Miracle-dz/UniFAR-FTUs huggingface dataset:
Socrates’ Mythological Role in Plato’s Theaetetus

Plato, as a poet, employs muthos extensively to express his philosophical dialectical development, so the majority of his dialogues are comprised of muthoi. We cannot separate his muthos from his philosophical thought, since the former has great influence in the latter. So the methodology of this paper is first to discuss the dialogue Theaetetus to find out why he compares Socrates to the Greek goddess Artemis; then his concept of Maieutikē will be investigated. At the beginning of Plato’s Theaetetus, Socrates first likens himself to the goddess Artemis, who, though unmarried, has a duty to assist women in labour. Socrates’ role, as Plato portrays, is the same as that of Artemis; and the technē he possesses is Maieutikē, which is to assist his students in giving birth to their mental offspring. This paper will focus on discussion on the Socratic mythological role in Platonic interpretation and dialectics so as to reveal the philosophical meaning of Socratic ignorance. Keywords—Artemis, Ignorance, Logos, Maieutikē, Muthos.
Genetic Engineering of Solanum tuberosum L. to Enhance Resistance Against Abiotic Stresses: A Review

Potato is a family of the Solanaceae, an enormous plant family with more than 3000 varieties [1]. More than 374,463,885 million tones of potatoes are produced worldwide [2]. As the global population reaches to 9.7 billion by 2050, the potato will play important role in securing global food resources. In Turkey, potato accounts for 3% of the gross national agricultural product (GNP), whereas it is about 3.1% in the EU-27 countries, hence contributing significantly to Turkish economy. It was cultivated on an area of 172,000 ha with the production of 3.9 million tons of potatoes. Central Anatolia including Nigde shares more than 60% potato production in this regard [3]. Potato has high amount of protein after soybean; patatin is the dominant storage protein [4]. The tubers of potato contain important dietary origin of starch, protein, vitamins and antioxidants [5]. Potato protein contains great biological value (BV) with a BV of 90-100 in contrast with whole egg (100) [6].
Resistance in Murine B Lymphoma Cells Distinct Molecular Mechanisms of Fas

A panel of murine B lymphoma cell lines, which express different levels of Fas, was extensively studied for sensitivity to Fas-mediated death signals via an anti-Fas mAb and Fas ligand-bearing cell lines. Expression of the Fas receptor on the B lymphoma cell lines did not correlate with their capacity to undergo Fas-mediated apoptosis. Moreover, Fas-associated death domain protein recruitment to the death-inducing signaling complex (DISC) complex occurred in all cell lines expressing Fas, regardless of whether they were sensitive to Fas-mediated death. Interestingly, the protein synthesis inhibitor, cycloheximide, and protein kinase C inhibitors, such as bisindolylmaleimide, rendered one of the resistant cell lines, CH33, sensitive to signals from the Fas receptor, although the levels of Fas were unchanged. This suggests that constitutive PKC activation plays a role in Fas resistance, perhaps by up-regulating NF- k B or Bcl-2 family members. Interestingly, CH33 demonstrated caspase 8 activity upon engagement of the Fas receptor in the absence of pharmacological manipulation, suggesting that the block in apoptosis is downstream of the DISC complex. In contrast, the fact that Fas-associated death domain protein was recruited to the DISC complex in other resistant lines, such as WEHI-231, with no caspase 8 activation indicates that these cells may be blocked within the DISC complex. Indeed, Western blot analysis showed that WEHI-231 expressed an isoform of FLICE-like inhibitory protein (cFLIP L ), an antiapoptotic protein within the DISC. These studies provide evidence that murine B lymphoma cells utilize different molecular mechanisms along the Fas-signaling cascade to block apoptosis. The Journal of Immunology, 2000, 165: 1854–1862. , gift Dr. Jose Zamorano, American Red Cross). addition of 2 m l of gel-loading buffer (250 mM Tris-HCl, pH 7.5, 0.2% bromophenol and glycerol), samples were electrophoresed on a 6% polyacryl- amide gel. gel was dried and subjected to autoradiography.
Path Planning and Path Following Control for Mechanical Systems

The goal of this thesis is to provide systematic means to plan and follow a path for mechanical systems. Therefore, this thesis is divided into two main parts, one for each of these problems. Firstly, the path planning problem is introduced and then solved by using the so-called Rapidly Exploring Random Tree algorithm. To improve the so-found paths, a modification is introduced which renders the solutions optimal with respect to a specific criterion. To avoid high computation times, the algorithm was simplified by consistent assumptions on the mechanical system. Secondly, a path following controller is derived to follow the calculated path in presence of disturbances and to account for modelling errors. Using this controller, it is possible to control the velocity along the path with one control law and a second control law is defined to account for deviations from the path. To the best of the authors knowledge, this controller, unlike for any other approach, can be specified in fixed coordinates. This particularly simple approach is applicable to a wide variety of systems, in particular mechanical systems. In simulation the proposed concepts were tested for a number of mechanical systems. To underline its practical feasibility the path following approach was validated using a parallel kinematic robot.
USP14 haploinsu ciency ameliorates Alzheimer’s disease-like pathology in APP/PS1 mice

