Miracle-dz/UniFAR-FTUs huggingface dataset:
Brain MRI Volumetry Analysis in an Indonesian Family of SCA 3 Patients: A Case-Based Study

Introduction Spinocerebellar ataxia type-3 (SCA3) is an adult-onset autosomal dominant neurodegenerative disease. It is caused by expanding of CAG repeat in ATXN3 gene that later on would affect brain structures. This brain changes could be evaluated using brain MRI volumetric. However, findings across published brain volumetric studies have been inconsistent. Here, we report MRI brain volumetric analysis in a family of SCA 3 patients, which included pre-symptomatic and symptomatic patients. Methodology The study included affected and unaffected members from a large six-generation family of SCA 3, genetically confirmed using PolyQ/CAG repeat expansion analysis, Sanger sequencing, and PCR. Clinical evaluation was performed using Scale for the Assessment and Rating of Ataxia (SARA). Subjects' brains were scanned using 3.0-T MRI with a 3D T1 BRAVO sequence. Evaluations were performed by 2 independent neuroradiologists. An automated volumetric analysis was performed using FreeSurfer and CERES (for the cerebellum). Result We evaluated 7 subjects from this SCA3 family, including 3 subjects with SCA3 and 4 unaffected subjects. The volumetric evaluation revealed smaller brain volumes (p < 0.05) in the corpus callosum, cerebellar volume of lobules I-II, lobule IV, lobule VIIB and lobule IX; and in cerebellar gray matter volume of lobule IV, and VIIIA; in the pathologic/expanded CAG repeat group (SCA3). Conclusion Brain MRI volumetry of SCA3 subjects showed smaller brain volumes in multiple brain regions including the corpus callosum and gray matter volumes of several cerebellar lobules.
The new green apartheid? Race, capital and logics of enclosure in South Africa’s wildlife economy

In this paper, we explore relations between race, capital and wildlife conservation in the town of Hoedspruit and its surroundings, which has developed into one of the main centres of the lucrative and rapidly growing ‘wildlife economy’ in South Africa. Behind its image as a shining ‘green’ example of wildlife-based development is a highly unequal and racialised state of affairs that is deeply unsustainable. At the core of these dynamics are private wildlife reserves, high-end nature-based tourism and gated ‘wildlife estates’, which have further consolidated land into private, mostly white, ownership. In addition to contestations about the building of a shopping mall and land claims, Hoedspruit’s wildlife economy is dependent upon black labourers who commute daily from former homeland areas. Municipal efforts to mediate this situation by building affordable housing, have been thwarted by several wealthy inhabitants and property developers. We build on Mbembe’s ‘logic of enclosure’ to argue that the wildlife economy and its ‘green’ image perpetuate and reinvent older forms of colonial and apartheid geographies of segregation, in effect creating a form of ‘new green apartheid’. While physical-geographical enclosures are at the centre of the wildlife economy, we show that they are reinforced by class and racial enclosures and ideological enclosures, the latter consisting of both the belief in the market as a natural solution for social and environmental causes and apartheid as an historical era that has now ended. We conclude that Hoedspruit serves as an important example of the regressive and unsustainable forms of development that the wildlife economy in South Africa can create.
The Effect of Type of Delivery on Female Postpartum Sexual Functioning: A Systematic Review

Female sexual function could be considered as multifactorial. Specific physiological structures and hormonal fluctuations postpartum, along with the psychological adjustment of women, could result in altered sexual function. The primary aim of this review was to systematically appraise the existing data on the effect of mode of delivery on female sexual function. This review was designed based on the PRISMA statement guidelines. An extensive literature search was performed in the Pubmed, Scopus, and PsycInfo databases, using prespecified inclusion/exclusion criteria, between the 20 September and 10 October 2021. Studies’ quality assessment was conducted using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies of the National Heart, Lung, and Blood Institute. The initial search involved 1592 studies. The last step of the screening procedure yielded 16 studies, including 41,441 subjects with a mean age of 29.9 years. Studies included groups with spontaneous and assisted vaginal and C-section delivery modes. No statistically significant difference between groups was found. The type of delivery appears to be irrelevant regarding this relationship. Moderating factors seemed to indirectly influence this relationship. Health professionals should educate expectant mothers and be aware of the possibility that delivery method could affect sexual function.
The impact of electronic monitoring on fleet wide discarding of small cod in Scottish demersal fisheries

