Miracle-dz/UniFAR-FTUs huggingface dataset:
Cox model and decision trees: an application to breast cancer data

ABSTRACT Objective. To evaluate, using semiparametric methodologies of survival analysis, the relationship between covariates and time to death of patients with breast cancer, as well as the determination discriminatory power in the conditional inference tree of patients who had cancer. Methods. A retrospective cohort study was conducted using data collected from medical records of women who had breast cancer and underwent treatment between 2005 and 2015 at the Hospital da Fundação de Assistencial da Paraíba in Campina Grande, State of Paraiba, Brazil. Survival curves were estimated using the Kaplan–Meier method, Cox regression, and conditional decision tree. Results. Women with triple-negative molecular subtypes had a shorter survival time compared to women with positive hormone receptors. The addition of hormone therapy reduced the risk of a patient dying by 5.5%, and the risk of a HER2-positive patient dying was 34.5% lower compared to those who were negative for this gene. Patients undergoing hormone therapy had a median survival time of 4 753 days. Conclusions. This paper shows a favorable scenario for the use of immunotherapy for patients with HER2 overexpression. Further studies could assess the effectiveness of immunotherapy in patients with other conditions, to favor the prognosis and better quality of life for the patient.
Indoor localization using FM radio and DTMB signals

Indoor localization systems based on Wi‐Fi signal strength fingerprinting techniques are widely used in office buildings. However, a general problem of these systems pertains to Wi‐Fi signal degradation due to the environmental factors. And also, these systems cannot be used in the environments not covered with Wi‐Fi signals or the environments with only a single Wi‐Fi access point. In this paper, a new indoor location fingerprinting system using both FM radio and Digital Television Terrestrial Multimedia Broadcasting (DTMB) signals is proposed. First, the indoor location fingerprinting using FM radio and DTMB signals is theoretically analyzed to confirm its feasibility. Then, a specially designed combined strength fingerprinting location algorithm is proposed for the location system, which is achieved on the USRP2 platform. Finally, the system is tested in a typical indoor environment. The theoretical analysis and the tests show that the indoor location fingerprinting system using FM radio and DTMB signals has a similar localization accuracy to the Wi‐Fi signal strength fingerprinting location system, while it has a wider coverage area, a lower maintenance cost, and more stable signal strength, which makes it a practical indoor positioning method.
Disciplinary Links Between Scientific Management and Strategy Development

We investigate the incidence of links between the historical discipline of scientific management and the modern study of strategy development. Despite a century’s separation, these two disciplines share noticeable commonality in their trajectories and their approach to management. We conducted a forward search of the impact of scientific management, finding influences on accounting, human resource management, and the creation of the modern MBA. We then conducted a backward search of the roots of strategy development, including a novel directed reference tree search by citation count. We find overlap between these two searches in organization theory, operations research, and industrial psychology. Further, we identify disciplinary oscillation between quantitative process studies and context­ based ethnographic research in the study of management questions. Introduction Almost 100 years have passed since Frederick W. Taylor published his book “The principles of Scientific Management. ” During these timeframe, his work has been acclaimed, criticized, interpreted and re‐interpreted having vast influence in modern engineering systems. In particular, Scientific Management has influenced the emergence of management as a discipline (Wren, 2005), Organization Theory (March & Simon, 1958);(Scott & Davis, 2006), and Operations Research (Gass, 2005). This first part of this article will describe the historical context in which Scientific Management was born, the main proponents of its ideas, and impact it had on these different fields. The second part of this article investigates the historical roots of strategy development, a contemporary methodology. Strategy development will be tracked from its origins in economics, management, and sociology from the 1940s through the 1990s, as represented by the work of Porter (1991) and Mintzberg (1990). Through the intersection of these two analyses, we will determine the extent of the influence of Scientific Management on the emergence of Strategy Development as a field. The Historical Context of Scientific Management: The Progressive Era
A Journey in the History of Sovereign Defaults on Domestic-Law Public Debt

