Miracle-dz/UniFAR-FTUs huggingface dataset:
Survival Predictors of Head and Neck Burkitt’s Lymphoma: An Analysis of the SEER Database

Objective To analyze population-level data for Burkitt’s lymphoma of the head and neck. Study Design Retrospective study of a national cancer database. Setting Academic medical center. Methods The SEER database (Surveillance, Epidemiology, and End Results) identified all patients with primary Burkitt’s lymphoma of the head and neck from 1975 to 2015. Demographic, clinicopathologic, and treatment characteristics were analyzed. Multivariable Cox regressions analyzed factors associated with survival while controlling for baseline differences. Results A total of 920 patients with a mean (SD) age of 37.6 years (25.0) were identified. A majority of patients were White (82.8%) and male (72.3%). The most primary common sites included the lymph nodes (61.3%), pharynx (17.7%), and nasal cavity/paranasal sinuses (5.2%). The majority of patients received chemotherapy (90.5%), while fewer underwent surgery (42.1%) or radiotherapy (12.8%). Choice of treatment differed significantly among patients of different ages, year of diagnosis, primary site, nodal status, and Ann Arbor stage. Overall 10-year survival was 67.8%. On multivariable Cox regression, patients with older age (hazard ratio [HR], 1.05 per year; P < .001) and higher stage at presentation had increased risk of mortality (P < .001). Furthermore, cases diagnosed between 2006 and 2015 (HR, 0.35; P < .001) and 1996 and 2005 (HR, 0.53; P = .001) had lower mortality when compared with those diagnosed between 1975 and 1995. Treatment including surgery and chemotherapy tended to have the best survival (P < .001). Conclusion Burkitt’s lymphoma of the head and neck diagnosed in more recent years has had improved survival. Factors significantly associated with survival include age, Ann Arbor stage, and treatment regimen. Treatment including surgery and chemotherapy was associated with the highest survival.
Remote ischemic conditioning improves rat brain antioxidant defense in a time-dependent mechanism

ABSTRACT Purpose To clarify the best protocol for performing remote ischemic conditioning and to minimize the consequences of ischemia and reperfusion syndrome in brain, the present study aimed to evaluate different time protocols and the relation of the organs and the antioxidant effects of this technique. Methods The rat’s left femoral artery was clamped with a microvascular clamp in times that ranged from 1 to 5 minutes, according to the corresponding group. After the cycles of remote ischemic conditioning and a reperfusion of 20 minutes, the brain and the left gastrocnemius were collected. The samples were used to measure glutathione peroxidase, glutathione reductase and catalase levels. Results In the gastrocnemius, the 4-minute protocol increased the catalase concentration compared to the 1-minute protocol, but the latter increased both glutathione peroxidase and glutathione reductase compared to the former. On the other hand, the brain demonstrated higher catalase and glutathione peroxidase in 5-minute group, and the 3-minute group reached higher values of glutathione reductase. Conclusions Remote ischemic conditioning increases brain antioxidant capacity in a time-dependent way, while muscle presents higher protection on 1-minute cycles and tends to decrease its defence with longer cycles of intermittent occlusions of the femoral artery.
Asthma, much more than a respiratory disease: influence of depression and anxiety.

OBJECTIVE The goals of this study are to compare self-reported depression and anxiety in subjects diagnosed of asthma and healthy controls. METHODS We designed a case-control study. Subjects were recruited using a consecutive sampling method from a single institution. Two groups were created: Asthma and healthy controls. Data of medical history and demographic background were collected from the medical record. Self-reported depression level was assessed using Beck's depression inventory (BDI). Self-reported anxiety was measured with the "State-trait anxiety inventory" (STAI). RESULTS Fifty-one subjects with asthma, and fifty healthy patients were included in this study. BDI scores (p<0.001) were higher for asthma (10.22±7.3) than in the control group (5.2±6.56). STAI state (p<0.001) was higher in asthma (42.61±11.5) than in controls (34.88±9.25). STAI trait (p<0.001) showed higher scores in asthma (43.14±10.89) than in controls (34.62±9.19). CONCLUSIONS These study findings showed that BDI, and STAI trait and state scores are significantly higher in subjects who suffer from asthma than healthy controls.
Exogenous corticosterone and melanin-based coloration explain variation in juvenile dispersal behaviour in the barn owl (Tyto alba)

