Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunohistochemical study of the brain glutamine synthetase expression in the rat septic model

Severe sepsis is accompanied by multiple organ dysfunction where acute liver failure (ALF) plays one of the most critical roles. The principal sign of acute hepatic encephalopathy accompanying ALF is ammonia induced edema of astrocytes. In case of ALF in sepsis, one can suppose increase in systemic and brain ammonia. Astroglia are target cells for ammonia metabolism as they are principal source of glutamine-synthetase (GS). Previous studies have reported that ALF stimulates increase in astroglial GS which correlates with deterioration of the animal state. The aim of the study was to determine the level of glutamine synthetase expression in different brain regions of rats in the conditions of experimental sepsis. Materials and methods. The study was conducted in Wistar rats: 5 sham-operated (control) animals and 20 rats with cecum ligation and puncture (CLP) septic model. Immunohistochemical study of GS expression was performed in the cortex, white matter, hippocampus, thalamus, caudate nucleus/putamen in the period of 20–48 h after CLP. Results. Starting at 12th h after CLP, operated animals displayed progressive impairment finished by profound lethargy and respiratory failure. Between 20–38 h, 9 animals expressed final mentioned symptoms and were euthanized (CLP-B, non-survived), 11 rats displayed less expressed suffering up to 48 h (CLP-A, survived). At 23 h in CLP-B and 48 h in CLP-A rats, liver tissue displayed morphological signs of the focal irreversible damage which was aggravated with time after CLP which could be observed dynamically in non-survived group. Both CLP-A and CLP-B rats showed gradual elevation of GS in all studied brain regions. From 24 to 38 h after CLP, non-survived animals showed significant region-specific dynamic increase in GS expression: in the cortex – by 69.35 %, hippocampus – by 53.6 %, thalamus – by 50.0 %; with the most substantive elevation in the cortex – 1.69-fold increase compared to control. Conclusions. In CLP model, 24 h after operation there is significant dynamic increase in GS level in the cortical, hippocampal and thalamic regions of the rat brain with the most prominent in the cortex. Heterogeneous increase in GS indicates regions more or less vulnerable for incoming systemic agents as well as region-specific reactiveness of the brain tissue, including local astroglia, to these factors in septic conditions. Morphological signs of sepsis-associated liver damage preceding significant increase in the brain GS by 1 h, might suppose addition of the liver failure to the course of sepsis which is accompanied by increased level of hepatogenic toxins (presumably including ammonia) in the blood and in the brain parenchyma by 23 h after CLP. The latter might propose an active implication of hepatogenic detrimental agents in sepsis pathophysiology and involvement of reactively increased brain GS levels in the complex mechanisms of sepsis-associated encephalopathy.
Adipose-derived stem cells postpone the progression of Sjögren's syndrome by upregulating the Hippo signaling pathway

The aim of the present study was to explore the effect and mechanism of action of adipose-derived stem cells (ADSCs) on Sjögren syndrome (SS) to develop novel and more effective methods for SS treatment. ADSCs, dexamethasone or normal saline was injected into the submandibular gland (SMG) of three 12-week-old non-obese diabetic (NOD) mice. The degree of lymphocyte infiltration was considered as a criterion for judging disease progression, hematoxylin and eosin staining was performed to observe the pathological state, and the expression levels of TAZ, E-cadherin and α-catenin were assessed by western blotting. ADSC transplantation triggered an inhibitory effect on the progression of SS, which was slightly stronger compared with that of dexamethasone treatment. This was found to be related to the Hippo signaling pathway. In addition, TAZ protein expression levels decreased gradually with the progression of the disease; immunofluorescence staining showed that the expression of E-cadherin and TAZ followed similar trends. Notably, the expression of TAZ, p-TAZ, E-cadherin and α-catenin in NOD mice were lower compared with that in Control mice. Similarly, the ratio of p-TAZ/TAZ also decreased, which means that the activation level of Hippo signal pathway decreased. The results suggest that ADSCs may exert a therapeutic effect against SS and may postpone its progression by upregulating the Hippo signaling pathway.
T OWARDS N EW A NALYSIS A ND V ISUALIZATION S OFTWARE FOR S TUDYING P ERFORMANCE P ATTERNS IN H ARDANGER F IDDLE M USIC

