Miracle-dz/UniFAR-FTUs huggingface dataset:
CblPhagocytosis by Transforming Mutants of Receptor-Mediated g Enhancement of Fc

2 Phagocytosis mediated by Fc g R plays an important role in host defense. The molecular events involved in this process have not been completely deﬁned. The adapter protein Cbl has been implicated in Fc g R signaling, but the function of Cbl in phagocytosis is unknown. Here we show that overexpression of the transforming mutants of Cbl, Cbl-70Z, and v-Cbl, but not wild-type (wt) Cbl, enhance phagocytosis mediated by Fc g R in COS cells. Cbl-70Z, but not Cbl-wt, also enhanced Fc g R-mediated phagocytosis in P388D1 murine macrophage cells. Cbl-70Z did not affect tyrosine phosphorylation or in vitro kinase activity of Syk, indicating that Syk may not be the direct target of Cbl-70Z in the enhancement of phagocytosis. A point mutation (G306E) in the phosphotyrosine domain of Cbl-70Z, as well as a C-terminal 67-aa deletion, partially abolished the enhancing effect on Fc g R-mediated phagocytosis. A double mutant of Cbl-70Z containing both the G306E mutation and the C-terminal deletion completely lacked the ability to enhance phagocytosis. Thus, both the phosphotyrosine binding domain and the carboxyl-terminal tail were required for optimal enhancement of phagocytosis by Cbl-70Z. Functional phosphatidylinositol 3-kinase was required for Cbl-70Z to enhance phagocytosis, since wortmannin, a phosphatidylinositol 3-kinase inhibitor, inhibited Fc g R-mediated phagocytosis in the presence of Cbl-70Z. These studies demonstrate that mutants of Cbl can modulate the phagocytic pathway mediated by Fc g R and imply a functional involvement of c-Cbl in Fc g receptor-mediated phagocytosis. The Journal of Immunology, 1999, 163:
Optimal Parameter Selection Using Three-term Back Propagation Algorithm for Data Classification

The back propagation (BP) algorithm is the most popular supervised learning method for multi-layered feed forward Neural Network. It has been successfully deployed in numerous practical problems and disciplines. Regardless of its popularity, BP is still known for some major drawbacks such as easily getting stuck in local minima and slow convergence; since, it uses Gradient Descent (GD) method to learn the network. Over the years, many improved modifications of the BP learning algorithm have been made by researchers but the local minima problem remains unresolved. Therefore, to resolve the inherent problems of BP algorithm, this paper proposed BPGD-A3T algorithm where the approach introduces three adaptive parameters which are gain, momentum and learning rate in BP. The performance of the proposed BPGD-A3T algorithm is then compared with BPGD two term parameters (BPGD-2T), BP with adaptive gain (BPGD-AG) and conventional BP algorithm (BPGD) by means of simulations on classification datasets. The simulation results show that the proposed BPGD-A3T shows better performance and performed highest accuracy for all dataset as compared to other.
Merced Electronic and Pathways Between Maternal Relationship Quality, Perceived Patient-Centered Communication, Self-Efficacy, and Type 1 Diabetes Management Among Early Emerging Adults

This study examined whether maternal relationship quality provides a context for patient-centered communication with providers leading to better type 1 diabetes management through self-efficacy among early emerging adults, and whether associations were stronger among those who transferred to adult care. Early emerging adults with type 1 diabetes one year post high school participated when 51% had transferred to adult care (N=203; 60% female; M age=18.81). On-line surveys measured perceived relationship quality with mothers, patient-centered communication with providers, self-efficacy for diabetes management, and adherence. Glycemic control was measured via HbA1c mail-in assay kits. Structural equation modeling indicated that higher maternal relationship quality was associated with higher patient-centered communication, which was indirectly associated with better adherence and glycemic control through self-efficacy; no moderation occurred by transfer to adult care status. Perceptions of patient- centered communication with providers occur in families with high mother relationship quality. These results suggest that the social context may be beneficial for early emerging adults’ diabetes management in part, because it contributes to higher self-efficacy among early emerging adults.
The influence of body posture parameters on selected parameters of the dynamic foot analysis

