Miracle-dz/UniFAR-FTUs huggingface dataset:
Radiation Synthesis of Methacrylic Acid/Poly (2-Ethyl-2-Oxazoline) Copolymer Hydrogel for Colon-Specific Drug Targeting Delivery System

PH-sensitive hydrogels composed of Methacrylic acid and Poly (2-ethyl-2-oxazoline) (MAAc/PEOz) were prepared by means of γ-radiation induced graft copolymerization and crosslinking. The prepa ration parameters such as feed solution composition and concentration and irradiation dose were optimized. The effect of pH on the equilibrium of swelling for the prepared hydrogels was examined. Studying the dif fusion’s parameters and coefficient as a function of the pH values for the surrounding solution showed obvious changes in the swelling parameters as a result of changing the surrounding solution pH values. In order to es timate the ability of the prepared copolymer to be used as a colon-specific drug carrier, the release of indomethacin was monitored as a function of time at pH 3 and pH 7. The observed results show the capability of the prepared hydrogel to protect the contained model drug at buffer solution of pH 1 and start releasing the drug as soon as the hydrogel transferred to buffer solution of pH 7. Such data would recommend the prepared hy drogel as a promising candidate for colon specific drug delivery system. ABSTRACT Broccoli Leaves Low Caloric Cake, Replacement, Total Phenolic Compounds, Antioxidant, Physical Properties, Sensory Properties. The present study aims to improve the antioxidant and antimicrobial properties of cake and produce low calorie cake through substitution of wheat flour (WF) by irradiated broccoli ( Brassica oleracea L.var italica ) powder. In this study broccoli heads powder and broccoli leaves pow der were gamma irradiated at dose levels of 0, 3, 5 and 7 kGy. Results showed that ethanolic (70%) extract of irradiated broccoli heads powder (IBHP) and irradiated broccoli leaves powder (IBLP) at a dose level of 5 kGy had higher total phenolic compounds (TPC) and antioxidant activ ity (AOA) compared to control and other doses. Thus, IBHP and IBLP at dose level of 5 kGy were selected for fortification of cake. IBHP was used to substitute (0, 1.5, 3, and 4.5 %) of WF in making cake, as well, replacement of WF (0, 1, 2 and 3%) by IBLP. The results showed that the cake processed from IBHP and IBLP had pronounced improvement (%) in its chemical composition (protein, lipids,
Performance evaluation, Optimization and exergy analysis of a high temperature co‐electrolysis power to gas process using Aspen Plus®‐a model based study

In this paper, a high temperature coelectrolysis power to gas (LTE PtG) setup was developed that was fed a stereotypical feed in CO2 one could acquire from carbon capture and sequestration (CCS) retrofit. The electrolyzer was fed an equimolar 10 kmol/s feed in water and CO2 and the electrolyzer product was composed of 38.80 mole% CO2, 30.96 mole% CO, and 30.24 mole% H2 for a syngas conversion of 43.8%. The product from the methanation unit was only composed of 21.38 mole% CH4, with the rest (76.53 mole%) being predominantly CO2. The methanation unit was composed of only one Sabatier reactor operating at 313°C, which had 90% of its product recycled back to the front end of the unit. The electrolyzer was found to have a LHV efficiency of 31.49%, and the entire HTCE PtG process was found to have an efficiency of 74.31% with methane storage and 76.49% without methane storage. A novel adaptation was developed on previous work on the exergy analysis for flow‐sheet simulators which can be used for cyclic and noncyclic processes. The procedure was determined to be accurate, with irreversibilities determined across all the major subunits found to equal the irreversibility around the processes a whole. The electrolyzer was found to be responsible for the majority of the irreversibility within the setup, and this was attributed to the fact that water electrolysis is a very energy intensive process. The exergy efficiency of the electrolyzer was found to be 87.07% and that of the entire LTE PtG processes was found to be 84% with methane storage, and 87% without methane storage. In the end, it was determined that HTCE is unsuitable for the production of methane via retrofit with a methanation unit, and that it would be better suited for the production of liquid hydrocarbon fuels with much higher molecular carbon to hydrogen ratios.
Adaptive bridge estimator for Cox model with a diverging number of parameters

