Miracle-dz/UniFAR-FTUs huggingface dataset:
Genome-wide association study and transcriptome analysis reveal key genes affecting root 1 growth dynamics in rapeseed 2

21 Root growth is a dynamic process mediated by interactive genetic factors and environmental cues. 22 Seven root-related traits and two shoot-related traits in 280 Brassica napus accessions at five 23 continuous vegetative stages were measured to establish the genetic basis of root growth in rapeseed. 24 The persistent and stage-specific genetic mechanisms were revealed by root dynamic analysis. 25 Sixteen persistent and 32 stage-specific quantitative trait loci (QTL) clusters were identified through 26 genome-wide association study (GWAS). Root samples with contrasting (slow and fast) growth rates 27 throughout investigated stages and those with obviously stage-specific changes in growth rates were 28 subjected to transcriptome analysis. The former identified 367 differentially expressed genes (DEGs) 29 with persistently differential expressions throughout root development that were significantly 30 enriched in GO terms of energy metabolism and response to biotic or abiotic stress, whereas the later 31 identified 485 stage-specific DEGs with different expressions at corresponding stage that were 32 enriched in GO terms of nitrogen metabolism. By integrating GWAS, weighted gene co-expression 33 network analysis (WGCNA), and differential expression analysis, four and eight candidate genes 34 less than 100 kb away from peak SNPs of QTL clusters were identified as key persistent and 35 stage-specific genetic factors, respectively . The homologs of 3 genes ( BnaA03g52990D , 36 BnaA06g37280D, and BnaA09g07580D ) out of 12 candidate genes have been reported to regulate 37 root development in previous studies. Our results provide new insights into the temporal genetic 38 mechanisms of root growth by identifying key candidate QTL/genes in rapeseed. seven (RIL) two of QTL (persistent of identify the genetic factors the dynamic examined five continuous stages during root development in natural accessions of Sixteen persistent and 32 stage-specific QTL confirmed the existence of the two types of QTL controlling root development. we performed a transcriptome analysis of samples of four root growth types with extremely contrasting growth rates during the investigated A of
Unintended Pregnancy in Rural Communities

Background: Unintended pregnancy accounted for 45% of all pregnancies in the US in 2011. This is more prevalent than many other developed countries and has been studied in women with varying ages, races, income levels, and education; however little research has been dedicated to unintended pregnancy in rural populations. Objective: To identify whether there is an association between unintended pregnancy and geographical location in New York State. Intent of pregnancy based on maternal age and education was also analyzed. Methods: A retrospective cohort study using the Statewide Perinatal Database System (SPDS) to extrapolate maternal demographics including education level, age, and pregnancy intention for pregnancies between 2004 to 2015. RUCA codes delineated Rural, Suburban, or Urban residence. We analyzed the data using relative risk as a measure of association between geographical location and pregnancy intent. A confidence interval of 95% with a p <0.05 was considered significant. Results: SPDS Data from 210,999 pregnancies between 2004 to 2015 were analyzed. Rural women had similar percentages of unintended pregnancy (34.5% vs 35.8%). Rural women were not at increased risk of unintended pregnancy based on geographical location. The risk for unintended pregnancy decreased as maternal age increased. There was an increased risk for unintended pregnancy with lower maternal education, illustrating an inverse relationship similar to maternal age. Conclusion: Rural-Urban variation in health care is well documented, although rural women have similar percentages of unintended pregnancy. More attention is necessary to ensure sufficient distribution of family planning resources. studies have also shown that women with the least amount of education attained have the highest rates of unintended pregnancy In 2011, women without a high school degree had the highest unintended pregnancy among those of any education level (73 per 1,000), with rates declining further with each level of education attained). Poor and low-income women have an unintended pregnancy rate approximately five times the rate for women in the highest income bracket there are few studies investigating unintended pregnancy rates of rural-urban
Circular Cavity Based Photonic Bandpass Filter Designed on Two Dimensional Hexagonal Lattice Used in Satellite Communication

