Miracle-dz/UniFAR-FTUs huggingface dataset:
Ergotamine Abuse: Results of Ergotamine Discontinuation, With Special Reference To the Plasma Concentrations

Twenty-three patients suffering from continuous headache linked with habitual daily use of ergotamine tartrate were studied. Their headaches were classified clinically, and possible side effects of ergotamine medication, plasma levels of ergotamine, and occurrence of withdrawal symptoms after discontinuation of drug abuse were recorded. Seventeen of the patients were clinically diagnosed as suffering from “ergotamine headache”, and seven of them complained of coldness in the extremities. Plasma ergotamine levels were measured by using a radioimmunoassay. In almost half of the patients the 1 h plasma levels after the daily dose were below the detection limit of the procedure (0.12 ng/ml). The duration and severity of the withdrawal symptoms did not correlate with the doses and plasma levels of ergotamine. In only 4 of the 21 patients who were followed up for 3 to 6 months did headache symptoms not improve after ergotamine withdrawal. The results indicate that even small (0.5-1.0 mg/day) doses of ergotamine tartrate taken regularly may cause continuous headache symptoms and withdrawal symptoms after discontinuation.
A COMPREHENSIVE AND PROSPECTIVE ANALYSIS TO IMPROVE PATIENT OUTCOMES IN POSTOPERATIVE PERIOD BY OPTIMIZING NEOSTIGMINE DOSE AND TIMING WITH THE HELP OF TOF MONITORING

Objective: The objective is to find out the optimum neuromuscular reversal strategy using Train-of-Four (TOF) monitoring in the postoperative period for complete and risk-free recovery without residual paralysis. In this study, the neuromuscular blockade brought on by cisatracurium will be reversed using a neuromuscular monitor (TOF) and neostigmine administered at the best possible time and dose. In addition, we'll look at the prevalence of neuromuscular paralysis that persists after general anesthesia, as some research have revealed that paralysis may worsen and return once patients leave the recovery area. Methods: A comprehensive prospective, randomized, double-blind and prospective analysis was conducted involving various study groups. Demographic data, residual neuromuscular weakness, negative head lift tests, and Visual Analog Scale (VAS) scores were assessed. TOF monitoring was used regularly to tailor neuromuscular reversal strategies. Results: Incidence of regression of TOF ratio<0.9 and incidence of negative head lift test after extubation among different groups were statistically non-significant by Chi square test at 15 min (p value 0.4), 30 min (0.8) and 60 min (p value 0.9). It also concludes that neuromuscular stimulation given for TOF monitoring is well tolerated by different group of the population in terms of VAS score (mean 3.9, ranging from 3.3 to 3.8). Conclusion: This research suggests that tailoring strategies of neostigmine dose and time of its administration according to TOF ratio leads to complete recovery of neuromuscular function with all the doses (20/30/40 micrograms/kg). This study emphasizes the use of neuromuscular monitoring guided reversal methods to attain complete recovery without residual paralysis.
Genome-wide association studies for phenological and agronomic traits in mungbean (Vigna radiata L. Wilczek)

Mungbean (Vigna radiata L. Wilczek) is one of the important warm-season food legumes, contributing substantially to nutritional security and environmental sustainability. The genetic complexity of yield-associated agronomic traits in mungbean is not well understood. To dissect the genetic basis of phenological and agronomic traits, we evaluated 153 diverse mungbean genotypes for two phenological (days to heading and days to maturity) and eight agronomic traits (leaf nitrogen status using SPAD, plant height, number of primary branches, pod length, number of pods per plant, seeds per pod, 100-seed weight, and yield per plant) under two environmental conditions. A wide array of phenotypic variability was apparent among the studied genotypes for all the studied traits. The broad sense of heritability of traits ranged from 0.31 to 0.95 and 0.21 to 0.94 at the Delhi and Ludhiana locations, respectively. A total of 55,634 genome-wide single nucleotide polymorphisms (SNPs) were obtained by the genotyping-by-sequencing method, of which 15,926 SNPs were retained for genome-wide association studies (GWAS). GWAS with Bayesian information and linkage-disequilibrium iteratively nested keyway (BLINK) model identified 50 SNPs significantly associated with phenological and agronomic traits. In total, 12 SNPs were found to be significantly associated with phenological traits across environments, explaining 7%–18.5% of phenotypic variability, and 38 SNPs were significantly associated with agronomic traits, explaining 4.7%–27.6% of the phenotypic variability. The maximum number of SNPs (15) were located on chromosome 1, followed by seven SNPs each on chromosomes 2 and 8. The BLAST search identified 19 putative candidate genes that were involved in light signaling, nitrogen responses, phosphorus (P) transport and remobilization, photosynthesis, respiration, metabolic pathways, and regulating growth and development. Digital expression analysis of 19 genes revealed significantly higher expression of 12 genes, viz. VRADI01G08170, VRADI11G09170, VRADI02G00450, VRADI01G00700, VRADI07G14240, VRADI03G06030, VRADI02G14230, VRADI08G01540, VRADI09G02590, VRADI08G00110, VRADI02G14240, and VRADI02G00430 in the roots, cotyledons, seeds, leaves, shoot apical meristems, and flowers. The identified SNPs and putative candidate genes provide valuable genetic information for fostering genomic studies and marker-assisted breeding programs that improve yield and agronomic traits in mungbean.
Constant-Time Machine Translation with Conditional Masked Language Models

