Miracle-dz/UniFAR-FTUs huggingface dataset:
Aplicación De Recursos Fuzzy Logic Para La Asociación De Hoteles De Un Destino Turístico (Applying Fuzzy Logic Resources for Hotel Clustering within a Touristic Destination)

Spanish Abstract: Una de las principales problematicas en la conformacion de clusteres es la eleccion de sus integrantes, lo anterior por la desconfianza a no obtener los resultados deseados y si la perdida de su ventaja competitiva, la teoria menciona que mientras mas afines sean los integrantes de un cluster esta problematica disminuye, es por ello que en el presente documento realizamos una aplicacion de recursos proporcionados por la teoria de la logica difusa y la teoria de afinidades que nos garantiza la conformacion de agrupamientos de elementos afines, en el desarrollo de esta aplicacion se considero como variable de agrupacion a la competitividad de los hoteles dependiente de la gestion de sus recursos humanos, recursos tecnologicos, recursos de innovacion, recursos organizativos y recursos comerciales, lo anterior con fundamento en la teoria de recursos y capacidades. Los resultados presentan seis grupos de miembros muy relacionados que podrian realizar clusteres efectivos English Abstract: One of the main problems with creating clusters is the choice of elements. This occurs mainly because of a degree of uncertainty of failing to obtain desired results or the loss of competitive advantage. The theory sustains the higher the degree of similarity in environmental conditions and customer characteristics within the cluster members the lesser the uncertainty. As a result, this article provides an application of resources using the fuzzy logic technique of data mining and the similarity theory that will guarantee solving the problem of choosing the best members for the cluster. Within the development of this analysis we considered a cluster variable of hotel competitiveness based on: human resources management, technological resources, innovation resources, organizational resources and commercial resources. All these factors are based on the theory of resources and capabilities. The results provide six groups of highly intertwined members which could create effective clusters.
The regional differentiation of the demographic movements in the Republic of Macedonia

Abstract The Republic of Macedonia covers an area of 25,713 km² and according to data from the census conducted in 2002, it has a population of 2,022,547 inhabitants. In the past, the Republic of Macedonia was characterized by some significant demographic changes, including a decline in the average annual rate of population increase. The enhanced immigration movements and sudden decline in the rates of natural population increase have led to changes in distribution of the population and to a spatial differentiation in the population. The long period of transition in the country has been reflected in the spatial development of the country and its demographic processes and to relocation of the population. The different natural-geographical characteristics, unequal regional development potentials, unequal economic development, and demographic characteristics have led to changes in the demographic situation of certain regions. The regions that continually lose part of its population clearly differ from these regions that are characterized by an increased population which is leading to a greater concentration of people in certain location. Further decades with a declining birth rate, followed by a change in the values of population increase, together with migration movements, particularly from the rural and less developed economic regions, has resulted in a decline in the population. The different zones of depopulation and concentration in a simple way express the complex relationships in the population composition.
Maternal chronic hypertension in women veterans

Abstract Objective To describe the prevalence of maternal chronic hypertension (MCH), assess how frequently blood pressure is controlled before pregnancy among those with MCH, and explore management practices for antihypertensive medications (AHM) during the pre‐pregnancy and pregnancy periods. Data Sources, Study Setting, and Study Design We conducted a descriptive observational study using data abstracted from the Veterans Health Administration (VA) inclusive of approximately 11 million Veterans utilizing the VA in fiscal years 2010–2019. Data Collection/Extraction Methods Veterans aged 18–50 were included if they had a diagnosis of chronic hypertension before a documented pregnancy in the VA EMR. We identified chronic hypertension and pregnancy with diagnosis codes and defined uncontrolled blood pressure as ≥140/90 mm Hg on at least one measurement in the year before pregnancy. Sensitivity models were conducted for individuals with at least two blood pressure measurements in the year prior to pregnancy. Multivariable logistic regression explored the association of covariates with recommended and non‐recommended AHMs received 0–6 months before pregnancy and during pregnancy. Principal Findings In total, 8% (3767/46,178) of Veterans with a documented pregnancy in VA data had MCH. Among 2750 with MCH meeting inclusion criteria, 60% (n = 1626) had uncontrolled blood pressure on at least one BP reading and 31% (n = 846) had uncontrolled blood pressure on at least two BP readings in the year before pregnancy. For medications, 16% (n = 437) received a non‐recommended AHM during pregnancy. Chronic kidney disease (OR = 3.2; 1.6–6.4) and diabetes (OR = 2.3; 1.7–3.0) were most strongly associated with use of a non‐recommended AHM during pregnancy. Conclusions Interventions are needed to decrease the prevalence of MCH, improve preconception blood pressure control, and ensure optimal pharmacologic antihypertensive management among Veterans of childbearing potential.
Association between anxiety and elevated blood pressure in adolescent patients: a single-center cross-sectional study

