Miracle-dz/UniFAR-FTUs huggingface dataset:
Empirical Comparison of Neural Network and Auto-Regressive Models in Short-Term Load Forecasting

Artificial Intelligence (AI) has been widely used in Short-Term Load Forecasting (STLF) in the last 20 years and it has partly displaced older time-series and statistical methods to a second row. However, the STLF problem is very particular and specific to each case and, while there are many papers about AI applications, there is little research determining which features of an STLF system is better suited for a specific data set. In many occasions both classical and modern methods coexist, providing combined forecasts that outperform the individual ones. This paper presents a thorough empirical comparison between Neural Networks (NN) and Autoregressive (AR) models as forecasting engines. The objective of this paper is to determine the circumstances under which each model shows a better performance. It analyzes one of the models currently in use at the National Transport System Operator in Spain, Red Eléctrica de España (REE), which combines both techniques. The parameters that are tested are the availability of historical data, the treatment of exogenous variables, the training frequency and the configuration of the model. The performance of each model is measured as RMSE over a one-year period and analyzed under several factors like special days or extreme temperatures. The AR model has 0.13% lower error than the NN under ideal conditions. However, the NN model performs more accurately under certain stress situations.
Properties of Fiber-Reinforced One-Part Geopolymers: A Review

Geopolymers have the advantages of low carbon, being environmentally friendly and low price, which matches the development direction of building materials. Common geopolymer materials are also known as two-part geopolymers (TPGs). TPGs are usually prepared from two main substances, which are formed by polymerization of a silicoaluminate precursor and an alkaline activator solution. The TPG has many limitations in engineering application because of its preparation on the construction site, and the use of solid alkaline activator in one-part geopolymers (OPGs) overcomes this shortcoming. However, the brittleness of OPGs such as ceramics also hinders its popularization and application. The properties of the new OPG can be improved effectively by toughening and strengthening it with fibers. This review discusses the current studies of fiber-reinforced one-part geopolymers (FOPGs) in terms of raw precursors, activators, fibers, physical properties and curing mechanisms. In this paper, the effects of the commonly used reinforcement fibers, including polyvinyl alcohol (PVA) fiber, polypropylene (PP) fiber, polyethylene (PE) fiber, basalt fiber and other composite fibers, on the fresh-mixing properties and mechanical properties of the OPGs are summarized. The performance and toughening mechanism of FOPGs are summarized, and the workability, macroscopic mechanical properties and durability of FOPGs are investigated. Finally, the development and engineering application prospect of FOPGs are prospected.
Distribución natural de Taxodium huegelii C. Lawson en el estado de Hidalgo

Taxodium huegelii (sinónimo: Taxodium mucronatum) es un árbol que habita en bosques de galería; sus nombres comunes son ahuehuete, árbol de Tule, ciprés de Montezuma o sabino. El objetivo de esta investigación fue generar mapas de distribución actual y potencial para la especie en el estado de Hidalgo. Para elaborarlos se emplearon 56 registros, obtenidos de colectas en campo y una búsqueda en bases de datos. Los registros se analizaron previamente para evitar errores de procedencia y datos repetidos. El mapa de distribución documentada se generó con ArcGIS® versión 10.3 y el mapa de distribución potencial mediante Maxent versión 3.4. 1. Las provincias biogeográficas Altiplano Sur (Zacatecano-Potosino), Sierra Madre Oriental y el Golfo de México fueron las únicas que tuvieron registros de presencia, los cuales se localizaron en 23 de los 84 municipios de Hidalgo; sin embargo, de acuerdo con los resultados, existe 46 % de idoneidad para que la especie se distribuya en 63 municipios del estado. El modelo de distribución potencial es satisfactorio, ya que tiene una predicción de 92 %. La distribución de T. huegelii se favorece en zonas donde la temperatura mínima del mes más frío no es menor a 3 °C, y en lugares con un intervalo de precipitación de 100 a 500 mm. Los mapas de distribución real y potencial generados constituyen la base para futuras investigaciones sobre este taxon emblemático de México.
A Symmetrical Double Step-Down Converter With Extended Voltage Conversion Ratio

