Miracle-dz/UniFAR-FTUs huggingface dataset:
Preliminary Study on a Novel Protocol for Improving Familiarity with a Lower-Limb Robotic Exoskeleton in Able-Bodied, First-Time Users

Lower-limb exoskeletons have been created for different healthcare needs, but no research has been done on developing a proper protocol for users to get accustomed to moving with one. The user manuals provided also do not include such instructions. A pre-test was conducted with the TWIN (IIT), which is a lower-limb exoskeleton made for persons with spinal cord injury. In the pre-test, two healthy, able-bodied graduate students indicated a need for a protocol that can better prepare able-bodied, first-time users to move with an exoskeleton. TWIN was used in this preliminary study and nine users were divided to receive a tutorial or no tutorial before walking with the exoskeleton. Due to COVID-19 regulations, the study could only be performed with healthy, young-to-middle-aged lab members that do not require walking support. The proposed protocol was evaluated with the System Usability Scale, NASA Raw Task Load Index, and two custom surveys. The members who received the tutorial found it easy to follow and helpful, but the tutorial seemed to come at a price of higher perceived mental and physical demands, which could stem from the longer testing duration and the need to constantly recall and apply the things learned from the tutorial. All results presented are preliminary, and it is recommended to include biomechanical analysis and conduct the experiment with more participants in the future. Nonetheless, this proof-of-concept study lays groundwork for future related studies and the protocol will be adjusted, applied, and validated to patients and geriatric users.
On (Dis)Connections and Transformations: The Role of the Agricultural Innovation System in the Adoption of Improved Forages in Colombia

Feeding improvement strategies are key in increasing cattle productivity and reducing its environmental footprint. Nevertheless, Colombian tropical cattle systems still feature serious deficiencies in both forage quality and availability. As a result of past and on-going forage Research and Development (R&D) processes, institutions have released 23 grass and legume cultivars of superior characteristics in terms of forage quality, supply, or adaptation to different soil and climate conditions, while providing numerous environmental benefits. However, low levels of adoption are observed: although R&D processes are a necessary condition for adoption, they are still not sufficient to guarantee agricultural technification in Colombia. The ultimate success occurs only when end-users make effective use of a technology–a link constantly interrupted. Agricultural innovation requires complex processes of interaction in which knowledge is shared amongst organizations involved in the Agricultural Innovation System (AIS), namely: suitable links, attitudes, practices, governance structures, and policies. The objective of this study is to identify limitations and opportunities in R&D, adoption, and diffusion of forage technologies in Colombia from an AIS perspective. Particularly, we present a study case pertaining to research institutions only, to (a) map the involved actors and describe their roles and links, and (b) identify the events that marked the evolution of the AIS and the course of forage R&D in its research-related components. We applied a qualitative methodology based on focus group discussions, in-depth interviews, literature review, and historical analysis. Results show that the complex nature of institutions and the interactions between them determine the historical transformation of diffusion of forage technologies. The lack of connection between institutions and the weak intensity of the relationships, prevent the convergence of interests and objectives, leading to vicious cycles that hamper technology adoption. Insufficient synchronization between institutions of different nature (and even between those that share similar objectives) results in efficiency losses due to an unnecessary repetition of activities and processes. We provide recommendations for policy- and decision-makers that will help in both a restructuration of the AIS and a better allocation of funds for R&D, and thus support the development of more effective pathways for forage adoption and scaling.
Opportunities Surrounding the Use of Sargassum Biomass as Precursor of Biogas, Bioethanol, and Biodiesel Production

Climate change (along with other factors) has caused an increase in the proliferation of brown algal mats floating freely along the Atlantic Ocean since 2011. These brown algae mats are composed of sea plants from the Sargassum genus. The gargantuan agglomeration of biomass flows alongside currents and lands in beaches belonging to the Eastern coasts of the Mexican Caribbean and several other countries in the region. These events, dubbed golden tides, harm the local economy and environment. Current elimination approaches involve the mechanical harvesting of the Sargassum and ultimate landfill disposal. However, explorations into the commercial application of other brown algae have elucidated the potential of Sargassum as a feedstock for valorization. This review informs the trends, challenges, and opportunities presented by the coastal invasion of this biomass. Primarily, the potential use of this material is as a precursor in biorefineries where multiple value-added products are generated concurrent with the ultimate production of biofuels.
Find New RoadsTM? A Systematic Review on the Impacts of Off-Road Vehicle Activity on Soil, Vegetation, and Wildlife