Introduction and purpose of work. The correct body posture and its evaluation in children of all ages is of great importance. Special attention should be paid to two critical periods, when the posture may deteriorate significantly. Monitoring the body posture makes it possible to detect any abnormalities at an early stage that may subsequently lead to other health problems. The aim of the paper was to analize the connections between the body posture parameters and the selected parameters of the dynamic foot examination. Material and methods. 106 children at the age of 10-15 years old from schools located in the Świętokrzyskie Voivodeship took part in the study. The posture of children assessed with the use of the Diers system is analyzed using a three-dimensional light-optical system. The next stage of the research was to conduct the dynamic foot analysis on the FreeMed platform.Results. No dependence between the majority of the studied body posture parameters and the parameters of the dynamic analysis was found. A statistically significant dependence was observed between: the right foot surface and the pelvic tilt, the right foot surface and the rotation surface, the number of steps per minute and the pelvic tilt, the contact time of the right foot surface and the pelvic tilt. When the pelvic tilt was standard, the authors observed a smaller surface while loading the right foot, a greater number of steps, and a shorter right foot contact time. The standard surface rotation affected the larger foot surface in the dynamic analysis.Conclusion. The study needs to be continued and extended in order to verify if there are any dependencies between the body posture parameters and the selected parameters of the dynamic analysis of the foot and gait pressure in children.
The use of various proportions of rough fish and pellets on the growth of giant trevally fish ( Caranx hippos ) in the east coast floating net cages (KJA Pantai timur), pangandaran

The aim of this research is to obtain the proportion of rough fish and pellets in fish feed that gives survival rate, daily growth rate and the best feeding efficiency to giant trevally fish ( Caranx hippos ). of 25 fish per net with a net size of 1.5 m x 1.5 m x 1.5 m in the East Coast floating net cages, Pangandaran and were treated with a combination of rough fish and pellets as their feed. The research method used was Completely Randomized Design (CRD) and consisted of 4 treatments and 3 replications: A (100% rough fish), B (75% rough fish: 25% pellet), C (50% rough fish: 50% pellet), and D (25% rough fish: 75% pellets). Data analysis with the F test continued with Duncan's Multiple Range Test. The results of the research showed that the provision of proportion of rough fish and pellet feed could have an effect on increasing growth rate (LPH) and feeding efficiency (EPP). Treatment A (100% trash) gave the best LPH value of 2.57%, and treatment C (50% trash: 50% pellet) gave the best value for EPP of 19.01%. For the survival of the giant trevally fish for each treatment gives a value of 100%, namely the absence of death.
EFFECTIVENESS OF AMULYA AMRITATULSI RASAYAN AND AMULYA ENERGY Z CAPSULES IN TREATING TYPHOID: A CASE STUDY

Amulya Amritatulsi Rasayan- containing extracts of just two plants - Tulsi ( Ocimum sanctum ) and Geloye ( Tinospora cordifolia ) is a proprietary anti-infective herbal (Ayurvedic) formulation being manufactured by Amulya Herbs Pvt. Limited, Panchkula (India). In combination with Amulya Energy Z capsules, the formulation is found to be highly effective in the treatment of typhoid. Amulya Energy Z capsules are a dietary supplement containing Ashwagandha ( Withania somnifera ), Safed Musli ( Chlorophytum borivilianum ), vitamins and minerals. Tulsi is considered as one of the holiest and most healthiness giving herbs in India. Geloy, Ashwagandha and Safed Musli the other three herbs used in formulation are available in India and known for medicinal use since ancient times. These plants are used in Ayurvedic system of medicine for total rejuvenation, immunomodulation, antibacterial activity and as antioxidants. Since ages the therapeutic uses of these plants are considered as safe, inexpensive and efficient. They heal many diseases due to chemical constituents present in different parts of plants. Antibacterial activity of chemical constituents of Geloy, Tulsi, Ashwagandha and Safed Musli against Salmonellosis is well documented. Thirty „Widal test positive‟ Typhoid Patients, who were given 400mg Cefixime 1BD and paracetamol 500mg SOS by allopathic doctor for 15 days with no sign of recovery were successfully treated in Ayusham Health Care, Plot No 293, Industrial area, Phase-1, Panchkula, Haryana, India, using Amulya Amritatulsi Rasayan capsule 500mg, containing 50:50 combination of Ocimum sanctum and Tinospora cordifolia, twice a day for thirty days, along with Amulya Energy Z capsules 500mg, containing herbal extracts of Ashwagandha ( Withania somnifera ) 300mg , Safed Musli ( Chlorophytum borivilianum )100mg, vitamins and minerals once a day for 30 days. The present case study suggests that the biologically active components of Tulsi and Geloy in combination with Ashwagandha and Safed Musli had synergistic activity against Salmonella typhi and show promise as an alternative cheap non-antibiotic combination for the effective treatment of for S. typhi infection.
Capital Structure, Liquidity and Investment Growth of Listed Conglomerate Firms in Nigeria: Moderating Effect of Firm Size

