Miracle-dz/UniFAR-FTUs huggingface dataset:
Choline supplementation influences ovarian follicular development.

BACKGROUND Female infertility is a health issue for both humans and animals and despite developments in medical interventions, there are still some conditions that cannot be treated successfully. It is important to explore other potential therapies or remedies that could improve reproductive health. Choline is an over-the-counter supplement and essential nutrient that has many health benefits. It has been suggested to be beneficial in various aspects of fertility, including fetal development and endocrine disorders like polycystic ovarian syndrome (PCOS). However, choline's impact on ovarian function has not been explored. METHODS To study the effects of choline on ovarian development, 36 female Yorkshire × Landrace pigs were fed the following four supplemented diets between 90 and 186 days of age: (1) Control (corn and soybean meal-based diet that met estimated nutrient requirements, n = 9); (2) Choline (additional 500 mg choline per 1 kg of control diet, n = 8); (3) Omega-3 (additional 5556 mg Omega-3 per 1 kg control diet by introducing fish oil); (4) Choline + Omega-3 (500 mg choline + 5556 mg Omega-3 per 1 kg control diet). Pigs fed the choline-supplemented diet were compared to the control group and those fed diets supplemented with Omega-3 as fertility-promoting agent. RESULTS It was found that the number of corpus luteum per ovary in the Choline (16.25 ± 2.88), Omega-3 (10.78 ± 1.71) and Choline + Omega-3 (14.89 ± 2.97) groups were all higher in comparison to that of the control group (5.56 ± 1.72, p < 0.05). The percentage of antral follicles in the Choline + Omega-3 group were higher compared to the control group (p < 0.05). To elucidate the potential molecular mechanism of choline on these improved ovarian phenotypes, the expression of a group of genes that are involved in ovarian development, including cytochrome P450 family 11 subfamily A member 1 (CYP11A1), follicle stimulating hormone receptor (FHSR) and luteinizing hormone receptor (LHR), was analyzed using RT-qPCR. The expression of both LHR and CYP11A1 was significantly upregulated in the choline-supplemented group (p < 0.05), while there are no differences in FSHR expression among all the groups. Additionally, the expression of miR-21, -378, -574, previously found to be important in ovarian function, were examined. Our data showed that miR-574 was upregulated in the Choline group while miR-378 was upregulated in the Choline + Omega-3 group in comparison to the control group (p < 0.05). Further, serum metabolite analysis showed that 1-(5Z, 8Z, 11Z, 14Z, 17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine, a form of phosphatidylcholine metabolite, was significantly increased in all the treatment groups (p < 0.05), while testosterone was significantly increased in both Omega-3 and Choline + Omega-3 groups (p < 0.05) and tended to be reduced in the choline-supplemented group (p = 0.08) compared to the control group. CONCLUSIONS Our study demonstrated choline's influence on ovarian function in vivo, and offered insights into the mechanisms behind its positive effect on ovarian development phenotype.
LIST OF LAND SNAILS IN JAVA AND SEVERAL ADJACENT ISLANDS

The malacofauna of Java has been most studied among the Indonesian islands, but the list of land snails in the area remains outdated. This study presents an updated check list of land snails in Java and its adjacent islands. This list is a compilation data from field work in Java conducted in 2013-2016, records from various museums in Europe and Indonesia, collections from private collectors, data from citizen sciences, and literatures. In total, 263 land snail species were recorded in Java and its adjacent islands. The number comprises of 36 families i.e. Subclass Neritimorpha (2 families), Caenogastropoda (6 families), and Heterobranchia (28 families). About 40% are species endemic to Java and among them have restricted distribution to certain areas. In addition, 5% or 13 introduced species were recorded in Java.
Research on the Impact of Social Credit Improvement on the Debt Financing of Agricultural Enterprises

