Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynein localization and pronuclear movement in the C. elegans zygote

Centrosomes serve as a site for microtubule nucleation and these microtubules will grow and interact with the motor protein dynein at the cortex. The position of the centrosomes determines where the mitotic spindle will develop across all cell types. Centrosome positioning is achieved through dynein and microtubule‐mediated force generation. The mechanism and regulation of force generation during centrosome positioning are not fully understood. Centrosome and pronuclear movement in the first cell cycle of the Caenorhabditis elegans early embryo undergoes both centration and rotation prior to cell division. The proteins LET‐99 and GPB‐1 have been postulated to have a role in force generation associated with pronuclear centration and rotation dynamics. When the expression of these proteins is perturbed, pronuclear positioning exhibits a movement defect characterized by oscillatory (“wobble”) behavior of the pronuclear complex (PNC). To determine if this movement defect is due to an effect on cortical dynein distribution, we utilize RNAi‐mediated knockdown of LET‐99 and GPB‐1 to induce wobble and assay for any effects on GFP‐tagged dynein localization in the early C. elegans embryo. To compare and quantify the movement defect produced by the knockdown of LET‐99 and GPB‐1, we devised a quantification method that measures the strength of wobble (“wobble metric”) observed under these experimental conditions. Our quantification of pronuclear complex dynamics and dynein localization shows that loss of LET‐99 and GPB‐1 induces a similar movement defect which is independent of cortical dynein localization in the early C. elegans embryo.
Dark Sky Simulations: Early Data Release

The Dark Sky Simulations are an ongoing series of cosmological N-body simulations designed to provide a quantitative and accessible model of the evolution of the large-scale Universe. Such models are essential for many aspects of the study of dark matter and dark energy, since we lack a sufficiently accurate analytic model of non-linear gravitational clustering. In July 2014, we made available to the general community our early data release, consisting of over 55 Terabytes of simulation data products, including our largest simulation to date, which used $1.07 \times 10^{12}~(10240^3)$ particles in a volume $8h^{-1}\mathrm{Gpc}$ across. Our simulations were performed with 2HOT, a purely tree-based adaptive N-body method, running on 200,000 processors of the Titan supercomputer, with data analysis enabled by yt. We provide an overview of the derived halo catalogs, mass function, power spectra and light cone data. We show self-consistency in the mass function and mass power spectrum at the 1% level over a range of more than 1000 in particle mass. We also present a novel method to distribute and access very large datasets, based on an abstraction of the World Wide Web (WWW) as a file system, remote memory-mapped file access semantics, and a space-filling curve index. This method has been implemented for our data release, and provides a means to not only query stored results such as halo catalogs, but also to design and deploy new analysis techniques on large distributed datasets.
Magnetic hysteresis effects in superconducting coplanar microwave resonators

Institut fu¨r Mikro- und Nanoelektronische Systeme,Karlsruher Institut fu¨r Technologie, Hertzstrasse 16, 76187 Karlsruhe, Germany(Dated: February 28, 2012)We performed transmission spectroscopy experiments on coplanar half wavelength niobium res-onators at a temperature T = 4.2K. We observe not only a strong dependence of the quality factorQ and the resonance frequency f
Measurement and reporting of footwear characteristics in running biomechanics: A systematic search and narrative synthesis of contemporary research methods

ABSTRACT This review aimed to synthesise the methods for assessing and reporting footwear characteristics among studies evaluating the effect of footwear on running biomechanics. Electronic searches of Scopus®, EBSCO, PubMed®, ScienceDirect®, and Web of Science® were performed to identify original research articles of the effect of running footwear on running biomechanics published from 1st January 2015 to 7th October 2020. Risk of bias among included studies was not assessed. Results were presented via narrative synthesis. Eligible studies compared the effect of two or more footwear conditions in adult runners on a biomechanical parameter. Eighty-seven articles were included and data from 242 individual footwear were extracted. Predominantly, studies reported footwear taxonomy (i.e., classification) and manufacturer information, however omitted detail regarding the technical specifications of running footwear and did not use validated footwear reporting tools. There is inconsistency among contemporary studies in the methods by which footwear characteristics are assessed and reported. These findings point towards a need for consensus regarding the reporting of these characteristics within biomechanical studies to facilitate the conduct of systematic reviews and meta-analyses pertaining to the effect of running footwear on running biomechanics.
Tracking vocabulary and reading growth in children from lower and higher socioeconomic backgrounds during the transition from primary to secondary education

