Miracle-dz/UniFAR-FTUs huggingface dataset:
Moringa ( Moringa oleifera ): An Alternative Vegetable Source with High Nutritive and Medicinal Values

The immature fruits of moringa are also used in several culinary dishes of tough skin with the skin intact. Tender fruits are also used in samber. Seeds are eaten green or roasted Abstract Moringa oleifera popularly known as Sehjan or drum-stick, native to India, is a multi- purpose tree due to its diverse uses and helpful in eco-restoration. It is widely used as natural medicine, food, feed, biostimulant, forage and migration of bees. Moringa tress is known as a “miracle tree” due to its multipurpose uses. It is an evergreen tall tree with a straight trunk, corky and whitish bark. It grows well in hot, semi-arid and humid regions. Tree has tubular tap root system. Leaves are palish green in colour, compound, tri-pinnate with many small leaflets. Flowers are yellowish white, and fruits are pendulous, triangular which split lengthwise into 3 parts after drying. The pods are 1-4 feet long and 1.5 to 2.0 cm wide with tapering ends. Pods contain many seeds (10-20) embedded in fleshy girth. Seeds are dark brown in colour, and kernel is covered by light wooded shell with three papery wings. Moringa tree is a good source of vitamins, minerals and essential amino acids. It is used as a natural antibiotics and inhibitory biomarker for many plant pathogens. It has medicinal properties like anti-tumor, anti-inflammatory, antioxidants and antimicrobial activities. Moringaceae family includes about 14 species among which Moringa oleifera is considered most important. In this article we have reviewed the multipurpose uses of Moringa olifera to establish as a promising tree to use for food supplement, soil management, animal feed, medicinal purpose and uses in cosmetic and dairy industry etc. It is envisaged that the popularization of this miracle tree will help us towards sustainability, and nutritional security particularly in arid and semi-arid regions of the country.
Cell Biology and Signal Transduction Role of Arabidopsis EpsinR2 in vacuolar trafficking

Members of the epsin family of proteins (epsins) are characterized by the presence of an epsin N-terminal homology (ENTH) domain. Epsins have been implicated in various protein trafficking pathways in animal and yeast cells. Plant cells also contain multiple epsin-related proteins. In Arabidopsis thaliana , EPSIN1 is involved in vacuolar trafficking of soluble proteins. In this study, we investigated the role of Arabidopsis EpsinR2 in protein trafficking in plant cells. EpsinR2 contains a highly conserved ENTH domain, but a fairly divergent C-terminal sequence. We found that the N-terminal ENTH domain specifically binds to phosphatidylinositol-3-phosphate (PtdIns(3)P) in vitro , and has a critical role in the targeting of EpsinR2. Upon transient expression in protoplasts, hemagglutinin (HA) epitope-tagged EpsinR2 (HA:EpsinR2) was translocated primarily to a novel cellular compartment, while a minor portion localized to the Golgi complex. Protein-binding experiments showed that EpsinR2 interacts with clathrin, AtVTI12, and the Arabidopsis homologues of adaptor protein (AP)-3 δ -adaptin and AP-2 α -adaptin. Localization experiments revealed that HA:EpsinR2 co-localizes primarily with δ− adaptin, and partially co-localizes with clathrin and AtVTI12. Based on these findings, we propose that EpsinR2 plays an important role in protein trafficking through interactions with δ -adaptin, AtVTI12, clathrin, and PtdIns(3)P.
Score Manager Discovery in EigenTrust Using Virtual Magnetic Fields

—EigenTrust is a well-known distributed reputation system that uses random nodes (called Score Managers) to compute the reputation of other nodes in the network. In the original proposal, the selection of the Score Managers is made by successive hashes in a DHT. This paper proposes the usage of Virtual Magnetic Fields in replacement of DHTs in the selection of Score Managers in the EigenTrust reputation system. Virtual Magnetic Fields are self-organizing message forwarding mechanisms that are capable of delivering messages to speciﬁc nodes according to some non-functional aspects concerning the application semantics. A comparative analysis showed that the EigenTrust efﬁciency was improved in the proposed solution by removing the cost of the discovery of a Score Manager, and by introducing a low cost method for dissemination of information as nodes join and leave the network.
Targeting 14-3-3ζ overcomes resistance to EGFR-TKI in lung adenocarcinoma via 2