This study takes China’s A-shares agricultural companies as the research subjects and examines the influence of social credit environment on the debt financing of agricultural enterprises. This study has found that the improvement of social credit environment can significantly increase the debt financing scale of agricultural enterprises. After a placebo test, the replacement of explained variables, and the control of industry fixed effects, the results obtained are still significant. The mechanism test found that the scale of the enterprise has a complete intermediary effect; that is, the social credit environment can increase the scale of external financing of agricultural enterprises by increasing the scale of the enterprise. This article focuses on the impact of informal institutions on corporate debt financing, which is conducive to enriching relevant research on agricultural enterprises and has important practical significance for promoting the development of the agricultural industrial chain as well as “village revitalization. ”
The Influence of Grain Boundaries on Crystal Structure and Tensile Mechanical Properties of Al0.1CoCrFeNi High-Entropy Alloys Studied by Molecular Dynamics Method

The mechanical properties of high-entropy alloys are superior to those of traditional alloys. However, the key problem of finding a strengthening mechanism is still challenging. In this work, the molecular dynamics method is used to calculate the tensile properties of face-centered cubic Al0.1CoCrFeNi high-entropy alloys containing Σ3 grain boundaries and without grain boundary. The atomic model was established by the melting rapid cooling method, then stretched by the static drawing method. The common neighbor analysis and dislocation extraction algorithm are used to analyze the crystal evolution mechanism of Σ3 grain boundaries to improve the material properties of high-entropy alloys during the tensile test. The results show that compared with the mechanical properties Al0.1CoCrFeNi high-entropy alloys without grain boundary, the yield strength and Young’s modulus of a high-entropy alloy containing Σ3 grain boundary are obviously larger than that of high-entropy alloys without grain boundary. Dislocation type includes mainly 1/6<112> Shockley partial dislocations, a small account of 1/6<110> Stair-rod, 1/2<110>perfect dislocation, and 1/3<111> Hirth dislocations. The mechanical properties of high-entropy alloys are improved by dislocation entanglement and accumulation near the grain boundary.
A Conformal Regressor with Random Forests for Tropical Cyclone Intensity Estimation

Tropical cyclone intensity estimation is critical for disaster forecasting and severe weather warning. In recent years, the performance of various tropical cyclone intensity estimation models has been gradually enhanced, but the accuracy still needs to be improved. In this article, seventy-one intensity-related features are extracted from satellite infrared images of tropical cyclones. These features are grouped by eye features, circle features, texture features, and time-series features. Using the random forest model as the underlying algorithm of conformal prediction, an intensity applicable conformal prediction framework is proposed. On the one hand, the proposed network can achieve point estimation of the tropical cyclone intensity. On the other hand, it is also possible to realize the intensity interval estimation that satisfies a given significance level. In the experiments, the root mean square error of the point estimation algorithm is 7.86 kt (1 kt ≈ 0.51 m/s), and the performance of the proposed algorithm is better than the comparison algorithms. In addition, interval estimation enriches decision-making information. The experimental results show that the proposed model is a competitive and promising method for estimating the tropical cyclone intensity.
Effectiveness and safety of yoga to treat chronic and acute pain: a rapid review of systematic reviews

Background Pain is a sensation of discomfort that affects a large part of the population. Yoga is indicated to treat various health conditions, including chronic and acute pain. Objective To evaluate the effectiveness and safety of yoga to treat acute or chronic pain in the adult and elderly population. Study selection A rapid review was carried out, following a protocol established a priori. Searches were carried out in September 2019, in six databases, using PICOS and MeSH (Medical Subject Headings) and DeCS (Descritores em Ciências da Saúde) terms. Systematic reviews were included, and methodological quality was assessed using Assessing the Methodological Quality of Systematic Reviews. The results were presented in a narrative synthesis. Findings Ten systematic reviews were selected. Two reviews were assessed as of high methodological quality, two as of low quality, and six of critically low quality. Results were favourable to yoga compared with usual daily care, particularly in low back and cervical pain cases. There was little evidence about the superiority of yoga compared with active interventions (exercises, pilates or complementary and complementary medicine). It was also less consistent in pain associated with fibromyalgia, osteoarthritis, rheumatoid arthritis, carpal tunnel and irritable bowel syndromes. There was an improvement in the quality of life and mood of the participants, especially for yoga compared with usual care, exercises and waiting list. Conclusions Overall, the results were favourable to yoga compared with usual care in low back and cervical pain cases. The evidence is insufficient to assert yoga’s benefits for other pain conditions, as well as its superiority over active interventions. The findings must be considered with caution, given their low methodological quality and the small samples in the primary studies reported in the included systematic reviews. Thus, more studies must be carried out to improve the reliability of the results.
Local Variations in Carbohydrates and Matrix Lignin in Mechanically Graded Bamboo Culms

