Miracle-dz/UniFAR-FTUs huggingface dataset:
Lipoxin a 4 Stable Analogs Are Potent Mimetics That Stimulate Human Monocytes and THP-1 Cells via a G-protein-linked Lipoxin a 4 Receptor

Lipoxins (LX) are bioactive eicosanoids that activate human monocytes and inhibit neutrophils. LXA 4 is rapidly converted by monocytes to inactive products, and to resist metabolism, synthetic analogs of LXA 4 were designed. Here, we examined the bioactivity of several LXA 4 analogs in monocytes and found, for chemotaxis, 15( R/S )-methyl-LXA 4 and 15-epi-LXA 4 were equal in activity, and 16-phenoxy-LXA 4 was more potent than na- tive LXA 4 . Both 15( R/S )-methyl-LXA 4 and 16-phenoxy- LXA 4 were (cid:59) 1 log molar more potent than LXA 4 in stimulating THP-1 cell adherence (EC 50 (cid:39) 1 (cid:51) 10 (cid:50) 10 M ). Dimethylamide derivatives of the LXA 4 analogs also pos- sessed agonist rather than antagonist properties for monocytes. Neither LXA 4 nor 16-phenoxy-LXA 4 affected monocyte-mediated cytotoxicity. We cloned an LXA 4 receptor from THP-1 cells identical to that found in PMN. Evidence of receptor-mediated function of LXA 4 and the stable analogs in monocytes included desensitization of intracellular calcium mobilization to a second challenge report of monocyte stimulation by 15-epi-LXA 4 (aspirin-trig-gered LXA 4 ), 15( R/S )-methyl-LXA 4 , and 16-phenoxy-LXA 4 . These analogs were potent monocyte chemoattractants at 100 n M concentrations and 15( R/S )-methyl-LXA 4 and 16-phenoxy-LXA 4 were more potent in stimulating THP-1 cell adherence to laminin than native LXA 4 . These results suggest that structural changes made to the native molecule have decreased conversion to inactive products by monocytic cells because, as we recently reported, the monocyte products of LXA 4 , namely, 15-oxo-LXA 4 , 13,14-dihydro-15-oxo-LXA 4 , and 13,14- dihydro-LXA 4 , were virtually inactive in stimulating monocyte adherence (11). ,
Fibroblast Activation Protein (FAP) Overexpression Induces Epithelial – Mesenchymal Transition (EMT) in Oral Squamous Cell Carcinoma by Down-Regulating Dipeptidyl Peptidase 9 (DPP9)

Purpose: Fibroblast activation protein (FAP) acts as a tumor promoter via epithelial – mesenchymal transition (EMT) in human oral squamous cell carcinoma (OSCC). The present study was designed to investigate the FAP targeting proteins and explore the precise mechanism by which FAP promotes EMT in OSCC. Patients and Methods: Proteins interacting with FAP were found and ﬁ ltered by immu-noprecipitation-mass spectrometry (IP-MS). Both DPP9 protein and mRNA were examined in 90 paired OSCC samples and matched normal tissue. DPP9 knockdown was conducted to determine its function in OSCC in vitro and in vivo. Results: Dipeptidyl peptidase 9 (DPP9) was identi ﬁ ed as interacting with FAP intracellularly by IP-MS. The levels of both DPP9 protein and mRNA were down-regulated in OSCC tissue. Lower DPP9 expression was correlated with unfavorable survival rates of OSCC patients. DPP9 knockdown accelerates the proliferation of OSCC cells in vitro and in vivo. Overexpression of FAP leads to a reduction in DPP9 expression. Likewise, DPP9 overexpression reverses the proliferation, migration, invasion and EMT induced by FAP during OSCC. Conclusion: Our study ﬁ nds that FAP promotes EMT of OSCC by down-regulating DPP9 in a non-enzymatic manner. FAP-DPP9 pathway could be a potential therapeutic target of OSCC.
Towards gene therapy for rheumatoid arthritis