Objective: Although anxiety is known to be associated with elevated blood pressure and hypertension in adults, this has not been studied in children. The aim of this study was to determine the association between anxiety and elevated blood pressures in adolescents. Methods: Adolescents, aged 12–18 years old, referred to the nephrology clinic were eligible to participate. Elevated blood pressure was defined as either SBP or DBP measurement above the 95th percentile for age, height, and sex. Participants were evaluated for anxiety using the validated Screen for Child Anxiety Related Disorders questionnaire filled independently by the child (SCARED-C) and parent (SCARED-P) evaluating the child. Results: Two hundred adolescents participated in this study. Thirty-one (53%) of SCARED-P-positive participants were found to have elevated blood pressure compared with 27 (19%) of SCARED-P negative, P 0.03. Twenty-five (43%) of SCARED-P positive had elevated DBP compared with 31 (28%) of SCARED-P negative (P 0.003). In SCARED-P positive, mean DBP (78.4 ± 9.9) was higher compared with SCARED-P negative (74.9 ± 9.2) (P 0.03). In a subgroup of adolescents (№ 130) not treated with blood pressure medications mean DBP was higher in both SCARED-P (79.0 ± 10.1) and SCARED-C (77.1 ± 10.4) positive groups compared with SCARED-P (73.6 ± 9.3) and SCARED-C (73 ± 8.9) negative, respectively. Conclusion: Our study demonstrates an association between anxiety and elevated DBP in adolescent children. Screening adolescents for anxiety should be a part of the routine evaluation of adolescent children.
LA INNOVACIÓN Y LAS CONDICIONES PARA DESARROLLAR EL ESPÍRITU EMPRENDEDOR

Resumen El proposito de esta investigacion es estudiar el fenomeno de los condicionantes de la relacion de la innovacion y el desarrollo del espiritu emprendedor. Uno de los pilares basicos del desarrollo del espiritu emprendedor es la educacion, fuente innovadora inagotable de mejora e innovacion. La economia del siglo XXI esta orientada al aprendizaje. La promocion del emprendedorismo envuelve un cambio cultural basado en la premisa de que las personas pueden mejorar su calidad de vida y de otros, tomando para si mismos la tarea de dirigir y definir su propio destino y construyedo los suyos propios. No se trata apenas de producir mas con menos costes, lo que se pretende, principalmente, es formentar el proceso innovador de la manera mas inteligente posible. En este contexto, las universidades adquieren una importancia vital. Ante esto, el espacio iberoamericano debe ser el escenario de colaboraciones para acciones conjuntas de la capacidad de generacion de conocimiento ya existente, constituye la dimension crucial de cualquier esfuerzo de desarrollo en paises como Brasil. Hoy en dia la participacion de la microempresa es considerada clave para el desarrollo de cualquier economia. Asi como la actitud emprendedora es considearada la puerta de entrada para la creaccion de empresas. Palabras clave: emprendimiento, microempresa, incubacion. Abstract The purpose of this research is to study the phenomenon of conditioning the relationship between innovation and development of entrepreneurship. One of the cornerstones of the development of entrepreneurship is education, innovative inexhaustible source of improvement and innovation. The economy of the XXI century is oriented learning. The promotion of entrepreneurship involves a cultural change based on the premise that people can improve their quality of life and others, taking to themselves the task of leading and defining their own destiny and construyedo own. It is not just to produce more with less cost, which is intended primarily is Formenta the innovation process in the smartest way possible. In this context, universities acquire vital importance. At this, the Ibero-American space should be the scene of collaborations for joint actions of generation capacity existing knowledge, is the crucial dimension of any development efforts in countries like Brazil. Today's participation microenterprise is considered key to the development of any economy. As entrepreneurial attitude is considearada the gateway for business creation. Key words: entrepreneurship, microenterprise, incubation.
Novel Strategy to Assess the Neurotoxicity of Organic Solvents Such as Glycol Ethers: Protocol for Combining In Vitro and In Silico Methods With Human-Controlled Exposure Experiments