The mechanical performance of bamboo is highly dependent on its structural arrangement and the properties of biomacromolecules within the cell wall. The relationship between carbohydrates topochemistry and gradient micromechanics of multilayered fiber along the diametric direction was visualized by combined microscopic techniques. Along the radius of bamboo culms, the concentration of xylan within the fiber sheath increased, while that of cellulose and lignin decreased gradually. At cellular level, although the consecutive broad layer (Bl) of fiber revealed a relatively uniform cellulose orientation and concentration, the outer Bl with higher lignification level has higher elastic modulus (19.59–20.31 GPa) than that of the inner Bl close to the lumen area (17.07–19.99 GPa). Comparatively, the cell corner displayed the highest lignification level, while its hardness and modulus were lower than that of fiber Bl, indicating the cellulose skeleton is the prerequisite of cell wall mechanics. The obtained cytological information is helpful to understand the origin of the anisotropic mechanical properties of bamboo.
Near-Infrared Spectroscopy (NIRS) as a Method for Biological Sex Discrimination in the Endangered Houston Toad (Anaxyrus houstonensis)

Biological sex is one of the more critically important physiological parameters needed for managing threatened animal species because it is crucial for informing several of the management decisions surrounding conservation breeding programs. Near-infrared spectroscopy (NIRS) is a non-invasive technology that has been recently applied in the field of wildlife science to evaluate various aspects of animal physiology and may have potential as an in vivo technique for determining biological sex in live amphibian species. This study investigated whether NIRS could be used as a rapid and non-invasive method for discriminating biological sex in the endangered Houston toad (Anaxyrus houstonensis). NIR spectra (N = 396) were collected from live A. houstonensis individuals (N = 132), and distinct spectral patterns between males and females were identified using chemometrics. Linear discriminant analysis (PCA-LDA) classified the spectra from each biological sex with accuracy ≥ 98% in the calibration and internal validation datasets and 94% in the external validation process. Through the use of NIRS, we have determined that unique spectral signatures can be holistically captured in the skin of male and female anurans, bringing to light the possibility of further application of this technique for juveniles and sexually monomorphic species, whose sex designation is important for breeding-related decisions.
MILLIMETER WAVE SUBHARMONIC MIXER IMPLE- MENTATION USING GRAPHENE FILM COATING

In this work, a subharmonic frequency mixer for millimeter wave applications has been designed. The mixing and multiplication phenomena are simultaneously achieved via a nonlinear component consisting in a microstrip line gap covered by a graphene fllm coating. The circuit structure is made up of various fllters, which have been optimized to ensure high port-to-port isolation. The nonlinear behavior of the subharmonic frequency mixer has been experimentally evaluated within the 39{40.5GHz RF frequency band. The frequency downconversion is achieved by mixing the RF signal with the second harmonic component of a 17.9GHz LO signal. Conversion losses are minimized by generating a return path for IF, through the use of a quarter wavelength open-ended stub.
Not Drug-like, but Like Drugs: Cnidaria Natural Products

