Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of non-coding RNA (Ribonucleic acid) in the LC-Lung Cancer pathogenesis system

: Lung Cancer is a globally alarming deathly disease; the present circumstance is additionally upheld by yearly expansion in new (Lung Cancer) LC-cases and its helpless five years endurance which is under 15%. Albeit an enormous level of LC, cases have been credited to smoking, a lot of non-smokers likewise fosters this sickness, accordingly recommending a hereditary as well as an epigenetic hint to LC advancement. A few developments related to qualities like epidermal development factor receptor (EGFR) and vascular endothelial development factor (VEGF) just as growth silencer qualities, for example, p53 have been involved in LC pathogenesis and movement. Similarly, the genome just holds back around 1% of coding areas. Henceforth, noncoding part of the genome, for example, noncoding RNAs (ncRNAs) has been considered and found to assume a fitting part in LC pathogenesis. All the more exactly, microRNAs (miRNAs) and long ncRNAs (lncRNAs) have been read for quite a long time. The posttranscriptional quality balance capacity of miRNAs is grounded and described. Moreover, the offending communication among lncRNAs and miRNAs had additionally been demonstrated to additional control quality articulation during solid and infection conditions like LC. All the more as of late, restored consideration toward roundabout RNAs circular RNAs (circRNAs) study showed that circRNAs can likewise wipe miRNAs to regulate quality articulations as well. Henceforth, miRNAs, lncRNAs, and circRNAs appear to work inside a circuit to ideally figure out which quality is should have been upregulated or on the other hand downregulated in the organic framework. Consequently, this survey will talk about significant ncRNAs, in particular miRNA, lncRNA, and circRNA in LC movement. more, the possibility of these ncRNAs in better LC treatment will be featured also.
Cell Cycle-dependent Initiation of Hepatocarcinogenesis in Rats by (Â±)-7r,8f-Dihydroxy-9f,

Male F344 rats were treated once with (Â±)-7r,8r-dihydroxy-9f,10f- epoxy-7,8,9,10-tetrahydrobenzo(a)p)Tene (BPDE) at various times after a two-thirds partial hepatectomy. Diet containing 0.05% phÃ©nobarbital was fed subsequently to promote the development of hepatocellular neoplasms from initiated cells. This combined treatment caused an ap parently continuous emergence of hepatocellular neoplasms between 31 and 60 weeks after initiation. Yields of hepatocellular neoplasms (ade nomas and carcinomas) seen at 45 weeks after initiation varied according to the time of treatment with BPDE. Rats treated at 15 h after partial hepatectomy, when maximal fractions of proliferating hepatocytes were entering the S phase, displayed the greatest incidence and yield of hepatocellular neoplasms. Rats treated when hepatocytes were early in the prereplicative <. , phase demonstrated a significantly lower incidence and yield of hepatocellular neoplasms. No neoplasms were seen in livers of rats treated with BPDE without prior partial hepatectomy; this indi cates the insensitivity or resistance of nonproliferating Gohepatocytes to initiation by this chemical. The variation in yields of neoplasms could not be attributed to variation in binding of carcinogen to DNA or to rates of DNA repair. The risk of initiation of hepatocytes appeared to be corre lated (r = 0.95) with the fraction of hepatocytes that were entering the S phase at the time of treatment with BPDE. These results reveal a significant cell cycle dependency for initiation of hepatocarcinogenesis by BPDE and show that proliferating hepatocytes are at greatest risk when early in the S phase. Quantitation of islands of hepatocellular alteration suggested a similar pattern of cell cycle-dependent sensitivity, although the cycle-dependent variation in island frequencies (1.4-fold) was less than the variation in yields of neoplasms (5-fold). However, 1300-5000 islands were estimated to appear for every one neoplasm that appeared. When viewed within the context of multistep carcinogenesis, and assum ing that islands of altered hepatocytes represent a step in this process, then these results suggest that islands may represent populations of cells at least one step removed from neoplasia.
Edinburgh Research Explorer The serine-rich N-terminal domain of oat phytochrome a helps regulate light responses and subnuclear localization of the photoreceptor

