Miracle-dz/UniFAR-FTUs huggingface dataset:
Improve Interpretability of Neural Networks via Sparse Contrastive Coding

Although explainable artiﬁcial intelligence (XAI) has achieved remarkable developments in recent years, there are few efforts have been devoted to the following problems, namely, i) how to develop an explainable method that could explain the black-box in a model-agnostic way? and ii) how to improve the performance and interpretability of the black-box using such explanations instead of pre-collected important attributions? To explore the potential solution, we propose a model-agnostic explanation method termed as Sparse Contrastive Coding (SCC) and verify its effectiveness in text classiﬁcation and natural language inference. In brief, SCC explains the feature attributions which characterize the importance of words based on the hidden states of each layer of the model. With such word-level explainability, SCC adaptively divides the input sentences into foregrounds and backgrounds in terms of task relevance. Through maximizing the similarity between the fore-grounds and input sentences while minimizing the similarity between the backgrounds and input sentences, SSC employs a supervised contrastive learning loss to boost the interpretability and performance of the model. Extensive experiments show the superiority of our method over ﬁve state-of-the-art methods in terms of interpretability and classiﬁcation measurements. The code is available at https: //pengxi.me .
ℋ︁∞ model reduction for uncertain two‐dimensional discrete systems

This paper investigates the problem of ℋ︁∞ model reduction for two‐dimensional (2‐D) discrete systems with parameter uncertainties residing in a polytope. For a given robustly stable system, our attention is focused on the construction of a reduced‐order model, which also resides in a polytope and approximates the original system well in an ℋ︁∞ norm sense. Both Fornasini–Marchesini local state‐space (FMLSS) and Roesser models are considered through parameter‐dependent approaches, with sufficient conditions obtained for the existence of admissible reduced‐order solutions. Since these obtained conditions are not expressed as strict linear matrix inequalities (LMIs), the cone complementary linearization method is exploited to cast them into sequential minimization problems subject to LMI constraints, which can be readily solved using standard numerical software. In addition, the development of zeroth order models is also presented. Two numerical examples are provided to show the effectiveness of the proposed theories. Copyright © 2005 John Wiley & Sons, Ltd.
FIRST AND SECOND ORDER SUFFICIENT CONDITIONS FOR STRICT MINIMALITY IN MULTIOBJECTIVE PROGRAMMING

ABSTRACT In this paper, first and second order sufficient conditions are established for strict local Pareto minima of orders 1 and 2 to multiobjective optimization problems with an arbitrary feasible set and a twice differentiable objective function are provided. For this aim, the concept of support function to a multiobjective problem is introduced, so that the scalar case in particular is contained. The obtained results generalize the classical ones of this case. Furthermore, particularizing to a feasible set defined by equality and inequality constraints, first and second order optimality conditions in primal form as well as dual form (by means of a Lagrange multiplier rule) are obtained.
Maximal pulmonary ventilation and lactate affect the anaerobic performance in young women exposed to hypobaric hypoxia

Background: Athletes, tourists, and mining workers from all over the world ascend daily to an altitude greater than 3.000 meters above sea level to perform different activities, all of which demand physical effort. A ventilation increase is the first mechanism once the chemoreceptors perceive hypoxia, and is key to maintaining blood oxygen levels during acute exposure to high altitudes and to buffering lactic acidosis during exercise. It has been observed that gender is a variable that can influence the ventilatory response. Still, the available literature is limited due to the few studies considering women as study subjects. The influence of gender on anaerobic performance and its effects under high altitudes (HA) environments have been poorly studied. Objective: The objectives of this study were to evaluate anaerobic performance in young women exposed to high altitudes and to compare the physiological response to multiple sprints between women and men measured by ergospirometry. Methodology: Nine women and nine men (22.9 ± 3.2 years old) carried out the multiple-sprint anaerobic tests under two conditions, sea level and high altitudes. Results: In the first 24 h of exposure to a high altitudes, lactate levels were higher in women than those in men (2.57 ± 0.4 Mmol/L, 2.18 ± 0.3 Mmol/L, respectively; p < 0.05). Second, women had a decreased ventilatory response in exposure to high altitudes compared to men (p > 0.005). Third, there is a positive correlation between lactate levels prior to an anaerobic test and the ventilatory response developed by subjects at high altitudes (R2 = 0.33, slope = -41.7, and p < 0.05). Lastly, this ventilatory response can influence VO2peak (R2 = 0.60, slope = 0.02, and p < 0.001). Conclusion: This study provides insights into the mechanisms behind the reduced respiratory capacity observed in women during an anaerobic exercise test at high altitudes. An acute response to HA showed a greater work of breathing and increased the drive ventilatory response. It is possible to postulate the differences in the fatigue-induced metaboreflex of the respiratory muscles and aerobic–anaerobic transition between genders. These results on multiple sprint performance and the influences of gender in hypoxic environments deserve further investigation.
Executive function abilities in cognitively healthy young and older adults—A cross-sectional study

