Miracle-dz/UniFAR-FTUs huggingface dataset:
Enzymatic efficacy of Nimbecidine®, a neem extract, against the phosphatases in certain tissues of the desert locust Schistocerca gregaria (Forskal) (Orthoptera: Acrididae)

The desert locust Schistocerca gregaria is a destructive pest for several crops, particularly which are considered as the main food sources for human and animals. Much attention has been paid to use the plant extracts or plant products for controlling this pest. The present study aimed to investigate the disturbing effect of Nimbecidine on the phosphatase activity in S. gregaria. The penultimate instar nymphs were treated, through the fresh food, with 1.0 and 0.3% Nimbecidine and the activities of acid phosphatase (ACP) and alkaline phosphatase (ALP) were estimated in the last instar nymphs and adults. The most important results could be summarized as follows. Nimbecidine significantly promoted the ACP activity in haemolymph, irrespective of the stage, age, or concentration. In addition, Nimbecidine exhibited a remarkable inducing effect on the enzyme activity in fat bodies, regardless the stage and age, with an exception of the late-aged nymphs in which the enzyme activity was suppressed. Regarding the effect of Nimbecidine on ALP activity in haemolymph of the nymphs and adults, results clearly displayed a general reducing effect of Nimbecidine on the enzyme activity in haemolymph of the last nymphal instar. An exceptional case of promoting action was detected in the newly emerged adults, at the higher concentration. In respect of the effect on ALP activity in fat bodies, results indicated that the enzyme activity was significantly induced in nymphs but reduced in adults.
Coupling breakwalls with oyster restoration structures enhances living shoreline performance along energetic shorelines

Interest and investment in constructing living shorelines rather than harder engineering structures are on the rise worldwide. However, the performance of these interventions in rejuvenating coastal habitats, depositing fine sediments with elevated organic content, and reducing erosion varies widely and is often low along energetic shorelines. In this study, we test the efficacy of a living shoreline design that couples breakwalls and oyster restoration structures, in protecting coastal estuarine ecosystems and their services along energetic shorelines. A field experiment was conducted between 2015 and 2019 along a section of the Atlantic Intracoastal Waterway in northeast Florida, which experiences commercial and recreational vessel traffic. We discovered that organic matter, silt and clay content all increased in sediments collected in the living shorelines compared to paired control treatments. In addition, oysters established and developed into robust reefs on the gabions – wire cages filled with seasoned oyster shells that were used to facilitate oyster recovery within this living shorelines design, although oyster growth was highest where the gabions were placed at lower intertidal elevations. Additionally, salt marsh cordgrass along shoreline margins protected by the living shoreline structures remained stable or began advancing toward the Intracoastal Waterway channel at rates of ~1 m per year, whereas cordgrass in control treatments retreated at rates approaching 2 m per year. This study provides powerful evidence that vessel wake stress is indeed driving ecosystem loss and that simple nature-based living shoreline structures designed to dissipate this energy can slow or reverse ecosystem decline. More research is needed to optimize these nature-based solutions for shoreline protection in coastal and estuarine settings, and to improve
Effect of stocking density on survival rate, growth performance, swim bladder inflation and skeletal deformity of the European sea bass (Dicentrarchus labrax) larvae.

European Sea bass (Dicentrarchus labrax) is considered one of the primarily species to be intensively cultured in the Mediterranean region due to its high commercial value. Recently, the decline in this species market price due to extra-production has forced the aquaculturists for decrement production expenses with enhancing fish quality. ARTICLE INFO ABSTRACT Article History: Received: May 24, 2021 Accepted: June 29, 2021 Online: June 30, 2021 _______________
Women as CEO (Chief Executive Officer) and CFO (Chief Financial Officer): influence of female presence on the quality of accruals

The presence of women in the positions of executive board, senior management and councils has pointed to a significant influence in the reduction of company discretionary accruals. The study started from the assumptions evidenced in hypotheses H1a and H1b that companies with female CEO and/or CFO have less discretionary accruals and so, a higher earnings quality. The empirical model was applied to a sample of 170 non-financial companies listed in B3 S/A – Brasil, Bolsa, Balcão from 2013 to 2018. The results reject H1a. The findings do not reject H1b, that is, there was a significant influence of the female CEO with the decrease in the discretion of accruals, which results in better earnings quality. The survey also recorded the total number of women as CEOs and CFOs, with 25 (2.68%) and 72 (7.73%), respectively, totaling 97 women in both positions.
Antiviral Resistance and Phage Counter Adaptation to Antibiotic-Resistant Extraintestinal Pathogenic <italic toggle='yes'>Escherichia coli</italic>

