Miracle-dz/UniFAR-FTUs huggingface dataset:
Beyond the Pain: A Systematic Narrative Review of the Latest Advancements in Fibromyalgia Treatment

Fibromyalgia is a complex chronic pain disorder that significantly impacts the quality of life of affected individuals. The etiology of fibromyalgia remains elusive, necessitating effective treatment options. This review aims to provide an overview of current treatment options for fibromyalgia and highlight recent updates in managing the condition. The methodology employed in this systematic review comprised the following key steps. We conducted a comprehensive search across various databases to identify pertinent studies published between 2000 and 2023. Inclusion criteria were defined to specifically target studies involving adult individuals diagnosed with fibromyalgia, with a focus on both pharmacological and non-pharmacological interventions for managing the condition. The review encompassed a range of study types, including randomized controlled trials, observational studies, and systematic reviews. To ensure the quality of the selected studies, we employed appropriate assessment tools, and data extraction and synthesis adhered to established guidelines. This rigorous approach allowed for a robust analysis of the literature on fibromyalgia management. In the course of our review, it became evident that a spectrum of treatment approaches holds significant promise in the management of fibromyalgia. Specifically, pharmacological interventions, including selective serotonin-norepinephrine reuptake inhibitors, anticonvulsants, cannabinoids, tropisetron, and sodium oxybate, have exhibited substantial potential in alleviating fibromyalgia symptoms. Concurrently, non-pharmacological strategies, such as cognitive-behavioral therapy, exercise regimens, and complementary and alternative therapies, have yielded positive outcomes in improving the condition's management. Recent developments in the field have introduced innovative pharmacological agents like milnacipran and pregabalin, in addition to non-pharmacological interventions like mindfulness-based stress reduction and aquatic exercise, expanding the array of options available to enhance fibromyalgia care and alleviating patient symptoms. Fibromyalgia necessitates a multidisciplinary approach to treatment, encompassing both pharmacological and non-pharmacological interventions. Recent updates in fibromyalgia management offer additional options to alleviate symptoms and improve the quality of life for individuals with fibromyalgia. Healthcare professionals should remain informed about these advancements to provide evidence-based care, addressing the complex symptoms associated with fibromyalgia and enhancing patient outcomes.
Coastal Wetlands: Function And Role In ReducingImpact Of Land-based Management

Coastal wetlands are among the most productive, valuable, and yet most threatened ecosystems in the world. They provide a variety of functions that reduce the impact of land-based management on the coastal zone such as slowing the fl ow of water from the mountains to the sea, trapping of sediments, and retaining or transforming nutrients. Numerous studies have reported that increased soil erosion and nutrient export from land-based management are threatening estuaries and coastal zones. Coastal wetlands are located at a critical interface between the terrestrial and marine environments and are ideally positioned to reduce impacts from land-based sources. There are various types of coastal wetlands including riparian wetlands, tidal freshwater marshes, tidal salt marshes, and mangroves. Some classifi cation systems also consider seagrass beds and coral reefs to be wetlands. Coastal wetland ecosystems vary in their ability to reduce impacts from land-based management in both space and time. These wetlands can retain, and transform, or sometimes even act as sources of nutrients and sediments. Some wetland types are more effective at sediment retention and others at nutrient retention. Watershed size, climate, and position of wetlands in a watershed are other important factors that determine the effectiveness of coastal wetlands in reducing the effects of land-based activities. Wetlands do not appear to be infi nite sinks for sediment or nutrients. Once critical sediment and nutrient loading thresholds have been crossed, coastal wetlands are subject to degradation and even loss. While many coastal nations have developed coastal-zone management policies and legislation, degradation and losses of coastal wetlands continue to occur due to altered hydrology, increased sediment and nutrient loading, urban development, agriculture, and aquaculture. While we have made signifi cant progress in our ability to restore and create tidal marshes and mangroves, other coastal systems such as seagrass beds and coral reefs appear to
Decoupling for Millimeter-Wave Array Antennas Using Near-Field Shrinking Dielectric Superstrate

A decoupling concept of near-field shrinking dielectric superstrate (NFSDS) is proposed for large-scale, wideband, and dual-polarized mm-wave arrays. An NFSDS with a thickness of 4 mm (<inline-formula> <tex-math notation="LaTeX">$0.32 \lambda _{0}$ </tex-math></inline-formula> at 24 GHz) is mounted seamlessly above the array, which shrinks the near field of the array elements to reduce the space wave coupling while slightly increasing the surface wave coupling of the arrays. By loading a superstrate with a certain thickness and low permittivity, the total coupling of the mm-wave arrays is reduced significantly. Periodic air holes are drilled through the superstrate to lower the NFSDS permittivity. An <inline-formula> <tex-math notation="LaTeX">$8\times8$ </tex-math></inline-formula> mm-wave array is simulated, fabricated, and measured to verify the proposed decoupling concept. The simulated and measured coupling of the mm-wave array is reduced from −17 dB to lower than −23.2 dB from 24−29.5 GHz and lower than −25 dB in most of the band, respectively. The radiation patterns of the array before and after decoupling almost keep unchanged. Moreover, the NFSDS can efficiently improve the array beam scanning capability. The measured results align well with the simulated.
River flood forecasting with a neural network model

