Miracle-dz/UniFAR-FTUs huggingface dataset:
Structure of Microvascular Networks in Genetic Hypertension

Microvascular rarefaction, defined by a loss of terminal arterioles, small venules and/or capillaries, is a common characteristic of the hypertension syndrome. While rarefaction has been associated with vessel specific free radical production, deficient leukocyte adhesion, and cellular apoptosis, the relationships of rarefaction with structural alterations at the network and cellular level remain largely unexplored. The objective of this study was to examine the architecture and perivascular cell phenotypes along microvascular networks in hypertensive versus normotensive controls in the context of imbalanced angiogenesis. Mesenteric tissues from age-matched adult male spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats were harvested and immnolabeled for PECAM and neuron-glia antigen 2 (NG2). Evaluation of intact rat mesenteric microvascular networks rats suggests that network alterations associated with hypertension are more complex than just a loss of vessels. Typical SHR versus WKY networks demonstrate a reduced branching architecture marked by more proximal arteriole/venous anastomoses and an absence of NG2 labeling along arterioles. Although less frequent, larger SHR microvascular networks display regions of dramatically increased vascular density. SHR and WKY lymphatic networks demonstrate increased vessel diameters and vascular density compared to networks in normotensive Wistar rats (the strain from which both the SHR and WKY originated). These observations provide a rationale for investigating the presence of local angiogenic factors and response of microvascular networks to therapies aimed at reversing rarefaction in genetic hypertension.
The Construction of a Class of Stationary Markoff Processes

An arrangement for sintering under vacuum pressed powder elements which contain hydrocarbons. The hydrocarbons are driven out under lower pressure and higher temperature than ambient conditions. A flow of cleansing gas is then directed between the periphery of the pressed powder elements and the device for separating the hydrocarbons. This process step is carried out at a temperature between 100 DEG and 800 DEG C. , while the pressure is below atmospheric. The sintering operation is then carried out after the hydrocarbons have been substantially driven out.
OF COMBINED CO 2 -EOR AND CCS PROJECTS BASED ON THE EXAMPLE OF A POLISH MULTILAYERED OIL FIELD

The article presents a comprehensive economic analysis of a CO 2 injection project in one of the Po- lish oil fields for both increased production (CO 2 -EOR) and underground storage (CCS). An interesting differentiator of this work is the use of a multilayered reservoir, which is actually not one reservoir but several located in the same place, as an example. It allows the optimization of the processes of injection, production and storage. Such projects are becoming more and more important because recently, after a period of long-term stagnation, costs of carbon allowances have started to rise which affects e.g. the electricity market in Poland. This can be an important incentive for the development of CCS technology, especially in combination with CO 2 -EOR. In the case of very high costs of carbon emissions rights CCS may turn out to be a cheaper solution. Economic efficiency is the main determinant of the EOR project’s success, as well as a very significant factor influencing the potential development of CO 2 underground storage. Results are based on the numerical simulation of a combined CO 2 -EOR and CCS project. This analysis has been divided into two parts. The first uses a standard, deterministic approach, based on the DCF method and NPV indicator. It also provides a detailed sensitivity analysis, with particular reference to the impact of oil prices and the cost of carbon emissions rights on a project’s profitability. The second part of the economic analysis is probabilistic and involves estimating the maximum amount of CAPEX using the Monte Carlo method. Two cases were taken into account. The first assumes that the CO 2 emitter pays for CO 2 storage and the price is equal to 80% of the emissions rights price (with storage revenue). In the second one the emitter does not pay for storage (without storage revenue).
Determination of Nutritional Status of Olive ( Olea europaea L.) Trees Grown in Izmir and Mugla Province in Terms of Boron and The Other Microelements with Soil and Leaf Analyzes

