Miracle-dz/UniFAR-FTUs huggingface dataset:
Transient Stability Analysis of Islanded AC Microgrids with a Significant Share of Virtual Synchronous Generators

As an advanced control method that could bring extra inertia and damping characteristics to inverter-based distributed generators, the virtual synchronous generator (VSG) has recently drawn considerable attention. VSGs are expected to enhance the frequency regulation capability of the local power grid, especially the AC microgrid in island mode. However, the cost of that performance promotion is potential instability. In this paper, the unstable phenomena of the islanded microgrid dominated by SGs and distributed generators (DSs) are addressed after mathematical modeling and detailed eigenvalue analyses respectively. The influence of VSG key parameters, e.g., virtual inertia, damping factor, and droop coefficient on system stability is investigated, and the corresponding mathematical calculation method of unstable region is obtained. The theoretical analysis is well supported by time domain simulation results. The predicted frequency oscillation suggests the consideration of stability constrain during the VSG parameters design procedure.
Feasibility of Cognitive Training in Combination With Transcranial Direct Current Stimulation in a Home-Based Context (TrainStim-Home): study protocol for a randomised controlled trial

Introduction With the worldwide increase of life expectancy leading to a higher proportion of older adults experiencing age-associated deterioration of cognitive abilities, the development of effective and widely accessible prevention and therapeutic measures has become a priority and challenge for modern medicine. Combined interventions of cognitive training and transcranial direct current stimulation (tDCS) have shown promising results for counteracting age-associated cognitive decline. However, access to clinical centres for repeated sessions is challenging, particularly in rural areas and for older adults with reduced mobility, and lack of clinical personnel and hospital space prevents extended interventions in larger cohorts. A home-based and remotely supervised application of tDCS would make the treatment more accessible for participants and relieve clinical resources. So far, studies assessing feasibility of combined interventions with a focus on cognition in a home-based setting are rare. With this study, we aim to provide evidence for the feasibility and the effects of a multisession home-based cognitive training in combination with tDCS on cognitive functions of healthy older adults. Methods and analysis The TrainStim-Home trial is a monocentric, randomised, double-blind, placebo-controlled study. Thirty healthy participants, aged 60–80 years, will receive 2 weeks of combined cognitive training and anodal tDCS over left dorsolateral prefrontal cortex (target intervention), compared with cognitive training plus sham stimulation. The cognitive training will comprise a letter updating task, and the participants will be stimulated for 20 min with 1.5 mA. The intervention sessions will take place at the participants’ home, and primary outcome will be the feasibility, operationalised by two-thirds successfully completed sessions per participant. Additionally, performance in the training task and an untrained task will be analysed. Ethics and dissemination Ethical approval was granted by the ethics committee of the University Medicine Greifswald. Results will be available through publications in peer-reviewed journals and presentations at national and international conferences. Trial registration number NCT04817124.
Poorer prospective memory performance is associated with reduced time monitoring among OEF/OIF/OND Veterans with a history of blast-related mild traumatic brain injury

Abstract Objective:Prospective memory (PM) or “remembering to remember” has been shown to be reduced in Veterans with histories of mild traumatic brain injury (mTBI), particularly on tasks with high strategic demands such as recalling time-based information in the absence of external cues. This study examined whether time monitoring during a PM task was reduced in Veterans with a history of mTBI and was associated with time-based PM performance. Method:Veterans with a history of mTBI (n = 49) and Veterans without a history of TBI (n = 16) completed the Memory for Intentions Screening Test (MIST) as a measure of PM during which their time monitoring (i.e. number of clock checks) was recorded. Results:Adjusting for age, education, depression, and PTSD symptoms, negative binomial regression revealed that the mTBI group checked the clock less frequently compared to the control group (Cohen’s d = 0.84, p = 0.005). Within the mTBI group, less frequent time monitoring across the entire MIST task was associated with poorer time-based MIST performance (r s = .57, p < 0.001), but not with event-based MIST (r s = .04, p = 0.768). Conclusions:Veterans with a history of mTBI evidenced significantly reduced time monitoring during a PM task compared to Veterans without a history mTBI, which was associated with strategically-demanding PM. Current findings provide that mTBI-associated difficulties with strategic aspects of PM may be due to reduced time monitoring. Future studies are needed to determine if reduced time monitoring also contributes to mTBI-associated PM difficulties in the real-world (e.g. medication non-adherence).
New Ameloblastoma Cell Lines Enable Preclinical Study of Targeted Therapies

