Miracle-dz/UniFAR-FTUs huggingface dataset:
Study on relationship between serum total light chain κ/λ ratio and typology of multiple myeloma, and the expression of Survivin and Bcl-2 in patients with multiple myeloma

Objective: To investigate the correlation between total light chain κ/λ ratio (sTLC-к/λ) in serum and disease types, as well as the levels of Survivin and Bcl-2 in multiple myeloma (MM). Methods: A total of 80 patients confirmed with MM were included in this study and assigned to the MM group. Another 30 patients without plasmacyte proliferative disorders were enrolled in control group in the same period. MM patients were stratified into subgroups; IgGк MM (n=23), IgGλ MM (n=25), IgAк MM (n=14) and IgAλ MM (n=18). sTLC-к/λ was calculated through an automatic protein analyzer and compared among the different groups. The levels of Survivin and Bcl-2 were detected by immunohistochemistry staining and Real-time PCR, and were compared between the MM group and control group. The correlation between sTLC-к/λ, and disease types and the levels of Survivin and Bcl-2 were performed by Pearson’s correlation analysis. Results: Compared with control group, the significant differences in sTLC-к/λ were found in the MM group (P<0.001). In the IgGк MM group sTLC-к/λ was higher than that in the IgAк MM group, while sTLC-к/λ in the IgGλ MM group was lower than that in the IgAλ MM group. The positive ratio and levels of Survivin and Bcl-2 in the MM group were significantly higher than those in control group (all P<0.001). sTLC-к/λ was positively correlated with IgG level in the IgGк MM group, IgA level in the IgAк MM group, and the levels of Survivin and Bcl-2 (all P<0.05); and sTLC-к/λ was negatively correlated with IgG level in the IgGλ MM group and IgA level in the IgAλ MM group (all P<0.05). Conclusion: In MM, sTLC-к/λ was related with disease type, and the levels of Survivin and Bcl-2 were up-regulated, and sTLC-к/λ was positively-related with the levels of Survivin and Bcl-2, suggesting that sTLC-к/λ is a promising biomarker for diagnosis and prognosis monitoring of IgG type and IgA type MM.
Oncocytic Papillary Carcinoma in an Autonomous Thyroid Nodule

Patient: Female, 30-year-old Final Diagnosis: Papillary thyroid carcinoma Symptoms: Hyperthyroidism • thyroid mass Medication: — Clinical Procedure: Thyroidectomy Specialty: Surgery Objective: Rare disease Background: Thyroid nodules are a common cause of neck swelling in clinical practice, even in iodine-sufficient communities. Most nodules are benign, but malignancy cannot be excluded. The majority of thyroid cancers occur in nonfunctioning nodules, but in rare cases they can present as an autonomous nodule. Papillary carcinoma, the most common type of thyroid malignancy, typically spreads quickly to local lymph nodes; however, current guidelines do not recommend biopsy of autonomous thyroid nodules. Early detection and surgical intervention can be curative in many of these cases. Case Report: This present case involved a woman in her early 30s who presented with an enlarging neck mass. Ultrasound demonstrated a unilateral right thyroid mass, and blood work showed triiodothyronine thyrotoxicosis. Thyroid scintigraphy was performed and showed unilateral increased uptake on the right side. The patient was treated initially with a thyroid lobectomy. Intraoperative frozen sectioning of the removed specimen showed papillary thyroid carcinoma, and a total thyroidectomy was performed. Radioactive iodine ablation therapy was not done, but given the patient’s history and risk factors, recurrence of her disease is unlikely. Conclusions: The vast majority of autonomous thyroid nodules are noncancerous. However, patients should be informed of the possibility of malignancy, and cancer should be ruled out clinically. Papillary thyroid carcinoma accounts for the majority of tumors in both hot and cold nodules. However, the oncocytic subtype seen in the patient in this report is less common, presents a higher risk of recurrence, and typically occurs in older patients. Thyroidectomy is usually curative for patients with papillary thyroid carcinoma.
A Survey on the Performance Analysis of 6t Sram Cell Using Novel Devices