Phytochrome (phy) A mediates two distinct photobiological responses in plants: the very-low-fluence response (VLFR), which can be saturated by short pulses of very-low-fluence light, and the high-irradiance response (HIR), which requires prolonged irradiation with higher fluences of far-red light (FR). To investigate whether the VLFR and HIR involve different domains within the phyA molecule, transgenic tobacco ( Nicotiana tabacum cv Xanthi) and Arabidopsis seedlings expressing full-length (FL) and various deletion mutants of oat ( Avena sativa ) phyA were examined for their light sensitivity. Although most mutants were either partially active or inactive, a strong differential effect was observed for the (cid:1) 6-12 phyA mutant missing the serine-rich domain between amino acids 6 and 12. (cid:1) 6-12 phyA was as active as FL phyA for the VLFR of hypocotyl growth and cotyledon unfolding in Arabidopsis, and was hyperactive in the VLFR of hypocotyl growth and cotyledon unfolding in tobacco, and the VLFR blocking subsequent greening under white light in Arabidopsis. In contrast, (cid:1) 6-12 phyA showed a dominant-negative suppression of HIR in both species. In hypocotyl cells of Arabidopsis irradiated with FR phyA:green fluorescent protein (GFP) and (cid:1) 6-12 phyA:GFP fusions localized to the nucleus and coalesced into foci. The proportion of nuclei with abundant foci was enhanced by continuous compared with hourly FR provided at equal total fluence in FL phyA:GFP, and by (cid:1) 6-12 phyA mutation under hourly FR. We propose that the N-terminal serine-rich domain of phyA is involved in channeling downstream signaling via the VLFR or HIR pathways in different cellular contexts.
Chemically deﬁned media and the culture of mammalian preimplantation embryos: historical perspective and current issues

Considerable advances in media development for the culture of preimplantation mammalian embryos have been made since mouse embryos were ﬁrst cultured and successfully transferred to foster mothers. The purpose of this review is to detail the history of the development of chemically deﬁned media for the culture of preimplantation embryos. Two approaches have been used to determine the composition of chemically deﬁned media: the ‘back-to-nature’ approach and ‘let the embryo choose’ or empirical optimization approach. Recent developments, including the supplementation of media with amino acids and the use of sequential media for the extended culture of preimplantation embryos, are critically assessed. Importantly, it is recognized that even the best media currently used are not optimal and inevitably cause imbalances and stress to the embryos. Consequently, preimplantation embryos must adapt to the culture environment in order to survive. The adaptations to stress that occur when embryos are placed in a chemically deﬁned environment are reviewed. The implications of these various stresses on the patterns of gene expression in the early embryo and their potential long-term effects are also emphasized. The scientiﬁc and ethical issues raised by the commercialization of human embryo culture media are brieﬂy addressed.
A RANDOMISED CONTROL STUDY ON THE THERAPEUTIC EFFICACY OF COMBINATION THERAPY OF L-METHYL FOLATE AND ESCITALOPRAM IN DEPRESSION

: Objective: The assessment and evaluation of L-Methyl folate efficacy in the combine form along with the escitalopram in comparison to the escitalopram monotherapy in the depression. Material and Methods: The duration of this study was from January, 2020 to June, 2020 in 6 months at Services Hospital Lahore. The number of patients was 260 which were having Major Depression’s primary diagnosis along with score above fourteen on depression (Hamilton rating scale) i.e., HAM-D & they were selected in this study of Randomized Controlled Trial. The patients were classified in two groups & then group-A was given ten milligram (Escitalopram) in addition to placebo while group B was given ten milligram (Escitalopram) in addition to L-Methyl folate in the form of a dose of 15 mg. Group-A and Group-B were assessed again after 1 month & the scores of HAM-D were measured. Results: In the total number of 260 patients, the response was there in 70.8% i.e., 184 & 29.2% i.e., 76 never responded to the treatment. The patients were 82 at 63.1% which have shown response to treatment but 48 patients at 36.9 % never responded and these patients were total 130 which were treated along with SSRI. In total 130 patients which were treated with escitalopram & L-Methyl folate, 28 at 21.5% never responded and 102 at 78.5% showed response to treatment. With a confidence interval of 95%, the P-value was observed as (0.006) which showed that primary difference of both interventions was statistically significant. Conclusion: In the findings of this study a combination of L-Methyl folate & SSRI in depression may prove to be more efficient as compared to the Escitalopram monotherapy.
A Wide Load Current and Voltage Range Switched Capacitor DC–DC Converter with Load Dependent Configurability for Dynamic Voltage Implementation in Miniature Sensors

