Miracle-dz/UniFAR-FTUs huggingface dataset:
A New Quasi-Horizontal Glider to Measure Biophysical Microstructure

This study describes the development of a new tethered quasi-horizontal microstructure profiler: the Turbulence Ocean Microstructure Acquisition Profiler‐Glider [TurboMAP-Glider (TMG)]. It is a unique instrument, capable of measuring ocean microstructure (temperature and turbulent velocity shear), chlorophyll, and turbidity simultaneously through a quasi-horizontal perspective. Three field experiments were carried out near Joga-shima, Japan, to test the TMG flight performance, and those results as well as comparisons with a laser-based vertical profiler, TurboMAP-L (TM), are described here. The TMG was capable of flying with an angle of attack of less than 258 and was reasonably stable for up to 300m horizontally over 100-m depth. Some new and relevant empirical results about quasi-horizontal application of high-resolution chlorophyll-afluorescencesensorsarepresented.TheratiobetweentheThorpelengthscaleandtheOzmidov lengthscalewasusedasatracertodemonstratethatmostoftheTMGdensityinversions areduetohorizontal variability and not to vertical overturning. These waveform structures are probably due to the horizontal inhomogeneity of the density field and are likely caused by internal waves.
On Multiplicities of Maximal Weights of (cid:2) sl(n) -Modules

We determine explicitly the maximal dominant weights for the integrable highest weight (cid:2) sl(n) -modules V ((k − 1 )Λ 0 + Λ s ) , 0 ≤ s ≤ n − 1, k ≥ 2. We give a conjecture for the number of maximal dominant weights of V (kΛ 0 ) and prove it in some low rank cases. We give an explicit formula in terms of lattice paths for the multiplicities of a family of maximal dominant weights of V (kΛ 0 ) . We conjecture that these multiplicities are equal to the number of certain pattern avoiding permutations. We prove that the conjecture holds for k = 2 and give computational evidence for the validity of this conjecture for k > 2.
ACOUSTIC ATTENUATION IN VERY SHALLOW WATER DUE TO THE PRESENCE OF BUBBLES IN RIP CURRENTS

An experiment was performed just off the research pier at the Scripps Institute of Oceanography to determine the acoustic effects of small bubbles in very shallow water (∼6 m depth). The distance offshore was ∼300 m. The propagation lengths were 2–10 m, and the frequency range was from 39 to 244 kHz. During the experiment, rip currents passed through the field of measurement instruments. These rip currents were laden with bubbles created in the surf between the instruments and the shore. The effects of these rip currents on the spatial distributions of the resulting acoustic attenuation are discussed. From the attenuation data, the bubble distributions are calculated using a new iterative approach [Caruthers et al., in press, J. Acoust. Soc. Am. ] that is based on the well-known resonant bubble approximation. Calculated bubble distributions varied from an essentially uniform lack of bubbles during quiescent periods to highly inhomogeneous and dense bubbly regions within rip events. Such observed distributi.
Voltage-mode multifunction ﬁlter with mutually independent Q and x 0 control feature using VDDDAs

The paper focuses on the application possibilities of the newly presented voltage differencing active building block called voltage differencing differential difference ampliﬁer. Using this active element, a multifunction frequency ﬁlter is designed featuring the possibility of mutually independent control of quality factor Q and characteristic frequency x 0 by means of active elements. The structure of the ﬁlter is based on the idea of the Akerberg-Mossberg (AM) ﬁlter, i.e. the integrators in the structure are always realized only by two active elements. This fact results in better phase compensation for the ﬁlter. Compared to the AM opamp based ﬁlter, the newly proposed structure features high-impedance inputs, low-impedance output, and all basic frequency responses. The performance of the proposed structure has been veriﬁed by SPICE simulations using the TSMC 0 : 18 l m level-7
The Exact Likelihood Ratio Test for Equality of Two Normal Populations

Testing the equality of two independent normal populations is a perfect case of the two-sample problem, yet it is not treated in the main text of any textbook or handbook. In this article, we derive the exact distribution of the likelihood ratio test and implement this test with an R function. This article has supplementary materials online.
The Braer storm revisited

