Miracle-dz/UniFAR-FTUs huggingface dataset:
Modulating the Mechanical Resonance of Huh-7 Cells Based on Elasticity of Adhesion Proteins

The atomic force microscope (AFM) has been used in cell biology for a decade. AFM is a unique tool for investigating the viscoelastic characteristics of live cells in culture and mapping the spatial distribution of mechanical properties, giving an indirect signal of the underlying cytoskeleton and cell organelles. Although several experimental and numerical studies were conducted to analyze the mechanical properties of the cells. We established the non-invasive Position Sensing Device (PSD) technique to evaluate the resonance behavior of the Huh-7 cells. This technique results in the natural frequency of the cells. Obtained experimental frequencies were compared with the numerical AFM modeling. Most of the numerical analysis were based on the assumed shape and geometry. In this study, we propose a new method for numerical AFM characterization of Huh-7 cells to estimate its mechanical behavior. We capture the actual image and geometry of the trypsinized Huh-7 cells. These real images are then used for numerical modeling. The natural frequency of the cells was evaluated and found to be in the range of 24 kHz. Furthermore, the impact of focal adhesion (FA’s) stiffness on the fundamental frequency of the Huh-7 cells was investigated. There has been a 6.5 times increase in the natural frequency of the Huh-7 cells on increasing the FA’s stiffness from 5 pN/nm to 500 pN/nm. This indicates that the mechanical behavior of FA’s leads to change the resonance behavior of the Huh-7 cell. Hence FA’s are the key element in controlling the dynamics of the cell. These measurements can enhance our understanding of normal and pathological cell mechanics and potentially improve disease etiology, diagnosis, and therapy choices. The proposed technique and numerical approach are further useful in selecting the target therapies parameters (frequency) and evaluating of mechanical properties of the cells.
Multi-Level Fusion Indoor Positioning Technology Considering Credible Evaluation Analysis

Aiming at the problems of the low robustness and poor reliability of a single positioning source in complex indoor environments, a multi-level fusion indoor positioning technology considering credible evaluation is proposed. A multi-dimensional electromagnetic atlas including pseudolites (PL), Wi-Fi and a geomagnetic field is constructed, and the unsupervised learning model is used to sample in the latent space to achieve a feature-level fusion positioning. A location credibility evaluation method is designed to improve the credibility of the positioning system through a multi-dimensional data quality evaluation and heterogeneous information auxiliary constraints. Finally, a large number of experiments were carried out in the laboratory environment, and, finally, about 90% of the positioning error was better than 1 m, and the average positioning error was 0.56 m. Compared with several relatively advanced positioning methods (Inter-satellite CPDM/Epoch-CPDS/Z-KPI) at present, the average positioning accuracy is improved by about 56%, 83.5% and 82.9%, respectively, which verifies the effectiveness of the algorithm. To verify the effect of the proposed method in a practical application environment, the proposed positioning system is deployed in the 2022 Winter Olympics venues. The results show that the proposed method has a significant improvement in the positioning accuracy and continuity.
Characteristics of Parental Digital Mediation: Predictors, Strategies, and Differences among Children Experiencing Various Parental Mediation Strategies

The process of digitalization has become an integral part of the social situation of a child’s growth in the modern world. Child development in the digital environment demands the involvement of adults as mediators. This practice is called parental digital mediation. Previous studies have identified the significant parental and environmental aspects of parental mediation, but there has been little information about the relationships between the children’s characteristics and parental digital mediation. The current study aims to fill this gap by identifying the behavioral (social network and screen time) and emotional (social network addiction and happiness) predictors of the two dimensions of digital mediation: parental support and parental control. The study also examines the differences among children influenced by various parental mediation strategies. A total of 4011 students (42% male and 58% female) ranging in age from 13 to 15 years (M = 14.07; SD = 0.76) took part in the study. The parental mediation of their children’s internet use, social media addiction, social network time, screen time, and happiness were measured. According to the results, both the behavioral and emotional characteristics of the children served as predictors of parental mediation. A small amount of time spent on social networks or screens and low social media addiction and happiness were identified as the predictors of parental support, whereas a large amount of time spent on social networks and screens and low social media addiction were identified as the predictors of parental control. Three groups of children experiencing different parental mediation strategies were determined. The children with parents who enabled mediation were happier than the others. Children under instructive mediation demonstrated the highest tendency to social media addiction. Children under selective mediation spent the most time (of all groups) on gadgets, but they showed a low tendency towards social media addiction.
The ACT Predicts Academic Performance—But Why?

