Miracle-dz/UniFAR-FTUs huggingface dataset:
Pediatric tele-coaching fidelity evaluation: Feasibility, perceived satisfaction and usefulness of a new measure

Background To promote and ensure coaches' fidelity in delivering an online health coaching program to parents of children with suspected developmental delay, we developed and implemented a novel coaching fidelity rating tool, CO-FIDEL (COaches Fidelity in Intervention DELivery). We aimed to (1) Demonstrate CO-FIDEL's feasibility in evaluating coaches' fidelity and its change over time; and (2) Explore coaches' satisfaction with and usefulness of the tool. Methods In an observational study design, coaches (n = 4) were assessed using the CO-FIDEL following each coaching session (n = 13–14 sessions/parent-participant) during the pilot phase of a large randomized clinical trial involving eleven (n = 11) parent-participants. Outcome measures included subsections' fidelity measures, overall coaching fidelity, and coaching fidelity changes over time analyzed using descriptive and non-parametric statistics. In addition, using a four-point Likert Scale and open-ended questions, coaches were surveyed on their satisfaction and preference levels, as well as facilitators, barriers, and impacts related to the use of CO-FIDEL. These were analyzed using descriptive statistics and content analysis. Results One hundred and thirty-nine (n = 139) coaching sessions were evaluated with the CO-FIDEL. On average, overall fidelity was high (88.0 ± 6.3 to 99.5 ± 0.8%). Four coaching sessions were needed to achieve and maintain a ≥ 85.0% fidelity in all four sections of the tool. Two coaches showed significant improvements in their coaching skills over time in some of the CO-FIDEL sections (Coach B/Section 1/between parent-participant B1 and B3: 89.9 ± 4.6 vs. 98.5 ± 2.6, Z = −2.74, p = 0.00596; Coach C/Section 4/between parent-participant C1 and C2: 82.4 ± 7.5 vs. 89.1 ± 4.1, Z = −2.66; p = 0.00758), and in overall fidelity (Coach C, between parent-participant C1 and C2: 88.67 ± 6.32 vs. 94.53 ± 1.23, Z = −2.66; p = 0. 00758). Coaches mainly reported moderate-high satisfaction with and usefulness of the tool, and pointed out areas of improvement (e.g., ceiling effect, missing elements). Conclusions A new tool ascertaining coaches' fidelity was developed, applied, and shown to be feasible. Future research should address the identified challenges and examine the psychometric properties of the CO-FIDEL.
Enhancing genetic gain through the application of genomic selection in developing irrigated rice for the favorable ecosystem in Bangladesh

Increasing selection differential and decreasing cycle time, the rate of genetic improvement can be accelerated. Creating and capturing higher genetic with higher accuracy within the shortest possible time is the prerequisite for enhancing genetic gain for any trait. Comprehensive yield testing at multi-locations at early generations together with the shortest line fixation time can expedite the rapid recycling of parents in the breeding program through recurrent selection. Genomic selection is efficient in capturing high breeding value individuals taking additive genetic effects of all genes into account with and without extensive field testing, thus reducing breeding cycle time enhances genetic gain. In the Bangladesh Rice Research Institute, GS technology together with the trait-specific marker-assisted selection at the early generation of RGA-derived breeding lines showed a prediction accuracy of 0.454–0.701 with 0.989–2.623 relative efficiency over the four consecutive years of exercise. This study reports that the application of GS together with trait-specific MAS has expedited the yield improvement by 117 kg ha−1·year−1, which is around seven-fold larger than the baseline annual genetic gain and shortened the breeding cycle by around 1.5 years from the existing 4.5 years.
State and parameter estimation for robotic manipulators using force measurements

The need to equip robotic systems with a high degree of dexterity and adaptability to a wide range of precise manipulation tusks has given rise to increasing interest in the utilization of various sensing modalities, including force and tactile sensing. In this paper a general framework is proposed for incorporating both a priori task geometry information and on-line observations, including force measurements, into an optimal estimation algorithm. The output of the algorithm is state and parameter estimates that serve to disambiguate the task geometry and can be used to dynamically adapt subsequent motions. The problem is formulated us a nonlinear constrained dynamical system, including Coulomb friction between the system and the constraints. The constraint surface is described with respect to some unknown parameters representing the geometric uncertainty. The noisy on-line state and force observations are expressed as functions of the state and surface parameters. The extended Kalman filter is then used to produce optimal estimates of the state and surface parameters.
One-dimensional delta -potential in external fields

