Miracle-dz/UniFAR-FTUs huggingface dataset:
Kobe University Repository : Kernel タイトル Tit le Characterist ics of coronary artery disease in chronic kidney disease 著者

Patients with chronic kidney disease (CKD) commonly experience cardiovascular disease (CVD), and a major cause of death in these patients is CVD. Therefore, the prevention of CVD progression is very crucial in patients with CKD. Recently, this relationship between CKD and CVD has increasingly been examined, and a concept termed “cardiorenal syndrome” has been advocated. Coronary artery disease (CAD) and myocardial injury are crucial factors that contribute to the occurrence of CVD. The initial step CAD is endothelial dysfunction that can be detected as a decrease in the coronary flow reserve (CFR). The previous studies have reported that decreased CFR is significantly correlated to coronary events and mortality. Furthermore, CFR reduces with a decline in the kidney function. Another important presentation of CAD is coronary artery calcification. Vascular calcification is a crucial pathophysiological state, particularly in patients with CKD, and it affects the stability of coronary atherosclerotic plaque. In CKD, not only the traditional risk factors but also CKD-related nontraditional risk factors play key roles in CVD progression. Therefore, the mechanisms responsible for CVD progression are very complex; however, their clarification is crucial to improve the prognosis in patients with CKD.
CMAR_A_303122 3685..3697

1South China University of Technology School of Medicine, Guangzhou Higher Education Mega Center, Guangzhou, 510006, Guangdong, People’s Republic of China; 2Department of Oncology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510407, People’s Republic of China; 3Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, People’s Republic of China Aim: Basal epithelial cells are absent in distant prostate cancer. This study aimed to investigate whether basal epithelial cells could suppress migration and invasion of prostate cancer cells to become a new treatment strategy for prostate cancer. Main Methods: Basal epithelial cells were identified by immunofluorescence with anti-p63. Wound healing assays or transwell assays were used to explore the effects of basal epithelial cells, TGF-β1, SB431542 (inhibitor of TGF-β type I receptor) or stattic (inhibitor of phosphorylated STAT3) on migration or invasion of mouse prostate cancer cell (RM-1). Concentration of TGF-β1 was measured by ELISA assay. HE staining was used to investigate cell morphology. Immunocytochemistry with anti-p63 was used to identify basal epithelial cells. Levels of STAT3, p-STAT3 (Ser727) and proteins associated with EMT were measured with Western blot assay. Cell proliferation was measured with MTT or CCK8 assay. Results: Normal basal epithelial cells acquired from mouse prostate were specific to antip63 and more than 90%. Basal epithelial cells and RM-1 could both secrete TGF-β1. Basal epithelial cells and TGF-β1 promoted the migration and invasion of RM-1 through changing the cell morphology and up-regulating expression of ZEB1, N-cadherin, vimentin, snail and p-STAT3 (Ser727), at the same time down-regulating E-cadherin of RM-1. SB431542 strongly suppressed migration, invasion as well as the expressions of EMT relevant proteins and p-STAT3 (Ser727) of co-cultured RM-1. In addition, stattic suppressed proliferation, migration and invasion of non-treated RM-1 and co-cultured RM-1. Conclusion: Our study suggests that normal basal epithelial cells might stimulate the migration and invasion of RM-1 by TGF-β1/STAT3 axis which could be suppressed by inhibitor of TGF-β receptor and inhibitor of p-STAT3. So, basal epithelial cells might not become a treatment strategy for prostate cancer, but our results could provide some researching references for other diseases which include basal epithelial cells such as prostatic intraepithelial neoplasia, prostatic hyperplasia, cervical cancer, or urinary bladder cancer.
A Safe Traffic Network Design and Architecture, in the Context of IoT