Analyzing musical performances is a challenging and emergent ﬁeld of computational music research, aiming to reveal performance patterns and link them to musical contexts. There exists a modest amount of computational research on Hardanger ﬁddle performances. The MIRAGE research project is currently contributing to this scientiﬁc body, developing advanced MIR frameworks that build on recent musicological research. This paper presents the development and evaluation of two Max/MSP/Jitter software applications 1 2 for music analysis and data visualization that integrate contemporary research perspectives on the complex rhythmical structuring of springar performances, investigating how we can design user-friendly computational tools that explore performance patterns in Hardanger ﬁddle music, in collaboration with MIRAGE. Based on a small questionnaire and a few operational tests, the study shows an interest in more effective software tools capable of revealing complex interrelations between musical dimensions in Hardanger ﬁddle performances. Additionally, the study highlights design considerations for tools aiming to increase the availability of computational music research in the ﬁeld of musicology, such as cross-compatibility and integrated features that actively facilitate nuanced interpretation processes.
THE GAME OF LEARNING! APPROACHING ECOSYSTEMS THROUGH BOARD GAME DESIGN

Game-based learning is proven to be a motivational and effective approach, especially in STEM education. However, the process of developing a game is rarely used as an educational tool. Ecology is part of the science curriculum in Italian high schools, but for students results not easy to understand the ecosystem structures and functions from a systemic perspective. Furthermore, addressing ecological issues in a changing world will request them not a reductionist approach but a systems perspective. In this work our main objective is to consider further possibilities offered by board games, exploiting not only the game experience but also the use of the game design process as an immersive motivational learning tool for science, with a learning by doing approach. Ten students have been engaged (16-18) in two activities: events to test and analyse cooperative board games and a laboratory for the development of a new board game on ecosystems ("YouTopia – La Valle ecosistemica"). Two focus groups were conducted, before and at the end of the laboratory, to test students' engagement and to collect feedback about the efficacy of the method to boost interest and specific knowledge in ecology. The research reveals that game development can foster system thinking skills among students, and act as a powerful learning tool for complex subjects such as ecology. Results are encouraging and the proposed approach has the potential to be applied and replicated in high school and middle school, to foster students’ engagement in tackling and understanding topics such as evolution, genetics other topics characterized by complexity and systemic approach. Preliminary results show as the YouTopia game could be a valid tool for citizenship education. By playing the game, students investigate and practice democracy, the mechanisms of land planning and natural resources protection, and the principle of coresponsibility in making choices for the future.
VLA observations of low luminosity radio galaxies. VII - General properties

Un echantillon complet de 101 radiogalaxies de faible luminosite, pour lesquelles des cartes radio a haute resolution ont ete obtenues par observations VLA, est etudie. Les noyaux radio, les jets, radio, les lobes et les points chauds sont analyses. Une relation entre la luminosite totale et la luminosite du noyau est etablie
Decoding of Turning Intention during Walking Based on EEG Biomarkers

In the EEG literature, there is a lack of asynchronous intention models that realistically propose interfaces for applications that must operate in real time. In this work, a novel BMI approach to detect in real time the intention to turn is proposed. For this purpose, an offline, pseudo-online and online analysis is presented to validate the EEG as a biomarker for the intention to turn. This article presents a methodology for the creation of a BMI that could differentiate two classes: monotonous walk and intention to turn. A comparison of some of the most popular algorithms in the literature is conducted. To filter the signal, two relevant algorithms are used: H∞ filter and ASR. For processing and classification, the mean of the covariance matrices in the Riemannian space was calculated and then, with various classifiers of different types, the distance of the test samples to each class in the Riemannian space was estimated. This dispenses with power-based models and the necessary baseline correction, which is a problem in realistic scenarios. In the cross-validation for a generic selection (valid for any subject) and a personalized one, the results were, on average, 66.2% and 69.6% with the best filter H∞. For the pseudo-online, the custom configuration for each subject was an average of 40.2% TP and 9.3 FP/min; the best subject obtained 43.9% TP and 2.9 FP/min. In the final validation test, this subject obtained 2.5 FP/min and an accuracy rate of 71.43%, and the turn anticipation was 0.21 s on average.
Antiplatelet strategies

