Miracle-dz/UniFAR-FTUs huggingface dataset:
Shoulder pain after stroke: prevalence, contributing factors and consequences in daily life

Post stroke shoulder pain, PSSP, is a common type of pain after stroke, but still further knowledge of this condition is needed. An increased knowledge of prevalence, contributing factors and impact on the individual’s life could enhance the possibility to find more effective treatments and therefore more studies are needed. The overall aim of this thesis was to evaluate PSSP with a special focus on prevalence, contributing factors and consequences in daily life. In an unselected stroke population of 327 individuals, the prevalence of PSSP was 22% four months post stroke. Predictors of PSSP (paper I) were shown to be severely affected arm motor function and severe impairments according to the National Institutes of Health Stroke Scale, (NIHSS). About 70% of the individuals with impaired sensorimotor function at stroke onset and PSSP at four months had still pain one year later. Predictors for long-lasting PSSP were left-sided hemiparesis, pain frequency and decreased passive shoulder abduction (paper II). In a group of 49 individuals with mild to moderate sensorimotor impairments post stroke (24 with and 25 without PSSP) and 11 healthy controls, somatosensory abnormalities were assessed with thermal and mechanical thresholds using the Quantitative Sensory Testing (QST) method. No significant difference in QST measurements were found between the groups with and without PSSP, but both stroke groups had generally higher thermal thresholds and more extreme low or high mechanical thresholds than the healthy controls (paper III). The association between PSSP, sensorimotor function, ability to perform daily hand activities, perceived participation and life satisfaction were evaluated in 24 individuals with and 25 individuals without PSSP, all with mild to moderate sensorimotor impairments. PSSP was associated with reduced motor function, but the PSSP had a weak association with daily hand activities, perceived participation and life satisfaction (paper IV). In conclusion, this thesis has shown that PSSP is common in individuals with decreased upper extremity motor function. Left-sided hemiparesis, pain frequency and decreased passive shoulder abduction seem to predict long-lasting PSSP. In individuals with mild to moderate upper extremity paresis, somatosensory impairments seem to have only a small impact on the pain and the PSSP appears to have a small impact on their life situation.
Polylactic acid: synthesis and biomedical applications

Social and economic development has driven considerable scientific and engineering efforts on the discovery, development and utilization of polymers. Polylactic acid (PLA) is one of the most promising biopolymers as it can be produced from nontoxic renewable feedstock. PLA has emerged as an important polymeric material for biomedical applications on account of its properties such as biocompatibility, biodegradability, mechanical strength and process ability. Lactic acid (LA) can be obtained by fermentation of sugars derived from renewable resources such as corn and sugarcane. PLA is thus an eco‐friendly nontoxic polymer with features that permit use in the human body. Although PLA has a wide spectrum of applications, there are certain limitations such as slow degradation rate, hydrophobicity and low impact toughness associated with its use. Blending PLA with other polymers offers convenient options to improve associated properties or to generate novel PLA polymers/blends for target applications. A variety of PLA blends have been explored for various biomedical applications such as drug delivery, implants, sutures and tissue engineering. PLA and their copolymers are becoming widely used in tissue engineering for function restoration of impaired tissues due to their excellent biocompatibility and mechanical properties. The relationship between PLA material properties, manufacturing processes and development of products with desirable characteristics is described in this article. LA production, PLA synthesis and their applications in the biomedical field are also discussed.
Two Outbreaks of Trichinellosis Linked to Consumption of Walrus Meat — Alaska, 2016–2017

During 1975-2012, CDC surveillance identified 1,680 trichinellosis cases in the United States with implicated food items; among these cases, 1,219 were attributed to consumption of raw or pork products, and 461 were attributed to nonpork products. Although trichinellosis in the United States has historically been associated with consumption of pork, multiple nonporcine species of wild game also are competent hosts for Trichinella spp. and have been collectively implicated in the majority of trichinellosis cases since the late 1990s (1-4) (Figure 1). During July 2016-May 2017, the Alaska Division of Public Health (ADPH) investigated two outbreaks of trichinellosis in the Norton Sound region associated with consumption of raw or undercooked walrus (Odobenus rosmarus) meat; five cases were identified in each of the two outbreaks. These were the first multiple-case outbreaks of walrus-associated trichinellosis in Alaska since 1992 (Figure 2). Health care providers should inquire about consumption of commercially prepared and personally harvested meats when evaluating suspected trichinellosis cases, especially in areas where consumption of wild game is commonplace.
1 In Vitro Cytochrome P 450 46 A 1 ( CYP 46 A 1 ) Activation by Neuroactive Compounds

