Miracle-dz/UniFAR-FTUs huggingface dataset:
Prior Resection of the Primary Tumor Prolongs Survival After Peptide Receptor Radionuclide Therapy of Advanced Neuroendocrine Neoplasms.

MINI: The role of resection of primary tumors in patients with advanced neuroendocrine neoplasms is still unclear. We investigated 2 groups of patients treated using peptide receptor radionuclide therapy (PRRT; mean of 4 cycles PRRT) with and without a prior primary tumors resection. Surgical resection resulted in a significantly prolonged overall- and progression-free survival.This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 OBJECTIVE:: The aim of the study was to compare impact on survival after resection of primary tumors (PTs) after peptide receptor radionuclide therapy (PRRT). BACKGROUND PRRT is a highly effective therapeutic option to treat locally advanced or metastatic neuroendocrine neoplasms (NENs). METHODS We retrospectively analyzed the data of 889 patients with advanced NEN (G1-G3, stage IV) treated with at least 1 cycle of PRRT. In 486 of 889 patients (55%, group 1), PT had been removed before PRRT. Group 2 constituted 403 patients (45%) with no prior PT resection. Progression-free survival was determined by Ga SSTR-PET/CT in all patients applying RECIST and EORTC. RESULTS Most patients had their PT in pancreas (n = 335; 38%) and small intestine (n = 284; 32%). Both groups received a mean of 4 cycles of PRRT (P = 0.835) with a mean cumulative administered radioactivity of 21.6 ± 11.7 versus 22.2 ± 11.2 GBq (P = 0.407). Median OS in group 1 was 134.0 months [confidence interval (CI): 118-147], whereas OS in group 2 was 67.0 months (CI: 60-80; hazard ratio 2.79); P < 0.001. Likewise, the median progression-free survival after first PRRT was longer in group 1 with 18.0 (CI: 15-20) months as compared to group 2 with 14.0 (CI: 15-18; hazard ratio 1.21) months; P = 0.012. CONCLUSIONS A previous resection of the PT before PRRT provides a significant survival benefit in patients with NENs stage IV.This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0.
Characteristics of patients with cleft lip and palate during the community services in East Nusa Tenggara, Indonesia, 2017-2018

Background: Cleft lip and palate is a congenital abnormality that occurs early in during embryonic development. This disorder can cause speech, hearing, malnutrition and mental and social development disorders. The prevalence of cleft lip and palate in the world varies greatly, with the highest incidence rate in Asia. Purpose: This research aims to determine the characteristics of patients with cleft lip and palate during the community services in East Nusa Tenggara, Indonesia, from 2017 to 2018. Methods: The type of research is descriptive research with a population of 48 patients who attended the community service event for cleft lip and palate surgery. Patient data characteristics were grouped based on age, gender, and cleft lip and palate type. Results: The distribution of patients with cleft palate was mostly aged 0-5 years (47%), the gender was the same between men and women (50%), and the most common type of cleft palate was cleft of the anterior (primary) palate (54%). Conclusion: Understanding cleft lip and palate patients in East Nusa Tenggara helps determine incidence rates and risk factors. This helps in customizing services, facilitating educational efforts, and involving the local government for effective community support.
Swimming Performance of Schizothorax sp. and Planning of Fish Passages in Nepal

Swimming performance of migrating fish is crucial for the planning and design of effective fish passages. Commonly the fish swimming speeds are classified into five categories: 1) Optimum Swimming Speed, 2) Maximum Sustained Swimming Speed, 3) Critical Swimming Speed, 4) Maximum Domed Swimming Speed, and 5) Burst Swimming Speed. Swimming characteristics are related to the different species' adaptions to the environmental conditions. A variety of different factors affect the swimming capacity of fish which is directly related to fish size and species-specific morphology. A crucial abiotic factor is water temperature, which affects the fish physiology and thereby the swimming speed of the fish. This means that the fish's swimming speed can increase with increased water temperature. The swimming speed also increases with fish size. Fish often use burst speeds when passing a step in a fish ladder or entering a culvert. Burst speed is the highest speed attainable for fish, and it is the maximum energy output to be gained by using the white muscle (red muscle in salmonids). The burst speed can only be maintained for short periods of time (seconds). In the Himalayas, the main objective of many fisheries development plans is to secure future habitats and ensure up- and downstream migration of fish. Schizothorax richardsonii is often a targeted species in the area due to its importance as a food resource. If a fish passage is prepared for the upstream migration of fish, it is also crucial for the fish population development to ensure a safe downstream passage. Data on swimming performance for many of the native fish species in Nepal are scarce which complicates the design of suitable ecologically adapted fishways. In general, nature-like fish passes allow most of the species to migrate, followed by vertical slot fishways, meander fishways, and thereafter fish ladders of the pool-and-weir type. The key factor is to construct fish-passes that under all naturally required environmental circumstances can allow appropriate passage conditions of the targeted fish species.
An efficient swarm intelligence approach to the optimization on high-dimensional solutions with cross-dimensional constraints, with applications in supply chain management