Abstract This article considers the adaptive bridge estimator for Cox proportional hazards model with a diverging number of parameters. Specifically, we assume that the number of covariates of the Cox model is not fixed, and use the adaptive bridge penalty method to select variables and estimate the parameters of the Cox model. We show that under some weak regularity conditions, our proposed method has oracle properties and can select non-zero coefficients with a probability converging to 1. We also present an algorithm based on the Minorization-Maximization method to solve the adaptive bridge estimation. In addition, simulation studies show that the proposed method is effective and the well-known primary biliary cirrhosis data is provided to illustrate the application of the proposed method in survival problems.
Evidence-Based Educational Innovation Model Linked to Digital Information Competence in the Framework of Education 4.0

Education 4.0 promotes visualizing how teachers’ traditional digital competencies adopt innovative practices. The present research analyzes the relationship between the perceived digital information competencies (DICs) of university teachers and the implementation of evidence-based, innovative actions (EBEI) in a model that supports innovative practices. The research method applied was the mixed method. In the quantitative phase, the final sample consisted of 271 teachers. The ad hoc digital competency-open educational resource scale (DC-OER) was applied to measure their perception of DIC. In the qualitative phase, 15 teachers were interviewed. The results showed (a) a close relationship between the fulfillment of EBEI and the support of DIC; (b) in quantitative results, in most cases, the means are close to the central value 3, and the standard deviation is close to 1, which indicates higher DIC; (c) the qualitative results indicate that teachers search, select, evaluate information, and produce new knowledge; and (d) the theoretical model of EBEI links DIC to the formation of digital citizenship. The data can be of value to the academic community in relevant environments within the framework of Education 4.0. As a future line of research, we envision analyzing the perceived digital competencies of teachers versus their effective behavior.
Detachment stress mediated bioenergetic switch of malignant melanoma cells into anti-Warburg phenotype

One of the biological features of cancer cells is their aerobic glycolysis by extensive glucose fermentation to harvest energy, so called Warburg effect. Melanoma is one of the most aggressive human cancers with poor prognosis and high mortality for its high metastatic ability. During the metastatic process, the metastatic tumor cells should survive under detachment stress. However, whether the detachment stress could affect the tumor phenotype is worthy to investigate. We had established the cell model of human melanoma cells under detachment stress, which mimicked circulating melanoma. It had been demonstrated that the detachment stress altered melanoma cell activities, malignancy, and drug sensitivity. In this study, we found that adherent melanoma cells were more sensitive to glucose depletion. Gene expression profiling altered expressions of transporters associated with glucose metabolism. In addition, detachment stress reduced lactate secretion owing to the reduced MCT4 and GLUT1 expressions, the altered glycolytic and respiratory capacities, and the increased superoxide production. Detachment stress also increases the sensitivity of melanoma cells toward the blockade of electron transport chains. Investigation of the change in glucose metabolism of melanoma cells under detachment stress would be critical to provide a novel molecular mechanism to develop potential therapeutics.
Design and control of mechatronic systems with pneumatic and hydraulic drive

This paper presents four handmade laboratory systems with pneumatic and hydraulic drive. The article first presents an example of a pneumatic motor speed control using a proportional directional control valve. Then the paper presents the design and control of a test device with pneumatic drive for determining the dynamic strength of materials, on which the fracture mechanics of materials due to the action of dynamic stress can be experimentally demonstrated and the resistance of materials to cyclic stress can be analyzed. The article then describes the design, construction and control of a pneumatically driven system for sorting products marked with a bar code using a vision system. The final section of the article describes an experimental setup for precise position control of a hydraulic cylinder using 2/2 cartridge valves, which can clearly demonstrate the application possibilities of these valves in industrial plants and mobile systems.
System of antioxidant protection of the body of piglets under the action of feed additive “Butaselmevit-plus”

