Miracle-dz/UniFAR-FTUs huggingface dataset:
An adjustable Brownian heat engine

A microscopic heat engine is modeled as a Brownian particle in a sawtooh potential (with load) moving through a highly viscous medium driven by the thermal kick it gets from alternately placed hot and cold heat reservoirs. We found closed form expression for the current as a function of the parameters characterizing the model. Depending on the values these model parameters take, the engine is also found to function as a refrigerator. Expressions for the efficiency as well as for the refrigerator performance are also reported. Study of how these quantities depend on the model parameters enabled us in identifying the points in the parameter space where the engine performs either with maximum power or with optimized efficiency. The corresponding efficiencies of the engine are then compared with those of the endoreversible and Carnot engines.
Exploring the Role of Lipid-Binding Proteins and Oxidative Stress in Neurodegenerative Disorders: A Focus on the Neuroprotective Effects of Nutraceutical Supplementation and Physical Exercise

The human brain is primarily composed of lipids, and their homeostasis is crucial to carry on normal neuronal functions. In order to provide an adequate amount of lipid transport in and out of the central nervous system, organisms need a set of proteins able to bind them. Therefore, alterations in the structure or function of lipid-binding proteins negatively affect brain homeostasis, as well as increase inflammation and oxidative stress with the consequent risk of neurodegeneration. In this regard, lifestyle changes seem to be protective against neurodegenerative processes. Nutraceutical supplementation with antioxidant molecules has proven to be useful in proving cognitive functions. Additionally, regular physical activity seems to protect neuronal vitality and increases antioxidant defenses. The aim of the present review was to investigate mechanisms that link lipid-binding protein dysfunction and oxidative stress to cognitive decline, also underlining the neuroprotective effects of diet and exercise.
Abdominal and Pelvic Computed Tomography for the Diagnosis of ST-Elevation Myocardial Infarction: The Challenges of Acute Coronary Syndrome in Diabetic Patients

Diabetes mellitus (DM) is a major independent risk factor for cardiovascular disease. Patients who present with the metabolic emergency of diabetic ketoacidosis (DKA) have similar symptoms of diaphoresis, nausea, emesis, and abdominal pain, which can conceal acute coronary syndrome (ACS). We present a unique case where computed tomography (CT) of the abdomen and pelvis with IV contrast played an integral role in diagnosing an acute myocardial infarction in a patient with no typical ischemic symptoms. A 56-year-old female presented to the emergency department with abdominal pain, nausea, and vomiting. She was suspected of having DKA. Aggressive management was started, including weight-based appropriate IV regular insulin. A CT abdomen and pelvis with IV contrast was performed due to persistent abdomen pain. This demonstrated severe hypoattenuation of the posteroinferior aspect of the left ventricular wall. An EKG was immediately performed and was consistent with an inferior STEMI. The patient was taken to the interventional cardiology suite where they found the culprit lesion to be mid-circumflex with 100% stenosis. This case highlights many important lessons in approaching diabetic patients who are presenting with DKA. DM is associated with cardiac autonomic neuropathy (CAN), a condition that greatly influences perceived chest pain. While little is known about this condition, some manifestations include resting tachycardia, exercise intolerance, orthostatic hypotension, and an increased risk of silent myocardial infarction. Critically, providers must maintain a low threshold to assess for cardiac ischemia in diabetic patients and more readily obtain EKGs in triage as well as during the patient’s course in the ED to prevent complications from delayed ACS care.
Elementary Mathematics Specialists as Emergent Informal Teacher Leaders in Urban Schools: Engagement and Navigations

ABSTRACT This 5-year mathematics professional development project involves 27 elementary teachers prepared and supported as Elementary Mathematics Specialists (EMSs) in high-need, urban schools. The EMSs are a distinctive population as informal teacher leaders, with a primary responsibility of teaching students. Described here are data collected at the end of Year 1 via a survey of coaching practices, a teacher leader record, and individual and focus group interviews. The findings illuminate the variety of ways they were serving as a more knowledgeable other and practicing agency in this teacher leadership. They were agentic in their teacher leader efforts by navigating constraints through: focusing on incremental changes; developing collegial, trusting relationships with peers; and leaning into the network of teacher support in the project. The findings also provide insights into how their primary and concurrent role as teacher of students provided credibility and understanding with fellow teachers, contributing to affordances in their informal teacher leader capacity.
Effective, Long-Term, Neutrophil Depletion Using a Murinized Anti-Ly-6G 1A8 Antibody

