Miracle-dz/UniFAR-FTUs huggingface dataset:
Prolonged Antiretroviral Treatment Induces Adipose Tissue Remodelling Associated with Mild Inflammation in SIV-Infected Macaques

During chronic SIV/HIV infection, adipose tissue (AT) is the target of both antiretroviral treatment (ART) and the virus. AT might subsequently contribute to the low-grade systemic inflammation observed in patients on ART. To evaluate the inflammatory profile of AT during chronic SIV/HIV infection, we assayed subcutaneous and visceral abdominal AT from non-infected (SIV−, control), ART-naïve SIV-infected (SIV+) and ART-controlled SIV-infected (SIV+ART+) cynomolgus macaques for the mRNA expression of genes coding for factors related to inflammation. Significant differences were observed only when comparing the SIV+ART+ group with the SIV+ and/or SIV− groups. ART-treated infection impacted the metabolic fraction (with elevated expression of PPARγ and CEBPα), the extracellular matrix (with elevated expression of COL1A2 and HIF-1α), and the inflammatory profile. Both pro- and anti-inflammatory signatures were detected in AT, with greater mRNA expression of anti-inflammatory markers (adiponectin and CD163) and markers associated with inflammation (TNF-α, Mx1, CCL5 and CX3CL1). There were no intergroup differences in other markers (IL-6 and MCP-1). In conclusion, we observed marked differences in the immune and metabolic profiles of AT in the context of an ART-treated, chronic SIV infection; these differences were related more to ART than to SIV infection per se.
Dark matter annihilation at cosmological redshifts: possible relic signal from annihilation of weakly interacting massive particles

We discuss the possibility of observing the products of the dark matter annihilation that was going on in the early Universe. Of all the particles that could be generated by this process, we consider only photons, as they are both uncharged and easily detectable. The younger the Universe was, the higher the dark matter concentration n and the annihilation rate (proportional to n2) were. However, the emission from the very early Universe cannot reach us because of the opacity. The main part of the signal was generated at the moment the Universe had just become transparent for the photons produced by the annihilation. Thus, the dark matter annihilation in the early Universe should have created a sort of relic emission. We obtain its flux and the spectrum. If weakly interacting massive particles (WIMPs) constitute dark matter, it is shown that we may expect an extragalactic gamma-ray signal in the energy range 0.5–20 MeV with a maximum near 8 MeV. We show that an experimentally observed excess in the gamma-ray background at 0.5–20 MeV could be created by the relic signal from the annihilation of WIMPs only if the dark matter structures in the Universe had appeared before the Universe became transparent for the annihilation products (z≃ 300). We discuss in more detail physical conditions whereby this interpretation could be possible.
Disc-protoplanet interaction - Influence of circumprimary radiative discs on self-gravitating protoplanetary bodies in binary star systems

Context. More than 60 planets have been discovered so far in systems that harbour two stars, some of which have binary semi-major axes as small as 20 au. It is well known that the formation of planets in such systems is strongly influenced by the stellar components, since the protoplanetary disc and the particles within are exposed to the gravitational influence of the binary. However, the question on how self-gravitating protoplanetary bodies affect the evolution of a radiative, circumprimary disc is still open. Aims. We present our 2D hydrodynamical GPU-CPU code and study the interaction of several thousands of self-gravitating particles with a viscous and radiative circumprimary disc within a binary star system. To our knowledge this program is the only one at the moment that is capable to handle this many particles and to calculate their influence on each other and on the disc. Methods. We performed hydrodynamical simulations of a circumstellar disc assuming the binary system to be coplanar. Our gridbased staggered mesh code relies on ideas from ZEUS-2D, where we implemented the FARGO algorithm and an additional energy equation for the radiative cooling according to opacity tables. To treat particle motion we used a parallelised version of the precise Bulirsch - Stoer algorithm. Four models in total where computed taking into account (i) only N-body interaction, (ii) N-body and disc interaction, (iii) the influence of computational parameters (especially smoothing) on N-body interaction, and (iv) the influence of a quiet low-eccentricity disc while running model (ii). The impact velocities where measured at two different time intervals and were compared. Results. We show that the combination of disc- and N-body self-gravity can have a significant influence on the orbit evolution of roughly Moon sized protoplanets.
A remark on the inviscid limit for two-dimensional incompressible fluids

