Miracle-dz/UniFAR-FTUs huggingface dataset:
Application of biogranules in the anaerobic treatment of distillery effluents

The distillery industry produces large volumes of waste water with a high organic content throughout the year. These effluents must be treated in some manner before being discharged or recycled in the factory. Several treatment options are in use presently, but they all have disadvantages of some nature, such as long retention times, bad odours or the need for large areas of land. Considerable interest has been shown in the application of anaerobic digestion, especially the UASB design (upflow anaerobic sludge blanket), to treat this high strength waste water. Thus, the aim of this study was to investigate the efficiency of an upflow anaerobic sludge blanket (UASB) bioreactor using full-strength distillery effluent. The activity of the bacteria in the biogranules was also evaluated by developing an easy and reliable activity method to estimate the general biogas and methanogenic activity and to calibrate this method using different anaerobic granules from different sources. The influence of high strength distillery effluent on the anaerobic digestion process was investigated using a mesophilic lab-scale UASB bioreactor. During the experimental study, the organic loading rate (OLR) was gradually increased from 2.01 to 30.00 kgCOD.m-3.d-1, and simultaneously, the substrate pH was gradually lowered from 7.0 to 4.7. It was found that at an OLR of 30.00 kgCOD. m-3.d-1,the pH, alkalinity and biogas production stabilised to average values of 7.8, 6 000 mg.r1 and 18.5 I.d-\ respectively. An average COD removal> 90% was found indicating excellent bioreactor stability. The low substrate pH holds considerable implications in terms of operational costs, as neutralisation of the biorector substrate is no longer necessary. The accumulation of fine solids present in the distillery substrate was found at the higher OLR's and resulted in the granular bed increasing with subsequent biomass washout and a lowering in efficiency parameters. However, a possible pre-treatment filtration of these fine solids would eliminate this problem. The success of the upflow anaerobic sludge bed (UASB) process is mainly due to the capability of retaining the active biomass in the reactor. Over the years, several methods have been developed to characterise and quantify sludge activity but each has advantages and disadvantages. There is thus an increasing need for Stellenbosch University http://scholar.sun.ac.za
Field and laboratory studies into the human response to groundborne vibration : exposure-response relationships, perceptual dimensions, and models of annoyance

With proposed increases in both freight and passenger railway in the United Kingdom and the European Union and the building of new high speed lines, there has been an increase in interest in recent years in the human response to vibration in residential environments. As with exposure to environmental noise, exposure to environmental vibration can result in adverse effects such as annoyance and sleep disturbance. However, unlike exposure to environmental noise, well established relationships to evaluate annoyance caused by vibration in residential environments do not exist. In order to predict and control annoyance caused by vibration from environmental sources, a better understanding is needed of how humans perceive vibration and how their perception relates to measureable, quantifiable features of the vibration exposure. In the work presented in this thesis, the human response to vibration is considered on both a community and individual level. The first major aim of this work is to develop statistically robust exposure-response relationships for the human response to railway and construction induced vibration in residential environments. This is achieved via a large scale field survey in which 1431 questionnaires were conducted with residents in their own homes along with extensive vibration measurements at internal and external positions. Analysis of the data collected through this field survey shows that all of the vibration exposure descriptors advocated in national and international standards are equally well correlated with annoyance due to railway induced vibration. Using a grouped regression model, exposure-response relationships describing the proportion of respondents expected to express annoyance above a given threshold are derived for railway and construction induced vibration in terms of a variety of vibration exposure descriptors. The second major aim of this work is to investigate the perception of railway induced vibration on an individual level by investigating the salient dimensions of the perception of whole body vibration. This is achieved via a subjective laboratory test in which paired comparisons of similarity and annoyance are conducted using fourteen measured railway vibration stimuli. Through multidimensional scaling analysis, it is shown that the perception of railway induced vibration is dependent on up to four perceptual dimensions. These dimensions relate to energy in the 16 Hz 1/3 octave band, energy in the 32 Hz 1/3 octave band, the duration of the train passage, and the modulation frequency of the envelope of the signal. These perceptual dimensions are related to single figure Perceived Annoyance Ratings (A) by the following relationship: $A=-0.40+4.57{{\ddot{X}}_{RMS,16Hz}}+3.18{{\ddot{X}}_{RMS,32Hz}}+0.02{{T}_{10dB}}+0.02f{}_{\bmod }$. Finally, the single figure Perceived Annoyance Ratings are related to categorical ratings of annoyance via a logistic regression model.
Variable optical attenuator based on a cutoff modulator with tapered waveguides in polymers

