Miracle-dz/UniFAR-FTUs huggingface dataset:
Digitization and Blockchain in Finance, The Netherlands in 2020 and 2021

The exploratory research in 2020 received a lot of attention in trade journals in the Netherlands and in the international context of academic journals, webinars and conferences. This led to this research in 2021, including a reorientation on the structure of the research. Due to the further development of the faculty in 2020 and 2021, the questions from the research were further professionalized, peer reviewed by experts and supplemented. In addition, it is interesting and scientifically important to place the research more in both a national and international perspective, both with regard to professional groups and with regard to other studies, such as that of Controllers Magazine, After various inventorying discussions at the end of 2020, whether or not at the request of the stakeholders, this led to a reorientation on the conducting of the research. At the beginning of 2021, the study was therefore extended almost simultaneously to: (a) all members of the Working field commission (Werkveldcommissie; WVC) of the Accountancy (AC), Finance, Tax and Advice (FTA, formerly Fiscal Law and Economics) and Finance & Control (FC) programmes of the Academy of Finance, Economics and Management (FEM) at Saxion University of Applied Sciences, (b) all members of the foundation of collaborating chartered accountants and accounting and bookkeeping firms (SRA), a network organization of 375 independent audit firms with 900 branches in the Netherlands, and (c) international sister universities of Saxion University of Applied Sciences.
An H5-Bridge-Based Laddered $CLLC$ DCX With Variable DC Link for PEV Charging Applications

Plug-in electric vehicles’ charger is preferred to cover an ultrawide battery voltage range with the vehicle-to-grid capability. Conventional bidirectional resonant dc–dc converters suffer from the contradiction among wide voltage gain range, squeezed dc-link voltage span, and narrow switching frequency band. To solve the issue, this article proposes a novel H5-bridge-based bidirectional $CLLC$ converter. By configuring the switch pattern, the H5-bridge can form the modes of single half-bridge, dual half-bridge, half full-bridge, and dual full-bridge, respectively. Correspondingly, six gain curves can be derived. Combined with the variable dc-link framework, the converter constrains the switching frequency in the vicinity of the resonant frequency with optimal efficiency. The converter achieves an ultrawide battery voltage range with a squeezed dc-link span. A bidirectionally synchronous rectification method is proposed to improve the efficiency further. To verify the proposed concept, a 1-kW rated prototype with a 320–420 V dc link is built and tested. It validates the battery voltage 55–420 V for charging and 230–420 V for discharging. Zero-voltage turn-on and zero-current turn-off are achieved in the rectifying mosfets. The prototype exhibits 98.04% peak efficiency and good overall efficiency performance.
First DNA Sequencing in Beninese Indigenous Cattle Breeds Captures New Milk Protein Variants

This study investigated polymorphisms in the milk protein genes CSN1S1, CSN2, CSN1S2, CSN3, LALBA, and LGB, and casein haplotypes in Beninese indigenous cattle. Considering 67 animals, DNA sequencing of the genes’ exons, flanking regions and parts of the 5′-upstream regions identified 1058 genetic variants including 731 previously unknown. In addition, four novel milk protein variants were detected, including CSN3K (p.Ala66Val), LALBAF (p.Arg58Trp), LGBB1 (p.Ala134Val) and LGBK (p.Thr92Asnfs*13). CSN3K is caused by a novel SNP (BTA6:85656526C>T, exon 4) whereas LALBAF and LGBB1 are due to rs714688595C>T (exon 1) and rs109625649C>T (exon 4), respectively. Regarding LGBK, a frameshift insertion of one adenine residue at BTA11:103257980 (exon 3) induces a premature translation termination resulting in a 46% reduction of the reference protein sequence. The casein polymorphisms formed five main CSN1S1-CSN2-CSN1S2-CSN3 haplotypes including B-A1-A-B, B-A1-A-A and C-A2-A-B which are predominant in the investigated cattle breeds. Moreover, in silico analyses of polymorphisms within the 5′- and 3′- untranslated regions of all six milk proteins revealed effects on microRNA and transcription factor binding sites. This study suggests a large genetic variation of milk protein genes in Beninese cattle, which should be investigated in further studies for their effects on milk production, including quality and yield traits.
Diversity of Potentially Pathogenic Escherichia coli O104 and O9 Serogroups Isolated before 2011 from Fecal Samples from Children from Different Geographic Regions

