Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic Na+/H+ exchanger 1 (NHE1) - calmodulin complexes of varying stoichiometry and structure regulate Ca2+-dependent NHE1 activation

Calmodulin (CaM) engages in Ca 2+ -dependent interactions with numerous proteins, including a still incompletely understood physical and functional interaction with the human Na + / H + -exchanger NHE1. Using nuclear magnetic resonance (NMR) spectroscopy, isothermal titration calorimetry, and fibroblasts stably expressing wildtype and mutant NHE1, we discovered multiple accessible states of this functionally important complex existing in different NHE1:CaM stoichiometries and structures. We determined the NMR solution structure of a ternary complex in which CaM links two NHE1 cytosolic tails. In vitro , stoichiometries and affinities could be tuned by variations in NHE1:CaM ratio and calcium ([Ca 2+ ]) and by phosphorylation of S648 in the first CaM-binding a -helix. In cells, Ca 2+ -CaM-induced NHE1 activity was reduced by mimicking S648 phosphorylation and by mutation of the first CaM-binding a -helix, whereas it was unaffected by inhibition of Akt, one of several kinases phosphorylating S648. Our results demonstrate a diversity of NHE1:CaM interaction modes and suggest that CaM may contribute to NHE1 dimerization and thereby augment NHE1 regulation. We propose that a similar structural diversity is of relevance to many other CaM complexes.
Fully Empirical Autotuned QR Factorization For Multicore Architectures

Tuning numerical libraries has become more difficult over time, as systems get more sophisticated. In particular, modern multicore machines make the behaviour of algorithms hard to forecast and model. In this paper, we tackle the issue of tuning a dense QR factorization on multicore architectures. We show that it is hard to rely on a model, which motivates us to design a fully empirical approach. We exhibit few strong empirical properties that enable us to efficiently prune the search space. Our method is automatic, fast and reliable. The tuning process is indeed fully performed at install time in less than one and ten minutes on five out of seven platforms. We achieve an average performance varying from 97% to 100% of the optimum performance depending on the platform. This work is a basis for autotuning the PLASMA library and enabling easy performance portability across hardware systems.
Myocardial Infarction and Sudden Cardiac Death in Olmsted County , Minnesota , Before and After Smoke-Free Workplace Laws

Methods: To evaluate the population impact of smokefree laws, we measured, through the Rochester Epidemiology Project, the incidence of MI and sudden cardiac death in Olmsted County during the 18-month period before and after implementation of each smoke-free ordinance. All MIs were continuously abstracted and validated, using rigorous standardized criteria relying on biomarkers, cardiac pain, and Minnesota coding of the electrocardiogram. Sudden cardiac death was defined as out-of-hospital deaths associated with coronary disease.
Dynamic Enterprise Architecture Capabilities and Organizational Benefits: An empirical mediation study

In recent years the literature has put a greater emphasis on theory building in the context of Enterprise Architecture, EA, research. Specifically, scholars tend to focus on EA-based capabilities that organize and deploy organization-specific resources to align strategic objectives with the particular use of technology. Despite the growth in EA studies, substantial gaps remain in the literature. The most noteworthy gaps are that the conceptualization of EA-based capabilities still lacks a firm base in theory and that there is no conclusive evidence on how EA-based capabilities drive business transformation and deliver benefits to the firm. Therefore, this study focuses on EA-based capabilities, using the dynamic capabilities view as a theoretical foundation, develops and tests a new research model that explains how dynamic enterprise architecture capabilities lead to organizational benefits. Hypotheses associated with the research model are tested using a dataset that contains responses from 299 CIOs, IT managers, and lead architects. Results show that dynamic enterprise architecture capabilities positively influence the firm's process innovation and business/IT alignment. These mediating forces are both positively associated with organizational benefits. This study advances our understanding of how to efficaciously de-lineate dynamic enterprise architecture capabilities in delivering benefits to the organization.
UvA-DARE (Digital Academic Repository) Occupancy Dependency of Maxwell–Stefan Diffusivities in Ordered Crystalline Microporous Materials

