Miracle-dz/UniFAR-FTUs huggingface dataset:
Structural and Stratigraphical Setting of the Faiyah Range, Northwestern Oman Mountain Front, United Arab Emirates

The Faiyah Range belongs to a group of regional ridges that formed by post-obduction folding of the Upper Cretaceous-Tertiary sedimentary rocks exposed along the western margin of the Northern Oman Mountains. The Faiyah Anticline, generally trends north-northeast to south-southwest with thrust faults striking parallel to the fold axis. The anticlinal hinge was later displaced by a dextral strike-slip fault, named here as the Faiyah Fault, into two segments. The northeastern segment includes Jebels Rumaylah, Faiyah and Mulayhah, and the southwestern segment includes Jebels Buhays and Aqabah. The anticline is interpreted to result from northeast-southwest compression during the Tertiary. In the Faiyah Range the neoautochthonous sedimentary rocks are the Maastrichtian Qahlah and Simsima formations, and the Eocene Dammam Formation. Stratigraphic evidence shows that the lower part of the Qahlah was deposited in a non-marine environment while the upper part was deposited during a marine transgression. The Simsima was deposited in a shallow-marine environment. These units unconformably overlap the allochthonous Semail Ophiolite. The microfaunal content of the so-called Muthaymimah Formation (? Tertiary), of earlier authors, indicates that it is of Maastrichtian age in the Faiyah Range. This sequence is also conformable to the Simsima and therefore it is considered to be the upper member of the Simsima in this area.
Analysis of the Influence of Regional Leading Sectors on Economic Growth in West Aceh District, Aceh Province

West Aceh district is one of the old towns in the South West Region. This district is identified as the region which has various leading economic potentials especially in agricultural sector that can increase it’s economic growth. This study aims to analyze the influence of regional leading sectors on economic growth in this district. Furthermore, the data used in this study is secondary data (1997-2016) which is retrieved by Central Bureau of Statistics Aceh Province (BPS) and Regional Development Planning Agency (Bappeda) of West Aceh District. The method used is quantitative method applying Location Quotient (LQ) analysis and simple linear regression. Based on the result of the research, it was obtained that the correlation coefficient value is 0.642 and the coefficient of determination value is 41.2%. Moreover, regression equation value is Y = 7.953 – 1.064X1+e. Therefore, it is suggested that local government increases the previous leading sectors and further diverts the potential of non-leading sectors become potential leading sectors thus regional economic growth is increasing.
Colocynth (Citrullus colocynthis) Flesh Extract Suppresses Adipogenesis by Down-Regulating Adipogenic Transcription Factors and Their Target Genes in 3T3-L1 Preadipocytes

Citrullus colocynthis, a member of the Cucurbitaceae family, is widely distributed in North Africa. The fruits are recognized for their wide range of medicinal uses and promising pharmaceutical potential. The present study aimed to investigate the anti-obesity effect of the ethanol extract of colocynth flesh (FCEE) in 3T3-L1 cells following treatment at different doses. The viability of 3T3-L1 preadipocytes was analyzed via MTT assay and triglycerides were stained with Oil red O to assess lipid accumulation. Additionally, adipogenesis-related gene expression was quantified via qRT-PCR. FCEE (0 - 150 μg/mL) dose-dependently suppressed intracellular triglyceride accumulation during the adipogenesis by 23% and 66% at 100 and 150 μg/mL, respectively, but did not affect cell viability. Analysis of the time-dependence of the effect of FCEE demonstrated that the greatest anti-adipogenic activity was observed during the early stages of differentiation. FCEE also decreased GPDH activity in a dose-dependent manner, with 98% decrease observed at 150 μg/mL. In addition, at same range of FCEE concentrations, the main transcription factors, including CCAAT/enhancer binding protein α (C/EBPα), peroxisome proliferator activated receptor γ (PPARγ), and sterol regulatory element-binding protein 1c (SREBP-1c), were downregulated by 90%, 89%, and 89%, respectively at 150 μg/mL. As these are the master regulators of adipogenesis. The inhibition of their downstream target genes was also observed. Colocynth may be useful in the treatment of obesity owing to its powerful effects on fat, which result in changes to adipocyte differentiation and fat mobilization.
Recent Advances in Deep Reinforcement Learning Applications for Solving Partially Observable Markov Decision Processes (POMDP) Problems Part 2 - Applications in Transportation, Industries, Communications and Networking and More Topics

