Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of class participation in non-face-to-face CPR training for medical students

Background Cardiopulmonary resuscitation (CPR) education requires that learners practice key skills to promote mastery. Our aim in this study was to evaluate differences in post-education performance and class participation during CPR training between face-to- face (FF) and non-face-to-face (NFF) learning formats. Methods This was a randomized controlled study of third-year medical students from two university hospital, allocated to either the FF or NFF format for CPR education. The learning scenario addressed single-person CPR, consisting of chest compression only, and excluded breathing. The Kahoot! application was used for NFF. Between-group comparisons for class participation and CPR skills were based on video recordings. Results Seventy students participated in our study, with 35 randomly allocated to the FF and NFF groups. There were no between-group differences in terms of age, sex, previous basic life support training, and willingness and confidence in performing CPR. Compared to the FF group, the NFF group demonstrated significant differences during CPR, including fewer calling for assistance and using of defibrillator (p = 0.006), as well as fewer checking for breathing (p = 0.007), and fewer counting during chest compression (p = 0.006). Additionally, < 30% of learners in the NFF group completed rhythm analysis after the last defibrillator shock delivery and resumed immediate chest compression (p < 0.001). All students in both groups passed the post-training assessment. Conclusion Class participation in NFF learning was lower than that in FF learning. Although the post-education evaluation in the NFF group was not inferior, efforts on promoting active participation in NFF learning are required.
Electrically switchable spatial filter based on polymer-dispersed liquid crystal film

This work demonstrates the feasibility of using polymer-dispersed liquid crystal (PDLC) films as electrically switchable spatial filters in the optical signal process. The fabrication relies on the fact that the size of the LC droplet formed in a PDLC film is inversely proportional to the intensity of curing. Controlling the driving voltage on the PDLC sample can filter particular spatial frequencies in the Fourier optical signal process. A simulation is also performed, and the results are highly consistent with those of experiments.
A generalization of the Hall semigroup of a band

Abstract Let E be a band and ε a compatible partition on it. If S is an orthodox semigroup with band of idempotents E such that there exists a congruence on S inducing the partition ε then we define a homomorphism of S into a Hall semigroup whose kernel is the greatest congruence on S inducing the partition ε. On the other hand, we define a subsemigroup of the Hall semigroup WE possessing the property that S is an othodox semigroup with band of idempotents E which has a congruence inducing ε if and only if the range of the Hall homomoprhism of S into WE is contained in .
Jumping is not just about height: Biosocial becomings as an integrative approach in understanding contextualized jump performance in Maasai society

Studies focused on jumping performance in humans have so far investigated either its biological or sociocultural significance, with very little attentions paid to the inseparable relations of these two aspects in daily life of people. Integrating both ethnographic and biomechanical methods, this research investigated the biosocial features of the jump performance of Maasai youth in its most well observed context, the wedding ceremony. Ethnographic data were used to explain the social status of participants, the physical movements and singing tempo of performers, and their interactions. Biomechanical methods were applied to assess the heights and frequencies of identified repetitive double-legged vertical jumps (n = 160, from 15 male youths). All youth performers followed a certain posture pattern, paying specific attention to their final landing. Large variations exist in their jumping heights [coefficient of variation (CV) = 0.237]; however, the frequency in jump repetitions were maintained with the least variations (CV = 0.084). Cheering interactions were confirmed, but with no significant difference in height between the cheered and non-cheered groups. These results indicate that the Maasai youths did not compete for jump height during local ceremonies. Rather, they emphasized the rhythmical retention of jumps, corresponding to other youth mates who were singing alongside. In the broader context of human behaviors, the analysis addresses the diverse meanings of motor performances in different daily contexts that reject the generalized sports regime of “higher/faster-the-better”.
Antimicrobial resistance patterns of bacterial pathogens recovered from the urine of patients at Canadian hospitals from 2009 to 2020