This study was conducted to determine the nutritional status of olive cultivated land and olive plant in Izmir and Mugla province in terms of boron and other elements. For this purpose, 254 soil samples (0-30 cm depth) and 254 leaf samples were taken simultaneously with GPS coordinates from the olive production areas and analyzed (125 gardens in Datca, Koycegiz, Milas, Ula, Seydikemer districts of Mugla province / 129 gardens in Aliaga, Bayindir, Bergama, Dikili, Foca, Karaburun, Kemalpasa, Menderes, Menemen, Odemiş, Seferihisar, Selcuk, Tire, Torbali and Urla district of Izmir province). In the soil samples texture, pH, EC, lime, organic matter, extractable boron, iron, copper, zinc and manganese analysis were done. In the leaf samples total boron, iron, copper, zinc and manganese content were determined. According to the analysis results, the nutritional studies of olive were determined in term of boron and other elements. According to the results of the research, boron contents of the research areas soils ranged between 0.20 and 5.24 mg kg -1 and the average level was determined as 1.21 although 85.83% of the soils have sufficient boron, 85.04% of the leaves show boron deficiency, indicating that boron nutritional problems are experienced. Also according to the results of analysis, it was determined that there were no nutritional problems in terms of iron, and that there were serious nutritional problems in terms of boron and zinc. It was determined that nutritional problems in term of manganese and copper slightly. As with all plant species, fertilization programs for olive plant should be established according to soil and leaf analysis result. According to the results of analysis, it is important to give the deficient macro and micronutrients in addition to phosphorus, nitrogen and potassium fertilizers which will be given with basic fertilization.
A frequency reconfigurable antenna for multiband mobile handset applications

A frequency‐reconfigurable antenna is presented for multiband (GSM850/900/GLONASS1616/DCS1800/PCS 1900/UMTS/LTE2300/2500/WLAN) mobile handset applications. It mainly consists of radiating elements with two PIN diodes. By switching the ON/OFF states of the PIN diodes, the proposed structure can operate in three states: OFF–ON, ON–OFF, and ON–ON. When PIN diodes are in the OFF–ON states, the proposed antenna can cover the GSM850/900, PCS1900, and UMTS2100 bands by operating in Invented‐F antenna (IFA) mode. When PIN diodes are in the ON–OFF states, the antenna can cover the LTE2300/2500 and WLAN2400 bands in monopole mode. Moreover, when PIN diodes are switched to the ON–ON states, the designed antenna works in loop mode and its resonant frequencies include the GLONASS1616, DCS1800/1900, and LTE2500 bands. With the reconfigurable technique, the proposed antenna achieves a compact size of 15 × 28.5 mm2 with high efficiency from 34% to 84.86% in the total frequency range.
The Gene for the ca Subunit of Human Guanine Nucleotide Binding Protein Maps near the Cystic Fibrosis Locus

Summary The gene for the oi1 subunit of human guanine nucleotide binding (G) protein was mapped by in situ hybridization to chromosome 7 at band q21. The regional chromosomal location of the human ail gene was confirmed using human/mouse somatic-cell hybrid lines containing portions of human chromosome 7. Because the ail gene mapped near the cystic fibrosis locus and because an abnormal G protein might be ex-pected to contribute to the pathophysiology of this disease, the aoi gene was mapped with respect to the cystic fibrosis locus as defined by the Met oncogene and anonymous DNA marker pJ3.11. The location of the a1i gene proved to be distinct from that of the cystic fibrosis locus.
SPONTANEOUS CHROMOSOME BREAKAGE AND ATYPICAL CHROMOSOME MOVEMENT IN AIEIOSIS OF THE HYBRID BROMUS MARGINATUS

PONTANEOUS chromosome breakage, apparently identical with that S produced by irradiation, has recently been reported in meiosis of an interspecific hybrid, Browms Trinii x R . iiiaritimzrs ( WALTERS 1950). The present hybrid, Brontz~s nzarginatus x R. pseitdolaevipes, also exhibits f ragments at meiosis which indicate the occurrence of chromosome breakage in this division. However, the fragments observed in this hybrid indicate a type of breakage different from that reported previously. h i analysis of this type of chromosome breakage was one ohjective of the present investigation. Metaphase bivalents with thin regions between centromeres and the chiasma are found in the present hybrid and in some other hybrids of Bromus, in whose parent species the bivalent chromosomes are relatively constant in diameter. A second objective of this investigation was the description of the bivalents exhibiting various thin regions, and a discussion of their origin. Chromosome movement in meiotic anaphase by means of terminal secondary centromeric activity has heen described in Zea ( RHOADES and VILKOMERSON 1942) and Secale ( ~ T E R C R E N and PRAKKEN 1746). The present hybrid, in which certain chromatid ends appear to be drawn towards the poles at anaphase, may represent a third example of chromosome movement by means of centromeric activity of terminal regions. A description and discussion of the chromosomes exhibiting this aherrant movement was the final ohjective of the present study.
Expression of BcI-2 Protein and Fas Antigen in Non-Hodgkin's Lymphomas

