Miracle-dz/UniFAR-FTUs huggingface dataset:
Functional Properties of Cancer Epithelium and Stroma-Derived Exosomes in Head and Neck Squamous Cell Carcinoma

Stroma–cancer cell crosstalk involves a complex signaling network that contributes to tumor progression, including carcinogenesis, angiogenesis, migration, invasion, and therapy resistance in cancers. Exosomes, as extracellular membranous nanovesicles released by almost all types of cells, including tumor cells and stromal cells, play a critical role in signal delivery and material communication, in which the characteristics of their parent cells are reflected. The tumor or stroma-derived exosomes mediate cell–cell communication in the tumor microenvironment by transporting DNA, RNA, proteins, lipids, and metabolites. Recent studies on head and neck squamous cell carcinoma (HNSCC) have demonstrated that tumor-derived exosomes support various tumor biological behaviors, whereas the functional roles of stroma-derived exosomes remain largely unknown. Although these exosomes are emerging as promising targets in early diagnosis, prognostic prediction, and pharmaceutical carriers for antitumor therapy, there are still multiple hurdles to be overcome before they can be used in clinical applications. Herein, we systematically summarize the promotive roles of the epithelium and stroma-derived exosomes in HNSCC and highlight the potential clinical applications of exosomes in the treatment of HNSCC.
The impact of corporate governance quality on capital structure choices: does national governance quality matter?

Abstract This research investigates the moderating effect of national governance quality on the corporate governance—capital structure decision relationship. Using an instrumental variable estimation technique to analyze a multinational dataset containing 23,142 firm-year observations of 3,270 firms in 59 economies from 2004 to 2014, we find evidence for the moderating role of national governance quality. Specifically, a well-functioning firm-level governance system tends to force managers to increase borrowing toward an optimal level for shareholders. The strength of the force, however, seems to decrease as national governance quality increases. Our findings suggest that a transparent and investor-friendly business environment created by the government may complement the firm-level corporate governance mechanism by reducing agency problems, thus reducing the need to use leverage as a tool to discipline managers. The results are robust to different proxies for national governance quality, corporate governance quality, and firm leverage.
Searching for New Genetic Biomarkers of Axial Spondyloarthritis

Background: Axial spondyloarthritis (axSpA) is a chronic inflammatory condition of the spine. In addition to musculoskeletal symptoms, there are also extra-articular manifestations. The aim of this study was to search for new biomarkers associated with the clinical presentation and treatment response in axSpA patients. Methods: In this study, 106 axSpA patients and 110 healthy controls were enrolled. Six single-nucleotide polymorphisms (SNPs) were selected for genotyping: ERAP1 rs2287987, ERAP2 rs2549782, TNF rs1800629, TNFRSF1A rs767455, TNFRSF1B rs1061622, and FCGR2A rs1801274. Participants were examined at baseline and after 12 and 24 weeks of anti-TNF therapy. Results: SNPs associated with high axSpA initial activity were TNFRSF1A rs767455 and TNFRSF1B rs1061622 (p < 0.008). The ERAP1 rs2287987 AA genotype was more frequently observed in patients with enthesitis (AA vs. G+, p = 0.049), while the TNFRSF1B rs1061622 GG genotype was more common in participants with uveitis (GG vs. TT, p = 0.042). Potential in predicting anti-TNF treatment response was demonstrated by ERAP1 rs2287987, ERAP2 rs2549782, TNFRSF1B rs1061622, and FCGR2A rs1801274. Conclusions: SNPs can be used to identify patients at risk of severe disease to initiate treatment earlier. Genetic testing will allow clinicians to choose the right drug for the patient.
Bioengineering Approaches for Delivering Growth Factors: A Focus on Bone and Cartilage Regeneration

Growth factors are bio-factors that target reparatory cells during bone regeneration. These growth factors are needed in complicated conditions of bone and joint damage to enhance tissue repair. The delivery of these growth factors is key to ensuring the effectiveness of regenerative therapy. This review discusses the roles of various growth factors in bone and cartilage regeneration. The methods of delivery of natural or recombinant growth factors are reviewed. Different types of scaffolds, encapsulation, Layer-by-layer assembly, and hydrogels are tools for growth factor delivery. Considering the advantages and limitations of these methods is essential to developing regenerative therapies. Further research can accordingly be planned to have new or combined technologies serving this purpose.
Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review