Hua Xu Guangzhou Medical University Xueheng Wu Guangzhou Medical University Lu Liang Guangzhou Medical University Haoyu Chen Guangzhou Medical University Jia Xu Guangzhou Medical University Wanyan Hu Guangzhou Medical University Xinci Li Guangzhou Medical University Qin Liu Guangzhou Medical University Xuejun Wang University of South Dakota Chang-E Zhang Guangzhou Medical University Jinbao Liu (  jliu@gzhmu.edu.cn ) Guangzhou Medical University https://orcid.org/0000-0003-2220-2407
Current advances in paleohistology : a tribute to a generation of French paleohistologists

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Current advances in paleohistology : a tribute to a generation of French paleohistologists Michel Laurin, Jorge Cubo
A Review On data mining approach for network security

- Over the last decade, we have become too much technology dependent. Now-a-days we rely on networks to receive emails, banking, stock price, news and online shopping. The need for protecting files in computer systems became more evident with the advent of shared systems. The need became even more severe for systems being accessed over a public network, the Internet. Information in transit must be protected from unauthorized release and changes. The connection itself must be securely established and maintained. The term network security defines that, Network is interconnection (or link) for example network of computers and Security is the freedom from danger or anxiety so Network Security is about securing and protecting the network (externally and internally) from Distributed Denial of Service attacks, rapidly spreading viruses, self-replicating worms, destructive malware and other attacks. Network security begins with authorization and authentication. Organizations are spending billions of dollars just to make their network secure and protect their data from outside and inside attack. However securing and protecting today’s complex network in not so easy, it is challenging and demanding [1]. There are many traditional security solutions existing but these solutions do not perform well. here we discuss a survey on various proposed security solution for data.
RRU_A_207843 149..155

1Department of Pathology and Microbiology, King Abdullah University Hospital, Irbid, Jordan; 2Jordan University of Science and Technology, Irbid, Jordan; 3Department of Teacher Education, University of Texas, El Paso, TX, USA; 4Department of Public Health, Jordan University of Science and Technology, Irbid, Jordan; 5Division of Nephrology, Department of Medicine, Jordan University of Science and Technology, Irbid, Jordan; 6Attasami Diagnostic Center, Tripoli, Libya; 7Division of Urology, Jordan University of Science and Technology, Irbid, Irbid; 8Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada Background: High-grade prostatic intraepithelial neoplasia (HGPIN) is the most likely
Tau in Alzheimer’s Disease

probes for the imaging of tau have been developed. Several compounds including [18F] THK-523, [18F]THK-5105, [18F]T807, [18F]T808, and [11C]PBB3 were tested clinically. The results showed their feasibility for imaging tau aggregates for the diagnosis of AD [17]. Mutations of Tau are
OP-JPEP140094 391..397

Objective To summarize recent research on negative behavioral and cognitive outcomes following early childhood traumatic brain injury (TBI). Methods Topical review of the literature published since the year 2000 examining behavioral and cognitive difficulties following TBI in early childhood. Results Research findings from the reviewed studies demonstrate a variety of negative behavioral and cognitive outcomes following TBI in childhood, particularly for children <5 years of age. Negative outcomes include problems with externalizing behaviors, attention, language, and cognitive functioning (e.g., IQ, executive functioning). Furthermore, negative outcomes have been shown to persist up to 16 years following the injury. Conclusions The empirical studies reviewed demonstrate the increased risk for negative behavioral and cognitive outcomes following early childhood TBI. Furthermore, the review highlights current strengths and limitations of TBI research with young children and the need for multidisciplinary work examining outcomes for this vulnerable pediatric population.
The transition from STEM to STEAM

Over the last few decades the Accreditation Board for Engineering and Technology (ABET) has emphasized the importance of science, technology, engineering and mathematics (STEM) for the undergraduate engineering curricula. In the recent years, however, another component has been added to it, and that is, the Arts, thus transforming STEM to STEAM. The present paper addresses the positive aspects of adding arts to the STEM program, especially in engineering design as well as for engineering practitioners working on a global context. The arts, including literature, music and fine arts, improve our engineering ‘reasoning’(left brain) by engaging the intelligence of our emotions (right brain), and hence add that extra touch to our engineering design that customers from different global cultures appreciate. Product design that engages emotions motivate customers to make the final purchase. For the engineers of today, understanding and appreciating another culture is not anymore a choice but a necessity. The slogan of the 1960s, ‘think globally but act locally’ is changed today to ‘think globally and act globally’. The transition from STEM to STEAM can have that global impact by leveraging the arts as a way to communicate and connect globally.
Comparative Analysis of K-Means using MapReduce