Static Random Access Memory (SRAM) continues to be a critical component across a wide range of microelectronics applications from consumer wireless to high performance processors, multimedia and System on Chip (SoC) applications. As the technology scales down to 32nm and below, the leakage power of Static Random Access Memory (SRAM) are becoming one of the most critical concerns for low power applications. Scaling causes severe Short Channel Effects (SCE) which are difficult to suppress them. To overcome the challenges in nanometer region, many alternate devices like Multi, Gate Field Effect Transistor (MuGFET), Fin-shaped Field Effect Transistor (FinFET), Carbon Nano Tube Field Effect Transistor (CNTFET) and Tunnel Field Effect Transistor (TFET) are used in conventional 6T SRAM cell design. The performance parameters like standby power, dynamic power, write delay, read delay and static noise margin are compared using 32nm technology for the various devices.
Fatty acid composition and antioxidant capacity of pomegranate seed oil

Pomegranate (Punica granatum) is a perennial herb with its long history and has been the symbol of health, fertility and spirituality. In addition to being consumed as fresh fruit, pomegranate is consumed as pomegranate juice, syrup, pomegranate syrup and many different product groups. In particular, pomegranate seeds, which are often produced as waste, are evaluated separately in terms of their fatty acid composition and antioxidant capacity. In this study, the fatty acid composition of pomegranate seed oils was determined by gas chromatography/mass spectrophotometry (GC/MS). Total antioxidant activity analysis was performed using DPPH (2, 2-diphenyl-1-picrylhydrazyl) method and antioxidant activity value was determined as trolox equivalent (TE). In the study, it was determined that the antioxidant capacity was 171.44 mg TE / 100g. According to GC / MS analysis, it was determined that the most dominant fatty acid was punicic Acid (68.12%). Oleic acid (8.51%), linoleic acid (6.71%) and palmitic acid (5.55%) are the highest fatty acids after punicic acid. It is clear that apart from the widespread consumption of pomegranate fruit, which is very beneficial for health, its seeds can also be used.
Embodied Third-Person Virtual Locomotion using a Single Depth Camera

Third-person is a popular perspective for video games, but virtual reality (VR) seems to be primarily experienced from a ﬁrst-person point of view (POV). While a ﬁrst-person POV generally offers the highest presence; a third-person POV allows users to see their avatar; which allows for a better bond, and the higher vantage point generally increases spatial awareness and navigation. Third-person locomotion is generally implemented using a controller or keyboard, with users often sitting down; an approach that is considered to offer a low presence and embodiment. We present a novel third-person locomotion method that enables a high avatar embodiment by integrating skeletal tracking with head-tilt based input to enable omnidirectional navigation beyond the conﬁnes of available tracking space. By interpreting movement relative to an avatar, the user will always keep facing the camera which optimizes skeletal tracking and keeps required instrumentation minimal (1 depth camera). A user study compares the performance, usability, VR sickness incidence and avatar embodiment of our method to using a controller for a navigation task that involves interacting with objects. Though a controller offers a higher performance and usability, our locomotion method offered a signiﬁcantly higher avatar embodiment.
Empirical Analysis of Intellectual Capital and Firm’s Performance: Evidence from Nigeria

One of the most significant challenges of firms in a matured industry is to remain competitive, increase market shares and growth. Many firms often deploy their available resources to relevant quarters to achieve a competitive edge over its rivals, but little attention has been paid to intellectual capital as a non-material resource of attaining a competitive edge. This study seeks to explore the effect of human, structural and relational capital on operational performance of hospitality firms. The study adopted a survey research design whereby questionnaires were administered to a sample of two hundred and forty (240) respondents. Multiple regression analysis was employed to test the three (3) hypotheses formulated. The study found that human, structural and relational capital have a significant and positive effect on operational performance. The study concludes that intellectual capital is an important and necessary factor to be considered by firms in terms of achieving competitive advantage. The study recommends intensive and well-structured training for staff, the creation of corporate memory as well as the improved relationship with stakeholders.
Deep Learning Grading System for Diabetic Retinopathy using Fundus Images. (Dept. E)

