Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of endoscopic submucosal dissection on post-operative early treatment effectiveness and serum TAT-2 and GP73 expression levels in patients with early gastric cancer

The present study aimed to explore the effectiveness of endoscopic submucosal dissection (ESD) in the treatment of early gastric cancer (EGC) and its effect on serum tumor-associated trypsin-2 (TAT-2) and Golgi protein 73 (GP73) expression levels to provide a reference for the treatment of EGC. TAT-2 is a proteolytic target enzyme for tumor-associated trypsin inhibitor that has been previously reported to enhance invasion by promoting extracellular matrix degradation. GP73 is a novel type II Golgi membrane protein of unknown function that is expressed in the hepatocytes of patients with adult giant-cell hepatitis. A total of 161 patients with EGC treated at our hospital from April 2013 to February 2014 were selected as the study subjects. Among these, 86 patients underwent ESD (group A) and the remaining 75 underwent endoscopic mucosal resection (group B). Treatment effectiveness, incidence of complications and adverse reactions, operation time, intraoperative blood loss and length of hospital stay, as well as serum TAT-2 and GP73 expression levels, were compared between the two groups. The treatment effectiveness was significantly higher in group A than in group B (P<0.05). However, there was no significant inter-group difference in terms of incidence of complications/adverse reactions (P>0.05). After treatment, serum TAT-2 expression levels decreased in both groups (P<0.05) and serum TAT-2 expression levels were lower in group A than in group B (P<0.05). Furthermore, serum GP73 expression levels were significantly elevated in both groups (P<0.05). Kaplan-Meier survival analysis indicated no significant inter-group difference in the 5-year survival rate (P>0.05). In conclusion, ESD had a good therapeutic effect on EGC and is able to decrease serum TAT-2 expression levels and increase serum GP73 expression levels. The present study was registered into the Chinese Trials Registry (registration no. NCT02157534).
Design, Synthesis, Molecular Modeling and Antitumor Evaluation of Novel Indolyl-Pyrimidine Derivatives with EGFR Inhibitory Activity

Scaffolds hybridization is a well-known drug design strategy for antitumor agents. Herein, series of novel indolyl-pyrimidine hybrids were synthesized and evaluated in vitro and in vivo for their antitumor activity. The in vitro antiproliferative activity of all compounds was obtained against MCF-7, HepG2, and HCT-116 cancer cell lines, as well as against WI38 normal cells using the resazurin assay. Compounds 1–4 showed broad spectrum cytotoxic activity against all these cancer cell lines compared to normal cells. Compound 4g showed potent antiproliferative activity against these cell lines (IC50 = 5.1, 5.02, and 6.6 μM, respectively) comparable to the standard treatment (5-FU and erlotinib). In addition, the most promising group of compounds was further evaluated for their in vivo antitumor efficacy against EAC tumor bearing mice. Notably, compound 4g showed the most potent in vivo antitumor activity. The most active compounds were evaluated for their EGFR inhibitory (range 53–79%) activity. Compound 4g was found to be the most active compound against EGFR (IC50 = 0.25 µM) showing equipotency as the reference treatment (erlotinib). Molecular modeling study was performed on compound 4g revealed a proper binding of this compound inside the EGFR active site comparable to erlotinib. The data suggest that compound 4g could be used as a potential anticancer agent.
Current Research in Ecological and Social Psychology Attitudes toward COVID-19 vaccines and vaccine uptake intent in China: The role of collectivism, interpersonal communication, and the use of news and information websites

Vaccines can be an eﬀective way to help prevent COVID-19 infections. However, in the age of “infodemic" and people holding diﬀerent values, promoting COVID-related prevention can be diﬃcult. Based on a survey of 460 Chinese residents in March 2021, the present analysis aims to provide a detailed understanding of the role of val- ues and information sources on the Chinese’s attitudes toward COVID-19 vaccines and their vaccination intent. Results revealed that collectivism and the use of mainstream websites were positively associated with value- expressive attitudes, trust toward vaccines, and norms, which in turn predicted vaccination intent. Furthermore, collectivism was negatively associated with attitudes toward inconvenience or minor side eﬀects, whereas in- terpersonal communication was positively associated with such attitudes. Overall, collectivism appeared to be a much stronger predictor of the Chinese’s vaccination intent than the media and interpersonal communication. Although this research was conducted in China, where the pace of mass vaccination was fast, the results can provide insights on what might contribute to the success or failure of a vaccination campaign and be used to compare COVID-19 vaccination campaigns in other countries.
CoP: a database for characterizing co-expressed gene modules with biological information in plants

