Miracle-dz/UniFAR-FTUs huggingface dataset:
An Agentic Approach to Food Access and Acquisition: The Case of Mixed Neighborhoods in the Paris Metropolis

How do urban residents access and acquire food? Building on the food desert scholarship, I propose an agentic framework and fieldwork in two mixed neighborhoods (one gentrifying, one working-class suburban) in the Paris metropolis. First- and second-generation immigrants perceive the metropolis as a rich and diverse food environment, whereas natives perceive their neighborhood of residence as a food-deficient environment. First- and second-generation immigrants endow mobility with self-efficacy, whereas natives construct proximity as a moral value. First- and second-generation immigrants’ acquisition practices consider price and types of foods and span the metropolis. Those of natives consider types of foods and center on their neighborhood of residence. These findings complicate neighborhood-centric, spatially deterministic approaches to food access and acquisition, by highlighting structural (access to transportation and disposable time and income) and cultural dimensions (judgments and practices). Theoretically, they suggest two distinct ways in which urban residents find meaning in performing mundane activities: believing in self-efficacy and constructing moral values. Additional implications regard social life in gentrifying neighborhoods, space and place in European urban societies, and everyday life and public transportation in the Paris metropolis.
The Z-Disk Final Common Pathway in Cardiomyopathies

The sarcomeres represent the essential contractile units of the cardiac myocyte and are bordered by two Z-lines (disks) that are made by various proteins. The cardiac Z-disk is recognized as one of the nodal points in cardiomyocyte structural organization, mechano-sensation and signal transduction. Rapid progress in molecular and cellular biology has significantly improved the knowledge about pathogenic mechanisms and signaling pathways involved in the development of inherited cardiomyopathies. Genetic insult resulting in expression of mutated proteins that maintain the structure of the heart can perturb cardiac function. The primary mutation in the cardiac contractile apparatus or other subcellular complexes can lead to cardiac pathology on a tissue level, resulting in organ and organism level pathophysiology. The “final common pathway” hypothesis interpreting the genetic basis and molecular mechanisms involved in the development of cardiomyopathies suggests that mutations in cardiac genes encoding proteins with similar structure, function, or location and operating in the same pathway, are responsible for a particular phenotype of cardiomyopathy with unique morpho-histological remodeling of the heart. This chapter will describe genetic abnormalities of cardiac Z-disk and related “final common pathways” that are triggered by a Z-disk genetic insult leading to heart muscle diseases. In addition, animal models carrying mutations in Z-disk proteins will be described.
A Review on Efficacy of Sensors in Capturing Biophysical Measures and its Application in the Field of Physical Therapy and Rehabilitation

Background: Use of sensors for assessment and treating orthopedic and neurological conditions inphysical therapy and rehabilitation is in practice since last 2 decades. Its efficiency has been promising withadvancements in research and clinical practice.Objective: The aim of the present review is to synthesize and evaluate studies which have performed a roleto test efficacy of sensors following orthopedic and neurological conditions for research and clinical practicein physical therapy and rehabilitation.Data Source: Are view of articles identified from high impact journal from Springer, Hindawi, MDPI,PLOSone, De Gruyter was performed by both researchers.Study Eligibility Criteria: Articles published only in English between January, 2010 and December, 2019were included which investigated role of sensors in physical therapy and rehabilitation.Study Appraisal and Synthesis Method: Studies were grouped as wearable, bio-mechanical pressure,motion capture sensing technology and stretch sensors.Results: From the 17 articles identified, 10 papers were involved in the review which was deemed as beingof high quality.Conclusion: Sensor technology is a full-fledged and rapidly growing field with imperative focus andnoteworthy role in assessment and treatment for upper and lower limbs insufficiencies, spinal curvecorrections in numerous orthopedic and neurological conditions. Research over the past 10 years grandlyfocused on the use of sensors in physical therapy and rehabilitation.
Detecção de buracos em pavimento asfáltico com base em Processamento Digital de Imagens e Deep Learning

