Miracle-dz/UniFAR-FTUs huggingface dataset:
A dermocosmetic formulation containing Vichy volcanic mineralizing water, Vitreoscilla filiformis extract, niacinamide, hyaluronic acid, and vitamin E regenerates and repairs acutely stressed skin

The exposome has an impact on skin from life‐long exposure. Acute short‐term exposure to exposome stressors can also alter skin functions such as skin physical barrier and immune defenses, leading to skin dryness, sensitivity, flares of inflammatory skin conditions, or viral reactivations. Probiotics are defined as live microorganisms, which, when administered in adequate amounts, confer a health benefit on the host. An extract produced by lysing Vitreoscilla filiformis (VfeV) cultured in Vichy volcanic mineralizing water (VVMW) has properties of probiotic fractions. In this review, we present in vivo and ex vivo studies with a dermocosmetic formulation containing 80% VVMW, 5% VfeV, 4% niacinamide (vitamin B3), 0.4% hyaluronic acid, and 0.2% vitamin E (M89PF) to evaluate the clinical efficacy in preventing and repairing stressed skin. Skin barrier benefits of M89PF were shown in studies after the skin was exposed to sudden thermal changes, after skin irritation by tape stripping, and in sleep‐deprived women. M89PF significantly accelerated skin renewal compared to untreated skin. Skin antioxidant defense activity of M89PF was shown after exposure to stress from UVA plus cigarette smoke aggression. Skin microbiome recovery after acute stress from a harsh cleanser was significantly better in M89PF‐treated skin compared to bare skin. Clinical benefits of M89PF on correcting clinical signs of stressed skin were shown in both Caucasian and Asian women exposed to a stressful lifestyle and various external (pollution, tobacco smoking, solar radiation) and internal (poor sleep, stressful work, unbalanced diet, and alcohol consumption) exposome factors. M89PF also showed depigmenting properties on dark spots in Asian women. Further clinical studies are now warranted to evaluate the efficacy of M89PF as adjuvant care to prevent and repair skin barrier disruption and reinforce skin defenses in skin exposed to acute stresses.
Uncovering the Truth about Fake News: A Research Model Grounded in Multi-Disciplinary Literature

ABSTRACT Many diverse fields across academia are interested in the fake news (FN) phenomenon. A multidisciplinary literature review can provide researchers with new insights, alternative methods, and theories from other fields. The present review incorporates FN research across fields and organizes it into three categories: FN Stimuli, the triggers and impetus for people and organizations to engage with FN; FN Actions, which encompass the activities and processes undertaken in FN; and FN Outcomes, the effects and consequences of FN Actions. Within these categories, we systematize research topics into major themes. Stimuli: motivation; Actions: fabrication, propagation, mitigation; and Outcomes: persuasion, conviction, polarization, and aversion. We identify relationships that are important in understanding the impact on society: the cycle of amplification, the cycle of fragmentation, and the progression from social polarization and aversion into motivation for more fake news. Last, we distinguish FN roles, including creators, consumers, influencers, endorsers, propagators, and resistors.
Dynamic Effects of Falsehoods and Corrections on Social Media: A Theoretical Modeling and Empirical Evidence

ABSTRACT Government agencies and fact-checking websites have been combating the spread of falsehoods on social media by issuing correction messages. There has been, however, no research on the effectiveness of correction messages on falsehoods and their dynamic interaction. We develop a theoretical model of the competition between falsehoods and correction messages on Twitter and show different interventions under which falsehoods could be hampered. Moreover, we use panel vector autoregressive models and machine learning techniques to empirically investigate the dynamic interactions between falsehoods and correction messages through a unique longitudinal dataset of 279,597 tweets. We find that correction messages cause an increase in the propagation of falsehoods on social media if their use is not optimized. This study highlights the importance of having government agencies, fact-checking websites, and social media platforms work together to optimize effective correction messages. We argue such an effort will counter the spread of falsehoods.
Emotions: The Unexplored Fuel of Fake News on Social Media

ABSTRACT Easy access to equipment, software, and platforms to create, distribute, and provide access to fake news stories has exacerbated the problem of fake news, making for a large number of highly biased sources that are reaching the mainstream through social networks. The economics of emotion theory proposes that fake news headlines are created to evoke emotional responses in readers that will cause them to interact with the article in a way that allows the creator to make a profit (through clicking on the link to the full article, by sharing the article, etc.). This mixed methods study investigates the process by which individuals experience discrete emotional reactions to fake news headlines, and how these emotions contribute to the perpetuation of fake news through sharing behaviors. U.S. participants (n=879 across two waves) viewed one of eight false news headlines and reported their emotional reactions, belief in the headline, and potential sharing behaviors. In general, participants were more likely to believe headlines that aligned with their existing beliefs (e.g., liberals were more likely to believe negative news about conservatives), reacted with more negative emotions to headlines that attacked their party, and were more likely to report intentions to suppress (e.g., post a link to a fact check) fake news that attacked their own party. Emotional reactivity of participants was associated with response behavior intentions such that participants who reported high levels of emotions were more likely to take actions that would spread or suppress the fake news, participants who reported low levels of emotions were more likely to ignore or disengage from the spread of false news, and participants who reported high levels of negative emotions and low levels of positive emotions were more likely to suppress the spread of fake news and less likely to contribute to the spread of fake news. Our findings are synthesized into a process model that explains how discrete emotions and beliefs influence sharing behaviors. Implications for mitigating the spread of fake news are discussed in terms of this model.
Correlation between serum factor VIII:C levels and deep vein thrombosis following gynecological surgery

