Miracle-dz/UniFAR-FTUs huggingface dataset:
Management of antibacterial therapy of infectious and inflammatory diseases of the urinary tract in children and regional peculiarities during the COVID-19 pandemic

Urinary tract infections (UTIs) remain an urgent issue in clinical pediatrics. Empirical selection of antibacterial therapy becomes more complicated, and antibacterial drug indication is not always clinically substantiated. This study aimed to compare the antibacterial susceptibility pattern of the main group of urinary tract infectious agents from 2009–2016 with intermediate results from 2020–2021, during the COVID-19 pandemic, among children in the Chernivtsi region. Urine samples were collected from 3089 children (0–17 years old) treated at the health care institutions in the Chernivtsi region (2009–2016). The clinical-laboratory examination of 177 children (0–17 years old) was carried out from 2020 to 2021. The children received specialized medical care at the Department of Nephrology. Preliminary data of regional monitoring (2020–2021) are not considerably different from the previous regional susceptibility of antibiotics: to penicillin (p<0.01), ІІ-ІІІ generation cephalosporin (p<0.01); an increased resistance to levofloxacin (χ2=4,338; p<0.01), tetracycline – χ2=7,277; p<0.01; doxycycline – χ2=5,309; p<0.01) and imipenem – χ2=5,594; p<0.01). The data obtained did not explain an increased resistance to fluoroquinolones completely (ofloxacin, pefloxacin, ciprofloxacin), except for levofloxacin (χ2=4,338; p<0.01). A reliable difference of susceptibility of tetracycline group was registered (tetracycline – χ2=7,277; p<0.01; doxycycline – χ2=5,309; p<0.01). Furthermore, there was a regional increase in some UTI-pathogen strains resistant to carbapenems (imipenem – χ2=5,594; p<0.01). The use of antibiotics from the group of penicillins and II-III generation cephalosporins as the starting antibacterial therapy for STIs during the COVID-19 pandemic should be justified. A regional increase (2020–2021) of some uropathogenic strains resistant to carbapenems administered to treat severe bacterial infections requires their exclusively designated purpose in everyday pediatric practical work.
The Typology and Topography of Child Abuse and Neglect: The Experience of a Tertiary Children’s Centre

Effective child protection systems and processes require reliable and accurate data. The aim of this study was to determine what data could be extracted from hospital records in a single site that reflected a child’s journey from admission with suspected abuse to the decisions regarding substantiation made by the multidisciplinary child protection team. A retrospective study of the case records of 452 children referred to a major UK children’s tertiary centre for suspected child maltreatment was undertaken. Child maltreatment was substantiated in 65% of referred cases, with the majority of referrals coming from children living in the most deprived neighbourhoods in the country. Domestic violence and abuse and the child’s previous involvement with statutory bodies were associated with case substantiation. Physical abuse predominated, with soft tissue injuries, including dog bites and burns, most frequent. Burns were related almost exclusively to supervisory neglect. There were also cases of medical neglect. Emotional abuse was associated with exposure to domestic violence and abuse and to self-harm. The strengths and limitations for single-centre data systems were explored, concluding with a recommendation to establish an agreed national and international minimum data set to protect children from maltreatment.
SDG102, a H3K36-Methyltransferase-Encoding Gene, Plays Pleiotropic Roles in Growth and Development of Maize (Zea mays L.)

Although histone lysine methylation has been studied in thale cress (Arabidopsis thaliana (L.) Heynh. ) and rice (Oryza sativa L.) in recent years, its function in maize (Zea mays L.) remains poorly characterized. To better understand the function of histone lysine methylation in maize, SDG102, a H3 lysine 36 (H3K36) methylase, was chosen for functional characterization using overexpressed and knockout transgenic plants. SDG102-deficiency in maize caused multiple phenotypes including yellow leaves in seedlings, late-flowering, and increased adult plant height, while the overexpression of SDG102 led to reduced adult plant height. The key flowering genes, ZCN8/ZCN7 and MADS4/MADA67, were downregulated in SDG102-deficient plants. Chromatin immunoprecipitation (ChIP) experiments showed that H3 lysine 36 trimethylation (H3K36me3) levels were reduced at these loci. Perturbation of SDG102 expression caused the misexpression of multiple genes. Interestingly, the overexpression or knockout of SDG102 also led to genome-wide decreases and increases in the H3K36me3 levels, respectively. Together, our results suggest that SDG102 is a methyltransferase that catalyzes the trimethylation of H3K36 of many genes across the maize genome, which are involved in multiple biological processes including those controlling flowering time.
Evaluation of the spatial distribution of scenic resources based on 3S technology: A case study of the Yesanpo National Park

