Miracle-dz/UniFAR-FTUs huggingface dataset:
High-Mobility Group Box 1 (HMGB1) Protein in Parkinson's Disease Research: A 10-Year Bibliometric Analysis.

BACKGROUND Parkinson's disease (PD), the most prevalent motoric neurodegenerative disease, has been intensively studied to better comprehend its complicated pathogenesis. Chronic neuroinflammation is a major factor contributing to the development of PD. Reportedly, high-mobility group box 1 (HMGB1) protein is capable of mediating neuroinflammatory response. In this regard, knowledge mapping of the research linking HMGB1 to PD is necessary. OBJECTIVE Herein, we perform a dynamic and longitudinal bibliometric analysis to explore the hotspots and current trends of HMGB1-related PD publications during the past decade. METHODS All PD publications focusing on HMGB1 protein were retrieved from the PubMed database using the search terms "Parkinson's disease" and "hmgb1". Using filters, only English articles published between 2011 and 2022 were selected. The Bibliometrix and Biblioshiny packages from R software were used to conduct the bibliometric analysis. RESULTS The filtered search identified 47 articles (34 original articles and 13 review articles), published between 2011 and 2022. There was an increase trend in the number of articles published, with an annual growth rate of 19.35 percent. In terms of research and scientific collaboration in this field, the United States is in the lead, followed by China, Malaysia, and Australia. Compared to other countries, the United States and China had the highest level of collaboration in this research area. Neuroinflammation, microglia, and receptor for advanced glycation end-products (RAGE) represent the top three frontiers and hotspots for HMGB1-related PD research. According to the thematic evolution analysis, over the last decade, PD, HMGB1 and microglia were addressed individually, however, since 2017, these topics were frequently discussed within the same cluster: neuroinflammation. Furthermore, PD, HMGB1, and neuroinflammation domains co-occurred in majority of the research discussion. CONCLUSIONS The link between HMGB1 and PD was realized a decade ago and becomes increasingly important over time. Our findings can aid scholars in comprehending the global context of HMGB1/PD relationship and provide significant insights for future PD research.
On Path Consistency for Binary Constraint Satisfaction Problems

Constraint satisfaction problems (CSPs) provide a flexible and powerful framework for modeling and solving many decision problems of practical importance. Consistency properties and the algorithms for enforcing them on a problem instance are at the heart of Constraint Processing and best distinguish this area from other areas concerned with the same combinatorial problems. In this thesis, we study path consistency (PC) and investigate several algorithms for enforcing it on binary finite CSPs. We also study algorithms for enforcing consistency properties that are related to PC but are stronger or weaker than PC. We identify and correct errors in the literature and settle an open question. We propose two improvements that we apply to the well-known algorithms PC-8 and PC-2001, yielding PC-8 + and PC-2001 +. Further, we propose a new algorithm for enforcing partial path consistency, σ-∆-PPC, which generalizes features of the well-known algorithms DPC and PPC. We evaluate over fifteen different algorithms on both benchmark and randomly generated binary problems to empirically demonstrate the effectiveness of our approach. iii ACKNOWLEDGMENTS I would like to thank my adviser, Professor Choueiry, without whom this work would not have been possible. She went above and beyond to make herself available to complete this work. Her insight and advise have been essential, and I very much appreciate her efforts. I would also like to thank Robert Woodward who created much of the infrastructure needed to run the empirical evaluations. His help troubleshooting problems as they arose was invaluable. Thanks are also due to the members of my examination committee, Professor Wei and Professor Revesz. Also, Tony Schneider, who has already taken the first step towards implementing these ideas in search. Finally, I would like to thank my parents for their support.
A case study of the financial performance of selected four wheeler automobile companies in India

The Indian automobile industry has performed incredible in present time. In today’s time, Indian automobile industry provides varieties of cars and provides all models which available on the world wide. When we are talking about the Indian automobile industry, which includes Maruti Suzuki, Tata motors, Mahindra and Mahindra, Hyundai motors, Hero Honda and Hindustan motors to a number of companies. In the early time, Indian automobile industry depends on foreign technology for their growth, then after, Indian producers have started to produce their own equipment’s in India. On a globe, the Indian automobile sector has 7th rank. Automobile industry experts forecast that in future, it will be a huge rise in this sector. As an exporter of automobiles in India became a fourth position after Japan, South Korea and Thailand. As per the thinking of experts in 2050 on Indian roads about 611 million cars which will be the highest in all over the world.
Radiotherapy in Uveal Melanoma: A Review of Ocular Complications

