Miracle-dz/UniFAR-FTUs huggingface dataset:
Arrhythmia classification of 12-lead and reduced-lead electrocardiograms via recurrent networks, scattering, and phase harmonic correlation

We describe an automatic classifier of arrhythmias based on 12-lead and reduced-lead electrocardiograms. Our classifier comprises four modules: scattering transform (ST), phase harmonic correlation (PHC), depthwise separable convolutions (DSC), and a long short-term memory (LSTM) network. It is trained on PhysioNet/Computing in Cardiology Challenge 2021 data. The ST captures short-term temporal ECG modulations while the PHC characterizes the phase dependence of coherent ECG components. Both reduce the sampling rate to a few samples per typical heart beat. We pass the output of the ST and PHC to a depthwise-separable convolution layer (DSC) which combines lead responses separately for each ST or PHC coefficient and then combines resulting values across all coefficients. At a deeper level, two LSTM layers integrate local variations of the input over long time scales. We train in an end-to-end fashion as a multilabel classification problem with a normal and 25 arrhythmia classes. Lastly, we use canonical correlation analysis (CCA) for transfer learning from 12-lead ST and PHC representations to reduced-lead ones. After local cross-validation on the public data from the challenge, our team ‘BitScattered’ achieved the following results: 0.682 ± 0.0095 for 12-lead; 0.666 ± 0.0257 for 6-lead; 0.674 ± 0.0185 for 4-lead; 0.661 ± 0.0098 for 3-lead; and 0.662 ± 0.0151 for 2-lead.
The domains of yeast eIF4G, eIF4E and the cap fine-tune eIF4A activities through an intricate network of stimulatory and inhibitory effects

Abstract Translation initiation in eukaryotes starts with the recognition of the mRNA 5′-cap by eIF4F, a hetero-trimeric complex of eIF4E, the cap-binding protein, eIF4A, a DEAD-box helicase, and eIF4G, a scaffold protein. eIF4G comprises eIF4E- and eIF4A-binding domains (4E-BD, 4A-BD) and three RNA-binding regions (RNA1–RNA3), and interacts with eIF4A, eIF4E, and with the mRNA. Within the eIF4F complex, the helicase activity of eIF4A is increased. We showed previously that RNA3 of eIF4G is important for the stimulation of the eIF4A conformational cycle and its ATPase and helicase activities. Here, we dissect the interplay between the eIF4G domains and the role of the eIF4E/cap interaction in eIF4A activation. We show that RNA2 leads to an increase in the fraction of eIF4A in the closed state, an increased RNA affinity, and faster RNA unwinding. This stimulatory effect is partially reduced when the 4E-BD is present. eIF4E binding to the 4E-BD then further inhibits the helicase activity and closing of eIF4A, but does not affect the RNA-stimulated ATPase activity of eIF4A. The 5′-cap renders the functional interaction of mRNA with eIF4A less efficient. Overall, the activity of eIF4A at the 5′-cap is thus fine-tuned by a delicately balanced network of stimulatory and inhibitory interactions.
Instructions to shift eyes do not increase item-method directed forgetting

ABSTRACT Successful forgetting of recently-studied information has been shown to be positively correlated with eye movements [Lee, Y. (2018). Withdrawal of spatial overt attention following intentional forgetting: Evidence from eye movements. Memory (Hove, England), 26(4), 503–513. https://doi.org/10.1080/09658211.2017. 1378360]. We tested whether eye movements caused forgetting by manipulating instructions to move eyes following forget and remember cues in item-method directed forgetting. In Experiment 1, participants were instructed to move eyes to the periphery after TBF trials or to focus on the centre where the TBF word and cue had been presented. In Experiment 2, we manipulated eye movement instructions within participants such that on half of the TBR and TBF trials participants shifted their eyes to the periphery, and on the other half of the trials, participants focused on the centre of the screen. Experiment 3 replicated Experiment 2 with an added probe task which ensured participants were moving their eyes as instructed. Results overall showed eye movements did not increase directed forgetting. Instructing participants to shift or focus eyes did not interact with the effectiveness of directed forgetting. Furthermore, metacognitive measures collected during study indicated that participants are sensitive to the significant effects of directed forgetting, but – like recall – judgments were not affected by eye movement instructions. From these findings, we concluded that eye movements do not promote intentional forgetting.
EURO-MUSCULUS/USPRM Dynamic Ultrasound Protocols for (Adult) Hip.

