Miracle-dz/UniFAR-FTUs huggingface dataset:
The Orion Molecular Cloud 2/3 and NGC 1977 Regions

The Orion Molecular Cloud 2/3 region (hereafter, OMC-2/3) and the reflection nebula NGC 1977 encompass a section of the Orion A molecular cloud undergoing vigorous star forming activity. One of the richest assemblages of protostars in the nearest 500 pc is seen in OMC-2/3, while NGC 1977 contains a cluster of over 100 young stars. In this review, we present a census of the protostars, pre-main sequence stars, and young brown dwarfs in these regions. These are identified through sub-millimeter surveys, far-red to near-infrared imaging and spectroscopy with ground-based telescopes, mid-infrared photometry from the Spitzer Space Telescope, and X-ray observations made with the Chandra X-ray Observatory. We present an overview of the distribution of molecular gas associated with these regions and the rich complex of shock heated nebulae created by the young stars interacting with the molecular gas. Finally, we discuss the relationship of OMC-2/3 and NGC 1977 to the neighboring Orion Nebula Cluster and the Orion OB1 association.
Radiation effects in light emitting diodes, laser diodes, photodiodes, and optocouplers

A variety of commercially available LEDs, LDs, PDs, and optocouplers from two German manufacturers were irradiated at a flash X-ray source, a /sup 60/Co gamma ray source, and a 14 MeV neutron generator. Light output and emission spectrum of the LEDs and LDs were measured before and after irradiation at the /sup 60/Co source. With the PDs we measured the dark current and the photo current before and after /sup 60/Co irradiation. Determination of the sensitivity against neutrons was made off-line. With PDs we measured the photo current induced by pulsed X-rays. The GaAs LED showed a maximum decrease of output power of 28 dB after a total gamma dose of 10/sup 6/ Gy and LDs a threshold current shift of 80% after neutron fluences of 4/spl middot/10/sup 14/ cm/sup -2/ (1 MeV). Irradiations of PDs and APDs with /sup 60/Co gammas up to a total dose of 10/sup 6/ Gy as well as irradiations with neutrons up to fluences of /spl lsim/4/spl middot/10/sup 14/ cm/sup -2/ (1 MeV) led to significant changes of the device parameters. The main effect was a strong increase of the dark current. The consequence was a reduction of the minimum detectable light power. Optocouplers are very sensitive to ionizing radiation. Gammas as well as neutrons led to a decrease of the CTR and a change of the bandwidth up to a complete failure (after neutron irradiation). <<ETX>>
Deviant language in the literary dialogue: An English–Romanian translational view

Abstract Drawing on the scholarly acknowledgement regarding the experimental nature of dialogue in Modern and Postmodern literature, this article attempts at investigating the translatability of dialogic utterances displaying deviant language. The relevance of the study is given by the structural differences between languages, which oftentimes triggers the impossibility of rendering the dialogic information relative to the literary characters’ identity in the target language. The examples are depicted from several fictional texts, where part of the characters’ identity is constructed by the peculiarities of their speech which deviates, in a range of manners, from standard English. Such deviant language indicates the characters’ idiolectal, sociolectal or dialectal identity, as well as the broader social context in which they act. The examination of deviant language leads to findings concerning its structural variety and its essential role in completing some literary characters’ identity and, implicitly, its importance in translation. Solutions are suggested to the interlingual transfer of formally untranslatable deviant language of a grammatical, phonological and lexical nature, taking also account of criteria pertaining to functional aspects. The conclusions discuss structural, phonological and lexical possibilities of the target language, the translator’s creative engagement in the translation of deviant identity-marking language and suggest further research opportunities.
Automatic coloring method of fine brushwork painting based on GAN

