Miracle-dz/UniFAR-FTUs huggingface dataset:
ISG15 and ISGylation in Human Diseases

Type I Interferons (IFNs) induce the expression of >500 genes, which are collectively called ISGs (IFN-stimulated genes). One of the earliest ISGs induced by IFNs is ISG15 (Interferon-Stimulated Gene 15). Free ISG15 protein synthesized from the ISG15 gene is post-translationally conjugated to cellular proteins and is also secreted by cells into the extracellular milieu. ISG15 comprises two ubiquitin-like domains (UBL1 and UBL2), each of which bears a striking similarity to ubiquitin, accounting for its earlier name ubiquitin cross-reactive protein (UCRP). Like ubiquitin, ISG15 harbors a characteristic β-grasp fold in both UBL domains. UBL2 domain has a conserved C-terminal Gly-Gly motif through which cellular proteins are appended via an enzymatic cascade similar to ubiquitylation called ISGylation. ISG15 protein is minimally expressed under physiological conditions. However, its IFN-dependent expression is aberrantly elevated or compromised in various human diseases, including multiple types of cancer, neurodegenerative disorders (Ataxia Telangiectasia and Amyotrophic Lateral Sclerosis), inflammatory diseases (Mendelian Susceptibility to Mycobacterial Disease (MSMD), bacteriopathy and viropathy), and in the lumbar spinal cords of veterans exposed to Traumatic Brain Injury (TBI). ISG15 and ISGylation have both inhibitory and/or stimulatory roles in the etiology and pathogenesis of human diseases. Thus, ISG15 is considered a “double-edged sword” for human diseases in which its expression is elevated. Because of the roles of ISG15 and ISGylation in cancer cell proliferation, migration, and metastasis, conferring anti-cancer drug sensitivity to tumor cells, and its elevated expression in cancer, neurodegenerative disorders, and veterans exposed to TBI, both ISG15 and ISGylation are now considered diagnostic/prognostic biomarkers and therapeutic targets for these ailments. In the current review, we shall cover the exciting journey of ISG15, spanning three decades from the bench to the bedside.
Continuing Medical Education (CME) in time of crisis: How medical societies face challenges and adapt to provide unbiased CME

ABSTRACT Healthcare professionals need to maintain their knowledge and skills to deliver the best possible care to patients. Medical societies play an important role as providers of continuing medical education (CME) and have actively continued this role during the COVID-19 pandemic adapting the delivery of education to virtual meetings and courses. The Biomedical Alliance in Europe CME Experts Committee conducted two surveys to collect information on the delivery of CME, generally, and during the COVID-19 pandemic from the member medical societies. In this article, we will present the most relevant data collected and share some reflections based on this analysis.
The complete mitochondrial genome sequence of the hawkmoth, Dahira obliquifascia (Lepidoptera: Sphingidae) and phylogenetic analysis

Abstract In this study, we sequenced and analyzed the complete mitogenome Dahira obliquifascia to compare mitogenomic structures and reconstruct phylogenetic relationships. The complete mitogenome sequence of D. obliquifascia is circular, 15,939 bp in size and encodes 13 protein-coding genes (PCGs), 2 ribosomal RNA genes (rRNA), 22 transfer RNA genes (tRNA) and a control region (CR). Nucleotide composition is highly biased toward A + T nucleotides (80.3%). All 13 protein-coding genes (PCGs) initiate with the standard start codon of ATN and terminate with the typical stop codon TAA/TAG. Phylogenetic analyses were performed using 13 protein coding genes (PCGs) showed that D. obliquifascia is closely related to Theretra oldenlandiae.
Tree's detection & health's assessment from ultra-high resolution UAV imagery and deep learning

Abstract Detection and classification of crown trees properties and assessment of their health status have raised much interest for the scientists from the forest and environmental sciences due to their essential role in landscape ecology and forestry management. The present study proposes a method based on consumer-based UAVs and deep learning techniques for detecting individual orchard trees and assessing key properties characterising their health status. In the proposed scheme, the Mask R-CNN model is used for detecting and mapping each individual tree morphometrical property such as the height and the crown width. Tree's health assessment is based on the use of vegetation indices such as the Visual Atmospheric Resistance Index (VARI) and Green Leaf Index (GLI), computed from the visible spectrum camera mounted on the UAV platform. The use of the proposed approach is demonstrated at five different orchard tree species, namely plum, apricot, walnut, olive, and almond, located in Romania and Greece, computing a series of statistical metrics. Results returned outstanding ability of the algorithm's performance to map the individual trees and assess their health for four out of the five tree species (plum, walnut, apricot, almond) and satisfactory results for the fifth (olive trees). Overall, the study findings highlighted the promising potential of the proposed methodological framework and its scalable potential for wider applicability as a low-cost, effective solution in mapping individual trees properties and health conditions in the field.
Impact of Strategic Management Practices on the Business Performance of SMEs in Pakistan

