Miracle-dz/UniFAR-FTUs huggingface dataset:
Design and Characterization of a 60 GHz Low-Noise Ampliﬁer in GaAs m-HEMT Technology for Radar Detection Systems

—This paper addresses the design of a 60 GHz low- noise ampliﬁer for radar detection systems. Based on an impulse architecture, the required characteristics of the ampliﬁer are determined to improve the system performance, especially in terms of range. The choice of the design technology is based on a detailed comparative study. Then, the ampliﬁer is designed in a 70 nm gallium-arsenide metamorphic high electron mobility transistor technology. It includes three-stages transistors with inductive degeneration for a suitable trade-off between gain and noise. Critical design points related to coupling phenomena are identiﬁed in the layout realization. To limit these coupling effects, a progressive optimization method is used. The optimized ampliﬁer achieves a gain of 14 . 3 dB and a noise factor of 2 . 1 dB at 60 GHz. The simulated non-linear characteristics show an input 1 dB compression point IP 1 dB = − 9 . 6 dBm and an input third-order intercept point IIP 3 ≈ − 4 dBm. A good impedance matching at the input ( S 11 < − 15 . 4 dB) and the output ( S 22 < − 16 . 3 dB) is obtained in the frequency band of interest. The designed circuit consumes a total direct current power of 13 . 5 mW and occupies an area of 1 . 47 × 1 . 0 mm 2 . In addition, the sensitivity characterization of the ampliﬁer to voltage biasing, temperature and input impedance variations shows a good robustness of
current on stereotactic body radiation therapy for pancreatic cancer.

: Pancreatic cancer is a formidable malignancy with poor outcomes. The majority of patients are unable to undergo resection, which remains the only potentially curative treatment option. The management of locally advanced (unresectable) pancreatic cancer is controversial; however, treatment with either chemotherapy or chemoradiation is associated with high rates of local tumor progression and metastases development, resulting in low survival rates. An emerging local modality is stereotactic body radiation therapy (SBRT), which uses image-guided, conformal, high-dose radiation. SBRT has demonstrated promising local control rates and resultant quality of life with acceptable rates of toxicity. Over the past decade, increasing clinical experience and data have supported SBRT as a local treatment modality. Nevertheless, additional research is required to further evaluate the role of SBRT and improve upon the per-sistently poor outcomes associated with pancreatic cancer. This review discusses the existing clinical experience and technical implementation of SBRT for pancreatic cancer and highlights the directions for ongoing and future studies.
Diagnostic accuracy of computed tomography coronary angiography in patients with an intermediate pre-test likelihood for coronary artery disease

Data on the diagnostic accuracy of multi-slice computed tomography coronary angiography (CTA) have been mostly derived in patients with a high pre-test likelihood for coronary artery disease (CAD). Systematic comparison with invasive angiography in patients with intermediate pre-test likelihood is scarce. The purpose of the present study was to determine the diagnostic accuracy of CTA in patients without known CAD with an intermediate pre-test likelihood. 61 patients (61% male, and average age 57±9 years) referred for invasive coronary angiography underwent additional 64-slice CTA. 920 segments were identified on invasive coronary angiography of which 885 (96%) were interpretable on CTA. Invasive coronary angiography identified a significant stenosis (≥50% luminal narrowing) in 29 segments, of which 23 were detected on CTA. As a result, sensitivity, specificity, positive predictive value and negative predictive value were 79%, 98%, 61%, and 99% respectively. On a patient level, sensitivity, specificity, positive predictive value, and negative predictive value were respectively 100%, 89%, 76%, and 100%. Importantly, CTA correctly ruled out the presence of significant stenosis in 66% (40 of 61) of the total population. In conclusion, the current study confirms that CTA has an excellent diagnostic accuracy in the target population of patients with an intermediate pre-test likelihood. Notably, the high negative predictive value allowed rule out of significant stenosis in a large proportion of patients. CTA may therefore be used as a highly effective gatekeeper for invasive coronary angiography.
Quantized successor pre-coding : a method for spatial multiplexing in MIMO systems with limited feedback and temporally-correlated channels

