Miracle-dz/UniFAR-FTUs huggingface dataset:
Mobile Health Interventions for Cancer Care and Support: The Next Level of Digitalization in Healthcare?

Academic research has brought attention to the utility of mobile health (mHealth) interventions for assisting cancer patients and survivors in managing their medication, symptoms, and well-being. This is a vital research area, as cancer is the second main cause of death for the global populace. However, the knowledge on mHealth interventions for cancer is distinctly fragmented and there is a lack of clarity on its boundaries, which hinders identification of existing gaps and valuable areas in which to advance future research. Our study addresses this gap and provides a comprehensive review of extant literature to determine the core areas of discourse. This systematic literature review (SLR) amalgamates the extant findings related to users' (cancer patients, cancer survivors, healthcare providers, and clients) experiences of mHealth interventions. Following rigorous protocols, we reviewed pertinent literature from Scopus and Web of Science databases to curate 78 studies. Grounded theory was adopted as an analytical framework and content analysis was used to explicate state-of-the-art insights. To our knowledge, this is the most comprehensive SLR on this topic. The findings revealed four themes and incumbent gaps: (i) intervention targets and affordances, (ii) individual outcomes, (iii) methodological approaches, and (iv) intervention
Physics of Alfvén waves and energetic particles in burning plasmas

Dynamics of shear Alfven waves and energetic particles are crucial to the performance of burning fusion plasmas. This article reviews linear as well as nonlinear physics of shear Alfven waves and their self-consistent interaction with energetic particles in tokamak fusion devices. More specifically, the review on the linear physics deals with wave spectral properties and collective excitations by energetic particles via wave-particle resonances. The nonlinear physics deals with nonlinear wavewave interactions as well as nonlinear wave-energetic particle interactions. Both linear as well as nonlinear physics demonstrate the qualitatively important roles played by realistic equilibrium nonuniformities, magnetic field geometries, and the specific radial mode structures in determining the instability evolution, saturation, and, ultimately, energetic-particle transport. These topics are presented within a single unified theoretical framework, where experimental observations and numerical simulation results are referred to elucidate concepts and physics processes.
Identification of heart failure with preserved ejection fraction in patients with hypertension: a left atrial myocardial strain cardiac magnetic resonance study

Background The noninvasive diagnosis of heart failure with preserved ejection fraction (HFpEF) remains challenging. The role of left atrial (LA) functional changes in patients with HFpEF has attracted increased attention. This study aimed to evaluate LA deformation in patients with hypertension (HTN) using cardiac magnetic resonance tissue tracking and to investigate the diagnostic value of LA strain for HFpEF. Methods This retrospective study consecutively enrolled 24 HTN patients with HFpEF (HTN-HFpEF) and 30 patients with pure HTN based on clinical indications. Thirty age-matched healthy participants were also enrolled. All participants underwent a laboratory examination and 3.0 T cardiovascular magnetic resonance (CMR). The LA strain and strain rate, including total strain (εs), passive strain (εe), active strain (εa), peak positive strain rate (SRs), peak early negative strain rate (SRe), and peak late negative strain rate (SRa), were evaluated using CMR tissue tracking and compared among the 3 groups. Receiver operating characteristic (ROC) analysis was used to identify HFpEF. Spearman correlation was used to analyze the correlation between LA strain and brain natriuretic peptide (BNP) level. Results Patients with HTN-HFpEF had significantly lower εs (17.70%, IQR 14.65% to 19.70%, εe 7.83%±2.86%), εa (9.08%±3.19%), SRs (0.88±0.24 s−1), SRe (−0.60 s−1, IQR −0.90 to −0.50 s−1), and SRa (−1.10±0.47 s−1) than did patients with HTN and control participants (all P values <0.05). Compared to the control group, patients with HTN had lower εs (25.35%, IQR 21.80% to 27.25%), εe (11.49%±2.64%), SRs (1.10 s−1, IQR 1.00 to 1.48 s−1), and SRe (−1.11±0.37 s−1) (all P values <0.05). The values of εa and SRa were not significantly different between the HTN and control groups. LA total strain εs was independently associated with HFpEF (odds ratio 0.009; P<0.05) with a cutoff value of 19.55% (95% CI: 0.882–0.996), and the sensitivity and specificity were 75% and 97%, respectively. There was a good correlation between the LA strain parameters and BNP level (all P values <0.05). Conclusions LA function impairment exists in patients with HFpEF. The LA strain parameter has potential value in diagnosing HFpEF.
Atrial fibrillation detection using Poincare geometry and heart beat intervals

