Miracle-dz/UniFAR-FTUs huggingface dataset:
Addressing Public Speaking Anxiety in Multicultural Counselling: The Use of Cognitive-Behavioural Therapy for International Students

Abstract: Several studies have highlighted the importance of Cognitive Behavioural Therapy (CBT) in reducing public speaking anxiety. The studies also denote the increase of confidence by strengthening self-efficacy. This study explores previous studies that uncover the use of CBT in dealing with public anxiety to identify its potential as part of multicultural counseling for international students in higher education. International students have different academic and learning cultures, as well as social environments, affecting the development of certain anxiety in dealing with pressures to adapt to new environments. Therefore, it positions the investigation of CBT’s ability to reduce public speaking anxiety for international students as highly essential. This study contends that CBT is a useful technique to unpack irrational fear of speaking in public and promote self-efficacy, developing confidence and leading to good mental health. However, given the nature of targeted intervention are international students, multicultural counseling competencies are undoubtedly required for the therapy. Abstrak: Beberapa penelitian telah menyoroti pentingnya Terapi Perilaku Kognitif (CBT) dalam mengurangi kecemasan berbicara di depan umum. Studi ini menunjukkan adanya peningkatan kepercayaan diri dengan memperkuat efikasi diri. Studi ini juga mengeksplorasi studi sebelumnya yang mengungkap penggunaan CBT dalam menangani kecemasan publik untuk mengidentifikasi potensinya sebagai bagian dari konseling multikultural untuk mahasiswa internasional di pendidikan tinggi. Mahasiswa internasional memiliki budaya akademik, pembelajaran, dan lingkungan sosial yang berbeda, yang semuanya memengaruhi perkembangan kecemasan tertentu dalam menghadapi tekanan untuk beradaptasi dengan lingkungan baru. Oleh karena itu, penelitian tentang CBT untuk mengurangi kecemasan berbicara di depan umum bagi mahasiswa internasional sangat penting. Studi ini berpendapat bahwa CBT adalah teknik yang berguna untuk membongkar ketakutan irasional berbicara di depan umum dan mempromosikan efikasi diri, mengembangkan kepercayaan diri dan mengarahkan kesehatan mental yang baik. Namun, mengingat sifat intervensi yang ditargetkan adalah siswa internasional, kompetensi konseling multikultural tidak diragukan lagi diperlukan dalam terapi.
VIP/VPAC Axis Expression in Immune-Mediated Inflammatory Disorders: Associated miRNA Signatures

Few studies have considered immune-mediated inflammatory disorders (IMID) together, which is necessary to adequately understand them given they share common mechanisms. Our goal was to investigate the expression of vasoactive intestinal peptide (VIP) and its receptors VPAC1 and VPAC2 in selected IMID, analyze the effect of biological therapies on them, and identify miRNA signatures associated with their expression. Serum VIP levels and mRNA of VPAC and miRNA expression in peripheral blood mononuclear cells were analyzed from 52 patients with psoriasis, rheumatoid arthritis, Graves’ disease, or spondyloarthritis and from 38 healthy subjects. IMID patients showed higher levels of VIP and increased expression of VPAC2 compared to controls (p < 0.0001 and p < 0.0192, respectively). Receiver operating characteristic curve analysis showed that the levels of VIP or VPAC2 expression were adequate discriminators capable of identifying IMID. Treatment of IMID patients with anti-TNFα and anti-IL12/23 significantly affected serum VIP levels. We identified miRNA signatures associated with levels of serum VIP and VPAC2 expression, which correlated with IMID diagnosis of the patients. The results indicate that the expression of VIP/VPAC2 is able of identify IMIDs and open up a line of research based on the association between the VIP/VPAC axis and miRNA signatures in immune-mediated diseases.
MALDI mass spectrometric imaging methods for localization and identification of pathophysiological relevant regulators in tissue samples

• A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers.
Potential modifiable factors associated with late-life cognitive trajectories