In Europe, uptake of electronic monitoring (EM) has been hindered by a lack of potential cost savings, given low existing observer coverage, and resistance from industry to greater enforcement of the landing obligation. To assess why certain vessels volunteer for EM and what their subsequent changes in behaviour tell us about those of the wider fleet over time, this study investigates effects of EM on discarding of North Sea cod by Scottish demersal trawlers. As discard data were limited, weight of small cod (grade 5) landed per trip was selected as an indicator of discarding and modelled to describe discard patterns from 2006 to 2016 encompassing the EM-verified cod quota management scheme (2010–2016). Findings show that EM leads to reduced instances of discarding of small cod by participants. However, evidence suggests non-participant vessels were driven to greater levels of discarding due to quota acquisition by participants. Vessels volunteering for EM trials were not predisposed towards greater compliance. Landings data do not support the trial objective of incentivising avoidance of small cod being met. The influence of participants on non-participants has implications for how vessels are selected, and management of behavioural adaptions required to ensure participants remain representative of the wider fleet.
Simple FCS-MPC Method for Reducing Common-Mode Voltage in a Three-Phase Two-Level Voltage Source Inverter

Common mode voltage (CMV) causes various issues, including a negative impact on the performance of a hybrid electric vehicle’s power system (HEV). Many papers have published methods that mitigate CMV, almost all of which attempt to avoid zero vectors, but this increases total harmonic distortion (THD). This work describes a simple and efficient method for reducing CMV in a two-level three-phase voltage source inverter (VSI) with an RL load. This method uses only active vectors. It replace the zero vector with the two opposite vectors V2 and V5. for T1 and T2 respectively in a one sampling period Ts. A numerical simulation, using Matlab-Simulink. is achieved to assess the effectiveness of the proposed control technique. The obtained results show a reduction in THD value (17% improvement) and a decrease in the peak value of CMV from (${{ + {V_{dc}}} \over 2}$ and ${{ - {V_{dc}}} \over 6}$) to $\pm {{{V_{dc}}} \over 6}$. These results are compared to those obtained by using the traditional predictive control model MPC.
Question Answering over Knowledge Graphs: A Case Study in Tourism

Over the recent years, a large number of knowledge graphs (KGs) have been developed to store and present small and medium enterprises’ data in the form of subject-predicate-object triples. The KGs are not easily accessible to end-users because they need an understanding of query languages and KGs’ structures. To assist end-users in accessing these KGs, question answering over KGs targets to provide answers for natural language questions (NLQs). This paper proposes an approach to answer questions over small and medium scaled KGs based on graph isomorphism in two phases: (1) offline phase and (2) semantic parsing phase. In the offline phase, a semi-automated solution is proposed to generate NLQs and their answers, which are used to train machine learning models employed in the next phase. In the semantic parsing phase, a given input NLQ is mapped into a query pattern according to its grammatical structure. Each query pattern contains some slots that need to be filled with corresponding entities, classes and relations from the KG. While string and semantic similarity metrics are applied to identify the entities and classes, the probability distribution of the relations is used to extract the relations. The Cartesian product of the identified entities, classes and relations is utilized to fill the slots, derive SPARQL queries and finally retrieve the answers. To evaluate the proposed approach, we use SalzburgerLand KG, a real KG describing touristic entities of the region of Salzburg, Austria. Our results show that the approach improves the end-to-end user experience in terms of interactive question answering and performance.
Community-based multidisciplinary joint injection clinic.

