Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing how Spirituality Affects Resiliency in the Pediatric Healthcare Practitioner

A literature review was conducted to examine the role of spirituality with resiliency in the pediatric workplace. Two themes emerged from the literature review: healthcare practitioners desire to have a sense of belonging at work and the utilization of chaplains is helpful. This study aims to discover how practitioners experience spiritual health in the workplace and identify interventions that enhance resiliency with the challenges of pediatrics. Implications from this study are applied to chaplaincy and research.
In Vitro and In Vivo Antimicrobial Activity of Hypochlorous Acid against Drug-Resistant and Biofilm-Producing Strains

Currently, drug-resistant infections are increasing and there are fewer antibiotics available to treat them. Therefore, there is an urgent need to find new antibiotics and nonantimicrobial strategies to treat these infections. We present a new nonantibiotic strategy based on hypochlorous acid generation to treat long-term catheter-related and chronic wounds infections. ABSTRACT The aims of this study were as follows. First, we determined the antimicrobial efficacy of hypochlorous acid (HClO) against bacterial, fungal, and yeast strains growing planktonically and growing in biofilms. Second, we sought to compare the activity of the combination of daptomycin and HClO versus those of the antimicrobial agents alone for the treatment of experimental catheter-related Staphylococcus epidermidis infection (CRI) using the antibiotic lock technique (ALT) in a rabbit model. HClO was generated through direct electric current (DC) shots at determined amperages and times. For planktonic susceptibility studies, 1 to 3 DC shots of 2, 5, and 10 mA from 0 to 300 s were applied. A DC shot of 20 mA from 0 to 20 min was applied to biofilm-producing strains. Central venous catheters were inserted into New Zealand White rabbits, inoculated with an S. epidermidis strain, and treated with saline solution or ALT using daptomycin (50 mg/mL), HClO (20 mA for 45 min), or daptomycin plus HClO. One hundred percent of the planktonic bacterial, fungal, and yeast strains were killed by applying one DC shot of 2, 5, and 10 mA, respectively. One DC shot of 20 mA for 20 min was sufficient to eradicate 100% of the tested biofilm-producing strains. Daptomycin plus HClO lock therapy showed the highest activity for experimental CRI with S. epidermidis. HClO could be an effective strategy for treating infections caused by extensively drug-resistant or multidrug-resistant and biofilm-producing strains in medical devices and chronic wounds. The results of the ALT using daptomycin plus HClO may be promising. IMPORTANCE Currently, drug-resistant infections are increasing and there are fewer antibiotics available to treat them. Therefore, there is an urgent need to find new antibiotics and nonantimicrobial strategies to treat these infections. We present a new nonantibiotic strategy based on hypochlorous acid generation to treat long-term catheter-related and chronic wounds infections.
Freeze dehydration vs. supercooling of mesophyll cells: Impact of cell wall, cellular and tissue traits on the extent of water displacement

Abstract The extent of freeze dehydration of mesophyll cells in response to extracellular ice varies from supercooling to severe freezing cytorrhysis. The structural factors involved are poorly understood. In a comparison of mesophyll cells of 11 species, the factors “cell wall”, “cellular” and “tissue” traits were investigated. The extent of freeze dehydration was quantified as reduction in the sectional area during controlled freezing in the presence of ice. The cell wall thickness, cell size, cell area and the relative area of intercellular spaces were determined. The modulus of elasticity was determined by psychrometry. To grasp the relationships between factors and with freeze dehydration, we applied a principal component analysis. The first two components explain 84% of the variance in the dataset. The first principal component correlated negatively with the extent of freeze dehydration and relative area of intercellular spaces, and positively with the squared cell wall thickness to cell size ratio, elasticity and cell wall thickness. The cell size parameters determined the second principal component. Supercooling appeared preferable in cells with a high squared cell wall thickness to cell size ratio and a low relative area of intercellular spaces. Such factors are hypothesised to affect the magnitude of negative turgor pressure being built up below the turgor loss point. Negative turgor pressure slows dehydration by reducing the water potential gradient to the extracellular ice. With high levels of freeze dehydration, sufficient intercellular spaces for extracellular ice accommodation are needed. The low relative area of intercellular spaces increases cell‐to‐cell contact area and could support tissue stability.
Gravitational wave astronomy with the SKA

