Miracle-dz/UniFAR-FTUs huggingface dataset:
Gene Expression of the NO 3 (cid:1) Transporter NRT1.1 and the Nitrate Reductase NIA1 Is Repressed in Arabidopsis Roots by NO 2 (cid:1) , the Product of NO 3 (cid:1) Reduction

NRT1 . 1 and NIA1 genes, which encode a nitrate (NO 3 (cid:1) ) transporter and the minor isoform of NO 3 (cid:1) reductase (NR), respectively, are overexpressed in roots of NR-deficient mutants of Arabidopsis grown on nutrient solution containing NO 3 (cid:1) and reduced N. The overexpression is found only in mutants with reduced NIA2 activity, and disruption of the NIA1 gene alone has no effect on NRT1 . 1 expression. Because the up-regulation of NRT1 . 1 and NIA1 is observed in N-sufficient NR mutant plants, it cannot be related to a release of the general feedback repression exerted by the N status of the plant. Our data do not support the hypothesis of overinduction of these genes by an increased concentration of NO 3 (cid:1) in tissues. Furthermore, although a control by external pH might contribute to the regulation of NRT1.1 , changes in external pH due to lack of NR activity cannot alone explain the up-regulation of both genes. The stimulation of NRT1 . 1 and NIA1 in NR mutants in these conditions suggests that NR activity is able to repress directly the expression of both genes independently of the availability of reduced N metabolites in wild-type plants. Accordingly, nitrite (NO 2 (cid:1) ) strongly represses NRT1 . 1 and NIA1 transcript accumulation in the roots. This effect is rapid, specific, and reversible. Furthermore, transport studies on plants exposed to NO 2 (cid:1) show that down-regulation of the NRT1 . 1 gene is associated with a decrease in NO 3 (cid:1) influx. These results indicate that feedback regulation of genes of NO 3 (cid:1) assimilation relies not only on the repression exerted by reduced N metabolites, such as NH 4 (cid:2) or amino acids, but may also involve the action of NO 2 (cid:1) as a regulatory signal.
A Secure Multi-Variate Routing Framework for Wireless Sensor Network

: Wireless sensor structures (WSNs) are more and more body deployed in freedom-critical applications. Because of their instinctive resource-constrained characteristics, they are ready to different insurance hurts, and an enraged hole hurt is a type of besiege that badly affects data assortment. To achieve that challenge, a keen uncovers ion-based care and protection routing proposal picked Active Trust is planned for WSNs. The most essential vicissitude of Active Trust is full avoids spotted holes over the enthusiastic production of offinding transmits to hurriedly disclose and procure nodal protection and thus progress the data line confidence. More essentially, the period and transport of finding lines require in the Active Trust scenario, whatever can amply use the potential in non-hotspots to start as many uncover ion lines as desired to produce the desired insurance and strength adaptability. Both sweeping imaginative search and developmental results imply that the show of the Active Trust blueprint is correct than that of preceding studies. Active Trust can kind of boost the data road prosperity feasibility and ingenuity in contrast to hostile hole besieges and can correct chain lifetime.
Mechanisms of harmol sulfate biliary excretion in mice and rats