In this article, we shall study the inviscid limit of two dimensional fluids with bounded voticity. We prove that the solution of incompressible Navier-Stokes system converges strongly in L2 to the solution of the Euler incompressible system in the case of two-dimensional fluids in the whole space.
Glioblastoma with concomitant moyamoya vasculopathy in neurofibromatosis type 1: illustrative case

BACKGROUND In a case of concurrent glioblastoma and moyamoya vasculopathy, it is arduous to safely perform surgery because the brain is highly vulnerable and collaterals are sometimes well developed. In addition, radiotherapy carries a risk of aggravating moyamoya vasculopathy, and chemotherapeutic agents also have a risk of interfering with collateral development. OBSERVATIONS A 48-year-old woman with neurofibromatosis type 1 was admitted because of left hemiparesis and hemispatial neglect. Brain imaging studies revealed a large mass with peripheral enhancement in the right frontal lobe and occlusion of the bilateral middle cerebral arteries with an abnormal vascular network at the base of the brain. Total tumor resection was performed, and the pathological diagnosis was isocitrate dehydrogenase–mutant glioblastoma. Radiotherapy with a total dose of 60 Gy was delivered with concurrent temozolomide, and thereafter six cycles of adjuvant temozolomide were given. Progression of moyamoya vasculopathy without symptoms was observed after the completion of each of radiotherapy and adjuvant temozolomide. LESSONS The authors present the first adult case of glioblastoma with moyamoya vasculopathy. Careful consideration and attention should be given throughout treatment to avoiding moyamoya vasculopathy–related ischemic and hemorrhagic events. Although the patient did not exhibit neurological deterioration, progression of moyamoya vasculopathy occurred early after radiotherapy and continued thereafter.
Brain network dynamics codify heterogeneity in seizure evolution

Abstract Dynamic functional brain connectivity facilitates adaptive cognition and behaviour. Abnormal alterations within such connectivity could result in disrupted functions observed across various neurological conditions. As one of the most common neurological disorders, epilepsy is defined by the seemingly random occurrence of spontaneous seizures. A central but unresolved question concerns the mechanisms by which extraordinarily diverse propagation dynamics of seizures emerge. Here, we applied a graph-theoretical approach to assess dynamic reconfigurations in the functional brain connectivity before, during and after seizures that display heterogeneous propagation patterns despite sharing similar cortical onsets. We computed time-varying functional brain connectivity networks from human intracranial recordings of 67 seizures (across 14 patients) that had a focal origin—49 of these focal seizures remained focal and 18 underwent a bilateral spread (focal to bilateral tonic-clonic seizures). We utilized functional connectivity networks estimated from interictal periods across patients as control. Our results characterize network features that quantify the underlying functional dynamics associated with the observed heterogeneity of seizure propagation across these two types of focal seizures. Decoding these network features demonstrate that bilateral propagation of seizure activity is an outcome of the imbalance of global integration and segregation in the brain prior to seizure onset. We show that there exist intrinsic network signatures preceding seizure onset that are associated with the extent to which an impending seizure will propagate throughout the brain (i.e. staying within one hemisphere versus spreading transcallosally). Additionally, these features characterize an increase in segregation and a decrease in excitability within the brain network (i.e. high modularity and low spectral radius). Importantly, seizure-type-specific differences in these features emerge several minutes prior to seizure onset, suggesting the potential utility of such measures in intervention strategies. Finally, our results reveal network characteristics after the onset that are unique to the propagation mechanisms of two most common focal seizure subtypes, indicative of distinct reconfiguration processes that may assist termination of each seizure type. Together, our findings provide insights into the relationship between the temporal evolution of seizure activity and the underlying functional connectivity dynamics. These results offer exciting avenues where graph-theoretical measures could potentially guide personalized clinical interventions for epilepsy and other neurological disorders in which extensive heterogeneity is observed across subtypes as well as across and within individual patients.
Biologics: how far can they go in Crohn’s disease?

