Miracle-dz/UniFAR-FTUs huggingface dataset:
A retrospective observational study of patient analgesia outcomes when regional anaesthesia procedures are performed by consultants versus supervised trainees

At teaching hospitals, consultants must provide effective supervision, including appropriate selection of teaching cases, such that the outcomes achieved by trainees are similar to that of consultants. Numerous studies in the surgical literature have compared patient outcomes when surgery is performed by consultant surgeons or surgical trainees but, to our knowledge, none exist in the field of anaesthesia. We aimed to compare analgesia outcomes of regional anaesthesia when performed by supervised trainees versus consultants. We designed a retrospective observational study using registry data. The primary outcome was inadequate analgesia, defined as a numerical rating scale (NRS) for pain >5 reported at any time in the post-anaesthesia care unit (PACU). Secondary outcomes included the maximum pain NRS, pain experienced in the PACU, and the requirement for systemic opioid analgesia in the PACU. Of the 1814 patients analysed, the primary proceduralist was a consultant for 514 (28.3%) patients and a trainee for 1300 (71.7%) patients. All trainees were supervised by an on-site consultant. There were no statistically significant differences between consultants and supervised trainees in terms of the primary outcome (NRS >5 in 24.9% and 24.5% of patients, respectively; P = 0.84) and secondary outcomes. Compared to trainees, consultants had a slightly higher rate of patients with a body mass index >30 kg/m2, an American Society of Anesthesiologists Physical Status Classification of 3 or 4, nerve blocks performed under general anaesthesia, paravertebral/neuraxial blocks and blocks with perineural catheter placement. Regional anaesthesia performed by supervised trainees can achieve similar analgesia outcomes to consultant-performed procedures.
Prevalence of Frailty and Associated Factors Among Hospitalized Older Adults: A Cross-Sectional Study

This study aimed to estimate the prevalence of frailty and associated factors among hospitalized older adults. It consisted of 184 hospitalized older adults recruited between October 2019 to January 2020. We used the FRAIL scale, Geriatric Depression Scale–15, and the Pittsburg Sleep Quality Index to collect data. Descriptive statistics, independent group t-test, Chi-square (χ2) tests, and logistic regression were applied to statistical analysis. It found that the prevalence of frailty among hospitalized older adults was 39.7%. Depression (Mild: OR = 5.312, 95% CI [2.384–11.833]; Moderate: OR = 6.630, 95% CI [2.077–21.160]) and low activities of daily living (ADL) (Slight dependence: OR = 5.667, 95% CI [1.308–24.557]; Moderate dependence: OR = 15.188, 95% CI [3.342–69.016]; Severe dependence: OR = 5.872, 95% CI [2.645–13.038]) were independent predictors of frailty. Future studies on the interventions to reduce depression, improve ADL and delay the progression of frailty are encouraged. We should focus more on ADL, emotional and psychological state of hospitalized older adults to prevent frailty.
Oral Health Equity Must Address Oppression: On the BSSOH Consensus Statement

The Consensus Statement on Future Directions for the Behavioral and Social Sciences in Oral Health (Consensus Statement) is a transformational contribution to oral health research synthesizing a wide array of conceptual, methodological, and disciplinary concerns and offering strategies to improve scientific inquiry. The Consensus Statement explicates global oral health equity as a foundational concern of our field. Given this context, a key concern is missing from the statement: oppression!
Using the lactate-to-albumin ratio to predict mortality in patients with sepsis or septic shock: a systematic review and meta-analysis.

