Miracle-dz/UniFAR-FTUs huggingface dataset:
Acoustic Wave Equations for a Linear Viscous Fluid and An Ideal Fluid

The mathematical description of acoustic wave propagation within a time- and space-varying, and moving, linear viscous fluid is formulated as a system of coupled linear equations. This system is rigorously developed from fundamental principles of continuum mechanics (conservation of mass, balance of linear and angular momentum, balance of entropy) and various constitutive relations (for stress, entropy production, and entropy conduction) by linearizing all expressions with respect to the small-amplitude acoustic wavefield variables. A significant simplification arises if the fluid medium is neither viscous nor heat conducting (i.e., an ideal fluid). In this case the mathematical system can be reduced to a set of five, coupled, first-order partial differential equations. Coefficients in the systems depend on various mechanical and thermodynamic properties of the ambient medium that supports acoustic wave propagation. These material properties cannot all be arbitrarily specified, but must satisfy another system of nonlinear expressions characterizing the dynamic behavior of the background medium. Dramatic simplifications in both systems occur if the ambient medium is simultaneously adiabatic and stationary.
Screening for Partner Postpartum Depression

Abstract Background: Postpartum depression is a significant mental health condition affecting an estimated 7% to 20% of women, with higher rates among individuals with increased risk factors. Most research on postpartum depression has focused on mothers, with less recognition of the mental health changes experienced by their partners. Research suggests almost 20% of partners may experience postpartum depression, yet our understanding is limited. An enhanced understanding of postpartum depression in a birthing person's partner is critical, given the mental and physical health sequelae associated with depression. Purpose: The purpose of this review was to systematically examine the current tools available to assess partner postpartum depression. Methods: We conducted a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligible studies were identified using selected key terms in PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, and Ovid MEDLINE. Studies were included if they assessed partner depressive symptoms and identified the specified use of a tool or screening measure. Results: Seventeen studies met inclusion criteria. Seven different measures were used to assess postpartum depression. The Edinburgh Postnatal Depression Scale (EPDS) was used in 16 out of the 17 studies for depression assessment. Clinical Implications: Routine screening of partners for postpartum depression should be recommended as part of standard care. Nurses are critical liaisons for assessing risk and connecting relevant and timely resources to birthing people and their partners. Identifying the available screening tools may help to avoid adverse clinical outcomes associated with increased symptom severity and burden. Most of the research on postpartum depression has focused on new mothers, however their partners can experience depression during postpartum as well. In this systematic review, articles that described screening tools for partner postpartum depression are evaluated. Recommendations for nursing practice are presented.
SGLT2 inhibition to address the unmet needs in diabetic nephropathy

Current treatment of diabetic nephropathy is effective; however, substantial gaps in care still remain and new therapies are urgently needed to reduce the global burden of the complication. Desirable properties of an “ideal” new drug should include primary prevention of microalbuminuria, additive/synergistic anti‐proteinuric effect in combination therapy with renin angiotensin system blockers, reduction of chronic kidney disease progression to lower the risk of end‐stage renal disease, and cardiovascular protection. Growing evidence suggests that sodium‐glucose cotransporter 2 inhibitors (SGLT2i) may fulfil many of these criteria and represent novel tools to cover the unmet needs in diabetic nephropathy care. However, the underlying mechanisms of SGLT2i renal benefits are still poorly understood and promising results from cardiovascular outcome trials with SGLT2i need confirmation in dedicated renal outcome trials.
Longitudinal Trajectories of Post-Concussive Symptoms Following Mild Traumatic Brain Injury

