Miracle-dz/UniFAR-FTUs huggingface dataset:
Unexpected inconsistency of cranial MRI and cranial US measurements: new normative values in the neonatal period

Cranial ultrasonography (US) enables diff erentiation of normal from abnormal in a reasonable scanning time and without radiation. However, there is not enough data comparing measurements of cranial US and magnetic resonance imaging (MRI) for some intracranial structures in the neonatal period. We aimed to assess the reliability of cranial US compared with brain MRI. We also sought reference values of the pituitary gland and infundibulum, which is important in searching for growth retardation or abnormal growth in this population. Normative measurements of the width of the 4th, 3rd and lateral ventricles, length and width of the corpus callosum (CC), biventricular width (BVW), and biparietal diameter (BPD) were prospectively obtained from 95 healthy fullterm neonates on both cranial US and brain MRI. Besides the well-known structures, the height of the pituitary gland, thickness of the infundibulum, height and width of the cerebellum were measured on MRI. Comparison of cranial US and brain MRI showed good correlation in the BPD, width of the splenium and genu of CC, anteroposterior length of CC, and width of the 3rd ventricle (κ=0.880.99). Correlation was poor in BVW, width of the corpus of CC, and width of the lateral ventricles (κ=0.28-0.56). New normative values of the height of pituitary gland and thickness of the stalk in the neonatal period are novel fi ndings of this prospective study. In conclusion, cranial US and MRI measurements were not consistent in some brain structures. It is crucial to know the normative values, and to diff erentiate congenital and developmental brain anomalies in the neonatal period. The new reference values of the pituitary gland and infundibulum were also established in this period.
OTT_A_272596 11839..11848

1Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Central Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China Introduction: Forkhead box (FOX) superfamily members were recently shown to play important roles in tumor development and progression. Forkhead box S1 (FOXS1), a member of the FOX family, has been reported to be closely associated with malignant neoplasms. However, its expression and effect on hepatocellular carcinoma remain unclear. The aim of this study was to determine the expression and role of FOXS1 in hepatocellular carcinoma (HCC). Methods: Real-time PCR, Western blot and immunohistochemistry assays were carried out to determine FOXS1 expression in HCC tissues and cells. The biological roles of FOXS1 in HCC were investigated using CCK-8, colony formation, transwell and wound healing. Additionally, the effect of FOXS1 on epithelial–mesenchymal transition (EMT) was investigated by Western blotting. Xenograft model was carried out to evaluate the effect of FOXS1 in vivo. Results: In our study, we confirmed lower FOXS1 expression in HCC samples than in normal liver tissues by performing Western blotting, immunohistochemistry and real-time PCR assays. In addition, FOXS1 expression is strongly associated with the prognosis of patients with HCC. Overexpression of FOXS1 suppressed cell proliferation, colony formation, the epithelial–mesenchymal transition (EMT) and the hedgehog (Hh) signaling pathway in vitro and in vivo. SAG, an activator of Hh signaling, partially reversed the effect of FOXS1 overexpression on HCC cells. Conclusion: FOXS1 might suppress HCC cell proliferation, colony formation, and EMT by inhibiting the Hh signaling pathway, indicating that FOXS1 may be a promising biological target in HCC.
Epstein-Barr Virus (EBV) Is Mostly Latent and Clonal in Angioimmunoblastic T Cell Lymphoma (AITL)

