Miracle-dz/UniFAR-FTUs huggingface dataset:
Short Communication The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions s

Although the pathophysiology of carbamazepine-induced idiosyncratic or hypersensitivity reactions is unclear, they are presumed to be immune mediated, involving a complex interaction between drug metabolism and activation of the immune system. Cell stress can be caused by reactive metabolites, and this has the potential to release damage-associated molecular patterns (DAMPs), which are responsible for activation of the immune system. Idiosyncratic drug reactionsoccurmainlyintheliverbecauseofitsroleindrugmetabolism and reactive metabolite formation. DAMPs can activate inflammasomes, which may be a common mechanism by which DAMPs lead toanimmuneresponse.Inthepresentstudy,weinvestigatedwhether carbamazepine induces the release of DAMPs by using human hepatocarcinoma functional liver cell-4 (FLC-4) cells for bioactivation of carbamazepine. THP-1 cells, a human macrophage cell line, were used for detecting inflammasome activation. We found that increased caspase-1 activity and production of interleukin-1 b by THP-1 cells were caused by the supernatant from the incubation of carbamazepinewithFLC-4cells. Inthe supernatant,heat shock protein 60 was significantly increased. In addition, 2-hydroxyiminostilbene
Enhancing Performance Of Multi-Cloud Storage Environment Using Modified Erasure Coding Technique

: Cloud services aren't without flaws. Even giants in the cloud, such as Amazon Web Services, have outages. Measures to safeguard data from disruptions should be part of any successful cloud computing strategy. Data Availability in the Cloud refers to the capacity to provide data and services to users regardless of outages or other disasters. Planning for redundancy and data dissemination is the best way to ensure high data availability. Implementing redundancy and data dissemination may be done in a variety of ways. Replication and Erasure Coding Approaches are two of the most often used techniques. Many top cloud storage providers (CSPs) are now using these strategies to avoid data loss and to recover quickly from disk failures. This project focuses on leveraging OpenStack-Swift to create an object storage cloud that uses replica and erasure coding methods to deliver high data availability and efficient storage.
Opleiding Informatica Analyzing ChatGPT’s output: a study on its psycholinguistic dimensions and personality traits

Humans tend to respond similarly in their judgements of words for the psycholinguistic dimensions of typicality and imageability. If ChatGPT answered similar as well, then it would be safe to assume that its judgement of these words are indistinguishable from humans. A personality test was also conducted on ChatGPT to observe whether its answers are stable when asked the same question over a short period of time. This study resulted in differing correlation values for these experiments. Some data output of ChatGPT might be suspicious when compared directly to human data, while other output seems to be highly correlating with human data and would therefore likely not be distinguishable. In reality however, it would be very unlikely to ever truly conclude that certain data was generated by ChatGPT instead of a human. In that sense, it would mean that ChatGPT’s output is indistinguishable from human output.
Investigation on the macrobenthos of artificial reefs area in the Haizhou Gulf

The artificial reef construction of Haizhou Gulf has been carried out for four years,in order to understand the variation of macrobenthos in the gulf aroung casting the reefs,the investigation on the macrobenthos' resources of the gulf has been put into effect.It came to the conclusion that a total of 94 kinds of macrobenthos have been identified,Mollusca,Crustacea and fish were the dominant groups,amounted to 88.3% of th total.There are 32 kinds of macrobenthos before casting the reefs,added up to 38 after casting the reefs for 1 year,to 44 after 4 years later.The average biomass and individual density was 0.560 3 g/m2 and 0.207 5 inds. /m2 before casting the reefs,after casting the reefs for 1 year,the average biomass and individual density was respectively added to 1.127 g/m2 and 0.387 5 inds. /m2.The average biomass and individual density of 2 and 4 years after casting the reefs were more than those of before the casting reefs.Commumity of macrobenthos on artificial reefs in the Haizhou Gulf were relatively stable before casting the reefs,but appeared some disturbance after casting the reefs and situated in the state of temporal fluctuation.
Contagion and Trade: Why are Currency Crises Regional?

