Miracle-dz/UniFAR-FTUs huggingface dataset:
Replication of the association between variants in the WFS1 gene and risk of type 2 diabetes in European populations

Aims/hypothesis: Mutations at the Wolframin encoding gene, WFS1, cause Wolfram syndrome, a rare neurological condition. Associations between single nucleotide polymorphisms (SNPs) at WFS1 and type 2 diabetes have recently been reported. In the present study, we sought to replicate those associations in a northern Swedish case-control study for type 2 diabetes. We also meta-analyzed published and previously unpublished data from Sweden, Finland and France to obtain updated summary effect estimates. Methods: Four WFS1 SNPs (rs10010131, rs6446482, rs752854, rs734312 [R611H]) were genotyped in a type 2 diabetes case-control study (N=1,296/1,412) of Swedish adults. Logistic regression was used to assess the association between each WFS1 SNP and type 2 diabetes, following adjustment for age, sex, and body mass index. We then performed a meta-analysis of 11 studies of type 2 diabetes, comprising up to 14,139 cases and 16,109 controls, to obtain a summary effect estimate for the WFS1 variants. Results: In the northern Swedish study, the minor allele at rs752854 was associated with reduced type 2 diabetes risk (OR=0.85; 95% CI=0.75-0.96; p=0.010). Borderline statistical associations were observed for the remaining SNPs. The meta-analysis of the four independent replication studies for SNP rs10010131, or its proxy variants, showed evidence for statistical association (OR=0.87; 95% CI=0.82-0.93; p=4.5×10 −5 ). In an updated meta-analysis of all 11 studies, comprising 14,139 cases and 16,109 controls, strong evidence for statistical association was also observed (OR=0.89; 95% CI=0.86-0.92; p=4.9×10 −11 ). Conclusion: In this study of WFS1 gene variants and type 2 diabetes risk, we have replicated the previously reported associations between SNPs at this locus and risk of type 2 diabetes.
J-Holomorphic Curves and Quantum Cohomology

Introduction Local behaviour Moduli spaces and transversality Compactness Compactification of moduli spaces Evaluation maps and transversality Gromov-Witten invariants Quantum cohomology Novikov rings and Calabi-Yau manifolds Floer homology Gluing Elliptic regularity Bibliography Indexes.
Densest Subgraph Discovery on Large Graphs: Applications, Challenges, and Techniques

As one of the most fundamental problems in graph data mining, the densest subgraph discovery (DSD) problem has found a broad spectrum of real applications, such as social network community detection, graph index construction, regulatory motif discovery in DNA, fake follower detection, and so on. Theoretically, DSD closely relates to other fundamental graph problems, such as network flow and bipartite matching. Triggered by these applications and connections, DSD has garnered much attention from the database, data mining, theory, and network communities. In this tutorial, we first highlight the importance of DSD in various applications and the unique challenges that need to be addressed. Subsequently, we classify existing DSD solutions into several groups, which cover around 50 research papers published in many well-known venues (e.g., SIGMOD, PVLDB, TODS, WWW), and conduct a thorough review of these solutions in each group. Afterwards, we analyze and compare the models and solutions in these works. Finally, we point out a list of promising future research directions. We believe that this tutorial not only helps researchers have a better understanding of existing densest subgraph models and solutions, but also provides them insights for future study.
Molecular lymph node status for prognostic stratification of prostate cancer patients 1 undergoing radical prostatectomy with extended pelvic lymph node dissection head: Molecular lymph node analysis in prostate cancer

