Miracle-dz/UniFAR-FTUs huggingface dataset:
Final overall survival (OS) in PROpel: Abiraterone (abi) and olaparib (ola) versus abiraterone and placebo (pbo) as first-line (1L) therapy for metastatic castration-resistant prostate cancer (mCRPC).

LBA16 Background: PROpel (NCT03732820) met its primary endpoint showing significant investigator-assessed radiographic progression-free survival (rPFS) benefit for patients with mCRPC treated with abi + ola vs abi + pbo in the 1L setting (hazard ratio [HR] 0.66, 95% confidence interval [CI] 0.54–0.81, P< 0.001, data cut-off: 7/30/2021). Sensitivity analysis by blinded independent central review was consistent. A trend toward OS benefit with abi + ola was observed at the time of the primary rPFS analysis (28.6% maturity, HR 0.86, 95% CI 0.66–1.12) and a subsequent interim analysis (40.1% maturity, HR 0.83, 95% CI 0.66–1.03). We report OS and safety from the pre-planned final analysis (data cut-off: 10/12/2022). Methods: PROpel is a randomized, double-blind phase 3 trial of 1L therapy for patients with mCRPC eligible for abiraterone. Patients were prospectively assessed for homologous recombination repair mutation (HRRm) status using tumor tissue (FoundationOne CDx) and/or circulating tumor DNA (ctDNA; FoundationOne Liquid CDx) tests after randomization 1:1 to ola (300 mg twice daily [bid]) or pbo, and abi (1000 mg once daily) plus prednisone/prednisolone (5 mg bid). Treatment continued until radiographic disease progression, unacceptable toxicity or withdrawal of consent. OS was a key secondary endpoint (2-sided boundary for significance 0.0377). Aggregate results from tumor tissue and ctDNA tests were used to assign patients to HRRm/BRCAm subgroups. Results: Patient (n = 796) characteristics (including prior docetaxel, site of metastasis, symptom score and HRRm status) were generally balanced. There was a consistent trend toward OS benefit in the intention-to-treat (ITT) population with abi + ola vs abi + pbo (maturity 47.9%, HR 0.81, 95% CI 0.67–1.00, P= 0.0544), with median OS 42.1 months (m) vs 34.7 m, respectively. OS medians and HRs for HRRm, non-HRRm, BRCAm and non-BRCAm subgroups all favored abi + ola vs abi + pbo. In the abi + ola arm the most common Grade ≥3 adverse event was anemia (16.1%). Conclusions: At the prespecified final analysis in PROpel, abi + ola prolonged OS by > 7 m vs standard-of-care abiraterone (abi + pbo) in the ITT population. The median OS of > 42 m is the longest median reported to date in a phase 3 trial in 1L mCRPC. Consistent with rPFS results, a trend toward OS benefit was observed in HRRm, non-HRRm, BRCAm and non-BRCAm subgroups with greatest benefit in the BRCAm subgroup. No new long-term safety issues were identified. These results support the use of abi + ola in 1L mCRPC. Clinical trial information: NCT03732820 . [Table: see text]
How CD4+ T Cells Transcriptional Profile Is Affected by Culture Conditions: Towards the Design of Optimal In Vitro HIV Reactivation Assays

Most of the current assays directed at the investigation of HIV reactivation are based on cultures of infected cells such as Peripheral Blood Mononuclear Cells (PBMCs) or isolated CD4+ T cells, stimulated in vitro with different activator molecules. The culture media in these in vitro tests lack many age- and donor-specific immunomodulatory components normally found within the autologous plasma. This triggered our interest in understanding the impact that different matrices and cell types have on T cell transcriptional profiles following in vitro culture and stimulation. Methods: Unstimulated or stimulated CD4+ T cells of three young adults with perinatal HIV-infection were isolated from PBMCs before or after culture in RPMI medium or autologous plasma. Transcriptomes were sequenced using Oxford Nanopore technologies. Results: Transcriptional profiles revealed the activation of similar pathways upon stimulation in both media with a higher magnitude of TCR cascade activation in CD4+ lymphocytes cultured in RPMI. Conclusions: These results suggest that for studies aiming at quantifying the magnitude of biological mechanisms under T cell activation, the autologous plasma could better approximate the in vivo environment. Conversely, if the study aims at defining qualitative aspects, then RPMI culture could provide more evident results.
The asymptotic giant branch evolution of intermediate-mass stars as a function of mass and composition. I - Through the second dredge-up phase

