Miracle-dz/UniFAR-FTUs huggingface dataset:
Emerging Roles of COX7RP and Mitochondrial Oxidative Phosphorylation in Breast Cancer

Metabolic alterations are critical events in cancers, which often contribute to tumor pathophysiology. While aerobic glycolysis is a known characteristic of cancer-related metabolism, recent studies have shed light on mitochondria-related metabolic pathways in cancer biology, including oxidative phosphorylation (OXPHOS), amino acid and lipid metabolism, nucleic acid metabolism, and redox regulation. Breast cancer is the most common cancer in women; thus, elucidation of breast cancer-related metabolic alteration will help to develop cancer drugs for many patients. We here aim to define the contribution of mitochondrial metabolism to breast cancer biology. The relevance of OXPHOS in breast cancer has been recently defined by the discovery of COX7RP, which promotes mitochondrial respiratory supercomplex assembly and glutamine metabolism: the latter is also shown to promote nucleic acid and fatty acid biosynthesis as well as ROS defense regulation. In this context, the estrogen-related receptor (ERR) family nuclear receptors and collaborating coactivators peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) are essential transcriptional regulators for both energy production and cancer-related metabolism. Summarizing recent findings of mitochondrial metabolism in breast cancer, this review will aim to provide a clue for the development of alternative clinical management by modulating the activities of responsible molecules involved in disease-specific metabolic alterations.
Total Mesorectal Excision vs. Transanal Endoscopic Microsurgery Followed by Radiotherapy for T2N0M0 Distal Rectal Cancer: A Multicenter Randomized Trial

Introduction Transanal endoscopic microsurgery (TEM) is an organ-preserving treatment alternative for patients with early rectal cancer. However, TEM alone is associated with greater risk of local recurrence and inferior survival in comparison with total meso-rectal excision (TME). As an important adjuvant therapy, radiotherapy can effectively reduce the local recurrence rate of rectal cancer. This study aimed to investigate whether TEM followed by radiotherapy can be a valid alternative to TME in T2N0M0 distal rectal cancer treatment. Methods We plan to recruit 168 participants meeting established inclusion criteria. Following informed consent, participants will randomly receive treatment protocols of TEM followed by radiotherapy (a total dose of 45–50.4 Gy given in 25–28 factions) or TME. Depending on post-operative pathology, the participants will receive either long-term follow-up or further treatment. The primary endpoint of this trial is 3-year local recurrence rate. The secondary end points include 3-year disease-free survival rate, 3-year overall survival rate, 3-year mortality rate, post-operative quality of life, post-operative safety index, intraoperative evaluation index and post-operative short-term evaluation index. Discussion This trial is the first prospective randomized trial to investigate the rectum preserving treatment by using transanal local excision followed by radiotherapy. Clinical trial registration The trial was prospectively registered at ClinicalTrials.gov NCT04098471 on September 20, 2019.
Research on Chinese Consumers’ Attitudes Analysis of Big-Data Driven Price Discrimination Based on Machine Learning

