Miracle-dz/UniFAR-FTUs huggingface dataset:
Self-evaluation of social-rank in socially anxious individuals associates with enhanced striatal reward function

Abstract Background Negative self-views, especially in the domain of power (i.e. social-rank), characterize social anxiety (SA). Neuroimaging studies on self-evaluations in SA have mainly focused on subcortical threat processing systems. Yet, self-evaluation may concurrently invoke diverse affective processing, as motivational systems related to desired self-views may also be activated. To investigate the conflictual nature that may accompany self-evaluation of certain social domains in SA, we examined brain activity related to both threat and reward processing. Methods Participants (N = 74) differing in self-reported SA-severity underwent fMRI while completing a self-evaluation task, wherein they judged the self-descriptiveness of high- v. low-intensity traits in the domains of power and affiliation (i.e. social connectedness). Participants also completed two auxiliary fMRI tasks designated to evoke reward- and threat-related activations in the ventral striatum (VS) and amygdala, respectively. We hypothesized that self-evaluations in SA, particularly in the domain of power, involve aberrant brain activity related to both threat and reward processing. Results SA-severity was more negatively associated with power than with affiliation self-evaluations. During self-evaluative judgment of high-power (e.g. dominant), SA-severity associated with increased activity in the VS and ventromedial prefrontal cortex. Moreover, SA-severity correlated with higher similarity between brain activity patterns activated by high-power traits and patterns activated by incentive salience (i.e. reward anticipation) in the VS during the reward task. Conclusions Our findings indicate that self-evaluation of high-power in SA involves excessive striatal reward-related activation, and pinpoint the downregulation of VS-VMPFC activity within such self-evaluative context as a potential neural outcome for therapeutic interventions.
Highly improved performance in Zr0.5Hf0.5O2 films inserted with graphene oxide quantum dots layer for resistive switching non-volatile memory

Resistive memory (RRAM) based on a solid–electrolyte insulator is a type of critical nanoscale device with promising potential in non-volatile memory, analog circuits and neuromorphic synapse applications. However, the random nature of the nucleation and growth of the conductive filaments (CFs) causes instability of the switching parameter, which is a major obstacle for RRAM performance improvement. Herein, we report a novel approach to resolve this challenge by inserting graphene oxide quantum dots (GOQDs) in Zr0.5Hf0. 5O2 (ZHO) films. The Ag/ZHO/GOQDs/ZHO/Pt stacked device exhibited a reversible bipolar resistive switching (RS) behavior under a direct current (DC) sweeping voltage. The device with GOQDs exhibited better performance than the device without GOQDs with characteristics such as reduced threshold voltage, uniform distribution of set and reset voltage, robust retention, fast switching speed and low switching power. The underlying RS mechanism of RRAM was ascribed to the formation and rupture of the nanoscale CFs inside the solid–electrolyte oxide layer. The GOQDs could guide the CF nucleation and growth direction to provide a superior uniformity of RS properties and shorten the effective distance of Ag+ motion through enhancing the local electric field on the GOQD sites. The overall device performance of the GOQDs-inserted memristor has the potential to open up a new route to improve the reliability of oxide-based RRAM, which could significantly accelerate their existing applications.
On the relationship between intrinsic and extrinsic work motivation

Monetary rewards and supervision crowd out intrinsic work motivation (work morale) under identifiable and relevant conditions. Work performance decreases if this crowding effect dominates the normally considered disciplining effect of external interventions. The crowding out effect is supported by experimental and econometric evidence. Crowding theory allows to explain empirical observations contradicting principal-agent theory such as why pay-for-pcrformance is so little used, why bonding is virtually never observed, and why managers of for-profit institutions receive part of their salary in terms of bonuses, while managers in not-for-profit institutions receive a fixed payment.
A Member of the Transdisciplinary Prostate Cancer Partnership (TopCaP)

Recent therapeutic strategies for different cancer types have focused on targeting immune check-points, such as programmed death-1 (PD-1) and its ligand PD-L1. However, it was recently reported that men with castration-resistant prostate cancer did not respond to PD-1 blockade as monotherapy. The unresponsiveness could potentially be explained by low expression of PD-L1 on prostate tumor cells. This study investigated the expression of PD-L1 on tumor cells and tumor infiltrating lymphocytes (TILs) in men with primary prostate cancer.
Sécurité haut débit pour les systèmes embarqués à base de FPGAs