The global use of off-road vehicles (ORVs) in natural environments has accelerated rapidly over the last few decades, resulting in significant social and environmental consequences. As the demand, use, and promotion of light-duty ORVs like all-terrain vehicles (ATVs), motorcycles, four-wheel drive trucks and sport utility vehicles (SUVs) increases in remote wilderness, the landscape is becoming fragmented into disorganized and destructive networks of trails and roads. Substantial ecological impacts to a wide range of ecosystem structures and functions will likely result from ORV activity. Applying a global systematic review, we examine 105 publications about plant, soil, and wildlife responses to ORV traffic in different habitats to help guide the direction of future research, monitoring programs, and mitigation efforts. Most studies investigated impacts to animals, followed by soils, then vegetative responses. Soil studies primarily focused on physical impacts to the soil (i.e., compaction, erosion, rut depth), but some studies suggest that soil chemical and biological properties may also be impacted by ORV traffic. The literature on plant responses to ORV activities primarily explored vegetation loss, although impacts on the plant community were also investigated. Animal studies investigated impacts of ORV use on invertebrates, mammals, birds, and to a lesser extent reptiles/amphibians, including population-level, community-level, and behavioral responses. Overall, research on environmental impacts of ORV traffic is biased to coastal and desert ecosystems in the northern hemisphere (primarily in the US), often does not address mechanisms that may produce ecological impacts (e.g., intensity of vehicular disturbance and ecosystem- or species-specific sensitivity to ORV activities), and frequently focused on short-term responses. More research is needed to understand the mechanisms that cause the different responses of soil, plant, and animals to ORVs over the long-term in a broad range of ecosystems to support real-time management and conservation efforts.
Topological One-Way Edge States in an Air-Hole Honeycomb Gyromagnetic Photonic Crystal

Topological one-way edge states have attracted increasing attention because of their intriguing fundamental physics and potential applications, particularly in the realm of photonics. In this paper, we present a theoretical and numerical demonstration of topological one-way edge states in an air-hole honeycomb gyromagnetic photonic crystal biased by an external magnetic field. Localized horizontally to the edge and confined in vertical direction by two parallel metallic plates, these unique states possess robust one-way propagation characteristics. They are strongly robust against various types of defects, imperfections and sharp corners on the path, and even can unidirectionally transport along the irregular edges of arbitrary geometries. We further utilize the one-way property of edge states to overcome entirely the issue of back-reflections and show the design of topological leaky wave antennas. Our results open a new door towards the observation of nontrivial edge states in air-hole topological photonic crystal systems, and offer useful prototype of robust topological photonic devices, such as geometry-independent topological energy flux loops and topological leaky wave antennas.
A Study on Propagation Models for 60 GHz Signals in Indoor Environments

The millimeter-waves band will enable multi-gigabit data transmission due to the large available bandwidth and it is a promising solution for the spectrum scarcity below 6 GHz in future generations of mobile networks. In particular, the 60 GHz band will play a crucial role in providing high-capacity data links for indoor applications. In this context, this tutorial presents a comprehensive review of indoor propagation models operating in the 60 GHz band, considering the main scenarios of interest. Propagation mechanisms such as reflection, diffraction, scattering, blockage, and material penetration, as well as large-scale path loss, are discussed in order to obtain a channel model for 60 GHz signals in indoor environments. Finally, comparisons were made using data obtained from a measurement campaign available in the literature in order to emphasize the importance of developing accurate channel models for future wireless communication systems operating in millimeter-waves bands.
The Impact of Age and BMI on the VWF/ADAMTS13 Axis and Simultaneous Thrombin and Plasmin Generation in Hospitalized COVID-19 Patients

Aging and obesity independently contribute toward an endothelial dysfunction that results in an imbalanced VWF to ADAMTS13 ratio. In addition, plasma thrombin and plasmin generation are elevated and reduced, respectively, with increasing age and also with increasing body mass index (BMI). The severity risk of Corona Virus Disease 2019 (COVID-19) increases in adults older than 65 and in individuals with certain pre-existing health conditions, including obesity (>30 kg/m2). The present cross-sectional study focused on an analysis of the VWF/ADAMTS13 axis, including measurements of von Willebrand factor (VWF) antigen (VWF:AG), VWF collagen binding activity (VWF:CBA), Factor VIII antigen, ADAMTS13 antigen, and ADAMTS13 activity, in addition to thrombin and plasmin generation potential, in a demographically diverse population of COVID-19 negative (−) (n = 288) and COVID-19 positive (+) (n = 543) patient plasmas collected at the time of hospital presentation. Data were analyzed as a whole, and then after dividing patients by age (<65 and ≥65) and independently by BMI [<18.5, 18.5–24.9, 25–29.9, >30 (kg/m2)]. These analyses suggest that VWF parameters (i.e., the VWF/ADAMTS13 activity ratio) and thrombin and plasmin generation differed in COVID-19 (+), as compared to COVID-19 (−) patient plasma. Further, age (≥65) more than BMI contributed to aberrant plasma indicators of endothelial coagulopathy. Based on these findings, evaluating both the VWF/ADAMTS13 axis, along with thrombin and plasmin generation, could provide insight into the extent of endothelial dysfunction as well as the plasmatic imbalance in coagulation and fibrinolysis potential, particularly for at-risk patient populations.
Elevated Levels of an Enzyme Involved in Coenzyme B12 Biosynthesis Kills Escherichia coli

