Miracle-dz/UniFAR-FTUs huggingface dataset:
Visualizable vs. standard, non-visualizable steerable sheath for pulmonary vein isolation procedures: Randomized, single-centre trial

Introduction Steerable sheaths (SSs) are frequently used to improve catheter contact during pulmonary vein isolation (PVI) procedures. A new type of visualizable (by electroanatomical mapping system) SS has become available in clinical treatment. Purpose We aimed to compare procedural data of visualizable vs. non-visualizable steerable sheath assisted PVI procedures in patients with atrial fibrillation (AF). Methods In this single-centre randomized study, we enrolled a total of 100 consecutive patients who underwent PVI due to AF. Results A total of 100 patients were randomized into 2 groups (visualizable SS group: 50; non-visualizable SS group: 50). Acute ablation success was 100% and the rate of the first pass isolation were similar (92% vs. 89%; p = 0.88). Using visualizable SS, left atrial (LA) procedure time (53.1 [41.3; 73.1] min vs. 59.5 [47.6; 74.1] min.; p = 0.04), LA fluoroscopy time (0 [0; 0] s vs. 17.5 [5.5; 69.25] s; p < 0.01) and LA fluoroscopy dose (0 [0; 0.27] mGy vs. 0.74 [0.16; 2.34] mGy; p < 0.01) was significantly less, however, there was no difference in the total procedural time (90 ± 35.2 min vs. 99.5 ± 31.8 min; p = 0.13), total fluoroscopy time (184 ± 89 s vs. 193 ± 44 s; p = 0.79), and total fluoroscopy dose (9.12 ± 1.98 mGy vs. 9.97 ± 2.27 mGy; p = 0.76). Compared to standard, non-visualizable SS group, the number of radiofrequency ablations was fewer (69 [58; 80] vs. 79 [73; 86); p < 0.01) as well as total ablation time was reduced (1049 sec. [853; 1175] vs. 1265 sec. [1085; 1441]; p < 0.01) in the visualizable SS cohort. No major complications occurred in either group. Conclusion Compared to the standard, non-visualizable SS, visualizable SS significantly reduces the left atrial procedure time, RF delivery and fluoroscopy exposure without compromising its safety or effectiveness in patients undergoing PVI procedures for AF. Graphical Abstract Using visualizable or non-visualizable steerable sheaths for pulmonary vein isolation.
Thermal Management of On-Chip Hot Spot

The rapid emergence of nanoelectronics, with the consequent rise in transistor density and switching speed, has led to a steep increase in microprocessor chip heat flux and growing concern over the emergence of on-chip “hot spots”. The application of on-chip high heat flux cooling techniques is today a primary driver for innovation in the electronics industry. In this paper, the physical phenomena underpinning the most promising on-chip thermal management approaches for hot spot remediation, along with basic modeling equations and typical results are described. Attention is devoted to thermoelectric microcoolers — using mini-contcat enhancement and in-plane thermoelectric currents, orthotropic TIM’s/heat spreaders, and phase-change microgap coolers.Copyright © 2009 by ASME
In situ X–ray diffraction study of the phase boundary between diaspore and δ–AlOOH

To determine the phase boundary between diaspore ( α – AlOOH) and δ – AlOOH, in situ X – ray di ﬀ raction experiments were carried out using a multi – anvil high – pressure apparatus and synchrotron X – ray. The stability of each phase was determined by observing the change in powder X – ray di ﬀ raction patterns. The equilibrium phase boundary is described by the formula P (GPa) = 12.2 (±4.9) + 0.0027 (±0.0044) × T (K). The boundary determined in this study is located at a lower pressure than that estimated by previous quenching experimental studies.
El aprendizaje colaborativo en el aula virtual en tiempo de pandemia ‘Plan padrino’