Expression of Bcl-2 protein and Fas antigens was analyzed in 12 cases offoUicular lymphoma and 32 cases ofdiffuse lymphoma, including 22 B-ceU and 10 T-ceU lymphomas. It was shown that 75% offollicular lymphomas had clear expression of both Bcl-2 protein and Fas antigenm Thus, foUicu-lar lymphomas may have a growth advantage due to their high expression of Bcl-2 protein, which tended to impede apoptosis mediated by Fas antigenL On the other hand, diffuse lymphomas showed various patterns; 28% were double positive, 16% were only Bcl-2 protein-positive, 28% were only Fas antigen-positive, and 28% were double negative or equivocaL Cytocidal assay of seven leukemia/lymphoma cell lines using anti-human Fas monoclonal antibody revealed that overexpression of Bcl-2 protein tended to impede apoptosis mediated by Fas antigen. How-ever, this inhibitory effect of Bcl-2 protein was incomplete and its effect might be dependent upon ceU type. (Am JPathol 1994, 145:330-337)
Resistance to rotavirus infection in adult volunteers challenged with a virulent G1P1A[8] virus correlated with serum IgG antibodies to homotypic VP7 and VP4

Background— Previously, 18 adult volunteers were orally challenged with the virulent human rotavirus strain D (G1P1A[8],NSP4[B]) (Kapikian, et al., 1983. J. Infect. Dis. 147:95). To identify correlates of resistance to rotavirus infection, we analyzed serum IgA and IgG antibody levels to various rotaviral antigens in 16 of the 18 volunteers. Methods— We used immunocytochemistry assays involving a total of 16 different recombinant baculoviruses with each expressing one of the following major serotype/genotype rotavirus proteins for the serologic assays: (i) VP4 with P1A[8]; P1B[4]; P2A[6]; P3[9]; or P4[10] specificity; (ii) VP7 with G1-4, or G9 specificity; and (iii) NSP4 with genotype A, B, C, or D specificity. Results— The prechallenge IgG antibody titers to VP7 types G1,
Sistema de triaje de Manchester: organigramas principales, discriminadores y resultados de la atención de una emergencia pediátrica

Objetivo: identificar a utilizacao das redes sociais na educacao em enfermagem. Metodo: revisao integrativa da literatura nas bases de dados: LILACS, IBECS, Cochrane, BDENF, SciELO, CINAHL, Scopus, PubMed, Portal de Periodicos CAPES e Web of Science, utilizando-se os descritores: social networking e nursing education e as palavras chaves: social networking sites e nursing education, realizada em abril de 2015. Resultados: dos 489 artigos encontrados somente 14 atenderam os criterios de inclusao e exclusao. A maioria dos estudos foi publicada a partir de 2013 (57%), oriunda dos Estados Unidos e do Reino Unido (77,8%). Observou-se a utilizacao das redes sociais com os alunos de enfermagem, de pos-graduacao, mentores e enfermeiros, em cursos de graduacao, educacao hibrida (blended-learning) e na educacao interprofissional. As redes sociais utilizadas no processo de ensino e aprendizagem foram o Facebook (42,8%), Ning (28,5%), Twitter (21,4%) e MySpace (7,1%), por meio de audios, videos, quizzes, animacoes, foruns, orientacoes, apoio, discussoes e em grupo de pesquisa. Conclusao: foram encontradas poucas experiencias utilizando as redes sociais na educacao em enfermagem, sendo que as contribuicoes evidenciam os varios beneficios e as dificuldades encontradas, tornando-se subsidios para o aprimoramento e reavaliacao de sua utilizacao no processo de ensino e aprendizagem.
Test Your Knowledge A MAN WITH AN ACUTE ABDOMEN

ANSWER: 1. The erect chest radiograph of the patient shows “free air under diaphragm”. (Figure 3) 2. Perforated gut. With the history of long-term NSAIDs usage, the most likely diagnosis is perforated peptic ulcer. In a local published studies, the most common site of gastrointestinal perforation was at the stomach (45.7%), followed by duodenum (18.5%), oesophagus (9.9%), small intestine (9.9%), and large intestine (16.0%). 1 Free air in the peritoneum cavity also occurs in the following condition (not for this patient): • Penetrating abdominal injury • Recent abdominal laparotomy/laparoscopy • After peritoneal dialysis • Ruptured pneumatosis intestinal cysts
High-entropy-alloy nanoparticles with 21 ultra-mixed elements for efficient photothermal conversion