: Molecular dynamics simulation data for a variety of binary guest mixtures (H 2 /CO 2 , Ne/CO 2 , CH 4 /CO 2 , CO 2 /N 2 , H 2 /CH 4 , H 2 /Ar, CH 4 /Ar, Ar/Kr, Ne/Ar, CH 4 /C 2 H 6 , CH 4 /C 3 H 8 , C 2 H 6 C 3 H 8 , CH 4 / n C 4 H 10 , and CH 4 / n C 5 H 11 ) in zeolites (MFI, BEA, ISV, FAU (all-silica), NaY, NaX, LTA, CHA, DDR) and metal − organic frameworks (MOFs) (IRMOF-1, CuBTC, MgMOF-74) show that the Maxwell − Stefan (M − S) di ﬀ usivities, Đ 1 , Đ 2 , Đ 12 , are strongly dependent on the molar loadings. The main aim of this article is to develop a fundamental basis for describing the loading dependence of M − S di ﬀ usivities. Using the ideal adsorbed solution theory, a thermodynamically rigorous de ﬁ nition of the occupancy, θ , is derived; this serves as a convenient proxy for the spreading pressure, π , and provides the correct metric to describe the loading dependence of di ﬀ usivities. Con ﬁ gurational-bias Monte Carlo simulations of the unary adsorption isotherms are used for the calculation of the spreading pressure, π , and occupancy, θ . The M − S di ﬀ usivity, Đ i , of either constituent in binary mixtures has the same value as that for unary di ﬀ usion, provided the comparison is made at the same θ . Furthermore, compared at the same value of θ , the M − S di ﬀ usivity Đ i of any component in a mixture does not depend on it partner species. The Đ i versus θ dependence is amenable to simple interpretation using lattice-models. The degree of correlations
ANALISIS PENGARUH AKUNTABILITAS DAN TRANSPARANSI PENGELOLAAN ANGGARAN PENDAPATAN DAN BELANJA SEKOLAH (APBS) TERHADAP PARTISIPASI ORANG TUA MURID

Penelitian ini bertujuan untuk mengetahui pengaruh akuntabilitas dan transparansi pengelolaan anggaran pendapatan dan belanja sekolah terhadap partisipasi orang tua murid dalam pembiayaan pendidikan. Objek penelitian adalah SMA Negeri kota Depok, Jawa Bara,t Indonesia. Instrumen penelitian adalah kuesioner, dimana orang tua murid, guru, Kepala Sekolah, Wakil Kepala Sekolah, bendahara, guru dan komite sekolah menjadi responden. Variabel penelitian akuntabilitas, transparansi pengelolaan, dan partisipasi orang tua murid merupakan variabel laten, dengan demikian model persamaan struktural digunakan sebagai alat analisis data. Hasil Penelitian menunjukkan bahwa akuntabilitas dan transparansi pengelolaan anggaran pendapatan dan belanja sekolah mempunyai pengaruh positif terhadap partisipasi orang tua murid dalam pembiayaan pendidikan.
Evolution of IFN-g response against mycobacterial antigens used for the diagnosis of bovine tuberculosis in BCG vaccinated cattle under a natural transmission setting in central Chile

Bovine tuberculosis (bTB) is a chronic disease of animals mainly caused by Mycobacterium bovis , a zoonotic pathogen that generates economic losses in the milk and meat industry. In central Chile, the Metropolitan Region concentrates dairy herds with the highest bTB prevalence of the country and the official veterinary service has supported the evaluation of the M. bovis Bacillus Calmette-Guerin (BCG) vaccine in this area with the replacement of tuberculin purified protein derivative (PPDs) by the DIVA (Differentiating Infected from Vaccinated Animals) peptides for the bTB diagnosis in the herds. This study aimed to describe the IFN-g response against PPDs (bovine and avian PPD) and DIVA antigenic cocktails (ESAT-6/CFP-10 and Rv3615c) in BCG vaccinated 11-month-old heifers under a natural transmission scenario. Sixty-two animals were vaccinated via subcutaneous route with a 2-8 x 10 5 colony forming units of BCG Russia strain and 60 control animals received sterile saline. Blood sampling was performed at time 0, previous to vaccination, and then at 3, 6, 9, 12, 15 and 18 months post-inoculation. The follow up of the IFN-g response in animals determined that the BCG vaccination interferes with the diagnosis of bTB using the traditional bovine PPD between 9 and 12 months post-inoculation. Furthermore, the sensitization with non-tuberculous mycobacteria (NTM) was also interfering the diagnosis relying in PPDs, suggesting the need of using DIVA antigens under this epidemiological condition, whether or not the BCG vaccine is administered in cattle, in order to improve the accuracy of bTB diagnosis in central Chile.
Circular Economy in SMEs: The Role of Commitment to Sustainability and Digitalization