With the revival of traditional Chinese culture, a wave of fine brushwork painting as a popular element has been set off, but there are few studies on fine brushwork painting coloring. Based on Generative Adversarial Networks, this paper presents an automatic coloring method for fine brushwork painting. The generator uses U-NET network to solve the underlying information sharing problem. PatchGAN was used to ensure the performance of details. Smooth L1 loss is added to the loss function to make the generated image color transition smooth and more realistic. In order to solve the problem of single color drawing, color guidance information is added to the line drawing, so that it has the function of interactive color painting, and the specified color is realized in the line drawing. The experimental result shows that the automatic coloring method can quickly color line drawings, and the generated simulated fine brushwork paintings have distinct colors. The unique interaction mode improves the diversity of coloring effects.
Self-Reported Pain Tolerance and Opioid Pain Medication Use After Foot and Ankle Surgery

Background: Orthopaedic surgeons must consider their postoperative pain management strategies to minimize harm from prescription opioid use. Patients often reference their pain threshold to predict how they will tolerate surgical pain and the need for postoperative analgesia, but the direct relationship between these factors has not yet been studied. The purpose of this study was to determine the relationship between patients’ self-reported pain tolerance and prescription opioid usage after foot and ankle surgery. Methods: This is a retrospective follow-up of a prospective cohort study of adult patients who underwent outpatient foot and ankle surgeries. Patient and procedural demographics, opioid pills dispensed, and opioid pills consumed by the first postoperative visit were obtained. Patients were contacted at a mean of 13.1 ± 4.0 months postoperatively and asked to respond to the qualitative statement “Pain doesn’t bother me as much as it does most people. ” Patients were also asked their quantitative pain threshold (0-100), with 0 being “very pain intolerant” and 100 being a “very high pain tolerance,” as well other questions regarding past surgical and narcotic consumption history. Results: Of the 700 survey respondents, the average age was 50.9 years and 34.7% were male. Bivariate analysis determined that predictors of lower postoperative opioid consumption included higher quantitative (P = .047) and qualitative (P = .005) pain tolerance scores. Multivariate analysis for the entire cohort demonstrated that higher qualitative pain threshold was associated with lower postoperative opioid consumption (P = .005) but this did not meet statistical significance as an independent predictor of the top quartile of pill consumers. Conclusion: Assessment of both qualitative and quantitative score of patients’ pain threshold prior to surgery may assist the surgeon in tailoring postoperative pain control. Additionally, asking this question can create an opportunity for educating patients regarding responsible utilization of narcotic medication. Levels of Evidence: Level III
Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats

Antarctic krill oil (KO) prepared using supercritical carbon dioxide extraction and characterized using gas chromatography-mass spectrometry was used to investigate its preventive effect on ethanol-induced gastric tissue damage in a rat model in vivo. KO characterization showed that 74.96% of the unsaturated fatty acids consist of oleic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Rats pre-treated with KO (100, 200, and 500 mg/kg) showed mitigated oxidative stress through enhanced antioxidant enzyme superoxide dismutase (SOD) and reducing enzymes malondialdehyde (MDA) and myeloperoxidase (MPO) in gastric mucosal injury induced by ethanol. Additionally, the secretion of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), the expression of the IκBα/NF-κB signaling pathway, and nitric oxide (NO) production was suppressed. The results also demonstrated a significant decrease in histological injury and hemorrhage scores in a dose-dependent manner in the KO range. Therefore, KO has potential as a food supplement to alleviate ethanol-induced acute gastric mucosal injury. Graphical Abstract The work flow and the main findings of the KO modulatory effects.
Is honesty the best policy for mismatched partners? Aligning multi-modal affordances of a social robot: An opinion paper

