Miracle-dz/UniFAR-FTUs huggingface dataset:
I MPACT OF THE ICME-E ARTH G EOMETRY ON THE S TRENGTH OF THE A SSOCIATED G EOMAGNETIC S TORM : THE S EPTEMBER 2014 AND M ARCH 2015 E VENTS

: We investigate two abnormal CME-Storm pairs that occurred on 2014 September 10 - 12 and 2015 March 15 - 17, respectively. The ﬁrst one was a moderate geomagnetic storm (Dst min ∼ -75 nT) driven by the X1.6 high speed ﬂare-associated CME (1267 km s − 1 ) in AR 12158 (N14E02) near solar disk center. The other was a very intense geomagnetic storm (Dst min ∼ -223 nT) caused by a CME with moderate speed (719 km s − 1 ) and associated with a ﬁlament eruption accompanied by a weak ﬂare (C9.1) in AR 12297 (S17W38). Both CMEs have large direction parameters facing the Earth and southward magnetic ﬁeld orientation in their solar source region. In this study, we inspect the structure of Interplanetary Flux Ropes (IFRs) at the Earth estimated by using the torus ﬁtting technique assuming self-similar expansion. As results, we ﬁnd that the moderate storm on 2014 September 12 was caused by small-scale southward magnetic ﬁelds in the sheath region ahead of the IFR. The Earth traversed the portion of the IFR where only the northward ﬁelds are observed. Meanwhile, in case of the 2015 March 17 storm, our IFR analysis revealed that the Earth passed the very portion where only the southward magnetic ﬁelds are observed throughout the passage. The resultant southward magnetic ﬁeld with long-duration is the main cause of the intense storm. We suggest that 3D magnetic ﬁeld geometry of an IFR at the IFR-Earth encounter is important and the strength of a geomagnetic storm is strongly aﬀected by the relative location of the Earth with respect to the IFR structure.
Les inhibiteurs des histone-désacétylases en onco-hématologie

Resume Les inhibiteurs d’histone desacetylases (HDACi) correspondent a une nouvelle classe de molecules faisant actuellement l’objet de nombreuses publications en cancerologie. Ils ont demontre, par l’intermediaire de mecanismes multiples repartis sur l’ensemble des voies indispensables a la survie, la proliferation et la differenciation cellulaires, une activite antitumorale preclinique et clinique sur de nombreuses pathologies malignes. Ces resultats prometteurs ont conduit a l’approbation par la FDA de deux d’entre eux, le vorinostat et la romidepsin, dans le lymphome T cutane en rechute ou refractaire. Cette synthese a pour objectif, a la lumiere des dernieres communications et publications, de faire le point sur les connaissances actuelles sur les HDACi dans le domaine de l’hematologie maligne et sur les pistes en cours d’investigation.
index of real-time error correction within a noisy-channel framework of human

Recent evidence suggests that language processing is well-adapted to noise in the input (e.g., spelling or speech errors, misreading or mishearing) and that comprehenders readily correct the input via rational inference over possible intended sentences given probable noise corruptions. In the current study, we probed the processing of noisy linguistic input, asking whether well-studied ERP components may serve as useful indices of this inferential process. In particular, we examined sentences where semantic violations could be attributed to noise—for example, in “The storyteller could turn any incident into an amusing antidote”, where the implausible word “antidote” is orthographically and phonologically close to the intended “anecdote”. We found that the processing of such sentences—where the probability that the message was corrupted by noise exceeds the probability that it was produced intentionally and perceived accurately—was associated with a reduced (less negative) N400 effect and an increased P600 effect, compared to semantic violations which are unlikely to be attributed to noise (“The storyteller could turn any incident into an amusing hearse”). Further, the magnitudes of these ERP effects were correlated with the probability that the comprehender retrieved a plausible alternative. This work thus adds to the growing body of literature that suggests that many aspects of language processing are optimized for dealing with noise in the input, and opens the door to electrophysiologic investigations of the computations that support the processing of imperfect input.
Leishmania major Library of Vaccination with an Expression Genomic Protective Immune Responses Induced by

