Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative Experimental Research on Haptic Display Methods of Virtual Surface Shape Based on Touch Screen

With the wide application of touch screen technology in daily life, more and more studies have tried to use touch screen as a carrier to convey the surface shape features of virtual objects to people. Current studies have proposed methods such as direct height mapping and haptic illusion based on lateral force to display the geometric shape of virtual surfaces on the touch screen. However, whether there are differences in the performance of these methods in displaying the shape features, and whether the lateral force-based haptic illusion can be used to display the shape features of complex surfaces, has not been fully explored. Aiming at this situation, in this article, we carry out user experiments on two regular shapes and eight natural images under displacement field and two types of lateral force fields with the help of three haptic devices previously designed. We also evaluate the effect of image smoothing on users' perception of natural image shape features. Experimental results show that the current shape display devices and methods that can simulate the lateral force field proposed by (Minsky et al., 1990) cannot achieve the display effect of the displacement field on complex shapes, and the shape display effect is the worst when only resistive lateral force feedback is employed. Nevertheless, since methods based on lateral force field, such as electrovibration, allow people to directly perceive the shape features of the virtual surface on the touch screen with their bare fingers, continuous research on this shape expression method still has a very attractive prospect.
Potential origins of fish toti-like viruses in invertebrates.

The virus family Totiviridae had originally been considered to include only viruses which infected fungal and protist hosts, but since 2006 a growing number of viruses found in invertebrates and fish have been shown to cluster phylogenetically within this family. These Totiviridae-like, or toti-like, viruses do not appear to belong within any existing genera of Totiviridae, and whilst a number of new genus names have been suggested, none has yet been universally accepted. Within this growing number of toti-like viruses from animal hosts, there exists emerging viral threats particularly to aquaculture, namely Infectious myonecrosis virus in whiteleg shrimp and Piscine myocarditis virus (PMCV) in Atlantic salmon (Salmo salar). PMCV in particular continues to be an issue in salmon aquaculture as a number of questions remain unanswered about how the virus is transmitted and the route of entry into host fish. Using a phylogenetic approach, this study shows how PMCV and the other fish toti-like viruses probably have deeper origins in an arthropod host. Based on this, it is hypothesized that sea lice could be acting as a vector for PMCV, as seen with other RNA viruses in Atlantic salmon aquaculture and in the toti-like Cucurbit yellows-associated virus which is spread by the greenhouse whitefly Trialeurodes vaporariorum.
The COVID‐19 pandemic and youth with anorexia nervosa: A retrospective comparative cohort design

Abstract Objective There is a growing body of literature suggesting the novel coronavirus pandemic (COVID‐19) negatively impacts mental health in individuals self‐reporting an eating disorder (ED); however, limited pediatric data is available about the impact COVID‐19 has had on youth with EDs, specifically Anorexia Nervosa (AN). Our study uses a cross‐sectional design to explore differences in ED symptoms between adolescents diagnosed with AN during the COVID‐19 pandemic compared to a retrospective cohort of adolescents for whom these measures were previously collected, prior to the pandemic. Method We report cross‐sectional data assessing differences between AN behaviors and cognitions during the COVID‐19 pandemic compared to a retrospective cohort (n = 25 per cohort) assessed before the pandemic. Results Results suggest that individuals with a first‐time diagnosis of AN during the pandemic had lower percent expected body weight, and more compulsive exercise behaviors. Conclusions These data support existing pediatric findings in exercise and body weight differences in adolescents with AN before and during the pandemic. Findings may be helpful in informing considerations for providers treating ED patients amidst and after the pandemic. Public Significance This manuscript compares a retrospective cohort of adolescents diagnosed with AN prior to the pandemic to a cohort of adolescents diagnosed with AN during the pandemic. Results report that adolescents diagnosed with AN during the pandemic have lower weights and increased compensatory exercise behavior compared to adolescents diagnosed with AN before the pandemic despite no difference in length of illness. Findings may be helpful in informing considerations for providers treating ED patients amidst and after the pandemic.
Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology–ASCO Guideline

