Miracle-dz/UniFAR-FTUs huggingface dataset:
Interaction effects between insomnia and depression on risk of out-of-hospital cardiac arrest: Multi-center study

Background Insomnia and depression have been known to be risk factors of several diseases, including coronary heart disease. We hypothesized that insomnia affects the out-of-hospital cardiac arrest (OHCA) incidence, and these effects may vary depending on whether it is accompanied by depression. This study aimed to determine the association between insomnia and OHCA incidence and whether the effect of insomnia is influenced by depression. Methods This prospective multicenter case-control study was performed using Phase II Cardiac Arrest Pursuit Trial with Unique Registration and Epidemiology Surveillance (CAPTURES-II) project database for OHCA cases and community-based controls in Korea. The main exposure was history of insomnia. We conducted conditional logistic regression analysis to estimate the effect of insomnia on the risk of OHCA incidence and performed interaction analysis between insomnia and depression. Finally, subgroup analysis was conducted in the patients with insomnia. Results Insomnia was not associated with increased OHCA risk (0.95 [0.64–1.40]). In the interaction analysis, insomnia interacted with depression on OHCA incidence in the young population. Insomnia was associated with significantly higher odds of OHCA incidence (3.65 [1.29–10.33]) in patients with depression than in those without depression (0.84 [0.59–1.17]). In the subgroup analysis, depression increased OHCA incidence only in patients who were not taking insomnia medication (3.66 [1.15–11.66]). Conclusion Insomnia with depression is a risk factor for OHCA in the young population. This trend was maintained only in the population not consuming insomnia medication. Early and active medical intervention for patients with insomnia may contribute to lowering the risk of OHCA.
Identification of clinical phenotypes associated with poor prognosis in patients with nonalcoholic fatty liver disease via unsupervised machine learning

Both fibrosis status and body weight are important for assessing prognosis in nonalcoholic fatty liver disease (NAFLD). The aim of this study was to identify population clusters for specific clinical outcomes based on fibrosis‐4 (FIB‐4) index and body mass index (BMI) using an unsupervised machine learning method.
BANMo: Building Animatable 3D Neural Models from Many Casual Videos: SUPPLEMENTARY MATERIALS

Figure 1. Inference pipeline of PoseNet. To initialize the optimization, we train a CNN PoseNet to predict root poses given a single image. PoseNet uses a DensePose-CNN to extract pixel features and decodes the pixel features into root pose predictions with a ResNet-18. We visualize the initial root poses on the right. Cyan color represents earlier time stamps and magenta color represent later timestamps.
A mixture model-based discriminate analysis for identifying ordered transcription factor binding site pairs in gene promoters directly regulated by estrogen receptor-alpha

MOTIVATION To detect and select patterns of transcription factor binding sites (TFBSs) which distinguish genes directly regulated by estrogen receptor-alpha (ERalpha), we developed an innovative mixture model-based discriminate analysis for identifying ordered TFBS pairs. RESULTS Biologically, our proposed new algorithm clearly suggests that TFBSs are not randomly distributed within ERalpha target promoters (P-value < 0.001). The up-regulated targets significantly (P-value < 0.01) possess TFBS pairs, (DBP, MYC), (DBP, MYC/MAX heterodimer), (DBP, USF2) and (DBP, MYOGENIN); and down-regulated ERalpha target genes significantly (P-value < 0.01) possess TFBS pairs, such as (DBP, c-ETS1-68), (DBP, USF2) and (DBP, MYOGENIN). Statistically, our proposed mixture model-based discriminate analysis can simultaneously perform TFBS pattern recognition, TFBS pattern selection, and target class prediction; such integrative power cannot be achieved by current methods. AVAILABILITY The software is available on request from the authors. CONTACT lali@iupui.edu SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Closing the B+-tree vs. LSM-tree Write Amplification Gap on Modern Storage Hardware with Built-in Transparent Compression

