Miracle-dz/UniFAR-FTUs huggingface dataset:
Formulation of water-soluble Buddleja globosa Hope extracts and characterization of their antimicrobial properties against Pseudomonas aeruginosa

Buddleja globosa Hope (BG) extracts are traditionally used to treat skin and gastric ulcers due to their healing properties. Non-aqueous solvents such as ethanol and DMSO are usually used to extract naturally occurring compounds. However, the cytotoxicity of these solvents and the low water solubility of the extracted compounds can hinder their biomedical applications. To overcome the limited solubility of the BG extracts, we aimed to enhance the solubility by processing a standardized hydroalcoholic extract (BG-126) through spray drying (SD), with and without two solubility enhancers. Spray-dried BG (BG-SD) extracts and spray-dried BG extracts plus polyvinylpyrrolidone (BG-SD PVP) and Soluplus® (BG-SD SP) were developed starting from BG-126 (containing 53% ethanol). These four formulations were characterized by total phenolic content, water solubility at 25°C and 37°C, and antimicrobial properties against Pseudomonas aeruginosa. All the SD formulations presented a solubility that allowed them to reach maximum concentrations of 1,024 μg/ml catechin for BG-SD and 2,048 μg/ml catechin for BG-SD PVP and BG-SD SP for antimicrobial testing. BG-SD showed the highest antimicrobial potency with a minimum inhibitory concentration (MIC) of 512 μg/ml catechin, followed by BG-126 with a MIC of 1,024 μg/ml catechin and SP. BG-126 was also shown to inhibit biofilm formation, as well as the excipients PVP and SP. The spray-dried BG (BG-SD) extract represents a promising natural active component with enhanced antimicrobial properties against P. aeruginosa for further research and the development of novel phytopharmaceuticals.
Case report of old anterior dislocation of the shoulder joint and review of the literature

Background Dislocation of the shoulder joint is the most common type of joint dislocation. It is rare to be in a persistent dislocation that has not been reset. Successful arthroscopic treatment of the obsolete shoulder is relatively uncommon. Case report We report a rare case of persistent anterior dislocation of the old shoulder joint in a 30-year-old female patient. The patient underwent an emergency shoulder dislocation at a local hospital after a traumatic injury and re-dislocated persistently after surgery. 26 days later, she was admitted to our department for treatment, mainly because of joint deformity and limitation of motion. We adopted arthroscopic release and repositioning surgery. The patient was followed up for 1 year after surgery. Functional recovery was satisfactory. Conclusion The state of obsolete shoulder dislocation rarely occurs after shoulder dislocation and the prognosis of the patient is good after complete arthroscopic release and repositioning. It provides a reference for clinical arthroscopic treatment of old shoulder dislocations.
Endocrine and paracrine characteristics of neuroendocrine prostate cancer

Prostate cancer is a common malignancy affecting men worldwide. While the vast majority of newly diagnosed prostate cancers are categorized as adenocarcinomas, a spectrum of uncommon tumor types occur including those with small cell and neuroendocrine cell features. Benign neuroendocrine cells exist in the normal prostate microenvironment, and these cells may give rise to primary neuroendocrine carcinomas. However, the more common development of neuroendocrine prostate cancer is observed after therapeutics designed to repress the signaling program regulated by the androgen receptor which is active in the majority of localized and metastatic adenocarcinomas. Neuroendocrine tumors are identified through immunohistochemical staining for common markers including chromogranin A/B, synaptophysin and neuron specific enolase (NSE). These markers are also common to neuroendocrine tumors that arise in other tissues and organs such as the gastrointestinal tract, pancreas, lung and skin. Notably, neuroendocrine prostate cancer shares biochemical features with nerve cells, particularly functions involving the secretion of a variety of peptides and proteins. These secreted factors have the potential to exert local paracrine effects, and distant endocrine effects that may modulate tumor progression, invasion, and resistance to therapy. This review discusses the spectrum of factors derived from neuroendocrine prostate cancers and their potential to influence the pathophysiology of localized and metastatic prostate cancer.
Exploring the effects and mechanisms of organophosphorus pesticide exposure and hearing loss