The two-part series of papers provides a survey on recent advances in Deep Reinforcement Learning (DRL) for solving partially observable Markov decision processes (POMDP) problems. Reinforcement Learning (RL) is an approach to simulate the human’s natural learning process, whose key is to let the agent learn by interacting with the stochastic environment. The fact that the agent has limited access to the information of the environment enables AI to be applied efficiently in most fields that require self-learning. It’s essential to have an organized investigation—we can make good comparisons and choose the best structures or algorithms when applying DRL in various applications. The first part of the overview introduces Markov Decision Processes (MDP) problems and Reinforcement Learning and applications of DRL for solving POMDP problems in games, robotics, and natural language processing. In part two, we continue to introduce applications in transportation, industries, communications and networking, etc. and discuss the limitations of DRL.
Statin-Associated Myopathy: Emphasis on Mechanisms and Targeted Therapy

Hyperlipidemia is a major risk factor for cardiovascular morbidity and mortality. Statins are the first-choice therapy for dyslipidemias and are considered the cornerstone of atherosclerotic cardiovascular disease (ASCVD) in both primary and secondary prevention. Despite the statin-therapy-mediated positive effects on cardiovascular events, patient compliance is often poor. Statin-associated muscle symptoms (SAMS) are the most common side effect associated with treatment discontinuation. SAMS, which range from mild-to-moderate muscle pain, weakness, or fatigue to potentially life-threatening rhabdomyolysis, are reported by 10% to 25% of patients receiving statin therapy. There are many risk factors associated with patient features and hypolipidemic agents that seem to increase the risk of developing SAMS. Due to the lack of a “gold standard”, the diagnostic test for SAMS is based on a clinical criteria score, which is independent of creatine kinase (CK) elevation. Mechanisms that underlie the pathogenesis of SAMS remain almost unclear, though a high number of risk factors may increase the probability of myotoxicity induced by statin therapy. Some of these, related to pharmacokinetic properties of statins and to concomitant therapies or patient characteristics, may affect statin bioavailability and increase vulnerability to high-dose statins.
Novel saturation transfer difference (STD) NMR approaches to understand biologically relevant protein-carbohydrate interactions

Saturation transfer difference (STD) NMR spectroscopy is a powerful NMR technique extensively used to obtain epitope maps of ligands binding to biologically relevant protein receptors. This allows to reveal semi-quantitative structural details of the interaction, which is key to direct lead optimization efforts in drug discovery. However, it does not give information about the nature of the amino acids surrounding the ligand in the binding pocket. In this thesis, the main effort has been put to develop two novel implementations of STD NMR, aimed at elucidating the surroundings of the ligand (i.e., the amino acids lining the binding pocket, or an adjacent bound ligand) in biologically relevant complexes. First, we report the development of the novel “DiffErential EPitope mapping STD NMR” (DEEP‐STD NMR), a method producing differential epitope maps through i) differential frequency and/or ii) differential solvent (D2O/H2O) STD NMR experiments. These two approaches provide complementary information on the architecture of the binding pocket. The second novel method we propose is “Inter-ligand STD NMR” (IL-STD NMR), which relies on on-ligand differential frequency STD NMR to detect contacts between ligands bound to adjacent sites of a receptor. These novel STD NMR methodologies, in combination with traditional STD NMR and computational tools, have been applied to the study of two systems: the interactions of Cholera Toxin subunit B (CTB) with a set of promising inhibitors; and the interactions of an intramolecular trans-sialidase from Ruminococcus gnavus, a gut microbiota symbiont, with a set of mucin-related sialylated ligands. In the first study, we discovered the existence of a hitherto unknown binding subsite in the GM1 binding site of CTB. In the second study, we provided the first 3D molecular model of a Michaelis complex for an IT-sialidase. In both cases, we demonstrate that our newly developed approaches increase the level of resolution of STD NMR, widening its potential to impact the field of ligand design for biologically relevant receptors.
ANALYSIS AND EVALUATION OF MULTIPLE-CHOICE TEST ITEMS AND TEST DESIGN: A STUDY ON APPLICATION OF ITEM RESPONSE THEORY

