Miracle-dz/UniFAR-FTUs huggingface dataset:
Determination of the efficacy of ultrasound-guided bilateral transversus abdominis plane (US-TAP) block in laparoscopic total extraperitoneal (TEP) repair of unilateral hernia surgeries: A randomized controlled trial

Background and Aims: Bilateral ultrasound-guided transversus abdominis plane (US-TAP) block has been successfully used to provide analgesia for most lower abdominal procedures. Our aim was to determine the efficacy of US-TAP block with levobupivacaine in laparoscopic total extraperitoneal (TEP) repair of unilateral hernia surgeries under general anaesthesia (GA) as compared to no block. Material and Methods: It is prospective randomised controlled study done in a tertiary care centre in South-East Asia. After obtaining Institute Ethics Committee approval and consent, 60 patients of ASA I-II aged between 18 to 80 years were randomized into two groups.After receiving GA, Group TAP - received bilateral US-TAP block with levobupivacaine 0.25% 0.3ml kg-1 on either side whereas, the control group did not receive any block.The time taken to first request for rescue analgesic (T Rescue) by the patient and the Numeric Rating Scale (NRS) at that time point were noted and tramadol 50mg i.v. was administered, followed by 50mg i.m. PRN for 24 h from the time of extubation. The 24 h analgesic requirement was noted in mg kg-1. Results: Results were analysed using SPSS 16 and P < 0.05 was considered significant. T Rescue was significantly longer in the TAP Group (P = 0.02) with lower NRS at time points 24 h (P = 0.02) and 12 h (P = 0.004). Postoperative nausea and vomiting were significantly less in TAP Group (P < 0.001). Conclusion: Bilateral US-TAP block provided better analgesia and side effect profile as compared to no block when administered in laparoscopic TEP repair of hernia surgeries.
Impact of early versus late tracheostomy on patient outcomes in a tertiary care multispeciality ICU

Background and Aims: Tracheostomy is a commonly performed procedure in critically ill patients because patients requiring chronic mechanical ventilation (MV) are rising by as much as 5.5% per year. The controversy on likely benefits of early versus late tracheostomy is ongoing. We aimed to study the impact of early versus late tracheostomy on patient outcomes. Material and Methods: A retrospective observational study was performed in intensive care unit (ICU) patients who underwent tracheostomy in a 31-bedded multispeciality ICU of a 350-bedded tertiary care hospital, over a period of 1 year. Data collected included the age, sex, APACHE II score, indication for tracheostomy, timing of procedure, whether surgical or percutaneous, any complication, MV days, ICU stay, and patient outcome. Patients were divided into two groups for statistical comparison: early ≤7 days and late >7 days of MV. Results: A total of 102 patients underwent tracheostomy over the study period, of which 19 were excluded because of inadequate data and exclusion criteria. Of the 83 study patients, 60 had percutaneous, while 23 had surgical tracheostomy. About 51 (61.45%) had early, while 32 (38.55%) had late tracheostomy. On statistical analysis, there was a significant difference in MV days (5 vs 12.5 days, P = 0.002), ICU stay (10 vs 16 days, P = 0.004), mortality (21.6% vs 43.8%, P = 0.032), and decannulation rate (29.41% vs 6.25%, P = 0.009). No difference was observed in hospital stay or complication rates. Conclusion: Early tracheostomy is associated with both morbidity and mortality benefits. Patients requiring MV should be given an option of early tracheostomy.
Giant Aortic Root Pseudoaneurysm Surrounding the Left Main Coronary Artery

A 69-year-old patient underwent an urgent aortic valve replacement because of Streptococcus agalactiae endocarditis of his native aortic valve. Since a rapid progression of the former abscess cavity into an aortic root pseudoaneurysm with increasing paravalvular regurgitation during postoperative follow-up, reoperation was performed. In the preoperative transesophageal echocardiography (TEE) images the pseudoaneurysm completely surrounds the left coronary artery (LCA) without any signs of myocardial ischemia.
Controllable preparation and high properties of fluorescence and surface enhanced raman spectra encoded poly(glycidyl methacrylate) microsphere