UNLABELLED Using a large dataset (10 022 assays) obtained from public plant microarray databases, we developed the CoP database for associating co-expressed gene modules with biological information such as gene ontology terms and, if available, metabolic pathway names. The Confeito algorithm developed previously in our laboratory, which is suitable to calculate the interconnectivity between genes in co-expressed gene network, was applied to extract co-expressed gene modules. The database includes the gene modules for Arabidopsis thaliana (thale cress) and seven crops, Glycine max (soybean), Hordeum vulgare (barley), Oryza sativa (rice), Populus trichocarpa (poplar), Triticum aestivum (wheat), Vitis vinifera (grape) and Zea mays (maize). AVAILABILITY The CoP database is available at: http://webs2.kazusa. or.jp/kagiana/cop0911/.
Qualitative study of primary care clinicians’ views on point-of-care testing for C-reactive protein for acute respiratory tract infections in family medicine

Objective To explore clinicians views of the barriers and facilitators to use of C-reactive protein (CRP) point-of-care tests (POCT) in US family medicine clinics for the management of acute respiratory tract infections (ARTIs) in adults. Setting Five family medicine clinics across two US states. Participants 30 clinicians including 18 physicians, 9 physician residents, 2 physician assistants and 1 nurse practitioner, took part in the study. Design A qualitative study using a grounded theory approach to thematically analyse focus group interviews. Results These clinicians had limited access to diagnostic tests for patients with ARTI, and very little knowledge of CRP POCT. Three major themes were identified and included the potential clinical role of CRP POCT, concerns related to implementing CRP POCT and evidence needed prior to wider adoption in family medicine. Clinicians believed CRP POCT could support decision-making for some presentations of ARTIs and patient populations when used in conjunction with clinical criteria. Clinicians had concerns about possible overuse and inaccuracy of CRP POCT which they believed might increase antibiotic prescribing rates. Other concerns identified included integration of the test with clinic workflows and cost-effectiveness. Conclusions Clinicians stand at the forefront of antibiotic stewardship efforts, but have few diagnostic tests to help them confidently manage ARTIs. CRP POCT may facilitate some aspects of clinical practice. Incorporating CRP POCT with clinical guidelines may strengthen utility of this test, when there is diagnostic uncertainty.
Synoptic and mesoscale atmospheric features over the ice‐covered portion of the Fram Strait in spring

Data obtained during the Coordinated Eastern Arctic Experiment (CEAREX) from March 31 to April 20, 1989, from two ice camps in the pack ice region in the Fram Strait have been analyzed. The data show that the total period can be divided into two periods or regimes divided by a transition period. The first period was a radiative type, characterized by very low surface temperatures and low wind speeds. Fairly regular oscillations between southerly and northerly winds were caused by small-scale disturbances in the surface pressure field, associated with upper level waves of large amplitude. During a transition period toward an “advective weather type” on April 11 a sharp frontal zone passed both ice camps. The front was associated with a small-scale low which had formed over the ice on the shallow but intense baroclinic zone along the northeastern Greenland coast. Mesoscale vortices of this type may, if numerous enough, affect the horizontal transfer of heat from lower latitudes toward Arctic regions as well as the ice drift through the Fram Strait.
Postglacial chironomid assemblage succession in northernmost Ungava Peninsula, Canada

