Miracle-dz/UniFAR-FTUs huggingface dataset:
Scalable Testing of Mobile Antivirus Apps

Scientiﬁc evaluation of antivirus applications is a long-debated problem. Es-sentially, reproducing the same exact conditions an antivirus meets when running on a user’s device presents conﬂicting requirements, which in the mobile world are exacerbated even further. We implemented AndroTotal, a scalable system to conduct mobile antivirus evaluations with a rigorous approach. It is a publicly available service and open research dataset that we operate since early 2013. We describe the conceptual and technical challenges that we faced in its design and implementation, and compare it against existing approaches. Furthermore, we report our experience after one year of operation and data collection.
A linear phase IIR filterbank for the radial filters of ambisonic recordings

Higher order ambisonics involve excessive bass boosts, especially for high orders and at low frequencies. In order to avoid unnecessary and excessive ampliﬁcation for components that do not contribute signiﬁcantly to the sound-ﬁeld, a ﬁlterbank can be used in order to cut-off noise ampliﬁcation. In the present paper, we propose a linear phase IIR ﬁlterbank implementation that allows to avoid the used of fast block convolutions or nonlinear IIR ﬁlters. Our approach is based on local overlap-add time reversed block convolutions, which allow the ﬁlterbank to exhibit a linear delay, which only depends on the sectioned block size. When combined with radial ﬁlters of a rigid spherical recording array, this approach allows to change the cutoff frequencies of the ﬁlterbank with more ﬂexibility than pre-computed FIR ﬁlterbanks.
Title: POSTPRANDIAL CHANGES IN GASTROINTESTINAL FUNCTION AND TRANSIT IN CYSTIC FIBROSIS ASSESSED BY MAGNETIC RESONANCE IMAGING

Cystic fibrosis (CF) is a multi-system genetic disorder affecting >72,000 people worldwide. Most CF patients experience gastrointestinal symptoms and can develop complications. However, the mechanisms of CF gut disease are not well understood. We evaluated gut function and transit in CF using magnetic resonance imaging (MRI). We hypothesised oro-caecal transit time (OCTT) is longer in CF; with lower small bowel water content (SBWC). Twelve CF patients aged 12-40 years and 12 age and sex-matched controls underwent serial MRIs over 1 day with standardised meals. The primary endpoint was OCTT, assessed by the appearance of a food bolus in the caecum. Other measures included corrected SBWC and corrected colonic volume (both area under the curve, AUC), gastric half-emptying time and gastrointestinal symptoms.
Non-Obviousness and Complementary Innovations

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Non-Obviousness and Complementary Innovations Yann Ménière
Market shaping and systemic innovation

In this special section of the Journal of Business & Industrial Marketing , we introduce the ﬁ ve accepted papers that all present their own perspectives on the connection between systemic innovation and market shaping. The papers build on an amalgamation of extant literature and empirical research and collectively provide a basis for a research agenda on market-shaping strategies, especially regarding business and industrial marketing.
OTT_A_248925 8079..8094

