and HS-NON groups, whereas birds in the HS-SUP group had better ( P < 0.05) live BW and gain, total feed consumption, FCR, and mortality rate (%) than birds in the HS-NON group. The results of this study suggest that ascorbic acid, ASA, KCl, and NaHCO 3 in combination offer a potential protective management practice for preventing heat stress-related depression in the performance of broiler chickens.
PERCEPTION OF CONTOUR: II. EFFECT OF RATE OF CHANGE OF RETINAL INTENSITY GRADIENT

Abstract : Effort was directed to ascertaining the nature of the retinal stimulus effective in producing the perception of an edge under certain simple conditions of photoic foveal vision. A method is described by means of which a distal stimulus is computed which, under the conditions of observation existing, will result in the desired proximal or retinal stimulus. The observer can project a small fiducial dot of light onto the distal stimulus to indicate where an edge, break, contour or discontinuity appears. The study indicated that subjective apparent intensity or brightness is not simply related to the intensity on the retinal and that expression of this phenomenon in terms of the classical concept of the Weber-Fechner fraction, Delta I/I, would result in a positive intensity gradient producing a negative brightness increment. The amount of energy decrement on the retina had little effect upon the appearance of an edge, and the rate of change of energy with respect to retinal distance was an unimportant factor in the production of edges. The second derivative was considered the lowest derivative of energy with respect to retinal distance of substantial significance for contour formation. A fundamental principle is stated to be that a doublet edge may appear substantially symmetrically distributed on either side of a point where the rate of change of the rate of change of intensity on the retina is maximal. The separation of this doublet edge will be smaller the greater the value of the fourth derivative of energy with respect to retinal distance.
Why Don't the Poor Save More? Evidence from Health Savings Experiments

eScholarship provides open access, scholarly publishing services to the University of California and delivers a dynamic research platform to scholars worldwide. Abstract: Using data from a field experiment in Kenya, we document that providing individuals with simple informal savings technologies can substantially increase investment in preventative health and reduce vulnerability to health shocks. Simply providing a safe place to keep money was sufficient to increase health savings, through a mental accounting effect. Adding an earmarking feature was only helpful when funds were put towards emergencies; earmarking for preventative health reduced savings on average, because the liquidity cost of tying up money was too great. Providing social pressure and credit through a ROSCA-based savings scheme had very large effects. Abstract Using data from a ﬁeld experiment in Kenya, we document that providing individuals with simple informal savings technologies can substantially increase investment in preventative health and reduce vulnerability to health shocks. Simply providing a safe place to keep money was suﬃcient to increase health savings by 66%. Adding an earmarking feature was only helpful when funds were put towards emergencies, or for individuals that are frequently taxed by friends and relatives. Group-based savings and credit schemes had very large eﬀects. numerous administrative Seﬁra IRB no relevant or material ﬁnancial relate to the research this paper. All
Classiﬁcation of Tactile and Motor Velocity-Evoked Hemodynamic Response in Primary Somatosensory and Motor Cortices as Measured by Functional Near-Infrared Spectroscopy

: Functional near-infrared spectroscopy (fNIRS) is an emerging technique in studying cerebral hemodynamics; however, consensus on the analysis methods and the clinical applications has yet to be established. In this study, we demonstrate the results of a pilot fNIRS study of cerebral hemodynamic response (HR) evoked by pneumotactile and sensorimotor stimuli on the dominant hand. Our goal is to ﬁnd the optimal stimulus parameters to maximally evoke HR in the primary somatosensory and motor cortices. We use a pulsatile pneumatic array of 14 tactile cells that were attached to the glabrous surface of the dominant hand, with a patterned stimulus that resembles saltation at three distinct traverse velocities [10, 25, and 45 cm / s]. NIRS optodes (16 sources; 20 detectors) are bilaterally and symmetrically placed over the pre-and post-central gyri (M1 and S1). Our objective is to identify the extent to which cerebral HR can encode the velocity of the somatosensory and / or motor stimuli. We use common spatial pattern for feature extraction and regularized-discriminant analysis for classifying the fNIRS time series into velocity classes. The classiﬁcation results demonstrate discriminatory features of the fNIRS signal from each distinct stimulus velocity. The results are inconclusive regarding the velocity which evokes the highest intensity of hemodynamic response.
Diplomarbeit Engineering dark states in hybrid quantum systems ausgeführt am

Hybrid quantum systems combine physical systems with different properties to get the best of both worlds. In our case this means using nitrogen vacancy centers together with superconducting coplanar waveguide resonators. While the resulting system shows promising results, its usage is generally limited by decoherence effects. In this thesis, we want to show a method to improve this by engineering long lived dark states that improve the decay dynamics of our system by a factor 10. This is significantly longer than the cavity or the spin decay, enabling our hybrid quantum system to perform better than its individual parts in this regard. We do this by actively shaping our inhomogeneously broadened spin distribution through the insertion of a high power signal at specific, freely chosen frequencies to excite these spins. The results in this thesis contributed to [Putz15]. We further test our system under strong driving fields and measure spin echos and bistability.
EFFECTS OF EXERCISE AND GAME ON BOY’S PHYSIOLOGY AND SALIVARY ANTIOXIDANT PROPERTIES

Background: This experiment was conducted to determine the exercise effects on anthropometric parameters and salivary antioxidant properties in boys. Material and methods: Saliva samples were collected from fourteen clinically healthy boys (for exercise-07 and game-07 boys). The body temperature, pulse rate (PR), systolic blood pressure (SBP), diastolic blood pressure (DBP) were measured before the exercise and the game as anthropometric parameters. FRAP and DPPH levels were evaluated as the antioxidant parameters of all the saliva samples. Results: Results of two groups‟ viz. exercise and game showed the significantly (p<0.05) increased level of temperature, pulse rate, SBP, and DBP after the workout and game except for the insignificant (p>0.05) increase of pulse rate in the exercise group. Overall anthropometric parameters showed that exercise and game caused physiological stress. Total antioxidant power and total antioxidant scavenging activity were significantly higher after the workout and game. Conclusion: Therefore, from this study, it might be concluded that salivary antioxidant property was changed due to the produced stress after exercise and the game. Meanwhile, in stress, saliva may be useful as the stress biomarker. In the future, the study should be conducted on a large number of volunteers for the changes in the composition of salivary in a different time period of stress due to exercise and game.
Workarounds in the Use of ERP System in SMEs A Case Study from Automotive Industry in Norway

— ERP systems constitute an important solution for most business enterprises. They are robust and effective in what they actually do, but can be hard to tweak for the special needs of Small and Medium Enterprises (SMEs). Alongside the professional use of Information technology (IT) through an ERP system, we therefore often find in-house solutions developed by creative or even ingenious individuals. Those workaround solutions become, however, usually non-standard, silo-prone and less robust than configured standard systems usually are. Sometimes, an in-house system becomes too dependent on individuals continued workplace presence. Sometimes a workaround is obviously ineffective, as when an individual has to take notes manually from one system window, only to feed the notes into a form belonging to another system. We caught interest in the investigation of those kinds of imbalances of IT exploitation, and picked a SME in Norway to execute our research.