Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular results and potential biomarkers identified from MILO/ENGOT-ov11 phase 3 study of binimetinib versus physicians choice of chemotherapy (PCC) in recurrent low-grade serous ovarian cancer (LGSOC).

5519 Background: Lower responses to chemotherapy and the unique molecular profile of LGSO led to the adoption of MEK-inhibitors for this disease. Updated analysis from the MILO/ENGOT-ov11 phase III study of binimetinib vs PCC in recurrent LGSOC showed response rate of 24% in those treated with binimetinib (JCO, 2020; NCT01849874). Here we present results of the post-hoc tumor tissue biomarker analysis performed with MILO/ENGOT-ov11. Methods: Mutational/copy number analysis was performed via Foundation Medicine on archival tissue obtained prior to randomization. Unbiased univariate analysis was used to test association between mutation status and outcomes in binimetinib and PCC treated patients. Outcomes examined were progression free survival (PFS), binary response by local RECIST 1.1 (complete or partial response [CR/PR] vs. stable [SD] or progressive disease [PD]), and ordinal response. Kaplan-Meier was used to estimate PFS. Cox regression, binary logistic regression, and ordinal logistic regression were used to examine relationship between mutation status and outcomes. Results: MILO/ENGOT-OV11 enrolled 341 patients from June, 2013 to April, 2016. Patients were randomized 2:1 to binimetinib or PCC. Based on January 1, 2020 data cut-off the data is as-is, amongst those patients treated with binimetinib with molecular results available, PFS data is available for 144 and response rate (RR) data for 135. There were 47 mutations detected in ≥5% of patients, most commonly KRAS (33%). Patients harboring a KRAS mutation had 3.4 times the odds of responding to treatment with binimetinib as patients without KRAS mutation (95% CI 1.57,7.67; p-value 0.002). There was no difference in effect of KRAS G12V mutation vs other KRAS mutation on PFS (PFS HR 1.06; 95% CI:0.53, 2.12; p value 0.9). In the 135 patients with binimetinib RR data, other MAPK mutations were identified as follows; NRAS in 11(8.1%), BRAFV600E in 8(5.9%), RAF1 in 2 (1.5%), NF1 in 7 (5.2%). In patients with MAPK mutation (as defined above) the RR was 41% vs 13% in those without MAPK mutation. PFS was significantly better in patients treated with binimetinib harboring MAPK mutation vs those without (HR 0.5; 95% CI 0.31, 0.79; p = 0.003). In patients treated with PCC there was a nonsignificant trend towards improved PFS in those with MAPK mutation vs those without (HR 0.82; 95% CI 0.43,1.59; p = 0.6). A test for interaction between treatment and MAPK pathway was not significant by Cox regression model (p = 0.32). Conclusions: While this hypothesis generating analysis is limited by multiple testing, higher response rates and longer PFS were seen in those patients with LGSOC treated with binimetinib who harbored MAPK mutations, most commonly in KRAS. Somatic tumor testing should be routinely performed in patients with recurrent LGSOC to aid in clinical decision making. Clinical trial information: NCT01849874.
An Ethnomethodological Study of Abductive Reasoning While Tinkering

Tinkering is often viewed as arbitrary practice that should be avoided. However, tinkering can be performed as part of a sound reasoning process. In this ethnomethodological study, we investigated tinkering as a reasoning process that construes logical inferences. This is a new asset-based approach that can be applied in computer science education. We analyzed artifact-based interviews, video observations, reflections, and scaffolding entries from three pairs of early childhood teacher candidates to document how they engaged in reasoning while tinkering. Abductive reasoning observed during tinkering is discussed in detail.
Application of chemical compounds during pre-harvesting to control post-harvesting green mold in citrus

