Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Antioxidant Supplementation on Metabolic Disorders in Obese Patients from Randomized Clinical Controls: A Meta-Analysis and Systematic Review

Purpose This systematic review and meta-analysis aim at elucidating the heterogeneity in beneficial effects of antioxidant supplementation in obese adults by exploring the differential effects of antioxidant supplementation on basic indicators of obesity, lipid metabolism, systemic antioxidant capacity, inflammatory biomarkers, and liver function. Methods The inclusion criteria specified randomized controlled trials with antioxidant intervention for adults (mean body mass index (BMI) > 30), from inception to Aug. 8, 2021, in the PubMed, Embase, The Cochrane Library, Web of Science, and Scopus databases. Meta-analysis and publication bias were performed using RevMan 5.4 software. Stata16 software was used to detect publication bias with Egger's and Begg's methods being mainly used. The data of basic indicators of obesity, lipid metabolism index, oxidative stress index, inflammatory biomarkers, and liver function index were collected to analyze the beneficial effects of antioxidant supplementation in obese patients. Results A total of 30 studies were included in this study with a sample of 845 obese patients from the antioxidant supplementation group and 766 obese patients from the placebo control group. The meta-analysis showed that obese patients with antioxidant supplementation had lower BMI (mean difference (MD): − 0.44 [95%confidence interval (CI): − 0.84, −0.04], p = 0.03), waist circumference (MD : −0.78 [95%CI:−1.45, −0.11], p = 0.02), fasting blood glucose (FBG) level (standardized mean difference (SMD): − 4.92 [95%CI:−6.87, −2.98], p < 0.001) and homeostasis model assessment of insulin resistance (MD : −0.45 [95%CI:−0.61, −0.3], p < 0.001) when compared to the placebo group. Obese patients on antioxidant supplementation had lower levels of total cholesterol (SMD : −0.43 [95%CI:−0.84, −0.02], p = 0.04), triglycerides (SMD : −0.17 [95%CI:−0.31, −0.04], p = 0.01), low-density lipoprotein (SMD : −0.15 [95%CI:−0.29, −0.01], p = 0.03), malondialdehyde (SMD : −1.67 [95%CI:−2.69, −0.65], p = 0.001), and tumor necrosis factor-alpha (SMD : −0.29 [95%CI:−0.56, −0.02], p = 0.03), respectively, when compared to the placebo group. In addition, obese patients with antioxidant supplementation had higher levels of high-density lipoprotein (SMD : 0.25 [95%CI : 0.03, 0.46], p = 0.03) and superoxide dismutase (SMD : 1.09 [95%CI : 0.52, 1.65], p < 0.001) when compared to the placebo group. Antioxidant supplementation had no effects on other analyzed parameters including waist–hip ratio, leptin, fat mass, interleukin-6, C-reactive protein, alanine transaminase, and aspartate transaminase in obese patients. Conclusion The meta-analysis results indicated that antioxidant supplementation exerted potential beneficial effects in obese patients by regulating FBG, oxidative stress, and inflammation, whilst more high-quality studies are required to confirm these effects. The present study may provide important insights for the treatment of clinical obesity and obesity-associated complications.
Flatness tracking control scheme of rehabilitation exoskeleton robot with dynamic uncertainties

Artificial limbs are new robotic devices created to help stroke victims in the rehabilitation process. In this article, we focus our work on applying passive, active or assistive control strategies to provide a physical assistance and rehabilitation by a 7-degree-of-freedom exoskeleton robot with nonlinear uncertain dynamics and unknown bounded external disturbances due to the robot user’s physiological characteristics. The flatness controller combined with time-delay estimation is designed for the 7-degree-of-freedom exoskeleton robot called ETS-MARSE (Ecole de Technologie Supérieure—Motion Assistive Robotic-exoskeleton for Superior Extremity) in order to ensure a passive rehabilitation exercises with a high level of tracking accuracy and robustness against the uncertainty constraints. The stability analysis of such systems is proven using the Lyapunov–Krasovskii functional theory. This approach is illustrated by experimental results with healthy human to highlight the efficiency of the suggested controller scheme.
Autenticação em HTTP Baseada em Desafio-Resposta

