Miracle-dz/UniFAR-FTUs huggingface dataset:
Studies of Potency and Efficacy of an Optimized Artemisinin-Quinoline Hybrid against Multiple Stages of the Plasmodium Life Cycle

A recently developed artemisinin-quinoline hybrid, named 163A, has been shown to display potent activity against the asexual blood stage of Plasmodium, the malaria parasite. In this study, we determined its in vitro cytotoxicity to mammalian cells, its potency to suppress P. berghei hepatic infection and to decrease the viability of P. falciparum gametocytes, in addition to determining whether the drug exhibits efficacy of a P. berghei infection in mice. This hybrid compound has a low level of cytotoxicity to mammalian cells and, conversely, a high level of selectivity. It is potent in the prevention of hepatic stage development as well as in killing gametocytes, denoting a potential blockage of malaria transmission. The hybrid presents a potent inhibitory activity for beta-hematin crystal formation, in which subsequent assays revealed that its endoperoxide component undergoes bioactivation by reductive reaction with ferrous heme towards the formation of heme-drug adducts; in parallel, the 7-chloroquinoline component has binding affinity for ferric hemin. Both structural components of the hybrid co-operate to enhance the inhibition of beta-hematin, and this bitopic ligand property is essential for arresting the growth of asexual blood parasites. We demonstrated the in vivo efficacy of the hybrid as an erythrocytic schizonticide agent in comparison to a chloroquine/artemisinin combination therapy. Collectively, the findings suggest that the bitopic property of the hybrid is highly operative on heme detoxification suppression, and this provides compelling evidence for explaining the action of the hybrid on the asexual blood stage. For sporozoite and gametocyte stages, the hybrid conserves the potency typically observed for endoperoxide drugs, and this is possibly achieved due to the redox chemistry of endoperoxide components with ferrous heme.
Soil Erosion and Soil Organic Carbon in the Forest-Steppe Zone: A Case Study in Baga Mukhar, West Khentei, Mongolia

Specifics and relationships between soil erosion and soil organic carbon in the Mongolian forest-steppe were studied in this research, in a case of Baga Mukhar catchment, west Khentei. Soil erosion was estimated by the Cesium-137 isotope tracing method. For estimation of soil redistribution rates from inventories of 137Cs, diffusion migration model used in grazing lands and mass balance model-2 used in cultivated land. In total, 38 soil samples were taken from 5 isosectors. The mean soil redistribution of the catchment was -3.67 t ha y. In cultivated land, soil erosion was the highest with a value of -15.47 t ha y and it gets higher (-24.43 t ha y) if we take into account that the cultivated land is located at the bottom of the valley where has deposition. Soil erosion in the south-facing slopes is 5.1 times higher than north-facing slopes, which shows slope differences significantly influence vegetation growth and soil erosion. The average soil organic carbon of the study area is 4.37 %. SOC was highest in the forest area (7.33 %) and the lowest in the agriculture field (2.48 %). SOC in the north facing slope was 2.4 times higher than the south facing slope. Isosectors mean value of soil redistribution and SOC is comparatively well corresponded (r=0.567). Soil erosion and soil organic loss in agriculture is a significant, it needs more appropriate management practice and soil conservation activities in the Mongolian forest-steppe.
The Effects of Consumers’ Buying Behavior on E-Commerce Pricing in the Highly Developed Emerging Market: The Case of Singapore

This paper is focused on Singapore and its e-commerce markets. It contains the theoretical part and the conduct of an empirical study where the results are studied. This study is further extended as an investigation of the effects of consumers’ buying behavior on the e-commerce market in the case of Singapore, a highly developed emerging market. This research aims to gain a detailed insight and better understand Singaporeans buying behavior and how it may or may not affect the e-commerce market.
Sleep Disorders in Cancer—A Systematic Review

Introduction: Sleep disorders, especially insomnia, are very common in different kinds of cancers, but their prevalence and incidence are not well-known. Disturbed sleep in cancer is caused by different reasons and usually appears as a comorbid disorder to different somatic and psychiatric diagnoses, psychological disturbances and treatment methods. There can be many different predictors for sleep disturbances in these vulnerable groups, such as pre-existing sleep disorders, caused by the mental status in cancer or as side effect of the cancer treatment. Methods: A systematic literature review of 8073 studies was conducted on the topic of sleep and sleep disorders in cancer patients. The articles were identified though PubMed, PsycInfo and Web of Knowledge, and a total number of 89 publications were qualified for analysis. Results: The identified eighty-nine studies were analyzed on the topic of sleep and sleep disorders in cancer, twenty-six studies on sleep and fatigue in cancer and sixty-one studies on the topic of sleep disorders in cancer. The prevalence of sleep disturbences and/or sleep disorders in cancer was up to 95%. Discussion: Sleep disturbances and sleep disorders (such as insomnia, OSAS, narcolepsy and RLS; REM-SBD) in cancer patients can be associated with different conditions. Side effects of cancer treatment and cancer-related psychological dysfunctions can be instigated by sleep disturbances and sleep disorders in these patients, especially insomnia and OSAS are common. An evidence-based treatment is necessary for concomitant mental and/or physical states.
Feature Extraction Approach in Hyperspectral Data

