Miracle-dz/UniFAR-FTUs huggingface dataset:
Pristine Nanocarbon-based Fullerene-like Material Toxicity and Biocompatibility (Part 2 in the series: Will Nanocarbon Onion-Like Fullerenes Play a Decisive Role in the Future of Molecular Medicine?)

Outcomes of in vivo and in vitro biological studies of nanocarbon materials are varied and at times contradictory. Research suggests that nanocarbon materials (including pristine fullerenes) pose a risk to living systems. However, overall outcomes using pristine single- and multi-walled nanocarbon fullerenes have been favorable and suggest biocompatibility. Variability in research outcomes results from not only the interaction of the material with biological systems but also the quality and consistency of fullerene material (such as, inconsistencies in purity, structure, processing, and functionalization of fullerenes) that produce differences in characterization and properties even within the same batch. Due to the omnipresence of nanocarbon-based material in the environment, it should be considered that biological systems long ago developed ways to detoxify and or exploit nanocarbon-based material. The main focus of this paper is the factors contributing to relative biocompatibility and toxicity of fullerene material and the variations in their absorption, biocoronation, degradation, and elimination. A review of more current research suggests that theoretical or in vitro generalizations regarding any biological hazards of fullerene material are speculative and inaccurate; their biological interactions should be considered and assessed in vivo. If factors affecting the relative toxicity of fullerenes and consistency in their production are addressed, valuable research could move forward to explore and unleash the potential applications and benefits of fullerenes in living systems.
TGF- b Family Signaling in Neural and Neuronal Differentiation, Development, and Function

Signaling by the transforming growth factor b (TGF- b ) family is necessary for proper neural development and function throughout life. Sequential waves of activation, inhibition, and reactivation of TGF- b family members regulate numerous elements of the nervous system from the earliest stages of embryogenesis through adulthood. This review discusses the expression, regulation, and function of TGF- b family members in the central nervous system at various developmental stages, beginning with induction and patterning of the nervous system to their importance in the adult as modulators of inﬂammatory response and involvement in degenerative diseases.
Mass Apprasial With A Machine Learning Algorithm: Random Forest Regression

— Traditional methods in many areas have been replaced by modern methods known as machine learning with the rapidly developing technology and innovations in science. One of these areas is real estate valuation (appraisal) area. Real estate appraisal can be conducted on a single real estate as well as appraisal of more than one real estate together, which is called as mass appraisal, is possible. In this study, a mass appraisal is performed by a Random Forest Regression method, and the results were evaluated. For this purpose, data of 189 flats expected real value and their 13 variables were collected in Yenimahalle, Ankara. 75% of these data were used as training data and 25% as test data. According to the results, a difference of at minimum 600 TL, maximum 60.000 TL and averagely 25.000 TL were observed between the predicted value by the Random Forest regression and the expected real value. According to these results, random forest regression is a successful method in mass appraisal, and it is observed that valuation with different machine learning methods such as random forest regression has a positive effect on time and labor force comparing with valuation of real estate by traditional methods individually.
Common Errors in the Interpretation of the Ideas of The Black Swan and Associated Papers

The point of The Black Swan is that both empirical knowledge (i.e. extrapolating statistics) and a priori theories fail in the tails and it is vital to "robustify" against it using the concepts of "the fourth quadrant". The point has been garbled by members of the economics establishment that claim mistakenly "we know that" and "we know about fat tails" or "power laws". This is both wrong and not my point. The paper presents corrections to the misperceptions.
Influenza vaccine production technologies: past, present and future

Influenza is a constantly evolving global health threat that leads to substantial morbidity andmortality particularly in vulnerable populations at either end of the age spectrum. Society has responded by creating a global public-private system that involves constant surveillance, candidate virus generation, and release reagent generation linked toworldwide influenza vaccine manufacturing capabilities. It was initially recognised that influenza circulates as multiple antigenically distinct subtypes, which led to the generation of vaccines containing multiple influenza strains. The first and still current major process used for influenza vaccine production is infection of embryonated hen’s eggs with influenza virus. While this approach was a true advancement, some shortcomings such as lack of vaccine match to circulating strains due to egg adaptation and production capacity limitations have led to recent innovations inmammalian cell production and synthetic technologies aimed at further improving global influenza responses.
The Journal of Toxicological Sciences

