Miracle-dz/UniFAR-FTUs huggingface dataset:
Genomic Imbalances in the Placenta Contribute to Poor Fetal Growth

Background: Fetal growth restriction (FGR) is associated with increased risks for complications before, during, and after birth, in addition to risk of disease through to adulthood. Although placental insufficiency, failure to supply the fetus with adequate nutrients, underlies most cases of FGR, its causes are diverse and not fully understood. One of the few diagnosable causes of placental insufficiency in ongoing pregnancies is the presence of large chromosomal imbalances such as trisomy confined to the placenta; however, the impact of smaller copy number variants (CNVs) has not yet been adequately addressed. In this study, we comprehensively evaluate the contribution of both placental aneuploidy and CNVs to fetal growth. Methods: We used molecular-cytogenetic approaches to identify aneuploidy in placentas from N=101 infants born small-for-gestational age (SGA), typically used as a surrogate for FGR, and from N=173 non-SGA controls from uncomplicated pregnancies. We confirmed aneuploidies and assessed mosaicism by microsatellite genotyping. We then profiled CNVs using high-resolution microarrays in a subset of N=53 SGA and N=61 control euploid placentas, and compared the load, impact, gene enrichment and clinical relevance of CNVs between groups. Candidate CNVs were confirmed using quantitative PCR.Results: Aneuploidy was over 10-fold more frequent in SGA-associated placentas compared to controls (11.9% vs. 1.1%; p=0.0002, OR=11.4), was confined to the placenta, and typically involved autosomes, whereas only sex chromosome abnormalities were observed in controls. We found no significant difference in CNV load or number of placental-expressed or imprinted genes in CNVs between SGA and controls, however, a rare and likely clinically-relevant germline CNV was identified in 5.7% of SGA cases. These CNVs involved candidate genes INHBB, HSD11B2, CTCF, and CSMD3. Conclusions: We conclude that placental genomic imbalances at the cytogenetic and submicroscopic level may underlie up to ~18% of SGA cases in our population. This work contributes to the understanding of the underlying causes of placental insufficiency and FGR, which is important for counselling and prediction of long term outcomes for affected cases.
THE PERCEIVED CULTURAL BARRIERS TO EFFECTIVE COMMUNICATION TOWARDS PATIENT AMONG NON-SAUDI REGISTERED NURSES OF A PUBLIC HOSPITAL, THE KINGDOM OF SAUDI ARABIA

Background: In the Kingdom of Saudi Arabia (KSA) health care setting effective communication is a central to the provision of compassionate and high-quality nursing care. The aim of the survey is to study the perceived cultural barriers to effective communication towards patient and knowledge towards culture working environment among non-Saudi registered nurses in a hospital in KSA. Methodology: This is cross-sectional survey conducted from January 2017 to Jun 2018 thorough self-administration questionnaire. The questionnaire was distributed to 150 nurses that randomly selected from medical and surgical fields and received feedback with total number 135 nurses. Results: Most of the respondents were female 125 (92.6%) between 26 to 30 years. In terms of years of experience, 49 (36.3%) had five to ten years of experience, and the rest 89 (65.9%) had no previous working experience in Saudi. The findings displayed that physical and mental tiredness for 55 (40.7%). The second ranked respondents strongly agreed that cultural communication barriers come from hard nursing tasks 45 (33.3%), heavy nursing workload 46 (34.1%) and followed by lack of information and skills in communication for which 50 (37.0%). Conclusion: The respondents considering communication barriers are related to personal and social characteristics, job specification, clinical situation of patients and environmental factors. There are significant results regarding the knowledge towards culture working environment in terms of nurses' perception, cultural norms and culture on life activities.
Seroprevalence of Cytomegolovirus Infection among Aborted Women in Thi-Qar Governorate

