Miracle-dz/UniFAR-FTUs huggingface dataset:
The research team of the CoV2Soul.RS project, reports the preliminary results on depressiveness in Serbia, on the occasion of the world mental health day

Nacionalno istraživanje psihijatrijskih smetnji u vreme pandemije KOVID-19 infekcije u našoj zemlji (akronim Cov2Soul.RS; finansirano od strane Fonda za nauku Republike Srbije – www.cov2soul.rs), u koje su uključeni istraživači sa Univerziteta u Beogradu i Novom Sadu, do sada je prikupilo preko 80,0% materijala neophodnog za konačne analize. Ukupno pedeset dvoje obučenih saradnika (lekari, psiholozi, apsolventi medicine) obavili su preko 1.000 dubinskih kliničkih intervjua, obilazeći celu Srbiju, da bi se postigla reprezentativnost uzorka. Pored obavljanja kliničkih intervjua, prikupljani su i drugi podaci o jačini kovid stres sindroma u našoj populaciji, o zdravlju uopšte, o upotrebi lekova za smirenje, o usamljenosti, o uverenjima oko nastanka i širenja pandemije, o dobrim i lošim stranama aktuelne situacije, o kvalitetu života, o strukturi ličnosti (više o protokolu istraživanja videti u referenci 1, u spisku literature na kraju rada). Konačne rezultate, koji će po prvi put pokazati učestalost psihijatrijskih poremećaja prema MeđunarodDear Editors,
Motor-Level N-MPC for Cooperative Active Perception With Multiple Heterogeneous UAVs

This letter introduces a cooperative control framework based on Nonlinear Model Predictive Control (NMPC) for solving an Active Information Acquisition problem (AIA) using a system of multiple multirotor UAVs equipped with onboard sensors. The observation task of the NMPC is a minimum-uncertainty pose estimation of a moving feature which is observed by the multi-UAV system, using a cooperative Kalman filter. The controller considers a full nonlinear model of the multirotors – including the motor-level actuation units and their real constraints in terms of maximum torque – and embeds the Kalman filter estimation uncertainty in its prediction. The framework allows and exploits heterogeneity in the actuation and sensing systems by considering a generic model of UAV – including both quadrotors and tilted-propeller multirotors – and a generic model of range-and-bearing sensor with arbitrary rate and field of view. The capability of the proposed framework to reduce the cooperative estimation uncertainty of a static or a moving feature, thus leading the system to optimal sensing configurations, is demonstrated through Gazebo simulations and real experiments. The software is provided open-source.
Electric Vehicle Charging Station Planning Based on Computational Geometry Method

This paper comprehensively analyzes several factors that influence the charging station planning for electric vehicles,and then an income optimization model of charging station planning for electric vehicles is developed.In order to meet the capacity requirement of charging station in the planning area,the electric vehicles' expected power demand is calculated based on the charging characteristics and trip characteristics of electric vehicles.The weights of Voronoi diagram are adjusted to make the service areas divided more rationally and the load rate better balanced based on the distribution characteristic of electric vehicles.Combining the weighted Voronoi diagram,the global searching ability of the particle swarm optimization algorithm is used to locate and size the charging stations and optimally plan the service areas.By calculating different numbers of electric vehicles and different ways of distribution,the results verify the effectiveness and feasibility of the proposed model and algorithm.
Effect of Non-surgical Periodontal Therapy on Levels of Inflammatory Markers in Gingival Crevicular Fluid and Serum of Patients With Breast Cancer and Periodontitis.

Purpose: studies have demonstrated the positive impact of non-surgical periodontal therapy (NSPT) on the control of local and systemic infection/inflammation in normosystemic and systemically compromised patients, represented by the improvement of periodontal clinical parameters and reduction in the levels of inflammatory markers in the gingival crevicular fluid (GCF), saliva and serum. This study aimed to evaluate periodontal clinical parameters and inflammatory mediators in GCF and serum, before and after NSPT, in patients with periodontitis and breast cancer, before chemotherapy. Methods: seventeen women with histopathological diagnosis of invasive ductal carcinoma and periodontitis were submitted to the evaluation of clinical periodontal parameters (plaque index – PI, bleeding on probing – BOP, probing depth – PD, clinical attachment level – CAL) and submitted to scaling and root planing (SRP), at an interval of 24 hours. At the beginning of the study (baseline), before NSPT, samples of tumor microenvironment fluid (TM), GCF and peripheral blood (serum) were collected for the determination of inflammatory markers IL-1β, TNF-α, TGF-β and IL-17, using the LUMINEX methodology. Seven days after SRP, new GCF and serum samples were obtained and analyzed.Results: TGF-β levels were significantly decreased in GCF and serum (p<0.05), while IL-17 concentrations were statistically reduced in GCF (p<0.05). Conclusion: NSPT decreased local and systemic inflammatory markers and may be an important tool in the multidisciplinary approach of women with breast cancer and periodontitis before chemotherapy.
Research of Stress Survey by Fiber Bragg Grating

