Miracle-dz/UniFAR-FTUs huggingface dataset:
Proteomic Profiling Skin Mucus of European Eel Anguilla anguilla Infected with Anguillid Herpesvirus

Anguillid herpesvirus 1 (AngHV) is an important viral pathogen affecting eel. This study was designed to investigate the potential molecular mechanisms and immune response elicited at the protein levels in the skin mucus of AngHV-infected Anguilla anguilla. Tandem mass tag (TMT)-labelling proteomics with the liquid chromatography tandem mass spectrometry (LC-MS/MS) was used for performing quantitative identification of the proteins. In addition, the quantitative protein amount was detected by parallel reaction monitoring (PRM) analysis. A total of 3486 proteins were identified, of which 2935 were quantified. When a protein fold change was greater than 1.3 or less than 0.76, it indicated a differentially expressed protein (DEP). Overall, 187 up-regulated proteins and 126 down-regulated proteins were detected, and most of the DEPs were enriched in the CAMs pathway, intestinal immune pathway, herpes simplex virus 1 infection pathway, phagosome pathway and p53 signaling pathway. The results of the DEPs detected by PRM were highly consistent with the results of the TMT-labelled quantitative proteomic analysis. The findings of this study provide an important research basis for further understanding the pathogenesis of AngHV.
Power Option Pricing Based on Time-Fractional Model and Triangular Interval Type-2 Fuzzy Numbers

The problem of generalizing the power option-pricing model to incorporate more empirical features becomes an urgent and necessary event. A new power option pricing method is designed for the financial market uncertainty that simultaneously involves randomness and fuzziness. The randomness in market uncertainty is modeled by a time-fractional diffusion model, which describes trend memory in underlying asset prices. The fuzziness in market uncertainty is characterized by a triangular interval type-2 fuzzy numbers, which better captures the fuzziness of underlying asset prices. Considering the decision-maker’s subjective judgment, we show the price mean value with the possibility-necessity weight and pessimistic-optimistic index under the type-2 fuzzy environment. We develop the power option pricing model with the time-fractional diffusion model and the triangular interval type-2 fuzzy numbers. Furthermore, the analytic solutions of pricing call power option and put power option are obtained and verified by the variational iterative reconstruction method. Our study shows that power option pricing, which adopts the time-fractional model and the triangular interval type-2 fuzzy numbers, can better capture the trend memory and double fuzziness of the real market. In addition, a numerical example is provided to illustrate that the power option means the value is decreasing with respect to the pessimistic-optimistic index and is fluctuating with respect to the possibility-necessity weight index.
Kinematics and Formation Mechanisms of High-Redshift Galaxies

Recent years have witnessed a substantial increase in our ability to trace the spatially resolved properties of rapidly star-forming galaxies in the high-redshift universe and numerous studies have suggested the importance of turbulent gas-phase kinematics. In this submission to the Astro 2010 Decadal survey we outline some of the major outstanding questions regarding the kinematics and formation history of these galaxies, such as the prevalence of various kinematic models, the relation to lower surface-brightness populations and faint AGN, and the implications for the evolution of gas accretion and cooling mechanisms with redshift. We comment on the capability of future large optical/IR and millimeter wavelength facilities to address these questions.
Bioprinting of 3D Adipose Tissue Models Using a GelMA-Bioink with Human Mature Adipocytes or Human Adipose-Derived Stem Cells

Adipose tissue is related to the development and manifestation of multiple diseases, demonstrating the importance of suitable in vitro models for research purposes. In this study, adipose tissue lobuli were explanted, cultured, and used as an adipose tissue control to evaluate in vitro generated adipose tissue models. During culture, lobule exhibited a stable weight, lactate dehydrogenase, and glycerol release over 15 days. For building up in vitro adipose tissue models, we adapted the biomaterial gelatin methacryloyl (GelMA) composition and handling to homogeneously mix and bioprint human primary mature adipocytes (MA) and adipose-derived stem cells (ASCs), respectively. Accelerated cooling of the bioink turned out to be essential for the homogeneous distribution of lipid-filled MAs in the hydrogel. Last, we compared manual and bioprinted GelMA hydrogels with MA or ASCs and the explanted lobules to evaluate the impact of the printing process and rate the models concerning the physiological reference. The viability analyses demonstrated no significant difference between the groups due to additive manufacturing. The staining of intracellular lipids and perilipin A suggest that GelMA is well suited for ASCs and MA. Therefore, we successfully constructed physiological in vitro models by bioprinting MA-containing GelMA bioinks.
Effect of Yoga and Mindfulness Intervention on Symptoms of Anxiety and Depression in Young Adolescents Attending Middle School: A Pragmatic Community-Based Cluster Randomized Controlled Trial in a Racially Diverse Urban Setting