To develop an effective vaccine against the intracellular protozoan parasite Leishmania spp. , we investigated the feasibility of expression library immunization (ELI) in the mouse. Genomic expression libraries of L. major were constructed and used to immunize mice. One of the three libraries (L1, with 10 5 clones) induced a signiﬁcant protective immune response and delayed the onset of lesion development in highly susceptible BALB/c mice after i.m. immunization, compared with control mice immunized with the empty vector (EV). L1 was then divided into ﬁve sublibraries of ; 2 3 10 4 clones each. Mice immunized with one of the sublibraries (SL1A) developed an even stronger protective effect than that induced by L1. SL1A was further divided into 20 sublibraries (SL2) of ; 10 3 clones each. One of the SL2 libraries (SL2G) induced a strong protective effect against L. major infection. In direct comparative studies, the protective effect of the sublibraries was in the order of SL2G > SL1A > L1. Lymphoid cells from mice vaccinated with SL2G produced more IFN- g and NO, compared with cells from control mice injected with EV. Serum from the vaccinated mice also contained more parasite-speciﬁc IgG2a Ab, compared with controls. Therefore, these data demonstrate that ELI is feasible against this complex intracellular parasitic infection, by preferentially inducing the development of Th1 responses. Furthermore, by sequential division of the libraries, this approach may be used to enrich and identify protective genes for effective gene vaccination against other parasitic infections. The Journal of Immunology, 1999, 163: 1467–1472.
Closing the GARCH gap

It is the purpose of this paper to build a bridge between continuous time models which are central in the literature on pricing of derivatives and (weak) GARCH processes in discrete time which are often parsimonious descriptions of the observed data. The properties of continuous time processes which exhibit GARCH type behavior at all discrete frequencies will be discussed. Several examples of such processes illustrate the genera] theory. The class of continuous time GARCH mod- els can be divided into two sub-classes. In the first group (GARCH diffusions) the sample paths are continuous and in the other group (GARCH jump processes) the sample paths are erratic. A simple and complete characterization of both types is given in terms of the behavior of the kurtosises of the implied discrete time GARCH processes. These two groups of GARCH processes can be described by three and four coefficients, respectiveh~, and explicit formulas of all implied discrete time GARCH parameters are available. ~loreover, knowledge of the discrete time GARCH parameters at only one frequency completely detetmines the coefficients of the GARCH process. So, in estimating a continuous time G:1RCli process it suffices to estimate the discrete time GARCH parameters for the available data frequency. The analysis carries over to models with an autoregressive component containing the well-known Ornstein-Ctilenbeck process as a special example. GARCH models contains models with smooth as wel] as non-smooth sample paths. Our results suggest straightfor~ti'ard tests to distinguish beUti'een these two classes. Finally, our results provide an explanation why fat-tailed conditional distributions are obtained, without exception, in empirical work.
hip and knee arthroplasties. Incisional negative pressure wound therapy dressings (inpWTd) in routine primary complications

test, p = 0.003). There was a significantly reduced number of dressing changes (mean difference 1.7, 95% cI 0.8 to 2.5, p = 0.002), and a trend to a significant four-fold reduction in reported post-operative surgical wound complications (8.4% control; 2.0% Based role in patients primary hip and knee arthroplasty to achieve hospital and the of
Edinburgh Research Explorer The business of being a user

The paper extends the concept of “user” to account for a new, more formalized role that some client organizations play in the diffusion of packaged enterprise systems. Package vendors are attempting to draw parts of their user base into activities related to the promotion, selling, and commodification of systems. Users, in turn, appear willing to help construct these systems as objects of consumption for others. This can appear to be rather idiosyncratic behavior. Information Systems scholars have argued that relations between packaged enterprise system vendors and users are attenuated. Why might the user help the vendor market its systems in this way? What benefits accrue from it? And what role are users performing in carrying out this work? To show how this is becoming a general facet of the work of some packaged enterprise system users, we develop the notion of “reference actor,” which is an extension of the earlier Information Systems concept of “social actor. ” In combining insights from the social shaping of technology and the biography of artifacts, and drawing on long-term qualitative fieldwork, we analyze this new actor role in relation to expectations and commitments coming from the wider packaged enterprise system community. In return for the help provided to prospective adopters, reference actors are also able to gather various kinds of benefits for themselves and others. In particular, they build closer relations with vendors such that they can influence product development strategies.
Exploring applications of Frozen Newton Method in the design of digital filter