In the present study, we investigated the effects of lead (Pb) and ascorbic acid co-administration on rat cerebellar development. Female rats were randomly divided into the following groups: control, Pb, and Pb plus ascorbic acid (PA) groups. From one week prior to mating, female rats were administered Pb (0.3% Pb acetate in drinking water) and ascorbic acid (100 mg/kg, oral intubation). The chemical administration was stopped on postnatal day 21 when the morphology of the offspring’s cerebellum is similar to that of the adult brain. The blood Pb level was significantly increased following longterm Pb exposure. Ascorbic acid reduced Pb levels in the dams and offspring. Nissl staining demonstrated that the number of Purkinje cells was significantly reduced following Pb exposure, while ascorbic acid ameliorated this effect in the cerebellum of the offspring. Calcium-binding proteins, such as calbindin, calretinin, and parvalbumin were commonly expressed in Purkinje cells, and Pb exposure and ascorbic acid treatment resulted in similar patterns of change, namely Pb-induced impairment and ascorbic acid-mediated amelioration. The gamma-aminobutyric acid transporter 1 (GABAT1) is expressed in the pinceau structure where the somata of Purkinje cells are entwined in inhibitory synapses. The number of GABAT1-immunoreactive synapses was reduced following Pb exposure, and ascorbic acid co-treatment prevented this effect in the cerebellar cortex. Therefore, it can be concluded that ascorbic acid supplementation to mothers during gestation and lactation may have potential preventive effects against Pb-induced impairments in the developing cerebellum via protection of inhibitory neurons and synapses.
Transfer efficiency of a misalignment of resonators in MR‐WPT for a laptop computer with SGR

This study analyzed the effect of a misalignment of resonators on a magnetic resonant wireless power transfer (MR‐WPT) for a practical laptop computer with a slit ground resonator (SGR). MR‐WPT can be used in many applications for charging mobile devices, such as laptop computers, tablet PCs, and smartphones. We proposed a wireless power‐charging system from a transmitter on a desk or table to the receiver imbedded on a laptop computer. However, transfer efficiency decreased because of the misalignment between the movable receiver and the transmitter. This misalignment could have undue influence on the transfer power of MR‐WPT. To verify the effect of a misalignment of resonators on MR‐WPT, we simulated mutual inductance according to the misaligned distance between the transmitter and the receiver. Moreover, we experimentally proved this relationship through a practical laptop model with an SGR in MR‐WPT.
Patients undergoing peritoneal dialysis: association between nursing diagnoses and their components

Objective: To analyze the association between nursing diagnoses and their defi ning characteristics, related or risk factors for patients on peritoneal dialysis. Methods: Content validation study with six nephrologist nurses, who participated in the study as experts. The focus group technique was used. Logistic regression was used for data analysis. Results: For the four nursing diagnoses studied, was identifi ed an association with its components as follows. Fatigue: anemia, insuffi cient energy and verbalization of a sustained exhaustion; Impaired walking: impaired ability to navigate curbs, impaired ability to climb stairs and insuffi cient muscle strength; Constipation: insuffi cient fl uid intake, insuffi cient physical activity, pain with defecation, hard and formed stools; Excess fl uid volume: compromised regulatory mechanisms, azotemia, intake exceeds output, weight gain over short period of time, and electrolyte imbalance. Conclusion: The analyzed diagnoses integrate the following domains: activity/rest, elimination and exchange and nutrition, and are
A Mississippian-aged embolomerous early tetrapod from Point Edward, Nova Scotia, Canada

Vertebrate Anatomy Morphology Palaeontology 6:1–57 2 Danielle Fraser, Canadian Museum of Nature Jordan Mallon, Canadian Museum of Nature Hillary Maddin, Carleton University Michael Ryan, Cleveland Museum of Natural History Host Committee Canadian Society of Vertebrate Palaeontology 2018 Abstracts
Biochemistry and Microbiology, 361- 372 Production and Evaluation of Alpha-Amylase Produced From Bacillus Amyloliquefaciens

