Miracle-dz/UniFAR-FTUs huggingface dataset:
Unlocking the Potential of Bilosomes and Modified Bilosomes: a Comprehensive Journey into Advanced Drug Delivery Trends

Vesicular drug delivery systems have revolutionized the pharmaceutical field, offering a promising path for achieving targeted and sustained drug delivery. The oral, transdermal, and ocular routes of administration offer optimal ease in attaining desired therapeutic outcomes. However, conventional treatment strategies are all plagued with several challenges, such as poor skin permeability, ocular barriers, and gastrointestinal (GIT) degradation leading to vesicular disruption with the release of the encapsulated drug before reaching the targeted site of action. In recent years, bilosomes-stabilized nanovesicles containing bile salts have received considerable attention due to their versatility and adaptability for diverse applications. These bilayered vesicles enhance the solubility of lipophilic drugs and improve formulation stability in the gastrointestinal tract. They exhibit ultra-deformable properties, improving stratum corneum permeability, making them ideal candidates for oral and transdermal drug delivery. In addition, bilosomes find utility in topical drug delivery, making them applicable for ocular administration. Over the past decade, extensive research has highlighted bilosomes’ potential as superior vesicular carriers surpassing liposomes and niosomes. Advances in this field have led to the development of modified bilosomes, such as probilosomes and surface-modified bilosomes, further enhancing their capabilities and therapeutic potential. Thus, the present review provides a comprehensive summary of bilosomes, modified bilosomes, surface modifications with their mechanism of action, formulation components, preparation methods, patents, and a wide array of recent pharmaceutical applications in oral, transdermal, and ocular drug delivery. The enhanced properties of bilosomes offer promising prospects for targeted and effective drug delivery, providing potential solutions for addressing various therapeutic challenges.
Ultra-sensitive CMOS image sensor capable of operating down to 200 ulx at 60 fps

— This paper presents a 10μm pixel pitch, front side illuminated (FSI), dual electronic rolling shutter (ERS) and global shutter (GS) image sensor with a fully depleted pinned photodiode (FDPD). At 950nm a quantum efficiency (QE) of 45% and a modulation transfer function (MTF) of 54%, Nyquist frequency, is demonstrated. The circuit is operated in a flexible way embedding low level digital processing for image quality improvement such as high dynamic range (HDR) and fixed pattern noise (FPN) correction.
Are Academically At-Risk College Students More Entitled Than Are Academically At-Risk College Students More Entitled Than Their Non-at-Risk Peers? Their Non-at-Risk Peers?

Academic Entitlement (AE) is a belief held by students that they deserve high grades in school despite a lack of effort put forth into their work (Chowning & Campbell, 2009). Although AE has become a major focus of conversation amongst higher education professionals, few studies have been published on this topic in relationship to student retention and success. The purpose of this study was to examine the relationship between academic performance and AE for two college student groups. Results included academically at-risk students scoring significantly higher on AE than the non-at-risk group, with AE being negatively correlated with GPA.
Pan Arab Journal of Rhinology Pan Arab Journal of Rhinology

Aim : We aimed to measure the levels of soluble programmed death-ligand 1 (sPD-L1) and soluble inducible cos-timulator ligand (sICOS-L) in patients with nasal polyps and to compare their levels between a group with allergic rhinitis (AR) with nasal polyps and another with allergic fungal rhinosinusitis (AFRS). The study also aimed to assess the relationship between their levels and disease severity. Patients and methods : The study included 35 patients admitted for endoscopic sinus surgery for nasal polyps, who were divided into 17 with AR and 18 with AFRS and 20 controls. Radiologic computed tomography (CT) score of Lund e Mackay was used to assess the severity of chronic rhinosinusitis. Complete blood cell count was done for all patients. Serum PD-L1 and ICOS-L levels were quanti ﬁ ed using enzyme-linked immunosorbent assay. Results : A signi ﬁ cant decrease was observed in sPD-L1 levels in both groups of patients compared with controls. Only patients with AFRS had a signi ﬁ cantly lower level of sICOS-L than controls and was lower than in AR patients. Only patients with AFRS showed positive correlations between sPD-L1 and the total CT score, and also between sICOS-L and both total CT score and eosinophil percentage. A positive correlation was detected between ICOS-L and PD-L1 levels. Conclusions : The present results suggest a potential protective role of sPD-L1 in AR and AFRS, and only of sICOS-L in AFRS. Thus, their manipulation represents a promising therapeutic approach to AR and AFRS. They also have the potential for future use as biomarkers for the assessment of AFRS severity. However, further studies are warranted to clarify their complex role in these types of allergies.
A STUDY ON CONFLICT MANAGEMENT USING BARON MODEL

