Miracle-dz/UniFAR-FTUs huggingface dataset:
Disparities in Vision Impairment and Eye Diseases among Early Late-Life Women: The Study of Women’s Health Across the Nation, Michigan Site

ABSTRACT Objective: To quantify the burden of vision impairment (VI) and ocular conditions among early late-life women. Methods: Women (n = 254, mean age 66.0 years) participated in a comprehensive vision assessment. Visual acuity (VA) and ocular disorders (diabetic retinopathy, macular degeneration, hypertensive retinopathy, glaucoma and cataracts) were defined clinically. Race, economic strain and education were self-reported. Results: The prevalence of presenting VI (VA 20/40 or worse) was 11.0% and 75% of that was correctable (best-corrected VI 2.8%). Black women and those with greater economic strain or less education had a higher prevalence of presenting VI. These disparities were no longer present after considering best-corrected VI. Ocular disease prevalence ranged from 3.3% (age-related macular degeneration) to 30.2% (hypertensive retinopathy), but most participants were unaware of their ocular diagnosis. Conclusion: The discordance of presenting versus best-corrected VI and lack of knowledge of ocular conditions suggests a need for increased vision services. Access to optimal vision correction may attenuate differences across sociodemographic groups.
Hydrogen-Bonds Mediated Nanomedicine: Design, Synthesis and Applications.

Among the various challenges in medicine, diagnosis, complete cure and healing of cancers remain difficult given the heterogeneity and complexity of such disease. Differing from conventional platforms with often unsatisfactory theranostic capabilities, the contribution of supramolecular interactions, such as hydrogen-bonds (H-bonds), to cancer nanotheranostics opens new perspectives for the design of biomedical materials, exhibiting remarkable properties and easier processability. Thanks to their dynamic characteristics, a feature generally observed for non-covalent interactions, H-bonding (macro)molecules can be used as supramolecular motifs for yielding drug- and diagnostic carriers that possess attractive features, arising from the combination of assembled nanoplatforms and the responsiveness of H-bonds. Thus H-bonded nanomedicine provides a rich toolbox that is useful to fulfill biomedical needs with unique advantages in early-stage diagnosis and therapy, demonstrating the promising potential in clinical translations and applications. We here summarize the design and synthetic routes towards H-bonded nanomedicines, focus on the growing understanding of the structure-function relationship for efficient cancer treatment. We propose a guidance for designing new H-bonded intelligent theranostic agents, to inspire more successful explorations of cancer nanotheranostics and finally to promote potential clinical translations. This article is protected by copyright. All rights reserved.
Patients with Congestive Cardiac Failure Referred to Specialist Palliative Care

Background Congestive cardiac failure is a chronic, progressive condition with a significant symptom burden. There is limited data available regarding the palliative care requirements of the heart failure population. Aims To characterise patients with a primary diagnosis of congestive cardiac failure referred to a specialist palliative care (SPC) service in Ireland. Methods A retrospective chart review of patients with congestive cardiac failure admitted to the specialist palliative care unit or reviewed by the community palliative care team over 2 years was carried out, utilising a data collection template. Results 57 patient charts were included. 54% (n = 31) were female. Mean age was 81 [60 - 97] years. GP’s referred 42% (n = 24), Cardiologists 39% (n = 22) and other hospital consultants 19% (n = 11). The commonest symptom reported was dyspnoea (n = 47). Time from referral to death ranged from less than one month (n =22) to greater than one year (n = 3). 14 patients were discharged from the service due to lack of SPC needs. Place of death was distributed between home, hospice, nursing home and acute hospital. Conclusions Patients with congestive cardiac failure experience high symptom burden. More than 50% of patients that died while receiving SPC input had been referred less than 1 month prior, while almost a quarter of all referrals resulted in patient discharge. This highlights the importance of further education regarding indication for specialist palliative care referral and the benefits of early referral in this patient cohort when appropriate.
The sentience shift in animal research