ABSTRACT In this dynamic scanning protocol, ultrasound assessment of the adult hip is described using different maneuvers for various conditions. Real-time patient examination and ultrasound scanning videos are coupled for convenience as well as for better insight. The text covers the common conditions around the hip where especially dynamic ultrasound scanning provides valuable information in addition to static imaging. The protocol is prepared by an international consensus of several experts in the field of musculoskeletal ultrasound.
Using TikTok for public and youth mental health – A systematic review and content analysis

Globally, TikTok is now the fastest growing social media platform among children and young people; but it remains surprisingly under-researched in psychology and psychiatry. This is despite the fact that social media platforms have been subject to intense academic and societal scrutiny regarding their potentially adverse effects on youth mental health and wellbeing, notwithstanding the inconsistent findings across the literature. In this two part study, we conducted a systematic review concerning studies that have examined TikTok for any public health or mental health purpose; and a follow-up content analysis of TikTok within an Irish context. For study 1, a predetermined search strategy covering representative public and mental health terminology was applied to six databases – PSYCINFO, Google Scholar, PUBMED, Wiley, Journal of Medical Internet Research, ACM – within the period 2016 to 2021. Included studies were limited to English-speaking publications of any design where TikTok was the primary focus of the study. The quality appraisal tool by Dunne et al., (2018) was applied to all included studies. For study 2, we replicated our search strategy from study 1, and converted this terminology to TikTok hashtags to search within TikTok in combination with Irish-specific hashtags. As quantified by the app, the top two “most liked” videos were selected for inclusion across the following three targeted groups: official public health accounts; registered Irish charities; and personal TikTok creators. A full descriptive analysis was applied in both studies. Study 1 found 24 studies that covered a range of public and mental health issues: COVID-19 (n = 10), dermatology (n = 7), eating disorders (n = 1), cancer (n = 1), tics (n = 1), radiology (n = 1), sexual health (n = 1), DNA (n = 1), and public health promotion (n = 1). Studies were predominately from the USA, applied a content analysis design, and were of acceptable quality overall. In study 2, 29 Irish TikTok accounts were analysed, including the accounts of public health authorities (n = 2), charity or non-profit (n = 5), and personal TikTok creators (n = 22). The overall engagement data from these accounts represented a significant outreach to younger populations: total likes n = 2,588,181; total comments n = 13,775; and total shares n = 21,254. TikTok has been utilised for a range of public health purposes, but remains poorly engaged by institutional accounts. The various mechanisms for connecting with younger audiences presents a unique opportunity for youth mental health practitioners to consider, yet there were distinct differences in how TikTok accounts used platform features to interact. Overall, there is an absence of high quality mixed methodological evaluations of TikTok content for public and mental health, despite it being the most used platform for children and young people.
The conundrum in endoscopic management of duodenal polyps: a tertiary cancer center experience

ABSTRACT Background Endoscopic mucosal resection of duodenal polyps (EMR) is a challenging intervention. The aim of this study was to review the patient characteristics, techniques, procedure outcomes, adverse events, and recurrence of duodenal polyps. Research Design and Methods Patients were included if they had pathologically confirmed non-ampullary duodenal polyps and had received EMR with at least one follow-up EGD for surveillance. Descriptive statistics were employed to report the findings. Results A total of 65 patients underwent a total of 90 EMRs for duodenal polyps. The mean age was 65.4 years, and 29 of the patients were female. Complete resection of the visible mass was achieved in 96.9% of cases. Endoscopic hemostasis was required in 18.5% of patients. Delayed bleeding occurred in 9%, and delayed perforations requiring surgical intervention occurred in 2.2% of patients with no mortality. Surgery after EMR was needed in 12.7% of cases. Eleven (16.9%) patients had recurrent duodenal adenoma on follow-up EGD. Conclusion Duodenal polyps can be safely resected and have a notable recurrence rate. This is particularly true for adenomas, warranting post-resection endoscopic surveillance. The appropriate interval for post-resection surveillance of duodenal adenomas should be a focus of future study.
Use of Nonlinear Frequency Modulated Signals for the Enhancement of Subharmonic Response from Contrast Microbubbles

