Miracle-dz/UniFAR-FTUs huggingface dataset:
Targeting crosstalk of STAT3 between tumor-associated M2 macrophages and Tregs in colorectal cancer

ABSTRACT A comprehensive analysis of the molecular mechanism underlying colorectal tumor evaluated the development of colorectal cancer (CRC) and proposed targeting small molecular inhibitors. Nonetheless, the adoptive resistance of these therapies remains a challenge with respect to achieving an effective clinical response. Thus, identifying the molecular mechanisms guiding CRC growth is essential. The results of The Cancer Genome Atlas (TCGA) dataset analysis demonstrated a critical role of signal transducer and activator of transcription 3 (STAT3) pathway in tumor immune suppression via modulation of the recruitment of Treg cells and M2 type tumor-associated macrophages. The in vivo experiments elucidate that targeting STAT3 pathways markedly reduce the proportions of TAMs and Tregs by inhibiting tumor progression. These findings revealed crosstalk between Treg cells and M2 macrophages, proving a potential therapeutic strategy for CRC therapy. Combinatorial treatment with STAT3 inhibitor and programmed death 1 (PD-1) antibody therapy effectively prevents CRC tumor growth in a mouse model with high anti-tumor immunity. In summary, targeting STAT3 disrupts the interaction between Treg cells and M2 macrophages and improves the anti-tumor response in CRC, thereby offering a promising strategy to treat patients with CRC.
Behind closed doors: Protective social behavior during the COVID-19 pandemic

The success of personal non-pharmaceutical interventions as a public health strategy requires a high level of compliance from individuals in private social settings. Strategies to increase compliance in these hard-to-reach settings depend upon a comprehensive understanding of the patterns and predictors of protective social behavior. Social cognitive models of protective behavior emphasize the contribution of individual-level factors while social-ecological models emphasize the contribution of environmental factors. This study draws on 28 waves of survey data from the Understanding Coronavirus in America survey to measure patterns of adherence to two protective social behaviors–private social-distancing behavior and private masking behavior–during the COVID-19 pandemic and to assess the role individual and environmental factors play in predicting adherence. Results show that patterns of adherence fall into three categories marked by high, moderate, and low levels of adherence, with just under half of respondents exhibiting a high level of adherence. Health beliefs emerge as the single strongest predictor of adherence. All other environmental and individual-level predictors have relatively poor predictive power or primarily indirect effects.
Simulated Annealing Algorithm for B´ ezier Curve Approximation

Curve approximation is a very important topic in many industrial and applied fields. The typical input in real- world applications is a set of sampled data points for which a fitting curve is to be obtained. This paper addresses this problem by using Bcurves as the approximating functions. This formulation leads to a continuous multivariate nonlinear optimization problem. Unfortunately, this is very difficult prob- lem that cannot be solved with classical mathematical optimiza- tion techniques. In this paper, we solve the problem through a hybrid strategy combining classical methods (linear least- squares minimization), modern stochastic methods (simulated annealing) and information science metrics. For a given degree n, our method computes a near-to-optimal parameterization of data points by using simulated annealing for global search and a local search optimizer for further refinement of the global solution. Then, we compute the control points by least- squares minimization. Finally, we determine the best value for the degree of the curve by using two information science metrics that represent an adequate compromise between data- fidelity and model-complexity. Our method is applied to four illustrative examples of mathematical curves and noisy scanned data and different configurations. Our experimental results show that the method performs well for all examples. Keywords-B´ ezier; reverse-engineering; simulated annealing.
Two tigers cannot live on the same mountain: The impact of the second largest shareholder on controlling shareholder’s tunneling behavior

Under the current corporate governance model, the second largest shareholder (SLS) is a very special, common and important presence, which becomes an important counterweight to the controlling shareholder (CS). Through a game matrix, this paper explains whether the SLS will supervise the CS’s tunneling behavior. Based on this, we empirically examine the effect of the SLS on CS’s tunneling behavior in Chinese listed firms between 2010 and 2020. The results indicate that the SLS significantly inhibits CS’s tunneling behavior. In addition, the heterogeneity analysis reveals that the negative effect of the SLS on CS’s tunneling behavior is concentrated in non-state-owned enterprises (NSOEs) and enterprises located in regions with better business environment. This paper provides a reference for resolving the current "conflict of interest" among multiple large shareholders (MLSs), as well as evidence to support the governance role of the SLS in listed firms with MLSs.
Tight extensions of normed spaces

