Miracle-dz/UniFAR-FTUs huggingface dataset:
Medicinal Plants Against Coronavirus (SARS-COV-2) in Morocco Via Computational Virtual Screening Approach

With the spread of the coronavirus in all countries of the world and in the absence of a vaccine or effective treatment to inhibit the infection. Several medicinal plants are used by the Moroccan population either to treat or prevent infection. The frequent use of its plants without documentation of their effectiveness on the Covid-19 is justified by cultural and economic reasons and their pharmacological activity scientifically proven. The objective of this study is to evaluate the inhibitory effect of the main polyphenols and flavonoids of Syzygium aromaticum and citrus limon as well as the main organosulfur compounds of garlic against coronavirus 6lu7 protease and 6y2e protease using in-silico molecular docking analysis.The COVID-19 3CLpro/Mpro (PDB ID: 6LU7) and free enzyme of the SARS-CoV-2 (2019- nCoV) main protease (PBD ID: 6Y2E) structures were obtained from the https://www.rcsb. org/ website in . PDB format. The COVID-19 3CLpro/Mpro (PDB ID: 6LU7) and main protease (PBD ID: 6Y2E) were prepared using autodock tools from MGL Tools package http://mgltools.scripps. edu/. The reactive molecular dynamics simulations were performed using the software LAMMPS and the ReaxFF force field. In this force field, the general energy functionWe have docked 34 natural products belonging to the three medicinal plants. In 6LU7 protease, 24 compounds exhibited a binding affinity greater than or equal to -6 Kcal/mol. While, in 6Y2E protease, 6 compounds exhibited a binding affinity greater than or equal to -6 Kcal/mol.We found that ellagic acid, narirutin, neoeriocitrin and neohesperidin are highly suggested as an inhibitor of SARS-COV-2.
Training Needs of Rural Youth towards Agri-Enterprises

The study is an attempt to understand training needs in areas of agrienterprises. Investigation was carried out in three regions of Andhra Pradesh. Exploratory research design was used. The respondents (n=240) were the youth residing in the villages at the time of investigation. Simple random sampling technique was used for sample collection from twenty four villages. Pre-tested interview schedule was used for data collection. The inferential statistical tools like mean, standard deviation, frequency, percentage were used for analysis of data. An attempt was made to assess the areas of training needs to be focused mainly for agripreneurs to run their agri-enterprises smoothly. Manufacturing techniques (2.69) ranked first among the list of areas training needs for agripreneurs.
Ocular disorders associated with obstructive sleep apnea: A review

Recently there has been upsurge in the cases of Obstructive Sleep Apnea (OSA) with increased prevalence of obesity in the general population. It has been continuously proved that OSA and metabolic syndrome go hand in hand and hence OSA predisposes an individual to a series of cardio-vascular disorders like ischemic heart disease, myocardial infarction, arrhythmia etc. In this article we have emphasized the possibility of ocular involvement in OSA patients. Several studies have shown ocular associations like floppy eye lid syndrome, glaucoma, dry eye syndrome, papilledema, keratoconus, non-arteritic anterior ischemic optic neuropathy etc. Through this review, we would like to highlight the ophthalmological associations of OSA, their pathogenesis and outcome with the treatment of OSA.
Optimal design of anti-interrupted sampling repeater jamming waveform for missile-borne radar based on an improved genetic algorithm

The optimal design of transmitted waveforms to improve the performance of missile-borne radar in suppressing interrupted sampling repeater jamming (ISRJ) is studied here. The waveform diversity property requires that the waveform group has excellent orthogonality (good auto- and cross-correlation properties), which is an effective waveform optimisation design method for missile-borne radar electronic counter-countermeasures. The principle of orthogonal phase coding waveform against ISRJ is studied and the use of chaotic sequences is proposed to initialise the population, as well as a simulated annealing selection operator, which improves the convergence speed of the improved genetic algorithm (IGA) and enhances the global optimisation ability. The IGA improves the shortcomings of GA, that is, easily falling into a local optimum and slow search speed, and can realise a global search for longer orthogonal polyphase coding sequence sets. The simulation examples demonstrate the good jamming suppression performance of the proposed method.
A BL Lacertae Object at a Cosmic Age of 800 Myr

