Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel Signature Genes and Pathways Identified for Human Left Ventricle Cardiomyopathies Rise from different Etiologies

Cardiomyopathy, a heart disease that arises from different etiologies, places a huge burden on global health care society. Clinical cases of cardiomyopathy were examined independently from the genomic database to identify potential biomarkers and pathways for cardiomyopathy. Exploration of these biopsies as a whole transcription disorder pattern by WGCNA (Weighted Gene Co-expression Network Analysis) to discover signature genes for different cardiomyopathy subtypes. Narrow genes and key pathways correlated with cardiomyopathy traits have been identified through co-expression and protein-protein interaction (PPI) network enrichment analysis. Discovered hub genes have been blast through the Cardiovascular Disease Portal to verify human cardiomyopathy-related functions. Three common axes of signature genes have been identified for five subtypes of cardiomyopathy: 1) Four common genes (MDM4, CFLAR, RPS6KB1, PKD1L2) have been identified for ischemic and ischemic cardiomyopathy subgroups; 2) Subtypes of cardiomyopathy (ischemic, post. partum, familiar and idiopathic) have been shared with eight genes (MAPK1, MAPK11, MAPK14, LMNA, RAC1, PECAM1, XIAP, CREB1); 3) TFAM and RHEB have been identified as the common signature genes for subtypes of cardiomyopathy (viral, post. partum, familiar, and idiopathic) (viral, post. partum, familiar, and idiopathic). Major enriched pathways included the MAPK signaling pathway, the protein processing pathway in the endoplasmic reticulum, and so on. Abnormally regulating these signature genes and pathways caused metabolic process disorders and cellular malfunctions that generally contribute to cardiac dysregulation and functional relapse into cardiomyopathies. In summary, these novel signature genes may work as potential biomarkers for the diagnosis of cardiomyopathy and benefit patients with improved outcomes.
A LEVEL-SET MASS-CONSERVATIVE MESH ADAPTATION TECHNIQUE FOR IN-FLIGHT ICE ACCRETION MULTI-STEP SIMULATIONS

This paper presents an innovative approach to model evolving boundaries problems due to the accumulation or erosion of material over a surface, oﬀering a robust alternative to standard algebraic methods. The strategy is based on the level-set method and it allows the local conservation of the prescribed mass material accounting for the curvature of the body. No partial diﬀerential equations are solved for the level-set function, but simple geometric quantities are used to provide an implicit discretization of the new updated boundary. The method is applied to body-ﬁtted unstructured grids, that allow a good representation of arbitrarily complex geometries. Two multi-step in-ﬂight ice accretion simulations over a NACA0012 are presented to show the feasibility and adaptability of the method, that can be also extended to three-dimensional applications.
The Limit of Public Policy: Endogenous Preferences the Limit of Public Policy: Endogenous Preferences

In designing public policy it is not enough to consider the possible reaction of individuals to the chosen policy. Public policy may also affect the formation of preferences and norms in a society. The endogenous evolution of preferences, in addition to introducing a conceptual difficulty in evaluating policies, may also eventually affect actual behavior. In order to demonstrate the implications of endogenous preferences on the design of optimal public policy, we present a model in which a subsidy policy is set to encourage contributions towards a public good. However this policy triggers an endogenous preference change that results in a lower level of contribution towards the public good despite the explicit monetary incentives to raise that level. 2 " Social scientists – especially economists – evaluate policies and institutions by examining behavioral responses to incentives, with values, habits, and social norms taken as given and beyond analysis and the reach of public policy " Aaron (1994)
Systemic Operations Management of Imo State Tourism Industry: A Focus on Improving Corporate Performance Through Human Capital Development

his study investigated systemic operations management in tourism T organizations, with a focus on improving corporate performance through human capital development. It was based on 15 tourism organizations in Imo State of Nigeria's tourism industry. The respondents comprised 15 managers and 75 customers of these organizations purposefully and accidentally selected respectively. The studies sought to establish the nexus between human capital development and corporate performance; and use the result to buttress the need for managing tourism organizations from the systemic operations management perspective. The result indicated strong positive correlations between the dimensions of human capital development (training and mentoring) and the measures of corporate performance (productivity and protability). It was concluded that systemic operations management anchored on human capital development enhances employee performance and lead to improved corporate performance. Furthermore, training and mentoring are key development programs that are capable of improving productivity and protability. Consequently, the study recommended that managers and executives wishing to improve their corporate performance, should endeavour to practice systemic operations management anchored on human capital development. they should establish well thought-out development programs aimed at improving employee skills and competencies. They should intentionally and regularly subject their staff to training and mentoring programs so as to help in improving corporate productivity and protability. They should however beware of the extent to which they can achieve improvement on corporate performance through human capital development; and be able to control for exogenous factors that are capable of limiting their desired results.
The I/O complexity of Strassenâs matrix multiplication with recomputation

