Miracle-dz/UniFAR-FTUs huggingface dataset:
Fucose-Rich Sulfated Polysaccharides from Two Vietnamese Sea Cucumbers Bohadschia argus and Holothuria (Theelothuria) spinifera: Structures and Anticoagulant Activity

Fucosylated chondroitin sulfates (FCSs) FCS-BA and FCS-HS, as well as fucan sulfates (FSs) FS-BA-AT and FS-HS-AT were isolated from the sea cucumbers Bohadschia argus and Holothuria (Theelothuria) spinifera, respectively. Purification of the polysaccharides was carried out by anion-exchange chromatography on DEAE-Sephacel column. Structural characterization of polysaccharides was performed in terms of monosaccharide and sulfate content, as well as using a series of non-destructive NMR spectroscopic methods. Both FCSs were shown to contain a chondroitin core [→3)-β-d-GalNAc-(1→4)-β-d-GlcA-(1→]n bearing sulfated fucosyl branches at O-3 of every GlcA residue in the chain. These fucosyl residues were different in pattern of sulfation: FCS-BA contained Fuc2S4S, Fuc3S4S and Fuc4S at a ratio of 1:8:2, while FCS-HS contained these residues at a ratio of 2:2:1. Polysaccharides differed also in content of GalNAc4S6S and GalNAc4S units, the ratios being 14:1 for FCS-BA and 4:1 for FCS-HS. Both FCSs demonstrated significant anticoagulant activity in clotting time assay and potentiated inhibition of thrombin, but not of factor Xa. FS-BA-AT was shown to be a regular linear polymer of 4-linked α-L-fucopyranose 3-sulfate, the structure being confirmed by NMR spectra of desulfated polysaccharide. In spite of considerable sulfate content, FS-BA-AT was practically devoid of anticoagulant activity. FS-HS-AT cannot be purified completely from contamination of some FCS. Its structure was tentatively represented as a mixture of chains identical with FS-BA-AT and other chains built up of randomly sulfated alternating 4- and 3-linked α-L-fucopyranose residues.
Risk Factors and Challenging Management of Lung Adenocarcinoma in Young Adult Women: Case Series

Introduction: Lung cancer found in young age is relatively rare with a percentage of cases only 1.4% of overall lung cancer cases in the world. Case: We reported two cases of lung adenocarcinoma in young women aged less than 30. The first case was lung adenosquamous carcinoma in a 28-year-old woman, a passive smoker, who had a family history of cancer. She had the mutation of epidermal growth factor receptor (EGFR) exon 19 deletion and received 1st generation of tyrosine kinase inhibitor. Since the patient was diagnosed at advanced stage with poor performance status, she died within 2 months after being diagnosed. The second case was lung adenocarcinoma in a 23-year-old woman. The patient was a passive smoker and had a history of cancer in the family. She was diagnosed at an advanced stage but with good performance status. The patient underwent chemotherapy with Pemetrexed-Platinum in 6 cycles and 15 cycles of radiotherapy. Conclusion: Lung cancer at a young age is more common in non-smoking female with the histopathology type adenocarcinoma. Non-specific early symptoms become a problem in the early enforcement of lung cancer at a young age. Many cancer-related issues occur in young cancer patient such as premature death, increased dependence on parents, difficulty in school and work due to medication, and reproductive disturbance.
Design of Microstrip Patch Antenna for 5G Applications

Millimeter-wave wireless technology (mmWave) has become a part of human life for fast and secure data transmission. This document introduces a 37GHz resonant frequency square microstrip patch antenna for mm Wave wireless communication. The antenna was designed and tested on a Rogers RT5880 board with a relative permittivity of 2.2 and a loss factor of 0.0009. Uses electromagnetic simulation software High Frequency Structure Simulator. The result of this paper shows minimal return loss -0.0812 dB, gain -1.205 dB, and impedance bandwidth 16.22% at 37 GHz resonant frequency. The voltage standing wave ratio (VSWR), radiation pattern has also presented for the proposed antenna which can be strong candidate for 5G mmWave cellular communication.
Band Gap Engineering and Relationship with Luminescence in Rare-Earth Elements Doped ZnO: An Overview

