Miracle-dz/UniFAR-FTUs huggingface dataset:
Microsoft Word-HSI-Publication 2011 (new).docx

In recent years, a novel hypothesis in cancer therapeutics has been proposed. It states that abnormal expression of aurora kinases (AURK) contributes to neoplastic transformation and carcinogenesis, and that inhibitors of AURK can provide a valuable tool in the chemotherapeutic arsenal. As such, AURK inhibitors have become a hot item on Big Pharma’s list. So far, preclinical and clinical data point towards the inhibitors’ activity against solid tumors, with mainly cytostatic effects on cancer stabilization. There is great hope in the eventual implementation of these drugs in clinical practice.
Analysis of Bistatic and Monostatic Sea Clutter

In this work, we analyze the sea clutter data collected simultaneously by the bistatic and monostatic nodes of a S-band netted radar system. The analyzed radar system is the NetRad, developed by the University College London (UCL) and the datasets were collected with four different out-of-plane geometries. The aim of the analysis is to compare statistically the behavior of the bistatic and monostatic sea clutter for different geometries. In particular, we focus on the sea spikes, whose presence increases the probability of false alarm of the radar detector. The statistical analysis is carried out by comparing the empirical distribution of sea clutter data with some known heavy-tailed distributions and by studying the behavior of three statistical parameters, the kurtosis the Weibull and K+Noise shape parameter. An algorithm that separates the sea spikes from the Bragg background is implemented, in order to study in-depth the sea spikes statistics. To this aim, we examine the empirical distribution of the spike duration and of the interval between two subsequent spikes. The results of our analyses show that spikiness is higher for low values of the bistatic angle and that bistatic data are sometimes less spiky than monostatic ones only for horizontal polarization.
Department of Economics- FEA/USP

The main objective of this work is to investigate the present and long-term spatial distribution of the logistics sector in Brazil. In order to do so, this study seeks to answer the following questions: i) how is the logistics sector organized in Brazil? that is, is there evidence of logistics clusters? ; ii) what is the longterm perspective of this organization? The Logistics Potential Mapping Model (MapLog), inspired by Krugman's Core-Periphery Model, will serve as an analytical tool to verify the long-term spatialization of the logistics sector. The results point to a change within five decades (2015-2065) of the locational pattern of the logistics sector focused on industry but not for the logistics sector focused on agriculture.
Etude de la dispersion horizontale en zone littorale sous l'effet de la circulation tridimensionnelle forcée par les vagues - Application à la baie de Saint Jean de Luz - Ciboure et au littoral de Guéthary-Bidart

Ce travail de these apporte des elements en vue d’une meilleure comprehension de la circulation et des processus de dispersion associes aux vagues a proximite des plages. Un outil de modelisation numerique operationnelle a ete developpe, fonde sur le modele spectral d’etat de mer WAVEWATCH III R et le modele hydrodynamique 3-D MOHID Water. Le code MOHID a ete etendu a l’approche glm2z pour la representation des interactions 3-D vagues-courant. Les developpements theoriques permettant l’obtention des equations glm2z sont rassembles et detailles dans ce travail. L’implementation de ces equations au sein de l’outil de modelisation est exposee. L’outil construit est valide sur deux cas academiques, ou est mise en evidence sa capacite a reproduire la solution fournie par des modeles numeriques de reference. Par la suite, la modelisation est combinee a des observations in situ pour etudier deux sites de la cote Sud Atlantique francaise. Ces sites correspondent a des configurations littorales complexes, associant une influence significative des vagues et une stratification haline notable de la colonne d’eau. La confrontation des resultats du calcul 3-D aux mesures fournit des resultats encourageants et apporte des elements utiles pour la comprehension de la variabilite des courants et des profils de salinite observes. Une baie estuarienne semi-fermee est tout d’abord etudiee. La modelisation y suggere un effet significatif des vagues sur la dispersion des panaches estuariens, susceptible d’impacter la vidange globale de la baie a l’echelle d’un episode de precipitations. Le second site d’application permet l’etude de la circulation intense induite par les vagues au-dessus d’un systeme barre/chenal, ainsi que la dispersion des eaux douces introduites par une riviere dans la zone de deferlement. Ce travail fournit finalement un outil de modelisation 3-D pour l’etude de la circulation et du transport sous l’effet de l’ensemble des forcages littoraux.
HUOM! Tämä on alkuperäisen artikkelin rinnakkaistallenne. Rinnakkaistallenne saattaa