Currency crises tend to be regional; they affect countries in geographic proximity. This suggests that patterns of international trade are important in understanding how currency crises spread, above and beyond any macroeconomic phenomena. We provide empirical support for this hypothesis. Using data for five different currency crises (in 1971, 1973, 1992, 1994, and 1997) we show that currency crises affect clusters of countries tied together by international trade. By way of contrast, macroeconomic and financial influences are not closely associated with the cross-country incidence of speculative attacks. We also show that trade linkages help explain cross-country correlations in exchange market pressure during crisis episodes, even after controlling for macroeconomic factors.
Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis

Background and aims: The incidence of irritable bowel syndrome (IBS) or functional bowel disorders (FBD) after bacillary dysentery (BD) has not been extensively evaluated, and little is known of the pathogenesis of post-infective (PI) IBS. Therefore, we investigated the incidence of IBS and FBD in a Chinese patient population who had recovered from BD. To further elucidate its pathogenesis, neuroimmunological changes, including interleukins (IL), mast cells, neuropeptides
Efficacy of Fractionated Erbium Laser in Treating Radiation-Induced Dermal Atrophy: A Case Report

Radiation dermatitis is a common side effect of radiotherapy in patients with acute and chronic changes affecting the skin. While acute changes occur within 90 days of radiation exposure, chronic changes manifest thereafter. This paper presents a case of a 70-year-old male with squamous cell carcinoma in situ (SCCIS) on the right zygoma who was treated with superficial radiation therapy (SRT), which resulted in a hypo-pigmented atrophic scar. The scar was successfully treated with a single session of Erbium:YAG laser therapy. The findings highlight the need for improved treatment options for radiation-induced skin changes and demonstrate the efficacy of fractionated laser therapy in addressing SRT-induced dermal atrophy.
Implications of domestication syndrome in barley for above-and belowground plant traits and microbial interactions

Domestication and intensive management practices have signiﬁcantly shaped characteristics of modern crops. However, our understanding of domestication’s impact had mainly focused on aboveground plant traits, neglecting root and rhizospheric traits, as well as trait-trait interactions and root-microbial interactions. To address this knowledge gap, we grew modern ( Hordeum vulgare L. var. Barke) and wild barley ( H. spontaneum K. Koch var. spontaneum ) in large rhizoboxes. We manipulated soil microbiome by comparing disturbed (sterilized soil inoculum, DSM) versus non-disturbed (non-sterilized inoculum, NSM) microbiome Results showed that modern barley grew faster and increased organic-carbon exudation (OC EXU ) compared to wild barley. Interestingly, both barley species exhibited accelerated root growth and enhanced OC EXU under DSM, indicating their ability to partially compensate and exploit the soil resources independently of microbes if need be. Plant trait network analysis revealed that modern barley had a denser, larger, and less modular network than wild barley indicating domestication’s impact on trait coordination. Further, soil microbiome inﬂuenced speciﬁc network parameters. While the relative abundance of bacteria didn’t vary between wild and modern barley rhizospheres, species-speciﬁc core bacteria were identiﬁed, with stronger eﬀects under DSM. Overall, our ﬁndings highlight domestication-driven shifts in root traits, trait coordination, and their modulation by the soil microbiome.
IN-SERVICE EVALUATION OF MAJOR URBAN ARTERIALS WITH LANDSCAPED MEDIANS— CONDITIONS AS OF 2004