Introduction: Rheumatoid arthritis (RA) is an autoimmune disease of the joint, affecting 0.24% of the global population. Many patients only respond partially, do not respond or develop resistance to current treatments, and the severe systemic complications, including immunosuppression, are unacceptable. Genetic therapies for RA have the potential to improve treatments by targeting delivery to the disease site, enhancing efficacy and avoiding adverse effects. Areas covered: The route of administration, delivery vector, nucleic acid type and target gene must be carefully selected to develop an effective gene therapy for RA. Drawing from examples of RA gene therapies investigated in animal models and clinical trials, this review discusses how these strategies may be used to translate RA gene therapy into the clinic. Expert opinion: Existing RA treatments lack specificity to the joint. Genetic delivery systems can include targeting properties, such as disease-responsive promoters or cell-targeting moieties, to overcome this. Non-viral vectors in particular can be engineered easily to possess these properties and, unlike viral vectors, display low immunogenicity. Contrary to current drugs, gene therapy can be delivered intra-articularly, providing sustained levels of the therapeutic. Targeted vectors may also achieve this, but with a single systemic injection, simultaneously delivering the therapeutic to all affected joints.
Ilgalaikio antipsichotikø vartojimo sukeltos vëlyvosios diskinezijos gydymas: klinikiniø atvejø apraðymas ir literatûros apþvalga

was ini ti ated. Dur ing treat ment, the am pli tude of in vol un tary move ments par tially de creased and the pa tient be came more func tional. Lit er a ture re view. One of the dif fi cul ties in treat ing tardive dyskinesia in psy chi a try is the need to con tinue the antipsychotics that caused the con di tion. In this case, the best choice would be sec ond-gen er a tion atyp i cal antipsychotics. The first-line treat ment for tardive dyskinesia is VMAT2 in hib i tors – deutetra -benazine, valbenazine; if they are not avail able – tetrabenazine. Con clu sions. In or der to pro vide re li able ev i dence-based rec om men da tions for the treat ment of tardive dyskinesia and to better un der stand its pathophysiology, ge netic pre dis po si tion, and ther a peu tic agents, more stud ies with larger sam ples and more uni form con di tions are needed.
User-In-The-Loop Content Delivery in Cellular Communication Networks with Heterogeneous User Behaviors

User-in-the-loop (UiL) content delivery is a recently proposed scheme for personalized content retrieval over mobile communication networks. It is a promising scheme that can better manage the overall user quality-of-experience (QoE) throughout the entire content retrieval process. The performance of the scheme, however, has only been investigated in a simplified system model that assumed synchronized user behavior, inflexible delay constraint, and identical quality-of-service (QoS) requirement among users. This paper studies the performance of UiL content delivery scheme in a generalized and realistic system model with asynchronous user behavior, flexible outage delay constraint, and customized user QoS. Heuristic algorithms and theoretical bounds are investigated for the UiL content delivery problem. The proposed system is shown to be effective in managing the user QoE in generalized practical scenarios.
An overview of hybrid meson phenomenology

Models of hadrons based on quantum chromodynamics predict new forms of hadronic matter, referred to as hybrids, with both quarks and excited glue degrees of freedom. I review theoretical models of hybrids with the aim of finding features of hybrids which transcend specific models. The goal is to find signatures that can distinguish between hybrids and conventional hadrons.
Simulation of nanosilver migration from polystyrene nanocomposite into food simulants

Polystyrene granules were combined with nanosilver to form a nanocomposite film. One-side migration was conducted to test into three food simulants (3% acetic acid, 10% ethanol and 95% ethanol) at 40°C temperature on different period of time (2, 4, 6, 8 and 10 days). It was found that, among the simulants, the highest migration amount was obtained with 3% acetic acid, while the 95% ethanol revealed the least migration level. Diffusion coefficients of nanosilver particles into simulants were estimated by inverse simulation using experimental data of concentration variation in the simulants. The finite element method used to solve the mass transfer equation and the numerical results indicates the sameresponse with the experimental data. The numerical results confirmed that the highest diffusion coefficient for acetic acid 3% (1.82E-10 to 1.76E-9 m 2 s -1 ) and the lowest diffusion coefficient for ethanol 95% from 2 to 10 days were obtained, respectively. Also, results of diffusion coefficient – concentration relation showed, the diffusion coefficient had in direct correlation with time and concentration. The results indicated that, in the 3% acetic acid, due to the increasing of diffusion coefficient of silver nanoparticles, they are released faster and distributed uniformly. EOH, EOH 1.65 EOH. nanosilver migration increases by time simulating acetic two initial pented nanosilver subsequent nanosilver inter lamellar
CHEMICAL STUDIES ON THE ADRENAL CORTEX III. ISOLATION OF TWO NEW PHYSIOLOGICALLY INACTIVE COMPOUNDS*

