Miracle-dz/UniFAR-FTUs huggingface dataset:
Gastrin-Releasing Peptide Receptor Antagonist [68Ga]RM2 PET/CT for Staging of Pre-Treated, Metastasized Breast Cancer

Simple Summary [68Ga]RM2 positron emission tomography (PET)/computed tomography (CT) has shown to be a promising imaging method for primary breast cancer (BC) with positive estrogen receptor (ER) status, but it has not been tested for visualization of metastasized recurrent or progressive BC. The aim of this pilot study was to assess tumor visualization using [68Ga]RM2 PET/CT in patients with pre-treated ER-positive BC and suspected metastases. Eight female patients with initial ER-positive, pre-treated BC were included in this retrospective study. Strong RM2 binding was found in all metastatic lesions of six patients, whereas two patients were rated RM2-negative. Our data suggest that RM2 binding is maintained in the majority of patients with advanced disease stage of pre-treated ER-positive BC. Thus, [68Ga]RM2 PET/CT could support treatment decision in these patients, radiotherapy planning in oligometastatic patients or selection of patients for RM2 radioligand therapy. Abstract Background: Positron emission tomography (PET)/computed tomography (CT) using the gastrin-releasing peptide receptor antagonist [68Ga]RM2 has shown to be a promising imaging method for primary breast cancer (BC) with positive estrogen receptor (ER) status. This study assessed tumor visualization by [68Ga]RM2 PET/CT in patients with pre-treated ER-positive BC and suspected metastases. Methods: This retrospective pilot study included eight female patients with initial ER-positive, pre-treated BC who underwent [68Ga]RM2 PET/CT. Most of these patients (seven out of eight; 88%) were still being treated with or had received endocrine therapy. [68Ga]RM2 PET/CTs were visually analyzed by two nuclear medicine specialists in consensus. Tumor manifestations were rated qualitatively (i.e., RM2-positive or RM2-negative) and quantitatively using the maximum standardized uptake value (SUVmax). SUVmax values were compared between the two subgroups (RM2-positive vs. RM2-negative). Results: Strong RM2 binding was found in all metastatic lesions of six patients (75%), whereas tracer uptake in all metastases of two patients (25%) was rated negative. Mean SUVmax of RM2-positive metastases with the highest SUVmax per patient (in lymph node and bone metastases; 15.8 ± 15.1 range: 3.7–47.8) was higher than mean SUVmax of the RM2-negative metastases with the highest SUVmax per patient (in bone metastases; 1.6 ± 0.1, range 1.5–1.7). Conclusions: Our data suggest that RM2 binding is maintained in the majority of patients with advanced disease stage of pre-treated ER-positive BC. Thus, [68Ga]RM2 PET/CT could support treatment decision in these patients, radiotherapy planning in oligometastatic patients or selection of patients for RM2 radioligand therapy. Further studies with larger patient cohorts are warranted to confirm these findings.
Surface Characterisation of Dental Resin Composites Related to Conditioning and Finishing

Due to the little information related to surface processing and conditioning of resin matrix ceramic materials previous glazing, the main purpose of this in vitro study was to investigate the effect of different surface treatments on the surface morphology of different resin composite materials. Five types of resin composite CAD-CAM materials: a resin composite ceramic Vita Enamic (E) and four types of nanoparticle-filled resins, like Lava Ultimate (L), Cerasmart (C), Shofu HC (S), Hyramic (H) were taken into consideration. Specimens received the following surface treatment protocols: conventional polishing [p], polishing and glazing [pg], conditioning with CoJet [c], conditioning with CoJet and glazing [cg], sandblasting [s], sandblasting and glazing [sg], etching [e], etching and glazing [eg]. Surface roughness was analyzed for all samples and nanosurface topographic characterization was made by Atomic Force Microscopy. The highest roughness was registered for sandblasted surfaces [s], followed by tribochemical silica airborne particle abrasion [c], and etching [e]. A very strong correlated conditioning behavior of resin nanoceramic materials, like L, C and S samples was found. The microroughness decreased thus [s] > [c] > [e]. These are moderate correlated with H, and are moderate negative correlated to E, where e is more efficient. Three-dimensional images indicated visible grain boundaries after conditioning, for all materials. After polishing and glazing, surfaces became smoother. For all tested conditioning and finishing methods, surface roughness values were within clinically acceptable limits. Finishing by polishing was proved to be a good choice for all materials taken into consideration, polishing and glazing likewise, excepting Hyramic. For Enamic and Shofu HC sandblasting or tribochemical conditioning and glazing and for Hyramic polishing and glazing are not the best options, related to nanoroughness values. Referring to the nanosurface topography, for Enamic, Cerasmart and Hyramic, glazing would be the method of choice, associated with the adequate conditioning method for each material.
Lipofuscinosis ceroidea neuronal 6 (enfermedad Kufs tipo A): Reporte de caso en Colombia