Extraintestinal pathogenic Escherichia coli (ExPEC), often multidrug resistant (MDR), is a leading cause of urinary tract and systemic infections. The crisis of emergent MDR pathogens has led some to propose bacteriophages as a therapeutic. However, bacterial resistance to phage is a concerning issue that threatens to undermine phage therapy. Here, we demonstrate that E. coli sequence type 131, a circulating pandemic strain of ExPEC, rapidly develops resistance to a well-studied and therapeutically active phage (fHP3). Whole-genome sequencing of the resisters revealed truncations in genes involved in lipopolysaccharide (LPS) biosynthesis, the outer membrane transporter ompA, or both, implicating them as phage receptors. We found ExPEC resistance to phage is associated with a loss of fitness in host microenvironments and attenuation in a murine model of systemic infection. Furthermore, we constructed a novel phage-bacterium bioreactor to generate an evolved phage isolate with restored infectivity to all LPS-truncated ExPEC resisters. This study suggests that although the resistance of pandemic E. coli to phage is frequent, it is associated with attenuation of virulence and susceptibility to new phage variants that arise by directed evolution. IMPORTANCE In response to the rising crisis of antimicrobial resistance, bacteriophage (phage) therapy has gained traction. In the United States, there have been over 10 cases of largely successful compassionate-use phage therapy to date. The resilience of pathogens allowing their broad antibiotic resistance means we must also consider resistance to therapeutic phages. This work fills gaps in knowledge regarding development of phage resisters in a model of infection and finds critical fitness losses in those resisters. We also found that the phage was able to rapidly readapt to these resisters.
PGPM_A_310780 601..607

1Department of Hematology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People’s Republic of China; 2Sydney School of Public Health, The University of Sydney, Camperdown, Sydney, NSW, 2006, Australia; 3Department of Pathology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, People’s Republic of China Background: Glioma is a malignant central nervous system tumor in children, with poor outcomes and prognosis. HMGA2 is a proto-oncogene with increased expression in various malignancies. Methods: We explored the association of HMGA2 polymorphisms with glioma susceptibility in Chinese children using a case-control study (191 cases, 248 controls). HMGA2 single nucleotide polymorphisms (rs6581658 A>G; rs8756 A>C; rs968697 T>C) were genotyped using PCR-based TaqMan. Results: Increased glioma susceptibility was associated with rs6581658 A>G; AG (adjusted odds ratio (OR) = 1.71, 95% confidence interval (CI) = 1.13–2.58, P = 0.010) or GG (adjusted OR = 3.12, 95% CI = 1.26–7.74, P = 0.014) genotype carriers had significantly raised glioma risk compared with AA genotype carriers. The rs6581658 AG/GG (adjusted OR = 1.85, 95% CI = 1.25–2.73, P = 0.002) and AA/GG (adjusted OR = 2.58, 95% CI = 1.05–6.33, P = 0.038) genotypes were associated with an increased risk of glioma relative to the AA genotype. Subjects with 2–3 risk genotypes had a significantly elevated risk (adjusted OR = 1.93, 95% CI = 1.31–2.84, P = 0.001) relative to those with 0–1 risk genotype. Conclusion: HMGA2 rs6581658 A>G is associated with glioma susceptibility in Chinese children.
Suicidal Behaviors Among Youths in Mississippi, United States