Antiplatelet therapy has now been shown to reduce the risk of serious vascular events by about one-quarter, not just among patients with acute coronary syndromes, stroke or TIA, but also among other categories of patients with coronary or peripheral arterial disease or those at high risk of embolism. Antiplatelet strategies based on permanent modifications of a platelet protein by a short-lived active moiety (e.g., aspirin or clopidogrel) are ideally suited to this effect. The available evidence supports daily doses of aspirin in the range 75–100 mg for the long-term prevention of serious vascular events in high-risk patients, as the best strategy to maximize both efficacy and safety. Other antiplatelet drugs can be substituted for or combined with aspirin in some conditions.
Comparative Topographical Description of the Central Nervous System of the Macaw (Ara ararauna) and the Owl (Tyto furcata)

Comparative topographical description of the central nervous system of the macaw ( Ara ararauna ) and the owl ( Tyto furcata ). SUMMARY: The study of animal neurology has historically focused on the closest descendants of humans, such as monkeys and chimpanzees. Because of this, the neurology of birds remains poorly studied and understood by humans compared to other groups of animals. Thus, the objective was to describe the central nervous system to better understand its functioning, correlating the findings with the role it plays in the physiology and biology of birds, comparing species with different behaviors between herbivores and carnivores, filling gaps in the literature serving as subsidy for future research.
Customer Knowledge Management in social media: application of the SMARTUR Framework for the proposition of smart solutions

This research demonstrates the application of the Smart Management of the Tourist Experience (SMARTUR) framework in the intelligent management of tourist experiences shared on TripAdvisor, so as to propose smart solutions in the city of Florianópolis (Brazil). The study also presents the main results obtained from applying the framework and its contribution to an intelligent management of tourist experiences and consequently the improvement of these experiences through the creation of smart solutions for this purpose. In addition, the application demonstrates the need to remodel the way Destination Management Organizations manage the tourist destination and how SMARTUR can contribute to this. More specifically, as it reveals how tourism managers can plan, collect, process, and analyze tourist experiences through their specific dimensions and thus identify strategic points in each of these dimensions that guide DMOs in proposing smart solutions which are more in line with tourist demands.
Assessing the Suitability of Habitats for Porphyrio porphyrio indicus and Amaurornis phoenicurus in Urban Wetlands of Peninsular Malaysia

It becomes imperative to understand the eco-climatic predictors and know the suitable habitat for Porphyrio porphyrio indicus and Amaurornis phoenicurus in the urban wetlands to prevent their local extinction. The study explored the habitat suitability for Porphyrio porphyrio indicus and Amaurornis phoenicurus in Paya Indah wetlands and Putrajaya wetlands of Peninsular Malaysia. Porphyrio porphyrio indicus and Amaurornis phoenicurus surveyed using the point count technique, and a stratified random design. The maximum entropy modelling (MEM) approach and geographic information systems employed to determine the influence of 17 eco-climatic factors on the suitable habitats for the species. Water at a minimum depth (44.30%) and rainfall (74.20%) contributed to the availability of suitable habitats for Porphyrio porphyrio indicus in Paya Indah and Putrajaya wetlands. Also, dissolved oxygen (56.60%) and salinity (43.50%) contributed to habitat suitability for Amaurornis phoenicurus in Paya Indah and Putrajaya wetlands. Large portions of the two urban wetlands were unsuitable for the Porphyrio porphyrio indicus and Amaurornis phoenicurus populations because of several eco-climatic factors. Thus, the models as management tools with a robust population monitoring database and framework would enhance the management effectiveness of the two species and urban wetlands.
Macro and micro wettability of hydrophobic siloxane films with hierarchical surface roughness