The aim of the study was to investigate the effect of the feed additive “Butaselmevit-plus” on the state of the antioxidant defense system of piglets during weaning. The experiments were conducted on the basis of the LTD “KOSHET” Mukachevo district of Zakarpattia region. Two groups of piglets were formed – control and experimental, in the amount of 10 individuals in each group, selected on the principle of analogs – age, breed and body weight. Animals were fed according to the norms for this age of pigs. On the 28th day of life, the piglets were weaned from the sow and regrouped from different nests for further maintenance during fattening and rearing with a change in the structure of the diet, which served as technological stress for the animal's body. Piglets of the experimental group, from 21 to 40 days of age, were additionally fed the feed additive “Butaselmevit-plus” at a dose of 100 mg/kg body weight per day. The material for the study was blood, which was taken in the morning before feeding the animals by puncture of the cranial vena cava for 20 days of life (the period before weaning), for 25 days of life (the period before weaning), for 30 days of life (2 days after weaning), for 35 days of life (7 days after weaning), 40 days of life (12 days after weaning). It is proved that feeding piglets feed additive “Butaselmevit-plus” enhanced the antioxidant status of piglets after weaning. It was found that under conditions of technological stress, the use of feed additive “Butaselmevit-plus” in the amount of 100 mg/kg body weight per day improves the antioxidant defense of the body, as evidenced by an increase in blood 35-day-old piglets superoxide dismutase activity by 26.7 % (P < 0.001), catalase – by 39.5 % (P < 0.001), glutathione peroxidase – by 51.7 % (P < 0.05), glutathione reductase – by 52.9 % (P < 0.05), the content of reduced glutathione – at 58.3 % (P < 0.001). These results confirm the effectiveness of the use of milk thistle, methionine, selenium, and vitamins A, E, and D3 in the feed additive “Butaselmevit-plus” to piglets in the period before and after weaning to activate the protective systems of their body.
EviChain: A scalable blockchain for accountable intelligent surveillance systems

Smart cameras, as typical IoT devices, are widely adopted to provide surveillance on individuals, homes, and the environment. The unavoidably captured sensitive visuals via these cameras may raise significant security concerns, while the prevalent software defects and authentication misconfiguration issues aggravate the vulnerability of such devices. However, traditional cryptography techniques are inadequate to provide full protection of these devices due to the large computation overhead. In this context, realizing accountability for these surveillance systems shall be the last line of defense in the presence of fast‐evolving and high‐influential threats. We propose EviChain, a scalable blockchain‐based solution to trace the operations on intelligent surveillance cameras and reserve the evidence for any misuse in tamper‐proofing manipulation records. Building a blockchain over the distributed cameras is challenging due to the limited capacity of on‐board memory. To tackle this challenge, we design a cooperative mechanism that enables cameras to adaptively join in groups and share storage for recording blocks. In addition, we present a computation efficiency and delay‐aware block generation strategy to reduce the cost of the consensus process. We perform extensive simulations to validate the superior performance of EviChain over other baselines, for example, Practical Byzantine Fault Tolerance (PBFT).
Analytical strategies for chemical exposomics: exploring limits and feasibility

Tackling the challenges of chemical exposomics will require the implementation of diverse analytical strategies and technological advancements. Herein, high-resolution mass spectrometry-based methods applied in current chemical exposome studies have been surveyed and are shown to be limited. Notably, liquid chromatography separations almost exclusively employ reversed-phase C18 columns using water-methanol gradients with formic acid additive, whilst gas chromatography is underexploited in the field at this stage. A systematic evaluation of strategies applied in related disciplines (i.e. metabolomics, proteomics, multi-residue trace analysis) was undertaken to provide practical guidance for the development of chemical exposomics. The approaches were assessed on the basis of their costs (i.e. capital expenditure, overhead and maintenance fees, expertise required, consumables) and potential benefits (i.e. improvements to sensitivity, coverage, reproducibility, throughput, ease of use) to prioritize those with promise for chemical exposomics application. Alongside a need for technological investments (e.g. advanced hardware updates), numerous low cost strategies showed high potential benefits (e.g. different column phases, enhanced sample fractionation) and are feasible for rapid adoption.
Elevated Vertical-Flow Constructed Wetlands for Light Greywater Treatment