Most machine translation systems generate text autoregressively, by sequentially predicting tokens from left to right. We, instead, use a masked language modeling objective to train a model to predict any subset of the target words, conditioned on both the input text and a partially masked target translation. This approach allows for efficient iterative decoding, where we first predict all of the target words non-autoregressively, and then repeatedly mask out and regenerate the subset of words that the model is least confident about. By applying this strategy for a constant number of iterations, our model improves stateof-the-art performance levels for constant-time translation models by over 3 BLEU on average. It is also able to reach 92-95% of the performance of a typical left-to-right transformer model, while decoding significantly faster.
Enhancing the Photocatalytic Activity by Tailoring an Anodic Aluminum Oxide Photonic Crystal to the Semiconductor Catalyst: At the Example of Iron Oxide

Photonic crystals (PhCs) are interesting structures for photocatalytic applications because of their capability of harnessing distinct forms of light–matter interactions within the PhCs. Of all these, overlapping one of the photonic stopband's (PSB) edge with the absorption of the PhC material or adsorbed molecules improves their excitation and generated charge carriers can subsequently induce photocatalytic reactions. The PSB position of anodic aluminum oxide PhCs (AAO‐PhCs) can be easily adjusted by modifying the anodization profile. Herein, AAO‐PhCs are designed to match the band gap of a model semiconductor enabling a general photocatalytic activity enhancement independent of the chemical to be decomposed. Fe2O3, as an example photocatalyst, is coated onto AAO‐PhCs to demonstrate efficient photocatalytic systems by utilizing the slow photon effect. Tailored Fe2O3‐AAO‐PhCs with their PSB edge at 564 nm matching the Fe2O3 band gap exhibit generally enhanced degradation of three different organic dyes while a significant activity decrease is observed when the PSB edge does not overlap with the Fe2O3 absorption. Furthermore, photocatalyst degradation can be reduced down to only 4% activity loss over six consecutive measurements by an ultra‐thin alumina coating.
Maximum Torque to Current control of a Synchronous Reluctance Machine by including cross-magnetisation.

This paper investigates the effect of cross-magnetisation on Maximum Torque to Current control of a Synchronous Reluctance Machine. A new model of the machine based on Park's equations and including saturation effects is first developed. From this saturated model, a new maximum torque to current condition is obtained. Several experimental results are then presented to verify the accuracy of the theoretical analysis.
Thermosensitive Hydrogel-Functionalized Mesoporous Silica Nanoparticles for Parenteral Application of Chemotherapeutics