IABETIC Retinopathy (DR) is one of the main causes of visual blindness. According to the recent report of the Vision Loss Expert Group (VLEG) of the global burden of disease study, DR has increased the number of blind people, during the period from 1990 to 2015, from 0.2 million to 0.4 million [1]. Early recognition of DR is the way to prevent the occurrence of blindness. The evolution of DR in the patient is determined by the presence of anomaly lesions, such as microaneurysms [2], hemorrhages [3], and hard exudates [4],[5]. This paper aims at providing an automated DR grading system that can not only recognize early DR occurrence
Modelling repeated paired phonetic measures using linear mixed models with correlated errors

Frédérique Letué Univ. Grenoble Alpes, LJK, F-38000 Grenoble, France, CNRS, LJK, F-38000 Grenoble, France Marie-José Martinez Univ. Grenoble Alpes, LJK, F-38000 Grenoble, France, CNRS, LJK, F-38000 Grenoble, France Sandra Cornaz Univ. Grenoble Alpes, CNRS, GIPSA-Lab, F-38000 Grenoble, France Nathalie Vallée Univ. Grenoble Alpes, CNRS, GIPSA-Lab, F-38000 Grenoble, France Nathalie Henrich Bernardoni Univ. Grenoble Alpes, CNRS, GIPSA-Lab, F-38000 Grenoble, France
Veriﬁcation of Hierarchical Control via Approximate Simulation and Feedback Linearization

—The project is to verify approximate simulations of hierarchical controllers for high-order nonlinear systems that are feedback linearizable. Recent work has been done by J. Fu, [1] (2013) and G. J. Pappas [2] (2000) on the production of low-order linear controllers via approximate simulation relation, which is the basis for the project. Creating low-order speciﬁcations that guarantee correctness under unknown disturbances in the original high-order system remains an open scientiﬁc question. Progress will be made towards veriﬁcation by considering the simpliﬁed scaling chains of integrators problem
Digital spillovers and SMEs’ performance in Sub-Saharan Africa

poli cy brief According to the IMF (2020), 20 million jobs per year have to be provided in Sub-Saharan Africa (SSA) to absorb the growing workforce in the subcontinent. Yet, the potential of simple digital technologies such as email, websites, and mobile money in terms of wealth and job creation has not been fully exploited by African firms. While the uptake of mobile phone technology has facilitated a multiplication of Internet-based innovations throughout the region, this dynamic is hampered by a large Internet divide and low penetration of these technologies among firms and individuals. In 2015, African countries’ Internet penetration rates did not exceeding 60 percent of the population, with some countries like Niger, Sierra Leone, or Guinea-Bissau displaying penetration rates lower than five percent of the population. /. Chair “Digital Trust” . Digital for Development Research Initiative
Entwicklung und Anwendung massenspektrometrischer Methoden zur Analyse von proteasekatalysierten Reaktionen

Proteasen ubernehmen als hydrolytische Enzyme zentrale Funktionen in den verschiedensten physiologischen sowie pathologischen Prozessen und sind deshalb von sehr grosem Interesse fur die Entwicklung neuer Krankheitstherapien. Zur Analyse proteasekatalysierter Reaktionen gewann die Massenspektrometrie in den letzten Jahren zunehmend an Bedeutung. In der vorliegenden Arbeit wurden auf dieser Technologie basierende Methoden entwickelt und auf drei verschiedene Fragestellungen angewendet: (i) Bestimmung der Spaltspezifitat von ADAM10 und ADAM17, (ii) Zeitaufgeloste Analyse proteasekatalysierter Reaktionen mittels LC-MS und (iii) Identifizierung von Meprin-alpha/-beta Spaltstellen in Interleukin-6.
Robust Reachable Set: Accounting for Uncertainties in Linear Dynamical Systems

