Miracle-dz/UniFAR-FTUs huggingface dataset:
ALTERATIONS OF MUSCLE FATIGABILITY AND EXERCISE CAPACITY AFTER MAXIMAL EXERCISE IN YOUNG ADULTS WITH CYSTIC FIBROSIS

Background: Cystic fibrosis is a genetic disorder affecting many physiological systems that may cause alterations of skeletal muscle strength, such as lowering of exercise capacity and impairment of physical activity. Objectives: The aim of this study was to investigate the effects of maximal exercise training on exercise capacity and muscle fatigability in cystic fibrosis young adults with moderate respiratory disease. Methods: Twenty eight young adults (18 ♂ and 10 ♀) were enrolled in the study. The study included two groups of young adults; the group of CF comprised of fourteen young adults with cystic fibrosis (9 ♂ and 5 ♀) and the group of healthy subjects comprised of fourteen age-matched healthy subjects (9 ♂ and 5 ♀). All participants have performed a maximal exercise test, muscle fatigue assessment, and cross-section area imaging. All measures were recorded and analyzed. Results: This study outcome demonstrated that there were lower FEV1, FVC, exercise capacity and had more oxygen desaturation with more breathing reserve index in young adults with CF than healthy subjects with p<0.05. Whereas, the two groups of this study had nonsignificant differences in cross section area, muscle fatigability, and maximal contraction of the quadriceps muscle with p>0.05. Conclusions: This study suggests that young adults with cystic fibrosis who had moderate pulmonary disorder and healthy subjects have similar effects in cross section area, muscle fatigability, and maximal contraction of the quadriceps muscle. Whereas maximal exercise has negative effects on exercise capacity in young adults with CF.
Progenitor and embryonic stem cell transplantation for myocardial angiogenesis and functional restoration

The discovery of the main risk factors, the development of potent new drugs and sophisticated procedures and interventions, have not yielded the expected ‘victory’ over coronary heart disease. In fact, as the number of heart attacks decreases, the number of patients with refractory myocardial ischaemia and congestive heart failure is rapidly on the rise. Hence, novel therapeutic approaches are urgently required. The concept of regenerative medicine using the body's own stem cells and growth factors to repair tissues is gradually coming closer to reality. Work regarding stem cells is ever increasing and is paving the way for medical repairs, including mending a damaged heart. This review aims to track recent developments in myocardial cell transplantation techniques. What are stem cells? Terminology nomenclature
An Experiment on Semantic Emotional Evaluation of Chats

—Electronic conversations always contain an emotional charge. Being able to evaluate such emotional charge is an interesting challenge, and valuable conclusions can be obtained if that process is performed automatically. In this paper, we present a Semantic Emotional Evaluator for Chats, named Chat-SEE, that has been used for evaluating the emotions in a chat conversation. The results obtained are quite promising.
Stimulation strategies for neurons and fibres Connecting biological and artificial neural networks

Electrical stimulation of nerve tissue and recording of neural electrical activity are the basis of emerging prostheses and treatments for many neurological disorders. Here we present an attempt to connect an in vitro Biological Neuronal Network (BNN) with an Artificial Neural Network (ANN) implemented in a neuromorphic board. This work can be seen as the first step towards the realization of an innovative brain-prostheses.
A phylogenetic analysis of Myriapoda (Arthropoda) using two nuclear protein-encoding genes

Nucleotide and inferred amino acid sequences from two nuclear protein-encoding genes, elongation factor- l a and RNA polymerase 11, were obtained from 34 myriapods and 14 other arthropods to determine phylogenetic relationships among and within the myriapod classes. Phylogenetic analyses using maximum parsimony and maximum likelihood methods recovered all three represented myriapod classes (Chilopoda, Diplopoda, Symphyla) and all multiply sampled chilopod and diplopod orders, often with high node support. In contrast, relationships between classes and between orders were recovered less consistently and node support was typically lower. The temporal structure of phylogenetic diversification in Myriapoda may explain this apparent pattern of the phylogenetic recovery.
An Exploration of Constructive Approach to the Higher Institutions’ MOOC with Chinese Local Characteristics

