Miracle-dz/UniFAR-FTUs huggingface dataset:
ISSN 2320-5407 International Journal of Advanced Research (2016), Volume 4, Issue 4, 1251-1258

Nesrine A Mohamed Background: The clinical experience gathered throughout the years endorses primary immunodeficiency diseases (PIDs) awareness and guides research into newborn screening and future therapeutic strategies.Combined T-cell receptor excision circle levels (TRECs) and kappa-deleting recombination excision circles (KRECs) assay paves the way to new potential applications in this field. Objectives: We aimed to establish a technique for quantification of TRECs and KRECs in Egyptian individuals in our laboratory and to set a lower threshold of normal for TRECs and KRECs in pediatric population for different age groups as a start for its implementation in newborn screening protocols for PIDs. Methods: 50 apparently healthy children (25 males and 25 females) with age ranging from 1 day to 16 years were analyzed.Combined quantification of TRECs and KRECs in the genomic DNA of peripheral blood mononuclear cells was performed using real-time quantitative PCR. Results: Individuals in the study were divided in to 5 different age groups Data regarding lower threshold of normal for TRECs and KRECs copies per ml of blood among the study group was obtained. A highly significant negative correlation between TRECs and KRECs, both calculated per 106 PBMCs and per ml of blood and age was observed. On the contrary, there was no statistically significant differences in the studied parameters between males and females when evaluated regardless of age (p value=0.697). Conclusion: It appeared that it is technically feasible to introduce the TRECs/KRECs quantitation by real time PCR into routine laboratory practice to be used in the near future both for new born screening for PIDs
Austin of Emergency and Critical Care Medicine Prediction, Identification, and Initial Treatment Guide for Scald Injuries

The prediction and treatment of hot-liquid scald injuries is complicated by the complex heat transfer within living tissue, incomplete information associated with scald incidents, and inherent limitations with accurate injury-depth estimation. To provide some guidance for the prediction, identification, and initial treatment, a single comprehensive resource is valuable. This review addresses these three issues. With regard to prediction, use is made of state-of-the-art hot-liquid scald information from the scientific literature. For both identification and treatment, the scientific literature and accepted standards of medical care are elucidated. The primary focus here is on hot-beverage spills because of their frequency; however, the results can be used for other hot-liquid scalding scenarios. Recommendations are made to avoid serious burn injuries and to rapidly treat injuries that occur.
Sammons, Pamela and Davis, Susila and Day, Christopher and Gu, Qing (2014) Using mixed methods to investigate school improvement and the role of leadership: an example of a longitudinal study

Purpose – The purpose of this paper is to discuss the use of mixed methods research in a major three year project and focuses on the contribution of quantitative and qualitative approaches to study school improvement. It discusses the procedures and multiple data sources used in studying improvement using the example of a recent study of the role of leadership in promoting improvement in primary and secondary schools’ academic results in England. Although the definition of improvement used was based on robust analyses of data on students’ academic outcomes, the mixed methods design enabled a broader perspective to be achieved. Design/methodology/approach – The study illustrates how the multilevel analysis of students’ national assessment and examination results based on national data sets for primary and secondary schools in England were used to investigate the concept of academic effectiveness based on value-added methodology. Using three successive years of national results a purposive sample of schools were identified that could be classified as both effective and improving over the period 2003-2005. In addition, surveys and interviews were used to gather evidence of the role of stakeholder perceptions in investigating school improvement strategies and processes. Findings – National student attainment data sets were used for the identification of improving and effective schools and revealed the importance of considering their different starting points in their classification of three distinctive improvement groups. The combination of quantitative survey data from headteachers and key staff with qualitative case study data enabled a range of analysis strategies and the development of statistical models and deeper understanding of the role of leadership. Research limitations/implications – The limitations of a focus on only academic outcomes and “value-added” measures of student progress are discussed. The challenges and opportunities faced in analysis and integration of the different sources of evidence are briefly explored. Practical implications – The study contributes to the knowledge base on the identification of school improvement and use of performance data. The findings on strategies and processes that support improvement are of relevance to policy makers and practitioners, especially school leaders. Originality/value – The mixed methods design adopted in the study enabled the research to combine rigorous quantitative and in-depth qualitative data in new ways to extend and make new claims to knowledge about the role of school leadership in promoting school improvement based on the study of effective and improved schools’ experiences.
Analyzing Immunoglobulin Repertoires this article Please share how this access benefits you. Your story matters