Small and Medium Enterprises (SMEs) in Pakistan are playing a significant role in the economic development, and performance of these SMEs is very crucial to the country. Therefore, the aim of current research is to check the significance of strategic management practices in the SMEs operating in the South Punjab of Pakistan. Three variables were created from the existing literature (strategy development,strategy implementation, and strategy evaluation). Convenient sampling has been used to collect primary data through self-administrative questionnaires. By exercising different Inferential Statistical Techniques, this paper has found a significant link between all the strategic management functions and business performance of selected SMEs in the South Punjab of Pakistan.For this purpose, IBM SPSS Statistics software has been applied.This research has recommended that owners as well as management of SMEs should regularly evaluate and take corrective measures on schedule and the progress of various strategies.
Structure and Organization of Regional Renewable Energy Cluster in Vietnam

The regional cluster of renewable energy sources (RES) is an industrial cluster and has the characteristics of the energy industry. Therefore, it needs its own mechanism and structure of formation to ensure integrated development. The paper examines the structure of the regional RES cluster for Vietnam and proposes an apparatus for managing it. Taking into account the experience of other countries, the formation of the structure of the regional RES cluster for the conditions of Vietnam has been substantiated in order to ensure the socio-economic development of the country and its energy system,built and analyzed in accordance with the actual conditions for the use of renewable energy sources in Vietnam and includes five components: profile and non-profile members of the cluster, suppliers, consumers, competitors. A diagram describing the structure of the cluster is illustrated in detail, the roles of the participants are presented. The organizational and management structures of the regional cluster, which correspond to the specific conditions of Vietnam are considered in the paper. The management structure of the Vietnam regional cluster consists of a senior steering committee, facilitator, project manager and working groups. The responsibilities of the participants in the organizational structure are formulated in such a way as to reflect their role in the work of the regional renewable energy cluster. The structure of a regional RES cluster is able to show the relationship between participants inside and outside of the cluster. The organizational structure of the regional cluster and the strategy for its development are the foundations for building a policy in the field of renewable energy sources in the country.
An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector

Aquaculture is the second-fastest-growing sector in the world after informatics and its. Average growth of aquaculture is annually ~8.8% over the last 30 years. Turkey has great potential in terms of fish production and the number of fish farms started to increase rapidly. Fish production in intensive culture conditions has enlarged possible threats of contagious disease outbreaks due to high stocking densities, water quality or environmental gradient, etc., as well as the combination of all these factors together. Depending on animal husbandry situations and organizational conditions, gradation of the aquatic surroundings and outbreaks of bacteriological diseases may well cause production losses around 30-40% in aquaculture facilities. Some fish diseases reported most repeatedly in Turkish aquaculture facilities are Vibriosis, Furunculosis, Streptococcosis, Lactococcosis, Aeromonas septicemia, Yersiniosis, Photobacteriosis and Flavobacteriosis. Antibiotics, disinfectants and chemotherapeutics used for the prevention and treatment of diseases result in residual antibiotics and chemicals in fish products, microorganisms resistant to antibiotics and damages to the aquatic environment and human health. This situation has led researchers to use alternative feed additives in fish diets such as medicinal plant, herbal extracts, phytochemicals, plant secondary metabolites, immunostimulants and probiotics. This review includes research conducted in Turkey between the years 2001 and 2020, and aims to summarize the findings regarding the use of medicinal plant, herbal extracts, phytochemicals, plant secondary metabolites and immunostimulants in fish feed to prevent and treat diseases, improve immunity, increase disease resistance, and reduce stress in fish towards a better management and best aquaculture practice for the sustainability of the growing aquaculture industry in the region and worldwide.
Electronic control system for gasoline automotive engine:state of the art and perspective

As the core research field in the development of high performance and high reliability vehicle engine,the electronic control system is one of the key factors for satisfying the engine performance of power,fuel economy and emissions.The typical structure of the electronic control system of gasoline engine is analyzed firstly.Then,the control technology and theory of gasoline engine electronic control system are reviewed from eight aspects:electronic throttle control,fuel injection control,ignition control,air-fuel ratio control,idle speed control,turbocharging control,knock detection and control and combustion control,where the state of the art of the engine electronic control technology are introduced as a key point.Finally,the prospects for the development of spark ignition engine electronic control system are presented.
On Adaptation in Military Operations: Tinkering and Bottom–Up Perspectives