ABSTRACT Deep vein thrombosis (DVT) is common in patients following gynecological surgery. Coagulation factor VIII (FVIII) is an important part of the human coagulation system, and FVIII:C is a component of FVIII with anticoagulant activity. 800 patients who underwent gynecological surgery were enrolled. General clinical data were harvested, and pre – and postoperative serum FVIII levels were determined. Lower-extremity ultrasound examination and/or postoperative pulmonary angiography were performed. Related data were analyzed statistically. DVT was the first manifestation of venous thromboembolism in all cases. There were a total of 46 cases, and the incidence of DVT was 5.8%. Progression to pulmonary embolism was confirmed in 16 cases, with an incidence of 2.0%. The independent risk factors for DVT after gynecological surgery were postoperative FVIII:C levels (odds ratio [OR] = 1.01), age (OR = 6.57), and operation time ≥3 hours (OR = 2.90) (P < 0.05). When the FVIII:C level was greater than the 75th centile (≥150 IU/dL), the risk of DVT was 2.99 times higher than that below the 25th centile (<100 IU/dL) (P < 0.05). When combined with the risk factor of operation time ≥3 hours, the risk increased to 3.17 times (P = 0.10). When combined with age ≥60 years, the risk was significantly increased, reaching 12.0 times (P < 0.05). Serum FVIII:C levels are an independent risk factor for DVT after gynecological surgery. Higher levels increase the risk of DVT after gynecological surgery, and they may have a dose-dependent relationship. A synergistic effect exists in combination with other risk factors, which further increases the risk.
A holistic review on advanced bi-directional EV charging control algorithms

The rapid growth of electric vehicles (EVs) has promised a next-generation transportation system with reduced carbon emission. The fast development of EVs and charging facilities is driving the evolution of Internet of Vehicles (IoV) to Internet of Electric Vehicles (IoEV). IoEV benefits from both smart grid and Internet of Things (IoT) technologies which provide advanced bi-directional charging services and real-time data processing capability, respectively. The major design challenges of the IoEV charging control lie in the randomness of charging events and the mobility of EVs. In this article, we present a holistic review on advanced bi-directional EV charging control algorithms. For Grid-to-Vehicle (G2V), we introduce the charging control problem in two scenarios: 1) Operation of a single charging station and 2) Operation of multiple charging stations in coupled transportation and power networks. For Vehicle-to-Grid (V2G), we discuss how EVs can perform energy trading in the electricity market and provide ancillary services to the power grid. Besides, a case study is provided to illustrate the economic benefit of the joint optimization of routing and charging scheduling of multiple EVs in the IoEV. Last but not the least, we will highlight some open problems and future research directions of charging scheduling problems for IoEVs.
Small Fiber Polyneuropathy May Be a Nexus Between Autonomic Nervous System Dysregulation and Pain in Interstitial Cystitis/Bladder Pain Syndrome

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a highly heterogeneous chronic and debilitating condition which effects millions of women and men in the United States. While primarily defined by urinary symptoms and pain perceived to be emanating from the bladder, IC/BPS patients frequently have co-occurring conditions and symptoms, many of which affect diverse body systems related to autonomic nervous system function. The impact on the autonomic system appears to stem from increased sympathetic innervation of the urinary tract, along with increased systemic sympathetic tone and decreased parasympathetic tone. Concurrent with these findings is evidence for destruction of peripheral sympathetic innervation to the sweat glands which may relate to small fiber polyneuropathy. It is unknown to what degree the wider alterations in autonomic function are also related to destruction/alterations in the small fibers carrying autonomic innervation. This potential nexus is an important point of investigation to better understand the unclarified pathophysiology of interstitial cystitis/bladder pain syndrome, the numerous co-occurring symptoms and syndromes, and for the identification of novel targeted therapeutic strategies.
Reconstruction With 3D-Printed Prostheses After Sacroiliac Joint Tumor Resection: A Retrospective Case-Control Study

