Miracle-dz/UniFAR-FTUs huggingface dataset:
Uji Mutu Fisik Metoklopramid HCl Tablet Chewable dengan Variasi Jenis Pengisi sebagai Diluent menggunakan Metode Granulasi Basah

Metoclopramide HCl are used to reduce vomiting and nausea. The availability on the market in the form of tablet, syrup and injection. Patient tend to prefer take drugs by oral use because it was easier. Chewable tablet is the new product as the alternative ways to treatment children and adult patient who had difficulity problem of swallowing drugs. Objectives: This research aims to formulate the chewable metoclopramide HCl tablets using diluent variations to get a better physical quality test. Chewable tablets of metoclopramide HCl are made using diluent variations, they are mannitol, sucrose, lactose. Formula I mannitol, formula II sucrose, and formula III lactose. Chewable tablet preparations are made by the wet granulation method. Data collection was performed on physical characteristics including organoleptic, weight uniformity, uniformity of size, tablet hardness, tablet fragility, disintegration time, metoclopramide HCl levels. Physical quality test results were statistically analyzed to determine the effect of variations in the diluent on the characteristics of chewable tablets. The results of this research have an influence on the physical quality and uniformity of contents of various types of diluent variations between each formulation. In this research, fillers have an important role in the preparation of chewable metoclopramide tablets to determine the physical quality of the tablets and the uniformity of their contents. The variation of diluent that gives better results is mannitol. This is because formulas that use mannitol have uniformity in content that meets the requirements, faster disintegration time, and physical quality of tablets that still meet the requirements, when compared to the first and second formulations. The variation of diluent that gives better results is mannitol.
Post-Concussion Syndrome and Factors Associated With Post- Concussion Syndrome Following Mild Traumatic Brain Injury

Background: Traumatic Brain Injury (TBI) is a worldwide public health concern especially in developingcountries. This study was conducted to describe the prevalence, severity symptoms and determine factorsassociated with post-concussion syndrome (PCS) following mild traumatic brain injury (MTBI). Methods: A cross-sectional study was carried out with 218 patients following MTBI after dischargedhospital from one week to one year at Odor Meanchey Provincial Hospital (OMCPH) and Anlong VengReferral Hospital (AVRH). Multiple linear regression was applied to determine factors association.Results: Of the total 218 patients following MTBI, 79.4% had symptoms of PCS, with 5.8% re-hospitalizationdue to PCS. The most frequently occurring symptoms in PCS following MTBI were from headache 71.7%,being irritable 68.8%, forgetfulness 66.5%, fatigue 62.4%, and taking longer to think 57.2%. Marital statuss=-. 236, p=. 001, loss of consciousness (LoC) at the time of injury s=-. 205, p=. 003, length of hospitalizations=. 288, p<0.001, and readmission s=-. 271, p<0.001 were statistically associated with PCS following MTBI.Conclusion: Majority of patients had symptoms of PCS. The most frequent symptoms were headache, beingirritable, and forgetfulness. Socio-demographic and injury characteristics factors play an essential role inPCS following MTBI.
User Participation Behavior in Crowdsourcing Platforms: Impact of Information Signaling Theory

As a type of open innovation, emerging crowdsourcing platforms have garnered significant attention from users and companies. This study aims to determine how online seeker signals affect the user participation behavior of the solver in the open innovation crowdsourcing community, by means of which to achieve the long-term sustainable development of the emerging crowdsourcing platform. We performed data analysis based on the system of regression equation approach in order to conduct quantitative research. We found that online reputation and salary comparison positively influence user participation behavior, and that interpersonal trust acts as a strong mediator in the relationship between salary comparison and user participation behavior. In addition, we observed an elevation in task information diversification as a moderator, which positively affects online seeker signals on user participation behavior. Furthermore, an upsurge was noted in task information overload as a moderator, which adversely affects online seeker signals on user participation behavior. The contributions of this article include the application of the innovative signal transmission model, and online task information quality has important guiding significance on how to design task descriptions for emerging crowdsourcing platforms in order to stimulate user participation behavior.
Cytotoxicity and Bioremediation of Heavy Metals by Highly Resistant Marine Bacteria