I ntroductIon : Neuronal ceroid lipofuscinosis (CLN) is a group of neurodegenerative diseases generally with onset in childhood, characterized by intracellular accumulation of autofluorescent storage material. In the last decade, 14 forms of CLN have been identified with mutations in 13 genes (CLN1-CLN14), in CLN9 the gene has not yet been identified. Patients with mutations in the CLN6 gene located on chromosome 15q21-23 present three types of clinical variants: late childhood CLN6, presenting between 18 months to 8 years, the Kufs type A and Kufs type B variants of onset in adolescents and adults. c ase report : We present the case of a male patient with generalized epilepsy of onset in adulthood, who was admitted for evaluation the first time, with brain magnetic resonance imaging with mild cortical atrophy; he started at age 14 with slowly progressive cognitive deficit, without visual compromise; with subsequent genetic identification of a pathogenic variant in the CLN6 gene, jointly presenting the clinical variant Kufs type A of neuronal ceroid lipofuscinosis 6 (CLN6). d IscussIon : This is the first report of CLN6 with Kufs type A clinical variant in Colombia. With the advent of genetic techniques, specific diagnoses of CLN6 can be made, based on the clinical and suspected diagnoses; using non-invasive methods.
Women in construction: the untapped resource

Currently there are over 11 million women employed in the UK, accounting for 49.5% of the workforce. However, despite increases in the number of women employed in the construction industry over the past decade, they still constitute only 13% of the industry's workforce. This means that construction continues to be the most male dominated of all the major industrial groups. A review is presented of the literature relating to the current position of women in the construction industry. It identifies and examines the barriers preventing women's entry into the industry, the subsequent barriers faced by those working within the construction industry, and initiatives committed to promoting equality for women and men in construction. These barriers arise from a number of sources including: the construction industry's image; career knowledge amongst children and adults; selection criteria and male dominated courses; recruitment practices and procedures; sexist attitudes; male dominated culture; and the work environment.
EFFECTIVENESS OF VIDEO LESSONS USING MOBILE LEARNING FOR TECHNICAL TEACHERS

This research study is used to measure the effectiveness of mobile learning from the engineering teachers and impact on video lesson in the field of teaching and learning education system. The survey were conducted from engineering circuit branch teachers of affiliated colleges and deemed universities in Chennai, India. The survey used for video lesson to teachers and questionnaire is used to evaluate the effectiveness of mobile learning system. The80 engineering faculty were used from Electronics and Communication and Electrical and Electronics, and BioMedical Engineering teachers. The teachers are Master’s of Engineering and Technology, Doctor of Philosophy with their qualification, the video lesson used for this study is Electrocardiography, and the duration of the video lesson is 10 minutes. The smart phones, mobile phones and wireless devices tablet pc, personal digital assistants are used for this study. The video lesson can be transferred via Bluetooth technology in leisure hours.
Error feedback regulation for 1D anti-stable wave equation

This paper is concerned with the boundary error feedback regulation for a one-dimensional anti-stable wave equation with distributed disturbance generated by a finite-dimensional exogenous system. Transport equation and regulator equation are introduced first to deal with the anti-damping on boundary and the distributed disturbance of the original system. Then, the tracking error and its derivative are measured to design an observer for both exosystem and auxiliary partial differential equation (PDE) system to recover the state. After proving the well-posedness of the regulator equations, we propose an observer-based controller to regulate the tracking error to zero exponentially and keep the states of all the internal loop uniformly bounded. Finally, some numerical simulations are presented to validate the effectiveness of the proposed controller.
CTCF puts a new twist on UV damage and repair in skin cancer

ABSTRACT Somatic mutations in skin cancers are highly enriched at binding sites for CCCTC-binding factor (CTCF). We have discovered that CTCF binding alters the DNA structure to render it more susceptible to UV damage. Elevated UV damage formation at CTCF binding sites, in conjunction with subsequent repair inhibition, promotes UV mutagenesis.
A review of the research during 2010-2019 on evidence-based treatments for couple relationship distress.