Background Chemicals are not required to be tested systematically for their neurotoxic potency, although they may contribute to the development of several neurological diseases. The absence of systematic testing may be partially explained by the current Organisation for Economic Co-operation and Development (OECD) Test Guidelines, which rely on animal experiments that are expensive, laborious, and ethically debatable. Therefore, it is important to understand the risks to exposed workers and the general population exposed to domestic products. In this study, we propose a strategy to test the neurotoxicity of solvents using the commonly used glycol ethers as a case study. Objective This study aims to provide a strategy that can be used by regulatory agencies and industries to rank solvents according to their neurotoxicity and demonstrate the use of toxicokinetic modeling to predict air concentrations of solvents that are below the no observed adverse effect concentrations (NOAECs) for human neurotoxicity determined in in vitro assays. Methods The proposed strategy focuses on a complex 3D in vitro brain model (BrainSpheres) derived from human-induced pluripotent stem cells (hiPSCs). This model is accompanied by in vivo, in vitro, and in silico models for the blood-brain barrier (BBB) and in vitro models for liver metabolism. The data are integrated into a toxicokinetic model. Internal concentrations predicted using this toxicokinetic model are compared with the results from in vivo human-controlled exposure experiments for model validation. The toxicokinetic model is then used in reverse dosimetry to predict air concentrations, leading to brain concentrations lower than the NOAECs determined in the hiPSC-derived 3D brain model. These predictions will contribute to the protection of exposed workers and the general population with domestic exposures. Results The Swiss Centre for Applied Human Toxicology funded the project, commencing in January 2021. The Human Ethics Committee approval was obtained on November 16, 2022. Zebrafish experiments and in vitro methods started in February 2021, whereas recruitment of human volunteers started in 2022 after the COVID-19 pandemic–related restrictions were lifted. We anticipate that we will be able to provide a neurotoxicity testing strategy by 2026 and predicted air concentrations for 6 commonly used propylene glycol ethers based on toxicokinetic models incorporating liver metabolism, BBB leakage parameters, and brain toxicity. Conclusions This study will be of great interest to regulatory agencies and chemical industries needing and seeking novel solutions to develop human chemical risk assessments. It will contribute to protecting human health from the deleterious effects of environmental chemicals. International Registered Report Identifier (IRRID) DERR1-10.2196/50300
The role of platelets in sepsis

Summary Platelets are small circulating anucleate cells that are of crucial importance in haemostasis. Over the last decade, it has become increasingly clear that platelets play an important role in inflammation and can influence both innate and adaptive immunity. Sepsis is a potentially lethal condition caused by detrimental host response to an invading pathogen. Dysbalanced immune response and activation of the coagulation system during sepsis are fundamental events leading to sepsis complications and organ failure. Platelets, being major effector cells in both haemostasis and inflammation, are involved in sepsis pathogenesis and contribute to sepsis complications. Platelets catalyse the development of hyperinflammation, disseminated intravascular coagulation and microthrombosis, and subsequently contribute to multiple organ failure. Inappropriate accumulation and activity of platelets are key events in the development of sepsis-related complications such as acute lung injury and acute kidney injury. Platelet activation readouts could serve as biomarkers for early sepsis recognition; inhibition of platelets in septic patients seems like an important target for immune-modulating therapy and appears promising based on animal models and retrospective human studies.
Treatment Patterns and Outcomes of Anastomotic Leakage after Esophagectomy for Esophageal Cancer

