Miracle-dz/UniFAR-FTUs huggingface dataset:
New Progress on HVDC Technology Based on Voltage Source Converter

A novel high voltage DC transmission(HVDC) technique based on voltage sourced converter(VSC),fully-controlled power electronic devices and pulse width modulation(PWM) technology is introduced.The work principle and key technology of VSC based HVDC(VSC-HVDC) are presented in detail.The technical characteristics and application fields of VSC-HVDC are analyzed.The latest research and application status,especially the research trends of the first VSC-HVDC demonstration project for wind power grid integration in China,are described.It is shown that VSC-HVDC has extensive application prospect and is one of an important development direction for power transmission in future.
Virtual reality enhanced Dialectical behavioural therapy

ABSTRACT Virtual reality (VR) as a tool to build wellbeing for students with latent trauma is being examined in multiple contexts. The purpose of this study was to compare modalities of treatment, namely, VR-enhanced therapy, face-to-face therapy without VR and wait-list time-delayed control. Participants were 69 students selected from a high-needs urban school. Observations, researcher assessments and paper instrument scores, were analysed using a mixed model measure ANOVA. Results for each of the measures comparing standardised scores across the main effect of modality illustrates a statistically significant difference between virtual reality enhanced Dialectical Behaviour skills training and each of the other modalities. We suggest approaches using VR-enhanced DBT promote greater DBT skill acquisition. Highlights • VR-enhanced DBT shows more rapid skill development. • Students using VR-enhanced DBT illustrate more prosocial behaviours. • VR contributes to positive interactions at the classroom level. • VR-enhanced DBT shows results after six weeks of implementation with supports from teachers.
Diversity of Shallow-Water Species in Prawn Trawling: A Case Study of Malindi–Ungwana Bay, Kenya

Bottom trawling is a common fishing method that targets bottom-dwelling fisheries resources. It is non-selective and large amounts of by-catch are discarded, raising serious sustainability and ecosystem conservation concerns. In this study, a shallow-water bottom-trawl fishery was evaluated using logbook catch data between 2011 and 2019 and the species composition data collected by fisheries observers between 2016 and 2019. The logbook data showed a twenty-fold increase in the annual catches with a ten-fold increase in fishing effort and an increase in the proportion of retained catch from 2011 to 2019. The observer data showed that for prawn, the by-catch ratio ranged from 1:3 to 1:9 during the four years. Multivariate analysis revealed significant differences between the compositions of retained and discarded catches mainly attributed to Pellona ditchela, Nematopalaemontenuipes, and Secutor insidiator. There was no significant decline in species diversity and the trophic level of the catches over the 4-year observer period indicating no marked impact of trawling on the stock at the current level of fishing effort. This study provides baseline information on the prawn trawl fishery against which the performance of the management regulations may be evaluated towards the Ecosystem Approach to Fisheries management.
Added Fructose in Non-Alcoholic Fatty Liver Disease and in Metabolic Syndrome: A Narrative Review

Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease and it is considered the hepatic manifestation of metabolic syndrome (MetS). Diet represents the key element in NAFLD and MetS treatment, but some nutrients could play a role in their pathophysiology. Among these, fructose added to foods via high fructose corn syrup (HFCS) and sucrose might participate in NAFLD and MetS onset and progression. Fructose induces de novo lipogenesis (DNL), endoplasmic reticulum stress and liver inflammation, promoting insulin resistance and dyslipidemia. Fructose also reduces fatty acids oxidation through the overproduction of malonyl CoA, favoring steatosis. Furthermore, recent studies suggest changes in intestinal permeability associated with fructose consumption that contribute to the risk of NAFLD and MetS. Finally, alterations in the hunger–satiety mechanism and in the synthesis of uric acid link the fructose intake to weight gain and hypertension, respectively. However, further studies are needed to better evaluate the causal relationship between fructose and metabolic diseases and to develop new therapeutic and preventive strategies against NAFLD and MetS.
Assessment of Urban Mobility via a Pressure-State-Response (PSR) Model with the IVIF-AHP and FCE Methods: A Case Study of Beijing, China

Urban transportation issues continue to emerge and evolve as a result of rapid urbanization, and the systematic and scientific assessment of urban mobility is becoming increasingly essential. In this work, a Pressure-State-Response (PSR) model with 25 indicators was established to reflect the status of urban mobility. Then, the importance of indicators was determined with the interval-valued intuitionistic fuzzy analytic hierarchy process (IVIF-AHP) method, and the fuzzy comprehensive evaluation (FCE) method was applied to assess the overall status of urban mobility. The validity of the proposed model was demonstrated using the mobility system of Beijing as a case study, and the pressure, state, and response scores were calculated. The proposed assessment model can help to improve urban transportation monitoring and can also provide a scientific foundation for future urban transportation policymaking, planning, and traffic management, thereby further ensuring the sustainable development of urban transportation systems.
Overcoming Multidrug Resistance of Antibiotics via Nanodelivery Systems