Hydrogels can offer many opportunities for drug delivery strategies. They can be used on their own, or their benefits can be further exploited in combination with other nanocarriers. Intelligent hydrogels that react to changes in the surrounding environment can be utilized as gatekeepers and provide sustained on-demand drug release. In this study, a hybrid nanosystem for temperature- and pH-sensitive delivery was prepared from MCM-41 nanoparticles grafted with a newly synthesized thermosensitive hydrogel (MCM-41/AA-g-PnVCL). The initial particles were chemically modified by the attachment of carboxyl groups. Later, they were grafted with agar (AA) and vinylcaprolactam (VCL) by free radical polymerization. Doxorubicin was applied as a model hydrophilic chemotherapeutic drug. The successful formulation was confirmed by FT-IR and TGA. Transmission electron microscopy and dynamic light scattering analysis showed small particles with negative zeta potential. Their release behaviour was investigated in vitro in media with different pH and at different temperatures. Under tumour simulating conditions (40 °C and pH 4.0), doxorubicin was almost completely released within 72 h. The biocompatibility of the proposed nanoparticles was demonstrated by in vitro haemolysis assay. These results suggest the possible parenteral application of the newly prepared hydrogel-functionalized mesoporous silica nanoparticles for temperature-sensitive and pH-triggered drug delivery at the tumour site.
A revised model for activity–composition relations in solid and molten FePt alloys and a preliminary model for characterization of oxygen fugacity in high-pressure experiments

Abstract. We present new models for the activity of iron (γFe) in solid face-centered cubic (fcc) and liquid FePt alloy at high temperature and pressure to facilitate their use as sliding buffer redox sensors under extreme conditions. Numerous experimental studies of γFe in FePt alloy at 100 kPa have produced a wide spread of values. By favoring high-temperature studies that are more likely to have produced equilibrium measurement and excluding experiments for compositions and temperatures that probably encountered ordered or unmixed low-temperature phases, we regress an asymmetric Margules activity–composition model with parameters WFePtfcc=-121.5±2.1 kJ mol−1 and WPtFefcc=-93.3±4.3 kJ mol−1. These values are close to the widely used model of Kessel et al. (2001), but for Pt-rich compositions they predict larger Fe activities and correspondingly more reduced oxygen fugacities. Activity–composition relations in liquid FePt are calibrated from direct measurements of activities and, most sensitively, from the trace of the Fe–Pt liquidus. Together, these yield asymmetric Margules parameters of WFePtliq=-124.5 kJ mol−1 and WPtFeliq=-94.0 kJ mol−1. The effects of pressure on both fcc and liquid FePt alloy are considered from excess-volume relations. Both solid and liquid alloy display significant positive excess volumes of mixing. Extraction of the excess volume of mixing for fcc FePt alloy requires filtering data for ordered low-temperature phases and corrections for the effects of magnetostriction on Fe-rich compositions which exhibit “Invar” behavior. Applied at high temperatures and pressures, both solid and liquid FePt alloys have strongly negative deviations from ideality at low pressure, which become closer to ideal at high pressure. These models provide a provisional basis for the calculation of aFe in high-temperature, high-pressure experiments that, when combined with estimates of aFeO, allow characterization of fO2 under conditions relevant to magma oceans, core formation, and differentiation processes in the lower mantle of Earth or on other terrestrial planets. Improvements in these models require new constraints on the equation of state of FePt fcc alloy and documentation of the high-pressure melting relations in the system Fe–Pt.
Risk factors of gastrointestinal bleeding after cardiopulmonary bypass in children: a retrospective study

Background During cardiac surgery that involved cardiopulmonary bypass (CPB) procedure, gastrointestinal (GI) system was known to be vulnerable to complications such as GI bleeding. Our study aimed to determine the incidence and risk factors associated with GI bleeding in children who received CPB as part of cardiac surgery. Methods This retrospective study enrolled patients aged <18 years who underwent cardiac surgery with CPB from 2013 to 2019 at Shanghai Children's Medical Center. The primary outcome was the incidence of postoperative GI bleeding in children, and the associated risk factors with postoperative GI bleeding episodes were evaluated. Results A total of 21,893 children who underwent cardiac surgery with CPB from 2013 to 2019 were included in this study. For age distribution, 636 (2.9%) were neonates, 10,984 (50.2%) were infants, and 10,273 (46.9%) were children. Among the 410 (1.9%) patients with GI bleeding, 345 (84.2%) survived to hospital discharge. Incidence of GI bleeding in neonates, infants and children were 22.6% (144/636), 2.0% (217/10,984) and 0.5% (49/10,273), respectively. The neonates (22.6%) group was associated with highest risk of GI bleeding. Patients with GI bleeding showed longer length of hospital stays (25.8 ± 15.9 vs. 12.5 ± 8.9, P < 0.001) and higher mortality (15.9% vs. 1.8%, P < 0.001). Multivariate logistic regression analysis showed that age, weight, complicated surgery, operation time, use of extracorporeal membrane oxygenation (ECMO), low cardiac output syndrome (LCOS), hepatic injury, artery lactate level, and postoperative platelet counts were significantly associated with increased risk of GI bleeding in children with congenital heart disease (CHD) pediatric patients that underwent CPB procedure during cardiac surgery. Conclusion The study results suggest that young age, low weight, long operation time, complicated surgery, use of ECMO, LCOS, hepatic injury, high arterial lactate level, and low postoperative platelet counts are independently associated with GI bleeding after CPB in children.
Efficacy of the combination of valsartan and hydrochlorothiazide in the treatment of hypertensive heart disease