Arterials such as State Route (SR) 99 north and south of Seattle have characteristics that are considered by many cities to be undesirable. In response, several cities are implementing redevelopment plans to increase road safety, create a more aesthetically pleasing local environment, and enhance the economic vitality and attractiveness of the communities. The cities’ redevelopment proposals for SR 99 and other state routes include landscaped medians, many with trees placed close to the roadway in either the median or shoulder areas. However, WSDOT’s clear zone width criterion may not always be met when trees are placed within curbed medians. To address the desires of cities to implement aesthetic designs, WSDOT chose to adopt an in-service evaluation process that would study collision, environmental, operational, and maintenance experiences in the field. This report summarizes the findings of two of the 13 median treatment projects included in the in-service evaluation of alternative median treatments. It provides before data and condition information on all median sections, but because most of the roadway sections have only recently been improved, it provides after data for only two phases of improvements, those on SR 99 in the City of SeaTac. The conclusions of the before and after analysis on those two sections of roadway indicate that no dramatic changes in roadway safety have occurred as a result of the change from continuous two-way left turn lanes and limited sidewalks to a streetscape that includes full sidewalks and landscaped medians with turn pockets, and where both sidewalks and medians include small trees as part of the landscaping. While no definitive conclusions about the safety impacts of landscaped medians can be drawn at this point in the multi-year in-service evaluation, it can be said that there is no indication that the roadways are less safe than before the landscaping was planted. Therefore, it is recommended that the current in-service evaluation be continued as planned.
Developing secure, unified, multi-device, and multi-domain platforms: a case study from the webinos project.

The need for integrated cross-platform systems is growing. Such systems can enrich the user experience, but also lead to greater security and privacy concerns than the sum of their existing components. To provide practical insights and suggest viable solutions for the development, implementation, and deployment of complex cross-domain systems, in this chapter, the authors analyse and critically discuss the security-relevant decisions made developing the Webinos security framework. Webinos is an EU-funded FP7 project, which aims to become a universal Web application platform for enabling development and usage of cross domain applications. Presently, Webinos runs on a number of different devices (e.g. mobile, tables, PC, in-car systems, etc.) and different Operating Systems (e.g. various Linux distributions, different Windows and MacOSx versions, Android 4.x, iOS). Thus, Webinos is a representative example of cross-platform framework, and even if yet at beta level, is presently one of the most mature, as a prototype has been publicly available since February 2012. Distilling the lessons learned in the development of the Webinos public specification and prototype, the authors describe how potential threats and risks are identified and mitigated, and how techniques from user-centred design are used to inform the usability of security decisions made while developing the alpha and beta versions of the platform.
THE ROLE OF IT GOVERNANCE AS MULTIGROUP MODERATION IN THE RELATIONSHIP OF ORGANIZATIONAL DEMOGRAPHICS, EXTERNAL ENVIRONMENT CHARACTERISTICS, AND ORGANIZATIONAL CULTURE TO FRAUD

This study focuses on companies related to fraud and the purpose of this study is to reveal the causal relationship between the influence of exogenous variables, namely Organizational Demography, External Environmental Characteristics, Organizational Culture, and IT Governance as moderating variables to the endogenous variable, namely fraud, so this study uses explanatory research. The population of this study are companies that go public (offering business ownership to the general public) which are listed on the Indonesia Stock Exchange until 2020 and commit fraud in the company's financial reporting or within a certain period of time do not report financial statements, namely 216 companies. The sampling technique used in this study was purposive sampling with the determination of the sample size using the 5% slovin formula. This research uses Structural Equation Modeling (SEM) analysis with Partial Least Square (PLS) method. The result fo this study show that Organizational Demographics does not have a significant positive effect on Fraud; In IT Governance with a low category, External Environmental Characteristics does not have a significant effect in a positive direction on Fraud, but in high category, External Environmental Characteristics have a significant effect in a positive direction on Fraud; and Organizational Culture has a significant negative effect on Fraud. The originality of this research is the disclosure of the impact of the moderating variable of IT Governance on the influence of Organizational Demographics, External Environmental Characteristics, and Organizational Culture on Fraud. In this study, the moderating variable of IT Governance is a categorical variable which is divided into two groups, namely the low group and the high group.
CYBERSECURITY IMPLEMENTATION SUCCESS FACTORS IN SMART CITY