Digital filters are popularly used in digital signal processing. The design of these filters can be done using different methods of which the rectangular window method and Frequency sampling methods are commonly used. Filter design using wavelet coefficients also shows better response. In this paper, we explore the use of the Frozen Newton method in improving the response of the filter designed using these methods. This iterative computing is applied considering the Taylor series expansion of the function up to the first order term called the Jacobian
5/RT/02 CENTRAL BANK OF IRELAND Research Technical Paper A Note on the Cointegration of Consumption, Income, and Wealth by Jeremy

note the cointegration consumption, Abstract Lettau and Ludvigson (2001) argue that a log-linearized approximation to an aggregate budget constraint predicts that log consumption, assets, and labor income will be cointegrated. They conclude that this cointegrating relationship is present in U.S. data, and that the estimated cointegrating residual forecasts future asset growth. This note examines whether the cointegrating relationship suggested by Lettau and Ludvigson’s theoretical framework actually exists. We demonstrate that we cannot reject the hypothesis that cointegration is absent from the data once we employ measures of consumption, assets, and labor income that are jointly consistent with an underlying budget constraint. By contrast, Lettau and Ludvigson use a set of variables that do not belong together in an aggregate budget constraint, thereby testing a cointegrating relationship that is not implied by their theory.
Perspective of tinalized microorganisms in the development of safe probiotics

normal stool. In a multicenter, randomized, double-blind, controlled study, the use of formula containing heat-killed B. breve C50 and S. thermophilus 065 in children at high risk of atopy reduced the incidence of digestive and respiratory allergic events. Recently, products containing various tyndallized probiotics strains have appeared on the market. These are L. reuteri , B. breve and xyloglucan for the treatment of colic in adults and children, L. acidophilus HA122 with extracts of chamomile and lemon balm for the treatment of colic in children, a complex of tyndalized lacto- and bifidobacteria with gelatinate tanat for the treatment of intestinal dysbacteriosis associated with diarrhea. Conclusion. Heat-killed probiotics are no less effective than live bacteria and have benefits such as greater safety, ease of standardization, transportation, and storage. They are an alternative to live probiotics and open up the possibility of using them to treat various diseases and conditions.
TUBE STRUCTURES, SPACES AND EXTENSION OF CR DISTRIBUTIONS

We consider rough tubes X + i R m ⊂ C m , where X ⊂ R m is a measurable set, and extend the notion of CR function to the space L ∞ ( X,h p ( R m )), where h p ( R m ), 0 < p < ∞ , is Goldberg’s semilocal Hardy space. We show that if X is the image of some connected manifold by some C 1 map, then all such CR functions can be extended to the convex hull of the tube as CR functions ∈ L ∞ (ch( X ) ,h p ( R m )). This extends previous work of Boggess.
A 1-Year

