Miracle-dz/UniFAR-FTUs huggingface dataset:
A novel germline mutation of the PALB gene in a young Yakut breast cancer woman

Background. Breast cancer (BC) is the most common female malignancy worldwide. partner and localizer of BRCA2 gene (PALB2) is directly involved in DNA damage response. germline mutation in PALB2 has been identified in breast cancer and familial pancreatic cancer cases, accounting for approximately 1–2% and 3–4%, respectively. the goal of this report was to describe new PALB2 mutation in a young Yakut breast cancer patient with family history of cancer. Material and methods. Genomic DNA were isolated from blood samples and used to prepare libraries using a capture-based target enrichment kit, Hereditary Cancer Solution™ (SOPHIA GENETICS, Switzerland), covering 27 genes (ATM, APC, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, FAM175A, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, PALB2, PIK3CA, PMS2, PMS2CL, PTEN, RAD50, RAD51C, RAD51D, STK11, TP53 and XRCC2). paired-end sequencing (2 × 150 bp) was conducted using NextSeq 500 system (Illumina, USA). Results. Here we describe a case of a never-before-reported mutation in the PALB gene that led to the early onset breast cancer. We report the case of a 39-year-old breast cancer Yakut woman with a family history of pancreatic cancer. Bioinformatics analysis of the NGS data revealed the presence of the new PALB2 gene germinal frameshift deletion (NM_024675:exon1:c.47dela:p.K16fs). in accordance with dbPubMed ClinVar, new mutation is located in codon of the PALB2 gene, where the likely pathogenic donor splice site mutation (NM_024675.3:c.48+1delG) associated with hereditary cancer-predisposing syndrome has been earlier described. Conclusion. We found a new never-before-reported mutation in PALB2 gene, which probably associated with early onset breast cancer in Yakut indigenous women with a family history of pancreatic cancer.
A Comparative Study of Case-Based Learning vs. Traditional Teaching Method in Pathology in Indian Medical Graduates

Background: There has been a substantial shift in the educational curriculum in Indian medical institutes with a more experiential approach toward teaching. One such method is case-based learning (CBL). Objectives: This study aimed to compare CBL with traditional method and gain students’ and teachers’ feedback. Methods: This was a cross-sectional study conducted in the Pathology Department among second-year bachelor of medicine and bachelor of surgery (MBBS) students. The students were divided into two groups of 75 students: group A was given anemia cases, and group B was given jaundice cases. After covering theory lectures on these topics, the students were given pre-test multiple-choice questions (MCQs). This was followed by this was followed by subdividing students into five groups and conducting three CBL sessions. This was followed by post-CBL test. Data were compared using paired t-test and analyzed using SPSS software version 16. Results: Out of 150, 110 students attended the pre-and post-CBL test and completed the feedback form. There was a significant improvement (P < 0.001) in the mean scores of students in both groups A and B from 8.31 and 7.54 to 13.44 and 12.71, respectively. Regarding the student feedback, it was revealed that 87% of the students agreed with the usefulness of CBL in better understanding of the topic and retention in memory. They also acclaimed that it encouraged their critical thinking and decision-making qualities. Among the faculties, all of them agreed with the incorporation of CBL in the routine curriculum. Conclusions: CBL improves students’ logical, analytical and clinical skills, which helps bridge the gap between theoretical knowledge and clinical skills. Rather than replacing, it serves better as an adjunct to the traditional lectures.
Adjusting for 30-hour undigested neutral detergent fiber in substitution of wheat straw and beet pulp for alfalfa hay and corn silage in the dairy cow diet: Chewing activities, diurnal feed intake, and ruminal fermentation

Graphical Abstract Summary: Feeding behavior and ruminal fermentation characteristics of lactating cows were investigated when offered rations supplying similar forage undigested neutral detergent fiber (NDF) and dietary NDF digestibility (both measured after 30 hours of in situ incubation). Diets contained wheat straw (WS) and beet pulp (BP), which replaced corn silage and alfalfa hay. Time spent eating decreased linearly and rumination activity remained unaffected as the proportion of WS and BP increased. This resulted in a linear reduction in chewing behavior.
Sorghum Grain Quality as Affected by Different Nitrogen Fertilizer Sources, Cultivar and Field Condition

