Miracle-dz/UniFAR-FTUs huggingface dataset:
ILC2s Control Microfilaremia During Litomosoides sigmodontis Infection in Rag2-/- Mice

Group 2 innate lymphoid cells (ILC2s) are inducers of type 2 immune responses, but their role during filarial infection remains unclear. In the present study, we used the Litomosoides sigmodontis rodent model of filariasis to analyze ILC2s during infection in susceptible BALB/c mice that develop a chronic infection with microfilaremia and semi-susceptible C57BL/6 mice that eliminate the filariae shortly after the molt into adult worms and thus do not develop microfilaremia. ILC2s (CD45+ Lineage- TCRβ- CD90.2+ Sca-1+ IL-33R+ GATA-3+) were analyzed in the pleural cavity, the site of L. sigmodontis infection, after the infective L3 larvae reached the pleural cavity (9 days post infection, dpi), after the molt into adult worms (30dpi) and during the peak of microfilaremia (70dpi). C57BL/6 mice had significantly increased ILC2 numbers compared to BALB/c mice at 30dpi, accompanied by substantially higher IL-5 and IL-13 levels, indicating a stronger type 2 immune response in C57BL/6 mice upon L. sigmodontis infection. At this time point the ILC2 numbers positively correlated with the worm burden in both mouse strains. ILC2s and GATA-3+ CD4+ T cells were the dominant source of IL-5 in L. sigmodontis-infected C57BL/6 mice with ILC2s showing a significantly higher IL-5 expression than CD4+ T cells. To investigate the importance of ILC2s during L. sigmodontis infection, ILC2s were depleted with anti-CD90.2 antibodies in T and B cell-deficient Rag2-/- C57BL/6 mice on 26-28dpi and the outcome of infection was compared to isotype controls. Rag2-/- mice were per se susceptible to L. sigmodontis infection with significantly higher worm burden than C57BL/6 mice and developed microfilaremia. Depletion of ILC2s did not result in an increased worm burden in Rag2-/- mice, but led to significantly higher microfilariae numbers compared to isotype controls. In conclusion, our data demonstrate that ILC2s are essentially involved in the control of microfilaremia in Rag2-/- C57BL/6 mice.
Comparative Analysis of the Status and Influencing Factors of Immunization Among Children Between Registered and Floating Population

Background A vaccine is an effective tool to reduce the gap between the rich and the poor and improve health equity, through which a number of serious childhood diseases can be successfully prevented or eradicated. This study is aimed to compare the current situation of vaccination and related factors among children in China's registered residents and floating population, to provide a reference for achieving the 100% vaccination rate in China. Methods The data used for this study are from the 2017 National Migrants Dynamic Monitoring Special Survey data. A self-designed questionnaire was used to collect information, such as socio-demographics, vaccination status of children, and so on, on the registered population and floating population. Descriptive statistics and a chi-square independence test were used to describe the information and to compare the vaccination status of children under different sociodemographic characteristics. Binary logistic regression was employed to analyze influencing factors associated with vaccination of children. Results The findings showed that 94.39% of children in registered residence were completely vaccinated, which was significantly higher than that of the floating children (91.68%, p < 0.001). The region, parents' education level, and marital status were found to be significant risk factors for complete vaccination of children regardless of the registered or floating population. In addition, ethnicity and length of time to the nearest medical institution were unique risk factors for complete vaccination of children in registered residence. And, health record was an independent influencing factor for vaccination of children of floating population. Conclusion Compared with registered population, floating population was at a disadvantage in using basic public health services, especially in children's vaccination. To achieve 100% vaccination for children, particular interventions should be taken for different populations.
Tracking Memes in the Wild: Visual Rhetoric and Image Circulation in Environmental Communication

Drawing on recent scholarship in environmental communication and rhetoric, this essay examines the role of visual circulation in digital environmental discourse. We argue that while environmental image circulation is often viewed as an ambivalent, or even performative, practice for environmental citizenship, it is also an important space for cultivating participatory culture online. Adapting a version of Laurie Gries' “Iconographic Tracking” method, we offer three case studies that demonstrate how the digital circulation of environmental memes and iconic images offers important tactics for engaging digital publics that can be deployed by public communication practitioners. Subsequently, we argue for a more nuanced view of image circulation as both a performative and a participatory strategy for environmental communication.
A Large Silicon Pool in Small Picophytoplankton

