Miracle-dz/UniFAR-FTUs huggingface dataset:
Regression trees and decision rules applied to the study of perplexity: Issues and methods

This paper explores the use of the CRT (Classification and Regression Tree) methodology to analyse data from a fuzzy rating scale-based questionnaire. Based upon a questionnaire to assess the state of perplexity in mathematics undergraduate students, the rule structure obtained from the CRT analysis is reported. We anticipate these findings may be of interest both to evaluate the interplay between cognition and affect as well as to researchers in the Fuzzy Logic field.
Relationship of School Attachment and Parents’ Attachment Styles with the School Performance of Female High School Students

: This study was conducted with the aim of examining the relationship of students’ school attachment and parents’ attachment styles with the school performance of female high school students of the city of Bandar Abbas in the educational year of 2012-13. The research method of the present study was descriptive correlational and descriptive survey. The population in this research included the female high school students of the city of Bandar Abbas in the educational year of 2012-13. The statistical sample of the present study was composed of 380 students selected through multistage random sampling. In this study, two standard questionnaires, i.e. Brown and Evans’s School Attachment Questionnaire (SAQ) and Collins and Read’s Attachment Styles Questionnaire (ASQ) as well as the average scores of students were used to assess their school performance. The results indicated that there is a relationship of school attachment and parents’ attachment styles with the school performance of female high school students of the city of Bandar Abbas and the components of school attachment and parents’ attachment styles can by and large explain almost 6.1% of school performance variance.
The HEART Score for Suspected Acute Coronary

at 3 time points (p 1⁄4 0.694). In the double-RFA group, the fenestration size increased at 2 months (6.0 3.5 mm; p 1⁄4 0.029) and remained stable subsequently (6.2 3.3 mm at 3 months; p 1⁄4 0.268). The location and patency of fenestration were further confirmed pathologically, and the area of fenestration was larger in the double-RFA group than single-RFA group (13.2 9.5 mm vs. 3.2 2.9 mm; p 1⁄4 0.033). Our findings suggest that RFA has the potential to prevent the spontaneous closure of created interatrial communication with BAS, and this could be attributed to the irreversible damage around the fenestration rim. Furthermore, double RFA created larger fenestration than single RFA with the same BAS procedure, which was probably associated with reduced elastic recoil and post-operative remodeling of local tissue. Although the follow-up was only 3 months, the fenestration size was stable after 2 months of atrial septostomy in both RFA groups. In conclusion, the combination of BAS and RFA is feasible and effective to create a stable interatrial communication in a swine model. Further research is required to investigate the clinical application in selected patients.
A New Two-Wing Chaotic System with Line Equilibrium, its Analysis, Adaptive Synchronization and Circuit Simulation

This work reports a new three-dimensional chaotic system with line equilibrium and two equilibrium points on the ( x , y ) plane. A qualitative analysis has been conducted on the system with the aid of bifurcation diagram, Lyapunov exponents spectrum, etc. It is shown that the new chaotic system is dissipative. Since the new chaotic system has inﬁnitely many equilibrium points, it exhibits hidden attractor. Using adaptive control, global chaos synchronization of the new chaotic system with itself is established using Lyapunov stability theory. Finally, a circuit simulation of the new chaotic system with line equilibrium is carried out via MultiSim and the feasibility of implementing the new chaotic system is established. models ([14]-[16]), ﬁnance systems ([17]-[20]), oscillations ([21]-[28]), neural networks ([29]-[31]), chemical reactions ([32]-[35]), steganography ([36]-[37]), cryptography ([38]-[41]), robotics ([42]-[43]), circuits ([44]-[55]),
Hyperbaric oxygen treatment is associated with a decrease in cytokine levels in patients with necrotizing softâ•’tissue infection

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society 1Department of Anaesthesia, Hyperbaric Unit, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark 2Laboratory of Molecular Medicine, Department of Clinical Immunology Section 7631, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark 3Department of Intensive Care, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Migrating bubble synthesis promotes mutagenesis through lesions in its template