Mental health conditions in childhood and adolescence are increasing in the U.S. population and require early intervention, as highlighted by a recent Surgeon General’s Advisory on Protecting Youth Mental Health. These health issues, which have been exacerbated by the COVID-19 pandemic, impair functioning, and may lead to longer term reductions in quality of life. Young adolescents are likely to experience stressors including academic pressure, feelings of loneliness and isolation, and excessive exposure to social media, all of which have been made worse by the pandemic and associated disruptions. Universal preventive programs at school serve as an important strategy for equipping youth with coping skills to address current and future social and emotional challenges. Yoga and mindfulness programs have emerged as a promising preventive approach for schools and have proven feasible and acceptable. The current study evaluated a universal, school-based mindfulness and yoga program among youth aged 11–14 in a racially diverse, urban setting in the United States. Outcomes of interest included symptoms of anxiety and depression. Anxiety and depression symptoms decreased in the intervention group, although these differences were not statistically significant. In the control group, anxiety symptoms decreased but depression symptoms increased. The resulting time effect indicated a significant decrease in anxiety symptoms, while the time by group effect revealed a strong trend in depression symptoms. Future research should investigate the utility of yoga and mindfulness interventions for early adolescents in a larger population, and the differences in intervention effect among subgroups, with attention to longer term outcomes.
Influence of Occupation on the Prevalence of Spinal Pain among Physiotherapists and Nurses

(1) Background: Neck pain (NP) and low back pain (LBP) are common musculoskeletal disorders, one of the major causes of disability globally. The aim of the study was to determine the influence of medical occupation (physiotherapist and nurse) on the prevalence of spinal pain, functional status and degree of disability. (2) Methods: a total of 544 people (462 females (84.9%) and 82 males (15.1%)), licensed to practice as a physiotherapist (n1 = 240 (44.1%)) or nurse (n2 = 304 (55.9%)) in Poland completed a special questionnaire designed by the authors of the study, and were assessed using the Neck Disability Index (NDI, Polish language version) and Revised Oswestry Disability Index (ODI, Polish language version). (3) Results: Compared to physiotherapists, nurses were older, shorter, had higher BMI, and longer work experience. In the whole study group, 30.2% of subjects reported NP, 17.7% reported thoracic pain (ThP) and 80.5% reported LBP. During working life, 90.9% of physiotherapists and 97.7% of nurses experienced spinal pain. Pain intensity measured with Visual Analogue Scale (VAS) was higher among nurses (mean 5.37) than among physiotherapists (mean 4.64). Nurses had a higher degree of disability caused by LBP and NP measured with ODI and NDI compared to physiotherapists. (4) Conclusions: Excessive strain of the spine associated with occupational activities has a strong impact on the intensity and frequency of spinal pain episodes. Physiotherapists and nurses mainly suffer from low back pain. Pain scores measured with VAS are higher in nurses than in physiotherapists.
Incidence and Risk Factors for Low Birthweight and Preterm Birth in Post-Conflict Northern Uganda: A Community-Based Cohort Study

