Miracle-dz/UniFAR-FTUs huggingface dataset:
Demographic profiles and environmental drivers of variation relate to individual breeding state in a long-lived trans-oceanic migratory seabird, the Manx shearwater

Understanding the points in a species breeding cycle when they are most vulnerable to environmental fluctuations is key to understanding interannual demography and guiding effective conservation and management. Seabirds represent one of the most threatened groups of birds in the world, and climate change and severe weather is a prominent and increasing threat to this group. We used a multi-state capture-recapture model to examine how the demographic rates of a long-lived trans-oceanic migrant seabird, the Manx shearwater Puffinus puffinus, are influenced by environmental conditions experienced at different stages of the annual breeding cycle and whether these relationships vary with an individual’s breeding state in the previous year (i.e., successful breeder, failed breeder and non-breeder). Our results imply that populations of Manx shearwaters are comprised of individuals with different demographic profiles, whereby more successful reproduction is associated with higher rates of survival and breeding propensity. However, we found that all birds experienced the same negative relationship between rates of survival and wind force during the breeding season, indicating a cost of reproduction (or central place constraint for non-breeders) during years with severe weather conditions. We also found that environmental effects differentially influence the breeding propensity of individuals in different breeding states. This suggests individual spatio-temporal variation in habitat use during the annual cycle, such that climate change could alter the frequency that individuals with different demographic profiles breed thereby driving a complex and less predictable population response. More broadly, our study highlights the importance of considering individual-level factors when examining population demography and predicting how species may respond to climate change.
A systematic review of self-report measures used in epidemiological studies to assess alcohol consumption among older adults

Background There is a lack of standardization regarding how to assess and categorize alcohol intake in older adults. The aim of this study was to systematically review methods used in epidemiological studies to define drinking patterns and measure alcohol consumption among older adults. Methods A systematic search was conducted in the MEDLINE, PubMed, PsycINFO, EMBASE, and CINAHL databases for studies published from January 2009 to April 2021. Studies were included if they were observational studies with a quantitative design; the mean age of the participants was ≥ 65 years; questionnaires, screening tools, or diagnostic tools were used to define alcohol consumption; and alcohol consumption was self-reported. Results Of 492 studies considered, 105 were included. Among the 105 studies, we detected 19 different drinking patterns, and each drinking pattern had a wide range of definitions. The drinking patterns abstaining from alcohol, current drinking, and risk drinking had seven, 12 and 21 diverse definitions, respectively. The most used questionnaire and screening tools were the quantity-frequency questionnaire, with a recall period of 12 months, and the full and short versions of the Alcohol Use Disorders Identification Test, respectively. Conclusion No consensus was found regarding methods used to assess, define, and measure alcohol consumption in older adults. Identical assessments and definitions must be developed to make valid comparisons of alcohol consumption in older adults. We recommend that alcohol surveys for older adults define the following drinking patterns: lifetime abstainers, former drinkers, current drinkers, risk drinking, and heavy episodic drinking. Standardized and valid definitions of risk drinking, and heavy episodic drinking should be developed. The expanded quantity-frequency questionnaire including three questions focused on drinking frequency, drinking volume, and heavy episodic drinking, with a recall period of 12 months, could be used.
Association between salt intake and long-term mortality in hemodialysis patients: A retrospective cohort study

Background The association between salt intake and clinical outcomes in hemodialysis patients has been controversial. This study aimed to clarify the association between salt intake and mortality in hemodialysis patients. Method The present study included patients who underwent hemodialysis from June 1st 2016 to May 31st 2020. Corrected salt intake by ideal body weight was the main predictor of outcomes. Ideal body weight was calculated assuming that the ideal body mass index is 22 kg/m2 for the Japanese population. The multivariate Cox proportional hazards model was used to determine the association between corrected salt intake and mortality, adjusting for potential confounders. The outcomes considered were all-cause mortality and cumulative incidence of cardiovascular events at year 4. Result A total of 492 adult patients were enrolled in the study. The mean daily salt intake and corrected salt intake at baseline were 9.5 g/day and 0.17 g/kg/day, respectively. The low corrected salt intake group (< 0.13 g/kg/day) demonstrated the highest 4-year all-cause mortality. No association was observed between corrected salt intake and the cumulative incidence of cardiovascular events. In multivariate Cox proportional hazards analysis, only the group with corrected salt intake of 0.16–0.20 g/kg/day was associated with a decreased hazard risk for all-cause death compared with the low corrected salt intake group. Conclusion The present study found that a low salt intake was associated with high all-cause mortality in hemodialysis patients. Reduced long-term survival may be attributed to malnutrition resulting from excessive salt restriction.
Proposals for project collection and classification from the analysis of the ISBSG Benchmark 8

