Miracle-dz/UniFAR-FTUs huggingface dataset:
ERYTHROCYTE OXIDATIVE STATUS AFTER MAXIMAL AEROBIC TEST IN WRESTLERS

2019. Т. 19, No 1. С. 15–21 15 Introduction. Physical exercise leads to changes in the oxidative status of the organism. In humans, the parameters of oxidative status are most commonly studied in the blood plasma and erythrocytes. The main function of erythrocytes is to supply cells with oxygen in order to maintain the aerobic metabolism. In this role, they are in constant contact with oxygen and are exposed to reactive oxygen species (ROS) impact. The main source of ROS in red blood cells is the autooxidation of oxyhemoglobin to methemoglobin [14, 18, 20]. During the auto-oxidation of methemoglobin, superoxide anion radicals (O2) are produced with a subsequent formation of hydrogen peroxide. The reduction of oxygen to superoxide and nitrite to nitrous oxide starts the cascades of oxidation reactions that induce oxidative stress (OS) in erythrocytes and lead to their damage [14]. All biomolecules – lipids, proteins and nucleic acids – can be a target of free radicals. The most commonly used marker for OS is the membrane lipid peroxidation (LPO), as phospholipids are the most susceptible to the action of ROS by the presence of polyunsaturated fatty acids in their structure. The erythrocytes can be attacked by ROS, generated in the blood plasma, such as hydrogen peroxide and nitric oxide. The red blood cells (RBC) are broadly investigated as a source of ROS, as well as a target for their action. To a large extent, this is determined by the wide variety of factors that can lead to hemolysis and cause hemolytic anemia [20]. It is known that the rate of auto-oxidation increases with a decrease in pH and PO2 (that is often observed during physical exercises) [2, 4, 14]. To deal with the ROS and to prevent their damaging effect, RBC are equipped with a wellorganized defense system. In humans, the activity of antioxidant enzymes in the RBC is higher than in most other tissues in the body [17]. In addition to the enzymes, nonenzyme antioxidants, such as tocopherols, ascorbate, urate and glutathione, also act upon the RBC. The purpose of this study was to determine the changes in oxidative status of erythrocytes in wrestlers, after performing the maximal aerobic test to exhaustion, by measuring the total glutathione (tGSH), the levels of thiobarbituric acid reactive substances (TBARS) as a marker of lipid DOI: 10.14529/hsm190102
Flow of Cells in Microchannels

This article investigates the motion of a cell in a carrier fluid flowing along a twodimensional channel. The cell, assumed elliptical, is modeled as a highly viscous fluid with rigid body motion. A fixed grid approach is used. A combined formulation with one set of governing equations to treat both phases is employed. The cell-fluid interface is tracked by a distance function. The finite volume method is employed to solve the governing equations. For demonstration purpose, the result for the flow of a single elliptical cell in an obstructed channel is presented.
Microfluidic Platform for Investigating Osteocyte Mechanoregulation of Breast Cancer Bone Metastasis

Bone metastasis is a severe complication that occurs in approximately 85% of patients with advanced breast cancer. Although the potential of exercise in attenuating metastatic tumor growth in bone had been shown in vivo, the role of mechanical loading on bone in preventing bone metastasis remains unknown. Osteocytes, as the major mechanosensory bone cells, are identified regulators in mediating loading inhibited bone metastasis in vitro. However, there is no ideal platform currently available for investigating the impact and mechanism underlying loading reduced bone metastasis. To bridge the gap between in vivo and in vitro experiments, this thesis develops a novel microfluidic cancer extravasation platform that integrates bone mechanical loading and real-time bi-directional signaling between multiple cell populations within the bone metastasis environment. Using our microfluidic extravasation platform, we observed the overall effect that mechanically-stimulated osteocytes regulate breast cancer transendothelial extravasation indeed, and the specific impact is breast cancer type dependent.
T HE T ECHNOLOGY OF P ROFESSIONAL T EACHING T HE S IMULATIVE C OMPANY AS A C OMPLEX OF I MITATIVE T EACHING M ETHODS