The 1D delta -potential with strength Omega in an external in-plane magnetic field B is considered theoretically. Energy dependences on Omega and d (with d being normalized to the magnetic radial rB=(h(cross)/eB)1/2 distance between the delta -potential and the vertex of the magnetic parabola) are calculated and analysed in detail in the whole ranges of d and Omega . It is shown that at d=djk the jth Landau level is not affected by the presence of the potential, where djk are the zeros of the jth-degree Hermite polynomial. For d=0, every excited even level with number j changes its energy normalized to h(cross) omega B ( omega B is the cyclotron frequency) from j- 1/2 at Omega =- infinity through j+ 1/2 at Omega =0 to j+3/2 ( Omega =+ infinity ). However, the ground-state energy asymptotically tends to - infinity while Omega varies from + infinity to - infinity . A simple physical explanation of the results obtained is given. Anticrossings of the levels in the dispersion relations are investigated for all values of Omega . For fixed positive (negative) Omega , every jth level (j=0, 1, .) has, on the d axis, j minima (maxima) with absolute value j+ 1/2 , which are achieved at djk. It is derived that, in the anticrossing picture, gaps between levels at the points djk decrease on increase in mod Omega mod , and levels cross at Omega =+or- infinity . For large negative Omega a picture of the interaction of the ground state with excited levels is given. The proposed model with the simplest modification is used to investigate the combined influence of the crossed electric and magnetic fields. This problem enables comparison with earlier results for a delta -like quantum object in a uniform electric field.
Pulse diffraction by a step discontinuity

The uniform geometrical theory of diffraction (GTD) is used to obtained a frequency-domain solution for acoustic point-source diffraction by a 90 degrees C step in a plane-surface with a hard boundary condition. The time-domain solution is then construction for an appropriate seismic pulse in which the low-frequency components are suppressed and the results presented in a form for geophysical interpretation. It is noted that results generated using the solutions thus obtained are in better agreement with experiment than numerical values based on the Kirchhoff method. <<ETX>>
The spectra of narrow-line Seyfert 1 galaxies

Measurements are presented of a group of active galactic nuclei with all the properties of Seyfert 1 or 1.5 galaxies, but with unusually narrow H I lines. They include Mrk 42, 359, and 1239 (previously studied by other authors) as well as Mrk 493, 766, 783, and 1126. One other somewhat similar object, Mrk 1388, is also included in the discussion; measurements of its spectrum have been published previously. These narrow-line Seyfert 1 galaxies show a wide variety of deviations from the properties of typical Seyfert 1 objects. They clearly demonstrate that the Seyfert phenomenon is not a simple one-parameter effect. 29 references.
Lower bounds for the eigenvalues of the fixed vibrating membrane problems

which was proved by him in case of space-covering domains Q. That is, an infinity of domains congruent to Q cover the whole space R without gaps and without overlapping except a set of measure zero. Here the positive constant Cn is An a)-, con = n /r((n/2) + 1) is the volume of the unit ball and Vol (Q) is the volume of Q. The conjecture of Polya is closely related to H. Weyl's asymptotic formula (cf. [10])
Chaotic advection in three-dimensional stationary vortex-breakdown bubbles: šil'nikov's chaos and the devil's staircase