This research was carried out to determine the optimal environmental and nutritional factors for amylase production and its activity by bacterial strains Bacillus amyloliquefaciens as well as to evaluate the kinetic characterization of the produced α-amylase. From the obtained results showed that the optimum pH, inoculum size, fermentation period, incubation temperature, carbon and nitrogen sources for produced glucose and amylase activity were 7.0, 1500 μl /ml, 72 h, 37 o C, starch and tryptone, respectively when the basal broth medium was used as a fermentation medium rather than the using of starch broth medium for the production of α-amylase. In addition, data showed that the shaking method was better than the static one for amylase production. Moreover, the optimal conditions for fermentation process gave a higher records of produced glucose and amylase activity rather than each factor individually. The values of amylase activity, protein content and specific amylase activity were 697.60 U/ml, 57.14 mg/ ml and 12.21U /mg protein, respectively. Concerning the factors affecting on produced α- amylase activity were evaluated. From the obtained results , the optimum temperature and pH values of the produced α-amylase from Bacillus amyloliquefaciens were found to be 65 o C and 6.0, respectively and the reaction activity were reached their maximum values were 15.46 U/ml /min for temperature and 18.8 U/ml/min for pH. The V max and K m values of the production enzyme under investigation were determined by incubation fixed amount of enzyme with varied concentrations of soluble starch at 65 o C , pH 6.0 and 15 min were 32.3 U/ml/min and 1.596 ml/100 ml, respectively . On the other hand, the obtained resulted indicated that the metal ion concentration of 1 mM had a greater effect on enzyme activities than 5 mM. The relative activities of the produced α-amylase were activated by Fe 3+ , Cu 2+ and Ca 2+ at 1 mM, but strongly inhibited by Mn 2+ and Ni 2+ at both 1 mM and 5 mM concentrations.
Ballistic dispersive shock waves in optical fibers

We experimentally and numerically report on the formation of ballistic dispersive shock waves that mimic superfluid behavior in optical fibers. The shock wave is triggered by a strong nonlinear phase shift induced by a high power pump pulse on a cross-polarized continuous-wave probe field, and it exhibits a central void surrounded by two oscillating fronts moving away from each other with opposite velocities. The impact of disorder in the continuous-wave background as well as the difference of group-velocities between the two orthogonally polarized waves is also investigated. Our experimental observations are in very good agreement with theoretical and numerical predictions derived from the Manakov model. on the CW landscape as a function of the pump peak-power. Here a single initial CW laser is used for both waves (null walk-off configuration). The power variation is directly performed with a remote programmable attenuator, thus ensuring an efficient stability of the setup, especially on polarization states. Moreover, the full automatization of our experimental platform enables us to accumulate up to 150 measurements in a very short time scale, providing a perfect stability during the whole shock
Composition of the Aliphatic Components of Suberin of the Endodermal Fraction from the First Internode of Etiolated Sorghum Seedlings'

The stems from etiolated s s of bkoior were s ted into emal nd o l f by manually removing the stekn from the cortex. The epd fiacti was shin to contain a lpd polymer whose me ic composition was characteristic of cutin with dibydroxyhexadecanoi acid as a majompoe nt (25%). endodermal fraction contand a d polymer whose momec ompositio was characteristic of suberin: hexadecanoic acid 12%, oct ol 6%, octa- decenoic acid 23%, w-hydroxybexadecaaoc acid 17%, hexa acid 8%, w-hydroxyoctadecenokc acid 8%, and oc dl acid 12%. TIIs endodermal polymer is thoght to be the suberin compet of the Casparian band.
Significance of Electronic Picture Story Book in TEYL