The Hybrid DC-DC converter, especially with multiple inductors targeting high current delivery, has the advantages of high efficiency and power density with a large voltage conversion ratio (VCR), due to the combination of the benefits of both switched-capacitor-based and inductor-based buck converters. However, a higher number of inductors means that the energizing time for each inductor has more limitations, resulting in a relatively narrower VCR range. To reduce the conduction loss and extend the voltage conversion ratio scope, this paper presents a symmetrical double step-down (SDSD) converter with a VCR range up to 1/3, regulating an output voltage interval of 0.5 V-0.8 V from a 2.7 V-4.2 V Lithium-ion battery. This converter, implemented in 65 nm CMOS, occupies a core active area of 1.53 mm2. This work obtains 86.5% peak efficiency and 326 mA/mm2 maximum current density, with an effective switching frequency of 3 MHz.
The Use of Distance Fences In Reducing Dental Pain in The Community of the Bireuen District

Dental and oral health problems, especially dental cavities (caries), are still many complaints by both children and adults. Traditional medicine is still developing in the community by utilizing herbal plants. One of the plants that are widely used to reduce tooth pain is jatropha gum. Jatropha gum is still believed to reduce pain in teeth. This study aimed to determine the relationship between the use of jatropha sap in reducing tooth pain in the community in Cot Gapu Village, Juang City District, Bireuen Regency. This research is analytic with the cross-sectional approach. The population in this study were all people in Cot Gapu Village, Kota Juang District, Bireuen Regency, who suffered from toothache, totaling 82 people with a sample of 46 people. The Random Sampling technique did sampling. The study's results found a relationship between the use of Jatropha gum in reducing tooth pain in the community. Jatropha gum is used to cure dental caries by dripping one or two drops of sap into the tooth cavity. Jatropha sap contains flavonoids that can function as antifungal, antiseptic, and anti-inflammatory, also contains saponins that can stimulate collagen growth in the healing process and also have the effect of relieving pain and stimulating the formation of new cells.
Genome Assembly and Genetic Traits of the Pleuromutilin-Producer Clitopilus passeckerianus DSM1602

The gilled mushroom Clitopilus passeckerianus (Entolomataceae, Agaricales, Basidiomycota) is well known to produce the terpenoid pleuromutilin, which is the biotechnological basis for medically important antibiotics such as lefamulin and retapamulin. Their unique mode of action and good tolerance entails an increasing demand of pleuromutilin-derived antibiotics in veterinary and human health care. Surprisingly, despite their pharmaceutical importance, no genome sequence is available of any pleuromutilin-producing fungus. Here, we present the high-quality draft genome sequence of the pleuromutilin-producer C. passeckerianus DSM1602 including functional genome annotation. More precisely, we employed a hybrid assembly strategy combining Illumina sequencing and Nanopore sequencing to assemble the mitochondrial genome as well as the nuclear genome. In accordance with the dikaryotic state of the fungus, the nuclear genome has a diploid character. Interestingly, the mitochondrial genome appears duplicated. Bioinformatic analysis revealed a versatile secondary metabolism with an emphasis on terpenoid biosynthetic enzymes in C. passeckerianus and also in related strains. Two alleles of biosynthetic gene clusters for pleuromutilin were found in the genome of C. passeckerianus. The pleuromutilin genes were reassembled with yeast-specific elements for heterologous expression in Saccharomyces cerevisiae. Our work lays the foundation for metabolic strain engineering towards higher yields of the valuable compound pleuromutilin.
Evaluation of efficacy and tolerability of hepameg (probiotics + eicosapentaenoic acid + docosahexaenoic acid + vitamin E) in the management of non-alcoholic fatty liver disease

