Miracle-dz/UniFAR-FTUs huggingface dataset:
New Insights into Chikungunya Virus Infection and Pathogenesis.

Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus responsible for major outbreaks of disease since 2004 in the Indian Ocean islands, South east Asia, and the Americas. CHIKV causes debilitating musculoskeletal disorders in humans that are characterized by fever, rash, polyarthralgia, and myalgia. The disease is often self-limiting and nonlethal; however, some patients experience atypical or severe clinical manifestations, as well as a chronic rheumatic syndrome. Unfortunately, no efficient antivirals against CHIKV infection are available so far, highlighting the importance of deepening our knowledge of CHIKV host cell interactions and viral replication strategies. In this review, we discuss recent breakthroughs in the molecular mechanisms that regulate CHIKV infection and lay down the foundations to understand viral pathogenesis. We describe the role of the recently identified host factors co-opted by the virus for infection and pathogenesis, and emphasize the importance of CHIKV nonstructural proteins in both replication complex assembly and host immune response evasion. Expected final online publication date for the Annual Review of Virology, Volume 8 is September 2021. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Purposed Built ZnO/Zn5(OH)8Ac2·2H2O Architectures by Hydrothermal Synthesis

Novel and extended ZnO/Zn5(OH)8Ac2·2H2O architectures are desirable for many applications. Here we report on the design and growth of the novel ZnO/Zn5(OH)8Ac2·2H2O architectures by a hydrothermal synthesis approach. ZnO microrods and/or columnar film are grown in the aqueous solution containing Zn(Ac)2·2H2O and hexamethylenetetramine, while Zn5(OH)8Ac2·2H2O microspheres and/or porous film are formed when enough citrate anions are added into the solution. The citrate anions not only modify the morphology but also decide the phase of the grown zinc compounds. The ZnO thin layer coated on glass substrate is used to control the nucleation event and finally modifies the morphology of the grown ZnO. Our work provides an effective and facile approach to design and selectively grow the novel ZnO/Zn5(OH)8Ac2·2H2O architectures at a low temperature of 95 °C.
Digital resilience mediates healthy use of technology

Excessive use of online technology brings with it the risk of problematic digital behaviour like over-use of social media, online gambling, webinar fatigue, digital burnout, and in extreme cases doom surfing, and doom scrolling. In addition, digital failures can cause significant mental health distress to people, and unhealthy interactions on social media can also lead to deviant behaviour such as cyber bullying and cybercrime. This paper discusses the various vulnerabilities an individual is predisposed to on the internet, and highlights the importance of “Digital Resilience”. Digital resilience is a new concept which refers to the learning, recovery, and bouncing back process after having negative or adverse experiences online. A comprehensive and holistic model to introduce Digital Resilience to everyone through a multitier approach that includes Individual, Societal, and Community intervention is formulated and elaborated. The importance of addressing these concerns from both a psychological and legal perspective is also discussed.
What defines quality of care for older people in aged care? A comprehensive literature review

The quality of the care provided to frail older people in aged care is a concern for all Australians and for the citizens of many other countries internationally. This paper summarizes the methods and findings from an Australian study commissioned by the Royal Commission into Aged Care Quality and Safety to identify and synthesize international literature relating to the quality of care in aged care. A comprehensive literature review was undertaken to search and identify the literature (grey and peer reviewed) relating to quality of care and/or person‐centered care in aged care. The review identified nine key themes as salient to the quality of care experience, which include treating the older person with respect and dignity; acknowledging and supporting their spiritual, cultural, religious and sexual identity; the skills and training of the aged care staff providing care; relationships between the older person and the aged care staff; social relationships and the community; supporting the older person to make informed choices; supporting the older person's health and well‐being; ensuring the delivery of safe care in a comfortable service environment; and the ability to make complaints and provide feedback to the aged care organization. In practice, particularly in the context of residential care, quality of care has traditionally been measured using clinical indicators of care quality. These findings highlight the central importance of person‐centered care and care experience as fundamental tenets of the quality of aged care service delivery in Australia and internationally. Geriatr Gerontol Int 2021; 21: 765–778.
Prolonged incubation period of hepatitis B in a recipient of a nucleic acid amplification test‐negative hepatitis B virus window donation