Bài viết trình bày kết quả ứng dụng lý thuyết ứng đáp câu hỏi với mô hình 2 tham số vào việc phân tích, đánh giá câu hỏi và xây dựng đề thi trắc nghiệm khách quan. Dựa trên việc phân tích dữ liệu kết quả thi của sinh viên (không thuộc chuyên ngành Tiếng Anh) đối với các đề thi Tiếng Anh 1 được sử dụng tại Trường Đại học Đồng Tháp từ năm 2017 đến 2021 bằng phần mềm R (gói ltm), nghiên cứu đã chỉ ra những câu hỏi đạt yêu cầu, đủ điều kiện để sử dụng trong các đề thi và những cầu hỏi chưa đạt yêu cầu, cần phải được xem xét lại để điều chỉnh, cải tiến. Trong đó, một số câu hỏi được sử dụng trong các đề thi có dấu hiệu bất thường, vi phạm nghiệm trọng về giới hạn giá trị các tham số độ khó, độ phân biệt cần phải được loại bỏ ra khỏi đề thi. Ngoài ra, kết quả nghiên cứu còn cho thấy các đề thi trên đều có ý nghĩa đo lường mức năng lực khá thấp (dưới 0.0 theo thang đo năng lực). Bên cạnh đó, nghiên cứu đã giới thiệu cách vận dụng công cụ đường cong thông tin vào việc xây dựng các đề thi giúp đo lường chính xác năng lực của người học dựa trên các tham số đặc trưng của các câu hỏi.
In Physically Active Patients Predisposed to Bone-Muscle Attrition Receiving Androgen Deprivation Therapy for Prostate Cancer Treatment, Prospective MRI Evaluation Does Not Demonstrate Significant Muscle Alteration

Department of radiology at the University of Texas at Southwestern Medical Center Department of radiology at the University of Texas at Southwestern Medical Center Department of radiology at the University of Texas at Southwestern Medical Center Department of radiology at the University of Texas at Southwestern Medical Center Department of internal medicine at the University of Texas at Southwestern Medical Center Department of internal medicine at the University of Texas at Southwestern Medical Center Department of radiology at the University of Texas at Southwestern Medical Center
Dynamic Variations of 3′UTR Length Reprogram the mRNA Regulatory Landscape

This paper concerns 3′-untranslated regions (3′UTRs) of mRNAs, which are non-coding regulatory platforms that control stability, fate and the correct spatiotemporal translation of mRNAs. Many mRNAs have polymorphic 3′UTR regions. Controlling 3′UTR length and sequence facilitates the regulation of the accessibility of functional effectors (RNA binding proteins, miRNAs or other ncRNAs) to 3′UTR functional boxes and motifs and the establishment of different regulatory landscapes for mRNA function. In this context, shortening of 3′UTRs would loosen miRNA or protein-based mechanisms of mRNA degradation, while 3′UTR lengthening would strengthen accessibility to these effectors. Alterations in the mechanisms regulating 3′UTR length would result in widespread deregulation of gene expression that could eventually lead to diseases likely linked to the loss (or acquisition) of specific miRNA binding sites. Here, we will review the mechanisms that control 3′UTR length dynamics and their alterations in human disorders. We will discuss, from a mechanistic point of view centered on the molecular machineries involved, the generation of 3′UTR variability by the use of alternative polyadenylation and cleavage sites, of mutually exclusive terminal alternative exons (exon skipping) as well as by the process of exonization of Alu cassettes to generate new 3′UTRs with differential functional features.
The Prevalence of Risky Behaviours in Traffic that can Lead to Traumatic Brain