Simple Summary Angioimmunoblastic T cell lymphoma (AITL) is the most common peripheral T cell lymphoma encountered in Europe. It is a non-Hodgkin’s lymphoma with a poor prognosis. The Epstein-Barr virus (EBV) virus is detected in more than 90% of biopsies, especially in large B lymphocytes. To date, the role of EBV in this pathology is still debated. The aim of our study was to analyze whole viral genomes in AITL compared to other EBV-associated lymphomas. We observed that two viral strains were mainly found in AITL, one of which appeared to be associated with poor post-diagnosis survival. Furthermore, the virus was found to be clonal and latent in all cases of AITL; for one biopsy, the virus was both latent and most likely replicative, depending on the cells. On the whole, these results support a role for EBV in AITL. Abstract The Epstein-Barr virus (EBV) is associated with angioimmunoblastic T cell lymphoma (AITL), a peripheral T lymphoma of poor prognosis in at least 90% of cases. The role of EBV in this pathology is unknown. Using next-generation sequencing, we sequenced the entire EBV genome in biopsies from 18 patients with AITL, 16 patients with another EBV-associated lymphoma, and 2 controls. We chose an EBV target capture method, given the high specificity of this technique, followed by a second capture to increase sensitivity. We identified two main viral strains in AITL, one of them associated with the mutations BNRF1 S542N and BZLF1 A206S and with mutations in the EBNA-3 and LMP-2 genes. This strain was characterized in patients with short post-diagnosis survival. The main mutations found during AITL on the most mutated latency or tegument genes were identified and discussed. We showed that the virus was clonal in all the AITL samples, suggesting that it may be involved in this pathology. Additionally, EBV was latent in all the AITL samples; for one sample only, the virus was found to be latent and probably replicative, depending on the cells. These various elements support the role of EBV in AITL.
THE WESTERN CHIMPANZEE (PAN TROGLODYTES VERUS) IN THE ANTENNA ZONE (NIOKOLO KOBA NATIONAL PARK, SENEGAL): NESTING ECOLOGY AND SYMPATRICS WITH OTHER MAMMALS

The western chimpanzee (Pan troglodytes verus) is “Critically Endangered” due to a gradual decrease of its population and a continuous degradation of their habitats. Niokolo Koba National Park is considered an important biodiversity area in West Africa and has high conservation value for western chimpanzees. However, Niokolo Koba National Park has been inscribed on the World Heritage list as being in Danger since 2007 due to anthropogenic factors. Over the last 40 years, only sporadic and shortterm studies on the ecology and behavior of chimpanzees in the park have occurred. For this reason, we studied the nesting ecology of a putative chimpanzee community in the Antenna zone. We also identified sympatric medium and large mammals using a camera trap. Chimpanzees mostly used Hexalobus monopetalus for nesting, followed by Pterocarpus erinaceus. Nest heights in the Antenna zone were lower than they are in Assirik, and outside the park at Fongoli and Diaguiri sites despite the presence of potential predators in the park. Predator presence influences nesting height behavior. These data deepen our knowledge about chimpanzees in Senegal, and are useful for the management plan of the park and will contribute to an action plan for their conservation there.
Effects of Early Life Exposure to Sex Hormones on Neurochemical and Behavioral Responses to Psychostimulants in Adulthood: Implications in Drug Addiction

Early life exposure to sex hormones affects several brain areas involved in regulating locomotor and motivation behaviors. Our group has shown that neonatal exposure to testosterone propionate (TP) or estradiol valerate (EV) affected the brain dopamine (DA) system in adulthood. Here, we studied the long-lasting effects of neonatal exposure to sex hormones on behavioral and neurochemical responses to amphetamine (AMPH) and methylphenidate (MPD). Our results show that AMPH-induced locomotor activity was higher in female than male control rats. The conditioned place preference (CPP) to AMPH was only observed in EV male rats. In EV female rats, AMPH did not increase locomotor activity, but MPD-induced CPP was observed in control, EV and TP female rats. Using in vivo brain microdialysis, we observed that AMPH-induced extracellular DA levels were lower in nucleus accumbens (NAcc) of EV and TP female rats than control rats. In addition, MPD did not increase NAcc extracellular DA levels in EV rats. Using in vivo fast-scan cyclic voltammetry in striatum, MPD-induced DA reuptake was higher in EV than control rats. In summary, our results show that early life exposure to sex hormones modulates mesolimbic and nigrostriatal DA neurons producing opposite neurochemical effects induced by psychostimulant drugs in NAcc or striatum.
The attachment opioid antagonist drug of Naltrexone to multi-walled carbon nanotubes by different kinds of reagents carbodiimides

