Miracle-dz/UniFAR-FTUs huggingface dataset:
Caracterização química dos neonicotinóides em águas superficiais via cromatografia liquída de alta eficiência acoplada a espectrometria de massas em tandem (HPLC-MS/MS)

The present study aimed to develop a method for the determination and validation of a method for the identification and quantification of Neonicotinoids in surface waters collected in the Bauru region, in the state of São Paulo. The analytical techniques studied for the development of this method were the high performance liquid chromatography with tandem mass spectrometry (HPLC MS / MS), gas chromatography with mass spectrometry (GC / MS) and gas chromatography with electron capture detector (GC / ECD). The class of pesticides Neonicotinoids was chosen for this work because it is related to a sudden disappearance of bees in colonies around the world. This phenomenon is known as Colony Collapse Disorder (CCD) and it is characterized by a rapid loss in the population of adult bees. The Neonicotinoids used in this study were the compounds Clothianidin, Imidacloprid and Thiamethoxam which were banned in their use as pesticides in Europe by Implementing Regulation No. 540/2011. The samples were concentrated using solid phase extraction (SPE) and liquid liquid extraction (LLE) techniques and injected into HPLC-MS / MS, GC / MS and GC / ECD. The GC / ECD and GC / MS techniques were not satisfactory for determination in the water matrix because the detection limit (10 mg L) is above the maximum allowed by the US Environmental Protection Agency (0.6 μg L). The HPLC MS / MS technique using the multiple reaction monitoring (MRM) proved to be adequate for this study because it obtained quantification limits between 5.89 and 8.06 μg L and a linearity between 0.9963 and 0.9999 for the three compounds.
Nomophobia associated with depression, anxiety, and stress in nursing students: A cross-sectional study in college of nursing, Jeddah, Saudi Arabia

Background: Nomophobia is described as the fear of losing contact with mobile phones. It is widely reported in nursing students who may also experience depression, anxiety, and stress. Little is known about the relationship of nomophobia with depression, anxiety, and stress. Objectives: This study was designed to (a) assess nomophobia in nursing students and to (b) evaluate the impact of depression, anxiety, and stress on nomophobia in nursing students. Material and Methods: The study was carried out in College of Nursing, Jeddah, Saudi Arabia. Study sample (n = 311) comprised students enrolled in all levels of bachelor of science in Nursing degree. A self-administered survey was conducted using the Nomophobia Questionnaire tool for nomophobia and DASS-21 for depression, anxiety, and stress. Results: Undergraduate nursing students were presented with mild (12.9%), moderate (46.9%), and severe (40.2%) nomophobia. The highest mean score yielded for nomophobia Factor 1 – not being able to communicate (4.74 ± 1.77), whereas the lowest score was noted for nomophobia Factor 2 – losing connectedness (4.07 ± 1.96). A significant positive correlation was noted between depression and Factor 4 – giving up convenience of nomophobia (r = 0.11, P < 0.05). A high prevalence of nomophobia was noted. Severity of depression contributed positively to severity of nomophobia. Conclusion: Findings indicate the coexistence of depression, anxiety, or stress in nomophobia.
Description and management of retinopathy of prematurity reactivation after intravitreal antivascular endothelial growth factor therapy

Purpose of review To review the literature regarding reactivation of retinopathy of prematurity (ROP) after treatment with antivascular endothelial growth factor (anti-VEGF) agents. Recent findings Reactivation can occur after anti-VEGF or laser. Risk factors for reactivation include patient and disease-related factors. Various studies are evaluating the use of different anti-VEGF agents and reactivation rates. However, the definition of reactivation varies between studies. Summary The literature has varied definitions of reactivation, which is often used interchangeably with recurrence. It is important to recognize features of reactivation of ROP to appropriately manage patients and conduct clinical trials. The International Classification of ROP 3rd edition has established a consensus guideline regarding terminology describing reactivation.
Increased expression of Cyclin F in liver cancer predicts poor prognosis