A method has been proposed to control the macro- and micro-wetting properties of hydrophobic surfaces through changes in the roughness due to modifying siloxane films with silica microparticles (MP). An experimental and theoretical analysis of macro- and micro-wettability dependence on the roughness of a film surface was carried out by combination of SEM and XPS methods with evaluation of equilibrium contact angles from Tadmor’s equation. SEM images (environmental mode) allowed characterizing the mosaic hydrophobicity/hydrophilicity of the siloxane film surface. Hydrophobic siloxane films filled with silica MP were synthesized on the plasma activated and non-activated glass substrates by the sol-gel dip-coating method using tetraethylorthosilicate based precursor compositions with subsequent reaction with hexamethyldisilazane. The values of water contact angles higher than 150° indicating a superhydrophobic effect were observed for films with combining nano- and micro-hierarchical roughness. Moreover, considering wettability on the micro scale the hybrid effect was discovered and confirmed by the SEM and XPS studies showing the presence of not only hydrophobic but also hydrophilic surface domains.
Literature Review of Mobility as a Service

The number of publications about mobility as a service (MaaS) has increased rapidly in the past years, spreading into various fields. In this paper, a total of 127 scientific publications about MaaS are reviewed and categorized into an overarching thematic framework in order to highlight key areas of research and further potential. Three research questions are highlighted in this review: (1) which topics are discussed in the existing MaaS literature? (2) what are the main results in the specific fields? and (3) where are gaps for further research? Publications have focused substantially on the topics of the market, users, data and technology, and the impact on the transportation system. The review shows that, regarding the concept, multi-level approaches have been established for the organization and cooperation of the actors involved, showing different levels of integration of public and private actors on a regional and supra-regional level. Various groups have already been identified as potential users, but the relatively low willingness to pay and the requirements regarding the individualization of mobility services pose problems that have not yet been solved. There is also a constant and unsolved challenge regarding the sensitive motion data that must be stored and processed. Significant research is still needed, including assessments of the impact of MaaS and what effects the service will have on the established use of transport modes, as well as how packages need to be designed and priced in order to optimally reach users.
Unsteady MHD on Convective Flow of a Newtonian Fluid Past an Inclined Plate in Presence of Chemical Reaction with Radiation Absorption and Dufour Effects

In this study, emission incorporation and Dufour belongings are investigated for uneven magnetohydrodynamic assorted convection stream over a disposed holey moving shield with thermal emission, heat assimilation, and homogenous substance reactions subjected to changeable suction. The governing momentum equation, as well as the energy and mass diffusion equations, have analytical solutions. The Nusselt number, the Sherwood number, in addition to velocity, temperature, attentiveness, and skin friction, are computed and examined analytically and visually in order to observe the manipulate of a variety of parameters. Grashof number (Gr), modified Grashof number (Gm), magnetic parameter (M), permeability parameter (K), Prandtl number (Pr), Heat Sink (Q), Radiation parameter (F), Dufour parameter (Du), Radiation absorption constraint (R), Schmidt number (Sc), and Chemical reaction parameter (K0) are all non-dimensional parameters with different values. In porous medium, slow-moving chemical reaction fluids are the only source of the issue. In the future, researchers may look at the inertia effects of porous medium for high-velocity flows. Researchers interested in radiation absorption effects in porous media will find this a highly helpful resource.
The Effect of the Gut Microbiota on Systemic and Anti-Tumor Immunity and Response to Systemic Therapy against Cancer