In this digital era, the product of technology such as tablet PC, iPad, Smartphone, computer, internet access and electronic book reader are close in our daily life. This article highlights the benefit of using electronic picture story book. Electronic picture story book is one of the tools that can be used in teaching reading for young learners in the literacy activity. It is development of modern education which integrates with technology. Electronic picture story book can be helpful as a supplement to the language.Young learners have their own perspective in comprehending a message. They have different way to transfer what they have in their mind. By having visualization, young learners will more enthusiastic and interested to read in order to get good stimulation through their imaginations. Electronic picture story book could be considered an aggregation of multi-pages, responsive and lively multi-media (includes information of characters, picture, voice , sounds effects, music, animation, etc). Visual aids in electronic picture story book are helpful for getting the information and mental representation. Electronic picture story book could become innovative and creative as their guide in the literacy activity. This article offers the potential ways to build children’ reading enthusiasm through electronic picture book.
The Forgotten Serine A CRITICAL ROLE FOR Ser-203 5.42 IN LIGAND BINDING TO AND ACTIVATION OF THE b 2 -ADRENERGIC RECEPTOR*

Previous work in the b 2 -adrenergic receptor demon- strated critical interactions between Ser-204 and Ser-207 in the fifth membrane-spanning segment and the meta -OH and para -OH, respectively, of catecholamine agonists (Strader, C. Candelore, Hill, Sigal, S., A. (1989) J. Biol. Chem. 264, 13572–13578). Using the substituted cysteine accessibility method in the b 2 -adrenergic receptor, we have found that in addition to Ser-204 and Ser-207, Ser-203 is also accessible on the surface of the binding-site crevice and is occluded by bound agonist. Mutation of Ser-203 to Ala, Val, or Cys reduced the binding affinity and adenylyl cyclase-activating potency of agonists containing a meta -OH, whereas their affinities and potencies were largely preserved by mutation of Ser-203 to Thr, which maintained an OH at this position. Thus both Ser-203 and Ser-204 appear to interact with the meta -OH of catecholamines, perhaps through a bifurcated H bond. Fur-thermore, the removal of
Dosimetric Comparison of IMRT with 3D-CRT Regarding Their Contribution to the Treatment Plan Optimization Using Rando Phantom with a Realistic Lung Cancer Radiotherapy Treatment Planning

Introduction: This study compared a three-dimensional conformal radiation therapy (3D-CRT) with a recently implemented intensity modulation radiation therapy (IMRT) technique performed in the irradiation of lung cancer. The objective of this study is to demonstrate the dosimetric advantages of IMRT in target coverage, dose homogeneity, and reducing toxicity. Material and Methods: Depth point doses were compared as calculated by the Varian Eclipse treatment planning system (TPS) on virtual created patient and experimentally measured by thermoluminescence (TL) dosimetry. For treatment planning the same lesion of the real case with different volumes and structures contouring details were created on Rando anthropomorphic phantom computed tomography (CT) data. Dose measurement was performed by calibrated thermoluminescent detectors. Results: The difference between experimental TL measured doses and calculated doses in both techniques show mean values of ~3% (IMRT) and ~1% (3D-CRT) for high dose (>0.55Gy) and ~7% IMRT and 6.5% (3D-CRT) for low dose (<0.55Gy). All IMRT optimized plans improved the heart (-28.3%), the spinal cord (-25.3%), and the left lung (-41.55%) sparing significantly, compared to the 3D-CRT plans. The optimized dose-volume histograms, the dose covering indices, and the dose profile across heterogeneity interfaces showed a significant improvement in dose conformity by IMRT. Conclusion: These findings demonstrate well that TL dosimetry when combined with suitable point dose measurement procedures can efficiently be used as an external and independent dose audit for the comparison between 3D-CRT and IMRT. IMRT with its dose-volume optimization algorithm can achieve a treatment plan quality in lung cancer radiotherapy unachievable by 3D-CRT.
EFFECT OF INVENTORY TARGET AND REPLENISHMENT DELAY ON DYNAMIC EOQ

is model used to the optimal for an based on the cost of ordering, storing and shortage. Therefore, we propose dynamic EOQ consisting of the variables, which have interrelation, delay factor, feedback loop, and as a closed system in the system dynamics model. Through this model, we can do various scenario to get the minimum total cost associated with policies that can be done on variables controlled (exogenous variable of a dynamic system). However, we only limit the two scenarios to get the minimum total cost, which is the inventory target and delay of replenishment. Based on two scenarios, this article can show the simulation output as the graph of variables (the dynamic behavior) and clarified by statistical data (maximal value, minimal value, total, deviation standard, and average) that can be used to choose the policy to achieve the minimum total cost of dynamic EOQ. In this article, scenario increasing inventory target results in the decrease of total cost less than the decreasing delay of replenishment.
ORIGINAL ARTICLES. PHYSICAL REHABILITATION Correction of Carbohydrate Metabolism by Means of Physical Therapy of Patients with Metabolic Syndrome