" [. ] Puis, l'on ferra des recepteurs de television bijoux, comme il y a des postes de TSF bijoux. Des postes de poches, grands comme une lampe electrique. Plus besoin d'acheter un journal, l'on se branchera sur l'emission d'information, ou sur l'editorial politique, ou sur la chronique de mode, ou sur le compte rendu sportif. Voir meme sur un probleme de mots croises. Et la rue presentera un singulier spectacle. " R. Barjavel, " La television, oeil de demain ", 1947. C'est ainsi que l'auteur de romans de science fiction et d'anticipation Rene Barjavel, avait predit des la fin des annees 40 l'avenement de ce que nous connaissons sous le nom de smartphones. Drole de scene, en effet, que de voir des individus deambuler dans les rues, les yeux rives sur l'objet au creux de leur main. Pour le meilleur et pour le pire, l'avenement de la mise en reseau a l'echelle mondiale a rendu les systemes embarques omnipresents dans notre quotidien. Desormais dans le nuage, le nombre d'information personnel en transit et les vitesses de transfert toujours plus importants, imposent une securite adequate. Cependant, le cout en general associe est economiquement dissuasif. Proposer des solutions de securite ad-hoc pour ces systemes restreints en ressources, est le propos de nos travaux. S'appuyant sur des techniques a la fois anciennes et recentes, nous montrons que le couple embarque/securite peut s'accorder, et eviter ainsi, une inevitable procedure de divorce.
against Leprosy Functional Responses of TLR1 but Protects Impairs Cell Surface Trafficking and Cutting Edge: A Common Polymorphism

TLRs constitute an essential family of pattern recognition molecules that, through direct recognition of conserved microbial components, initiate inflammatory responses following infection. In this role, TLR1 enables host responses to a variety of bacteria, including pathogenic species of mycobacteria. In this study, we report that I602S, a common single nucleotide polymorphism within TLR1, is associated with aberrant trafficking of the receptor to the cell surface and diminished responses of blood monocytes to bacterial agonists. When expressed in heterologous systems, the TLR1 602S variant, but not the TLR1 602I variant, exhibits the expected deficiencies in trafficking and responsiveness. Among white Europeans, the 602S allele represents the most common single nucleotide polymorphism affecting TLR function identified to date. Sur-prisingly, the 602S allele is associated with a decreased incidence of leprosy, suggesting that Mycobacterium leprae subverts the TLR system as a mechanism of immune evasion. The Journal of Immunology, 2007, 178: 7520–7524.
Influenza Virus-Infected Cells

Influenza virus infection has adverse effects on the metabolism of two representative RNA polymerase II transcripts in chicken embryo fibroblasts, those coding for Il-actin and for avian leukosis virus (ALV) proteins. Proviral ALV DNA was integrated into host cell DNA by prior infection with ALV. Within 1 h after influenza virus infection, the rate of transcription of I-actin and ALV sequences decreased 40 to 60%, as determined by labeling the cells for 5 min with [3H]uridine and by in vitro, runoff assays with isolated nuclei. The transcripts that continued to be synthesized did not appear in the cytoplasm as mature mRNAs, and the kinetics of labeling of these transcripts strongly suggest that they were degraded in the nucleus. By Sl endonuclease assay, it was confirmed that nuclear ALV transcripts disappeared very early after infection, already decreasing ca. 80% by 1 h postinfection. A plausible explanation for this nuclear degradation is that the viral cap-dependent endonuclease in the nucleus cleaves the 5' ends of new polymerase II transcripts, rendering the resulting decapped RNAs susceptible to hydrolysis by cellular nucleases. In contrast to the nuclear transcripts, cytoplasmic ,I-actin and ALV mRNAs, which are synthesized before infection, were more stable and did not decrease in amount until after 3 h postinfection. Similar stability of cytoplasmic host cell mRNAs was observed in infected HeLa cells, in which the levels of actin mRNA and two HeLa cell mRNAs (pHe 7 and pHe 28) remained at undiminished levels for 3 h of infection and decreased only slightly by 4.5 h postinfection. The cytoplasmic actin and pHe 7 mRNAs isolated from infected HeLa cells were shown to be translated in reticulocyte extracts in vitro, indicating that host mRNAs were not inactivated by a virus-induced modification. Despite the continued presence of high levels of functional host cell mRNAs, host cell protein synthesis was effectively shut off by about 3 h postinfection in both chicken embryo fibroblasts and HeLa cells. These results are consistent with the establishment of an influenza virus-specific translational system that selectively translates viral and not host mRNAs.
Delft University of Technology A High-Linearity and Low-EMI Multilevel Class-D Amplifier