OBJECTIVE This study aimed to investigate whether the lactate-to-albumin ratio (LAR) can predict mortality in patients with sepsis or septic shock. PATIENTS AND METHODS A systematic search of the PubMed, EMBASE, Web of Science, and Google Scholar databases was conducted on December 16, 2021, for relevant articles that provided the predictive performance of LAR for mortality in patients with sepsis or septic shock. RESULTS Eight studies encompassing a total of 4,723 patients were included in this paper. The pooled sensitivity, specificity, and diagnostic odds ratio of the LAR for predicting mortality were 0.71 (95% confidence interval [CI]: 0.54-0.84), 0.68 (95% CI: 0.58-0.76) and 5.23 (95% CI: 2.62-10.45), respectively. The area under the summary receiver operating characteristic curve was 0.74 (95% CI: 0.70-0.78). CONCLUSIONS The current evidence suggests that LAR is moderately predictive of mortality among patients with sepsis or septic shock and may be beneficial to identify high-risk patients.
New Phase-Vocoder Techniques are Real-Time Pitch Shifting, Chorusing, Harmonizing, and Other Exotic Audio Modifications

The phase vocoder is a well-established tool for time-scaling and pitch shifting speech and audio signals. Its theory is now well understood and improvements have been proposed to reduce artifacts commonly encountered when time expanding signals by large factors. In the literature the phase vocoder has been described primarily as a tool for time scaling rather than pitch shifting, the latter usually being achieved by a combination of time scaling and sampling-rate conversion. The authors focus mainly on pitch-scale modifications of speech and audio signals and discuss the drawbacks of the standard time-scaling and resampling technique. Two alternative techniques are presented which reduce the complexity and computational cost significantly while offering dramatically extended capabilities. In particular, the new techniques, which operate solely in the frequency domain, enable chorusing, harmonizing, and nonstandard frequency modifications such as partial stretching (nonlinear frequency saling), frequency inversions, and so on.
Mechanistic insight on boron-mediated toxicity in plant vis-a-vis its mitigation strategies: a review

Abstract Boron (B) is an essential micronutrient, crucial for the growth and development of crop plants. However, the essential to a toxic range of B in the plant is exceptionally narrow, and symptoms develop with a slight change in its concentration in soil. The morphological and anatomical response, such as leaf chlorosis, stunted growth, and impairment in the xylem and phloem development occurs under B-toxicity. The transport of B in the plant occurs via transpiration stream with the involvement of B-channels and transporter in the roots. The higher accumulation of B in source and sink tissue tends to have lower photosynthetic, chlorophyll content, infertility, failure of pollen tube formation and germination, impairment of cell wall formation, and disruption of membrane systems. Excess B in the plant hinders the uptake of other micronutrients, hormone transport, and metabolite partitioning. B-mediated reactive oxygen species production leads to the synthesis of antioxidant enzymes which help to scavenge these molecules and prevent the plant from further oxidative damage. This review highlights morpho-anatomical, physiological, biochemical, and molecular responses of the plant under B toxicity and thereby might help the researchers to understand the related mechanism and design strategies to develop B tolerant cultivars. Graphical Abstract NOVELTY STATEMENT The physio-biochemical and molecular responses and mechanism of B uptake under its toxic condition have been illustrated. The spatial distribution of boron under its toxic condition and its accumulation in the plant might be regulated with sugar alcohols (polyols). This review throws light on the elevated level of B in the soil-plant system and provides management strategies for alleviating B toxicity in the plant.
Steering light in fiber-optic medical devices: a patent review

ABSTRACT Introduction Steering light is relevant to many medical applications that require tissue illumination, sensing, or modification. To control the propagation direction of light beams, a great variety of innovative fiber-optic medical devices have been designed. Areas covered This review provides a comprehensive overview of the patent literature on light beam control in fiber-optic medical devices. The Web of Science Derwent Innovation Index database was scanned, and 81 patents on fiber-optic devices published in the last 20 years (2001–2021) were retrieved and categorized based on the working principle to steer light (refraction/reflection, scattering, diffraction) and the design strategy that was employed (within fiber, at fiber end, outside fiber). Expert opinion Patents describing medical devices were found for all categories, except for generating diffraction at the fiber end surface. The insight in the different designs reveals that there are still several opportunities to design innovative devices that can collect light at an angle off-axis, reduce the angular distribution of light, or split light into multiple beams.
Patient Characteristics Associated With Missed Appointments in Pediatric Subspecialty Clinics