From the end of 2018 in China, the Big-data Driven Price Discrimination (BDPD) of online consumption raised public debate on social media. To study the consumers’ attitude about the BDPD, this study constructed a semantic recognition frame to deconstruct the Affection-Behavior-Cognition (ABC) consumer attitude theory using machine learning models inclusive of the Labeled Latent Dirichlet Allocation (LDA), Long Short-Term Memory (LSTM), and Snow Natural Language Processing (NLP), based on social media comments text dataset. Similar to the questionnaires published results, this article verified that 61% of consumers expressed negative sentiment toward BDPD in general. Differently, on a finer scale, this study further measured the negative sentiments that differ significantly among different topics. The measurement results show that the topics “Regular Customers Priced High” (69%) and “Usage Intention” (67%) occupy the top two places of negative sentiment among consumers, and the topic “Precision Marketing” (42%) is at the bottom. Moreover, semantic recognition results that 49% of consumers’ comments involve multiple topics, indicating that consumers have a pretty clear cognition of the complex status of the BDPD. Importantly, this study found some topics that had not been focused on in previous studies, such as more than 8% of consumers calling for government and legal departments to regulate BDPD behavior, which indicates that quite enough consumers are losing confidence in the self-discipline of the platform enterprises. Another interesting result is that consumers who pursue solutions to the BDPD belong to two mutually exclusive groups: government protection and self-protection. The significance of this study is that it reminds the e-commerce platforms to pay attention to the potential harm for consumers’ psychology while bringing additional profits through the BDPD. Otherwise, the negative consumer attitudes may cause damage to brand image, business reputation, and the sustainable development of the platforms themselves. It also provides the government supervision departments an advanced analysis method reference for more effective administration to protect social fairness.
Relationship between sociodemographics, healthcare providers’ competence and healthcare access among two-spirit, gay, bisexual, queer and other men who have sex with men in Manitoba: results from a community-based cross-sectional study

Objective Little is known about barriers to healthcare access for two-spirit, gay, bisexual and queer (2SGBQ+) men in Manitoba. Design Data were drawn from a community-based, cross-sectional survey designed to examine health and healthcare access among 2SGBQ+ men. Setting Community-based cross-sectional study in Manitoba, Canada. Participants Community-based sample of 368 2SGBQ+ men. Outcomes Logistic regression analyses assessed the relationship between sociodemographics, healthcare discrimination, perceived healthcare providers’ 2SGBQ+ competence/knowledge and two indicators of healthcare access (analytic outcome variables): (1) having a regular healthcare provider and (2) having had a healthcare visit in the past 12 months. Results In multivariate analyses, living in Brandon (adjusted OR (AOR)=0.08, 95% CI 0.03 to 0.22), small cities (AOR=0.20, 95% CI 0.04 to 0.98) and smaller towns (AOR=0.26, 95% CI 0.08 o 0.81) in Manitoba (compared with living in Winnipeg), as well as having a healthcare provider with poor (AOR=0.19, 95% CI 0.04 to 0.90) or very poor competence/knowledge (AOR=0.03, 95% CI 0.03 to 0.25) of 2SGBQ+ men’s issues (compared with very good competence) was associated with lower odds of having a regular healthcare provider. Living in Brandon (AOR=0.05, 95% CI 0.02 to 0.17) and smaller towns (AOR=0.25, 95% CI 0.67 to 0.90) in Manitoba (compared with living in Winnipeg) was associated with lower odds of having a healthcare visit in the past 12 months, while identifying as a gay man compared with bisexual (AOR=12.57, 95% CI 1.88 to 83.97) was associated with higher odds of having a healthcare visit in the past 12 months. Conclusions These findings underscore the importance of reducing the gap between the healthcare access of rural and urban 2SGBQ+ men, improving healthcare providers’ cultural competence and addressing their lack of knowledge of 2SGBQ+ men’s issues.
Digitally Implemented Novel Technique to Approach Natural Sampling SPWM

Abstract Digital signal processor (DSP) based sinusoidal pulse width modulation (SPWM) uses symmetrical and asymmetrical regular sampling. These samplings do not attain the performance of natural SPWM at low sampling. This paper presents a simple technique using digital sampling to approach naturally sampled SPWM. The proposed technique samples the modulating waveform at every peak of the triangular carrier signal and calculates precise magnitude of modulating signal for the instant of intersection. This signal has enough information to minimize the error in switching instant. The original modulating signal appears in the PWM output spectra unattenuated, without any distortion components, and without phase delay, regardless of the frequency or modulation depth of that signal. The presented technique is suitable for real time implementation using commercial DSP. This technique is also applicable to multilevel inverter and does not generate superfluous pulses like asymmetrical sampling in the output voltage of multilevel inverter. Simulation and experimental results are presented to demonstrate and confirm the validity of the proposed technique.
Conceptualizing Humane Buying and Its Role in Reducing Rural Farmers’ Vulnerability in a Post-Pandemic Era