This paper presents a Class-D audio amplifier for automotive applications. Low EMI and, hence, smaller LC filter size is obtained by employing a fully differential multilevel output stage switching at 4.2 MHz. A modulation scheme with minimal switching activity at zero input reduces idle power, which is further assisted by a gate-charge reuse scheme. It also achieves high linearity thanks to the high loop gain realized by a 3rd-order feedback loop with a bandwidth of 800 kHz. The prototype, fabricated in a 180 nm high-voltage BCD process, achieves a minimum THD+N of −107.8 dB/−102 dB and a peak efficiency of 91%/87% with an 8-Ω and a 4-Ω load, respectively, while drawing 7 mA quiescent current from a 14.4 V supply. The prototype meets the CISPR 25 Class 5 EMI standard with a 5.7 dB margin using an LC filter with a cutoff frequency of 580 kHz.
HEART BEAT MONITORING SYSTEM USING HEART RATE SENSOR (PIC)

This heart beat monitoring system using heart rate sensor(PIC) is designed to measure heart beat (pulse count), by using embedded technology. It can measure and monitor the patient’s condition. This describes the design of a simple, low-cost controller based wireless patient monitoring system. Heart rate of the patient is measured from the thumb finger using IRD (Infra-Red Device sensor. The heart rate can be measured by monitoring one's pulse using specialized medical devices such as an electrocardiograph (ECG), portable device. E.g. The patient heart beat monitoring systems is one of the major wrist strap watch, or any other commercial heart rate monitors which normally consisting of a chest strap with electrodes.
POTKONJAK Aleksandar and ŽEKIĆ STOŠIĆ Marina: Tick-borne infections of dogs in Serbia

Increased prevalence of tick-borne disease in humans and animals is an important public health issue. Dogs can be clinically ill, reservoirs of tick-borne pathogens, or sentinel populations for research. Certainly, small-scale research has been conducted in dogs and this review will focus on the recent studies of emergent and re-emergent tick-borne pathogens in dogs in Serbia. Babesiosis stands out as the most common and important tick-borne disease in dogs. In addition to this pathogen, the presence of Hepatozoon canis and “Candidatus Mycoplasma haematoparvum” in the blood of dogs was proved using molecular methods. Seroreactivity in dogs has been proven for Borrelia burgdorferi sensu lato (s.l.) complex, Ehrlichia canis, Ehrlichia ewingii, Anaplasma phagocytophilum, Anaplasma platys, Rickettsia conorii, and tick-borne encephalitis virus (TBEV). The presence of B. burgdorferi s.l. complex, A. phagocytophilum, Rickettsia spp. from the group of spotted fevers, and TBEV in ticks indicates the geographical distribution and potential for infecting humans, dogs, and other animals in Serbia. Further systematic, comprehensive, well designed, bacteriological, virological, parasitological, epidemiological, clinical (infectological), and acarological research is needed in Serbia.
CCID_A_224418 627..637

*These authors contributed equally to this work Purpose: The aim of the present study was to evaluate the potential wound healing activity of the hydroalcoholic extract of Salvia haenkei on in vitro and in vivo experimental models. Materials and Methods: Preliminary analytical characterization of the hydroalcoholic extract of Salvia haenkei was made by reversed-phase high performance liquid chromatography (RPHPLC) that permitted identification of a qualitative fingerprint of the extract of aerial parts. The wound healing activity of the hydroalcoholic extract of Salvia haenkei was evaluated in vitro by the scratch assay on human dermal fibroblasts and human epidermal keratinocytes and in vivo by standardized mouse excisional splinting model. Real-time PCR (RT-PCR) experiments were performed to analyze gene expression levels of inflammatory markers. Results: The scratch assay tests showed that the treatment with the hydroalcoholic extract of Salvia haenkei did not induce an increase in the fibroblasts migration rate with respect to the positive control. Instead, the hydroalcoholic extract of Salvia haenkei was effective in improving the wound closure rate on keratinocyte cell cultures with an almost total invasion of the scratch after 48 h of treatment; whereas the positive control, at the same time point, showed only a 67% reduction of the wound size. In vivo experiments showed that the groups treated with the extract of Salvia haenkei completely re-epithelized the wound in 2.7 days, a timing that was comparable with the action of the positive control that took only 2.1 days. Gene expression analysis showed that Salvia haenkei positively regulated the signaling pathway of the nuclear factor-κB (NF-κB) transcription factor. Conclusion: The results suggested that the hydroalcoholic extract of Salvia haenkei induced a clear wound healing effect.
The 8-Crystallin Enhancer-Binding Protein 6EF1 Is a Repressor of E2-Box-Mediated Gene Activation