Background Sacroiliac joint tumor is rare, and the reconstruction after tumor resection is difficult. We aimed to analyze and compare the clinical effects of three-dimensional (3D) printed prostheses and bone cement combined with screws for bone defect reconstruction after sacroiliac joint tumor resection. Methods Twelve patients with sacroiliac joint tumors who underwent tumor resection and received 3D-printed prostheses to reconstruct bone defects in our hospital from January 2014 to December 2020 were included in the study group Twelve matched patients who underwent sacroiliac joint tumor resection and reconstruction with bone cement and screws in the same time period were selected as the control group. Results In the 3D-printing group, six cases were extensively excised, and six cases were marginally excised. All patients were followed up for 6–90 months, and the median follow-up time was 21 months. Among them, nine patients had disease-free survival, two survived with tumor recurrence, and one died due to tumor metastasis. The MSTS-93 score of the surviving patients was 24.1 ± 2.8. The operation time was 120.30 ± 14.50 min, and the intraoperative bleeding was 625.50 ± 30.00 ml. In the control group, seven cases were extensively excised, and five cases were marginally excised. All patients were followed up for 6–90 months, with a median follow-up time of 20 months. Among them, nine patients had disease-free survival, one survived with tumor recurrence, and two died due to tumor metastasis. The MSTS-93 score of the patients was 18.9 ± 2.6. The operation time was 165.25 ± 15.00 min, and the intraoperative bleeding was 635.45 ± 32.00 ml. There was no significant difference in survival status, intraoperative blood loss, or complications between the two groups (P>0.05). However, there were statistically significant differences in operative time and postoperative MSTS-93 scores between the two groups (P<0.05). Conclusions After resection of the sacroiliac joint tumor, reconstruction using 3D printed prostheses was shorter and resulted in better movement function.
A Compact Printed Multi-band Antenna for Laptop Applications

This study proposes a compact printed multi-band antenna, which has the advan- tages of simple structure, small size, easy fabrication, and making integration within thin laptop. The main operating frequencies of the proposed antenna are at GPS (1.575GHz), WLAN (2.4, 5.8GHz), Bluetooth (2.45GHz) and WiMAX (2.5, 3.5, 5.5GHz) bands. The main structure of the antenna is composed of T-shaped monopole and grounded inverted L-shaped branch. The T-shape monopole excites 2.4GHz operating frequency band. And, the grounded inverted L- shaped branch not only can excite 3.5GHz operating band but also can be used for impedance matching, which can tune the bandwidth of each operating band. A branch is added on the left part of T-shaped monopole which can excite GPS band (1.575GHz). Finally, the 5.5GHz operational frequency of WiMAX can be excited by adding a stub on the T-shaped monopole branch. Therefore, a multi-band antenna for laptop applications is achieved. The antenna occupies a small area of 9 £ 47mm 2 only. This antenna is fed on the T-shaped monopole by a 50-› coaxial cable. The measured result shows that the 10dB return loss is satisfled at each operating band, and has a good agreement with simulated result. Moreover, the gain, radiation e-ciency and radiation pattern of each operating center frequency were also simulated and measured. They demonstrate very good performances. The gain is about 1:25 » 6:38dBi and radiation e-ciency ranges from 67% to 95% at each band. The measured radiation pattern is similar to general monopole antenna. The characteristics of the antenna make it attractive for practical application in laptops.
Gene Co-Expression Network Analysis Identifies Vitamin D-Associated Gene Modules in Adult Normal Rectal Epithelium Following Supplementation

Colorectal cancer (CRC) is a common, multifactorial disease. While observational studies have identified an association between lower vitamin D and higher CRC risk, supplementation trials have been inconclusive and the mechanisms by which vitamin D may modulate CRC risk are not well understood. We sought to perform a weighted gene co-expression network analysis (WGCNA) to identify modules present after vitamin D supplementation (when plasma vitamin D level was sufficient) which were absent before supplementation, and then to identify influential genes in those modules. The transcriptome from normal rectal mucosa biopsies of 49 individuals free from CRC were assessed before and after 12 weeks of 3200IU/day vitamin D (Fultium-D3) supplementation using paired-end total RNAseq. While the effects on expression patterns following vitamin D supplementation were subtle, WGCNA identified highly correlated genes forming gene modules. Four of the 17 modules identified in the post-vitamin D network were not preserved in the pre-vitamin D network, shedding new light on the biochemical impact of supplementation. These modules were enriched for GO terms related to the immune system, hormone metabolism, cell growth and RNA metabolism. Across the four treatment-associated modules, 51 hub genes were identified, with enrichment of 40 different transcription factor motifs in promoter regions of those genes, including VDR:RXR. Six of the hub genes were nominally differentially expressed in studies of vitamin D effects on adult normal mucosa organoids: LCN2, HLA-C, AIF1L, PTPRU, PDE4B and IFI6. By taking a gene-correlation network approach, we have described vitamin D induced changes to gene modules in normal human rectal epithelium in vivo, the target tissue from which CRC develops.
Specific Human ATR and ATM Inhibitors Modulate Single Strand DNA Formation in Leishmania major Exposed to Oxidative Agent