One of the primary concerns in animal research is ensuring the welfare of laboratory animals. Modern views on animal welfare emphasize the role of animal sentience, i.e. the capacity to experience subjective states such as pleasure or suffering, as a central component of welfare. The increasing official recognition of animal sentience has had large effects on laboratory animal research. The Cambridge Declaration on Consciousness (Low et al., University of Cambridge, 2012) marked an official scientific recognition of the presence of sentience in mammals, birds, and cephalopods. Animal sentience has furthermore been recognized in legislation in the European Union, UK, New Zealand and parts of Australia, with discussions underway in other parts of the world to follow suit. In this paper, we analyze this shift towards recognition of sentience in the regulation and practice in the treatment of laboratory animals and its effects on animal welfare and use.
How stories and narrative move the heart—literally

In June 2019, at the University of Birmingham in England, psychologist Damian Cruse invited 27 young adults to come to the lab, on separate occasions, and listen to the same clips from an audiobook of Jules Verne’s 20,000 Leagues Under the Sea. Sitting alone, each donned headphones and electrocardiogram (EKG) equipment while a voice with a British accent recounted tales of a mysterious monster taking down ships. When researchers later compared volunteers’ heart rates, a curious phenomenon emerged: The heart rates of nearly two-thirds of the participants rose and fell together as the story progressed (1). “It’s not that the beats align synchronously, but rather the heart rate fluctuations go up and down in unison,” explains Lucas Parra, a biomedical engineer at City College of New York, and co-senior author on the study. Research has already shown that brain activity can synchronize when listeners pay attention to the same video or story (2). Now, Parra and others are finding that the heart, too, offers insight into who is really paying attention to a story. Potential applications are myriad. With heart rate recordings from smart watches, a webinar host may one day learn whether the audience is engaged, or a doctor could offer a family insight into whether a loved one will recover consciousness. But the technology is new and researchers are still grappling with how to harness heart rate data responsibly, even as they continue to explore why stories move hearts in synchrony in the first place.
Cyclic di-GMP Regulates the Type III Secretion System and Virulence in Bordetella bronchiseptica

The second messenger cyclic di-GMP (c-di-GMP) is a ubiquitous molecule in bacteria that regulates diverse phenotypes. Among them, motility and biofilm formation are the most studied. ABSTRACT The second messenger cyclic di-GMP (c-di-GMP) is a ubiquitous molecule in bacteria that regulates diverse phenotypes. Among them, motility and biofilm formation are the most studied. Furthermore, c-di-GMP has been suggested to regulate virulence factors, making it important for pathogenesis. Previously, we reported that c-di-GMP regulates biofilm formation and swimming motility in Bordetella bronchiseptica. Here, we present a multi-omics approach for the study of B. bronchiseptica strains expressing different cytoplasmic c-di-GMP levels, including transcriptome sequencing (RNA-seq) and shotgun proteomics with label-free quantification. We detected 64 proteins significantly up- or downregulated in either low or high c-di-GMP levels and 358 genes differentially expressed between strains with high c-di-GMP levels and the wild-type strain. Among them, we found genes for stress-related proteins, genes for nitrogen metabolism enzymes, phage-related genes, and virulence factor genes. Interestingly, we observed that a virulence factor like the type III secretion system (TTSS) was regulated by c-di-GMP. B. bronchiseptica with high c-di-GMP levels showed significantly lower levels of TTSS components like Bsp22, BopN, and Bcr4. These findings were confirmed by independent methods, such as quantitative reverse transcription-PCR (q-RT-PCR) and Western blotting. Higher intracellular levels of c-di-GMP correlated with an impaired capacity to induce cytotoxicity in a eukaryotic cell in vitro and with attenuated virulence in a murine model. This work presents data that support the role that the second messenger c-di-GMP plays in the pathogenesis of Bordetella.
Natural plant products as effective alternatives to synthetic chemicals for postharvest fruit storage management