Abstract Break-induced replication (BIR) proceeds via a migrating D-loop for hundreds of kilobases and is highly mutagenic. Previous studies identified long single-stranded (ss) nascent DNA that accumulates during leading strand synthesis to be a target for DNA damage and a primary source of BIR-induced mutagenesis. Here, we describe a new important source of mutagenic ssDNA formed during BIR: the ssDNA template for leading strand BIR synthesis formed during D-loop migration. Specifically, we demonstrate that this D-loop bottom template strand (D-BTS) is susceptible to APOBEC3A (A3A)-induced DNA lesions leading to mutations associated with BIR. Also, we demonstrate that BIR-associated ssDNA promotes an additional type of genetic instability: replication slippage between microhomologies stimulated by inverted DNA repeats. Based on our results we propose that these events are stimulated by both known sources of ssDNA formed during BIR, nascent DNA formed by leading strand synthesis, and the D-BTS that we describe here. Together we report a new source of mutagenesis during BIR that may also be shared by other homologous recombination pathways driven by D-loop repair synthesis.
Associations of blood pressure components with risks of cardiovascular events and all‐cause death in a Chinese population: A Prospective Study

The associations of blood pressure components with cardiovascular risks and death remain unclear, and the definition of wide pulse pressure (PP) is still controversial. Using data from 1257 participants without a history of cardiovascular disease, who were followed for 4.84 years, we performed multivariable Cox regression analyses to assess how systolic blood pressure (SBP), diastolic blood pressure (DBP), and PP contribute to risks of cardiovascular events and all‐cause death. Among all participants, SBP and PP were significantly associated with the risks of cardiovascular events and all‐cause death (all p < .05). DBP was not significantly associated with the risk of all‐cause death; rather, it was only associated with a marginally significant 1% increased risk for cardiovascular events (p = 0.051). In participants aged < 65 years, DBP was significantly associated with a 3% increased risk for cardiovascular events (hazard ratio [HR]: 1.03, 95% confidence interval [95% CI]: 1.01–1.06). The association between PP and cardiovascular events appeared to be J‐shaped in comparison to participants with the lowest‐risk PP (50–60 mmHg), with adjusted HRs of 1.71 (95% CI: 1.03–2.85), 1.63 (95% CI: 1.00–2.68), and 2.13 (95% CI: 1.32–3.43) in the <50, 60.0–72.5, and ≥72.5 mmHg subgroups, respectively. The optimal cutoff points of a wide PP for predicting the risks of cardiovascular events and all‐cause death were 70.25 and 76.25 mmHg, respectively. SBP and PP had a greater effect on cardiovascular risk, whereas DBP independently influenced cardiovascular events in middle‐aged participants. Considerable PP alterations should be avoided in antihypertensive treatment.
Predicting Hydration Status Using Machine Learning Models From Physiological and Sweat Biomarkers During Endurance Exercise: A Single Case Study

Improper hydration routines can reduce athletic performance. Recent studies show that data from noninvasive biomarker recordings can help to evaluate the hydration status of subjects during endurance exercise. These studies are usually carried out on multiple subjects. In this work, we present the first study on predicting hydration status using machine learning models from single-subject experiments, which involve 32 exercise sessions of constant moderate intensity performed with and without fluid intake. During exercise, we measured four noninvasive physiological and sweat biomarkers including heart rate, core temperature, sweat sodium concentration, and whole-body sweat rate. Sweat sodium concentration was measured from six body regions using absorbent patches. We used three machine learning models to determine the percentage of body weight loss as an indicator of dehydration with these biomarkers and compared the prediction accuracy. The results on this single subject show that these models gave similar mean absolute errors, while in general the nonlinear models slightly outperformed the linear model in most of the experiments. The prediction accuracy of using the whole-body sweat rate or heart rate was higher than using core temperature or sweat sodium concentration. In addition, the model trained on the sweat sodium concentration collected from the arms gave slightly better accuracy than from the other five body regions. This exploratory work paves the way for the use of these machine learning models to develop personalized health monitoring together with emerging, noninvasive wearable sensor devices.
Luminescence and Length Control in Nonchelated d8‐Metallosupramolecular Polymers through Metal‐Metal Interactions