We study the motion of non-diffusive, passive particles within steady, three-dimensional vortex breakdown bubbles in a closed cylindrical container with a rotating bottom. The velocity fields are obtained by solving numerically the three-dimensional Navier–Stokes equations. We clarify the relationship between the manifold structure of axisymmetric (ideal) vortex breakdown bubbles and those of the three-dimensional real-life (laboratory) flow fields, which exhibit chaotic particle paths. We show that the upstream and downstream fixed hyperbolic points in the former are transformed into spiral-out and spiral-in saddles, respectively, in the latter. Material elements passing repeatedly through the two saddle foci undergo intense stretching and folding, leading to the growth of infinitely many Smale horseshoes and sensitive dependence on initial conditions via the mechanism discovered by šil'nikov (1965). Chaotic šil'nikov orbits spiral upward (from the spiral-in to the spiral-out saddle) around the axis and then downward near the surface, wrapping around the toroidal region in the interior of the bubble. Poincaré maps reveal that the dynamics of this region is rich and consistent with what we would generically anticipate for a mildly perturbed, volume-preserving, three-dimensional dynamical system (MacKay 1994; Mezić & Wiggins 1994a). Nested KAM-tori, cantori, and periodic islands are found embedded within stochastic regions. We calculate residence times of upstream-originating non-diffusive particles and show that when mapped to initial release locations the resulting maps exhibit fractal properties. We argue that there exists a Cantor set of initial conditions that leads to arbitrarily long residence times within the breakdown region. We also show that the emptying of the bubble does not take place in a continuous manner but rather in a sequence of discrete bursting events during which clusters of particles exit the bubble at once. A remarkable finding in this regard is that the rate at which an initial population of particles exits the breakdown region is described by the devil's staircase distribution, a fractal curve that has been already shown to describe a number of other chaotic physical systems.
Histone Deacetylases (HDACs): Promising Biomarkers and Potential Therapeutic Targets in Thymic Epithelial Tumors

Histone deacetylases (HDACs) are core epigenetic factors, with pivotal roles in the regulation of various cellular procedures, and their deregulation is a major trait in the acquisition of malignancy properties. In this study we attempt the first comprehensive evaluation of six class I (HDAC1, HDAC2, HDAC3) and II HDACs (HDAC4, HDAC5, HDAC6) expression patterns in thymic epithelial tumors (TETs), with the aim of identifying their possible association with a number of clinicopathological parameters. Our study revealed higher positivity rates and expression levels of class I enzymes compared to class II. Sub-cellular localization and level of staining varied among the six isoforms. HDAC1 was almost exclusively restricted to the nucleus, while HDAC3 demonstrated both nuclear and cytoplasmic reactivity in the majority of examined specimens. HDAC2 expression was higher in more advanced Masaoka–Koga stages, and displayed a positive correlation with dismal prognoses. The three class II HDACs (HDAC4, HDAC5, HDAC6) exhibited similar expression patterns, with predominantly cytoplasmic staining, that was higher in epithelial rich TETs (B3, C) and more advanced tumor stages, while it was also associated with disease recurrence. Our findings could provide useful insights for the effective implementation of HDACs as biomarkers and therapeutic targets for TETs, in the setting of precision medicine.
Experimental investigation of elliptically polarized injection-locked VCSELs

Polarization switching (PS) between linear polarizations of a vertical-cavity surface-emitting laser (VCSEL) can appear when this device is subject to orthogonal optical injection. In this type of injection the injected field has a linear polarization orthogonal to that of the free-running VCSEL. In this situation interesting nonlinear dynamics appear, one of which is the existence of an injection-locked solution for which the two linear polarized modes of the VCSEL lock to the master laser frequency. This situation has been theoretically predicted and corresponds to an elliptically polarized injection-locked (EPIL) state. In this paper we report an experimental investigation of the dynamics of a long-wavelength single-transverse mode VCSEL subject to orthogonal optical injection. The free-running VCSEL emits a linearly polarized beam in the so called “parallel” direction. The polarization of the injected light is perpendicular to this state and is termed “orthogonal” polarization. We observe the EPIL state when the frequency of the orthogonal injected light is near the frequency of the parallel polarization. The spectral feature of the EPIL state is verified and the power of each polarization is measured. The EPIL region is measured in the frequency detuning-injected power plane. As current decreases, the frequency detuning range for the EPIL to exist is narrower and shifts toward the negative frequency detuning. Periodic dynamics in which both polarizations oscillate with a frequency very close to the relaxation oscillation frequency is found above the upper boundary of the EPIL region. Below the lower boundary of the EPIL zone, periodic dynamics is found only in the parallel polarization.
Magnetic fields in the Hydra A cluster