— Today’s life has been simplified by the advent of IoT technology. Smart Homes and Smart Cities tend to be the most frequent subject of study, on this field of science. This work is concentrated on the design and implementation of an IoT network, over smart roads. Car accidents’ rate gets higher over the years. A smart road network might offer very useful data for the construction of a real-time accident and traffic preventer. Hardware implementations are also included. The architecture, security and privacy preservation of the network are highlighted. Cryptography could be the tool to the creation of a safe and useful IoT application. A concluding solution to the Road Tragedy phenomenon may be offered by the Academic study and research. Safe and effective smart networks’ research and development may simplify daily life and eliminate fundamental issues. All these solutions may be applied to the human society, as very useful and trustworthy approaches.
The Channel Impulse Response of SIMO Optical Wireless Communication based on Monte Carlo Simulation

In underwater optical wireless communications (UOWC) the channel impulse response is essential in characterizing the link. In this paper we investigate the impulse response of the single input multiple output UOWC link using Monte Carlo simulation for different types of waters. We simulate the bit error rate (BER) performance for the proposed intensity modulation direct detection SIMO UOWC links for multiple receivers with a linear combining scheme by considering absorption, scattering, turbulence and all major noise sources. We show that, the clear, coastal and harbor waters display the best to the worth BER performance, respectively. Keywords—Underwater optical wireless communications (UOWC), impulse response, single-input multi-output, scattering, turbulence
Extending range and endurance estimates of battery powered electric aircraft

Small electric unmanned aerial vehicles (UAVs) are increasingly used for military and civilian applications. In these applications, range and endurance estimates are of primary importance to assess the suitability of platforms for specific missions. This article looks at the fundamental performance characteristics in a typical electric powertrain consisting of the motor, speed controller, propeller and battery. The behaviour of the battery energy source is investigated and the effect of motor specifications is explored. It is shown that an accurate battery model and a good estimation of the motor no-load current are key to accurate range and endurance estimates.
Comparison of Diadochokinetic Rate between Malayalam and Tamil Native Speakers

Diadochokinetic (DDK) rate represents an index for assessing oro-motor skills. It is commonly used in routine clinical evaluation of diseases of the central nervous system, disturbances of the peripheral sensory motor formations and immaturity of the speech mechanism. Oral DDK rates are a popular guideline for the assessment, diagnosis and treatment of patients with neurological deficit of the speech mechanism. But there is no culture and language specific (Indian Language) normative range for the application of oral DDK task. So the study aims to compare the diadochokinetic rate between Tamil and Malayalam speakers. Hundred healthy adults were recruited for the study within the age range of 20 to 25 years. Participants were grouped based on their native language (G1 & G2) and gender (F & M). The participants were asked to perform both AMR and SMR. The rate was accounted by Time-By-Count method. The result shows there is a significant difference (p<0.001) between the groups. DDK score was found to be higher in Malayalam speakers than Tamil speakers which reflect the faster rate of speech in Malayalam. So the study reflects the need for establishing language specific normative for accurate assessment and diagnosis.
Activation of Na 1 - and Ca 2 1 -dependent Mg 2 1 extrusion by a 1 - and b -adrenergic agonists in rat liver cells

and Romani. Activation of Na 1 - and Ca 2 1 -dependent Mg 2 1 extrusion by a 1 - and b -ad-renergic agonists in rat liver cells. Am J Physiol Gastrointest Liver Physiol 279: G943–G950, 2000. —The administration of selective a 1 (phenylephrine)-, b (isoproterenol)-, or mixed (epinephrine) adrenergic agonists induces a marked Mg 2 1 extrusion from perfused rat livers. In the absence of extracellular Ca 2 1 , phenylephrine does not induce a detectable Mg 2 1 extrusion, isoproterenol-induced Mg 2 1 mobilization is unaffected, and epinephrine induces a net Mg 2 1 extrusion that is lower than in the presence of extracellular Ca 2 1 and quantitatively similar to that elicited by isoproterenol. In the absence of extracellular Na 1 , no Mg 2 1 is extruded from the liver irrespective of the agonist used. Similar results are observed in perfused livers stimulated by glucagon or 8-chlo-roadenosine 3 9 ,5 9 -cyclic monophosphate. In the absence of extracellular Na 1 or Ca 2 1 , adrenergic-induced glucose extrusion from the liver is also markedly decreased. Together, these results indicate that liver cells extrude Mg 2 1 primarily via a Na 1 -dependent mechanism. This extrusion pathway can be activated by the increase in cellular cAMP that follows the stimulation by glucagon or a speciﬁc b -adrenergic receptor agonist or, alternatively, by the changes in cellular Ca 2 1 induced by the stimulation of the a 1 -adrenoceptor. In addition, the stimulation of the a 1 -adrenoceptor appears to activate an auxiliary Ca 2 1 -dependent Mg 2 1 extrusion pathway. Finally, our data suggest that experimental conditions that affect Mg 2 1 mobilization also interfere with glucose extrusion from liver cells.
A hybrid fault diagnosis method for mechanic-electronic-hydraulic control system based on simulated knowledge from virtual prototyping