Nós descrevemos a implementação de um protocolo desafio-resposta para uso em servidores e navegadores Web que prescinde do modo de autenticação em resumo padronizado pelo HTTP. Esta implementação utiliza primitivas (números pseudo-randômicos, funções resumo) facilmente implementáveis em servidores Web e permite a um desenvolvedor de aplicações Web manter sua própria base de informações de autenticação.
Assessing Levels of Competences, Knowledge and Attitudes of Nursing Internship Students Regarding Elderly Care

Background: Nowadays, demographic shifting in the growth of elderly people becomes a challenge that faces the whole world, as it is associated with aging consequences, multiple comorbidities and cognitive impairment. Therefore, elderly needs comprehensive competent skilled nursing care. Aim of the study was to assess levels of competences, knowledge and attitudes of nursing internship students toward elderly care. Design: A descriptive study design. Setting: This study was conducted at Tanta University Hospitals through Internship Follow up Unit of Nursing Faculty. Study subjects: All nursing internship students (345) whom affiliated to Tanta Nursing Faculty in the internship year 2021/2022. Tool : A structured questionnaire tool including personal data, Nurse Competence in Care Home Scale (NCCHS), Knowledge about Older patients Quiz for nurses (KOP-Q) and Kogan‟s Attitude Towards Old People Scale (KAOP)KAOP was used. Results : Two thirds 66.7% of nursing internship students had un- satisfactory competences regarding nursing care of elders. 87.2% of them had negative attitude toward elderly care. However, more than half of them (60.6%) had good knowledge score. There were significant negative correlation between total attitude, competencies and knowledge scores. Conclusion and recommendation: Although more than half of nursing internship students had good knowledge score, about two thirds of them had unsatisfactory competence and the majority of them had negative attitude toward elderly care. Therefore , Competencies, should be incorporated into specific, stand-alone courses focusing on care of the older adult, as well as integrated throughout the curriculum with emphasize on building positive attitude towards caring and working with elders.
Study of the response to isolated muons from collisions of the ATLAS Tile Calorimeter’s gap/crack cells

This thesis presents a calibration study of the ATLAS Tile Calorimeter’s gap/crack cells, using isolated muons from pp collisions at a center of mass energy of √ s = 7 TeV and an integrated luminosity of 1 fb−1. Muons, as minimum ionising particles, deposit a welldescribed amount of energy in the calorimeter. Therefore, they can be used to study the agreement between the measured and expected response. The W → μν events are selected using high level triggering, after which pion decay remains the main background. Dedicated studies on the TileCal calibration systems have shown that the response of the channels is time-dependent and therefore needs to be monitored. A method is proposed to determine detector modules that are miscalibrated, allowing no more than 3σ deviation from the Monte Carlo predictions. The so-called TileCal Unified Calibration Software has been improved to monitor the calibration status of the detector over time, incorporating the different calibration systems. Miscalibrations should be corrected for.
The Use of Hydrolyzed Palm Kernel Cake After Addition by Buffalo Rumen Fluid Enzymes on Growth Performances and Relatively Organ Weight of Broilers

This study aims to utilize a sufficient amount of palm kernel cake (PKC) and buffalo rumen fluid as a source of enzymes to improve the quality of PKC that can be used in broiler feed. The study was conducted in two stages. The first stage was to test the level of buffalo rumen fluid enzyme at various doses (0.0%, 0.75%, 1.5%, 2.25%, and 3.0% (v/w) in PKC incubation to measure dry matter (DM), organic matter (OM), crude fiber (CF), and dissolved glucose total (DGT) contents as hydrolyzed PKC. The second stage was to determine the usage level of hydrolyzed PKC in broiler feed. A total of 288 DOC MB202 strains were randomly allocated to one of five treatments with four replicated cages of 12 birds in a completely randomized design. Treatments were the various level of hydrolyzed PKC as following: 0%, 6%, 12%, 18%, 24%, and 30%. The variables were feed consumption, body weight gain (BWG), feed conversion ratio (FCR), final body weight (FBW), carcass, and digestive organs weight. The level of buffalo rumen fluid enzymes had a significant effect on DM, CF, and DGT content, while it was not significant on OM. The optimum level was 2.25% and it was used in the second stage. The use of hydrolyzed PKC up to 18% was not different (P>0.05) in BWG, FCR, and FBW compared to controls. The use of hydrolyzed PKC up to 24% decreased BWG, FCR, and FBW, but feed consumption did not differ (P>0.05) compared to control. Carcass and digestive organ weight were not affected (P>0.05) by the treatment. It can be concluded that the incubated buffalo rumen fluid enzymes at a level of 2.25% could improve the quality of PKC. The use of hydrolyzed PKC could be applied up to 18% without affecting the performance of broilers
Skin-Integrated Haptic Interfaces Enabled by Scalable Mechanical Actuators for Virtual Reality