Abstract Background: Cyclin F (CCNF) dysfunction has been implicated in various forms of cancer, offering a new avenue for understanding the pathogenic mechanisms underlying hepatocellular carcinoma (HCC). We aimed to evaluate the role of CCNF in HCC using publicly available data from The Cancer Genome Atlas (TCGA). Method: We used TCGA data and Gene Expression Omnibus (GEO) data to analyze the differential expression of CCNF between tumor and adjacent tissues and the relationship between CCNF and clinical characteristics. We compared prognosis of patients with HCC with high and low CCNF expression and constructed receiver operating characteristic (ROC) curves. In addition, we also explored the types of gene mutations in relevant groups and conducted Gene Set Enrichment Analysis (GSEA). Results: The expression of CCNF in liver cancer tissues was significantly increased compared with that in adjacent tissues, and patients with high CCNF expression had a worse prognosis than those with low CCNF expression. Patients with high CCNF expression also had more somatic mutations. High expression of CCNF hampers the prognosis independently. The GSEA showed that the "http://www.gsea-msigdb.org/gsea/msigdb/cards/BIOCARTA_WNT_PATHWAY" Wnt pathway, "http://www.gsea-msigdb.org/gsea/msigdb/cards/BIOCARTA_P53_PATHWAY" P53 pathway, "http://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PI3K_AKT_MTOR_SIGNALING" PI3K/Akt/mTOR pathway, "http://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_NOTCH_SIGNALING" Notch pathway were enriched in patients with the high CCNF expression phenotype. Conclusion: High CCNF expression can be seen as an independent risk factor for poor survival in HCC. Its expression may serve as a target for the diagnosis and treatment of liver cancer.
Lifestyle and behavioral changes during nationwide lockdown in India—A cross-sectional analysis

Introduction: After almost two months of reporting the first case of the novel coronavirus disease (COVID-19) in the country, the nationwide lockdown in India was initiated on 24th of March 2020, to curtail the spread of the SARS-CoV-2 infection in the country. While this lockdown had been in place for almost 3 months, the people of the nation have experienced changes in their routine lives in a wide range of activities, including personal behaviours. This study was conducted to identify the impacts that the lockdown had on the lifestyle and behavioural aspects of Indians during the lockdown. Methods: It was a cross sectional study, conducted by online survey. Data collection was done for the period of 3 months. Results: The study found that a huge number of participants had significant changes in their diet, sleep, bowel habits and also their personal traits. Also, the lockdown had improved interpersonal relationships and helped people explore their hobbies or even acquire a new skill (about 25% of the participants). More than 90% of the participants perceived decrease in air pollution and a majority reported increase in personal hygiene (74.2%), perceived decrease in crime rates (67.3%) as benefits of lockdown. Conclusions: It would be recommended to include variables to screen for mental health issues among the general population.
A rapid response of lung squamous cell carcinoma following treatment with sintilimab combined with recombinant humane endostatin injection and nab-paclitaxel in an elderly patient

Abstract Rationale: At present, the prognosis of patients with giant lung squamous cell carcinoma (LSCC) is poor, and there is no safe and effective treatment for elderly patients with large LSCC. Patient concerns: Here, we reported a 77-year-old man admitted to the hospital with cough for 3 months and significant chest pain. Computed tomography (CT) imaging showed a large mass in the left lung with pleural effusion. Diagnoses: Chest CT scan revealed a 12.5 cm × 7.3 cm mass in the left upper lobe adjacent to the pulmonary vein, with left pleural effusion. Pulmonary tumor markers were significantly elevated, and CT-guided percutaneous lung mass biopsy specimens showed LSCC. Interventions: After diagnosis, the patient was treated with sintilimab combined with endostar and nab-paclitaxel. After 2 cycles of treatment, the lung mass in the patient shrank rapidly and the clinical symptoms were relieved. Outcomes: The patient's tumor dramatically shrank, and the pleural effusion was decreased after 4 cycles of treatment without any adverse effects. Meanwhile, the high-level tumor marker resumed normal. Lessons: Sintilimab combined with endostar and nab-paclitaxel may be a good treatment option for lung squamous cell cancer, especially for that in elderly patients.
Effects of Chlorophytum borivilianum Sant. F against gamma radiation-induced testicular injuries in Swiss albino mice