Abstract Supramolecular polymers (SPs) of d8 transition metal complexes have received considerable attention by virtue of their rich photophysical properties arising from metal‐metal interactions. However, thus far, the molecular design is restricted to complexes with chelating ligands due to their advantageous preorganization and strong ligand fields. Herein, we demonstrate unique pathway‐controllable metal‐metal‐interactions and remarkable 3MMLCT luminescence in SPs of a non‐chelated PtII complex. Under kinetic control, self‐complementary bisamide H‐bonding motifs induce a rapid self‐assembly into non‐emissive H‐type aggregates (1A). However, under thermodynamic conditions, a more efficient ligand coplanarization leads to superiorly stabilized SP 1B with extended Pt⋅⋅⋅Pt interactions and remarkably long 3MMLCT luminescence (τ 77 K=0.26 ms). The metal‐metal interactions could be subsequently exploited to control the length of the emissive SPs using the seeded‐growth approach.
POC1A, prognostic biomarker of immunosuppressive microenvironment in cancer

POC1 centriolar protein A (POC1A) effect in pan-cancer remains uncertain. The POC1A expression in normal and tumor tissues underwent analysis in this study utilizing data from the Genotype-Tissue Expression (GTEx) project and the Cancer Genome Atlas (TCGA) database. POC1A prognostic value and clinicopathological features were assessed utilizing the TCGA cohort. The relationship between immunological cell infiltration and POC1A of TCGA samples downloaded from TIMER2 and ImmuCellAI databases were observed. The relation between POC1A and immunological checkpoints genes, microsatellite instability (MSI) as well as tumor mutation burden (TMB) was also evaluated. Additionally, gene set enrichment analysis (GSEA) was utilized for exploring POC1A potential molecular mechanism in pan-cancer. In almost all 33 tumors, POCA1 showed a high expression. In most cases, high POC1A expression was linked significantly with a poor prognosis. Additionally, Tumor immune infiltration and tumors microenvironment were correlated with the expression of POC1A. In addition, TMB and MSI, as well as immune checkpoint genes in pan-cancer, were related to POC1A expression. In GSEA analysis, POC1A is implicated in cell cycle and immune-related pathways. These results might elucidate the crucial roles of POC1A in pan-cancer as a prognostic biomarker and immunotherapy target.
Genome plasticity driven by aneuploidy and loss of heterozygosity in Trypanosoma cruzi

Trypanosoma cruzi the causative agent of Chagas disease shows a marked genetic diversity and divided into at least six Discrete Typing Units (DTUs). High intra genetic variability has been observed in the TcI DTU, the most widely distributed DTU, where patterns of genomic diversity can provide information on ecological and evolutionary processes driving parasite population structure and genome organization. Chromosomal aneuploidies and rearrangements across multigene families represent an evidence of T. cruzi genome plasticity. We explored genomic diversity among 18 Colombian T. cruzi I clones and 15 T. cruzi I South American strains. Our results confirm high genomic variability, heterozygosity and presence of a clade compatible with the TcIdom genotype, described for strains from humans in Colombia and Venezuela. TcI showed high structural plasticity across the geographical region studied. Differential events of whole and segmental aneuploidy (SA) along chromosomes even between clones from the same strain were found and corroborated by the depth and allelic frequency. We detected loss of heterozygosity (LOH) events in different chromosomes, however, the size and location of segments under LOH varied between clones. Genes adjacent to breakpoints were evaluated, and retrotransposon hot spot genes flanked the beginning of segmental aneuploidies. Our results suggest that T. cruzi genomes, like those of Leishmania, may have a highly unstable structure and there is now an urgent need to design experiments to explore any potential adaptive role for the plasticity observed.
Safety and efficacy of MRI-guided transurethral ultrasound ablation for radiorecurrent prostate cancer in the presence of gold fiducial markers

