Miracle-dz/UniFAR-FTUs huggingface dataset:
A Low-Profile SIW-Based CTS Array with Reconfigurable Four Beams and Dual Polarizations for K-Band Sensing

A dual-polarized continuous transverse stub (CTS) K-band antenna with reconfigurable four beams and low profile is proposed based on substrate-integrated-waveguide (SIW) design. It consists of a line source generator (LSG) on the bottom surface, a spherical-wave to plane-wave transforming part on the middle layer, and CTS radiators on the top surface. Particularly, the LSG has four SIW-based H-plane horns, and a chip is integrated to switch among the two pairs of horns, so as to transfer the quasi-TEM waves on the bottom surface by a ±10° deflection angle to the middle layer for the CTS radiators on the top surface, resulting in four reconfigurable scanning beams with 10° for two polarizations. The measurements show that it realizes four reconfigurable beams with a 25.8 dBi gain at 24 GHz, verifying the design. The proposed antenna takes into account the advantages of reconfigurable multi-beam, dual polarization, low side lobes, low profile, and high gain, which can be applied to K-band sensing, especially for wind profile radars.
The Intestinal Redox System and Its Significance in Chemotherapy-Induced Intestinal Mucositis

Chemotherapy-induced intestinal mucositis (CIM) is a significant dose-limiting adverse reaction brought on by the cancer treatment. Multiple studies reported that reactive oxygen species (ROS) is rapidly produced during the initial stages of chemotherapy, when the drugs elicit direct damage to intestinal mucosal cells, which, in turn, results in necrosis, mitochondrial dysfunction, and ROS production. However, the mechanism behind the intestinal redox system-based induction of intestinal mucosal injury and necrosis of CIM is still undetermined. In this article, we summarized relevant information regarding the intestinal redox system, including the composition and regulation of redox enzymes, ROS generation, and its regulation in the intestine. We innovatively proposed the intestinal redox “Tai Chi” theory and revealed its significance in the pathogenesis of CIM. We also conducted an extensive review of the English language-based literatures involving oxidative stress (OS) and its involvement in the pathological mechanisms of CIM. From the date of inception till July 31, 2021, 51 related articles were selected. Based on our analysis of these articles, only five chemotherapeutic drugs, namely, MTX, 5-FU, cisplatin, CPT-11, and oxaliplatin were shown to trigger the ROS-based pathological mechanisms of CIM. We also discussed the redox system-mediated modulation of CIM pathogenesis via elaboration of the relationship between chemotherapeutic drugs and the redox system. It is our belief that this overview of the intestinal redox system and its role in CIM pathogenesis will greatly enhance research direction and improve CIM management in the future.
A UNIQUE MODULATOR FOR BOOST REGULATOR TO REDUCE THE VOLTAGE STRESS

The APS control can be used to lessen the current force on switches see how to avoid load as the traditional interleaving control can be used to help keep better performance in heavy load. This paper looks into a manuscript pulse width modulation (PWM) plan for 2-phase interleaved boost ripper tools with current multiplier for fuel cell power system by mixing alternating phase shift (APS) control and traditional interleaving PWM control. To be able to reduce output fuel cell stack output current ripple or even the electricity/electricity ripper tools input current ripple, whether passive filter or active filter may be used, however, this will raise the complexity from the system. The boundary condition for swapping between APS and traditional interleaving PWM control comes. In line with the aforementioned analysis, a complete power range control mixing APS and traditional interleaving control is suggested. Loss breakdown analysis can also be given look around the efficiency from the ripper tools. Finally, it's verified by experimental results. The whole process of a switching cycle from the ripper tools could be split into six stages at boundary condition that the current force on switch is going to be bigger than 1 / 2 of the output current with traditional interleaving control.
Conceptualization and practices in digital health: voices from Africa

