Miracle-dz/UniFAR-FTUs huggingface dataset:
An Assessment of Serum Selenium Concentration in Women with Endometrial Cancer

Background: Numerous studies have shown a relationship between low serum selenium levels and an increased risk of developing cancer. Methods: A total of 306 women participated in the study: 153 patients diagnosed with endometrial cancer and 153 healthy women who were matched, in terms of birth year (+/−3 years), to the patients from the study group. The quantitative measurement of selenium content in the collected blood samples was performed using a mass spectrometer with excitation in inductively coupled plasma. In order to determine the relationship between the risk factors and the incidence of endometrial cancer, analyses based on single- and multi-factor conditional logistic regression models were performed. Results: The mean concentration of selenium was lower in patients with endometrial cancer than in healthy controls (60.63 µg/L (0.77 µmol/L) vs. 78.74 µg/L (0.99 µmol/L), respectively). When compared in quartiles, a significant association of lower selenium concentration with the incidence of endometrial cancer was recorded. The highest OR was observed in the first and second quartiles (OR-22.0, p-value < 0.001; medium selenium level 46.95 µg/L (0.59 µmol/L), and OR-5.94; p-value < 0.001; medium selenium level 63.60 µg/L (0.80 µmol/L), respectively). Conclusion: A strong correlation between the level of selenium in the blood serum and the risk of endometrial cancer indicates that patients with low levels should be a candidate group requiring appropriate preventive examinations. Further research on a larger group of patients is required.
EEG Evoked Potentials to Repetitive Transcranial Magnetic Stimulation in Normal Volunteers: Inhibitory TMS EEG Evoked Potentials

The impact of repetitive magnetic stimulation (rTMS) on cortex varies with stimulation parameters, so it would be useful to develop a biomarker to rapidly judge effects on cortical activity, including regions other than motor cortex. This study evaluated rTMS-evoked EEG potentials (TEP) after 1 Hz of motor cortex stimulation. New features are controls for baseline amplitude and comparison to control groups of sham stimulation. We delivered 200 test pulses at 0.20 Hz before and after 1500 treatment pulses at 1 Hz. Sequences comprised AAA = active stimulation with the same coil for test–treat–test phases (n = 22); PPP = realistic placebo coil stimulation for all three phases (n = 10); and APA = active coil stimulation for tests and placebo coil stimulation for treatment (n = 15). Signal processing displayed the evoked EEG waveforms, and peaks were measured by software. ANCOVA was used to measure differences in TEP peak amplitudes in post-rTMS trials while controlling for pre-rTMS TEP peak amplitude. Post hoc analysis showed reduced P60 amplitude in the active (AAA) rTMS group versus the placebo (APA) group. The N100 peak showed a treatment effect compared to the placebo groups, but no pairwise post hoc differences. N40 showed a trend toward increase. Changes were seen in widespread EEG leads, mostly ipsilaterally. TMS-evoked EEG potentials showed reduction of the P60 peak and increase of the N100 peak, both possibly reflecting increased slow inhibition after 1 Hz of rTMS. TMS-EEG may be a useful biomarker to assay brain excitability at a seizure focus and elsewhere, but individual responses are highly variable, and the difficulty of distinguishing merged peaks complicates interpretation.
Study on Vision based On-machine Micro Tool Measurement Method

In order to inspect the condition of micro tools automatically and accurately in the micro milling process, a vision based on-machine measurement method is studied in this paper. The proposed methods can measure tool dimension, spindle radial runout and acquire the microscopic image with full depth of focus from both radial and axial direction. Based on the proposed method, a dedicated micro tool measuring system was established, which consists of on-machine measurement unit, control box and software. The measurement experiments on machine tool verified that the proposed methods and the developed measurement system can fulfill the needs of industrial applications.
Power Quality Improvement in Three-phase Telecommunication Power Supply System

