Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety and Efficacy of Crizotinib in Combination with Temozolomide and Radiotherapy in Patients with Newly Diagnosed Glioblastoma: Phase Ib GEINO 1402 Trial

Simple Summary Most patients with glioblastoma, the most frequent primary brain tumor in adults, develop resistance to standard first-line treatment combining temozolomide and radiotherapy. Signaling through the hepatocyte growth factor receptor (c-MET) and the midkine (ALK ligand) promotes gliomagenesis and glioma stem cell maintenance, contributing to the resistance of glioma cells to anticancer therapies. This trial reports for the first time that the addition of crizotinib, an ALK, ROS1, and c-MET inhibitor, to standard RT and TMZ is safe and resulted in a promising efficacy for newly diagnosed patients with glioblastoma. Abstract Background: MET-signaling and midkine (ALK ligand) promote glioma cell maintenance and resistance against anticancer therapies. ALK and c-MET inhibition with crizotinib have a preclinical therapeutic rationale to be tested in newly diagnosed GBM. Methods: Eligible patients received crizotinib with standard radiotherapy (RT)/temozolomide (TMZ) followed by maintenance with crizotinib. The primary objective was to determine the recommended phase 2 dose (RP2D) in a 3 + 3 dose escalation (DE) strategy and safety evaluation in the expansion cohort (EC). Secondary objectives included progression-free (PFS) and overall survival (OS) and exploratory biomarker analysis. Results: The study enrolled 38 patients. The median age was 52 years (33–76), 44% were male, 44% were MGMT methylated, and three patients had IDH1/2 mutation. In DE, DLTs were reported in 1/6 in the second cohort (250 mg/QD), declaring 250 mg/QD of crizotinib as the RP2D for the EC. In the EC, 9/25 patients (32%) presented grade ≥3 adverse events. The median follow up was 18.7 months (m) and the median PFS was 10.7 m (95% CI, 7.7–13.8), with a 6 m PFS and 12 m PFS of 71.5% and 38.8%, respectively. At the time of this analysis, 1 died without progression and 24 had progressed. The median OS was 22.6 m (95% CI, 14.1–31.1) with a 24 m OS of 44.5%. Molecular biomarkers showed no correlation with efficacy. Conclusions: The addition of crizotinib to standard RT and TMZ for newly diagnosed GBM was safe and the efficacy was encouraging, warranting prospective validation in an adequately powered, randomized controlled study.
E-Government in Australia: A Usability Study of Australian City Council Websites

The adoption of e-government signifies a positive way to move ahead in the 21st century with enhanced quality, cost effective government services and a superior relationship between different stakeholders. E-government provides new opportunities to both government and its citizens. The wider acceptance of new communication technologies are helping governments and their agencies worldwide to serve citizens, businesses and other governments with greater efficiency. This chapter looks at e-government development statistics globally before narrowing down to Internet usage and e-government adoption in Australia. Opportunities and challenges of e-government adoption are presented. The chapter then focuses on the current state of e-government in Australian city councils and seeks to evaluate council websites to understand their usability characteristics. Seven Australian capital city council websites have been chosen and evaluated based on factors such as navigation, searchability, layout and visual clarity, information content, communication methods, and transactional services. The research indicates that e-government in Australia is in its early stages and there is scope for further improvement and growth. The high incidence of web presence indicates that government entities, such as city councils are pursuing cyber strategies. Although the majority of government entities utilise websites to disseminate information to the public, optimal use of ICT in the public sector is ad hoc and in infancy albeit growing rapidly. This chapter provides a concise and holistic understanding of issues that can be encountered when exploiting the Internet and ICT for providing e-government services. Ritesh Chugh Central Queensland University Melbourne, Australia Srimannarayana Grandhi Central Queensland University Melbourne, Australia
Urine Cell-Free MicroRNAs in Localized Prostate Cancer Patients