Sediment cores spanning the postglacial period were recovered from two coastal freshwater basins located 300 km apart in northernmost Ungava (Nunavik, Canada). A basal date from the sequence recovered near Wakeham Bay suggests that the region was ice‐free by as early as 9600 cal. a BP. The initial development of both investigated lacustrine ecosystems was characterised by chironomid assemblages strongly dominated by the Subtribe Tanytarsina. These early postglacial assemblages showed greatly reduced diversity but much greater abundance than during subsequent periods of lake evolution. An abrupt and distinct turnover in sedimentary chironomid assemblage composition and productivity, marked by a switch to a dominance of Orthocladiinae, occurred around 6 ka BP. This turnover likely corresponds with a significant disturbance in the regional environment, which could be linked to the final disappearance of the last remnants of the Laurentide Ice Sheet. These findings, based on the first palaeolimnological investigations undertaken in northernmost Ungava, provide new insights into lateglacial and postglacial faunal recolonisation patterns in aquatic ecosystems of the eastern Canadian Arctic. Copyright © 2009 John Wiley & Sons, Ltd.
Pollen Record Preservation Processes in the Salem Neck Sewage Plant Shell Midden (19-ES-471), Salem, Massachusetts, U.S.A.

The pollen spectra of sediment inside shell valves that were recovered concave-side-down at the Salem Neck Sewage Plant Shell Midden in Salem, Massachusetts, U.S.A. , were compared with those of unprotected midden matrix. The data indicates that shells will preserve prehistoric pollen spectra from the percolating rainwater, free oxygen, and aerobic fungi that move and destroy pollen in archaeological sites that are exposed at the surface to the natural elements.
Surface Motions on Near-Distance Rock Sites in the 2011 Tohoku-Oki Earthquake

This paper selects several sites intended to represent relatively undistorted rock motions just inland from the faulting in the 2011 Tohoku-oki earthquake. Sites were selected for relatively high values of VS30 and for absence of strong site resonances. At these sites, ground motions at the surface were moderate, with peak accelerations of up to ∼330 cm/s2 and peak velocities up to ∼45 cm/s. Although moderate, these records imply that the strong motion generating area of the Tohoku earthquake was as much as ten times more energetic than the 1985 Michoacan earthquake, for which ground motions on rock were recorded above a strong motion generating area. These results suggest that a wide range of source parameters can occur in subduction zone earthquakes.
Processes and trends of the land use change in Aksu watershed in the central Asia from 1960 to 2008

Land use change (LUC) in trans-boundary watersheds is of great importance to environmental assessment. The Aksu River is the largest trans-boundary river crossing Kyrgyzstan and China, but there was little information on the LUC of the watershed. We quantitatively investigated the processes and trends of its LUC by using analytic models based on the land use data derived from the remote sensing images and topographic maps. The LUC was in the quasi-balanced status with a slight difference between the loss and the gain of the area for most land use types during the period of 1960−1990, whereas transferred to the unbalanced status with significant difference between the loss and gain of the area during the period of 1990−2008. At the same time, land conversion direction changed from two-way transition to one-way transition for the most land use types. The integrated rate of net change of land use during the period of 1990−2008 is 2.1 times of that during the period of 1960−1990. Information on the processes and trends of LUC is valuable for better understanding the environmental changes across the whole trans-boundary watershed, and helpful to decision-making management for Kyrgyzstan and China.
Stat Acetylation--A Key Facet of Cytokine Signaling?

Modification of proteins by addition of, for example, phosphate groups to particular amino acids in the protein is an important way to regulate the protein's activity. In their Perspective, [O'Shea][1] and colleagues discuss the intriguing finding that addition of an acetyl group to an amino acid in an important group of transcription factors called Stats might regulate their activity ([ Yuan et al .][2]). [1]: http://www.sciencemag. org/cgi/content/full/307/5707/217 [2]: http://www.sciencemag. org/cgi/content/short/307/5707/269
Spatial Pattern and Order in Sunbelt Retailing: Shopping in Phoenix in the Twenty-First Century