Previous experiments demonstrated that the biliary excretion of harmol sulfate (HS) was mediated by Bcrp, and not by Mrp2 or P-glycoprotein in mice. However, recent reports suggested that species differences in hepatic canalicular transport mechanisms for a given substrate exist between mice and rats. In the present study, biliary excretion of HS was examined in perfused livers from mice and rats in the absence or presence of the P-glycoprotein and Bcrp inhibitor, GF120918. As expected, in mouse liver perfusions the biliary excretion of HS was decreased ~3.5-fold by GF120918, consistent with previous reports of Bcrp-mediated HS biliary excretion. However, despite sufficient hepatic unbound concentrations of GF120918 to achieve extensive inhibition of Bcrp, the biliary excretion of HS was not decreased significantly in rats (50 ± 12 vs. 41 ± 6 %). In summary, biliary excretion of HS was mediated by a GF120918-sensitive mechanism in mice, previously elucidated as Bcrp. In contrast the pathway responsible for HS biliary excretion in rats was not impaired by GF120918. Thus, transport mechanism(s) responsible for harmol sulfate biliary excretion appear to differ between mice and rats. 0% B, 4.1–6.0 min linear gradient to 0% B, 3.1–4 min hold at 0% B; flow rate = 0.65 mL/min; 1–5 min directed to mass spectrometer) and were detected in positive ion mode using multiple reaction monitoring: harmol: 199 → 131 m/z, HS: 279 → 199 m/z, cimetidine: 253 → 117 m/z. Analytes in mouse samples were eluted from an Aquasil C18 column (2.1 × 50 mm, d p = 5 µm, Thermo Electron Corporation, Waltham, MA) using a mobile phase gradient (A: 0.05% formic acid, B: 0.05% formic acid in methanol; 0–0.75 min hold at 0% B, 0.75–2 min linear gradient to 70% B, 2–3.5 min hold at 70% B, 3.5–3.6 min linear gradient to 0% B, 3.6–4 min hold at 0% B; flow rate = 0.75 mL/min; 0.8–4 min directed to mass spectrometer) and were detected in positive ion mode: harmol: 199 → 131 m/z, cimetidine: 253 → 117 m/z, or negative ion mode: HS: 277 → 197 m/z, cimetidine: 251 → 157 m/z.
Human-carnivore conflict over livestock: the African wild dog in central Botswana

Large carnivore populations have declined worldwide in the last century (Ginsberg and Macdonald 1990, Nowell and Jackson 1996), primarily as a result of conflict with humans (Gittleman et al. 2001). Carnivores are implicated in a wide range of conflict types including human predation (Kruuk 2002), spread of disease (Guan et al. 2003), and competition for prey species with humans (Ginsberg 2001). Prey competition can be especially acute and emotive in the context of carnivores preying on farmed ungulates (Fritts et al. 2003). Depredation conflict has been shown to cause locally intense economic losses (Kruuk 2002), to prompt retaliatory killing directed at culpable carnivores (Ogada et al. 2003) as well as innocent ones (Sacks et al. 1999), and to exacerbate decline and inhibit recovery for several carnivore species (e.g., snow leopards: Mishra 1997, wolves: Mech and Boitani 2003). The consequences are dire: two species of predatory mammals involved in livestock depredation conflict, the Tasmanian wolf and the Falkland Island fox, have already gone extinct in the last two centuries (Woodroffe et al. in prep). To avoid further extinctions, conservation biologists must work toward a better understanding of how carnivores can coexist with people. Population recovery, recolonization, or reintroduction schemes will not succeed unless the original cause of population decline has been eliminated or reduced (Reading and Clark 1996). For many large carnivore species, then, continued existence relies on mitigating livestock depredation. In this context, African wild dogs have been the focus of intensive conservation concern due a severe reduction in range, successive extinctions even in protected areas, and the endangered status of the remaining 3,000-5,000 individuals (Fanshawe et al. 1991, Woodroffe et al. 1997). Wild dogs have also been reported to prey on livestock wherever researchers have looked in or near human communities (Kenya: Woodroffe 2003; Namibia: Robin Lines, pers. comm.; South Africa: Lindsey 2003; Zimbabwe: Rasmussen 1999) and lethal control is a major factor contributing to the species’ current population collapse (Woodroffe et al. 1997). In this paper, I review the natural history and current decline of wild dogs, discuss depredation behavior and strategies used to mitigate human-carnivore conflict, and finally, propose future directions and questions for my dissertation research.
Highly replicated evolution of parapatric ecotypes 1

Parallel evolution of ecotypes occurs when selection independently drives the evolution of 9 similar traits across similar environments. The multiple origins of ecotypes are often inferred 10 based on a phylogeny that clusters populations according to geographic location and not by 11 the environment they occupy. However, the use of phylogenies to infer parallel evolution in 12 closely related populations is problematic because gene flow and incomplete lineage sorting 13 can uncouple the genetic structure at neutral markers from the colonization history of 14 populations. Here, we demonstrate multiple origins within ecotypes of an Australian 15 wildflower, Senecio lautus . We observed strong genetic structure as well as phylogenetic 16 clustering by geography and show that this is unlikely due to gene flow between parapatric 17 ecotypes, which was surprisingly low. We further confirm this analytically by demonstrating 18 that phylogenetic distortion due to gene flow often requires higher levels of migration than 19 those observed in S. lautus . Our results imply that selection can repeatedly create similar 20 phenotypes despite the perceived homogenizing effects of gene flow.
Design of Coplanar Waveguide Antenna for LTE Application