Hoy en día, los ambientes académicos han cambiado por la situación de pandemia desencadenada por el COVID-19, lo que ha llevado a que las prácticas virtuales sean una prioridad para propiciar los espacios de aprendizaje en el aula, dirigidos a los estudiantes. Si bien es cierto que esos espacios deben favorecer el desarrollo de un aprendizaje consciente, significativo y cooperativo para beneficiar la comunicación y la interacción entre estudiantes y también entre estudiantes como grupo y docentes, es importante tener en cuenta que, llevar este proceso de aprendizaje en tiempos de pandemia no es una tarea fácil, ya que se debe promover en cada uno de los estudiantes, ambientes y escenarios que generen motivación permanente y atención para el desarrollo de cada una de las clases propuestas. Bajo este entendimiento, reflexionaremos sobre la estrategia de enseñanza entre pares, desde el quehacer pedagógico docente.
A System Level FMCW RADAR Optimization For Automotive Powertrain Control Application Requirements

A full system level analysis, design, and realization of frequency-modulation / continuouswave (FMCW) RADAR is presented in this thesis. RADAR technology has been around for over half a century, and has found itself in a wide range of applications effecting every day life. As such, there are many possible system level tradeoffs that can be made when designing a sensor for a specific application. This paper will focus on designing a sensor for a hybrid electric vehicle powertrain control unit, as part of a new application in fuel economy improvement. The system level analysis will derive a full baseband signal analysis model, and examine some of the commonly used modulation schemes. Next, a method for tuning the modulation waveform properties to optimize the sensor specifically for the application requirements is presented. Finally a system level realization is proposed to produce synchronous and streamlined processing of the signals, while providing flexibility to tune the implementation as suggested during the modulation waveform optimization. As a proof of concept, a hardware prototyping platform was designed and built to allow acquisition of real signals which are to be fed into a signal processing algorithm. The signal processing algorithm to decode the measurement results can then be developed effectively using real data. Some of the measurement results obtained with the prototyping platform and system optimizations suggested within this thesis are presented to verify the analysis and modeling performed.
Evaluación de rasgos de inteligencia emocional en estudiantes normalistas de la ciudad de Pasto

Este artículo presenta la evaluación de los rasgos de la inteligencia emocional a 172 estudiantes del Ciclo de Formación Complementaria de la Institución Educativa Escuela Normal Superior de Pasto. El instrumento para la recolección de información fue la escala TMMS-24, a través de la cual se determinó el nivel de atención emocional, claridad emocional y reparación emocional; fue digitalizada mediante formulario de Google Forms para desarrollar el proyecto durante la época de prevención por la pandemia de COVID-19. La investigación, desarrollada desde el paradigma cuantitativo, asume un alcance descriptivo. Los resultados demuestran niveles adecuados de atención a los sentimientos, niveles bajos de claridad emocional y niveles bajos de reparación emocional. Además, se concluye que las mujeres presentan mayor nivel de inteligencia emocional en comparación con los hombres.
Antagonizing Glutamine Bioavailability Promotes Radiation Sensitivity in Prostate Cancer

Simple Summary Radiation is the standard of care for prostate cancer, but almost half the patients develop resistant disease. It is imperative to understand the reasons behind disease progression to develop more effective strategies of treatment. We determined that glutamine is a crucial nutrient in driving prostate cancer tumors as people with more glutamine have poorer outcomes. We hypothesized that directly depriving cancer cells of this precious resource will further sensitize them to radiation. We sought to repurpose the drug L-asparaginase, which has been used extensively to treat leukemia patients, to complement radiation therapy for prostate cancer patients. This drug depletes glutamine in the blood and hinders an aspect of cell growth that makes cancer cells that are otherwise resistant vulnerable to irradiation. Ultimately, mouse models of prostate cancer given L-asparaginase in combination with irradiation were more effective at reducing tumor size than radiation alone. Abstract Nearly half of localized prostate cancer (PCa) patients given radiation therapy develop recurrence. Here, we identified glutamine as a key player in mediating the radio-sensitivity of PCa. Glutamine transporters and glutaminase are upregulated by radiation therapy of PCa cells, but respective inhibitors were ineffective in radio-sensitization. However, targeting glutamine bioavailability by L-asparaginase (L-ASP) led to a significant reduction in clonogenicity when combined with irradiation. L-ASP reduced extracellular asparagine and glutamine, but the sensitization effects were driven through its depletion of glutamine. L-ASP led to G2/M cell cycle checkpoint blockade. As evidence, there was a respective delay in DNA repair associated with RAD51 downregulation and upregulation of CHOP, contributing to radiation-induced cell death. A radio-resistant PCa cell line was developed, was found to bypass radiation-induced mitotic catastrophe, and was sensitive to L-ASP/radiation combination treatment. Previously, PCa-associated fibroblasts were reported as a glutamine source supporting tumor progression. As such, glutamine-free media were not effective in promoting radiation-induced PCa cell death when co-cultured with associated primary fibroblasts. However, the administration L-ASP catalyzed glutamine depletion with irradiated co-cultures and catalyzed tumor volume reduction in a mouse model. The clinical history of L-ASP for leukemia patients supports the viability for its repurposing as a radio-sensitizer for PCa patients.
A project management approach for a mining stope

