Miracle-dz/UniFAR-FTUs huggingface dataset:
15 International Strategic Management Conference THE STRATEGIC VIEW OF PORT INVESTMENT DECISIONS

Maritime transport is most preferred transportation mode in global trade and ports are strategy model points along global supply chains due to their integral part role in maritime transportation. Efficiency and effectiveness in the port industry can create a competitive advantage to port operators and supply chains they are in part as well. In order to ensure the sustainability of ports, environmental, economic and social components of port investments must be taken into account. Thus, investment decisions have strategic importance to gain and sustain a competitive advantage, which requires an analysis of port performance indicators. Investment decisions also necessary to respond to the requirements of the industry at a level above the average, while the wrong prediction can be caused idle capacity, loosed capital and missed opportunity costs. This study aimed to create an effective decision-making process. According to this aim, SWOT, AHP and Stepwise Regression analyses are combined. Firstly, investment decision criteria were determined by SWOT analysis, and AHP technique is used for weighting the criteria. Findings of these two steps used as the inputs of investment decision. Finally, a statistical model developed to help decision makers to decide which type of investment must be made by stepwise regression analysis.
Cytotoxic Mechanisms Gut-Mucosal Sites: Activation Status and Lymphocytes in Peyer's Patches and Distal Activation of Antigen-Specific T Reovirus Serotype 1/Strain Lang-Stimulated

Intraduodenal priming of mice with reovirus serotype 1/strain Lang (reovirus 1/L) stimulates gut lymphocytes and generates precursor and effector CTLs. Our earlier studies demonstrated that germinal center and T cell Ag (GCT) is a marker which identiﬁes reovirus 1/L-speciﬁc precursor CTL and effector CTL in Peyer’s patches (PP) of reovirus 1/L-inoculated mice. In this study, we characterized the expression of the activation markers, GCT and CD11c, on reovirus 1/L-stimulated gut lymphocytes and the effector mechanisms involved in reovirus 1/L-speciﬁc cytotoxicity. We found that intraduodenal reovirus 1/L inoculation of mice induced the expression of both GCT and CD11c on PP lymphocytes (PPL), intraepithelial lymphocytes (IEL), and lamina propria lymphocytes (LPL), and these activated cells expressed Fas ligand (FasL). The majority of the GCT (cid:1) CD11c (cid:1) IEL and LPL expressed a phenotype, TCR (cid:2)(cid:3) (cid:1) Thy-1 (cid:1) CD8 (cid:1) similar to that expressed on reovirus 1/L-stimulated PPL. However, splenic lymphocytes expressed GCT but not CD11c after stimulation with reovirus 1/L. Perforin, Fas-FasL, and TRAIL pathways were found to be involved in PPL, IEL, and LPL cytotoxic activity against reovirus 1/L-infected targets. In PPL, perforin and Fas-FasL pathways were more effective than TRAIL. In IEL, all three cytotoxic mechanisms were equally as effective. However, LPL prefer Fas-FasL and TRAIL over perforin. Further, we demonstrated the preferential migration of GCT (cid:1) PPL to the intraepithelial compartment and the lamina propria. These results suggest that GCT and CD11c can be used as activation markers for gut lymphocytes and CD11c can also be used to differentiate between activated gut and systemic lymphocytes. The Journal of Immunology, 2005, 174: 3580–3589. incubation of target cells in 100 (cid:5) l of 2% Triton X-100 and spontaneous LDH release was determined by addition of medium only. The percentage of speciﬁc LDH released was calculated as percent-speciﬁc cytotoxicity (cid:5) (experi- mental release (cid:4) effector spontaneous release (cid:4) target spontaneous re-lease)/(maximum target release (cid:4) spontaneous target release). Results are expressed as the mean percent-speciﬁc cytotoxicity (cid:6) SD. the
Buffering blood pressure fluctuations by respiratory sinus arrhythmia may in fact enhance them: a theoretical analysis