We report the discovery of the BL Lacertae object FIRST J233153.20+112952.11 at redshift >6 using near-infrared spectroscopy and broadband observations in the infrared, submillimeter, and radio wavelengths. The detection of the continuum break at ∼0.92 μm in the near-infrared spectrum of FIRST J233153.20+112952.11 provides an approximate redshift of 6.57, corresponding to an age of the universe of ∼800 Myr. The rest-frame UV/optical spectrum of FIRST J233153.20+112952.11 shows no emission lines detected with equivalent width >1.5 Å. The nondetection of the C iv λ1549 broad emission line constrains the luminosity of the accretion disk to be ≲1045 erg s−1, which corresponds to the radiatively inefficient accretion regime of BL Lacertae objects. The spectral index of the rest-frame UV/optical continuum, α ν,opt = 1.43 ± 0.23, is consistent with the expected spectral index of the synchrotron emission spectrum of the relativistic jet. The flat radio continuum (α ν,r ≈ 0) in a rest-frame frequency interval of 7–23 GHz is similar to that of the typical BL Lacertae objects and also consistent with originating from the synchrotron jet emission. The rest-frame UV/optical and radio fluxes of FIRST J233153.20+112952.11 show significant (15%–40%) variations. The shortest recorded rest-frame timescale of these variations is ∼8 days. Assuming the local scaling relation between the radio luminosity and black hole mass, the 5 GHz radio luminosity of FIRST J233153.20+112952.11, 1.6 × 1033 erg s−1 Hz−1, suggests a billion solar mass central supermassive black hole.
BEATING BROKE BY GETTING OUT? EXAMINING THE RELATIONSHIP BETWEEN PERSONAL DEBT AND COMMUNITY-OUTMIGRATION

Scholarship on young people’s geographical mobilities tells us that young adults move away from their childhood communities for a complex mix of economic “push-pull” reasons, including relationships, aspirations, attachments to place, identity, and belonging. In this abundant research, particularly that which focuses on youth outmigration from rural and peripheral communities, there is surprisingly little attention paid to an issue that is top-of-mind for many young adults today: personal debt. In this paper, we draw insights from extant literature on youth mobilities to make the case for a greater examination of the role of personal debt in young people’s migration decisions. We hypothesize that youth and debt increase a person’s likelihood of moving away from peripheral regions. We test this hypothesis using data from a 2019 survey of Atlantic Canadians and find some support for it, and some interesting nuance, suggesting that there is good reason to examine debt’s role in youth mobilities in greater detail.
Helheim Glacier diurnal velocity fluctuations driven by surface melt forcing

Abstract The influence of surface melt on the flow of Greenland's largest outlet glaciers remains poorly known and in situ observations are few. We use field observations to link surface meltwater forcing to glacier-wide diurnal velocity variations on East Greenland's Helheim Glacier over two summer melt seasons. We observe diurnal variations in glacier speed that peak ~6.5 h after daily maximum insolation and extend from the terminus region to the equilibrium line. Both the amplitude of the diurnal speed variation and its sensitivity to daily melt are largest at the glacier terminus and decrease up-glacier, suggesting that the magnitude of the response is controlled not only by melt input volume and temporal variability, but also by background effective pressure, which approaches zero at the terminus. Our results provide evidence that basal lubrication by meltwater drives diurnal velocity variations at Greenland's marine-terminating glaciers in a similar manner to alpine glaciers and Greenland's land-terminating outlet glaciers.
Contribution of the stringent response and Anr to anaerobic survival of Pseudomonads

In this study adaptation of Pseudomonas aeruginosa and Pseudomonas putida to changes in nutrient and oxygen availability was investigated. P. aeruginosa mutant strains unable to carry out the stringent response, mediating bacterial adaptation to growth-inhibiting stress conditions, were shown to have a severe growth defect in the absence of oxygen. This defect was to some extent abolished by rendering the strains unable to produce nitric oxide via denitrification, suggesting nitric oxide mediates the observed anaerobic growth defect. To determine the contribution of the stringent response to gene regulation under anaerobic conditions transcriptome analysis was carried out. This analysis did not directly indicate an accumulation of nitric oxide via denitrification in strains unable to carry out the stringent response, but revealed a deregulation of several genes involved in denitrification. The stringent response also is involved in transcriptional regulation of cellular processes contributing to P. aeruginosa pathogenesis, like alginate biosynthesis or type VI secretion. In the second part of this study contribution of the stringent response as well as oxygen-sensing transcriptional regulator Anr to adaptation of the obligate aerobic bacterium P. putida KT2440 to oxygen depletion was investigated. Anr-dependent gene regulation in P. putida was compared to that in P. aeruginosa PAO1 in order to define Anr-regulons in obligate aerobic compared to facultative anaerobic Pseudomonads. Additionally, gene clusters encoding various steps of the P. aeruginosa denitrification system were tested for their ability to promote P. putida anaerobic growth. PAO1 nitrate or nitrite and nitric oxide reductases did not enable KT2440 anaerobic growth but mediated a prolonged anaerobic survival. Transcriptome analysis with the respective strains revealed that expression of the denitrification genes might increase copper stress in P. putida.
DESENVOLVIMENTO PROFISSIONAL DE PROFESSORES DE COMPUTAÇÃO: UMA ANÁLISE DAS PRÁTICAS DOCENTES

