Miracle-dz/UniFAR-FTUs huggingface dataset:
Perturbed NK Cell Homeostasis Associated with Disease Severity in Chronic Neutropenia.

Neutrophils have been suggested to play a critical role in terminal differentiation of NK cells. Whether this is a direct effect or a consequence of global immune changes with effects on NK cell homeostasis remains unknown. Here, we used high-resolution flow- and mass cytometry to examine NK cell repertoires in 64 patients with neutropenia and 27 healthy age- and gender-matched donors. A subgroup of patients with chronic neutropenia showed severely disrupted NK cell homeostasis manifested as increased frequencies of CD56bright NK cells and a lack of mature CD56dim NK cells. These immature NK cell repertoires were characterized by expression of proliferation/exhaustion markers Ki-67, Tim-3 and TIGIT and displayed blunted tumor target cell responses. Systems-level immune mapping revealed that the changes in immunophenotypes were confined to NK cells, leaving T cell differentiation intact. RNA sequencing of NK cells from these patients showed upregulation of a network of genes, including TNFSF9, CENPF, MKI67 and TOP2A, associated with apoptosis and the cell cycle, different from conventional CD56bright signatures. Profiling of 249 plasma proteins showed a coordinated enrichment of pathways related to apoptosis and cell turnover, which correlated with immature NK cell repertoires. Notably, most of these patients exhibited severe-grade neutropenia, suggesting that the profoundly altered NK cell homeostasis was connected to the severity of their underlying etiology. Hence, although our data suggests that neutrophils are dispensable for NK cell development and differentiation, some patients displayed a specific gap in the NK repertoire, associated with poor cytotoxic function and more severe disease manifestations.
Web-Based Information Seeking Behaviors of Low-Literacy Hispanic Survivors of Breast Cancer: Observational Pilot Study

Background Internet searching is a useful tool for seeking health information and one that can benefit low-literacy populations. However, low-literacy Hispanic survivors of breast cancer do not normally search for health information on the web. For them, the process of searching can be frustrating, as frequent mistakes while typing can result in misleading search results lists. Searches using voice (dictation) are preferred by this population; however, even if an appropriate result list is displayed, low-literacy Hispanic women may be challenged in their ability to fully understand any individual article from that list because of the complexity of the writing. Objective This observational study aims to explore and describe web-based search behaviors of Hispanic survivors of breast cancer by themselves and with their caregivers, as well as to describe the challenges they face when processing health information on the web. Methods We recruited 7 Hispanic female survivors of breast cancer. They had the option to bring a caregiver. Of the 7 women, 3 (43%) did, totaling 10 women. We administered the Health LiTT health literacy test, a demographic survey, and a breast cancer knowledge assessment. Next, we trained the participants to search on the web with either a keyboard or via voice. Then, they had to find information about 3 guided queries and 1 free-form query related to breast cancer. Participants were allowed to search in English or in Spanish. We video and audio recorded the computer activity of all participants and analyzed it. Results We found web articles to be written for a grade level of 11.33 in English and 7.15 in Spanish. We also found that most participants preferred searching using voice but struggled with this modality. Pausing while searching via voice resulted in incomplete search queries, as it confused the search engine. At other times, background noises were detected and included in the search. We also found that participants formulated overly general queries to broaden the results list hoping to find more specific information. In addition, several participants considered their queries satisfied based on information from the snippets on the result lists alone. Finally, participants who spent more time reviewing articles scored higher on the health literacy test. Conclusions Despite the problems of searching using speech, we found a preference for this modality, which suggests a need to avoid potential errors that could appear in written queries. We also found the use of general questions to increase the chances of answers to more specific concerns. Understanding search behaviors and information evaluation strategies for low-literacy Hispanic women survivors of breast cancer is fundamental to designing useful search interfaces that yield relevant and reliable information on the web.
Oral Kaposi sarcoma development is associated with HIV viral load, CD4+ count and CD4+/CD8+ ratio

