Miracle-dz/UniFAR-FTUs huggingface dataset:
Limited Effects of Ultra-low Oxygen Concentration during Extended Embryo Culture on In vitro Fertilisation Outcomes in Indian Women: A Retrospective Cross-sectional Study

ABSTRACT Background: Amongst various other factors, oxygen (O2) concentration in embryo culture plays an important role in determining pregnancy outcomes in women undergoing in vitro fertilisation. Some studies have reported that lowering O2 levels in embryo culture provides better results. Aims: To explore the effects of low- and ultra-low- O2 concentrations (5% and 2%, respectively) in extended embryo culture on various outcome parameters of pregnancy. Settings and Design: This was a retrospective cross-sectional study. Materials and Methods: In this study 382 participants had their embryos cultured in varying O2 concentrations (5% or 2%), followed by either a fresh embryo transfer (ET) or frozen embryo transfer (FET). Outcomes such as pregnancy rate, implantation rate, abortion rate, twinning rate, and live birth rate were compared between the groups. Statistical Analysis Used: Chi square test was applied to compare the primary and secondary outcomes between different groups. Results: No significant differences were observed in pregnancy rate and implantation rate between 5% and 2% O2 groups, irrespective of their mode of ET. The abortion rate was significantly higher in 5% O2 group than in 2% group during FET (24.71% vs. 11.49%, P = 0.02). While the proportion of good-quality embryos was higher in 5% O2 group, these did not translate to better pregnancy outcomes. Additionally, embryos cultured in 2% O2 concentration had a significantly better implantation rate when they were transferred fresh rather than frozen (71.34% vs. 61.46%, P = 0.04). There were no other differences observed. Conclusion: Only marginal benefits were observed in switching human embryos to ultra-low O2 concentration after the initial days of culture.
Deferasirox Targeting Ferroptosis Synergistically Ameliorates Myocardial Ischemia Reperfusion Injury in Conjunction With Cyclosporine A

Background Ferroptosis, an iron‐dependent form of regulated cell death, is a major cell death mode in myocardial ischemia reperfusion (I/R) injury, along with mitochondrial permeability transition‐driven necrosis, which is inhibited by cyclosporine A (CsA). However, therapeutics targeting ferroptosis during myocardial I/R injury have not yet been developed. Hence, we aimed to investigate the therapeutic efficacy of deferasirox, an iron chelator, against hypoxia/reoxygenation‐induced ferroptosis in cultured cardiomyocytes and myocardial I/R injury. Methods and Results The effects of deferasirox on hypoxia/reoxygenation‐induced iron overload in the endoplasmic reticulum, lipid peroxidation, and ferroptosis were examined in cultured cardiomyocytes. In a mouse model of I/R injury, the infarct size and adverse cardiac remodeling were examined after treatment with deferasirox, CsA, or both in combination. Deferasirox suppressed hypoxia‐ or hypoxia/reoxygenation‐induced iron overload in the endoplasmic reticulum, lipid peroxidation, and ferroptosis in cultured cardiomyocytes. Deferasirox treatment reduced iron levels in the endoplasmic reticulum and prevented increases in lipid peroxidation and ferroptosis in the I/R‐injured myocardium 24 hours after I/R. Deferasirox and CsA independently reduced the infarct size after I/R injury to a similar degree, and combination therapy with deferasirox and CsA synergistically reduced the infarct size (infarct area/area at risk; control treatment: 64±2%; deferasirox treatment: 48±3%; CsA treatment: 48±4%; deferasirox+CsA treatment: 37±3%), thereby ameliorating adverse cardiac remodeling on day 14 after I/R. Conclusions Combination therapy with deferasirox and CsA may be a clinically feasible and effective therapeutic approach for limiting I/R injury and ameliorating adverse cardiac remodeling after myocardial infarction.
LockBit Black Ransomware On Reverse Shell: Analysis of Infection