Integrated planning of urban blue–green infrastructures is crucial to strengthen urban environmental quality and mitigate negative climate change-associated effects. It implies, however, increased water demand for irrigation, wherefore greywater (wastewater excluding wastewater from toilets and urinals) can be used, yet it requires handling for safe reuse. One treatment option is the use of constructed wetlands (CW), which have thus far not been broadly applied in inner-city districts due to large area requirements. This work investigates a novel bipartite container-based vertical-flow constructed wetland (VFCW) for the treatment of light greywater (from showers and hand wash basins) and its use as irrigation water for urban facade greenery. The VFCW consists of two compartments with 2.5 m2 filter area each, filled with 75 cm zeolite-containing lava sand (0–4 mm) and 75 cm Rhine sand (0–2 mm), respectively. In short, screening has proven to be well suitable for coarse solids removal, so there is no further need to settle light greywater, which reduces overall treatment area and benefits urban application. Treated greywater complied with irrigation standards at all times, yet mixing with rainwater can help reduce salt contents, if applicable. The modular/elevated lava sand VFCW exhibited extensive nitrification, even at extremely low water temperatures, as well as mean effluent concentrations of 6.3 mg/L COD and <0.05 mg/L Ptot, which makes it a very promising treatment option for greywater. All in all, the modular/elevated design promotes urban application of VFCW as a multifunctional blue–green system that can help increase urban resilience.
The drivers and health risks of the unexpected surface ozone enhancements over the Sichuan basin, China in 2020

Abstract. After a continuous increase in surface ozone (O3) level from 2013 to 2019, the overall summertime O3 concentration across China showed a significant reduction in 2020. In contrast to this overall reduction in surface O3 across China, unexpected surface O3 enhancements of 10.2 ± 0.8 ppbv (23.4 %) were observed in May–June 2020 vs. 2019 over the Sichuan basin (SCB), China. In this study, we use high resolution nested-grid GEOS-Chem simulation, the eXtreme Gradient Boosting (XGBoost) machine learning method and the exposure−response relationship to determine the drivers and evaluate the health risks of the unexpected surface O3 enhancements. We first use the XGBoost machine learning method to correct the GEOS-Chem model-to-measurement O3 discrepancy over the SCB. The relative contributions of meteorology and anthropogenic emissions changes to the unexpected surface O3 enhancements are then quantified with the combination of GEOS-Chem and XGBoost models. In order to assess the health risks caused by the unexpected O3 enhancements over the SCB, total premature death mortalities are estimated. The results show that changes in anthropogenic emissions caused 0.9 ± 0.1 ppbv of O3 reduction and changes in meteorology caused 11.1 ± 0.7 ppbv of O3 increase in May–June 2020 vs. 2019. The meteorology-induced surface O3 increase is mainly attributed to significant increases in temperature and downward potential vorticity, and decreases in precipitation, specific humidity and cloud fractions over the SCB and surrounding regions in May–June 2020 vs. 2019. These changes in meteorology combined with the complex basin effect enhance downward transport of O3 from upper troposphere, enhance biogenic emissions of volatile organic compounds (VOCs) and nitrogen oxides (NOx), speed up O3 chemical production, and inhabit the ventilation of O3 and its precursors, and therefore account for the surface O3 enhancements over the SCB. The total premature mortality due to the unexpected surface O3 enhancements over the SCB has increased by 89.8 % in May–June 2020 vs. 2019.
Preventing Intimate Partner Homicide: The Long Road Ahead

