Miracle-dz/UniFAR-FTUs huggingface dataset:
University of Birmingham AMIGO3 is an NgR1/p75 co-receptor signalling axon growth inhibition in the acute phase of adult central nervous system injury

Axon regeneration in the injured adult CNS is reportedly inhibited by myelin-derived inhibitory molecules, after binding to a receptor complex comprised of the Nogo-66 receptor (NgR1) and two transmembrane co-receptors p75/TROY and LINGO-1. However, the post-injury expression pattern for LINGO-1 is inconsistent with its proposed function. We demonstrated that AMIGO3 levels were significantly higher acutely than those of LINGO-1 in dorsal column lesions and reduced in models of dorsal root ganglion neuron (DRGN) axon regeneration. Similarly, AMIGO3 levels were raised in the retina immediately after optic nerve crush, whilst levels were suppressed in regenerating optic nerves, induced by intravitreal peripheral nerve implantation. AMIGO3 interacted functionally with NgR1-p75/TROY in non-neuronal cells and in brain lysates, mediating RhoA activation in response to CNS myelin. Knockdown of AMIGO3 in myelin-inhibited adult primary DRG and retinal cultures promoted disinhibited neurite growth when cells were stimulated with appropriate neurotrophic factors. These findings demonstrate that AMIGO3 substitutes for LINGO-1 in the NgR1-p75/TROY inhibitory signalling complex and suggests that the NgR1-p75/TROY-AMIGO3 receptor complex mediates myelin-induced inhibition of axon growth acutely in the CNS. Thus, antagonizing AMIGO3 rather than LINGO-1 immediately after CNS injury is likely to be a more effective therapeutic strategy for promoting CNS axon regeneration when combined with neurotrophic factor administration. NgR1 and p75/TROY in both transfected cells and rat and human brain lysates, forming a functional receptor complex that activates RhoGTP in cells exposed to CNS myelin extracts (CME); and (4), siRNA-mediated knockdown of AMIGO3 significantly enhances DRGN and RGC neurite outgrowth in CME-inhibited cultures when stimulated with appropriate neurotrophic factors (NTF). These results suggest that AMIGO3 substitutes for LINGO-1 in centrally axotomized DRGN and RGC in the acute phase of injury and that the NgR1-p75/TROY-AMIGO3 receptor complex mediates immediate axon growth inhibitory responses to CNS myelin.
Psychopathic traits and deviant sexual interests

The present study examined associations between psychopathic traits and deviant sexual interests across gender in a large community sample ( N ¼ 429, 24% men). Correlation analyses supported the positive link between psychopathic traits and deviant sexual interests. Regression analyses indicated that the unique variance in the antisocial facet of psychopathy predicted all six deviant sexual interests. The interpersonal facet predicted voyeuristic and exhibitionistic interests, whereas the affective facet predicted pedophilic interests. Moderation analyses revealed that gender moderated most of the relations between the antisocial facet of psychopathy and deviant sexual interests, such that those positive associ- ations were stronger among women. On the contrary, the associations between the interpersonal facet and voyeuristic interests, as well as between the lifestyle facet and sadistic interests, were stronger among men. Findings appear to suggest that deviant sexual inter- ests represent a domain in which the manifestation of psychopathic traits may differ across gender. These findings emphasize the relevance of psychopathic traits for the understand- ing and risk assessment of sexual deviance, while suggesting the need for gender-sensitive considerations.
Salivary Lactoferrin in HIV-Infected Children: It’s Importance on Antifungal Activity against Oral Candida Albicans Infections

