Miracle-dz/UniFAR-FTUs huggingface dataset:
Plasmin-derived M 2 macrophages produce 2 key effector processes for the resolution of in fl ammation : annexin A 1 and neutrophil efferocytosis

Resolution of inflammation is a key physiological process regulated at different levels, and failure to achieve resolution may result in chronic inflammation. In this issue of Blood, Sugimoto et al reveal the function of the plasmin system in resolving inflammation by inducing macrophage polarization toward M2 and proresolving phenotypes. Plasmin-derived M2 macrophages produce 2 key effector processes for the resolution of inflammation: annexin A1 and neutrophil efferocytosis.
Effects of resveratrol treatment on cardiac remodeling following myocardial infarction

Background: Resveratrol (RES) has been shown to improve health and slow the progression of disease in various models. Several cardioprotective mechanisms have been identified including antioxidant, anti-inflammatory, and anti-fibrotic actions. Each of these actions is thought to have the ability to attenuate the pathophysiology underlying the deleterious cardiac structural remodeling which results from acute myocardial infarction (MI). We therefore evaluated the effect of resveratrol treatment on the progression of cardiac remodeling after MI. Methods and Results: Four groups of rats (Sham, N=6; Sham+RES, N=21; MI, N=26; MI+RES, N=24) were treated for 13 weeks, starting 7 days before ligation of the left anterior descending coronary artery. Serial transthoracic echocardiography revealed that resveratrol had no effect on MI-induced leftventricular and left-atrial dilatation or reduction in left-ventricular fractional shortening. Consistent with these findings, resveratrol did not improve the deterioration of hemodynamic function or reduce infarct size at 12 weeks post-MI. Resveratrol-treated animals did, however, show preserved cardiac contractile reserve in response to dobutamine administration. Radioligand binding revealed that MI reduced β-adrenergic receptor density. Resveratrol administration increased β-adrenoceptor density, so that resveratrol-treated MI rats had β-adrenoceptor densities similar to normal rats. Real-time RT-PCR revealed that MI-induced changes in SERCA-2 and transforming growth factor beta-1 (TGFβ1) expression were unaltered by reseveratrol, whereas MI-induced increases in atrial natriuretic factor (ANF) and connective tissue growth factor (CTGF) expression were attenuated. Conclusions: Resveratrol treatment does not improve cardiac remodeling and global hemodynamic function post-MI, but does preserve contractile reserve and attenuate ANF and CTGF upregulation. This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on September 17, 2007 as DOI: 10.1124/jpet.107. 127548 at A PE T Jornals on A uust 7, 2017 jpet.asjournals. org D ow nladed from
Spectrum of Restrictive and Infiltrative€Cardiomyopathies

Ma Restrictive cardiomyopathies are the least common form of heart muscle disease. They are characterized as infiltrative and noninfiltrative, storage diseases, and endomyocardial disorders. Genetic diseases commonly present during childhood or adolescence. However, a growing percentage of elderly patients with heart failure with preserved ejection fraction are being recognized as having forms of restrictive cardiomyopathy, particularly cardiac amyloidosis. Noninvasive evaluation has replaced endomyocardial biopsy in the diagnostic evaluation of most suspected etiologies. The detection of infiltrative cardiomyopathies, including lysosomal and glycogen storage disorders, iron overload, and amyloidosis (both light chain amyloidosis and transthyretin amyloidosis variants), as well as inflammatory diseases such as sarcoidosis has slowly led to improved outcomes via disease-specific therapies. (J Am Coll Cardiol 2018;71:1130–48) © 2018 by the American College of Cardiology Foundation.
RRU_A_270495 455..461

