Miracle-dz/UniFAR-FTUs huggingface dataset:
Mesenchymal Stromal Cell Mitochondrial Transfer as a Cell Rescue Strategy in Regenerative Medicine: A Review of Evidence in Preclinical Models

Abstract Mesenchymal stromal cells (MSC) have excellent clinical potential and numerous properties that ease its clinical translation. Mitochondria play a crucial role in energy metabolism, essential for cellular activities, such as proliferation, differentiation, and migration. However, mitochondrial dysfunction can occur due to diseases and pathological conditions. Research on mitochondrial transfer from MSCs to recipient cells has gained prominence. Numerous studies have demonstrated that mitochondrial transfer led to increased adenosine triphosphate (ATP) production, recovered mitochondrial bioenergetics, and rescued injured cells from apoptosis. However, the complex mechanisms that lead to mitochondrial transfer from healthy MSCs to damaged cells remain under investigation, and the factors contributing to mitochondrial bioenergetics recovery in recipient cells remain largely ambiguous. Therefore, this review demonstrates an overview of recent findings in preclinical studies reporting MSC mitochondrial transfer, comprised of information on cell sources, recipient cells, dosage, route of administration, mechanism of transfer, pathological conditions, and therapeutic effects. Further to the above, this research discusses the potential challenges of this therapy in its clinical settings and suggestions to overcome its challenges.
Treatment potential in APOL1-associated nephropathy

Purpose of review More than 5 million African–Americans, and millions more in Africa and worldwide, possess apolipoprotein L1 gene (APOL1) high-risk genotypes with an increased risk for chronic kidney disease. This manuscript reviews treatment approaches for slowing the progression of APOL1-associated nephropathy. Recent findings Since the 2010 discovery of APOL1 as a cause of nondiabetic nephropathy in individuals with sub-Saharan African ancestry, it has become apparent that aggressive hypertension control, renin-angiotensin system blockade, steroids and conventional immunosuppressive agents are suboptimal treatments. In contrast, APOL1-mediated collapsing glomerulopathy due to interferon treatment and HIV infection, respectively, often resolve with cessation of interferon or antiretroviral therapy. Targeted therapies, including APOL1 small molecule inhibitors, APOL1 antisense oligonucleotides (ASO) and inhibitors of APOL1-associated inflammatory pathways, hold promise for these diseases. Evolving therapies and the need for clinical trials support the importance of increased use of APOL1 genotyping and kidney biopsy. Summary APOL1-associated nephropathy includes a group of related phenotypes that are driven by the same two genetic variants in APOL1. Clinical trials of small molecule inhibitors, ASO, and inflammatory pathway inhibitors may improve outcomes in patients with primary forms of APOL1-associated nephropathy.
Catheter ablation for patients with atrial fibrillation and heart failure with reduced and preserved ejection fraction: insights from the KiCS-AF multicentre cohort study

Abstract Aims The usefulness of catheter ablation (CA) for atrial fibrillation (AF) across a broad spectrum of heart failure (HF) patients remains to be established. We assessed the association of CA with both health-related quality of life (QoL) and cardiovascular events among HF patients with reduced and preserved left ventricular ejection fraction (LVEF) in an ‘all-comer’ outpatient-based AF registry. Methods and results Of 3303 patients with AF consecutively enrolled in a retrospective multicentre registry that mandated the Atrial Fibrillation Effect on QualiTy-of-life (AFEQT) questionnaire at registration and 1-year follow-up, we extracted data from 530 patients complicating clinical HF. The association between CA and both 1-year change in AFEQT Overall Summary (AFEQT-OS) scores and 2-year composite clinical outcomes (including all-cause death, stroke, and HF hospitalization) was assessed by multivariable analyses. The median duration of AF was 108 days (52–218 days), and 83.4% had LVEF >35%. Overall, 75 patients (14.2%) underwent CA for AF within 1-year after registration. At 1-year follow-up, 67.2% in the ablation group showed clinically meaningful improvements of ≥ 5 points in AFEQT-OS score than 47.8% in the non-ablation group {adjusted odds ratio, 2.03 [95% confidence interval (CI): 1.13–3.64], P = 0.017}. Furthermore, the composite endpoint of all-cause death, stroke, and HF hospitalization occurred less frequently in the ablation group than the non-ablation group [adjusted hazard ratio, 0.27 (95% CI: 0.09–0.86), P = 0.027]. Conclusion Among AF-HF patients, CA was associated with improved QoL and lower risk of cardiovascular events against drug therapy alone, even for patients with mildly reduced and preserved LVEF.
Defining effective durations of antibiotic therapy for community-acquired pneumonia and urinary tract infections in hospitalized children