Novel fluorescence and SERS encoded microspheres based on poly(glycidyl methacrylate) (PGMA) microspheres were developed by a controllable approach. The microspheres were encoded by four fluorescence dyes and three surface enhanced Raman spectra (SERS) probes. Multiple dyes could be simultaneously incorporated into the PGMA microspheres for encoding and the intensity of the fluorescence can be tuned by adjusting the feeding ratio. The PGMA microspheres were coated by silver nanoparticles and encoded by single and multiple SERS reporters. The fluorescence and SERS joint encoded PGMA microspheres were fabricated. All the fluorescence encoding signals can be excited at 488 nm. The fluorescent and SERS signals of dual-mode microspheres could be obtained from two optical channels and non-overlapping of emission spectra was observed in these encoded microspheres, which greatly increased the encoding capacity. The as prepared fluorescence and SERS encoded microspheres possess stable and distinct spectral encoding signals, large encoding capacity.
OP-JHPS180049 410..424

Femoral version is reported to vary in relation to age, gender and other patient-specific factors. Differences in femoral version are suspected to contribute to the development of hip pathology. However, normative data on pathologic hips has never been reported. To evaluate the femoral version in a large population of patients with symptomatic hip pathology treated with arthroscopy and report differences within this group based on age, gender, bony morphology and other hip-related factors. A prospectively gathered database of 1449 hips was reviewed. All patients underwent pre-operative MRI with measure of femoral version. The average femoral version of the entire population was 8. 4þ 9.2 , range 23 to 63. There no statistically significant differences encountered based on age, gender, bony morphology or other hip-related factors. Across all groups, there was wide variation in the femoral version present. Among younger patients, there was trend to have a greater proportion of retroversion. Significant variation in femoral version exists in patients with symptomatic hip pathology. Although the geometry of the proximal femur is commonly described as anteverted, relative retroversion is also frequently encountered. I N T R O D U C T I O N The natural history of femoral anteversion is that infants are born with high femoral anteversion that decreases with age. Typically at birth, femoral anteversion is 40 and decreases to 16 by skeletal maturity [1]. There are observed population differences based on gender, with females having greater anteversion than males [2,3]. Other series suggest that additional variation exist based on ethnicity [4, 5]. Femoral version is a relevant measurement that affects hip range of motion and pathology. Significantly increased femoral anteversion affects the rotational profile of the lower extremity, leading to increased internal rotation. Retroversion of the femur may cause anterior femoroacetabular impingement. In one study, patients with decreased femoral version had worse outcomes after hip arthroscopy [6]. Other series have shown equivalent outcomes [7, 8]. The purpose of our study is to evaluate the femoral version in a large group of patients with hip conditions treated with arthroscopy. This group of symptomatic patients may differ from previously reported normative data. Further variation in femoral version may be observed within subgroups of our patient population, based on factors such as age, gender and bony morphology. Defining expected variation may provide better understanding of the pathoanatomy of the hip that leads to symptoms.
OP-HEAL180044 15..26

This study assessed attitudes toward HIV and awareness of previous HIV prevention campaigns among young black men in the United States of America (USA). The study also ascertained the appropriateness of HIV testing messages for young black men and explored the use of social networking sites to deliver HIV testing messages for social media marketing campaigns. Nineteen (n1⁄4 19) black male college students attending a public university in Atlanta, GA, USA from September 2016 to October 2016 participated in three focus groups. The focus groups consisted of a group interview querying experiences with HIV and STI testing, awareness of HIV campaigns, solicited feedback on campaign messages and the use of social networking sites to deliver messages. Data analysis involved the grounded theory approach to identify emergent themes. Fear, stigma and low risk perception were discussed as barriers to HIV testing. HIV prevention, social support and new sexual partners were discussed as reasons for testing. There was a general lack of awareness of existing HIV testing campaigns. Messaging with a universal appeal and disseminated through Twitter, Instagram and Snapchat may counter narratives of fear, stigma and low risk perception to increase HIV testing among young black men. Introduction HIV has been a public health issue in the United States (US) for well over 30 years and continues to affect various subpopulations throughout the country, including young black men. Young black gay and bisexual men (aged 13–24 years) account for the largest number of HIV diagnoses [1, 2]. Furthermore, among heterosexual men (those who only have sex with women, MSW), blacks account for the highest number of new HIV diagnoses compared with their counterparts in other racial/ethnic groups [3]. The high rates of new infections among young black men can be attributed to infrequent HIV testing and late diagnoses among this population in addition to never testing for HIV [4, 5]. HIV testing remains a key prevention measure especially when considering that young black men report incorrect and inconsistent condom use [6–11] and men who have sex with men (MSM) report low awareness of pre-exposure prophylaxis (PrEP) [12]. Although the Centers for Disease Control and Prevention launched several social marketing campaigns to increase HIV testing, it is unclear whether the HIV testing messages from these campaigns are reaching and resonating with young black men who may be at risk for infection. Prior qualitative research conducted with samples of young black men explored barriers to testing and prevention [13–16]. None of the studies explored whether HIV testing campaigns HEALTH EDUCATION RESEARCH Vol.34 no.1 2019
OP-JPEP180124 1..4

