Miracle-dz/UniFAR-FTUs huggingface dataset:
Emotional or educational debriefing after psychological trauma * Randomised controlled trial

Declaration of interest None. Fundingdetailed in Acknowledgements. Although single-session psychological debriefing is offered as immediate psychological assistance to survivors of all kinds of traumatic events, its efficacy in the prevention of symptoms of post-traumatic stress disorder (PTSD), anxiety or depression is not empirically supported (Litz et al, 2002; Rose et al, 2002; van Emmerik et al, 2002). Some studies even indicate adverse effects (Bisson et al, 1997; Mayou et al, 2000), which have been explained in several ways. It has been argued that the stimulation of emotional ventilation soon after a traumatic event may be too overwhelming for some survivors, whereas a period of rest and reduced talking about the event may in fact be an adaptive response (Ursano et al, 2000). Furthermore, the psychoeducation provided during the debriefing may increase the awareness of stress symptoms that would otherwise not have been noted (Raphael & Meldrum, 1995), or ‘change heroes into patients’. The effects of the constitutive elements of debriefing, i.e. emotional ventilation and psychoeducation, have never been systematically studied. The present randomised controlled trial was designed to assess the efficacy of individual single-session debriefing based on emotional ventilation alone or psychoeducation alone in preventing symptoms of PTSD in relation to a control group that had no debriefing. A secondary question was whether symptoms of acute psychological distress interact with the effect of each debriefing method.
Amplitude variation and multiplet structures: Is PG1605+072 a slow rotator?

The subdwarf B star PG1605+072, with an unusually low log g ~ 5.3, shows a high number of non-radial pulsation modes, making it a promising candidate for asteroseismology. This could allow probing the star's interior to gain important insights in its structure and evolution. Comparison of previous work conducted over the last decade shows clear amplitude variation and hints of frequency variation. We analyse white light photometric data of the Multi-Site Spectroscopic Telescope (MSST) and Whole Earth Telescope (WET) XCov22 campaigns using prewhitening techniques and O-C diagrams. A total of 85 significant frequencies are identified, among them more than 20 frequency sums and harmonics. Moreover, it is shown that the main mode's amplitude varies like a sine with a period of ~630 d, indicative of long-term beating. Strong hints for the existence of frequency multiplets support the hypothesis that PG1605+072 is a slow rotator with V_eq < 0.9 km/s, contrary to previous claims. Existing asteroseismic models mainly suggest that the star possesses a high mass of ~0.7 M_Sun, presuming the main pulsation mode to be radial. This calls for an alternate formation channel.
Long-Term Continuous Treatment with Sildenafil Ameliorates Aging-Related Erectile Dysfunction and the Underlying Corporal Fibrosis in the Rat

Aging-related erectile dysfunction is characterized by a loss of smooth muscle cells (SMCs) and fibrosis in the corpora cavernosa, and functionally by corporal veno-occlusive dysfunction (CVOD). Phosphodiesterase 5 (PDE5A) inhibitors, in part via upregulating inducible nitric oxide synthase (NOS2A), have antifibrotic properties in penile tissues. We aimed to determine whether in the aged rat the chronic long-term treatment with sildenafil ameliorates corporal SMC loss and fibrosis, stimulates NOS2A induction, and corrects the associated CVOD. Aged male rats (20 mo old) received sildenafil in their drinking water (20 mg/kg per day) or plain water for 45 days, and untreated young rats (5 mo old) served as controls (n1⁄4 8 per group). CVOD was assessed by dynamic infusion cavernosometry (DIC). Collagen:SMC (Masson trichrome) and collagen III:I (picrosirius red) ratios, SMC content (alphasmooth muscle actin [ACTA2]), cell proliferation (proliferating nuclear antigen [PCNA]), apoptotic death (TUNEL), and NOS2A induction were measured by histochemistry and immunohistochemistry followed by quantitative image analysis. Collagen content was determined by hydroxyproline assay, and transforming growth factor beta-1 (TGFB1); xanthine oxidoreductase (XDH); ACTA2; NOS2A; and the Rho kinase inhibitor protein tyrosine phosphatase, nonreceptor type 11 (PTPN11), and activator, VAV, were measured by quantitative Western blot. In the aged rats treated with sildenafil, the erectile response by DIC was normalized, and the corporal SMC:collagen ratio and SMC number were increased. In addition, sildenafil reduced the corporal collagen content without affecting the collagen III:I ratio, increased the PCNA:apoptosis ratio, and stimulated NOS2A induction, although there was no effect on XDH, TGFB1, PTPN11, or VAV levels. These data show that long-term PDE5A treatment corrected CVOD in the aged rat and partially reversed the aging-related fibrosis and loss of SMC in the corpora cavernosa without affecting TGFB1 or PTPN11 levels, which are markers of oxidative stress. It may be speculated that similar effects may be achieved with this paradigm in men. aging, apoptosis, cGMP, collagen, corporal veno-occlusive dysfunction, inducible nitric oxide synthase, nitric oxide, PDE5A inhibitors, penis, phosphodiesterases, ROS, smooth muscle, TGFB1
OTT_A_255067 10245..10256