The Braer storm of January 1993 was the deepest ever recorded cyclone outside of the Tropics with a minimum core pressure of 914mbar, but due to its track between Scotland and Iceland it caused little damage and was never intensively examined. Here we present a study of the dynamics of the storm using modern re‐analysis data from the European Centre for Medium‐Range Weather Forecasts (ECMWF) and sensitivity studies with the Weather Research and Forecasting (WRF) model to quantify influences of diabatic heating and Greenland's topography on the track and rapid deepening of the storm.
Adaptive Smoothing and Density-Based Tests of Multivariate Normality

Abstract Methods of adaptive smoothing of density estimates, where the amount of smoothing applied varies according to local features of the underlying density, are investigated. The difficulties of applying Taylor series arguments in this context are explored. Simple properties of the estimates are investigated by numerical integration and compared with the fixed kernel approach. Optimal smoothing strategies, based on the multivariate Normal distribution, are derived. As an application of these techniques, two tests of multivariate Normality—one based on integrated squared error and one on entropy—are developed, and some power calculations are carried out.
On testing nonnegativity of principal minors of Z-matrices using simplex method

A real square matrix is a Z -matrix if it’s off diagonal elements are nonpositive. A Z -matrix with nonnegative principal minors is called an M -matrix. The problem of testing whether a given matrix is an M -matrix or not is an important research problem in matrix theory as M -matrices arise naturally in a wide range of applications including ﬁnite difference methods for partial differential equations, input-output models in economics, linear complementarity problems in operations research, and Markov processes in probability and statistics. In this paper, we present a polynomial-time algorithm for testing whether a Z -matrix is an M -matrix based on modiﬁed simplex method.
Wave-particle duality? not in optical computing

Metaphysics has only one absolute requirement: It must account for the known physics. But many metaphysics account for light and they cannot all be right. We have only one metaphysical principle that is widely accepted (Einstein's minimum simplicity rule) and it gives no one answer. Even if we could enforce it, how would we prove its validity without a (meta)3principle? People like me who work with light are never confused about whether we are dealing with a particle or a wave. I find it useful to view light in terms even broader than the usual wave-particle description. I add a third kind of wave that is not measurable but also not restricted by the physics of the measurable. I find it difficult to account for light any other way.
Transforming Health Data to Actionable Information: Recent Progress and Future Opportunities in Health Information Exchange

Summary Objectives : Provide a systematic review of literature pertaining to health information exchange (HIE) since 2018. Summarize HIE-associated literature for most frequently occurring topics, as well as within the context of the COVID-19 pandemic and health equity. Finally, provide recommendations for how HIE can advance the vision of a digital healthcare ecosystem. Methods : A computer program was developed to mediate a literature search of primary literature indexed in MEDLINE that was: (1) indexed with “Health Information Exchange” MeSH descriptor as a major topic; and (2) published between January 2018 and December 2021. Frequency of MeSH descriptors was then used to identify and to rank topics associated with the retrieved literature. COVID-19 literature was identified using the general COVID-19 PubMed Clinical Query filter. Health equity literature was identified using additional MeSH descriptor-based searches. The retrieved literature was then reviewed and summarized. Results : A total of 256 articles were retrieved and reviewed for this survey. The major thematic areas summarized were: (1) Information Dissemination; (2) Delivery of Health Care; (3) Hospitals; (4) Hospital Emergency Service; (5) COVID-19; (6) Health Disparities; and (7) Computer Security and Confidentiality. A common theme across all areas examined for this survey was the maturity of HIE to support data-driven healthcare delivery. Recommendations were developed based on opportunities identified across the reviewed literature. Conclusions : HIE is an essential advance in next generation healthcare delivery. The review of the recent literature (2018-2021) indicates that successful HIE improves healthcare delivery, often resulting in improved health outcomes. There remain major opportunities for expanded use of HIE, including the active engagement of clinical and patient stakeholders. The maturity of HIE reflects the maturity of the biomedical informatics and health data science fields.
Consumer Health Informatics for Racial and Ethnic Minoritized Communities: Minor Progress, Major Opportunities