Background: Non-Alcoholic Fatty Liver Disease (NAFLD) has currently emerged as common liver disorder compared to alcoholic liver disease. Available treatments are associated with certain side-effects. Recently a relation between gut and liver, i.e. gut-liver axis has been studied extensively. Modulation of gut may provide a natural mechanism to improve NAFLD associated complications. Aim: To evaluate the efficacy and tolerability of Hepameg. Patients were given 1 gram Hepameg sachet containing probiotics, omega-3-fatty acids and vitamin E twice a day for 12 weeks. Methods: An open-label, non-comparative post marketing study was conducted in 20 subjects with NAFLD. Physical and biochemical investigations were performed and inflammatory markers were assessed at baseline and after 12 weeks. Primary outcomes were change in scores for Fibrosis-4 (FIB-4) and AST to Platelet Ratio Index (APRI) at baseline and week 12. Secondary outcomes were global assessment of efficacy by physician and patients on a pre-defined 0 to 4 score scale. Results: After 12 weeks of Hepameg therapy, all patients reported significant improvement in FIB-4 and APRI scores. On the predefined scale of global assessment, physicians and patients reported excellent efficacy and tolerability rating for Hepameg. Conclusion: The results of the study showed that Hepameg is clinically effective and safe in the management of NAFLD. Keywords: non-alcoholic fatty liver disease; probiotics; omega-3-fatty acids; vitamin E.
Importance of Public Transport Networks for Reconciling the Spatial Distribution of Dengue and the Association of Socio-Economic Factors with Dengue Risk in Bangkok, Thailand

Dengue is the most widespread mosquito-borne viral disease of man and spreading at an alarming rate. Socio-economic inequality has long been thought to contribute to providing an environment for viral propagation. However, identifying socio-economic (SE) risk factors is confounded by intra-urban daily human mobility, with virus being ferried across cities. This study aimed to identify SE variables associated with dengue at a subdistrict level in Bangkok, analyse how they explain observed dengue hotspots and assess the impact of mobility networks on such associations. Using meteorological, dengue case, national statistics, and transport databases from the Bangkok authorities, we applied statistical association and spatial analyses to identify SE variables associated with dengue and spatial hotspots and the extent to which incorporating transport data impacts the observed associations. We identified three SE risk factors at the subdistrict level: lack of education, % of houses being cement/brick, and number of houses as being associated with increased risk of dengue. Spatial hotspots of dengue were found to occur consistently in the centre of the city, but which did not entirely have the socio-economic risk factor characteristics. Incorporation of the intra-urban transport network, however, much improved the overall statistical association of the socio-economic variables with dengue incidence and reconciled the incongruous difference between the spatial hotspots and the SE risk factors. Our study suggests that incorporating transport networks enables a more real-world analysis within urban areas and should enable improvements in the identification of risk factors.
The greening reaction of skipjack tuna (Katsuwonus pelamis) metmyoglobin promoted by free cysteine during thermal treatment

Background Tuna muscle greening is a problem that occurs after heating. A hypothesis has been postulated to address this problem, involving a conserved Cys residue at position 10 (Cys-10) present on tuna myoglobin (Mb) that is exposed during the thermic treatment, forming a disulfide bond with free cysteine (Cys) in the presence of trimethylamine oxide (TMAO), resulting in the greening of the tuna Mb. Methods We present a study using skipjack tuna (Katsuwonus pelamis) metmyoglobin (MbFe(III)-H2O) where the effect of free Cys (1–6 mM), TMAO (1.33 mM), and catalase on the greening reaction (GR) was monitored by UV-vis spectrometry during thermal treatment at 60 °C for 30 min. Moreover, the participation of Cys-10 on the GR was evaluated after its blocking with N-ethymaleimide. Results The GR occurred in tuna MbFe(III)-H2O after heat treatment with free Cys, forming sulfmyoglobin (MbFe(II)-S) as the responsible pigment for the tuna greening. However, the rate constants of MbFe(II)-S production depended on Cys concentration (up to 4 mM) and occurred regardless of the TMAO presence. We postulate that two consecutive reactions involve an intermediate ferrylmyoglobin (promoted by H2O2) species with a subsequent MbFe(II)-S formation since the presence of catalase fosters the reduction of the rate reaction. Moreover, GR occurred even with blocked Cys-10 residues in tuna Mb and horse Mb (without Cys in its sequence). Discussion We found that GR is not exclusive to tuna Mb´s, and it can be promoted in other muscle systems. Moreover, Cys and thermal treatment are indispensable for promoting this pigmentation anomaly.
Visual Memory Neural Network for Artistic Graphic Design

