Miracle-dz/UniFAR-FTUs huggingface dataset:
Unraveling the Role of Epithelial–Mesenchymal Transition in Adenoid Cystic Carcinoma of the Salivary Glands: A Comprehensive Review

Simple Summary Salivary adenoid cystic carcinoma (SACC) is an aggressive tumor that exhibits a neurotropic growth pattern by invading nerve fibers and demonstrates a high tendency for both local spread and early distant metastases. The limited availability of successful chemotherapeutic regimens represents a major obstacle in the efficient treatment of SACC patients. Through epithelial–mesenchymal transition (EMT), cancer cells gain increased mobility and invasiveness, facilitating their ability to infiltrate the basement membrane and disseminate to distant sites in the body. This manuscript aims to review the latest research on potential biomarkers that contribute to the development of EMT, which can aid in identifying new therapeutic targets and improving the oncological management of SACC patients. Abstract Salivary adenoid cystic carcinoma (SACC) is considered a challenging malignancy; it is characterized by a slow-growing nature, yet a high risk of recurrence and distant metastasis, presenting significant hurdles in its treatment and management. At present, there are no approved targeted agents available for the management of SACC and systemic chemotherapy protocols that have demonstrated efficacy remain to be elucidated. Epithelial–mesenchymal transition (EMT) is a complex process that is closely associated with tumor progression and metastasis, enabling epithelial cells to acquire mesenchymal properties, including increased mobility and invasiveness. Several molecular signaling pathways have been implicated in the regulation of EMT in SACC, and understanding these mechanisms is crucial to identifying new therapeutic targets and developing more effective treatment approaches. This manuscript aims to provide a comprehensive overview of the latest research on the role of EMT in SACC, including the molecular pathways and biomarkers involved in EMT regulation. By highlighting the most recent findings, this review offers insights into potential new therapeutic strategies that could improve the management of SACC patients, especially those with recurrent or metastatic disease.
Tri-level Thresholding using Invasive Weed Optimization based on Nonextensive Fuzzy Entropy

This study presents a tri-level thresholding method for image segmentation with invasive weed optimization (IWO) algorithm. The objective of the proposed approach is to handle the nonextensivity and vagueness of image in segmentation, in the meanwhile to reduce the computation time. In this study, the histogram of image is converted to fuzzy domain by membership function firstly. Then the thresholding method is constructed through maximizing the sum of nonextensive entropy of subsets of the each part of fuzzy histogram. The IWO algorithm is used to search the optimal thresholds to reduce the computation time in the new method. Experiments on synthetic and real-world images are given to demonstrate the effectiveness of the proposed approach compared with the other methods.
Utility of narrow-band imaging with or without dual focus magnification in neoplastic prediction of small colorectal polyps: a Vietnamese experience

Background/Aims Accurate neoplastic prediction can significantly decrease costs associated with pathology and unnecessary colorectal polypectomies. Narrow-band imaging (NBI) and dual-focus (DF) mode are promising emerging optical technologies for recognizing neoplastic features of colorectal polyps digitally. This study aimed to clarify the clinical usefulness of NBI with and without DF assistance in the neoplastic prediction of small colorectal polyps (<10 mm). Methods This cross-sectional study included 530 small colorectal polyps from 343 consecutive patients who underwent colonoscopy at the University Medical Center from September 2020 to May 2021. Each polyp was endoscopically diagnosed in three successive steps using white-light endoscopy (WLE), NBI, and NBI-DF and retrieved for histopathological assessment. The diagnostic accuracy of each modality was evaluated with reference to histopathology. Results There were 295 neoplastic polyps and 235 non-neoplastic polyps. The overall accuracies of WLE, WLE+NBI, and WLE+NBI+NBI-DF in the neoplastic prediction of colorectal polyps were 70.8%, 87.4%, and 90.8%, respectively (p<0.001). The accuracy of WLE+NBI+NBI-DF was signiﬁcantly higher than that of WLE+NBI in the polyp size ≤5 mm subgroup (87.3% vs. 90.1%, p<0.001). Conclusions NBI improved the real-time neoplastic prediction of small colorectal polyps. The DF mode was especially useful in polyps ≤5 mm in size.
Computing solution concepts in games with integer decisions

