Miracle-dz/UniFAR-FTUs huggingface dataset:
Brain signal complexity in adults with Down syndrome: Potential application in the detection of mild cognitive impairment

Background Down syndrome (DS) is considered the most frequent cause of early-onset Alzheimer’s disease (AD), and the typical pathophysiological signs are present in almost all individuals with DS by the age of 40. Despite of this evidence, the investigation on the pre-dementia stages in DS is scarce. In the present study we analyzed the complexity of brain oscillatory patterns and neuropsychological performance for the characterization of mild cognitive impairment (MCI) in DS. Materials and methods Lempel-Ziv complexity (LZC) values from resting-state magnetoencephalography recordings and the neuropsychological performance in 28 patients with DS [control DS group (CN-DS) (n = 14), MCI group (MCI-DS) (n = 14)] and 14 individuals with typical neurodevelopment (CN-no-DS) were analyzed. Results Lempel-Ziv complexity was lowest in the frontal region within the MCI-DS group, while the CN-DS group showed reduced values in parietal areas when compared with the CN-no-DS group. Also, the CN-no-DS group exhibited the expected pattern of significant increase of LZC as a function of age, while MCI-DS cases showed a decrease. The combination of reduced LZC values and a divergent trajectory of complexity evolution with age, allowed the discrimination of CN-DS vs. MCI-DS patients with a 92.9% of sensitivity and 85.7% of specificity. Finally, a pattern of mnestic and praxic impairment was significantly associated in MCI-DS cases with the significant reduction of LZC values in frontal and parietal regions (p = 0.01). Conclusion Brain signal complexity measured with LZC is reduced in DS and its development with age is also disrupted. The combination of both features might assist in the detection of MCI within this population.
A trace formula for Jacobi forms.

The purpose of this paper is to state and prove a general trace formula for Jacobi forms. The exact Statement of this trace formula can be found in § l, especially Theorem 1. In this Statement there occurs a certain quantity Gm(<! ;), the trace of a certain operator on a space of fundamental theta functions. This quantity is computed explicitly in § 4 ( Theorems 2 and 3). In the course of these latter calculations two minor results, which may be of independent interest, incidentally drop out: a Gauss sum reciprocity law (Proposition 4. 2) and a nice formula for Gauss sums associated to binary quadratic forms (Theorem 3). Two proofs of the trace formula will be given, in § 2 and in § 3. The main ingredient of the first proof is the construction of a reproducing kernel function for Jacobi forms (Lemma 2. l and Proposition 2. 2), while in the second proof the trace formula for Jacobi forms is reduced to the trace formula for modular forms of halfintegral weight äs given in [Shi]. The first method is nicer because it is elementary and completely self-contained, but for convergence reasons we must assume that the weight k is greater than 3. The second proof works for all weights and is shorter modulo results in the literature, but it is considerably more abstract and is longer if one wants a complete proof "from scratch".
Conflict side of creativity: Role of supervisory support and team affective tone in facilitating creative idea validation

Purpose We seek to understand whether relationship conflicts of co-workers affect the validation of creative ideas or not. Furthermore, what boundary conditions may help prevent potential drawbacks of relationship conflicts with co-workers to validate their creative ideas? Design/methodology/approach The proposed model was tested by using multisource data collected across two points in time from final year nursing students and medical dispensers of five nursing colleges of south-Punjab, Pakistan. The model was analyzed with Mplus for random coefficient models for direct effects, mediated moderation, and UCINET for central tendency of creative idea validation. Findings It was found that relationship conflicts with co-workers were negatively related to their validation of creative ideas. However, supervisory support and team affective tone independently attenuate the negative effects of relationship conflicts with co-workers and the validation of creative ideas. Positive affective tone emerged as a positive predictor of creative idea validation. Additionally, positive affective tone as affected by supervisory support attenuated the negative relationship between relationship conflicts with co-workers and their validation of creative ideas. Finally, the relationship between relationship conflicts with co-workers and their validation of creative ideas is more positive when both supervisory support and positive affective tone are high, however, low otherwise. Practical implications This study will help policymakers understand what might be hindering the transfer of creative ideas to influential others (Leaders, Managers, etc.) and what they need to do to enhance the creative pool of their organizations. Although developing an environment that fosters creativity is important for the organizations, developing strategies to manage relationship conflicts related to supervisory support and positive affective tone will help transfer creative ideas to higher offices even when there are dysfunctional conflicts. Originality/value This research shifts the conventional focus of understanding creativity from the generating side by explaining challenges that creative individuals face in promoting creative ideas with more criticism and offense by coworkers than support. Also, the interplay between the relationship conflicts with co-workers and team affective tone affected by supervisory support for validation of creative ideas enhanced our understanding of the boundary conditions of relationship conflict and creative idea validation.
Quantitative hematoma heterogeneity associated with hematoma growth in patients with early intracerebral hemorrhage