Over 30% of all general practice (GP) consultations are due to musculoskeletal complaints (Department of Health, 2006). Currently, the present system relies predominantly on referral to secondary care in hospitals for most conditions. Patients are either treated by their GP or referred to physiotherapy, podiatry, orthopaedics, orthotics or rheumatology services. However, access to these specialist services is difficult in some areas, and can result in long waiting times. As a result, patients endure undue pain, ill health and time off work while awaitingmanagement of their complaints. In some cases, there is little management before a patient is seen in a consultant clinic, which can take up to 12weeks. Patients demand high-quality, prompt treatment and advice to stay healthy and remain independent. Using the ‘Musculoskeletal Framework’ published by the Department of Health as a foundation (Department of Health, 2006), we set up a multidisciplinary clinic within a local population to try to improve access to specialist services and reduce waiting times for those with musculoskeletal complaints.
Robust Task Scheduling for Delay-Aware IoT Applications in Civil Aircraft-Augmented SAGIN

Although 5G networks have enabled mobile users to get a better experience, task scheduling remains challenging for massive Internet of Things (IoT) devices in remote areas. This paper investigates the task scheduling problem for delay-aware IoT applications in civil aircraft-augmented space-air-ground integrated networks (CAA-SAGIN), where the normalized sky access platforms (SAPs) can collect and forward the terrestrial tasks. Specifically, we first propose an access control scheme for a non-preemptive priority queuing system and a transmission control scheme with cross-layer optimization. Secondly, considering the uncertain distribution of the transmission numbers and generated data, we formulate a robust two-stage stochastic optimization problem of delay minimization. With the proposed robust task scheduling with risk aversion (RTS-RA) algorithm, the original problem can be decomposed into two subproblems, which can be further transformed into tractable semi-definite program (SDP) problems respectively. Simulation results show that the cross-layer optimization scheme can achieve a good tradeoff between delay and throughput. Also, the RTS-RA algorithm outperforms the exiting offloading schemes in terms of end-to-end delay, transmitted data, and energy consumption with lower computational complexity.
Spectrum Sharing under Interference Constraints

In this thesis, we address the problem of spectrum-sharing for wireless communication where multiple users attempt to access a common spectrum resource under mutual interference constraints. Our objective is to evaluate the gains of sharing by investigating different scenarios of spectrum access. Studying the Gaussian Interference Channel with interferences considered as noise, we found a geometrical description and several characteristics of the achievable rate region. Considering a more realistic scenario, with each user having a certain QoS, we found necessary and sufficient condition to be fulfilled for simultaneous communications over the two-user Gaussian Interference Channel. Furthermore, we proposed two lower bounds for a single-primary-user mean rate, depending on the secondary user power control scheme. Specially, we investigated an original power control policy, for a secondary user, under outage performance requirement for both users and partial knowledge of the channel state information. Finally, considering a spectrumsharing with a licensee or primary user and several secondary or cognitive users, we showed the existence of an exclusive region around the primary receiver and we characterized the effects of shadowing and path-loss on this exclusive region (or no-talk zone).
Redesigning global supply chains during compounding geopolitical disruptions: the role of supply chain logics