Venous blood had been collected from sexity women with habitual abortion from Thi-Qar Governorate cities to study and evaluate the prevalence of Cytomegalovirus infection and from twenty healthy looking women as control. The test performed using ELISA method to detect the IgM and IgG antibodies in patients and control sample by commercial kit. The result showed that 60 of 60 women (100%) had antibodies against CMV, 9 (15%) with IgM antibodies, 21 (35%) with IgG antibodies and 30 (50%) with both IgM and IgG antibodies. Other women (controls)
PENGARUH KOMPETENSI EMOSIONAL DAN PENGENDALIAN PEKERJAAN TERHADAP KINERJA KARYAWAN PD BPR BANK BULELENG 45 SINGARAJA

Pengaruh Kompetensi Emosional dan Pengendalian Pekerjaan terhadap Kinerja Karyawan PD BPR Bank Buleleng 45 Singaraja. Tujuan dari penelitian ini adalah untuk memperoleh temuan eksplanasi yang teruji tentang pengaruh kompetensi emosional dan pengendalian pekerjaan terhadap kinerja baik secara simultan maupun parsial pada karyawan PD BPR Bank Buleleng 45 Singaraja. Penelitian ini dilakukan terhadap 58 karyawan dengan menggunakan desain penelitian kuantitatif. Data dikumpulkan dengan teknik kuesioner dan dianalisis dengan analisis regresi ganda. Temuan hasil penelitian menunjukkan bahwa kompetensi emosional dan pengendalian pekerjaan baik secara simultan maupun parsial berpengaruh positif dan signifikan terhadap kinerja karyawan pada PD BPR Bank Buleleng 45 Singaraja. Kata Kunci : kinerja karyawan, kompetensi emosional, pengendalian pekerjaan The influence of Emotional Competency and Job Control on the Employee’s Performnce in the PD BPR Bank Buleleng 45 Singaraja. The purpose of this research is obtaining explanation finding which was been examined about the influence emotional competency and job control both simultaneously and partial in employee’s performance in the PD BPR Bank Buleleng 45 Singaraja. Data was collected by questionnaire and analyzed by multiple regression analysis. This research had been done in 58 employees by using kuantitative research design. The results of research show that emotional competency and job control both simultaneously and partial had been influenced positive and significant on the emplioyee’s performance in the PD BPR Bank Buleleng 45 Singaraja. keyword : employee’s performance, emotional competency, job control
MODELLING OF ARTIFICIAL NEURAL NETWORK CONTROLLER FOR ELECTRIC DRIVE WITH LINEAR TORQUE LOAD FUNCTION

The purpose of this research is to model usage of neural network for speed control of DC drive in virtual laboratory. The paper is based on authors' previous scientific work researching the intelligent electronic devices for public electric transport, which use methods of the artificial intelligence and may communicate in global network with other intelligent devices. In this paper authors presents modeling of neural network controller to control speed of DC drive. DC drives are widely used in public electric transport, such as trams, trolleybuses and electric trains. The feed-forward backpropagation neural network is used for controller. Levenberg-Marquardt backpropagation algorithm is proposed as a training method. Neural network is trained to maintain speed of DC drive in defined interval. Results of modelling show the possibility to use neural network controller for speed control of DC drive.
Cleanroom Microbiology for the Non-Microbiologist

THE SCOPE OF MICROBIOLOGY Introduction Cells Binomial Nomenclature Morphology New! Specific Microbial Groups New! Taxonomy of Microorganisms Microscopy Summary References GROWTH OF MICROORGANISMS Introduction Growth of Bacteria New! Growing Other Microorganisms: Fungi, Protozoa, Algae and Viruses Aseptic Technique New! Safety Issues Summary References CONTROLLING GROWTH AND ACTIVITIES OF MICROORGANISMS Introduction New! Definitions Physical Methods of Control New! Assuring Sterility New! Chemical Methods of Control Control of Microorganisms in High Purity Water Systems Summary References FACILITIES AND PERSONNEL CONTROLS Introduction New! Certified Cleanrooms New! Bioclean Facilities- Viable vs. Non-Viable Particles Clean Facilities - General Considerations New! Unidirectional Air Flow New! HEPA and ULPA Filters New! Aseptic Fill Areas New! Barriers, Clean Zones and Isolators New! Biosafety Levels Cleanroom Garments New! Personnel Practices and Training New! Personal Hygiene General Personnel Practices Summary References DETECTION AND ENUMERATION OF MICROORGANISMS IN THE CLEANROOM Introduction New! Overview of Microbiological Environmental Monitoring New! Monitoring of Air Fallout Methods Surface Monitoring New! Touch Plates and Other Personnel Monitoring Microbiological Assessment of Liquids Microbiological Assessment of Solids and Semisolids New! Monitoring for Specific Microorganisms New! Rapid Methods of Identification New! Testing for Bacteriostasis and Fungistasis New! Detection of Biofilms Sterile Media Fill Tests Alert and Action Levels New! The Sterility Suite Disposal of Cultures Summary References
An improved HIV care cascade to assess HIV control programs among people who inject drugs.

