Miracle-dz/UniFAR-FTUs huggingface dataset:
Aciduria: 3 New Cases and Meta-Analysis of Cerebral Neoplasms in L-2 Hydroxyglutaric

SUMMARY: Increasing evidence suggests that patients with L2-HGA have a predisposition to cerebral neoplasms. This may be related to the pathologic accumulation of L2-HG because high amounts of 2-HG have been found in brain neoplasms that have IDH1 mutations. Our experience, on the basis of 11 previously unreported cases of L2-HGA, 3 of which developed cerebral neoplasms during the course of the disease, also supports an association between L2-HGA and cerebral neoplasms. We conducted a meta-analysis of published data, and we identified 295 patients (including our 11 patients) with L2-HGA. In 14 patients, the metabolic disorder was associated with cerebral neoplasms, suggesting an approximately 5% prevalence rate of CNS neoplasms in patients with L2-HGA; nonethe-less, it may still be an underestimate. L2-HGA is an important disease “model” that provides further evidence to support the recently proposed pathogenetic role of 2-HG in the development of cerebral neoplasms.
Evaluation of Adaptive Radiation Therapy in Treatment of Locally Evaluation of Adaptive Radiation Therapy in Treatment of Locally Advanced Head and Neck cancers Advanced Head and Neck cancers

ABSTRACT Background: Radiation therapy is the mainstay of treatment for locally advanced squamous cell carcinoma of the head and neck. During the course of treatment, intensity-modulated radiation therapy does not compensate for anatomical adjustments or tumor shrinkage. Adaptive radiotherapy may be a proposed solu¬tion to account these changes. Aim of the work: to see how adaptive radiotherapy affects dosimetry and clinical effects in advanced squamous cell carcinoma of the head and neck. Patients and methods: With a provisional diagnosis of locally advanced squamous cell carcinoma of the neck and head, 49 patients were treated with definitive concurrent chemoradiotherpay, with the initial plan improved to deliver 70 Gy. All patients have been resimulated at a median dosage of 42 Gy (range, 37.0-44.1) and shifted to adaptive plan. Results: The median gross target volume and planning target volume increased by 0.74% and 1.66%, respectively, as a result of adaptive replaning. The ipsilateral, contralateral parotid, spinal cord, and brainstem maximum doses had a median reduction of 3.86%, 5.32%, 3.5% and 5.28, respectively. Median reduction in size of ipsilateral and contralateral parotid was 13.62% and 17.68% respectively. With a median 18-month follow-up period varying from (6.5 to 31), The median progression-free survival was not reached, but the cumulative PFS was 89.7% and 70.2% at one year and two years, respectively. The total survival rate at 1 year was 9.8%; at 2 years it was 83%. Conclusion: Adaptive radiotherapy is a promising modality that offers the benefits of decreased radiation dosage to organs at risk and improvement in tumor coverage.
Hydrothermal vent fauna of the western Pacific Ocean: Distribution patterns and biogeographic networks

Deep‐sea hydrothermal vent habitats support a low‐diversity fauna in which most species are unique to the ecosystem. To inform conservation planning around this vulnerable marine ecosystem, we examine species distributions over a wide area to assess the underlying beta‐diversity components and to examine biogeographic patterns. We assess the concept of a highly connected fauna that would repopulate areas of local extinction from distal locations.
The cytotoxicity activity of Borneo-cultivated mulberry against breast cancer
cell (MCF-7): the influence of maturity stages and extraction solvents

