Miracle-dz/UniFAR-FTUs huggingface dataset:
Comprehensive Analysis Reveals Promising Immune Target and Prognostic Value of PLK3 in Glioma

Background PLK3, a gene played an important role in cell cycle progression and stress response, was identified in different carcinomas. However, the PLK3 expression, molecular characteristics, and prognostic value in glioma still remained unknown. Methods Total 2265 glioma samples from the CGGA RNA-seq, TCGA RNA-seq, CGGA microarray, GSE16011, as well as their clinical information and genomic profiles were selected in our research. Survival analysis based on Kaplan–Meier and Cox proportional hazard model methods was performed to evaluate the prognostic value. Results Expression of PLK3 was compared in different WHO grade, isocitrate dehydrogenase (IDH) status, and molecular subtype of gliomas. We found that increased level of PLK3 was associated with malignancy and invasiveness of glioma, and high expression of PLK3 may represent malignant entities with amplification of driver oncogenes and deletion of suppressor genes. Moreover, PLK3 played a crucial role in inflammatory and immune response, and was involved in suppressive T cell anti-tumor functions. Furthermore, PLK3 was synergistic with other checkpoint members in glioma. Finally, high expression of PLK3 was associated with malignant process and reduced survival in patients with glioma. Conclusion PLK3 may serve as an indicator of poor prognosis in glioma and a potential target for immunotherapy of glioma. These results demonstrated that PLK3 may serve as a biomarker and a potential target of glioma.
Differentiated Input and Frequency-Constant PWM Signal Generation Scheme Based on Novel Schmitt Trigger

This article presents a novel Schmitt trigger that can originate PWM signal arising from differentiation of modulating input signal in the provided time. The outstanding feature of the proposed scheme is that the PWM output has frequency-constant which does not depend on amplitude of modulating signal. That makes it suitable to use in application of adjacent frequency between carrier and modulating signal, which differs from the conventional PWM signal generators. Furthermore, the proposed circuit has relatively simpler scheme. It consists of merely 3 OTAs, 2 resistors and 1 grounded capacitor, thus it is suitable for both circuit implementation and IC realization. The experimental results are shown which is in correspondence to theoretical anticipation.
Best Practices for Integrating the Concurrent Engineering Environment into Multipartner Project Management

The use of the Internet, e-mail, and other technologies has been steadily filtering into the building process, creating a concurrent engineering (CE) environment, and enabling collaborative efforts in the building process. The concurrent engineering environment is established by a variety of tools, including internet accessible servers, e-mail, mobile telephones, and many other existing CE tools. Organizations involved in the construction process recognize the need for assessment of benefits resulting from CE tools, but find the evaluation of these benefits difficult and complicated. The project presented in this paper, “project management and organization in the concurrent engineering environment (ProCE),” is applicable to both researchers and practitioners. The ProCE project developed a measuring model, which may be used by future researchers in this area, attempted to measure benefits derived from using the CE environment in construction design and project management routines, and developed guidelines .
The effects of control techniques on the transient response of switching DC-DC converters

In the present paper, the effects of various control techniques on the transient response of a switching power supply have been discussed and compared. To improve the transient response of switching power supply presented by fast load changes, double voltage loop control technique is given. The analysis and simulation results show that double voltage loop control technique has much faster load transient response compared with conventional voltage mode and current mode control techniques.
IGBT characterisation for their protection by fuses

The case of a power IGBT can be severely damaged by high fault currents. Fast fuses can eliminate this problem. Studies and tests show that a specially designed fuse can prevent an IGBT from exploding and keep the circuit inductance below acceptable values. A thermal model is proposed in order to see how an IGBT behaves thermally during short circuits and thus to select the appropriate fuse. <<ETX>>
Factors Influence the Use of E-Promotion Means in Jordanian Business Organization

This study will examine the encouraging and discouraging factors for the use of promotion means. In order to reach the objectives of this study, a model has been developed that includes many dimensions for the encouraging and discouraging factors: e-promotion means, perceived usefulness and acceptable use of epromotion means.The factors have been identified, according to the initial survey which included (36) different organizations. The percentage of those who use the e-promotion media for their products was 69%, while 31% are still using the traditional promotion means. The five dimensions included in the study's model had five corresponding hypotheses and with each dimension having a traditional hypotheses. In addition to these five hypotheses, there were another two hypotheses; one which includes knowing the correlation between the components of the study's model and the last hypothesis concerning knowing if there are any differences between the three business organizations in the study sample (service, industrial, commerce). Thus, the seven hypotheses have been developed for this study. In order to collect the required data to examine the hypotheses and reach a conclusion, a questionnaire consisting of (22) questions covering the dimension and hypotheses of the study were applied. The design and development of this questionnaire are based on an initial pretested survey distributed to the organization. The information was collected from a sample of (212) global business organizations (service, industrial, commerce) in Jordan – Amman , all hypotheses have been proven except the seventh hypothesis which indicates minor differences between the views of the organizations on the usage of e-promotion media and at the same time there is a correlation relationship with moral indicative between the different components of the study's model.
Recurrence Analysis of Hydrologic Droughts of Differing Severity