The characteristics of the competitive specialist and requirements for their training served the basis for the development of the generalized specialist model. A new imitative tutorial The Simulative Company, which is a systemized complex of operation teaching methods, is worked out and implemented. The research provides the algorithm of the teaching method The Simulative Company development realized and implemented by the authors in student groups on the specialties Management and Economy and Bookkeeping. The algorithm comprises the following stages: the launch of The Simulative Company (presenting The Simulative Company, the analysis of the environment); the functioning of The Simulative Company (recruitment, professional activity appraisals, partnering); the creation of an automated workplace. It is proved that in secondary professional educational institutions, active teaching methods should be given precedence to, which will increase the student's learning activity, facilitate the development of their initiative and personal potential, generate their creative approach, as well as will allow solving important teaching and organizational tasks. The established specifics of imitative teaching methods usage enable: to put into practice the models of the competitive specialist within the educational process; to realize the teacher’s potential in improving his/her pedagogical excellence; to implement the system of new imitative teaching methods which is presented by the new technology The Simulative Company.
Journal Homepage:-www

Sameera A. Alghamdi. Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia. Manuscript Info Abstract . Manuscript History Received: 12 August 2019 Final Accepted: 14 September 2019 Published: October 2019
ZmWAK-RLK1 correlates with reduced benzoxazinoid

Wall‐associated kinases (WAKs) have recently been identified as major components of fungal and bacterial disease resistance in several cereal crop species. However, the molecular mechanisms of WAK‐mediated resistance remain largely unknown. Here, we investigated the function of the maize gene ZmWAK‐RLK1 (Htn1) that confers quantitative resistance to northern corn leaf blight (NCLB) caused by the hemibiotrophic fungal pathogen Exserohilum turcicum. ZmWAK‐RLK1 was found to localize to the plasma membrane and its presence resulted in a modification of the infection process by reducing pathogen penetration into host tissues. A large‐scale transcriptome analysis of near‐isogenic lines (NILs) differing for ZmWAK‐RLK1 revealed that several differentially expressed genes are involved in the biosynthesis of the secondary metabolites benzoxazinoids (BXs). The contents of several BXs including DIM2BOA‐Glc were significantly lower when ZmWAK‐RLK1 is present. DIM2BOA‐Glc concentration was significantly elevated in ZmWAK‐RLK1 mutants with compromised NCLB resistance. Maize mutants that were affected in overall BXs biosynthesis or content of DIM2BOA‐Glc showed increased NCLB resistance. We conclude that Htn1‐mediated NCLB resistance is associated with a reduction of BX secondary metabolites. These findings suggest a link between WAK‐mediated quantitative disease resistance and changes in biochemical fluxes starting with indole‐3‐glycerol phosphate. DOI: https://doi.org/10.1111/nph.15419 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-184041 Journal Article Accepted Version Originally published at: Yang, Ping; Praz, Coraline; Li, Beibei; Singla, Jyoti; Robert, Christelle A M; Kessel, Bettina; Scheuermann, Daniela; Lüthi, Linda; Ouzunova, Milena; Erb, Matthias; Krattinger, Simon G; Keller, Beat (2018). Fungal resistance mediated by maize wall‐associated kinase Zm WAK‐RLK1 correlates with reduced benzoxazinoid content. New Phytologist, 221(2):976-987. DOI: https://doi.org/10.1111/nph.15419
Pengaruh Manajemen Laba Riil Terhadap Audit Fee

— This study aims to assess the impact of Real Earning Management (REM) towards the audit fee within manufacturer companies. Independent variable employed in the thesis is the REM while the audit fee is the dependent variable. The researchi methodi used isi descriptivei verificative methodology with qualitative research approach. This thesis usedi secondary data consisted of 90 acquired from analyzing 30 manufacturer companies that are registered ini Indonesiai Stock Exchangei within 3 years fromi 2016 to 2018. The result of thisi researchi showed that REM gives positive impact toward the audit fee of a manufacturer company therefore indication that the use of REM wouldi increasei a company’s audit fee. Suggestion for further research is using Audit Delay as dependent variable or as moderating varable influentiali to impact of Real Earningi Management (REM) towards the Audit fee. Abstract—
Towards More Open-Minded Nuclear Engineering Diversity, Independence and Public Good