Evaluation of scenic resources is imperative in national park planning, and 3S technology has been applied for this purpose because it effectively leverages modern geo-informatics technology. We investigated the scenic resources in the Yesanpo National Park based on 3S technology. The Nearest-Neighbor Index, Kernel density estimation, imbalance index, and geographical concentration index in modern geography were introduced into the spatial distribution evaluation of scenic resources, and here, for the first time, the spatial combination index of scenic resources was proposed as one of the quantitative analysis indices of spatial distribution of scenic resources. Moreover, the spatial combination distribution characteristics of scenic resources were analyzed quantitatively and graphically. The characteristics of the spatial distribution of scenic resources in the Yesanpo National Park were as follows: The spatial distribution type of scenic spots in the Yesanpo National Park is a clustered type. The spatial distribution of the scenic resource groups in the Yesanpo National Park was extremely imbalanced and highly concentrated. Based on the identification of scenic resources, we evaluated the scenic resources of each area and propose sustainable development plans for each area. This evaluation method can be applied to similar national parks to promote the quantitative and graphical evaluation of the spatial distribution of scenic resources and provide support for the decision-making processes related to national park planning and management.
Static posturography as a novel measure of the effects of aging on postural control in dogs

Aging is associated with impairment in postural control in humans. While dogs are a powerful model for the study of aging, the associations between age and postural control in this species have not yet been elucidated. The aims of this work were to establish a reliable protocol to measure center of pressure excursions in standing dogs and to determine age-related changes in postural sway. Data were obtained from 40 healthy adult dogs (Group A) and 28 senior dogs (Group B) during seven trials (within one session of data collection) of quiet standing on a pressure sensitive walkway system. Velocity, acceleration, root mean square, 95% ellipse area, range and frequency revolve were recorded as measures of postural sway. In Group A, reliability was assessed with intraclass correlation, and the effect of morphometric variables was evaluated using linear regression. By means of stepwise linear regression we determined that root mean square overall and acceleration in the craniocaudal direction were the best variables able to discriminate between Group A and Group B. The relationship between these two center-of-pressure (COP) measures and the dogs’ fractional lifespan was examined in both groups and the role of pain and proprioceptive deficits was evaluated in Group B. All measures except for frequency revolve showed good to excellent reliability. Weight, height and length were correlated with most of the measures. Fractional lifespan impacted postural control in Group B but not Group A. Joint pain and its interaction with proprioceptive deficits influence postural sway especially in the acceleration in the craniocaudal direction, while fractional lifespan was most important in the overall COP displacement. In conclusion, our study found that pressure sensitive walkway systems are a reliable tool to evaluate postural sway in dogs; and that postural sway is affected by morphometric parameters and increases with age and joint pain.
Gewinnung von Stammzellen aus Nabelschnurblut: Relevanz peripartaler Faktoren für die Qualität von Transplantaten