Children living with HIV constitute a population highly susceptible to a variety of opportunistic infections, among which oral candidiasis is the most common oral manifestation, despite its decreased prevalence after introduction of the treatment with highly active antiretroviral therapy. Among the pathogens, Candida albicans is responsible for most of the oral lesions in HIV-infected patients, which, after the initial adhesion and multiplication, starts to penetrate and invade host tissues. These mechanisms are related to the production and secretion of hydrolases such as proteases and phospholipases. Its diversity and abundance is influenced by host’s specific and non-specific components, such as lactoferrin, which is a multifunctional glycoprotein, from metalloproteins group, which performs iron transport. Lactoferrin is present in various body fluids such as saliva, tears, semen, sweat, colostrum, milk and nasal secretions in the innate immune system, especially for protecting the mucosal surface from microbial infections. This article aimed to review studies evaluating the role of salivary lactoferrin in the modulation of Candida spp infection and possible mechanisms of evasion used by Candida spp. in HIV-infected children. In conclusion, despite the fact that lactoferrin harbors a significant antifungal effect against Candida spp. , the prevalence of oral candidiasis is still high among HIV-infected children, so it is important to investigate the evasion mechanisms involved on this fungus resistance to conventional treatments, in order to justify the high incidence of candidiasis among pediatric patients living with HIV.
Comparative in vitro activity of oritavancin against are resistant, intermediate or heteroresistant to vancomycin

1. Galimand M, Courvalin P, Lambert T. Plasmid-mediated highlevel resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation. Antimicrob Agents Chemother 2003; 47: 2565–71. 2. Doi Y, Arakawa Y. 16S ribosomal RNA methylation: emerging resistance mechanism against aminoglycosides. Clin Infect Dis 2007; 45: 88–94. 3. Bogaerts P, Galimand M, Bauraing C et al. Emergence of ArmA and RmtB aminoglycoside resistance 16S rRNA methylases in Belgium. J Antimicrob Chemother 2007; 59: 459–64. 4. Naas T, Lezzar A, Bentchouala C et al. Multidrug-resistant Salmonella enterica serotype Senftenberg isolates producing CTX-M b-lactamases from Constantine, Algeria. J Antimicrob Chemother 2005; 56: 439–40. 5. Gołebiewski M, Kern-Zdanowicz I, Zienkiewicz M et al. Complete nucleotide sequence of the pCTX-M3 plasmid and its involvement in spread of the extended-spectrum b-lactamase gene blaCTX-M-3. Antimicrob Agents Chemother 2007; 51: 3789–95. 6. Galimand M, Sabtcheva S, Courvalin P et al. Worldwide disseminated armA aminoglycoside resistance methylase gene is borne by composite transposon Tn1548. Antimicrob Agents Chemother 2005; 49: 2949–53. 7. Wu Q, Zhang Y, Han L et al. Plasmid-mediated 16S rRNA methylases in aminoglycoside-resistant Enterobacteriaceae isolates in Shanghai, China. Antimicrob Agents Chemother 2009; 53: 271–2.
Case studies in Physiology: Analysis of the World record time for combined father marathon

The aim of this study was to examine the physiological profiles and the pacing strategies of 35 the father (59 years old) and son (34 years old) who broke the World record time (4:59:22; 36 father : 2:27:52, son : 2:31:30) for combined father and son marathon in 2019. Oxygen uptake 37 (V̇O 2 ), heart rate (HR), ventilation (V̇E), blood lactate concentration (La), and running 38 economy (RE) were measured during treadmill-running tests. The total distance of the 39 marathon was divided into 8 sections of 5 km and 1 last section of 2.195 km, and the relative 40 average running velocity on each section was calculated individually. V̇O 2max , HR max , V̇E max , 41 La max , were 65.4 ml.kg -1 . min -1 , 165 beats.min -1 , 115 l.min -1 , 5.7 mmol.l -1 for the father and 42 66.9 ml.kg -1 . min -1 , 181 beats.min -1 , 153 l.min -1 , 11.5 mmol.l -1 for the son, respectively. At 17 43 km.h -1 , RE was 210 ml.kg -1 . km -1 for the father and 200 ml.kg -1 . km -1 for the son, and % 44 V̇O 2max sustained was 90.9% for the father and 84.5% for the son, respectively. The father 45 maintained an even running velocity during the marathon (running velocity CV < 1%) while 46 the son ran the second half-marathon 7% slower than the first one, and his running velocity 47 markedly dropped from the 35 th kilometer. Father and son who broke the World record time 48 for combined father and son marathon had a similar level of performance but their 49 physiological profiles and pacing strategies during the marathon were different. A more even 50 speed for the son could help them to improve their own record in a near future.
NEW EYES OF ID - HOW TO PREPARE NEW INDUSTRIAL REVOLUTION AS INDUSTRIAL DESIGNER

