Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of chidamide in the treatment of B-cell non-Hodgkin lymphoma: An updated systematic review

B-cell non-Hodgkin lymphoma (B-NHL) is a lymphoid malignancy derived from B-cells that remains difficult to treat. Moreover, relapses and refractory cases are common. Abnormalities in epigenetic mechanisms, such as imbalanced histone acetylation affecting certain genes, contribute to relapses and refractory cases. Chidamide (tucidinostat) is a novel histone deacetylase inhibitor that can reverse this epigenetic imbalance and has been approved for the treatment of T-cell malignancies. However, the use of chidamide for B-NHL remains limited, and the lack of relevant literature exacerbates this limitation. We conducted this review to summarize the anticancer activity of chidamide against B-NHL and its clinical applications to overcome drug resistance. This systematic review was conducted according to the PRISMA 2020 guidelines, using some keyword combinations from MEDLINE and EBSCO. The inclusion and exclusion criteria were also defined. Of the 131 records retrieved from databases, 16 were included in the review. Nine articles revealed that chidamide limited tumor progression by modifying the tumor microenvironment, stopping the cell cycle, inducing apoptosis and autophagy, and enhancing complement-dependent and antibody-dependent cell-mediated cytotoxicities. According to seven other studies, administering chidamide in combination with another existing therapeutic regimen may benefit not only patients with relapsed/refractory B-NHL but also those with newly diagnosed B-NHL. Chidamide plays many important roles in limiting B-NHL progression through epigenetic modifications. Thus, combining chidamide with other anticancer drugs may be more beneficial for patients with newly diagnosed and relapsed/refractory B-NHL.
The utility of additional soundings for forecasting lake-effect snow in the Great Lakes region

Abstract The impact of initializing a mesoscale model with additional sounding data over the Great Lakes region is investigated. As part of the Lake-Induced Convection Experiment (Lake-ICE) field study during the winter of 1997/98, six supplementary Cross-chain Loran Atmospheric Sounding System (CLASS) units and three Integrated Sounding System (ISS) units were used in addition to those from the standard synoptic upper-air network. The three ISS units were in the vicinity of Lake Michigan, and the six CLASS units were in the data-sparse region of central and northeastern Ontario and western Quebec. The Pennsylvania State University–National Center for Atmospheric Research fifth-generation Mesoscale Model running on a doubly nested grid is used to simulate the lake-effect snow event of 4–5 December 1997. This model output from a 30-km horizontal resolution grid shows that the six CLASS soundings capture a warm layer below 850 hPa that appears to be the result of diabatic heating from the Great Lakes. This .
Effects of Dietary Intervention Using Spirulina at Graded Levels on Productive Performance and Physiological Status of Quail Birds Reared under Elevated Temperatures

The current study aimed to explore the effect of Spirulina platensis (SP) inclusion at various levels in quail diets, in terms of their production performance, physiological traits, stress measurements, and immunological parameters under heat stress (HS) conditions. Four hundred Japanese quail (Coturnix japonica) chicks, one day old, were equally distributed into forty wire cages, and the cages were placed in two chambers with environmentally controlled systems (20 cages in each chamber). From 21 to 42 d of age, the quails were randomly subjected to a factorial design of two HS treatments × four SP treatments. To induce HS treatments in the quails, the first chamber was maintained at a thermoneutral temperature of 24 °C (TN group), while the temperature of the second chamber was elevated to 35 °C during the daytime (9:00–17:00 h), followed by a thermoneutral temperature for the remaining 24 h cycle (HS group). The birds in each chamber were further allocated into four SP treatments (5 replicate cages × 10 birds per cage in each treatment), where the quails were fed on a basal diet that included 0, 5, 10, or 15 g/kg SP (SP0, SP5, SP10, and SP15 groups, respectively). After exposure to the HS, a significant (p < 0.05) reduction of 5% in body weight and 9% in both weight gain and feed intake was recorded, and the slaughter performance of the quails was adversely (p < 0.05) affected. In addition, HS significantly (p < 0.05) impaired the physiological traits (total protein, albumin, globulin, alanine transferase, aspartate transferase, creatinine, uric acid, cholesterol, and triglycerides) and immunological parameters (total white blood cells, heterophil to lymphocyte ratio, and T- and B-lymphocyte stimulation indexes), but increased the stress measurements (corticosterone, malondialdehyde, interleukin-1β, and tumor necrosis factor-α). In contrast, most of these parameters were linearly (p < 0.05) improved by increasing the SP levels in the diets of the TN quail group. When the SP was included in the diets of the HS quail group, the deleterious effects of HS on the alanine and aspartate transferase activities, creatinine, uric acid, triglycerides, corticosterone, interleukin-1β, and tumor necrosis factor-α levels, heterophil to lymphocyte ratio, and T- and B-lymphocyte stimulation indexes were remarkably (p < 0.05) relieved. These results concluded that SP nutritional application can improve the production performance and the overall physiological homeostasis of the Japanese quail, especially when suffering from heat stress.
The Role of SCL Isoforms in Embryonic Hematopoiesis

