Miracle-dz/UniFAR-FTUs huggingface dataset:
AGI January 41/1

Pausawasdi, N. , S. Ramamoorthy, V. Stepan, J. Del Valle, and A. Todisco. Regulation and function of p38 protein kinase in isolated canine gastric parietal cells. Am. J. Physiol. Gastrointest. Liver Physiol. 278: G24–G31, 2000. —We examined the regulation and functional role of p38 kinase in gastric acid secretion. p38 kinase was immunoprecipitated from cell lysates of highly purified gastric parietal cells in primary culture, and its activity was quantitated by in vitro kinase assay. Carbachol effects were doseand time-dependent, with a maximal 10-fold stimulatory effect detected after 30 min of incubation. SB-203580, a highly selective inhibitor of p38 kinase, blocked carbachol induction of p38 kinase activity, with maximal inhibition at 10 μM. Stimulation by carbachol was unaffected by preincubation of parietal cells with the intracellular Ca21 chelator BAPTA-AM, but incubation of cells in Ca21-free medium led to a 50% inhibition of carbachol induction of p38 kinase activity. Because some of the effects of carbachol are mediated by the small GTPbinding protein Rho, we examined the role of Rho in carbachol induction of p38 kinase activity. We tested the effect of exoenzyme C3 from Clostridium botulinum (C3), a toxin known to ADP-ribosylate and specifically inactivate Rho. C3 led to complete ADP-ribosylation of Rho, and it inhibited carbachol induction of p38 kinase by 50%. We then tested the effect of SB-203580 and C3 on carbachol-stimulated uptake of [14C]aminopyrine (AP). Inhibition of p38 kinase by SB203580 led to a dose-dependent increase in AP uptake induced by carbachol, with maximal (threefold) effect at 10 μM SB-203580. Similarly, preincubation of parietal cells with C3 led to a twofold increase in AP uptake induced by carbachol. Thus carbachol induces a cascade of events in parietal cells that results in activation of p38 kinase through signaling pathways that are at least in part dependent on Rho activation and on the presence of extracellular Ca21. p38 kinase appears to inhibit gastric acid secretion.
Risk of Occupational Respiratory Disorders Among Workers in Diwaniya City-Iraq

To calculate the risk of developing respiratory disorders among workers in Diwaniya, three occupational settings were included and a retrospective cohort studies were applied in two of them, while a case control study was applied in the third. Among workers exposed to air pollution by sand and cement in construction settings the relative risk was 3 times the risk among non exposed, the attributable risk was 12 more, and the attributable risk percent was 66.67%. Among workers exposed to air pollution by particulates of carbon and talc in rubber industry, the risks were: 6.67 times, 56.66 more, and 85.01% respectively. While among workers exposed to dust of cotton in textile factory the odd ratio was 12 times that of those not exposed. More supervision and revitalization of enactments related to work is needed and proper preventive health measures are to be applied for each setting.
The Influence of Project-Based Brain-Writing Learning Model to Increase the Writing Skill toward Indonesian Subject at Elementary School

DOI https://doi.org/10.15294 /ijcet.v9i1. 24785 Abstract ___________________________________________________________________ This study explained about the concept of project-based brain-writing learning model in the teaching and learning process of writing skill in Indonesian subject. Learning became the process to deliver the theory to the students through stimuli and responses. One of the aspects that were very important to determine the learning achievement was the using of learning strategy and the interactive learning media that could motivate the students in the learning process. The research has purposed to find the effect of the Brainwriting learning model based on project-based learning to improve Indonesian writing skills. The research method used an experimental method research design. The research population was five classes of Public Elementary School 1 Klegen Madiun. Analyzing the results that there is a significant effect of project-based learning brainwriting models on Indonesian writing skills. This study used a project-based brainwriting learning model that hopefully could give the easier learning process for the students.
PRBM_A_271979 1165..1180