Summary Objective : By reducing barriers to accessing health services and by supporting health management, consumer health informatics has the potential to reduce health disparities. Yet, technologies are still being designed without considerations for racial and ethnic minoritized populations. This paper reviews consumer health informatics research within this population to assess for whom and how such technologies are being designed. Methods : We searched four databases from January 2020- December 2021 for literature focused on consumer health informatics and racial and ethnic minoritized populations. We extracted information about the study population, geographic location, stage of the design lifecycle, culturally tailored approaches, community engagement strategies, and considerations for the social determinants of health. Results : Twenty articles were included in the review. Most of the included literature were original research articles that tested health management interventions focused on one racial or ethnic minoritized population primarily within a confined geographic area within the United States. Seven studies described the extent to which an intervention was culturally tailored, including modifying the content, interface, functionality, and platform. Community engagement strategies varied, but few articles employed robust approaches. Lastly, seven studies detailed considerations for the social determinants of health, including providing hardware to access interventions and incorporating information about community-based resources within an intervention. Conclusions : There has been moderate progress in consumer health informatics focused on racial and ethnic minoritized populations and many opportunities remain for these technologies to be used as an approach to address health disparities. Future research should utilize community engagement strategies to design interventions that are attune to multiple racial and ethnic minoritized populations across geographic regions in addition to numerous intersectional identities and multiple co-morbidities.
Transarterial Chemoembolization Combined with Immune Checkpoint Inhibitors Plus Tyrosine Kinase Inhibitors versus Immune Checkpoint Inhibitors Plus Tyrosine Kinase Inhibitors for Advanced Hepatocellular Carcinoma

Objective This study aimed to evaluate the effectiveness and safety of transarterial chemoembolization (TACE) in combination with immune checkpoint inhibitors (ICIs) plus tyrosine kinase inhibitors (TKIs) (TACE+IT) versus ICIs plus TKIs (IT) for advanced hepatocellular carcinoma (HCC). Materials and Methods Data of consecutive advanced HCC patients receiving TACE+IT or IT between January 2019 and December 2021 were included and were retrospectively analyzed. Propensity score matching (PSM) was performed to reduce bias due to confounding variables. The primary outcome of the study was overall survival (OS). The secondary outcomes were progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and adverse events (AEs), respectively. Results Sixty-four patients were enrolled in the study, among which 24 and 40 received TACE+IT and IT, respectively. The PSM cohort included 24 patients receiving TACE+IT (TACE+IT group) and 24 patients receiving IT (IT group) alone. During a median follow-up of 23 months, patients in TACE+IT group had significantly longer OS (median, 17.3 vs 11.8 months, P = 0.023), better ORR (41.7% vs 12.5%, P = 0.023) and DCR (79.2% vs 50.0%, P = 0.035) than those in the IT group, whereas a non-significant trend in PFS (median, 7.4 vs 6.7 months, P = 0.23) was observed. According to multivariable cox regression analysis, it was found that treatment modality was the only independent risk factor for OS (HR = 0.404, 95% CI = 0.179–0.911, P < 0.05). There were no remarkable differences in AEs associated with ICIs and TKIs between the two groups, with the exception of gastrointestinal reaction. Conclusion TACE combined with ICIs plus TKIs significantly improved OS, ORR, and DCR and showed a relatively longer PFS trend over ICIs combined with TKIs for advanced HCC.
Association of Blood Glucose Variability with Sepsis-Related Disseminated Intravascular Coagulation Morbidity and Mortality