Background Kaposi’s sarcoma (KS) is an uncommon, multifocal and angioproliferative lesion, which demonstrates a poor prognosis. The aim of the present research was to explore the association of HIV viral load, CD4+ and CD8+ counts and the CD4+/CD8+ ratio on the risk of oral Kaposi’s sarcoma (KS) development. Material and Methods A total of 62 patients were retrieved from March 2008 to October 2020 from the files of two oral pathology centres. Clinical, laboratory and follow-up data were retrieved from their medical files. Poisson regression was used to explore the role of history of immunosuppression and its association with oral KS development. A P-value <0.05 was considered significant. Results Sixty-two patients were included in the present study (32 with oral KS and 30 with no presentation of lesions anywhere on the body). Patients with oral KS presented a mean age of 32.6 years, and male patients were more affected. The hard palate (15 cases; 46.8%) was the main anatomical site affected. The lesions were mostly presented as swellings (13 cases; 40.6%) and nodules (12 cases; 37.5%). Systemic manifestations were also observed, including candidiasis (4 cases; 12.5%), bacterial infection (3 cases; 9.3%), tuberculosis (3 cases; 9.3%), herpes simplex (3 cases; 9.3%) and pneumonia (3 cases; 9.3%). A significant correlation was observed between HIV viral load, CD4+ count and the CD4+/CD8+ ratio with oral KS development. Conclusions HIV viral load, CD4+ count and the CD4+/CD8+ ratio are associated with oral KS development. Key words:Cancer, oral, Kaposi’s sarcoma, diagnostic.
Application of social cognitive theory in weight management: Time for a biological component?

Despite the utility of social cognitive theory for facilitating individual behavior changes needed for initial weight loss, this model has been less effective in facilitating adherence to recommended lifestyle changes required for sustainable weight‐loss maintenance. One potential reason for the limited long‐term effectiveness of lifestyle interventions guided by this model is that the model does not consider the important influence that biology can have on weight‐relevant behaviors, during both weight loss and weight‐loss maintenance, via sensations of hunger and satiety and changes in energy metabolism (expenditure and fat oxidation). We describe here a proposed revision to social cognitive theory that allows for biological factors to exist in reciprocal determinism with behavioral, environmental, and personal factors, with the goal of creating a theoretical basis for lifestyle interventions with greater personalization in order to facilitate better long‐term adherence and improve weight‐loss maintenance.
Blood Glucose Monitoring and Sharing Amongst People With Diabetes and Their Facilitators: Cross-sectional Study of Methods and Practices

Background The last two decades have witnessed a burgeoning rise in the prevalence of diabetes globally. It has already reached epidemic proportions in Saudi Arabia, with reported high risk among women. As a result, diabetes monitoring and self-management programs are being highly prioritized for diabetes control and management. Objective To investigate measuring and sharing practices of the self-monitoring of blood glucose (SMBG) among patients with type 1 or 2 diabetes using insulin. Methods A cross-sectional study was conducted on a sample of 203 patients attending primary care clinics at a tertiary care center. The questionnaire assessed the measuring, recording, and sharing of SMBG practices of patients having diabetes with their physicians. The methods used for recording and sharing were categorized into paper-based and electronic-based. In addition, the determinants of the different methods used and frequency of sharing were analyzed. Results The overall monitoring prevalence was 95% (193/203), and 57% (117/203) of participants shared the SMBG results. Among the 193 individuals that performed self-monitoring, 138 (72%) performed daily monitoring, and 147 (76%) recorded their blood sugar levels. Almost 55% (81/147) used paper-based materials like notebooks and paper for recording, while the rest (66/147, 45%) used digital devices like laptops and smartphones. A shift towards the use of digital devices and smart applications was observed in patients below 50 years of age. The digitally recorded blood glucose measurements were being shared thrice more often than the recordings made on paper or in notebooks (OR [odds ratio] 2.8; P=.01). Patients >50 years of age (OR 2.3; P=.02), with lesser formal education, married (OR 4.2; P<.001), with smaller family size (OR 2.6; P=.01), having type 2 diabetes (OR 4.1; P<.001) and any comorbid conditions (OR 2.6; P=.01) were associated with higher odds of using paper-based sharing methods. Only the female gender and type 2 diabetes were associated with increased frequency of sharing, while uncontrolled diabetes, the presence of other comorbidities, and duration of diabetes did not show any influence. Conclusions Good monitoring and optimal sharing practices were found. Sharing using electronic devices can be emphasized. Diabetes self-management programs can incorporate the use of digital technology in training sessions. Digital literacy and its applications in health care may enhance SMBG practices resulting in better diabetes control.
Novel localizations of TRPC5 channels suggest novel and unexplored roles: A study in the chick embryo brain

