Miracle-dz/UniFAR-FTUs huggingface dataset:
Indirect effects of the COVID-19 pandemic on paediatric healthcare use and severe disease: a retrospective national cohort study

Objectives To determine the indirect consequences of the COVID-19 pandemic on paediatric healthcare utilisation and severe disease at a national level following lockdown on 23 March 2020. Design National retrospective cohort study. Setting Emergency childhood primary and secondary care providers across Scotland; two national paediatric intensive care units (PICUs); statutory death records. Participants 273 455 unscheduled primary care attendances; 462 437 emergency department attendances; 54 076 emergency hospital admissions; 413 PICU unplanned emergency admissions requiring invasive mechanical ventilation; and 415 deaths during the lockdown study period and equivalent dates in previous years. Main outcome measures Rates of emergency care consultations, attendances and admissions; clinical severity scores on presentation to PICU; rates and causes of childhood death. For all data sets, rates during the lockdown period were compared with mean or aggregated rates for the equivalent dates in 2016–2019. Results The rates of emergency presentations to primary and secondary care fell during lockdown in comparison to previous years. Emergency PICU admissions for children requiring invasive mechanical ventilation also fell as a proportion of cases for the entire population, with an OR of 0.52 for likelihood of admission during lockdown (95% CI 0.37 to 0.73), compared with the equivalent period in previous years. Clinical severity scores did not suggest children were presenting with more advanced disease. The greatest reduction in PICU admissions was for diseases of the respiratory system; those for injury, poisoning or other external causes were equivalent to previous years. Mortality during lockdown did not change significantly compared with 2016–2019. Conclusions National lockdown led to a reduction in paediatric emergency care utilisation, without associated evidence of severe harm.
Frameshift PQBP-1 mutants

Polyglutamine tract-binding protein-1 (PQBP-1) is a nuclear intrinsically disordered protein playing important roles in transcriptional regulation and RNA splicing during embryonic and postembryonic development. In human, its mutations lead to severe cognitive impairment known as the Renpenning syndrome, a form of X-linked intellectual disability (XLID). Here, we report a combined biophysical study of two PQBP-1 frameshift mutants, K192S fs*7 and R153S fs*41 . Both mutants are dimeric in solution, in contrast to the monomeric wild-type protein. These mutants contain more folded contents and have increased thermal stabilities. Using small-angle X-ray scattering data, we generated three-dimensional envelopes which revealed their overall flat shapes. We also described each mutant using an ensemble model based on a native-like initial pool with a dimeric structural core. PQBP-1 is known to repress transcription by way of interacting with the C-terminal domain of RNA polymerase II, which consists of 52 repeats of a consensus heptapeptide sequence YSPTSPS. We studied the binding of PQBP-1 variants to the labelled peptide which is phosphorylated at positions 2 and 5 (YpSPTpSPS) and found that this interaction is significantly weakened in the two mutants.
Diﬀerential forms on log canonical spaces in positive characteristic

Given a logarithmic 1 -form on the snc locus of a log canonical surface pair ( X, D ) over a perfect ﬁeld of characteristic p (cid:2) 7 , we show that it extends with at worst logarithmic poles to any resolution of singularities. We also prove the analogous statement for regular diﬀerential forms, under an additional tameness hypothesis. In addition, residue and restriction sequences for tamely dlt pairs are established. We give a number of examples showing that our results are sharp in the surface case
Real-time identiﬁcation using gait pattern analysis on a standalone wearable accelerometer

Wearable devices can gather sensitive information about their users. For this reason, automated authentication and identiﬁcation techniques are increasingly adopted to ensure security and privacy. Furthermore, identiﬁcation can be used to automatically customize operations according to the needs of the current user. A gait-based identiﬁcation method that can be executed in real time on devices with limited resources is here presented. The method exploits a wearable accelerometer to continuously analyze the user’s gait pattern and perform identiﬁcation. Experiments were conducted with ten volunteers, who carried the device in a trouser pocket and followed their daily routine without predeﬁned constraints. In total, ∼ 98 hours of acceleration traces were collected in uncontrolled environment, including 3073 gait segments. User identiﬁcation results show a recognition rate ranging from 95% to 100%, depending on the mode of operation. It is demonstrated that the method can be executed on a standalone device with less than 8 KB of RAM. In addition, the energy consumption is evaluated and compared with an architecture that requires the presence of an external computing unit. Results show that the proposed solution signiﬁcantly improves the lifetime of the device (approximately +70% for the considered platform), hence fostering user acceptance.
Edinburgh Research Explorer Fruit softening