Droughts are stochastic in nature, therefore, statistical assessment of droughts is an attractive approach for water resources planning and management. In this study, a methodology of frequency and risk analysis of hydrologic droughts, defined as an event during which the streamflow is continuously below a certain truncation level, is formulated. The theoretical derivation of the recurrence interval of hydrologic droughts with a certain severity or greater is obtained based on the concept of stochastic processes. For risk analysis, the distribution of the number of droughts occurring within a specific period of time and the distribution of the interarrival time of hydrologic droughts with a certain severity or greater are determined. To illustrate the feasibility of the proposed methodology, a recorded reservoir inflow is used as a case study. Satisfactory agreement is found between the observed data and the results of the proposed models.
Blood Vessel Strain Imaging Using Linear Array Transducer

The intrasvascular ultrasound (IVUS) imaging technique is used to diagnose cerebrovascular diseases such as stroke. Recently, elasticity imaging methods have been investigated to diagnose blood clots attached to blood vessel intima. However, the IVUS imaging technique is an invasive method that requires a transducer to be inserted into blood vessel. In this paper, strain images are obtained of blood clots attached to blood vessel intima with data acquired from outside the blood vessel using a linear array transducer. In order to measure the displacement of blood vessel accurately, experimental data are acquired by steering ultrasound beams so that they can intersect the blood vessel wall at right angles. The acquired rf data are demodulated to the baseband. The resulting complex baseband signals are then processed by an autocorrelation algorithm to compute the blood vessel movement and thereby produce strain image. This proposed method is verified by experiments on a plastic blood vessel mimicking phantom. The efficacy of the proposed method was verified using a home-made blood vessel mimicking phantom. The blood vessel mimicking phantom was constructed by making a 6 mm diameter hollow cylinder inside it to simulate a blood vessel and adhering 2 mm thick soft plaque to the inner wall of the hollow cylinder. The RF data were acquired using a clinical ultrasound scanner (Accuvix XQ, Medison, Seoul. Korea) with a 7.5 MHz linear array transducer by steering ultrasound beams in steps of 1 o from -40 o to 40 o for a total of 81 angles. Experimental results show that the plaque region near the blood vessel wall is softer than background tissue. Although the imaging region is restricted due to the limited range of angles for which scan lines are perpendicular to the wall, the feasibility of strain imaging is demonstrated.
Anisotropic Actuation with Piezoelectric Fiber Composites

An investigation was made into the field of planar structural actuation with anisotropic active materials. The mechanisms for creating anisotropic actuators were discussed, and the impact of anisotropy was shown at the individual lamina level and at the laminated structure level. Models for laminated structures were developed using an augmented Classical Laminated Plate Theory incorporating induced stress terms to accommodate anisotropic actuator materials. A twistextension coupled laminate was used to exemplify how twist can be directly induced into isotropic host structures using anisotropic actuation. Four anisotropic actuators with different material anisotropies were compared using this example. Finally, a laminate incorporating piezoelectric fiber composite actuators was manufactured and tested. Excellent agreement was found between the predicted and experimental response.
Impact of Gate Metal-Induced Stress on Performance Modulation in Gate-Last Metal–Oxide–Semiconductor Field-Effect Transistors

The effect of gate metal film stress on the performance of gate-last metal–oxide–semiconductor field-effect transistors (MOSFETs) with a W/TiN/SiO2 gate stack was investigated. The channel strain induced by the electrode film was controlled by the W film stress. The W film stress was determined by the deposition method and film thickness. The compressive and tensile stresses of the electrode film enhance nFET and pFET performances, respectively. The enhancements of the performances are introduced not only by the stress of the film on the channel but also by the stress of the film on the side in the groove of the gate-last MOSEFTs. Metal electrode stress can be a further controlling factor in the performance of scaled devices.
High efficiency harmonic control amplifier

