Miracle-dz/UniFAR-FTUs huggingface dataset:
Breaking down the entire W boson spin observables from its decay

We discuss the eight independent spin observables for the $W$ boson in terms of its vector and tensor polarizations and identify the angular distributions and asymmetries able to separate them in collider experiments. The results are applied to the study of polarized top quark decays and diboson resonances. These novel observables are of great value for disentangling new physics mechanisms in $W$ boson production.
Targeting CAM-DR and Mitochondrial Transfer for the Treatment of Multiple Myeloma

The prognosis of patients with multiple myeloma (MM) has improved dramatically with the introduction of new therapeutic drugs, but the disease eventually becomes drug-resistant, following an intractable and incurable course. A myeloma niche (MM niche) develops in the bone marrow microenvironment and plays an important role in the drug resistance mechanism of MM. In particular, adhesion between MM cells and bone marrow stromal cells mediated by adhesion molecules induces cell adhesion-mediated drug resistance (CAM-DR). Analyses of the role of mitochondria in cancer cells, including MM cells, has revealed that the mechanism leading to drug resistance involves exchange of mitochondria between cells (mitochondrial transfer) via tunneling nanotubes (TNTs) within the MM niche. Here, we describe the discovery of these drug resistance mechanisms and the identification of promising therapeutic agents primarily targeting CAM-DR, mitochondrial transfer, and TNTs.
Metabolites produced by inoculated Vigna radiata during bacterial assisted phytoremediation of Pb, Ni and Cr polluted soil

Phytoremediation assisted with plant growth promoting bacteria (PGPB) is a green technology to remediate metal contaminated soils. Plants usually produce secondary metabolites to tolerate metal toxicity. Present study was designed to explore the phytoremediation potential of Vigna radiata var. NM-II in the presence of metal resistant PGPB and comparison of metabolites produced under heavy metal stresses (Pb, Ni, Cr). Three PGPB selected for present study include Bacillus pumilus MB246, Serratia nematodiphila MB307 and Delftia Lacustris MB322. Pot experiments were conducted with inoculated V. radiata NM-II seeds grown in soil artificially contaminated with lead (Pb), Nickle (Ni) and chromium (Cr) at a concentration of 300, 200 and 100 mg/kg respectively. After harvesting various growth parameters were studied (root length, shoot length, fresh weight and dry weight). Bacterial colonization on root surfaces of harvested plants was observed through Scanning electron microscopy (SEM) and Elemental composition was recorded through Energy dispersive X-ray spectroscopy (EDX) attached with SEM. Metabolic response of harvested plants was studied through Gas chromatography Mass spectrophotometry (GC-MS) analysis. Metal accumulation in roots, shoots and soil was analysed by acid digestion method from which Bioaccumulation factor (BF) and Translocation factor (TF) of metal from soil to plant was calculated. Results revealed stimulatory effect of PGPB on growth and phytoextraction ability of V. radiata. Soil metal removal efficiency was in the order Pb>Ni>Cr, whereas metal distribution in each part of plant was root>stem>leaf. The BF and TF values suggested V. radiata as Pb and Ni excluder while moderate accumulator for Cr. Elemental analysis through Energy Dispersive X- ray spectroscopy (EDX) found potassium (K+)and calcium (Ca+)as highly abundant nutrients with least accumulation of sulphur (S). Metabolites study through GC-MS revealed variety of compounds (carbohydrates, amino acids, fatty acids, steroids etc) detected differentially under each metal treatment and their concentration was influenced by different bacterial inoculations. Overall 9-Octadecenamide was found as commonly present lipid compound in most of the treatments which is required for detoxification in plants. The study concluded beneficial role of PGPB for successful phytoremediation of heavy metals and differential response of metabolites towards each metal stress that is related to metal tolerance ability of V. radiata.
Integrable couplings of a generalized D-Kaup-Newell soliton hierarchy and their Hamiltonian structures