The very recent concept of metaverse highlights the importance of virtual reality (VR) and augmented reality (AR), which associates with a wide variety of applications in entertainment, medical treatment, and human–machine interfaces. The current VR/AR technologies mainly rely on visual interaction, while immersive experience in VR and AR highly demands sensational feedback, such as haptic and temperature with noticeable quality in wearable or even skin-integrated formarts. In this article, we report a wearable and flexible haptic interface based on electromagnetic vibrotactile actuators with high wearability and stability. By adopting double layers of copper (Cu) coils at the top and bottom of the magnetic disc, an enhanced electromagnetic field can be generated. Additionally, the intensity of the haptic feedback can be modulated according to sensed pressure in the virtual world by adjusting the value of power input and frequency. The actuator exhibits high stability and tolerance upon environmental, cyclic, and impact resistance tests. Finally, the actuators are developed into the soft VR interfaces for mounting on forearms, fingers, and hands to verify their superiority over conventional haptic actuators in the aspects of performance and applications.
Simulation of collective pursuit‐evasion behavior with runtime situational awareness

We present a simulation method of pursuit‐evasion behaviors between different herds with runtime situational awareness. We model the collective movement of predators and prey in the hunting process based on an improved Boid model and the finite state machine involving multiple perception factors about the situations. Taking wolves hunting caribous as an example, our method not only simulates the collective behavior, but also realizes individual intelligent behaviors consistent with the observations. We conducted intensive experiments, and the results show that our method can simulate more realistic pursuit‐evasion behavior under different testing scenarios with a variety of parameters. Our method can be easily transferred to the theoretical study of collective behaviors of other herds.
Molecular Development of Placenta and Its Relationship with Preeclampsia and Fetal Growth Restriction

Preeclampsia (PE) is the leading causes of maternal death worldwide as well as a significant cause of fetal morbidity and mortality, including fetal growth restriction (FGR). The concept that PE and FGR shared a common etiology is widely accepted, i.e., the maladaptive response to the impaired placentation. Normal placentation is the result of dynamic integration of cell proliferation, differentiation, and migration, in which trophoblast cells play a crucial role. Impaired trophoblast invasion into the maternal decidua leads to a decrease in uteroplacental blood flow and changes in intervillous hemodynamic. The dynamic interaction of these process with maladaptive decidual immune response, impaired cytokines and angiogenic factors regulation, and oxidative stress will lead into the clinical manifestation of PE and/or FGR.
Ultrasensitive Detection of Multidrug-Resistant Mycobacterium tuberculosis Using SuperSelective Primer-Based Real-Time PCR Assays

The emergence of drug-resistant tuberculosis is a significant global health issue. The presence of heteroresistant Mycobacterium tuberculosis is critical to developing fully drug-resistant tuberculosis cases. The currently available molecular techniques may detect one copy of mutant bacterial genomic DNA in the presence of about 1–1000 copies of wild-type M. tuberculosis DNA. To improve the limit of heteroresistance detection, we developed SuperSelective primer-based real-time PCR assays, which, by their unique assay design, enable selective and exponential amplification of selected point mutations in the presence of abundant wild-type DNA. We designed SuperSelective primers to detect genetic mutations associated with M. tuberculosis resistance to the anti-tuberculosis drugs isoniazid and rifampin. We evaluated the efficiency of our assay in detecting heteroresistant M. tuberculosis strains using genomic DNA isolated from laboratory strains and clinical isolates from the sputum of tuberculosis patients. Results show that our assays detected heteroresistant mutations with a specificity of 100% in a background of up to 104 copies of wild-type M. tuberculosis genomic DNA, corresponding to a detection limit of 0.01%. Therefore, the SuperSelective primer-based RT-PCR assay is an ultrasensitive tool that can efficiently diagnose heteroresistant tuberculosis in clinical specimens and contributes to understanding the drug resistance mechanisms. This approach can improve the management of antimicrobial resistance in tuberculosis and other infectious diseases.
EARLY CHILDHOOD PARENTING: THE ROLE OF PARENTAL MINDFULNESS AND COPARENTING COMPETENCE IN PARENTAL WELL-BEING