Background: Annually, an estimated 20 million (13%) low-birthweight (LBW) and 15 million (11.1%) preterm infants are born worldwide. A paucity of data and reliance on hospital-based studies from low-income countries make it difficult to quantify the true burden of LBW and PB, the leading cause of neonatal and under-five mortality. We aimed to determine the incidence and risk factors for LBW and preterm birth in Lira district of Northern Uganda. Methods: This was a community-based cohort study, nested within a cluster-randomized trial, designed to study the effect of a combined intervention on facility-based births. In total, 1877 pregnant women were recruited into the trial and followed from 28 weeks of gestation until birth. Infants of 1556 of these women had their birthweight recorded and 1279 infants were assessed for preterm birth using a maturity rating, the New Ballard Scoring system. Low birthweight was defined as birthweight <2.5kg and preterm birth was defined as birth before 37 completed weeks of gestation. The risk factors for low birthweight and preterm birth were analysed using a multivariable generalized estimation equation for the Poisson family. Results: The incidence of LBW was 121/1556 or 7.3% (95% Confidence interval (CI): 5.4–9.6%). The incidence of preterm births was 53/1279 or 5.0% (95% CI: 3.2–7.7%). Risk factors for LBW were maternal age ≥35 years (adjusted Risk Ratio or aRR: 1.9, 95% CI: 1.1–3.4), history of a small newborn (aRR: 2.1, 95% CI: 1.2–3.7), and maternal malaria in pregnancy (aRR: 1.7, 95% CI: 1.01–2.9). Intermittent preventive treatment (IPT) for malaria, on the other hand, was associated with a reduced risk of LBW (aRR: 0.6, 95% CI: 0.4–0.8). Risk factors for preterm birth were maternal HIV infection (aRR: 2.8, 95% CI: 1.1–7.3), while maternal education for ≥7 years was associated with a reduced risk of preterm birth (aRR: 0.2, 95% CI: 0.1–0.98) in post-conflict northern Uganda. Conclusions: About 7.3% LBW and 5.0% PB infants were born in the community of post-conflict northern Uganda. Maternal malaria in pregnancy, history of small newborn and age ≥35 years increased the likelihood of LBW while IPT reduced it. Maternal HIV infection was associated with an increased risk of PB compared to HIV negative status. Maternal formal education of ≥7 years was associated with a reduced risk of PB compared to those with 0–6 years. Interventions to prevent LBW and PBs should include girl child education, and promote antenatal screening, prevention and treatment of malaria and HIV infections.
Three-Dimensional Hybrid Simulation of Mode Conversion at the Magnetopause

[1] Two-dimensional hybrid simulations are used to investigate how fast-mode compressional waves incident on a magnetopause current layer mode convert both linearly and nonlinearly to short wavelength (k⊥ρi ∼ 1) kinetic Alfven waves near the Alfven resonance surface. The background magnetic fields on both sides of the current layer are parallel to each other and perpendicular to the magnetopause normal, corresponding to a northward interplanetary magnetic field. The simulations are performed in a 2-D plane (xz), where x is normal to the magnetopause and z is tilted by an angle, θ, relative to the magnetic field. We examine how the mode conversion depends on wave frequency ω0, wave vector, Alfven velocity profile (particularly the magnetopause width, D0), ion β in the magnetosheath, electron-to-ion temperature ratio, and incident wave amplitude. Kinetic effects resolve the resonance, and KAWs radiate back to the magnetosheath side of the current layer. The compressional wave absorption rate is estimated and compared with linear theory. Unlike the prediction from low-frequency theory of the Alfven resonance, KAWs are also generated in cases with θ = 0°, provided ω0 > 0. 1Ω0, with Ω0 being the ion cyclotron frequency in the magnetosheath. As the incident wave amplitude is increased, several nonlinear wave properties are manifested in the mode conversion process. Harmonics of the driver frequency are generated. As a result of nonlinear wave interaction, the mode conversion region and its spectral width are broadened. The nonlinear waves provide a significant transport of momentum across the magnetopause and are associated with significant ion heating in the resonant region.
The “Tough Road” of Inheriting Intangible Cultural Heritage in the Age of Digital Media: Taking Dunhuang Art Academy as an Example

Dunhuang intangible cultural heritage is an important form of Chinese traditional culture and the track of the accumulation of Chinese civilization. As a display platform for the export of Dunhuang culture, Dunhuang Art Academy has few scholars to study it. Therefore, based on the various opportunities and challenges posed by the works of Dunhuang Art Academy in the process of preservation, inheritance, and innovation, this paper takes the intangible cultural heritage of Dunhuang Art Academy as an example, focusing on the protection of inheritance, innovation realization in the digital society. The omni media development of Dunhuang Art Academy is discussed from four aspects: simulacra, education, media, and value realization, in order to obtain some new explorations and inspirations for expanding Dunhuang's intangible cultural heritage.
Research on the Mechanical Behavior of Buried Double-Wall Corrugated Pipes