Marine picophytoplankton (<2 μm) play a key role in supporting food web and energy flow in the ocean, and are major contributors to the global marine carbon (C) cycle. In recent years, picophytoplankton have been found to have significant silica (Si) accumulation, a finding which provides a new sight into the interaction of marine C and Si cycles and questions the overwhelming role of large diatoms (>2 μm) in the Si cycle. As picophytoplankton have high cell abundance and wide distribution in the open ocean, exploring their influences on the C and Si cycles as well as other element cycles are becoming new scientific hotspots. However, there are still few studies on the physiology and ecology of picophytoplankton, especially their potential roles in the biogeochemical Si cycle at present. Thus, it is necessary to accurately evaluate and quantify the contributions of picophytoplankton to the C and Si cycles, and to further understand their C and Si sinking mechanisms. In this review, we expect to have a novel understanding of picophytoplankton Si pool and regulation mechanism by conducting targeted studies on these scientific issues. This also provides a premise foundation and theoretical framework for further study of the role of small cells in the global ocean Si cycle and the coupling of C and Si cycles.
Behaviour Impact Analysis of Tuna Purse Seiners in the Western and Central Pacific Based on the BRT and GAM Models

Understanding the spatial pattern of human fishing activity is very important for fisheries resource monitoring and spatial management. To understand the spatial distribution of tuna purse seiner operations in the western and central Pacific Ocean and its relationship with the marine environment, this paper uses the AIS data of the western and central Pacific Tuna purse seiners from 2015 to 2020 to excavate spatial fishing effort information, which is combined with 24 marine environmental factors in the same period, including sea surface and subsurface levels using the boosted regression trees (BRT) model and general additive model (GAM) to construct the nonlinear relationship between the spatial distribution of fishing effort and marine ecological environmental factors and to discuss and analyse the niche of tuna purse seiners in the high seas. The results show that the average score of cv-AUC (cross-validated area under the curve) obtained by the BRT model training reaches 0.93, the average accuracy rate is 0.84, and the explained deviance is 43%; the average score of AUC (area under the curve) obtained by the GAM model training reaches 0.81, the average accuracy rate is 0.77, and the explained deviance is 34%. The results of BRT prior to GAM model. Using the BRT model for prediction, the results show that the average cv-AUC score for forecasting fishing effort in 2020 reaches 0.83, and the average accuracy rate of overall classification reaches 0.77. The results of factor analysis show that the water temperature at 100 m depth and longitude are the most important factors affecting the fishing effort of tuna purse seiners, and their contribution rates to the fishing effort of vessels are 12.38% and 9.76%, respectively, followed by sea surface temperature, latitude and DSH. The contribution to the fishing effort of tuna purse seiners was also large, accounting for 9.57%, 8.75%, and 7.11%, respectively; the 100-meter-deep chlorophyll and temperature gradient value contributed the least, 1.44% and 1.16%, respectively; tuna purse seiners are more likely to operate in the 100-metre water temperature of 25-29°C and sea surface temperature of 29-31°C. In terms of space, tuna purse seiners are more likely to operate in the 5°S-5°N latitudinal region and near the western sea area of 180°E. It is predicted that the modelled fishing effort of fishing vessels in 2020 and the actual fishing effort of fishing vessels have a relatively good spatial distribution. Research helps to understand the environmental impact of changes in the spatial distribution of tuna purse seiners and provides support for the management of tuna purse seine vessels in the western and central Pacific.
Editorial: Climate Services for Adaptation to Sea-Level Rise

1 Risk and Prevention Department, Bureau de Recherches Géologiques et Minières (BRGM), Orléans, France, 2 Tyndall Centre of Climate Change Research, University of East Anglia, Norwich, United Kingdom, 3 Institute for Marine and Atmospheric Research Utrecht, Utrecht University, Utrecht, Netherlands, 4 World Climate Research Programme (WCRP) Secretariat, World Meteorological Organisation, Geneva, Switzerland, 5 International Climate and Ocean: Variability, Predictability and Change (CLIVAR) Project Office, Qingdao, China
Architectural Features and Resistance to Food-Grade Disinfectants in Listeria monocytogenes-Pseudomonas spp. Dual-Species Biofilms

Listeria monocytogenes is considered a foodborne pathogen of serious concern capable of forming multispecies biofilms with other bacterial species, such as Pseudomonas spp. , adhered onto stainless steel (SS) surfaces. In an attempt to link the biofilms’ morphology and resistance to biocides, dual-species biofilms of L. monocytogenes, in co-culture with either Pseudomonas aeruginosa, Pseudomonas fluorescens, or Pseudomonas putida, were assayed to ascertain their morphological characteristics and resistance toward benzalkonium chloride (BAC) and neutral electrolyzed water (NEW). Epifluorescence microscopy analysis revealed that each dual-species biofilm was distributed differently over the SS surface and that these differences were attributable to the presence of Pseudomonas spp. Confocal laser scanning microscopy (CLSM) assays demonstrated that despite these differences in distribution, all biofilms had similar maximum thicknesses. Along with this, colocalization analyses showed a strong trend of L. monocytogenes to share location within the biofilm with all Pseudomonas assayed whilst the latter distributed throughout the surface independently of the presence of L. monocytogenes, a fact that was especially evident in those biofilms in which cell clusters were present. Finally, a modified Gompertz equation was used to fit biofilms’ BAC and NEW dose-response data. Outcomes demonstrated that L. monocytogenes was less susceptible to BAC when co-cultured with P. aeruginosa or P. fluorescens, whereas susceptibility to NEW was reduced in all three dual-species biofilms, which can be attributable to both the mechanism of action of the biocide and the architectural features of each biofilm. Therefore, the results herein provided can be used to optimize already existing and develop novel target-specific sanitation treatments based on the mechanism of action of the biocide and the biofilms’ species composition and structure.
The Urobiomes of Adult Women With Various Lower Urinary Tract Symptoms Status Differ: A Re-Analysis

