Miracle-dz/UniFAR-FTUs huggingface dataset:
Gold Nanoparticles Enhance the Ability of Radiotherapy to Induce Immunogenic Cell Death in Glioblastoma

Background Radiation therapy (RT) is commonly used to treat glioblastoma, but its immunomodulatory effect on tumors, through mechanisms such as immunogenic cell death (ICD), is relatively weak. Gold nanoparticles (AuNPs) have been suggested as potential radio-sensitizers, but it is unclear if they can enhance radiation-induced ICD. This study aimed to investigate the potential of AuNPs to improve the effectiveness of radiation-induced ICD. Methods G422 cells were treated with a combination of AuNPs and RT to induce cell death. Various assays were conducted to assess cell death, surface expression of CRT, and release of HMGB1 and ATP. In vitro co-culture experiments with bone marrow-derived dendritic cells (BMDCs) were performed to analyze the immunogenicity of dying cancer cells. Flow cytometry was used to measure the maturation rate of BMDCs. An in vivo mouse tumor prophylactic vaccination model was employed to assess immunogenicity. Results The study findings presented here confirm that the combination of radiotherapy (RT) with AuNPs can induce a stronger ICD effect on glioblastoma cells compared to using RT alone. Specifically, treatment with AuNPs combined with RT resulted in the emission of crucial damage-associated molecular patterns (DAMPs) such as CRT, HMGB1 (479.41±165.34pg/mL vs 216.04±178.16 pg/mL, *P<0.05) and ATP (The release of ATP in the AuNPs + RT group was 1.2 times higher than in the RT group, *P<0.05). The proportion of BMDC maturation rate was higher in the group treated with AuNPs and RT compared to the group treated with RT alone. (32.53±0.52% vs 25.03±0.28%,***P < 0.001). In the tumor vaccine experiment, dying tumor cells treated with AuNPs and RT effectively inhibited tumor growth in mice when exposed to living tumor cells. Conclusion These results indicate that AuNPs have the ability to enhance RT-induced ICD.
The combination of vaccines and adjuvants to prevent the occurrence of high incidence of infectious diseases in bovine

As the global population grows, the demand for beef and dairy products is also increasing. The cattle industry is facing tremendous pressures and challenges. The expanding cattle industry has led to an increased risk of disease in cattle. These diseases not only cause economic losses but also pose threats to public health and safety. Hence, ensuring the health of cattle is crucial. Vaccination is one of the most economical and effective methods of preventing bovine infectious diseases. However, there are fewer comprehensive reviews of bovine vaccines available. In addition, the variable nature of bovine infectious diseases will result in weakened or even ineffective immune protection from existing vaccines. This shows that it is crucial to improve overall awareness of bovine vaccines. Adjuvants, which are crucial constituents of vaccines, have a significant role in enhancing vaccine response. This review aims to present the latest advances in bovine vaccines mainly including types of bovine vaccines, current status of development of commonly used vaccines, and vaccine adjuvants. In addition, this review highlights the main challenges and outstanding problems of bovine vaccines and adjuvants in the field of research and applications. This review provides a theoretical and practical basis for the eradication of global bovine infectious diseases.
From Model to Everyday Practice: A Qualitative Observational Study of Daily Fact Team Board Meetings

Introduction: The Flexible Assertive Community Treatment (FACT) model has rapidly become a way of organising services for people with severe mental illness. FACT describes the integrated approach of interprofessional teams. Method: A qualitative study of interprofessional collaboration in three FACT teams was conducted. Thirty observations of the teams’ board meetings were conducted, and field notes were thematically analysed. Results: This study generated three themes in interprofessional collaboration in FACT teams. The first theme reflects the challenges of working in line with the model, the second suggests an unclear understanding of a shared caseload, and the third shows different approaches to working with a shared caseload. Discussion: The themes suggest that there is increased opportunity for the shared caseload in the FACT team board meeting. The findings reflect that there is a lack of either the resources necessary for working with a shared caseload or an understanding of the intention of a shared caseload. Conclusion: The potential of the shared caseload in FACT team board meetings are dependent on sufficient resources and a collective understanding of the FACT model and the shared caseload among professionals. Further research on how a shared caseload is experienced and facilitated in FACT teams can provide insight into their practices.
Tertiary Pacific Plate Motion Deduced from the Hawaiian-Emperor Chain