PURPOSE The aim of this joint guideline is to provide evidence-based recommendations to practicing physicians and other health care providers on integrative approaches to managing pain in patients with cancer. METHODS The Society for Integrative Oncology and ASCO convened an expert panel of integrative oncology, medical oncology, radiation oncology, surgical oncology, palliative oncology, social sciences, mind-body medicine, nursing, and patient advocacy representatives. The literature search included systematic reviews, meta-analyses, and randomized controlled trials published from 1990 through 2021. Outcomes of interest included pain intensity, symptom relief, and adverse events. Expert panel members used this evidence and informal consensus to develop evidence-based guideline recommendations. RESULTS The literature search identified 227 relevant studies to inform the evidence base for this guideline. RECOMMENDATIONS Among adult patients, acupuncture should be recommended for aromatase inhibitor–related joint pain. Acupuncture or reflexology or acupressure may be recommended for general cancer pain or musculoskeletal pain. Hypnosis may be recommended to patients who experience procedural pain. Massage may be recommended to patients experiencing pain during palliative or hospice care. These recommendations are based on an intermediate level of evidence, benefit outweighing risk, and with moderate strength of recommendation. The quality of evidence for other mind-body interventions or natural products for pain is either low or inconclusive. There is insufficient or inconclusive evidence to make recommendations for pediatric patients. More research is needed to better characterize the role of integrative medicine interventions in the care of patients with cancer. Additional information is available at https://integrativeonc.org/practice-guidelines/guidelines and www.asco. org/survivorship-guidelines.
Effect of strain on thresholdless Auger recombination in quantum wells

Effect of strain on thresholdless Auger recombination processes in quantum wells has been studied theoretically. A detailed analysis of overlap integrals between the initial and final states of the particles has been carried out. It is shown that the strain both qualitatively and quantitatively affects the overlap integral between the electron and hole states. It is demonstrated that the Auger recombination rate decreases as compressive strain increases.
Non-Equilibrium Molecular Dynamics Simulations: Techniques and Applications

These lectures notes are devoted to the presentation of properties of matter in non-equilibrium conditions by using the techniques of Non-Equilibrium Molecular Dynamics. As a first application, results on the simulation of shock waves in solids are presented. Shock propagation can be modeled by a direct Molecular Dynamics simulation. The shocked state is compared to a modeling through a dynamics constrained by the Hugoniot relations with a uniaxial compression: this new technique, named Hugoniotstat, allows to compute directly the shocked state properties without having to make a full study of the shock. The next application is concerned with properties of granular fluids. Those systems are always in a nonequilibrium state with energy flowing from an external forcing towards the internal elastic energy of the grains. Constant-energy simulation of inelastic hard disks are performed by a rescaling of the velocities at every dissipative collisions, a method we call Sotostat. This technique is used to compare.
Student perceptions of the current drinking culture in three Australian residential colleges: Drinking motives, consequences and recommendations for harm minimisation strategies

Abstract Introduction Systemic cultural factors related to excessive alcohol consumption have been identified in Australian university residential colleges. In this mixed methods study, we conducted focus groups with student leaders at three Australian residential colleges. We aimed to explore students' perceptions of alcohol use and related consequences in their current college environment and gather feedback from students on the utility of alcohol harm minimisation strategies in this context. Methods In November 2020, 77 student leaders from three colleges participated in focus groups. Each focus group ran for 1.5–2 hours and included three sections: (i) quantitative survey; (ii) semi‐structured group interview; and (iii) feedback on a potential alcohol harm minimisation workshop. Results The survey revealed that 81% of participants reported drinking hazardously. Thematic analysis of the interview data indicated many students perceived college as a supportive environment regarding students' alcohol use choices (direct peer pressure to drink was uncommon). However, indirect social influence to drink appeared to maintain a ‘culture of intoxication’. Specifically, social norms to attend college events (where drinking is implied) and modelling of excessive drinking were key indirect influences on heavy drinking norms. Students were aware and accepting of many alcohol harm minimisation strategies and interested in improving current strategies. Discussion and Conclusions Despite the supportive college environment described by students, regarding alcohol use choices, a ‘culture of intoxication’ driven by indirect social influences was evident. Student leaders' interest in increasing the availability of harm minimisation strategies highlights the potential utility of peer‐led alcohol interventions in colleges.
Assessment of Rotational Thromboelastometry and Thrombin Generation Assay to Identify Risk of High Blood Loss and Re-Operation After Cardiac Surgery

Introduction: We aimed to investigate parameters for prediction of post-operative blood loss and re-operation in patients who underwent cardiopulmonary bypass. Methods: Thrombin generation assay, activated partial thromboplastin time, activated clotting time and rotational thromboelastometry (ROTEM) tests were performed at 4 time points in 65 patients: before skin incision (T1), after heparin injection (T2), after protamine reversal (T3) and before skin closure (T4). Results: Pre-operative endogenous thrombin potential (ETP) and peak thrombin levels were significantly lower in patients with high post-operative blood loss (≥ 800 mL) within 24 h than in those with low blood loss (< 800 mL). Clotting time (CT), maximal clotting firmness, clotting firmness time and alpha angle values of ROTEM measured at T2, T3 or T4 were significant predictors for high post-operative blood loss. An increase in CT-EXTEM over 4 time points was significant in patients who had a re-operation within 48 h compared to their counterparts. Conclusions: This study indicates that pre-operative ETP could predict high post-operative blood loss and that intra-operative ROTEM also helps to stratify risks of high post-operative blood loss and re-operation.
Association of VKORC1 polymorphisms and major bleedings in patients who are treated with vitamin K antagonists

