Miracle-dz/UniFAR-FTUs huggingface dataset:
Pharmacological Therapies for the Management of Inflammatory Bone Resorption in Periodontal Disease: A Review of Preclinical Studies

Periodontitis, a highly prevalent multicausal chronic inflammatory and destructive disease, develops as a result of complex host-parasite interactions. Dysbiotic bacterial biofilm in contact with the gingival tissues initiates a cascade of inflammatory events, mediated and modulated by the host's immune response, which is characterized by increased expression of several inflammatory mediators such as cytokines and chemokines in the connective tissue. If periodontal disease (PD) is left untreated, it results in the destruction of the supporting tissues around the teeth, including periodontal ligament, cementum, and alveolar bone, which lead to a wide range of disabilities and poor quality of life, thus imposing significant burdens. This process depends on the differentiation and activity of osteoclasts, the cells responsible for reabsorbing the bone tissue. Therefore, the inhibition of differentiation or activity of these cells is a promising strategy for controlling bone resorption. Several pharmacological drugs that target osteoclasts and inflammatory cells with immunomodulatory and anti-inflammatory effects, such as bisphosphonates, anti-RANK-L antibody, strontium ranelate, cathepsin inhibitors, curcumin, flavonoids, specialized proresolving mediators, and probiotics, were already described to manage inflammatory bone resorption during experimental PD progression in preclinical studies. Meantime, a growing number of studies have described the beneficial effects of herbal products in inhibiting bone resorption in experimental PD. Therefore, this review summarizes the role of several pharmacological drugs used for PD prevention and treatment and highlights the targeted action of all those drugs with antiresorptive properties. In addition, our review provides a timely and critical appraisal for the scientific rationale use of the antiresorptive and immunomodulatory medications in preclinical studies, which will help to understand the basis for its clinical application.
ARS: web page recommendation system for anonymous users based on web usage mining

Web now becomes the backbone of the information. Today the major concerns are not the availability of information but rather obtaining the right information. Mining the web aims at discovering the hidden and useful knowledge from web hyperlinks, contents or usage logs. This paper focuses on improving the prediction of the next visited web pages and recommends them to the current anonymous user based on web usage mining technique where many data mining techniques applied to web server logs. We proposed ARS to recommend to the anonymous web user by assigning him to the best navigation profiles obtained by previous navigations of similar interested users based on his early stage navigation. To represent the anonymous user's navigation history, we used a window sliding method with size n over his current navigation session. Using CTI dataset the experimental results show higher prediction accuracy for the next visited pages for anonymous users compared to previous recommendation system.
IMITAR? DIFERENCIAR? CONTINUAR IGUAL? ESTRATÉGIAS DA ACADEMIA EDU´S PARA LIDAR COM A NOVA CONCORRENTE / IMITATE? DIFFERENTIATE? CONTINUE THE SAME WAY? STRATEGIES OF EDU’S GYM TO DEAL WITH THE NEW COMPETITOR

Eduardo e o proprietario de uma academia ja estabelecida ha anos na cidade e encontra-se em uma situacao desconfortavel diante da abertura de uma nova concorrente, praticamente em frente ao seu empreendimento. A nova academia promete oferecer diferenciais que o empreendimento de Eduardo nao oferece – equipamentos mais modernos, horarios mais atrativos e climatizacao. A mensalidade anunciada pela nova concorrente e praticamente equivalente a praticada na academia de Eduardo. Diante do cenario que esta sendo criado, ele tera que encontrar estrategias para lidar com a nova concorrente e manter o seu empreendimento viavel. Palavras-chave: Estrategia. Estrategias genericas. Visao Baseada em Recursos (VBR). Abstract Eduard is the owner of a gym that has been established in the town for years, but now finds himself in na uncomfortable situation, due to the opening of a new competitor practically opposite his establishment. The new gym promises to offer advantages that the Eduard’s enterprise does not offer - more modern equipment, more attractive opening hours, and air conditioning. The monthly fee announced by the new competitor is the same as that practiced by Eduard´s Gym. Faced with this scenario, he will need to find strategies to deal with the new competitor and ensure his business remains viable. Keywords: Strategy. Generic Strategies. Resource Based View (RBV).
Neutrophil infiltration combined with necrosis in the primary tumor is a useful prognostic indicator for three-year disease-free survival time in patients with colorectal cancer