Background Achievement of HIV control among key populations through universal access to antiretroviral treatment (ART) requires a precise evaluation of the cascade of care. One of the main difficulties in obtaining an accurate community-based cascade of care is misreporting, which could represent one of the most important bias for people suffering from stigma. The primary objective was to estimate the added value of plasma antiretroviral concentration to improve the estimation of HIV cascade of careMethods We constructed the cascade of HIV care among persons who inject drugs (PWID) living in Hai Phong, Vietnam, using a community-based survey. First and second line HIV treatment contained fixed dose of lamivudine. Misreporting of HIV status and ART were identified by plasma lamivudine detection. We then compared the two methods for estimating the cascade of HIV careResults The proportion of misreporting was estimated at 30% among PWID. No specific PWID profile could be identified as associated with misreporting.Conclusions Adding plasma ARV detection to the routine data collection strongly improved the accuracy of the HIV cascade of care.
Electrostatic modification of the bending stiffness of adaptive structures

Adaptive structures are characterized by their ability to reversibly modify their response to external mechanical stimuli so as to extend their operational space (i.e. the range of conditions under which they can operate). This feature differentiates adaptive structures from conventional ones, that are designed to maintain their properties invariant over time. Typically, adaptive structures are comprised of a host structure, one or more actuators, sensors to determine the actual state or trajectory of the structure and a control system. The bulk of the research done in this field focuses on the development of new transducing materials and systems to be used in material based actuators. The present work focuses on the development of host structures with variable mechanical properties. The ability to modify the bending stiffness or the damping properties of a structure can be used to increase the functionality of the actuators in active structures or to suppress high amplitude vibrations in passive ones. The suppression of vibrations can be achieved either by shifting the eigenfrequency of the structure, thus avoiding resonance in the case of narrow band excitation (energy rejection) or by introducing a higher level of damping (energy dissipation). The original contribution made by this work lies in the development and description of a structure that has the ability to adaptively modify its behavior based on a change in mechanical properties, rather than thanks to the action of one or more actuators. The change of the structure’s properties is caused by an apparent change of its topology. Very limited literature on the use of electrostatic forces to modify the interaction between the layers of a multi-layer structure and thus its bending stiffness is available. This moderate level of knowledge on the working mechanism of multi-layer structures with variable bending stiffness, warrants the global approach to the discussion of this topic taken in this dissertation. After giving an overview on the current state of the art in variable stiffness structures, this work first describes the working principle at the base of the modification of the mechanical properties of simple structures, then it proceeds to confirming the validity of the description with the help of simple models and experi-
The changes of posterior corneal curvature, topographic corneal thickness and corneal biomechanical properties from overnight orthokeratology lens wear and recoveries of these parameters

This thesis is protected by copyright, with all rights reserved. By reading and using the thesis, the reader understands and agrees to the following terms: 1. The reader will abide by the rules and legal ordinances governing copyright regarding the use of the thesis. 2. The reader will use the thesis for the purpose of research or private study only and not for distribution or further reproduction or any other purpose. 3. The reader agrees to indemnify and hold the University harmless from and against any loss, damage, cost, liability or expenses arising from copyright infringement or unauthorized usage.
How Software Startups Survive: a Model based on Resource-based View and Dynamic Capabilities

