Miracle-dz/UniFAR-FTUs huggingface dataset:
Mutation spectrum of FLT3 and significance of non‐canonical FLT3 mutations in haematological malignancy

Fms‐like tyrosine kinase 3 (FLT3) is frequently mutated in haematological malignancies. Although canonical FLT3 mutations including internal tandem duplications (ITDs) and tyrosine kinase domains (TKDs) have been extensively studied, little is known about the clinical significance of non‐canonical FLT3 mutations. Here, we first profiled the spectrum of FLT3 mutations in 869 consecutively newly diagnosed acute myeloid leukaemia (AML), myelodysplastic syndrome and acute lymphoblastic leukaemia patients. Our results showed four types of non‐canonical FLT3 mutations depending on the affected protein structure: namely non‐canonical point mutations (NCPMs) (19.2%), deletion (0.7%), frameshift (0.8%) and ITD outside the juxtamembrane domain (JMD) and TKD1 regions (0.5%). Furthermore, we found that the survival of patients with high‐frequency (>1%) FLT3‐NCPM in AML was comparable to those with canonical TKD. In vitro studies using seven representative FLT3‐deletion or frameshift mutant constructs showed that the deletion mutants of TKD1 and the FLT3‐ITD mutant of TKD2 had significantly higher kinase activity than wild‐type FLT3, whereas the deletion mutants of JMD had phosphorylation levels comparable with wild‐type FLT3. All tested deletion mutations and ITD were sensitive to AC220 and sorafenib. Collectively, these data enrich our understanding of FLT3 non‐canonical mutations in haematological malignancies. Our results may also facilitate prognostic stratification and targeted therapy of AML with FLT3 non‐canonical mutations.
Narrow-band Imaging for Detection of Neoplasia at Colonoscopy: a Meta-analysis of Data From Individual Patients in Randomized Controlled Trials.

BACKGROUND & AIMS Adenoma detection rate (ADR) is an important quality assurance measure for colonoscopy. Some studies suggest that narrow band imaging (NBI) may be more effective at detection of adenomas than white-light endoscopy (WLE) when bowel preparation is optimal. We conducted a meta-analysis of data from individual patients in randomized controlled trials that compared the efficacy of NBI to WLE in detection of adenomas. METHODS We searched MEDLINE, EMBASE, and Cochrane library databases, through April 2017, for randomized controlled trials that assessed detection of colon polyps by high-definition WLE vs NBI and from which data on individual patients was available. The primary outcome measure was ADR adjusted for bowel preparation quality. Multilevel regression models were used with patients nested within trials, and trial included as a random effect. RESULTS We collected data from 11 trials, comprising 4491 patients and 6636 polyps detected. Adenomas were detected in 952/2251 (42.3%) participants examined by WLE vs 1011/2239 (45.2%) participants examined by NBI (unadjusted odds ratio [OR] for detection of adenoma by WLE vs NBI, 1.14; 95% CI, 1.01-1.29; P=.04). NBI outperformed WLE only when bowel preparation was best: adequate preparation OR, 1.07 (95% CI, 0.92-1.24; P=.38) vs best preparation OR, 1.30 (95% CI, 1.04-1.62; P=.02). Second-generation bright NBI had a better ADR than WLE (second-generation NBI OR, 1.28; 95% CI, 1.05-1.56; P=.02), whereas first-generation NBI did not. NBI detected more non-adenomatous polyps than WLE (OR, 1.24; 95% CI, 1.06-1.44; P=.008) and flat polyps than WLE (OR, 1.24; 95% CI, 1.02-1.51; P=.03). CONCLUSIONS In a meta-analysis of data from individual patients in randomized controlled trials, we found NBI to have a higher ADR than WLE, and that this effect is greater when bowel preparation is optimal.
A Broadband Multicomponent Magnetic Probe With Improved Electric-Field Suppression Performance

