Miracle-dz/UniFAR-FTUs huggingface dataset:
Overview of SNPs Associated with Trans Fat Content in Cow’s Milk

Lipids consumed with milk derivatives are one of the main parts of the human diet. Trans fatty acids in milk are causing a debate about their impact on the incidence of cardiovascular disease, pathological abnormalities, and cancer. The fatty acid profile of milk is influenced by a large number of different factors, one of which is genetic. The development of genetic studies, including Genome-Wide Association Studies (GWAS), may help define genomic regions associated with fatty acid content in milk, including trans fatty acids. This article provides an overview of international studies on the identification of genomic regions and SNPs associated with the trans fatty acids in cow’s milk. The results are based on research of cattle such as Norwegian Red cattle, Holstein, Jersey, and Brown Swiss. The presented review shows that 68 SNPs were localized on chromosomes 1, 2, 4–6, 8–10, 12, 14–20, 22–25, and 27–29. Further research in this direction will provide new information that will serve as an impetus for the creation of modern breeding technologies and increase the performance of the manufacture of high-quality dairy products. The search for genetic markers associated with the content of TFA in milk is a promising direction in agricultural science and will allow more complete breeding work with cattle.
Advances in Gene Silencing Technology

Gene silencing is an important means of regulating gene expression in an organism, and this technique can reduce or block the expression level of a target gene. There are many types of gene silencing techniques, among which the more widely used are CRISPR/Cas9, TALEN, RNAi and so on. In recent years, with the gradual improvement and popularization of biotechnology, gene silencing techniques are slowly becoming known and applied in many fields such as gene research, disease treatment and breeding of new plant varieties. However, not all gene silencing can achieve the desired effect, and there are many reasons affecting the outcome of gene silencing. The target gene is not the only gene that determines the phenotype and there is no significant effect after knocking out the target gene. The technique also has a certain off-target rate, which can also lead to operational failure. This paper describes the principles and applications of three gene silencing techniques and compares the advantages and disadvantages of the three gene silencing techniques in order to select the most suitable gene silencing method from multiple perspectives. The current problems of CRISPR/Cas9 technology are summarized to provide certain ideas for the future development and research of CRISPR/Cas9 technology
The Transformative Potential of Artificial Intelligence in Medical Billing: A Global Perspective

This paper explores the transformative potential of Artificial Intelligence (AI) in revolutionizing medical billing processes worldwide. As healthcare systems face increasing complexities and challenges, AI offers innovative solutions to streamline billing operations, enhance accuracy, and improve financial outcomes. By automating the claims processing workflow, AI can significantly reduce the administrative burden on healthcare providers, allowing them to focus more on patient care. AI-powered coding accuracy systems can analyze medical records and suggest appropriate billing codes, reducing coding errors and claim rejections. AI can also optimize reimbursement strategies by analyzing historical data and identifying patterns to ensure optimal reimbursement rates for healthcare providers. To address the growing concern of healthcare fraud, AI algorithms can analyze vast amounts of data, detect suspicious patterns, and flag potentially fraudulent activities, thus preventing financial losses. Moreover, AI-powered chatbots and virtual assistants can enhance patient engagement by providing personalized support, answering billing-related queries, and guiding patients through the payment process. Adoption of AI in medical billing brings various benefits, it also presents challenges such as data privacy, algorithm bias, and the need for robust infrastructure and training. Successful case studies from various healthcare settings worldwide demonstrate the tangible advantages of AI implementation, such as reduced billing errors, accelerated reimbursement cycles, and improved patient satisfaction. By harnessing the power of AI, healthcare systems can achieve greater efficiency, financial sustainability, and improved patient experiences.
Marching to Many Distant Drummers

We address the problem of determining the time in a network where a node may obtain information indirectly from primary time sources via intermediate nodes. Our key idea is to transmit and store each time datum as a pair, consisting of a time interval and a “failure predicate”, a boolean expression that indicates precisely which combinations of node failures could invalidate the interval. We describe some techniques based on this idea, but not a complete system design or implementation.
A aceitação e a satisfação do usuário final do sistema integrado de administração financeira (SIAFI): análise em uma instituição de ensino federal