We introduce a novel database on sovereign defaults that involve public debt instruments governed by domestic law. By systematically reviewing a large number of sources, we identify 134 default and restructuring events of domestic debt instruments, in 52 countries from 1980 to 2018. Domestic-law defaults are a global phenomenon. Over time, they have become larger and more frequent than foreign-law defaults. Domestic-law debt restructurings proceed faster than foreign ones, often through extensions of maturities and amendments to the coupon structure. While face value reductions are rare, net-present-value losses for creditors are still large. Unilateral amendments and post-default restructuring are the norm, but negotiated pre-default restructurings are becoming increasingly frequent. We also document that domestic-law defaults typically involve debt denominated in local currency and held by resident investors. We complement our analysis with a collection "sovereign histories", which provide the fine details about each episode.
APPROACH TO HYPONATREMIA ACCORDING TO THE CLINICAL SETTING. CONSENSUS 1 STATEMENT FROM THE ITALIAN SOCIETY OF ENDOCRINOLOGY (SIE), ITALIAN SOCIETY OF 2 NEPHROLOGY (SIN) AND ITALIAN ASSOCIATION OF MEDICAL ONCOLOGY (AIOM)

1 APPROACH TO HYPONATREMIA ACCORDING TO THE CLINICAL SETTING. CONSENSUS 1 STATEMENT FROM THE ITALIAN SOCIETY OF ENDOCRINOLOGY (SIE), ITALIAN SOCIETY OF 2 NEPHROLOGY (SIN) AND ITALIAN ASSOCIATION OF MEDICAL ONCOLOGY (AIOM) 3 4 Emilia Sbardella *, Andrea M. Isidori *, Giorgio Arnaldi, Maura Arosio, Carlo Barone, Andrea Benso, Rossana 5 Berardi, Gianni Capasso, Massimiliano Caprio, Filippo Ceccato, Giovanni Corona, Silvia Della Casa, Luca De 6 Nicola, Marco Faustini-Faustini, Enrico Fiaccadori, Loreto Gesualdo, Stefania Gori, Andrea Lania, Giovanna 7 Mantovani, Paolo Menè, Gabriele Parenti, Carmine Pinto, Rosario Pivonello, Paola Razzore, Giuseppe 8 Regolisti, Carla Scaroni, Francesco Trepiccione, Andrea Lenzi and Alessandro Peri, 9
ANALISIS STABILITAS LERENG PADA TIMBUNAN TPA DENGAN PENDEKATAN ELEMEN HINGGA

Analisis stabilitas lereng pada model timbunan sampah (landfill) dengan metode elemen hingga digunakan untuk memperoleh nilai faktor keamanan, serta pengaruh terhadap nilai suction dan pengaruh terhadap aliran air pada kondisi tanah jenuh sebagian. Model timbunan memiliki tinggi lereng 20 meter, dengan kemiringan 1V:2H, dan terdiri dari beberapa lapisan. Penelitian ini dilakukan pada konstruksi bertahap (staged construction) lereng dengan model tanah Mohr Coulomb. Pemodelan stabilitas lereng memvariasikan debit hujan, penggunaaan lapis perkuatan geotekstil dan pemodelan sampah dikombinasikan dengan tanah lempung. Dari penelitian yang dilakukan, pemodelan dengan berbagai variasi hujan tidak terlalu berpengaruh terhadap penurunan faktor keamanan, sedangkan penggunaan geotekstil dan kombinasi dengan tanah lempung dapat menaikan nilai faktor keamanan
Modelling Power Consumption in IEEE 802.16e WiMAX Mobile Nodes

Energy availability is the main delimiter for usage time of mobile devices. As wireless network interfaces are usually the most power-demanding subsystem in a mobile device, mechanisms for their power consumption optimization are extensively researched. However, determining the power saving gains from using such optimizations is not an easy task, specially for simulation-based analysis. This work presents an extended power consumption model for the WiMAX interface in Mobile Nodes (MN), capable of capturing minimal contributions such as signalling overhead or burst allocation geometry. Simulation results show an effectiveness comparison of discussed power consumption models.
TEACHER PERCEPTION OF HANDHELD TECHNOLOGY: PEDAGOGICAL PRACTICES