Cybersecurity has proven to be a prominent topic in business and government developments. Although most Smart City organizations have cybersecurity strategies in place, they still face challenges in implementing them. The implementation and adoption of appropriate cybersecurity are challenging and knowledge-intensive and require the participation and support of policymakers and IT units. However, although awareness of critical success factors (CSF) for cybersecurity implementation is very beneficial in avoiding failure in Smart City projects, this area has rarely been researched, especially with a focus on Smart City development. Therefore, the contribution of this paper to research and practice is the identification of critical factors that influence the successful implementation of cybersecurity in smart cities. This study was carried out through an interview study with officials and staff in the Jakarta Smart City environment. As a result, we have 15 keys critical factor that has a practical implementation and could include in the model of cybersecurity in smart cities.
OPTIMIZATION OF PARAMETERS ON SUPPORT VECTOR MACHINES AT VARIOUS FACTOR LEVEL VALUES

The purpose of this study is to optimize the parameters on Support Vector Machines (SVM) at various factor level values and compare the classification results. The data used in this study are secondary data from the 5C (Collateral, Character, Capacity, Condition of economy, and Capital) assessment at Bank X. Optimization of the parameters is carried out by determining each of the 5-factor level values for parameters C and γ. The determination of the 5 factor level values was carried out based on previous research, namely for the value of C = {0.5,0.75,1,10,100} and γ = {0.005,0.05,0.1,0.5,0.75}. The data is divided into two parts, namely training data and testing data with a ratio of 80:20. This comparison is based on the Pareto principle. This division is also done using 5-fold cross-validation. The kernel used in this study is the Kernel Radial Basis Function (RBF) because RBF can transform data into very high dimensions so that it can perform classification well. The conclusion that can be drawn based on this research is by using a kernel trick, especially using the RBF kernel, the results of parameter optimization are better. This is proven by the average level of accuracy using the RBF kernel with cross-validation using 5-fold reaching 90.38% while without the kernel trick it only reaches an average accuracy of 65%. Novelty in this study is the use of the 5C variable in the credit assessment at Bank X and the use of the 5 level factor value for parameter optimization of the SVM.
Clostridium aromaproducens sp. nov., isolated from pit mud used for producing Wuliangye baijiu

A strictly anaerobic, gram-positive bacterium, designated as WLY-B-L2 T , was isolated from pit mud of a fermentation pit located at Wuliangye 501# baijiu workshop in Yibin (Sichuan province, PR China). The strain has straight or somewhat rod-shaped cells, which are 0.5–0.7 µm wide and 1.7–3.1 µm long, arranged singly or in pairs. The strain can produce butyric acid and utilize D-galacturonic acid, methyl pyruvate, L-lactamine, L-alanyl-L-glutamine, L-alanyl-L-histidine, glycerol, pyruvate, L-alanyl-L-threonine, L-methionine, L-phenylalanine, L-valine + L-aspartic acid, L-serine, L-valine, and thymidine as carbon sources. Major cellular fatty acids are C 16: 0 (24.6%), anteiso-C 15: 0 (16.5%), and iso-C 15: 0 (14.1%). Based on 16S rRNA gene sequence, WLY-B-L2 T is most closely related to Clostridium luticellarii FW431 T ; they exhibit 97.42% 16S rRNA similarity. Additionally, the digital DNA-DNA hybridization (dDDH) value between them is 28.10%. WLY-B-L2 T has a G + C content of 34.16 mol%. Based on the evidence presented here, WLY-B-L2 T (CICC 25133 T = JCM 35127 T ) is proposed as the type strain of a novel species, designated as Clostridium aromatiproducens sp. nov.
MIT Open Access Articles Least Squares Temporal Difference Methods: An Analysis under General Conditions

We consider approximate policy evaluation for ﬁnite state and action Markov decision processes (MDP) with the least squares temporal diﬀerence (LSTD) algorithm, LSTD( λ ), in an exploration-enhanced learning context, where policy costs are computed from observations of a Markov chain diﬀerent from the one corresponding to the policy under evaluation. We establish for the discounted cost criterion that LSTD( λ ) converges almost surely under mild, minimal conditions. We also analyze other properties of the iterates involved in the algorithm, including convergence in mean and boundedness. Our analysis draws on theories of both ﬁnite space Markov chains and weak Feller Markov chains on a topological space. Our results can be applied to other temporal diﬀerence algorithms and MDP models. As examples, we give a convergence analysis of a TD( λ ) algorithm and extensions to MDP with compact state and action spaces, as well as a convergence proof of a new LSTD algorithm with state-dependent λ -parameters.
Integrated Use of Organic and Inorganic Source Fertilizers to Improve Yield of Potato and Soil Properties of Nitisols, Central Highlands Ethiopia