Ameloblastoma (AB) is an odontogenic tumor that arises from ameloblast-lineage cells. Although relatively uncommon and rarely metastatic, AB tumors are locally invasive and destructive to the jawbone and surrounding structures. Standard-of-care surgical resection often leads to disfigurement, and many tumors will locally recur, necessitating increasingly challenging surgeries. Recent genomic studies of AB have uncovered oncogenic driver mutations, including in the mitogen-activated protein kinase (MAPK) and Hedgehog signaling pathways. Medical therapies targeting those drivers would be a highly desirable alternative or addition to surgery; however, a paucity of existing AB cell lines has stymied clinical translation. To bridge this gap, here we report the establishment of 6 new AB cell lines—generated by “conditional reprogramming”—and their genomic characterization that reveals driver mutations in FGFR2, KRAS, NRAS, BRAF, PIK3CA, and SMO. Furthermore, in proof-of-principle studies, we use the new cell lines to investigate AB oncogene dependency and drug sensitivity. Among our findings, AB cells with KRAS or NRAS mutation (MAPK pathway) are exquisitely sensitive to MEK inhibition, which propels ameloblast differentiation. AB cells with activating SMO-L412F mutation (Hedgehog pathway) are insensitive to vismodegib; however, a distinct small-molecule SMO inhibitor, BMS-833923, significantly reduces both downstream Hedgehog signaling and tumor cell viability. The novel cell line resource enables preclinical studies and promises to speed the translation of new molecularly targeted therapies for the management of ameloblastoma and related odontogenic neoplasms.
Time makes histone H3 modifications drift in mouse liver

To detect the epigenetic drift of time passing, we determined the genome-wide distributions of mono- and tri-methylated lysine 4 and acetylated and tri-methylated lysine 27 of histone H3 in the livers of healthy 3, 6 and 12 months old C57BL/6 mice. The comparison of different age profiles of histone H3 marks revealed global redistribution of histone H3 modifications with time, in particular in intergenic regions and near transcription start sites, as well as altered correlation between the profiles of different histone modifications. Moreover, feeding mice with caloric restriction diet, a treatment known to retard aging, reduced the extent of changes occurring during the first year of life in these genomic regions.
Assessing Self-reported Occupational Hazards of Manure Applicators in the Upper Midwest

ABSTRACT Manure management on farms presents potential risks to human health and safety, including infectious, chemical, and physical exposures that may result in injury or fatality. Toxic gases and confined spaces are among the most common hazards. These hazards are especially salient for the Upper Midwest of the United States. This study characterizes the occupational health and safety practices and experiences of manure applicators in Minnesota. This cross-sectional study surveyed 162 commercial manure applicators about their work characteristics, safety practices, and health and safety experiences. Respondents reported an average of 17 hours per day applying manure during the busy season, which typically occurs several weeks each year. One hundred and thirty-one (90%) of 145 respondents did not regularly use gas monitors during application. Thirty-three (37%) of 90 respondents reported at least one symptom of gas exposure during manure application work. Those that worked with swine manure were more likely to report symptoms of gas exposure than those who did not work with swine (OR 9.5; CI: 2.0, 89.0). Those that had entered confined spaces were more likely to report symptoms of gas exposure than those who had not entered confined spaces (OR 4.4; CI: 0.1, 1.1). Fourteen (9%) of 150 respondents reported being injured when applying manure. Manure work can be hazardous and may be associated with injury and gas exposure. These findings offer a starting point for future research and intervention to protect and improve the health and safety of applicators.
Cesium lead iodide electrospun fibrous membranes for white light-emitting diodes

