Miracle-dz/UniFAR-FTUs huggingface dataset:
MEGA: Microlensing Exploration of the Galaxy and Andromeda

Microlensing surveys have ruled-out that the dark halos of the Milky Way and M31 are composed entirely of massive compact halo objects (MACHOs) for a wide range of MACHO masses. We have tried using the Subaru telescope to improve the limit on Moon-mass MACHOs, which is the lowest decade in MACHO mass that can be probed by microlensing. Unfortunately, only a half-night of Subaru data was obtained and this is not enough; at least 2 nights of data are required. The current limit is based on nearly 6 years of observations with smaller telescopes.
A General Algorithm for Local Error Control in the RKrGLm Method

Simulation of physical systems often requires the solution of a system of ordinary differential equations, in the form of an initial-value problem. Usually, a Runge-Kutta method is used to solve such a system numerically. Recently, we examined how the computational efficiency of a Runge-Kutta method could be improved through the mechanism of the RKrGLm algorithm, in the context of global error control via reintegration (Prentice, 2009). The RKrGLm method for solving the d-dimensional system
Imaging for Transcatheter Aortic Valve Replacement Sentence Summary Retrospectively ECG-gated CTA is the first-line modality for preprocedural annular sizing, as it enables direct planimetry and reference standard measurements for all required annular parameters for TAVR deployment. Summary of Liter

Aortic stenosis (AS) is the most frequent type of valvular heart disease in Europe and North America. It primarily presents as calcific AS in adults of advanced age (2%-7% of the population, >65 years old) [1]. Although aortic valve replacement (AVR) is a definitive therapy for patients who meet the criteria [2-5] for severe AS, 32% to 48% of those patients do not undergo conventional AVR due to their advanced age, comorbidities, or prohibitive surgical risk [6-8].
Mindfulness buffers the in ﬂ uence of stress on cue-induced craving for Internet among Chinese colleges with problematic Internet use

Background and aims: Stress is a common experience among college students with problematic Internet use, and it may exacerbate their cue-induced Internet craving. This study aimed to examine the influence of stress on cue-induced craving for the Internet among subjects with problematic Internet use and the buffering effect of mindfulness. Methods: Sixty-eight college students with problematic Internet use were assigned to groups with a 2 (stress vs. no-stress) 3 2 (high vs. low mindfulness) between-subject design. Results: It was deduced that stress could significantly enhance cue-induced craving for the Internet, and mindfulness could buffer this effect. Specifically, the effect of stress on cue-induced craving for the Internet was weaker among subjects with high mindfulness as compared to subjects with low mindfulness. Discussion and Conclusions: These findings contribute to understanding of the factors influencing problematic Internet use and how such factors interact. It also provides recommendations on how to prevent the progression of problematic Internet use and suggests possible interventions.
ANALYSIS OF KNOWLEDGE AND ATTITUDE OF MEDICAL STUDENTS TOWARDS HIV/AIDS PATIENTS IN PAKISTAN

: Introduction: In this contemporary era, Human Immunodeficiency (HIV) and the Acquired Immune Deficiency Syndrome (AIDS) is a most significant public health challenge. Objectives of the study: The main objective of the study is to analyze the knowledge and attitude of dental students towards HIV/AIDS patients in Pakistan. Material and methods: This survey analysis was conducted in Bahawal Victoria hospital, Bahawalpur during November 2018 to April 2019. The data was collected through a questionnaire. The study included a convenience sample comprising dental students of all basic and clinical year. All the questions were anonymous, participant’s voluntary took part in the study, and consent was taken from them and no incentive was given for completing the survey. The questionnaire was made up of four parts. The answer to each question about attitude was rated on a five-point Likert scale (strongly agree, agree, neutral, disagree, and strongly disagree). Results: Out of 200 students who were sent the survey, a total of one ninety-three completed the survey. Therefore, the respond rate was 96.5%. These participants were from first, second, third, final professional year and house officers. On question 1 (HIV is same as AIDS), majority of students have inadequate knowledge and were not aware of the fact that HIV is same as AIDS. Regarding question 2 (saliva act as a vehicle of transmission), students from all the professional years and house officers have enough knowledge that saliva can act as vehicle of transmission.
Sturm‐Liouville problem for stationary differential operator with nonlocal integral boundary condition