This special issue is dedicated to the memory of Dr. Dennis Drotar and his lasting impact on the field of pediatric adherence. Denny was born on January 13, 1945 in Elizabeth, New Jersey. He received his Bachelor of Arts in 1966 from Rutgers University, his Master of Arts in Psychology from the University of Iowa in 1968, and his PhD in Clinical Psychology from the University of Iowa in 1970. Denny was shaped by two formative experiences at the University of Iowa: (1) the novel training in pediatric psychology and (2) a clear understanding of the importance of good mentorship and training (mentor: Dr. Donald Routh). He completed his internship at Boston Children’s Hospital (1969) and postdoctoral fellowship at the University of Colorado Medical Center (1971). His first faculty position began in 1971 as an Assistant Professor of Psychology in Psychiatry and Pediatrics at Case Western Reserve University (CWRU) School of Medicine, where he became the first full-time psychologist at the affiliated Rainbow Babies and Children’s Hospital. His success was clear from the beginning, as Denny was quickly promoted throughout his career and became the Chief of the Division of Behavioral Pediatrics and Psychology at CWRU in 1996. For the last stage of his career, Denny chose to devote his time and efforts to the creation, development, and leadership of the Center for Adherence and Self-Management at Cincinnati Children’s Hospital Medical Center starting in 2007. In an editorial regarding his own personal reflections (Drotar, 2001), Denny stated that after his sister’s death when he was 20 years old, he was driven by the compelling question “What will you do with your life in the time that you have? ” The answer to this question could be measured by his track record of over 350 publications, continuous grant funding since 1972, or his countless number of successful mentees who are leaders in their respective fields. It could also be measured by the numerous awards Denny received throughout his career. In fact, his research career was so distinguished that the Society of Pediatric Psychology named their research award after Denny (Dennis Drotar Distinguished Research Award in Pediatric Psychology), which recognizes excellence and significant contributions in establishing the scientific base of pediatric psychology. As his mentees and the first faculty of the Center for Adherence and Self-Management, we can honestly say that, in the time that he had, Denny was truly a triple threat as researcher, clinician, and mentor. He had an extraordinary impact on science, which translated to the patients and families he and his trainees cared for, as well as the relationships he cultivated, the students and trainees he mentored, and the field of pediatric psychology as a whole. One can only aspire to approximate the impact Denny Drotar has had on science, mentoring, leadership, and clinical practice.
Classifying Vehicle Activity to Improve Point of Interest Extraction

Knowledge of drivers’ mobility patterns is useful for enabling context-aware intelligent vehicle functionality, such as route suggestions, cabin preconditioning, and power management for electric vehicles. Such patterns are often described in terms of the Points of Interest (PoIs) visited by an individual. However, existing PoI extraction methods are general purpose and typically rely on detecting periods of low mobility, meaning that when they are applied to vehicle data, they often extract a large number of false PoIs (for example, incorrectly extracting PoIs due to stopping in traffic), reducing their usefulness. To reduce the number of false PoIs that are extracted, we propose using features derived from vehicle signals, such as the selected gear and status of doors, to classify candidate PoIs and filter out those that are irrelevant. In this paper, we (i) present Activity-based Vehicle PoI Extraction (AVPE), a wrapper method around existing PoI extraction methods, that utilizes a postclustering classification stage to filter out false PoIs, (ii) evaluate the benefits of AVPE compared to three state-of-the-art general purpose PoI extraction algorithms, and (iii) demonstrate the effectiveness of AVPE when applied to real-world driving data.
Of Alloxan Induced Diabetic Rats