14-3-3ζ EGFR-TKI by EMT We performed global gene expression microarray profiling in EGFR-TKIs-resistant cells after shRNA knockdown of 14-3-3ζ and analyzed the gene expression data. Here, we demonstrted that 14-3-3ζ has positively regulatory effect on the BMP2/Smad/ID1 signaling pathway. Our findings suggest that 14-3-3ζ a novel and potential target for overcoming EGFR-TKIs LUAD an EGFR-activating 14-3-3ζ expression was and predicted unfavourable prognosis in pan-cancer based on We found that high 14-3-3ζ expression was significantly associated with advanced T stage, TNM stage, the present of lymph node metastasis and poor treatment response to EGFR-TKI in LUAD patients with EGFR-activating mutations. Our study provide a molecular rationale for an unappreciated role of 14-3-3ζ in promoting EGFR-TKI resistance accompanied by EMT. Additionally, we showed that 14-3-3ζ positively regulated signaling. BMP2/Smad/ID-1 signaling. This work could help to predict and guide therapeutic responsiveness of EGFR-TKI in LUAD. Our findings suggest that targeting 14-3-3ζ/BMP pathway/EMT could be a potential therapeutic strategy to reverse the EGFR-TKIs resistance in LUAD patients with acquired resistance.
Spatial positioning of CFTR’s pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathway

corroborating the idea that these paired residues are physically close to each other at the external edge of the narrow region. Although these data paint a picture of relatively symmetrical contributions to CFTR’s pore by TM1 and TM6, introducing cysteine pairs between TM6 and TM12 (348C/1141C, 348C/1144C, and 348C/1145C) or between TM1 and TM12 (95C/1141C) yields results that contest the long-held principle of twofold pseudo-symmetry in the assembly of ABC transporters’ TMs. Collectively, these findings not only advance our current understanding of the architecture of CFTR’s pore, but could serve as a guide for refining computational models of CFTR by imposing physical constraints among pore-lining residues.
DEVELOPMENT AND PERFORMANCE ANALYSIS OF A SINGLE AXIS LINEAR MOTOR TEST-BED

The ever-increasing demands placed on industrial machine tool manufacturers, for greater speeds and accuracies, are beginning to exceed the capabilities of current machine tool technologies. How-ever, the ongoing revolution in computer, sensor and actuator technologies has introduced the potential of economically meeting these higher demands through new approaches in machine tool design. One actuator technology currently inﬂuencing high precision industrial automation is the linear motor. This paper details the development of a single axis linear motor test-bed, replicating one axis of a laser cutting machine tool. Through analysis of system stiffness and torque disturbances, the performance of the linear motor driven axis is compared to that of a more common ball screw driven axis.
Tissue-specific regulation of epidermal contraction during C. elegans embryonic morphogenesis

Actin and myosin mediate the epidermal cell contractions that elongate the Caenorhabditis 26 elegans embryo from an ovoid to a tubular-shaped worm. Contraction occurs mainly in the 27 lateral epidermal cells, while the dorsoventral epidermis plays a more passive role. Two parallel 28 pathways trigger actinomyosin contraction, one mediated by LET-502/Rho kinase and the other 29 by PAK-1/p21 activated kinase. A number of genes mediating morphogenesis have been shown 30 to be sufficient when expressed either laterally or dorsoventrally. Additional genes show either 31 lateral or dorsoventral phenotypes. This led us to a model where contractile genes have discrete 32 functions in one or the other cell type. We tested this by examining several genes for either 33 lateral or dorsoventral sufficiency. LET-502 expression in the lateral cells was sufficient to drive 34 elongation. MEL-11/Myosin phosphatase, which antagonizes contraction, and PAK-1 were 35 expected to function dorsoventrally, but we could not detect tissue-specific sufficiency. Double 36 mutants of lethal alleles predicted to decrease lateral contraction with those thought to increase 37 dorsoventral force were previously shown to be viable. We hypothesized that these mutant 38 combinations shifted the contractile force from the lateral to the dorsoventral cells and so the 39 embryos would elongate with less lateral cell contraction. This was tested by examining ten 40 single and double mutant strains. In most cases, elongation proceeded without a noticeable 41 alteration in lateral contraction. We suggest that many embryonic elongation genes likely act in 42 both lateral and dorsoventral cells, even though they may have their primary focus in one or the 43 other cell type.
Using Business Process Simulation to Assess the Effect of Business Rules Automation

