Miracle-dz/UniFAR-FTUs huggingface dataset:
PLGA-Quercetin Nano-Formulation Inhibits Cancer Progression via Mitochondrial Dependent Caspase-3,7 and Independent FoxO1 Activation with Concomitant PI3K/AKT Suppression

Quercetin is one of the most important plant flavanols, having several pharmacological and biological uses. Quercetin (Q) is an extremely hydrophobic phytochemical and has poor intracellular absorption, which makes its use limited. Present research demonstrates that quercetin-loaded PLGA nanoparticles (PLGA-QNPs) could overcome its low hydrophilicity and improve its anti-cancer potential. PLGA nanoparticles loaded with Q were prepared by the solvent evaporation technique and its anticancer activity was examined in vitro as well as in vivo. The cell viability was assessed through MTT assay and apoptosis was assayed through Hoechst-PI and EB/AO double staining followed by mitochondrial damage through Mito-tracker RMX-Ros. Gene expression was examined through RT-PCR. Cell cycle arrest in G2/M phase was analyzed through FACS. The results obtained revealed that PLGA-QNPs significantly reduced the viability of human cervical and breast cancer cell lines. PLGA-QNPs induced apoptosis in human cervical cancer cells in a dose dependent manner. The gene expression of PI3K/AKT was down-regulated and FoxO1 was upregulated in PLGA-QNP-treated cells, which showed a high expression level of active Caspase-3 and 7, which are responsible for apoptosis. In addition, PLGA-QNPs reduced the average number of tumors and prolonged the tumor latency period in DMBA-induced mammary adenocarcinoma SD rats. These findings suggest that PLGA-QNPs inhibit cervical and breast cancer progression via mitochondrial dependent Caspase-3 and 7 and mitochondrial independent FoxO1 activation with concomitant suppression of the PI3K/AKT pathway. For future studies, we suggest that potential druggability efficacy and clinical development of anticancer PLGA-QNPs need to be evaluated intensely for successful anticancer drug development.
“No Ink on Tumor” in Breast-Conserving Surgery after Neoadjuvant Chemotherapy

Background/Aim: Patients with Stage I-II breast cancer undergoing breast-conserving surgery after neoadjuvant chemotherapy (BCS-NAC) were retrospectively assessed in order to evaluate the extent of a safe excision margin. Materials and Methods: Between 2003 and 2020, 151 patients underwent risk-adapted BCS-NAC; margin involvement was always assessed at definitive histology. Patients with complete pathological response (pCR) were classified as the RX group, whereas those with residual disease and negative margins were stratified as R0 < 1 mm (margin < 1 mm) and R0 > 1 mm (margin > 1 mm). Results: Totals of 29 (19.2%), 64 (42.4%), and 58 patients (38.4%) were included in the R0 < 1 mm, R0 > 1 mm, and RX groups, respectively, and 2 patients with margin involvement had a mastectomy. Ten instances of local recurrence (6.6%) occurred, with no statistically significant difference in local recurrence-free survival (LRFS) between the three groups. A statistically significant advantage of disease-free survival (p = 0.002) and overall survival (p = 0.010) was observed in patients with pCR. Conclusions: BCS-NAC was increased, especially in HER-2-positive and triple-negative tumors; risk-adapted BCS should be preferably pursued to highlight the cosmetic benefit of NAC. The similar rate of LRFS in the three groups of patients suggests a shift toward the “no ink on tumor” paradigm for patients undergoing BCS-NAC.
Image-based 3D reconstruction for rail profile measurement

The routine inspection of railheads for defects such as wear and surface cracks is a tedious process, which, if not detected, can alter the wheel-rail contact interaction leading to catastrophic events. This study investigates and implements a railhead measurement method using image-based three-dimensional reconstruction, which enables rapid scanning of railheads and production of detail cross-sectional measurements for rail-wheel interface analysis. A complete workflow with a methodology for reconstructing railheads from images and extracting cross-sectional measurements from the reconstructed model is presented. In order to validate the proposed method in the field, a mobile automated system was equipped with an array of cameras specifically spaced to cover the areas of interest on the railhead. The system can automatically transverse along the railhead, acquiring images synchronously. Two case studies in the laboratory environment and the real railway site have been performed to evaluate the performance and accuracy against industry practices. The results show that the proposed method can accurately measure the railhead cross-sectional profile at an root mean square error (RMSE) less than 0.3 mm compared with MiniProf. Furthermore, continuous cross-sectional data and intuitive color information are provided by our method which can help inspectors to locate defects easily and more efficiently.
Horizontal collaborative transport: survey of solutions and practical implementation issues