This paper studies how B + -tree could take full advantage of modern storage hardware with built-in transparent compression. Recent years witnessed signiﬁcant interest in applying log-structured merge tree (LSM-tree) as an alternative to B + - tree, driven by the widely accepted belief that LSM-tree has distinct advantages in terms of storage cost and write ampliﬁ-cation. This paper aims to revisit this belief upon the arrival of storage hardware with built-in transparent compression. Advanced storage appliances and emerging computational storage drives perform hardware-based lossless data compression, transparent to OS and user applications. Beyond straight-forwardly reducing the storage cost gap between B + -tree and LSM-tree, such storage hardware creates new opportunities to re-think the implementation of B + -tree. This paper presents three simple design techniques that can leverage such modern storage hardware to signiﬁcantly reduce the B + -tree write ampliﬁcation. Experiments on a commercial storage drive with built-in transparent compression show that the proposed design techniques can reduce the B + -tree write ampliﬁcation by over 10 × . Compared with RocksDB (a key-value store built upon LSM-tree), the enhanced B + -tree implementation can achieve similar or even smaller write ampliﬁcation.
COMPARISON OF EPIDURAL WITH ILIOPSOAS PLANE CATHETER INSERTION FOR PROVIDING POST-OPERATIVE ANALGESIA IN HIP SURGERIES

Background: Anaesthesiologists play an important role in post-operative pain management. For analgesia after lower abdominal surgery, epidural analgesia and iliopsoas plane block are suitable options. The study aims to compare the analgesic efficacy of both techniques. Materials and Methods: Sixty patients were divided into Group T (30 patients treated with Iliopsoas Plane Block) and Group I (30 patients treated with Epidural block). All patients had a detailed pre-aesthetic examination. Standard monitors, including NIBP, ECG, and Pulse Oximeter, were attached, and baseline vitals were recorded. Patients from both groups underwent hip surgery under spinal anaesthesia with 3.5 ml 0.5% Bupivacaine (heavy). Result: Male predominance was reported in group E, whereas female predominance was observed in Group I. The mean age, weight, height, and ASA grading were comparable in both Group E and I. The mean onset of sensory block was reported to be significantly lower in group I. In contrast, the duration of analgesia and the total number of top-ups were significantly higher in Group I. The mean VAS score was statistically significant between groups from 2 to 14 hours and 18 hours. The mean SBP was statistically significant at 0.5 and 1 hour and MDB at 0, 0.5, 8 and 10 hours. The MAP was statically significant at 0.5, 8 and 10 hours. At the all-time point, there was a statistical difference in Bromage score between groups E and I. Conclusion: The iliopsoas plane block holds considerable promise as an effective post-operative analgesia and motor sparing with fewer side effects than Epidural analgesia.
Investigating school quality and learning outcomes among adolescents in Malawi

E ducation, particularly at the primary level, has long been regarded as an essential input of social and economic development. In addition to its direct role in increasing the cognitive abilities of students, schooling is recognized as a facilitator of labor force participation, female empowerment, improved health outcomes, and greater civic engagement. In acknowledgment of the importance of schooling for future opportunities, as well as of persistent barriers to access in the developing world, universal primary education was listed as one of the eight United Nations Millennium Development Goals to be achieved by 2015. While it is clear that this goal will not be met, many countries have nonetheless made significant strides in improving access to primary schooling. The challenge they face is to increase the number of students without sacrificing the quality of education each receives. As one of the early pioneers in sub-Saharan Africa of free primary education, Malawi’s enrollment figures compare favorably with those of its neighbors in southern Africa. Before the elimination of fees in 1994, fewer than half of children attended primary school, but by 1999 net enrollment had reached 99 percent (United Nations Statistics Division 2010). However, this increase in access has not been accompanied by a corresponding investment in infrastructure and resources, such that “Malawi’s decade-old, underfinanced and largely unplanned experiment in moving almost overnight to universal primary education is generally regarded as a failure” (Kenny 2010). Indeed, primary school completion rates stand at just 35 percent, while attainment of basic literacy and numeracy skills remains among the lowest in the region (World Bank 2010).
RELAÇÃO ENTRE OTIMISMO E ONDAS DE FUSÃO E AQUISIÇÃO: EVIDÊNCIAS DO MERCADO BRASILEIRO

