Miracle-dz/UniFAR-FTUs huggingface dataset:
Hosting Swinging Restraining Controller For Flexible Approximation

This paper handles the style of an adaptive power oscillation damping controller for any static synchronous compensator outfitted with energy storage. The suggested technique is good at growing the damping from the system in the wavelengths of great interest, and in the situation of system parameter uncertainties and also at various connection points from the compensator. Therefore, the E-STATCOM could be modeled like a controlled ideal current source, as portrayed within the equivalent circuit, for analysis purpose. First, the research into the impact of active and reactive power injection in to the power system is going to be transported out utilizing a simple two-machine system model. This really is accomplished utilizing a signal estimation technique with different modified recursive least square formula, which enables a quick, selective, and adaptive estimation from the low-frequency electromechanical oscillations from in your area measured signals during power system disturbances. A control strategy that maximizes active and reactive power injection at various connection points from the STATCOM is going to be derived while using simplified model. Small-signal research into the dynamic performance from the suggested control strategy is going to be transported out. The potency of the suggested control approach to provide power oscillation damping regardless of the bond reason for the unit as well as in the existence of system parameter uncertainties is going to be verified through simulation and experimental results.
Follicular free fatty acid metabolic signatures and their effects on oocyte competence in non-obese PCOS patients.

Polycystic ovary syndrome (PCOS) is a heterogeneous disease characterized by various endocrine/metabolic disorders and impaired reproductive potential. Alterations in oocyte competence are considered potentially causative factor for infertility in PCOS women and analyzing the composition of follicular fluid in these patients may help to identify which changes have the potential to alter oocyte quality. In this study, free fatty acid metabolic signatures in follicular fluid were performed to identify changes that may impact oocyte competence in non-obese PCOS women. Sixty-four non-obese women (32 with PCOS and 32 age- and BMI-matched controls) undergoing in vitro fertilization were recruited. Embryo quality was morphologically assessed. Free fatty acid metabolic profiling in follicular fluid was performed using gas/liquid chromatography-mass spectrometry. Principal component analysis and orthogonal partial least squares-discriminant analysis models were further constructed. Nine free fatty acids and twenty-four eicosanoids were identified and several eicosanoids synthesized by the cyclooxygenase pathway were significantly elevated in PCOS patients compared to controls. The combination of PGE2, PGF2α, PGJ2, and TXB2 had an area under the curve of 0.867 (0.775-0.960) for PCOS discrimination. Furthermore, follicular fluid levels of PGE2 and PGJ2 were negatively correlated with high-quality embryo rate in PCOS patients (P < 0.05). Metabolomic analysis revealed that follicular fluid lipidomic profiles undergo changes in non-obese PCOS women, which suggest that identifying changes in important metabolic signatures may give us a better understanding of the pathogenesis of PCOS. Furthermore, elevated PGE2 and PGJ2 concentrations may contribute to impaired oocyte competence in non-obese PCOS patients.
FoQDE2-dependent milRNA promotes Fusarium oxysporum f. sp. cubense virulence by silencing a glycosyl hydrolase coding gene expression