Background: Radiation therapy is considered as an important tool in cancer treatment. Despite its impressive role in treating cancer, severe side effects in organs have been reported. To address these therapeutic side effects, several combination methods have been identified to minimize adverse effects caused by radiation therapy. Aims and Objectives: Based on higher radioactive sensitivity of testicular tissues, administration of Chlorophytum borivilianum (CB) Sant. F extracts was evaluated for its protective effects against radiation in testis. Materials and methods: Two forms of CB extracts (CB alone and CB-silver nanoparticles [AgNPs]) were administered at a dose of 50 mg/kg body weight in Swiss albino male mice for 7 consecutive days. Following 6 Gy gamma radiation, animals were observed for 30 days in four phases. Sperm counts, body weight, testicular weight and stereological and histological evaluation of testis were evaluated. Results: Following irradiation, a significant decline in body weight (P = 0.008) and testicular weight (P = 0.001) was noted when compared with control. Ununiformed type A and B spermatogonia, partially filled tubules, inter-tubular vacuoles, and disrupted epithelium were the main types of damages caused by irradiation. Reorganization and resumption of histological features emerged from the 15th day postirradiation in CB extract (CBE)-treated animals. Conclusion: Testicular response was observed against radiation in animals treated with CB extracts, while CB-AgNPs indicated better toleration when compared to CB extract alone.
Stress fluctuations and elasticity in one- and two-component cubic crystals

ABSTRACT The elastic constants of the Lennard-Jones system and a binary repulsive particle system (in 1:13 composition) obeying the Weeks-Chandler-Andersen (WCA) potential (WCA2-AB13 system) have been computed using the stress fluctuation formalism by equilibrium molecular dynamics simulations. The systems are under finite fixed pressures. The evolution of the elastic moduli as a function of the temperature is characterised. In both systems, the melting transition is signalled by a jump of the shear modulus, in consistence with the behaviour of the specific volume. At zero temperature, while the elasticity is totally affine for the Lennard-Jones face-centered cubic (fcc) crystal, it clearly contains a non-affine part for the AB13 cubic superlattice. The evolution of the non-affine elasticity as a function of the temperature is investigated, and its behaviour is compared to that of a typical glass-former.
Prohibitin gene regulation in cancer and its possible therapeutic potential

Prohibitin (PHB), an evolutionary conserved gene, is mapped at the chromosomal location 17q21–q22 and is present with two isoforms, namely, PHB1 and PHB2. Both of these isoforms have their individual roles in tumor suppression and cell proliferation. The presence of these isoforms is not restricted to single cellular organelle but can be located in the nucleus, mitochondria, and cytosol. Importantly, loss of heterozygosity in the prohibitin gene has been noted in a significant number of different cancer types. Along with this, there are other mutations that contribute to tumorigenesis and cancer cell proliferation. Sporadic breast cancer, lung cancer, and prostate cancer are a few examples in which regulation of PHB plays a major role. PHB has shown to be both up-regulated and down-regulated depending on the type of cancer or disease. PHB acts as the biomarker for several types of cancers and is also seen as a potential therapeutic target. Along with cancer, PHB has also been seen to play an important role in other diseases such as neurological diseases, cardiac diseases, and renal diseases. The link between PHB and a plethora of diseases opens a new window in which PHB can be actually targeted in treatment as well as disease management. Here, we review the regulation of PHB in different types of cancers along with its significant interaction in other disorders.
An Authentication Mechanism for Autonomous Vehicle ECU Utilizing a Novel Slice-Based PUF Design