The discovery of the urinary microbiome (urobiome) has created opportunities for urinary health researchers who study a wide variety of human health conditions. This manuscript describes an analysis of catheterized urine samples obtained from 1,004 urobiome study participants with the goal of identifying the most abundant and/or prevalent (common) taxa in five clinically relevant cohorts: unaffected adult women (n=346, 34.6%), urgency urinary incontinence (UUI) (n=255, 25.5%), stress urinary incontinence (SUI) (n=50, 5.0%), urinary tract infection (UTI) (n=304, 30.4%), and interstitial cystitis/painful bladder syndrome (IC/PBS) (n=49, 4.9%). Urine was collected via transurethral catheter and assessed for microbes with the Expanded Quantitative Urine Culture (EQUC) technique. For this combined analytic cohort, the mean age was 59 ± 16; most were Caucasian (n=704, 70.2%), Black (n=137, 13.7%), or Hispanic (n=130, 13.0%), and the mean BMI was 30.4 ± 7.7. Whereas many control or IC/PBS cohort members were EQUC-negative (42.4% and 39.8%, respectively), members of the other 3 cohorts were extremely likely to have detectable microbes. The detected urobiomes of the controls and IC/PBS did not differ by alpha diversity or genus level composition and differed by only a few species. The other 3 cohorts differed significantly from the controls. As expected, Escherichia was both prevalent and highly abundant in the UTI cohort, but other taxa also were prevalent at more moderate abundances, including members of the genera Lactobacillus, Streptococcus, Staphylococcus, Corynebacterium, Actinomyces, and Aerococcus. Members of these genera were also prevalent and highly abundant in members of the UUI cohort, especially Streptococcus anginosus. Intriguingly, these taxa were also detected in controls but at vastly lower levels of both prevalence and abundance, suggesting the possibility that UUI-associated symptoms could be the result of an overabundance of typical urobiome constituents. Finally, prevalence and abundance of microbes in the SUI cohort were intermediate to those of the UUI and control cohorts. These observations can inform the next decade of urobiome research, with the goal of clarifying the mechanisms of urobiome community composition and function. There is tremendous potential to improve diagnosis, evaluation and treatment for individuals affected with a wide variety of urinary tract disorders.
Distributed Economic Dispatch Based on Finite-Time Double-Consensus Algorithm of Integrated Energy System

To reduce the operating cost and enhance the energy utilization efficiency of the integrated energy system (IES), an economic dispatch algorithm is proposed based on finite-time double-consensus. First, an economic dispatch model of IES under two modes of operation, islanded and grid-connected, is constructed considering energy transmission losses. After that, the optimal improved incremental cost and power output allocation of the IES can be found out in finite time. The proposed algorithm contains two finite-time consistency protocols simultaneously that can solve the optimal values of the incremental cost of electricity and heat of integrated energy system, solving the strong coupling problem of multi-energy systems. The proposed algorithm not only has a faster convergence rate but also enables switching freely between the two operation modes. In addition, a distributed method for quickly discovering the total system power mismatch is proposed in the process of algorithm solving. The finite-time convergence of the proposed algorithm is demonstrated. Finally, the IES simulation based on the IEEE 30-node power system and the Bali 32-node thermal system is established. The analysis of the simulation results shows that the algorithm proposed in this paper is effective.
Prevention and Treatment of Glucocorticoid-Induced Osteoporosis in Adults: Consensus Recommendations From the Belgian Bone Club