A prominent feature of cognitive aging is the decline of executive function (EF) abilities. Numerous studies have reported that older adults perform poorer than younger adults in such tasks. In this cross-sectional study, the effect of age on four EFs, inhibition, shifting, updating, and dual-tasking, was examined in 26 young adults (mean 21.18 years) and 25 older adults (mean 71.56 years) with the utilization of a pair of tasks for each EF. The tasks employed for DT were the Psychological Refractory Period paradigm (PRP) and a modified test for everyday attention, for inhibition the Stroop and Hayling sentence completion test (HSCT), for shifting a task switching paradigm and the trail making test (TMT), and for updating the backward digit span (BDS) task and a n-back paradigm. As all participants performed all tasks, a further aim was to compare the size of the age-related cognitive decline among the four EFs. Age-related decline was observed in all four EFs in one or both of the tasks employed. The results revealed significantly poorer performance in the older adults in the response times (RTs) of the PRP effect, interference score of the Stroop, RT inhibition costs of the HSCT, RT and error-rate shifting costs of the task switching paradigm, and the error-rate updating costs of the n-back paradigm. A comparison between the rates of decline revealed numerical and statistically significant differences between the four EFs, with inhibition showing the greatest decline, followed by shifting, updating, and dual-tasking. Thus, we conclude that with age, these four EFs decline at different rates.
Specialty grand challenge: Smarter solutions for tinnitus

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Editorial: Generation of Functional tissues from human pluripotent stem cells

Dear readers, Human pluripotent stem cells (hPSCs), including embryonic stem cells isolated from the inner cell mass of a blastocyst (Thomson et al., 1998) and induced pluripotent stem cells (iPSCs) reprogrammed from somatic cells (Takahashi et al., 2007), could self-renew in vitro and have the potential to differentiate into any cell types of three germ layers. hPSCs and their derived cells could be used for genetic disease modeling, pathogenic mechanism investigation, and drug screening, and also provide unlimited cell resources for regenerative medicine. However, due to the differences between in vitro stem cell differentiation and in vivo development, most hPSCs-derived cells resemble fetal-stage cells and are not fully mature. Worldwide efforts are still on the way to generate functional tissue cells from stem cells. For this aim, we launched the specific Research Topic “Generation of Functional Tissues from Human Pluripotent Stem Cells” to highlight the latest progress to make functional cells from hPSCs and their applications. Throughout this Research Topic, we compiled various research papers from expert laboratories around the world within this exciting field of research.
Radiation safety considerations for the use of radium-224-calciumcarbonate-microparticles in patients with peritoneal metastasis

Aim Two ongoing phase I studies are investigating the use of radium-224 adsorbed to calcium carbonate micro particles (224Ra-CaCO3-MP) to treat peritoneal metastasis originating from colorectal or ovarian cancer. The aim of this work was to study the level of radiation exposure from the patients to workers at the hospital, carers and members of the public. Method Six patients from the phase 1 trial in patients with colorectal cancer were included in this study. Two days after cytoreductive surgery, they were injected with 7 MBq of 224Ra-CaCO3-MP. At approximately 3, 24 and 120 h after injection, the patients underwent measurements with an ionization chamber and a scintillator-based iodide detector, and whole body gamma camera imaging. The patient was modelled as a planar source to calculate dose rate as a function of distance. Scenarios varying in duration and distance from the patient were created to estimate the potential effective doses from external exposure. Urine and blood samples were collected at approximately 3, 6, 24, 48 and 120 h after injection of 224Ra-CaCO3-MP, to estimate the activity concentration of 224Ra and 212Pb. Results The patients’ median effective whole-body half-life of 224Ra-CaCO3-MP ranged from 2.6 to 3.5 days, with a mean value of 3.0 days. In the scenarios with exposure at the hospital (first 8 days), sporadic patient contact resulted in a range of 3.9–6.8 μSv per patient, and daily contact resulted in 4.3–31.3 μSv depending on the scenario. After discharge from the hospital, at day 8, the highest effective dose was received by those with close daily contact; 18.7–83.0 μSv. The highest activity concentrations of 224Ra and 212Pb in urine and blood were found within 6 h, with maximum values of 70 Bq/g for 224Ra and 628 Bq/g for 212Pb. Conclusion The number of patients treated with 224Ra-CaCO3-MP that a single hospital worker - involved in extensive care - can receive per year, before effective doses of 6 mSv from external exposure is exceeded, is in the order of 200–400. Members of the public and family members are expected to receive well below 0.25 mSv, and therefore, no restrictions to reduce external exposure should be required.
Biocompatibility and osteoinductive ability of casein phosphopeptide modified polyetheretherketone