Neutrophils are crucial innate immune cells but also play key roles in various diseases, such as cancer, where they can perform both pro- and anti-tumorigenic functions. To study the function of neutrophils in vivo, these cells are often depleted using Ly-6G or Gr-1 depleting antibodies or genetic “knockout” models. However, these methods have several limitations, being only partially effective, effective for a short term, and lacking specificity or the ability to conditionally deplete neutrophils. Here, we describe the use of a novel murinized Ly-6G (1A8) antibody. The murinized Ly-6G antibody is of the mouse IgG2a isotype, which is the only isotype that can bind all murine Fcγ receptors and C1q and is, therefore, able to activate antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent phagocytosis (ADCP) and complement-dependent cytotoxicity (CDC) pathways. We show that this mouse-Ly-6G antibody shows efficient, long-term, and near-complete (>90%) neutrophil depletion in the peripheral blood of C57Bl6/J, Balb/c, NXG and SCID mice for up to at least four weeks, using a standardized neutrophil depletion strategy. In addition, we show that neutrophils are efficiently depleted in the blood and tumor tissue of IMR32 tumor-bearing SCID mice, analyzed six weeks after the start of the treatment.
Recent Advances and Challenges in Implementing IPM Programmes in the Entomological Context of Indian Agriculture

Integrated pest management (IPM) programmes are based on using multiple methods to maintain nuisance insects below tolerant levels in crop fields. Recent advances in IPM in developed countries have incorporated biological pesticides, microbial products, semiochemicals, and beneficial insects, but few of such programmes have been successfully implemented in developing countries, such as India. Semiochemicals play critical roles as signals in various interspecific and intraspecific interactions between insects and plants, and among interacting insects, plants, and microbes. In India IPM programmes have included mechanical, chemical, cultural, and biological management strategies. However, among these methods, biological management has its own limitations. Indian IPM scientists mostly work on individual crops, assessing damage severity by specific nuisance arthropods and the efficacy of particular management measure. However, very few government institutions or commercial companies are engaged in developing and commercializing either biological pesticides or semiochemicals. Government institutions mostly focus on research on pheromones of the pestiferous Lepidoptera and Coleoptera. Developing IPM programmes requires a clear understanding of crop-plant development, biology and population dynamics of the nuisance organisms, and the chemical and molecular interactions between the two. It also necessarily requires local knowledge of available, prevalent management tactics. Moreover, the IPM programmes have not been widely adopted in developing countries due to lack of proper knowledge and training farmers in efficient IPM practices, the need for more of human labour, and the complexity of IPM practices, all of which impede on the effective implementation of IPM programmes. In this article, we recapture the historical development of IPM efforts in India and ask whether this concept remains suitable to the present-day challenges in crop production. In this review, more specifically, those factors identified as obstacles to the more widespread adoption of IPM and ways of overcoming such barriers are discussed.
Free and interacting short-range entangled phases of fermions: Beyond the tenfold way

It is well-known that sufficiently strong interactions can destabilize some SPT phases of free fermions, while others remain stable even in the presence of interactions. It is also known that certain interacting phases cannot be realized by free fermions. We systematically study both of these phenomena in low dimensions and determine the map from free to interacting SPT phases for an arbitrary unitary symmetry G. In particular, in dimension zero and one we describe precisely which SPT phases can be realized by free fermions. We show that in dimension three there are no non-trivial free fermionic SPT phases with a unitary symmetry. We also describe how to compute invariants characterizing interacting phases for free band Hamiltonians with symmetry G (in any dimension) using only representation theory.
High-TC superconductivity induced by magnetic interactions

