Miracle-dz/UniFAR-FTUs huggingface dataset:
The influence of non-steroidal anti-inflammatory drugs with different mechanisms of action on the course of stress reaction, the functional state of kidneys, liver, and heart on the model of acute general cooling

Inhibitors of the arachidonic acid cascade have significant potential as the agents for the prevention of severe cold injuries. The results of the previous studies have demonstrated the pronounced frigoprotective properties of certain non-steroidal anti-inflammatory drugs, primarily diclofenac sodium, etoricoxib, darbufelone mesylate, under the conditions of acute general cooling. The aim of the study: to investigate the effect of non-steroidal anti-inflammatory drugs with various mechanisms of action on the course of the stress reaction, the functional state of the kidneys, liver, and heart using the model of acute general cooling. Materials and Methods: The experiment was carried out using 35 outbreed male rats weighing 256±5 g. The studied drugs were administered intragastrically 30 minutes before cold injury modelling: diclofenac sodium at a dose of 7 mg/kg, etoricoxib at a dose of 5 mg/kg, darbufelone mesylate at a dose of 20 mg/kg. Acute general cooling was induced by exposure at –18 °C for 2 hours. The efficacy of the studied drugs was evaluated by the values as follows: the body temperature (measured rectally), the course of a stress reaction according to the criteria of “the stress triad”, the functional state of the kidney and liver according to the changes in the blood serum biochemical parameters, the functional state of the heart according to the electrocardiogram. Results: It was found that etoricoxib and darbufelone mesylate, and especially diclofenac sodium, demonstrate frigoprotective properties, reducing the severity of hypothermia, have stress-protective activity and a beneficial effect on the functional state of the kidneys. All investigated non-steroidal anti-inflammatory drugs prevent a decrease in myocardial contractility (by the effect on the systolic index) and lengthening of the QT interval caused by acute cold injury. Diclofenac sodium, unlike etoricoxib and darbufelone mesylate, does not enhance the effect of acute general cooling on intraventricular conduction. Under acute exposure to cold, no significant changes in the functional state of the liver were observed, including the groups receiving the nonsteroidal anti-inflammatory medicines. Conclusions: The prophylactic administration of the arachidonic acid cascade inhibitors, especially the non-selective COX-2 inhibitor diclofenac sodium, reduces the severity of the stress response, contributes to the maintenance of the renal and cardiac function. There are no significant changes in the functional state of the liver under conditions of the experiment
Effect of Al Additions and Cooling Rate on the Microstructure and Mechanical Properties of Austenite FeMnAlC Steels

The precipitation behavior of κ-carbide and its effects on mechanical properties in Fe-30Mn-xAl-1C (x = 7–11%) steels under water quenching and furnace cooling are studied in the present paper. TEM, XRD, EPMA were employed to characterize the microstructure, and tensile test and the Charpy impact test were used to evaluate mechanical properties. The results show that the density decreases by 0.1 g/cm3 for every 1 wt. % of Al addition. The excellent mechanical properties of tensile strength of 880 MPa and impact absorption energy of 120–220 J at −40 °C with V notch were obtained, with both solid solution and precipitation strengthening results in the yield strength increasing by about 57.5 MPa with per 1% Al addition in water-quenched samples. The increasing of yield strength of furnace-cooled samples comes from the relative strengthening of κ-carbides, and the strengthening potential reaches 107–467 MPa. The lower the cooling rate, the easier it is to promote the precipitation of κ-carbides and the formation of ferrite. The partitioning of C, Mn, Al determines the formation of κ-carbides at a given Al addition, and element partition makes the κ-carbides sufficiently easy to precipitate at a low cooling rate. The precipitation of κ-carbides improves strength and does not significantly reduce the elongation, but significantly reduces the impact absorption energy when Al addition ≥ 8%.
Calculating $\Delta m_K$ with lattice QCD

We have completed a lattice QCD calculation of $\Delta m_K$, the mass difference between the long- and short-lived K mesons. The calculation was performed on a $64^3 \times 128$ lattice using 152 configurations with physical quark masses and an inverse lattice spacing of $1/a=2.36$ GeV. While the statistical error approaches a relatively small size of 9%, several sources of systematic errors may have more significant effects. In this paper we will address studies performed on smaller lattices to estimate the systematic errors in our result.
IoT Enabled Intra-Vehicular Communication for Designing A Smart Car