We present an enlarged spectral problem starting from a generalization of the D-Kaup-Newell (D-KN) spectral problem. Then we solve the enlarged zerocurvature equations to produce a series of Lax pairs and corresponding evolution equations formulating the desired integrable couplings. A reduction is made of the original enlarged spectral problem and the related zero-curvature equations are solved generating a second integrable coupling system. Next, we discuss how to compute bilinear forms that are symmetric, ad-invariant, and non-degenerate on the given non-semisimple matrix Lie algebra to employ the variational identity. The variational identity is applied to the original enlarged spectral problem of a generalized D-KN hierarchy to furnish Hamiltonian structures. Then we apply the variational identity to the reduced problem to see its bi-Hamiltonian structures. Both hierarchies have infinitely many commuting symmetries and conserved densities, i.e., are Liouville integrable.
Spectroscopic characterization of 78 DENIS ultracool dwarf candidates in the solar neighborhood and the Upper Scorpii OB association

Aims. We search for new ultracool dwarfs and report here our observations of 78 ultracool dwarf candidates that have been photometrically selected using the DENIS survey point source catalogue. We analyze low-resolution optical spectroscopic observations to estimate spectral types of all candidates. Methods. We derive spectral types for each object using measurements of the PC3 spectral index as defined in Martin et al. They range from M6 to L3. The Hα emission and NaI subordinate doublet (818.3 nm and 819.9 nm) equivalent widths are measured in the spectra to identify young stellar objects. Spectroscopic indices of TiO, VO, CrH, and FeH molecular features are also reported. Results. A rule-of-thumb criterion for selecting young very low-mass objects using the NaI doublet equivalent width is given. It is used to confirm seven new members of the Upper Sco OB association and two new members of the R Cr-A star-forming region. Four of our field objects are also classified as very young, but are not members of any known nearby young association. The frequency of lower-gravity young objects in our field ultracool sample is 8.5%. Our results provide the first spectroscopic classification for 42 ultracool dwarfs in the solar vicinity with spectrophotometric distances in the range 17 pc to 65 pc (3 of them being new L dwarfs within 20 pc).
May the Force (Field) Be with You: On the Importance of Conformational Searches in the Prediction of NMR Chemical Shifts

NMR data prediction is increasingly important in structure elucidation. The impact of force field selection was assessed, along with geometry and energy cutoffs. Based on the conclusions, we propose a new approach named mix-J-DP4, which provides a remarkable increase in the confidence level of complex stereochemical assignments—100% in our molecular test set—with a very modest increment in computational cost.
Cascaded cold atomic ensembles in a diamond configuration as a spectrally entangled multiphoton source

We theoretically investigate the spectral entanglement of a multiphoton source generated from the cascade emissions in the cascaded cold atomic ensembles. This photon source is highly directional, guaranteed under the four-wave mixing condition, and is also highly frequency-correlated due to finite driving pulse durations and superradiant decay constants. We utilize Schmidt decomposition to study the bipartite entanglement of the biphoton states projected from the multiphoton ones. This entropy of entanglement can be manipulated by controlling the driving parameters and superradiant decay rates. Moreover the projected biphoton states in the cascaded scheme can have larger entanglement than the one produced from only one atomic ensemble, which results from larger capacity in multipartite entanglement. This cascaded scheme enables a multiphoton source useful in quantum information processing. It also allows for potential applications in multimode quantum communication and spectral shaping of high-dimensional continuous frequency entanglement.
Mapping the Milky Way bulge at high resolution: the 3D dust extinction, CO, and X factor maps