This study aimed to evaluate the effect of system-acquired resistance inducing compounds applied during the pre-harvest of ‘Navelina’ orange and ‘Ortanique’ tangor in controlling post-harvest disease caused by Penicillium digitatum. The products applied were acibenzolar-s-methyl (ASM), imidacloprid (IMI), methyl jasmonate (MeJa), sodium selenite, potassium silicate, and thiamethoxam (TMT). Sterile distilled water was used as the control. The applications were administered 45, 30, and 15 days before harvesting. In 2015 and 2016, 840 fruits were randomly collected, and when they reached commercial maturation, they were sanitized, half were pierced with a needle in the equatorial region. The fruits were inoculated with a 10 μL spore suspension (1 × 106 conidia mL-1) of P. digitatum, in the equatorial region. The experiment was performed with three replicates, each comprising 10 fruits and repeated over two consecutive crop seasons. Disease incidence was evaluated on pierced (at 72 and 144 h after inoculation [hai]) and unperforated (at 360 hai) fruits. For pierced fruits, lesion expansion rate (rL), disease severity, expansion rate of sporulating area (rE), and sporulating area were evaluated. The area under the disease progress curve (AUDPC) and the area under the sporulating area progress curve were calculated. Both cultivars were susceptible; however, the rL and rE had lower values for ‘Ortanique’. The tested products reduced the disease incidence in both cultivars. Potassium silicate reduced rL and rE, whereas sodium selenite reduced rE. The disease severity was reduced by potassium silicate, sodium selenite, and ASM. AUDPC was reduced by sodium selenite and potassium silicate treatments. Among the tested products, potassium silicate and sodium selenite applied during the pre-harvest of ‘Navelina’ orange and ‘Ortanique’ tangor had the highest reductions for disease incidence (ranging from 14% to 37%, respectively) and severity (60% and 70%, respectively), rE (50% for both compounds), and total sporulating area (55% and 56%, respectively), reducing the green mold in postharvested fruits caused by P. digitatum.
Consensus disease definitions for the spectrum of neurologic immune related adverse events.

2647 Background: Expanding FDA-approved indications for immune checkpoint inhibitors in patients with cancer has resulted in both therapeutic success and immune related adverse events (irAEs). Neurologic irAEs (irAE-Ns) have an incidence of 1-12% and a high fatality rate relative to other irAEs. Lack of standardized disease definitions and accurate phenotyping leads to syndrome misclassification and impedes evidence-based treatments and research progress. The objectives of this study were to develop consensus guidance for an approach to irAE-Ns including disease definitions and severity grading. Methods: A working group of 4 neurologists drafted irAE-N consensus guidance and definitions, which were reviewed by the Neuro irAE Disease Definition Panel, consisting of neurologists, oncologists, neuro-oncologists and irAE subspecialists. A modified Delphi consensus process was used, with 2 rounds of anonymous ratings by panelists and 2 virtual meetings to discuss areas of controversy. Panelists rated content for usability, appropriateness and accuracy on 9-point scales in electronic surveys and provided free text comments. The working group aggregated survey responses and incorporated them into revised definitions. Consensus was based on numeric ratings using the RAND/UCLA Appropriateness Method with prespecified definitions. Results: Twenty-seven panelists from 15 academic medical centers voted on a total of 53 rating scales (6 general guidance, 24 central and 18 peripheral nervous system disease definition components, 3 severity criteria and 2 clinical trial adjudication statements); of these, 77% (41/53) received first round consensus. After revisions, all items received second round consensus. Consensus definitions were achieved for 7 core disorders: irMeningitis, irEncephalitis/Encephalomyelitis, irDemyelinating disease, irVasculitis, irNeuropathy, irNeuromuscular junction disorders and irMyopathy. For each disorder, 6 sub-classifications are described: disease subtype, diagnostic certainty, severity, autoantibody association, exacerbation of pre-existing disease or de novo presentation and present or absent concurrent irAE. Conclusions: These disease definitions standardize irAE-N classification. They are being incorporated into a multi-institutional registry that our group has initiated to study irAEs. Given consensus on their accuracy and usability from a representative panel group, we anticipate that they can be used broadly across clinical and research settings.
IPTU PARTICIPATIVO E INTERNET PARA OS CIDADÃOS: PROJETO DE CIDADE DIGITAL DE ENGENHEIRO BELTRÃO – PARANÁ, BRASIL