Histopathological evaluation plays a key role in the diagnosis of colorectal cancer (CRC). Tumor-related local inflammation is regarded as a novel prognostic parameter. Neutrophils constitute one of the main types of inflammatory cells. The aim of the present study was to evaluate the prognostic value of intratumoral tumor-associated neutrophils (intraTANs), stromal TANs (stromaTANs) and necrosis, as well as their combined parametric value in formalin-fixed paraffin-embedded tissue sections from patients with CRC. For this purpose, a retrospective study of 160 patients with CRC who underwent surgery was conducted. The association of intraTANs, stromaTANs, necrosis and their combined parametric value with the clinicopathological features of patients with CRC was examined. The Kaplan-Meier method and the log-rank test were used to compare survival curves. To identify independent prognostic factors, uni- and multivariate Cox proportional hazards regression models were used. StromaTANs were associated with lymph node metastasis (P=0.049) and tumor deposits (P=0.041). In addition, necrosis was found to be associated with venous (P=0.003), lymphatic (P=0.007) and perineural (P=0.015) invasion, as well as with lymph node metastasis (P=0.033), the number of invaded lymph nodes (P=0.012), and lymph node pouch invasion (P=0.043). Furthermore, necrosis was found to be associated with the white blood cell count (P=0.030), neutrophil count (P=0.011), the combined neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (NLR-PLR) (P=0.038), and the combined platelet and NLR (PLT-NLR status) (P=0.030), as well as with the serum carcinoembryonic antigen (CEA) levels following surgery (P=0.011) and the monocyte-to-lymphocyte ratio (P=0.023). The combined parametric value was found to be associated with pT stage (P=0.049), venous (P=0.034) and lymphatic (P=0.026) invasion, and with serum CEA levels prior to surgery (P=0.029). The analysis of the 3-year disease-free survival (DFS) time revealed that tumor growth [hazard ratio (HR), 2.070; 95% CI, 1.837-3.808; P=0.003] and the combined parametric value (intraTANs, stromaTANs and necrosis, HR, 1.577; 95% CI, 1.372-3.032; P=0.028) were independent factors for patients with CRC. Taken together, the findings of the present study demonstrated that the combined value of neutrophils and necrosis examined in the cancerous tissue may be used as a prognostic factor for the 3-year DFS time in patients with CRC.
PAPR Reduction in MIMO-OFDM via Power Efficient Transmit Waveform Shaping

In this paper we revisit the long standing problem of peak-to-average power ratio minimization in MIMO-OFDM systems, with a new angle of approach on a well-known scheme. Utilizing the principles of tone reservation, we place dummy symbols, i.e., complex coefficients, on unused space-frequency resources with the aim to jointly minimize the transmit signal PAPR and the self-power consumption of the dummy symbols. This joint minimization is solved using three different proposed algorithms exhibiting varying degrees of computational complexity and PAPR reduction performance. Our proposed framework utilizes the strict PAPR expression, i.e., we take into account the average transmit power of the antenna, to simultaneously reduce the PAPR on all antennas while keeping the self-power consumption of the scheme minimal. Our simulation results show that this optimization objective provides better worst-case PAPR reduction and dummy symbol power consumption performance compared to the peak power minimization objective widely utilized in the tone reservation literature. Finally, we propose a novel take on a well-known block-diagonalization algorithm by exploiting knowledge on dummy symbol allocations, resulting in high-gain data streams in downlink transmission.
Robust supervisory control policy for automated manufacturing systems with a single unreliable resource

