Miracle-dz/UniFAR-FTUs huggingface dataset:
Multidrug-resistant and carbapenemase-producing critical gram-negative bacteria isolated from the intensive care unit environment in Amhara region, Ethiopia

Background Intensive care units are units where healthcare-associated infections (HAIs) are common and antimicrobial resistance rates are increasing. Microbial contamination in hospital environment plays an important role in the development of HAIs. Intervention-based improvements in infection prevention and control at national and facility level are critical for the containment of antimicrobial resistance and prevention of HAIs. Objectives This study aimed to determine the distribution of multidrug-resistant and carbapenemase-producing critical gram negative bacteria (Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Acinetobacter species) and their antibiotic resistance in intensive care unit environmental surfaces at the University of Gondar and Felege Hiwot Comprehensive Specialized Hospitals. Methods This was multicenter hospital-based cross sectional study. Environmental samples were swabbed from all intensive care units using a normal saline moistened-sterile cotton tip stick. Bacteria culturing and antibiotic susceptibility testing were performed following standard microbiological techniques. Selected meropenem-resistant isolates were phenotypically assessed for carbapenemase production using modified and simplified carbapenem inactivation methods. Results From a total of 384 environmental samples analyzed, 126 (32.8%) showed growth and 162 isolates were identified. K. pneumoniae (79/162, 48.8%) was the commonest isolate followed by Acinetobacter species (51/162, 31.5%), E. coli (19/162, 11.7%) and P. aeruginosa (13/162, 8.0%). Multidrug-resistant and carbapenemase-producing isolates were detected on most hospital environment surface types, especially from the baby bed sets and incubators. The most common multidrug-resistant and principal carbapenemase producer was K. pneumoniae, with rates of 71(89.9%) and 24(85.7%), respectively. Conclusion This study revealed the distribution of multidrug-resistant and carbapenemase-producing critical gram negative bacteria in the environment of intensive care unit. Higher detection rate of multidrug-resistant and carbapenemase-producing K. pneumoniae on most environmental surfaces calls for urgent control action and further attention.
Isolation, identification of entomopathogenic nematodes with insights into their distribution in the Syrian coast regions and virulence against Tuta absoluta

Abstract The occurrence and distribution of entomopathogenic nematodes (EPNs) in the Syrian coast regions remain relatively uncharted. To address this gap in our knowledge, an extensive survey of these ecosystems was essential. This study aims to isolate and identify EPNs from diverse ecosystems within the coastal regions. The distribution of EPNs in cultivated and natural environments was analyzed according to habitat, altitude, and sampling season factors. Between 2017 and 2020, EPNs were recovered from 27 out of 821 soil samples (3.28%) and collected from 24 out of 375 sampling sites (6.4%). Based on morphological, morphometric, and molecular (ITS) characteristics, four EPN species were identified: Heterorhabditis indica (51.85%), representing the first report of its occurrence in the coastal regions, H. bacteriophora (33.33%), H. pakistanense (7.4%), which is also reported for the first time in Syria, and Steinernema affine (7.4%). There were statistical differences in the abundance and recovery frequency of EPNs in each type of habitat. Additionally, there were statistical differences in the altitude and sampling season recovery frequency. Co-inertia analysis revealed correlation between the distribution and occurrence of EPNs in vegetation habitats, altitude, and sampling seasons, as well as some soil characteristics. H. indica and H. bacteriophora were associated with citrus orchards, low-altitude ranges, moderate organic matter, and acidic soil. More specifically, H. indica isolates were correlated with olive orchards, vegetable fields, autumn season, and clay, sandy, and sandy loam soils. Meanwhile, H. bacteriophora isolates were correlated with tobacco fields, grasslands, alkaline pH, spring season, silty loam, and clay loam soils. H. pakistanense was linked to pear orchards, vineyards, moderate pH, and low organic matter. S. affine occurred in walnut orchards, silty soil, higher altitudes, and winter season. The virulence levels of three native EPN isolates (S. affine, H. indica and H. bacteriophora) were evaluated against 3rd and 4th instar larvae (outside and inside mines) and pupae of T. absoluta, a destructive pest in Syria. All three native EPN species exhibited ability to infect and kill the insect, with observed significant differences in their virulence. This study provides an understanding of EPN occurrence, distribution, and their potential for application in sustainable pest control strategies in Syria.
Association between alexithymia, emotional intelligence, smoking addiction, and alcohol use disorder among a sample of Lebanese adults