Antibiotic resistance has become a threat to microbial therapies nowadays. The conventional approaches possess several limitations to combat microbial infections. Therefore, to overcome such complications, novel drug delivery systems have gained pharmaceutical scientists’ interest. Significant findings have validated the effectiveness of novel drug delivery systems such as polymeric nanoparticles, liposomes, metallic nanoparticles, dendrimers, and lipid-based nanoparticles against severe microbial infections and combating antimicrobial resistance. This review article comprises the specific mechanism of antibiotic resistance development in bacteria. In addition, the manuscript incorporated the advanced nanotechnological approaches with their mechanisms, including interaction with the bacterial cell wall, inhibition of biofilm formations, activation of innate and adaptive host immune response, generation of reactive oxygen species, and induction of intracellular effect to fight against antibiotic resistance. A section of this article demonstrated the findings related to the development of delivery systems. Lastly, the role of microfluidics in fighting antimicrobial resistance has been discussed. Overall, this review article is an amalgamation of various strategies to study the role of novel approaches and their mechanism to fight against the resistance developed to the antimicrobial therapies.
The complete mitochondrial genomes of Ephemera serica (Ephemeroptera: Ephemeridae) and phylogenetic analysis

Abstract In the present research, the mitochondrial genome of Ephemera serica was sequenced through next generation sequencing methods and its phylogenetic position in Ephemeroptera was analyzed. Total mitochondrial genome is 15,004 bp in length, and contains 13 protein coding genes, two ribosomal RNA genes, and 22 transfer RNA genes. Mitogenomic phylogeny trees were constructed including 45 species from 13 families. The results show that E. serica is closely related to E. rufomaculata.
Machine Learning Approaches to Identify Discriminative Signatures of Volatile Organic Compounds (VOCs) from Bacteria and Fungi Using SPME-DART-MS

Point-of-care screening tools are essential to expedite patient care and decrease reliance on slow diagnostic tools (e.g., microbial cultures) to identify pathogens and their associated antibiotic resistance. Analysis of volatile organic compounds (VOC) emitted from biological media has seen increased attention in recent years as a potential non-invasive diagnostic procedure. This work explores the use of solid phase micro-extraction (SPME) and ambient plasma ionization mass spectrometry (MS) to rapidly acquire VOC signatures of bacteria and fungi. The MS spectrum of each pathogen goes through a preprocessing and feature extraction pipeline. Various supervised and unsupervised machine learning (ML) classification algorithms are trained and evaluated on the extracted feature set. These are able to classify the type of pathogen as bacteria or fungi with high accuracy, while marked progress is also made in identifying specific strains of bacteria. This study presents a new approach for the identification of pathogens from VOC signatures collected using SPME and ambient ionization MS by training classifiers on just a few samples of data. This ambient plasma ionization and ML approach is robust, rapid, precise, and can potentially be used as a non-invasive clinical diagnostic tool for point-of-care applications.
Population Structure of a Worldwide Collection of Tropical Japonica Rice Indicates Limited Geographic Differentiation and Shows Promising Genetic Variability Associated with New Plant Type

Abating the approaching yield plateau in rice requires taking advantage of potential technologies that requires knowledge on genetic diversity. Hybrid breeding, particularly in indica rice, requires the recruitment of large genetic variability from outside because the available genetic diversity of the cultivated pool has already been utilized to a great extent. In this study, we examined an assembly of 200 tropical japonica lines collected worldwide for population genetic structure and variability in yield-associated traits. Tested along with 30 indica and six wild rice lines belonging to India, the tropical japonica lines indicated great phenotypic variability, particularly related to new plant type (NPT) phenology, and formed six clusters. Furthermore, a marker-based characterization using a universal diversity marker panel classified the genotype assembly into four clusters, of which three encompassed tropical japonica lines, while the last cluster included mostly indica lines. The population structure of the panel also revealed a similar pattern, with tropical japonica lines forming three subpopulations. Remarkable variation in the allelic distribution was observed between the subpopulations. Superimposing the geographical sources of the genotypes over the population structure did not reveal any pattern. The genotypes sourced closer to the center of origin of rice showed relatively little diversity compared with the ones obtained from other parts of the world, suggesting migration from a common region of origin. The tropical japonica lines can be a great source of parental diversification for hybrid development after confirming the presence of widely compatible genes.
GC-MS Metabolite and Transcriptome Analyses Reveal the Differences of Volatile Synthesis and Gene Expression Profiling between Two Apple Varieties