Natal dispersal affects many processes such as population dynamics. So far, most studies have examined the intrinsic and extrinsic factors that determine the distance between the place of birth and of first breeding. In contrast, few researchers followed the first steps of dispersal soon after fledging. To study this gap, we radio-tracked 95 barn owl nestlings (Tyto alba) to locate their diurnal roost sites from the fledging stage until December. This was used to test whether the age of nest departure, post-fledging movements and dispersal distance were related to melanin-based coloration, which is correlated to fitness-related traits, as well as to corticosterone, a hormone that mediates a number of life history trade-offs and the physiological and behavioural responses to stressful situations. We found that the artificial administration of corticosterone delayed the age when juveniles left their parental home-range in females but not in males. During the first few months after fledging, longer dispersal distances were reached by females compared to males, by individuals marked with larger black feather spots compared to individuals with smaller spots, by larger individuals and by those experimentally treated with corticosterone. We conclude that the onset and magnitude of dispersal is sensitive to the stress hormone corticosterone, melanin-based coloration and body size.
Therapeutic immunoglobulin A antibody for dysbiosis-related diseases

Abstract Dysbiosis is alterations in the microbial composition compared with a healthy microbiota and often features a reduction in gut microbial diversity and a change in microbial taxa. Dysbiosis, especially in the gut, has also been proposed to play a crucial role in the pathogenesis of a wide variety of diseases, including inflammatory bowel disease, colorectal cancer, cardiovascular disease, obesity, diabetes and multiple sclerosis. A body of evidence has shown that intestinal polymeric immunoglobulin A (IgA) antibodies are important to regulate the gut microbiota as well as to exclude pathogenic bacteria or viral infection such as influenza and SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) at mucosal sites. Since the 1970s, trials for oral administration of therapeutic IgA or IgG have been performed mainly to treat infectious enteritis caused by pathogenic Escherichia coli or Clostridium difficile. However, few of them have been successfully developed for clinical application up to now. In addition to the protective function against intestinal pathogens, IgA is well known to modulate the gut commensal microbiota leading to symbiosis. Nevertheless, the development of therapeutic IgA drugs to treat dysbiosis is not progressing. In this review, the advantages of therapeutic IgA antibodies and the problems for their development will be discussed.
Local renin angiotensin system and sperm DNA fragmentation

The renin angiotensin system (RAS) appears to influence male fertility at multiple levels. In this work, we analyzed the relationship between the RAS and DNA integrity. Fifty male volunteers were divided into two groups (25 each): control (DNA fragmentation ≤20%) and pathological (DNA fragmentation >20%) cases. Activities of five peptidases controlling RAS were measured fluorometrically: prolyl endopeptidase (which converts angiotensin [A] I and A II to A 1–7), neutral endopeptidase (NEP/CD10: A I to A 1–7), aminopeptidase N (APN/CD13: A III to A IV), aminopeptidase A (A II to A III) and aminopeptidase B (A III to A IV). Angiotensin-converting enzyme (A I to A II), APN/CD13 and NEP/CD10 were also assessed by semiquantitative cytometry and quantitative flow cytometry assays, as were the receptors of all RAS components: A II receptor type 1 (AT1R), A II receptor type 2 (AT2R), A IV receptor (AT4R or insulin-regulated aminopeptidase [IRAP]), (pro)renin receptor (PRR) and A 1–7 receptor or Mas receptor (MasR) None of the enzymes that regulate levels of RAS components, except for APN/CD13 (decrease in fragmented cells), showed significant differences between both groups. Micrographs of RAS receptors revealed no significant differences in immunolabeling patterns between normozoospermic and fragmented cells. Labeling of AT1R (94.3% normozoospermic vs 84.1% fragmented), AT4R (96.2% vs 95.3%) and MasR (97.4% vs 87.2%) was similar between the groups. AT2R (87.4% normozoospermic vs 63.1% fragmented) and PRR (96.4% vs 48.2%) were higher in non-fragmented spermatozoa. These findings suggest that fragmented DNA spermatozoa have a lower capacity to respond to bioactive RAS peptides.
Psychometric properties of the Beck Depression Inventory‐II in progressive supranuclear palsy