Background Alexithymia can be associated with worse addictive traits, while emotional intelligence is associated with better addictive outcomes. In Lebanon, the prevalence of cigarette and waterpipe smoking is on the rise, although people are aware of the associated harms. Also, around 11% of Lebanese adults have experienced alcohol use disorder (AUD). This study aimed to assess the association between alexithymia, emotional intelligence, smoking (cigarette and waterpipe), and AUD among a sample of Lebanese adults. Methods A web-based cross-sectional study carried out between February and April 2020, during the lockdown period, enrolled 408 community-dwelling adults. The survey link was shared on social media to reach participants from all Lebanese districts/governorates. Results Taking antidepressants (Beta = 4.37) was significantly associated with more cigarette dependence, while female gender (Beta = -1.52) and having a high vs. low monthly income (Beta = 1.02) were significantly associated with less cigarette dependence. None of the variables, including alexithymia, were significantly associated with waterpipe dependence. Female gender (Beta = -0.15) and higher emotional intelligence (Beta = -0.003) were significantly associated with less AUD, whereas higher alexithymia (Beta = 0.003) was significantly associated with more AUD. Conclusion This study could demonstrate a significant association between alexithymia and cigarette smoking and alexithymia and alcohol consumption. Future research is warranted to investigate the mediating effect of emotional intelligence and how these results may be used to meet the needs of alexithymic individuals with addictions.
National and subnational burden of leukemia and its risk factors, 1990–2019: Results from the Global Burden of Disease study 2019

Background Hematologic malignancies have a great essential role in cancer global burden. Leukemia which two major subtypes based on the onset, is one of the common subtypes of this malignancy. Method For the GBD 2019 study, cancer registry data and vital registration system were used to estimate leukemia mortality. The Meta-Regression-Bayesian Regularized Trimmed (MR-BRT), Cause of Death Ensemble model (CODEm) and Spatiotemporal Gaussian Process Regression (ST-GPR) were used to model our data and estimate each quantity of interest. Mortality to incidence ratios (MIR) were used to generate incidence and survival from mortality rate. Prevalence and survival were used to generate years lived with disability (YLDs). Age-specific mortality and life expectancy at the same age were used to estimate years of life lost (YLLs). The sum of YLLs and YLDs generates DALYs. Results The total national incidence of leukemia increased from 6092 (UI 95%: 3803–8507) in 1990 to 6767 (4646–7890) new cases in 2019. However, leukemia age-standardized incidence ratio(ASIR) decreased from 11.6 (8–14.8) to 8.9 (6.2–10.3) new cases per 100,000 in this exact period. At the national level, deaths from leukemia increased 1.5-fold between 1990 and 2019, from 3287 (2284–4201) to 4424 (3137–5030), whereas the age-standardized death rate(ASDR) decreased from 8.3 (6.1–9.8) in 1990 to 6 (4.3–6.8) per 100,000 in 2019. In the study period, total leukemia DALYs decreased 12.2% and reached 162850 (110681–188806), in 2019. The age-standardized DALYs decreased 36.7% from 324.3 (224.8–413.4) in 1990 to 205.3 (140.3–237.8) in 2019. ASDR, DALYs, YLLs, and YLDs rate to high BMI was increasing while smoking and occupational exposure to benzene and formaldehyde were decreasing in the study period. Conclusion This study provided a better understanding of leukemia burden and to reduce controversies of leukemia across Iran. The leukemia status alteration of the country, is trackable.
Hf Isotope Evidence for a Miocene Change in the Kerguelen Mantle Plume Composition