Three waves of hematopoiesis occur in the mouse embryo. The primitive hematopoiesis appears as blood islands in the extra embryonic yolk sac at E7.5. The extra embryonic pro-definitive hematopoiesis launches in late E8 and the embryonic definitive one turns on at E10.5 indicated by the emergence of hemogenic endothelial cells on the inner wall of the extra embryonic arteries and the embryonic aorta. To study the roles of SCL protein isoforms in murine hematopoiesis, the SCL-large (SCL-L) isoform was selectively destroyed with the remaining SCL-small (SCL-S) isoform intact. It was demonstrated that SCL-S was specifically expressed in the hemogenic endothelial cells (HECs) and SCL-L was only detected in the dispersed cells after budding from HECs. The SCLΔ/Δ homozygous mutant embryos only survived to E10.5 with normal extra embryonic vessels and red blood cells. In wild-type mouse embryos, a layer of neatly aligned CD34+ and CD43+ cells appeared on the endothelial wall of the aorta of the E10.5 fetus. However, the cells at the same site expressed CD31 rather than CD34 and/or CD43 in the E10.5 SCLΔ/Δ embryo, indicating that only the endothelial lineage was developed. These results reveal that the SCL-S is sufficient to sustain the primitive hematopoiesis and SCL-L is necessary to launch the definitive hematopoiesis.
Assessing causality among topics and sentiments: The case of the G20 discussion on Twitter

Although the identification of topics and sentiments from social media content has attracted substantial research, little work has been carried out on the extraction of causal relationships among those topics and sentiments. This article proposes a methodology aimed at building a causal graph where nodes represent topics and emotions extracted from social media users’ posts. To illustrate the proposed methodology, we collected a large multi-year dataset of tweets related to different editions of the G20 summit, which was locally indexed for further analysis. Topic-relevant queries are crafted from phrases extracted by experts from G20 output documents on four main recurring topics, namely government, society, environment and health and economics. Subsequently, sentiments are identified on the retrieved tweets using a lexicon based on Plutchik’s wheel of emotions. Finally, a causality test that uses stochastic dominance is applied to build a causal graph among topics and emotions by exploiting the asymmetries of explaining a variable from other variables. The applied causality discovery process relies on observational data only and does not require any assumptions of linearity, parametric definitions or temporal precedence. In our analysis, we observe that although the time series of topics and emotions always show high correlation coefficients, stochastic causality provides a means to tell apart causal relationships from other forms of associations. The proposed methodology can be applied to better understand social behaviour on social media, offering support to decision and policy making and their communication by government leaders.
A Bayesian inference for the extended skew-normal measurement error model

In this paper, we introduce the multivariate skew-normal model in the context of measurement error models in order to avoid data transformations or usual constraints on the parametric space. This distribu- tion was recently discussed by Capitanio, Azzalini and Stanghellini (2003) using graphical models. The motivation is to use the conditioning argument on the unobserved true value of the explanatory variable in the two-variable measurement error model in order to get the skewness parameters as a func- tion the original parameters of the proposed measurement error models. In- ferential problems are considered from the Bayesian point of view assuming proper noninformative priors via Winbugs. The usefulness of the proposed model with errors in variables is investigated with a simulation study and real data analysis. The main advantage of the Bayesian approach is the possibility to measure the degree of belief that the true value of the explanatory variable is greater than its mean value. This constraint implies a strong asymmetry on the distribution of the unobserved true value. We end the paper by con- cluding that the extended skew-normal measurement error model provides flexibility in terms of skewness without making any additional assumptions to eliminate the usual identifiable problems in the measurement error models.
Coincidence and covariance data acquisition in photoelectron and -ion spectroscopy. II. Analysis and applications