While several studies have examined the impact of the Covid-19 pandemic on smallholder rural farmers and possible efforts to scale up their livelihood and food security, the role of consumers’ buying orientation in addressing farmers’ vulnerability in the post-pandemic era has not been explored. The paper, therefore, aims to propose and conceptualize humane buying orientation, and further explore its role in attenuating smallholder rural farmers’ vulnerability in the new normal. The qualitative design approach has been employed in two different studies. Collected data were analyzed using the SPSS 23.0 and following the interpretative phenomenological analysis. Findings validate humane buying as an altruistic orientation that will contribute to lessening the vulnerability of smallholder rural farmers in the post-pandemic era. It also shows that an enlarged-stakeholders’ (government, international agencies, corporate bodies, institutions, Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 3 November 2021 © 2021 by the author(s). Distributed under a Creative Commons CC BY license. doi:10.20944/preprints202111.0069. v1
Cascaded H-bridge Multilevel Inverter for High Precision and Linear Control of the Rate of Ozone Yielding

A multilevel inverter employing a cascade transformer is proposed for a silent-discharge-tube ozone generating system. The proposed inverter consists of four full-bridge inverters and fourteen transformers which have a series-connected secondary. It can accurately control the amplitude of the output voltage; hereby, it improves a linear characteristic of the rate of ozone yielding. The power regulation characteristics and operational principle of the proposed system are explained from a practical point of view. High precision ozone generating performance of the proposed multilevel inverter is verified by computer-aided simulations and experiment results.
Genomic Changes within a Subset of IncI2 Plasmids Associated with Dissemination of mcr-1 Genes and Other Important Antimicrobial Resistance Determinants

IncI2 plasmids appear to have only recently become associated with resistance genes; however, their tendency to carry resistance to the antibiotics of last resort and their widespread distribution increase their relative importance. In this study, we describe lineages within this plasmid family that have an increased likelihood of acquisition of antimicrobial resistance genes. Globally distributed mcr-1-carrying IncI2 plasmids were found to cluster with other IncI2 plasmids carrying extended-spectrum beta-lactamase genes, and separately from the non-resistant IncI2 plasmids. In addition, insertion sequence (IS) elements with no direct association with the acquired resistance genes also clustered with the resistance plasmids in the phylogenetic tree. In recognition of the biased sequencing of resistant plasmids globally, the analysis was also performed on resistant and non-resistant IncI2 plasmids sequenced in the USA through government surveillance efforts that do not rely on antibiotic selection. This analysis confirmed a distinct clustering associated with both resistance and mobile elements and identified possible genomic changes in core genes that correlate with increased acquisition of foreign DNA. This work highlights a potential genetic mechanism for increased uptake of foreign DNA within this prevalent family of plasmids.
The Refraction Assessment and the Electronic Trial Frame Measurement during Standing or Sitting Position Can Affect Postural Stability

Vision has been shown to influence body posture. The purpose of this study is to investigate the correlations between visual acuity and body postural control both in a standing and seated position. This cohort study included 37 patients examined using Adaptica’s (Italy) Kaleidos and VisionFit. Objective refraction was measured with Kaleidos both in a standing and seated position by the same operator and in the same environmental conditions. The parameters obtained with the device were binocular refraction, monocular refraction, pupil distance, pupil size, head tilt, gaze, phorias, and tropias. The results obtained were then subjectively tested using VisionFit: an electronic trial frame with phoropter functionalities. The study’s outcome revealed that the differences in the visual acuity parameters obtained in standing and seated positions were statistically significant; the Student’s t-test showed a p-value < 0.001 in all parameter averages. Automated refraction is widely being performed and postural control can affect the visual acuity parameters; therefore, it is relevant to consider the possibility of measuring in orthostatism. It might be appropriate to take into account the possibility of measuring in orthostatism and wearing trial frames in orthostatic conditions as well as walking freely around the room, looking outside of a window, sitting, and reading.
High Level of miR-18a Promote Radiotherapy Progress in Non-Small Cell Lung Cancer