1Department of Thoracic and Abdominal Radiotherapy, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 2Clinical Laboratory, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, People’s Republic of China Introduction: Esophageal squamous cell carcinoma (ESCC) is a malignant tumor disease with high mortality and morbidity rates, especially for a terminal cancer. At present, the prognosis and treatment of ESCC cannot effectively control or inhibit the spread and proliferation of tumor cells. microRNAs, a class of small spliced RNAs, are essential in the regulation of tumorigenesis and tumor cell migration and proliferation. microRNAs interact with target mRNA to silence gene expression and degrade mRNA, thereby inhibiting the expression of tumor genes or impairing the expression of tumor suppressor genes. Methods: A total of 20 human ESCC samples were collected from the Affiliated Tumor Hospital of Xinjiang Medical University. Eca109 and Kyse510 cells, which are ESCC cell lines, were subjected to FACS analysis to get side population (SP) cells and non-SP cells. Cell cycle and cell proliferation were analyzed by flow cytometry. Cell migration and invasion were detected using a transwell assay. Quantitative PCR and Western blot were performed to analyze the expression levels of ABCG2, KLF4, OCT4, and ACVR1, which are related to the stemness of stem cells. The target genes of hsa-miR-148a were predicted using TargetScan (version 7.2) and verified by a dual luciferase reporter assay. A chromatin immunoprecipitation (ChIP) assay was carried out to demonstrate direct interaction between miR-148a and ACVR1. Results: The expression of miR-148a was significantly down-regulated in ESCC cells and significantly decreased in SP esophageal squamous cells when compared to the tumor cells. By analyzing the stem cell stemness of ESCC, overexpression of miR-148a decreased the expression of ABCG2, KLF4, SOX2, OCT4, and Nanog, indicating that miR-148a may regulate stem cell function. Target gene prediction and functional annotation of miR-148a suggested that miR-148a is involved in stem cell stemness of ESCC via ACVR1. Expression of the dual luciferase-labeled gene indicates that overexpression of miR-148a inhibits the expression of ACVR1, thereby affecting stem cell stemness. Conclusion: miR-148a regulates the stem cell-like side populations distribution by inhibiting the expression of ACVR1 in ESCC. miR-148a may be a promising targeted therapy for ESCC.
Identifying the functional pathways and potential genes associated with interferon signaling during human adenovirus type 7 (HAdV-7) by weighted gene co-expression network analysis

Background Human adenovirus type 7 (HAdV-7) can cause severe pneumonia in children and severe complications. At present, however, the pathogenesis and genes involved remain largely unknown. Methods We collected HAdV-7 infected and mock-infected A549 cells at 24, 48, and 72 hours post-infection (hpi) for RNA sequencing (RNA-seq). And, we identified potential genes and functional pathways associated with HAdV-7 infection using weighted gene co-expression network analysis (WGCNA). Results Based on bioinformatics analysis, 12 co-expression modules were constructed by WGCNA, with the blue, tan, and brown modules significantly positively correlated with Ad-24 hpi, Ad-48 hpi, and Ad-72 hpi, respectively. Functional enrichment analysis indicated that the blue module was mainly enriched in DNA replication, cell cycle, and viral process; the tan module was largely enriched in metabolic pathways and regulation of superoxide radical removal; and the brown module was predominantly enriched in mitochondrial respiratory chains and regulation of cell death. Quantitative polymerase chain reaction (qPCR) was used to determine transcript abundance of some identified hub genes, and results were consistent with those from RNA-seq. Based on comprehensive analysis of hub genes and differentially expressed genes (DEGs) in the GSE68004 dataset, we identified SOCS3, OASL, ISG15, and IFIT1 as potential candidate genes for biomarkers or drug targeting in HAdV-7 infection. Further, we propose a multi-target inhibition of interferon signaling mechanism to explain the HAdV-7 associated with higher severity of clinical consequences. Conclusions We constructed a framework of co-expression gene modules from A549 cells infected with HAdV-7, thus providing a basis for identifying potential genes and pathways involved in adenovirus infection and for studying the pathogenesis of adenoviruses.
Method of Dynamically Determining the Nodes that Hold Advertisements Suitable for the User’s Preference and a Relay Routing Method Based on Area Division

—Mobile communications carriers are providing GPS-based, location-dependent advertisement delivery services as supplementary services. As the number of mobile terminal types and the number of mobile users increase, the need is rising for a network that can handle location-dependent traffic within a locality efficiently. This paper presents an ad hoc network for location-oriented advertisement delivery, with an advertising node installed in each shop in a busy shopping area. Specifically, it describes a way to express the user’s preference, such as their hobbies, based on a Bloom Filter, and a way to dynamically determine the nodes that hold advertisements suitable for the preference of the target user. In addition, the paper also presents a routing method based on area division, which can reduce the number of relay nodes. It has been confirmed, by using simulation, that the proposed method reduces the number of relay nodes by about 70% compared with a case where messages are unicast to collect suitable advertisements.
Ecofriendly Organosolv Process for Pulping of Tender Coconut Fibre