Although the paradigm change led by MOOC in the field of higher education has many supporters, and MOOC has been applied widely for many years in the world. Now, more and more people begin to pay attention to the disputes about disadvantages and advantages of the MOOC. At first, the article indicates that some innate bad genes of MOOC, such as the cultural erosion tendency, the high drop out rate, the low effectiveness of the teaching evaluation and the low reliability of the course credits. And then the article faces the process of Chinese MOOC construction in different colleges and universities, and focuses on how to improve the innate bad genes of MOOC. Finally, the article gives some suggestions to explore a constructive approach to the higher institutions’ MOOC with Chinese local characteristics.
Texture Analysis Based on Pi-Rads 4/5-Scored MRI Images Combined with Machine Learning to Distinguish Benign Lesions from Prostate Cancer

Background: To extract the texture features of ﻿Apparent Diffusion Coefficient (ADC) images in Mp-MRI and build a machine learning model based on radiomics texture analysis to determine its ability to distinguish benign from prostate cancer (PCa) lesions using PI-RADS 4/5 score.Materials and methods: First, use ImageJ software to obtain texture feature parameters based on ADC images; use R language to standardize texture feature parameters, and use Lasso regression to reduce the dimensionality of multiple feature parameters; then, use the feature parameters after dimensionality reduction to construct image-based groups. Learn R-Logistic, R-SVM, R-AdaBoost to identify the machine learning classification model of prostate benign and malignant nodules. Secondly, the clinical indicators of the patients were statistically analyzed, and the three clinical indicators with the largest AUC values were selected to establish a classification model based on clinical indicators of benign and malignant prostate nodules. Finally, compare the performance of the model based on radiomics texture features and clinical indicators to identify benign and malignant prostate nodules in PI-RADS 4/5.Results: The experimental results show that the AUC of the R-Logistic model test set is 0.838, which is higher than the R-SVM and R-AdaBoost classification models. At this time, the corresponding R-Logistic classification model formula is: Y_radiomics=9.396-7.464*median ADC-0.584 *kurtosis+0.627*skewness+0.576*MRI lesions volume; analysis of clinical indicators shows that the 3 indicators with the highest discrimination efficiency are PSA, Fib, LDL-C, and the corresponding C-Logistic classification model formula is: Y_clinical =-2.608 +0.324*PSA-3.045*Fib+4.147*LDL-C, the AUC value of the model training set is 0.860, which is smaller than the training set R-Logistic classification model AUC value of 0.936. Conclusion: The machine learning classifier model is established based on the texture features of radiomics. It has a good classification performance in identifying benign and malignant nodules of the prostate in PI-RADS 4/5. This has certain potential and clinical value for patients with prostate cancer to adopt different treatment methods and prognosis.
Online identification applied on a nonlinear semi-batch process

 Abstract — This paper describes the simulations of an exothermic semi batch process control. All simulations are based on a mathematical model of a real process, which runs in a semi batch reactor. The process is strongly exothermic and the temperature inside the reactor is mainly affected by the feeding speed of the chemical compound causing the reaction. Nonlinear system control is generally difficult, so it is also in this case. To tune the controller an online identification was applied. Studied were two methods, the recursive least square identification method and the same method enhanced by exponential forgetting. The mathematical simulations were performed to find an appropriate control method. Several different methods were compared to achieve the best feeding profile.
Interaction of Radioactive Substances, Salts and Microorganisms in Paddy Soils in Dodoma, Tanzania

