Miracle-dz/UniFAR-FTUs huggingface dataset:
How are experiences and acceptability of child maltreatment related to resilience and posttraumatic growth: a cross cultural study

ABSTRACT Background: Post-traumatic growth (PTG) and resilience, regarded as positive psychological change following a traumatic experience, are under-researched across cultures in people exposed to child maltreatment (CM). Objective: We investigated how experiences and the perceived acceptability of CM are related to resilience and PTG in countries with different cultures, living standards, and gross national income. Method: A total of 478 adults from Cameroon (n = 111), Canada (n = 137), Japan (n = 108), and Germany (n = 122) completed an online survey with self-reported questionnaires, including the Brief Resilience Scale and the Post Traumatic Growth Inventory-Short Form. Results: Across countries, self-reported male gender and age were positively associated with resilience, while experiences of physical abuse and emotional maltreatment were negatively associated with resilience. Experiences of emotional maltreatment were positively associated with PTG. Higher levels of PTG and resilience were found amongst Cameroonian participants as compared to other countries. Conclusion: Our results suggest that positive changes following CM can vary significantly across cultures and that experiences of specific CM subtypes, but not the perceived acceptability of CM, may be important for a deeper understanding of how individuals overcome trauma and develop salutogenic outcomes. Our findings may inform CM intervention programmes for an enhanced cultural sensitivity. HIGHLIGHTS Across the four countries (Canada, Cameroon, Germany, Japan), more experiences of physical abuse and emotional maltreatment were associated with lower resilience; more experiences of emotional maltreatment were associated with greater post-traumatic growth. Higher levels of post-traumatic growth and resilience were found in Cameroon as compared to other countries. Positive changes following child maltreatment vary across cultures and experiences of specific child maltreatment subtypes, but the perceived acceptability of child maltreatment did not exert an influence on salutogenic post-traumatic outcomes.
Modeling late Paleozoic glaciation

Late Paleozoic glaciation on Gondwana is associated with changes in geography, solar luminosity, and estimated CO{sub 2} levels. To assess the relative importance of these boundary conditions, the authors conducted a suite of climate model simulations for the periods before, during, and after peak mid-Carboniferous ({approximately}300 Ma) glaciation (340, 300, and 255 and 225 Ma, respectively). Orbital insolation values favorable for glaciation and interglaciation were used for each time interval. Results indicate that changes in geography cause significant changes in snow area, but the temporal trend is not consistent with the geologic record for glaciation. Combined CO{sub 2}-plus-geography changes yield the best agreement with observations. In addition, interglacial orbital configurations result in almost ice-free conditions for the glacial interval at 300 Ma, at a time of low CO{sub 2}. The large simulated glacial-interglacial snowline fluctuations for Permian-Carboniferous time may explain cyclothem fluctuations at these times. Overall, results support the importance of the CO{sub 2} paradigm, but also indicate that a fuller understanding of past climate change requires consideration of paleogeographic, luminosity, and orbital insolation changes.
Diverse associations observed between pregnancy complications and RBC or plasma folates determined by an in-house developed LC-MS/MS method