Ultrasound imaging with the subharmonic component from contrast microbubbles provide improved CTR (Contrast-to-Tissue Ratio), however it is susceptible to the low amplitude of the subharmonic component. In this simulation study, NLFM (Nonlinear Frequency Modulated) signals are proposed in order to enhance the subharmonic response from microbubbles. NLFM signals having fractional bandwidths of 10, 20, and 40% with up and down sweeps were used as excitation. The performance of NLFM signals were compared with the reference tone-burst and LFM (Linear Frequency Modulated) signals. The results show that the ultrasound contrast microbubbles can produce subharmonic response which is dependent on the applied signal pressure and bandwidth. It is observed that the subharmonic component of the scattered NLFM signal is 3.2dB higher than the LFM signal, whereas it is 9dB higher compared to the sinusoidal tone-burst signal. The results are also presented which show that the up and down sweeps NLFM signals performed better than the LFM signals at the same acoustic pressure and bandwidth.
Development of a multidisciplinary clinical approach for unexplained regression in Down syndrome

Programs in Multiple Sclerosis and Neuroimmunology, Department of Neurology, Boston Children's Hospital, Boston, Massachusetts, USA Kennedy Krieger Institute, Baltimore, Maryland, USA Down Syndrome Program, Developmental Medicine Center, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA Department of Psychiatry, Boston Children's Hospital, Boston, Massachusetts, USA Department of Neurology, Boston Children's Hospital, Boston, Massachusetts, USA
Photodynamic therapy and combinatory treatments for the control of biofilm‐associated infections

The advent of antimicrobial resistance has added considerable impact to infectious diseases both in the number of infections and healthcare costs. Furthermore, the relentless emergence of multidrug‐resistant bacteria, particularly in the biofilm state, has made mandatory the discovery of new alternative antimicrobial therapies that are capable to eradicate resistant bacteria and impair the development of new forms of resistance. Amongst the therapeutic strategies for treating biofilms, antimicrobial photodynamic therapy (aPDT) has shown great potential in inactivating several clinically relevant micro‐organisms, including antibiotic‐resistant ‘priority bacteria’ declared by the WHO as critical pathogens. Its antimicrobial effect is centred on the basis that harmless low‐intensity light stimulates a non‐toxic dye named photosensitizer, triggering the production of reactive oxygen species upon photostimulation. In addition, combination therapies of aPDT with other antimicrobial agents (e.g. antibiotics) have also drawn considerable attention, as it is a multi‐target strategy. Therefore, the present review highlights the recent advances of aPDT against biofilms, also covering progress on combination therapy.
Reliability analysis of man–machine systems using fuzzy cognitive mapping with genetic tuning

This article offers a method for analyzing the reliability of a man–machine system (MMS) and ranking of influencing factors based on a fuzzy cognitive map (FCM). The ranking of influencing factors is analogous to the ranking of system elements the probabilistic theory of reliability. To approximate the dependence of “influencing factors—reliability,” the relationship of variable increments is used, which ensures the sensitivity of the reliability level to variations in the levels of influencing factors. The novelty of the method lies in the fact that the expert values of the weights of the FCM graph edges (arcs) are adjusted based on the results of observations using a genetic algorithm. The algorithm's chromosomes are generated from the intervals of acceptable values of edge weights, and the selection criterion is the sum of squares of deviations of the reliability simulation results from observations. The method is illustrated by the example of a multifactor analysis of the reliability of the “driver–car–road” system. It is shown that the FCM adjustment reduces the discrepancy between the reliability forecast and observations almost in half. Possible applications of the method can be complex systems with vaguely defined structures whose reliability depends very much on interrelated factors measured expertly.
'Inclusive Design Research Initiatives at the Royal College of Art'Book in Universal Design Handbook (2nd Edition),

