Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Photoperiod Alterations on Stress Response in Daphnia magna

In the modern world people are often impacted by factors that control when they can sleep and for how long, which results in an altered photoperiod. Alterations in photoperiod can occur from a variety of factors, ranging from working night shifts to travelling and changing time zones, and therefore influence the daily lives of many people. The purpose of these experiments was to determine if alterations in photoperiod affect the stress response in Daphnia magna. We hypothesized that if Daphnia magna are exposed to alterations in photoperiod, then there will be an increased stress response. We kept two distinct Daphnia populations and exposed the experimental group to a shorter photoperiod of 12 hours instead of the traditional 24-hour photoperiod. During the testing period, we tracked possible stress responses, including mean heart rate, brood size and male-to-female ratio. There were statistically significant differences between the control and experimental groups for both heart rate and brood size. Specifically, the experimental group exhibited an increased heart rate and brood size relative to the control group. Within the experimental group, there was statistically significant variation in the brood size over time, with the peak brood size occurring on day three or four in the seven-day trial. Male-to-female ratio did not have a statistically significant response to the altered photoperiod. The results found support the hypothesis of increased stress when photoperiod is altered, which could also indicate that altered photoperiod may have an impact on people that constantly experience changes in their photoperiod.
Response of the magnetosheath‐cusp region to a coronal mass ejection

and Bz changed from highly negative to positive up to 25 nT. The responses of the magnetosheath-cusp region during the unusual event are presented using Cluster and ground-based (EISCAT VHF radar; 69.6N, 19.2E) observations. The unusual Cluster crossing (compared to the usual midaltitude cusp crossing at this time of the year) occurred owing to a large compression of the magnetosphere. Cluster, which was in the southern magnetospheric lobe, suddenly found itself in the magnetosheath at the arrival of the CME at 1524:45 UT. Cluster then crossed through the compressed magnetosheath (highly compressed after the discontinuity in the CME) for about 1.5 hours (1525– 1655 UT), magnetopause with strong signatures of lobe reconnection (1655 UT), stagnant but compressed exterior cusp for about an hour (1700–1802 UT), and then entered the dayside magnetosphere. The observations also show strong signatures of magnetosphere-ionosphere coupling through a late afternoon (17 MLT) cusp during the first 40 min (1525–1605 UT) of the event when IMF Bz remained negative. Strong magnetic waves are also generated in the magnetosheath-cusp region.
Research Africa Network (RAN) RAN Working Paper

This paper seeks to gain insights into whether developing countries benefit more from the backwardness advantage for economic growth in the Information Age. The paper examines this concern through three complementary approaches. First, it derives theoretical grounds from the existing economic models to support the hypothesis that the internet, inter alia, enables developing countries to reap greater growth gains from technology acquisition and catch-up. Second, the paper uses descriptive evidence to show that the growth landscape has indeed shifted decisively in favor of developing countries in the Internet Age in comparison to the pre-internet period. Third, using rigorous econometric techniques with data of 163 countries over a 20-year period, 1996-2016, the paper evidences that developing countries on average reap significantly greater growth gains from internet adoption in comparison to the average advanced country. The paper discusses policy implications from the paper’s findings.
Simulation of intense monsoons under glacial conditions

Paleoenvironmental and paleoclimatological proxy data indicate that strong continental monsoons took place under glacial conditions during marine isotopic stage 6.5 (175 ka BP). So far, no climate model has explored the possible coexistence of glacial conditions at mid and high latitudes and of interglacial monsoons in the tropics. Here we use an atmospheric general circulation model and clearly demonstrate that high insolation can generate increased monsoon activity even with surface glacial conditions. Our experiments show that Indian and African monsoons at 175 ka were stronger than nowadays and induced an increase in outflow of the Nile river to the Mediterranean sea. This freshwater supply combined with the local low glacial evaporation may explain the stagnation of the Eastern Mediterranean sea leading to the deposit of sapropel S6. Our simulations show also increased surface winds in the northern Atlantic and Pacific oceans which may have affected the bioproductivity in these areas.
Contents of Cu, Ni and Zn in smelter-polluted soil–plant systems