: Small and medium-sized enterprises (SMEs) are a decisive part of the efforts against climate change. However, they are late in terms of sustainability and circular economy (CE). Little is known about the factors that facilitate the implementation of CE practices in SMEs. Due to CE leading to cost savings, new business models or reputation gains, companies can achieve a competitive advantage. To realize this competitive advantage the strategic orientation of a firm is pointed out. Various theoretical papers have shown how CE can be enabled and how it can be inhibited. However, empirical studies that support the existing literature are lacking. The goal of this paper is to investigate the influence of two mechanisms, namely commitment to sustainability (CtS) and digitalization as strategic orientations on CE implementation. Therefore, we conduct a study with a self-developed sample of 754 German SMEs. Using multiple linear regression analyses, the results show that digitalization and CtS positively influence CE implementation in SMEs. Interestingly, the complementary effect of pursuing a dual strategy toward digitalization and sustainability is not significant for CE implementation. Our study contributes to the CE literature by giving a nuanced understanding of various antecedents of CE implementation. This study provides several approaches for managers of SMEs to improve their CE practices. First, digitalization is indeed an effective tool for implementing CE practices. Therefore, practitioners should strengthen their digitalization efforts when considering increased CE implementation. Second, a general focus on sustainability increases the implementation of CE practices. Therefore, practitioners should raise awareness of sustainability throughout the organization. Third, the combined focus on CtS and digitalization needs to be carefully considered. To implement CE, digitalization should be embedded in the sustainability strategy. Due to the liability of smallness, SMEs should seek their resources for digitalization and sustainability commitment not only within but also outside the company boundaries.
The Faunal Succession in the Carboniferous Limestone and Bowland Shales at Clitheroe and Pendle Hill, (Lancashire)

The present paper records an attempt to establish a faunal sequence in the Carboniferous deposits in the Clitheroe district of North-East Lancashire. The area dealt with forms a small part of the large spread of Carboniferous strata lying south of the Craven Faults. The rocks of this region have been thrown into a series of more or less parallel folds with a general trend from east-north-east to west-south-west. The most important upfold is the Clitheroe Anticline, dissected by the Ribble, which runs west-south-westwards in the neighbourhood of Clitheroe, exposing the Carboniferous Limestone along the axis. On the north-western flank the synclinal Millstone-Grit hills of Longridge, Waddington, and Grindleton connect the Clitheroe Anticline with that of Slaidburn, in Bowland; while on the south-east there is a continuous succession through the grits of the Pendle Range to the Coal Measures of the Burnley Basin. The ground which has been mapped in detail forms that portion of the south-eastern limb of the Clitheroe Anticline which is included between the Twiston and Clitheroe Faults, along with most of the scarp-face of Pendle Hill below the Pendle Top Grit. Two small patches occur on the Yorkshire side of the county boundary. The low ground between the Ribble and Pendle Hill is occupied by the Clitheroe Limestone and the overlying ‘Shales-with-Limestone’ or Worston Shale Series. The upper part of the Clitheroe Limestone contains some of the typical reef-knolls which rise abruptly above the general level of the ground. One of these, Worsaw Hill, attains a height
La transparencia de las empresas en internet para la confianza de los accionistas e inversores: un análisis empírico

