Miracle-dz/UniFAR-FTUs huggingface dataset:
Polygonum cuspidatum Extract Exerts Antihyperlipidemic Effects by Regulation of PI3K/AKT/FOXO3 Signaling Pathway

Polygonum cuspidatum (PC) has been reported to exert a potent antihyperlipidemic effect. However, its mechanisms of action and active ingredients remain elusive and require further research. In this study, we first conducted in vivo experiments to validate that Polygonum cuspidatum extract (PCE) could ameliorate the blood lipid level in hyperlipidemia model rats. Then, ultrahigh performance liquid chromatography coupled with Q-Exactive MS/MS (UPLC-QE-MS/MS) was applied to verify its 12 main active ingredients. The pharmacophore matching model was employed to predict the target point of the active ingredient, and 27 overlapping genes were identified via database and literature mining. String online database and Cytoscape software were utilized to construct a Protein-Protein Interaction (PPI) network, followed by function annotation analysis and pathway enrichment analysis. The results showed that the PI3K/AKT signaling pathway and its downstream FOXO3/ERα factors were significantly enriched. Furthermore, in vitro experiments were performed to determine the lipid content and oxidative stress (OS) indicators in OA-induced HepG2 cells, and immunofluorescence and western blotting analysis were carried out to analyze the effects of PCE on related proteins. Our experimental results show that the mechanism of antihyperlipidemic action of PCE is related to the activation of the PI3K/AKT signaling pathway and its downstream FOXO3/ERα factors, and polydatin and resveratrol are the main active ingredients in PCE that exert antihyperlipidemic effects.
Generation of optical frequency combs based on time-to-frequency conversion

Flat-top optical frequency combs (OFC) are generated using electro-optical phase modulators (PM) driven by sinusoidal signals as a time-to-frequency convertor. A linear equation is derived to predict the number of OFC lines according to the time duration of the flat-top pulse inputted to the PM and the modulation index of the PM. Both the simulated and experimental results confirm the validity of the proposed method.
In vitro cytotoxicity and genotoxicity of single and combined pesticides used by Bolivian farmers

We previously showed that farmers in Bolivia are exposed to many pesticides, some at elevated levels, and that this was associated with increased risk of genetic damage. To improve the understanding of possible mixture effects, the cytotoxicity and genotoxicity of pesticides were studied in vitro using human liver HepG2 cells. The studied pesticides were 2,4‐D, chlorpyrifos, cypermethrin, glyphosate, methamidophos, paraquat, profenofos, and tebuconazole. Three mixtures (U1, U2, and U3) were based on profiles of urinary pesticide metabolites and one mixture on the most frequently used pesticides (S1). The results showed that paraquat and methamidophos were the most cytotoxic pesticides (EC50 ≤0.3 mM). Paraquat, chlorpyrifos, tebuconazole, and the U1, U2, and U3 mixtures, which contained a large proportion of either chlorpyrifos or tebuconazole, significantly increased intracellular ROS levels. Most pesticides activated DNA damage signaling through proteins Chk1 and H2AX. Strongest responses were elicited by paraquat, profenofos, chlorpyrifos, cypermethrin, and the S1 mixture, which contained 25% paraquat. Comet assay revealed significant increases of DNA damage in response to paraquat, cypermethrin, and U2 and S1 mixtures, which contained high levels of cypermethrin and paraquat, respectively. In summary, we showed that the tested pesticides, alone or in mixtures, in general induced oxidative stress and that most pesticides, and especially paraquat and cypermethrin, were genotoxic in HepG2 cells. We could also show that mixtures dominated by these two pesticides displayed a marked genotoxic potency, which agreed with our previous population studies.
The study of electronic voltage transducers operation in conditions of dips and interruptions of measured voltage

The aim of the paper is to present a response on dips and on interruptions of the measured voltage by means of electronic voltage transducers and inductive voltage transformers. Results of laboratory studies show high overvoltages generated in both a primary and secondary side of inductive VTs during the above mentioned conditions. Overvoltages in secondary circuits may damage measuring or protection apparatus connected to the secondary side of the VT. Using electronic voltage transducers enables users to avoid these problems.
UNDERSTANDING THE NATURE OF PARTICIPATION & COORDINATION IN OPEN AND GATED SOURCE SOFTWARE DEVELOPMENT COMMUNITIES.