Introduction: Traffic accidents are a common cause of traumatic brain injuries. Such injuries are often associated with problematic behaviour i.e., violations of the Traffic Safety Act. Driving under the influence of intoxicants and non-compliance with traffic signals often cause traffic accidents, and not wearing a crash helmet or not wearing a protective seat belt increase the possibility of developing a traumatic brain injury. Objective: The aim of this study is to examine the prevalence of risky behaviours in traffic that can lead to traumatic brain injury and to examine differences according to gender. It is assumed that the most common risky behaviour is failure to wear a crash helmet and that the male participants will show a higher prevalence of risky behaviour compared to women. Methods: The measuring instrument is a questionnaire consisting of nine statements. The questionnaire was filled out by a sample of 302 people in Croatia. The IBM SPSS Statistics 22 program was used for data processing. The prevalence of risky behaviours was expressed in percentages, and the Pearson’s Chi-Square was used to examine the differences between male and female participants. Results: The results show that risky behaviours in traffic are present, especially not wearing a crash helmet while riding a bicycle, running across the road on a red light, and not wearing a seat belt in a car whilst sitting in the back seat. The male participants showed a higher prevalence of risky behaviour compared to women. Conclusion: To reduce the number of traffic accidents that can lead to traumatic brain injury, it is important to act on risky behaviours in traffic. Public health policies and legislation are one way of prevention. In addition, it is important to inform, educate and raise public awareness about this global problem. In order to implement the necessary preventative measures, one should be aware of the prevalence of the risky behaviours in traffic that can lead to traumatic brain injury and of the groups that are more willing to take risks in traffic.
A rare case of L5-S1 right severe foraminal stenosis and paramedian disc herniation result in foot drop of right lower extremity: A case report

Objective: the authors presented a extremely rare case of severe foraminal stenosis combined with huge lateral lumbar disc herniation Case presentation: The authors presented a 74 – year old, male with type II chronic diabetes, had severe pain of the dermatomal distribution of L5, S1 nerve roots, and foot-drop of the right lower limb. When we evaluated the patient’s MRI, the huge paramedian disc herniation of the right L5-S1 level was seen and the right L5-S1 laminotomy and discetomy were planned for the treatment of the patient. However, the clinical symptoms were not completely correlated with that MRI findings so that, we re-checked the MRI, particularly at the lumbosacral region, and the right severe foraminal stenosis of L5-S1 level was found. The patient underwent surgery with facetectomy, transforaminal interbody fusion, and pedicle screw fixation. After the operation, the patient has quickly reduced radiating pain of the right lower extremity, although the foot-drop was not improved. Because of the huge lateral lumbar disc herniation impression, that could affect the assessing the patient’s injury correctly, leaded consequences of a missing diagnosis of foraminal stenosis and inadequate surgery method. Conclusion: It is essential to detail examination of the clinical manifestations and thorough assessment of MRI for evaluation of the correlation between the physical examination and MRI findings before making the decision of surgical method.
“The Heart is a House”: A Heuristic for Generating Cardiac Differential Diagnoses

BACKGROUND Differential diagnosis (DDx) is a core clinical reasoning skill that all medical students and physicians must acquire and develop. Metamemory techniques (MMTs), including mnemonic devices and other heuristics, are frequently taught to students as a means of enhancing DDx generation. The Heart is A House (HIAH), an MMT that works by prompting students to think about cardiac disease in terms of four structural subsystems, can be used to facilitate the generation of cardiac differentials, but its efficacy has not been studied. METHODS In a 3-hour DDx workshop, second-year medical students were given a brief case vignette of a patient with chest pain and dyspnea and asked to generate initial differential diagnoses before and after learning HIAH. Descriptive statistics and paired T-tests were used to compare the sizes of cardiac-only and total differentials pre-/post-HIAH. Cardiac diagnoses were classified according to the structural categories described by HIAH, and Simpson's Diversity Index (SDI) was used to evaluate the effect of HIAH on the variety of cardiac diagnoses produced. RESULTS All students in the course (N = 111) submitted pre-post differential lists. The mean number of diagnoses included in their differentials did not change significantly after exposure to HIAH (7.98 vs. 8.71, P = .09). However, the number of potentially correct cardiac diagnoses increased from 1.79 to 4.75 (P < .0001), and the variety of structure/function cardiac categories considered by students increased more than twofold (from an SDI of 0.16 to 0.4, P < .0001). These increases were accompanied by a small increase in incorrect diagnoses ( + 2.47%, P = .0003) and a larger decrease in potentially correct noncardiac diagnoses (−41.88%, P < .0001). CONCLUSION The use of HIAH was associated with an increase in the size and variety of cardiac differentials. This increase may have come at the cost of a reduced noncardiac differential. Educators may find HIAH useful for guiding students as they reason through cases involving potential cardiac etiologies. As with all heuristics, care must be exercised to avoid introducing unwanted bias.
Recording true oxygen reduction capacity during photosynthetic electron transfer in Arabidopsis thylakoids and intact leaves