Abstract Fruits contain enormous source of vitamins that provides energy to the human body. These are also affluent in essential and vital vitamins, minerals, fiber, and health-promoting components, which has led to an increase in fruit consumption in recent years. Though fruit consumption has expanded considerably in recent years, the use of synthetic chemicals to ripen or store fruits has been steadily increasing, resulting in postharvest deterioration. Alternatives to synthetic chemicals should be considered to control this problem. Instead of utilizing synthetic chemicals, this study suggests using natural plant products to control postharvest decay. The aim of this study indicates how natural plant products can be useful and effective to eliminate postharvest diseases rather than using synthetic chemicals. Several electronic databases were investigated as information sources, including Google Scholar, PubMed, Web of Science, Scopus, ScienceDirect, SpringerLink, Semantic Scholar, MEDLINE, and CNKI Scholar. The current review focused on the postharvest of fruits has become more and more necessary because of these vast demands of fruits. Pathogen-induced diseases are the main component and so the vast portion of fruits get wasted after harvest. Besides, it may occur harmful during harvesting and subsequent handling, storage, and marketing and after consumer purchasing and also causes for numerous endogenous and exogenous diseases via activating ROS, oxidative stress, lipid peroxidation, etc. However, pathogenicity can be halted by using postharvest originating natural fruits containing bioactive elements that may be responsible for the management of nutritional deficiency, inflammation, cancer, and so on. However, issues arising during the postharvest diseases must be controlled and resolved before releasing the horticultural commodities for commercialization. Therefore, the control of postharvest pathogens still depends on the use of synthetic fungicides; however, due to the problem of the development of the fungicide-resistant strains there is a good demand of public to eradicate the use of pesticides with the arrival of numerous diseases that are expanded in their intensity by the specific chemical product. By using of the organic or natural products for controlling postharvest diseases of fruits has become a mandatory step to take. In addition, antimicrobial packaging may have a greater impact on long-term food security by lowering the risk of pathogenicity and increasing the longevity of fruit shelf life. Taken together, natural chemicals as acetaldehyde, hexanal, eugenol, linalool, jasmonates, glucosinolates, essential oils, and many plant bioactive are reported for combating of the postharvest illnesses and guide to way of storage of fruits in this review.
Landmark Discoveries and Recent Advances in Type IV Pilus Research

Type IV pili (T4P) are retractable multifunctional nanofibers present on the surface of numerous bacterial and archaeal species. Their importance to microbiology is difficult to overstate. SUMMARY Type IV pili (T4P) are retractable multifunctional nanofibers present on the surface of numerous bacterial and archaeal species. Their importance to microbiology is difficult to overstate. The scientific journey leading to our current understanding of T4P structure and function has included many innovative research milestones. Although multiple T4P reviews over the years have emphasized recent advances, we find that current reports often omit many of the landmark discoveries in this field. Here, we attempt to highlight chronologically the most important work on T4P, from the discovery of pili to the application of sophisticated contemporary methods, which has brought us to our current state of knowledge. As there remains much to learn about the complex machine that assembles and retracts T4P, we hope that this review will increase the interest of current researchers and inspire innovative progress.
Brain stimulation competes with ongoing oscillations for control of spike timing in the primate brain

Transcranial alternating current stimulation (tACS) is a popular method for modulating brain activity noninvasively. In particular, tACS is often used as a targeted intervention that enhances a neural oscillation at a specific frequency to affect a particular behavior. However, these interventions often yield highly variable results. Here, we provide a potential explanation for this variability: tACS competes with the brain’s ongoing oscillations. Using neural recordings from alert nonhuman primates, we find that when neural firing is independent of ongoing brain oscillations, tACS readily entrains spiking activity, but when neurons are strongly entrained to ongoing oscillations, tACS often causes a decrease in entrainment instead. Consequently, tACS can yield categorically different results on neural activity, even when the stimulation protocol is fixed. Mathematical analysis suggests that this competition is likely to occur under many experimental conditions. Attempting to impose an external rhythm on the brain may therefore often yield precisely the opposite effect.
Association between social deprivation and incidence of first seizures and epilepsy: A prospective population‐based cohort