In this paper, a circular patch antenna with Coplanar Waveguide (CPW) feed for LTE application is proposed. The advanced antenna displays a decent impedance matching inside the LTE Bands 2600 MHz. The planar monopole radio wires with coplanar waveguide (CPW) nourishing component has considered here. Its points of interest over microstrip compose feed lines, low scattering, low radiation spillage, the capacity to successfully control the trademark impedance, and the simplicity of mix. The proposed antenna is compact in size and less cost to fabricate. The gain and efficiency of this antenna is good. The antenna designed by the software simulator high frequency structure simulator (HFSS).
Bortezomib-Based Antibody-Mediated Rejection Therapy and Simultaneous Conversion to Belatacept

ow naded rom http:urnals.lw w om /transtjournalby hD M fePH bH 4TIm qVAH xkFJpPk1L/H vM G w qM xG jw O deJPG +b4D lKuA44qu/vw zm c= on 070/2018 Downloadedfromhttp://journals.lww. com/transplantjournalbyBhDMf5ePHKbH4TTImqenVAHxkFJp/XpPk1L/H3vMGwqMxG9jwOd8eJPG+b4DlKuAX44qu/vwzmc=on07/30/2018 patients and the public are diverse and, not surprisingly, dependent on circumstances. Public and patient input into service design will help shape a service that reflects the attitudes of both donors and recipients but must be undertaken cautiously and, these results suggest, may not accord with the views of all stakeholders. Richard Parker Jonathan Catling James W. Ferguson James M. Neuberger 1 NIHR Centre for Liver Research and Biomedical Research Unit University of Birmingham Birmingham, UK 2 Liver Unit Queen Elizabeth Hospital University Hospitals Birmingham Birmingham, UK 3 School of Psychiatry University of Birmingham Birmingham, UK 4 NHS Blood and Transplant Bristol, UK
Prospect Theory for Online Financial Trading how this access benefits you. Your story matters

Prospect theory is widely viewed as the best available descriptive model of how people evaluate risk in experimental settings. According to prospect theory, people are typically risk-averse with respect to gains and risk-seeking with respect to losses, known as the ‘‘reflection effect’’. People are much more sensitive to losses than to gains of the same magnitude, a phenomenon called ‘‘loss aversion’’. Despite of the fact that prospect theory has been well developed in behavioral economics at the theoretical level, there exist very few large-scale empirical studies and most of the previous studies have been undertaken with micro-panel data. Here we analyze over 28.5 million trades made by 81.3 thousand traders of an online financial trading community over 28 months, aiming to explore the large-scale empirical aspect of prospect theory. By analyzing and comparing the behavior of winning and losing trades and traders, we find clear evidence of the reflection effect and the loss aversion phenomenon, which are essential in prospect theory. This work hence demonstrates an unprecedented large-scale empirical evidence of prospect theory, which has immediate implication in financial trading, e.g., developing new trading strategies by minimizing the impact of the reflection effect and the loss aversion phenomenon. Moreover, we introduce three novel behavioral metrics to differentiate winning and losing traders based on their historical trading behavior. This offers us potential opportunities to augment online social trading where traders are allowed to watch and follow the trading activities of others, by predicting potential winners based on their historical trading behavior.
Global SH-wave propagation using a parallel axi-symmetric finite-difference scheme

SUMMARY We extended a high-order finite-difference scheme for the elastic SH wave equation in axi-symmetric media for use on parallel computers with distributed memory architecture. Moreover we derive an analytical description of the implemented ring source and compare it quantitatively with a double couple source. The restriction to axi-symmetry and the use of high performance computers and PC networks allows computation of synthetic seismograms at dominant periods down to 2.5 seconds for global mantle models. We give a description of our algorithm (SHaxi) and its verification against an analytical solution. As an application, we compute synthetic seismograms for global mantle models with additional stochastic perturbations applied to the background S-wave velocity model. We investigate the influence of the perturbations on the SH wave field for a suite of models with varying perturbation amplitudes, correlation length scales, and spectral characteristics. The inclusion of stochastic perturbations in the models broadens the pulse width of teleseismic body wave arrivals and delays their peak arrival times. Coda wave energy is also generated which is observed as additional energy after prominent body wave arrivals. The SHaxi method has proven to be a valuable method for
Appendix A – Elaboration of the main text