Simple Summary The gut microbiome affects the development of systemic immune response and it can also impact response to systemic treatments such as immunotherapy and chemotherapy. This article provides and in-depth overview of various mechanisms that the gut microbiome interacts with the immune system, cancer, and how it affects anti-tumor immunity and response to immunotherapy. Abstract Gut microbiota can have opposing functions from pro-tumorigenic to anti-tumorigenic effects. Increasing preclinical and clinical evidence suggests that the intestinal microbiota affects cancer patients’ response to immune checkpoint inhibitors (ICIs) immunotherapy, such as anti-programmed cell death protein 1 (PD-1) and its ligand (PD-L1) and anti-cytotoxic T lymphocyte-associated protein 4 (CTLA-4). Microbiota-induced inflammation possibly contributes to tumor growth and cancer development. Microbiota-derived metabolites can also be converted to carcinogenic agents related to genetic mutations and DNA damage in organs such as the colon. However, other attributes of microbiota, such as greater diversity and specific bacterial species and their metabolites, are linked to better clinical outcomes and potentially improved anti-tumor immunity. In addition, the intratumoral microbial composition strongly affects T-cell-mediated cytotoxicity and anti-tumor immune surveillance, adding more complexity to the cancer-microbiome-immune axis. Despite the emerging clinical evidence for the activity of the gut microbiota in immuno-oncology, the fundamental mechanisms of such activity are not well understood. This review provides an overview of underlying mechanisms by which the gut microbiota and its metabolites enhance or suppress anti-tumor immune responses. Understanding such mechanisms allows for better design of microbiome-specific treatment strategies to improve the clinical outcome in cancer patients undergoing systemic therapy.
Multi-Scale LBP Texture Feature Learning Network for Remote Sensing Interpretation of Land Desertification

Land desertification is a major challenge to global sustainable development. Therefore, the timely and accurate monitoring of the land desertification status can provide scientific decision support for desertification control. The existing automatic interpretation methods are affected by factors such as “same spectrum different matter”, “different spectrum same object”, staggered distribution of desertification areas, and wide ranges of ground objects. We propose an automatic interpretation method for the remote sensing of land desertification that incorporates multi-scale local binary pattern (MSLBP) and spectral features based on the above issues. First, a multi-scale convolutional LBP feature extraction network is designed to obtain the spatial texture features of remote sensing images and fuse them with spectral features to enhance the feature representation capability of the model. Then, considering the continuity of the distribution of the same kind of ground objects in local space, we designed an adaptive median filtering method to process the probability map of the extreme learning machine (ELM) classifier output to improve the classification accuracy. Four typical datasets were developed using GF-1 multispectral imagery with the Horqin Left Wing Rear Banner as the study area. Experimental results on four datasets show that the proposed method solves the problem of ill classification and omission in classifying the remote sensing images of desertification, effectively suppresses the effects of “homospectrum” and “heterospectrum”, and significantly improves the accuracy of the remote sensing interpretation of land desertification.
SEMINAR ON THROMBOLYSIS IN MYOCARDIAL INFARCTION-V

Pump failure, ranging from ventricular dysfunction to acute cardiogenic shock, is now the leading cause of cardiac death. Efforts at temporary mechanical or pharmacologic support of the heart have been largely unsuccessful so that attention is now directed toward prevention of ventricular failure and limitation of myocardial infarct size or even outright prevention of infarction itself. In particular, attention has been refocused on earlier reperfusion efforts with streptokinase. The effect of thrombolysis in acute myocardial infarction on enzymatic infarct size, left ventricular function and early mortality wasstudied in subsets of patients in a randomized trial (Netherlands Interuniversity Cardiology Institute). Early thrombolytic therapy with intracoronary streptokinase (152 patients) or with intracoronary streptokinase preceded by intravenous streptokinase (117 patients) was compared with conventional treatment (264 patients). All 533 patients were admitted to the coronary care unit within 4 hours after onset of symptoms indicative of acute myocardial infarction. Of the patients eligible for this detailed analysis, 245 were allocated to thrombolytic therapy and 243 to conventional treatment. Early angiography was performed in 212ofthe 245patients allocated to thrombolytic therapy.