ABSTRACT Background Individuals recovering from mild traumatic brain injury (TBI) represent a heterogenous population that requires distinct treatment approaches. Identification of recovery trajectories improves our ability to understand the natural history of mild TBI recovery and develop targeted interventions. Objective To utilize group-based trajectory modeling (GBTM) to identify distinct patterns of symptom recovery following mild TBI in the first 6 months after mild TBI. Methods This study is comprised of 253 adults who presented to the emergency department with mild TBI and completed assessments for six-months post-injury. Patients were recruited for the prospective observational cohort study, HeadSMART. The primary outcome measure was the Rivermead Postconcussion Symptom Questionnaire. GBTM was used to identify longitudinal trajectories of recovery following mild TBI using Rivermead scores at baseline, one, three, and six months following diagnosis. Results Findings identified four distinct trajectories of symptom recovery follwing mild TBI including 9% of participants who were categorized with minimal acute symptoms that decreased over time, 45% with mild acute symptoms that decreased over time, 33% with relatively higher acute symptoms that decreased over time, and 13% with relatively higher acute symptoms that increased over time. Conclusions GBTM identified four distinct trajectories of recovery following mild TBI and GBTM may be useful for research interventions that can alter recovery trajectories.
Prediction of Longitudinal Cognitive Decline in Preclinical Alzheimer Disease Using Plasma Biomarkers

Key Points Question Can plasma biomarkers predict cognitive decline in preclinical Alzheimer disease (AD)? Findings In this prognostic study of data from 2 preclinical AD cohort studies including 171 cognitively unimpaired individuals with cerebrospinal fluid or positron emission tomographic measures of β-amyloid positivity, plasma P-tau217 significantly predicted longitudinal cognitive decline in both cohorts. Meaning These findings suggest that plasma P-tau217 may be used as a complement to cerebrospinal fluid and positron emission tomography for participant selection in clinical trials of novel disease-modifying treatments.
Convergent and divergent roles of the glucose-responsive kinase SNF4 in Candida tropicalis

ABSTRACT The sucrose non-fermenting 1 (SNF1) complex is a heterotrimeric protein kinase complex that is an ortholog of the mammalian AMPK complex and is evolutionally conserved in most eukaryotes. This complex contains a catalytic subunit (Snf1), a regulatory subunit (Snf4) and a scaffolding subunit (Sip1/Sip2/Gal73) in budding yeast. Although the function of AMPK has been well studied in Saccharomyces cerevisiae and Candida albicans, the role of AMPK in Candida tropicalis has never been investigated. In this study, we focused on SNF4 in C. tropicalis as this fungus cannot produce a snf1Δ mutant. We demonstrated that C. tropicalis SNF4 shares similar roles in glucose derepression and is necessary for cell wall integrity and virulence. The expression of both SNF1 and SNF4 was significantly induced when glucose was limited. Furthermore, snf4Δ strains exhibited high sensitivity to many surface-perturbing agents because the strains contained lower levels of glucan, chitin and mannan. Interestingly, in contrast to C. albicans sak1Δ and snf4Δ, C. tropicalis snf4Δ exhibited phenotypes for cell aggregation and pseudohypha production. These data indicate that SNF4 performs convergent and divergent roles in C. tropicalis and possibly other unknown roles in the C. tropicalis SNF1-SNF4 AMPK pathway.
Frontline Science: TLR3 activation inhibits food allergy in mice by inducing IFN‐γ+ Foxp3+ regulatory T cells

The pathologic feature of food allergy (FA) is the aberrant Th2‐biased immune response in the intestine. Regulatory T cells (Tregs) play an important role in the suppression of aberrant immune response. The activities of the TLRs regulate multiple cell functions. This study aims to investigate the role of TLR3 activation in the regulation of Th2‐biased immune response in the intestine by the generation of inducible Tregs (iTregs). In this study, polyinosinic polycytidylic acid (polyI:C) was used as an activator of TLR3. An FA mouse model was developed to establish the Th2‐biased inflammation in the intestine. The effects of TLR3 activation on the generation of iTreg were tested in the culture and in mice. We observed that exposure to polyI:C induced IFN‐γ+ Foxp3+ iTregs in mouse intestine and in the culture. The IFN‐γ+ Foxp3+ iTregs showed immune suppressive functions. Exposure to polyI:C increased T‐bet levels in CD4+ T cells. The T‐bet formed a complex with GATA3 to dissociate Foxp3 from GATA3/Foxp3 complex in CD4+ T cells. The Foxp3 thus gained the opportunity to move to TGF‐β promoter to generate iTregs. Administration with polyI:C prevented the development of FA and inhibited existing FA. In conclusion, activation of TLR3 induces IFN‐γ+ Foxp3+ Tregs, which can prevent FA development and inhibit existing FA in mice.
Remote assessment of quality, processing and economic criteria in qualification of suppliers to the meat packaging foil producer—A Greek case study