ABSTRACT Many children already have access to a number of handheld and mobile devices for private use. However, this mobile trend does not appear to be reflected in the school. There are many barriers and triggers for such use, and in this paper we focus on the teacher’s perception of mobile technology and its affordances for pedagogical practices and activities in the classroom. We emphasise the relationship between teacher’s perception and pedagogical practices as seen through on-task activies. This paper is based on classroom observations, informal conversations and interviews with teachers in two classroom settings, one in the US and one in Norway. We use a tools/signs dichotomy as a conceptualisation of how the teachers perceive how the mobile devices mediate the pedagogical practices. KEYWORDS Handheld devices, perception, pedagogical affordances, pedagogical classroom practice 1. INTRODUCTION Educational theorists have often emphasized the potential of handheld devices (PDAs) in the classroom. Promises that handheld technology provides a “1:1” device-to-student ratio and of flexible access to technology, which will help children construct knowledge throughout their daily activities (Norris et al., 2002; Soloway et al., 2001; Tatar et al., 2003; Vahey & Crawford, 2002). Soloway compares the handheld to “the pencil, paper, and calculator”, and argues that in the same way, computers must be within arm’s reach, in order to make a difference in the classroom – they must be “ready-at-hand” (Soloway et al., 2001). Studies of use on PDAs indicate the advantages of using personal and handheld technologies for students (Corlett et al., 2005). The Palm Education Pioneers Program (PEP) reports that 85% of the teachers in the study believe that handhelds can improve the quality of learning activities and can have a positive effect on their teaching practices (Vahey & Crawford, 2002). They claim that handhelds were more easily integrated with the learning activities than desktop computers. Hennessy (2000) studied on students using a palmtop computer to record and graph weather data. She reports positive gains in motivation and that within the context of the activities undertaken, the handhelds were “instrumental in contributing to some learning gains” (p. 255). Sharples provides a account of a project at the University of Birmingham to develop a Handheld Learning Resource (HandLeR) that can assist people of all ages in their personal learning thought a lifetime (Sharples et al., 2002). The studies were based on interviews and questionnaires with 291 children aged 7-11 in 2 schools, designed to explore their learning habits and the likes and dislike of computers and learning technology. Informal interviews were also carried out with the teachers. Sharples reports that the children preferred to work in a group, but preferred to keep their products of their own work private. The findings suggest that personal technology should support group work whilst enabling children to own the results, and
Nonlinear mapping between continuous- and discrete-time dynamics

Linear mapping is widely used in dynamic modeling and empirical data analysis, but it suffers from the serious shortcoming that it does not work in the common case of time intervals being large. The fundamental cause of the failure is that the linear mapping does not take into account the coupling effects of multiple events within a discrete time interval. Here, we develop a theoretical framework to provide a nonlinear mapping between continuous- and discrete-time dynamics by accounting for the coupling effect. We have verified the effectiveness of our mapping by exploring classical susceptible-infected-susceptible and susceptible-infected-recovered models. In particular, we give a quantitative criterion that the sum of two transition probabilities —from one state to the other and vice versa— must be strictly less than 1 for binary-state dynamics.
4. On a Mechanical Theory of Thermo-Electric Currents

It was discovered by Peltier that heat is absorbed at a surface of contact of bismuth and antimony in a compound metallic conductor, when electricity traverses it from the bismuth to the antimony, and that heat is generated when electricity traverses it in the contrary direction. This fact, taken in connection with Joule's law of the electrical generation of heat in a homogeneous metallic conductor, suggests the following assumption, which is the foundation of the theory at present laid before the Royal Society.
On the Role of Institutional Logics in Legitimacy Evaluations: The Effects of Pricing and CSR Signals on Organizational Legitimacy