The repressor 8EF1 was discovered by its action on the DC5 fragment of the lens-specific 81-crystallin enhancer. C-proximal zinc fingers of 8EF1 were found responsible for binding to the DC5 fragment and had specificity to CACCT as revealed by selection of high-affinity binding sequences from a random oligonucleotide pool. CACCT is present not only in DC5 but also in the E2 box (CACCTG) elements which are the binding sites of various basic helix-loop-helix activators and also the target of an unidentified repressor, raising the possibility that 8EF1 accounts for the E2 box repressor activity. 8EF1 competed with E47 for binding to an E2 box sequence in vitro. In lymphoid cells, endogenous 8EF1 activity as a repressor was detectable, and exogenous 8EF1 repressed immunoglobulin K enhancer by binding to the KE2 site. Moreover, bEF1 repressed MyoD-dependent activation of the muscle creatine kinase enhancer and MyoD-induced myogenesis of 1OT1/2 cells. Thus, 8lEF1 counteracts basic helix-loop-helix
Two-dimensional scattering of a Gaussian beam by a homogeneous gyrotropic circular cylinder

Two-dimensional scattering of a Gaussian beam by a homogeneous gyrotropic circular cylinder is presented. The incident Gaussian beam source is expanded as an approximate expression with Taylor's series. The transmitted field in the homogeneous gyrotropic cylinder is expressed in terms of the series of wave functions based on the integral equation. The unknown coefficients of the scattered fields are obtained with the aid of the boundary conditions of continuous tangential electric and magnetic fields. Some numerical results are presented and discussed. The result is in agreement with that available as expected when the Gaussian beam degenerates to a plane wave incidence case.
0.058 mm2 13 Gbit/s inductorless analogue equaliser with low-frequency equalisation compensating 15 dB channel loss

An inductorless 13 Gbit/s analogue equaliser with an additional low-frequency equalisation (LFEQ) to counter the low-frequency channel losses is presented. An active feedback topology for the proposed equaliser together with negative capacitance circuit is used to extend the bandwidth to compensate a 15 dB channel loss at Nyquist. The LFEQ improves the measured data jitter of the conventional equaliser from 0.41 to 0.12 UI, for a pseudorandom binary sequence of 2 31 - 1. The proposed prototype was implemented in 65 nm CMOS, occupying active area of merely 0.058 mm 2 . It exhibits a power efficiency of 1.07 mW/Gitb/s under a supply voltage of 1.2 V and a BER <; 10 -12 .
AENDO April 41/4

Ren, Song, Shalini Shatadal, and Garry X. Shen. Protein kinase C-b mediates lipoprotein-induced generation of PAI-1 from vascular endothelial cells. Am J Physiol Endocrinol Metab 278: E656–E662, 2000. —Elevated levels of low-density lipoproteins (LDL) and lipoprotein(a) [Lp(a)] have been considered strong risk factors for atherosclerotic cardiovascular disease. Increased production of plasminogen activator inhibitor-1 (PAI-1) has been implicated in the development of thrombosis and atherosclerosis. Previous studies by our group and others demonstrated that oxidation enhances LDLand Lp(a)-induced production of PAI-1 in human umbilical vein endothelial cells (HUVEC). The present study examined the involvement of protein kinase C (PKC) and its isoform in vascular endothelial cells (EC) induced by native or oxidized LDL and Lp(a). Treatment with Lp(a) or LDL transiently increased PKC activity at 15 min and 5.5 h after the start of lipoprotein treatment in EC. Copper-oxidized LDL and Lp(a) induced greater PKC activation in EC compared with comparable forms of those lipoproteins. Additions of 1 μM calphostin C, a PKC-specific inhibitor, at the beginning or $5 h, but not $9 h, after the initiation of lipoprotein treatment, blocked native and oxidized LDLor Lp(a)-induced increases in PKC activity and PAI-1 production. Treatment of LDL, Lp(a), or their oxidized forms was induced in translocation of PKC-b1 from cytosol to membrane in HUVEC. Treatments with 60 nM 379196, a PKC-b-specific inhibitor, effectively prevented PAI-1 production induced by LDL, Lp(a), or their oxidized forms in HUVEC and human coronary artery EC. The results suggest that activation of PKC-b may mediate the production of PAI-1 in cultured arterial and venous EC induced by LDL, Lp(a), or their oxidized forms.
Water stress tolerance in beans cv. Pinto Saltillo modified with the vacuolar pyrophosphatase-1 gene of Arabidopsis thaliana

