Miracle-dz/UniFAR-FTUs huggingface dataset:
Pliocene climate , processes and problems

Introduction. Pliocene climate, processes and problems BY ALAN M. HAYWOOD*, HARRY J. DOWSETT, PAUL J. VALDES, DANIEL J. LUNT, JANE E. FRANCIS AND BRUCE W. SELLWOOD School of Earth and Environment, University of Leeds, Leeds LS2 9JT, UK US Geological Survey, 926A National Center, Reston, VA 20192, USA School of Geographical Sciences, University of Bristol, University Road, Bristol BS8 1SS, UK Postgraduate Research Institute for Sedimentology (PRIS ), University of Reading, Whiteknights, Reading RG6 6AB, UK
A 2.14 ms candidate optical pulsar in SN1987A: Ten years after

We have monitored Supernova 1987A in optical/near-infrared bands from a few weeks following its birth until the present time in order to search for a pulsar remnant. We have found an apparent pattern of emission near the frequency of 467.5 Hz - a 2.14 ms pulsar candidate, first detected in data taken on the remnant at the Las Campanas Observatory (LCO) 2.5-m Dupont telescope during 14-16 Feb. 1992 UT. We detected further signals near the 2.14 ms period on numerous occasions over the next four years in data taken with a variety of telescopes, data systems and detectors, at a number of ground- and space-based observatories. The sequence of detections of this signal from Feb. `92 through August `93, prior to its apparent subsequent fading, is highly improbable (< 10{sup -10} for any noise source). We also find evidence for modulation of the 2.14 ms period with a {approx}1,000 s period which, when taken with the high spindown of the source (2-3 x 10{sup -10} Hz/s), is consistent with precession and spindown via gravitational radiation of a neutron star with a non- axisymmetric oblateness of {approx}10{sup -6}, and an implied gravitational luminosity exceeding that of the Crab Nebula pulsar by an order of magnitude.
ANCE AND RECENT TRENDS: A COMPARATIVE ANALYSIS

The aim of this study is twofold.1 The first is an empirical evaluation and comparison of Poland’s economic transformation from 1990–2012 against the results achieved in the same period by Hungary, the Czech Republic, the Slovak Republic and Ukraine. The second aim is to assess the economic performance of these five countries during the severe test of the 2008–2009 global financial crisis. The study focuses on major economic aspects of the market transformation. Consequently, the empirical analyses center on the initial macroeconomic stabilization frameworks and then on the general growth mechanisms because they are embedded in the standard descriptive growth model.
PREVALENCE AND ANTIBIOGRAM OF PLESIOMONAS SHIGELLOIDES ISOLATED FROM HUMANS AND SOME ENVIRONMENTAL SOURCES

Plesiomonas shigelloides are gram negative bacteria, implicated for numerous gastrointestinal infections such as diarrhoea. They are ubiquitous and have been successfully isolated from human as well as environmental samples. The rise in antibiotic resistance coupled with the increasing role of P. shigelloides in human diseases have made a study of the antibiogram of P. shigelloides important. The present study sought to isolate P. shigelloides from human and environmental samples and perform antibiogram profiling of the isolates. Thirty nine (39) P. shigelloides isolates from human and environmental (water, soil and seafood) samples collected in Port Harcourt were studied using standard microbiological procedures. P. shigelloides was isolated in 5(1.67%) of 300 patients, 24(15.0%) of 160 well-water samples, 8(16.0%) of 50 soil samples and 2(4.0%) of 50 seafood samples with significance difference (p <0.05) in the various sources. In human samples, the susceptibility pattern of P. shigelloides was in the order Nitrofurantoin, Nalidixic acid, Colistin sulphate and Tetracycline (100%) > Cotrimoxazole (80%)>Sulphonamide (60%)> Ampicillin (20%)> Streptomycin (0%). Seafood isolates had a susceptibility pattern in a decreasing order; Nalidixic acid, Nitrofurantoin and Tetracycline (100%) > Ampicillin, Co-trimoxazole and Streptomycin (50%) > Streptomycin (0.00%). Soil isolates had a susceptibility pattern in the order; Nalidixic acid and Nitrofurantoin (100%)>Co-trimoxazole and Tetracycline (75%)> Sulphonamide (50%)>Ampicillin and Streptomycin (0.00%). Well-water and soil samples demonstrated a decreasing trend of resistance in the order Nitrofurantoin and Nalidixic acid (100%) > Tetracycline (45.83%)>Colistin-sulphate (41.67%) > Co-trimoxazole (37.5%) > Sulphonamide (29.17%) > Ampicillin (4.17%)>Streptomycin (0.00%). The present study highlight Nalidixic acid and Nitrofurantoin as drugs of choice for treating Plesiomonas infections as they recorded 100 % sensitivity to all isolates studied. Outright resistance was reported against ampicillin in soil samples, with all other antimicrobials recording varying degrees of sensitivity. None of the isolates were susceptible to streptomycin. Overall, human isolates were more sensitive to studied antibiotics compared to the environmental samples. This could be due to various factors leading to antibiotic resistance in the environment. There is a great need for improved environmental practices, precisely proper waste management could reduce incidents of antibiotic resistance.
MicroRNA ‐ 124 ‐ 5 p delays the progression of cerebral aneurysm by regulating FoxO 1