Polyetheretherketone (PEEK) is a potential implant material for dental application due to its excellent mechanical properties. However, its biological inertness and poor osteoinductive ability limited its clinical application. Based on a lay-by-layer self-assembly technique, here we incorporated casein phosphopeptide (CPP) onto PEEK surface by a simple two-step strategy to address the poor osteoinductive ability of PEEK implants. In this study, the PEEK specimens were positively charged by 3-ammoniumpropyltriethoxysilane (APTES) modification, then the CPP was adsorbed onto the positively charged PEEK surface electrostatically to obtain CPP-modified PEEK (PEEK-CPP) specimens. The surface characterization, layer degradation, biocompatibility and osteoinductive ability of the PEEK-CPP specimens were studied in vitro. After CPP modification, the PEEK-CPP specimens had a porous and hydrophilic surface and presented enhanced cell adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 cells. These findings indicated that CPP modification could significantly improve the biocompatibility and osteoinductive ability of PEEK-CPP implants in vitro. In a word, CPP modification is a promising strategy for the PEEK implants to achieve osseointegration.
Effects of hemicellulose on intestinal mucosal barrier integrity, gut microbiota, and metabolomics in a mouse model of type 2 diabetes mellitus

Background and objective Impaired gut barrier contributes to the progression of type 2 diabetes mellitus (T2DM), and the gut microbiota and metabolome play an important role in it. Hemicellulose, a potential prebiotics, how its supplementation impacted the glucose level, the impaired gut barrier, and the gut microbiota and metabolome in T2DM remained unclear. Methods In this study, some mice were arranged randomly into four groups: db/db mice fed by a compositionally defined diet (CDD), db/db mice fed by a CDD with 10% and 20% hemicellulose supplementation, and control mice fed by a CDD. Body weight and fasting blood glucose levels were monitored weekly. The gut barrier was evaluated. Fresh stool samples were analyzed using metagenomic sequencing and liquid chromatography-mass spectrometry to detect gut microbiota and metabolome changes. Systemic and colonic inflammation were evaluated. Results Better glycemic control, restoration of the impaired gut barrier, and lowered systemic inflammation levels were observed in db/db mice with the supplementation of 10 or 20% hemicellulose. The gut microbiota showed significant differences in beta diversity among the four groups. Fifteen genera with differential relative abundances and 59 significantly different metabolites were found. In the db/db group, hemicellulose eliminated the redundant Faecalibaculum and Enterorhabdus. The increased succinate and ursodeoxycholic acid (UDCA) after hemicellulose treatment were negatively correlated with Bifidobacterium, Erysipelatoclostridium, and Faecalibaculum. In addition, hemicellulose reduced the colonic expressions of TLR2/4 and TNF-α in db/db mice. Conclusion Hemicellulose may serve as a potential therapeutic intervention for T2DM by improving impaired intestinal mucosal barrier integrity, modulating gut microbiota composition, and altering the metabolic profile.
Scattering of p-modes by a sunspot

The acoustic scattering properties of a large sunspot are determined from a Fourier-Hankel decomposition of p-mode amplitudes as measured from a 68-hr subset of a larger set of observations made at the South Pole in 1988. It is shown that significant improvement in the measurement of p-mode scattering amplitudes results from the increased temporal frequency resolution provided by these data. Scattering phase shifts are unambiguously determined for the first time, and the dependence of the p-mode phase shift and absorption with wavenumber and frequency is presented.
Soft robotics in wearable and implantable medical applications: Translational challenges and future outlooks

This work explores the recent research conducted towards the development of novel classes of devices in wearable and implantable medical applications allowed by the introduction of the soft robotics approach. In the medical field, the need for materials with mechanical properties similar to biological tissues is one of the first considerations that arises to improve comfort and safety in the physical interaction with the human body. Thus, soft robotic devices are expected to be able of accomplishing tasks no traditional rigid systems can do. In this paper, we describe future perspectives and possible routes to address scientific and clinical issues still hampering the accomplishment of ideal solutions in clinical practice.
Relocation of bioclimatic suitability of Portuguese grapevine varieties under climate change scenarios