Thoroughly updated and packed with examples of global standards and design solutions, Universal Design Handbook, Second Edition, covers the full scope of universal design, discussing how to develop media, products, buildings, and infrastructure for the widest range of human needs, preferences, and functioning. This pioneering work brings together a rich variety of expertise from around the world to discuss the extraordinary growth and changes in the universal design movement. The book provides an overview of universal design premises and perspectives, and performance-based design criteria and guidelines. Public and private spaces, products, and technologies are covered, and current and emerging research and teaching are explored. This unique resource includes analyses of historical and contemporary universal design issues from seven different countries, as well as a look at future trends.
Discussion note: Did Darwin really answer Paley's question?

: It is commonly thought that natural selection explains the rise of adaptive complexity. Razeto-Barry and Frick (2011) have recently argued in favour of this view, dubbing it the Creative View. I argue that the Creative View is mistaken if it claims that natural selection serves to answer Paley’s question. This is shown by a case that brings out the contrastive structure inherent in this demand for explanation. There is, however, a rather trivial sense in which specific environmental conditions are crucial for the rise of specific adaptations, but this is hardly what opponents of the Creative View are denying.
Receding-Horizon Pseudo-spectral Control of Wave Energy Converters Using Periodic Basis Functions

Power-maximizing control of wave energy converters (WECs) can be implemented within a receding-horizon (RH) framework, whereby the reference force or velocity trajectory is updated in real-time by a feed-forward control (FFC) algorithm. For the computation of optimal WEC trajectories and control forces, Fourier pseudo-spectral (PS) control, using periodic basis functions, is simple and computationally attractive, for both linear and non-linear WEC dynamics. However, the finite-length wave excitation signal, as seen by the FFC, is in general non-periodic. In this paper, it is shown that, despite the non-periodicity of the input wave signal, a simple Fourier PS method can be successfully used as an FFC algorithm, by applying suitable windowing functions to the input signal when necessary. Furthermore, a simple wave forecasting algorithm is introduced, solely based on past values of the wave excitation, and the impact of wave forecast errors on the controller performance is investigated. Overall, with or without forecast errors, the proposed approach allows for power absorption above 99% of the optimum, for a forecasting horizon of less than 30 s for a linear WEC model, and less than 15 s for a non-linear WEC model including a quadratic viscous drag term.
Optimization of user experience in interaction design through a Taguchi‐based hybrid approach

User experience (UX), which encompasses all aspects of a user’s interaction with an interactive product, has been recognized as central to interaction design. This paper proposes a Taguchi‐based hybrid approach to realize the optimal UX design. In this approach, design analysis is first used to identify design patterns and UX characteristics. According to the results, a Taguchi experiment is conducted and the signal‐to‐noise ratios are computed. Subsequently, the preference weights for the UX characteristics are obtained by using analytical hierarchy process‐based group decision making. A multiperformance characteristic index is then defined based on the gray relational grade (GRG) obtained through gray relational analysis. On the basis of the GRG, the optimal design can be obtained. A mobile health application design was used to demonstrate the proposed approach. The results show that this approach can effectively enhance UX quality and be used as a universal design approach for optimizing UX.
Online Monitoring And Simulation Of 30KW Grid Connected Rooftop Solar Power Plant At St.Peter’s International School, Hyderabad using PV Syst