: BarOn has proved emotional intelligence can bring conflict resolution in his paper Optimizing people. BarOn has also proved EQ can be increased and emotional intelligence can minimize conflict. In this paper we have proved each conflicting style can be related to specific BarOn competency, since all BarOn competencies have specific emotional and social intelligence skills, we combine emotional and social components with TKI. We examine the relationship between BarOn competencies and Thomas-kilmann conflict mode instrument. We have proved that the conflicting style of a person can be changed and EI can be increased using BarOn’s model, since BarOn has explained skills related to each competency and that skills can be improved so as to minimize conflict in the organization and effective running of the organization, retaining competitive edge with effective team bonding. This study is about relationship between baron model and a wider variety of human performance. Emotional and social intelligence mainly focuses on abilities. We also give new definitions of abilities in this paper.
PROOF COVER SHEET

Mercury (Hg) in tree wood has been overlooked, in part because concentrations are so low as to be below detection limits of some analytical methods, but it is potentially important to forest eco-10 system processes and budgets. We tested methods for the preparation and determination of Hg in tree wood by analy sing samples of four tree species at the Hubbard Brook Experimental Forest, New Hampshire, USA, using thermal decomposition, catalytic conversion, amalgamation and atomic absorption spectro-15 photometry (USEPA Method 7473). Samples that were freeze-dried or oven-dried at 65°C were suitable for determination of Hg, whereas oven-drying at 103 °C resulted in Hg losses, and air-drying resulted in Hg gains, presumably due to sorption from indoor air. Mean (±SE) concentrations of Hg tree bole wood 20 were 1.75 ± 0.14 ng g − 1 for American beech, 1.48 ± 0.23 ng g − 1 for sugar maple, 3.96 ± 0.19 ng g − 1 for red spruce and 4.59 ± 0.06 ng g − 1 for balsam ﬁ r. Based on these concentrations and estimates of wood biomass by species based on stand inventory, we estimated the Hg content of wood in the reference 25 watershed at Hubbard Brook to be 0.32 g ha − 1 , twice the size of the foliar Hg pool (0.15 g ha − 1 ). Mercury in wood deserves more attention and is feasible to measure using appropriate techniques.
UvA-DARE (Digital Academic Repository) Excitation-Inhibition Dynamics Regulate Activity Transmission Through the Perirhinal-Entorhinal Network

— The perirhinal (PER) – lateral entorhinal (LEC) network plays a pivotal role in the information transfer between the neocortex and the hippocampus. Anatomical studies have shown that the connectivity is organized bi-directionally: the super ﬁ cial layers consist of projections running from the neocortex via the PER-LEC network to the hippocampus while the deep layers form the output pathway back to the neocortex. Although these pathways are characterized anatomically, the functional organization of the super ﬁ cial and deep connections in the PER-LEC network remains to be revealed. We performed paired recordings of super ﬁ cial and deep layer principal neurons and found that a larger population of super ﬁ cial neurons responded with action potential ﬁ ring in response to super ﬁ cial cortical input, compared to the deep layer population. This suggested that the super ﬁ cial network can carry information from the cortex towards the hippocampus. The relation between the excitatory and inhibitory input onto the deep and super ﬁ cial principal neurons showed that the window of net excitability was larger in super ﬁ cial principal neurons. We performed paired recordings in super ﬁ cial layer principal neurons and parvalbumin (PV) expressing interneurons to address how this window of opportunity for spiking is affected in super ﬁ cial principal neurons. The PV interneuron population initiated inhibition at a very consistent timing with increasing stimulus intensity, whereas the excitation temporally shifted to ensure action potential ﬁ ring. These data indicate that super ﬁ cial principal neurons can transmit cortical synaptic input through the PER-LEC network because these neurons have a favorable window of opportunity for spiking in contrast to deep neurons. © 2019 The Author(s). Published by Elsevier
Di V erential e V ects of deﬁbrillation on systemic and cardiac sympathetic activity