On a time scale of years to decades, gravitational wave (GW) astronomy will become a reality. Low frequency (∼10 −9 Hz) GWs are detectable through long-term timing observations of the most stable pulsars. Radio observatories worldwide are currently carrying out observing programmes to detect GWs, with data sets being shared through the International Pulsar Timing Array project. One of the most likely sources of low frequency GWs are supermassive black hole binaries (SMBHBs), detectable as a background due to a large number of binaries, or as continuous or burst emission from individual sources. No GW signal has yet been detected, but stringent constraints are already being placed on galaxy evolution models. The SKA will bring this research to fruition. In this chapter, we describe how timing observations using SKA1 will contribute to detecting GWs, or can confirm a detection if a first signal already has bee n identified when SKA1 commences observations. We describe how SKA observations will identify the source(s) of a GW signal, search for anisotropies in the background, improve models of galaxy evolution, test theories of gravity, and characterise the early inspiral phase o f a SMBHB system. We describe the impact of the large number of millisecond pulsars to be discovered by the SKA; and the observing cadence, observation durations, and instrumentation required to reach the necessary sensitivity. We describe the noise processes that wi ll influence the achievable precision with the SKA. We assume a long-term timing programme using the SKA1-MID array and consider the implications of modifications to the current desig n. We describe the possible benefits from observations using SKA1-LOW. Finally, we describe GW detection prospects with SKA1 and SKA2, and end with a description of the expectations of GW astronomy.
Search engine optimization for scientific publications: How one can find your needle in the haystack

Since the introduction of the Internet there has been a massive improvement of connections between scientists, patients, stakeholders and other persons interested in scientific publications. With the development of web 2.0, global connections and the rise of social media platforms such as Twitter, Instagram, Facebook and others, there has been a tremendous amount of data published with unimaginable large numbers of exabytes. With this, search engines such as Google have been playing a very important role in finding the relevant information you need on the Internet. Next to the production of general data, there has also been a major increase in the production and publications of scientific data, which has been estimated to cover approximately 50 million scientific papers up till 2009 since the year 1665, and additionally, this pool of scientific papers is currently growing with >7.5 million each year. Moreover, there is a growing number of publications each year with an accompanying growth in the number of scientific journals. Still, when adjusted for a stable number of scientific journals, the number of publication per journal per year keeps rising. It is no surprise that this gigantic and incomprehensible number of scientific papers need to be tracked down and found in the right way. At this point, approximately 53% of the traffic to scientific websites such as Wiley, come from search engines. One does not need to be a scientist to understand that only if you can (easily) get found, you can get read, shared and eventually cited. To be able to get found, you need to tag and optimize your paper the right way so search engines such as Google can correctly index the paper and lead interested persons to the right papers. As an author, or as a journal, you want people to find your article better than anyone elses. This is what Search engine optimisation (SEO) is about.
A pan-cancer analysis of matrisome proteins reveals CTHRC1 and a related network as major ECM regulators across cancers

The extracellular matrix in the tumour microenvironment can regulate cancer cell growth and progression. A pan-cancer analysis of TCGA data from 30 cancer types, identified the top 5% of matrisome genes with amplifications or deletions in their copy number, that affect their expression and cancer survival. A similar analysis of matrisome genes in individual cancers identified CTHRC1 to be significantly altered. CTHRC1, a regulator of collagen synthesis, was identified as the most prominently upregulated matrisome gene of interest across cancers. Differential gene expression analysis identified 19 genes whose expression is increased with CTHRC1. STRING analysis of these genes classified them as ‘extracellular’, involved most prominently in ECM organization and cell adhesion. KEGG analysis showed their involvement in ECM-receptor and growth factor signalling. Cytohubba analysis of these genes revealed 13 hub genes, of which MMP13, POSTN, SFRP4, ADAMTS16 and FNDC1 were significantly altered in their expression with CTHRC1 and seen to affect survival across cancers. This could in part be mediated by their overlapping roles in regulating ECM (collagen or fibronectin) expression and organisation. In breast cancer tumour samples CTHRC1 protein levels are significantly upregulated with POSTN and MMP13, further supporting the need to evaluate their crosstalk in cancers.
Endoperoxides Compounds for Highly Efficient Cancer Treatment under Hypoxia.

