Miracle-dz/UniFAR-FTUs huggingface dataset:
Canonical and Non-Canonical Roles of PFKFB3 in Brain Tumors

PFKFB3 is a bifunctional enzyme that modulates and maintains the intracellular concentrations of fructose-2,6-bisphosphate (F2,6-P2), essentially controlling the rate of glycolysis. PFKFB3 is a known activator of glycolytic rewiring in neoplastic cells, including central nervous system (CNS) neoplastic cells. The pathologic regulation of PFKFB3 is invoked via various microenvironmental stimuli and oncogenic signals. Hypoxia is a primary inducer of PFKFB3 transcription via HIF-1alpha. In addition, translational modifications of PFKFB3 are driven by various intracellular signaling pathways that allow PFKFB3 to respond to varying stimuli. PFKFB3 synthesizes F2,6P2 through the phosphorylation of F6P with a donated PO4 group from ATP and has the highest kinase activity of all PFKFB isoenzymes. The intracellular concentration of F2,6P2 in cancers is maintained primarily by PFKFB3 allowing cancer cells to evade glycolytic suppression. PFKFB3 is a primary enzyme responsible for glycolytic tumor metabolic reprogramming. PFKFB3 protein levels are significantly higher in high-grade glioma than in non-pathologic brain tissue or lower grade gliomas, but without relative upregulation of transcript levels. High PFKFB3 expression is linked to poor survival in brain tumors. Solitary or concomitant PFKFB3 inhibition has additionally shown great potential in restoring chemosensitivity and radiosensitivity in treatment-resistant brain tumors. An improved understanding of canonical and non-canonical functions of PFKFB3 could allow for the development of effective combinatorial targeted therapies for brain tumors.
A Fast Convergence ALOHA Based on Reinforcement Learning

—To improve the throughput of ALOHA in Ad Hoc, we proposed a fast convergence framed ALOHA (F-ALOHA). F-ALOHA combines ALOHA with reinforcement learning to achieve an optimal way to select time slot. Q-l earning is applied to update the Q-value of the slot by feedback and memory. The agents remember the number of consecutive conflicts or successes in the current slot and the idle slots in the last frame. The truncated binary exponential increase algorithm is adopted to update Q-value to accelerate convergence. The simulation results show that the average convergence time of this algorithm is significantly lower than other ALOHA algorithms, and the throughput is higher than others.
Stimulating Critical Thinking Skills Through Critical Thinking Question List (CTQL)

Critical thinking is an essential skill needed by a physician. One of the ways to learn these skills is using a critical thinking question list (CTQL). This study was aimed to evaluate the effect of CTQL in stimulating students' critical thinking skill in the tutorial Problem-Based Learning (PBL). This study was a cross-sectional study using a mixedmethod approach. The subjects were first-year students who took the first course (n=177). Quantitative data was collected through the score of critical thinking (CT) examination and tutorial performance, while the qualitative data was collected using an open questionnaire. CT score consisted of students' work in applying CTQL based on a reading text. It includes two parts (creating questions and answering them based on a reading text). Students had applied the CTQL method during the first course. Quantitative data was then analysed using Spearman correlation, and the qualitative data was analysed thematically. Tutorial performance correlated significantly with the total CT score (p< 0.01), and it also had a significant correlation with the CT score part2 (p<0.01). However, CT part 1 did not have a significant correlation with the students' tutorial performance. The qualitative data indicated that CTQL supported students' critical thinking activities during the tutorial, such as: criticising others' opinion, selecting appropriate learning resources, asking more various questions, explaining using their own word, and thinking comprehensively. A critical thinking questions list could be an alternative method to teach critical thinking skills. It could be conducted by stimulating students to create questions and then answer them.
Incidence of hyperglycemia in patients with corticosteroid therapy