In 2011, an outbreak of hemorrhagic colitis and hemolytic uremic syndrome (HUS) was reported in Europe that was related to a hybrid STEAEC of Escherichia coli (E. coli) O104:H4 strain. The current study aimed to analyze strains of E. coli O104 and O9 isolated before 2011. The study included 47 strains isolated from children with and without diarrhea between 1986 and 2009 from different geographic regions, as well as seven reference strains. Serotyping was carried out on 188 anti-O and 53 anti-H sera. PCR was used to identify DEC genes and phylogenetic groups. Resistance profiles to antimicrobials were determined by diffusion in agar, while PFGE was used to analyze genomic similarity. Five serotypes of E. coli O104 and nine of O9 were identified, as well as an antigenic cross-reaction with one anti-E. coli O9 serum. E. coli O104 and O9 presented diarrheagenic E. coli (DEC) genes in different combinations and were located in commensal phylogenetic groups with different antimicrobial resistance. PFGE showed that O104:H4 and O9:(H4, NM) strains from SSI, Bangladesh and México belong to a diverse group located in the same subgroup. E. coli O104 and O9 were classified as commensal strains containing DEC genes. The groups were genetically diverse with pathogenic potential making continued epidemiologic surveillance important.
Weissella cibaria MG5285 and Lactobacillus reuteri MG5149 attenuated fat accumulation in adipose and hepatic steatosis in high-fat diet-induced C57BL/6J obese mice

Background Excessive consumption of dietary fat is closely related to obesity, diabetes, insulin resistance, cardiovascular disease, hypertension, and non-alcoholic fatty liver disease. Recently, probiotics have been highly proposed as biotherapeutic to treat and prevent diseases. Previously, there are studies that demonstrated the beneficial effects of probiotics against metabolic disorders, including obesity and diabetes. Objective We investigated the anti-obesity effect and mechanism of action of four human-derived lactic acid bacterial (LAB) strains (Lacticaseibacillus rhamnosus MG4502, Lactobacillus gasseri MG4524, Limosilactobacillus reuteri MG5149, and Weissella cibaria MG5285) in high-fat diet (HFD)-induced obese mice. Design Obesity was induced in mice over 8 weeks, with a 60% HFD. The four human-derived LAB strains (2 × 108 CFU/mouse) were orally administered to male C57BL/6J mice once daily for 8 weeks. Body weight, liver and adipose tissue (AT) weights, glucose tolerance, and serum biochemistry profiles were determined. After collecting the tissues, histopathological and Western blot analyses were conducted. Results Administration of these LAB strains resulted in decreased body weight, liver and AT weights, and glucose tolerance. Serum biochemistry profiles, including triglyceride (TG), total cholesterol, low-density lipoprotein cholesterol, and leptin, pro-inflammatory cytokines, improved. Hepatic steatosis and TG levels in liver tissue were significantly reduced. In addition, the size of adipocytes in epididymal tissue was significantly reduced. In epididymal tissues, Limosilactobacillus reuteri MG5149 and Weissella cibaria MG5285 groups showed a significantly reduced expression of lipogenic proteins, including peroxisome proliferator-activated receptor γ, CCAAT/enhancer-binding protein α, fatty acid synthase (FAS), and adipocyte-protein 2. In addition, sterol regulatory element-binding protein 1-c and its downstream protein FAS in the liver tissue were significantly decreased. These strains attenuated fat accumulation in the liver and AT by upregulating the phosphorylation of AMP-activated protein kinase and acetyl-CoA carboxylase in HFD-fed mice. Conclusion We suggest that L. reuteri MG5149 and W. cibaria MG5285 could be used as potential probiotic candidates to prevent obesity.
Mental Illness Knowledge, Stigma, Help-Seeking Behaviors, Spirituality and the African American Church

