Miracle-dz/UniFAR-FTUs huggingface dataset:
Reshaping Treatment of Heart Failure with Preserved Ejection Fraction

Current data indicate that in the community, approximately 50% of patients with heart failure (HF) have preserved left ventricular (LV) ejection fraction (LVEF)—the so-called HFpEF. Treatment of HFpEF has been considered an unmet need for decades. We believe that the main underlying reasons have been (a) the ever-changing LVEF cut-offs used for HF classification; (b) controversies regarding the definition of the LVEF normal range; (c) the fact that HFpEF does not represent a phenotype, but a category of diseases with entirely different characteristics (hypertensive heart disease, valvular heart disease (VHD), hypertrophic cardiomyopathy (HCM) etc.); (d) the lack of recognition that hypertensive HFpEF is the most common and important HFpEF phenotype; (e) the assumption that neurohormonal overactivity is absent in HF patients with a LVEF > 45–50% which has been proven to be wrong. Current HFpEF trials, in which the vast majority of the participants suffered from hypertension (HTN), whereas VHD and HCM were absent, demonstrated that neurohormonal and sodium-glucose cotransporter 2 (SGLT2) inhibitors are effective in HF patients over a wide LVEF range. Thus, restricting these lifesaving treatments to HF patients with reduced LVEF is not justified anymore and it should be additionally considered for HFpEF patients suffering from HTN.
Geraniol as a Potential Stimulant for Improving Anthocyanin Accumulation in Grape Berry Skin through ABA Membrane Transport

Climate change, particularly warmer temperature, has resulted in reduced anthocyanin accumulation in grape berry skin. Because anthocyanin is a crucial determinant of red wine quality, viticulturists need to devise a solution for mitigating the poor coloration of red/black grape berry skin under elevated temperature conditions. In this study, we investigated the effects of geraniol on anthocyanin accumulation in grape berry skins of field-grown grapevines and elucidated the molecular mechanisms of the geraniol-triggered anthocyanin accumulation. Geraniol-treated bunches showed enhanced anthocyanin accumulation in berry skins at harvest (50 days after treatment). Geraniol treatment upregulated the transcription of MybA1 and UFGT, which encode the key factors in anthocyanin biosynthesis, in berry skins. Geraniol treatment also improved anthocyanin accumulation in grape cultured cells. We isolated grape ATP-binding cassette transporter G family protein VvABCG40, encoding abscisic acid (ABA) membrane transporter, from geraniol-treated grape cultured cells. VvABCG40 transcription was upregulated in berry skins 40 days after treatment. Geraniol treatment also upregulated the transcription of VvPP2C24, which encodes ABA-responsible type 2C protein phosphatases, in berry skins, but not the transcription of VvNCED1, which encodes a key enzyme in ABA biosynthesis. Taken together, geraniol-triggered anthocyanin accumulation in berry skins is promoted by ABA membrane transport and not by ABA biosynthesis, and geraniol treatment of field-grown grape bunches may contribute to alleviating the poor coloration of berry skin as a novel technique in viticulture.
Méthodes anti-dissipatives pour les équations Hamilton Jacobi Bellman

On etudie la convergence d'un schema anti-dissipatif, l'UltraBee, pour les equations Hamilton Jacobi Bellman en dimension 1. Deux methodes de resolution utilisant ce schema sont proposees. La premiere combine l'UltraBee a une adaptation de grille, la deuxieme utilise un stockage creux. Cette derniere est appliquee au probleme de la rentree atmospherique. Enfin, quelques extensions theoriques sont donnees.
The Use of Indocyanine Green (ICG) and Near-Infrared (NIR) Fluorescence-Guided Imaging in Gastric Cancer Surgery: A Narrative Review

Near-infrared fluorescence imaging with indocyanine green is an emerging technology gaining clinical relevance in the field of oncosurgery. In recent decades, it has also been applied in gastric cancer surgery, spreading among surgeons thanks to the diffusion of minimally invasive approaches and the related development of new optic tools. Its most relevant uses in gastric cancer surgery are sentinel node navigation surgery, lymph node mapping during lymphadenectomy, assessment of vascular anatomy, and assessment of anastomotic perfusion. There is still debate regarding the most effective application, but with relatively no collateral effects and without compromising the operative time, indocyanine green fluorescence imaging carved out a role for itself in gastric resections. This review aims to summarize the current indications and evidence for the use of this tool, including the relevant practical details such as dosages and times of administration.
Systematic Identification of Genomic Markers for Guiding Iron Oxide Nanoparticles in Cervical Cancer Based on Translational Bioinformatics