1Department of Oncology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, People’s Republic of China; 2Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, People’s Republic of China; 3Capital Medical University, Beijing 100069, People’s Republic of China; 4Department of General Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, People’s Republic of China; 5Department of Pediatrics, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, People’s Republic of China Purpose: Cervical cancer is the second most prevalent female malignance, and human papillomavirus (HPV) infection is the main pathogenic factor of cervical cancer. Emerging evidence has revealed that a number of long non-coding RNAs (lncRNAs) play critical roles in the tumorigenesis and progression of cervical cancer. The aim of this study was to further investigate the precise role of lncRNA LINC00511 in HPV-negative and HPV-positive cervical cancer cells and explore the potential regulatory mechanism. Methods: The expression of LINC00511 in cervical cancer and cell lines was examined by RT-PCR. Fluorescence in situ hybridization analysis (FISH) assay was performed to detect the localization of LINC00511 in cervical cancer cells. Loss-of-function experiments of LINC00511 by siRNA interference were performed to assess its effects on HPV-negative and HPV-positive cervical cancer cells. Dual-luciferase reporter and RNA immunoprecipitation (RIP) assays were used to identify the target of LINC00511. Relative expression of related proteins was detected using Western blot. Results: Herein, the results showed that LINC00511 was significantly up-regulated in cervical cancer and cell lines and mainly distributed in the cytoplasm of cervical cancer cells. Loss-offunction experiments indicated that silencing of LINC00511 inhibited the proliferation and invasion of both HPV-negative and HPV-positive cervical cancer cells, as well as promoted apoptosis by regulating the Bcl-2/Bax axis and Caspase 3 activation. Bioinformatic analysis, dual-luciferase reporter, and RIP assays showed that LINC00511 was a target of miR-324-5p, while DRAM1 was a direct target of miR-324-5p. The expression of miR-324-5p was downregulated in cervical cancer, while the expression of DRAM1 was up-regulated. Moreover, the expression of LINC00511 was negatively correlated with miR-324-5p expression in cervical cancer tissues and positively correlated with DRAM1. Further, DRAM1 overexpression promoted both HPV-negative and HPV-positive cervical cancer cell proliferation and invasion, which could be reversed by miR-324-5p mimics or si-LINC00511. Conclusion: Collectively, these results suggest that LINC00511 functions as a competing endogenous RNA (ceRNA) to regulate the miR-324-5p/DRAM1 axis, leading to HPVnegative and HPV-positive cervical cancer aggravation.
Energy storage usages: Engineering reactions, <fc>economicâ•’technological</fc> values for electric vehiclesâ•flA technological outlook

