Miracle-dz/UniFAR-FTUs huggingface dataset:
Cerebral Cavernous Malformation: Immune and Inflammatory Perspectives

Cerebral cavernous malformation (CCM) is a type of vascular anomaly that arises due to the dyshomeostasis of brain capillary networks. In the past two decades, many advances have been made in this research field. Notably, as a more reasonable current view, the CCM lesions should be attributed to the results of a great number of additional events related to the homeostasis disorder of the endothelial cell. Indeed, one of the most fascinating concerns in the research field is the inflammatory perturbation in the immune microenvironment, which would affect the disease progression as well as the patients’ outcomes. In this work, we focused on this topic, and underlined the immune-related factors’ contribution to the CCM pathologic progression.
Early Prediction of Dental Caries using Hormonal Fingerprint in 6–12 Years Old Children: A Cross-sectional Study

Abstract Background The ratio between second and fourth digit lengths (2D:4D ratio) is termed as hormonal fingerprint. Second and fourth digit lengths ratio is used as a biological marker for predicting and diagnosis of many metabolic disorders mainly coronary heart disease and autism, whereas, in dentistry, this method is still in blooming stage. The aim of the study was to assess the relationship between the new biological marker–hormonal fingerprints in the early detection of caries in children. Methodology A total of 250 children were randomly selected from both sexes of the age group 6–16 years. Caries assessment was done using standard mouth mirrors and community periodontal index probes. Caries status (deft and DMFT) was recorded and subjects with a total DMFT/deft score of >5 were considered to have a high caries rate. The hormonal fingerprint was made by measuring the length ratio of the index and ring finger with the help of vernier caliper. The entire study population was divided into children with 2D:4D ratio less than 1 and ≥1 based on the calculations of 2D:4D. Results The results showed that 79.67% males and 29.92% females have 2D:4D ratio <1 and 70.07% females and 20.32% males have 2D:4D ≥1. There is negative correlation between caries incidence and 2D:4D ratio. Children with low 2D:4D ratio have high caries index (54.4%) and high 2D:4D ratio have low caries index (45.6%), which is statistically significant. Conclusion The study confirms a positive correlation between low 2D:4D ratio and high caries, which could be used as an early biological predictor of dental caries. How to cite this article Beegum F, Khan N, George S, et al. Early Prediction of Dental Caries using Hormonal Fingerprint in 6–12 Years Old Children: A Cross-sectional Study. Int J Clin Pediatr Dent 2022;15(3):247-250.
Decellularized Extracellular Matrix for Tissue Engineering (Review)

In recent years, decellularized tissues have evolved into a new, full-fledged platform for the creation of tissue-engineered constructions. Extracellular matrix (ECM) of each tissue provides a unique tissue-specific microenvironment for resident cells with the structure and biochemical signaling required for their functioning. The decellularized ECM (dECM) has been established to influence cell differentiation. The review provides recent data on the composition and functions of the ECM, methods for obtaining decellularized tissues, and their application in tissue engineering depending on their physical form (scaffold, powder, or hydrogel). The effect of the matrix source, decellularization and sterilization techniques on dECM composition has been considered. Regulatory mechanisms of cell differentiation by the extracellular matrix are discussed. Differences in the protein composition of the native and decellularized materials are presented. Application of dECM in the bioink composition for regeneration of various tissues using bioprinting technologies is also considered. It has been concluded that successful application of dECM in tissue engineering and regenerative medicine requires a permanent and biologically suitable dECM source, optimized tissue decellularization protocols, improved mechanical properties of dECM-derived bioinks, and prevention of immunological reaction of the organism.
The Mechanism of Adsorbents Adsorption Affinity in Relation to Geometric Parameters

