Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship Between Diabetes Mellitus and the Prognosis of Ischemic Heart Failure

Background: Ischemic heart failure (IHF) is an important type of heart failure (HF). The aim of this study is to analyze the clinical features of IHF, investigate the prognostic value of clinical risk factors, especially DM-related factors, on the IHF patients, so as to provide reference for the high-quality health management of IHF patients.Methods: A total of 430 IHF patients were divided into comorbid (IHF+ DM) group or IHF group according to whether they had DM in this cross sectional and prospective study. The patients were collected for their clinical information, and were followed up for 3.3 years to record the composite clinical endpoints including all-cause death, stroke, myocardial infarction and decompensated heart failure. The prognostic value of DM-related and other traditional risk factors with IHF were evaluated. Results: Among 430 patients with IHF, 176 had DM. Compared with the IHF group, the IHF + DM group had higher prevalence of hypertension and overweight, higher levels of FPG and HbA1c, higher proportion of patients in NYHA III – IV grade, larger left ventricular end diastolic diameter (LVEDD) in male group, higher Gensini score and shorter distance of 6-minute walk test (6-MWT). After a median follow-up of 3.3 years, a total of 156 patients (36.3%) had experienced clinical endpoint events. Kaplan Meier analysis showed that the IHF patients with DM history, and higher HbA1c or FPG level would significantly reduce the cumulative survival rates of composite clinical endpoints, as well as the cumulative survival rates of all-cause death and cardiovascular death (all P < 0.05). Cox regression analysis indicated that DM history and higher PFG or HbA1c levels were independently associated with the all-cause death, cardiovascular death, and composite endpoints (all P < 0.05). The incorporation of diabetes related factors (diabetes history, FPG and HbA1c) significantly increased the area under the receiver operating characteristic (ROC) curve of the risk model established by the traditional risk factors (0.803 vs. 0.775, P= 0.039). In addition to DM history, male sex, uric acid ≥ 400 μmol / L, creatinine ≥ 100 μmol / L, Gensini score > 80 and ACEF score were all independent risk factors for the occurrence of composite clinical endpoints in IHF patients.Conclusion: There existed a high incidence rate of DM in the IHF population. The diabetes related factors (diabetes history, FPG, HbA1c) significantly increased the predictive value of the risk model made by the basic risk factors in predicting the IHF outcomes. DM history, male, uric acid ≥ 400 μmol / L, creatinine ≥ 100 μmol / L, Gensini score > 80 and ACEF score were independent risk factors for the occurrence of composite clinical endpoints in IHF patients.
Evaluation of Micro-Scale Syngas Production Costs through Modeling

Feasibility of biomass gasification is very much dependent on the cost of the gasification facility and its operation. A cost analysis model was accordingly developed to analyze the unit cost of syngas production from micro-scale biomass gasification facilities. Costs considered included all capital and operating costs. The model was applied to evaluate a scenario for Mississippi in 2008. Results of the modeling indicated that operating cost was the major part of the syngas production cost, and the single-shift operating cost could be up to 83.64% of the total annual cost of syngas production at the 60 Nm3 h-1 capacity level. Labor cost was the largest part of the operating cost and the total annual cost. The labor cost could be up to 73.60% of the total of annual operating cost and 61.56% of the total annual cost of syngas production. The unit cost and energy cost of syngas production of the 60 Nm3 h-1 facility were $0.55 Nm-3 and $0.095 MJ-1, respectively, which were higher than the $0.357 Nm-3 and $0.009 MJ-1 natural gas average retail prices in the U.S. in the fourth quarter of 2008. When the production capacity increased, the total syngas production annual cost continually increased, but the syngas unit cost markedly decreased. Therefore, the effective way to reduce costs is to plan for a higher-capacity micro-scale facility. Sensitivity analysis showed that, from the lower bound to the upper bound of the production capacity range tested (60 to 1800 Nm3 h-1), there was a shift from labor cost to equipment cost as the factor of greatest influence on syngas unit cost. Such information provided by the model identifies considerations for planning and/or operating micro-scale gasification facilities. The model can be a tool for analyzing the economics of syngas production and, in that regard, it can generate useful information for the design of smaller gasification plants.
Analytical model for proton radiation effects in bipolar devices