Detection of atrial fibrillation (AF) remains one of the major concerns in the field of medical research. AF is one of the main cause for stroke. AF is characterized by irregular heartbeats and absence of P waves in electrocardiogram (ECG) signal. In this article, we propose a method, combining Poincare plot derived and RR interval‐based features to classify given ECG signal into normal, AF and other rhythms. Classification and regression tree, K‐nearest neighbor, support vector machine, artificial neural network, ResNet18, convolutional neural network (CNN)‐long short term memory (LSTM) are implemented for classification of ECG signal. The class specific accuracies for the three rhythms are computed. Physionet challenge 2017 database is used for evaluation and testing of the developed algorithm. The database has 5154 normal, 771 AF, 2557 other rhythm and 46 noisy signals. Three Poincare derived features viz: SD1, SD2, and ratio of SD1 to SD2, three RR interval features viz: Mean stepping increment of RR interval, approximate entropy and sample entropy are computed and are given to classifiers. During fivefold cross‐validation, CNN‐LSTM classifier showed best result with class specific accuracy for normal of 96.65%, AF of 97.55%, other rhythms of 94.87%, overall accuracy of 96.17% and F1 score of 0.9589. The developed technique can bring change in conventional practice in AF diagnosis and can aid the physician as an assisted tool.
Quantitative Phosphoproteomics Reveals the Requirement of DYRK1-Mediated Phosphorylation of Ion Transport- and Cell Junction-Related Proteins for Notochord Lumenogenesis in Ascidian

The dual-specificity tyrosine phosphorylation-regulated kinase (DYRK1) phosphorylates diverse substrates involved in various cellular processes. Here, we found that blocking the kinase activity of DYRK1 inhibited notochord development and lumenogenesis in ascidian Ciona savignyi. By performing phosphoproteomics in conjunction with notochord-specific proteomics, we identified 1065 notochord-specific phosphoproteins that were present during lumen inflation, of which 428 differentially phosphorylated proteins (DPPs) were identified after inhibition of DYRK1 kinase activity. These DPPs were significantly enriched in metal ion transmembrane transporter activity, protein transport and localization, and tight junction. We next analyzed the downregulated phosphoproteins and focused on those belonging to the solute carrier (SLC), Ras-related protein (RAB), and tight junction protein (TJP) families. In vivo phospho-deficient study showed that alanine mutations on the phosphosites of these proteins resulted in defects of lumenogenesis during Ciona notochord development, demonstrating the crucial roles of phosphorylation of transmembrane transport-, vesicle trafficking-, and tight junction-related proteins in lumen formation. Overall, our study provides a valuable data resource for investigating notochord lumenogenesis and uncovers the molecular mechanisms of DYRK1-mediated notochord development and lumen inflation.
Unstationary control of a launcher using observer-based structures

This paper deals with the design of a gain-scheduled controller for the attitude control of a launcher during atmospheric flight. The design is characterized by classical requirements such as phase/gain margins and flexible mode attenuations as well as time-domain constraints on the response of angle of attack to a worst-case wind profile. Moreover, these requirements must be fulfilled over the full atmospheric flight envelope and must be robust against parametric uncertainties. In order to achieve this goal, we propose a method based on minimal observer-based realizations of arbitrary stabilizing compensators. An original technique to assign the closed-loop dynamics between the state-feedback dynamics and the state-estimation dynamics is presented for the H/sub /spl infin// compensators case. The structure is used to mix various specifications through the cross standard form (CSF) and to perform a smooth gain scheduling interpolation through an Euler-Newton algorithm of continuation.
A Pain That is Easily Overlooked: Referred Pain Caused by OVCF