Environmental pollution of heavy metals is increasingly becoming a problem and has become of great concern due to the adverse effects it is causing around the world. These inorganic pollutants are being discarded in our waters, soils and into the atmosphere due to the rapidly growing agriculture and metal industries, improper waste disposal, fertilizers, and pesticides. Pollution in industrial areas is a serious environmental concern. Wastewater containing biotoxic substances of heavy metals in the ecosystem is one of the most important environmental and health challenges in our society. Hence, there is a growing need for the development of novel, efficient, eco-friendly, and cost-effective approach for the remediation of inorganic metals (Cr, Hg, Cd, and Pb) released into the environment and to safeguard the ecosystem. Mercury (Hg), Chromium (Cr), Cadmium (Cd), Review Article Danial et al.; JABB, 24(4): 48-72, 2021; Article no.JABB. 68532 49 and lead (Pb) are known to cause damage to living organisms, including human beings. In this regard, recent advances in microbes-base heavy metal have propelled bioremediation as a prospective alternative to conventional techniques. Heavy metals are nonbiodegradable and could be toxic to microbes. Several microorganisms have evolved to develop detoxification mechanisms to counter the toxic effects of these inorganic metals. Several marine bacteria highly resistant and capable of growing at higher concentrations of Hg, Cr, Cd and Pb and to evaluate their potential to detoxify. Their detoxification efficiency for Hg, Cr, Cd and Pb indicates good potential for application in bioremediation of toxic heavy metals.
Green synthesis of selenium nanoparticle by Abelmoschus esculentus extract and assessment of its antibacterial activity

ABSTRACT Green synthesis of selenium nanoparticles (Se-NPs) was done using Abelmoschus esculentus extract as the capping and reducing agent and sodium selenite (Na2SeO3) as the selenium source. UV-Vis spectrum confirmed the formation of Se-NPs in the solution. According to the XRD pattern, the average particle size was estimated to be about 30.7 nm. The TEM images shown the spherical shape of Se-NPs. The antimycobacterial effects of Se-NPs were tested against the standard strains of Mycobacterium tuberculosis (H37RV) and Mycobacterium simiae isolates. Antibacterial impacts were examined through the usage of resazurin microtiter assay (REMA) against bacterial strains, including Staphylococcus aureus, Streptococcus mutans, Escherichia coli, and Pseudomonas aeruginosa. There were no significant abilities to be reported from the Se-NPs for combating M. tuberculosis H37Rv and M. simiae strains. Based on the results, the nanoparticles displayed stronger antibacterial activities towards the Gram-positive bacteria.
Controls on Nutrient Cycling in Estuarine Mangrove Lake Sediments

We estimated the net exchange of nitrogen and phosphorus species using core incubations under light and dark conditions in estuarine lakes that are the aquatic interface between the freshwater Everglades and marine Florida Bay. These lakes and adjacent shallow water Florida Bay environments are sites where the restoration of hydrological flows will likely have the largest impact on salinity. Sediment respiration, measured by oxygen uptake, averaged (±S.D.) −2400 ± 1300, −300 ± 1000, and 1900 ± 1400 μmol m−2 h−1 for dark incubations, light incubations, and gross photosynthesis estimates, respectively, with dark incubations consistent with oxygen uptake measured by microelectrode profiles. Although most fluxes of soluble reactive phosphorus, nitrate, and N2–N were low under both light and dark incubation conditions, we observed a number of very high efflux events of NH4+ during dark incubations. A significant decrease in NH4+flux was observed in the light. The largest differences between light and dark effluxes of NH4+ occurred in lakes during periods of low coverage of the aquatic macrophyte Chara hornemannii Wallman, with NH4+ effluxes > 200 μmol m−2 h−1. Increasing freshwater flow from the Everglades is expected to expand lower salinity environments suitable for Chara, and therefore, diminish the sediment NH4+ effluxes that may fuel algal blooms.
Specialized High-Quality 16S Ribosomal RNA Gene Databases for Identification of Bacterial Taxonomic Groups: a review

