Miracle-dz/UniFAR-FTUs huggingface dataset:
Isolation and characterization of ZK002, a novel dual function snake venom protein from Deinagkistrodon acutus with anti-angiogenic and anti-inflammatory properties

Introduction: Pathological angiogenesis, the abnormal or excessive generation of blood vessels, plays an important role in many diseases including cancer, diabetic retinopathy, psoriasis, and arthritis. Additionally, increasing evidence supports the close linkage between angiogenesis and inflammation. Snake venoms are a rich natural source of biologically active molecules and carry rich potential for the discovery of anti-angiogenic and anti-inflammatory modulators. Methods: Here, we isolated and purified a novel protein, ZK002, from the venom of the snake Deinagkistrodon acutus, and investigated its anti-angiogenic and anti-inflammatory activities and mechanisms. Results: ZK002 was identified as a 30 kDa heterodimeric protein of α and β chains, which exhibited anti-angiogenic activity in various in vitro assays. Mechanistically, ZK002 inhibited activation of VEGF signaling and related mediators including eNOS, p38, LIMK, and HSP27. ZK002 also upregulated the metalloproteinase inhibitor TIMP3 and inhibited components of the VEGF-induced signaling cascade, PPP3R2 and SH2D2A. The anti-angiogenic activity of ZK002 was confirmed in multiple in vivo models. ZK002 could also inhibit the in vitro expression of pro-inflammatory cytokines, as well as in vivo inflammation in the carrageenin-induced edema rat model. Conclusion: Our findings highlight the potential for further development of ZK002 as a dual function therapeutic against diseases with involvement of pathogenic angiogenesis and chronic inflammation.
The effect of discharge training and telephone counseling service on patients’ functional status and caregiver burden after stroke: A randomized controlled trial

Objective: This study aimed to determine the effect of discharge training and telephone counseling service on patients’ functional status and caregiver burden after stroke. Methods: This study was conducted as a randomized controlled trial in 69 stroke patients and their caregivers. Discharge training and telephone counseling were given to the caregivers in the intervention group. Caregivers also received telephone counseling by calling researcher when needed. Information form for participants, Modified Rankin Scale, Barthel Index and The Zarit Caregiver Burden Scale were used for data collection. Pre-tests were applied to the intervention and control groups before discharge. Three months after discharge post-tests were performed for the two groups. Results: Three months after discharge, caregivers’ burden was significantly lower in the intervention group compared to the control group. The mean Modified Rankin Scale score of the patients in the intervention group was significantly lower than the control group three months after discharge. Although the mean Barthel Index score of the patients in the intervention group was statistically significant higher than before discharge, but the difference between the groups was not statistically significant. Conclusion: Discharge training and telephone counseling provided to the caregivers of stroke patients reduced the caregiver burden and had a positive effect on the improvement of the functional status of the patients.
Determination of H2O2 and organic peroxides in cloud‐and rain‐water on the Kleiner Feldberg during FELDEX

This letter reports high-pressure liquid chromatography (HPLC) measurements of H2O2 and organic hydroperoxides in cloud- and rain-water. Observations were conducted on the Kleiner Feldberg (Germany) from late October to late November 1995, within the FELDEX-campaign. It was the first campaign ever in which organic peroxides were determined in cloud-water. H2O2 was found with concentrations of <0.008–3.19 µmol · 1−1. Hydroxymethyl hydroperoxide (HOCH2OOH, HMHP) and 1-hydroxyethyl hydroperoxide (CH3CH(OH)OOH, 1-HEHP) were observed with concentrations in the range of <0.008–1.0 µmol · 1−1 (HMHP) and <0.008–0.28 µmol · 1−1 (1-HEHP). The ratio of the sum of organic peroxides over the total amount of peroxides (H2O2+organic peroxides) was 0–81%. The concentrations of S(IV) and H2O2 in the samples were anticorrelated. The results indicate that organic peroxides, such as HMHP and 1-HEHP, should be included into modelling studies of the aqueous phase oxidation of S(IV).
El acceso vascular en el paciente anciano en hemodiálisis: resultados y supervivencia