ABSTRACT This review is focused upon unique optical properties of rare earth (RE) doped ZnO nanostructures derived by a cost-effective sol-gel method. Doping of RE elements improves the properties of ZnO due to their special electronic structure, small crystal field splitting and partially filled 4f energy level, surrounded by full 5s and 5p orbitals. RE-element-induced defects regulate energy transfer dynamics, which can add superior features in ZnO. The biocompatibility of ZnO along with its special calibre of sustained tuneable features by RE doping makes it an excellent candidate for a highly demanding field, i.e. bio-imaging. Here, five RE elements, Tb, Ce, Gd, Y and Eu, are chosen to comprehensively review alterations in the optical parameters of ZnO by their doping. Band gap tuning and luminous properties of RE doped ZnO nanostructures, as well as their features and applications in diverse sectors, are majorly highlighted.
Botox Therapy for Hypertrophy of the Masseter Muscle Causes a Compensatory Increase of Stiffness of Other Muscles of Masticatory Apparatus

Little is known about the nature of masseter muscle hypertrophy. We investigated the masseter muscle stiffness change after a single intra-masseteric session of Botox injections in people with benign bilateral masseter hypertrophy and the effect of the treatment on the stiffness of the temporalis muscle. Stiffness of the muscles was measured with shear-wave elastography at baseline and 3 weeks after Botox injections in 22 otherwise healthy people. Before the treatment, the stiffness of the masseter was lower than of the temporalis muscle (10.18 ± 1.67 kPa vs. 11.59 ± 1.54 kPa; p = 0.002). After the treatment, this difference increased (6.38 ± 1.34 vs. 13.10 ± 1.92; p < 0.0001). The drop in the stiffness of the masseter muscle was symmetrical (left side by 3.78 kPa; right side by 3.83 kPa). No differences between the left and right sides of the face in terms of muscle stiffness were observed. The study shows that Botox injections reduce stiffness of the masticatory muscles which, in turn, increases the stiffness of the temporalis muscles. Due to the knock-on effect of the change in the masseter function on the other masticatory muscles, simultaneous evaluation and treatment of the temporalis muscle may be required to ensure the desired functional and cosmetic effect.
Correlation of SVINT and Sensory Organization Test in Children with Hearing Loss

Objective: The skull vibration-induced-nystagmus test (SVINT) is a noninvasive and effective screening tool for the function of the otolith and canal structures in children. It can instantaneously assess vestibular asymmetry. This study aimed to analyze the SVINT results of healthy children vs. children with hearing loss (HL) and to correlate it with sensory organization test (SOT) results as a functional balance evaluation tool. Design: This case-controlled study compared the results of SVINT to the results of the SOT of the computerized dynamic posturography (CDP) in a control group of 120 healthy normal-hearing children (i.e., NH group) vs. hearing loss (HL) group of 60 children, including 30 children with hearing aids (HAs) and 30 children with a unilateral cochlear implant (CI). The SVINT results were compared to the caloric test (CaT) and video head impulse test (vHIT) and associated with SOT scores. Results: Thirty-one children in the HL group had normal SVINT and normal SOT results. A total of 21 children in the HL group had SVINT-negative and abnormal results in the SOT (possibly due to bilateral vestibular loss (BVL)). Eight children in the HL group had positive SVINT and abnormal SOT results. However, none of the children had only positive SVINT with normal SOT findings. Moreover, 52% of children had a normal result on both the SOT and CaT, whereas 27% had abnormal results on both tests (17% bilateral weakness and 10% unilateral), and 22% had the only result of the SOT suggesting a functional abnormality. Similarly, when associating the result to vHIT, 51% had normal results on both tests, and 25% had abnormal results (13% bilateral and 12% unilateral weakness). Conclusions: SVINT findings can be correlated with SOT findings in the case of the unilateral vestibular lesion (UVL), which adds a diagnostic value in these pediatric cases but may differ in the case of the bilateral vestibular lesion (BVL). However, SVINT findings need to be cautiously interpreted in light of other test findings such as the SOT, CaT, and vHIT.
Research Progress on G-Quadruplexes in Human Telomeres and Human Telomerase Reverse Transcriptase (hTERT) Promoter