In the process of incorporating adsorption with thermal desalination, adsorbents are important because they increase the water vapour uptake rate, and this would yield more desalinated water over a short period. Therefore, they are important and the key parameters in the selection of adsorbent for an adsorption desalination (AD) cycle are thermo-physical properties, surface characteristics and water vapor uptake capacity. The best adsorbent is used as the adsorbent-refrigerant pair and is driven at 50 oC to 85 oC by low-temperature heat sources. When the unsaturated adsorbent is exposed to vapour in the evaporator, the uptake of vapor is accelerated by the high affinity of the water molecules to the silica gel pores. Likewise, when the same adsorbent is heated thermally, the water vapor molecules are removed or desorbed from the adsorbent pores to the cooler surfaces of the condenser tubes, producing high-grade water during the phase. Key words: Desalination; Porosity; Adsorption isotherm; Geometric parameters. Sorption Phenomenon
Characterization and phylogenetic analysis of the complete mitochondrial genome of the firemouth cichlid, Thorichthys meeki (Perciformes: Cichlidae)

Abstract Here, we report information on the complete mitochondrial genome of the firemouth cichlid, Thorichthys meeki (Brind 1918). Illumina HiSeq genome sequencing produced the assembly of a circular mitogenome of 16,527 base pairs (bp) from T. meeki consisting of 46.8% GC nucleotides, 13 protein-coding genes (PCGs), two ribosomal RNA (rRNA) genes, 22 transfer RNA (tRNA) genes, and a putative control region as shown in the typical teleost gene composition. The gene order of the T. meeki mitogenome was identical to that of other cichlid species. A maximum likelihood phylogenetic tree based on mitochondrial PCGs showed a close relationship of T. meeki with Thorichthys aureus (Gunther 1862) within Heroini tribe.
Host HSPD1 Translocation from Mitochondria to the Cytoplasm Induced by Streptococcus suis Serovar 2 Enolase Mediates Apoptosis and Loss of Blood–Brain Barrier Integrity

Streptococcus suis serovar 2 (S. suis serovar 2) is a zoonotic pathogen that causes meningitis in pigs and humans, and is a serious threat to the swine industry and public health. Understanding the mechanism(s) by which S. suis serovar 2 penetrates the blood–brain barrier (BBB) is crucial to elucidating the pathogenesis of meningitis. In a previous study, we found that expression of the virulence factor enolase (Eno) by S. suis serovar 2 promotes the expression of host heat shock protein family D member 1 (HSPD1) in brain tissue, which leads to the apoptosis of porcine brain microvascular endothelial cells (PBMECs) and increased BBB permeability, which in turn promotes bacterial translocation across the BBB. However, the mechanism by which HSPD1 mediates Eno-induced apoptosis remains unclear. In this study, we demonstrate that Eno promotes the translocation of HSPD1 from mitochondria to the cytoplasm, where HSPD1 binds to β-actin (ACTB), the translocated HSPD1, and its interaction with ACTB led to adverse changes in cell morphology and promoted the expression of apoptosis-related proteins, second mitochondria-derived activator of caspases (Smac), and cleaved caspase-3; inhibited the expression of X-linked inhibitor of apoptosis protein (XIAP); and finally promoted cell apoptosis. These results further elucidate the role of HSPD1 in the process of Eno-induced apoptosis and increased BBB permeability, increasing our understanding of the pathogenic mechanisms of meningitis, and providing a framework for novel therapeutic strategies.
Incidence of New-onset Atrial Fibrillation in Patients Presenting with Acute St-elevation Myocardial Infarction