In Paper II of this series (1) we described the isolation from adrenal extracts of four crystalline, nitrogen-free compounds, which were found to be physiologically inactive when tested on the adrenalectomized dog. Three of these compounds, besides others not encountered by us, have meanwhile been obtained independently by Reichstein (2) ;I the fourth is apparently identical with the substance designated as the adrenal cortical hormone by Kendall, Mason, McKenzie, Myers, and Koelsche (3). Analytical data obtained on these compounds in the various laboratories indicated the presence of 21 carbon atoms, and 5 oxygen atoms with varying functions. Reichstein subsequently showed that at least three of the compounds of this series (his Compounds A, C, and D) could be degraded to the same diketone C19H2~--2803, which possesses trong male sex hormone action and is in all probability closely related to androstanedione (4). This highly important observation, besides revealing a chemical relationship which might be concerned in the clinical syndrome of adrenal virilism, can be taken as strong presumptive evidence that the afore-
Coronary artery calcification progression among the United States and Japanese men: the Multi-Ethnic Study of Atherosclerosis (MESA) and Shia Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Background The risk of coronary heart disease remains low in Japan, although distributions of several coronary risk factors have become comparable to those in the United States (US). We prospectively compared coronary atherosclerosis burden, measured with coronary artery calcification (CAC) progression, between men in the 2 countries. Methods In 2 population-based samples of 1,712 White, Black, Hispanic, Chinese men in the US and 697 Japanese men in Japan aged 45–74 years without clinical cardiovascular disease, we quantified CAC progression by serial computed tomography with a median of 3.4 and 5.2 years between scans, respectively. Results Among White, and men of baseline incident CAC observed in 35.2%, 26.9%, and respectively. After adjustment for times between scans, demographics, behaviors, coronary risk factors, and their changes between scans, White men had significantly higher incident CAC than Japanese men (relative risk, 1.75; 95% confidence interval, 1.33, 2.29). Among those with detectable CAC at baseline, after similar adjustments, all the US race/ethnic groups had significantly greater annual changes in CAC score [mean (95% confidence interval), 39.4 (35.2, 43.6) for White; 26.9 (21.4, 32.4) Black; 30.6 (24.7, 36.5) for 30.2 37.8) for Chinese men] Japanese men (10.1, 21.8)]. Conclusion We found higher incident CAC among White men and greater increases in existing CAC among all the US race/ethnic groups than among Japanese men. These differences persisted despite adjustment for differences in coronary risk factors.
Holographic conﬁnement in inhomogeneous backgrounds

: As noted by Witten, compactifying a d -dimensional holographic CFT on an S 1 gives a class of ( d − 1)-dimensional conﬁning theories with gravity duals. The prototypical bulk solution dual to the ground state is a double Wick rotation of the AdS d +1 Schwarzschild black hole known as the AdS soliton. We generalize such ex-amples by allowing slow variations in the size of the S 1 , and thus in the conﬁnement scale. Coeﬃcients governing the second order response of the system are computed for 3 ≤ d ≤ 8 using a derivative expansion closely related to the ﬂuid-gravity correspondence. The primary physical results are that i) gauge-theory ﬂux tubes tend to align orthogonal to gradients and along the eigenvector of the Hessian with the lowest eigenvalue, ii) ﬂux tubes aligned orthogonal to gradients are attracted to gradients for d ≤ 6 but repelled by gradients for d ≥ 7, iii) ﬂux tubes are repelled by regions where the second derivative along the tube is large and positive but are attracted to regions where the eigenvalues of the Hessian are large and positive in directions orthogonal to the tube, and iv) for d > 3, inhomogeneities act to raise the total energy of the conﬁning vacuum above its zeroth order value.
Self Organizing Networks: A Self-Healing Framework