One kind of temperature compensation fiber grating stress sensor is proposed.FBG is stuck on a special-structured cantilever.Through the theory deducing,the distance of center wavelengths of two reflecting peaks is relative not to temperature change but load variety as linearity.In the experiment,two reflecting peaks appear as weights are 70 g.When weights are added to 180 g,the distance of two center wavelengths is 0.15 nm.Carries on the data fitting to the experimental findings,and the linearity is up to 0.97,which indicates the feasibility and validity of this method.
Grid-Connected Inverter in Direct-Drive Wind Power Generation System

The detailed mathematical model of grid-connected inverter is derived. To suppress harmonics in output current of the inverter,the technology of space vector pulse width modulation is adopted. According to the mathematical model grid-connected inverter in synchronously rotating coordinate system and by use of vector control oriented by power system voltage vector and d-and q-axis current close-loop control,the d-and q-axis current decoupling control is implemented in which the d-axis current controls active power and the q-axis current control reactive power. Simulation and experiment results verify that the proposed control scheme is feasible and correct.
Real-time diagnostic accuracy of blue light imaging, linked color imaging and white-light endoscopy for colorectal polyp characterization

Background and study aims Fujifilm has developed a novel ELUXEO 7000 endoscope system that employs light-emitting diodes (LEDs) at four different wavelengths as light sources that enable blue light imaging (BLI), linked color imaging (LCI), and high-definition white-light endoscopy (HD-WLE). The aim of this study was to address the diagnostic accuracy of real-time polyp characterization using BLI, LCI and HD-WLE (ELUXEO 7000 endoscopy system). Patients methods This is a prespecified post-hoc analysis of a prospective study in which 22 experienced endoscopists (> 2,000 colonoscopies) from eight international centers participated. Using a combination of BLI, LCI, and HD-WLE, lesions were endoscopically characterized including a high- or low-confidence statement. Per protocol, digital images were created from all three imaging modalities. Histopathology was the reference standard. Endoscopists were familiar with polyp characterization, but did not take dedicated training for purposes of this study. Results Overall, 341 lesions were detected in 332 patients. Of the lesions, 269 histologically confirmed polyps with an optical diagnosis were included for analysis (165 adenomas, 27 sessile serrated lesions, and 77 hyperplastic polyps). Overall, polyp characterization was performed with high confidence in 82.9 %. The overall accuracy for polyp characterization was 75.1 % (95 % confidence interval [CI] 69.5–80.1 %), compared with an accuracy of 78.0 % (95 % CI 72.0–83.2 %) for high confidence assignments. The accuracy for endoscopic characterization for diminutive polyps was 74.7 % (95 %CI 68.4–80.3 %), compared with an accuracy of 78.2 % (95 % CI 71.4–84.0 %) for high-confidence assignments. Conclusions The diagnostic accuracy of BLI, LCI, and HD-WLE by experienced endoscopist for real-time polyp characterization seems limited (NCT03344289).
Inducible co-stimulator inhibits lipid phagocytosis of human aortic smooth muscle cells by down-regulating CD36 expression