Abstract Crohn’s disease is a chronic gastrointestinal inflammatory disorder, characterized by episodes of relapsing and remitting flares. As the disease mechanism becomes better elucidated, there is a significant increase in the number of available biologic therapies. This article summarizes and synthesizes current Food and Drug Administration-approved biological therapy for Crohn’s disease and examines the positioning of medical therapy as emerging biologics break onto the market.
The use of CRISPR to generate a whole-gene humanized MAPT and the examination of P301L and G272V clinical variants, along with the creation of deletion null alleles of ptl-1, pgrn-1 and alfa-1 loci

To study important genes involved in Frontotemporal Dementia ( MAPT , GRN and C9orf72 ), we created deletion alleles in the three orthologous genes ( ptl-1 , pgrn-1 , and alfa-1 ). Simultaneously, we replaced the C. elegans ptl-1 gene with the predicted orthologous human MAPT gene, often called whole-gene humanization, which allows direct assessment of conserved gene function, as well as the opportunity to examine consequences of clinical disease-associated patient variations. Each gene was manipulated using a different selection strategy, including a novel strategy using an unc-18 mutation rescue technique. Clinical MAPT ALS/FTD missense variants G272V and P301L were successfully inserted in hMAPT . Neither ptl-1 loss or clinical variants caused neuronal defects in young adult or aged C. elegans , based on examination of glutamatergic phasmid neurons. Yet, we noted decreased survival to day 9 in the P301L hMAPT strain, compared to control strains. Based on these results, we comment on strategies for humanization, including the importance of confirming C. elegans gene predictions and identifying loss of function defects for each gene before embarking on humanization, and we report the creation of strains and a new gene-editing selection strategy that will be useful for future studies.
Disparities Education Strategies in the Case Comprehensive Cancer Center STEM Focused Youth Enjoy Science Program

The Youth Enjoy Science/Scientific Enrichment and Opportunity (YES/SEO) Program at Case Western Reserve University (CWRU) School of Medicine and the Case Comprehensive Cancer Center (Case CCC) in Cleveland, OH is an intensive Research, Science, Technology, Engineering, and Mathematics (STEM) program targeted at engaging underrepresented minority high school students to better understand and to pursue careers in cancer research and healthcare. The program’s long-range goals are to increase diversity of the cancer professional workforce to contribute to elimination of cancer health inequities. A challenging aspect of this intensive research and STEM education program is how to effectively teach about cancer health disparities and to address the importance of developing strategies for their remediation. We describe herein some innovative approaches utilized to engage students in learning about disparities and thinking about solutions. Overall, feedback from our students indicates the importance of introducing disparities education topics often and using multiple approaches, including small and large meetings as well as lecture and conversational formats. These approaches provide opportunities for frequent student engagement and concept reinforcement. Based on this experience, a series of recommendations are provided for incorporating disparities education into intensive research and STEM programs.
Experience with and perceptions of non-prescription anthelmintics for cancer treatments among cancer patients in South Korea: A cross-sectional survey

Although non-prescription anthelmintics are used by many patients as cancer treatment in South Korea, data regarding the experiences or perceptions of these drugs are lacking. This study aimed to investigate the repercussions of non-prescription anthelmintics for cancer treatment and evaluate their perceived effectiveness and adverse effects. This survey included 86 cancer patients, aged 19 years and older, who underwent anthelmintic therapy for cancer. They were recruited from two online communities in South Korea through a structured questionnaire that was provided online. Cancer patients under non-prescription anthelmintic therapy for cancer in South Korea were mostly in their advanced stages and had started the treatment in 2019. About half of the cancer patients had taken non-prescription anthelmintics during their chemotherapy, and 96.5% of them did not inform the clinicians. These participants had a positive perception (79.1%) toward the effectiveness of anthelmintics, as they felt it improved their physical condition. Data on the adverse effects of anthelmintics showed that more than two-third of the participants did not report experiencing any adverse effects. Communication between the clinicians and cancer patients regarding the use of non-prescription anthelmintics should be enhanced to prevent adverse effects.
The X-ray Pulsar M82 X-2 on its Propeller Line

