Miracle-dz/UniFAR-FTUs huggingface dataset:
Success epochs in a sequence of Bernoulli trials

[3] GRIGELIONIS, B. I. AND SHIRYAEV, A. N. (1966) On Stefan's problem and optimal stopping rules for Markov processes. Theor. Probability Appl. 9, 541-558. [4] McKEAN, H. P. (1965) Appendix: A free boundary problem for the heat equation arising from a problem in mathematical economics. Industrial Management Review 6,2,32-39. [5] SAMUELSON, P. A. (1965) Rational theory of warrant pricing. Industrial Management Review 6, 2, 13-31. [6] TAYLOR, H. M. (1968) Optimal stopping in a Markov process. Ann. Math. Statist. 39, 1333-1344. [7] VAN MOERBEKE, P. (1972) On optimal stopping and free boundary problems. To appear in Acta Math. [8] VAN MOERBEKE, P. (1972) Stochastic optimization problems. (Invited lecture presented at the Conference on Stochastic Differential Equations, Edmonton, Alberta, Canada, July 1972.) To appear in the Rocky Mountains Math. J.
On the computation of measure-valued solutions

A standard paradigm for the existence of solutions in fluid dynamics is based on the construction of sequences of approximate solutions or approximate minimizers. This approach faces serious obstacles, most notably in multi-dimensional problems, where the persistence of oscillations at ever finer scales prevents compactness. Indeed, these oscillations are an indication, consistent with recent theoretical results, of the possible lack of existence/uniqueness of solutions within the standard framework of integrable functions. It is in this context that Young measures – parametrized probability measures which can describe the limits of such oscillatory sequences – offer the more general paradigm of measure-valued solutions for these problems. We present viable numerical algorithms to compute approximate measure-valued solutions, based on the realization of approximate measures as laws of Monte Carlo sampled random fields. We prove convergence of these algorithms to measure-valued solutions for the equations of compressible and incompressible inviscid fluid dynamics, and present a large number of numerical experiments which provide convincing evidence for the viability of the new paradigm. We also discuss the use of these algorithms, and their extensions, in uncertainty quantification and contexts other than fluid dynamics, such as non-convex variational problems in materials science.
Athletes With Attention-Deficit/Hyperactivity Disorder: Position Statement of the American Medical Society for Sports Medicine

Abstract: Athletes of all ages may be affected by medical and mental health issues. Sports medicine physicians should be familiar with common conditions that may affect the well-being of athletes, such as attention-deficit/hyperactivity disorder (ADHD). ADHD behaviors have the potential to affect a person's ability to concentrate. It is likely that social and cognitive therapies combined with pharmacotherapy will be the most effective way to treat ADHD in athletes. Medications used for ADHD, especially stimulant types, are known to improve alertness, reaction time, anaerobic performance, and endurance, which would potentially improve athletic performance. Furthermore, stimulant medications may enable student athletes with ADHD to focus on academic studies for longer periods of time, beyond usual levels of fatigue, important for those who may be exhausted after practices and games. The purported performance enhancement effects and potential adverse effects of stimulant medications have prompted many sports governing bodies to ban prescription stimulants or establish strict rules for their use. Athletes taking physician-prescribed stimulants to treat ADHD need to provide the appropriate documentation for approval before competition or risk punitive measures. Physicians should strive to provide a high quality of care to athletes with ADHD through early diagnosis, appropriate and careful multidisciplinary treatment, and complete and timely documentation to facilitate continued sports participation.
Mechano-Redox Control of Mac-1 De-Adhesion by PDI Promotes Directional Movement Under Flow