Quantized Successor Pre-coding: A Method for Spatial Multiplexing in MIMO Systems with Limited Feedback and Temporally-Correlated Channels Patrick Karl Sisterhen, MSE The University of Texas at Austin, 2010 Supervisor: R.W. Heath, Jr. The use of feedback to provide channel state information to the transmitter can greatly improve the performance of a communication system. However, the amount of information required to characterize a time-varying MIMO channel can exceed the capacity of the feedback channel. This paper surveys research in limited feedback systems, which employ a number of methods to reduce the information and improve performance in multiantenna communication systems. This paper also presents a new method, Quantized Successor Pre-coding (QSP), that exploits time-correlation to implement spatial multiplexing in a MIMO system using very little feedback. QSP uses an ordered codebook of pre-coders and transmission modes to reduce the feedback to a single bit. Simulations of QSP demonstrate a substantial performance improvement relative to open-loop spatial multiplexing.
Idiopathic thrombocytopenic purpura induced by nivolumab in a metastatic melanoma patient with elevated on

1. Parker C, Gillesen S, Heidenreich A, Horwich A. Cancer of the prostate: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2015; 26(Suppl 5): v69–v77. 2. Gravis G, Fizazi K, Joly F et al. Androgen-deprivation therapy alone or with docetaxel in non-castrate metastatic prostate cancer (GETUG-AFU 15): a randomised, openlabel, phase 3 trial. Lancet Oncol 2013; 14: 149. 3. Sweeney C, Chen Y-H, Carducci M et al. Chemohormonal therapy in metastatic hormone-sensitive prostate cancer. N Engl J Med 2015; 373: 737–746. 4. James ND, Sydes MR, Mason MD et al. Docetaxel and/or zoledronic acid for hormone-naïve prostate cancer: first overall survival results from STAMPEDE (NCT00268476). J Clin Oncol 2015; 33(suppl); abstr 5001. 5. Templeton AJ, Vera-Badillo FE, Wang L et al. Translating clinical trials to clinical practice: outcomes of men with metastatic castration resistant prostate cancer treated with docetaxel and prednisone in and out of clinical trials. Ann Oncol 2013; 24: 2972–2977.
Evolution of Galaxies in Clusters

In this paper I show recent results of our studies on the evolution of an isolated cluster of galaxies using N -body simulations. In Sensui, Funato & Makino (1999) only one initial cluster model are investigated. In the present study, we varied the initial model of galaxies and clusters, and studied the dependence of evolution on initial conditions. We found that the mass of galactic halos are stripped and a common halo develops for any cluster models. Using result of scattering experiments of two halo-halo encounters, we show that the growth rate of the common halo (and complimentarily decrease rate of average mass of galactic halos) can be explained as a result of stripping due to cumulative encounters between two galactic halos. We also found that the galaxies evolved so as to satisfy the relation between the masses of galaxies m gx and their velocity dispersion σ gx expressed as m gx ∝ σ 3∼4 gx for all galaxy models as a consequence of their dynamical evolution through galaxy-galaxy interactions. We discuss the relation between our result and the observed Faber-Jackson relation.
Thyme Antimicrobial E ﬀ ect in Edible Films with High Pressure Thermally Treated Whey Protein Concentrate

: Application of high pressure-thermal treatment (600 MPa and 70 ◦ C, 20 min) for obtaining edible ﬁlms functionalized with thyme extracts have been studied in order to evaluate the antimicrobial capacity of ﬁlms structure to retain and release the bioactive compounds. The high pressure-thermally treated ﬁlms (HPT) were compared with the thermally treated (TT) ones (80 ± 0.5 ◦ C, 35 min). The ﬁlm structures were analyzed and the sorption isotherms, water vapor permeability, antimicrobial activity and the volatile ﬁngerprints by GC / MS were performed. The HPT ﬁlm presented more binding sites for water chemi-sorption than TT ﬁlms and displayed signiﬁcantly lower WVP than TT ﬁlms ( p < 0.05). TT ﬁlms displayed slightly, but signiﬁcant higher, antimicrobial activity ( p < 0.05) against Geotrichum candidum in the ﬁrst day and against Bacillus subtilis in the 10th day of storage. The HPT ﬁlm structure had ~1.5-fold higher capacity to retain volatiles after drying compared to TT ﬁlms. From the HPT ﬁlms higher amount of p-cymene and α -terpinene was volatilized during 10 days of storage at 25 ◦ C, 50% RH while from the TT ﬁlms higher amount of caryophyllene and carvacrol were released. During storage HPT ﬁlms had a 2-fold lower capacity to retain monoterpenes compared to TT ﬁlms.
University of Birmingham Protein shedding in urothelial bladder cancer