The source of nitrogen fertilizer applied in the soil during the development of sorghum can affect the grain quality. The objective of this study was to determine the quality of sorghum grains as influenced by different nitrogen fertilizer sources and field conditions. The experiment used incorporated a 2x5x2 factorial arranged in a split-split plot design that was fitted into a randomized complete block design. Sorghum grain samples were analyzed for ash, fiber, fat, protein, and starch contents in percentages by using a Near-infrared spectroscopy machine. Nitrogen fertilizer source and had a significant effect on sorghum crude protein content during the 2018/19 planting season. The study indicated that nitrogen fertilizer sources such as limestone ammonium nitrate and urea are suitable for improving the quality of the sorghum grain. For example, limestone ammonium nitrate significantly improved the quality of the sorghum grain since it affected protein and starch content. Urea was also found to play a significant role in the grain quality as it affected the fiber and starch content of the grain. Field conditions had a significant effect on sorghum crude fiber and protein during the 2019/20 planting season. The increase in crude fiber under dryland field conditions proves that the quality of sorghum can be increased under no supplementary irrigation. This study, therefore, indicates that sorghum grain quality is influenced by the type of cultivar, the nitrogen fertilizer source, and the field conditions.
Efficient exact algorithms for continuous bi‐objective performance‐energy optimization of applications with linear energy and monotonically increasing performance profiles on heterogeneous high performance computing platforms

Performance and energy are the two most important objectives for optimization on heterogeneous high performance computing platforms. This work studies a mathematical problem motivated by the bi‐objective optimization of data‐parallel applications on such platforms for performance and energy. First, we formulate the problem and present an exact algorithm of polynomial complexity solving the problem where all the application profiles of objective type one are continuous and strictly increasing, and all the application profiles of objective type two are linear increasing. We then apply the algorithm to develop solutions for two related optimization problems of parallel applications on heterogeneous hybrid platforms, one for performance and dynamic energy and the other for performance and total energy. Our proposed solution methods are then employed to solve the two bi‐objective optimization problems for two data‐parallel applications, matrix multiplication and gene sequencing, on a hybrid platform employing five heterogeneous processors, namely, two different Intel multicore CPUs, an Nvidia K40c GPU, an Nvidia P100 PCIe GPU, and an Intel Xeon Phi.
A generalization of the Leeson effect

The oscillator, inherently, turns the phase noise of its internal components into frequency noise, which results into a multiplication by 1/f^2 in the phase-noise power spectral density. This phenomenon is known as the Leeson effect. This report extends the Leeson effect to the analysis of amplitude noise. This is done by analyzing the slow-varying complex envelope, after freezing the carrier. In the case of amplitude noise, the classical analysis based on the frequency-domain transfer function is possible only after solving and linearizing the complete differential equation that describes the oscillator. The theory predicts that AM noise gives an additional contribution to phase noise. Beside the detailed description of the traditional oscillator, based on the resonator governed by a second-order differential equation (microwave cavity, quartz oscillators etc.), this report is a theoretical framework for the analysis of other oscillators, like for example the masers, lasers, and opto-electronic oscillators. This manuscript is intended as a standalone report, and also as complement to the book E. Rubiola, Phase Noise and Frequency Stability in Oscillators, Cambridge University Press, 2008. ISBN 978-0-521-88677-2 (hardback), 978-0-521-15328-7 (paperback).
Robust secure synchronization control for multiple neural networks: An event‐triggered adaptive integral sliding mode method