Intact soil profiles including litter layer and ground vegetation were taken at five distances (0.5, 2, 4, 8 and 60 km) from a Cu–Ni smelter in Harjavalta, SW Finland. The soil cores were placed in 10 l pots and a 4 year-old, bare-rooted pine seedling (Pinus sylvestris L.) was planted in each. The containers were incubated for17 months in controlled greenhouse conditions. At the end of the experiment the seedlings were harvested and soil samples were taken from each pot and analysed for Cu, Ni and Zn. The absence of atmospheric metal deposition had no reducing effect on the exchangeable heavy-metal contents of the soil pots. Metal uptake by the plant seedlings during the experiment had a negligible effect on the exchangeable heavy-metal content of the soil cores from the most polluted sites. The increase in both the exchangeable and the total humus Cu, Ni and Zn concentrations in the 0.5 km soil cores during the experiment suggested that there were pools of accumulated metals in the thick litter layer on top of the humus.
TaskVine: Managing In-Cluster Storage for High-Throughput Data Intensive Workflows

Many scientific applications are expressed as high-throughput workflows that consist of large graphs of data assets and tasks to be executed on large parallel and distributed systems. A challenge in executing these workflows is managing data: both datasets and software must be efficiently distributed to cluster nodes; intermediate data must be conveyed between tasks; output data must be delivered to its destination. Scaling problems result when these actions are performed in an uncoordinated manner on a shared filesystem. To address this problem, we introduce TaskVine: a system for exploiting the aggregate local storage and network capacity of a large cluster. TaskVine tracks the lifetime of data in a workflow –from archival sources to final outputs– making use of local storage to distribute, and re-use data wherever possible. We describe the architecture and novel capabilities of TaskVine, and demonstrate its use with applications in genomics, high energy physics, molecular dynamics, and machine learning.
Sensory Ecology: Noise Annoys Foraging Bats

References 1. Arendt, D. (2008). The evolution of cell types in animals: emerging principles from molecular studies. Nat. Rev. Genet. 9, 868–882. 2. Arendt, D. , Tessmar, K. , de CamposBaptista, M.I. , Dorresteijn, A. , and Wittbrodt, J. (2002). Development of pigment-cup eyes in the polychaete Platynereis dumerilii and evolutionary conservation of larval eyes in Bilateria. Development 129, 1143–1154. 3. Serb, J.M. , and Oakley, T.H. (2005). Hierarchical phylogenetics as a quantitative analytical framework for evolutionary developmental biology. BioEssays 27, 1158–1166. 4. Lucas, R.J., Hattar, S. , Takao, M. , Berson, D.M. , Foster, R.G. , and Yau, K. -W. (2003). Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice. Science 299, 245–247. 5. Arendt, D. , Tessmar-Raible, K. , Snyman, H. , Dorresteijn, A.W. , and Wittbrodt, J. (2004). Ciliary photoreceptors with a vertebrate-type opsin in an invertebrate brain. Science 306, 869–871. 6. Kozmik, Z. , Ruzickova, J., Jonasova, K. , Matsumoto, Y. , Vopalensky, P., Kozmikova, I. , Strnad, H. , Kawamura, S. , Piatigorsky, J., Paces, V. , et al. (2008). Assembly of the cnidarian camera-type eye from vertebrate-like components. Proc. Natl. Acad. Sci. USA 105, 8989–8993. 7. Suga, H. , Schmid, V. , and Gehring, W.J. (2008). Evolution and functional diversity of jellyfish opsins. Curr. Biol. 18, 51–55. 8. Erclik, T. , Hartenstein, V. , Howard, D. , Lipshitz, H.D. , and McInnes, R.R. (2008). Conserved role of the Vsx genes supports a monophyletic origin for bilaterian visual systems. Curr. Biol. 18, 1278–1287. 9. Eakin, R.M. , and Brandenburger, J.L. (1980). Unique eye of probable evolutionary significance. Science 211, 1189–1190. 10. Arendt, D. , and Wittbrodt, J. (2001). Reconstructing the eyes of Urbilateria. Phil. Trans. R. Soc. Lond. B 356, 1545–1563. 11. Nilsson, D. -E. (1994). Eyes as optical alarm systems in fan worms and ark clams. Phil. Trans. R Soc. Lond. B 346, 195–212. 12. Jarman, A.P., Grell, E.H. , Ackerman, L. , Jan, L.Y. , and Jan, Y.N. (1994). atonal is the proneural gene for Drosophila photoreceptors. Nature 369, 398–400. 13. Holmberg, K. (1977). The cyclostome retina. In Handbook of Sensory Physiology, Vol. VII/5, F. Crescitelli, ed. (Berlin: Springer), pp. 47–66. 14. Lamb, T.D. , Collin, S.P., and Pugh, E.N. , Jr. (2007). Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nat. Rev. Neurosci. 8, 960–975. 15. Lacalli, T.C. (2004). Sensory systems in amphioxus: A window on the ancestral chordate condition. Brain Behav. Evol. 64, 148–162.
Principle and experiment study of non-modulated 1064nm CW Doppler fiber LADAR system

