Miracle-dz/UniFAR-FTUs huggingface dataset:
THE HADRONIC ORIGIN OF THE HARD GAMMA-RAY SPECTRUM FROM BLAZAR 1ES 1101-232

The very hard γ-ray spectrum from distant blazars challenges the traditional synchrotron self-Compton (SSC) model, which may indicate that there is a contribution from an additional high-energy component beyond the SSC emission. In this paper, we study the possible origin of the hard γ-ray spectrum from distant blazars. We develop a model to explain the hard γ-ray spectrum from blazar 1ES 1101-232. In the model, the optical and X-ray radiation would come from the synchrotron radiation of primary electrons and secondary pairs and the GeV emission would be produced by the SSC process, however, the hard γ-ray spectrum would originate from the decay of neutral pion produced through proton–photon interactions with the synchrotron radiation photons within the jet. Our model can explain the observed spectral energy distribution of 1ES 1101-232 well, especially the very hard γ-ray spectrum. However, our model requires a very large proton power to efficiently produce the γ-ray through proton–photon interactions.
Magnetic Braids in Eruptions of a Spiral Structure in the Solar Atmosphere

We report on high-resolution imaging and spectral observations of eruptions of a spiral structure in the transition region, which were taken with the Interface Region Imaging Spectrograph, and the Atmospheric Imaging Assembly (AIA) and the Helioseismic and Magnetic Imager (HMI) onboard the Solar Dynamics Observatory (SDO). The eruption coincided with the appearance of two series of jets, with velocities comparable to the Alfvén speeds in their footpoints. Several pieces of evidence of magnetic braiding in the eruption are revealed, including localized bright knots, multiple well-separated jet threads, transition region explosive events, and the fact that all three of these are falling into the same locations within the eruptive structures. Through analysis of the extrapolated 3D magnetic field in the region, we found that the eruptive spiral structure corresponded well to locations of twisted magnetic flux tubes with varying curl values along their lengths. The eruption occurred where strong parallel currents, high squashing factors, and large twist numbers were obtained. The electron number density of the eruptive structure is found to be ∼3 × 1012 cm−3, indicating that a significant amount of mass could be pumped into the corona by the jets. Following the eruption, the extrapolations revealed a set of seemingly relaxed loops, which were visible in the AIA 94 Å channel, indicating temperatures of around 6.3 MK. With these observations, we suggest that magnetic braiding could be part of the mechanisms explaining the formation of solar eruption and the mass and energy supplement to the corona.
*Racial and Ethnic Disparities in Advanced Science and Mathematics Achievement During Elementary School

We analyzed a population-based cohort (N = 10,922) to investigate the onset and stability of racial and ethnic disparities in advanced (i.e., above the 90th percentile) science and mathematics achievement during elementary school as well as the antecedent, opportunity, and propensity factors that explained these disparities. About 13% to 16% of White students versus 3% to 4% of Black or Hispanic students displayed advanced science or mathematics achievement during kindergarten. The antecedent factor of family socioeconomic status and the propensity factors of student science, mathematics, and reading achievement by kindergarten consistently explained whether students displayed advanced science or mathematics achievement during first, second, third, fourth, or fifth grade. These and additional factors substantially or fully explained initially observed disparities between Black or Hispanic and White students in advanced science or mathematics achievement during elementary school. Economic and educational policies designed to increase racial and ethnic representation in STEM course taking, degree completion, and workforce participation may need to begin by elementary school.
Mast Cell Specific Receptor Mrgprb2 Regulating Experimental Colitis is Associated with the Microbiota-Gut-Brain Axis