This study examines the moderating effects of short term, long term and liquidity and on investment growth, using listed conglomerate firms in Nigeria. The main objective of the study is to ascertain the level to which short term, long term and liquidity influences the investment growth of listed conglomerate firms in Nigeria from 2011-2020 and how the effect is moderated by firm size. The methodology employed is the use of secondary data and the ex-post facto research design. The population of the study consists of all six conglomerate firms listed on the Nigerian Stock Exchange as at December, 2020. The study used multiple regression as a tool of analysis. Findings show that Short Term Debt does not have significant effect, while Long Term Debt has a significant positive effect on investment growth of listed conglomerate firms in Nigeria. Also, the study found that firm size has a significant moderating effect on the relationship between short term debts as well as on liquidity on investment growth. The study recommends that conglomerate firms should maintain a minimal level of short-term debt and liquidity because tying down too much of its current assets will reduce investment opportunities. Similarly, the management of listed conglomerate firms should increase the level at which the organizations use Long Term Debt to finance their business activities, as this may go a long way in increasing the investment opportunity potentials of the organizations.
N-Terminal Pro-B-Type Natriuretic Peptide Predicts Total and Cardiovascular Mortality in Individuals with or without Stable Coronary Artery Disease: The Ludwigshafen Risk and Cardiovascular Health Study Proteomics and Protein Markers

Background: Measurement of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) can be used to predict mortality in patients with acute coronary syndromes. Information on the value of NT-pro-BNP in clinically stable persons scheduled for angiography is limited. Methods: We used Cox proportional hazards regression to examine the effect of NT-pro-BNP on total and cardiovascular mortality in 1135 with and 506 individuals without stable coronary artery disease (CAD). Results: NT-pro-BNP was associated with New York Heart Association functional class, left ventricular (LV) systolic function, and LV end-diastolic pressure. NT-pro-BNP was positively related to age, female sex, hypertension, and former and current smoking and negatively related to body mass index and glomerular filtration rate. During a median follow-up of 5.45 years, NT-pro-BNP concentrations of 100–399, 400-1999, or > 2000 ng/L resulted in unadjusted hazard ratios (95% CI) for all-cause death of 3.2 (1.8–5.6), 6.63 (3.8–11.6), and 16.5 (9.2–29.8), respectively, compared with concentrations < 100 ng/L. Hazard ratios (CI) for death from cardiovascular causes were 3.8 (1.8–8.2), 9. 3 (4.4–19.5), 22.2 (10.2–48.4). NT-pro-BNP remained predictive of total and cardiovascular mortality after accounting for age, sex, diabetes mellitus, body mass index, smoking, hypertension, dyslipidemia,
Sensor fusion for vehicle tracking based on the estimated probability

The track-to-track fusion (T2TF) algorithm is currently an attractive fusion methodology in the industry because the algorithm can reflect the reliability of sensor tracks. However, the T2TF algorithm cannot be applied when the probability information of the sensor is unknown. The aim of this study is to exploit the T2TF algorithm even in the absence of the probability information of the sensor. The covariance is estimated using the recursive equations of the Kalman filter. In addition, a novel track-association approach using the total similarity is developed to improve association performance. The total similarity complements the defects of the track disposition and the estimated track history. Finally, by fusing the associated tracks using the estimated covariance, the T2TF algorithm is successfully applied to sensors with an unknown covariance. The fusion results are then evaluated using the correct association rate and the optimal subpattern assignment metric. The simulation results obtained show the superiority of the proposed algorithm under three scenarios.
Mechanics of pressurized planar hyperelastic membranes

