Miracle-dz/UniFAR-FTUs huggingface dataset:
Antioxidant, antidiabetic and anticancer effects of persimmon leave extracts in vitro

This study aims evaluate the antioxidant, antidiabetic and anticancer effects of persim-mon leave extracts (PLEs). The results showed that all extracts had high amounts of phenolic and flavonoids components, the aqueous hot and cold extract exhibited the highest antioxidant activity determined by two methods (DPPH, ABTS), Vit. C and free sugar fractions determined by HPLC than ethanolic ex. Also, these extracts (aqueous hot and old) had high inhibition % of α - glucosidase and α - amylase enzymes that effect on diabetes and anticancer effect on two type of cancer cell the first was: CaCo 2 cell of colon and the hot ex have the highest inhibition % than other extracts, and the second was 549 cells of homo sapiens epithial adherent cancer cell and cold extract was the highest inhibition % against it. In this study we concluded that all aqueous extracts had higher effect as antioxidant, antidiabetic and anticancer than ethanolic.
Modern interpretation of the essential characteristics of strategic management of the development of labor potential

The article is devoted to generating a modern interpretation of the essential characteristic of strategic management of the development of labor potential. A comparative analysis of the evolution of scientists' approaches to the interpretation of the essential characteristics of the categories "strategic management" and "labor potential" in the period 2003-2018 was carried out. According to the results of the content analysis, the key features of the definitions of the categories "strategic management" and "labor potential" available in the scientific literature were identified, in particular: for the category "strategic management" – dynamism, openness, flexibility (adaptability), purposefulness, predictability (orientation towards the future), systematicity, cyclicality, complexity, long-term, attainability, effectiveness, availability of resources, compliance with the mission (visions, concepts); for the category "labor potential" – the unity of realized potential and unrealized potential, the unity of quantitative characteristics and qualitative characteristics, complex structure, multilevel, multifactor, turbulence, orientation towards achieving a goal (plan, result). On the basis of the synthesis of the identified key features of the definitions of the categories "strategic management" and "labor potential" available in the scientific literature, a modern interpretation of the essential characteristics of strategic management of the development of labor potential was generated as: strategic management of the development of labor potential is a dynamic systemic process of complex purposeful influence on the quantitative and qualitative characteristics of labor potential carriers with the aim of ensuring the most effective realization of all components of labor potential and achieving long-term goals at the micro-, meso- and macro- levels in accordance with the mission (vision, concept) in conditions of turbulence of the external and internal environment and limited resources. The interpretation of the essential characteristics of strategic management of the development of labor potential offered by the authors is modern, because it takes into account the key features of the definitions of the categories "strategic management" and "labor potential". The modern interpretation of the essential characteristics of strategic management of the development of labor potential harmoniously complements the theoretical and scientific basis of the strategic management of the development of labor potential.
Análisis de contraste multiescala en imágenes de laser speckle

Laser Speckle Imaging (LSI) is a useful technique in medical applications since it provides information about blood flow and vascular. Traditional LSI uses standard window sizes (5×5 or 7×7) for contrast computing without taking into account the size of the ROIs (blood vessels). The speckle noise affects the whole image, however, the blood vessel region is smoother. On the one hand, a small window preserves spatial resolution but it barely attenuates the speckle noise; on the other hand, a large window significantly reduces the noise at the expense of losing spatial resolution and small ROIs. Therefore, a window size that fits with the size of the blood vessel is the one that can deal with the noise/resolution trade-off adequately. This paper proposes an automatic methodology, based on granulometry analysis, to estimate the accurate window size for contrast computation in a speckle image. The results are compared with traditional techniques for LSI.
Editorial: Fat metabolism and deposition in poultry: physiology, genetics, nutrition Volume II