Cytochrome P450 46A1 (CYP46A1, cholesterol 24-hydroxylase) is the enzyme responsible for the majority of cholesterol elimination from the brain. Previously, we found that the anti-HIV drug efavirenz (EFV) can pharmacologically activate CYP46A1 in mice. Herein, we investigated whether CYP46A1 could also be activated by endogenous compounds, including major neurotransmitters. In vitro experiments with purified recombinant CYP46A1 indicated that CYP46A1 is activated by L-glutamate (LGlu), L-aspartate, g-aminobutyric acid, and acetylcholine, with L-Glu eliciting the highest increase (3-fold) in CYP46A1-mediated cholesterol 24-hydroxylation. We also found that L-Glu and other activating neurotransmitters bind to the same site on the CYP46A1 surface, which differs from the EFVbinding site. The other principal differences between EFV and L-Glu in CYP46A1 activation include an apparent lack of L-Glu binding to the P450 active site and different pathways of signal transduction from the allosteric site to the active site. EFV and L-Glu similarly increased the CYP46A1 kcat, the rate of the “fast” phase of the enzyme reduction by the redox partner NADPH-cytochrome P450 oxidoreductase, and the amount of P450 reduced. Spectral titrations with cholesterol, in the presence of EFV or L-Glu, suggest that water displacement from the heme iron can be affected in activator-bound CYP46A1. Moreover, EFV and L-Glu synergistically activated CYP46A1. Collectively, our in vitro data, along with those from previous cell culture and in vivo studies by others, suggest that L-Glu-induced CYP46A1 activation is of physiological relevance.
Isogeometric Analysis

We present an introduction to Isogeometric Analysis, a new methodology for solving partial differential equations (PDEs) based on a synthesis of Computer Aided Design (CAD) and Finite Element Analysis (FEA) technologies. A prime motivation for the development of Isogeometric Analysis is to simplify the process of building detailed analysis models for complex engineering systems from CAD representations, a major bottleneck in the overall engineering process. However, we also show that Isogeometric Analysis is a powerful methodology for providing more accurate solutions of PDEs, and we summarize recently obtained mathematical results and describe open problems. Mathematics Subject Classification (2010). Primary 65N30; Secondary 65D07.
Potential Role of Nuclear Factor κB and Reactive Oxygen Species in cAMP and Cytokine Regulation of Surfactant Protein-A Gene Expression in Lung Type II Cells

The human surfactant protein-A2 (hSP-A2) gene is developmentally regulated, expressed in type II pneumonocytes, and induced by cAMP. cAMP induction of hSP-A2 expression is O2 dependent and mediated by increased phosphorylation, DNA binding, and transcriptional activation of thyroid transcription factor-1 (TTF-1). The TTF-1-binding element (TBE) at −175 bp contains a reverse-oriented nuclear factor-κB (NF-κB) binding site. IL-1 increased SP-A expression in lung type II cells and had additive stimulatory effects with cAMP. Nuclear extracts from cAMP- or IL-1-treated type II cells manifested increased binding to NF-κB consensus and TBE probes; cAMP and IL-1 had additive effects. Competitive and antibody supershift EMSA revealed that NF-κB and TTF-1 interact with TBE. IL-1 treatment of type II cells caused rapid (1 h) increases in nuclear levels of NF-κB (p50 and p65) and in binding to NF-κB and TBE probes; nuclear levels of TTF-1 were unaffected. Bt2cAMP increased binding to NF-κB and TBE probes more slowly;.
Deep-Water Carbonate Environments