Rapid advances of IT have encouraged many software startups to enter the market place. Our research seeks to investigate the little-studied phenomenon of software startup survival. The research is based on the resource-based view and on dynamic capabilities. We present a research model that investigates factors affecting software startup survival by examining how startups survive in their competitive environment. First, we categorize the resources of software startups into three areas based on socio-technical theory. Specifically, we view entrepreneurial resources as influencing both IT innovation and environmental resources. Second, we view dynamic capabilities as mediating the relationship between interactions among resources and software startup survival. Finally, we investigate the effect of competitive actions in moderating the relationship between dynamic capabilities and software startup survival. Our research seeks to contribute to extant research by proposing the first empirical study of which we are aware that addresses factors influencing software startup survival.
Performance Analysis of Sparse Matrix Representation in Hierarchical Temporal Memory for Sequence Modeling

Hierarchical Temporal Memory (HTM) is a special type of artificial neural network (ANN), that differs from the widely used approaches. It is suited to efficiently model sequential data (including time series). The network implements a variable order sequence memory, it is trained by Hebbian learning and all of the network’s activations are binary and sparse. The network consists of four separable units. First, the encoder layer translates the numerical input into sparse binary vectors. The Spatial Pooler performs normalization and models the spatial features of the encoded input. The Temporal Memory is responsible for learning the Spatial Pooler’s normalized output sequence. Finally, the decoder takes the Temporal Memory’s outputs and translates it to the target. The connections in the network are also sparse, which requires prudent design and implementation. In this paper a sparse matrix implementation is elaborated, it is compared to the dense implementation. Furthermore, the HTM’s performance is evaluated in terms of accuracy, speed and memory complexity and compared to the deep neural network-based LSTM (Long Short-Term Memory).
The perception of simultaneous pitches in ambiguous sounds

This study explored the perception of simultaneous pitches among sounds of varying pitch strength. Eighteen musicians performed estimations of pitch number and pitch height for stimuli with increasing inharmonicity and spectral density. Sounds consisted of either one, two or three simultaneous pitches. Stimulus properties were shown to affect performance differently according to the task undertaken. These results suggest that pitch number and height information may be extracted by independent cognitive mechanisms.
The Response of Second Line Chemotherapy Platinum Resistant Ovarian Cancer in Sudan: 2013-2017

Background Ovarian carcinoma is the fifth leading cause of cancer death worldwide. The tumor mostly associated with variant factors such as advance age, early menstruation and gene association. We aimed to highlight the effectiveness of the second line chemotherapy in the management of ovarian cancer patients in Sudan.Methods The data were collected from the hospital patient’s records for five years period of time, included 62 patients with ovarian cancer who is treated by the second line platinum resistant chemotherapy.Result The peak prevalence of the patients was found in Al-Gazeera state, and the least in Al-Gadarif state. Age group above 55 years was the most affected group. The vast majority of patients showed partially mass disappearing, completes and continue growing tumor respectively. All patients received variant cycles of chemotherapy as fellow 3, 6, 2, 4, 5, 1 cycle respectively. 79.4% of the patients had achieved the normal value of cancer antigen 125 (CA125) levels after the treatment. In 50% of patients the cancer recurred after 1-2 months, 32.2% after 3-4 months and 17.8% after 5-6 months. The serous adenocarcinoma was found to be the most histological type in all the patients and the least two types were observed are cell carcinoma and serous papillary.Conclusion Our findings suggested that, Al-Gazeera state citizens were more vulnerable to resist the first line chemotherapy than others. The Sudanese patients with ovarian cancer may have better response to Gemzar.
Una propuesta para la arquitectura informática del sistema de control de un edificio