Abstract Background As folates are essential for embryonic development and growth, it is necessary to accurately determine the levels of folates in plasma and red blood cells (RBCs) for clinical intervention. The aims of this study were to develop and validate a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantitation of folates in plasma and RBCs and to examine the association between plasma and RBC folate concentrations and gestational diabetes mellitus (GDM), gestational hypertension (GH) and preeclampsia (PE). Methods With the in-house developed LC-MS/MS, a retrospective cross-sectional study was conducted. The healthy pregnant women of first- (n = 147), second- (n = 84) and third-trimester (n = 141) or the women diagnosed with GDM (n = 84), GH (n = 58) or PE (n = 23), that were aged between 22 and 46 years old and registered at our institute, were subjected for measurement of folic acid (FA) and 5-methyltetrahydrofolate (5-MTHF), followed by appropriate statistical association analysis. Results The assay for simultaneous quantitation of FA and 5-MTHF in plasma and RBCs was linear, stable, with imprecision less than 15% and recoveries within ±10%. The lower limits of quantification for FA and 5-MTHF measurement in whole blood were 0.57 and 1.09 nmol/L, and in plasma were 0.5 and 1 nmol/L, respectively. In the association analysis, the patients with lower RBC folate level (<906 nmol/L) presented higher risks of PE development (OR 4.861 [95% CI 1.411–16.505]) by logistic regression and restricted cubic spline (RCS) regression in a nonlinear fashion. In addition, higher level of plasma folates in pregnancy was significantly associated with GH risk but may be protective for the development of GDM. Conclusions The in-house developed LC-MS/MS method for folates and metabolites in plasma or RBC showed satisfactory analytical performance for clinical application. Further, the levels of folates and metabolites were diversely associated with GDM, GH and PE development.
Distribució i grau d’invasió de la formiga argentina (Linepithema humile Mayr) (Hymenoptera: Formicidae) al Parc Natural de s’Albufera des Grau, Menorca (Illes Balears)

The Argentine ant is an exotic invasive species present in all the Mediterranean and subtropical ecosystems of the world. It is closely associated to urban and human-disturbed areas, even though it can also invade natural areas causing a strong negative effect in the biodiversity of the invaded area. In Menorca, the fist record of its presence was in 1976. In 2004 it was detected for the first time invading a natural area in the island, the s’Albufera des Grau Natural Park. The aim of this work is to determine both the distribution and degree of invasion of this species into the Park. To that effect, we sampled a total of 97 plots of 1 ha at 8 different areas across the Park. Of these, only 15 resulted invaded by the Argentine ant with different degrees of invasion. Additionally, we also detected 4 forefronts of invasion. Both the presence and degree of invasion into the s’Albufera des Grau Natural Park seems to be related to four factors: 1) degree of canopy cover, 2) proximity to urban or certain urban development areas, 3) degree of anthropic frequentness and 4) proximity to humid areas. The results obtained in this study allow getting basic information to elaborate further research about the real effects of the invasion in the biodiversity of the area
The Dynamics of Land Use Land Cover Change: Using Geospatial Techniques to Promote Sustainable Urban Development in Ilorin Metropolis, Nigeria

Land change dynamics was studied and analyzed across the plains of Metropolitan Ilorin between 1986 and 2010. A statistical sampling design, Landsat satellite data and Geographical Information System tools were used to efficiently identify patterns of land conversion. Variability of change ranged from approximately 2 percent to greater than 50 percent, and progressed at an uneven pace. Indicative of the changes is a sequence of agricultural expansion before 1986 followed by widespread conversion to built up area by 2000 and beyond. Pattern and magnitude of conversions influenced by contextual conditions of land quality, population increase, plus economic and policy drivers. The sporadic expansion of settlements, especially the built up areas in and around the study area, resulted in rapid diminishing and conversion of other land cover types to more built up environment and thus aaccentuating urban agglomeration of Ilorin. It is recommended that various Government regulatory authorities embark on careful urban planning by strickly allocating land for various designated purposes and ensure continous monitoring of physical developments so as to safeguard distortions to the urban environment of Ilorin.
Global Heating Threatens the `I`iwi (Vestiaria coccinea), Currently a Common Bird of Upper Elevation Forests in Hawaii