Purpose of review Community-acquired pneumonia (CAP) and urinary tract infections (UTI) are two common childhood infections often leading to hospital admission. National guidelines for CAP and UTI in children recommend durations of antibiotic therapy of 10 days and 7–14 days, respectively. Due to concerns of rising antimicrobial resistance and an increased awareness of harms associated with prolonged courses of antibiotics, there is a renewed emphasis on reevaluating commonly prescribed durations of antibiotic therapy across bacterial infections. We describe recent clinical trials and observational studies evaluating durations of therapy for CAP and UTI in adults and children and translate the findings to our suggested approach for selecting durations of antibiotic therapy in hospitalized children. Recent findings There is a growing body of evidence, primarily in adults, that shorter durations of therapy than are commonly prescribed are just as effective as longer durations for CAP and UTIs. Summary Combining clinical trial data from adults with available data in children, we believe it is reasonable to consider 5 days of therapy for CAP, 3–5 days of therapy for cystitis, and 7 days of therapy for pyelonephritis for most hospitalized children with uncomplicated infections.
Treatment of persistent large cystic lesions of the humerus with vascularized fibular grafts

Objectives In this study, we aimed to evaluate the short-to-midterm results of the resection and reconstruction of large cystic lesions of the humerus. Patients and methods Eight male patients (median age: 22.9±10.4 years; range, 12 to 42 years) with large cystic lesions of the humerus operated between January 2017 and December 2019 were retrospectively analyzed. The age of the patients, their previous treatments and follow-up periods, the size and location of the cysts, postoperative functional scores, presence of a union, recurrence of the cyst, and graft resorption were examined. Results The mean follow-up was 42.8±7.5 (range, 34 to 54) months. Preoperatively, the mean length of the cystic lesions was 15.1±2.6 (range, 10 to 18) cm. At the final follow-up, the patients had a normal range of shoulder flexion-extension, internal rotation-external, abduction-adduction, and elbow flexion-extension, pronation-supination. The patients had a mean DASH score of 1.13±1.1 (range, 0 to 3.3) and MSTS score of 28.75±1.8 (range, 26 to 30) postoperatively. Complications such as pseudoarthrosis, graft resorption, or cyst recurrence were not observed in any of the patients. Conclusion Although the risk of recurrence is low in small cystic lesions of the humerus, it increases as the size of the lesion increases. This reconstruction technique using vascularized fibular grafts, which we applied, seems to be extremely successful in ensuring biological healing and preventing recurrence and complications in patients with large cystic lesions of the humerus.
Optimized design of an arterial network model reproduces characteristic central and peripheral haemodynamic waveform features of young adults