Aim: This study aims to find out the incidence of atrial fibrillation new onset in STEMI patients receiving primary PCI Sample: A total of 169 patients have included after sample size calculation by using WHO sample size calculator version 2.0. Study Design: Descriptive cross-sectional study Place and Duration of Study: This study was conducted at the Department of Interventional Cardiology at the National Institute of Cardiovascular Disease (NICVD), Karachi, Pakistan from April 18th, 2020, to October 17, 2020. Methodology: The inclusion criteria set for data collection were as; all the patients undergoing Primary PCI with age between 40 to 80 years, males and females, patients presented with 12 hours of the onset of chest pain with STEMI to enroll in the study. Whereas, patients who had a previous history of any cardiac-related surgery and known AF, also all the patients suffered AF after trial of cardioversion, and those patients who had ejection fraction less than 20% were excluded from the study. Result: The demographic classification showed the mean age of the patients was 55.96±8.9 with a CI of 54.60 to 57.33 years. The mean height of the patients was 167.34±0.56 with CI of 166.2 to 168.46. The mean weight of the patients was 74.84±0.7 with CI of 73.39 to 76.29 kg. The average BMI of all the patients was 26.7±0.28 with CI of 26.2 to 27.33. The analysis of the data revealed that Atrial fibrillation is more common in people who don’t smoke tobacco and are non-diabetic. Diabetic patients are less prone to atrial fibrillation in MI. Conclusion: The prevalence of new-onset of atrial fibrillation was found to be high in elderly age group patients.
DFT Analysis of Hole Qubits Spin State in Germanium Thin Layer

Due to the presence of a strong spin–orbit interaction, hole qubits in germanium are increasingly being considered as candidates for quantum computing. These objects make it possible to create electrically controlled logic gates with the basic properties of scalability, a reasonable quantum error correction, and the necessary speed of operation. In this paper, using the methods of quantum-mechanical calculations and considering the non-collinear magnetic interactions, the quantum states of the system 2D structure of Ge in the presence of even and odd numbers of holes were investigated. The spatial localizations of hole states were calculated, favorable quantum states were revealed, and the magnetic structural characteristics of the system were analyzed.
Building rooftop classification using random forests for large-scale PV deployment

Large scale solar Photovoltaic (PV) deployment on existing building rooftops has proven to be one of the most efficient and viable sources of renewable energy in urban areas. As it usually requires a potential analysis over the area of interest, a crucial step is to estimate the geometric characteristics of the building rooftops. In this paper, we introduce a multi-layer machine learning methodology to classify 6 roof types, 9 aspect (azimuth) classes and 5 slope (tilt) classes for all building rooftops in Switzerland, using GIS processing. We train Random Forests (RF), an ensemble learning algorithm, to build the classifiers. We use (2 × 2) [m2 ] LiDAR data (considering buildings and vegetation) to extract several rooftop features, and a generalised footprint polygon data to localize buildings. The roof classifier is trained and tested with 1252 labeled roofs from three different urban areas, namely Baden, Luzern, and Winterthur. The results for roof type classification show an average accuracy of 67%. The aspect and slope classifiers are trained and tested with 11449 labeled roofs in the Zurich periphery area. The results for aspect and slope classification show different accuracies depending on the classes: while some classes are well identified, other under-represented classes remain challenging to detect.
Regulation of SUMOylation Targets Associated With Wnt/β-Catenin Pathway

Wnt/β-catenin signaling is a delicate and complex signal transduction pathway mediated by multiple signaling molecules, which plays a significant role in regulating human physiology and pathology. Abnormally activated Wnt/β-catenin signaling pathway plays a crucial role in promoting malignant tumor occurrence, development, recurrence, and metastasis, particularly in cancer stem cells. Studies have shown that the Wnt/β-catenin signaling pathway controls cell fate and function through the transcriptional and post-translational regulation of omics networks. Therefore, precise regulation of Wnt/β-catenin signaling as a cancer-targeting strategy may contribute to the treatment of some malignancies. SUMOylation is a post-translational modification of proteins that has been found to play a major role in the Wnt/β-catenin signaling pathway. Here, we review the complex regulation of Wnt/β-catenin signaling by SUMOylation and discuss the potential targets of SUMOylation therapy.
Comparison of Pure and Crossbred Japanese Black Steers in Growth Performance and Metabolic Features from Birth to Slaughter at a Spanish Fattening Farm

