Miracle-dz/UniFAR-FTUs huggingface dataset:
Annual report narrative disclosures, information asymmetry and future firm performance: evidence from Vietnam

PurposeThis paper examines the role of the annual report’s linguistic tone in predicting future firm performance in an emerging market, Vietnam.Design/methodology/approachBoth manual coding approach and the naïve Bayesian algorithm are employed to determine the annual report tone, which is then used to investigate its impact on future firm performance.FindingsThe study finds that tone can predict firm performance one year ahead. The predictability of tone is strengthened for firms that have a high degree of information asymmetry. Besides, the government’s regulatory reforms on corporate disclosures enhance the predictive ability of tone.Research limitations/implicationsThe study suggests the naïve Bayesian algorithm as a cost-efficient alternative for human coding in textual analysis. Also, information asymmetry and regulation changes should be modeled in future research on narrative disclosures.Practical implicationsThe study sends messages to both investors and policymakers in emerging markets. Investors should pay more attention to the tone of annual reports for improving the accuracy of future firm performance prediction. Policymakers should regularly revise and update regulations on qualitative disclosure to reduce information asymmetry.Originality/valueThis study enhances understanding of the annual report’s role in a non-Western country that has been under-investigated. The research also provides original evidence of the link between annual report tone and future firm performance under different information asymmetry degrees. Furthermore, this study justifies the effectiveness of the governments’ regulatory reforms on corporate disclosure in developing countries. Finally, by applying both the human coding and machine learning approach, this research contributes to the literature on textual analysis methodology.
Aberrantly ASF1B Promotes Proliferation and Metastasis of Lung Adenocarcinoma in Vitro Study

ASF1A and ASF1B are two isoforms of the histone H3–H4 chaperone anti-silencing feature 1 (ASF1) found in mammalian cells. To date, however, it remains elusive if they have different physiological functions in lung adenocarcinoma. Here, we identified both ASF1A and ASF1B are elevated in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). ASF1B, but not ASF1A is associated with poor clinical outcomes and act as an independent prognostic factor in LUAD. In vitro studies, knockdown of ASF1B inhibits the proliferation of lung adenocarcinoma through modulating the expression of cyclins and CDK inhibitor (CKI). Moreover, by restraining epithelial-mesenchymal transition (EMT), abnormal of ASF1B could limit metastasis of lung adenocarcinoma. In summary, ASF1B is important in the development of NSCLC and can provide a novel target for lung cancer therapy.
Design of a Multimodal Imaging System and Its First Application to Distinguish Grey and White Matter of Brain Tissue. A Proof-of-Concept-Study

Multimodal imaging gains increasing popularity for biomedical applications. This article presents the design of a novel multimodal imaging system. The centerpiece is a light microscope operating in the incident and transmitted light mode. Additionally, Raman spectroscopy and VIS/NIR reflectance spectroscopy are adapted. The proof-of-concept is realized to distinguish between grey matter (GM) and white matter (WM) of normal mouse brain tissue. Besides Raman and VIS/NIR spectroscopy, the following optical microscopy techniques are applied in the incident light mode: brightfield, darkfield, and polarization microscopy. To complement the study, brightfield images of a hematoxylin and eosin (H&E) stained cryosection in the transmitted light mode are recorded using the same imaging system. Data acquisition based on polarization microscopy and Raman spectroscopy gives the best results regarding the tissue differentiation of the unstained section. In addition to the discrimination of GM and WM, both modalities are suited to highlight differences in the density of myelinated axons. For Raman spectroscopy, this is achieved by calculating the sum of two intensity peak ratios (I2857 + I2888)/I2930 in the high-wavenumber region. For an optimum combination of the modalities, it is recommended to apply the molecule-specific but time-consuming Raman spectroscopy to smaller regions of interest, which have previously been identified by the microscopic modes.
The development of polycythemia vera after phlebotomy treatment for hereditary haemochromatosis

