Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of ethanol and deferoxamine on rat primary glial cell cultures, in regard with ischemia induced by traumatic spinal cord injury

: Although they have been regarded, in the past, as passive support cells, many experimental data have shown that glial cells play a critical role in the development and functioning of the nervous system. Despite the advances that have been made in understanding astrocytes' role in the nervous system's development and function, our knowledge of their interactions with other cells is still limited, albeit neurons are dependent on the trophic support provided by astrocytes release. Materials and Methods . The use of the McCarthy and de Vellis methods for isolating glial cells has been regarded as an essential tool for studying their function. This study aims to evaluate the effects of ethanol and deferoxamine on primary rat glial cell cultures and try to explain, as far as possible, the relevance of such effects for patients with chronic alcoholism and traumatic spinal cord injuries. Discussion. Because glial cells are very important in the functioning of the central nervous system and experiments cannot be performed on human primary nerve cell cultures, we performed an experiment on glial cells harvested from the newborn rat, analyzing the dynamics of IL-6 and TNF alpha on models of suffering in spinal cord injury (hypoxia and thermally stress).
Structural and Functional Annotation of Hypothetical Protein of <i>Fusobacterium nucleatum</i> Strain MJR7757B: An in Silico Approach

Fusobacterium nucleatum is an anaerobic, commensal, gram-negative oral bacterium that is carcinogenic and causes a wide range of human diseases. The present study focused on the analysis of the hypothetical protein, HMPREF3221_01179, derived from F. nucleatum strain MJR7757B, employing various computational methods to anticipate both its structure and functional characteristics. NCBI conserved domain analysis, NCBI BLASTp and MEGA Phylogenetic tree study characterize the target protein as an outer membrane efflux protein (ToIC family) which facilitate the bacterial trans-membrane transport. With a molecular weight of 52120.02 Da, an isoelectric point (pI) of 8.33, and an instability index of 29.47, the protein is anticipated to exhibit good solubility in the extracellular space and crucial stability for pharmaceutical applications. The protein’s structure meets quality standards during the construction and refinement of its 3D model. The efflux inhibitor Arginine
The relationship between types of childbirth, body image, and sexual function in postpartum women

Background: Body image (BI) and sexual functioning can be affected by the rapid and significant physical changes that occur during pregnancy and postpartum. Objectives: This study investigated the relationship between mode of delivery, BI, and sexual function in postpartum women. Methods: This cross-sectional study was conducted between September and November 2021. A total of 203 postpartum women from five health centers in Sanandaj, Iran, were conveniently selected to enroll in this study. Data were collected using an instrument with four sections: demographic data, the Female Sexual Function Index (FSFI), and the Cash and Pruzinsky Multidimensional Body-Self Relations Questionnaire (MBSRQ). Descriptive statistics and binary logistic regression were used to analyze the data. Results: In total, 112 and 91 women had a history of normal vaginal delivery (NVD) or cesarean section (CS), respectively. Compared with the NVD group, women in the CS group had a lower MBSRQ mean (251.95±27.99 vs. 236.75±35.22) and a slightly lower FSFI mean (68.43±9.62 vs. 70.63±11.67). Age of marriage, education (none-academic), occupation (employed), method of contraception (tubectomy), husband's occupation (unemployment), number of children (3-4), FSFI score and MBSRQ score were shown as effective factors on type delivery (P≤0.05).
MIT Open Access

—We have investigated time-dependent dielectric breakdown (TDDB) in high-voltage AlGaN/GaN Metal-Insulator-Semiconductor High Electron Mobility Transistors (MIS-HEMTs), with a focus specifically on the role of temperature under positive gate stress conditions. We aim towards understanding the temperature dependence of progressive breakdown as well as hard breakdown. We find that the temperature dependence of time-to-first breakdown, hard breakdown, and the gate current evolution during progressive breakdown all share similar, shallow activation energies that suggest a common underlying mechanism. However, the gate current noise during progressive breakdown seems to be independent of temperature and is likely due to a tunneling process. Understanding of temperature-dependent breakdown is essential to developing accurate device lifetime estimates.
Digital maturity index for accounting ﬁ rms