Background Safety and efficacy of ultrasound prostate ablation for radiorecurrent prostate cancer (PCa) in the presence of gold fiducial markers has not been previously reported. Purpose To evaluate safety, functional, and early-stage oncological outcomes for patients with gold fiducial markers undergoing salvage magnetic resonance imaging (MRI)-guided transurethral ultrasound ablation (sTULSA) for radiorecurrent PCa. Material and Methods Data were acquired from an ethics-approved, single-center phase-1 study. Eight patients with 18 total gold fiducial markers inside the planned treatment volume were identified. MRI controls were performed at three and 12 months, followed by PSMA-PET-CT imaging and biopsies at 12 months. A control cohort of 13 patients who underwent sTULSA without markers were also identified for safety profile comparison. Adverse events were reported using the Clavien-Dindo classification, and questionnaires including EPIC-26, IPSS, and IIEF-5 were collected. Results Of 18 markers, 2 (11%) were directly responsible for poor ultrasound penetration. However, there were no local recurrences at 12 months. PSA, prostate volume, and non-perfused volume all decreased over time. At 12 months, 11/18 (61%) of fiducial markers had disappeared via sloughing. The adverse event profile was similar between both patient cohorts, and when controlled for ablation type, no statistical difference in functional outcomes between the two cohorts was observed. Conclusion Patients with radiorecurrent PCa with intraprostatic gold fiducial markers can be successfully treated with TULSA. The early-stage efficacy of sTULSA for patients with intraprostatic gold markers is encouraging and the safety profile is unaffected by marker presence.
Using social networks to improve team transition prediction in professional sports

We examine whether social data can be used to predict how members of Major League Baseball (MLB) and members of the National Basketball Association (NBA) transition between teams during their career. We find that incorporating social data into various machine learning algorithms substantially improves the algorithms’ ability to correctly determine these transitions in the NBA but only marginally in MLB. We also measure the extent to which player performance and team fitness data can be used to predict transitions between teams. This data, however, only slightly improves our predictions for players for both basketball and baseball players. We also consider whether social, performance, and team fitness data can be used to infer past transitions. Here we find that social data significantly improves our inference accuracy in both the NBA and MLB but player performance and team fitness data again does little to improve this score.
Simultaneous Control of 2DOF Upper-Limb Prosthesis With Body Compensations-Based Control: A Multiple Cases Study

Controlling several joints simultaneously is a common feature of natural arm movements. Robotic prostheses shall offer this possibility to their wearer. Yet, existing approaches to control a robotic upper-limb prosthesis from myoelectric interfaces do not satisfactorily respond to this need: standard methods provide sequential joint-by-joint motion control only; advanced pattern recognition-based approaches allow the control of a limited subset of synchronized multi-joint movements and remain complex to set up. In this paper, we exploit a control method of an upper-limb prosthesis based on body motion measurement called Compensations Cancellation Control (CCC). It offers a straightforward simultaneous control of the intermediate joints, namely the wrist and the elbow. Four transhumeral amputated participants performed the Refined Rolyan Clothespin Test with an experimental prosthesis alternatively running CCC and conventional joint-by-joint myoelectric control. Task performance, joint motions, body compensations and cognitive load were assessed. This experiment shows that CCC restores simultaneity between prosthetic joints while maintaining the level of performance of conventional myoelectric control (used on a daily basis by three participants), without increasing compensatory motions nor cognitive load.
Amplifying the effects of adding extra players during association football game-based scenarios

