Miracle-dz/UniFAR-FTUs huggingface dataset:
Management of pregnancy-related hemophagocytic lymphohistiocytosis CURRENT STATUS: UNDER REVIEW

Background: Pregnancy-related hemophagocytic lymphohistiocytosis (HLH) is rare, diagnosing HLH in pregnancy is difficult. There is currently no consensus on the treatment of pregnancy-related HLH. We aim to analyze and summarize the clinical characteristics of pregnancy-related HLH, and to discuss effective diagnostic and treatment options. Methods: Thirteen patients with pregnancy-related HLH who were diagnosed and treated at the Peking Union Medical College Hospital of the Chinese Academy of Medical Sciences from January 2000 to December 2019 were studied retrospectively. We collected data on treatment regimens and on maternal and pregnancy outcomes. Results: All patients had a singleton pregnancy, with a median age of 28 years (range, 22–33 years) and a median gestational age of 23 weeks (8–36 weeks). There were underlying associated diagnoses in 6 patients; of the patients, 12 (92.3%, 12/13) were treated with corticosteroids, and a good efficiency was achieved in 5 (41.7%, 5/12) of them, including 3 complicated by autoimmune diseases. Two patients completed their pregnancies, and the conditions of 2 patients were alleviated with dexamethasone and etoposide treatment. Four pregnant women died (all multiparas), and the mortality rate was 30.77% (4/13). Fetal or neonatal death up to 1 week after delivery occurred in 8 (61.54%) pregnancies, and there were 4 cases of miscarriage, 2 of stillbirth, and 2 of neonatal death. Complications also included premature birth (57.14% of neonates), small for gestational age (SGA, 7.70%), premature rupture of membranes (15.38%), and fetal stress (15.38%). The maternal mortality rates of patients in the first, second, and third trimesters of pregnancy were 100% (1/1), 14.29% (1/7), and 40% (2/5) ( P = 0.129), respectively, and the fetal or neonatal death rates in the trimesters were 100% (1/1), 85.71% (6/7),
Their Ability To Secrete Chemokines Myeloid Cell Recruitment into the Lung and Regulate Early Lipopolysaccharide-Induced The Src-Family Kinases Hck and Fgr

Myeloid leukocyte recruitment into the lung in response to environmental cues represents a key factor for the induction of lung damage. We report that Hck- and Fgr-deﬁcient mice show a profound impairment in early recruitment of neutrophils and monocytes in response to bacterial LPS. The reduction in interstitial and airway neutrophil recruitment was not due to a cell-intrinsic migratory defect, because Hck- and Fgr-deﬁcient neutrophils were attracted to the airways by the chemokine CXCL2 as wild type cells. However, early accumulation of chemokines and TNF- a in the airways was reduced in hck 2 / 2 fgr 2 / 2 mice. Considering that chemokine and TNF- a release into the airways was neutrophil independent, as suggested by a comparison between control and neutrophil-depleted mice, we examined LPS-induced chemokine secretion by neutrophils and macrophages in wild type and mutant cells. Notably, mutant neutrophils displayed a marked deﬁcit in their capability to release the chemokines CXCL1, CXCL2, CCL3, and CCL4 and TNF- a in response to LPS. However, intracellular accumulation of these chemokines and TNF- a , as well as secretion of a wide array of cytokines, including IL-1 a , IL-1 b , IL-6, and IL-10, by hck 2 / 2 fgr 2 / 2 neutrophils was normal. Intriguingly, secretion of CXCL1, CXCL2, CCL2, CCL3, CCL4, RANTES, and TNF- a , but not IL-1 a , IL-1 b , IL-6, IL-10, and GM-CSF, was also markedly reduced in bone marrow–derived macrophages. Consistently, the Src kinase inhibitors PP2 and dasatinib reduced chemokine secretion by neutrophils and bone marrow–derived macrophages. These ﬁndings identify Src kinases as a critical regulator of chemokine secretion in myeloid leukocytes during lung inﬂammation. The Journal of Immunology , 2015, 195: 000–000.
EFFECTIVENESS OF A SCAPULOTHORACIC AND GLENOHUMERAL STABILIZATION EXERCISE PROTOCOL IN BOULDERERS: A RANDOMIZED CLINICAL TRIAL.