--Application of the business rules approach is often argued in research and practice to result in more efficient and enhanced processes. As the extent of this statement has yet to be shown, in this paper the process simulation method is applied to assess the effect of business rules externalization and automation on business process performance. A real-world decision and information intensive process is used here as a case study. Business process simulation is applied here to assess process performance difference between as-is and enhanced to-be process. Comparison of the obtained simulation results of the re-engineered to-be process that includes automated business rules and the as-is process indicate an increase of process performance measured in time and costs while attributing this effect to the automation of identified business rules.
HSOA Journal of Allergy Disorders and Therapy Refractory Hypotension Related to Systemic Mastocytosis Diagnosed After Cytoreductive Therapy for Acute Myeloid Leukemia

re-ceptors blockers with significant improvement in blood pressure (able to taper the vasopressors) and skin rash. Unfortunately, the patient progressively developed acidosis in relation to acute kidney injury secondary to prolonged hypotension, then multi-organ failure and died 2 weeks later. Abstract Systemic Mastocytosis (SM) can be associated with Acute My- eloid Leukemia (AML) and mast cells can be masked on bone marrow biopsy by the high burden of blast cells. Most of the SM-AML pa- tients have associated translocation t(8;21) and mutation of D816V KIT gene which were not present in the reported case. None of the SM-AML cases described in the literature had systemic symptoms secondary to SM. This is the first reported case of life-threatening symptomatic SM in a patient with SM-AML. Checking tryptase levels in symptomatic patients will lead to prompt initiation of mast cell me- diators blocking therapy resulting in improved clinical management.
FORMULATION, DEVELOPMENT AND EVALUATION OF EUGENOL OIL NANOEMULSION GEL FOR TOPICAL DELIVERY

T he aim of the present work was to formulate and characterized the nanoemulsion based gel for poorly water soluble eugenol oil in order to overcome the side-effects associated with its oral delivery. Pseudo-ternary phase diagrams were constructed using titration method. Various components of nanoemulsion were selected on the basis of compatibility study, solubility study and emulsification ability. Nanoemulsion was formulated by ultra-sonication method and characterized for droplet size, poldispersity index, zeta potential, rheological study and in-vitro skin permeation study. The optimized nanoemulsion (FA6) is then converted into nanoemulsion gel using 1% carbapol 934. Drug loaded nanoemulsion gels were evaluated for rheology study, pH, swelling index, uniformity of drug content and permeation study. Transdermal permeation of eugenol oil from nanoemulsion gel was determined by using Franz diffusion cell across excised rat skin. Nanoemulsion gel containing 5% eugenol oil as oil, 30% tween 80, 15% propylene glycol as surfactant and co-surfactant respectively, 60% water and 1% carbapol 934 was concluded as optimized formulation. Formulated nanoemulsion gel was compared with conventional gel formulation for in-vitro permeability. Nanoemulsion gel showed three-fold higher cumulative amount of drug permeation and flux (38.66±0.20) than conventional gel formulation (13.18±0.27). Antimicrobial activity of nanoemulsion gel was done by cup and plate method which shows the high anti-microbial activity than conventional gel and plain drug. Release kinetic study done by using number of release kinetic models for nanoemulsion gel formulation. First order kinetic release model which fit best for the nanoemulsion gel formulation shows the higher linearity of plot was achieved (R 2 – 0.995). Nanoemulsion gel release profile could be best explained by higuchi models. Regression line achieved higher R 2 value (R 2 - 0.991). This indicates slow diffusion of nanoemulsion gel and follows non-fickian transport mechanism as indicated by the n value of 0.860 when fitted to Kors-peppas model. Hence, it can be concluded that nanoemulsion gel formulation will treat microbial growth more effectively than conventional gel formulation.
Time to health-related quality of life improvement as a key outcome in modern anticancer therapies

Objective Major advances have recently been made in the treatments of cancer, which now also have the potential to improve patients’ health-related quality of life (HRQOL). We propose the Time To HRQOL Improvement (TTI) and the Time To Sustained HRQOL Improvement (TTSI) as potentially important cancer outcomes to be used in longitudinal HRQOL analyses. As of we and using the Fine-Gray model to include competing risks in estimates, in a case study in real life of a cohort of newly diagnosed cancer patients receiving a targeted therapy. HRQOL was evaluated before and during therapy with six assessments over a 24 months period, using the well validated EORTC QLQ-C30 questionnaire.
Curcumin-Galactomannoside Interaction Enhances the Bioavailability of Curcumin and Inhibits Inflammation and Oxidative Stress Associated with Experimental Arthritis