This paper presents voices from Africa on digital health in Africa. These voices were gleaned during interviews and an online, focus group session in May 2020, during which 30 experts across Africa, among others from the South, were asked about their experiences and observations on the conceptualisation of, and practices in, digital health in their respective communities and countries. Extensive input was provided, both orally and textually. The quotes gathered and presented in this paper indicate that there is a distinct need for the respectful co-development of digital health interventions in Africa. In addition, the quotes show how a one-size-fits-all solution approach does not exist, it is not a solution to Africa. Further, the community-focus, fit, and fragmentation of existing activities digital health interventions is questioned. The narratives provide a rich resource indicating capable and local agency and the need to address power-differences in international health development.
Hopes and Challenges: Translational Medical Research in Bladder Cancer

Bladder cancer is a complex disease and could be classified into non-muscle-invasive or muscle-invasive subtypes according to the distinct genetic background and clinical prognosis. It is necessary to find a non-invasive, economical and efficient method for the diagnosis and treatment of bladder cancer. Translational medicine provides such an opportunity. Genomics, proteomics, molecular biology, bioinformatics and the like that aid in studying and exploring the mechanism of bladder cancer development, bladder cancer-related genes, signalling pathways, key molecules or targets can be clearly used for the diagnosis and treatment of bladder cancer. Biomarkers have been developed as part of a new detection kit for the early screening, diagnosis and recurrence monitoring of bladder cancer through translational medicine. Additionally, targeted drugs and immunological preparations can be used for the treatment of bladder cancer and further improve its existing diagnosis, treatment and prognosis.
Endothelial Dysfunction and Ischemia-Modified Albumin Levels in Males with Diabetic and Nondiabetic Erectile Dysfunction

In this study, we aimed to determine endothelial dysfunction and ischemia-modified albumin (IMA) levels in patients diagnosed with erectile dysfunction (ED) and to examine the relationship between these and diabetes disease. 86 male patients (46 patients with diabetes, age: 51.5 ± 9.2 and 40 patients with nondiabetes (control group), age: 54.78 ± 12.2) were included in the study. IMA, a new indicator of tissue ischemia and oxidative stress, was checked. Superoxide dismutase (SOD) activity, another oxidative stress indicator, was examined. Endothelin-1 (ET-1), one of the parameters of endothelial dysfunction, was measured. Additionally, endothelial function was evaluated with flow-mediated vasodilatation (FMD). Student's t-test was used for statistical evaluation. p values less than 0.05 were considered statistically significant. SOD activity was significantly lower in the diabetic group than in the control group, and ET-1 was significantly higher (p < 0.001). IMA was found to be significantly higher in the diabetic group than the control group (p < 0.001). FMD was significantly lower in diabetic group compared to the control group (p < 0.002). According to our findings, the co-occurrence of erectile dysfunction and diabetes demonstrates a complex condition that includes endothelial dysfunction, oxidative stress, and tissue ischemia. When the correlation of indicators, which are markers, was examined, the severity of the co-occurrence of diabetes and erectile dysfunction was again demonstrated.
Engineering Multifunctional Hydrogel With Osteogenic Capacity for Critical-Size Segmental Bone Defect Repair

Treating critical-size segmental bone defects is an arduous challenge in clinical work. Preparation of bone graft substitutes with notable osteoinductive properties is a feasible strategy for critical-size bone defects. Herein, a biocompatible hydrogel was designed by dynamic supramolecular assembly of polyvinyl alcohol (PVA), sodium tetraborate (Na2B4O7), and tetraethyl orthosilicate (TEOS). The characteristics of the supramolecular hydrogel were evaluated by rheological analysis, swelling ratio, degradation experiments, and scanning electron microscopy (SEM). In in vitro experiments, this TEOS-hydrogel had self-healing property, low swelling rate, degradability, good biocompatibility, and induced osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by upregulating the expression of Runx-2, Col-1, OCN, and osteopontin (OPN). In segmental bone defect rabbit models, the TEOS-containing hydrogel accelerated bone regeneration, thus restoring the continuity of bone and recanalization of the medullary cavity. The abovementioned results demonstrated that this TEOS-hydrogel has the potential to realize bone healing in critical-size segmental bone defects.
Intelligent Non-Orthogonal Beamforming with Large Self-Interference Cancellation Capability for Full-Duplex Multi-User Massive MIMO Systems