Introducción: A pesar de los intentos de la iniciativa “fístula primero”, la realidad es que un porcentaje nada desdeñable de pacientes en hemodiálisis siguen dializándose a través de un catéter, y esto es especialmente relevante en los pacientes ancianos.Objetivos: Conocer y sintetizar la evidencia científica existente sobre los resultados del acceso vascular en el paciente anciano en hemodiálisis. Metodología: Se ha realizado una revisión sistemática en las bases de datos PubMed, Scopus y WOS. Se utilizaron como descriptores los siguientes términos: Hemodiálisis (“Hemodialysis”), Acceso Vascular (“Vascular Access”) y Mortalidad (“Mortality”), combinándolos entre sí utilizando el operador booleano AND. Se incluyeron artículos cuya publicación estuviese comprendida entre 2017 y 2023 en inglés y español. Resultados: Se incluyeron 15 artículos: una revisión y diferentes estudios observacionales. Tras el análisis de estos, se ha evidenciado el incremento del uso de catéteres del paciente anciano, relacionándose con elevadas tasas de infecciones y peor supervivencia. El uso del catéter está relacionado con mayor comorbilidad y edad. Conclusión: La fístula arteriovenosa sigue siendo el acceso vascular de elección en todos los pacientes en hemodiálisis, sin embargo, el uso del catéter ha experimentado un aumento importante en los pacientes ancianos, debido posiblemente a menor esperanza de vida y comorbilidad asociada a estas personas. Este aumento de su utilización se ha relacionado con un aumento importante de la mortalidad. A pesar de ello, en el paciente mayor, no está claro si el aumento de la mortalidad se debe al catéter o a las características basales del paciente.
Hybrid-CVFE method for flexible-grid reservoir simulation

Well flows and pressures are the most important boundary conditions in reservoir simulation. In a typical simulation, rapid changes and large pressure, temperature, saturation, and composition gradients occur in near-well regions. Treatment of these near-well phenomena significantly affects the accuracy of reservoir simulation results; therefore, extensive efforts have been devoted to the numerical treatment of wells and near-well flows. The flexible control-volume finite-element (CVFE) method is used to construct hybrid grids. The method involves use of a local cylindrical or elliptical grid to represent near-well flow accurately while honoring complex reservoir boundaries. The grid transition is smooth without any special discretization approximation, which eliminates the grid transition problem experienced with Cartesian local grid refinement and hybrid Cartesian gridding techniques.
Adaptive dynamic output feedback FTC for nonlinear systems with unknown nonlinearities and faults

The problem of adaptive dynamic output feedback fault tolerant control (FTC) for a class of nonlinear systems with unknown nonlinearities and faults is investigated, in which the nonlinearities do not need to satisfy the Lipschitz condition, so the system can represent a wider range of nonlinear system models. An adaptive dynamic output feedback FTC is designed, where the output and its derivatives are fully applied to compensate the actuator faults on systems. The designed control method can effectively offset the effect of faults on systems so as to stabilized the nonlinear system. Furthermore, based on the designed controller, the coupling term can be eliminated reasonably and less conservative stability conditions for the closed‐loop system have been obtained. The proposed control strategy pledges that the states of the closed‐loop system are uniformly ultimately bounded (UUB). Two numerical examples are presented to exhibit the effectiveness and merits of the proposed control scheme.
Molecular Dynamics Simulations of Periplasmic Proteins Interacting With the Peptidoglycan Layer of Escherichia coli

There has long been interest in using in silico methods to model complex biological systems, such as cells, for self-evident implications in molecular biology and medicine. Molecular dynamics (MD) simulations are ideal for the construction of such models due to the atomic resolution they provide. We use MD in this work to construct and simulate a preliminary model of the periplasmic space, the peptidoglycan layer and its associated proteins, in an E. coli cell. During an initial 23 nanoseconds (ns) MD simulation including 13 of the most abundant periplasmic proteins, the proteins and the peptidoglycan layer were characterized by several interactions. This work provides one of the first steps along the path to creating a complete and comprehensive model of a biological cell.
İnfertil Kadınlara Değişim Aşamaları Modeli ile Yapılan Bireysel Danışmanlık Girişiminin Kilo Yönetimine Etkisi