Business, Korea University, Seoul, Republic of Korea Background: Although previous research has demonstrated that ingredient information plays a significant role in consumers’ healthier food choices, none of the research has investigated how the number of ingredients (ie, single vs multiple) influences consumer perceptions of food healthiness. However, this research argues that consumers have lay belief that the greater the number of (un)healthy ingredients in food, the more (un)healthy the food is perceived and they rely on the lay belief when judging food healthiness. Thus, this paper proposes and examines the multiple ingredients effect that people make inferences about food (un)healthiness based on the diversity of (un)healthy ingredients. Methods and Results: Four studies test our hypotheses using ANOVAs and regression analyses. Study 1 examines that people indicate a higher perception of food unhealthiness when the number of unhealthy ingredients is presented as multiple rather than single. Study 2 replicates the multiple ingredients effect in the healthy food domain and eliminates an alternative explanation based on the subadditivity effect. Study 3 also finds that the difference in food healthiness perception between people who have high and low health consciousness is driven by the salience of each ingredient. Finally, Study 4 identifies the evaluability of the nutritional value as a boundary condition for our effect in an AI-based self-service context. Conclusion: The current research demonstrates the multiple ingredients effect that people perceive higher food (un)healthiness when the number of (un)healthy ingredients is greater although nutritional information is identically presented. Moreover, this effect is moderated by the extent to which people are conscious of health-related issues. This finding is because ingredient information is highly accessible and salient for health-conscious people .
Yeast Lacking Superoxide Dismutase

Null mutants of superoxide dismutase (SOD) in Succharomyces cereuisiae are associated with a number of biochemical defects. In addition to being hypersensitive to oxygen toxicity, strains containing deletions in both the SOD1 (encoding Cu/Zn-SOD) and SOD2 (encoding Mn-SOD) genes are defective in sporulation, are associated with a high mutation rate, and are unable to biosynthesize lysine and methionine. The sodlinked defect in lysine metabolism was explored in detail and was found to occur at an early step in lysine biosynthesis, evidently at the level of the a-amino adipate transaminase. To better understand the role of SOD in cell metabolism, our laboratory has isolated yeast suppressors that have bypassed the SOD defect (“bsd” strains), that is, S. cereuisiue cells lacking SOD, yet resistant to oxygen toxicity. Two nuclear bsd complementation groups have been identified, and both suppress a variety of biological defects associated with sod1 and sod2 null mutants. These results demonstrate that a single gene mutation can alleviate the requirement for SOD in cell growth. Both bad complementation groups are unable to utilize many non-fermentable carbon sources, suggesting a possible suppressorlinked defect in electron transport.
Adjustment of sensitisation and challenge protocols restores functional and in ﬂ ammatory responses to ovalbumin in guinea-pigs and Methods

Introduction: Inhalation of antigen in atopic asthma induces early (EAR) and late asthmatic responses (LARs), in ﬂ ammatory cell in ﬁ ltration and airways hyperresponsiveness (AHR). Previously, we have established a protocol of sensitisation and subsequent ovalbumin (Ova) inhalation challenge in guinea-pigs which induced these4features(Smith&Broadley,2007). However,theresponsesofguinea-pigstoOvachallengehaverecently declined, producing no LAR or AHR and diminished EAR and cells. By making cumulative modi ﬁ cations to the protocol, we sought to restore these features. Methods: Guinea-pigs were sensitised with Ova (i.p. 100 or 150 μ g) on days 1 and 5 or days 1, 4 and 7 and challenged with nebulised Ova (100 or 300 μ g/ml, 1 h) on day 15. Airway function was measured in conscious guinea-pigs by whole-body plethysmography to record speci ﬁ c airway conductance (sGaw). Airway responsiveness to aerosolized histamine (0.3 mM) was determined before and 24 h after Ova challenge. Bronchoalveolar lavage was performed for total and differential in ﬂ ammatory cell counts. Lung sections were stained for counting of eosinophils. Results: Lack of AHR and LAR with the original protocol was con ﬁ rmed. Increasing the Ova challenge concentration from 100 to 300 μ g/ml restored AHR and eosinophils and increased the peak of the EAR. Increasing the number of sensitisation injections from 2 to 3 did not alter the responses. Increasing the Ova sensitisation concentration from 100 to 150 μ g signi ﬁ cantly increased total cells, particularly eosinophils. A LAR was revealed and lymphocytes and eosinophils increased when either the Al(OH) 3 concentration was increased or the duration between the ﬁ nal sensitisation injection andOvachallengewasextendedfrom15to21 days. Discussion: Thisstudyhasshownthatdecliningallergicre- sponses to Ova in guinea-pigs could be restored by increasing the sensitisation and challenge conditions. It has also demonstrated an important dissociation between EAR, LAR, AHR and in ﬂ ammation.
Efficient and Secure Model for Detect Malware and Fake Ranking Apps