Horizontal collaboration has been considered as effective practice for sustainable logistics and freight transport and it has gained increased attention in recent years. This paper aims to provide a survey of the development of horizontal collaborative transport (HCT) over the past ten years, to identify research trends and gaps, then to propose some research opportunities. The paper also aims to provide guidelines to logistics companies who wish to embark on HCT, to help them choose which HCT solution to implement. To provide a comprehensive and structured review, the paper follows the methodology for Systematic Literature Review proposed in the literature. A total of 120 scientific papers published between 2007 and 2017 were reviewed. A survey framework based on two axes – HCT solutions and implementation issues – is developed to analyse and position the papers. The results show that, regarding HCT solutions, carrier alliance and flow controller collaboration were the most frequently studied. But recent innovative solutions such as pooling and physical internet are also gaining increased attention. Regarding implementation issues, the focus of the literature has been on the development of decision-making models, including transport planning, lane exchange, and gain sharing. Conversely, managerial and technological issues have received less attention.
Challenges in the management of patients with pulmonary embolism in Brazil

thromboembolism a disease that (29-78 the causes of cardiovascular death in the three (2) it is to understand the economic impact of PTE and the factors involved in its prognosis. In the current issue of the Brasileiro Pneumologia (JBP), an epidemiological study shows relevant data on the number of hospitalizations for PTE, costs of PTE treatment, and mortality of PTE in the five regions of (3) The risk of PTE increases with age, as does the risk of common aging-related comorbidities such as cardiovascular disease, chronic lung disease, and cancer. (4,5) Aging and age-related comorbidities contribute to increased length of hospital stay, costs, and risk of morbidity and mortality from thromboembolic events. (4) the increase in life expectancy in recent decades, with the aging rate in Brazil having increased by 268% from 1970 to 2010, in the southern and southeastern regions of the the number of hospital for PTE has the mean number of hospitalizations was in and
High resolution observations of a selection of faint 1.4GHz radio counterparts to optical sources in the HDF-N

We present recent results from very deep MERLIN/VLA 1.4GHz observations of an 8.5-by-8.5 arcminute field centred on the the Hubble Deep Field North, in conjunction with BVIz catalogues of GOODS/ACS sources detected in this field. In an extension of work by Muxlow et al. (also presented at this conference) on the statistical properties of over 8000 sources, the results presented here take advantage of the deep (rms: 3.3 microJy/bm), sub-arcsecond radio imaging of this field to characterise the properties at 1.4GHz of a number of individual radio counterparts to GOODS/ACS sources.
Silencing of the Ca2+ Channel ORAI1 Improves the Multi-Systemic Phenotype of Tubular Aggregate Myopathy (TAM) and Stormorken Syndrome (STRMK) in Mice

Tubular aggregate myopathy (TAM) and Stormorken syndrome (STRMK) form a clinical continuum associating progressive muscle weakness with additional multi-systemic anomalies of the bones, skin, spleen, and platelets. TAM/STRMK arises from excessive extracellular Ca2+ entry due to gain-of-function mutations in the Ca2+ sensor STIM1 or the Ca2+ channel ORAI1. Currently, no treatment is available. Here we assessed the therapeutic potential of ORAI1 downregulation to anticipate and reverse disease development in a faithful mouse model carrying the most common TAM/STRMK mutation and recapitulating the main signs of the human disorder. To this aim, we crossed Stim1R304W/+ mice with Orai1+/− mice expressing 50% of ORAI1. Systematic phenotyping of the offspring revealed that the Stim1R304W/+Orai1+/− mice were born with a normalized ratio and showed improved postnatal growth, bone architecture, and partly ameliorated muscle function and structure compared with their Stim1R304W/+ littermates. We also produced AAV particles containing Orai1-specific shRNAs, and intramuscular injections of Stim1R304W/+ mice improved the skeletal muscle contraction and relaxation properties, while muscle histology remained unchanged. Altogether, we provide the proof-of-concept that Orai1 silencing partially prevents the development of the multi-systemic TAM/STRMK phenotype in mice, and we also established an approach to target Orai1 expression in postnatal tissues.
ITERATED FUNCTION SYSTEMS WITH PLACE-DEPENDENT PROBABILITIES AND THE INVERSE PROBLEM OF MEASURE APPROXIMATION USING MOMENTS