RESUMO O motivo de as fusões e aquisições (F&As) acontecerem em ondas é ainda um tema pouco explorado na literatura financeira, especialmente no contexto de mercados fora dos EUA e Reino Unido. Diante disso, o presente trabalho investiga se o otimismo dos agentes econômicos pode levar a uma onda de F&As, utilizando dados brasileiros entre 2007 e 2017 sobre as transações e o Índice de Confança do Empresário, que mede o otimismo dos empresários com a situação atual e futura da economia. Foi utilizada a definição de onda de F&As como em Harford (2005). A partir de um modelo de resposta binária logit, os resultados apontam que o otimismo aumenta a probabilidade de ocorrência de uma onda de F&As. O Ibovespa foi a variável que apresentou maior efeito nas probabilidades de ocorrência de uma onda de F&As. Os resultados foram significantes para diferentes lags.
The Shifting Meaning of Happiness

An examination of emotions reported on 12 million personal blogs along with a series of surveys and laboratory experiments show that the meaning of happiness is not fixed; instead, it systematically shifts over the course of one's lifetime. Whereas younger people are more likely to associate happiness with excitement, as they get older, they become more likely to associate happiness with peacefulness. This change appears to be driven by a redirection of attention from the future to the present as people age. The dynamics of happiness has implications from purchasing behavior to ways to increase one's happiness.
Deep Neck Space Infections: Scope, Dangers and Predictors of Outcome in an Emerging Economy

1 Department of Oto-Rhinolaryngology, Head & Neck Surgery, College of Medicine, University of Jos & Jos University Teaching Hospital, Plateau State, Nigeria. 2 Department of Oral & Maxillofacial Surgery, College of Medicine, University of Jos & Jos University Teaching Hospital, Plateau State, Nigeria. 3 Department of Oto-Rhinolaryngology, Head & Neck Surgery, Jos University Teaching Hospital, Plateau State, Nigeria. 4 Department Of Anaesthesia, College of Medicine, University of Jos & Jos University Teaching Hospital, Plateau state, Nigeria. 5 Department of General Surgery, College of Medicine, University of Jos & Jos University Teaching Hospital, Plateau State, Nigeria.
Design patterns of hierarchies for order structures

Using order structures in a proof assistant naturally raises the problem of working with multiple instances of a same structure over a common type of elements. This goes against the main design pattern of hierarchies used for instance in Coq ’s MathComp or Lean ’s mathlib libraries, where types are canonically associated to at most one instance and instances share a common overloaded syntax. We present new design patterns to leverage these issues, and apply them to the formalization of order structures in the MathComp library. A common idea in these patterns is underloading , i.e., a disambiguation of operators on a common type. In addition, our design patterns include a way to deal with duality in order structures in a convenient way. We hence formalize a large hierarchy which includes partial orders, semilattices, lattices as well as many variants. We finally pay a special attention to order substructures. We introduce a new kind of structure called prelattice . They are abstractions of semilattices, and allow us to deal with finite lattices and their sublattices within a common signature. As an application, we report on significant simplications of the formalization of the face lattices of polyhedra in the Coq-Polyhedra library.
UvA-DARE (Digital Academic Self-similar jet evolution after drop impact on a liquid surface

Small conical-shaped jets may emanate from a liquid bath a short while after a small drop has hit a liquid pool. Here we perform Particle Image Velocimetry (PIV) measurements of the liquid ﬂow inside upward jets after drop impact and show that ﬂuid elements inside the jets may decelerate up to 5–20 times the gravitational acceleration. The measurements show that both the shape of the jet and the velocity proﬁle are self-similar. A theoretical model including surface tension, ﬂuid inertia and gravity correctly predicts the self-similar velocity proﬁle and shape of the jet, allowing us to provide the ﬁrst quantitative explanation of the shape and dynamics of the emanating jets.
Routledge Handbook of Theory in Sport Management

The participating gamers responded to a questionnaire measuring brand awareness, brand attitude and purchase intentions. Results from the MANCOVA revealed that after controlling for the effect of the covariates, the experimental group had a signiﬁcantly greater mean brand awareness score than the control group. Mean brand attitude and purchase intention scores were not signiﬁcantly different among groups.
Development of high throughput SNP marker panels for genotyping of pathogenic bacteria