A neural network model was developed to analyze and forecast the behavior of the river Tagliamento, in Italy, during heavy rain periods. The model makes use of distributed rainfall information coming from several rain gauges in the mountain district and predicts the water level of the river at the section closing the mountain district. The water level at the closing section in the hours preceding the event was used to characterize the behavior of the river system subject to the rainfall perturbation. Model predictions are very accurate (i.e., mean square error is less than 4%) when the model is used with a 1‐hour time horizon. Increasing the time horizon, thus making the model suitable for flood forecasting, decreases the accuracy of the model. A limiting time horizon is found corresponding to the minimum time lag between the water level at the closing section and the rainfall, which is characteristic of each flooding event and depends on the rainfall and on the state of saturation of the basin. Performance of the model remains satisfactory up to 5 hours. A model of this type using just rainfall and water level information does not appear to be capable of predicting beyond this time limit.
Entrepreneur, Entrepreneurship and Enterprise in Agricultural Mechanization Hire Service Enterprises in Developing Economies

The main aim of the research was to attempt to asses, appraise and diagnose entrepreneurs and entrepreneurship typologies in agricultural mechanization hire service enterprises (AMHSEs) in developing economies. The research identified 24 characteristics of AMHSE entrepreneurs and entrepreneurship, and these provided that AMHSEs commonly have a ‘mix’ of typologies of entrepreneurs and entrepreneurship. The research also found that there is a general tendency that according to enterprise size, the AMHSE will provide, for example, defined typologies of entrepreneurs and entrepreneurship along a continuum. However, enterprise-size is not the only ‘indicator’ of typology of entrepreneur and entrepreneurship of AMHSEs as also context, such as, for example, national and local economy, social norms, culture, and location (rural, peri-urban, urban). Overall, though, there was a distinct lack of documented evidence, literature and sources of secondary data and information, on AMHSE entrepreneurs and entrepreneurship and their typologies. This thus limiting research findings being inferred to a wider universe and also calling for further research to be conducted on the subject matter.
PENINGKATAN PELAKSANAAN KESELAMATAN PASIEN PERIOPERATIF PERAWAT PELAKSANA MELALUI PENGENDALIAN KEPALA RUANGAN DI RS X

Introduction the risk of errors in the perioperative period is very large so that patient safety should be supported and the team is obligated to cooperate in raising awareness toward the occurrence of the incident or event that is not expected. Head nurse control function ensure appropriate planning objectives accomplished. The purpose aims to know the effectiveness of the control function of the head nurse toward the implementation of perioperative patient safety. This research method research design using preexperiment with pretest-posttest design without control. The sample size of 75 nurses that involved in perioperative nursing service. The results data analysis using paired t test represent the effectiveness of the control function of the head nurse with p value = 0.0001 (CI = 120.79 – 127.01) and the improve of implementation of perioperative patient safety by nurses. The conclusion post intervention that indicates positive correlation with p value = 0.0001 (CI = 141.59 – 147.15). Suggestions this research recommends there should be monitoring and evaluation of implementation of the control head room and a development model that is more complete control
Growth Axis Somatostatin, Growth Hormone Receptor, and Insulin-like Growth Factor-1 Genes Express and Are Affected by the Injection of Exogenous Growth Hormone in Chinemys reevesii

In this study, to explore the effect of growth hormone changes on the related genes and regulatory roles of the turtle, PCR amplification, real-time fluorescence quantitative analysis, and enzyme cutting technology were used to clone and sequence the somatostatin (SS) gene, growth hormone receptor (GHR), and insulin-like growth factor-1 (IGF-I) sequence of Chinemys reevesii. The effects of human growth hormone on the mRNA expression of growth-axis-related genes SS, GHR, and IGF-1 in different sexes were observed. The study of the SS gene in turtles using real-time fluorescence quantitative PCR showed that the SS gene was mainly expressed in the nervous system and the digestive system, with the highest expression found in the brain, while the GHR gene and the IGF-I gene were expressed in all tissues of Chinemys reevesii. The SS gene was expressed in the brain, pituitary, liver, stomach, and intestine, with the highest expression in the brain and the lowest expression in the liver. Within 4 weeks of the injection of exogenous growth hormone, the expression level of the SS gene in the brain of both sexes first increased and then decreased, showing a parabolic trend, and the expression level of the experimental group was lower than that of the control group. After the injection of growth hormone (GH), the expression of the GHR gene in the liver of both sexes showed a significant increase in the first week, decreasing to the control group level in the second week, and then gradually increasing. Finally, a significant level of difference in the expression of the GHR gene was reached at 3 and 4 weeks. In terms of the IGF-I gene, the changing trend of the expression level in the liver was the same as that of the GHR gene. After the injection of exogenous growth hormone, although the expression of the SS gene increased the inhibition of the secretion of the GHR gene by the Reeves’ turtle, exogenous growth hormone could replace the synthesis of GH and GHR, accelerating the growth of the turtle. The experiments showed that the injection of recombinant human growth hormone affects the expression of SS, GHR, and IGF-1 genes, and promotes the growth of the Reeves’ turtle.
A Note on Redesign Material Substitution and Topology Optimization in a Lightweight Robotic Gripper