The huge biomass generated by vendors of tender coconut is the broken husks refuse dumped along roads and highways in Kerala. These dumps become breeding grounds for diseased causing germs and carrier mosquitoes causing threat to human life. In order to avoid pollution and find use of the rejected biomass of tender husks, a study was carried out on pulping of tender coconut husk fibre which could be used for papermaking. The optimum pulping condition, the quality of the pulp and its yield was evaluated using different variables like time and temperature. It was observed that the organosolv process could efficiently remove lignin from the tender coconut fibre yielding maximum cellulose. During the traditional pulping processes such as Kraft pulping to isolate the cellulose fibers for the production of paper, the hemicellulose and lignin fractions are degraded, limiting their valorization possibilities. Organosolv pulping has been advocated as the environmentally benign version of the kraft process. Unlike other pretreatment methods, organic solvents can easily be recycled and reused. The lignin dissolved by organosolv pulping is easily recovered by dilution and is unsulphonated and relatively unmodified. Products like handmade paper, egg cartons, handicraft items, garden articles like paper pots could be made from the organasolv pulp of tender coconut husk fibre.
Induction Motors Fault Detection Using Square-Root Transformed Cubature Quadrature Kalman Filter

This paper proposes a novel approach for simultaneous state estimation and broken rotor bars (BRBs) detection in induction motors. The proposed method is named square-root transformed cubature quadrature Kalman filter (SR-TCQKF). The accuracy of the filter has been improved by a transformation on the filter's sigma points, whereas the filter becomes more stable due to the use of the SR version of the covariance matrix. Accordingly, the SR-TCQKF is more accurate and stable than the standard cubature quadrature Kalman filter. The efficiency of the SR-TCQKF has been evaluated for speed estimation and BRB detection in induction motors. The attained results show the efficiency of the proposed approach.
Reduced mutual coupling of compact MIMO antenna designed for WLAN and WiMAX applications

This communication describes a simple compact wide band multiple input multiple output (MIMO) antenna for Wireless Local Area Network (WLAN) and Worldwide Interoperability for Microwave Access (WiMAX) applications. The proposed antenna is integrated with an electromagnetic band gap (EBG) structure which is used to reduce the mutual coupling between the ports. The structure is excited by a line feed mechanism and investigated experimentally. The antenna covers the frequency range from 2.01 to 3.92 GHz with the corresponding fractional bandwidth of 64.42%. It fulfills the bandwidth requirements of WLAN (2.35‐2.5 GHz) and WiMAX (3.2‐3.85 GHz) bands where minimum port isolation is obtained around 29 dB throughout the entire application band. The proposed MIMO antenna has very low envelope correlation co‐efficient (ECC < 0.01) and high diversity gain (DG > 9.8). It also has very low channel capacity loss (CCL) which is found to be less than 0.2 Bit/s/Hz. The simulation results are compared with the measurement outcomes and found a good agreement between them.
Systemic Immune-Inflammation Index Predicts 3-Month Functional Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis

Background and Purpose: Systemic immune-inflammation index (SII), a novel inflammation index derived from counts of circulating platelets, neutrophils and lymphocytes, has been studied in developing incident cancer. However, the clinical value of SII in acute ischemic stroke (AIS) patients had not been further investigated. Therefore, we aimed to explore the association between SII and severity of stroke as well as 3-month outcome of AIS patients. Methods: A total of 216 AIS patients receiving intravenous thrombolysis (IVT) and 875 healthy controls (HCs) were retrospectively recruited. Blood samples were collected within 24h after admission. Severity of stroke was assessed by the National Institute of Health stroke scale (NIHSS) scores on admission and poor 3-month functional outcome was defined as Modified Rankin Scale (mRS) > 2. Results: SII levels in AIS patients were higher than in HCs. The cut-off value of SII is 545.14×10 9 /L. Patients with SII > 545.14×10 9 /L had higher NIHSS scores (median: 5 vs 9, p < 0.001), a positive correlation between SII and NIHSS was observed ( rs = 0.305, p < 0.001). Multivariate logistic regression analyses showed that high SII was one of the independent risk factors for poor prognosis at 3 months of AIS patients (OR = 3.953, 95% CI = 1.702–9.179, p = 0.001). The addition of SII to the conventional prognostic model improved the reclassification (but not discrimination) of the functional outcome (net reclassification index 39.3%, p = 0.007). Conclusion: SII is correlated with stroke severity at admission and can be a novel prognostic biomarker for AIS patients treated with IVT.
‘That would have been beneficial’: LGBTQ education for home-care service providers