Conscientizar o cidadão quanto à importância do pagamento de impostos e envolvê-lo no processo de decisão quanto aos investimentos que considera prioritários na sua cidade não se demonstra tarefa fácil. Poucos municípios brasileiros conseguem utilizar de maneira adequada os instrumentos de gestão que têm disponíveis, e neste viés, o Imposto Predial e Territorial Urbano (IPTU) se constitui uma das principais fontes de arrecadação tendo uma função social, principalmente, quando se trata de uma adequada política de desenvolvimento urbano. O objetivo é analisar o projeto de “cidade digital”, intitulado EbOnline, de Engenheiro Beltrão, no Estado do Paraná e a contribuição do IPTU participativo para a existência do projeto. O método da pesquisa é um estudo de caso, e as técnicas realizam análises qualitativas de informações extraídas de documentos da Prefeitura e questionamento via e-Sic ao quadro técnico de servidores. Os resultados auferidos demonstram que é possível aplicar os recursos orçamentários de acordo com a opinião da população, pois o dinheiro arrecadado com o IPTU foi revertido em sinal de internet, gratuita, para os cidadãos, possibilitando à cidade ser reconhecida como digital. A conclusão traz que a participação popular, como um método inovador de se fazer a gestão urbana, pode ser uma realidade desde que se desenhem estratégias capazes de aumentar e incentivar a participação social, assim como propiciar o atendimento ao anseio dos cidadãos, contribuindo assim com a melhoria da qualidade de vida daqueles que habitam as cidades, como foi o caso do projeto de cidade digital de Engenheiro Beltrão.
Tailoring Morphology and Structure of Inkjet‐Printed Liquid‐Crystalline Semiconductor/Insulating Polymer Blends for High‐Stability Organic Transistors

Inkjet printing of semiconducting polymers is desirable for realizing low‐cost, large‐area printed electronics. However, sequential inkjet printing methods often suffer from nozzle clogging because the solubility of semiconducting polymers in organic solvents is limited. Here, it is demonstrated that the addition of an insulating polymer to a semiconducting polymer ink greatly enhances the solubility and stability of the ink, leading to the stable ejection of ink droplets. This bicomponent blend comprising a liquid‐crystalline semiconducting copolymer, poly(didodecylquaterthiophene‐alt‐didodecylbithiazole) (PQTBTz‐C12), and an insulating commodity polymer, polystyrene, is extremely useful as a semiconducting layer in organic field‐effect transistors (OFETs), providing fine control over the phase‐separated morphology and structure of the inkjet‐printed film. Tailoring the solubility‐induced phase separation of the two components leads to a bilayer structure consisting of a polystyrene layer on the top and a highly crystalline PQTBTz‐C12 layer on the bottom. The blend film is used as the semiconducting layer in OFETs, reducing the semiconductor content to several tens of pictograms in a single device without degrading the device performance. Furthermore, OFETs based on the PQTBTz‐C12/polystyrene film exhibit much greater environmental and electrical stabilities compared to the films prepared from homo PQTBTz‐C12, mainly due to the self‐encapsulated structure of the blend film.
Impact of Smoking on Lifestyle and Vitality in College Students

There is a long history of studies on the bad influence of smoking on our bodies, with many study results accumulated to date indicating a decline in the smoking rate. However, the smoking rate in Japan is still higher than that in other countries. In order to reveal the various influences due to smoking, we examined the changes in lifestyle and vitality prior to and the following smoking, targeting college students who are at the early age of starting to smoke. The subjects were 213 college students (83 men and 130 women). Smoking frequency as well as sleeping, eating habits, exercise, and vitality as a lifestyle were surveyed through a questionnaire survey. As a result of comparing smoking and lifestyle between the smoking group and non-smoking group, in terms of sleep, the bedtime and wake-up time tended to be late in the smoking group. Regarding eating habits, there was a tendency for the smoking group to have a high rate of skipping breakfast and a high intake rate of midnight snacks. Regarding exercise, the number of people exercising on a daily basis was small in both the smoking group and the non-smoking group, with no significant difference observed. Therefore, this study revealed that smoking has a negative influence on some aspects of lifestyle. There was no significant relationship in terms of the effects of smoking on vitality. Going forward, it will be necessary to clarify the negative effects of smoking on mental health.
A Cognitive Linguistics Study to Reveal the Concept of Death of Indonesian Indigenous Tribe