Purpose Magnetic iron oxide nanoparticle (MNP) drug delivery system is a novel promising therapeutic option for cancer treatment. Material issues such as fabrication and functionalized modification have been investigated; however, pharmacologic mechanisms of bare MNPs inside cancer cells remain obscure. This study aimed to explore a systems pharmacology approach to understand the reaction of the whole cell to MNPs and suggest drug selection in MNP delivery systems to exert synergetic or additive anti-cancer effects. Methods HeLa and SiHa cell lines were used to estimate the properties of bare MNPs in cervical cancer through 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) and enzyme activity assays and cellular fluorescence imaging. A systems pharmacology approach was utilized by combining bioinformatics data mining with clinical data analysis and without a predefined hypothesis. Key genes of the MNP onco-pharmacologic mechanism in cervical cancer were identified and further validated through transcriptome analysis with quantitative reverse transcription PCR (qRT-PCR). Results Low cytotoxic activity and cell internalization of MNP in HeLa and SiHa cells were observed. Lysosomal function was found to be impaired after MNP treatment. Protein tyrosine kinase 2 beta (PTK2B), liprin-alpha-4 (PPFIA4), mothers against decapentaplegic homolog 7 (SMAD7), and interleukin (IL) 1B were identified as key genes relevant for MNP pharmacology, clinical features, somatic mutation, and immune infiltration. The four key genes also exhibited significant correlations with the lysosome gene set. The qRT-PCR results showed significant alterations in the expression of the four key genes after MNP treatment in HeLa and SiHa cells. Conclusion Our research suggests that treatment of bare MNPs in HeLa and SiHa cells induced significant expression changes in PTK2B, PPFIA4, SMAD7, and IL1B, which play crucial roles in cervical cancer development and progression. Interactions of the key genes with specific anti-cancer drugs must be considered in the rational design of MNP drug delivery systems.
Transcriptome and Quasi-Targeted Metabolome Analyze Overexpression of 4-Hydroxyphenylpyruvate Dioxygenase Alleviates Fungal Toxicity of 9-Phenanthrol in Magnaporthe oryzae

Magnaporthe oryzae, the causal agent of rice blast disease, produces devastating damage to global rice production. It is urgent to explore novel strategies to overcome the losses caused by this disease. 9-phenanthrol is often used as a transient receptor potential melastatin 4 (TRPM4) channel inhibitor for animals, but we found its fungal toxicity to M. oryzae. Thus, we explored the antimicrobial mechanism through transcriptome and metabolome analyses. Moreover, we found that overexpression of a gene encoding 4-hydroxyphenylpyruvate dioxygenase involved in the tyrosine degradative pathway enhanced the tolerance of 9-phenanthrol in M. oryzae. Thus, our results highlight the potential fungal toxicity mechanism of 9-phenanthrol at metabolic and transcriptomic levels and identify a gene involving 9-phenanthrol alleviation. Importantly, our results demonstrate the novel mechanism of 9-phenanthrol on fungal toxicity that will provide new insights of 9-phenanthrol for application on other organisms.
Effects of Compounds Isolated from Lindera erythrocarpa on Anti-Inflammatory and Anti-Neuroinflammatory Action in BV2 Microglia and RAW264.7 Macrophage

Lindera erythrocarpa contains various constituents such as cyclopentenedione-, flavonoid-, and chalcone-type components. In this study, a novel bi-linderone derivative and 17 known compounds were isolated from the leaves of L. erythrocarpa by using various chromatographic methods. The structures of the components were determined from nuclear magnetic resonance and mass spectrometry data. All isolated compounds were tested for anti-inflammatory and anti-neuroinflammatory activities in lipopolysaccharide (LPS)-induced BV2 and RAW264.7 cells. Some of these compounds showed anti-inflammatory effects by inhibiting the nitric oxide (NO) produced by LPS. In particular, linderaspirone A (16), bi-linderone (17) and novel compound demethoxy-bi-linderone (18) showed significant inhibitory effects on the production of prostaglandin E2 (PGE2), tumor necrosis factor-α, and interleukin-6. The three compounds also inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), which are pro-inflammatory proteins, and the activation of nuclear factor κB (NF-κB). Therefore, linderaspirone A (16), bi-linderone (17), and demethoxy-bi-linderone (18) isolated from the leaves of L. erythrocarpa have therapeutic potential in neuroinflammatory diseases.
Fully Coupled Analysis of an Integrated Floating Wind-Wave Power Generation Platform in Operational Sea-States