Photodynamic therapy (PDT) for cancer treatment has garnered great attention, with promising non-invasiveness, low side effects, and spatiotemporal selectivity. However, the hypoxic microenvironment in solid tumours remains a serious resistant factor to limit PDT effects. Endoperoxides are always utilized as chemical storage or supplier of singlet oxygen ( 1 O 2 ), the active substance for PDT in materials and other domains. Recent reports indicated that this type of compounds could remarkably enhance the therapeutic effects of PDT under hypoxia. This concept mainly introduces a few representative endoperoxides and outlook of their potent application for the treatment of hypoxic cancer cells.
Shared Decision-Making as a Tool for Navigating Multi-Stakeholder Discrepancies in Youth Psychotherapy

ABSTRACT Objective Discrepancies among the key stakeholders in youth psychotherapy (e.g., caregivers, youths) commonly present an obstacle to treatment planning, forcing clinicians to align with one perspective over another and increasing the likelihood of a treatment plan that is not fully responsive to divergent opinions. At the same time, multi-stakeholder discrepancies can also offer opportunities to build an inclusive, effective treatment plan, guided by the integration of numerous sources of domain-specific knowledge related to the concerns for which families seek clinical care. Method We aim to: 1) investigate the degree to which multi-stakeholder discrepancies are observed when youths and caregivers are invited to report their treatment priorities, rather than the presence and severity of youth symptoms, 2) describe the rationale for, as well as the promise and challenges of, shared decision-making (SDM)—an approach designed to facilitate multi-stakeholder collaboration during treatment planning, 3) provide a case example illustrating how a clinician, youth, and caregiver could use SDM to navigate discrepancies and identify therapy targets, and 4) propose future directions for exploring the potential value of SDM in youth psychotherapy. Results Different levels of multi-stakeholder agreement were observed when caregivers and youths were asked to identify their treatment priorities, compared to youth symptom presence and severity, revealing nuances in multi-stakeholder agreement in youth psychotherapy. Conclusions Multi-stakeholder discrepancies can inform treatment planning processes, and SDM may be an effective approach for navigating them and building a treatment plan that integrates the perspective of all stakeholders in youth psychotherapy.
Brain structure correlates with auditory function in children diagnosed with auditory neuropathy spectrum disorder

Auditory neuropathy spectrum disorder (ANSD) is a term for a collection of test results which indicate disruption of the auditory signal at some point along the neural pathway. This results in a spectrum of functional outcomes, ranging from reasonably normal hearing to profound hearing loss. This study assessed brain structure changes and behavioral correlates in children diagnosed with ANSD.
Efficacy and safety of 3‐n‐butylphthalide combined with endovascular treatment in acute ischemic stroke due to large vessel occlusion

The drug 3‐n‐butylphthalide (NBP) was developed and approved in China, where it has been used to treat ischemic cerebrovascular diseases. It is also considered to have a neuroprotective effect. This study aimed to evaluate whether NBP combined with endovascular treatment (EVT) can improve the clinical outcome and safety in patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO).
Numerical Solution of Hyperbolic Partial Differential Equations

Preface 1. Introduction to partial differential equations 2. Scalar hyperbolic conservations laws 3. Nonlinear scalar laws 4, Nonlinear hyperbolic systems 5. Methods for scalar laws 6. Methods for hyperbolic systems 7. Methods in multiple dimensions 8. Adaptive mesh refinement Bibliography Index.
Pathogenic variants in GCSH encoding the moonlighting H-protein cause combined nonketotic hyperglycinemia and lipoate deficiency