Suicidal behaviors play a major role in suicidal deaths among adolescents in the United States. This study examines the prevalence of suicidal behaviors among youths in Mississippi by age, race/ethnicity, grade, and gender. Data were analyzed from the Mississippi Youth Risk Behavior Survey for 2019. The survey employed a representative sample of students in grades 9 – 12. The prevalence of suicidal behaviors among participants was adjusted for gender, age, race, and grade reference data from the CDC growth chart. Differences in the groups were examined with univariate t-test statistical analysis at pvalue<0.05 and frequency distribution to determine the percentage differences. Female youths had higher prevalence rates of seriously considering suicide (23.2%) and making a plan to attempt suicide (14.1%) when compared to the male participants with prevalence rates of 14.1% and 12.1% respectively. Black female youths (16.2%) had higher rates of attempting suicide than the black male youths (13.0%). However, male youths (4.0%) had a higher rate of “suicide attempt with an injury that requires medical treatment" when compared to females (3.4%); with the black male youths (13.0%) having higher rates than the white male youths (7.8%). Participants in 12th grade had higher rates of suicide attempts when compared to other grades. There is a concerning increased risk of suicidal behaviors especially among male youths and black youths in Mississippi. Prevention and intervention programs should target these groups in other to reduce these suicidal behavioral risks.
Development of a Virtual Learning Environment based on Gamefication to Improve Mathematical Concepts and Skills for Deaf Students

In education in recent times, especially during the outbreak of Covid 19, the interest of education professionals has become to search for the most appropriate ways to use technology as a motivational tool in education. The use of gamification in education is very important because it works to arouse students' interest and reduce learning time. The current study aims to determine the effects of applying a virtual learning environment based on gamification on improving the achievement and practical skills of deaf students in mathematics at the primary stage in Egypt. Java, JavaScript, , PHP, CSS, HTML, MSQL, and AppServ, are used to develop the application. The study followed the quasi-experimental research method. The application was applied to students from Al-Amal School for the deaf and hard of hearing in Damietta - Egypt. The study used two tools: an achievement test, and a test of practical skills in mathematics after rationing. The value of the reliability test was more than 0.89. The t-test was used to analyze the students' scores in the pre-and post-test, and the two null hypotheses were tested at the significance level of 0.05. The results showed the effectiveness of the virtual learning environment based on gamification in developing the achievement and practical skills of deaf students in mathematics.
Methylcellulose-Cellulose Nanocrystal Composites for Optomechanically Tunable Hydrogels and Fibers

Chemical modification of cellulose offers routes for structurally and functionally diverse biopolymer derivatives for numerous industrial applications. Among cellulose derivatives, cellulose ethers have found extensive use, such as emulsifiers, in food industries and biotechnology. Methylcellulose, one of the simplest cellulose derivatives, has been utilized for biomedical, construction materials and cell culture applications. Its improved water solubility, thermoresponsive gelation, and the ability to act as a matrix for various dopants also offer routes for cellulose-based functional materials. There has been a renewed interest in understanding the structural, mechanical, and optical properties of methylcellulose and its composites. This review focuses on the recent development in optically and mechanically tunable hydrogels derived from methylcellulose and methylcellulose-cellulose nanocrystal composites. We further discuss the application of the gels for preparing highly ductile and strong fibers. Finally, the emerging application of methylcellulose-based fibers as optical fibers and their application potentials are discussed.
Hole diffusion across leaky amorphous TiO2 coating layers for catalytic water splitting at photoanodes

We investigate the mechanism of hole diffusion across leaky amorphous TiO2 (am-TiO2) layers. Through ab initio molecular dynamics simulations, we construct an atomistic model of am-TiO2 consistent with the experimental characterization. We first demonstrate that the oxygen vacancies do not occur in am-TiO2, as they can be assimilated by the amorphous structure upon structural rearrangement. Hence, their role in hole diffusion is ruled out. In contrast, O–O peroxy linkages are formed in pristine am-TiO2 upon injection of excess holes, with an associated defect level lying at 1.25 ± 0.15 eV above the valence band of the material. We show that such linkages can provide a viable mechanism for hole diffusion in am-TiO2, as illustrated by a diffusion path of 1.2 nm with energy barriers lower than 0.5 eV in our atomistic model of am-TiO2.
Hepatotoxicity Risk Profile of Indonesian Due to Polymorphism of NAT2 and CYP2E1 in Isoniazid Metabolism