Somatic assembly of T cell receptor and B cell receptor (BCR) genes produces a vast diversity of lymphocyte antigen recognition capacity. The advent of efficient high-throughput sequencing of lymphocyte antigen receptor genes has recently generated unprecedented opportunities for exploration of adaptive immune responses. With these opportunities have come significant challenges in understanding the analysis techniques that most accurately reflect underlying biological phenomena. In this regard, sample preparation and sequence analysis techniques, which have largely been borrowed and adapted from other fields, continue to evolve. Here, we review current methods and challenges of library preparation, sequencing and statistical analysis of lymphocyte receptor repertoire studies. We discuss the general steps in the process of immune repertoire generation including sample preparation, platforms available for sequencing, processing of sequencing data, measurable features of the immune repertoire, and the statistical tools that can be used for analysis and interpretation of the data. Because BCR analysis harbors additional complexities, such as immunoglobulin (Ig) (i.e., antibody) gene somatic hypermutation and class switch recombination, the emphasis of this review is on Ig/BCR sequence analysis.
Estimation of genetic variation by the components of gene diversity

the Genetic variation is apportioned to components due to variation within and between populations or samples (years etc.) usin? the antilogarithir! of Shannon's entr:ipy as index of gene diversity. Differences in alleie frequencies between samples are tested by a likelihood-ratio test. G-test. This test requires pooling of samples instead of proportions for calculation of average divershi. *s. Without testing it is possible to partition divrsity by perling proportions. which gives equal weight to each sample G-test diso requires that. natural logarithms are used for calculation of Shannon's entropy. lormulae of gene diversity are given for a two-dimensional measurement, say arinai and between-population -. ariation. Diversity is particularly suitable for the measurement of association in contingency tables. but these assoi.ia- tion";ar eesied as a by-product. Several loci can be analyzed simultaneously, because likelihood ratios, degrees of freedoms, and gene diversities are additive: they can 'Or summed o\er many loci.
Fault Detection in Fortran 2015

The presence of billions of hardware components and several levels of software stack in High Performance Computing machines will likely represent an increment in number of hardware and software failures, which will be user-visible. Although several techniques to address this problem have been developed, the support provided by the programming model, for the user to mitigate or workaround this issue, is still insufficient. The Fortran 2015 standard defines failed images , a new feature that allows the programmer to detect and manage image failures in a parallel program. In this paper we present the failed images implementation provided by the GNU Fortran Compiler and OpenCoarrays based on the User-Level Failure Mitigation proposal presented in the MPI Forum. We also provide tangible example of the differences between fault detection and fault tolerance.
Basics of High-Speed Electrical Machines Basics of High-Speed Electrical Machines

The high-speed electrical machines are widely used in different industries, such as mach- ine tools, aerospace engineering, autonomous power engineering, etc. This chapter is devoted to the basics of high-speed electrical machines with high-coercitivity permanent magnets. It is considered in the application areas of high-speed electrical machines and their classifications. In addition, design problems of high-speed electrical machines are shown. To estimate the efficiency, loss calculations are performed. The obtained results can be used in the design of high-speed electrical machines with high-coercitivity perma- nent magnets and in their future development.
THERAPEUTICS, PHYTOCHEMISTRY AND PHARMACOLOGY OF AN IMPORTANT UNANI DRUG KALONJI ( NIGELLA SATIVA LINN): A REVIEW

The seed of Nigella sativa , Linn is known as Kalonji . The plant Nigella sativa is a short-lived, aromatic, annual herb. It is an amazing herb with a rich historical and religious background. The height of the plant is approximately 20-60 cm. The seeds are angular, of generally small size. They are black or dark gray with a rough grooved surface and an oily white interior. The seeds are the source of active ingredients of this plant. The seeds have an immense medicinal value and are known to have numerous medicinal properties. They are also used for flavouring and seasoning bread, pickles, and bakery products. It is among widely used seeds and has been employed either as a medicinal grain or as a food ingredient in several countries. The plant has shown diverse biological and pharmacological activities. It has been used in Unani Medicine ( Tibb-e-Unani ) and other Traditional Systems of Medicine from time immemorial. Keeping in view the medicinal importance of the drug in Unani Medicine, an attempt has been made to review the available literature on traditional uses and pharmacological properties of the plant.
Should industry fund continuing medical education and scientific communications?