Phylum Cnidaria has been an excellent source of natural products, with thousands of metabolites identified. Many of these have not been screened in bioassays. The aim of this study was to explore the potential of 5600 Cnidaria natural products (after excluding those known to derive from microbial symbionts), using a systematic approach based on chemical space, drug-likeness, predicted toxicity, and virtual screens. Previous drug-likeness measures: the rule-of-five, quantitative estimate of drug-likeness (QED), and relative drug likelihoods (RDL) are based on a relatively small number of molecular properties. We augmented this approach using reference drug and toxin data sets defined for 51 predicted molecular properties. Cnidaria natural products overlap with drugs and toxins in this chemical space, although a multivariate test suggests that there are some differences between the groups. In terms of the established drug-likeness measures, Cnidaria natural products have generally lower QED and RDL scores than drugs, with a higher prevalence of metabolites that exceed at least one rule-of-five threshold. An index of drug-likeness that includes predicted toxicity (ADMET-score), however, found that Cnidaria natural products were more favourable than drugs. A measure of the distance of individual Cnidaria natural products to the centre of the drug distribution in multivariate chemical space was related to RDL, ADMET-score, and the number of rule-of-five exceptions. This multivariate similarity measure was negatively correlated with the QED score for the same metabolite, suggesting that the different approaches capture different aspects of the drug-likeness of individual metabolites. The contrasting of different drug similarity measures can help summarise the range of drug potential in the Cnidaria natural product data set. The most favourable metabolites were around 210–265 Da, quite often sesquiterpenes, with a moderate degree of complexity. Virtual screening against cancer-relevant targets found wide evidence of affinities, with Glide scores <−7 in 19% of the Cnidaria natural products.
A framework for assessing information system (IS)security practices in Libraries.

Security of information systems is vital in any library regardless of its type and size. If the critical library’s resources such as online catalogs, online databases and websites are interrupted and unavailable to its end users, the impact might affect the library’s mission as an information provider thus impeding the library and its end users’ performance. In order to protect the information systems, many libraries have implemented necessary security control. This paper gives an overview of a suggested framework for assessing information systems security practices in libraries. A brief description of the framework and a more detailed overview on the five steps to be evaluated in the framework are highlighted. An implementation index as well as a scoring tool that may be used to assist the assessment of information systems safeguarding measures in a library are also presented.
Evaluating the technique of using MDI and DPI in patients with respiratory disease

Inhalation therapy plays a major role in treatment of respiratory diseases. Correct inhalation technique is crucial for effective clinical outcomes. The aim of this study was to evaluate and analyse technique of use of Metered Dose Inhaler (MDI) and Dry Powder Inhaler (DPI) in patients with respiratory disease. This observational study was conducted at pulmonary outpatient department of a tertiary care hospital. 30 patients were enrolled using convenience sampling. Participants’ demographic and disease specific data was recorded. Participants were asked to use their inhaler just as they would at home. The technique of device use was observed and recorded using inhaler specific checklists. Data collected was analyzed using descriptive statistics. Out of 30 patients 26 were using MDI, 23 of which (92%) performed at least 1 error. Among 4 patients using DPI, 3 (75%) performed at least 1 error. Patients using MDI for more than 1 year performed less errors compared to those who had been using MDI for less than 1 year, however the difference observed was not significant (n=26, p= 0.304). 29 patients (96%) received education about inhaler device use. The most common incorrectly performed steps were “complete exhalation” and “breath hold. ” 92% of MDI and 75% of DPI users made at least one error during the inhalation maneuver despite majority being educated about inhaler technique. The most frequently performed incorrect steps for MDI and DPI were “Complete exhalation” and “Breath hold”.
The impact of web site design on consumer loyalty in business-to-consumer (b2c) internet commerce: a rhetorical approach