Many environmental factors, such as noise, chemicals, and heavy metals, are mostly produced by human activities and easily induce acquired hearing loss. Organophosphorus pesticides (OPs) constitute a large variety of chemicals and have high usage with potentiate damage to human health. Moreover, their metabolites also show a serious potential contamination of soil, water, and air, leading to a serious impact on people's health. Hearing loss affects 430 million people (5.5% of the global population), bringing a heavy burden to individual patients and their families and society. However, the potential risk of hearing damage by OPs has not been taken seriously. In this study, we summarized the effects of OPs on hearing loss from epidemiological population studies and animal experiments. Furthermore, the possible mechanisms of OP-induced hearing loss are elucidated from oxidative stress, DNA damage, and inflammatory response. Overall, this review provides an overview of OP exposure alone or with noise that leads to hearing loss in human and experimental animals.
E3 ubiquitin ligases in the acute leukemic signaling pathways

Acute leukemia is a common hematologic tumor with highly genetic heterogeneity, and many factors are involved in the pathogenesis and drug-resistance mechanism. Emerging evidence proves that E3 ubiquitin ligases participate in the acute leukemic signaling pathways via regulating substrates. This review summarized the E3 ligases which can affect the leukemic signal. It is worth noting that the abnormal signal is often caused by a deficiency or a mutation of the E3 ligases. In view of this phenomenon, we envisioned perspectives associated with targeted agonists of E3 ligases and proteolysis-targeting chimera technology. Moreover, we emphasized the significance of research into the upstream factors regulating the expression of E3 ubiquitin ligases. It is expected that the understanding of the mechanism of leukemic signaling pathways with which that E3 ligases are involved will be beneficial to accelerating the process of therapeutic strategy improvement for acute leukemia.
COVID-induced 3  weeks’ treatment delay may exacerbate breast cancer patient’s psychological symptoms

The delayed access to cancer treatment due to the outbreak of COVID-19 pandemic posed a unique challenge to breast cancer patients and caused a significant level of mental distress among them. In the current research, we examined the psychological impacts of COVID on a subpopulation of breast cancer patients from a hospital in Shaanxi province of China using Symptom Checklist-90-R (SCL-90-R). Participants were 195 breast cancer patients at the outpatient clinic of Xijing hospital, Xi’an, Shaanxi Province, China. We found that a treatment delay of more than 3 weeks may exacerbate breast cancer patients’ psychological symptoms, such as somatization, obsessive–compulsive disorder, interpersonal sensitivity, depression, hostility, phobic anxiety, paranoid ideation, and psychoticism, whereas a short-term delay of less than 3 weeks is less likely to have a significant effect on one’s mental well-being. Additionally, breast cancer survivors, especially those at more advance stages, tend to experience more elevated psychological symptoms with longer treatment delay, and whose treatments continues to be delayed reported stronger psychological symptoms than individuals whose treatment are resumed, regardless of treatment type.
Ising model: Elementary excitation and nonsingular heat capacity at critical temperature

We find a new parameter vector q to describe spin correlations and fluctuation characteristics. The conservation of scalar q indicates there are simple harmonic motions of q, and the motion quantum is called block-spin phonon like the phonon in a crystal, resulting in nonsingular heat capacity at T . The harmonic motions show there are hierarchies and symmetries of fluctuations, and the soft modes lead to the interactions of block-spin phonons of different frequencies.
Bootstrapping Newtonian gravity