Research results are conﬂicting on whether the single nucleotide polymorphism rs9923231 ( − 1639G > A) of vitamin K epoxide reductase complex subunit-1 (VKORC1) is associated with increased major bleeding during treatment with vitamin K antagonists (VKAs) [1–6]. Furthermore, it is unclear whether additional risk factors, such as a high international normalized ratio (INR), further increase the risk for major bleeding. Our aim was to determine the association of VKORC1 1639 G > A with major bleeding and to determine whether a high INR further increased the risk of major bleeding. In short, patients were eligible for the BLEED cohort study if they were at least 18 years old and started VKAs for a planned duration of at least 6 weeks at one of the three participating anticoagulation clinics [7]. Consent was given by means of an opt-out procedure which led to 16,570 (99%) included patients out of 16,706 eligible patients. The BLEEDS was approved by the medical ethical committee of the Leiden University Medical Center [7]. Baseline characteristics and follow-up data were collected from Dutch anticoagulation clinics. Follow-up started from initiation of VKA until the outcome major bleeding, death or the end of the study. Information about major bleeding was acquired through standardized interviews during every anticoagulation clinic visit and were classiﬁed by physicians not involved in the study. Bleeding events were classiﬁed as major if these were fatal, intracranial, an objectively diagnosed joint bleed, a bleeding event in a critical organ, or if they led to a blood transfusion or to a hospi-tal admission [8]. Furthermore, DNA was collected from 13,790 patients (83%) 3 weeks after initiating VKAs. For this study, we assembled a case–cohort study, containing all 326 cases with major bleeding and a random
Introduction to Quantum Groups and Crystal Bases

Lie algebras and Hopf algebras Kac-Moody algebras Quantum groups Crystal bases Existence and uniqueness of crystal bases Global bases Young tableaux and crystals Crystal graphs for classical Lie algebras Solvable lattice models Perfect crystals Combinatorics of Young walls Bibliography Index of symbols Index.
Interferon-γ Is Protective in Cytokine Release Syndrome-associated Extrapulmonary Acute Lung Injury.

The mechanisms by which excessive systemic activation of adaptive T lymphocytes, as in cytokine release syndrome (CRS), leads to innate immune cell-mediated acute lung injury (ALI) or acute respiratory distress syndrome (ARDS), often in the absence of any infection, remains unknown. Here, we investigated the roles of interferon (IFN)- and IL-17A, key T cell cytokines that are significantly elevated in CRS patients, in the immunopathogenesis CRS-induced extrapulmonary ALI (eALI). CRS was induced in wild-type (WT), IL-17A- and IFN--knockout (KO) human leukocyte antigen (HLA)-DR3 transgenic mice with 10 g of the superantigen, staphylococcal enterotoxin B (SEB), given intraperitoneally. Several ALI parameters including gene expression profiling in the lungs were studied 4, 24 or 48 hours later. Systemic T cell activation with SEB resulted in robust upregulation of several chemokines, S100A8/A9, matrix metalloproteases and other molecules implicated in tissue damage, granulocyte as well as agranulocyte adhesion and diapedesis in the lungs as early as 4 hours, which was accompanied by subsequent neutrophil/eosinophil lung infiltration and severe ALI in IFN-KO mice. These pathways were significantly under-expressed in IL-17AKO mice which manifested mildest ALI and intermediate in WT mice. Neutralization of IFN- worsened ALI in WT and IL-17AKO mice, whereas neutralizing IL-17A did not mitigate lung injury in IFN-KO mice, suggesting a dominant protective role for IFN- in ALI and that IL-17A is dispensable. Ruxolitinib, a Janus kinase inhibitor, increased ALI severity in WT mice. Thus, our study identified novel mechanisms of ALI in CRS and its differential modulation by IFN- and IL-17A.
Colorectal Cancer in Childhood-onset Inflammatory Bowel Disease: A Scandinavian Register-based Cohort Study, 1969–2017

Through linkage of data from Danish and Swedish national registers we identified 6937 patients with childhood (<18 years)-onset Crohn disease (CD), 8514 patients with childhood-onset ulcerative colitis (UC) and up to 10 times as many matched (sex, age, residence) reference individuals 1969–2017. During follow-up to a median age of 27 (interquartile range = 21–39) years, 25 (0.36%) CD patients were diagnosed with colorectal cancer (CRC) versus 43 (0.06%) reference individuals, and 113 (1.33%) UC patients versus 45 (0.05%) reference individuals. The hazard ratio (HR) for CRC was 6.46 (95% CI = 3.95–10.6) in CD and 32.5 (95% CI = 23.0–45.9) in UC and increased with decreasing age at diagnosis. The HR for CRC was increased for all phenotypes, but with higher estimates for colonic CD [17.9 (95% CI = 7.43–43.3)] and UC with extensive/pancolitis [36.3 (95% CI = 22.8–57.8)]. The relative risk of CRC was increased for all phenotypes of childhood-onset inflammatory bowel disease. Age at onset may be considered an additional risk factor when implementing surveillance programs.
An in-silico analysis of experimental designs to study ventricular function: A focus on the right ventricle