The paper presents the ongoing defining of a measurement framework with an intellectual capital (IC) perspective for dynamic distributed software development (DDSD). The topic examines building the capabilities, evaluating the efficiency and scaling up the performance of globally distributed software development teams in environments that demand high operational excellence and innovation performance. The University of Tampere, Haaga-Helia University of Applied Sciences and the University of Helsinki are collaborating on a research project, DD-SCALE (2014-2016), with four industrial software companies working at the forefront of their industry. The objectives of the project are to investigate and develop measurement solutions, tools and work practices for managing and evaluating DDSD work. The project addresses the challenge of harnessing human and social capital assets for scaling high-performing teams to fit with highperforming organizations. The research questions of the paper are: 1) What are the applicable dimensions, in the context of IC, of a comprehensive and scalable measurement framework for DDSD? 2) What are the relevant indicators for measuring the performance of DDSD? 3) How can a framework, its dimensions and indicators be effectively implemented in practice? The chosen research approach is design and action research that has a qualitative emphasis. The theory perspectives of IC, performance management and distributed software development are applied. First, literature reviews were conducted. Next, data was collected from the participating companies by the means of interviews and workshops. The collected data was then analyzed by conducting a qualitative content analysis. The findings were then utilized for constructing the dimensions of the framework, identifying the measurement indicators, and designing prototypes for the implementation of the framework. Thus far, the results include: 1) the human, structural and relational capital dimensions of the measurement framework that can be combined for examining companies on individual, team and organizational levels; 2) a categorized set of candidates for indicators; and 3) an outline of the construction as well as preliminary prototypes for implementing the framework. The next steps of the research will include the advancement of the construction of the framework and prototypes. Examples of applicable deliverables derived from the construction will include a mobile barometer tool and an impact analysis solution for assessing DDSD work. The results will contribute to the management and development of work practices and help to realize the implementation of high performing software research and development (RD) operations within a dynamically and globally distributed setting.
Congenital nephrotic syndrome in IL7R a - SCID: A rare feature of maternofetal graft-versus-host disease

Biallelic mutations in IL7R, encoding the IL-7 receptor a-chain, typically present as T BþNKþ severe combined immunodeficiency (SCID) owing to the protein’s role in early T-lymphocyte development, accounting for 5% to 10% of SCID cases with variation by population. Rarely, hypomorphic IL7R mutations may cause Omenn’s syndrome (OS), manifesting as erythroderma, lymphadenopathy, hepatosplenomegaly, and raised IgE, generated by autologous autoreactive T lymphocytes. An important differential diagnosis is engraftment of maternal T lymphocytes causing graft-versus-host disease (maternofetal engraftment [MFE]). One case of nephrotic syndrome associated with OS has been previously described. Nephrotic syndrome, comprising of edema, hypoproteinemia, heavy proteinuria, and hyperlipidemia, may arise from inherited defects in glomerular filtration or acquired from immune-mediated glomerular damage, and is treated with intravenous albumin transfusion and immunosuppression. We report a case of an infant with compound heterozygous IL7R mutations, presenting with congenital nephrotic syndrome and subsequently demonstrating features of MFE. Data were collected retrospectively from medical records, with written consent from the family. The patient was born at term by forceps delivery to healthy nonconsanguineous parents of Portuguese descent, without antecedent family history suggesting primary immunodeficiency. At age 2 weeks, he presented with generalized edema. Investigations demonstrated heavy glomerular proteinuria (>400 mg/m/d) with albuminuria (194 mg/L), hypoproteinemia (34.2 g/L), and normal lipid profile (Table I), initially improving with regular albumin transfusion. Cytomegalovirus DNA was not detected in blood or urine. He subsequently developed bloodstained stools: colonoscopy demonstrated mild hemorrhagic colitis, which resolved with introduction of a milk-free formula. He was commenced on thyroxine for hypothyroidism (Table I).
Primera cita de Megaselia scalaris (Loew, 1866), (Diptera: Phoridae) en Apis mellifera iberiensis