Understanding the complexity of store location in sprawling polycentric cities requires exploitation of new spatial analysis methods that can decipher patterns in georeferenced point data. This article shows how the intrametropolitan location of retailing is best understood as a series of interconnected spatial distributions with varying order-based characteristics. A scattered pattern, which initially appears random or chaotic, is a web of differentiated spatial regimes containing wide-ranging order. A variety of clustering and colocation methods are used to uncover spatial patterns of retailing in Phoenix, Arizona. The analysis simultaneously identifies establishment associations and disassociations within and across sectors. Results show that clothing and motor vehicles are the most likely to cluster next to establishments in the same sector. These sectors also have strong intersectoral relationships across retailing. We find limited evidence that the size of establishments significantly increases with distance from sectoral mean centers. Geospatial technologies are increasingly used by individual retailers to locate and manage their facilities. It is important that scholarly analysis of retailing spatial patterns keeps pace, especially as cities grow and land use and land value patterns become more complex.
Draft genome of the Antarctic dragonfish, Parachaenichthys charcoti

Abstract The Antarctic bathydraconid dragonfish, Parachaenichthys charcoti, is an Antarctic notothenioid teleost endemic to the Southern Ocean. The Southern Ocean has cooled to −1. 8ºC over the past 30 million years, and the seawater had retained this cold temperature and isolated oceanic environment because of the Antarctic Circumpolar Current. Notothenioids dominate Antarctic fish, making up 90% of the biomass, and all notothenioids have undergone molecular and ecological diversification to survive in this cold environment. Therefore, they are considered an attractive Antarctic fish model for evolutionary and ancestral genomic studies. Bathydraconidae is a speciose family of the Notothenioidei, the dominant taxonomic component of Antarctic teleosts. To understand the process of evolution of Antarctic fish, we select a typical Antarctic bathydraconid dragonfish, P. charcoti. Here, we have sequenced, de novo assembled, and annotated a comprehensive genome from P. charcoti. The draft genome of P. charcoti is 709 Mb in size. The N50 contig length is 6145 bp, and its N50 scaffold length 178 362 kb. The genome of P. charcoti is predicted to contain 32 712 genes, 18 455 of which have been assigned preliminary functions. A total of 8951 orthologous groups common to 7 species of fish were identified, while 333 genes were identified in P. charcoti only; 2519 orthologous groups were also identified in both P. charcoti and N. coriiceps, another Antarctic fish. Four gene ontology terms were statistically overrepresented among the 333 genes unique to P. charcoti, according to gene ontology enrichment analysis. The draft P. charcoti genome will broaden our understanding of the evolution of Antarctic fish in their extreme environment. It will provide a basis for further investigating the unusual characteristics of Antarctic fishes.
Effects of Sediment Composition on Growth of Submersed Aquatic Vegetation

Abstract : Experiments with two submersed aquatic macrophytes, Myriophyllum spicatum L. and Hydrilla verticillata (L.f.) Royle, grown on 40 different sediments from 17 geographically widespread North American lakes, indicated tenfold and twentyfold declines in growth with increasing sediment organic matter up to a concentration of about 20 percent dry sediment mass. Poor growth was obtained also on inorganic sediments with a sand fraction exceeding 75 percent dry sediment mass. Diminished growth on organic sediments occurred at low values of sediment density, and on sands at high values of sediment density. Differential centrifugation of organic sediment, facilitating an increase in sediment density with no change in organic matter content, stimulated Hydrilla growth, indicating that sediment density rather than organic matter content was most influential in regulating growth. Macrophyte growth and nutrient accumulation in shoots were closely correlated, but essentially unrelated to concentrations of nutrients in shoots. Additions of phosphorus and iron in combination to organic sediments with nitrogen supplied in the overlying solution resulted in significant growth increases in Hydrilla, suggesting that diminished growth on unfavorable sediments was caused by multiple nutrient limitation. It is further postulated that variations in the ability of different aquatic macrophytes to cope with infertility or other factors associated with unfavorable sediment composition may influence the species composition of aquatic macrophyte communities.
Absence of Sex Differential Plasticity to Light Availability during Seed Maturation in Geranium sylvaticum