MicroRNAs (miRNAs) are small non-coding RNAs that regulate protein-coding gene expression primarily found in plants and animals. Fungi produce microRNA-like RNAs (milRNAs) that are structurally similar to miRNAs and functionally important in various biological processes. The fungus Fusarium oxysporum f. sp. cubense (Foc) is the causal agent of Banana Fusarium vascular wilt that threatens global banana production. It remains uncharacterized about the biosynthesis and functions of milRNAs in Foc. In this study, we investigated the biological function of milRNAs contributing to Foc pathogenesis. Within 24 hours post infecting the host, the Argonaute coding gene FoQDE2, and two Dicer coding genes FoDCL1 and FoDCL2, all of which are involved in milRNA biosynthesis, were significantly induced. FoQDE2 deletion mutant exhibited decreased virulence, suggesting the involvement of milRNA biosynthesis in the Foc pathogenesis. By small RNA sequencing, we identified 364 small RNA-producing loci in the Foc genome, 25 of which were significantly down-regulated in the FoQDE2 deletion mutant, from which milR-87 was verified as a FoQDE2-depedent milRNA based on qRT-PCR and Northern blot analysis. Compared to the wild-type, the deletion mutant of milR-87 was significantly reduced in virulence, while overexpression of milR-87 enhanced disease severity, confirming that milR-87 is crucial for Foc virulence in the infection process. We furthermore identified FOIG_15013 (a glycosyl hydrolase-coding gene) as the direct target of milR-87 based on the expression of FOIG_15013-GFP fusion protein. The FOIG_15013 deletion mutant displayed similar phenotypes as the overexpression of milR-87, with a dramatic increase in the growth, conidiation and virulence. Transient expression of FOIG_15013 in Nicotiana benthamiana leaves activates the host defense responses. Collectively, this study documents the involvement of milRNAs in the manifestation of the devastating fungal disease in banana, and demonstrates the importance of milRNAs in the pathogenesis and other biological processes. Further analyses of the biosynthesis and expression regulation of fungal milRNAs may offer a novel strategy to combat devastating fungal diseases.
The coronary capillary bed and its role in blood flow and oxygen delivery: A review

The assumption that the coronary capillary blood flow is exclusively regulated by precapillary vessels is not supported by recent data. Rather, the complex coronary capillary bed has unique structural and geometric characteristics that invalidate many assumptions regarding red blood cell (RBC) transport, for example, data based on a single capillary or that increases in flow are the result of capillary recruitment. It is now recognized that all coronary capillaries are open and that their variations in flow are due to structural differences, local O2 demand and delivery, and variations in hematocrit. Recent data reveal that local mechanisms within the capillary bed regulate flow via signaling mechanisms involving RBC signaling and endothelial‐associated pericytes that contract and relax in response to humoral and neural signaling. The discovery that pericytes respond to vasoactive signals (e.g., nitric oxide, phenylephrine, and adenosine) underscores the role of these cells in regulating capillary diameter and consequently RBC flux and oxygen delivery. RBCs also affect blood flow by sensing PO2 and releasing nitric oxide to facilitate relaxation of pericytes and a consequential capillary dilation. New data indicate that these signaling mechanisms allow control of blood flow in specific coronary capillaries according to their oxygen requirements. In conclusion, mechanisms in the coronary capillary bed facilitate RBC density and transit time, hematocrit, blood flow and O2 delivery, factors that decrease capillary heterogeneity. These findings have important clinical implications for myocardial ischemia and infarction, as well as other vascular diseases.
The Value of Tracking Data on the Behavior of Patients Who Have Undergone Bariatric Surgery: Explorative Study

Background To maintain the benefits of a bariatric procedure, patients have to change their lifestyle permanently. This happens within a context of coresponsibilities of health care professionals and their social support system. However, most interventions are focused on the patient as an individual. In this explorative pilot study, behavioral, contextual, and experiential data were gathered to obtain insight on coresponsibility. Objective The aim of this study is to explore the use of trackers by patients who have undergone bariatric surgery in a data-enabled design approach. Methods Behavioral and contextual data on the households of patients who have undergone bariatric surgery were explored using a smartphone with an interactive user interface (UI), weight scale, activity bracelet, smart socket, accelerometer motion sensor, and event button to find examples of opportunities for future interventions. Results A total of 6 households were monitored. Approximately 483,000 data points were collected, and the participants engaged in 1483 conversations with the system. Examples were found using different combinations of data types, which provided the obesity team a better understanding of patient behaviors and their support system, such as a referral to a family coach instead of a dietician. Another finding regarding the partners was, for example, that the conversational UI system facilitated discussion about the support structure by asking for awareness. Conclusions An intelligent system using a combination of quantitative data gathered by data tracking products in the home environment and qualitative data gathered by app-enhanced short conversations, as well as face-to-face interviews, is useful for an improved understanding of coresponsibilities in the households of patients who have undergone bariatric surgery. The examples found in this explorative study so far encourage research in this field.
Information sharing practices during the COVID-19 pandemic: A case study about face masks