Chitosan (CS) is a linear polysaccharide obtained by the deacetylation of chitin, which, after cellulose, is the second biopolymer most abundant in nature, being the primary component of the exoskeleton of crustaceans and insects. Since joining the pharmaceutical field, in the early 1990s, CS attracted great interest, which has constantly increased over the years, due to its several beneficial and favorable features, including large availability, biocompatibility, biodegradability, non-toxicity, simplicity of chemical modifications, mucoadhesion and permeation enhancer power, joined to its capability of forming films, hydrogels and micro- and nanoparticles. Moreover, its cationic character, which renders it unique among biodegradable polymers, is responsible for the ability of CS to strongly interact with different types of molecules and for its intrinsic antimicrobial, anti-inflammatory and hemostatic activities. However, its pH-dependent solubility and susceptibility to ions presence may represent serious drawbacks and require suitable strategies to be overcome. Presently, CS and its derivatives are widely investigated for a great variety of pharmaceutical applications, particularly in drug delivery. Among the alternative routes to overcome the problems related to the classic oral drug administration, the mucosal route is becoming the favorite non-invasive delivery pathway. This review aims to provide an updated overview of the applications of CS and its derivatives in novel formulations intended for different methods of mucosal drug delivery.
Intraoperative Optical Monitoring of Spinal Cord Hemodynamics Using Multiwavelength Imaging System

The spinal cord is a major structure of the central nervous system allowing, among other things, the transmission of afferent sensory and efferent motor information. During spinal surgery, such as scoliosis correction, this structure can be damaged, resulting in major neurological damage to the patient. To date, there is no direct way to monitor the oxygenation of the spinal cord intraoperatively to reflect its vitality. This is essential information that would allow surgeons to adapt their procedure in case of ischemic suffering of the spinal cord. We report the development of a specific device to monitor the functional status of biological tissues with high resolution. The device, operating with multiple wavelengths, uses Near-InfraRed Spectroscopy (NIRS) in combination with other additional sensors, including ElectroNeuroGraphy (ENG). In this paper, we focused primarily on aspects of the PhotoPlethysmoGram (PPG), emanating from four different light sources to show in real time and record biological signals from the spinal cord in transmission and reflection modes. This multispectral system was successfully tested in in vivo experiments on the spinal cord of a pig for specific medical applications.
An Intervention of 12 Weeks of Nordic Walking and Recreational Walking to Improve Cardiorespiratory Capacity and Fitness in Older Adult Women

(1) Background: The main aim of this study was to examine the effect of an intervention of 12 weeks in three groups on anthropometric measurement and heart rate (HR) variables, fitness index, and maximal oxygen consumption (VO2max) in older women. (2) Methods: In total, 166 Serbian adult women, aged 50 to 69 years old, participated in this study, comprising a control group (60 participants, μage = 57.8 + 6.6), Nordic-walking (NW) group (53 participants, μage = 57.5 + 6.8), and recreational-walking (RW) group (53 participants, μage = 57.8 + 6.6) in a physical fitness programme for 12 weeks. (3) Results: Anthropometric measurement variables were measured using a stadiometer and an electronic scale. The data showed differences in walking heart rate (bt/min) (p < 0.001; η2 = 0.088) between control, NW, and RW groups in the pretest analysis. Moreover, there were significant differences in walking heart rate (bt/min) (η2 = 0.155), heart rate at the end of the test (bt/min) (η2 = 0.093), total time of fitness index test (min) (η2 = 0.097), fitness index (η2 = 0.130), and VO2max (η2 = 0.111) (all, p < 0.001) between control, NW, and RW groups in the posttest analysis. (4) Conclusions: NW group training resulted in slightly greater benefits than RW group training. The present study demonstrated that both groups could act as modalities to improve the functionality and quality of life of people during the ageing process, reflected mainly in HR variables; UKK test measurements, and VO2max. It also contributes to the extant research on older women during exercise and opens interesting avenues for future research.
A STATICAL MODEL OF PLANT FORM-FURTHER ANALYSIS OF THE PIPE MODEL THEORY