E. coli is the best-studied prokaryote, and some strains of this bacterium are human pathogens. We show that when the level of the enzyme that catalyzes the penultimate step of vitamin B12 biosynthesis is elevated, the viability of E. coli decreases. ABSTRACT Cobamides are cobalt-containing cyclic tetrapyrroles involved in the metabolism of organisms from all domains of life but produced de novo only by some bacteria and archaea. The pathway is thought to involve up to 30 enzymes, five of which comprise the so-called “late” steps of cobamide biosynthesis. Two of these reactions activate the corrin ring, one activates the nucleobase, a fourth one condenses activated precursors, and a phosphatase yields the final product of the pathway. The penultimate step is catalyzed by a polytopic integral membrane protein, namely, the cobamide (5′-phosphate) synthase, also known as cobamide synthase. At present, the reason for the association of all putative and bona fide cobamide synthases to cell membranes is unclear and intriguing. Here, we show that, in Escherichia coli, elevated levels of cobamide synthase kill the cell by dissipating the proton motive force and compromising membrane stability. We also show that overproduction of the phosphatase that catalyzes the last step of the pathway or phage shock protein A prevents cell death when the gene encoding cobamide synthase is overexpressed. We propose that in E. coli, and probably all cobamide producers, cobamide synthase anchors a multienzyme complex responsible for the assembly of vitamin B12 and other cobamides. IMPORTANCE E. coli is the best-studied prokaryote, and some strains of this bacterium are human pathogens. We show that when the level of the enzyme that catalyzes the penultimate step of vitamin B12 biosynthesis is elevated, the viability of E. coli decreases. These findings are of broad significance because the enzyme alluded to is an integral membrane protein in all cobamide-producing bacteria, many of which are human pathogens. Our results may provide new avenues for the development of antimicrobials, because none of the enzymes involved in vitamin B12 biosynthesis are present in mammalian cells.
The Effectiveness of Mating Induction on Men’s Financial Risk-Taking: Relationship Experience Matters

Substantial evidence from experimental studies has shown that mating motivation increases men’s financial risk-taking behaviors. The present study proposed a new moderator, men’s past relationship experience, for this well-accepted link between mating motivation and financial risk-taking tendency. Heterosexual young men were randomly assigned to the mating condition and control condition, and they completed a set of financial risk-taking tasks and reported their past relationship experience. A significant main effect of mating motivation and a significant interaction effect between experimental conditions (mating group and control group) and relationship experience emerged, suggesting that mating motivation increased financial risk-taking tendency only among men who have never been committed in a romantic relationship, rather than those who have had such experience. This moderating effect was replicated in two experiments. The present study contributed to the understanding of individual differences in the relationship between mating motivation and male financial risk-taking. The present findings also have important implications for financial industry and gambling companies to better target clients and advertise their high-risk products.
Successful Results of Intracytoplasmic Sperm Injection of a Chinese Patient With Multiple Morphological Abnormalities of Sperm Flagella Caused by a Novel Splicing Mutation in CFAP251

Asthenospermia is one of the most important causes of male infertility. Among asthenospermia, multiple morphological abnormalities of sperm flagella (MMAF) are relatively rare idiopathic conditions characterized by multiple defects in sperm flagella. Although many studies focusing on the genetic factors of MMAF have been conducted, its pathogenesis and treatment effect remain largely unknown. Here, we report a male patient from a nonconsanguineous Chinese family who exhibited a typical MMAF phenotype revealed by morphological analysis. We identified splicing mutations in CFAP251 (c.1192-3C>G), and the mutation was proven to cause exon skipping. In addition, western blotting and immunofluorescence analysis of the spermatozoa from the proband and a control subject revealed a significantly lower expression of CFAP251 protein due to pathogenic mutation. Interestingly, the patient’s mother was a heterozygous carrier for the mutation, but his father was not, and finally, the inheritance pattern was proven to be maternal uniparental disomy. We applied an intracytoplasmic sperm injection and achieved a successful pregnancy. Above all, our findings expand the spectrum of CFAP251 pathogenic mutations and provide more indications for clinical genetic counseling and assisted reproductive treatment for such patients.
Cost and Toxicity Comparisons of Two IMRT Techniques for Prostate Cancer: A Micro-Costing Study and Weighted Propensity Score Analysis Based on a Prospective Study