Purpose Ulcerative colitis (UC) patients have disturbances in the microbiota-gut-brain axis, and mast cells are important components of this axis. The mast cell-specific receptor Mrgprb2 has effects on host defense against bacterial infection and neurogenic inflammation, which may help mast cells act on the axis. This study analyzed how Mrgprb2 participates in the pathogenesis of UC by affecting the microbiota-gut-brain axis. Materials and Methods Mrgprb2 knockout (b2KO) mice and wild-type (WT) mice were fed 2% (w/v) dextran sulfate sodium (DSS) in drinking water for 7 days, which was then replaced with normal water for 14 days. This cycle was repeated three times. Feces were collected on Days 21, 42, and 63 for intestinal microbiota analysis, and mice were euthanized on Day 64. Hypothalamus, amygdala and colon tissues were removed and analyzed. Results Compared with WT mice, B2KO mice exhibited increased weight loss, colon shortening and colonic pathological damage after colitis induction. Analysis of the intestinal microbiota showed that b2KO mice with colitis had a significant decrease in the abundance and diversity, as well as an increase in Allobaculum and a decrease in norank_f__Muribaculaceae and Ileibacterium. In colon tissues, the expression of mucin 2 (MUC2) and junctional adhesion molecule A (JAM-A) in b2KO mice was reduced, and oxidative stress levels were higher. B2KO mice with colitis had higher corticotropin-releasing hormone (CRH), corticotropin-releasing hormone receptor 1 (CRHR1), neuropeptide Y (NPY) and brain-derived neurotrophic factor (BDNF) mRNA levels in hypothalamus tissues and glucocorticoid receptor mRNA levels in the amygdala. Conclusion In the microbiota-gut-brain axis, Mrgprb2 was involved in regulating the intestinal microbiota composition, intestinal barrier and oxidative stress levels, and was related to stress regulation, which might help to explain the pathogenesis of UC.
An observational test for correlations between cosmic rays and magnetic fields

We derive the magnitude of fluctuations in total synchrotron intensity in the Milky Way, both from observations and from theory under various assumption about the relation between cosmic rays and interstellar magnetic fields. Given the relativ e magnitude of the fluctuations in the Galactic magnetic field suggested by the Faraday rotatio n and polarization data, the observations are inconsistent with local energy equipartiti on between cosmic rays and magnetic fields. Our analysis of synchrotron fluctuations suggests th at the distribution of cosmic rays is nearly uniform at scales of order 100pc, in contrast to that of the interstellar magnetic field. A conservative upper limit on the relative variations in the cosmic ray number density is 0.2‐0.4 at the scales of order 100 pc. Our results are consist ent with a mild anticorrelation between cosmic-ray and magnetic energy densities at these scales. Energy equipartition between cosmic rays and magnetic fields still may hold, but at scales e xceeding 1 kpc.
Quantitative Detection of Leishmania in Rhipicephalus microplus and Amblyomma sabanerae in the Peruvian Amazon Basin

Leishmaniasis is a disease of public importance with a complex transmission cycle. A quantitative PCR was developed by using the small subunit of the ribosomal RNA gene (SSU rRNA) as a DNA target, which is conserved in all Leishmania species. A TaqMan ® probe was designed to have a high specificity. In all, 22 out of 23 (95.7%) ticks classified as R. microplus tested positive for Leishmania sp. The quantification was between 34.1 and 2197.1 parasites per tick in a range of 12 to 769 fg/uL. In addition, 9 out of 10 (90%) ticks classified as Amblyomma sabanerae tested positive for Leishmania sp. The quantification was between 448.6 and 5428.6 parasites per tick in a range of 157 to 1900 fg/µL. Leishmania sp. was identified in very high percentages in Rhipicephalus microplus and Amblyomma sabanerae from wild Pecari tajacu and Chelonoidis denticulata, in quantities of 34.1 and 5428.6 parasites per arthropod, and this could suggest that the ticks were parasitized by sucking blood from the animals from which they were collected. This is the first report about Leishmania parasites found in wild Rhipicephalus microplus and Amblyomma sabanerae, adding new information about the distribution and epidemiology of the parasite in sylvatic areas.
Linear perturbation theory for tidal streams and the small-scale CDM power spectrum