Uveal melanoma represents the most prevalent form of primary malignant intraocular tumor in adults. Historically, enucleation was considered the gold-standard approach in the treatment of uveal melanoma. Currently, radiotherapy is the most commonly used therapy, aiming at a better quality of life. However, radiotherapy can result in several ocular complications, some of which may be vision-threatening. Radiation-induced dry eye, scleral necrosis, cataract, rubeosis iridis, neovascular glaucoma, radiation retinopathy, maculopathy, and optic neuropathy are the most common complications. This article aims to summarize the current literature regarding the ocular complications after radiotherapy, as well as their clinical features, risk factors, and management strategies. A thorough understanding of these issues is crucial for ophthalmologists and oncologists to provide optimal patient care, improve visual outcomes, and minimize long-term complications.
Fieldwork Monitoring for the European Social Survey: An illustration with Belgium and the Czech Republic in Round 7

Abstract Adaptive and responsive survey designs rely on monitoring indicators based on paradata. This process can better inform fieldwork management if the indicators are paired with a benchmark, which relies on empirical information collected in the first phase of the fieldwork or, for repeated or longitudinal surveys, in previous rounds or waves. We propose the “fieldwork power” (fieldwork production per time unit) as an indicator for monitoring, and we simulate this for the European Social Survey (ESS) Round 7 in Belgium and in the Czech Republic. We operationalize the fieldwork power as the weekly number of completed interviews and of contacts, the ratio of the number of completed interviews to the number of contact attempts and to the number of refusals. We use a repeated measurement multilevel model, with surveys in the previous rounds of the European Social Survey as the macro level and the weekly fieldwork power as repeated measurements to create benchmarks. We also monitor effort and data quality metrics. The results show how problems in the fieldwork evolution can be detected by monitoring the fieldwork power and by comparing it with the benchmarks. The analysis also proves helpful regarding post-survey fieldwork evaluation, and links effort, productivity, and data quality.
Tackling the misconceptions and prejudices surrounding citizen journalism

The study focus on ways of tackling the misconception and prejudices surrounding citizen journalism. citizen journalism is a process of collecting, processing, analyzing and dissemination of news or information by untrained journalist using the social media platforms. This study aims to examine the various misconceptions and prejudices that give rise to ethical concerns about citizen journalism practice in Nigeria, to find out the legal concerns about citizen journalism practice in Nigeria and to find out ways of tackling misconceptions and prejudices surrounding citizen journalism practice in Nigeria. The study is anchored on theory of public sphere and technological determinism theory. The study adopted survey method of research with an in-depth interview as instrument for data collection. Interview was conducted with four journalists, three working in the mainstream news organizations in Nigerian. The results of the study indicated lack of legal provision that will guide the practice of citizen journalism, sentimental attachment to issues by citizen journalist, lack of censorship are the reasons for the misconceptions and prejudices surrounding citizen journalism. It was recommended that legal provision and censorship to guide the practice of citizen journalism, stated punishment for defaulters, use of artificial intelligence to control information or news publish by citizen journalists, training of citizen journalists among others will help to tackle the misconceptions and prejudices surrounding citizen journalism.
Bisphenol-A Induced Changes in Blood Indices of Channa punctatus and Alleviation with Vitamin C

Bisphenol A, a suspected endocrine disrupting chemical, is widely used in the manufacture of polycarbonate plastics and epoxy resins. With increasing industrialisation, the release of Bisphenol A in the environment is increasing in India. Bisphenol A is released in the environment from landfill leachates, industrial point sources, municipal sewage and by burning. Water bodies are the ultimate sink for Bisphenol A. People consuming fish captured from water bodies polluted with Bisphenol A can be exposed to the chemical through the fish. Channa punctatus, is an important food fish of India and neighbouring areas. In this study the effect of 30 days Bisphenol A exposure on the haematological parameters of Channa punctatus was assessed. Vitamin C, a known antioxidant, was shown to improve the changes in almost all haematological indices tested except at the highest concentrations of Bisphenol A used in this study. This study shows that Channa punctatus can be used as a useful sentinel species to assess pollution of water bodies by Bisphenol A and that the deleterious effects of Bisphenol A are probably caused by increasing oxidative stress in tissues which can be offset by vitamin C.
Artificial Intelligence in the Advanced Diagnosis of Bladder Cancer-Comprehensive Literature Review and Future Advancement

Artificial intelligence is highly regarded as the most promising future technology that will have a great impact on healthcare across all specialties. Its subsets, machine learning, deep learning, and artificial neural networks, are able to automatically learn from massive amounts of data and can improve the prediction algorithms to enhance their performance. This area is still under development, but the latest evidence shows great potential in the diagnosis, prognosis, and treatment of urological diseases, including bladder cancer, which are currently using old prediction tools and historical nomograms. This review focuses on highly significant and comprehensive literature evidence of artificial intelligence in the management of bladder cancer and investigates the near introduction in clinical practice.
Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback

The aryl hydrocarbon receptor (AHR) exerts major roles in xenobiotic metabolism, and in immune and barrier tissue homeostasis. How AHR activity is regulated by the availability of endogenous ligands is poorly understood. Potent AHR ligands have been shown to exhibit a negative feedback loop through induction of CYP1A1, leading to metabolism of the ligand. Our recent study identified and quantified 6 tryptophan metabolites (eg, indole-3-propionic acid, and indole-3-acetic acid) in mouse and human serum, generated by the host and gut microbiome, that are present in sufficient concentrations to individually activate the AHR. Here, these metabolites are not significantly metabolized by CYP1A1/1B1 in an in vitro metabolism assay. In contrast, CYP1A1/1B metabolizes the potent endogenous AHR ligand 6-formylindolo[3,2b]carbazole. Furthermore, molecular modeling of these 6 AHR activating tryptophan metabolites within the active site of CYP1A1/1B1 reveal metabolically unfavorable docking profiles with regard to orientation with the catalytic heme center. In contrast, docking studies confirmed that 6-formylindolo[3,2b]carbazole would be a potent substrate. The lack of CYP1A1 expression in mice fails to influence serum levels of the tryptophan metabolites examined. In addition, marked induction of CYP1A1 by PCB126 exposure in mice failed to alter the serum concentrations of these tryptophan metabolites. These results suggest that certain circulating tryptophan metabolites are not susceptible to an AHR negative feedback loop and are likely important factors that mediate constitutive but low level systemic human AHR activity.
Case Report: Multiple atherosclerotic plaques at its extreme in synchrony

Peripheral artery (PAD) disease in association with renal artery stenosis is an important association which predicts the severity of the disease. An increase in the number of vessels affected by peripheral artery disease increases the chances of renal artery stenosis. In our case, the patient had primarily presented with anginal chest pain with complaints of claudication which on further investigation was diagnosed to be a triple vessel coronary artery disease along with bilateral subclavian and bilateral renal stenosis. On detailed history taking, risk factors like hypertension and chronic smoking was found to be present in our case which predisposed to peripheral artery disease secondary to atherosclerosis which was diagnosed on further investigations. Although the association of renal artery stenosis is not very rare in cases of severe peripheral vascular diseases, the presence of a triple vessel coronary artery disease in synchrony is what makes it unique. Take away lesson from this case report is importance of early diagnosis of dyslipidemia causing atherosclerosis and its complications. Multiple atherosclerotic lesions in synchrony i.e, bilateral renal artery stenosis with bilateral subclavian artery stenosis with coronary artery triple vessel atherosclerotic disease like in our case and its severity should create awareness among health care individuals and early treatment measures including lifestyle modifications should be considered to avoid such drastic events.
The Representation of Spacetime in the Medial Entorhinal Cortex Derives from an Underlying Model of Computation over the Complex Field

The cortex forms a model of computation over the complex field. Mutually inhibitory logical primitives normalize amplitudes under the 2-norm. A sufficient class of linear unitary operators exists to support a universal model of computation. Recent results show that the medial entorhinal cortex constructs a representation of spacetime from this underlying model. The lattice-like computational history is automatically generally covariant and background independent under transformations providing for derivation of an Einstein-Regge spacetime.
Geometry of X‐ray based measurement of residual strain at desired penetration depth

X‐ray based measurement of residual lattice strains at chosen penetration depth is one of the methods for investigating strain inhomogeneities in near‐surface layers of polycrystalline materials. The measurement relies on determining shifts of Bragg peaks for various directions of the scattering vector with respect to the specimen. At each of these directions, to reach a given the penetration depth, a proper specimen orientation is required. The task of determining such orientations, albeit elementary, is quite intricate. The existing literature describes only partial solutions with unspecified domains of application, which fail if applied to beyond the domains. Therefore, geometric aspects of the measurement are analyzed in details. Explicit bounds on measurement parameters are given. The equation fundamental for the procedure is solved with respect to specimen orientations. For a given direction of the scattering vector, there are generally four different specimen orientations leading to the same penetration depth. This simple fact (overlooked in previous analyses) can be used for improving reliability of measurement results. Analytical formulas for goniometer angles representing these orientations are provided.
Doping, co-doping, and defect effects on the plasmonic activity of ZnO-based transparent conductive oxides

Using simulations from first principles we investigate the microscopic role of doping on the optoelectronic properties of X-doped ZnO (XZO, X=Al, F), as transparent conductive oxide for energy applications. We show how the interplay between (co)dopants and defects affects TCO characteristics of the samples. Finally, we study the plasmonic activity of XZO in the near-IR/visible range and in particular at wavelength relevant for telecommunications (1.5 μm), confirming recent experimental results.
Asymmetrical Sequential Load Modulated Balanced Amplifier With Composited Impedance Inverter and Reciprocal Mode for Broadband Applications