Nowadays, the number of sensor nodes in the vehicle has expanded altogether because of the expanding of various vehicular applications. Moreover, the wired connection is not adaptable and flexible due to the internal structure of the vehicle, thus, there is an expanding level of appeal to design a system in which the wired connections with the sensor node are supplanted with wireless connections. Design a wireless sensor system inside the vehicle is quite challenging than other systems, e.g., wireless, sensor and computer network, due to the unpredictable environment inside the vehicle. In this project, we discuss about Internet of Things (IoT) enabled Intra-Vehicular Communication for Designing a Smart Car. IoT enabled Intra-Vehicular Communication (IoT-IVC) refers to the system where huge number of sensors are associated with each other for sharing the car components’ information to build up a smart vehicular system. The marvel of congestion represents an issue in the IoT-IVC while the traffic load and number of sensors are expanded. A new scheduling algorithm is proposed for minimizing the congestion. A Test-Bed is designed in order to validate the proposed algorithm. The experimental results justify the effectiveness of the proposal.
Medical concept integrated residual short‐long temporal convolutional networks for predicting clinical events

Large collections of electronic clinical data today provide us with a vast source of information on medical practice. However, the utilization of those data for exploratory analysis to support clinical decisions is still limited. It is particularly challenging for extracting useful disease progression patterns from such data because it is longitudinal, incomplete, irregular, and heterogeneous of the patient conditions. In this article, we propose an integrated clinical event prediction model medical concept integrated residual short‐long temporal convolutional networks (SL‐TCN) to address these challenges. Compared to existing models, our model has three‐fold advantages: (1) it learns a compact set of medical concepts as the bridge between the hidden progression process and the observed medical evidence. (2) it learns a continuous‐time progression model from discrete‐time observations with nonequal intervals and high‐dimensional features. (3) We fuse the temporal convolutional network, the long short‐term memory network, and the residual connector so as to capture the local and global dependency of the sequence and make the clinical event predictions more robust. Through extensive experiments on the MIMIC III dataset, we demonstrate that our SL‐TCN achieves higher precision in clinical event prediction and derives some interesting clinical insights.
Data-Driven Signal Detection for Underwater Acoustic Filter Bank Multicarrier Communications

By contraposing the signal detection for filter bank multicarrier (FBMC) communications with the underwater acoustic (UWA) channel, this paper analyzes the traditional imaginary interference problem and proposes a deep learning-based method. The neural network with feature extraction and automatic learning ability is employed to replace the demodulation modules to recover transmitted signals without explicit channel estimation and equalization. Sufficient data sets are generated according to the measured channel conditions in Qingjiang river, the optimization of network parameters is finished by constraining cost function in offline training, and the signal detection is carried out directly with the well-trained network in online testing. The system performance of various supervised learning models such as multilayer perceptron (MLP), convolutional neural network (CNN), and bidirectional long short-term memory (BLSTM) network is compared under different data sizes, network parameters, and prototype filters. The simulation results show that the bit error rate (BER) performance of the proposed signal detection is better than that of the classic one, which indicates that deep learning is a promising tool in UWA communication systems.
A Wideband Multi-Level Reconfigurable Class E/F23 Power Amplifier with A Band-Selecting Tracking Reactance Compensation Automatic Calibration Algorithm

This paper presents a wide-band multi-level switched mode class-E/F23 Power Amplifier (PA) with a reconfigurable power stage core transistor and a load with reconfigurable reactance compensation part. An Automatic Calibration Scheme (ACS) is proposed to perform the core and load reconfiguration based on a proposed algorithm. The PA is formed by a class-D driver amplifier, the switched mode cascaded reconfigurable power stage, the reconfigurable class-E/F23 load, the ACS and its algorithm, and the matching network at the end of the load before the antenna. The proposed PA is implemented using a 130 nm CMOS technology. The wideband PA operates in the frequency range from 470 MHz to 690 MHz for a TV White Space (TVWS) application with 220 MHz bandwidth. Even though reaching a high maximum Power Added Efficiency (PAEmax) for the design with low output powers is challenging a PAEmax of 32% for a 10 dBm output power level from a low supply voltage of 2.2 V. The proposed ACS provides an output power with a flatness around 0.6 dB which shows 57% improvement in compare with the structure without the ACS. The PA achieved a selectable multi-level output power from 10 dBm to 14 dBm over the 220 MHz bandwidth.
Sleep, Sensory Integration/Processing, and Autism: A Scoping Review