This work introduces a novel full-duplex hybrid beamforming (FD-HBF) technique for the millimeter-wave (mmWave) multi-user massive multiple-input multiple-output (MU-mMIMO) systems, where a full-duplex (FD) base station (BS) simultaneously serves half-duplex (HD) downlink and uplink user equipments over the same frequency band. Our main goal is jointly enhancing the downlink/uplink sum-rate capacity via the successful cancellation of the strong self-interference (SI) power. Furthermore, FD-HBF remarkably reduces the hardware cost/complexity in the mMIMO systems by interconnecting the radio frequency (RF) and baseband (BB) stages via a low number of RF chains. First, the RF-stage is constructed via the slow time-varying angular information, where two schemes are proposed for both maximizing the intended signal power and canceling the SI power. Particularly, orthogonal RF beamformer (OBF) scheme only aims canceling the far-field component of SI, while non-orthogonal RF beamformer (NOBF) scheme applies perturbations to the orthogonal beams for also suppressing the near-field component of SI channel. Considering the high computational complexity during the search for optimal perturbations, we apply swarm intelligence to find the optimal perturbations. Second, the BB-stage is designed based on only the reduced-size effective intended channel matrices, where the BB precoder/combiner solutions are obtained via regularized zero-forcing (RZF) and minimum mean square error (MMSE). Hence, the proposed FD-HBF technique does not require the instantaneous SI channel knowledge. It is shown that FD-HBF with NOBF+MMSE achieves 78.1 dB SI cancellation (SIC) on its own. Additionally, FD-HBF with the practical antenna isolation can accomplish more than 130 dB SIC and reduce the SI power below the noise floor. The numerical results present that FD-HBF greatly improves the sum-rate capacity by approximately doubling it compared to its HD counterpart.
Influencia de la insatisfacción corporal y la actividad física en el bienestar psicológico de jóvenes mexicanas (Influence of body dissatisfaction and physical activity on the psychological well-being of young Mexican women)

El objetivo principal del presente estudio fue examinar el efecto de la insatisfacción con la imagen corporal y la práctica de actividad física sobre la percepción de bienestar psicológico en jóvenes mexicanas mediante un modelo de ecuaciones estructurales. Un total de 488 estudiantes universitarias mexicanas de 18 a 24 años de edad contestaron las versiones cortas de los cuestionarios Multidimensional Body Self Relations Questionnaire, Cuestionario Internacional de Actividad Física y Bienestar Psicológico de Ryff. Los resultados del modelo de ecuaciones estructurales mostraron que la práctica de actividad física, a través de la importancia subjetiva de la forma y la apariencia físicas, tiene un efecto indirecto positivo sobre la percepción de bienestar psicológico en la dimensión de autoaceptación y ésta a su vez ejerce un efecto directo positivo sobre el crecimiento personal. El modelo propuesto obtiene un ajuste satisfactorio, explicando el 38% de la varianza en la percepción de bienestar psicológico en la dimensión de crecimiento personal (variable criterio). Summary. The main objective of the present study was to examine the effect of dissatisfaction with body image and the practice of physical activity on the perception of psychological well-being in young Mexican women using a structural equation model. A total of 488 Mexican university students between the ages of 18 and 24 answered the short versions of Ryff's Multidimensional Body Self Relations Questionnaire, International Questionnaire on Physical Activity and Psychological Well-being. The results of the structural equations model showed that the practice of physical activity, through the subjective importance of physical shape and appearance, has a positive indirect effect on the perception of psychological well-being in the self-acceptance dimension and this in turn it has a direct positive effect on personal growth. The proposed model obtains a satisfactory fit, explaining 38% of the variance in the perception of psychological well-being in the dimension of personal growth (criterion variable).
Measuring menu attributes in the international and local resort hotels in Egypt