Abstract The Sturm‐Liouville problem with various types of nonlocal integral boundary conditions is considered in this paper. In the first part of paper we investigate Sturm‐Liouville problem with two cases of nonlocal integral boundary conditions. We prove general properties of the eigenfunctions and eigenvalues for such problem in the complex case. In the second part we investigate real eigenvalues case. The spectrum depends of these problems on boundary condition parameters is analyzed. Qualitative behaviour of all eigenvalues subject to nonlocal boundary condition parameters is described.
Binary Toxin Production in Clostridium difﬁcile Is Regulated by CdtR, a LytTR Family Response Regulator (cid:1)

Clostridium difﬁcile binary toxin (CDT) is an actin-speciﬁc ADP-ribosyltransferase that is produced by various C. difﬁcile isolates, including the “hypervirulent” NAP1/027 epidemic strains. In contrast to the two major toxins from C. difﬁcile , toxin A and toxin B, little is known about the role of CDT in virulence or how C. difﬁcile regulates its production. In this study we have shown that in addition to the cdtA and cdtB toxin structural genes, a functional cdt locus contains a third gene, here designated cdtR , which is predicted to encode a response regulator. By introducing functional binary toxin genes into cdtR (cid:1) and cdtR -negative strains of C. difﬁcile , it was established that the CdtR protein was required for optimal expression of binary toxin. Signif-icantly increased expression of functional binary toxin was observed in the presence of a functional cdtR gene; an internal deletion within cdtR resulted in a reduction in binary toxin production to basal levels. Strains that did not carry intact cdtAB genes or cdtAB pseudogenes also did not have cdtR , with the entire cdt locus, or CdtLoc, being replaced by a conserved 68-bp sequence. These studies have shown for the ﬁrst time that binary toxin production is subject to strict regulatory control by
Single Amino Acid Modiﬁcation of Adeno-Associated Virus Capsid Changes Transduction and Humoral Immune Proﬁles

Adeno-associated virus (AAV) vectors have the potential to promote long-term gene expression. Unfortunately, humoral immunity restricts patient treatment and in addition provides an obstacle to the potential option of vector readministration. In this study, we describe a comprehensive characterization of the neutralizing antibody (NAb) response to AAV type 1 (AAV1) through AAV5 both in vitro and in vivo . These results demonstrated that NAbs generated from one AAV type are unable to neutralize the transduction of other types. We extended this observation by demonstrating that a rationally engineered, muscle-tropic AAV2 mutant containing 5 amino acid substitutions from AAV1 displayed a NAb proﬁle different from those of parental AAV2 and AAV1. Here we found that a single insertion of Thr from AAV1 into AAV2 capsid at residue 265 preserved high muscle transduction, while also changing the immune proﬁle. To better understand the role of Thr insertion at position 265, we replaced all 20 amino acids and evaluated both muscle transduction and the NAb response. Of these variants, 8 mutants induced higher muscle transduction than AAV2. Additionally, three classes of capsid NAb immune proﬁle were deﬁned based on the ability to inhibit transduction from AAV2 or mutants. While no relationship was found between transduction, amino acid properties, and NAb titer or its cross-reactivity, these studies map a critical capsid motif involved in all steps of AAV infectivity. Our results suggest that AAV types can be utilized not only as templates to generate mutants with enhanced transduction efﬁciency but also as sub-strates for repeat administration. Statistical analyses. Student’s two-tailed t test was used to analyze the signiﬁcance of differences between experimental groups and controls.
Characterization of IS Xax1 , a Novel Insertion Sequence Restricted to Xanthomonas axonopodis pv. phaseoli (Variants fuscans and non-fuscans) and Xanthomonas axonopodis pv. vesicatoria (cid:1)