Hereditary haemochromatosis (HH) is an autosomal recessive disorder, related to mutations in the HFE gene, characterized by increased intestinal iron absorption throughdecreasedhepcidin levels. It is oneof themost common genetic disorders in individuals of European descent and can lead to clinicallymanifest iron overload. In turn, HH can lead to several complications, including diabetes and liver or heart failure [1]. The majority of patients with the myeloproliferative neoplasm (MPN) polycythemia vera (PV), which is characterized by erythrocytosis, harbour a janus kinase 2 (JAK2) mutation [2]. The co-existence of HH and PV is rare. As such, relatively small genetic studies did not reveal HH mutations in a PV population (52 patients) [3], nor were there any significant associations between the occurrence of different haematological malignancies (including 15 PV patients) andHFEmutations [4].
Development and evaluation of pneumatic actuators for pediatric upper extremity rehabilitation devices

Abstract Textile pneumatic actuators were developed to provide full assistance to lift the arm of a model of an 11-year-old male beyond 120 degrees of shoulder abduction. Two fabrics and a variety of sealing techniques, methods of attachment, and actuator shapes were comparatively evaluated using textile and functional tests. The results identified that both fabrics and one of the three sealing techniques were effective for creating air-tight, functional actuators. Actuators were more effective when the bands attaching them were closer to the axilla. Rectangular and wing-shaped actuators, both lifting the model of an 11-year-old male’s arm above 120 degrees of abduction, were more effective than Y-shaped actuators. Multiple designs and materials may be acceptable for building textile pneumatic actuators to lift the full weight of a child’s arm. Compared to traditional hard robots, soft assistive robots offer key potential benefits related to comfort, aesthetics, weight, bulk, and cost.
Dissemination of cagA and cagE Virulence Genes Among H. Pylori Strains From Sudanese Patients With Gastric Discomfort

ObjectivesHelicobacter pylori cytotoxin-associated gene pathogenicity island (cag-PAI) is one of the strain-specific genes (they do not exist in all strains). cag-PAI is involved in inducing inflammation, ulceration, and carcinogenesis. This study aimed to detect and characterize cagA and cagE virulence genes among H. pylori strains from Sudanese patients with gastric discomfort.ResultOut of 288 gastric biopsies screened for the presence of H. pylori, 34% (98/288) were positive, cagA gene was present in 41% (40/98) of specimens, mostly in patients with gastritis 72.5% (29/40), followed by duodenal ulcer 15% (6/40), esophagitis 5% (2/40), and 7.5% (3/40) in patients diagnosed normal by endoscopy. cagE gene was present in 39% (38/98) of specimens, the majority 73.7% (28/38) were from patients with gastritis, 10.5% (4/38) duodenal ulcer, 5.3% (2/38) esophagitis, 2.6% (1/38) gastric ulcer, and 7.9% (3/38) were diagnosed as normal. The cagA and cagE protein sequences have synonymous amino acid variations.
ENRIQUECIMENTO COM ÁCIDOS GRAXOS DA SÉRIE ÔMEGA 3 VISANDO ALIMENTOS MAIS SAUDÁVEIS: REVISÃO

The omega-3 series polyunsaturated fatty acids are widely recognized as essential nutrients for humans, as they exert a variety of health benefits through their molecular, cellular and physiological action. They are considered essential for the normal growth and development of the human body, as they are not synthesized in the body, which can be supplied through the diet. Changes in the diet profile over the years have led to an imbalance between the consumption of fatty acids in the omega-6 and omega-3 series by the population. Reducing the omega-6 / omega-3 ratio would be ideal, since this imbalance is associated with several physiological diseases. A lower omega-6 / omega-3 ratio can be achieved by increasing the consumption of omega3. Considering the physiological effects attributed to these fatty acids, by enriching eggs and meat, which are the main sources of protein and indicated in healthy diets, with omega-3, they can help even more in the promotion of health. A reduction in the omega-6 / omega-3 ratio is expected in the final product intended for the consumer, a higher content of eicosapentaenoic acid and docosahexaenoic acid and an improvement in the quality of meat and eggs. This review aims to address the enrichment of meat and eggs with fatty acids of the n-3 series, as well as their benefits for human health. The consumption of food containing these substances will be in the future an alternative for both producers and consumers.
Detection of SFTS Virus RNA and Total Antibodies in Wild Animals, Jiangsu, China, 2014-2019