The upregulation telomerase activity is observed in over 85-90% of human cancers and provides an attractive target for cancer therapies. The high guanine content in the telomere DNA sequences and the hTERT promoter can form G-quadruplexes (G4s). Small molecules targeting G4s in telomeres and hTERT promoter could stabilize the G4s and inhibit hTERT expression and telomere extension. Several G4 ligands have shown inhibitory effects in cancer cells and xenograft mouse models, indicating these ligands have a potential for cancer therapies. The current review article describes the concept of the telomere, telomerase, and G4s. Moreover, the regulation of telomerase and G4s in telomeres and hTERT promoter is discussed as well. The summary of the small molecules targeting G4s in telomeric DNA sequences and the hTERT promoter will also be shown.
Space prototypes for achieving "Ubiquitous Computing": Reconfiguring the existing space with physical interactions

In this project, “Ubiquitous Computing” space prototypes with new embedment of context information are studied. Through the related theories, research models and experiments, the prototypes for future information space and user styles are proposed, including space modules, user behaviors with physical HCI interactions, and required information technology. Space prototypes for exhibition and lab areas with supported infrastructure and interface are tested in the experiments.
Domain Adaptive Log Anomaly Prediction for Hadoop System

Hadoop provides a powerful platform that allows reliable, scalable, and distributed processing of massive data sets across a cluster of computers. Log data record events taken place in the Hadoop system that helps to understand system activities and diagnose problems. However, system upgrades and updates often change the syntax and patterns of logs, rendering the machine-learning models that were designed for the legacy system ineffective. Retraining the machine-learning models with new data sets from scratch might improve the accuracy of the machine-learning model. Nevertheless, annotating new data sets is often time consuming and labor intensive. In this article, we propose a domain adaptive log anomaly prediction framework called LogAT to effectively transfer learned knowledge from the existing labeled data set (source domain) to the new unlabeled data set (target domain) by adopting an unsupervised domain adaption method. Furthermore, a hierarchical anomaly knowledge graph has been constructed to represent the domain knowledge that facilitates the subsequent detection and diagnosis of system faults. Extensive experiments have been conducted on public and real-world data sets to validate the effectiveness of the proposed framework as well as each module. Our results show that LogAT achieves superior performance over the state-of-the-art methods for predicting log anomalies and acquiring considerable performance improvement in terms of AUC-ROC score on different Hadoop application data sets.
A phase 1/2 study of REGN4336, a PSMAxCD3 bispecific antibody, alone and in combination with cemiplimab in patients with metastatic castration-resistant prostate cancer.