In-vivo studies of pulmonary vascular disease and pulmonary hypertension (PH) have provided key insight into the progression of right ventricular (RV) dysfunction. Additional in-silico experiments using multiscale computational models have provided further details into biventricular mechanics and hemodynamic function in the presence of PH, yet few have assessed whether model parameters are practically identifiable prior to data collection. Moreover, none have used modeling to devise synergistic experimental designs. To address this knowledge gap, we conduct a practical identifiability analysis of a multiscale cardiovascular model across four simulated experimental designs. We determine a set of parameters using a combination of Morris screening and local sensitivity analysis, and test for practical identifiability using profile likelihood-based confidence intervals. We employ Markov chain Monte Carlo (MCMC) techniques to quantify parameter and model forecast uncertainty in the presence of noise corrupted data. Our results show that model calibration to only RV pressure suffers from practical identifiability issues and suffers from large forecast uncertainty in output space. In contrast, parameter and model forecast uncertainty is substantially reduced once additional left ventricular (LV) pressure and volume data is included. A comparison between single point systolic and diastolic LV data and continuous, time-dependent LV pressure-volume data reveals that at least some quantitative data from both ventricles should be included for future experimental studies.
Reversal of idiopathic hypogonadotropic hypogonadism in a Chinese male cohort

Idiopathic hypogonadotropic hypogonadism (IHH) is a rare genetically heterogeneous disease and characterized by incomplete or absent puberty and infertility. It is worth noting that partial IHH patients could recover reproductive endocrine function following treatment, which is termed reversal. This study aimed to investigate clinical and genetic characteristics of IHH reversal patients. A total of 141 IHH male patients were enrolled and followed up regularly. Their clinical and genetic features were collected and analysed to discover something in common in reversal cases. These IHH patients with a median age of 21 years (interquartile range: 18–24) were divided into reversal group (n = 13) and non‐reversal group (n = 128). IL17RD, ERBB4, DLX5, EGFR, SEMA4D, B3GNT1 and CCKAR RSVs were demonstrated in reversal cases for the first time. Pathogenic/likely pathogenic (P/LP) RSVs consisted of 3 RSVs (one each patient, including PROKR2 p.W178S, EGFR p.G630R and CCKAR p.S291del) in reversal group. Reversal of IHH could not be ignored in clinical follow‐up. Patients with high levels of basal LH and T may harbour more possibility of reversal and worthy extra attention to identify whether reversal occurs or not. Relapse after reversal also needs to be monitored.
Success factors when implementing a structured support model for systematic work environment management in operating departments: A case study from Sweden

Abstract Aim The study aimed to investigate how departments in a Swedish hospital worked with a structured support model between the sessions and what they identified as success factors. Background To improve the work environment in a Swedish hospital, a structured support model for systematic work environment management was implemented in operating departments. The structured work starts with sending a web‐based, open‐ended, anonymous questionnaire to all employees. In response, employees describe how they perceive their work environment ‘right now’. Next, a session is held where employees' viewpoints are discussed, and areas of improvement are agreed upon. Action plans are created between the sessions, and the employees start working with their plans with support from their managers. Implementing new models takes time and requires efforts from employees and managers. Method A case study was conducted, including three operating departments within a perioperative organization in a university hospital in Sweden. The participating departments had used the model without interruption during the Covid‐19 pandemic 2 years after implementation, and they had created a customized working method. Three first‐line managers were interviewed, and 22 action plans, 21 workplace meeting notes and two presentations were analysed using thematic analysis. Results The results are sorted under three main thematic headings: Experience of results and benefits, Marketing and cheering on and Making adjustments and making the model one's own. The results from the action plans and workplace meetings indicated that the employees had discussed problems with cooperation, work organization and how to treat each other. Conclusion Human factors, such as support, encouragement, seeing the benefits, allowing for time and respecting each other can facilitate and contribute to the implementation and success of a new model. Implications for Nursing Management The main finding of the study indicates that with a structured way of working, and with the participation of the employees in the systematic work environment work, the employees contributed with constructive suggestions for improvement. This, in turn, contributed to reducing the workload for first‐line managers. In addition, when working with a structured model, deficiencies in the workplace were identified, which triggered an improvement process in the participating hospital departments.