Tidal streams in the Milky Way are sensitive probes of the population of dark-matter subhalos predicted in cold-dark-matter (CDM) simulations. We present a new calculus for computing the effect of subhalo fly-bys on cold tidal streams based on the action-angle representation of streams. The heart of this calculus is a line-of-parallel-angle approach that calculates the perturbed distribution function of a given stream segment by undoing the effect of all impacts. This approach allows one to compute the perturbed stream density and track in any coordinate system in minutes for realizations of the subhalo distribution down to 10^5 Msun, accounting for the stream's internal dispersion and overlapping impacts. We study the properties of density and track fluctuations with suites of simulations. The one-dimensional density and track power spectra along the stream trace the subhalo mass function, with higher-mass subhalos producing power only on large scales, while lower mass subhalos cause structure on smaller scales. The time-dependence of impacts and of the evolution of the stream after an impact gives rise to bispectra. We further find that tidal streams are essentially corrugated sheets in the presence of subhalo perturbations: different projections of the track all reflect the same pattern of perturbations, facilitating their observational measurement. We apply this formalism to density data for the Pal 5 stream and make a first rigorous determination of 10^{+11}_{-6} dark-matter subhalos with masses between 3x10^6 and 10^9 Msun within 20 kpc from the Galactic center (corresponding to 1.4^{+1.6}_{-0.9} times the number predicted by CDM-only simulations or to f_{sub}(r<20 kpc) ~ 0.2%). Improved data will allow measurements of the subhalo mass function down to 10^5 Msun, thus definitively testing whether dark matter clumps on the smallest scales relevant for galaxy formation.
Description of heavy deformed nuclei within the pseudo-SU(3) shell model

We present a review of the pseudo-SU(3) shell model and its application to heavy deformed nuclei. The model have been applied to describe the low energy spectra, B(E2) and B(M1) values. A systematic study of each part of the interaction within the Hamiltonian was carried out. The study leads us to a consistent method of choosing the parameters in the model. A systematic application of the model for a sequence of rare earth nuclei demonstrates that an overarching symmetry can be used to predict the onset of deformation as manifested through low-lying collective bands. The scheme utilizes an overarching sp(4, R) algebraic framework.
Clonostachys rosea Promotes Root Growth in Tomato by Secreting Auxin Produced through the Tryptamine Pathway

Clonostachys rosea (Link) Schroers is a filamentous fungus that has been widely used for biological control, biological fermentation, biodegradation and bioenergy. In this research, we investigated the impact of this fungus on root growth in tomato and the underlying mechanisms. The results showed that C. rosea can promote root growth in tomato, and tryptophan enhances its growth-promoting impacts. The results also showed that tryptophan increases the abundance of metabolites in C. rosea, with auxin (IAA) and auxin-related metabolites representing a majority of the highly abundant metabolites in the presence of tryptophan. It was noted that C. rosea could metabolize tryptophan into tryptamine (TRA) and indole-3-acetaldehyde (IAAId), and these two compounds are used by C. rosea to produce IAA through the tryptamine (TAM) pathway, which is one of the major pathways in tryptophan-dependent IAA biosynthesis. The IAA produced is used by C. rosea to promote root growth in tomato. To the best of our knowledge, this is the first report on IAA biosynthesis by C. rosea through the TAM pathway. More research is needed to understand the molecular mechanisms underlying IAA biosynthesis in C. rosea, as well as to examine the ability of this fungus to boost plant development in the field.
The role of window length and shift in complex-domain DNN-based speech enhancement

Deep learning techniques have widely been applied to speech enhancement as they show outstanding modeling capabilities that are needed for proper speech-noise separation. In contrast to other end-to-end approaches, masking-based meth-ods consider speech spectra as input to the deep neural network, providing spectral masks for noise removal or attenuation. In these approaches, the Short-Time Fourier Transform (STFT) and, particularly, the parameters used for the analysis/synthesis window, plays an important role which is often neglected. In this paper, we analyze the effects of window length and shift on a complex-domain convolutional-recurrent neural network (DCCRN) which is able to provide, separately, magnitude and phase corrections. Different perceptual quality and intelligibility objective metrics are used to assess its performance. As a result, we have observed that phase corrections have an increased impact with shorter window sizes. Similarly, as window overlap increases, phase takes more relevance than magnitude spectrum in speech enhancement.
Prevalence and risk factors for persistent atrial fibrillation in obstructive sleep apnea