This article presents a broadband multicomponent magnetic probe with improved electric-field suppression performance. First, two orthogonal sensing loops were introduced into a magnetic probe to capture simultaneously two orthogonal magnetic-field components. Then, a via array and fence were used to adjust impedance matching and restrain unwanted electromagnetic modes, respectively. In addition, shielding vias were arranged on the upper part of these loops to improve electric-field suppression performance. As a result, high electric-field suppression was obtained in the composite probe using shielding vias. Finally, the proposed magnetic probe was simulated, fabricated, and tested to verify the design’s rationality.
Estimation of Variances and Covariances Within the Allowable Parameter Space

Abstract Two computationally simple methods for estimation of variances and covariances, with estimates always within the allowable parameter space, are presented for multiple traits. Both methods involve transformations of data to convert observations into independent sets of traits. A Monte Carlo simulation comparison of eight methods for estimating variances and covariances was conducted. The two proposed methods compared favorably with a general purpose restricted maximum likelihood method. However, one of the methods was slow to converge and requires additional work to make it more useful.
Regulation of the unfolded protein response in yeast by oxidative stress

In the unfolded protein response (UPR), Ire1 activates Hac1 to coordinate the transcription of hundreds of genes to mitigate ER stress. Recent work in Caenorhabditis elegans suggests that oxidative stress inhibits this canonical Ire1 signalling pathway, activating instead an antioxidant stress response. We sought to determine whether this novel mode of UPR function also existed in yeast, where Ire1 has been best characterized. We show that the yeast UPR is also subject to inhibition by oxidative stress. Inhibition is mediated by a single evolutionarily conserved cysteine, and affects both luminal and membrane pathways of Ire1 activation. In yeast, Ire1 appears dispensable for resistance to oxidative stress and, therefore, the physiological significance of this pathway remains to be demonstrated.
Gettering of copper by bulk stacking faults and punched‐out dislocations in Czochralski‐grown silicon

The characteristics of Cu precipitation on various types of defects associated with oxygen precipitation in Czochralski‐grown silicon are investigated by transmission electron microscopy and the electron‐beam‐induced‐current technique. Specimens containing dominantly either punched‐out dislocations or bulk stacking faults were intentionally contaminated with Cu at various temperatures and cooled at three different rates. Colonies of Cu precipitates developed irrespective of cooling rate, apparently originating from punched‐out dislocations developed around oxygen precipitates. In heavily contaminated specimens cooled fast from the contamination temperature, Cu also precipitates on Frank partial dislocations bounding stacking faults. During slow cooling, precipitation of Cu takes place on Frank partials only in lightly contaminated specimens but never in heavily contaminated specimens. Cu precipitates in colonies are thermally more stable than those formed on Frank partials. It is concluded that punched‐ou.
Submillimeter studies of main-sequence stars

JCMT maps of the 800-micron emission from Vega, Fomalhaut, and Beta Pictoris are interpreted to indicate that they are not ringed by large reservoirs of distant orbiting dust particles that are too cold to have been detected by IRAS. A search for 800-micron emission from stars in the Pleiades and Ursa Majoris open clusters is reported. In comparison with the mass of dust particles near T Tauri and Herbig Ae stars, the JCMT data indicate a decline in dust mass during the initial 3 x 10 exp 8 yr that a star spends on the main sequence that is at least as rapid as (time) exp -2. It is estimated that in the Kuiper belt the ratio of total mass carried by small particles to that carried by comets is orders of magnitude smaller than this ratio is 1 AU from the sun. If 800-micron opacities calculated by Pollack et al. (1993) are correct, then the particles with radii less than 100 microns that dominate the FIR fluxes measured by IRAS cannot entirely account for the measured 800-micron fluxes at Vega, Beta Pic, and Fomalhaut; larger particles must be present as well.
Stress analysis of Mo, MoSi2 and Si mono-layer thin films and multilayers prepared by magnetron sputtering