TPS5105 Background: Prostate cancer is the leading cause of new cancer diagnoses and the second most common cause of cancer-related death in American men. Prognosis is especially poor for men with metastatic castration resistant prostate cancer (mCRPC). Prostate-specific membrane antigen (PSMA) is highly expressed on malignant prostate tissue but shows limited expression on normal tissue. As such, PSMA is an excellent research target for treatment of mCRPC. REGN4336 is a PSMAxCD3 bispecific antibody designed to facilitate T-cell–mediated killing of PSMA-expressing tumor cells. In preclinical models, REGN4336 demonstrated strong PSMA-dependent antitumor activity that was dose-dependent. Preclinical data also support clinical research into the combination of REGN4336 with cemiplimab (anti–programmed cell death-1) for treating mCRPC. Methods: This is an open-label, Phase 1/2, first-in-human, multicenter dose-escalation study with dose expansion evaluating safety, tolerability, pharmacokinetics (PK), and antitumor activity of REGN4336 administered subcutaneously alone and in combination with intravenous cemiplimab in patients with mCRPC (NCT05125016). Patients must have received at least two prior lines of systemic therapy approved for metastatic and/or castration-resistant disease including a second-generation anti-androgen therapy. In this study, REGN4336 as monotherapy is administered weekly but may be extended to once every 3 weeks following identification of the minimal pharmacologically active dose. REGN4336 in combination with cemiplimab (350 mg) will be administered once every 3 weeks after a 4-week REGN4336 monotherapy lead-in cycle. Study therapies are administered until disease progression, intolerable adverse events, withdrawal of consent, or study withdrawal criterion is met. The primary objectives in dose escalation are to evaluate the safety, tolerability, PK, and recommended phase 2 dosing regimen (RP2DR) of REGN4336 alone and in-combination with cemiplimab. Expansion cohort(s) will be enrolled once RP2DRs have been determined. During the expansion phase, the primary objective is to assess clinical activity, as measured by objective response rate with REGN4336 alone or in combination with cemiplimab per modified Prostate Cancer Working Group 3 criteria. At selected sites, PSMA positron emission tomography/computed tomography scans will be performed at predefined timepoints on study. This study is currently open to enrollment. Clinical trial information: NCT03088540.
Preliminary data from an ongoing phase 1 dose-escalation study of CCX559, an orally administered small molecule PD-L1 inhibitor, in patients with advanced solid tumors.

2593 Background: The novel small molecule CCX559 is a highly potent and selective PD-L1 inhibitor that induces the dimerization and internalization of cell-surface PD-L1. CCX559, when orally administered in animal models, demonstrated anti-tumor efficacy, including the ability to induce complete responses (Li C, et al. Cancer Res 2021;81(13_Suppl): Abstract nr 1274). Safety pharmacology and toxicology studies in animals demonstrated an acceptable safety profile for CCX559. Taken together, the preclinical data supports the initiation of human trials in patients with advanced solid tumors. PD-(L)1 therapies have been shown to increase peripheral T cell activation and cytokines such as IFNγ and CXCL9 in patients (Herbst RS, et al. Nature.2014; 515(7528):563–567). Methods: This phase 1, first-in-patient, multicenter, open-label, dose-escalation study evaluates safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary anti-tumor activity of CCX559 in patients with refractory, locally advanced or metastatic solid tumors. CCX559 is dosed orally once daily with a starting dose level of 30 mg. Dose escalation/de-escalation is based on the Bayesian Optimal Interval (BOIN) design. PBMC and plasma samples were collected from patients over the first 2 cycles (6 weeks) of treatment, and PD assays were performed, including measurement of cytokines and T cell proliferation. Results: As of February 1, 2022, one patient per cohort was enrolled at the 30 mg and 60 mg levels, and 9 patients were enrolled in the 120 mg dose cohort. Of the 11 patients enrolled, 5 patients (all 120 mg cohort) remain on treatment. No DLTs, treatment-related SAEs, or severe (Grade 3 or higher) treatment-related AEs have been reported. PD assays have been performed with samples from the 30 mg (n=1), 60 mg (n=1), and 120 mg (n=3) cohorts. Patients in all three cohorts showed increased peripheral CD4 and CD8 T cell proliferation starting in the first cycle (21 days) of treatment, as measured by Ki67 positivity. Increases in plasma IFNγ, CXCL9, CXCL10, and CXCL11 levels were observed, in particular in one patient (120 mg cohort) starting 15 days after treatment initiation. Conclusions: Initial results from the phase 1 dose-escalation study of CCX559 indicate on-target PD effects consistent with PD-L1 inhibition. Updated PD data, together with the safety and PK profile, will be presented. Clinical trial information: ACTRN12621001342808.
How to Develop Diversity Management Competencies in the Private Sector in Saudi Arabia