The offshore wind power exploitation has experienced rapid development in recent years and has gradually moved into deeper waters with the floating wind turbine technology getting mature. Due to the strong concurrence of the wind and wave power in offshore sites, the idea of combined utilization of wind and wave power by one integrated device has attracted tremendous interests worldwide and a number of concepts and designs have been proposed. This article describes a novel integrated floating wind-wave generation platform (FWWP) consisting of a DeepCwind semi-submersible floating offshore wind turbine (FOWT) and a point absorber wave energy convertor (PAWEC). Three models including the single PAWEC, single FOWT, and FWWP are considered to investigate the feasibility of the FWWP and its advantages over the single device. Hydrodynamic analyses are first conducted using the potential flow code AQWA with the viscous correction to investigate the hydrodynamic interactions effect of the integrated model. Then, a fully coupled model for the FWWP is established by calling OpenFAST in AQWA using the F2A method. The accuracy of the established coupled model is firstly validated with OpenFAST for analysing the dynamics of the single FOWT. Finally, fully coupled analyses of the FWWP are carried out for both regular and irregular waves in the operational sea-states. The coupled dynamics and wind and wave power generation of the FWWP are compared with those of the single PAWEC and FOWT for both the regular and irregular waves.
On the Use of Supercapacitors for DC Blocking in Transformer-Coupled Voltage Amplifiers for Low-Frequency Noise Measurements

When performing low-frequency noise measurements on low-impedance electron devices, transformer coupling can be quite effective in reducing the contribution of the equivalent input noise voltage of the preamplifier to the background noise of the system. However, noise measurements on electron devices are usually performed with a biased device under test. A bridge configuration must be used to null the DC component at the input of the transformer. Unfortunately, using a bridge results in a complication of the set-up and degradation of the system’s sensitivity because of the noise introduced by the nulling arm. We propose an alternative approach for blocking the DC component that exploits the fact that supercapacitors with capacitances in excess of a few Farads are nowadays easily available. Actual measurement results in conventional and advanced measurement configurations are discussed that demonstrate the advantages of the approach we propose.
Self‐admitted technical debt detection by learning its comprehensive semantics via graph neural networks

The goal of software development is to deliver software products with high quality and free from defects, but resource and time constraints often cause the developers to submit incomplete or temporary patches of codes and further bear the additional burden. Therefore, the investigations on identifying self‐admitted technical debt (SATD) to improve code quality have been conducted in recent years. However, missing syntactic structure information and the imbalance distribution bias shorten the SATD identification performance. Addressing to this issue, we present a graph neural network based SATD identification model (GNNSI) to improve the performance. Specifically, we obtain the structure information of the missing SATD in a compositional way to obtain different feature maps for different comments, and use focal loss to handle the imbalance between SATD and non‐SATD classes in the comments. Then extensive experiments on 10 open source projects are conducted, and the results show that GNNSI outperforms the baselines and can help developers to better predict SATDs.
Transiting exoplanets from the CoRoT space mission. IV. CoRoT-Exo-4b: a transiting planet in a 9.2 d

CoRoT, the first space-based transit search, provides ultra-high precision light curves with continuous time-sampling over periods, of up to 5 months. This allows the detection of transiting planets with relatively long periods, and the simultaneous study of the host star's photometric variability. In this letter, we report on the discovery of the transiting giant planet CoRoT-Exo-4b and use the CoRoT light curve to perform a detailed analysis of the transit and to determine the stellar rotation period. The CoRoT light curve was pre-processed to remove outliers and correct for orbital residuals and artefacts due to hot pixels on the detector. After removing stellar variability around each transit, the transit light curve was analysed to determine the transit parameters. A discrete auto-correlation function method was used to derive the rotation period of the star from the out-of-transit light curve. We derive periods for the planet's orbit and star's rotation of 9.20205 +/- 0.00037 and 8.87 +/- 1.12 days respectively, consistent with a synchronised system. We also derive the inclination, i = 90.00 -0.085 +0.000 in degrees, the ratio of the orbital distance to the stellar radius, a/R_s = 17.36 -0.25 +0.05, and the planet to star radius ratio R_p/R_s = 0.1047 -0.0022 +0.0041. We discuss briefly the coincidence between the orbital period of the planet and the stellar rotation period and its possible implications for the system's migration and star-planet interaction history.
Photothermal‐Amplified Single Atom Nanozyme for Biofouling Control in Seawater

