Miracle-dz/UniFAR-FTUs huggingface dataset:
The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding

Mitochondria are complex organelles that play a central role in metabolism. Dynamic membrane-associated processes regulate mitochondrial morphology and bioenergetics in response to cellular demand. In tumor cells, metabolic reprogramming requires active mitochondrial metabolism for providing key metabolites and building blocks for tumor growth and rapid proliferation. To counter this, the mitochondrial serine beta-lactamase-like protein (LACTB) alters mitochondrial lipid metabolism and potently inhibits the proliferation of a variety of tumor cells. Mammalian LACTB is localized in the mitochondrial intermembrane space, where it assembles into filaments to regulate the efficiency of essential metabolic processes. However, the structural basis of LACTB polymerization and regulation remains incompletely understood. Here, we describe how human LACTB self-assembles into micron-scale filaments that increase their catalytic activity. The electron cryo-microscopy (cryoEM) structure defines the mechanism of assembly and reveals how highly ordered filament bundles stabilize the active state of the enzyme. We identify and characterize residues that are located at the filament-forming interface, and further show that mutations that disrupt filamentation reduce enzyme activity. Furthermore, our results provide evidence that LACTB filaments can bind lipid membranes. These data reveal the detailed molecular organization and polymerization-based regulation of human LACTB and provide new insights into the mechanism of mitochondrial membrane organization that modulates lipid metabolism.
Klasifikasi Sentimen Masyarakat Terhadap Pemerintah Terkait Penerapan Kebijakan New Normal Menggunakan Metode K-Nearest Neighbor

Abstrak - Instagram memiliki berbagai macam pengguna tanpa terkecuali pemerintah, akun instagram pemerintah sendiri memiliki fungsi sebagai salah satu media informasi bagi masyarakat untuk mengetahui berita terbaru. Pemerintah telah melakukan berbagai upaya untuk mengurangi dan memutus rantai penyebaran virus covid-19, salah satu langkah yang diambil pemerintah dalam menghadapi covid-19 dengan menerapkan kebijakan New Normal. Tujuan penulis dari penelitian ini adalah untuk menghitung akurasi metode K-Nearest Neighbor pada klasifikasikan sentimen dari opini masyarakat terkait penerapan kebijakan new normal. Penelitian ini dilakukan melalui beberapa tahapan yaitu pengumpulan data dari akun yang dikelola pemerintah. Setelah itudata tersebut dilakukan proses preprocessing. Lalu membuat model dengan menggunakan word embedding FastText. Selanjutnya menggunakan feature engineering dalam melakukan improve untuk menghasilkan fitur terbaik. Dataset dalam penelitian ini berjumlah 4717 data yang terbagi dari 1456 data kelas pro, 1662 data kelas netral, 1599 data kelas kontra. Pengujian yang dilakukan menggunakan confusion matrix dengan cara menguji data latih dan data uji sebanyak 3 kali dengan perbandingan data 90:10 yaitu nilai akurasi sebesar 60,169% dan pada k-40 dengan perbandingan 80:20 yaitu nilai akurasi 60,16%, sedangkan akurasi terendah terdapat pada perbandingan data 70:30 yaitu 58,12%. Kata kunci: New Normal, Instagram, Klasifikasi, Sentimen, K-Nearest Neighbor Abstract - Instagram has various kinds of users without the exception of the government, the government's own Instagram account has a function as a medium of information for the public to find out the latest news. The government has made various efforts to reduce and break the chain of the spread of the COVID-19 virus, one of the steps taken by the government in dealing with COVID-19 by implementing the New Normal policy. The author's aim of this study is to calculate the accuracy of the K-Nearest Neighbor method in classifying sentiments from public opinion regarding the implementation of the new normal policy. This research was conducted through several stages, namely collecting data from accounts managed by the government. After that, the data is preprocessed. Then create a model using word embedding FastText. Then use feature engineering to improve to produce the best features. The dataset in this study amounted to 4717 data which was divided into 1456 pro class data, 1662 neutral class data, 1599 contra class data. The test was carried out using a confusion matrix by testing training data and test data 3 times with a data comparison of 90:10, namely the accuracy value of 60.169% and at k-40 with a ratio of 80:20, namely the accuracy value of 60.16%, while the lowest accuracy there is a comparison of 70:30 data that is 58.12%. Keywords: New Normal, Instagram, Classification, Sentiment, K-Nearest Neighbor
Effect of low thermal conductivity wick on the performance of compact loop heat pipe