Inorganic perovskite cesium lead iodide nanocrystals (CsPbI3 NCs) are good candidates for optoelectronic devices because of their excellent properties of remarkable luminous performance (high luminous efficiency, narrow luminous spectral line), and high photoelectric conversion efficiency by using simple preparation method. But their inherent poor stability greatly limits its practical applications. In this paper, electrospinning is used to grow fibrous membranes with embedded cesium lead iodide perovskite nanocrystals (PNCs) formed in situ in a one-step process. It was found that cubic α-CsPbI3 PNCs were formed in polymer fibers, showing bright and uniform fluorescence signals. Furthermore, the water wetting angles were increased by the fibrous structure enhancing the hydrophobicity and the stability of the fibrous membranes in water. The electrospun fibrous membrane containing CsPbI3 was combined with another membrane containing CsPbBr3 under a blue light-emitting diode (LED) to create a white LED (WLED) in air successfully with CIE coordinates (0.3020, 0.3029), and a correlated color temperature of 7527 °K, indicating high purity of WLED. Our approach provides a new way to create highly stable, photoluminescent water-resistant perovskite nanocrystalline films.
Deep Learning Applications for Acute Stroke Management

Brain imaging is essential to the clinical care of patients with stroke, a leading cause of disability and death worldwide. Whereas advanced neuroimaging techniques offer opportunities for aiding acute stroke management, several factors, including time delays, inter‐clinician variability, and lack of systemic conglomeration of clinical information, hinder their maximal utility. Recent advances in deep machine learning (DL) offer new strategies for harnessing computational medical image analysis to inform decision making in acute stroke. We examine the current state of the field for DL models in stroke triage. First, we provide a brief, clinical practice‐focused primer on DL. Next, we examine real‐world examples of DL applications in pixel‐wise labeling, volumetric lesion segmentation, stroke detection, and prediction of tissue fate postintervention. We evaluate recent deployments of deep neural networks and their ability to automatically select relevant clinical features for acute decision making, reduce inter‐rater variability, and boost reliability in rapid neuroimaging assessments, and integrate neuroimaging with electronic medical record (EMR) data in order to support clinicians in routine and triage stroke management. Ultimately, we aim to provide a framework for critically evaluating existing automated approaches, thus equipping clinicians with the ability to understand and potentially apply DL approaches in order to address challenges in clinical practice. ANN NEUROL 2022;92:574–587
Lower Extremity Somatosensory Function Throughout Concussion Recovery: A Prospective Cohort Study

Objective: Balance impairments may suggest somatosensory disruption beyond concussion clinical recovery, but somatosensory subsystems have never been directly assessed. Our objective was to examine somatosensory function between individuals with a concussion and healthy matched-controls at acute (<7 days) and asymptomatic (<72 hours of being symptom-free) time points. Setting: Laboratory. Participants: Participants with a concussion and matched controls (n = 24; 58% male, age: 19.3 ± 1.1 years, mass: 70.3 ± 16.4 kg, height: 177.3 ± 12.7 cm). Design: Prospective cohort. Main Measures: Somatosensory assessments on the dominant limb at both time points included: (1) plantar touch sensation threshold via Semmes-Weinstein monofilaments, (2) plantar pressure pain threshold via algometry, and (3) knee absolute passive joint repositioning (PJR) error via Biodex across 3 arcs (105°-75°, 30°-60°, 90°-45° knee-flexion). We used mixed-model analyses of variance, post hoc Tukey honestly significant difference t tests with mean difference, 95% CI, and Hedges' g effect sizes to examine outcomes. Results: Touch sensation had a group effect with the concussion cohort needing 0.95 grams of force (gf) more relative to controls (95% CI: 0.03 to 1.87; P = .043). No touch sensation interaction was present, but medium and large effects were observed for greater gf needed among the concussed cohort at the acute (1.11 gf; 95% CI: 0.17 to 2.05; g = 0.96) and asymptomatic time points (0.79 gf; 95% CI: −0.15 to 1.73; g = 0.73). No plantar pressure pain threshold effects were observed (P ≥ .311), with negligible pressure difference magnitudes at the acute (0.26 pound force [lbf]/cm2; 95% CI: −1.54 to 2.06; g = 0.13) and medium magnitudes at the asymptomatic time points (0.99 lbf/cm2; 95% CI: −0.81 to 2.80; g = 0.42) for the concussed cohort needing more pressure to detect pain. The 30° to 60° PJR had a time effect, with asymptomatic time point having 3.12° better accuracy (95% CI: 1.23° to 5.02; P = .002). The concussed cohort had small-to-medium magnitude differences relative to controls at the acute time point for PJR during 105° to 75° (0.89°; g = 0.30) and 90° to 45° (0.62°; g = 0.17), but not 30° to 60° (−1.75°; g = −0.40). Conclusions: Individuals with a concussion exhibited large effects for diminished plantar touch sensation and small to medium effects for inhibited plantar pressure pain sensation compared with controls, which may indicate altered somatosensory function. Negligible PJR differences suggest knee joint position sense is not altered post-concussion. Pre- and postconcussion examination is warranted to understand causal somatosensory mechanisms.
Patellofemoral joint load and knee abduction/adduction moment are sensitive to variations in femoral version and individual muscle forces

