Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigação do papel de HJURP (Holliday Junction Recognizing Protein) na resistência de células de glioblastoma multiforme à radiação ionizante

Glioblastoma multiforme (GBM) is the most common and lethal type of primary brain tumor, and usually leads the patient to death in approximately 14 months after diagnosis. The treatment consists of surgical removal of the tumor, followed by radiotherapy and chemotherapy. However, due to the high resistance of tumor cells, frequently the tumor grows again a few weeks after surgery. We recently demonstrated that HJURP (Holliday Junction Recognizing Protein), a novel protein involved in DNA repair, is highly overexpressed in glioblastoma cells. This protein is also overexpressed in other tumor types, such as lung and breast cancer, in which higher expression levels are correlated with a poorer survival prognosis, as we also observed for GBM patients. In this study we found that HJURP mRNA levels are increased in the GBM cell lines T98G, U138MG, U251MG e U343MG, while in U87MG cells HJURP levels are similar to that of non-tumoral fibrobalsts. We have also observed that the repair of DNA double-stranded breaks, induced by ionizing radiation, occurs similarly in GBM cells U138MG, U251MG and U343MG when HJURP is silenced or not. We also saw that U87MG and T98G cells were more sensitive to radiation when HJURP is knocked down, presenting higher rates of apoptosis and cell death. Moreover, we observed that HJURP silencing promotes premature senescence in the U87MG cell line, whereas T98G cells and non-tumoral fibroblasts are not significantly affected. Altogether, these data suggests that HJURP is related with the control of DNA repair activity and is required for the maintenance of GBM cells viability.
Crustal thickening versus lateral expulsion in the Indian‐Asian continental collision

Since the beginning of the continental collision between India and Asia there has been about 2500 km of convergence, and the northward movement of India has been accommodated by major internal deformation of the Asian lithosphere. The crustal thickening in and around the Tibetan Plateau is clearly a direct consequence of this collision, but there is considerable debate as to whether a large fraction of the indentation has been accommodated by eastward motion of the lithospheric blocks of southeastern Asia and southern China. Numerical experiments described here test this hypothesis for a range of indentation geometries and rheological models of the lithosphere. We employ a thin viscous sheet model of the lithosphere with a depth-averaged nonlinear viscous rheology described by a stress-strain rate exponent n and including gravitational buoyancy forces scaled by the dimensionless Argand number Ar. The eastern boundary for the collision region is described as a lithostatic boundary; the precollision normal stress is determined by static balance, and that constant stress is applied throughout the collision. The experiments show that during collision the eastern boundary is smoothly displaced to the east at a rate about 1/4 of the indentation rate, with only minor variation due to geometry or rheology. Crustal thickening rates in the region of the plateau are reduced by between 10% and 25% of the corresponding rates determined for similar experiments with a rigid eastern boundary. To generalize from the results of these experiments, the total north-south shortening strain produced by the collision is partitioned between crustal thickening and eastward displacement in the ratio of at least 3:1 and more probably 4:1.
Overview: understanding the links between agriculture and health

"Good health and productive agriculture are both essential in the fight against poverty. In a rapidly changing world, agriculture faces many challenges, both old (natural resource constraints, extreme weather conditions, and agricultural pests) and new (globalization, environmental degradation, problems of maintaining production in conflict situations). At the same time, new global health threats emerge, such as HIV/AIDS, SARS, and avian influenza, while old ones persist. Not only do malaria, tuberculosis, diarrheal diseases, respiratory infection, and malnutrition continue to take a heavy toll, but the health sector is faced with increasing problems of chronic disease, drug and insecticide resistance, and a diminishing arsenal of effective interventions. And as the world becomes more integrated, so do the agricultural and health problems the world faces. The briefs in this series aim to communicate what is known about the linkages between agriculture and health in science and policy, thereby stimulating interest in and dialogue on agriculture and health. With a focus on the poor in developing countries, the briefs deal with the relationship between agricultural producers, systems, and outputs and the world's leading causes of death and disease. They examine the various trade-offs involved and set out some of the approaches needed to create improved synergies between the agricultural and health sectors. " From text
The morphological and dynamical evolution of simulated galaxy clusters