: Continuous growth of digital data has led to concentration in the data mining technique . The actual purpose of data mining is to analyze the larger data set to extract knowledge and interesting patterns. The cluster analysis is an important data partitioning process which distribute data items into different groups (clusters), so that the data items in each cluster can share the common characteristics. Data collected in real time scenarios are more often semi structured and unstructured, that needs to be processed to extract hidden knowledge from it. Here the clustering technique comes into the scenes, there are various clustering algorithms, k Mean is the simplest and popular unsupervised learning algorithm, which has solved many well know clustering problem. K Mean clustering algorithm produces a specific member of disjoint cluster, starting from randomly selected cluster centers. In this paper we have implemented the k mean clustering algorithm for different distance metrics in the MapReduce programming model running in Hadoop distributed environment.
Macro meteorology, electricity and micro-gravity of dry landscape in Spain

The study of the traditional and contemporary dry landscapes in Spain is divided in three categories: macro meteorology, electricity and micro-gravity. Traditional interventions in arid landscape are: fog catchers, crop hollows and salt evaporation ponds. The research is focused on analysing the normal scale (humans, animals, plants and machines), micro-scale (unicellular beings) and macro-scale (thermodynamic parameters). Contemporary landscape architecture is analysed through red, blue and green infrastructures. Firstly, red infrastructure (dehesa) is the large area of the fertile red soil with green meadow islands used in the park, gardens and green-roof of the Caja Badajoz new headquarters project in Western Spain. Isolated spots concentrate their energy resources providing sustainable landscape for humans, animals and plants and what we contemplate is an archipelago of holm oaks, cork oaks and olives trees over the extensive red humus-rich area underneath the entire unpaved surface, where the potential for vegetation growth depends on the weather conditions. Secondly, blue infrastructure (dry meadows) is the rainwater storage which is distributed under the squares and gardens of horticultural therapy of the Alzheimer Center Reina Sofía Foundation project in Central Spain. Landscape design has been carefully planned to separate plantation areas depending on the amount of water. It consists of rainwater harvesting storages such as an underground water tank (3x3x3 m3) under the public square and drainage cells (50x60x5 cm3) and under the private gardens of the care patient area. Thirdly, green infrastructure (dry-hot valley) is the concentration of plantations which is located in the urban parks, car parks and interior gardens of Córdoba Airport extension project in Southern Spain. The sort of invisibility of the infrastructure employed in the design of landscape airport takes as reference the other invisible world of micro-organisms, subtly insinuates on the free trade treaties and market forces. Despite the scientific classification that maintains apart the studies of electric fields and microbiology, the development of new infrastructures keeps those boundaries blurred. These systems translate the abstract world of electricity or microbiology to the concrete world of landscape architecture and infrastructure design using biological and economic knowledge to allow the subsistence of the arid Spanish landscapes.
Ginès P. Safety of two different doses of simvastatin plus rifaximin in decompensated cirrhosis

BACKGROUND: Statins have beneficial effects on the intrahepatic circulation and decrease portal hypertension, while rifaximin modulates gut microbiome and may prevent bacterial translocation in cirrhosis. Therefore, this drug combination may be of therapeutic benefit in decompensated cirrhosis. However, there is concern regarding safety of statins in patients with decompensated cirrhosis. We assessed the safety of two different doses of simvastatin, in combination with rifaximin, in patients with decompensated cirrhosis. METHODS: We performed a multicenter, double-blind, randomized, placebo-controlled trial in patients with decompensated cirrhosis, Child-Pugh B and C, that were randomly assigned to receive simvastatin 40mg/day plus rifaximin 1,200mg/day(n=16) , simvastatin 20mg/day plus rifaximin 1,200mg/day (n=14) or placebo of both medications (n=14) for 12 weeks. Primary endpoint was development of liver or muscle toxicity, as defined by changes in liver transaminases (AST, ALT), alkaline phosphastase and creatine kinase (CK) levels. ITT and PP analysis were performed. FINDINGS: Patients in the simvastatin 40mg/day group but not in the simvastatin 20mg/day group showed a significant increase in AST, ALT and CK levels during treatment, as compared to placebo (191 vs. 62IU/L, 96 vs 35 IU/L and 1160 vs. 152 IU/L for AST, ALT and CK, respectively; p<0.001, p<0.001 and p=0.016) . Moreover, 3 patients (19%) in the simvastatin 40mg/day group developed significant liver and muscle toxicity consistent with rhabdomyolysis. INTERPRETATION: Treatment with simvastatin 40mg/day plus rifaximin in patients with decompensated cirrhosis appears to be associated with significant frequency of adverse events, particularly rhabdomyolysis. By contrast, the dose of simvastatin 20mg/day plus
Examining the implementation of potable water reuse in sewersheds of Southeastern Spain

