Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of strategies to recruit and retain older people with dementia and their informal carers into a Tai Chi Trial to improve balance and prevent falls

Abstract Objectives: Randomised control trials (trials) involving people with dementia lack detailed analysis of recruitment and retention strategies. To address this, we examined the effectiveness of strategies in “The TACIT Trial: TAi ChI for people with demenTia” Methods: We recruited dyads (people with dementia and carers) from 3 South of England sites utilising different strategies. Recruitment strategy effectiveness was measured by percent yield (number randomised of total referrals) and cost per randomised participant. Our retention strategy (maintaining contact with participants during weekly telephone calls) was measured by percent yield (number retained by six-month follow-up). Results: Of 359 dyads, 24% were randomised into the study (n=85). The most resource-intensive strategy (research nurses spending 30 minutes explaining the study) had the highest referral to randomisation rate. An incremental cost-effectiveness ratio suggested an alternative approach (nurses and doctors spending 5 minutes explaining the study) was most cost-effective. Retention rates were 86% (n=36/42; intervention group) and 81% (35/43; control group); main reasons for attrition were worsening health and lack of study interest. Conclusions: The results demonstrate person-centred strategies enabling staff to spend time with participants were effective in supporting recruitment and retention. Those designing future trials must consider such strategies and the associated costs.
MUFF: A Low-cost Motorized Positioner Developed by Additive Manufacturing to Obtain Multi-focus Images

Multifocal microscopy is an established technique to combine several reflected-light microscopy images of an object, each with a limited depth of focus, into a single image that shows the whole object in focus. Photometric stereo is an independent technique to recover the third dimension of an opaque object, given several images taken from the same viewpoint with different illumination conditions. We describe a low-cost motorized positioning device for the automatic acquisition of multiple reflected-light low-power microscope images of an object for combined multifocal and photometric stereo capture of millimeter-scale objects. The device automatically varies the microscope-to-object distance and the light direction, under control of an Arduino microcontroller. The device consists of a supporting frame, a microscope holder with motorized vertical displacement, an illumination stage with multiple light sources, and control electronics. The mechanical and structural parts are largely 3D-printed. The electronics is based on the Arduino microcontroller. The device is driven through an USB cable by a Python program that runs on a PC.
The DNA Damage Response in Fully Grown Mammalian Oocytes

DNA damage in cells can occur physiologically or may be induced by exogenous factors. Genotoxic damage may cause cancer, ageing, serious developmental diseases and anomalies. If the damage occurs in the germline, it can potentially lead to infertility or chromosomal and genetic aberrations in the developing embryo. Mammalian oocytes, the female germ cells, are produced before birth, remaining arrested at the prophase stage of meiosis over a long period of time. During this extensive state of arrest the oocyte may be exposed to different DNA-damaging insults for months, years or even decades. Therefore, it is of great importance to understand how these cells respond to DNA damage. In this review, we summarize the most recent developments in the understanding of the DNA damage response mechanisms that function in fully grown mammalian oocytes.
A hyper elastic conductor for bulk energy transfer in the wall of spoolable tubes for electric deep drilling