Artistic graphic design is the aesthetic result of the designer’s fusion of various elements, with a high degree of independence. Considering the lack of significant visual design scope and aesthetic indicators of graphic design, our research aims to build an upgraded network model that can categorize different types of artistic graphics with labels and realize the free combination of graphic solutions. We realize the scheme reorganization of artistic graphic design from the perspective of computer vision and propose the artistic graphic design method based on memory neural network. We built a computer vision environment and reconstructed the computer vision network to set up an independent deep camera vision range calculation law. Considering the artistic graphic region segmentation problem, we propose the self-attentive mechanism, which can quantitatively segment different artistic graphic regions according to temporal features, before arranging them in a sequence to obtain the graphic region feature vector. We also add the LSTM structure based on the attention mechanism to match with the self-attention features of the graphical region segmentation module and pass the matched attention feature vector to the LSTM network to extract the labeled text feature information of the graphs. To test the effectiveness of our method, we build a database of artistic graphics and set up an adaptive training process. We also compared deep learning methods of the same type, and the experimental results proved that our method outperformed other deep methods in artistic graphic design by keeping the scheme reorganization accuracy and quantitative evaluation of artistic models above 90%.
Decarbonizing the downturn: Addressing climate change in an age of stagnation

Meeting the Paris climate goals requires the global economy’s urgent decarbonization. States and intergovernmental bodies insist that this should be pursued via a tremendous spike in private investment in renewable power – encouraged and coordinated by states. However, this renewable investment boom will have to swim against the current of the stagnation of the world economy since the 1970s, characterized by weak rates of investment and growth. Undertaking decarbonization in this context presents unique political economy dilemmas. Firstly, although slow growth helps to reduce carbon emissions by lowering energy use, it simultaneously impedes energy efficiency gains. Secondly, the stagnant state of global industry militates against its adoption of expensive decarbonized industrial processes. Thirdly, while most renewable power sources have failed to attract sufficient investment, those that have expanded rapidly – particularly solar photovoltaic – have tended to exhaust their growth potential due to falling prices and profitability. Finally, economic stagnation has destabilized political institutions, exerting pressures on governments to stimulate growth regardless of the environmental implications. States must navigate these intractable dilemmas as they strategize to decarbonize the downturn.
A Disintegrin and Metalloprotease 10 Expressions Modulate Potential Metastatic and Thrombus Formation in Pancreatic Carcinoma

Background: Clinical investigations repurposing a disintegrin and metalloproteases 10 (ADAM10) as metastatic and thrombus marker have achieved encouraging results, but the mechanism behind this association remains unclear. Methods: This study was carried out in NingXia and Wuhan, China from 2017 to 2021. The effects of ADAM10 expression on the metastatic and thrombus-associated genes: tissue factor (TF), P-selectin glycoprotein ligand-1 (PSGL-1), cathepsin G (CTSG) and mucin 1 (MUC1) were examined by immunofluorescence, qRTPCR and Western blotting analysis. Metastatic and thrombotic behaviors were evaluated using NODSCID mouse model. Results: The ADAM10 expression controlled the migration and invasion of pancreatic carcinoma cell-1(PANC-1), and significantly regulated the metastatic and thrombus-associated genes (P<0.05). ADAM10 and MUC1 were regulated and aberrantly expressed by a dependent mechanism. Moreover, ADAM10 expression induced the progression of adenocarcinoma cells and thrombus formation in vivo. Conclusion: Regulation of ADAM10 expression in cancer cells might effectively pave the way for a more potent anti-metastatic and anti-thrombotic approach and could regulate the invasion and migration of cancer cells.
GeV Electron Acceleration by Trapezoidal Laser Pulse Envelope Under Combined Effect of Frequency Chirp and Axial Magnetic Field in Vacuum