This research was conducted due to the widespread occurrence of ransomware attacks, especially in Indonesia, against data that is at the endpoint and has even reached the banking sector. to estimate the likelihood of future ransomware infections. LockBit 3 ransomware aka LockBit Black is ransomware that has penetrated one of the banks in Indonesia, along with a reverse shell which is an infection method that cannot be recognized by every protection so that when combined it can penetrate all sides of protection. The method used to research the combination of ransomware and reverse shell is a hybrid analysis with a combination of static and dynamic analysis, to see every capability that can be carried out by the LockBit Black ransomware and channeled through the reverse shell. In this research, we can see the real impact of the attack and estimate protection in the future from the results of this analysis so that variant ransomware attacks from LockBit can be overcome.
Why Was the Indian Ocean Dipole Weak in the Context of the Extreme El Niño in 2015

AbstractThe Indian Ocean witnessed a weak positive Indian Ocean dipole (IOD) event from the boreal summer to autumn in 2015, while an extreme El Nino occurred over the tropical Pacific. This was different from the case in 1997/98, when an extreme El Nino and the strongest IOD took place simultaneously. The analysis here suggests that the unique sea surface temperature anomaly (SSTA) pattern of El Nino in 2015 might have contributed to the weak IOD that year. El Nino in 2015 had a complex SSTA pattern, with positive warming over the central and eastern tropical Pacific. Such a combination of the classic El Nino (also known as cold-tongue El Nino) and the recently identified central Pacific El Nino (also known as El Nino Modoki II) had opposite remote influences on the tropical Indian Ocean. The classic El Nino reduced the strength of the Walker circulation over the tropical Indian Ocean, but this was offset by El Nino Modoki II. This study points out that the IOD can be strongly modulated by combined El Ni.
Understanding Studies on Consumers’ Food Choices Using Food Choice Questionnaire: A Scoping Review and Bibliometric Analysis (ScoRBA)

Since the development of the food choice questionnaire (FCQ) to assess consumers’ food choice motives in 1995, studies using the FCQ have been highly diverse. Despite the abundance of research on the topic, FCQ nevertheless manages to provide deep insights into consumers’ food choices—a crucial aspect for the agrifood industry and the formulation of food policies. This study aimed to analyze science mapping and synthesize research implications on the studies of consumers’ food choice motives using FCQ. In total, 169 FCQ-related journal articles were retrieved from the Scopus and Web of Science (WoS) databases for this study. The data were analyzed using a scoping review and bibliometric analysis (ScoRBA). The findings disclosed a positive trend in research on consumers’ food choice motives using FCQ. Notably, two seminal papers significantly influenced this field. Furthermore, specific research topics emerged and diversified over time, with recent themes encompassing consumer issues, consumer segments, research methods, and contextual factors. Recommendations for future research included: (1) conducting longitudinal studies to bridge the gap between food choice motives and dietary behaviors, with the incorporation of additional new recent factors; (2) longitudinal studies to explore nutrition, psychology, and health study groups in diverse cultural settings and more reliable research; (3) exploring FCQ research through a gender lens within varied cultural contexts, with an expansion of longitudinal research and more parameters; and (4) delving into FCQ research on adolescents, considering various potential influencing factors and utilizing data capable of elucidating causal relationships between variables.
Development of Underground Perimeter Intrusion Detection System

An underground passive security system based on minimal electric charge detection was developed and implemented in the real application field. The fixed length of the sensor cable is buried underground named a security zone. It is generated an alarm when an intruder goes into the security zone. A shielded telecommunication cable can be used for sensing the generated minimal charges by the external intrusion. If two different types of materials are rubbed with each other, minimal electric charges are generated, called the triboelectric effect. Minimal electric charges are generated between the cable shield and conductors when forces and impacts are applied to the underground buried cable. The control device detects and amplifies generated minimal charges due to the intruders on the sensor cable. The proposed system can be shown a reliable intrusion detection rate of up to 96%-97% when we have kept and considered all installation and environmental conditions.
An unexpected journey: Anuran decline research and the incidental elucidation of a new cryptic species endemic to the urban Northeast and Mid-Atlantic US