En este trabajo se denuncia por primera vez en Espan~a la presencia de estadios larvarios y adultos de la mosca necro´faga Megaselia scalaris (Loew, 1866), (Diptera: Phoridae) en cada´veres de abeja meli´fera (Apis mellifera iberiensis) y se dan datos sobre su biologi´a.
Laser à fibre multimode avec remise en forme de faisceau par diffusion Brillouin stimulée

De nombreux efforts sont actuellement portes sur le developpement de sources laser a fibre optique, qui ont des applications dans une variete de domaines scientifiques et industriels. Les proprietes intrinseques de la fibre dopee sont favorables a l'obtention de fortes puissances moyennes, grâce a une excellente capacite de dissipation thermique. Cependant, le confinement de la lumiere dans le coeur de la fibre et les grandes longueurs d'interaction sont a l'origine d'effets non lineaires, comme la diffusion Brillouin stimulee dans le cas d'une source de faible largeur spectrale. L'objectif de ce travail de these est de developper une source laser fibree de forte energie alliant bonne qualite spatiale et finesse spectrale, dans le but de repondre a un besoin de LIDAR a detection coherente. L'approche suivie consiste a separer l'obtention de l'energie de celle de la qualite de faisceau. Avec une chaine amplificatrice dont le dernier etage est une fibre multimode co-dopee Erbium-Ytterbium, des impulsions laser a la longueur d'onde de 1,5 μm avec une energie superieure a 1 mJ ont ete obtenues. Le tres large coeur de la fibre evite l'apparition de l'effet Brillouin, mais le profil transverse du faisceau est fortement multimode. Pour retrouver une bonne qualite de faisceau, un etage de remise en forme du profil est mis en place, mettant a profit la propriete de nettoyage de faisceau par effet Brillouin dans une fibre multimode agradient d'indice. Par ailleurs, un schema original d'amplification Brillouin est propose et valide experimentalement, permettant de conserver la largeur spectrale de la source.
Pre-exposure prophylaxis (PrEP) for HIV prevention

KEY POINTS Pre-exposure prophylaxis (PrEP) is a daily course of antiretroviral drugs (ARVs) taken by HIV-negative people to protect themselves from infection. Evidence shows that, when taken consistently and correctly, PrEP reduces the chances of HIV infection to near-zero. PrEP is cost effective, and there is growing demand for it from people at higher risk of HIV infection, but the scale and coverage currently remains limited. PrEP does not protect against other STIs so needs to be delivered as part of a comprehensive package of HIV/STI prevention services. PrEP’s effectiveness decreases rapidly if not taken regularly as prescribed, so addressing the barriers preventing adherence is key to success.
Pre-exposure prophylaxis ( PrEP ) for HIV prevention

KEY POINTS Pre-exposure prophylaxis (PrEP) is a daily course of antiretroviral drugs (ARVs) taken by HIV-negative people to protect themselves from infection. Evidence shows that, when taken consistently and correctly, PrEP reduces the chances of HIV infection to near-zero. PrEP is cost effective, and there is growing demand for it from people at higher risk of HIV infection, but the scale and coverage currently remains limited. PrEP does not protect against other STIs so needs to be delivered as part of a comprehensive package of HIV/STI prevention services. PrEP’s effectiveness decreases rapidly if not taken regularly as prescribed, so addressing the barriers preventing adherence is key to success.
PINK GLOVES STILL GIVE BLACK EYES Exploring ‘Alternative’ Femininity in Women’s Combat Sports