The arterial network in healthy young adults is thought to be structured to optimize wave reflection in the arterial system, producing an ascending aortic pressure waveform with three key features: early systolic peak, negative systolic augmentation and diastolic hump. One‐dimensional computer models have provided significant insights into arterial haemodynamics, but no previous models of the young adult have exhibited these three features. Given that this issue was likely to be related to unrepresentative or non‐optimized impedance properties of the model arterial networks, we developed a new ‘YoungAdult’ model that incorporated the following features: (i) a new and more accurate empirical equation for approximating wave speeds, based on area and relative distance to elastic–muscular arterial transition points; (ii) optimally matched arterial junctions; and (iii) an improved arterial network geometry that eliminated ‘within‐segment’ taper (which causes wave reflection in conduit arteries) whilst establishing ‘impedance‐preserving’ taper. These properties of the model led to wave reflection occurring predominantly at distal vascular beds, rather than in conduit arteries. The model predicted all three typical characteristics of an ascending aortic pressure waveform observed in young adults. When compared with non‐invasively acquired pressure and velocity measurements (obtained via tonometry and Doppler ultrasound in seven young adults), the model was also shown to reproduce the typical waveform morphology observed in the radial, brachial, carotid, temporal, femoral and tibial arteries. The YoungAdult model provides support for the concept that the arterial tree impedance in healthy young adults is exquisitely optimized, and it provides an important baseline model for investigating cardiovascular changes in ageing and disease states.
Proposal of a Method for Harmonized Broth Microdilution Antimicrobial Susceptibility Testing of Avibacterium gallinarum

Avibacterium (Av.) gallinarum is an opportunistic pathogen in poultry, which, however, has also been associated with human disease. There is currently no approved method for antimicrobial susceptibility testing of this pathogen, so this study aimed at developing a harmonized broth microdilution method for Av. gallinarum that is suitable for diagnostic laboratories. ABSTRACT Avibacterium (Av.) gallinarum is an opportunistic pathogen in poultry, which, however, has also been associated with human disease. There is currently no approved method for antimicrobial susceptibility testing of this pathogen, so this study aimed at developing a harmonized broth microdilution method for Av. gallinarum that is suitable for diagnostic laboratories. For this, the Av. gallinarum CCUG 12391T type strain and 42 field isolates were collected and their species was confirmed by using a species-specific PCR assay and biochemical reactions. To select epidemiologically unrelated isolates, ApaI macrorestriction analysis was performed. Preliminary growth experiments were conducted with six culture media, and based on the results, four media were selected to compile growth curves with four isolates. Independent repetitions of MIC determinations were then performed to evaluate the reproducibility of the values. Cation-adjusted Mueller-Hinton broth (CAMHB) was initially selected as broth medium, but did not show sufficient homogeneity of MICs. Therefore, CAMHB plus 1% chicken serum and 0.0025% NADH was selected and showed a good homogeneity of MICs after 20 h and 24 h of incubation at 35 ± 2°C. This was reflected in essential MIC agreements ranging between 96% and 100%. Testing of a larger Av. gallinarum collection (n = 43) revealed that easily readable MICs could be obtained for the type strain and all isolates. Some Av. gallinarum showed elevated MICs of enrofloxacin (n = 35), nalidixic acid (n = 35), penicillin (n = 2), tetracycline (n = 19), and/or trimethoprim-sulfamethoxazole (n = 1). By using PCR analyses, the following antimicrobial resistance genes were detected: blaTEM, dfrA14, sul2, tet(B), tet(H). The study demonstrated that the proposed medium is suitable for a harmonized broth microdilution susceptibility testing of Av. gallinarum with a recommended incubation time of 20 to 24 h.
Designing optimal speed control with observer using integrated battery-electric vehicle (IBEV) model for energy efficiency

This paper develops an optimal speed control using a linear quadratic integral (LQI) control standard with/without an observer in the system based on an integrated battery-electric vehicle (IBEV) model. The IBEV model includes the dynamics of the electric motor, longitudinal vehicle, inverter, and battery. The IBEV model has one state variable of indirectly measured and unobservable, but the system is detectable. The objectives of this study were: (a) to create a speed control that gets the exact solution for a system with one indirect measurement and unobservable state variable; and (b) to create a speed control that has the potential to make a more efficient energy system. A full state feedback LQI controller without an observer is used as a benchmark. Two output feedback LQI controllers are designed; including one controller uses an order-4 observer and the other uses an order-5 observer. The order-4 observer does not include the battery state of charge as an observer state whereas the order-5 observer is designed by making all the state variable as the observer state and using the battery state of charge as an additional system output. An electric passenger minibus for public transport with 1500 kg weight was used as the vehicle model. Simulations were performed when the vehicle moves in a flat surface with the increased speed from stationary to 60 km/h and moves according to standard NEDC driving profile. The simulation results showed that both the output feedback LQI controllers provided similar speed performance as compared to the full state feedback LQI controller. However, the output feedback LQI controller with the order-5 observer consumed less energy than with the order-4 observer, which is about 10% for NEDC driving profile and 12% for a flat surface. It can be concluded that the LQI controller with order-5 observer gives better energy efficiency than the LQI controller with order-4 observer
Micromagnetic simulation of neutron scattering from spherical nanoparticles: Effect of pore-type defects