IS Xax1 is a novel insertion sequence belonging to the IS 256 and Mutator families. Dot blot, Southern blot, and PCR analyses revealed that IS Xax1 is restricted to Xanthomonas axonopodis pv. phaseoli (variants fuscans and non-fuscans) and X. axonopodis pv. vesicatoria strains. Directed AFLP also showed that a high degree of polymorphism is associated with IS Xax1 insertion in these strains. Insertion sequences (ISs) are small, mobile, genetic elements that are ubiquitously distributed within bacterial genomes (6, 19). For prokaryotes, IS elements have been classiﬁed into about 20 families based on (i) open reading frame organization, (ii) length and similarity of terminal inverted repeat (IR) sequences, (iii) length of target site duplication (direct target repeat [DR]), and (iv) features of the DDE motif, a conserved amino acid motif called the catalytic triad of bacterial transposases (Tpases) (http://www-is.biotoul.fr/is .html) (19, 29). ISs mediate various DNA rearrangements which can
Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF- (cid:2) B

The type I interferon (IFN) response is part of the ﬁrst-line defense against viral infection. To initiate replication, viruses have developed powerful evasion strategies to counteract host IFN responses. In the present study, we found that the Japanese encephalitis virus (JEV) NS5 protein could inhibit double-stranded RNA (dsRNA)-induced IFN- (cid:2) expression in a dose-dependent manner. Our data further demonstrated that JEV NS5 suppressed the activation of the IFN transcriptional factors IFN regulatory factor 3 (IRF3) and NF- (cid:3) B. However, there was no defect in the phosphorylation of IRF3 and degradation of I (cid:3) B, an upstream inhibitor of NF- (cid:3) B, upon NS5 expression, indicating a direct inhibition of the nuclear localization of IRF3 and NF- (cid:3) B by NS5. Mechanistically, NS5 was shown to interact with the nuclear transport proteins KPNA2, KPNA3, and KPNA4, which competitively blocked the interaction of KPNA3 and KPNA4 with their cargo molecules, IRF3 and p65, a subunit of NF- (cid:3) B, and thus inhibited the nuclear translocation of IRF3 and NF- (cid:3) B. Further-more, overexpression of KPNA3 and KPNA4 restored the activity of IRF3 and NF- (cid:3) B and increased the production of IFN- (cid:2) in NS5-expressing or JEV-infected cells. Addi-tionally, an upregulated replication level of JEV was shown upon KPNA3 or KPNA4 overexpression. These results suggest that JEV NS5 inhibits the induction of type I IFN by targeting KPNA3 and KPNA4. IMPORTANCE JEV is the major cause of viral encephalitis in South and Southeast Asia, with high mortality. However, the molecular mechanisms contributing to the severe pathogenesis are poorly understood. The ability of JEV to counteract the host innate immune response is potentially one of the mechanisms responsible for JEV virulence. Here we demonstrate the ability of JEV NS5 to interfere with the dsRNA-induced nuclear translocation of IRF3 and NF- (cid:3) B by competitively inhibiting the interaction of IRF3 and NF- (cid:3) B with nuclear transport proteins. Via this mechanism, JEV NS5 suppresses the induction of type I IFN and the antiviral response in host cells. These ﬁndings reveal a novel strategy for JEV to escape the host innate immune response and provide new insights into the pathogenesis of JEV. gene (ISGF3) of of and of KPNA3 and suppression of IRF3 and NF- (cid:3) B transcriptional and preventing host antiviral
The impact of inﬂammatory licensing on heme oxygenase-1–mediated induction of regulatory T cells by human mesenchymal stem cells

Mesenchymal stem cells (MSCs) are characterized by their manifold immunomodulatory and regenerative properties. The stress-responsive,cytoprotective,andim-munoregulatory molecule heme oxygen-ase-1 (HO-1) was recently identiﬁed as a key contributor for MSC-mediated suppression of alloactivated T cells. As HO-1 has also been implicated in the induction of regulatory T cells (Tregs), we sought to examine its impact on MSC-driven promotion of Tregs. Human MSCs were shown to induce, in a HO-1–dependent fashion, growth in allo- and T-cell receptor-activated lymphocytes. Because inﬂammatory stimuli modulate (“license”) human MSCs, we were interested in whether an in vitro alloreactive micro-milieu within mixed lymphocyte reactions (MLRs) alters the HO-1 expression. We observed a substantial down-regulation of HO-1 facilitated by yet unidentiﬁed soluble factor(s) produced in an MLR, and most probably occurring at the level of its major transcription-factor NF-E2– factor 2. HO-1 suppressiveness, induction, of IL-10 for MSCs, which were prelicensed in an together, we show that HO-1 produced by human MSCs beyond its direct suppressive function promotes formation of Tr1 and Th3 Tregs and IL-10 production, functions, which are taken over by other molecules, among them COX-2, after an alloreactive priming. ( Blood . 2011;117(18): 4826-4835)
An Analytical Study on Compression Ratio of Video Frames in Stereoscopic Images

