Miracle-dz/UniFAR-FTUs huggingface dataset:
Association of Urinary Phthalate and Phthalate Replacement Metabolite Concentrations with Serum Lipid Biomarker Levels among Pregnant Women Attending a Fertility Center

We examined whether urinary concentrations of phthalate and phthalate replacement metabolites were associated with lipid biomarker levels among pregnant women. This cross-sectional study included 175 women who enrolled in the Environment and Reproductive Health (EARTH) Study (2005–2017). We used linear regression models to assess the relationship between urinary phthalates and lipid biomarkers [triglycerides, total cholesterol, high density lipoprotein (HDL), non-HDL, and low-density lipoprotein (LDL) cholesterol] levels while adjusting for confounders. Pregnant women in the highest quartile of urinary mono(2-ethyl-5-carboxypentyl) phthalate (MECPP) had, overall, 14% [31 (95% CI = 6.56) mg/dL], 21% [33 (95% CI = 9.57) mg/dL] and 25% [30 (95% CI = 8.53) mg/dL] higher serum total, non-HDL and LDL cholesterol, respectively, compared to women in the lowest quartile of MECPP. Similar positive associations were found for urinary concentrations of other metabolites of di(2-ethylhexyl) phthalate, mono(2-ethylhexyl) phthalate, and mono(2-ethyl-5-oxohexyl) phthalate. Pregnant women with urinary mono-n-butyl phthalate (MBP) in the highest quartile had higher triglycerides and non-HDL cholesterol compared to women with MBP in the lowest quartile. Women with detectable concentrations of two phthalate replacement metabolites had lower HDL cholesterol compared to women with non-detectable concentrations. Gestational urinary concentrations of certain phthalate and phthalate replacement metabolites were associated with lipid levels among these women.
Caracterización de tintas de cemento de fosfato de calcio con adición de Poloxámero 407 para su posible aplicación en impresión 3D

La impresión 3D de biomateriales es una tecnología de gran auge para la fabricación de injertos aptos para la reparación de defectos óseos con geometrías complejas. Los cementos de fosfato de calcio (CFC) son biocerámicos empleados en la medicina ortopédica debido a su similitud con la fase mineral del hueso, la capacidad para ser moldeados como una pasta y endurecer in situ. La impresión 3D de CFC potencializaría su aplicación al permitir cirugías reconstructivas de defectos con geometrías complejas, sin embargo, una limitante es la baja inyectabilidad de los CFC debido a la separación de fases que ocurre durante la inyección de la pasta. En este trabajo se ha estudiado la implementación de un polímero termosensible como el Poloxámero 407 para generar una tinta inyectable. Dicha tinta ha sido formulada para contener 5 % de hidroxiapatita carbonatada tipo B como agente nucleante biocompatible y biodegradable. Se evaluaron adiciones de soluciones acuosas de Poloxámero 407 al 0 %, 20 % y 40 % en peso como fase gel a una relación líquido/polvo de 0,75 mL/g. Se determinó el coeficiente de inyectabilidad, la cohesión de las tintas y se caracterizó la resistencia a la compresión de los cementos empleando análisis Weibull, determinado que la adición de polímero disminuye las propiedades mecánicas de los CFC en un 52,68 % y 81,23 %, respectivamente, en relación con el CFC de control (0%), atribuido a una menor densificación del cemento. Se concluyó que las adiciones del Poloxámero 407 no interfieren en la precipitación de hidroxiapatita deficiente en calcio ni en la degradación in vitro de los cementos y favorece el comportamiento de la tinta para su posible implementación en impresión 3D.
Understanding how digital transformation can enable SMEs to achieve sustainable development: A systematic literature review