Leishmania parasites are the causative agents of a group of neglected tropical diseases known as leishmaniasis. The molecular mechanisms employed by these parasites to adapt to the adverse conditions found in their hosts are not yet completely understood. DNA repair pathways can be used by Leishmania to enable survival in the interior of macrophages, where the parasite is constantly exposed to oxygen reactive species. In higher eukaryotes, DNA repair pathways are coordinated by the central protein kinases ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3 related (ATR). The enzyme Exonuclease-1 (EXO1) plays important roles in DNA replication, repair, and recombination, and it can be regulated by ATM- and ATR-mediated signaling pathways. In this study, the DNA damage response pathways in promastigote forms of L. major were investigated using bioinformatics tools, exposure of lineages to oxidizing agents and radiation damage, treatment of cells with ATM and ATR inhibitors, and flow cytometry analysis. We demonstrated high structural and important residue conservation for the catalytic activity of the putative LmjEXO1. The overexpression of putative LmjEXO1 made L. major cells more susceptible to genotoxic damage, most likely due to the nuclease activity of this enzyme and the occurrence of hyper-resection of DNA strands. These cells could be rescued by the addition of caffeine or a selective ATM inhibitor. In contrast, ATR-specific inhibition made the control cells more susceptible to oxidative damage in an LmjEXO1 overexpression-like manner. We demonstrated that ATR-specific inhibition results in the formation of extended single-stranded DNA, most likely due to EXO1 nucleasic activity. Antagonistically, ATM inhibition prevented single-strand DNA formation, which could explain the survival phenotype of lineages overexpressing LmjEXO1. These results suggest that an ATM homolog in Leishmania could act to promote end resection by putative LmjEXO1, and an ATR homologue could prevent hyper-resection, ensuring adequate repair of the parasite DNA.
Does the Correspondence Bias Apply to Social Robots?: Dispositional and Situational Attributions of Human Versus Robot Behavior

Increasingly, people interact with embodied machine communicators and are challenged to understand their natures and behaviors. The Fundamental Attribution Error (FAE, sometimes referred to as the correspondence bias) is the tendency for individuals to over-emphasize personality-based or dispositional explanations for other people’s behavior while under-emphasizing situational explanations. This effect has been thoroughly examined with humans, but do people make the same causal inferences when interpreting the actions of a robot? As compared to people, social robots are less autonomous and agentic because their behavior is wholly determined by humans in the loop, programming, and design choices. Nonetheless, people do assign robots agency, intentionality, personality, and blame. Results of an experiment showed that participants made correspondent inferences when evaluating both human and robot speakers, attributing their behavior to underlying attitudes even when it was clearly coerced. However, they committed a stronger correspondence bias in the case of the robot–an effect driven by the greater dispositional culpability assigned to robots committing unpopular behavior–and they were more confident in their attitudinal judgments of robots than humans. Results demonstrated some differences in the global impressions of humans and robots based on behavior valence and choice. Judges formed more generous impressions of the robot agent when its unpopular behavior was coerced versus chosen; a tendency not displayed when forming impressions of the human agent. Implications of attributing robot behavior to disposition, or conflating robot actors with their actions, are addressed.
Semi-MsST-GAN: A Semi-Supervised Segmentation Method for Corneal Ulcer Segmentation in Slit-Lamp Images

Corneal ulcer is a common leading cause of corneal blindness. It is difficult to accurately segment corneal ulcers due to the following problems: large differences in the pathological shapes between point-flaky and flaky corneal ulcers, blurred boundary, noise interference, and the lack of sufficient slit-lamp images with ground truth. To address these problems, in this paper, we proposed a novel semi-supervised multi-scale self-transformer generative adversarial network (Semi-MsST-GAN) that can leverage unlabeled images to improve the performance of corneal ulcer segmentation in fluorescein staining of slit-lamp images. Firstly, to improve the performance of segmenting the corneal ulcer regions with complex pathological features, we proposed a novel multi-scale self-transformer network (MsSTNet) as the MsST-GAN generator, which can guide the model to aggregate the low-level weak semantic features with the high-level strong semantic information and adaptively learn the spatial correlation in feature maps. Then, to further improve the segmentation performance by leveraging unlabeled data, the semi-supervised approach based on the proposed MsST-GAN was explored to solve the problem of the lack of slit-lamp images with corresponding ground truth. The proposed Semi-MsST-GAN was comprehensively evaluated on the public SUSTech-SYSU dataset, which contains 354 labeled and 358 unlabeled fluorescein staining slit-lamp images. The results showed that, compared with other state-of-the-art methods, our proposed method achieves better performance with comparable efficiency.