Over the past two decades, the development of supervisory controllers that guarantee deadlock-free operation for automated manufacturing systems (AMSs) has been an active area of research. Most work to date assumes that the system resources are reliable. This paper focuses on the robust supervisory control problem of AMSs with a single unreliable resource. Our objective is to develop a robust supervisory control policy under which the system can continue producing in the face of the unreliable resource’s failure or recovery. To do so, we integrate an optimal deadlock avoidance policy based on a Petri net with a modified Banker’s Algorithm and present a novel robust supervisory control policy. It is proven to be of polynomial complexity and more permissive than two existing policies. Also, experimental results on a set of AMSs generated randomly indicate its superiority over all other existing policies.
Molecular Detection and Differentiation of Arthropod, Fungal, Protozoan, Bacterial and Viral Pathogens of Honeybees

The honeybee Apis mellifera is highly appreciated worldwide because of its products, but also as it is a pollinator of crops and wild plants. The beehive is vulnerable to infections due to arthropods, fungi, protozoa, bacteria and/or viruses that manage to by-pass the individual and social immune mechanisms of bees. Due to the close proximity of bees in the beehive and their foraging habits, infections easily spread within and between beehives. Moreover, international trade of bees has caused the global spread of infections, several of which result in significant losses for apiculture. Only in a few cases can infections be diagnosed with the naked eye, by direct observation of the pathogen in the case of some arthropods, or by pathogen-associated distinctive traits. Development of molecular methods based on the amplification and analysis of one or more genes or genomic segments has brought significant progress to the study of bee pathogens, allowing for: (i) the precise and sensitive identification of the infectious agent; (ii) the analysis of co-infections; (iii) the description of novel species; (iv) associations between geno- and pheno-types and (v) population structure studies. Sequencing of bee pathogen genomes has allowed for the identification of new molecular targets and the development of specific genotypification strategies.
Preparation of Antibacterial Gelatin/Genipin Nanofibrous Membrane for Tympanic Membrane Repair

Tympanic membrane perforation (TMP), a common disease, often needs a scaffold as the patch to support surgery. Due to the environment of auditory meatus, the patch can be infected by bacteria that results in failure; therefore, the ideal scaffold may combine biomimetic and antibacterial features. In this work, gelatin was used as the electrospinning framework, genipin as the crosslinking agent, and levofloxacin as an antibacterial in order to prepare the scaffold for TMP. Different contents of levofloxacin have been added to gelatin/genipin. It was found that, with the addition of levofloxacin, the gelatin/genipin membranes exhibit improved hydrophilia and enhanced tensile strength. The antibacterial and cell-cultured experiments showed that the prepared antibacterial membranes had excellent antibacterial properties and good biocompatibility, respectively. In summary, levofloxacin is a good group for the gelatin/genipin scaffold because it improves the physical properties and antibacterial action. Compared with different amounts of levofloxacin, a gelatin/genipin membrane with 1% levofloxacin is more suitable for a TM.
Weathering-Resistant Replicas Fabricated by a Three-Dimensional Printing Robotic Platform Induce Shoaling Behavior in Zebrafish

In recent decades, zebrafish have become an increasingly popular laboratory organism in several fields of research due to their ease of reproduction and rapid maturation. In particular, shoaling behavior has attracted the attention of many researchers. This article presents a fully printed robotic model used to sense and stimulate shoaling behavior in zebrafish (Danio rerio). Specifically, we exposed laboratory-fabricated replicated materials to critical acid/base/salt environments and evaluated the mechanical, optical, and surface properties after a three-month immersion period. Focusing on weatherability, these test samples maintained high tensile strength (~45 MPa) and relatively similar transmission (>85%T in the visible region), as determined by UV–vis/FTIR spectroscopy. Three-dimensional (3D) printing technology allowed printing of models with different sizes and appearances. We describe the sense of zebrafish responses to replicas of different sizes and reveal that replicas approximating the true zebrafish size (3 cm) are more attractive than larger replicas (5 cm). This observation suggests that larger replicas appear as predators to the zebrafish and cause fleeing behavior. In this study, we determined the weatherability of a high-transparency resin and used it to fabricate a fully printed driving device to induce shoaling by zebrafish. Finally, we demonstrate a weathering-resistant (for three months) 3D-printed decoy model with potential utility for future studies of outdoor shoaling behavior, and the result has the potential to replace the traditional metal frame devices used in outdoor experiments.
CNN-LSTM Based Approach for Dos Attacks Detection in Wireless Sensor Networks

