Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular basis of ectodermal dysplasia: a comprehensive review of the literature

Ectodermal dysplasia (ED) syndrome is a rare genetic disease that involves a heterogeneous group of hereditary disorders that occur as a result of mutations in genes that code for development of fetal ectoderm and lead to numerous disorders. Defects in the development of the ectoderm cause symptoms in tissues derived from the ectoderm layer, such as skin, nails, hair, and teeth. Because many pathways are involved in the development of the ectoderm, there are mutations in many genes that cause ED. Owing to the heterogeneity of ED, there are different types of the disease that have different symptoms. These symptoms include sparse hair, abnormal or missing teeth, nail dystrophy, lack of sweating owing to the absence of sweat glands, and cancer. In this review, in addition to discussing the role and pathway of each of the genes involved in ED, the incidence of cancer in these patients, diagnostic methods and differentiation from other similar diseases, and the treatments currently being performed for ED are discussed.
Jojoba oil-based microemulsion for transdermal drug delivery

Background and purpose: Microemulsions are gaining an increased interest in transdermal drug delivery. Microemulsions are stable, easy to prepare, and provide high solubilizing capacity for various drugs. The aim of this work was to prepare microemulsions from jojoba oil for transdermal delivery of ketorolac and lidocaine HCl with improved permeation. Experimental approach: Microemulsions based on jojoba oil as the oil phase were formulated for transdermal delivery of lidocaine HCl and ketorolac. Brij 97 was selected as surfactant and hexanol as cosurfactant. Pseudoternary phase diagrams were constructed. Selected microemulsion formulations were characterized for their physical properties and in vitro drug permeation. Findings/Results: Water-in-oil microemulsions were obtained with droplet sizes not more than 220 nm. The viscosity of the microemulsions was linked to the viscosity of the surfactant used. Improved drug permeation rates were observed for both model drugs. The significant increase in permeation rate in presence of hexanol was due to its impact on skin integrity as indicated by the histopathological study. Drug permeation enhancements were caused by the surfactant, the cosurfactant used, jojoba oil itself, and the microemulsion formulation. Higher surfactant content showed lower lag times and better flux. Conclusion and implications: Jojoba oil microemulsions are considered promising vehicles for transdermal delivery of ketorolac and lidocaine HCl with improved drug permeation. Jojoba oil-based microemulsion would present a safe and effective means for delivering drugs through the skin.
Brain Image Analysis, Arterial Spin Labeling Perfusion Images and Joint EEG-fMRI Neurofeedback

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Brain Image Analysis, Arterial Spin Labeling Perfusion Images and Joint EEG-fMRI Neurofeedback Pierre Maurel
Strategic Orientation and Business Performance in West Sumatera

Competition during this period of disruption was getting higher and spread to the Micro, Small, and Medium Enterprises (MSMEs) level. With good and sustainable business performance growth, this provides an opportunity for MSMEs to become large businesses or even go public. Businesses must be managed strategically and systematically to put the benefits of good business performance. Business performance needs to be improved due to rapid environmental changes, market mechanisms that are increasingly open, competitive, and market domination. One measure of strategic orientation and business performance achievement can be seen from the overall production and marketing activities originating from MSMEs. The purpose of this study was to analyze: (1) The effect of entrepreneurial orientation on the business performance of Micro, Small, and Medium Enterprises in West Sumatra, and (2) The effect of market orientation on the business performance of Micro, Small, and Medium Enterprises in West Sumatra. The object of this research is focused on MSMEs in West Sumatra. The population of this study is all MSMEs in the cities of Padang, Bukittinggi, and Payakumbuh. The research sample consisted of 100 MSMEs, using proportional cluster random sampling. This type of research is causative. The analysis tool is a Structural Equation Model (SEM) using the Smart PLS version 2.0 application.
Sekundární prevence ischemické choroby srdeční a chorob periferních tepen kombinací antiagregační a antikoagulační léčby. Odborné stanovisko České kardiologické společnosti, České internistické společnosti ČLS J.E. Purkyně a České angiologické společnosti ČLS J.E. Purkyně k výsledkům studie COMPASS