VII KURZFASSUNG . XI 1 PROBLEM STATEMENT . 1 2 STATE OF KNOWLEDGE. 3 2.1 DRILLING TECHNOLOGIES . 3 2.1. 1 Problems of conventional rotary drilling . 4 2.1. 2 Steel coiled tubing – applications and limitations. 6 2.1. 3 Scenario of a new Power and Data Transmitting coiled tubing technology advantages and challenges. 8 2.1. 4 PDT-COIL specifications and derived requirements for the electric system . 10 2.1. 5 Key problem – high mechanic strain in the tube wall of the PDT-COIL tube . 12 2.2 MECHANIC AND ELECTRIC BEHAVIOUR OF ELECTRIC CONDUCTORS EXPOSED TO CYCLIC STRAIN . 14 2.2.1 Theory on buckling and cyclic strain . 15 2.2.2 Low cycle fatigue properties of electric conductor materials . 21 2.2.3 Mechanics of strands and wire ropes. 25 2.2.4 Influence of mechanic strain on the electric resistance of conductors. 27 2.2.5 Influence of high strain on the dielectric integrity of cable insulation materials . 29 2.3 REVIEW ON SOLUTIONS FOR ELECTRIC ENERGY TRANSFER UNDER INCREASED MECHANIC LOAD REQUIREMENTS . 32 2.3. 1 Electric energy transfer in tube walls of spoolable tubes. 32 2.3. 2 Solutions for electric energy transfer with axial elasticity . 35 2.3. 3 Electric cables designed for high bending fatigue life . 38 2.3. 4 Electric cables exposed to high bending and axial loads. 41 2.4 DETERMINATION OF THE ELECTRIC POWER TRANSFER CAPABILITY . 43 2.4.1 Limitations of the electric power transfer in cables . 43 2.4. 2 Temperature distribution in boreholes. 44 2.5 CONCLUSIONS ON THE STATE-OF-THE-ART . 45 3 RESEARCH GOALS . 47 4 DETERMINATION OF THE ACHIEVABLE BENDING CYCLES WITH CONVENTIONAL ELECTRIC CABLES. 49 4.1 DESIGN OF TESTED CABLE PROTOTYPES. 49
Chromatin Remodeler Smarca5 Is Required for Cancer-Related Processes of Primary Cell Fitness and Immortalization

Smarca5, an ATPase of the ISWI class of chromatin remodelers, is a key regulator of chromatin structure, cell cycle and DNA repair. Smarca5 is deregulated in leukemia and breast, lung and gastric cancers. However, its role in oncogenesis is not well understood. Chromatin remodelers often play dosage-dependent roles in cancer. We therefore investigated the epigenomic and phenotypic impact of controlled stepwise attenuation of Smarca5 function in the context of primary cell transformation, a process relevant to tumor formation. Upon conditional single- or double-allele Smarca5 deletion, the cells underwent both accelerated growth arrest and senescence entry and displayed gradually increased sensitivity to genotoxic insults. These phenotypic characteristics were explained by specific remodeling of the chromatin structure and the transcriptome in primary cells prior to the immortalization onset. These molecular programs implicated Smarca5 requirement in DNA damage repair, telomere maintenance, cell cycle progression and in restricting apoptosis and cellular senescence. Consistent with the molecular programs, we demonstrate for the first time that Smarca5-deficient primary cells exhibit dramatically decreased capacity to bypass senescence and immortalize, an indispensable step during cell transformation and cancer development. Thus, Smarca5 plays a crucial role in key homeostatic processes and sustains cancer-promoting molecular programs and cellular phenotypes.
OPTH_A_345403 531..540

Purpose: We conducted a systematic review to investigate the effectiveness of clinical treatments for wet age-related macular degeneration (wAMD) in Japanese patients in the decade since anti-vascular endothelial growth factor (VEGF) therapies were introduced. Methods: PubMed was searched for articles published in English between 1 January 2008 and 30 September 2018 using a multistring search strategy. Reviews were scanned for additional relevant studies and select gray literature was evaluated. Mean and/or median for the logarithm of the minimum angle of resolution (logMAR) visual acuity (VA), central retinal thickness (CRT), and the number of injections after 12 months of treatment were calculated using extracted data. Data were stratified by disease type and treatment modality. Results: Of 335 studies identified, 94 were selected for data extraction (147 treatment arms; typical AMD, n = 25; polypoidal choroidal vasculopathy [PCV], n = 85). Mean (median) logMAR VA was 0.44 (0.32) for typical AMD and 0.34 (0.31) for PCV; the respective mean number of anti-VEGF injections was 5.6 and 4.6. The mean CRT was approximately 220 μm for both groups. For typical AMD, anti-VEGF monotherapy resulted in better VA outcomes than photodynamic therapy (PDT) alone. For PCV, anti-VEGF monotherapy or anti-VEGF plus PDT combination therapy resulted in better VA and CRT outcomes than PDT monotherapy. Combination therapy required fewer injections than anti-VEGF monotherapy (PCV, 3.2 versus 5.3). Conclusion: wAMD treatment has advanced dramatically in the years since anti-VEGF drugs were introduced in Japan. Discrete patient populations may benefit from differing management regimens, including the fewer injections required with combination therapy.
The Role of Local Government Authorities in Facilitating Community Participation for Small and Medium Tourism Enterprises Growth