of the dissertation ii Acknowledgements iv Table of contents v List of tables vi List of figures x Introduction 1 Chapter 1: A new species of leopard frog (Anura: Ranidae) from the urban 7 northeastern US. Chapter 2: Cryptic diversity in Metropolis: confirmation of a new leopard 43 frog species (Anura: Ranidae) from New York City and surrounding Atlantic Coast regions. Chapter 3: A rapid assessment of post-hurricane impacts on the new leopard 119 frog, Rana (Lithobates) kauffeldi, in the New York City metropolitan region. Conclusions 160
Allergic Rhinitis: Tailoring Immunotherapy Through Innovative Diagnostics

Allergic rhinitis (AR) is a chronic ailment triggered by immunoglobulin E (IgE)-mediated reactions to allergens. Generally, AR is accompanied by asthma and conjunctivitis. The risk factors of AR include both inhalant and occupational allergens and genetic factors. Although AR is not a life-threatening condition, it poses a significant risk of morbidity and hampers work-related performance. Currently, the diagnosis of AR is based on clinical history and physical examination of the patients. Furthermore, several laboratory tests such as skin pricking test (SPT), nasal allergen challenge (NAC), and computed tomography (CT) are also recommended in some cases. Nasal cytology can aid in the differentiation of rhinitis because of allergy or infection. Apart from this, molecular diagnostic modalities such as basophil activation test (BAT) and Immune Solid-Phase Allergy Chip (ISAC) can also be employed for the confirmatory diagnosis of AR. Immunotherapy has demonstrated efficacy in the management of AR, with only mild side effects. With the advancement in the diagnostic realm of AR, personalized treatment approach has also gained significant popularity. Immunotherapy is gaining evidence on becoming a personalized treatment approach for the management of AR. This article provides a comprehensive overview, aiming to bridge the gap between evolving diagnostics and personalized therapeutic strategies for allergic rhinitis.
Studies on the Cultivation Techniques Characterized by Enhancing Source,Activating Sink and Improving Quality for Double-cropping Super Rice V. Theory and Technology

Based on the characteristics in cultivation of double-cropping super rice,a package of cultivation techniques of enhancing source,activating sink and improving grain quality(CTSSQ)was put forward,which is characterized by improving source and sink qualities under appropriate leaf area index(LAI)and sink capacity via suitable dense planting to achieve an early growth of lower tillers and a rapid LAI increase in early growing stages,alleviating decrease of chlorophyll content to strengthen functions of the source(leaves)and activity of the sink(grains)in late growing stages,resulting in an improvement in grain quality.The theoretic basis of CTSSQ was analyzed,and the CTSSQ for double-cropping super rice,which is a materialized-techniques-oriented technology including the use of ″a special seedling-strengthening agent(SSA)for super rice″,″a super rice specialized fertilizer(SSF)″ and ″a new super rice quality promoter(SRQP)″,was introduced in this article.It is found that CTSSQ is a super-high-yield cultivation system which is of high efficiency,labor-saving and easy to learn,accept and adopt by farmers.
Exploring the Psychological Nexus of Virtual and Augmented Reality on Physical Activity in Older Adults: A Rapid Review

With the global population of older adults projected to double to 2.1 billion by 2050, it becomes crucial to promote healthy aging to alleviate the associated disease burden. In this context, technology, particularly virtual reality (VR) and augmented reality (AR), has garnered attention for its potential to augment physical activity in older adults. These immersive technologies offer interactive and enjoyable exercise experiences, making physical activity more appealing. However, the effectiveness of these interventions is not solely attributed to technology itself but is deeply intertwined with psychological processes. This rapid review examines the effectiveness of VR and AR interventions in enhancing physical exercise among healthy older adults while exploring the role of psychological variables, including mood, self-efficacy, and motivation. The results of the study show that technology-enhanced physical activity interventions hold great promise but call attention to the need for a comprehensive understanding of psychological dynamics that will pave the way for more tailored and effective interventions. Future research endeavors should aim to bridge these gaps in knowledge to optimize the impact of technology on healthy aging.
Design and Experiment Investigation on Soft Grippers with Modular Variable Stiffness Structure