Objective There is variability across individuals in cognitive aging. To investigate the associations of several modifiable factors with high and low cognitive performance. Methods Data came from 17,724 community-dwelling individuals aged 65–98 years. Global cognition, verbal fluency, episodic memory, and psychomotor speed were assessed over up to seven years. Group-based multi-trajectory modeling identified distinct cognitive trajectories. Structural equation modeling examined the direct/indirect associations of social/behavioral factors and several chronic conditions with cognitive trajectories. Results Seven trajectory subgroups were identified. In the structural equation modeling we compared two subgroups-participants with the highest (14.2%) and lowest (4.1%) cognitive performance with the average subgroup. Lower education, never alcohol intake, and frailty directly predicted increased risk of low performance, and decreased likelihood of high performance. Hypertension (RR: 0.69, 95%CI: 0.60–0.80), obesity (RR: 0.84, 95%CI: 0.73–0.97), diabetes (RR: 0.69, 95%CI: 0.56–0.86) and depression (RR: 0.68, 95%CI: 0.54–0.85) only predicted lower likelihood of high cognitive performance, while dyslipidemia was only associated with low performance (RR: 1.30, 95%CI: 1.07–1.57). Living alone predicted increased risk of low cognitive performance and several comorbidities. Smoking did not predict cognitive trajectories but was associated with increased risk of diabetes, obesity and frailty. Findings were similar when examining the direct associations between modifiable risk factors and all seven cognitive subgroups. Conclusions Although several modifiable factors were associated with high performance, and reversely with low performance, this was not observed for obesity, hypertension and dyslipidemia. Further, health behaviors may affect cognitive function indirectly, via geriatric conditions. This indicates that strategies to promote healthy cognitive aging, may be distinct from those targeting dementia prevention.
Fn-Dps, a novel virulence factor of Fusobacterium nucleatum, disrupts erythrocytes and promotes metastasis in colorectal cancer

Fusobacterium nucleatum (Fn) is a critical colorectal cancer (CRC)-associated bacterium. DNA hunger/stationary phase protective proteins (Dps) are bacterial ferritins that protect DNA from oxidative stress. However, little is known about the regulatory roles of Fn-Dps towards host cellular functions. Here, we identified Fn-Dps from the culture supernatant of Fn by mass spectrometry, and prepared the recombinant of Fn-Dps protein. We show a novel virulence protein of Fn, Fn-Dps, which lyses and disrupts erythrocytes by the competition for iron acquisition. Also, Fn-Dps facilitates intracellular survival of Fn in macrophages by upregulating the expression of the chemokine CCL2/CCL7. In addition, Fn-Dps can elicit a strong humoral immune response, and mucosal immunization with Fn-Dps conferred protection against Fn in the intestinal tract. Moreover, a high level of anti-Fn-Dps antibody was prevalent in populations, and elevated anti-Fn-Dps antibody levels were observed in CRC patients. Furthermore, Fn-Dps promotes the migration of CRC cells via the CCL2/CCL7-induced epithelial-mesenchymal transition (EMT) and promotes CRC metastasis in vivo.
Investigating the Sensitivity of a Land Surface Scheme's Simulation of Soil Wetness and Evaporation

A suite of sensitivity experiments focusing on leaf area index (LAI) was conducted within the GSWP framework using one land surface scheme. First, the LAI was changed from the original 1x1 resolution provided by GSWP so that it was determined by vegetation type. This was then varied by plus and minus one standard deviation. Additional experiments explored sensitivity to the global use of a single LAI value, to aggregation of LAI to coarser resolution, and to changes in the seasonal variation in LAT. Results showed a sensitivity to LAI such that changes in total evaporation of 30W m-2 (July average) were common. Changes in soil wetness occurred which commonly exceeded 5%, and sometimes exceeded 10%, of the soil moisture at saturation. These changes in soil wetness are large enough to suggest that LAI needs to be provided with care within GSWP, and that any soil wetness product requires LAI to be provided with reasonable accuracy (perhaps within +1 and certainly within +2). Any problems in the LAI data (particularly in the magnitude rather than the precise seasonal variation) will lead to errors in the simulation of a soil wetness product.
Effect of Image Detection and Analysis and Hospice Nurse Mediated Aromatherapy on Pain in Patients with Advanced Cancer in Intelligent Medical Environment