We explore the morphological and dynamical evolution of galaxy clusters in simulations using scalar and vector-valued Minkowski valuations and the concept of fundamental plane relations. In this context, three questions are of fundamental interest: 1. How does the average cluster morphology depend on the cosmological background model? 2. Is it possible to discriminate between dierent cosmological models using cluster substructure in a statistically signicant way? 3. How is the dynamical state of a cluster, especially its distance from a virial equilibrium, correlated to its visual substructure? To answer these questions, we quantify cluster substructure using a set of morphological order parameters constructed on the basis of the Minkowski valuations (MVs). The dynamical state of a cluster is described using global cluster parameters: in certain spaces of such parameters fundamental band-like structures are forming indicating the emergence of a virial equilibrium. We nd that the average distances from these fundamental structures are correlated to the average amount of cluster substructure for our cluster samples during the time evolution. Furthermore, signicant dierences show up between the high- and the low-m models. We pay special attention to the redshift evolution of morphological characteristics and nd large dierences between the cosmological models even for higher redshifts.
Precise hypocenter distribution of deep low‐frequency earthquakes and its relationship to the local geometry of the subducting plate in the Nankai subduction zone, Japan

[1] We determine the precise hypocenter distribution of deep low-frequency earthquakes (LFEs) in the Nankai subduction zone and compare it with the local geometry of the subducting Philippine Sea plate. We apply a new hypocenter determination method utilizing the summed cross correlation coefficient over many stations, termed a network correlation coefficient (NCC), to 112 LFEs in the western Shikoku and 1566 LFEs in the whole Nankai subduction zone. While the catalog depths are widely distributed in some regions, the relocated hypocenters in every region construct a plane surface several km above the oceanic Moho interface and quite consistent with the geometry of the oceanic Moho. This result strongly supports the hypothesis that LFEs in the Nankai subduction zone occur on the subducting plate boundary and are directly generated by shear slips. If LFEs are indeed direct indicators of the locations of the plate interface, they might be useful to investigate the minute structure of the plate interface. The thin distributions of LFEs indicate that the interface between the subducting and the overriding plates is a distinct very thin boundary, and not a distributed shear zone.
An Errata for: Torsion subgroups of rational elliptic curves over the compositum of all $D_4$ extensions of the rational numbers

In [2], the author claims that the fields $\mathbb{Q}(D_4^\infty)$ defined in the paper and the compositum of all $D_4$ extensions of $\mathbb{Q}$ coincide. The proof of this claim depends on a misreading of a celebrated result by Shafarevich. The purpose is to salvage the main results of [2]. That is, the classification of torsion structures of $E$ defined over $\mathbb{Q}$ when base changed to the compositum of all $D_4$ extensions of $\mathbb{Q}$ main results of [2]. All the main results in [2] are still correct except that we are no longer able to prove that these two fields are equal.
Effects of Traffic Noise on the Social Behavior of Tufted Titmice (Baeolophus bicolor).

72 Introduction.73 Materials and methods.78 Results and discussion.86 Considerations, contributions and conclusions.92 xiv References.94 Appendices.105 Appendix A: Tables.106 Appendix B: Figures.109 III. CHAPTER 3: Traffic noise and dominance status increase chick-a-dee call rate and complexity in tufted titmice (Baeolophus bicolor). 114 Disclosure statement.115 Abstract.116 Introduction.117 Materials and methods.125 Results and discussion.133 Considerations, contributions and conclusions.142 References.144 Appendices.158 Appendix A: Tables.159 Appendix B: Figures.167 IV. CHAPTER 4: Rush hour traffic noise increases social behavior of tufted titmice (Baeolophus bicolor). 172 Disclosure statement.173 Abstract.174 Introduction.175 xv Materials and methods.179 Results and discussion.186 Considerations, contributions and conclusions.194 References.195 Appendices.200 Appendix A: Tables.201 Appendix B: Figures.205 V. CHAPTER 5: The effects traffic noise on tufted titmouse (Baeolophus bicolor) social behavior: Contributions, considerations and conclusions.211 Style and Scope.212 Contributions and implications of the current research.213 Considerations for future work.231 Concluding remarks.239 References.241 Appendices.260 Appendix A: Tables.261 VI. VITA.265
The digital complexity in destination branding: the case of Portugal as tourism destination