Background Intensity modulated radiation therapy (IMRT) combined with androgen deprivation therapy (ADT) has become the standard treatment for patients with high-risk prostate cancer. Two techniques of rotational IMRT are commonly used in this indication: Volumetric Modulated Arc Therapy (VMAT) and helical tomotherapy (HT). To the best of our knowledge, no study has compared their related costs and clinical effectiveness and/or toxicity in prostate cancer. We aimed to assess differences in costs and toxicity between VMAT and HT in patients with high-risk prostate cancer with pelvic irradiation. Material and Methods We used data from the “RCMI pelvis” prospective multicenter study (NCT01325961) including 155 patients. We used a micro-costing methodology to identify cost differences between VMAT and HT. To assess the effects of the two techniques on total actual costs per patient and on toxicity we used stabilized inverse probability of treatment weighting. Results The mean total cost for HT, €2019 3,069 (95% CI, 2,885–3,285) was significantly higher than the mean cost for VMAT €2019 2,544 (95% CI, 2,443–2,651) (p <.0001). The mean ± SD labor and accelerator cost for HT was €2880 (± 583) and €1978 (± 475) for VMAT, with 81 and 76% for accelerator, respectively. Acute GI and GU toxicity were more frequent in VMAT than in HT (p = .021 and p = .042, respectively). Late toxicity no longer differed between the two groups up to 24 months after completion of treatment. Conclusion Use of VMAT was associated with lower costs for IMRT planning and treatment than HT. Similar stabilized long-term toxicity was reported in both groups after higher acute GI and GU toxicity in VMAT. The estimates provided can benefit future modeling work like cost-effectiveness analysis.
Epigenetics and Beyond: Targeting Histone Methylation to Treat Type 2 Diabetes Mellitus

Diabetes mellitus is a global public health challenge with high morbidity. Type 2 diabetes mellitus (T2DM) accounts for 90% of the global prevalence of diabetes. T2DM is featured by a combination of defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin. However, the pathogenesis of this disease is complicated by genetic and environmental factors, which needs further study. Numerous studies have demonstrated an epigenetic influence on the course of this disease via altering the expression of downstream diabetes-related proteins. Further studies in the field of epigenetics can help to elucidate the mechanisms and identify appropriate treatments. Histone methylation is defined as a common histone mark by adding a methyl group (-CH3) onto a lysine or arginine residue, which can alter the expression of downstream proteins and affect cellular processes. Thus, in tthis study will discuss types and functions of histone methylation and its role in T2DM wilsed. We will review the involvement of histone methyltransferases and histone demethylases in the progression of T2DM and analyze epigenetic-based therapies. We will also discuss the potential application of histone methylation modification as targets for the treatment of T2DM.
Natural Killer Cells in the Malignant Niche of Multiple Myeloma

Natural killer (NK) cells represent a subset of CD3- CD7+ CD56+/dim lymphocytes with cytotoxic and suppressor activity against virus-infected cells and cancer cells. The overall potential of NK cells has brought them to the spotlight of targeted immunotherapy in solid and hematological malignancies, including multiple myeloma (MM). Nonetheless, NK cells are subjected to a variety of cancer defense mechanisms, leading to impaired maturation, chemotaxis, target recognition, and killing. This review aims to summarize the available and most current knowledge about cancer-related impairment of NK cell function occurring in MM.
Human-human multi-threaded spoken dialogs in the presence of driving

The problem addressed in this research is that engineers looking for interface designs do not have enough data about the interaction between multi-threaded dialogs and manual-visual tasks. Our goal was to investigate this interaction. We proposed to analyze how humans handle multi-threaded dialogs while engaged in a manualvisual task. More specifically, we looked at the interaction between performance on two spoken tasks and driving. The novelty of this dissertation is in its focus on the intersection between a manual-visual task and a multi-threaded speech communication between two humans. We proposed an experiment setup that is suitable for investigating multi-threaded spoken dialogs while subjects are involved in a manual-visual task. In our experiments one participant drove a simulated vehicle while talking with another participant located in a different room. The participants communicated using headphones and microphones. Both participants performed an ongoing task, which was interrupted by an interrupting task. Both tasks, the ongoing task and the interrupting task, were done using speech. We collected corpora of annotated data from our experiments and analyzed the data to verify the suitability of the proposed experiment setup. We found that, as expected, driving and our spoken tasks influenced each other. We also found that the timing of interruption influenced the spoken tasks. Unexpectedly, the data indicate that the ongoing task was more influenced by driving than the interrupting task. On the other hand, the interrupting task influenced driving more than the ongoing task. This suggests that the multiple resource model [1] does not capture the complexity of the interactions between the manual-visual and spoken tasks. We proposed that the perceived urgency or the perceived task difficulty plays a role in how the tasks influence each other.