In general, feature extraction deals with the problem of finding the most informative, distinctive, and reduced set of features and improve the success of data processing. The features should contain information required to distinguish between classes, be insensitive to irrelevant variability in the input, and also be limited in number, to permit, efficient computation of the applied functions and to limit the amount of data required. In many cases, it is an important step in the solutions of many tasks aiming to extract the relevant information from the available large datasets. The aim of this study is to apply a feature extraction approach to a hyperspectral image and extract different features from the dataset and reduce its dimensionality into meaningful orthogonal features. The final analysis was performed in a test site situated in central Mongolia using 242 band Hyperion data. Overall, the study indicated that the Hyperion hyperspectral data could be effectively reduced into meaningful features through a feature extraction process.
State-of-Health Estimation for Lithium-Ion Batteries Based on Decoupled Dynamic Characteristic of Constant-Voltage Charging Current

State-of-health (SoH) is one of the critical battery states that must be estimated and closely monitored by the on- board battery management system in electric vehicles (EVs). In this study, the battery SoH, especially the capacity fade, is calculated based on the decoupled characteristic of the charging current under the constant-voltage (CV) scenario. First, a dynamic-decoupled parameter identification method is proposed to extract the parameters of the simplified second-order resistor–inductor (RL) network-based equivalent circuit model (ECM), developed by the authors. Second, the dynamic characteristics of the decoupled CV charging currents at different aging states are qualitatively investigated, and the corresponding time constant is selected as a feature-of-interest (FoI) to reflect the battery capacity degradation. Third, the aging data based on two types of lithium-ion batteries are employed to evaluate the performance of the proposed method. Verification results demonstrate that the proposed parameter identification method yields a reduced computational cost with a satisfactory fitting performance, compared to the conventional methods. The proposed parameterization method and the selected FoI guarantee the root-mean-square errors of the estimated SoH less than 2%, and the comparative results further validate the superiority of the selected FoI in terms of the SoH estimation accuracy.
Bilateral maxillary supplemental incisors - A case report

Supernumerary teeth are odontostomatological anomalies resulting in increased number of teeth in addition to normal dentition. Supernumerary teeth usually associated with syndromes such as Cleidocrainal dysostosis, Gardner’s syndrome, cleft lip and palate, Fabry disease and Rubinstein-Taybi syndrome etc. But sometimes these teeth are present alone without any symptom. In present case patient has permanent maxillary supernumerary teeth almost similar to lateral incisors in addition to normal set of teeth.
Robot Teams: From Diversity to Polymorphism

This is a comprehensive volume on robot teams that will be the standard reference on multi-robot systems. The volume provides not only the essentials of multi-agent robotics theory but also descriptions of exemplary implemented systems demonstrating the key concepts of multi-robot research. Information is presented in a descriptive manner and augmented with detailed mathematical formulations, photos, diagrams, and source code examples.
Chemical Emissions from Cured and Uncured 3D-Printed Ventilator Patient Circuit Medical Parts

Medical shortages during the COVID-19 pandemic saw numerous efforts to 3D print personal protective equipment and treatment supplies. There is, however, little research on the potential biocompatibility of 3D-printed parts using typical polymeric resins as pertaining to volatile organic compounds (VOCs), which have specific relevance for respiratory circuit equipment. Here, we measured VOCs emitted from freshly printed stereolithography (SLA) replacement medical parts using proton transfer reaction mass spectrometry and infrared differential absorption spectroscopy, and particulates using a scanning mobility particle sizer. We observed emission factors for individual VOCs ranging from ∼0.001 to ∼10 ng cm–3 min–1. Emissions were heavily dependent on postprint curing and mildly dependent on the type of SLA resin. Curing reduced the emission of all observed chemicals, and no compounds exceeded the recommended dose of 360 μg/d. VOC emissions steadily decreased for all parts over time, with an average e-folding time scale (time to decrease to 1/e of the starting value) of 2.6 ± 0.9 h.
Living in Patchy Habitats: Substrate Selection for Basking by Sympatric Lizards in Contrasted Anthropogenic Habitats in Western France

