Miracle-dz/UniFAR-FTUs huggingface dataset:
Peroxisome Proliferator-Activated Receptors: A New Ray Of Hope For Parkinson’s Disease

PD (PD) is a debilitating progressive age-related neurodegenerative disorder that negatively impacts bodily movement. It is the second most common type of neurodegenerative disease after Alzheimer's disease. Although the etiology and pathogenesis of PD remain unknown, a vast body of evidence indicates that oxidative stress, inflammation, apoptosis, mitochondrial dysfunction, and proteasomal dysfunction all play a role in the disease's pathogenesis. Because of the multifactorial nature of the disease, current drug treatment can only offer symptomatic relief and cannot stop or delay the disease progression. The Peroxisome proliferator-activated receptors (PPARs) are the member of the receptor’s superfamily called, nuclear receptors, regulates the growth, differentiation of the tissues, inflammation, mitochondrial function, wound healing, lipid metabolism, and glucose metabolism. Several PPAR agonists have recently been shown to protect neurons from oxidative damage, inflammation, and apoptosis in Alzheimer's disease, PD, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis. We review the research on the neuroprotective effects of PPAR agonists in in-vitro and in-vivo models of PD in this paper. Similarly, the pharmacological mechanism of PPAR agonists' neuroprotective effects is examined. Finally, PPAR agonists exert neuroprotective effects by controlling the expression of a set of genes involved in cell survival processes, suggesting that they may be a potential therapeutic target in crippling neurodegenerative diseases like PD. Keywords: Parkinson’s disease, neuroprotective, neuro inflammatory, oxidative stress, PPAR agonist
Comparison Between Color Stability and post bleaching hypersensitivity of Different Bleaching Protocols – Randomized single-blinded Controlled Clinical Trial

Objective: The aim of the study was to investigate color change, color stability and post bleaching hypersensitivity after performing 3 bleaching protocols, (LASER-activated, lightactivated and chemically-activated) at different time intervals. Methods: Patients were randomly assigned into three treatment groups (n=13). Group A received laser bleaching (J.W. Power Bleaching NEXT, 35 % hydrogen peroxide), group B received light-activated bleaching (Philips ZOOM, 25% hydrogen peroxide), and group C received chemical activated bleaching Dash Philips, 30% hydrogen peroxide). Each group received the treatment according to the manufacturer’s recommendations, followed by the desensitizing agent of each kit. Outcome assessment was performed for teeth shade and post bleaching hypersensitivity preoperatively, immediate, three months, and six months post-operatively using a spectrophotometer (Vita Easyshade, Vivadent, Germany). Results: The study showed that there was no significant difference in color change between the three tested groups. LASER-activated bleaching protocol showed no significant difference in median ∆E throughout the study. Light activated bleaching showed decrease in median ∆E three to six months while in chemical-activated bleaching from zero to three months. Post-bleaching hypersensitivity, results showed no significant difference between the three tested groups as all patient experienced pain. Conclusion: All three bleaching methods can be used upon individual’s preference. LASERactivated bleaching group can be satisfactory for patients seeking good results with reduced chair time with color stability over time. Patinets of the three tested groups experienced post-bleaching hypersensitivity.
Physical and Electrical Analysis of Poly-Si Channel Effect on SONOS Flash Memory

In this study, polycrystalline silicon (poly-Si) is applied to silicon-oxide-nitride-oxide-silicon (SONOS) flash memory as a channel material and the physical and electrical characteristics are analyzed. The results show that the surface roughness of silicon nitride as charge trapping layer (CTL) is enlarged with the number of interface traps and the data retention properties are deteriorated in the device with underlying poly-Si channel which can be serious problem in gate-last 3D NAND flash memory architecture. To improve the memory performance, high pressure deuterium (D2) annealing is suggested as a low-temperature process and the program window and threshold voltage shift in data retention mode is compared before and after the D2 annealing. The suggested curing is found to be effective in improving the device reliability.
Mechanics and Dynamics of Ball End Milling