To improve the stress property of multilayer optics working in extreme ultraviolet and x-ray range, mono-layer thin films of Mo, MoSi2, Si, with thickness of 100nm, and periodic multilayers of [Mo/Si]20, [MoSi2/Si]20, with period thickness of 20nm, were prepared by direct current magnetron sputtering method. Before and after each deposition, the radius of surface curvatures of substrates were measured using a stylus profiler and then the film stress was calculated. The measurement results indicate that, Mo, MoSi2 and Si mono-layer thin films all shows compressive stress, while Mo/Si multilayer shows tensile stress, i.e., the film stress changes significantly during Mo/Si multilayer growth. For MoSi2/Si multilayer, the film stress still keeps compressive, which indicates more stable stress property.
Modeling and analysis of optical test of digital camera based on orthoperspective theory

Digital camera is a very effective equipment of untouched optical test in large-visual imagines collection. However, it also has some differences between camera optical system and perspective projection. So it causes different extent of nonlinearity-optical distortion between theory imagines and actual imagines which projected on imagine plane of camera. It's necessary to rectify imagine distortion to improve veracity of imagine test and mode matching. Orthographic projection, weak perspective and paraperspective projection were major researched models in most of former theses. The former models ignore two important indexes of object and the last model has a theory problem about an angle of incidence. Comparing with theory imagines, the actual imagines of three models have large distortion. This paper brings forward a new model which based on orthoperspective model. First, revolving the light axes till it perpendicular to a plane of centroid. Second, we draw projection curves which based on orthographic projection theory. This model proves the main factors of orthoperspective distortion are revolving angle and camera foci. This model both takes fully use of object indexes and has solved problem about incidence angle. By numerical simulation and experiment, in most of measurement orthoperspective model has least imagine distortion and projection closest to theory imagine. If an object has average density and some height, taking this model can enhance measure precision.
Derivatives estimation for 2D digital data points

In this note we shall develop a simple, effective algorithm to estimate the first and the second partial derivatives for 2D digital data points. First, we shall follow the ideas given in Chen, Chi and Wu (2005) to define the discrete gradient of a function on a 2D digital data. Our method will work for boundary points. This will allow us shall define the Laplace operator acting on functions on the 2D digital data. Some numerical results will be presented to show our algorithm is very accurate.
On the use of simulated photon paths to co‐register top‐of‐atmosphere radiances in EarthCARE radiative closure experiments

The Earth's Cloud, Aerosol and Radiation Explorer (EarthCARE) mission will retrieve vertical profiles of cloud and aerosol properties by combining data from active and passive instruments. The verisimilitude of retrievals will be assessed using data from its broad‐band radiometer (BBR), which measures top‐of‐atmosphere (TOA) short‐wave (SW) radiances at three along‐track viewing angles. BBR measurements will be compared with their modelled counterparts, simulated by a three‐dimensional (3D) Monte Carlo (MC) radiative transfer model acting on retrieved properties, thus defining a radiative closure experiment. Since cloud and aerosol microphysical and hence optical properties within each assessment domain vary horizontally and vertically, one challenge facing the closure process is selection of radiances that will foster the best assessments of retrievals. This study investigates whether co‐registration of radiances for closure assessment can be aided by information pertaining to photon paths from the MC model. Unlike methods that provide one effective reflecting layer (ERL), such as cloud‐top altitude, simulated photon paths can account for several reflecting layers. For this study, A‐Train satellite data provided cloud properties. The MC model was applied to this field to simulate BBR‐like measurements. Cloud properties were then perturbed randomly, to represent retrievals in approximate fashion, and the MC model reapplied to them. The resulting sets of radiances mimicked EarthCARE measured and modelled data, thus allowing a test of closure and co‐registration methodologies. Through the use of 3D photon path information, the rate of identification of inaccurate cloud retrievals improved over ERL approaches by ∼4% for cirrus clouds and ∼15% for broken clouds. For large‐scale deep convective clouds, however, inaccurate photon paths, ostensibly due to poor retrievals, reduced identification performance by 3%.
Electrohydrodynamic printing under applied pole-type nozzle configuration

