Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of α 3 GlyR single particle tracking in the cell membrane

diffusion.Athoroughinterpretationofthedisplacementsrequiresanextensiveanalysissuitedfordiscrimination ofdifferent motiontypespresent inthedata.Herethe diffusionpattern of thehomomeric α 3-containingglycine receptor (GlyR)isanalyzedinthemembraneofHEK 293 cells.Morespeci ﬁ cally,thein ﬂ uenceof the α 3 RNA splicevariants α 3Kand α 3L on lateralmembranediffusion of the receptoris revealedin detail.Using acom-bination of ensemble and local SPT analysis, free and anomalous diffusion parameters are determined. The GlyR α 3 free diffusion coef ﬁ cient is found to be 0.13 ± 0.01 μ m 2 /s and both receptor variants display con-ﬁ ned motion. The con ﬁ nement probability level and residence time are signi ﬁ cantly elevated for the α 3L variant compared to the α 3K variant. Furthermore, for the α 3L GlyR, the presence of directed motion was also established, with a velocity matching that of saltatory vesicular transport. These ﬁ ndings reveal that α 3 GlyRs are prone to different types of anomalous diffusion and reinforce the role of RNA splicing in determining lateral membrane traf ﬁ cking.
THE RELATIONSHIP BETWEEN FOREIGN DIRECT INVESTMENT AND CAPITAL FLIGHT IN NIGERIA

In this study, we empirically explore the interactions between foreign direct investment (FDI) and capital flight in Nigeria. Essentially, theory has it that capital flight is detrimental to economic growth while FDI promotes development in any economy. Owing on this facts, over the years, Nigeria has allowed tremendous increase in FDI flows but unfortunately it effects has not materialized on economic growth despite great availability of natural resources and large market size because capital flight (with it attendant negating impact) has also increased simultaneously. With seeming evidence of symbiotic interactions between them, we cannot conclude on mere observations but utilized the simultaneous equation approach in econometric to quantitatively examine the relationship between them. In particular, generalized instrumental variable estimation and the Cochrane Orcutt Method (to correct serial correlation) were adopted following the review of relevant literature. The finding was that there is a significant positive relationship between FDI flows and capital flight in Nigeria for the periods studied. This finding was justifiable because all measures of capital flight incorporate FDI as one component of its estimation.
Sliding Behavior of Friction Material Against Cermet Coatings: Pin-on-Disc Study of the Running-in Stage

Running–in is the initial stage during which a tribological system reaches a steady state condition. In this study, the running-in behavior of a commercial brake friction material, pin-on-disc tested under dry sliding conditions has been investigated to understand the role of different surface finishing of hard coatings. These coatings were deposited onto the cast iron counterface disc and then mechanically polished to achieve set values of average roughness, R a , and roughness skewness, R sk . The tribological data were modeled using an exponential relation for the wear rate, according to a literature approach. The model parameters were related to the above disc surface roughness parameters. The results were interpreted in terms of the main wear mechanisms, that determine the formation of the friction layers on the pins as well as discs wear tracks. Of particular relevance is the finding that a negatively-skewed surface roughness is fundamental to achieve the best running-in performances. The beneficial effects coming from this surface treatment derive from the reduction in abrasion and from improved dynamics in the formation of the friction layer, with particular regard to those parts (secondary plateaus) made of compacted wear debris.
Influencing Factors for the Adoption of Speech Assistance in Influencing Factors for the Adoption of Speech Assistance in Manufacturing Manufacturing

In recent years, there has been a steady increase in the use of speech assistants in the private environment. Although such assistance systems would also be beneficial for manufacturing (for example, because workers have their hands free), speech assistants have not yet been widely used in the industrial environment. Against this background, we develop in this article a model with factors that influence the decision of industrial firms whether to adopt speech assistance for manufacturing. In order to do so, we rely on the Technology-Organiza-tion-Environment (TOE) framework and by interviewing 10 experts from firms that develop or use speech assistance solutions. Our model consists of 17 context factors that influence whether companies adopt speech assistance in manufacturing.
METTL21C mediates the occurrence of autophagy and formation of slow-twitch muscle fibers after exercise.