T Background: Athletic performance of bouldering climbers largely depends on shoulder stability, the climber's speed of movement and the number of grips using the upper limbs. The objective was to assess the effectiveness of two shoulder stabilization exercise programs in climbers. 40 climbers were randomized to two groups: Experimental Group undergoing a glenohumeral and scapulothoracic stability exercise program, and Control Group performing glenohumeral stabilization exercises. Assessments were performed by a blinded physiotherapist at baseline, at 4 weeks, and after a 4-week follow-up period. The primary variable was shoulder stability (Closed Kinetic Chain Upper Extremity Stability Test). Athletic performance was also measured, this being the time required to complete a climb and number of grips needed (Climbing test). Shoulder stability increased significantly from baseline to following the intervention and follow-up. Shoulder stability in the control group improved significantly from the pretreatment evaluation to after the intervention. There were intra-subject differences in shoulder stability (F = 14.63; p <.001), time needed to complete a given climbing route (F = 14.98; p <.001) and number of grips required (F = 10.08; p <.01). There were significant differences between treatment groups at any time measured in joint stability (F = 7.41; p <.01), time needed to complete a given climb (F = 8.17; p <.01) and the number of grips made (F = 5.13; p = .02). A glenohumeral and scapulothoracic stability exercise intervention achieved significant differences in shoulder stability and athletic performance in boulderers.
Effect of evening primrose oil on primeralary blood coagulation investigation in male rabbits

This study was performed to determine the effects of Evening primrose oil (EPO) on haemostatic parameters following 30 and 60 days administration of 90 mg/kg (EPO) to healthy male rabbits. The laboratory resulting in significant increase in Prothrombin time (PT), activated partial thromboplastin time (aPTT) assays (p<0.01), platelets count significantly decreased (p<0.01) at both times. While fibrinogen concentration are insignificantly decreased. These effects might be due to inactivation or inhibition of factors affecting coagulation.
Pfizer Vaccine Tweet Sentiment Analysis

: From the WHO pandemic declaration and government-initiated actions against coronavirus illness (COVID-19), sentiments close COVID-19 have evolved speedily. This article provides associate degree analysis on however individuals react to an outbreak, what quantity they're tuned in to the illness and its symptoms, what preventive measures they're taking and whether or not individuals are following government’s tips and guidelines etc. Understanding the posts on social media pages throughout an outbreak permits health agencies and volunteers to higher assess and perceive the public's insolences, sentiments and desires so as to deliver applicable and effective data. - This study aimed to examine worldwide trends of four emotions—fear, anger, sadness, and joy—and the narratives underlying those emotions during the COVID-19 pandemic, and the effectiveness of the Pfizer vaccine. II. Methods: - Almost a million social media tweet posts made during the early phases of the COVID-19 outbreak and were collected using various kinds of keywords like “Wuhan,” “corona,” “nCov”, ‘’vaccine’’,” Pfizer” and “covid” as search keywords. The potential animal hosts of SARS-CoV, MERS-CoV, and SARS-CoV-2 Were summarized Notably, the outbreaks of those hCoVs square measure associated with interactions between humans and animals, especially, each SARS-CoV and SARS-CoV-2 emerge from wet markets in China. Considering early severe acute respiratory syndrome patients were related to wild animal markets in the province, SARS-CoV was thought to emerge from wild animals (included palm civets) that were sold in these markets. afterward, a strain of CoV shared extremely homologous similarity to SARS-CoV (99.8%) was isolated from palm civets from wild animal markets, therefore palm civets-derived CoVs were believed to be able to switch their hosts to human, inflicting the human-to-human transmission. to boot, the development that some severe acute respiratory syndrome patients (3/4) had had a transparent contact history with palm civets throughout the discontinuous occurred in the province was noticed, thereby epidemiologically supporting the previous assumption that palm civets act as vital animal hosts of SARS-CoV. Thus, it's cheap to believe that palm civets were vital intermediate hosts for SARS-CoV supported this robust proof. afterward, students found that palm civets on farms square measure for the most part free from SARS-CoV infection whereas about eightieth of the civets sold in AN animal market was serologically positive (high level of SARS-CoV antibody), indicating that no widespread infection in wild civets. Thus, palm civets became the intermediate hosts of SARS-CoV in all probability by obtaining infected throughout trade activities in or before reaching these wet markets Afterward, strain of SARS-like- CoV isolated horseshoe nuts, sharing 88–92% genomic identity to CoVs viverrine powerfully nuts square
Global exponential stability and existence of anti-periodic solutions to impulsive Cohen-Grossberg neural networks on time scales