A pole-type nozzle has an inserted pole that jams a contraction flow into capillary in electrohydrodynamic deposition. The jammed solution improves Taylor cone formation by shortening the hysteresis time so that pole-type nozzle is suitable for high-resolution electrohydrodynamic printing. Experimental results demonstrate a governed frequency-dividing relationship with an integral ratio of applied voltage frequency to droplet deposition frequency. It is observed that low integral frequency ratio is in favor of low voltage amplitude and duty cycle, and high voltage frequency, since polymer solution jets in a small fluidic volume per droplet under low electric force and short pulse duration.
Low-complexity bit-parallel systolic architecture for computing AB/sup 2/+C in a class of finite field GF(2/sup m/)

An algorithm for computing AB/sup 2/+C over a finite field GF(2/sup m/) is presented using the properties of the irreducible all one polynomial of degree m. Based on the algorithm, a parallel-in parallel-out systolic multiplier is proposed. The architecture of the multiplier is very simple, regular, modular, and exhibits very low latency and propagation delay. Therefore, it is suitable for very large scale integration implementation of cryptosystems.
On the omnidirectional radiation via radially anisotropic zero-index metamaterials

By a comprehensive mathematical derivation, we show that the underlying physics of realizing a two-dimensional omnidirectional radiation from multiple sources via radially anisotropic zero-index metamaterials (RAZIM), as numerically and experimentally demonstrated in Cheng Q. et al., Phys. Rev. Lett. , 108 (2012) 213903, lies in that the RAZIM shell confines all anisotropic cylindrical modes within the shell, while keeping transparent to isotropic cylindrical modes. From the illustrated underlying physics, it follows straightforwardly that it is impossible to use the RAZIM for generating perfectly coherent isotropic radiation in a three-dimensional free space, contrary to the claim made in the above-mentioned reference.
Droplet splashing on a thin liquid film

We propose a theory predicting the transition between splashing and deposition for impacting drops. This theory agrees with current experimental observations and is supported by numerical simulations. It assumes that the width of the ejected liquid sheet during impact is precisely controlled by a viscous length l ν . Numerous predictions follow this theory and they compare well with recent experiments reported by Thoroddsen [J. Fluid Mech. 451, 373 (2002)].
Does Arthroscopic Suture-Spanning Augmentation of Single-Row Repair Reduce the Retear Rate of Massive Rotator Cuff Tear?

Background: Several surgical techniques have been proposed for massive rotator cuff tears (MRCTs), but the failure rates remain high. The suture-spanning augmentation technique of single-row (SSA-SR) repair was shown to reduce failure rates in cadaveric studies, but the outcome in vivo remains unclear. Purpose: To determine if adding spanning sutures to SR repair during MRCT repairs can improve functional outcome and reduce failure rates. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: The study included 71 patients with a diagnosed MRCT. The study group (n = 35) received SSA-SR repair. The control (n = 36) received SR repair. The American Shoulder and Elbow Surgeons (ASES) score, Constant score, UCLA (University of California, Los Angeles) score, and visual analog scale for pain were assessed preoperatively and 24 months postoperatively. Magnetic resonance imaging was arranged at 6 months postoperatively to evaluate the rotator cuff. Results: At 6 months postoperatively, the overall retear rate was 31.0%. The retear rate was lower in the SSA-SR group (14.3%) than in the SR group (47.2%, P = .002). At 24 months, the SSA-SR group had markedly improved ASES, Constant, and UCLA scores in comparison with the SR group (P < .05). Within both groups, all scores had significant improvement as compared with the preoperative status (P < .05). Conclusion: The SSA-SR repair technique showed improved functional and radiologic results. Based on the superior postoperative outcome of this technique, the SSA-SR repair technique can be a potential treatment option for MRCT repair. Registration: NCT03609164 (ClinicalTrials.gov identifier).
A Stochastic Transformation Field Theory for Heterogeneous Materials

The formulation of a stochastic transformation field analysis framework is presented. The theory introduces the statistics of the underlying material microstructure through the incorporation of probability density functions (PDFs) for the mechanical and transformation field concentration tensors for the phases. Thus, this approach represents a departure from the practice in current micromechanical stochastic theories of considering PDFs for the distributions in the spatial arrangements in the microstructure. General equations governing the behavior of the concentration tensors in the presence of arbitrary variations in these tensors as well as other fields (such as the stress, strain, and eigenfields) are developed. The resulting framework is subsequently specialized to two-phase composite materials. It is shown in this case that the amount of stochastic information required by the theory can be substantially reduced. In particular, only stochastic information about the mechanical concentration tensors is.
A Miniaturized Full-Ground Dual-Band MIMO Spiral Button Wearable Antenna for 5G and Sub-6 GHz Communications