OBJECTIVE. Postnatal steroids (PNSs) are used frequently to prevent or treat chronic lung disease (CLD) in the very low birth weight (VLBW) infant, and their use continues despite concerns regarding an increased incidence of longer-term neurodevelopmental abnormalities in such infants. More recently, there has been a suggestion that corticosteroids may be a useful alternative therapy for hypotension in VLBW infants, but there have been no prospective reports of such use for a current cohort of VLBW infants. METHODS. The California Perinatal Quality Care Collaborative (CPQCC) requested members to supplement their routine Vermont Oxford Network data collection with additional information on any VLBW infant treated during their hospital course with PNS, for any indication. The indication, actual agent used, total initial daily dose, age at treatment, type of respiratory support, mean airway pressure, fraction of inspired oxygen, and duration of ﬁrst dosing were recorded. RESULTS. From April 2002 to March 2003 in California, 22 of the 62 CPQCC hospitals reported supplemental data, if applicable, from a cohort of 1401 VLBW infants (expanded data group [EDG]), representing 33.2% of the VLBW infants registered with the CPQCC during the 12-month period. PNSs for CLD were administered to 8.2% of all VLBW infants in 2003, 8.6% of infants in the 42 hospitals that did not submit supplemental data (routine data-set group, compared with 7.6% in EDG hospitals). Of the 1401 VLBW infants in the EDG, 19.3% received PNSs; 3.6% received PNSs for only CLD, 11.8% for only non-CLD indications, and 4.0% for both indications. At all birth weight categories, non-CLD use was signiﬁcantly greater than CLD use. The most common non-CLD indication was hypotension, followed by extubation stridor, for which 36 (16.3%) infants were treated. For hypotension, medications used were hydrocortisone followed by dexamethasone. Infants treated with PNSs exclusively for hypotension had a signiﬁcantly higher incidence of intraventricular hemorrhage, periventricular leukomalacia, and death when compared with infants treated only for CLD or those who did not receive PNSs.
applied the Regulation of TRPV1 by phosphoinositide (4,5)-bisphosphate: role of membrane asymmetry

Background 2 ) activates or inhibits TRPV1 is controversial. Results : PI(4,5)P 2 in the intracellular leaflet activates TRPV1, whereas PI(4,5)P 2 in the extracellular leaflet inhibits TRPV1. Conclusion : Inhibition by PI(4,5)P 2 in the extracellular leaflet may explain previous findings that TRPV1 reconstituted into PI(4,5)P 2 containing liposomes is inhibited. Significance : PI(4,5)P 2 in the physiologically relevant leaflet (the intracellular leaflet) of the membrane activates TRPV1. Abstract Membrane asymmetry is essential for generating second messengers that act in the cytosol and for trafficking of membrane proteins and membrane lipids, but the role of asymmetry in regulating
Analysis of Shop Sign Colors in Joong-Gu, Seoul — Nadulgage and Convenience Stores

The South Korean government is attempting to revive small supermarkets by branding them as ″Nadulgage. ″ These efforts include support to change retail store signs; however, in reality, the government has only provided emblem designs thus far. Based on previous studies, this study reviews the current status and features of sign colors for both Nadulgage and convenience stores in the Jung-gu area. In addition, after analyzing color images using the Moon–Spencer Theory, PCCS tone chart and I.R. I Color Emotional Quotient as analysis tools, we compare the characteristics of Nadulgage and convenience stores and draw our implications. The colors of Nadulgage signs still display the characteristics of colors that were elucidated in previous research. Moreover, the dominant colors of Nadulgage signs have a higher ratio of colors belonging to the contrast area compared with those belonging to the other groups. This makes their impression confusing when compared with the impression of the colors of convenience store signs. Therefore, reselection of the dominant colors that can portray the unique identity of a Nadulgage should be prioritized, and the color-matching relationship between dominant colors, assorted colors, and accent colors should be established in more detail. Thus, comparing Nadulgage and convenience stores may help in obtaining useful data.
DDoS-as-a-Service: Investigating Booter Websites