The input bias current response of LM124 operational amplifiers to proton irradiation is shown to correlate with the response of identical part types exposed to neutrons and, subsequently, irradiated with X-rays. Moreover, the bias current responses to proton and combined neutron/X-ray exposures are more sublinear than the sum of neutron and X-ray radiation responses measured independently. These data indicate that the ionization defects introduced by proton irradiation moderate the effects of proton-induced displacement damage in the critical bipolar transistors within the LM124. An analytical model is presented that characterizes the various mechanisms of proton radiation effects in bipolar transistors, including the combined effects of oxide charge and bulk traps on carrier recombination. Prototype transistor responses simulated using the model show good correlation with the sublinear characteristics observed in the experimental data. Furthermore, the model is used to assess whether a bipolar junction transistor (BJT), designed with specific structural characteristics and operating in a proton-rich environment, will suffer the most degradation from damage caused by bulk displacement, ionization damage, or a combination of both.
Theoretical approach for target detection and interference cancellation in passive radars

Many studies have been done so far based on the detection theory for target detection in active radars, but not for passive radars. Owing to some substantial differences, detection methods used in active radars do not lead to accurate results if applied to passive radars. So, in the current study, cancellation, detection and target parameter extraction are investigated for passive radar based on the detection theory. To do this, the passive radar hypothesis test is written in the form of a multiple composite test. Unknown parameters are estimated using maximum likelihood (ML) criterion for the achievement of generalised likelihood ratio test detection statistic and elimination of direct path and clutter that contain nuisance parameters. The required threshold is set so that the false alarm probability in each cell and each step would become a constant value. Also, since this method requires heavy computations, a method for the reduction of computational complexity is proposed. Finally, various detection methods in passive radars are compared using simulation to show the effectiveness of the suggested method.
Thermal Effects Analysis of Flip Chip LED Packages with through Silicon via (TSV) by Using Numerical Simulation

With advancement of technology, package sizes and products are becoming smaller due to miniaturization. Separate light-emitting diode (LED) chips and control integrated circuits with through silicon via (TSV) structurescan be combined to achieve reduced size. LED chipswithFlip Chip structureare capable of higher optical efficiency and heat dissipation. Analysis of LED chip structure after heat-related destruction of the chip indicated that the chip suffered stress from heating and cooling. The material used for TSV structures is copper, sincethis provides good electrical conductivity and high thermal conductivity. However, the thermal expansion coefficient of copper is higher than for other materials and can result in thermal expansion coefficient mismatch. Hence, the use of this material is likely to cause stress concentration and thus cause damage. In this study, molybdenum and tungsten were tested as replacements for copper in TSV, and the modified TSV was subjected to simulation analysis.The results indicate that replacement of TSV materials can reduce thermal expansion coefficient mismatch and consequent stress fracture and that the performance of different materials can be simulated by Fatigue Analysis and Load.
Increasing complexity of primitive compartments

Corresponding authors: Tony Z. Jia, Earth-Life Science Institute, Tokyo Institute of Technology, 2-12-1-IE-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan. Blue Marble Space Institute of Science, 1001 4th Ave., Suite 3201, Seattle, Washington 98154, USA. ORCID iD: https://orcid.org/0000-0001-5175-4599, e-mail: tzjia@elsi.jp; Yutetsu Kuruma, Extra-cutting-edge Science and Technology Avant-garde Research Program, Japan Agency for Marine-Earth Science and Technology, 2-15 Natsushimacho, Yokosuka, Kanagawa 237-0061, Japan. Japan Science and Technology Agency, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. ORCID iD: https://orcid.org/0000-0001-8147-5646, email: ykuruma@jamstec.go. jp Biophysics and Physicobiology
An overview on energy conservation in automobile traffic and transportation with ITS