Recent accumulation of the bacterial 16S and 23S rRNA gene sequences in the public GenBank databases obtained from the wide use of the Polymerase Chain Reaction (PCR) and the Next Generation Sequencing (NGS) applications has led the specialists in the fields of microbiology and bioinformatics to provide specific and reliable databases for storing, retrieving and aligning bacterial ribosomal gene sequences. In our review, we have provided a comprehensive description of gene databases with an emphasis on the most specialized and high quality rRNA gene databases. These databases are freely accessible and widely used for all specialist users for accurate bacterial genera and species identification from different sources. rRNA genes, platforms, internet addresses and references of each gene specialized database were outlined. The Silva, EzTaxon-e and BIBI have been shown to be the most confident and reliable specialized rRNA gene databases. These databases contain the semi fully high-quality ribosomal gene sequences along with some house-keeping and uncultured gene sequences in case of EzTaxon-e.
Derivation of soil moisture retention characteristics from saturated hydraulic conductivity

Knowledge of the physics of soil water movement is crucial to the solution of many problems in watershed hydrology, for example, the prediction of run-off and infiltration following precipitation, the subsequent distribution of infiltrated water by drainage and evaporation, and estimation of the contribution of various parts of a watershed to the ground water storage. Mathematical models of hydrologic and agricultural systems require knowledge of the relationships between soil moisture content (θ), soil water pressure (h) and unsaturated hydraulic conductivity (K). Sustained research effort towards the parameterisation of K(h) and h(θ) has resulted in the development of several laboratory, field and theoretical methods. This study involved field and laboratory determination of soil moisture characteristics along the Hindon river in its upstream reach. The soils in this area are mainly sand, loamy sand, sandy loam and silt loam. A total of 37 soil samples were collected from 13 sites in 24 km upstream reach of Hindon river. Extensive laboratory measurements were made for each soil sample. Saturated hydraulic conductivity was measured through ICW Permeameter in the laboratory. Retention curve data were obtained through pressure plate apparatus. These have been used to develop an empirical relationship to derive the approximate soil moisture retention curve at the places in upper part of Hindon river basin where only saturated hydraulic conductivity data are available.
Successful treatment of an EBV‐positive HIV‐associated polymorphic B‐cell lymphoproliferative disorder by rituximab monotherapy

Dear Editor, The incidence of lymphoproliferative disorders (LPDs) is significantly increased in immunocompromisedpopulations, includinghuman immunodeficiency virus (HIV)-infected patients and solid organ or hematopoietic stem cell transplantation recipients. The majority of HIV-related lymphomas are clinically aggressive, high-grade monoclonal B-cell lymphomas. In contrast, post-transplantation lymphoproliferative disorders (PTLD) represent a heterogeneous group of lesions as PTLD consisted in either polymorphic or monomorphic proliferation that could be polyclonal, oligoclonal or monoclonal, while the vast majority is ofB-cell origin anddriven inhalf of the casesbyEpstein-Barr virus (EBV) [1]. EBV-associated polymorphic B-cell LPD resembling polymorphic PTLD is a rare but recognized complication of HIV [2]. However, less than 20 cases have been published in the literature, and data regarding their treatment and outcomes are extremely scarce. We describe here a 36-year-old male HIV-infected patient treated for more than 10 years by highly active antiretroviral therapy (HAART) with sustained viremic control and no history of opportunistic infection. He was hospitalized in our institution for acute and invalidating abdominal pain associated with rectal tenesmus that did not improved despite symptomatic treatment. Routine biological
The Importance of Design Elements in Special Education of Individuals with Autism and Learning Disabilities

This study examines the fundamental relationship between design and special education. The paper presents a literature review on autism learning difficulties and special education, including the scope of sensors, training, accessibilities, learning methods and requirements, and their connection with design needs. According to the study, the benefits of using specially designed elements in special education can contribute to the student’s learning and perception processes. A further recommendation is to develop more research in educational materials specially designed according to an individual’s design needs in reading, acquiring essential life skills, and communication. Keywords: Autism, design, special education
Semi-infinite crack between two dissimilar orthotropic strips