© The Author(s) 2015 J. Ahn et al. (eds.), Reflections on the Fukushima Daiichi Nuclear Accident, DOI 10.1007/978-3-319-12090-4_22 Abstract The implication of the PAGES project especially in Japan’s postFukushima context is examined in this chapter, summing up the arguments of sister chapters in Part IV at the same time. Social scientific literacy is not just an “additional” component for nuclear engineers. Rather, it is one of the most “essential” parts of engineering competences and practices. This point has not been fully recognized, at least in the Japanese context so far. In this chapter, an epochmaking judgment by a Japanese court and the responses from nuclear engineers in Japan will be taken as a case to explore this issue. Japanese nuclear engineers misunderstood the judgment’s argument and could not make appropriate counterarguments against the court. This kind of misunderstanding of voices from society can result both in loss of political legitimacy and stagnation in technical evolution. Looking at the original nature of engineering itself, the need for fundamental change to re-establish diversity and independence in nuclear engineering, and the significance of social-scientific literacy to realize it, will be discussed.
Multiple-Strain Infections of Human Cytomegalovirus with High Genomic Diversity are Common In 3 Breast Milk from HIV-Positive Women in Zambia 4 5

Major article 1 2 Multiple-Strain Infections of Human Cytomegalovirus with High Genomic Diversity are Common In 3 Breast Milk from HIV-Positive Women in Zambia 4 5 Nicolás M. Suárez 1a , Kunda G. Musonda 2,3a , Eric Escriva 2,4 , Margaret Njenga 2b , Anthony Agbueze 2,4 , 6 Salvatore Camiolo 1 , Andrew J. Davison 1 , and Ursula A. Gompels 2b 7 8 MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom; Pathogen 9 Molecular Biology Department, London School of Hygiene and Tropical Medicine, London, United 10 Kingdom; Virology Laboratory, University Teaching Hospital, Lusaka, Zambia; Birkbeck College, 11 University of London, London, United Kingdom 12 13 Running title: HCMV diversity in milk 14 15 Abstract: 200 words 16 Main text: 3500 words 17 18 A preprint version of this paper was published in December 2018 (BioRxiv 493742. doi: 19 https://doi.org/10.1101/493742). 20 N. M. S. and K. G. M. contributed equally to this study. 21
Some remarks on the optional decomposition theorem

© Springer-Verlag, Berlin Heidelberg New York, 1998, tous droits réservés. L’accès aux archives du séminaire de probabilités (Strasbourg) (http://portail. mathdoc.fr/SemProba/) implique l’accord avec les conditions générales d’utilisation (http://www.numdam.org/legal.php). Toute utilisation commerciale ou impression systématique est constitutive d’une infraction pénale. Toute copie ou impression de ce fichier doit contenir la présente mention de copyright.
Semi-Lorentz invariance, unitarity, and critical exponents of symplectic fermion models

We study a model of N-component complex fermions with a kinetic term that is second order in derivatives. This symplectic fermion model has an Sp(2N) symmetry, which for any N contains an SO(3) subgroup that can be identified with rotational spin of spin-½ particles. Since the spin-½ representation is not promoted to a representation of the Lorentz group, the model is not fully Lorentz invariant, although it has a relativistic dispersion relation. The hamiltonian is pseudo-hermitian, H† = CHC, which implies it has a unitary time evolution. Renormalization-group analysis shows the model has a low-energy fixed point that is a fermionic version of the Wilson-Fisher fixed points. The critical exponents are computed to two-loop order. Possible applications to condensed matter physics in 3 space-time dimensions are discussed.
Wiuelogłos Special Issue-First View