Homeostasis is essential for muscle repair and regeneration after skeletal muscle exercise. This study investigated the role of methyltransferase-like 21C (METTL21C) in skeletal muscle of mice after exercise and the potential mechanism. First, muscle samples were collected at 2, 4, and 6 weeks after exercise, liver glycogen, muscle glycogen, blood lactic acid (BLA) and triglyceride (TG) were assessed. Moreover, the expression levels of autophagy markers and METTL21C in skeletal muscle were analyzed. The results showed that the expressions of METTL21C and MYH7 in the gastrocnemius muscle of mice in the exercise group were significantly higher than that in the control group after exercise, which suggested that long-term exercise promoted the formation of slow-twitch muscle fibers in mouse skeletal muscle. Likewise, the autophagy capacity is enhanced with the extension of exercise in muscles. The findings were further verified in mouse C2C12 cells. We discovered that knockdown of Mettl21c reduced the expression of MYH7 and autophagy level in mouse myoblasts. These findings indicate that METTL21C promotes skeletal muscle homeostasis after exercise by enhancing autophagy, while METTL21C also contributes to differentiation of myogenic and formation of slow muscle fiber.
Robust Perceptual Hashing as Classification Problem: Decision-theoretic and Practical Considerations

— In this paper we consider the problem of robust perceptual hashing as composite hypothesis testing. First, we formulate this problem as multiple hypothesis testing under prior ambiguity about source statistics and channel parameters representing a family of restricted geometric attacks. We introduce an efficient universal test that achieves the performance of informed decision rules for the specified class of source and geometric channel models. Finally, we consider the practical hash construction, which compromises computational complexity, robustness to geometrical transformations, lack of priors about source statistics and security requirements. The proposed hash is based on a binary hypothesis testing for randomly or semantically selected blocks or regions in sequences or images. We present the results of experimental validation of the developed concept that justifies the practical efficiency of the elaborated framework.
Humoral immune responses in different stages of wound healing in Black Bengal goats

Objective: The current study was carried out to assess the humoral immune responses according to age at different stages of wound healing in Black Bengal goats (BBG). Materials and Methods: Apparently, healthy BBGs (n = 20) were collected and divided into five groups based on their age: Group A (control, 3 years), Group B (3 to 5 years), Group C (2 to <3 years), Group D (1 to <2 years), and Group E (<1 year). Except for control, all BBGs were allowed to have artificial surgical wounds, and follow-up data were collected from day 0 to 21. The humoral immune responses [immunoglobulins (Igs) and interleukin-6 (IL-6)] were determined by ELISA using commercial goat ELISA kits. Statistical Product and Service Solutions (Version 20) was used to analyze the data. Results: The normal range of immune cells in control BBGs was immunoglobulin G (IgG) (20.21 ± 0.13 mg/ml), immunoglobulin M (IgM) (2.87 ± 0.0.05 mg/ml), immunoglobulin A (IgA) (0.33 ± 0.01 mg/ml), and IL-6 (1.6 ± 0.05 pg/ml). In this experiment, higher concentrations of IgG (21.11 ± 0.20 mg/ml), IgM (2.92 ± 0.04 mg/ml), IgA (0.35 ± 0.02 mg/ml), and IL-6 (1.62 ± 0.05 pg/ml) were found in Group B BBGs, whereas the lower levels of IgG, IgM, IgA, and IL-6 were found at 17.16 ± 0.18 mg/ml, 2.12 ± 0.01 mg/ml, 0.29 ± 0.03 mg/ml, and 1.55 ± 0.05 pg/ml, respectively, in the Group E BBGs. Rapid wound healing was observed in the older groups compared to the younger groups of BBGs. The concentrations of Igs (IgG, IgM, and IgA) and IL-6 were gradually increased in all groups from day 3 (early inflammatory stage) and day 7 (late inflammatory stage), and then they decreased gradually from day 14 (proliferative stage) to reach the final stage of day 21 (remodeling stage), where the concentrations were found to be at a level comparable to their per-incisional period. No gender-related differences were detected. Conclusion: Adult BBGs (3 to 5 years old) showed faster wound repair and stronger immune responses. This finding may assist veterinarians and researchers in considering age-related immune responses for the recovery and rapid cure of surgical wounds.
Measurement of dijet k T in p–Pb collisions at