PurposeWhy do managers redesign global supply chains in a particular manner when faced with compounding geopolitical disruptions? In answering this research question, this study identifies a constrained system of reasoning (decision-making logic) employed by managers when they redesign their supply chains in situations of heightened uncertainty.Design/methodology/approachThe authors conducted 40 elite interviews with senior supply chain executives in 28 companies across nine industries from November 2019 to June 2020, when the UK was preparing to leave the European Union, the US–China trade war was escalating, and Covid-19 was spreading rapidly around the globe.FindingsWhen redesigning global supply chains, the authors find that managerial decision-making logic is constrained by three distinct environmental ecosystem conditions: (1) the perceived intensity of institutional pressures; (2) the relative mobility of suppliers and supply chain assets; and (3) the perceived severity of the potential disruption risk. Intense government pressure and persistent geopolitical risk tend to impact firms in the same industry, resulting in similar approaches to decision-making regarding supply chain design. However, where suppliers are relatively immobile and supply chain assets are relatively fixed, a dominant logic is consistently present.Originality/valueBuilding on an institutional logics perspective, this study finds that managerial decision-making under heightened uncertainty is not solely guided by institutional pressures but also by perceptions of the severity of risk related to potential supply chain disruption and the immobility of supply chain assets. These findings support the theoretical development of a novel construct that the authors term ‘supply chain logics’. Finally, this study provides a decision-making framework for Senior Executives competing in an increasingly complex and unstable business environment.
Effect of Temperature and Light Intensity on the Polar Lipidome of Endophytic Brown Algae Streblonema corymbiferum and Streblonema sp. In Vitro

The effect of temperature and light intensity on the polar lipidome of endophytic brown algae Streblonema corymbiferum and Streblonema sp. in vitro was investigated. More than 460 molecular species have been identified in four glycoglycerolipids classes, five phosphoglycerolipids classes and one betaine lipid class. The lipids glucuronosyldiacylglycerol and diacylglyceryl-N,N,N-trimethyl-homoserine were found in the algae of the order Ectocarpales for the first time. A decrease in cultivation temperature led to an increase in the unsaturation level in all classes of polar lipids. Thus, at low temperatures, the content of 18:4/18:4 monogalactosyldiacylglycerol (MGDG), 20:5/18:4 digalactosyldiacylglycerol (DGDG), 18:3/16:0 sulfoquinovosyldiacylglycerol (SQDG), 18:3/18:3 and 18:3/18:4 phosphatidylglycerol (PG), 20:4/20:5 and 20:5/20:5 phosphatidylethanolamine (PE), 14:0/20:5, 16:0/20:5 and 20:5/20:5 phosphatidylcholine (PC), 20:5/20:4 phosphatidylhydroxyethylglycine and 18:1/18:2 DGTS increased. At high temperatures, an increase in the content of chloroplast-derived MGDG, DGDG and PG was observed. Both low and high light intensities caused an increase in 20:5/18:3 MGDG and 18:3/16:1 PG. At low light intensity, the content of DGDG with fatty acid (FA) 18:3 increased, and at high light intensity, it was with FA 20:5. The molecular species composition of extraplastid lipids also showed a dependence on light intensity. Thus, the content of PC and PE species with C20-polyunsaturated FA at both sn-positions, 18:1/18:1 DGTS and 16:0/18:1 phosphatidylinositol increased. Low light intensity induced a significant increase in the content of chloroplast-derived 18:1/16:1 phosphatidylethanolamine.
Triple Coupled Ring‐Core Fiber with Dual Highly Dispersive Windows for Orbital Angular Momentum Mode

Orbital angular momentum (OAM) beams, featured by the helical phase front and doughnut intensity profile, have been demonstrating great potential for various applications. Ring‐core optical fiber is also experimentally proven to be an effective waveguide for OAM mode. In general, managing the chromatic dispersion in the optical fiber is important for a wide range of applications. In this article, a highly dispersive germanium‐doped ring‐core fiber with dual selectable operating windows for OAM mode is proposed. The proposed fiber consists of three concentric high‐refractive‐index germanium‐doped rings with different mole fractions. The chromatic dispersion of the OAM1,1 mode in the ring fiber can be as low as −129 964 ps/(nm·km) at 1644.4 nm as the light launches into the fiber from the innermost ring and −270 017 ps/(nm·km) at 1651 nm as the light enters from the outermost ring. Furthermore, the effect of the geometrical and material parameters on chromatic dispersion for OAM1,1 mode is investigated. When the parameters of the innermost and outermost rings are varied separately, the corresponding operation windows are changed independently. An extremely negative dispersion for the OAM1,1 mode of −817 576 ps/(nm·km) can be achieved. This design can serve as a dispersive element in various OAM‐based optical fiber systems.
The Importance of Family Resilience in the Middle of the Covid-19 Pandemic