We employ micromagnetic simulations to model the eﬀect of pore-type microstructural defects on the magnetic small-angle neutron scattering cross section and the related pair-distance distribution function of spherical magnetic nanoparticles. Our expression for the magnetic energy takes into account the isotropic exchange interaction, the magnetocrystalline anisotropy, the dipolar interaction, and an externally applied magnetic ﬁeld. The signatures of the defects and the role of the dipolar energy are highlighted and the eﬀect of a particle-size distribution is studied. The results serve as a guideline to the experimentalist.
Implementing and Breaking Load-Link / Store-Conditional on an ARM-Based System

Manufacturers of modern electronic devices are constantly attempting to implement additional features into ever-increasingly complex and performance demanding systems. This race has been historically driven by improvements in the processor's clock speed, but as power consumption and real estate concerns in the embedded space pose an growing challenge, multithreading approaches have become more prevalent and relied upon. Synchronization is essential to multithreading systems, as it ensures that threads do not interfere with each others' operations and produce reliable and consistent outputs whilst maximizing performance and efficiency. One of the primary mechanisms guaranteeing synchronization in RISC architectures is the load-link/store conditional routine, which implements an atomic operation that allows a thread to obtain a lock. In this study, we implement, test, and manipulate an LL/SC routine in a multithreading environment using GDB. After examining the routine mechanics, we propose a concise implementation in ARMv7l, as well as demonstrate the importance of register integrity and vulnerabilities that occur when integrity is violated under a limited threat model. This work sheds light on LL/SC operations and related lock routines used for multithreading.
Weak gravitational flexion in various spacetimes: Exotic lenses and modified gravity

Exotic objects such as the Ellis wormhole are expected to act as gravitational lenses. Much like their nonexotic counterparts, information about these lenses can be found by considering the strong and weak lensing fields they induce. In this work, we consider how weak gravitational lensing flexion can provide information beyond that of shear. We find that directional flexion can distinguish between the case of a positive or negative convergence where directional shear cannot, and therefore can provide a unique lensing signature for objects with an Ellis wormhole-type metric. We also consider cosmic flexion, the flexion correlation function whose signal originates from the large-scale structure of the Universe, in the context of modified gravity. We find flexion to be a unique probe of parametric models of modified gravity, particularly in the case of scale-dependent phenomenological post-general relativity functions.
Regret Minimization with Noisy Observations

In a typical optimization problem, the task is to pick one of a number of options with the lowest cost or the highest value. In practice, these cost/value quantities are often not accurately known: they can come from physical measurements with imperfect tools, estimations of machine learning algorithms, or observations from differentially private mechanisms. In many of these situations, the cost/value quantities are noisy, but with quantifiable noise distributions. To take these noise distributions into account, one approach is to assume a prior distribution for the values, use it to build a posterior, and then apply standard stochastic optimization to pick a solution. However, in many practical applications, such prior distributions may not be available. In this paper, we study such scenarios using a regret minimization model.
Wreath Products and Projective System of non-Schurian Association Schemes