Nowadays LADAR system set on practical moving platform is purposed to detect real-time velocity as well as precise distance and direction evaluation for safe landing or obstacles avoiding. On account of narrow band, brief algorithm, non-modulated CW Doppler LADAR based on optical heterodyne principle could acquire the velocity of multiple targets with high frame frequency, high SNR ratio while no velocity ambiguity. In this paper, a non-modulated 1064nm CW Doppler fiber LADAR system with high frame frequency as well as high velocity precision is proposed. The experimental result of the system shows a velocity precision of 6.65mm/s, and a velocity detection frame frequency of 20FPS, which essentially meet the practical demands.
Shape-induced pseudo-single-domain remanence

Summary Models of uniaxial hard magnetic particles show that irregularly shaped grains possess a considerable equilibrium remanence due to domain imbalance. This remanence decreases approximately as L− 1 with grain size L and is very stable with respect to alternating field and thermal demagnetization. It is therefore likely to be a major source of pseudo-single-domain remanence in rocks. Using the methods of domain theory, the range of possible remanences in irregularly shaped uniaxial particles with less than five domains is investigated. Even for slightly asymmetric particle geometries the remanence decreases monotonically with grain size. Most two-domain remanences lie above 0.3 Ms. The behaviour of the domain imbalance moments seems to be largely independent of details of the shape asymmetry. Since domain imbalance is a global equilibrium remanence, local remanences due to wall pinning effects can be superimposed with-out destroying it. This can explain the fact that the remanence of pseudo-single-domain particles appears to be a mixture of independent single- and multidomain-like components.
Uterine Neoplasms, Version 1.2023

Adenocarcinoma of the endometrium (also known as endometrial cancer, or more broadly as uterine cancer or carcinoma of the uterine corpus) is the most common malignancy of the female genital tract in the United States. It is estimated that 65,950 new uterine cancer cases will have occurred in 2022, with 12,550 deaths resulting from the disease. Endometrial carcinoma includes pure endometrioid cancer and carcinomas with high-risk endometrial histology (including uterine serous carcinoma, clear cell carcinoma, carcinosarcoma [also known as malignant mixed M € ullerian tumor
An Unbiased Look at Datasets for Visuo-Motor Pre-Training

Visual representation learning hold great promise for robotics, but is severely hampered by the scarcity and homogeneity of robotics datasets. Recent works address this problem by pre-training visual representations on large-scale but out-of-domain data (e.g., videos of egocentric interactions) and then transferring them to target robotics tasks. While the field is heavily focused on developing better pre-training algorithms, we find that dataset choice is just as important to this paradigm's success. After all, the representation can only learn the structures or priors present in the pre-training dataset. To this end, we flip the focus on algorithms, and instead conduct a dataset centric analysis of robotic pre-training. Our findings call into question some common wisdom in the field. We observe that traditional vision datasets (like ImageNet, Kinetics and 100 Days of Hands) are surprisingly competitive options for visuo-motor representation learning, and that the pre-training dataset's image distribution matters more than its size. Finally, we show that common simulation benchmarks are not a reliable proxy for real world performance and that simple regularization strategies can dramatically improve real world policy learning. https://data4robotics.github. io
An explainable model for content moderation

