Miracle-dz/UniFAR-FTUs huggingface dataset:
Hematological parameters of type 2 diabetic adult patients at Debre Berhan Referral Hospital, Northeast Ethiopia: A comparative cross-sectional study

Background Diabetes is a global public health problem and associated with metabolic, cellular, and blood disturbances. Hematological changes have been reported in diabetes and play a major role in diabetes-associated complications. However, reports are contradicting and data on hematological parameters of type 2 diabetic patients in the study area are scarce. Therefore, the aim of this study was to assess the hematological parameters of type 2 diabetic adult patients at Debre Berhan Referral Hospital, Northeast Ethiopia from May 01 to June 30, 2020. Methods A comparative cross-sectional study was conducted on 268 (134 type 2 diabetic patients and 134 controls) study participants selected by systematic random sampling technique. Socio-demographic, behavioral, and clinical data were collected using a structured questionnaire and checklist. Ethical approval was obtained from Jimma University. All phase of quality assurance was maintained. Hematological parameters and blood glucose levels were determined using UniCel DxH 800 (Beckman Coulter, USA) and Biosystems A25 (Costa Brava, Spain) analyzers, respectively. Independent t-test, Mann–Whitney U-test, correlation, and logistic regression were used during data analysis. P-value <0.05 was considered as statistically significant. Results The current study found that total white blood cell count, absolute counts of neutrophil, lymphocyte, eosinophil, and basophil, red blood cell distribution width, platelet count, and mean platelet volume were significantly higher in type 2 diabetic patients as compared to the control group (P<0.05). On the other hand, the mean hemoglobin was significantly lower in type 2 diabetic patients than the control group (P = 0.007). Anemia was found in 17.9% of type 2 diabetic patients. Longer duration of diabetes (AOR = 3.05, 95% CI = 1.12–8.34) and milk consumption (AOR = 4.60, 95% CI = 1.50–14.00) were significantly associated with anemia. Conclusion This study showed a statistically significant variation in some hematological parameters of type 2 diabetic patients compared to control group. Anemia among type 2 diabetic patients was found to be a mild public health problem. Therefore, routine screening of hematological parameters should be considered for proper management of type 2 diabetic patients. Close attention should also be given to the duration of diabetes and dietary practice.
Evaluating the Aromatherapy Recommendation for Pain in the Holistic Nurses' Pain Relief Tools for Patients and Self-Care

Purpose of Study: The purpose of the study was to evaluate the usefulness of the aromatherapy (AT) recommendation in the American Holistic Nurses Association's (AHNA’s) Holistic Nurses' Pain Relief Tools for Patients and Self-Care (Pain Tool). Methodology: An observational survey design was used and a purposeful sample of 55 nurses were invited to a two-part, 15-question survey administered via SurveyMonkey. The demographic data were analyzed with quantitative analysis and the open-ended questions were analyzed via content analysis. Results: A total of 55 registered nurses completed the survey and the mean age of participants was 53 years old. Lavender essential oil (EO) was used by 100% (N = 55) of participants and the inhalation method was favored (93%; n = 51). The AT recommendation was most helpful for educational purposes (29%; n = 16) and to reduce symptoms of pain (21%; n = 8). A majority of participants used the five holistic nursing core values (70%; n = 31) as well as promote more options for pain management (48%; n = 13) to improve outcomes (30%; n = 13). Respondents recommend the addition of more EOs and safety information (23%; n = 8). Finally, five recommendations were made to AHNA. Implication for Practice: Nurses who use AT (guideline) as a safe, cost-effective intervention for pain improve quality outcomes.
Patients with heart failure and an implanted cardioverter-defibrillator during the COVID-19 pandemic: insights from a multicentre registry in Poland.