The road infrastructure conditions are directly related to the safetyand operational cost of transportation. Potholes are defects in thepaving that affect safety on the road. Therefore, identifying potholesis an important step in defining road maintenance and interventionstrategies. Among the approaches used to detect defects in roadsare vibration techniques, laser scanning and 3D reconstruction, andfinally methods that are vision-based. These vision-based methodsutilize image processing, considered low cost and that can be performedby common two-dimensional cameras. This research aimsto combine digital image processing and deep learning concepts facilitatingthe recognition of pothole-like defects in road images withasphalt paving. In order to carry out these experiments, differentnetwork architectures were used.
Anticancer gold(iii)-bisphosphine complex alters the mitochondrial electron transport chain to induce in vivo tumor inhibition

Expanding the chemical diversity of metal complexes provides a robust platform to generate functional bioactive reagents. To access an excellent repository of metal-based compounds for probe/drug discovery, we capitalized on the rich chemistry of gold to create organometallic gold(iii) compounds by ligand tuning. We obtained novel organogold(iii) compounds bearing a 1,2-bis(diphenylphosphino)benzene ligand, providing structural diversity with optimal physiological stability. Biological evaluation of the lead compound AuPhos-89 demonstrates mitochondrial complex I-mediated alteration of the mitochondrial electron transport chain (ETC) to drive respiration and diminish cellular energy in the form of adenosine triphosphate (ATP). Mechanism-of-action efforts, RNA-Seq, quantitative proteomics, and NCI-60 screening reveal a highly potent anticancer agent that modulates mitochondrial ETC. AuPhos-89 inhibits the tumor growth of metastatic triple negative breast cancer and represents a new strategy to study the modulation of mitochondrial respiration for the treatment of aggressive cancer and other disease states where mitochondria play a pivotal role in the pathobiology.
The CatWalk XT® Gait Analysis Is Closely Correlated with Tissue Damage after Cervical Spinal Cord Injury in Rats

Objective and consistent assessment of locomotion recovery remains challenging in rodent spinal cord injury (SCI). We, therefore, studied the validity and relevance of the CatWalk XT® gait analysis as a tool for assessing functional outcome in a clinically relevant cervical SCI model in rats. In total, 20 Wistar rats were randomly assigned to either a C6 clip compression/contusion SCI or a sham laminectomy. Locomotion recovery was assessed weekly using the CatWalk XT® gait analysis and the BBB open field score. Six weeks after SCI, the percentage of preserved spinal cord tissue was measured by glial fibrillary acidic protein (GFAP) immunohistochemistry (IHC) staining. Statistical analyses were performed to assess the correlation of the BBB and the percentage of preserved tissue with 30 different CatWalk XT® parameters. SCI caused a bilateral and significant functional impairment in all studied CatWalk XT® parameters. Similar to the BBB, a significant spontaneous recovery could be observed in most of the CatWalk XT® parameters in the following weeks. Correlation between the hindlimb CatWalk XT® parameters and the BBB was good (53% of r values > 0.6) while the correlation between the forelimb and the hindlimb CatWalk XT® parameters and the percentage of preserved tissue was even stronger (83% of r values > 0.6). The CatWalk XT® gait analysis is closely correlated with tissue damage after cervical contusion/compression SCI and can be used as an objective and consistent tool for assessing locomotion recovery.
Simulating and Building an Appliance Clustering Fuzzified SVC for Single Phase System