Abstract Objectives To investigate in vitro susceptibility patterns of bacterial pathogens recovered from the urine of outpatients (isolates from outpatient clinics or emergency departments) and hospital inpatients across Canada from 2009 to 2020 as part of the CANWARD study Methods Canadian hospital microbiology laboratories submitted bacterial pathogens cultured from urine to the CANWARD study coordinating laboratory on an annual basis (January 2009 to December 2020). Antimicrobial susceptibility testing was performed by CLSI broth microdilution, with MICs interpreted by current CLSI breakpoints. Results In total, 4644 urinary pathogens were included in this study. Escherichia coli was recovered most frequently (53.3% of all isolates), followed by Enterococcus faecalis, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa and Staphylococcus aureus. Together, these six species accounted for 84.2% of study isolates. Nitrofurantoin demonstrated excellent in vitro activity versus E. coli, with 97.6% of outpatient and 96.1% of inpatient isolates remaining susceptible. In contrast, E. coli susceptibility rates were lower for ciprofloxacin (outpatient 79.5%, inpatient 65.9%) and trimethoprim/sulfamethoxazole (outpatient 75.2%, inpatient 73.5%). The percentage of E. coli isolates that were phenotypically positive for ESBL production significantly increased from 4.2% (2009–11) to 11.3% (2018–20). A similar although less pronounced temporal trend was observed with ESBL-producing K. pneumoniae. Conclusions E. coli was the pathogen most frequently recovered from the urine of Canadian patients, and the proportion of isolates that were ESBL producers increased over time. Susceptibility data presented here suggest that ciprofloxacin and trimethoprim/sulfamethoxazole may be suboptimal for the empirical treatment of complicated urinary infections.
Cigarette smoking during breastfeeding in Papua New Guinea: Prevalence and demographic and socio-economic predictors

Background Cigarette smoking during breastfeeding is reported to contribute to significant changes in the composition of breast milk not only by reducing its protective features but also affecting infants’ response to breastfeeding and breast milk. However, studies on the prevalence of cigarette smoking and associated factors during breastfeeding are limited in Papua New Guinea (PNG). This study estimates the prevalence of cigarette smoking and its association with demographic and economic factors among breastfeeding women in PNG. Methods We used weighted survey data from the 2016–2018 PNG Demographic and Health Survey (PNGDHS). A weighted sample of 3,822 women who were breastfeeding during the survey were included in the study. The outcome variable in the present study is current cigarette smoking. A multiple logistic regression analysis was used to estimate the association between current cigarette smoking status and socio-demographic and economic variables of breastfeeding women. The regression analysis results were reported using adjusted odds ratios (aOR) with their respective 95% confidence intervals (CIs). Results From the weighted sample, the prevalence of cigarette smoking among breastfeeding women was 21.9%; of which 60.8% smoked daily. The mean number of cigarettes smoked in the last 24 hours preceding the survey was 6.05(SD = 5.99). Multiple logistic regression analysis revealed that breastfeeding women who were from the Momase (aOR: 2.337, CI: 1.786–3.058, p<0.001) and Highlands (AOR: 1.589, CI: 1.213–2.082, p = 0.001), had no religious affiliation (aOR: 3.665, CI: 1.235–10.877, p = 0.019), and households with daughters as household heads (aOR: 1.901, CI: 1.231–2.935, p = 0.004) and being in more than one union (aOR: 2.374, CI: 1.805–3.123, p<0.001) were significantly more likely to smoke cigarette compared to women from southern region, those affiliated to Anglican church, those with husband as household heads, and being in one union respectively. Conclusion Cigarette smoking among breastfeeding women in PNG is relatively high, and region of residence, religion, relationship to household head, and the number of unions remain independent predictors. Interventions should target the individual socio-economic and cultural contexts within which breastfeeding occurs.
Quantitative PCR from human genomic DNA: The determination of gene copy numbers for congenital adrenal hyperplasia and RCCX copy number variation