We are concerned with the approximation of probability measures on a compact metric space ( X, d ) by invariant measures of iterated function systems with place-dependent probabilities (IFSPDP). The approximation is performed by moment matching. Associated with an IFSPDP ifspdpwsc-1 is a linear operator A : D ( X ) → D ( X ), where D ( X ) denotes the set of all inﬁnite moment vectors of probability measures on X . Let µ be a probability measure that we desire to approximate, with moment vector g = ( g 0 , g 1 , · · · ). We then look for an IFSPDP which maps g as close to itself as possible in terms of an appropriate metric on D ( X ). Some computational results are presented.
The Effect of Diffuse Radiation on Ecosystem Carbon Fluxes Across China From FLUXNET Forest Observations

Aerosol loading and cloud cover can alter the composition of radiation reaching the Earth’s surface and affect the ecosystem’s carbon cycle. In this study, we established an empirical model of the diffuse radiation fraction (Kd) based on a clearness index (Kt) to obtain the Kd of four FLUXNET forest sites in China. We focused on the relationships among the Kd, photosynthetically active radiation (PAR), light-use efficiency (LUE) and gross primary productivity (GPP) through mechanistic analysis. The relationships between carbon fluxes [including GPP, ecosystem respiration (ER), and net ecosystem exchange (NEE)] and the Kd were explored. Furthermore, we investigated the influence of environmental factors on carbon fluxes. The results showed that the Kd models were accurate in estimating Kd (R2= 0.88–0.93). Overall, the GPP first increased and then decreased with increasing Kd. When Kd< Ko (Ko, the diffuse radiation fraction corresponding to the maximum value of GPP), the direct PAR decreased as Kd increased, while the diffuse PAR increased rapidly. At this stage, the diffuse fertilization effect led to an increase in GPP. When Ko<Kd<Kdiff-max (Kdiff-max, the diffuse radiation fraction corresponding to the maximum value of diffuse PAR), as Kd increased the direct PAR still decreased and the diffuse PAR still increased, but the GPP declined. When Kd>Kdiff-max, the diffuse PAR began to decrease, and the reduction in the superimposed direct PAR caused the GPP of the canopy to drop rapidly. The LUE of the vegetation canopy was higher under diffuse light conditions than under direct light. Furthermore, with an increase in the Kd, the negative value change of the NEE was consistent with the GPP, but the ER was less affected by the Kd. Finally, the impact of temperature (TA) and vapor pressure deficit (VPD) on the GPP was unimodal, and the impact on the NEE was U-shaped. In addition, latent heat (LE) had a significant positive effect on GPP and NEE. Our study emphasized the relationship between the change in PAR composition and the Kd, as well as its impact on the carbon fluxes change, which is highly important to the study of carbon neutralization.
Climate warming shortens ice durations and alters freeze and break-up patterns in Swedish water bodies