In this paper, a microscopic theory of magnetic-interaction-induced pairing in superconductivity of high temperature superconductors (HTSC) was developed on the basis of four idealized assumptions: (1) only a small number of electrons(or holes) are involved in superconductivity, and its density is n{\delta}^2; (2) magnetic interactions between electron spins lead to superconductivity; (3) there are different electronic states, i.e., the on-site doubly-occupied electrons forming anti-ferromagnetic insulator states, the off-site doubly-occupied electrons forming superconducting states, the singly-occupied (spin up or down) electrons forming normal states and the empty states; (4) the average kinetic energy of electrons (or holes) complies with the equipartition theorem of energy. Based on these assumptions, an approximate effective Hamiltonian was suggested. A parabolic relation between T_C and the doping concentration {\delta} was found and thus the phase diagram for HTSC has been explained. It was also found that, T_C is related to the anti-ferromagnetic interaction energy J (or critical magnetic field B_C) and the degrees of freedom of electrons i. The T_C values are thus calculated from this theory to be 92.8K for YBa2Cu3O6.15, 40.3K for La2CuO4, and 58K for SmOFeAs, which are in good agreement with the experimental results of 92K, 40K, and 54K, respectively. It was estimated that, T_C in the slab HTSC is higher than that in the bulk, and T_C for SmOFeAs can be up to 116K.
Comparative screening of cadmium stress responses among three rice cultivars

Plants are frequently confronted with heavy metal stress, which is one of the major environmental concerns in agriculture. Cadmium is a potent toxic and hazardous soil contaminant that is introduced into the atmosphere by industrial pollution. It can impose detrimental effects on plant growth, crop productivity and quality. To evaluate Cd-induced physio-biochemical stress response, a comparative study was conducted with three rice (Oryza sativa L.) cultivars (‘Maharaj’, ‘Pratiksha’ and ‘Khitish’) treated with 10 µM CdCl2. Cytotoxicity assessments were performed to determine cell death rates. The study confirmed that cv. ‘Maharaj’ was the most Cd stress tolerant due to high proline, phytochelatin, and antioxidant concentration, resulting in lower cell death rate. Cv. ‘Pratiksha’ was moderately tolerant while cv. ‘Khitish’ was more susceptible to Cd stress, showing drastic reduction in cysteine and sugar concentration, and Hill activity, with noticeable increase of lipid peroxidation, methylglyoxal and starch concentration.
Low-order model for successive bifurcations of the fluidic pinball

We propose the first least-order Galerkin model of an incompressible flow undergoing two successive supercritical bifurcations of Hopf and pitchfork type. A key enabler is a mean-field consideration exploiting the symmetry of the mean flow and the asymmetry of the fluctuation. These symmetries generalize mean-field theory, e.g. no assumption of slow growth rate is needed. The resulting five-dimensional Galerkin model successfully describes the phenomenogram of the fluidic pinball, a two-dimensional wake flow around a cluster of three equidistantly spaced cylinders. The corresponding transition scenario is shown to undergo two successive supercritical bifurcations, namely a Hopf and a pitchfork bifurcation on the way to chaos. The generalized mean-field Galerkin methodology may be employed to describe other transition scenarios.
Lattice Boltzmann method at finite Knudsen numbers

A modified lattice Boltzmann model with a stochastic relaxation mechanism mimicking "virtual" collisions between free-streaming particles and solid walls is introduced. This modified scheme permits to compute plane channel flows in satisfactory agreement with analytical results over a broad spectrum of Knudsen numbers, ranging from the hydrodynamic regime, all the way to quasi-free flow regimes up to Kn ~ 30.
The Structure of Halo Gas around M33

Abstract Understanding the distribution of gas in and around galaxies is vital for our interpretation of galaxy formation and evolution. As part of the Arecibo Galaxy Environment Survey (AGES) we have observed the neutral hydrogen (HI) gas in and around the nearby Local Group galaxy M33 to a greater depth than previous observations. As part of this project we investigated the absence of optically detected dwarf galaxies in its neighbourhood, which is contrary to predictions of galaxy formation models. We observed 22 discrete clouds, 11 of which were previously undetected and none of which have optically detected counterparts. We find one particularly interesting hydrogen cloud, which has many similar characteristics to hydrogen distributed in the disk of a galaxy. This cloud, if it is at the distance of M33, has a HI mass of around 107 M⊙ and a diameter of 18 kpc, making it larger in size than M33 itself.
RE-VISIT OF HST FUV OBSERVATIONS OF THE HOT-JUPITER SYSTEM HD 209458: NO Si iii DETECTION AND THE NEED FOR COS TRANSIT OBSERVATIONS