— A two dimensional hexagonal photonic crystal based circular bandpass filter (2D-PCBPF) basically designed in L-band, which find it application in various satellite communication. Here we are using circular cavity based PC BPFs which is proposed and investigate. The output efficiency and bandwidth of circular bandpass filter studied by varying the rode radius of the cavity. In this paper, we are using photonic crystal structure, consist of gallium (III) arsenide with RI value 3.927, which found its application in various satellite communication. The circular cavity based band pass filter gives better performance than others because of its circular resonating modes in the cavity. The simulation result is obtained using 2D finite difference time domain method (FDTD method). The photonic bandgap is calculated by plane wave expansion (PWE) method. The overall size of the 2D- PCBPF is 11.2 𝞵 m X 9.5 𝞵 m.
SOLUBILITY ENHANCEMENT OF NIFEDIPINE BY USING LIQUISOLID COMPACT TECHNIQUE

This study evaluated the feasibility of liquisolid compact as an innovative drug delivery system to improve the solubility of the poorly soluble drug Nifedipine. There are several techniques to enhance the dissolution of poorly soluble drugs. Among them, the technique of liquisolid compact is most promising technique towards novel aim. Several formulations of liquisolid compact having different drug concentration (20-40% w/w) and with varying ratios of carrier and coating material (i.e. different R value, from15-20) were prepared. In this study Polyethylene glycol 400 (PEG400) as a solvent, Avicel PH 102 as a carrier and Aerosil-200 as a coating material were used. The interaction between excipients was examined by Attenuated Total Reflectance infrared spectroscopy. DSC suggested loss of nifedipine crystallinity upon liquisolid formulation, it indicates that drug is held within the power substrate in a solubilised, almost molecularly dispersed state, which lead to enhanced drug solubility. The results showed that liquisolid compacts demonstrate significantly higher drug release rates than those of marketed ones (% drug release of marketed product-19.5% and LS 3 -28.5% after 10 minutes). This was due to an increase in wetting properties and surface of drug available for dissolution. Increased wetting properties and dissolution rates lead to enhance solubility. The liquisolid technique appears to be a promising approach for improving the solubility of poorly soluble drugs.
Novel Approach to the Development of Effective H5N1 Inﬂuenza A Virus Vaccines: Use of M2 Cytoplasmic Tail Mutants (cid:1)

Outbreaks of highly pathogenic H5N1 inﬂuenza viruses in avian species began in Asia and have since spread to other continents. Concern regarding the pandemic potential of these viruses in humans is clearly warranted, and there is an urgent need to develop effective vaccines against them. Previously, we and others demonstrated that deletions of the M2 cytoplasmic tail caused a growth defect in A/WSN/33 (H1N1) inﬂuenza A virus in vitro (K. Iwatsuki-Horimoto, T. Horimoto, T. Noda, M. Kiso, J. Maeda, S. Watanabe, Y. Muramoto, K. Fujii, and Y. Kawaoka, J. Virol. 80:5233–5240, 2006; M. F. McCown and A. Pekosz, J. Virol. 79:3595–3605, 2005; M. F. McCown and A. Pekosz, J. Virol. 80:8178–8189, 2006). We therefore tested the feasibility of using M2 tail mutants as live attenuated vaccines against H5N1 virus. First we generated a series of highly pathogenic H5N1 (A/Vietnam/1203/04 [VN1203]) M2 cytoplasmic tail deletion mutants and examined their growth properties in vitro and in vivo. We found that one mutant, which contains an 11-amino-acid deletion from the C terminus (M2del11 virus), grew as well as the wild-type virus but replicated in mice less efﬁciently. We then generated a recombinant VN1203M2del11 virus whose hemagglutinin (HA) gene was modiﬁed by replacing sequences at the cleavage site with those of an avirulent type of HA (M2del11-HAavir virus). This M2del11-HAavir virus protected mice against challenge with lethal doses of homologous (VN1203; clade 1) and antigenically distinct heterologous (A/Indonesia/7/2005; clade 2) H5N1 viruses. Our results suggest that M2 cytoplasmic tail mutants have potential as live attenuated vaccines against H5N1 inﬂuenza viruses.
Faraday Pilot-Wave Hydrodynamics: Modelling and Computation