Mechanics and dynamics of cutting with helical ball end mills are presented. The helical ball end mill attached to the spindle is modelled by orthogonal structural modes in the feed and normal directions at the tool tip. For a given cutter geometry, the cutting coefficients are transformed from an orthogonal cutting data base using an oblique cutting model. The three dimensional swept surface by the cutter is digitized using the true trochoidal kinematics of ball end milling process in time domain. The dynamically regenerated chip thickness, which consists of rigid body motion of the tooth and structural displacements, is evaluated at discrete time intervals by comparing the present and previous tooth marks left on the finish surface. The process is simulated in time domain by considering the instantaneous regenerative chip load. local cutting force coefficients, structural transfer functions and the geometry of ball end milling process. The proposed model predicts cutting forces, surface finish and chatter stability lobes, and is verified experimentally under both static and dynamic cutting conditions.
High quality LTCC resonator for voltage-controlled oscillator

Design and technology of microwave conductor lines embedded in low-temperature cofired ceramic (LTCC) multilayer substrates are summarized with a focus on achieving the highest possible quality (Q) factor for a given line inductance. The work was initiated to test the integrability of base station voltage-controlled oscillators (VCOs) in ceramic multilayer substrates. This approach leads to a miniaturization of current versions by a factor of 2 to 4. However, base station specifications for phase noise and hence resonator Q are extremely demanding. Therefore, both the design and the processing technology were optimized. By choosing a twin-line design with two parallel lines vertically separated by a single LTCC layer, Q factors of 90 and 180 have been achieved for integrated 5.5 nH inductors at frequencies of 640 MHz and 1650 MHz, respectively. Application of this result to VCO modules in standard LTCC technology already yields low phase noise levels, e.g., -136 dBc/Hz at 100 kHz offset, which is suitable for base station applications. However, further noise reduction is expected from a dedicated high Q fabrication process that uses conventional via punching and filling steps to replace the ceramic material between the two lines by conductive silver paste. This raises the Q to 120 and 200, respectively, at the two frequencies and adds extra degrees of freedom to LTCC design for low-loss wireless solutions.
Influences on nonlinear judder vibrations of railway brakes

The paper reports on a joined research project of Knorr-Bremse, Siemens Mobility and the Institute of Robotics and Mechatronics. The goal of the project was to analyse the dynamical behaviour of friction brakes for high-speed trains. It was intended to gain insight into possible vibration mechanisms and to assess the potential for lay-out and operation improvements for future light-weight designs. In particular, the frequency range up to 250 Hz has been addressed, since the corresponding excitation is unavoidable at least to some extent and has to be considered when the brake system is designed. The study includes a comprehensive multibody simulation study and its comparison to experimental results at the test rig of Knorr-Bremse in Munich. The simulation model is adapted step by step in order to clearly identify and separate the influences on the dynamical properties of the complete brake system including its mounting. Additionally a minimal model is introduced that demonstrates some characteristics of the brake system. It turned out that the underlying knowledge is essential for the mechanical lay-out, which could be demonstrated by solving a particular vibration problem in an actual high-speed project.
A pattern reconfigurable patch antenna using switched loop structure

A pattern reconfigurable patch antenna using a switched loop structure is presented.The loop structure for switchable radiation pattern is connected with a feeding line of the patch antenna. The proposed antenna is designed to operate at 2.5 GHz band with 4.2 dBi maximum gain for wireless communication. The sizes of the rectangular patch and the ground plane are 28 mm × 28 mm and 50 mm × 60 mm, respectively. The simulation and experimental results show that the antenna radiation pattern can be changed with switch on/off configuration. The average gain value in the switch off case is 4.09 dB less than that of the switch on case over the range of from 30 to 150°. © 2013 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:1325–1328, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27593
270GHz SiGe BiCMOS manufacturing process platform for mmWave applications