The Arabidopsis Vacuolar Pyrophosphatase-1 (avp1) gene, which encodes the enzyme H+ pyrophosphatase, improves drought and salinity tolerance and increases biomass and yield when overexpressed in transgenic plants. The purpose of this study was to analyze the phenological, physiological and agronomic characteristics of beans cv. Pinto Saltillo (PS) transformed with the 35Sprom:avp1 gene under conditions of extreme water stress. The experimental design consisted of a random distribution of 10 homozygous plants for each of the 9 PS-avp1 lines, as well as unmodified control plants. Irrigation was suspended in the phenological stage of 50% flowering and water stress started from 100% to 9% volumetric water content (CVA), over 10 days. The results showed that the drought intensity index (IIS) was 0.78. Even though the stomatal conductance and perspiration showed a rate of decrease similar to the non-transformed plants, the photosynthetic rate of all PS-avp1 lines was higher than the control plants under conditions of water stress. The increase in total biomass in some PS-avp1 lines did not correlate with a higher yield. Seven of the nine lines evaluated showed a higher yield (35%-96%) compared to non-transformed PS plants under stress conditions, indicating greater efficiency in the translocation of photoassimilates to the target organs (seeds).
A High-Integration On-Chip Reconfigurable Monopole

In this paper, a silicon-based high-integration frequency reconfigurable monopole is designed. This antenna is designed on silicon wafer, and all manufacturing steps are completely compatible with silicon process. This method can integrate silicon-based antenna into communication system easily. To further improve the antenna’s integration, an optimized band stop filter is introduced into the antenna system to replace the conventional capacitor and inductor, and measurement results confirm the usefulness of this filter. Based on these results, the designed monopole achieved two frequency configurations at 3.23 GHz and 4.48 GHz, and other radiation parameters are also shown good results. key words: frequency reconfigurable monopole, high integration, band stop filter Classification: Microwave and millimeter wave devices, circuits, and hardware
A constructive approach for the design of finite time self-synchronizing coupled systems with unknown inputs

In this paper, we are interested in the problem of synchronization of coupled dynamical systems. The coupling under consideration is unidirectional and corresponds to a drive-response configuration. The drive system is supposed to be subjected to unknown inputs. It is provided a systematic methodology for selecting suitable driv e variables and for designing an appropriate response system so that a finite time self-synchronizing is achieved. The approach is based on the notion of flatness, a notion borrowed from control theory.
Fitting and forecasting coupled dark energy in the non-linear regime

We consider cosmological models in which dark matter feels a fifth force mediated by the dark energy scalar field, also known as coupled dark energy. Our interest resides in estimating forecasts for future surveys like Euclid when we take into account non-linear effects, relying on new fitting functions that reproduce the non-linear matter power spectrum obtained from N-body simulations. We obtain fitting functions for models in which the dark matter-dark energy coupling is constant. Their validity is demonstrated for all available simulations in the redshift range 0z=–1.6 and wave modes below 0k=1 h/Mpc. These fitting formulas can be used to test the predictions of the model in the non-linear regime without the need for additional computing-intensive N-body simulations. We then use these fitting functions to perform forecasts on the constraining power that future galaxy-redshift surveys like Euclid will have on the coupling parameter, using the Fisher matrix method for galaxy clustering (GC) and weak lensing (WL). We find that by using information in the non-linear power spectrum, and combining the GC and WL probes, we can constrain the dark matter-dark energy coupling constant squared, β2, with precision smaller than 4% and all other cosmological parameters better than 1%, which is a considerable improvement of more than an order of magnitude compared to corresponding linear power spectrum forecasts with the same survey specifications.