ABSTRACT Sewage management is a key issue within circular economy and climate change scenario. Ensuring water supply is a challenge on a global scale. Numerous projects for potable water reuse (indirect or direct) are carried out in different parts of the world. This territorial study analyzes the situation of sewage in the Campo de Cartagena – Mar Menor region (Southeastern Spain), an area with semi-arid Mediterranean climate with structural scarcity of water and high competition for the uses of water. With data provided by ESAMUR, the evolution of its performance, use of reclaimed water and the presence of pollutants at the entrance and exit of the STPs are examined. It concludes that the concentrations of parameters contemplated in Directive 91/271/EEC are met regardless of the greater or lesser presence in the inlet flow. It is convenient to advance with potable reuse pilot projects and greater investments.
Mutation accumulation opposes polymorphism: supergenes and the curious case of balanced lethals

Supergenes offer spectacular examples of long-term balancing selection in nature, but their origin and maintenance remain a mystery. Reduced recombination between arrangements, a critical aspect of many supergenes, protects adaptive multi-trait phenotypes but can lead to mutation accumulation. Mutation accumulation can stabilize the system through the emergence of associative overdominance (AOD), destabilize the system, or lead to new evolutionary outcomes. One outcome is the formation of maladaptive balanced lethal systems, where only heterozygotes remain viable and reproduce. We investigated the conditions under which these different outcomes occur, assuming a scenario of introgression after divergence. We found that AOD aided the invasion of a new supergene arrangement and the establishment of a polymorphism. However, this polymorphism was easily destabilized by further mutation accumulation, which was often asymmetric, disrupting the quasi-equilibrium state. Mechanisms that accelerated degeneration tended to amplify asymmetric mutation accumulation between the supergene arrangements and vice-versa. As the evolution of balanced lethal systems requires symmetric degeneration of both arrangements, this leaves only restricted conditions for their evolution, namely small population sizes and low rates of gene conversion. The dichotomy between the persistence of polymorphism and degeneration of supergene arrangements likely underlies the rarity of balanced lethal systems in nature. This article is part of the theme issue ‘Genomic architecture of supergenes: causes and evolutionary consequences’.
The relevance of chromatin architecture to genome rearrangements in Drosophila

DNA within chromosomes in the nucleus is non-randomly organized into chromosome territories, compartments and topologically associated domains (TADs). Chromosomal rearrangements have the potential to alter chromatin organization and modify gene expression leading to selection against these structural variants. Drosophila pseudoobscura has a wealth of naturally occurring gene arrangements that were generated by overlapping inversion mutations caused by two chromosomal breaks that rejoin the central region in reverse order. Unlike humans, Drosophila inversion heterozygotes do not have negative effects associated with crossing over during meiosis because males use achiasmate mechanisms for proper segregation, and aberrant recombinant meiotic products generated in females are lost in polar bodies. As a result, Drosophila populations are found to harbour extensive inversion polymorphisms. It is not clear, however, whether chromatin architecture constrains which inversions breakpoints persist in populations. We mapped the breakpoints of seven inversions in D. pseudoobscura to the TAD map to determine if persisting inversion breakpoints are more likely to occur at boundaries between TADs. Our results show that breakpoints occur at TAD boundaries more than expected by chance. Some breakpoints may alter gene expression within TADs supporting the hypothesis that position effects contribute to inversion establishment. This article is part of the theme issue ‘Genomic architecture of supergenes: causes and evolutionary consequences’.
Enteroinvasive Escherichia coli vs. Shigella £exneri :h ow di¡erent patterns of gene expression a¡ect virulence

Important features of the enteroinvasive Escherichia coli (EIEC) phenotype and gene expression likely to confer EIEC with a lower ability to cause disease than Shigella flexneri were described here for the first time. To confirm the lower pathogenicity of EIEC, we have analyzed the keratoconjunctivitis developed in guinea-pigs with EIEC or S. flexneri. Shigella flexneri induced a more pronounced proinflammatory response, whereas EIEC induced a mild form of the disease. EIEC showed a significantly less efficient cell-to-cell Caco-2 dissemination when compared with S. flexneri. Plaques formed by EIEC during intercellular spreading were four times smaller than those formed by S. flexneri. At the molecular level, the lower expression of virulence genes by EIEC during infection of Caco-2 cells highlighted the importance of effective gene transcription for bacterial pathogenicity.