Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Health Intervention via Web-Based Education on Improving Information-Motivation-Behavioral Skills Related to HPV Vaccination Among Chinese Female College Students

Objectives: The human papillomavirus (HPV) vaccination rate is generally low in China. This study aimed to assess the effect of web-based education on improving information-motivation-behavior skills related to HPV vaccination among Chinese female college students. Methods: From February to May 2020, female students were recruited from a university and divided into intervention and control groups. The intervention group received 7 days of HPV-related web-based education. Related information were collected using questionnaires in the baseline, 7 days, 1 month, and 3 months after the intervention. Chi-square test and repeated ANOVA were used to compare the differences between the two groups in the four surveys. Results: A total of 449 students (235 in the intervention and 214 in the control group) were included in the analysis. There were no statistical differences in demographic information between the two groups. Compared with the control group, students in the intervention group showed a richer knowledge and subjective norms of HPV vaccination (p < 0.05). Conclusion: The study provides preliminary support for a health intervention via web-based education in increasing HPV vaccination information among female college students.
Is mushroom polysaccharide extract a better fat replacer than dried mushroom powder for food applications?

Introduction β-glucans found in the cell walls of mushrooms can be a beneficial food additive in replacing fat in commercial food products. Methods Four commonly consumed mushroom species in Singapore, i.e., Pleurotus ostreatus spp. , Lentinus edodes, Agaricus bisporus, and Flammulina velutipes were profiled for the β-glucan content in the lyophilized form and ultrasonicated assisted extracted form. Both forms were added into chicken patties, which were characterized for the moisture, cooking loss, texture, color, and chemically analyzed for the protein, crude fat, and fatty acid profiles with gas chromatography mass spectrometry (GC-MS). Results and discussion Pleurotus Ostreatus spp. had the highest β-glucan of 29.8 ± 0.7 g/100 g in the pure powder form and 15.9 ± 0.3 g/100 g from the extract. Crude fat in 100% fat substituted patties was lowest in Flammulina velutipes extract enriched patties and least in A. bisporus pure powder patties. Additionally, fat replacement with A. bisporus extract and powder forms resulted in the highest polyunsaturated fatty acid profile of 49.6 ± 1.9 mg/100 g patty and 79.9 ± 4.5 mg/100 g patty, respectively. Chicken patties with added mushroom extract were notable in retaining moisture, cooking yield and its structure. Fat substitution with mushroom powder was also conducted, satisfactory results indicated a possibility as a better fat replacer that is easily processed and an efficient alternative to β-glucan extract. With increasing demand for low fat foods with acceptable organoleptic properties, our study demonstrates that the inclusion of dry mushroom powder has the ability to mimic the “fattiness” of chicken patties.
Silicon in action: Between iron scarcity and excess copper

Essential micronutrients belonging to the transition metals, such as Fe and Cu, are indispensable for plant growth and stress tolerance; however, when present in excess, they can become potentially dangerous producers of reactive oxygen species. Therefore, their homeostases must be strictly regulated. Both microelement deficiencies and elevated concentrations of heavy metals in the soil are global problems that reduce the nutritional value of crops and seriously affect human health. Silicon, a beneficial element known for its protective properties, has been reported to alleviate the symptoms of Cu toxicity and Fe deficiency stress in plants; however, we are still far from a comprehensive understanding of the underlying molecular mechanisms. Although Si-mediated mitigation of these stresses has been clearly demonstrated for some species, the effects of Si vary depending on plant species, growing conditions and experimental design. In this review, the proposed mechanistic models explaining the effect of Si are summarized and discussed. Iron and copper compete for the common metal transporters and share the same transport routes, hence, inadequate concentration of one element leads to disturbances of another. Silicon is reported to beneficially influence not only the distribution of the element supplied below or above the optimal concentration, but also the distribution of other microelements, as well as their molar ratios. The influence of Si on Cu immobilization and retention in the root, as well as Si-induced Fe remobilization from the source to the sink organs are of vital importance. The changes in cellular Cu and Fe localization are considered to play a crucial role in restoring homeostasis of these microelements. Silicon has been shown to stimulate the accumulation of metal chelators involved in both the mobilization of deficient elements and scavenging excess heavy metals. Research into the mechanisms of the ameliorative effects of Si is valuable for reducing mineral stress in plants and improving the nutritional value of crops. This review aims to provide a thorough and critical overview of the current state of knowledge in this field and to discuss discrepancies in the observed effects of Si and different views on its mode of action.
The carbon footprint of young-beef cattle finishing systems in the Eastern Plains of the Orinoco River Basin of Colombia