TowerJazz has been offering the high volume commercial SiGe BiCMOS process technology platform, SBC18, for more than a decade. In this paper, we describe the TowerJazz SBC18H3 SiGe BiCMOS process which integrates a production ready 240GHz FT / 270 GHz FMAX SiGe HBT on a 1.8V/3.3V dual gate oxide CMOS process in the SBC18 technology platform. The high-speed NPNs in SBC18H3 process have demonstrated NFMIN of ~2dB at 40GHz, a BVceo of 1.6V and a dc current gain of 1200. This state-of-the-art process also comes with P-I-N diodes with high isolation and low insertion losses, Schottky diodes capable of exceeding cut-off frequencies of 1THz, high density stacked MIM capacitors, MOS and high performance junction varactors characterized up to 50GHz, thick upper metal layers for inductors, and various resistors such as low value and high value unsilicided poly resistors, metal and nwell resistors. Applications of the SBC18H3 platform for millimeter-wave products for automotive radars, phased array radars and Wband imaging are presented.
Mixture-based Clustering for the Ordered Stereotype Model

Many of the methods which deal with the reduction of dimensionality in matrices of data are based on mathematical techniques. In general, it is not possible to use statistical inferences or select the appropriateness of a model via information criteria with these techniques because there is no underlying probability model. Furthermore, the use of ordinal data is very common (e.g. Likert or Braun-Blanquet scale) and the clustering methods in common use treat ordered categorical variables as nominal or continuous rather than as true ordinal data. Recently a group of likelihood-based finite mixture models for binary or count data has been developed (Pledger and Arnold, 2014). This thesis extends this idea and establishes novel likelihood-based multivariate methods for data reduction of a matrix containing ordinal data. This new approach applies fuzzy clustering via finite mixtures to the ordered stereotype model (Fernández et al., 2014a). Fuzzy allocation of rows and columns to corresponding clusters is achieved by performing the EM algorithm, and also Bayesian model fitting is obtained by performing a reversible jump MCMC sampler. Their performances for one-dimensional clustering are compared. Simulation studies and three real data sets are used to illustrate the application of these approaches and also to present novel data visualisation tools for depicting the fuzziness of the clustering results for ordinal data. Additionally, a simulation study is set up to empirically establish a relationship between our likelihood-based methodology and the performance of eleven information criteria in common use. Finally, clustering comparisons between count data and categorising the data as ordinal over a same data set are performed and results are analysed and presented.
Wideband internal antenna with coupled feeding for 4G mobile phone

A wideband internal antenna that is composed of a coupled feeding part and four branch lines is presented.The proposed antenna can operate within two wide bands of 0.64–0.99 GHz and 1.65–2.85 GHz which cover 11 service bands including LTE 700/2300/2500, AMPS800, GSM900, DCS1800, PCS, UMTS, WiBro2350, ISM/Bluetooth, and WLAN for the 4G mobile phone. The antenna could be available not only for future 4G service but also for current 2G/3G services. This internal antenna is fabricated within the limits of a 65 × 11 × 7 mm3 volume and suitable for smart phones or personal digital assistant (PDA) applications. The measured results are in agreement with the simulation. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:513–516, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27341
Adherence to a Mediterranean-Style Dietary Pattern and Cancer Risk in a Prospective Cohort Study

A Mediterranean-style diet is a healthy eating pattern that may benefit cancer risk, but evidence among Americans is scarce. We examined the prospective association between adherence to such a diet pattern and total cancer risk. A Mediterranean-style dietary pattern (MSDP) score was derived from a semi-quantitative food frequency questionnaire at exam 5 (1991–1995). Subjects included 2966 participants of the Framingham Offspring Study who were free of prevalent cancer. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for demographic, lifestyle, and anthropometric measures. Cox-models were also used to examine effect modification by lifestyle and anthropometric measures. During 18 years of median follow-up, 259 women and 352 men were diagnosed with cancer. Women with moderate or higher adherence to the MSDP had ≥25% lower risks of cancer than women with the lowest MSDP (HR (moderate vs. lowest): 0.71, 95% CI: 0.52–0.97 and HR (highest vs. lowest): 0.74; 95% CI: 0.55–0.99). The association between MSDP score and cancer risk in men was weaker except in non-smokers. Beneficial effects of the MSDP in women were stronger among those who were not overweight. In this study, higher adherence to MSDP was associated with lower cancer risk, especially among women.
Predicting Purchase Intention towards Battery Electric Vehicles: A Case of Indonesian Market