Mammalian TRPC5 channels are predominantly expressed in the brain, where they increase intracellular Ca2+ and induce depolarization. Because they augment presynaptic vesicle release, cause persistent neural activity, and show constitutive activity, TRPC5s could play a functional role in late developmental brain events. We used immunohistochemistry to examine TRPC5 in the chick embryo brain between 8 and 20 days of incubation, and provide the first detailed description of their distribution in birds and in the whole brain of any animal species. Stained areas substantially increased between E8 and E16, and staining intensity in many areas peaked at E16, a time when chick brains first show organized patterns of whole‐brain metabolic activation like what is seen consistently after hatching. Areas showing cell soma staining match areas showing Trpc5 mRNA or protein in adult rodents (cerebral cortex, hippocampus, amygdala, cerebellar Purkinje cells). Chick embryos show protein staining in the optic tectum, cerebellar nuclei, and several brainstem nuclei; equivalent areas in the Allen Institute mouse maps express Trpc5 mRNA. The strongest cell soma staining was found in a dorsal hypothalamic area (matching a group of parvicellular arginine vasotocin neurons and a pallial amygdalohypothalamic cell corridor) and the vagal motor complex. Purkinje cells showed strong dendritic staining at E20. Unexpectedly, we also describe neurite staining in the septum, several hypothalamic nuclei, and a paramedian raphe area; the strongest neurite staining was in the median eminence. These novel localizations suggest new unexplored TRPC5 functions, and possible roles in late embryonic brain development.
Chemical and Biological Studies on Available Concentrated Protein in Local Market Using Experimental Animals

Whey protein is a mixture of proteins in whey, which is a byproduct of cheese production. It’s usually sold as a flavored powder, which is added to shakes, meal replacements and protein bars . Soybeans contain a stew of beneficial compounds such as amino acids, fiber, isoflavones and lecithins that may work synergistically to improve metrics like cholesterol numbers associated with heart health, keep in mind that highlyprocessed forms of soy aren’t likely to have the same impact. Beef is a complete protein, so it can provide all the amino acids that the body needs in just one source. Paleo beef protein powder is a more convenient way to get the protein the body needs. The beverages used in this study were Concentrated Protein such as) Whey protein, Soy Protein, Beef Protein) and Diet with Oat Using in this study Fourty Two(42)adult male albino rats, weigh(120±5g) were divied into 6 groups each of 7 rats. A group of them used as a control negative, and other groups were fed on these concentrated proteins for four weeks. The study of the impact role of these concentrated proteins on BWG,FER,FI ,Blood Components, CBC, Lipid Profile ,Liver Function and Kidney Function.
Role of the Yersinia pseudotuberculosis Virulence Plasmid in Pathogen-Phagocyte Interactions in Mesenteric Lymph Nodes