Abstract This study will be the first attempt to examine menu attributes, i.e. menu item descriptions, menu design and menu variety as effective marketing tools for Sharm El-Sheikh resort hotels (SESRHs) in Egypt. Fifteen semi-structured interviews were conducted with Food and Beverage (F&B) Managers and Executive Chefs (ECs). The findings indicate that the sampled RHs replied primarily on restaurants’ service employees to promote their menu items. However, service employees can become disinterested with repeating verbally menu items for every customer. This study suggests a theoretical model of using menu attributes as marketing tools for SESRHs. The present study provides a basis for future research in relation to menu attributes.
Virtual Prototype driven Design, Implementation and Evaluation of RISC-V Instruction Set Extensions

RISC-V is a modern open source Instruction Set Architecture (ISA) and designed in a very extendable manner, which allows for highly application specific solutions. However, the identification of suitable instruction set extensions usually requires a significant manual effort and therefore is a very challenging process. In this paper we propose a lightweight alternative methodology to find suitable application-specific RISC-V extensions, using a Virtual Prototype (VP). This is done, purely by observing the used instructions during the execution of the targeted application on the VP. Therefore, no further information about the application itself are needed. In this context the advantages and the flexibility of a VP and the straightforward extendability of the RISC-V ISA are demonstrated.
Model assisted biosignal analysis of atrial electrograms

Abstract Cardiologists measure electric signals inside the human heart aiming at a better diagnosis and optimized therapy of atrial arrhythmias like atrial flutter and atrial fibrillation. The catheters that are used for this purpose are improving: now they are able to pick up the electric signals at up to 64 positions inside the heart simultaneously. The patterns of electric depolarization are sometimes very simple, comparable to plane waves. But in case of patients with severe atrial arrhythmias they can be quite complex: U-turns around a line of block, ectopic centres, break throughs, reentry circuits, rotors, fractionated signals and chaotic patterns are often observed. Methods of biosignal analysis can support the cardiologists in classifying the signals and extract information of high diagnostic relevance. Computer models of the electrophysiology of the human heart can serve to design better algorithms for data analysis and to test algorithms, because the “ground truth” is known.
Abiotic passive nitrogen and methane enrichment during exhumation of subducted rocks: Primary multiphase fluid inclusions in high‐pressure rocks from the Cabo Ortegal Complex, NW Spain

Primary multiphase fluid inclusions (MFI) were studied in one eclogite and two granulites from the Cabo Ortegal Complex (COC, NW Spain) by means of Raman imaging, Scanning Electron Microscopy with Energy Dispersive Spectroscopy (SEM‐EDS) and Focused Ion Beam ‐ Scanning Electron Microscopy (FIB)‐SEM. Complementary, secondary MFI in pyroxenites from COC were also investigated. MFI hosted in eclogite and granulites occur along growth zones or in 3D clusters in garnet porphyroblasts suggesting a primary origin at high‐pressure (HP) metamorphic conditions. The mineral assemblage of MFI is mainly composed of Fe‐Mg‐Ca‐carbonates and phyllosilicates ± graphite ± quartz ± corundum ± pyrite ± apatite ± rutile and a fluid phase composed of nitrogen ± methane ± carbon‐dioxide. The mineral proportions vary among the lithologies. Dominant carbonates and hydrous silicates are interpreted as step‐daughter minerals (crystals formed in the MFI after entrapment as a result of fluid–host interaction), whereas apatite, quartz and rutile are considered in part as accidentally trapped minerals since they also occur as crystal inclusions together with MFI in each rock type. Quartz and corundum occur together in MFI in ultramafic granulite and are regarded as step‐daughter minerals in this lithology. These observations suggest that the MFI are products of post‐entrapment reactions of a homogeneous COHN fluid system with the host mineral. Thermodynamic calculations in the CaFMAS‐COHN system confirmed that bulk composition of the MFI in eclogite is similar to the host garnet+COHN composition except for a potential lost of H2O. Carbonation and hydration reaction between the host (i.e. garnet or pyroxene) and the fluid inclusion results in the consumption of all CO2 and part of the H2O from the fluid phase producing Ca‐Fe‐Mg‐carbonates and hydrous step‐daughter minerals, mostly pyrophyllite and chlorite. Nitrogen content of the originally trapped COHN fluid in eclogite was estimated to have a maximum value of 10 mol% at peak HP conditions and 30–40 mol% at retrograde conditions that is within the range of the observed MFI in the residual fluid (13–68 mol%). Pseudosection modelling confirmed the stability of the phase assemblage in the MFI in a specific low‐pressure, low‐temperature stability field (between 300°C and 400°C at pressures < 1 GPa), caused by H2O‐ and CO2‐consuming reactions possibly in a single step. Our findings indicate that such processes in the exhuming HP units may play a role in global nitrogen and carbon cycling as well as potentially contributing to nitrogen and methane supply to subsurface–surface environments during devolatilization in the forearc regions of convergent plate margins.
Development and Scalable Production of Newcastle Disease Virus-Vectored Vaccines for Human and Veterinary Use