A millimetric droplet bouncing on the surface of a vibrating ﬂuid bath can self-propel by virtue of a resonant interaction with its own wave ﬁeld (Couder et al. 2005a; Proti`ere et al. 2006). This system represents the ﬁrst known example of a pilot-wave system of the form envisaged by Louis de Broglie in his double-solution pilot-wave theory (de Broglie 1930, 1956, 1987). We here develop a numerical model of pilot-wave hydrodynamics by coupling recent models of the droplet’s bouncing dynamics (Mol´aˇcek & Bush 2013a,b) with a more realistic model of weakly viscous wave generation and evolution. (Lamb 1932; Dias et al. 2008). The resulting model is the ﬁrst to capture a number of features reported in experiment, including the rapid transient wave generated during impact, the Doppler eﬀect, and walker-walker interactions.
‘Liberalisation, and Institutions: Evidence from Italian and Greek Banking’. Work, Employment & Society . Vol. 28, No. 1, pp.40-57. Liberalisation, Flexibility and Industrial Relations Institutions: Evidence from Italian and Greek Banking

: The article seeks to explain how institutions change within varieties of capitalism, focussing on an important institution for the world of work: wage bargaining. Although there was a widespread expectation that the markets’ liberalisation and the firms’ needs for flexibility would bring convergence to the Liberal Market model of decentralised industrial relations, recent literature emphasised that diversity persists and there was a range of different responses. The article contributes to this debate by applying a coalitional perspective to highlight the factors that influence divergent trajectories of change in wage bargaining. The case studies, of Italian and Greek banking, suggest that the existence of ‘employer associability’ may moderate decentralising tendencies and facilitate the reform of industrial relations institutions, while ‘labour-state coalitions’ are critical for the institutions’ survival. Finally, the article discusses the findings in relation to wider debates in the comparative political economy of work.
Role of International Higher Education in Developing Employability: Limitations and Opportunities

: Employability of graduates is one of the current policy concerns emerging in higher education developments and the implementation of Bologna process. It calls for a continued proactive role of universities and other higher education institutions toward developing lasting employability. The research was conducted to evaluate the performance of the MSc Programme Land Management and Land Tenure at Technische Universitaet Muenchen, Germany in developing better employability of their students. 39 alumni took part in questionnaire survey and focus group discussion. The survey results showed high levels of graduates’ satisfaction concerning studies in MSc Programme Land Management and Land Tenure as a whole. During interview the alumni also confirmed that different aspects of the academic programme (e.g. curriculum, international experience, alumni networks) had the highest influence on their career development. However, some factors were identified which hinder the employability opportunity of alumni. The research proved that networking, pragmatic curriculum and international experience has positive effects on the alumni’s career development. However, the research results showed that employability attributes are necessary for getting jobs but not always sufficient. Employment opportunities are affected to some extent by non-employability factors also. The research analysis indicated fairly obvious criterion of relevant work experience which is necessary for getting a job. Alumni confirmed that some other factors like high competition in job market, lack of personal contact, lack of desirable jobs may create problems in getting suitable job. Tie with family responsibility and safety issue in remote area also squeeze the job opportunity. But these factors are stronger for women than men.
Isolation of lipolytic bacteria from Colombian Andean soils A target for bioprospecting

oil (1%). Two isolates identified as Pseudomonas psychrophila and Stenotrophomonas rhizophila produced the largest hydrolysis halos, with an optimal activity at pH 8 and 50°C. Only the S. rhizophila extracellular fraction hydrolyzed short and long chain pNP-esters, including pNP-palmitate. The broader substrate specificity of this isolate is probably due to the simultaneous presence of lipase and esterase activity in the crude extract. This is the first report of lipolytic activity in S. rhizophila , and the first preliminary characterization of the novel lipolytic activity in S. rhizophila and P. psychrophila. Further work is needed to purify and completely characterize the esterases and lipases produced by both species.
IBM SAN Distance Matrix Project Trace coverage and modeling across IBM test labs world-wide