Scores on the ACT college entrance exam predict college grades to a statistically and practically significant degree, but what explains this predictive validity? The most obvious possibility is general intelligence—or psychometric “g”. However, inconsistent with this hypothesis, even when independent measures of g are statistically controlled, ACT scores still positively predict college grades. Here, in a study of 182 students enrolled in two Introductory Psychology courses, we tested whether pre-course knowledge, motivation, interest, and/or personality characteristics such as grit and self-control could explain the relationship between ACT and course performance after controlling for g. Surprisingly, none could. We speculate about what other factors might explain the robust relationship between ACT scores and academic performance.
Probing system size dependence at high baryon density by systematic comparison of Ag+Ag and Au+Au reactions at 1.23A GeV

We present UrQMD predictions for the comparison of the recently measured Ag+Ag and Au+Au runs at a beam energy of $E_\mathrm{lab}$ = 1.23~$A$GeV explored by the HADES experiment. To this aim, different centrality definitions are investigated: We suggest that in the case of particle production, both systems should be compared at the same number of participating nucleons, while for a comparison of the (elliptic) flow, a selection on the initial state eccentricity - as in high energy reactions - is better suited. Generally, we find good agreement between both systems, if these centrality criteria are used. Specifically, the deuteron yields per participant and the pion to proton ratios are shown to scale with $A_\mathrm{part}$ except for very central Ag+Ag reactions due to stronger stopping in such reactions. The elliptic flow in both systems follows initial state eccentricity scaling, albeit with the opposite sign as compared to high energies, suggesting a strong relation between final flows and the initial state also at the low energies explored here. The observation of this scaling might then allow to obtain further information on the expansion properties (and the EoS) of matter at high baryon densities.
ULF electromagnetic turbulence in the high-latitude topside ionosphere

Results obtained by the Aureol 3 satellite on electromagnetic waves in the ELF range in the high-latitude yopside ionosphere show the existence of a new type of turbulence. This turbulence is observed on both the electric and magnetic wave components and appears as bursts of 0.1 s to a few seconds typical duration in the polar cusp and auroral zone, associated with field-aligned currents and low energy electron precipitations. The two possible interpretations of these observatons, either in terms of a filamentary structure of the field-aligned currents or of Alfven waves are discussed. For either of these models the observed values of the parallel component of the electric field are much larger than those predicted by classical models of the electrodynamics of the lower ionosphere. These results are compared with recent observations and might indicate the existence of acceleration mechanisms at low altitudes.
A Mechanism Exploration for the Yi-Fei-San-Jie Formula against Non-Small-Cell Lung Cancer Based on UPLC-MS/MS, Network Pharmacology, and In Silico Verification