Zusammenfassung Einleitung Nabelschnurblut (NSB) enthält hämatopoetische Stammzellen mit therapeutischem Potenzial und einzigartigen zellulären Eigenschaften. Aufgrund der begrenzten Anzahl an Stammzellen im NSB (Surrogatmarker total nucleated cells, TNC) eignet sich nur jede fünfte Spende für eine Transplantation. Ziel dieser Studie war es, zu untersuchen, ob prädiktive Faktoren für eine TNC-Zahl über der 99. Perzentile existieren. Material und Methodik Retrospektive Datenanalyse der 100 größten NSB-Spenden (Top100-Kohorte) aus 2299 registrierten Einheiten. Unterschiede zwischen maternalen, fetalen und geburtshilflichen Faktoren wurden analysiert und mit einer standardisierten Kohorte von 731 NSB-Spenden verglichen. Ergebnisse Das mütterliche Alter und der BMI in der Top100-Kohorte waren höher als in der Vergleichskohorte (32 vs. 31 Jahre, p=0,007; 30 kg/m2 vs. 29 kg/m2, p=0,024). Es gab mehr Erstgebärende (76,0 vs. 62,8%, p=0,013) und Gestationsdiabetikerinnen (5,00 vs. 1,65%, p=0,044). Die Schwangerschaftswoche, das Geburtsgewicht, der Anteil vaginal-operativer Geburten und sekundärer Sectiones war in der Top100-Kohorte höher (40+4 vs. 40+1 SSW, p=0,002), (3700 vs. 3450 g, p<0,001), (53,0 vs. 22,7%, p<0,001) (10 vs. 6,2%, p=0,014). Fazit Für eine erfolgreiche Transplantation ist die Höhe der TNC-Zahl entscheidend. Vaginal-operative Entbindungen, sekundäre Sectiones und ein Geburtsgewicht über 3700 g sind günstige Faktoren. Gerade bei Geburten mit einem pathologischen Verlauf sollte nach sicherer Versorgung von Mutter und Kind nicht auf eine Entnahme verzichtet werden.
Reconceptualizing inservice : a teacher designed staff development program.

Reconceptualizing Inservice: A Teacher Designed Staff Development Program June, 1978 Merrita Hruska, B.A., Michigan State University M.A., Michigan State University, Ed.D. , University of Massachusetts Directed by: Dr. R. Mason Bunker This study is concerned with the conception and implementation of comprehensive programs of staff development. A conceptual framework is offered to provide a scheme for changing inservice education as it exists traditionally. Elements essential in this reconceptualization include: (1) examination of concepts that have shaped inservice education as it is known today (2) presentation of a new set of concepts to guide future inservice education (3) presentation of a set of humanistically based beliefs about learning and learning environments to serve as a guide in the implementation of new designs. In examining concepts which have shaped inservice education and which continue to affect inservice education adversely and in examining those which could result in more effective designs, the following set of beliefs is purposed as a frame of reference. The focus is on the learning process and learning environments as described in theory and experience by humanistic psychologists and
Advanced Glycation End Products (AGEs) and Chronic Kidney Disease: Does the Modern Diet AGE the Kidney?

Since the 1980s, chronic kidney disease (CKD) affecting all ages has increased by almost 25%. This increase may be partially attributable to lifestyle changes and increased global consumption of a “western” diet, which is typically energy dense, low in fruits and vegetables, and high in animal protein and ultra-processed foods. These modern food trends have led to an increase in the consumption of advanced glycation end products (AGEs) in conjunction with increased metabolic dysfunction, obesity and diabetes, which facilitates production of endogenous AGEs within the body. When in excess, AGEs can be pathological via both receptor-mediated and non-receptor-mediated pathways. The kidney, as a major site for AGE clearance, is particularly vulnerable to AGE-mediated damage and increases in circulating AGEs align with risk of CKD and all-cause mortality. Furthermore, individuals with significant loss of renal function show increased AGE burden, particularly with uraemia, and there is some evidence that AGE lowering via diet or pharmacological inhibition may be beneficial for CKD. This review discusses the pathways that drive AGE formation and regulation within the body. This includes AGE receptor interactions and pathways of AGE-mediated pathology with a focus on the contribution of diet on endogenous AGE production and dietary AGE consumption to these processes. We then analyse the contribution of AGEs to kidney disease, the evidence for dietary AGEs and endogenously produced AGEs in driving pathogenesis in diabetic and non-diabetic kidney disease and the potential for AGE targeted therapies in kidney disease.
Morbidity and mortality patterns of preterm low birthweight neonates admitted to referral hospitals in the Amhara region of Ethiopia: retrospective follow-up study