Purpose – This study aims to develop a maturity model designed for assessing the current state of digitization inaccounting ﬁ rms. Design/methodology/approach – The authors have developed this index where the maturity levels are de ﬁ ned from the life cycle theory. For the items of a maturity measure, the authors have adopted a multimethodological approach. That approach allows to identify 27 measurement items to cover the three dimensions of audit,reportingandtaxation. Findings – This research proposes a diagnostic tool speci ﬁ c to accounting ﬁ rms. The authors have tested this index in the Tunisian context. The results show that there are two types of accounting ﬁ rms. This study found the ﬁ rst ﬁ rm in the embryonic phase and the other in the growth phase. This points out the active role of Tunisianaccounting ﬁ rmsin technologyintegration. Research limitations/implications – This study highlights the integration of technology in the accounting ﬁ eld. Speci ﬁ cally, it aims to address technology management in accounting ﬁ rms by measuring the degree of digitization of accounting ﬁ rms. This research projects the use of information technologies (arti ﬁ cial intelligence, cloud, big data, etc.) in auditing,reportingandtaxation. Practical implications – On a practical level, this research provides an organizational diagnostic tool to assess the status of their accounting ﬁ rms in terms of digitization. This will motivate practitioners to make frequentassessments,thus contributing tocontinuous improvementtowarddigitization. Originality/value – The theoretical foundation of this research is based on the theory of the life cycle of technologies. This study is using this theory to identify and describe the current phase of the organization. Andthatis by indicatingthe overall scoresonthe technological capabilitiesof the accounting ﬁ rms.
A numerical study of the inﬂuence of polydispersity on the behaviour until break of a reinforced hyperelastic material with a cohesive interface

Solid propellants manufacturers commonly monitor the granulometries of the explosive ﬁllers they introduce in the material to pack high ﬁller volume fraction and thus obtain satisfactory energetic performance. However, to our knowledge, the eﬀect of a mix of small and large particles in the micrometric size range in ﬁlled elastomers has not yet been fully understood. This work aims at producing a better understanding of the underlying mechanisms that take place in a bidisperse ﬁlled elastomer composite under uniaxial loading by using ﬁnite element simulations. An original process for creating bidisperse microstructures is proposed and analyzed. The key role of the ﬁller/matrix interface is emphasized through the use of a cohesive zone model. Plane-strain simulations in uniaxial tension of such cells with diﬀerent fractions of large and small particles are performed.
Does Generosity Generate Generosity? An Experimental Study of Reputation Effects in a Dictator Game

This paper explores how information about paired subject's previous action affects one's own behavior in a dictator game. The first experiment puts dictators in two environments where they can either give money to the paired player or take money away from them: one where the recipient is a stranger and the other where the dictator has information on the recipient's reputation. Contrary to anecdotal evidence, the statistical tests show that the dictator's behavior toward a stranger is not statistically significantly different from their behavior toward an individual with an established reputation. The findings arise because a high proportion of dictators acted purely in their own self interest in both treatments. In the second experiment the dictators' choices were restricted to only generous actions. In such environment the dictators sent more money on average to recipients with a reputation for being generous than to recipients without a reputation.
Detección de radionucleidos cosmogénicos mediante la técnica de espectrometría de masas con aceleradores