With an enormous multitude of consumers globally, the Internet offers an opportunity that merchants have never before seen. However, electronic commerce has experienced the meteoric rise and subsequent crash of any behemoth entity cast aloft without moorings or foundation. An important issue related to Internet commerce is what factors would facilitate customer loyalty to a Web site. An effective Web site design could be one of the ways to a company success. Using the previously unapplied concepts of logos, pathos, and ethos to electronic commerce as found in the research taxonomy of Winn and Beck's studies (2002), this research composes a theoretical framework for further investigate the interaction between the customer and the Web site design in Business-to-Consumer (B2C) Internet commerce. The research design employed a quantitative method approach using 36 closed-ended questions, plus one open-ended question on the survey instrument. A survey questionnaire with a closed-ended 1 to 9 Likert scale was used to ask respondents the extent to which they disagree or agree (1 = very strongly disagree, 5 = neither agree nor disagree, 9 = very strongly agree). Data was collected in a period of four months from September to December of 2003. A sample using a Web survey in U.S. was obtained with an “N” count of 307. Collected data were analyzed by SPSS Windows Version 11.0. A total of five different statistical analyses were employed in this study. They are descriptive statistics, correlation analysis, independent-samples t Test analysis, one-way ANOVA analysis, and multiple regression analysis. Rhetorical design is concerned with modification of the consumer's attitude toward the site. Results of this study indicated that the more rhetorical elements that online sellers can offer through the visual display of Web sites, the more interested the consumers will be to frequently visit, make repeated purchases, and do “word-of-mouth” referrals to the same Web site. The outcomes of this study will help marketers and Web designers to create the most persuasive site environment for online shoppers. Web sites that operate on the basis of rational, emotional, and credible ways will have best chances to win customers loyalty.
Análise de Estratégias de Controle de Erros para Redes de Sensores com Modulação OQPSK e GFSK

This paper proposes an analytical model to evaluate the packet error rate and the energy efficiency of different error control schemes in wireless sensor networks. Retransmission strategies, channel coding and hybrid FEC/ARQ schemes for OQPSK and GFSK modulations are studied. The wireless channel is modeled with Rayleigh fading. The obtained results may indicate the modulation type and error control technique to be used in a network with different number of hops and signal-to-noise ratio values. Index terms – modulation, error control, sensor networks, energy efficiency.
Adoption of opioid-prescribing guidelines in primary care: a realist synthesis of contextual factors

Objective As part of an effort to design an implementation strategy tailoring tool, our research group sought to understand what is known about how contextual factors and prescriber characteristics affect the adoption of guideline-concordant opioid-prescribing practices in primary care settings. Design We conducted a realist synthesis of 71 articles. Results We found that adoption is related to contextual factors at the individual, clinic, health system and environmental levels, which operate via intrapersonal, interpersonal, organisational and structural mechanisms. Conclusion A single static model cannot capture the complexity of the relationships between contexts, mechanisms and outcomes. Instead, a deeper understanding requires a dynamic model that conceptualises clusters of contextual factors and mechanisms that tend towards guideline concordance and clusters that tend toward non-concordance. Trail registration number ClinicalTrial.gov registration number NCT04044521.
Application of the Supercapacitor for Energy Storage in China: Role and Strategy

Supercapacitors are widely used in China due to their high energy storage efficiency, long cycle life, high power density and low maintenance cost. This review compares the differences of different types of supercapacitors and the developing trend of electrochemical hybrid energy storage technology. It gives an overview of the application status of supercapacitors in China’s smart grid and Energy Internet in detail. Some strategies and constructive suggestions are put forward to solve the existing problems. With the improvement of the grid-connected capacity of new energy power generation during the 14th Five-year Period of China, the supercapacitor market in China will usher in a good development opportunity. The role of the supercapacitor in achieving carbon peak carbon neutralization is prospected.
OUTILS ET PROCÉDURES DE CARACTÉRISATION DES SOLS INDURÉS ET DES ROCHES TENDRES : L'EXPÉRIENCE DU LRPC D'AIX EN PROVENCE TOOLS AND PROCEDURES FOR CHARACTERISING INDURATED SOILS AND SOFT ROCKS: EXPERIENCE GAINED AT AIX-EN-PROVENCE LRPC

Various types of equipment are used at Aix-en-Provence Regional Laboratory (LRPC) to study the behaviour of marls in their natural state and measure their mechanical properties. These devices and the principles of the test procedures are presented in the paper, in the light of test results which illustrate various aspects of the behaviour of natural marls and the present state of knowledge of this family of indurated soils and soft rocks.