Continuously increasing costs and weakening commodity prices have forced mining companies to focus on improving their efficiency in order to enhance production rates. Because of this, more companies are treating their daily mining operations as a project for the purpose of achieving this goal. This paper focuses on an underground stoping panel project where platinum group metals (PGMs) are extracted using conventional drill-and-blast mining methods. A conventional stope can be classified as a project due to its uncertain and unpredictable characteristics, many variations, and a large number of interdependencies. These interdependencies may be minor linked activities with characteristics that tend to increase the risk of failure. The ’project management approach’ to be applied to this case study should consider the risks associated with each event and be able to serve as a method to avoid disruption caused by unforeseen events. In project management, specific methods are applied to achieve objectives. In this study the critical chain project management (CCPM) approach and the event chain project management (ECPM) approach are compared to determine which is more applicable for use in an underground stope. The aim is to improve the efficiency of day-to-day stoping activities using a project management approach. The day-to-day operations are guided by a definite goal – achieving the most effective blast. This approach will improve project planning, therefore assisting in preparation for any uncertainty.
Oxidative Stress in Type 2 Diabetes and The Impact of Exercise: from mitochondria to glucose management in skeletal muscle

Oxidative stress is the result of reactive oxygen species (ROS) overproduction and/or a decline in antioxidant defense mechanisms. Oxidative stress can be marked by deleterious effects on DNA, proteins, and lipids structure, changing cell homeostasis, and contributing to the development of metabolic diseases as type two diabetes (T2D), characterized mainly by insulin resistance in several tissues, as skeletal muscle. The T2D development and its complications are related to mitochondrial dysfunction and oxidative stress, as well as pro-inflammatory state and metabolic unbalance. Acute exercise represents a necessary type of challenge to whole-body homeostasis. Therefore, regular exercise (sum of acute exercise challenges) promotes antioxidant, anti-inflammatory, and metabolic adaptations induced by each stress induced by the exercise session, evoking a hormesis effect (from mitochondria to many tissues) that is beneficial for T2D prevention and treatment. Despite of a considerable research information in the field, the characterization of the sources and pathways of ROS generation in T2D and during exercise still a matter for investigation. Therefore, the multifaceted effects of oxidative stress in T2D and the link of exercise in T2D are discussed in this review.
Clinical Application Effects of Different Preoperative Blood Management Schemes in Older Patients with Delayed Intertrochanteric Fracture Surgery

Introduction Research on preoperative blood management in older patients with delayed surgery for intertrochanteric fracture is scarce, especially regarding hematopoiesis and hemostasis. We assessed the effectiveness of optimized blood management programs in older patients undergoing delayed surgery for intertrochanteric fractures. Methods This retrospective study included 456 patients who underwent delayed surgery for intertrochanteric fractures. According to the optimized blood management plan, the patients were divided into four groups: group A was the control group; group B received 1 g of tranexamic acid (TXA) intravenously at admission; group C underwent sequential TXA treatment after admission until 1 day before surgery (1 g/day); and group D received iron supplements (200 mg/day) in addition to the treatment administered to group C, with or without recombinant human erythropoietin (rHuEPO; 40,000 IU). The primary outcomes were preoperative hidden blood loss (HBL), preoperative allogeneic blood transfusion (ABT) rate, hemoglobin (Hb) change, and actual Hb drop. Results The Hb reduction, calculated HBL, and hospitalization duration in groups C and D were significantly lower than those in groups A and B. The preoperative ABT rates in groups C and D were significantly lower than those in groups A and B, with no significant difference between groups C and D. Discussion The results of this study suggested that iron supplementation (with or without rHuEPO) combined with the sequential IV TXA scheme did not show a better clinical effect than the sequential IV TXA scheme in the management of patients undergoing delayed surgery for intertrochanteric fractures. Therefore, further evaluation is needed before recommending iron supplements and rHuEPO in older patients.
Association of health problems with 50 Hz magnetic fields in human adults living near power transmission lines