The term “multilingualism” or “multilingualism of literature” is most commonly associated with authors writing in two or more languages either in various literary genres or in diff erent phases of their artistic activity or life. With regard to Polish literature, we may easily enlist the most renown ones: Stanisław Przybyszewski, Tadeusz Rittner, later also Stefan Themerson, Gustaw Heling-Grudziński, and at the beginning of the 21st century Sokrat Janowicz, Ewa Kuryluk, and Dariusz Muszer. The change of a language is often caused by (forced or voluntary) emigration, which is the most frequently noted circumstance, but also by the multicultural space, in which such authors grow into by their biographies. This is the case of e.g. Tadeusz Rittner and Sokrat Janowicz. While the decision to change the language (or to expand the variety of languages) is always individual, it is supported by the ubiquity of migratory fl ows and the so-called social multilingualism [Gesellschaftliche Mehrsprachigkeit, see: Kremnitz 1990]. Social multilingualism, that is multilingualism characterising not individuals but entire groups or social stratums, concerns, on the one hand, historical multicultural superpowers (like Austria-Hungary and Galicia located in it) or the today’s multilingual countries (Canada or WIELOGŁOS Pismo Wydziału Polonistyki UJ 2018; Special Issue (english version), s. 91– doi: 10.4467/2084395XWI.18. 014.9882 www.ejournals. eu/Wieloglos
Ultrasound contrast agents modeling using an extended Volterra model

Harmonic imaging has historically occurred with the introduction of ultrasound contrast agents such as microbubbles. These agents, due to their nonlinear behavior, have provided a great increase in the contrast of ultrasound images. Although this modality has revolutionized the clinical practice, it still suffers from the presence of harmonics in the echo of the tissue that reduce its efficiency. One way to overcome this problem was to turn to the sub-harmonic imaging based on the reception of sub-harmonics generated by microbubbles at high pressure levels. Modeling of the signals backscattered by microbubbles was performed with nonlinear models such as Volterra series. These models have exhibited high efficiency in modeling harmonics. However, they are inadequate to model sub- and ultra-harmonics. In this paper, we propose an extension of the Volterra series in order to model these sub- and ultra-harmonics. Results showed that signals backscattered by the medium infused with microbubbles can be accurately represented by the derived model. The gain achieved with our method was 2.3 dB compared to the standard Volterra modeling. In the frequency domain, the spectrum of the simulated signal has described perfectly that of the microbubble.
Real Options Analysis in Appraisal of Commercial Property Developments

Purpose: The objective of this paper is to demonstrate the application of real options analysis (ROA) to real estate development (RED) appraisal with the aim of enhancing real estate investment decision making. Design/methods: Using data of three commercial RED as case studies, the study compared the results of the appraisal output of the traditional DCF(NPV) under three scenarios of most optimistic, most likely and most pessimistic, against the results obtained from the ROA using the Samuelson McKean formula. The study examined the options to delay development and vertically expand development. Findings: The results showed that the use of the traditional appraisal models favours a stable and optimistic market; with positive trends and forecast. Thus, during unanticipated market downturns, investors might be exposed to the greater level of downside risk when RED investments are appraised based on the traditional models only. This implies the needs to encourage the adoption of a more flexible appraisal technique such as the ROA. Practical Implication: The paper gives a further insight on the use of ROA in comparison with appraisal the traditional appraisal models. Originality: From the perspective of an emergent market, this paper is one of the few attempts that seeks to demonstrate the practical application of ROA in practice.
Assessment of Transversus Abdominis Plane Block in Abdominal Surgery by Total Requirement of Diclofenac as a Post-Operative Analgesia Drug

Jigna R Shah, Apoorva Moghe, Maulik Humbal Associate Professor, Department of Anaesthesia, GMERS Medical College, Sola Civil Hospital, Sola, Ahmedabad, Gujarat, India, Second Year Resident, Department of Anaesthesia, GMERS Medical College, Sola Civil Hospital, Sola, Ahmedabad, Gujarat, India, First Year Resident, Department of Anaesthesia, GMERS Medical College, Sola Civil Hospital, Sola, Ahmedabad, Gujarat, India.
Linguistics Vanguard

In recent studies in second language (L2) development, notably within the focus of Complex Dynamic Systems Theory (CDST), non-systematic variation has been extensively studied as intra-individual variation, which we will refer to as variability. This paper argues that variability is functional and is needed for development. With examples of four longitudinal case studies we hope to show that variability over time provides valuable information about the process of development. Phases of increased variability in linguistic constructions are often a sign that the learner is trying out different constructions, and as such variability can be evidence for change, and change can be learning. Also, a limited degree of variability is inherent in automatic or controlled processes. Conversely, the absence of variability is likely to show that no learning is going on or the system is frozen.
Roles of miR-592-3p and Its Target Gene, TMEFF1, in the Nucleus Accumbens During Incubation of Morphine Craving