Abstract Multi-metallic nanoparticles have been proven to be an efficient photothermal conversion material, for which the optical absorption can be broadened through the interband transitions (IBTs), but it remains a challenge due to the strong immiscibility among the repelling combinations. Here, assisted by an extremely high evaporation temperature, ultra-fast cooling and vapor-pressure strategy, the arc-discharged plasma method was employed to synthesize ultra-mixed multi-metallic nanoparticles composed of 21 elements (FeCoNiCrYTiVCuAlNbMoTaWZnCdPbBiAgInMnSn), in which the strongly repelling combinations were uniformly distributed. Due to the reinforced lattice distortion effect and excellent IBTs, the nanoparticles can realize an average absorption of >92% in the entire solar spectrum (250 to 2500 nm). In particular, the 21-element nanoparticles achieve a considerably high solar steam efficiency of nearly 99% under one solar irradiation, with a water evaporation rate of 2.42 kg m–2 h–1, demonstrating a highly efficient photothermal conversion performance. The present approach creates a new strategy for uniformly mixing multi-metallic elements for exploring their unknown properties and various applications.
WNT11 expression is induced by ERR α and β -catenin and acts in an autocrine manner to increase cancer cell migration

Elevated expression of the orphan nuclear receptor estrogen-related receptor alpha (ERR α ) has been associated with a negative outcome in several cancers, although the mechanism(s) by which this receptor influences the pathophysiology of this disease and how its activity is regulated remains unknown. Using a chemical biology approach it was determined that compounds, previously shown to inhibit canonical Wnt signaling, also inhibited the transcriptional activity of ERR α . The significance of this association was revealed in a series of biochemical and genetic experiments that demonstrate that (a) ERR α , β -catenin ( β -cat) and Lymphoid enhancer-binding factor-1 (LEF-1) form macromolecular complexes in cells, (b) ERR α transcriptional activity is enhanced by β cat expression and vice versa , and (c) there is a high level of overlap among genes previously shown to be regulated by ERR α or β -cat. Furthermore, silencing of ERR α and β -cat expression individually or together dramatically reduced the migratory capacity of both breast and prostate cancer cells in vitro . This increased migration could be attributed to the ERR α / β -cat dependent induction of WNT11. Specifically, using (a) conditioned media from cells overexpressing recombinant WNT11 or (b) WNT11 neutralizing antibodies, we were able to demonstrate that this protein was the key mediator of the promigratory activities of ERR α / β -cat. Together, these data provide evidence for an autocrine regulatory loop involving transcriptional upregulation of WNT11 by ERR α and β -cat that influences the migratory capacity of cancer cells.
QUANTITATIVE EVALUATION OF A STABILIZED PLATFORM SHIPBOARD GRAVITY METER

A new LaCoste and Romberg surface-ship gravity meter mounted on a stabilized platform was tested over the known gravity field of the San Luis Pass salt dome, about twenty miles southeast of Freeport, Texas. A 100 ft boat was used in sea conditions considered average for the shallow offshore areas, waves running from 2 to 6 ft high. An average repeatability of 0.7 mgal was determined for 18 line intersections, of which 14 had differences 1.0 mgal or less. A line by line comparison with the known gravity field indicates an average difference between the known field and the surface meter results of 0.5 mgal. Systematic errors of less than 1.0 mgal were recognized. The platform meter was tested simultaneously with a LaCoste and Romberg gimbal-supported meter, which proved to be more sensitive to the course direction of the boat and could not make adequate horizontal acceleration corrections in rough seas about 15–20 percent of the total time. The meter on the stabilized platform operated at all times in all six directions.
PREVALENCE OF DEPRESSION IN EPILEPSY

Patients with epilepsy are more likely to suffer from psychiatric illnesses, and more specifically depressive disorders (9% to 22%), than the general population. Depression in epilepsy is often described by the temporal correlation to a seizure, with interictal depression being the most commonly described. Furthermore, epileptic patients with depression often report a poorer quality of life on global assessments and are at an increased risk of suicide as compared to the general population, 11.5 percent versus 1.2 percent, respectively. Despite the clinical significance of depression, it often goes unrecognized and hence untreated in this population. Recently, more efforts at screening epilepsy patients for coexisting depression have been undertaken, yielding fair results. However, some epilepsy patients express a certain constellation of symptoms, including an explosive or irritable mood, somatic pains, anxiety and fear, and periods of brief euphoria, which are not captured by common depression screening tools. Fears of antidepressants lowering seizure thresholds coupled with potential pharmacokinetic interactions between antiepileptic and antidepressant medications have strongly contributed to the undertreatment of this population. Finally, the treatment of depressive disorders in epilepsy is understudied and the few existing research studies have yet to display an effective treatment. Depressive disorders in patients with epilepsy pose significant and specific problems with regard to recognition, diagnosis, and treatment that require careful and thorough management.
THE FLOV,lING CHARACTERISTICS OF BLOOD