: The increasing use of digital video has led to the use of video data compression to allow compact storage and fast video transfer rates. A wide variety of methods are used to compress video streams. Video data contains spatial and temporal redundancy, making uncompressed video streams extremely inefficient. Spatial redundancy is reduced differences between parts of a single frame; this task is known as intraframe compression and is closely related to image compression. Likewise, temporal redundancy can be reduced differences between frames; this task is known as interframe compression, including motion compensation and other techniques. The most common modern standards are MPEG-2, used for DVD and satellite television, and MPEG-4, used for home video. In this paper I analysis the ratio of different video frames in stereoscopic images.
Reinforcement versus Fluidization in Cytoskeletal Mechanoresponsiveness this access benefits you. Your story matters

Every adherent eukaryotic cell exerts appreciable traction forces upon its substrate. Moreover, every resident cell within the heart, great vessels, bladder, gut or lung routinely experiences large periodic stretches. As an acute response to such stretches the cytoskeleton can stiffen, increase traction forces and reinforce, as reported by some, or can soften and fluidize, as reported more recently by our laboratory, but in any given circumstance it remains unknown which response might prevail or why. Using a novel nanotechnology, we show here that in loading conditions expected in most physiological circumstances the localized reinforcement response fails to scale up to the level of homogeneous cell stretch; fluidization trumps reinforcement. Whereas the reinforcement response is known to be mediated by upstream mechanosensing and downstream signaling, results presented here show the fluidization response to be altogether novel: it is a direct physical effect of mechanical force acting upon a structural lattice that is soft and fragile. Cytoskeletal softness and fragility, we argue, is consistent with early evolutionary adaptations of the eukaryotic cell to material properties of a soft inert microenvironment. normalized traction changes were strikingly similar within the three
E cacy of prophylactic methylprednisolone on reducing the risk of post-extubation stridor in an emergency setting: study protocol for a randomized controlled trial

Jingyi Wang Peking Union Medical College Hospital Joseph Harold Walline Chinese University of Hong Kong Lu Yin Peking Union Medical College Hospital Yili Dai Peking Union Medical College Hospital Jiayuan Dai Peking Union Medical College Hospital Huadong Zhu Peking Union Medical College Hospital Xuezhong Yu Peking Union Medical College Hospital Jun Xu (  xujunfree@126.com ) Peking Union Medical College Hospital https://orcid.org/0000-0001-5014-4238
Photovoltaic effects in BiFeO3

We report a photovoltaic effect in ferroelectric BiFeO3 thin films. The all-oxide heterostructures with SrRuO3 bottom and tin doped indium oxide top electrodes are characterized by open-circuit voltages ∼0.8–0.9 V and external quantum efficiencies up to ∼10% when illuminated with the appropriate light. Efficiencies are at least an order of magnitude larger than the maximum efficiency under sunlight (AM 1.5) thus far reported for ferroelectric-based devices. The dependence of the measured open-circuit voltage on film thickness suggests contributions to the large open-circuit voltage from both the ferroelectric polarization and band offsets at the BiFeO3/tin doped indium oxide interface.
Embedded smoke recognition system based on object detection