Advancements in low power circuits and batteries have enabled the design of miniature sensors with tiny batteries. In such systems, implementing dynamic voltage scaling (DVS) is crucial for maximizing system lifetime. In this paper, a new switched capacitor (SC) converter that is capable of handling a wide range of load currents and output voltages is presented for on-chip DVS implementation. The proposed converter consists of multi-ratio multi-leaf SC stages and reconfigurable interconnect, enabling fine voltage resolution. The stage interconnect scheme enables cascaded or parallel connection of stages. The multi-leaf structure allows load-dependent switch size selection, offering a better trade-off between losses over a wide load range. A limited-voltage-swing switch-driving scheme allows efficient down-conversion from high battery voltage input. A prototype was fabricated in a 180 nm process, providing an output voltage with effective resolution of 16 mV over a load current range of 300 nA to 300 μA (1000×) from a 4 V battery. Efficiency greater than 62% and a peak efficiency of 77% are achieved under a light load (500 nA) over a voltage range of 400 mV to 1.6 V. Efficiency greater than 64% and a peak efficiency of 72% are achieved under a heavy load (200 μA) over a voltage range of 700 mV to 1.6 V.
Simple Zero-Knowledge Proof of Knowing √ X 1 or √ X 2 mod N

Tompa and Woll constructed a zero-knowledge proof of knowing a square root of X mod N , where N is the product of two large, secret primes. In this paper, we construct a zero-knowledge proof of knowing a square root of X 1 or X 2 mod N . Compared with the existing solution to this problem, ours is signiﬁcantly simpler.
Kansei Design Approach Based on Tangible Interaction Explicit Images of 3D Objects and Evaluation of Various Behaviors Related With Creation/Imagination by Analysis of Brain Waves

This study aims to provide an understanding of the Kansei evaluation model in human sciences and its practical use of design interaction. Kansei means subjective criteria work on the emotional aspects of events (Lee, 2000). In a previous study (Lee, 2001), we found several effects of Kansei for evaluation when people appreciate or create paintings or products. This paper describes how Kansei works on design approaches and the relationship it has with personality through brain waves. And finally shows some examples of practical Kansei design approach by tangible interaction. Kansei works differently by people, events, and environments and it brings pure imagination of unconsciousness. Through unconscious evaluation on products, such as sketches and sculpted models, it could be possible to see how he/she feels purely with the product. It introduces experiments on brain waves when people engage in various behaviors. This idea originated in the human sciences has recently been extended to interdisciplinary fields including the medical and neural sciences. We discuss some results that we obtained for concentration using brain waves and how the personality influences creation and various behaviors and creation/imagination. From the correlation between creation/imagination and various behaviors through brain waves we show the possibility of developing an educational support tool for creativity. In this experiment, the data were analyzed by taking into account each subject’s personality and high frequency brain waves. Subjects who were in the N-(stable) area, tended to relax easily in new circumstances and could easily concentrate on the task. The results indicate that, in supporting creativity, tactile experience is useful in increasing neural reactions. Creation may arise from a situation involving concentration with a little tension within a relaxed setting doing tactile behavior. In the end of this paper, design works of tangible interaction is introduced as a trial of practical Kansei design approach. Future studies on the correlation between creativity and personality monitored through brain waves, needs detailed tasks with professional, design-experienced subjects. At the same time, the results of models and sketches are going to be digitized as three dimensional data to be used on the interactive visualization system.
Enhanced Emotional and Speed Deviation Control of Synchronous Reluctance Motor Drives