Aroma is a key quality attribute of apples, making major contributions to commercial value and consumer choice. However, the mechanism underlying molecular regulation of aroma formation genes and transcription factors remains poorly understood in apples. Here, we investigated the aroma volatile profiles of two apple varieties with distinctive flavors using headspace solid-phase microextraction (HS-SPME) combined with gas chromatography–mass spectrometry (GC-MS). A total of 35 volatile compounds were identified in Granny Smith and Jonagold apples. Aldehydes were the most abundant volatiles contributing to the aroma in Granny Smith apple while esters were the dominant volatile compounds in Jonagold apple. In order to know more about the expression levels of aroma-related genes involved in the metabolic pathways, transcriptome sequencing of these two different apple varieties was conducted utilizing the Illumina platform. In total, 94 differentially expressed genes (DEGs) were found in the fatty acid metabolism, amino acid metabolism, the mevalonate pathway and phenylpropanoid pathway. Furthermore, compared to the Granny Smith apple, the expression of multiple genes and transcription factors were upregulated in the Jonagold apple, which might play important roles in the synthesis of aroma volatile compounds. Our study contributes toward better understanding on the molecular mechanism of aroma synthesis in apples and provides a valuable reference for metabolic engineering and flavor improvement in the future.
Synthesis and Investigation of Flavanone Derivatives as Potential New Anti-Inflammatory Agents

Flavonoids are polyphenols with broad known pharmacological properties. A series of 2,3-dihydroflavanone derivatives were thus synthesized and investigated for their anti-inflammatory activities. The target flavanones were prepared through cyclization of 2′-hydroxychalcone derivatives, the later obtained by Claisen–Schmidt condensation. Since nitric oxide (NO) represents an important inflammatory mediator, the effects of various flavanones on the NO production in the LPS-induced RAW 264.7 macrophage were assessed in vitro using the Griess test. The most active compounds were flavanone (4G), 2′-carboxy-5,7-dimethoxy-flavanone (4F), 4′-bromo-5,7-dimethoxy-flavanone (4D), and 2′-carboxyflavanone (4J), with IC50 values of 0.603, 0.906, 1.030, and 1.830 µg/mL, respectively. In comparison, pinocembrin achieved an IC50 value of 203.60 µg/mL. Thus, the derivatives synthesized in this work had a higher NO inhibition capacity compared to pinocembrin, demonstrating the importance of pharmacomodulation to improve the biological potential of natural molecules. SARs suggested that the use of a carboxyl-group in the meta-position of the B-ring increases biological activity, whereas compounds carrying halogen substituents in the para-position were less active. The addition of methoxy-groups in the meta-position of the A-ring somewhat decreased the activity. This study successfully identified new bioactive flavanones as promising candidates for the development of new anti-inflammatory agents.
Ultrasound Viscoelastic Properties of Biomass Polysaccharide Hydrogels as Evaluated by Rheometer Equipped with Sono-Device

A viscoelastic rheometer was equipped with a sono-device and a water bath to enable measurement of storage moduli G′ and loss moduli G″ of biomass polysaccharide hydrogels such as Kanten agarose, κ-carrageenan, and konjac glucomannan under ultrasound (US) exposure. The action of low power of 43 kHz US on their hydrogels significantly decreased G′ of Kanten agarose and carrageenan after a few seconds of US exposure 0.1% strain. When US with 20 W output power was exposed under mechanical strain at 0.1%, lower values were obtained cyclically for 3 min US intervals. The values then reverted to the original moduli values when US was stopped in cases of Kanten agarose and carrageenan hydrogels. As G″ values were increased during US operation, the anhydro-L-galactose segments in their hydrogels were unable to relax the external US forces within the gel sufficiently, thereby leading to gel structure collapse at a higher strain percentage. These results suggest that US exposure induced deformational change in the hydrogel structure formed by hydrogen-bonded cross-links. However, US deformation was less in the case of deacetylated cross-linkage in konjac glucomannan hydrogel.
COMPACT NEGATIVE-PERMITTIVITY MICROSTRIP PATCH ANTENNA FOR END-FIRE RADIATION

We propose a compact microstrip patch antenna that uses a negative permittivity substrate to achieve an end-fire radiation pattern. The antenna is designed to operate at X-band frequencies with a patch footprint of 0. 9λ × 0. 05λ and a thickness of λ/20. We show that loading a narrow patch with a negative permittivity substrate introduces an effective shunt inductance that resonates with the strong fringing capacitance of the patch. At resonance, the electric field is vertically polarized and approximately uniform across the patch, producing transverse nulls that improve the directivity of the antenna. The negative permittivity substrate is implemented using a thin-wire effective medium with four vias spread across the patch. The antenna is matched to 50Ω using a quarter-wavelength transformer. The fabricated antenna operates at 10.8GHz with a peak return loss of 30 dB and a bidirectional directivity of 10.7 dBi. The antenna has a 10-dB impedance bandwidth of 3.8% and radiates with a simulated efficiency of 93%.
Performance Evaluation of Phase Change Materials to Reduce the Cooling Load of Buildings in a Tropical Climate