This paper reports qualitative findings from a pilot study that explored the lesbian, gay, bisexual, transgender and queer (LGBTQ) education needs of home-care service providers working in one large, urban Canadian city. The pilot study builds upon research that has documented barriers to health services for diversely situated LGBTQ people, which function to limit access to goodquality healthcare. LGBTQ activists, organisations and allies have underscored the need for health provider education related to the unique health and service experiences of sexual and gender minority communities. However, the home-care sector is generally overlooked in this important body of research literature. We used purposeful convenience sampling to conduct four focus groups and two individual interviews with a total of 15 professionally diverse homecare service providers. Data collection was carried out from January 2011 to July 2012 and data were analysed using grounded theory methods towards the identification of the overarching theme, ‘provider education’ and it had two sub-themes: (i) experiences of LGBTQ education; and (ii) recommendations for LGBTQ education. The study findings raise important questions about limited and uneven access to adequate LGBTQ education for home-care service providers, suggest important policy implications for the education and health sectors, and point to the need for anti-oppression principles in the development of education initiatives.
Metabolism of 17/j-Estradiol during Receptor-mediated Nuclear Migration in Breast Cancer Cells1

The fate of tritiated 17/i-estradiol in MCF-7 cells was followed at various times during incubation at 0 and 37Â°. in the cold incubations 17/i-estradiol (2 x 10" M) was rapidly taken into the cells and oxidized to estrone, and both estrogens were bound to high-affinity, low-capacity sites in the cytosol. Also at 0Â°17/J-estradiol was found bound to receptor in the 0.4 M KCI extract of nuclei centrifuged through 2.2 M sucrose. In addition, 17/i-estra diol and estrone comprise the non-salt-extractable estro gens in these purified nuclei. Removing the exogenous tritiated 17/i-estradiol and warming the cells to 37Â°resulted in the migration of cytosolic 17/3-estradiol:receptor complex into the nucleus and in the formation of additional receptor-bound estrone in both the cytosol and nucleus. These time-related in creases in bound estrone were not associated with the total cytoplasmic estrone, which remained a consistent 7.2 Â±2.8% (S.D.) of the cellular estrogen during the 1 hr at 37Â°. The data indicate that, in MCF-7 cells, estrone is readily formed from 17/i-estradiol even at 0Â°and estrone is bound with high affinity to a cytosolic macromolecule in the presence of a 10-fold intracellular excess of 17/i-estradiol.
University of Birmingham Coordination of the upper and lower limbs for vestibular control of balance

sway These results demonstrate that a minimum level of grip is required before the upper limb becomes active in balance control and also that the upper and lower limbs co-ordinate for an appropriate whole-body sway response. Abstract Vestibular stimulation can evoke responses in the arm when it is used for balance. In the present study, we determined how these responses are affected by grip context, as well as how they are co-ordinated with the rest of the body. Galvanic vestibular stimulation (GVS) was used to evoke balance responses under three conditions of manual contact with an earth-ﬁxed object: no contact, light grip ( < 1 N) (LG) and ﬁrm grip (FG). As grip progressed along this continuum, we observed an increase in GVS-evoked hand force, with a simultaneous reduction in ground reaction force (GRF) through the feet. During LG, hand force was secondary to the GVS-evoked body sway response, indicating that the arm performed a mostly passive role. By contrast, during FG, the arm became actively involved in driving body sway, as revealed by an early force impulse in the opposite direction to that seen in LG. We then examined how the direction of this active hand vector was co-ordinated with the lower limbs. Consistent with previous ﬁndings on sway anisotropy, FG skewed the direction of the GVS-evoked GRF vector towards the axis of baseline postural instability. However, this was effectively cancelled by the hand force vector, such that the whole-body sway response remained aligned with the inter-aural axis, maintaining the craniocentric principle. These results show that a minimum level of grip is necessary before the upper limb plays an active role in vestibular-evoked balance responses. Furthermore, they demonstrate that upper and lower-limb forces are co-ordinated to produce an appropriate whole-body sway response.
Worldsheet correlators in AdS 3 /CFT 2