This article focuses on two questions related to community-based product development: why do participants voluntarily work within and contribute to communities that provide, support, and maintain a public good, and how to large numbers of participants coordinate their work efforts? The article states that main reasons why an individual might participate in a product development community are enjoyment and a need for software. The article discusses the importance of a variety of users and developers, and communication between them, and states that limiting a participant's ability to alter code will result in a decrease in participation.
A survey on anonymous ip address blocking

These days, the Internet is full of suspicious actions and people. We always advise to not take a chance in protecting your IP Address information online. TheIP was being shown everywhere! To advertisersandother places ,even from SPAM who compromised usersidentity. No more I said, and developed software that would hide ip address.we outline a security protocol that uses resource constrained trusted hardware to facilitate anonymous IP-address blocking in anonym zing networks such as Tor. Tor allows users to access Internet services privately by using a series of Tor routers to obfuscate the route from the client to the server, thereby hiding the client’s IP address from the server. The success of Tor, however, has been limited because of malicious users who misuse the network. administrators block all known exit nodes of anonymizing networks, denying nonymous access to misbehaving and behaving users alike. To address this problem, we present Nymble, a system in which servers can ―blacklist‖ misbehaving users, thereby blocking users without compromising their anonymity. Our system is thus agnostic to different servers’ definitions of misbehavior servers can blacklist users for whatever reason, and the privacy of blacklisted users is maintained. The IP-address anonymity provided by Tor, however, makes it difficult for administrators to deny access to such offenders . As a result, administrators resort to blocking all Tor exit nodes, effectively denying anonymous access for all Tor’s users. Our solution makes use of trusted hardware and allows services like Tor to provide anonymous blocking of IP addresses while requiring only a modest amount of storage at the trusted node. Key terms: IP , pockets, NYMBLE,Anonymizing networks, privacy.
Opiate Use After Endoscopic Endonasal Transsphenoidal Surgery

Background The literature on opiate use after endoscopic endonasal transsphenoidal surgery (EETS) is limited. Objective To determine the risk factors for higher opiate use following EETS and the quantity of opiates used after discharge. Methods A retrospective review of 144 patients undergoing EETS from July 2018 to July 2020 was conducted. Patient, tumor, and surgical factors were documented. Pain scores and medications used on postoperative days (POD) 0 and 1, and discharge prescriptions, were recorded. Opiate use was quantified using morphine milligram equivalents (MME) dose. Multiple linear regression determined risk factors independently associated with POD0 to 1 opiate use. Results On POD 0 to 1, mean pain score was 4.9/10 (standard deviation [SD] ± 2.0). Mean acetaminophen use was 3.4 tablets (SD ± 1.6; 650 mg per tablet). Mean opiate use was 35.6 MME (SD ± 36.3), equivalent to 4.7 tablets (SD ± 4.8) of oxycodone 5 mg. Multiple linear regression showed that current smokers required an additional 37.1 MME (P = .011), and patients with grade 3 intraoperative cerebrospinal fluid leaks required an additional 36.7 MME (P = .046) on POD0 to 1. On discharge, mean opiate prescription was 117.7 MME (SD ± 102.1), equivalent to 15.7 tablets (SD ± 13.6) of oxycodone 5 mg. Thirty-nine patients (27.1%) did not require prescriptions. Only 10 patients (6.9%) required opiate refill(s) within 30 days after surgery. Conclusion Patients undergoing EETS have higher opiate needs compared to those undergoing endoscopic sinus surgery, although the overall requirements are still considered low. Independent risk factors associated with higher opiate use in the immediate postoperative period included current smokers and grade 3 intraoperative cerebrospinal fluid leaks.
Analyses of Arrow Air DC-8-63 accident of December 12, 1985 - Gander, Newfoundland