A variable optical attenuator was demonstrated by using a thermooptic cutoff modulator in polymers. It combined horizontally and vertically tapered waveguide structures to improve both the attenuation efficiency and the fiber coupling. The rib height of the waveguides in the input and output region was chosen to achieve minimum fiber coupling loss. For the waveguide in the active region with the electrodes, the rib height was reduced and the width was tapered in order to enhance the attenuation performance by weakening the mode confinement. The two waveguides with different rib heights were connected smoothly by employing a vertical taper, which was realized by utilizing two steps of reactive ion etching with a shadow mask. Then a fiber coupler built in a silicon block was attached directly to the output end of the device. A fraction of the main attenuator output was tapped and fed back to the electrical driver to achieve constant output regardless of variations in input light power and polarization. The measured insertion loss of the attenuator was 2.5 dB at 1550 nm. The dynamic range was more than 20 dB with an electrical power consumption of 160 mW. And the optical response time was faster than 1.5 ms. The effect of polarization on the attenuation was reduced to 0.1 dB by employing a continuous electronic feedback control. The wavelength uniformity was as small as 0.3 dB over the range from 1530 to 1560 nm. Finally, the attenuator was successfully used to regulate channel powers within 0.4 dB in a wavelength division multiplexed transmission system.
Structural Disorder in Layered Hybrid Halide Perovskites: Types of Stacking Faults, Influence on Optical Properties and Their Suppression by Crystallization Engineering

Layered hybrid halide perovskites (LHHPs) are an emerging type of semiconductor with a set of unique optoelectronic properties. However, the solution processing of high-quality LHHPs films with desired optical properties and phase composition is a challenging task, possibly due to the structural disorder in the LHHP phase. Nevertheless, there is still a lack of experimental evidence and understanding of the nature of the structural disorder in LHHPs and its influence on the optical properties of the material. In the current work, using 2D perovskites (C4H9NH3)2(CH3NH3)n−1PbnI3n+1 (further BA2MAn−1PbnI3n+1) with n = 1–4 as a model system, we demonstrate that deviations in LHHPs optical properties and X-ray diffraction occur due to the presence of continuous defects—Stacking Faults (SFs). Upon analyzing the experimental data and modeled XRD patterns of a possible set of stacking faults (SFs) in the BA2MAPb2I7 phase, we uncover the most plausible type of SFs, featured by the thickness variation within one perovskite slab. We also demonstrate the successful suppression of SFs formation by simple addition of BAI excess into BA2MAn−1PbnI3n+1 solutions.
Lactic Acid Bacteria-Fermentable Cereal- and Pseudocereal-Based Beverages

Plant beverages are becoming more popular, and fermented cereal- or pseudocereal-based beverages are increasingly used as alternatives for fermented products made from cow milk. This review aimed to describe the basic components of cereal- or pseudocereal-based beverages and determine the feasibility of fermenting them with lactic acid bacteria (LAB) to obtain products with live and active LAB cells and increased dietary value. The technology used for obtaining cereal- or pseudocereal-based milk substitutes primarily involves the extraction of selected plant material, and the obtained beverages differ in their chemical composition and nutritional value (content of proteins, lipids, and carbohydrates, glycemic index, etc.) due to the chemical diversity of the cereal and pseudocereal raw materials and the operations used for their production. Beverages made from cereals or pseudocereals are an excellent matrix for the growth of LAB, and the lactic acid fermentation not only produces desirable changes in the flavor of fermented beverages and the biological availability of nutrients but also contributes to the formation of functional compounds (e.g., B vitamins).
Effects of Sodium-Glucose Cotransporter 2 on Amputation Events: A Systematic Review and Meta-Analysis of Randomized-Controlled Trials