Breast cancer is one of the leading causes of death in a part of Borneo, which is Sabah, Malaysia, and worldwide. The anticancer activity of white mulberry (Morus alba Linnaeus) has been widely reported. However, cultivation locations, maturity levels, and extraction solvents could influence their phytochemical and pharmacological activities. The lack of anticancer investigation has hampered the development and potential use of Borneo-grown mulberry as an anticancer agent or source. This study investigated the cell cytotoxicity activity of Malaysia-grown mulberry at two maturity stages (fruits: brackish black fully ripe and red mature; leaves: young and mature) extracted using 70% (v/v) methanol, 60% (v/v) ethanol, and 65% (v/v) acetone, against a human breast cancer cell line (MCF-7). As a result, fruits demonstrated maturity-dependent cytotoxicity decrement as the red mature fruits in 70% (v/v) methanol exerted the strongest cytotoxicity (IC50 = 26.83 mg/mL). Meanwhile, the cytotoxicity of leaves revealed maturity-dependent increment as mature leaves in 60% (v/v) ethanol exhibited the strongest cytotoxicity against MCF-7 (IC50 = 2.45 mg/mL). Their cytotoxicity is possibly correlated to the anticancer-possessing phenolic acids and flavonoids in fruits; and the anticancerpossessing alkaloids and terpenes in leaves. Overall, Sabah-grown mulberry possesses substantial cytotoxicity against MCF-7, suggesting its anticancer potential as a complementary treatment for breast cancer.
Prediksi Finansial Distress pada Salah Satu Bank Konvensional Menggunakan Machine Learning

Financial distress is when a company experiences a shortage or insufficient funds to run the company. Prediction of financial distress is needed to prevent bankruptcy. In this study, financial distress predictions were made based on financial ratios obtained from monthly financial reports from a bank convention, after which the proportion that had the most influence on financial distress was determined. The models used in this study are several machine learning models, namely, Logistic Regression, Support Vector Machine, and Random Forest. Based on the analysis results, the best model for predicting financial pressure is the Random Forest Model, with an accuracy of 96.77%. Based on the best model obtained, namely the Random Forest, it can be determined that the ratio that is very influential on financial distress is the ratio of Total Asset Turnover.
Covert Operations Detection for Maritime Applications

RÉSUMÉ Dans cet article, on décrit le développement et on fait la démonstration d'un processeur COD (Covert Operations Detection) conçu dans le but de fournir une capacité automatisée pour la détection de comportements anormaux et / ou menaçants dans des environnements complexes. La version actuelle utilise des données sur les parcours des navires, obtenues au cours de l'expérience Fleet Battle Experiment, pour faire la démonstration de la capacité de ce système à identifier différents navires basé sur des données de parcours uniquement et pour détecter rapidement un comportement anormal incluant la simulation d'opérations de minage, avec un degré de confiance statistiquement élevé. Le développement de l'algorithme fait appel à une technique qui n'est pas basée sur des modèles et qui est conçue pour offrir une détection robuste des anomalies dans des conditions changeantes. Le processeur est basé sur un algorithme de groupage non dirigé (Self Organizing Map or SOM1) développé par Kohonen (1997)2. Les caractéristiques des données de parcours, comme la répartition des vitesses sur une courte période de temps, sont utilisées pour définir des groupements correspondant à des comportements caractéristiques. Les localisations des groupements dans l'espace multidimensionnel des caractéristiques sont projetées sur une grille dimensionnelle inférieure (i.e. 2-D) pour l'identification efficace des groupements. Les données associées aux groupements isolés ou faiblement peuplés représentent un comportement potentiellement anormal. Les contacts douteux sont signalés automatiquement pour recherche ou action additionnelle. Des efforts sont en cours pour transférer ce potentiel opérationnel à la flotte. La capacité de classification automatique du COD permettra aux commandants de déployer de façon plus efficace ses ressources pour poursuivre, suivre, éviter ou ignorer les multiples contacts trouvés dans l'espace de combat. Le centre d'intérêt est orienté à l'heure actuelle vers les opérations secrètes de minage et autres comportements douteux le long du littoral, mais la technique pourra éventuellement s'étendre à une vaste gamme d'applications incluant le repérage et le suivi des navires à l'échelle du globe, le ciblage en temps critique, le respect des lois en matière de pêche et l'interdiction des drogues.
Emergence of Civilization, Changes in Fluvio‐Deltaic Style, and Nutrient Redistribution Forced by Holocene Sea‐Level Rise