This article presents data on drug-induced liver injury events' risk profile due to NAT2 and CYP2E1 polymorphisms in isoniazid metabolism in Indonesian populations among various populations of several countries. The research took place through a review of the literature obtained from google scholar. The library search uses three variants of the keyword: (1) "pharmacogenomic and tuberculosis and INH and NAT2 and CYP2E1 and polymorphism", (2) "isoniazid and hepatotoxicity and polymorphism and N-acetyltransferase," (3) "isoniazid and hepatotoxicity and polymorphism and CYP2E1". Analysis of hepatotoxic risk based on the odds ratio (confidence interval) using Stata MP 14th edition software. The study of drug-induced liver injury events' risk based on various NAT2 acetylation rates involved 2,140 populations from 8 countries, while the risk analysis based on CYP2E1 allele variety involved 1,530 populations from 5 countries. The literature review shows that the Indonesian population's isoniazid-induced liver injury events' risk with slow acetylator NAT2 enzymes and people with CYP2E1*c1/c2 is three times higher than other populations in various countries. Further, people who have the combination slow acetylator NAT2 and CYP2E1*c1/c2 have more druginduced liver injury events' risk.
The Differences of Left Lateral and Head Elevation Position toward Heart Rate of Newborns with Asphyxia in the Perinatology Room RSUD Dr. Soediran Mangun Sumarso Wonogiri

BACKGROUND: Asphyxia delivery results in hypoxic-ischemic encephalopathy and multiorgan failure. The organ most affected by hypoxia is the cardiovascular system. Newborns with asphyxia have a lack of oxygen (hypoxia) and have an increased heart rate (tachycardia). Giving baby positions, such as supination position, pronation, right lateral, left lateral, and head elevation, are expected to improve the hemodynamic of newborns with asphyxia. AIM: This study was to determine the difference in effect between left lateral position and the head elevation position on the heart rate of newborns with asphyxia in the perinatology room of RSUD Dr. Soediran Mangun Sumarso Wonogiri. METHODS: This research is a quasi-experimental quantitative study with a preand post-test non-equivalent control group design. Sampling using non-probability sampling technique with consecutive sampling. The sample was divided into two groups, namely, the intervention group with 30 respondents who got the left lateral position and the control group with 30 respondents who got the head elevation position. Data analysis was performed using the Statistical Package for the Social Sciences parametric test with paired t-test and independent t-test. RESULTS: The results of paired t-test analysis in the intervention group obtained p = 0.003 (p < 0.05) and in the control group obtained p < 0.001 (p < 0.05), which means that both have a significantly on changes in the heart rate of newborns with asphyxia. The results of the independent t-test analysis obtained p = 0.191 (p < 0.05), which means that there is no significant difference in the heart rate of newborns with asphyxia in the intervention and control groups. CONCLUSION: Both interventions, giving the left lateral position and the head elevation position, have a significantly effect on changes in the heart rate of newborns with asphyxia. Edited by: Ksenija Bogoeva-Kostovska Citation: Rizqiea NS, Aini SN, Utami RDP, Ratnawati R, Wardani K. The Differences of Left Lateral and Head Elevation Position toward Heart Rate of Newborns with Asphyxia in the Perinatology Room RSUD Dr. Soediran Mangun Sumarso Wonogiri. Open Access Maced J Med Sci. 2021 May 24; 9(B):492-496. https://doi.org/10.3889/oamjms.2021. 6192
Effect of Graphene Oxide (GO) on the Surface Morphology & Hydrophilicity of Polyethersulfone (PES)

Membrane has been widely used in water and wastewater treatment. One of the major issues related membrane separation is concentration polarization or fouling, which can lead to a decline of flux and premature failure of membrane. However, fouling can be controlled by modification of membrane properties such as morphology and hydrophilicity. In this work, a modification of polymeric membrane, polyethersulfone (PES) was carried out using graphene oxide in order to attain high antifouling characteristics. Graphene oxide (GO) was added at different compositions ranging from (0.1 wt%-1.0 wt%). GO was synthesized using modified Hummers’ method and characterized using XRD and FTIR prior to using it as additive for the PES membrane. The prepared PES-GO composite membranes were characterized using FTIR and SEM, Contact angle measurement and pure water flux test were then conducted to investigate the hydrophilicity of the PES-GO membranes. It was found that the additions of GO has significantly improved the hydrophilicity of the membranes.
A entropia de Shannon: uma abordagem axiomática Shannon’s entropy: an axiomatic approach