Nearly all linear island and seamount chains on the Pacific plate are parallel to small circles generated about either a Hawaiian pole at 72° N. , 83° W. or an Emperor pole at 17° N. , 107° W. The rates of rotation of the Pacific plate relative to the Hawaiian melting (hot) spot are calculated from age data from the Hawaiian-Emperor chain. Extrapolation of the known age progression along the Hawaiian chain yields a 27-m.y. estimate of the age of the Hawaiian-Emperor bend; however, recent radiometric ages from Koko seamount in the southern Emperor chain indicate that the Hawaiian-Emperor bend is 42 to 44 m.y. old. The Pacific plate apparently moved slowly, if at all, relative to the Hawaiian melting spot from about 20 to 42–44 m.y. ago. The rates of rotation calculated are 1.3° per m.y. about the Hawaiian pole (0 to 20–25 m.y.), The proposed rotational motion of the Pacific plate relative to the Hawaiian melting spot can be used to predict ages of seamounts and islands in other chains if the various melting spots are fixed with respect to one another. Almost all ages from other chains are consistent with the rotational model except for two K-Ar ages from the Austral chain. The proposed rotational motion of the Pacific plate can be used to reconstruct a paleomagnetic polar path of the Pacific plate if the melting spots are fixed with respect to the spin axis. The melting-spot polar path agrees well with the Late Cretaceous and limited Neogene paleomagnetic data. However, an extension of this polar path through the Late Cretaceous based on the Line Islands appears to be inconsistent with existing paleomagnetic data. The assumption that melting spots are fixed relative to the spin axis (and therefore the equator) can be tested by comparing the equatorial belt of high sedimentation with the sediment distribution predicted by the rotational-plate motion model. Almost every Deep Sea Drilling Project (DSDP) site presently located just north of the equator has its highest sedimentation rate at the time when the melting-spot motion model predicts that it was located at the equator. An equatorial sedimentation model adapted after Winterer (1972) is combined with the melting-spot motion model to generate a predicted isopach map of the post-middle Eocene equatorial sediments. The resulting isopach map is remarkably similar to the Ewing and others (1968) map of actual isopachs determined by seismic profiling. No data at present require motion of the Hawaiian melting spot relative to the spin axis. The tectonic histories of Japan and the Aleutians appear to reflect the proposed discontinuities of Pacific plate motion.
Where Does the Ground Water in Small Watersheds Come From?

Surface water and ground water watersheds commonly do not coincide. This condition is particularly relevant to understanding biogeochemical processes in small watersheds, where detailed accounting of water and solute fluxes commonly are done. Ground water watersheds are not as easily defined as surface watersheds because (1) they are not observable from land surface; (2) ground water flow systems of different magnitude can be superimposed on one another; and (3) ground water divides may move in response to dynamic recharge and discharge conditions. Field studies of relatively permeable terrain in Wisconsin, Minnesota, and Nebraska indicate that lakes and wetlands in small watersheds located near the lower end of extensive ground water flow systems receive ground water inflow from shallow flow systems that extend far beyond their surface watershed, and they may also receive ground water inflow from deeper regional flow systems that pass at depth beneath local flow systems. Field studies of mountainous terrain that have low‐permeability deposits in New Hampshire and Costa Rica also indicate that surface water bodies receive ground water inflow from sources beyond their local surface watersheds. Field studies of lakes and wetlands in North Dakota, Nebraska, and Germany indicate that ground water divides move in response to changing climate conditions, resulting in a variable source of ground water inflow to those surface water bodies.
Mycotoxins in food with particular reference to fumonisin B1 : their health impact on a Kranskop rural community, KwaZulu Natal.