Purpose Sepsis-related disseminated intravascular coagulation (DIC) is closely associated with poor prognosis and high mortality. Higher blood glucose (BG) variability indicates an increased risk of mortality in sepsis; however, its relationship with sepsis-related DIC has not been investigated. This study aimed to determine the association between glucose variability and sepsis-related DIC. Patients and Methods Patients with sepsis admitted to the intensive care unit were enrolled between October 2017 and January 2021. Baseline data and BG records from the first 72 h were collected. We calculated the glucose liability index (GLI), largest amplitude of glucose excursion, BG standard deviation, and coefficient of variation on days 1 and 3. The relationship between GLI and morbidity of sepsis-related DIC was explored using a competing risk model. In subgroup analysis, we divided patients with and without diabetes into three groups according to the BG range. Results Of the 238 patients enrolled, 28.2% developed DIC during hospitalization (n=67). GLI on day 3 was found to have the closest relationship with DIC incidence as it has the largest area under the ROC curve and the highest associated odds ratio of death per unit change (GLI3-day: AUC=0.891 OR=1.84), also independently increased the occurrence of DIC after adjusting for the competing risk of death (sub-distribution hazard ratios=1.866, p<0.01). In subgroup analysis, patients with diabetes had worse outcomes under hypoglycemia than under hyperglycemia. Patients without diabetes having stable BG had the best outcomes. Conclusion Our study suggested that a higher GLI in patients with sepsis at 72 h was independently associated with an increased risk of sepsis-related DIC, which was not associated with pre-existing diabetes.
Nonlinear and Quasi-Simplex Patterns in Latent Growth Models

In the SEM literature, simplex and latent growth models have always been considered competing approaches for the analysis of longitudinal data, even if they are strongly connected and both of specific importance. General dynamic models, which simultaneously estimate autoregressive structures and latent curves, have been recently proposed in the literature. We discuss the properties of Autoregressive Latent Trajectories (ALT) with the aim of deriving their relationship with nonlinear growth models. We show how the quasi-simplex part of the ALT admits an equivalent nonlinear growth representation. A simulation study is performed to examine how the relationship holds in the presence of polynomial and bounded growths over time, whereas an empirical application on student achievement highlights the usefulness of the equivalence. The evaluation of the formative process in the European University system has been assuming an ever increasing importance since the beginning of the Bologna process. In this context, the analysis of student performances and capabilities using different approaches plays a fundamental role.
KIN17 promotes cell migration and invasion through stimulating the TGF‐β/Smad2 pathway in hepatocellular carcinoma

KIN17 DNA and RNA binding protein (Kin17) is involved in the regulation of tumorigenesis of diverse human cancers. However, its role in the cancer progression and metastasis in hepatocellular carcinoma (HCC) remains largely unknown. Bioinformatics and immunohistochemistry staining were used to investigate the expression pattern of KIN17 and its prognostic value in HCC patients. The transwell, wound‐healing assay was employed to determine the effects of KIN17 on migration and invasion of HCC cells in vitro. The tail veins model was employed to determine the effects of KIN17 on lung metastasis in vivo. The biological mechanisms involved in cell migration and invasion regulated by KIN17 were determined with Western blot analysis method. KIN17 expression was significantly increased in HCC tissues compared with adjacent normal tissues, with particularly higher in portal vein tumor thrombus and intrahepatic metastasis tissues. Patients with higher KIN17 expression experienced poor overall and disease free survival. KIN17 knockdown in HuH7 and HepG2 cells significantly reduced cell migration and invasion abilities, whereas its overexpression promoted migration and invasion in MHCC‐97L and HepG2 cells in vitro and in vivo. In HuH7 and HepG2 cells, KIN17 knockdown inhibited the TGF‐β/Smad2 pathway. In contrast, KIN17 overexpression stimulated TGF‐β/Smad2 pathway in MHCC‐97L and HepG2 cells, along with the genes involved in the epithelial‐mesenchymal transition. These findings suggest that KIN17 promotes migration and invasion in HCC cells by stimulating the TGF‐β/Smad2 pathway. KIN17 could be a promising prognostic biomarker, as well as a potential therapeutic target in HCC.
Cell Behavior Changes and Enzymatic Biodegradation of Hybrid Electrospun Poly(3‐hydroxybutyrate)‐Based Scaffolds with an Enhanced Piezoresponse after the Addition of Reduced Graphene Oxide