In the present article, we have investigated efficient electron acceleration by employing trapezoidal laser pulse envelope under the combined effect of linear chirp and external axial magnetic field in vacuum. In this envelope, the electric signal linearly rises to a certain level, stay there, and then falls back to its initial level. So, there will be an opportunity to increase the interaction time between laser pulse and electron for efficient energy transfer, which has been reflected in this study. A few megaelectronvolt electrons have been injected axially to the front of a trapezoidal short laser pulse. In all calculations, the front end of each laser pulse captures electron at <inline-formula> <tex-math notation="LaTeX">$t= 0$ </tex-math></inline-formula>. The dynamics arise from analytical and numerical solutions of Newton–Lorentz force equations of motion. Electron energy gain has been calculated for initial laser phase varying from 0 to <inline-formula> <tex-math notation="LaTeX">$2\pi $ </tex-math></inline-formula>. For the optimum set of laser parameters, we have observed electro’s energy gain of the order of GeV.
Radioimmunotherapy in HPV-Associated Head and Neck Squamous Cell Carcinoma

HPV-associated head and neck squamous cell carcinoma (HNSCC) is a cancer entity with unique biological and clinical characteristics that requires more personalized treatment strategies. As the backbone of conventional therapeutics, radiation is now harnessed to synergize with immunotherapy in multiple malignancies. Accumulating preclinical and clinical data have suggested the potential of radioimmunotherapy in eliciting local and systemic anti-tumor response via direct killing of tumor cells and immunogenic cell death. However, this effect remains uncertain in HPV-associated HNSCC. Owing to its intrinsic radiosensitivity and distinct tumor microenvironment, HPV-associated HNSCC may represent a good candidate for radioimmunotherapy. In this review, we provide a detailed illustration of the biology, the genomic features, and immune landscapes of HPV-associated HNSCC that support the synergism between radiation and immune agents. The interaction between radiotherapy and immunotherapy is described. We also highlight the present evidence as well as ongoing trials using different combination strategies in the recurrent/metastatic or definitive settings. In addition, we have summarized the challenges and outlook for future trial design, with special emphasis on radiotherapy optimization and novel therapeutic options to incorporate.
Effect of Physical and Enzymatic Modifications on Composition, Properties and In Vitro Starch Digestibility of Sacred Lotus (Nelumbo nucifera) Seed Flour

In this study, native lotus seed flour (N-LSF) was modified by different methods, namely, partial gelatinization (PG), heat–moisture treatment (HMT), or pullulanase treatment (EP). Their composition, functional properties, starch composition, and estimated glycemic index (eGI) were compared. PG contained similar protein, soluble dietary fiber, and insoluble dietary fiber contents to N-LSF, while those of HMT and EP differed from their native form. PG increased rapid digestible starch (RDS) but decreased resistant starch (RS); while HMT and EP increased amylose and RS contents to 34.57–39.23% and 86.99–92.52% total starch, respectively. Such differences led to the different pasting properties of the modified flours rather than PG, which was comparable to the native flour. HMT had limited pasting properties, while EP gave the highest viscosities upon pasting. The eGI of all samples could be classified as low (<50), except that of PG, which was in the medium range (60). It was plausible that lotus seed flour modified either with HMT or EP could be used as carbohydrate source for diabetes patients or health-conscious people.
Nandrolone Decanoate and Swimming Affects Cardiodynamic and Morphometric Parameters in the Isolated Rat Heart

(1) Background: The aim of this study was to show the effects of swimming and nandrolone administration on cardiodynamic and morphometric parameters of the isolated rat heart. (2) The study included 72 Wistar rats, divided into three groups, scheduled to be sacrificed after the second, third, and fourth week. Each group was divided into four subgroups: control (T-N-), nandrolone (T-N+), swimming training (T+N-), and swimming training plus nandrolone (T+N+) group. The rats from T+N- and T+N+ swam 1 h/day, 5 days/week while ones from T-N+ and T+N+ received weekly nandrolone decanoate (20 mg/kg). The isolated hearts were perfused according to the Langendorff technique and measured parameters: dp/dt max/min, SLVP, DLVP, heart rate, and coronary flow. Hearts were fixed and stained with H/E and Masson trichrome dyes. (3) dp/dt max and dp/dt min were increased in the T-N+ group at higher perfusion pressure compared to the T-N- group. SLVP and DLVP were increased in all groups after the 4th week. Collagen content was increased in T-N+ by 403% and in T+N+ by 357% groups, while it was decreased in T+N- compared to the control after 4th week. (4) Conclusions: Nandrolone alone or combined with swimming had a deleterious effect on myocardial function and perfusion.