Although numerous studies of animals and cell cultures indicate effects of power-frequency magnetic fields on immune system function, few studies have looked for evidence of association between environmental power-frequency magnetic field exposure and immune- related illnesses in humans. This study used a cross sectional design to examine the dose-response relationship between magnetic field exposure of adults in their homes and prevalence of immune-related and other chronic illnesses. Five hundred and sixty adults living near extra high voltage transmission lines completed questionnaires about their health and demographic characteristics. Derived health variables were related to individual estimates of time integrated magnetic field exposure. Five of the eight health variables showed a linear dose- response relationship with exposure. After adjustment for possible confounding, significantly elevated odds ratios were obtained at higher exposure levels both for asthma and for combined chronic illnesses. The results are consistent with a possible adverse effect of environmental magnetic field exposure on immune-related and other illnesses. (author abstract)
Process of Investigation onCriminal Actions of Fake Reports by the Reserse & Criminal Unit Investigators to Prosecutor

The aim of this research is to find out and analyze the process of investigating criminal acts of false reports by investigators from the Criminal Investigation Unit to the prosecutor's office. To find out and analyze the obstacles to the process of investigating criminal acts of false reports by investigators from the Criminal Investigation Unit to the prosecutor's office. To find out and analyze efforts to overcome obstacles to the process of investigating criminal acts of false reports by investigators from the Criminal Investigation Unit to the prosecutor's office. This study uses a sociological juridical approach, with descriptive analytical research specifications. The data used in this research is secondary data obtained through literature study which is then analyzed qualitatively. The results of this study are the Process of Investigating False Reports by Criminal Investigation Unit Investigators to the Prosecutor's Office is an investigator who submits a case file or the result of the report turns out to be false to the prosecutor's office, the prosecutor can return the case file or the results of the report to the investigator with instructions or directions from the prosecutor. Its office with coordination or cooperation between the police and the prosecutor's office. The resistance is the investigation of a criminal act of a false report takes a long time: in handling a criminal act of a false report by a defendant, it cannot be processed further if it only relies on information/confessions from the suspect, and if the case related to the crime of a false report has not been revealed or proven. Proving is difficult, it is difficult to prove the case in the investigation because in fact this case does not exist so that investigators must be more observant and patient in every collection of evidence. The solution is intensify every report or input from everyone about everything related to the problem of the crime of the false report. Increased awareness of new modes of crime.
Prognostic properties of the association between the S-100B protein levels and the mean cerebral blood flow velocity in patients diagnosed with severe traumatic brain injury