Surface functionalization of multi-walled carbon nanotubes(MWCNTs) by opioid antagonist drug of Naltrexone via chemical modification of carboxyl groups,using of reagents di cyclohexyl carbodiimide(DCC),1-ethyl-3[3-dimethylaminopropyl] carbodiimide hydrochloride(EDC),N-hydroxysuccinimide(NHS),1-hydroxybenzotriazolemonohydrate(HOBT),O-(Benzotriazole-1-yl)-1,1,3,3-tetramethyluraniumtetrafluoroborate(TBTU),were performed. In synthetic organic chemistry,compounds containing the carbodiimide functionality are dehydration agents and are often used to activate carboxylic acids towards amide or ester formation. Carboxylic acids will react with the carbodiimide to produce the key intermediate as O-acylisourea which can be considered as a carboxylic ester with an activated leaving group.We have used of five carbodiimide reagent to synthesis twelve sample in this work.The resulting materials were characterized by different techniques,such as Fourier transform infraredspectroscopy (FT-IR), Thermogravimetricanalysis (TGA),Raman spectroscopy,Scanning Electron Microscopy (SEM),Field Emission Scanning Electron Microscopy(FESEM),Atomic Force Microscopy(AFM),High performance liquid chromatography(HPLC).
Detection of aflatoxin-producing fungi in maize

Maize samples (n = 110) were collected from five different areas of Dinajpur district from July 2018 to July 2019 for the detection of aflatoxin-producing fungi and aflatoxin. Aflatoxin-producing fungi were detected using culture and morphological features, and aflatoxin was detected using Agra Strip total aflatoxin test (20 ppb cut-off). Aspergillus spp. were detected in 56% of fresh and 23.2% of stored maize samples. Aflatoxin-producing fungi were detected in 28% of fresh samples and aflatoxin was detected in 10% of stored samples. Out of 110 maize samples, Aspergillus spp was identified in 38.2%, and aflatoxinproducing fungus was found in 18.2%. The presence of aflatoxin-producing fungus in stored maize increased significantly (P<0.01) with storage. In 20 samples aflatoxin level was more than 20 ppb. The Bangladesh Veterinarian (2020) 37(1 - 2): 27-35
Bonding of Clear Aligner Composite Attachments to Ceramic Materials: An In Vitro Study

Background: We aim to evaluate the effect of surface conditioning, bonding agents and composite types on surface roughness (SR) and shear bond strength (SBS) of clear aligner composite attachments bonded to ceramics. Methods: One hundred and eighty IPS e.max CAD specimens were prepared. For SR, 60 specimens were divided according to surface conditioning (n = 15) into four groups: control, 9.6% hydrofluoric acid (HFA), 37% phosphoric acid (PhA), air abrasion (AA). SR was measured using a Profilometer and Atomic Force Microscopy. For SBS, 120 specimens were divided according to conditioning methods (n = 40) (9.6% HFA and 37% PhA or AA), then according to bonding agents (n = 20) (Assure universal bond (AUB) or Single bond universal (SBU)) and then according to composite type (n = 10): Filtek™ Z350 and Filtek™ Z350 XT flowable composite. SBS was measured using Instron testing machine. Descriptive and group comparison were calculated (p < 0.05). Results: AA had the highest SR, while the control had the lowest SR (p < 0.05). HFA had the highest, but insignificant SBS, followed by AA (p > 0.05). AUB had higher SBS than SBU (p < 0.001). Filtek™ Z350 produced higher SBS than Filtek™ Z350 XT flowable composite (p < 0.01). Conclusion: The combination of AA, AUB, and Filtek Z350 produced the highest SBS, followed by HFA, AUB, and Filtek Z350.
An Enactive–Ecological Model to Guide Patient-Centered Osteopathic Care