The relationship between institutional logics and organizational legitimacy remains largely unaddressed in organizational theory and management research. We explore how individual evaluators primed with a particular institutional logic react to organizational signals sent by a firm's product/service pricing and by its engagement in corporate social responsibility (CSR) activities. In three experimental studies, we identify how the activation of a market logic or a family logic in evaluators’ minds moderates the effect of pricing and CSR engagement signals on their judgments of legitimacy of a firm, as well as on their behavioral intentions. An unexpected finding from our study was that, while participants primed with the family logic reacted positively to a CSR engagement signal sent by the firm but remained indifferent to a market-based premium-pricing signal, those primed with the market logic reacted positively to both premium-pricing and CSR engagement signals, suggesting that CSR engagement forms part of their understanding of the market logic.
Assessment of anaerobic biodegradability

Present study was carried out to evaluate biodegradability of industrial effluent (high strength waste water from organic chemical industry) to reduce organic load (BOD/COD). We used anaerobic treatment by up-flow anaerobic sludge blanket (UASB) in three modes stepwise namely; one time feed reactor, daily batch type feed reactor and daily continuous feed reactor. A laboratory scale anaerobic system contains feed tank, UASB reactor bottle and gas collection bottle. A UASB bioreactor was made up of glass bottle with digester volume 8 liters, organic loading rate in daily batch type feed reactor was 2gms/day/lit and organic loading rate in daily continuous feed reactor was 5gms/day/lit. The results indicated that the COD removal efficiency of one time feed reactor was 53%, daily batch feed reactor was 66.19% and daily continuous feed reactor was 62.16%. Depending upon the result obtained it can be concluded that effluent under study can be treated by anaerobic biological treatment (followed by 2 stage ASP + nitrification & de-nitrification + RO). Biogas produced contains less amount of methane and higher amount of nitrogen gas therefore; biogas generated under present study couldn't be used as fuel source.
Towards interoperable information and communication systems for manufacturing operations

Mass customization and the demand for flexible manufacturing systems have increase focus on the human workers. Diversity and complexity of the products that manufacturing operators have to handle is constantly on the rise. It is believed that the recent advances in information and communication technology can assist the manufacturing organisations to manage these challenges. As a matter of fact, if organisations manage to implement the systems correctly, the productivity is thought to increase to such an extent that it will give rise to a new paradigm in production, the fourth industrial revolution. However, as it stands now, there is a large gap between the exiting technology and what is actually used in the manufacturing industry. If organisations are to close this gap they need to manage several challenges. The problem addressed in this thesis is how to design and structure the information and communication systems that need to handle the new technologies, and particularly those designed for manufacturing operators and the automation systems. This thesis aims to aid the manufacturing operations organisations to configure their information and communication systems and this has been done regarding interoperability. Interoperability is the ability for systems to communicate and exchange data which is crucial to enable many different systems to co-exist and work together. The information and communication technologies that manufacturing operators use have been connected with several areas of interoperability research, which enable a useful discussion about the implementation and design choices of the technology.
Performance Analysis of Orthogonal Gradient Sign Algorithm Using Spline-based Hammerstein Model for Smart Application

This paper presents a spline-based Hammerstein model for adaptive filtering based on a sign algorithm with the normalised orthogonal gradient algorithm. Spline-based Hammerstein architecture consists of an interpolation spline-based adaptive lookup table in the part of nonlinear filter and an adaptive finite impulse response filter used in the part of linear filter. Hammerstein spline adaptive filter (HSAF) is a nonlinear filter for the nonlinear systems among the advantages in the low computational cost and high performance. An adaptive lookup table and spline control points are determined and derived with the orthogonal gradient-based mechanism. Performance analysis in terms of convergence properties and mean square analysis based on the mean square error (MSE) constraint are proven by using the Taylor series expansion of the estimation error in the form of the excess MSE. Experimental results indicate the robust performance of the proposed algorithm can provide the better performance than the other models based on the conventional least mean square Hammerstein spline adaptive filtering algorithm.
Mapping Canopy Cover in African Dry Forests from the Combined Use of Sentinel-1 and Sentinel-2 Data: Application to Tanzania for the Year 2018