Non-small-cell lung cancer (NSCLC) is one of the most prevalent cancers worldwide. A Yi-Fei-San-Jie formula (YFSJF), widely used in NSCLC treatment in south China, has been validated in clinical studies. However, the pharmacological mechanism behind it remains unclear. In this study, 73 compounds were identified using ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), with 58 enrolled in network pharmacology. The protein-protein interaction network, functional enrichment analysis, and compound-target-pathway network were constructed using 74 overlapping targets from 58 drugs and NSCLC. YFSJF has many targets and pathways in the fight against NSCLC. PIK3R1, PIK3CA, and AKT1 were identified as key targets, and the PI3K/AKT pathway was identified as the key pathway. According to the Human Protein Atlas (THPA) database and the Kaplan–Meier Online website, the three key targets had varying expression levels in normal and abnormal tissues and were linked to prognosis. Molecular docking and dynamics simulations verified that hub compounds have a strong affinity with three critical targets. This study revealed multiple compounds, targets, and pathways for YFSJF against NSCLC and suggested that YFSJF might inhibit PIK3R1, PIK3CA, and AKT1 to suppress the PI3K/AKT pathway and play its pharmacological role.
2022 EUROPEAN SUMMER MEETING OF THE ASSOCIATION FOR SYMBOLIC LOGIC LOGIC COLLOQUIUM 2022 Reykjavík University Reykjavík, Iceland June 27 – July 1, 2022

Logicbecame“formal”attheendofthe19thcenturyprimarilyinpursuitofdeductiverigor within mathematics. But by the early 20th century, a formal treatment of logic had become essential to two new streams in the current of logic: the collection of crucial “semantic” notions surrounding the idea of categoricity
Fractionation of CO in the diffuse clouds toward Zeta Ophiuchi

An analysis of CO A-X bands in diffuse clouds toward Zeta Ophiuchi is presented. The results provide isotopic ratios that constitute the strongest observational evidence for highly localized isotopic fractionation of CO in diffuse portions of an interstellar cloud. The value of the fractionation implies that selective photodissociation is the controlling influence of the fractionation. The molecule's excitation temperature is discussed and a lower limit to the O-16/O-18 ratio is provided. The absence of CO lines from the gas that provides broad CH+ and CH lines commonly attributed to warm gas behind a shock front is addressed.
Collocation Trefftz Method for the Heat Conduction Issue in Irregular Domain

Rules for non-orthogonal borders of irregular domain is the thorny issues when using analytical method for solving mathematical and physical equations. On the basis of solution in the form of separated variables, the border of arbitrary shape with non-orthogonal boundary will be separated into a limited number of discrete points, and then direct assignment for the form solution at each of the discrete points on the border according to boundary conditions, at every discrete points on the border can establish an equation. If the number of discrete points on the border is the same with truncated series after retained series, all coefficients of the form solution can be determined and the problem solved. This paper use Laplace equation as an example to illustrate Collocation Trefftz Method can solve certain steady-state heat conduction problems within non-orthogonal border and irregular domain.
Inertial transfers in the helical decomposition

The directions of the triadic energy transfers assumed in a previous paper [Phys. Fluids A 4, 350 (1992)] agree with the spectral closures, in a similarity range, if the exponent of the power‐law energy spectrum is less than unity. The helical interactions showing a strong local energy transfer when the triad is nonlocal, sum up to a reverse cascade unless the spectrum falls off faster than a −7/3 power of the wave number. The energy cascades from each type of helical interaction are calculated for a −5/3 inertial range using the eddy damped quasinormal Markovian (EDQNM) model. One type of interaction is responsible for 86% of the cascade. The contributions of the two classes of helical interactions to the subgrid‐scale eddy viscosity are presented, together with the contributions from the forward and reverse cascading interactions. An application of the assumption on the triadic energy transfers to turbulence under rapid rotation gives a simple argument for the tendency toward nonlinear two‐dimensionaliz.
Regioselective Bay-Functionalization of Perylenes Toward Tailor-Made Synthesis of Acceptor Materials for Organic Photovoltaics.