A power system suffers from losses that can cause tragic consequences. Reactive power presence in the power system increases system losses delivered power quality and distorted the voltage. As a result, many studies are concerned with reactive power compensation. The necessity of balancing resistive power generation and absorption throughout a power system gave birth to many devices used for reactive power compensation. Static Var Compensators are hunt devices used for the generation or absorption of reactive power as desired. SVCs provide fast and smooth compensation and power factor correction. In this paper, a Fuzzified Static Var Compensator consists of Thyristor Controlled Reactor (TCR) branch and Thyristor Switched Capacitors branches for reactive power compensation and power factor correction at the load side is presented. The system is simulated using Simulink using a group of blocks and equations for measuring power factor, determining the weightage by which the power factor is improved, determining the firing angle of TCR branch, and capacitor configuration of TSC branches. Furthermore, a hardware prototype is designed and implemented with its associated software; it includes a smart meter build-up for power monitoring, which displays voltage, current, real power, reactive power and power factor and SVC branches with TRIAC as the power switching device. Lastly, static and dynamic loads are used to test the system's capability in providing fast response and compensation. The simulation results illustrated the proposed system's capability and responsiveness in compensating the reactive power and correcting the power factor. It also highlighted the proportional relation between reactive power presence and the increased cost in electricity bills. The proposed smart meter and SVC prototypes proved their capabilities in giving accurate measurement and monitoring and sending the data to the graphical user interface through ZigBee communication and power factor correction. Reactive power presence is an undesired event that affects the equipment and connected consumers of a power system. Therefore, fast and smooth compensation for reactive power became a matter of concern to utility companies, power consumers and manufacturers. Therefore, the use of compensating devices is of much importance as they can increase power capacity, regulate the voltage and improve the power system performance.
Hybrid Energy Routing Approach for Energy Internet

The Energy Internet (EI) has been proposed as an evolution of the power system in order to improve its efficiency in terms of energy generation, transmission and consumption. It aims to make the use of renewable energy effective. Herein, the energy router has been considered the crucial element that builds the net structure between the different EI components by connecting and controlling the bidirectional power and data flow. The increased use of renewable energy sources in EI has contributed to the creation of a new competitive energy trading market known as peer-to-peer energy trading, which enables each component to be part of the trading process. As a consequence, the concept of energy routing is increasingly relevant. In fact, there are three issues that need to be taken into account during the energy routing process: the subscriber matching, the energy-efficient path and the transmission scheduling. In this work, we first proposed a peer-to-peer energy trading scheme to ensure a controllable and reliable EI. Then, we introduced a new energy routing approach to address the three routing issues. A subscriber matching mechanism is designed to determine which producer/producers should be assigned for each consumer by optimizing the energy cost and transmission losses. This mechanism provides a solution for both mono and multi-source consumers. An improved ant colony optimization-based energy routing protocol was developed to determine a non-congestion minimum loss path. For the multi-source consumer case, an energy particle swarm optimization algorithm was proposed to choose a set of producers and to decide the amount of energy that should be collected from each producer to satisfy the consumer request. Finally, the performance of the proposed protocol, in terms of power losses, cost and computation time was compared to the best existing algorithms in the literature. Simulation results show the effectiveness of the proposed approach.
Um Estudo de Caso de Avaliação de Acessibilidade de Documentos PDF de um Ambiente Virtual de Aprendizagem

Virtual learning environments are commonly adopted by universitiesas classroom teaching support. One of the resources they offerare class presentations, usually in PDF files. Considering that webaccessibility is essential to allow users with some limitations tounderstand, interact, operate and navigate web content, this articlepresents an assessment of the accessibility of PDF documents madeavailable on Moodle. The methodology used a hybrid approachcomprised techniques and practices for assessing human-computerinteraction and assessing accessibility with users simulating blindness.A quantitative analysis of the data was carried out consideringthe accessibility problems faced by users in elements such as tables,graphs, mathematical formulas, expressions in foreign languagesand presentation topics. The results indicated accessibility problemsin all documents in the sample, even causing users to drop outduring the evaluations.
Cholesterol Derivatives as Promising Anticancer Agents in Glioblastoma Metabolic Therapy