Abstract. Increasing air temperatures reduce the duration of ice cover on lakes and rivers, threatening to alter their water quality, ecology, biodiversity, and physical, economical and recreational function. Using a unique in situ record of freeze and break-up dates, including records dating back to the beginning of the 18th century, we analyze changes in ice duration (i.e., first freeze to last break-up), freeze and break-up patterns across Sweden. Results indicate a significant trend in shorter ice duration (62 %), later freeze (36 %) and earlier break-up (58 %) dates from 1913–2014. In the latter 3 decades (1985–2014), the mean observed ice durations have decreased by about 11 d in northern (above 60∘ N) and 28 d in southern Sweden relative to the earlier three decades. In the same period, the average freeze date occurred about 10 d later and break-up date about 17 d earlier in southern Sweden. The rate of change is roughly twice as large in southern Sweden as in the northern part. Sweden has experienced an increase in occurrence of years with an extremely short ice cover duration (i.e., less than 50 d), which occurred about 8 times more often in southern Sweden than previously observed. Our analysis indicates that even a 1 ∘C increase in air temperatures in southern (northern) Sweden results in a mean decrease of ice duration of 22.5 (±7.6) d. Given that warming is expected to continue across Sweden during the 21st century, we expect increasingly significant impacts on ice cover duration and hence, ecology, water quality, transportation, and recreational activities in the region.
Paediatric differentiated thyroid carcinoma: a UK National Clinical Practice Consensus Guideline

This guideline is written as a reference document for clinicians presented with the challenge of managing paediatric patients with differentiated thyroid carcinoma up to the age of 19 years. Care of paediatric patients with differentiated thyroid carcinoma differs in key aspects from that of adults, and there have been several recent developments in the care pathways for this condition; this guideline has sought to identify and attend to these areas. It addresses the presentation, clinical assessment, diagnosis, management (both surgical and medical), genetic counselling, follow-up and prognosis of affected patients. The guideline development group formed of a multi-disciplinary panel of sub-speciality experts carried out a systematic primary literature review and Delphi Consensus exercise. The guideline was developed in accordance with The Appraisal of Guidelines Research and Evaluation Instrument II criteria, with input from stakeholders including charities and patient groups. Based on scientific evidence and expert opinion, 58 recommendations have been collected to produce a clear, pragmatic set of management guidelines. It is intended as an evidence base for future optimal management and to improve the quality of clinical care of paediatric patients with differentiated thyroid carcinoma.
Reduced grip strength potentially indicates depression: Investigating multicontinental databases.

BACKGROUND Multi-national studies in the association between handgrip strength and depression in middle and older aged adults are limited. Hence, Brazil, China, Europe, Korea, United Kingdom (UK) and United States (US) datasets were utilized to investigate this association. METHODS A cross-sectional study was conducted with 51,285 participants aged >45 years. Handgrip strength scores were divided into quartiles, groups 1 (highest) to 4 (lowest) in each database, and depression measures converted to binary scores. RESULTS Males in China and UK reported higher adjusted odds ratios (aORs) of depression for groups 2, 3, and 4 than for group 1. Brazil, US, and Korea reported greater aORs in groups 3 and 4 whereas Europe demonstrated increased aORs for group 4 only. Among females, China, Brazil, US, and Korea showed high aORs across all groups, while UK and Europe reported increased aORs for group 4 only. Highest ORs were reported from Korea in group 4 for males (aOR: 3·09; 95 % CI: 2·15-4·43; p < 0·001) and females (aOR: 3·74; 95 % CI: 2·78-5·03; p < 0·001). When removing the regional factor, aORs were higher in lower groups, with the highest reported from group 4 for males (aOR: 2·32; 95 % CI: 2·09-2·58; p < 0·001) and females (aOR: 2·11; 95 % CI: 1·95-2·29; p < 0·001). LIMITATIONS Being a cross-sectional study, the results were not able to establish the causal direction between handgrip strength and depression. CONCLUSION Lower handgrip strength was associated with an increased likelihood of depression. Early assessment of handgrip strength may identify populations at-risk for depression among middle and older aged adults.
Valued living among veterans in breath-based meditation treatment or cognitive processing therapy for posttraumatic stress disorder: Exploratory outcome of a randomized controlled trial