Abstract We use an analytical theory of noisy Poisson processes, developed in the preceding companion publication, to compare coincidence and covariance measurement approaches in photoelectron and -ion spectroscopy. For non-unit detection efficiencies, coincidence data acquisition (DAQ) suffers from false coincidences. The rate of false coincidences grows quadratically with the rate of elementary ionization events. To minimize false coincidences for rare event outcomes, very low event rates may hence be required. Coincidence measurements exhibit high tolerance to noise introduced by unstable experimental conditions. Covariance DAQ on the other hand is free of systematic errors as long as stable experimental conditions are maintained. In the presence of noise, all channels in a covariance measurement become correlated. Under favourable conditions, covariance DAQ may allow orders of magnitude reduction in measurement times. Finally, we use experimental data for strong-field ionization of 1,3-butadiene to illustrate how fluctuations in experimental conditions can contaminate a covariance measurement, and how such contamination can be detected.
On actions of reductive groups with one-parameter family

Actions of reductive groups on normal algebraic varieties with one-parameter families of spherical orbits of maximal dimension are studied under the assumption that the categorical quotient for the action is one-dimensional. As an application, the classification of the actions of the group on three-dimensional normal affine varieties is completed. The ground field is assumed to be algebraically closed and of characteristic zero.
A MULTIVARIATE TWO-SAMPLE TEST BASED ON THE NUMBER OF NEAREST NEIGHBOR TYPE COINCIDENCES

Pour des echantillons aleatoires independants: X 1 X 2 …X n1 distribue selon f(x) et Y 1 Y 2 …Y n2 distribue selon g(x) on presente un test qui possede les proprietes suivantes: la probabilite d'erreur de premiere espece ne depend pas de f; lorsque min (n 1 , n 2 )→∞, la statistique de test est asymptotiquement independante de la distribution sous Ho et la distribution limite est connue; le test est consistant contre des alternatives generales
OpenQuake Engine: An Open Hazard (and Risk) Software for the Global Earthquake Model

Since its inception in the 1960s, probabilistic seismic‐hazard analysis (PSHA) (Cornell, 1968; McGuire, 2004, 2008) has emerged as the principal methodology for assessing the potential hazard posed by earthquake ground motion in a broad range of contexts. Seismic‐hazard analysis serves different needs coming from a wide spectrum of users and applications. These may encompass engineering design, assessment of earthquake risk to portfolios of assets within the insurance and reinsurance sectors, engineering seismological research, and effective mitigation via public policy in the form of urban zoning and building design code formulation. End users of seismic‐hazard analyses from different sectors of industry may often have specific requirements in terms of the types of results and, as a consequence, in terms of the methodologies preferred for calculation. A large majority of studies for the analysis of structural and geotechnical systems require the calculation of a target response spectrum derived from PSHA results (e.g., Lin et al. , 2013). Often the calculation of uniform hazard spectra is performed in conjunction with a disaggregation analysis, which in the simplest cases highlights the combinations of magnitude and distances, providing the largest contributions to a specific level of hazard for a particular intensity measure type, such as the spectral acceleration for a period close to the fundamental elastic period of a structure (Bazzurro and Cornell, 1999; Pagani and Marcellini, 2007). In contrast, in the insurance sector it is more common to use stochastic methodologies (e.g., Weatherill and Burton, 2010; Musson, 2012) to produce multiple realizations of the likely earthquake activity that may be pertinent to a portfolio of assets. Monte Carlo–based methods can provide results in a form that offers a practical comparison with past events and can better account for the temporal and spatial variability of earthquake shaking occurring on a distributed set …
Theory and Numerical Simulation of Thermochemical Ablation