Background Severe fever with thrombocytopenia syndrome (SFTS) is a novel infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV). Currently, SFTS is endemic to some areas in China, and wild animals are considered to play important roles in the circulation of SFTSV in the environment. Wild animals monitoring for SFTSV has been fulfilled since 2014 in Jiangsu Province. We studied the results of the detection to provide basic data for better diagnosis of wild animals. Methods This research was conducted in Jiangsu Province from 2014 to 2019. Sera of wild animals (Rodents, pheasants and hedgehogs) were collected to detect SFTSV both RNA and total antibodies by qRT-PCR and enzyme-linked immunosorbent assay. Statistical analysis was performed by using SPSS 25.0 (Chicago, IL, USA). Results A total of 95.8% (1298/1355) of the specimens had the same SFTSV RNA and total antibodies detection results. However, there was a significant difference between the detection rates of SFTSV RNA and total antibodies, and the detection consistency was very poor. The detection rate of SFTSV total antibodies was highest in hedgehogs(19.54%). Conclusions SFTSV total antibodies testing was preferred method during wild animals surveillance. Also, hedgehog could be a competent reservoir for SFTSV.
Using Mobile Technology to Enhance College Sexual Violence Response, Prevention, and Risk Reduction Efforts

Abstract Given high rates of sexual violence (SV) perpetrated against college students, campus administrators need to identify and utilize strategies to prevent and reduce the risk of SV before, during, and after violence has occurred. Developments in technology offer easily accessible avenues for colleges to deliver accurate resources to students in real time. The present study describes the iterative development process that engaged campus administrators, rape crisis center advocates, law enforcement, and students in the development of the mobile application (app), uSafeUS®. Unlike other college safety apps, uSafeUS provides primary prevention by facilitating users safe exit from potentially dangerous situations, secondary prevention by enabling the user to secure help when SV occurs, and tertiary prevention that enables users to obtain resources to help themselves or a friend in the aftermath of SV, all in one place.
Electro-mechanical and mechano-electrical interactions in healthy and drug-induced LQTS rabbit hearts

Type of funding sources: Foundation. Main funding source(s): German Research Foundation Electrical and mechanical heterogeneities and their interactions (electro-mechanical and mechano-electrical coupling; EMC / MEC) are essential for normal cardiac function. Alterations in these can result in increased arrhythmia formation. With this study, we aim to investigate EMC and MEC under physiological and pathological conditions to better understand their roles in arrhythmia development. Multi-channel ECG and TPM-MRI were used to measure regional differences in EMC in healthy ("control") and IKr-blocker E-4031 induced acute LQTS ("E-4031") rabbit hearts in vivo. MEC was studied in both groups by acutely changing mechanical function (increased preload by 6 ml/kg BW bolus of NaCl). In acute LQTS hearts (E-4031 10µg/kg bolus + 1µg/(kg*min) iv), cardiac repolarization was markedly prolonged compared to healthy controls, (p < 0.0001; n = 13), with increased QT-dispersion (Max-Min), a marker for regional heterogeneity of repolarization (p < 0.01; n = 13). Changing electrical function by E-4031 resulted in changes of mechanical features (EMC): in acute LQTS hearts, diastolic longitudinal velocity (Vz) was reduced in all basal (p = 0.003; n = 19) and 4/6 mid segments (p = 0.006; n = 19). Longitudinal diastolic TTP was prolonged significantly in 5/6 basal and 4/6 mid segments by E-4031. These alterations led to an increased apicobasal heterogeneity of longitudinal contraction duration (basal-apical Vz_dia_TTP [ms] 2.9 ± 10.6 vs. 21.1 ± 21.3; p = 0.01; n = 9). Increased preload acutely prolonged QTc in both "control" and "E-4031" hearts (‘control’ 156.6 ± 11.6 to 198.3 ± 20.3; p < 0.0001 vs. ‘E-4031’ 193.9 ± 19.6 to 256.0 ± 37.5; p < 0.0001; n = 13) (MEC). This effect was more pronounced in "E-4031" acute LQTS hearts than in healthy hearts (Figure 1; delta QTc [ms] ‘control’ 41.6 ± 14.9 vs. ‘E4031’ 62.1 ± 32.1; p < 0.006, n = 13). QT-dispersion (Max-Min) was increased significantly upon mechanical change only in "E-4031" (‘E-4031’ 25.8 ± 5.5 to 32.7 ± 12.3; p < 0.03, n = 13). E-4031-induced changes in electrical function resulted in marked alterations in mechanical features via EMC. Similarly, acute changes in mechanical function (increased preload) resulted in electrical changes via MEC. Importantly, QT-prolonging effects of acutely increased preload, as well as its effects on regional heterogeneity of repolarization, were more pronounced in E-4031-induced acute LQTS hearts, indicating that cardiac repolarization in LQTS may be more susceptible to acute MEC effects than in healthy hearts. Acute MEC effects may thus play an additional role in LQT-related arrhythmogenesis. Abstract Figure.
, genetic basis of disease and functional genomics OP0014 HLA ASSOCIATIONS IN PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS ASSOCIATED UVEITIS AND CLINICAL SUBTYPES