3 Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Silesian Center for Heart Diseases, Zabrze, Poland Department of Electrocardiology, Medical University of Lodz, Łódź, Poland Department of Arrhythmia Institute of Cardiology, Warszawa, Poland 1 Department of Cardiology, Doctoral School, Medical University of Warsaw, Warszawa, Poland Cardinal Stefan Wyszynski University in Warsaw, Warszawa, Poland Department of Cardiology, Congenital Heart Diseases and Electrotherapy, Silesian Center for Heart Diseases, Zabrze, Poland 1 Chair and Department of Cardiology, Medical University of Warsaw, Warszawa, Poland Cardiology Department with the Acute Coronary Syndromes Subdivision, Clinical Provincial Hospital No. 2, Faculty of Medicine, University of Rzeszow, Rzeszów, Poland 1 Department of Cardiology, Poznan University of Medical Sciences, Poznań, Poland Computer Science Laboratory, Silesian Center for Heart Diseases, Zabrze, Poland Department of Dietetics, School of Public Health in Bytom, Medical University of Silesia, Katowice, Poland
The epidemiology of bacterial zoonoses in pastoral and dairy cattle in Cameroon, Central Africa

Previous work identified that bacterial zoonoses (Brucella species, Coxiella burnetii and Leptospira hardjo) were present in Cameroonian pastoral cattle. To assess the characteristics of this zoonotic risk, we analyse seroprevalence of each pathogen and the associated management, herd and environmental factors in Cameroonian pastoral and dairy cattle. Cross‐sectional samples included pastoralist herds in the Northwest Region (NWR n = 750) and Vina Division (VD n = 748) and small holder dairy herds in the NWR (n = 60). Exposure to Brucella spp. , C. burnetii and L. hardjo were screened for using commercial ELISAs and population adjusted estimates made. In addition, individual, herd and ecological metadata were collected and used to identify risk factors associated with animal‐level seropositivity. In the pastoral cattle, seroprevalence to Brucella spp. was relatively low but was higher in the NWR (4.2%, CI: 2.5%–7.0%) than the VD (1.1%: CI 0.5%–2.4%), while L. hardjo seroprevalence was much higher though similar in the NWR (30.7%, CI 26.3%–35.5%) and VD (35.9%, CI 31.3%–40.7%). No differences were noted in C. burnetii seroprevalence between the two study sites (NWR: 14.6%, CI 11.8%–18.0%. VD: 12.4%, 9.6%–15.9%). Compared to pastoral, dairy cattle had lower seroprevalences for L. hardjo (1.7%, CI: 0.0%–4.9%), C. burnetii (0.0%, CI 0.0%–6.0%) but similar for Brucella spp. (5.0%, CI 0.0%–10.6%). Increased odds of Brucella spp. seropositivity were associated with owning sheep or rearing sheep and fencing cattle in at night. Adult cattle had increased odds of being seropositive for both C. burnetii and L. hardjo. Additionally, exposure to C. burnetii was associated with local ecological conditions and L. hardjo was negatively associated with cattle undertaking transhumance. This work highlights that exposure to these 3 important production diseases and occupational zoonoses are widespread in Cameroonian cattle. Further work is required to understand transmission dynamics between humans and livestock to inform implementation of effective control measures.
Continuous hemadsorption with cytokine adsorber for severe COVID-19: A case series of 15 patients