OoHATA Sei-ichi (Kyoto Univ. For. Agr., Kyoto Univ., Kyoto) & SHr}gozAKi Kichiro (Sci. Educ. inst. Sakai City, Sakai). 1979. A statical model of plant foTm-Further analysis of the Pipe Model Theory. Jap. J. Ecol. , 29:323-335. in the present study, the structure ofstems in plant communities was analyzed as an extension of the Pipe Model Theory proposed by SHiNozAKi et aL (1964). A close correlation was found between the
Cardiorenal Syndrome: An Updated Classification Based on Clinical Hallmarks

Cardiorenal syndrome (CRS) is defined as progressive, combined cardiac and renal dysfunction. In this mini review, a historical note on CRS is presented, the pathomechanisms and clinical hallmarks of both chronic heart failure and chronic kidney disease are discussed, and an updated classification of CRS is proposed. The current consensus classification relies on the assumed etiology and the course of the disease, i.e., acute or chronic CRS. Five types are described: type-I CRS presenting as acute cardiac failure leading to acute renal failure; type-II CRS presenting as chronic cardiac failure leading to chronic renal failure; type-III CRS presenting as acute kidney injury aggravating heart failure; type-IV CRS presenting as chronic kidney failure aggravating heart failure; and type-V CRS presenting as concurrent, chronic cardiac and renal failure. For an updated classification, information on the presence or absence of valvular heart disease and on the presence of hyper- or hypovolemia is added. Thus, CRS is specified as “acute” (type-I, type-III or type-V CRS) or “chronic” (type-II, type-IV or type-V) CRS, as “valvular” or “nonvalvular” CRS, and as “hyper-” or “hypovolemia-associated” CRS if euvolemia is absent. To enable the use of this updated classification, validation studies are mandated.
3D shape measurement system developed on mobile platform

Three-dimensional (3-D) shape measurement technology based on structured light has become one hot research field inspired by the increasing requirements. Many methods have been implemented and applied in the industry applications, but most of their equipments are large and complex, cannot be portable. Meanwhile, the popularity of the smart mobile terminals, such as smart phones, provides a platform for the miniaturization and portability of this technology. The measurement system based on phase-shift algorithm and Gray-code pattern under the Android platform on a mobile phone is mainly studied and developed, and it has been encapsulated into a mobile phone application in order to reconstruct 3-D shape data in the employed smart phone easily and quickly. The experimental results of two measured object are given in this paper and demonstrate the application we developed in the mobile platform is effective.
Never Cared for What They Do: High Structural Stability of Guanine-Quadruplexes in the Presence of Strand-Break Damage

DNA integrity is an important factor that assures genome stability and, more generally, the viability of cells and organisms. In the presence of DNA damage, the normal cell cycle is perturbed when cells activate their repair processes. Although efficient, the repair system is not always able to ensure complete restoration of gene integrity. In these cases, mutations not only may occur, but the accumulation of lesions can either lead to carcinogenesis or reach a threshold that induces apoptosis and programmed cell death. Among the different types of DNA lesions, strand breaks produced by ionizing radiation are the most toxic due to the inherent difficultly of repair, which may lead to genomic instability. In this article we show, by using classical molecular simulation techniques, that compared to canonical double-helical B-DNA, guanine-quadruplex (G4) arrangements show remarkable structural stability, even in the presence of two strand breaks. Since G4-DNA is recognized for its regulatory roles in cell senescence and gene expression, including oncogenes, this stability may be related to an evolutionary cellular response aimed at minimizing the effects of ionizing radiation.
Crosstalk between Ca2+ and Other Regulators Assists Plants in Responding to Abiotic Stress

Plants have evolved many strategies for adaptation to extreme environments. Ca2+, acting as an important secondary messenger in plant cells, is a signaling molecule involved in plants’ response and adaptation to external stress. In plant cells, almost all kinds of abiotic stresses are able to raise cytosolic Ca2+ levels, and the spatiotemporal distribution of this molecule in distant cells suggests that Ca2+ may be a universal signal regulating different kinds of abiotic stress. Ca2+ is used to sense and transduce various stress signals through its downstream calcium-binding proteins, thereby inducing a series of biochemical reactions to adapt to or resist various stresses. This review summarizes the roles and molecular mechanisms of cytosolic Ca2+ in response to abiotic stresses such as drought, high salinity, ultraviolet light, heavy metals, waterlogging, extreme temperature and wounding. Furthermore, we focused on the crosstalk between Ca2+ and other signaling molecules in plants suffering from extreme environmental stress.
A tracking microwave wideband band reject filter using antiphase locking