As we described in our previous editorial for volume I of this Research Topic, modern broilers have been subjected to extensive genetic selection to improve feed efficiency and achieve high growth rate and muscle yield. However, this has concomitantly led to excessive fat deposition, which has increased the incidence of metabolic and cardiac disorders along with elevated sudden death rate (Squires and Summers, 1993; Chen et al., 2017; Olkowski et al., 2020). In continuity to the volume I, where we gathered several elegant papers describing the ontology of lipid metabolism in fat tissue and omics-associated factors regulating hepatic fat metabolism in chickens, we invited outstanding authors and pioneer scientists to further provide and highlight additional knowledges through innovative scientific research. Andrieux and others have optimized the embryonic thermo-conditioning that increased foie gras production without quality alteration and this effect was mediated via hepatic metabolism reprogramming (Andrieux et al.). Luo and co-workers determined, by using gas chromatography-mass spectrometry (GCMS) and untargeted metabolomics, the main volatile organic compounds (VOC) in chicken breast muscle and abdominal fat (Luo et al.). They identified nine VOCs in both tissues and found that amino acids are the main precursors of 1-octen-3-ol, (E,E)-2, 4-nonadienal, and heptanal in chicken meat, while fatty acids are the main precursors of diethyl disulfide. Hexanal, however, can be synthesized from amino acids and small amounts of fatty acids as precursors. Hicks and colleagues investigated the hepatic cell cycle transcriptional profile and network during the metabolic switch in broilers. They used high throughput RNA-seq to identify the transcriptome profile and differences in and between the liver of E18 embryos and 2-day post hatch chicks fed or not fed from hatch. Hundred of differentially expressed genes were identified between the abovementioned groups and I encourage the readers to check this manuscript (Hicks et al.). Kong et al., on the other hand, used integrated high throughput metabolomics and lipidomics to evaluate the alterations of flavor precursors in chicken breast muscleaffected with white striping. The white striping myopathy, first appeared in 2009 (Bauermeister et al., 2009), is visually characterized by white fat striations parallel to muscle fibers on the breast (Kuttappan et al., 2013), and is of increasing concern to the OPEN ACCESS
On the reflected random walk on R

Let ρ be a borelian probability measure on R having a moment of order 1 and a drift λ = ∫Rydρ(y) < 0. Consider the random walk on R+ starting at x ∈ R+ and defined for any n ∈N by \begin{eqnarray*} \left\{\begin{array}{rl} X_0&=x \\ X_{n+1} & = |X_n+Y_{n+1}| \end{array}\right. \end{eqnarray*} where (Yn) is an iid sequence of law ρ. We denote P the Markov operator associated to this random walk and, for any borelian bounded function f on R+, we call Poisson’s equation the equation f = g − Pg with unknown function g. In this paper, we prove that under a regularity condition on ρ and f, there is a solution to Poisson’s equation converging to 0 at infinity. Then, we use this result to prove the functional central limit theorem and it’s almost-sure version.
Reliability Improvement of Low-Temperature Sintered Nano-Silver as Die Attachment by Porosity Optimization

Thermomechanical stress caused by the coefficient of thermal expansion (CTE) mismatch leads to the formation of cracks, delamination, and warpage in the sintered nano-silver (S-Ag) layer, which eventually results in the fatigue failure of silicon carbide (SiC) semiconductor devices. Herein, the gradient porosity distribution method was proposed to simultaneously reduce the maximum thermomechanical stress and homogenize the stress distribution. The influence of different porosity distributions on the maximum thermomechanical stress and strain in the S-Ag layer was investigated by the finite element simulation. The gradient porosity distribution structure (<inline-formula> <tex-math notation="LaTeX">$S_{1 > 2}$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$S_{1 < 2}$ </tex-math></inline-formula>) effectively reduced the maximum thermomechanical stress and strain by 8.4% and 8.0% compared to the conventional uniform porosity structure (<inline-formula> <tex-math notation="LaTeX">$S_{1 = 2}$ </tex-math></inline-formula>). S-Ag bonding samples with <inline-formula> <tex-math notation="LaTeX">$S_{1 = 2}$ </tex-math></inline-formula>, <inline-formula> <tex-math notation="LaTeX">$S_{1 > 2}$ </tex-math></inline-formula>, and <inline-formula> <tex-math notation="LaTeX">$S_{1 < 2}$ </tex-math></inline-formula> structures were prepared to confirm the simulation results, which exhibited similar shear strengths. After 500 cycles of thermal shock test, the delamination rates of <inline-formula> <tex-math notation="LaTeX">$S_{1 > 2}$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$S_{1 < 2}$ </tex-math></inline-formula> bonding samples were 7.7% and 9.8%, which were 5.0% and 2.9% lower than <inline-formula> <tex-math notation="LaTeX">$S_{1 = 2}$ </tex-math></inline-formula> bonding samples, respectively. Both finite element simulation and experimental verification results demonstrate the positive effect of gradient porosity distribution structure on alleviating the thermomechanical fatigue failure caused by CTE mismatch.
Exploring “Enabling Behaviours” of Wives of Persons with Substance Use Disorder in Chapter 8 of the Big Book of Alcoholic Anonymous