This article contributes an empirical analysis of information sharing practices on Twitter relating to the use of face masks in the context of COVID-19. Behavioural changes, such as the use of face masks, are often influenced by people’s knowledge and perceptions, which in turn can be affected by the information available to them. Face masks were not recommended for use by the UK public at the beginning of the COVID-19 pandemic. Due to developments in scientific understanding, the guidance changed and by the end of 2020 they were mandatory on public transport and in shops. This research examines tweets in this longitudinal context and, therefore, provides novel insights into the dynamics of crisis communication in an ongoing crisis event with emerging scientific evidence. Specifically, analysis of the content of tweets, external resources most frequently shared, and users sharing information are considered. The conclusions contribute to developing understanding of the digital information ecology and provide practical insights for crisis communicators. Firstly, the analysis shows changes in the frequency of tweets about the topic correspond with key guidance and policy changes. These are, therefore, points in time official channels of information need to utilise the public’s information seeking and sharing practices. Secondly, due to changes in face mask guidance and policy, the current literature on digital information ecology is insufficient for capturing the dynamic nature of a long-term ongoing crisis event. Challenges can arise due to the prolonged circulation of out-of-date information, i.e. not strategic misinformation, nor “mis”-information at all, which can have serious ramifications for crisis communication practitioners. Thirdly, the role of traditional media and other journalism/broadcasting platforms in shaping conversations is evident, as is the potential for scientific organisations’ and individual people’s Twitter user accounts. This plurality of contributors needs to be acknowledged and understood to inform crisis communication strategies.
Device-worn measures of sedentary time and physical activity in South Asian adults at high risk for type 2 diabetes in Metro-Vancouver, Canada

Background South Asians have high incidence of chronic disease. Physical activity (PA) and sedentary time are modifiable risk factors for chronic disease but their assessment in South Asians has been primarily based on self-report. This study presents directly-measured PA and sedentary time in South Asian adults in Canada. Methods A subset of 100 South Asian participants from a larger study who were identified at being at a higher risk for type 2 diabetes wore Actical accelerometers for 7 days. Anthropometric measures were taken and socio-demographic factors including age, income, education level, years since immigration, presence of children under the age of 12 years in the household and employment status were self-reported. Results Ninety-one participants (mean age 65.6 years) provided valid accelerometer data. Participants accumulated mean 673.5 (95% CI: 656.6, 691.0) min/day sedentary time, 130.5 (95% CI: 117.3, 145.3) min/day light PA (LPA) and 2.3 (95% CI: 1.3, 4.2) min/day moderate-to-vigorous PA (MVPA). For sedentary time and LPA, sex and BMI explained 51% of variability. For MVPA, BMI, season of assessment and employment status explained 23% variability with those who were employed accumulating significantly higher mean min/day of MVPA compared to those who were unemployed; (5.8, 95% CI: 1.5, 21.7) vs (1.5, 95% CI: 5.3, 20.0) respectively. Conclusion High sedentary time, and low MVPA indicates the need to focus health promotion efforts on shifting sedentary time into LPA while trying to increase MVPA. Future studies need to be based on larger, representative samples of South Asians.
Environmental aspects of rail vehicles with combustion engines