Background Anastomotic leakage (AL) following esophagectomy represents a serious complication that often results in prolonged hospitalization and necessitates repeated interventions, including nothing-by-mouth (NPO) restriction, endoscopic vacuum therapy (EVT), or surgical repair. In this study, we evaluated the patterns and outcomes of AL treatment. Methods We retrospectively reviewed the medical records of patients who underwent esophagectomy for esophageal cancer at a single center between 2003 and 2020. Of 3,096 examined cases, 181 patients (5.8%) with AL were included in the study 114 patients (63%) with cervical anastomosis (CA) and 67 (37%) with intrathoracic anastomosis (TA). Results The incidence of AL was 11.9% in the CA and 3.2% in the TA group (p<0.001). Among patients with CA who developed AL, 87 (76.3%) were managed with NPO, 15 (13.2%) with EVT, and 12 (10.5%) with surgical repair. Over 90% of patients with cervical AL resumed an oral diet by the time of discharge, regardless of treatment method. Among patients with TA and AL, 36 (53.7%) received NPO, 25 (37.7%) underwent EVT, and 6 (9%) required surgery. Of these, 34 patients who were managed with NPO and 19 with EVT could resume an oral diet. However, only 2 patients who underwent surgery resumed an oral diet, and 2 patients required additional EVT. Conclusion Although patients with CA displayed a higher incidence of AL, their rate of successful oral intake exceeded that of those with TA, regardless of treatment method. Among patients exhibiting AL with TA, EVT was more commonly employed than in CA cases, and it appears effective.
Cryotherapy versus radiofrequency ablation in the treatment of dysplastic Barrett's esophagus with or without early esophageal neoplasia: a systematic review and meta-analysis.

Background/Aims Radiofrequency ablation (RFA) is the first-line therapy for dysplastic Barrett's esophagus (BE). Therefore, cryotherapy has emerged as an alternative treatment option. This study aimed to compare the efficacies of these two techniques based on the rates of complete eradication of intestinal metaplasia (CE-IM) and dysplasia (CE-D). Adverse events and recurrence have also been reported. Methods An electronic search was conducted using the Medline (PubMed), Embase, LILACS, and Google Scholar databases until December 2022. Studies were included comparing cryotherapy and RFA for treating dysplastic BE with or without early esophageal neoplasia. This study was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results Three retrospective cohort studies involving 627 patients were included. Of these, 399 patients underwent RFA, and 228 were treated with cryotherapy. There was no difference in CE-IM (risk difference [RD], -0.03; 95% confidence interval [CI], -0.25 to 0.19; p=0.78; I2=86%) as well as in CE-D (RD, -0.03; 95% CI, -0.15 to 0.09; p=0.64; I2=70%) between the groups. The absolute number of adverse events was low, and there was no difference in the recurrence rate. Conclusions Cryotherapy and RFA were equally effective in treating dysplastic BE, with or without early esophageal neoplasia.
Changes in the menstrual hygiene management facilities and usage among Bangladeshi school girls and its effect on school absenteeism from 2014 to 2018