The mechanical behavior of buried HDPE double-wall corrugated pipes is mainly affected by the material and the structure of the pipe wall. Here we studied a peculiar material that added fly ash (FA) in high density polyethylene (HDPE) to develop composites. We have conducted research on FA/HDPE composites with different mix proportions. When 5% compatibilizer was added to the 10% FA masterbatch/HDPE composite, the Young’s Modulus of FA/HDPE composite was higher. This paper mainly studies the mechanical behavior of the structure of pipe walls for materials with this proportion of the ingredients. The mechanical behavior of double-wall corrugated pipes with different ratios of interior and exterior wall thicknesses is studied by keeping the sum of the interior and exterior wall thicknesses unchanged. Pipes with six different ratios of interior and exterior wall thicknesses are simulated; the results show that the strain of crest and liner gradually decreased and the valley strain gradually increased with the increase of the exterior wall thickness. By comparing inner and outer wall thickness ratios from 0.67 to 2.33, it is found that the structural performance and economic advantage for the double-wall corrugated pipes is best when the thickness ratio of the interior wall and the exterior wall is controlled to be from 1.3 to 1.8. This paper expounds the deformation mechanism of double-wall corrugated pipes from the perspective of mechanical behavior and structural characteristics, and provides a reference for material selection and structural design of double-wall corrugated pipes.
Taxonomic and palaeobiological implications of a large, pathological sabretooth (Carnivora, Felidae, Machairodontinae) from the Lower Pliocene of South Africa

We describe the most complete postcranial remains of a pathological, large‐bodied sabretooth from the Lower Pliocene site of Langebaanweg ‘E’ Quarry (South Africa). The skeleton consists of hind limb and vertebral elements that exhibit distinctive exostoses, osteophytes and eburnation. We performed a quantitative morphological comparison of the new postcranial remains found in Langebaanweg, with other Neogene and Quaternary sabretooth and non‐sabretooth felids, consisting of the genera Amphimachairodus, Machairodus, Lokotunjailurus, Dinofelis, Panthera, Homotherium and Smilodon from several sites in Africa, Europe and North America, using principal component analysis and Mosimann transformations. Although the pathological deformation of the remains distorted some of the linear measurements, most of the analysed variables do not contain pathological features, and strongly indicate that the Langebaanweg sabretooth is morphologically closer to Machairodus aphanistus and Lokotunjailurus emageritus than it is to Amphimachairodus giganteus. This indicates that the remains could belong to an undetermined sabretooth species from the Langebaanweg locality. The observed pathologies in the foot and lumbar spine are consistent with diagnostic criteria for severe osteoarthritis (due to maturity), which would have limited limb mobility with severe consequences for hunting success.
Temperature and Humidity Sensitivity of Polymer Optical Fibre Sensors Tuned by Pre-Strain

Polymer optical fibre Bragg grating (POFBG) sensors are of high interest due to their enhanced fracture toughness, flexibility in bending, and sensitivity in stress and pressure monitoring applications compared to silica-based sensors. The POFBG sensors can also detect humidity due to the hydrophilic nature of some polymers. However, multi-parameter sensing can cause cross-sensitivity issues in certain applications if the temperature and humidity measurements are not adequately compensated. In this work, we demonstrate the possibility of selectively tuning sensors’ temperature and humidity sensitivities to the desired level by applying a certain amount of fibre pre-strain. The temperature sensitivity of POFBG sensors fabricated in perfluoropolymers (CYTOP) can be selectively tuned from positive to negative values, having the option for insensitivity in specific temperature ranges depending on the amount of the applied pre-strain. The humidity sensitivity of sensors can also be changed from positive values to insensitivity. The importance of thermal annealing treatment of POFBG sensors for improved repeatability in temperature measurements is also reported. An array of 4 multiplexed POFBGs was fabricated, and each sensor was pre-strained accordingly to demonstrate the possibility of having targeted temperature and humidity sensitivities along the same fibre.
Evaluation of 3,5-Diphenyl-2-Pyrazolines for Antimitotic Activity by Inhibition of Tubulin Polymerization

