Miracle-dz/UniFAR-FTUs huggingface dataset:
SURVIVAL OF MICROORGANISMS FROM MODERN PROBIOTICS IN MODEL CONDITIONS OF THE INTESTINE

discussion. After incubation in a simulated gastric environment, bacteria of the type Lactobacillus and Bifidobacterium did not survive and were not defined. Only Bacillus coagulans and Saccharomyces boulardii were resistant. These microorganisms grew after incubation in the same amount as before incubation - 10 5-6 and 10 7-8 CFU respectively. Bacillus clausii also survived in these conditions, but to a lesser extent: initially - 10 7 CFU, after incubation - 10 5 CFU. After staying in model environment of the duodenum Bacillus coagulans and Saccharomyces boulardii were still fully viable, and the number of germinating Bacillus clausii bacteria decreased by an order - up to 10 4 CFU. Conclusion. The probiotics containing Bacillus coagulans and Saccharomyces boulardii showed complete resistance to the impact of the model environment of the stomach and duodenum, Bacillus clausii was partially resistant. It leads to conclusion that probiotic drugs containing lactobacilli and bifidobacteria, cannot withstand the aggressive environmental influence of the stomach and duodenum and become inactivated under their influence. Probiotic drugs Enterol containing yeast Saccharomyces boulardii , and Laktovit Forte containing the spore-forming bacterium Bacillus coagulans are completely resistant to the action of the model environment of the stomach and duodenum.
Aggregation and the Law of Large Numbers in Economies with a Continuum of Agents

This paper develops a framework in which a model with a continuum of agents and with individual and aggregate risks can be viewed as an idealization of large finite economies. The paper identifies conditions under which a sequence of finite economies gives rise to a limiting continuum economy in which uncertainty has a simple structure. The state space is the product of aggregate states and micro-states; aggregate states represent economy-wide random aggregate fluctuations, while micro-states reflect individual shocks which fluctuate independently around aggregate states and have no further discernible structure. In the special case where shocks in the finite economies are exchangable, the limiting economy satisfies a continuum-version of de Finetti's Theorem. The paper then uses this framework to derive implications for the interpretations of the Strong Law of Large Numbers and the Pettis Integral.
Introductory Chapter: Hair Loss Introductory Chapter: Hair Loss

Hair loss (alopecia) is a prevalent dermatological course and it has an impact on both females and males of all ages. For centuries, hair has been the most important sign for the females. Healthy hair is an essential factor for physical well‐being and females can show their charm, beauty and personal power with healthy hair. That is why hair loss can cause psychological problems for women rather than for men.
Fluxes of Ca 2 (cid:2) and K (cid:2) Are Required for the Listeriolysin O-Dependent Internalization Pathway of Listeria monocytogenes

Listeria monocytogenes is responsible for the life-threatening food-borne disease listeriosis. This disease mainly affects elderly and immunocompromised individuals, causing bacteremia and meningoencephalitis. In pregnant women, L. monocytogenes infection leads to abortion and severe infection of the fetus or newborn. The L. monocytogenes intracellular life cycle is critical for pathogenesis. Previous studies have established that the major virulence factor of L. monocytogenes , the pore-forming toxin listeriolysin O (LLO), is sufﬁcient to induce L. monocytogenes internalization into human epithelial cell lines. This internalization pathway strictly requires the formation of LLO pores in the plasma membrane and can be stimulated by the heterologous pore-forming toxin pneumolysin, suggesting that LLO acts nonspeciﬁcally by forming transmembrane pores. The present work tested the hypothesis that Ca 2 (cid:2) and K (cid:2) ﬂuxes subsequent to perforation by LLO control L. monocytogenes internalization. We report that L. monocytogenes perforates the host cell plasma membrane in an LLO-dependent fashion at the early stage of invasion. In response to perforation, host cells undergo Ca 2 (cid:2) -dependent but K (cid:2) -independent resealing of their plasma membrane. In contrast to the plasma membrane resealing process, LLO-induced L. monocytogenes internalization requires both Ca 2 (cid:2) and K (cid:2) ﬂuxes. Further linking ion ﬂuxes to bacterial internalization, treating cells with a combination of Ca 2 (cid:2) and K (cid:2) ionophores but not with individual ionophores is sufﬁcient to induce efﬁcient internalization of large cargoes, such as 1- (cid:3) m polystyrene beads and bacteria. We propose that LLO-induced L. monocytogenes internalization requires a Ca 2 (cid:2) - and K (cid:2) -dependent internalization pathway that is mechanistically distinct from the process of plasma membrane resealing.
Higher Education, the Health Care Industry, and Metropolitan Regional Economic Development: What Can "Eds & Meds" Do for the Economic Fortunes of a Metro Area's Residents?