Palliative radiotherapy has become an important treatment way for local control of advanced Non-Small Cell Lung Cancer (NSCLC). Current investigation aims to clarify miR-18a as a predictor of radiotherapy sensitivity, its cutoff value for predicting response. 70 patients with NSCLC were enrolled for radiotherapy during the period of 2018-2020. The level of miR-18a in blood were detected by using Quantitative PCR. Another seven variances including age, sex, smoking history, pathologic stage, radiation therapy days, radiation dosage and radiation type were enrolled to predict radiation therapy response. The level of hasmiR- 18a showed higher in patients with poor effects after radiation therapy (P<0.001). The optimal cut-off value of 18.287 for miR-18a alone with AUC of 0.879 (95% confidence interval, 0.8-0.958) can predict the radiation therapy effectiveness. Hsa-mir-18a is significantly positive (β1=-0.2845, P=0.0001) in logistical regression model AUC of 0.89 (95% confidence interval, 0.811-0.97). Hsa-mir-18a is the most important factors in random forest model with an AUC of 0.69 (95% confidence interval, 0.6-0.82) for predicting the radiation therapy effectiveness. High expressed hsa-mir-18a positively correlated with radiation therapy progress in patients with advanced NSCLC.
Sutureless versus Hand-Sewn Coronary Anastomoses: A Systematic Review and Meta-Analysis

Background: Sutureless coronary anastomotic devices are intended to facilitate minimally invasive coronary artery bypass grafting (MICS-CABG) by easing and eventually standardizing the anastomotic technique. Within this systematic review and meta-analysis, we aim to determine patency and to evaluate safety outcomes for the sutureless anastomoses. Methods: CENTRAL, MEDLINE, and EMBASE were searched from database start till August 2021 in a predefined search strategy combining the key concepts: ‘coronary artery bypass grafting’, ‘sutureless coronary anastomoses’, and ‘hand-sewn coronary anastomoses’ by the Boolean operation ‘AND’. Study characteristics, patient demographics, interventional details, and all available outcome data were extracted. A meta-analysis was performed on patency at longest follow-up. Safety outcomes were presented. Results: A total of eleven trials towards six sutureless anastomotic devices were included, comprising 3724 patients (490 sutureless and 3234 hand-sewn). There was no significant difference in patency at a mean follow-up duration of 546.3 (range 1.5–2691) days, with a risk ratio of 0.77 (95% CI 0.55–1.06). MACE was reported in 4.5% sutureless and 3.9% hand-sewn patients, including all-cause mortality (resp. 1.3 vs. 1.9%), myocardial infarction (resp. 1.6 vs. 1.7%), and coronary revascularization (resp. 1.8 vs. 0.5%). Incomplete hemostasis occurred in 24.8% of the sutureless anastomoses. Intra-operative device failure forced conversion to hand-sewn or redo-anastomosis in 5.8% of the sutureless cases. Conclusion: Based on the systematic review and meta-analysis including six devices, we conclude that sutureless coronary anastomotic devices appear safe and effective when used by well-trained and dedicated surgical teams.
Far field wall-mounted microphone device for the S1MA anechoic closed-section wind tunnel applied to Open Rotor

The present paper aims at introducing the new far f ield wall-mounted microphone device for the ONERA S1MA anechoic closed-section wind tunnel. This new device is based on previous research where metallic cloths (wiremesh) and recessed microphones prevent spurious hydrodynamic fluctuations without disturbing the acoustic measurement. This instrumentation is used for the far field acoustic directivity of an Open Rotor. In order to assess the acoustic quality of S1MA, the measurements are compared to those from another anechoic closed test-section wind tunnel.
Neighborhood Poverty in Combination with Older Housing Is Associated with Adverse Birth Outcomes: A Study on Ubiquitous Lead Risk among 1 Million Births in Texas