Background To explore the potential mechanism of inducible co-stimulator (ICOS) inhibition of lipid phagocytosis in human aortic smooth muscle cells (HASMCs). Methods Excess Dil (1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate)-labeled oxidized low-density lipoprotein (ox-LDL) was used to induce HASMCs to form a foam cell model; HASMCs were cultured together with ICOS-overexpressed JurKat (JK-ICOS) cells or recombinant human ICOS protein (rICOS protein) to be stimulated, and a confocal laser microscope was used to observe the lipid phagocytosis of HASMCs. Reverse transcription quantitative polymerase chain reaction (RT-qPCR), western blot, and immunofluorescence staining were used to detect the expression of the lipid phagocytic receptor, cluster of differentiation 36 (CD36) in HASMCs. Results The uptake of Dil ox-LDL by HASMCs was concentration-dependent, and excessive Dil ox-LDL uptake led to lipid accumulation in HASMCs. Pretreatment with JK-ICOS cells or rICOS protein for HASMCs 48 hours reduced Dil ox-LDL-induced lipid accumulation. Compared with HASMCs co-cultured with empty lentiviral JurKat (JK-EV) cells, the messenger RNA (mRNA) and protein expressions of CD36 in HASMCs co-cultured with JK-ICOS cells were significantly down-regulated. The results of immunofluorescence staining showed that co-culturing with JK-ICOS cells could down-regulate ox-LDL-induced expression of CD36 in HASMCs, but JK-EV cells could not. Similarly, the results of qPCR, western blot, and immunofluorescence staining showed that rICOS protein could down-regulate the ox-LDL-induced expression of CD36 in HASMCs, but this down-regulation was not as significant as that in JK-ICOS cells. Conclusions ICOS could inhibit the lipid phagocytosis of HASMCs by down-regulating the expression of CD36, suggesting a potential anti-atherosclerosis (anti-AS) mechanism of ICOS, and preventing ox-LDL-induced formation of myogenic foam cells.
Hypoxemia associated with lumbar puncture in neonates

Objectives: The objectives of the study were to study the effect of different stages of lumber puncture (LP) procedure on oxygen saturation (SpO2) in newborn baby. Materials and Methods: It was a 1-year, prospective observational study conducted in a tertiary care hospital. Forty neonates were included who fulfilled the inclusion criteria. SpO2 was measured during the different stages of LP in the recruited newborns and comparison was done between SpO2 changes in LP duration of <5 min and more than 5 min groups and the effect on SpO2 in preterm and term babies during LP. Results: Mean SpO2 during baseline, flexion, needle insertion, immediate repositioning, and 5 min after procedure were 94.5, 91.82, 88.92, 94.7, and 95.38, respectively. When compare to baseline, drop in SpO2 was found during flexion and needle insertion with p = 0.0025 and <0.0001, respectively. While comparing Mean SpO2 during different phases between duration of LP >5 min versus <5 min group, the saturation was less during flexion positioning with maximum fall at the time of needle insertion in LP duration >5 min. The regain of saturation during repositioning was more in LP <5 min versus duration >5 min group. Comparing between LP duration >5 min versus <5 min group, fall in SpO2 from baseline (5 min before LP procedure) was more in LP duration >5 min group during flexion and needle insertion phase. Hypoxemia is more in preterm than term neonates during flexion and during needle insertion, supine repositioning. Furthermore, hypoxia recovered after 5 min of supine repositioning more in term infants. Conclusions: Significant hypoxia was associated in newborn in flexion and needle insertion phase of lumbar puncture, especially in preterm newborns and those with prolonged duration of procedure.
Transposable elements contribute to the spatiotemporal microRNA landscape in human brain development

Transposable elements (TEs) contribute to the evolution of gene regulatory networks and are dynamically expressed throughout human brain development and disease. One gene regulatory mechanism influenced by TEs is the miRNA system of post-transcriptional control. miRNA sequences frequently overlap TE loci and this miRNA expression landscape is crucial for control of gene expression in adult brain and different cellular contexts. Despite this, a thorough investigation of the spatiotemporal expression of TE-embedded miRNAs in human brain development is lacking. Here, we identify a spatiotemporally dynamic TE-embedded miRNA expression landscape between childhood and adolescent stages of human brain development. These miRNAs sometimes arise from two apposed TEs of the same subfamily, such as for L2 or MIR elements, but in the majority of cases stem from solo TEs. They give rise to in silico predicted high-confidence pre-miRNA hairpin structures, likely represent functional miRNAs and have predicted genic targets associated with neurogenesis. TE-embedded miRNA expression is distinct in the cerebellum when compared to other brain regions, as has previously been described for gene and TE expression. Furthermore, we detect expression of previously non-annotated TE-embedded miRNAs throughout human brain development, suggestive of a previously undetected miRNA control network. Together, as with non-TE-embedded miRNAs, TE-embedded sequences give rise to spatiotemporally dynamic miRNA expression networks, the implications of which for human brain development constitute extensive avenues of future experimental research. To facilitate interactive exploration of these spatiotemporal miRNA expression dynamics, we provide the “Brain miRTExplorer” web application freely accessible for the community.
Systemic Profile of Cytokines in Arteriovenous Fistula Patients and Their Associations with Maturation Failure