Cerebral aneurysm (CA) is a common brain disease, and the development of cerebral aneurysm is driven by inflammation and hemodynamic stress. MicroRNA (miR)‐124‐5p is reported to be associated with inflammatory response in brain disease such as cerebral ischemia‐reperfusion injury. However, the function and molecular mechanism of miR‐124‐5p in CA are not clear, thus, the effects of miR‐124‐5p on inflammatory response in CA were explored. Firstly, the expression of miR‐124‐5p in the peripheral blood of patients with CA and the control group was detected by reverse transcription‐quantitative PCR. Then, the human umbilical vein endothelial cells (HUVECs) were used as an in vitro model system and stimulated with interleukin (IL)‐1β to simulate the inflammatory environment of CA, and the expression of miR‐124‐5p was detected. Next, the effect of miR‐124‐5p on the migration and invasion of HUVECs was detected using Transwell assays. Meanwhile, the function of miR‐124‐5p on various inflammatory factors was determined by western blotting and enzyme‐linked immunosorbent assay (ELISA). Next, the TargetScan website was used to predict FoxO1 as a target gene of miR‐124‐5p, and this target association was validated by double luciferase reporter assay and western blotting. Finally, the interaction of miR‐124‐5p with FoxO1 in CA was measured by Transwell western blot‐ ting and ELISA assays. The results showed that the expression level of miR‐124‐5p in the peripheral blood of patients with CA was lower compared with that of control group, and the miR‐124‐5p in HUVECs stimulated by IL‐1β was less compared with that in normal HUVECs. Besides, miR‐124‐5p could inhibit the migration and invasion abilities of HUVECs and the release of inflammatory factors. Additionally, the overexpression of miR‐124‐5p was able to inhibit the expression of FoxO1. miR‐124‐5p‐inhibitor promoted the migration and invasion of HUVECs, as well as inflammatory response, which was weakened following the introduction of FoxO1 small interfering RNA. Overall, the present study demonstrated that miR‐124‐5p could prevent the occurrence and development of cerebral aneurysm by downregulating the expression of FoxO1.
Cluster Ensemble Approach for Semi Supervised Clustering

: The semi-supervised clustering are important extensions of the standard clustering paradigm. Consensus clustering (also known as aggregation of clustering) can improve clustering robustness, deal with distributed and heterogeneous data sources and make use of multiple clustering criteria. Semi-supervised clustering can integrate various forms of background knowledge into clustering. In this paper, we show how consensus and semi-supervised clustering can be formulated within the framework of nonnegative matrix factorization (NMF). We show that this framework yields NMF-based algorithms that are: (1) extremely simple to implement; (2) provably correct and provably convergent. We conduct a wide range of comparative experiments that demonstrate the effectiveness of this NMF-based approach.Clustering ensemble is one of the most recent advances in unsupervised learning. It aims to combine the clustering results obtained using different algorithms or from different runs of the same clustering algorithm for the same data set, this is accomplished using on a consensus function, the efficiency and accuracy of this method has been proven in many works in literature. The semi-supervised clustering algorithms used to generate the base partitions; the second parameter is used to provide the user feedback on these partitions. The two parameters are engaged in a “relabeling and voting” based consensus function to produce the final clustering.
Does Overuse or Genetics Play a Greater Role in Determining Subacromial Space Width?