Abstract Background Prolonged forced abstinence from morphine can increase cue-induced cravings for the drug, contributing to a persistent vulnerability to relapse. Previous studies have identified the implications of aberrant microRNA (miRNA) regulation in the pathogenesis of morphine addiction, but the changes in miRNA expression during the incubation of morphine craving are still unknown. Methods Nucleus accumbens (NAc)-specific altered miRNA transcriptomics was determined in a mouse model of cue-induced incubation of morphine craving following a next-generation sequencing method and verified by RT-qPCR. Bioinformatics analysis was performed to predict the target gene of selected miRNA, and the protein expression of the target gene was detected by western blot. A dual-luciferase assay was performed to confirm the binding sites, and gain- and loss-of-function strategy was applied to understand the mechanism of miRNA and its target gene. Results The miR-592-3p observed to be downregulated in the NAc core was linked to the incubation of morphine craving, and a dual-luciferase assay was performed to confirm the binding sites of miR-592-3p in its target gene, tomoregulin-1 (TMEFF1). Also, gain- and loss-of-function analyses revealed that the inhibition of miR-592-3p expression in the NAc core negatively regulated TMEFF1 expression, thereby enhancing the incubation of morphine craving; however, the overexpression of miR-592-3p in the NAc core resulted in a decreased expression of TMEFF1, thereby reducing the incubation of morphine craving. Conclusion Our findings demonstrated that miR-592-3p can improve the incubation of morphine craving by targeting TMEFF1, and thus, it holds a therapeutic potential to inhibit opioid craving.
Delayed brain metastasis after 17-years from papillary thyroid cancer without local recurrence: case report and literature review

Abstract Papillary thyroid carcinoma (PTC) is the most common malignancy originating from the thyroid, with a good overall prognosis. However, distant metastasis of such lesions is very rare, with the brain being an incredibly uncommon site for secondary spread. The authors report a case of PTC brain metastasis 17-years after successful treatment of the primary malignancy, with no local or locoregional recurrence. Initial diagnostic uncertainty necessitated the involvement of a multidisciplinary team, and eventually the patient underwent image-guided gross surgical resection with intraoperative neuromonitoring (IOMN).
Outcomes and predictors of skin sodium concentration in dialysis patients

ABSTRACT Background Sodium-23 magnetic resonance imaging (23Na MRI) allows the measurement of skin sodium concentration ([Na+]). In patients requiring dialysis, no data are available relating to the clinical outcomes associated with skin sodium accumulation or the determinants of increasing deposition. Methods This was an exploratory, observational study of adult hemodialysis (HD) and peritoneal dialysis (PD) patients. Participants underwent skin [Na+] quantification with leg 23Na MRI at the study’s beginning. Outcomes of interest were all-cause mortality and composite all-cause mortality plus major adverse cardiovascular events. Cumulative total and event-free survival were assessed using the Kaplan–Meier survival function after stratification into skin [Na+] quartiles. Cox proportional hazards regression was used to model the association between skin [Na+] and outcomes of interest. Multiple linear regression was used to model the predictors of skin [Na+]. Results A total of 52 participants (42 HD and 10 PD) underwent the study procedures. The median follow-up was 529 days (interquartile range: 353–602). Increasing skin [Na+] quartiles were associated with significantly shorter overall and event-free survival (log-rank χ2(1) = 3.926, log-rank χ2(1) = 5.685; P for trend <0.05 in both instances). Skin [Na+] was associated with all-cause mortality {hazard ratio (HR) 4.013, [95% confidence interval (95% CI) 1.988–8.101]; P < 0.001} and composite events [HR 2.332 (95% CI 1.378–3.945); P < 0.01], independently of age, sex, serum [Na+] and albumin. In multiple regression models, dialysate [Na+], serum albumin and congestive heart failure were significantly associated with skin [Na+] in HD patients (R2adj = 0.62). Conclusions Higher skin [Na+] was associated with worse clinical outcomes in dialysis patients and may represent a direct therapeutic target.