• Background and Aims The programmed softening occurring during fruit development requires scission of cell wall polysaccharides, especially pectin. Proposed mechanisms include the action of wall enzymes or hydroxyl radicals. Enzyme activities found in fruit extracts include pectate lyase (PL) and endo-polygalacturonase (EPG), which, in vitro , cleave de-esterified homogalacturonan in mid-chain by β -elimination and hydrolysis, respectively. However, the important biological question of whether PL exhibits action in vivo had not been tested. • Methods We developed a method for specifically and sensitively detecting in-vivo PL products, based on Driselase digestion of cell wall polysaccharides and detection of the characteristic unsaturated product of PL action. • Key Results In model in-vitro experiments, pectic homogalacturonan that had been partially cleaved by commercial PL was digested to completion with Driselase, releasing an unsaturated disaccharide (‘ Δ UA–GalA’), taken as diagnostic of PL action. Δ UA–GalA was separated from saturated oligogalacturonides (EPG products) by electrophoresis, then subjected to thin-layer chromatography (TLC), resolving Δ UA–GalA from higher homologues. The Δ UA–GalA was confirmed as 4-deoxy-β -l- threo -hex-4-enopyranuronosyl-(1 → 4)-d-galacturonic acid by NMR spectroscopy. Driselase digestion of cell walls from ripe fruits of date ( Phoenix dactylifera ), pear ( Pyrus communis ), rowan ( Sorbus aucuparia ) and apple ( Malus pumila ) yielded Δ UA–GalA, demonstrating that PL had been acting in vivo in these fruits prior to harvest. Date-derived Δ UA–GalA was verified by negative-mode mass spectrometry, including collision-induced dissociation (CID) fragmentation. The Δ UA–GalA:GalA ratio from ripe dates was roughly 1:20 (mol mol –1 ), indicating that approx. 5 % of the bonds in endogenous homogalacturonan had been cleaved by in-vivo PL action. • Conclusions The results provide the first demonstration that PL, previously known from studies of fruit gene expression, proteomic studies and in-vitro enzyme activity, exhibits enzyme action in the walls of soft fruits and may thus be proposed to contribute to fruit softening.
Gender Di (cid:11) erences in Sports News Coverage on Twitter

: Gender stereotypes inﬂuence boys’ and girls’ self-perception, with the di (cid:11) erential treatment received by sports ﬁgures in the media being one of the main factors in the perpetuation of stereotypes about sports. The objective of this research is to analyze if the new communication channels, such as Twitter, maintain gender stereotypes when reporting sports news. For this purpose, the four most followed media in Spain were analyzed: ( @ElPais_Deportes , @ABC_Deportes , @Marca and @MundoDeportivo ) over a period of ﬁve months, from March to June 2016. Our sample was composed of 6544 tweets, with 96.19% about sportsmen compared to 3.81% that portrayed women. The sport with the most media coverage was football (72.11%), for men as well as for women, followed by basketball (6.63%). It is clear that despite the growing international triumphs of Spanish women athletes in recent years, the latter continue to be underrepresented in the media. Female athletes receive more media coverage according to the sport which they engage in (“gender-appropriate” sports), with the exception of football, and not in accordance with their accomplishments. Twitter remains at the service of traditional media replicating the same gender biases and even augmenting them.
Handbook of Research on Global Business Opportunities

Innovation is a key factor for surviving and competing in the global scenario. However, findings from existing studies provide conflicting evidence in this regard, and the relationship between company innovation and performance remains undetermined. This chapter aims to deepen our understanding of this subject by looking at a less studied topic: the relationship between the innovation scope of a firm and its performance. The study is based on empirical research carried out in a sample of 74 firms belonging to the Friuli Wine Cluster located in northeastern Italy. Empirical results support the view that the most successful winemakers are those who have a wider innovation scope and who, in the last years, have considerably revised their innovation-related processes in a more market-and experience-related way.
Management of pericardial effusion

Pericardial effusion is a common finding in everyday practice. Sometimes, its cause is obviously related to an underlying general or cardiac disease, or to a syndrome of inflammatory or infectious acute pericarditis. On other occasions, pericardial effusion is an unexpected finding that requires specific evaluation. In these cases, the main issues are aetiology, the clinical course, and the possibility of evolution to haemodynamic embarrassment. This is especially relevant in cases of large pericardial effusions, in which echocardiographic recordings not infrequently show findings suggestive of subclinical haemodynamic derangement, mainly right atrial or right ventricular wall collapse. These uncertainties have led to a heterogeneous approach to the management of the syndrome of pericardial effusion by different groups of investigators. The main goal of this article is to give a comprehensive review of aetiology, haemodynamic findings, and management of pericardial effusion. In addition, some comments on the management of neoplastic pericardial effusion are also provided. In an asymptomatic patient, a pericardial effusion of less than 10 mm on the echocardiogram may be an incidental finding, especially in elderly women, as shown in the Framingham study.1 In these patients, neither invasive studies nor treatment are required. A follow up echocardiogram is probably warranted to see if the echocardiographic findings are unchanged. Further investigation or treatment of these patients is not necessary if the echo findings are stable. A wide variety of conditions may result in pericardial effusion. All types of acute pericarditis (inflammatory, infectious, immunologic or of physical origin) can be associated with pericardial effusion.2 In addition, pericardial effusion of varying degrees can be seen in other conditions such as neoplasia (with or without direct pericardial involvement), myxoedema, renal insufficiency, pregnancy, aortic or cardiac rupture, trauma, chylopericardium, or in the setting of chronic salt and water retention of many causes, including chronic heart …
Differential Geometry and its Applications