{\it NuSTAR} has detected pulsations from the ultraluminous X-ray source X-2 in M82 and archival {\it Chandra} observations have given us a good idea of its duty cycle. The newly discovered pulsar exhibited at least 4 super-Eddington outbursts in the past 15 years but, in its lowest-power state, it radiates just below the Eddington limit and its properties appear to be typical of high-mass X-ray binaries. M82 X-2 has been described as a common neutron star with a 1~TG magnetic field that occasionally accretes above the Eddington rate and as a magnetar-like pulsar with a 10-100~TG magnetic field that reaches above the quantum limit. We argue in favor of the former interpretation. Using standard accretion theory and the available observations, we calculate the stellar magnetic field of this pulsar in two independent ways and we show that it cannot exceed 3~TG in either case. We discuss the implications of our results for other ultraluminous X-ray sources that occasionally exhibit similar powerful outbursts.
Interaction between collisionless galactic discs and non-axisymmetric dark matter haloes

Using $N$-body simulations ($N\sim 10^6 - 10^7$), we examine how a non-axisymmetric dark halo affects the dynamical evolution of the structure in collisionless (stellar) discs. We demonstrate how the model parameters such as mass of the halo, initial conditions in the disc and the halo axes ratio affect morphology and kinematics of the stellar discs. We show that a non-axisymmetric halo can generate a large-scale spiral density pattern in the embedded stellar disc. The pattern is observed in the disc for many periods of its revolution, even if the disc is gravitationally over-stable. The growth of the spiral arms is not accompanied by significant dynamical heating of the disc, irrelevant to its initial parameters. We also investigate transformation of the dark halo's shape driven by the long-lived spiral pattern in the disc . We show that the analysis of the velocity field in the stellar disc and in the spiral pattern gives us a possibility to figure out the spatial orientation of the triaxial-shaped dark halo and to measure the triaxiality.
Reconstruction of orbits of Cantor systems from full groups

In this note, we show that the topological structure of orbits of a Cantor dynamical system, satisfying some mild technical conditions, is completely determined by its full group; namely, we prove that two Cantor systems (X1, G1) and (X2, G2) are orbit equivalent if and only if their full groups are isomorphic as abstract groups. Furthermore, any isomorphism between full groups is generated by a homeomorphism of the underlying spaces. This result is a complete topological analog of the well‐known Dye's theorem proved originally for ergodic measure‐preserving actions. Our results are established for systems having no orbits of length 1 and 2 and such that every open set is intersected by some orbit at least twice.
Plasma‐Substrate Interaction during Plasma Deposition on Polymers

The initial stage of film growth during plasma deposition on polymers determines many film properties such as morphology and structure, interphase formation and adhesion. Therefore, the plasma‐substrate interaction is investigated regarding the energy density during film growth, which is defined by the energy flux per depositing atom. The flux of film‐forming species and the flux of energetic particles were determined for metal sputtering (silver films) and plasma polymer deposition (amino‐functional hydrocarbon films). It is shown that enhanced energy densities can be obtained during the initial film growth due to reduced deposition rates and mixing with the polymer substrate (interphase formation). Thus, good adhesion on polymers such as polyethylene terephthalate (PET) has been achieved. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Flux-Induced Baryon Asymmetry

I propose that the primordial baryon asymmetry of the universe was induced by the presence of a non-vanishing antisymmetric field background H_ijk across the three space dimensions. This background creates a dilute (B-L)-number density in the universe cancelling the contribution from baryons and leptons. This situation naturally appears if the U(1)_{B-L} symmetry is gauged and the corresponding gauge boson gets a Stuckelberg mass by combining with an antisymmetric field B_ij. All these ingredients are present in D-brane models of particle physics. None of the Sakharov conditions are required.
On the stability of black holes at the LHC