A performance analysis was conducted of the Arrow Air DC-8-63 takeoff accident at 10:15 GMT, December 12, 1985 at Gander, Newfoundland. A two-part study was conducted. A takeoff sensitivity analysis was performed using a digital, fixed stick simulation program to establish the relative performance degradation resulting from several factors that were candidate causes or contributing factors to the accident. The second approach was to reconstruct the accident trajectory by solving the airplane equations of motion using flight recorder data and known accident facts supplied by the Canadian Aviation Safety Board (CASB) as input. Consistent results were achieved from the two approaches.
Cable and accessory installation

This paper emphasises the care necessary to ensure a satisfactory XLPE power cable installation capable of giving a service life at least equal to that of paper cable. Some of the precautions taken during installation and the sophistication of the environment and techniques used may seem more than might be expected, especially compared to the humble low voltage origins of polymeric cable. It is however the case that if you reduce the engineering specification then inevitably you put the service reliability at risk. Such risks become less acceptable as system voltages and conductor sizes rise, because of the reduced factors of safety and the higher electrical and thermomechanical performance requirements. (5 pages)
Potato bacterial ring rot pathogen detection and outbreak prevention

This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC) (http:// creativecommons.org/licenses/by-nc/4.0/), which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes. For commercial reuse, contact reprints@pulsus.com REVIEW ARTICLE
Adaptive crosshatch approach for the laminated object manufacturing (LOM) process

The waste material removal process of laminated object manufacturing (LOM), so-called 'decubing', is a labour-intensive and time-consuming work resulting from the commonly used uniform crosshatch setting. An adaptive crosshatch approach to improve working efficiency and alleviate the effort involved in the decubing process is developed. The working region is divided into two portions, the inner region and the outer region, by the proposed rectangle and original contour offset approaches. The fine crosshatch pattern is designated to the inner region based on the shape of the cross-section contour, and the rules to select crosshatches for different shapes are given. The outer region has a coarse crosshatch pattern, and it is an integer multiple of that of the inner region. The brick-layered effect in the overlap zone of the waste material is eliminated by the projection method. Experiments show that with the adaptive crosshatch approach there are four major advantages: saving laser power consumption, protecting the part from damage, improving machining efficiency and easier decubing.
Effect and Improvement Areas for Port State Control Inspections to Decrease the Probability of Casualty

textabstractThis report is the fourth part of a PhD project called "The Econometrics of Maritime Safety – Recommendations to Enhance Safety at Sea" and is based on 183,000 port state control inspections and 11,700 casualties from various data sources. Its overall objective is to provide recommendations to improve safety at sea. The fourth part looks into measuring the effect of inspections on the probability of casualty on either seriousness or casualty first event to show the differences across the regimes. It further gives a link of casualties that were found during inspections with either the seriousness of casualties and casualty first events which reveals three areas of improvement possibilities to potentially decrease the probability of a casualty – the ISM code, machinery and equipment and ship and cargo operations.
Isolation and Identification of Microorganisms Involved in the Spoilage of Pawpaw Fruit (Carica papaya) Enugu Metropolis, Nigeria. Ugwuanyi R.C., Chibuzor C.A. and Onah G.T