Community participation in Small and Medium Tourism Enterprises (SMTEs) has been assumed to be one of the best ways to benefit from tourism sector. However, the persistent problem facing local tourism is how to improve the growth of SMTEs. This study was set to bridge this knowledge gap on the role of local government in supporting Small and Medium Tourism Enterprises. The study objective was to assess the Local Government Authorities role in facilitating community participating in tourism for the SMTEs growth. Guided by stakeholder’s theory, the study followed a quantitative research approach and a cross-sectional survey design. Questionnaires were used to collect data from census of 232 SMTEs owners-managers. The study used multiple linear regressions for data analysis. The study findings indicated that community participation has positive and significance contribution to SMTEs growth in Tanzania. The study concludes that the LGAs’ role in facilitating tourism is partially contributing to SMTEs growth. This could be attributed by tourism policy and Act which are not aligned to stipulate the roles of LGAs in local tourism. The most important lesson of the study is that if LGAs in their area of jurisdiction are actively engaged in tourism SMTEs will grow significantly. The study recommended a review of Tourism legal framework so that LGAs part to development process of local tourism
“Sentiments Of Social Media Users, Towards Web Education – A Data Mining Techniques.”

In the 21 st century, the Internet has caused a knowledge explosion, and every day quintillion bytes of data are created. Thus analyzing data and interpreting it has become an arduous task for educators. However, data analysis has become straightforward due to the advent of data mining techniques and machine learning. Recently the Corona Virus pandemic harmed the education system across the World, and the task of imparting education has been shifted from traditional face-to-face education to web education. Websites and social media in teaching and learning have created massive data. It has become a vital source of information for studying social media users' thoughts, emotions, feelings, opinions, and perceptions. Since many social media are available on Internet, this study uses the microblogging Twitter platform for sentiment analysis due its short messages and popularity. In this research, text mining is done using the Open Source Visual Programming Software Orange (3.28.0; Orange Data Mining, n.d.). The text mining technique involves four processes; in the first process, the text is extracted from posts of the Twitter platform; in the second process, the obtained data is pre-processed, and sentiments of Twitter are analyzed with the help of Orange (3.28.0; Orange Data Mining, n.d.) software. In the third step, the classification of sentiments is done using the V.A.D.E. R. (Valence Aware Dictionary and Sentiment Reasoner) modules. Finally, the obtained scores from text mining are used to analyze data. The research findings suggest that Twitter users' sentiments have moderate positive compound sentiment (.389) about web education and the use of technology in education. Further, the compound polarity scores of 38 % of tweets about web education suggest the tweets were moderately positive and greater than zero. This study's moderate positive compound sentiments are due to the shift from traditional face-to-face (f2f) education to Web-based education during the pandemic. The educators, schools, colleges, and universities emphasized web-based teaching, learning, and evaluation during pandemics.
An Analysis of Current Thyroid Function Test Requests

Background: Unnecessary and excessive Thyroid function testing can lead to added economic burdens in an era of rising healthcare costs, whilst only minimally having any significant clinical benefit. I set out to analyse the current practice at the health centre with comparisons against international guidelines, with a view to reducing patient exposure to unnecessary test and to increase thyroid testing cost efectiveness. Methods: A record of all Thyroid Function Test (TFT) requests was extracted from electronic medical records, over the period of November 2019 and a random sample of 100 patients was further analysed to assess indications for testing. Results: A thorough and detailed analysis showed that for 20/100 of patients a valid justification was found in terms of patients presenting with symptoms suggestive of thyroid disease (Diagnosis). A further 7/100 sample had a known thyroid disease and were being appropriately tested (Monitoring). 16/100 patients were correctly tested for associated conditions (Screening). Overall, there was a valid justification for 43% of the 100 Random Sample analysed. Conclusion: In summary I found thatinappropriate requesting of thyroid function tests is common. In an era of rising healthcare costs, inappropriate thyroid function testing is an ideal target for efforts to reduce laboratory over utilization
Role of Solar & Atmospheric Disparity on Climate of Western India,Kota, Rajasthan, India