We report high-precision multiple collector inductively coupled plasma INTRODUCTION mass spectrometry (MC-ICP-MS) analyses of Hf isotopic comSpatial and temporal isotope variations in basalts can positions for 39 Kerguelen Archipelago volcanic rocks that add a provide important constraints on the origin of the mantle new perspective to the temporal evolution of the Kerguelen mantle source of hotspots, plume dynamics and the interaction plume. Samples cover the entire range of chemical and Sr, Nd and of plumes with the oceanic lithosphere. The relationships Pb isotopic variations reported for the archipelago, and vary in age between ocean island basalts (OIB) and mantle geofrom 29 to 0·1 Ma. Their Hf isotopic compositions show the chemistry have been investigated in recent publications largest variation for an individual oceanic island and Hf correlates on both ridge-axis hotspots (Iceland; Hanan & Schilling, negatively with alkalinity. The Hf–Nd isotopic compositions of the 1997; Chauvel & Hemond, 2000; Kempton et al., 2000), pre-Miocene flood basalt group (>25 Ma) are distinct from those and within-plate hotspots (Hawaii; e.g. Lassiter et al., of the 25 Ma group 1986), and are therefore critical for delimiting the range of flood basalts require interaction between a shallow reservoir of of enriched isotopic variations for OIB, and (2) during asthenospheric mantle or oceanic lithosphere and the Kerguelen plume formation of the Kerguelen Archipelago the environment core, best represented by the Mt. Crozier basalts on the archipelago. of the hotspot changed from ridge-centred at >40 Ma This scenario is consistent with the relative proximity of the Kerguelen to the present intra-plate position. The archipelago has Archipelago to the Southeast Indian Ridge (>300–400 km) when been centred on or near the hotspot because the Antarctic the >25 Ma flood basalts erupted. The younger alkaline volcanic plate has remained essentially stationary with respect to rocks were generated by low-degree melting in the plume envelope, the hotspot reference frame since the Eocene (Duncan an area of enriched mantle material, different from the plume core, & Richards, 1991). The recent extensive and systematic and presumably formed by different combinations of old recycled sampling of volcanic stratigraphic sections from the Keroceanic crust and plateaux. The enriched geochemical character of guelen Archipelago provides a new framework within the Kerguelen plume core supports the hypothesis that the EM Iwhich to study the evolution of the Kerguelen plume. type plume source includes recycled oceanic plateaux. The Kerguelen Archipelago formed on the northernmost part of the Kerguelen Plateau on the Antarctic plate, far from continental margins. In contrast to the
Did intense volcanism trigger the first Late Ordovician icehouse

Oxygen isotopes measured on Late Ordovician conodonts from Minnesota and Kentucky (United States) were studied to reconstruct the paleotemperature history during late Sandbian to Katian (Mohawkian–Cincinnatian) time. This time interval was characterized by intense volcanism, as shown by the prominent Deicke, Millbrig, and other K-bentonite beds. A prominent carbon isotope excursion (Guttenberg δ 13 C excursion, GICE) postdates the Millbrig volcanic eruptions, and has been interpreted to reflect a drawdown of atmospheric carbon dioxide and climatic cooling. The oxygen isotope record in conodont apatite contradicts this earlier interpretation. An increase in δ 18 O of 1.5‰ (Vienna standard mean ocean water) just above the Deicke K-bentonite suggests an abrupt and short-lived cooling that possibly initiated a first short-term glacial episode well before the major Hirnantian glaciation. The decrease in δ 18 O immediately after the mega-eruptions indicates warming before the GICE, and no cooling is shown in the GICE interval. The coincidence of the Deicke mega-eruption with a cooling event suggests that this major volcanic event had a profound effect on Late Ordovician (late Mohawkian) climate.
Opening a portal to pleasure based sexual and reproductive health around the globe; a qualitative analysis and best practice development study