A detachable miniaturized three-element spirals radiator button antenna integrated with a compact leaky-wave wearable antenna forming a dual-band three-port antenna is proposed. The leaky-wave antenna is fabricated on a denim (εr = 1.6, tan δ = 0.006) textile substrate with dimensions of 0.37 λ0 × 0.25 λ0 × 0.01 λ0 mm3 and a detachable rigid button of 20 mm diameter (on a PTFE substrate εr = 2.01, tan δ = 0.001). It augments users’ comfort, making it one of the smallest to date in the literature. The designed antenna, with 3.25 to 3.65 GHz and 5.4 to 5.85 GHz operational bands, covers the wireless local area network (WLAN) frequency (5.1–5.5 GHz), the fifth-generation (5G) communication band. Low mutual coupling between the ports and the button antenna elements ensures high diversity performance. The performance of the specific absorption rate (SAR) and the envelope correlation coefficient (ECC) are also examined. The simulation and measurement findings agree well. Low SAR, <−0.05 of LCC, more than 9.5 dBi diversity gain, dual polarization, and strong isolation between every two ports all point to the proposed antenna being an ideal option for use as a MIMO antenna for communications.
Lattice Trapping of Fracture Cracks

Continuum treatments of lattice defects such as dislocations and fracture cracks do not predict the resistance to the defect mobility which is due to the Peierls energy in the case of the dislocation. The discrete character of the lattice in the case of the fracture crack leads to a stress stability range for the crack above and below the Griffith stress over which the crack is stable or ``lattice trapped''. We develop here two essentially qualitative theoretical treatments of the lattice structure of cracks. In the first, we carry out a lattice sum of the bond energies of atoms facing each other across the crack plane under certain assumptions regarding the crack shape and atomic force laws. In the second, we introduce a one‐dimensional lattice model of a crack which can be solved exactly. In both of these treatments the range of stress over which the crack is lattice trapped appears to be of the order of magnitude of the Griffith stress itself. As in the case of dislocations the lattice trapping is a st.
Nutrition and Health Programming and Outreach in Grocery Retail Settings: A Community Coalition in Action

Grocery stores can provide a conducive environment for interventions targeting healthy eating and access to health services, particularly in low-income communities. A wide array of organizations deliver nutrition and related programs in community settings, but rarely in a coordinated fashion. Collaboration of local health promotion organizations with grocery stores could increase consumers’ access to and selection of healthy foods and related services. This evaluation of the In-Store Programming and Outreach Coalition (IPOC) uses thematic analysis of first-person accounts from coalition members. To our knowledge, this is the first study of such a coalition. We present perspectives from six stakeholders about the IPOC strengths, challenges, and recommendations for strengthening the delivery of in-store interventions. Themes identified include partnership, increased client reach and cross-referrals, conflicting work schedules, leadership, and recommendations to identify coalition leaders and expand services to other grocery stores. We conclude that grocery stores can offer a suitable setting for programming and community outreach through coalitions.
The Relation Between Clinical Measurements of Plantar Characteristics and Static and Dynamic Balance Indices

System. Results: There was a significant correlation between arch height, and static and dynamic balance indices (maximum correlation coefficient = 0.46, moderate correlation coefficient); also, there was a direct significant correlation between rear and footprint angles and some other balance indices (correlation coefficient = 0.2, weak correlation). There was a significant inverse association between navicular drop and balance indices (maximum correlation coefficient = 0.3, moderate correlation coefficient). Evaluating arch and longitudinal arch angle indices by the Staheli and Denis correlation methods showed insignificant association between these variables and balance indices (P > 0.05). Conclusions: It seems that plantar changes have insignificant effect on static and dynamic indices evaluated by the Biodex Balance System.