Abstract This article proposes power quality improvement in a three-phase AC mains-fed telecommunication power supply by using an improved power quality converter. Conventional telecommunication tower power supplies suffer from power quality problems, such as high input current harmonic distortion, low power factor, and voltage distortions at the utility interface. To mitigate these problems, modern AC-DC converters with power factor correction circuits are used at the utility interface. An integrated boost converter is used as a power factor corrector with an isolated DC-DC converter at the load end to form the proposed telecommunication power supply. The power factor correction converter mitigates the harmonic contents of the AC mains current and improves the power factor, whereas the isolated converter provides regulated load voltage and isolation. Voltage control is used for regulating the DC voltage of the isolated converter, while the power factor correction integrated boost converter employs a current control loop to shape input current to sinusoidal in-phase with voltage. The design, modeling, and simulation results are presented to demonstrate the effectiveness of the power supply at various AC mains voltages and loads. A prototype of the front-end converter is developed, and recorded test results are presented here to validate the simulated performance.
Neonatal Outcome and Treatment Perspectives of Preterm Infants at the Border of Viability

Decision-making at the border of viability remains challenging for the expectant parents and the medical team. The preterm infant is dependent on others making the decision that will impact them for a lifetime in hopefully their best interest. Besides survival and survival without neurodevelopmental impairment, other relevant outcome measures, such as the quality of life of former preterm infants and the impact on family life, need to be integrated into prenatal counselling. Recommendations and national guidelines continue to rely on arbitrarily set gestational age limits at which treatment is not recommended, can be considered and it is recommended. These guidelines neglect other individual prognostic outcome factors like antenatal steroids, birth weight and gender. Besides individual factors, centre-specific factors like perinatal treatment intensity and the attitude of healthcare professionals significantly determine the futures of these infants at the border of viability. A more comprehensive approach regarding treatment recommendations and relevant outcome measures is necessary.
It is not just the category: behavioral effects of fMRI-guided electrical microstimulation result from a complex interplay of factors

Abstract Functional imaging and electrophysiological studies in primates revealed the existence of patches selective for visual categories in the inferior temporal cortex. Understanding the contribution of these patches to perception requires causal techniques that assess the effect of neural activity manipulations on perception. We used electrical microstimulation (EM) to determine the role of body patch activity in visual categorization in macaques. We tested the hypothesis that EM in a body patch would affect the categorization of bodies versus objects but not of other visual categories. We employed low-current EM of an anterior body patch (ASB) in the superior temporal sulcus, which was defined by functional magnetic resonance imaging and verified with electrophysiological recordings in each session. EM of ASB affected body categorization, but the EM effects were more complex than the expected increase of body-related choices: EM affected the categorization of both body and inanimate images and showed interaction with the choice target location, but its effect was location-specific (tested in 1 subject) on a millimeter scale. Our findings suggest that the behavioral effects of EM in a category-selective patch are not merely a manifestation of the category selectivity of the underlying neuronal population but reflect a complex interplay of multiple factors.
Congenital syphilis re-emergence in Winnipeg, Manitoba.

Background Infectious syphilis rates have been increasing in Winnipeg, Manitoba among individuals during their childbearing years. Untreated or inadequately treated prenatal infection often results in congenital syphilis, with devastating consequences to fetal health and survival. The objective of this study was to review public health surveillance data regarding congenital syphilis incidence and birthing parent risk factors in Winnipeg from 2018 to 2020. Methods Data extracted from a population-based surveillance database maintained by the Winnipeg Regional Health Authority Public Health investigations for all 2018-2020 probable or confirmed cases of early congenital syphilis or syphilitic stillbirth were reviewed. Rates of congenital syphilis were calculated per 1,000 live births. Descriptive analyses were performed to describe birthing parent age, neighbourhood of residence, intravenous substance use, Child and Family Services involvement, access to prenatal care and obtainment of adequate prenatal treatment. Results There were eight cases of confirmed/probable congenital syphilis in 2018, 22 cases in 2019 and 30 cases in 2020. Average birthing parent age was 26.5-27.0 years. The majority (66.7%) of birthing parents lived in inner city neighbourhoods with known infectious syphilis outbreaks. Over 50% of birthing parents did not receive any prenatal care, or the care received consisted of inadequate treatment or follow-up. Reinfection among birthing parents who did receive prenatal care was suspected in an additional 23.3% of cases. Conclusion Congenital syphilis rates in Winnipeg have increased dramatically. Public health and healthcare provider efforts to address the needs of the community are vital for promoting access to safe and effective prenatal care.
Aseptic Meningitis after Amenamevir Treatment for Herpes Zoster in the First Branch of the Trigeminal Nerve