This project work was carried out to isolate and identify the microorganisms involved in the spoilage of pawpaw fruit (Carica papaya). Microorganisms associated with spoilage of the fruit were studied using standard microbiological method. The serial dilution method was employed using nutrient agar, Mac Ctonkey agar, CLED agar and Sabouraud dextrose agar. A total number of 10 samples of spoilt pawpaw fruits (Carica papaya) were examined by culturing them on nutrient agar, CLED agar and MacConkey agar for bacteria and sabouraud agar for fungi. The bacterial isolates were Escherichia coli (27.6%) which had the highest occurrence, Enterobacter spp. (24.4%), Staphylococcus aureus (29.6%) with Pseudomonas(18.6%) having the least occurrence . The fungal isolates obtained were Aspergillus niger, Aspergillus flavus and Fusarium spp. The fungal and bacterial loads were high enough to cause food spoilage or food infection. The presence of the isolates may be due to improper hygienic practices from the point of harvesting, transportation and storage by handlers. Above all, the high moisture content of pawpaw fruit (Carica papaya) makes it highly perishable as its supports the growth of microorganisms.
A quantative approach to estimate the life expectancy of motor insulation systems

Electric motors represent the largest single load in most power systems. With continuing increase in nonlinear loads, the effects of harmonic contents of power systems on various components is becoming more important. This paper is concerned with the effects of power system harmonics and voltage unbalance on the useful life of electric motors. A simple equivalent circuit is used to calculate the additional heat losses caused by supply distortions. A lumped-parameter thermal network is proposed to calculate the resulting heat distribution within the machine. An Arrhenius chart is then used to estimate motor insulation remaining life. The proposed approach is used to determine the effect of supply harmonics and voltage unbalance on the useful life of a three phase induction motor and the results are verified experimentally.
The effect of crowding on public transit user travel behavior in a large-scale public transportation system through modeling daily variations

In this paper, the crowding effect in a transit vehicle is modeled in a time-expanded network that considers the daily variation in passenger flows. The study models the daily variation of in-vehicle crowding in a real large-scale transit system. A transit assignment for this real network is modeled and implemented by constructing a crowding cost function that follows the valuation of crowding and by using the reliable shortest path finding method. The direct application of the crowding model to a real network for the Utah Transit Authority indicates that crowd modeling with multi-user classes could influence public transportation system planning and affect the revenues of transit agencies. Moreover, the addition of the disutility factor, crowding, does not always appear to cause an increase in disutility for transit users.
Load Side Management Using Solar Power System: A Review

The objective of the present work is to review the solar-based power generation system, which can be used as stand-alone or grid-connected systems. The main goal of the proposed work is to find out demand site management used for domestic households. This work presents an in-depth review to determine how to achieve DSM through advanced metering infrastructure (AMI) and solar photovoltaic (PV) integration on domestic power distribution systems.
MAGNet: A Camou�age Object Detection Network Simulating The Observation Effect of Magni�er

In recent years, protecting important objects by simulating animal camou�age has been widely used in many �elds. Therefore, the Camou�aged Object Detection (COD) technology has emerged. COD is more di�cult than traditional target detection techniques because of the high degree of fusion of camou�aged objects with the background. In this paper, we strive to identify camou�aged objects more accurately. Inspired by humans using a magni�er to search for hidden objects in pictures, we propose a COD network that simulates the observation effect of a magni�er, termed Magni�er Network (MAGNet). Speci�cally, our MAGNet contains two parallel modules, i.e., Ergodic Magnify module (EMM) and Attention Focus module (AFM). The EMM is designed to mimic the magnifying process of a magni�er ergodicing an image, and the AFM is used to perform the observation process in which human attention is highly focused for focusing on a region. The two sets output camou�aged object maps are merged to achieve the effect of simulating the observation of the object by a magni�er. Extensive experiments demonstrate that compared with 14 cutting-edge detection models, the MAGNet can achieve the best comprehensive effect of 8 evaluation indicators on the public COD dataset, and the segmentation accuracy is signi�cantly improved.
A Continuous Mapping For Augmentation Design