The asymptotic giant branch evolution of stars prior to the onset of thermal pulses is found to be highly sensitive to both initial composition and total stellar mass. Models investigated have masses in the range 3--11 M/sub sun/ and initial compositions of (Y,Z) = (0.28, 0.001), (0.28, 0.01), (0.28, 0.02), (0.28, 0.03), (0.20, 0.02), (0.36, 0.02), and (0.20, 0.001). The effects produced by varying the overall rate of neutrino emission and by varying the size of the mixing length in convective regions are studied; the role played by convective overshoot, semiconvection, and the energy cost of mixing across the hydrogen-helium discontinuity are discussed. a general description of the evolutionary behavior of our models from the start of the asymptotic giant branch to the first major thermal pulse is also presented.The inward advance of the base of the convective envelope results in a reduction in the size of the hydrogen-exhausted core for stellar masses in a specific range: M/sub UP/> or =M/sub asterisk/> or =M/sub CRIT/. The magnitudes of both M/sub CRIT/ and M/sub UP/ (defined as the minimum mass for nondegenerate carbon ignition) depend on the initial composition in ways that can be approximated analytically. The final size of themore » hydrogen-exhausted core that results after the dredge-up phase is, for a given initial mass, larger in models with a lower A or higher Y. The abundance changes that occur as a result of dredge-up are, for a given mass, greater in models with a lower Z or higher Y. Typically, /sup 4/He and /sup 14/N are enhanced while /sup 1/H, /sup 12/C, and /sup 16/O are depleted. For the most massive models undergoing dredge-up, significant enhancements in /sup 18/O also occur. « less
Development of Multidisciplinary Care Model With Participatory Action Research for Heart Failure Clinic in Bangkok, Thailand

Background : Quality of care improvements is a challenge when resources are limited. In this participatory action research (PAR) study, we created a multidisciplinary care model (MCM) for heart failure clinic at a hospital in Bangkok, Thailand, and evaluated quality performance measures and clinical outcomes. Methods : Using the PAR framework, this study included: 1) identi ﬁ cation of problems and planning solutions with providers, 2) development of the MCM, 3) implementation of the MCM, 4) evaluation of quality process and outcome measures among heart failure patients at the follow-up conducted 6 months after implementation of the MCM, and 5) post-MCM survey. Results : Information management of patient data, redundant work and communication, and ineffective work ﬂ ow were the main problems identi ﬁ ed. Providers suggested initiating a patient database, modifying the electronic health records, and developing an institutional map for heart failure care. Outcome measures were studied among 100 patients (mean age ¼ 61.92 years, SD ¼ 15.75; mean left ventricular ejection fraction ¼ 31.15%, SD ¼ 7.89). The mean guideline adherence indicator increased signi ﬁ cantly (p ¼ 0.007) from baseline (87.50 ± 22.14%) to follow-up (94.50 ± 15.54%). At follow-up, there was a signi ﬁ cant reduction for risk of heart failure hospitalization (RR: 0.761, 95% CI: 0.652 to 0.889). Most study participants agreed that all MCM components could solve existing problems with heart failure care. Conclusion : The PAR strategy used to develop the MCM for this heart failure clinic with limited resources was feasible and led to quality-of-care improvements.
Photocatalytic removal of imidacloprid containing frequently applied insecticide in agriculture industry using Co3O4 modified MoO3 composites