The occurrence of transfusion‐transmitted hepatitis B virus (HBV) infection has fallen dramatically due to continuous improvements in pre‐transfusion laboratory testing. However, the characteristics of transfusion‐transmitted HBV infection caused by individual donor nucleic acid amplification test (ID‐NAT)‐negative blood products are unclear.
Prolonged Grief and Bereavement Supports Within a Caregiver Population Who Transition Through a Palliative Care Program in British Columbia, Canada

Objective: To determine the prevalence of prolonged grief disorder (PGD), and self-reported resilience among bereaved caregivers within a palliative care program that serves a large region of the Lower Mainland in British Columbia, Canada. Additionally, to discern effective bereavement supports utilized by caregivers following the loss of a loved one. Methods: A descriptive study using both quantitative and qualitative methods. Sociodemographic information (n = 427) was collected from bereaved caregivers 3 months after their loss. PGD and resilience were prospectively assessed 12 months post-loss using the prolonged grief scale (PG-13, n = 212) and brief resilience scale (BRS, n = 215), respectively. A qualitative thematic analysis was conducted on responses to the open-ended question on what bereavement services or activities caregivers found helpful in coping with the loss of a loved one. Results: Of the 212 individuals that completed the PG-13, 4.7% met diagnostic criteria for PGD, 27.4% were moderate risk, and 67.9% were low risk for PGD. Of the 215 caregivers that completed the BRS, 48.4% had low resilience, 51.6% had normal resilience, and 0% had high resilience. The major themes of formal supports, informal supports, and self-care activities emerged from caregiver comments regarding effective bereavement supports. Conclusion: The incidence of PGD in caregivers is low within the Fraser Health Palliative Care program. Bereaved caregivers mainly utilize existing social networks and activities to cope with their loss. Focusing on a community-based approach to supports may improve bereavement experiences and lower rates of prolonged grief.
The Athlete and Gut Microbiome: Short-chain Fatty Acids as Potential Ergogenic Aids for Exercise and Training

Abstract Short-chain fatty acids (SCFAs) are metabolites produced in the gut via microbial fermentation of dietary fibers referred to as microbiota-accessible carbohydrates (MACs). Acetate, propionate, and butyrate have been observed to regulate host dietary nutrient metabolism, energy balance, and local and systemic immune functions. In vitro and in vivo experiments have shown links between the presence of bacteria-derived SCFAs and host health through the blunting of inflammatory processes, as well as purported protection from the development of illness associated with respiratory infections. This bank of evidence suggests that SCFAs could be beneficial to enhance the athlete’s immunity, as well as act to improve exercise recovery via anti-inflammatory activity and to provide additional energy substrates for exercise performance. However, the mechanistic basis and applied evidence for these relationships in humans have yet to be fully established. In this narrative review, we explore the existing knowledge of SCFA synthesis and the functional importance of the gut microbiome composition to induce SCFA production. Further, changes in gut microbiota associated with exercise and various dietary MACs are described. Finally, we provide suggestions for future research and practical applications, including how these metabolites could be manipulated through dietary fiber intake to optimize immunity and energy metabolism.
tsRNAsearch: a pipeline for the identification of tRNA and ncRNA fragments from small RNA-sequencing data