Spoken interactions between a human user and an artificial device (such as a social robot) have attracted much attention in recent decades (Lison and Meena, 2014; Oracle, 2020). Shifting from automation robots in the industrial domain, social robots are expected to be used in social domains, such as the service industry, education, healthcare, and entertainment (Bartneck et al., 2020, p.163). According to Darling (2016)’s definition, a social robot is “a physically embodied, autonomous agent that communicates and interacts with humans on an emotional level”. Many features play important roles in interactions with a social robot, such as people’s experience with technology products, expectations of social robots, interactional environments and other features such as a social robot’s appearance, voice and behaviours. In this last regard, affordance design affects how people perceive a social robot and how such perception affects their behaviours and experiences. The term “affordance” was invented by ecological psychologist Gibson (1977), who proposed that our perception of what it is possible to do with objects is shaped by their form. Affordance indicates what users see and can do with an object in a given situation; it is about perceptual action possibilities in an environment (Matei, 2020). A strong tendency in social robot affordance design is to make human-robot interaction (HRI) resemble human-human interaction (HHI). It is hoped in many studies that robots designed with anthropomorphic appearances and human-like cognitive behaviours can enable humans to interact with them in similar ways as they would interact with other humans, even to develop social bonds (Leite et al., 2013; Kahn et al., 2015; Koyama et al., 2017; Ligthart et al., 2018). However, there are concerns about this approach. In fact, speech-based artificial agents’ conversational interaction with human users is far from natural, and the language used tends to be formulaic (Moore et al., 2016). One of the reasons behind this is a significant change in the applications of spoken human-agent interaction (HAI) along the evolution of spoken language technology applications (Moore, 2017a). Compared with “command and control systems” of the 1970s and contemporary smartphone-based “personal assistants”, social robots are expected to be used in more dynamic and open environments. This implies that users’ expectations, demands and ways to interact with spoken agents differ OPEN ACCESS
Tuning Rex rules HTLV-1 pathogenesis

HTLV-1 is an oncovirus causing ATL and other inflammatory diseases such as HAM/TSP and HU in about 5% of infected individuals. It is also known that HTLV-1-infected cells maintain a disease-free, immortalized, latent state throughout the lifetimes of about 95% of infected individuals. We believe that the stable maintenance of disease-free infected cells in the carrier is an intrinsic characteristic of HTLV-1 that has been acquired during its evolution in the human life cycle. We speculate that the pathogenesis of the virus is ruled by the orchestrated functions of viral proteins. In particular, the regulation of Rex, the conductor of viral replication rate, is expected to be closely related to the viral program in the early active viral replication followed by the stable latency in HTLV-1 infected T cells. HTLV-1 and HIV-1 belong to the family Retroviridae and share the same tropism, e.g., human CD4+ T cells. These viruses show significant similarities in the viral genomic structure and the molecular mechanism of the replication cycle. However, HTLV-1 and HIV-1 infected T cells show different phenotypes, especially in the level of virion production. We speculate that how the activity of HTLV-1 Rex and its counterpart HIV-1 Rev are regulated may be closely related to the properties of respective infected T cells. In this review, we compare various pathological aspects of HTLV-1 and HIV-1. In particular, we investigated the presence or absence of a virally encoded “regulatory valve” for HTLV-1 Rex or HIV-1 Rev to explore its importance in the regulation of viral particle production in infected T cells. Finally, wereaffirm Rex as the key conductor for viral replication and viral pathogenesis based on our recent study on the novel functional aspects of Rex. Since the activity of Rex is closely related to the viral replication rate, we hypothesize that the “regulatory valve” on the Rex activity may have been selectively evolved to achieve the “scenario” with early viral particle production and the subsequent long, stable deep latency in HTLV-1 infected cells.
Comparative chloroplast genome analysis of Ficus (Moraceae): Insight into adaptive evolution and mutational hotspot regions