School of Electrical Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, Johor, Malaysia Department of Electrical Engineering, The Islamia University Bahawalpur (IUB), Bahawalpur, Punjab, Pakistan College of Engineering and Sciences, Institute of Business Management Sindh, Karachi, Pakistan Department of Electrical Engineering, Khwaja Fareed University of Engineering &Technology (KFUEIT), Rahim Yar Khan, Pakistan Department of Mechanical Engineering, National Taiwan University of Science & Technology, Taipei, Taiwan
in Computer

— Security of any web-application is very important due to its excessive use in daily routine life (such as business, education, health etc). One of these attacks is SQL injection which can give attackers illegal access to the databases. This paper presents the prevention of SQL injection attack by providing query filters to the access to the database by blocking the unusual client through whitelist. The goal of this paper is to provide improved security by developing a method which prevents illegal access to the database
ERASMUS+ as a prospective cluster for RUDN University to strengthen cooperation with EU HEIs

In the global competition, also affecting the higher education sector, universities have to formulate adequate development plans. One of the crucial points of the internationalization strategy of RUDN University is the establishment of clusters in various regions of the globe. Because of its history mostly orientated to developing countries, RUDN University does not have any cluster in Europe, and traditionally its cooperation is focused on the Asian, African continents, and Latin America. The European Union funded programme Erasmus+ represents a crucial tool for RUDN University to enhance its collaboration with European Universities in various forms. The most common ways are the development of academic mobility (Erasmus+ International Credit Mobility), developing transnational projects with European and non-European Universities (Capacity Building in the field of Higher Education), and promoting teaching and research on European studies (Jean Monnet Activities). Through a quantitative analysis, the author shows how these actions of the Erasmus+ programme have contributed to enhancing partnerships and internationalization at home, supporting curricula upgrade, and improving collaboration with
Induction Is TRAIL Dependent Heterologous Bacterial Infection after Sepsis Immune Unresponsiveness to Secondary

Sepsis is the leading cause of death in most intensive care units, and patients who survive the hyperinﬂammation that develops early during sepsis later display severely compromised immunity. Not only is there apoptosis of lymphoid and myeloid cells during sepsis that depletes these critical cellular components of the immune system, but also the remaining immune cells show decreased function. Using a cecal-ligation and puncture (CLP) model to induce intra-abdominal polymicrobial peritonitis, we recently established a link between the apoptotic cells generated during sepsis and induction of sepsis-induced suppression of delayed-type hypersensitivity. The present study extends this earlier work to include a secondary heterologous bacterial infection (OVA 257 -expressing Listeria monocytogenes [LM-OVA]) subsequent to sepsis initiation to investigate sepsis-induced alterations in the control of this secondary infection and the associated naive Ag-speciﬁc CD8 T cell response. We found that CLP-treated wild-type (WT) mice had a reduced ability to control the LM-OVA infection, which was paralleled by suppressed T cell responses, versus sham-treated WT mice. In contrast, CLP-treated Trail 2 / 2 and Dr5 2 / 2 mice were better able to control the secondary bacterial infection, and the Ag-speciﬁc CD8 T cell response was similar to that seen in sham-treated mice. Importantly, administration of a blocking anti-TRAIL mAb to CLP-treated WT mice was able to restore the ability to control the LM-OVA infection and generate Ag-speciﬁc CD8 T cell responses like those seen in sham-treated mice. These data further implicate TRAIL-dependent immune suppression during sepsis and suggest TRAIL neutralization may be a potential therapeutic target to restore cellular immunity in septic patients. The Journal of Immunology , 2011, 187:
University of Birmingham Measurement of physical activity and energy expenditure in wheelchair users