The use of the multi-mycotoxin screen based on dialysis to analyze foods and feeds for mycotoxins, is well documented. This study investigated the possibility of incorporating FB I into the screen. Maize meal (25g) was spiked with AFB I , CPA, FB1, ST and ZEA and extraction was done using acetonitrile/4% potassium chloride (90:10 v/v). The recoveries of the mycotoxins were 77.4, 61.5, 97.4, 79.8 and 98% respectively on analysis by HPLC. Fumonisin B1 could not be completely incorporated into the screen due to its reaction with sodium hydrogen carbonate, which is a component in the method. Thus, FB I was determined in a separate portion of the extract. The high cost of FBI standards which are often of inferior purity necessitated that FB I standards be locally produced in the laboratory using Fusarium moniliforme MRC 826, a good producer of FB 1 . In this study, production of FB I was carried out using a stirred jar fermenter and patty cultures. The yields were 160mg/1 and 6mg/g of FB I for the two methods respectively. Methyl esterification of tricaballylic acid moieties of FB I was done for effective clean-up. This was achieved by derivatizing FBI, with diazomethane. It was found that other functional groups besides the tricaballylic acid moieties of FB I were undesirably methylated as well, which made cleanup by this method difficult as shown by electrospray mass spectrometric analysis. Attempts to de-methylate FBI methyl esters with esterase was not successful. Analysis of human faecal samples was carried out with the view of developing a short term marker for assessing human exposure to FB I . Faeces from rural (20) and urban (23) volunteers were analyzed by high performance liquid chromatography. The results showed that 35% of the rural samples and 9% of the urban volunteers had detectable amounts of FB I ranging from 0.600 to 19.56 mg/kg. There was a significant difference (p = 0.04) between the two population groups. A study was carried out to assess the occurrence of FBI in a rural area of Tugela valley in Kranskop magisterial district of KwaZulu Natal. A questionnaire was administered to gather information on the family health and nutrition. Raw (stored) and processed foods and faeces, were collected for analysis of FB1. A similar control study was carried out in the urban area of Durban Metro. Homes were mapped out using the GIS for easy follow-
Strong spatial variability in trace gasdynamics following experimental drought in a humid tropical forest

Soil moisture is a key driver of biogeochemical processes in terrestrial ecosystems, strongly affecting carbon (C) and nutrient availability as well as trace gas production and consumption in soils. Models predict increasing drought frequency in tropical forest ecosystems, which could feed back on future climate change directly via effects on trace gasdynamics and indirectly through changes in nutrient availability. We used throughfall exclusion shelters to determine effects of short‐term (3 month) drought on trace gas fluxes and nutrient availability in humid tropical forests in Puerto Rico. Exclusion and control plots were replicated within and across three topographic zones (ridge, slope, valley) to account for spatial heterogeneity typical of these ecosystems. Throughfall exclusion reduced soil moisture in all sites and lowered exchangeable phosphorus (P) on ridges and slopes. Drought decreased soil carbon dioxide (CO2) emissions by 30% in ridge sites and 28% in slope sites, and increased net methane (CH4) consumption by 480% in valley sites. Both valley and ridge sites became net nitrous oxide (N2O) sinks in response to soil drying. Emissions of CO2 and N2O, as well as CH4 consumption were positively related to exchangeable P and the nitrate:ammonium ratio. These findings suggest that drought has the potential to decrease net trace gas emissions from humid tropical forest soils. The differential response of trace gas emissions and nutrients from different topographic zones to drought underscores the complexity of biogeochemical cycling in these ecosystems and the importance of considering spatial heterogeneity when estimating whole system responses.
Modelling the effects of landscape fuel treatments on fire growth and behaviour in a Mediterranean landscape (eastern Spain)