Microorganism tolerance to high radioactivity and salinity was discovered in the soils deposited from the weathered granite in Bahi Swamp of Dodoma Region, Tanzania, which has an area of 125 – 140 km 2 and located approximately 50 km to the west of Dodoma. This swamp is underlain by layers of black clayey soils about 110 m thick. Some of the clay layers have been found to be radioactive due to their content of uranium-bearing minerals such as uranyl vanadates; (Ba, Pb)(UO 2 ) 2 V 2 O 8 ･ 5(H 2 O). The β ( γ )-ray counts and trace elements were analyzed respectively by a scintillation counter and X-ray fluorescence (XRF) spectrometer. Salt and black clayey soils showed their γ -ray radioactivity ranging from 130 to 200 cpm and contained Sr abundant, and Ga, Rb, Y, and Zr slightly less abundant, whereas La, Ce, Th and Ni detected slightly. Besides, their mineralogical characteristics were analyzed by using X-ray powder diffractometer (XRD), which identified clay minerals such as smectite, mica clay minerals and kaolin minerals whereas halite and bischofite in salts. The presence of microorganisms was observed with Scanning Electron Microscopy (SEM) equipped with Energy Dispersive X-ray Analyzer (EDS), and Transmission Electron Microscopy (TEM). Filamentous bacteria were fully covered with flakes of clay minerals, which are recognized as kaolinite from its hexagonal particles. The clay minerals such as kaolinite, smectite, etc. could have functions to alleviate or even absorb the effect of the salinity and the radiation. This is the first report revealing high radioactivity of paddy soils and salt associated with microorganisms in Dodoma, Tanzania.
The Cation-dependent Mannose 6-Phosphate Receptor STRUCTURAL REQUIREMENTS FOR MANNOSE 6-PHOSPHATE BINDING AND OLIGOMERIZATION*

The structural requirements for oligomerization and the generation of a functional mannose 6-phosphate (Man-6-P) binding site of the cation-dependent mannose 6-phosphate receptor (CD-MPR) were analyzed. Chemical cross-linking studies on affinity-purified CD-MPR and on solubilized membranes containing the receptor indicate that the CD-MPR exists as a homodimer. To determine whether dimer formation is necessary for the generation of a Man-6-P binding site, a cDNA coding for a truncated receptor consisting of only the signal sequence and the extracytoplasmic domain was constructed and expressed in Xenopus laevis oocytes. The expressed protein was completely soluble, monomeric in structure, and capable of binding phosphomannosyl residues. Like the dimeric native receptor, the truncated receptor can release its ligand at low pH. Ligand blot analysis using bovine testes 6-galac-tosidase showed that the monomeric form of the CD-MPR from bovine liver and testes is capable of binding Man-6-P. These results indicate that the extracytoplasmic domain of the receptor contains all the information necessary for ligand binding as well as for acid-dependent ligand dissociation and that oligomerization is not required for the formation of a functional Man-6-P binding site.
Hardware and Software Implementation of Decentralized Active Demand Response (DADR) System Supporting Primary Regulation

The concept of demand response (DR) is relatively well-known. There is an extensive literature on possible DR system services and evaluation of regulative potential, based on statistical analyses of data concerning loads suitable for provision of the service. Some of the presented concepts have been implemented in real applications. However, as far as the authors know, this paper presents the first attempt at an implementation of a decentralized active DR system (DADR), without communication between devices, in the form of a laboratory setup consisting 1000 devices enabling primary regulation support. The proposed implementation covers an original hardware design, a software platform for flexible system development, a laboratory arrangement enabling an objective assessment of the quality of service provided by the DADR system, as well as results of a pilot test in real power system. The practical realization of the DADR system is based on an earlier elaborated and theoretically investigated control algorithm, presented in previous papers.
Establishment of the Standardized Uptake Values of 99mTc-MDP in Normal Vertebrae for SPECT/CT Quantification