Simple Summary Urine cell-free microRNAs (cfmiRs) are promising biomarkers for the detection of prostate cancer (PCa) and may replace or complement prostate-specific antigen screening. This pilot study aims to demonstrate the diagnostic utility of urine cfmiRs for early-stage PCa using a robust microRNA (miR) panel based on next-generation sequencing. We assessed urine, plasma, and formalin-fixed paraffin-embedded tumor tissue samples obtained from patients diagnosed with pT2 PCa. Differentially expressed miRs were found in urine, plasma, and tumor samples obtained from PCa patients. Through bioinformatic analysis, several miRs were found as potential cfmiRs with utility for the detection of PCa. Our results showed that specific cfmiRs in urine samples from PCa patients may have potential utility in the detection of early-stage PCa. Abstract Prostate cancer (PCa) is the most common cancer in men. Prostate-specific antigen screening is recommended for the detection of PCa. However, its specificity is limited. Thus, there is a need to find more reliable biomarkers that allow non-invasive screening for early-stage PCa. This study aims to explore urine microRNAs (miRs) as diagnostic biomarkers for PCa. We assessed cell-free miR (cfmiR) profiles of urine and plasma samples from pre- and post-operative PCa patients (n = 11) and normal healthy donors (16 urine and 24 plasma) using HTG EdgeSeq miRNA Whole Transcriptome Assay based on next-generation sequencing. Furthermore, tumor-related miRs were detected in formalin-fixed paraffin-embedded tumor tissues obtained from patients with localized PCa. Specific cfmiRs signatures were found in urine samples of localized PCa patients using differential expression analysis. Forty-two cfmiRs that were detected were common to urine, plasma, and tumor samples. These urine cfmiRs may have potential utility in diagnosing early-stage PCa and complementing or improving currently available PCa screening assays. Future studies may validate the findings.
Embroidered Ground Planes for Wearable Antennas

Various embroidered structures with differing amounts of stitch spacing, stitch density, and various stitching patterns are characterized through scattering experiments. From the scattering measurements, an effective sheet resistance is determined for a variety of embroidery parameters. Based on observations from the characterization procedure, several hybrid ground planes incorporating both computerized embroidery and metallized fabric are then realized and compared in view of their applications to textile antennas. The main contribution of the current study is then to provide a practical means of realizing selectively embroidered antenna structures that can serve as a viable, if not equivalent, replacement to purely metallized fabric-based antennas.
Optimal Controllers to Improve Transient Recovery of Grid-Following Inverters Connected to Weak Power Grids

Leading to the enormous growth in renewable and power electronics technologies and the global drive towards environmental friendliness and sustainability, a significant number of renewable energy sources are being connected to the power system via inverter-based systems. The inverter-based generations (IBG) have no stored energy and less fault current injection capability compared to the conventional synchronous machines. Consequently, a large penetration of IBG creates challenges to maintaining the stability of the power system, especially the transient stability. The weaker the power system, the higher the significance of instability. Few solutions exist in the literature to improve the fault recovery of IBG connected to weak power systems. This paper considers the method of storing energy in sub-module capacitors of the Modular-Multi-level Converter (MMC) along with temporarily boosting the inverter’s current limit. Conversely, increasing the ratings of the inverter will result in high manufacturing costs. Hence an optimization strategy is proposed in this paper, for obtaining a robust set of inverter control parameters that enhances fault recovery without excessively increasing the manufacturing cost of MMC. A frequency scanning technique supplemented with Generalized Nyquist criteria is incorporated into the optimization methodology to constrain the search space for the optimization algorithm. This enables the optimization algorithm to converge to an acceptable solution with a reasonable computing time. Furthermore, validation of the resultant set of parameters for different system conditions is presented. Finally, IBG with optimized fault recovery controllers is integrated into a simplified real-world power system, and the applicability of the proposed optimized controllers is illustrated.
Total Phenolics and Anthocyanins Contents and Antioxidant Activity in Four Different Aerial Parts of Leafy Sweet Potato (Ipomoea batatas L.)