Background: Hyperinflammation and cytokine release has been associated with severe Covid-19. Hemadsorption cartridges may have a potential role in treatment of cytokine storm associated with the development of severe Covid-19. Methods: We retrospectively examined the case records of patients with severe Covid-19 receiving adjunctive hemadsorption (HA) in our ICU. We analyzed inflammatory biomarkers pre- and post- HA. Results: Fifteen patients received HA during the study period. All were intubated, ventilated and required renal replacement therapy. 11/15 were supported on ECMO. Mean ferritin 2652 (±3286) ng/ml, mean CRP 154 (±92) mg/ml, median D-dimer 3071 (±2689) ng/ml, mean troponin 236 (±461) ng/L. We found significant difference in pre-and post- treatment ferritin 3622 ng/ml versus 1682 ng/ml (p = 0.022), CRP 222 mg/ml versus 103 mg/ml (p = 0.008, 95% CI 22.4–126.5), lactate 2 mmol/L versus 1.3 mmol/L (p = 0.017), and procalcitonin 15.3 ng/ml versus 4.2 ng/ml (p = 0.023). No significant difference in pre- and post- treatment IL-6 14 pg/ml versus 43 pg/ml (p = 0.32), IL-10 3.4 pg/ml versus 2.6 pg/ml (p = 0.31), IL1 β 0.37 pg/ml versus 0.77 pg/ml (p = 0.75), TNF α 12.77 pg/ml versus 12.49 pg/ml (p = 0.75), VIS 10.04 versus 6.01 (p = 0.31, 95% CI 5.98–17.16) was seen. Conclusions: The use of HA as adjunctive treatment in a critically unwell group of COVID-19 patients lead to a reduction in ferritin, CRP, procalcitonin and lactate with no significant change in other parameters. The use of HA in the treatment of severe COVID-19 requires further larger randomized studies.
Implementation of iPads to Increase Compliance With Delivery of New Parent Education in the Mother–Baby Unit: Retrospective Study

Background Abusive head trauma (AHT) is a serious health problem affecting more than 3000 infants annually in the United States. The American Academy of Pediatrics and the Centers for Disease Control and Prevention (CDC) recommend that health care providers counsel new parents about the dangers of AHT. Previous studies demonstrate that parental education is effective at reducing AHT events. South Carolina law requires hospitals to offer all new parents with the opportunity to watch an educational video about AHT. This mandate is addressed in different ways at the several delivery centers within a large South Carolina health care system with a range of viewing methods utilized, from DVD players to mobile workstations to personal devices. Frequent technical barriers and workflow inefficiencies resulted in low rates of compliance with this mandate at several campuses. To improve compliance of parent viewing of this educational video, the health care system standardized video viewing protocol across all campuses by implementing the use of iPads for parental education. Existing literature suggests that patient education can be improved in the hospital setting by utilizing tablet computers, but our literature search identified a gap in research around the education of parents and caregivers during hospitalization for childbirth. We used the implementation of an iPad-based parental education delivery protocol to evaluate whether tablet computers can improve compliance with delivering new parent education in the hospital setting. Objective The objective of this study was to evaluate whether the standardized use of iPads to deliver education in the mother–baby unit resulted in improved rates of parents’ acceptance of the opportunity to view an educational video about AHT. Methods We interviewed physicians and nurses to determine what previous protocols were in place to educate new parents before a standardized iPad-based protocol was implemented across 6 campuses of a large South Carolina health care system. A retrospective study was conducted by review of 5231 records from across the 6 campuses to determine the pre- and postintervention compliance rates of viewing the AHT educational video by parents in the mother–baby unit. Results Compliance increased overall (P<.001) across sites from an average of 41.93% (SD 46.24) to 99.73% (SD 0.26) (φ=0.510). As much as 4 of 6 locations saw a significant increase in compliance rates after introducing the iPad intervention (P<.001). The remaining 2 locations that showed no significant difference (P>.05) had very high rates of preintervention compliance. Conclusions Following the implementation of a standardized iPad-based protocol to deliver new parent education, there was a significant improvement in the percentage of new parents who viewed an educational video about AHT in the mother–baby unit. Based on these results, other health care providers should consider iPads to be a feasible and effective method for delivering hospital-based education to families in the mother–baby unit.
Clinical utility of the ECLECTIC framework in providing culturally-informed autism spectrum disorder evaluations: A pediatric case-based approach