This study aimed to compare under-18 association football players’ performance (age = 17.7±1.0 years; playing experience = 9.0 ± 3.2 years) when manipulating the number of teammates and opponents during football game-based practices. Time-motion, individual and tactical-related variables were monitored when manipulating conditions with different number of teammates and opponents (11vs11, No-Sup, No-Inf; 11vs12, Low-Sup, Low-Inf; 11vs13, Mod-Sup, Mod-Inf; and 11vs14, High-Sup, High-Inf). Results showed that adding teammates promoted increases in the longitudinal synchronization from No-Sup to Mod-Sup (Cohen’s d with 95% of confidence intervals: 0.25 [0.12; 0.39]; p < .001) and High-Sup (0.61 [0.41; 0.82]; p < .001), while decreases in the distance to the nearest teammate, both in the offensive and defensive phases (p < .001 and p = .005, respectively). In addition, it was observed lower distance covered while running when playing in High-Sup compared to No-Sup (0.30 [-0.01; 0.61]; p = .002) during the defensive phase. Attacking in numerical inferiority promoted a higher variability in the distance to the nearest teammate from No-Inf to High-Inf (0.83 [0.27; 1.38]; p = .044), while decreasing the physical demands, specifically distance covered while running (-0.49 [-0.99; 0.01]; p = .039). In turn, defending, mainly in high-inferiority, increased the total distance covered compared to No-Inf (0.61 [0.30; 0.91]; p < .001) and led to a decrease in the distance to the nearest teammate (-0.90 [-1.35; -0.44]; p = .002). Overall, coaches may manipulate the number of teammates and opponents to promote distinct effects at the level of cooperation and opposition dynamical interactions.
Cost-effectiveness analysis of durvalumab as a maintenance treatment for patients with locally advanced, unresectable, stage Ⅲ nsclc in china

Objective The aim of this study was to evaluate the cost-effectiveness of durvalumab compared with Best supportive care (BSC) after chemoradiotherapy in patients with stage III non-small cell lung cancer from healthcare system perspective in China. Methods A dynamic state transition model was adopted to simulate life time, direct medical costs and QALYs. In the base case scenario, for patients with unresectable, stage Ⅲ non-small cell lung cancer whose disease has not progressed after platinum-based chemoradiation therapy, the treatment group would use durvalumab whereas the control group would use BSC. Clinical data and health utility were derived from the patient-level data of Asian ethnicity in the PACIFIC trial. Cost of drug acquisition, follow-up, medical service, inspection, terminal care and adverse event treatment were considered in this model. The cost of durvalumab was calculated based on retail prices and Patient Assistance Program. Results In the base case, the durvalumab group yielded an additional 2.60 LYs and 2.37QALYs (discounted), causing an additional cost of 0.459 million RMB and 0.109 million RMB without and with PAP, so the ICER was 193,898 RMB/QALY and 46,093.12 RMB/QALY respectively. Conclusions This study demonstrated that durvalumab can improve the survival of patients with unresectable, stage Ⅲ non-small cell lung cancer whose disease has not progressed after platinum-based chemoradiation therapy and would be a cost-effective option compared with BSC at a willingness to pay (WTP) threshold of 212676 RMB (three times GDP per capita of China in 2019).
Tips, tricks, and thoughts on the future of prehospital blood transfusions

Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Department of Surgery, University of Toronto, Toronto, Ontario, Canada Army Blood Program, US Army Medical Command, JBSA-FT Sam Houston, Fort Sam Houston, Texas, USA Canadian Blood Services, Ottawa, Ontario, Canada U.S. Army Institute of Surgical Research, JBSA-FT Sam Houston, Fort Sam Houston, Texas, USA Armed Services Blood Program, Defense Health Agency, Falls Church, Virginia, USA Departments of Emergency Medicine and Biomedical Engineering, Max Harry Weil Institute for Critical Care Research and Innovation, University of Michigan, Ann Arbor, Michigan, USA Department of Medicine, Uniformed Services University, Bethesda, Maryland, USA