This paper proposes an enhanced brain emotional learning-based intelligent controller for synchronous reluctance motor (SynRM) drives. The controller is based on an emotional learning and decision making mechanism in the brain via emotional cues and sensory inputs. Furthermore, the enhanced controller improves learning process in the amygdala to avoid internal instability. In spite of the development for interior-stability, the proposed controller could keep its ability to deal with challenges related to SynRM drives. The proposed controller is also contributed with a speed deviation control. The new deviation controller is based on model but parameter-free. The updated system is implemented in real-time by a PC-based three-phase 370 W laboratory SynRM. The proportional-integral (PI) controllers used in a standard rotor field-oriented control structure are replaced with those of the proposed method. The speed and d-axis stator current references are accurately tracked. The achieved performances by the proposed controllers are compared with those of optimized conventional PI controller in different situations. Considering the results, the enhanced system shows superiority over the traditional system in terms of fast dynamics, easy tuning, and robustness against disturbances and parameter variations.
Antitumor Effects of Propolis Against PC3 Prostate Cancer Cells

The incidence of prostate cancer and its mortality rates are remarkably different in diverse geographic regions and among various racial/ethnic populations, with by far the highest rate in North America and the lowest in Asia (Quinn and Babb, 2002). The incidence of clinical prostate cancer in Arabs is among the lowest in the world. Indeed, this ratio is gradually increasing in the Arab world, particularly in Egypt due to many etiological factors including smoking, intake of high-caloric food, inflammation, aging and the improvement of diagnosis and cancer registration methods (Salim et al., 2011). Clinical trials of adjuvant and neoadjuvant chemotherapies for prostate cancer are recently testing new treatments, and new combinations of treatment. It is of great interest to change cancer therapy from chemotherapy to biotherapy, using biological agents with minimal or no adverse side effects. Many plants and animal extracts have shown various biological activities like immune potentiating and antitumor activities. Bee propolis extract is one of the most promising
TACG_A_261737 255..266

1Institute of Medical and Biomedical Education, St. George’s, University of London, London, UK; 2Department of Oncogenomics, Institute of Cancer Research, London, UK; 3Department of Clinical Genetics, St George’s University Hospitals NHS Foundation Trust, London, UK Abstract: BRCA2 is the most commonly implicated DNA damage repair gene associated with inherited prostate cancer. BRCA2 deficient prostate cancer typically presents at a younger age, is more poorly differentiated, and is associated with worse survival outcomes than non-BRCA2 associated prostate cancer. Despite these unfavourable prognostic implications, poly-ADP ribose polymerase inhibitors and platinum-based chemotherapy have been identified as potent targeted therapeutic agents towards BRCA1/2 deficient cancer cells. This review article explores the literature surrounding BRCA2-related prostate cancer through a familial clinical scenario. The investigation, diagnosis and management of BRCA2 deficient prostate cancer will be explored, alongside the implications of the identification of a germline pathogenic BRCA2 variant within a family, cascade screening and prostate cancer surveillance in unaffected male BRCA2 carriers. A greater understanding of the molecular pathogenesis of DNA damage repair gene deficient prostate cancer, coupled with new treatment paradigms and widened access to both somatic and germline genetic analysis for prostate cancer patients and their families will hopefully enable the robust implementation of high quality evidence-based clinical pathways for both the management and identification of BRCA2 deficient prostate cancer and improved screening, early detection and prevention strategies for individuals at increased genetic risk of prostate cancer.
CHICKEN PERFORMANCE, FEEDING, MAJOR DISEASE INCIDENCE, AND HYGIENE IN TWO LOW-INPUT POULTRY PRODUCTION SYSTEMS IN THE RURAL SECTOR OF FAYOUM GOVERNORATE

The current study covered a total of 121 households located in 12 villages within 6 districts in Fayoum governorate. The data was collected during the period from March to August, 2007 through semi-structured interviews with questionnaires. Tow systems were identified: 1) the traditional backyard (38% of the sample), and 2) the landless household (34% of the sample). In addition 28% of the sample was classified as small commercial farms. The recent paper discusses only the first two systems since the third system was found to be different in nature, objectives and management level. Most of the chickens (59 %) are dual-purpose, and were less than 6 months and aimed in general at meat production. Low performance is the major phenomenon in the rural poultry production systems where the local chickens attain maturity slowly and laying age is delayed in addition to low hatchability rate and high mortality rate of about 20 %. There was a significant difference (P< 0.01) in female age at onset, male weight at sexual maturity, and the Length of production period between traditional and landless poultry production systems in advantage to the first. Household kitchen waste is the main type of feed given to chickens. Equal incidences of disease were observed between the two studied systems. Diarrhea was the major disease. The X 2 test was significant (P< 0.05) only with regard to ways of chicken disposal, and incidence of respiratory diseases.
Horizon2020 ReFreeDrive Project: Rare Earth Free e-Drives featuring low cost manufacturing