Tourism destinations are demanding strategic thinking and dynamic methods to address the contemporary digital challenge. The application of information communication technologies (ICTs) by tourism destinations, when correctly articulated with a destination branding strategy, could be a driving force to improve their strategic positioning, competitiveness, image and to optimise the benefits they derive from tourism. The novelty of this paper lies in the strategic approach to the digital complexity in destination branding by researching developments in branding Portugal as a tourism destination. A content analysis and text mining were applied as research methodology. Perceive how tourism-oriented promotional channels characterize destination Portugal, and further discuss the best branding strategies, is a central element along the study.
Getting Ahead: A Resident Led Quality Improvement Project to Increase Diabetic Nephropathy Screening in an Underserved Hispanic-Predominant Population

Introduction Diabetes is the leading cause of end-stage renal disease (ESRD) in the United States (US), with 37 million having chronic kidney disease. Despite national guidelines recommendations for diabetic nephropathy screening with urine albumin-to-creatinine ratio (UACR), less than 50% receive full screening. Our Internal Medicine residents led a quality improvement project to increase diabetic nephropathy screening rate with UACR in our resident clinic by 50% in one academic year. Methods We conducted the resident-led quality improvement project from July 2021 to April 2022. We reviewed the electronic medical records (EMR) from our clinic pre-intervention July 2020 to June 2021 and compared this to post intervention July 2021 to March 2022 determining the nephropathy screening rates in patients with diabetes. Our interventions included resident education, pre and post surveys to test foundational knowledge, adding UACR in the affordable laboratory order form and establishing normal reference range of UACR in the EMR. Results We collected 217 patients with diabetes, 27% were uninsured, 38% had Medicare/Medicaid and 90% identified as Hispanic. Comparing pre to post intervention, there was a significant change of 45 (20.7%) vs 71 (32.7%) patients screened for diabetic nephropathy with a UACR. The correct average score of knowledge-based questions was 82% on the pre survey, which increased to 88% in the post survey. Conclusion Our study showed promising results on improving diabetic nephropathy screening. The comprehensive approach including resident education about diabetic nephropathy screening with UACR and more so facilitating the order set in the EMR were key to achieve this goal.
A randomized Newton's method for solving differential equations based on the neural network discretization

We develop a randomized Newton's method for solving differential equations, based on a fully connected neural network discretization. In particular, the randomized Newton's method randomly chooses equations from the overdetermined nonlinear system resulting from the neural network discretization and solves the nonlinear system adaptively. We prove theoretically that the randomized Newton's method has a quadratic convergence locally. We also apply this new method to various numerical examples, from one- to high-dimensional differential equations, in order to verify its feasibility and efficiency. Moreover, the randomized Newton's method can allow the neural network to "learn" multiple solutions for nonlinear systems of differential equations, such as pattern formation problems, and provides an alternative way to study the solution structure of nonlinear differential equations overall.
Numerical analysis of rapid water transfer beneath Antarctica

Abstract We use a simple energy-conservation model and a model based on Röthlisberger’s theory for steady-state water flow in a subglacial conduit to model water movement between lakes in the Adventure subglacial trench region of East Antarctica during a 1996–98 jökulhlaup. Using available field evidence to constrain the models suggests that water flow would likely be accommodated in a tunnel with a cross-sectional area of 36 m2 and a value for k (the reciprocal of Manning’s roughness parameter) larger than the 12.5 m1/3 s−1 previously calculated. We also use Nye’s theory for time-dependent conduit water flow to model the temporal evolution of conduit discharge, cross-sectional area, water pressure and lake draining and filling during the flood. We initially assume one source and one sink lake. We perform sensitivity tests on the input parameter set, matching modeled source- and sink-lake depth changes with measured surface elevation data. Using a simple function for vertical ice deformation in which surface deformation scales linearly to the lake depth change, we find the scaling factor is of the order 4 × 10−3 of the ice thickness. The most likely value of k lies in the range 55–68 m1/3 s−1, and the ratio of source to sink-lake radii is approximately 1 : 1.4. Finally, we experiment using Nye’s theory to model water movement between one source and three sink lakes. The model fails to produce the observed patterns of water movement as indicated by the surface deformation data.
Codegree Turán Density of Complete r-Uniform Hypergraphs