Leafy sweet potato (Ipomoea batatas L.) is an excellent source of nutritious greens and natural antioxidants, but reports on antioxidants content and activity at buds, leaves, petioles, and stems are scarce. Therefore, the total phenolics content (TPC), total anthocyanins content (TAC), and antioxidant activity (assessed by DPPH and ABTS radical scavenging activities and ferric reducing antioxidant power (FRAP)) were investigated in four aerial parts of 11 leafy sweet potato varieties. The results showed that varieties with pure green aerial parts, independently of the part analyzed, had higher TPC, FRAP, and ABTS radical scavenging activities. The green-purple varieties had a significantly higher TAC, while variety GS-17-22 had the highest TAC in apical buds and leaves, and variety Ziyang in petioles and stems. Among all parts, apical buds presented the highest TPC and antioxidant capacity, followed by leaves, petioles, and stems, while the highest TAC level was detected in leaves. The TPC was positively correlated with ABTS radical scavenging activity and FRAP in all parts studied, whereas the TAC was negatively correlated with DPPH radical scavenging activity. Collectively, the apical buds and leaves of sweet potato had the higher levels of nutritional values. These results would provide reference values for further breeding of leafy sweet potatoes.
Benchmark Simulation Model for Integrated Urban Wastewater Systems: Model Development and Control Strategy Evaluation

The integrated urban wastewater system (UWS) consists of different sections that are interconnected. These include: i) catchment; ii) sewer network; iii) wastewater treatment plant (WWTP); and finally, iv) receiving water system. Traditionally, these sections are operated and evaluated individually. However, it is now well-established that all the sections of an UWS should be operated in a holistic manner in order to improve the receiving water quality. The thesis aims at developing an integrated model library that can be used to simulate the dynamics of flow rate and pollutant loads in all the sections of an UWS on a single simulation platform. It is further aimed at defining a hypothetical UWS using the model library, so that future users can use the pre-defined layout to study multiple control strategies and structural modifications. In order to facilitate an objective evaluation of the results, criteria for evaluating river water quality as well as the sewer network and WWTP performance are described.Firstly, the suitability of existing model libraries is assessed. The building blocks from the Dynamic Influent Pollutant Disturbance Scenario Generator (DIPDSG) are used as the starting point for the catchment and sewer network model library. Additional model blocks that are missing in the DIPDSG are developed. A modified version of the Benchmark Simulation Model No. 2 (BSM2) is used to simulate the WWTP. Model blocks for river water quality assessment are developed. Using the model library, a hypothetical UWS for an urban catchment with 80 000 population equivalents and an area of 540 hectares is described. The UWS layout is used to develop and evaluate different control strategies (local/integrated) and structural modifications. The case studies indicate that: i) the presented model library and the layout can be used to develop various control strategies and evaluate their impact on river water quality; and ii) improving the performance of an individual section does not necessarily lead to better river water quality. It is expected that the model library will be widely used as an open-source software toolbox for benchmarking purposes, integrated modelling studies as well as for modelling the individual sections. (Less)
Analysis of the evolution of the price of oncology drugs after the loss of their patent and the marketing of generic medicines

Background and research question: Loss of exclusivity of oncology drugs causes an important drop in their price due to the marketing of generic medicines. In this article we study how the price of certain oncology drugs evolves throughout time after the loss of their patent, both in terms of the notified price and at a level of the public tenders for the purchase of medicines. Methods: The variation in the price of oral oncology drugs was assessed from the public information provided by the Interministerial Medicinal Products Pricing Committee (Comisión Interministerial de Precios de los Medicamentos, CIPM) and the data from public tenders for the purchase of medicines. Results: The data show a significant drop in price of the medicines assessed after the expiry of their patent, both at a notified price level (70% of average drop in price in 2.6 years) and at the level of the public tenders (drops exceeding 90% in a year for the most innovative drugs). Discussion: The drop in the price of the oncology drugs after the expiry of their patent is seen in all the medicines assessed. The trends seen allow to predict the evolution of the price of another innovative medicine that is nearing the expiry of its patent (Lenalidomide), with an expected drop in price by 90% with respect to the current price of the innovative drug.
Epidemiology of Glioblastoma Multiforme–Literature Review