The existing work deals with the evaluation of compact loop heat pipe by means of a low thermal conductivity sintered chrysotile wick to avoid large heat leaks as of the evaporator to the compensation chamber. Accordingly, a wick with low thermal conductivity (0.068–0.098 W/mK) chrysotile powder of a mean particle diameter of 3.4 μm is fabricated through sintering. Nine chrysotile wicks are sintered with different compositions of binders (bentonite and dextrin) and pore‐forming agent NaCl at sintering temperatures of 500°C, 600°C, and 700°C with a sintering time of 30 min. The wick properties, for instance, porosity, permeability, wettability, and capillary rise are studied owing to sintering temperature. Consequently, it is observed that a pure chrysotile powdered wick at a sintering temperature of 600°C exhibits a high porosity of 61.8% with permeability 1.04 × 10−13 m2 and a capillary rise of 4.5 cm in 30 s and is considered optimal. This optimal wick is used for performance evaluation in compact loop heat pipe and a decrease of 36.1% in thermal resistance is found when compared with copper mesh wick in a loop heat pipe. The lowermost thermal resistance originates to be 0.147 K/W at 120 W with wall temperature 57.7°C. This indicates that loop heat pipe with sintered chrysotile wick can operate at lower heat loads efficiently when compared with copper mesh wick and as heat load increases a chance of dry out condition occurs. The highest evaporative heat transfer coefficient obtained is 65.7 kW/m2 K at a minimum heat load.
A 24GHz CMOS UWB Radar IC with IQ Correlation Receiver for Short Range Human Detection

A fully integrated 24 GHz UWB radar IC is presented. The IQ correlation receiver is employed for the detection fidelity and range extension. The transmitter is a VCO based impulse generator. The carrier frequency and bandwidth of the UWB signal can be tunable in the range of 21.8 - 24.5 GHz and 0.18 - 3 GHz, respectively. The equivalent sample resolution is 195 ps. The radar module using IC provides the maximum detection range for moving human up to 12.5 m within 120.27 mW power consumption.
Mechanisms for the Anomalous Properties of Eu-Chalcogenides Alloys. I.

Various anomalous magneto-optic and magnetic properties of Eu 1- x Gd x Se are explained on the magnetic exciton and the magnetic impurity state model. It is shown that the optically active magnetic exciton with the lowest energy is of the type of (5 d –5 d ), that is, 5 d character on the central Eu 3+ and also 5 d on the nearest neighbour Eu 2+ . The origin of the anomalous magneto-optic properties is attributed to the d – f exchange interaction on the nearest neighbour Eu 2+ ions. While, for the magnetic impurity state, (6 s –6 s ) type state has the lowest energy. At low temperature, a giant spin molecule ( S =46) composed of the spin of an impurity electron and the 4 f spin on the central Gd 3+ ion and the n.n. Eu 2+ ion is constructed through the s – f exchage interaction among them. However, this giant spin molecule disappears rather quickly as temperature increases exceeding J 1/κ , where J 1 is the s – f exchange constant at n.n. Eu 2+ and is estimated as 25κ. The anomalous magnetic properties of .
Wireless Network Fault Localization via Metric Classification

The wireless ecosystem tends to be saturated and complicated due to a great number of network devices and applications deployed. Fault localization is critically important for the reliability of the wireless network system. However, it is difficult to localize reoccurring wireless network faults due to the inconsistent quality of monitoring metrics as well as the overlap of multiple fault root causes. This paper proposes FTCFL, a new wireless network fault localization framework based on feature engineering, the neural-network-based feature extractor and the time series classifier. FTCFL enhances raw metrics with incon-sistent quality based on feature engineering including the pseudo standardization, the Kalman filter and the feature selection. Then FTCFL applies the neural-network-based feature extractor and the time series classifier to localize reoccurring wireless network faults based on enhanced metrics. The experimental evaluation is performed in a real-world telecommunication dataset collected from live 5G wireless networks. The experimental results show that FTCFL is able to localize multiple fault root causes in the wireless network system with the MicroF1 of 0.876.
Temporal localized structures in a photonic crystal fiber resonator