A tight Ω (( n/ √ M ) log 2 7 M ) lower bound is derived on the I/O complexity of Strassen’s algorithm to multiply two n × n matrices, in a two-level storage hierarchy with M words of fast memory. A proof technique is introduced, which exploits the Grigoriev’s ﬂow of the matrix multiplication function as well as some combinatorial properties of the Strassen computational directed acyclic graph (CDAG). Applications to parallel computation are also developed. The result generalizes a similar bound previously obtained under the constraint of no-recomputation, that is, that intermediate results cannot be computed more than once.
Conserved Extracellular Cysteines Differentially Regulate the Conserved Extracellular Cysteines Differentially Regulate the Potentiation Produced by Zn2+ in Rat P2X4 Receptors Potentiation Produced by Zn2+ in Rat P2X4 Receptors

: One feature of the amino acid sequence of P2X receptors identified from mammalian species, Xenopus laevis and zebrafish is the conservation of ten cysteines in the extracellular loop. Little information is available about the role of these conserved ectodomain cysteines in the function of P2X receptors. Here, we investigated the possibility that ten conserved cysteine residues in the extracellular loop of the rat P2X4 receptor may regulate zinc potentiation of the receptor using a series of individual cysteine to alanine point mutations and functional characterization of recombinant receptors expressed in Xenopus oocytes. For the C116A, C132A, C159A, C165A, C217A and C227A mutants, 10 μM zinc did not significantly affect the current activated by an EC 40 concentration of ATP. By contrast, 5 μM zinc shifted the ATP concentration-response curve to the right in a parallel manner for both the C261A and C270A mutants and the magnitudes of those shifts were similar to that of the wildtype receptor. Interestingly, for the C126A and C149A mutants, 5 μM zinc potentiated ATP-activated current, but increased the maximal response to ATP by by 90% and 81% respectively, without significantly changing the EC 50 value of ATP. Thus, these results suggest that cysteines and disulfide bonds between cysteines are differentially involved in the potentiation of the rat P2X4 receptor by zinc
University of Birmingham Decomposition of arrow type positive semidefinite matrices with application to topology optimization

Decomposition of large matrix inequalities for matrices with chordal sparsity graph has been recently used by Kojima et al. (Math Program 129(1):33–68, 2011) to reduce problem size of large scale semideﬁnite optimization (SDO) problems and thus increase efﬁciency of standard SDO software. A by-product of such a decomposition is the introduction of new dense small-size matrix variables. We will show that for arrow type matrices satisfying suitable assumptions, the additional matrix variables have rank one and can thus be replaced by vector variables of the same dimensions. This leads to signiﬁcant improvement in efﬁciency of standard SDO software. We will apply this idea to the problem of topology optimization formulated as a large scale linear semideﬁnite optimization problem. Numerical examples will demonstrate tremendous speed-up in the solution of the decomposed problems, as compared to the original large scale problem. In our numerical example the decomposed problems exhibit linear growth in complexity, compared to the more than cubic growth in the original problem formulation. We will also give a connection of our approach to the standard theory of domain decomposition and show that the additional vector variables are outcomes of the corresponding discrete Steklov–Poincaré operators.
The strawberry guava: a new fruit species for humid areas in Reunion island

The strawberry guava (#Psidium cattleianum# Sabine) is a shrub naturalised in several subtropical areas. It produces sweet and aromatic fruit which are appreciated by the inhabitants of the Reunion Island. Processing industries are supplied by fruit gathered in the wild. As strawberry guava thrives well in humid areas where the farming potential is low, its cultivation can become a means to provide additional incomes to fanners, to secure the supply with fruit to industries and to develop the market. Very little information about cropping techniques being available from the literature, a domestication program has been engaged. Variability among plants is of very limited extent so that there was no need to start with a selection program. On farm trials have been established at different elevations and both technical and economical data have been recorded. Some results about the influence of ecological and agronomic factors on growth, yield and fruit quality, as well as data on economics, are presented. The first production occurs as early as two years after plantation and the potential production is high. Fruit quality is affected by fruit load, cultural practices and weather and could be improved by proper crop management. Strawberry guava appears as a profitable fruit crop in humid areas of Reunion Island. The need for further studies for a more effective management of yield and fruit quality is stressed. (Resume d'auteur)
Applying the Framework for Culturally Responsive Teaching to Explore the Adaptations That Teach First Beginning Teachers Use to Meet the Needs of Their Pupils in School about the Author Public Interest Statement