Abstract We examined the relation between socioeconomic status (SES), vocabulary, and reading in middle childhood, during the transition from primary (elementary) to secondary (high) school. Children (N = 279, 163 girls) completed assessments of everyday and curriculum‐related vocabulary, (non)word reading, and reading comprehension at five timepoints from age 10 to 13. Piecewise linear mixed‐effects models showed significant growth in everyday vocabulary and word reading between every time point. Curriculum vocabulary and reading comprehension showed significant growth during the school year, but not during the summer holidays. There were significant effects of SES on all measures except word reading; yet, SES differences did not widen over time. Our findings motivate targeted reading and vocabulary support for secondary school students from lower SES backgrounds.
Maxwell's demons in multipartite quantum correlated systems

We investigate the extraction of thermodynamic work by a Maxwell's demon in a multipartite quantum correlated system. We begin by adopting the standard model of a Maxwell's demon as a Turing machine, either in a classical or quantum setup depending on its ability of implementing classical or quantum conditional dynamics, respectively. Then, for an n-partite system (A_1, A_2, ., A_n), we introduce a protocol of work extraction that bounds the advantage of the quantum demon over its classical counterpart through the amount of multipartite quantum correlation present in the system, as measured by a thermal version of the global quantum discord. This result is illustrated for an arbitrary n-partite pure state of qubits with Schmidt decomposition, where it is shown that the thermal global quantum discord exactly quantifies the quantum advantage. Moreover, we also consider the work extraction via mixed multipartite states, where examples of tight upper bounds can be obtained.
Reconsidered surgical aortic valve replacement after declined transcatheter valve implantation

Background Outcomes for high surgical risk patients who declined transcatheter aortic valve implantation (TAVI) and then reconsidered for conventional aortic valve replacement (rSAVR) for severe calcific aortic stenosis are not well known. Methods This single-centre, case–control study (rSAVR vs Conservative group) retrospectively analysed patients for rSAVR (2009–2019). Multivariable logistic regression was used to identify independent predictors of composite of neurological sequelae/renal failure/deep sternal wound infection/re-exploration and death. Survival was compared using Kaplan–Meier curves and log-rank test. A Cox proportional hazards model was used to determine predictors of survival. Results TAVI was denied in 519/1095 patients, 114(10.4%) had rSAVR (cases) and 405 (37%) were managed conservatively (controls). Mean age for rSAVR was 80 years (IQR: 73.5–85 years). The commonest reason for declining TAVI was prohibitive high risk due to multiple comorbidities. Among rSAVR, hospital mortality was 2.2% and stroke was 4.4%. Median follow-up was conservative; 14.4 months versus rSAVR; 34.8 months. Five-year survival was conservative; 12.6% versus rSAVR; and 59.5% (overall conservative; 38.0% vs. rSAVR; 60.5%, p < 0.001). rSAVR was protective (hazard ratio [HR]: 0.37, 95% confidence interval [CI]: 0.26, 0.51, p < 0.001) and high comorbidities had high hazard (HR: 1.57, 95% CI: 1.19, 2.07, p = 0.001). rSAVR had fewer hospital readmission episodes (Conservative; 13.6/patient-year vs. rSAVR; 6.9/patient-year, p = 0.002). Conclusions rSAVR may be considered in high surgical risk elderly patients who have been declined TAVI in centres with low operative mortality. rSAVR may be superior to conservative management in carefully selected patients.
SLOSHING COLD FRONTS IN GALAXY GROUPS AND THEIR PERTURBING DISK GALAXIES: AN X-RAY, OPTICAL, AND RADIO CASE STUDY