Computing solution concepts in games is an important endeavor in the field of algorithmic game theory. This thesis explores two contexts – simultaneous games and sequential games – for computing solution concepts in games where some or all of the decisions of players can be modeled as integer vectors. In the case of simultaneous games, the problem of computing pure strategy in Nash equilibrium (pure NE) is considered in two classes of compactly represented games ; that is, games where the set of players, actions or utilities are expressed compactly by an input smaller than the standard normal form representation. The first class considered is integer programming games where actions are sets of integer points and utilities have a special difference of piecewise linear convex structure. The second class considered is symmetric games with general piecewise linear utilities. Both classes can be highly expressive of general normal form games, but can also be highly compact. The main results are polynomial-time algorithms for counting and finding pure NE when certain parameters are fixed and where the input is a description of the piecewise linear utilities. In both cases this can yield improved efficiency over known algorithms. In the case of sequential games, the problem of finding optimal “optimistic solutions” to bilevel integer programs are explored. In particular by using recent results from parametric integer programming, a polynomial-time (in fixed dimension) algorithm is derived. Existence results for optima in a more general setting involving a multilinear lower level objective representing leader-controlled units costs are also stated using a decomposition of the original
EFFECT OF DIFFERENT IRRIGATION REGIMENS ON EFFECT OF DIFFERENT IRRIGATION REGIMENS ON ENTEROCOCCUS FAECALIS ELIMINATION FROM INFECTED ROOT ENTEROCOCCUS FAECALIS ELIMINATION FROM INFECTED ROOT CANALS (AN IN-VITRO COMPARATIVE STUDY) CANALS (AN IN-VITRO COMPARATIVE STUDY)

Abstract Microorganisms harbored in the complexities of root canal systems might lead to endodontic failures and development of apical periodontitis. Enterococcus faecalis is the most common isolated bacteria in these cases. Aim: This study was conducted to compare the efficiency of four irrigation regimens on the elimination of an inoculated strain of E. faecalis. Materials and Methods: Forty single rooted extracted premolars were inoculated with a standard strain of Enterococcus faecalis (ATCC 29212) and incubated at 37˚C for two weeks to allow infection of the dentinal tubules. The bacterial suspension was replaced with a new one every 48 hours. The teeth were then divided into four groups of n=10 each, to apply irrigation regimens as follows: Group i: irrigation with normal saline, Group ii: syringe irrigation (NaOCl 2.625%), Group iii: NaOCl 2.625%+EndoActivator and Group iv: NaOCl 2.625%+diode laser. Samples were collected at baseline and after irrigation. Colony-forming unit counts were performed. For baseline count of E. faecalis, differences in means between the groups were tested using the one way ANOVA F test. For the count of E. faecalis after the irrigation, differences in means was assessed using the Kruskal Wallis test. Results: The mean values of % of E. faecalis killed were respectively 99.2 ± 2.53% in group iv, 98.3± 5.34% in group iii, 29.0 ± 5.46% in group ii and 4.77 ± 0.78%) in group i. Conclusion: Maximum removal of E. faecalis strains was achieved by activating 2.625% sodium hypochlorite with the diode laser.
Each Copy of the Real Line in is Removable

Abstract Around 1995, Professors Lupacciolu, Chirka and Stout showed that a closed subset of ${{\mathbb{C}}^{N}}\left( N\ge 2 \right)$ is removable for holomorphic functions, if its topological dimension is less than or equal to $N\,-\,2$ . Besides, they asked whether closed subsets of ${{\mathbb{C}}^{2}}$ homeomorphic to the real line (the simplest 1-dimensional sets) are removable for holomorphic functions. In this paper we propose a positive answer to that question.
A Multistage Variational Iteration Method for Solution of Delay Differential Equations

Abstract In this paper, the approximate solution of delay differential equations is obtained by a reliable algorithm based on an adaptation of the classical variational iteration method (VIM), which is called the multi-stage variational iteration method (MSVIM). Examples are carried out and numerical results with comparison to exact solutions, VIM and MATLAB dde23 solver are given. The comparison reveals that the MSVIM is a promising tool to solve delay differential equations.
Social Communication in Conceptual Works of Contemporary Ceramics

Contemporary ceramic art and intellectual trends, where the ceramic form became interactive from society and mixed with the environment, and in conceptual art, the concept or meaning behind his work is more than his aesthetic function, this study forms four chapters. Its first chapter is concerned with the problem related to the research, its importance and limitations, and it defines the terms used. As for its second chapter, it is related to the framework of theoretical research and previous studies, and the concept of social communication is dealt with in its first axis, while its second axis deals with postmodern ceramics. In the third chapter, the procedures that were taken to implement the research are explained, where the research category of (15) potters was formed, the study sample and the tools used, the descriptive analytical approach was determined, and an analysis was conducted on a sample of the research consisting of (3) ceramic samples. As for its fourth chapter, it includes a review of the results, recommendations and conclusions.
The Influence of African Easterly Waves on Convection over Tropical Africa and the East Atlantic