Este artigo mostra como professores de computação não licenciados experienciaram o desenvolvimento profissional docente nos anos iniciais do exercício docente no curso de Licenciatura em Computação. A base metodológica para a produção deste artigo está fundamentada nas narrativas desses professores, nos referencias teóricos da sociologia fenomenológica de Alfred Schutz e nos modos de análise fenomenológica indicados por M. Bicudo. Trata-se de uma pesquisa qualitativa, empírica-compreensiva que tem como objetivo identificar, descrever e analisar experiências de docentes bacharéis ou tecnólogos, da área de computação, sobre a prática docente nos três primeiros anos de atuação como professor formador de futuros docentes de computação. A compreensão dessas práticas nos mostrou que os participantes compreendem o trabalho docente na dimensão do contexto de vida experienciado por eles, não se orientando em concepções teóricas e/ou pedagógicas.
Analisis Determinan Transfer Pricing pada Perusahaan Multinasional yang Terdaftar di Bursa Efek Indonesia

Penelitian ini bertujuan untuk menganalisis pengaruh Multinasionalitas, Tax Haven dan Thin Capitalization terhadap Transfer Pricing. Sampel dalam penelitian ini adalah seluruh perusahaan multinasional yang terdaftar di Bursa Efek Indonesia dari tahun 2016 hingga 2019 selain sektor keuangan, asuransi, pertambangan dan properti. Jumlah data yang sesuai dengan kriteria sampel adalah 260 data yang terdiri dari 65 perusahaan untuk tiap tahunnya. Metode analisis yang digunakan dalam mengolah data menggunakan analisis linier berganda. Penelitian ini menggunakan program Statistical Package for Social Sciences (SPSS). Hasil penelitian menunjukkan bahwa multinasionalitas dan tax haven tidak berpengaruh terhadap transfer pricing, dan thin capitalization berpengaruh positif terhadap transfer pricing.
Power law analysis for temperature dependence of magnetocrystalline anisotropy constants of Nd2Fe14B magnets

We perform phenomenological analysis of the temperature dependence of magnetocrystalline anisotropy (MA) in rare-earth magnets. We define the phenomenological power laws applicable to compound magnets using the Zener theory, and we apply these laws to study the magnetocrystalline anisotropy constants (MACs) of Nd2Fe14B magnets. The results indicate that the MACs closely obey the power law, and further, our analysis yields a better understanding of the temperature-dependent MA in rare-earth magnets. Furthermore, to examine the validity of the power law, we discuss the temperature dependence of the MACs in Dy2Fe14B and Y2Fe14B magnets as examples of cases wherein it is difficult to interpret the MA using the power law.
Three options are better than two: compensatory nature of different pollination modes in Salix caprea L.