Quantitative PCR (qPCR) is used for the determination of gene copy number (GCN). GCNs contribute to human disorders, and characterize copy number variation (CNV). The single laboratory method validations of duplex qPCR assays with hydrolysis probes on CYP21A1P and CYP21A2 genes, residing a CNV (RCCX CNV) and related to congenital adrenal hyperplasia, were performed using 46 human genomic DNA samples. We also performed the verifications on 5 qPCR assays for the genetic elements of RCCX CNV; C4A, C4B, CNV breakpoint, HERV-K(C4) CNV deletion and insertion alleles. Precision of each qPCR assay was under 1.01 CV%. Accuracy (relative error) ranged from 4.96±4.08% to 9.91±8.93%. Accuracy was not tightly linked to precision, but was significantly correlated with the efficiency of normalization using the RPPH1 internal reference gene (Spearman’s ρ: 0.793–0.940, p>0.0001), ambiguity (ρ = 0.671, p = 0.029) and misclassification (ρ = 0.769, p = 0.009). A strong genomic matrix effect was observed, and target-singleplex (one target gene in one assay) qPCR was able to appropriately differentiate 2 GCN from 3 GCN at best. The analysis of all GCNs from the 7 qPCR assays using a multiplex approach increased the resolution of differentiation, and produced 98% of GCNs unambiguously, and all of which were in 100% concordance with GCNs measured by Southern blot, MLPA and aCGH. We conclude that the use of an internal (in one assay with the target gene) reference gene, the use of allele-specific primers or probes, and the multiplex approach (in one assay or different assays) are crucial for GCN determination using qPCR or other methods.
Ginsenoside protopanaxadiol protects adult retinal pigment epithelial-19 cells from chloroquine by modulating autophagy and apoptosis

Chloroquine often causes serious eye and vision problems, which are mainly mediated by lysosomotropic alteration. In this study, we investigated whether the ginsenoside protopanaxadiol relieves chloroquine-induced retinopathy by restoring lysosomotropic abnormalities in human adult retinal pigment epithelial-19 cells. Cytotoxicity was assessed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Morphological alterations in autophagosomes of adult retinal pigment epithelial-19 cells was detected using confocal microscopy. Apoptosis was examined using flow cytometry, whereas cellular reactive oxygen species levels were determined by measuring the fluorescence intensity of 5-(and-6)-carboxy-2’-7’-dichlorohydrofluorescein diacetate. Lysosomal function was assessed by measuring lysosomal pH and enzyme activity. Immunoprecipitation and western blotting analyses were performed. Adult retinal pigment epithelial-19 cells accumulated autophagosomes with fusion defects in lysosomes and reactive oxygen species formation following exposure to chloroquine. This effect trapped Beclin-1 and B-cell lymphoma 2 interfering with autophagy initiation and autophagosome development. Protopanaxadiol alleviated chloroquine-induced toxicity by modulating the interaction between Beclin-1 and Bcl-2, which was mediated by the AMP-activated protein kinase-mammalian target of rapamycin signal axis. Furthermore, autophagy and apoptosis were simultaneously controlled by protopanaxadiol via upregulation of autophagy flux and decreased reactive oxygen species formation and apoptotic protein expression. These findings suggest that protopanaxadiol is a promising treatment strategy for chloroquine-mediated retinopathy.
Children’s mobile-gaming preferences, online risks, and mental health

This study examined the relationships between children’s mobile gaming preferences, online risks, and mental health. Data were obtained from a sample of 2,702 third and fourth grade students from 16 elementary schools in Taiwan and 9 schools in China. A self-administered questionnaire was used. The mental state of the children who participated in the study was assessed using the Strengths and Difficulties Questionnaire (SDQ), while mobile gaming addiction was assessed using the short form of the Internet Gaming Disorders Scale (IGDS9-SF). The results showed that about 54% of children played mobile games with others (multi-player), while 31% played mobile games alone, and 15% did not play mobile games. Multiple logistic regression results indicated that behaviors such as participating in multi-player games, playing violent games, a poor parent-child relationship, and living in a rural area were associated with a greater risk of mobile gaming addiction. Involvement in multi-player games, playing violent games, mobile gaming addiction, and exposure to mobile violence/pornography were associated with greater risks of cyber aggression/victimization. Multiple regression results showed that being a multi-player, playing violent games, mobile gaming addiction, exposure to violence/pornography, exposure to cyber aggression/victimization, and having a poor parent-child relationship were associated with emotional and behavioral problems.
Emotional and cognitive changes surrounding online depression identity claims