Department of Urology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan Background: To evaluate the organ-specific therapeutic effect of paclitaxel and carboplatin (TC) chemotherapy in patients who failed platinum-based chemotherapy and pembrolizumab for metastatic urothelial carcinoma (UC). Patients and Methods: We retrospectively reviewed the data of patients with metastatic UC who had received TC chemotherapy after the failure of platinum-based chemotherapy and pembrolizumab. The RECIST 1.1 criteria were used to assess the objective response to pembrolizumab and TC chemotherapy at tumor sites. Results: We analyzed 8 patients (male, n=5; female, n=3; median age, 65 years old). All patients except one had visceral metastasis. The median overall survival for TC was 10.9 months (95% confidence interval, 1.0-12.7 months), and the objective response rate was 25.0% (partial response [PR]: 2 cases). The metastatic organs were the lymph nodes in 5 cases (number of tumor sites: 8), lung in 4 cases (number of tumor sites: 12), liver in 3 cases (number of tumor sites: 14), bone in 3 cases (number of tumor sites: 12), and primary lesion in 3 cases (number of tumor sites: 3). There were no cases of a complete response or progressive disease in any metastatic organs due to TC chemotherapy. A PR was seen in 2 cases of lymph node metastasis (40.0%), 2 cases of lung metastasis (50.0%), and 2 cases of liver metastasis (66.7%). All 3 cases of bone metastasis showed stable disease, as did all 3 cases of primary lesion. Improvement in the therapeutic effect of TC chemotherapy compared with pembrolizumab was observed in 2 cases (40.0%) of lymph node metastasis, 2 cases (50.0%) of lung metastasis, and 1 case (33.3%) of liver metastasis. Conclusion: Lymph node, lung, and liver metastases may respond to TC chemotherapy, even if exacerbated with pembrolizumab after platinum-based chemotherapy in metastatic UC.
ADVANCES IN THE MANAGEMENT OF DYSLIPIDEMIA

Introduction: Dyslipidemia mainly refers to a disbalance of any form of lipid in the body. Any disbalance of lipid in the body puts the body at a higher risk of coronary and peripheral artery diseases. With the discovery of statins, there has been a huge revolution in the treatment of dyslipidemias. They have shown evidence of reduced levels of LDL with statin leading to a reduction in evidence of CVD. Aim of work: This review aims at discussing the various therapies and new management strategies developed for managing dyslipidemias associated with CVD or Chronic kidney diseases. Methodology: The review is a comprehensive research of PUBMED, Google Scholar, and WHO official page from the year 2010 to 2021 Conclusion: Dyslipidemias tend to increase the patients' risk for major cardiovascular events, which can lead to a higher mortality rate in patients with existing cardiac or kidney disorders. There has been an increased interest in the treatment of dyslipidemias, and various genetic therapies and novel medication, including plant-based proteins, have shown a major breakthrough in the management of dyslipidemias. These novel therapies have proven to be a good adjunct to conventional treatment strategies and hence should be tested more thoroughly.
Routinely Engaging Caregivers to Understand their Experience and Outcome with the PATH Program

Incorporating the caregiver experience is vital for improving care delivery within the patient-provider dyad. The Palliative and Therapeutic Harmonization (PATH) model is a clinical approach that prioritizes the consideration of frailty when making treatment decisions. Using comprehensive assessment tools to appreciate the full scope of frailty, the program provides guidance to frail older adults and their families as they navigate complex medical decisions and consider the appropriateness of proposed interventions. As caregiver involvement is an instrumental component of the program, we set out to understand the caregiver experience of the program using six-month follow-up phone calls that were implemented as a revised standard of care and quality assurance to expand program evaluation efforts. Feedback from 32 randomized caregivers offered insight into their personal experience of the PATH process and reinforced the importance of ongoing dialogue following difficult decision-making and times of transition. Despite varying degrees of satisfaction with PATH program services, all 32 caregivers confirmed that they would recommend PATH to any individual in the position of caring for a frail, elderly family member. Important themes emerged from the survey that will be integrated into future PATH program standards of care and aid in the development of materials and guidelines that can support caregivers as they take on the role of substitute decision-maker. an individualized understanding of the patient’s frailty; (2) ensure shared understanding of the prognostic significance of frailty between clinician and decision maker(s); (3) foster decision making skills within patients, and families/caregivers; and (4) respond to patient health crises as they arise using navigated
Kinematic Analysis and Dimensional Synthesis of Exechon Parallel Kinematic Machine for Large Volume Machining