Using a three-compartment model of blood pressure dynamics, we analyze theoretically the short term cardiovascular variability: how the respiratory-related blood pressure fluctuations are buffered by appropriate heart rate changes: i.e. the respiratory sinus arrhythmia. The buffering is shown to be crucially dependent on the time delay between the stimulus (such as e.g. the inspiration onset) and the application of the control (the moment in time when the efferent response is delivered to the heart). This theoretical analysis shows that the buffering mechanism is effective only in the upright position of the body. It explains a paradoxical effect of enhancement of the blood pressure fluctuations by an ineffective control. Such a phenomenon was observed experimentally. Using the basis of the model, we discuss the blood pressure variability and heart rate variability under such clinical conditions as the states of expressed adrenergic drive and the tilt-test during the parasympathetic blockade or fixed rate atrial pacing. From the results of the variability analysis we draw a conclusion that the control of blood pressure in the HF band does not directly obtain the arterial baroreceptor input. We also discuss methodological issues of baroreflex sensitivity and sympathovagal balance assessment.
the MHC CIITA Identification of a Nuclear Export Sequence

Initiation of an immune response through expression of MHC class II and related genes is under the control of the CIITA. Normally found in both the cytoplasm and nucleus, CIITA is tightly controlled by a variety of posttranslational modiﬁcations as well as interactions with other nuclear and cytoplasmic factors, whereas disruption of this dual subcellular localization impairs CIITA functioning and expression of target genes. Although CIITA has well-deﬁned domains necessary for its nuclear import, the region responsible for the translocation of CIITA from the nucleus has not been characterized. In this study, we identify a leucine-rich motif at residues 717–724 that bears strong homology to known nuclear export sequence (NES) domains. Mutation of this region renders CIITA insensitive to treatment with leptomycin B, an inhibitor of nuclear export, whereas fusion of this domain to a heterologous GFP is sufﬁcient to induce its export to the cytoplasm or cause its retention in the nucleus following leptomycin B treatment. Point mutations of speciﬁc leucine residues within the NES disrupt the normal subcellular distribution of the full-length CIITA, impair its ability to interact with the nuclear export factor CRM1, and enhance CIITA-induced gene expression from an MHC class II gene promoter. IFN- g stimulation of class II genes is further enhanced by inhibiting the nuclear export of endogenous CIITA. Collectively, these data demonstrate the ﬁrst identiﬁcation of a speciﬁc NES within CIITA and place it among the other protein domains that contribute to the posttranslational regulation of CIITA activity. The Journal of Immunology , 2015, 194: 000–000.
Security Analysis on Cloud Data Search by using one to many Order Preserving Encryption

Cloud computing economically enables the paradigm of data service out-sourcing. However, to protect data privacy, sensitive cloud data have to be encrypted before outsourced to the commercial public cloud, which makes effective data utilization service a very challenging task . For ranked search in encrypted cloud data, order preserving encryption (OPE) is an efficient tool to encrypt relevance scores of the inverted index. When using deterministic OPE, the cipher texts will reveal the distribution of relevance scores. Therefore it is called one-to-many OPE, for applications of searchable encryption, which can flatten the distribution of the plain texts. We proposed a differential attack on one-to-many OPE by exploiting the differences of the ordered cipher texts. The experimental results show that the cloud server can get a good estimate of the distribution of relevance scores by a differential attack. Thus sensitive data have to be encrypted before being outsourced to a commercial public cloud. By using recurrence score we can retrieve the file from cloud.
T2HSOM: Understanding the Lexicon by Simulating Memory Processes for Serial Order

Over the last several years, both theoretical and empirical approaches to lexical knowledge and encoding have prompted a radical reappraisal of the traditional dichotomy between lexicon and grammar. The lexicon is not simply a large waste basket of exceptions and sub-regularities, but a dynamic, possibly redundant repository of linguistic knowledge whose principles of relational organization are the driving force of productive generalizations. In this paper, we overview a few models of dynamic lexical organization based on neural network architectures that are purported to meet this challenging view. In particular, we illustrate a novel family of Kohonen self-organizing maps (T2HSOMs) that have the potential of simulating competitive storage of symbolic time series while exhibiting interesting properties of morphological organization and generalization. The model, tested on training samples of as morphologically diverse languages as Italian, German and Arabic, shows sensitivity to manifold types of morphological structure and can be used to bootstrap morphological knowledge in an unsupervised way.
Hospital Volume and Selection of Valve Type in Older Patients Undergoing Aortic Valve Replacement Surgery in the United States and Outcomes