Supervision over the suppliers of packaging as well as suppliers of raw materials for packaging production is important to ensure the quality and safety of meat products. The aim of this study was to verify the remote evaluation procedure of quality, processing and economic criteria in qualification of raw materials suppliers to the meat packaging foil producer during the Covid-19 pandemic. The evaluation was done remotely in terms of meeting some of the requirements of the quality management system (QMS) in conditions where regular audit could not be carried out. The survey was conducted in one of the biggest packaging foil producers in Greece via its supplier evaluation. The evaluation consisted of: 1/ economic criteria and 2/ quality and processing criteria. The highest and the lowest rated economic criteria were procedural compliance and price of raw materials. Among the quality and processing criteria, the highest score was given to warranties and claims policies and material quality, and the lowest one to lead time. The highest ratings obtained suppliers of raw materials directly involved in production, suppliers from Greece, the USA and Denmark, as well as suppliers to the R&D department. The results of the study showed that the quality of the raw materials directly used in the production of packaging foil was adequate. Therefore, their use ensure production of packaging foil and finally packaged meat products of adequate quality and safety. The presented procedure occurred to be useful for remote evaluation of quality, processing and economic criteria in qualification of suppliers during the Covid-19 pandemic. It may inspire other producers of food packaging materials to continuing supervision over their suppliers while regular methods of control are limited.
Accumulation and distribution of heavy metals in soil and food crops in the Pb–Zn mine environ. Case study: Region of Probištip, North Macedonia

Abstract The aim of the study was to investigate the exploration and distribution of various chemical elements in soils and vegetables from gardens in the region of Probištip, North Macedonia. This region was exposed to heavy metals pollution from Pb–Zn mining and flotation tailings landfill near the town of Probištip for 70 years. A total of 38 samples of various crops and vegetable products from 19 gardens were analyzed. The analyzes were carried out by ICP-AES (Al, Ba, Ca, Cr, Cu, Fe, K, Li, Mg, Mn, Na, Ni, P, Pb, Sr, V, and Zn) and by ICP-MS (As, Cd, Co, Cr, and Pb). It was found that the content of some potentially toxic elements (As, Cd, Cu, Pb, and Zn) in the soil samples from the gardens, exceeded the target values. From these results, it is clear that the contamination of the soils in this area is due to mining activities and the distribution of flotation wastes from the nearby flotation dump. It was also found that the contaminated soils lead to elevated levels of these elements in some vegetables from the gardens, especially those near the Zletovska River and the flotation waste landfill, exceeding the nationally permissible food content.
Beyond mortality: definitions and benchmarks of outcome standards in paediatric anaesthesiology

Purpose of review The aim of this study was to review the evolution of safety and outcomes in paediatric anaesthesia, identify gaps in quality and how these gaps may influence outcomes, and to propose a plan to address these challenges through the creation of universal outcome standards and a paediatric anaesthesia designation programme. Recent findings Tremendous advancements in the quality and safety of paediatric anaesthesia care have occurred since the 1950 s, resulting in a near absence of documented mortality in children undergoing general anaesthesia. However, the majority of data we have on paediatric anaesthesia outcomes come from specialized academic institutions, whereas most children are being anaesthetized outside of free-standing children's hospitals. Summary Although the literature supports dramatic improvements in patient safety during anaesthesia, there are still gaps, particularly in where a child receives anaesthesia care and in quality outcomes beyond mortality. Our goal is to increase equity in care, create standardized outcome measures in paediatric anaesthesia and build a verification system to ensure that these targets are accomplished. The time has come to benchmark paediatric anaesthesia care and increase quality received by all children with universal measures that go beyond simply mortality.
The therapeutic threshold in clinical decision-making for TB