We present a combined X-ray, optical, and radio analysis of the galaxy group IC 1860 using the currently available Chandra and XMM data, multi-object spectroscopy data from the literature, and Giant Metrewave Radio Telescope (GMRT) data. The Chandra and XMM imaging and spectroscopy reveal two surface brightness discontinuities at 45 and 76 kpc shown to be consistent with a pair of cold fronts. These features are interpreted as due to sloshing of the central gas induced by an off-axis minor merger with a perturber. This scenario is further supported by the presence of a peculiar velocity of the central galaxy IC 1860 and the identification of a possible perturber in the optically disturbed spiral galaxy IC 1859. The identification of the perturber is consistent with the comparison with numerical simulations of sloshing. The GMRT observation at 325 MHz shows faint, extended radio emission contained within the inner cold front, as seen in some galaxy clusters hosting diffuse radio mini-halos. However, unlike mini-halos, no particle reacceleration is needed to explain the extended radio emission, which is consistent with aged radio plasma redistributed by the sloshing. There is a strong analogy between the X-ray and optical phenomenology of the IC 1860 group and that of two other groups, NGC 5044 and NGC 5846, showing cold fronts. The evidence presented in this paper is among the strongest supporting the currently favored model of cold-front formation in relaxed objects and establishes the group scale as a chief environment for studying this phenomenon.
Preoperative systemic inflammation response index is an independent prognostic marker for BCG immunotherapy in patients with non‐muscle‐invasive bladder cancer

The Systemic Inflammatory Response Index (SIRI) is a novel prognostic biomarker based on peripheral blood counts of neutrophils, monocytes, and lymphocytes. Recent evidence suggests that it is associated with poor prognosis in various cancers. However, the predictive value of the SIRI in non‐muscle‐invasive bladder cancer (NMIBC) patients treated with intravesical Bacillus Calmette‐Guerin (BCG) immunotherapy remains elusive. Therefore, this study aimed to evaluate the potential of SIRI as a prognostic factor in these patients.
Cost-effective micro-CT system for non-destructive testing of titanium 3D printed medical components

Micro-CT imaging can be used as an effective method for non-destructive testing (NDT) of metal 3D printed parts–including titanium biomedical components fabricated using laser powder-bed-fusion (LPBF). Unfortunately, the cost of commercially available micro-CT scanners renders routine NDT for biomedical applications prohibitively expensive. This study describes the design, manufacturing, and implementation of a cost-effective scanner tailored for NDT of medium-size titanium 3D printed biomedical components. The main elements of the scanner; which include a low-energy (80 kVp) portable x-ray unit, and a low-cost lens-coupled detector; can be acquired with a budget less than $ 11000 USD. The low-cost detector system uses a rare-earth phosphor screen, lens-coupled to a dSLR camera (Nikon D800) in a front-lit tilted configuration. This strategy takes advantage of the improved light-sensitivity of modern full-frame CMOS camera sensors and minimizes source-to-detector distance to maximize x-ray flux. The imaging performance of the system is characterized using a comprehensive CT quality-assurance phantom, and two titanium 3D-printed test specimens. Results show that the cost-effective scanner can survey the porosity and cracks in titanium parts with thicknesses of up to 13 mm of solid metal. Quantitatively, the scanner produced geometrically stable reconstructions, with a voxel size of 118 μm, and noise levels under 55 HU. The cost-effective scanner was able to estimate the porosity of a 17 mm diameter titanium 3D-printed cylindrical lattice structure, with a 0.3% relative error. The proposed scanner will facilitate the implementation of titanium LPBF-printed components for biomedical applications by incorporating routine cost-effective NDT as part of the process control and validation steps of medical-device quality-management systems. By reducing the cost of the x-ray detector and shielding, the scan cost will be commensurate with the overall cost of the validated component.
Finite Volume Methods for Hyperbolic Problems: Characteristics and Riemann Problems for Linear Hyperbolic Equations