ABSTRACT This paper reports implementation of a wideband microwave band reject filter (BRF) at a centre frequency of 10 GHz which is based on a new principle of out of phase locking of a pair of Gunn oscillators by a reflected signal. The measured 3-dB bandwidth of the BRF is 486 MHz which is 4.86% of the centre frequency of the BRF with a rejection ratio of 7.08 dB. The bandwidth lies in between narrow band and ultrawide band domain.
A Prospective Analysis of the Simplified Student Sight Savers Program on Open-Angle Glaucoma Cost Burden in Underserved Communities

(1) Background: Glaucoma is a leading cause of irreversible blindness worldwide. Unfortunately, no noticeable symptoms exist until mid- to late-stage glaucoma, leading to substantial costs to the patient and the healthcare system. (2) Methods: The Student Sight Savers Program, an initiative started at Johns Hopkins University, was designed to meet the needs of community screening for glaucoma. Several medical students at the Rocky Vista University in Saint George, Utah, were trained, and screened patients at local fairs and gathering places using a modified version of this program. Patients found to have elevated pressure (>21 mmHg) or other ocular abnormalities were referred for an ophthalmological examination. (3) Results: Individuals from medically underserved areas/populations (MUA/Ps) were nearly three times as likely to have elevated intraocular pressure as individuals not in underserved areas (p = 0.0141). A further analysis demonstrates that medical students can help reduce medical costs for patients and the healthcare system by providing referrals to ophthalmologists and reaching populations that are not usually screened for glaucoma. (4) Conclusions: Allowing medical students to perform community-based glaucoma screening events in MUA/Ps using handheld tonometers may decrease the cost burden associated with late diagnosis, and raise awareness about glaucoma, especially in underserved populations.
Physical Activity and Food Environments in and around Schools: A Case Study in Regional North-West Tasmania

A better understanding of the physical activity (PA) infrastructure in schools, the walkability of neighborhoods close to schools, and the food environments around schools, particularly in rural, socioeconomically challenged areas such as the North-West (NW) of Tasmania, could be important in the wider effort to improve the health of school-age children. Accordingly, this research aimed to assess PA resources, walkability, and food environments in and around schools in three socioeconomically disadvantaged, regional/rural Local Government Areas (LGAs) of Tasmania, Australia. A census of schools (including assessment of the PA infrastructure quality within school grounds), a walkability assessment, and a census of food outlets surrounding schools (through geospatial mapping) were executed. Most of the schools in the study region had access to an oval, basketball/volleyball/netball court, and free-standing exercise equipment. In all instances (i.e., regardless of school type), the quality of the available infrastructure was substantially higher than the number of incivilities observed. Most schools also had good (i.e., within the first four deciles) walkability. Numerous food outlets were within the walking zones of all schools in the study region, with an abundance of food outlets that predominantly sold processed unhealthy food.
Isolation of endophytic bacteria from wild plants in dry regions and investigation of their ability to promote plant growth and inhibit pathogenic fungi