The goal of this investigation is to develop and implement a numerical simulation model to predict the outcome of the thermochemical ablation therapy of tumors and other dysfunctional tissue. The simulation model formulated here includes a reaction zone whose volume is defined by the volume of the chemical reagents and a surrounding volume of tissue to be necrosed. Account is taken of the relevant macroscopic thermal processes of conduction, perfusion, metabolism, and internal energy storage/depletion. The zone of necrosed tissue is quantified by means of the Henriques-Moritz thermal damage integral. The simulation model was confirmed by comparisons with available experimental data. The main results extracted from the simulations are the temporal and spatial temperature variations throughout the tissue bed and the resulting distributions of necrosed and non-necrosed tissue. The radius of the zone of necrosis was algebraically correlated with the heat of reaction of the participating reagents. It was demonstrated that through the selection of appropriate conditions, sufficient thermal energy can be released to ablate significant volumes of tissue. The duration of the treatment required to achieve a pre-selected zone of necrosed tissue can also be predicted.
Some results for repairable systems with general repair

In this paper, we develop general repair models for a repairable system by using the idea of the virtual age process of the system. If the system has the virtual age Vn – 1 = y immediately after the (n – l)th repair, the nth failure-time Xn is assumed to have the survival function where is the survival function of the failure-time of a new system. A general repair is represented as a sequence of random variables An taking a value between 0 and 1, where An denotes the degree of the nth repair. For the extremal values 0 and 1, An = 1 means a minimal repair and An= 0 a perfect repair. Two models are constructed depending on how the repair affects the virtual age process: Vn = Vn – 1 + AnXn as Model 1 and Vn = An (Vn – 1 + Xn ) as Model II. Various monotonicity properties of the process with respect to stochastic orderings of general repairs are obtained. Using a result, an upper bound for E[Sn ] when a general repair is used is derived.
Parkinson Hastalığında Motor İmgeleme ve Eylem Gözleminin Yürüme, Denge ve Donma Fenomeni Üzerine Etkisi- Literatür Derlemesi

Parkinson Hastalığı (PH) sonucu ortaya çıkan yürüme ve denge bozuklukları, motor donma atakları düşme riskini arttırarak fonksiyonel bağımsızlığın ve yaşam kalitesinin azalmasına neden olmaktadır. Motor İmgeleme (Mİ) ve Eylem Gözlemi (EG) stratejileri son yıllarda Parkinson Hastalarının fizyoterapi ve rehabilitasyon girişimleri içinde sıklıkla kullanılan yöntemlerdir. Bu derlemenin amacı; PH rehabilitasyonunda donma fenomeni, yürüme ve denge bozukluklarının azaltılması amacıyla kullanılan Motor İmgeleme (Mİ) ve Eylem Gözlemi (EG) stratejilerinin etkinliğini araştıran klinik araştırmaların sonuçlarını incelemekti. Bu amaçla 2000-2021 yılları arasında PH rehabilitasyonunda Mİ ve EG stratejilerine yer veren randomize kontrollü çalışmalar ele alındı. Literatür taraması Medline (PubMed), Physiotherapy Evidence Database (PEDro), Web of Science ve Cochrane veri tabanlarında gerçekleştirildi. Literatür taraması sonucu 9 çalışmanın (n=267) dahil edilme kriterlerini sağladığı tespit edildi. Bu çalışmaların 4 tanesinde Mİ stratejisi, 4 tanesinde EG stratejisi tek başına kullanılırken; 1 tanesinde ise her iki stratejinin beraber uygulandığı görüldü. Çalışmalarda uygulanan tedavilerin süresi 8 gün-12 hafta arasında idi. Sonuç olarak; Parkinson hastalarında EG ve Mİ stratejilerinin egzersiz uygulamalarına ek olarak kullanıldığında yürüyüş ve mobilite üzerinde olumlu etkisi olduğu gözlemlendi. Donma fenomeni ve denge performansını iyileştirmeyi amaçlayan çalışmaların sonuçları ise çelişkiliydi. Bu çalışmaların bir kısmında olumlu etkiler bildirilmiş olsa da kesin bir yargıya varmak için çalışmaların sayısı yetersizdi. Bu nedenle, Mİ ve EG stratejilerinin özellikle donma fenomeni ve denge performansı üzerine etkilerini araştıran daha fazla çalışmaya ihtiyaç duyulmaktadır.
Weak-interaction models with new quarks and right-handed currents