Purpose: To investigate the effectiveness of the combination of valsartan and hydrochlorothiazide in managing hypertensive heart disease.Methods: From August 2020 to October 2022, the case data of 120 patients in Lu’an Hospital of Anhui Medical University, Lu’an, China were analyzed retrospectively. Based on the different treatment options, 54 patients with hypertensive heart disease who received valsartan alone (80 mg, once daily) for 3 months were placed in control group (CG), while 66 patients who received valsartan combined with Systolic blood pressure (SBP), therapeutic effect, diastolic blood pressure (DBP), and incidence of adverse effects were also recorded for CG and SG.Results: In the SG, there were significant reductions in SBP, DBP, LVMI and LVPWT compared to CG, while EF showed significant increase after treatment (p < 0.05). In both groups, SBP, DBP, LVMI and LVPWT decreased significantly after treatment compared to pre-treatment values, but EF however showed a significant increase (p < 0.05). In the SG, there was a significant increase (p < 0.05) in the total effective rate compared to CG and there was also a significant reduction (p < 0.05) in the total incidence of adverse effects compared to CG.Conclusion: Valsartan combined with hydrochlorothiazide is more effective in treating patients with hypertensive heart disease than valsartan monotherapy alone. However, the combination treatment should be subjected to further clinical trials prior to its introduction into clinical practice.
CULTURE-DEPENDENT APPROACHES AMONG THE CARIES PATHOGENS ISOLATED FROM THE CARIOUS DENTINE AND THEIR EMERGING DRUG RESISTANCE

Objective: To evaluate the commonest caries pathogens from different type of caries andto screen for the emergence of drug resistance among the caries causing pathogenic bacteria. Methods: A cross-sectional study was conducted in the department of Microbiology. Sample Size was 44 and samples from carious dentine which was immediately transported to the microbiology laboratory. Samples were processed microbiologically to isolate the caries pathogens. Identification of strains were done by standard biochemical characterization studies. The isolates were subjected to antimicrobial sensitivity test. The results were recorded and analyzed for drug resistance. Results: Out of 44 patients, 40 aerobic bacteria, 2 anaerobic bacteria and 2 fungi were isolated. Out of the 40 aerobic bacteria, the most common isolated was Klebsiella pneumoniae followed by Pseudomonas spp. and Streptococcus viridians. Ciprofloxacin, Gentamycin and Linezolid showed excellent activity against Gram-positive Bacteria. The most frequently involved teeth of dental caries were mandibular 1st molar (54.54%) followed by Mandibular 2nd molar (13.63%). Conclusion: In our study we found that Klebsiella pneumoniae, Pseudomonas sp. , Streptococcus viridians were the most frequent organisms encountered. The study implicates the need for time to time antimicrobial susceptibility examination of the dental caries pathogens that will help to prevent the emergence of resistance property among the dentinal pathogenic organisms.
Urinary exosomes: a promising biomarker of drug-induced nephrotoxicity

Drug-induced nephrotoxicity (DIN) is a big concern for clinical medication, but the clinical use of certain nephrotoxic drugs is still inevitable. Current testing methods make it hard to detect early renal injury accurately. In addition to understanding the pathogenesis and risk factors of drug-induced nephrotoxicity, it is crucial to identify specific renal injury biomarkers for early detection of DIN. Urine is an ideal sample source for biomarkers related to kidney disease, and urinary exosomes have great potential as biomarkers for predicting DIN, which has attracted the attention of many scholars. In the present paper, we will first introduce the mechanism of DIN and the biogenesis of urinary exosomes. Finally, we will discuss the changes in urinary exosomes in DIN and compare them with other predictive indicators to enrich and boost the development of biomarkers of DIN.
Comparison of CD4+/CD8+ Lymphocytic Subpopulations Pre- and Post-Antituberculosis Treatment in Patients with Diabetes and Tuberculosis