Background: Better biomarkers must be found to develop clinically useful urine tests for bladder cancer. Proteomics can be used to identify the proteins released by cancer cell lines and generate candidate markers for developing such tests. Methods: We used shotgun proteomics to identify proteins released into culture media by 8 bladder cancer cell lines. These data were compared with protein expression data from the Human Protein Atlas. EGFR was identified as a candidate biomarker and measured by ELISA in urine from 60 non-cancer control subjects and from 436 patients with bladder cancer and long-term clinical follow-up. Results: Bladder cancer cell lines shed soluble EGFR ectodomain. Soluble EGFR is also detectable in urine and is highly elevated in some patients with high-grade bladder cancer. Urinary EGFR is an independent indicator of poor bladder cancer specific survival with a hazard ratio of 2.89 (95% CI 1.81-4.62, p<0.001). EGFR, is released into the urine in a soluble form and is a promising biomarker for rapidly identifying UBC patients with the most aggressive disease. This work represents the first description of the prognostic value of soluble urinary EGFR in UBC, alone and in combination with soluble urinary EpCAM (Bryan et al , 2014b). analysis. The multivariable analysis showed that elevated urinary
University of Birmingham Oxytocin effect on collective decision making

Collective decision making often benefits both the individuals and the group in a variety of contexts. However, for the group to be successful, individuals should be able to strike a balance between their level of competence and their influence on the collective decisions. The hormone oxytocin has been shown to promote trust, conformism and attention to social cues. We wondered if this hormone may increase participants ’ (unwarranted) reliance on their partners ’ opinion, resulting in a reduction in collective benefit by disturbing the balance between influence and competence. To test this hypothesis we employed a randomized double-blind placebo-controlled design in which male dyads self-administered intranasal oxytocin or placebo and then performed a visual search task together. Compared to placebo, collective benefit did not decrease under oxytocin. Using an exploratory time dependent analysis, we observed increase in collective benefit over time under oxytocin. Moreover, trial-by-trial analysis showed that under oxytocin the more competent member of each dyad was less likely to change his mind during disagreements, while the less competent member showed a greater willingness to
False alarms: How early warning signals predict abrupt sea ice loss

Uncovering universal early warning signals for critical transitions has become a coveted goal in diverse scientiﬁc disciplines, ranging from climate science to ﬁnancial mathematics. There has been a ﬂurry of recent research proposing such signals, with increasing autocorrelation and increasing variance being among the most widely discussed candidates. A number of studies have suggested that increasing autocorrelation alone may suﬃce to signal an impending transition, although some others have questioned this. Here we consider variance and autocorrelation in the context of sea ice loss in an idealized model of the global climate system. The model features no bifurcation, nor increased rate of retreat, as the ice disappears. Nonetheless, the autocorrelation of summer sea ice area is found to increase in a global warming scenario. The variance, by contrast, decreases. A simple physical mechanism is proposed to explain the occurrence of increasing autocorrelation but not variance when there is no approaching bifurcation. Additionally, a similar mechanism is shown to allow an increase in both indicators with no physically attainable bifurcation. This implies that relying on autocorrelation and variance as early warning signals can raise false alarms in the climate system, warning of “tipping points” that are not actually there.
A Novel Approach to Sentence Extraction Using Font Features

(cid:3)(cid:3)(cid:3)(cid:3)(cid:3)(cid:3)(cid:3)(cid:3)(cid:3)(cid:3)(cid:3)(cid:3)(cid:3)(cid:3)(cid:3) As information overload grows day by day, systems that can automatically summarize documents becomes increasingly studied and used. In this paper we have given a novel statistical approach for text summarization of a single source document by sentence extraction using font features. We rank each sentence in the document by assigning a weight value to each word of the sentence and a boost factor is also added to those terms which appear in bold, italic or underlined or any combination of these features. In this paper we improved our result in comparison to our previous paper: [14].
ANALYSIS OF ANTIBODY RESPONSES TO STREPTOCOCCAL AND TISSUE ANTIGENS IN PATIENTS WITH ACUTE RHEUMATIC FEVER by