The influence of temperature on the physiological processes in reptiles is well known, for example growth, reproduction, muscular energy are all largely temperature dependent and therefore temperature is a key aspect of reptilian ecology. However, there may be constraints on the ability of reptiles to harness thermal energy, particularly during cold seasons in the temperate zones. Substrate selection is a key aspect in thermoregulation and can enhance heat uptake. For example, wood substrates are known to increase rates of heat gain in basking reptiles enabling earlier attainment of optimum body temperatures compared to other substrate types, which enables increased time available for other activities. In this paper we describe substrate use for basking in two species of lizard, Lacerta bilineata and Podarcis muralis in a hedgerow and suburban garden in western France compared against a null model of substrate availability. When different substrates were pooled based on their material similarities both species were recorded in greater frequency on wood based materials in comparison to their availability compared to non-wood substrates. However at a finer level, in comparison to substrate availability (fallen tree branches, tree stumps, open ground etc), P. muralis showed strong substrate selection for basking, whereas L. bilineata did not depart significantly from the null model. We speculated that intra-specific aggression in L. bilineata was a possible cause of this result due to dominant individuals limiting smaller or female lizards from accessing prime basking sites. Differences in communal basking between the two species supported this notion.
Twitter Twitter - but Who Is Listening?: A Review of the Current and Potential Use of Twittering as a Tourism Marketing Tool

This paper investigates the use of twittering as a tourism marketing, tool from the perspectives of destination marketing organisations (DMO), hotels and the consumer. Twittering is a social networking tool and, as with all such tools - especially one that has existed only since 2006 - its use is still evolving. This study had initially two objectives: to review the current use of twitter by DMOs and by hotels, but during the course of the research sufficient information was obtained from both these organisations to add a third objective, the perceived use of twittering by tourists. Using twitter as the survey instrument, in mid 2009 over 400 hotels and DMOs were contacted about their use of twitter as a marketing tool, both now and in the future. The results suggest that because twitter is the new kid on the social networking block and as its development is still evolving, both organisations and consumers are struggling to understand its full potential. Although it remains open as to twitter's effectiveness as marketing tool, two questions still remain - can a organisation be real friend, and the much bigger question - who is actually listening? The paper concludes that twittering provides a voice for the consumer to learn and to share common experiences, and outlines some issues that require further research.
Economic evaluation of disassembly processes in remanufacturing systems

A model to deal with the disassembly processes in remanufacturing systems is presented with focus being on evaluating their economic consequences. More specifically, the model assists decisions such as to which degree and for the sake of which components should the returned items be disassembled. Consequently, using the economic values of recoverable items, the inventory holding costs of these items are obtained. This information is further used to determine the inventory control policy. To access such economic values, the above average cost approach is compared with the net present value method. The latter is often considered a more ‘correct’ way in remanufacturing systems from the viewpoint of inventory control. The results from the economic evaluation model are intended to aid companies in systematically evaluating current as well as projected remanufacturing systems.
Reliability Enhancement of Power IGBTs under Short-Circuit Fault Condition Using Short-Circuit Current Limiting-Based Technique

Like the widely-used semiconductor switch, Insulated Gate Bipolar Transistors (IGBTs) are subject to many failures and degradation in power electronic converters. In Short Circuit Fault (SCF), as the most reported failures in IGBTs, drastic, sudden temperature rise, and peak SCF current are widespread failures owing to a relatively long delay of the protection subsystem. This paper proposes a protection strategy to limit the junction temperature rise by limiting the SCF current by adding a small value resistor in the IGBT emitter. Second, it reduces the SCF current to a value much less than the saturated current. With the proposed control approach, sudden temperature rise during SCF is controlled, preventing significant failure in IGBTs. The extension of the permissible SCF time is achieved even for the cases with temporary arcs. A simple control loop activates in the SCF condition and does not create slow transients for the IGBT. The results of this paper are validated through simulation and experiment.
Jump Rope Training

The world’s best-selling jump rope training guide returns, and it’s bigger, better, and more complete than ever! In Jump Rope Training, Second Edition, former U.S. wrestling champion Buddy Lee presents his jump rope training system used by over 25 U.S. Olympic teams. Workouts for a variety of sport skill and fitness components are included, such as endurance, strength and power, speed, agility, and balance. This second edition also includes the latest on rehabilitation of sport injuries and optimizing body composition for athletic performance. And, to get you started immediately, Jump Rope Training presents sample sport-specific training programs for more than 40 sports. If you’re ready to take your workouts to the next level, turn to the system that the world’s top athletes have come to rely on. Jump Rope Training will not only change the way you train but also change how you feel, look, and perform. It’s the proven approach to improving fitness and performance.
Different Prevalence of Alarm, Dyspeptic and Reflux Symptoms in Patients with Cardia and Non-cardia Gastric Cancer.