Three dimensional interstellar extinction maps provide a powerful tool for stellar population analysis. We use data from the VISTA Variables in the Via Lactea survey together with the Besan\c{c}on stellar population synthesis model of the Galaxy to determine interstellar extinction as a function of distance in the Galactic bulge covering $ -10 < l < 10$ and $-10 < b <5$. We adopted a recently developed method to calculate the colour excess. First we constructed the H-Ks vs. Ks and J-Ks vs. Ks colour-magnitude diagrams based on the VVV catalogues that matched 2MASS. Then, based on the temperature-colour relation for M giants and the distance-colour relations, we derived the extinction as a function of distance. The observed colours were shifted to match the intrinsic colours in the Besan\c{c}on model as a function of distance iteratively. This created an extinction map with three dimensions: two spatial and one distance dimension along each line of sight towards the bulge. We present a 3D extinction map that covers the whole VVV area with a resolution of 6' x 6', using distance bins of 0.5 kpc. The high resolution and depth of the photometry allows us to derive extinction maps for a range of distances up to 10 kpc and up to 30 magnitudes of extinction in $A_{V}$. Integrated maps show the same dust features and consistent values as other 2D maps. We discuss the spatial distribution of dust features in the line of sight, which suggests that there is much material in front of the Galactic bar, specifically between 5-7 kpc. We compare our dust extinction map with high-resolution $\rm ^{12}CO$ maps towards the Galactic bulge, where we find a good correlation between $\rm ^{12}CO$ and $\rm A_{V}$. We determine the X factor by combining the CO map and our dust extinction map. Our derived average value is consistent with the canonical value of the Milky Way.
Quantum uncertainty based on metric adjusted skew information

Prompted by the open questions in Gibilisco [P. Gibilisco, Fisher information and means: Some questions in the classical and quantum settings, Int. J. Software Informatics 8 (2014) 265–276], he introduced a family of measurement-induced quantum uncertainty measures via metric adjusted skew informations, we investigate these measures’ fundamental properties (including basis independence and spectral representation), and illustrate their applications to detect quantum nonlocality and entanglement.
How the diffuse Universe cools

In this work we investigate the cooling channels of diffuse gas (i.e. n_H<0.1 cm^-3) in cosmology. We aim to identify the wavelengths where most of the energy is radiated in the form of emission lines or continuum radiation, and the main elements and ions responsible for the emission. We use a subset of cosmological, hydrodynamical runs from the OWLS project to calculate the emission of diffuse gas and its evolution with time. We find that at z=0 (z=2) about 70 (80) per cent of the energy emitted by diffuse gas is carried by emission lines, with the continuum radiation contributing the remainder. Hydrogen lines in the Lyman series are the primary contributors to the line emission, with a share of 16 (20) per cent. Oxygen lines are the main metal contributors at high redshift, while silicon, carbon and iron lines are strongest at low redshift, when the contributions of AGB stars and supernova Ia explosions to the metal budget become important and when there is more hot gas. The ionic species carrying the most energy are OIII, CII, CIII, SiII, SiIII, FeII and SIII. The great majority of energy is emitted in the UV band (lambda=100-4000 A), both as continuum radiation and line emission. With almost no exception, all the strongest lines fall in this band. At high energies, continuum radiation is dominant (e.g., 80 per cent in the X-ray band), while lines contribute progressively more at lower energies. While the results do depend on the details of the numerical implementation of the physical processes modelled in the simulations, the comparison of results from different simulations demonstrates that the variations are overall small, and that the conclusions are fairly robust. Given the overwhelming importance of UV emission for the cooling of diffuse gas, it is desirable to build instruments dedicated to the detection and characterisation of diffuse UV emission.
The Evolution of Binaries in a Gaseous Medium: Three-dimensional Simulations of Binary Bondi–Hoyle–Lyttleton Accretion

Binary stars are common. While only those with small separations may exchange gas with one another, even the widest binaries interact with their gaseous surroundings. Drag forces and accretion rates dictate how these systems are transformed by these interactions. We perform three-dimensional hydrodynamic simulations of Bondi–Hoyle–Lyttleton flows, in which a binary moves supersonically relative to a homogeneous medium, using the adaptive mesh refinement code FLASH. We simulate a range of values of the initial semimajor axis of the orbit relative to the gravitational focusing impact parameter of the pair. When the binary separation is less than the gravitational focusing impact parameter, the pair orbits within a shared bow shock. When the pair is wider, each object has an individual bow shock structure. The long-term evolution of the binary is determined by the timescales for accretion, slowing of the center of mass, and orbital inspiraling. We find a clear hierarchy of these timescales; a binary’s center-of-mass motion is slowed over a shorter timescale than the pair inspirals or accretes. In contrast to previous analytic predictions, which assume an unperturbed background medium, we find that the timescale for orbital inspiraling is proportional to the semimajor axis to the 0.19 ± 0.01 power. This positive scaling indicates that gaseous drag forces can drive binaries either to coalescence or to the critical separation at which gravitational radiation dominates their further evolution. We discuss the implications of our results for binaries embedded in the interstellar medium, active galactic nuclei disks, and common envelope phases.
Frenkel-like Wannier-Mott excitons in few-layer Pb I 2