In order to look for a well-behaved counterpart to Dolbeault cohomology in D -complex geometry, we study the de Rham cohomology of an almost D -complex manifold and its subgroups made up of the classes admitting invariant, respectively anti-invariant, representatives with respect to the almost D -complex structure, miming the theory introduced by Li and Zhang (2009) in [20] for almost complex manifolds. In particular, we prove that, on a 4-dimensional D -complex nilmanifold, such subgroups provide a decomposition at the level of the real second de Rham cohomology group. Moreover, we study deformations of D -complex structures, showing in particular that admitting D - Kähler structures is not a stable property under small deformations. © 2012 Elsevier B.V. All rights reserved.
전단 해류 환경에서 동적 전력케이블의 VIV 피로해석 절차에 관한 기초 연구

The subsea power cables are increasingly important for harvesting renewable energies as we develop offshore wind farms located at a long distance from shore. Particularly, the continuous flexural motion of inter-array dynamic power cable of floating offshore wind turbine causes tremendous fatigue damages on the cable. As the subsea power cable consists of the helical structures with various components unlike a mooring line and a steel pipe riser, the fatigue analysis of the cables should be performed using special procedures that consider stick/slip phenomenon. This phenomenon occurs between inner helically wound components when they are tensioned or compressed by environmental loads and the floater motions. In particular, Vortex-induced vibration (VIV) can be generated by currents and have significant impacts on the fatigue life of the cable. In this study, the procedure for VIV fatigue analysis of the dynamic power cable has been established. Additionally, the respective roles of programs employed and required inputs and outputs are explained in detail. Demonstrations of case studies are provided under severely sheared currents to investigate the influences on amplitude variations of dynamic power cables caused by the excitation of high mode numbers. Finally, sensitivity studies have been performed to compare dynamic cable design parameters, specifically, structural damping ratio, higher order harmonics, and lift coefficients tables. In the future, one of the fundamental assumptions to assess the VIV response will be examined in detail, namely a narrow-banded Gaussian process derived from the VIV amplitudes. Although this approach is consistent with current industry standards, the level of consistency and the potential errors between the Gaussian process and the fatigue damage generated from deterministic time-domain results are to be confirmed to verify VIV fatigue analysis procedure for slender marine structures.
Video Games as a Tool for Digital Emotion Regulation

As the use of digital technology plays an increasingly important role in people’s daily lives, there is a growing concern about its impact on people’s emotional and mental health. Although previous studies have suggested that video games as a popular digital technology can help people unintentionally shape their emotions, little is known about how people actively use them as a tool to regulate their emotions. Therefore, the study aims to investigate the role of digital games in facilitating emotion regulation during the coronavirus crisis and identify best practices to help people manage their emotional and mental wellbeing. Forty participants were recruited to participate in two online interviews, with a 4-day diary study in between. After given instructions in the first interview, participants kept diaries of their engagement with digital emotion regulation and shared their experiences in the subsequent interview. We analyzed the data using thematic analysis to understand how people use video games to manipulate their emotions. The results showed that people played more games to socialize and mediate their negative emotions during lockdown. Meanwhile, people had different motives and different games impacted emotion regulation differently. Despite some concerns about the game use, people had their own strategies to avoid drawbacks and considered playing video games as an overall positive experience for emotion regulation. The findings imply that digital games are actively utilized as a tool to manage emotions and the social connection can be further explored as a lens for evaluating the effectiveness of games on emotion regulation.
How Unobservable Productivity Biases the Value of a Statistical How Unobservable Productivity Biases the Value of a Statistical Life Life

A prominent theoretical controversy in the compensating differentials literature concerns unobservable individual productivity. Competing models yield opposite predictions depending on whether the unobservable productivity is safety-related skill or productivity generally. Using five panel waves and several new measures of worker fatality risks, first-difference estimates imply that omitting individual heterogeneity leads to overestimates of the value of statistical life, consistent with the latent safety-related skill interpretation. Risk measures with less measurement error raise the value of statistical life, the net effect being that estimates from the static model range from $5.3 million to $6.7 million, with dynamic model estimates somewhat higher.
Intra-Operative Supplementary Motor Area Aphasia During Awake Craniotomy: A Case Report