Galley Page 1 of 14 AUTHOR: Note that your paper has been extensively copyedited according to Journal style. Please carefully review the entire galley (and not just the highlighted edits and author queries) to make sure that all information (including text and any tables, figures, references, and appendices) is correct as presented, as I had to make a number of inferences regarding your meaning. Please make any changes directly on the galley. NIH: TK Article type: Scientific Articles Collection: Shoulder Disclosure: None of the authors received payments or services, either directly or indirectly (i.e., via his or her institution), from a third party in support of any aspect of this work. None of the authors, or their institution(s), have had any financial relationship, in the thirty-six months prior to submission of this work, with any entity in the biomedical arena that could be perceived to influence or have the potential to influence what is written in this work. Also, no author has had any other relationships, or has engaged in any other activities, that could be perceived to influence or have the potential to influence what is written in this work. The complete Disclosures of Potential Conflicts of Interest submitted by authors are always provided with the online version of the article. Peer review: This article was reviewed by the Editor-in-Chief and one Deputy Editor, and it underwent blinded review by two or more outside experts. The Deputy Editor reviewed each revision of the article, and it underwent a final review by the Editor-inChief prior to publication. Final corrections and clarifications occurred during one or more exchanges between the author(s) and copyeditors.
PPA_A_259095 1185..1193

Pia Kirkegaard 1 Line Winther Gustafson 1,2 Lone Kjeld Petersen 3,4 Berit Andersen 1,2 1Department of Public Health Programmes, Randers Regional Hospital, Randers, Denmark; 2Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 3Open Patient Data Explorative Network (OPEN), Department of Clinical Medicine, University of Southern Denmark, Odense, Denmark; 4Department of Gynaecology and Obstetrics, Odense University Hospital, Odense, Denmark Background: The incidence of cervical cancer peaks around the age of 75 years, and elderly patients are more frequently diagnosed with advanced-stage cervical cancer than younger patients. There is considerable practice variation regarding follow-up of elderly patients with abnormal cervical test results at risk of cervical cancer, both nationally and internationally, due to uncertainty about risks and benefits for this particular patient group. The treatment preferences of these patients are, however, poorly described in the current literature. The aim of this study was to explore elderly patients’ experiences with abnormal cervical test results and preferences for follow-up. Materials and Methods: We performed focus group interviews with seventeen Danish patients aged 60–79 years who had undergone biopsy and colposcopy in gynaecological outpatient clinics or at private gynaecologists due to a positive human papillomavirus (HPV) test result and/or abnormal cytology. A focus group interview guide was designed to cover experiences with abnormal cervical test results, including realistic risk and benefit scenarios related to underdiagnosis and overtreatment. Data were analysed thematically using a phenomenological approach. Results: The patients were surprised that elderly could also have an HPV infection. Most preferred treatment and follow-up at the gynaecologist over continuous control visits at the general practitioner. In case of persistent HPV infection and cervical intraepithelial neoplasia, a quick solution including cone biopsy was preferred even if it carried a risk of overtreatment. The patients wanted clear recommendations and demonstrated considerable intolerance towards healthcare professionals’ clinical uncertainty regarding optimum follow-up. Conclusion: Most elderly patients wanted closure involving cone biopsy, and they expressed tolerance towards overtreatment to reduce their risk of cervical cancer. Thus, clinicians should present known risks and benefits to elderly patients facing risk of overtreatment after abnormal cervical test results.
Effects of Moisture Content and Temperature on the Dielectric Strength of Transformer Insulating Oil

Article history: Received 2 October 2019 Received in revised form 23 October 2019 Accepted 30 October 2019 Available online 18 November 2019 The primary function of insulating oils is to dissipate heat and provide electrical insulation for turn-to-turn windings in power transformers. These oils also serve as a means to monitor the health status of power transformers. At present, most transformer failures are due to the presence of moisture as well as heat, oxidation, and electrical stresses. The main objective of this research was to study the effects of moisture content and temperature on the dielectric strength of transformer insulating oil, which is known be the factors that lead to transformer failures. The effect of moisture content was investigated by varying the amount of distilled water added into the insulating oil samples from 1 mL to 5 mL with 1-mL increments. The effect of temperature was investigated by increasing the oil temperature from 40°C to 120°C with 20°C increments. The dielectric strength of each insulating oil sample was assessed by performing AC breakdown voltage tests according to the MS IEC 60156:2012 standard. With the assistance of FTIR spectra revealed that the chemical compounds of transformer insulating oil were also affected (based on absorption band) due to the presence of moisture and temperature. Based on the results, it can be concluded that moisture and temperature have a significant effect on the dielectric strength and chemical compounds of transformer insulating oil.
SECURITY ENHANCEMENT USING NEURAL NETWORKS FOR DATA TRANSMISSION