The COVID-19 pandemic has highlighted the need for efficient vaccine platforms that can rapidly be developed and manufactured on a large scale to immunize the population against emerging viruses. Viral-vectored vaccines are prominent vaccine platforms that have been approved for use against the Ebola virus and SARS-CoV-2. The Newcastle Disease Virus is a promising viral vector, as an avian paramyxovirus that infects poultry but is safe for use in humans and other animals. NDV has been extensively studied not only as an oncolytic virus but also a vector for human and veterinary vaccines, with currently ongoing clinical trials for use against SARS-CoV-2. However, there is a gap in NDV research when it comes to process development and scalable manufacturing, which are critical for future approved vaccines. In this review, we summarize the advantages of NDV as a viral vector, describe the steps and limitations to generating recombinant NDV constructs, review the advances in human and veterinary vaccine candidates in pre-clinical and clinical tests, and elaborate on production in embryonated chicken eggs and cell culture. Mainly, we discuss the existing data on NDV propagation from a process development perspective and provide prospects for the next steps necessary to potentially achieve large-scale NDV-vectored vaccine manufacturing.
Why do we still have not a vaccine against Chagas disease?

This review does not intend to convey detailed experimental or bibliographic data. Instead, it expresses the informal authors’ personal views on topics that range from basic research on antigens and experimental models for Trypanosoma cruzi infection to vaccine prospects and vaccine production. The review also includes general aspects of Chagas’ disease control and international and national policies on the subject. The authors contributed equally to the paper.
Coupling of ASTEC V2.1 and RASCAL 4.3 Codes to Evaluate the Source Term and the Radiological Consequences of a Loss-of-Cooling Accident at a Spent Fuel Pool

This paper deals with a general methodology to evaluate the Source Term (ST) and the Radiological Consequences (RC) of a hypothetical Severe Accident at a Fukushima-like Spent Fuel Pool by coupling ASTEC 2.1 and RASCAL 4.3 severe accident and consequence projections codes, respectively. The methodology consists of two steps: the ST provided by a priori simulation performed by ASTEC V2.1 code was used as input to RASCAL 4.3 code to make an RC analysis. This approach was developed as a preparatory study for the Management and Uncertainties in Severe Accident (MUSA) H2020 European Project, coordinated by CIEMAT, where the ENEA's Nuclear safety laboratory is committed to perform an analysis on a Fukushima-like SFP with the aim to apply innovative management of SFP accidents (WP6) to mitigate the RC of the accident itself. To perform the RC studies that could have an impact on Italy, a Fukushima-like SFP was assumed located in one of the Italian cross-border NPPs. The weather data adopted are both standard and real hourly meteorological data taken from more than one geographical location. The results of the RC for 96 hours of ST release in a range of 160 km from the emission point are reported in terms of Total Effective Dose Equivalent, Thyroid dose, and Cs-137 total ground deposition. The mitigating effect on ST and on RC of the cooling spray system (CSS) actuated with several pH values (i.e., 4,7,10) was also investigated.