Substance use disorder has a damaging effect on the family members of alcoholics and drug users. On the other hand, the reactions and behaviours of family members may negatively influence a person with substance use disorder. The behaviours of significant others of a person with substance use disorder that contribute to the maintenance of substance use disorder are called enabling. This study aimed to explore enabling behaviours of wives of persons with substance use disorder in Chapter 8 of Alcoholic Anonymous’ Big Book by utilising qualitative content analysis. Alcoholics Anonymous (AA) is one of the most commonly used programs for recovery from alcoholism. The current study sought to help mental health professionals get a better understanding of the views and premises of the AA program in reference to enabling behaviours of wives by conducting a qualitative content analysis of the AA Big Book. The study also discusses the healthy behaviours suggested by the authors of the Big Book and the comprehensiveness of the text for the readers.
Structural Adaptation of the Excitation–Contraction Coupling Apparatus in Calsequestrin1-Null Mice during Postnatal Development

Simple Summary The efficiency of the contractile machinery in muscle fibers is affected by the adequate development of skeletal muscle. CASQ1 knockout impairs the correct assembly of the excitation–contraction coupling apparatus and functional properties. In this study, to obtain further clues on CASQ1 functions, we characterized the ultrastructural alterations and examined the maturation of calcium release units, as well as the involvement of different junctional proteins in juxtaposition of the membrane system in skeletal muscle fibers during development from birth to the adult age. In the calcium release units, junctional proteins directly linked to CASQ1 exhibit a modified expression pattern during postnatal development, resulting in a delayed maturation process. In summary, our findings demonstrate that CASQ1 is essential for the full maturation of calcium release units during postnatal development. The disruption caused by its absence affects the correct assembly and coordination of junctional proteins, resulting in impaired Transverse-tubule biogenesis and altered muscle morphology. This study enhances our understanding of the intricate mechanisms underlying calcium release units formation and highlights the critical role of CASQ1 in this process. Abstract The precise arrangement and peculiar interaction of transverse tubule (T-tubule) and sarcoplasmic reticulum (SR) membranes efficiently guarantee adequate contractile properties of skeletal muscle fibers. Fast muscle fibers from mice lacking calsequestrin 1 (CASQ1) are characterized by the profound ultrastructural remodeling of T-tubule/SR junctions. This study investigates the role of CASQ1, an essential component of calcium release units (CRUs), in the postnatal development of muscle fibers. By using CASQ1-knockout mice, we examined the maturation of CRUs and the involvement of different junctional proteins in the juxtaposition of the membrane system. Our morphological investigation of both wild-type (WT) and CASQ1-null extensor digitorum longus (EDL) fibers, from 1 week to 4 months of age, yielded noteworthy findings. Firstly, we observed that the absence of CASQ1 hindered the full maturation of CRUs, despite the correct localization of key junctional components (ryanodine receptor, dihydropyridine receptor, and triadin) to the junctional SR in adult animals. Furthermore, analysis of protein expression profiles related to T-tubule biogenesis and organization (junctophilin 1, amphiphysin 2, caveolin 3, and mitsugumin 29) demonstrated delayed progression in their expression during postnatal development in the absence of CASQ1, suggesting the impaired maturation of CRUs. The absence of CASQ1 directly impacts the proper assembly of CRUs during development and influences the expression and coordination of other proteins involved in T-tubule biogenesis and organization.
A Magnetic Isolation Multichannel Driver With a Wide Range of Pulsewidths for Pulse Generators