La globalizacion de la economia y los escandalos financieros en algunas empresas han provocado que la informacion sobre el funcionamiento y el gobierno de las empresas sea critica para la confianza en estas y para el buen funcionamiento del mercado de capitales. La informacion sobre las empresas no solo reduce los riesgos de las inversiones, sino que reduce las asimetrias en la informacion e incrementa la transparencia de la empresa frente a todos los stakeholders, especialmente accionistas e inversores. El uso de la tecnologia de internet permite a las empresas poner a disposicion de los terceros interesados, en cualquier parte del mundo, un gran volumen de informacion, con un bajo coste. Lo mas importante es que permite restablecer la confianza perdida en la empresa. En este trabajo se crea y analiza empiricamente un indice de transparencia, util para medir la confianza que las empresas estan transmitiendo a traves de internet.
Analysis of interior rotor for high-speed brushless DC motor using finite element method

The permanent magnet of brushless DC (BLDC) motor is ideally suited for high-speed application due to its superior performance and efficient as compared to other types of electrical motors. However, to operate in high-speed operation, the rotors that hold the magnet must be able to withstand high centrifugal force. Due to that, the main objective of this project is to design and develop the suitable rotor for high-speed BLDC motor through the finite element method (FEM) Ansys Maxwell modeling software. In addition, this project is also carried out to determine the ability of the modeled software to reach the high-speed performances in terms of cogging torque and induce voltage. In this project, the selected BLDC motor was fabricated and measured experimentally. The result showed that the designed rotor can achieve speed of almost 14,500 rpm.
Temporal and spatial variability of surface ozone at Delhi and Antarctica

This study deals with the temporal and spatial variability of 365 days; hourly mean surface ozone data for three different locations, New Delhi (a site of intense anthropogenic activity), Syowa and McMurdo stations in Antarctica (sites of clean background air). The analysis not only shows the seasonal and diurnal variation of O3 over New Delhi and Antarctica, but also provides statistics of means and variability on a temporal scale. Eight‐hour (9–17 h) surface O3 concentration at New Delhi (2001) was recorded, which was 59% of the WHO (80 ppb) ambient air quality standard for ozone. Likewise, the monthly mean of daily maximum O3 during April and November (2001) was observed, which was 97% of the WHO ambient air quality standard for ozone that indicates the serious ozone pollution in New Delhi. Mean rate of daytime photochemical production of surface O3 at Delhi (2001) has been observed around 7.1 ppb h−1 between 6 and 12 h, while, Syowa and McMurdo stations showed photochemical loss of surface O3 during daylight hours of about 1 ppb and 0.2 ppb, respectively. The diurnal trend observed during summer at Syowa station shows a sign of daytime photochemical depletion. The photochemical loss of surface O3 during summer months with respect to the winter maximum ozone was observed to be about 56% and 64% at Syowa and McMurdo stations, respectively. The day‐to‐day variability at Syowa and McMurdo station suggests that the major loss term is a process in the sea ice zone. Copyright © 2006 Royal Meteorological Society
What is cryptography?

Cryptography's aim is to construct schemes or protocols that can still accomplish certain tasks even in the presence of an adversary. A basic task in cryptography is to enable users to communicate securely over an insecure channel in a way that guarantees their transmissions' privacy and authenticity. Providing privacy and authenticity remains a central goal for cryptographic protocols, but the field has expanded to encompass many others, including e-voting, digital coins, and secure auctions. This paper explains what cryptography is about and how we can scientifically justify a cryptographic scheme's security.
Will the City Rise Again? The Contested Geography of Housing Reconstruction in Post-Disaster Haiti

This paper examines the contested geography of post-disaster housing reconstruction in Haiti. Drawing on interviews with representatives of 48 organizations, it identifies three spatial preferences regarding reconstruction: urban, non-urban, and mixed. Organizations favoring urban versus non-urban rebuilding differed markedly in their financial resources and voice. Many intergovernmental organizations and large international non-governmental organizations (NGOs)—the organizations that most favored non-urban rebuilding—held relatively anti-urban perspectives. Small international and Haitian NGOs were more likely to see Port-au-Prince as a suitable site for reconstruction and express positive opinions about urban conditions more generally. The findings indicate that much of the formal housing reconstruction effort, particularly as led by large, well-funded and politically powerful organizations, will be directed to the urban periphery and countryside. This suggests Port-au-Prince may continue to face the same challenges of unplanned growth that have led some organizations to find it an undesirable setting for reconstruction in the first place.
Biodiversity of Fabaceae in the Brazilian Amazon and Its Timber Potential for the Future