—A denial-of-service (DoS) attack is a coordinated attack by many endpoints, such as computers or networks. These attacks are often performed by a botnet, a network of malware- infected computers controlled by an attacker. The endpoints are instructed to send traffic to a particular target, overwhelming it and preventing legitimate users from accessing its services. In this project, we used a CNN-LSTM network to detect and classify DoS intrusion attacks. Attacks detection is considered a classification problem; the main aim is to clarify the attack as Flooding, Blackhole, Normal, TDMA, or Grayhole. This research study uses a computer- generated wireless sensor network-detection system dataset. The wireless sensor network environment was simulated using network simulator NS-2 based on the LEACH routing protocol to gather data from the network and preprocessed to produce 23 features classifying the state of the respective sensor and simulate five forms of Denial of Service (DoS) attacks. The developed CNN-LSTM model is further evaluated on 25 epochs with accuracy, Precision score, and Recall score of 0.944, 0.959, and 0.922, respectively, all on a scale of 0-1.
Role of suppressing GLT‐1 and xCT in ceftriaxone‐induced attenuation of relapse‐like alcohol drinking in alcohol‐preferring rats

Alcohol dependence results in long‐lasting neuroadaptive changes in meso‐corticolimbic system, especially in the nucleus accumbens (NAc), which drives relapse‐like ethanol drinking upon abstinence or withdrawal. Within NAc, altered glutamate homeostasis is one of the neuroadaptive changes caused by alcohol dependence. Accumbal glutamate homeostasis is tightly maintained through glutamate transporter 1 (GLT‐1) and cystine‐glutamate antiporter (xCT). But the role of GLT‐1 and xCT in relapse‐like ethanol drinking is poorly understood. Here, we used alcohol‐preferring (P) rats in relapse‐like ethanol drinking paradigm to (a) determine the effect of relapse‐like ethanol drinking on gene and protein expression of GLT‐1 and xCT in NAc, measured by quantitative polymerase chain reaction (qPCR) and Western blot, respectively; (b) examine if glutamate uptake is affected by relapse‐like ethanol drinking in NAc, measured by radioactive glutamate uptake assay; (c) elucidate if upregulation of either/both GLT‐1 or/and xCT through ceftriaxone is/are required to attenuate relapse‐like ethanol drinking. The GLT‐1 or xCT protein expression was suppressed during ceftriaxone treatments through microinjection of GLT‐1/xCT anti‐sense vivo‐morpholinos. We found that relapse‐like ethanol drinking did not affect the gene and protein expression of GLT‐1 and xCT in NAc. The glutamate uptake was also unaltered. Ceftriaxone (200 mg/kg body weight, i.p.) treatments during the last 5 days of abstinence attenuated relapse‐like ethanol drinking. The suppression of GLT‐1 or xCT expression prevented the ceftriaxone‐induced attenuation of relapse‐like ethanol drinking. These findings confirm that upregulation of both GLT‐1 and xCT within NAc is crucial for ceftriaxone‐mediated attenuation of relapse‐like ethanol drinking.
A Mechatronics Approach for Design of Multiview Image Acquisition Setup for Scene Reconstruction with Single Camera