Simple Summary Glioblastoma multiforme (GBM) is one of the most aggressive malignancies, accounting for 14.5% of all central nervous system tumors and 48.6% of malignant central nervous system tumors. The median overall survival (OS) of GBM patients is only 15 months. The aim of this review was to provide an overview of the epidemiology of GBM and factors that may have a significant impact on the risk of GBM. Abstract Glioblastoma multiforme (GBM) is one of the most aggressive malignancies, with a median overall survival of approximately 15 months. In this review, we analyze the pathogenesis of GBM, as well as epidemiological data, by age, gender, and tumor location. The data indicate that GBM is the higher-grade primary brain tumor and is significantly more common in men. The risk of being diagnosed with glioma increases with age, and median survival remains low, despite medical advances. In addition, it is difficult to determine clearly how GBM is influenced by stimulants, certain medications (e.g., NSAIDs), cell phone use, and exposure to heavy metals.
HUBUNGAN GAYA HIDUP DENGAN TERJADINYA PENYAKIT DIABETES MELITUS DI RSU DAERAH Dr R.M DJOELHAM

Diabetes was a disease caused by disturbances in the absorption of blood sugar by the body, resulting in high levels in the blood. The International Diabetes Federation (IDF) estimated that there were at least 463 million people aged 20-79 years in the world suffering from DM in 2019. This study aimed to determine the relationship between lifestyle and the occurrence of diabetes mellitus. This research is a type of comparative research with a retrospective study design. This research was conducted at RSU Daerah Dr R.M Djoelham and the time of the study was from Augustus-October 2021. The population in this study were all outpatients at the outpatient clinic as many as 143 people and the size of the sample in this study was 40 people. The sampling technique used non-random sampling by accidental sampling. This study uses primary data and secondary data. The results of this study indicate that there is no relationship between diet, exercise and work with diabetes mellitus where the p-value of diet = 0.490 (> 0.05), the p-value of exercise = 0.744 (> 0.05) and the p-value of work = 0.337 (> 0.05), Based on the results of the study, it can be concluded that there is no relationship between lifestyle and the incidence of diabetes mellitus. It is recommended for respondents to continue to strive to increase knowledge about the application of a healthy lifestyle, increase compliance in carrying out treatment therapy programs, and implement a healthy lifestyle.
PVA-Based Electrospun Biomembranes with Hydrolyzed Collagen and Ethanolic Extract of Hypericum perforatum for Potential Use as Wound Dressing: Fabrication and Characterization

Biological, physicochemical, structural, and thermal properties of PVA-based electrospun wound dressings added with hydrolyzed collagen (HC) and different concentrations of Hypericum perforatum ethanolic extract (EEHP) were studied. Membrane characterization was carried out by X-ray diffraction, Fourier infrared spectroscopy, differential scanning calorimetry, barrier properties, scanning electron microscopy, image analysis (diameter and pore size), as well as antimicrobial and anti-inflammatory activities. Results showed that the PVA/HC/EEHP materials, fabricated under controlled conditions of temperature and humidity, generated fiber membranes with diameters between 140–390 nm, adequate porosity and pore size for cell growth (67–90% and 4–16 µm, respectively), and good barrier properties (0.005–0.032 g·m−2 s−1) to be used in the treatment of conditions on the skin, and was even better than some commercial products. Finally, they showed to have anti-inflammatory (>80%), and antimicrobial activity against S. aureus and S. epiderm. Furthermore, higher crystalline structure was observed according to the EEHP concentration. In addition, this is the first report in which PVA/HC/EEHP membranes are successfully fabricated and characterized.
Determinants of Soil Bacterial Diversity in a Black Soil Region in a Large-Scale Area

Soils in black soil areas are high in organic matter and rich in nutrients. Soil microorganisms are particularly critical to cultivated land. The objective of this study was to explore the influencing factors of soil bacterial diversity under special regional conditions in a black soil region. In this study, the cultivated land in a black soil area was used as the study area and a random forest was used to map the bacterial abundance in the black soil area based on 1810 sample points. DbMEM analysis was used to quantify the spatial effect of the black soil area and to identify the influencing factors of soil bacterial abundance in the black soil area in combination with soil properties, terrain, and climate. Results of a variation division showed that broad (8.336%), AT (accumulated temperature, 5.520%), and pH (4.184%) were the main factors affecting soil bacterial diversity. The broad effect was more significant in the spatial effect, which may be related to the local landscape configuration. Overall, our research showed that the influencing factors of soil bacteria will be affected by regional characteristics.
A Narrative literature review on Phytopharmacology of a Caricature Plant: Graptophyllum pictum (L.) Griff. (Syn: Justicia picta Linn.)