Abstract The problem of a semi-infinite crack between two dissimilar orthotropic strips has been solved. Using the Fourier transform technique the problem has been converted to a standard Wiener-Hopf equation which has been solved for asymptotic cases only to deduce the expressions for the stress intensity factor and crack opening displacement. Finally the values of the stress intensity factor and crack opening displacement have been plotted graphically to show the effects of strip width and material orthotropy.
Prevalence of BRAF V600E Mutation in the Iranian Patients with Hairy Cell Leukemia: A Retrospective Study

Hairy cell leukemia (HCL) is a rare and slow-growing hematological malignancy with unknown etiology, accounting for 2% of all leukemias. It is a very heterogeneous group of B‐cell disorders characterized by excessive B-cell proliferation in the bone marrow with a hairy look under the microscope. The patients are generally presented with pancytopenia and splenomegaly, as well as non-specific clinical symptoms such as fatigue and weakness [1]. Although the etiology of HCL is not well identified, a connection between specific gene mutations has been elucidated [2]. MAP kinase cascade is a key signaling pathway that mediates a wide variety of cellular functions, including cellular growth, proliferation, differentiation, and apoptosis. Activation of the MAP kinase pathway is a frequent event in tumorigenesis. The BRAF gene is Abstract
Effect on sediment delivery ratio by changes in land use land cover and construction of hydraulic structures at sub basin scale

Many areas of the world are particularly vulnerable to sedimentation. Determining the amount of soil erosion and sediment rate from watersheds would be the first step in reducing sedimentation. Soil and Water Analysis Tool (SWAT) based on Geographic Information System (GIS) was used to determine sediment yield and Sediment Delivery Ratio (SDR). This paper’s main objective is to assess the impact of land-use change on SDR at the sub-basin scale. Land-use changes indicated a vast reduction of 19% in the forest area, which causes an increase in agricultural land and commercial land. Therefore, SDR must be increased, but the study area’s average SDR trend is decreasing from 1985 to 2015. But, sub-basin-scale, sub-basins no. 17, 18, and 24 are decreasing from 1985 to 2005 and increasing from 2005 to 2015.
Symmetry constraints on the Hartree-Fock model: II. Basis set superposition errors and the ‘Algebraic Approximation’

It is shown that the removal of the ‘spherical approximation’ from the Atomic Hartree-Fock equations generates a set of atomic orbitals which are not always eigenfunctions of L 2. In particular, the s-type and d-type orbitals ‘mix’. The result of this mixing is to generate a set of ‘valence’ orbitals for these atoms which solves the old problem of why, if the 3d lies below the 4s, does the 3d not always fill up first.
An Efficient Methodology for the Evaluations of Select Operation in Query Optimization

brought the mutiny in the Information technology by making users free from the burden of developing logic for solution of the application problem. At the same time, it enhanced the need for implementation of ameliorated strategies to evaluate the intermediate operations. The development of 4GLs freed the users from the strained design of ‘how to do it’ for solutions of their applications. At the back end, it increased the complexity of transformation from non-procedural query to procedural query. The query processing and optimization manages these transformations, by transforming 4GLs query into appropriate relational algebra/calculus expression in the first phase, minimizing the operations in the next phase and then evaluating the expression through the efficient strategies for such operations in the third phase. The transformation to relational algebra/calculus expression and minimizing operations are straightforward processes. The development of ameliorated strategies depends on the file organizations used in the storing relations of the database (Secondary storage structures). This paper discusses the strategies designed for select operation, when tuples of operand relations are stored in one of various file organizations in the database. Here, an attempt is made to design ameliorated algorithms to evaluate select operation when the tuples of the operand relations are stored in any of the file organizations like (i) sequential file (ii) indexed sequential files with B-tree file having number of key field indexes in each node and B+ tree file organizations for multiple indexes where data pointers are stored in each leaf node of the multilevel indexes of the file organization. The literature available suggests that, there are good methods available when key fields are primary keys. The authors have not noticed any clear cut strategies, when key fields for indexing are non primary keys (non candidate keys). Here, an attempt is made to develop the strategies, when key fields are non-candidate keys.
Beach volleyball spike arm swing techniques of Olympics and world championships winners (1996–2019) reveal gender differences