The `I`iwi is one of 17 surviving Hawaiian honeycreepers (Fringillidae: Drepanidinae) of 37 species known historically and 55 extant prior to human arrival on Hawaii (Pratt 2009). Its closest relative is the extinct Hawaii Mamo (Drepanis pacifica) (Pratt 2005). Disease and habitat loss are primary reasons for the decline of Hawaiian honeycreepers and other native forest birds. Extinctions continue to this day, with the most recent being the Poo-uli (Melamprosops phaeosoma) in 2004. The `I`iwi, a scarlet bird with black wings and tail, and a long curved, salmon-colored bill, is generally placed in the monotypic genus Vestiaria. It is a largely nectarivorous species that occurs commonly in closed canopy, high-stature native forests above 1500 m elevation (Fancy and Ralph 1998). `I`iwi breed and winter primarily in mesic and wet forests dominated by native 'ヨhi'a (Metrosideros polymorpha) and koa (Acacia koa) trees (Scott et al. 1986). They often travel widely in search of ‘ヨhi‘a flowers and are important ‘ヨhi‘a pollinators (Mitchel et al. 2005). The birds respond to seasonal flowering patterns, often moving to lower elevations where they are exposed to deadly disease (Pratt 2005). The `I`iwi uses its long bill to extract nectar from decurved corollas of Hawaiian lobelioids, which have become far less common on Hawaii over the past century (Smith et al. 1995). Female `I`iwi typically lay two eggs, and they alone are thought to incubate eggs and brood young (Mitchel et al. 2005). But males provision females with food off the nest. Breeding takes place predominantly from February to June, and is usually associated with peak flowering of 'ヨhi'a (Fancy and Ralph 1998). For native Hawaiians, the `I`iwi and other forest birds have a spiritual nexus. Feathered objects represented gods, ancestors, and divine lineage (Amante-Helweg and Conant 2009). Red feathers of clothing, such as cloaks, capes, and helmets, were predominantly from `I`iwi. Once a familiar sight on all main Hawaiian Islands, the `I`iwi remains an icon of Hawaii’s native forests. Today `I`iwi occur in higher elevation habitats largely free of avian disease, to which the species is highly susceptible. With climate change, these refugia may be lost entirely as pathogens and vectors advance upslope in response to higher ambient temperatures. This prognosis points to the needs for swift remedial action by responsible U.S. federal and State of Hawaii authorities to prevent the `I`iwi from joining the tragically long list of extinct or feared extinct Hawaiian birds (Banko and Banko 2009).
Relicts of deformed lithospheric mantle within serpentinites and weathered peridotites from the Godzilla Megamullion, Parece Vela Back‐arc Basin, Philippine Sea

Relicts of deformed lithospheric mantle have been identified within serpentinites and weathered peridotites recovered from nine dredge sites and one submersible dive site from across the Godzilla Megamullion, which was emplaced at the now‐extinct Parece Vela Rift in the Parece Vela Basin, a back‐arc basin in the Philippine Sea. The serpentinites consist dominantly of lizardite ± chrysotile and magnetite with minor relict primary minerals that include pyroxene, spinel, and rare olivine. The weathered peridotites consist of pyroxene, spinel, lizardite ± chrysotile, and magnetite as well as weathering products of olivine. These rocks were classified in hand specimen into three types with different structures: massive, foliated, and mylonitic. In thin‐section the serpentine minerals show no sign of deformation, whereas relict primary minerals show evidence of plastic deformation such as undulose extinction, kink bands, dynamic recrystallization, and weak to moderate crystallographic preferred orientations. Therefore, the serpentinites and weathered peridotites result from the static replacement and weathering of previously ductile‐deformed peridotite. Given their location close to or on the detachment surface that exposed them, the relicts of peridotite provide evidence of deformation in the lithospheric mantle that could be related to the formation and emplacement of the Godzilla Megamullion in the Parece Vela Rift.
Investigating the Effects of Block versus Statistical Glycopolycations Containing Primary and Tertiary Amines for Plasmid DNA Delivery