In grid connected rooftop solar PV system, available rooftop area on buildings is used for setting up solar power plant and DC power generated from solar photovoltaic (SPV) cells is converted to AC power by solar grid inverter and is fed to the grid during day time. In night when solar power is not sufficient, loads are served by drawing power from grid. In this paper, real time monitoring and Simulation analysis of 30KW solar photovoltaic roof top grid connected power plant at St.Peter’s International School, Hyderabad city is carried out using PV Syst simulation software. The real time meter readings on import side and export side of energy and energy output of inverter are recorded. The simulation results of energy output of PV array, energy output of inverter and energy injected into grid are presented. The annual average solar radiation at St.Peter’s International School is 5.87 kWh/m2/day. The performance ratio and PV losses due to irradiance level are calculated using PVSyst software
Dispositivo Robótico Multifuncional para la Rehabilitación de las Extremidades Superiores

En este trabajo se presenta un dispositivo de rehabilitacion innovador por su flexibilidad y eficiencia denominado Universal Haptic Pantograph (UHP). Este robot, gracias a su estructura multi-configurable permite la rehabilitacion del miembro superior con un unico dispositivo. Ademas, se ha disenado con la habilidad de realizar diferentes tareas asistivas y resistivas, pudiendo asi adaptarse al estado de recuperacion del paciente. Finalmente, el software Telereha genera un entorno de realidad virtual que facilita la ejecucion del ejercicio y aumenta la motivacion del paciente. El sistema de control del robot se ha implementado entiempo real con el fin de garantizar la correcta ejecucion de las tareas de rehabilitacion. Usando este sistema, se han realizado diferentes ensayos experimentales. Los resultados demuestran que el robot de rehabilitacion UHP funciona correctamente con diferentes tareas de rehabilitacion, realizando movimientos suaves y seguros que garantizan la seguridad del usuario.
How different are the regional factors of high-tech and low-tech start-ups? from Japanese

This paper analyzes regional determinants of the start-up ratio in the Japanese manufacturing sector. A major contribution of this study is the comparison between high-tech and low-tech industries. The empirical results using a sample of 253 industrial districts suggest that business density, weight of the manufacturing sector, and the average business size significantly influence the start-up ratio in both high-tech and low-tech industries. Distinct differences between these industries were found with regard to the effects of human capital, research institutes, and the weight of high-tech industries.
Digital fringe projection for hand surface coordinate variation analysis caused by osteoarthritis

Hand osteoarthritis is one of the most common forms of arthritis which impact millions of people worldwide. The disabling problem occurs when the protective cartilage on the boundaries of bones wear off over time. Currently, in order to identify hand osteoarthritis, special instruments namely X-ray scanning and MRI are used for the detection but it also has its limitations such as radiation exposure and can be quite costly. In this work, an optical metrology system based on digital fringe projection which comprises of an LCD projector, CCD camera and a personal computer has been developed to anticipate abnormal growth or deformation on the joints of the hand which are common symptoms of osteoarthritis. The main concept of this optical metrology system is to apply structured light as imaging source for surface change detection. The imaging source utilizes fringe patterns generated by C++ programming and is shifted by 3 phase shifts based on the 3 steps 2 shifts method. Phase wrapping technique and analysis were applied in order to detect the deformation of live subjects. The result has demonstrated a successful method of hand deformation detection based on the pixel tracking differences of a normal and deformed state.
3D Printed High Gain Complementary Dipole/Slot Antenna Array

By employing the complementary dipole antenna concept to the normal waveguide fed slot radiator, an improved antenna element with wide impedance bandwidth and symmetrical radiation patterns is developed. This is achieved by mounting two additional metallic cuboids on the top of the slot radiator, which is equivalent to adding an electric dipole on top of the magnetic dipole due to the slot radiator. Then, a high-gain antenna array was designed based on the improved element and fabricated, using 3D printing technology, with stable frequency characteristics operated at around 28 GHz. This was followed by metallization via electroplating. Analytical results agree well with the experimental results. The measured operating frequency range for the reflection coefficient ≤−15 dB is from 25.7 GHz to 29.8 GHz; its corresponding fractional impedance bandwidth is 14.8%. The measured gain is approximately 32 dBi, with the 3 dB beamwidth around 4°.