Despite of many previous studies related to conceptual metaphor have been conducted since George Lakoff and Mark Johnson have introduced their work known as Metaphor We Live By in 1980, but none of them have analysed oral discourse as their corpus. This study aims to reveal the concept of death belonging to one of the Indonesian indigenous tribes located in Sulawesi Island called Kajang tribe. The Kajang tribe has an ancient oral discourse which delivers orally from generation to generation known as Pasang ri Kajang, and it is full of metaphorical expressions. This present study employs the conceptual metaphor theory (CMT) introduced by Lakoff and Johnson (1980, 2003), and the approach of conceptual metaphor analysis (CMA) by Charteris Black (2004) to reveal the concept of death found in Pasang ri Kajang. This qualitative research obtained the data through semi-structured interviews, field observation, recording, and note-taking. The conceptual metaphor techniques comprising three CMA stages, namely identification, interpretation, and explanation, were used for data analysis. The results of the study indicate that the concept of death as found in Pasang ri Kajang is DEATH IS A JOURNEY. This conceptual metaphor gives a detailed description of death as a journey of the soul to the hereafter. This research concludes that people of Kajang believes only good souls are rewarded with eternal life (Karakkang) and extraordinary wealth (Kalumannyang kaluppepeang) in the hereafter (ahera).
Independent validation of simbiosys tumorscope to predict response to neoadjuvant chemotherapy (NACT) in early breast cancer (EBC).

582 Background: Despite substantial advances in the understanding of breast cancer biology, the decision to use NACT for EBC is based on tumor size, lymph node status, and subtype. Even with aggressive therapy, the majority of women will not achieve a pathologic complete response (pCR). Investigational treatment regimens, including immunotherapy, can increase pCR rates, but are associated with irreversible immune-related toxicities. Being able to accurately predict pCR could identify candidates for intensification or de-escalation of NACT, allowing for personalized medicine. SimBioSys TumorScope (TS) is a biophysical model that utilizes baseline MRI, receptor status, and planned treatment regimen to simulate response to NACT over time. TS has demonstrated accurate prediction of pCR in prior studies. Here, we describe an independent external validation of TS. Methods: We conducted a retrospective study of University of Chicago patients (pts) who received NACT for EBC from Jan 2010 - March 2020. Pts must have had a pretreatment breast MRI. Tumors were analyzed using TS by investigators who were blinded to response data. TS predicted pCR was predefined as a residual tumor volume < 0.01 cm3 or a 99.9% or greater reduction in tumor volume. Performance metrics of TS were calculated. Results: 144 tumors from 141 pts were analyzed. Average age was 52 yrs; 65% had stage II and 19% had stage III disease. Sensitivity and specificity of TS for predicting pCR were 90.4% and 92.4%, respectively. Of the 7 patients who were predicted to achieve a pCR but did not, 5 had a tumor cellularity < 5%. With a median follow-up of 4.7 yrs, the 4-yr distant disease free survival (DDFS) was 100% for patients predicted to achieve pCR, versus 81.5% for those predicted to have residual disease. Results were generally robust for all subgroups analyzed (Table). Conclusions: TS accurately predicts pCR and DDFS from baseline MRI and clinicopathologic data. Given the high sensitivity and specificity of this assay across breast cancer subtypes, TS can be used to aid in escalation/de-escalation strategies for EBC. [Table: see text]
Threat Modelling and Beyond-Novel Approaches to Cyber Secure the Smart Energy System

Smart Grids (SGs) represent electrical power systems that incorporate increased information processing and efficient technological solutions. The integration of local prosumers, demand response systems and storage allows novel possibilities with regard to energy balancing and optimization of grid operations. Unfortunately, the dependence on IT leaves the SG exposed to security violations. In this paper, we contribute to this challenge and provide a methodology for systematic risk assessment of cyber attacks in SG systems. We propose a threat model and identify possible vulnerabilities in low-voltage distribution grids. Then, we calculate exploitation probabilities from realistic attack scenarios. Lastly, we apply formal verification to check the stochastic model against attack properties. The obtained results provide insight into potential threats and the likeliness of successful attacks. We elaborate on the effects of a security violation with regard to security and privacy of energy clients. In the aftermath, we discuss future considerations for improving security in the critical energy sector.
Mass Spectrometry of Organoaluminum Derivatives