This article investigates the robust secure synchronization control of multiple neural networks (MNNs) systems with external random disturbances in the presence of actuator and sensor attacks. First, the types of attacks are analyzed in detail. Actuator attacks refers to the damage of control input signals transmitted through the network layer, and sensor attacks refers to the damage of communication channels between neural networks (NNs). Then, for the attacked NNs system, by introducing a novel neighborhood synchronization error, two novel integral sliding mode (ISM) functions with the event‐triggered mechanisms are designed. Based on this, a distributed event‐triggered adaptive ISM secure synchronization control scheme is proposed. It is worth noting that the control signal and adaptive parameters in the proposed scheme are only updated at the triggering time instants, which further saves the energy and resources consumed by the system. Next, the sufficient conditions for secure synchronization of MNNs system are obtained by constructing Lyapunov function and a positive lower bound of the internal execution time is ensured. Finally, a numerical example is given to demonstrate the effectiveness of the proposed secure synchronization control strategy.
A Personal List of Unsolved Problems Concerning Lattice Gases and Antiferromagnetic Potts Models

I review recent results and unsolved problems concerning the hard-core lattice gas and the q-coloring model (antiferromagnetic Potts model at zero temperature). For each model, I consider its equilibrium properties (uniqueness/nonuniqueness of the infinite-volume Gibbs measure, complex zeros of the partition function) and the dynamics of local and nonlocal Monte Carlo algorithms (ergodicity, rapid mixing, mixing at complex fugacity). These problems touch on mathematical physics, probability, combinatorics and theoretical computer science.
Calibration of seven-hole pressure probes for use in fluid flows with large angularity

Described here is the calibration of a non-nulling, conical, seven-hole pressure probe over a large range of flow onset angles. The calibration procedure is based on the use of differential pressures to determine the three components of velocity. The method allows determination of the flow angle to within 0.5 deg and velocity magnitude to approximately 1.0 percent. Also included is an examination of the factors which limit the use of the probe, a description of the measurement chain, an error analysis, and a typical experimental result. In addition, a new general analytical model of pressure probe behavior is described and the validity of the model is demonstrated by comparing it with experimentally measured calibration data for a three-hole yaw meter and a seven-hole probe.
Linear Regression and ARIMA Models for Electricity Demand Forecasting in West Africa

This article focuses on the predictive study of electricity demand in West African countries based on the multivariate linear regression model and the ARIMA model. The objective of the study is first to establish for each country a linear regression model and ARIMA model, then to compare the two (2) models based on the MAD, RMSE and MAPE coefficients, and finally to deduce of this comparison the best valid model to establish the electricity demand prediction of the country. We have come to the conclusion that the ARIMA model is more adequate for predicting the electricity demand of most of West African countries with the exception of Gambia, Ghana, Guinea, Liberia and Nigeria where the multivariate linear regression model performs better.
Evaluation of Discharged Untreated Wastewater from Pulping and Bleaching Operations in a Bamboo Based Tissue Paper Making Plant in Nigeria

This study on Evaluation of Discharged Untreated Wastewater from Pulping and Bleaching operations in a Bamboo Based tissue Paper Making Plant in Nigeria was conducted mainly to evaluate the pollutant loads present in wastewater produced during the Pulping and Bleaching operations of the tissue paper making progression. The wastewater samples were obtained and examined to find out the pollutants they contain by checking the availability of some physicochemical parameters using standard methods by American Public Health Association (APHA). The analyzed parameters obtained for the pulping and bleaching processes respectively are pH (7.42 and 4.49), EC (316µS/cm and 47µS/cm), TDS (158mg/l and 24mg/l), Turbidity (19.3NTU and 28.7NTU), Temperature (28.47°C and 28.48°C), DO (3.66mg/l and 1.93mg/l), BOD5 (74.02mg/l and 62.00mg/l), COD (140.30mg/l and 120.40mg/l), TOC (10.3% and 7.1%), THB (1.60x103cfu/ml and 7.40x104cfu/ml), THF (0cfu/ml and 2.30x103cfu/ml) and heavy metals like Hg (<0.001mg/l and <0.001mg/l), Pb (0.281mg/l and 0.273mg/l), Ni (0.115mg/l and 0.117mg/l), Co (0.193mg/l and 0.208mg/l) and As (<0.001mg/l and <0.001mg/l). These results were also compared amid the permissible regulatory standards set by the FMEnv and NESREA. From the comparative analysis, the bleaching wastewater sample was more polluted than that from pulping. EC, TDS, BOD5, COD, TOC and Pb were higher in the pulping wastewater sample which could be attributed to the organic nature of the starting material; bamboo and residues of the pulping agents; caustic soda and ammonia while Acidity, Turbidity, Temperature, DO, Ni, Co, THB and TF were higher in the bleaching wastewater sample and could be caused by the bleaching agents and the availability of microorganisms. The result showed that some parameters except BOD5, turbidity, COD, DO and pH from pulping fell within regulatory limit. This could be linked to the virgin fibre from bamboo applied which contains less pollutant compared to other industries using waste papers from different sources.
Word-level asymmetries in consonant articulation