Depression is one of the most common neuropsychiatric symptoms in progressive supranuclear palsy (PSP). Yet, few studies have examined the ability of available instruments to detect depressive symptoms in PSP. Aims of the present study were to (I) report psychometric properties of the Beck Depression Inventory Second Edition (BDI‐II) in PSP, (II) establish the BDI‐II cut‐off indicating the presence of depression in PSP and (III) describe clinical correlates as well as correlation with quality of life of depressive symptoms in PSP.
Association Between Body Mass Index and Disability in Children With Charcot-Marie-Tooth Disease

Background and Objectives This study examined the association between body mass index (BMI) and disability in children with Charcot-Marie-Tooth disease (CMT). Methods We conducted a cross-sectional analysis of 477 patients with CMT who were 3 to 20 years of age from the Inherited Neuropathy Consortium and 316 age- and sex-matched healthy children from the 1,000 Norms Project. BMI was categorized according to the International Obesity Task Force (IOTF) criteria, and BMI categorization was compared with healthy children. IOTF categories (adult equivalent BMI cut points) were severely underweight (BMI <17 kg/m2), underweight (BMI ≥17–<18.5 kg/m2), healthy weight (BMI ≥18.5–<25 kg/m2), overweight (BMI ≥25–<30 kg/m2), and obese (BMI ≥30 kg/m2). Scores on the 0 to 44–point CMT Pediatric Scale (CMTPedS), a well-validated measure of disability, were examined in relation to BMI. Results There was a higher proportion of children with CMT categorized as severely underweight (5.7% vs 0.3%), underweight (10.3% vs 5.1%), and obese (7.3% vs 3.8%) (p < 0.05). Fewer children with CMT were categorized as healthy weight (61.8% vs 74.4%) (p < 0.05), and the proportion of overweight (14.9% vs 16.5%) between groups was similar. CMTPedS scores (mean ± SD) for weight categories were as follows: severely underweight 27 ± 9, underweight 20 ± 8, healthy weight 17 ± 9, overweight 17 ± 9, and obese 22 ± 10. Compared to children with a healthy weight with CMT, being severely underweight was associated with being more disabled (p < 0.001), as was being obese (p = 0.015). Discussion The proportion of children with CMT who are underweight or obese is higher compared to age- and sex-matched healthy children. In children with CMT, being underweight or obese is associated with greater disability, when compared to children with CMT of healthy weight.
The clinical impact of paroxysmal arrhythmias on the hospital outcomes of patients admitted with cirrhosis: propensity score matched analysis of 2011–2017 US hospitals

ABSTRACT Background We evaluate the effects of paroxysmal arrhythmia on the hospital outcomes of patients admitted with cirrhosis. Research design and methods 2011–2017 National Inpatient Sample was used to isolate patients with decompensated/compensated cirrhosis, stratified by paroxysmal arrhythmia (supraventricular: PSVT and ventricular: PVT). The cohorts were matched using propensity-score matching and compared to mortality, length of stay, cost, and cardiac complications (cardioversion, cardiogenic shock, cardiac arrest, and ventricular fibrillation). Results In compensated cirrhosis, 2,453 had PSVT with matched controls; 5,274 had PVT with matched controls. Those with PSVT had higher mortality (aOR 1.55 95%CI 1.23–1.95) and higher rates of cardioversion and cardiogenic shock; likewise, those with PVT had higher mortality (aOR 2.41 95%CI 2.09–2.78) and higher rates of all complications. In decompensated cirrhosis, 1,598 had PSVT with matched controls; 4,178 had PVT with matched controls. Those with PSVT had higher mortality (aOR 1.57 95%CI 1.28–1.93) and higher rates of cardioversion, cardiogenic shock, cardiac arrest; those with PVT had higher mortality (aOR 2.25 95%CI 1.98–2.56) and higher rates of all complications. Conclusion The findings from this study show that in either decompensated or compensated cohort, those with paroxysmal arrhythmias are at a higher risk of in-hospital mortality and adverse cardiac outcomes.
A Dual-Channel Framework for Sarcasm Recognition by Detecting Sentiment Conflict