O Sistema Integrado de Administração Financeira do Governo Federal – SIAFI é uma ferramenta informatizada desenvolvida para processar e controlar a execução orçamentária, financeira, patrimonial e contábil dos órgãos da Administração Pública Federal. Este estudo tem por objetivo avaliar como se relacionam a aceitação de tecnologia e o nível de satisfação dos usuários finais do SIAFI no contexto de uma instituição de ensino federal. Para isso, se utiliza dos estudos inerentes à aceitação e uso de tecnologia e da satisfação do usuário final de computação, mais especificamente do modelo da Teoria Unificada de Aceitação e Uso de Tecnologia (UTAUT) e do modelo de identificação da Satisfação do Usuário Final com a Computação (EUCS). Os dados utilizados foram primários, originários das respostas de 51 usuários do SIAFI a uma survey. Para a análise dos dados, utilizou-se análises de variáveis por meio de Modelagem de Equações Estruturais pelos Mínimos Quadrados Parciais (PLS-SEM). Os resultados das análises confirmaram seis das oito hipóteses analisadas, corroborando que os constructos pertencentes ao modelo UTAUT, comportam-se como preditores da satisfação dos usuários finais do SIAFI, mensurados pelos constructos do modelo EUCS.
Genome-Wide Identification and Comparative Transcriptome Methods Reveal FaMDHAR50 Regulating Ascorbic Acid Regeneration and Quality Formation of Strawberry Fruits

Ascorbic acid (AsA) is a crucial water-soluble antioxidant in strawberry fruit, but limited research is currently available on the identification and functional validation of key genes involved in AsA metabolism in strawberries. This study analyzed the FaMDHAR gene family identification, which includes 168 genes. Most of the products of these genes are predicted to exist in the chloroplast and cytoplasm. The promoter region is rich in cis-acting elements related to plant growth and development, stress and light response. Meanwhile, the key gene FaMDHAR50 that positively regulates AsA regeneration was identified through comparative transcriptome analysis of ‘Benihoppe’ strawberry (WT) and its natural mutant (MT) with high AsA content (83 mg/100 g FW). The transient overexpression experiment further showed that overexpression of FaMDHAR50 significantly enhanced the AsA content by 38% in strawberry fruit, with the upregulated expression of structural genes involved in AsA biosynthesis (FaGalUR and FaGalLDH) and recycling and degradation (FaAPX, FaAO and FaDHAR) compared with that of the control. Moreover, increased sugar (sucrose, glucose and fructose) contents and decreased firmness and citric acid contents were observed in the overexpressed fruit, which were accompanied by the upregulation of FaSNS, FaSPS, FaCEL1 and FaACL, as well as the downregulation of FaCS. Additionally, the content of pelargonidin 3-glucoside markedly decreased, while cyanidin chloride increased significantly. In summary, FaMDHAR50 is a key positive regulatory gene involved in AsA regeneration in strawberry fruit, which also plays an important role in the formation of fruit flavor, apperance and texture during strawberry fruit ripening.
Hydrodynamic instabilities of flows involving melting in under-saturated porous media

The process of melting in partially saturated porous media is modeled for flow displacements prone to hydrodynamic instabilities due to adverse mobility ratios. The effects of the development of instabilities on the melting process are investigated through numerical simulations as well as analytical solution to unravel the physics of the flow. The effects of melting parameters, namely, the melting potential of the fluid, the rate of heat transfer to the frozen phase, and the saturation of the frozen material along with the parameters defining the viscous forces, i.e., the thermal and solutal log mobility ratios are examined. Results are presented for different scenarios and the enhancement or attenuation of instabilities are discussed based on the dominant physical mechanisms. Beside an extensive qualitative analysis, the performance of different displacement scenarios is compared with respect to the melt production and the extent of contribution of instability to the enhancement of melting. It is shown that the hydrodynamic instabilities tend in general to enhance melting but the rate of enhancement depends on the interplay between the instabilities and melting at the thermal front. A larger melting potential and a smaller saturation of the frozen material tend to increase the contribution of instability to melting.
THE EFFECT OF PRODUCT QUALITY AND SERVICE QUALITY ON CONSUMER SATISFACTION AND REPURCHASE INTEREST (STUDY AT STARBUCKS)