Palavras-chave Axiomas Entropia Comunicação Teoria de Shannon Equação Funcional Resumo A palavra “entropia” surgiu no ano de 1864, nos trabalhos de Termodinâmica de Rudolf Clausius. Em 1948, Claude E. Shannon utiliza esse mesmo nome para designar uma medida de informação em seu modelo matemático de comunicação, fundamentado nos conceitos de emissor, receptor, canal, ruı́do, redundância, codificação e decodificação. Com a me-
RELATIONSHIP BETWEEN RED BLOOD CELL AND PLATELET INDICES IN IRON DEFICIENCY ANEMIA

Objective: To find out the correlation between the red blood cell and platelet indices in patients presenting with iron deficiency anemia at a tertiary care hospital of Pakistan. Study Design: Cross-sectional study. Place and Duration of Study: Department of Hematology, Combined Military Hospital Lahore, from Sep 2018 to Mar 2019. Methodology: The patients of age 1-70 years of either gender presenting with IDA were included in the study. The blood sample of patients were sent to laboratory to assess the red blood cell and platelet indices. SPSS-23 was used to analyze data. Results: Two hundred and seven patients fulfilling the inclusion criteria were included in this study. The mean age was 25.6 ± 17.8years. Correlation was weak and insignificant between haemoglobin and packed cell volume (r=-0.385**, p<0.01), haemoglobin and mean cell volume (r=-0.225**, p<0.01), packed cell volume and mean cell haemoglobin (r =0.263**, p<0.01), & mean cell haemoglobin and mean platelet volume (r=0.143*, p<0.05). Correlation was moderate and significant between platelet distribution width and mean platelet volume (r=0.511**) & platelet distribution width and platelet large cell ratio (0.502**, p<0.01). Correlation was strong between mean platelet volume and platelet large cell ratio (r=0.759**, p<0.01). Conclusion: In conclusion, there was significant relation between red blood cell and platelets indices in iron deficiency anemia. Furthermore, haemoglobin and packed cell volume are weekly correlated, platelet distribution width and mean platelet volume are moderately correlated and mean platelet volume and platelet large cell ratio are strongly correlated.
red Application of Tensor Decomposition to Gene Expression of Infection of Mouse Hepatitis Virus can Identify Critical Human Genes and Efffective Drugs for SARS-CoV-2 Infection

To better understand the genes with altered expression caused by infection with the novel coronavirus strain SARS-CoV-2 causing COVID-19 infectious disease, a tensor decomposition (TD)-based unsupervised feature extraction (FE) approach was applied to a gene expression profile dataset of the mouse liver and spleen with experimental infection of mouse hepatitis virus, which is regarded as a suitable model of human coronavirus infection. TD-based unsupervised FE selected 134 altered genes, which were enriched in protein-protein interactions with orf1ab, polyprotein, and 3C-like protease that are well known to play critical roles in coronavirus infection, suggesting that these 134 genes can represent the coronavirus infectious process. We then selected compounds targeting the expression of the 134 selected genes based on a public domain database. The identified drug compounds were mainly related to known antiviral drugs, several of which were also included in those previously screened with an in silico method to identify candidate drugs for treating COVID-19.
The Significance of EFL Learners’ Criteria Awareness of Task-Based Language Teaching

The purpose of this study is to explore whether L2 learners improve their L2 speech presentations for English communication in TBLT, and whether their awareness of criteria influences their learning. It also seeks to determine the relationship between learners’ awareness and leaners’ performance test results. A questionnaire for learners’ awareness was developed to measure to what extent learners are aware of the criteria of Task-based Language Assessment (TBLA). The criteria provide an indication of what L2 learners need to develop: introduction, body, conclusion, performance, contents quality, language quality, practice, fluency, and grammar. Data were collected from 67 learners who enrolled in a speech presentation class and participated in the present study. The results showed statistically significant improvement in performance test of TBLT in the Experimental Group (EG) with higher criteria awareness. In addition, the correlation coefficient was significant between performance test results and higher results in the criteria awareness questionnaire. The overall results indicated that L2 learner’s intentional focus on criteria in TBLT had a strong influence initiating a type of criteria awareness and stimulating related types of awareness, ushering L2 learners toward more autonomous learning. However, further refinement of the criteria should be considered depending on the EFL context.