12). Through a technique known as backpropagation, the network can adjust the weights of its nodes to improve its performance, learning patterns in data. The output of a large network is the result of many connections across millions or billions of nodes. Neural networks can achieve state-of-the-art performance on language tasks, but it is far more challenging to identify how a single feature influences the network’s output (13). In this study, we hypothesized that by identifying keywords and quantifying their contribution to a news article’s credibility, we could predict credibility by summing the contributions of all
Expressed by Bone Marrow Mesenchymal Stromal Cells Regulates Early B-Cell Lymphopoiesis( Dissertation

The transcription factor CCAAT/enhancer-binding protein β (C/EBPβ) regulates the differentiation of a variety of cell types. Here, the role of C/EBPβ expressed by bone marrow mesenchymal stromal cells (BMMSCs) in B-cell lymphopoiesis was examined. The size of the precursor B-cell population in bone marrow was reduced in C/EBPβ-knockout (KO) mice. When bone marrow cells from C/EBPβ-KO mice were transplanted into lethally irradiated wild-type (WT) mice, which provide a normal bone marrow microenvironment, the size of the precursor B-cell population was restored to a level equivalent to that generated by WT bone marrow cells. In co-culture experiments, BMMSCs from C/EBPβ-KO mice did not support the differentiation of WT c-Kit + Sca-1 + Lineage - hematopoietic stem cells (KSL cells) into precursor B-cells, whereas BMMSCs from WT mice did. The impaired differentiation of KSL cells correlated with the reduced production of CXCL12/stromal cell-derived factor-1 by the co-cultured C/EBPβ-deficient BMMSCs. The ability of C/EBPβ-deficient BMMSCs to undergo osteogenic and adipogenic differentiation was also defective. The survival of leukemic precursor B-cells was poorer when they were co-cultured with C/EBPβ-deficient BMMSCs than when they were co-cultured with WT BMMSCs. These results indicate that C/EBPβ expressed by BMMSCs plays a crucial role in early B-cell lymphopoiesis.
Juglon-selenyum Uygulamalarının BxPC-3 ve PANC-1 İnsan Pankreatik Kanser Hücrelerinde Epitelyal-mezenkimal Geçiş ve Migrasyon Üzerindeki Etkilerinin Araştırılması

Objective: Chemotherapy is still the most common and primary treatment option for treating pancreatic cancers because metastasis has already occurred at the time of diagnosis, difficulties of the operation due to its location, and lack of targeted treatment approaches. Moreover, the high chemoteuropatic resistance seen in pancreatic cancer makes research on alternative drug treatments mandatory. Juglone, a natural naphthaquinone found in members of the Juglandaceae family, has various pharmacological effects such as antiviral and antibacterial. It has also been shown to be an effective cytotoxic agent through the production of reactive oxygen species in studies conducted with cancer cell lines. Remarkably, selenium, an important trace element of the cell, was shown to inhibit metastasis, strengthen cell-cell attachments, and reduce angiogenesis. Based on these data, we investigated the effects of juglone-selenium (J/S) combination on epithelial-mesenchymal transition (EMT) and migration in PANC-1 and BxPC-3 cells. Methods: The effects of juglone application in the presence of 2,5 µM NaSe at 5, 10, 15 and 20 µM concentrations on the expression of FOXL1 , VIM , and MMP-7 genes were determined by qPCR. In addition, the effects of J/S on the migration features of cancer cells were monitored by wound healing tests. Results: According to qPCR results, J/S application showed different effects on FOXL1, VIM , and MMP-7 gene expressions, which are critical for EMT, in both cell lines. According to the wound healing assay results, the migration of cancer cells was suppressed in both cell lines compared with the control group. Conclusion: Consequently, our studies have supported that juglone can be an effective therapeutic agent on pancreatic cancer, and our findings also suggest that selenium can strengthen these anticancer effects of juglone.
HRMobile: A lightweight, local architecture for heart rate measurement