Why should you care about Distributed Denial of Service (DDoS) attacks? If your Internet home connection would be the target of a DDoS attack, then not only your connectivity is gone, but also your telephone and TV programs. This is because many homes have triple-play-service (a package offered by Internet providers that includes TV programs and telephone service together with the Internet connectivity). Looking from a company perspective, in 2015, small and medium companies reported spending more than $US50,000 recovering from a DDoS attack, while large corporations reported an average $US410,000. This figure increased drastically in 2017: large corporations reported $US2.5M in revenue loss as a consequence of a DDoS attack. Given the rapid increase observed above, we can expect that these costs will continue to rise, just as our society's increased dependence on networked services. Until 2013, DDoS attacks were something that only a (relatively) skilled hacker could perform, and that required specialist knowledge. In 2013, the hacker community began offering DDoS attacks via Websites easily findable via popular searching engines (Google and Bing). Websites called ``booters'' and ``stressers'' offer, for very affordable prices, for example, starting from less than $US5, to perform as many DDoS attacks as requested for a month period. Between 2014 and 2017 booters were considered by network security companies to be the main responsible for the increase in (DDoS) attack power and frequency, making the investigation in this thesis even more critical and timely. The main contributions of this these are that we show: (1) how to find booters, (2) how to detect their clients accessing and using them, (3) the characteristics of their attacks, (4) what third-party companies are used by them to maintain their operations, (5) which booters are the most dangerous and (6) which ethical arguments can be used to support mitigation actions against them. Finally, while the core of this thesis is based on scientific publications, a number of solutions proposed in this thesis are actively deployed by network operators worldwide. In addition to this, the methodologies in this thesis are used by the Dutch High Tech Crime Unit for collecting evidences for prosecution cases.
Compassion Fatigue Among Practicing and Future Psychiatrists: A National Perspective

Compassion fatigue is a set of emotions and behaviors that occur as a result of assisting a person who is suffering. Compassion fatigue, burnout, and low compassion satisfaction are all hazards that professional caregivers encounter. However, in comparison to non-medical workers, psychiatrists were found to have higher levels of compassion fatigue. We conducted a cross-sectional study that targeted all psychiatrists and psychiatric trainees enlisted in Saudi Arabia at the only registering body, the Saudi Commission for Health Specialties (SCFHS). The SCFHS approved and sent an online survey consisting of a three-section questionnaire concerning sociodemographic, personal, and professional information and the Professional Quality of Life Scale (ProQOL 5). Compassion fatigue was found at an average level in 43.2% of participants, while 56.3% had a low level. An average level of burnout was found in 65.9% of participants, while 34.1% had a low level of burnout. Of all participants, 38.9% had an elevated level of compassion satisfaction. Participants who were diagnosed with psychiatric illness showed higher burnout scores (p<0.001). Divorced or separated participants had a higher compassion satisfaction score compared with single participants. A history of psychological trauma was associated with a higher compassion fatigue score (p=0.002). These findings supported the notion of trauma as a specific risk factor for compassion fatigue. They also attested to the huge burden among psychiatrists and psychiatric trainees as part of the nature of this profession. We advise developing systematic and proactive tools to screen for trauma and to support practicing and future psychiatrists, especially those at risk of compassion fatigue.
Inferring Cyber Threat Intelligence - A Knowledge Graph-based Approach (cid:63)

Security analysts prepare threat analysis upon investigating an attack, an emerging cyber threat, or a recently discovered vulnerability. Threat intelligence on malware attacks and campaigns is shared on blog posts, reports, analyses, and tweets with varying technical details. Other security analysts use this intelligence to inform them of emerging threats, indicators of compromise, attack methods, and preventative measures. Collectively known as threat intelligence, it is typically in an unstructured format and, therefore, challenging to integrate seamlessly into existing IDPS systems. In this paper, we propose a framework that aggregates and combines CTI - the openly available cyber threat intelligence information. The information is extracted and stored in a structured format using knowledge graphs such that the semantics of the threat intelligence can be preserved and shared at scale with other security analysts. We propose the ﬁrst semi-supervised open-source knowledge graph (KG) framework, TINKER, to capture cyber threat information and its context. Following TINKER, we generate a Cyberthreat Intelligence Knowledge Graph (CTI-KG). We demonstrate the eﬃcacy of CTI-KG using diﬀerent use cases and its application for security analysts.
Estimation of User Coordinates via Channel Charting and MUSIC

—We present a new way of producing a channel chart in polar coordinates. We estimate the angle of arrival θ and the distance between the base station and the user equipment ρ using the MUSIC algorithm and inverse of the root sum squares of channel coefﬁcients (ISQ) or linear regression (LR). We compare this method with the channel charting algorithms principal component analysis (PCA), Samson’s method (SM), and autoencoder (AE). We show that ISQ and LR outperform all three in both performance and complexity. The performance of LR and ISQ are close, with ISQ having less complexity.