Conventional design approach is being actively replaced by concurrent design approach in the context of interdisciplinary systems. The proposed research work intends to develop a single moving camera based stereo vision system for scene reconstruction with the intrinsic advantage of multi-directional fields of view. The conventional stereo vision setup uses two stationary passive cameras to capture images of a scene from different vantage points. The proposed system imparts varying mechanical degrees of freedom motion for both the object and the camera which aids in acquiring sequence of images which covers all the visible regions of the object of interest. This gives better detail of the scene under consideration as compared to the conventional two images based stereopsis. A mechatronics design approach has been presented which carefully integrates various elements of the system such as the mechanisms, actuators, sensors and the electronic controller. The paper clearly pin points the cues for the design of the mechanical system which are obtained from the requirements of the computer vision system. The relative pose between the camera and the scene is governed by three independent degrees of freedom namely rotation angle for the object, tilt and working distance for the camera. The selection of the aforementioned parameters is decided by the specifications such as field of view, size of the object and sensor and spatial resolution. The proposed design predicts the system to enjoy benefits of reduced cost and improved flexibility in general.
Relationships Between Technology, Social Media and Sexual Behavior among University Students

Technology and social media nowadays has become a common phenomenon in this 21 st century among youth. Everybody have their own technology which is smartphone and social media has been developed more from time to time until arouse the bad consequences among youth. This study aims to identify the relationships between technology usage and social media exposure towards sexual behavior among youth where the university students as the main focus. This study also look up about the differences between gender male and female towards sexual behavior. This study applies quantitative methods that involved questionnaire distributions to respondents. A total of 250 students from The National University of Malaysia (UKM) had been recruited by using convenience sampling technique. The results of this study found there is a significant, positive relationship between social media exposure and sexual behavior and for technology usage there is no significant relationships towards sexual behavior. For gender differences there is no significant difference between male and female towards sexual behavior. The results showed sexual behavior has been developed because of social media exposure instead of technology usage. For gender differences showed that male and female have same sexual behavior.
THE NEURAL NETWORK IMPLEMENTATION IN PATTERN RECOGNITION OF SEMICONDUCTOR ETCHING PROCESS

ABSTRACT In the semiconductor manufacturing, product endpoint curve in the etching process can be used to determine if any abnormality exists in the process. Real-time monitoring of changes in the product endpoint curve in situ can allow early detection of abnormalities and prevent losses from these abnormalities. This research has focused on discovering a feasible way to replace manual monitoring and the curve determination currently used on production lines. In this study, we take advantage of a unique neural network curve classification feature-the self-learning feature. The Back-Propagation Neural Network (BPNN) was used as the backbone of this study. Etching endpoint curve digital data collected from wafer fab was used as analysis database. This study selected 200 samples from each of the 3 randomly chosen process recipes to train the learning process. This study also used the remaining 100 samples as a comparison to our trained results. The classification results in an accuracy of over 96%. Therefore, this system can reduce the uncertainty in the process curve classification and provide in-time and effective suggestions for shutting down machines on the production line.
Design & seleção de materiais: elaboração e execução de um sistema de informações para projeto do produto: madeiras

1 Luiz Antonio Vasques Hellmeister, Professor Assistente Doutor do Departamento de Artes e Representação Gráfica, DARG-FAAC-UNESP-Bauru, SP, Brasil, hellmeister@faac.unesp. br 2 João Fernando Marar, Professor Adjunto do Departamento de Computação, DCo-FC-UNESP-Bauru, SP, Brasil, fermarar@fc.unesp. br Abstract ⎯ Wood is a renewable material and has unique characteristics that stem from its orthotropic properties. The objective of this study was to develop and implement an informational Selection of Materials and Manufacturing Processes appropriate to the activity of Product Design Woods. Composed of a Digital Information System, distributed, and an ordered collection of samples. The design of a product, carries with it the choice of material, and the choice of a manufacturing process. Information on materials and manufacturing processes are available with different content, media and interfaces. However, such information is not systematized so that they can be recovered, as the need for the designer, especially on wood. This set of methods is called the Selection of Materials and Manufacturing Processes. It is hoped through this study that the methodologies for SMPF are employed by product designers, architects and engineers in Brazil.