During the mid‐Holocene, the first large‐scale civilizations emerged in lower alluvial systems after a marked decrease in sea‐level rise at 7–6 kyr. We show that as the landscapes of deltas and lower alluvial plains adjusted to this decrease in the rate of relative sea‐level rise, the abundance and location of resources available for human exploitation changed as did the network of waterways. This dynamic environmental evolution contributed to archaeological changes in the three fluvio‐deltaic settings considered herein: Egypt, Mesopotamia, and the Huang He in China. Specifically, an increase in the scale and intensity of agricultural practice, and the focussing of power toward a single city can be interpreted as responses to these environmental changes. Other archaeological observations, and the cultural trajectories leading to the formation of the Primary States also need to be considered in light of these evolving landscapes.
Agglutinated Rhizopods in Lake Erie - Modern Distribution and Stratigraphic Implications

Surficial sediment samples from Lake Erie were examined quantitatively from the presence of agglutinated rhizopods. Preliminary findings indicate that three major faunal assemblages can be defined, roughly corresponding with the three basins of Lake Erie. Assemblage I in the western basin transect in dominated by Difflugia tricuspis with relatively high numbers (>1,000/20 cm 3 ). The central basin transect assemblage II is dominated by Difflugia oblonga with lower total numbers (500/20 cm 3 ) and the eastern basin (assemblage III) by Difflugia urceolata with extreme low numbers ( 3 ). The surface assemblages can be correlated with the decrease in organic carbon, from west to east, through the three basins. From this preliminary work it appears that both modern and fossil agglutinated rhizopods can be an important tool in paleolimnological studies. --Modified journal abstract.
Molecular Docking Study of Ferulic Acid Analog Compounds as Lung Antifibrotic at TGF-β1 Receptors

Pulmonary fibrosis is one of the conditions that occur in Post-COVID Syndrome patients. Development of specific treatment as an agent to treat pulmonary fibrosis is still ongoing. Ferulic acid is a compound that has a potential lung antifibrotic agent through inhibition of TGF-β1-mediated signaling. Molecular docking studies using the AutoDock Tools program version 1.5. 7 were conducted on ferulic acid and its analogs to determine the activity of compounds as antifibrotic. Furthermore, the interaction of the compound with the receptor was visualized using the Discovery Studio 2021 program. The results showed that ferulic acid and its analogs have lower free energy than pirphenidone which is a standard lung antifibrotic drug. 4- benzoyloxy-3-methoxycinnamic acid is the compound that has the greatest activity. The group that contributes to the ligand-receptor interaction is the aromatic group with π interaction. Keywords: Molecular docking, AutoDock, antifibrotic, TGF-β1, ferulic acid
Water Requirement and Crop Coefficient of Different Planting Patterns in Zhangye Area of Gansu Province

According to the data of the field tests conducted in 2007 in Zhangye area of Gansu province,by using Penman-Monteith formula and water balance method of farmland,the article calculated the water requirement and crop coefficient of spring wheat,spring corn and potato in monoculture pattern.The result showed that: the water requirement were different among the three planting patterns,water requirement of spring corn was the highest under sufficient irrigation,the maximum of water requirement coefficient all appeared in the later period of crops growth and development;so far the average crop coefficient in the whole growth period as considered,there was the following order: spring corn(0.96) spring wheat(0.84) potato(0.83). The maximum of crop coefficient all appeared in the middle-later period of crops development. "Single peak" type changeable tendency of crop coefficient in the whole growth period was obviously presented.
Relation between maternal lipid profile and pregnancy Relation between maternal lipid profile and pregnancy complications and perinatal outcomes complications and perinatal outcomes

ABSTRACT Background: Pregnant experiences physiological changes in maternal lipid metabolism to support fetal growth and development. In some cases a maladaptation occurs and exceeds the physiological range and dyslipidemia is recognized, some pregnancies pacing without associated pregnancy alterations and in pregnancies pacing with pathologies. Aim of the study: determine the relationship between maternal lipid profile and pregnancy and perinatal complications. Besides, determine the cut - of value of each lipid profile components for predicting maternal compilations. Patient and Methods: 164 pregnant who attended the Obstetrics and Gynecology department
STATISTICAL CHARACTERIZATION OF CLIMATE TRENDS IN ANNUAL SERIES OF AVERAGE TEMPERATURE AND PRECIPITATION TO THE STATE CAPITAL OF BRAZIL