—Storage Area Networks (SAN) solutions are highly complex, often with enterprise class quality requirements. To perform end-to-end customer-like SAN testing, multiple complex interoperability test labs are necessary. One key factor in field quality is test coverage; in distributed test environments this requires a centralized view and coverage model across the different areas of test. We define centralized coverage models and apply our novel trace coverage technology to automatically populate these models. Early results indicate that we are able to create a centralized view of SAN coverage across the multitude of IBM test labs world-wide. Moreover, we are able to compare test lab coverage models with customer environments. Based on these views and comparisons, we expect to obtain an increased coverage, resulting in increased discovery rate of high-impact defects .
OpenCL-Generated Optimizing Compiler for FPGA Using ROSE Compiler Infrastructure

— Many researchers are investigating deep learning because it can recognize pedestrians for automatic driving and/or criminals to prevent crimes on the street. A promising device for such tasks in deep learning is a Field Programmable Gate Array (FPGA). However, the conventional manual FPGA programming and optimizations are complicated and take a long time. Thus, FPGA development time needs to be decreased. In this paper, we propose an OpenCL-generated optimizing compiler based on the ROSE Compiler Infrastructure. OpenCL is a C-extended programming language for heterogeneous computing, such as an FPGA and a Central Processing Unit (CPU). We add simple pragmas to the C program, and our compiler generates the optimized OpenCL program for FPGA. The preliminary evaluation using the deep learning framework Caffe shows that our compiler decreases to about 1/16 of the conventional development time.
HILIGAYNON – CEBUANO SENTENCE TRANSLATOR USING RECURRENT NEURAL NETWORKS

In the Philippines, two of the most spoken dialects are Cebuano and Hiligaynon. Moreover, Cebuano and Hiligaynon are closely related in the sense that both languages share words but have different meaning according to context. The study aimed to create a translation model for Hiligaynon to Cebuano by applying recurrent artificial neural networks with long short-term memory. Two neural networks were developed, one for encoding source sentences and one for decoding target sentences in a manner following sequence-to-sequence learning. The highest accuracy achieved was when the model was trained at 150 epochs and 4000 sentences, yielding a BLEU score of 0.265579454. It can be concluded that a neural machine translation model can be created given sufficient training data.
A Plug-in Node Architecture for Dynamic Traffic Control

—Accurate traffic classification is fundamental to many network activities such as an analysis of the application usage, anomaly detection, and accounting. However, the architecture of most network devices is strictly fixed. We need a dynamic architecture to deal with increasing traffic. We therefore propose a plug-in node for dynamic traffic control. A plug-in node is designed to load and unload traffic processing plug-in modules on the fly. Plug-ins can be implemented with various functions including packet classification, anomaly detection, and application monitoring.
AWE AND PERSPECTIVE TAKING

Understanding another’s perspective is an essential component of a healthy social interaction. However, the motivation to empathize with others can often be low. My thesis investigated whether the emotion of awe may motivate perspective taking. I found that dispositional awe was positively correlated with multiple trait measures of perspective taking. However across a variety of analyses inducing awe did not consistently promote greater accuracy and reduce reaction time in a visual perspective taking task compared to neutral and amusement control conditions. I found evidence that awe improved overall cognitive flexibility, but it is not clear that this flexibility is specific to taking another’s visual perspective. These results suggest that awe may be related to dispositional perspective taking or perspective taking at a higher social cognitive level, but it does not affect other-focused visual attention or perspective taking.
Performance Analysis of Multiuser DS-CDMA System

- This paper examines the Bit Error Rate (BER) performance of Multi-user Direct Sequence Code Division Multiple Access (DS-CDMA) using spreading codes in fading channels. Code Division Multiple Access (CDMA) system operating over frequency selective, slowly fading channels is considered and its performance is studied analytically and by computer simulations. We consider the downlink of a cellular radio system where for each user a BPSK modulation is used. The spreading codes are arranged in a way that reduces the effect of the multipath fading channel and restores some of the orthogonality losses between users. The obtained results show considerable performance improvement compared to conventional OFDM and to CDMA that uses single spreading codes. Moreover, the spreading codes chosen by the method are in a consistent sequence. Using this code selection method, the system capacity of MU-CDMA can be effectively increased without increasing too much system complexity. Simulation results show that the presented method can work well for fading channels.
Boundary element methods for particles and microswimmers in a linear viscoelastic (cid:13)uid