Correction of carbohydrate metabolism means of therapy of Abstract Purpose: to investigate the characteristics of carbohydrate metabolism indicators in patients with metabolic syndrome before the beginning of rehabilitation effects as well as to trace the dynamics of indicators in the process of application of our physical therapy comprehensive program. Material and methods. The survey involved 70 women with metabolic syndrome, who were divided into the main (MG) (35 women) and control (CG) (35 women) groups with the average age in the MG 31.49±0.71 -year-olds, in the CG – 31. 06±0 . 57 year-old. In the main group, a physical therapy program was applied for patients with metabolic syndrome, which includes a hypo caloric diet with a hypolipidemic focus; therapeutic massage according to the method of patients alimentary-constitutional obesity; medical gymnastics using elements of sports-oriented aerobics and special physical exercises based on Pilates gymnastics using fitballs and expanders; morning hygienic gymnastics; limited walking in combination with breathing exercises, taking into account the activity of the autonomic nervous system. Result. As a result of a comprehensive and developed physical therapy program that was justified and applied for 4 months for patients with metabolic syndrome, the studied carbohydrate metabolism parameters changed significantly. Main group women showed significantly improved indicators of glycemia on empty stomach: from 8.85 ± 1.54 to 5.98 ± 0.81 mmol·l -1 , glycemia after eating: from 11.47 ± 1.85 to 7.68 ± 0.86 mmol · l -1 and reached the target levels of diabetes compensation and diagnostic criteria for the metabolic syndrome. Conclusions: physical exercises contribute to the improvement and normalization of carbohydrate metabolism. They restore adaptation to physical exertion and normalize the function of the cardiovascular system, motor activity and psychoemotional state as well.
Dual task performance and executive function in physically under active and physically active elderly: A comparison I nternational J ournal of A llied M edical S ciences and C linical R esearch (IJAMSCR)

Background Effect of being physically active on motor and cognitive function is well known. Indirect effect of being physically active on dual tasking needs to be explored. Aim & Objectives To compare dual tasking and executive function in physically active and underactive elderly. Method 124 Elderly were divided in to physically active and non-active using Rapid Assessment of Physical Activity (RAPA) scale and assessed for their Dual tasking skills using TUG-Cog, TUG-motor. Data was analyzed using unpaired t test. Result Physically active elderly performed significantly better than underactive elderly on Tug cog ,manual in both groups (p<0.001) Conclusion Physically active elderly have better dual tasking skills than their physically underactive counterparts.
Evaluation of Anti-epileptic Activity of Lantana camara (Linn.) Flowers in Swiss Albino Mice

Globally, approximately 50 million people are being affected by epilepsy and nearly 80% occurring in the developing countries. The plant Lantana camara Linn. (Family: Lamiaceae) is native to the tropical regions of the America, Africa and Asia. It is found in Kumaun and Garhwal resign of Uttarakhand, India. The plant has been used for various ailments in traditional systems of medicines for the treatment of epilepsy, wounds, tumor, stomach-ache and inflammation. The present study was planned with an objective to evaluate anti-epileptic activity of Lantana camara flowers in mice. Maximum electric shock (MES) and Pentylenetetrazole induced (PTZ) model of epilepsy were employed in the present study. Amongst, the various extracts prepared viz., petroleum ether, chloroform, ethanol and aqueous, only ethanol and chloroform extract by successive solvent extraction method showed significant anti-epileptic activity in MES and PTZ model of epilepsy. Highest anti-epileptic activity (P < 0.05) was shown by ethanol extract at a dose of 200 mg/kg whereas chloroform extract showed moderate anticonvulsant effect at 200 mg/kg dose. The findings of present study lead to conclusion that ethanol extract of Lantana camara flowers showed potent anti-epileptic activity which scientifically, validates the traditional claim of Lantana camara for the treatment of epilepsy.