ABSTRACT Objectives: Missed appointments negatively affect patients, providers, and health systems. This study aimed to (1) quantify the percentage of missed appointments across 14 pediatric subspecialties in a tertiary-care children's hospital and (2) identify patient characteristics associated with missed appointments in those subspecialties. Methods: We extracted patient characteristics from 267,151 outpatient appointments, between January 1, 2013, and December 31, 2018, across 14 subspecialty clinics. Medical complexity was categorized using the Pediatric Medical Complexity Algorithm. The primary outcome was appointment nonattendance. Cancellations, imaging/laboratory visits, patients older than 18 years, and duplicate visits were excluded. Characteristics associated with nonattendance were analyzed with chi-square tests and included in the multivariable model if p < . 1. Missing data were addressed using random forest imputation, and assuming data were “missing at random. ” Variables were considered statistically significant if p < . 05. Results: Of the 128,117 scheduled appointments analyzed, 23,204 (18.1%) were missed. In the multivariable model, clinical nutrition had the greatest subspecialty odds of missed appointments, whereas cardiology had the lowest. Patient characteristics most strongly associated with missed appointments were public insurance, history of >2 missed appointments, appointment lead time, lesser medical complexity, Black race/ethnicity, and fewer medications. Conclusions: Clinical characteristics including lesser medical complexity and fewer medications are associated with missed appointments in pediatric subspecialties.
Broadband circularly-polarised chifre-shaped monopole antenna with asymmetric feed

A broadband circularly-polarised monopole antenna is proposed. The broadband property of the antenna is basically achieved not only by the chifre-shaped monopole radiator, but also its asymmetric feed. The circular-polarisation characteristics are greatly enhanced by adjusting the location of the monopole microstrip-feed. The antenna delivers good performance on impedance matching and circular polarisation. The measured results demonstrate that the impedance bandwidth is 72% and the 3-dB axial-ratio bandwidth reaches 41.6% with a central frequency of 2.5 GHz.
Spirituality in Brazilian family caregivers of patients with cancer from the end-of-life care to bereavement

Abstract Although spirituality can be a source of support during end-of-life and engage a transformative experience after loss, few studies report family members’ spiritual and existential needs considering their experiences over time. We conducted a longitudinal interpretative phenomenological analysis from audio-recorded interviews of 10 family caregivers while providing end-of-life care for cancer patients and during bereavement. Participants’ spirituality experiences were presented in three superordinate themes: connectedness with religious beliefs and the deceased; re-signifying relationships, life, and loss; suffering and the family caregiver’s needs. Finding connection through relationships, greater existential and spiritual suffering post-loss were important issues involved in expressing their spirituality.
Indefinitely Renewable Copyright and the Current Copyright System: A Two Country Setting Comparison

As an alternative to the current copyright system (FLC), indefinitely renewable copyright (IRC) has not been compared to the current system in international settings. We compare them in a two country setting. We find that optimally configured IRC does not necessarily lead to higher national or global welfare than an optimally configured FLC.
A bottom-up integration of vision and actions to create cognitive humanoids

In recent years more and more complex humanoid robots have been developed. On the other hand programming these systems has become more difficult. There is a clear need for such robots to be able to adapt and perform certain tasks autonomously, or even learn by themselves how to act. An important issue to tackle is the closing of the sensorimotor loop. Especially when talking about humanoids the tight integration of perception with actions will allow for improved behaviours, embedding adaptation on the lower-level of the system.
RAGE has potential pathogenetic and prognostic value in nonintubated hospitalized patients with COVID-19