The objective of this work was to use statistical methods to identify the existence of possible climate trends in annual data of average temperatures and precipitation in the capitals of the Brazilian states. Considering this aim, statistical tests of linear regression and non-parametric tests of MannKendall and Pettitt were employed on the data that is available at the National Institute of meteorology. The information analyzed include time intervals with varying periods depending on the locality studied, although, the data records are mostly distributed between 1961 and 2011. The results indicate that from the 25 capitals considered, there was a 40% positive trend in average temperature, and 88% of the rainfall indexes did not accuse a trend. Key-words: trends, precipitation, average temperature, statistical tests.
Low Income Childhood Pedestrian Injury: Understanding the Disparate Risk

A leading cause of death and injury to children is being struck by a motor vehicle. A disproportionate number of injured child pedestrians are of low socioeconomic status. The relationship between socioeconomic status and pedestrian injury is poorly understood. The existing literature is limited by the lack of pedestrian exposure data, a common measure of risk, and a clear conceptual framework for the interaction between socioeconomic status and pedestrian injury. Another issue is the limited availability of injury data. This paper proposes a model for understanding child pedestrian exposure and risk and its relationship to socioeconomic status. The analysis also identifies the need for additional data and research, and makes specific policy proposals.
The use of digital elevation models in the identification and characterization of catchments over different grid scales

This study examines the ability of well‐known hydrological and geomorphological descriptors and statistics to differentiate between catchments with spatially varying geology, size and shape subject to the same climate in the Northern Territory, Australia. The effect of digital elevation model grid resolution on these statistics is also examined. Results demonstrate that catchment descriptors such as the area–slope relationship, cumulative area distribution and hypsometric curve can differentiate between catchments with different geology and resultant morphology, but catchment network statistics are insensitive to differences in geology. Examination of the effects of digital elevation model grid scale demonstrates that while considerable catchment information can be gained at digital elevation grids greater than 10 m by 10 m, hillslope and hydrological detail can be lost. Geomorphic descriptors such as the area–slope relationship, cumulative area distribution, width function and Strahler statistics were shown to be sensitive to digital elevation model grid scale, but the hypsometric curve was not. Consequently, caution is needed when deciding on an appropriate grid resolution as well as the interpretation and analysis of catchment properties at grid scales greater than that for optimal hillslope and area aggregation definition. Copyright © 2005 John Wiley & Sons, Ltd.
PALEOENVIRONMENTS AND PALEOECOLOGY OF A LOWER TRIASSIC INVERTEBRATE AND VERTEBRATE ICHNOASSEMBLAGE FROM THE RED PEAK FORMATION (CHUGWATER GROUP), CENTRAL WYOMING

ABSTRACT The Lower Triassic Red Peak Formation of the Chugwater Group has long been considered to have an extremely poor paleontological record, although the cause for the apparent dearth of fossils has yet to be been determined. During the course of fieldwork in central Wyoming numerous vertebrate and invertebrate ichnogenera (n ≥ 11) were observed. Vertebrate tracks and trackways representative of dinosauromorph, archosaur, lepidosaur, and testudinate trackmakers were found (cf. Rotodactylus, Chirotherium barthii, Rhynchosauroides, and cf. Chelonipus respectively). An invertebrate ichnoassemblage composed of at least 6 ichnogenera consistent with the Scoyenia ichnofacies were also found (e.g., Diplichnites, Lockeia, Fuersichnus communis, Palaeophycus striatus, cf. Scoyenia, and cf. Scolicia). The majority of these tracks and traces were found in the upper platy facies (upper 10–20 m of the of the Red Peak Formation), which is thought to be no younger than upper Spathian in age. Sedimentary structures, architectural elements, and lateral stratigraphic relationships support the interpretation of floodplain, fluvial, and lacustrine deposition for the upper platy facies in central Wyoming. The Red Peak Formation vertebrate and invertebrate ichnoassemblages, along with their associated depositional environments, are consistent with a fluviolacustrine (continental) setting comparable to those described from Lower to Middle Triassic strata with a Pangean distribution, including the Moenkopi Formation in the southwestern United States. This ichnoassemblage provides the first opportunity to observe paleoecological diversity and associated paleoenvironments within the Lower Triassic of the Chugwater Group.
Synoptically Driven Arctic Winter States