Solid-state Marx generators have been widely used to generate repetitive high-voltage pulses for applications including dielectric barrier discharge (DBD) and biomedical engineering. However, the widely used magnetic isolated drive circuits can only operate with limited pulsewidth ranges due to the saturation of magnetic cores. To generate driving signals with a range from sub-microseconds to milliseconds, we propose a magnetic isolation multichannel drive circuit with a wide range of pulsewidths. It includes a low-side circuit with four switches and an inductor, many transformers, and passive gate circuits with gate charges remaining effect. The primary windings of transformers in series ensure the isolated driving of switches. Some energy previously stored in the inductor helps to accelerate the turning off of switches, and no dead time between switching is required. Therefore, sub-microsecond short pulses can be obtained. The passive gate circuits enable switches holding on and off, so long pulses are also possible. Based on this driver, a 32-stage Marx generator was developed and 20-kV pulses at a repetition frequency of 1 kHz were obtained. The pulsewidth ranges from 150 ns to $50~\mu \text{s}$ , which meets the requirements of most solid-state pulse generators.
Controlling output of chaotic economic three-dimensional object with incomplete description into target state

Application of the method of analytical design of aggregated regulators for constructing systems of control over nonlinear objects under the conditions of uncertainty (with incomplete description) is discussed. The controlled objects are presented as a system of ordinary noninear differential or difference equations with chaotic behavior in case of certain combinations of parameters. The formulation of control problem for a poorly formalized object is given and the synthesis control algorithm is presented and theoretically validated. Illustrative example of application of the proposed algorithm is provided along with its numerical simulation data. The results obtained would be useful in developing an intelligent control system and making decisions in real time in control policy of various application objects in robotics, in control of electromechanical objects, economic entities, etc.) Keywords—Multidimensional nonlinear object, target manifold, adaptation to manifolds, bounded noise with unknown description
POR QUE OS JOGADORES DE FORTNITE COMPRAM ITENS VIRTUAIS COSMÉTICOS? IMPLICAÇÕES PARA A GESTÃO DE MARKETING.

Esta pesquisa tem como objetivo, analisar as motivações que influenciam os gamers a consumirem skins cosméticas no jogo Fortnite, no Brasil. Os dados foram coletados por meio de entrevistas online, com jogadores selecionados do grupo Fortnite Brasil da rede social Facebook, com questões sobre motivações de consumo, além da técnica de análise de conteúdo qualitativa. Observou-se a presença de todos os fatores, funcionais, hedônicos e sociais, sendo que a variável de reciprocidade e de aumentar a longevidade no jogo foi pouco percebida. Além disso, identificou-se que os jogadores atuais também consomem esses itens como formas de investimento. Palavras-Chave: Itens virtuais cosméticos. Skins. Motivações de consumo. Marketing. Fortnite. Abstract: This research aims to analyse the motivations that influence gamers to consume skins in Fortnite, in Brazil. Data were collected through online interviews with selected players from the Fortnite Brazil group on Facebook, with consuming motivations questions, in addition to the technique of qualitative content analysis. The presence of all factors, functional, hedonic and social, was observed, and the variable of reciprocity and increasing longevity of the game were little perceived. In addition, it was identified that current players also consume and see these items as a form of investment. Keywords: Cosmetic Virtual Itens. Skins. Consuming Motivations. Marketing. Fortnite.
Deployment of Rotavirus Vaccine in Western Kenya Coincides with a Reduction in All-Cause Child Mortality: A Retrospective Cohort Study