At the turning point of technological innovation, an intriguing question is how industrial designers can bridge gap between human and technology. The role of the industrial designer in the traditional view of the physical appearance of objects may be reduced, but in the future, designing meaning with object through rich interaction is becoming a wiser way of preparing for a new industrial revolution. The purpose of this paper is to discuss the changing role of designers through theoretical reviews with case studies.
Synthesis and Effect of Nonhydrolyzable Xanthosine Triphosphate Derivatives on Prenylation of Rab5 D136N

SUMMARY A novel and convenient method for nucleoside triphosphate synthesis was applied to the preparation of potentially nonhydrolyzable xanthosine triphosphate derivatives. The N -methy- limidazolide of xanthosine 5 (cid:57) -monophosphate reacted rapidly with methylenediphosphonic acid and imidodiphosphonic acid to give xanthosine 5 (cid:57) -( (cid:98) , (cid:103) -methylene)triphosphate and xanthosine 5 (cid:57) -( (cid:98) , (cid:103) -imido)triphosphate, respectively, in good yields. Both compounds inhibited the xanthosine-diphosphate-depen- dent prenylation of a mutant of Rab5, Rab5 D136N , the nucleotide specificity of which had been converted from GTP to xanthosine triphosphate. The results indicate that xanthosine 5 (cid:57) -( (cid:98) , (cid:103) -methylene)triphosphate and xanthosine 5 (cid:57) -( (cid:98) , (cid:103) -imido)-triphosphate bound to the mutant protein with similar affinities and were not hydrolyzed under the assay conditions. These novel derivatives may be useful tools for the study of the role of individual GTPases mutated to xanthosine triphosphate specificity in the background of other GTP-binding proteins.
Genomic epidemiology of in uenza B circulation in China during prolonged border closure from 2020 to 2021

Ruopeng Xie The University of Hong Kong Dillon Adam The University of Hong Kong Kimberly Edwards The University of Hong Kong https://orcid.org/0000-0003-0944-3118 Shreya Gurung The University of Hong Kong Xiaoman Wei The University of Hong Kong Benjamin Cowling University of Hong Kong https://orcid.org/0000-0002-6297-7154 Vijaykrishna Dhanasekaran (  veej@hku.hk ) The University of Hong Kong https://orcid.org/0000-0003-3293-6279
Coffee Based Rehabilitation of Degraded Land : the Case of Haru District, West Oromia, Ethiopia

: Managing the environment in which people live has become more complex. As a result millions of people have become food insecure due to natural resource degradation. In the past few decades rehabilitation efforts have been made to counterbalance environmental degradation. However its implementation has not been successful in most cases, due to various barriers. The study aims at exploring the potential of coffee based rehabilitation strategies, while supporting the livelihood of smallholder farmers. The study was conducted at Haru district found in west Wallaga, Oromia, Ethiopia. A plot of 20 m x 20m was laid to collect vegetation data from 40 coffee farms. Socioeconomics information were collected through household interview using structured and semi structured questionnaire and focus group discussion. The result indicates that 15108ha of degraded land was rehabilitated through coffee based land use system. Vegetation assessment result showed that twenty nine species were recorded in sampled coffee farms. The proportion of indigenous tree and shrubs, exotic fruit tree and shrubs accounted for 79.3%, 17.2 % and 3.5% respectively. Similarly more than 50 percent of the coffee production was found on degraded land greater than 16% slopes. The Shannon diversity index was calculated 2.8. Given the increasingly important issue of land management coffee based land use systems was found among the most promising land uses for achieving both conservation goals and supporting human livelihoods at the landscape scale by promoting community- based management of natural resources.
The Short-Term E cacy of Tenofovir Alafenamide (TAF) in Acute-On-Chronic Liver Failure: A Single Center Experience

Zhiqin Li (  lizhiqinyfy@163.com ) The First A liated Hospital of Zhengzhou University Yang Liu The First A liated Hospital of Zhengzhou University https://orcid.org/0000-0002-5582-0685 Jianxia Dong The First A liated Hospital of Zhengzhou University Jingya Yan The First A liated Hospital of Zhengzhou University Yushu Hu The First A liated Hospital of Zhengzhou University Meng Wang The First A liated Hospital of Zhengzhou University
The Impact Parental Control on Emotional Regulation amongst Adolescents in Fako Division