Background: Neutrophil migration is critical to the initiation and resolution of inflammation. Macrophage-1 antigen (Mac-1; CD11b/CD18, αMβ2) is a leukocyte integrin essential for firm adhesion to endothelial ICAM-1 (intercellular adhesion molecule 1) and migration of neutrophils in the shear forces of the circulation. PDI (protein disulfide isomerase) has been reported to influence neutrophil adhesion and migration. We aimed to elucidate the molecular mechanism of PDI control of Mac-1 affinity for ICAM-1 during neutrophil migration under fluid shear. Methods: Neutrophils isolated from whole blood were perfused over microfluidic chips coated with ICAM-1. Colocalization of Mac-1 and PDI on neutrophils was visualized by fluorescently labeled antibodies and confocal microscopy. The redox state of Mac-1 disulfide bonds was mapped by differential cysteine alkylation and mass spectrometry. Wild-type or disulfide mutant Mac-1 was expressed recombinantly in Baby Hamster Kidney cells to measure ligand affinity. Mac-1 conformations were measured by conformation-specific antibodies and molecular dynamics simulations. Neutrophils crawling on immobilized ICAM-1 were measured in presence of oxidized or reduced PDI, and the effect of PDI inhibition using isoquercetin on neutrophil crawling on inflamed endothelial cells was examined. Migration indices in the X- and Y-direction were determined and the crawling speed was calculated. Results: PDI colocalized with high-affinity Mac-1 at the trailing edge of stimulated neutrophils when crawling on ICAM-1 under fluid shear. PDI cleaved 2 allosteric disulfide bonds, C169-C176 and C224-C264, in the βI domain of the β2 subunit, and cleavage of the C224-C264 disulfide bond selectively controls Mac-1 disengagement from ICAM-1 under fluid shear. Molecular dynamics simulations and conformation-specific antibodies reveal that cleavage of the C224-C264 bond induces conformational change and mechanical stress in the βI domain. This allosterically alters the exposure of an αI domain epitope associated with a shift of Mac-1 to a lower-affinity state. These molecular events promote neutrophil motility in the direction of flow at high shear stress. Inhibition of PDI by isoquercetin reduces neutrophil migration in the direction of flow on endothelial cells during inflammation. Conclusions: Shear-dependent PDI cleavage of the neutrophil Mac-1 C224-C264 disulfide bond triggers Mac-1 de-adherence from ICAM-1 at the trailing edge of the cell and enables directional movement of neutrophils during inflammation.
Interior proximal bundle algorithm with variable metric for nonsmooth convex symmetric cone programming

This paper is devoted to the study of a bundle proximal-type algorithm for solving the problem of minimizing a nonsmooth closed proper convex function subject to symmetric cone constraints, which include the positive orthant in , the second-order cone, and the cone of positive semidefinite symmetric matrices. On the one hand, the algorithm extends the proximal algorithm with variable metric described by Alvarez et al. to our setting. We show that the sequence generated by the proposed algorithm belongs to the interior of the feasible set by an appropriate choice of a regularization parameter. Also, it is proven that each limit point of the sequence generated by the algorithm solves the problem. On the other hand, we provide a natural extension of bundle methods for nonsmooth symmetric cone programs. We implement and test numerically our bundle algorithm with some instances of Euclidean Jordan algebras.
Polycaprolactone Electrospun Nanofiber Membrane with Skin Graft Containing Collagen and Bandage Containing MgO Nanoparticles for Wound Healing Applications

The objective of this study was to create a nanofiber-based skin graft with an antimicrobial bandage that could accelerate the healing of an open wound while minimizing infection. To this end, we prepared a bi-layer construct where the top layer acts as bandage, and the bottom layer acts as a dermal equivalent graft. A collagen (CG) gel was combined without and with an electrospun polycaprolactone (PCL) membrane to prepare CG and CG-PCL dermal equivalent constructs. The antibacterial properties of PCL with and without an antibacterial agent (MgO nanoparticles) against Staphylococcus aureus (ATCC 6538) was also examined. Human dermal fibroblasts were cultured in each construct to make the dermal equivalent grafts. After culturing, keratinocytes were plated on top of the tissues to allow growth of an epidermis. Rheological and durability tests were conducted on in vitro dermal and skin equivalent cultures, and we found that PCL significantly affects CG-PCL graft biological and mechanical strength (rheology and durability). PCL presence in the dermal equivalent allowed sufficient tension generation to activate fibroblasts and myofibroblasts in the presence of transforming growth factor-beta. During culture of the skin equivalents, optical coherence tomography (OCT) showed layers corresponding to dermal and epidermal compartments in the presence or absence of PCL; this was confirmed after fixed specimens were histologically sectioned and stained. MgO added to PCL showed antibacterial activity against S. aureus. In vivo animal studies using a rat skin model showed that a polycaprolactone nanofiber bandage containing a type I collagen skin graft has potential for wound healing applications.
Integrated optical sensor using hybrid plasmonics for lab on chip applications

