Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit

Assembly of ribosomal subunits into active ribosomal complexes is integral to protein synthesis. Release of eIF6 from the 60S ribosomal subunit primes 60S to associate with the 40S subunit and engage in translation. The dynamics of eIF6 interaction with the uL14 (RPL23) interface of 60S and its regulation by somatic mutations acquired in Shwachman-Diamond Syndrome (SDS) is yet to be clearly understood. Here, by using a modified strategy to obtain high yields of recombinant human eIF6 we have uncovered the critical interface entailing 8 key residues in the C-tail of RPL23 that is essential for physical interactions between 60S and eIF6. Disruption of the complementary binding interface by conformational changes in eIF6 disease variants provide a mechanism for weakened interactions of variants with the 60S. Hydrogen-deuterium exchange mass spectrometry (HDX-MS) analyses uncovered dynamic configurational rearrangements in eIF6 induced by binding to RPL23 and exposed an allosteric interface regulated by the C-tail of eIF6. Disrupting a key residue in the eIF6-60S binding interface markedly limits proliferation of cancer cells, which highlights the significance of therapeutically targeting this interface. Establishing these key interfaces thus provide a therapeutic framework for targeting eIF6 in cancers and SDS.
BRAFV600E Expression in Thyrocytes Causes Recruitment of Immunosuppressive STABILIN-1 Macrophages

Papillary thyroid carcinoma (PTC) is the most frequent histological subtype of thyroid cancers (TC), and BRAFV600E genetic alteration is found in 60% of this endocrine cancer. This oncogene is associated with poor prognosis, resistance to radioiodine therapy and tumor progression. Histological follow-up by anatomo-pathologists reveals that 2/3 of surgically-removed thyroids do not present malignant lesions. Continued fundamental research into the molecular mechanisms of TC downstream of BRAFV600E remains thus central to better understand the clinical behavior of these tumors. To study PTC, we used a mouse model in which expression of BRAFV600E is specifically switched on in thyrocytes by doxycycline administration. Upon daily intraperitoneal doxycycline injection, thyroid tissue rapidly acquired histological features mimicking human PTC. Transcriptomic analysis revealed major changes in immune signaling pathways upon BRAFV600E induction. Multiplex immunofluorescence confirmed the abundant recruitment of macrophages, among which a population of LYVE-1+/CD206+/STABILIN-1+ was dramatically increased. By genetically inactivating the gene coding for the scavenger receptor STABILIN-1, we showed an increase of CD8+ T cells in this in situ BRAFV600E dependent TC. Finally, we demonstrated the presence of CD206+/STABILIN-1+ macrophages in human thyroid pathologies. Altogether, we revealed the recruitment of immunosuppressive STABILIN-1 macrophages a PTC mouse model and the relevance of these observations in human thyroid tissues.
EFFECT OF DIFFERENT LINES OF LOCAL IRAQI CHICKEN AND ISA BROWN ON EGG INTERNAL QUALITY

A total of 500 eggs was obtained from three Iraqi local chickens distributed as feather colors and Isa Brown to determine the internal egg quality and their correlation. Pure Black= group1; Black with Brown Neck= group 2; White= group 3 and Isa Brown = group 4 at 70-80 weeks age old were reared under similar management. Statical analysis of data in this study shows significant (p<0.05) differences in egg weight, yolk weight and shell weight between lines. While, differences between groups in yolk percentage, albumin percentages, shell traits (weight, thickness and percentage) were not significant. The positive correlation coefficients between egg weight were significant (p<0.01) with yolk and albumin weight, and (p<0.05) with shell weight. Also, the correlation between yolk weight and shell weight was significantly (p<0.01) positive, while the correlation between albumin weight with shell weight was negatively non significant. The positive correlation was observed between egg weight with yolk and shell percentages, while, the correlation between yolk with albumin percentages, and albumin percentages with shell percentages were negatively significant (p<0.01). The results from this study indicated that the different groups of local chickens and Isa brown significantly affected egg weight and some internal egg traits.
Digital Voltage Sampling Scheme for Primary-Side Regulation Flyback Converter in CCM and DCM Modes

Primary-side regulation (PSR) flyback topology with discontinuous conduction modulation (DCM) mode has been widely used in low-power application due to its high stability, wide input voltage range, low cost, and low standby power. To improve the output power, continuous conduction modulation (CCM) mode is always introduced. However, in CCM mode, conventional PSR voltage-sampling method cannot realize high precision of output voltage or the voltage sampling method requires complex control of high cost. In this paper, a simple digital voltage sampling scheme with two reference voltages outputted from a digital-to-analog converter (DAC) is put forward to trace the “accurate-point” voltage for DCM and CCM modes. In CCM mode, the sampling voltage error of the “knee-point” voltage can be compensated just by inserting DCM switching cycle to obtain the “accurate-point” voltage. Voltage difference between DCM mode and CCM mode will be eliminated, and high precision is easily realized. The proposed method is verified in a 20V, 65W PSR flyback converter. The sampling method only requires a low speed DAC, three comparators and a digital controller. The output voltage precision is within 0.6% with universal input voltage.
Spatial Structure-Aware Road Network Embedding via Graph Contrastive Learning