Background —Hospital volume has been linked to quality of care. The relation between hospital volume and recommended use of bioprosthetic valves in older patients undergoing aortic valve replacement (AVR) is unknown. Methods and Results —We identified 80 470 patients aged (cid:1) 65 years undergoing isolated AVR (with or without bypass surgery) in 1045 US hospitals during 1999–2001 from Medicare Part A files. International Classification of Diseases, Ninth Revision, Clinical Modification codes were used to identify patients undergoing bioprosthetic valve (35.21) or mechanical valve (35.22) AVR. The sample was categorized into deciles on the basis of the valve surgery volume of the hospital. Generalized estimating equations determined the relative risk of receiving a bioprosthetic valve in different volume deciles, with adjustment for age, gender, race, comorbidity, and other factors. Bioprosthetic valve use increased ( P (cid:1) 0.001) from 44% in 1999 to 52% in 2001 and with age (from 36% in patients aged 65 to 69 years to 60% in patients aged (cid:1) 90 years). Rates were directly related ( P (cid:1) 0.001) to volume, rising from 28% in the 1st decile to 68% in the 10th decile. With the use of generalized estimating equations, the relative risk of bioprosthetic valve use, relative to the 1st decile, progressively increased from 1.2 (95% CI, 1.1 to 1.4) in the 2nd decile to 2.3 (95% CI, 1.9 to 2.7) in the 10th decile. Conclusions —Hospital volume was a strong predictor of bioprosthetic valve use in older patients undergoing AVR. The lower use of bioprosthetic valves in low-volume hospitals is at odds with recent guidelines recommending bioprosthetic valves in patients aged (cid:1) 65 years. These findings further support the use of volume as a marker of hospital quality.
Tra2 (cid:1) As a Novel Mediator of Vascular Smooth Muscle Diversification

—Transformer splicing regulatory proteins determine the sexually dimorphic traits of Drosophila . The role of the vertebrate homologs of Tra-2 in phenotypic specification is undefined. We are using the alternative splicing of the MYPT1 E23 exon as a model for the study of smooth muscle diversification into fast and slow contractile phenotypes. Tra2 (cid:1) mRNA and protein is expressed at up to 10-fold higher levels in fast smooth muscle tissues such as the rat portal vein and small mesenteric artery, in which E23 is spliced, as compared to the slow smooth muscle tissues of the large arteries and veins, in which E23 is skipped. Tra2 (cid:1) is upregulated up to 10-fold concordant with the initiation of E23 splicing as the rat portal vein and avian gizzard implement the fast program of gene expression in the perinatal period. In disease models such as portal hypertension and mesenteric artery high/low flow, the portal vein and first order mesenteric artery dynamically downregulate Tra2 (cid:1) concordant with a shift to E23 skipping and the slow program of gene expression. Tra2 (cid:1) binds to a highly conserved sequence within E23 and transactivates its splicing in vitro and in vivo; this is abolished with mutation or deletion of this sequence. RNA interference–mediated knockdown of Tra2 (cid:1) markedly reduces E23 splicing. We propose that Tra2 (cid:1) has been conserved through evolution and redeployed for the specification of the fast smooth muscle phenotype and may serve as a novel nodal point for the investigation of this process in developmental and disease models. ( Circ Res . 2008;103:485-492.)
OPTH_A_336865 4153..4162