This is the first comprehensive study of the impact of biodegradation on the structure, surface potential, mechanical and piezoelectric properties of poly(3‐hydroxybutyrate) (PHB) scaffolds supplemented with reduced graphene oxide (rGO) as well as cell behavior under static and dynamic mechanical conditions. There is no effect of the rGO addition up to 1.0 wt% on the rate of enzymatic biodegradation of PHB scaffolds for 30 d. The biodegradation of scaffolds leads to the depolymerization of the amorphous phase, resulting in an increase in the degree of crystallinity. Because of more regular dipole order in the crystalline phase, surface potential of all fibers increases after the biodegradation, with a maximum (361 ± 5 mV) after the addition of 1 wt% rGO into PHB as compared to pristine PHB fibers. By contrast, PHB‐0.7rGO fibers manifest the strongest effective vertical (0.59 ± 0.03 pm V−1) and lateral (1.06 ± 0.02 pm V−1) piezoresponse owing to a greater presence of electroactive β‐phase. In vitro assays involving primary human fibroblasts reveal equal biocompatibility and faster cell proliferation on PHB‐0.7rGO scaffolds compared to pure PHB and nonpiezoelectric polycaprolactone scaffolds. Thus, the developed biodegradable PHB‐rGO scaffolds with enhanced piezoresponse are promising for tissue‐engineering applications.
Effects of Combining Occupationally Relevant Physical and Cognitive Tasks. A Systematic Review

Abstract Objectives Physical and cognitive tasks occur together in many occupations. Previous reviews of combined tasks have mainly focused on their effects in a sports context. This review investigated to which extent combinations (concurrent or alternating) of occupationally relevant physical and cognitive tasks influence responses reflecting biomechanical exposure, stress, fatigue, performance, and well-being. Methods We searched Scopus, Pubmed, Cinahl, and Psychinfo for controlled experiments investigating the effects of combinations of occupationally relevant physical and cognitive tasks in participants aged 18 to 70. In total, we identified 12 447 records. We added recent papers that had cited these studies (n = 573) to arrive at a total of 13 020 publications. After screening for relevance, 61 studies remained, of which 57 were classified to be of medium or high quality. Of the 57 studies, 51 addressed concurrent tasks, 5 alternating tasks, and 1 both concurrent and alternating tasks. Results Most studies of concurrent physical and cognitive tasks reported negative effects, if numerically small, on indicators of biomechanical exposure, fatigue, and performance, compared to a physical task alone. Results were mixed for stress indicators, and well-being was too little studied to justify any conclusions. Effects depended on the tasks, including their intensity and complexity. Alternating physical and cognitive tasks did not appear to influence outcomes much, compared to having passive breaks in-between physical tasks. Conclusions The reviewed evidence indicated that concurrent physical and cognitive work tasks have negative, yet small effects on biomechanical indicators, fatigue and performance, compared to performing the physical task alone, but only if the physical task is intense, and the cognitive task is complex. Alternating between physical and cognitive tasks may have similar effects as breaking up physical tasks by passive breaks, but studies were few. Future studies should address ecologically valid combinations of physical and cognitive tasks, in particular in controlled field studies devoted to the long-term effects of combined work.
Evidence for Complementary and Alternative Therapies to Treat Glaucoma

ABSTRACT Complementary and alternative medicine is used by approximately 5% of patients with glaucoma, and examples include marijuana, Ginkgo biloba extract, bilberry fruit extract, and acupuncture. Systemic marijuana is not beneficial for glaucoma due to the short duration of action, the lack of evidence that it alters disease progression, and its negative side effect profile. Drops that affect the cannabinoid pathway are still being studied. Ginkgo biloba and bilberry fruit extracts have been shown to decrease oxidative stress and improve perfusion of the optic nerve head. However, these findings are inconsistent throughout the literature and the studies are small, which makes the overall evidence weak. There is no evidence that acupuncture alters glaucoma disease progression or causes a sustained decrease in intraocular pressure. In summary, the literature suggests that there are transient and/or theoretical benefits of complementary and alternative medicine for glaucoma care; however, the overall evidence to support their use is weak.
Pulsar polarization fluctuations. I. 1404 MHz statistical summaries.

Observations de polarisation des pulsations individuelles des 11 pulsars PSR 0525+21, PSR 0823+26, PSR 0834+06 a , PSR 0919+06, PSR 0950+08 a , PSR 1133+16, PSR 1237+25, PSR 1929+10 a , PSR 1944+17, PSR 2016+28 et PSR 2020+28 a , a 1404 MHz avec le telescope de 3,05 m d'Arecibo