This paper surveys the effects of intelligent transport systems (ITS) on energy conservation. ITS could improve traffic flow to prevent congestion, leading to energy conservation. Traffic signal control systems enable automobiles to go through intersections without stopping, and electronic toll collection systems eliminate stopping at tollgates. With route guidance systems, drivers can reach their destinations along the optimal routes. Vehicle control systems increase the effective road capacity by shortening the inter-vehicle gap and lane width. The effects of ITS on energy conservation are expected to be a 13 % decrease in fuel consumption in the year 2025 in Japan.
A simple approach to voltage stability assessment in radial networks

Analytical approach to voltage collapse proximity determination is proposed for radial networks. Under corresponding assumptions, a radial network with arbitrary bus loads is transformed into a two bus equivalent. The voltage phasors at the generator bus and at the last load bus of the radial network are transformed to form the voltage phasors of the two bus equivalent. The latter are further used for assessment of voltage collapse proximity. Exact stability limit relations for a two bus system derived from Jacobian matrix can be exploited. Moreover, an analytical expression is derived for calculation of active and reactive power reserve margins for a radial network equivalent. The proposed procedure has been tested for practical examples of radial networks with inductive and capacitive loads.
Multi-resonant Non-Inverting Buck-Boost Converter

A DC-DC converter having buck-boost characteristics is proposed in this paper. The converter operation is based on the two resonators switched in between input and output ports having different characteristics frequencies. The resonant operation not only helps transfer energy but also to reduce losses using zero-current operation. The converter’s multimode operation is explained under two modes identified using the output voltage regulation. In the unregulated mode, there is fixed voltage gain and zero-current at the turn-on and -off instances of all semiconductor devices. However, in the regulated mode, a set of semiconductor devices have hard turn-off. The converter operation in both modes is analyzed and validated using simulation results. Furthermore, the effects of parasitic elements of active and passive devices on the expected output are analyzed and verified using experimental results.
Timo: In-Memory Temporal Query Processing for Big Temporal Data

We present Timo, a distributed in-memory temporal query and analytics model, to process mass intensive temporal data efficiently. Firstly, Timo implements a set of efficient execution processes for big temporal data. Secondly, a novel temporal index is suggested that has more efficiently query performance and less memory storage than the state-of-art methods. Thirdly, according to the temporal locality feature of temporal query, Timo suggests a partitioner mechanism, named FSpartitioner, which improves query throughput. Lastly, we deploy Timo system on Apache Spark platform, and experimental results show that Timo is superior to other Spark based temporal systems in respect of both query latency and throughput.
Chemical and Biological Characterization of the Anticancer Potency of Salvia fruticosa in a Model of Human Malignant Melanoma

Malignant melanoma is one of the most aggressive types of skin cancer with an increasing incidence worldwide. Thus, the development of innovative therapeutic approaches is of great importance. Salvia fruticosa (SF) is known for its anticancer properties and in this context, we aimed to investigate its potential anti-melanoma activity in an in vitro model of human malignant melanoma. Cytotoxicity was assessed through a colorimetric-based sulforhodamine-B (SRB) assay in primary malignant melanoma (A375), non-malignant melanoma epidermoid carcinoma (A431) and non-tumorigenic melanocyte neighbouring keratinocyte (HaCaT) cells. Among eight (8) different fractions of S. fruticosa extracts (SF1-SF8) tested, SF3 was found to possess significant cytotoxic activity against A375 cells, while A431 and HaCaT cells remained relatively resistant or exerted no cytotoxicity, respectively. In addition, the total phenolic (Folin–Ciocalteu assay) and total flavonoid content of SF extracts was estimated, whereas the antioxidant capacity was measured via the inhibition of tert-butyl hydroperoxide-induced lipid peroxidation and protein oxidation levels. Finally, apoptotic cell death was assessed by utilizing a commercially available kit for the activation of caspases - 3, - 8 and - 9. In conclusion, the anti-melanoma properties of SF3 involve the induction of both extrinsic and intrinsic apoptotic pathway(s), as evidenced by the increased activity levels of caspases - 8, and - 9, respectively.
Design and Realization of Multimobile Robot System With Docking Manipulator