Background: Males and females have altered immune responses resulting in variation in autoimmune and cardiovascular disease risk (CVR). Recently, these differences have played a role in the inflammatory response to COVID-19. Sex differences exist in the frequency and activity of immune-cell subsets but mechanisms underlying sexual dimorphism remain unknown. Juvenile-onset systemic lupus erythematosus (JSLE) is an autoimmune disorder that commonly emerges during puberty, has a strong female prevalence (female:male ratio, 4.5:1) and results in an increased CVR. JSLE is characterised by chronic inflammation and dyslipidaemia, where cardiovascular disease is a leading cause of mortality for patients. Our previous work identified a link between immune cell function and lipid metabolism in adult-onset SLE. We hypothesised that sex hormones could influence both lipid metabolism and immune cell function and this could determine sex-specific susceptibility to JSLE and associated CVR. Objectives: We investigated the role of sex hormones in modifying systemic lipid metabolism and inflammation. Methods: Nuclear magnetic resonance spectroscopy based serum metabolomics measuring over 130 lipoproteins (14-subsets with lipid compositions), flow cytometry measuring immune-cells, and RNA-sequencing were used to assess the metabolic and immune profile in young, pre/post-pubertal males (n = 10/17) and females (n = 10/23) and in individuals with gender-dysphoria (GD) under cross-hor-mone treatment (trans-male/female, n = 26/25). This analysis was also performed on a cohort of post-pubertal male (n = 12) and female (n = 23) JSLE
Improving the Design of Ambient Intelligence Systems: Guidelines Based on a Systematic Review

ABSTRACT Ambient intelligence (AmI) emerged in Europe with the idea that the computational support available in a living environment can help people’s lives. AmI introduces new challenges and critical issues because this technology differs from the traditional form of interaction that is centered on a device or system. In this work, we aim to contribute to this topic by conducting a systematic literature review in order to identify Human-Computer Interaction guidelines for the design of ambient intelligence systems. We found a total of 120 guidelines from 27 papers, and we grouped similar guidelines creating different categories. These categories of guidelines later became a unified guideline incorporating also some of our own ideas. As a result, this paper identifies ten categories and guidelines to improve user interaction with ambient intelligence systems. We believe that these guidelines significantly contribute to designing more intuitive AmI systems for users, including those with disabilities.
Role of occupational therapy in rehabilitation of cancer patients

INTRODUCTION Most adult cancer survivors report a significant decrease of their quality of life (QoL) and limitations in performing basic activities of daily living (ADLs) and/or instrumental activities of daily living (IADLs), some that are due the cancer itself, while some are the result of treatment-related side effects or age-related functional decline. Overall, a cancer patient has a higher risk of developing a long-term disability and is more susceptible to institutionalization and has an increased mortality risk
The evolution of latitudinal ranges in reef‐associated fishes: Heritability, limits and inverse Rapoport's rule