Reactive oxygen species (ROS) are generated in electron transport processes of living organisms in oxygenic environments. Chloroplasts are plant bioenergetics hubs where imbalances between photosynthetic inputs and outputs drive ROS generation upon changing environmental conditions. Plants have harnessed various site-specific thylakoid membrane ROS products into environmental sensory signals. Our current understanding of ROS production in thylakoids suggests that oxygen (O2) reduction takes place at numerous components of the photosynthetic electron transfer chain (PETC). To refine models of site- specific O2 reduction capacity of various PETC components in isolated thylakoids, the stoichiometry of oxygen production and consumption reactions, associated with H2O2 accumulation, was quantified using membrane inlet mass spectrometry and specific inhibitors. Combined with P700 spectroscopy and electron paramagnetic resonance spin trapping, we demonstrate that electron flow to PSI is essential for H2O2 accumulation during light-induced photosynthetic electron transport process. Further leaf disc measurements provided clues that H2O2 from PETC has a potential of increasing mitochondrial respiration and CO2 release. One sentence summary Photosynthetically derived H2O2 only accumulates at Photosystem I and may trigger cooperation with mitochondria during stress
Selective Enhancement of the Cell-Permeabilizing Activity of Adenylate Cyclase Toxin Does Not Increase Virulence of Bordetella pertussis

The whooping cough agent, Bordetella pertussis, secretes an adenylate cyclase toxin–hemolysin (CyaA, ACT, or AC-Hly) that catalyzes the conversion of intracellular ATP to cAMP and through its signaling annihilates the bactericidal activities of host sentinel phagocytes. In parallel, CyaA permeabilizes host cells by the formation of cation-selective membrane pores that account for the hemolytic activity of CyaA. The pore-forming activity contributes to the overall cytotoxic effect of CyaA in vitro, and it has previously been proposed to synergize with the cAMP-elevating activity in conferring full virulence on B. pertussis in the mouse model of pneumonic infection. CyaA primarily targets myeloid phagocytes through binding of their complement receptor 3 (CR3, integrin αMβ2, or CD11b/CD18). However, with a reduced efficacy, the toxin can promiscuously penetrate and permeabilize the cell membrane of a variety of non-myeloid cells that lack CR3 on the cell surface, including airway epithelial cells or erythrocytes, and detectably intoxicates them by cAMP. Here, we used CyaA variants with strongly and selectively enhanced or reduced pore-forming activity that, at the same time, exhibited a full capacity to elevate cAMP concentrations in both CR3-expressing and CR3-non-expressing target cells. Using B. pertussis mutants secreting such CyaA variants, we show that a selective enhancement of the cell-permeabilizing activity of CyaA does not increase the overall virulence and lethality of pneumonic B. pertussis infection of mice any further. In turn, a reduction of the cell-permeabilizing activity of CyaA did not reduce B. pertussis virulence any importantly. These results suggest that the phagocyte-paralyzing cAMP-elevating capacity of CyaA prevails over the cell-permeabilizing activity of CyaA that appears to play an auxiliary role in the biological activity of the CyaA toxin in the course of B. pertussis infections in vivo.