This study identifies factors, which stimulate and develop diversity management competency within Saudi Arabia’s private sector. A quantitative exploratory approach is adopted here, in which 210 interviews were conducted with human resources management teams and employees in private Saudi enterprises across different sectors of activity: health, education, oil, and financial. The data collected was analyzed using AMOS 24. Based on the results, a research model was constructed in which three main determinants of diversity management competency were identified for the success of diversity management: leadership competencies (cognitive and communication); empowerment; and diversity training. The results show that there is complementarity between those factors, but that leadership diversity competencies are the most important, and especially the cognitive aspect. Added to this is diversity training, which affects diversity awareness and inclusiveness. It is concluded that factors related to the internal development of diversity management competency are cultivated and constructed. The research model can help managers in developing diversity management competencies to generate successful diversity management processes. Due to the limited literature on diversity management in general and for Saudi Arabia especially, this research enriches the existing literature. The model developed here can guide directors of multinationals based in Saudi Arabia and facilitate the implementation of diversity management for Saudi-owned companies who intend to adopt diversity management initiatives as a solution for development. This research is important for both theoretical and operational approaches, defining a critical aspect of diversity management through the definition and development of an interesting tool: diversity management competencies. The development of such competencies may be of benefit for organizations in more easily facing and managing diversity.
2 The Size of the Web Graph

The global usage and continuing exponential growth of the World-Wide-Web poses a host of challenges to the research community. In particular, there is an urgent need to understand and manage the dynamics of the Web, in order to develop new techniques which will make the Web tractable. We provide an overview of recent statistics relating to the size of the Web graph and its growth. We then briefly review some of the key areas relating to Web dynamics with reference to the recent literature. Finally, we summarise the talks given in a recent workshop devoted to Web dynamics which was held in the beginning of January 2001 at the University of London.
Correlation between direct and indirect VO2max measurements in indoor soccer players

The importance of the morphofunctional qualities to greater efficiency in sports has increased the interest on the improvement on the physical fitness levels of athletes. However, not many studies on the physiological variables of indoor soccer are available in the world scientific literature. Thus, the objective of this work was to verify the existence of correlation between the direct and indirect VO 2max measurement tests in indoor soccer players. Thirteen indoor soccer players with age of 18.6 ± 1.9 years, height of 177.1 ± 3.5 cm, weight of 68.5 ± 9.5 kg and body mass index (BMI) of 21.7 ± 2.3 kg/m2 were analyzed. For the direct VO 2max measurement, the computerized ergospirometric system was used (VO2000, Aerosport, Medgraphics, St. Paul, Minnesota) and for the indirect VO 2max measurement, the 3,200 m field test was performed. The statistical analysis was elaborated through the t-Student test for paired samples and through the Pearson correlation coefficient. The VO 2max values obtained in the direct measurement test presented no significant differences in relation to the indirect measurement (62.8 ± 10.1 vs. 58.5 ± 8.5 ml/kg/min, respectively). When the VO 2max values obtained in both tests were correlated, a strong correlation (r = 0.72) was observed. In short, the indirect measurement tests presented good acceptance among indoor soccer players due to the high correlation with the direct measurement tests, the low cost and the attainment of important information that will be helpful in the training prescription and follow-up.
Vision sensor‐based SLAM problem for small UAVs in dynamic indoor environments

In recent years, with the rapid development of artificial intelligence, machine vision and other related technologies, there has been a demand for higher levels of intelligence in UAVs. There are many excellent SLAM systems available, but most of them assume that their working environment is static. When there are dynamic objects in the environment the localization and mapping accuracy of the SLAM system is reduced, and it can even cause its tracking to fail. To solve this problem. In this paper, we propose a target detection‐based SLAM algorithm for real‐time operation in crowded dynamic environments. The algorithm removes feature points of dynamic objects from key frames and then constructs a point cloud map of based on the state‐of‐the‐art SLAM system ORB‐SLAM3. Finally, the proposed method is validated and evaluated on multiple dynamic datasets and real environments. The results show that the algorithm in this paper outperforms other visual SLAM algorithms in terms of localization and map building accuracy in more highly dynamic datasets, while guaranteeing performance.