(250 of max. 250 Words) Purpose: Molecular lymph node (LN) analysis using quantitative polymerase chain reaction (qPCR) detects LN metastases with higher sensitivity than histopathology. However, the prognostic role of molecular LN status in prostate cancer (PCa) 56 patients treated with radical prostatectomy (RP) and extended pelvic LN dissection 57 (ePLND) is unclear. To investigate the association of molecular compared to 58 histopathologic LN status with biochemical recurrence. Experimental Design: Patients with intermediate and risk PCa were prospectively enrolled and underwent RP with ePLND including obturator, internal, 61 external and common iliac region. LNs ≥3mm were bisected and examined by standard histopathology and qPCR for Kallikrein3 (KLK3) expression. Biochemical recurrence was defined by confirmed postoperative PSA>0.2ng/ml. Results: In 111 patients, 2411 of 3173 removed LNs were examined by both 65 methods. Histopathology detected 68 LN metastases in 28 (25%) patients. Molecular analysis confirmed elevated KLK3 expression in 65 histopathologic LN metastases of all 28 pN1-patients (pN1/molN1) and additionally reclassified 224 histopathologic negative LNs and 32 (29%) pN0-patients as LN-positive (pN0/molN1).
Speci ﬁ city and 6-Month Durability of Immune Responses Induced by DNA and Recombinant Modi ﬁ ed Vaccinia Ankara Vaccines Expressing HIV-1 Virus-Like Particles

Background . Clade B DNA and recombinant modi ﬁ ed vaccinia Ankara (MVA) vaccines producing virus-like particles displaying trimeric membrane-bound envelope glycoprotein (Env) were tested in a phase 2a trial in human immunode ﬁ ciency virus (HIV) – uninfected adults for safety, immunogenicity, and 6-month durability of immune responses. Methods . A total of 299 individuals received 2 doses of JS7 DNAvaccine and 2 doses of MVA/HIV62B at 0, 2, 4, and 6 months, respectively (the DDMM regimen); 3 doses of MVA/HIV62B at 0, 2, and 6 months (the MMM regimen); or placebo injections. Results . At peak response, 93.2% of the DDMM group and 98.4% of the MMM group had binding antibodies for Env. These binding antibodies were more frequent and of higher magnitude for the transmembrane subunit (gp41) than the receptor-binding subunit (gp120) of Env. For both regimens, response rates were higher for CD4 + T cells (66.4% in the DDMM group and 43.1% in the MMM group) than for CD8 + T cells (21.8% in the DDMM group and 14.9% in the MMM group). Responding CD4 + and CD8 + T cells were biased toward Gag, and >70% produced 2 or 3 of the 4 cytokines evaluated (ie, interferon γ , interleukin 2, tumor necrosis factor α , and granzyme B). Six months after vaccination, the magnitudes of antibodies and T-cell responses had decreased by <3-fold. Conclusions . DDMM and MMM vaccinations with virus-like particle – expressing immunogens elicited durable antibody and T-cell responses.
Houdmont, Jonathan and Zhou, Jieming and Hassard, Juliet (2011) Overtime and psychological well-being

Background: Research on the relationship between overtime and psychological well-being, and workers’ perceptions of the factors that determine overtime, has been conducted exclusively in the Western cultural context. Aims: To examine whether existing theory and evidence can be applied to a non-Western cultural setting by investigating the constructs among a sample of office workers drawn from a Chinese branch of an international information and communication technology company. Methods: Data were collected from 130 full-time employees on overtime hours worked, psychological well-being, and four variables identified by participants as being important determinants of overtime: job demands, intrinsic motivation, anticipated rewards, and overtime work culture. T-tests and multiple linear regression analyses were used to examine the relationship between variables. Results: All study participants had worked overtime in the previous 6 months period; the mean weekly overtime rate was 14.2 h. High overtime employees demonstrated significantly lower levels of psychological well-being than those who worked low levels of overtime. In combination, the four reasons for working overtime predicted approximately one-fifth of the variance in overtime hours worked, suggesting that knowledge of these variables could be used by practitioners to predict the amount of overtime in which workers are likely to engage. Conclusions: The findings suggest that existing theory and evidence may apply beyond the individualist cultural context. The findings might usefully inform the organization of work in collectivist cultures and the implementation of multinational operations in these cultures.
VHRM_A_242635 577..589