This work presents statistical analysis scenarios of a sample of software development and enhancement projects contained in the Benchmark 8 by ISBSG (International Software Benchmarking Standards Group, 2003). The research – started in the second half of 2003 – is an on-going, incremental process based on the voluntary participation of the members of the SBC (Software Benchmarking Committee) of GUFPI-ISMA (Italian Software Metrics Association). This work is focused on the distribution of development and enhancement projects in the ISBSG sample with regard to: sizing method, project size, completion date, productivity, and primary programming language. Some considerations and hints arise from this research to improve the data collection process (by ISBSG as well as by any private organization within its own benchmarking database). Categorization criteria and taxonomies are identified and suggested for standardized use in order to clarify the definition and the comparison of future software projects.
Intelligent decision support system for the adaptive control of a flexible manufacturing system with machine and tool flexibility

This paper describes an intelligent decision support system (IDSS) for real time control of a flexible manufacturing system (FMS). The controller is capable of classifying symptoms in developing the control policies on FMSs with flexibility in operation assignment and scheduling of multi-purpose machining centres which have different tools with their own efficiency. The proposed system is implemented by coupling of rule-based IDSS, simulation block and centralised simulation optimiser for elicitation of shop floor control knowledge. This posteriori adaptive controller uses a new bilateral mechanism in simulation optimiser block for offline training of IDSS based on multi-performance criteria simulation optimisation. The proposed intelligent controller receives online information of the FMS current state and trigger appropriate control rule within real-time simulation data exchange. Finally the FMS intelligent controller is validated by a benchmark test problem. Application of this adaptive controller showed that it could be an effective approach for real time control of various flexible manufacturing systems.
Improved transmission scheme for reliable communication in cell boundary

In a wireless communication system, the performance of the system is degraded due to the attenuation of the signal by path loss when a user is distant from the base station. For improvement of the system in this case, a new scheme is proposed. In conventional schemes, the source can transmit to the destination belonging to own cell coverage. In the proposed scheme, the destination can receive the additional signal from another base station through multiple relays. Therefore, the proposed scheme provides higher diversity gain and better performance than the conventional scheme.
Influence of functional gene polymorphisms on human behaviour: the case of CCR5

The idea that genetic changes can impact behaviour and lead to novel therapeutic approaches for mental illness has been an attractive, yet elusive hypothesis. A couple of recent papers in JPN build the case for the effectiveness of maraviroc in ameliorating depression1 and reducing the addictive properties of opioids without preventing their analgesic effects.2 Maraviroc is an antagonist of C-C motif chemokine receptor-5 (CCR5) and has been shown prevent HIV infection by blocking its coreceptor CCR5. These new studies build on the finding that people with a 32-bp deletion mutation that inactivates CCR5 (CCR5-Δ32) and show resistance to HIV also have improved cognitive outcomes after a stroke.3 The studies also extend a growing literature implicating CCR5 in mental illness and suggest that further clinical studies using maraviroc as a novel treatment or adjuvant, particularly in patients with inflammatory depression involving immune dysregulation,4 may be warranted. These findings suggest genetic polymorphisms with a strong functional impact (e.g., loss of function) may provide insight into mechanisms underlying certain forms of mental illness and lead to new treatments. Much effort has been directed at studying genetic variants (such as polymorphisms) that can be used to identify risk of major depression or to improve its treatment. Improving diagnosis of depression may help overcome obstacles to treatment response. The first-line treatment for major depression remains the selective serotonin reuptake inhibit or (SSRI) class of antidepressants,5 even though these medications are effective in only 50% of patients, take several weeks to yield a response, and are associated with many adverse effects.6,7 Thus, alternative strategies, including augmentation or switching to alternative monoaminetargeting compounds, cognitive behavioural therapy (CBT) and various brain stimulation approaches, are indicated for patients with SSRI-resistant depression. Ultimately, about 30% of patients are treatment resistant,6 failing to respond to at least 3 treatments; most often electroconvulsive therapy or another form of brain stimulation is indicated, which may help half of these patients.8,9 Better alternatives are needed to treat major depression, and genetic approaches may reveal new drug targets that could be exploited for treatment-resistant depression.
Extending the stroke treatment window beyond DAWN in patients with very slow progressor type collaterals: How far can we go?