Water pollution caused by the frequent utilization of pesticides in the agriculture industry is one of the major environmental concerns that require proper attention. In this context, the photocatalytic removal of pesticides from contaminated water in the presence of metallic oxide photocatalysts is quite in approach. In the present study, Orthorhombic MoO3 has been modified with varying amount of cobalt oxide through wet impregnation for the removal of imidacloprid and imidacloprid-containing commercially available insecticide. The solid-state absorption response and band gap evaluation of synthesized composites revealed a significant extension of absorption cross-section and absorption edge in the visible region of the light spectrum than pristine MoO3. The indirect band gap energy varied from ∼2.88 eV (MoO3) to ∼2.15 eV (10% Co3O4-MoO3). The role of Co3O4 in minimizing the photo-excitons’ recombination in MoO3 was studied using photoluminescence spectroscopy. The orthorhombic shape of MoO3 was confirmed through X-ray diffraction analysis and scanning electron microscopy. Moreover, the presence of distinct absorption edges and diffraction peaks corresponding to Co3O4 and MoO3 in absorption spectra and XRD patterns, respectively verified the composite nature of 10% Co3O4-MoO3. The photocatalytic study under natural sunlight irradiation showed higher photocatalytic removal (∼98%) of imidacloprid with relatively higher rate by 10% Co3O4-MoO3 composite among all contestants. Furthermore, the photocatalytic removal (∼93%) of commercially applied insecticide, i.e., Greeda was also explored.
The XY-centring algorithm for the dual LMI problem: a new approach to fixed-order control design

Many fixed-order suboptimal control problems with stability, performance and robustness specifications can be reduced to a search for a matrix X > 0 satisfying a linear matrix inequality (LMI) while X −1 satisfies another LMI. This paper defines a certain class of these problems we shall call the ‘dual LMI problem’, and a computational algorithm to solve our dual LMI problem is given. Properties and limitations of the algorithm are discussed in comparison with the existing algorithm (the min/max algorithm). An extension to optimal control problems is provided. Numerical examples for the fixed-order stabilization problem and the static output feedback linear quadratic optimal control problem demonstrate the applicability of the proposed algorithm.
Memory-Enhancing and Antioxidant Activities of the Hydroethanolic Leave Extract of Piliostigma reticulatum (Fabaceae) in the Monosodium Glutamate-Induced Alzheimer's Disease Model

Background: Piliostigma reticulatum (Fabaceae) is a plant used in Cameroon for the treatment of madness and migraine. Aims and Objectives: This study aims to evaluate the memory-enhancing and antioxidant activities of the hydroethanolic leaves extract of PR in the monosodium glutamate-induced Alzheimer's disease model. Materials and Methods: The Y-maze, Radial-arm maze and Novel object recognition tests were used to assess short, and long-term memory. At the end of the experiments, the brains of mice were scavenged for biochemical and histological analysis. Results: It was observed that the hydroalcoholic extract of PR leaf significantly reversed the percentage of spontaneous alternation compared to the negative control group at the different doses tested (p<0.01; p<0.001) in the Y-maze test. In the radial arm maze test, the extract significantly (p<0.001) reduced the time spent consuming the bait, the number of reference memory and working memory errors at all doses. The treatment of animals with hydroethanolic extract of PR resulted in a significant increase in the discrimination index (p<0.001) in the unfamiliar object recognition test. In addition, the extract significantly (p < 0.01); p < 0.001) decreased acetylcholinesterase activity,and MDA levels at all tested doses; and significantly (p < 0.05; p < 0.001) increased SOD level and Catalase activity in comparison to the negative control group. The histological analysis showed that the extract of Piliostigma reticulatum protected the different structures of the hippocampus against damage caused by monosodium glutamate. Conclusion : The memoryenhancing induced by the hydroethanolic leaves extract of Piliostigma reticulatum could be due to his antioxidant and anticholinesterase properties. These effects could justify the use of this plant to manage nervous system affections.
Extrahepatic Replication Sites of Hepatitis E Virus (HEV)