During the Covid-19 pandemic, studies on Family Resilience are significant because every family has its own challenges in dealing with the pandemic and is required to be able to adapt, overcome, and rise from the various difficulties and challenges. Especially in families with early- age children, family resilience is needed to prevent children from growing up in traumatic situations that can cause hardships in their developmental process. The purpose of this literature- based study is to investigate the literature on Family Resilience in families with early- age children. The data collection and analysis were carried out qualitatively by reading, reviewing, and quoting relevant ideas from relevant journals. The results of the study showed that giving meaning to the difficulties that occur, positive thinking, and spiritualization are three essential areas in building family resilience and can be involved in the family's responses to the Covid-19 pandemic by considering the development of children.
Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi’s Sarcoma

Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human gammaherpesvirus 8 (HHV-8), contains oncogenes and proteins that modulate various cellular functions, including proliferation, differentiation, survival, and apoptosis, and is integral to KSHV infection and oncogenicity. In this review, we describe the most important KSHV genes [ORF 73 (LANA), ORF 72 (vCyclin), ORF 71 or ORFK13 (vFLIP), ORF 74 (vGPCR), ORF 16 (vBcl-2), ORF K2 (vIL-6), ORF K9 (vIRF 1)/ORF K10.5, ORF K10.6 (vIRF 3), ORF K1 (K1), ORF K15 (K15), and ORF 36 (vPK)] that have the potential to induce malignant phenotypic characteristics of Kaposi’s sarcoma. These oncogenes can be explored in prospective studies as future therapeutic targets of Kaposi’s sarcoma.
The Formation Mechanism of Impulse Buying in Short Video Scenario: Perspectives From Presence and Customer Inspiration

It has been found in many cases that consumers are prone to exhibit impulsive buying behavior that is manifested as being immediate, emotional, and irresponsible especially under short video scenario. Supported by the customer inspiration theory, this study explores the psychological mechanism underlying impulse purchase in short videos that differentiates the traditional web shopping by the strong sense of presence in short video marketing. On the basis of a questionnaire survey and three laboratory experiments, this study examines the relationship among presence, customer inspiration, and impulse purchase intention. The empirical results point to the fact that social presence, co-presence, and physical presence have significant positive effects on impulse purchase intention, and customer inspiration mediates the effect of social presence, physical presence, and co-presence on impulse purchase intention. Furthermore, it is indicated that social and co-presence have stronger influences on impulse purchase intention than physical presence, thus proving a stronger effect of social factors on impulse purchase intention than physical factors in short video environment. The research results testify the impact of presence on consumer behavior in the upgrading short video marketing and provide valuable reference for marketing strategies to shorten consumers' decision-making time in short video purchase.
Unlocking Blockchain: Embracing New Technologies to Drive Efficiency and Empower the Citizen

With their innovative and fundamentally liberalising approach to data storage, distributive ledger technologies (DLTs) like blockchain—and other associated technologies offer immense benefits to both the public and private sectors, not least in terms of upping efficiency. Lovers of freedom should also note, however, that they offer an important chance to empower individuals in their necessary engagements with the state, and to rebuild societal trust for the common good. In this paper, we propose the establishment of a UK-based international blockchain competition, and a public-facing **‘Chief Blockchain Officer. ’** We also propose a UK **‘blockchain departmental target’**: a long-term aim for government departments to make a 1% efficiency saving by embracing blockchain and other associated innovative technologies. A renewed UK focus on efficiency and the opportunities of new technology would be inspirational, and we look forward to discussing these proposals, and carrying out further research into Distributed Ledger Technologies.