The current article presents a review of the published research from 2010 to 2019 on the treatment of couple relationship distress; 37 studies met all criteria for inclusion. Behavioral Couple Therapy, Cognitive Behavioral Couple Therapy, Emotionally Focused Therapy, and Integrative Behavioral Couple Therapy meet criteria as "well-established" approaches, Insight-Oriented Couple Therapy is a "possibly efficacious" approach, and several other others are "experimental" treatments for treating couple relationship distress (Southam-Gerow & Prinstein, 2014). Furthermore, several less-intensive interventions-the Marriage Check-up, OurRelationship, and Hold Me Tight programs-have generated substantial support for their ability to improve relationships and are classified as "well-established" or "probably efficacious" interventions. We recommend that future research focus on expanding the reach of evidence-based interventions across a range of settings and populations, deepening our understanding of the mechanisms of change and underlying factors in the change process across approaches, and improving treatment success through treatment matching and progress monitoring.
Anisakis pegreffii Larvae in Sphyraena viridensis and Description of Granulomatous Lesions

Simple Summary Fish-borne zoonoses are caused by bacteria and parasites, while no viral fish-borne zoonoses have been reported, to date. Regarding zoonoses caused by parasites, Anisakiasis is one of the most important, with Anisakis simplex and Anisakis pegreffii agents in the central Mediterranean Sea. Humans can be infected by accidental ingestion of third-stage larvae in raw, undercooked or improperly processed fish or cephalopods. After ingestion, the larvae migrate from the gastrointestinal tract to gastrointestinal tissue, causing pain and, subsequently, inflammatory reaction leading to eosinophilic granuloma. This kind of reaction has not been described to date, in fish, and the aim of this study is to describe gastric wall lesions caused by A. pegreffii in Sphyraena viridensis and to compare them to those reported in humans, which appear macroscopically identical, albeit showing significant microscopic differences. Abstract The aim of the present study was to describe gastric granuloma caused by Anisakis pegreffii in Sphyraena viridensis caught in the central Mediterranean Sea. Sixty-eight S. viridensis specimens were collected from different fish markets on the east coast of Sicily. Coelomic organs were observed both macroscopically and with the aid of stereomicroscope. Parasite specimens and lesioned tissues were collected for identification, histological and molecular analyses. Twelve specimens (p = 17.6%) were positive for the presence of nematode larvae, morphologically identified as larvae of Anisakis sp. , with values of mean abundance and mean intensity of 0.9 and 4.8, respectively. One large female specimen showed massive parasite infection associated with nodular lesions of the gastric wall. By histology, several nematode larvae encysted through the gastric wall were found. The parasite bodies were surrounded by a granulomatous reaction made up of macrophages, epithelioid cells, some lymphocytes and an external connective sheet. Molecular analysis of 18S rRNA and cox2 genes from Anisakis sp. collected larvae, identified them as A. pegreffii. The lesions here described, though macroscopically superimposable on human eosinophilic granuloma, microscopically showed significant differences in the inflammatory cells involved and in the type of immune reaction.
Performance comparison of implantable piezoelectric energy harvesters

This paper presents experimental results that demonstrate energy generating performance of circular piezoelectric diaphragm harvesters for use in implantable medical devices. The piezoelectric energy generators are designed to transfer internal biomechanical forces into electrical energy that can be stored and used to power other in vivo devices. Such energy harvesters can eliminate complicated procedures for replacement of batteries in active implants by possibly increasing the longevity or capacity of batteries. Experimental results indicated that the PZT circular diaphragm harvesters generated enough power to meet requirements for specific implantable medical devices. It is also found that edge condition, thickness of bonding layer, and a degree of symmetry in fabrication for the unimorph circular diaphragms affect the energy generating performance significantly.
GPS Multipath Estimation with Improved SNR Adaptation Performance Utilizing Adaptive Filters

Global positioning system multipath estimation is important for both high precision positioning and reflection applications. The paper aims at proposing a method for estimating multipath parameters including carrier phases with good SNR adaptation performance utilizing adaptive filters. The method takes the signal after demodulation and spectrum dispreading for the desired signal. It is found to have a desired signal with relatively higher SNR so that the filtering performance is relatively better than previously proposed method; whats more, the method could estimate multipath code delay preferable to carrier phase ambiguity problem. Simulations validate the method can estimate multipath profile including amplitudes, code delay and carrier phases of direct path and multipath signals with small errors of 2% correct amplitude, smaller than one sampling interval code delay and 0.01 cycles carrier phase at 11dB SNR. The multipath mitigation performance of the method is better than that of narrow correlator.
Toward a Disease-Modifying Therapy of Alpha-Synucleinopathies: New Molecules and New Approaches Came into the Limelight