Let $r\ge 3$. Given an $r$-graph $H$, the minimum codegree $\delta_{r-1}(H)$ is the largest integer $t$ such that every $(r-1)$-subset of $V(H)$ is contained in at least $t$ edges of $H$. Given an $r$-graph $F$, the codegree Tur\'an density $\gamma(F)$ is the smallest $\gamma >0$ such that every $r$-graph on $n$ vertices with $\delta_{r-1}(H)\ge (\gamma + o(1))n$ contains $F$ as a subhypergraph. Using results on the independence number of hypergraphs, we show that there are constants $c_1, c_2>0$ depending only on $r$ such that \[ 1 - c_2 \frac{\ln t}{t^{r-1}} \le \gamma(K_t^r) \le 1 - c_1 \frac{\ln t}{t^{r-1}}, \] where $K_t^r$ is the complete $r$-graph on $t$ vertices. This gives the best general bounds for $\gamma(K_t^r)$.
Remote sensing evidence for baroclinic tide origin of internal solitary waves in the northeastern South China Sea

Evidence for baroclinic tide origin of internal solitary waves (ISWs) in the northeastern South China Sea is presented, based on 116 internal wave packets observed in satellite images from 1995 to 2001. These wave packets can be divided into two types, a single‐wave ISW packet containing only one ISW with/without an oscillating tail, and a multiple‐wave ISW packet composed of a group of rank‐ordered ISWs. All of the 22 single‐wave ISW packets occur in the deep water zone. It is suggested that the ISWs, instead of being generated by the lee‐wave mechanism, are developed by nonlinear steepening of the baroclinic tides, which are produced by the strong tidal currents flowing over a ridge in Luzon Strait. This suggestion is verified by an ERS‐2 SAR image, which records such an evolution process from a baroclinic tide to a single ISW in its spatial domain.
Linear behavior of the optical conductivity and incoherent charge transport in 
BaCoS2

Optical conductivity measurements on a BaCoS2 single crystal show an unusual linear behavior over a broad spectral range, which contradicts the previously proposed scenario of a charge-transfer Mott insulator. Ab initio dynamical mean field theory calculations including a retarded Hubbard interaction explain the data in terms of an incipient opening of a Co(3d)-S(3p) charge-transfer gap concomitant to incoherent charge transport driven by electronic correlations. These results point towards a non-Fermi liquid scenario with Hund's metal properties, which arises from an incipient Mott phase destabilized by strong low-energy charge fluctuations across the vanishing 3d-3p charge transfer gap.
Explicit formulas for real hyperelliptic curves of genus 2 in affine representation

In this paper, we present for the first time efficient explicit formulas for arithmetic in the degree 0 divisor class group of a real hyperelliptic curve. Hereby, we consider real hyperelliptic curves of genus 2 given in affine coordinates for which the underlying finite field has characteristic > 3. These formulas are much faster than the optimized generic algorithms for real hyperelliptic curves and the cryptographic protocols in the real setting perform almost as well as those in the imaginary case. We provide the idea for the improvements and the correctness together with a comprehensive analysis of the number of field operations. Finally, we perform a direct comparison of cryptographic protocols using explicit formulas for real hyperelliptic curves with the corresponding protocols presented in the imaginary model.
Unique Normal Forms in Infinitary Weakly Orthogonal Term Rewriting

We p resent some contributions to the theory of infinitary rewriting for weakly orthogonal term rewrite systems, in which critical pairs may occur provided they are trivial. We show that the infinitary unique normal form property (UN ∞ ) fails by a simple ex- ample of a weakly orthogonal TRS with two collapsing rules. By translating this example, we show that UN ∞ also fails for the infinitary ���-calculus. As positive results we obtain the following: Infinitary confluence, and hence UN ∞ , holds for weakly orthogonal TRSs that do not contain collapsing rules. To this end we refine the compression lemma. Furthermore, we consider the triangle and diamond properties for infinitary multi-steps (complete developments) in weakly orthogonal TRSs, by refining an earlier cluster-analysis for the finite case.
Dispersion of artificial caesium-134 and -137 in the western North Pacific one month after the Fukushima accident