A parallel kinematic machine (PKM) topology can only give its best performance when its geometrical parameters are optimized. In this paper, dimensional synthesis of a newly developed PKM is presented for the first time. An optimization method is developed with the objective to maximize both workspace volume and global dexterity of the PKM. Results show that the method can effectively identify design parameter changes under different weighted objectives. The PKM with optimized dimensions has a large workspace to footprint ratio and a large well-conditioned workspace, hence justifies its suitability for large volume machining.
Transcriptional analysis of serk1 and serk3 receptor-like kinase mutants

Transcriptional analysis of serk1 and serk3 receptor-like kinase mutants 1 G. Wilma van Esse, Colette A. ten Hove, Francesco Guzzonato, H. Peter van Esse, Mark 2 Boekschoten, Lars Ridder, Jacques Vervoort and Sacco C. de Vries* 3 4 Laboratory of Biochemistry, Wageningen University, Stippeneng 4, 6708 WE Wageningen, the 5 Netherlands 6 1. present address: Department Plant Breeding and Genetics & Department of Plant Developmental 7 Biology, Max Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg 10, 50829 Köln, 8 Germany; Cluster of Excellence in Plant Sciences (CEPLAS), Heinrich-Heine-Universität 9 Düsseldorf, Universitätsstr. 1, 40255 Düsseldorf, Germany 10 2. address: The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, United Kingdom 11 3. address: Nutrition, Metabolism and Genomics group, Wageningen University, Stippeneng 4, 6708 12 WE Wageningen, the Netherlands 13 4. present address: Netherlands eScience Center, Science Park 140 (Matrix I), 1098 XG 14 Amsterdam, the Netherlands 15 * corresponding author 16
Including people in design processes, good but how? Engaging with Inclusive Design Methodology through a digital platform

: www.designingwithpeople. org is a new web tool created to support and inspire designers to design more inclusively. Constructing this web tool revealed a number of insights, and some thoughts for the future of inclusive design are embedded in it. This paper describes these insights as the rationale of the web tool. From influencing policy and business practices to repositioning the subject of design, the concept of Inclusive Design is evolving. What are the next steps? What are the specific questions for inclusive design practice? We explore three more layers of the question, each of which is the title of a subsection:
Developing a pictorial Epworth Sleepiness Scale

Objective The Epworth Sleepiness Scale (ESS) was designed to be self-completed by the patient. However, it may not be understood by all, and unrecognised problems with literacy can impair the process. The ESS has been translated into a pictorial version for use in those with normal or diminished literacy skills. Methods An evaluation of the patients’ ability to self-complete the ESS was undertaken in sleep and non-sleep respiratory clinics. Errors or problems encountered were recorded on a standard questionnaire. With the aid of a medical artist, pictorial representations of the eight ESS questions were developed and the new pictorial ESS was offered to patients alongside the traditional ESS. The two scales were compared for agreement with a kappa statistic, and patients were asked to record a preference for either the written or the pictorial scale. Results Evaluation of the traditional ESS showed that 33.8% (27/80) of ESS-naive patients made errors and 22.5% (18/80) needed help completing the questionnaire. The translated pictorial ESS showed good agreement with the traditional ESS on most questions; median kappa score 0.63, IQR 0.04. Fifty-ﬁve per cent reported a preference for the pictorial scale compared with the standard written ESS. Despite the fact that errors were frequently made on the traditional ESS, 96.8% of participants in the second study reported both scales to be easy to complete. More people (75.6%) reported the pictorial ESS to be very easy, in comparison with (64.6%) the worded ESS questionnaire. Conclusion Errors are common when patients self-complete the traditional written ESS. Pictures with words have been shown to enhance the understanding and translation of medical information, and a pictorial translation of the ESS produces scores comparable with the traditional ESS and may be a suitable alternative for those with normal or diminished literacy.
A Three-dimensional Collagen Lattice Induces Protein Kinase C- (cid:122) Activity: Role in (cid:97) 2 Integrin and Collagenase mRNA Expression