In this note we show that bound extensions as defined by Kaufman (Acta Univ. (Szeged) 21 (1966), 163) and tight extensions as defined by Dress (Adv. in Math. 53 (1984), 322) are the same. Further we find that the property of being a bound extension is preserved under complexification.
Borderline Personality Organization as an Aid in Differential Diagnosis

Abstract There are subsets of patients whose presentations elude a precise diagnosis. All diagnoses are asymptotic to nature as they are constructs imposed on the world. Nonetheless, a greater degree of accuracy and precision is possible and beneficial for most patients. This is particularly true for patients with borderline personality organization (BPO) who present with psychotic symptoms. For the purposes of avoiding a misconstrual of the meaning of psychotic experiences in these patients, a brief synopsis of borderline personality organization, in contradistinction to borderline personality disorder, may prove to be of some clinical utility. The BPO construct presciently anticipates the trend toward a dimensional model of personality disorders and has the potential to enrich and inform these developments.
High purity and integrity RNA from human cell lines stored in liquid nitrogen for over 20 years

Biobanks are a key resource for obtaining human cell lines for biomedical research, including for drug development projects. Such projects often include comparative RNA‐sequencing of large panels of human cell lines from individuals affected by certain disorders and healthy controls, or from individuals with different drug response phenotypes. RNA extractions are typically done from growing cell cultures, a process that may take several weeks. However, maintaining large numbers of cell lines in parallel increases the project workload. Here, we show that extracting RNAs directly from frozen vials of human cell lines stored for over 20 years in a liquid nitrogen freezer yields RNAs with the high purity and integrity parameters that conform to those required for optimal RNA‐sequencing and are closely similar to those obtained for RNAs extracted from growing human cell lines.
Method for estimation of the delivery of sediments and solutes from Greenland to the ocean

Greenland is the largest island in the world, with an area 2 415 100 km" and a smoothed coastline length of 7500 km, bordering the Atlantic Ocean, the Arctic Ocean and the sea between west Greenland and Canada. Very few gauging stations at which discharge is measured are located in this huge area, and the dissolved and sediment load are monitored at even fewer stations. Estimating the supply of sediment and solutes to the surround­ ing seas is therefore in reality a case of estimating loads from an ungauged area. This presentation discusses methods for estimation, and presents prelim­ inary estimates of loads. BACKGROUND AND SCOPE Greenland stretches from 60 to 84°N, with an area of 2 415 100 km2, of which 75% is covered by the Greenland Ice Sheet. Around the Greenland Ice Sheet, a narrow band of land is found with a width that reaches up to approximately 200 km. In several places, ice lobes from the Greenland Ice Sheet reach the open sea directly, whereas in other places the ice lobes emerge in the inner parts of fiords with longer distances to the open sea. Several local glaciers are located in this band of land, which in some places discharge directly into the sea and in others discharge into fiords or shallow coastal waters. The part of the land not covered by glaciers drains into the sea through rivers. Due to its northern location and the presence of the Greenland Ice Sheet, Greenland suffers from an arctic to high arctic climate. The annual average tempera­ ture is 2°C at Narsarsuaq (in the south) and -17°C at Station Nord (in the north). The annual temperature amplitude varies between 15 and 33°C. The annual precipitation varies from 1000 to 3000 mm along the south and southeast coast, down to 100-200 mm in the northern part. Most of the precipitation falls as snow. As a consequence of the climate, strong mechanical weathering takes place, together with periglacial processes and glacial erosion. The river regime is glacio-nival, with a flood period during the spring.
Impact of a bi-annual community-directed treatment with ivermectin programme on the incidence of epilepsy in an onchocerciasis-endemic area of Mahenge, Tanzania: A population-based prospective study