T HE distribution of blood to the capillary beds depends largely upon two influences, the neuro-muscular mechanisms regulating the caliber of the ar~er­ ioles and smaller vessels, and the flowmg characteristics of blood. (Neuro-muscular control will not be discussed here.) It is apparent that blood flowin~ fr? m an arteriole into a capillary arborIzatlOn has numerous alternative pathways. Because it is impossible for all these alternative channels to be identical in diameter, length and directness, some provision must be at hand to make blood flow through roundabout pas~ages just as readily as through more dIrect ones. If the neuro-muscular mechanisms are excluded the provision must lie in the struct~re of the capillary openings, or in the flowing characteristics of b}ood, or both, since friction within the capIllary tubes would favor flow through the shorter and wider passages. The influence operating at the capillary mouths must be powerful enough to outweigh t~e differences in friction among the capIllaries. These considerations apply regardless of how many capillaries are flowing at one time, because ~ver.t a few will differ among themselves m SIze and shape. Anatomically, two general kinds of capillaries are to be found, (a) the arterio-venous capillaries, which arise as the end-vessels of the arterial side and lead directly to the venules, and (b) the true capillaries, which spring fr~m the walls of the arterioles. The arteno-venous capillaries are generally open and flowing but the true capillaries are open and clo;ed by turns (Zweifach, ~). ~re­ sumably the influence under dISC~ssI.on determines how blood shall be dIstnbuted among the true capillaries arising
Pathogenic Bacterial Proteins and their Anti-Inflammatory Effects in the Eukaryotic Host

Bacteria use multiple strategies to bypass the inflammatory responses in order to survive in the host cells. In this review, we discuss the mechanism of the bacerial proteins in inhibiting inflammation. We highlight the anti-inflammatory roles of the type three secretion proteins including Salmonella AvrA, Enteropathogenic Escherichia coli Cif, and Yersinia YopJ, Staphylococcus aureus extracellular adherence protein, and Chlamydia proteins. We also discuss the research progress on the structures of these anti-inflammatory bacterial proteins. The current therapeutic methods for diseases, such as inflammatory bowel diseases, sclerosis, lack influence on the course of chronic inflammation and infection. Therefore, based on the molecular mechanism of the anti-inflammatory bacterial proteins and their 3-Dimension structure, we can design new peptides or non-peptidic molecules that serve as anti-inflammatory drugs without the possible side effect of promoting bacterial infection. colitis in the of colitis experimental and
Early‐onset dementia

younger than 65 years (n =150) 2. RozanskiA. Blumenthal J, Kaplan J. Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation 1999: 99: 21922217. 3. HemingwayH, MarmotM. Evidencebased cardiology: psychosocial factors in the aetiology and prognosisof coronary heart disease. Systematic review of prospective cohort studies. BMJ 1999: 318(7196): 1460-1467. 4. Linden W, StosselC. MauriceJ. Psychosocial interventions for patients with coronary artery disease: a meta-analysis. Arch Intern Med 1996; 156(7): 745-752. 5. Jones D, West R. Psychological rehabilitationafter myocardial infarction: multicentre randomised controlled trial. BMJ 1996: 313(7071): 1517-1521. D Diagnostic category
Role of genetic disorders in acute recurrent pancreatitis

There was remarkable progress in the understanding of the role genetic risk factors in chronic pancreatitis. These factors seem to be much more important than thought in the past. The rare autosomal-dominant mutations N29I and R122H of PRSS1 (cationic trypsinogen) as well as the variant N34S of SPINK1 (pancreatic secretory trypsin inhibitor) are associated to a disease onset in childhood or youth. Compared to chronic alcoholic pancreatitis the progression is slow so that for a long time only signs of acute-recurrent pancreatitis are found. Only at later time points (more than 10-15 years) there is evidence for chronic pancreatitis in the majority of patients. Acute recurrent pancreatitis may therefore be regarded as a transition state until definite signs of chronic pancreatitis are detectable.