Objectives Obstructive sleep apnea (OSA) is a common cause of atrial fibrillation (AF). The prevalence rate of OSA in AF is highest at 80%. There is limited data if who will develop AF in OSA patients. This study aimed to evaluate the prevalence of AF in patients with OSA and find clinical factors predictive of AF in patients with OSA. Material and Methods This was a cross-sectional study. We enrolled consecutive patients diagnosed with obstructive sleep apnea diagnosed by polysomnography. The primary outcome was persistent AF identified by electrocardiogram. Prevalence and predictors of AF in patients with OSA were analyzed. Results During the study period, there were 199 patients with OSA enrolled in the study. Of those, 31 patients (15.57%) had AF. There were five factors in the final model predictive for AF in OSA patients. Among those factors, three factors were independently associated with AF in OSA including age, tiredness, and glomerular filtration rate. The latter two factors were protective factors, while age was a predictor for AF with an adjusted odds ratio (95% confidence interval) of 1.052 (1.004, 1.103). Conclusion The prevalence of AF in patients with OSA was 15.57%. Elderly patients with renal deterioration are at risk of AF but AF risk was decreasing in patients with tiredness.
Appearance of Boulware-Deser ghost in bigravity with doubly coupled matter

We discuss the ghost freeness in the case when we add matter coupled to two metrics to the ghost-free bigravity. In this paper we show that the Boulware-Deser ghost generally revives in the presence of doubly coupled matter and that ghost freeness strongly restricts the model of kinetically doubly coupled matter. This result may anticipate difficulties in the attempt to derive the ghost-free bigravity as a low-energy effective theory, starting with a model applicable at high energies.
THE TALE OF THE TWO TAILS OF THE OLDISH PSR J2055+2539

We analyzed a deep XMM-Newton observation of the radio-quiet γ-ray PSR J2055+2539. The spectrum of the X-ray counterpart is nonthermal, with a photon index of Γ = 2.36 ± 0.14 (1σ confidence). We detected X-ray pulsations with a pulsed fraction of 25% ± 3% and a sinusoidal shape. Taking into account considerations on the γ-ray efficiency of the pulsar and on its X-ray spectrum, we can infer a pulsar distance ranging from 450 to 750 pc. We found two different nebular features associated with PSR J2055+2539 and protruding from it. The angle between the two nebular main axes is ∼162. °8 ± 0. °7. The main, brighter feature is 12′ long and <20″ thick, characterized by an asymmetry with respect to the main axis that evolves with the distance from the pulsar, possibly forming a helical pattern. The secondary feature is 250″ × 30″. Both nebulae present an almost flat brightness profile with a sudden decrease at the end. The nebulae can be fitted by either a power-law model or a thermal bremsstrahlung model. A plausible interpretation of the brighter nebula is in terms of a collimated ballistic jet. The secondary nebula is most likely a classical synchrotron-emitting tail.
No Significant Differences in Clinical and Radiographic Outcomes between PCL Retained or Sacrificed Kinematic Aligned Medial Pivot Total Knee Arthroplasty in Varus Knee

In the last decades, several surgical techniques, such as medial pivot (MP) philosophy and kinematic alignment (KA), have been introduced in total knee arthroplasty (TKA) to improve patients’ outcomes. This retrospective study aims to evaluate the clinical, radiographic, and functional results of PCL preservation or sacrifice in KA MP-TKA. A consecutive series of 147 patients older than 60, with a minimum follow-up of two years, were treated with TKA for severe primary knee osteoarthritis (OA) at the Department of Orthopedics and Traumatology between 1 January 2019, and 1 July 2020. After excluding those not meeting the inclusion criteria, 64 patients were included in the study analysis. Regarding radiographic outcomes, no statistically significant difference was observed between patients with preserved or sacrificed PCL (p > 0.05). A slight improvement in Knee Society Score (KSS), knee and function score, and FJS was observed for the PCL-preserved group, although this superiority tendency was not statistically significant (p > 0.05). PCL-preserved MA MP-TKA reported a statistically significant result in only two questions on the FJS questionnaire (p < 0.05). A slight, non-statistically significant improvement in active ROM was found in the PCL-sacrificed group (p > 0.05). No interventions or revisions were reported in this case series for all treated patients at the final follow-up. No significant differences were described in clinical, radiographic, and functional outcomes in preserved or sacrificed PCL KA MP-TKA. Although not significant, a slight trend toward better clinical outcomes was reported in PCL-preserved KA MP-TKA.
New Positive TRPC6 Modulator Penetrates Blood–Brain Barrier, Eliminates Synaptic Deficiency and Restores Memory Deficit in 5xFAD Mice