As social media has proliferated, a key aspect to making meaningful connections with people online has been revealing important parts of one’s identity. In this work, we study changes that occur in people’s language use after they share a specific piece of their identity: a depression diagnosis. To do so, we collect data from over five thousand users who have made such a statement, which we refer to as an identity claim. Prior to making a depression identity claim, the Reddit user’s language displays evidence of increasingly higher rates of anxiety, sadness, and cognitive processing language compared to matched controls. After the identity claim, these language markers decrease and more closely match the controls. Similarly, first person singular pronoun usage decreases following the identity claim, which was previously previously found to be indicative of self-focus and associated with depression. By further considering how and to whom people express their identity, we find that the observed longitudinal changes are larger for those who do so in ways that are more correlated with seeking help (sharing in a post instead of a comment; sharing in a mental health support forum). This work suggests that there may be benefits to sharing one’s depression diagnosis, especially in a semi-anonymous forum where others are likely to be empathetic.
Benefits of herbal formulae containing Poria cocos (Fuling) for type 2 diabetes mellitus: A systematic review and meta-analysis

Background Poria cocos (Schw.) Wolf or Fuling is one of the top 10 most frequently prescribed herbs in China for the treatment of type 2 diabetes mellitus (T2DM). Objective The purpose of this systematic review is to determine the additional benefit of Fuling formulae use in addition to hypoglycaemic agents for T2DM in randomised clinical trials. Methods English (5) and Chinese (4) medical databases were searched from their inception to August 2021. RCTs that included Fuling in herbal formulae for T2DM were included. Risk of bias were assessed using the Cochrane Collaboration’s procedures. Stata software (13.0) was used for data analysis. Results Seventy-three RCTs (6,489 participants) with herbal formulae containing Fuling were included. Most studies were at risk of bias and strength of the evidence were low to moderate. Meta-analysis findings showed that the addition of formulae containing Fuling to hypoglycaemic agent-treatments could benefit people with T2DM by reducing fasting blood glucose (MD -0.82 [-0.93, -0.71]; I2 = 79.6%, P = 0.00), 2-hour postprandial blood glucose (MD-1.15 [-1.31, -0.98], I2 = 80%, P = 0.00) and haemoglobin A1c (MD-0.64 [-0.75, -0.53], I2 = 84.7%, P = 0.00). Adverse events were also significantly lower in the integrative group than in the hypoglycaemic alone group (RR 0.99 [0.93, 1.06], P = 0.87). Conclusion Evidence from this study supports the use of Fuling formulae combined with hypoglycaemic agents for T2DM. The combined therapies appear to be well tolerated. Trail registration This review is registered with the PROSPERO international prospective register of systematic reviews (CRD42020214635).
Analysis of residual disease in periocular basal cell carcinoma following hedgehog pathway inhibition: Follow up to the VISORB trial

Basal cell carcinoma (BCC) is a common skin cancer caused by deregulated hedgehog signaling. BCC is often curable surgically; however, for orbital and periocular BCCs (opBCC), surgical excision may put visual function at risk. Our recent clinical trial highlighted the utility of vismodegib for preserving visual organs in opBCC patients: 67% of patients displayed a complete response histologically. However, further analysis of excision samples uncovered keratin positive, hedgehog active (Gli1 positive), proliferative micro-tumors. Sequencing of pre-treatment tumors revealed resistance conferring mutations present at low frequency. In addition, one patient with a low-frequency SMO W535L mutation recurred two years post study despite no clinical evidence of residual disease. Sequencing of this recurrent tumor revealed an enrichment for the SMO W535L mutation, revealing that vismodegib treatment enriched for resistant cells undetectable by traditional histology. In the age of targeted therapies, linking molecular genetic analysis to prospective clinical trials may be necessary to provide mechanistic understanding of clinical outcomes. Trial Registration: ClinicalTrials.gov Identifier: NCT02436408.
Antheraea peptide and its analog: Their influence on the maturation of the reproductive system, embryogenesis, and early larval development in Tenebrio molitor L. beetle