Curcumagalactomannosides (CGM) is a novel bio-available formulation. This formulation was made from curcumin (CM) and it comprises with fenugreek derived dietary fibre composed of galactose and mannose units. In the current study was designed to evaluate the anti-inflammatory action of CGM was compared with CM on carrageenan-induced acute model. The result indicated that the CGM showed the minimal dose with potent inhibitory effect than CM. CGM at 100 mg/kg bwt was found to be potent dose from carrageenan model. From the above data, we evaluated its anti-arthritic effect in adjuvant induced chronic arthritic model. Adult male wistar rats were divided into 4 groups: Normal control rats (NC); Adjuvant induced arthritic control rats (AA); AA+ CGM supplemented (100 mg/kg bwt); AA+ indomethacin administrated (IND 3 mg/kg bwt) for 30 days. The activities of inflammatory markers, antioxidant enzymes, histopathology and radiology of rat paw tissue were analyzed. The result indicated that there was a significant increment in the levels of antioxidant enzymes on CGM supplementation. The upregulated gene level expressions of inflammatory markers were down regulated by supplementation of CGM. Supplementation of CGM to arthritic rats significantly improved the histological findings in paw as evident by reduced the massive influx of polymorphonuclear cells infiltration and also CGM protects against excess soft tissue volume, degenerative joint changes, sub-chondral erosion and joint space narrowing by radiological analysis. This current study shows that novel bio-available formulation of curcumin as CGM has an antioxidant, anti-inflammatory and anti-arthritic activity in experimental arthritic model.
Title Comment : Looking for Affective Meaning in " Multiple Arousal " Theory : A Comment to

Picard, Fedor, and Ayzenberg (2016) provide a review of the existing literature on the relationship between electrodermal activity (EDA) and affective processes and present data from a number of studies suggesting strong lateralization in EDA reactivity to emotion. As the authors note, their manuscript extends previous work suggesting the concept of arousal is more complex than previously thought, and they provide a framework for interpreting such complexities within the context of a multiple arousal
SERIES RENT PRESERVATION AND THE PERSISTENCE OF UNDERDEVELOPMENT

When citizens in a poor constrained society are very unequally endowed, they are likely to find it hard to agree on reforms, even though the status quo hurts them collectively. Each citizen group or constituency prefers reforms that expand its opportunities, but in an unequal society, this will typically hurt another constituency’s rents. Competitive rent preservation ensures no comprehensive reform path may command broad support. The roots of underdevelopment may therefore lie in the natural tendency towards rent preservation in a divided society. Raghuram G. Rajan Booth School of Business University of Chicago 5807 South Woodlawn Avenue Chicago, IL 60637 and NBER raghuram.rajan@ChicagoBooth.edu
Coronary Artery Calci ﬁ cation and its Progression it

Coronary artery calci ﬁ cation is concomitant with the development of advanced atherosclerosis. Coronary artery calci ﬁ cation pathologically begins as microcalci ﬁ cations (0.5 to 15.0 m m) and grows into larger calcium fragments, which eventually result in sheet-like deposits ( > 3 mm). This evolution is observed to occur concurrently with the progression of plaque. These fragments and sheets of calci ﬁ cation can be easily identi ﬁ ed by radiography as well as by computed tomography and intravascular imaging. Many imaging modalities have proposed spotty calci ﬁ cation to be a predictor of unstable plaque and have suggested more extensive calci ﬁ cation to be associated with stable plaques and perhaps the use of statin therapy. We will review the pathology of coronary calci ﬁ cation in humans with a focus on risk factors, relationship with plaque progression, correlation with plaque (in)stability, and effect of pharmacologic interventions. (J Am Coll Cardiol Img 2018;11:127 – 42) © 2018 by the American College of Cardiology Foundation. pharmacologic interventions on CAC.
Prevent and Control Gray Mold in the Plant