Background Early hematoma growth is associated with poor functional outcomes in patients with intracerebral hemorrhage (ICH). We aimed to explore whether quantitative hematoma heterogeneity in non-contrast computed tomography (NCCT) can predict early hematoma growth. Methods We used data from the Risk Stratification and Minimally Invasive Surgery in Acute Intracerebral Hemorrhage (Risa-MIS-ICH) trial. Our study included patients with ICH with a time to baseline NCCT <12 h and a follow-up CT duration <72 h. To get a Hounsfield unit histogram and the coefficient of variation (CV) of Hounsfield units (HUs), the hematoma was segmented by software using the auto-segmentation function. Quantitative hematoma heterogeneity is represented by the CV of hematoma HUs. Multivariate logistic regression was utilized to determine hematoma growth parameters. The discriminant score predictive value was assessed using the area under the ROC curve (AUC). The best cutoff was determined using ROC curves. Hematoma growth was defined as a follow-up CT hematoma volume increase of >6 mL or a hematoma volume increase of 33% compared with the baseline NCCT. Results A total of 158 patients were enrolled in the study, of which 31 (19.6%) had hematoma growth. The multivariate logistic regression analysis revealed that time to initial baseline CT (P = 0.040, odds ratio [OR]: 0.824, 95 % confidence interval [CI]: 0.686–0.991), “heterogeneous” in the density category (P = 0.027, odds ratio [OR]: 5.950, 95 % confidence interval [CI]: 1.228–28.828), and CV of hematoma HUs (P = 0.018, OR: 1.301, 95 % CI: 1.047–1.617) were independent predictors of hematoma growth. By evaluating the receiver operating characteristic curve, the CV of hematoma HUs (AUC = 0.750) has a superior predictive value for hematoma growth than for heterogeneous density (AUC = 0.638). The CV of hematoma HUs had an 18% cutoff, with a specificity of 81.9 % and a sensitivity of 58.1 %. Conclusion The CV of hematoma HUs can serve as a quantitative hematoma heterogeneity index that predicts hematoma growth in patients with early ICH independently.
The impact of the big five personality variables on self-employment survival

Based on large, representative Australian household panel, this study investigates to what extent the Big Five personality variables influence self-employment survival and differentiates between successful or unsuccessful exit. In addition, the influence of two moderating variables, tertiary education and the motivation to become self-employed, are considered. Contrary to expectations, we found no impact of the Big Fives variable on self-employment survival in general. In the case of unsuccessful exit, we found that entrepreneurs with a higher level of Conscientiousness tend to stay self-employed although they may not be satisfied with their job. Similarly, entrepreneurs with a tertiary education prolong unsuccessfully self-employment stints, particularly if they exhibit higher level of Emotional Stability. Necessity-driven entrepreneurs exit unsuccessful stints earlier, especially if they exhibit a lower level of conscientiousness.
Ferritinophagy, a form of autophagic ferroptosis: New insights into cancer treatment