The paper examines the mechanics of inflation of incompressible planar hyperelastic membranes that are rigidly fixed at their boundary and subjected to a uniform pressure. Strain energy functions characterized by the neo-Hookean, Mooney–Rivlin and the Ogden forms are used. Fixity is provided along either circular or elliptical boundaries. The computational results indicate that the strain energy function has a significant influence on the pressure versus inflated volume response of the deformed membrane. When the strain energy function corresponds to a Mooney–Rivlin form, the circular membrane displays no tendency to develop any instability. The equivalent circular membranes composed of both the neo-Hookean and Ogden-type strain energy functions developed an initial ‘Wrinkling Instability’. For planar membranes with an elliptical planform, the wrinkling instability is more pronounced; membranes composed of hyperelastic materials with a Mooney–Rivlin form of the strain energy function continue to deform without the development of an initial instability point, whereas membranes composed of both the neo-Hookean and Ogden materials exhibit wrinkling behaviour at critical locations at the interior of the fixed boundary region. The dependency of the strain energy function on the second invariant of the Cauchy–Green strain tensor has an influence in the suppression of hyperelastic effects. This article is part of the theme issue 'The Ogden model of rubber mechanics: Fifty years of impact on nonlinear elasticity'.
Identification of Building Wall Orientation Angle with Multilook Synthetic Aperture Radars Processing

A new technique of identifying orientation angles of walls of buildings has been proposed in this paper. The present method is based on multilook processing. The aim of this work is to find the relationships between the received signals reflected from uniform targets (e.g. walls, parts of buildings, etc.) positioned at dierent orientation angles towards the radar platform. The technique is dedicated for synthetic aperture radars systems. It can be used to extend target identification in synthetic aperture radars images obtained by a single-channel antenna. In this paper, theoretical analysis is presented and verified with simulated radar data. PACS: 84.40. Xb
Strichartz estimates for gravity water waves

We prove Strichartz estimates for gravity water waves, in arbitrary dimension and in fluid domains with general bottoms. We consider rough solutions such that, initially, the first order derivatives of the velocity field are not controlled in $L^\infty$-norm, or the initial free surface has a curvature not controlled in $L^2$-norm.
Autophagy Restricts HIV-1 Infection by Selectively Degrading Tat in CD4 (cid:2) T Lymphocytes

Autophagy is a ubiquitous mechanism involved in the lysosomal-mediated degradation of cellular components when they are engulfed in vacuoles called autophagosomes. Autophagy is also recognized as an important regulator of the innate and adaptive immune responses against numerous pathogens, which have, therefore, developed strategies to block or use the autophagy machinery to their own beneﬁt. Upon human immunodeﬁciency virus type 1 (HIV-1) infection, viral envelope (Env) glycoproteins induce autophagy-dependent apoptosis of uninfected bystander CD4 (cid:2) T lymphocytes, a mechanism likely contributing to the loss of CD4 (cid:2) T cells. In contrast, in productively infected CD4 (cid:2) T cells, HIV-1 is able to block Env-induced autophagy in order to avoid its antiviral effect. To date, nothing is known about how autophagy restricts HIV-1 infection in CD4 (cid:2) T lymphocytes. Here, we report that autophagy selectively degrades the HIV-1 transactivator Tat, a protein essential for viral transcription and virion production. We demonstrated that this selective autophagy-mediated degradation of Tat relies on its ubiquitin-indepen-dent Flow cytometry. The percentage of HIV-1-infected cells was deter-mined by quantifying the cellular levels of p24 Gag by ﬂow cytometry using anHIVKC57ﬂuoresceinisothiocyanate(FITC)kitaccordingtotheman-ufacturer’sinstructions(BeckmanCoulter). Brieﬂy,cellswereﬁxedandpermeabilized,andtheanti-p24antibodywasaddedtothecells.Afterstainingfor30min,cellswerewashedwithphosphate-bufferedsaline(PBS),andﬂuorescenceintensitywasmeasuredonaCoulterEpicsXL Flow Cytometer (Beckman Coulter). (cid:3) -Galactosidase assay. A chemiluminescent reporter assay system, Galacto-Star (cid:4) -Galactosidase Reporter Gene Assay System for Mammalian Cells, from Life Technologies, was used to quantitate ß-galactosidase activity according to the manufacturer’s instructions. Brieﬂy, 0.5 (cid:6) 10 6 MAGIC5B cells were lysed in 200 (cid:5) l of lysis buffer provided by the man-ufacturer. Fifty microliters of cell lysate was used in each assay, in dupli-cates. The results were normalized by quantifying the total protein con-centrations using a Bradford assay from Sigma-Aldrich.
Institutional Knowledge at Singapore Management University Institutional Knowledge at Singapore Management University Mining Business Competitiveness from User Visitation Data Mining Business Competitiveness from User Visitation Data

