Predicting blood pressure in aortas treated for coarctation

Coarctation of the aorta is a narrowing of the aorta that is present at birth. Treatments for coarctation of the aorta affect the aorta wall stiffness. This study uses a 1D model to predict the effects of altered wall stiffness. Stent treatments increase both blood pressure and the radial change of the aorta wall over a heartbeat cycle, compared to both healthy aortas and the resection and end-to-end anastomosis treatment. References A. M. Rudolph, M. A. Heymann, and U. Spitznas. Hemodynamic considerations in the development of narrowing of the aorta. Am. J. Cardiol. 30(5):514–525, 1972. doi:10.1016/0002-9149(72)90042-2 N. S. Talner and M. A. Berman. Postnatal development of obstruction in coarctation of the aorta: role of the ductus arteriosus. Pediatrics , 56(4):562–569, 1975. http://pediatrics.aappublications. org/content/56/4/562 P. S. Rao. Coarctation of the aorta. Curr. Cardiol. Rep. , 7(6):425–434, 2005. doi:10.1007/s11886-005-0060-0 Z. Keshavarz-Motamed, E. R. Edelman, P. K. Motamed, J. Garcia, N. Dahdah, and L. Kadem. The role of aortic compliance in determination of coarctation severity: Lumped parameter modeling, in vitro study and clinical evaluation. J. Biomech. 48(16):4229–4237, 2015. doi:10.1016/j.jbiomech. 2015.10. 017 M. Campbell. Natural history of coarctation of the aorta. Br. Heart J. 32(5):633–640, 1970. doi:10.1136/hrt.32. 5.633 L. M. S. Padua, L. C. Garcia, C. J. Rubira, and P. E. de Oliveira Carvalho. Stent placement versus surgery for coarctation of the thoracic aorta. Cochrane Db. Syst. Rev. 5:CD008204, 2012. doi:10.1002/14651858.CD008204. pub2 R. Jurcut, A. M. Daraban, A. Lorber, D. Deleanu, M. S. Amzulescu, C. Zara, B. A. Popescu, and C. Ginghina. Coarctation of the aorta in adults: what is the best treatment? Case report and literature review. J. Med. Life , 4(2):189–195, 2011. http://www.ncbi. nlm.nih. gov/pmc/articles/PMC3124275/ J. Alastruey, T. Passerini, L. Formaggia, and J. Peiro. Physical determining factors of the arterial pulse waveform: theoretical analysis and calculation using the 1-D formulation. J. Eng. Math. 77(1):19–37, 2012. doi:10.1007/s10665-012-9555-z J. Alastruey, M. Willemet, K. Lau, S. Epstein, and S. Vennin. Nektar1D, Haemodynamic Modelling Research Group, Kings College London, 2016. http://haemod.uk/nektar J. Alastruey, K. H. Parker, and S. J. Sherwin. Arterial pulse wave haemodynamics. 11th International Conference on Pressure Surges , pg. 401–442, 2012. http://wwwf.imperial. ac.uk/ssherw/spectralhp/papers/PulseSurges_2012. pdf N. P. Smith, A. J. Pullan, and P. J. Hunter. An anatomically based model of transient coronary blood flow in the heart. SIAM J. Appl. Math. 62(3):990–1018, 2002. doi:10.1137/S0036139999355199 N. Westerhof, F. Bosman, C. J. De Vries, and A. Noordergraaf. Analog studies of the human systemic arterial tree. J. Biomech. 2(2):121–134, 1969. doi:10.1016/0021-9290(69)90024-4 N. Xiao, J. Alastruey, and C. A. Figueroa. A systematic comparison between 1-D and 3-D hemodynamics in compliant arterial models. Int. J. Numer. Meth. Biomed. Eng. 30(2):204–231, 2014. doi:10.1002/cnm.2598 C. A. Figueroa, I. E. Vignon-Clementel, K. E. Jansen, T. J. R. Hughes, and C. A. Taylor. A coupled momentum method for modeling blood flow in three-dimensional deformable arteries. Comput. Meth. Appl. Mech. Eng. 195(41\T1\textendash 43):5685–5706, 2006. doi:10.1016/j.cma. 2005.11. 011 E. Boileau, P. Nithiarasu, P. J. Blanco, L. O. Muller, F. E. Fossan, L. R. Hellevik, W. P. Donders, W. Huberts, M. Willemet, and J. Alastruey. A benchmark study of numerical schemes for one-dimensional arterial blood flow modelling. Int. J. Numer. Meth. Biomed. Eng. 31(10):e02732, 2015. doi:10.1002/cnm.2732