This paper covers the environmental issues related to the operation of rail vehicles. The evaluation of the environmental impact is based in most cases on a comparison of the current state of the internal combustion engine (its emissivity) with emission limit values of harmful exhaust components. These values relate to specific emission tests for engines or vehicles. For the national rail vehicles operating conditions these requirements take a slightly different form, as having a wide range of rolling stock markedly alters the environmental impact of these vehicles. Thus it becomes necessary to consider the issue of the method of evaluation of engine emissions in rail vehicles in terms of their actual operating conditions. Thus, efforts to assess the actual level of emissivity for rail vehicles and attempts to improve it are necessary and justified.
12th Korea Healthcare Congress 2021; 김치국부터 마시지 말라; The Time for Digital Health is Almost Here

We are now on the cusp of massive adoption of digital health technologies. Medicine is becoming an information science intertwined with technology and data science. This talk aims to describe the current state of digital transformation in healthcare, to identify reasons for enthusiasm and caution, and to provide a framework for thinking about what is necessary for hospitals and health systems to be confident about incorporating these innovations into practice. I have three key recommendations. First, we should buy results, not claims. Those in positions that influence decisions about endorsing or purchasing digital products designed to improve care or outcomes ought to buy results, not claims or intermediate results. Moreover, although analytic validity and clinical validity are important, they sometimes do not reflect the impact of a product in its entirety. Ultimately, we need to know whether patients benefit. Second, we should insist on transparency. The performance of a product cannot be a secret. The basis on which developers make claims about their products should be open to all, including patients. Better yet, data on which experts reach a conclusion should be shared, just as many companies share research data on drugs and devices. Third, we should be aware of unintended adverse consequences. We should evaluate every intervention for unintended adverse consequences. Changes to systems, with all good intentions, can always go awry. In conclusion, insistence on good and evolving evidence is the best way to arrive at our destination: the use of innovations to improve outcomes.
Assessing the benefits of installing energy storage in a household equipped with photovoltaic panels

This paper evaluates the technical and financial impact of installing energy storage in a house equipped with Photovoltaic (PV) panels subject to the Feed-In Tariff (FIT). An additional benefit of installing energy storage is the possibility to purchase electricity off-peak (overnight) at a cheap rate and replace consumption during day/peak time and for this reason, the Economy7 tariff is considered. The studies carried out are using real data of PV generation and household consumption continuously recorded over a week for each of the four seasons, from a UK installation. A functional model of the battery system is implemented that includes voltage dependency versus state of charge and maximum charging and discharging currents, that account for the limitations of the amount of charge - size dependant and current that can reflect the power capability of the battery to preserve high conversion efficiencies and lifetime. As initial investigations point to a rather large battery system to maximize the synergy between PV and energy storage, the paper investigates how the performance indicators vary with the battery size. It is found that there may be a critical battery size up to which the peak rate consumption and the PV energy export decrease more rapidly. Above this critical point which in this study lies at around 25-30% of the battery size that would allow full local use of PV energy generated, the impact of increasing the battery size reduces, therefore the return of investment as a percentage decreases.
Relationship between tumor mutational burden, gene mutation status, and clinical characteristics in 340 cases of lung adenocarcinoma

Tumor mutational burden (TMB) is an emerging predictive marker of response to immune checkpoint inhibitor therapies. We evaluated the correlation between clinical indicators and high‐throughput sequencing results and TMB in lung adenocarcinoma patients, with the aim of finding simpler and more economical factors as surrogate markers for TMB.
Pain Management Strategies for Minimally Invasive Cardiothoracic Surgery