Background Community-directed treatment with ivermectin (CDTi) is used to eliminate onchocerciasis. However, despite 25 years of annual CDTi in Mahenge, Tanzania, the prevalence of onchocerciasis and onchocerciasis-associated epilepsy remained high in certain rural villages. Therefore, in 2019, bi-annual CDTi was introduced in the area. This study assessed the impact of the programme on the incidence of epilepsy in four villages. Methodology Door-to-door epilepsy surveys were conducted prior to (2017/18) and after (2021) implementing a bi-annual CDTi program. All household members were screened for epilepsy symptoms using a validated questionnaire, and suspected cases were examined by a medical doctor to confirm/reject the diagnosis of epilepsy. The prevalence and annual incidence of epilepsy, including nodding syndrome, were calculated with 95% Wilson confidence intervals with continuity correction. The latter was also done for CDTi coverage in 2016 and 2021. Results Precisely 5,444 and 6,598 persons were screened for epilepsy before and after implementing the intervention. The CDTi coverage of the overall population was 82.3% (95%CI: 81.3–83.2%) in 2021 and sustained in both distribution rounds (81.5% and 76.8%). The coverage was particularly high in children and teenagers aged 6 to 18 years (93.2%, 95%CI: 92.1–94.2%). The epilepsy prevalence remained similar: 3.3% (95%CI: 2.9–3.9%) in 2017/18 versus 3.1% (95%CI: 2.7–3.5%) in 2021. However, the incidence of epilepsy declined from 177.6 (95%CI: 121.2–258.5) in 2015–2017 and 2016–2018 to 45.5 (95%CI: 22.2–89.7) in 2019–2021 per 100,000 persons-years. The incidence of probable nodding syndrome varied from 18.4 (95%CI: 4.7–58.5) to 5.1 (95%CI: 0.3–32.8). None of the nine incidence cases of epilepsy for which information on ivermectin intake was available took ivermectin in the year they developed their first seizures. Conclusion A bi-annual CDTi programme should be implemented in areas with high prevalence of onchocerciasis and epilepsy. High CDTi coverage among children is particularly important to prevent onchocerciasis-associated epilepsy.
Conservation and Diversification of Pallial Cell Types across Vertebrates: An Evo-Devo Perspective

As the highest center of sensory processing, initiation, and modulation of behavior, the pallium has seen prominent changes during the course of vertebrate evolution, culminating in the emergence of the mammalian isocortex. The processes underlying this remarkable evolution have been a matter of debate for several centuries. Recent studies using modern techniques in a host of vertebrate species are beginning to reveal mechanistic principles underlying pallial evolution from the developmental, connectome, transcriptome and cell type levels. We attempt here to trace and reconstruct the evolution of pallium from an evo-devo perspective, focusing on two phylogenetic extremes in vertebrates – cyclostomes and mammals, while considering data from intercalated species. We conclude that two fundamental processes of evolutionary change – conservation and diversification of cell types, driven by functional demands, are the primary forces dictating the emergence of the diversity of pallial structures and imbibing them with the ability to mediate and control the exceptional variety of motor behaviors across vertebrates.
Materials and device concepts for electrocaloric refrigeration

Electrocaloric (EC) materials provide a solid-state cooling technology without polluting liquid refrigerants and noisy mechanical parts. Currently, basic research in this field is mainly focused on materials with a first-order phase transition exhibiting a large polarization change in a narrow temperature region near the phase transition point (Curie temperature) and, thus, a large EC effect. In this contribution, device operation above Curie temperature will be discussed. In this case, the polarization change originates from the temperature coefficient of the dielectric permittivity. To optimize material properties for EC refrigerator applications, we adapt the modified Curie–Weiss law describing a large class of ferroelectrics with a diffuse phase transition. Device performance will be evaluated based on the expected cooling power in dependence on thermodynamic cycle time, total thermal resistance and EC material thickness.
More Jets in more LHC searches