Polymer composition and morphology can affect the way polymers interact with biomolecules, cell membranes, and intracellular components. Herein, diblock, triblock, and statistical polymers that varied in charge center type (primary and/or tertiary amines) were synthesized to elucidate the role of polymer composition on plasmid DNA complexation, delivery, and cellular toxicity of the resultant polyplexes. The polymers were synthesized via RAFT polymerization and were composed of a carbohydrate moiety, 2-deoxy-2-methacrylamido glucopyranose (MAG), a primary amine group, N-(2-aminoethyl) methacrylamide (AEMA), and/or a tertiary amine moiety, N,N-(2-dimethylamino)ethyl methacrylamide (DMAEMA). The lengths of both the carbohydrate and cationic blocks were kept constant while the primary amine to tertiary amine ratio was varied within the polymers. The polymers were characterized via nuclear magnetic resonance (NMR) and size exclusion chromatography (SEC), and the polyplex formulations with pDNA were characterized in various media using dynamic light scattering (DLS). Polyplexes formed with the block copolymers were found to be more colloidally stable than statistical copolymers with similar composition, which rapidly aggregated to micrometer sized particles. Also, polymers composed of a higher primary amine content were more colloidally stable than polymers consisting of the tertiary amine charge centers. Plasmid DNA internalization, transgene expression, and toxicity were examined with each polymer. As the amount of tertiary amine in the triblock copolymers increased, both gene expression and toxicity were found to increase. Moreover, it was found that increasing the content of tertiary amines imparted higher membrane disruption/destabilization. While both block and statistical copolymers had high transfection efficiencies, some of the statistical systems exhibited both higher transfection and toxicity than the analogous block polymers, potentially due to the lack of a hydrophilic block to screen membrane interaction/disruption. Overall, the triblock terpolymers offer an attractive composition profile that exhibited interesting properties as pDNA delivery vehicles.
Trends in Postpartum Depressive Symptoms — 27 States, 2004, 2008, and 2012

Postpartum depression is common and associated with adverse infant and maternal outcomes (e.g., lower breastfeeding initiation and duration and poor maternal and infant bonding) (1-3). A developmental Healthy People 2020 objective is to decrease the proportion of women delivering a live birth who experience postpartum depressive symptoms (PDS). * To provide a baseline for this objective, CDC sought to describe self-reported PDS overall, by reporting state, and by selected sociodemographic factors, using 2004, 2008, and 2012 data from the Pregnancy Risk Assessment Monitoring System (PRAMS). A decline in the prevalence of PDS was observed from 2004 (14.8%) to 2012 (9.8%) among 13 states with data for all three periods (p<0.01). Statistically significant (p<0.05) declines in PDS prevalence were observed for eight states, and no significant changes were observed for five states. In 2012, the overall PDS prevalence was 11.5% for 27 states and ranged from 8.0% (Georgia) to 20.1% (Arkansas). By selected characteristics, PDS prevalence was highest among new mothers who 1) were aged ≤19 years or 20-24 years, 2) were of American Indian/Alaska Native or Asian/Pacific Islander race/ethnicity, 3) had ≤12 years of education, 4) were unmarried, 5) were postpartum smokers, 6) had three or more stressful life events in the year before birth, 7) gave birth to term, low-birthweight infants, and 8) had infants requiring neonatal intensive care unit admission at birth. Although the study did not investigate reasons for the decline, better recognition of risk factors for depression and improved screening and treatment before and during pregnancy, including increased use of antidepressants, might have contributed to the decline. However, more efforts are needed to reduce PDS prevalence in certain states and subpopulations of women. Ongoing surveillance and activities to promote appropriate screening, referral, and treatment are needed to reduce PDS among U.S. women.
Walking for Transportation or Leisure Among U.S. Women and Men — National Health Interview Survey, 2005–2015

Physical activity confers considerable health benefits, but only half of U.S. adults report participating in levels of aerobic physical activity consistent with guidelines (1,2). Step It Up! The Surgeon General's Call to Action to Promote Walking and Walkable Communities identified walking as an important public health strategy to increase physical activity levels (3). A previous report showed that the self-reported prevalence of walking for transportation or leisure increased by 6 percentage points from 2005 to 2010 (4), but it is unknown whether this increase has been sustained. CDC analyzed National Health Interview Survey (NHIS) data from 2005 (26,551 respondents), 2010 (23,313), and 2015 (28,877) to evaluate trends in the age-adjusted prevalence of self-reported walking among adults aged ≥18 years. The prevalence of walking increased steadily among women, from 57.3% in 2005, to 62.5% in 2010, and to 65.1% in 2015 (significant linear trend). Among men, a significant linear increase in reported walking was observed, from 54.3% in 2005, to 61.8% in 2010, and to 62.8% in 2015, although the increase stalled between 2010 and 2015 (significant linear and quadratic trends). Community design policies and practices that encourage pedestrian activity and programs tailored to the needs of specific population subgroups remain important strategies for promoting walking (3).
The stress changes that accompany strike-slip faulting