Ischemická choroba srdeční Kardiovaskulární onemocnění (KVO) stojí stále na prvním místě jako nejvýznamnější příčina úmrtí. V období mezi lety 1985–2012 došlo v české populaci k významnému snížení úmrtnosti na ischemickou chorobu srdeční (ICHS) o více než 50 % u mužů a o 43 % u žen. KV mortalita klesla u mužů i u žen v průměru o 52 % [1]. Na snížení KV úmrtnosti se podílela jak léčba akutních stavů (především invazivní léčba akutního infarktu myokardu), tak i preventivní opatření, nefarmakologická i farmakologická. Primární prevence může snížit incidenci ICHS, tj. výskyt nových onemocnění ICHS včetně náhlých koronárních úmrtí, a tím redukovat i prevalenci choroby v populaci. Úkolem sekundární prevence je zamezit recidivě koronární příhody, zabránit progresi choroby, ev. navodit regresi aterosklerózy, a tak snižovat riziko ICHS i ostatních KV onemocnění [2]. Výsledky studií EURO ASPIRE I–V, které proběhly v letech 1995–2017 v řadě evropských zemí včetně ČR, však nejsou uspokojivé. Velký potenciál je v modifikaci životního stylu i v nedostatečné léčbě hypertenze a dyslipidemie (DLP), a to včetně nedostatečné adherence pacientů k léčbě [3]. Pacient s ICHS je prioritou sekundární prevence KV onemocnění. Odvykání kouření u pacientů kuřáků je jednou z nejdůležitějších úprav životního stylu, neboť po zanechání kouření se nejvíce snižuje celkové KV riziko. Fyzická aktivita nemusí mít tréninkový charakter, ale měla by být aerobní a hlavně pravidelná; 6 000 kroků denně je jednoduchý a účinný pohyb. Hlavní zásadou diety v rámci sekundární prevence ICHS je záměna nasycených mastných kyselin nenasycenými, dostatek ovoce, zeleniny, luštěnin a ořechů. Nepatří do ní nadměrné solení ani konzumace alkoholu; dle posledního doporučení lze tolerovat 1 alkoholový nápoj za den u žen a maximálně 2 alkoholové nápoje za den u muže (1 alkoholový nápoj je přibližně 1/3 l piva nebo 1 dcl vína nebo 5 cl destilátu). Doporučený body mass index (BMI) v rozmezí 20–25 kg/m2 je v asociaci s nejnižší KV úmrtností. Farmakoterapie v sekundární prevenci zahrnuje několik oblastí: antitrombotickou léčbu (antiagregancia anebo antikoagulancia), hypolipidemickou léčbu, beta blokátory a inhibitory ACE. Dlouhodobá antitrombotická léčba spočívá především v podávání kyseliny acetylsalicylové (ASA, aspirin) v nízkých dávkách (75–100 mg). Další možnosti jsou stručně shrnuty v tab. 1 a v doporučených postupech Evropské kardiologické společnosti (European Society of Cardiology – ESC) [4].
ISSUES AND CHALLENGES IN SPECIAL EDUCATION: A QUALITATIVE ANALYSIS FROM TEACHER’S PERSPECTIVE

The general purpose of this study is to determine the issues and challenges of special education (SPED) teachers in teaching children with learning disabilities in the City Division of Ilagan Isabela, Philippines. The 15 SPED teachers were served as the respondents of this study using purposive sampling technique. Qualitative Research Method (QRM) was utilized to determine the issues and challenges of the teachers. Thematic analysis was employed to interpret the data. The analyses on the sharing of the key informants regarding their collective description of their challenges as SPED teacher led to the emergence of five distinct themes that include, choosing appropriate strategy and motivation; identifying individual needs; challenging but fulfilling; acceptance and patience; and respect one’s right. Most teachers teaching children with learning disabilities did not receive any special needs education training from the school, they feel that they are not qualified to teach the children with learning disability. Moreover, teachers assigned in SPED classes lack of strategies in dealing with learners with disabilities. This study revealed that the classrooms for children with learning disabilities in Division of Ilagan at large have poor learning environment to support the SPED such as lack of budget, curriculum guide, Instructional Materials (IMs) and even school facilities. It could be concluded that placement of learners with special needs in an inclusive classroom with ordinary learners is not enough with no proper support. Learners with disability did not receive all the necessary support and services for accessing the curriculum facilities; and stakeholders’ supports is very minimal to support the needs of the students enrolled in SPED classes. On the other hand, issues and problems were solved technically to sustain the positive working environment among school heads, teachers and stakeholders. The Department of Education Training and Development in collaboration with regional in service officers should organize continuous professional development opportunities on inclusion strategies of learners with SPED needs. The implementers of the SPED programs shall strictly adhere to the policies, and the strong support of the stakeholders shall be encouraged by formulating active organization spearheaded by the school head.
To Study the Effects of the PNF Stretching and Stabilization Exercises on the Improvement of Pain and Spastic Shoulder in Hemiplegic Patients: A Comparative Study