The need to expand our search for energy resources into deeper marine environments makes a volume devoted entirely to deep-water carbonates most timely. It has become increasingly important to better understand deep marine environments and their transitions to shoal water settings. Of importance are the processes operating in deep-water settings and the magnitude and periodicity of these processes especially as they affect the geometry, textural character, and the overall lithologic and biologic patterns of the sediment. This volume represents contributions from researchers who have diverse perspectives. Their papers include new data on deep-water carbonate environments ranging in age from Cambrian to the present. The geologic settings of these studies are also quite varied and include modern and ancient deep open oceans, continental slopes and shelves and continental-interior basins. This volume was derived from a symposium held in Dallas, Texas, on April 8, 1975 at the joint meeting of AAPG and SEPM.
Assessment of Nurse Engagement

Organizations with high employee engagement reap the benefits of higher employee retention and improved customer satisfaction. Studies find that engaged workers are in the minority. Among healthcare workers, nurses are found to be the least engaged. The association of the registered nurse (RN) at the bedside with improved patient outcomes has been documented by many. Today, the goal of providing safe, high quality and efficient patient care and an exceptional patient experience are benchmark measures for patient care delivery. Since nurses are essential to optimal patient outcomes, it is important to understand what motivates them. Career advancement programs (CAPs) are one method of addressing the challenge of creating engagement. The purpose of this scholarly project is to determine if participation in a professional career advancement program for RNs improves nurse engagement and has an impact on patient outcomes. The study will survey RNs in a tertiary care academic center in the southwestern United States who are enrolled in a career advancement program. The results of this project demonstrated that participation in a professional career advancement program for RNs does not improve nurse engagement, and extraneous variables must be considered. The potential exists for employers to identify those variables that impact nurse engagement. This study did find, however, that there is a positive association between improved patient outcomes and participation in the career advancement program. career advancement , career ladder , staff
Journal of Intelligent and Robotic Systems Evaluation of Three Vision Based Object Perception Methods for a Mobile Robot

This paper addresses object perception applied to mobile robotics. Being able to perceive semantically meaningful objects in unstructured environments is a key capability in order to make robots suitable to perform high-level tasks in home environments. However, finding a solution for this task is daunting: it requires the ability to handle the variability in image formation in a moving camera with tight time constraints. The paper brings to attention some of the issues with applying three state of the art object recognition and detection methods in a mobile robotics scenario, and proposes methods to deal with windowing/segmentation. Thus, this work aims at evaluating the state-of-the-art in object perception in an attempt to develop a lightweight solution for mobile robotics use/research in typical indoor settings. Powered by Editorial Manager® and Preprint Manager® from Aries Systems Corporation Journal of Intelligent & Robotic Systems manuscript No. (will be inserted by the editor) Evaluation of Three Vision Based Object Perception Methods for a Mobile Robot Arnau Ramisa · David Aldavert · Shrihari Vasudevan · Ricardo Toledo · Ramon Lopez de Mantaras Received: date / Accepted: date Abstract This paper addresses object perception applied to mobile robotics. Being able to perceive semantically meaningful objects in unstructured environments is a key capability in order to make robots suitable to perform highlevel tasks in home environments. However, finding a solution for this task is daunting: it requires the ability to handle the variability in image formation in a moving camera with tight time constraints. The paper brings to attention some of the issues with applying three state of the art object recognition and detection methods in a mobile robotics scenario, and proposes methods to deal with windowing/segmentation. Thus, this work aims at evaluating the state-of-the-art in object perception in an attempt to develop a lightweight solution for mobile robotics use/research in typical indoor settings.This paper addresses object perception applied to mobile robotics. Being able to perceive semantically meaningful objects in unstructured environments is a key capability in order to make robots suitable to perform highlevel tasks in home environments. However, finding a solution for this task is daunting: it requires the ability to handle the variability in image formation in a moving camera with tight time constraints. The paper brings to attention some of the issues with applying three state of the art object recognition and detection methods in a mobile robotics scenario, and proposes methods to deal with windowing/segmentation. Thus, this work aims at evaluating the state-of-the-art in object perception in an attempt to develop a lightweight solution for mobile robotics use/research in typical indoor settings.
Biomedical texts of endometrial cancer-related genes