Accurately measuring physical activity and energy expenditure in persons with chronic physical disabilities who use wheelchairs is a considerable and ongoing challenge. Quantifying various free-living lifestyle behaviours in this group is at present restricted by our understanding of appropriate measurement tools and analytical techniques. This review provides a detailed evaluation of the currently available measurement tools used to predict physical activity and energy expenditure in persons who use wheelchairs. It also outlines numerous considerations specific to this population and suggests suitable future directions for the field. Of the existing three self-report methods utilised in this population, the 3-day Physical Activity Recall Assessment for People with Spinal Cord Injury (PARA-SCI) telephone interview demonstrates the best reliability and validity. However, the complexity of interview administration and potential for recall bias are notable limitations. Objective measurement tools, which overcome such considerations, have been validated using controlled laboratory protocols. These have consistently demonstrated the arm or wrist as the most suitable anatomical location to wear accelerometers. Yet, more complex data analysis methodologies may be necessary to further improve energy expenditure prediction for more intricate movements or behaviours. Multi-sensor devices that incorporate physiological signals and acceleration have recently been adapted for persons who use wheelchairs. Population specific algorithms offer considerable improvements in energy expenditure prediction accuracy. This review highlights the progress in the field and aims to encourage the wider scientific community to develop innovative solutions to accurately quantify physical activity in this population.
PPA_A_285440 2541..2549

1General Practice Clinic, 2Medical Commission Family Physician, 3Crown Prince Center for Training & Medical Research, Bahrain Defense Force Hospital, Riffa, Kingdom of Bahrain Objective: This study aimed to have an instrument for assessing Bahrain healthcare. For such purpose, we used the General Practice Assessment Questionnaire (GPAQ-R2) and a modified shorter version of it, GPAQ-R2-BDF. The GPAQ-R2-BDF was modified based on the healthcare system and the cultural behavior in Bahrain. Subjects and Methods: This cross-sectional study was conducted at the general practice (GP) of the Bahrain Defense Force (BDF) Hospital from March 2018 to April 2018. Five hundred and twenty patients visiting the clinics completed the original GPAQ-R2 questionnaire. A validity, reliability, and rotated factor analysis were performed on the original and modified questionnaire. Patients’ characteristics such as age, gender, long-standing health conditions, and employment status were recorded. The score responses of the questionnaire were analyzed, and areas of weakness were identified. Results: The validity, reliability, and correlation matrix values of the original GPAQ-R2 in the GP access and GP practice components were unsatisfactory in BDF hospital assessment. However, the modified GPAQ-R2-BDF revealed higher overall validity, reliability, and correlation matrix, and the rotated factor analysis showed values between 0.704 and 0.928. Furthermore, the reliability values ranged from 0.77 to 0.936. As for patients’ satisfaction scores were highest (~90%) in confidence and enablement, and doctor care but lowest in GP access, and GP practice (~77%) (P<0.001). On the other hand, patients with long-standing health conditions were less satisfied with doctor care, confidence and enablement, and GP access (p<0.05–0.01). Conclusion: The present findings demonstrated high reliability and validity for the GPAQR2-BDF, which supports its use to assess Bahrain’s GP healthcare system. Furthermore, such an instrument should be adapted in a longitudinal research design to assess Bahrain’s healthcare system better. Lastly, BDF hospital healthcare clinics showed concerns in GP access, GP practice, and quality services for patients with long-standing health conditions requiring strategic interventions to reach better quality services.
CD133 Epithelial Prostate Stem Cells Express Low Levels of Active Androgen Receptor