Ple a s e no t e: Ch a n g e s m a d e a s a r e s ul t of p u blishing p roc e s s e s s uc h a s copy-e di ting, for m a t ting a n d p a g e n u m b e r s m ay no t b e r eflec t e d in t his ve r sion. For t h e d efini tive ve r sion of t his p u blica tion, ple a s e r ef e r to t h e p u blish e d sou rc e. You a r e a dvise d to cons ul t t h e p u blish e r’s ve r sion if you wish to ci t e t his p a p er.
Counterfactual Representations for Intersectional Fair Ranking in Recruitment

Fairness interventions require access to sensitive attributes of candidates applying for a job, which might not be available due to limitations imposed by data protection laws. In this work we propose using a pre-processing technique to create counterfactual representations of the candidates that lead to a more diverse ranking with respect to intersectional groups. To be compliant with data protection laws we propose to train a model on the fairer representations and apply the model at inference time without having access to the sensitive attributes of the candidates. In experiments on the BIOS dataset, we find this approach can improve the diversity of recommendations at top-ranked positions without harming performance.
Quinazoline-based analogue of adenine as an antiDOTe against MLLr cells: synthesis, inhibition assays and docking studies

Background. Post-translational modifications of histones constitute a dynamic process impacting gene expression. A well-studied modification is lysine methylation. Among the lysine histone methyltransferases, DOT1L is implicated in various diseases making it a very interesting target for drug discovery. DOT1L has two substrates, the SAM cofactor that gives the methyl group and the lysine H3K79 substrate. Results. Using molecular docking we explored new bisubstrate analogues to enlarge the chemical landscape of DOT1L inhibitors. We showed that quinazoline can successfully replace the adenine in the design of bisubstrate inhibitors of DOT1L, showing a similar activity compared to the adenine derivative but with a diminished cytotoxicity. Conclusions. The docking model is validated together as the use of quinazoline in the design of bisubstrate inhibitors.
Meat Science and Nutrition

The consumer’s profile has changed, and in recent years, there has been a greater concern for the nutritional quality of meat, especially in relation to fat that compose it. The meat fat composition can contribute to the onset of cardiovascular disease. On the other hand, fat is an essential component in the human diet, as well as providing energy; it contains essential fatty acids (FAs) that must be present in food. The meat nutritional properties are largely related to its fat content and fatty acid composition. In addition, fat gives flavor to food, helps in the absorption of vitamins, and plays an important role in the immune response, for humans, and animals. The fat nutritional and sensory quality in meat that is determined by the fatty acid composition can affect the degree of fat saturation, the storage stability, and flavor. There are several factors that can influence the fatty acid composition, such as animals’ species, breed, sex, and diet, causing various changes in carcass, as well as in tissues and chemical meat composition.
Identi�cation, Characterization and Site-Saturation Mutagenesis of a Thermostable ω -Transaminase From Chloro�exi Bacterium

In present study, we have mined a ω-transaminase (ω-TA) from Chloroflexi bacterium from genome database by using an ω-TA sequence ATA117 Arrmut11 from Arthrobacter sp . KNK168 and an amine transaminase from Aspergillus terreus as templates in a BLASTP search and motif sequence alignment. The protein sequence of the ω-TA from C. bacterium shows 38% sequence identity to ATA117 Arrmut11. The gene sequence of the ω-TA was inserted into pRSF-Duet1 and functionally expressed in E. coli BL21(DE3). Results showed that the recombinant ω-TA has a specific activity of 1.19 U/mg at pH 8.5, 40 °C. The substrate acceptability test showed that ω-TA has significant reactivity to aromatic amino donors and amino receptors. More importantly, the ω-TA also exhibited a good affinity towards some cyclic substrates such as 1-Boc-3-piperidone. The homology model of the ω-TA was built by Discovery Studio and docking was performed to describe the relative activity towards some substrates. The ω-TA was evolved by site-saturation mutagenesis and found that the Q192G mutant increased the activity to the (R)-α-methylbenzylamine (MBA) by around seven-fold. The Q192G mutant was then used to convert two cyclic ketones, N -Boc-3-pyrrolidinone and N -Boc-3-aminopiperidine, and the conversions were both improved compared to the parental ω-TA. Graphical Abstract
Innovation Resistance Barriers to Online Purchase Intention: The Mediating Role of Perceived Price and Perceived Enjoyment

Purpose – The goal of capturing their ideal selves affects every step that individuals will take throughout their lives. This aim has made cosmetic product usage a necessity for modern people. For this reason, cosmetic products have a crucial role in transforming consumers into the person they want to be. The research provides data that supports this role of individuals in the process of reaching the ideal self. Today
Are Risk Aversion and Impatience Related to Cognitive Ability ?