MOTIVATION tRNAs were originally considered uni-functional RNA molecules involved in the delivery of amino acids to growing peptide chains on the ribosome. More recently, the liberation of tRNA fragments from tRNAs via specific enzyme cleavage has been characterized. Detection of tRNA fragments in sequencing data is difficult due to tRNA sequence redundancy and the short length of both tRNAs and their fragments. RESULTS Here we introduce tsRNAsearch, a Nextflow pipeline for the identification of differentially abundant tRNA fragments and other non-coding RNAs from small RNA-sequencing data. tsRNAsearch is intended for use when comparing two groups of datasets, such as control and treatment groups. tsRNAsearch comparatively searches for tRNAs and ncRNAs with irregular read distribution profiles (a proxy for RNA cleavage) using a combined score made up of four novel methods and a differential expression analysis, and reports the top ranked results in simple PDF and TEXT files. In this study, we used publicly available small RNA-seq data to replicate the identification of tsRNAs from chronic hepatitis-infected liver tissue data. In addition, we applied tsRNAsearch to pancreatic ductal adenocarcinoma (PDAC) and matched healthy pancreatic tissue small RNA-sequencing data. Our results support the identification of miR135b from the original study as a potential biomarker of PDAC and identify other potentially stronger miRNA biomarkers of PDAC. AVAILABILITY https://github.com/GiantSpaceRobot/tsRNAsearch. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
National cross-sectional survey of 1.14 million NHS staff SARS-CoV-2 serology tests: a comparison of NHS staff with regional community seroconversion rates

Objectives An initial report of findings from 1.14 million SARS CoV-2 serology tests in National Health Service (NHS) staff to compare NHS staff seroconversion with community seroconversion rates at a regional level. Design A national cross-sectional survey. Setting A SARS-CoV-2 antibody testing programme offered across all NHS Trusts. Participants 1.14 million NHS staff. Intervention SARS-CoV-2 antibody testing. Primary and secondary outcome measures SARS-CoV-2 antibody testing was used to estimate the seroprevalence of SARS-CoV-2 in NHS staff by region, compared with community seroprevalence as determined by the COVID-19 Infection Survey (Office for National Statistics). We also explored seroprevalence trends by regional COVID-19 activity, using regional death rates as a proxy for COVID-19 ‘activity’. Results 1 146 310 tests were undertaken on NHS staff between 26 May and 31 August 2020. 186 897 NHS tests were positive giving a seroconversion rate of 16.3% (95% CI 16.2% to 16.4%), in contrast to the national community seroconversion rate of 5.9% (95% CI 5.3% to 6.6%). There was significant geographical regional variation, which mirrored the trends seen in community prevalence rates. NHS staff were infected at a higher rate than the general population (OR 3.1, 95% CI 2.8 to 3.5). NHS seroconversion by regional death rate suggested a trend towards higher seroconversion rates in the areas with higher COVID-19 ‘activity’. Conclusions This is the first cross-sectional survey assessing the risk of COVID-19 disease in healthcare workers at a national level. It is the largest study of its kind. It suggests that NHS staff have a significantly higher rate of COVID-19 seroconversion compared with the general population in England, with regional variation across the country which matches the background population prevalence trends. There was also a trend towards higher seroconversion rates in areas which had experienced high COVID-19 clinical activity. This work has global significance in terms of the value of such a testing programme and contributing to the understanding of healthcare worker seroconversion at a national level.
Composition of the Inner Nuclear Layer in Human Retina

Purpose The purpose of this study was to measure the composition of the inner nuclear layer (INL) in the central and peripheral human retina as foundation data for interpreting INL function and dysfunction. Methods Six postmortem human donor retinas (male and female, aged 31–56 years) were sectioned along the temporal horizontal meridian. Sections were processed with immunofluorescent markers and imaged using high-resolution, multichannel fluorescence microscopy. The density of horizontal, bipolar, amacrine, and Müller cells was quantified between 1 and 12 mm eccentricity with appropriate adjustments for postreceptoral spatial displacements near the fovea. Results Cone bipolar cells dominate the INL a with density near 50,000 cells/mm2 at 1 mm eccentricity and integrated total ∼10 million cells up to 10 mm eccentricity. Outside central retina the spatial density of all cell populations falls but the neuronal makeup of the INL remains relatively constant: a decrease in the proportion of cone bipolar cells (from 52% at 1 mm to 37% at 10 mm) is balanced by an increasing proportion of rod bipolar cells (from 9% to 15%). The proportion of Müller cells near the fovea (17%) is lower than in the peripheral retina (27%). Conclusions Despite large changes in the absolute density of INL cell populations across the retina, their proportions remain relatively constant. These data may have relevance for interpreting diagnostic signals such as the electroretinogram and optical coherence tomogram.
Adoptive Transfer of Autologous Invariant Natural Killer T Cells as Immunotherapy for Advanced Hepatocellular Carcinoma: A Phase I Clinical Trial