This paper examines the impact of parental control on emotional regulation amongst adolescents in Fako Division. Increasing parenting trends across the globe are taking new turns as it is becoming increasingly difficult for parents to bond with their folks and in turn build a rich social and emotional relationship amongst parents and children. Regulating emotions well is critical for promoting social and emotional health among children and adolescents. Parents play a prominent role in how children develop emotion regulation. The objects of the present research are to address the perception of parental control, emotional regulation and its challenges. In 2007, Morris et al. proposed a tripartite model suggesting that parents influence children’s emotion regulation through three mechanisms: children’s observation of parents’ emotion regulation, emotion-related parenting practices, and the emotional climate of the family. The study comprise a web based survey, analyses of literature, involving an excellent review of relevant articles in addition to deductive content analysis of the data generated; and it equally examine some challenges of parental control on emotional regulation. In light of the data that have been collected there is a correlation between addressing parental control and adolescent’s emotional regulation. Further, the findings show that parental control has an impact on the emotional regulation of adolescents; this thus influences their development and the quality of their emotional relationships.
Lean implementation in a service factory: views from the front-line

Abstract The deployment of Lean methods in service work is increasingly viewed as a legitimate response more efficient front-line service delivery. However, there are mixed results with process efficiency gains frequently marginalised by losses in employee satisfaction and customer focus. It is suggested that these sub-optimal outcomes result from partial adoptions of Lean with emphasis on process efficiency neglecting employee and customer outcomes. Utilising Action Research this paper investigates a Lean implementation within a UK call centre. This research finds that Lean when implemented properly can lead to improved process efficiency, a better customer experience and increased employee satisfaction. It suggests that to achieve these optimum outcomes Lean implementations must as a priority be focused on creating customer satisfaction and be customised to fit with particular contingencies in the organisational context such as the nature of the interface between the front-line worker and the customer.
Physicochemical and sensory analysis of surimi sausage incorporated with rolled oat powder subjected to frying

In the present work, the effects of rolled oat powder (ROP) incorporated into surimi sausage on the physicochemical and sensory attributes of sausage were investigated. The incorporation of ROP into surimi sausage significantly increased moisture content, protein content, and water holding capacity, but decreased shrinkage and cooking loss. The incorporation of ROP was also able to significantly decrease fat absorption during frying. However, increased amount of ROP caused a significant decrease in texture especially after frying. Although a decrease in texture was recorded, the sensory analysis score did not display any significant difference on the colour, hardness, and overall acceptability of the surimi sausage. The development of surimi sausage incorporated with ROP could be an approach to utilise fish as a commodity, and produce a healthier and more nutritious sausage even after frying.
Evaluating of Microwave Drying for Hawthorn Slice as Alternative to Convective Drying

: This study aimed to investigate the influence of microwave drying with different power levels as alternative to convective drying method on drying kinetics and main quality attributes of hawthorn slice. At increasing microwave power values, higher drying rate and shorter drying time was observed. The page model was found to give best fit ( R 2 > 0.9961, RMSE < 0.028 and χ 2 < 0.675x10 -3 ) for all drying treatments. Although the minimum change of color and texture value were obtained at microwave power of 600 W, the convective drying caused less total color and texture change depending fresh sample. Drying process at microwave powers of 600 W and 360 W showed the best quality in terms of rehydration and bioactive properties, respectively. The findings in current work demonstrated that microwave drying at 360 W microwave power might be suitable for drying of hawthorn slices with high quality and bioactive properties as well as low operating costs.
Applying Design Thinking to systemic problems in educational assessment information management

The integrative process of design thinking provides a compelling framework for addressing problems in education involving coherent assessment and instruction. New possibilities for more meaningful developmental coherence within, horizontal coherence across, and vertical coherence between classroom formative and accountability assessments emerge by thinking through and enacting conceptual solutions that begin with the end in mind and that involve end users every step of the way. The nonlinear process involves empathy for students and teachers, the definition of a solvable problem (one with solutions that are feasible, viable, and desirable), the ideation of a brainstormed array of ideal “possibly impossible” resources for creativity (such as a very demanding measurement model and traceability to unit standards), the rapid development of an initial prototype expected to have limitations, and the first of an iterative series of tests that deliberately test the prototype en route to a recycling as needed through any other parts of the process. Applying Design Thinking may lead to new solutions to problems encountered in reconceiving and reconfiguring classrooms as meta-design ecosystem niches of creativity and innovation. An assessment outcome prototype drawn from recent work with teacher/educators that integrates developmental, horizontal, and vertical coherence is presented.
Modeling and Solving Method for Supporting ‘Vehicle-to-Anything’ EV Charging Mode