Introduction: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are increasingly utilized in the treatment of diabetes mellitus as well as therapeutic extra-glycemic effects. However, there are still concerns over complications such as amputation events, given the results from the Canagliflozin Cardiovascular Assessment Study (CANVAS) trial. Hence, we conducted a systematic review and meta-analysis of randomized-controlled trials to investigate the effect of SGLT2 inhibitors on amputation events. Methods: Four electronic databases (PubMed, Embase, Cochrane, and SCOPUS) were searched on November 21, 2020, for articles published from January 1, 2000, up to November 21, 2020, for studies that examined the effect of SGLT2 inhibitors on amputation events. Random-effect pair-wise meta-analysis for hazard ratios and fixed-effect Peto odds ratio meta-analysis were utilized to summarize the studies. Results: A total of 15 randomized-controlled trials were included with a combined cohort of 63,716 patients. We demonstrated that there was no significant difference in amputation events across different types of SGLT2 inhibitors, different baseline populations, and different duration of SGLT2 inhibitor use. Discussion/Conclusions: In this meta-analysis, SGLT2 inhibitors were not associated with a significant difference in amputation events.
MALDI-TOF MS for rapid detection and differentiation between Tet(X)-producers and non-Tet(X)-producing tetracycline-resistant Gram-negative bacteria

ABSTRACT The extensive use of tetracycline antibiotics has led to the widespread presence of tetracycline-resistance genes in Gram-negative bacteria and this poses serious threats to human and animal health. In our previous study, we reported a method for rapid detection of Tet(X)-producers using MALDI-TOF MS. However, there have been multiple machineries involved in tetracycline resistance including efflux pump, and ribosomal protection protein. Our previous demonstrated the limitation in probing the non-Tet(X)-producing tetracycline-resistant strains. In this regard, we further developed a MALDI-TOF MS method to detect and differentiate Tet(X)-producers and non-Tet(X)-producing tetracycline-resistant strains. Test strains were incubated with tigecycline and oxytetracycline in separate tubes for 3 h and then analyzed spectral peaks of tigecycline, oxytetracycline, and their metabolite. Strains were distinguished using MS ratio for [metabolite/(metabolite+ tigecycline or oxytetracycline)]. Four control strains and 319 test strains were analyzed and the sensitivity was 98.90% and specificity was 98.34%. This was consistent with the results obtained from LC-MS/MS analysis. Interestingly, we also found that the reactive oxygen species (ROS) produced by tetracycline-susceptible strains were able to promote the degradation of oxytetracycline. Overall, the MALDITet(X)-plus test represents a rapid and reliable method to detect Tet(X)-producers, non-Tet(X)-producing tetracycline-resistant strains, and tetracycline-susceptible strains.
RNase III, Ribosome Biogenesis and Beyond

The ribosome is the universal catalyst for protein synthesis. Despite extensive studies, the diversity of structures and functions of this ribonucleoprotein is yet to be fully understood. Deciphering the biogenesis of the ribosome in a step-by-step manner revealed that this complexity is achieved through a plethora of effectors involved in the maturation and assembly of ribosomal RNAs and proteins. Conserved from bacteria to eukaryotes, double-stranded specific RNase III enzymes play a large role in the regulation of gene expression and the processing of ribosomal RNAs. In this review, we describe the canonical role of RNase III in the biogenesis of the ribosome comparing conserved and unique features from bacteria to eukaryotes. Furthermore, we report additional roles in ribosome biogenesis re-enforcing the importance of RNase III.
Electroacupuncture for the treatment of frozen shoulder