We discuss various weak-interaction issues for a general class of models within the SU(2) x U(1) gauge-theory framework, with special emphasis on the effects of right-handed charged currents and of quarks bearing new quantum numbers. In particular we consider the restrictions on model building which are imposed by the small K/sub L/--K/sub S/ mass difference and by the $delta$I = 1/2 rule, and we classify various possibilities for neutral current interactions and, in the case of heavy mesons with new quantum numbers, various possibilities for mixing effects analogous to K/sub L/--K/sub S/ mixing. (AIP)
Ab initio modelling of K-alpha X-ray spectra in single walled carbon nanotubes

New technologies are currently being developed that require the alignment of carbon nanotube arrays. However, the measurement of carbon nanotube alignment is difficult, especially with micron spatial resolution. Here we consider the use of soft X-ray spectroscopy to measure alignment and we present theoretical electronic density of states (DOS) calculations which show this is possible. To verify the DOS calculations we compare the predicted DOS of graphite and C60 with experimentally measured carbon K,, spectra. In addition we examine a range of electron exchange and correlation functionals to find the optimal one for predicting soft X-ray peak shape and position.
Ultraviolet Radiation Protection by Clothing: Comparison of In vivo and In vitro Measurements

The protection provided by clothing against solar ultraviolet radiation (UVR) has been the subject of considerable recent research. In general, rated clothing is tested according to standards using laboratory based in vitro measurements of the fabric spectral UVR transmittance and weighting this with the erythemal effectiveness of the CIE (1987) to determine an Ultraviolet Protection Factor (UPF). While in vitro test methods provide a precise determination of protection, there were some concerns they could overestimate the protection in comparison to in vivo measurements. This paper details a comparison of UPFs derived from the in vitro tests for 16 fabric samples against in vivo SPF tests. Agreement between the two sets of results is very good, with no statistically significant difference between the two data sets and with only one misclassification of protection category between the SPFs and UPFs.
A generalized global differential calculus : application to invariance under a Lie group. I

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Divided We Unite: The Nature of Partyism and the Role of Coalition Partnership in Europe

ighlighting the strength of “ partyism ” in many democracies, recent scholarship pays keen attention to increasing hostility and distrust among citizens across party lines, known as affective polarization. By combining a conjoint analysis with decision-making games such as dictator and trust games, we design a novel survey experiment to systematically estimate and compare the strength of the partisan divide relative to other social divides across 25 European democracies. This design also allows us to investigate how the two components of affective polarization, in-group favoritism and out-group derogation, are moderated by the way parties interact with each other. We first find dominance of the partisan divide compared to other social divides that constitute traditional cleavages such as social class and religion. Second, we show that affective polarization in Europe is not primarily driven by out-group animus. Finally, we demonstrate that coalition partnership lessens affective polarization by reducing both in-group and out-group biases.
Polyhedral Realizations of Crystal Bases for Modified Quantum Algebras of Rank 2

We describe the crystal bases of the modified quantum algebras and give the explicit form of the highest (or lowest) weight vector of its connected component B 0(λ) containing the unit element for arbitrary rank 2 cases. We also present the explicit form of B 0(λ) containing the highest (or lowest) weight vector by the polyhedral realization method.
Estado actual del tratamiento del Hallux Rigidus: nuestra propuesta de algoritmo terapéutico

Se define hallux rigidus como la afectación de la primera articulación metatarsofalángica (MTF) y del complejo sesamoideo caracterizada por dolor, restricción de la movilidad y osteofitosis periarticular (1). Constituye la 2a patología más frecuente en la primera articulación MTF tras el hallux valgus y es la artrosis más frecuente del pie y tobillo (2). Es más frecuente en mujeres y se encuentra una historia familiar positiva en el 80% de los casos, sobre todo cuando estamos antes afectación bilateral.