: Modern autonomous vehicles are getting progressively popular and increasingly getting closer to the core of future development in transportation field. However, there is no reliable authentication mechanism for the unmanned vehicle communication system, this phenomenon draws attention about the security of autonomous vehicles of people in all aspects. Physical Unclonable Function (PUF) circuits is light-weight, and it can product unique and unpredictable digital signature utilizing the manufacturing variations occur in each die and these exact silicon features cannot be recreated theoretically. Considering security issues of communication between Electronic Control Units (ECUs) in vehicles, we propose a novel delay-based PUF circuit using all the available logical components in every two-slice within Configurable Logic Blocks (CLBs) in Field Programmable Gate Array (FPGA) chips, which is significantly suitable for circuit authentication in ECUs of autonomous vehicles and is a significant improvement over the usual arbiter PUF in resource occupation in FPGA chips, that is to say it can get stronger resistance to security risks with less logic resource overhead. Our PUF design is resource efficient so that it can exactly be applied to the source-constrained devices such as in-vehicle ECUs. It effectively reduce the risk of the messages delivered between ECUs being tampered and then vehicle be illegally controlled by adversary. We simulated the proposed PUF circuit in simulator and implemented it on Xilinx boards under different conditions to obtain experimental results, the analyzed result proves that the proposed PUF satisfies the properties of Uniqueness and Stability. Finally, the ECUs authentication mechanism utilizing our PUF circuit is introduced.
IoT Based Monitoring and Speed Control of an Induction Motor

Today's IoT plays an essential role in our day to day life. This paper thesis deals with the hardware part for monitoring the continuous parameters and speed control part of Induction Motor. In that monitored parameters with the help of sensors is a voltage sensor, current sensor, speed sensor, and temperature sensor. And by controlling the speed part of the induction motor with the help of PWM techniques. By monitoring the parameters of the induction motor, it should help to maintain the before any fault occurs and prevent delay in production, which is the reliability of the induction motor obtained. If there is any fault takes place in the induction motor should be automatically disconnected from the supply by using IoT applications. Also analysis the results in graphical form. simulation perform on Proteus software regarding parameter monitoring And speed control of an induction motor.
N-ary Information Markets: Money, Attention, and Personal Data as Means of Payment

On information markets, we can identify different relations between sellers and their customers, with some users paying with money, some paying with attention, and others paying with their personal data. For the description of these different market relations, this article introduces the notion of arity into the scientific discussion. On unary information markets, customers pay with their money; examples include commercial information suppliers. Binary information markets are characterized by one market side paying with attention (e.g., on the search engine Google) or with personal data (e.g., on most social media services) and the other market side (mainly advertisers) paying with money. Our example of a ternary market is a social media market with the additional market side of influencers. If customers buy on unary markets, they know what to pay (in terms of money). If they pay with attention or with their personal data, they do not know what they have to pay exactly in the end. On n-ary markets (n greater than 1), laws should regulate company’s abuse of money and ― which is new ― abuse of data streams with the aid of competition (or anti-trust) laws, and by modified data protection laws, which are guided by fair use of end users’ attention and data.
Braided Polyester versus Standard Wire in Sternal Closure in High Risk Patients

Objective: The aim of this study was to compare braided polyester sternal closure versus standard wire closure in high-risk patients who are more susceptible to have deep sternal wound infections and mediastinitis after cardiac surgeries. Patients and Methods: Between February 2017 and December 2019 risk factors for postoperative deep wound infections and mediastinitis and mortality was collected for 100 adult patients undergoing open-heart surgery under cardiopulmonary bypass. Patients were divided to two groups, those who underwent sternal closure using either braided polyester or standard metal wire. Follow-up data on sternal wound healing and deep sternal wound infections were assessed for up to two months after surgery in the Outpatient Clinics. Results: The followingriskfactors wereassociatedwithahigherincidenceofdeepsternalwoundinfectionsandmediastinitis in both groups. There was no mortality in both groups, the number of deep sternal infection and mediastinitis with sternal dehiscence was 4 patients from group A (Ethibond) and 5 from group B (standard wire). Conclusion: This study showed that braided polyester could be used safely in sternal closure the same as standard wire in high risk patients.
METABOLIC ENGINEERING OF MEP PATHWAY FOR OVERPRODUCTION OF LYCOPENE IN SACCHAROMYCES CEREVISIAE USING PESC-LEU AND PTEF1/ZEO VECTORS