Abstract Background: Electroacupuncture has been reported to successfully control pain. Currently, no systematic reviews of the effects of electroacupuncture on frozen shoulder patients have been performed. This review aims to provide current evidence on the efficacy of electroacupuncture for the management of pain in frozen shoulder. Methods and analyses: Eleven databases will be searched from their inception: PubMed, AMED, EMBASE, the Cochrane Library, 6 Korean medical databases, and 1 Chinese medical database. Study selection, data extraction, and assessment will be performed independently by 2 researchers. Risk of bias will be assessed using the Cochrane risk of bias assessment tool. Ethics and dissemination: Ethical approvals and patient consent are not required because the meta-analysis will be based on published research. This systematic review will be published in a peer-reviewed journal and disseminated both electronically and in print. The review will be updated to inform and guide health care practice and policy. Trial registration number: PROSPERO 2021 CRD42021247090.
Adaptive Reliability Analysis of Reinforced Concrete Bridges Using Nondestructive Testing

Seismic fragility reflects the ability of a structure to withstand future seismic demands. To obtain an accurate assessment of seismic fragility, it is critical to incorporate information about the current structural properties. This paper describes a probabilistic framework to incorporate information from nondestructive testing (NDT) in the estimates of the seismic fragility of a reinforced concrete (RC) bridge. The proposed framework combines global and local damage detection methods to incorporate information from nondestructive testing (NDT) on the properties of an existing bridge. As an illustration, the proposed probabilistic framework is used to assess the seismic fragility of an example reinforced concrete bridge.
A randomized controlled trial comparing prevention and promotion cognitive strategies in a behavioral weight‐loss intervention

Two approaches may shift attention from short‐term rewards to longer‐term weight‐loss goals: focusing on long‐term consequences of unhealthy choices (prevention) or benefits of healthy choices (promotion). This randomized controlled trial tested the impact of prevention‐ versus promotion‐focused strategies in an internet‐delivered behavioral weight‐loss intervention (iBWL).
Evolution of Thermophilic Microbial Communities from a Deep-Sea Hydrothermal Chimney under Electrolithoautotrophic Conditions with Nitrate

Recent studies have shown the presence of an abiotic electrical current across the walls of deep-sea hydrothermal chimneys, allowing the growth of electroautotrophic microbial communities. To understand the role of the different phylogenetic groups and metabolisms involved, this study focused on electrotrophic enrichment with nitrate as electron acceptor. The biofilm density, community composition, production of organic compounds, and electrical consumption were monitored by FISH confocal microscopy, qPCR, metabarcoding, NMR, and potentiostat measurements. A statistical analysis by PCA showed the correlation between the different parameters (qPCR, organic compounds, and electron acceptors) in three distinct temporal phases. In our conditions, the Archaeoglobales have been shown to play a key role in the development of the community as the first colonizers on the cathode and the first producers of organic compounds, which are then used as an organic source by heterotrophs. Finally, through subcultures of the community, we showed the development of a greater biodiversity over time. This observed phenomenon could explain the biodiversity development in hydrothermal contexts, where energy sources are transient and unstable.
Enhanced performance variable-reluctance transducer for linear-position sensing

The paper presents a development of the linear position transducer of variable-reluctance type, which has enlarged the operating velocity range without a deterioration in accuracy, in comparison with the earlier linear variable-reluctance transducer. An alternative magnetic circuit arrangement has been introduced to allow a substantial increase of excitation frequency with minimal detrimental effect on the output linearity. This, in turn, has enabled velocity-dependent dynamic error to be minimised, through a reduction of the phase shift between processed and actual amplitude envelopes of induced voltages, and by mitigating the undesirable impact of the velocity-dependent component of induced voltage on the output signal. The transducer's accuracy and sensitivity remain independent of the sensing range.
Applications of System Dynamics Models in Chronic Disease Prevention: A Systematic Review