Five trials published in 2015 showed the benefit of endovascular thrombectomy (ET) in patients with stroke and large vessel occlusion, extending the treatment window has become an obsession of all physicians. In 2018, the DAWN and DEFUSE-3 trials showed that, with careful selection of patients, the procedure could be carried out up to 24 hours after symptom onset with good outcomes. In addition, there have been cases where the DAWN criteria were met, and treatment occurred >24 hours after symptom onset. We present the case of a 68-year-old female whose groin puncture occurred 52 hours after the time last known well (TLKW), after neurological worsening of the initial situation, with a large mismatch ratio observed on magnetic resonance imaging, achieving TICI (the Thrombolysis in Cerebral Infarction scale) grade 3 recanalization. Five days after the procedure, the patient was discharged with NIHSS (National Institutes of Health Stroke Scale) score of 3. Some types of collateral circulation (slow progressors and “turtle” progressors, our term for very slow progressors) can extend the treatment window beyond 24 hours of the TLKW but can lead to a hyperperfusion-like syndrome immediately after the ET. Further studies are needed to evaluate the reproducibility of this hypothetical syndrome.
IOT Big Data Process Based on Context Temporal-Spatial Characteristics in Petroleum Products Distribution

For solving problem of heterogeneity data process and low data processing capability in the Internet of Things (IOT), data in IOT is abstracted as “Context”; taking “Context” as the unified object in IOT big data process, a model of big data process based on Hadoop framework (HDC) is designed. Finally, apply the proposed model to solve problem of vehicle scheduling in petroleum products distribution, capacity of data process is validated by MapReduce distributed parallel computing experiments. Results of the experiments show that HDC has obvious excellence in big data process compared with ordinary computing system.
Blinatumomab Maintenance After Allogeneic Hematopoietic Cell Transplantation for B-lineage Acute Lymphoblastic Leukemia.

Patients with B-lineage acute lymphoblastic leukemia (ALL) are at high-risk for relapse after allogeneic hematopoietic cell transplantation (HCT). We conducted a single center phase II study evaluating the feasibility of 4 cycles of blinatumomab administered every 3 months during the first year after HCT in an effort to mitigate relapse in high-risk ALL patients. Twenty-one of 23 enrolled patients received at least one cycle of blinatumomab and were included in the analysis. The median time from HCT to the first cycle of blinatumomab was 78 days (range, 44-105). Twelve patients (57%) completed all 4 treatment cycles. Neutropenia was the only grade 4 adverse event (19%). Rates of cytokine release (5% G1) and neurotoxicity (5% G2) were minimal. The cumulative incidence of acute GVHD grades 2-4 and 3-4 were 33% and 5%, respectively; two cases of mild (10%) and one case of moderate (5%) chronic GVHD were noted. With a median follow-up of 14.3 months, the 1-year overall survival, progression-free survival, and non-relapse mortality rates were 85%, 71%, and 0%, respectively. In a matched-analysis with a contemporary cohort of 57 patients, we found no significant difference between groups regarding blinatumomab's efficacy. Correlative studies of baseline and post-treatment samples identified patients with specific T-cell profiles as "responders" or "non-responders" to therapy. Responders had higher proportions of effector memory CD8 T-cell subsets. Non-responders were T-cell deficient and expressed more inhibitory checkpoint molecules, including TIM3. We found that blinatumomab post-allogeneic HCT is feasible, and its benefit is dependent on the immune milieu at time of treatment.
Radiological risk assessment of natural radionuclides in the marine ecosystem of the northwest Mediterranean Sea

Abstract Purpose This study aimed to assess the radiological risk of natural radionuclides (226Ra, 232Th, and 40K) to marine ecosystem biota. Materials and methods The study site in this was the Mediterranean Sea, Cyprus. With the use of the RESRAD-BIOTA (RESidual RADioactivity BIOTA) code, the tissue concentration, external and internal dose rate of aquatic animals and riparian animals were estimated. Results The total tissue concentrations of the aquatic animals and riparian animals were simulated at 1.14 × 106 Bq/kg (water media) to 0 Bq/kg (sediment media), and 1.33 × 106 Bq/kg (water media) to 9.79 × 101 Bq/kg (sediment media), respectively. The total dose rate for aquatic animals and riparian animals was ranged from 1.94 × 10−2 to 0 Gray per day (Gy/d) and 1.46 × 10−2 to 7.40 × 10−7 Gy/d, respectively. Conclusions Based on the risk assessment of this study, there is no significant impact due to organisms' exposure to natural radioactivity. Although, further consideration of the exposure levels is required due to the potential effects of protracted low-level ionizing radiation.
Research Trends for Decision Aids for Change Management

This paper presents the analysis of two surveys, one academic and one industrial. The goal was to provide research perspectives in the field of change management for industrial systems. This communication is the result of multi-disciplinary study (ADESI project) launched by the National Centre of Scientific Research, CNRS. The "raison d'etre" of this work, is to answer the strong need to coordinate both academic and industrial communities as well as the necessity of multi-disciplinary approaches for decision-aids applied to change management.
Evidence for a kernel of truth in children's facial impressions of children's niceness, but not shyness.