Acute Rheumatic Fever (ARF) is an autoimmune disease occurring in individuals following untreated group A streptococcal infection believed to be triggered by antibodies to bacterial components that cross-react with human tissues. A multiplexed immunoassay was developed for the simultaneous quantitation of antibodies to nine different streptococcal related antigens including streptolysin 0 (SLO), DNase B, Collagens I and IV, fibronectin, myosin, group A carbohydrate, M6 protein, and C5 peptidase. Development of the assay involved testing of several different types of microspheres as well serum diluent formulations in an effort to reduce nonspecific binding of antibodies. Optimal coupling conditions for both protein and carbohydrate antigens to the microspheres were also determined. Monoclonal antibodies were used to determine antigen coupling efficiencies and cross-reactive epitopes of the different antigens. The multiplexed assay was then used to quantitate antibody responses in 49 ARF, 58 pharyngitis patients, and age and sex matched controls in samples collected at initial disease onset, and at 4 weeks, 6 months, and 1 year after diagnosis. Through the selection of microspheres and serum diluent, nonspecific antibody binding was reduced by 17%. Different formulations of the coupling buffer were found to greatly influence the efficiency of coupling antigens to the carboxylated microspheres. Monoclonal antibodies against the different antigens demonstrated assay specificity as well as sensitivities of less than 1 nglml of antibody. Antibody responses were significantly higher for SLO, DNase B, M6 protein, group A carbohydrate, and the crossreactive antigens collagen I and myosin in ARF compared to pharyngitis patients (psO.05). Moreover, we found significantly elevated antibody responses in the ARF patients with rheumatic heart disease (RHD) to fibronectin and collagen I, compared to ARF patients without heart disease. The major differences between the ARF patients with and without carditis appear to be in the immune response to the putative heart valve components, collagen I and fibronectin.
Deﬁciency of Pkc1 activity aﬀects glycerol metabolism in Saccharomyces cerevisiae

Protein kinase C is apparently involved in the control of many cellular systems: the cell wall integrity pathway, the synthesis of ribosomes, the appropriated reallocation of transcription factors under speciﬁc stress conditions and also the regulation of N -gly-cosylation activity. All these observations suggest the existence of additional targets not yet identiﬁed. In the context of the control of carbon metabolism, previous data had demonstrated that Pkc1p might play a central role in the control of cellular growth and metabolism in yeast. In particular, it has been suggested that it might be involved in the derepression of genes under glucose-repres-sion by driving an appropriated subcellular localization of transcriptional factors, such as Mig1p. In this work, we show that a pkc 1 D mutant is unable to grow on glycerol because it cannot perform the derepression of the GUT1 gene that encodes glycerol kinase. Additionally, active transport is also partially aﬀected. Using this phenotype, we were able to isolate a new pkc 1 D revertant. We also isolated two transformants identiﬁed as the nuclear exportin Msn5 and the histone deacetylase Hos2 extragenic suppressors of this mutation. Based on these results, we postulate that Pkc1p may be involved in the control of the cellular localization and/or regulation of the activity of nuclear proteins implicated in gene expression. Elsevier
“ASSOCIATION OF CXCL8 -251 T>A GENE POLYMORPHISM IN DIABETIC NEPHROPATHY AND CARDIOVASCULAR DISEASE IN WEST INDIAN POPULATIONS”

Type 2 diabetes mellitus (T2DM) is one of the most important global public health problems which is rapidly increasing and it is considered an epidemic disorder worldwide.CXCL8 Chemokine (C-X-C motif) has been recognized as a central player in type 2 diabetes mellitus, diabetic nephropathy and cardiovascular disease. The aim was to find the relationship between CXCL8 -251 A>T polymorphisms and their association with DN, cardiovascular disease (CVD) in type 2 diabetic patients. The population consisted of 631 participants (458 males and 173 females) allocated into six groups for the study. The first group was healthy participants (n=143); the second group was T2DM patients (DM without any complication, n=103); the third group diabetic nephropathy with diabetes (DN+DM, n=102). The fourth group was non diabetic nephropathy (NDN-DM, n=108) the fifth group was cardiovascular patient with diabetes (CVD+DM, n=81) and the sixth group was non diabetic cardiovascular (NDCV-DM, n=94). The polymorphism were analyzed by PCR-RFLP using Mfe I restriction enzymes which was checked on 3% agarose gen consisting of ethidium bromide for detection of restricted band. The aim of the present study was to investigate the association between CXCL8 gene polymorphisms (-251 T>A) polymorphism in West Indian population. This study is aimed to evaluating the association of CXCL-8 gene polymorphisms (-251 T>A) with complicated and uncomplicated type 2 diabetes mellitus. AT genotype are higher in T2DM, DN and CVD patients compared with control ( P <0.05), In addition, the T allele of CXCL8 -251 T>A gene are more susceptible to DN and CVD.
Salt Uptake and Excretlon ln tJre Mangtove, Aaicennia mo;rinia(Forsk.)