Heart rate and heart rate variability (HRV) are important metrics in the study of numerous physical and psychiatric conditions. Previously, measurement of heart rate was relegated to clinical settings, and was neither convenient nor captured a patient’s typical resting state. In effect, this made gathering heart rate data costly and introduced noise. The current prevalence of mobile phone technology and Internet access has increased the viability of remote health monitoring, thus presenting an opportunity to substantially improve the speed, convenience, and reliability of heart rate readings. Recent attention has focused on different methods for remote, non-contact heart rate measurement. Of these methods, video presents perhaps the best option for optimizing cost and convenience. This thesis introduces a lightweight architecture for estimating heart rate and HRV using a smartphone camera. The system presented here runs locally on a smartphone, requiring only a phone camera and 15s or more of continuous video of a subject’s face. No Internet connection or networking is necessary. Building the system to run locally in this manner means that this software confers benefits such as greater user privacy, offline availability, reliability, cost effectiveness, and speed. However, it also introduces added constraints on computational complexity. With these tradeoffs in mind, the system presented here is implemented within an Android mobile app. The performance of our approach fell short of that of existing state-of-the-art methods in terms of mean absolute error (MAE) of heart rate estimation, achieving MAE during validation that was over 17x
UNIQUENESS OF A

In this manuscript, we are concerned with the existence and uniqueness of the renormalized solution of a nonlinear elliptic problem β ( u ) − div a ( x,Du ) (cid:51) f in Ω, coupled with a Fourier boundary conditions a ( x,Du ) . η + λu = g on ∂ Ω, where f and g are functions of L 1 (Ω) and L 1 ( ∂ Ω) respectively. The functional setting involves Lebesgue and Sobolev spaces with variable exponent. Some a-priori estimates are used to obtain our results.
Combination of Osimertinib with Concurrent Chemotherapy and Hormonal Therapy for Synchronous NSCLC, Hormone Receptor-Positive Breast Cancer, and Triple-Negative Breast Cancer: Case Report

Patients presenting with multiple primary malignancies remain a growing challenge for physicians due to a lack of data for generalizable guidelines. Identification of driver mutations in carcinogenesis leads to the development of targeted treatment of many different cancer types, but its combination with other anti-cancer therapy is not well understood. We report a case of a 66-year-old woman who presented with triple-negative breast cancer, multifocal hormone receptor-positive breast cancer, primary epidermal growth factor receptor-mutated lung adenocarcinoma, possible primary lung adenocarcinoma of unspecified mutational status in the contralateral lung, and a solitary metastatic lesion in the brain from one of her primary cancers. She was treated with stereotactic radiosurgery and osimertinib in combination with carboplatin/nab-paclitaxel, doxorubicin/cyclophosphamide, and letrozole, with excellent clinical and radiographical response. We did not observe synergistic toxicity or unexpected adverse events from the treatment. To the best of our knowledge, this is the first report of concurrent osimertinib with these chemotherapy and hormonal therapy agents. As large-scale studies are difficult to conduct for these rare cases requiring exceptional treatment, it is important for physicians to build on the community’s shared experience via case reports to better predict efficacy and safety of combining targeted agents with other conventional systemic treatments.
Airborne Particles in Industrial Environments -Characteristics and Health Effects

• Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
The impact of mega events on construction planning, processes and performance – Auckland’s experience of the Rugby World Cup 2011

Internationally, mega events have been used by cities to enhance their image and improve urban spaces. Cities may be viewed as commodities, particularly when local or national governments are making the pitch for hosting rights of such events. As a commodity, they need to sell themselves, often requiring some change in the way they look and perform. New Zealand’s hosting of the Rugby World Cup (RWC) in 2011 created an opportunity for New Zealand to carry out much-needed improvements to the image of the country, the main cities, and Auckland in particular. Of the 48 World Cup games, 15 were held in Auckland, including the semi-finals and the final, as well as the opening and closing ceremonies for the event. The city required significant changes and improvements to local infrastructure, as well as expansion and upgrade of a number of venues, all within a relatively short space of time. This paper looks at some of the transformations that took place in Auckland in the lead up to the Rugby World Cup 2011, and explores the impacts of the event on planning processes and performance in the city. The paper first identifies the range of projects undertaken as part of the RWC upgrade in Auckland, and then focuses on the perceptions of seven industry representatives who were involved with key projects in the RWC development in Auckland. These individuals all participated closely in the planning and development processes of their respective projects. They have provided their reflections on how the RWC affected their projects, and lessons learnt in delivering within the context of such a mega event. The paper also briefly considers their perceptions of the social and economic impacts resulting from the RWC developments, and the opportunities lost and gained in the process.