Abstract Objective: Social cognition does not exist within a vacuum. One’s culture and surrounding social environment influence 1) development of social skills and behaviors, and 2) society’s expectations regarding “normal” behavior versus behaviors consistent with the diagnosis of Autism Spectrum Disorder (ASD). Use of a comprehensive cultural framework such as Fujii’s ECLECTIC model undergirds valid ASD testing by enhancing clinician awareness of potential biases during clinical decision-making and by supporting culturally relevant recommendations. Method: Four diverse pediatric patients presenting for concerns of ASD are described. Neuropsychological test data and salient cultural considerations are presented within the ECLECTIC framework. Results: The cases illustrate relevant cultural factors critical to the ASD assessment for youth with wide diversity (Southeast Asian, Deaf, Black, Hispanic/Latinx, and Chinese cultures) and varied contextual factors (adoption, underlying Down syndrome). The ECLETIC model better allows integration of salient factors such as cognition, family dynamics, behaviors, educational services, and language dominance. Conclusions: Unrecognized ethnocentric biases may shadow the complexities and nuances involved in ASD assessment across cultures. Such errors are minimized using a comprehensive cultural framework to guide equitable neuropsychological services. The ECLECTIC model’s emphasis on cultural and contextual factors results in more accurate findings and more individualized planning for the patient. Recommendations for clinical application are provided.
Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets.

Tuberculosis (TB) is a persistent global pandemic and standard treatment has not changed for thirty years. Mycobacterium tuberculosis (Mtb) has undergone prolonged co-evolution with humans, and patients can control Mtb even after extensive infection, demonstrating the fine balance between protective and pathological host responses within infected granulomas. We hypothesised that whole transcriptome analysis of human TB granulomas isolated by laser capture microdissection could identify therapeutic targets, and that comparison with a non-infectious granulomatous disease, sarcoidosis, would identify disease-specific pathological mechanisms. Bioinformatic analysis of RNAseq data identified numerous shared pathways between TB and sarcoidosis lymph nodes, and also specific clusters demonstrating TB results from a dysregulated inflammatory immune response. To translate these insights, we compared three primary human cell culture models at the whole transcriptome level, and demonstrated that the 3D collagen granuloma model most closely reflected human TB disease. We investigated shared signaling pathways with human disease and identified twelve intracellular enzymes as potential therapeutic targets. Sphingosine kinase 1 inhibition controlled Mtb growth, concurrently reducing intracellular pH in infected monocytes and suppressing inflammatory mediator secretion. Immunohistochemical staining confirmed that sphingosine kinase 1 is expressed in human lung TB granulomas, and therefore represents a host therapeutic target to improve TB outcomes.
’ s repository of research publications and other research outputs The “ new industrial man ” as un-hero : doing postfeminist masculinities in an Italian pharmacological research centre Journal Item

Recent work has documented the need to engage with how men construct masculinities within postfeminist discourses in the workplace. Postfeminism has sparked debates concerning the changing ideals of masculinities, highlighting the tensions between traditional forms of patriarchy and “new” ways of being a man (e.g. emotional, a “new father”, in crisis). Men have been depicted as being in search of a new identity, opposed to the ever-growing confidence and empowerment of women. In mobilising postfeminism as a discourse, this article extends existing theorisations of masculinities by showing how men working in an Italian pharmacological research centre assume subject positions that contradictorily fluctuate between tradition and fluid modernity, to reveal a masculinity that we identify with “the new industrial man”. These postfeminist masculinities mesh proand anti-feminist ideas by appealing to un/heroic subjectivities. In discussing the empirical analysis of this organisation, managed by men but dominated by women, we also show how the few men seemed threatened by women’s presence and used biological differences to reinforce social ones and devalue the feminine. The postfeminist subject positions mobilised by these men romanticize men’s masculine heroics, but overlook the evident gender inequalities in the organisation, also characterised by women’s absence from top managerial positions.
Juvenile ecology drives adult morphology in two insect orders