Multi jet observables are a powerful tool to new physics as well as a boost to standard analysis strategies. We show their use in a reasonably model independent dark matter search and a jet veto Higgs analysis. We find however that, these observables are plagued by huge theoretical uncertainties connected to unphysical scale parameters. In the democratic limit we compute analytically the all order resummed jet spectrum at leading log. It obeys so called staircase scaling. With the help of state of the art Monte Carlo tools we study the jet spectrum features in great detail. In addition we also study so called Poisson scaling. This allows us to develop a data driven strategy to fix the standard model multi jet backgrounds.
Screening for antimicrobial residues in poultry eggs in Bangladesh using Charm II radio-receptor assay technique following validation

ABSTRACT The aim of the study was to screen for the presence of antimicrobial residues in poultry eggs from Bangladesh using the Charm II radio-receptor assay in the absence of expensive confirmatory instrumentation. This was based on cut-off values as set in the validation guidelines according to Commission Decision 2002/657/EC and Commission Implementing Regulation (EU) 2021/808. Fortified eggs spiked with fixed concentrations of doxycycline, erythromycin A, sulphamethazine, and benzylpenicillin were used to determine the cut-off values and detection capabilities (CCβ). Other validation parameters included were applicability, ruggedness, and robustness. A total of 201 egg mix samples from native organic chicken, duck, and commercial farm-raised laying hens (both brown and white eggs) were tested and after analysis 13%, 10%, and 4.5% of the egg mix samples showed positive signals for sulphonamides, macrolides/lincosamides, and tetracyclines, respectively. Presence of multiple drug residues were also suspected in 11 out of 201 egg mix samples.
A practical interconnection network RP（k） and its routing algorithms

Based on Petersen graph, a new interconnection network, the RP(k) network, is developed and the properties of the RP(k) network are investigated. The diameter of the RP(k) network is [ k/2] + 2 and its degree is 5. We prove that the diameter of the RP(k) network is much smaller than that of the 2-D Torus network when the number of nodes in interconnection networks is less than or equal to 300. In order to analyze the communication performance in a group of nodes, we propose the concepts of the optimal node groups and the diameter of the optimal node groups. We also show that the diameter of the optimal node groups in the RP(k) network is less than that in the 2-D Torus network. Especially when the number of nodes in an optimal node group is between 6 and 100, the diameter of the optimal node groups in the RP(k) network is half of that in the 2-D Torus network. Furthermore based on the RP(k) network we design a set of routing algorithms which are point-to-point routing, permutation routing, one-to-all routing and all-to-all routing. Their communication efficiencies are [k/2] + 2, k + 5, [k/2] + 2, and k + 5 respectively. The RP(k) network and the routing algorithms can provide efficient communication means for parallel and distributed computer system.
Dynamic Balance During Walking in Transfemoral Prosthesis Users: Step-to-Step Changes in Whole-Body and Segment Angular Momenta

Transfemoral prosthesis users (TFPUs) typically have a high risk of balance loss and falling. Whole-body angular momentum (<inline-formula> <tex-math notation="LaTeX">${\overrightarrow {H}}_{{\text {WB}}}{)}$ </tex-math></inline-formula> is a common measure for assessing dynamic balance during human walking. However, little is known about how unilateral TFPUs maintain this dynamic balance through segment-to-segment cancellation strategies. Better understanding of the underlying mechanisms of dynamic balance control in TFPUs is required to improve gait safety. Thus, this study aimed to evaluate dynamic balance in unilateral TFPUs during walking at a self-selected constant speed. Fourteen unilateral TFPUs and fourteen matched controls performed level-ground walking at a comfortable speed on a straight, 10-m-long walkway. In the sagittal plane, the TFPUs had a greater and smaller range of <inline-formula> <tex-math notation="LaTeX">$\overrightarrow {H}_{{\text {WB}}}$ </tex-math></inline-formula> compared to controls during intact and prosthetic steps, respectively. Further, the TFPUs generated greater average positive and negative <inline-formula> <tex-math notation="LaTeX">$\overrightarrow {H}_{{\text {WB}}}$ </tex-math></inline-formula> than did the controls during intact and prosthetic steps, respectively, which may necessitate larger step-to-step postural changes in the forward and backward rotation about the body center of mass (COM). In the transverse plane, no significant difference was observed in the range of <inline-formula> <tex-math notation="LaTeX">$\overrightarrow {H}_{{\text {WB}}}$ </tex-math></inline-formula> between groups. However, the TFPUs displayed smaller negative average <inline-formula> <tex-math notation="LaTeX">$\overrightarrow {H}_{{\text {WB}}}$ </tex-math></inline-formula> in the transverse plane than did the controls. In the frontal plane, the TFPUs and controls demonstrated similar range of <inline-formula> <tex-math notation="LaTeX">$\overrightarrow {H}_{{\text {WB}}}$ </tex-math></inline-formula> and step-to-step whole-body dynamic balance owing to the employment of different segment-to-segment cancellation strategies. Our findings should be interpreted and generalized with caution for the demographic features in our participants.
A robust SUPG norm a posteriori error estimator for the SUPG finite element approximation of stationary convection-diffusion equations