[摘要]目的:寻找与子宫内膜癌发生、发展相关的关键基因。 方法:从医学信息检索平台 Coremine Medical 中筛选出与子宫内 膜癌关系最为密切的几种关键基因,再利用生物医学文本挖掘工具 Chilibot 对从 PubMed 中获取的相关文献摘要进行分析,深 入探究关键基因与子宫内膜癌之间的相互关系,并通过 UALCAN 在线工具分析关键基因的表达水平和甲基化水平。 结果:确 定了与子宫内膜癌关系最密切的 5 种关键基因。 在子宫内膜癌组织中,MLH1 基因的甲基化水平比正常子宫内膜组织的甲基 化水平要高(P<0. 001),MLH1 基因甲基化的发生导致了 DNA 错配修复基因的突变,从而促进了子宫内膜癌的发生。 与正常 子宫内膜组织相比,MSH2 基因和 PMS2 基因在子宫内膜癌组织中表达量较高(P<0. 001),MSH6 基因和抑癌基因 PTEN 在子 宫内膜癌组织中的表达均比正常子宫内膜组织表达要低(P<0. 001)。 错配修复基因 MLH1、MSH2、MSH6 以及 PMS2 的突变, 促进了相应修复蛋白的缺失,进而导致了子宫内膜癌的发生、发展。 结论:错配修复基因 MLH1、MSH2、MSH6、PMS2 以及抑癌 基因 PTEN 是子宫内膜癌发生、发展的关键基因。 [关键词]生物医学文本挖掘;子宫内膜癌;关键基因;Coremine Medical;Chilibot [中图分类号]R737. 33;TP311. 13摇 摇 摇 摇 [文献标志码]A摇 摇 摇 摇 摇 [文章编号]1671-3982(2019)06-0001-08
Indigenous knowledge in a post‐apology era: Steps toward healing and bridge building

EDITOR'S SUMMARY An important aspect of ASIS&T's international outreach is service to indigenous populations, a need that has received greater recognition since Canadian Prime Minister Stephen Harper's public apology in 2008 for past disruption of Native families. The emerging field of indigenous librarianship can contribute significantly to the process of reconciliation in Canada and other countries with similar colonial legacies. Indigenous librarianship requires reconsidering the organization, classification and representation of library materials from a perspective free of culture- and language-based assumptions. Key themes in indigenous librarianship include removing barriers to access, providing culturally relevant materials and services and departing from widely used knowledge organization systems such as the Dewey Decimal System to create classifications that reflect the Native worldview and epistemology. Successful examples include Australia's Pathways thesaurus project, the Māori Subject Headings from Aotearoa/New Zealand and the British Columbia First Nations Names Authority. Increased involvement by Indigenous people in information studies will enhance accurate representation of their cultures.
Super Resolution based In-Painting for Digital Images

The purpose of this review paper is to show how an unwanted object is removed from the existing digital image, increase the resolution and repair the image etc. The proposed system will use two algorithms- 1. In-painting algorithm and 2. Super Resolution algorithm. In-painting is the process of reconstructing lost or deteriorated part of images based on background information. Image in-painting fills the missing or damaged region in an image, utilizing information of its neighboring region. In-painting algorithm has numerous applications. Such as, it can be used for restoration of old films and object removal in digital photographs. Super resolution reconstruction algorithm produces high resolution image from sequence of low resolution images. The main aim of super resolution is to improve visual quality of available low resolution images. Hence, the proposed system can be used for reconstructing the missing portion of images in order to make it more legible, restore its unity and super resolve the quality of the image.
The Paganica Fault and Surface Coseismic Ruptures Caused by the 6 April 2009 Earthquake (L'Aquila, Central Italy)