Most animals undergo ecological niche shifts between distinct life phases, but such shifts can result in adaptive conflicts of phenotypic traits. Metamorphosis can reduce these conflicts by breaking up trait correlations, allowing each life phase to independently adapt to its ecological niche. This process is called adaptive decoupling. It is, however, yet unknown to what extent adaptive decoupling is realized on a macroevolutionary scale in hemimetabolous insects and if the degree of adaptive decoupling is correlated with the strength of ontogenetic niche shifts. It is also unclear whether the degree of adaptive decoupling is correlated with phenotypic disparity. Here, we quantify nymphal and adult trait correlations in 219 species across the whole phylogeny of earwigs and stoneflies to test whether juvenile and adult traits are decoupled from each other. We demonstrate that adult head morphology is largely driven by nymphal ecology, and that adult head shape disparity has increased with stronger ontogenetic niche shifts in some stonefly lineages. Our findings implicate that the hemimetabolan metamorphosis in earwigs and stoneflies does not allow for high degrees of adaptive decoupling, and that high phenotypic disparity can even be realized when the evolution of distinct life phases is coupled.
Ecological and evolutionary significance of primates' most consumed plant families

Angiosperms have been essential components of primate diets for millions of years, but the relative importance of different angiosperm families remains unclear. Here, we assess the contribution and ecological and evolutionary significance of plant families to diets of wild primates by compiling an unprecedented dataset of almost 9000 dietary records from 141 primary sources covering 112 primate species. Of the 205 angiosperm plant families recorded in primate diets, only 10 were consumed by more than half of primate species. Plants of the Moraceae and Fabaceae families were the most widely and frequently consumed, and they likely represent keystone resources for primates. Over 75% of species fed on these two families, and together they made up a median of approximately 13% of primate diets. By analysing the relative proportion of different plant parts consumed, we found that Moraceae was mainly eaten as fruit and Fabaceae as non-fruit parts, with the consumption of these two families not showing a significant phylogenetic signal across primate species. Moraceae consumption was associated with small home range sizes, even though more frugivorous primates tended to have larger home ranges compared to more folivorous species, possibly due to the year-round availability of moraceous fruits and the asynchrony in their phenology. Our results suggest that primates may be intricately and subtly shaped by the plant families that they have consumed over millions of years, and highlight the importance of detailed dietary studies to better understand primate ecology and evolution.
Programmable Per-Packet Network Telemetry: From Wire to Kafka at Scale

Efficient and secure management of networks requires collecting and analyzing fine-grained telemetry data, preferably in real-time. Existing monitoring and analysis frameworks (e.g., Netflow, SNMP counters) do not provide fine-grained, per-packet information, are hard or not possible to customize, and do not provide an expressive programming interface to extract information. We present ESnet High Touch Services, a programmable, scalable, and expressive hardware and software solution that produces and analyzes per-packet telemetry information with nanosecond-accurate timing. We highlight our architecture, the most critical performance considerations that allow the processing of 10.4 million telemetry packets per second with only 5 CPU cores, which is more than enough to handle 127 Gbit/s of original traffic with 1512B MTU. We also present applications of the system that use real-time stream processing with elegant filtering, aggregation, and windowing functionalities. Our use-cases show that High Touch Services can support a variety of advanced performance monitoring, troubleshooting, and security tasks.
Doctoral Symposium: Accelerating the Performance of Data Analytics using Network-centric Processing

Distributed execution of real-time data analytics such as event stream processing is the key to scalability, performance and reliable detection of situation changes. Although real-time analytics is highly I/O centric, existing methods supporting the efficient execution of data analytics functions mostly rely on traditional compute models that are available in data centers, e.g., CPU or GPU based processing models, but treat the network mainly as a blackbox. However, with recent advances in software-defined networking (SDN) and the standardization of packet processing pipeline, data analytics functions can be offloaded to programmable switches and benefit from hardware acceleration in an easier and more flexible way than a decade ago. In this paper we focus on the potential of in-network processing to enhance the performance of the overall real-time data analytics application. We aim to contribute to an (i) understanding on how in-network processing can accelerate real-time data analytics and (ii) assess what models of in-network computing can accelerate which event processing functions considering the limitations of network models compared to traditional compute models. We motivate the potential and illustrate the research problems in the context of load balancing which is an important concept in the data-parallel execution of event processing systems.