Small and medium-sized enterprises (SMEs) are key drivers of economic growth and development. Innovation through digital transformation has the capacity to enable sustainability, competitiveness and customisation in products and services. However, adoption of digital technologies by SMEs to underpin sustainability outcomes is poorly understood. A systematic literature review identified an initial dataset of 1300 articles, which after screening and application of exclusion criteria resulted in a dataset of 64 articles for synthesis. Analysis was carried out according to three main areas, namely the technology aspects of digital transformation, sustainable development according to the triple bottom line (i.e. economic, environmental and social aspects), and the business characteristics of SMEs. In the latter case, business strategy and management, organizational structure, organizational culture, skills and qualifications, and leadership factors are identified from the literature. Furthermore, literature expressing the triple bottom line dimensions and the type of Industry 4.0 technology areas adopted are synthesized. Correlation of the data through bibliographic analysis is provided on the type of technology enabling SMEs towards a pathway for sustainable development as well as synthesis of future research directions arising from the study.
Cellular Damage in the Target and Out-Of-Field Peripheral Organs during VMAT SBRT Prostate Radiotherapy: An In Vitro Phantom-Based Study

Simple Summary New developments show that patients with prostate cancer can benefit from radiotherapy delivered with a hypo-fractionated regimen. The aim of our study was to investigate the effect of hypo-fractionated stereotactic body radiation therapy (SBRT) of prostate cancer on out-of-field organs. We used a humanoid phantom to irradiate prostate cells in conditions similar to patient therapy, using SBRT planning. Our results show that radiation doses in the location of the intestine and lung resulted in significantly higher radiation doses than the further locations. We observed a high radiotoxic effect in the cells irradiated in the prostate, and a small increase in DNA damage and cell killing in the intestine location. Gene expression analysis revealed significant enrichment of the biological processes related to the radiation response in the prostate. In the lung and thyroid, the enrichment of several gene groups was revealed, however the processes were not clearly related to the response to radiation. Our study provides extensive data on out-of-field safety of prostate SBRT. Abstract Hypo-fractionated stereotactic body radiation therapy (SBRT) is an effective treatment for prostate cancer (PCa). Although many studies have investigated the effects of SBRT on the prostate and adjacent organs, little is known about the effects further out-of-field. The aim of this study was to investigate, both in vitro and in a quasi-humanoid phantom, the biological effects (using a dose-scaling approach) of radiation in the out-of-field peripheral organs delivered by 6 MV volumetric modulated arc therapy (VMAT) SBRT in a prostate cancer model. Healthy prostate cells were irradiated in a phantom at locations corresponding to the prostate, intestine, lung, thyroid, and brain. Seven 10 Gy fractions of VMAT SBRT were delivered to the target in a single session without intermission (scaled-up method). Radiochromic films were used to measure the doses. The radiobiological response was assessed by measuring DNA breaks, the cell survival fraction, and differences in gene expression profile. Our results showed a strong, multiparametric radiobiological response of the cells in the prostate. Outside of the radiation field, the highest doses were observed in the intestine and lung. A small increase (not statistically significant) in DNA damage and cell death was observed in the intestines. Several gene groups (cell cycle, DNA replication) were depleted in the lung and thyroid (DNA replication, endocytosis), but further analysis revealed no changes in the relevant biological processes. This study provides extensive evidence of the types and extent of radiobiological responses during VMAT SBRT in a prostate cancer model. Additional research is needed to determine whether the radiobiological effects observed in the peripheral organs are validated in a clinical context.
Home-Based Self-Employment: Combining Personal, Household and Employment Influences

Despite the significant economic, innovative and social contributions of home-based self-employment, it is an under-researched and under-theorised area. We address this gap by drawing from established entrepreneurial theory to propose and validate a more complete theoretical model that combines personal, household and employment influences. We validate our proposed model by drawing on quantitative data from a large-scale, longitudinal, UK-based, social studies dataset. Our validated model demonstrates how and why antecedent and current household and employment factors, but not personal factors, associated with being home-based interact and provide constitutive affordances that result in a setting for self-employment that is unique in more fundamental ways than simply the home location of the business. Despite being responsible for some of the world’s most innovative and successful businesses, home-based businesses are often denigrated as lacking ambition or growth potential. The results of our analysis vindicate the choices of the home-based self-employed, by demonstrating that basing a business in the home is a rational choice based on an intersection of household and employment characteristics. The data used in this study predates the COVID-19 pandemic. However, it is expected that home-based self-employment will grow significantly following the pandemic in response to increasing acceptance of home-working. It therefore behoves entrepreneurship scholars to have a robust understanding of this previously overlooked type of self-employment if we are to be able to provide guidance to policymakers and self-employment support services.
PELAKSANAAN SURVEILANS EPIDEMIOLOGI DI PUSKESMAS SE-KOTA KENDARI TAHUN 2016