Ferritinophagy, a form of autophagy, is also an important part of ferroptosis, a type of regulated cell death resulting from abnormal iron metabolism involving the production of reactive oxygen species. As ferroptosis, autophagy and cancer have been revealed, ferritinophagy has attracted increasing attention in cancer development. In this review, we discuss the latest research progress on ferroptosis, autophagy-associated ferroptosis led by ferritinophagy, the regulators of ferritinophagy and promising cancer treatments that target ferritinophagy. Ferritinophagy is at the intersection of ferroptosis and autophagy and plays a significant role in cancer development. The discussed studies provide new insights into the mechanisms of ferritinophagy and promising related treatments for cancer.
An Asian case of combined 17α-hydroxylase/17,20-lyase deficiency due to homozygous p.R96Q mutation: A case report and review of the literature

Background Combined 17α-hydroxylase/17,20-lyase deficiency (17-OHD) is a very rare form of congenital adrenal hyperplasia (CAH) caused by mutations in the CYP17A1 gene. Almost 100 different mutations of the CYP17A1 gene have been reported, including p.R96Q mutation, but no case of p.R96Q mutation has been described in Asian populations. Case presentation We describe a 22-year-old female patient of 46,XY karyotype, who presented with pseudohermaphrodism, primary amenorrhea, underdeveloped secondary sexual characteristics, delayed epiphyseal healing, hypertension, and hypokalemia. The diagnosis of 17-OHD was reached by measurement of steroid hormones and abdominal CT scan and confirmed by genetic sequencing, which revealed a homozygous p.R96Q missense mutation in the CYP17A1 gene. The patient received treatment with dexamethasone and estradiol, and 4 months of follow-up showed that both blood pressure and potassium were well controlled. Conclusions This is the first Asian case of CAH caused by a homozygous p.R96Q missense mutation in the CYP17A1 gene. Herein, we highlight the role of inguinal hernia in the early diagnosis of female 17-OHD and the necessity of removing the ectopic testis.
Sublethal effects and reproductive hormesis of emamectin benzoate on Plutella xylostella

The diamondback moth (DBM), Plutella xylostella L. , is an important pest of cruciferous vegetables, and population control mainly depends on chemical pesticides. Emamectin benzoate is a highly effective insecticide used for controlling DBM. However, it is unknown how the sublethal effects of low concentration residues of emamectin benzoate on DBM. So the population development sublethal effects of emamectin benzoate, at LC5, LC10, and LC20 with concentrations of 0.014 mg/L, 0.024 mg/L and 0.047 mg/L, respectively, on adult DBM and their progeny were investigated in this study. The pupal weight, pupal period, female fecundity, and vitellin content of the F0 DBM generation increased significantly compared to the control. And the single female oviposition number of DBM was increased by 20.21% with LC20 treatment. The pupation rate, adult longevity and ovariole length of the treatment groups decreased significantly. The fecundity of DBM in the treatment groups increased, and this increased the population by a presumptive 13.84%. Treatment also led to the shortening of ovarioles and the reduction of egg hatching, and increased pupal weight in the F1 generation. We concluded that the effects of sublethal/low concentration emamectin benzoate on the different life stages of DBM were variable, and the reproductive hormesis on DBM adults were attractive findings.
Artificial neural networks for non-linear age correction of diffusion metrics in the brain

Human aging is characterized by progressive loss of physiological functions. To assess changes in the brain that occur with increasing age, the concept of brain aging has gained momentum in neuroimaging with recent advancements in statistical regression and machine learning (ML). A common technique to assess the brain age of a person is, first, fitting a regression model to neuroimaging data from a group of healthy subjects, and then, using the resulting model for age prediction. Although multiparametric MRI-based models generally perform best, models solely based on diffusion tensor imaging have achieved similar results, with the benefits of faster data acquisition and better replicability across scanners and field strengths. In the present study, we developed an artificial neural network (ANN) for brain age prediction based upon tract-based fractional anisotropy (FA). Consequently, we investigated if this age-prediction model could also be used for non-linear age correction of white matter diffusion metrics in healthy adults. The brain age prediction accuracy of the ANN (R2 = 0.47) was similar to established multimodal models. The comparison of the ANN-based age-corrected FA with the tract-wise linear age-corrected FA resulted in an R2 value of 0.90 [0.82; 0.93] and a mean difference of 0.00 [−0.04; 0.05] for all tract systems combined. In conclusion, this study demonstrated the applicability of complex ANN models to non-linear age correction of tract-based diffusion metrics as a proof of concept.
Oral infections in oral cancer survivors: A mini-review