Chalcones have a skeleton of diphenyls connected via an α,β-unsaturated carbonyl group. Many chalcone derivatives have been shown to interact with tubulin. Based on previous reports, chalcones derived by substitution of a carbonyl group with 2-pyrazoline can be expected to inhibit tubulin polymerization. Therefore, 3,5-diphenyl-2-pyrazolines were prepared to investigate their ability to inhibit tubulin polymerization. The clonogenic long-term survival assay showed that derivative 4, 5-(3,5-dimethoxyphenyl)-3-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide, was the most effective at inhibiting the clonogenicity of HCT116 human colon cancer cells. Derivative 4 induced G2/M cell cycle arrest. In addition, derivative 4 caused dispersed microtubules, a disorganized spherical arrangement of chromosomes, and inhibition of mitotic spindle formation. The binding mode between tubulin and derivative 4 was elucidated by in silico molecular docking. Derivative 4 was superimposed with colchicine and entered the colchicine-binding site well. These results suggest that derivative 4 inhibits tubulin polymerization by binding to the colchicine binding site of tubulin, thus preventing mitotic spindle formation during mitosis in HCT116 colon cancer cells. We propose that derivative 4 could be used as a promising antimitotic chemotherapeutic agent.
Nanoscale Electro-Photonic Tweezer for Terahertz Monitoring of Dynamic Assembly of Nanoparticles under Aqueous Environment

The probing technique of the evolution of nanoparticle (NP) assembly in an aqueous environment is essential to understanding the phase evolution of the NPs in the nanoscale. Terahertz (THz) sensing with resonant structures has emerged as a high-sensitive sensing platform with unique characteristics including label-free and non-destructive manner. Nevertheless, the high absorption of liquid severely hindered direct underwater detection. Here we suggest the THz monitoring device using vertically aligned double layers of nanoslot-hybridized metamaterial which can capture and detect the NPs simultaneously. Combining the electrical tweezing techniques with spatially overlapped optical hotspots, will give powerful methods of advanced surface-sensitive biosensors.
Increasing Doses of Bacterial Phytase (Citrobacter braakii) Improves Performance and Carcass Characteristics of Pigs in Growing and Finishing Phases

Simple Summary Phytases of bacterial origin are the exogenous enzymes most widely used in the diets of monogastric animals, acting on the hydrolysis of phytate (myo-inositol 1,2,3,4,5,6-hexakis [dihydrogen] phosphate) to release the phosphate from this complex. However, the efficiency of phytase varies according to the aspects inherent to its own structure and origin, the age and physiological state of the animal, and the dietary composition. Overall, we found that supplementation with phytase between 1500 and 3000 units of phytase (FYT)/kg of feed in diets based on corn and soybean meal with a reduction in inorganic phosphorus (0.13%) and calcium (0.11%) improves the daily weight gain (DWG) and live weight (LW) of animals in the growing phase, which affects performance on finishing phases and slaughter body weight. This input could result in a reduction in the use of phosphorus sources, improving environmental issues with an increase in the main zootechnical parameters. Abstract The effects of increasing doses of bacterial phytase (Citrobacter braakii) on performance and carcass characteristics of growing-finishing pigs was evaluated. A total of 120 barrows weighing 25.16 ± 2.80 kg and 68 days old were submitted to five treatments: positive control diet (PC) containing inorganic phosphorus (P) and limestone (Ca); negative control (NC) with reductions in P (by 0.13%) and Ca (by 0.11%); and three NC diets supplemented with 1500 (NC15), 3000 (NC30) and 4500 (NC45) units of phytase (FYT)/kg. The daily weight gain (DWG) in growth phase I (68–91 days) was higher in the PC, NC15 and NC30, compared to the NC (1.06, 1.06, 1.06 vs. 0.95, respectively). The DWG in finishing phase II (141–156 days) was higher in the NC15 (1.20 kg) and NC30 (1.14 kg) than in the NC45 (0.94 kg). The final weights (LW156) in the NC15 (122.95 kg LW) were higher than NC (116.47 kg LW) and NC45 (114.43 kg LW). Over the entire period, a quadratic effect (2012 FYT) was observed for the DWG. The increasing levels of phytase in corn and soybean meal-based diets improved the DWG and carcass traits; however, the addition of more than 3000 FYT/kg of feed should be carefully studied to determine enzyme viability.