Introduction Previous research has shown increased productivity amongst sown grass pastures compared to native savanna pastures by year-round grazing for fattening of adult and young Brahman (Bos indicus)-bred cattle in the well-drained native savanna ecosystem of the Colombian Orinoquía. But there is limited information on the carbon footprint (CF) of commercial young-Brahman heifers and steers reared throughout life on well-managed Brachiaria decumbens Stapf pastures. Methods The present study characterized growth, lifetime enteric methane (CH4) emissions, carcass carbon dioxide equivalent (CO2-eq) CH4 efficiency intensities (i.e., emissions per kg of product), and estimated the overall CF of young cattle grazing B. decumbens pastures subject to a range of daily liveweight gains (DLWGs; 0.428 – 0.516 kg) and fattening framework (405 – 574 kg). Weaning data from seven consecutive calving seasons in a commercial Brahman breeding herd continuously grazed on B. decumbens were integrated with a Microsoft Excel® dynamic greenhouse gas emission (GHGE) simulation of stockers-yearlings, and seven fattening, and processing scenarios. Results The model predicted that heifers subject to low and high DLWGs (0.428 vs 0.516 kg) and steers (0.516 kg) may be successfully fattened without supplementation assuming that animals had access to a well-managed grass pasture. Depending on the fattening strategy, kg CO2-eq CH4/kg edible protein values ranged from 66.843 to 87.488 ± 0.497 for heifers and from 69.689 to 91.291 ± 0.446 for steers. Discussion Assuming that forage on offer is at least 1,500-2,000 kg of dry matter/ha during the rainy season, all the simulated systems showed potential for C neutrality and net-zero C emission when considering GHGEs from the soil, pasture, and animal components vs the estimated soil C capture over seven seasons. However, under a more optimistic scenario, these beef systems could accomplish substantial net gains of soil C, over the period for which field data are available. Overall, this study projects the positive impact of the design of plausible fattening strategies on grasslands for improving cattle productivity and reducing emission intensities with concomitant increases in technical efficiency.
Protein arginine methyltransferases in renal development, injury, repair, and fibrosis

Protein arginine methyltransferases (PRMTs) methylate a range of histone and non-histone substrates and participate in multiple biological processes by regulating gene transcription and post-translational modifications. To date, most studies on PRMTs have focused on their roles in tumors and in the physiological and pathological conditions of other organs. Emerging evidence indicates that PRMTs are expressed in the kidney and contribute to renal development, injury, repair, and fibrosis. In this review, we summarize the role and the mechanisms of PRMTs in regulating these renal processes and provide a perspective for future clinical applications.
Research or teaching? That is the problem: A narrative inquiry into a Chinese college English teacher’s cognitive development in the teaching-research nexus

This narrative inquiry traces a Chinese college English teacher’s cognitive transformation in the teaching-research nexus over a 4-year time period from the perspective of sociocultural theory (SCT). Several stories were narrated based on the data from reflective journals, literature reading notes, and interaction notes to show how the participant walked out of the teaching-research contradiction and finally achieved professional development. The findings indicate that the college English teacher’s perception of the research-teaching nexus developed when she actively exercised her agency to take part in social interactions in a supportive sociocultural environment with the regulation of appropriate mediational tools. The conceptual progress in the research-teaching nexus finally contributed to her professional development in both teaching and research. The findings of this study have implications for non-key universities and their academics on how to effectively promote teaching-research integration.
Gene expression signature of human neuropathic pain identified through transcriptome analysis

Introduction: Neuropathic pain is a type of chronic pain that is characterized by ongoing discomfort and can be challenging to manage effectively. This study aimed to identify genes associated with neuropathic pain through transcriptome analysis in order to gain a better understanding of the mechanisms underlying this chronic, difficult-to-treat pain. Methods: We conducted transcriptome analysis using a training datasetof 202 individuals, including patients with neuropathic pain and healthy controls. Results: Our analysis identified five genes (GTF2H2, KLHL5, LRRC37A4P, PRR24, and MRPL23) that were significantly differentially expressed in the tissue of patients with neuropathic pain compared to controls. We constructed a neuropathic pain signature using these five genes and validated it using an independent dataset of 25 individuals. Receiver operating characteristic (ROC) curve analysis demonstrated that this signature had a high level of accuracy in differentiating between neuropathic pain patients and healthy controls, with an area under the curve (AUC) of 0.83 (95% CI 0.65–1). Discussion: These findings suggest that these five genes may be potential therapeutic targets for neuropathic pain.
Termination Proofs for Logic Programs Based on Predicate Inequalities

A clip attached to the ends of a power driven rotary brush to insure proper mounting of the brush within a vacuum cleaner nozzle. Axle pins extend outwardly from the brush ends and are rotatably journaled, eccentrically in stationary bearing blocks. A squared end member is fixed on each block and is held in an inverted U-shaped spring bracket mounted on the nozzle, releaseably mounting the brush within the nozzle. The attachment or mounting clip is formed with a squared opening through which the brush end member is inserted for mounting the clip thereon. Flanges are formed on three sides of the clip forming an open clip end through which the bracket passes when mounting the brush within the nozzle. The open end of the clip thus enables the brush ends to be inserted in only one preset eccentric position in the bracket, insuring the same degree of eccentricity at both ends of the brush.
The effect of prestimulus low-frequency neural oscillations on the temporal perception of audiovisual speech