Road networks are widely used as a fundamental structure in urban transportation studies. In recent years, with more research leveraging deep learning to solve conventional transportation problems, how to obtain robust road network representations (i.e., embeddings) applicable for a wide range of applications became a fundamental need. Existing studies mainly adopt graph embedding methods. Such methods, however, foremost learn the topological correlations of road networks but ignore the spatial structure (i.e., spatial correlations) which are also important in applications such as querying similar trajectories. Besides, most studies learn task-speci � c embeddings in a supervised manner such that the embeddings are sub-optimal when being used for new tasks. It is ine � cient to store or learn dedicated embeddings for every di � erent task in a large transportation system. To tackle these issues, we propose a model named SARN to learn generic and task-agnostic road network embeddings based on self-supervised contrastive learning. We present (i) a spatial similarity matrix to help learn the spatial correlations of the roads, (ii) a sampling strategy based on the spatial structure of a road network to form self-supervised training samples, and (iii) a two-level loss function to guide SARN to learn embeddings based on both local and global contrasts of similar and dissimilar road segments. Experimental results on three downstream tasks over real-world road networks show that SARN outperforms state-of-the-art self-supervised models consistently and achieves comparable (or even better) performance to supervised models.
Are Bilateral Remittances Countercyclical? The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters

By putting together a relatively large data set on bilateral remittances of emigrants, this paper is able to shed light on the important hypothesis of smoothing. The smoothing hypothesis is that remittances are countercyclical with respect to income in the worker‟s country of origin (the recipient of the remittance), while procyclical with respect to income in the migrant‟s host country (the sender of the remittance). The econometric results confirm the hypothesis. This affirmation of smoothing is important for two reasons. First, it suggests that remittances should be placed on the list of criteria for an optimum currency area. Second, it brings into doubt plans by governments in some developing countries to harness remittances for their own use, in that government spending in these countries generally fails the test of countercyclicality which remittances pass.
Spectral Line Advanced Topics

This chapter is in three parts. The ﬁrst gives the fundamental equations of level populations and radiative transfer which govern spectral line emission and absorption. Lines in the cm-wave band have similari-ties which allow us to simplify the equations. The further simpliﬁcation of a two level system (a good approximation for H I ) gives the familiar formulae for the 21-cm line. The second part of the lesson deals with mapping, and the combination of single dish and interferometer data. We consider the eﬀect of gridding single dish data using a convolving function. Mapping speeds and techniques are discussed. The third part discusses the spectral line cube and its moments. The use of the ﬁrst moments to determine the dynamical structure of a disk is discussed. The need for windowing in the cube before computing moments is justiﬁed.
ROMANIAN PREMIUM HONEY CONSUMER’S PERCEPTIONS ABOUT TRACEABILITY

Romania is the fourth biggest producer of honey in Europe. The increasing attention paid to traceability in Europe raised our interest in developing this study. The main objectives were to determine the profile of honey consumers of a particular Romanian premium brand, their perceptions regarding quality and traceability and their willingness to pay for traceability. The research was conducted using a quantitative method based on the use of online questionnaire. As the number of initial statistic population was not known, the sample size was empirical and non-probabilistic. There were filled up in total 85 questionnaires. The analysis of data was carried out using a database created in SPSS. The results of the study showed customers consider necessary traceability so as to ensure safety of the food products and their quality. They would identify a traced honey with the aid of the information on the label. Approximately 80% of respondents are ready to pay an extra bid for honey with a traceability system. To conclude, this study confirms that traceability should not be seen by producers only as regulatory benefit but also as competitive advantage and tool for valorizing their products.
Simulating Multi-Agent Systems Using Deep Reinforcement Learning

—Reinforcement Learning has been getting a lot of attention in recent years, mostly due to its use in teaching computers to play video and board games. In this report we investigate how well algorithms from this area can be used to solve a multi-agent problem. The multi-agent problem to be solved is teaching robots how to transport items in a warehouse without colliding. First, we propose a Q-learning based algorithm. However, the performance of Q-learning scales poorly as the complexity of the system increases. The system’s complexity is characterized by the number of agents and the size of the environment. Due to these scalability issues, we also propose an algorithm based on Deep Q-Networks (DQN). Simulations are made to illustrate the behavior of the proposed algorithms. The results of the simulations suggest that DQN converges quicker compared to Q-learning for systems of higher complexity.
Starch granules from human teeth: New clues on the Epi-Jomon diet