Abstract Maintaining protein lipoylation is vital for cell metabolism. The H-protein encoded by GCSH has a dual role in protein lipoylation required for bioenergetic enzymes including pyruvate dehydrogenase and 2-ketoglutarate dehydrogenase, and in the one-carbon metabolism through its involvement in glycine cleavage enzyme system, intersecting two vital roles for cell survival. Here, we report six patients with biallelic pathogenic variants in GCSH and a broad clinical spectrum ranging from neonatal fatal glycine encephalopathy to an attenuated phenotype of developmental delay, behavioral problems, limited epilepsy and variable movement problems. The mutational spectrum includes one insertion c.293-2_293–1insT, one deletion c. 122_(228 + 1_229–1) del, one duplication of exons 4 and 5, one nonsense variant p.Gln76*and four missense p.His57Arg, p.Pro115Leu and p.Thr148Pro and the previously described p.Met1? Via functional studies in patient’s fibroblasts, molecular modeling, expression analysis in GCSH knockdown COS7 cells and yeast, and in vitro protein studies, we demonstrate for the first time that most variants identified in our cohort produced a hypomorphic effect on both mitochondrial activities, protein lipoylation and glycine metabolism, causing combined deficiency, whereas some missense variants affect primarily one function only. The clinical features of the patients reflect the impact of the GCSH changes on any of the two functions analyzed. Our analysis illustrates the complex interplay of functional and clinical impact when pathogenic variants affect a multifunctional protein involved in two metabolic pathways and emphasizes the value of the functional assays to select the treatment and investigate new personalized options.
Conductance quantization in strongly disordered graphene ribbons

We present numerical studies of conduction in graphene nanoribbons with different types of disorder. We find that even when defect scattering depresses the conductance to values two orders of magnitude lower than $2{e}^{2}/h$, equally spaced conductance plateaus occur at moderately low temperatures due to enhanced electron backscattering near subband edge energies if bulk vacancies are present in the ribbon. This work accounts quantitatively for the surprising conductance quantization observed by Lin et al. [Phys. Rev. B 78, 161409(R) (2008)] in ribbons with such low conductances.
The Viral Load of Epstein-Barr Virus in Blood of Children after Hematopoietic Stem Cell Transplantation.

Objective To detect the Epstein-Barr virus (EBV) viral load of children after hematopoietic stem cell transplantation (HSCT) using chip digital PCR (cdPCR). Methods The sensitivity of cdPCR was determined using EBV plasmids and the EBV B95-8 strain. The specificity of EBV cdPCR was evaluated using the EBV B95-8 strain and other herpesviruses (herpes simplex virus 1, herpes simplex virus 2, varicella zoster virus, human cytomegalovirus, human herpesvirus 6, and human herpesvirus 7). From May 2019 to September 2020, 64 serum samples of children following HSCT were collected. EBV infection and the viral load of serum samples were detected by cdPCR. The epidemiological characteristics of EBV infections were analyzed in HSCT patients. Results The limit of detection of EBV cdPCR was 110 copies/mL, and the limit of detection of EBV quantitative PCR was 327 copies/mL for the pUC57-BALF5 plasmid. The result of EBV cdPCR was up to 121 copies/mL in the EBV B95-8 strain, and both were more sensitive than that of quantitative PCR. Using cdPCR, the incidence of EBV infection was 18.75% in 64 children after HSCT. The minimum EBV viral load was 140 copies/mL, and the maximum viral load was 3,209 copies/mL using cdPCR. The average hospital stay of children with EBV infection (184 ± 91 days) was longer than that of children without EBV infection (125 ± 79 days), P = 0.026. Conclusion EBV cdPCR had good sensitivity and specificity. The incidence of EBV infection was 18.75% in 64 children after HSCT from May 2019 to September 2020. EBV cdPCR could therefore be a novel method to detect EBV viral load in children after HSCT.
Radio frequency signal detection by ballistic transport in Y-shaped graphene nanoribbons