Fire is one of the most frequent and common disasters endangering public security and threatening social development. There are various causes of fires, but fires that cause major personnel and property losses are usually caused by untimely detection, late alarm, and other reasons. In the initial stage of fire, the traditional smoke-concentrated sensor is often used to detect the temperature of the fire. If immediate and effective measures are not taken in the early stage of fire, it is easy to cause large personnel and property losses. Therefore, aiming at the problem of smoke detection in the early stage of fire, an embedded smoke recognition system based on object detection is proposed in this paper. The system adopts data enhancement to expand the data set, transplants the YOLOv5 object detection algorithm to the embedded system to recognize smoke, and sends the alarm information to the terminal. It has good recognition effect and meets the needs of smoke detection in the early stage of fire.
Dynamic time warping under subsequence

In the mining and analysis of time series data, the similarity measurement process of two time series is essential. The dynamic time warping algorithm DTW (Dynamic Time Warping) is a common algorithm for measuring the similarity of time series. Although DTW has obtained the global optimal solution, it may not be able to achieve local reasonable matching, and the measurement effect is limited. The shape dynamic time warping algorithm shapeDTW (Shape Dynamic Time Warping) enhances the measurement effect by considering point-wise local structure information. In order to continue to improve the measurement effect of the shapeDTW algorithm, this paper analyzes the definition and common methods of the shape descriptor of its algorithm. On the basis of extending the subsequences at each time point, the method of representing subsequences using shape descriptors is directly changed. The DTW value of the subsequence is calculated as the distance value of each time point in the cumulative cost matrix during the alignment of the entire original time series. This method is called subDTW (Subsequence Dynamic Time Warping). The subDTW algorithm enhances the measurement effect of the shapeDTW algorithm to a certain extent. Through the experimental research and analysis of the approximate window size of the segmentation aggregation on the training set, the subDTW algorithm based on the cumulative cost matrix pruning can keep the classification accuracy unchanged. A significant reduction in time overhead is achieved.
Scenario-oriented business architecture modeling method based on ROADS

The ROAD meta-architecture guides the whole enterprise architecture development process with business architecture. In response to the problem that the IDEF0 used in the business activity model has insufficient ability to describe the rich activity trigger sequences and information interaction scenarios between multi-component systems, this paper introduces the scenario model, which is fused with the original IDEF0-based activity model to become a scenario-oriented activity model with hierarchical description capability and scenario timing description capability. The extended ROADS metaarchitecture enables scenario-oriented system modeling and realizes scenario management in business architecture design. Finally, the kindergarten health system is used as an example for validation.
A light-weight convolutional network for liver and tumor segmentation

Automated segmentation of liver and lesion in contrast-enhanced abdominal computed tomography (CT) scans is a crucial step for computer-assisted diagnosis and surgical planning of liver diseases. Although deep convolutional neural networks (DCNNs) have contributed many breakthroughs in liver and lesion segmentation task from CT images, the problem remains challenging due to low segmentation accuracy and high complexity. To address these issues, we proposed a light-weight convolutional neural networks for liver and lesion segmentation from CT images, i.e., LW-Mnet. Firstly, we improve the basic module of MobileNetv3 as the backbone of LW-Mnet. The second is that we employ LWASPP to capture multi-scale feature information for enhance representation power of network. The proposed network is evaluated on the public LiTS dataset, and the results show that LW-Mnet achieved the better performance than other networks with fewer parameters and faster inference speed.
An improved UAV-borne InSAR baseline estimation method based on interferometric phase period

UAV-borne interferometric SAR has unique advantages and has attracted the attention of key research institutions in recent years. Baseline is a crucial parameter in InSAR processing, which is directly related to the accuracy of InSAR measurements. Compared with space-borne InSAR, UAV platform is difficult to keep the flight at the same track, and the flight attitude is unstable, which brings great difficulties to the baseline estimation of UAV-borne InSAR. In this paper, an improved baseline estimation method is proposed. This method derives the relationship between the interference phase period, the slant range, the distance between two ground points, and the phase difference through the interference geometric relationship. The distance between the two points is then substituted into the known parameters for baseline estimation using the least squares method. Compared with the original method, the proposed method can fully exploit the potential of the interferogram data by applying the least square method to solve the formula between flight parameters and baseline parameter to achieve baseline estimation. The simulated results and the flight test results of the original method and the proposed method are Compared. The absolute error, RMSE and standard deviation of both methods are calculated. It shows that the accuracy and robustness of the proposed method are significantly improved.