Optical measurements and first-principles calculations of the band structure and exciton states in direct-gap bulk and few-layer $\mathrm{Pb}{\mathrm{I}}_{2}$ indicate that the $n\phantom{\rule{0.16em}{0ex}}=\phantom{\rule{0.16em}{0ex}}1$ exciton is Frenkel-like in nature in that its energy exhibits a weak dependence on thickness down to atomic-length scales. Results reveal large increases in the gap and exciton binding energy with a decreasing number of layers and a transition of the fundamental gap, which becomes indirect for one and two monolayers. Calculated values are in reasonable agreement with a particle-in-a-box model relying on the Wannier-Mott theory of exciton formation. General arguments and existing data suggest that the Frenkel-like character of the lowest exciton is a universal feature of wide-gap layered semiconductors whose effective masses and dielectric constants give bulk Bohr radii that are on the order of the layer spacing.
Hamstring muscle architecture assessed sonographically using wide field of view: A reliability study

Purpose To assess the intra-rater reliability of static wide field of view ultrasound to quantify the architectural characteristics of the hamstring muscles. Methods Twenty amateur male athletes were recruited. Their left hamstring muscles were assessed using static wide field of view ultrasound on two separate occasions. Static ultrasound images were acquired by a single sonographer using a 92mm linear transducer. The architectural characteristics (muscle length, fascicle length, pennation angle and muscle thickness) from two distinct locations of the bicep femoris long head and semimembranosus were evaluated. Muscle length and thickness of the bicep femoris short head and semitendinosus muscle were also evaluated. Intraclass correlation coefficient analyses were performed to determine the intra-rater reliability of the performed measurements. Results Both muscle (intraclass correlation coefficient = 0.99; standard error of measurement = 4.3 to 6.6mm) and fascicle (intraclass correlation coefficient = 0.92 to 0.98; standard error measurement = 1.1 to 2.4mm) length were measured with excellent intra-rater reliability. Muscle thickness was measured with excellent reliability (intraclass correlation coefficient = 0.9 to 0.96; standard error of measurement = 0.91mm to 1.4mm) for all hamstring muscles except for the proximal segments of the bicep femoris short head (intraclass correlation coefficient = 0.85; standard error of measurement = 0.84mm) and semitendinosus (intraclass correlation coefficient = 0.88; standard error of measurement = 0.82mm), which were measured with good reliability. Pennation angle was measured with good reliability (intraclass correlation coefficient = 0.77 to 0.87; standard error of measurement = 1 to 1.6°). Conclusion The architectural characteristics of the hamstring muscles of male amateur athletes can be reliably quantified using static wide field of view ultrasound.
Slow light in saturable absorbers : Progress in the resolution of a controversy

There are two opposing models in the analysis of the slow transmission of light pulses through saturable absorbers. The canonical incoherent bleaching model simply explains the slow transmission by combined effects of saturation and of non-instantaneous response of the medium resulting in absorption of the front part of the incident pulse larger than that of its rear. The second model, referred to as the coherent-population-oscillations (CPO) model, considers light beams whose intensity is slightly pulse modulated and attributes the time delay of the transmitted pulse to a reduction of the group velocity. We point out some inconsistencies in the CPO model and show that the two models lie in reality on the same hypotheses, the equations derived in the duly rectified CPO model being local expressions of the integral equations obtained in the incoherent bleaching model. For large modulation index, the CPO model, based on linearized equations, breaks down. The incoherent bleaching model then predicts that the transmitted light should vanish when the intensity of the incident light is strictly zero. This point is confirmed by the experiments that we have performed on ruby with square-wave incident pulses and we show that the whole shape of the observed pulses agrees with that derived analytically by means of the incoherent bleaching model. We also determine in this model the corresponding evolution of the fluorescence light, which seems to have been evidenced in other experiments.
Transcriptomics of acute myeloid leukaemia core bone marrow biopsies reveals distinct therapy response‐specific osteo‐mesenchymal profiles