Parents' well-being are significant things. Well-being is not only counted for parents’ physical, emotional, and mental conditions as an individual, it also has enormous influences on various aspects of children's development. Parents tend to face challenges, difficulties, and pressures during parenting, especially when caring for children in early childhood. This study aims to determine the role of parental mindfulness and coparenting competence in predicting parental well-being. Three hundred and thirty-one parents of children in early childhood participated in this study. The researchers used the convenience sampling method. Parents completed the Parental Well-Being Scale, Bangor Mindful Parenting Scale, and Coparenting Competence Scale. The result of multiple linear regression analysis indicated that parental mindfulness and coparenting competence have significant roles in predicting parental well-being. The coefficient of determination showed that parental mindfulness and coparenting competence simultaneously explained 15.7% of the parental well-being variance. There are no significant differences in parental well-being between fathers and mothers. This finding indicates the importance of parenting competence in order to improve parental well-being.
Taking N to zero with S matrices

Interesting physical results can be obtained from sigma models by taking the number of fields N to zero. I discuss how one can make sense of this limit by using exact S matrix techniques. I review how this can be done for the case of self-avoiding polymers, and speculate on the application to the replica limit of disordered systems.
Flexible electrodes for non-invasive brain–computer interfaces: A perspective

At the present time, brain–computer interfaces (BCIs) are attracting considerable attention due to their application potential in many fields. In this Perspective, we provide a brief review of flexible electrode technologies for non-invasive BCIs, mainly including two types of the most representative flexible electrodes: dry electrodes and semi-dry electrodes. We also summarize the challenges encountered by the different kinds of electrodes by comparing their strengths and weaknesses in terms of manufacturing scalability, applicability, comfort, contact impedance, long-term stability, and biocompatibility. In addition, we describe some advanced configurations and suggest potential applications for non-invasive BCIs based on flexible electrodes and consider future development prospects.
Floating potential method using a thermionic emissive probe including an ionizing and collisional presheath

This article studies the interaction of an argon plasma with an emissive probe considering the effect of both ionization and ion–neutral collisions. The floating potential is determined from the I–V characteristic curves as a function of the probe temperature, neutral gas pressure and plasma electron temperature. This potential increases with increasing probe temperature until reaching the plasma potential, exceeding the saturation value previously indicated by other authors. Finally, a relationship between the plasma electron temperature and the probe temperature at which the floating potential reaches the plasma potential is shown, demonstrating that these probes can be used for diagnosis of the plasma electron temperature.
Control difuso tipo dos en convertidores de potencia

Este artículo muestra el control del voltaje de salida de un convertidor de potencia tipo boost, los convertidores son sistemas conmutados, por lo cual se eligió un control discontinuo de modos deslizantes, este tipo de control emplea un control equivalente que puede hacer uso del modelo matemático del sistema, y un control discontinuo basado en una función del error de medición. Ante la incertidumbre paramétrica en el circuito y situaciones prácticas pasadas por alto en el modelo del convertidor, como son las caídas de voltaje en el interruptor y el diodo, se emplearon modos deslizantes difusos adaptables, de este modo no es necesario contar con el modelo matemático del convertidor. Una alternativa de justificar la arbitrariedad en el diseño de los conjuntos difusos es emplear conjuntos difusos tipo dos, con los que se abarcarían diferentes formas de conjuntos en la partición difusa, por lo que este tipo de conjuntos es empleado en este esquema de control.
Physics-Based Performance Optimization of Fiber-Optic Interferometric Hydrophone With Push–Pull Mandrel Structure