Purpose To establish the standardized uptake value (SUV) of Tc-99m-methylene diphosphonate (MDP) for normal vertebra in both Chinese male and female by using a SPECT/CT scanner. Methods A retrospective study was carried out involving 116 men and 105 women who underwent SPECT/CT scan using 99m Tc-MDP. We acquired the SUV, CT value of 2416 normal vertebra in total and analyzed the difference of SUV between men and women. We analyzed the vertebra data with no significant difference of SUVmax in male and female group. The correlations between SUVmax value and CT value, age, height, weight in each group were also analyzed. Results The SUVmax, SUVmean of vertebra in men were markedly higher than those in women( P < 0.0009). Specifically, for males, the SUVmax of C1, C2-4 and C5-L5 vertebra appeared to have significant differences( P < 0.05), while no significant difference of the SUVmax of C1-L5 vertebra were observed in females( P < 0.05). The SUVmax of each vertebral segment showed a strong negative correlation with CT values in both men and women(r=-0.89,-0.92; P < 0.0009). The SUVmax of vertebra showed weak significant correlation with weight and height in male (r = 0.4, P < 0.0009;r = 0.28, P = 0.005),and weak significant correlation with weight in females(r = 0.32,P = 0.009). study initially SUVmax, SUVavgmean of normal vertebra in both Chinese men and women with a large sample population,and summarized the SUVmax of vertebra with no significant difference. The results could provide quantitative reference for and the evaluation of response in vertebral lesions.
CMAR_A_257685 6999..7008

*These authors contributed equally to this work Background: Studies focused on surgical interventions of spinal metastases of nasopharyngeal carcinoma (SMNPC) are blank. Methods: Patients with SMNPC who received surgical treatment in our center between 2005 and 2017 were included. Univariate and multivariate analysis of various clinical characteristics and operation-related data were analyzed to identify the independent factors that affected prognosis. Factors with P values of 0.1 or less were subjected to multivariate Cox regression analysis. P values of 0.05 or less were considered statistically significant. Results: A total of 30 patients with SMNPC treated with surgery were included. The thoracic spine was the most frequently involved site. The patients in this series achieved good overall survival (OS, 20.26 months) with limited perioperative complications. The univariate analysis suggested that preoperative Karnofsky performance scale, number of spinal metastases, number of visceral metastases, preoperative Frankel score, surgical resection mode and Ki 67 were potential prognostic factors. In the multivariate analyses, number of visceral metastases, preoperative Frankel score and resection mode were found to be independent prognostic factors. Conclusion: This is the first study focusing on surgical outcomes in SMNPC. The thoracic spine was the most frequently involved site of SMNPC. Preoperative Frankel score, number of visceral metastasis and surgical resection mode were independent prognostic factors for SMNPC. Combined with adjuvant therapies, surgical interventions should be recommended early when necessary.
rehabilita-Dual-energy X-ray absorptiometry in the clinical evaluation of body composition and bone mineral density in patients with chronic obstructive pulmonary disease 1–3

Background: Depletion of fat-free mass (FFM) occurs in a con-siderable number of patients with chronic obstructive pulmonary disease (COPD). Objective: The goal of the study was to determine whether dual-energy X-ray absorptiometry (DXA) is an applicable method in the clinical evaluation of body composition in COPD. Design: In a cross-sectional study in 79 COPD patients participating in a pulmonary inpatient program and in 23 healthy volunteers, DXA was compared with deuterium dilution (Deu) in the estimation of FFM. Bone mineral density (BMD), a DXA measurement, was also compared between the 2 groups. Results: FFM DXA was highly related to FFM Deu in men ( R 2 = 0.93, P < 0.001) and women ( R 2 = 0.91, P < 0.001). On average, DXA resulted in higher FFM values than did Deu in COPD patients (3.4 kg; P < 0.001) and in healthy volunteers (2.1 kg; P < 0.001). Furthermore, the intramethod difference in FFM was higher in men than in women in the COPD group ( P < 0.05) and in healthy volunteers ( P < 0.001). BMD was lower in the COPD group than in the healthy, age-matched volunteers ( P < 0.001). In 56% of the COPD patients, there were indications of bone mineral loss, defined as a BMD <1 SD of a matched reference population provided by the software. BMD was <2 SDs in 36% of the COPD patients. Conclusions: DXA appears to be a suitable alternative method to Deu for assessing body composition and is also of value in identifying bone mineral loss in COPD patients, and is therefore applicable in the clinical evaluation of these patients.
Recurrent Selection for Yield in Soybeans 1 * 2