We investigate analytically and numerically the eﬀect of the higher order dispersion on the dynamic of a photonic crystal fiber resonator pumped continuously by a coherent injected beam. The linear stability analysis shows that the fourth order dispersion bounds the zone of modulation instability between two pump power levels and predict a motion of solution induced by the broken symmetry mediated by the third order dispersion. We perform a weakly non linear analysis on the vicinity of the first threshold associated with modulation instability. The amplitude and the non linear correction of velocity of periodic structures are estimated. This analysis allowed us to determine the threshold of apparition of bright localized structures and we have also shown that dark localized structures can be stabilized on the neighborhood of the second threshold of modulation instability. Numerical solutions of the governing equations are in close agreement with analytical predictions.
Pyrotinib combining with radiotherapy on breast cancer with brain metastasis

With the extensive application of anti-human epidermal growth factor receptor-2 (HER2) targeted therapy, the prognosis of HER2-positive breast cancer brain metastasis (BCBM) has been improved greatly. Due to the lack of prospective randomized controlled studies; however, the treatment of active brain metastasis (BM) remains a difficulty in clinic. Based upon the retrospective studies, an effective approach of radiotherapy combined with pyrotinib in HER2-positive BCBM treatment was investigated in present research. In all, 29 patients who had active BM in HER2-positive breast cancer (BC) and underwent whole-brain radiotherapy (WBRT) combined with pyrotinib from January 2019 to May 2021 were enrolled. The progression-free survival (PFS), overall survival (OS), clinical benefit rate (CBR), objective response rate (ORR), and drug-related adverse events (AEs) were analyzed among patients undergoing WBRT combined with concurrent or sequence pyrotinib + capecitabine. After the systematic treatments using WBRT combined with pyrotinib + capecitabine, the mPFS and mOS of BM patients were 6.5 months and 15.5 months, respectively. PFS (7.2 vs 6.2 months, p = 0.038) and OS (19.0 vs 14.0 months, p = 0.014) were longer after sequence treatments than those after concurrent treatment. The central nervous system (CNS) ORR of sequence treatment was superior to that of concurrent treatment (80.4% vs 58.6%, p < 0.05). Vomiting (17.2%) and diarrhea (10.3%) were the most common adverse reactions ⩾ grade 3. WBRT combined with pyrotinib is safe and effective for the treatments of active BM in HER2-positive BC. WBRT combined with sequence pyrotinib + capecitabine is more effective and less toxic than concurrent treatment. Therefore, sequence treatment is potentially a preferred regimen for patients with active BM in HER2-positive BC. The size and number of BM lesions, presence or absence of hepatic metastasis, and combination mode of radiotherapy and targeted therapy are independent risk factors for active BM prognosis.
Spectroscopic characteristics of polar plumes

Extreme ultraviolet observations of plumes in polar coronal holes are presented and their spectroscopic signatures discussed. The study focuses on the base of plumes seen on the disk of the Sun with the Coronal Diagnostic Spectrometer (CDS) on the Solar and Heliospheric Observatory (SOHO) satellite. Spectroscopic diagnostic techniques are applied to characterise the plumes in terms of density, temperature, emission measure and element abundance. Attention is drawn to the particular limitations of some of the techniques when applied to plume structures. In particular, we revisit the Widing & Feldman (1992) findings of a plume having a large first ionization potential (FIP) effect of 10, showing that instead the Skylab data are consistent with no FIP effect. We present for the first time CDS-GIS (grazing incidence spectrometer) observations of a plume. These observations have been used to confirm the results obtained from normal incidence (NIS) observations. We find that polar plumes exhibit the same characteristics as the Elephant's Trunk equatorial plume. The most striking characteristic of the plume bases is that they are near-isothermal with a peak emission measure at transition region temperatures $\simeq 8 \times 10^5$ K. At these temperatures, plumes have averaged densities $N{\rm _{e}} \simeq 1.2 \times 10^{9}$ cm -3 , about twice the value of the surrounding coronal hole region. Element abundances in the plumes are found to be close to photospheric, with the exception of neon which appears to be depleted by 0.2 dex relative to oxygen. The absence of a significant FIP effect in plumes is consistent with fast solar wind plasma, although it is not sufficient to prove a link between the two. Finally, we present a comparison between GIS spectra and the SOHO EIT (EUV Imaging Telescope) broad-band images, showing that temperatures derived from the EIT ratio technique are largely overestimated, for plumes and coronal holes. This is partly due to the fact that the so called “Fe XII 195 A” and “Fe XV 284 A” filters are not isothermal, and in coronal holes and plumes lower-temperature lines dominate the EIT signal.
Weighted and reweighted approximate message passing