Key Points Seven of 74 cytokines profiled were elevated in patients with AVF maturation failure compared with participants with successful maturation. G-CSF, MDC, RANTES, SDF-1, and TGFα demonstrated significant incremental associations with AVF maturation failure by logistic regression. This investigation may open the doors for future therapeutics and markers for risk stratification. Visual Abstract Background Systemic cytokines are elevated in patients with chronic kidney disease (CKD) and on hemodialysis compared with the general population. However, whether cytokine levels interfere with vascular remodeling, increasing the risk of arteriovenous fistula (AVF) failure, remains unknown. Methods This is a case-control study of 64 patients who underwent surgery for AVF creation (32 with AVF maturation failure and 32 matching controls with successful maturation). A total of 74 cytokines, including chemokines, interferons, interleukins, and growth factors, were measured in preoperative plasma samples using multiplex assays. Sixty-two patients were included in the statistical analyses. Associations with AVF failure were assessed using paired comparisons and conditional logistic regressions accounting for paired strata. Results Seven cytokines were significantly higher in patients with AVF maturation failure than in matching controls (G-CSF, IL-6, MDC, RANTES, SDF-1α/β, TGFα, and TPO). Of these, G-CSF (odds ratio [OR]=1.71; 95% confidence interval [95% CI], 1.05 to 2.79 per 10 pg/ml), MDC (OR=1.60, 95% CI, 1.08 to 2.38 per 100 pg/ml), RANTES (OR=1.55, 95% CI, 1.10 to 2.17 per 100 pg/ml), SDF-1α/β (OR=1.18, 95% CI, 1.04 to 1.33 per 1000 pg/ml), and TGFα (OR=1.39, 95% CI 1.003, 1.92 per 1 pg/ml) showed an incremental association by logistic regression. Conclusions This study identified a profile of plasma cytokines associated with adverse maturation outcomes in AVFs. These findings may open the doors for future therapeutics and markers for risk stratification.
Intelligent System for Estimation of the Spatial Position of Apples Based on YOLOv3 and Real Sense Depth Camera D415

Despite the great possibilities of modern neural network architectures concerning the problems of object detection and recognition, the output of such models is the local (pixel) coordinates of objects bounding boxes in the image and their predicted classes. However, in several practical tasks, it is necessary to obtain more complete information about the object from the image. In particular, for robotic apple picking, it is necessary to clearly understand where and how much to move the grabber. To determine the real position of the apple relative to the source of image registration, it is proposed to use the Intel Real Sense depth camera and aggregate information from its depth and brightness channels. The apples detection is carried out using the YOLOv3 architecture; then, based on the distance to the object and its localization in the image, the relative distances are calculated for all coordinates. In this case, to determine the coordinates of apples, a transition to a symmetric coordinate system takes place by means of simple linear transformations. Estimating the position in a symmetric coordinate system allows estimating not only the magnitude of the shift but also the location of the object relative to the camera. The proposed approach makes it possible to obtain position estimates with high accuracy. The approximate root mean square error is 7–12 mm, depending on the range and axis. As for precision and recall metrics, the first is 100% and the second is 90%.
4.5 - Die Pulveraerosoldepositionsmethode - ein neues Verfahren zur Herstellung dichter Sensorschichten bei Raumtemperatur

Mit der Pulveraerosoldepositionsmethode (PAD) lassen sich dichte keramische Schichten ohne Hochtemperaturprozess direkt aus dem Ausgangspulver auf fast beliebige Substratmaterialien aufbringen. Dazu wird ein Pulveraerosol erzeugt und in ein Prozessgas geleitet. Das Aerosol wird durch eine Druckdifferenz vom Aerosolerzeuger in eine Vakuumkammer befördert, wo es durch eine Düse auf etwa Schallgeschwindigkeit beschleunigt und auf ein zu beschichtendes Substrat gelenkt wird (Abb. 1). Dabei können fest anhaftende Schichten von etwa 1 μm bis ca. 100 μm Dicke erzeugt werden. Die Funktionseigenschaften der erzeugten Schicht entsprechen in etwa denen des Ausgangsmaterials. Der Schichtbildungsmechanismus ist allerdings noch nicht völlig verstanden. Es wird angenommen, dass durch die große kinetische Energie die submikrometergroßen Partikel beim Aufprall auf das Substrat in nanometergroße Bruchstücke zerbrechen. Zunächst bildet sich eine Ankerschicht auf dem Substrat aus, danach kommt es zu einem kontinuierlichen Schichtaufbau bei gleichzeitiger Verdichtung („Hammering“) [1-3].
Climate Change and Zoonoses: A Review of Concepts, Definitions, and Bibliometrics