This paper presents the design and realization of a multimobile robot system joint locomotion (JL)-2, which features not only a docking and 3D posture-adjusting capability between three robots but also a multifunctional docking gripper. By combining a parallel mechanism and a cam gripper together, this paper develops a docking manipulator, which endows each robot with a simple but forceful grasping capability. Furthermore, the docking manipulator can overcome the possible aligning errors between two robots and interconnect them. A motorized spherical joint will be formed between two docked robots, which will enhance the locomotion flexibility of the whole system. The docking mechanism is discussed in detail, including the docking procedure and analyses of self-aligning ability. A series of experiments not only testify the basic performances of JL-2 but also reveal the limits of current prototype, e.g., the overconstraint connecting pattern, the unbalanced self-aligning performance, etc.
A test bed for the evaluation of adaptive antennas used for mobile communications

This paper describes an advanced antenna test bed which will be used for mobile communications research. The test bed provides a common environment for testing advanced antennas and measurement data gathered in a realistic environment for evaluation of advanced antenna algorithms. The test bed was previously used to field test the five current personal communications services (PCS) technology standards in the United States. The test bed cells are described and a typical PCS field trail measurement is presented. A wideband measurement system developed for advanced antenna measurements is described. The system uses multiple mobile transmitters using maximal length pseudo random noise generators to modulate a radio frequency (RF) carrier. This provides a wideband signal for characterization of the radio channel. Central to the measurement methodology is the capability to characterize radio wave propagation simultaneously on each antenna element of an antenna array. A multichannel receiver employs IF digitization and raw data storage to maximize post-processing capabilities. Its features allow a random sampling of the radio channel suitable for mobile communications research. The receiver also has the capability to continuously stream data that is suitable for modeling and simulation studies of specific communication systems.
Vehicle Evasive Maneuver Trajectory Optimization Using Collocation Technique

Vehicle evasive maneuvers or sudden lane changes pose stringent conditions on trajectory control, which require not only a desired path following but also a complete consideration of lateral forces and vehicle dynamic stability. Experienced drivers steer the vehicle on a desired path, as much as possible, without creating large lateral forces beyond the stability limits. Steering control systems have been developed to perform similar lane change or evasive maneuvers automatically but with limitations. A control method is developed to find desired trajectory automatically based on the defined design criteria using constrained optimization via collocation technique. The results are compared with two known suitable trajectories. The results show that the proposed control method produces peak lateral acceleration that are lower than the 5th order polynomial trajectory, and overall lateral accelerations that are lower than a comparable trapezoidal acceleration profile. © 2010 ASME
Numerical Integration Procedure for the Steady State Navier-Stokes Equations:

A procedure is proposed for the integration of the full Navier-Stokes equations for constant-property two-dimensional flows. In contrast with earlier procedures, the present one is capable of dealing with cases of very high Reynolds number. The power of the new procedure is demonstrated in two cases: (1) the square recirculating eddy, for which no solution was previously available for Reynolds numbers larger than about 400, and (2) an impinging jet, for which no solution was available previously. The procedure has also been applied to the square cavity at Reynolds numbers below 400; it gives results of an accuracy comparable with that of previous solutions, but with a smaller computing time.
The P2Y12 Receptor Antagonist Selatogrel Dissolves Preformed Platelet Thrombi In Vivo