A non-linear equation obtained by adding gravitational self-interaction terms to the Poisson equation for Newtonian gravity is here employed in order to analyse a static spherically sym- metric homogeneous compact source of given proper mass and radius and the outer vacuum. The main feature of this picture is that, although the freedom of shifting the potential by an ar- bitrary constant is of course lost, the solutions remain qualitatively very close to the Newtonian behaviour. We also notice that the negative gravitational potential energy is smaller than the proper mass for sources with small compactness, but for sources that should form black holes according to General Relativity, the gravitational potential energy becomes of the same order of magnitude of the proper mass, or even larger. Moreover, the pressure overcomes the energy density for large values of the compactness, but it remains finite for finite compactness, hence there exists no Buchdahl limit. This classical description is meant to serve as the starting point for investigating quantum features of (near) black hole configurations within the corpuscular picture of gravity in future developments.
Alleviating Constraints or Targeting the Unsophisticated? The Government-led Household Credit Expansion in Brazil

From 2011 to 2014, the Brazilian government conducted a heavily advertised major credit expansion program through government-owned banks. Using administrative data on individual-level borrowing and spending, we find that the program led to a substantial rise in borrowing by public sector employees, especially those that were less financially sophisticated. Real interest rates on the debt were high, and they did not fall materially during the expansion. As a result of the borrowing done in the expansion, less financially sophisticated public sector workers experienced higher consumption volatility and lower average consumption through the 2011 to 2016 business cycle. Individuals more likely to face a borrowing constraint did not increase borrowing during the credit expansion.
Hybrid of superconducting quantum interference device and atomic Bose-Einstein condensate: An architecture for quantum information processing

A hybrid quantum system is proposed by coupling the internal hyperfine transitions of a trapped atomic Bose-Einstein condensate (BEC) and a superconducting quantum interference device (SQUID) via the macroscopic quantum field of the flux qubit. The presence of the condensate leads to a bosonic enhancement of the Rabi frequency over the otherwise small single-particle magnetic dipole transition matrix elements. This enhancement allows for the possibility to rapidly transfer and store qubit states in the BEC that were originally prepared in the SQUID. The fidelity of this transfer for different states is calculated, and a direct experimental protocol to determine the transfer fidelity by quantum tomography of the BEC qubit is presented.
Intense Electromagnetic Outbursts from Collapsing Hypermassive Neutron Stars

We study the gravitational collapse of a magnetized neutron star using a novel numerical approach able to capture both the dynamics of the star and the behavior of the surrounding plasma. In this approach, a fully general relativistic magnetohydrodynamics implementation models the collapse of the star and provides appropriate boundary conditions to a force-free model which describes the stellar exterior. We validate this strategy by comparing with known results for the rotating monopole and aligned rotator solutions and then apply it to study both rotating and non-rotating stellar collapse scenarios, and contrast the behavior with what is obtained when employing the electrovacuum approximation outside the star. The non-rotating electrovacuum collapse is shown to agree qualitatively with a Newtonian model of the electromagnetic field outside a collapsing star. We illustrate and discuss a fundamental difference between the force-free and electrovacuum solutions, involving the appearance of large zones of electric-dominated field in the vacuum case. This provides a clear demonstration of how dissipative singularities appear generically in the non-linear time-evolution of force-free fluids. In both the rotating and non-rotating cases, our simulations indicate that the collapse induces a strong electromagnetic transient. In the case of sub-millisecond rotation, the magnetic field experiences strong winding and the transient carries much more energy. This result has important implications for models of gamma-ray bursts.
EVN OBSERVATIONS OF HESS J1943+213: EVIDENCE FOR AN EXTREME TeV BL Lac OBJECT

We report on the 1.6 GHz (18 cm) very long baseline interferometry (VLBI) observations of the unresolved, steady TeV source HESS J1943+213 located in the Galactic plane, performed with the European VLBI Network (EVN) in 2014. Our new observations with a nearly full EVN array provide the deepest image of HESS J1943+213 at the highest resolution ever achieved, enabling us to resolve the long-standing issues of the source identification. The milliarcsecond-scale structure of HESS J1943+213 has a clear asymmetric morphology consisting of a compact core and a diffuse jet-like tail. This is broadly consistent with the previous e-EVN observations of the source performed in 2011 and re-analyzed in this work. The core component is characterized by the brightness temperature of ≳ 1.8 × 10 9 K, which is typical for low-luminosity blazars in general. Overall, the radio properties of HESS J1943+213 are consistent with the source classification as an “extreme high-frequency-peaked BL Lac object. ” Remarkably, we note that because HESS J1943+213 does not reveal any optical or infrared signatures of the active galactic nucleus activity, it would never be recognized and identified as a BL Lac object if not for its location close to the Galactic plane where the High Energy Stereoscopic System surveyed for and the follow-up dedicated X-ray and radio studies triggered by the source detection in the TeV range. Our results suggest, therefore, a presence of an unrecognized, possibly very numerous population of particularly extreme HBLs and simultaneously demonstrate that the low-frequency VLBI observations with high angular resolution are indispensable for a proper identification of such objects.
Analyzing the Influence of Resource Prioritization on HTTP/3 HOL Blocking and Performance