Background The value of the soluble receptor for advanced glycation end-products (sRAGE) as a biomarker in COVID-19 is not well understood. We tested the association between plasma sRAGE and illness severity, viral burden, and clinical outcomes in hospitalized patients with COVID-19 who were not mechanically ventilated. Methods Baseline sRAGE was measured among participants enrolled in the ACTIV-3/TICO trial of bamlanivimab for hospitalized patients with COVID-19. Spearman’s rank correlation was used to assess the relationship between sRAGE and other plasma biomarkers, including viral nucleocapsid antigen. Fine-Gray models adjusted for baseline supplemental oxygen requirement, antigen level, positive endogenous anti-nucleocapsid antibody response, sex, age, BMI, diabetes mellitus, renal impairment, corticosteroid treatment, and log2-transformed IL-6 level were used to assess the association between baseline sRAGE and time to sustained recovery. Cox regression adjusted for the same factors was used to assess the association between sRAGE and mortality. Results Among 277 participants, baseline sRAGE was strongly correlated with viral plasma antigen concentration (ρ = 0.57). There was a weaker correlation between sRAGE and biomarkers of systemic inflammation, such as IL-6 (ρ = 0.36) and CRP (ρ = 0.20). Participants with plasma sRAGE in the highest quartile had a significantly lower rate of sustained recovery (adjusted recovery rate ratio, 0.64 [95% CI, 0.43–0.90]) and a higher unadjusted risk of death (HR, 4.70 [95% CI, 2.01–10.99]) compared with participants in the lower quartiles. Conclusion Elevated plasma sRAGE in hospitalized, nonventilated patients with COVID-19 was an indicator of both clinical illness severity and plasma viral load. Plasma sRAGE in the highest quartile was associated with a lower likelihood of sustained recovery and higher unadjusted risk of death. These findings, which we believe to be novel, indicate that plasma sRAGE may be a promising biomarker for COVID-19 prognostication and clinical trial enrichment. Trial Registration ClinicalTrials.gov NCT04501978. Funding NIH (5T32GM008440-24, 18X107CF6, HHSN261201500003I, R35HL140026, and OT2HL156812).
Two new isoflavones from the barks of Dalbergia hancei Benth

Abstract Two new isoflavone compounds, Dalhancei A (1) and Dalhancei B (2), along with a known compound epicatechin (3) were isolated from 80% methanol extract of the barks of Dalbergia hancei Benth. The structures of compounds 1–3 were elucidated by comparison with the literature and physical data analysis, including optical rotation, MS, 1D and 2D NMR spectra. Compounds 1 and 2 showed weak inhibitory activity against tyrosinase at 16.22 mmol/L, with inhibition rates of 42.23 ± 0.18% and 45.68 ± 0.17%, respectively; compound 1 exhibited weak inhibitory activity against α-glucosidase with the inhibition rate of 43.72 ± 0.22% at 5.41 mmol/L, compounds 2 and 3 had better α-glucosidase inhibitory activity than compound 1 with IC50 values of 0.90 ± 0.18 and 0.41 ± 0.17 mmol/L, respectively. Graphical Abstract
The association between skeletal muscle measures and chemotherapy‐induced toxicity in non‐small cell lung cancer patients

Chemotherapy‐induced toxicities frequently occur in non‐small cell lung cancer (NSCLC) patients treated with platinum‐based chemotherapy. Low skeletal muscle mass (SMM) has been associated with a higher incidence of toxicities for several types of cancers and cytostatics. The aim of this study was to evaluate the association between skeletal muscle measures and chemotherapy‐induced toxicity in a large cohort of NSCLC patients.
Moral values and moral identity moderate the indirect relationship between sport supplement use and doping use via sport supplement beliefs

ABSTRACT The Incremental Model of Doping Behaviour suggests doping grows out of the habitual use of performance-enhancing methods (e.g., sport supplements) and belief that they are necessary for performance. Importantly, in this model, doping is viewed as functional rather than moral choice. In two studies, we examined whether sport supplement use was indirectly related to doping use via sport supplement beliefs, and whether personal morality moderated this relationship. Competitive athletes (Study 1, N = 366; Study 2, N = 200) completed measures of supplement use, beliefs, and doping use. They also completed measures of moral values (Study 1) and moral identity (Study 2). In both studies, supplement use was indirectly related to doping use via beliefs. Moreover, this indirect relationship was moderated by moral values (Study 1) and moral identity (Study 2). That is, the relationship between supplement use and doping use via beliefs was negated when moral values and moral identity were high but not when they were low or moderate. Taken together, our findings suggest that sport supplement users, who believe they are necessary, are more likely to dope if they have low moral values and believe that being a moral person is unimportant to their self-image.
14-3-3ζ Constrains insulin secretion by regulating mitochondrial function in pancreatic β cells