Simple Summary Cattle growth performance is a determinant of beef production. Nowadays, customers demand specialized, high-quality beef products produced according to stringent health and welfare standards. Intramuscular fat, or marbling, improves beef quality, and the Japanese Black (Wagyu) is the breed with the highest rates of marbling. Wagyu steers are reared under specific conditions in Japan, which may differ from the conditions in other countries, and these differences may affect animal well-being and, therefore, growth rates and beef quality. The current study shows that purebred Wagyu and crossbred Wagyu-by-Angus steers that were raised at a cow–calf operation and fattening system in Spain with no exercise restriction, high welfare, and a local diet high in olein content showed appropriate growth and fattening rates, health status, and metabolic development. Wagyu crossbred steers did not show substantially faster growth than purebred Wagyu animals, so they may not be as profitable as purebred Japanese Black in this type of production system. Abstract Japanese Black (Wagyu) cattle produce high-quality beef. However, whether Wagyu steers can be profitably raised under conditions different than the traditional Japanese ones remains unclear. From 2018 to 2020, we raised 262 Wagyu purebred steers, 103 Wagyu-by-Angus (Wangus) crossbred steers, and 43 Angus-by-European (ACL) crossbred steers on a Spanish farm with high welfare standards and a locally sourced, high-olein diet. Factors and factors’ interactions impacting steer growth were analyzed using generalized linear models. ACL steers grew faster than the other two groups, with Wangus showing intermediate fattening and muscle development. Average daily weight gains (kg/day) were 0.916 for Wagyu, 1.046 for Wangus, and 1.293 for ACL during the weaning to growing period, and 0.628 for Wagyu, 0.64 for Wangus, and 0.802 for ACL during the growing to fattening phase. ACL showed the lowest marbling rates. Wagyu and Wangus usually showed higher cholesterol, triglycerides, and high-density lipoprotein than ACL. ACL calves may experience greater stress at weaning, as suggested by higher glucose, lactate, and β-hydroxybutyrate than the other groups. The results suggest that Wagyu and Wangus steers showed adequate growth, health, and metabolic development in this type of production system, with Wagyu purebreds probably being more profitable than Wangus crossbreeds.
Evaluation of Food Labelling the Products with Information Regarding the Level of Sugar: A Preliminary Study

The aim of this article is to explore the reasons for seeking selected information on a food label, with particular emphasis on certain information about sugar. In order to meet the aim, in 2020, a survey was conducted among consumers aged 18–45. Predictive models (Logistic Regression) were developed for noticing “light” products and reading food labels. The results of our study indicate that consumers are mainly discouraged from reading label information by a large amount of information, the lack of time, and a general reluctance to be interested in label information. When it comes to the factors that lead people to read label information, the naturalness of the product, its organic origin, and physical activity are important. Moreover, respondents who declared that they noticed products on the market defined as “light” were those who were interested in the naturalness of the product, but also consumers declaring that they have nutritional knowledge. The results of the study indicate the need to intensify information campaigns in order to emphasize how important it is for consumers to read the information on food labels. The amount and complexity of information currently appearing on the food label may unfortunately discourage consumers from reading it, so it is important to continuously improve this form of communication with the consumer.
Registros notables de mamíferos en una cordillera aislada, amenazada y no protegida en la depresión de Huancabamba, norte de Perú