Abstract Lessons Learned Administration of autologous invariant natural killer T (iNKT) cells was safe and well‐tolerated in patients with hepatocellular carcinoma (Barcelona Clinic Liver Cancer stage B/C). Expanded iNKT cells produced T‐helper 1–like responses with possible antitumor activity. No severe adverse events were observed in any of the enrolled patients, including one patient who received 1010 in vitro–expanded autologous iNKT cells as a single infusion. Background Invariant natural killer T cells co‐express T‐cell antigen receptor and natural killer (NK) cell receptors. Invariant natural killer T (iNKT) cells exhibit antitumor activity, but their numbers and functions are impaired in patients with hepatocellular carcinoma (HCC). The adoptive transfer of iNKT cells might treat advanced HCC. Methods This phase I study (NCT03175679) enrolled 10 patients with HCC (Barcelona Clinic Liver Cancer [BCLC] stage B/C) at Beijing YouAn Hospital (April 2017 to May 2018). iNKT cells isolated from peripheral blood mononuclear cells (PBMCs) were expanded and alpha‐galactosylceramide (α‐GalCer)–pulsed. Dosage escalated from 3 × 107 to 6 × 107 to 9 × 107 cells/m2 (3+3 design). An exploratory dose trial (1 × 1010 cells/m2) was conducted in one patient. Results Expanded iNKT cells produced greater quantities of T‐helper 1 (Th1) cytokines (e.g., interferon‐gamma, perforin, and granzyme B) but less interleukin‐4 than nonexpanded iNKT cells. Circulating numbers of iNKT cells and activated NK cells were increased after iNKT cell infusion. Most treatment‐related adverse events were grade 1–2, and three grade 3 adverse events were reported; all resolved without treatment. Four patients were progression‐free at 5.5, 6, 7, and 11 months after therapy, and one patient was alive and without tumor recurrence at the last follow‐up. Five patients died at 1.5 to 11 months after treatment. Conclusion Autologous iNKT cell treatment is safe and well‐tolerated. Expanded iNKT cells produce Th1‐like responses with possible antitumor activity. The antitumor effects of iNKT cell infusion in patients with advanced HCC merit further investigation.
Growth of Oak Seedlings with Specific Ectomycorrhizae in Urban Stress Environments

Eleven-month old container grown seedlings of pin oak {Quercus palustris) and sawtooth oak (Q. acutissima) were outplanted on an earth-filled, steeply graded highway interchange near Atlanta, Georgia. The pin oak seedlings had either Pisolithus tinctorius (Pt) ectomycorrhizae or natural ectomycorrhizae (controls). The sawtooth seedlings had either Pt, Thelephora terrestris (Tt), or natural (controls) ectomycorrhizae. At the end of two growing seasons, pin oak seedlings with Pt ectomycorrhizae were larger than control seedlings. Pt ectomycorrhizae also increased survival and growth of seedlings of sawtooth oak in comparison to seedlings with Tt or control ectomycorrhizae.
An Extensive Analysis of Human Gender Prophecy using Computer Vision

One of the most important demographic features of human beings is gender. One can easily distinguish between male and female human faces by looking at their images, but enabling computers to identify a person’s gender is a tough job. Human gender recognition with computer vision has found its relevance in a number of fields, ranging from day to day software applications to forensic science, particularly due to the certain surge in usage of social media and social networking websites. This paper, in particular, provides a review of human gender recognition in computer vision from still images and video recording datasets. A survey of different approaches using information ranging from faces to the full body (either from still images or video sequences) have been taken into account and carefully presented. Through this paper, we have reviewed the methods incorporated by various authors in their approaches. Various performances and accuracies have been achieved with the different approaches using different datasets under controlled and uncontrolled environments, though there is much more yet to be done on this topic.
Running Head: BAGDADI METHOD AND TAHFIZ STUDENTS’ INTRINSIC MOTIVATION International Conference on Language, Literature, Culture and Education