We propose a novel, compact plasmonic sensing structure based on a metal–insulator–metal waveguide hybridly-coupled to a rectangular side cavity. The structure has been numerically investigated using the finite-difference time-domain method. Transmission spectra obtained from numerical simulations are used to analyze the sensing characteristics of the structure. The effects of the geometrical parameters on transmission and sensing of the structure are studied. With optimum design, sensitivity can reach as high as 1500 nm per refractive-index unit around the resonance wavelength of 1550 nm with a cavity area of 1 μm2. The proposed structure can potentially be applied in on-chip pressure and gas micro-sensors.
Clinical Implications and Risk Factors for Erectile Dysfunction in Kidney Transplant: A Single-Center Assessment

Background: Erectile dysfunction (ED) affects the great majority of people undergoing dialysis and also the majority of patients undergoing kidney transplantation. In this study, we investigated the degree of erectile dysfunction (ED), as well as its prevalence, contributory variables, and overall impact after renal transplant. Methods: Adult male kidney transplant patients were the subject of an observational, non-interventional study that was conducted at a single center. Age, time and type of dialysis before transplantation, comorbidities, factors associated with cardiovascular risk, data on sexual history, physical examination, and laboratory results were among the clinical data we examined. In addition to gathering clinical and demographic characteristics, the International Index of Erectile Function (IIEF) questionnaire was used to evaluate sexual function. Results: A total of 170 renal transplanted patients between 20 and 70 years old (mean age: 45.40±11.5) were included in this study. All of the patients had immunosuppressive treatment with a calcineurin inhibitor (cyclosporine or tacrolimus) and had a normal glomerular filtration rate (GFR). The prevalence of sexual dysfunction increased with age (42.6% of patients under 40, 47.4% of patients in the 40-60 age group, and 78.9% of patients over 60). Mild, moderate, and severe ED was noted in 33.5%, 20.6%, and 10.6% of cases, respectively, and 51 (30%) patients reported having a normal sexual function. While calcium channel blockers (122 cases) were the most commonly used antihypertensive medication and chronic glomerulosclerosis (55.3%) was the most common cause of chronic kidney disease (CKD) before transplantation, none of these variables appear to have affected the severity of erectile dysfunction. The only medications associated with sexual dysfunction were alpha-blockers and aspirin (75 mg) (p=0.026 and p=0.013, respectively). Conclusions: Although kidney transplantation has positive impacts on the quality of life, erectile dysfunction is a frequent condition among patients with renal transplants, and it has an increased frequency with age. In our study, it has been observed that only a small percentage of the research group had a normal sexual function, although most of the patients were young, and that alpha-blockers and aspirin (75 mg) are associated with erectile dysfunction.
SIMPLY CONNECTED GROUPS, THE HYPERALGEBRA, AND VERMA'S CONJECTURE.

A finite-dimensional representation of a connected affine algebraic group is determined by the behavior of the operators coming from the hyperalgebra of the group. In order to get a complete picture of the representation theory of the group in terms of that of the hyperalgebra, one questions whether every finite-dimensional representation of the hyperalgebra comes from a representation of the group (see [1] for instance). In this paper, we show the following two things: 1. A simply connected group in positive characteristic is the inductive limit of its infinitesimal neighborhoods of the identity. 2. Each finite-dimensional representation of the hyperalgebra of a simply connected group comes from a representation of the group. Each of these two properties characterizes the simply connected groups. The proof of the second fact completes an aspect of the work begun in the paper [1] on the hyperalgebra. In characteristic zero, a group is called simply connected if it cannot be covered by another group by a map with finite, non-trivial kernel. In line with this definition, Takeuchi in [3] defines a group in characteristic p to be simply connected if it has no non-trivial etale coverings. An interpretation of Theorem 1.9 of [3] leads to condition 1 above for simple connectedness in terms of infinitesimal neighborhoods. This condition in turn yields Verma's conjecture: finite-dimensional representations of the hyperalgebra of a simply connected group are rational. Let G be an affine k-group with coordinate ring A over a field k of characteristic p. Let M be the kernel of the augmentation map of A, and let
300 nights of science with IGRINS at McDonald Observatory