Graptophyllum pictum is a plant used in medicine from the time of Ayurveda, the ancient system of Indian medicine. This review article is presented to give an insight on all the updated information on its pharmacological activities. Studies indicated that G. pictum possesses diverse medicinal properties such as anti-inflammatory, nephroprotective, antidiabetic, oxytocic, and anti-implantation properties. This review comprehends the numerous medicinal uses and present literature for pharmacological review of G. pictum belongs to family Acanthaceae.
Blockage of Fibronectin 1 Ameliorates Myocardial Ischemia/Reperfusion Injury in Association with Activation of AMP-LKB1-AMPK Signaling Pathway

Myocardial ischemia/reperfusion injury (I/RI) is closely associated with energy substrate metabolism. Fibronectin 1 (Fn1) was markedly elevated in the heart of I/R pigs and ischemic patients, but its role in myocardial I/RI is controversial and the precise mechanism involved remains elusive. Herein, we tested whether blockage of Fn1 with its inhibitor (fibronectin tetrapeptide, RGDS) would alleviate myocardial I/RI. Wild-type (WT) mice were administered with RGDS once 3 h before I/R operation and once at 24 or 48 h postreperfusion, and sacrificed at 24 or 72 h post-I/R, respectively. Cardiac function was evaluated by echocardiography. Myocardial infarction size, apoptosis, fibrosis, and inflammation were examined via histological staining. Uptake of glucose and fatty acids were detected by positron emission tomography (PET) and computer tomography (CT) with [18F]-2-fluoro-2-deoxy-D-glucose (FDG) and [18F]-fluoro-6-thia-heptadecanoic acid (FTHA), respectively. Our results showed that administration of RGDS to mice remarkably limited the I/R-induced myocardial infarct size, myocyte apoptosis, inflammation, oxidative stress, and fibrosis and improved cardiac contractile dysfunction. These protective effects were associated with upregulation of the AMP/ATP ratio and the activation of LKB1-AMPK signaling, which subsequently increased AS160-GLUT4-mediated glucose and fatty acid uptake, improved mitochondrial dynamic imbalance, and inactivated TGF-β and NF-κB signals in the I/R heart. In conclusion, the current study identified that blocking Fn1 protects against myocardial I/RI likely through activating the LKB1-AMPK-dependent signals and highlights that inhibition of Fn1 may be a novel therapeutic option for treating ischemic heart diseases.
Incidence and Associated Factors of Infantile Colic in Thai Infants

Purpose Infantile colic, a common functional gastrointestinal condition, causes distress and frustration in families. Its prevalence and incidence vary from community to community. The purpose of our study was to demonstrate the incidence of and factors associated with infantile colic in Thai infants. Methods We conducted a prospective analytic study to explore the incidence and factors associated with infantile colic in 386 Thai infants aged between one month and six months. Caregivers were interviewed using a questionnaire about infants’ symptoms of colic based on the definition from the Rome IV criteria. Family background and potential precipitating factors of colic were also evaluated. Results The incidence of colic in infants younger than 6 months was 6.5%. All infants’ colic started within 12 weeks of life and lasted approximately 6 weeks. Sex, gestational age, birth weight, delivery route, birth order, family factors, and parental factors were not correlated with the occurrence of colic. Infants who were exclusively breastfed for the first 2 months of life had a lower incidence of infantile colic than those who were mixed- or formula-fed (odds ratio=3.0; 95% confidence intervals=1.3 to 7.2). Conclusion The incidence of infantile colic in Thai infants in our study was 6.5%, which is similar to that in other reports. Being exclusively breastfed for the first two months was the only risk factor in our cohort.