Una extensa variedad de radionucleidos son producidos por la interaccion de los rayos cosmicos de alta energia con la atmosfera de nuestro planeta y con el polvo interplanetario que eventualmente puede arribar a el. Entre estos radionucleidos se encuentran el 10Be (T1/2 ~ 1,4 x 10^6 a˜nos) y el 53Mn (T1/2 ~ 3,7 x 10^6 a˜nos), que gracias a sus largos periodos de semidesintegracion, resultan adecuados como trazadores en procesos de interes geofisico cuyos tiempos caracteristicos son del orden de los millones de a˜nos. Ademas, el 53Mn, por producirse esencialmente fuera de nuestro planeta, es un excelente trazador de la depositacion de material extraterrestre sobre la Tierra. Debido a sus concentraciones, de una parte en 10^9 hasta una parte en 10^15 respecto de sus isotopos estables, y actividades especificas extremadamente bajas, estos radionucleidos solo pueden ser identificados y cuantificados mediante la tecnica de espectrometria de masas con aceleradores (AMS). En este trabajo se aplico la tecnica AMS para la deteccion de estos radionucleidos con el objeto de estudiar el reciclado de sedimentos submarinos durante la subduccion de placas tectonicas y la tasa de depositacion de polvo interplanetario en nuestro planeta. En el primer caso las muestras analizadas fueron cenizas y rocas volcanicas y sedimentos extraidos de hasta 250 metros de profundidad por debajo del fondo submarino. En el segundo caso, se analizo una muestra de 1.400 kg de nieve antartica. Todas las muestras fueron procesadas quimicamente para la extraccion y concentracion del elemento de interes y la supresion del isobaro que interfiere en las mediciones de AMS. Las mediciones de las relaciones isotopicas fueron llevadas a cabo utilizando cuatro aceleradores de diferentes laboratorios, aprovechando las ventajas tecnicas de cada uno. Finalmente, mediante el modelado de estos procesos y sobre la base de los resultados obtenidos fue posible determinar rangos para el porcentaje de sedimentos submarinos que participan de la formacion de magmas durante la subduccion de la placa tectonica de Nazca y establecer una cota superior para la cantidad de polvo interplanetario que ingresa a nuestro planeta. Ademas de estas dos aplicaciones geofisicas, en el marco de este trabajo se implemento la tecnica AMS en las instalaciones del Acelerador TANDAR de forma cuantitativa. Para ello se construyo un sistema de deteccion que, haciendo uso de las altas energias posibles en este acelerador, permitio la identificacion del radionucleido 10Be con la completa supresion de su isobaro estable 10B. De este modo, se consiguieron en el Acelerador TANDAR, mediciones de relaciones isotopicas 10Be/9Be tan bajas como 5 x 10^−13, nivel de sensibilidad suficiente para realizar la mayoria de los estudios geofisicos con este radionucleido.
The cost of myopic pandemic response

Prior to the availability of COVID-19 vaccines, non-pharmaceutical interventions (NPIs) served as a primary strategy to mitigate the spread of the disease. However, the efficiency of these interventions relies on understanding and incorporating human behavior into infectious disease models. This study addresses the need for models that better account for the influence of temporal discounting on behavioral dynamics to enhance forecasting accuracy and develop robust mitigation strategies. Our previous research introduced Known Time Horizon (KTH) policies, optimizing social distancing measures based on a central planner's rational assessment of the pandemic's time frame and associated costs. In this paper, we contrast the KTH policy with a model reflecting myopic decision-making, an extreme form of temporal discounting that emphasizes short-term outcomes over long-term consequences. By comparing the expected social distancing behavior under myopic decision-making with the optimal policy derived from KTH approaches, we elucidate the impact of temporal bias on social distancing practices and assess its implications for infection dynamics and associated costs. We find that myopic policy always results in greater total costs throughout an epidemic compared to a KTH policy. However, each cost component -- the costs of infection and social distancing -- derived from a myopic strategy may be either larger or smaller than the component costs for a strategy developed using a full optimization model, depending on the specific parameters involved as myopic decision-makers seek to delay both costs of social distancing and infection.
An Approach to Detect Clones in Class Diagram Based on Suffix Array