By using the method of coincidence degree theory and Lyapunov functions, some new criteria are established for the existence and global exponential stability of anti-periodic solutions to impulsive Cohen-Grossberg neural networks on time scales. Our results are new even if the time scale $\mathbb{T}=\mathbb{R}$ or $\mathbb{Z}$. Finally, an example is given to illustrate our results.
Study of ECG changes in anaemia and correlation with respect to severity of anaemia

Introduction: Anemia has a universal incidence and is very common in tropical countries. The most common cause of anemia is iron deficiency associated with hypochromic microcytic anemia. Chronic Anemia is associated with increased cardiac output when Hb is < 7g/dl. When Hb falls further (2-3gms/100ml) there will be circulatory congestion and angina pectoris may occur thus emphasizing the sensitivity of the myocardium to chronic hypoxia leading to various changes in the electrocardiographic recording. Materials and methods: 100 patients comprising of both outpatient and inpatients attending JJMMC and its attached hospital from July 2017 to May 2018 were selected based on inclusion criteria which includes cases of anemia i.e. Hb < 8 gm% and those aged < 40% because to reduce changes of taking up coronary artery disease patients (both males and females). Results: Out of 100 cases of severe anemia 52 cases showed ECG changes. 23 patients were having Hb < 6 gm % with 78% of whom had ECG Changes. Sinus tachycardia was the most common ECG change observed accounting to 41% and sinus bradycardia and biventricular hypertrophy were the least observed ECG finding among study population (1% each). In present study cases, only 13 patients had reversal of ECG changes after correction. Conclusion: I) Severe anemia produces ECG changes, which mainly involve the rate, ST segment and T wave changes. II) The incidence of ECG changes seemed to be closely related to severity of anemia.
Blood groups and COVID-19: Exploring the link

The SARS COVID-19 pandemic took the whole world by storm due to its high and rapid infectivity. As it spread, its patterns became clear, and it became evident that a few individuals were more predisposed to it than others. Showing a massive inflammatory response by the body, and a negative coagulative affect, doctors and scientists began to perceive the role of blood cells, and hence blood types in the disease process. This lead to the main objective of this research: to assess the link between COVID19 infection and blood group types, and follow disease outcome according to it. The study comprises data collected from patients within 3 hospital setting of Northern Pakistan, viz Military Hospital Rawalpindi, Benazir Bhutto Hospital Rawalpindi, and Pakistan institute of medical sciences Islamabad. The study was conducted during a period of 1 month i-e from 15th June 2020 to 15th July 2020 after approval by the worthy Ethical review committee of PEMH. The study design was Analytical- Case series. Purposive Sampling technique was used. The sample size was 306 based on WHO sample calculator. Patients who were PCR positive and symptomatic for COVID-19 were included whereas PCR negative and asymptomatic patients were excluded. SPSS version 25 was used to process the data and Graphs and Charts were used to explain it. Among 306 patients of COVID 19 the most commonly affected blood group was A+ve followed by B+ve. The least affected blood group was O of which both positive and negative contributed to 17.71%. A blood group contributed 36%, while B 35% and AB 10.8%. The study substantiates that blood group A Rh positive has more susceptibility for SARS COVID-19 infection than other blood group types. Blood group O might have a protective effect against this infection.
In vitro Antimicrobial Activities and Phytochemical Analysis of Morinda Tinctoria (L) Leaf Extracts

Plants have been one of the important sources of medicines since the beginning of human civilization. There is a growing demand for plant based medicines, health products, pharmaceuticals, food supplements and cosmetics. Morinda tinctoria (L) belonging to the family Rubiaceae, commercially known as Nunaa are used in folkloric medicine for the treatment of various diseases. Leaves, roots and fruits of M. tinctoria (L) are used as an astringent, deobstruent and to treat different kinds of illness such as arthritis, cancer, gastric ulcer, gout, heart diseases etc. The ashes of M. tinctoria (L) leaves are also reported to act as biosorbents in controlling ammonia pollution in waste waters. This article intends to provide an overview of the chemical constituents present in the crude leaf extracts of M. tinctoria (L) with special emphasis on their pharmacological actions. A comparative antimicrobial activity of dried leaf extracts of M. tinctoria were evaluated against two gram negative bacterial strains namely Escherichia coli and Pseudomonas aeroginosa and two clinical fungal pathogens namely Candida albicans and Aspergillus niger by agar cup assay method. Qualitative phytochemical screening was carried out using the crude leaf extracts in three different solvents such as water, acetone and chloroform. Phytochemical analysis of the extracts revealed the presence of glycosides, alkaloids, essential oils, sapponins etc. The ethanol leaf extracts of M. tinctoria was found to have high antibacterial activity than anti fungal activity. The results suggest that the leaves are a rich source of valuable primary and secondary metabolites exhibiting the antimicrobial activity.
OP-NARE121044 2769..2778