Mixed pollination systems have been reported for many angiosperms. Here, we report on a dioecious willow, Salix caprea L. , which employs three pollination modes, namely pollination by wind, nocturnal moths, and diurnal bees. In four field populations of S. caprea in Germany, we addressed the following questions: (a) How are the pollination modes affected by local mate availability? (b) What is the contribution of each pollination mode to seed set? (c) How does flower opening time affect pollination? We compared seed set among seven pollination treatments (wind pollination, diurnal pollination, nocturnal pollination, natural pollination, apomictic reproduction, daytime/night-time artificial pollination). Pollen limitation was observed across populations. On the other hand, limitations in mate availability affected the pollination modes differently. Insect pollination outperformed wind pollination in situations where nearby males were few or all positioned in the same direction from the females. The contribution of nocturnal moths was lower than that of the other pollen vectors. However, moth pollination worked complementarily with bee pollination in compensating for the lack of wind pollination. Furthermore, we found that the onset of flower anthesis peaked at sunset, and that cold night temperatures had no negative effect on seed set or pollen viability. Thus, nocturnal anthesis and prior pollination by moths may minimize male fitness loss due to pollen collection and grooming by bees. We suggest that S. caprea maximizes its fitness by combining multiple pollination modes that work in different environmental conditions, while optimizing the anthesis so that more pollen would be delivered to stigmas.
Computer-aided Approaches to Support the Ethnopharmacological Importance of Dillenia pentagyna Roxb.: An In silico Study

Dillenia pentagyna Roxb. , a deciduous and medium sized tree, is an ethnobotanically important species of several Asian countries including Bangladesh, Srilanka, and India. Various parts of this endangered tree including leaf, bark, root etc. are used in folkloric medicine systems for a very long time. It is locally used in the treatment of pain, wound healing, diabetes, diarrhea and other disease states. Molecular docking is an important technique to validate the exerted pharmacological actions of a plant or specific phytoconstituents by assessing the binding affinity and interaction pattern between small molecules and particular target receptors. Thus, to justify the notable ethnobotanical importances of D. pentagyna, an in silico study was designed employing selected phytochemicals i.e. isorhamnetin, lupeol, quercetin, kaempferol, and betulin isolated from this plant based on previous literature searches. The molecular docking revealed strong binding affinities (-4.8 to -12.9 kcal/mol) with the respective target proteins: 2OYE, 6COX, 4YK5, 5ZHP, and 1A5H. Besides, in accordance with the Lipinski’s rules, all five selected compounds of D. pentagyna showed promising orally active drug-like characteristics. To recapitulate, the present study has been found parallel with the existing ethnobotanical significance of D. pentagyna as the source of pain, fever, thrombosis, and diarrhea management agent. Bangladesh Pharmaceutical Journal 24(2): 125-132, 2021
Identifying Public Policies to Promote Sustainable Building: A Proposal for Governmental Drivers Based on Stakeholder Perceptions

In recent years, research findings and pronouncements by international organisations have recognised the usefulness and timeliness of advancing public policies to promote sustainable building. However, in many parts of the world, governmental measures have limited their scope mainly to energy efficiency in housing use. In the same vein, some experiences in different countries have revealed the need to study further governmental or stimulation drivers that can boost sustainability in building, renovation, and dwellings. This paper aims to contribute to the design of public policies that promote sustainable building. Our paper seeks to identify specific drivers that can help governments boost sustainability in building, renovation, and dwellings through a multi-stakeholder survey. Our findings show the specific drivers to be of three types: fiscal, financial, and government interventions. It is the respondents’ opinion that public policies can help promote sustainable housing. Financial drivers are the most highly rated, followed by fiscal drivers and then government interventions.
Mereduksi Error Prediksi Pada Sistem Rekomendasi Menggunakan Pendekatan Colalborative Filtering Berbasis Model Matrix Factorization

Sistem pemberi rekomendasi banyak digunakan pada banyak website seperti marketplace, streaming film, e-commerce, dll untuk menghasilkan rekomendasi item yang sesuai dan disukai kepada setiap penggunanya. Pendekatan tradisional collaborative filtering berbasis memory saat ini masih banyak digunakan dalam sistem rekomendasi. Pendekatan ini bertumpu pada rating yang diberikan oleh pengguna terhadap suatu item sebagai pendekatan dasar untuk menghitung kesamaan respon pengguna terhadap produk untuk memberikan rekomendasi item, namum kelemahannya error prediksi yang dihasilkan saat memberikan rekomendasi item tinggi. Penelitian ini bertujuan untuk mereduksi error prediksi dari pendekatan collaborative filtering berbasis memory dengan menggunakan collaborative filtering berbasis model matrix factorization supaya dapat memperbaiki metode pada penelitian sebelumnya. Pendekatan collaborative filtering berbasis model matrix factorization merupakan salah satu pendekatan dalam sistem rekomendasi yang mampu mengurangi error prediksi untuk menghasilkan rekomendasi item yang akurat. Metode yang diusulkan telah dievaluasi sebanyak 5 kali iterasi menggunakan root mean squared error untuk mengukur error prediksi. Hasilnya, pendekatan collaborative filtering berbasis model matrix factorization yang kami usulkan mampu menghasilkan error prediksi terkecil sebesar 0,6814 sedangkan collaborative filtering berbasis memory menghasilkan error prediksi lebih besar yaitu 2,984.
Asymptotic sum-ruin probability for a bidimensional renewal risk model with subexponential claims