This study tested and analyzed product quality, service, customer satisfaction, and consumer repurchase interest at Starbucks Indonesia. The research population sample is Starbucks Indonesia Consumers with a sample size of 105 respondents. In testing the data analysis hypothesis using SPSS Version 21.0, the results show that product quality and service quality significantly affect consumer satisfaction. Product quality and consumer satisfaction affects repurchase intention, but service quality has no significant effect on the repurchase intention.
Aerial online mapping on‐board system by real‐time object detection for UGV path generation in unstructured outdoor environments

An optimal path provides efficient operation of unmanned ground vehicles (UGVs) for many kinds of tasks such as transportation, exploration, surveillance, and search and rescue in unstructured areas that include various unexpected obstacles. Various onboard sensors such as LiDAR, radar, sonar, and cameras are used to detect obstacles around the UGVs. However, their range of view is often limited by movable obstacles or barriers, resulting in inefficient path generation. Here, we present the aerial online mapping system to generate an efficient path for a UGV on a two‐dimensional map. The map is updated by projecting obstacles detected in the aerial images taken by an unmanned aerial vehicle through an object detector based on a conventional convolutional neural network. The proposed system is implemented in real‐time by a skid steering ground vehicle and a quadcopter with relatively small, low‐cost embedded systems. The frameworks and each module of the systems are given in detail to evaluate the performance. The system is also demonstrated in unstructured outdoor environments such as in a football field and a park with unreliable communication links. The results show that the aerial online mapping is effective in path generation for autonomous UGVs in real environments.
THE EFFECT OF FACEBOOK SOCIAL MEDIA PROMOTION, PRODUCT QUALITY AND PRICE ON THE PURCHASE DECISION OF ZACK KREZZ CHIPS (CASE STUDY ON ZACK KREZZ CHIPS CUSTOMERS SEI RAMPAH DISTRICT

This study aims to determine the effect of Facebook Social Media Promotion, Product Quality and Price on Purchase Decisions for Zack Krezz Chips Customers, Sei Rampah District. This type of research is explanatory research that explains the causal relationship between variables through hypothesis testing with a quantitative approach. The sample in this study were 72 respondents using a non-probability sampling technique with a simple random sampling approach. The test tool used is Statistical Product and Service Solutions (SPSS) using SPSS 25 software. The results of this test conclude that Facebook Social Media Promotion has a significant effect on purchasing decisions,
Acceptors and Effectors Alter Substrate Inhibition Kinetics of a Plant Glucosyltransferase NbUGT72AY1 and Its Mutants

One of the main obstacles in biocatalysis is the substrate inhibition (SI) of enzymes that play important roles in biosynthesis and metabolic regulation in organisms. The promiscuous glycosyltransferase UGT72AY1 from Nicotiana benthamiana is strongly substrate-inhibited by hydroxycoumarins (inhibitory constant Ki < 20 µM), but only weakly inhibited when monolignols are glucosylated (Ki > 1000 µM). Apocarotenoid effectors reduce the inherent UDP-glucose glucohydrolase activity of the enzyme and attenuate the SI by scopoletin derivatives, which could also be achieved by mutations. Here, we studied the kinetic profiles of different phenols and used the substrate analog vanillin, which has shown atypical Michaelis–Menten kinetics in previous studies, to examine the effects of different ligands and mutations on the SI of NbUGT72AY1. Coumarins had no effect on enzymatic activity, whereas apocarotenoids and fatty acids strongly affected SI kinetics by increasing the inhibition constant Ki. Only the F87I mutant and a chimeric version of the enzyme showed weak SI with the substrate vanillin, but all mutants exhibited mild SI when sinapaldehyde was used as an acceptor. In contrast, stearic acid reduced the transferase activity of the mutants to varying degrees. The results not only confirm the multi-substrate functionality of NbUGT72AY1, but also reveal that the enzymatic activity of this protein can be fine-tuned by external metabolites such as apocarotenoids and fatty acids that affect SI. Since these signals are generated during plant cell destruction, NbUGT72AY1 likely plays an important role in plant defense by participating in the production of lignin in the cell wall and providing direct protection through the formation of toxic phytoalexins.
Uni-Directional Motion Stability of Spatial Resolution Coverage Discs