Puskesmas merupakan unit pelaksana teknis Dinas Kesehatan Kota yang bertanggung jawab menyelenggarakanpembangunan kesehatan di satu atau sebagian wilayah kecamatan. Pelaksanaan surveilans epidemiologimerupakan salah satu upaya untuk mengatasi masalah penyakit menular maupun penyakit tidak menular,mengurangi kesakitan, mencegah kematian, penyembuhan penderita dan mencegah terjadinya peningkatanpenyakit. Tujuan penelitian ini adalah mendeskripsikan pelaksanaan Surveilans Epidemiologi Penyakit danpermasalahannya di Puskesmas se-Kota Kendari tahun 2016 dilihat dari pengumpulan data, pengolahan data,analisis dan interpretasi data serta diseminasi informasi. Jenis penelitian kualitatif dengan pendekatan studikasus. Informan dalam penelitian ini adalah seluruh petugas surveilans Puskesmas tahun 2016 di Kendari dankoordinator surveilans Dinas Kesehatan Kota Kendari. Hasil penelitian menunjukan pelaksanaan surveilansmeliputi pengumpulan data yang dilakukan hanya mencakup data kesakitan berupa laporan penyakit danpemakaian obat dari Poli Umum, Pustu dan laporan masyarakat setempat. Pengolahan data surveilansdilakaukan secara manual dan hanya memanfaatkan komputer disajikan dalam bentuk tabel, grafik dan tekslaporan belum sampai pada penyajian pemetaan data dengan pemanfaatan progam Geographycal InformationSystem (GIS). Analisis dan interpretasi data dilakukan berdasarkan variabel epidemiologi (orang, waktu dantempat) yang dilakukan secara manual. Penyebarluasan data belum efektif karena pelaksanaannya belumsepenuhnya memanfaatkan teknologi yang ada dan tidak rutin dilakukan setiap bulan. Namun, ketersediantenaga kerja, pelatihan dalam mendukung keterampilan petugas surveilans, serta sarana dan prasana yangterdapat di setiap Puskesmas belum berjalan efektif sehingga menghambat pelaksanaan surveilans. Kata kunci : Surveilans, Penyakit Menular dan Tidak Menular, Puskesmas.
Nuclear and Radiological Emergencies: Biological Effects, Countermeasures and Biodosimetry

Atomic and radiological crises can be caused by accidents, military activities, terrorist assaults involving atomic installations, the explosion of nuclear devices, or the utilization of concealed radiation exposure devices. Direct damage is caused when radiation interacts directly with cellular components. Indirect effects are mainly caused by the generation of reactive oxygen species due to radiolysis of water molecules. Acute and persistent oxidative stress associates to radiation-induced biological damages. Biological impacts of atomic radiation exposure can be deterministic (in a period range a posteriori of the event and because of destructive tissue/organ harm) or stochastic (irregular, for example cell mutation related pathologies and heritable infections). Potential countermeasures according to a specific scenario require considering basic issues, e.g., the type of radiation, people directly affected and first responders, range of doses received and whether the exposure or contamination has affected the total body or is partial. This review focuses on available medical countermeasures (radioprotectors, radiomitigators, radionuclide scavengers), biodosimetry (biological and biophysical techniques that can be quantitatively correlated with the magnitude of the radiation dose received), and strategies to implement the response to an accidental radiation exposure. In the case of large-scale atomic or radiological events, the most ideal choice for triage, dose assessment and victim classification, is the utilization of global biodosimetry networks, in combination with the automation of strategies based on modular platforms.
Compromiso escolar en estudiantes de un liceo intercultural mapuche: un estudio cualitativo