As the largest genus in Moraceae, Ficus is widely distributed across tropical and subtropical regions and exhibits a high degree of adaptability to different environments. At present, however, the phylogenetic relationships of this genus are not well resolved, and chloroplast evolution in Ficus remains poorly understood. Here, we sequenced, assembled, and annotated the chloroplast genomes of 10 species of Ficus, downloaded and assembled 13 additional species based on next-generation sequencing data, and compared them to 46 previously published chloroplast genomes. We found a highly conserved genomic structure across the genus, with plastid genome sizes ranging from 159,929 bp (Ficus langkokensis) to 160,657 bp (Ficus religiosa). Most chloroplasts encoded 113 unique genes, including a set of 78 protein-coding genes, 30 transfer RNA (tRNA) genes, four ribosomal RNA (rRNA) genes, and one pseudogene (infA). The number of simple sequence repeats (SSRs) ranged from 67 (Ficus sagittata) to 89 (Ficus microdictya) and generally increased linearly with plastid size. Among the plastomes, comparative analysis revealed eight intergenic spacers that were hotspot regions for divergence. Additionally, the clpP, rbcL, and ccsA genes showed evidence of positive selection. Phylogenetic analysis indicated that none of the six traditionally recognized subgenera of Ficus were monophyletic. Divergence time analysis based on the complete chloroplast genome sequences showed that Ficus species diverged rapidly during the early to middle Miocene. This research provides basic resources for further evolutionary studies of Ficus.
A comprehensive phytochemical, biological, and toxicological studies of roots and aerial parts of Crotalaria burhia Buch.-Ham: An important medicinal plant

This study was designed to seek the phytochemical analysis, antioxidant, enzyme inhibition, and toxicity potentials of methanol and dichloromethane (DCM) extracts of aerial and root parts of Crotalaria burhia. Total bioactive content, high-performance liquid chromatography-photodiode array detector (HPLC-PDA) polyphenolic quantification, and ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) analysis were utilized to evaluate the phytochemical composition. Antioxidant [including 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH)], 2,2′-azino-bis[3-ethylbenzothiazoline-6-sulfonic acid (ABTS), ferric reducing antioxidant power assay (FRAP), cupric reducing antioxidant capacity CUPRAC, phosphomolybdenum, and metal chelation assays] and enzyme inhibition [against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-glucosidase, α-amylase, and tyrosinase] assays were carried out for biological evaluation. The cytotoxicity was tested against MCF-7 and MDA-MB-231 breast cell lines. The root-methanol extract contained the highest levels of phenolics (37.69 mg gallic acid equivalent/g extract) and flavonoids (83.0 mg quercetin equivalent/g extract) contents, and was also the most active for DPPH (50.04 mg Trolox equivalent/g extract) and CUPRAC (139.96 mg Trolox equivalent /g extract) antioxidant assays. Likewise, the aerial-methanol extract exhibited maximum activity for ABTS (94.05 mg Trolox equivalent/g extract) and FRAP (64.23 mg Trolox equivalent/g extract) assays. The aerial-DCM extract was noted to be a convincing cholinesterase (AChE; 4.01 and BChE; 4.28 mg galantamine equivalent/g extract), and α-glucosidase inhibitor (1.92 mmol acarbose equivalent/g extract). All of the extracts exhibited weak to modest toxicity against the tested cell lines. A considerable quantities of gallic acid, catechin, 4-OH benzoic acid, syringic acid, vanillic acid, 3-OH-4-MeO benzaldehyde, epicatechin, p-coumaric acid, rutin, naringenin, and carvacrol were quantified via HPLC-PDA analysis. UHPLC-MS analysis of methanolic extracts from roots and aerial parts revealed the tentative identification of important phytoconstituents such as polyphenols, saponins, flavonoids, and glycoside derivatives. To conclude, this plant could be considered a promising source of origin for bioactive compounds with several therapeutic uses.
Visible gland constantly traces virus-induced gene silencing in cotton