Climate change can have a complex impact that also influences human and animal health. For example, climate change alters the conditions for pathogens and vectors of zoonotic diseases. Signs of this are the increasing spread of the West Nile and Usutu viruses and the establishment of new vector species, such as specific mosquito and tick species, in Europe and other parts of the world. With these changes come new challenges for maintaining human and animal health. This paper reports on an analysis of the literature focused on a bibliometric analysis of the Scopus database and VOSviewer software for creating visualization maps which identifies the zoonotic health risks for humans and animals caused by climate change. The sources retained for the analysis totaled 428 and different thresholds (N) were established for each item varying from N 5 to 10. The main findings are as follows: First, published documents increased in 2009–2015 peaking in 2020. Second, the primary sources have changed since 2018, partly attributable to the increase in human health concerns due to human-to-human transmission. Third, the USA, the UK, Canada, Australia, Italy, and Germany perform most zoonosis research. For instance, sixty documents and only 17 countries analyzed for co-authorship analysis met the threshold led by the USA; the top four author keywords were “climate change”, “zoonosis”, “epidemiology”, and “one health;” the USA, the UK, Germany, and Spain led the link strength (inter-collaboration); the author keywords showed that 37 out of the 1023 keywords met the threshold, and the authors’ keyword’s largest node of the bibliometric map contains the following: infectious diseases, emerging diseases, disease ecology, one health, surveillance, transmission, and wildlife. Finally, zoonotic diseases, which were documented in the literature in the past, have evolved, especially during the years 2010–2015, as evidenced by the sharp augmentation of publications addressing ad-hoc events and peaking in 2020 with the COVID-19 outbreak.
SARS-Cov-2 Infection in Postmenopausal Women. New Data on Menopause Hormone Therapy

ObjectiveTo address the factors involved in hospital admission and medical follow up in postmenopausal women with COVID-19 diagnosis.MethodsRetrospective observational study. Postmenopausal women aged between 40-70 years since September 2020 until June 2021 with COVID-19 diagnosis were included. Of the 300 women cohort, 50 were receiving menopause hormone therapy (MHT)Results 288 patients were analyzed. The mean age was 56.20 years (+/-6.06y SD). Age (p=0.030), High blood pressure (HBP) (p=0.002), respiratory disorders (p=0.003), depression (p=0.028) and fibromyalgia (p=0.030) were associated with a greater risk for hospital admission, while MHT was found as a protective factor (p=0.042). Being a health professional (p<0.001), HBP (p=0.029), respiratory disorders (p=0.022), vitamin D deficiency (p=0.010), depression (p=0.005) and fibromyalgia (p=0.001) were related with a longer follow up while MHT was related with a shorter one (p=0.010). Regression analysis showed that HBP and respiratory disorders acted as independent factors for hospital admission while MHT and fibromyalgia were for the length of follow up. ConclusionsMHT has a positive impact in postmenopausal women with SARS-CoV-2 infection. HBP and respiratory disorders are associated with a higher risk of hospital admission of these patients.
Ion-doped mesoporous bioactive glass: preparation, characterization, and applications using the spray pyrolysis method

Biotechnology is used extensively in medical procedures, dentistry, statures, biosensors, bio electrodes, skin substitutes, and medicine delivery systems. Glass is biocompatible and can be used in permanent implantation applications without risk. The porosity of BG matrixes, combined with their huge specific surface area, greatly aids the formation of hydroxyl carbonate apatite. Zn-Doped bioglass can be made in the lab in a variety of ways, depending on how it will be used in medical treatment. The melt-quenching technique, spray pyrolysis method, sol–gel process for BG fabrication, spray drying method, and modified Stöber method are examples of such strategies. Spray pyrolysis is a comprehensive approach that is an undeniably versatile and effective material synthesis technology. It is a low-cost, non-vacuum method for producing materials in the form of powders and films that may be deposited on a variety of substrates, and is a straightforward method to adapt for large-area deposition and industrial production processes. For better utility in medical care, MBG fabricated in the laboratory should be characterized using various characterization methods such as SEM, TEM, BET, and XRD.