This study examined starch granules from the dental calculus of specimens from the Epi-Jomon (Zoku-Jomon in Japanese, ca. 350 BCE–350 CE) period in Japan for taxonomic identification of plant food items and the reconstruction of human socioeconomic practices. Dental calculus was extracted from 21 individuals across six Epi-Jomon sites in Hokkaido. Moreover, 12 starch granules and starch clusters were recovered from nine individuals. The morphologies of the extracted starch granules were then classified into five types: elliptical, angular circular, polygonal, pentagonal, and damaged. Morphometric analysis indicated that a small portion of these starch granules may have derived from acorns, nuts, and bulb or tuber plants, with one starch granule supposedly from rice. Although extracted starch granules are poor predictors of food diversity at the individual level, the results can identify potential food sources of the surveyed population. This is the first study to determine how well plant microremains in dental calculus reflect a plant diet in the Epi-Jomon population. The starch granules discovered at the surveyed sites provide essential information about the utilization of plant species and cultural contacts in Hokkaido during this period. This is of great significance in reconstructing the Epi-Jomon subsistence patterns in Hokkaido and exploring cultural interactions between hunting-gathering-fishing and agrarian societies.
Metonymic event-based time interval concepts in Mandarin Chinese—Evidence from time interval words

Starting from the overwhelming view that time is metaphorically conceptualized in terms of space, this study will, on the one hand, take the time interval words into minute analysis to confirm our view of event conceptualization of time at a more basic level along with space–time metaphoric conceptualization of time at a relational level. In alignment with the epistemology of the time–space conflation of the Chinese ancestors, our view is supported by the systematic examination of evidence related to the cultural origins of the conceptualization of time, through a scrutiny of the original meanings and construction of words related to intervals of time in Mandarin Chinese. This study offers a new explanation of how: (1) the conceptualization of time in Chinese is realized through metonymic cognition and (2) words related to specific intervals of time are coined based on the metonymic conceptualization of related events or a corresponding event schema. Five major types of event-based metonymies are identified, and their interactive functions are illustrated. Based on this evidence, we argue that the double nature of both metaphoric and metonymic time conceptualization in Mandarin Chinese lies in the fact that time interval words can be used in its time categorial sense or as a time entity which suggests the etymological origins of Chinese as ideograph. It is concluded therefore that the event-based metonymy conceptualization of time can provide better insights into the characteristics of Chinese modes of thinking and its influences on the perception of and interaction with the world. This study can also serve as good evidence for the shaping effect of language on cognition.
The influence on fish and seafood consumption, and the attitudes and reasons for its consumption in the Croatian population

Fish makes an important part of the Mediterranean diet, which has been scientifically proven to help preserve human health by protecting against major chronic and inflammatory diseases. Eating fish and seafood is very important, not only for its proven health benefits but also for its positive impact on the environment. Due to many fish and seafood significant positive effects on human health, this study aimed to investigate the socio-demographic factors associated with the consumption of fish and seafood in the population of Primorsko-goranska County in Croatia. Another aim was to determine people's attitudes, choices, and reasons for the consumption of fish and seafood. Self-reported data from 2,910 participants were used. According to the European dietary recommendations for fish consumption, the participants were divided into two groups; the very low to low fish consumption group and the moderate to high fish consumption group, in order to examine the differences in socio-demographic and lifestyle variables, and their attitudes, opinions, and reasons for fish and seafood consumption. More fish and seafood were consumed by women, the elderly, the more educated, non-smokers, and more physically active participants. Age, the highest level of education, and a diet even moderately adherent to the Mediterranean diet was found to significantly increase the likelihood of recommended fish consumption. Participants considered the best reasons to consume more fish lower prices, buy much more locally produced fishery products, and prefer to eat wild-caught fish rather than farmed fish. The study has found a slight increase in fish consumption, although still lower than the European average. It also showed significant socio-demographic associations, also the reasons and attitudes toward higher fish and seafood consumption of the Croatian population. The obtained research data are valuable for planning future public health programs in Croatia aimed at greater consumption of fish and seafood, as well as their promotion as an important part of a sustainable diet.
Responding to stakeholder needs to engage rehabilitation professionals in the delivery of evidence-based health programming for adults with osteoarthritis