Amenamevir has been approved for the treatment of herpes zoster (HZ); however, its therapeutic efficacy against central nervous system (CNS) infection may be insufficient due to its low spinal fluid permeability. We herein report a case of aseptic meningitis in a 91-year-old Japanese man treated with amenamevir for HZ in the trigeminal nerve region. Several cases of CNS infection have been reported in patients receiving amenamevir treatment for HZ. Patients with CNS complications often have skin rashes near the trigeminal region. Thus, we should be alert for signs of CNS infection when administering amenamevir to patients with such rashes.
Başarısız Bankart cerrahisine yaklaşım: Cerrahi teknikler ve klinik sonuçları

Omuz instabilitesinin cerrahisi sonrası gelişebilecek ana komplikasyon, tekrarlayan instabilitedir. Revizyon instabilite cerrahisi genellikle zordur. Cerrahi sonrası tekrarlayan omuz instabilitesi olan hastalar; sadece başarısızlığı teşhis etmek için değil, aynı zamanda sonucu belirleyen altta yatan nedenleri de açıkça belirlemek ve başarılı bir tedavi stratejisi oluşturmak için detaylı olarak değerlendirilmelidir. En iyi tedavinin planlanabilmesi için dikkatli bir ameliyat öncesi değerlendirme oldukça önemlidir. İnstabilitenin nedeni, atakların sayısı ve sıklığı, tekrarlama için gerekli travma şiddeti, ilk yaralanma anındaki kol pozisyonu ve semptomları tetikleyen kol pozisyonu hakkında detaylı bilgi edinilmelidir. [1]
INFLUENCE FEATURES OF OFFICE BUILDING RENTAL: A SYSTEMATIC LITERATURE REVIEW

In reviewing rental trends, investors are unable to rely on market data from real estate transactions due to inaccurate property rental valuations by valuers. Hence the objective of this research which is to identify the influencing features of office building rentals. This study performs a systematic review on the influencing features of office building rentals based on the PRISMA systematic review and meta-analysis. The results obtained indicate that office rent determinants such as green labels, vacancy levels, and location-specifics, have significant impact on office rents. This paper provides new insights for investors and valuers in determining office rental values in the real estate market.
Overall Survival and Related Factors of Advanced-stage Epithelial Ovarian Cancer Patients Underwent Debulking Surgery in Jakarta, Indonesia: A Single-center Experience

AIM: The worrisome prognosis of advanced-stage epithelial ovarian cancer (EOC) needs a new perspective from developing countries. Thus, we attempted to study the 5-year overall survival (OS) of advanced-stage EOC patients who underwent debulking surgery in an Indonesian tertiary hospital. METHODS: A retrospective study recruited forty-eight subjects between 2013 and 2015. We conducted multiple logistic regression analyses to predict risk factors leading to unwanted disease outcomes. The OS was evaluated through the Kaplan–Meier curve and Log-rank test. Cox proportional hazards regression examined prognostic factors of patients. RESULTS: Prominent characteristics of our patients were middle age (mean: 51.9 ± 8.9 years), obese, with normal menarche onset, multiparous, not using contraception, premenopausal, with serous EOC, and FIGO stage IIIC. The subjects mainly underwent primary debulking surgery (66.8%), with 47.9% of all individuals acquiring optimal results, 77.1% of patients treated had the residual disease (RD), and 52.1% got adjuvant chemotherapy. The risk factor for serous EOC was menopause (odds ratio [OR] = 4.82). The predictors of suboptimal surgery were serous EOC (OR = 8.25) and FIGO stage IV (OR = 11.13). The different OS and median survival were observed exclusively in RD, making it an independent prognostic factor (hazard ratio = 3.50). 5-year A five year OS and median survival for patients with advanced-stage EOC who underwent debulking surgery was 37.5% and 32 months, respectively. Optimal versus suboptimal debulking surgery yielded OS 43.5% versus 32% and median survival of 39 versus 29 months. Both optimal and suboptimal debulking surgery followed with chemotherapy demonstrated an OS 40% lower than those not administered (46.2% and 20%, respectively). The highest 5-year OS was in serous EOC (50%). Meanwhile, the most extended median survival was with mucinous EOC (45 months). CONCLUSION: Chemotherapy following optimal and suboptimal debulking surgery has the best OS among approaches researched in this study. RD is a significant prognostic factor among advanced-stage EOC. Suboptimal surgery outcomes can be predicted by stage and histological subtype.
High-Resolution Magnetic Resonance Imaging (HR-MRI) Evaluation of the Distribution and Characteristics of Intra-Aneurysm Thrombosis to Improve Clinical Diagnosis of Thrombotic Intracranial Aneurysm