The prevalence of sleep dysfunction is considerably higher in the autistic population than in the non-autistic. Similarly, the incidence of sensory reactivity differences in autism exceeds that in the neurotypical population. The basis of sleep disorders in autism is multifactorial, but sensory integration/processing concerns may play a role. Research that investigates this interplay for autistic individuals is limited but vital. In this scoping review, we examined literature addressing the following research question: What is the relationship between sleep and sensory integration/processing in autism? We included articles if they were peer-reviewed, English or Spanish, purposefully addressed sensory integration/processing differences, were sleep focused and included autism as the primary diagnosis or population. Articles were excluded if the language was not English or Spanish, research was conducted with animals, they were non-peer-reviewed, the primary population was not autistic, the sensory focus reflected a specific sensorineural loss (e.g., blindness, or deafness), there was not a clear inclusion of sensory integration/processing or sleep. We searched six databases and included all citations from the inception of each database through June 2021. The search strategy identified 397 documents that were reduced to 24 included articles after exclusion criteria were applied. The majority of studies we identified characterized the relation between sleep and sensory integration/processing differences in autism. Investigators found multiple sleep concerns such as bedtime resistance, sleep anxiety, delayed sleep onset, night awaking, and short sleep duration in autistic individuals. Identified sensory concerns focused on reactivity, finding hyper- and hypo-reactivity as well as sensory seeking across sensory domains. Co-existence of sleep concerns and sensory integration/processing differences was frequently reported. Few intervention studies showed a clear sensory focus; those that did emphasized pressure, movement, touch, and individual sensory preferences/needs. Swimming programs and massage showed promising results. No studies were of high quality. At a minimum, there is a co-existence of sensory reactivity differences and sleep concerns in autistic children, and possibly autistic adults. The relationship between poor sleep and sensory integration/processing differences is complex and multi-faceted, requiring additional research. Interventions that purposefully include a central sensory component have not been well studied in autistic children or adults. Overall studies with greater rigor and purposeful use of sensation and sensorimotor supports as a component of intervention are needed. This study was not funded.
Cu-doped TiO2-x nanoscale memristive applications in chaotic circuit and true random number generator

TiO2 has attracted significant attention as a prototypical material for memristors. In this paper, a Cu-doped TiO2-x nanoscale memristor with structure of Ti/TiO2-x:Cu/Cu is built, whose faithful mathematical model is established based on the memristive behaviors and its switching mechanism. Using this model, a chaotic system is constructed and its complex dynamics are investigated by numerical simulations. Furthermore, hardware experiments are also designed to verify the model in chaotic circuit. The chaotic attractors obtained by simulations and hardware experiments are consistent, demonstrating the reliable performance of the Ti/TiO2-x:Cu/Cu memristor and the correctness of its mathematical model. The processes of memristor from manufacture and mathematical modeling to its verification in a chaotic circuit are presented.
Effect of strategic mineral supplementation on the occurrence of hemoglobinuria in pregnant buffaloes

The supplementation study was carried out in 20 advanced pregnant buffaloes selected from the area of study. Availability of major elements (Ca, P and Mg), trace elements (Fe, Cu, Mn, Zn,) for animals were calculated on the basis of mineral composition of feedstuffs and feed intake. The mineral availability of individual animal was compared with the nutrient requirements calculated with the help of feeding standards. Results indicated that there was shortage of phosphorus 40.34%, zinc 86.34% and copper 46.26%. But calcium, magnesium, iron, and manganese was shown to be supplied in excess 394.87%, 177.22%, 309.09% and 16.22% respectively on daily basis.The amount of strategic mineral supplement containing deficient minerals was added in the normal routine diet of advanced pregnant buffaloes. Supplementation of phosphorus, zinc and copper during gestation period of buffalo was found beneficial and has successfully prevented the occurrence of hemoglobinuria in advanced pregnant buffaloes.
Mitochondrial Inhibition by Sodium Azide Induces Assembly of eIF2α Phosphorylation-Independent Stress Granules in Mammalian Cells

Mitochondrial stress is involved in many pathological conditions and triggers the integrated stress response (ISR). The ISR is initiated by phosphorylation of the eukaryotic translation initiation factor (eIF) 2α and results in global inhibition of protein synthesis, while the production of specific proteins important for the stress response and recovery is favored. The stalled translation preinitiation complexes phase-separate together with local RNA binding proteins into cytoplasmic stress granules (SG), which are important for regulation of cell signaling and survival under stress conditions. Here we found that mitochondrial inhibition by sodium azide (NaN3) in mammalian cells leads to translational inhibition and formation of SGs, as previously shown in yeast. Although mammalian NaN3-induced SGs are very small, they still contain the canonical SG proteins Caprin 1, eIF4A, eIF4E, eIF4G and eIF3B. Similar to FCCP and oligomycine, other mitochodrial stressors that cause SG formation, NaN3-induced SGs are formed by an eIF2α phosphorylation-independent mechanisms. Finally, we discovered that as shown for arsenite (ASN), but unlike FCCP or heatshock stress, Thioredoxin 1 (Trx1) is required for formation of NaN3-induced SGs.
Cell selection to minimize power in high-performance industrial microprocessor designs