Torsional profiles of the lower limbs, such as femoral anteversion, can dictate gait and mobility, joint biomechanics and pain, and functional impairment. It currently remains unclear how the interactions between femoral anteversion, kinematics, and muscle activity patterns contribute to joint biomechanics and thus conditions such as knee pain. This study presents a computational modeling approach to investigating the interactions between femoral anteversion, muscle forces, and knee joint loads. We employed an optimal control approach to produce actuator and muscle‐driven simulations of the stance phase of gait for femoral anteversion angles ranging from −8° (retroversion) to 52° (anteversion) with a typically developing baseline of 12° of anteversion and implemented a Monte Carlo analysis for variations in lower limb muscle forces. While total patellofemoral joint load decreased with increasing femoral anteversion, patellofemoral joint load alignment worsened, and knee abduction/adduction magnitude increased with both positive and negative changes in femoral anteversion (p < 0.001). The rectus femoris muscle was found to greatly influence patellofemoral joint loads across all femoral anteversion alignments (R > 0.8, p < 0.001), and the medial gastrocnemius was found to greatly influence knee abduction/adduction moments for the extreme version cases (R > 0.74, p < 0.001). Along with the vastus lateralis, which decreased with increasing femoral anteversion (R = 0.89, p < 0.001), these muscles are prime candidates for future experimental and clinical efforts to address joint pain in individuals with extreme femoral version. These findings, along with future modeling efforts, could help clinicians better design treatment strategies for knee joint pain in populations with extreme femoral anteversion or retroversion.
The link between task-focused care and care beyond technique: A meta-ethnography about the emotional labour in nursing care.

OBJECTIVE To synthesise the available body of qualitative work regarding the experiences of registered nurses and nursing students in managing emotional demands of care. BACKGROUND Care is the central part of nursing, and its provision is linked to interaction with patients. Comprehensive care allows emotions to be considered as an essential part of care. However, the emotional commitment that care demands poses a challenge for the nursing staff. DESIGN Noblit and Hare's interpretive meta-ethnography, which was written and reviewed for reporting clarity using the eMERGe. METHODS A comprehensive systematic search strategy was undertaken in PubMed, CINAHL, Scopus, Web of Science and PsycINFO in January 2020. The search included terms related to the sample population, phenomenon of interest, purpose of the study and type of research. Original or mixed qualitative articles in English, Spanish and Portuguese were included if they addressed the emotional labour experiences of nurses or nursing students. RESULTS A line-of-argument synthesis based on the metaphor The link between task-focused care and care beyond technique was developed. Three themes from analogous and refutational translations of findings in the included nine papers emerged: (1) forces to get involved in care; (2) the cost of caring and (3) need to vent. CONCLUSION Nursing staff and students managed the emotional demands by adjusting their involvement in care. Care beyond technique is provided by nurses who have strength and motivation in themselves and in the interaction with patients to become emotionally involved in care. Task-focused care avoids emotional exposure to patient suffering due to the personal cost involved. Venting and distancing are required to emotionally reconstruct themselves and to re-engage in care. RELEVANCE TO CLINICAL PRACTICE Increased knowledge about these experiences may raise awareness of the emotional demands as part of the care process, to prevent their impact and favour their support.
10 Imaging in Myopia