Hepatitis E virus (HEV) is an emerging viral disease known to cause acute viral hepatitis globally. Various genotypes of HEV have been identified that produce genotype specific lesions depending on the HEV targeted population. Pregnant or immunosuppressed individuals develop significantly more severe hepatitis E in comparison to the general population. In the last 40 years, we discovered that the tropism of HEV is not restricted to the liver, and virus replication was demonstrated in multiple organs. Out of the 10 body systems described in humans, HEV produces lesions causing a broad range of extrahepatic clinical manifestations in each of them. Affected body systems include nervous and musculoskeletal, cardiovascular, digestive, endocrine, integumentary, renal, respiratory, immune, and reproductive systems producing systemic lesions. All extrahepatic signs are caused by either direct HEV replication in these tissues, or indirectly by various immune mediated mechanisms. Extrahepatic replication features of HEV allowed it to cross the placental barrier, blood–brain barrier (BBB), and blood–testis barrier (BTB) that do not typically grant entry to viruses in general. Thus, in this review, we summarized the extrahepatic replication sites of HEV, listed the body systems where HEV invaded, and described multiple animal models including immunocompetent and immunosuppressed that were used to study the extrahepatic replication sites of HEV.
Modeling Volatility Asymmetries: A Bayesian Analysis of a Class of Tree Structured Multivariate GARCH Models

A new class of multivariate threshold GARCH models is proposed for the analysis and modelling of volatility asymmetries in financial time series. The approach is based on the idea of a binary tree where every terminal node parametrizes a (local) multivariate GARCH model for a specific partition of the data. A Bayesian stochastic method is developed and presented for the analysis of the proposed model consisting of parameter estimation, model selection and volatility prediction. A computationally feasible algorithm that explores the posterior distribution of the tree structure is designed using Markov chain Monte Carlo stochastic search methods. Simulation experiments are conducted to assess the performance of the proposed method, and an empirical application of the proposed model is illustrated using real financial time series. Copyright Royal Economic Society 2007
How Does Instability Affect Bench Press Performance? Acute Effect Analysis with Different Loads in Trained and Untrained Populations

(I) The execution of different sports involves a significant number of throws, jumps, or direction changes, so the body must be as stable as possible while performing a specific action. However, there is no classification of unstable devices and their influence on performance variables. Furthermore, the effect on athletes’ experience using instability is unknown. (II) The aim of this study was to analyze the power and speed parameters in bench press with different loads and unstable executions: (1) stable (SB), (2) with asymmetric load (AB), (3) with unstable load (UB), (4) on fitball (FB) and (5) on a Bosu® (BB). A total of 30 male participants (15 trained and 15 untrained) were evaluated for mean propulsive speed (MPS), maximum speed (MS), and power (PW) with different types of external load: a low load (40% of 1RM), medium load (60% of 1RM), and high load (80% of 1RM) in each condition. Variables were measured with an inertial dynamometer. (III) The best data were evidenced with SB, followed by AB (3–12%), UB (4–11%), FB (7–19%), and BB (14–23%). There were no differences between groups and loads (p > 0.05) except in the case of MS with 60% 1RM, where trained participants obtained 4% better data (p < 0.05). (IV) Executions with implements and equipment such as fitball and Bosu® do not seem to be the most recommended when the objective is to improve power or execution speed. However, situations where the load is unstable (AB and UB) seem to be a good alternative to improve stabilization work without high performance. Furthermore, experience does not seem to be a determining factor.
8K-UHD medical image remote transmission with low latency encoding and decoding

Currently, the need for telemedicine is increasing all over the world. At the same time, the resolution of various medical images has become higher than before, and resolution of surgical endoscopes in particular have reached 8K Ultra-High-Definition (UHD). We conducted demonstration experiments of 8K-UHD medical image remote transmission with low-latency encoding and decoding between two sites (Tokushima Prefectural Central Hospital and Tokushima Prefectural Miyoshi Hospital) 68km apart. The two sites were connected by a 10-Gbps cable TV network, and on the transmitting side (Tokushima Prefectural Miyoshi Hospital), 8K-UHD endoscope image was compressed from 48 Gbps to 300 Mbps for the local cable TV network by ELL 8K HEVC Encoder. On the receiving side, the compressed image was decoded in real time into 8K-UHD uncompressed 48-Gbps image by ELL 8K HEVC Decoder and displayed on a 70-inch 8K-UHD monitor. The latency between the two sites (from 8K-UHD camera to 8K-UHD monitor) was shortened to about 0.15 second, and we and hospital doctors were able to have a two-way conversation on the 4K video conference system (Vidyo) while watching 8K-UHD medical image without any discomfort. In the future, we will improve latency not only in 8K-UHD encoders/decoders but also in peripheral systems such as various interface conversions on the system and monitors.
A Test Case for the Organic Refractory Model of Interstellar Dust