Botrytis cinerea is a fungus that causes a huge loss of crop production. There is no specific permanent solution for this problem. With various side effects, there are few techniques for reducing this problem. Among all the solutions, chemical fungicide is the main solution for getting rid of this destroyer with a huge side effect. The new approach, transgenic plant production, is a new and effective method compared to any other. This study will focus on the best and most useful properties of transgenic plants compared with other fungicides.
ORCADIAN RHYTHMS OF SENSITIVITY TO INSECTICIDES IN MUSCA DOMESTICA (DIPTERA, MUSCIDAE)

Circadian rhythms of LD50 values to DDT, dieldrin and malathion, topically applied, were determined for houseflies reared under LD 14:10 with “dawn” at 06.00 hr. There was a marked increase in susceptibility at 05.00 hr in each case. With “dawn” at 18.00 hr. , DDT LD50 values were lowest at 17.00 hr indicating independence of the flies' “biological clocks” from clock time of day. Flies reared under LD 18:6 and 10:14 also had circadian rhythms of sensitivity to DDT. Mean daily LD50 values were inversely related to photophase length. The ratios of mean daily LD50 to “pre‐dawn” values were greatest for the longer photophases. Flies reared under LD 14:10 until the pupal stage, then DD until testing showed a normal circadian rhythm. Flies reared in total darkness (DD) showed no diel variations in susceptibility. W.H. O. standard strain flies were used for all the experiments. A fully susceptible (Cooper) and a DDT resistant (DEH‐DOV) strain also showed significant circadian rhythms of sensitivity to DDT.
Foreign direct investment, institutional development, financial development and economic growth

The aim of this paper is to focus on relationship between FDI, financial development, institutional development and economic growth in North African countries from 1995 to 2017. Using the system Generalized Method of Moments (GMM) in a panel data analysis, we justify the positive effect of FDI, institutional development and financial development on the economic growth in North African countries. We also noted the important complement between FDI, institutional development and financial development. impact FDI
ETIOLOGY AND PROPER MANAGEMENT OF BRONCHITIS IN ADULT

: Bronchitis is the widespread inflectional disease. This article focuses on the newest evidence-based management approaches of it. Furthermore, etiology, symptoms and pathophysiology are emphasized. We conducted a systemic review study that performed through Comprehensive literature search was performed in MEDLINE/PubMed and Cochrane Central Register of Controlled Trials. Cough is one of the most prevalent signs and symptom bringing patients to the primary care physician's workplace, and acute bronchitis is normally the medical diagnosis in these patients. Acute bronchitis must be distinguished from other usual medical diagnoses, such as pneumonia and asthma, because these conditions may require particular therapies not showed for bronchitis. Symptoms of bronchitis normally last regarding three weeks. The existence or absence of colored (e.g., environment-friendly) sputum does not reliably set apart in between bacterial and viral reduced breathing tract infections. Viruses are responsible for greater than 90 percent of acute bronchitis infections.
STRATEGY OF SOCIALLY RESPONSIBLE ENTERPRISE PERSONNEL MANAGEMENT

According to the results of the analysis of the strategic personnel development management, it was determined that the development of socially responsible personnel is a top priority of a company, which wants to increase its position in the market and gain the reputation of a responsible employer. High loyalty of the personnel will ensure the growth of a company, so two directions of personnel development on social and environmental basis were proposed. The directions of education of socially responsible personnel were selected, which include many components which can be attributed to health insurance, sorting of garbage in the office, creation of green groups, organization of volunteer initiatives from company employees, balance between work and family, reduction of paper usage, issuance of non-disposable dishware, new standards of socially conscious management, a corporate university and an online learning portal. A strategy of socially responsible enterprise personnel development management is formed, which is aimed at educating the environmental consciousness of the company employees, which, as it was found, will contribute to the growth of employee loyalty, reputation, will shape the image of the green company, reduce the environmental impact, which in turn will ensure the development of environmental innovations, international cooperation, economic efficiency and increased government subsidies.
Cloning of a Lincosamide Resistance Determinant from Streptomyces caelestis, the Producer of Celesticetin, and Characterization of the Resistance Mechanism

Self-resisance has been invstigated in Streptomyces caekstis (producer of the lin ide anbtic celesticetin), from whih a nco dresistance determinant (clr) has been isolated on a 1lo DNA frment and cloned in Streptomyces lividans. The clr product is a specific methylase which produces a sigk residue of N'-monomethyadenine in 23S rRNA at position 2058, thereby rendering the SOS ribosomal subunit resistant to the action of lncosamides.