Natural substances have been used as a source of medicinal treatments for several decades and plants-based products playa critical role in the treatment of diabetes mellitus (DM) globally. This study was conducted to acquaintancethe effectiveness of gum Arabic (GA)on experimental rats suffered from diabetes mellitus.Thirty six mature male albino rats "Sprague Dawley" strain weighing (160±10 g), were used and divided into two main groups, one was kept as a negative control group (n =6) (G1), while the other was injected infra peritoneally with alloxan monohydrate by a single"'alose of alloxan (1S0mg/kg/B.W.) in 24 hrs fasting animal. This second main group divided into equal five groups (n =6);. The five diabetic groups were as the following; Group (2): was left as positive control and fed on basal diet only. Group (3): was fed on basal diet supplemented with diamacron drl1g1Smg Ikg diet.Group (4): was fed on basal diet supplemented with SO g GA (S%) Ikg diet. Group (5): was fed on basal diet supplemented with 100 g GA (10%)1 kg diet. Group (6): was fed
Yuwei Xu1 · Yin Tian2 · Bo Chen1 · Zijun Yan1 · Jie Ding1 · Yalin Huang1 · Jinyang Kang1 · Shanyong Chen1 · Yongdong Jin1 · Chuanqin Xia1

In this paper, porphyrin-based cationic conjugated network (PCCN) nanosheets were synthesized, and its adsorption for TcO4/ReO4 was investigated. This material was stacked with AB dislocation, with an aperture of 1.2 nm. The Re(VII)/ Tc(VII) adsorption kinetics of PCCN is extremely fast, and the adsorption capacity is relatively large, the selective order is ReO4 > NO3 > Cl−. XPS and DFT revealed that the exchange of Cl− on PCCN with ReO4, while the hydrophobic pore of PCCN are the keys to improve adsorption selectivity. It could be used to remove Tc from groundwater around nuclear facilities.
OP-JBIO180111 97..100

Organelles are intracellular compartments that are delineated by lipid bilayers and play specific roles in regulating various cellular events. Organelle dysfunction contributes to the pathological mechanisms of various diseases. The development and prevalence of super-resolved fluorescence microscopy have enabled the characterization of various functional regions and organellar dynamics by a number of cell biologists. These local functional organelle regions are named ‘zones’, and three review articles in this issue summarize three different organelle zones, namely, the ‘Response zone’, ‘Communication zone’ and ‘Sorting zone’. This newest organellar concept may shed light on a novel biological aspect and the elucidation of mechanisms of unresolved diseases.
OP-ICVA180322 728..734

OBJECTIVES: The purpose of this study was to develop a score to predict the complexity of video-assisted thoracoscopic surgery (VATS) lobectomies preoperatively. METHODS: One hundred and thirty-nine consecutive patients undergoing VATS lobectomy operated on by a single surgeon as the first operator were included. Complex operations were defined as: operation time >180 min (corresponding to the 75th percentile) or a conversion to thoracotomy. Several patient-related baseline and radiological variables were tested for a possible association with surgical complexity by logistic regression analysis. An aggregate score was created by weighing the regression estimates of the significant Presented at the 26th European Conference on General Thoracic Surgery, Ljubljana, Slovenia, 27–30 May 2018. VC The Author(s) 2018. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. Interactive CardioVascular and Thoracic Surgery 28 (2019) 728–734 ORIGINAL ARTICLE doi:10.1093/icvts/ivy319 Advance Access publication 29 November 2018 D ow naded rom http/academ ic.p.com /icvts/arti/5/728/5219002 by gest on 24 O cber 2021 predictors. Patients were then grouped in classes of risk according to their scores. Finally, the score was validated in an external population of 154 VATS lobectomy patients. RESULTS: Twenty-nine VATS lobectomies (21%) were classified as complex. The following variables were found to be significantly associated with a complex operation and were used to calculate the risk score in each patient (1 point each): male (P = 0.006), presence of thick pleura (P = 0.003), presence of emphysema (P = 0.001), enlarged hilar nodes (P = 0.003). Patients were grouped in 4 classes showing an incremental incidence of complex operations (P < 0.0001): score 0, 7.4%; score 1, 18%; score 2, 27%; score >2, 67%. In the external validation set, the score confirmed its association with the incidence of complex operations (P < 0.001): score 0, 7.3%; score 1, 10%; score 2, 16%; score >2 50%. CONCLUSIONS: The complexity score appeared to be reproducible in an external setting and can be used to preoperatively identify appropriate candidates for VATS lobectomies to improve the efficiency and safety of the training phase.
Numerical modelling of the growth of sulfate-reducing bacteria indigenous to an oilfield in Japan