In a previous paper (Chinnery, 1961) an investigation of the deformation of the ground around a strike-slip fault was described. This work is now extended to a calculation of the change in stress distribution that is brought about by such a fault. Contour maps of the components of the stress change are included, both for the general rectangular fault, and for the limiting case of a long shallow fault. These maps have a number of interesting features, and show clearly the complexity of the stress change in the neighborhood of the edges of the fault plane. The assumptions involved in the calculation are discussed at some length.
Low RNA stability signifies strong expression regulatability of tumor suppressors

Abstract RNA expression of a gene is determined by not only transcriptional regulation, but also post-transcriptional regulation of RNA decay. The precise regulation of RNA stability in the cell plays an important role in normal development. Dysregulation of RNA stability can lead to diseases such as cancer. Here we found tumor suppressor RNAs tended to decay fast in normal cell types when compared with other RNAs. Consistent with a negative effect of m6A modification on RNA stability, we observed preferential deposition of m6A on tumor suppressor RNAs. Moreover, abundant m6A and fast decay of tumor suppressor RNAs both tended to be further enhanced in prostate cancer cells relative to normal prostate epithelial cells. Further, knockdown of m6A methyltransferase METTL3 and reader YTHDF2 in prostate cancer cells both posed stronger effect on tumor suppressor RNAs than on other RNAs. These results indicated a strong post transcriptional expression regulatability mediated by abundant m6A modification on tumor suppressor RNAs.
Solid lipid nanoparticles of lutein with improved dissolution behavior and oral absorption

Abstract The present study aimed to develop solid lipid nanoparticles of lutein (SLN/LT) with improved dissolution behavior and oral absorption. SLN/LT were prepared by a flash nanoprecipitation method using a multi-inlet vortex mixer, and their physicochemical, photochemical, and pharmacokinetic properties were evaluated. The mean particle size of SLN/LT re-dispersed in water was 237 nm, and small spherical particles with no significant aggregation were observed. LT significantly generated singlet oxygen upon exposure to pseudo-sunlight (250 W/m2, 1 h), suggesting its high photoreactivity. The remaining LT in LT solution, crystalline LT, and SLN/LT after irradiation with pseudo-sunlight (250 W/m2, 2 h) were 56.3, 86.7, and 101%, respectively. SLN/LT showed improved dissolution behavior of LT in simulated intestinal fluid, and the dissolved amounts of LT at 2 h were at least 50 times higher than that of crystalline LT. Orally administered SLN/LT (100 mg-LT/kg) exhibited enhanced oral absorption of LT, as evidenced by a relative bioavailability of 3.7 to crystalline LT in rats. SLN/LT may be a promising dosage form for orally available LT supplements, possibly leading to enhanced nutritional functions of LT.
Marine Pharmacology in 2009–2011: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action †

The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews of this series. The pharmacology of structurally-characterized compounds isolated from marine animals, algae, fungi and bacteria is discussed in a comprehensive manner. Antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral pharmacological activities were reported for 102 marine natural products. Additionally, 60 marine compounds were observed to affect the immune and nervous system as well as possess antidiabetic and anti-inflammatory effects. Finally, 68 marine metabolites were shown to interact with a variety of receptors and molecular targets, and thus will probably contribute to multiple pharmacological classes upon further mechanism of action studies. Marine pharmacology during 2009–2011 remained a global enterprise, with researchers from 35 countries, and the United States, contributing to the preclinical pharmacology of 262 marine compounds which are part of the preclinical pharmaceutical pipeline. Continued pharmacological research with marine natural products will contribute to enhance the marine pharmaceutical clinical pipeline, which in 2013 consisted of 17 marine natural products, analogs or derivatives targeting a limited number of disease categories.