Sex-differential plasticity (SDP) hypothesis suggests that since hermaphrodites gain fitness through both pollen and seed production they may have evolved a higher degree of plasticity in their reproductive strategy compared to females which achieve fitness only through seed production. SDP may explain the difference in seed production observed between sexes in gynodioecious species in response to resource (nutrients or water) availability. In harsh environments, hermaphrodites decrease seed production whereas females keep it relatively similar regardless of the environmental conditions. Light availability can be also a limiting resource and thus could theoretically affect differently female and hermaphrodite seed output even though this ecological factor has been largely overlooked. We tested whether the two sexes in the gynodioecious species Geranium sylvaticum differ in their tolerance to light limitation during seed maturation in the field. We used a fully factorial block experiment exposing female and hermaphrodite plants to two different light environments (control and shade) after their peak flowering period. Specifically, we measured fruit and seed production in response to decreased light availability and compared it between the sexes. Shading reduced the number of fruits and seeds produced, but the decrease was similar between the sexes. Furthermore, shading delayed seed production by three days in both sexes, but did not affect seed mass, seed P content, or the probability of re-flowering the following year. Our results give no evidence for reproductive SDP in response to light during seed maturation.
POEM: Physical Oceanography of the Eastern Miditerranean

The Mediterranean as a whole communicates with the Atlantic Ocean through the narrow and shallow Gibraltar Strait. In recent years, scientific interest has been focused on the western Mediterranean and the Strait of Gibraltar through the execution of the Western Mediterranean Circulation Experiment [La Violette, 1987] and the 1985–1986 Gibraltar Experiment [Kinder and Bryden, 1987]. These experiments and other, related investigations, however, do not involve the eastern part from the Strait of Sicily to the easternmost Levantine Basin. The most recent phenomenological materials available about this part of the Mediterranean are the studies by Lacombe and Tchernia [1960, 1972]. More recently, El-Gindy and El-Din [1986] produced an analysis of historical oceanographic data available at the Museum National d'Histoire Naturelle in Paris, collected in surveys of the Eastern Mediterranean during 1960—1972. Finally, a general survey of past efforts and investigations has just been written [Malanotte-Rizzoli and Hecht, 1987].
Calibration of Meteosat water vapor channel observations with independent satellite observations

The objective of this study is to identify potential problems of and increase confidence in the operational calibration of the water vapor channel of the Meteosat Visible and Infrared Radiation Imager (MVIRI). First, the operational vicarious calibration method of the MVIRI water vapor channel is analyzed. This is done through a comparison of the operational calibration coefficient with a calibration coefficient derived from collocated satellite observations taken by water-vapor-sensitive channel 12 of the High Resolution Infrared Sounder (HIRS) on NOAA 14. The analysis suggests a relatively large difference between the two calibration coefficients, the operational calibration coefficient being 10–15% larger than the one from the intersatellite calibration. Second, no such difference is found to exist between the MVIRI operational calibration coefficient and an intersatellite calibration coefficient derived from collocated GOES 8 water-vapor-sensitive channel 3 observations. Third, it is shown that the operational calibration coefficient for the MVIRI water vapor channel on Meteosat 7 is consistent with its blackbody calibration. At the present stage of the research no definite conclusions can be made. The results support the previously documented accuracy of 5% for the operational calibration coefficient of the MVIRI water vapor channel.
An analysis of LULC change detection using remotely sensed data; A Case study of Bauchi City

Bauchi is one of the cities in the north eastern part of Nigeria that has witnessed tremendous expansion as a result of rapid urbanization. For the past decade, the city has been known to be relatively small both in size and population. But today, Bauchi is one of the fastest growing cities in northern Nigeria. Therefore, it is paramount to detect the nature and magnitude of these changes in order to determine its direction of future expansion. To achieve that, Remotely Sensed data from Landsat 7 ETM+ and Landsat 8 were utilized for the purpose of LULC change detection in Bauchi city. Landsat 7 image of 2003 and Landsat 8 image of 2013 were obtained for the purpose of the study. Three change detection algorithms were used to detect areas of change. They include supervised, unsupervised and post classification comparison. While the unsupervised classification was found to be less effective, the supervised classification produced good results with overall accuracies of 93.5% and 89.7% for the 2003 and 2013 respectively. Finally, "from-to" change was obtained using the post classification comparism.