For the fault diagnosis of mechanic-electronic-hydraulic control system (MEHCS), the main barrier that restricts the application of knowledge-based methods is the lack of historical fault data. Aiming at this problem, this paper proposed a hybrid fault diagnosis method based on simulated knowledge from virtual prototyping. As a special form of mathematical model, virtual prototyping of MEHCS under faulty and nominal condition was established, validated, fault-injected and simulated to obtain simulation data. Fault features of different fault types were extracted, which were then trained by three pattern recognition methods to build the knowledge database for diagnosis. Threshold test and ensemble classifier constituted by the three pattern recognition methods were employed respectively to realize fault detection and isolation. To verify the proposed methodology, a case study of vessel steering system was presented. Fault types of stuck rudder and steady state error were studied. Probabilistic neural network (PNN), naive Bayes (NB), and k-nearest neighbor (kNN) were employed to constitute ensemble classifier based on majority voting. The diagnosis results showed that the accuracy of fault detection and isolation of both fault types were highly acceptable. The ensemble classifier performed better on comprehensiveness and smoothness than any individual pattern recognition method for the overall diagnosis. The proposed method might be an available choice for the fault diagnosis of MEHCS, especially for large-scale and complicated cases.
Impact of Line Mismatch on Two-Wire Deembedding Methods in Early Characterization of Emerging Interconnects

In this paper, we analyze the impact of line mismatch on two-wire deembedding methods in early characterization of emerging interconnects. According to our analysis, mismatch of wires significantly reduces the accuracy of deembedding methods using two test wire structures and causes unexpectedly large error. Therefore, characterizing emerging interconnects with the deembedding methods is not reliable in an early development period when the process variation is large. To help engineers to decide whether the deembedding methods are applicable or not, we theoretically and empirically analyze how line mismatch affects the deembedding accuracy, and derive a condition under which the deembedding methods are reliable.
Neuromanagement e leadership

Il neuromanagement e il campo di ricerca che utilizza gli approcci metodologici delle neuroscienze applicandoli al tema del management. Mentre la leadership e uno dei costrutti piu indagati dal punto di vista classico, dati oggettivi di tipo psicofisiologico sono ancora poco diffusi nel campo della ricerca sul management. L’obiettivo di questo studio pilota e quello di applicare il paradigma dell’Hyperscanning durante un role playing in cui viene simulato un colloquio di valutazione di un collaboratore. Il fine ultimo e quello di identificare pattern lessicali e marker psicofisiologici dell’interazione tra collaboratore e leader. Durante l’esperimento ai manager veniva chiesto di adottare uno stile di leadership autori-tario o cooperativo, con il relativo stile di comunicazione. Attraverso un’analisi semantico-conversazionale sono stati individuati alcuni temi salienti, utilizzati in seguito per analizzare e interpretare i dati. I risultati mostrano come l’intervista sia piu attivante per il collaboratore rispetto al manager. Un aumento delle bande corticali Delta e Theta sembrerebbe mostrare una valenza positiva dei temi del cambiamento personale e della mission aziedale. Le misure autonomiche (Skin Conductance Response e Heart Rate) forniscono inoltre informazioni importanti in relazione al differente stile di leadership e al ruolo assunto all’interno dell’azienda. I risultati sottolineano come l’applicazione delle neuroscienze sia importante all’interno dei contesti organizzativi e nell’esplorazione dei processi di interazione tra collaboratore e leader, soprattutto in relazione allo stile comunicativo e di leadership. In particolare il paradigma di hyperscanning si rivela un ottimo mezzo per indagare le dinamiche interpersonali e i relativi correlati psicofisiologici durante una fase importante della conduzione manageriale: la valutazione dei collaboratori.
An Approach To Cluster And Benchmark Regional Emergency An Approach To Cluster And Benchmark Regional Emergency Medical Service Agencies Medical Service Agencies