EU-Horizon2020 funded project ReFreeDrive focuses on innovative electric motor designs for automotive industry completely free of rare earth magnets. Compared with the benchmark motors and manufacturers within the electric vehicles industry, ReFreeDrive motors are expected to improve specific torque and specific power by 30%, with a 50% increase in maximum operating speed and power density in power electronics, while halving motor losses. Two technologies, fabricated and die cast induction motor, and synchronous reluctance motor with and without ferrite permanent magnets assistance were analyzed for 200kW and 75kW power levels. Electromagnetic, thermal and mechanical performances of each motor have been optimized for each case, in order to fulfill industry requirements. Low manufacturing cost and reduction of the use of materials have been considered during the design stage, which allowed achieving 15% lower production cost. Prototypes of each kind of motor will be manufactured and tested before the end of the project.
PCR-Based Detection and Identiﬁcation of Burkholderia cepacia Complex Pathogens in Sputum from Cystic Fibrosis Patients

PCR ampliﬁcation of the recA gene followed by restriction fragment length polymorphism (RFLP) analysis was investigated for the rapid detection and identiﬁcation of Burkholderia cepacia complex genomovars directly from sputum. Successful ampliﬁcation of the B . cepacia complex recA gene from cystic ﬁbrosis (CF) patient sputum samples containing B . cepacia genomovar I, Burkholderia multivorans , B . cepacia genomovar III, Burkholderia stabilis , and Burkholderia vietnamiensis was demonstrated. In addition, the genomovar identiﬁca-tions determined directly from sputum were the same as those obtained after selective culturing. Sensitivity experiments revealed that recA -based PCR could reliably detect B . cepacia complex organisms to concentrations of 10 6 CFU g of sputum (cid:1) 1 . To fully assess the diagnostic value of the method, sputum samples from 100 CF patients were screened for B . cepacia complex infection by selective culturing and recA -based PCR. Selective culturing identiﬁed 19 samples with presumptive B . cepacia complex infection, which was corroborated by phenotypic analyses. Of the culture-positive sputum samples, 17 were also detected directly by recA -based PCR, while 2 samples were negative. The isolates cultured from both recA -negative sputum samples were subse-quently identiﬁed as Burkholderia gladioli . RFLP analysis of the recA amplicons revealed 2 patients (12%) infected with B . multivorans , 11 patients (65%) infected with B . cepacia genomovar III-A, and 4 patients (23%) infected with B . cepacia genomovar III-B. These results demonstrate the potential of recA -based PCR-RFLP analysis for the rapid detection and identiﬁcation of B . cepacia complex genomovars directly from sputum. Where the sensitivity of the assay proves a limitation, sputum samples can be analyzed by selective culturing followed by recA -based analysis of the isolate.
STOCHASTIC MODELING IN NANOSCALE BIOPHYSICS: SUBDIFFUSION WITHIN PROTEINS

Advances in nanotechnology have allowed scientists to study biological processes on an unprecedented nanoscale molecule-by-molecule basis, opening the door to addressing many important biological problems. A phenomenon observed in recent nanoscale single-molecule biophysics experiments is subdiffusion, which largely departs from the classical Brownian diffusion theory. In this paper, by incorporating fractional Gaussian noise into the generalized Langevin equation, we formulate a model to describe subdiffusion. We conduct a detailed analysis of the model, including (i) a spectral analysis of the stochastic integro-differential equations introduced in the model and (ii) a microscopic derivation of the model from a system of interacting particles. In addition to its analytical tractability and clear physical underpinning, the model is capable of explaining data collected in ﬂuorescence studies on single protein molecules. Excellent agreement between the model prediction and the single-molecule experimental data is seen.