A measurement of dijet correlations in p–Pb collisions at √ s NN = 5 . 02 TeV with the ALICE detector is presented. Jets are reconstructed from charged particles measured in the central tracking detectors and neutral energy deposited in the electromagnetic calorimeter. The transverse momentum of the full jet (clustered from charged and neutral constituents) and charged jet (clustered from charged particles only) is corrected event-by-event for the contribution of the underlying event, while corrections for underlying event ﬂuctuations and ﬁnite detector resolution are applied on an inclusive basis. A projection of the dijet transverse momentum, k Ty = p ch + ne T , jet sin ((cid:3) ϕ dijet ) with (cid:3) ϕ dijet the azimuthal angle between a full and charged jet and p ch + ne T , jet the transverse momentum of the full jet, is used to study nuclear matter effects in p–Pb collisions. This observable is sensitive to the acoplanarity of dijet production and its potential modiﬁcation in p–Pb collisions with respect to pp collisions. Measurements of the dijet k Ty as a function of the transverse momentum of the full and recoil charged jet, and the event multiplicity are presented. No signiﬁcant modiﬁcation of k Ty due to nuclear matter effects in p–Pb collisions with respect to the event multiplicity or a PYTHIA8 reference is observed. © 2015 CERN for the beneﬁt of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Funded by SCOAP 3 .
Predictability of marine heatwaves: assessment based on the ECMWF seasonal forecast system

Abstract. Marine heatwaves (MHWs), defined as prolonged period of extremely warm sea surface temperature (SST), have been receiving a lot of attention in the past decade as their frequency and intensity increase in a warming climate. This paper investigates the extent to which the seasonal occurrence and duration of MHWs can be predicted with the European Centre for Medium-Range Weather Forecast (ECMWF) operational seasonal forecast system. The prediction of the occurrence of MHW events, the number of MHW days per season, and their intensity and spatial extent are derived from seasonal SST forecasts and evaluated against an observation-based SST analysis using both deterministic and probabilistic metrics over the 1982–2021 period. Forecast scores show useful skill in predicting the occurrence of MHWs globally for the two seasons following the starting date. The skill is the highest in the El Niño region, the Caribbean, the wider tropics, the north-eastern extra-tropical Pacific, and southwest of the extra-tropical basins. The skill is not as good for other midlatitude eastern basins nor for the Mediterranean, with the forecast system being able to represent the low-frequency modulation of MHWs but showing poor skill in predicting the interannual variability of the MHW characteristics. Linear trend analysis shows an increase in MHW occurrence at a global scale, which the forecasts capture well.
Deep cervical lymph nodes of patients with multiple sclerosis show dysregulated B cells in the presence of Epstein-Barr virus

Despite the recognized role of Epstein-Barr virus (EBV) in predisposing to multiple sclerosis (MS) and the effectiveness of B cell-depleting therapies in MS, the mechanism of autoimmunity remains elusive. Using fine needle aspirations, we investigated deep cervical lymph nodes (dcLNs), the primary site of the adaptive immune response against EBV, in newly diagnosed untreated MS patients and healthy controls. We characterized the immune landscape of dcLNs with scRNAseq and CITE-seq and observed increased memory B cell proportions and reduced germinal center (GC) B cells with decreased clonality in patients with MS compared to healthy controls. In the patient with an active MS relapse, we detected elevated plasmablasts, reduced GC B cells, and clonally expanded memory CD8 T cells targeting EBV in the dcLN. These findings, along with increased EBV DNA detection in dcLNs and viral loads in patient saliva, support B cell dysregulation as a key mechanism in MS pathogenesis.
A Pilot Study of a Ketogenic Diet in Bipolar Disorder: Clinical, Metabolomic and Magnetic Resonance Spectroscopy Outcomes