A three-dimensional collagen lattice can provide skin fibroblasts with a cell culture environment that simulates normal dermis. Such a collagen matrix environment regulates interstitial collagenase (type I metalloproteinase [MMP-1], collagenase-1) and collagen receptor (cid:97) 2 subunit mRNA expression in both unstimulated or platelet-derived growth factor–stimu-lated dermal fibroblasts (Xu, J., and R.A.F. Clark. 1996. J. Cell Biol. 132:239–249). Here we report that the collagen gel can signal protein kinase C (PKC)- (cid:122) activation in human dermal fibroblasts. An in vitro kinase assay demonstrated that autophosphorylation of PKC- (cid:122) immunoprecipitates was markedly increased by a collagen matrix. In contrast, no alteration in PKC- (cid:122) protein levels or intracellular location was observed. DNA binding activity of nuclear factor (cid:107) B (NF- (cid:107) B), a downstream regulatory target of PKC- (cid:122) , was also increased by fibroblasts grown in collagen gel. The composition of the NF- (cid:107) B/Rel complexes that contained p50, was not changed. The potential role of PKC- (cid:122) in collagen gel–induced mRNA expression of collagen receptor (cid:97) RNA harvest, cultures were incubated in collagen lattices for 18–24 h. Total RNA was probed with human (cid:97) 2 integrin, MMP-1 and (cid:97) 5 integrin cDNAs. Equal loading was monitored by UV light examination of ethidium bromide–stained gel and confirmed by hybridization of the same blot with [ 32 P]labeled probe for 28S ribosomal RNA. Results are representative of two independent ex- periments.
MANAGEMENT OF POST TRAUMATIC SYMPTOMS WITH PRE- TRAUMATIC VULNERABILITY

Individuals who experience or simply witness traumatic events can develop posttraumatic reactions [1]. It has been shown that after a catastrophic natural disaster, posttraumatic reactions in children may reach epidemic proportions, remain high for a prolonged period, and jeopardize the well being of the child population of the affected region [2]. There is ample evidence that personality structure and experience such as neuroticism or childhood adversity in the period before the traumatic event also influence the risk of developing posttraumatic disorders [3].
Modeling of Complex Multiagent Behavior Using Matrix Representation

— Multi-agent systems are systems that solve complex problems by dividing them into smaller problems and imparting each of them to specialized programs called agents. The reliability of such systems strongly depends on the correctness of agents’ communication and interaction. Unfortunately, the analysis of the whole system is not an easy task as its component parts, in the form of agents, work in an asynchronous way. An additional problem causing the difficulty in this analysis is the fact that each agent is an autonomous being, therefore, having received information from another agent existing in the same environment, it does not have to change its internal condition. In the following paper, matrix representation and equations, describing dynamics of the multiagent system were implemented by using the basic elements of graph theory and theory of compartment modeling. The analysis of equations and examples presented below, confirm the validity of the thesis that the adopted description is sufficient to describe the interactions between agents in the multiagent system.
Behavior of Online Shoppers

In this article we propose a two stage procedure to model demand decisions by customers who are deciding about several dimensions of a product. We then test our procedure by analyzing the behavior of buyers from an Austrian price comparison site. Although here a consumer will typically search for the cheapest price for a given product, reliability and service of the supplier are other important characteristics of the retailer. In our data, consumers follow such a two stage procedure: they select a shortlist of suppliers by looking at their willingness to pay only; among these shortlisted suppliers finally, they trade off reliability and price to a large extent. JEL Classifications L.
NDT_A_255205 3163..3172

1CAMH Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada; 2Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada; 3TransBioTech, Levis, QC G6v 6Z3, Canada Purpose: Greater oxidative signaling is implicated in major depressive disorder; hence, there is considerable interest in developing oral supplements with anti-oxidant properties to prevent or treat mood disorders, such as postpartum depression. L-cysteine is a precursor for glutathione, an important antioxidant in the brain. So, developing L-cysteine as a dietary supplement may be useful, provided oral supplementation substantially raises its concentration in blood plasma yet does not affect its total concentration in breast milk. This study assessed the effect of oral L-cysteine on its concentration in breast milk and blood plasma of breastfeeding mothers. Participants and Methods: Twenty-four health breastfeeding women were randomly assigned to 0, 1.5, or 3 g of oral L-cysteine. Free and total cysteine in breast milk; and free cysteine in plasma were measured. While breast milk is the gold standard, measurement of infant formulas provides indices of nutritional intake considered safe. Therefore, free cysteine was also measured in six different formulas. Results: Total cysteine in breast milk was not affected by oral L-cysteine (Repeated Measures of ANOVA (rANOVA), intervention effect: p=0.75). Free cysteine levels in breast milk did rise (rANOVA, intervention effect: p=0.017), but were within the range of common infant formulas. There was no significant effect of L-cysteine supplementation on free cysteine levels in plasma (rANOVA, intervention effect: p=0.25), although a post hoc analysis found a trend towards greater plasma cysteine 30 minutes after oral supplementation (t(14)=−1.69, p=0.11, 3g versus no-dose). Conclusion: The negligible effect of oral cysteine administration on its total concentration in breast milk was favorable, but the minimal effect on its blood plasma concentration more strongly argues against further development of oral L-cysteine in postpartum, as well as other conditions.
The Effect of Hospital Vertical Integration on Health Care Quality in China