1Cátedra de Farmacología Aplicada, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Argentina; 2Servicio de Terapia Intensiva, Sanatorio Otamendi, Buenos Aires, Argentina Abstract: Microcirculation is a particular organ of the cardiovascular system. The goal of this narrative review is a critical reappraisal of the present knowledge of microcirculation monitoring, mainly focused on the videomicroscopic evaluation of sublingual microcirculation in critically ill patients. We discuss the technological developments in handheld videomicroscopy, which have resulted in adequate tools for the bedside monitoring of microcirculation. By means of these techniques, a large body of evidence has been acquired about the role of microcirculation in the pathophysiological mechanisms of shock, especially septic shock. We review the characteristics of sublingual microcirculation in septic shock, which mainly consist in a decrease in the perfused vascular density secondary to a reduction in the proportion of perfused vessels along with a high heterogeneity in perfusion. Even in patients with high cardiac output, red blood cell velocity is decreased. Thus, hyperdynamic flow is absent in the septic microcirculation. We also discuss the dissociation between microcirculation and systemic hemodynamics, particularly after shock resuscitation, and the different behavior among microvascular beds. In addition, we briefly comment the effects of some treatments on microcirculation. Despite the fact that sublingual microcirculation arises as a valuable goal for the resuscitation in critically ill patients, significant barriers remain present for its clinical application. Most of them are related to difficulties in video acquisition and analysis. We comprehensively analyzed these shortcomings. Unfortunately, a simpler approach, such as the central venous minus arterial PCO2 difference, is a misleading surrogate for sublingual microcirculation. As conclusion, the monitoring of sublingual microcirculation is an appealing method for monitoring critically ill patients. Nevertheless, the lack of controlled studies showing benefits in terms of outcome, as well as technical limitations for its clinical implementation, render this technique mainly as a research tool.
islaMic banKs before value- based interMediation iMpleMentation

Bank Negara Malaysia (BNM) had introduced Value-Based Intermediation (VBI) initiatives to help Islamic banks implement a structuralised form of maqasid al-shariah (objectives of shariah (Islamic law)) in their banking operations. Thus, questions were raised by the public on whether or not Islamic banking institutions in Malaysia had been achieving maqasid al-shariah in their banking operations prior to VBI. This paper aims to discuss the real concept of maqasid al-shariah that should be realised in Islamic banks and investigate whether Islamic banks had truly been achieving maqasid al-shariah in their banking operations before the introduction of VBI. Library research is conducted to obtain information on maqasid al-shariah and the qualitative methodology is adopted to gain information from three bankers representing three Islamic banks in Malaysia via semi-structured interviews. The researchers found that the fundamental concept of maqasid other than their understanding on maqasid al-shariah.
University of Southern Denmark Do different types of bearings and noise from total hip arthroplasty influence hip-related pain, function, and quality of life postoperatively? A cross-sectional study from the Danish Hip Arthroplasty Registry

Citation for pulished version (APA): Varnum, C. , Pedersen, A. B. , Kjærsgaard-Andersen, P., & Overgaard, S. (2016). Do different types of bearings and noise from total hip arthroplasty influence hip-related pain, function, and quality of life postoperatively? A cross-sectional study from the Danish Hip Arthroplasty Registry. Acta Orthopaedica, 87(6), 567-574. https://doi.org/10.1080/17453674.2016. 1225649
Halophilic Bacteria: Diversity and Biotechnological Applications

- Hypersaline environments are extreme habitats on the planet and have a diverse microbial population formed by halophilic microorganisms. They are considered to be actual or potential sources for discovery bioactive compounds, compatible solutes including novel and/or extraordinarily enzymes. To date, a number of bioactive compounds for the use in various fields of biotechnology which show assorted biological activities ranging from antioxidant, sunscreen and antibiotic actions have been reported. In addition, some halophilic microorganisms are capable of producing massive amounts of compatible solutes that are useful as stabilizers for biomolecules or stress-protective agents. The present review will impart knowledge and discuss on diversity of halophilic bacteria and their use in various biotechnological applications, including industrial, pharmaceutical, agricultural and environmental aspects. Culture dependent as well as culture independent methods for isolation of halophiles should go hand in hand to provide the insight mechanisms of halophilic adaptation and their future applications.
The Relationship between Academic Achievement and Physical Fitness in Preadolescent Children / Povezanost akademskih postignuća i tjelesnoga fitnesa kod djece u predadolescentnoj dobi