(about 85 PBq) (WHO, 1989). Large amounts of water to cool the fuel rods was supplied and this procedure increased the amount of water contaminated with radionuclides, and the contaminated water leaked onto the land and into the ocean. By early April (end of May), the estimated total amount of accidentally and deliberately emitted 137Cs was 2.6 (3.5 ± 0.7) PBq (Tsumune et al., 2011). The maximum 137Cs concentrations at the north drain outlet of the plant and at 30 km off Fukushima were 68,000 Bq L–1 (on 30 March: TEPCO, 2011a) and 186 Bq L–1 (on 15 April: MEXT, 2011), respectively. Thereafter, these concentrations have been decreasing, but the level of radioactivity in seawater is still higher than the background level due to the atmospheric nuclear weapons test before 11 March (MOE, 2009). Moreover, about 0.11 million tons of radioactivity-contaminated water (total radioactivity, 720 PBq, including 137Cs, 140 PBq) had Dispersion of artificial caesium-134 and -137 in the western North Pacific one month after the Fukushima accident
Distributed adaptive algorithm based on the asymmetric cost of error functions

In this paper, a family of novel diffusion adaptive estimation algorithm is proposed from the asymmetric cost function perspective by combining diffusion strategy and the linear-linear cost (LLC), quadratic-quadratic cost (QQC), and linear-exponential cost (LEC), at all distributed network nodes, and named diffusion LLCLMS (DLLCLMS), diffusion QQCLMS (DQQCLMS), and diffusion LECLMS (DLECLMS), respectively. Then the stability of mean estimation error and computational complexity of those three diffusion algorithms are analyzed theoretically. Finally, several experiment simulation results are designed to verify the superiority of those three proposed diffusion algorithms. Experimental simulation results show that DLLCLMS, DQQCLMS, and DLECLMS algorithms are more robust to the input signal and impulsive noise than the DSELMS, DRVSSLMS, and DLLAD algorithms. In brief, theoretical analysis and experiment results show that those proposed DLLCLMS, DQQCLMS, and DLECLMS algorithms have superior performance when estimating the unknown linear system under the changeable impulsive noise environments and different types of input signals.
Seasonal changes in bathyal foraminiferal populations in response to the flux of organic matter (Sagami Bay, Japan)

Benthic foraminiferal populations through 1991–94 were investigated by taking cores and in situ observations from the submersible Shinkai 2000 in Sagami Bay, Japan (1450 m water depth). At this location, a strong spring bloom causes seasonal deposition of phytodetrital material to the sea floor. The population size of benthic foraminifera is mainly controlled by this seasonal flux of organic matter, which triggers rapid, opportunistic reproduction of the shallow infaunal taxa Bolivia pacifica and Textularia kattegatensis. We propose that these species have a one‐year life cycle. The deep infaunal taxa Globobulimina affinis and Chilostomella ovoidea show less pronounced seasonal fluctuations in population size, and seem to have a life cycle longer than two years. The foraminifera migrate vertically through the sediment, down to the maximum depth to which the sediment is oxygenated. The seasonal flux of organic matter thus is the most important determinant of population size, microhabitats, and reproduction in Sagami Bay. Such foraminifera are extremely relevant in the functioning of the global carbon cycle, especially at the interface of the hydrosphere and lithosphere.
OptQC: An optimised parallel quantum compiler

The software package \emph{Qcompiler} (CPC, 184 (2013) 853) provides a general quantum compilation framework, which maps any given unitary operation into a quantum circuit consisting of a sequential set of elementary quantum gates. In this paper, we present an extended software \emph{OptQC}, which finds permutation matrices $P$ and $Q$ for a given unitary matrix $U$ such that the number of gates in the quantum circuit of $U = Q^TP^TU'PQ$ is significantly reduced, where $U'$ is equivalent to $U$ up to a permutation and the quantum circuit implementation of each matrix component is considered separately. We extend further this software package to make use of high-performance computers with a multiprocessor architecture using MPI. We demonstrate its effectiveness in reducing the total number of quantum gates required for various unitary operators.