Emergency Medical Service (EMS) providers are the first responders for an injured patient on the field. Their assessment of patient injuries and determination of an appropriate hospital play a critical role in patient outcomes. A majority of states in the US have established a state-level governing body (e.g., EMS Division) that is responsible for developing and maintaining a robust EMS system throughout the state. Such divisions develop standards, accredit EMS agencies, oversee the trauma system, and support new initiatives through grants and training. But to do so, these divisions require data to enable them to first understand the similarities between existing EMS agencies in the state in terms of their resources and activities. Benchmarking them against similar peer groups could then reveal best practices among top performers in terms of patient outcomes. While limited qualitative data exists in the literature based on surveys of EMS personnel related to their working environment, training, and stress, what is lacking is a quantitative approach that can help compare and contrast EMS agencies across a comprehensive set of factors and enable benchmarking. Our study fills this gap by proposing a data-driven approach to cluster EMS agencies (by county level) and subsequently benchmark them against their peers using two patient safety performance measures, under-triage (UT) and over-triage (OT). The study was conducted in three phases: data collection, clustering, and benchmarking. We first obtained data related to the trauma-iv
in Children with Mild Malaria Erythrocyte Membrane Protein 1 falciparum Plasmodium T Cell Responses to the + CD4

The immune response against the variant surface Ag Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a key component of clinical immunity against malaria. We have investigated the development and maintenance of CD4 + T cell responses to a small semiconserved area of the Duffy binding–like domain (DBL) a –domain of PfEMP1, the DBL a -tag. Young children were followed up longitudinally, and parasites and PBMCs were isolated from 35 patients presenting with an acute case of uncomplicated malaria. The DBL a -tag from the PfEMP1 dominantly expressed by the homologous parasite isolate was cloned and expressed as recombinant protein. The recombinant DBL a -tag was used to activate PBMCs collected from each acute episode and from an annual cross-sectional survey performed after the acute malaria episode. In this article, we report that CD4 + T cell responses to the homologous DBL a -tag were induced in 75% of the children at the time of the acute episode and in 62% of the children at the following cross-sectional survey on average 235 d later. Furthermore, children who had induced DBL a -tag–speciﬁc CD4 + IL-4 + T cells at the acute episode remained episode free for longer than children who induced other types of CD4 + T cell responses. These results suggest that a wide range of DBL a -tag–speciﬁc CD4 + T cell responses were induced in children with mild malaria and, in the case of CD4 + IL-4 + T cell responses, were associated with protection from clinical episodes. The Journal of Immunology , 2014, 192: 000–000.
MOLECULAR PHYLOGEOGRAPHY OF O N C O M E L A N I A LINDOENSIS (GASTROPODA: POMATIOPSIDAE), THE INTERMEDIATE HOST OF SCHISTOSOMA JAPONICUM IN SULAWESI