The accumulation of the various products of alpha-synuclein aggregation has been associated with the etiology and pathogenesis of several neurodegenerative conditions, including both familial and sporadic forms of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). It is now well established that the aggregation and spread of alpha-synuclein aggregation pathology activate numerous pathogenic mechanisms that contribute to neurodegeneration and, ultimately, to disease progression. Therefore, the development of a safe and effective disease-modifying therapy that limits or prevents the accumulation of the toxic intermediate products of alpha-synuclein aggregation and the spread of alpha-synuclein aggregation pathology could provide significant positive clinical outcomes in PD/DLB cohorts. It has been suggested that this goal can be achieved by reducing the intracellular and/or extracellular levels of monomeric and already aggregated alpha-synuclein. The principal aim of this review is to critically evaluate the potential of therapeutic strategies that target the post-transcriptional steps of alpha-synuclein production and immunotherapy-based approaches to alpha-synuclein degradation in PD/DLB patients. Strategies aimed at the downregulation of alpha-synuclein production are at an early preclinical stage of drug development and, although they have shown promise in animal models of alpha-synuclein aggregation, many limitations need to be resolved before in-human clinical trials can be seriously considered. In contrast, many strategies aimed at the degradation of alpha-synuclein using immunotherapeutic approaches are at a more advanced stage of development, with some in-human Phase II clinical trials currently in progress. Translational barriers for both strategies include the limitations of alpha-synuclein aggregation models, poor understanding of the therapeutic window for the alpha-synuclein knockdown, and variability in alpha-synuclein pathology across patient cohorts. Overcoming such barriers should be the main focus of further studies. However, it is already clear that these strategies do have the potential to achieve a disease-modifying effect in PD and DLB.
Applying benchmarking and data envelopment analysis (DEA) techniques to irrigation districts in Spain

In this research, the application of data envelopment analysis (DEA) is proposed as a methodology to overcome the problems related to the lack of methodology to assign the correct weightings for the calculation of indexes and to the subjectivity of the interpretations of results. DEA is a linear programming technique to determine the relative efficiencies of a company when the inputs and outputs of production units within the company are known, but the productive process itself is not. In this way, quantitative efficiencies and the weighting of any performance indicator can be assessed and compared, permitting managers to obtain a well‐defined performance ranking. This is especially important when managers dispose of a limited budget. The results of the application of this methodology to Andalusian irrigation districts (Spain) are presented and discussed here. This study was used to select the most representative irrigation districts in Andalusia which were then studied in greater depth by applying the performance indicators selected by IPTRID for use by the benchmarking international program. Copyright © 2004 John Wiley & Sons, Ltd.
On the Selection of Relevant Hardware Events for Explaining Execution Time Behavior

Estimating safe upper bounds on task execution times is required in the design of predictable real-time systems. When multi-core, instruction pipeline, branch prediction, or cache memory are in place, due to the considerable complexity static timing analysis faces, measurement-based timing analysis (MBTA) is a more tractable option. MBTA estimates upper bounds on execution times using data measured under the execution of representative scenarios. In this context, it is paramount understanding not only how the task execution time is affected during its execution but also what kind of interference the task is sensitive to. Events such as cache misses or pipeline stalls, for example, may lead to large variability in task execution times. Based on the fact that current platforms offer Performance Monitoring Units (PMUs) capable of counting hardware-level event occurrences, in this paper, we focus on the problem of selecting the events that have the most impact on task execution with the goal of enriching the collected information to better support MBTA. Unfortunately, PMU usually have a limited number of monitoring registers, making them unable to monitor all events at once. Our approach describes how to carry out the events selection even under this limitation. Results from our experiments, considering 15 different programs running on a Raspberry Pi, indicate that five selected events can explain the execution behavior of the programs with reasonable accuracy.
Understanding Healthcare Students’ Experiences of Racial Bias: A Narrative Review of the Role of Implicit Bias and Potential Interventions in Educational Settings

Implicit racial bias is a persistent and pervasive challenge within healthcare education and training settings. A recent systematic review reported that 84% of included studies (31 out of 37) showed evidence of slight to strong pro-white or light skin tone bias amongst healthcare students and professionals. However, there remains a need to improve understanding about its impact on healthcare students and how they can be better supported. This narrative review provides an overview of current evidence regarding the role of implicit racial bias within healthcare education, considering trends, factors that contribute to bias, and possible interventions. Current evidence suggests that biases held by students remain consistent and may increase during healthcare education. Sources that contribute to the formation and maintenance of implicit racial bias include peers, educators, the curriculum, and placements within healthcare settings. Experiences of implicit racial bias can lead to psychosomatic symptoms, high attrition rates, and reduced diversity within the healthcare workforce. Interventions to address implicit racial bias include an organizational commitment to reducing bias in hiring, retention, and promotion processes, and by addressing misrepresentation of race in the curriculum. We conclude that future research should identify, discuss, and critically reflect on how implicit racial biases are enacted and sustained through the hidden curriculum and can have detrimental consequences for racial and ethnic minority healthcare students.