The 3 rd Generation Partnership Project (3GPP) initiated successor of UMTS called Long Term Evolution in its 8 th release. In its first (8 th ) and subsequent releases, it included Self Organizing Network (SON) that promises improvements for future wireless network. Fault Management is an important aspect of SON aiming to automatically diminish the fault by triggering appropriate recovery needed and hence satisfy the operator-specified performance requirements as much as possible. This paper aims to present a Self-healing framework and analyzes the various use-cases and control parameters including Physical Channel Transmit Power, antenna tilt and uplink target received power level P 0.
FUNC TI ON IN G IN PAT IE NT S W ITH S YS TE MI C LU P US ER YTH E MAT OS US

Background Sexual problems are common in patients with chronic illnesses. However, few studies have investigated problems with sexual functioning in patients with systemic lupus erythematosus (SLE). The present cross-sectional study assessed the influence of SLE on sexual functioning and its associations with illness perceptions and medical and socio-demographic characteristics. Methods The study included 106 SLE patients who used at least one immunosuppressive agent to control their SLE. Sexual functioning was measured using the Physical Disability Sexual and Body Esteem and the Medical Impact Scale from the Sexual Functioning Questionnaire. Patients’ illness perceptions were assessed using the Brief Illness Perception Questionnaire. Results 49.1% of patients agreed that their SLE had a negative influence on their sexual functioning. In addition, treatment for SLE seemed to play an important role in the negative impact on sexual functioning. Patients’ illness perceptions were more important predictors of sexual functioning than medical and socio-demographic characteristics. SLE patients appear to report a lower sexual functioning than patients with other chronic illnesses. Conclusion SLE in general and immunosuppressive treatment for SLE specifically have a negative influence on sexual functioning. Patients’ illness perceptions appear to play a more important role in the negative impact on sexual functioning than medical characteristics such as disease activity. The high prevalence of sexual problems highlights the need to more frequently address and aim to improve sexual functioning in patients with SLE. Patients may benefit from methods such as illness perception modification and coping style interventions to reduce their sexual problems. of SLE and its treatment on patients’ sexual functioning. The results showed that half of the patients experienced negative effects of SLE in general on their sexual functioning, especially on their sexual esteem and body esteem. In addition, treatment for SLE specifically seemed to play an important role in the negative influence on sexual functioning. Patients’ illness perceptions were more
Numerical analysis and experimental studies on solenoid common rail diesel injector with worn control valve

A mathematical model of a solenoid common rail fuel injector was developed. Its difference from existing models is control valve wear simulation. A common rail injector of 0445110376 Series (Cummins ISf 2.8 Diesel engine) produced by Bosch Company was used as a research object. Injector parameters (fuel delivery and back leakage) were determined by calculation and experimental methods. GT-Suite model average R2 is 0.93 which means that it predicts the injection rate shape very accurately (nominal and marginal technical conditions of an injector). Numerical analysis and experimental studies showed that control valve wear increases back leakage and fuel delivery (especially at 160 MPa). The regression models for determining fuel delivery and back leakage effects on fuel pressure and energizing time were developed (for nominal and marginal technical conditions).
Title : Preoperative lymphocyte-to-monocyte ratio in the prognostication of advanced resectable colon cancer: A retrospective observational study