Purpose.This study examined the relationship among mental illness knowledge, stigma, help-seek-ing behaviors, and spirituality among African Americans who regularly attend church. It further assessesif demographic variables differ between African Americans who think their church should play a role inaddressing mental illness awareness and those who are not. Methods. A convenience sample of 409 AfricanAmerican church-going adults responded to an anonymous survey. Results. Knowledge about mental ill-ness was positively correlated with help-seeking behaviors (r=.227) and negatively correlated with stigma(r=-.272). Help-seeking behaviors were negatively correlated with stigma (r=-440). Conclusions. There isa need to increase knowledge about mental health signs and symptoms recognition and to decrease stigmaamong this community as these help support mental help-seeking behaviors. Respondents were supportiveof their church increasing knowledge and awareness, as well as providing mental health services.
The Relationship Between the Distal Tibial Fibular Syndesmosis and the Varus Deformity in Patients With Varus Ankle Osteoarthritis

Background: The impact of varus ankle osteoarthritis (OA) on the distal tibial fibular syndesmosis is poorly described. This study aimed to investigate the possible relationship between the condition of the distal tibial fibular syndesmosis and the degree of the varus deformity using weightbearing simulated computed tomography (CT), in patients with varus ankle OA. Methods: This retrospective comparative study included 155 varus ankles, divided into 4 Takakura-Tanaka groups (stage 2, 3a, 3b, and 4). A control group comprised 35 ankles without prior ankle disorders. The angles between the tibial shaft and the articular surface of the tibial plafond on the anteroposterior view (TAS), and articular surfaces of the tibial plafond and talar dome (TTW) were measured from weightbearing ankle radiographs. The varus angle of the ankle (VA) was defined as 90 – TAS + TTW. On the CT axial view, 1 cm proximal to the tibial plafond, the area of the syndesmosis (“CT-area”) and the distance between the fibula and the tibia (CT-FCS) were measured. Results: The CT area in stages 2, 3a, 3b, 4, and control group were 99, 79, 77, 103, and 97 mm2, respectively. The CT-FCS were 3.5, 3.1, 2.9, 4.3, and 3.9 mm, respectively. In all 155 OA ankles, CT area and CT-FCS were negatively correlated with the VA (correlation coefficient r = –0.38, P < .01; and r = 0.38, P < .01, respectively). Both CT area and CT-FCS were significantly smaller in stages 3a and 3b than in the control group (P < .01). Conclusion: There may be a relationship between the narrowing of the syndesmosis and the varus deformity in patients with varus ankle OA, especially in stages 3a and 3b. Clinical Relevance: Clinicians should be aware of the impact of varus ankle arthritis on the distal tibial fibular syndesmosis when operatively treating varus ankle OA. For some patients, the isolated treatment for the tibiotalar joint may be insufficient, and treatment for the syndesmosis as well as tibiotalar joint may be needed. Level of Evidence: Level III, retrospective case control study.
Protecting the Limited Liability Feature of Your Family Business: Evidence from the U.S. Court System

One of the benefits cited for the organizational structure of a corporation or limited liability company is the limited liability feature associated with these forms of organization. However, our legal system contains a judicial doctrine known as piercing the corporate veil, which essentially asks the courts to disregard the limited liability feature of the organization and impose personal liability on the shareholders, officers, andqor directors. This study provides evidence regarding the extent to which the U.S. courts have ruled to pierce the corporate veil and suggests steps that family-owned businesses can take to minimize this potential risk.
CBFB Break-Apart FISH Testing: An Analysis of 1629 AML Cases with a Focus on Atypical Findings and Their Implications in Clinical Diagnosis and Management