Bacteria colonise almost every known habitat on earth and pose some of the greatest threats to public health. They do this through the great genetic variation between and within species. These traits allow colonies to develop new strategies to survive e.g. evading host immune responses or becoming resistant to antibiotics. In this project we have taken advantage of the swathes of sequence data available for a range of bacteria and used this to identify key single nucleotide polymorphisms (SNPs) in each species. These SNPs were ranked by our minimal marker pipeline in order of resolving power to create SNP marker panels which could be used to discriminate between hundreds of isolates of the same species. Our results showed that, for most species tested, over 99% of isolates of a single species could be resolved from one another using between just seven and 15 SNP markers. A panel of the most informative SNP markers for Campylobacter jejuni was created and used to genotype DNA samples from eight unseen isolates in the lab. The alleles displayed by each isolate at the 13 SNP markers used displayed sufficient diversity to allow us to discriminate between all eight isolates.
COMBINATION OF AST TO PLATELET RATIO (APRI) AND FIB4 (FIBROSIS) SCORING TO DETECT AND STAGE FIBROSIS IN CHRONIC LIVER DISEASE

Background: Patients with chronic liver disease have been reported with a poor prognosis which can lead to liver cirrhosis. The current study aims to assess the combination of APRI and FIB-4 scores to detect fibrosis and stages of fibrosis in patients with chronic liver disease to better assess mortality, prognosis, and treatment outcome without using invasive techniques such as liver biopsy. Materials and Methods: The cross-sectional study was conducted at the Kanyakumari Government Medical College for a duration of the 1-year follow-up period among 100 patients. Patients diagnosed with liver cirrhosis were included in the current study, whereas patients with any other systemic disease or inflammation were excluded. Data collection was based on the detailed history interview, APRI, FIB-4 scores, general and systemic examination, and serum AST/ALT and platelet levels. Result: The current study reports a male predominance (60.0%) with an affected age group of 51-60 (33.0%). A significant difference was reported between the serum AST, ALT, and platelet levels with stages of liver fibrosis (p-value <0.0001). The use of APRI and FIB-4 scores accurately predict and differentiate liver fibrosis stages in patients with a cut-off value of 0.72 and 2.15. A sensitivity of 75% and specificity of 71.90% were seen for APRI scores, whereas the FIB-4 score reported 83.30% sensitivity and 67.16% specificity. Conclusion: The use of APRI and FIB-4 scores appears to be accurate in diagnosing stages of liver fibrosis and differentiating between stages F3 and F4 in chronic liver disease patients.
MORPHOMETRIC ANALYSIS OF NECK SHAFT ANGLE AND HEAD CIRCUMFERENCE OF ADULT DRY FEMUR BONE IN SOUTH INDIAN POPULATION

Background: Femur, the thigh bone, is the strongest and longest bone in the human skeletal system. The head of the femur fits in the acetabulum cavity to allow smooth mobility. It is necessary to perform morphometric analysis of the femur before constructing the implants and prosthesis for the hip joint in total hip replacement surgeries. Aim: The measure of neck-shaft angle and the femur head circumference in the South Indian population as a sample. Materials and Methods: An observation study was performed on 100 dry femur adult bones of the South Indian population available at Department of Anatomy, Government medical college & ESI hospital, Coimbatore, Tamilnadu. Fifty bones were from the left limb, and 50 bones were from the right limb. Bones with fracture, deformation or any pathology were excluded. The angle between the neck and shaft (neck-shaft angle), for both the femur (left and right), was measured with a handheld 360° goniometer, and femur head circumference was measured with a flexible tape. Result: The mean angle of the femur of the right leg was 127.44°, while that of the left femur was 127.10°. The mean head circumference of the right femur and left femur were 133.41 mm and 130.73 mm, respectively. Conclusion: The data obtained with this study can be used in designing and constructing the implants and prostheses for hip surgery. The data may also be a base for future studies
EFFECT OF ACUTE MYOCARDIAL INFARCTION ON CHOLESTEROL RATIOS