Introduction The Swarm Intelligence Based (SIB) method has widely been applied to efficient optimization in many fields with discrete solution domains. E-commerce raises the importance of designing suitable selling strategies, including channel- and direct sales, and the mix of them, but researchers in this field seldom employ advanced metaheuristic techniques in their optimization problem due to the complexities caused by the high-dimensional problems and cross-dimensional constraints. Method In this work, we introduce an extension of the SIB method that can simultaneously tackle these two challenges. To pursue faster computing, CPU parallelization techniques are employed for algorithm acceleration. Results The performance of the SIB method is examined on the problems of designing selling schemes in different scales. It outperforms the Genetic Algorithm (GA) in terms of both the speed of convergence and the optimized capacity as measured using improvement multipliers.
Radiolarian Fauna and Geochemical Characters of the Cherts from Garz-Litang Tectonic Belt and Its Tectono-Paleogeographic Significance

The Upper Triassic Hagong Formation distributed in the Shangri-La area,northwestern Yunnan consists of terrestrial conglomerate,sandstone,siltstone,and mudstone,in which a great number of chaotic blocks were developed.The Chert chaotic blocks yield Middle Devonian to Middle Triassic radiolarian fauna,as well as Middle Devonian tantaculites.All the chert chaotic blocks with various ages are biogenic with Al2O3/(Al2O3+Fe2O3) ratios from 0.58 to 0.96. NASC normalized REE patterns for the cherts are relatively flat with weak negative or obvious positive Ce anomaly and no Eu anomaly,which implies the continental margin basin of depositional environment.The plankton assemblage of radiolarian and tentaculites and the geochemical features indicate that the Garz-Litang basin should have formed before Middle Devonian.The evolution of Garz-Litang basin could be divided into two stages according to the REE characters,slowly spreading stage from Middle Devonian to early Early Carboniferous and fast spreading and subduction stage from late Early Carboniferous to Middle Triassic.The basin provided a deep-water sedimentary environment in Late Triassic,even Jurassic.
Displacement, disempowerment and corruption: challenges at the interface of fisheries, management and conservation in the Bijagós Archipelago, Guinea-Bissau

Abstract Small-scale fishers working in the West African Bijagós Archipelago are predominantly regional in-migrants, often living in isolated fishing camps (or economic enclaves) where capture, processing and trading activities occur. This paper explores the factors driving the fishing camp formation, relations with non-camp communities and interactions with prominent authority groups. One camp, presented here in the context of an anthropological case study, lost access to Ancopado beach during the designation of Orango National Park. Following violent evictions, migrant fishers shifted their efforts into less-observed waters, introducing challenging power negotiations with indigenous Bijagós islanders and fisheries authorities. Fishing persists inside the marine protected area, indicative of non-compliance by small-scale fishers who continue to resist a weak resource management agenda. The implications of this situation are discussed in terms of human rights to fish.
Operational Risk Management (ORM) as an Approach to Optimize Sustainability in the Construction Industry

In the contemporary domain, sustainable construction projects are growing in the market with advanced standards. With the application of new materials and technology in construction, there has been an exponential surge in risks. The significance of risk administration in optimizing sustainability in construction ventures is, therefore, augmenting. This thesis assignment was aimed at expanding insights into project-related operational risks in the construction sector and their management. It was requisite to get familiar with good practices in the sector to suggest effective recommendations relating to the topic. The thesis examined operational risk management (ORM) as an approach to optimize sustainability in the construction industry. The thesis assumed an archival study and secondary analysis to construe the study hypothesis. Data gathering utilized both primary and secondary approaches. The questionnaire was used to reinforce the research outcomes. Data analysis involved categorization using a network of relationships. The results from 10 articles sampled in the study indicated that while most actors in the construction sector understand the importance of risk management, the role played by ORM in improving sustainability is not widespread.
Stratigraphic position and sedimentary features of the Tertiary Uppermost Fluvial Member in the Kleszczów Graben, central Poland