The Immersion Grating Infrared Spectrometer (IGRINS) is a revolutionary instrument that exploits broad spectral coverage at high-resolution in the near-infrared. IGRINS employs a silicon immersion grating as the primary disperser, and volume-phase holographic gratings cross-disperse the H and K bands onto Teledyne Hawaii-2RG arrays. The use of an immersion grating facilitates a compact cryostat while providing simultaneous wavelength coverage from 1.45 - 2.5 μm. There are no cryogenic mechanisms in IGRINS and its high-throughput design maximizes sensitivity. IGRINS on the 2.7 meter Harlan J. Smith Telescope at McDonald Observatory is nearly as sensitive as CRIRES at the 8 meter Very Large Telescope. However, IGRINS at R≈45,000 has more than 30 times the spectral grasp of CRIRES* in a single exposure. Here we summarize the performance of IGRINS from the first 300 nights of science since commissioning in summer 2014. IGRINS observers have targeted solar system objects like Pluto and Ceres, comets, nearby young stars, star forming regions like Taurus and Ophiuchus, the interstellar medium, photo dissociation regions, the Galactic Center, planetary nebulae, galaxy cores and super novae. The rich near-infrared spectra of these objects motivate unique science cases, and provide information on instrument performance. There are more than ten submitted IGRINS papers and dozens more in preparation. With IGRINS on a 2.7m telescope we realize signal-to-noise ratios greater than 100 for K=10.3 magnitude sources in one hour of exposure time. Although IGRINS is Cassegrain mounted, instrument flexure is sub-pixel thanks to the compact design. Detector characteristics and stability have been tested regularly, allowing us to adjust the instrument operation and improve science quality. A wide variety of science programs motivate new tools for analyzing high-resolution spectra including multiplexed spectral extraction, atmospheric model fitting, rotation and radial velocity, unique line identification, and circumstellar disk modeling. Here we discuss details of instrument performance, summarize early science results, and show the characteristics of IGRINS as a versatile near-infrared spectrograph and forerunner of future silicon immersion grating spectrographs like iSHELL2 and GMTNIRS.3
Outcomes After Concomitant Hip Arthroscopy and Periacetabular Osteotomy: A Systematic Review

Background: Despite several studies’ reports on outcomes of concomitant hip arthroscopy and periacetabular osteotomy (PAO), there is a paucity of aggregate data in the literature. Purpose: To evaluate outcomes and survivorship after concomitant hip arthroscopy and PAO. Study Design: Systematic review; Level of evidence, 4. Methods: The PubMed, Cochrane, and Scopus databases were searched in April 2022 using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The following keywords were used: (hip OR femoroacetabular impingement) AND (arthroscopy OR arthroscopic) AND (periacetabular osteotomy or rotational osteotomy) AND (outcomes OR follow-up). Of 270 articles initially identified, 10 studies were ultimately included. The following information was recorded for each study if available: publication information; study design; study period; patient characteristics; follow-up time; indications for hip arthroscopy; patient-reported outcomes (PROs); rates of secondary hip preservation surgeries; and rates of conversion to total hip arthroplasty (THA). Survivorship was defined as nonconversion to THA. Results: The study periods for the 10 included articles ranged from 2001 to 2018. Three studies were level 3 evidence, and 7 studies were level 4 evidence. This review included 553 hips with a mean follow-up of 1 to 12.8 years. All 10 studies listed dysplasia as an indication for surgery. Of 9 studies that reported PRO scores, 7 reported significant improvement after surgery. Studies with a <5-year follow-up reported conversion to THA rates of 0% to 3.4% and overall secondary surgery rates of 0% to 10.3%. Similarly, studies with >5-year follow-up reported conversion to THA rates of 0% to 3% and overall secondary surgery rates of 0% to 10%. Conclusion: Patients who underwent concomitant hip arthroscopy and PAO reported favorable outcomes, with 7 of the 9 studies that provided PRO scores indicating significant preoperative to postoperative improvement.
A Numerical Study of Drop Motion in Poiseuille Flow