Objective: Evaluate the effect of individual counseling intervention on weight management based on Stages of Change Model conducted on infertile women. Methods: This study consisted of two stages: counseling and follow-up. The research population consisted of 146 infertile women who applied to the in vitro fertilization center of a state hospital in İzmir between January 4, 2019, and June 22, 2019. Among the 104 infertile women who met the inclusion criteria and declared their willingness to participate in the study, 51 women constituted the intervention group, and 53 women constituted the control group. While an individual counseling program based on Stages of Change Model was conducted on the initiative group, the control group was followed routinely. Research data were analyzed using SPSS 22.0 software. Results: Most recent follow-up anthropometric values of infertile women in the intervention group were lower compared to the pre-follow-up values. The difference between these two data was statistically significant (p = 0.000). Infertile women in the intervention group tended to increase their consumption of daily milk and dairy products and vegetable and fruits in their most recent follow-up stage compared to that in the pre-follow-up stage, whereas their consumption of and daily calories from meat products, sugary products, fats, cereals, and bread decreased. The difference between these two data was statistically significant (p = 0.000). Conclusion: Individual counseling intervention based on Stages of Change Model aiming to evaluate the weight management caused infertile women to adopt healthy behaviors in terms of physical activity and nutritional habits.
Machine learning on crowd-sourced data to highlight coral disease

Triggered largely by the warming and pollution of oceans, corals are experiencing bleaching and a variety of diseases caused by the spread of bacteria, fungi, and viruses. Identification of bleached/diseased corals enables implementation of measures to halt or retard disease. Benthic cover analysis, a standard metric used in large databases to assess live coral cover, as a standalone measure of reef health is insufficient for identification of coral bleaching/disease. Proposed herein is a solution that couples machine learning with crowd-sourced data – images from government archives, citizen science projects, and personal images collected by tourists – to build a model capable of identifying healthy, bleached, and/or diseased coral. We collected hundreds of images of corals from open source archives, including the National Oceanic and Atmospheric Administration’s records and the XL Catlin Seaview Survey. The image annotation platform Labelbox was used to highlight regions of interest in each of these images and label them as “healthy”, “bleached”, “black band disease”, “dark spot disease”, “white syndrome”, or “yellow band disease”. These annotations were then used to build, train, and validate a Python-based image classification model, adapted from an open-source Mask R-CNN (region-based convolutional neural network) algorithm. Use of the model on a test set of coral images yields over 85% accuracy in distinguishing healthy versus unhealthy coral. This machine learning-based model has the potential to rapidly analyze a large and growing database of images to identify coral bleaching/disease around the world, thereby enabling effective allocation of resources for preservation of our marine ecosystems.
Marine algal survey of northeastern Great Barrier Island, New Zealand

Abstract During a nine-day visit, we investigated the algal ecology of Rangiwhakaea Bay,Great Barrier Island, northeastern New Zealand. Four subtidal algal zones were recognised, and these were mapped along with gravel and sand areas. The four algal zones were dominated by Carpophyllum angustijolium, coralline turf and paint, Ecklonia radiata, and Hummbrella hydra respectively. Carpophyllum angustijolium extended up into the low intertidal, its vertical width varying with the degree of wave exposure. Five other intertidal algal zones were observed. They were dominated by Xiphophora chondrophylla, Splachnidium rugosum and Catenellopsis oligarthra, Pachymenia lusoria, Hormosira banksii, and Cigartina alveata. Sixty-six species of algae were recorded from the region.
From Cadomian subduction to Early Palaeozoic rifting: the evolution of Saxo-Thuringia at the margin of Gondwana in the light of single zircon geochronology and basin development (Central European Variscides, Germany)