The discovery of O i atoms and C ii ions in the upper atmosphere of HD 209458b, made with the Hubble Space Telescope Imaging Spectrograph (STIS) using the G140L grating, showed that these heavy species fill an area comparable to the planet’s Roche lobe. The derived ∼10% transit absorption depths require super-thermal processes and/or supersolar abundances. From subsequent Cosmic Origins Spectrograph (COS) observations, C ii absorption was reported with tentative velocity signatures, and absorption by Si iii ions was also claimed in disagreement with a negative STIS G140L detection. Here, we revisit the COS data set showing a severe limitation in the published results from having contrasted the in-transit spectrum against a stellar spectrum averaged from separate observations, at planetary phases 0.27, 0.72, and 0.49. We find variable stellar Si iii and C ii emissions that were significantly depressed not only during transit but also at phase 0.27 compared to phases 0.72 and 0.49. Their respective off-transit 7.5% and 3.1% flux variations are large compared to their reported 8.2 ± 1.4% and 7.8 ± 1.3% transit absorptions. Significant variations also appear in the stellar line shapes, questioning reported velocity signatures. We furthermore present archive STIS G140M transit data consistent with no Si iii absorption, with a negative result of 1.7 ± 18.7 including ∼15% variability. Silicon may still be present at lower ionization states, in parallel with the recent detection of extended magnesium, as Mg i atoms. In this frame, the firm detection of O i and C ii implying solar or supersolar abundances contradicts the recent inference of potential 20–125× subsolar metallicity for HD 209458b.
Protective Effect of Hydroalcoholic Extract of Clove on Thioacetamide-Induced Hepatotoxicity Animal Model: Effects Hydroalcoholic Extract of Clove Against Hepatotoxicity.

BACKGROUND The drug-induced liver injury (DILI) has a wide range of clinical presentations, from asymptomatic liver enzyme elevations to cirrhosis. Herbal dietary supplements may be beneficial to reduce the risk of hepatotoxicity. This study aimed to evaluate the effects of different doses of clove extracts on humoral factors in rats with hepatotoxicity induced by thioacetamide. MATERIALS AND METHODS In this experimental study, rats were divided into nine groups (10 rats per each). The Control group received no treatment. The Sham group was treated with oral administration of distilled water (0.5 ml) for 21 days. The positive control group received thioacetamide (50 mg/kg for three days) intraperitoneally. The clove group was divided into three subgroups and given daily oral administrations of 50, 150, and 300 mg/kg of clove hydroalcoholic extracts (for 21 days). Rats in the experimental group were divided into three subgroups and subjected to 50 mg/kg thioacetamide injection after receiving hydroalcoholic extracts of clove (50, 150, and 300 mg/kg, respectively) for 21 days in the last three days. All rats were sacrificed after 48 hours to measure liver function parameters (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total plasma protein, and albumin). RESULTS The rats that received thioacetamide showed liver damage by increased serum liver biomarkers and decreased levels of total plasma protein and albumin compared to the control group. The different doses of clove extract resulted in a significant improvement of liver damage by reduced serum liver enzymes levels and increased total plasma protein and albumin. CONCLUSION Oral administration of the different doses of the clove extract (50, 150, and 300 mg/kg) for 21 consecutive days could significantly improve the changes associated with serum biomarkers of hepatotoxicity. [GMJ.2022;11:e1603].
A Step-By-Step Tutorial for Performing a Moderated Mediation Analysis using PROCESS