Stroke is the leading cause of adult disability and inpatient rehabilitation admissions. The WHO definition of stroke is rapidly developing clinical signs of focal (global) disturbance of cerebral function, with symptoms lasting 24hours or longer or leading to death, with no apparent cause other than of vascular origin: it includes patients presenting clinical signs and symptoms suggestive of subarachnoid haemorrhage, intracerebral haemorrhage or cerebral ischemic necrosis. An estimated 70% of the patients who survive a stroke are unable to use their limbs (Upper Limb/Lower Limb) independently during the first three to four weeks post stroke. Patients who have suffered a stroke experience loss, uncertainty, and social isolation, as stroke represents a sudden, overwhelming, and fundamental change for the survivor. Personal control over progressoptimism, and fears of dependency, as well as markers of independence and interaction with therapists, were identified as important factors influencing recovery. Effective rehabilitation strategies are of utmost concern to different parts of the health care system. Their value resides both in giving people affected by stroke the best possible opportunity for their recovery as individuals and in offering health organizations the best use of limited finances and resources. The objective of the study was to compare the effectiveness of PNF(Proprioceptive Neuromuscular Fascilitation) stretching and stabilizations exercises techniques in the improvement of pain and spastic shoulder.30 post stroke patients (affected for a period of more than 6months), 40-60 years of age were randomly assigned to PNF stretching and stabilization exercises were collected on Day 0, DAY 90. Paired t-test were used for statistical interventions. Assessment of Visual Analogue Scale (VAS) and Modified Ashworth Scale were performed. Analysis of scores showed significant improvement (p<0.02) overtime within the groups and inter group analysis showed statistical significance. The study concluded that PNF Stretching technique is better than Stabilization techniques in improving pain and spastic shoulder in chronic stroke patients.
The Effect of Extra Educational Elements on the Confidence of Undergraduate Dental Students Learning to Administer Local Anaesthesia

Local anaesthesia is taught early in the practical part of dental programs. However, dental students express uncertainty and concern before their practical training in local anaesthesia. The aim of this study was to evaluate how extra educational elements in the teaching of local anaesthesia affect students’ confidence using local anaesthesia. The students were divided into three groups (A, B and C). Group A received the same education that was used the previous year (i.e., four hours of theoretical lectures followed by four hours of practical exercises performed on a fellow student). Group B did their practical training on fellow students in groups of three, with each student taking turns performing, receiving and observing the procedure. Group C received training using an anatomically correct model before their practical training on a fellow student. After each training step, the students completed a questionnaire about their confidence administering local anaesthesia. The students experienced a significant increase in confidence after each educational step. Combining theory and practical instruction, including the use of anatomically correct models and peer instruction, improved students’ confidence in administering local anaesthesia. The greatest increase in confidence was in the students placed in groups of three where each student performed, received and observed the procedure.
Therapeutic Applications of Nanorobots- Respirocytes and Microbivores

Nano medicine offers the prospect of powerful new tool for monitoring, repair, construction and treatment of human diseases and the improvement of human biological system using molecular nanotechnology. Changes in human behavior and life style over the last century have resulted in a dramatic increase in the diseases world-wide. Among the numerous conditions which can do harm to the human, the most fundamental problem may be due to lack of perfusion of oxygen to the tissue and blood borne pathogens. Insufficient oxygenation can lead to anemia, heart attack and sudden loss of blood supply. To overcome this, one of novel therapeutic technological concept in nanomedicine includes the application of respirocytes and microbivores to treat such conditions in humans.
Drying characteristics and quality of bananas under infrared radiation heating.

Hot air (HA) drying of banana has low drying efficiency and results in undesirable product quality. The objectives of this research were to investigate the feasibility of infrared (IR) heating to improve banana drying rate, evaluate quality of the dried product, and establish models for predicting drying characteristics. Banana slices of 5 mm and 8 mm thickness were dried with IR and HA at product temperatures of 60C, 70C and 80C. Banana drying characteristics and changes in residual polyphenol oxidase (PPO), Hydroxymethylfurfural (HMF), color, moisture content (MC) and water activity during the treatments were investigated. Results showed that significant moisture reduction and higher drying rates were achieved with IR drying compared to HA drying in the early stage. The drying data could be fitted to the Page model for accurate prediction of MC change for IR and HA drying with mean R2 of 0.983. It was noted that enzyme inactivation occurred more quickly with IR than with HA drying. A unique response of PPO under IR and HA drying was revealed. IR heating of banana inactivated PPO within the first 20 min of drying at 60C, 70C and 80C, while PPO was first activated before inactivation at 60C and 70C drying with HA. The highest HMF content occurred in banana slices with 5 mm thickness dried with IR at a product temperature of 80C. It is therefore recommendable to dry banana with IR at product temperature of 70C or below to preserve the product quality. These findings are new and provide more insight in the application of IR heating for drying banana for improved drying rate and product quality.
Antecedents of Consumers’ Purchase Intention towards Organic Food: Integration of Theory of Planned Behavior and Protection Motivation Theory