Introduction: Corticosteroid-induced hyperglycemia is a well-known adverse effect of glucocorticoid (GC) treatment. It can occur in both diabetic and non-diabetic patients. Autor correspondiente: Dr. Freddy Javier Bruno Dirección: Itauguá, Paraguay Teléfono: +595. 961888364 Correo electrónico: freddyws@hotmail.com Artículo recibido: 15 enero 2018 Artículo aceptado: 04 agosto 2018 38 Rev. virtual Soc. Parag. Med. Int. setiembre 2018; 5 (2):38-44 Doi:10.18004/rvspmi/2312-3893/2018.05(02)38-044 Incidencia de hiperglicemia en pacientes con corticoterapia Objectives: To determine the incidence of corticosteroid-induced hyperglycemia, as well as the indications and types of corticosteroids used in patients with hyperglycemia induced by these drugs in patients who attend the outpatient clinical services of the Hospital Nacional de Itauguá. Material and methods: Observational, descriptive, longitudinal, prospective study carried out in men and women, older than 18 years old, who received enteral or parenteral corticotherapy and attended the outpatient clinical services of the Hospital Nacional in 2017. Results: The mean age of the patients studied was 51±16 years and female patients predominated (56.7%). While 35% of patients presented hyperglycemia, 26% had HbA1C levels ≥6.5%. Only 14% were known diabetics. The autoimmune pathologies that most frequently required corticotherapy were systemic lupus erythematosus and rheumatoid arthritis. Prednisone was the glucocorticoid used most frequently. No patient presented acute decompensation such as ketoacidosis or hyperosmolar state. Conclusion: The incidence of hyperglycemia induced by corticosteroid therapy was 35% in diabetic and non-diabetic patients. The most frequent indication for the use of corticosteroids was autoimmune diseases and the most frequently used corticosteroid was prednisone.
GRASP-125: A Dataset for Greek Vascular Plant Recognition in Natural Environment

Plant identification from images has become a rapidly developing research field in computer vision and is particularly challenging due to the morphological complexity of plants. The availability of large databases of plant images, and the research advancements in image processing, pattern recognition and machine learning, have resulted in a number of remarkably accurate and reliable image-based plant identification techniques, overcoming the time and expertise required for conventional plant identification, which is feasible only for expert botanists. In this paper, we introduce the GReek vAScular Plants (GRASP) dataset, a set of images composed of 125 classes of different species, for the automatic identification of vascular plants of Greece. In this context, we describe the methodology of data acquisition and dataset organization, along with the statistical features of the dataset. Furthermore, we present results of the application of popular deep learning architectures to the classification of the images in the dataset. Using transfer learning, we report 91% top-1 and 98% top-5 accuracy.
PCR-based detection of prey DNA in the gut contents of the tiger-fly, Coenosia attenuata (Diptera: Muscidae), a biological control agent in Mediterranean greenhouses

The tiger-fl y Coenosia attenuata Stein (Diptera: Muscidae: Coenosiini) is a generalist predator that preys on several pests of greenhouse crops and is considered a biological control agent in the Mediterranean region. Previous behavioural observations identifi ed its preferred prey, but a more in-depth evaluation will benefi t from using Polymerase Chain Reaction amplifi cation of prey DNA remains in the gut of this predator. To evaluate the rate of decay and suitability of this method for use in the fi eld assessments, we carried out a laboratory feeding calibration experiment on 355 females of C. attenuata, which were killed at different intervals of time after ingestion (10 time points from 0 to 48 h). The prey species tested were: Trialeurodes vaporariorum (Westwood) (Hemiptera: Aleyrodidae: Trialeurodini), Liriomyza huidobrensis (Blanchard) (Diptera: Agromyzidae), Diglyphus isaea (Walker) (Hymenoptera: Eulophidae: Cirrospilini), Bradysia impatiens (Johannsen) (Diptera: Sciaridae) and Drosophila mercatorum Patterson & Wheeler (Diptera: Drosophilidae: Drosophilini). Based on a probit model, amplifi cation success of prey DNA declined exponentially with increasing time after ingestion. The half-time molecular detection differed between species, ranging from an average of 5 h for T. vaporariorum and D. isaea, 6 h for B. impatiens, 15 h for L. huidobrensis to more than 40 h for D. mercatorum. This study confi rmed the feasibility of using DNA based detection to identify prey species in the gut contents of C. attenuata and provided calibration curves for a better understanding of predation activity in this agroecosystem. * Present addresses: S.G. Seabra – Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira no 100, 1349-008 Lisboa, Portugal; J. Martins – Ascenza Agro, Lda. , Alameda dos Oceanos 1.06. 1.1, 1990-207 Lisboa, Portugal; I. Freitas – CIBIO/InBIO, Research Center in Biodiversity and Genetic Resources of the University of Porto, Vairão, Portugal INTRODUCTION Generalist invertebrate predators may be important biological control agents against crop pests, as shown in a number of manipulative fi eld experiments (Symondson et al., 20 02). When considering introducing or enhancing a particular generalist predator species for pest control, its prey preference and effect on pests (target) and non-pests (non-target) should be studied (Stilin & Simberloff, 2000; Louda et al., 2003), even when native control agents are considered (Howarth, 2000). Field observations of predator preferences are not always feasible and molecular anaEur. J. Entomol. 118: 335–343, 2021 doi: 10.14411/eje.2021. 035
Paralytic Shellfish Poisoning (PSP) in Mussels from the Eastern Cantabrian Sea: Toxicity, Toxin Profile, and Co-Occurrence with Cyclic Imines