In this paper we derive weighted and reweighted AMP algorithms for signal reconstruction from compressed sensing measurements. Weighted AMP incorporates prior support information into the AMP algorithm and iteratively solves the weighted I1 minimization which is much faster than the usual linear programming algorithms used to solve this problem. We also introduce a reweighting scheme for regular and weighted AMP algorithms which enhances the recovery performance of both regular and weighted AMP while still maintaining the low complexity nature of AMP algorithms.
Basic structures of hyperbolic relaxation systems

This work is concerned with basic structural properties of first-order hyperbolic systems with source terms divided by a small parameter ε. We identify a relaxation criterion necessary for the solution sequences indexed with ε to have reasonable limits as ε goes to zero. This relaxation criterion is shown to imply hyperbolicity of the reduced systems governing the limits. Moreover, we introduce a so-called GC-stability theory and strengthen the hyperbolicity result. The latter shows that there are no linearly stable hyperbolic relaxation approximations for non-hyperbolic conservation laws.
Measuring the nonlinearity of silicon piezoresistance by tensile loading of a submicron diameter fiber using a microinstrument

This report presents a mechanical loading experiment utilizing a microelectromechanical system microinstrument in which we stretched a 150 nm diameter n-type silicon fiber above 1% strain at room temperature and measured the longitudinal piezoresistive effect. The piezoresistive effect at these strains has not been measured. Piezoresistive coefficients up to the third order are required to fit the 0% to 1% strain measurement data with high statistical confidence. Our first-order coefficient matches results that are published in literature. However, compared with published second-order piezoresistive coefficients, the highest-order coefficient available, our result differs in magnitude and sign. Our analysis suggests that previously published second-order piezoresistive coefficients are not reliable due to limited data measured at small strain values (<0.1%), where the second-order piezoresistive effect is small.
Stevia and Stevioside Attenuate Liver Steatosis through PPARα-Mediated Lipophagy in db/db Mice Hepatocytes

Lipophagy, a type of autophagy that breaks down lipid droplets, is essential in the regulation of intracellular lipid accumulation and intracellular free fatty acid levels in numerous organisms and metabolic conditions. We investigated the effects of Stevia rebaudiana Bertoni (S), a low-calorie sweetener, and stevioside (SS) on hepatic steatosis and autophagy in hepatocytes, as well as in db/db mice. S and SS reduced the body and liver weight and levels of serum triglyceride, total cholesterol, and hepatic lipogenic proteins. In addition, S and SS increased the levels of fatty acid oxidase, peroxisome proliferator-activated receptor alpha (PPARα), and microtubule-associated protein light chain 3 B but decreased that of sequestosome 1 (p62) in the liver of db/db mice. Additionally, Beclin 1, lysosomal associated membrane protein 1, and phosphorylated adenosine monophosphate-activated protein kinase protein expression was augmented following S and SS treatment of db/db mice. Furthermore, the knockdown of PPARα blocked lipophagy in response to SS treatment in HepG2 cells. These outcomes indicate that PPARα-dependent lipophagy is involved in hepatic steatosis in the db/db mouse model and that SS, a PPARα agonist, represents a new therapeutic option for managing associated diseases.
Multiyear lunar observations from TRMM/VIRS, Terra/MODIS, and Aqua/MODIS