Preface 1. Introduction 2. Conservation laws and differential equations 3. Characteristics and Riemann problems for linear hyperbolic equations 4. Finite-volume methods 5. Introduction to the CLAWPACK software 6. High resolution methods 7. Boundary conditions and ghost cells 8. Convergence, accuracy, and stability 9. Variable-coefficient linear equations 10. Other approaches to high resolution 11. Nonlinear scalar conservation laws 12. Finite-volume methods for nonlinear scalar conservation laws 13. Nonlinear systems of conservation laws 14. Gas dynamics and the Euler equations 15. Finite-volume methods for nonlinear systems 16. Some nonclassical hyperbolic problems 17. Source terms and balance laws 18. Multidimensional hyperbolic problems 19. Multidimensional numerical methods 20. Multidimensional scalar equations 21. Multidimensional systems 22. Elastic waves 23. Finite-volume methods on quadrilateral grids Bibliography Index.
THE HAWAII SCUBA-2 LENSING CLUSTER SURVEY: NUMBER COUNTS AND SUBMILLIMETER FLUX RATIOS

We present deep number counts at 450 and 850 μm using the SCUBA-2 camera on the James Clerk Maxwell Telescope. We combine data for six lensing cluster fields and three blank fields to measure the counts over a wide flux range at each wavelength. Thanks to the lensing magnification, our measurements extend to fluxes fainter than 1 mJy and 0.2 mJy at 450 μm and 850 μm, respectively. Our combined data highly constrain the faint end of the number counts. Integrating our counts shows that the majority of the extragalactic background light (EBL) at each wavelength is contributed by faint sources with LIR < 1012 L⊙, corresponding to luminous infrared galaxies (LIRGs) or normal galaxies. By comparing our result with the 500 μm stacking of K-selected sources from the literature, we conclude that the K-selected LIRGs and normal galaxies still cannot fully account for the EBL that originates from sources with LIR < 1012 L⊙. This suggests that many faint submillimeter galaxies may not be included in the UV star formation history. We also explore the submillimeter flux ratio between the two bands for our 450 μm and 850 μm selected sources. At 850 μm, we find a clear relation between the flux ratio and the observed flux. This relation can be explained by a redshift evolution, where galaxies at higher redshifts have higher luminosities and star formation rates. In contrast, at 450 μm, we do not see a clear relation between the flux ratio and the observed flux.
Hypothesizing and Refining Causal Models

Abstract : An important common sense competence is the ability to hypothesize causal relations. This paper presents a set of constraints which make the problem of formulating causal hypotheses about simple physical systems a tractable one. The constraints include: 1) a temporal and physical proximity requirement; 2) a set of abstract causal explanations for changes in physical systems in terms of dependences between quantities; and 3) a teleological assumption that dependences in designed physical systems are functions. These constraints were embedded in a learning system which was tested in two domains: a sink and a toaster. The learning system successfully generated and refined naive causal models of these simple physical systems. The causal models which emerge from the learning process support causal reasoning - explanation, prediction, and planning. Inaccurate predictions and failed plans in turn indicate deficiencies in the causal models and the need to rehypothesize. Thus learning supports reasoning which leads to further learning. The learning system makes use of standard inductive rules of inference as well as the constraints of casual hypotheses to generalize its casual models. Finally, a simple example involving an analogy illustrates another way to repair incomplete causal models.
A qualitative analysis of virtues and strengths in persons living with early stage dementia informed by the values in action framework

Background Despite evidence that individuals’ virtues and character strengths can contribute to a sense of fulfillment, the majority of dementia research focuses on losses and decline. To date, virtues and character strengths in persons living with dementia is an understudied phenomena. This study begins to addresses this gap in the literature. Objectives The objectives of this study were to: (1) examine the expression of virtues and character strengths in persons living with dementia in the early stages; and (2) share implications and recommendations for strengths-based clinical practice and future research. Methods Qualitative data was utilized to examine virtues and character strengths among persons living with dementia. This data was derived from semi-structured interviews with 25 persons living with dementia age 65 or older (average age of 77.88). The interviews were audio recorded with consent, professionally transcribed, audit checked, and subjected to Interpretive Phenomenological analysis which was informed by the Values in Action (VIA) framework. Findings Each of the virtues and 24 corresponding character strengths from the VIA framework were observed in this sample. The most frequently observed character strengths were love, spirituality, perseverance, and gratitude. Implications Persons with dementia continue to express virtues and character strengths in the context of cognitive and functional changes. Positive strengths-based research and clinical practice should highlight and build upon these individual virtues and character strengths.
Impacts of COVID-19 on HIV/AIDS-Related Services in California