In the late autumn of 2018 and 2019, some samples taken by the official monitoring systems of Cantabria and the Basque Country were found to be paralytic shellfish poisoning (PSP)-positive using a mouse bioassay. To confirm the presence of PSP toxins and to obtain their profile, these samples were analyzed using an optimized version of the Official Method AOAC 2005.06 and using LC–MS/MS (HILIC). The presence of some PSP toxins (PSTs) in that geographical area (~600 km of coast) was confirmed for the first time. The estimated toxicities ranged from 170 to 983 µg STXdiHCl eq.·kg−1 for the AOAC 2005.06 method and from 150 to 1094 µg STXdiHCl eq.·kg−1 for the LC–MS/MS method, with a good correlation between both methods (r2 = 0.94). Most samples contained STX, GTX2,3, and GTX1,4, and some also had NEO and dcGTX2. All of the PSP-positive samples also contained gymnodimine A, with the concentrations of the two groups of toxins being significantly correlated. The PSP toxin profiles suggest that a species of the genus Alexandrium was likely the causative agent. The presence of gymnodimine A suggests that A. ostenfeldii could be involved, but the contribution of a mixture of Alexandrium species cannot be ruled out.
Bicomponent colorimetric probe based on carbon quantum dots and o-phenylenediamine for sensitive and selective Cu2+ sensing

A bicomponent colorimetric probe based on carbon quantum dots (CQDs) and o-phenylenediamine (OPD) was established for the detection of Cu2+. Theoretically, light-generated electrons from CQDs were trapped by the dissolved oxygen, resulting in the production of superoxide radicals. The colorless OPD was oxidized by the superoxide radicals to its yellow oxidation product (OPDox). On the other hand, Cu2+ can bind onto the surface of CQDs and change the band gap of the CQDs. This change induces an inhibition of the photo-oxidation of OPD, thus resulting in a decrease of the absorbance of OPDox. The mechanism was demonstrated by a series of control experiments. The parameters influencing the sensing performance as well as potential interferences were investigated. Under the optimum conditions, a limit of detection of 30 nM was achieved. Moreover, this sensing system was applied to analyze Cu2+ in seawater and tapwater samples, and achieved satisfying results.
The Effect of Magnolia Bark on the Metabolic Inflammation and Insulin Resistance of ob/ob Mice

Objective: This study was undertaken to investigate how magnolia bark extract affects ob/ob mouse in terms of metabolic inflammation and insulin resistance. Methods: Leptin-deficient ob/ob mice were divided into 2 groups (n=5): a normal saline treatment (=control) and magnolia bark treatment. Wild type mice were the lean group (n=5). After 5 weeks, we measured fasting blood sugar (FBS) and conducted oral glucose tolerance tests (OGTTs) in each group. After 6 weeks, we measured body weight, epididymal fat pad weight, liver weight, serum glucose, serum insulin, and gene expression of tumor necrosis factor-α, interferon-γ, and interleukin-6. We characterized the phenotype of adipose tissue macrophages (ATMs) and analyzed fractions of the phenotype in each group by flow cytometry. Results: In the magnolia bark group, fasting blood sugar, oral glucose tolerance levels, and insulin resistance (HOMA-IR) were significantly decreased. The population and proportion of ATMs among leukocytes in adipose tissue were significantly decreased in the magnolia bark group. The population and proportion of M1 type ATMs among ATMs were significantly decreased in the magnolia bark group. Gene expression of tumor necrosis factor-α was significantly decreased in the magnolia bark group. Conclusions: These results support a positive effect of magnolia bark on metabolic diseases such as insulin resistance and metabolic inflammation in leptin-deficient ob/ob mice.
Does paternal involvement matter for early childhood development in rural China?

Abstract Research in developed countries has found that paternal involvement has positive and significant effects on early childhood development (ECD). Less is known, however, about the state of paternal involvement and its influence on ECD in rural China. Using data collected in Southern China that included 1,460 children aged 6–42 months and their fathers (as well as their primary caregivers), this study examines the association between paternal involvement and ECD. Although the results demonstrate that the average level of paternal involvement is low in rural China, paternal involvement is related to a significant increase in three domains of ECD (cognition, language, and social-emotional skills). Older children benefit significantly more than do younger children from paternal involvement in all domains of ECD. The results also show that, if the mother is the primary caregiver, the mother’s higher educational level and the family’s higher socioeconomic status are positively associated with paternal involvement.
Eight cycles of half-sib family recurrent selection to improve rubber yield in Russian dandelion