This new journal closes an important gap in the ESC Journals Family—we welcome Acute Cardiovascular Care writes Professor Thomas Lüscher Editor-in-Chief, European Heart Journal. Acute Cardiac Care is an area of cardiology that is increasingly recognized as a subspeciality in its own right. Most patients admitted to intensive care units and coronary care units suffer from acute coronary syndromes, cardiogenic shock, cardiac arrest, cardiac arrhythmias, and acute heart failure—major life-threatening conditions requiring the coordination of multidisciplinary teams to deliver state-of-the-art treatment to improve the outcome in these patients. The EHJ-ACVC journal will offer a unique integrated approach combining the expertise of the different subspecialities of cardiology, emergency, and intensive care medicine, in the management of patients with acute cardiovascular syndromes. Prof. Christiaan Vrints, from Antwerp University Hospital in Belgium and Editor-in-Chief of the European Heart Journal: Acute Cardiovascular Care, said: ‘We cover a much needed platform focusing on patient care, ranging from the pre-hospital phase to the time the patients leave the Intensive or Coronary Care Unit. Our new journal is not disease specific or limited to the scope of a particular methodology. We encompass the entire spectrum of diagnostic and treatment capabilities and the multidisciplinary nature of modern health care. The European Heart Journal: Acute Cardiovascular Care aims at translating new evidence-based concepts into daily clinical care and will therefore also have a strong educational focus’. The editorial board of the journal gathers peer reviewers from all over Europe. Through their expertise, the European Heart Journal: Acute Cardiovascular Care will publish the highest quality material, both clinical and scientific, on all aspects of acute cardiac care. The first issue—to be published in spring 2012—will be a landmark publication and one which includes research from some of the most prominent research groups in the field. The journal is to be widely distributed online and in print formats. To contribute to the new European Heart Journal: Acute Cardiovascular Care and submit a paper, the manuscript submission site may be accessed at http://www.editorialmanager. com/acc/.
In vivo RNAi analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults

The Drosophila immune system discriminates between different classes of infectious microbes and responds with pathogen specific defense reactions via the selective activation of the Toll and the Immune Deficiency (Imd) signalling pathways. The Toll pathway mediates most defenses against Gram-positive bacteria and fungi while the Imd pathway is required to resist Gram-negative bacterial infection. Microbial recognition is achieved through Peptidoglycan Recognition Proteins (PGRPs): Gram-positive bacteria activate the Toll pathway through a circulating PGRP (PGRP-SA), and Gram-negative bacteria activate the Imd pathway via PGRP-LC, a putative transmembrane receptor, and PGRP-LE. Gram-negative binding proteins (GNBPs) were originally identified in Bombyx mori for their capacity to bind various microbial compounds. Three GNBPs and two related proteins are encoded in the Drosophila genome but their function is not known. Using inducible expression of GNBP1 double stranded RNA, we now demonstrate that GNBP1 is required for Toll activation in response to Gram-positive bacterial infection: GNBP1 double stranded RNA expression renders flies susceptible to Gram-positive bacterial infection and reduces the induction of the antifungal peptide encoding gene Drosomycin after infection by Gram-positive bacteria but not after fungal infection. This phenotype induced by GNBP1 inactivation is identical to a loss-of-function mutation in PGRP-SA , and our genetic studies suggest that GNBP1 acts upstream of the Toll ligand Spätzle. Altogether, our results demonstrate that the detection of Gram-positive bacteria in Drosophila requires two putative Pattern Recognition Receptors, PGRP-SA and GNBP1.
The impact of new technology on lifestyle and health : a psychological perspective

The invention of machines, computers and other technological artefacts has improved our mental abilities too. Technology can make us smart (Norman, 1993) by increasing our abilities to remember better, by storing information in different formats, and support our reasoning activities. Thanks to computers we can perform complex calculations quickly, simulate processes of different kind, create art and music, and so on. Technology has also helped us to pick up information that earlier was impossible to pick up. Microscopes and telescopes, only to mention a few technological devices, have made it possible for us to look into worlds that we otherwise would not have any access to. New intelligent hearing aids have helped people with hearing deficits to pick up auditory information better and improved the possibilities to communicate with other people.
Functions and Mechanisms of Receptor Tyrosine Kinase Torso Signaling: Lessons From Drosophila Embryonic Terminal Development

The Torso receptor tyrosine kinase (RTK) is required for cell fate speciﬁcation in the terminal regions (head and tail) of the early Drosophila embryo. Torso contains a split tyrosine kinase domain and belongs to the type III subgroup of the RTK superfamily that also includes the platelet-derived growth factor receptors, stem cell or steel factor receptor c-Kit proto-oncoprotein, colony-stimulating factor-1 receptor, and vascular endothelial growth factor receptor. The Torso pathway has been a model system for studying RTK signal transduction. Genetic and biochemical studies of Torso signaling have provided valuable insights into the biological functions and mechanisms of RTK signaling during early Drosophila embryogenesis.
Fabrication of a Silicon Nanowire Solar Cell on a Silicon-on-Insulator Substrate