Purpose The objective of this study was to analyze the clinical characteristics and the therapeutic effects of treatment at our spinal center in OVCF patients associated with referred pain. The underlying goals were to deepen the understanding of referred pain caused by OVCFs, improve the currently low early diagnosis rate of OVCFs, and improve the effectiveness of treatment. Methods The patients who had referred pain from OVCFs and met the inclusion criteria were retrospectively analyzed. All patients were treated with percutaneous kyphoplasty (PKP). Visual analog scale (VAS) scores and Oswestry Disability Index (ODI) were used to evaluate the therapeutic effect at different time points. Results There were 11 males (19.6%) and 45 females (80.4%). Their corresponding mean bone mineral density (BMD) value was −3.3 ± 0.4. The regression coefficient of BMD in the linear regression equation was −4.51 (P<0.001). According to the classification system for referred pain in OVCFs, there were 27 cases of type A (48.2%), 12 cases of type B (21.2%), 8 cases of type C (14.3%), 3 cases of type D (5.4%), and 6 cases of type E (10.7%). All patients were followed up for at least 6 months, and both VAS scores and ODI were found to be significantly better postoperatively than preoperatively (P<0.001). There was no significant difference in VAS scores and ODI between different types preoperatively or 6 months postoperatively (P > 0.05). Within each type, there were significant differences in VAS scores and ODI between the pre- and postoperative timepoints (P < 0.05). Conclusion Attention should be paid to referred pain in OVCF patients, which is not uncommon in clinical practice. Our summary of the characteristics of referred pain caused by OVCFs can improve the early diagnosis rate of OVCFs patients and provide a reference for their prognosis after PKP.
Random error modelling and compensation of accelerometer in airborne remote sensing stabilized platform

This paper studies the impact of the accelerometer output error on the levelling accuracy in levelling mode of the airborne remote sensing stabilized platform. On the basis that the accelerometer output signal is non-stationary, a non-stationary time series model of ARIMA(3,0,1) is established, with which an adaptive Kalman filter is designed. In the Kalman filter, an online correction method for the forgetting factor based on real-time measurements is presented, achieving the automatic adjustment of the Kalman filter gain. The model of the accelerometer and the adaptive Kalman filter are applied to the airborne remote sensing stabilized platform principle prototype made by our research group. On one hand, the results show that the model is fit for the accelerometer. On the other hand, it is noted that the new filter has improved the measurement accuracy of the accelerometer, depressed the oscillations of the levelling progress of the platform and reduced the steady-state error of the platform. The levelling performance of the stabilized platform is efficiently improved after all these work.
Relativistic effects : applications to multiferroic materials

We studied the physics of materials where relativistic effects are important. We first coupled the semi-relativistic Hamiltonian with the Maxwell's equations, and derived the current and density sources, which included second-order terms like the spin and Darwin polarizations. Different models were developed, by expanding the Maxwell's equations. We then performed ab initio studies to explain (1) site disorders as the origin of ferrimagnetism in multiferroic GaFeO3 (GFO), (2) crystal-field theory where the Fe 3d states at the deformed octahedra have tetrahedral splittings, (3) the electric polarization as a function of temperature, and (4) the insufficiency of the direct magnetoelectric (ME) mechanism to explain observed ME behavior. For Cr2O3, bulk calculations for different biaxial strains failed to explain its ferromagnetism, indicating that size or excess-O effects might be important. Finally, we implemented XAS and XMCD in VASP and computed these spectra for GFO.
Analytical Approximate Solutions of Stochastic Models Arising in Statistical Systems and Financial Markets

Homotopy Perturbation Method (HPM) is applied to solve stochastic models and in the simialr context Fokker-Planck equation for non-equilibrium statistical systems and Black-Scholes model for pricing stock options are tackled The analytical solutions are calculated in the form of convergent power series. The results reveal that HPM is very effective and convenient for stochastic models.
On non-singular Markov renewal processes with an application to a growth–catastrophe model

The paper is concerned with Markov renewal processes satisfying a certain non-singularity condition. The relation of this condition to irreducibility, Harris recurrence and regularity of the associated forward Markov process is studied. This enables one to prove limit theorems of a total variation type for Markov renewal processes and semi-regenerative processes by applying Orey's theorem to the forward process. The results are applied to a GI/G/1 queue and a growth-catastrophe population model.
Prevalence of Hypertension and Associated Co-Morbidities in Pakistan