Background: Myocardial infarction generally occurs with the abrupt decrease in coronary blood flow that follows a thrombotic occlusion of a coronary artery previously narrowed by atherosclerosis. Present study aimed to study effects of acute myocardial infarction (MI) on cholesterol ratios. Materials and Methods: The study was conducted at the intensive coronary care unit and medical wards of Tirunelveli Medical College Hospital, Tirunelveli during the period of August 2004 to August 2005. The serum lipid profile was measured within the first 24 hours of the onset of symptoms of myocardial infarctions and again at day 4 post myocardial infarctions. The serum total cholesterol, triglyceride levels, total cholesterol / HDL cholesterol and LDL cholesterol / HDL ratios were recorded for all patients. Result: Total 100 patients with confirmed diagnosis of acute myocardial infarction fulfilling the criteria were enrolled in the study. Total serum cholesterol (190.10  25.75 vs 172.50  27.05 mg/dL) and triglycerides (124.98  38.35 mg/dL vs 143.22  35.64 mg/dL) showed significant increase from Day 1 post MI to Day 4 post MI. The ratio of total cholesterol to HDL cholesterol and the ratio of LDL cholesterol to HDL cholesterol was 4.30  0.36 on day 1 post-MI and 4.38  0.36 on day 4 post-MI and 2.71  0.40 on day 1 post-MI and 2.69  0.38 on day 4 post-MI respectively. Conclusion: T MI significantly reduces the total serum cholesterol levels and increases the serum triglyceride levels. But the MI has no significant effect on the cholesterol ratios.
Evaluation Of Effect Of Aqueous And Ethanolic Extracts Of Pithecellobium Bijeninum Leaves On Wound Healing

The objective of the present investigation was to evaluate the wound healing action of Pithecellobium bijeninum leaf extract in rats. Successive solvent extraction of the leaves of Pithecellobium bijeninum was performed using petroleum ether and ethanol by soxhlet method and distilled water by cold maceration method. The acute toxicity study suggests a LD 50 of more than 2000 mg/Kg for both the ethanolic and aqueous extracts of the plant. The ethanolic and aqueous extracts of Pithecellobium bijeninum leaves were evaluated for the in vivo wound healing effect by the excision model. The topical application of 5 % w/w of the Pithecellobium bijeninum resulted in an enhanced and statistically significant (p < 0.05) wound healing activity in vivo when using the ethanolic extract. The wound healing by the aqueous extract was not significant in comparison to the control group. The ethanolic extract exhibited 82.1861 ± 5.86 % contraction of wound on the 20 th day whereas only 49.2866 ± 5.46 % contraction of wound was found in the control animals. On the other hand, the maximum coverage of wound by the aqueous extract on the 20 th day of treatment was 67.4664 ± 3.011 %. The standard drug (povidone) was able to contract 89.1449 ± 4.20 % of the wound in comparison to the 1 st day and exhibited significant action (p<0.01).
Infectious Diseases, Biodiversity and Global Changes: How the Biodiversity Sciences May Help

Biodiversity has been reduced on an unprecedented scale over the last decades (MEA, 2005). Concomitantly, new infectious diseases have emerged (or re-emerged) at an increasing rate (Wilcox & Gubler, 2005; Jones et al., 2008) through human impacts on ecosystems, which are supposed to influence this (re-)emergence of diseases (Chivian & Berstein, 2004; Patz et al. 2004). According to the Millenium Ecosystem Assessment (MEA, 2005), biodiversity helps at regulating diseases, with disease regulation as one of the services provided by ecosystems (Walpole et al., 2009). According to this report, high level of species diversity is supposed to reduce or to buffer the risk of disease transmission (MEA 2005). However, greater overall biodiversity is often shown to be linked to a greater diversity of pathogens (Poulin & Morand, 2004). Thereby, high biodiversity should be linked to high incidence of infectious diseases (Dunn et al., 2010). The reasons of the discrepancy between biodiversity loss and the increasing rate of infectious diseases and the persistence of numerous infectious diseases need a special attention on the likely mechanisms that could link biodiversity and infectious diseases. Several studies provide evidences that support both of these views. Here, the main questions are how biodiversity is linked to infectious diseases, and how biodiversity sciences may help at improving health.
Recursive Small-Step Multi-Agent A ∗ for Dec-POMDPs

We present recursive small-step multi-agent A ∗ (RS-MAA ∗ ), an exact algorithm that optimizes the expected reward in decentralized partially observable Markov decision processes (Dec-POMDPs). RS-MAA ∗ builds on multi-agent A ∗ (MAA ∗ ), an algorithm that finds policies by exploring a search tree, but tackles two major scalability concerns. First, we employ a modified, small-step variant of the search tree that avoids the double exponential outdegree of the classical formulation. Second, we use a tight and recursive heuristic that we compute on-the-fly, thereby avoiding an expensive precom-putation. The resulting algorithm is conceptually simple, yet it shows superior performance on a rich set of standard benchmarks.