Objective —To assess the e V ect of deﬁbril-lation shocks on cardiac and circulating catecholamines. Design —Prospective examination of myocardial catecholamine balance during dc shock by simultaneous determination of arterial and coronary sinus plasma concentrations. Internal countershocks (10– 34 J) were applied in 30 patients after initiation of ventricular ﬁbrillation for a routine implantable cardioverter deﬁbril-lator test. Another 10 patients were externally cardioverted (50–360 J) for atrial ﬁbrillation.
IDENTIFICATION OF ALTERED TUFF AND SUPERGENE ZONE AT FERDOWS AREA, IRAN PROSPECTING FOR POLYMETAL USING LANDSAT 8 AND ASTER SATELLITE IMAGES

Application of remote sensing in recent years, the exploration of mineral resources has been developed. Most satellite images applied in mineral exploration have capability to identify areas of alteration. Since a direct correlation between Polymetal alteration and mineralization in the area is the ideal expectation, identifying them with the help of satellite images, which accelerates the exploration and lowering the cost has high significance. There is an extensive alteration zone in the study area. Enhancement methods have been applied to satellite data available for this region to identify alteration zones, including the alteration of the area associated with Polymetal mineralization, the type of alteration is argillic. Therefore, the index of alteration minerals such as kaolinite, illite, montmorillonite, alunite and dickite, have been used to indentify the argillic alteration zone. Chlorite and epidote were minerals used for identification of propylitic alteration.
Obesitas dan Obesitas Sentral pada Masyarakat Usia Dewasa di Daerah Perkotaan Indonesia Obesity and Central Obesity in Indonesian Urban Communities

Obesity is a problem in various parts of the world where its prevalence is increasing rapidly, both in developed and developing countries Obesity can occur because of an imbalance between the energy from the food that comes in, which is greater than the energy used by the body. This study aimed to see the characteristics of obesity and central obesity in adult society in urban areas of Indonesia. This study used a cross-sectional study, by analyzing advanced data on Basic Health Research (Riskesdas) in the biomedical field. The results of this study indicated that in general obesity and central obesity increase with age, with the highest prevalence being at the age of 40-59 years. Both obesity and central obesity were more prevalent in female subjects. Obesity and central obesity were also more common among subjects who graduated from high school and who work as housewives. Subjects of obesity and central obesity experienced more abnormalities in biomedical examination than those with normal BMI and abdominal circumference. For this reason, it is advisable to maintain a normal BMI and abdominal circumference, especially for adults. This study proves that there are significant differences in biomedical examination in those who are obese and not obese.
Geospatial Filter and Reﬁne Computations on NVidia Blueﬁeld Data Processing Units (DPU)