In the last three decades, India has been facing the unusual weather condition that the affects the social-ecological balance. The summers are getting hotter; winters colder, drought, stronger storms, heat waves, floods, cloud burst, cyclones, and anomalous seasonal weather frequency and intensity have been historical expectations. Indian climate is affected by winds coming from the Indian Ocean as well as cold, dry northern winds along with atmospheric Hedley and Farrell cell wind and variation in these atmospheric winds. The change in solar radiation may impact these wind patterns, and extreme climatic events that happened globally. To better understand the impact and trend of solar and atmospheric disparities and associated climatic factors such as mean solar radiation, atmospheric pressure, precipitation, wind speed & wind direction and temperature, on extreme climatic conditions in Western India, selected the confluence area of Hedley and tropical wind. They divert at 30°N -25°N latitude as a variation of ITCZ, would be beneficial to understand the actual reason behind the increasing the extreme climatic condition. The city Kota is situated at 25°N latitude under the state of Rajasthan, India, selected for the study.
Considerations to deal with the frozen cell problem in Tau-Argus Modular.

The package τ Argus is a widely used EU - funded Open Source tool for disclosure control in tabular data. For secondary cell suppression it offers several alternative algorithms, one of which, referred to as “Modular”, is recommended best practice for applic ation to large, complex structured sets of hierarchical and linked tables. Meanwhile, several NSIs and Eurostat have invested into integration of the software into production environments. The issue we mainly address in this paper is an important use case still lacking a sound methodological approach: The usual production process for a statistic involves dissemination of a major set of pre-planned tables as soon as data are available for this production step. Typically, later on, there will be requests from users for specific additional tabulations, often linked to the tables of the already disseminated ones. When protecting such additional tables one has to take into account the suppression pattern of the disseminated tables: Suppressed cells must be suppressed in those new tables as well, and cells already disseminated must not be used as secondary suppression in the additional tables to avoid disclosure risks. However, the latter, sometimes referred to as “frozen cells”, may cause an infeasible problem for the cell suppression algorithm, creating a major obstacle for using τ - Argus in this use case, especially in a widely automated production process. The paper will propose a work around for the infeasibility problem, and explore issues of respective enhancement of the Modular method.
Business Cycles and Earnings Inequality

I construct a novel, quarterly measure of earnings inequality and document the following facts. First, shocks to productivity and government expenditure have significant effects on earnings inequality, while monetary policy shocks have little effect. Second, unanticipated innovations in earnings inequality, summarizing redistributive forces from the bottom to the top, substantially lower aggregate demand in a U-shaped manner. Finally, the power of stabilization policies increases with the level of inequality. These empirical results are rationalized by a tractable two-agent model, featuring countercyclical earnings risk, an endogenous extensive margin of being credit constrained, and decreasing relative risk aversion preferences. Author's contact information
Bicarbonate-indced Fe deficiency effects on essential oil composition of Tunisian aromatic plant: dill (Anethum graveolens L.)

In the present report, A. graveolens shoots were subjected to Fe depeletion conditions and explored for their growth activity and essential oil (EO) composition. For this purpose, plants were cultivated for 14 days in hydroponic medium supplemented or not with 30 μM Fe + CaCO3+10 mM NaHCO3. Under lime Fe deficiency conditions, shoots fresh dry weight were significantly reduced. On the other hand, under the omnipresence of Fe (control conditions), A. graveolens shoots produced a medium essential oil yield. This latter decreased in yield by about 40% under induced Fe deficiency. In parallel, GC/MS analysis showed that, the major constituents under control conditions is camphor, whereas, the major volatile component under Fe depletion is dillapiole. Overall, the tolerance of dill is explained by its aptitude to reduce its growth activity to uphold the nutrient uptake of iron and by the enhancement of dillapiole secretion.
MOVING PROCESSES AND CONDITIONS OF RESIDENTS UNDER THE HOUSING LEASE PROGRAM FOR DISASTER VICTIMS IN SENDAI CITY