Intimate partner homicide (IPH) consists primarily of men killing women in the context of intimate partner violence. Researchers have described and identified risk factors associated with IPH; additional comprehensive data collection is needed to better understand IPH risk and to develop risk-informed prevention. Due to structural racism, available interventions within the criminal legal and social service systems may be eschewed by those—such as Black women—who are at the highest risk. Anti-racist research, practice, and policy are key to reducing IPH. Gender and racial equity, combined with fostering relational health leads, ultimately, down the long road to IPH prevention.
Unenhanced computed tomography for non-invasive diagnosis of hepatic steatosis with low tube potential protocol.

Background Lowering kVp affects the image contrast and computed tomography (CT) attenuation values of low kVp CT is different from those of conventional 120-kVp scans. The purpose of this study is to determine the diagnostic performance and to establish the reference range of low-kVp unenhanced CT for the assessment of hepatic steatosis in liver transplantation donors using magnetic resonance (MR) spectroscopy as a reference standard. Methods This retrospective study included 165 potential donors (male:female =114:51, 36.5±12.0 years old) who underwent 100-kVp single-slice unenhanced CT scan and MR spectroscopy. The difference between hepatic and splenic attenuation (CTL-S) and liver-to-spleen attenuation ratio (CTL/S) were calculated. Reference standard was the fat signal fraction measured by MR spectroscopy. Limits of agreement between CT measurements and the reference standard were calculated. Areas under receiver operating characteristic curves (AUROCs) of CTL-S and CTL/S were compared for the diagnosis of moderate to severe steatosis. Cut-off values of CTL-S and CTL/S that provided a balance between sensitivity and specificity and the highest specificity using the lower limit of the reference range were calculated. Results Eighty-seven subjects had a non-steatotic liver. Sixty-one subjects had mild steatosis and 17 subjects had moderate to severe steatosis based on MR spectroscopy. CTL-S and CTL/S values were negatively correlated with the fat signal fraction (P<0.001) and limits of agreement were -8.4% to 8.4% for CTL-S and -9.6% to 9.6% for CTL/S. AUROCs of CTL-S and CTL/S for diagnosing moderate to severe steatosis were 0.956 and 0.957, respectively. Cut-off values of CTL-S and CTL/S for diagnosis of moderate to severe steatosis by the Youden index were -0.5 HU for CTL-S and 0.99 for CTL/S. Reference ranges of non-steatotic liver were -6.90 to 31.40 HU for CTL-S and 0.89 to 1.77 for CTL/S. Using -6.9 HU for CTL-S and 0.89 for CTL/S as cut-off values, the sensitivity and specificity for diagnosing moderate to severe steatosis were 70.59% and 90.54% (CTL-S) and 76.47% and 90.54% (CTL/S), respectively. Conclusions Measurements from a low-kVp unenhanced CT scan were negatively correlated with the degree of hepatic steatosis. Low-kVp unenhanced CT is a robust technique with reduced radiation exposure for diagnosing moderate to severe hepatic steatosis.
Prediction of carcass composition and meat and fat quality using sensing technologies: A review

Consumer demand for high-quality healthy food is increasing, thus meat processors require the means toassess these rapidly, accurately, and inexpensively. Traditional methods forquality assessments are time-consuming, expensive, invasive, and have potentialto negatively impact the environment. Consequently, emphasis has been put onfinding non-destructive, fast, and accurate technologies for productcomposition and quality evaluation. Research in this area is advancing rapidlythrough recent developments in the areas of portability, accuracy, and machinelearning. The present review, therefore, critically evaluates and summarizes developmentsof popular non-invasive technologies (i.e., from imaging to spectroscopicsensing technologies) for estimating beef, pork, and lamb composition andquality, which will hopefully assist in the implementation of thesetechnologies for rapid evaluation/real-timegrading of livestock products in the nearfuture.