Zinc-finger nucleases (ZFNs) and TAL effector nucleases (TALENs) have been shown to induce targeted mutations, but they have not been extensively tested in any animal model. Here, we describe a large-scale comparison of ZFN and TALEN mutagenicity in zebrafish. Using deep sequencing, we found that TALENs are significantly more likely to be mutagenic and induce an average of 10-fold more mutations than ZFNs. We observed a strong correlation between somatic and germ-line mutagenicity, and identified germ line mutations using ZFNs whose somatic mutations rates are well below the commonly used threshold of 1%. Guidelines that have previously been proposed to predict optimal ZFN and TALEN target sites did not predict mutagenicity in vivo. However, we observed a significant negative correlation between TALEN mutagenicity and the number of CpG repeats in TALEN target sites, suggesting that target site methylation may explain the poor mutagenicity of some TALENs in vivo. The higher mutation rates and ability to target essentially any sequence make TALENs the superior technology for targeted mutagenesis in zebrafish, and likely other animal models.
Synthesis and Mössbauer studies on Nickel-Zinc-Copper nanoferrites

- Polycrystalline Ni-Zn ferrite, with a well-defined composition, Ni 0.6 Zn 0.4 Fe 2 O 4 , synthesized by a low temperature method showed the formation of a cubic ferrite phase with a crystallite size of ~15 nm and saturation magnetization of M s ≈ 44 emu/g at room temperature. When calcined at higher temperatures (up to 1200 °C) the magnetization increased continuously to M s ≈ 67 emu/g. To understand the magnetic nature of the cubic ferrite phase formed at a temperature as low as 80°C, 57 Fe Mössbauer spectra were recorded for samples annealed at three different temperatures, without any external magnetic field, and with an external field of H ext = 5 T, at 4.2 K. The spectral parameters at room temperature, namely, isomer shift, quadrupole splitting and hyperfine field, confirmed the presence of ultrafine superparamagnetic crystallites of Ni-Zn ferrite. The Mössbauer spectra at 4.2 K revealed spin relaxation effects resulting in very broad sextets, characteristic of ultrafine crystallites. The Mössbauer spectra recorded at 4.2 K and H ext =5T showed well-resolved two-sextet pattern with characteristic hyperfine interaction parameters of the cubic ferrite phase.
A Gibberellin Response Complex in Cereal a-Amylase Gene Promoters

The Amy32b gene is a representative member of a closely related family of a-amylase genes expressed under hormonal control in aleurone layers of barley grains. Transcription of this gene is induced by gibberellin (GA) and suppressed by abscisic acid. In this study, we functionally defined the promoter elements of the Amy32b gene that govern the developmental and hormonal control of its expression in aleurone. Two functionally distinct yet physically associated elements are essential: a gibberellin response element mediates regulation by GA and abscisic acid, and an Opaque-2 binding sequence (02s) is thought to interact with a barley homolog of the maize endosperm-specific transcriptional regulator Opaque-2. An additional element CCTTTT, which with the 02s forms part of a canonical =endosperm box,” is important in modulating the absolute leve1 of expression of the Amy32b promoter, as is another separate, highly consenred element TATCCATGCAGTG.
Recursive Least Square Based Reduced-Rank Blind Channel Estimation Algorithm for CDMA Systems

Generally, the high speed data transmission and reliable communication systems is often desired. For this reason, the channel estimation becomes an important topic in the communication community. In the last few decades, many works have done over the reduced-rank channel estimation approaches. Although many of them provide good performance but they incur high computational complexity, so it is infeasible to implement in real-time. In this paper, we proposed an adaptive recursive least square based reduced-rank channel estimation algorithm for code division multiple access systems. The performance of this algorithm is compared with the full-rank recursive least square algorithm.
Information Technology and Electrical Engineering - Devices and Systems, Materials and Technologies for the Future