Previous research has shown that beginning teachers are capable of adapting their practice to the needs of ethnically diverse pupils. This paper investigates the possibility that such teachers were developing their practice into what I have termed culturally adaptive teaching. A variety of methods were used to collect qualitative data that focused on the perspectives of teachers in schools across Yorkshire and Humberside, (UK) over the course of an academic year. The framework for culturally responsive teaching (CRT) was used as a lens through which to analyse the data collected. It enabled findings to emerge that took the framework beyond that of CRT, to one of culturally adaptive teaching. Teachers continually adapted their practice, in terms of cultural sensitivity, to better meet the needs of their pupils. If we can apply this framework and support beginning teachers to help them understand issues of cultural diversity in the classroom, we might be able to engender a real systematic change in teaching for the benefit of pupils. Alison Hramiak is a senior lecturer in Education at Sheffield Hallam University, working primarily with Trainee Teachers in the Teach First programme, where she is the Regional ICT Subject Lead for Yorkshire and Humberside. She also teaches on the masters and doctoral Courses at the university. Her research interests focus on the cultural adaptations of Teach First beginning teachers as they are placed in challenging schools that are often very different from anything they have experienced before. The research in this paper builds on previous work in this field both in the UK and in America, looking at ways to better prepare beginning teachers for the challenges they face in a multicultural environment, by exploring the adaptations in pedagogy made by teachers as they develop through the academic year—their first year of teaching. It also seeks ways to apply the research to a wider audience, such as other types of trainee teachers, and possibly other professions where placements are similarly challenging. This research looks at the ways in which beginning teachers adapt their teaching for pupils of different ethnic origins and backgrounds. It was conducted to try to seek ways to improve teacher training, to provide more informed guidance for beginning teachers as they face challenges in schools that are very different from what they have experienced before. The study builds on previous research by the author, extending the work and exploring the development of …
Ammonium nitrogen in surface soil of arid and semiarid Central East Asia

Ammonium nitrogen in soil is an important component of mineralized nitrogen,which can be absorbed and utilized by vegetation directly.Changes of-N concentration have relationship with many biochemical processes of nitrogen circle,thus a significant part in nitrogen biogeochemistry.There are various factors influencing-N concentration,however,the major factor is uncertain.With excellent gradients of vegetation and soil type zone,as well as gradients of temperature and precipitation,Central East Asia provides an ideal background for developing the relationship between Ammonium nitrogen and the climatic parameters.Analysis of surface soil from a transect that crosses the various climatic and vegetation zones reveals a significant linear correlation between-N and the mean temperature from May to September,yet a very poor relationship between-N and precipitation.And a close correlation between-N and the soil pH value is also observed.These results indicate that both variation of temperature and soil pH value are key factors affecting soil ammonium nitrogen,while the precipitation plays a short,quick,and rush impact.
FATTY ACIDS AND HYDROCARBONS OF CARIBBEAN CORALS

Lipid components have been characterized from 45 coral samples representing 27 scleractinian and 1 hydrozoan Caribbean species. The f a t t y acid compositions of most samples are low i n polyunsaturated 'components. This is exceptional f o r marine animals. However, 6 samples from deeper locations con-t a i n r e l a t i v e l y high amounts of polyunsaturated acids, revealing t h a t these marine-type acids do occur i n corals. Distinctive f a t t y acid compositions e x i s t a t the species l e v e l , and often close similari-t i e s a r e found between species within a genus. Substantial temporal and geographical variations can be superimposed upon these distinctive patterns. While concentrations of t o t a l unsaturated hydrocarbons a r e nearly the same a s those of t o t a l f a t t y acids, levels of saturated hydrocarbons a r e several orders of magnitude lower. Less than half the saturated hydrocarbons of these organisms is comprised of n-alkanes. No odd-carbon dominance is exhibited by these hydrocarbons.
Augmented Reality Chemistry: Transforming 2-D Molecular Representations into Interactive 3-D Structures