On 6 April 2009, at 01:32 GMT, an Mw 6.3 seismic event hit the central Apennines, severely damaging the town of L'Aquila and dozens of neighboring villages and resulting in approximately 300 casualties (Istituto Nazionale di Geofisica e Vulcanologia, http://www.ingv.it; MedNet, http://mednet.rm.ingv.it/procedure/events/QRCMT/090406_013322/qrcmt.html). This earthquake was the strongest in central Italy since the devastating 1915 Fucino event ( Mw 7.0). The INGV national seismic network located the hypocenter 5 km southwest of L'Aquila, 8–9 km deep. Based on this information and on the seismotectonic framework of the region, earthquake geologists traveled to the field to identify possible surface faulting (Emergeo Working Group 2009a, 2009b). The most convincing evidence of primary surface rupture is along the Paganica fault, the geometry of which is consistent with seismological, synthetic aperture radar (SAR) and GPS data. Investigation of other known normal faults of the area, i.e. , the Mt. Pettino, Mt. San Franco, and Mt. Stabiata normal faults suggested that these structures were not activated during the April 6 shock (Emergeo Working Group 2009a, 2009b). In this report, we first describe the seismotectonic framework of the area, and then we present the field information that supports the occurrence of surficial displacement on the Paganica fault. The shock of 6 April 2009 occurred in a region that has been struck by past earthquakes (CPTI Working Group 2004; Figure 1) and is in an Apennine sector that contains a complex array of active normal faults ( e.g. , Barchi et al. 2000; Galadini and Galli 2000; Boncio et al. 2004; Roberts and Michetti 2004). In the central Apennines, active faulting and earthquakes result from the ongoing extensional tectonics. The strongest earthquakes in the CPTI04 seismic catalog (CPTI Working Group 2004) occurred on 9 September 1349 ( Mw 6.5) and 2 February …
Pattern of oestrogen, progesterone and Her2neu receptors expression in a heterogeneous carcinoma of the breast in a lactating woman

Oestrogen-progestrone-Her2neu receptor status was studied in various loci/foci of heterogeneous carcinoma of the breast and its metastatic secretory component in the lymph node in a lactating woman. All the carcinoma variants were negative for the trio markers except tumour components evolved to secretory or lactating carcinoma, which showed focal positivity. Findings showed that oestrogenic receptors, progesterone receptors and Her2neu negative primitive carcinoma in a heterogenous breast cancer may evolve into oestrogen receptor, progesterone receptor and Her2neu positive secretory/lactating carcinoma alongside other receptor negative carcinoma variants. Focal marker positivity/negativity underlined the fact that a diagnostic/prognostic marker status report may account for the tumour area included in the section/sample only. Study of the immune marker expression/status in various loci may help identification of the components, morphogenesis and dynamics of heterogeneous carcinoma of the breast.
China clay industrial waste in concrete

This paper deals with the performance of China Clay industrial Waste (CCW) as partial replacement of fine aggregate in concrete. The performance of CCW used in concrete has been ascertained by comparing its compressive strength, split tensile strength, flexural strength, acid resistance & heat resistance with conventional concrete. Test results show that natural sand can be effectively replaced with up to 30% of CCW in concrete without changing its durability.
Pheno-Morphological Traits of Mungbean as Influenced by Phosphorous and Tillage under Irrigated and Un-irrigated Conditions

Phosphorus (P) deficiency is one of the major growth limiting factors throughout the world and especially in Pakistan. Field experiment was conducted to study the effect of P levels and tillage depths (cm) on phenology and growth of mungbean (Vigna radiate L. Wilczek, cv. NM-54), under irrigated and un-irrigated conditions. Two separate fields were used for irrigated and un-irrigated conditions at New Developmental Farm of The University of Agriculture Peshawar, Pakistan during summer 2012.The experiment in each field was laid out in randomized complete block design with split plot arrangement having three replications. Three tillage depths (45, 30 and 15 cm) were allotted to main plots, while P levels (0, 30, 60 and 90 kg P ha -1 ) were allotted to sub plots. The results reve aled that P application at the two higher rates (60 and 90 kg P ha -1 ) hastened days to flowering (46 days each) and pod formation (55 &54 days, respectively), increased plant height (73 & 68 cm, respectively), number of leaves plant -1 (19 each) and straw yield (1859& 1992 kg ha -1 , respectively). Plots tilled 45 cm deep delayed flowering (48 days) and pod formation (57 days). However, tillage depths had no significant effect on other growth parameters and straw yield. Irrigated plots took more days to flowering (48 days) and pod formation (57 days), produced taller plants (69 cm), more number of leaves plant -1 (18) and straw yield (1889 kg ha -1 ) when compared with un-irrigated plots. In the light of these results, we concluded that P application at the rate 60 kg P ha -1 was considered the most suitable P rate for improving mungbean productivity under irrigated and un-irrigated condition. Deep tillage (45 cm) was considered more beneficial in terms of higher mungbean productivity under un-irrigated condition, while shallow tillage (15 cm) was better under irrigated condition in the study area.