The emergence of electric vehicles (EV) is inevitable. In Indonesia, EVs in various forms have been introduced to the market. However, the adoption of EV in the Indonesian market is still negligible. The purpose of this paper is to make an early prediction of consumers’ purchase intentions towards EV, particularly battery electric vehicles (BEV), in Indonesia. A multi-criteria decision model based on the analytic network process (ANP) approach has been proposed. There are several main criteria used to explain the purchase/don’t purchase decision towards BEV, namely functionality, emotion, cost of ownership, and car identity. Through a series of pairwise comparisons involving a number of target customers of senior level professionals, their purchase intentions towards BEV have been predicted. The results of this study show that these early wealthy, highly educated consumers have a moderate preference towards purchasing BEV. Their intention to purchase is influenced by criteria as follows: emotion (42.64%), functionality (25.94%), car identity (21.87%), and cost of ownership (9.55%). Even though the invited target customers do not represent the mass market, the findings of this study could help BEV makers in Indonesia choose who the early adopters are and find the BEV product-market fit in order to accelerate the adoption of electric vehicles.
DYNA-TEST simulator for relay testing. II. Performance evaluation

For pt.I see ibid., vol.6, no.4, p.1427 (1991). Evaluation steps undertaken in the analysis of the DYNA-TEST simulator performance are described. The evaluation assumes comparison of the simulator output waveforms obtained using simulated data with the reference waveforms obtained through recording of an actual fault event. Tests are done using specific utility data. Particular attention is given to the system and instrument transformer modeling as well as to the D/A (digital-to-analog) conversion signal reconstruction subsystem characteristics. Particular reference is made to the Houston Lighting and Power (HL&P) system modeling approach. >
The economic impact of malicious code in wireless mobile networks

The paper presents the findings from a study conducted by Mercer Management Consulting into wireless threats. The paper examines wireless technologies and the vulnerabilities that these new technologies bring. It also investigates current and future wireless threats and the reasons why malicious code will spread within wireless environments. Lastly it examines the potential damage, economic impact and critical factors for stopping wireless attacks.
Sumoylation regulates central spindle protein dynamics during chromosome segregation in oocytes

Meiotic spindles in most species lack centrosomes and the mechanisms that underlie faithful chromosome segregation in acentrosomal meiotic spindles are not well understood. In C. elegans oocytes, spindle microtubules exert a poleward force on chromosomes dependent on the microtubule-stabilising protein CLS-2CLASP. The kinase BUB-1Bub1 and CLS-2CLASP localise in the central-spindle and display a dynamic localisation pattern throughout anaphase but the signals regulating their anaphase-specific localisation remains unknown. We have shown that SUMO regulates BUB-1 localisation during metaphase I. Here, we found that SUMO modification of BUB-1Bub1 is regulated by the SUMO E3 ligase GEI-17 and the SUMO protease ULP-1. SUMO is required for BUB-1 localisation in between segregating chromosomes during early anaphase I, and SUMO depletion partially phenocopies BUB-1Bub1 depletion. We also show that CLS-2CLASP is subject to SUMO-mediated regulation. Over-all, we provide evidence for a novel, SUMO-mediated control of protein dynamics during early anaphase I in oocytes.
Complex effects of telecouplings on forest dynamics: an agent-based modeling approach