Copy-paste is becoming a very usual practice in software development. Copying a code in one or more place without any change is mainly known as software cloning and the pasted part of code is called clone. Clones in code increase the maintenance cost, resource requirements and make code more error prone. So detection and removal of clone is very important for source code. Models are also affected by the cloning problem. Model Driven Engineering now becomes a standard and important framework in software research area. Unpredicted copy of model elements leads to various difficulties. Models consists design level similarities and are in the same way harmful for software maintenance as code clones are. Therefore, clones are required to be identified from models. Class diagram is the main aspect of modeling and used to describe the static view of an application. Class diagram contains redundant elements which increase complexity of the class diagram as well as maintenance effort. Code quality can be improved if clones are detected from the class diagram. Current work aims to find clones in class diagram using an approach based on suffix array. Firstly, diagram is encoded as XML file and then tokens are extracted. Suffix array is used to compare tokens and matched tokens are known as clones. Keywords— clone; code clones; model clones; class diagram; complexity; Suffix array.
Relationship between the Asian Westerly Jet Stream and Summer Rainfall over Central Asia and North China: Roles of the Indian Monsoon and the South Asian High

AbstractDiagnostic analyses are performed to investigate the relationship between the upper-level Asian westerly jet stream (AWJS) and the associated rainfall pattern over the AWJS region in boreal summer on interannual time scales. Results show an out-of-phase rainfall variation over central Asia (CA) and north China (NC), which is closely related to the southeast–northwest (SE–NW) shift of the AWJS. The physical mechanisms on the relationship between the AWJS and the rainfall pattern are revealed by exploring the effects of the Indian summer monsoon (ISM) and the South Asian high (SAH). It is found that the SE–NW shifts of the AWJS and SAH associated with the ISM lead to the anomalous circulations over the midlatitudes in the AWJS region and cause rainfall anomalies over CA and NC. A weak ISM results in a southeastward shift of SAH, which is responsible for a southeastward shift of the AWJS. The anomalous atmospheric circulation associated with the southeastward located SAH produces anomalous updrafts (.
Adults’ perceived health promotion needs in the prediabetes stage: a meta-synthesis study

Summary Introduction One of the methods to promote pre-diabetic patients’ adherence to preventive behaviors and improving their lifestyle is to pay attention to their needs in the designed educational programs. Therefore, this study was conducted with the aim of identifying the needs of individuals with prediabetes. Methodology Three databases, including ISI/Web of Sciences, PubMed, Scopus were searched without time limitation until August 2022. The quality of the included studies was assessed using the Critical Appraisal Skills Programme tool. This study was reported according to the Enhancing Transparency in Reporting the Synthesis of Qualitative Research guidelines and to achieve the research goal, Sandelowski and Barroso’s seven-step meta-synthesis method (2007) was used. Thematic synthesis was used to analyses the data. Results Out of the 1934 studies obtained, 34 studies were finally examined and 805 codes were recorded based on the extracted data. Through synthesizing and analyzing the primary studies, 8 main themes were extracted regarding individuals’ needs in the prediabetes stage: Information needs, Cultural needs, psychological needs, Social support needs, Education needs, Financial needs, Service needs and Skill needs. Discussion and Conclusions The perceived needs and their types in each of the dimensions in detail can be a proper guide for designing educational programs and various interventions to control the prediabetes condition, leading to a reduction in the prevalence of type 2 diabetes in the society.
Stem Cell Repor ts

SUMMARY Regeneration of neurons has important implications for human health, and the retina provides an accessible system to study the poten-tialof replacingneuronsfollowinginjury. In previouswork, wegeneratedtransgenicmice inwhichneurogenictranscriptionfactorswere expressed in Mu¨ller glia (MG) and showed that they stimulated neurogenesis following inner retinal damage. It was unknown, however, whether the timing or mode of injury mattered in this process. Here, we explored these parameters on induced neurogenesis from MG and show that MG expressing Ascl1 will generate new bipolarneurons with similar efﬁciency irrespective of injury mode or timing. However, MG that express Ascl1-Atoh1 produce a new type of retinal ganglion-like cell after outer retinal damage, which is absent with inner retinal damage. Our data suggest that although cell fate is primarily dictated by neurogenic transcription factors, the inﬂammatory state of MG relative to injury can inﬂuence the outcome of induced neurogenesis.
Improving oil contaminated soil characteristics through the use of combined treatments necessary for phytoremediation technologies