Objective Perceptual integration and segregation are modulated by the phase of ongoing neural oscillation whose frequency period is broader than the size of the temporal binding window (TBW). Studies have shown that the abstract beep-flash stimuli with about 100 ms TBW were modulated by the alpha band phase. Therefore, we hypothesize that the temporal perception of speech with about hundreds of milliseconds of TBW might be affected by the delta-theta phase. Methods Thus, we conducted a speech-stimuli-based audiovisual simultaneity judgment (SJ) experiment. Twenty human participants (12 females) attended this study, recording 62 channels of EEG. Results Behavioral results showed that the visual leading TBWs are broader than the auditory leading ones [273.37 ± 24.24 ms vs. 198.05 ± 19.28 ms, (mean ± sem)]. We used Phase Opposition Sum (POS) to quantify the differences in mean phase angles and phase concentrations between synchronous and asynchronous responses. The POS results indicated that the delta-theta phase was significantly different between synchronous and asynchronous responses in the A50V condition (50% synchronous responses in auditory leading SOA). However, in the V50A condition (50% synchronous responses in visual leading SOA), we only found the delta band effect. In the two conditions, we did not find a consistency of phases over subjects for both perceptual responses by the post hoc Rayleigh test (all ps > 0.05). The Rayleigh test results suggested that the phase might not reflect the neuronal excitability which assumed that the phases within a perceptual response across subjects concentrated on the same angle but were not uniformly distributed. But V-test showed the phase difference between synchronous and asynchronous responses across subjects had a significant phase opposition (all ps < 0.05) which is compatible with the POS result. Conclusion These results indicate that the speech temporal perception depends on the alignment of stimulus onset with an optimal phase of the neural oscillation whose frequency period might be broader than the size of TBW. The role of the oscillatory phase might be encoding the temporal information which varies across subjects rather than neuronal excitability. Given the enriched temporal structures of spoken language stimuli, the conclusion that phase encodes temporal information is plausible and valuable for future research.
Language switching and domain-general control in interpreters

The purpose of this paper is to examine whether and how training and professional experience in interpreting affect task switching in this bilingual population. In the first experiment, we compared a group of interpreting students to a group of translation students using the bilingual categorization task to assess their domain-specific language switching before and after training. In the second experiment, we added a group of professional interpreters to the participants in experiment 1 to test prepotent response inhibition using the Simon task (domain-general). First, the results showed training-related improvement in the bilingual categorization task in both student groups, indicating a similar effect for translation and interpreting training. Second, both student groups showed better performance on the Simon task compared to professional interpreters, but only on response times and not on accuracy. The correlation analyses of the two tasks in student groups only showed significant correlations between the global RTs and supported the hypothesis that proactive language control may depend more on inhibition than on the switching-specific factor. Considering language background, the lower onset age of L2 acquisition (AOA2) in the interpreting students (compared to the translation students) was significantly correlated with the congruency effect in the Simon task, indicating an impact of language background on domain-general control. Results were discussed in light of the different engaging elements, including task specificity, training length, research method, and participants' linguistic profile.
Seasonal succession of microbial community co-occurrence patterns and community assembly mechanism in coal mining subsidence lakes

Coal mining subsidence lakes are classic hydrologic characteristics created by underground coal mining and represent severe anthropogenic disturbances and environmental challenges. However, the assembly mechanisms and diversity of microbial communities shaped by such environments are poorly understood yet. In this study, we explored aquatic bacterial community diversity and ecological assembly processes in subsidence lakes during winter and summer using 16S rRNA gene sequencing. We observed that clear bacterial community structure was driven by seasonality more than by habitat, and the α-diversity and functional diversity of the bacterial community in summer were significantly higher than in winter (p < 0.001). Canonical correspondence analysis indicated that temperature and chlorophyll-a were the most crucial contributing factors influencing the community season variations in subsidence lakes. Specifically, temperature and chlorophyll-a explained 18.26 and 14.69% of the community season variation, respectively. The bacterial community variation was driven by deterministic processes in winter but dominated by stochastic processes in summer. Compared to winter, the network of bacterial communities in summer exhibited a higher average degree, modularity, and keystone taxa (hubs and connectors in a network), thereby forming a highly complex and stable community structure. These results illustrate the clear season heterogeneity of bacterial communities in subsidence lakes and provide new insights into revealing the effects of seasonal succession on microbial assembly processes in coal mining subsidence lake ecosystems.
Network pharmacology and experimental validation to explore the potential mechanism of Sanjie Zhentong Capsule in endometriosis treatment

