Miracle-dz/UniFAR-FTUs huggingface dataset:
Nanotechnology: A new frontier in Agriculture

Nanotechnology is science of manipulating materials at nano-scale. Among the latest technological advancements, nanotechnology occupies a central position. It has many applications in all stages of production, processing, storing, packaging and transport of agricultural products. The reduced use of herbicides, pesticides and fertilizers with increased efficiency, controlled release and targeted delivery will lead to precision farming. Dream of automated, centrally controlled agriculture can become reality now. Modern agriculture is need of hour because conventional agricultural will not be able to feed an ever increasing population with changing climate, depleting resources and shrinking landscape. But at the same time application of nano-materials in agri-food sector has to be evaluated for public acceptance so it does not come across a scenario as faced by GMOs in past. This article provides an overview of current and potential applications of nanotechnology in agriculture and food sector.
A Systematic Review on Viruses in Mass-Reared Edible Insect Species

Edible insects are expected to become an important nutrient source for animals and humans in the Western world in the near future. Only a few studies on viruses in edible insects with potential for industrial rearing have been published and concern only some edible insect species. Viral pathogens that can infect insects could be non-pathogenic, or pathogenic to the insects themselves, or to humans and animals. The objective of this systematic review is to provide an overview of the viruses detected in edible insects currently considered for use in food and/or feed in the European Union or appropriate for mass rearing, and to collect information on clinical symptoms in insects and on the vector role of insects themselves. Many different virus species have been detected in edible insect species showing promise for mass production systems. These viruses could be a risk for mass insect rearing systems causing acute high mortality, a drastic decline in growth in juvenile stages and in the reproductive performance of adults. Furthermore, some viruses could pose a risk to human and animal health where insects are used for food and feed.
Corporate Code of Conduct: A Kantian Opportunity

The moral issues that occur for for-profit corporations are a unique function of many internal and external factors, including corporate policies and purpose, business regulations, and business governance’s economic and political system. Several possible theoretical frameworks prescribe behavioral norms and standards of conduct to companies, such as utilitarianism, deontological ethics, or virtue ethics. In this paper, we argue although there are significant similarities between Kantian Ethics and ideal corporate cultures, Kantian ethics cannot fully integrated into contemporary corporate practices. Kant’s theory of morality fundamentally fails to accommodate the infamous given purpose of corporations, namely to seek profit. We also provide confirming empirical insights from a case study in developing a semi-Kantian corporate code of conduct for a large technology-based company in Iran.
Risk factors for in-hospital death in acute ST-segment elevation myocardial infarction after emergency percutaneous coronary intervention: a multicenter retrospective study.