This work demonstrates how lunar data are used by three different imaging radiometers: the Visible and InfraRed Scanner (VIRS) onboard the Tropical Rainfall Measuring Mission (TRMM) and the MODerate resolution Imaging Spectroradiometers (MODIS) onboard the EOS Terra and Aqua satellites. Using the measured lunar data, radiometric models have been developed for the on-orbit calibration of the remote sensing systems' reflected solar bands. For the VIRS with spectral bands nearly identical to several of the MODIS bands, the integrated lunar reflectance data were measured, from Jan 1998 to Jun 2006, at phase angles ranging from 1.2° to 120.2°. For the two nearly identical MODIS instruments, the lunar irradiance was measured at phase angles from 54° to 56°. We present stability trending of the lunar data at selected phase angles over periods of four to eight years and use these observations to examine instrument radiometric stability. Moreover, we discuss implications of these results.
The Association of PLAUR Genotype and Soluble suPAR Serum Level with COVID-19-Related Lung Damage Severity

Uncovering the risk factors for acute respiratory disease coronavirus 2019 (COVID-19) severity may help to provide a valuable tool for early patient stratification and proper treatment implementation, improving the patient outcome and lowering the burden on the healthcare system. Here we report the results of a single-center retrospective cohort study on 151 severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-infected symptomatic hospitalized adult patients. We assessed the association of several blood test measurements, soluble urokinase receptor (uPAR) serum level and specific single nucleotide polymorphisms of ACE (I/D), NOS3 (rs2070744, rs1799983), SERPINE1 (rs1799768), PLAU (rs2227564) and PLAUR (rs344781, rs2302524) genes, with the disease severity classified by the percentage of lung involvement on computerized tomography scans. Our findings reveal that the T/C genotype of PLAUR rs2302524 was independently associated with a less severe lung damage (odds ratio 0.258 [0.071–0.811]). Along with high C-reactive protein, fibrinogen and soluble uPAR serum levels turned out to be independently associated with more severe lung damage in COVID-19 patients. The identified factors may be further employed as predictors of a possibly severe COVID-19 clinical course.
Soundscape characterization in selected areas of Central London

The Mayor of London's Ambient Noise Strategy 'Sounder City' is the first UK public policy document to promote, not just noise reduction, but positive soundscape management. For its prescriptions to be put into full effect, psychoacoustic methods are needed to characterize existing areas where action may be needed to counteract existing noise pollution. To this aim, the soundscape characterization of two different areas in Central London will be presented in this work, where the two selected parks have in common the presence of a heavily trafficked road nearby. The acoustical experience of passers‐by will be mapped using an indicator related to the time history of sound energy, related in previous studies to people's perceptions. Comparison with the same description performed by classical psychoacoustic parameters and perspectives for innovative, positive soundscape based actions will be discussed.
Diamond crystals as cosserat continua with constrained rotation

The elastic constants of diamond and its local moment of inertia are estimated. The diamond crystal is assumed as a Cosserat continuum with constrained rotation. After a brief survey on the dispersion relations for waves in the continuum, the micropolar material constants are evaluated from the experimental data on the lattice vibrations in diamond. Numerical results are presented. Les auteurs calculent les constantes elastiques, et le coefficient d'inertie locale, pour cristaux de diamant. Le cristal de diamant est regarde comme un milieu de Cosserat dans lequel la microrotation est egale a la rotation macroscopique de deplacements. D'apres une etude des dispersions d'ondes dans cet milieu de Cosserat, les coefficients materiels pour la theorie micropolaire sont determines a partir d'experiences de vibrations de resau de diamant. On obtient des valeurs numeriques.
X-ray nebular models

Theoretical models are presented for the temperature and ionization structure of spherically symmetric, constant density, gaseous nebulae surrounding compact X-ray sources and for the optical, UV, and X-ray spectra emerging from the nebulae. The structure is determined by assuming a local balance between heating and cooling in the gas, and the radiation field is found by solving a simplified equation of transfer. The calculations include an accurate and comprehensive treatment of the atomic processes affecting the state of the gas and the radiation field. The destruction of line radiation during resonance scattering causes models to be significantly hotter and more highly ionized than previous models of the same type. Model results are presented for a wide variety of gas densities and X-ray source spectra, scaling laws which allow these results to be generalized to a wide variety of astrophysical solutions are discussed, and column densities of multiply charged species are tabulated.