The degree to which COVID-19 has disrupted the advances in reducing new HIV infections and preventing AIDS-related deaths is unknown. We present findings related to the effect COVID-19 had on HIV, sexual health and harm reduction service delivery in the state of California. We conducted a qualitative rapid assessment with health care providers, as well as representatives from non-medical support service agencies serving clients living with HIV in a range of counties in California. Some organizations adapted fairly easily while others struggled or were unable to adapt at all. Clinics were better positioned than community-based organizations to accommodate COVID restrictions and to quickly reestablish services. Influential forces that softened or calcified the hardships created by COVID-19 included influx of funding, flexibility in managing funds, networking and relationships, and workforce vulnerabilities. These data clearly suggest that an enhanced level of flexibility within funding streams and reporting requirements should be continued.
Mechanisms for maintaining information in working memory

ABSTRACT The review by Slotnick is valuable for raising the important question of how much the hippocampal activity induced by novel stimuli is due to mechanisms for encoding into long-term memory, and how much is due to working memory. Slotnick’s paper implicitly defines working memory as being equivalent to sustained activation during the late delay period. In this commentary, we suggest that cognitive neuroscientists should consider a broader range of cellular and synaptic mechanisms for maintaining information in working memory.
EFFECTS OF INTERMEDIATE MASS BLACK HOLES ON NUCLEAR STAR CLUSTERS

Nuclear star clusters (NSCs) are dense stellar clusters observed in galactic nuclei, typically hosting a central massive black hole. Here we study the possible formation and evolution of NSCs through the inspiral of multiple star clusters hosting intermediate mass black holes (IMBHs). Using an N-body code, we examine the dynamics of the IMBHs and their effects on the NSC. We find that IMBHs inspiral to the core of the newly formed NSC and segregate there. Although the IMBHs scatter each other and the stars, none of them is ejected from the NSC. The IMBHs are excited to high eccentricities and their radial density profile develops a steep power-law cusp. The stars also develop a power-law cusp (instead of the central core that forms in their absence), but with a shallower slope. The relaxation rate of the NSC is accelerated due to the presence of IMBHs, which act as massive perturbers. This in turn fills the loss cone and boosts the tidal disruption rate of stars both by the MBH and the IMBHs to a value excluded by rate estimates based on current observations. Rate estimates of tidal disruptions can therefore provide a cumulative constraint on the existence of IMBHs in NSCs.
Individual functional parcellation revealed compensation of dynamic limbic network organization in healthy ageing

Using group‐level functional parcellations and constant‐length sliding window analysis, dynamic functional connectivity studies have revealed network‐specific impairment and compensation in healthy ageing. However, functional parcellation and dynamic time windows vary across individuals; individual‐level ageing‐related brain dynamics are uncertain. Here, we performed individual parcellation and individual‐length sliding window clustering to characterize ageing‐related dynamic network changes. Healthy participants (n = 637, 18–88 years) from the Cambridge Centre for Ageing and Neuroscience dataset were included. An individual seven‐network parcellation, varied from group‐level parcellation, was mapped for each participant. For each network, strong and weak cognitive brain states were revealed by individual‐length sliding window clustering and canonical correlation analysis. The results showed negative linear correlations between age and change ratios of sizes in the default mode, frontoparietal, and salience networks and a positive linear correlation between age and change ratios of size in the limbic network (LN). With increasing age, the occurrence and dwell time of strong states showed inverted U‐shaped patterns or a linear decreasing pattern in most networks but showed a linear increasing pattern in the LN. Overall, this study reveals a compensative increase in emotional networks (i.e., the LN) and a decline in cognitive and primary sensory networks in healthy ageing. These findings may provide insights into network‐specific and individual‐level targeting during neuromodulation in ageing and ageing‐related diseases.