A variety of studies have shown articulatory asymmetries between consonants which are initial vs. final in their syllable and/or word; however, the asymmetry is not always found and its nature is not clear. In this paper we investigate some factors that might seem to make the asymmetry less than universal, using dynamic electropalatography. First, we considered a range of consonants, to see whether only some classes of consonants show the asymmetry, and found it for the non-sibilant non-continuants /t/ /d/ /k/ /n/ and /l/, but not for sibilant fricatives, though all consonants showed an asymmetry in acoustic duration. Second, we considered how the wordlevel asymmetry interacts with phrase-level effects on articulation, and found that it can be countered by an independent effect of final position in utterance. Third, a pilot study considered whether a word-level asymmetry can be distinguished from a syllable-level asymmetry, but no systematic or consistent differences were found.
Electromagnetic Weibel instability in intense charged particle beams with large energy anisotropy

In plasmas with strongly anisotropic distribution functions, collective instabilities may develop if there is sufficient coupling between the transverse and longitudinal degrees of freedom. Our previous numerical and theoretical studies of intense charged particle beams with large temperature anisotropy [E. A. Startsev, R. C. Davidson, and H. Qin, Phys. Rev. ST Accel. Beams 6, 084401 (2003); Phys. Plasmas 9, 3138 (2002)] demonstrated that a fast, electrostatic, Harris-type instability develops, and saturates nonlinearly, for sufficiently large temperature anisotropy (T⊥b/T∥b≫1). The total distribution function after saturation, however, is still far from equipartitioned. In this paper the linearized Vlasov–Maxwell equations are used to investigate detailed properties of the transverse electromagnetic Weibel-type instability for a long charge bunch propagating through a cylindrical pipe of radius rw. The kinetic stability analysis is carried out for azimuthally symmetric perturbations about a two-temperatu.
Everywhere of Second Category Sets

The main result of this paper states the following. For each natural number i, let G i be a proper additive subgroup of the reals, A i a set that contains no arithmetic progression of length three, H i a basis for the vector space R over the ﬁeld of rationals, and E + ( H i ) the set of all ﬁnite linear combinations from the elements of H i with nonnegative rational coeﬃcients. Then the complement of a ﬁnite union of sets G i ∪ A i ∪ E + ( H i ) is everywhere of second category. We also prove that the complement of a union of fewer than continuum many translates of sets that have distinct distances is everywhere of second category.
Human Morality Is Based on an Early-Emerging Moral Core

Scholars from across the social sciences, biological sciences, and humanities have long emphasized the role of human morality in supporting cooperation. How does morality arise in human development? One possibility is that morality is acquired through years of socialization and active learning. Alternatively, morality is instead based on a “moral core”: primitive abilities that emerge in infancy to make sense of morally relevant behaviors. Here, we review evidence that infants and toddlers understand a variety of morally relevant behaviors and readily evaluate agents who engage in them. These abilities appear to be rooted in the goals and intentions driving agents’ morally relevant behaviors and are sensitive to group membership. This evidence is consistent with a moral core, which may support later social and moral development and ultimately be leveraged for human cooperation. Expected final online publication date for the Annual Review of Developmental Psychology, Volume 4 is December 2022. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Paradigm Shift in Materials for Skull Reconstruction Facilitated by Science and Technological Integration