Glucocorticoids are effective immunomodulatory drugs used for many inflammatory disorders as well as in transplant recipients. However, both iatrogenic and endogenous glucocorticoid excess are also associated with several side effects including an increased risk of osteoporosis and fractures. Glucocorticoid-induced osteoporosis (GIOP) is a common secondary cause of osteoporosis in adults. Despite availability of clear evidence and international guidelines for the prevention of GIOP, a large treatment gap remains. In this narrative review, the Belgian Bone Club (BBC) updates its 2006 consensus recommendations for the prevention and treatment of GIOP in adults. The pathophysiology of GIOP is multifactorial. The BBC strongly advises non-pharmacological measures including physical exercise, smoking cessation and avoidance of alcohol abuse in all adults at risk for osteoporosis. Glucocorticoids are associated with impaired intestinal calcium absorption; the BBC therefore strongly recommend sufficient calcium intake and avoidance of vitamin D deficiency. We recommend assessment of fracture risk, taking age, sex, menopausal status, prior fractures, glucocorticoid dose, other clinical risk factors and bone mineral density into account. Placebo-controlled randomized controlled trials have demonstrated the efficacy of alendronate, risedronate, zoledronate, denosumab and teriparatide in GIOP. We suggest monitoring by dual-energy X-ray absorptiometry (DXA) and vertebral fracture identification one year after glucocorticoid initiation. The trabecular bone score might be considered during DXA monitoring. Extended femur scans might be considered at the time of DXA imaging in glucocorticoid users on long-term (≥ 3 years) antiresorptive therapy. Bone turnover markers may be considered for monitoring treatment with anti-resorptive or osteoanabolic drugs in GIOP. Although the pathophysiology of solid organ and hematopoietic stem cell transplantation-induced osteoporosis extends beyond GIOP alone, the BBC recommends similar evaluation, prevention, treatment and follow-up principles in these patients. Efforts to close the treatment gap in GIOP and implement available effective fracture prevention strategies into clinical practice in primary, secondary and tertiary care are urgently needed.
Use of an Edaphic Microarthropod Index for Monitoring Wildfire Impact on Soil in Mediterranean Pine Forests

The aim of this study was to investigate the potential of the Biological Soil Quality index (QBS-ar index) for monitoring the impact of wildfires on Mediterranean pine forests soils. The QBS-ar is a simplified eco-morphological index, based on edaphic microarthropods. We analyzed the QBS-ar values of pine stands burned one or two times and at different time spans from fire (from 10 days to 11 years after fire), in comparison to the unburned control area. Effect of fire on the biological soil quality evaluated with QBS-ar index was analyzed using univariate and multivariate techniques. Our results showed a significant variation of QBS-ar values between burned areas and those never burned. The impact of fire on the QBS-ar index and the microarthropod community was higher in the areas burned twice. A relevant average dissimilarity of taxonomic groups was found between the control area and the area burned twice, but also between the control area and the one observed 3 months after the fire. The taxa that contributed more to the dissimilarity were Pseudoscorpiones and Diplopoda, which reduced their presence after fire. Our study shows that the QBS-ar index is a dependable method for monitoring the impact of fire on soil quality in forest ecosystems and indicates that edaphic microarthropods communities in these Mediterranean pine forests return to the before fire condition 11 years after fire. The QBS-ar index could therefore be a useful tool for monitoring forest ecosystem rehabilitation after fire.
Insights Into Platelet-Derived MicroRNAs in Cardiovascular and Oncologic Diseases: Potential Predictor and Therapeutic Target

Non-communicable diseases (NCDs), represented by cardiovascular diseases and cancer, have been the leading cause of death globally. Improvements in mortality from cardiovascular (CV) diseases (decrease of 14%/100,000, United States) or cancers (increase 7.5%/100,000, United States) seem unsatisfactory during the past two decades, and so the search for innovative and accurate biomarkers of early diagnosis and prevention, and novel treatment strategies is a valuable clinical and economic endeavor. Both tumors and cardiovascular system are rich in angiological systems that maintain material exchange, signal transduction and distant regulation. This pattern determines that they are strongly influenced by circulating substances, such as glycolipid metabolism, inflammatory homeostasis and cyclic non-coding RNA and so forth. Platelets, a group of small anucleated cells, inherit many mature proteins, mRNAs, and non-coding RNAs from their parent megakaryocytes during gradual formation and manifest important roles in inflammation, angiogenesis, atherosclerosis, stroke, myocardial infarction, diabetes, cancer, and many other diseases apart from its classical function in hemostasis. MicroRNAs (miRNAs) are a class of non-coding RNAs containing ∼22 nucleotides that participate in many key cellular processes by pairing with mRNAs at partially complementary binding sites for post-transcriptional regulation of gene expression. Platelets contain fully functional miRNA processors in their microvesicles and are able to transport their miRNAs to neighboring cells and regulate their gene expression. Therefore, the importance of platelet-derived miRNAs for the human health is of increasing interest. Here, we will elaborate systematically the roles of platelet-derived miRNAs in cardiovascular disease and cancer in the hope of providing clinicians with new ideas for early diagnosis and therapeutic strategies.