Is there a CD4+ and CD8+ immunity alteration in patients with pulmonary tuberculosis (TB) and diabetes (DM) that does not recover after antituberculosis treatment? This prospective comparative study evaluated CD4+ and CD8+ lymphocytic subpopulations and antituberculosis antibodies in patients with diabetes and tuberculosis (TB-DM), before and after antituberculosis treatment. CD4+ T cell counts were lower in patients with TB-DM compared to those with only TB or only DM, and these levels remained low even after two months of anti-TB treatment. Regarding the CD8+ T cell analysis, we identified higher blood values in the DM-only group, which may be explained by the high prevalence of latent tuberculosis (LTBI) in patients with DM. IgM antituberculosis antibodies levels were elevated in patients with only TB at baseline, and 2 months post-anti-TB treatment, IgG did not express any relevant alterations. Our results suggest an alteration in CD4+ immunity in patients with TB-DM that did not normalize after antituberculosis treatment.
Cultural Planning : An Urban Renaissance?

1: Introduction 2: The Historical Evolution of City Arts and Cultural Planning 3: Urban Culture and the early Industrial City 4: Amenity Planning and the Arts Centre 5: Models and Standards of Arts Provision 6: The Cultural Economy - from Arts Amenity to Culture Industry 7: European Common Culture and Planning for Regional Development 8: Cities of Culture and the Urban Renaissance 9: Planning for the Arts: An Urban Renaissance?
Anti-Cancer Potential of Transiently Transfected HER2-Specific Human Mixed CAR-T and NK Cell Populations in Experimental Models: Initial Studies on Fucosylated Chondroitin Sulfate Usage for Safer Treatment

Human epidermal growth factor receptor 2 (HER2) is overexpressed in numerous cancer cell types. Therapeutic antibodies and chimeric antigen receptors (CARs) against HER2 were developed to treat human tumors. The major limitation of anti-HER2 CAR-T lymphocyte therapy is attributable to the low HER2 expression in a wide range of normal tissues. Thus, side effects are caused by CAR lymphocyte “on-target off-tumor” reactions. We aimed to develop safer HER2-targeting CAR-based therapy. CAR constructs against HER2 tumor-associated antigen (TAA) for transient expression were delivered into target T and natural killer (NK) cells by an effective and safe non-viral transfection method via nucleofection, excluding the risk of mutations associated with viral transduction. Different in vitro end-point and real-time assays of the CAR lymphocyte antitumor cytotoxicity and in vivo human HER2-positive tumor xenograft mice model proved potent cytotoxic activity of the generated CAR-T-NK cells. Our data suggest transient expression of anti-HER2 CARs in plasmid vectors by human lymphocytes as a safer treatment for HER2-positive human cancers. We also conducted preliminary investigations to elucidate if fucosylated chondroitin sulfate may be used as a possible agent to decrease excessive cytokine production without negative impact on the CAR lymphocyte antitumor effect.
Disaat Fotografi Jurnalistik Bukan Sekedar Pemberitaan

Dewasa ini banyak foto yang ditampilkan oleh media sebagai foto pemberitaan. Namun bila ditelaah lebih jauh, bidang fotografi mempunyai berbagai jenis dan macamnya, diantaranya adalah bidang fotografi jurnalistik dan fotografi human interest. Tulisan ini mengangkat tentang cara memahami perbedaan antara fotografi jurnalistik dan human interest yang kemudian memunculkan sebuah konsep baru dalam dunia fotografi. Penulis memcoba membongkar kebiasaan fotografer jurnalistik yang sampai saat ini masih banyak yang memenggunakan fotografi human interest dalam pemberitaan. Fotografi merupakan pesan non verbal, yang berarti tak menggunakan kata-kata namun memberikan sebuah gambar dengan makna yang tersirat di dalamnya. Fotografi human interest merupakan foto seseorang (banyak orang) yang sedang melakukan suatu hal, ada sebuah interaksi antara objek dan apa yang dilakukannya. Fotografi jurnalistik dan human interest mempunyai batasan-batasan sehingga hasil foto yang dihasilkan mempunyai karakter tersendiri.