Adults teach children not to "judge a book by its cover. " However, adults make rapid judgments of character from a glance at a child's face. These impressions can be modestly accurate, suggesting that adults may be sensitive to valid signals of character in children's faces. However, it is not clear whether such sensitivity requires decades of social experience, in line with the development of other face-processing abilities (e.g., facial emotion recognition), or whether this sensitivity emerges relatively early, in childhood. An important theoretical question therefore, is whether or not children's impressions are at all accurate. Here, we examined the accuracy in children's impressions of niceness and shyness from children's faces. Children (aged 7-12 years, ∼90% Caucasian) and adults rated 84 unfamiliar children's faces (aged 4-11 years, 48 female, ∼80% Caucasian) for niceness (Study 1) or shyness (Study 2). To measure accuracy, we correlated facial impressions with parental responses to well-established questionnaires about the actual niceness/shyness of those children in the images. Overall, children and adults formed highly similar niceness (r = .94) and shyness (r = .84) impressions. Children also showed mature impression accuracy: Children and adults formed modestly accurate niceness impressions, across different images of the same child's face. Neither children nor adults showed evidence for accurate shyness impressions. Together, these results suggest that children's impressions are relatively mature by middle childhood. Furthermore, these results demonstrate that any mechanisms driving accurate niceness impressions are in place by 7 years, and potentially before. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
International Perspectives on Spelling and Writing in Different Orthographies: Introduction to the Special Series

This article serves as an introduction to the special issue on spelling and writing in different orthographies. Most studies and theoretical models of writing are based on the English language, and it is generally assumed that what is true for English is also true for other languages. Further, there are more studies on reading compared to studies of writing and spelling. Considering that 80% of the world’s population speaks a language other than English, we need more studies on writing and spelling in languages other than English. With this intention, we are presenting 6 papers on writing and spelling in different languages of different orthographic depth, from highly transparent orthographies like Spanish and Italian to highly opaque orthography like Cantonese.
Goal-Based Binding of Irrelevant Stimulus Features for Action Slips

Abstract. Binding between representations of stimuli and actions and later retrieval of these compounds provide efficient shortcuts in action control. Recent observations indicate that these mechanisms are not only effective when action episodes go as planned, but they also seem to be at play when actions go awry. Moreover, the human cognitive system even corrects traces of error commission on the fly because it binds the intended but not actually executed response to concurrent task-relevant stimuli, thus enabling retrieval of a correct, but not actually executed response when encountering the stimulus again. However, a plausible alternative interpretation of this finding is that error commission triggers selective strengthening of the instructed stimulus–response mapping instead, thus promoting its efficient application in the future. The experiment presented here makes an unequivocal case for episodic binding and retrieval in erroneous action episodes by showing binding between task-irrelevant stimuli and correct responses.
On the go with SONOS

Advancements in scaling gate insulators for MOS transistors permit low-voltage, silicon-oxide-nitride-silicon (SONOS) nonvolatile semiconductor memories (NVSMs) for a wide range of applications. The continued scaling of SONOS devices offers improved performance with a small cell size, single-level polysilicon with low voltage, fast erase/write, improved memory retention, increased endurance, and radiation hardness. In this article, we discuss scaled SONOS devices, SONOS memory technology, and some SONOS NVSM applications.
Identification of glucocorticoid-related molecular signature by whole blood methylome analysis

Objective Cushing’s syndrome represents a state of excessive glucocorticoids related to glucocorticoid treatments or to endogenous hypercortisolism. Cushing’s syndrome is associated with high morbidity, with significant inter-individual variability. Likewise, adrenal insufficiency is a life-threatening condition of cortisol deprivation. Currently, hormone assays contribute to identify Cushing’s syndrome or adrenal insufficiency. However, no biomarker directly quantifies the biological glucocorticoid action. The aim of this study was to identify such markers. Design We evaluated whole blood DNA methylome in 94 samples obtained from patients with different glucocorticoid states (Cushing’s syndrome, eucortisolism, adrenal insufficiency). We used an independent cohort of 91 samples for validation. Methods Leukocyte DNA was obtained from whole blood samples. Methylome was determined using the Illumina methylation chip array (~850 000 CpG sites). Both unsupervised (principal component analysis) and supervised (Limma) methods were used to explore methylome profiles. A Lasso-penalized regression was used to select optimal discriminating features. Results Whole blood methylation profile was able to discriminate samples by their glucocorticoid status: glucocorticoid excess was associated with DNA hypomethylation, recovering within months after Cushing’s syndrome correction. In Cushing’s syndrome, an enrichment in hypomethylated CpG sites was observed in the region of FKBP5 gene locus. A methylation predictor of glucocorticoid excess was built on a training cohort and validated on two independent cohorts. Potential CpG sites associated with the risk for specific complications, such as glucocorticoid-related hypertension or osteoporosis, were identified, needing now to be confirmed on independent cohorts. Conclusions Whole blood DNA methylome is dynamically impacted by glucocorticoids. This biomarker could contribute to better assessment of glucocorticoid action beyond hormone assays.