In this poster, we will show how to leverage NVidia’s Blue-ﬁeld Data Processing Unit (DPU) in geospatial systems. Existing work in literature has explored DPUs in the context of machine learning, compression and MPI acceleration. We show our designs on how to integrate DPUs into existing high performance geospatial systems like MPI-GIS. The workﬂow of a typical spatial computing workload consists of two phases - ﬁlter and reﬁne. First we used DPU as a target to oﬄoad spatial computations from the host CPU. We show the performance improvements due to oﬄoad. Next we used DPU for network I/O processing. In network I/O case, the query data ﬁrst comes to DPU for ﬁltering and then the query goes to CPU for reﬁnement. DPU-based ﬁlter and re-ﬁne system can be useful in other domains like Physics where an FPGA is used to perform the ﬁlter to handle Big Data. We used Blueﬁeld-2 and Blueﬁeld-3 in our experiments. For scalability study, we have used up to 16 DPUs.
Risk of Complications in Patients Undergoing Diagnostic Cardiovascular Catheterization at Radial versus Femoral Vascular Access Sites

: Diagnostic cardiac catheterization is among the most commonly performed procedure. There are a number of potential complications from cardiac catheterization. The complications can be minor as discomfort at the site of catheterization to major ones like death . Aim of the study: Assess risk of complications in patients undergoing diagnostic cardiovascular catheterization at radial versus femoral vascular access sites. Setting: The study was conducted at the. The International Cardiac Center Hospital (ICC). Alexandria. Subjects: A convenience sample of 180 adult patients. Tools: One tool was used in this study: Radial versus Femoral Access Site Assessment Sheet. Results: The study revealed that females exceeded males in the radial groups, 53.4%, 46.6% respectively 56.8% of radial group patients and 45.7% of femoral group patients had read and write. Diabetic patients represented 26.1% of the patients radial group, while chronic obstructive pulmonary disease patients represented 22.8% of the femoral group. More nearly two fifth of the studied patients 38.1% were post myocardial infarction, compared to 45.5% of them in the radial group who had unstable angina. cases with complication was (30.7%) in radial group and was (51.1%) in femoral group, while cases without complication was (69.3%) and (48.9%). There was statistical significant difference between two studied groups regarding incidence of complications (P < 0.05). Conclusion: The radial approach would ensure better patient safety, satisfaction and comfort which would help reduce the patients length of stay and increase patients treated with timely discharges. Recommendations: Develop and apply an educational programs should be implemented to each patient about how to care for access site after coronary angiography.
A 1.2Mp indirect-ToF sensor with on-chip ISP for low-power and self-optimization

— We propose an i-ToF to improve power consumption and motion artifact. AR/VR and Robot devices that require depth information when implementing applications have limitations when using i-ToF due to limited power and moving motion characteristics. In particular, the increase in the amount of AP operation according to the implementation of high resolution and the limitation of latency time due to multi-frame operation occur. The proposed sensor has an embedded depth processor to process depth calculation inside the sensor and enables low-power realization by using a 28nm process. In addition, motion artifact was reduced by operating at 250FPS readout speed. As a result, 30FPS depth output can be output from the sensor itself, and power consumption is reduced by 90%.
Flexible Spectrally-Scanning Snapshot Multispectral Imaging On Dual-Tap Coded-Exposure-Pixel CMOS Image Sensors

— We present a method of spectrally-scanning snapshot multispectral imaging (MSI) that employs a dual-tap coded-exposure-pixel (CEP) CMOS image sensor. A frame exposure time is divided into N subexposures. During each subexposure, an arbitrarily programmable exposure code is sent to each pixel to control the integration of the photogenerated charge into one of the two taps. We employ the data-memory pixel (DMP) architecture for the CEP, which achieves the smallest pixel size or all CEP sensors. Five unique-wavelength LEDs are sequentially turned on, synchronously with five unique 2x2-pixel code tiles, and submitted to the sensor over five subexposures. The sorted photogenerated charges are read out, and five images at the five wavelengths are subsequently extracted by demultiplexing. The number of wavelengths is flexible and can be easily extended using a larger pixel tile. As a result, spectra for a scene are captured at 5 wavelengths in the visible light and NIR spectrum in a single frame, at 30 frames per second, without using a color filter array.
Surface Energy Balance model for high-altitude glacial system at 19°N on Glaciar Norte, Mexico