Background We aimed to analyze the related factors of intracranial anterior circulation saccular artery thrombosis and its characteristics on high-resolution magnetic resonance imaging (HR-MRI) images to provide a basis for neurosurgeons to select the precise treatment strategy for thrombotic intracranial aneurysms (TIA). Material/Methods This retrospective analysis included 136 patients with unruptured intracranial anterior circulation artery aneurysms who underwent HR-MRI. The 136 aneurysms were divided into thrombus (41) and non-thrombus (95) groups. Single factor analysis of morphological and clinical indicators were conducted to select meaningful indicators for logistic regression analysis; the optimal diagnostic threshold was calculated through ROC curve analysis. The location and signal characteristics of thrombi were analyzed to inform clinical treatment. Results Single factor analysis revealed significant differences in patient age, aneurysm size, aneurysm neck, aspect ratio, size ratio, and hyperlipidemia between the 2 groups (P<0.05). Multi-factor regression analysis demonstrated that aneurysm size (OR=2.180) and aspect ratio value (OR=7.495) were correlated with intracranial thrombosis. ROC curve analysis showed that for aneurysms larger than 8 mm, the sensitivity and specificity of TIA prediction were 83% and 93%, respectively. For aneurysms with aspect ratio values greater than 2.5, sensitivity and specificity of TIA predication were 75% and 95%, respectively. The proportion of aneurysm wall enhancement and clinical symptoms in the thrombus group was significantly higher than that in the non-thrombus group. Conclusions Intracranial unruptured aneurysms with the size larger than 8 mm or with aspect ratio values higher than 2.5 indicated the possible formation of thrombosis in the aneurysm.
High Temperature Characterization up to 450°C of MOSFETs and Basic Circuits Realized in a Silicon-on-Insulator (SOI) CMOS Technology

Standard bulk CMOS technology targets operating temperatures of not more than 175°C. Silicon-on-insulator technologies are commonly used up to 250°C. In this work, we evaluate the limit for electronic circuit function realized in thin film SOI technologies for even higher temperatures. At Fraunhofer IMS, a versatile 1.0 μm SOI-CMOS process based on 200 mm wafers is available. It features three layers of tungsten metallization with excellent reliability concerning electromigration, as well as voltage-independent capacitors, various resistors, and single-poly-EEPROMs. We present a study of the temperature dependence of MOSFETs and basic circuits produced in this process. The electrical characteristics of an NMOSFET transistor and a PMOSFET transistor are studied up to 450°C. In a second step, we investigate the functionality of a ring oscillator (representing a digital circuit) and a band gap reference as an example of a simple analog component. The frequency and the current consumption of the ring oscillat.
Wind tunnel testing of a smart rotor with induced-strain actuation of blade twist