This paper examines the effects of expansions in higher educational institutions and the medical service industry on the economic development of a metropolitan area. This examination pulls together previous research and provides some new empirical evidence. We provide quantitative evidence of the magnitude of economic effects of higher education and medical service industries that occur through the mechanism of providing some export-base demand stimulus to a metropolitan economy. We also provide quantitative evidence on how much higher education institutions can boost a metropolitan economy through increasing the educational attainment of local residence. We estimate that medical service industries pay above average wages, holding worker characteristics constant, whereas the higher education industry pays below average wages; the wage standards of these industries may affect overall metropolitan wages. We also discuss other mechanisms by which these two industries may boost a metropolitan economy, including: increasing local amenities, generating R&D spillovers, increasing the rate of entrepreneurship in local businesses, and helping provide local leadership on development and growth issues. Finally, the paper discusses possible effects of these two industries on disparities between the central city and suburbs in a metropolitan area. JEL Classification: R58, R11, R23, R53 Paper prepared for the Conference on Urban and Regional Policy Effects, held on March 29–30, 2007, and sponsored by the George Washington University Institute of Public Policy and School of Public Policy and Administration, the Brookings Institution, and the Urban Institute. The authors appreciate the assistance of Wei-Jang Huang, Claire Black, Linda Richer, Babette Schmitt, and Julie Kurtz. We also thank Lara Shore-Sheppard, Diane Pfundstein, and David Jaeger for help in matching metro areas from the various censuses. This paper should not be construed as official views of any of the sponsors of this conference, or of the Upjohn Institute. A substantially shortened version of this paper was published in the book Urban and Regional Policy and Its Effects (Margery Austin Turner, Howard Wind, and Hal Wolman, eds.) Brookings Institution Press, 2008.
Functional photonic devices based on silicon wire waveguide

We demonstrate our recent progress in functional photonic devices based on a silicon wire waveguide. The propagation loss of the waveguide has been reduced to around 2 dB/cm, and the inorganic low-loss fiber coupling structure has been completed. For passive functions, we have developed ring resonators and apodized lattice filters for add/drop filtering devices. The ring resonators realized very high Q values of around 20,000. The lattice filters realized large free spectral range and low cross-talk. For active, or nonlinear function, we demonstrate all-optical wavelength conversion based on the four-wave-mixing effect. The conversion efficiency was -12 dB, and clear eye-patterns of the converted signal are observed at 10 Gbps operation.
An ID-based Broadcast Encryption Scheme for Cloud-network Integration in Smart Grid

The rapid growth of data has successfully promoted the development of modern information and communication technologies, which are used to process data generated by public urban departments and citizens in modern cities. In specific application areas where the ciphertext of messages generated by different users’ needs to be transmitted, the concept of broadcast encryption is important. It can not only improve the transmission efficiency but also reduce the cost. However, the existing schemes cannot entirely ensure the privacy of receivers and dynamically adjust the user authorization. To mitigate these deficiencies, we propose an efficient, secure identity-based broadcast encryption scheme that achieves direct revocation and receiver anonymity, along with the analysis of smart grid solutions. Moreover, we constructed a security model to ensure wireless data transmission under cloud computing and internet of things integrated devices. The achieved results reveal that the proposed scheme is semantically secure in the random oracle model. The performance of the proposed scheme is evaluated through theoretical analysis and numerical experiments.
Usage of Static Analysis Tools in the Integrated Development Environment

Developers make use of automation to perform repetitive and potentially errorprone tasks. One such automation can be categorised as static analysis, which aims to analyse program properties. The particular focus of this investigation are so-called ASATs (Automatic Static Analysis Tools). These ASATs are readily available for many programming languages and can be used to check coding style guidelines, elements of functional correctness and maintainability related issues. Previous studies on static analysis involved qualitative developer interviews and quantitative repository mining studies. This thesis uses automated telemetry to carry out a field study within the Integrated Development Environment (IDE), to obtain fine-grained data on developer behavior with regard to the actual use of ASATs. In addition, we have carried out a survey to validate the observed patterns. The field study is based on the Eclipse and IntelliJ plugin WatchDog, for which we elaborate upon an extensive investigation of static analysis observation techniques in the IDEs. Based on the quantitative data, we conclude the majority of all observed static analysis IDE events originate from few categories of warnings. Moreover, most of the warnings are resolved within one minute, with warnings related to type resolution being resolved the quickest. Developers corroborate these findings, but also confirm perceptions of earlier research that warnings contain large numbers of false positives. Based on both datapoints, we envision a data-driven future of static analysis tooling to optimize for usefulness for the developer rather than absolute correctness of tool implementations.
A variational representation for G-Brownian functionals

The purpose of this paper is to establish a variational representation \log \E [e^{f(B)}] = \sup_h \E [f(B + \int_0^{\cdot} d_s h_s) - 1/2 \int_0^1 h_s \cdot (d_s h_s)] for functionals of the d-dimensional G-Brownian motion B. Here \E is a sublinear expectation called G-expectation, f is any bounded function in the domain of \E mapping C([0,1];\R^d) to \R, the integrals are taken with respect to the quadratic variation of B, and the supremum runs over all h's for which these integrals are well-defined. As an application, we give another proof of the results obtained by Gao-Jiang (2010), large deviations for G-Brownian motion.
Journal of Plant Production Effect of Methyl Jasmonate, Salicylic Acid and Their Combination on Growth and Bioactive Constituents in Cichoriun intybus L.