Sensitive, high-resolution VLA polarimetric observations are presented for the radio galaxy Hydra A, an outstanding example of a high-luminosity radio source embedded within a cooling flow cluster. We find extremely high Faraday rotation measures (RMs), throughout the central regions of this source, with a strong asymmetry between the north and south lobes. Simple models for the high RMs are discussed and compared with the observations. To explain the north-south asymmetry in RM requires a magnetic field of strength ∼6 μG organized over a scale of ∼100 kpc. On smaller scales we find a tangled magnetic field with a strength of ∼30 μG
Construction and Characteristics of a Kind of Four-Dimensional Vector Wavelet Packets with Four-Scale Dilation

In this paper, we introduce a class of vector-valued wavelet packets of space , which are generalizations of multivariate wavelet packets. A procedure for constructing a class of biorthogonal vector-valued wavelet packets in higher dimensions is presented and their biorthogonality properties are characterized by virtue of matrix theory, time-frequency analysis method, and operator theory. Three biorthogonality formulas regarding these wavelet packets are derived. Moreover, it is shown how to gain new Riesz bases of space from these wavelet packets.
Neuropsicologia de los trastornos de ansiedad

Si bien existe cierta diversidad terminológica y conceptual respecto a la ansiedad, desde una conceptualización multidimensional se la considera como un estado emocional complejo, difuso y aversivo que se caracteriza por una aprensión excesiva irracional, intranquilidad, tensión, hipervigilancia y preocupación, acompañada de la activación del sistema nervioso autónomo en ausencia de un estímulo específico que la desencadene. Sin embargo, esta respuesta emocional que inicialmente es adaptativa se puede convertir en patológica y es aquí donde aparecen los trastornos de ansiedad que se caracterizan por presentar una dificultad para percibir los aspectos seguros de las situaciones de peligro y por una tendencia a subestimar las capacidades de afrontamiento. El objetivo de este trabajo es realizar una revisión del concepto de ansiedad y los trastornos asociados a ella desde una perspectiva neuropsicológica, explorándola desde las diferentes escuelas psicológicas hasta su estudio también desde una mirada neurobiológica. De esta manera, se realiza una distinción entre la ansiedad y el miedo y se enfatiza en la diferenciación entre ansiedad normal y ansiedad patológica. Por último, se analiza el impacto que tiene la ansiedad en el funcionamiento cognitivo y se destaca la importancia de su tratamiento.
Diffuse Myocardial Fibrosis on Cardiac Magnetic Resonance Imaging Is Related to Galectin-3 and Predicts Outcome in Heart Failure

Aims: Ongoing adverse remodeling is a hallmark of heart failure (HF), which might be reflected by either focal or diffuse myocardial fibrosis. Therefore, in (pre)clinical settings, we used immunohistochemistry or cardiac magnetic resonance imaging (CMR) to investigate the association of (focal or diffuse) fibrosis with cardiac biomarkers and adverse events in HF. Methods and results: In C57Bl/6J mice, we determined the presence and extent of myocardial fibrosis 6 weeks post-myocardial infarction (MI). Furthermore, we studied 159 outpatient HF patients who underwent CMR, and determined focal and diffuse fibrosis by late gadolinium enhancement (LGE) and post-contrast T1 time of the non-LGE myocardium, respectively. HF patients were categorized based on the presence of LGE, and by the median post-contrast T1 time. Kaplan–Meier and Cox regression analyses were used to determine the association of fibrosis with HF hospitalization and all-cause mortality. LGE was detected in 61 (38%) patients. Cardiac biomarker levels were comparable between LGE-positive and LGE-negative patients. LGE-positive patients with a short T1 time had elevated levels of both NT-proBNP and galectin-3 (1611 vs. 453 ng/L, p = 0.026 and 20 vs. 15 μg/L, p = 0.004, respectively). This was not observed in LGE-negative patients. Furthermore, a short T1 time in LGE-positive patients was associated with a higher risk of adverse events (log-rank p = 0.01). Conclusion: This study implies that cardiac biomarkers reflect active remodeling of the non-infarcted myocardium of patients with focal myocardial scarring. Diffuse fibrosis, in contrast to focal scarring, might have a higher prognostic value regarding adverse outcomes in HF patients.
Microbial Biocontrol in the Agri-Food Industry