The gripper is required because it is the portion of the robot that makes direct contact with the object being grasped. It should weigh as little as possible without compromising functionality or its performance. This study aims to reconsider the construction of a lightweight robotic gripper by modifying the gripper's materials and topology. Using the finite element (FE) method, several types of gripper materials were evaluated for static stress. On the basis of the results of the FE analysis, the optimal material candidate was chosen using the weighted objective method. Using the Fusion 360 software, the topology of the selected material was then optimized in an effort to achieve the 40% weight reduction’s objective. In addition, the suggested optimized geometry is then fine-tuned so that it can be manufactured as efficiently as possible. The final step in the validation of the robotic gripper's design was stress static analysis. The revised gripper design has a mass of 0.08 kg, a reduction of 94% from the original mass, and a safety factor of 3.67%, which satisfies the desired level of performance for the robotic gripper. Utilizing different materials and optimizing the gripper's topology can significantly reduce the overall mass of a robotic gripper.
The fate of subducted sediments: A case for backarc intrusion and underplating

Subduction of oceanic and continental sediments into the mantle is fundamental to the geochemical evolution of Earth. Using thermal-mechanical models, we examine the dynam- ics of sediments that are subducted below continental lithosphere. Owing to their low density relative to the mantle, model sediments detach from the subducting plate at ~100 km depth. With ongoing subduction, a subhorizontal sediment plume develops and intrudes the conti- nental lithosphere. This occurs for a wide range of sediment densities and rheologies, suggest- ing that sediment detachment may be important for regions where the subducted sediment thickness is larger than ~350 m. In these areas, a reservoir of sediments may be found in the shallow backarc mantle. In contrast to models of sediment transport to the deep mantle, the detachment model predicts chemical and mechanical interactions between the sediments and backarc mantle lithosphere and a shallow sediment source for arc and backarc magmas.
Hematologic and lymphatic system toxicities associated with immune checkpoint inhibitors: a real-world study

Introduction: Immune checkpoint inhibitors (ICIs) exert antitumor responses in many types of cancer but may also induce serious or fatal toxicities that affect all organ systems, including the hematologic and lymphatic systems. However, the risk of hematologic and lymphatic system toxicities following different ICI treatments remains unknown. This study aimed to describe the hematologic and lymphatic system toxicities associated with different ICI regimens and the impact of combining ICIs with anti-vascular endothelial growth factor drugs using the United States Food and Drug Administration Adverse Event Reporting System pharmacovigilance database. Methods: The reporting odds ratio (ROR) and information component (IC) indices were used to identify disproportionate reporting of ICI-associated hematologic and lymphatic adverse events (AEs). Results: We extracted 10,971 ICI-associated hematologic and lymphatic AEs from 35,417,155 reports. These AEs were more frequently reported in female patients (ROR: 1.04 95% confidence interval [CI]: 1.01–1.07) and younger patients (ROR: 1.05 95% CI: 1.01–1.09). The disseminated intravascular coagulation fatality rate (63.97%) was the highest among the reported preferred terms, despite its low incidence (3.32%). The time to onset of ICI-related hematologic and lymphatic AEs was relatively short, with 77.44% reported within 3 months. Disproportionate analysis showed that most ICIs were associated with significant overreporting of hematologic and lymphatic AEs (IC025: 0.34 and ROR025: 2.10). Hematologic and lymphatic system AEs were more frequently reported in patients treated with anti-programmed cell death protein 1/programmed cell death ligand 1 monotherapy than in those treated with anti-cytotoxic T-lymphocyte-associated protein 4 monotherapy (ROR: 1.54, 95% CI: 1.38–1.71), with atezolizumab showing the strongest signal (ROR025: 4.19, IC025: 1.00). In patients receiving combined treatment, ICIs plus bevacizumab exerted a higher disproportion signal than monotherapy (ROR: 161, 95% CI: 1.75–1.88). Discussion: The spectrum of hematologic and lymphatic AEs differed according to the ICI regimen. Early recognition and management of ICI-related hematologic and lymphatic AEs are vital in clinical practice.
Housing inequality in relation to housing tenure: Evidence from Ho Chi Minh City