Epidemiologic studies have investigated whether social deprivation is associated with a higher incidence of epilepsy, and results are conflicting, especially in children. The mechanisms underlying a potential association are unclear. This study examines whether there is an association between social deprivation and the incidence of first seizures (unprovoked and provoked) and new diagnosis of epilepsy by comparing incidence across an area‐level measure of deprivation in a population‐based cohort.
Critical roles for EGFR and EGFR–HER2 clusters in EGF binding of SW620 human carcinoma cells

Epidermal growth factor (EGF) signalling regulates normal epithelial and other cell growth, with EGF receptor (EGFR) overexpression reported in many cancers. However, the role of EGFR clusters in cancer and their dependence on EGF binding is unclear. We present novel single-molecule total internal reflection fluorescence microscopy of (i) EGF and EGFR in living cancer cells, (ii) the action of anti-cancer drugs that separately target EGFR and human EGFR2 (HER2) on these cells and (iii) EGFR–HER2 interactions. We selected human epithelial SW620 carcinoma cells for their low level of native EGFR expression, for stable transfection with fluorescent protein labelled EGFR, and imaged these using single-molecule localization microscopy to quantify receptor architectures and dynamics upon EGF binding. Prior to EGF binding, we observe pre-formed EGFR clusters. Unexpectedly, clusters likely contain both EGFR and HER2, consistent with co-diffusion of EGFR and HER2 observed in a different model CHO-K1 cell line, whose stoichiometry increases following EGF binding. We observe a mean EGFR : EGF stoichiometry of approximately 4 : 1 for plasma membrane-colocalized EGFR–EGF that we can explain using novel time-dependent kinetics modelling, indicating preferential ligand binding to monomers. Our results may inform future cancer drug developments.
Disassociation of social and sexual partner relationships in a gibbon population with stable one‐male two‐female groups

Adult males living in a one‐male multi‐female social group are expected to try to monopolize copulations with resident females to increase reproductive fitness. Gibbons have traditionally been described as living in monogamous groups, with the sole resident adult male assumed to sire all of the group's offspring. Here, we used microsatellite analyses and behavioral observations to examine rates of extra‐group paternity (EGP) over 16 years in a population of crested gibbons (Nomascus concolor) that form stable and long‐term one‐male two‐female social units. Forty percent of offspring (N = 14) were sired by extra‐group males. To understand this high level of EGP, we tested whether inbreeding avoidance was related to EGP. Females who engaged in EGP did not show larger pairwise relatedness with their resident male compared to females who did not engage in EGP. Nevertheless, the standardized heterozygosity of EGP offspring was significantly higher than for offspring sired by the group's resident male. These results provide partial support for the inbreeding avoidance hypothesis. It appears that resident male crested gibbons are unable to monopolize resident females' matings. Our results indicate that long‐term social partners are often distinct from sexual partners in this population. Clearly, the breeding system of crested gibbons is more flexible than previously thought, indicating a need for integrating long‐term behavioral data and genetic research to re‐evaluate gibbon social and sexual relationships derived from concepts of monogamy and pair‐bonding.
Introduction of "Internet of Things" its Application and Challenges

In recent years, the term "Internet of Things" has spread rapidly we're entering a new era of computing technology that many are calling the Internet of Things (IoT). Machine to machine, machine to infrastructure, machine to environment, the Internet of Everything, the Internet of Intelligent Things, intelligent systems call it what you want, but it's happening, and its potential is huge. We see the IoT as billions of smart, connected "things" (a sort of "universal global neural network" in the cloud) that will encompass every aspect of our lives, and its foundation is the intelligence that embedded processing provides. The IoT is comprised of smart machines interacting and communicating with other machines, objects, environments and infrastructures. As a result, huge volumes of data are being generated, and that data is being processed into useful actions that can "command and control" things to make our lives much easier and saferand to reduce our impact on the environment. The creativity of this new era is boundless, with amazing potential to improve our lives. Now consider that IoT represents the next evolution of the Internet, taking a huge leap in its ability to gather, analyze, and distribute data that we can turn into information, knowledge, and, ultimately, wisdom. In this context, IoT becomes immensely important.
Structural numerical analysis of a three fingers prosthetic hand prototype