Rotavirus is an important cause of fatal pediatric diarrhea worldwide. Many national immunization programs began adding rotavirus vaccine following a 2009 World Health Organization recommendation. Kenya added rotavirus vaccine to their immunization program at the end of 2014. From a cohort of 38,463 children in the Kisumu health and demographic surveillance site in western Kenya, we assessed how the implementation of the rotavirus vaccine affected mortality in children under 3 years of age. Following its introduction in late 2014, the span of rotavirus vaccine coverage for children increased to 75% by 2017. Receiving the rotavirus vaccine was associated with a 44% reduction in all-cause child mortality (95% confidence interval = 28–68%, p < 0.0001), but not diarrhea-specific mortality (p = 0.401). All-cause child mortality declined 2% per month following the implementation of the rotavirus vaccine (p = 0.002) among both vaccinated and unvaccinated children, but diarrhea-specific mortality was not associated with the implementation of the rotavirus vaccine independent of individual vaccine status (p = 0.125). The incidence of acute diarrhea decreased over the study period, and the introduction of the rotavirus vaccine was not associated with population-wide trends (p = 0.452). The receipt of the rotavirus vaccine was associated with a 34% reduction in the incidence of diarrhea (95% confidence interval = 24–43% reduction). These results suggest that rotavirus vaccine may have had an impact on all-cause child mortality. The analyses of diarrhea-specific mortality were limited by relatively few deaths (n = 57), as others have found a strong reduction in diarrhea-specific mortality. Selection bias may have played a part in these results—children receiving rotavirus vaccine were more likely to be fully immunized than children not receiving the rotavirus vaccine.
Ru and Se Co-Doped Cobalt Hydroxide Electrocatalyst for Efficient Hydrogen Evolution Reactions

The development of efficient electrocatalysts for hydrogen evolution reactions is an extremely important area for the development of green and clean energy. In this work, a precursor material was successfully prepared via electrodeposition of two doping elements to construct a co-doped cobalt hydroxide electrocatalyst (Ru-Co(OH)2-Se). This approach was demonstrated to be an effective way to improve the performance of the hydrogen evolution reaction (HER). The experimental results show that the material exhibited a smaller impedance value and a larger electrochemically active surface area. In the HER process, the overpotential was only 109 mV at a current density of 10 mA/cm2. In addition, the doping of selenium and ruthenium effectively prevented the corrosion of the catalysts, with the (Ru-Co(OH)2-Se) material showing no significant reduction in the catalytic performance after 50 h. This synergistic approach through elemental co-doping demonstrated good results in the HER process.
Genus Acrostalagmus: A Prolific Producer of Natural Products

Acrostalagmus is known for its ability to produce numerous bioactive natural products, making it valuable in drug development. This review provides information on the sources, distribution, chemical structure types, biosynthesis, and biological activities of the compounds isolated from the genus Acrostalagmus in the family Plectosphaerellaceae from 1969 to 2022. The results show that 50% of the compounds isolated from Acrostalagmus are new natural products, and 82% of the natural products derived from this genus are from the marine Acrostalagmus. The compounds isolated from Acrostalagmus exhibit diverse structures, with alkaloids being of particular importance, accounting for 56% of the natural products derived from this genus. Furthermore, within the alkaloid class, 61% belong to the epipolythiodioxopiperazine family, highlighting the significance of epipolythiodioxopiperazine as a key characteristic structure within Acrostalagmus. Seventy-two percent of natural products derived from Acrostalagmus display bioactivities, with 50% of the bioactive compounds exhibiting more significant or comparable activities than their positive controls. Interestingly, 89% of potent active compounds are derived from marine fungi, demonstrating their promising potential for development. These findings underscore Acrostalagmus, particularly the marine-derived genus Acrostalagmusas, a valuable source of new bioactive secondary metabolites, and emphasize the vast resource importance of the ocean.