Abstract Because TB control is still hampered by the limitations of diagnostic tools, diagnostic uncertainty is common. The decision to offer treatment is based on clinical decision-making. The therapeutic threshold, test threshold and test-treatment threshold can guide in making these decisions. This review summarizes the literature on methods to estimate the therapeutic threshold that have been applied for TB. Only five studies estimated the threshold for the diagnosis of TB. The therapeutic threshold can be estimated by prescriptive methods, based on calculations, and by descriptive methods, deriving the threshold from observing clinical practice. Test and test-treatment thresholds can be calculated using the therapeutic threshold and the characteristics of an available diagnostic test. Estimates of the therapeutic threshold for pulmonary TB from intuitive descriptive approaches (20%–50%) are higher than theoretical prescriptive calculations (2%–3%). In conclusion, estimates of the therapeutic threshold for pulmonary TB depend on the method used. Other methods exist within the field of decision-making that have yet to be implemented or adapted as tools to estimate the TB therapeutic threshold. Because clinical decision-making is a core element of TB management, it is necessary to find a new, clinician-friendly way to unbiasedly estimate context-specific, agreed upon therapeutic thresholds.
Femtosecond diode-pumped Cr:LiSGAF lasers

The design and performance of diode-pumped Cr:LiSrGaAlF/sub 6/ lasers mode-locked by Kerr-lens mode-locking and a solid-state saturable absorber are described. The different regimes of operation of the laser mode-locked by the saturable absorber are discussed. Both lasers generate 100-fs pulses with average powers of 40 mW and low fluctuations.
Immunogenic antitumor potential of Prakasine nanoparticles in zebrafish by gene expression stimulation

Abstract In this study, non-toxic mercury nanoparticle was synthesized as per “Prakash theory of metal drugs” and nanoparticle’s characters has been demonstrated by employing several nanotechnological tools including XPS, XRD, EDAX. The size of the Prakasine nanoparticles (PRK-NP) ranged from 90–100 nm, confirmed using TEM, SEM, DLS and along with zeta potential of −29.5 mV before storage and −8.5 mV after storage. The FTIR provided information regarding the nanoparticle capping and functional groups. The study was further elaborated for determining PRK-NPs toxicity, genotoxicity, in-vivo toxicity, immunological anti-tumour activity, immunogenicity potential, gene expression profiling and confirmed by MTT and apoptosis assays, cancer zebrafish model studies and WBC proliferation assay. PRK-NPs revealed no cytotoxicity where cell viability was observed 99% in L6 mouse fibroblasts and 99% in MCF-7 cell lines. Also, the cell viability was to be 89.47% at a very high concentration of 320 µg/ml in HEK 293 cells. The PRK-NPs significantly reduced the tumour in zebrafish at dose of 90 μg/g by up regulating IL-1α, IL-1β, IL-2-ITK, IL-6, IL-8, IL-12, TNF-α and IFN-γ, and down regulating IL-4, IL-5, IL-10 and TGF-β compared to untreated controls without any adverse effects and toxicity. Thus, the current study beholds anticipation PRK-NPs may play a vital role in therapeutic.
Association of diet quality during pregnancy with maternal glucose metabolism in Chinese women