ABSTRACT Malignant brain tumors are among the most devastating types of cancer. Glioblastoma is the most common and serious form of brain cancer. Most glioblastomas are surgically unresectable and are typically diagnosed at an advanced stage. The high level of resistance to chemotherapy, radiotherapy and immunotherapy makes glioblastoma one of the most difficult cancers to treat. In brain tumors, the challenges of targeted therapy also include the blood-brain barrier, which often contributes to treatment failure. Therefore, developments of new treatment strategies are required. Metabolic treatments could be an alternative to conventional therapies. Metabolic approaches aim at suppressing glioblastoma tumorigenicity leading to glioblastoma cell death. Since cholesterol metabolism is deregulated in these tumors, this is a promising potential target for therapy. As glioblastoma cells draw on cholesterol from the central nervous system to survive, their growth is theoretically unlimited. Targeting the metabolism of cholesterol by different strategies using, among others, targets of LXRs (Liver X Receptors) or toxic cholesterol analogues could potentially oppose the growth of glial tumors. This chapter discusses the potential of targeting cholesterol metabolism using cholesterol derivatives as a pharmacological alternative to current therapeutic strategy.
Thermal-humidity exposure and water deprivation alter the immune response, and hair but not plasma mineral profiles, in Holstein dairy cows

ABSTRACT In this study, we aimed to determine the effects of thermal-humidity exposure (THE) and water deprivation on the immune response, and hair and plasma mineral profiles of lactating Holstein cows. Thirty multiparous lactating Holstein cows were divided into two groups of 15 cows each: a treatment (T) group subjected to THE and water deprivation for 2 h following feeding, and a control (C) group subjected to THE but with free access to water. Higher levels of sodium (Na), potassium (K), and copper (Cu) in hair were observed in the C group, whereas higher levels of magnesium (Mg), phosphorus (P), calcium (Ca), manganese (Mn), and iron (Fe) in hair were observed in the PC group compared to the other groups. In plasma, mineral contents did not differ between the C and T groups. Additionally, water deprivation during THE decreased hair Mg content. Neutrophil levels and neutrophil/lymphocyte ratios were higher in the T group than in the C group at day 50, but did not differ between the two groups at day 60. Overall, the combination of THE with water deprivation for 2 h altered the hair mineral content, and decreased the immune response, in high-yielding lactating cows.
Credibility Verification of Social Media Users for Detecting Fake News

Fake news contains wrong information’s and mostly it spreads through social media. This is mostly done to impose some ideas and is implemented with reasons. These news containing false claims, may end up with viralized. The role of coordinated users in social media is high as they try to give fake reviews to promote or remove some YouTube videos. These coordinated users also can promote unworthy products for sale. With respect to politics, they can even change the scenario by giving negative votes. This paper implemented to verify the user credibility in social media based on their similarity measures. If the user is incredible then the content posted by them is also assumed to be incredible. It is time consuming and includes lot of difficulty in verifying fake content in social media. So we have tried to segregate incredible users that indirectly helps us to identify fake content posted by them.
Selected Respiratory Protective Devices: Respirators and Significance of Some Markings

Currently, setting the obligation to use respiratory protective equipment with a level of protection of at least FFP2 in public transport and commercial and shopping centers are considered within the European Union. Many new products appeared on the European market within these specifications, and many symbols have been used. The paper deals with the meaning of selected respiratory protection based on respirators symbols and markings (which appeared massively, especially after the pandemic situation in the spring of 2020), these symbols not being uniformly understood and well communicated. We also mention and discuss some of the problems related to setting the conditions of public procurement, which affect respirators. Thus, this review is an “informative guide” in facilitating the understanding and use of full knowledge of the most appropriate respiratory protective devices in various situations.
The Spanish Energy Transition into the EU Green Deal: Alignments and Paradoxes

Climate change, clean energy transition, the energy security quest, and international relations have triggered the revival of renewable energy as a solution to these problems. Nowadays, there is an energy transition where renewable energies bring geopolitical changes in a world where fossil fuels are becoming less relevant. This article aims to assess how the transition influences Spain’s energy relations with other countries regarding electricity and its sources, in alignment with the European Green Deal. In order to do so, its current energy situation, the renewable energies development and its energy import-export relations are examined. The results show that despite progress in green regionalization through more electric interconnection, little difference is to be found in traditional relations with fossil fuel countries exporters, but more are the contractions in Spanish energy economic policy, as here is explained.
A Word-Level Analytical Approach for Identifying Malicious Domain Names Caused by Dictionary-Based DGA Malware