Pain management after minimally invasive cardiothoracic surgery (MICTS) continues to be a significant challenge, and the optimal analgesic strategy has yet to be defined. Pain after traditional thoracotomy is generally severe and is attributed to a combination of injury to the ribs, pleura, intercostal nerves, costovertebral joints, and muscles. Beyond immense patient dissatisfaction, poorly controlled pain can lead to splinting, ineffective coughing, hypoxia, atelectasis, and ultimately, respiratory failure and pneumonia. Furthermore, poor pain control delays early extubation, a metric that reduces length of hospital stay as well as overall morbidity and mortality. In addition, poorly controlled pain after thoracotomy can lead to incapacitating chronic pain, termed post-thoracotomy pain syndrome (PTPS), defined as persistent or recurrent pain at the thoracotomy incision at least 2 months after the surgical procedure. In most cases the pain is mild, but in a subset of patients, the pain is severe. PTPS is common after traditional thoracotomy, with a prevalence of approximately 50%. 3,7–10 MICTS inflicts less tissue trauma and consequently a smaller inflammatory response compared with open surgery. This leads to a faster recovery, less acute pain postoperatively, and a lower incidence of chronic pain. Nonetheless, patients who undergo MICTS still frequently experience severe postoperative pain,13–16 and the prevalence of PTPS after video-assisted thoracoscopic surgery (VATS) is still approximately 30%. Multimodal pain management strategies have been championed as part of fast-tracked enhanced recovery after surgery (ERAS) programs to reduce the postoperative morbidity and mortality associated with poorly controlled pain and to address the multifactorial pathophysiology of thoracotomy pain. ERAS uses evidence-based, multimodal perioperative care pathways to improve perioperative patient experience and outcomes.18–23 Opioids were traditionally the cornerstone of pain management, but all contemporary ERAS programs recommend minimizing their use, due to the numerous side effects, as well as the ongoing opioid crisis that led to 9.7 million people misusing prescription pain relievers and more than 48,000 deaths due to synthetic opioids (excluding methadone) in 2019.24–27 These programs instead advocate the implementation of a combination of locoregional (Fig. 1) and opioid-sparing systemic analgesia, which synergistically targets multiple sites along the pain pathway. Despite these newer recommendations, data supporting a unified analgesic strategy are limited, and their implementation into clinical practice remains unstandardized.28–32 Herein, we provide a brief overview of popular pain management strategies for MICTS that can increase patient satisfaction and reduce postoperative morbidity and mortality.
P38 initiates degeneration of midbrain GABAergic and glutamatergic neurons in diabetes models

Diabetes mellitus may cause tau protein hyperphosphorylation and neurodegeneration, but the exact mechanism by which diabetic conditions induce tau pathology remains unclear. Tau protein hyperphosphorylation is considered a major pathological hallmark of neurodegeneration and can be triggered by diabetes. Various tau‐directed kinases, including P38, can be activated upon diabetic stress and induce tau hyperphosphorylation. Despite extensive research efforts, the exact tau specie(s) and kinases driving neurodegeneration in diabetes mellitus have not been clearly elucidated. We herein employed different techniques to determine the exact molecular mechanism of tau pathology triggered by diabetes in in vivo and in vitro models. We showed that diabetes‐related stresses and glucose metabolism deficiency could induce cis P‐tau (an early driver of the tau pathology) accumulation in the midbrain and corpus callosum of the diabetic mice models and cells treated with 2‐deoxy‐D‐glucose, respectively. We found that the active phosphorylated level of P38 was increased in the treated cells and diabetic mice models. We observed that oxidative stress activated P38, which directly and indirectly drove tau pathology in the GABAergic and glutamatergic neurons of the midbrain of the diabetic mice after 96 h, which accumulated in the other neighboring brain areas after 2 months. Notably, P38 inhibition suppressed tau pathogenicity and risk‐taking behaviors in the animal models after 96 h. The data establish P38 as a central mediator of diabetes mellitus‐induced tau pathology. Our findings provide mechanistic insight into the consequences of this metabolic disorder on the nervous system.
Physics and applications of squid-inspired jetting

In the aquatic world jet propulsion is a highly successful locomotion method utilized by a variety of species. Among them cephalopods such as squids excel in their ability for high-speed swimming. This mechanism inspires the development of underwater locomotion techniques which are particularly useful in soft-bodied robots. In this overview we summarize existing studies on this topic, ranging from investigations on the underlying physics to the creation of mechanical systems utilizing this locomotion mode. Research directions that worth future investigation are also discussed.