Rural areas are increasingly subject to the effects of telecouplings (socioeconomic-environmental interactions over distances) whereby their human and natural dynamics are linked to socioeconomic and environmental drivers operating far away, such as the growing demand for labor and ecosystem services in cities. Although there have been many studies evaluating the effects of telecouplings, telecoulplings in those studies were often investigated separately and how telecoulplings may interact and affect dynamics of rural coupled human and natural systems (CHANS) jointly was rarely evaluated. In this study, we developed an agent-based model and simulated the impacts of two globally common telecouplings, nature-based tourism and labor migration, on forest dynamics of a rural CHANS, China’s Wolong Nature Reserve (Wolong). Nature-based tourism and labor migration can facilitate forest recovery, and the predicted forest areas in Wolong in 2030 would be reduced by 26.2 km2 (6.8%) and 23.9 km2 (6.2%), respectively, without their effects. However, tourism development can significantly reduce the probability of local households to have member(s) out-migrate to work in cities and decrease the positive impact of labor migration on forest recovery. Our simulations show that the interaction between tourism and labor migration can reduce the potential forest recovery by 3.5 km2 (5.0%) in 2030. Our study highlights that interactions among different telecouplings can generate significant impacts on socioeconomic and environmental outcomes and should be jointly considered in the design, management, and evaluation of telecouplings for achieving sustainable development goals.
Tranexamic Acid, a Low-cost and Practical Hemostatic Agent Against Diffuse Microvascular Bleeding Due to Coagulopathy in Heart Surgery

DOI: 10.32596/ejcm.galenos. 2019.00003 Research Article Address for Correspondence: Kenan Abdurrahman Kara, Yeditepe University Hospital, Clinic of Cardiovascular Surgery, İstanbul, Turkey Phone: +90 530 065 52 25 e-mail: kenankaradoc@gmail.com ORCID ID: orcid.org/0000-0003-1295-7689 Received: 02.02. 2019 Accepted: 21.02. 2019 Cite this article as: Kara KA, Öntaş H. Tranexamic Acid, a Low-cost and Practical Hemostatic Agent Against Diffuse Microvascular Bleeding Due to Coagulopathy in Heart Surgery. EJCM 2019;7(1):16-21. DOI: 10.32596/ejcm.galenos. 2019.00003 ©Copyright 2019 by Heart and Health Foundation of Turkey (TÜSAV) / E Journal of Cardiovascular Medicine published by Galenos Publishing House.
Polarization resolved, complete characterization of 1310 nm fiber pigtailed multiple-quantum-well optical amplifiers

A new method allowing an automated, polarization resolved, complete characterization of fiber pigtailed semiconductor optical amplifiers is presented and discussed. The method is applied to a high performance, polarization insensitive 1310 nm strained layer multiple-quantum-well semiconductor optical amplifier. For this amplifier 36 dB fiber to fiber gain, a 3 dB gain saturation output power of 15 dBm and a noise figure of 6.5 dB are demonstrated and the polarization dependence of these key performance figures is clarified. The result is presented in a form which should enable the end-user to derive realistic performance figures which will be obtained for a fluctuating random input signal state of polarization.
Screening for Escherichia albertii in children with gastroenteritis in Pediatric Hospital at Assiut University

1 Aliaa M.A. Ghandour*, 1 Rawhia Fathy, 2 Rania M. Bakry, 3 Shaban M. Sror, 4 Marwa A Sabet, 5 Eman M. Abdelrahman, 1 Mona H. Abdel-Rahim 1 Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Assiut, Egypt 2 Department of Oncological Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt 3 Gastroenterology and Hepatology Unit, Pediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt 4 Department of Microbiology and Immunology, Faculty of Pharmacy, Sphinx University, New-Assiut, Egypt 5 Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt
Performance Improvement Strategies for Discrete Wide Bandgap Devices: A Systematic Review

Wide bandgap (WBG) devices are becoming increasingly popular due to their excellent material properties. WBG devices are commercially available in discrete and module packages. Many studies have investigated the design, structure and benefits of module packages. However, a comprehensive and in-depth overview of the discrete package is lacking. Discrete package has the advantages of flexibility, scalability and reduced cost; however, challenges of severe switching oscillations and limited current capacity are associated with it. This review encompasses the switching oscillations and limited current capacity issues of discrete devices. Switching oscillations are categorized in terms of voltage. The underlying oscillation mechanisms are explored in detail. For the current imbalance, the types, root causes and adverse effects in parallel-connected discrete devices application are reviewed. Besides, the most recent techniques to extract stray parameters are also explored. Finally, state-of-the-art methods to mitigate the switching oscillations and the current imbalance are summarized and evaluated. The performance improvement strategies discussed in this paper can assist researchers to better use the discrete package and can stimulate them to come up with new solutions.