The surgical repair of a bone deficiency in the skull caused by a prior procedure or accident is known as cranioplasty. There are various types of cranioplasties, but the majority entail raising the scalp and reshaping the skull using either the original piece of bone from the skull or a specially molded graft created from Titanium (plate or mesh), artificial bone in place of, a stable biomaterial (prefabricated customized implant to match the exact contour and shape of the skull). Cranioplasty, one of the oldest surgical treatments for cranial abnormalities, has undergone several changes throughout the years to discover the best material to improve patient outcomes. Various materials have been utilized in cranioplasty throughout history. As biomedical technology progresses, surgeons will have access to new materials. There is still no agreement on the optimum material, and research into biologic and nonbiologic alternatives is ongoing in the hopes of finding the finest reconstruction material. The materials and techniques used in cranioplasty are covered in this article.
Characteristics of the Poynting flux and wave normal vectors of whistler‐mode waves observed on THEMIS

The characteristics of the Poynting flux and wave normal vectors of whistler‐mode waves outside the plasmapause are investigated for the lower (0.1–0.5 fce) and upper bands (0.5–0.8 fce), where fce is the equatorial electron cyclotron frequency. To analyze the wave properties, we utilized high‐resolution waveform data from multiple THEMIS spacecraft in the near‐equatorial magnetosphere from June 2008 to November 2012. Full measurements of the wave electric and magnetic fields are used to calculate the Poynting fluxes and construct the wave normal vectors, which are then used to calculate the polar and azimuthal angles with respect to the background magnetic field. Statistical results show that the majority of whistler‐mode waves propagate away from the magnetic equator, suggesting that the major source region is very close to the equator. The lower band wave normal angle distribution shows a major peak close to the field line direction and a secondary peak near the resonance cone. In contrast, the wave normal distribution of upper band waves exhibits a broad distribution between 0° and 60° with the largest probability at ~0°. The azimuthal component of the wave normal vector predominantly points radially outward for both lower and upper band waves, but a tendency for azimuthal propagation is observed for lower band waves in the day and dusk sectors probably due to pronounced azimuthal density gradients in the afternoon sector. Our statistical results provide crucial information on the Poynting fluxes and wave normal vectors of whistler‐mode waves, which play a significant role in radiation belt electron dynamics.
Effect of Hours of Exposure to Cement Dust on Cancers Markers on Cement Workers in Port Harcourt

The study was aimed at evaluating the effect of cement dust exposure on cement loaders in Port Harcourt. The study was a cross sectional study which used convenient sampling size of 100 healthy male cement workers recruited in one cement depot and eight cement loading sites in Port Harcourt using simple random technique. Subjects were classified into three groups based on daily hour cement exposure; group 1 (1-5 hrs), group 2 (6-10 hrs) and group 3 (>10 hrs). Group 1 had 27 subjects, group 2 had 62 subjects and group 3 had 11 subjects. 4 ml of the venous blood was drawn into plain vacutainer bottles for the evaluation of Neuron specific Enolase, Vascular Endothelial Growth Factor A, and Total Antioxidant Status. ELISA method was used for the laboratory determination of VEGF-A and NSE while a colorimetric method was used for TAS estimation. Results showed TAS level among the classes was not significantly different (p=0.3304) and has the mean value of 2.02±0.40; 2.16±0.41 and 2.1 ±0.41 in groups 1, 2 and 3 respectively. VEGF-A level among the classes was not significantly different (p=0.7123) with mean value of 406.00 ±234.80; 439.60 ±369.40 and 361.00 ±171.00 in groups 1, 2 and 3 respectively. The mean value for NSE level among the groups (1, 2, and 3) were 3.78±1.49; 4.17±2.91 and 3.42±0.98 but there was no significantly difference (p=0.5551). This has shown that hourly exposure to cement dust among healthy cement workers does not have significant impact on cancer markers (VEGF-A, NSE and TAS). A higher timeframe assessment may provide a better picture of the effect of cement dust exposure since many diseases associated with cement dust exposure are chronic.