Introduction Climate change has been driving warming trends and changes in precipitation patterns and regimes throughout Europe. Future projections indicate a continuation of these trends in the next decades. This situation is challenging the sustainability of viniculture and, thus, significant efforts towards adaptation should be then carried out by local winegrowers. Method Ecological Niche Models were built, using the ensemble modelling approach, to estimate the bioclimatic suitability of four main wine-producing European countries, namely France, Italy, Portugal, and Spain, in the recent past (1989–2005), for the cultivation of twelve Portuguese grape varieties. The models were then used to project the bioclimatic suitability to two future periods (2021– 2050 and 2051–2080) to better understand the potential shifts related to climate change (modeled after Intergovernmental Panel on Climate Change’s Representative Concentration Pathways 4.5 and 8.5 scenarios). The models were obtained with the modeling platform BIOMOD2, using four bioclimatic indices, namely the “Huglin Index”, the “Cool Night index”, the “Growing Season Precipitation index”, and the “Temperature Range during Ripening index” as predictor variables, as well as the current locations of the chosen grape varieties in Portugal. Results All models performed with high statistical accuracy (AUC > 0.9) and were able to discriminate several suitable bioclimatic areas for the different grape varieties, in and around where they are currently located but also in other parts of the study area. The distribution of the bioclimatic suitability changed, however, when looking at future projections. For both climatic scenarios, projected bioclimatic suitability suffered a considerable shift to the north of Spain and France. In some cases, bioclimatic suitability also moved towards areas of higher elevation. Portugal and Italy barely retained any of the initially projected varietal areas. These shifts were mainly due to the overall rise in thermal accumulation and lower accumulated precipitation in the southern regions projected for the future. Conclusion Ensemble models of Ecological Niche Models were shown to be valid tools for winegrowers who want to adapt to a changing climate. The long-term sustainability of viniculture in southern Europe will most likely have to go through a process of mitigation of the effects of increasing temperatures and decreasing precipitation.
Contemporary trends in psychological research on conspiracy beliefs. A systematic review

Background The number of psychological studies on conspiracy beliefs has been systematically growing for about a dozen years, but in recent years, the trend has intensified. We provided a review covering the psychological literature on conspiracy beliefs from 2018 to 2021. Halfway through this period, the COVID-19 pandemic broke out, accompanied by an explosion of movements based on conspiracy theories, intensifying researchers’ interest in this issue. Methods Adhering to PRISMA guidelines, the review systematically searched for relevant journal articles published between 2018 and 2021. A search was done on Scopus and Web of Science (only peer-reviewed journals). A study was included if it contained primary empirical data, if specific or general conspiracy belief(s) were measured and if its correlation with at least one other psychological variable was reported. All the studies were grouped for the descriptive analysis according to the methodology used, the participants’ characteristics, the continent of origin, the sample size, and the conspiracy beliefs measurement tools. Due to substantial methodological heterogeneity of the studies, narrative synthesis was performed. The five researchers were assigned specific roles at each stage of the analysis to ensure the highest quality of the research. Results Following the proposed methodology, 308 full-text articles were assessed for eligibility and 274 articles (417 studies) meeting the inclusion criteria were identified and included in the review. Almost half of the studies (49.6%) were conducted in European countries. The vast majority of the studies (85.7%) were carried out on samples of adult respondents. The research presents antecedents as well as (potential) consequences of conspiracy beliefs. We grouped the antecedents of conspiracy beliefs into six categories: cognitive (e.g., thinking style) motivational (e.g., uncertainty avoidance), personality (e.g., collective narcissism), psychopathology (e.g., Dark Triad traits), political (e.g., ideological orientation), and sociocultural factors (e.g., collectivism). Conclusion and limitations The research presents evidence on the links between conspiracy beliefs and a range of attitudes and behaviors considered unfavorable from the point of view of individuals and of the society at large. It turned out that different constructs of conspiracy thinking interact with each other. The limitations of the study are discussed in the last part of the article.
High mobility indium free amorphous oxide thin film transistors

High mobility bottom gate thin film transistors (TFTs) with an amorphous gallium tin zinc oxide (a-GSZO) channel layer have been produced by rf magnetron cosputtering using a gallium zinc oxide (GZO) and tin (Sn) targets. The effect of postannealing temperatures (200, 250, and 300°C) was evaluated and compared with two series of TFTs produced at room temperature (S1) and 150°C (S2) during the channel deposition. From the results, it was observed that the effect of postannealing is crucial for both series of TFTs either for stability as well as for improving the electrical characteristics. The a-GSZO TFTs (W∕L=50∕50μm) operate in the enhancement mode (n-type), present a high saturation mobility of 24.6cm2∕Vs, a subthreshold gate swing voltage of 0.38V/decade, a turn-on voltage of −0.5V, a threshold voltage of 4.6V, and an Ion∕Ioff ratio of 8×107, satisfying all the requirements to be used as active-matrix backplane.