The purpose of the study was to determine whether students differ in terms of their physical fitness according to their academic achievements in mathematics, language (Slovene) and PE. The sample comprised 467 participants: 250 males and 217 females. In order to assess physical fitness levels, eight different tests from the Eurofit test battery were conducted. The academic performance of children was defined on the basis of three criteria: final grades in mathematics, final grades in Slovene language and final grades in the subject of sports. An independent t-test and a multiple regression analysis were performed to determine the relationship between various physical fitness tests and academic achievement. The most important finding of our study is that physical fitness is related to academic achievement in preadolescent children. Children with better academic achievements performed better in most physical fitness tests than peers who had poorer academic performance. Key words: childhood; motor abilities; school grades. Â ---Â Svrha studije bila je utvrditi razlikuju li se djeca u pogledu tjelesnoga fitnesa u skladu s njihovim akademskim uspjehom iz matematike, jezika (slovenski jezik) i tjelesne i zdravstvene kulture. Uzorak je obuhvaćao 467 sudionika: 250 dječaka i 217 djevojčica. Kako bi se procijenila razina tjelesnoga fitnesa, provedeno je osam različitih testova iz testne baterije Eurofit. Akademski uspjeh djece definiran je na temelju tri kriterija: završne ocjene iz Matematike, završne ocjene iz Slovenskog jezika i završne ocjena iz Tjelesne i zdravstvene kulture. Izvedeni su neovisni t-test i višestruka regresijska analiza kako bi se utvrdio odnos između različitih testova tjelesnoga fitnesa i akademskoga uspjeha. Najvažniji nalaz našega istraživanja jest da je tjelesni fitnes povezan s akademskim uspjehom kod djece u predadolescentnoj dobi. Djeca s boljim akademskim uspjehom pokazala su bolje rezultate na većini testova tjelesnoga fitnesa u usporedbi s vršnjacima koji su imali slabiji akademski uspjeh. Ključne riječi: djetinjstvo; tjelesne sposobnosti; školske ocjene.
Theseus: Navigating the Labyrinth of Time-Series Anomaly Detection

The detection of anomalies in time series has gained ample academic and industrial attention, yet, no comprehensive benchmark exists to evaluate time-series anomaly detection methods. Therefore, there is no final verdict on which method performs the best (and under what conditions). Consequently, we often observe methods performing exceptionally well on one dataset but surprisingly poorly on another, creating an illusion of progress. To address these issues, we thoroughly studied over one hundred papers, and summarized our effort in TSB-UAD, a new benchmark to evaluate univariate time series anomaly detection methods. In this paper, we describe Theseus, a modular and extensible web application that helps users navigate through the benchmark, and reason about the merits and drawbacks of both anomaly detection methods and accuracy measures, under different conditions. Overall, our system enables users to compare 12 anomaly detection methods on 1980 time series, using 13 accuracy measures, and decide on the most suitable method and measure for some application.
UPLIFT: Parallelization Strategies for Feature Transformations in Machine Learning Workloads

Data science pipelines are typically exploratory. An integral task of such pipelines are feature transformations, which transform raw data into numerical matrices or tensors for training or scoring. There exist a wide variety of transformations for different data modalities. These feature transformations incur large computational overhead due to expensive string processing and dictionary creation. Existing ML systems address this overhead by static parallelization schemes and interleaving transformations with model training. These approaches show good performance improvements for simple transformations, but struggle to handle different data characteristics (many features/distinct items) and multi-pass transformations. A key observation is that good parallelization strategies for feature transformations depend on data characteristics. In this paper, we introduce UPLIFT, a framework for P aralle LI zing F eature T ransformations. UPLIFT constructs a fine-grained task graph for a set of transformations, optimizes the plan according to data characteristics, and executes this plan in a cache-conscious manner. We show that the resulting framework is applicable to a wide range of transformations. Furthermore, we propose the FTBench benchmark with transformations and datasets from various domains. On this benchmark, UPLIFT yields speedups of up to 31.6x (9.27x on average) compared to state-of-the-art ML systems.
DMSO_A_286565 4919..4927