Background Bipolar disorder and epilepsy are treated with anti-seizure medications. Preliminary evidence indicates that a ketogenic diet (a metabolic treatment for epilepsy) may be effective in the treatment of bipolar disorder. Aims To explore the impact of a ketogenic diet on clinical outcomes, and metabolomic and brain magnetic resonance spectroscopy biomarkers. Methods Euthymic individuals with bipolar disorder (N=27) were recruited to a 6-8 week single-arm trial of a modified ketogenic diet and a range of metabolic and clinical outcome measures were assessed. Results There was a positive correlation between daily ketone levels and ecological momentary assessments of mood (p < 0.001) and energy (p < 0.001) and an inverse correlation between ketone levels and impulsivity (p < 0.001) and anxiety (p < 0.001). Mean weight fell by 4.2kg (p < 0.001), mean BMI fell by 5.3% (p < 0.001) and mean systolic blood pressure was reduced by 7.4 mmHg (p < 0.041). Brain Glx (a putative marker of treatment response to anti-seizure medication) decreased by 13.1% in the posterior cingulate cortex (PCC) (p < 0.001) and by 9.2% in the anterior cingulate cortex ACC (p = 0.02). At the dietary cessation period, one third of participants, who reported reduced mood lability, opted to remain on a ketogenic diet. Conclusion The majority of participants had improved cardiometabolic risk parameters and approximately one third experienced improvement in psychiatric symptoms. The study findings are consistent with our a priori hypothesis of ketone bodies acting as an alternative metabolic substrate under conditions of impaired insulin signalling in a subgroup of patients with bipolar disorder.
Household characteristics associated with environmentally persistent free radicals in house dust in two Australian locations

The association between air pollution and adverse health outcomes has been extensively studied, and while oxidative stress in likely to be involved, the underlying mechanism(s) remain unclear. Recent studies propose environmentally persistent free radicals (EPFRs) as the missing connection between air pollution and detrimental health impacts. However, the indoor environment is rarely considered in EPFR research. We measured EPFRs in household dust from two locations in Australia and investigated household characteristics associated with EPFRs. Random forest models were built to identify important household characteristics through variable importance plots and the associations were analysed using Spearmans rho test. We found that age of house, type of garage, house outer wall material, heating method used in home, frequency of extractor fan use when cooking, traffic related air pollution, frequency of cleaning and major house renovation were important household characteristics associated with EPFRs in Australian homes. The direction of association between household characteristics and EPFRs differ between the locations. Hence, further research is warranted to determine the generalisability of our results.
Holocene Palaeofloods Recorded in the East Xunyang Reach in the Upper Hanjiang River

Integrative studies of palaeoflood hydrology were carried out in the upper reaches of the Hanjiang River,a major tributary of the Yangtze River.Two sets of palaeoflood slackwater deposits were found in the east Xunyang reach.The very typical flood slackwater deposits were identified in the slope clastic deposit profile.The NGK site in the bedrock gorges was chosen for palaeo-hydrology study.On the basis of field survey,sediment samples were taken for analyzing grain size distribution and magnetic susceptibility.The results of field observation and grain-size and magnetic susceptibility indicate that these slackwater deposits are very typical and that they have been deposited by suspended sediment load in the floodwater of the Hanjiang River.Stratigraphic correlation with ETC profile of Jinghe River basin and JJTZ profile downstream of the NGK site shows that the palaeoflood events occurred at 9000-8500 a BP and 3200-2800 a BP respectively.The flood peak discharges were reconstructed to be 45630-50220 m3/s.Reconstruction of modern flood(2010.07.18) and comparison with the gauged discharge proved the hydrological method used and its results were reliable.And the relationship between drainage area and flood peak discharge illustrated that the reconstructed discharges were reasonable.A relationship between peak discharge and occurrence frequency at 10000-year time-scale was established.This result is very important for flood design in the hydraulic engineering,soil and water conservation and flood control,and for understanding the response of fluvial systems to global climate change.
FusionPDB: a knowledgebase of human fusion proteins