Yersinia pseudotuberculosis is an Enterobacteriaceae family member that is commonly transmitted by the fecal-oral route to cause infections. From the small intestine, Y. pseudotuberculosis can invade through Peyer’s patches and lymph vessels to infect the mesenteric lymph nodes (MLNs). ABSTRACT Yersinia pseudotuberculosis is an Enterobacteriaceae family member that is commonly transmitted by the fecal-oral route to cause infections. From the small intestine, Y. pseudotuberculosis can invade through Peyer’s patches and lymph vessels to infect the mesenteric lymph nodes (MLNs). Infection of MLNs by Y. pseudotuberculosis results in the clinical presentation of mesenteric lymphadenitis. MLNs are important for immune responses to intestinal pathogens and microbiota in addition to their clinical relevance to Y. pseudotuberculosis infections. A characteristic of Y. pseudotuberculosis infection in MLNs is the formation of pyogranulomas. Pyogranulomas are composed of neutrophils, inflammatory monocytes, and lymphocytes surrounding extracellular microcolonies of Y. pseudotuberculosis. Key elements of the complex pathogen-host interaction in MLNs have been identified using mouse infection models. Y. pseudotuberculosis requires the virulence plasmid pYV to induce the formation of pyogranulomas in MLNs. The YadA adhesin and the Ysc-Yop type III secretion system (T3SS) are encoded on pYV. YadA mediates bacterial binding to host receptors, which engages the T3SS to preferentially translocate seven Yop effectors into phagocytes. The effectors promote pathogenesis by blocking innate immune defenses such as superoxide production, degranulation, and inflammasome activation, resulting in survival and growth of Y. pseudotuberculosis. On the other hand, certain effectors can trigger immune defenses in phagocytes. For example, YopJ triggers activation of caspase-8 and an apoptotic cell death response in monocytes within pyogranulomas that limits dissemination of Y. pseudotuberculosis from MLNs to the bloodstream. YopE can be processed as an antigen by phagocytes in MLNs, resulting in T and B cell responses to Y. pseudotuberculosis. Immune responses to Y. pseudotuberculosis in MLNs can also be detrimental to the host in the form of chronic lymphadenopathy. This review focuses on interactions between Y. pseudotuberculosis and phagocytes mediated by pYV that concurrently promote pathogenesis and host defense in MLNs. We propose that MLN pyogranulomas are immunological arenas in which opposing pYV-driven forces determine the outcome of infection in favor of the pathogen or host.
Public opinion polarization on immigration in Italy: the role of traditional and digital news media practices

ABSTRACT Public opinion polarization on immigration can hinder social cohesion, integration policies and economic growth. Political campaigns and partisan news media systems have long been investigated in terms of potential drivers of mass polarization, often through a focus on one news media. Utilizing survey data collected by the Pew Research Center, the purpose of the present study is twofold: first, to provide insight into the state of polarization of the Italian public on immigrants-related issues during the campaign for 2018 General Elections, that is, in a context of increasing struggle on immigration between political elites and partisan news media; second, to analyze whether and how the frequency of use of traditional and digital news media and/or the political similarity of (online and offline) information networks have affected the probability of Italian citizens having polarized opinions on immigration. This study shows no significant divergences in the Italian public opinion toward extreme positions, but provide evidence of one-side extremism and alignment along two irreconcilable views. Furthermore, findings indicate deep differences in the effects of traditional and digital news media practices on individuals’ extreme and aligned positions on immigration. When various news media are considered, the effect of television is always the more robust.
An Overview of Deep Learning in MRI and CT Medical Image Processing

The medical image is a set of all organizations, institutions, and resources whose primary goal is to improve health. The extensive growth of medical data increases the utility of machine learning and deep learning in the healthcare domains. Nowadays, the use of in-depth training to process medical images has received particular attention. In recent years, medical instruments have developed rapidly with the help of artificial intelligence and are widely used to process medical images. Artificial intelligence is numerous sources of medical imaging processing such as X-ray, Computed Tomography (CT), and Magnetic Resonance Imaging (MRI). CT and MRI image processing tasks with a high computation time requirement and computation speed. Nowadays, one of the most critical trends in the development of computer technology in neuroscience is the processing of medical images and digital images, which are used to improve image quality, restore damaged images, identify individual elements and diagnose various diseases. In this paper, we briefly review the progress and challenges associated with in-deep learning in the processing of CT and MRI medical images.
Network Anomaly Detection Using Transfer Learning Based on Auto-Encoders Loss Normalization