The vegetation of Neotropical forest of Amazonian region is one representative part of global biodiversity in Fabaceae, with numerous species for wood production, oil, fruits, or other forests products or same ecosystemic services for agricultural production. This chapter gathers information on the biodiversity of Fabaceae of the Amazon, highlighting the timber species in the set of existing plant genetic resources. Systematic information emphasizes the importance of basic forestry information, and potential for cultivation in agroecosystems or for management, forestry and reforestation. The product of the highest economic value of the Fabaceae of the Brazilian Amazon is wood, which is sold in local, regional markets and exported to other countries. Also noteworthy is the ability acquired evolutionarily by many Fabaceae: the symbiotic fixation of N2 with soil bacteria of the Rhizobia group, character particularly important for soil recuperation or reforestation.
Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study)

Objective To examine use of magnetic resonance imaging (MRI) of knees with no radiographic evidence of osteoarthritis to determine the prevalence of structural lesions associated with osteoarthritis and their relation to age, sex, and obesity. Design Population based observational study. Setting Community cohort in Framingham, MA, United States (Framingham osteoarthritis study). Participants 710 people aged >50 who had no radiographic evidence of knee osteoarthritis (Kellgren-Lawrence grade 0) and who underwent MRI of the knee. Main outcome measures Prevalence of MRI findings that are suggestive of knee osteoarthritis (osteophytes, cartilage damage, bone marrow lesions, subchondral cysts, meniscal lesions, synovitis, attrition, and ligamentous lesions) in all participants and after stratification by age, sex, body mass index (BMI), and the presence or absence of knee pain. Pain was assessed by three different questions and also by WOMAC questionnaire. Results Of the 710 participants, 393 (55%) were women, 660 (93%) were white, and 206 (29%) had knee pain in the past month. The mean age was 62.3 years and mean BMI was 27.9. Prevalence of “any abnormality” was 89% (631/710) overall. Osteophytes were the most common abnormality among all participants (74%, 524/710), followed by cartilage damage (69%, 492/710) and bone marrow lesions (52%, 371/710). The higher the age, the higher the prevalence of all types of abnormalities detectable by MRI. There were no significant differences in the prevalence of any of the features between BMI groups. The prevalence of at least one type of pathology (“any abnormality”) was high in both painful (90-97%, depending on pain definition) and painless (86-88%) knees. Conclusions MRI shows lesions in the tibiofemoral joint in most middle aged and elderly people in whom knee radiographs do not show any features of osteoarthritis, regardless of pain.
Palaeomagnetic studies of the Orcadian Basin

Synopsis After removal of recently acquired viscous components, two main groups of remanent directions have been identified in Devonian rocks from the Orcadian Basin. One group, A, has a SSE, fairly shallow, reversely magnetized direction of moderate stability and is found in most rocks when partially demagnetized at 300°C or 30 mT. The other group, B, is of mixed polarity, but mostly showing southerly, horizontal directions that are only isolated close to the noise-level of measurement, usually at temperatures above 550°C. Only a few other unrelated components have been isolated. There is dispute concerning the age of both groups. The age of Group A has been suggested variously as between Devonian and Tertiary. The physical reality of Group B has been disputed, but has been considered to originate in the Devonian. Comparison with ‘accepted’ poles suggest that A is probably Permian and B, if real, of mid-Carboniferous age. Of the remaining directions, only those of the Orkney-Shetland volcanics appear to correspond with a possible Devonian age. An evaluation of the available palaeomagnetic data shows no evidence for major post Devonian motions along the Great Glen Fault, but suggests that the Orcadian Basin moved from about 20°S in the early Devonian, to c. 15°S in late Devonian times, passing across the equator in early Upper Carboniferous times.