Abstract We performed kinetic studies of the growth of sulfate-reducing bacteria (SRB) indigenous to the water in an oilfield in Japan. The SRB growth was most active in injection water supplemented with ethanol; therefore, the SRB inhabiting the injection water of the reservoir were assumed to grow predominantly by assimilating sulfate and ethanol and generating H2S. Based on this mechanism and the results of incubation experiments in the injection water, we derived numerical models that calculate the growth rate and H2S generation of the SRB under three variables (temperature, sulfate concentration, and ethanol concentration).
Ultrafast Pulsed Laser Induced Nanocrystal Transformation in Colloidal Plasmonic Vesicles

Plasmonic vesicle consists of multiple gold nanocrystals within a polymer coating or around a phospholipid core. As a multifunctional nanostructure, it has unique advantages of assembling small nanoparticles (<5 nm) for rapid renal clearance, strong plasmonic coupling for ultrasensitive biosensing and imaging, and near‐infrared light absorption for drug release. Thus, understanding the interaction of plasmonic vesicles with light is critically important for a wide range of applications. In this paper, a combined experimental and computational study is presented on the nanocrystal transformation in colloidal plasmonic vesicles induced by the ultrafast picosecond pulsed laser. Experimentally observed merging and transformation of small nanocrystals into larger nanoparticles when treated by laser pulses is first reported. The underlying mechanisms responsible for the experimental observations are investigated with a multiphysics computational approach featuring coupled electromagnetic/molecular dynamics simulation. This study reveals for the first time that combined nanoparticle heating and laser‐enhanced Brownian motion is responsible for the observed nanocrystal merging. Correspondingly, laser fluence, interparticle distance, and presence of water are identified as the most important factors governing the nanocrystal transformation. The guidelines established from this study can be employed to design a host of biomedical and nanomanufacturing applications involving laser interaction with plasmonic nanoparticles.
Stool Antigen Test is Effective and Sensitive for Detecting Helicobacter Pylori Infection in Bangladeshi Peptic Ulcer Patients

Aims: Helicobacter pylori (H. pylori) is the primary causative agent of peptic ulcer in multiple developing countries, including Bangladesh. This study was designed to investigate the diagnostic value of a rapid immunochromatography-based H. Pylori stool antigen (HpSAg) test to screen H. pylori infection in Bangladeshi population. Methodology and results: A total of 140 suspected peptic ulcer patients who underwent upper gastrointestinal endoscopy at Chittagong Medical College and Hospital, Chattogram, Bangladesh, were included in the study. Histopathology, Rapid Urease Test (RUT), and Microscopic examination of the stained smears were conducted to define H. pylori positive cases. Later, stool antigen detection test was done in H. pylori positive status group, H. pylori negative status group, indeterminate status group, and healthy controls. Out of 140 peptic ulcer suspected patients, 75 (53.6%) patients were confirmed to have peptic ulcer or erosions. Although the proportion of antral erosion was 57.4% in patients who were below 40 years, the proportion decreased to 23.4% in patients over 40 years. Patients over 40 years were mostly suffering from Prepyloric erosion (42.9%). All peptic ulcer patients were also positive on histopathological analysis. However, micorscopic grading of curved bacilli and RUT found 93.3% (70/75) and 89.3% (67/75) patients positive, respectively. High sensitivity (95%), specificity (80%), and diagnostic accuracy (91%) scores for HpSAg assay was obtained in our study. Conclusions, significance and impact of studies: The HpSAg test, for a comparatively less sophisticated assay, can be efficient in detecting the presence of H. pylori pre-and post-therapy and provide more valid test results than other invasive test methods.