The consideration of viscoelasticity within (cid:13)uid dynamical boundary element methods has traditionally required meshing over the whole (cid:13)ow domain. In turn a major advantage of the boundary element method is lost, namely the need to consider only surface boundary integrals. Here, using a generalised reciprocal relation and viscoelastic force singularities, a boundary element method is developed for linear viscoelastic (cid:13)ows. We proceed to explore (cid:12)nite deformation microswimming in a linear Maxwell (cid:13)uid. We (cid:12)rstly deduce a (cid:12)nite amplitude generalisation of a previously reported result that the (cid:13)ow (cid:12)eld is unchanged between a Newtonian and linear Maxwell (cid:13)uid for prescribed small amplitude deformations. Hence Purcell’s theorem holds for a linear Maxwell (cid:13)uid. We proceed to consider deformation swimming in a linear Maxwell (cid:13)uid given an external forcing. Boundary scattering trajectories for an exemplar squirmer approaching a surface are observed to exhibit a weak dependence on the Deborah number, while the trajectories of a sperm and monotrichous bacterium near a surface are predicted to be essentially unaﬀected at moderate Deborah number. In turn, the latter supports the common simpli(cid:12)cation of using Newtonian Stokes (cid:13)ows for studying (cid:13)agellate swimming in linear Maxwell media. In addition, the motion of a magnetic helix under the in(cid:13)uence of an external magnetic (cid:12)eld is considered, and highlights that linear viscoelasticity can signi(cid:12)cantly impact the propagation of the helix, in turn demonstrating that even linear rheology is important to consider for forced swimmers. Finally, the presented framework requires minimalistic adjustments to Newtonian boundary element codes, enabling rapid implementation and is more generally applicable, for instance to studies of particle interactions in active linear rheology on the microscale. swimming dynamics between in Newtonian-Stokes (cid:13)ow and in linear viscoelastic (cid:13)ow has been investigated only for in(cid:12)nitesimally small deformation (Lauga 2014), and that this study provides a theoretical extension for particles and swimmers with an arbitrary volume-conserving deformation. In addition, such an extension (cid:12)rst enables one to construct a boundary element scheme that is discussed in details in the following sections. We subsequently examine the dynamics of swimmers near boundaries, for the (cid:12)nite deformation swimming of a tangential squirmer, a monotrichous (singly (cid:13)agellated) bacterium and a mammalian sperm. In particular we examine the impact of linear Maxwell viscoelasticity and whether it in(cid:13)uences the mechanics of microswimmer boundary scattering and boundary accumulation, with the latter referring to the tendency of (cid:13)agellated microswimmers to swim adjacent to surfaces.
Regenerative responses following genotoxicity vary along the anterior/posterior axis in Schmidtea mediterranea

Summary statement: This report shows different stem cell responses against a genotoxic agent in regenerating planarian in anterior versus posterior fragments and suggests a link with differential β-catenin activity along the body-axis. Abstract Pluripotent stem cells hold great potential for regenerative medicine and as such understanding the fundamental mechanisms that effect their behaviour in adult tissue is important. Increased replication and division such is the case during regeneration, concomitantly increases the risk of adverse outcomes through the acquisition of mutations. Seeking for driving mechanisms of such outcomes, we challenged a pluripotent stem cell system during the tightly controlled process of regeneration in the planarian Schmidtea mediterranea . Exposure to the genotoxic compound methyl methanesulfonate revealed that despite a similar DNA-damaging effect along the anterior/posterior axis of intact animals, stem cell responses differed between anterior and posterior fragments after amputation. Stem cell proliferation and differentiation processes proceeded successfully in the amputated heads, leading to regeneration of missing tissues. Stem cells in the amputated tails however, showed decreased proliferation and differentiation capacity. As a result, tails were not able to regenerate. Interference with the body-axis-associated component β-catenin-1 increased regenerative success in tail fragments, suggesting that differences in the Wnt signalling gradient along the body axis modulate different stem cell responses to MMS.