The oral cancer survivors are a group of special individuals whose disease affect anatomical structures with a key role in identity and communication and a fundamental role in basic human functions such as speaking, eating, swallowing and breathing. Thus, quality of life of these individuals can be impaired by the consequences of disease and treatments, in particular surgery and radiotherapy. Among others, infectious conditions of any nature, bacterial, viral, fungal, are a frequent finding among oral cancer survivors. In fact, the peculiar systemic and local conditions of these subjects are known to significantly modify the microbiota, which, besides facilitating opportunistic infections, can affect the cancer microenvironment, as well as alter the effects of the anti-cancer therapies. Similarly, mouth infections can also affect the prognosis of oral cancer survivors. Among the opportunistic infections, fungal are the most common infections affecting these subjects, since neutropenia resulting from cancer, as well as chemotherapy and/or radiotherapy treatments, promote the shift from the carrier state of Candida species, to pathogen state. Treatment of oral candidiasis can be difficult in oral cancer survivors, and good evidence supports clotrimazole as the most effective for prevention, and fluconazole as the one with the best risk-benefit profile. Probiotics, although promising, need better evidence to be considered an effective treatment or preventive measure.
Exploring the mediating effects of negative and positive religious coping between resilience and mental well-being

Background: The purpose of the study was to examine more thoroughly the relationship between trait resilience and mental well-being. Although research demonstrates that this relationship is partially mediated by stress-related variables, no study has taken into account the mediating role of religious coping. We examined the mediating role of both variants of religious coping, positive and negative, along with specific strategies within the scope of religious coping strategies in a group of practicing Catholics. Method: Participants were 317 people aged 19–60 years (M = 24.34; SD = 6.30). The respondents indicated their gender and age, and then completed the RS-14 (trait resilience), RCOPE (religious coping), and WEMWBS (mental well-being) scales. Results: The results displayed a significant relationship between resilience and mental well-being (r = 0.67; p < 0.001). The relationship between resilience and positive religious coping was negligible (r = 0.09; p = 0.74), contrary to the relationship between resilience and negative coping that was significant but weak (r = −0.29; p < 0.001). Although the relationships between overall negative and positive religious coping with mental well-being were irrelevant, we found significant relationships between some strategies and mental well-being. The mediation analysis has demonstrated that the general negative religious coping and the strategies of demonic reappraisal, passive religious deferral, and spiritual discontent have enhanced the positive relationship between resilience and mental well-being. Contrary to expectation, positive strategies did not mediate the relationship between resilience and mental well-being, except religious practices (c′ path totaled β = 0.66; t = 15.74, p < 0.001). The insignificant mediation effect can stem from the fact that the relationship between positive religious coping and stress is noticeable only in the long term. We controlled age and sex as statistically significant covariates so that the mediation effects obtained were devoid of the influence of those critical variables on the models. Conclusion: This is the first study to investigate the role of religious coping as a mediator in the relationship between resilience and mental well-being.
Alpha emitter radium-223 in patients with metastatic castration-resistant prostate cancer: A cost-utility analysis

Objective: To assess the cost effectiveness of radium-223 dichloride for patients with metastatic castration-resistant prostate cancer (mCRPC) in China. Materials and methods: A Markov model was developed to estimate the long-term health and economic outcomes of radium-223 plus best standard care (BSC) treatment and BSC only for bone mCRPC patients over a lifetime horizon. The patients and interventions were modeled according to the ALSYMPCA trial. Costs were collected from a Chinese health system perspective. Utility values were derived from the published literature. The base-case model results were quality-adjusted life year (QALY), total cost, and incremental cost-utility ratio (ICUR). Uncertainty analyses were performed to assess the robustness of our conclusions. Results: Compared with the BSC arm, radium-223 achieved an excess 0.344 QALYs with an incremental cost of $29,459, resulting in an ICUR of $85,647 per QALY. The probability of Ra-223 being cost effective for the patients with bone mCRPC was sharply low (<0.5%) at a willingness-to-pay threshold of $38,136/QALY. Uncertainty analyses revealed that the model is robust to all the input parameters. Conclusion: Radium-223 is unlikely to be cost effective in patients with bone mCRPC at the current WTP threshold, from a Chinese health system perspective. In affluent areas with a high per-capita GDP, radium-223 therapy may be cost effective.
Human stefin B: from its structure, folding, and aggregation to its function in health and disease