High-resolution Earth observation data is routinely used to monitor tropical forests. However, the seasonality and openness of the canopy of dry tropical forests remains a challenge for optical sensors. In this study, we demonstrate the potential of combining Sentinel-1 (S1) SAR and Sentinel-2 (S2) optical sensors in order to map the tree cover in East Africa. The overall methodology consists of: (i) the generation of S1 and S2 layers, (ii) the collection of an expert-based training/validation dataset and (iii) the classification of the satellite data. Three different classification workflows, together with different approaches to incorporating the spatial information to train the classifiers, are explored. Two types of maps were derived from these mapping approaches over Tanzania: (i) binary tree cover–no tree cover (TC/NTC) maps, and (ii) maps of the canopy cover classes. The overall accuracy of the maps is >95% for the TC/NTC maps and >85% for the forest types maps. Considering the neighboring pixels for training the classification improved the mapping of the areas that are covered by 1–10% tree cover. The study relied on open data and publicly available tools and can be integrated into national monitoring systems.
The Emerging Role of E3 Ubiquitin Ligase SMURF2 in the Regulation of Transcriptional Co-Repressor KAP1 in Untransformed and Cancer Cells and Tissues

Simple Summary KAP1 plays an essential role in different molecular and cellular processes central to carcinogenesis, disease progression, and treatment response, revealing both tumor promoting and anticancer functions. The mechanisms that control the steady-state levels of KAP1 and its protein abundance are not well known. Our findings show that SMURF2, a ubiquitously-expressed HECT-type E3 ubiquitin ligase with suggested anticancer activities, is capable to directly bind, ubiquitinate, and regulate KAP1 expression levels in non-cancerous and tumor cells and tissues. The data further show that SMURF2 has a significant influence on KAP1 interactome, regulating its protein–protein interactions and functions in a catalytically-dependent manner. These findings reveal SMURF2 as a pivotal regulator of KAP1, laying a foundation for the investigation of the role of the SMURF2–KAP1 axis in carcinogenic processes and therapeutic responses to anticancer treatment. Abstract KAP1 is an essential nuclear factor acting as a scaffold for protein complexes repressing transcription. KAP1 plays fundamental role in normal and cancer cell biology, affecting cell proliferation, DNA damage response, genome integrity maintenance, migration and invasion, as well as anti-viral and immune response. Despite the foregoing, the mechanisms regulating KAP1 cellular abundance are poorly understood. In this study, we identified the E3 ubiquitin ligase SMURF2 as an important regulator of KAP1. We show that SMURF2 directly interacts with KAP1 and ubiquitinates it in vitro and in the cellular environment in a catalytically-dependent manner. Interestingly, while in the examined untransformed cells, SMURF2 mostly exerted a negative impact on KAP1 expression, a phenomenon that was also monitored in certain Smurf2-ablated mouse tissues, in tumor cells SMURF2 stabilized KAP1. This stabilization relied on the unaltered E3 ubiquitin ligase function of SMURF2. Further investigations showed that SMURF2 regulates KAP1 post-translationally, interfering with its proteasomal degradation. The conducted immunohistochemical studies showed that the reciprocal relationship between the expression of SMURF2 and KAP1 also exists in human normal and breast cancer tissues and suggested that this relationship may be disrupted by the carcinogenic process. Finally, through stratifying KAP1 interactome in cells expressing either SMURF2 wild-type or its E3 ligase-dead form, we demonstrate that SMURF2 has a profound impact on KAP1 protein–protein interactions and the associated functions, adding an additional layer in the SMURF2-mediated regulation of KAP1. Cumulatively, these findings uncover SMURF2 as a novel regulator of KAP1, governing its protein expression, interactions, and functions.