Osteopaths commonly face complexity and clinical uncertainty in their daily professional practice as primary contact practitioners. In order to effectively deal with complex clinical presentations, osteopaths need to possess well-developed clinical reasoning to understand the individual patient’s lived experience of pain and other symptoms and how their problem impacts their personhood and ability to engage with their world. We have recently proposed (En)active inference as an integrative framework for osteopathic care. The enactivist and active inference frameworks underpin our integrative hypothesis. Here, we present a clinically based interpretation of our integrative hypothesis by considering the ecological niche in which osteopathic care occurs. Active inference enables patients and practitioners to disambiguate each other’s mental states. The patients’ mental states are unobservable and must be inferred based on perceptual cues such as posture, body language, gaze direction and response to touch and hands-on care. A robust therapeutic alliance centred on cooperative communication and shared narratives and the appropriate and effective use of touch and hands-on care enable patients to contextualize their lived experiences. Touch and hands-on care enhance the therapeutic alliance, mental state alignment, and biobehavioural synchrony between patient and practitioner. Therefore, the osteopath–patient dyad provides mental state alignment and opportunities for ecological niche construction. Arguably, this can produce therapeutic experiences which reduce the prominence given to high-level prediction errors—and consequently, the top-down attentional focus on bottom-up sensory prediction errors, thus minimizing free energy. This commentary paper primarily aims to enable osteopaths to critically consider the value of this proposed framework in appreciating the complexities of delivering person-centred care.
Early Callsign Highlighting using Automatic Speech Recognition to Reduce Air Traffic Controller Workload

The primary task of an air traffic controller (ATCo) is to issue instructions to pi-lots. However, the first verbal communication contact is often initiated by the pi-lot. Hence, the ATCo needs to search for the aircraft radar label that corresponds to the callsign uttered by the pilot. Therefore, it would be useful to have a control-ler assistance system, which recognizes and highlights the spoken callsign in the ATCo display as early as possible, directly from the speech data. Therefore, we propose to use an automatic speech recognition (ASR) system to first obtain the speech-to-text transcription, followed by extracting the spoken callsign from the transcription. As a high performance in callsign recognition is required, we use surveillance data, which significantly reduces callsign recognition error rates. When using ASR transcriptions for ATCo utterances of Isavia data (HAAWAII project ), we initially obtain a callsign recognition error rate of 6.2%, which im-proves to 2.8% when surveillance data information is used.For the ATC operational speech data obtained from NATS air navigation service provider for London approach area, currently we obtain a callsign recognition rate of 93.8% for both ATCo and pilot utterances on automatic transcriptions which are generated by an ASR system with a word error rate of 5.1%. However, when surveillance data is not used, the callsign recognition rate drops significantly to 82.7%, indicating the importance of using surveillance data while recognizing callsigns. Once the callsign is spoken, we are able to recognize it within a second, which would be of great value to ATCos especially in situations of high traffic constituting high workload.
The Validity of Machine Learning Procedures in Orthodontics: What Is Still Missing?

Artificial intelligence (AI) models and procedures hold remarkable predictive efficiency in the medical domain through their ability to discover hidden, non-obvious clinical patterns in data. However, due to the sparsity, noise, and time-dependency of medical data, AI procedures are raising unprecedented issues related to the mismatch between doctors’ mentalreasoning and the statistical answers provided by algorithms. Electronic systems can reproduce or even amplify noise hidden in the data, especially when the diagnosis of the subjects in the training data set is inaccurate or incomplete. In this paper we describe the conditions that need to be met for AI instruments to be truly useful in the orthodontic domain. We report some examples of computational procedures that are capable of extracting orthodontic knowledge through ever deeper patient representation. To have confidence in these procedures, orthodontic practitioners should recognize the benefits, shortcomings, and unintended consequences of AI models, as algorithms that learn from human decisions likewise learn mistakes and biases.
A Balanced-to-Single-Ended Wilkinson Power Divider