Objective In order to better alleviate the pain symptoms of patients with advanced cancer, this study adopts image detection and analysis and hospice nurse mediated aromatherapy, so as to comprehensively understand the physical condition of patients with advanced cancer and finally implement the nursing scheme of aromatherapy. Methods Sixty advanced cancer patients admitted to a tertiary and grade A oncology hospital in Jiangxi Province from December 2020 to March 2022 were selected. This study was randomized into trial and control groups. The control group contained 30 regular treatment patients and 30 regular nursing patients for advanced cancer patients, and the trial group performed a 28-day hospice care specialist nurse-mediated aromatherapy based on the control group. Pain and quality of life scores were measured before and after the intervention in both groups. The experimental group consisted of 30 cases, with the mean age of 58.2 years; the control group consisted of 30 cases, with the mean age of 58.6 years. Results 60 patients with advanced cancer were selected for group comparison. The results showed that the effect of aromatherapy mediated by hospice nurse on pain score, QLQ-C30, index value of patients with advanced cancer (the experimental group) was better than that of patients with advanced cancer (the control group). Conclusion Through retrospective analysis, we investigated the patients with advanced cancer and discussed the difference between conventional therapy and aromatherapy. The results showed that aromatherapy based on image detection and analysis and mediated by Anning nurses was helpful to alleviate the physical function of patients with advanced cancer and improve their quality of life, which provided a reference for clinical application.
Leaf area estimation of Congea tomentosa using a non-destructive method

ABSTRACT Congea tomentosa is a climbing plant suitable for covering arbors, railings, and fences. Leaf area determination is useful in understanding the plant-environment relationship and facilitating agronomic studies on transpiration, water requirement, light interception, and photosynthetic activity. The objective of this study was to obtain an allometric equation to estimate the leaf area of C. tomentosa by measuring the leaf dimensions. Analyses were performed on 200 leaves of different shapes and sizes from 10 randomly chosen adult plants grown under field conditions. The leaf length, leaf width, product length and width, and leaf area were determined. Linear, linear without intercept, quadratic, cubic, power, and exponential regression models were used to estimate the leaf area. The coefficient of determination, Willmott’s concordance index, Akaike information criterion, root mean square error and BIAS index were used to determine the best model. The leaf area of C. tomentosa can be satisfactorily estimated using a non-destructive method that uses measurements of leaf dimensions. The equation ŷ = 0.63 × LW (Leaf: L = length, W = width) estimates the leaf area of C. tomentosa in a practical and fast way, with 99.15% of precision. Estimation of the leaf area of C. tomentosa using statistical models is less expensive and easily accessible to researchers and producers of this plant.
MODEL FOR THE SIMULATION OF THE INTERFACE DISPERSION

The complexity of two-fluid flow is reflected on the various types of the interface shape between fluids. A specific numerical model might have good characteristic for a particular type of the two fluid flow, but might be completely useless for any other. There is number of physical phenomena, where during the transient a significant topological change of the interface reflects the change of the two-fluid flow type. An example is dispersion of the stratified fluids into the bubbly flow die to the Rayleigh-Taylor or Kelvin-Helmholtz instabilities. Such phenomena cannot be simulated accurately with the single model.
The Epidemiology of Bovine Viral Diarrhea Virus in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis

Introduction Bovine viral diarrhea virus (BVDV) causes reproductive inefficiencies and negatively impacts the economy of low- and middle-income countries (LMICs). It is characterized by a combination of syndromes that result in poor production performance and calf morbidity and mortality. BVDV control is possible by introduction of biosecurity measures, test-and-cull, and vaccination programs as accomplished in high-income countries. Knowledge of BVDV epidemiology is limited in many LMICs, which hinders implementation of effective control programs. We carried out a systematic review and meta-analysis to estimate the burden of BVDV, identify risk factors related to its occurrence, and health and economic impacts on production systems. Materials and Methods Relevant BVD articles were collated from library databases; 690 abstracts and full texts were found in an initial search followed by filtering of 59 manuscripts. We accounted for quality and risk of bias in the meta-analysis. Prevalence, exposure, and current infection at regional, production, and farming system levels were estimated using logistic random-effects meta-regression models. Finally, we calculated the proportion of studies that addressed risk factors and health and economic impacts across different production systems to inform future preventative strategies in LMICs. Results Seroprevalence was high and varied between regions. Mean weighted prevalence was 39.5% (95% CI 25–56.1), 45.2% (95% CI 35.9–54.8), 49.9% (95% CI 25.5–74.3), and 21.6% (95% CI 0.5–56) for sub-Saharan Africa, South America, Middle East, and Asia, respectively. Seroprevalence varied across farming systems, with smallholder farming showing the highest values. Herdsize was the most frequently reported risk factor, and the percentage of articles that reported herdsize as a risk factor were 20.6%, 33.3%, and 38.4% for dairy, beef and mixed systems respectively. Abortion (13.7% of articles) was the main reported health impact in dairy systems. Some articles reported milk drop (4.6% of articles), but no article investigated the economic cost of BVDV in farming systems. Conclusion Animal-level seroprevalence varied across all regions. Most of the studies focused on BVDV seroprevalence. There were some articles that investigated risk factors and health impacts, and there were even less that investigated economic impacts. Future studies should focus on identifying risk factors and quantifying health and economic impacts across systems. Understanding these aspects is crucial to develop management strategies to apply across diverse production systems in LMICs.
Combining Long-Term Recurrent Convolutional and Graph Convolutional Networks to Detect Phishing Sites Using URL and HTML

Phishing, a well-known cyber-attack practice has gained significant research attention in the cyber-security domain for the last two decades due to its dynamic attacking strategies. Although different solutions have been exercised against phishing, phishing attacks have dramatically increased in the past few years. Recent studies have shown that machine learning has become prominent in the present anti-phishing context, and the techniques like deep learning have extensively improved anti-phishing tools’ detection ability. This paper proposes PhishDet, a new way of detecting phishing websites through Long-term Recurrent Convolutional Network and Graph Convolutional Network using URL and HTML features. PhishDet is the first of its kind, which uses the powerful analysis and processing capabilities of Graph Neural Network in the anti-phishing domain and recorded 96.42% detection accuracy, with a 0.036 false-negative rate. It is effective against zero-day attacks, and the average detection time which is 1.8 seconds could also be considered realistic. The feature selection of PhishDet is automatic and occurs inside the system, as PhishDet gradually learns URLs and HTML content features to handle constantly changing phishing attacks. This has outperformed similar solutions by achieving a 99.53% f1-score with a public benchmark dataset. However, PhishDet requires periodic retraining to maintain its performance over time. If such retraining could be facilitated, PhishDet could fight against phishers for a more extended period to safeguard Internet users from this Internet threat.
Material Design for Next-Generation mRNA Vaccines Using Lipid Nanoparticles