Selatogrel, a potent and reversible antagonist of the P2Y12 receptor, inhibited FeCl3-induced thrombosis in rats. Here, we report the anti-thrombotic effect of selatogrel after subcutaneous applications in guinea pigs and mice. Selatogrel inhibited platelet function only 10 min after subcutaneous application in mice. In addition, in a modified Folts thrombosis model in guinea pigs, selatogrel prevented a decrease in blood-flow, indicative of the inhibition of ongoing thrombosis, approximately 10 min after subcutaneous injection. Selatogrel fully normalised blood flow; therefore, we speculate that it may not only prevent, but also dissolve, platelet thrombi. Thrombus dissolution was investigated using real-time intravital microscopy in mice. The infusion of selatogrel during ongoing platelet thrombus formation stopped growth and induced the dissolution of the preformed platelet thrombus. In addition, platelet-rich thrombi were given 30 min to consolidate in vivo. The infusion of selatogrel dissolved the preformed and consolidated platelet thrombi. Dissolution was limited to the disintegration of the occluding part of the platelet thrombi, leaving small mural platelet aggregates to seal the blood vessel. Therefore, our experiments uncovered a novel advantage of selatogrel: the dissolution of pre-formed thrombi without the disintegration of haemostatic seals, suggesting a bipartite benefit of the early application of selatogrel in patients with acute thrombosis.
Safety risk assessment in industrial maintenance

Purpose – This paper aims to answer the following questions: What conditions must be taken into account in order to manage maintenance‐related risks? and how can the service‐providing company assess and manage maintenance‐related risks? Design/methodology/approach – The study was based on analyses concerning: maintenance‐related risks in companies; literature review; and real accident data. The development process was carried out in cooperation with companies providing maintenance services.Findings – Based on the findings, the method takes into account various risks relating to maintenance operations. The method includes specific parts for safety planning and hazard identification for managing maintenance safety. In addition, it provides a safety check‐list for the worker.Research limitations/implications – The usability and feasibility of the method should be reassessed and developed. The method could be especially useful in an electronic form.Practical implications – The method can be utilized for assess.
A simulation study to quantify the advantages of silicon-on-insulator (SOI) technology for low power

In this work, we combine the advantages of silicon-on-insulator (SOI) technology with asynchronous design techniques to assess the overall benefits in reducing power. A 16-bit self-timed adder is employed as the demonstrator circuit. At the technology level, fully-depleted SO1 offers advantages conpared with bulk CMOS. These arise due to lower subthreshold slope, lower vertical electric field hence enhanced channel mobility and reduced junction capacitance. The superior offstate current of SO1 enables the threshold voltage to be lowered enhancing the current drive properties of SO1 technology and enabling M e r power reduction without the loss of pe r fomce (1). At the architectural level of design, the adoption of asynchronous timing rather than a global clock reduces power. Here, the synchronous clock is replaced by local handshake signals between blocks. Although asynchronous control tends to be larger than in synchronous systems, significant power savings should result as the clock generation, drivers, and distribution are consuming around one third of the power in large, complex, high performance systems (2).
Design and Optimization of a Millimetre Wave Compact Folded Magic-T

A millimetre wave-folded magic-T junction compensated with metal cone is designed using a particle swarm optimization (PSO) algorithm. An off-centred metallic frustum was used to enhance the bandwidth and a metallic post is used to compensate the mismatched E-arm. The geometrical parameters of the frustum and the post are optimized by PSO. The optimized magic-T for W-band application is designed and tested. The design features are simple in structure and easy to fabricate. The 2% bandwidth with centre frequency of 94 GHz and return loss less than −20 dB is achieved.
Synchronicity and alignment of productivity: the real value from Service Science?

The ability of services to pervade all aspects of productivity creates the need for an interdisciplinary framework of service to be developed. It is, however, critical that any proposed service framework is jointly developed between the service purveyor and the stakeholders involved. An expected outcome from a focus on productivity in the Service Science arena is that a much closer relationship between the purveyor of a service and the customer is initiated and fostered. This requires a clear focus on the requirements of the customer and the various ways in which the service can be conveyed. This is not too far removed from what is required in other areas such as product specification that should also be carefully crafted from the needs of the customer. The research utilises two case studies to highlight the impact of Service Science as a co-producer of service productivity. We find from the case studies that human factors play an extremely important role in improving service productivity.