Abstract Saxo-Thuringia is classified as a tectonostratigraphic terrane belonging to the Armorican Terrane Collage (Cadomia). As a former part of the Avalonian-Cadomian Orogenic Belt, it became (after Cadomian orogenic events, rift-related Cambro-Ordovician geodynamic processes and a northward drift within Late Ordovician to Early Silurian times), during Late Devonian to Early Carboniferous continent-continent collision, a part of the Central European Variscides. By making use of single zircon geochronology, geochemistry and basin analysis, geological processes were reconstructed from latest Neoproterozoic to Ordovician time: (1) 660–540 Ma: subduction, back-arc sedimentation and tectonomagmatic activity in a Cadomian continental island-arc setting marginal to Gondwana; (2) 540 Ma: obduction and deformation of the island arc and marginal basins; (3) 540–530 Ma: widespread plutonism related to the obduction-related Cadomian heating event and crustal extension; (4) 530–500 Ma: transform margin regime connected with strike-slip generated formation of Early to Mid-Cambrian pull-apart basins; (5) 500–490 Ma: Late Cambrian uplift and formation of a chemical weathering crust; (6) 490–470 Ma: Ordovician rift setting with related sedimentation regime and intense igneous activity; (7) 440–435 Ma: division from Gondwana and start of northward drift. The West African and the Amazonian Cratons of Gondwana, as well as parts of Brittany, were singled out by a study of inherited and detrital zircons as potential source areas in the hinterland of Saxo-Thuringia.
Dynamics of a phase change at the base of the mantle consistent with seismological observations

The phase change model for the origin of the D″ seismic discontinuity is tested by comparing the results of convection modeling with seismic observations. We compute a number of global dynamic models that incorporate a phase change at the base of the mantle with different characteristics and transform the resulting temperature field and the distribution of phases to seismic velocities. Over 900 two-dimensional synthetic waveforms are computed for each of the models from which S, ScS, and Scd phases are picked. The distribution of the relative amplitudes and differential travel time residuals for these phases are statistically compared with the distribution of data from four well studied regions (northern Siberia, Alaska, India, and Central America) in a search for the characteristics of a phase transition that best match these seismic observations. We find that the best fit among the models considered is obtained for phase transitions characterized by a Clapeyron slope of ∼6 MPa K−1 and an elevation above the core-mantle boundary of ∼150 km under adiabatic temperature or 127 GPa and 2650 K on a (P,T) diagram. Dynamic models demonstrate that the value of Clapeyron slope and the density difference between the phases can have significant influence on the dynamics of plumes but probably only a minor influence on the dynamics of subducted slabs. We find that the thermal structure of subducted slabs can be important in giving rise to the seismic triplication; the strongest Scd arrivals in our models are observed in the area of subduction. The folding of the slab at the base of the mantle leads to patterns in differential travel time distributions consistent with seismic observations and suggests that the largest heterogeneity occurs at the top of the D″ layer or just above it. Analysis of the spatial autocorrelation functions of the differential travel time residuals suggests that their characteristic peaks reflect the patterns of slab folding and may provide constraints on the rheology of slabs at the base of the mantle.
The Effect of Lyrical and Instrumental Music on Reading Comprehension Tasks

Many studies have investigated if music can impact a person’s productivity, with varying results reported. Some students argue that music is helpful to their work, but some people think otherwise. Studying this topic is important because teachers might play music while students are working to help students be more focused in class. We tested 37 people in four different conditions: silence, instrumental, Spanish, and English music, using four different reading comprehension articles. We found that English lyrical music is not helpful to most students, compared to silence. Foreign and instrumental music did not help or hurt based on our data because there was not a significant difference between them and the silence condition. Therefore, we recommend that students and teachers use foreign language or instrumental music instead of music with English lyrics when working on reading tasks.
S-wave velocity structure of northeastern China from joint inversion of Rayleigh wave phase and group velocities

SUMMARY We imaged the crust and uppermost mantle structure beneath northeastern (NE) China with fundamental mode Rayleigh waves recorded by 125 broad-band stations deployed in the region. Rayleigh wave phase and group velocities along more than 700 interstation paths were estimated using the wavelet transformation method and then these data were utilized to construct 2-D phase and group velocity maps in the period range of 15–60 s. Owing to the dense ray coverage and short ray path, our results provide better lateral resolution in the NE China region compared with previous phase and group velocity studies. The regularized Rayleigh wave phase and group velocity dispersions at each cell were jointly inverted to determine 1-D shear wave velocity structure using the linear inversion method and then assembled into a 3-D model. Our results show that obvious low velocities exist in the uppermost mantle beneath the Changbaishan volcanic region, which may be due to asthenospheric upwelling. The thin lithosphere with fast S-wave velocity in the lower crust of the Songliao Basin implies that the lithospheric mantle beneath NE China is partly removed.
Ameloblastic Fibro-Odontoma of the Posterior Mandible: A Rare Pathological Entity