Diversos estudios internacionales muestran dificultades en el aprendizaje de la matemática en estudiantes indígenas. Dichas dificultades también se han observado en el contexto de la educación intercultural mapuche chilena. Lo anterior podría relacionarse con una falta de compromiso escolar. En esta investigación se busca describir el compromiso escolar en estudiantes mapuche. Se realizó un estudio cualitativo, basado en la fenomenología y etnografía, que incluyó entrevistas y observaciones de clases de dos asignaturas: Beyentun (cosmovisión y espiritualidad mapuche) y Matemáticas. Participaron 10 estudiantes de un liceo ubicado en la región del Biobío (Chile), quienes cursaban primer ciclo de enseñanza secundaria. Los datos se analizaron mediante la técnica de análisis de contenido. Los resultados muestran altos niveles de compromiso. Sin embargo, existen diferencias dentro de las asignaturas: los estudiantes presentan mayores niveles de compromiso emocional en beyentun y mayores niveles de compromiso cognitivo en clases de matemáticas. Asimismo, los resultados muestran una alta promoción de la necesidad de pertenencia y autonomía en las clases de beyentun, mientras que en las de matemática se observa una promoción del desarrollo de la necesidad de competencia. Se discuten estos hallazgos en relación con el compromiso escolar y la educación intercultural.
Activation of Lymphocytes in Healthy Neonates Within Hours of Birth

It is now established that immune maturation occurs along a defined trajectory in the weeks and months after birth, but the immediate changes that occur within immune cells following birth is less clear. In this study, we monitored the immune profile of neonates via analysis of paired samples (n= 28) of cord blood and heel prick blood taken at varying times post term delivery by planned elective caesarean section. This paired approach accounted for the between-subject variability often observed over the first week of life. We identified rapid changes in immune cell populations within hours of birth. Specifically, we observed increased proliferation in effector T cells (but not regulatory T cells) that exhibited an increase in cytokine producing ability and also an increase in the percentage of CD3 T cells over this short time frame. This indicates that the mobilisation of the immune system is immediate post birth, presumably as a response to sudden exposure to the external environment, antigen or stress. Hence, immune development may start to occur more rapidly than previously proposed and as such, to study this trajectory, blood sampling should begin as soon after birth as possible.
Penerapan Rational Emotive Behavior Therapy Teknik Assertif Trainning Untuk Mengatasi Self-Esteem Rendah

Tujuan Penelitian ini adalah 1. Untuk menemukan faktor-faktor yang menyebabkan Self-esteem rendah pada siswa SMK PGRI 1 Mejobo Kudus, 2. Untuk teratasinya Self-Esteem rendah melalui pendekatan Rational Emotive Behavior Therapy teknik Assertif Training pada siswa SMK PGRI 1 Mejobo Kudus. Adapun jenis penelitian yang digunakan adalah penelitian studi kasus dengan pendekatan penelitian kualitatif. Subyek dalam penelitian ini adalah siswa SMK PGRI 1 Mejobo Kudus yang memiliki Self-esteem (harga diri) rendah sebanyak dua siswa (J dan SA). Dalam penelitian ini analisis data dilakukan dengan cara mendeskripsikan hasil dari mengumpulkan data oleh peneliti yaitu pengumpulan data dengan menggunakan metode wawancara, observasi, dokumentasi, dan kunjungan rumah secara mendalam sehingga nantinya mendapatkan data yang akurat terhadap permasalahan yang diteliti yaitu permasalahan tentang Self-esteem rendah. Berdasarkan hasil pembahasan dan analisis penelitian menunjukkan penyebab J dan SA memiliki Self-Esteem rendah disebabkan konseli J mengembangkan pemikiran yang negatif terhadap dirinya sendiri yang merasa lemah karena menjadi bahan bullyan oleh teman-temannya. Konseli SA mengembangkan pemikiran negatif terhadap teman-temannya, merasa minder karena dia berasal dari keluarga yang kurang mampu, sedangkan teman-temannya dari keluarga yang mampu. Untuk mengatasi permasalahan tersebut peneliti menggunakan pendekatan Rational Emotive Behavior Therapy (REBT) teknik Assertif Trainning. Dari hasil konseling kedua siswa tersebut, mereka dapat meningkatkan Self-Esteem dalam kehidupannya. Berdasarkan hasil penelitian tersebut, maka peneliti menyimpulkan bahwa tingkat keberhasilan teknik Assertif Trainning efektif digunakan untuk mengatasi Self-Esteem rendah pada siswa, sehingga siswa berkembang secara optimal. Hal ini dibuktikan adanya perubahan pola pikir maupun perasaan dan perilaku konseli. Konseli mampu meningkatkan Self-Esteem, selain itu terjadi perubahan pola pikir negatif menjadi positif dan perilaku siswa.
Concepts of Innovation for and from Emerging Markets