Automated data augmentation (ADA) techniques have played an important role in boosting the performance of deep models. Such techniques mostly aim to optimize a parameterized distribution over a discrete augmentation space. Thus, are restricted by the discretization of the search space which normally is handcrafted. To overcome the limitations, we take the ﬁrst step to constructing a continuous mapping from R d to image transformations (an augmentation space). Using this mapping, we take a novel approach where 1) we pose the ADA as a continuous optimization problem over the parameters of the augmentation distribution; and 2) use Stochastic Gradient Langevin Dynamics to learn and sample augmentations. This allows us to potentially explore the space of inﬁnitely many possible augmen-tations, which otherwise was not possible due to the discretization of the space. This view of ADA is radically different from the standard discretization based view of ADA , and it opens avenues for utilizing the vast efﬁcient gradient-based algorithms available for continuous optimization problems. Results over multiple benchmarks demonstrate the efﬁciency improvement of this work compared with previous methods.
Toxicological evaluation of Aqueous Extract of Ocimum gratissimum on Liver and Kidney of Testosterone and Estradiol induced Benign Prostatic Hyperplasia in Adult Male Rats

Benign prostatic hyperplasia (BPH) is a noncancerous enlargement of the prostate gland. The condition is associated with symptoms like frequency in urination, hesitancy, nocturia, weak urine stream and sexual dysfunction. The effect of Ocimum gratissimum extract (OG) on kidney and liver function indices in BPH was investigated. A total of 30 rats weighing 200-300 g were divided according to body weight into five groups (n=6). One group was used as a control and the other groups received subcutaneous injections of testosterone and estradiol for 3 weeks to induce BPH. Groups I and II were treated with different doses of VA extracts and group III received finasteride, all by gavaging for thirty-five days. While group IV was left untreated, group V served as normal control. After thirty-five days of treatment with OG extract, the rats were anaesthetised by short contact with trichloromethane vapour. Blood was collected by cardiac puncture and the sera centrifuged and used for the determination of various different biochemical indices. The prostates were harvested and weighed. The levels of urea and creatinine in the treated groups were significantly (P<0.05) reduced when compared with to the BPH control. No significant (P>0.05) differences in serum concentrations of AST, ALT, ALP, and GGT were observed in all the treated groups compared to the BPH control. The extract of Ocimum gratissimum leaf demonstrated the potential to reverse the damage caused by BPH on the kidney. There were no noticeable changes recorded in the levels of liver enzymes indicating that Ocimum gratissimum had no toxicological effect on the liver. Likewise, BPH condition has no sequela effect on the liver.
Generalizable Imitation Learning from Observation via Inferring Goal Proximity

Task progress is intuitive and readily available task information that can guide an agent closer to the desired goal. Furthermore, a task progress estimator can generalize to new situations. From this intuition, we propose a simple yet effective imitation learning from observation method for a goal-directed task using a learned goal proximity function as a task progress estimator for better generalization to unseen states and goals. We obtain this goal proximity function from expert demonstrations and online agent experience, and then use the learned goal proximity as a dense reward for policy training. We demonstrate that our proposed method can robustly generalize compared to prior imitation learning methods on a set of goal-directed tasks in navigation, locomotion, and robotic manipulation, even with demonstrations that cover only a part of the states.
PARAMETRIC OPTIMIZATION OF MIG PROCESS PARAMETERS USING TAGUCHI AND GREY TAGUCHI ANALYSIS

The aim of this study is to investigate the optimization process parameters for Metal inert gas welding (MIG). The optimization of MIG welding operating parameters are for alloy steel work piece using grey relational analysis method. Sixteen experimental runs based on an orthogonal array Taguchi method were performed. This paper presents the influence of welding parameters like wire diameter, welding current, arc voltage, welding speed, and gas flow rate optimization based on bead geometry of welding joint. The objective function have been chosen in relation to parameters of MIG welding bead geometry Tensile strength, Bead width, Bead height, Penetration and Heat affected zone (HAZ) for quality target. Optimal parameters contribution of the MIG operation was obtained via grey relational analysis. By analysis the grey relational grade, preprocessed data, and grey relational coefficient of grey relational controllable process factor on the individual quality characteristic targets additionally the analysis of variance (ANOVA) is also applied to identify the welding current is the most significant factor. Experiment with the optimized parameter setting, which have been obtained from the analysis,