Synapse loss in the brain of Alzheimer’s disease patients correlates with cognitive dysfunctions. Drugs that limit synaptic loss are promising pharmacological agents. The transient receptor potential cation channel, subfamily C, member 6 (TRPC6) regulates the formation of an excitatory synapse. Positive regulation of TRPC6 results in increased synapse formation and enhances learning and memory in animal models. The novel selective TRPC6 agonist, 3-(3-,4-Dihydro-6,7-dimethoxy-3,3-dimethyl-1-isoquinolinyl)-2H-1-benzopyran-2-one, has recently been identified. Here we present in silico, in vitro, ex vivo, pharmacokinetic and in vivo studies of this compound. We demonstrate that it binds to the extracellular agonist binding site of the human TRPC6, protects hippocampal mushroom spines from amyloid toxicity in vitro, efficiently recovers synaptic plasticity in 5xFAD brain slices, penetrates the blood–brain barrier and recovers cognitive deficits in 5xFAD mice. We suggest that C20 might be recognized as the novel TRPC6-selective drug suitable to treat synaptic deficiency in Alzheimer’s disease-affected hippocampal neurons.
A moving magnetic trap decelerator: a new source of cold atoms and molecules

We present an experimental realization of a moving magnetic trap decelerator, where paramagnetic particles entrained in a cold supersonic beam are decelerated in a co-moving magnetic trap. Our method allows for an efficient slowing down of both paramagnetic atoms and molecules to near stopping velocities. We show that under realistic conditions we will be able to trap and decelerate a large fraction of the initial supersonic beam. We present our first results on deceleration in a moving magnetic trap by bringing metastable neon atoms to near rest. Our estimated phase space volume occupied by decelerated particles at a final velocity of 50 m s−1 shows an improvement of two orders of magnitude as compared to currently available deceleration techniques.
Electron temperature and tunnel coupling dependence of zero-bias and almost-zero-bias conductance peaks in Majorana nanowires

A one-dimensional semiconductor nanowire proximitized by a nearby superconductor may become a topological superconductor hosting localized Majorana zero modes at the two wire ends in the presence of spin-orbit coupling and Zeeman spin splitting (arising from an external magnetic field). The hallmark of the presence of such Majorana zero modes is the appearance of a zero-temperature quantized zero-bias conductance peak in the tunneling spectroscopy of the Majorana nanowire. We theoretically study the temperature and the tunnel coupling dependence of the tunneling conductance in such nanowires to understand possible intrinsic deviations from the predicted conductance quantization. We find that the full temperature and the tunneling transmission dependence of the tunnel conductance does not obey any simple scaling relation, and estimating the zero-temperature conductance from finite-temperature and finite-tunnel-broadening tunneling data is difficult in general. A scaling relation, however, does hold at the extreme weak-tunneling low-temperature limit where the conductance depends only on the dimensionless ratio of the temperature and tunnel broadening. We also consider the tunneling contributions from nontopological Andreev bound states which may produce almost-zero-bias conductance peaks, which are not easy to distinguish from the Majorana-induced zero-bias peaks, finding that the nontopological almost-zero-modes associated with Andreev bound states manifest similar temperature and transmission dependence as the topological Majorana modes. We comment on the Zeeman splitting dependence of the zero-bias conductance peak for finite temperature and tunnel coupling.
The nature of the intra-night optical variability in blazars

In this paper we present the results of a short-term optical monitoring program of 13 blazars. The objects were monitored mostly in the R band for a total of ∼160 h between 2006 and 2011. We study the nature of the short-term variations and show that most of them could be described as slow, smooth and (almost) linear changes of up to ∼0.1 mag h −1 , but that many objects show no short-term variations at all. In fact, we found only a ∼2 per cent chance of observing variability of more than 0.1 mag h −1 for the sample we observed. Hints of quasiperiodic oscillations at very low-amplitude levels are also found for some objects. We briefly discuss some of the possible mechanisms for generating the intra-night variability and the quasi-periodic oscillations.