AbstractUsing data from the Tropical Rainfall Measuring Mission (TRMM), the modulation of convection by African easterly waves (AEWs) is investigated over regions of the east Atlantic and tropical Africa. To explain the modulation of convection, the large-scale environment (lift, moisture, conditional instability, and shear) is also examined as a function of AEW phase in each region.Over semiarid portions of tropical Africa, unconditional rain rates are greatest in the northerly phase of AEWs due to the strong adiabatic forcing for ascent. Along the Guinea Coast, the western coast of Africa, and over the east Atlantic—where forcing for ascent is weaker—rainfall is shifted toward the trough where the air is moist. Significant contrasts in the characteristics of convection as a function of AEW phase—comparable in magnitude to regional contrasts—are also observed. In all regions, large and high echo-top convective systems are more sensitive to AEW phase than small and low echo-top systems. In semiarid region.
Deformation behavior and different microstructure evolution during high-temperature compression of a Ti3Al-based alloy

The high-temperature deformation behavior and microstructure evolution of Ti-14Al-21Nb alloy were studied by thermal compression at different strain rates and temperatures. Based on the experimental data, the constitutive equation of this titanium alloy under the experimental conditions was established, and the result fits the experimental stress well. Processing map and microstructure development were researched, microstructure evolution law is closely related to deformation parameters. The schematic of microstructure evolution has been obtained based on a combination of processing map and microstructure evolution, which can be used to predict the microstructure development. There are five domains in the processing map, which correspond to different microstructure evolution mechanisms. Lamellar α phase fracturing at 1080 °C and 0.05–0.5 s−1, and the globularization of α phase occur gradually with the decrease of strain rate. Dynamic recrystallization is the main microstructure evolution mechanism at the strain rates of 0.005–0.05 s−1 and the temperatures of 1140–1170 °C.
Generalized geometric modeling of tubular and flat braided structures with arbitrary floating length and multiple filaments

This paper provides a critical overview about the state of the art in the area of three-dimensional modeling of braided structures. It gives a generalized geometrical approach for modeling braided structures with arbitrary floating length and filaments in the yarn. The approach is tested with large set of structures of different types. Subsequently, one of the simulated geometries is compared with the real geometry of braided tube.
Phase separation in gene transcription control

Phase separation provides a general mechanism for the formation of biomolecular condensates, and it plays a vital role in regulating diverse cellular processes, including gene expression. Although the role of transcription factors and coactivators in regulating transcription has long been understood, how phase separation is involved in this process is just beginning to be explored. In this review, we highlight recent advance in elucidating the molecular mechanisms and functions of transcriptional condensates in gene expression control. We discuss the different condensates formed at each stage of the transcription cycle and how they are dynamically regulated in response to diverse cellular and extracellular cues that cause rapid changes in gene expression. Furthermore, we present new findings regarding the dysregulation of transcription condensates and their implications in human diseases.
Stoma and peristomal complications: a rapid overview of the literature

Complications of the stoma complex are estimated to occur in 20-70% of the ostomized population. These studies, however, appear to show contradictions in terms of definitions of the same complications, making the results of the analyses of incidence and prevalence of the phenomenon inconsistent with each other. The absence of clear and unambiguous definitions, does not allow clear evidence to be defined in science; moreover, this is reflected in the absence of a standardized clinical-care approach, which inevitably hinders the spread of an organizational and methodological culture aimed at the wellness and autonomy of the subject. In order to overcome this obstacle, different classifications of complications have been proposed throughout the years, differentiating these exclusively into macro categories, without delving into them in detail. In this regard, this review aims to clearly define, from the general to the particular, the individual complications of the stoma complex so as to provide nurses an instrument that can help them in the prevention and recognition of these.
Performance analysis of SURF descriptor with different local region partitions

Several local region partition methods for Speeded Up Robust Features(SURF) descriptors were researched to reduce their dimensions and increase the matching speeds and robustnesses of SURF based matching algorithms.With reference to existing local region partition methods of Scale Invariant Feature Transform(SIFT) and SURF descriptors,the local regions were divided into grids(original SURF),triangles,and sectors.First,the influences of scale change and rotation of the image on the matching performance of SURF descriptors were analyzed.Then,a method to construct the SURF descriptors with local region partitions in triangles and sectors were proposed,and matching experiments were performed.The SURF descriptors with different local region partitions were compared.The experiment results show that the performance of the sector partition based SURF descriptor is better than those of triangle partition and grid partition(original SURF) based SURF descriptors.The performance of SURF descriptors with 6-sector partition,8-sector partition,12-sector partition and triangle partition is better than that of original one,and the dimensions of these new descriptors are 40,32,16 and 32 lower than that of original SURF(64 dimensions).
Intrinsic, Extrinsic Rewards and Job Satisfaction: Role of Job Performance and Creative Performance