Procedures have been developed for yield testing of soybeans (Glycine max (L.) Merr. ) that permit Si testing with 1 year per cycle and S 4 testing with 2 years per cycle. The principal factors in the program include efficient procedures for obtaining crossed seed by hand pollination, crossing and generation advance in Puerto Rico, and yield tests in Iowa by use of hill plots. Details for each of the three factors are discussed. With the facilities available, expected genetic gain per year for yield was calculated for Si testing without male sterility (Si), S x testing with male sterility Si( 8T ), S 4 testing without male sterility (S4), and half-sib family selection with male sterility (HF). The greatest expected gain per year was obtained with Si testing. There is more genetic variability among S 4 lines than among Si lines due to inbreeding, but expected genetic gain is less for S 4 testing because 2 years are required per cycle. SKSD had less ex pected gain per year than Si or S 4 testing because 2 years are required per cycle if homozygous male-fertile genotypes are evaluated. Expected genetic gain was least for HF because less genetic variability is expressed among lines than for the other three methods.
Elsevier Editorial System(tm) for Drug and Alcohol Dependence Manuscript Draft Manuscript Number: AL-17-0216R2 Title: Impulsivity related personality traits and cigarette smoking in adults: a meta-analysis using the UPPS-P model of impulsivity and reward

Background: Although there is considerable evidence of an association between impulsivity and cigarette smoking, the magnitude of this association varies across studies. Impulsivity comprises several discrete traits which may influence cigarette use in different ways. The present meta-analysis aims to examine the direction and magnitude of relationships between specific impulsivity-related traits, namely lack of premeditation, lack of perseverance, sensation seeking, negative urgency, positive urgency and reward sensitivity and both smoking status and severity of nicotine dependence in adults across studies and to delineate differences in effects across these relationships. Methods: Ninety-seven studies were meta-analysed using random-effects models to examine the relationship between impulsivity-related traits and smoking status and severity of nicotine dependence. A number of demographic and methodological variables were also assessed as potential moderators. Results: Smoking status and severity of nicotine dependence were significantly associated with all impulsivity-related traits except reward sensitivity. Lack of premeditation and positive urgency showed the largest associations with smoking status (r=0.20, r=0.24 respectively), while positive urgency showed the largest association with severity of nicotine dependence (r=0.23). Study design moderated associations between lack of premeditation and lack of perseverance and smoking status, with larger effects found in cross-sectional compared to prospective studies. Conclusions: Findings suggest that impulsivity is associated with an increased likelihood of being a smoker and greater nicotine dependence. Specific impulsivity-related traits differentially relate to smoking status and severity of nicotine dependence. Understanding the complexity of impulsivity-related traits in relation to smoking can help to identify potential smokers and could inform cessation treatment.
Non-stationary Contextual Pricing with Safety Constraints

In a contextual pricing problem, a seller aims at maximizing the revenue over a sequence of sales sessions (described by feature vectors) using binary-censored feedback of “sold” or “not sold”. Existing methods often overlook two practical challenges (1) the best pricing strategy could change over time; (2) the prices and pricing policies must conform to hard constraints due to safety, ethical or legal restrictions. We address both challenges by solving a more general problem of universal dynamic regret minimization in proper online learning with exp-concave losses — an open problem posed by Baby & Wang (2021) that we partially resolve in this paper. Here “dynamic regret” measures the performance relative to a non-stationary sequence of policies, and “proper” means that the learner must choose feasible strategies within a pre-defined convex set, which we use to model the safety constraints. In the case of a known log-concave market noise, our algorithm achieves ˜ O ( d 3 T 1 / 3 C 2 / 3 T ∨ d 3 ) dynamic regret that is optimal w.r. t. T and C T , adapts to unknown non-stationarity C T and remains feasible throughout. We also report other results under weaker assumptions. To the best of our knowledge, we are the first to obtain provable guarantees in non-stationary contextual pricing.