Abstract: Russian dandelion (Taraxacum kok-saghyz) produces natural rubber which can complement the world’s supply of this strategic commodity, derived mainly from the Para rubber tree (Hevea brasiliensis). Four cycles of half-sib family recurrent selection conducted previously in Russian dandelion improved rubber yield nearly 50%. The objectives of this research were to continue selection for four additional cycles and evaluate progress from eight generations of breeding, and assess the potential for future gains. Rubber yield increased from 0.205 to 0.378 g/plant from Cycle 0 (C0) to C8, representing an 84% improvement, or 10% per cycle. Increases from C0 to C4 were similar to those from C4 to C8. Root dry weight did not increase from selection and improved yield only resulted from enhancing rubber percentage which changed from 4.35% to 7.62%. Selection response has not plateaued, and phenotypic variation has not decreased, indicating continued gains can occur with additional breeding.
DAMPAK SHARING KNOWLEDGE TERHADAP BEST OPERATIONAL PRACTICE MELALUI ORGANIZATIONAL CITIZENSHIP BEHAVIOR DAN SERVICE QUALITY DI POLWILTABES SURABAYA

Sharing Knowledge is originated from the interaction between individuals which will form a group or working group in a company, while the working group with expertise/skills is called teamwork. The working group should be developed to be able to communicate and have good relationships within the department, between departments and between organizations. Good communication within the organization will improve the working relationship to be more intense and faster. There are no boundaries either between individuals or individuals and departments in the organization so as to create an effective working relationship and a strong team work which lead to the creation of the best practices operational. Based on the survey by interviewing and spreading questionnaires to 266 police members of the police in POLWILTABES SURABAYA about sharing knowledge of best operational practices (BOP) in the police organization through team work's affectivity and OCB (organizational citizenship behavior). The results showed that sharing knowledge does not directly impact organizational citizenship behavior as an organizational culture, but it is indirectly give impact through the team work's affectivity moderator variable. Sharing knowledge as an organizational culture has an impact on enhancing the effectiveness of team work. The Effectiveness of team work influence organizational citizenship behavior in police organizations to increase the best operational practice. Team work's affectivity has influence towards Best Operational Practices (BOP) in the police organization. OCB (Organizational citizenship behavior) also has influence towards the best operational practices (BOP) in the police organization.
Choices on sampling, sequencing, and analyzing DNA influence the estimation of community composition of plant fungal symbionts

Abstract Plant root symbionts, namely mycorrhizal fungi, can be characterized using a variety of methods, but most of these rely on DNA. While Sanger sequencing still fulfills particular research objectives, next‐generation sequencing currently dominates the field, thus understanding how the two methods differ is important for identifying both opportunities and limitations to characterizing fungal communities. In addition to testing sequencing methods, we also examined how roots and soils may yield different fungal communities and how disturbance may affect those differences. We sequenced DNA from ectomycorrhizal fungi colonizing roots of Pinus banksiana and found that operational taxonomic unit richness was higher, and compositional variance lower, for Illumina MiSeq–sequenced communities compared to Sanger‐sequenced communities. We also found that fungal communities associated with roots were distinct in composition compared to those associated with soils and, moreover, that soil‐associated fungi were more clustered in composition than those of roots. Finally, we found community dissimilarity between roots and soils was insensitive to disturbance; however, rarefying read counts had a sizeable influence on trends in fungal richness. Although interest in mycorrhizal communities is typically focused on the abiotic and biotic filters sorting fungal species, our study shows that the choice of methods to sample, sequence, and analyze DNA can also influence the estimation of community composition.
La “municipalización social” de “lo nuestro” existente en los circuitos paralelos de puesta en valor del patrimonio cultural local, Almadén (Ciudad Real).

El artículo que presento a continuación intenta ser un pequeño acercamiento a un estudio mucho más amplio y complejo, centrado en el análisis del cambio cultural que está sufriendo un municipio a raíz de la desaparición de la estructura económica que lo sustentaba, y que daba sentido a su identidad. Esta casuística no se produjo por el agotamiento de un recurso natural sino curiosamente, y en palabras de Philippe Descola, por una modificación de la “construcción social de la naturaleza” por motivos políticos y económicos, lo que ha dificultado aún más la implicación de toda la población en dicha dinámica. Aun así, los agentes necesitan luchar por su supervivencia, de ahí que se generen actuaciones paralelas al “circuito oficial” como una forma de reivindicación de su papel crítico en el proceso.
2017 ESC GUIDELINES ON THE DIAGNOSIS AND TREATMENT OF PERIPHERAL ARTERIAL DISEASES, IN COLLABORATION WITH THE EUROPEAN SOCIETY FOR VASCULAR SURGERY (ESVS)

Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries.Endorsed by: the European Stroke Organization (ESO) The Task Force for the Diagnosis and Treatment of Peripheral Arterial Diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery (ESVS)