The rapid growth of hospital integration activities in China has made it critical to understand whether integration in health care markets enhanced or damaged quality. The purpose of this study is to analyze the effect of hospital integration on health care quality in Shanghai. Using difference-in-difference analysis, the authors analyze cure rate and length of stay for gastric ulcer patients. The data indicates that hospital integration has positive impact on cure rate 4 years after integration at the 10% significant, but has no significant impact on length of stay. The authors also discuss the implications of these findings and offer directions for future research.
Estimation of the Branch Points of a Branching Diffusion Process

A solution to the problem of estimating the positions and times of the branch points of a Brownian-motion/Yule process, given the positions of all the particles at a particular time, is outlined. A likelihood approach is used, and it is shown that the solution involves maintaining a clear distinction between likelihood and conditional probability if difficulties over mathematical singularities are to be avoided. Several unsolved mathematical problems are encountered, and it is concluded that some simulation studies may be required for a complete solution. Questions of scientific inference which the problem raises are discussed briefly.
The Effect of Irrigation Frequency and Amount on the Growth and Yield of Kale (Brassica Oleracea var. Acephala)

A study was conducted in which Kale (Brassica oleracea var. Acephala) was grown in a Randomized Block Design experiment at the Faculty of Agriculture at Luyengo Campus of the University of Eswatini to compare five different irrigation frequencies (treatments) on the production of kale. The five treatments were: Treatment 0 (T0) the control irrigated daily – applying 5.0 mm, treatment 1 (T1) irrigated after two days, treatment 2 (T2) irrigated after three days, treatment 3 (T3) irrigated after four days and treatment 4 (T4) irrigated after five days. Two litre (2 L) soft drink plastic bottles were used as the irrigation method. The results showed that irrigating kale every two days and applying 14 mm of water was the best option for the Luyengo area compared to applying 5 mm daily. Skipping more than two days between irrigations resulted in significantly lower yields. There were no significant differences in the other measured plant parameters: leaflength, leafwidth, plant height and the number of leaves per plant. The results of these parameters for treatment 1 (T1) were higher of that of the other treatments. Keywords— Kale, yield, Bottle drip, irrigation, frequency, amount.
Transformer asset–management using inﬂuence diagrams with Bayesian statistical models

—Transformer health index (HI) is very useful for representing the overall health of a power transformer, due to the fact that it quantiﬁes equipment condition based on different criteria that are related to the long-term degradation factors that cumulatively lead to the asset’s end-of-life. Moreover, transformer HI is a very powerful tool for managing assets and identifying future investment needs, as well as prioritizing present capital allocations and asset maintenance programs. This paper presents a novel approach to the transformer asset management, which leverages a combination of Bayesian statistical model for transformer HI analysis and inﬂuence diagrams. Inﬂuence dia- grams, as extensions of the Bayesian networks, offer transparent decision-making process under uncertainty, while accounting for transformer HI test reliability and maintenance costs. Asset– management using the proposed model will be demonstrated on a concrete transformer data.
Representations of p-adic groups: a survey

A mine roof support comprises two assemblies one in front of another. The forward assembly carries a mined-material conveyor means, staker means, and a guide or support carrying a mineral winning machine such as a rotary shearer. The rearward assembly serves to support the roof. The support as a whole can be installed in a mine road way or in the stable and can advance itself to extend the roadway or to form a new stable.