This study aims to explore the impact of the adoption of Bagdadi method on tahfiz students’ intrinsic motivation and their ability to master Qur’an recitation. To achieve the aim, the researcher purposively selected and interviewed a number of tahfiz teachers and students from Sekola Dar-Al Muhibbeen, Kuala Lumpur to examine how learning by Bagdadi method influence students’ intrinsic motivation. Besides that, non participant observations were conducted to ensure the trustworthiness of the data. The data were collected, transcribed, coded and separated, and then analyzed using inductive analysis model. The findings show that the use of Bagdadi intrinsically motivates tahfiz students to learn reading Qur’an; enable them to read Qur’an within one month especially those with good psychomotor skills and students perceive learning with Bagdadi is easy and funny as it gives them happiness and enjoyment in the classroom. Finally, this research helps tahfiz teachers in boosting up their interest to use Bagdadi in their teaching.
Feature Level Solution to Noise Robust Speech Recognition in the context of Tonal Languages

3864 Published By: Blue Eyes Intelligence Engineering & Sciences Publication Retrieval Number: B4513129219/2019©BEIESP DOI: 10.35940/ijeat.B4513. 129219  Abstract:Performance of a speech recognition system is highly dependent on the operational environments. The mismatched ambient conditions have adverse impact on the performance of an Automatic Speech Recognition (ASR) system. The speech parameterization techniques for tonal speech recognition are different from those used for non-tonal speech recognition. It is due to the fact that tonal speech has two components – basic linguistic unit and tone. The basic linguistic unit with different tones convey different meanings. Therefore, the feature set used for tonal speech recognition must have the capability to representing both of them. Tone is determined by the fundamental frequency of the speech signal which is highly sensitive to noise. Since at the time of parameterization of the non-tonal speech recognition systems, these highly noise-sensitive tone related information are discarded, the traditional noise elimination methods used for non-tonal speech recognition fail to deliver robust performance in tonal speech recognition. In the present study, we have analyze the performance of different commonly used feature sets for noisy tonal speech recognition. Hidden Markov Model (HMM) based speech recognizer has been used for performance evaluation. Noise elimination techniques sub-band spectral subtraction and Wiener filter have been used for noise reduction and their relative performance have been evaluated.
Measuring Traffic Safety Culture toward Achieving Road Safety Performance: A DEA Approach with Undesirable Inputs-Outputs

Abstract The main purpose of this paper is to propose a new purely data-driven method for measuring impact of road safety culture based only on the aggregated data on traffic safety indicators rather than on questionnaire surveys. The paper proposes the use of data envelopment analysis (DEA) with undesirable inputs-outputs for quantitative assessment of the impact on road fatalities of road safety culture. This method determines a number of road safety factors and then distinguishes between the effects of specified factors and the cultural factors. The applicability and usefulness of the proposed DEA are illustrated in a real-world application for assessment of the impact of road safety culture on Iran provincial road fatalities in the time period of two years. Results of DEA enable differentiating between provinces according to the impact of cultural aspects on fatality rate. Moreover, results show that road safety culture on average has improved in the time period of two years. The results of this study may be considered as a basis for traffic safety culture (TSC) interventions at provincial level. This paper provides a new opportunity to look at road safety culture across provincial road transportation systems in Iran and represents a critical step toward understanding relationship between safety culture and safety performance.
Foot landing patterns in experienced and novice volleyball players during spike jumps

Volleyball practice is known to require a large number of jumps. During landing, impact forces can reach up to 6 BW, and it was suggested that injuries may occur when these forces are not attenuated properly (Dufek & Bates, 1990). Appropriate foot landing patterns such as forefoot landings seem to reduce peak vertical ground reaction force (vGRF) compared to flatfoot landings during a single-leg drop jump (Teng et al., 2020). Furthermore, it has been shown that the landing pattern of recreational athletes was modified after expert feedback during a double-leg drop jump, suggesting that the expertise level may influence the foot landing pattern (Etnoyer et al., 2013). However, these controlled tasks did not fully reflect volleyball-specific jumps.