Abstract The dense network of the Surface Heat Budget of the Arctic (SHEBA) observations is used to assess relationships between winter surface and atmospheric variables as the SHEBA site came under the influence of cyclonic and anticyclonic atmospheric circulation systems. Two distinct and preferred states of subsurface, surface, atmosphere, and clouds occur during the SHEBA winter, extending from the oceanic mixed layer through the troposphere and preceded by same-sign variations in the stratosphere. These states are apparent in distributions of surface temperature, sensible heat and longwave radiation fluxes, ocean heat conduction, cloud-base height and temperature, and in the atmospheric humidity and temperature structure. Surface and atmosphere are in radiative–turbulent–conductive near-equilibrium during a warm opaquely cloudy-sky state, which persists up to 10 days and usually occurs during the low surface pressure phase of a baroclinic wave, although occasionally occurs during the high surface pre.
Diversifikasi produk olahan buah mangrove sebagai sumber pangan alternatif masyarakat pesisir Toroseaje, Kabupaten Pohuwato, Provinsi Gorontalo

Baderan DWK, Hamidun MS, Lamangandjo C, Retnowati Y. 2015. Diversification of mangrove fruit-based products as an alternative food source in Toroseaje coastal communities, Pohuwato District, Gorontalo. Pros Sem Nas Masy Biodiv Indon 1 (2): 347- 351. Mangrove forests in the Toroseaje coastal area serving as a buffer zone of Tomini Bay is continuously pressured by anthropogenic activities beyond its carrying capacity. Mangrove forest is ecologically important, as it serves as foraging/feeding ground, spawning ground, and breeding/nursery grounds of fishes, shrimps and other marine organisms which many of them are economically important species. Human may also benefits from mangrove forests as it produces fruits that can be utilized as alternative food sources replacing rice. The nationally popular consumption rice has been overrunning potential use of local food resources, such mangrove fruits. Coastal communities in Toroseaje have not been aware that mangrove fruits can be processed into a variety of food. The development of mangrove fruit-based food is aimed to diversify food sources of Toroseaje communities, relieving the community from the heavy dependence of rice. Field and literature survey with a qualitative approach was conducted to collect primary and secondary data. The study highlights six superior mangrove fruits-based products, namely pia apapi, dodol munto, sweet munto stick, salty munto stick, soneratia crackers and munto flour. There are also three additional products made from mangrove fuits, namely munto cake, munto jelly, and kacang keong munto. Those nine products were made from three mangrove species Avicennia alba (apapi), Bruguiera gymnorrhiza (Munto), and Sonneratia alba.
Acquired Triazole Resistance Alters Pathogenicity-Associated Features in Candida auris in an Isolate-Dependent Manner

Fluconazole resistance is commonly encountered in Candida auris, and the yeast frequently displays resistance to other standard drugs, which severely limits the number of effective therapeutic agents against this emerging pathogen. In this study, we aimed to investigate the effect of acquired azole resistance on the viability, stress response, and virulence of this species. Fluconazole-, posaconazole-, and voriconazole- resistant strains were generated from two susceptible C. auris clinical isolates (0381, 0387) and compared under various conditions. Several evolved strains became pan-azole-resistant, as well as echinocandin-cross-resistant. While being pan-azole-resistant, the 0381-derived posaconazole-evolved strain colonized brain tissue more efficiently than any other strain, suggesting that fitness cost is not necessarily a consequence of resistance development in C. auris. All 0387-derived evolved strains carried a loss of function mutation (R160S) in BCY1, an inhibitor of the PKA pathway. Sequencing data also revealed that posaconazole treatment can result in ERG3 mutation in C. auris. Despite using the same mechanisms to generate the evolved strains, both genotype and phenotype analysis highlighted that the development of resistance was unique for each strain. Our data suggest that C. auris triazole resistance development is a highly complex process, initiated by several pleiotropic factors.