Objective This study aimed to assess the morbidity and mortality patterns of preterm neonates with low birth weight admitted in the Amhara region referral hospitals in Ethiopia. Design Hospital-based retrospective follow-up study. Setting Amhara region referral hospitals, Ethiopia. Participants A total of 291 preterm neonates low birth weight that were admitted to referral hospitals in the Amhara region between 1 January 2017 and 30 December 2018 were reviewed. Data were entered into Epi-data V.4. 4.2. 1 and exported to STATA V.14 for analysis, and variables with a p value of <0.05 at 95% confidence level in multivariable logistic regression model analysis were declared as statistically significant associated factors of mortality. Primary outcome Morbidity and mortality patterns in preterm low birthweight neonates. Results This study revealed that 37.8% (95% CI 32.4% to 43.5%) of preterm low birthweight neonates died. The most common morbidities found were 219 (75.26%) hypothermia, followed by 201 (69.07%), 145 (49.83%), 39 (13.4%) and 24 (8.25%) with sepsis, respiratory distress, jaundice and congenital anomalies, respectively. Sepsis (AOR: 2.0; 95% CI 1.03 to 3.89), respiratory distress (AOR: 4.6; 95% CI 2.51 to 8.40), hypoglycaemia (AOR 3.91; 95% CI 1.09 to 10.52), APGAR score at fifth minute <7 (AOR 0.39; 95% CI (0.18 to 0.82) and duration of hospital stay below mean (<9.82 days) (AOR 0.17; 95% CI 0.09 to 0.33) were associated with mortality. Conclusion The mortality rate of preterm low birthweight neonates was high, indicating that this is a public health issue. Hypothermia, sepsis, respiratory distress, jaundice and congenital anomalies were the common morbidities. Sepsis, respiratory distress, hypoglycaemia, Apgar score at fifth minute <7 and duration of hospital stay below the mean were independent factors of mortality. However, these need to be further investigated in future research and appropriately addressed using prospective follow-up.
Temperature-Dependent Evolutionary Speed Shapes the Evolution of Biodiversity Patterns Across Tetrapod Radiations

Abstract Biodiversity varies predictably with environmental energy around the globe, but the underlaying mechanisms remain incompletely understood. The evolutionary speed hypothesis predicts that environmental kinetic energy shapes variation in speciation rates through temperature- or life history-dependent rates of evolution. To test whether variation in evolutionary speed can explain the relationship between energy and biodiversity in birds, mammals, amphibians, and reptiles, we simulated diversification over 65 myr of geological and climatic change with a spatially explicit eco-evolutionary simulation model. We modeled four distinct evolutionary scenarios in which speciation-completion rates were dependent on temperature (M1), life history (M2), temperature and life history (M3), or were independent of temperature and life-history (M0). To assess the agreement between simulated and empirical data, we performed model selection by fitting supervised machine learning models to multidimensional biodiversity patterns. We show that a model with temperature-dependent rates of speciation (M1) consistently had the strongest support. In contrast to statistical inferences, which showed no general relationships between temperature and speciation rates in tetrapods, we demonstrate how process-based modeling can disentangle the causes behind empirical biodiversity patterns. Our study highlights how environmental energy has played a fundamental role in the evolution of biodiversity over deep time. [Biogeography; diversification; machine learning; macroevolution; molecular evolution; simulation. ]
Treatment of cracked teeth: A comprehensive narrative review

The term “cracked tooth” is used to describe an incomplete fracture initiated from the crown and progressing towards a subgingival direction. Despite the high prevalence of cracked teeth and their frequent association with symptoms and pulpal or periapical pathoses, there is still no consensus in the literature with regard to their restorative and endodontic management. Therefore, the aim of this narrative review was to evaluate the most relevant research and provide an up‐to‐date comprehensive overview regarding the treatment of cracked teeth.
Pearls & Oy-sters: A Case Report of Holmes Tremor Due to Nigrostriatal Dopamine Disruption That Responded to Dopamine Replacement Therapy

Holmes tremor (HT), also known as midbrain, rubral, or cerebellar pathway outflow tremor, occurs because of disturbances of the cerebellothalamic pathway. This tremor is usually related to lesions in the midbrain peduncular region involving the superior cerebellar peduncle, the red nucleus, and possibly the nigrostriatal circuitry. Common etiologies resulting in HT include tumor, ischemia, and demyelination. We report a case of progressive left-sided HT in an otherwise healthy man with additional symptoms of parkinsonism, hypoesthesia, right oculomotor nerve palsy, cognitive dysfunction, and hypersomnolence. Imaging investigations revealed a right-sided thalamic and midbrain glioma. Dopamine transport imaging demonstrated significant dopaminergic denervation in the right caudate and putamen. The degree of striatal dopamine transporter deficiency was more severe than expected in a patient with Parkinson disease. A trial of dopaminergic agent resulted in significant improvement of the tremor and associated symptoms. Interruption of the nigrostriatal pathway can occur in cases of HT because of midbrain peduncular lesion. The striatal dopaminergic function imaging may have a role in assessing presynaptic dopamine dysfunction and guiding treatment.
Acute myocardial infarction with normal electrocardiogram and biomarkers of cardiac injury: A case report