A biological perspective has much to offer for a better understanding of military operations. Biological evolution and military operations feature perpetual novelty and conditions far from equilibrium featuring dynamics that demand continuous adaptation. The author suggests that comprehending military operations in an evolutionary framework requires a shift from mechanics and engineering to biology and adaptation. Thus the emphasis moves from statics to dynamics, from time–free to time–prone reality, from determinism to probability and chance, and from uni- formity to variation and diversity, with all the consequences.
Research of an On-Line Measurement Method for High-power IGBT Collector Current

The on-line measurement of high-power IGBT collector current is important for the hierarchical control and short-circuit and overcurrent protection of its driver and the sensorless control of the converter. The conventional on-line measurement methods for IGBT collector current are not suitable for engineering measurement due to their large-size, high-cost, low-efficiency sensors, current transformers or dividers, etc. Based on the gate driver, this paper has proposed a current measuring circuit for IGBT collector current. The circuit is used to conduct non-intervention on-line measurement of IGBT collector current by detecting the voltage drop of the IGBT power emitter and the auxiliary emitter terminals. A theoretical analysis verifies the feasibility of this circuit. The circuit adopts an operational amplifier for impedance isolation to prevent the measuring circuit from affecting the dynamic performance of the IGBT. Due to using the scheme for integration first and amplification afterwards, the difficult problem of achieving high accuracy in the transient-state and on-state measurement of the voltage between the terminals of IGBT power emitter and the auxiliary emitter (uEe) has been solved. This is impossible for a conventional detector. On this basis, the adoption of a two-stage operational amplifier can better meet the requirements of high bandwidth measurement under the conditions of a small signal with a large gain. Finally, various experiments have been carried out under the conditions of several typical loads (resistance-inductance load, resistance load and inductance load), different IGBT junction temperatures, soft short-circuits and hard short-circuits for the on-line measurement of IGBT collector current. This is aided by the capacitor voltage which is the integration result of the voltage uEe. The results show that the proposed method of measuring IGBT collector current is feasible and effective.
Ergo-Nutritional Intervention in Basketball: A Systematic Review

Using nutritional supplements is a widespread strategy among basketball players to ensure the appropriate provision of energy and nutrients to avoid certain complaints. Particularly in basketball, there is no consensus on the type, quantity or form of use in which these supplements should be administered. Therefore, the main aim of this systematic review is to highlight the ergo-nutritional aids that may be effective in basketball. A structured search was carried out following the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA®) guidelines in the Medline/PubMed and Web of Science, Cochrane Library, and Scopus databases until 31 December 2021; no year restriction was applied to the search strategy. There were no filters applied to the basketball players’ level, gender, race, or age to increase the power of the analysis. The results of this systematic review have shown that the effective dose of caffeine to enhance anaerobic performance and the feeling of vigorousness and energy ranges from 3 to 6 mg·kg−1, showing more positive effects when is supplemented 60–75 min before exercise in the morning and in test-based task. On the other hand, vitamin E (ranging from 200 to 268 mg), vitamin D (10,000 IU) and EPA (2 g) may have a potential role in recovery and wellness. The primary limitation of this study is the scarcity of studies related to nutritional supplementation in basketball players. However, a major strength is that this is the first systematic review describing what ergo-nutritional aids may be specifically helpful for basketball. Despite the need for future studies, certain nutritional supplements may have promising advantages for basketball (long-term supplementation of nitrates for recovery), whereas others (β-alanine, sodium bicarbonate, and acute nitrate supplementation) might theoretically be regarded as not interesting for basketball, or even not recommended by the World Anti-Doping Agency (WADA) as bovine colostrum.
Assessing the Quality of Long-Term Stored Tissues in Formalin and in Paraffin-Embedded Blocks for Histopathological Analysis

Introduction: Formalin is the most commonly used fixative which enables for long-term storage of specimens and preserves morphologic features allowing the microscopic evaluation for future research analysis. Archival collections of the tissue serve as a reliable tool for diagnostic research purpose. They have an important role in on-going patient care, allows for evaluation of recurrent cases for diagnostic purpose and rare case specimens can also be used as an educational tool as well as for further biomedical research purposes. However, studies assessing quality and their usefulness for such purposes are scanty. Hence, the present study is aimed at evaluating and comparing the tissue changes after long-term storage in formalin as well as in paraffin-embedded blocks. Methodology: Three study groups include specimens stored in formalin for a minimum of 5 years (long-term fixed tissue) and their corresponding paraffin-embedded old tissue blocks along with freshly fixed tissues taken as controls which were subjected to routine histopathological procedures and were assessed for macroscopic and microscopic evaluation. Chi-square test and Z-proportion tests were considered for statistical analysis. Results: Prolonged storage of the tissues in formalin showed variation in color and consistency, difficulty in cutting during grossing with inadequate sectioning characters, loss of tissue integrity and architecture, and inadequate nuclear and cytoplasmic details. Conclusion: On histological analysis, prolonged formalin-stored specimens showed deleterious effects than archival blocks. Hence, it can be proposed that tissues are better preserved in paraffin blocks rather than in formalin for further biomedical research purposes.
A new multi-objective artificial bee colony algorithm based on reference point and opposition