The number of large fires increased in the 1970s in the Valencia region (eastern Spain), as in most northern Mediterranean countries, owing to the fuel accumulation that affected large areas as a consequence of an intensive land abandonment. The Ayora site (Valencia province) was affected by a large fire in July 1979. We parameterised the fire growth model FARSITE for the 1979 fire conditions using remote sensing-derived fuel cartography. We simulated different fuel scenarios to study the interactions between fuel spatial distribution and fire characteristics (area burned, rate of spread and fireline intensity). We then tested the effectiveness of several firebreak networks on fire spread control. Simulations showed that fire propagation and behaviour were greatly influenced by fuel spatial distribution. The fragmentation of large dense shrubland areas through the introduction of wooded patches strongly reduced fire size, generally slowing fire and limiting fireline intensity. Both the introduction of forest corridors connecting woodlands and the promotion of complex shapes for wooded patches decreased the area burned. Firebreak networks were always very effective in reducing fire size and their effect was enhanced in appropriate fuel-altered scenarios. Most firebreak alternatives, however, did not reduce either rate of fire spread or fireline intensity.
Association between Socioeconomic Factors, Food Insecurity, and Dietary Patterns of Adolescents: A Latent Class Analysis

Socioeconomic factors and food insecurity play a fundamental role in the food choices of adolescents, and in addition to influencing access to food, they also have significant effects on dietary patterns. The objectives of this study were to identify the dietary patterns of adolescents through the application of latent class analysis and to evaluate their association with socioeconomic variables and food insecurity. This cross-sectional study was conducted with adolescents aged between 11 and 17 years from public schools. Latent class analysis was used to identify the dietary patterns. Associations between socioeconomic factors, food insecurity and dietary patterns were assessed using multinomial logistic regression (odds ratio (OR); 95% confidence interval (CI)). Among the 1215 participants in the study, four dietary patterns were identified: “Mixed”, “Low consumption”, “Prudent” and “Diverse”. A “Diverse” dietary pattern was associated with a lower economic stratum (OR:2.02; CI:1.26–3.24). There was no association between food insecurity and identified dietary patterns. These results highlight the importance of promoting healthy eating in this age group at all socioeconomic levels, especially the lowest level.
Pre-calculation-based parallel filtered back projection for photoacoustic computed tomography

High-speed imaging capability is essential for photoacoustic computed tomography (PACT) to monitor biological dynamics. The filtered back-projection (FBP) algorithm is widely-used in PACT for image reconstruction owing to its high computational efficiency. To achieve high-speed imaging, several acceleration strategies based on the graphics processing units (GPUs) have been proposed to further increase the computational efficiency of the FBP algorithm. However, there are few acceleration strategies reported based on the multi-core central processing units (CPUs). Considering the fact that multi-core CPUs are much more accessible than high-performance GPUs, here we report a multi-core CPU-based framework for enhancing the computational efficiency of the FBP algorithm. In this framework, the highly-parallel back-projection part of the FBP algorithm is programed with C++ and implemented in parallel with multi-core CPUs. In addition, the pre-calculation strategy is applied in this framework to avoid unnecessary repetitive computations. The results show that implementing the back-projection part in parallel with C++ can reduce the image reconstruction time by a factor of 2.4 compared with the conventional implementation in which the FBP algorithm is fully programed with MATLAB and executed in parallel with parfor. By applying the pre-calculation, the image reconstruction time is further reduced by a factor of 2.2. Overall, the proposed framework increases the computational efficiency of the FBP algorithm by a factor of 5.5 and only takes 0.04 seconds to reconstruct an image with 512 × 512 pixels. This work is expected to promote the development of high-performance PACT systems that feature high imaging speed without GPUs.
Daily Life Methods in Adolescence and Emerging Adulthood Studies in Croatia, Serbia, and Slovenia: A Scoping Review

Daily life methods are a novel approach that grasps dynamics when studying various research topics. Although several international systematic reviews and meta-analyses demonstrate their popularity in studies of adolescence, it remains unclear whether daily life methods are also used to study development in different cultures. Therefore, the main aim of this review is to examine the frequency of use of daily life methods in studies of adolescence and emerging adulthood published in Croatian, Serbian, and Slovenian journals. Based on two inclusion criteria, with one being that a study should implement an experience sampling method or an ecological momentary assessment, and the other being that participants should be younger than 30 years, a search of five regional databases yielded only six research papers. The included studies implemented an experience sampling method, following recommendations from the literature. Thus, daily life methods do not yet seem to be recognized in Croatia, Serbia, and Slovenia, and efforts should be made to promote them to both researchers and practitioners. These methods can not only help us understand the differences between people, as well as the changes within a person, but they can also be the basis for tailored interventions, such as changing eating and sleeping habits.
Virgin compression of structured soils