The eventual production of mini black holes by proton-proton collisions at the LHC is predicted by theories with large extra dimensions resolvable at the Tev scale of energies. It is expected that these black holes evaporate shortly after its production as a consequence of the Hawking radiation. We show that for theories based on the ADS/CFT correspondence, the produced black holes may have an unstable horizon, which grows proportionally to the square of the distance to the collision point.
A Quantum Optical Scheme to Probe the Decoherence of a Macroscopic Object

We propose a quantum optical version of Schrodinger's famous gedanken experiment in which the state of a microscopic system ~a cavity field! becomes entangled with and disentangled from the state of a massive object ~a movable mirror! Despite the fact that a mixture of Schrodinger cat states is produced during the evolution ~due to the fact that the macroscopic mirror starts off in a thermal state ! , this setup allows us to systematically probe the rules by which a superposition of spatially separated states of a macroscopic object decoheres. The parameter regime required to test environment-induced decoherence models is found to be close to those currently realizable, while that required to detect gravitationally induced collapse is well beyond current technology. @S1050-2947~99! 01405-5# PACS number~s! : 03.65. Bz, 42.50. Vk, 42.50. Dv
A Novel Analysis of CMAP Scans From Perspective of Information Theory: CMAP Distribution Index (CDIX)

<italic>Objective:</italic> The compound muscle action potential (CMAP) scan is a useful technique for examination of neuromuscular disorders. The objective of this study is to develop a novel analysis of CMAP scans from the perspective of information theory. <italic>Methods:</italic> A novel index parameter called CMAP distribution index (CDIX) was developed to characterize CMAP scan based on calculation of the information entropy. The performance of CDIX was evaluated using CMAP scan data from healthy control and spinal cord injury (SCI) subjects, and compared with D50 and MScanFit motor unit number estimation (MUNE). <italic>Results:</italic> CDIX was significantly lower for the SCI subjects compared with the healthy control subjects (p < 0.001). A significant correlation (<inline-formula><tex-math notation="LaTeX">${\mathbf{R}}^2$</tex-math></inline-formula> = 0.58, p < 0.001) was found between CDIX and MScanFit MUNE. Among all tested parameters (maximum CMAP, D50, MScanFit MUNE and CDIX), CDIX achieved the smallest relative width of the overlapping zone (WOZ%) between SCI and healthy control subjects. <italic>Conclusion:</italic> CDIX can be inferred as a useful index reflecting motor unit loss and muscle fiber reinnervation changes.
Dark matter contribution to Galactic diffuse gamma ray emission

Author(s): Yang, LF; Silk, J; Szalay, AS; Wyse, RFG; Bozek, B; Madau, P | Abstract: Observations of diffuse Galactic gamma ray emission (DGE) by the Fermi Large Area Telescope (LAT) allow a detailed study of cosmic rays and the interstellar medium. However, diffuse emission models of the inner Galaxy underpredict the Fermi-LAT data at energies above a few GeV and hint at possible nonastrophysical sources including dark matter (DM) annihilations or decays. We present a study of the possible emission components from DM using the high-resolution Via Lactea II N-body simulation of a Milky Way - sized DM halo. We generate full-sky maps of DM annihilation and decay signals that include modeling of the adiabatic contraction of the host density profile, Sommerfeld-enhanced DM annihilations, p-wave annihilations, and decaying DM. We compare our results with the DGE models produced by the Fermi-LAT team over different sky regions, including the Galactic center, high Galactic latitudes, and the Galactic anticenter. This work provides possible smooth component templates of DM to fit the observational data. The subhalo contributions can be considered to provide statistically meaningful templates and demonstrate how spatial profiles are significantly modified according to different annihilation or decay scenarios. We argue that a subhalo-based approach can help constrain the DM physics. © 2014 American Physical Society.