Mutations in the gene for human stefin B (cystatin B) cause progressive myoclonic epilepsy type 1 (EPM1), a neurodegenerative disorder. The most common change is dodecamer repeats in the promoter region of the gene, though missense and frameshift mutations also appear. Human stefin B primarily acts as a cysteine cathepsin inhibitor, and it also exhibits alternative functions. It plays a protective role against oxidative stress, likely via reducing mitochondrial damage and thus generating fewer mitochondrial reactive oxygen species (ROS). Accordingly, lack of stefin B results in increased inflammation and NLRP3 inflammasome activation, producing more ROS. The protein is cytosolic but also has an important role in the nucleus, where it prevents cleavage of the N terminal part of histone 3 by inhibiting cathepsins L and B and thus regulates transcription and cell cycle. Furthermore, it has been shown that stefin B is oligomeric in cells and that it has a specific role in the physiology of the synapse and in vesicular transport. On the basis of my research team’s data on the structure, folding, and aggregation of stefin B, we have proposed that it might regulate proteostasis, possessing a chaperone-like function. In this review, I synthesize these observations and derive some conclusions on possible sources of EPM1 pathology. The interaction partners of stefin B and other gene mutations leading to EPM1-like pathology are discussed and common pathways are pinpointed.
The potential for biochar application in “Shatangju” (Citrus reticulate cv.) orchard on acid red soil: Biochar prepared from its organic waste in an orchard

Carbonization of agricultural and forestry wastes is the main use of biochar application in agriculture. In this study, the effects of biochar on the physical and chemical properties of soil and diversity in rhizosphere microorganisms, leaf nutrients and fruit quality of acid red soil in “Shatangju” (Citrus reticulate cv.) orchard were studied using organic wastes and small-scale carbonization furnaces from orchards were used to produce biochar. The results showed that the finished rate of biochar produced from the organic wastes in the orchard was approximately 37%, and the carbon content of the finished product was as high as 80%. The results suggested that the biochar produced in the orchard could meet the annual consumption of the orchard. Applying biochar can improve the physical and chemical properties of acid soil in the “Shatangju” orchard by enhancing the availability of various mineral nutrients such as nitrogen, phosphorus, potassium, calcium, magnesium and boron. The species and quantity of root and rhizosphere microbial communities (fungi, bacteria and archaea) increased, and the dominant bacterial group changed, manifested in the increase in microbial diversity. Biochar directly affected the soil pH value and increased the soil organic carbon content, which may be the main reason for the change in microbial diversity in the soil and rhizosphere of “Shatangju” in the orchard and pot tests. The fruit quality of each treatment group with biochar was also better than that of the control group and improved fruit coloring. In the pure soil test, whether or not chemical fertilizer was applied, 3% biochar amendments can provide a suitable pH value for “Shatangju” growth and are relatively stable. Regardless of whether or not fertilizer was applied, 1.5%-3% biochar improved the soil in the pot test. In the field, the biochar at a rate of 2.4 kg/plant to 3.6 kg/plant, respectively, was the best in improving soil physical and chemical properties, foliar nutrition and fruit quality. Therefore, the amount of biochar added in the open environment (if the garden) can be slightly adjusted according to the results of the closed environment test (pure soil test and pot test). In this experiment, we explored the self-recycling of organic carbon, mainly through the preparation of a simple small-scale biochar furnace suitable for the use by orchards, and selected the appropriate amount of biochar to improve the physical and chemical conditions of “Shatangju” orchard soil and increase fruit quality.