This study proposes metal-assisted chemical etching (MAE) as a facile method to fabricate silicon nanowire (SiNW) array structures, with high optical confinement for thin crystalline silicon solar cells. Conventional SiNW arrays are generally fabricated on Si wafer substrates. However, tests on conventional SiNW-based solar cells cannot determine whether the photo-current is derived from SiNWs or from the Si wafer. Herein, SiNW arrays were fabricated on a silicon-on-insulator substrate with a 10-μm-thick silicon layer for measuring the photocurrent of the SiNW only. The 9 μm-long p-type SiNW arrays were applied to a solar cell structure fabricated using an n-type H-doped amorphous Si layer, thereby confirming the photovoltaic effect. However, the device exhibited a conversion efficiency of 0.0017% because of a low short-circuit current (Jsc) and a low open-circuit voltage (Voc). The low Jsc resulted from a high series resistance and high absorption loss from the amorphous Si layer, whereas the low Voc resulted from the high surface recombination velocity of the SiNW array structure. Therefore, reducing the surface recombination of SiNW-based solar cells can improve their conversion efficiency.
Modified Feature DescriptorBased Approach to Recognize Surgically Altered Human Faces

— Plastic Surgery is being cited as one of the major challenges for face recognition issues. Plastic surgery method significantly alters the facial regions by modifying the appearances, facial features, textures, both locally and globally. These features greatly affect routine of algorithm on the database of plastic surgery, which contains both local and global face images. The study clearly depicts how the commonly used algorithms suffer in identifying and reflecting the modifications done by plastic surgery procedures.For finding the closeness between the pre-surgical face and post-surgical face closeness between the pre and post-surgical faces are found out by extracting the nose, eyes and lips feature.In this paper, an attempt has been made to develop a novel technique to recognize surgically altered images using Modified Feature Descriptor (MFD) technique and Adaptive Feature Matching (AFM). MFD consist of two steps, firstly an encoding scheme is devised that compresseshigh-dimensional dense features into a compact representationby maximizing the intrauser correlation. Secondly AFM is developed for effective classification. The proposed system is compared with two state of the art techniques to recognize surgically altered human faces are firstly Local Binary Pattern and Local Derivative Patternbased approach and secondly Local Binary Pattern and Principle Component Analysisbased approach. The proposed system is validated using IIIT-Delhi Plastic Surgery Face Database.
NANOSPONGES: NOVEL STRATEGY FOR TARGETED DRUG DELIVERY SYSTEM: A REVIEW

: Owing to miniaturisation, dose-depletion, continuous and restrictive liberation of active substances, well established material constancy, the field concerned with advanced nanostructured systems has seen rapid growth in recent years. Nanosponge’s invention has become an important step in overcoming the problems of poorly water-soluble drugs which show many traditional formulating complications. Nanosponge is a compact virus sized sponges (250nm-1um) that credibly stuffed by a broad range of medications and travel across the body until it binds with a certain pointed spot and sticks to the exterior and releases the drug in a restrained manner. This review focuses on methods of preparation, nanosponge applications, factors effecting the drug delivery area, characterization of nanosponges. Nanosponges are an essential conveyor that supply active substances as well as therapeutic medicine delivery process in the medicament industry in post-validate clinical trials. These helps to deliver the drugs at the targeted sites without effecting the healthy cells as well as shows less/or no side-effects. Nanosponges review helps to understand the advantages of this new medication method over conventional medication system. By enhancing the solubility of poorly water-soluble drugs these hels to deliver the drugs, orally as well as topically without first pass metabolism. This is the upcoming system of medication.
Use of semantic and business analytics to monitor integrations between enterprise applications in IT

This paper presents a model to track interface activities in order to increase the Quality of Service (QoS) delivered by integrations between enterprise applications in the manufacturing industry. Following the guidelines of business analytics, a descriptive model is built over an ontology, which assembles meaning from meta-data and business entities that are conveyed in each interface. On top of that, a semantic analysis breaks down the context of issues, evaluating the severity and the number of occurrences of the problem in a timespan, it also notifies experts when needed to galvanize actions and expedite solutions. The main contribution of this model relies on building a framework that enables knowledgeable workers to engineer analysis of issues occurring in integrations that are connected to a central application such as a Manufacturing Execution System (MES). The principal claim is that by automating smart notifications and decisions, the QoS can improve.
International Journal of Advanced Research in Computer Science and Software Engineering Architectural Design issues and Challenges-WSN

- Wireless sensor network (WSN) is an infrastructure less, low cost, dynamic topology, application oriented, Multi hoping network design with small, low power, sensing wireless distributed nods. WSN designing become more complex due to characteristics of deploying nodes, security, authentication and its operation scenario. This paper presents an analytical view on WSN architecture design issues, its objectives and implementation challenges.