: The field experiment was conducted to determine the effect of integrated use of organic and inorganic fertilizers on growth and tuber yield of potato ( Solanum tuberosum L.). The treatment consists of anintegrated use of organic and inorganic source fertilizer. The treatments included ten selected combinations of organic and inorganic nutrient sources, including vermicomposting, compost, nitrogen (N) and phosphorus (P). The design was randomized complete block with three replications. Results showed that potato yield and yield components, were significantly affected by the application of organic and inorganic fertilizer sources. The highest total tuber yield of 32.2 ton ha was obtained from the applications of 75 % Rec NP +25 % vermicompost based on the 1 recommended N equivalent and of the recommended N and P fertilizers, followed by 29.3 ton ha due to the 1 application of the full recommended inorganic N and P fertilizers. The highest marketable tuber yield of 28.5 ton ha was obtained from the applications of 75% recommended NP with 25 % vermicompost based on the 1 recommended N equivalent. Therefore, potato growers can exercises accompanying inorganic fertilizer with organic nutrients is the most suitable opportunity to maximize the production of potato for smallholder farmers to make their food security sustainable.
The influence of basement reactivation on the extensional and inversional history of the Kutai Basin, East Kalimantan, SE Asia

The Kutai basin, East Kalimantan, is one of several large extensional basins formed in the Middle to Late Eocene. Formed above an orogenic complex of Late Cretaceous/Early Tertiary age, basement fabrics oriented NW–SE and NE–SW strongly influenced basin extension and inversion. Remote sensing data and fieldwork show basement fabric on the margins and Tertiary cover are dominated by NE–SW, NW–SE and NNE–SSW-trending structures. Similarly, on a larger scale, NW–SE narrow linear gravity lows cut NNE–SSW highs on the gravity data within the basin. Reconstruction of the basin architecture shows NNE–SSW basin-bounding faults overlapping in a right stepping en-echelon manner. These overlaps (relay ramps) were breached by faults oriented NE–SW through reactivation of the basement fabric. Opposing antithetic and synthetic half-grabens were linked by highly oblique NW-SE transfer faults. Inversion utilized extensional faults as reverse faults; however, NW–SE-oriented structures were reactivated as zones of lateral offset along the fold-thrust belt, whilst fault kinks oriented NE–SW were reactivated as oblique-slip reverse faults. The Kutai Basin provides an example of the controls that basement heterogeneities play on both extension and inversion.
A study on the risk management of the CASA-1000 project

This study aimed at conducting both qualitative and quantitative analyses of the Central Asia South Asia Electricity Transmission and Trade Project (CASA-1000) to obtain risk management information. Consequently, real options were introduced in the form of risk hedges, and we attempted to estimate the hedge cost. Through qualitative analysis we identified the geopolitical risks. We also see that a certain degree of demand risk exists. Therefore, when evaluating project feasibility, it would be better to consider the hedge cost of these risks. Through quantitative analysis, when weighted average cost of capital is ≤10.0% and volatility is below a certain value, a hedge risk based on real options and the introduction of private funds may be possible. Thus, from a risk management viewpoint, it could be suggested that introducing private funds is possible in certain situations.
Statistical significance of the seismic coupling coefficient

Variations in the seismic coupling coefficient (χ), the ratio of the observed to expected seismic moment release rates, at subduction zones are commonly used to make inferences about the physics of subduction. Taking into account the power-law form of the earthquake frequency-moment relation, it is shown that the observed distribution of χ at the world's subduction zones based on the twentieth century's earthquakes can be matched by a single value of χ ≈ 0.3 if, as is likely the case, the 90-yr observation time is less than or comparable to the repeat time of the largest possible earthquake. It is shown that because our reliable earthquake record is short, global variations in χ, based on seismicity alone, are poorly resolved and cannot be used to distinguish among subduction models.