This paper describes a study of the virgin compression behaviour of both naturally and artificially structured soils under one-dimensional compression or isotropic compression. It is proposed that during virgin compression, the additional voids ratio sustained by soil structure is inversely proportional to the current mean effective stress. The proposed formula has been verified for 20 different naturally and artificially structured soils, and it is seen that the proposal describes well the behaviour of all these soils. Finally, a general discussion on soil structure and its features is presented, and the proposed compression equation is extended to describe the compression of structured soil along a general stress path. Cet exposa est une etude du comportement d'une consolidation vierge sur des sols structuras de mani&gravere naturelle et artificielle, avec une consolidation unidimensionnelle on isotrope. Nous avancons que pendant la consolidation vierge, le taux de pore additionnel subi pa.
Aryloxyphosphazene-Modified and Graphite-Filled Epoxy Compositions with Reduced Flammability and Electrically Conductive Properties

A method has been developed for producing an epoxy composition based on a low-viscosity epoxy-resorcinol resin, a phosphazene-containing curing agent, isophoronediamine, and thermally expanded graphite as a filler. The degree of cure and the absence of side reactions during the curing process were confirmed using IR spectroscopy. The influence of the content of phosphazene-containing curing agent and filler on the physico-mechanical properties of the composition, its fire resistance, and antistatic properties were studied. Using the UL-94 HB horizontal burning test, it was found that the addition of 10 and 20 wt. % phosphazene-containing curing agent (relative to isophoronediamine) reduces the burning speed by 10 times compared to a sample without phosphazene. The addition of a filler to a composition containing phosphazene reduces the burning speed by 25 times compared to a composition without phosphazene and imparts antistatic properties to the epoxy composition, as evidenced by the specific volume electrical resistance of the order of 101 Ohm·m. Phosphazene-containing curing agent had no statistically significant effect on specific volume electrical resistivity (p > 0.05). Tests of physico-mechanical and adhesive properties (tensile strength, compressive strength, water absorption, water solubility, abrasion resistance, and adhesive strength) of filled epoxy compositions with 10 and 20 wt. % phosphazene-containing curing agent demonstrated that these properties met the requirements for floor coverings in construction and parts of electrical devices.
Genome-wide association mapping for yield-related traits in soybean (Glycine max) under well-watered and drought-stressed conditions

Soybean (Glycine max) productivity is significantly reduced by drought stress. Breeders are aiming to improve soybean grain yields both under well-watered (WW) and drought-stressed (DS) conditions, however, little is known about the genetic architecture of yield-related traits. Here, a panel of 188 soybean germplasm was used in a genome wide association study (GWAS) to identify single nucleotide polymorphism (SNP) markers linked to yield-related traits including pod number per plant (PN), biomass per plant (BM) and seed weight per plant (SW). The SLAF-seq genotyping was conducted on the population and three phenotype traits were examined in WW and DS conditions in four environments. Based on best linear unbiased prediction (BLUP) data and individual environmental analyses, 39 SNPs were significantly associated with three soybean traits under two conditions, which were tagged to 26 genomic regions by linkage disequilibrium (LD) analysis. Of these, six QTLs qPN-WW19.1, qPN-DS8.8, qBM-WW1, qBM-DS17.4, qSW-WW4 and qSW-DS8 were identified controlling PN, BM and SW of soybean. There were larger proportions of favorable haplotypes for locus qPN-WW19.1 and qSW-WW4 rather than qBM-WW1, qBM-DS17.4, qPN-DS8.8 and qSW-DS8 in both landraces and improved cultivars. In addition, several putative candidate genes such as Glyma.19G211300, Glyma.17G057100 and Glyma.04G124800, encoding E3 ubiquitin-protein ligase BAH1, WRKY transcription factor 11 and protein zinc induced facilitator-like 1, respectively, were predicted. We propose that the further exploration of these locus will facilitate accelerating breeding for high-yield soybean cultivars.