Simple Summary The inv(16)/t(16;16) AML is a disease that is considered relatively easy and straightforward to be diagnosed in the clinical laboratories. Up to date, CBFB FISH and/or CBFB-MYH11 RT-PCR are still the major diagnostic assays utilized in the clinical laboratories. However, incidental CBFB FISH findings and their implication in clinical laboratory diagnostics and management, especially in the era of next-generation sequencing (NGS)-based methods, have not been systemically investigated. In this study, we systemically studied over 1600 AML cases tested with CBFB FISH. Over 5% of cases with a confirmed CBFB rearrangement were challenging, including those with discrepant FISH and RT-PCR results and/or atypical FISH findings. Meanwhile, atypical FISH findings usually indicate additional chromosome 16 aberrations (AC16As) overlooked by other methods including RT-PCR and almost all NGS-based methods if following the published parameters. The information revealed in this study will be useful for further workup and interpreting atypical CBFB FISH findings and confirmation of inv(16)/t(16;16) AML diagnosis and related treatment, as well as selection of samples to better validate NGS-based new diagnostic methods. Abstract Fluorescence in situ hybridization (FISH) is a confirmatory test to establish a diagnosis of inv(16)/t(16;16) AML. However, incidental findings and their clinical diagnostic implication have not been systemically studied. We studied 1629 CBFB FISH cases performed in our institution, 262 (16.1%), 1234 (75.7%), and 133 (8.2%) were reported as positive, normal, and abnormal, respectively. The last included CBFB copy number changes (n = 120) and atypical findings such as 3′CBFB deletion (n = 11), 5′CBFB deletion (n = 1), and 5′CBFB gain (n = 1). Correlating with CBFB-MYH11 RT-PCR results, totally 271 CBFB rearrangement cases were identified, including five with discrepancies between FISH and RT-PCR due to new partner genes (n = 3), insertion (n = 1), or rare CBFB-MYH11 variant (n = 1) and eight with 3′CBFB deletion. All cases with atypical findings and/or discrepancies presented clinical diagnostic challenges. Correlating FISH signal patterns and karyotypes, additional chromosome 16 aberrations (AC16As) show impacts on the re-definition of a complex karyotype and prognostic prediction. The CBFB rearrangement but not all AC16As will be detected by NGS-based methods. Therefore, FISH testing is currently still needed to provide a quick and straightforward confirmatory inv(16)/t(16;16) AML diagnosis and additional information related to clinical management.
Pre-Clinical Models in Implant Dentistry: Past, Present, Future

Biomedical research seeks to generate experimental results for translation to clinical settings. In order to improve the transition from bench to bedside, researchers must draw justifiable conclusions based on data from an appropriate model. Animal testing, as a prerequisite to human clinical exposure, is performed in a range of species, from laboratory mice to larger animals (such as dogs or non-human primates). Minipigs appear to be the animal of choice for studying bone surgery around intraoral dental implants. Dog models, well-known in the field of dental implant research, tend now to be used for studies conducted under compromised oral conditions (biofilm). Regarding small animal models, research studies mostly use rodents, with interest in rabbit models declining. Mouse models remain a reference for genetic studies. On the other hand, over the last decade, scientific advances and government guidelines have led to the replacement, reduction, and refinement of the use of all animal models in dental implant research. In new development strategies, some in vivo experiments are being progressively replaced by in vitro or biomaterial approaches. In this review, we summarize the key information on the animal models currently available for dental implant research and highlight (i) the pros and cons of each type, (ii) new levels of decisional procedures regarding study objectives, and (iii) the outlook for animal research, discussing possible non-animal options.
Profils tarifaires dans le monde 2021

Les droits de douane sont-ils devenus un problème du passé grâce aux progrès de la libéralisation multilatérale ou préférentielle des échanges ? De nombreux analystes reportent à présent leur attention sur les mesures non tarifaires (MNT) ou la facilitation des échanges, car les droits de douane nominaux semblent trop faibles pour faire une différence, 5 % étant parfois présenté comme la limite au-dessous de laquelle une différence de droits nominaux n’a plus d’importance. De nos jours, la plupart des échanges Nord-Nord sont assujettis à des droits inférieurs à 5 %, tandis que 80 % des exportations des pays en développement vers les marchés développés se font en franchise de droits. Avec des échanges Sud-Sud dominés par des produits de base passibles de droits faibles, les droits de douane semblent plus un ajout aux coûts totaux du commerce qu’un obstacle au commerce, sauf pour certaines gammes de produits qui restent assujetties à des crêtes tarifaires.1
Stake: a coupled simulation environment for RISC-V memory experiments