A new high efficiency amplifier concept which ideally delivers 100% drain efficiency and class A gain is described. The power amplifier realized with a commercially available GaAs FET has demonstrated 74% power-added efficiency, 27.9 dBm output power, and 14.4 dB gain at 1.62 GHz.
High sensitivity integrated lateral detection in VCSELs

A simple and novel design for power monitoring, integrated in a VCSEL, is presented. A Schottky photodiode, placed close to the VCSEL, enables delivery of a photocurrent of several hundred µA from the lateral emitted light, throughout the whole light-current characteristics. It is shown that the Schottky contact significantly reduces the parasitic current in the cavity.
Measuring critical success factors of TQM implementation successfully – a systematic literature review

In times of globalisation and international trade, the concept of total quality management (TQM) as a strategy to enhance organisational performance is growing in importance. To exploit the benefits provided by TQM, organisations must manage the complex implementation process successfully. Therefore, organisations need to measure critical success factors (CSFs) when introducing TQM. However, previous research has developed a plethora of measurement instruments and researchers do not agree on certain factors or on one single measurement instrument. A systematic literature review is conducted to structure and clarify the scattered research field. The analysis of 145 studies reveals that CSFs can be classified into 11 distinct dimensions. The article proposes a three-level framework and a holistic set of measurement instruments to help researchers and managers measure each critical dimension in a timely and comprehensive manner. A focus group consisting of six quality managers validated these results. The study concludes with further findings and future research. Deficiencies of current measurements are presented and the article discusses the finding that human related factors are regarded as highly relevant but have remained low on many researchers’ and practitioners’ agendas. Hence, this article is a major contribution to structure the complex research field of measuring CSFs of TQM implementation.
Health Conditions, Substance Use, Physical Activity, and Quality of Life in Current and Former Baseball Players

Background: A comprehensive understanding of lifestyle (health conditions and substance use), health-related quality of life (HRQoL), flourishing (holistic representation of health), and physical activity can inform stakeholders (players, coaches, and clinicians) and help improve long-term health across the life span. Purpose: To describe health conditions (comorbidities or diagnoses), substance use, physical activity, HRQoL, and flourishing in current and former collegiate and professional baseball players and to assess the relationship between playing position and HRQoL/flourishing in former baseball players. Study Design: Descriptive epidemiology study. Methods: Eligible participants were those ≥18 years old with ≥1 season of collegiate or professional baseball experience. Participants completed a survey on health conditions (asthma, diabetes, hypertension, hypercholesterolemia, and depression), substance use (tobacco, alcohol, and energy drinks), physical activity (International Physical Activity Questionnaire–Short Form), HRQoL (Veterans Rand 12-Item Health Survey [VR-12] physical and mental component scores), and flourishing (Flourishing Scale). Adjusted multivariable regressions were performed for HRQoL and flourishing. Results: Overall, 260 baseball players opened the survey, and 214 (current players, 97; former players, 117) participated for an 82% response rate. Of the former players, 32% had hypertension or hypercholesterolemia. In addition, 26% of current players had used smokeless tobacco (median, 3 years; interquartile range [IQR], 1-5 years) as compared with 34% of former players (median, 15 years; IQR, 5-25 years). In addition, 14% of current players had used electronic cigarettes (median, 2 years; IQR, 0-4 years) as opposed to 3% of former (median, 3 years; IQR, 2-4 years). Energy drinks were consumed by 31% and 14%, respectively, of current and former players on at least a weekly basis. Current baseball players performed 8667 metabolic equivalents per week of physical activity as opposed to 3931 in former players. Pitching was associated with worse VR-12 Mental Component Scores (–5.0; 95% confidence interval, –9.0 to –1.0). Playing position was not related to VR-12 Physical Component Scores or flourishing in former baseball players. Conclusion: The similar smokeless tobacco prevalence between current and former baseball players suggests that they may start using tobacco products during baseball participation and continue after retirement. Similar reported HRQoL as compared with the general US population and high flourishing and physical activity levels suggest that baseball players may present with good musculoskeletal and psychological health.
Software outsourcing partnership process - a life cycle?