While the bone marrow (BM) microenvironment is significantly remodelled in acute myeloid leukaemia (AML), molecular insight into AML‐specific alterations in the microenvironment has been historically limited by the analysis of liquid marrow aspirates rather than core biopsies that contain solid‐phase BM stroma. We assessed the effect of anthracycline‐ and cytarabine‐based induction chemotherapy on both haematopoietic and non‐haematopoietic cells directly in core BM biopsies using RNA‐seq and histological analysis. We compared matched human core BM biopsies at diagnosis and 2 weeks after cytarabine‐ and anthracycline‐based induction therapy in responders (<5% blasts present after treatment) and non‐responders (≥5% blasts present after treatment). Our data indicated enrichment in vimentin (VIM), platelet‐derived growth factor receptor beta (PDGFRB) and Snail family transcriptional repressor 2 (SNAI2) transcripts in responders, consistent with the reactivation of the mesenchymal population in the BM stroma. Enrichment of osteoblast maturation‐related transcripts of biglycan (BGN), osteopontin (SPP1) and osteonectin (SPARC) was observed in non‐responders. To the best of our knowledge, this is the first report demonstrating distinct osteogenic and mesenchymal transcriptome profiles specific to AML response to induction chemotherapy assessed directly in core BM biopsies. Detailing treatment response‐specific alterations in the BM stroma may inform optimised therapeutic strategies for AML.
Amelia and phocomelia in Finland: Characteristics and prevalences in a nationwide population‐based study

Amelia and phocomelia represent severe limb reduction defects. Specific epidemiologic data on these defects are scarce. We conducted a descriptive analysis of prevalence data in Finland during 1993–2008 to clarify the epidemiology nationwide in a population‐based register study. We hypothesized that increasing maternal age would affect the total prevalence of each disorder.
The Effect of Intraocular Pressure Load Boundary on the Biomechanics of the Human Conventional Aqueous Outflow Pathway

Background: Aqueous humor outflow resistance in the trabecular meshwork (TM), juxtacanalicular connective tissue (JCT), and Schlemm’s canal (SC) endothelium of the conventional outflow pathway actively contribute to intraocular pressure (IOP) regulation. Outflow resistance is actively affected by the dynamic outflow pressure gradient across the TM, JCT, and SC inner wall tissues. The resistance effect implies the presence of a fluid–structure interaction (FSI) coupling between the outflow tissues and the aqueous humor. However, the biomechanical interactions between viscoelastic outflow tissues and aqueous humor dynamics are largely unknown. Methods: A 3D microstructural finite element (FE) model of a healthy human eye TM/JCT/SC complex was constructed with elastic and viscoelastic material properties for the bulk extracellular matrix and embedded elastic cable elements. The FE models were subjected to both idealized and a physiologic IOP load boundary using the FSI method. Results: The elastic material model for both the idealized and physiologic IOP load boundary at equal IOPs showed similar stresses and strains in the outflow tissues as well as pressure in the aqueous humor. However, outflow tissues with viscoelastic material properties were sensitive to the IOP load rate, resulting in different mechanical and hydrodynamic responses in the tissues and aqueous humor. Conclusions: Transient IOP fluctuations may cause a relatively large IOP difference of ~20 mmHg in a very short time frame of ~0.1 s, resulting in a rate stiffening in the outflow tissues. Rate stiffening reduces strains and causes a rate-dependent pressure gradient across the outflow tissues. Thus, the results suggest it is necessary to use a viscoelastic material model in outflow tissues that includes the important role of IOP load rate.