Abstract This article considers a bidimensional continuous-time renewal risk model with a constant interest force, in which the claim sizes from the same business line are dependent following a general dependence structure proposed by Ko and Tang (2008) and each pair of inter-arrival times of the two kinds of insurance claims are arbitrarily dependent. In the presence of subexponential claim sizes, the corresponding asymptotic formula for the finite-time sum-ruin probability is established.
Corrosion behaviour of galvanised steel in alkaline sodium chloride solution

ABSTRACT Corrosion performance of galvanised steels with coating thickness 5.6, 8.4 and 19.2 µm, named as T1, T2 and T3, respectively, was evaluated by immersion test and potentiodynamic polarisation in S1(0.025 M NaOH + 0.17 M NaCl) and S2(0.05 M NaOH + 0.34 M NaCl) solutions having pH 11.13 and 11.69, respectively. Corrosion rates calculated from immersion test were found to increase with the increase in coating thickness in both the solutions. For T1, T2 and T3, the corrosion rate decreased by 25.4%, 18.7% and 6.6%, respectively, in solution S2 compared to S1. FTIR studies of corrosion products showed that the absorption bands for ZnO at around 470 cm−1 and Zn5(OH)8Cl2.H2O (simonkolleite) at 902 cm−1was higher for samples exposed to S2 solution. The relative amount of the various phases in each solution was not affected by the coating thickness. Morphology of the immersion tested samples revealed that the corrosion product was thicker in S2 solution. Higher alkalinity and chloride concentration environment resulted in two passive regions in the potentiodynamic polarisation curves and decrease in passive current. Pitting under the corrosion product was observed at higher anodic potentials in the presence of higher alkalinity and chloride concentrations.
Seven new giant pill-millipede species and numerous new records of the genus Zoosphaerium from Madagascar (Diplopoda, Sphaerotheriida, Arthrosphaeridae)

Seven new species of the giant pill-millipede genus Zoosphaerium Pocock, 1895 are described from Madagascar: Z. nigrum sp. nov., Z. silens sp. nov., Z. ambatovaky sp. nov., Z. beanka sp. nov., Z. voahangy sp. nov., Z. masoala sp. nov. and Z. spinopiligerum sp. nov. All species are described based on drawings and scanning electron microscopy, while genetic barcoding of the COI gene was successful for six of the seven new species. Additional COI barcode information is provided for the first time for Z. album Wesener, 2009 and Z. libidinosum (de Saussure & Zehntner, 1897). Zoosphaerium nigrum sp. nov. and Z. silens sp. nov. belong to the Z. libidinosum species-group, Z. ambatovaky sp. nov. to the Z. coquerelianum species-group, Z. beanka sp. nov., Z. voahangy sp. nov. and Z. masoala sp. nov. to the Z. platylabum species-group and Z. spinopiligerum sp. nov. to the Z. piligerum species-group. Updated identification keys are provided for each species-group. Two western dry forest species, Z. silens sp. nov. and Z. voahangy sp. nov. are recorded from two localities, while the other five species are currently only known from their type localities. Of special conservation concern might be Z. ambatovaky sp. nov. from the lowland rainforest fragment of Ambatovaky, a nowadays isolated lowland rainforest, rapidly shrinking due to slash and burn agriculture. In addition to the new species, new locality data is provided for 11 species and numerous unidentifiable species of Zoosphaerium: Z. neptunus (Butler, 1872), Z. platylabum (de Saussure & Zehntner, 1902) and Z. piligerum (de Saussure & Zehntner, 1897) from the central eastern montane forests, as well as Z. ambrense Wesener, 2009, Z. aureum Wesener, 2009, Z. libidinosum, Z. corystoides Wesener, 2009, Z. discolor Wesener, 2009, Z. smaragdinum Wesener, 2009, Z. villosum Wesener & Sierwald, 2005 and Microsphaerotherium anjozorobe Wesener, 2009.