—HTTP/3 comes with a significant change on the transport layer by switching from TCP to QUIC. Of particular interest is that QUIC features independent streams which removes transport HOL blocking during packet loss: loss-unaffected streams no longer have to wait for full retransmissions of affected streams which was the case for HTTP/2. To leverage this new capability, multiple streams have to be in flight at the same time. This can, e.g., be governed by HTTP resource prioritization which allows a browser to signal its desired scheduling of streams to improve web performance. For HTTP/2, sequential scheduling, as used by Chrome, has proven to achieve good results. This choice, however, prevents QUIC’s independent streams from taking effect. In contrast, round-robin scheduling could exploit this specific feature best, but it has shown detrimental effects for HTTP/2. Yet, in that case, it could not benefit from independent streams. Whether round-robin is now beneficial with HTTP/3 is unknown, as the interplay of resource prioritization and HOL blocking on performance for HTTP/3 is unexplored. Since the alleviation of HOL blocking is one of the main features of QUIC, we thus analyze its impact and influencing factors. We find that for bursty loss, e.g., from congestion, sequential scheduling achieves good web performance, but that parallelism can help for increasing random loss rates. Nevertheless, for moderate loss, parallelism taking priorities into account is more helpful than agnostic round-robin.
The population of M-type supergiants in the starburst cluster Stephenson 2

The open cluster Stephenson 2 contains the largest collection of red supergiants known in the Galaxy, and at present is the second most massive young cluster known in the Milky Way. We have obtained multi-epoch, intermediate-resolution spectra around the Ca ii triplet for more than 30 red supergiants in Stephenson 2 and its surroundings. We find a clear separation between a majority of RSGs having spectral types M0-M2 and the brightest members in the NIR, which have very late spectral types and show strong evidence for heavy mass loss. The distribution of spectral types is similar to that of RSGs in other clusters, such as NGC 7419, or associations, like Per OB1. The cluster data strongly support the idea that heavy mass loss and maser emission is preferentially associated with late-M spectral types, suggesting that they represent an evolutionary phase.
Urogenital dysfunction following neurotrauma

Purpose of review Trauma affecting the nervous system can have widespread consequences, depending on the location and severity of injury. The sensorimotor and cognitive deficits due to neurotrauma have been studied extensively. Although the overall mortality due to neurotrauma has reduced, the disability and morbidity due to neurotrauma has not significantly reduced and focus on urogenital disturbances in these patients has been limited. This article reviews the limited evidence and scientific literature on this topic. Recent findings Lower urinary tract symptoms are commonly reported in patients with neurotrauma, both acutely and over the long term. Multiple medical and surgical approaches are available for managing bladder dysfunction in these patients. Sexual dysfunction and changes in sexual behaviour are reported by patients with neurotrauma and are usually multifactorial. Treatment options for sexual dysfunction are available and their management requires a holistic approach. Summary Urogenital dysfunction contributes significantly to the overall functional outcome and impaired quality of life in patients with neurotrauma. A better understanding of the mechanisms behind the urogenital abnormalities is needed for efficient management and treatment.
Tree-based Unidirectional Neural Networks for Low-Power Tree-based Unidirectional Neural Networks for Low-Power Computer Vision Computer Vision