Pozycja stratygraficzna i cechy sedymentologiczne trzeciorzedowej najwyzszej serii fluwialnej w rowie Kleszczowa, Polska środkowa The Uppermost Fluvial Member of the Neogene sequence of the Kleszczow Graben represents a thick sand body which was deposited by a "threshold" river, with some characteristics of sinuous rivers, though with no point bars and limited overbank deposition. Dominating lithofacies are very large-scale troughs, up to 6 m deep and 25 m wide. These troughs represent palaeochannels, which have been filled with large- and medium-scale cross bedded sands and less common thin and discontinuous fine sands, clayey-silt or peat/organic mud and clay lenses. The sandy material comes mainly from the redeposition of the underlying older Neogene deposits, and locally from Jurassic sands from the graben margins. The age of the member is late Middle Miocene to Upper Pliocene, and pollen analysis has indicated thermophilous forest (late Middle Miocene) at the lower and middle parts of the series and relatively cooler conditions, though still with forest (late Pliocene) in the uppermost part of the series. Formation of the Uppermost Fluvial Member was tectonically controlled. At first it is because of the unexpected sedimentary environment and formation of a sand body despite dense vegetation cover. On the other hand, the Uppermost Fluvial Member represents the lower part of the youngest sedimentary mega-cycle of the Neogene sequence in the Kleszczow Graben, which is interpreted as entirely tectonically controlled sedimentary sequence.
Images, Words, and Imagination: Accessible Descriptions to Support Blind and Low Vision Art Exploration and Engagement

The lack of accessible information conveyed by descriptions of art images presents significant barriers for people with blindness and low vision (BLV) to engage with visual artwork. Most museums are not able to easily provide accessible image descriptions for BLV visitors to build a mental representation of artwork due to vastness of collections, limitations of curator training, and current measures for what constitutes effective automated captions. This paper reports on the results of two studies investigating the types of information that should be included to provide high-quality accessible artwork descriptions based on input from BLV description evaluators. We report on: (1) a qualitative study asking BLV participants for their preferences for layered description characteristics; and (2) an evaluation of several current models for image captioning as applied to an artwork image dataset. We then provide recommendations for researchers working on accessible image captioning and museum engagement applications through a focus on spatial information access strategies.
The Impact of Different Patterns of Residual Disease on Long-Term Oncological Outcomes in Breast Cancer Patients Treated with Neo-Adjuvant Chemotherapy

Simple Summary We investigated the predictive factors for different patterns of residual disease in the breast after neo-adjuvant chemotherapy and compared the long-term outcomes between the scattered versus the circumscribed pattern. A total of 219 histologic sections of postoperative surgical specimens were evaluated. Two independent predictive factors for the circumscribed pattern were identified: discontinuation of neo-adjuvant chemotherapy cycles and a tumor size >18 mm. Over a median follow-up of 74.7 months, disease-free survival and distant disease-free survival rates were similar for both patterns; however, the scattered pattern showed significantly better overall survival. Additionally, four independent factors associated with a higher risk of recurrence and worse survival outcomes were identified: discontinuation of neo-adjuvant chemotherapy cycles, tumor size >18 mm, triple negative breast cancer, and ypN+ disease. Our study highlights the importance of evaluating the patterns of residual disease for better postoperative management of breast cancer patients. Abstract Backgrounds: The majority of breast cancer (BC) patients treated with neo-adjuvant chemotherapy (NAC) achieves a pathologic partial response with different patterns of residual disease. No clear correlation between these patterns and oncological results was described. Our aims were to define the predictive factors for different patterns of residual disease and compare the outcomes between the scattered versus the circumscribed pattern. Methods: We reviewed 219 postoperative surgical specimens. Patients were divided into two groups: scattered versus circumscribed. Disease-free survival (DFS), distant DFS (DDFS), and overall survival (OS) were analyzed. Results: The scattered and circumscribed patterns were assessed in 111 (50.7%) and 108 (49.3%) patients. Two independent predictive factors for the circumscribed pattern were identified: discontinuation of NAC cycles (p = 0.011), and tumor size post-NAC >18 mm (p = 0.022). No difference was observed in terms of DFS and DDFS. Patients with the scattered pattern exhibited a statistically significant better OS. Discontinuation of NAC cycles, tumor size >18 mm, triple-negative BC, and ypN+ were associated with increased recurrence and poorer survival. Conclusions: Discontinuation of NAC cycles and tumor size are independent factors associated with patterns of residual disease. The scattered pattern presents better survival. Understanding the relationship between NAC, the residual pattern, and differences in survival outcomes offers the potential to optimize the therapeutic approaches.
Influence of fish trade activities on the environment in Gikomba fish market, Nairobi County, Kenya