The spike attack is one of the most important skills in beach volleyball, and as an overarm movement, places significant load on the shoulder joint that could lead to increased risk of injury. An analysis of the different techniques used by elite athletes could provide important insights regarding the etiology of these injuries. This study aimed to assess the spike attack arm swing techniques of Olympics and World Championships (1996-2019) beach volleyball winners and to investigate possible gender differences. Twenty-five male and twenty female winners were assessed on video recordings from eighteen competitions. The different arm swing techniques in the cocking phase (Straight, Bow-and-arrow high, Bow-and-arrow low, Snap, and Circular) were classified by two experts. Intra-rater reliability of both experts (κ = 1.000, P < .001 and κ = .969, P < .001 respectively) and inter-rater reliability (κ = .969, P < .001), assessed by Cohen’s Kappa, were almost perfect. There were significant gender differences in arm swing techniques (P < .001) with a large size effect (Cramer’s V = .650). The most frequent technique for men was the Bow-and-arrow low (56%) followed by Circular (24%) and Bow-and-arrow high (20%), while for women were the Bow-and-arrow high (30%) and Snap (30%), followed by Bow-and-arrow low (25%) and Straight (15%). The results showed a great variation in arm swing techniques even among world class beach volleyball players as well as significant gender differences, and could allow us to develop interesting hypotheses regarding the mechanisms that could lead to shoulder overuse injuries.
Formation and Evolution of Magnetised and Turbulent Molecular Clouds : Varying Initial Conditions and the Role of Stellar Feedback

Mittels hochaufgeloster numerischer Simulationen untersuche ich die Entstehung und Entwicklung von Molekulwolken, welche durch die Kollision zweier Gasstrome im interstellaren Medium hervorgerufen wird. In einer ersten Studie untersuche ich den Einfluss des interstellaren Magnetfeldes auf den resultierenden Entstehungsprozess, sowie den weiteren zeitlichen Verlauf. Ich zeige, dass starke Magnetfelder – wie sie derzeit beobachtet werden – zu einer Unterdruckung des Gravitationskollaps und damit der Sternentstehung fuhren. Auf Basis von nicht–idealer Magnetohydrodynamik fuhre ich weitere Studien durch. Die Ergebnisse zeigen jedoch keine signifikante Anderung, was letztendlich zu der Frage fuhrt, wie Sterne in kalten, stark magnetisierten Wolken entstehen. Weiterhin gehe ich die Frage an, welchen Effekt Supernova–Explosionen massereicher Sterne auf die elterliche Molekulwolke haben. Ich zeige, dass das Lebensende eines massereichen Sterns nur einen sehr lokal begrenzten Effekt aufweist. Die globale Stabilitat der Wolke wird dabei nur kurzweilig durch die Supernova dominiert. Auf Skalen von ca 10 − 20 pc jedoch erweisen sich Supernova–Explosionen als auserst effizient im Vergleich zu anderen Ruckkopplungsmechanismen. Hinsichtlich der Sternentstehungsrate und –effizienz kann eine Verringerung um einen Faktor 2 vermerkt werden. Ein vollstandiges Ende der Sternentstehung wird jedoch nicht beobachtet. I present results from high resolution numerical simulations studying the formation and subsequent evolution of molecular clouds driven by the convergence of warm neutral medium flows. The results highlight the importance of magnetic fields in the diffuse interstellar medium as well as the initial conditions of the formation process. I show that magnetic field strengths consistent with recent observational results do not lead to gravitationally collapsing clumps within the clouds. Non–ideal magnetohydrodynamic effects, which increase the diffusion of the magnetic field show only minor difference compared to ideal magnetohydrodynamics. I conclude that the issue of how stars form in highly magnetised environments still persists. In a second step, I study the evolution of star forming molecular clouds subject to supernova feedback from high–mass stars. I show that this feedback process is too inefficient to disrupt the parental molecular cloud. The long–term energy and momentum input are not sufficient to disperse the gas. On spatial scales of about 10−20 pc, however, supernova feedback is seen to be much more efficient than corresponding other feedback mechanisms prior to the supernova. The impact on the star formation rate and efficiency is rather limited. Both quantities are reduced by a minimum factor of about 2, but do not come to a halt.