Interest in moderation and mediation models have gained momentum since the 1980s and have become widespread in numerous ﬁelds of research including clinical, social, and health psychology in addition to behavioral, educational, and organizational research. There are resources available to help the user understand an analysis of a moderated mediation using the PROCESS macro and its resultant output, however, many are in video format (e.g., YouTube) or lack detailed instructions based on real world examples. To our knowledge, there are no resources that provide a thorough yet accessible step-by-step explanation of the procedure involved in using PROCESS v4.1 to analyze and interpret a moderated mediation model using real data in SPSS v28. The aim of this guide is to address this knowledge gap. An overview of mediation, moderation, and moderated mediation models is presented followed by instructions for verifying that assumptions are respected. Finally, a procedure to analyze data using PROCESS v4.1 is presented along with an interpretation of the resultant output.
The X-Ray Luminosity Function of Ultraluminous X-Ray Sources in Collisional Ring Galaxies

Ring galaxies are fascinating laboratories: a catastrophic impact between two galaxies (one not much smaller than the other) has produced fireworks, especially in the larger one, when hit roughly perpendicularly to the plane. We analyze the point sources produced by the starburst episode following the impact in the rings of seven galaxies and determine their X-ray luminosity function (XLF). In total, we detect 63 sources, of which 50 have luminosity LX ≥ 1039 erg s−1, classifying them as ultraluminous X-ray sources (ULXs). We find that the total XLF is not significantly different from XLFs derived for other kinds of galaxies, with a tendency of having a larger fraction of high X-ray luminosity objects. Both the total number of ULXs and the number of ULXs per unit star formation rate are found in the upper envelope of the more normal galaxies distribution. Further analysis would be needed to address the issue of the nature of the compact component in the binary system.
Leaders' Networking Behaviours in a Time of Crisis: A Qualitative Study on the Frontline against COVID‐19

Abstract What do leaders do when they interact with followers and stakeholders in a time of crisis? What networking behaviours do leaders manifest in such a context of emergency? We answer these questions through qualitative research and cluster analysis conducted on a sample of leaders involved in community management in the most affected region in northern Italy during the three key phases of the COVID‐19 pandemic. Our findings span a period of 18‐months and show that leaders display a behavioural repertoire that includes six networking actions. Grouped together, these actions identify three clusters of leaders: Churners, who engage mainly in network generation and network termination; Divergent leaders, who manifest high levels of network conflict and re‐construal; and Sense‐makers, who are high in network deepening and teleology. Our research contributes to unveil the idiographic micro‐foundations of networking behaviour during organizational jolts.
Prevalence of Polypoidal Choroidal Vasculopathy in Eyes with Neovascular Age-Related Macular Degeneration Resistant to Intravitreal Anti-VEGF Treatment

Objectives: To determine the prevalence of polypoidal choroidal vasculopathy (PCV) in intravitreal (IV) anti-vascular endothelial growth factor (anti-VEGF)-resistant neovascular age-related macular degeneration (nvAMD) cases. Materials and Methods: Eyes that were diagnosed as having active and treatment-naive nvAMD in the Ege University Ophthalmology Department, Retina Unit in 2011-2018, were non-responsive to IV anti-VEGF treatment, and for which indocyanine angiography (ICGA) could be obtained were included in the study. Active nvAMD was defined as the presence of fresh hemorrhage on clinical examination or findings of subretinal, intraretinal, or sub-retinal pigment epithelial fluid on spectral domain optical coherence tomography and accompanying fluorescein dye leakage in fluorescein angiography. Eyes that had activation findings despite at least 6 consecutive intravitreal anti-VEGF injections were defined as non-responders and underwent ICGA to assess for PCV. The diagnosis of PCV was based on the Everest II study criterion. Results: A total of 97 eyes of 88 patients were included in the study. Of 88 patients, 44 (50%) were female, 44 (50%) were male, and the mean age was 75.9±8.3 years (range: 59-93). The mean number of anti-VEGF injections until the time of ICGA was 7.3±2.2 (range: 6-15). PCV was detected in 62 eyes (63.9%) on ICGA. Conclusion: The prevalence of PCV is quite high among eyes with IV anti-VEGF treatment-resistant nvAMD in Turkey (63.9%). ICGA evaluation for PCV should be conducted for all nvAMD cases that are non-responsive to IV anti-VEGF treatment, both to shed light on the reason for resistance and to modify treatment as necessary.