Recent studies indicated that overexpression of dxs and idi genes in bacteria transformed with crtEBI genes dramatically improved the production of lycopene. The aim of the present study was the assessment of crtEBI-transformed S. cerevisiae overexpressing the bacterial synthetic dxs and yeast idi genes for lycopene production. The two genes were driven by galactose-induced promoters namely GAL1 and GAL10, respectively, of the pESC-LEU yeast vector of which gene cassettes were inserted in pTEF1/Zeo vector. The synthetic dxs gene was constructed in accordance with the preferred codon usage in S. cerevisiae with no change in the resulting amino acid sequences. The RT-PCR analysis indicated that the two genes were efficiently transcribed in crtEBI-transformed S. cerevisiae cells. The highest production of lycopene (6755 μg lycopene/g dry cell weight) was reached for yeast cells transformed with the two genes, which is higher than the previously reported lycopene levels in yeast. The level of AcetylCoenzyme A (Acetyl-CoA) was negatively related to that of lycopene in transformed S. cerevisiae cells, suggesting that lycopene and Acetyl-CoA biosyntheses compete for the use of pyruvate.
Isolation of Phenylacetic Acid and Its p-Hydroxy Derivative as Auxin-like Substances from Undaria pinnatifida

During the course of our studies on plant growth regulators in marine algae, we have recently isolated indoleacetic acid (IAA) as an auxin and indolecarboxylic acid (ICA) as an auxin-related substance. " In a further investigation, we found that acidic substances other than IAA still promote the growth of Avena coleoptile sections. In this communi cation, we describe the isolation and identifica tion of active principles from U. pinnatifida. The strong acidic fraction remaining after the isolation of IAA and ICA was subjected to adsorption column chromatography on silicic acid using mixed solvents with an nhexane-ethyl acetate system. When this chromatography was repeated twice, two ac tive acids (substance I and II) were eluted with n-hexane containing 15% and 40 ethyl acetate, respectively. These were further purified by Sephadex LH-20 gel filtration to give colorless plates. The yields and characterizations of sub stances I and II obtained from 118 kg of algae are as follows. I: 62 mg, mp 78 79°C, UV 2,m,' ": 247, 252, 258, 264, 267 (sh), IR vKBrmaxcm-1: 695 (carbonyl), 1600, 1500, 750 (aromatic ring). The NMR spectrum in deuteriochloroform showed a monosubsti tuted phenyl signal at 87.30 (5H, s) and a me thylene signal at 53.66 (2H, s). Thus, I was assigned as phenylacetic acid (PAA); II: 14 mg, mp 151-153°C, UV 2 'I ' (s): 278 (1930), 283 (sh, 1650), vKBrmaxcm-1: 3300 (hydroxyl), 1700 (carbonyl), 1600, 1515, 795 (aromatic ring). In the NMR spectrum in deuterioacetone, the coupling constant of signals at 66.77 (2H, d, J=8.7 Hz) and 57.14 (2H, d, J=8.7 Hz) indicated the presence of a p-substituted aromatic ring, and a signal at 83.49 (2H, s) was assigned to a methylene group. Thus, II was confirmed to be phydroxyphenylacetic acid (p-OH-PAA). Furthermore, the IR, UV, NMR spectra, the melting points and Rf values on a paper chro matogram were completely identical with those of authentic specimens. In paper chromatography using isopropanol ammonia-water (10: 1: 1, v/v) as an ascending solvent, the Rf values of PAA and p-OH-PAA were 0.60 and 0.39, respectively, being adjacent to IAA zone at 0.47. The results of biological activity tests with
An Evaluation of a Royalty Relief Model for Mature Fields; #90017 (2003)

This paper presents a an evaluation of a deterministic model for royalty relief using a combination of different types of decline curves, operational costs, and prices of several oil types. The paper also provides an analysis of its impact in the cash flow of the project and in tax collection. The model allows obtaining a balance between profitability and fiscal demands of projects under a royalty and tax (R&T) fiscal framework. In the proposed model, the simulation of financial variables for mature fields with reserves within a range of 500 thousand to 2 million barrels, indicates competitive results considering the amount of investments and the inherent risks of the project.