The objective of this study was to determine the possibility of using fly ash amendment optimal doses from a thermal plant, mixed with a fertilizer agent, anaerobically stabilized sewage sludge to reduce stress caused by the presence of large amounts of 113.5 g·kg D.M. of oil product, TPH, (Total Petroleum Hydrocarbons) in polluted soils. The study was conducted in vegetation pots to determine the emergence degree and development of a culture of forage leguminous plants of Lotus corniculatus species, bird’s foot trefoil. The experimental variants were treated with fly ash and fertilized with 500g per vegetation pot of anaerobically stabilized sewage sludge. Studies were done in comparison with experimental versions cultivated with bird’s foot trefoil of polluted soil treated with fly ash, polluted soil fertilized untreated with ash. The addition of fertilizing agent mixed with small amount of fly ash caused a emergence degree of 50-60%, and the reduction of the content of oil product, after 4 months of vegetation, by 29.9%. The maintaining of vegetation in perennial regime specific to this plant species demonstrates the plant tolerance to conditions created by the treatment of polluted soil with adequate amounts of fertilizer and fly ash amendment,
Airway epithelial cell response to RSV is mostly impaired in goblet and multiciliated cells in asthma.

BACKGROUND In patients with asthma, respiratory syncytial virus (RSV) infections can cause disease exacerbation by infecting the epithelial layer of the airways, inducing subsequent immune response. The type I interferon antiviral response of epithelial cells upon RSV infection is found to be reduced in asthma in most-but not all-studies. Moreover, the molecular mechanisms causing the differences in the asthmatic bronchial epithelium in response to viral infection are poorly understood. METHODS Here, we investigated the transcriptional response to RSV infection of primary bronchial epithelial cells (pBECs) from patients with asthma (n=8) and healthy donors (n=8). The pBECs obtained from bronchial brushes were differentiated in air-liquid interface conditions and infected with RSV. After 3 days, cells were processed for single-cell RNA sequencing. RESULTS A strong antiviral response to RSV was observed for all cell types, for all samples (p<1e-48). Most (1045) differentially regulated genes following RSV infection were found in cells transitioning to secretory cells. Goblet cells from patients with asthma showed lower expression of genes involved in the interferon response (false discovery rate <0.05), including OASL, ICAM1 and TNFAIP3. In multiciliated cells, an impairment of the signalling pathways involved in the response to RSV in asthma was observed. CONCLUSION Our results highlight that the response to RSV infection of the bronchial epithelium in asthma and healthy airways was largely similar. However, in asthma, the response of goblet and multiciliated cells is impaired, highlighting the need for studying airway epithelial cells at high resolution in the context of asthma exacerbation.
Gelebter Raum Stadtlandschaft: Taktiken für Interventionen an suburbanen Orten

Wie lassen sich Stadtlandschaften verstehen und gestalten? Der Band bereichert den theoretischen Diskurs über verstädterte Landschaften um neue Perspektiven für die Praxis: Ausgehend vom Konzept des »gelebten Raumes« von Henri Lefèbvre und Karlfried von Dürckheim widmet sich Jörg Heiler den komplexen Beziehungen zwischen Mensch und Raum in der suburbanen Landschaft. Er zeigt konkrete Handlungsmöglichkeiten auf und gibt wichtige Impulse dafür, vormals »unentdeckte« Stadtlandschaften der Öffentlichkeit zugänglich zu machen, ihre sinnlich-leibliche Wahrnehmbarkeit zu fördern und ihre architektonisch-situativen Qualitäten zu steigern.