Are Risk Aversion and Impatience Related to Cognitive Ability? Is the way that people make risky choices, or tradeoffs over time, related to cognitive ability? This paper investigates whether there is a link between cognitive ability, risk aversion, and impatience, using a representative sample of the population and incentive compatible measures. We conduct choice experiments measuring risk aversion, and impatience over an annual time horizon, for a randomly drawn sample of roughly 1,000 German adults. Subjects also take part in two different tests of cognitive ability, which correspond to sub-modules of one of the most widely used IQ tests. Interviews are conducted in subjects' own homes. We find that lower cognitive ability is associated with greater risk aversion, and more pronounced impatience. These relationships are significant, and robust to controlling for personal characteristics, educational attainment, income, and measures of credit constraints. We perform a series of additional robustness checks, which help rule out other possible confounds. JEL Classification: C93, D01, D80, D90, J24, J62
Advances in weed management for organic cereal production in southeast Australia.

Organic cereal production in southeast Australia is challenging for producers due to a range of e of influences such as weeds and low soil available phosphorus. Two experiments were conducted on a certified organic property at Berrigan NSW during 2001-2003 to investigate ‘within crop’ weed management and forage crop management for weed control. Sowing later using a short season wheat cultivar did not affect yield and reduced (P<0.05) levels of annual ryegrass (Lolium rigidum Gaud.). Incorporating a forage crop into the rotation prior to sowing a cereal resulted in improved (P<0.05) weed management for the cereal crop, in comparison to retaining annual pasture. There were no differences between forage treatments in weed management in the following wheat crop. Where forage was cut for silage and then grazed, grain yield was higher (P<0.05) than where forage was only grazed or cut for silage, or where annual pasture was retained.
Lab-on-a-chip Technologies Enabled by Surface Acoustic Waves

During the past two decades, microuidics has emerged as an important platform in chemistry, biology, and medicine. The introduction of “labon-a-chip” (i.e., small-sized analytical devices) has spurred steadily increasing interest and research efforts in the microuidics discipline (upon which lab-on-a-chip devices are based). The promise of such lab-on-a-chip devices is grounded in the advantages of microuidics relative to traditional laboratory techniques used in chemistry and biomedicine: system miniaturization, automation, low cost, reduced reagent and sample consumption, rapid turnaround time, and precise microenvironment control. With an aim
ARBITRALNOŚĆ KULTUROWA SZKOŁY A ZACHOWANIA TOŻSAMOŚCIOWE DZIECI-UCZNIÓW

Introduction: The school as a cultural institution provides ready-made models of identity in direct and subliminal cultural messages, confronting the child-student on a daily basis with the necessity to (successfully) cope with the (mis)comprehension of meanings produced by the school culture. Research Aim: In article the author makes an attempt to (re)cognize how the narratives conducted and/or imposed by the emerging school culture determine the (un)conscious acquisition by children of meanings that describe their school reality and build their identity as learners. The study was embedded in the theoretical framework of the reconstructed psychocultural concept of school culture according to Bruner and the theory of cultural reproduction developed by Bourdieu. Method: Narrative interviews conducted with ten-year-old children from the risk group, fourth-grade students, are research material that has been analyzed and interpreted with the use of the hermeneutic-phenomenological method of coding. Results: The results of the research relate to the perception of school by children who have crossed the second educational threshold in terms of school rules and norms. The research focuses on the process of implementing the child into the role of a student, indicating the oppressive nature of the school culture. Conclusions: In the conclusions, the author tries to draw attention tothe hidden beliefs about students who become a material, an object or a product of the school (culture) activity and contrast them with Korczak’s idea of openness and sensitivity to the child’s potential.