Craniocerebral injury (CBI) is tissue damage caused by a sudden mechanical force. CBI can result in neurological, neuropsychological and psychiatric dysfunctions. Currently, the severity of CBI is assessed using the Glasgow Coma Scale, brain perfusion pressure measurements, transcranial Doppler tests and biochemical markers. This study aimed to determine the applicability of the S-100B protein levels and the time-averaged mean maximum cerebral blood flow velocity (Vmean) as a means of predicting the treatment outcomes of CBI in the first 4 days of hospitalization. The results validated the standard reference ranges previously proposed for the concentration of S-100B (0.05-0.23 µg/l) and the mean of cerebral blood flow velocity (30.9 to 74.1 cm/sec). The following stratification scheme was used to predict the success of treatment: Patients with a Glasgow Outcome Scale (GOS) score ≥4 or GOS <4 were stratified into ‘favorable’ and ‘unfavorable’ groups, respectively. The favorable group showed relatively constant levels of the S-100B protein close to the normal range and exhibited an increase in Vmean, but this was still within the normal range. The unfavorable group exhibited a high level of S-100B protein and increased Vmean outside of the normal ranges. The changes in the levels of S-100B in the unfavorable and favorable groups were -0.03 and -0.006 mg/l/h, respectively. Furthermore, the rate of decrease in the Vmean value in the unfavorable and favorable groups were -0.26 and -0.18 cm/sec/h, respectively. This study showed that constant levels of S-100B protein, even slightly above the normal range, associated with an increase in Vmean was indicative of a positive therapeutic outcome. However, additional research is required to obtain the appropriate statistical strength required for clinical practice.
Body Temperature Measurement Reveals the Reproductive Profile of Female Apodemus speciosus under Laboratory and Field Conditions

Abstract. This study illustrated body temperature (Tb) fluctuation during reproduction and discussed the effectiveness of measuring Tb for predicting the reproductive profile of female Apodemus speciosus both under laboratory and field conditions. Tb fluctuation was monitored for four breeding events in the laboratory and for three in the field. Individual variation in Tb fluctuation during reproduction was larger in the field than in the laboratory, while its temporal pattern was clearer in the field than in the laboratory. Tb fluctuating patterns according to the progress of the reproductive stage were similar between the laboratory and the field. Daily mean Tb increased after the start of pregnancy, decreased during late pregnancy, rapidly increased after parturition, and remained higher through the lactation period. In particular, the following three characteristics should be apparent indices of parturition: increase of daily mean Tb and daily minimum Tb in early pregnancy, decrease of daily max Tb and daily mean Tb in late pregnancy, and increase of daily max Tb at the day of parturition. These results indicate that implanting small-sized loggers enables us to obtain a representative pattern of Tb fluctuation and to predict the reproductive profile of female A. speciosus, both under laboratory and field conditions.
Deep Reinforcement Learning-Based Routing and Spectrum Assignment of EONs by Exploiting GCN and RNN for Feature Extraction

Deep reinforcement learning (DRL) has been introduced to the routing and spectrum assignment (RSA) of elastic optical networks (EONs) where the RSA policies are learnt during the interaction of a DRL agent with the EON environment. Upon each new traffic arrival, the DRL agent senses the EON state, and makes the RSA decision accordingly. Therefore, the EON state feature extraction is essential for the performance. However, current approaches, mainly based on fully connected neural networks or convolutional neural networks, are unsatisfactory in EON state feature extraction due to the following two reasons. (1) The optical network topology information is not well considered. (2) The path-level features are highly related to the RSA decision, due to the spectrum continuity constraint, while path-level feature extraction has not been well exploited. To overcome the above shortcomings, in this paper, we propose to utilize the Graph Convolutional Neural Network (GCN) and the Recurrent Neural Network (RNN) for the feature extraction of the network topology, and the aggregation of link-level features to path-level features. By doing this, critical RSA-related information can be sensed by the DRL agent to make better actions. Simulation results demonstrate that our proposed method outperforms previous approaches.
Automating data collection methods in electronic health record systems: a Social Determinant of Health (SDOH) viewpoint

ABSTRACT Social Determinant of Health (SDOH) data are important targets for research and innovation in Health Information Systems (HIS). The ways we envision SDOH in “smart” information systems will play a considerable role in shaping future population health landscapes. Current methods for data collection can capture wide ranges of SDOH factors, in standardised and non-standardised formats, from both primary and secondary sources. Advances in automating data linkage and text classification show particular promise for enhancing SDOH in HIS. One challenge is that social communication processes embedded in data collection are directly related to the inequalities that HIS attempt to measure and redress. To advance equity, it is imperative thatcare-providers, researchers, technicians, and administrators attend to power dynamics in HIS standards and practices. We recommend: 1. Investing in interdisciplinary and intersectoral knowledge generation and translation. 2. Developing novel methods for data discovery, linkage and analysis through participatory research. 3. Channelling information into upstream evidence-informed policy.