A brief account of image synthesis via interferometry using collected light beams from selected pairs of telescopes that constitute a formation of free-flying telescopes is presented. A measure of image quality is adopted that accounts for the optical performance and geometry of the telescopes. Acceptable image quality is achieved when the MTF assumes sufficient magnitudes everywhere within the resolution disc in the spatial resolution plane of the equivalent optical system. The problem is thus a coverage problem where we formulate and find the necessary conditions for optimality and specialize them to distinct cases relevant to the multi-spacecraft imaging situation.
Importance of Photo-Realistic and Dedicated Simulator in Agricultural Robotics

Agricultural robotics is a comparatively new field. Recently, it has gotten special attention because of agricultural labor shortages and rising labor costs. With the increasing operational use of agricultural robots, the need for a dedicated robotic simulator for such activity has been noted here. The need of a dedicated and specialty simulator for agricultural robotics research is the main focus area of this paper. Moreover, limitations have been pointed out when conventional robot simulators are used directly in agricultural settings. In a nutshell, it has been tried to emphasize that a dedicated simulator for agricultural robotics would be a timely advance and would accelerate the growth of agricultural robots.
Research on security protection framework of power communication network based on software defined network

Under the background of "carbon peak and carbon neutrality", the scale of the power grid is increasingly expanding, the intelligence level of the power grid is continually improving, and the dependence of the power system on the communication network is increasingly increasing. The existing power communication network has numerous problems, such as network architecture, upper business support, network operation and maintenance management. This paper first introduces the development status and conceptual principles of SDN (Software Defined Network), based on the advantages and disadvantages of SDN architecture, the common attack types and defense methods are introduced. By combining the advantages of SDN architecture and traditional power communication network, a new security defense framework of power communication network is designed. Finally, a new power communication scheme with open, numerical control separation and controller centralized management is constructed, and the new power communication scheme is summarized and prospected.
Mapping sparse signed graphs to (K2k,M) $({K}_{2k},M)$

A homomorphism of a signed graph (G,σ) $(G,\sigma )$ to (H,π) $(H,\pi )$ is a mapping of vertices and edges of G $G$ to (respectively) vertices and edges of H $H$ such that adjacencies, incidences, and the signs of closed walks are preserved. We observe in this work that, for k≥3 $k\ge 3$ , the k $k$ ‐coloring problem of a given graph G $G$ can be captured by homomorphism to (K2k,σm) $({K}_{2k},{\sigma }_{m})$ from a signed bipartite graph that is built from G $G$ . Here σm ${\sigma }_{m}$ assigns a negative sign to the edges of a perfect matching and a positive sign to the rest. Motivated by these reformulations and in connection with results on 3‐colorings of planar graphs, such as Grötzsch's theorem, we prove that any signed graph with the maximum average degree strictly less than 145 $\frac{14}{5}$ admits a homomorphism to (K6,σm) $({K}_{6},{\sigma }_{m})$ . For k≥4 $k\ge 4$ , we show that the maximum average degree being strictly less than 3 would suffice for a signed graph to admit a homomorphism to (K2k,σm) $({K}_{2k},{\sigma }_{m})$ . Both of these bounds are tight. We discuss applications of our work to signed planar graphs and its connection to the study of homomorphisms of 2‐edge‐colored graphs. Among a number of interesting questions that are left open, a notable one is a possible extension of Steinberg's conjecture for the class of signed bipartite planar graphs.
Unveiling the spatial distribution and molecular mechanisms of terpenoid biosynthesis in Salvia miltiorrhiza and S. grandifolia using multi-omics and DESI–MSI