BACKGROUND For some acute ST-segment elevation myocardial infarction (STEMI) cases, the risk of in-hospital death remains high even after emergency percutaneous coronary intervention (PCI). This study sought to identify predictors of in-hospital mortality in STEMI patients after PCI. METHODS Patients with acute STEMI, who underwent emergency PCI at Hebei General Hospital, Baoding First Central Hospital, and Cangzhou Central Hospital, from January 2016 to December 2018, were retrospectively included in this study. The patients' general data, previous medical history, clinical data and medication data were collected and compared between the survival and mortality groups. The primary outcome was in-hospital mortality. In-hospital mortality was defined as all-cause death during admission. RESULTS Of the 1,169 patients (876 male and 293 female) enrolled in this study, 95 (8.13%) died during hospitalization. The multivariate logistic regression analysis showed that being female [odds ratio (OR) =5.86, 95% confidence interval (CI): 2.03-16.92, P=0.001], a Killip class of 2 (OR =8.13, 95% CI: 2.03-32.61, P=0.003), a Killip class of 4 (OR =17.31, 95% CI: 3.69-81.27, P=0.001), a left main coronary artery lesion (OR =44.25, 95% CI: 3.96-494.05, P=0.002), a final TIMI flow of 1 (OR =171.83, 95% CI: 28.46-1037.51, P=0.001), a final TIMI flow of 2 (OR =72.93, 95% CI: 38.54-138.00, P=0.001), symptom onset-to-door time (SDT) (OR =1.01, 95% CI: 1.00-1.02, P=0.001), symptom onset-to-balloon dilatation time (SBT) (OR =1.01, 95% CI: 1.00-1.02, P=0.001), and the Synergy Between PCI With Taxus and CABG (SYNTAX) score (OR =1.07, 95% CI: 1.01-1.12, P=0.019) were risk factors; while postoperative β-receptor blockers (OR =0.10, 95% CI: 0.03-0.30, P=0.001) postoperative angiotensin-converting enzymes/angiotensin receptor blockers (OR =0.13, 95% CI: 0.04-0.44, P=0.001), BMI (OR =0.85, 95% CI: 0.74-0.98, P=0.024), the percentage of the ejection fraction (OR =0.81, 95% CI: 0.75-0.86, P=0.001), and low-density lipoprotein cholesterol (OR =0.44, 95% CI: 0.21-0.91, P=0.027) were protective factors for in-hospital mortality. CONCLUSIONS Female, Killip grade, a left main lesion, TIMI grade, SDT, SBT, and SYNTAX score were associated with a higher risk of in-hospital death. Conversely, BMI, ejection fraction, LDL-C level, and postoperative use of β-blocker and ACEI/ARB drugs were associated with a lower in-hospital death risk.
Preprint paper platforms in the academic scholarly communication environment

Academic scholarly communication is the predominant business of researchers, scientists, and scholars. It is the core element of promoting scientific thought, investigation, and building up solid knowledge. The development of preprint platform web interfaces, server repositories of electronic scholarly papers submitted by their authors and openly available to the scientific community proposed a new form of academic communication. The distribution of a preprint of a scientific manuscript allows the authors to claim the priority of discovery, in a manner similar to the conference proceedings output, but also creates an anteriority that prevents protection by a patent application. Herein, we review the scope and the role of preprint papers platforms in academia, we explore individual cases, arXiv, SSRN, OSF Preprints, HAL, bioRxiv, EconStor, RePEc, PhilArchive, Research Square, viXra, Cryptology ePrint Archive, Preprints.org, ChinaXiv, medRxiv, JMIR Preprints, Authorea, ChemRxiv, engrXiv, e-LiS, SciELO, PsyArXiv, F1000 Research, and Zenodo, and discuss their significance in promoting scientific discovery, the potential risks of scientific integrity, as well as the policies of data distribution and intellectual property rights, the plus and minus, for the stakeholders, authors, institutions, states, scientific journals, scientific community, and the public. In this review we explore the scope and policies of the existing preprint papers platforms in different academic research fields.
Primordial black holes and gravitational waves in nonstandard cosmologies

For primordial black holes (PBHs) to form a considerable fraction of cold dark matter, the required amplitude of primordial scalar perturbations is quite large ($P_{\zeta}(k) \sim 10^{-2}$) if PBH is formed in radiation epoch. In alternate cosmological histories, where additional epoch of arbitrary equation of state precede radiation epoch, the dynamics of PBH formation and relevant mass ranges can be different leading to lower requirement of primordial power at smaller scales of inflation. Moreover, this alternate history can modify the predictions for the gravitational wave (GW) spectrum, which can be probed by upcoming GW observations. In this paper, we show that an early kination epoch can lead to per cent level abundance ofPBH for a lower amplitude of $P_{\zeta}(k)$ compared to PBH formation in a standard radiation epoch. Moreover, we calculate the effect of early kination epoch on the GW spectrum for first and second orders in perturbation theory which show enhancement in the amplitude of the GW spectrum in a kination epoch with respect to that in a standard radiation epoch.
Silk-based bilayered small diameter woven vascular conduits for improved mechanical and cellular characteristics