In recent years there has been a growing interest in the use of natural antimicrobial compounds to limit or avoid the use of chemical antimicrobials. Natural antimicrobial compounds can come from plants (essential oils) or from microorganisms (bacteriocins, mycocines, and active peptides). Despite a wide range of possible applications, their exploitation at the industrial level is still limited and needs to be investigated. The actual and possible applications of natural antimicrobial compounds in agri-food are a growing research field. In addition to the use of antimicrobial compounds, microorganisms themselves can be used in the control of spoilage microorganisms along the entire production chain of the agri-food industry. Likewise, the papers collected in this Special Issue indicate the fast development of novelties in this research field.
An Exchange Rate Policy Rule

This paper introduces a novel monetary policy framework where the exchange rate becomes the central instrument. Using Singapore as a case study, it explores the Monetary Authority's adoption of the exchange rate as the primary tool since 1981, diverging from conventional approaches centered on interest rates or monetary aggregates. The estimated exchange rate reaction function aligns well with actual deviations, supporting the hypothesis that Singapore's forward-looking policy rule effectively responds to inflation and output volatility, especially during economic crises. This framework offers a promising alternative for countries with open economies and challenges in implementing traditional interest rate instruments.
Primary Health Care: Our Experience From an Urban Primary Health Care Center in Greece

This observational study reported patient data derived from the emergency files of a primary health care (PHC) center in Greece, with the aim of providing potential solutions for a well-organized, well-structured, and effective social healthcare system. This series was conducted at a single urban PHC center in Greece between August 2017 and March 2020. A total of 83,592 patient visits were registered. The mean patient age was 42.5 years (range: three months to 93 years). Demographics, presenting complaints, and the need for patients who visited the healthcare center to be referred to tertiary hospitals were examined. Further perspectives and future strategies to strengthen the national PHC system were addressed. The most common reasons for visits were pathological (33.6%), followed by general surgery (21.2%) and orthopedics (18.1%). Pediatric conditions accounted for 12% of visits, cardiological conditions accounted for 8.6%, and dental problems accounted for 6.8%. The majority of the patients (n = 81,317, 97.3%) were managed within the health center, and only 2.7% of cases (n = 2275) needed to be referred to a secondary or tertiary healthcare structure. Reasons for patient referral included the severity or complexity of the patient's situation, lack of a specific medical specialty, and the unavailability of overnight laboratory tests. The PHC center remains the cornerstone of a high-quality healthcare system. A well-structured PHC unit can improve health outcomes and decongest secondary and tertiary health care.
Genome-wide association study reveals markers and candidate genes associated with growth in the rice flower carp, an economic fish species of integrated rice-fish culture in China

The rice flower carp (Cyprinus carpio) is an important fish in integrated rice-fishery farming. Here, we performed the first genome-wide association study (GWAS) for seven growth traits (including body mass, total length, body length, body height, body width, caudal-peduncle depth, and eye spacing) in 200 rice flower carp samples using 369,688 high-quality SNPs and 42,225 indels obtained by double-digest genotyping-by-sequencing (ddGBS). The morphometrics of these traits were highly correlated (Pearson’s correlation coefficients = 0.74–0.99, p < 0.001). GWAS detected 15, 5, 4, 26, 7, 16, and 17 loci significant associated (-log10P ≥ 5) with body mass, total length, body length, body width, body height, caudal-peduncle depth, and eye spacing, respectively. Subsequently, within the 50 kb upstream and downstream regions surrounding these significant loci, 38, 19, 18, 20, 52, 27, and 37 candidate genes for the seven growth traits were detected, respectively. Importantly, B6_4352672 and A8_4978825 were significantly associated with more than five growth traits. These results showed loci significantly associated with more than five growth traits will be helpful for future marker-assisted selection (MAS). Interestingly, chromosomes A8 and B25 had many loci significantly associated with growth traits, most of which were shared among multiple growth-related traits. These results indicated that chromosome A8 and B25 may be closely related to growth traits. Our findings not only help understand the genetic architecture of growth traits in fish but facilitate the identification of candidate genes for marker-assisted selection towards breeding faster-growing rice flower carp in the future.