Reachable set computation is one of the primary techniques for safety verification of linear dynamical systems. In reality the underlying dynamics have uncertainties like parameter variations or modeling uncertainties. Therefore, the reachable set computation must consider the uncertainties in the dynamics to be useful i . e . the computed reachable set should be over or under approximation if not exact. This paper presents a technique to compute reachable set of linear dynamical systems with uncertainties. First, we introduce a construct called support of a matrix. Using this construct, we present a set of sufficient conditions for which reachable set for uncertain linear system can be computed efficiently; and safety verification can be performed using bi-linear programming. Finally, given a linear dynamical system, we compute robust reachable set, which accounts for all possible uncertainties that can be handled by the sufficient conditions presented. Experimental evaluation on benchmarks reveal that our algorithm is computationally very efficient.
Conficker Botnet Prevention: Crypto-Pan Algorithm

— This paper measure the potential power of Conficker to estimate its effects on the networks/hosts when it performs malicious operations. Isolating the BotNet traffic from regular traffic makes sharing of the data possible. It uses Address anonymization can be done by Cryptography-based Prefix preserving Anonymization algorithm (Crypto-Pan) to control the attack of Conficker botnet. The above method for anonymizing has many benefits. Crypto-PAn is a cryptography-based sanitization algorithm for network trace owners to anonymize the IP addresses of Conficker botnet and their traces in a prefix-preserving manner.
Renal tubular injury as an uncommon presentation of Wilson’s disease

Wilson's disease is an autosomal recessive disorder caused by a mutant ATP7B gene on chromosome 13. This mutation causes a reduction in hepatic copper excretion, which accumulates in hepatocytes and deposits in other tissues and organs (brain, cornea, kidney, etc.) as the disease progresses. Wilson's disease was described worldwide, with estimated prevalence of one case per 30,000 live births. Age of presentation is usually 4-60 years; however, the disease may present at any age. Clinical manifestations are predominantly hepatic, neurologic and psychiatric. Renal involvement is less common and characterized by proximal tubular dysfunction, Glomerular Filtration Rate (GFR) decline, renal tubular acidosis, aminoaciduria and nephrolithiasis. Herein, we aimed to report a case which describes an uncommon path to the diagnosis of this rare, yet well-known disease. The diagnosis resulted from an investigation of acute kidney injury in a 48-year-old man. Keywords: Wilson’s disease; Acute kidney injury; Renal tubular injury.
STRUCTURAL DYNAMICS OF SKIN REGENERATION AFTER THERMAL BURNS IN CONTROLLED WATER ENVIRONMENT (experimental study)

The purpose of the study was to determine the structural dynamics of healing and skin regeneration characteristics after thermal burns in laboratory rodents in an artificial local regeneration environment - the burn surface is protected by the dome of the device filled with regularly replaced sterile isotonic saline solution. The article presents characteristics of the inflammatory response reaction to steam burns and subsequent skin regeneration in the following comparative aspect: during natural healing under the eschar and in case of constant contact of the burn surface with solutions. Scientific novelty consists in the study of changes in the inflammatory and regenerative response depending on the state of state of aggregation of matter interacting with a wound. It was concluded that secondary skin alteration and fibrous changes in water environment are much lower with considerably higher degree of regeneration. These data can serve as the basis for new regenerative technologies in combustiology.
Design of Dual-Band Band Pass Filter Using CSRR

A Filter block has been highly attention due to its highly importance in wireless communication systems. High consonant level regularly organizations with the execution of the filter block. The utilization of both low-pass or band-stop channel and the progression impedance lines techniques to lessen the deceptive qualities of the channel are not a pragmatic arrangements since that includes greater intricacy and huge in measure. In this paper, a solitary unit cell of a corresponding split ring resonator composed on the ground plane of the ordinary five shaft bandpass channel has been proposed and considered as more functional technique to energize the second bandpass recurrence band and to take care of the essential channel issue as far as third request symphonious trademark concealment (3fo). The last structure has been mimicked utilizing the CST Microwave Studio. The yields appeared and furthermore return misfortune upgrade is clear through the blend between the corresponding split ring resonators and band pass channel. Different focal points no many-sided quality includes and low in powerful cost.
Discourses emerging from the experiences of the women mothers, victims of violence