Soft grippers have good adaptability and flexibility for grasping irregular or fragile objects, and to further enhance their stiffness, soft grippers with variable stiffness have been developed. However, existing soft grippers with variable stiffness have the disadvantages of complex structure and poor interchangeability. Here, a soft gripper with modular variable stiffness is proposed that has flexible Velcro embedded in the bottom layer of the soft actuator and one side of the variable stiffness cavity respectively, and both the general and variable stiffness grasping modes are achieved by separation or combination. First of all, according to the neo-Hookean model and the assumption of constant curvature, a free bending model of the soft actuator is established and optimal structural parameters of the soft actuator are obtained by the Genetic Algorithm. Then, influence of the driving pressure on the soft actuator stiffness is investigated, and a mathematical model of the variable stiffness is established. Finally, correctness of the statics model and the stiffness model were verified by experiments. Experimental results indicate that the proposed soft gripper with modular variable stiffness structure has excellent adaptability and stability to different objects, outstanding load bearing capacity, and stiffness adjustment capability.
Bioaccumulation of some heavy metals in tilapia fish relevant to their concentration in water and sediment of Wadi Hanifah , Saudi Arabia

Concentrations of some heavy metals (Pb, Cd, Hg, Cu and Cr) were determined in water, sediment and tissues of tilapia fish collected from Wadi Hanifah during summer 2010. The concentrations of the heavy metal in water were within the international permissible level. Cu had the highest accumulating level in fish whilst Hg had the lowest. The transfer factors of all metals in fish from water were greater than those from sediments. This led to the conclusion that fish bioaccumulation with these metals was from water. Heavy metals under study in the edible parts of tilapia were within the safety permissible level for human use.
A study on the Assessment of Knowledge, Attitude and Practice towards Antibiotic Utilization among Pharmacy Students

Aim: To assess the knowledge, attitude and practice towards the antibiotics utilization among the pharmacy students. Materials and Methods: This was a prospective study conducted among the pharmacy students by using the KAP questionnaire which was circulated by means of Google form to various Pharmacy colleges located in Andhra Pradesh, India. Students from pharmacy colleges with both the gender of all age groups were included. Students who were studying the first and second years of B.Pharm & Pharm.D and students other than the pharmacy field were excluded from the study. Results: A total of 256 pharmacy students were participated in the study and among them 73 (28.5%) were found to be males and 183 (71.5%) were found to be females. Among the 256 study participants 90 (35.1%) were having good knowledge towards the antibiotics utilization, 88 (34.4%) were having moderate knowledge towards the antibiotic utilization and the remaining 78 (30.5%) were having poor knowledge towards antibiotic utilization. Most of the study participants were having good knowledge (35.1%) followed by moderate knowledge (34.4%). About 147 (57.4%) study participants thought that antibiotics should be prescribed only after culture and sensitivity report, 208 (81.2%) study participants thought that antibiotic resistance is a serious global health issue and 213 (83.2%) study participants thought that abuse of antibiotics has become the main cause leading to bacterial resistance. About 202 (78.9%) study participants used to consult a doctor before starting antibiotics, 196 (76.6%) study participants used to take the full course of antibiotics prescribed by a doctor and 157 (61.3%) study participants used to stop taking antibiotics when started feeling better. Conclusion: Pharmacy students should have good knowledge, attitude and practice towards the antibiotic utilization as they are directly or indirectly involving in the patient care where the rational usage of the antibiotics is mandatory to deal with the serious global health issue like the antibiotic resistance.
Algorithm for Analyzing the Microenvironment Surrounding Melanoma