Although there are many evidence-based programs that promote healthy lifestyles and symptom modification for people with osteoarthritis, their delivery in rehabilitation clinical settings in the United States is limited. These programs can be a primary component of treatment or a discharge option to facilitate long-term mobility and pain management. The purpose of this perspective article is to describe a delivery model that brings one arthritis-appropriate, evidence-based intervention, the Arthritis Foundation's Walk With Ease program, to older adults seeking physical therapy related to their osteoarthritis. We embedded program delivery into a Doctor of Physical Therapy curriculum using a student health coaching approach and partnering with physical therapy clinics and other community agencies for participant referrals. This model of delivery is cost-effective, sustainable, and provides outcomes that meet goals of the national agenda for osteoarthritis. The model provides benefits for students in health professions education programs, community organizations and rehabilitation clinics, and adults living with osteoarthritis.
Complex metabolic interactions between ovary, plasma, urine, and hair in ovarian cancer

Ovarian cancer (OC) is the third most common malignant tumor of women accompanied by alteration of systemic metabolism, yet the underlying interactions between the local OC tissue and other system biofluids remain unclear. In this study, we recruited 17 OC patients, 16 benign ovarian tumor (BOT) patients, and 14 control patients to collect biological samples including ovary plasma, urine, and hair from the same patient. The metabolic features of samples were characterized using a global and targeted metabolic profiling strategy based on Gas chromatography-mass spectrometry (GC-MS). Principal component analysis (PCA) revealed that the metabolites display obvious differences in ovary tissue, plasma, and urine between OC and non-malignant groups but not in hair samples. The metabolic alterations in OC tissue included elevated glycolysis (lactic acid) and TCA cycle intermediates (malic acid, fumaric acid) were related to energy metabolism. Furthermore, the increased levels of glutathione and polyunsaturated fatty acids (linoleic acid) together with decreased levels of saturated fatty acid (palmitic acid) were observed, which might be associated with the anti-oxidative stress capability of cancer. Furthermore, how metabolite profile changes across differential biospecimens were compared in OC patients. Plasma and urine showed a lower concentration of amino acids (alanine, aspartic acid, glutamic acid, proline, leucine, and cysteine) than the malignant ovary. Plasma exhibited the highest concentrations of fatty acids (stearic acid, EPA, and arachidonic acid), while TCA cycle intermediates (succinic acid, citric acid, and malic acid) were most concentrated in the urine. In addition, five plasma metabolites and three urine metabolites showed the best specificity and sensitivity in differentiating the OC group from the control or BOT groups (AUC > 0.90) using machine learning modeling. Overall, this study provided further insight into different specimen metabolic characteristics between OC and non-malignant disease and identified the metabolic fluctuation across ovary and biofluids.
Death cafés as a strategy to foster compassionate communities: Contributions for death and grief literacy

COPYRIGHT © 2022 Laranjeira, Dixe, Querido and Stritch. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Death cafés as a strategy to foster compassionate communities: Contributions for death and grief literacy
Pathology confirmation of the efficacy and safety of microwave ablation in papillary thyroid carcinoma

Background The incidence of papillary thyroid carcinoma (PTC) has rapidly increased in recent years. Microwave ablation (MWA) was proposed as an alternative treatment for PTC. This study aimed to investigate the efficacy and safety of MWA by exploring the postoperative pathology results of post-ablation lesions in patients with PTC. Methods This study retrospectively analyzed data from 12 patients who underwent thyroid surgery after MWA treatment for primary PTC between January 2015 and November 2021 in six hospitals. Results The average age of the 12 patients (8 female) was 45.3 ± 9.7 years. There was one patient with PTC (size > 1 cm) and 11 patients with micro-PTC (size ≤ 1 cm), of which eight patients had unifocal micro-PTC and three patients had multifocal micro-PTC. A total of 17 tumor foci with mean size of 6.2 ± 2.6 mm were treated by MWA. The median interval time between MWA and surgery was 6.6 months (range: 0.4–21.9 months). Intraoperatively, adherence to the anterior cervical muscle group was observed in three cases (3/12). Upon postoperative pathologic examination, all the post-ablation lesions of the eight unifocal micro-PTC and two multifocal micro-PTC showed no residual carcinomas. Outside the ablation zone, PTCs were detected in three cases, including two of the eight patients with unifocal micro-PTC and one of the three patients with multifocal micro-PTC. Cervical lymph node metastases were detected in seven patients (7/12). Conclusion MWA was feasible for the treatment of primary unifocal low-risk micro-PTC (T1aN0M0) with good efficacy and safety. However, the use of MWA for treating PTC (size > 1 cm) and multifocal micro-PTC remains controversial.
Editorial: Proteases of the prokaryotic cell envelope

COPYRIGHT © 2022 De Castro and Poetsch. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Editorial: Proteases of the prokaryotic cell envelope