This work addresses the gate sizing and Vt assignment problem for power, area and timing optimization in modern integrated circuits (IC). The proposed flow is applied to the Benchmark Suites of the International Symposium on Physical Design (ISPD) 2012 and 2013 Contests. It is also adapted and evaluated in the post placement and post global routing stage of an industrial IC design flow using a sign-off static timing analysis engine. The proposed techniques are able to generate the best solutions for all benchmarks in the ISPD 2013 Contest (in which we were the winning team), with on average 8% lower leakage with respect to all other contestants. Also, after some refinements in the algorithms, we reduce leakage by another 10% on average over the contest results. The focus of this work is to develop and apply a state-of-the-art cell selection algorithm to further improve already optimized high-performance industrial designs after the placement and routing stages of the industrial physical design flow. We present the basic concepts involved in the gate sizing problem and how earlier literature addresses it. Several problems found when applying global optimization techniques in real-life industrial designs, which are not fully covered in publications found in literature, are presented and discussed. Considering the industrial application, the proposed techniques reduce leakage power by up to 18.2%, with average reduction of 10.4% without any degradation in timing quality.
Preparation Conditions for the Synthesis of Alkali-Activated Binders Using Tungsten Mining Waste

Partial financial support from the European Commission Horizon 2020’s MARIE Sklodowska-CURIE Research and Innovation Staff Exchange Scheme through the grant 645696 (i.e. REMINE project) is greatly acknowledged. The first author thanks, Thomas Gerald Gray Charitable Trust and Brunel University London for providing fees and a bursary to support his PhD study.
Silicon photonics temperature and refractive index sensor for curing process monitoring in composite material industry

Composite materials offer significant performance advantages due to their lightweight, high-strength, and high stiffness. This led to their adoption in several industrial sectors with particular emphasis on the aerospace industry which has undergone a transformation towards a composite-dominated new standard. In order to respond to the increased demand, it is mandatory to focus on an efficient and well-controlled curing cycle of the resin, which will lead to a significant reduction of cost and an increase in production speed. We investigate, a photonic solution, able of measure key monitoring values that facilitate optimization of the curing process. Simulation and evaluation results on a bragg grating based photonic integrated sensor, developed in 220 nm Silicon-onInsulator platform, are presented. A multi-sensor deployment is considered, enabling monitoring of the temperature and the refractive index of the resin. Serially coupled bragg grating photonic elements will enable concurrent monitoring of both temperature and refractive index. Several bragg configurations have been investigated and experimentally evaluated, specifically regular and phase-shifted ones. Both TE and TM polarization operation sensors that have been designed and fabricated, will be presented. Their sensitivity on resin temperature and refractive index variation will be discussed, resulting in a comparative study outlining the benefits and disadvantages of each solution. Refractive index sensors are realized by employing post-processing etching techniques on Multi-Project-Wafer run fabricated silicon chips, on top of the periodic bragg grating element. The comparative study takes into consideration TE and TM polarization operation, regular and phase-shifted bragg grating configuration elements, while evaluating their sensitivity in temperature and refractive index variations. Temperatures considered are in the range of 27°C to 200°C, while refractive index values lay between 1.5 and 1.6. A Figure-of-Merit is proposed to facilitate the selection of multi-sensor deployment for specific temperature and refractive index ranges.
Portugal chefs: conceção e desenvolvimento de website

PORTUGAL CHEFS CONCEÇÃO E DESENVOLVIMENTO DE WEBSITE PORTUGAL CHEFS – WEBSITE CONCEPTION AND DEVELOPMENT Maria Margarida Rodrigues Reis PALAVRAS-CHAVE: desenvolvimento web, web design, usabilidade, multimédia, produção de conteúdos, gestão de conteúdos, bases de dados, SEO, Google Analytics, media sociais, Internet
Coaching the Entrepreneur: Features and Success Factors

Purpose – Entrepreneurial coaching appears to be a sufficiently customized way to help novice owner-managers develop their managerial skills. However, its usefulness remains to be verified. The purpose of this research is thus to examine the effectiveness of coaching as a support measure for young entrepreneurs and to identify the factors likely to have an impact on the success of coaching initiatives. Design/methodology/approach – Given the exploratory nature of the study, a flexible and open approach was chosen in order to explore the concept of coaching in some depth. The strategy retained was the case study method, with inter-site comparisons of six coaching initiatives. Findings – The findings suggest that the success of a coaching relationship is explained by a set of factors or "winning conditions", some of which are more important than others. The most crucial one appears to be the entrepreneur's open attitude to change. Research limitations/implications – The main limitation of this study is the small number of cases observed. Practical implications – This research provides valuable information on coaching initiatives by means of real-life examples. It also highlights several factors likely to improve the delivery of coaching services to novice entrepreneurs. It will thus prove useful to those designing coaching programs for entrepreneurs. Originality/value – Given the lack of documentation on the subject of entrepreneurial coaching, this paper has the merit of identifying some of the elements likely to contribute to the success of coaching initiatives. In addition, its findings will fuel thinking on how to enhance the benefits of coaching for novice entrepreneurs