Introduction Chronic disease is a serious health problem worldwide. Given that health care resources are limited, a comprehensive, effective, and affordable way is needed to provide insights to prevent chronic diseases. System dynamics models provide a comprehensive and systematic method that can predict results over time. These models can simulate and predict appropriate prevention measures for chronic diseases to determine the best practice. Methods Two researchers (Y.W., B.H.) independently searched databases (PubMed, Web of Science, Scopus, and Embase) for full-text articles published from January 2000 through February 2021. A PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) 2020–compliant search was carried out to review system dynamics models of chronic disease prevention. A total of 34 articles were included in our study. Results We divided the prevention measures of system dynamics models into 2 main categories: upstream prevention and downstream prevention. Upstream prevention measures include lifestyle (eg, tobacco control, balanced diet, mental health, moderate exercise), obesity prevention, and social factors. Downstream prevention measures include clinical treatment of chronic diseases. Results showed that effective upstream prevention measures could reduce the prevalence of chronic diseases, and downstream prevention measures could reduce the incidence of complications, improve quality of life, prolong life, save medical costs, and reduce mortality. Conclusion To our knowledge, our systematic review is the first to evaluate the application of system dynamics models in preventing chronic diseases. Such models can provide effective simulations. Hence, we can use system dynamics models to design and implement effective prevention measures for people with chronic diseases.
Quercetin attenuates the cardiotoxicity of doxorubicin–cyclophosphamide regimen and potentiates its chemotherapeutic effect against triple‐negative breast cancer

Doxorubicin combined with cyclophosphamide (AC) is the most commonly used regimen for triple‐negative breast cancer (TNBC) chemotherapy; however, its clinical application is severely limited by its serious adverse effect on cardiomyocytes. The cardiotoxicity of AC is mainly the result of oxidative stress caused by the imbalance between reactive oxygen species (ROS) and antioxidants, and it also involves multiple signaling pathways. Quercetin (Que) has been proven to possess strong antioxidant activity, and therefore we investigated whether it had potential protective effect against AC‐induced cardiotoxicity. Meanwhile, we also evaluated its effect on the antitumor activity of AC. Our in vitro studies showed that Que could attenuate AC‐induced cardiotoxicity by inhibiting ROS accumulation and activating ERK1/2 pathway in cardiomyocytes, but interestingly, Que could enhance the antitumor activity of AC by inhibiting ROS accumulation and ERK1/2 pathway in TNBC cells. In addition, our in vivo studies further confirmed that Que could enhance the chemotherapeutic effect of AC against TNBC while it reduced the injury of cardiotoxicity induced by AC. Therefore, Que could be used as a novel agent for the treatment of cardiotoxicity induced by AC regimen in TNBC chemotherapy.
Transmission line coupled active microstrip antennas for phased arrays

An effective transmission line coupling network for spatial power combining and beam scanning purposes is reported. The harmful effect of radiative coupling is eliminated using a modified version of this network for peripheral elements. A technique to control the inter-element phase differences of planar arrays was also developed. Experiments on 1/spl times/4 and 2/spl times/2 oscillator arrays using the proposed coupling network agrees well with the theory.
Neural networks for clustered and longitudinal data using mixed effects models

Although most statistical methods for the analysis of longitudinal data have focused on retrospective models of association, new advances in mobile health data have presented opportunities for predicting future health status by leveraging an individual's behavioral history alongside data from similar patients. Methods that incorporate both individual‐level and sample‐level effects are critical to using these data to its full predictive capacity. Neural networks are powerful tools for prediction, but many assume input observations are independent even when they are clustered or correlated in some way, such as in longitudinal data. Generalized linear mixed models (GLMM) provide a flexible framework for modeling longitudinal data but have poor predictive power particularly when the data are highly nonlinear. We propose a generalized neural network mixed model that replaces the linear fixed effect in a GLMM with the output of a feed‐forward neural network. The model simultaneously accounts for the correlation structure and complex nonlinear relationship between input variables and outcomes, and it utilizes the predictive power of neural networks. We apply this approach to predict depression and anxiety levels of schizophrenic patients using longitudinal data collected from passive smartphone sensor data.