Abstract Vaccine development is among the critical issues for ceasing the COVID-19 pandemic. This review discusses the current usage of biomaterials in vaccine development and provides brief descriptions of the vaccine types and their working mechanisms. New types of vaccine platforms (next-generation vaccines and DNA- or mRNA-based vaccines) are discussed in detail. The mRNA vaccine encoding the spike protein viral antigen can be produced in a cell-free system, suggesting that mRNA vaccines are safer than “classic vaccines” using live or inactivated virus. The mRNA vaccine efficacy is typically high at approximately 95%. However, most mRNA vaccines need to be maintained at −20 or −70 degrees for storage for long periods (half a year) and their transportation because of mRNA vaccine instability in general, although mRNA vaccines with unmodified and self-amplifying RNA (ARCT-154, Arcturus), which have a lyophilized form, have recently been reported to be kept at room temperature. mRNA vaccines are typically entrapped in lipid nanoparticles composed of ionizable lipids, polyethylene glycol (PEG)-lipids, phospholipids, and cholesterol. These components and their composition affect mRNA vaccine stability and efficacy and the size of the mRNA vaccine. The development of an improved mRNA vaccine entrapped in sophisticated biomaterials, such as novel lipid nanoparticles, using new types of biopolymers or lipids is necessary for high efficacy, safe transportation and long-term storage of the next generation of mRNA vaccines under mild conditions.
Strategi Komunikasi Pembangunan dalam Difusi Teknologi Pengolahan Limbah Air (Studi Kasus IPAL Dusun Giriharja dan Biotoilet SDN Babakan Sinyar)

Air limbah memiliki potensi besar untuk menjadi sumber daya berharga bagi masyarakat. Baik di negara maju maupun berkembang, isu mengenai daur ulang air limbah senantiasa menjadi topik yang penting. Hal ini karena air limbah memiliki berbagai kandungan zat yang jika diolah dengan baik dapat bermanifestasi dalam berbagai manfaat seperti mengurangi pencemaran lingkungan, pupuk organik, hingga sumber energi terbarukan. Penelitian ini bertujuan untuk menguraikan bagaimana strategi komunikasi pembangunan Pusat Riset Lingkungan dan Teknologi Bersih (PRLTB BRIN) dalam upaya difusi teknologi pengolahan air limbah di Kecamatan Sumedang Utara dan Kecamatan Kiaracondong, Jawa Barat. PRLTB BRIN bekerja sama dengan berbagai pihak membangun reaktor biogas dan toilet pengompos sebagai bentuk implementasi kajian ilmiahnya di bidang teknologi bersih. Riset ini menggunakan paradigma konstruktivis dengan desain studi multikasus. Wawancara mendalam, studi literatur, dan observasi dilakukan untuk menganalisis bagaimana strategi komunikasi dan tahapan difusi inovasi berlangsung. Hasil riset menunjukan difusi inovasi teknologi IPAL Biogas berlangsung dengan baik hingga tahap konfirmasi. Strategi partisipatori dengan saluran komunikasi interpersonal menjadi landasan utama implementasi teknologi IPAL Biogas. Strategi desain instruksional dengan komunikasi interpersonal mengokohkan uji coba toilet pengompos di SDN 210 Babakan Sinyar. Tahapan difusi inovasi toilet pengompos di SDN 210 Babakan Sinyar masih berada pada tingkat keputusan.
Hilbert''''s theorem on positive ternary quartics

An optical coupler transfers light energy signals relative to an optical path which includes a fiber optic cable. A body member includes first and second ports at opposite ends for supporting first and second terminals of the fiber optic cable in laterally offset alignment relative to each other. First and second reflective elements, preferably of concave spherical configuration, are supported within the body member for collecting and reflecting light energy transmitted through the first and second terminals of the fiber optic cable. The first and second reflective elements are so configured and positioned as to transmit collimated light energy between them for completing the optical path between the first and second terminals of the fiber optic cable. First and second planar reflective surfaces are supported from opposite sides of the body member to intercept a portion of the path of the collimated light energy and are angularly disposed to laterally transfer light energy relative to the optical path between the first and second reflective elements. Preferably, the planar reflector surfaces are removable so as to minimize interference with light energy signal transmission between the collimating reflective elements and reduce attenuation. Additionally, the planar reflector surface may desirably be frequency sensitive so as to extract from or introduce into the optical path only certain selected frequencies of light energy signals.