— Cryptography is a process of protecting information and data from unauthorized access. The goal of any cryptographic system is the access of information among the intended user without any leakage of information. As technology advances the methods of traditional cryptography becomes more and more complex. Neural Networks provide an alternate way for crafting a security system whose complexity is far less than that of the current cryptographic systems and has been proven to be productive. Both the communicating neural networks receive an identical input vector, generate an output bit and are based on the output bit. Our approach is based on the application of natural noise sources that we can use to teach our system to approximate with the aim of generating an output non-linear function. This approach provides the potential for generating an unlimited number of unique Pseudo Random Number Generator (PRNG) that can be used on a one to one basis. We can use the PRNG generated to encrypt the input data and create a cipher text that has a high cryptographic strength.
REM AND NREM SLEEP CONTRIBUTIONS IN MEMORY FOR VERBAL MATERIAL

1875 Scrima’s Hypothesis Revisited—Deliens et al INTRODUCTION A positive contribution of post-learning sleep in the consolidation of new information in long-term memory is now widely recognized.1-7 Beneficial effects of post-learning sleep have been highlighted for various memory systems, such as verbal declarative memory,8,9 emotional memory,10,11 or spatial learning,12 and non-declarative motor procedural learning13 or priming.14 Like long-term memory, sleep is not a unitary process but comprises different subsystems.15,16 In humans, it is characterized by two prominent stages, rapid eye movement (REM) and non-rapid eye movement (NREM) sleep. NREM is further subdivided17 into stage 1 (N1), stage 2 (N2) and slow wave sleep (SWS or N3). Sleep stages, like memory subsystems, are differentiable at neuroanatomical, neurophysiological, and behavioral levels.3,18 Notwithstanding, how sleep stages specifically contribute to the consolidation of different memory types remains a matter of debate. REM AND NREM SLEEP CONTRIBUTIONS IN MEMORY FOR VERBAL MATERIAL
Specification of neuron identity requires the activation of a number of discrete developmental programs. Among these is pathway selection by growth cones: in order for a neuron’s growth cone to respond appropriately to guidance

The development of the nervous system requires the generation of basic neuronal cell types (neurogenesis) and the subsequent specification of a wide variety of unique neuron identities. Individual neurons must express the proper spectrum of neurotransmitters, the correct molecules required for transduction of synaptic stimuli, and direct appropriate axon pathfinding and synaptic specificity. Genes that regulate neurogenesis and nervous system patterning have been identified and studied in some detail (reviewed by Tanabe and Jessell, 1996), but relatively little is known about the specification of discrete neuronal cell types (Lewin, 1994). A complete understanding of neuron development demands knowledge of the mechanisms by which the unique properties of individual neurons are specified. One important aspect of neuron identity is selection of axon pathways. Growth cones navigate to their targets using molecular cues presented on cell and axon surfaces and the extracellular matrix (reviewed by Culotti, 1994; TessierLavigne and Goodman, 1996). The appropriate response to these cues presumes expression of the appropriate receptors on the growth cone. For example, ectopic expression of the putative netrin receptor UNC-5 causes growth cones to make inappropriate pathfinding decisions (Hamelin et al., 1993). Thus, expression of the correct receptors for axon pathfinding is a significant aspect of a particular neuron’s identity. The specification of neuron identities is thought to be mediated, at least in part, by transcription factors that modulate the expression of effector genes that function directly in specifying axon pathways and other aspects of neuron identity (reviewed by Daston and Koester, 1996; Goulding, 1998). Considerable attention has been focused on the LIM homeodomain transcription factors of both vertebrates and invertebrates. Examples of LIM proteins that have been shown to play significant roles in specifying particular pathways for growth cones include the Isl1, Isl2, Lim1, Lim3 and Lhx4 genes of vertebrates (Tsuchida et al., 1994; Sharma et al., 1998) and the islet, apterous, mec-3 and lin-11 genes of invertebrates (Way and Chalfie, 1988; Lundgren et al., 1995; Hobert et al., 1998; Thor et al., 1999). We are studying the mechanisms by which neurons select axon pathways in C. elegans, and have identified six genes that are required for pathfinding of growth cones along the ventral nerve cord (VNC; Wightman et al., 1997). Among these genes is fax-1, named for its defective fasciculation of axons phenotype. In fax-1 mutants, the growth cones of the AVKR, HSNL and PVQL neurons fail to follow their normal pathway. Because these growth cones all depend on the pre-existing PVPR axon (Garriga et al., 1993), fax-1 appears to be required 703 Development 127, 703-712 (2000) Printed in Great Britain © The Company of Biologists Limited 2000 DEV9674
CCDC7 Activates Interleukin-6 and Vascular Endothelial Growth Factor to Promote Proliferation via the JAK-STAT3 Pathway in Cervical Cancer Cells OncoTargets and Therapy