Unfair distribution of social resources, including valuable assets such as housing, leads to inequality and threatens the sustainable development of countries. This phenomenon is a hot issue, attracting the attention of many researchers worldwide. Ho Chi Minh City is considered one of the economic-financial centers of Vietnam, with a high average annual GDP growth rate, rapid urbanization, and the flow of migrant workers to live and work has increased rapidly in recent years. Although many achievements are based on outstanding developments, Ho Chi Minh city has faced many difficulties in housing policy due to the limited urban land fund, colossal population, and housing prices many times higher than the residents’ income. It is shown that there are difficulties in access to affordable housing in Ho Chi Minh City, especially for the population's low- and middle-income segments. This creates inequality and considerable pressure on housing development policy in urban areas. The article uses OLS regression to analyze issues related to housing inequality in Ho Chi Minh City in the relaion to living space and homeownership, then gives some implications for housing policy toward improving the quality of living standards in terms of residential conditions. Research data is taken from a survey of 700 households in Ho Chi Minh City conducted by the author in 2020. The results show that household income, working time, age, education, household size, and a household with small business activity at home affect the household living space area. In addition, these factors have different impacts on families with housing tenure. The author believes that in the future, the government should focus on improving education, providing stable jobs, and planning suitable housing places to ensure equitable distribution of social resources, including housing.
A method for imaging water transport in soil–snow systems with neutron radiography

Liquid water at the ground–snow interface is thought to play a crucial role in the release of glide-snow avalanches, which can be massive and threaten infrastructure in alpine regions. Several mechanisms have been postulated to explain the formation of this interfacial water. However, these mechanisms remain poorly understood, in part because suitable measurement techniques are lacking. Here, we demonstrate the use of neutron radiography for imaging water transport in soil–snow systems. Columns of sand, gravel and snow were used to simulate the capillary forces of the soil–vegetation–snow layering found in nature. The columns were connected to a water reservoir to maintain a constant-pressure boundary condition and placed in a climatic chamber within the neutron beam. We show that neutron radiography is capable of measuring changes in the optical density distribution (related to liquid water content) within all three layers of the model system. Results suggest that a porous interface between the sand and snow may induce the formation of a water layer in the basal snowpack. Improved understanding of the water transport in soil–snow systems should lead to better prediction of glide-snow avalanche release and could also benefit other fields such as snow hydrology.
Spike Timing Dependent Gradient for Direct Training of Fast and Efficient Binarized Spiking Neural Networks

Spiking neural networks (SNNs) are well-suited for neuromorphic hardware due to their biological plausibility and energy efficiency. These networks utilize sparse, asynchronous spikes for communication and can be binarized. However, the training of such networks presents several challenges due to their non-differentiable activation function and binarized inter-layer data movement. The well-established backpropagation through time (BPTT) algorithm used to train SNNs encounters notable difficulties because of its substantial memory consumption and extensive computational demands. These limitations restrict its practical utility in real-world scenarios. Therefore, effective techniques are required to train such networks efficiently while preserving accuracy. In this paper, we propose Binarized Spike Timing Dependent Gradient (BSTDG), a novel method that utilizes presynaptic and postsynaptic timings to bypass the non-differentiable gradient and the need of BPTT. Additionally, we employ binarized weights with a threshold training strategy to enhance energy savings and performance. Moreover, we exploit latency/temporal-based coding and the Integrate-and-Fire (IF) model to achieve significant computational advantages. We evaluate the proposed method on Caltech101 Face/Motorcycle, MNIST, Fashion-MNIST, and Spiking Heidelberg Digits. The results demonstrate that the accuracy attained surpasses that of existing BSNNs and single-spike networks under the same structure. Furthermore, the proposed model achieves up to 30 $\times \times \times $ speedup in inference and effectively reduces the number of spikes emitted in the hidden layer by 50% compared to previous works.
Signaling Pathways Controlling Axonal Wrapping in Drosophila

The rapid transmission of action potentials is an important ability that enables efficient communication within the nervous system. Glial cells influence conduction velocity along axons by regulating the radial axonal diameter, providing electrical insulation as well as affecting the distribution of voltage-gated ion channels. Differentiation of these wrapping glial cells requires a complex set of neuron–glia interactions involving three basic mechanistic features. The glia must recognize the axon, grow around it, and eventually arrest its growth to form single or multiple axon wraps. This likely depends on the integration of numerous evolutionary conserved signaling and adhesion systems. Here, we summarize the mechanisms and underlying signaling pathways that control glial wrapping in Drosophila and compare those to the mechanisms that control glial differentiation in mammals. This analysis shows that Drosophila is a beneficial model to study the development of even complex structures like myelin.