Literature searches were performed in PubMed using Medical Subject Headings (MESH) terms and keywords “(? sequenc* OR metagenom* OR Illumina OR RNA-seq OR RNASeq OR (Roche 454) OR (Ion torrent) OR (Proton / PGM) OR MiSeq OR HiSeq OR NextSeq OR MinION OR Nanopore OR PacBio) AND (infectio* OR microorganism OR microorganisms OR pathogen OR pathogens OR bacteria* OR virus OR viral OR fungus OR fungi OR parasite OR parasites OR parasitic)”, searching references of articles, and supplemented by expert opinion from within the group. Articles were limited to those in English language published between January 2000 and June 2019.
An Elaborative Study on Routing Protocols in Wireless Sensor Networks: A Survey

________________________________________________ Abstract — Wireless Sensor Networks have originated vast significance after the expansion of wireless technology. A Wireless Sensor Network is an amalgamation of enormous amount of sensing devices termed sensor nodes. In Wireless Sensor Networks (WSNs) due to the constraints the nodes, power and energy effectiveness is an essential point which should be well-thought-out at the instance of scheming of protocols. Wireless Sensor Networks in recent times move toward into distinction for the reason that they hold the impending to transform segment of our cost-cutting work out and existence with its broad applications. Several applications comprise like landslide detection, glacial monitoring, wildlife tracking, health care, military applications, environmental monitoring and a huge quantity of applications to robotics, internet of things etc. The articulation of information is based on the Routing Protocols which chooses the optimum route involving any number of nodes. Various types of Routing Protocols are useful to specific network surroundings. Routing Protocols for Wireless Sensor Networks are responsible for retaining the routes in the network and guarantee dependable multi-hop transmission beneath these situations. The paper reviews the WSNs Architecture and Design as well as Routing Protocols Taxonomy, Prime Routing Protocols and its further Research Areas in association with Wireless Sensor Networks.
Distribution of human-specific Bacteroidales and fecal indicators in an 1 urban watershed impacted by sewage pollution using RNA and DNA 2 based quantitative PCR assays

The identification of fecal pollution sources is commonly carried out using DNA-based methods. 20 However, there is evidence that DNA can be associated with dead cells or present as “naked DNA” in the environment. Furthermore, it has been shown that rRNA-targeted RT-qPCR assays 22 can be more sensitive than rDNA-based qPCR assays since metabolically active cells usually 23 contain higher numbers of ribosomes than quiescent cells. To this end, we compared the 24 detection frequency of host specific markers and fecal bacteria using RNA-based RT-qPCR and 25 DNA-based qPCR methods for water samples collected in sites impacted by combined sewer 26 overflows. As a group, fecal bacteria were more frequently detected in most sites using RNA- 27 based methods. Specifically, 8%, 87%, and 85% of the samples positive for general enterococci, 28 Enterococcus faecalis , and E. faecium markers respectively, were detected using RT-qPCR, but 29 not with the qPCR assay counterpart. On average, two human-specific Bacteroidales markers 30 were not detected when using DNA in 12% of the samples while they were positive for all 31 samples when using RNA (cDNA) as the template. Moreover, signal intensity was up to three 32 orders of magnitude higher in RT-qPCR assays than in qPCR assays. The human-specific 33 Bacteroidales markers exhibited moderate correlation with conventional fecal indicators using 34 RT-qPCR results, suggesting the persistence of non-human sources of fecal pollution or the 35 presence of false positive signals. In general, the results from this study suggest that RNA-based 36 assays can increase the detection sensitivity of fecal bacteria in urban watersheds impacted with 37 human fecal sources. 38
Class Progression Phase Sequence Grouping with Cooperative Transformation Centered Ensembles