Oncomelania lindoensis from Lake Lindu, Sulawesi, was characterized for genetic variation at 21 allozyme loci and compared with O. hupensis (China) and O. quadrasi (Philippines). Genetic distances and interpopulation patterns of allele-sharing point to a closer relationship between Sulawesi and the Philippines (Nei’s unbiased genetic distances ( D ) averaged 0.50) than between Sulawesi and China ( D (cid:53) 0.79). These data, coupled with a consideration of the geographic distribution of the genus, support the hypothesis that the Sulawesi Oncomelania originated by avian-facilitated colonization from the Philippines about two million years ago. Oncomelania from Sulawesi were originally described as subspeciﬁcally distinct: Oncomelania hupensis lindoensis . However, the allopatric distribution, unique alleles at ﬁve loci, and signiﬁcant genetic distances from congeners in Mindanao and elsewhere in the Philippines suggest that this taxon should be distinguished as a full species within the Oncomelania hupensis species group, namely: O. lindoensis Davis & Carney 1973. Comparison with published data on variation within quadrasi and in three Chinese subspecies of hupensis showed that D values increase with taxonomic level in this species group. D averaged 0.15 (0–0.26) within Chinese subspecies and 0.04 (0–0.13) within the Philippines, but was 0.30 (0.20–0.45) between Chinese subspecies, and 0.48–0.80 between the three species ( hupensis, quadrasi and lindoensis ). The genotypic cluster species concept and these multilocus genetic dis- tances can be used to help deﬁne species and subspecies in these medically important snails.
Master of Science Thesis Growth of cracks at rolling contact fatigue

Rolling contact fatigue is a problem encountered with many machine elements. In the current report a numerical study has been performed in order to predict the crack path and crack propagation cycles of a surface initiated rolling contact fatigue crack. The implementation of the contact problem is based on the asperity point load mechanism for rolling contact fatigue. The practical studied problem is gear contact. Different loading types and models are studied and compared to an experimental spall profile. Good agreement has been observed considering short crack lengths with a distributed loading model using normal loads on the asperity and for the cylindrical contact and a tangential load on the asperity. Several different crack propagation criteria have been implemented in order to verify the validity of the dominant mode I crack propagation assumption. Some general characteristics of rolling contact fatigue cracks have been highlighted. A quantitative parameter study of the implemented model has been performed.
LIBRARY AWARD FOR UNDERGRADUATE RESEARCH

In the 18 and 19 centuries, writing of local gazetteers reached its peak in China. To the literati of Guangdong, a wealthy southern province that remained in the eyes of Chinese literati and the ruling bureaucracy a politically remote and culturally different region from the rest of the empire, local gazetteers provided an opportunity for them to make a claim about their dialect, custom, and identity. This study focuses on the Guangdong province in Southern China, and the literati of its two Han Chinese subgroups, the Cantonese and Hakka. It seeks to outline the literary rhetoric of the Cantonese and Hakka literati during the two centuries through the examination of gazetteers, travelogues, and government archives. It pays attention to dialect and customs, not merely as social boundaries, but identity indicators which the Guangdong literati utilized to escape limitations of geographical marginalization and align themselves culturally with the Chinese population outside of Guangdong, and politically with the imperial dynasty that ruled the empire through Confucian orthodoxy.
The signiﬁcance of amino acids and amino acid-derived molecules in plant responses and adaptation to heavy metal stress

Plants exposed to heavy metals accumulate an array of metabolites, some to high millimolar concentrations. This review deals with N-containing metabolites fre-quently preferentially synthesized under heavy metal stress such as Cd, Cu, Ni, and Zn. Special focus is given to proline, but certain other amino acids and oligopeptides, as well as betaine, polyamines, and nicotianamine are also addressed. Particularly for proline a large body of data suggests signiﬁcant beneﬁcial functions under metal stress. In general, the molecules have three major functions, namely metal binding, antioxidant defence, and signalling. Strong correlative and mechanistic experimental evidence, including work with transgenic plants and algae, has been provided that indicates the involvement of metal-induced proline in metal stress defence. Histidine, other amino acids and particularly phytochelatins and glutathione play a role in metal binding, while polyamines function as signalling molecules and antioxidants. Their accumulation needs to be considered as active response and not as consequence of metabolic dys-regulation.