A virus-induced gene silencing (VIGS) system was established to induce endogenous target gene silencing by post-transcriptional gene silencing (PTGS), which is a powerful tool for gene function analysis in plants. Compared with stable transgenic plant via Agrobacterium-mediated gene transformation, phenotypes after gene knockdown can be obtained rapidly, effectively, and high-throughput through VIGS system. This approach has been successfully applied to explore unknown gene functions involved in plant growth and development, physiological metabolism, and biotic and abiotic stresses in various plants. In this system, GhCLA1 was used as a general control, however, silencing of this gene leads to leaf albino, wilting, and plant death ultimately. As such, it cannot indicate the efficiency of target gene silencing throughout the whole plant growth period. To address this question, in this study, we developed a novel marker gene, Gossypium PIGMENT GLAND FORMATION GENE (GoPGF), as the control to trace the efficiency of gene silencing in the infected tissues. GoPGF has been proved a key gene in gland forming. Suppression of GoPGF does not affect the normal growth and development of cotton. The number of gland altered related to the expression level of GoPGF gene. So it is a good marker that be used to trace the whole growth stages of plant. Moreover, we further developed a method of friction inoculation to enhance and extend the efficiency of VIGS, which facilitates the analysis of gene function in both the vegetative stage and reproductive stage. This improved VIGS technology will be a powerful tool for the rapid functional identification of unknown genes in genomes.
Smart breeding approaches in post-genomics era for developing climate-resilient food crops

Improving the crop traits is highly required for the development of superior crop varieties to deal with climate change and the associated abiotic and biotic stress challenges. Climate change-driven global warming can trigger higher insect pest pressures and plant diseases thus affecting crop production sternly. The traits controlling genes for stress or disease tolerance are economically imperative in crop plants. In this scenario, the extensive exploration of available wild, resistant or susceptible germplasms and unraveling the genetic diversity remains vital for breeding programs. The dawn of next-generation sequencing technologies and omics approaches has accelerated plant breeding by providing the genome sequences and transcriptomes of several plants. The availability of decoded plant genomes offers an opportunity at a glance to identify candidate genes, quantitative trait loci (QTLs), molecular markers, and genome-wide association studies that can potentially aid in high throughput marker-assisted breeding. In recent years genomics is coupled with marker-assisted breeding to unravel the mechanisms to harness better better crop yield and quality. In this review, we discuss the aspects of marker-assisted breeding and recent perspectives of breeding approaches in the era of genomics, bioinformatics, high-tech phonemics, genome editing, and new plant breeding technologies for crop improvement. In nutshell, the smart breeding toolkit in the post-genomics era can steadily help in developing climate-smart future food crops.
Adaptation of the 5-choice serial reaction time task to measure engagement and motivation for alcohol in mice

Alcohol use disorder (AUD) is related to excessive binge alcohol consumption, and there is considerable interest in associated factors that promote intake. AUD has many behavioral facets that enhance inflexibility toward alcohol consumption, including impulsivity, motivation, and attention. Thus, it is important to understand how these factors might promote responding for alcohol and can change after protracted alcohol intake. Previous studies have explored such behavioral factors using responding for sugar in the 5-Choice Serial Reaction Time Task (5-CSRTT), which allows careful separation of impulsivity, attention, and motivation. Importantly, our studies uniquely focus on using alcohol as the reward throughout training and testing sessions, which is critical for beginning to answer central questions relating to behavioral engagement for alcohol. Alcohol preference and consumption in male C57BL/6 mice were determined from the first 9 sessions of 2-h alcohol drinking which were interspersed among 5-CSRTT training. Interestingly, alcohol preference but not consumption level significantly predicted 5-CSRTT responding for alcohol. In contrast, responding for strawberry milk was not related to alcohol preference. Moreover, high-preference (HP) mice made more correct alcohol-directed responses than low-preference (LP) during the first half of each session and had more longer reward latencies in the second half, with no differences when performing for strawberry milk, suggesting that HP motivation for alcohol may reflect “front-loading. ” Mice were then exposed to an Intermittent Access to alcohol paradigm and retested in 5-CSRTT. While both HP and LP mice increased 5-CSRTT responding for alcohol, but not strawberry milk, LP performance rose to HP levels, with a greater change in correct and premature responding in LP versus HP. Overall, this study provides three significant findings: (1) alcohol was a suitable reward in the 5-CSRTT, allowing dissection of impulsivity, attention, and motivation in relation to alcohol drinking, (2) alcohol preference was a more sensitive indicator of mouse 5-CSRTT performance than consumption, and (3) intermittent alcohol drinking promoted behavioral engagement with alcohol, especially for individuals with less initial engagement.