According to the EU objectives there are national plans to increase the share of electricity produced by renewable energy sources (RES) significantly. The German Renewable Energy Sources Act (“Erneuerbare-Energien-Gesetz” – EEG) claims for priority purchase and transmission of, and payment for electricity from RES by the transmission system operators (TSO). The allocation of purchased and paid RES electricity is regulated by means of a nation-wide equalization scheme. According to this scheme TSOs are obliged to deliver the fluctuating electricity infeeds from RES to the utilities serving the final customers in the form of monthly constant bands. In order to compensate the stochastic RES-infeeds fluctuations, the TSO needs to purchase or dispose RES-electricity on the market. This paper is a research continuation of the authors’ previous paper [1], and describes a decision support tool (DST) developed to assist the TSO in its obligation of “sublimation” (compensation) of the fluctuating RES-electricity infeeds. With help of its different modules it provides the possibility to “learn” an optimal strategy for an efficient appearance on the electricity market.
The NA62 GigaTracker

The GigaTracker is a hybrid silicon pixel detector built for the NA62 experiment aiming at measuring the branching fraction of the ultra-rare kaon decay K+→π+νν¯ at the CERN SPS. The detector has to track particles in a beam with a flux reaching 1.3 MHz/mm2 and provide single-hit timing with 200 ps RMS resolution for a total material budget of less than 0.5% X0 per station. The tracker comprises three 60.8 mm×27 mm stations installed in vacuum (∼10−6mbar) and cooled with liquid C6F14 circulating through micro-channels etched inside a few hundred micron thick silicon plates. Each station is composed of a 200 μm thick silicon sensor read out by 2×5 custom 100 μm thick ASICs, called TDCPix. Each chip contains 40×45 asynchronous pixels, 300 μm×300 μm each and is instrumented with 100 ps bin time-to-digital converters. In order to cope with the high rate, the TDCPix is equipped with four 3.2 Gb/s serialisers sending out the data. We will describe the detector and the results from the 2014 and 2015 NA62 runs.
Statistical Modeling via Bootstrapping and Weighted Techniques Based on Variances

Multiple logistic regression is a methodology of handling dependent variables with a binary outcome. This method is becoming increasingly widespread as a statistical technique that represents a discrete probability model. Many studies have focused on the application but less on the methodology building. This study aims to provide an applied method for multiple logistic regression which is called modified Bayesian logistic regression modeling as an alternative technique for logistic regression analysis that focuses on a combination of the bootstrap method using SAS macro and weighted techniques based on variances using SAS algorithm. Data on oral cancer were applied to illustrate a real scenario of oral health data. This data will be applied to the multiple logistic regression algorithm and modified Bayesian logistic regression. Results from both cases are strongly supported by clinical studies. Through the proposed algorithm, the researcher will have an option whether to analyze the data with the usual or an alternative method. Final results indicate that the modified procedure can provide more efficient results especially for the case which involves statistical inferences.
CO2 Price Volatility Effects on Optimal Power System Portfolios

This paper investigates the effects of CO2 price volatility on optimal power system portfolios and on CO2 emissions assessment. In a stochastic setting in which three sources of uncertainty are considered, namely fossil fuels (gas and coal) and CO2 prices, we discuss a unifying scheme for quantifying the impact of integrated environmental and renewable energy policies on the power system. We will show that the effects produced by a given environmental policy scheme strongly depend on the configuration of the power system, i.e., on the composition of the generating sources in the power system portfolio. In the empirical analysis performed on U.S. technical and cost data, we found that a non-volatile carbon tax scheme can produce significant effects on the power system portfolio selection problem in the presence of a carbon-free dispatchable source, like nuclear power, but it may have a negligible impact if the (non-renewable) dispatchable part of the power system portfolio is fully composed by fossil fuel, gas and coal, sources. On the other side, generating CO2 price volatility market-oriented mechanisms can produce relevant effects on both power system configurations. Although the empirical analysis is performed on U.S. data, the proposed methodology is general and can be used as a quantitative support by policy makers in their attempts to reconcile environmental and economic issues.