Background Valued living is the extent to which an individual’s behavior is consistent with what they believe is important or good. It is unknown whether many complementary and integrative treatments and psychotherapies for posttraumatic stress disorder enhance valued living, and for whom. Objectives Measure within- and between-group changes in valued living in Veterans who completed cognitive processing therapy (CPT) and sudarshan kriya yoga (SKY) for posttraumatic stress disorder (PTSD); evaluate moderators of improvement. Methods Participants with clinically significant symptoms of PTSD were assigned to CPT, a first line, evidence-based psychotherapy for PTSD or SKY, an emerging breath-based meditation with strong preliminary empirical support in a parallel-groups randomized controlled trial at a single Veterans Affairs healthcare center. The Valuing Questionnaire subscales for progress in valued living (VQ-P) and obstruction in valued living (VQ-O) were exploratory outcome measures. Assessors were blind to treatment assignment. Results 59 participants completed treatment (29 CPT, 30 SKY). Participants in the CPT group improved from baseline to end of treatment in both VQ-Progress (d=0.55, p=0.02) and VQ–Obstruction (d=-0.51, p=0.03), while the SKY group did not improve on either subscale (d=0.08, p=0.69; d=0.00, p=1.00). However, differences between treatments were not statistically significant (p=0.16, 0.11, respectively). Participants reporting less valued living and more depression symptoms at baseline reported greater improvements in valued living following treatment. Conclusion CPT may have a positive effect on valued living. Individuals lower in valued living and with more depression may derive relatively more benefit.
E-Cloud: Efficient seismic fragility assessment of structures based on enhanced cloud analysis

Cloud analysis is based on linear regression in the logarithmic space using least squares, in which a large number of nonlinear dynamic analyses are required to ensure the regression accuracy. Thus, it needs significant computational effort to derive fragility curves especially for the complicated structures. This article proposed the Enhanced Cloud approach (E-Cloud) to enhance the efficiency but maintain the accuracy of Cloud analysis. The basic concept of the E-Cloud method aims to utilize both maximum and additional seismic responses with corresponding intensity measures (IMs) from ground motions for the logarithmic linear regression in Cloud analysis. The additional seismic responses can be obtained from the engineering demand parameter (EDP)-IM curve, which is generated at the specific time duration when structures are subjected to intensifying dynamic excitations in nonlinear time–history analysis. The required number of nonlinear time–history analyses in Cloud analysis is reduced since additional seismic responses (with their corresponding IM value) are used as additional Cloud points for the Cloud regression. The proposed E-Cloud method is applied for the case study of a typical reinforced concrete (RC) frame structure. By comparison of probabilistic seismic demand models and fragility curves from the E-Cloud method to Cloud analysis, it is demonstrated that the proposed E-Cloud method can significantly improve the computational efficiency of the Cloud analysis, which also leads to accurate fragility estimates of the structures.
Monitoring System for Plasma-Electrolyte Synthesis of Oxides, Which Are the Functional Medium of Resistive Switching in Metal-Oxide-Metal Structures

The paper considers the possibility of using the plasma-electrolyte synthesis technology for the oxide layers formation intended for the structures with the resistive switching effect (memristors) obtain. It is shown that to study the formation of not typical for this class of electrolytic-plasma processes a nanoscale thickness oxide layers, a special organization of joint the technological current source and the monitoring system operation (synchronous start mode) is required. The monitoring system equipment that implements this operation mode is described. As a result, an example of new method for studying the plasma processes initialization based on the developed synchronized data acquisition method and high-speed video recording is given, which makes it possible to determine with high accuracy the forming pulses electrical characteristic instantaneous values fixation moment and compare them with the treated surface video image.
Predictive competitive intelligence with prerelease online search traffic

In today's competitive market environment, it is vital for companies to gain insight about competitors' new product launches. Past studies have demonstrated the predictive value of prerelease online search traffic (PROST) for new product forecasting. Relying on these findings and the public availability of PROST, we investigate its usefulness for estimating sales of competing products. We propose a model for predicting the success of competitors' product launches, based on own past product sales data and competitor's prerelease Google Trends. We find that PROST increases predictive accuracy by more than 18% compared to models that only use internally available sales data and product characteristics of video game sales. We conclude that this inexpensive source of competitive intelligence can be helpful when managing the marketing mix and planning new product releases.