A balanced-to-single-ended (BTSE) Wilkinson power divider of planar microstrip structure is proposed in this paper. It has a balanced input and two single-ended outputs. Cascade of a balun and a conventional power divider can be replaced by this proposed structure. Based on mixed-mode S-matrix, admittance matrix and ABCD matrix, the critical parameters are determined. The four-port network is analyzed by simplifying it to two-port network with other ports matched at the central frequency. Then the key parameters are derived and the impact of a freely selected variable on the bandwidth is also discussed. An example of 2.4GHz BTSE power divider is designed. The simulated and measured results show the effectiveness of the method: differential-mode transmissions are better than -3.25dB, common-mode transmissions are lower than -28.6dB, common-mode return loss is -0.10dB, differential-mode return loss and isolation is lower than -23.7dB. While the operating bandwidth is 20%.
A methodology for analyzing data from long-term passive acoustic monitoring.

SÁNCHEZ-GENDRIZ, I. A Methodology for analyzing data from long-term passive acoustic monitoring. 2017. 97 f. Doctoral dissertation (Doctorate Candidate in Science. Concentration Area: Control Engineering and Mechanics Automation) – Escola Politécnica (POLI/USP), São Paulo. Despite the extensive Brazilian coast areas, little is known on underwater acoustic environments in Brazil. Acoustic environments (or soundscape) are composed by biological, geological and man-made sound sources. Soundscapes are strongly linked to ecosystems dynamics, and follow temporal patters that can vary at daily and seasonal scales. Thus, for soundscape characterization, it is necessary to undertake sound recordings for long periods, which demands innovative analyzing methods. Accordingly, the present research focuses in two principal objectives: (1) to develop methods for analyzing long-term acoustic recordings and, (2) to characterize marine soundscapes of selected points in Sao Paulo State. Four deployment sites were selected for the underwater acoustic monitoring: a point located at the channel entrance of the Santos Harbor, and three marine Protected Areas (PAs) in Sao Paulo state. As a result, the largest underwater acoustic database from Brazilian seas was acquired. The present work used Power Spectral Density (PSD), Sound Pressure Level (SPL) and Spectrograms to develop an innovative methodology for analyzing long-term acoustic data. In addition, a new visualization tool and a method for automatic detection of dawn and dusk choruses are presented. The achieved results validated the proposed methodology as an effective tool for analyzing long-term acoustic data. The area close to the first site, the vicinity of Santos Harbor, was dominated by ship noise, which values reach levels that can affect some species of fish and marine mammals. The soundscapes of the other three remaining measurement sites were dominated by fish and crustacean choruses, with daily and seasonal patterns (related to sunrise and sunset). For the monitored regions, the present work signifies the first contribution for cataloguing fish choruses, and establishes a baseline for the study of their underwater acoustic environment. Although the proposed methodology has used long-term undersea acoustic datasets as case-study, it can also be extended for monitoring other aquatic or terrestrial ecosystems. Finally, the research indicates to Brazilian environmental agencies and to the related scientific community that passive acoustic monitoring is a noninvasive and cost-effective tool that can be used for the management of PAs and points of economic relevance. Key-words: Big Data, passive acoustic monitoring, soundscape, data processing, digital son processing.
Factors Affecting Total Quality Management Implementation in the Construction Industry

Total quality management (TQM) is an organisation idea that regularly enhances the superiority of products as well as services by concentrating on the customers’ necessities and desires to improve customer satisfaction. This paper aimed to review previous literatures on various issues affecting TQM implementation in the construction industry such as absence of benchmarking, employee confrontation to change, absence of understanding, inadequate preparation, absence of top management obligation, absence of customer focus, absence of rewards and acknowledgment, inadequate evaluation processes, insufficient fund, inefficient management, inadequate raw materials, lack of proper communication and unproductive leadership. This research source for information through recognised articles in journals, conference papers, government reports and so on. The findings from the extensive literature review form previous studies are cross-sectional. According to the previous research, it was revealed that those challenges of total quality management are vary. It is recommended that construction stakeholders should always avoid any obstacle that can affect total quality management in the construction industry.