A robust residual-based a posteriori estimator is proposed for the SUPG finite element method applied to stationary convection-diffusion-reaction equations. The error in the natural SUPG norm is estimated. The main concern of this paper is the consideration of the convection-dominated regime. A global upper bound and a local lower bound for the error are derived, where the global upper estimate relies on some hypotheses. Numerical studies demonstrate the robustness of the estimator and the fulfillment of the hypotheses. A comparison to other residual-based estimators with respect to the adaptive grid refinement is also provided.
Anti-neurofascin 155 Antibody-positive Neuropathy in a Human Immunodeficiency Virus-infected Patient

Human immunodeficiency virus (HIV)-associated neuropathy is a common complication of HIV infection and has several clinical subtypes. HIV-associated chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a demyelinating neuropathy whose clinical features are known to differ from those of CIDP in the HIV-uninfected population. We herein report a case of CIDP in an HIV-infected patient who was finally diagnosed with anti-neurofascin 155 (NF155) antibody-positive neuropathy. The clinical features, including clinical findings and therapeutic responses, were typical of paranodal antibody-mediated neuropathy. To our knowledge, this is the first case of anti-NF155 antibody-associated neuropathy in an HIV-infected patient.
An Indicial-Polhamus Aerodynamic Model OfInsect-like Flapping Wings In Hover

As part of the ongoing development of flapping-wing micro air vehicle prototypes at Cranfield University (Defence Academy Shrivenham), a model of insect-like wing aerodynamics in hover has been developed and implemented as MATLAB code. The model is intended to give better insight into the various aerodynamic effects on the wing, and therefore is as close to being purely analytical as possible. The model is modular, with the various effects treated separately. This modularity aids analysis and insight, and allows refinement of individual parts. However, it comes at the expense of considerable simplification, which requires empirical verification. The model starts from quasi-steady inviscid flow around a thin 2D rigid flat wing section, accounting for viscosity with the Kutta–Joukowski condition, and the leading edge suction analogy of Polhamus. Wake effects are modelled using the models of Kussner and Wagner, on a prescribed wake shape, as initially used by Loewy. The model has been validated against experimental data from Dickinson’s Robofly and found to give acceptable accuracy. Some empirically inspired refinements of the Polhamus effect are outlined, but these need further empirical validation.
A novel method for sensing metastatic cells in the CSF of pediatric population with medulloblastoma by frequency domain FLIM system

Brain tumors are the second leading cause of cancer-related deaths in children, after leukemia. Patients with cancer in the central nervous system have a very low recovery rate. Today known imaging and cytology techniques are not always sensitive enough for an early detection of both tumor and its metastatic spread, moreover the detection is generally limited, reviewer dependent and takes a relatively long time. Medulloblastoma (MB) is the most common malignant brain tumor in children. The aim of our talk is to present the frequency domain fluorescence lifetime imaging microscopy system as a possible method for an early detection of MB and its metastatic spread in the cerebrospinal fluids within the pediatric population.