Objective: Tumor growth is one of the most lethal attributes of human malignancy. The expression of CCDC7, a novel gene which has multiple functions, has been shown to be associated with tumor growth and poor prognosis in patients with cancer. However, the speci ﬁ c functions of CCDC7 remain unclear. Here, we investigated the molecular mechanisms underlying the effects of CCDC7 on proliferation in cervical cancer. Materials and Methods: The MTT and EdU assays were performed to evaluate the function of CCDC7. The immunohistochemical, quantitative real-time PCR (qRT-PCR), ELISA and Western blot assay were used to detect the gene and protein expression in tissues and cells. A xenograft test was conducted to detect the impact of CCDC7 on tumor development in vivo . Results: In immunohistochemical analysis of 193 cases, normal cervical tissue and cervical cancer tissue show that CCDC7 expression is closely correlated with the development of cervical cancer and was positively correlated with the clinical stage and histological grade. Overexpression or knockdown of CCDC7 affected cell proliferation in cervical cancer cells in vitro. In a nude mouse xenograft model in vivo, knockdown of CCDC7 inhibited cell proliferation and tumor growth. Furthermore, CCDC7 overexpression upregulated interleukin (IL)-6 and vascular endothelial growth factor (VEGF) at mRNA and protein levels, and treatment with recombinant IL-6 or VEGF proteins also increased CCDC7 expression. In a case set of 80 patients with cervical cancer, we found that CCDC7, IL-6, and VEGF affected patient prognosis. Finally, inhibition of various signaling pathways using speci ﬁ c inhibitors indicated that CCDC7 blocked the decrease in cell proliferation observed following suppression of the JAK-STAT3 pathway, suggesting that CCDC7 functioned via this critical signaling network. Conclusion: Those ﬁ ndings indicated that CCDC7 may be a novel target for the treatment of cervical cancer and may have applications as a predictive marker for tumor growth in cervical carcinoma.
Comparison of Respiratory Strength of Eutrophic Individuals and People with Obesity Class II

Introduction: The excess of adipose tissue present in the obese individuals, can cause alteration in the respiratory functions and thus, the respiratory muscles have been characterized as insufficient. Objective: To evaluate the respiratory force in sedentary individuals with class II obesity and eutrophic individuals, comparing the values obtained in the groups and discussing results of greater discrepancy. Methods: We evaluated 87 sedentary individuals, being 45 individuals classified as having class II obesity and 42 eutrophic individuals. To compare the mean values of maximum respiratory pressures obtained and predicted values using the equations proposed by Costa. , et al. the manovacuometer was used, and also the Student’s t test with significance level p < 0.05. for the association between these values, the Spearman correlation coefficient was used. Results: The results measured for respiratory pressures in patients with class II obesity, measured in cmH2O was MIP 80.1 and MEP 58.2 ± 22; while for the eutrophic group the MIP was 77.4 ± 28.2 and MEP 108.6 ± 20.2. Conclusion: The data obtained indicated that patients with class II obesity presented statistically higher values of MIP (p = 0.005), but the MEP values were lower than those obtained by eutrophic ones and also in the predicted values, being able to be justified by the accumulation of fat in the abdominal region, consequently affecting the function of the expiratory muscles. The results obtained with the eutrophic volunteers pointed out that the sedentary lifestyle can be very harmful, influencing more than the weight gain for the respiratory pressures.