Biofouling is a common and expensive problem in medical, food, and maritime industries. Artificial nanozymes as functional mimics of haloperoxidases that boost the formation of cytotoxic hypohalous acids from halides and H2O2 are showing increasing potential as a novel class of ecofriendly antibiofouling materials to combat biofilm formation. A photothermal nanozyme (Mo SA‐N/C) with Mo single atoms as active sites that exhibits haloperoxidase‐mimicking capacity is herein developed. Density functional theory calculations indicate that hydroxyl radical from H2O2 dissociation is the key intermediate for hypobromous acid formation. Upon photoirradiation, Mo SA‐N/C generates heat and accelerates the reaction kinetics substantially. Finally, it is demonstrated that Mo SA‐N/C exerts superior broad‐spectrum antibacterial activity and can be applied as an effective coating additive for inhibiting biofouling in real marine conditions. Taken together, this study opens an avenue for developing biocompatible and photo‐response artificial enzymes for our fight against marine biofouling.
Synthesis and Characterization of Hybrid Nanocomposites of Gold Nanostars Encapsulated on Graphene Oxide as Active SERS Nanotags

Hybrid nanocomposites of gold nanostars and graphene oxide exhibit intriguing optical and electrical properties derived from the sharp-tip effect of nanostars and the high conductivity of honeycomb structure from C-sp2 hybridization of graphene-based materials. This work presents a facile way to wrap graphene oxide nano-colloids surrounding the as-prepared gold nanostars via the assistance of linker molecules, 4-aminothiophenol, as effective nanotags. Upon tightly binding to the surface of gold nanostars via gold- thiol interactions, 4-aminothiophenol can modify the surface of gold nanostars positively charged originated from amine groups and thus facilitate the self-assembly of negatively charged graphene oxide to wrap around the surface of gold nanostars. The SEM, TEM images and the shift in the Uv-Vis spectra of the resulting gold nanostars- graphene oxide nanocomposites reveal the successful encapsulation. Besides, the enhanced Raman signal of 4-aminothiophenol highlights the potential of the obtained gold nanostars-graphene oxide hybrids as effective nanotags for applications in surface enhanced Raman scattering sensing and bio-imaging.
The Current State of Radiotherapy for Pediatric Brain Tumors: An Overview of Post-Radiotherapy Neurocognitive Decline and Outcomes

Tumors of the central nervous system are the most common solid malignancies diagnosed in children. While common, they are also found to have some of the lowest survival rates of all malignancies. Treatment of childhood brain tumors often consists of operative gross total resection with adjuvant chemotherapy or radiotherapy. The current body of literature is largely inconclusive regarding the overall benefit of adjuvant chemo- or radiotherapy. However, it is known that both are associated with conditions that lower the quality of life in children who undergo those treatments. Chemotherapy is often associated with nausea, emesis, significant fatigue, immunosuppression, and alopecia. While radiotherapy can be effective for achieving local control, it is associated with late effects such as endocrine dysfunction, secondary malignancy, and neurocognitive decline. Advancements in radiotherapy grant both an increase in lifetime survival and an increased lifetime for survivors to contend with these late effects. In this review, the authors examined all the published literature, analyzing the results of clinical trials, case series, and technical notes on patients undergoing radiotherapy for the treatment of tumors of the central nervous system with a focus on neurocognitive decline and survival outcomes.
SOX30 Overexpression Reflects Tumor Invasive Degree, Lymph Node Metastasis and Predicts Better Survival in Colorectal Cancer Patients: A Long-Term Follow-Up Cohort Study