: Electric vehicles (EVs) are an attractive solution to make traditional transportation energy-efﬁcient and environmentally friendly. EVs are also considered an important element to bring new opportunities for power grids. In addition to the role of a pure load, along with the development of discharging technology for batteries, EVs can deliver energy back to power grids or another power consumption entity or community, performing various discharging activities such as vehicle-to-home (V2H), vehicle-to-building (V2B), vehicle-to-vehicle (V2V), vehicle-to-grid (V2G), etc. These charging scenarios can be uniformly named the ‘Vehicle-to-anything’ (V2A) charging mode. The paradigm of this charging mode has already been given; however, the modeling and solving approaches are still insufﬁcient. Therefore, the analysis and modeling of V2A are investigated herein. propose a generic model suitable for different applications of in different places. The characteristics of the charging mode are given and analyzed ﬁrst. Then a model that can adapt to the V2A scenario is illustrated. The optimization problem is transformed and solved as an INLP (integer nonlinear programming) problem. The effectiveness of the approach is veriﬁed with simulation results. The outcome also indicates that V2A applications have great potential for lowering power consumption costs; for instance, a reduction of 4.37% in energy expense can be achieved in a case study with EV discharging enabled for a household.
Optimal Configuration of Energy Storage System Coordinating Wind Turbine to Participate Power System Primary Frequency Regulation

Large scale wind power integration has a negative influence on the frequency response. Assistant measurement improves the frequency stability of power systems under high wind penetration. The Proportional Curtailment Strategy (PCS) for wind turbines provides a primary frequency reserve for power systems. To solve the worthless curtailed wind power, the PCS is used to improve the utilization of wind power curtailment. Then the wind turbine and the lithium battery Energy Storage System (ESS) provide primary frequency reserves together. Different control strategies of ESS have been proposed based on the different methods for selecting valid reserves. The economic benefits of different control strategies have been compared based on the same frequency regulation reserve. The optimal control strategy is the maximum method. The economic benefit of the maximum value method is ¥4,445,300.
V 605 Aquilae - A star and a nebula with no hydrogen

Monthly Notices Roy. Astron. Soc. 175, 19 P. Hippelein, H. H. , Weinberger, R. , 1975, Astron. Astrophys. , 43, 405. Pettersson, B. : 1987, Astron. Astrophys. 171, 101. Reipurth, B. : 1983, Astron. Astrophys. 117, 183. Reynolds, R. J.: 1976, Astrophys. J. 203, 151. Sandqvist, A. : 1976, Monthly Notices Roy. Astron. Soc. 177, 69 P. Srinivasan, M. , Pottasch, S. R. , Sahu, K. C. , Wesselius, P.R. , Desai, J.N. : 1987, submitted to Astron. Astrophys. Wallerstein, G. , Silk, J., Jenkins, E. B. : 1980, Astrophys. J., 240, 834. Zealey, W.J.: 1979, New Zealand J. Sci. 22, 549. The Proceedings of the ESO Workshop on
Sustainability Communications and Corporate Brand Associations

Executives are increasingly opting to undertake initiatives intended to benefit the natural environment (E), society (S), and/or corporate governance (G); however, the implications of the various messaging vehicles used to convey such corporate sustainability activities on the buying public’s perceptions about the company are not fully understood. This article addresses this knowledge gap by explicating how select paid, owned, and earned ESG communications can impact brand perceptions about the selling firm. Specifically, we advance research propositions grounded in the marketing communications literature regarding the impact of firm- and stakeholder-generated ESG communications on a set of cognitive, affective, and behavioral outcomes that can augment collective corporate brand associations. Furthermore, we describe interesting research opportunities regarding the synergy between firm-generated communications (FGC) and stakeholder-generated communications (SGC) in shaping buyers’ perceptions about the selling firm.