—This article describes the novel Tree-based Unidirec- tional Neural Network (TRUNK) architecture. This architecture improves computer vision efﬁciency by using a hierarchy of multiple shallow Convolutional Neural Networks (CNNs), instead of a single very deep CNN. We demonstrate this architecture’s versatility in performing different computer vision tasks efﬁciently on embedded devices. Across various computer vision tasks, the TRUNK architecture consumes 65% less energy and requires 50% less memory than representative low-power CNN architectures, e.g., MobileNet v2, when deployed on the NVIDIA Jetson Nano.
Reducing Underkill Using Unsupervised Machine-Learning Based Method in Analog/RF IC Testing

—Semiconductor manufacturers strive to maintain a balance between the reliability expectations of System On Chips (SOCs) and ensuring the overall cost of testing is low. Amongst manufacturers, there exists a strong desire to achieve minimal Defective Parts Per Billion (DPPB) as loss of yield is often exacerbated by the exponentially increasing complexity of devices in current technology nodes.Most semiconductor manufacturers balance the need for extensive testing and the additive overhead of test cost and test time associated with it, resulting in manufacturers having exceedingly optimistic device binning or insufficiently elaborate test programs. The aforementioned issues in high-volume manufacturing testing cause faulty or failure-prone ICs to be shipped out and increase the number of customer returns. We term this unfavorable test outcome as Underkill. To this end, we propose an unsupervised machine learning-based methodology to identify potential customer returns and thus reduce Underkill. Specifically, the proposed machine learning model captures any deviations in device behavior across different test insertions. Leveraging unsupervised machine learning models, we extract unique signatures from these devices and use Gaussian methods to learn from the distribution and identify one or more devices that may be a potential customer return(s). We employ our proposed approach on an industrial dataset provided to us by Texas Instruments. Our experimentation with the industrial dataset establishes effectiveness in correctly identifying devices with a higher probability of failure on-site.
POWER CALCULATION AND STUDY DESIGN IN RNA-SEQ AND METHYL-SEQ by

Next generation sequencing (NGS) technology has emerged as a powerful tool in characterizing genomic profiles. Among several applications, RNA sequencing (RNA-Seq) and Methylation sequencing (Methyl-Seq) have gradually become standard tools for transcriptomic and epigenetic monitoring respectively. Although the costs of NGS experiments have constantly decreased, high sequencing cost and bioinformatic complexity remain obstacles for many biomedical projects. Unlike earlier microarray technologies, modeling of NGS data should consider discrete count data. In addition to sample size, sequencing depth is also directly related to experimental costs. Consequently, given a total budget and a pre-specified unit experimental cost, the study design issue in RNA-Seq/Methyl-Seq is a multi-dimensional constrained optimization problem rather than a one-dimensional sample size calculation in a traditional hypothesis setting. In the first part of this dissertation, we proposed a statistical framework, namely “RNASeqDesign”, to utilize pilot data for power calculation and study design of RNA-Seq experiments. The approach was based on a mixture model fitting of the p-value distribution from pilot data and a parametric bootstrap procedure to infer genome-wide power for optimal sample size and sequencing depth. We further illustrated five practical study design tasks for practitioners. We performed simulations and real data applications to evaluate performance and compare to existing methods. In the second part, we proposed another statistical framework, namely “MethylSeqDesign”, specifically for Methyl-Seq data. There were mainly two challenges. Firstly, the statis-
Gaussian curvature and global effects: Gravitational Aharonov-Bohm effect revisited

Using the Gauss-Bonnet formula, integral of the Gaussian curvature over a 2-surface enclosed by a curve in the asymptotically flat region of a static spacetime was found to be a measure of a gravitational analogue of Aharonov-Bohm effect by Ford and Vilenkin in the linearized regime. Employing the 1+3 formulation of spacetime decomposition we study the same effect in the context of full Einstein field equations for stationary spacetimes. Applying our approach to static tube-like and cylindrical distributions of dust not only we recover their result but also obtain an extra term which is interpreted to be representing the classical version of the Colella-Overhauser-Werner effect (the COW experiment).