Abstract A major impediment to the development of small diameter vascular grafts is to achieve an optimal balance between its mechanical properties and cellular response. To address this, the technique of cylindrical weaving has been combined with electrospinning to fabricate a seamless bilayered conduit (∼3 mm) having an inner cell-friendly nanofibrous layer of poly(caprolactone)/collagen and an outer mechanically compliant woven silk layer. Mechanical characteristics such as burst strength, suture retention, compliance and leak resistance were found to be improved for this bilayered conduit when compared to the commercial standard. In-vitro studies revealed that the lumen of the conduit was non-hemolytic and could support adhesion and viability of endothelial cells. Overall, our studies suggest that the proposed bilayer construct could be a suitable candidate for small diameter vascular prosthesis. Graphical Abstract
A holistic view of knowledge integration in collaborative supply chains

New product development (NPD) projects offer a unique opportunity to examine knowledge integration themes in a collaborative network. We propose a finer grained view of knowledge integration mechanisms in collaborative supply chains. Specifically, we propose two different types of mechanisms that are in play within a collaborative supply chain; short-term knowledge sharing and iterative knowledge enrichment. Using data from a large and diverse set of 432 NPD projects, we investigate the effects of knowledge sharing and enrichment between firms and their collaborative network partners, on product concept effectiveness and process performance. Our findings suggest that knowledge sharing and enrichment are significant mechanisms for enterprise-wide knowledge integration in collaborative networks. In addition, upstream knowledge sharing and enrichment has a significant influence on both product concept effectiveness and manufacturing process performance, over and above the effects of downstream knowledge sharing and enrichment. The relationship of upstream and downstream knowledge sharing and enrichment on product concept effectiveness and process performance had varying effects based on the contexts of product type, stage in the product life cycle and project size, indicating a context-specific influence of knowledge strategies. The implication of our results on academic theory and managerial practice is offered.
FORMULATION, OPTIMIZATION AND EVALUATION OF MATRIX TYPE TRANSDERMAL DRUG DELIVERY SYSTEM OF ANTIEMETIC DRUG USING ESSENTIAL OILS AND NON-IONIC SURFACTANT AS PERMEATION ENHANCERS

This study involved developing a matrix-type transdermal therapeutic system comprising of ondansetron hydrochloride with 7:3 ratio of hydrophilic and hydrophobic polymeric combinations using solvent evaporation technique. The effects of permeation enhancers were studied at the concentrations of 2.5% and 5% using essential oils such as menthol oil, eucalyptus oil, clove oil, lemon grass oil and the blend of best volatile oil with Tween 20 dibutyl phthalate and glycerin were used as plasticizers. Formulated patches were evaluated for thickness, folding endurance, drug content, percent moisture absorption, percent moisture loss, tensile strength and water vapour transmission rate. There was no physicalchemical incompatibility between the drug and the polymers. The results of in vitro drug release studies showed that the blend of menthol oil and Tween 20 exhibited maximum release. The optimized formulation was found to be stable during the stability studies. The developed transdermal patches increase the efficacy and improve the bioavailability.
A management tool for innovation using systems thinking approach

This paper presents a model, which allows managers to identify the influence of their decisions to the potential innovation activity of the firm by simulation. Systems thinking methodology has been used to understand the framework of innovation systems and to design and run the simulation model. The model is based on two separate subsystems the 'creative factory' and the 'supply availability' that illustrate the internal and external framework of a firm. This paper however presents the sub-model that refers to the 'creative factory' and the managers' decisions that affect the new product design and development process. Using this model a company can evaluate its ability to create new products and processes. The managers can test their decisions against the implications for the innovation activity of the firm and they can design scenarios that can sustain or enhance the production of new products and processes.
FPGA-based adaptive backstepping control system using RBFN for linear induction motor drive