Mass spectrometry has been applied to the characterization of organoaluminum compounds in work that dates back to the introduction of the first commercial instruments. As new ionization methods and associated instrumentation were developed, they have been applied to more difficult analyses so as to characterize the compounds of increasingly higher molecular weight, low volatility and ionic organoaluminum compounds. In thifs chapter, practical advice for performing these analyses, and choice of ionization method(s) to be applied is provided, as well as a representative survey of the various mass spectrometric techniques that have been applied to analysis of organoaluminum compounds. Keywords: mass spectrometry; organoaluminum; electron ionization; chemical ionization; field desorption; electrospray ionization; fast atom bombardment; liquid secondary ion; matrix-assisted laser desorption; direct analysis in real time
Adaptive neural output-feedback control for a class of output-constrained switched stochastic nonlinear systems

In this paper, a neural network-based adaptive output-feedback control problem is investigated for a class of output-constrained switched stochastic nonlinear systems. By introducing nonlinear mapping, the asymmetric and symmetric output constrained stochastic nonlinear system is transformed into a new system without any constraint. It is the first time that a switching system is used to convert symmetric and asymmetric output constraints in the same system. An adaptive neural output-feedback controller is developed based on the backstepping technique. A state observer is designed to estimate the unmeasurable system state signals. An adaptive controller is designed to ensure that the output tracking error converges to a small region of the origin. The control scheme ensures that all signals in the closed-loop systems are semi-global uniformly ultimately bounded. Results of simulation cases are presented to prove the effectiveness of the theoretical analysis.
Phenol removal by newly isolated Acinetobacter baumannii strain Serdang 1 in a packed-bed column reactor

AbstractA newly isolated Acinetobacter baumannii strain Serdang 1 was explored for its potential in phenol remediation in batch and continuous system. An immobilization cell system has been successfully developed to remove phenol in a batch system as high as 2,000 mg/L in 12 d at a rate of 6.04 mg/L/h. Repeated use of immobilized cells as many as five cycles was shown without any loss of activity. The continuous system in a packed-bed reactor achieved 65–77% phenol removal at the rate of 38.4 mg/L/h for 200 mg/L influent, which was almost three fold higher than the batch system. Low influent flow rate at 1.5 mL/min and bed height-to-diameter ratio of 15.2 reached steady state faster than the higher flow rate, and the percentage of phenol removal was also higher.
¡Pide mi vino!: análisis con eye tracking del etiquetado de botellas de vino en una feria nacional del vino

En una sociedad saturada e hipercomunicada, un diseno eficaz es clave para el exito de un producto. Las tecnicas neurocientificas al servicio de la publicidad y el marketing constituyen herramientas efectivas a la hora de predecir el comportamiento del consumidor. Teniendo en cuenta este contexto y la gran diversidad de vinos que se comercializan en el mercado espanol, se pretende analizar el etiquetado de una seleccion de marcas y envases de vino. El objetivo principal de la investigacion fue demostrar a las bodegas participantes cuales eran las zonas de sus etiquetados en los envases que despertaban mayor interes o engagementcon su publico objetivo. El estudio emplea un Eye Tracker de sobremesa y se desarrollo en la feria nacional de vino (FENAVIN) celebrada en Ciudad Real (Castilla La-Mancha) en 2019. La muestra objeto de analisis esta integrada por especialistas del sector asistentes a la feria. Los resultados demostraron que las zonas superiores y centrales del etiquetado despertaban mayor interes, identificando las areas ciegas que no reciben atencion por parte de los sujetos analizados. El estudio concluye que el grado de atractivo y originalidad en el diseno de las etiquetas son factores determinantes clave en los procesos de percepcion y la seleccion de los consumidores.