In the dry regions environments such as Saudi Arabia, bacterial endophytes isolated from the roots and soil of healthy wild plants can promote plant growth by developing siderophores, phosphate solubilizing, Indole 3 Acetic Acid (IAA), and inhibit the growth of some plant fungal pathogens. This study aimed to isolate bacteria from wild plants in dry regions and to investigate their ability to be used as plant growth-promoting agent and inhibit plant pathogenic fungi. More than ninety endophytic bacterial isolates associated with the leaves, roots, and soil of healthy wild plants were collected from different sites in the Qassim region, Kingdom of Saudi Arabia, with the aim of characterizing and testing for their ability to promote plant growth activities and inhibit plant pathogenic fungi. Seventy strains were shown to produce indole-3-acetic acid (IAA) and 45 isolates produced siderophores, with 16 of these exhibiting large amounts. Twelve isolates tested positive for phosphate solubilization, with two isolates (QUSA 66 and QUSA 91) exhibiting greater efficiency for phosphate solubility. Twenty-five isolates produced more than 100 µg mL-1 of IAA, with production ranging from 100.5 to 404.7 µg mL-1. Six of these bacterial isolates (QUSA 2, 7, 10, 29, 30. and 40) produced more than 200 µg mL-1. A wide spectrum of activities was noted within the pseudomonas strains, indicating promising plant growth-promoting potential (e.g., the isolates from Pulicaria crispa and Calligonum comosum). In vitro results against plant pathogenic fungi showed that fifteen of the bacterial isolates inhibited growth of fungal mycelia by producing wide antagonistic zones. The isolates QUSA 26, 27, 28, 36, and 87 were able to produce siderophores and IAA and to solubilize phosphate. In addition, these isolates delayed mycelium growth of some Fusarium, Rhizoctonia solani, Botrytis, and Stemphylium spp
Pengaruh Corporate Social Responsibility Terhadap Kinerja Perusahaan pada PT. PLN UP3 Baubau

This paper intent to know influence corporate social responsibility to corporate performance on PT. PLN UP3 Baubau. The main purpose of business activities is not only to obtain optimal profits but business activities also have social obligations. Corporate Social Responsibility (CSR) is a form of social obligation undertaken by company or business. Data collecting is done by use of questioner. Acquired data of 30 persons. Analysis is data utilizes simple linear regression. The Result of this research indicated that Y = 5.833 + 0.686 x It points out that if happening changing dimension carries the ball firm social as big as 1, therefore will cause changing to performance as big as 68,6 %, carries the ball influential firm socials to performances can be seen of significant point t on analysis simple regression which is sig t = 0,00< a = 0,05. Correlation coefficient point (R) as big as 0,809 used to mean that correlation relationship among variable free corporate social accountability (X) to performances (Y) is positive.
Effects of Bacillus cereus on Photosynthesis and Antioxidant Metabolism of Cucumber Seedlings under Salt Stress

Soil salinization is the leading environmental factor that restricts crop growth. This study studied the effects of Bacillus cereus (B. cereus) on growth, photosynthesis, and antioxidant metabolism in salt stressed-cucumber seedlings. The results showed that B. cereus could maintain high activity in the high salt environment (4% NaCl). B. cereus significantly increased plant height, stem diameter, fresh weight, and dry weight of cucumber seedlings under salt stress, and increased root vitality, net photosynthetic rate (Pn), stomatal conductance (Gs), intercellular CO2 concentration (Ci), and transpiration rate (Tr) of cucumber seedlings under salt stress. B. cereus significantly increased the maximum photochemical quantum yield of photosystem II (Fv/Fm), the actual photochemical quantum yield (ΦPSII), and the quantum yield of regulatory energy dissipation Y (NPQ) under salt stress, which were 9.31%, 20.44%, and 5.22% higher than those under salt stress, respectively. The quantum yield of non-regulatory energy dissipation Y (NO) was reduced by 19.81%. Superoxidase (SOD), peroxidase (POD), and catalase (CAT) activities in leaves and roots of cucumber seedlings were significantly increased by B. cereus under salt stress. Compared with salt stress, SOD activities in leaves were significantly increased by 1.70% and 6.32% on the first and third days after treatment. At 1 d, 3 d, and 5 d after treatment, SOD activity in roots increased by 3.06%, 11.24%, and 3.00%, POD activity in leaves increased by 113.38%, 38.81%, and 52.89%, respectively. The POD activity in roots increased by 56.79% and 10.92% on the third and fifth days after treatment, the CAT activity in leaves increased by 8.50% and 25.55%, and the CAT activity in roots increased by 30.59% and 84.45%. Under salt stress, the H2O2 and MDA contents of seedlings treated with B. cereus decreased significantly. Compared with salt stress, the proline content in leaves decreased by 12.69%, 3.90%, and 13.12% at 1 d, 3 d, and 5 d, respectively, while the proline content in roots decreased by 44.94% and 60.08% at 3 d and 5 d, respectively. These results indicated that B. cereus could alleviate salt-induced inhibition of growth and photosynthesis by regulating antioxidant metabolism of cucumber seedlings and thus enhancing salt tolerance of cucumber seedlings.