A wreath product is a method to construct an association scheme from two association schemes. We determine the automorphism group of a wreath product. We show a known result that a wreath product is Schurian if and only if both components are Schurian, which yields large families of non-Schurian association schemes and non-Schurian $S$-rings. We also study iterated wreath products. Kernel schemes by Martin and Stinson are shown to be iterated wreath products of class-one association schemes. The iterated wreath products give examples of projective systems of non-Schurian association schemes, with an explicit description of primitive idempotents.
Phase-Shifted Full-Bridge DC–DC Converter With High Efficiency and High Power Density Using Center-Tapped Clamp Circuit for Battery Charging in Electric Vehicles

In this paper, a phase-shifted full-bridge (PSFB) converter employing a new center-tapped clamp circuit is proposed to achieve high efficiency and high power density in electric-vehicle battery charger applications. By using a simple center-tapped clamp circuit, which consists of two diodes and one capacitor, many limitations in conventional PSFB converters are solved. The proposed center-tapped clamp circuit provides the clamping path and allows the secondary voltage stress to be clamped to the secondary-reflected input voltage. This results in a greatly reduced conduction loss in the secondary full-bridge rectifier (FBR) due to the low-forward-voltage drop of low-voltage-rated diodes, and the resistor–capacitor–diode snubber loss is eliminated. In addition, the circulating current in the primary side is removed without any duty-cycle loss. Furthermore, the turn-off switching loss in the FBR is substantially reduced due to the decreased reverse-recovery current and the reduced reverse voltage. With these advantages, high efficiency can be achieved. Besides, the size of the output inductor is considerably reduced with the aid of clamping voltage, resulting in a high power density with saving the cost. In order to confirm the effectiveness of the proposed converter, a 3.3-kW prototype was tested. Experimental results show that the proposed converter achieves high efficiency over the entire conditions with high power density.
Gaia Spectroscopic Orbits Validated with LAMOST and GALAH Radial Velocities

The recently published Gaia DR3 catalog of 181327 spectroscopic binaries (SB) includes the Keplerian elements of each orbit but not the measured radial velocities (RVs) and their epochs. Instead, the catalog lists a few parameters that characterize the robustness of each solution. In this work, we use two external sources to validate the orbits - 17563 LAMOST DR6 and 6018 GALAH DR3 stars with measured RVs that have Gaia-SB orbits. We compare the expected RVs, based on the Gaia orbits, with the LAMOST and GALAH measurements. Finding some orbits that are inconsistent with these measurements, we constructed a function that estimates the probability of each of the Gaia orbits to be correct, using the published robust parameters. We devise a clean but still very large Gaia SB1 sample of 91740 orbits. The sample differs from the parent sample by the absence of - physically unlikely and hence presumably spurious - short-period binaries with high eccentricity. The clean SB1 sample offers the prospect of thorough statistical studies of the binary population after carefully modeling of the remaining selection effects. At a first look, two possible features emerge from the clean sample - a paucity of short-period binaries with low-mass primaries, which might be a result of some observational bias, and a sub-sample of main-sequence binaries on circular orbits, probable evidence for circularization processes.
Diamond Integrated Quantum Photonics: A Review

—Integrated quantum photonics devices in diamond have tremendous potential for many quantum applications, including long-distance quantum communication, quantum infor- mation processing, and quantum sensing. These devices beneﬁt from diamond’s combination of exceptional thermal, optical, and mechanical properties. Its wide electronic bandgap makes diamond an ideal host for a variety of optical active spin qubits that are key building blocks for quantum technologies. In landmark experiments, diamond spin qubits have enabled demon- strations of remote entanglement, memory-enhanced quantum communication, and multi-qubit spin registers with fault-tolerant quantum error correction, leading to the realization of multinode quantum networks. These advancements put diamond at the forefront of solid-state material platforms for quantum information processing. Recent developments in diamond nanofabrication techniques provide a promising route to further scaling of these landmark experiments towards real-life quantum technologies. In this paper, we focus on the recent progress in creating integrated diamond quantum photonic devices, with particular emphasis on spin-photon interfaces, cavity optomechanical devices, and spin-phonon transduction. Finally, we discuss prospects and remaining challenges for the use of diamond in scalable quantum technologies.