While critical for neurotransmitter synthesis in the brain, members of the 14-3-3 protein family are often assumed to have redundant, over-lapping roles due to their high sequence homology and ubiquitous expression. Despite this assumption, various mammalian 14-3-3 isoforms have now been implicated in regulating cellular and organismal metabolism; however, these functions were primarily observed in cell lines or from systemic knockout mouse models. To date, we have begun to define the contributions of 14-3-3ζ in adipocytes, but whether 14-3-3ζ has additional metabolic roles in other cell types, such as the pancreatic β-cell, is unclear. We previously documented a pro-survival role of 14-3-3ζ in MIN6 insulinoma cells, as depletion of 14-3-3ζ induced cell death, but paradoxically, whole-body deletion of 14-3-3ζ in mice resulted in significantly enlarged β-cell area with no effects on insulin secretion. To better understand the role of 14-3-3ζ in β-cells, we generated β-cell-specific 14-3-3ζ knockout (β14-3-3ζKO) mice, and while no differences in β-cell mass were observed, β14-3-3ζKO mice displayed potentiated insulin secretion due to enhanced mitochondrial function and ATP synthesis. Deletion of 14-3-3ζ led to profound changes to the β-cell transcriptome, where pathways associated with mitochondrial respiration and oxidative phosphorylation were upregulated. Acute treatment of mouse islets and human islets with pan-14-3-3 inhibitors recapitulated the potentiation in glucose-stimulated insulin secretion (GSIS) and mitochondrial function, suggesting that 14-3-3ζ is a critical isoform in β-cells that regulates GSIS. In dysfunctional db/db islets and islets from type 2 diabetic donors, expression of Ywhaz/YWHAZ, the gene encoding 14-3-3ζ, was inversely associated with insulin secretory capacity, and pan-14-3-3 protein inhibition was capable of enhancing GSIS and mitochondrial function. Taken together, this study demonstrates important regulatory functions of 14-3-3ζ and its related isoforms in insulin secretion and mitochondrial function in β-cells. A deeper understanding of how 14-3-3ζ influences β-cell function will further advance our knowledge of how insulin secretion from β-cells is regulated.
Unsupervised Feature Selection via Graph Regularized Nonnegative CP Decomposition

Unsupervised feature selection has attracted remarkable attention recently. With the development of data acquisition technology, multi-dimensional tensor data has been appeared in enormous real-world applications. However, most existing unsupervised feature selection methods are non-tensor-based which results the vectorization of tensor data as a preprocessing step. This seemingly ordinary operation has led to an unnecessary loss of the multi-dimensional structural information and eventually restricted the quality of the selected features. To overcome the limitation, in this paper, we propose a novel unsupervised feature selection model: Nonnegative tensor CP (CANDECOMP/PARAFAC) decomposition based unsupervised feature selection, CPUFS for short. In specific, we devise new tensor-oriented linear classifier and feature selection matrix for CPUFS. In addition, CPUFS simultaneously conducts graph regularized nonnegative CP decomposition and newly-designed tensor-oriented pseudo label regression and feature selection to fully preserve the multi-dimensional data structure. To solve the CPUFS model, we propose an efficient iterative optimization algorithm with theoretically guaranteed convergence, whose computational complexity scales linearly in the number of features. A variation of the CPUFS model by incorporating nonnegativity into the linear classifier, namely CPUFSnn, is also proposed and studied. Experimental results on ten real-world benchmark datasets demonstrate the effectiveness of both CPUFS and CPUFSnn over the state-of-the-arts.