Sarcasm employs ambivalence, where one says something positive but actually means negative, and vice versa. The essence of sarcasm, which is also a sufficient and necessary condition, is the conflict between literal and implied sentiments expressed in one sentence. However, it is difficult to recognize such sentiment conflict because the sentiments are mixed or even implicit. As a result, the recognition of sophisticated and obscure sentiment brings in a great challenge to sarcasm detection. In this paper, we propose a Dual-Channel Framework by modeling both literal and implied sentiments separately. Based on this dual-channel framework, we design the Dual-Channel Network~(DC-Net) to recognize sentiment conflict. Experiments on political debates (i.e. IAC-V1 and IAC-V2) and Twitter datasets show that our proposed DC-Net achieves state-of-the-art performance on sarcasm recognition. Our code is released to support research.
Impaired interaural correlation processing in people with schizophrenia

Detection of transient changes in interaural correlation is based on the temporal precision of the central representations of acoustic signals. Whether schizophrenia impairs the temporal precision in the interaural correlation process is not clear. In both participants with schizophrenia and matched healthy‐control participants, this study examined the detection of a break in interaural correlation (BIC, a change in interaural correlation from 1 to 0 and back to 1), including the longest interaural delay at which a BIC was just audible, representing the temporal extent of the primitive auditory memory (PAM). Moreover, BIC‐induced electroencephalograms (EEGs) and the relationships between the early binaural psychoacoustic processing and higher cognitive functions, which were assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), were examined. The results showed that compared to healthy controls, participants with schizophrenia exhibited poorer BIC detection, PAM and RBANS score. Both the BIC‐detection accuracy and the PAM extent were correlated with the RBANS score. Moreover, participants with schizophrenia showed weaker BIC‐induced N1‐P2 amplitude which was correlated with both theta‐band power and inter‐trial phase coherence. These results suggested that schizophrenia impairs the temporal precision of the central representations of acoustic signals, affecting both interaural correlation processing and higher‐order cognitions.
A Comparison of 2D Magnetohydrodynamic Supernova Simulations with the CoCoNuT-FMT and Aenus-Alcar Codes

Code comparisons are a valuable tool for the verification of supernova simulation codes and the quantification of model uncertainties. Here we present a first comparison of axisymmetric magnetohydrodynamic (MHD) supernova simulations with the CoCoNuT-FMT and Aenus-Alcar codes, which use distinct methods for treating the MHD induction equation and the neutrino transport. We run two sets of simulations of a rapidly rotating 35M gamma-ray burst progenitor model with different choices for the initial field strength, namely 1012 G for the maximum poloidal and toroidal field in the strong-field case and 1010 G in the weak-field case. We also investigate the influence of the Riemann solver and the resolution in CoCoNuT-FMT. The dynamics is qualitatively similar for both codes and robust with respect to these numerical details, with a rapid magnetorotational explosion in the strong-field case and a delayed neutrino-driven explosion in the weak-field case. Despite relatively similar shock trajectories, we find sizeable differences in many other global metrics of the dynamics, like the explosion energy and the magnetic energy of the proto-neutron star. Further differences emerge upon closer inspection, for example, the disk-like surface structure of the proto-neutron star proves highly sensitives to numerical details. The electron fraction distribution in the ejecta as a crucial determinant for the nucleosynthesis is qualitatively robust, but the extent of neutronor proton-rich tails is sensitive to numerical details. Due to the complexity of the dynamics, the ultimate cause of model differences can rarely be uniquely identified, but our comparison helps gauge uncertainties inherent in current MHD supernova simulations.
Video2Skill: Adapting Events in Demonstration Videos to Skills in an Environment using Cyclic MDP Homomorphisms