— In recent times, dualistic notions have been discovered that lead to more precise procedures for Phase - Sequence Grouping (PSG). Initially, it remained exposed that the artless method to increase progress on PSG complications is to renovate into an alternate information space wherever biased features are certainly noticed. Succeeding proof of an individual information depiction, enriched correctness that can be attained over artless cooperative patterns. These dual ideologies are associated to assess the premise that bring into existence a cooperative groups of classifiers on dissimilar information renovations to progress the correctness of PSG through Class Progression Phase Sequence Grouping (CPPSG). For the phase area, a set of flexible remoteness trials are used. The artless cooperative pattern is demonstrated by comprising all classifiers in single cooperative pattern is meaningfully more precise than any of its mechanisms and to some extent supplementary methods available in earlier Time-series Classifier procedures.
Optimal 1,5-anhydroglucitol cut-off points for diagnosing diabetes based on prevalence of retinopathy in Chinese population

Cheng CHEN Southeast University Zhongda Hospital Shanhu QIU Southeast University Zhongda Hospital Ziwei DU Southeast University Zhongda Hospital Haijian GUO Jiangsu Provincial Center for Disease Control and Prevention Bei WANG Southeast University Zilin SUN Southeast University Zhongda Hospital Yao Wang (  wang_yao100@163.com ) Southeast University Zhongda Hospital https://orcid.org/0000-0001-5433-7360
Development and external validation of a diagnostic model for in-hospital bleeding in patients with acute ST elevation myocardial infarction

Background: Bleeding complications in patients with acute ST segment elevation myocardial infarction (STEMI) are associated with an increased risk of subsequent adverse consequences. We want to develop and externally validate a diagnostic model of in-hospital bleeding in the population of unselected real-world patients with acute STEMI. Methods: Design: Multivariable logistic regression of a cohort for hospitalized patients with acute STEMI . Setting: Emergency department ward of a university hospital. Participants: Diagnostic model development: Totally 4262 hospitalized patients with acute STEMI from January 2002 to December 2013 in Beijing Anzhen Hospital, Capital Medical University. External validation: Totally 6015 hospitalized patients with acute STEMI from January 2014 to August 2019 in Beijing Anzhen Hospital, Capital Medical University. Outcomes: All-cause in-hospital bleeding not related to coronary artery bypass graft surgery or catheterization. Results: In-hospital bleeding occurred in 2.6% of patients in the development data set and 1.9% （ ） of patients in the validation data set. The strongest predictors of in-hospital bleeding were advanced age and high Killip classification. We developed a diagnostic model of in-hospital bleeding. The area under the receiver operating characteristic curve (AUC) was We constructed a nomograms using the development database based on age , and Killip classification. The AUC was 0.7234±0.0252, 95% CI= 0.67392 ~ 0.77289 in the validation data set . Discrimination, calibration, and decision curve analysis were satisfactory. Conclusions: We developed and externally validated a moderate diagnostic model of in-hospital bleeding in patients with acute STEMI . We this study
An Analysis Framework for Media Multitasking Performance Degradation

Because of increasing the opportunities of media multtasking, growing worries rises in introducing new information devices such as smart phone and pad type computers to youths and children’s learning and developemnt, and some reseachers reported the diffiecncies of media multitasking withought research framework of analysis the performance degradation. In this paper, we apply the cognitive load theory and show if users have more motivation to specific task under media multitasking emvironments, their performance are not significantly affected.
Effect of preparation conditions reaction temperature on the morphology of nanosized HAp

We reported on the synthesis of nanosized hydroxyapatite particles by wet chemical precipitation method and the consolidation of the nanoparticles by spark plasma sintering. We studied the effect of the synthesis temperature on the particle size and phase composition of the obtained HAp. During synthesis beyond HAp, another phase supposedly nonstoichiometric HAp was also formed as a by-product that can be de-tected by thermal analysis combined with XRD. Its amount was gradually decreased with increasing synthesis temperature and practically disappeared at 80 °C. Using this nanopowder for sintering the spark plasma sintered ceramics retained its nanostructure comprising only HAp phase in contrast to the powders synthesized at lower temperature when transformed products of the nonstoichiometric HAp could also be detect-ed.
Inﬂuence of Various Kinds of Capital at the Economic Efﬁciency of Enterprises in Russia

The article investigates the relation of human and physical capital. Past surveys have yielded interrelation between the using of these parameters on the enterprises of Russia. Revealed the presence of a linear relationship between the calculated parameters, and the data, were deﬁned from the experts. Obtained justiﬁcation of provisions that material factors in Russia means much more than intangible.