The recent emergence of open hardware platforms has drastically reduced the cost required to develop special purpose device architectures. The RISC-V instruction set and associated ecosystem is one such architecture that has become widely popular as the basis for the next generation embedded control systems and IoT devices. Despite the recent popularity of the RISC-V architecture, there is currently very little support for performing architectural experiments of high performance RISC-V devices designed to target high performance computing and high performance analytics applications. Further, there are no general purpose simulation infrastructures that support developing architectural experiments using RISC-V cores coupled to emerging memory devices such as HBM and HMC. As a result, there is currently a significant gap for those seeking to develop high performance architectural models using emerging memory devices and the RISC-V instruction set. The Stake infrastructure is designed to provide integrated simulation capabilities that supports experimentation using RISC-V processing cores as well as emerging memory devices. Stake is constructed using a fusion of the existing RISC-V Spike functional simulation infrastructure coupled to a custom memory generation component within the Sandia Structural Simulation (SST) framework. The result being an integrated simulation infrastructure that has the ability to simulate heterogeneous mixtures of hierarchical caches, traditional DRAM memories and emerging memory devices. We demonstrate this infrastructure with a design study to elicit the efficacy of 64 bit RISC-V cores on executing graph applications using different mixtures of cache, DRAM memories and HMC memories. In this study, we utilize the Graph Analytics Benchmark Suite to drive simulated memory traffic into mixtures of single level and multi-level caches coupled to each of the aforementioned backend memory devices. From this, we determine that in our simulated architecture, the HMC memory configuration with a single (L1) caching layer provides the most advantageous system configuration for executing graph algorithms and applications.
Agenda Setting by News and by the Audience in a News Portal Panel Experiment

ABSTRACT News can powerfully influence audience issue priorities, but the classic experiments on agenda setting occurred decades ago, prior to major changes in media. This calls not only for updated replication, but also for implementing advancements already made in recent non-experimental agenda-setting scholarship. Particularly, the new wave of agenda-setting experimentation should question the original assumptions that news is unique in its agenda-setting power, that issues are independent, and that effects are uniform across party lines. A 12-day experiment embedded in a purpose-built online news portal tested effects of the news agenda and the “user agenda. ” Participants were randomly assigned to encounter more or fewer real, timely stories about three topics (the news agenda) and altered rankings of stories about two other topics in a trending or recommended sidebar (the user agenda). Both agendas had significant effects regardless of partisanship. Contrary to the issue independence assumption but consistent with group threat theory, a user agenda emphasizing anti-Black racism increased immigration importance, particularly among Republicans.
Discriminative optimization algorithm with global–local feature for LIDAR point cloud registration

ABSTRACT The discriminative optimization (DO) algorithm has been successful in three-dimensional LIDAR rigid point cloud registration. However, its feature descriptor is local, which may restrict the robustness of the DO. In this study, for the sake of improving the DO’s robustness, we design a global-local feature descriptor, then we weight the global-local descriptor using the prior information from model point cloud. We compare the proposed approach with eight classical point cloud registration methods using the Stanford Bunny, Oxford SensatUrban and Sydney 3D cross source datasets. Experimental results demonstrate that our proposed approach obtains higher registration accuracy and lower registration root-mean-square-error. In addition, our method is competitive in runtime.
ERBB3 as a therapeutic target in glioblastoma: overexpression can make the difference

ABSTRACT By exploiting an integrated experimental platform based on patient-derived cancer stem cells, we identified a glioblastoma subset characterized by inheritable Erb-B2 Receptor Tyrosine Kinase 3 (ERBB3) overexpression, metabolic dependency on ERBB3 signaling, and liability to ERBB3 targeting. We provide insights on why some glioblastomas may rely on ERBB3 and how to recognize them.
Digital Transformation and Convergence toward the 2030 Agenda’s Sustainability Development Goals: Evidence from Italian Listed Firms

The United Nations 2030 Agenda has emphasized the potential of digital technology to enhance sustainability performance, assuming that digital transformation can enable firms’ convergence toward the Sustainable Development Goals. Despite this, the literature is unclear regarding whether there is a positive relationship between digitalization and sustainability, as the effects of digital transformation are controversial. The main goal of this study was to assess the hypothesis that digital technology contributes to the achievement of Sustainable Development Goals within the UN 2030 Agenda. To test this hypothesis, a textual analysis was performed to assess Italian firms’ digitalization efforts; the obtained results were then related to the selected firms’ ESG scores using a regression analysis. The analysis focused on Italian FTSE MIB listed firms for the period 2016–2019. The findings show a positive relation between digitalization and Sustainable Development Goals, highlighting the relevance of digital technology in implementing the sustainability agenda.