The influence of the parameters of the elastic mandrel on the performance of fiber-optic interferometric hydrophone with a push–pull structure comprised of two concentric cylindrical shells is investigated through systematic solid mechanical analysis. The structural and material parameters considered include Young’s modulus, Poisson ratio, the thickness, length, and outer radius of the elastic tube. The result shows that a higher sensitivity of the push–pull fiber-optic hydrophone can be obtained with a lower Young’s modulus and Poisson ratio, and a thinner wall, larger radius, and longer length of the elastic tube, accompanied by a lower fundamental resonant frequency. Therefore, obtaining an optimal performance of the push–pull fiber-optic hydrophone often entails a tradeoff between material properties and geometric parameters. A family of prototypical fiber-optic hydrophones with different structural parameters are fabricated and examined experimentally, corroborating the results of solid mechanical [finite-element method (FEM)] analysis, among which the push–pull fiber-optic hydrophone with the optimal parameters has demonstrated notably improved acoustic frequency response characteristics and a reduced minimum detectable pressure (MDP).
Quantum attractors of generalized Gauss-Bonnet dark energy

The influences of quantum effects on the structure of the phase-space of generalized Gauss-Bonnet theory, introduced by the Lagrangian F(R,G), have been studied. G is the Gauss-Bonnet invariant, and the quantum effects are described via the account of conformal anomaly. It has been shown that the quantum effects change many aspects of the attractors of F(R,G) gravity models in the R-H plane, including the location of the attractors, the number of them and their stability properties. These variations are not, in general, from the type of small perturbations, but instead, it can induce the great, so not ignorable, variations which have root in the "singular perturbation" nature of this effect. In other words, one can not ignore the quantum corrections and must be always considered. The influences of the perfect barotropic fluids on this problem have been studied, and it has been shown that this kind of matters do not alter the quantum effects. It has been shown that the classical contribution of the coupled-quintessence model, which is responsible for inducing the quantum effects, is of this type, that is a perfect barotropic fluid, and therefore can not change our results.
The Progress of the SDGs Research

The global Sustainable Development Goals (SDGs) provide an evidence-based policy for sustainable development planning and programming to halt poverty, gain prosperity and protect the planet by 2030. The SDGs consist of 17 goals and 169 targets that emphasize the balance between economic, social and environmental sustainability. Since the framework launched in 2015, there is growing international policies, practices, innovations, assessments and research activities related to such issues
MORTALITY INCIDENCE OF SYSTEMIC LUPUS ERYTHEMATOSUS IN DR. SOETOMO GENERAL HOSPITAL SURABAYA

Introduction: Systemic Lupus Erythematosus (SLE) is a chronic systemic autoimmune disorder involving a multi-organ system. Fatal autoimmune causes usually characterize SLE with a high mortality rate. In 2012 the mortality rate of SLE in Dr. Soetomo General Hospital Surabaya was 22.9%. Recently covered data hasn’t been published. Methods: This study is a descriptive retrospective. The aim is to evaluate the mortality rate using the medical records of SLE patients. All SLE patients were admitted to Dr. Soetomo General Hospital Surabaya from May 2016 to May 2017. Patients’ characteristics, disease activity, and causes of death are collected. Results: There are a total of 176 patients, with 93.2 % female, with a mean age of 29.5 and a mean duration of illness of 20 months. There were 39 deaths (22.2%), with the leading causes being a respiratory failure (33.3%), septic shock (28.2%), and undetermined (23.1%). Low levels of C3 (69.2%)andC4(69.2%)are the most common immunology profile in deed patients. The therapy used the most is the corticosteroid pulse dose(46.2%). Conclusion: It concludes that the decrease in the mortality rate of SLE in Dr. Soetomo General Hospital, Surabaya is 0.7% from 2012 to 2017.
An error indicator for two-dimensional elasticity problems in the discrete least squares meshless method

An error indicator of the discrete least squares method (DLSM) for 2D elastostatic problems is presented. In the DLSM, the problem domain is discretized by distributed field nodes. The field nodes are used to construct the trial functions. The moving least-squares interpolant is employed to construct the trial functions. The least-squares technique is used to obtain the solution of the problem by minimizing the summation of the residuals for the field nodes. The error indicator is readily computed from the residual of the governing differential equation. It is demonstrated, through some elastostatic problems, that the error indicator reflects the exact error.