Abstract Pleasure is often left out of sexual and reproductive health and rights (SRHR) interventions. The expanding evidence base suggests that the inclusion of pleasure can improve SRHR outcomes and increase safer sex practices. However, there is a lack of research into how to include pleasure in applied SRHR work, particularly outside of key groups. This study aims to present the experiences of a cohort of pleasure implementers and develop a series of implementation best practices. Data were gathered from a structured survey filled out by pleasure implementers (n = 8) twice between September 2021 and October 2022 at 6-month intervals. Focus group discussions (FGDs) were carried out remotely with pleasure implementers, those that funded their pleasure work (n = 2) or provided technical support (n = 2) in January 2023. Pleasure implementers, based in Central, East and Southern Africa and India, reported tangible outcomes of their pleasure-based work in various contexts and across diverse groups. Themes that emerged from analysis of the FGDs and survey responses included pleasure as a portal to positive outcomes, barriers to a pleasure approach, and mechanisms by which pleasure allows for open and non-judgmental discussion about sex and pleasure. A series of best practices emerged from pleasure implementer experiences. This study concludes that a pleasure-based approach can be introduced to a wide range of groups and communities, even those assumed too conservative to accept a pleasure approach. The best practices developed offer a range of practically driven recommendations, that others can lean on when integrating a pleasure approach into their work.
Pathobiology of nodal peripheral T-cell lymphomas: current understanding and future directions

Predominantly nodal is the most common clinical presentation of peripheral T- (and NK-) cell lymphomas (PTCL), which comprise three main groups of diseases: (i) systemic anaplastic large cell lymphomas (ALCL), whether positive or negative for anaplastic lymphoma kinase (ALK); (ii) follicular helper T-cell lymphomas (TFHL); and (iii) PTCL, not otherwise specified (NOS). Recent advances in the genomic and molecular characterization of PTCL, with enhanced understanding of pathobiology, have translated into significant updates in the latest 2022 classifications of lymphomas. ALK-negative ALCL is now recognized to be genetically heterogeneous, with identification of DUSP22 rearrangements in approximately 20-30% of cases, correlated with distinctive pathological and biological features. The notion of cell-of-origin as an important determinant of the classification of nodal PTCL is best exemplified by TFHL, considered as one disease or a group of related entities, sharing oncogenic pathways with frequent recurrent epigenetic mutations as well as a relationship to clonal hematopoiesis. Data are emerging to support that a similar cell-of-origin concept might be relevant to characterize meaningful subgroups within PTCL, NOS, based on cytotoxic and/or Th1 versus Th2 signatures. The small group of primary nodal Epstein-Barr virus-positive lymphomas of T- or NK-cell derivation, formerly considered PTCL, NOS, is now classified separately, due to distinctive features, and notably an aggressive course. This review summarizes current knowledge of the pathology and biology of nodal-based PTCL entities, with an emphasis on recent findings and underlying oncogenic mechanisms.
A Visual Content Analysis of Stigma Communication in the Depictions of Individuals with Obesity in U.S. and U.K. News.

Weight stigma is a pervasive form of discrimination worldwide. News media, and news images in particular, can reinforce weight stigma by portraying persons with obesity in a negative, stereotypical manner. Informed by the model of stigma communication, this study conducted a content analysis of images accompanying obesity-related news articles from the U.S. and U.K. to determine and compare the prevalence of stigmatizing images. Images (N = 445) in obesity-focused news articles obtained from the top four most viewed online news in the U.S. (n = 244) and U.K. (n = 201) during August 2018-August 2019 were systematically coded. These 445 images featured 228 individuals. Of these 228 individuals, 35% were identified as higher weight and 44% as lower weight. Overall, 70% of persons of higher weight in these news images were depicted in a stigmatizing manner. Further, 46% of individuals with higher weight were depicted with their head partially or fully removed from the image, compared to 25% of individuals with lower weight. Additionally, U.K. news were 2.5 times more likely to contain stigmatizing images than U.S. news. These findings highlight the prevalence of weight stigma in news images and suggest that broader systemic efforts are needed by the news media industry to eliminate the use of negative imagery that marginalizes persons of higher weight.
Impact of Geodynamics on Diagenetic By-products - An Input to Petro-acoustic Modeling of Pre-salt Carbonates