ABSTRACT Background The lack of menstrual hygiene management (MHM) information and facilities in schools is a major contributor to adolescent girls’ school absenteeism in low- and middle-income countries like Bangladesh. Objectives This paper examines the changes over time in school MHM facilities, knowledge and perceptions among adolescent girls, in relation to school absenteeism between 2014 and 2018 in Bangladesh. Methods We examined changes in MHM and school absenteeism among schoolgirls using nationally representative data from the Bangladesh National Hygiene Baseline Survey 2014 and National Hygiene Survey 2018. Given the repetitive nature of our data and its clustering within participants, our method included performing descriptive analysis, bivariate analysis, and multivariate Generalised Estimating Equation (GEE) modelling to analyse these changes. Results Results showed that adolescent girls’ menstruation-related absenteeism decreased between 2014 and 2018. Percentage of adolescents who missed school decreased from 25% to 14% (PD: −11; CI: −16 to −6.1), while the average number of missed days reduced from 2.8 to 2.5 (PD: −0.33; CI: −0.57 to −0.10). In the GEE model, we found that living in rural areas (coef: −5.6; CI: −10.06 to −1.14), parental restrictions on going outside (coef: 4.47; CI: 0.75 to 8.2), education levels of girls (coef: −9.48; CI: −14.17 to −4.79), girl’s belief that menstruation affects school performance (coef: 23.32; CI: 19.71 to 26.93), and using old cloths (coef: −4.2; CI: −7.6 to −0.79) were significantly associated with higher absenteeism. However, participant’s age, type of school, knowledge of menstruation before menarche, receiving information regarding MHM, separate place for changing absorbents, and separate latrine and urine facility were not significantly associated with the changes in absenteeism over time. Conclusion This paper emphasised the associations between changes in school absenteeism, parental restrictions on students, students’ education levels, and menstruation-related misperceptions. Ongoing research, policy reviews, and targeted interventions to improve MHM perceptions among girls are required to provide long-term benefits for adolescent girls in Bangladesh.
Bulk versus Spectral Wave Parameters: Implications on Stokes Drift Estimates, Regional Wave Modeling, and HF Radars Applications

AbstractAccurate estimates of Stokes drift are necessary to quantify Lagrangian transport and upper-ocean mixing. These can be estimated from directional wave spectra. Here, a methodology for the reconstruction of such spectra is developed using partitioned bulk wave parameters provided by global wave models. These reconstructed spectra agree well with global wave model–simulated full spectra. Regional wave model simulations with reconstructed spectra as open boundary conditions lead to more accurate estimates of bulk wave parameters in the coastal ocean. Furthermore, the reconstructed directional spectra can be used to improve high-frequency (HF) radar–derived surface Lagrangian current estimates. Stokes drift vertical profiles from complete directional spectra are more accurate, and therefore coupled ocean circulation and wave models should incorporate spectral estimates for wave–current interaction studies. Based on model simulations conducted here, it is recommended that regional wave modeling studies.
Soil acidity impacts beneficial soil microorganisms

Soils harbor more diverse microbial populations than any other habitat on earth. Only a very small fraction of those organisms are responsible for any type of plant or animal disease. In fact, the vast majority of these microscopic soil organisms are highly beneficial in terms of nutrient cycling, soil tilth, and soil health. Because of their important roles in these crucial soil properties and their direct interactions with plants, beneficial soil microorganisms are also absolutely critical to soil fertility and plant nutrition. Unfortunately, the rapid acidification of soils in the inland Pacific Northwest is having detrimental impacts on the populations and effectiveness of beneficial soil microorganisms.
Genomic Architecture Predicts Tree Topology, Population Structuring, and Demographic History in Amazonian Birds

Abstract Geographic barriers are frequently invoked to explain genetic structuring across the landscape. However, inferences on the spatial and temporal origins of population variation have been largely limited to evolutionary neutral models, ignoring the potential role of natural selection and intrinsic genomic processes known as genomic architecture in producing heterogeneity in differentiation across the genome. To test how variation in genomic characteristics (e.g. recombination rate) impacts our ability to reconstruct general patterns of differentiation between species that cooccur across geographic barriers, we sequenced the whole genomes of multiple bird populations that are distributed across rivers in southeastern Amazonia. We found that phylogenetic relationships within species and demographic parameters varied across the genome in predictable ways. Genetic diversity was positively associated with recombination rate and negatively associated with species tree support. Gene flow was less pervasive in genomic regions of low recombination, making these windows more likely to retain patterns of population structuring that matched the species tree. We further found that approximately a third of the genome showed evidence of selective sweeps and linked selection, skewing genome-wide estimates of effective population sizes and gene flow between populations toward lower values. In sum, we showed that the effects of intrinsic genomic characteristics and selection can be disentangled from neutral processes to elucidate spatial patterns of population differentiation.