© The Author(s) 2020 M. Ang, T. Y. Wong (eds.), Updates on Myopia, https://doi.org/10.1007/978-981-13-8491-2_10 Q. V. Hoang Singapore Eye Research Institute, Singapore, Singapore Singapore National Eye Centre, Singapore, Singapore Eye Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore Department of Ophthalmology, Harkness Eye Institute, Columbia University Medical Center, New York, NY, USA J. Chua Singapore Eye Research Institute, Singapore, Singapore Singapore National Eye Centre, Singapore, Singapore Eye Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore M. Ang Singapore Eye Research Institute, Singapore, Singapore Singapore National Eye Centre, Singapore, Singapore Eye Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore Myopia Centre, Cornea and Refractive Service, Singapore National Eye Centre, Singapore, Singapore L. Schmetterer (*) Singapore Eye Research Institute, Singapore, Singapore Singapore National Eye Centre, Singapore, Singapore Eye Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore Department of Ophthalmology, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, Singapore Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria e-mail: leopold.schmetterer@seri.com. sg 10 Imaging in Myopia
Poor clinical outcome of elderly patients with primary plasma cell leukemia treated with novel agents: real-world experience

Masuho Saburi, Masanori Sakata, Hiroyuki Takata, Yasuhiko Miyazaki, Katsuya Kawano, Hitohiro Sasaki, Miyuki Abe, Kazuhiro Kohno, Yasuhiro Soga, Kentaro Nagamatsu, Keiji Ono, Toshiyuki Nakayama and Eiichi Ohtsuka Department of Hematology, Oita Prefectural Hospital, Oita City, Japan; Department of Clinical Laboratory Technology, Oita Prefectural Hospital, Oita City, Japan; Department of Hematology, Oita Kouseiren Tsurumi Hospital, Japan; Department of Clinical Laboratory, Oita Kouseiren Tsurumi Hospital, Japan; Department of Hematology, Almeida Memorial Hospital, Oita, Japan
Agent-based modeling 2.0: Data-driven selection of model structure

Agent-based modeling is useful to simulate the human role in socio-technical systems. Thereby, the complexity of such systems can be captured. For instance, it has shown to be useful at simulating innovation in socio-technical systems. We develop a next step in which laborious model building is automated. We present a working example on innovation diffusion leading to consumers changing their heating behavior.
Quercetin Ameliorates XIAP Deficiency Associated Hyperinflammation.

XIAP deficiency is a rare inborn error of immunity. XIAP deficiency causes hyperinflammatory disease manifestations due to dysregulated TNF-receptor signaling and NLRP3 inflammasome function. Safe and effective long-term treatments are needed, and are especially important to help prevent the need for high-risk allogeneic hematopoietic cell transplantation. Here we evaluated inflammasome inhibitors as potential therapeutics with a focus on the natural flavonoid antioxidant quercetin. Bone marrow derived macrophages were derived from XIAP deficient or wild type (WT) mice. Human monocytes were obtained from control or XIAP deficient patients. Cells were stimulated with TLR-agonists or TNF-α +/- inhibitors or quercetin. For in vivo LPS challenge experiments, XIAP deficient or WT mice were fed mouse chow +/- supplemental quercetin (50mg/kg/day exposure) for 7 days followed by challenge with 10ng/kg LPS. IL-1β and IL-18 were measured by ELISA. In murine studies, quercetin prevented IL-1β secretion from XIAP KO cells following TLR-agonists or TNF-α stimulation (p<0.05) and strongly reduced constitutive production of IL-18 by both WT and XIAP deficient cells (p<0.05). At 4 hours following in vivo LPS challenge, blood levels of IL-1β and IL-18 were significantly decreased in mice that had received quercetin-supplemented chow (p<0.05). In experiments using human cells, quercetin greatly reduced IL-1β secretion by monocytes following TNF-α stimulation (p<0.05). Our data suggest that quercetin may be an effective natural therapeutic for the prevention of XIAP deficiency-associated hyperinflammation. Clinical trials, including careful pharmacokinetic and pharmacodynamic studies to ensure that effective levels of quercetin can be obtained, are warranted.