Humans excel at learning long-horizon tasks from demonstrations augmented with textual commentary, as evidenced by the burgeoning popularity of tutorial videos online. Intuitively, this capability can be separated into 2 distinct subtasks - first, dividing a long-horizon demonstration sequence into semantically meaningful events; second, adapting such events into meaningful behaviors in one's own environment. Here, we present Video2Skill (V2S), which attempts to extend this capability to artificial agents by allowing a robot arm to learn from human cooking videos. We first use sequence-to-sequence Auto-Encoder style architectures to learn a temporal latent space for events in long-horizon demonstrations. We then transfer these representations to the robotic target domain, using a small amount of offline and unrelated interaction data (sequences of state-action pairs of the robot arm controlled by an expert) to adapt these events into actionable representations, i.e., skills. Through experiments, we demonstrate that our approach results in self-supervised analogy learning, where the agent learns to draw analogies between motions in human demonstration data and behaviors in the robotic environment. We also demonstrate the efficacy of our approach on model learning - demonstrating how Video2Skill utilizes prior knowledge from human demonstration to outperform traditional model learning of long-horizon dynamics. Finally, we demonstrate the utility of our approach for non-tabula rasa decision-making, i.e, utilizing video demonstration for zero-shot skill generation.
Increasing the Enrollment, Retention, and Graduation of Undergraduate Women Majoring in Computing

Increasing the participation of women in undergraduate computing requires a multi-pronged, systemic approach that include strategic student recruitment, teaching practices, program curriculum, student support, high-level institutional policies and support, and evaluation of initiatives. The Extension Services for Undergraduate Program (ES-UP) at the National Center for Women & Information Technology (NCWIT) employs this systemic approach for changing the way students experience computing majors and has yielding notable success; computing departments that participated in ES-UP steadily increased the percentage of women declared majors from 12% in 2008 to 23% in 2019, ES participants steadily increased the retention rate of women declared computing majors from 77% in 2008 to 88% in 2017, and the percentage of degrees awarded to women steadily increased from 12% in 2008 to 22% in 2019. Moreover, ES participants continue to make progress over time. The greater the number of years since ES-UP consultation and implementing our systemic change strategies, the greater the progress in women declared majors and graduates with bachelor’s degrees in computing. While the results in this paper focus on computing departments, the recruitment and retention recommendations are applicable to engineering and other STEM disciplines where women are severely underrepresented.
Entanglement Wedge Cross-Section for Holographic Aether Gravity

Gravity Chong-Ye Chen 1,∗ Wei Xiong 1,† Chao Niu 1,‡ Cheng-Yong Zhang 1,§ and Peng Liu 1¶ 1 Department of Physics and Siyuan Laboratory, Jinan University, Guangzhou 510632, China Abstract We study the entanglement wedge cross-section (EWCS) in holographic Aether gravity theory, a gravity theory with Lorentz symmetry breaking meanwhile keeping the general covariance intact. We find that only a limited parameter space is allowed to obtain a black brane with positive Hawking temperature. Subject to these allowed parameter regions, we find that the EWCS could exhibit non-monotonic behaviors with system parameters. Meanwhile, the holographic entanglement entropy (HEE), and the corresponding mutual information (MI), can only exhibit monotonic behaviors. These phenomena suggest that the EWCS could capture much more rich content of the entanglement than that of the HEE and the MI. The role of the Lorentz violation in determining the behaviors of quantum information-related quantities is also analyzed.
Fecal microbiota transplantation for immunotherapy‐resistant urological tumors: Is it time? An update of the recent literature

INTRODUCTION The human gastrointestinal tract harbors a complex and dynamic population of microorganisms called the gut microbiota, which plays an important role in immunological, metabolic, and structural landscapes of the human body. Modulation strategies for the gut microbiota seem, therefore, to contribute to the understanding of disorders related to its impairment. Fecal microbiota transplantation (FMT) is one of these modulation strategies. FMT is commonly used for refractory Clostridium difficile infections, inflammatory bowel disorders, metabolic disorders, and liver cirrhosis. Because the gut microbiota is a potential modulator of responses to immune checkpoint inhibitors (ICIs), FMT has been studied in the last decade, with transplants taken from healthy individuals to “refresh” the status of the gut microbiota or taken from individuals responding to ICIs and placed into nonresponders. Recent findings have proved the efficacy of FMT in reversing resistance to ICIs in patients with melanoma. However, this reversalofresistance effect has not yet been applied to urological tumors. The current evidence shows that human gut microbiota may hold a pivotal role in genitourinary cancer initiation and treatment response, and it influences the development of urological tumors, including urothelial carcinoma (UC), renal cell carcinoma (RCC), and prostate cancer (PCa). The aim of this commentary is to highlight the potential for FMT in urological tumors (UC, RCC, and PCa) resistant to ICIs and to provide the evidence behind this distinct breakthrough.