: A new multi-objective artificial bee colony (ABC) algorithm based on reference point and opposition (called ROMOABC) is proposed in this paper. Firstly, the original framework of ABC is modified to improve the efficiency of population renewal and accelerate the convergence rate. On the basis of this framework, two new strategies are proposed. In the scout bee search, opposition-based learning and elite solutions are used to reduce the waste of computing resources. Distribution of solutions is improved by using reference points’ associated external archive. Experiments are conducted on 16 multi-objective benchmark functions including ZDT, DTLZ and WFG multi-objective benchmark functions. The comparison of ROMOABC with five other multi-objective algorithms shows that it has competitive convergence and diversity.
Factors Influencing the Adoption of E-banking Services in Klang Valley

The growth of the Internet and the usage of electronic devices such as computers and mobile phones, have increased e-banking services usage, especially online and mobile bankings. This is a great opportunity to identify and understand which factors would significantly affect the user’s intention to use e-banking services and to give the determining factors of e-banking services in the aspect of the users. This could help banking-related companies to improve their services and products. Quantitative analysis was used in this paper to measure the relationships between e-banking services and user’s intention. In the data collection process, questionnaire was distributed to 390 Malaysians, aged 18 and above, who stay in Klang valley. Statistical Package for Social Science (SPSS) software will be used to analyse the collected data based on Pearson’ correlation coefficient and multiple regression analysis to determine the result.
ORGANIZATIONAL ENVY AND ORGANIZATIONAL CITIZENSHIP BEHAVIOUR: THE MEDIATING ROLE OF LEADER-MEMBER EXCHANGE

This study is founded on the basic thought that disparities in handling by a manager provokes workplace envy, which consistently heralds negative effects on Organizational Citizenship Behaviour (OCB) and extra helping behaviours centred on co-workers. This study investigates the position of workplace envy in the relationship between Organizational Citizenship Behaviour (OCB) and Leader-Member Exchange (LMX) in addition to exploring a likely antithetical correlation between LMX and organizational envy. It thus explores how envy occasioned by poor LMX pressures envious worker’s behaviour or OCB in the workplace and suggests that when workers experience workplace envy, they display decreased motivation to assist others except such activities are stated in their job descriptions. The extra-supportive behaviours displayed by workers are significant for the smooth operations of organizations, so a deeper appreciation of envy as a hindrance to OCB is significantly constructive. The descriptive research design was employed. A sample of 465 respondents was drawn from the 1659 population of the staff of the four selected aviation companies. The Cronbach’s Alpha was utilized to calculate the reliability for the three scales adopted and the results were 0.75, 0.78 and 0.81. To explore the correlations between the different variables of the research, factor analysis, correlation, reliability tests, the means of the variable and regression analysis were utilized. The results of the study sustain the mediating effect of workplace envy on OCB and confirm the negative correlation between Workplace Envy, Organizational Citizenship Behaviour (OCB) and Leader-Member Exchange (LMX). The study recommends the institution of fairness and reasonable compensation schemes in organizations to dispel malicious envy. Also, managers have to be supported to generate helpful and unbiased situations since employees frequently experience envy attributable to gaps in their achievements and remunerations at work as compared with those of their colleagues. Nevertheless, the positive results of envy must be underscored so that envy offers a motivating role in the organisation.
Transcriptomic Analysis of Fish Hosts Responses to Nervous Necrosis Virus

Nervous necrosis virus (NNV) has been responsible for mass mortalities in the aquaculture industry worldwide, with great economic and environmental impact. The present review aims to summarize the current knowledge of gene expression responses to nervous necrosis virus infection in different fish species based on transcriptomic analysis data. Four electronic databases, including PubMed, Web of Science, and SCOPUS were searched, and more than 500 publications on the subject were identified. Following the application of the appropriate testing, a total of 24 articles proved eligible for this review. NNV infection of different host species, in different developmental stages and tissues, presented in the eligible publications, are described in detail, revealing and highlighting genes and pathways that are most affected by the viral infection. Those transcriptome studies of NNV infected fish are oriented in elucidating the roles of genes/biomarkers for functions of special interest, depending on each study’s specific emphasis. This review presents a first attempt to provide an overview of universal host reaction mechanisms to viral infections, which will provide us with new perspectives to overcome NNV infection to build healthier and sustainable aquaculture systems.