Despite the importance of motivation and job satisfaction, scholars have yet to identify how different types of motivation relate to job satisfaction. Building on self-determination theory, this study explores the relationship between intrinsic and extrinsic rewards, job performance, creative performance, and job satisfaction. This study proposes job performance and creative performance as potential mediators through which intrinsic and extrinsic rewards relate to job satisfaction. Data collected from 166 employees in India were used to test the hypothesis. To accomplish this objective, a questionnaire was distributed, and these relationships were tested through Structured Equation Modeling using SPSS software. This study revealed that intrinsic and extrinsic rewards positively influence job performance. In contrast, only intrinsic rewards positively influence creative performance, and extrinsic rewards do not have a significant influence on creative performance. The relationship between job performance and job satisfaction is statistically significant, and the relationship between creative performance and job satisfaction is statistically significant. This paper expands the external validity of previous research results of Western samples by finding the positive influence of intrinsic, extrinsic rewards indirect effects on job satisfaction.
Stacking Interaction in DNA Molecule

This paper deals with the stacking interaction in DNA molecule. We offer a systematic analysis of a parameter representing this interaction. We rely on the PBD model of DNA and assume that readers are familiar with it. Hence, in Section 2, we very briefly explain some features of the model that are important for this paper. In Section 3 we estimate the smallest value of the parameter mentioned above. This estimation is systematic, done for a couple of possible cases. We show that most of the values that can be found in literature are underestimated. Finally, in Section 4, we offer an experiment proposal that can be carried out in order to determine the value of a crucial parameter. We close the paper with summary and concluding remarks in Section 5.
Evaluation and intercomparison of multiple satellite-derived and reanalysis downward shortwave radiation products in China

ABSTRACT Downward shortwave radiation (DSR) is a critical variable in energy balance driving Earth’s surface processes. Satellite-derived and reanalysis DSR products have been developed and continuously improved during the last decades. However, as those products have different temporal resolutions, their performances in different time scales have not been well-documented, particularly in China. This study intended to evaluate several DSR products across multiple time scales (i.e. instantaneous, 1-hourly, daily, and monthly average) and ecosystems in China. Six DSR products, including GLASS, BESS, CLARA-A2, MCD18A1, ERA5 and MERRA-2, were evaluated against ground measurements at Chinese Ecosystem Research Network (CERN) and integrated land-atmosphere interaction observation (TPDC) sites from 2009 to 2012. The instantaneous DSR of MCD18 showed a root mean square error (RMSE) of 146.02 W/m2. The hourly RMSE of ERA5 (155.52 W/m2) was largely smaller than MERRA-2 (188.53 W/m2). On the daily and monthly scale, BESS had the most optimized accuracy among the six products (RMSE of 36.82 W/m2). For the satellite-derived DSR products, the monthly accuracy at CERN can meet the threshold accuracy requirement set by World Meteorological Organization (WMO) for Global Numerical Weather Prediction (20 W/m2).
GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion

Exercise is a first-line treatment for type 2 diabetes and preserves β-cell function by hitherto unknown mechanisms. We postulated that proteins from contracting skeletal muscle may act as cellular signals to regulate pancreatic β-cell function. We used electric pulse stimulation (EPS) to induce contraction in C2C12 myotubes and found that treatment of β-cells with EPS-conditioned medium enhanced glucose-stimulated insulin secretion (GSIS). Transcriptomics and subsequent targeted validation revealed growth differentiation factor 15 (GDF15) as a central component of the skeletal muscle secretome. Exposure to recombinant GDF15 enhanced GSIS in cells, islets, and mice. GDF15 enhanced GSIS by upregulating the insulin secretion pathway in β-cells, which was abrogated in the presence of a GDF15 neutralizing antibody. The effect of GDF15 on GSIS was also observed in islets from GFRAL-deficient mice. Circulating GDF15 was incrementally elevated in patients with pre- and type 2 diabetes and positively associated with C-peptide in humans with overweight or obesity. Six weeks of high-intensity exercise training increased circulating GDF15 concentrations, which positively correlated with improvements in β-cell function in patients with type 2 diabetes. Taken together, GDF15 can function as a contraction-induced protein that enhances GSIS through activating the canonical signaling pathway in a GFRAL-independent manner. Article Highlights Exercise improves glucose-stimulated insulin secretion through direct interorgan communication. Contracting skeletal muscle releases growth differentiation factor 15 (GDF15), which is required to synergistically enhance glucose-stimulated insulin secretion. GDF15 enhances glucose-stimulated insulin secretion by activating the canonical insulin release pathway. Increased levels of circulating GDF15 after exercise training are related to improvements in β-cell function in patients with type 2 diabetes.
A Note on the Bottleneck Counting Argument (Extended Abstract)

Both the bottleneck counting argument [5, 61 and Razborov’s approximation method [I, 3,8] have been used to prove exponential lower bounds for monotone circuits. We show that under the monotone circwit model for every proof by the approximation method, there is a bottleneck counting proof and vice versa. We also illustrate the elegance of the bottleneck counting technique with a simple self-explained example: the proof of a (previously known) lower bound for the 3-CL.IQUE,, problem by the bottleneck counting argument.