Ranking businesses by competitiveness is useful in many applications including business (e.g., restaurant) recommendation, and estimation of intrinsic value of businesses for mergers and acquisitions. Our literature reveals that previous methods of business ranking have ignored the competing relationship among businesses within their geographical areas. To account for competition, we propose the use of PageRank model and its variant to derive the Competitive Rank of businesses. We use the check-ins of users from Foursquare, a location-based social network, to model the winners of competitions among stores. The results of our experiments show that Competitive Rank works well when evaluated against ground truth business ranking.
Failing To Induce Dendritic Cell Maturation Cells, but Evades Adaptive Immunity by Is Killed by Dendritic Cryptococcus gattii

During adaptive immunity to pathogens, dendritic cells (DCs) capture, kill, process, and present microbial Ags to T cells. Ag presentation is accompanied by DC maturation driven by appropriate costimulatory signals. However, current understanding of the intricate regulation of these processes remains limited. Cryptococcus gattii , an emerging fungal pathogen in the Paciﬁc Northwest of Canada and the United States, fails to stimulate an effective immune response in otherwise healthy hosts leading to morbidity or death. Because immunity to fungal pathogens requires intact cell-mediated immunity initiated by DCs, we asked whether C. gattii causes dysregulation of DC functions. C. gattii was efﬁciently bound and internalized by human monocyte-derived DCs, trafﬁcked to late phagolysosomes, and killed. Yet, even with this degree of DC activation, the organism evaded pathways leading to DC maturation. Despite the ability to recognize and kill C. gattii , immature DCs failed to mature; there was no increased expression of MHC class II, CD86, CD83, CD80, and CCR7, or decrease of CD11c and CD32, which resulted in suboptimal T cell responses. Remarkably, no increase in TNF- a was observed in the presence of C. gattii. However, addition of recombinant TNF- a or stimulation that led to TNF- a production restored DC maturation and restored T cell responses. Thus, despite early killing, C. gattii evades DC maturation, providing a potential explanation for its ability to infect immunocompetent individuals. We have also established that DCs retain the ability to recognize and kill C. gattii without triggering TNF- a , suggesting independent or SEM. Statistical analysis tests two- tailed paired Student t test, one-way and two-way ANOVAwith Bonferroni multiple comparison test, one-way ANOVA with Tukey multiple comparison test when appropriate. For all experiments, 0.05, 0.001, statistically signiﬁcant
Journal for Learning through the Arts My Have a Pulse and a Downbeat” The Role of Folk and Traditional Arts Instruction in Supporting Student Learning

The authors investigated the association between participation in Nations in Neighborhoods (NiN), a program of folk and traditional arts instruction and achievement in English language arts in a sample of low-income elementary school students, many of whom were recent immigrants and English language learners. The program drew on the core practices of traditional and folk arts – sociocritical literacies that bridge home and school, multi-modal instruction, apprenticeship learning, and communal effort – to provide students with the confidence and strategies of accomplished learners. English language arts achievement was assessed using a standardized state proficiency exam. Students who participated in the program received significantly-higher overall scores on the exam after controlling for gender, ethnicity, English language learner and special education classifications. These findings suggest that an arts education program featuring folk and traditional arts engages students in practices that have measurable effects on their literacy development.