235 seedlings of Avicerniannritwwere grown for 12 months in nurient solutions containing 0, 25, 50, 75, 100, 125 and 15070 artificial s€awater. The salt concentation in the various organs and salt excretion from the leaves were measured to examine the salt regulation in the seedlings. The wabr potential of vuious organs in relation 3o extemal media was measured concurrently wittr salt concentration in the seedlings to discuss ttre wuer potential adjustment. A . marhw was found to absorb a great amount of sodium (Na) and chloride (Cl-). The salt uptake increased wittr the increase of extemal salinity and reached no ttre ceiling level at around the normal extemal seawater. The salt concenEations in the seedlings were maintained at levels higher than those of extemal media. This contributed to produce water potential in the seedlings lower than that of extemal media. The salt excretion was found to be related positively with the salt concenration in leaves. It was concluded that A. marina seedlings equip'ped a workable mechanism of salinity regulation through absorption and excretion. And therefore it can survive in the high salinity environment.
The C-Type Lectin SIGNR1 Binds Schistosoma mansoni Antigens In Vitro, but SIGNR1-Deﬁcient Mice Have Normal Responses during Schistosome Infection (cid:1)

The de novo immune response to infectious organisms arises from the innate recognition of pathogen- associated molecular patterns (PAMPs) by the host’s pattern recognition receptors (PRRs). As the generation of type 2 cytokine responses by the human trematode parasite Schistosoma mansoni is glycan mediated, there is a particular potential role for a C-type lectin receptor (CLR) to mediate the innate recognition of schisto- some PAMPs. One such CLR, dendritic cell-speciﬁc intracellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN; CD209), has been shown to recognize glycans expressed by S. mansoni eggs. We show that SIGNR1 (SIGN-related 1; CD209b), a murine homologue of DC-SIGN that is expressed on macrophages, also binds both schistosome-soluble egg antigens and worm antigens in vitro. The generation of schistosome egg-induced pulmonary egg granulomas was not altered in SIGNR1-deﬁcient mice. Following S. mansoni infection, the SIGNR1-deﬁcient mice had an unaltered phenotype with an intact immunological response and no difference in pathology. In this study we demonstrate that although SIGNR1 recognizes S. mansoni antigens in vitro, this CLR is redundant during infection. This study highlights the ﬁnding that although there was binding of SIGNR1 to immunogenic factors produced in the S. mansoni life cycle, this recognition does not translate to a functional in vivo role for the PRR during infection.
Edinburgh Research Explorer Input frequency and lexical variability in phonological development

Although it has been often hypothesized that children learn to produce new sound patterns ﬁrst in frequently heard words, the available evidence in support of this claim is inconclusive. To re-examine this question, we conducted a survival analysis of word-initial consonant clusters produced by three children in the Providence Corpus (0;11–4;0). The analysis took account of several lexical factors in addition to lexical input frequency, including the age of ﬁrst production, production frequency, neighborhood density and number of phonemes. The results showed that lexical input frequency was a signiﬁcant predictor of the age at which the accuracy level of cluster production in each word ﬁrst reached 80%. The magnitude of the frequency eﬀect diﬀered across cluster types. Our ﬁndings indicate that some of the between-word variance found in the development of sound production can indeed be attributed to the frequency of words in the child’s ambient language.
Title : Ecophysiological Study of Paraburkholderia sp . 1 N under Soil Solution Conditions : 1 Dynamic Substrate Preferences and Characterization of Carbon Use Efficiency 2 3

3 Department of Civil and Environmental Engineering, McCormick School of Engineering and 10 Applied Science, Northwestern University, Evanston, IL, 60208, USA 11 12 Corresponding Author 13 #email: cem20@cornell.edu 14 15 16 17 18 19 20