Background: Hypertension is one of the major chronic health problems found amongst the vast population of the World. Hypothesis: According to WHO, it is the 10th leading cause of death, and global data indicates that nearly 17 million deaths occur annually due to cardiovascular diseases, amongst which hypertension accounts for more than 7 million. Methods: Its prevalence has been seen most in black people. According to previous studies conducted in all four provinces of Pakistan, hypertension has now become the leading chronic disease affecting not only adults but also children, not only the urban but also the rural population. Result: Its incidence is increasing day by day. In more than 90% of the cases, the exact cause of hypertension is unknown, but certain predisposing factors may contribute to this disease such as excessive use of salt in diet, increased blood cholesterol, obesity, alcohol, smoking, lack of exercise and stress. It is more common in urban than rural populations. Hypertension is the most common risk factor for both cardiovascular diseases and stroke. It may also cause renal impairment and hypertensive retinopathy. If it remains uncontrolled for a long time, then it may cause death. Conclusion: This review is an update regarding the prevalence of hypertension and associated co-morbidities in Pakistan
Exploratory Analysis of Patients With Gastric/Gastroesophageal Junction Adenocarcinoma With or Without Liver Metastasis From the Phase 3 RAINBOW Study

Purpose Liver metastasis (LM) is reported in approximately 40% of patients with advanced/metastatic gastric/gastroesophageal junction adenocarcinoma (metastatic esophagogastric adenocarcinoma; mGEA) and is associated with a worse prognosis. This post-hoc analysis from the RAINBOW trial reported the efficacy, safety, and biomarker outcomes of ramucirumab and paclitaxel combination treatment (RAM+PAC) in patients with (LM+) and without (LM−) LM at baseline. Materials and Methods Patients (n=665) were randomly assigned on a 1:1 basis to receive either RAM+PAC (LM+: 150, LM−: 180) or placebo and paclitaxel (PL+PAC) (LM+: 138, LM−: 197). The overall survival (OS) and progression-free survival (PFS) were evaluated using stratified Kaplan–Meier and Cox regression models. The correlation of dichotomized biomarkers (VEGF-C, D; VEGFR-1,2) with efficacy in the LM+ versus LM− subgroups was analyzed using the Cox regression model with reported interaction P-values. Results The presence of LM was associated with earlier progression than those without LM, particularly in patients receiving PL+PAC (hazard ratio [HR], 1.68). RAM+PAC treatment improved OS and PFS irrespective of LM status but showed greater improvement in LM+ than that in LM− (OS HR, 0.71 [LM+] vs. 0.88 [LM−]; PFS HR, 0.47 [LM+] vs. 0.76 [LM−]). Treatment-emergent adverse events were similar between patients with and without LM. No predictive relationship was observed between biomarker levels (VEGF-C, D; VEGFR-1,2) and efficacy outcome (OS, PFS) (all interaction P-values >0.05). Conclusions RAM provided a significant benefit, irrespective of LM status; however, its effect was numerically stronger in patients with LM. Therefore, RAM+PAC is a clinically meaningful therapeutic option for patients with mGEA and LM. Trial Registration ClinicalTrials.gov Identifier: NCT01170663
The Nulling Stellar Coronagraph: Laboratory Tests and Performance Evaluation

The nulling coronagraph, first proposed by Roddier and Roddier, uses a small mask (less than half the size of the central Airy spot) that shifts the phase of the incoming light by 180° to strongly attenuate the Airy spot as well as the rings. We report on both theoretical and laboratory performance. In our laboratory experiment, we reduce the peak intensity of the Airy pattern by a factor of 16. We derive estimates of the performance of a nulling coronagraph used on a telescope equipped with an adaptive optics system, based upon the performance of the University of Hawaii Hokupa’a adaptive optics system. On a 3.6 m telescope at 1.65 μm, it is found that a tip/tilt amplitude lower than 20 mas is needed for such a coronagraph to yield an extinction better than 2 stellar mag.
Experimental Studies of Flow Separation of the NACA 2412 Airfoil at Low Speeds