A field-programmable gate array (FPGA)-based adaptive backstepping control system with radial basis function network (RBFN) observer is proposed to control the mover position of a linear induction motor (LIM). First, the indirect field-oriented mechanism is adopted for controlling the LIM. Next, a backstepping control law is designed step by step for the tracking control of periodic reference trajectories, in which the uncertainties are lumped by a conservative constant. However, the lumped uncertainty is unknown and difficult to obtain in advance in practical applications. Therefore an RBFN is derived to observe the lumped uncertainty in real-time, and an adaptive backstepping control system with RBFN observer is resulted. Then, an FPGA chip is adopted to implement the indirect field-oriented mechanism and the developed control algorithms for possible low-cost, high-performance industrial applications. The effectiveness of the proposed control scheme is verified by some simulated and experimental results. By using the adaptive backstepping control system with RBFN observer, the FPGA-based LIM drive possesses the advantages of good transient control performance and robustness to uncertainties in the tracking of periodic reference trajectories.
Wintertime Submesoscale Offshore Events Overcoming Wind‐Driven Onshore Currents in the East China Sea

Coastal offshore currents transport terrestrial materials from coastal areas to continental shelf areas in the upper layer; these currents are regarded as unimportant in winter when wind‐driven onshore currents are dominant. In this paper, both long‐term observations and high‐resolution simulations in the East China Sea reveal unique wintertime offshore currents in the upper layer that are widespread in the 30–70‐m isobath area and even overcome the wind‐driven onshore currents at the 50–70‐m isobaths. The mixed layer instabilities, frontogenesis and turbulent thermal wind, which constitute a mechanism in the generation of submesoscale offshore currents, have a growth rate that is fast enough to compete with the wind‐driven dynamics when the winter monsoon is relatively weak (<10 m/s). The alternation of the weak‐wind and strong‐wind modes during the winter monsoons provides a general condition for the repeated occurrence of remarkable submesoscale cross‐shore transport and carbon sequestration in coastal seas.
Desgin and control studies of a linear synchronous motor for urban transit application

Magnetic circuit analysis is used for a design study of an iron-cored homopolar linear synchronous motor (LSM) for urban transit application. Using a suitable field or current angle, efficiency, power factor, and ratio of output power to total voltamps input are all calculated to be better than 85 percent. Other parameters including field or armature current, rail bar size, tooth or slot length, frequency, etc., are examined and found to be relatively insensitive. Control options are examined and field weakening, field or current angle control, or armature current control all appear to be feasible alternatives.
A Systematic Review of Alternative Nicotine Delivery System (ANDS)-Based Interventions on Smoking-Related Health Outcomes Among Marginalised Population Groups.

Background: Smoking and smoking-related disease is endemic amongst many marginalised populations such as people experiencing homelessness, people who use drugs, people living with HIV, sex workers and members of the LGBTQ+, Indigenous, Traveller and migrant communities. Alternative Nicotine Delivery Systems (ANDS)-based interventions including those using Nicotine Replacement Therapy (NRT) and Electronic Nicotine Delivery Systems (ENDS) show promise in supporting people to reduce their smoking. However, little is known about ANDS-based smoking reduction interventions with marginalised populations. This systematic review provides a best evidence synthesis of ANDS-based smoking reduction interventions to address this gap.Methods:A systematic review protocol was registered on PROSPERO (CRD42020158832) and literature review conducted through MEDLINE/PubMed, CINAHL, EMBASE, OVID SP, ScienceDirect and Google Scholar. The primary outcomes of cigarette smoking, and biochemical validation of abstinence were reported. Secondary outcomes reported included physical health, mental health and other outcomes.Results: Twenty-Nine studies were included in this review. Thirteen of the included studies were randomised controlled trials (RCTs) (n= 2828) and 16 studies were quasi controlled studies (n=1172). The sample size across the studies ranged from 9 to 775 participants. The mean reported age of participants ranged from 32.4 to 56.9 years old with an overall mean age of 39.55. A minority of study participants identified as female (33.43%; with two studies not reporting gender). A range of ANDS-interventions were found to be effective in reducing smoking amongst a range of marginalised groups. However, the overall quality of both the controlled and quasi experimental studies, as evaluated using the JBI Appraisal Tool, was found to be low.Conclusions: Studies are often evaluated as homogenous interventions although they are frequently a group of interventions and lack power analysis of the effects of individual components of the intervention effect. Several studies suggest potential mental health benefits consequent of ANDS-based intervention, though this effect is poorly explored. There is a current lack of RCTs related to ANDS-based smoking related interventions with people experiencing homelessness. Similarly, there is a lack of properly controlled RCTs exploring the use of ENDS with marginalised populations. Future studies should aim to address these deficits.
Phosphate (Pi) Starvation Up-Regulated GmCSN5A/B Participates in Anthocyanin Synthesis in Soybean (Glycine max) Dependent on Pi Availability