The cross-stream migration of a deformable drop in two-dimensional Poiseuille flow at finite Reynolds numbers is studied numerically. In the limit of a small Reynolds number (<1), the motion of the drop depends strongly on the ratio of the viscosity of the drop fluid to the viscosity of the suspending fluid. For a viscosity ratio 0.125, the drop moves toward the centre of the channe while for the ratio 1.0, it moves away from the centre until halted by wall repulsion. The rate of migration increases * $ D ow nl oa de d fr om ja m e. iu t.a c. ir at 1 9: 53 IR S T o n S at ur da y O ct ob er 2 6t h 20 19
Projective Imagination: Vilém Flussers’s Concept of the Technical Image

The article discusses the technical image, a central concept in Vilém Flusser’s later main work Into the Universe of Technical Images (1985a). After identifying its various dimensions, the analysis frames the concept as an amalgamation of disciplines, theories, and artistic practices the cultural philosopher Flusser explored during the 1960s and especially the 1970s. In particular, the field of information aesthetics developed by Max Bense and Abraham A. Moles, among others, as well as artistic video practices in France and the United States played an important role in both Flusser’s biography and the formation of his technical image concept. At the same time, in Flusser’s cultural philosophy the technical image is the condition and result of a new kind of human imagination, which in this paper is specified as ‘projective imagination’.
Electrical Impedance Tomographic Mapping of Hypoventilated Lung Areas in Intubated Patients With COVID-19

Since the first description of ARDS, bilateral alveolar infiltrates on chest radiography have been recognized as characteristic of this syndrome, combined with hypoxemia and low respiratory system compliance (CRS). 1 Due to its simplicity, chest radiography is still a pillar of the actual ARDS definition. However, only the advance to chest computed tomography (CT) allowed clinicians to precisely identify the site of lung disease, revealing the heterogeneous distribution of lung injury in patients with ARDS. As with previous ARDS descriptions, CT studies reported a variety of areas with pulmonary involvement in subjects with COVID-19, such as multilobar groundglass opacities and consolidation located mainly in the gravity-dependent regions. The use of a chest CT to phenotype ARDS as a focal or non-focal disease is also advocated to allow personalized mechanical ventilation. However, the use of CT is limited by the ionizing radiation and the need for patient transfer. In this scenario, electrical impedance tomography (EIT) has been used at the bedside to monitor pulmonary function in real time during mechanical ventilation. In this report, we aimed to describe the distribution pattern of hypoventilated regions (ie, areas with deteriorated lung function) in patients with COVID-19–related ARDS under invasive mechanical ventilation with the use of EIT. In addition, we assessed the relationship between the distribution pattern of hypoventilated regions with CRS and gas exchange (PaO2/FIO2).
Dating the Pleistocene hominin ichnosites on South Africa’s Cape south coast

Abstract Seven hominin ichnosites in aeolianites on the Cape south coast of South Africa have been dated using Optically Stimulated Luminescence, yielding age estimates from Marine Isotope 6 through Marine Isotope Stage 4. All rock outcrops containing these sites are situated on the modern coastline. The new ages are consistent with geomorphological expectations, and with other numerical dating results from the wider southern Cape coastline. Seen in a global ichnological context, the cluster of South African sites (including two previously dated sites) contains nine of the twenty-three sites older than 70 ka from which hominin tracks have been reported. With a single exception they are also the only sites older than 40 ka that have been attributed to Homo sapiens, and include the oldest tracks (153 ± 10 ka) thus far attributed to our species. The South African coastline contains an archaeological and palaeoanthropological record of global significance, to which the hominin ichnological record, preserved on aeolianite palaeosurfaces and now chronologically constrained, can make a substantial contribution.
The Conscious Universe Part And Whole In Modern Physical Theory

Thank you for reading the conscious universe part and whole in modern physical theory. As you may know, people have look numerous times for their chosen books like this the conscious universe part and whole in modern physical theory, but end up in harmful downloads. Rather than enjoying a good book with a cup of coffee in the afternoon, instead they are facing with some infectious virus inside their laptop.