*These authors contributed equally to this work Background: To determine the optimal cut-off values and evaluate the associations of product of triacylglycerol and glucose (TyG), lipid accumulation product (LAPI), visceral adiposity index (VAI) with chronic kidney diseases (CKD) stratified by sex. Methods: From January to April 2018, our team had conducted a large-scale cross-sectional survey that contained 2720 individuals on the southern coast of China. Logistic regression analysis and receiver operating characteristic (ROC) analyses were used to evaluate the optimal cut-off and value of TyG, LAPI, VAI for predicting CKD. Results: A multivariate logistic regression analysis found that the TyG had the better value of prediction for the presence of CKD for the highest quartile vs the lowest quartile in both males (OR: 3.65; 95% CI, 2.04–6.52; p<0.001) and females (OR: 3.50; 95% CI, 2.20–5.56; p<0.001), followed by LAPI and VAI, when further adjusted for cofounder factors, LAPI and VAI both lost their independence, and only TyG remains its significant association with CKD in both males (OR: 2.81; 95% CI, 1.25–6.30; p<0.001) and females (OR: 3.22; 95% CI, 1.56–6.61; p<0.001). ROC curve showed that TyG had the highest AUC for predicting CKD in males (AUC: 0.618). TyG (AUC: 0.670) and LAPI (AUC: 0.670) both had the highest AUC in females. United predicted models which contain TyG were conducted for predicting CKD in males (AUC: 758) and females (AUC: 0.773) and results indicated that multivariate analysis of TyG and other traditional factors can impressively improve the accuracy of predictive probability for CKD. Conclusion: TyG is a priority to the other two novel indices and may become valuable makers and have strong predictive power for predicting CKD, especially in females.
Impact of Foliar Application with Iron, Zinc, Silicon Nano Particles and Yeast on Growth, Yield and Water Use Efficiency of Tomato Plants under Water Stress Conditions

Two filed experiments were conducted during the two summer seasons of 2015 and 2016 in a private Farm at Gemiana village near Belqas City Dakahlia Governorate, Egypt, to study the effect of interaction between deficit irrigation water (60%, 80%, 100% of ETc) and some foliar spray treatments (nano iron, nano zinc, nano silicon and yeast extract) on plant growth parameters, chemical composition of leaves as photosynthetic pigments (Chl. a, Chl. b, total Chl. a+b), leaf mineral percentages (N, P, K) proline, yield and water use efficiency (WUE) of tomato plants (Fayruz hybrid) under drip irrigation system. A strip-plot design with three replicates was used. The vertical plots were allocated to the deficit irrigation, whereas the horizontal-plots were devoted to foliar spray treatments. Results revealed that the interaction among irrigation tomato plants at the level of 80 % Etc and spraying with different nano particles at different concentration or yeast extract significantly increased all aforementioned parameters, meanwhile deficit irrigation water treatments improved leaves proline content and WUE in both growing seasons. The best interaction treatment for increasing plant growth parameters, chemical constitutes of leaves as photosynthetic pigments (Chl. a, Chl. b, total Chl. a+b) leaf mineral percentages (N, P, K) early and total yield is irrigation treatment with 80 % Etc and spraying with nano Si at 12 ppm and can be recommended to increase growth and productivity tomato plants of under similar conditions of this study.
ReviewImmunomodulatory Effects of IL-

The type I cytokine family members interleukin-2 (IL-2) and IL-15 play important roles in the homeostasis of innate and adaptive immunity. Although IL-2 and IL-15 receptor complexes activate similar signal transduction cascades, triggering of these receptors results in different functional activities in lymphocytes. While IL-2 expands regulatory T cells and CD4+ helper T cells, IL-15 supports the development of central memory T cells and NK cells. Recent data have provided evidence that IL-2 and IL-15 differ in their ability to activate T and NK cells to resist various forms of immune suppression. The diverse roles of these two cytokines have on immune cells lead to critical therapeutic implications for cancer treatment. In this review, we discuss the distinct roles of IL-2 and IL-15 in activating various functions in T and NK cells with a particular focus on the signals that participate in the resistance of tumor-derived immune suppressive factors. Furthermore, we summarize current clinical applications of IL-2 and IL-15 in metastatic malignancies, either as monotherapy or in combination with other agents, and highlight the future trends for research on these cytokine-based immunotherapies.