The current study was conducted to evaluate the efficiency of seedling’s roots-feeding of the elicitor solution of methyl jasmonate (MeJ), salicylic acid (SA) and their combination as an elicitation approach for enhancing the biosynthesis of cichory’s main bioactive secondary metabolites. The long-lasting elicitation effect of both MeJ and SA was also evaluated through comparing the level of bioactive compounds in treated plants of the first harvest with those of the second one. Results indicated that MeJ, SA, and their combination decreased growth of cichory plants whereas increased their potential to biosynthesize their characteristic bioactive secondary metabolites. Shoots and roots of MeJ-, SA- and MeJ+SA-treated plants contained significantly higher contents from ascorbic acid as well as total antioxidants, total phenols as well as flavonoids and inulin compared with untreated plants of either the first or the second harvest. The effect of MeJ surpassed that of SA in inducing contents of the secondary metabolites. Control plants of the second harvest had, generally, higher contents from ascorbic acid, total antioxidants, total phenols total flavonoids and inulin compared with plants of the first harvest. It could be concluded that seedlings’ roots-feeding of the elicitor solution is feasible, easy and cost-effective approach for long-lasting elicitation effect, and that MeJ is superior to SA in eliciting cichory’s bioactive secondary metabolites.
MANAGEMENT OF HYPERTENSIVE PATIENTS WITH CARDIOVASCULAR CO MORBIDITY IN PRIMARY CARE

: Introduction: According to the current evidence and guidelines, the treatment of primary (also known as essential) hypertension is crucial to reduce the risk of cardiovascular-related complications and mortality. The WHO stated in their reports that hypertension is considered the most dangerous predisposing factor that leads to mortality and long-term morbidity in all areas of the world. They estimated that over one billion individuals around the world are hypertensive which is causing more than nine million deaths annually. Aim of work: In this review, we will discuss the most recent evidence regarding Management of hypertensive patients with cardiovascular co morbidity in primary care Methodology: We did a systematic search for Management of hypertensive patients with cardiovascular co morbidity in primary care using PubMed search engine (http://www.ncbi.nlm.nih.gov/) and Google Scholar search engine (https://scholar.google.com). We only included full articles. Conclusions: Hypertension is considered to be the most important risk factor of developing cardiovascular diseases, and an important factor leading to serious morbidity and mortality. Many patients with hypertension are considered to be high-risk patients, meaning that they have a significantly higher risk of developing cardiovascular complications due to their hypertension. These patients must follow strict management in order to decrease their risks of developing cardiovascular diseases.
Cooperation between C aenorhabditis elegans COMPASS and condensin in germline chromatin 1 organization 2

methylation at promoter regions and is associated with context-dependent effects on gene expression. Whether it also contributes to higher-order chromosome organization a quantitative FRET (Förster resonance energy transfer)-based fluorescence lifetime imaging microscopy (FLIM) approach to assay nanometer scale chromatin compaction in live animals, we reveal a novel role for SET1/COMPASS in structuring meiotic chromosomes in the C. elegans germline . Inactivation of SET-2, the C. elegans homologue of SET1, strongly enhanced chromosome organization defects and loss of fertility resulting from depletion of condensin-II, and aggravated defects in chromosome morphology resulting from inactivation of topoisomerase II, another major structural component of chromosomes. Loss of CFP-1, the chromatin targeting subunit of COMPASS, similarly affected germline chromatin compaction measured by FLIM-FRET and enhanced condensin-II knock- down phenotypes. These the SET-2 GFP-H2B FLIM using an inverted multi-photon a 40x Plan-Apochromat Two- excitation provided sub-150-fs GFP mCherry as a FRET pair. two-photon excitation excite GFP Detection lifetimes pixels field 256
Implementation of Speech Companding Technique in Blackfin Digital Signal Processor for Digital Telephone Systems