In this brief, the design of a broadband asymmetrical sequential load modulation balanced amplifier (ASLMBA) is presented. The composited impedance inverters, which contain the intrinsic elements and the output matching networks (OMNs) of the balanced power amplifier (BPA) transistors, are inserted before the output coupler of the BPA pair. In this way, optimal matching condition of the BPA transistors can be maintained over a wide bandwidth. In addition, to ensure an optimal load modulation trajectory of the control amplifier (CA) without over-saturation, a reciprocal mode is applied to the BPA pair by elaborately changing the turn-on sequence of the sub-amplifiers, which is affected by the composited impedance inverter and the OMN of the control amplifier. It is illustrated that the proposed ASLMBA can effectively maintain high efficiency over an extended dynamic range and a wide bandwidth. As a proof of concept, a broadband ASLMBA working over 1.35-2.55 GHz is designed and measured in this brief. Experimental results show that the designed ASLMBA achieves a saturation output power of 43.2-45.1 dBm with a saturation gain of 6.5-10.5 dB and a saturation drain efficiency (DE) of 57.8-77.7%. Meanwhile, the 6 dB and 10 dB back-off DEs of the designed ASLMBA are 51.3-66.6% and 47.7-68.9%, respectively.
Novel end‐fire dipole array antenna with gain and bandwidth enhancement

A gain and bandwidth enhanced end‐fire dipole array antenna is presented. In order to improve the bandwidth of the original dipole array antenna, 2 parasitic metallic strips are closely placed at the end‐fire direction. Three pairs of I‐shaped resonators with different lengths are placed on the broadsides of the antenna to increase the gain. The measured results show that the antenna has bandwidth of 80.3% for voltage standing wave ratio <2 and a gain of 4.72‐7.3 dBi. When compared with the original design, the presented antenna has a 9.8% wider bandwidth and a gain improvement of 4.62 dB. The gain flatness and the frequency selectivity are also improved. The presented antenna is more favorable in wireless and radar applications compared with the original design.
Design of high throughput recursive and non-recursive digital filters in one and two dimensions with Canonic Signed Digit coefficients and sub-expression elimination using Genetic Algorithm.

In this dissertation methods of obtaining high throughput rate digital filters are examined. The use of Canonic Signed Digit (CSD) filter coefficients is established and a new chromosome coding technique is developed to enable efficient design of non-recursive filters using a Genetic Algorithm. The new genetic algorithm approach using the proposed new coding scheme is extended to efficiently handle recursive filters using a new unstable penalty factor to handle the instability constraints imposed by such filters. A technique is presented that allows these new methods to be applied to the design of high throughput 2-D filters. The throughput rate of CSD coefficients digital filters is further increased by the use of common sub-expression elimination. A new graphical transformation is presented that allows for optimization of the elimination of CSD-coefficient common sub-expressions in both the vertical and horizontal dimensions. The effectiveness of the proposed methods is demonstrated with example designs and comparisons to other methods.
The Role of Convective Self‐Aggregation in Extreme Instantaneous Versus Daily Precipitation

The impacts of convective self‐aggregation on extreme precipitation and updraft velocity are investigated by using the Weather Research and Forecasting Model in the idealized setting of radiative‐convective equilibrium with a 3‐km horizontal resolution. Aggregated and unaggregated states are achieved by conducting simulations with fully interactive and fixed radiation, respectively. We find that convective self‐aggregation has a negligible impact on extreme instantaneous precipitation but weakens the extreme updrafts and condensation, indicating a negative dynamical contribution from aggregation to extreme instantaneous precipitation. However, this is balanced by higher precipitation efficiency to maintain the same extreme instantaneous precipitation. This balance occurs because updrafts decrease mainly above the freezing level, suppressing graupel production. As graupel has a longer residence time than rain, less graupel formation with aggregation implies enhanced instantaneous local precipitation efficiency. Peak updraft velocity scales with the vertical integral of buoyancy, measured with respect to the local prestorm environment. This local environment is warmer and moister at middle and high levels when convection is aggregated compared to when it is unaggregated, reducing the buoyancy and updraft velocity. Unlike extreme instantaneous precipitation, extreme daily precipitation is stronger in aggregated states, as self‐aggregation localizes and sustains updrafts and condensation in relatively fixed locations. Our results imply that extreme instantaneous precipitation is more sensitive to microphysical processes while extreme daily precipitation is more linked to the degree of aggregation.