Development of an efficient synthetic protocol for multiply bay-functionalized perylenes and application of the synthetic product to photovoltaics have been disclosed. Tetrabenzyl 1-(4-tert-butylphenoxy)perylene-3,4,9,10-tetracarboxylate underwent a regioselective bromination at 7-position followed by a further bromination at 12-position to provide a 7,12-dibromide in high yield. This compound was transformed into a tetrasubstituted C2h-symmetric dibromide by a controlled mono-etherification and a final bromination. Synthetic versatility of the new brominated precursors was demonstrated byapplying them to cross-coupling reaction, cyanation, and derivatization to the corresponding perylene diimide (PDI). Owing to the high solubility and the lifted LUMO level, the obtained tetrasubstituted PDI gave significant advantages as an acceptor material for photovoltaic application exhibiting remarkably high open-circuit voltage (VOC) reaching 1.00 V. The observed high VOC could be understood by reduction of energy offset for charge separation and non-radiative recombination loss.
Convergence of Jump-Diffusion Modelsto the Black–Scholes Model

We consider a jump-diffusion model for asset price which is described as a solution of a linear stochastic differential equation driven by a Lévy process. Such a market is incomplete and there are many equivalent martingale measures. We price a contingent claim with respect to the minimal martingale measure and construct a hedging strategy for the contingent claim in the locally risk-minimizing sense. We study the problem of convergence of option prices jointly with the costs from the locally risk-minimizing strategies when the jump-diffusion models converge to the Black–Scholes model.
Design of a Magnetic Soft Inchworm Millirobot Based on Pre-Strained Elastomer with Micropillars

Rather than using longitudinal “muscle” as in biological inchworm, the existing magnetic active elastomer (MAE)-based inchworm robots utilize magnetic torque to pull and push the soft body, which hinders its locomotion mobility. In this paper, a new pre-strained MAE inchworm millirobot with micropillars is proposed. The pre-strained elastomer serves as a pre-load muscle to contract the soft body, and the micropillars act as tiny feet to anchor the body during the locomotion. The proposed magnetic inchworm robot features a simple fabrication process that does not require special magnetization equipment. For the first time, the pre-load muscle is introduced in the design of magnetic inchworm robots, making it more like a real inchworm in terms of locomotion mechanism. The locomotion principle and parametric design for the desired locomotion performance have been investigated. Experimental results show that the fabricated magnetic inchworm robot (size: 10 mm × 5 mm, micropillars length: 200 µm, and mass: 262 g) can locomote on a smooth acrylic surface (roughness of 0.3 µm) at the speed of 0.125 body lengths per second, which is comparable with the existing magnetic inchworm robots. Moreover, the locomotion capabilities of the inchworm robot on wet surfaces and inclined planes have been verified via experimental studies.
The Characterization of Multiple Harmanic Riesz Bases of Affine Subspaces and Applications

An information system is any combination of information technology and people's act- ivities that support operations, management and decision making. Information science focuses on understanding problems from the perspective of the stakeholders involved and then applying information and other technologies as needed. The definition of multiple harmonic frames for subs -paces with integer translation is proposed. The notion of a generalized multiresolution structure of is also introduced. The construction of a generalized multiresolution structure of Paley -Wiener subspaces of is investigated. The pyramid decomposition scheme is derived based on a generalized multiresolution structure.
Biofilms in Chronic Wound Infections: Innovative Antimicrobial Approaches Using the In Vitro Lubbock Chronic Wound Biofilm Model

Chronic wounds have harmful effects on both patients and healthcare systems. Wound chronicity is attributed to an impaired healing process due to several host and local factors that affect healing pathways. The resulting ulcers contain a wide variety of microorganisms that are mostly resistant to antimicrobials and possess the ability to form mono/poly-microbial biofilms. The search for new, effective and safe compounds to handle chronic wounds has come a long way throughout the history of medicine, which has included several studies and trials of conventional treatments. Treatments focus on fighting the microbial colonization that develops in the wound by multidrug resistant pathogens. The development of molecular medicine, especially in antibacterial agents, needs an in vitro model similar to the in vivo chronic wound environment to evaluate the efficacy of antimicrobial agents. The Lubbock chronic wound biofilm (LCWB) model is an in vitro model developed to mimic the pathogen colonization and the biofilm formation of a real chronic wound, and it is suitable to screen the antibacterial activity of innovative compounds. In this review, we focused on the characteristics of chronic wound biofilms and the contribution of the LCWB model both to the study of wound poly-microbial biofilms and as a model for novel treatment strategies.
Considerations on the protection of teleworkers, in light of the current
European regulations. Elements of comparative law