Van de Ven and Poole contend that all the specific theories of organizational change and development used in management research come back to four basic theories: life cycle theory, evolution theory, dialectic theory, and teleology, and that most of the organizational theories are some kind of combination of these four. In outsourcing research most of the researchers implicitly assume that an outsourcing process follows the life cycle theory. In this study we analysed a software outsourcing partnership model and found out that the model indeed followed life cycle theory.
Analysis of the Evolution of User Emotion and Opinion Leaders’ Information Dissemination Behavior in the Knowledge Q&A Community during COVID-19

Since its emergence in 2019, COVID-19 has quickly triggered widespread public discussion on social media. From 26 February 2020 to 26 September 2020, this study collected data on COVID-19-related posts in the knowledge Q&A community, identified 220 opinion leaders of this community, and used social network analysis and sentiment analysis to analyze the information exchange behavior and emotional evolution of the opinion leaders during COVID-19. The results show that the COVID-19 topic community could be divided into seven main categories. The information dissemination of opinion leader information dissemination network had low efficiency, multiple paths, and a high degree of control. In addition, the emotional evolution of users showed obvious phased characteristics. User emotion changed from initially strong negative to strong positive over the course of the pandemic and eventually tended to be objective and neutral as time passed and the event stabilized.
Spiral inductors integrated in MCM-D using the design space concept

High quality integrated spiral inductors are essential components of integrated microwave applications such as passive filters. In order to be able to determine the specific inductor geometry that provides the highest possible quality factor for a given inductance value and frequency behaviour, the concept of inductor design spaces is introduced. These design spaces link inductor quality factors with inductance values and frequency ranges. Using a new theoretical inductor model that allows the prediction of the behaviour of any coplanar multi-turn circular spiral inductor on a thin film multilayer MCM-D structure, the design spaces may be explored for the geometries that produce the highest quality factors. The paper describes both the calculation of the inductor model and the use of the design space concept. Finally, the application of this concept for the design of passive filters is indicated.
Monolithic implementation of air-buried microstrip lines for high-density microwave and millimeter wave ICs

This paper introduces a new type of monolithic transmission line structure for high-density microwave and millimeter wave integrated circuits. An air-buried microstrip line (ABMSL) has been monolithically fabricated on glass substrates using a new multi-layer process. The ABMSL has the advantages of low insertion loss and high isolation between transmission lines compared to conventional planar transmission lines such as microstrip lines and coplanar waveguides (CPWs), because of its geometric structure that has air as a dielectric medium and ground conductor walls formed to surround the strip conductor. Over a high frequency range (from 5 GHz to 40 GHz), the ABMSL has very low insertion loss below 0.08 dB/mm. The isolation between two ABMSLs that have 2 mm coupling length and are separated by a 60 /spl mu/m distance is less than -43 dB.
An Approach for Schema Extraction of NoSQL Columnar Databases: the HBase Case Study

Although NoSQL databases do not require a schema a priori, being aware of the database schema is essential for activities like data integration, data validation, or data interoperability. This paper presents a process for the extraction of columnar NoSQL database schemas. We adopt JSON as a canonical format for data representation, and we validate the proposed process through a prototype tool that is able to extract schemas from the HBase columnar NoSQL database system. HBase was chosen as a case study because it is one of the most popular columnar NoSQL solutions. When compared to related work, we innovate by proposing a simple solution for the inference of column data types for columnar NoSQL databases that store only byte arrays as column values, and a resulting schema that follows the JSON Schema format.
Floating solar photovoltaic plants in India – A rapid transition to a green energy market and sustainable future

The 18,000 square kilometers of water reservoirs in India can generate 280 GW of solar power through floating solar photovoltaic plants. The cumulative installed capacity of FSPV is 0.0027 GW, and the country plans to add 10 GW of FSPV to the 227 GW renewable energy target of 2022. The FSPV addition is small related to the entire market for solar energy, but each contribution is appreciated in the renewable energy market. FSPV could be a viable alternative for speeding up solar power deployment in the country and meeting its NDC targets. So far, the country has achieved the world's lowest investment cost for a floating solar installation. Despite the lower costs, generalizations are still premature because FSPV is still in its initial stages of market entry. Continuous innovation and timely adoption of innovative ideas and technology will support India in meeting its solar energy goals and progressing toward a more sustainable future. Governments must establish clear and enforceable policies to assist developers in reducing risks and increasing investor confidence in the sector. Economic and financial feasibility are examined, and various difficulties in technology, design, finances, environment, maintenance, and occupational health that impact the FSPV deployment are discussed. Based on the research, effective and comprehensive FSPV policy suggestions are included to support establishing an appropriate market, fostering competition and innovation, and attracting large-scale investment. This paper aims to stimulate interest among various policy developers, energy suppliers, industrial designers, ergonomists, project developers, manufacturers, health and safety professionals, executing agencies, training entities, and investment institutions of the FSPV plant to implement effective governance planning and help them to participate in their ways to assure sustainable growth.