The purpose of this study was to determine whether housing age in combination with neighborhood poverty, as a proxy for fetal exposure to heavy metal lead, is associated with adverse birth outcomes. We linked population-level birth certificate data for Black, Hispanic, White and Other women, stratified by nativity, from 2009–2011 in Texas (n = 1,040,642) to census the tract-level median housing age/poverty level from the American Community Survey, 2007–2011. Tracts with median housing age values before 1975 with a poverty level of 20% or more were considered to be neighborhoods with a high risk of exposure to deteriorating lead-based paint. We estimated multilevel models to examine the relationship between neighborhood housing age/poverty level and each dependent variable (preterm birth, low birth weight, small-for-gestational age). The odds of adverse birth outcomes were significantly higher for mothers living in high-poverty neighborhoods with median housing built before the lead-based paint ban. Increased awareness of—and improved methods of alleviating— ubiquitous lead-based paint exposure in Texas may be necessary interventions for positive developmental trajectories of children. Allocating federal funds for place-based interventions, including universal lead paint mitigation, in older, high-poverty neighborhoods may reduce the disproportionate risk of adverse birth outcomes.
Reutilisation of Water Contaminated by Mining Waste for the Encapsulation of Potentially Toxic Elements

Mining activities are essential for a population’s development; however, they also produce negative effects such as the production of waste, an impact on flora and water pollution. On the other hand, construction is one of the sectors which is most demanding of raw materials, with one of the main such materials being water. For this reason, this research evaluates the feasibility of incorporating water contaminated by mining waste into ceramic materials for bricks. In this way, the use of water is reduced and, on the other hand, the contaminating elements of the mining water are encapsulated in the ceramic matrix. To achieve this, the clay used and the contaminated water were first analysed, then different families of samples were conformed with different percentages of contaminated water. These samples were tested to determine their physical and mechanical properties. At the same time, leachate tests were carried out to determine that the ceramic material created did not cause environmental problems. The test results showed that the physical and mechanical properties of the ceramics were not influenced by the addition of contaminated water. On the other hand, the leachate tests showed that encapsulation of most of the potentially toxic elements occurred. However, the use of contaminated water as mixing water for ceramics could only be performed up to 60%, as higher percentages would leach impermissible arsenic concentrations. Accordingly, a new way of reusing water contaminated by mining activities is developed in this study, taking advantage of resources, avoiding environmental pollution and creating economic and environmentally friendly end products.
COVID-19 Information Overload and Cyber Aggression during the Pandemic Lockdown: The Mediating Role of Depression/Anxiety and the Moderating Role of Confucian Responsibility Thinking

Many countries adopted lockdown measures to curb the spread of the outbreak in 2020, while information about COVID-19 has dominated various media outlets, which has led to information overload for people. However, previous research has mainly focused on cancer information overload and the corresponding consequence, and failed to examine its adverse effects in the context of major public health events. Based on the Frustrate Aggression Theory and the Scapegoat Theory, the present study established a moderated mediation model to investigate the emotional and behavioral outcomes of COVID-19 information overload. The mediating role of depression/anxiety in the association between COVID-19 information overload and cyber aggression, as well as the moderating role of Confucian responsibility thinking, were tested. This model was examined with 1005 Chinese people (mean age = 26.91 years, SD = 9.94) during the COVID-19 outbreak. Mediation analyses revealed that COVID-19 information overload was positively related to cyber aggression, depression, and anxiety, parallelly and partially mediated this relationship. Moderated mediation analyses further indicated that Confucian responsibility thinking not only moderated the direct link between COVID-19 information overload and cyber aggression, with the effect being significant only for people with a low level of Confucian responsibility thinking, but also moderated the relationship between COVID-19 information overload and depression/anxiety respectively, with the associations being much more potent for individuals with low levels of Confucian responsibility thinking. These findings have the potential to inform the development of prevention and intervention programs designed to reduce the negative emotions and cyber aggression associated with information overload in public health events.