Following the Great East Japan Earthquake, the housing lease program for disaster victims supplied over 60,000 private rental houses that serve as temporary housing. The number of houses has exceeded the number of newly constructed units of prefabricated temporary housing and many residents moved to urban areas in order to acquire rental houses. To examine moving processes and living conditions of residents under this program, an interview survey was conducted with residents living in leased houses in Sendai City. The following results were obtained. (1) Residents who were able to acquire housing in the early stage found rental houses with the cooperation of relatives and acquaintances, instead of real estate agents. (2) Many residents were not able to acquire adequate houses for the number of persons in their households. For this reason, families had to live separately. (3) Some residents experienced stress with their new life in rental houses because of the drastic change in their living environment.
Analysis of Caveolin-1 Expression and Interaction with FSHR in Lipid Raft Domains

Bott, Joseph Analysis of Caveolin-1 Expression and Interaction with FSHR in Lipid Raft Domains. Department of Biology, June 2021 ADVISOR: Brian D. Cohen For thousands of women in the United States ovarian cysts, tumors, and hormonal imbalances contribute to reduced fertility and fecundity. In addition to these factors, many other unexplained physiological mechanisms may play a role in women’s reproductive health. Specifically, human follicle stimulating hormone (hFSH) binds to a G protein coupled receptor (GPCR) called human follicle stimulating hormone receptor (hFSHR). This interaction helps to regulate the reproductive system in both males and females indicating that it may be a key player to target in order to promote fertility. Previous work in our lab has demonstrated that hFSHR, like other GPCR, has been shown to preferentially localize within microdomains in the cell membrane known as lipid rafts in order to facilitate proper signaling. This localization is thought to be mediated in part by a protein known as caveolin. In order to investigate the relationship hFSHR and caveolin, a cell line expressing hFSHR (HEK293-hFSHR) was transfected with a plasmid to transiently express caveolin. Immunoprecipitations were used to investigate the interaction between caveolin and full length hFSHR. Western blot analysis was subsequently performed to detect protein interactions. Based on the data generated from this experiment, the previously established relationship between FSHR and lipid raft residency was not confirmed because it was not shown that caveolin co-precipitated with FSHR. These findings may suggest that previous studies used methods that resulted in artifactual phenomenon. However, it is equally possible that the conditions, plasmids, or cells used in these experiments contributed to the inability to replicate the results found previously. Understanding the possible interaction between hFSHR and caveolin is crucial in the future development of therapeutics that will allow us to fine tune receptor function for infertility treatments.
Lecture 14: Cheeger’s Inequality cont., Spectral Clustering

Question: Why aren’t we looking at the mincut as a measure of conductance? Why are we normalizing by the size/volume of S in |E(S,S̄)| vol(S) ? Answer: Consider a network of roads. One road in this network is a highway that connects two major cities. Another is your driveway that connects your house to the rest of the network. If cut either of these roads, it will divide the network into two disconnected sub-networks, so these are two mincuts of our graph each with size 1. However, the two roads have very different levels of conductance. The numbers of drivers inconvenienced by the shutdown of a highway is much greater than those inconvenienced by the shutdown of your driveway.
A Simple 3D Immersed Interface Method for Stokes Flow with Singular Forces on Staggered Grids

In this paper, a fairly simple 3D immersed interface method based on the CG-Uzawa type method and the level set representation of the interface is employed for solving three-dimensional Stokes flow with singular forces along the interface. The method is to apply the Taylor’s expansions only along the normal direction and incorporate the jump conditions up to the second normal derivatives into the finite difference schemes. A second order geometric iteration algorithm is employed for computing orthogonal projections on the surface with third-order accuracy. The Stokes equations are discretized involving the correction terms on staggered grids and then solved by the conjugate gradient Uzawa type method. The major advantages of the present method are the special simplicity, the ability in handling the Dirichlet boundary conditions, and no need of the pressure boundary condition. The method can also preserve the volume conservation and the discrete divergence free condition very well. The numerical results show that the proposed method is second order accurate and efficient. AMS subject classifications: 65M06, 76D07