Abstract Salvia miltiorrhiza and S. grandifolia are rich in diterpenoids and have therapeutic effects on cardiovascular diseases. In this study, the spatial distribution of diterpenoids in both species was analyzed by a combination of metabolomics and mass spectrometry imaging techniques. The results indicated that diterpenoids in S. miltiorrhiza were mainly abietane-type norditerpenoid quinones with a furan or dihydrofuran D-ring and were mainly distributed in the periderm of the roots, e.g. cryptotanshinone and tanshinone IIA. The compounds in S. grandifolia were mainly phenolic abietane-type tricyclic diterpenoids with six- or seven-membered C-rings, and were widely distributed in the periderm, phloem, and xylem of the roots, e.g. 11-hydroxy-sugiol, 11,20-dihydroxy-sugiol, and 11,20-dihydroxy-ferruginol. In addition, the leaves of S. grandifolia were rich in tanshinone biosynthesis precursors, such as 11-hydroxy-sugiol, while those of S. miltiorrhiza were rich in phenolic acids. Genes in the upstream pathway of tanshinone biosynthesis were highly expressed in the root of S. grandifolia, and genes in the downstream pathway were highly expressed in the root of S. miltiorrhiza. Here, we describe the specific tissue distributions and mechanisms of diterpenoids in two Salvia species, which will facilitate further investigations of the biosynthesis of diterpenoids in plant synthetic biology.
Electrostatic Layer Jamming Variable Stiffness Enhanced by Giant Electrorheological Fluid

The traditional electrostatic layer jamming (ELJ) utilizes air as the dielectric, which leads to the ELJ system that can withstand less voltage. A novel electrostatic layer jamming based on giant electrorheological fluid (ELJ-GERF) for soft robotics is proposed in this paper. The principle of ELJ-GERF is to use electrostatic attraction to squeeze the flexible planar electrodes to generate friction and then engage jamming, where GERF acts as the dielectric. Three specimens for variable tensile stiffness applications, namely ELJ-GERF, ELJ-AIR, and ELJ-OIL, are fabricated by adding giant electrorheological fluid, air, and silicone oil. Tensile experiments are conducted to investigate the stiffness adjustment characteristics of these specimens. Advantages of ELJ-GERF are indicated by the experimental results. ELJ-GERF has a more than 4 times faster response time than well-known pneumatic layer jamming. Compared to ELJ, the stiffness variation range of ELJ-GERF is enhanced by more than 1.7 times under DC voltage and more than 1.9 times under AC voltage. And the decay rate of the output force of the ELJ-GERF is reduced by a factor of nearly 3 at DC voltage. Moreover, the ELJ-GERF system has better stability at AC voltage and can withstand about 6.7 times higher breakdown voltages. We found that the GERF particles have an important effect on the variable stiffness performance of ELJ-GERF and that the application of AC voltage can further improve the stiffness of the specimen. The stiffness of ELJ-GREF increased nearly four times at 5000V applied. The same enhancement exists for the ELJ-AIR and ELJ-OIL.
How do visitors’ perceptions differ from the supply of cultural ecosystem services in urban parks? A case study from Beijing

ABSTRACT As urban green spaces, parks can provide rich cultural ecosystem services (CES), enhancing the well-being of those living in urban areas. Understanding how people perceive the CES supplied by parks and identifying differences with their supply is crucial for decision-makers and urban planners. In this study, we conducted a quantitative assessment of CES by combining an expert field investigation of parks with visitor questionnaires in the Three Hills and Five Gardens area of Beijing, China. Our assessment system comprised five categories of CES (landscape aesthetics, historical heritages, education, recreation, health and fitness) and eleven indicators. We identified differences between CES supply and perceptions and noted that such discrepancies additionally vary by CES type. We found that multiple CES are interdependent and interwoven. In addition, we discovered that perceptions of historical heritages service are particularly dependent on supply, while perceptions of health and fitness service are relatively independent of the supply. We explored the reasons behind these differences, finding that the visibility and prestige of historical heritages as well as the positioning and the overall condition of parks can affect visitors’ perceptions. Our assessment can be used to guide the optimization of parks so that they may provide higher-quality CES for the public.