The organic refractory model of interstellar dust postulates that the grains primarily responsible for visual extinction consist of silicate cores coated with organic refractory matter (ORM) supposed to form by photochemical processing of ice mantles. We identify the line of sight to the early-type star Elias 25, in the ρ Oph dark cloud, as a test for local production of ORM in an environment where mantled grains are exposed to a substantial ultraviolet radiation field. Infrared spectra of Elias 25 in the 2.4-4.0 μm region were used to examine the 3 μm ice profile and to search for the C–H bond absorption feature near 3.4 μm that occurs in laboratory-synthesized ORM. We find that the ice feature in Elias 25 has an unusually deep 3.1-3.7 μm wing, but no detectable 3.4 μm feature is present in the wing profile. An upper limit on the τ3.4/AV ratio is set that is a factor of 4 lower than that determined from the feature detected in the diffuse interstellar medium toward Cygnus OB2 No. 12. Our results are consistent with other evidence indicating that the carrier of the 3.4 μm feature is destroyed, rather than produced, inside dense clouds.
Optimizing multi-response surface problems: How to use multi-objective optimization techniques

A common problem encountered in product or process design is the selection of optimal parameter levels that involves the simultaneous consideration of multiple response characteristics, called a multi-response surface problem. Notwithstanding the importance of multi-response surface problems in practice, the development of an optimization scheme has received little attention. In this paper, we note that Multi-Response surface Optimization (MRO) can be viewed as a Multi-Objective Optimization (MOO) and that various techniques developed in MOO can be successfully utilized to deal with MRO problems. We also show that some of the existing desirability function approaches can, in fact, be characterized as special forms of MOO. We then demonstrate some MOO principles and methods in order to illustrate how these approaches can be employed to obtain more desirable solutions to MRO problems.
Advanced Study of Drought-Responsive Protein Pathways in Plants

Drought, the most significant environmental stressor, severely limits plant growth and development and significantly reduces crop production. Drought stress responses vary among plants, allowing them to withstand and survive adverse conditions. Plants resist drought by maintaining signaling pathways, such as the abscisic acid pathway, and activating unusual proteins, such as dehydrins. This study aims to investigate signaling pathways and the biological structures and activities of proteins involved in these processes. We also look into the occurrence of crosstalk across multiple signaling pathways and what it means for agricultural plant enhancement. By incorporating the most common components across all abiotic stress situations, this review provides insight into the evolution of drought stress tolerance in agricultural plants. This review could be helpful for crop drought stress researchers.
Audio description and interpreting training: a comparison of assessment criteria from the perspective of learners

ABSTRACT In recent years, researchers have noticed similarities between audio description (AD) and interpreting in training and quality assessment. Drawing on an AD training programme for interpreting students at a university in Hong Kong, this study explored the similarities and differences between AD and interpreting in terms of quality assessment and learner perception. Macrocriteria and microcriteria in AD and interpreting training were compared. It was found that AD and interpreting shared three macrocriteria: accuracy, language, and delivery. Meanwhile, a number of microcriteria and a macrocriterion were identified as exclusive either to interpreting or AD. The differences may be partly explained by the interlingual nature of interpreting, the intersemiotic nature of AD, and the relevant training arrangements. A survey was also conducted among 42 students to investigate learners’ perceptions of assessment criteria in AD and interpreting. The results show that the students identified some criteria as more difficult to achieve separately in AD and in interpreting, and they ranked some criteria as more important in AD and others as more important in interpreting. The findings of this study may help trainers better understand the needs of learners and develop more diverse and refined approaches to AD and interpreting training.