: The companding is a Pulse Code Modulation technique which can be effectively used in different applications, especially in digital telephone systems. A digital telephone system gets an analog speech input signal and it is converted into a digital signal usually it is considered as a linear signal. In order to reduce the transmission bandwidth, the signal is compressed before transmission which would become a non-linear signal. The non-linear digital signal is converted back to a linear digital signal in digital reception. The international standard A-law (G.711) is a speech companding technique, to compress 13-bits linear PCM data down to 8-bits of logarithmic data and expands 8-bits of logarithmic data back to 13-bits linear PCM data that allowing for a bit rate of 64 kbps. This A-law companding technique is implemented by using ADSP BF533 processor which is an enhanced member of the Analog Device Blackfin family that offers significantly higher performance in lower power for new product development.
Teacher Candidates' Opinions Regarding Instructional and Safe Use of Social Networks and Internet Addiction Risk Levels

– In conjunction with the development and advancement of internet technologies, social networking sites have created a socialization environment. Instructors point out that these tools must be used as an active and different form of communication with students. Also, participation of the students through social networking sites should be encouraged. However, the risk of internet addiction has also become widespread on the increase use of social networks. The aim of this research is to “determine the opinions of teacher candidates on the use of social networking sites in education and Internet addiction risk levels”. General survey model was used in this research in order to determine the opinions regarding social networks of teacher candidates from the education faculties in the Turkish Republic of Northern Cyprus and figure out their internet addiction risk levels. “Use of Social Networks in Education Scale” developed by Ozturk and Akgun and “Internet Addiction Test” developed by Young were used in this research. According to the results of the study, it has been figured out that almost all of the teacher candidates think that sharing information through social networking sites is either partially safe or not safe. Besides, most of the teacher candidates feel anxious about keeping information as confidential. Another important result is that teacher candidates are internet users at an average level. It also shows that they might spend too much time on the internet however they use internet in a controlled manner.
Theoretical Review On Integrated Reporting

: Professional accounting bodies, regulatory bodies, academics, and researchers have highlighted the importance of applying the IR practices, and the academic discussion addressing the IR phenomena proliferated. This study analyzes the perspectives of diffusion of innovation theory, institutional theory, legitimacy theory, stakeholder theory, shareholder theory, agency theory,signaling theory, and resource-based theory on the various facets of integrated reporting. This study aims to provide the panoramic theoretical understanding for the research advancement of integrated reporting by giving guidance about choosing the of most suitable theory/ies for different aspects of integrated reporting. The study concludes the theoretical rationale behind the adoption of integrated reporting practice and shows the potential avenues for future research on integrated reporting.
SDS Adsorptions Films at the H 2 O - Au (111) Interface: Molecular Dynamics Study of AFM Tip–Surface Contact

On the example of the anionic model surfactant sodium dodecyl sulphate at the idealised water- gold interface, our present molecular dynamics simulations illuminate the interdependence of adsorption ﬁlm morphology and its mechanical properties at the nanoscale. Distinct ﬁlm phases exhibit unique force response features in modelled atomic force microscopy experiments.
CMAR_A_257583 10077..10090

1Department of Otolaryngology, The First Affiliate Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People’s Republic of China; 2Department of Otolaryngology, Urumqi Eye and ENT Specialist Hospital, Urumqi, Xinjiang, People’s Republic of China Background: Radioresistance greatly hinders the treatment of nasopharyngeal carcinoma (NPC). Long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been corroborated to participate in diverse cancers, including NPC. Our aim was to investigate the underlying molecular mechanism of PVT1 in NPC radioresistance. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was utilized to measure the expression levels of PVT1, microRNA (miR)-515-5p and phosphatidylinositol4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) in NPC tissues and cells. Cell counting kit-8 (CCK8) assay, colony formation assay and flow cytometry assay were employed to detect cell proliferation, radiosensitivity and apoptosis, respectively. The protein levels of Cyclin D1, B-cell lymphoma 2 associated X (Bax), Cleaved-caspase-3, PIK3CA, protein kinase B (AKT) and phosphorylated AKT (p-AKT) in samples were measured by Western blot. The starBase was used to predict the binding sites between miR-515-5p and PVT1 or PIK3CA. Dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay were performed to verify the interaction. Xenograft tumor model was established to investigate the biological role of PVT1 in vivo. Results: The levels of PVT1 and PIK3CA were upregulated in NPC tissues and cells, opposite to the expression of miR-515-5p. Knockdown of PVT1 inhibited cell proliferation, radioresistance and promoted cell apoptosis in NPC cells. Meanwhile, PVT1 silencing downregulated Cyclin D1, and upregulated Bax and Cleaved-casp-3 in NPC cells after radiotherapy. Besides, miR-515-5p interacted with PVT1 and targeted PIK3CA in NPC cells. Further studies indicated that PVT1 regulated radioresistance via miR-515-5p/ PIK3CA axis and modulated the AKT pathway by interacting with miR-515-5p. Moreover, knockdown of PVT1 suppressed tumor growth in vivo. Conclusion: Downregulation of PVT1 inhibited proliferation, radioresistance and promoted apoptosis by downregulating PIK3CA via sponging miR-515-5p in NPC cells.