: The AdS 3 /CFT 2 correspondence is checked beyond the supergravity approximation by comparing correlation functions. To this end we calculate 2- and 3-point functions on the sphere of certain chiral primary operators for strings on AdS 3 × S 3 × T 4 . These results are then compared with the corresponding amplitudes in the dual 2-dimensional conformal ﬁeld theory. In the limit of small string coupling, where the sphere diagrams dominate the string perturbation series, beautiful agreement is found.
Palliative Radiation Treatment for Previously Untreated Head and Neck Cancer - Why, When and How: A Comprehensive Review

Currently, there are no evidence-based guidelines regarding palliative radiation for untreated head and neck squamous cell carcinoma (HNSCC) patients who are ineligible for curative treatment. This article reviews the available literature for palliative head and neck radiotherapy. The life expectancy and performance status of patients are used to optimize the treatment recommendations.
Individual, Local, and Size-dependent Variations in Toxicity of the Xanthid Crab Zosimus aeneus

A total of 119 specimens of the xanthid crab Zosimus aeneus were collected from Ishigaki Island•@ (102),Hachijo Island•@ (1),the Bonin Islands•@ (5), and Cebu Island in the Philippines (11) from 1979 through 1982, and assayed for toxicity by mouse assay. The results showed that almost all the specimens were toxic, except a single specimen from Ishigaki Island. A remarkable individual variation of toxicity was observed among the specimens collected from a given locality, even among those from a narrow area. The local variation in toxicity was also large. Ishigaki specimens generally showed higher toxicity scores than those from other localities, the highest score recorded being 16,500MU/g. There was a tendency that the toxicity is higher in specimens less than 60g in body weight than in larger ones. No significant differences in toxicity were observed between sexes and between years of collection.
Semiconductor physics Preparation of quaternary compounds Cu 2 ZnSnS 4 by using the self-propagating high-temperature synthesis

Possibility to prepare finely dispersed Cu 2 ZnSnS 4 by using the method of self-propagating high-temperature synthesis has been studied in this work. Investigations of Raman scattering and IR-Fourier spectroscopy of the synthesized finely dispersed material have been carried out. The analysis of the Raman and IR-Fourier spectra showed that the synthesized material in the process of preparing is formed with a kesterite structure with the inclusion of a certain amount of secondary phases in the form of sulfides and stannites.
CMAR_A_249237 3285..3291

Cheng Xue Yi Cheng Jinyou Wu Kongliang Ke Chundi Miao Enfu Chen Luqing Zhang 1Department of Endocrinology, Wenling First People’s Hospital, Wenling 317500, People’s Republic of China; 2Department of Anorectal Surgery, Ningbo Hangzhou Bay Hospital, Ningbo 315000, People’s Republic of China Background: The role of circular RNA (circRNA) in papillary thyroid cancer (PTC) is largely unknown. This study aims to determine the function and mechanism of circPRMT5 in the regulation of PTC development. Methods: PTC tissues and cell lines were used to determine circPRMT5 expression via quantitative real-time polymerase chain reaction. Small interfering RNA (siRNA) was utilized to knock down circPRMT5. Proliferation was analyzed through CCK8 and colony formation assays. Transwell assay was performed to determine cell migration and invasion. Luciferase assay and RIP assay were carried out to analyze the interaction between circPRMT5 and miR-30c. Results: CircPRMT5 expression was upregulated in PTC tissues and cell lines. And circPRMT5 level was positively linked with advanced stage and lymph node metastasis. CircPRMT5 knockdown inhibited proliferation, migration and invasion while inducing apoptosis. CircPRMT5 worked as a competing endogenous RNA for miR-30c. By inhibiting miR-30c, circPRMT5 promoted the expression of E2F3. Conclusion: Our findings demonstrate that circPRMT5 acts as an oncogenic circRNA to promote PTC progression via regulating miR-30c/E2F3 axis.