Ameloblastic fibro-odontoma (AFO) is a rare, slow-growing neoplastic lesion classified as a benign, epithelial mixed odontogenic tumor with odontogenic mesenchyme. This tumor demonstrates the histological features characteristic of both ameloblastic fibromas and complex odontomas. The clinical manifestation of AFO is typically characterized by asymptomatic enlargement of the jawbones. Radiographically, it presents as a distinct radiolucent region, indicating the presence of radiopaque substances with varying degrees of irregularities in size and morphology. Standard therapeutic intervention involves enucleation. Despite its benign nature, AFO can cause significant morbidity if left untreated. Therefore, prompt diagnosis and appropriate management are essential to ensure optimal patient outcomes. The following case report details the clinical presentation and management of an 18-year-old male with an AFO lesion located in the posterior mandible. This particular case was treated with conservative measures involving surgical enucleation.
Pengaruh Promosi Penjualan Dan Kualitas Layanan Terhadap Loyalitas Konsumen Fanatic Coffee Bogor

The growth of coffee shops, especially in the city of Bogor at this time is very rapid, giving rise to trade competition for each coffee shop in order to get consumers who are loyal to the coffee shop itself. Every coffee shop competes to get consumers who are loyal to the coffee shop. The purpose of this study was to analyze the effect of sales promotion and service quality on customer loyalty at Fanatic Coffee Bogor. The number of respondents was 175 respondents who were taken using a questionnaire. Processed with SPSS version 20, the results of the study are (1) Sales Promotion has a positive and partially significant effect of 5.462. (2) Service quality has a positive and partially significant effect of 10.326. (3) Sales Promotion and Service Quality together have a positive and significant effect simultaneously of 188,412 on Customer Loyalty. So it can be concluded that in this study the variables of Sales Promotion, and Service Quality play a role or contribute to Customer Loyalty with an R-square value of 68.7% while the rest is explained by other variables. Keywords : Sales Promotion, Service Quality, Customer Loyalty
Simulation and analysis of edge ghosting for microcapsule e‐paper based on particle dynamics and light scattering model

Electronic paper (e‐paper) is a reflective display technology with unique advantages, such as bistability, low‐power consumption, and high ambient contrast ratio. These features make e‐paper a promising candidate for future Internet of Things applications. Among different technologies of e‐paper, electrophoretic display (EPD) is the most successful one for commercialization. However, the edge ghosting (also known as the fringing effect) still limits the performance of EPD. Herein, we established a model of particle dynamics of electrophoresis, simulated the edge ghosting of microcapsule EPD, analyzed the edge ghosting effect, and revealed the relationship between thicknesses, dielectric constants of the back binder layer, and the edge ghosting. Two EPD panels with different thicknesses of back binder layer were demonstrated, which verifies the accuracy of this simulation model. With the proposed model, many device mechanisms and product issues can be analyzed and illustrated, which is supposed to guide the researchers in optimizing the device structure design of EPD.
Effects of the water retention curve on evaporation from arid soils

Water retention curves approaching infinitely negative matric potentials at residual water content are widely employed to model soil moisture dynamics. When used in numerical simulations, these retention curves fail to satisfactorily describe evaporation from arid soil (moisture‐limited regime) because they do not allow the soil to dry below residual water content. We show that simple modifications can be introduced to prevent unrealistic water retention at residual water content and predict more physically sound moisture dynamics. Modified retention models that allow drying below residual predict a moisture‐limited regime characterized by a thin subsurface evaporation zone and produce vapor fluxes up to 3 times larger than classical retention models. This might reduce the need to introduce empirical enhancement factors and improve the capability of modeling evaporation into the atmosphere and runoff in arid regions.