In spite of the importance of the finite element method analysis in the mechanical design, there are a few research works in the prosthetic hands design area that use this tool. This work uses the finite element method to perform a structural analysis of a prosthetic hand prototype during the cylindrical and tip grasp. Through geometric relations, a set of equations was developed in order to define the position of the prosthesis elements from the position of the actuator. The loads in the numerical analysis were calculated by modeling a static analysis, in which the forces that the fingers of the prosthesis can exert at the tip were obtained. The results are presented in a graphic form showing the load of the fingertip as function of the position of the actuator and the maximum force that can be exerted. It is shown as well the field stress present in the mechanism of the hand simulator for the most critical position and the field stress of the prosthesis prototype. Both parameters were calculated with the use of ANSYS Workbench 2.0 ® Key words: Upper limb prosthesis, prehensile force, finite element method, four-bar linkage, structural analysis.
Design For All: the role of Design as Anomaly for a Changing Paradigma

Design today is a research discipline seeking design as a mediation factor that create and manage compromise rather than conflict. To contrast this view, this paper argues that “Anomaly” is desirable and necessary in order to accommodate the most daring and thought innovative ideas and approaches expressed in the design thinking process. Design for All is a radically innovative way of thinking, looking at, and acting the design process. We are not standard, and design often doesn’t know it. DfA expresses the critical issues of a design project in the most enabling way, answering to the abilities, necessities and aspirations of all people and people behaviours involved in the design process. DfA is well-suited to keep pace with a fast changing environment because as an approach it is constantly evolving and updating itself: thus, it answers to social complexity and human diversity and creates mutual benefits for entrepreneurs, users and public administrators. Approaching Human Diversity means capturing a larger market. The 'All' of DfA are the individuals who wish to use that which is designed (product, space, service, etc.) and that the decision makers want to implement. Desire is the only proper element of discrimination and one of the factors that makes DfA a successful approach, even in mature markets. In this context we introduced Design for All as a way to embrace the randomness generated through disruption, and suggest that the creative professional has to acquire the capability to navigate rather than oppose the uncertainty.
Phoresy Involving Insects as Riders or Rides: Life History, Embarkation, and Disembarkation

Abstract The ability to disperse is vital for all organisms, but especially for those whose habitats deteriorate, necessitating relocation to better feeding or breeding sites. Phoresy is assisted dispersal in which one organism uses another as its vehicle. In this review, phoresy will be largely restricted to cases wherein the rider is not parasitic on the vehicular stage used for dispersal, and in which insects are riders or rides. Phoresy occurs in organisms with limited mobility, and in secondarily brachypterous or completely wingless insects. Intraspecific phoresy also occurs. Generally, immature stages resistant to environmental assaults, such as dauers in nematodes, triungulins in beetles, or deutonymphs in mites, undertake phoresy. A size differential between rider and rider enables several conspecifics to board the same vehicle, likely ensuring mating opportunities at the destination. Riders may have special attachment devices or adhesive secretions to ensure safety during travel. Life cycles of riders and vehicles are often synchronized, and when phoresy is mutualistic, vehicles may also employ chemical tactics to achieve this synchrony. Chemical cues help to identify the appropriate vehicle, for disembarkation, or to lure the vehicle towards riders. Most riders prefer female vehicles, possibly to ensure access to rich nesting sites. Density-dependent selection may operate to limit the number of riders on a vehicle and phoresy may also facilitate sexual selection among riders. Whether vehicles can avoid phoresy is barely understood. This review attempts to place phoresy within a broad evolutionary context and points out the paucity of knowledge in certain research areas.