Wind tunnel tests have been conducted on an NACA 2412 airfoil section at Reynolds number of 2.2 x 10(exp 6) and Mach number of 0.13. Detailed measurements of flow fields associated with turbulent boundary layers have been obtained at angles of attack of 12.4 degrees, 14.4 degrees, and 16.4 degrees. Pre- and post-separated velocity and pressure survey results over the airfoil and in the associated wake are presented. Extensive force, pressure, tuft survey, hot-film survey, local skin friction, and boundary layer data are also included. Pressure distributions and separation point locations show good agreement with theory for the two layer angles of attack. Boundary layer displacement thickness, momentum thickness, and shape factor agree well with theory up to the point of separation. There is considerable disparity between extent of flow reversal in the wake as measured by pressure and hot-film probes. The difference is attributed to the intermittent nature of the flow reversal.
Terminology and ontology development for semantic annotation: A use case on sepsis and adverse events

Annotations enrich text corpora and provide necessary labels for natural language processing studies. To reason and infer underlying implicit knowledge captured by labels, an ontology is needed to provide a semantically annotated corpus with structured domain knowledge. Utilizing a corpus of adverse event documents annotated for sepsis-related signs and symptoms as a use case, this paper details how a terminology and corresponding ontology were developed. The Annotated Adverse Event NOte TErminology (AAENOTE) represents annotated documents and assists annotators in annotating text. In contrast, the complementary Catheter Infection Indications Ontology (CIIO) is intended for clinician use and captures domain knowledge needed to reason and infer implicit information from data. The approach taken makes ontology development understandable and accessible to domain experts without formal ontology training.
New technique for reducing cogging torque in a class of brushless DC motors

It is shown that the cogging torque in permanent magnet and brushless DC motors, where the number of magnet poles is close to the number of armature slots, can be reduced considerably by adjusting the width of the poles or the width of the slots. A design method to achieve this goal is presented. The influence of the slot opening on the cogging torque is thoroughly investigated theoretically and experimentally for a prototype. >
A Parkes radio telescope study of giant pulses from PSR J1823-3021A

We report on 685-MHz observations of PSR J1823-3021A using the Parkes radio telescope. A total of 120 giant pulses (GPs) were found by searching for spiky emission at 16-(is time resolution. The energies of these pulses follow a power law that has a very steep exponent of -3.1. This means that the emission mechanism that gives rise to the GPs almost always produces pulses that only have moderate energies. The profile formed by adding all the GPs has components that are narrower and more widely separated than the profile formed from all pulses. Aberration and retardation of emission from a corotating volume mean that components emitted at high altitude will have asymmetric phases compared to those emitted at low altitude. By assuming that the components of the pulse profile form conal pairs, we use this effect to limit the GPs to be emitted no higher than 4 km above ordinary emission. The arrival times of the GPs are well modelled by Poisson statistics at time-scales around 100 s. We report a GP with spikes of emission at the phases of both components. The probability of two independent GPs occurring within a single pulse period is O(10 -4 ), so an interpretation can be conjectured that the two pulses are not independent. This may mean that the magnetosphere can remain in a state that is susceptible to discrete 'giant' emission events for as long as 2 ms.
The correlation function of rich clusters of galaxies: a comparison of APM and Abell clusters

From an analysis of a new redshift survey of nearby Abell clusters, Postman et al. (1992, ApJ, 384) find that the spatial correlation function of R ≥ 0 Abell clusters is well described by a power law ξ cc (S) = (r 0 /S) 1.8 with r 0 ∼ 20 h -1 Mpc, a result which is apparently discrepant with the lower amplitude, r 0 ∼ 13 h -1 Mpc, found in our analysis of rich clusters selected from the APM Galaxy Survey. Here, Postman et al.'s data are used to show that the clustering of Abell clusters is highly anisotropic in redshift space, providing clear evidence of artificial clustering
Multivariate location estimation using extension of R-estimates through U-statistics type approach

We consider a class of U-statistics type estimates for multivariate location. The estimates extend some R-estimates to multivariate data. In particular, the class of estimates includes the multivariate median considered by Gini and Galvani (1929) and Haldane (1948) and a multivariate extension of the well-known Hodges-Lehmann (1963) estimate. We explore large sample behavior of these estimates by deriving a Bahadur type representation for them. In the process of developing these asymptotic results, we observe some interesting phenomena that closely resemble the famous shrinkage phenomenon observed by Stein (1956) in high dimensions. Interestingly, the phenomena that we observe here occur even in dimension d = 2.