Spatial reasoning is defined as the ability to generate, retain, and manipulate abstract visual images. In chemistry, spatial reasoning skills are typically taught using 2-D paper-based models, 3-D handheld models, and computerized models. These models are designed to aid student learning by integrating information from the macroscopic, microscopic, and symbolic domains of chemistry. Research has shown that increased spatial reasoning abilities translate directly to improved content knowledge. The recent explosion in the popularity of smartphones and the development of augmented reality apps for them provide, a yet to be explored, way of teaching spatial reasoning skills to chemistry students. Augmented reality apps can use the camera on a smartphone to turn 2-D paper-based molecular models into 3-D models the user can manipulate. This paper will discuss the development, implementation, and assessment of an augmented reality app that transforms 2-D molecular representations into interactive 3-D structures. Abstract Spatial reasoning is defined as the ability to generate, retain, and manipulate abstract visual images. In chemistry, spatial reasoning skills are typically taught using 2-D paper-based models, 3-D handheld models, and computerized models. These models are designed to aid student learning by integrating information from the macroscopic, microscopic, and symbolic domains of chemistry. Research has shown that increased spatial reasoning abilities translate directly to improved content knowledge. The recent explosion in the popularity of smartphones and the development of augmented reality apps for them provide, a yet to be explored, way of teaching spatial reasoning skills to chemistry students. Augmented reality apps can use the camera on a smartphone to turn 2-D paper- based molecular models into 3-D models the user can manipulate. This paper will discuss the development, implementation, and assessment of an augmented reality app that transforms 2-D molecular representations into interactive 3-D structures. however, suggest that the inclusion of the augmented reality activity did not negatively impact student learning. These results, combined with the enthusiastic response of the students as they interacted with the Aurasma app, indicate that augmented reality based molecular models have a future in the chemistry positive student performance results are further validated when their opinions
UvA-DARE (Digital Academic Repository) Fifth Workshop on Exploiting Semantic Annotations in Information Retrieval (

There is an increasing amount of structure on the Web as a result of modern Web languages, user tagging and annotation, emerging robust NLP tools, and an ever growing volume of linked data. These meaningful, semantic, annotations hold the promise to signiﬁcantly enhance information access, by enhancing the depth of analysis of today’s systems. Currently, we have only started exploring the possibilities and only begin to understand how these valuable semantic cues can be put to fruitful use. To complicate matters, standard text search excels at shallow information needs expressed by short keyword queries, and here semantic annotation contributes very little, if anything. The main questions for the workshop are how to leverage the rich context currently available, especially in a mobile search scenario, giving powerful new handles to exploit semantic annotations. And how can we fruitfully combine information retrieval and semantic web approaches, and for the ﬁrst time work actively toward a uniﬁed view on exploiting semantic annotations.
Strategies for Sustainable Agricultural Development in the Ethiopian Highlands

This paper investigates the impacts of population growth, market access, agricultural credit and technical assistance programs, land policies, livelihood strategies and other factors on changes in land management, natural resource conditions and human welfare indicators since 1991 in the northern Ethiopian highlands, based on a survey of 198 villages. We find that population growth has contributed significantly to land degradation, poverty and food insecurity in this region. In contrast, better market access and some credit and technical assistance programs were associated with improvement (or less decline) in land quality, wealth and food security; suggesting the possibility of “win-win-win” development outcomes with appropriate interventions. Land redistribution was associated with adoption of inorganic fertilizer, but also with declining use of fallow and declining soil fertility. We find also that different land management practices are adopted where different livelihood strategies are pursued, suggesting the importance of considering livelihood strategies in technical assistance programs. Development strategies should be tailored to the different comparative advantages of different locations; no “one-size-fits-all” strategy will work everywhere.
A survey of an ectotrophic sand dune forest in the northeast Brazil

Ectomycorrhizal (ECM) species are poorly known from tropical lowlands of South America. Recent systematic surveys in the reserve Parque Estadual das Dunas do Natal, in the state of Rio Grande do Norte, Brazil, using a purposive sampling approach revealed new and yet undocumented community of ectomycorrhizal fungi in the reserve. Collections made in areas with a ectotrophic tree genera present next to the established walking paths revealed six genera of putative ECM fungi. These fungi belong to the Basidiomycota family Amanitaceae, Boletaceae, Hymenochaetaceae, Russulaceae and Sclerodermataceae, all of which are poorly documented from Brazil. The study contributed to the fungal diversity in an ectotrophic sand dune forest in the northeast Brazil, necessary for better understanding of the role of these organisms and their impact in the ecosystem. Discoveries opened additional questionings about the distribution, ecology and taxonomy of the ectomycorrhizal genera in tropical moist broadleaf forests.