Nowadays, in order to perform the optimal installations automatic control, buildings structure incorporates a new kind of computers which are different from the desk computers dedicated to user’s personal tasks. These computers spread in the form of a network that is overlapped with the building structure in such a way that soon we shall speak about the computer omnipresence in the building. The building control system is considered in this paper as an intelligent agent. This means a control system provided with sensors and actuators to interact with its environment. This control system must develop its activity in order to get autonomously the programmed goals. A generic control building architecture is presented as a step towards the systematic development of control building systems. A project for the development of a software tool is also presented. This tool intends to support and make easy the programming of such kind of control systems. This project is been developed in the Department of Photonic Technology at Universidad Politecnica of Madrid.
Food Safety Implications of Biofilms Formed by Resident Bacteria in Fresh-cut Processing Environments

Title of Document: FOOD SAFETY IMPLICATIONS OF BIOFILMS FORMED BY RESIDENT BACTERIA IN FRESH-CUT PROCESSING ENVIRONMENTS Tong Liu, Doctor of Philosophy, 2013 Directed By: Y. Martin Lo, Ph.D., Department of Nutrition and Food Science Biofilms on equipment surfaces can be vectors for cross-contaminations in food processing facilities. A particular problem is that biofilms can protect pathogenic bacteria from daily cleaning and disinfection operations. In the present study, microflora were recovered from fresh-cut processing facilities, identified, and tested for biofilm forming potential. Subsequently, dual-species biofilms of selected isolates and Escherichia coli O157:H7 were investigated. Approximately 30% of the isolates were potent biofilm formers, producing large amounts of biomass. A hundred and seventeen tested isolates were identified into 23 genera, including plant related bacteria and coliforms with some opportunistic pathogens. Dual-species biofilms formed by Burkholderia caryophylli or Ralstonia insidiosa and E. coli O157:H7 manifested increased biomass in comparison to their monocultures. Additionally, about a one-log unit increase of E. coli O157:H7 cell counts were observed for both dual-species biofilms. To test the effects of environmental factors on growth of R. insidiosa and E. coli O157:H7 in dual-species biofilms, factors tested included low temperature (10 C), media with different composition of nutrient sources (10% TSB, M9, 1.25% Cantaloupe Juice) and a continuous culture system with limited nutrients. E. coli O157:H7 cell counts increased for all tested conditions. To examine bacterial localization within biofilms, confocal laser scanning microscopy (CLSM) and transmission electron microscopy (TEM) were used. Images showed distinct spatial distributions with E. coli O157:H7 commonly located at the bottom and also interspersed among R. insidiosa cells. To test the interactions with other pathogens, R. insidiosa was co-cultured with Listeria monocytogenes, Salmonella spp. , and Shiga toxin-producing E. coli. Cells counts for 7 out of 9 tested pathogenic bacteria strains were increased (0.36-1.60 CFU log units). It is notable that the biomass formed by R. insidiosa and L. monocytogenes was much greater than those produced by other tested combinations. These results indicate that R. insidiosa could be a food safety risk in freshcut processing environments by providing protective habitats for pathogenic bacteria. FOOD SAFETY IMPLICATIONS OF BIOFILMS FORMED BY RESIDENT BACTERIA IN FRESH-CUT PROCESSING ENVIRONMENTS
Composing by Pen: Exploring the effectiveness of a system for writing music notation on computers via pen input

For centuries pens have been used to write music notation on paper. Music notation in computer systems is usually entered by computer transcription of MIDI performance, or mouse selection and placement from pallets of note symbols. This paper presents the findings from an empirical exploration of a system for music notation on computer using pen input with simplified gestures. The results indicate that whilst there appear to be many benefits to such an approach, particularly the flexible placement and actuate editing of symbols, the implementation employed is considered overly error prone and suffering from inadequate hardware support, in the form of on-screen drawing with the pen, to be compelling. In addition, the absence of audible feedback and performance capture were considered significant disadvantages by the users. Despite these shortcomings, mostly not direct pen concerns, the results forecast that for music notation entry, pen input may be preferable to mouse input and that gesture recognition may be quicker than the pallet-selection techniques most often employed in current music systems. In short, the potential of pen input is not devoid of context.