The glaciers of Mexico are very small ice bodies located on top of the highest mountains of Mexico. They represent a natural gauge for the climatic changes at the 19oN latitude where no other ice bodies are located around the world. Glaciar Norte glacier on Citlaltepetl Volcano, Mexico, has been retreating in a huge scale, just like other glaciers close to the tropics. Following the current trend of the small glaciers around the world, this glacier will probably disappear before mid-century and with its disappearance an important climatic gauge at this latitude will be gone. Therefore, it is important to identify the factors influencing the retreat and eventual demise of the glaciers. This study focuses on the analysis of the energy fluxes of Glaciar Norte’s surface on the northern flank of Citlaltepetl Volcano, Mexico. From this, it was calculated the energy balance for a single point on the glacier surface. Here, the glacio-meteorological study is described using data from automatic weather stations installed at >5100 masl with the energy balance model developed from this data. The results suggest that net radiation is the main component responsible for the retreat of Mexican glaciers since this parameter controls the energy balance variability. This situation was compared to the energy balance regime present on other tropical and mid-latitude glaciers and it was possible to establish a first approximation of the energy balance regime on glaciers near 19N latitude based on energy balance variability.
Comparative study between Transpedicular Screws Alone versus Comparative study between Transpedicular Screws Alone versus Transpedicular Screws with Intervertebral cage in Management of Transpedicular Screws with Intervertebral cage in Management of Recurrent Lumbar Disc Prolapse Recurrent Lumbar Di

Background : The most frequent surgical technique for people with low back and leg discomfort is lumbar disc surgery. The persistence or recurrence of symptoms arises as a prominent consequence of primary surgery, despite the enhanced success of lumbar disc surgery with many new technological and surgical procedures. Aim : In order to manage recurrent lumbar disc prolapse, this research compares the surgical results of transpedicular screws alone or in conjunction with posterior interbody fusion (PLIF) polyetheretherketone (PEEK) cage. Patients and methods : This is a prospective and retrospective comparative research of 20 patients suffering from recurrent lumbar disc prolapse, Patients are included randomly in either of the two groups, each group includes 10 patients, Group A: included patients who had interbody fusion added to the transpedicular screw, Group B: included patients who were subjected to transpedicular screws alone. Results : The study ' s ﬁ ndings demonstrated that mean ± SD of Pain (VAS score) preoperatively was in group A 7.79 ± 1.41, and VAS score after 3 months postoperatively was 1.25 ± 0.576, and in group B was 7.59 ± 1.64, and the VAS score after 3 months postoperatively was 1.62 ± 0.638, there was a very statistically substantial variation between pre and postoperative regarding pain ( P < 0.001), the majority of case had no complications. Conclusion : Posterior Lumbar Interbody Fusion Combined with Transpedicular Screws is more technically feasible and enhanced reduced back pain and radicular pain more than Transpedicular Screws alone and it can be the best option for management of recurrent lumbar disc prolapse.
Correlations between DCR and PDP of SPAD integrated in a 28 nm FD-SOI CMOS Technology

— This article presents an experimental study of the Dark Count Rate (DCR) and the Photon Detection Probability (PDP) of Single-Photon Avalanche Diodes (SPAD) implemented in 28nm Fully Depleted Silicon-On-Insulator (FD-SOI) CMOS technology and proposes a TCAD simulation study correlating the experimental DCR et PDP results. The measurements and the TCAD simulations show a dependence of DCR and PDP with the amount of the Shallow Trench Isolation (STI) oxide in the active zone and the alignment of the peripheral STI with the SPAD junction. SPADs featuring more STI oxide in the active zone (including the peripheral STI) tend to present higher DCR and PDP. The TCAD simulations show higher values of Avalanche Triggering Probability (ATP) explaining higher PDP obtained with SPAD featuring more STI oxide in the active zone. The defects located at the interface of P-Well / STI and related to the doping steps are potentially the one of the main sources of the higher DCR of the aforementioned SPAD.