The paper discusses the main discourses emerging from the experiences of women mothers who have suffered violence. It challenges the several conventional frames used to describe victims, such as the heroine model of a woman victim who has the courage to leave the abusive relationship and, conversely, the blameful model of a woman victim who, as research points out, prefers to remain in the marriage (or relationship) and tolerate violence. Findings concern the first phase results of the VICTIMS project (2009-2011), which was designed and conducted in four European countries with co-funding obtained by the DAPHNE III programme. The paper particularly discusses the findings that have emerged from a series of seventeen indepth interviews that were conducted with mothers from Cyprus, who have been victims of violence. All these seventeen case studies are explanatory, since they aimed to explore causation in order to find major thematic elements and underlying discourses shaping the identities of the women victims. Data have been analyzed mainly qualitatively. Results indicate that the woman’s attitude as a victim of violence is mainly determined by the discourses of powerlessness, tolerance, denying, blaming self, compassion, and dependency.
A Haar-Cascade classifier based Smart Parking System

– In this paper, we present the implementation of a Haar–Cascade based classifier for car detection. This constitutes the detection sub-module of the framework for a Smart Parking System (SParkSys). In high density cities, finding available parking can be time consuming and results in traffic congestions as drivers cruise to find parking. The computer vision based smart parking solution presented in this paper has the advantage of being the least intrusive of most car sensing technologies. It is scalable for use with large parking facilities. Functional code from OpenCV was used in conjunction with custom Python code to implement the algorithm. Our tests show mixed results, with excellent true positive detections along with some with false negatives. Remarkable is that the classification algorithm learnt features that are common across a wide range of objects of interest.
INSECTS’ SOCIAL PHYSIOLOGY

Since the middle of the 20th century, improvements in analytical technologies have permitted the identification of cuticular hydrocarbons present on the cuticle of almost all insects. Concomitantly, a great deal of attention has been paid to the determination of their role at the individual, colonial, and populational level. Many studies pointed to the importance of the surface lipids which cover the insects' cuticle. They are important for the survival of individuals and at a higher level, to maintain colony integrity and species survival. The lipid layer is responsible for the water-repellent character of the cuticle which is its primary function. It reduces surface transpiration and protects terrestrial insects from desiccation. Furthermore, it creates a barrier against micro-organisms and inorganic chemical components. More recently, bioassays have shown that surface hydrocarbons are important tools for recognition systems for solitary insects but above all, for social insects where the chemical communications between individuals are complex. Cuticular hydrocarbons serve as contact pheromones when insects encounter each other. They permit insects to identify « friends » from « foes », nestmates from nonnestmates. They constitute a true chemical signature. They also maintain the social structure of insect colonies by separating individuals according to their functions within the colony, according to their physiological states and their hierarchical rank. They constitute a fertility signal for the queen which indicates its presence for the workers which retain their reproduction. Furthermore, cuticular hydrocarbons can play a major role in sexual behavior as an attractant or repellent. They can also be involved in courtship behavior. These are kairomones or allomones in host-parasite and prey-predator relationships, and contribute to mutualistic relations between insects. E. Provost, O. Blight, A. Tirard et al. 20 Nowadays, the identification of all these functions allows biologists to use cuticular hydrocarbons as tools to conduct eco-ethological studies. For example, it is possible to use hydrocarbon composition as taxonomic character to identify cryptic species which are morphologically close. This could be useful in conservation planning. These components should equally allow a better understanding of ant colonies structure, for instance, the boundaries of polydomous colonies or especially in the context of an invasion when ants form super-colonies.
FACTORS INHIBITING ORGANIC FARMING IN KERALA AND TAMIL NADU STATES: AN EXPLORATORY ECONOMIC ANALYSIS

This study has made an attempt to identify the major factors inhibiting the farmers in organic farming in Kerala and Tamil Nadu states. It is seen that the practice of organic farming is gaining momentum in India and a large number of farmers are switching over from inorganic farming to organic farming. It is evident the note that in India, Kerala and Tamil Nadu are the major states where there are a large number of farmers more from inorganic farming to organic farming but at the same time, there are certain factors which inhibit the farmers to involve in the practice of organic farming. In view of this, this study has made an attempt to comparatively analyse the major factors inhibiting the farmers in organic farming and inorganic farming in Kerala and Tamil Nadu States.