Variation in the size and position of geographical ranges is a key variable that underlies most biogeographical patterns. However, relatively little is known in terms of general principles driving their evolution, particularly in the marine realm. In this study we explore several fundamental properties regarding the evolution of reef fish latitudinal ranges, namely the degree of similarity in range size between ancestor and descendant lineages (i.e. phylogenetic signal); the evolution of range limits; and the latitudinal distribution of range sizes, particularly with respect to Rapoport's rule.
Characterization and Valorization of Dietary Fibre Concentrate from Parthenocarpic Date Fruits

Parthenocarpic date fruits are good sources of antioxidant and fibre, which could be changed into valuable by-products. There is no attempt to use it in technological processes and could provide a natural additive to enhance the quality of the product. In this study, fibre concentrate from partenocarpic dates (FCPD) was extracted, dried, and characterized. Two drying techniques, namely oven and freeze drying, were carried out, and then the FCPD were characterized. Thereafter, its ability to substitute flour in muffins was studied. The freeze-drying gave the highest yield of FCPD revealing lignin richness but cellulose and hemicellulose insufficiency. Drying techniques gave similar FCPD WHC and OHC but antioxidant capacity was higher in the case of freeze-dried fibre. Electronic microscopy showed that the more FCPD was introduced in the flour, the more the muffin crumb contained disrupted matrices. This could enhance the muffin freshness by improving the moisture retention. Moreover, although flour substitution by FCPD increased muffin volume and its OHC value, its WHC, moisture, mineral and sugar contents were not affected. Calorific value, phenol content and antioxidant activity were greater in the case of muffins with 5% of freeze-dried FCPD. Sensory analyses showed that fibre-enriched muffins had good scores as the control ones. In this study, we used oasis raw materials with good source of fibres and antioxidant capacity that could be used in the production of high value-added foods. Additionally, the research demonstrated that freeze-dried FCPD flour fortification enhances the physicochemical characteristics of the muffin. The parthenocarpic date fruits is an agricultural residue with interested chemical and functional properties that could be undertaken in food process industries.
Sleep disorders in adolescent school children in Kochi: a cross sectional study

Sleep disorders are common in adolescents but are often under recognized and their implications are often neglected. About a fifth of children and adolescents have sleep disorders of diverse aetiology which can disrupt their quality of life. Sleep deprivation in Adolescents can have negative outcomes like poor academic performance, mood and behaviour changes, substance abuse and accidents. Studies on sleep patterns in school going adolescents from Delhi, India showed higher incidence of daytime sleepiness and sleep deprivation in adolescents and its deleterious effects on academic performance and their self-esteem.
Multiple Control Assistive Wheelchair for Lower Limb Disabilities & Elderly People

This article presents a multiple control wheelchair to help individuals with lower-limb disabilities using advanced assistive technologies. A new control methodology of a multiple-controlled wheelchair (MCW) has been given here. The main feature of this assistive device is that it can navigate by following the user's eyesight. The proposed MCW can also be controlled using either joystick or the internet or a combination of all. This system uses multiple sensor networks to measure the terrain condition; users command and translate it into control action. The proposed control system runs on a Raspberry Pi, which can take an accurate turn and capable of controlling forward or backward motion. Raspberry Pi, camera module and sensors networks, etc., were all connected to the android mobile system, shortening the physical distance between the disabled person end and the supervisor end, and serial communication is used. Multiple-Layer system architecture with special control functions is built that uses android mobile interfacing to realize the automatic control and capture videos of the surrounding environment remotely. It is shown that the users can carry out all essential tasks with more control actions which improve the quality of traditional wheelchair.
The rising water level in Lake Van : environmental features of the Van basin which increase the destructive effect of the disaster

Lake Van, the largest in Turkey and fourth largest in the world is situated in a closed basin. The water level in Lake Van has increased by about four metres since the mid sixties causing serious environmental damage. It is known that this problem does not only pertain to Eastern Anatolia, but changes in water levels of lakes in Iran and Azerbaijan are also being observed. Thus, the problem seems to be regional rather than local. Research was conducted in order to evaluate the existing physical features of the Van Basin and to develop a proposal for allocation of the Van residents which are under flood threat. This paper presents the general features of the basin associated with water fluctuations and evaluates thesettlement condition relative to the change in the lake water level.