La depresión de Huancabamba es la sección más baja de todos los Andes y tiene una importancia biogeográfica muy significativa para la biodiversidad andina del sur de Ecuador y norte de Perú. Solo algunas montañas o cordilleras en esta depresión sobrepasan los 3.000 m s.n. m. y se encuentran relativamente aisladas. Los estudios de mamíferos de la zona aún son escasos. En este artículo detallamos las especies más notables de mamíferos medianos y mayores, así como la riqueza preliminar de los taxones registradas mediante cámaras trampa (3.847 cámaras-día) y observaciones en los bosques montanos y jalcas de Tucto y Gramalote, ubicados en la cordillera Kañaris – Pagaibamba en el departamento de Cajamarca, noroeste de Perú. De las 14 especies de mamíferos registrados, dos son especies globalmente amenazadas (Tapirus pinchaque y Tremarctosornatus), una está casi amenazada (Cuniculus taczanowskii) y dos aparecen con datos deficientes (Dasypus pilosus y Sylvilagus andinus). Reportamos una ampliación de la distribución de D. pilosus, los registros documentados a mayor altitud de Dasyprocta cf. fuliginosa y Potos flavus, y una ampliación del rango altitudinal de Coendou rufescens en el país. Este último constituye, además, el primer registro de la especie en el departamento de Cajamarca. Asimismo, hemos encontrado una importante población de T. ornatus en el área, una abundancia relativa de T. pinchaque en el extremo sur de su distribución global, con registros directos más actuales. Nuestro estudio evidenció que la cordillera Kañaris - Pagaibamba constituye un singular refugio para mamíferos andinos que es urgente proteger.
Tackling Multiple-Drug-Resistant Bacteria With Conventional and Complex Phytochemicals

Emerging antibiotic resistance in bacteria endorses the failure of existing drugs with chronic illness, complicated treatment, and ever-increasing expenditures. Bacteria acquire the nature to adapt to starving conditions, abiotic stress, antibiotics, and our immune defense mechanism due to its swift evolution. The intense and inappropriate use of antibiotics has led to the development of multidrug-resistant (MDR) strains of bacteria. Phytochemicals can be used as an alternative for complementing antibiotics due to their variation in metabolic, genetic, and physiological fronts as well as the rapid evolution of resistant microbes and lack of tactile management. Several phytochemicals from diverse groups, including alkaloids, phenols, coumarins, and terpenes, have effectively proved their inhibitory potential against MDR pathogens through their counter-action towards bacterial membrane proteins, efflux pumps, biofilms, and bacterial cell-to-cell communications, which are important factors in promoting the emergence of drug resistance. Plant extracts consist of a complex assortment of phytochemical elements, against which the development of bacterial resistance is quite deliberate. This review emphasizes the antibiotic resistance mechanisms of bacteria, the reversal mechanism of antibiotic resistance by phytochemicals, the bioactive potential of phytochemicals against MDR, and the scientific evidence on molecular, biochemical, and clinical aspects to treat bacterial pathogenesis in humans. Moreover, clinical efficacy, trial, safety, toxicity, and affordability investigations, current status and developments, related demands, and future prospects are also highlighted.
Machine Learning Approaches for Developing Land Cover Mapping

In remote sensing data processing, cover classification on decimeter-level data is a well-studied but tough subject that has been well-documented. The majority of currently existent works make use of orthographic photographs or orthophotos and digital surface models that go with them (DSMs). Urban land cover classification plays a significant role in the field of remote sensing to enhance the quality of different applications including environment protection, sustainable development, and resource management and planning. Novelty of the research done in this area is focused on extracting features from high-resolution satellite images to be used in the classification process. However, it is well known in machine learning literature that some of the extracted features are irrelevant to the classification process with a negative or no effect on its accuracy. In this work, a genetic algorithm-based feature selection approach is used to enhance the performance of urban land cover classification. Neural networks (NNs) and random forest (RF) classifiers were used to evaluate the proposed approach on a recent urban land cover dataset of nine different classes. Experimental results show that the proposed approach achieved better performance with RF classifier using only 27% of the features. The random forest tree has achieved highest accuracy 84.27%; it is concluded that the RF algorithm is an appropriate algorithm for classifying cover land.
Fraturas intracapsulares do colo femoral no idoso

Atualmente, a fratura intracapsular do colo femoral (FICF) ainda é um grande desafio para os ortopedistas. Apesar dos grandes avanços feitos, persiste uma grande taxa de mortalidade no primeiro ano, sobretudo no Brasil, onde não há uma conscientização de que tais fraturas nos pacientes idosos devem ser tratadas como uma urgência médica. O presente artigo busca fornecer uma atualização das condutas pré-operatórias, cirúrgicas e pós-operatórias.