Purpose Sanjie Zhentong Capsule (SZC) is gradually becoming widely used in the treatment of endometriosis (EMs) and has demonstrated an excellent curative effect in the clinic. However, the active components and mechanisms of Sanjie Zhentong Capsule (SZC) in the treatment of endometriosis (EMs) remain unclear, and further research is needed to explore the effects of Sanjie Zhentong Capsule (SZC). Materials and methods First, a drug target database of Sanjie Zhentong capsule (SZC) was established by consulting the TCMSP database and related literature. An endometriosis (EMs) disease target database was then established by consulting the GeneCards, OMIM and Drug Bank databases. The overlapping genes of SZC and EMs were determined, and protein-protein interactions (PPIs), gene ontology (GO) and Kyoto Gene and Genome Encyclopedia (KEGG) analyses were performed to predict the potential therapeutic mechanisms. Molecular docking was used to observe whether the key active ingredients and targets predicted by network pharmacology had good binding energy. Finally, in vitro experiments such as CCK-8, flow cytometry and RT-PCR assays were carried out to preliminarily verify the potential mechanisms. Results Through the construction of a pharmacological network, we identified a total of 28 active components in SZC and 52 potential therapeutic targets. According to GO and KEGG enrichment analyses, the effects of SZC treatment may be related to oxidative stress, steroid metabolism, apoptosis and proliferation. We also experimentally confirmed that SZC can regulate the expression of steroid hormone biosynthesis-related genes, inhibit ectopic endometrial stromal cell (EESC) proliferation and oxidative stress, and promote apoptosis. Conclusion This study explored the potential mechanism of SZC in the treatment of EMs through network pharmacology and experiments, providing a basis for further future research on SZC in the treatment of EMs.
Rare copy number variation analysis identifies disease-related variants in atrioventricular septal defect patients

Atrioventricular septal defect (AVSD) is a deleterious subtype of congenital heart diseases (CHD) characterized by atrioventricular canal defect. The pathogenic genetic changes of AVSD remain elusive, particularly for copy number variation (CNV), a large segment variation of the genome, which is one of the major forms of genetic variants resulting in congenital heart diseases. In the present study, we recruited 150 AVSD cases and 100 healthy subjects as controls for whole exome sequencing (WES). We identified total 4255 rare CNVs using exon Hidden Markov model (XHMM) and screened rare CNVs by eliminating common CNVs based on controls and Database of Genomic Variants (DGV). Each patient contained at least 9 CNVs, and the CNV burden was prominently presented in chromosomes 19,22,21&16. Small CNVs (<500 kb) were frequently observed. By leveraging gene-based burden test, we further identified 20 candidate AVSD-risk genes. Among them, DYRK1A, OBSCN and TTN were presented in the core disease network of CHD and highly and dynamically expressed in the heart during the development, which indicated they possessed the high potency to be AVSD-susceptible genes. These findings not only provided a roadmap for finally unveiling the genetic cause of AVSD, but also provided more resources and proofs for clinical genetics.
Design of anti-load perturbation flight trajectory stability controller for agricultural UAV

The unmanned aerial vehicle(UAV) used in agricultural fields usually has a load, which affects stability of flight trajectory. This problem is a great technical challenge and critical issue which has fascinated many researchers in this area. This research paper presents a flight dynamics model for agricultural UAV under load condition. The robust T-S fuzzy control method is applied in the attitude angle control part, and the traditional PID controller is used in the position loop control part. Results of simulation depict that the flight trajectory of agricultural UAV can reach certain stability when the load is relatively small.
Diazotrophy of rhizobia associated with rice plants cv. INCA LP-5 and INCA LP-7

The rhizobia have been studied, fundamentally, for their capacity to carry out the biological nitrogen fixation, an attribute that at present has also been verified in its interaction with non-legume plants. The aim of this research was to evaluate the capacity to fix nitrogen of rhizobia strains, from the rhizosphere rice plants cultivars INCA LP-5 and INCA LP-7, cultivated in intensive monoculture. The research was carried out in 2018, at the National Institute of Agricultural Sciences from Cuba and at the Center for Genomic Sciences in Mexico. The diazotrophy of three Rhizobium strains was determined by three methods. The amplification of nif H gene, for which three sets of primers and different alignment times and temperatures were used in the PCR technique; through the growth of strains in two semi-solid nitrogen-free media and through inoculation tests with siratro and soy plants, under controlled conditions. The nif H gene was not amplified from any of three rhizobia strains; however, they grew in nitrogen-free media and formed effective nodules on siratro and soy roots. The strain Rhizobium sp. Rpr11 produced the highest number of nodules in both legumes roots, 30 days after inoculation. This research is a first approach to understand the capacity to nitrogen fixation of rhizobia strains associated with Cuban rice cultivars under intensive monoculture.