Aims Sex-determining region Y-box containing gene 30 (SOX30) takes part in the progression of several cancers, while its clinical engagement in colorectal cancer (CRC) is obscure. Therefore, this study aimed to explore the association of SOX30 with clinicopathological features and prognosis in CRC patients. Methods Tumor and adjacent noncancerous specimens of 195 CRC patients who received resection were acquired. Furthermore, an immunohistochemistry assay was performed to detect SOX30 protein expression in these specimens; meanwhile, SOX30 mRNA expression was determined by reverse transcription-quantitative polymerase chain reaction assay in 95 out of 195 specimens. Moreover, clinical characteristics and survival data (follow-up duration median (range): 71.0 (7.0-95.0) months) of CRC patients were gathered. Results SOX30 protein and mRNA expressions were both decreased in CRC tumor tissue compared to adjacent tissue (both P < 0.001). Furthermore, a negative correlation was found in tumor SOX30 protein expression with tumor size (P = 0.049), lymph node (LYN) metastasis (P = 0.018), T stage (P = 0.001), N stage (P = 0.034), and TNM stage (P = 0.001); tumor SOX30 mRNA expression was also negatively correlated with LYN metastasis (P = 0.001), T stage (P = 0.019), N stage (P = 0.004), and TNM stage (P < 0.001). Furthermore, tumor SOX30 protein expression was positively correlated with overall survival (OS) (P = 0.017), while tumor SOX30 mRNA expression was not correlated with OS (P = 0.070). Multivariate Cox’s regression analysis illustrated that tumor SOX30 protein high expression was an independent factor for favorable OS (hazard ratio: 0.525, P = 0.034). Conclusions SOX30 has potential as a biomarker for the progression and prognostication of CRC, which might improve the management of CRC.
Crosstalk of RNA Adenosine Modification-Related Subtypes, Establishment of a Prognostic Model, and Immune Infiltration Characteristics in Ovarian Cancer

Background Four RNA adenosine modifications, including m6A, m1A, alternative polyadenylation, and adenosine-to-inosine RNA editing, have been identified as potentially valuable in influencing colorectal carcinogenesis, immune infiltration, and response to drug therapy. However, the regulatory mechanisms and clinical significance of these four RNA modifications in ovarian cancer (OC) remain unknown. Methods We comprehensively described the transcriptional and genetic modifications of 26 RNA modification “writers” in OC and assessed the expression patterns. We identified two RNA modification subtypes using an unsupervised clustering approach. Subsequently, using differentially expressed genes (DEGs) in both subtypes, we calculated RNA modification “writer” scores (RMW scores) to characterize the RNA modifications of single OC patients. RMW score-related gene expression was investigated by qRT-PCR. We explored the correlation between RMW score and clinical features, immune infiltration, and drug sensitivity. We drew a nomogram to more intuitively and accurately describe the application value of the RMW score. Results We found that molecular alterations in “writers” are strongly related to prognostic and immune-infiltrating features in OC patients. We identified two different clusters of RNA modifications. According to the immune infiltration characteristics in the two RNA modification isoforms, cluster A and cluster B can correspond to “hot” and “cold” tumors, respectively. With the median RMW score, we classified the patients into high- and low-score subgroups. A low RMW score was associated with good patient prognosis and lower immune infiltration. In addition, a low RMW score equated with a higher cancer stem cell index and a lower tumor mutation burden, which to some extent affected the sensitivity of patients to therapeutic drugs. Seven RMW score-related gene expressions were investigated by qRT-PCR in three OC cell lines. Compared to previously known models, our established RMW score has higher accuracy in predicting patient survival. Conclusion A comprehensive analysis of four RNA modification patterns in OC reveals their potential value in OC prognosis, immune microenvironment, and drug sensitivity. These results could deepen our knowledge of RNA modification and yield fresh insights for new personalized therapeutic strategies.
An Update on the Key Factors Required for Plant Golgi Structure Maintenance

Plant Golgi apparatus serves as the central station of the secretory pathway and is the site where protein modification and cell wall matrix polysaccharides synthesis occur. The polarized and stacked cisternal structure is a prerequisite for Golgi function. Our understanding of Golgi structure maintenance and trafficking are largely obtained from mammals and yeast, yet, plant Golgi has many different aspects. In this review, we summarize the key players in Golgi maintenance demonstrated by genetic studies in plants, which function in ER-Golgi, intra-Golgi and post-Golgi transport pathways. Among these, we emphasize on players in intra-Golgi trafficking.