Phosphorus (P) is an essential macronutrient for plant growth and development. Among adaptive strategies of plants to P deficiency, increased anthocyanin accumulation is widely observed in plants, which is tightly regulated by a set of genes at transcription levels. However, it remains unclear whether other key regulators might control anthocyanin synthesis through protein modification under P-deficient conditions. In the study, phosphate (Pi) starvation led to anthocyanin accumulations in soybean (Glycine max) leaves, accompanied with increased transcripts of a group of genes involved in anthocyanin synthesis. Meanwhile, transcripts of GmCSN5A/B, two members of the COP9 signalosome subunit 5 (CSN5) family, were up-regulated in both young and old soybean leaves by Pi starvation. Furthermore, overexpressing GmCSN5A and GmCSN5B in Arabidopsis thaliana significantly resulted in anthocyanin accumulations in shoots, accompanied with increased transcripts of gene functions in anthocyanin synthesis including AtPAL, AtCHS, AtF3H, AtF3′H, AtDFR, AtANS, and AtUF3GT only under P-deficient conditions. Taken together, these results strongly suggest that P deficiency leads to increased anthocyanin synthesis through enhancing expression levels of genes involved in anthocyanin synthesis, which could be regulated by GmCSN5A and GmCSN5B.
Research and Test on User Privilege Elevation Method in Windows 8

Windows 8 is the latest release of Microsoft operating system, the user interface, function and safety have been greatly improved. The user privilege has played a part in operating system security, which can greatly prevent worm programs. The Windows 8 privilege management inherits from Windows Vista’s UAC (User Account Control) system and improved it. Now there are two types of method to elevate user privilege, one is aim at the UAC in Ring 3 mode, the other is attack the kernel of operating system in Ring 0 mode. This paper is primarily analyzing and testing these methods.
Cbln1 regulates axon growth and guidance in multiple neural regions

The accurate construction of neural circuits requires the precise control of axon growth and guidance, which is regulated by multiple growth and guidance cues during early nervous system development. It is generally thought that the growth and guidance cues that control the major steps of axon guidance have been defined. Here, we describe cerebellin-1 (Cbln1) as a novel cue that controls diverse aspects of axon growth and guidance throughout the central nervous system (CNS). Cbln1 has previously been shown to function in late neural development to influence synapse organization. Here we find that Cbln1 has an essential role in early neural development. Cbln1 is expressed on the axons and growth cones of developing commissural neurons and functions in an autocrine manner to promote axon growth. Cbln1 is also expressed in intermediate target tissues and functions as an attractive guidance cue. We find that these functions of Cbln1 are mediated by neurexin-2 (Nrxn2), which functions as the Cbln1 receptor for axon growth and guidance. In addition to the developing spinal cord, we further show that Cbln1 functions in diverse parts of the CNS with major roles in cerebellar parallel fiber growth and retinal ganglion cell axon guidance. Despite the prevailing role of Cbln1 as a synaptic organizer, our study discovers a new and unexpected function for Cbln1 as a general axon growth and guidance cue throughout the nervous system. Impact statement Despite the prevailing role of Cbln1 as a synaptic organizer, our study discovers a new and unexpected function for Cbln1 as a general axon growth and guidance cue throughout the nervous system.