A closer look at innovation for and from emerging markets respectively developing economies reveals that a variety of different terms and concepts related to this type of innovation exist. The goal of my conceptual paper is to present a comprehensive overview of related terms and concepts and to suggest theoretical based classification criteria in order to differentiate them. After a first investigation in relation to innovation for and from emerging markets the keywords "reverse", "frugal", "jugaad", and "bottom of the pyramid / bottom of pyramid / bop" were identified and used for searching the database of Google Scholar. For further investigation only texts were considered with at least eight various terms. 19 different texts were identified which classified for a further analysis. As results 33 identified terms in relation to innovation for and from emerging markets, various spellings and synonyms and references with at least two mentions in the identified texts are presented. As theoretical based classification criteria "market orientation", "determinants" (of innovation for and from emerging market)", "natur" (of innovation for and from emerging markets), "sophistication", "sustainability", "novelty" and "innovator type" were identified.
Association between Selected Screening Tests and Knee Alignment in Single-Leg Tasks among Young Football Players

This study aimed to examine the relationship between knee valgus in the frontal plane projection angle (FPPA) during single-leg squat (SLS), single-leg landing (SLL), and other selected clinical tests in young athletes. Forty-three young healthy elite football players (age: 13.2 (1.7) years) that were regularly training in a local sports club participated in the study. The FPPA was assessed using 2D video analysis. The screening tests included the passive single-leg raise (PSLR), hip external and internal rotation (hip ER and IR), sit and reach test, weight-bearing lunge test (WBLT), modified star excursion balance test (mSEBT), countermovement jump (CMJ), single-leg hop for distance (SLHD), and age peak height velocity (APHV). There was a significant positive relationship between the knee valgus angles in the SLS test and the sit and reach test (r = 0.34) and a negative relationship with the hip ER ROM (r = −0.34) (p < 0.05). The knee valgus angles in the SLL were negatively associated with the hip IR (r = −0.32) and ER ROM (r = −0.34) and positive associated with the WBLT (r = 0.35) and sit and reach test (r = 0.33) (p < 0.05). Linear regression analysis showed that the results of the hip ER ROM and sit and reach tests were independent predictors of the FPPA in the SLS test (r2 = 0.11, p = 0.03 and r2 = 0.12, p = 0.02, respectively). The conducted study showed that individuals with more hip range of motion, more spine flexion extensibility, and less ankle dorsiflexion ROM may be more likely to experience high degrees of knee valgus in FPPA.
In Vivo Magnetic Resonance Thermometry for Brain and Body Temperature Variations in Canines under General Anesthesia

The core body temperature tends to decrease under general anesthesia. Consequently, monitoring the core body temperature during procedures involving general anesthesia is essential to ensure patient safety. In veterinary medicine, rectal temperature is used as an indicator of the core body temperature, owing to the accuracy and convenience of this approach. Some previous studies involving craniotomy reported differences between the brain and core temperatures under general anesthesia. However, noninvasive imaging techniques are required to ascertain this because invasive brain temperature measurements can cause unintended temperature changes by inserting the temperature sensors into the brain or by performing the surgical operations. In this study, we employed in vivo magnetic resonance thermometry to observe the brain temperatures of patients under general anesthesia using the proton resonance frequency shift method. The rectal temperature was also recorded using a fiber optic thermometer during the MR thermometry to compare with the brain temperature changes. When the rectal temperature decreased by 1.4 ± 0.5 °C (mean ± standard deviation), the brain temperature (white matter) decreased by 4.8 ± 0.5 °C. Furthermore, a difference in the temperature reduction of the different types of brain tissue was observed; the reduction in the temperature of white matter exceeded that of gray matter mainly due to the distribution of blood vessels in the gray matter. We also analyzed and interpreted the core temperature changes with the body conditioning scores of subjects to see how the body weight affected the temperature changes.