Tropical region such as Darwin has similar weather patterns throughout the year, thus creating higher energy demands in residential buildings. Typically, buildings consume about 40 per cent of the total energy consumption for indoor heating and cooling. Therefore, building envelopes are linked with design strategies such as the use of thermal energy storage and phase change materials (PCM) to minimize this energy consumption by storing a large amount of thermal energy. Primarily, PCMs are targeted by researchers for use in different components of buildings for thermal efficiency; thus, this study aimed to provide a suitable PCM to optimize indoor thermal comfort and minimize the cooling loads of residential buildings in tropical climates through simulation of a tropical climate building and provide optimum thickness for the selected material. Microencapsulated PCM mixed with gypsum in wallboards were used to reduce the cooling load of a building located in Darwin. The cooling load of the building was calculated using Revit software. A comparison of the cooling load of the building was carried out using PCM-incorporated wallboards of thicknesses of 0 cm, 1 cm and 2 cm in Energy Plus software. The total cooling load decreased by 1.1% when the 1-centimetre-thickness was applied to the wall, whereas a 1.5% reduction was obtained when a 2-centimetre-thick PCM layer was applied. Furthermore, the reduced cooling loads due to impregnation of the PCM-based gypsum wallboard gave reduced energy consumption. Ultimately, the 2-centimetre-thickness PCM-based gypsum wallboard gave a maximum reduction in cooling load with a 7.6% reduction in total site energy and 4.76% energy saving in USD/m2/year.
Pedestrian detection method of vision based on HOG features

Pedestrian detection is intensively investigated and becoming a hot topic in the field of computer vision.By making use of monocular vision detector as the main mean of catching outside environmental information,a pedestrian detection system including segmenting of regions of interests(RoIs)and recognizing detection system is built.According to the particular characteristic of pedestrian,based on pedestrian segmenting method grounding on vertical edge and the symmetry property of it,and the pedestrian is accurately located and segmented from the video image.In the recognition process,HOG feature extraction method is produced to extract pedestrian features and a linear support vector machine(SVM)is used for pedestrian recognition.A large number of tests at different kinds of weather and scenes are carried out.Experimental results show that the pedestrian detection algorithm has effective performance.
Kinematic model of the parallel convergence method in space

In this article, the implementation of the method of parallel convergence in space in a computer mathematics system is considered and discussed. In this method, the pursuer’s velocity vector is directed arbitrarily. The pursuer’s trajectory gradually approaches movement in the plane formed by the line connecting the initial positions of the pursuer and the target, and the velocity vector. In this task, the target moves uniformly and rectilinearly. The pursuer moves evenly. The points of the pursuer’s trajectory are calculated sequentially. They are being the result of the intersection of the plane containing the line of sight, sphere and cone. As we approach the plane where the target is moving, the algorithm for calculating the trajectory points changes. Now the point of the pursuer’s trajectory is the result of the intersection of the sphere, the plane of movement of the target and the plane containing the line of sight.
COVID-19 and Seasonal Influenza Vaccination: Cross-Protection, Co-Administration, Combination Vaccines, and Hesitancy

SARS-CoV-2 and influenza are the main respiratory viruses for which effective vaccines are currently available. Strategies in which COVID-19 and influenza vaccines are administered simultaneously or combined into a single preparation are advantageous and may increase vaccination uptake. Here, we comprehensively review the available evidence on COVID-19/influenza vaccine co-administration and combination vaccine candidates from the standpoints of safety, immunogenicity, efficacy, policy and public acceptance. While several observational studies have shown that the trained immunity induced by influenza vaccines can protect against some COVID-19-related endpoints, it is not yet understood whether co-administration or combination vaccines can exert additive effects on relevant outcomes. In randomized controlled trials, co-administration has proved safe, with a reactogenicity profile similar to that of either vaccine administered alone. From the immunogenicity standpoint, the immune response towards four influenza strains and the SARS-CoV-2 spike protein in co-administration groups is generally non-inferior to that seen in groups receiving either vaccine alone. Several public health authorities have advocated co-administration. Different combination vaccine candidates are in (pre)-clinical development. The hesitancy towards vaccine co-administration or combination vaccines is a multifaceted phenomenon and may be higher than the acceptance of either vaccine administered separately. Public health implications are discussed.