1Ophthalmology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain; 2Aiken Prevencción y Cirugía Ocular, Valencia, Spain; 3Department of Ophthalmology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; 4Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel Purpose: To determine the impact of different baseline clinical characteristics on the improvement in best corrected visual acuity (BCVA) in patients with diabetic macular edema (DME) who underwent the intravitreal dexamethasone implant (DEX) Ozurdex. Methods: This was a single center retrospective study conducted on patients with DME, either naïve or previously treated, who were treated with one or more DEX and had a followup of at least 6 months. The main outcome measure was the proportion of DEX achieving an improvement ≥15 letters in BCVA. Results: The study analyzed 192 DEX implants administered to 97 eyes (65 patients). Among the 192 DEX analyzed, 57 (29.7%) implants achieved a BCVA improvement ≥15 letters (ETDRS) from baseline, with a mean time for achieving such improvement of 89.2 (39.7) days. Eyes who received an additional DEX and those with a duration of DME < 6 months had a greater probability of achieving a BCVA improvement ≥15 letters (odds-ratio: 2.55, p = 0.0028 and odds-ratio: 1.93, p = 0.0434). The mean (standard deviation) change in BCVA from baseline was 7.5 (14.5) letters, p < 0.0001. The mean change in central macular thickness (CMT) from baseline was −128.0 (151.0) μm, p < 0.0001. The mean number of DEX implanted was 1.9 (0.8). Four (2.1%) DEX experienced an intraocular pressure increased ≥10 mm Hg; all the cases were successfully managed with topical antiglaucoma medication. Conclusion: The results of this study confirmed previous evidence suggesting that DEX is effective for improving BCVA and CMT in patients with DME.
Double Solution with Chaos: Dynamic Redundance and Causal Wave-Particle Duality

A system of two interacting, physically real, initially homogeneous fields is considered as the simplest basis for the world construction in which one of them, a protofield of electromagnetic nature, is attracted to another protofield, or medium, responsible for the eventually emerging gravitational effects. The interaction process is analysed within the generalised effective (optical) potential method in which we avoid any usual perturbative reduction. It then appears that for generic system parameters the protofields, instead of simply "falling" one onto another and forming a fixed "bound state", are engaged in a self-sustained process of nonlinear pulsation, or "quantum beat", consisting in unceasing cycles of self-amplified auto-squeeze, or "collapse" ("reduction"), of a portion of the extended protofields to a small volume followed by the inverse phase of extension. Centres of consecutive reductions form the physical "points" of thus emerging, intrinsically discrete space, and each of them is "selected" by the system in a causally random fashion among many equally possible versions (or "realisations"). This is a manifestation of the dynamic redundance forming the unified basis of dynamically complex (chaotic) behaviour of any real system with interaction (physics/9806002). The sequence of reduction events constitutes the elementary physical "clock" of the world providing it with the unceasing, intrinsically irreversible time flow. The complex-dynamical quantum beat process in the system of two interacting protofields is observed as the massive elementary particle (like the electron) which naturally possesses the property of physically real wave-particle duality completing the double solution concept of Louis de Broglie (see also quant-ph/9902016, gr-qc/9906077).
Patterns of regional lymph node failure of locally advanced hypopharynx squamous cell carcinoma after first-line treatment with surgery and/or intensity-modulated radiotherapy

Purpose : To identify the spatial patterns of regional lymph node failure of locally advanced hypopharynx squamous cell carcinoma (SCC) after first-line treatment with surgery and/or intensity-modulated radiotherapy (IMRT). Methods : We retrospectively analyzed 123 patients of the hypopharynx SCC consecutively treated with radical surgical resection and/or IMRT. Results : Median PFS were 13 months (95% CI 6.4-19.6 months), and 11 months (95% CI 9.1-12.9 months) for patients receiving surgery and IMRT, respectively. The cervical lymph node failure was accounted for 32.5% of patients, with involved ipsilateral neck level II in 22 patients (55.0%), III in 12 patients (30.0%), IV in 2 patients (5%), VIb and VII both in 6 patients (5.0%), furthermore, involved contralateral neck level II in 7 patients (17.5%), III in 3 patients (7.5%). The commonly failure levels were the II (15.2%), III (8.7%), VIb (8.7%), and VII (10.9%) for surgery. The lymph node recurrence and persistent disease at levels II (24.7%) and III (13.0%) remained the major cause of failure following curative intent of IMRT. Conclusions: Whatever the treatment modality, levels II and III were most commonly failure regions. Because of high rate of node failure of level VIb and VII for patients receiving surgery, post-operative radiation should included of these territories in locally advanced hypopharynx SCC.
THE HISTO-PROTECTIVE EFFECTS OF THE ROOT EXTRACTS OF SALACIA NITIDA BENTH ON TISSUES OF ALLOXAN INDUCED DIABETIC RATS