Computer networks are facing serious threats from the emergence of malware with sophisticated DGAs (Domain Generation Algorithms). This type of DGA malware dynamically generates domain names by concatenating words from dictionaries for evading detection. In this paper, we propose an approach for identifying the callback communications of such dictionary-based DGA malware by analyzing their domain names at the word level. This approach is based on the following observations: These malware families use their own dictionaries and algorithms to generate domain names, and accordingly, the word usages of malware-generated domains are distinctly different from those of human-generated domains. Our evaluation indicates that the proposed approach is capable of achieving accuracy, recall, and precision as high as 0.9989, 0.9977, and 0.9869, respectively, when used with labeled datasets. We also clarify the functional differences between our approach and other published methods via qualitative comparisons. Taken together, these results suggest that malware-infected machines can be identified and removed from networks using DNS queries for detected malicious domain names as triggers. Our approach contributes to dramatically improving network security by providing a technique to address various types of malware encroachment.
C60 and C70 pressure-and-temperature transformations into fullerene-related forms

ABSTRACT A two-stage pressure-and-temperature treatment of the C60 and C70 fullerites was carried out. C60 and C70 molecules collapsed at the first-stage hot-isostatic-pressing (HIP; 220 MPa, argon) and transformed into some fullerene-related form in the 900–1750°C temperature range. These materials were used at the second stage of the high-pressure-high-temperature (HPHT; 7.7 GPa/1400°C) treatment to produce the bulk samples that had: a specific weight of about 2.0 g/cm3, 40/110 GPa Young modulus, 6.0/12.5 GPa, and elastic recovery above 81%. Transformations under the treatments were investigated with the X-ray and transmission electron microscopy techniques. The mechanism of the pressure-and-temperature transformations is discussed.
Clinical outcomes of low-dose and high-dose postoperative radioiodine therapy in intermediate-risk papillary thyroid carcinoma patients with low postoperative stimulated thyroglobulin (1-20 ng/ml) and non-structural or functional metastasis: study protocol for a randomized-controlled trial

Background: For some intermediate risk papillary thyroid carcinoma patients, if there are structural metastases, reoperation is preferred. If there are functional metastases (131I avidity), they can be treated with high-dose radioactive iodine (131I). However, it is still controversial whether 131I ablation should be used and the determination of 131I dosage for another part of intermediate risk patients with non-structural or functional metastases, especially those with postoperative stimulated thyroglobulin (ps-Tg) 1-20 ng/ml. The aim of the present study is mainly to compare the 3-years disease-free survival between low-dose group (1.1 GBq) and high-dose group (3.7 GBq) in intermediate risk papillary thyroid carcinoma patients with non-structural or functional metastases and ps-Tg 1-20 ng/ml.Methods: A single-center, randomized, double-blind parallel controlled study is designed at the Zhujiang Hospital of Southern Medical University. Participants will be randomized to low-dose group (1.1 GBq) or high-dose group (3.7 GBq) in a 1:1 ratio. After orally receiving different dosage of 131I once on an empty stomach, all patients will return to our hospital every 3-12 months to be performed related inspection items. Discussion: We believe that the 3-year disease-free survival of low-dose group (1.1 GBq) may not be lower than that of high-dose group (3.7 GBq) in intermediate-risk thyroid papillary carcinoma patients with no structural or functional metastases and ps-Tg 1-20 ng/ml. Besides we expect to clarify whether there are apparent differences in successful remnant ablation, efficacy, progression-free survival, safety, and health economics evaluation between the two groups.Trial registration: ClinicalTrials.gov (https://clinicaltrials.gov/), ID: NCT04354324. Registered on 16 April, 2020.