Patients with AMI usually present with the specific changes for electrocardiogram (ECG) and biomarkers of cardiac injury. Here, we present a rare case with chest pain and normal ECG and biomarkers of cardiac injury. Emergent coronary angiography revealed an occlusion of proximal left anterior descending coronary artery . The patient was diagnosed with AMI, and his symptom relieved after implantation of drug‐eluting stents. Caution should be exercised for the exclusion of AMI in patients with chest pain and both normal ECG and biomarkers of cardiac injury.
Metodología para realizar mini-vídeos accesibles y multilingües para formación Universitaria - [A methodology to create accessible and multiligual mini-videos to learning higher education]

Lifelong learning is necessary at any institution or company. Self-training using mini-videos is an agile and effective option. However, the development of digital material needs resources: time, effort and money that could be unaffordable. In addition, these multimedia resources usually fail to comply the European Directive on Digital Accessibility. This paper presents a methodology for the development of low cost and accessible training mini-videos with multilingual support. It is understood that a minivideo is a video whose duration is approximately 5-10 minutes. Also, it presents the project in which this methodology and techniques are being applied for the training carried out by the Service of Library at the University of Jaén. This proposal will allow to refine and assess effectiveness and cost of current training. Finally, the proposal aims to define a systematic process of developing mini-videos that can be easily integrated into the Information Technology (IT) governance of any institution, organization or company.
New strategies on the application of artificial intelligence in the field of phytoremediation

Abstract Artificial Intelligence (AI) is expected to play a crucial role in the field of phytoremediation and its effective management in monitoring the growth of the plant in different contaminated soils and their phenotype characteristic such as the biomass of plants. This review focuses on recent applications of various AI techniques and remote sensing approaches in the field of phytoremediation to monitor plant growth with relevant morphological parameters using novel sensors, cameras, and associated modern technologies. Novel sensing and various measurement techniques are highlighted. Input parameters are used to develop futuristic models utilizing AI and statistical approaches. Additionally, a brief discussion has been presented on the use of AI techniques to detect metal hyperaccumulation in all parts of the plant, carbon capture, and sequestration along with its effect on food production to ensure food safety and security. This article highlights the application, limitation, and future perspectives of phytoremediation in monitoring the mobility, bioavailability, seasonal variation, effect of temperature on plant growth, and plant response to the heavy metals in soil by using the AI technique. Suggestions are made for future research in this area to analyze which would help to enhance plant growth and improve food security in long run. NOVELTY STATEMENT The review article focuses on recent applications of various artificial intelligence techniques and remote sensing approaches to monitoring plant growth as well as relevant morphological parameters using novel sensors, cameras, and associated modern technologies. Novel sensing techniques include multispectral sensors, hyperspectral sensors, infrared thermal imaging, RGB, LiDAR, fluorescence sensors, and UV sensors. Various measurement techniques are also discussed; these include near-infrared (NIR), NIR hyperspectral imaging, RGB, vis-NIR, Hyperspectral imaging, X-ray computed tomography (XRCT), MRI, and SAR. A brief study has also been done on the various application of phytoremediation potential in different contaminated soil. The opportunities, limitations, and future prospects of the AI technique in phytoremediation have been briefly discussed. However, an extensive study needs to be done on the application of AI on phytoremediation such as on heavy metal sequestration in plants, the effect of climate change on food security, carbon capture, etc. The efficiency and accuracy of data processing need to be more precise and improved from data acquisition. This article highlights the potential application of artificial intelligence in monitoring mobility, bioavailability, seasonal variation, the effect of temperature on plant growth, and plant response to the heavy metals in soil. The present review article can also help the readers/researchers to get a brief idea about the research gap and future perspective on the field of phytoremediation along with the application of various AI techniques. Graphical Abstract