Post-harvest fisheries activities have been cited as contributors to environmental degradation. The current sanitary situation in urban fish markets is worrying and present threats to the public health and the surrounding environment. The research aimed to investigate and understand how the fish trader’s activities influence the environmental situation in fish markets. A descriptive survey design was used for the research. The target for the study was the fish traders of Gikomba fish market, Nairobi. Random sampling of fish traders was done from a register, using Fischer’s formulae, to calculate the number of respondents. Data was collected through a structured questionnaire and was processed using EXCEL and SPSS software packages. Descriptive statistics (frequencies, percentages,) and inferential statistics (Chi square and Logistic Regression) were used to explain the variables. 54% of the respondents did not get piped water. 63.5% of the respondents did not have waste bins and only 31.5% participated in clean-ups. Majority (60.5%) of the respondents noted that fish wastes had a negative effect on the environment. Chi square tests results for fish operator practices in most attributes was statistically associated with environmental situation (P< 0.05). Logistic regression tests results proved that practices such as use of water, disposal of wastes, use of protective clothing and participation in cleanups had a statistically significant influence on the environmental situation (P< 0.05). Perceptions attributes on amount of waste generated, possession of health certificates, drainage infrastructure had a significant influence on the environmental situation (P< 0.05). The researcher noted that 76%, respondents exhibited high level of awareness on the governmental institutional requirements on hygiene and participation in environmental management. Awareness on government institutions services and options available on fish wastes recycling were attributes that significantly affected the environmental situation (P< 0.05). The overall findings led to a support of the key research hypotheses that fish handling practices is significantly related to the environmental situation (P<0.05), perception on environmental management is significantly related to the environmental situation (P<0.05), and awareness on institutional guidelines is significantly related to the environmental situation(P<0.05). The study concluded that fish trade activities affect the environmental situation. Improving on the identified key attributes would result in an improved environmental situation. The research recommended that the Department of Fisheries needs to review the modalities for fish handling throughout the marketing chain. Emphasis should be put on disposal of fish wastes in the major fish markets, fish wastes recycling options, training of fish operators and capacity development of staff.
Papel del receptor de glicina en la expresión en membrana de receptores ionotrópicos de glutamato en cerebelo e hipocampo. Alteraciones en modelos animales de encefalopatía hepática

Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome, which can be present in patients with acute or chronic liver disease. It is characterized by progressive alterations of cognitive functions, motor and sleep as a result of liver failure and it can progress at different stages to coma and death. The mechanisms that lead to neurological disorders in HE are not well established but they begin to be identified in animal models. The most accepted hypothesis about the neurobiological basis of the HE indicate a synergistic combination of two factors: the high concentration of ammonium or hyperammonemia, due to poor elimination of this toxin in the liver and neuroinflammation. These two factors lead to alterations in glutamatergic neurotransmission that are responsible of cognitive and motor impairment. One of the mechanisms that could contribute to altered neurotransmission is a change in membrane receptor expression of glutamate neurotransmitters. Chronic treatment with cGMP restores the ability of learning and memory in animal models of hepatic encephalopathy. Recently, it has been described that extracellular cGMP modulates glycine receptor function. The aim of this study is to analyze whether a glycine receptor antagonist affects membrane expression of ionotropic receptors in cerebellum and hippocampus (NMDA, AMPA) involved in learning and memory processes. Ex vivo brain slices will be used to study membrane expression of these receptors and their involvement in cognitive and motor impairment in animal models of hepatic encephalopathy. In this paper we have seen that inhibition of glycine receptor modulates membrane expression of NMDA and AMPA receptors and can restore the levels of membrane expression of some of its subunits in chronic hyperammonemia. Comparing the results with studies of cGMP, we can say that it could be the mediator of the effects of extracellular cGMP on the membrane expression of NMDA and AMPA receptors in cerebellum and hippocampus.
WATER WAVES AND SIGNIFICANCE OF WAVE HEIGHT IN THE BAY OF BENGAL

Jabed MA, Alam MS (2015) Water waves and significance of wave height in the Bay of Bengal. J. Innov. Dev. Strategy. 9(2), 34-43. This paper presents a method to estimate the water waves and significant wave height from the observed data. For the estimation of extreme water waves and significant wave height, a precise representation of the data by a certain probability function is highly desirable. Since we do not have any specific technique to meet this requirement, this situation seriously affects the reliability of the current method. It expresses asymptotically the cumulative distribution of the water waves and significant wave height as a combination of an exponential and power of the water waves and significant wave height. The parameters involved are determined numerically by a nonlinear minimization procedure. The results of the analysis show that the data are well represented by the proposed method over the entire range of the cumulative distribution.