BACKGROUND AND AIMS Symptoms of patients with gastric cancer (GC) are often unspecific and differences in symptoms between patients with cardia and non-cardia GC have been poorly investigated. We aimed to characterize symptoms of patients with cardia and non-cardia GC. METHODS Patients with cardia (Siewert type II and III) and non-cardia GC were recruited in the German multicenter cohort of the Gastric Cancer Research (staR) study between 2013 and 2017. Alarm, dyspeptic and reflux symptoms at the time of presentation were documented using a self-administered questionnaire. RESULTS A completed self-administered questionnaire was available for 568/759 recruited patients (132 cardia GC, 436 non-cardia GC, male 61%, mean age 64 years). Dyspeptic symptoms were more common in patients with non-cardia GC (69.0 vs. 54.5%, p=0.0024). Cardia GC patients reported more frequently alarm symptoms (69.7 vs. 44.7%, p<0.0001), and were more likely to have Union for International Cancer Control (UICC) stage III-IV (54.1vs. 38.9%, p=0.0034). Especially, dysphagia and weight loss were more common in patients with cardia GC (49.2 vs. 6.4 %, p<0.0001 and 37.1 vs. 25.7%, p=0.02, respectively). No differences between the two groups were observed with respect to reflux symptoms. Patients with alarm symptoms were more likely to have UICC stage III-IV at presentation (69.4 vs. 42.9%, p<0.0001). CONCLUSIONS In clinical practice the symptom pattern at presentation may serve as a hint for tumor localization. Despite the fact that they are common in the general population, dyspeptic symptoms offer a chance for earlier GC detection. Thus, in patients with dyspeptic symptoms who fail empiric approaches, endoscopy should not be delayed.
Automated insular surface finishing by ball end magnetorheological finishing process

ABSTRACT Ball end magnetorheological finishing (BEMRF) is a process employed for precision finishing of flattened, intricate form complex 3D surfaces up to the nano level. Roughness of a surface determines the quality of results produced, which is usually measured by stylus-based instruments, with some optical methodologies also being adopted. These conventional methods when used for BEMRF tend to introduce errors in the part, which have to be removed from its fixture for measurement, and it is not feasible to remount it in the exactly same orientation again. Applications such as insular finishing (i.e., confined to a narrow region on the workpiece) demand the workpiece to be kept in the same orientation throughout, leading to requirement of measuring roughness in situ during the BEMRF process. A confocal sensor fits the requirement because of its confined design and lightweight capabilities. This work presents integration of a confocal sensor into the BEMRF setup for in situ roughness measurement. An initial Ra value of 352 nm was reduced to 289 nm just by insular finishing before finishing the full surface down to 78 nm in the case of a grinding error, from 420 nm to 342 nm by insular finishing, and finally down to 142 nm in the case of lapping error.
Robust Reconnaissance Asset Planning Under Uncertainty

This thesis considers the tactical reconnaissance asset allocation problem in military operations. Specifically this thesis presents methods to optimize, under uncertain conditions, tactical reconnaissance asset allocation in order to maximize, within acceptable levels of asset risk exposure, the expected total information collection value. We propose a deterministic integer optimization formulation and two robust mixedinteger optimization extensions to address this problem. Robustness is applied to our model using both polyhedral and ellipsoidal uncertainty sets resulting in tractable mixed integer linear and second order cone problems. We show through experimentation that robust optimization leads to overall improvements in solution quality compared to non-robust and typical human generated plans. Additionally we show that by using our robust models, military planners can ensure better solution feasibility compared to non-robust planning methods even if they seriously misjudge their knowledge of the enemy and the battlefield. We also compare the trade-offs of using polyhedral and ellipsoidal uncertainty sets. In our tests our model using ellipsoidal uncertainty sets provided better quality solutions at a cost of longer average solution times to that of the polyhedral uncertainty set model. Lastly we outline a special case of our models that allows us to improve solution time at the cost of some solution quality. Technical Supervisor: Stephan E. Kolitz Title: Technical Staff The Charles Stark Draper Laboratory Thesis Supervisor: Dimitris J. Bertsimas Title: Boeing Professor of Operations Research Co-Director, Operations Research Center
Disassembling the Nature of Capsid: Biochemical, Genetic, and Imaging Approaches to Assess HIV-1 Capsid Functions

The human immunodeficiency virus type 1 (HIV-1) capsid and its disassembly, or capsid uncoating, has remained an active area of study over the past several decades. Our understanding of the HIV-1 capsid as solely a protective shell has since shifted with discoveries linking it to other complex replication events. The interplay of the HIV-1 capsid with reverse transcription, nuclear import, and integration has led to an expansion of knowledge of capsid functionality. Coincident with advances in microscopy, cell, and biochemistry assays, several models of capsid disassembly have been proposed, in which it occurs in either the cytoplasmic, nuclear envelope, or nuclear regions of the cell. Here, we discuss how the understanding of the HIV-1 capsid has evolved and the key methods that made these discoveries possible.