Anomaly detection is a classic, long-term research problem. Previous attempts to solve it have used auto-encoders to learn a representation of the normal behaviour of networks and detect anomalies according to reconstruction loss. In this paper, we study the problem of anomaly detection in computer networks and propose the concept of "auto-encoder losses transfer learning". This approach normalizes auto-encoder losses in different model deployments, providing the ability to transform loss vectors of different networks with potentially significant varying characteristics, properties, and behaviors into a domain invariant representation. This is forwarded to a global detection model that can detect and classify threats in a generalized way that is agnostic to the specific network deployment, allowing for comprehensive network coverage.
Attribute Spaces: Supporting Design Space Exploration in Virtual Reality

Exploring the design space of configurations for objects in virtual scenes is a challenge within virtual reality authoring tools due to the lack of visualization capabilities, non-destructive operations, suggestions, and flexibility. This work introduces Attribute Spaces, tools for visualizing and manipulating object attributes in virtual reality during 3D content generation. Attribute Spaces enable designers to systematically explore design spaces by supporting rapid comparisons between design alternatives and offering design suggestions. Custom combinations of attributes can be grouped and manipulated simultaneously for several objects. The grouping supports the creation of custom operation combinations that can be used as tools to edit multiple attribute, as well as snapshots of promising design decisions for later review. In an evaluation of Attribute Spaces by 3D design experts, our approach was found to enhance users’ understanding of their design space exploration progress and showed promise for integration into existing 3D workflows.
Crisis Response Framework and Public Policy Response

Covid-19 brought an unprecedented and challenging time all over the globe. With the unpreparedness and lack of awareness regarding the global pandemic, it soon became an international concern. From loss of lives to loss of livelihood, the pandemic had a huge impact on global citizens and various nation-states. Unlike any other crisis, Covid-19 too pushed the government and its people to restructure and reform their framework, especially in the face of such an unprecedentedly adverse situation. This article highlights the need of a crisis response framework and formulation of agile public policy during such a global catastrophe. Taking the novel coronavirus as the epicentre demanding a rapid response formulation of Government of India, the article delineates upon strategic intervention of the government towards Covid-19 and the need of a crisis response framework for the future.
Wave- and drag-driven subharmonic responses of a floating wind turbine

Abstract The nonlinear hydrodynamic responses of a novel spar-type soft-moored floating offshore wind turbine are investigated via analysis of motion measurements from a wave-basin campaign. A prototype of the TetraSpar floater, supporting a $1:60$ scale model of the DTU 10 MW reference wind turbine, was subjected to irregular wave forcing (with no wind) and shown to exhibit subharmonic resonant motions, which greatly exceeded the wave-frequency motions. These slow-drift responses are excited nonlinearly, since the rigid-body natural frequencies of the system lie below the incident-wave frequency range. Pitch motion is examined in detail, allowing for identification of different hydrodynamic forcing mechanisms. The resonant response is found to contain odd-harmonic components, in addition to the even harmonics expected a priori and excited by second-order difference-frequency hydrodynamic interactions. Data analysis utilising harmonic separation and signal conditioning suggests that Morison drag excitation or third-order subharmonic potential flow forcing could be at play. In the extreme survival-conditions sea state, the odd resonant responses are identified to be drag-driven. Their importance for the tested floater is appreciable, as their magnitude is comparable to the second-order potential flow effects. Under such severe conditions, the turbine would not be operating, and as such neglecting aerodynamic forcing and motion damping is likely to be reasonable. Additionally, other possible drivers of the resonant pitch response are explored. Both Mathieu-type parametric excitation and wavemaker-driven second-order error waves are found to have negligible influence. However, we note slight contamination of the measurements arising from wave-basin sloshing.