Abstract Tumorigenic functions due to the formation of fusion genes have been targeted for cancer therapeutics (i.e. kinase inhibitors). However, many fusion proteins involved in various cellular processes have not been studied for targeted therapeutics. This is because the lack of complete fusion protein sequences and their whole 3D structures has made it challenging to develop new therapeutic strategies. To fill these critical gaps, we developed a computational pipeline and a resource of human fusion proteins named FusionPDB, available at https://compbio.uth. edu/FusionPDB. FusionPDB is organized into four levels: 43K fusion protein sequences (14.7K in-frame fusion genes, Level 1), over 2300 + 1267 fusion protein 3D structures (from 2300 recurrent and 266 manually curated in-frame fusion genes, Level 2), pLDDT score analysis for the 1267 fusion proteins from 266 manually curated fusion genes (Level 3), and virtual screening outcomes for 68 selected fusion proteins from 266 manually curated fusion genes (Level 4). FusionPDB is the only resource providing whole 3D structures of fusion proteins and comprehensive knowledge of human fusion proteins. It will be regularly updated until it covers all human fusion proteins in the future.
Pharmacological management of connective tissue disease-associated pulmonary arterial hypertension

ABSTRACT Introduction Pulmonary arterial hypertension (PAH) is a severe, progressive pulmonary vasculopathy (Group 1 Pulmonary Hypertension (PH)) that complicates the course of many connective tissue diseases (CTD). Detailed testing is required to differentiate PAH from other types of PH caused by CTD such as left heart disease (Group 2 PH), pulmonary parenchymal disease (Group 3 PH), and chronic thromboembolic pulmonary hypertension (Group 4 PH). PAH is most frequently seen in systemic sclerosis but can also be seen with systemic lupus erythematosus, mixed CTD, and primary Sjogren’s syndrome. Areas covered This review discusses the epidemiology of CTD-associated PAH, outlines the complex diagnosis approach, and finishes with an in-depth discussion on the current treatment paradigm. Focus is placed on challenges faced in the treatment of CTD-associated PAH, (decreased efficacy and poorer tolerance of pharmacological therapies) and includes a discussion on the future investigational treatments. Expert opinion Despite significant advances over the past decades with more aggressive treatment algorithms, CTD-associated PAH patients continue to have poorer survival compared to those with idiopathic PAH. This review highlights factors leading to disparate outcomes compared to other forms of PAH, and discusses on further improvements that may increase quality of life and survival for CTD-associated PAH patients.
An index method of estimating relative population densities of the Common Vole (Microtus arvalis ) at landscape scale

De nombreuses questions d'ecologie fondamentale ou appliquee imposent l'application de protocoles d'echantillonnage a des echelles sectorielles, voire regionales, auxquelles se realisent de nombreux mecanismes ecologiques mportants. L'absence de methodes d'echantillonnage utilisables a ces echelles represente un obstacle majeur a l'analyse et a la comprehension de ces mecanismes, Pour une population de Campagnols des champs (Microlus aryalis) nous avons teste la validite d'une methode d'estimation indiciaire en densite relative applicable le long de transect, plurikilometriques. Les resultats obtenus montrent que cette methode d'estimation indiciaire en densite relative est bien adaptee au suivi des variations d'abondance et de distribution des populations du Campagnol des champs et autorise des etudes pour une grande diversite d'objectifs et d'echelles spatiales.
Role and mechanism of PVN–sympathetic–adipose circuit in depression and insulin resistance induced by chronic stress

Chronic stress induces depression and insulin resistance, between which there is a bidirectional relationship. However, the mechanisms underlying this comorbidity remain unclear. White adipose tissue (WAT), innervated by sympathetic nerves, serves as a central node in the interorgan crosstalk through adipokines. Abnormal secretion of adipokines is involved in mood disorders and metabolic morbidities. We describe here a brain–sympathetic nerve–adipose circuit originating in the hypothalamic paraventricular nucleus (PVN) with a role in depression and insulin resistance induced by chronic stress. PVN neurons are labelled after inoculation of pseudorabies virus (PRV) into WAT and are activated under restraint stress. Chemogenetic manipulations suggest a role for the PVN in depression and insulin resistance. Chronic stress increases the sympathetic innervation of WAT and downregulates several antidepressant and insulin‐sensitizing adipokines, including leptin, adiponectin, Angptl4 and Sfrp5. Chronic activation of the PVN has similar effects. β‐adrenergic receptors translate sympathetic tone into an adipose response, inducing downregulation of those adipokines and depressive‐like behaviours and insulin resistance. We finally show that AP‐1 has a role in the regulation of adipokine expression under chronic stress.