In recent years, many new immunologically active peptides from insects have been identified. Unfortunately, in most cases, their physiological functions are not fully known. One example is yamamarin, a pentapeptide isolated from the caterpillars of the Antheraea yamamai moth. This peptide has strong antiproliferative properties and is probably involved in the regulation of diapause. Additionally, antiviral activity was discovered. The results of the research presented in this paper are, to our knowledge, the first attempt to characterize the biological effects of yamamarin on the functioning of the reproductive processes and embryonic development of insects using a model species, the beetle Tenebrio molitor, a commonly known pest of grain storage. Simultaneously, we tested the possible activity of the molecule in an in vivo system. In this research, we present the multifaceted effects of yamamarin in this beetle. We show that yamamarin influences ovarian growth and development, maturation of terminal oocytes, level of vitellogenin gene transcript, the number of laid eggs, duration of embryonic development, and larval hatching. In experiments with palmitic acid-conjugated yamamarin (C16-yamamarin), we also showed that this peptide is a useful starting molecule for the synthesis of biopharmaceuticals or new peptidomimetics with gonadotropic activity and effects on embryonic development. The data obtained additionally provide new knowledge about the possible function of yamamarin in insect physiology, pointing to the important role of this pentapeptide as a regulator of reproductive processes and embryonic development in a heterologous bioassay with T. molitor.
Acoustic Trauma in the Guinea Pig

The ears of anesthetized guinea pigs were exposed to intense tones of 135, 545, 2000, or 8000 cps at sound pressures (at the eardrum) from 138 to 148 db re 0.0002 microbar. The electrical output was recorded by differential intracochlear electrodes before, during, and after the exposures.The injury caused by 8000 cps centers in the basal turn, by 2000 cps in the second turn, by 500 and 185 cps in the third and fourth turns of the cochlea. No single tone, at the intensities and durations employed, injured all of the cochlea.The “threshold” and also the maximum voltage of the cochlear microphonic are valid indices of the anatomical injury seen under the microscope if the proper test frequencies and positions of electrodes are used.The destructiveness of a tone does not depend on its frequency. Equally severe (probably permanent) injuries were produced by a one‐minute exposure at all four frequencies tested when the intensity level was about 144 db at the eardrum.
Action of a force near the planar surface between two semi-infinite immiscible liquids at very low Reynolds numbers

Explicit expressions for the Green's functions due to a point force in one of two half space fluids are presented for the case when inertial effects of the fluid are negligible (Stokes flow) and the interface between the two fluids is considered to be flat due to the action of surface tension. The analytic expressions are discussed in terms of singularity diagrams. For the case of a force parallel to the interface a first approximation to the interface displacement is made.
Exact quantum phase model for mesoscopic Josephson junctions

Starting from the two-mode Bose-Hubbard model, we derive an exact version of the standard Mathieu equation governing the wave function of a Josephson junction. For a finite number of particles N, we find an additional cos 2 phi term in the potential. We also find that the inner product in this representation is nonlocal in phi. Our model exhibits phenomena, such as pi oscillations, which are not found in the standard phase model, but have been predicted from Gross-Pitaevskii mean-field theory.
Random field Ising model on the Bethe lattice

Low-temperature series expansions have been derived for the random field Ising model with a delta -function distribution on a Bethe lattice by two independent methods: (a) the finite-cluster method which uses graph embeddings and appropriate weighting functions; (b) the use of a recursion relation specific to the Bethe lattice. Numerical values have been evaluated when the coordination number q=3, 4 and the coefficients analysed to assess critical behaviour. For small fields, and temperatures near to Tco, the critical exponent of the magnetisation seems to retain its mean-field value. But there is clear evidence of a change in critical behaviour at some point on the critical curve. It is argued that when q>3 a tricritical point is indicated as found by Aharony in his mean-field solution.