40-year-old patient with left frontal lobe lesion involving motor and speech area who underwent awake craniotomy under scalp block and titrated sedation. Though resection was in safe zone as marked both by neuro-navigaton and direct electrical stimulation, patient developed aphasia intra-operatively. The aphasia resolved post-operatively with speech therapy over two weeks. Resection in Supplementary motor area (SMA) in the dominant hemisphere may be the likely cause of aphasia in this patient, resulting in reversible SMA syndrome. Conclusion: SMA syndrome must be considered as differential diagnosis of deficit during awake craniotomy when resection is in SMA.
Strategic Technical Partnerships between Entrepreneurs and Corporate Ventures for Competitiveness and Sustainable Development in Nigeria

A b s t r a c t ntrepreneurs, their start-ups and businesses in Nigeria and Africa/ E experience many challenges and few survive two to ﬁve-year range. Some of the challenges include lack of business savageness and plans, handful corporate investors and venture capitals and the need for these fund centers to appropriately understand entrepreneurs, their businesses and markets. The study examined the structures and operations of the strategic technical partnership between corporate investors/venture capitals and entrepreneurs businesses for enhancing sustainable business performance innovation and competitiveness. Such corporate include banks, governments, private equities, investors and non-governmental organizations operating in banking, ﬁnancing agricultural, energy and power, and other technological sectors. Findings showed there exists urgent need for more alliance, understanding and patience with the enterprises, structures and markets by corporate investors and capitals. These bodies can organize as syndicates to help in funding research and innovations in project execution and marketing strategies and stretching new technologies. It is recommended for the development of the entrepreneurial spirits, more of training, coaching and mentoring of the business desiring and trainable entrepreneurs in view of the weaknesses noticed in Nigerian entrepreneurs.
Edinburgh Research Explorer Above and beyond emotional suffering

Objectives: Studieshaveshownthatself-compassionplaysa protectiveroleagainstdepressioninwomenwithchronicpain (CP). However,themajorityofstudiesinCPhaveusedthetotal score of the self-compassion scale (SCS), which have raised concerns due to potential overlap, not only between the un-compassionate self-responding factors and psychopathology, but also between self-compassion as a whole and other well-known psychological processes (e.g., mindfulness, acceptance, psychological flexibility). This calls for a more nuanced understanding of which components of (un)compassionate self-responding adds to better mental health in CP. Methods: This study explores the unique contribution of compassionate and uncompassionate self-responding to depressive symptoms in women with CP undergoing pain consultation (n = 49). Results: Correlation analyses suggest that compassionate self-responding only significantly correlates with progress in valued living, while the uncompassionate self-responding significantly correlates with pain fusion, pain avoidance, obstructions to valued living and depression. Multiple regression analysis showed that self-compassion contributes to depressive symptoms (R 2 = 8%) above and beyond pain intensity and disability (R 2 = 12%) and psychological (in) ﬂ exibility processes (R 2 = 31%), and un-compassionate (but not compassionate) self-responding uniquely contributes to depressive symptoms ( sr 2 = 18%). Conclusions: Findings suggest thatuncompassionate self-responding is a stronger contributor to depression in CP than compassionate self-responding. Clinical implications are further discussed.
Vascular Anomalies Embolization of Extracranial Head and Neck Safety and Clinical Efficacy of Onyx for

BACKGROUND AND PURPOSE: Onyx was developed for embolization of central nervous system AVMs but is increasingly used extracranially because of its unique physical properties. We review our experience and results with the use of Onyx for the treatment of fast-flow extracranial vascular lesions. MATERIALS AND METHODS: We retrospectively analyzed clinical and imaging records of 22 patients who underwent 71 extracranial embolizations from March 2007 through January 2010. The diagnoses were the following: cervicofacial AVM ( n (cid:1) 18), traumatic fistula ( n (cid:1) 3), and vessel laceration ( n (cid:1) 1). In 62 of 71 procedures (87%), Onyx was the sole embolic agent; it was delivered trans-arterially in 67/71 and percutaneously in 4/71 procedures. Clinical goals included amelioration of pain and control of bleeding. The clinical efficacy of embolization was judged by symptom control, and adverse events were assessed by clinical examination and history, both postembolization and 4 weeks postprocedure. RESULTS: Cessation of acute bleeding was achieved in 13/14 cases, with 1 case of immediate recurrent massive epistaxis prompting reintubation and further embolization. Control of subacute bleeding episodes and pain was achieved for all patients. Following staged embolization, 7 patients underwent surgical resection without significant blood loss. Surgeons reported high satisfaction with the intraoperative handling properties of Onyx. Transient swelling, local tenderness, or numbness was encountered after 7 procedures. There were no stuck catheters, vessel dissections, or vessel ruptures and no skin discoloration. CONCLUSIONS: Staged Onyx embolization was clinically efficacious in managing extracranial fast-flow vascular malformations and lesions, with low associated morbidity. ABBREVIATIONS