Background: Lymphocyte-to-monocyte ratio (LMR) has been reported as a biomarker for predicting the prognosis of colorectal cancer. However, proof of the clinical usefulness of LMR requires detailed research on subjects that can contribute to therapeutic strategies. Our study aimed to provide a detailed link to resectable advanced colorectal cancer for which LMR is predicted to be particularly useful. Methods: A cohort of 554 resectable advanced colon cancer patients in our institution was analysed retrospectively. The analysis was performed on all cases of resectable advanced colon cancer and Stage II and Stage III. Receiver operating characteristic curve analyses were performed to determine the LMR cut-off value. The relationship between LMR, clinicopathologic factors, and other biomarkers were analysed using a Kaplan-Meier log-rank survival analysis and then multivariate Cox regression models looking for association with overall survival (OS) and Relapse free survival (RFS). Results: LMR was useful for predicting OS and RFS in the analysis of all cases. Moreover, it was an independent prognostic factor in the multivariate analysis [hazard ratio (HR)= 0.530, 95% confidence intervals (CI)= 0.334–0.842, P=0.007]. LMR was also an independent prognostic predictor at each stage. In particular, it was highly useful for prediction in cases with lymph node metastasis (Stage Ⅲ ) and was a prognostic predictor following the N factor. Conclusion: LMR is useful in the prognosis of resectable advanced colon cancer. In addition, it may be characterised by having a high effect on the prognosis of patients with lymph node metastasis. This study may influence postoperative strategies for colon cancer, such as the study of Stage III chemotherapy indications, and is expected to facilitate further detailed studies. were into the “high” (H group) and “low” (L group) LMR groups. Patient baseline characteristics in each LMR group were compared using the χ 2 and Fisher’s exact test. The association of LMR with overall survival (OS) and recurrence-free survival (RFS) was analysed using the Kaplan-Meier method and log-rank test. Multivariate Cox regression analyses were also performed. All statistical analyses were performed with the Statistical Package for Social Science (SPSS) software package (SPSS Inc., Tokyo, Japan). P-values <0.05 were considered to indicate statistical significance.
Radio frequencies for the Internet of Things: A new paradigm for engineers

: The Internet of Things (IoT) is going to generalize the use of radio waves to connect devices of varied sorts: new uses but also new constraints. Short, infrequent messages emitted by millions of devices cannot be managed like downloads of videos or online gaming. The IoT forces us to rethink the assignment of bandwidths and adapt communication protocols. Sigfox network invented such an approach with its ultra narrowband technology, a paradigm that the cellular and satellite IoTs have taken into account. Since the radio-frequency spectrum necessary for the IoT is small in comparison with other uses, we can imagine that a bandwidth would be devoted to the IoT. Such a bandwidth, if harmonized worldwide, would be conducive to the emergence of global solutions for the Internet of Things.
Introduction to the Global Attractor Conjecture

The roots of the Global Attractor Conjecture (GAC) can be found in the 1972 paper “General Mass Action Kinetics” by Fritz Horn and Roy Jackson [9]. The paper is noted for presenting a general network-based framework for studying mass action systems and is often credited with initiating the research area known as Chemical Reaction Network Theory (CRNT). This area has seen a significant resurgence of interest in recent years as systems biology has gained prominent within the life sciences, computer science, and mathematics. The GAC itself arises from a particular ordinary differential equation model arising from chemical kinetics known as a mass action system. For complex balanced systems, Horn and Jackson were able to prove some very strong results regarding the steady states and dynamics of the standard ordinary differential equation (ODE) model. In fact, they were able to define a global Lyapunov function which guaranteed that trajectories of such systems were required, as if by gravitational force, to tend toward the complex balanced steady state from anywhere else in the state space. The natural conclusion is that all trajectories asymptotically approach the complex balanced state; that is, that the unique state at the bottom of the valley defined by the Lyapunov function is a global attractor. This temptation was so strong, in fact, the authors errantly claimed they had proved this. The authors were unable, however, to eliminate the possibility that trajectories approached the boundary of the state space rather than the complex balanced steady state. As such, they retracted the claim in 1974. This small gap, which extends the local stability guaranteed by the Lyapunov function to global stability, is the content of the Global Attractor Conjecture. The conjecture has resisted proof for over 40 years but is now claimed to have been solved by Gheorghe Craciun. His 41 page manuscript “Toric Differential Inclusions and a Proof of the Global Attractor Conjecture” incorporates complex ideas from algebraic geometry, differential inclusions, and dynamical systems. It is the purpose of this write-up to present the background from “General Mass Action Kinetics” necessary to understand and appreciate the importance—and frustration—associated with the Global Attractor Conjecture.