Before consequences of climate change continue to intensify and increasingly affect the entire planet, immediate action must be taken. For instance, adopt the pro-environmental behaviors such as purchase of organic food to minimize the harmful human-caused impacts to the environment. This paper aims to determine the factors that influence the purchase intention of organic food in Malaysia by applying the theory of planned behavior and the protection motivation theory. A total of 300 questionnaires were collected and PLS-SEM was employed to test the structural relationships. Consequences of climate change and health threats were not the primary concerns among Malaysians when deciding whether to purchase organic food. Results show that perceived vulnerability, response efficacy, self-efficacy, subjective norm, and attitude affect purchase intention towards organic food. Consumers were more likely to have positive attitude towards organic food when they have adequate information on vulnerability of a threat and its consequences. The findings provide insights on the antecedents and outcomes of purchase intention towards organic food particularly in Malaysia. Although predictive power of perceived factors such as perceived rewards and perceived efficacy have been extensively researched in the past, there are limited studies that integrate both theories that simultaneously investigate antecedents of consumers’ purchase intention towards organic food.
Decision support for the intermodal terminal layout designing

The article presents the issue of container handling processes at a rail-road intermodal terminal. In the article, we have focused on the problem of a terminal layout design from the point of view of parking lots for external trucks. The main purpose of this article is the assessment of the necessary parking lots for the trucks considering daily turnover of containers and the trucks appointment time windows. We analyze how the length of the truck’s appointment time windows as well as the difficulties in containers loading operations and a number of handling equipment influence the necessary parking lots for trucks in the intermodal terminal. The trucks planned for loading of import containers may arrive at the terminal before the loading moment that is specified in crane operations schedule. The container handling time is given by a probability distribution. The equations defining the most important elements of the considered problem were presented in the general form. The special case of this model has been developed in the FlexSim simulation software. Based on the simulation research and calculations we pointed out that right truck’s appointment time windows can significantly reduce necessary parking lots at the yard. The literature analysis presented in the article indicates that most of the research in the field of intermodal terminal is focused on operations in container ports. There is lack of literature considering rail-road terminal layout planning in terms of the necessary parking lots and truck’s appointment time windows.
Big Data Analysis Application for Road Accident with Decision Tree

— In transportation field, an enormous measure of information gathered by IOTframeworks, remote detecting and other information accumulation apparatuses brings new difficulties; the span of this information turns out to be amazingly huge and progressively complex for customary methods of information mining. To manage this test, Apache Spark remain as an amazing huge scale circulated processing stage that can be utilized effectively for machine learning against exceptionally expansive databases. This work utilized substantial scale machine learning strategies particularly Decision Tree with Apache Spark system for enormous information investigation to assemble a model that can foresee the elements lead to street mishaps dependent on a few info factors identified with auto collisions. In view of this, the anticipating model first preprocesses the huge mishap information and investigates it to make information for a learning framework. Observational outcomes demonstrate that the proposed model could give new data that can help the leaders to break down and enhance street wellbeing.
ANTHROPOGENIC DISTURBANCES AND RESILIENCE: A MESSAGE FROM THE PAST

Despite of the number of studies that have been conducted, knowledge of past human activities on peatlands in Southeast (SE) Asia remains fragmented. Hence, anthropogenic activities on peatlands are considered to be recent. In order to see whether and how human conducted activities on peatland in the past, a palaeoecological study on peatland located close to archaeological site of Malayu Empire was undertaken. The results revealed that human activities on tropical peatland began over a millennium ago. By conducting logging, grazing and wild harvesting activities, human changed the vegetation composition and diminished the ecosystem ability to accumulate peat and carbon. Shortly after the abandonment of the site, the vegetation regenerated and the accumulation rate of carbon recovered.
A literature survey of security indicators in web browsers

The web browser security indicators are one of the main tools helping users to identify fraudulent (e.g., phishing) websites. The research in detection of phishing websites focuses predominantly on automated solutions for blocking potentially harmful websites and only rarely considers other measures such as security indicators that help users to recognise phishing websites and human factors associated with them. To gather the key ﬁndings on the efﬁciency of the security indicators and human factors affecting it, a systematic survey of the literature in major scientiﬁc databases has been conducted. The survey reveals that the security indicators may help users to recognise the phishing websites, however, the users often fail to consider them while evaluating the websites’ authenticity. The key potential factors are the lack of users’ knowledge, poor design and inappropriate placement of the security indicators in web browsers. Additional challenges stem from searching for the balance between the visibility and discretion of the security indicators as an intrusive design or placement may induce the users’ annoyance.