The proliferation of the teleworking phenomenon entails a number of aspects, such as the organization of working time or the work safety and health of teleworkers, which are not fully covered by the current legislation. This puts teleworkers at an increased risk of being treated less favorably than regular workers and implicitly calls for additional protective measures for teleworkers. Consequently, the present paper offers an overview of the main legislative documents adopted by the European Union, which concern teleworkers directly or indirectly, in order to ascertain the extent to which the current legislative standards meet the specific needs of the teleworkers. Also relevant for this aim is the comparative law analysis which demonstrates how some states of the European Union have increased their efforts to amend their legal systems, in order to eliminate the discriminatory practices detrimental to teleworkers and to enhance the protection they enjoy. The study presents the different legislative perspectives of Germany, France, Spain, Italy.
Method for Optimally Controlling Unsteady Shock Strength in One Dimension

This paper presents a new formulation and computational solution of an optimal control problem concerning unsteady shock wave attenuation. The adjoint system of equations for the unsteady Euler system in one dimension is derived and used in an adjoint-based solution procedure for the optimal control. A novel algorithm is used to satisfy all necessary first-order optimality conditions while locally minimizing an appropriate cost functional. Distributed control solutions with certain physical constraints are calculated for attenuating blast waves similar to those generated by ignition overpressure from the shuttle’s solid rocket booster during launch. Results are presented for attenuating shocks traveling at Mach 1.5 and 3.5 down to 85%, 80%, and 75% of the uncontrolled wave’s driving pressure. The control solutions give insight into the magnitude and location of energy dissipation necessary to decrease a given blast wave’s overpressure to a set target level over a given spatial domain while using only as m.
Initial reaction of hafnium oxide deposited by remote plasma atomic layer deposition method

A remote plasma atomic layer deposition (RPALD) method has been applied to grow a hafnium oxide thin film on the Si substrate. The deposition process was monitored by in situ XPS and the as-deposited structure and chemical bonding were examined by TEM and XPS. The in situ XPS measurement showed the presence of a hafnium silicate phase at the initial stage of the RPALD process up to the 20th cycle and indicated that no hafnium silicide was formed. The initial hafnium silicate was amorphous and grew to a thickness of approximately 2nm. Based on these results and model reactions for silicate formation, we proposed an initial growth mechanism that includes adatom migration at nascent step edges. Density functional theory calculations on model compounds indicate that the hafnium silicate is thermodynamically favored over the hafnium silicide by as much as 250kJ∕mol.
Genetically engineered bacterial‐like particles induced specific cellular and humoral immunity as effective tick‐borne encephalitis virus vaccine

Tick‐borne encephalitis (TBE) is a natural focal disease with fatal encephalitis induced by tick‐borne encephalitis virus (TBEV), seriously threatening human and public health. Protection of TBE depends on vaccination with inactivated vaccine, which requires high cost and multiple immunizations. Here, we construct genetically engineered bacterial‐like particles (BLPs) as an effective TBEV vaccine with simplified immunizations and improved immune efficacy. The TBEV BLPs involve the combination of the gram‐positive enhancer matrix from Lactococcus lactis, and TBEV envelope (E) protein expressed by genetically engineered recombinant baculovirus. The prepared TBEV BLPs can effectively stimulate the activation of dendritic cells to present the TBEV E proteins to T and B cells, leading to strong and durable cellular and humoral immune responses in mice. Surprisingly, the serum levels of specific IgG antibodies in mice remain about 106 at 6 months after the secondary immunization. Overall, the TBEV BLPs can be used as a potent vaccine candidate, laying the foundation for developing novel TBEV genetically engineered vaccines.