Diagenesis of the atypical presalt carbonate deposits is controlled by hydrothermal CO2-rich fluids circulation. In low CO2 pressure conditions, most of the reservoirs are plugged by Mg-clays (no reservoir). When the CO2 pressure is increasing, the Mg-clays can be leached and replaced by dolomitic rhombs, creating a good reservoir network. Precipitation of siliceous cement is also a by-product of the presence of the CO2, mainly in cooler areas. All these different fluids/rock alterations steps can be fossilized at different stages observed on thin sections. In-house coupled stratigraphical and diagenetical forward modeling of continental carbonates has been launched. First results are very promising and let possible to model carbonate springs in aerial conditions, which was not possible with the current forward modelling tools. This integrated approach will be used to experiment different geological scenarios (sedimentological and diagenetical) as imput to forward seismic modelling for derisking exploration and appraisal of the pre-salt play.
Role of Actinomyces spp. and related organisms in the development of medication-related osteonecrosis of the jaw (MRONJ): Clinical evidence based on a case series

Abstract Medication-related osteonecrosis of the jaw (MRONJ) is an increasingly common consequence of antiresorptive treatment, which often leads to the development of necrotic exposed bone surfaces with inflammatory processes affecting the jawbone. Although the development of MRONJ is often associated with the inflammatory response or infections caused by the colonizing members of the oral microbiota, the exact pathogenesis of MRONJ is still not fully understood. In the present paper, we aimed to provide additional, microbiological culture-supported evidence, supporting the “infection hypothesis” that Actinomyces spp. and related organisms may play an important pathogenic role in the development of MRONJ and the resulting bone necrosis. In our case series, all patients presented with similar underlying conditions and anamnestic data, and have received antiresorptive medications (bisphosphonates or a RANK ligand (RANKL) inhibitor) to prevent the occurrence or progression of bone metastases, secondary to prostate cancer. Nevertheless, a few years into antiresorptive drug therapy, varying stages of MRONJ was identified in the mentioned patients. In all three cases, quantitative microbiological culture of the necrotic bone samples yielded a complex microbiota, dominated by Actinomyces and Schaalia spp. with high colony counts. Additionally, our followed-up case series document the treatment of these patients with a combination of surgical intervention and long-term antibiotic therapy, where favourable clinical responses were seen is all cases. If the “infection hypothesis” is valid, it may have significant consequences in the preventative and therapeutic strategies associated with this disease.
Numerical experiments of the storm track sensitivity to oceanic frontal strength within the Kuroshio/Oyashio Extensions

The sensitivity of the North Pacific storm track to midlatitude oceanic frontal strength within the Kuroshio/Oyashio Extensions is investigated by applying artificially changed meridional sea surface temperature (SST) gradients in the Weather Research Forecasting model version 3.4. The result of sensitivity experiments further confirms the close relationship between the storm track activity and meridional SST gradient; i.e., the storm track activity can be intensified as a response to increases in the oceanic frontal strength. In order to better understand the mechanism for the storm track intensification due to increased SST gradient, velocity‐temperature correlation and local energetics are analyzed. The result indicates that the enhancement of the meridional SST gradient leads to amplitude magnification of eddy meridional velocity and temperature and their phase consistency, suggesting that synoptic‐scale eddies tend to approach the optimum structure for the baroclinic energy conversion, which is mainly responsible for the SST front‐induced enhancement of storm track activity. In order to estimate the impact of the oceanic front on the maintenance of the near‐surface baroclinicity, further investigation is made by the composite analysis. With the increase in oceanic frontal strength, the near‐surface baroclinicity experiences a slow but strong restoration. The increase in the meridional SST gradient results in the intensification in the cross‐frontal differential sensible heat flux, which can more effectively offset the relaxing effect of the transient eddy poleward heat transport.
THE CHARACTERISTICS OF KARST CAVES DEVELOPMENT IN LIBO, GUIZHOU

Libo is located in the geomorphological slope zone from the Yunnan Guizhou plateau to the karst hill and the karst isolated plain of Guangxi. Karst caves develope very well in the area. The distribution of the karst caves are controlled by the spacial distribution of carbonate rocks in the region, which is shown by the selective features to strata or lithology, and the layered characteristics of the karst caves. The size and the orientation of the karst caves are obviously controlled by fractures and fissures. Based on the forming conditions and the controlling factors on the space distribution and the sedimentary accumulative formations in the caves, the characteristics of the caves development in the area are discussed in this paper. [WT5HZ]