Peritumoral areas or microenvironments surrounding melanoma are unexplored and partially understood, so that, in the following paper, an algorithm that predicts the trend of the melanoma progression is proposed. Additionally, in case of melanoma the peritumoral area is significantly correlated with the texture that belongs inside the skin lesion. The proposed algorithm analyses the region of interest (ROI) with Normalized 2-D cross-correlation (NCC) method and predicts the pattern in the peritumoral area which is most similar with the texture of the melanoma. An important step is the detection of the peritumoral area, in which case, the mathematical morphology techniques were proposed. The verifying of similarity between the samples cropped from inside the melanoma and peritumoral area with Structural Similarity Index (SSIM) was performed. The main advantage of the proposed algorithm is that it can be applied on different medical image types and tumors. The algorithm was tested on two datasets 7-Point and PH2, and two computes.
Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition

Hyperhomocysteinemia (HHcy) is recognized as an independent risk factor for various significant medical conditions, yet controversy persists around its assessment and management. The diagnosis of disorders afffecting homocysteine (Hcy) metabolism faces delays due to insufficient awareness of its clinical presentation and unique biochemical characteristics. In cases of arterial or venous thrombotic vascular events, particularly with other comorbidities, it is crucial to consider moderate to severe HHcy. A nutritional approach to HHcy management involves implementing dietary strategies and targeted supplementation, emphasizing key nutrients like vitamin B6, B12, and folate that are crucial for Hcy conversion. Adequate intake of these vitamins, along with betaine supplementation, supports Hcy remethylation. Lifestyle modifications, such as smoking cessation and regular physical activity, complement the nutritional approach to enhance Hcy metabolism. For individuals with HHcy, maintaining a plasma Hcy concentration below 50 μmol/L consistently is vital to lowering the risk of vascular events. Collaboration with healthcare professionals and dietitians is essential for developing personalized dietary plans addressing the specific needs and underlying health conditions. This integrated approach aims to optimize metabolic processes and reduce the associated health risks.
Characterization of Moringa oleifera Seed Oil for the Development of a Biopackage Applied to Maintain the Quality of Turkey Ham

Moringa oleifera has a high level of active chemicals that are useful in the food industry, and they have antibacterial and food preservation properties. The characterization of M. oleifera seed oil (MOS) may vary due to agronomic and environmental factors. Therefore, it was necessary to know the composition of lipids present in our oil extracted under pressing at 180 °C and thus determine if it is suitable to produce a biopackaging. Within the characterization of the oil, it was obtained that MOS presented high-quality fatty acids (71% oleic acid) with low values of acidity (0.71 mg KOH/g) and peroxide (1.74 meq O2/kg). Furthermore, MOS was not very sensitive to lipoperoxidation by tert-butyl hydroperoxide (tBuOOH) and its phenolic components, oleic acid and tocopherols, allowed MOS to present a recovery of 70% after 30 min of treatment. Subsequently, a biopackaging was developed using a multiple emulsion containing corn starch/carboxymethylcellulose/glycerol/MOS, which presented good mechanical properties (strength and flexibility), transparency, and a barrier that prevents the transfer of UV light by 30% and UV-C by 98%, as well as a flux with the atmosphere of 5.12 × 10−8 g/ m.s. Pa that prevents moisture loss and protects the turkey ham from O2. Hence, the turkey ham suffered less weight loss and less hardness due to its preservation in the biopackaging.
Community Engagement Research

The aim of this research-based community service is to provide creative space for youth and children in the Simpang Tiga village by applying the Community-Based Participatory Research approach. (CBPR). The activity focuses on the development of skills in the manufacture of canvas totebags using ecoprint techniques based on natural pigments from leaves around resident settlements. The dedication team delivered the material through a lecture approach as well as a question-and-answer session followed by a demonstration and practical production of the ecoprint totebag. The responses from the participants indicated a high level of enthusiasm, with the majority revealing that these activities add value to the use of their time. The expectation of the participants is that there will be continued activities on a periodic basis to produce products that are more diverse and beneficial to the community.