Stem cells are thought to be the cell of origin in malignant transformation in many tissues, but their role in human prostate carcinogenesis continues to be debated. One of the conflicts with this model is that cancer stem cells have been described to lack androgen receptor (AR) expression, which is of established importance in prostate cancer initiation and progression. We re-examined the expression patterns of AR within adult prostate epithelial differentiation using an optimised sensitive and specific approach examining transcript, protein and AR regulated gene expression. Highly enriched populations were isolated consisting of stem (a2b1 HI CD133), transiently amplifying (a2b1 HI CD133) and terminally differentiated (a2b1 LOW CD133) cells. AR transcript and protein expression was confirmed in a2b1 HI CD133 and CD133 progenitor cells. Flow cytometry confirmed that median (6SD) fraction of cells expressing AR were 77% (66%) in a2b1 HI CD133 stem cells and 68% (612%) in a2b1 HI CD133 transiently amplifying cells. However, 3-fold lower levels of total AR protein expression (peak and median immunofluorescence) were present in a2b1 HI CD133 stem cells compared with differentiated cells. This finding was confirmed with dual immunostaining of prostate sections for AR and CD133, which again demonstrated low levels of AR within basal CD133 cells. Activity of the AR was confirmed in prostate progenitor cells by the expression of low levels of the AR regulated genes PSA, KLK2 and TMPRSS2. The confirmation of AR expression in prostate progenitor cells allows integration of the cancer stem cell theory with the established models of prostate cancer initiation based on a functional AR. Further study of specific AR functions in prostate stem and differentiated cells may highlight novel mechanisms of prostate homeostasis and insights into tumourigenesis. Citation: Williamson SC, Hepburn AC, Wilson L, Coffey K, Ryan-Munden CA, et al. (2012) Human a2b1 HI CD133 Epithelial Prostate Stem Cells Express Low Levels of Active Androgen Receptor. PLoS ONE 7(11): e48944. doi:10.1371/journal.pone. 0048944 Editor: Yao Liang Tang, University of Cincinnati, United States of America Received July 22, 2012; Accepted October 2, 2012; Published November 7, 2012 Copyright: 2012 Williamson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: Work was supported by Newcastle upon Tyne NHS Trustees and Cancer Research UK. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * E-mail: Rakesh.Heer@ncl.ac. uk
Optimal Location and Sizing of Stormwater Storage Units: case study in Bogotá

Flooding in urban areas may result in costly damage, and affect population safety and the proper functioning of cities. Controlling and managing urban stormwater involves adapting the urban drainage network to reduce peak runoff and prevent flooding impacts. This work presents an optimization model to find the best solution for implementing rainwater storage units (SUs). The optimization model was used to determine the optimal location and size of the SUs and their outflow orifice sizes, in order to minimize SU construction, maintenance and flood damage costs. Flood damage costs were assessed based on the depth of urban floodwater and the type of buildings. EPA-SWMM was used to simulate the hydrologic and hydraulic behavior of the drainage system and a simulated annealing algorithm was implemented to solve the optimization model. The developed methodology was tested on a case study inspired by a real urban area located in Bogotá, Colombia.
Peace, Security and other Developmental Problems in Nigeria: Taxation as the Light at the End of the Tunnel

The elusive and precarious nature of peace, security and development in Nigeria today is at an alarming rate. Series of criminality and criminal tendencies in form of religious, economic as well as socio-political upheavals now takes the central stage in the Nigerian polity devoid of any known common solutions. Using doctrinal research method, this paper examines the issue of peace, security and developmental problems in Nigeria. The paper posits and argues that using and applying functional as well as equitable tax on the derivative revenue foundation and sharing formula by Nigerian government, most of the associated problems with peace, security and development in Nigeria will be a thing of the past. To actualise this position, the paper proffers some practical solutions in form of recommendations.
Online learning and fusion of orientation appearance models for robust rigid object tracking. In: 2013 10th IEEE International

—We present a robust framework for learning and fusing different modalities for rigid object tracking. Our method fuses data obtained from a standard visual camera and dense depth maps obtained by low-cost consumer depths cameras such as the Kinect. To combine these two completely different modalities, we propose to use features that do not depend on the data representation: angles. More speciﬁcally, our method combines image gradient orientations as extracted from intensity images with the directions of surface normals computed from dense depth ﬁelds provided by the Kinect. To incorporate these features in a learning framework, we use a robust kernel based on the Euler representation of angles. This kernel enables us to cope with gross measurement errors, missing data as well as typical problems in visual tracking such as illumination changes and occlusions. Additionally, the employed kernel can be efﬁciently implemented online. Finally, we propose to capture the correlations between the obtained orientation appearance models using a fusion approach motivated by the original AAM. Thus the proposed learning and fusing framework is robust, exact, computationally efﬁcient and does not require off-line training. By combining the proposed models with a particle ﬁlter, the proposed tracking framework achieved robust performance in very difﬁcult tracking scenarios including extreme pose variations.