Abstract Overall diet quality during pregnancy has played an important role on maternal glucose metabolism. However, evidence based on the adherence to the dietary guideline is limited, especially for Asian populations. We aimed to examine the association between adherence to the Chinese dietary guideline measured by the Diet Balance Index for Pregnancy (DBI-P) and maternal glucose metabolism, including gestational diabetes mellitus (GDM) status, fasting and 2-h plasma glucose. Data were obtained from the baseline survey of the Yuexiu birth cohort. We recruited 942 pregnant women at 20–28 weeks of gestation in 2017–2018. Dietary intakes during the past month were collected using a validated semi-quantitative FFQ. The scores of DBI-P were calculated to assess dietary quality. Lower absolute values of the scores indicate higher adherence to the Chinese dietary guidelines. All participants underwent a 75 g of oral glucose tolerance test (OGTT). Multiple linear regression and logistic regression were conducted. The Benjamini–Hochberg method was used to adjust multiple comparisons across DBI-P food components. The value of high bound score indicator, reflecting excessive total food intake, was positively associated with OGTT-2h glucose levels (β = 0·037, P = 0·029). After adjustment for multiple comparisons, the score of animal food intake was positively associated with OGTT-2 h glucose levels (β = 0·045, P = 0·045) and risk of GDM (OR = 1·105, P = 0·030). In conclusion, excessive total food intake was associated with higher postprandial glucose in pregnant women. Lower compliance with the dietary guideline for animal food was associated with both higher postprandial glucose and increased risk of GDM during pregnancy.
Influence of particle plasmon resonance on the photoluminescence of organic semiconductor blend

We investigate the influence of particle plasmon resonance of Au nanoislands structures on the exciplex emission in the polymer blend of poly (9, 9'-dioctylfluorene-co-benzothiadiazole) (F8BT) and poly (9,9'-dioctylfluorene-co-bis-N,N'- (4-butylphenyl)-bis-N,N'-phenyl-l,4-phenylenediamine) (PFB). The experimental results indicate that when the particle plasmon resonance of the gold nanoisland structures overlaps the spectral range of the exciplex emission, significant enhancement of the photoluminescence can be observed. Furthermore, longer lifetime has been measured for the red-shift emission of the exciplex. We proposed that the localized field due to the particle plasmon resonance of the Au nanoislands has modulated the mechanisms for the formation of exciplex, which may be related to the exciton diffusion, charge transfer, and phase separation at the interface between the two materials.
Additive fungal interactions drive biocontrol of Fusarium wilt disease.

Host-associated fungi can help protect plants from pathogens, and empirical evidence suggest that such microorganisms can be manipulated by introducing probiotic to increase disease suppression. However, we still generally lack the mechanistic knowledge of what determines the success of probiotic application, hampering the development of reliable disease suppression strategies. We conducted a 3-season consecutive microcosm experiment in which we amended banana Fusarium wilt disease-conducive soil with Trichoderma-amended biofertilizer or lacking this inoculum. High-throughput sequencing was complemented with cultivation-based methods to follow changes in fungal microbiome and explore potential links with plant health. Trichoderma application increased banana biomass by decreasing disease incidence by up to 72%, and this effect was attributed to changes in fungal microbiome, including the reduction in Fusarium oxysporum density and enrichment of pathogen-suppressing fungi (Humicola). These changes were accompanied by an expansion in microbial carbon resource utilization potential, features that contribute to disease suppression. We further demonstrated the disease suppression actions of Trichoderma-Humicola consortia, and results suggest niche overlap with pathogen and induction of plants systemic resistance may be mechanisms driving the observed biocontrol effects. Together, we demonstrate that fungal inoculants can modify the composition and functioning of the resident soil fungal microbiome to suppress soil-borne disease.
On Hilberg's law and its links with Guiraud's law*

Abstract Hilberg (1990) supposed that finite-order excess entropy of a random human text is proportional to the square root of the text length. Assuming that Hilberg's hypothesis is true, we derive Guiraud's law, which states that the number of word types in a text is greater than proportional to the square root of the text length. Our derivation is based on some mathematical conjecture in coding theory and on several experiments suggesting that words can be defined approximately as the nonterminals of the shortest context-free grammar for the text. Such operational definition of words can be applied even to texts deprived of spaces, which do not allow for Mandelbrot's “intermittent silence” explanation of Zipf's and Guiraud's laws. In contrast to Mandelbrot's, our model assumes some probabilistic long-memory effects in human narration and might be capable of explaining Menzerath's law.