Aim : This study was carried out to determine the histo-protective and regenerative effects seen on the liver, tissue and pancreas in alloxan induced diabetic rats after administration of Salacia nitida Benth. Study design : Experimental Animal Study. Place and Duration of Study: Department of Pharmacology, University of Port Harcourt, Rivers State from July 2016 to February 2017. Methodology : This study was carried out to investigate the potential tissue protective effects of the root extracts of Salacia nitida Benth in alloxan induced diabetic rats. Fifty five adult Wistar rats randomly divided into eleven groups of five rats each. The method of successive extraction was used. The anti-diabetic study was evaluated in twenty-one days, comprising of two phases: induction phase and treatment phase. On day 21 of treatment with S. nitida extracts, the animals were sacrificed and histological analysis carried out. Results : the histolgical examination of the kidney, liver and pancreas of alloxan induced diabetic rats indicated a protective effect after administration of the dicholoromethane extract with less diabetes induced degenerative damage seen. Conclusion : the dicholoromethane extract showed histoprotective effects as seen with the regeneration of damaged cells on exposure of the rats to alloxan.
The Development of Learning Tools Using Software in Informatics Engineering Department

– Software learning tools orient students to think critically about learning actively. The success of the application of this software learning tools for Algorithm and Programming materials depends on the role of lecturers, readiness, strategy, techniques and learning methods used as a medium of learning addressed to STMIK Informatics Engineering students in Makassar. Factors that support the implementation of learning in the classroom are planning of applying learning tools that are used, namely learning tools software. It includes semester implementation plan, lecturing unit, teaching materials, and student activity sheet. Therefore, the formulation of the problem in this study is how is the level of validity of learning tools software developed by the Department of Informatics Engineering? The purpose of this study is to describe the level of validity of the developed learning tools software in the Department of Informatics Engineering. The validity was obtained based on the assessment of the media expert's validator and the material expert on instructional tools made by the researcher including learning device software, teaching materials, semester implementation plan, lecturing unit, the student activity sheet and learning outcome test.
Wavelet Coherence Analysis of Change Blindness

Change blindness is the incapability of the brain to detect substantial visual changes in the presence of other visual interruption. The objectives of this study are to examine the EEG (Electroencephalographic) based changes in functional connectivity of the brain due to the change blindness. The functional connectivity was estimated using the wavelet-based MSC (Magnitude Square Coherence) function of ERPs (Event Related Potentials). The ERPs of 30 subjects were used and were recorded using the visual attention experiment in which subjects were instructed to detect changes in visual stimulus presented before them through the computer monitor. The two-way ANOVA statistical test revealed significant increase in both gamma and theta band MSCs, and significant decrease in beta band MSC for change detection trials. These findings imply that change blindness might be associated to the lack of functional connectivity in gamma and theta bands and increase of functional connectivity in beta band. Since gamma, theta, and beta frequency bands reflect different functions of cognitive process such as maintenance, encoding, retrieval, and matching and work load of VSTM (Visual Short Term Memory), the change in functional connectivity might be correlated to these cognitive processes during change blindness.
(2017). Quenching the spark: Termination of CICR in the sub-microscopic space of the dyad. Journal of General Physiology , (10), 837-845.

Summary. Many mechanisms have been proposed for the termination of regenerative calcium-induced calcium release (CICR). Robust termination of CICR by ‘induction decay’ is made possible by significant local depletion of the sarcoplasmic reticulum (albeit underestimated in imaging experiments) decreasing RyR (re)activation.
(2020). Ricardo Flies Ryanair: Strategic Human Resource Management and Competitive Advantage in a Single European Aviation Market (SEAM).

How and why are some firms, such as Ryanair, able to consistently record industry ‐ leading profitability that sustains a competitive advantage over their rivals? Human resource management (HRM) plays a critical role in four widely recognised profit ‐ generating mechanisms, albeit not always in ways predicted by mainstream strategic HRM. Studies of HRM → performance grounded in the resource ‐ based view of the firm invariably focus on the human resources already controlled by the firm—specifically, resources that are rare, inimitable, non ‐ substitutable and can be exploited through organisation—rather than strategic factor markets where firms acquire their human resources. In doing so, these studies overlook the industrial relations and wider institutional context that might variously promote, permit or preclude particular HR policies and practices. It is only when different profit ‐ generating mechanisms, either in isolation or combination, are activated under the auspicious conditions of a particular time and place that HRM contributes to sustained competitive advantage.