We report on the fabrication and room temperature measurements of a high frequency electrical signal detector. The device is based on the ballistic transport in graphene to detect a high frequency signal. The observed response is linear in the considered power range (-40dBm - 0dBm) and exhibits a sensitivity as high as 10 Volts/Watt. Finally the device detected signals up to 50GHz with a maximum response at 10GHz. This device outperforms any previously reported carbon based detectors in frequency response and compares to current state of the art Schottky based detectors in dynamic range.
It's Time to Replace TCP in the Datacenter

In spite of its long and successful history, TCP is a poor transport protocol for modern datacenters. Every significant element of TCP, from its stream orientation to its expectation of in-order packet delivery, is wrong for the datacenter. It is time to recognize that TCP's problems are too fundamental and interrelated to be fixed; the only way to harness the full performance potential of modern networks is to introduce a new transport protocol into the datacenter. Homa demonstrates that it is possible to create a transport protocol that avoids all of TCP's problems. Although Homa is not API-compatible with TCP, it should be possible to bring it into widespread usage by integrating it with RPC frameworks.
Higher-order rogue wave fission under the effects of third-order dispersion, self-steepening and self-frequency shift

Using the generalised nonlinear Schr\"odinger equation, we investigate how the effect of third-order dispersion, self-steepening, and Raman-induced-self-frequency shift have an impact on the higher-order rogue waves. We observe that individually each effect breaks apart the higher-order rogue waves reducing to their constituent fundamental parts similar to how a higher-order soliton undergoes fission. We demonstrate that under the influence of their combined effect, the disintegrated elements of higher-order rogue waves become fundamental solitons creating asymmetrical spectral profiles that generate both red and blue-shifted frequency components. These observations reveal the mechanisms that create a large number of solitons in the process of modulation instability-induced supercontinuum generation from a continuous-wave background in optical fibers.
Robust Scheduling with Improved Uncertainty Sets via Purchase of Distributed Predictive Information

—Robust scheduling is an essential way to cope with uncertainty. However, the rising unpredictability in net demand of distributed prosumers and the lack of relevant data make it difﬁcult for the operator to forecast the uncertainty well. This leads to inaccurate, or even infeasible, robust scheduling strategies. In this paper, a novel two-stage robust scheduling model is developed, which enables the operator to purchase predictive information from distributed prosumers to enhance scheduling efﬁciency. An improved uncertainty set with a smaller variation range is developed by combining the forecasts from the operator and prosumers. Since the improved uncertainty set is inﬂuenced by the ﬁrst-stage information purchase related decisions, the proposed model eventually becomes a case of robust optimization with decision-dependent uncertainty (DDU). An adaptive column-and-constraint generation (C&CG) algorithm is developed to solve the problem within a ﬁnite number of iterations. The potential failures of traditional algorithms in detecting feasibility, guaranteeing convergence, and reaching optimal strategies under DDU are successfully circumvented by the proposed algorithm. Case studies demonstrate the effectiveness, necessity, and scalability of the proposed method.
High Probability Convergence for Accelerated Stochastic Mirror Descent

In this work, we describe a generic approach to show convergence with high probability for stochastic convex optimization. In previous works, either the convergence is only in expectation or the bound depends on the diameter of the domain. Instead, we show high probability convergence with bounds depending on the initial distance to the optimal solution as opposed to the domain diameter. The algorithms use step sizes analogous to the standard settings and are universal to Lipschitz functions, smooth functions, and their linear combinations.
Learnable Acoustic Frontends in Bird Activity Detection

Autonomous recording units and passive acoustic monitoring present minimally intrusive methods of collecting bioacoustics data. Combining this data with species agnostic bird activity detection systems enables the monitoring of activity levels of bird populations. Unfortunately, variability in ambient noise levels and subject distance contribute to difficulties in accurately detecting bird activity in recordings. The choice of acoustic frontend directly affects the impact these issues have on system performance. In this paper, we benchmark traditional fixed-parameter acoustic frontends against the new generation of learnable frontends on a wide-ranging bird audio detection task using data from the DCASE2018 BAD Challenge. We observe that Per-Channel Energy Normalization is the best overall performer, achieving an accuracy of 89.9%, and that in general learnable frontends significantly outperform traditional methods. We also identify challenges in learning filterbanks for bird audio in a constrained space.