This paper presents the experimental results of hover tests with a 1/8th dynamically-scaled (Froude scale) helicopter rotor model with embedded piezoceramic elements as actuators to suppress vibrations. A 6-ft diameter four-bladed bearingless rotor model was built with banks of specially-shaped piezoelectric actuators embedded at +/- 45 deg on the top and bottom surfaces to manipulate blade twist at harmonics of the rotational speed. The twist performance of rotors with single-layer and dual-layer actuator configurations was measured using accelerometers located at the blade tip. The change in oscillatory rotor lift due to piezoactuation was measured by a rotating balance. Experimental results show that linear twist distributions on the order of 0.3 deg, resulting in increases of up to 9 percent of the nominal rotor lift, are possible with existing piezoceramic technology. Although the twist amplitudes attained in this experiment were less than the target value (2 deg for complete vibration suppression), partial reduction of rotor vibrations can be achieved with the current smart rotors. (Author)
Open Educational Resources: the challenges of ‘usability’ and copyright clearance

Abstract This article reflects on the experiences of Keele University's participation in repurposing teaching materials for open access as part of the GEES consortium within the Higher Education Academy/ JISC Open Educational Resources (OER) pilot project. The team at Keele contributed over 100 separate OER, principally PowerPoint slide sets, reading lists and activity sheets across a number of climate change and sustainability-related themes. This paper explores some of the challenges that arose in the ‘repurposing’ of existing teaching materials for open access, including the issues of end-user usability and obtaining copyright clearance for image intensive resources. The paper concludes with advice for those interested in making existing or new resources suitable for open access.
Effect of Lexical-Semantic Cues during Real-Time Sentence Processing in Aphasia

Using a visual world eye-tracking paradigm, we investigated the real-time auditory sentence processing of neurologically unimpaired listeners and individuals with aphasia. We examined whether lexical-semantic cues provided as adjectives of a target noun modulate the encoding and retrieval dynamics of a noun phrase during the processing of complex, non-canonical sentences. We hypothesized that the real-time processing pattern of sentences containing a semantically biased lexical cue (e.g., the venomous snake) would be different than sentences containing unbiased adjectives (e.g., the voracious snake). More specifically, we predicted that the presence of a biased lexical cue would facilitate (1) lexical encoding (i.e., boosted lexical access) of the target noun, snake, and (2) on-time syntactic retrieval or dependency linking (i.e., increasing the probability of on-time lexical retrieval at post-verb gap site) for both groups. For unimpaired listeners, results revealed a difference in the time course of gaze trajectories to the target noun (snake) during lexical encoding and syntactic retrieval in the biased compared to the unbiased condition. In contrast, for the aphasia group, the presence of biased adjectives did not affect the time course of processing the target noun. Yet, at the post-verb gap site, the presence of a semantically biased adjective influenced syntactic re-activation. Our results extend the cue-based parsing model by offering new and valuable insights into the processes underlying sentence comprehension of individuals with aphasia.
Pulse transformers

Pulse transformers capable of transmitting substantially rectangular voltage pulses, with durations of less than one microsecond, were developed for radar applications during World War II. Their primary functions were to match the impedances of high-power microwave radio-frequency electron-tube generators to electronic pulse generators and coaxial transmission cables, and to provide polarity reversal and impedance matching functions within pulse generator circuitry. The principle contributor to the development of satisfactory pulse transformers was the development of cores of thin-gauge magnetic materials having 1 μs pulse permeabilities in the range of 500 to 3500 for flux-density changes of 10 000 G. The development of void free dry-type insulation systems made it possible to produce dry-type pulse transformers for operation at pulse voltages below 12 kV. The pulse transformer development work was paralleled by analytical work which enabled pulse transformer designers to make designs to meet the requirements of the radar circuit designers. The analysis relates the three principle pulse transformer parameters, which are magnetizing inductance, leakage inductance, and effective distributed capacitance, in combination with the circuit parameters which are source resistance, effective load resistance, and load shunt capacitance, to the rise time, top ripple and droop, and fall time of the output pulse. Pulse transformers now cover a wide range of sizes and power levels and pulse widths. Small units in computer applications may deliver only a few volts at pulse widths less than 0.1 μs. Large units in linear accelerators, however, may deliver pulse powers of 70 MW at 270 kV with a pulse width of about 3 μs.