: Nowadays most of the people using smart phones for daily activities so android apps in smart phones plays major role in the market to perform various activities. Previous works describes the information about on app executable and permission analysis. Users mostly will download apps from Google play based on ranking and review. Malware is any piece of code that is meant to cause damage to your system or network. Malware is completely different from common programs during a approach that they most of them have the flexibility to unfold itself within the network, it will damage entire system performance and network. Another issue is search fraud due to these users will change their opinions on app . In this paper we implement novel system called Fairplay to uncover malware and search rank fraud by fraudsters, it will analyze longitudinal app data. FairPlay’s PCF algorithmic rule analyzes review process and relations between various users posted reviews from dataset. We implement FairPlay in this article to detect Google Play fraud and malware. In this supervised learning techniques used to provide relational and behavioral and linguistic features, Novel system provides 95% accuracy in datasets of malware, fraudulent and accurate apps. We analyze and show experimental results that 75% of the found malware apps employ with fake rank fraud.
Vitamin D supplementation on colorectal cancer incidence and mortality:a meta-analysis of randomized controlled clinical trials and trial sequential analysis

Abstract Objective: To evaluate the effect of oral vitamin D supplementation on colorectal cancer incidence and mortality Methods: All randomized controlled trials regarding effect of oral vitamin D on colorectal cancer from PubMed,Web of science,Embase and Cochrane Library were searched. Meta analysis and trial sequential analysis of included studies were carried out. Results: Seven RCTs enrolling 72810 participants were included. Compared with placebo,oral vitamin D supplementation was not associated with the incidence of colorectal cancer(RR=1.1,95%CI:0.93-1.31;p=0.28). Subgroup analysis showed no difference in female participants for incidence of colorectal cancer(RR=1.04,95% CI:0.84-1.28;p=0.73). The pooled RR,included 41643 participants,showed no difference in mortality of colorectal cancer(RR= 0.82, 95% CI:0.56 to 1.21; p = 0.32). Trial sequential analysis showed the z-line did not cross the conventional test boundary, TSA monitoring boundary and futility boundaries . Conclusion: Oral vitamin D supplementation offers no benefit on the incidence and mortality of colorectal cancer.However,the RCTs with longer follow-up are needed to ascertain the efficacy of Vitamin D,especially among adults with lower serum 25(OH)D levels in future. Key words:vitamin D;colorectal cancer;incidence;mortality
Persistent and reversible impacts of smoking on resting-state EEG in chronic smokers and successful long-term abstainers

Smoking is a severe addictive health risk behavior and notorious for the high likelihood of relapse after attempted cessation. Such an addictive pattern in smoking has been associated with neurobiological changes in the brain. However, little is known whether the neural changes associated with chronic smoking persist after a long period of successful abstinence. To address this question, we examined resting state EEG (rsEEG) in heavy smokers who have been smoking for 20 years or more, past-smokers who have been successfully abstaining for 20 years or more, and non-smokers. Compared with chronic current- or past- smokers, non-smokers showed higher relative power in theta frequency band, showcasing long-lasting effects of smoking on the brain. A few rsEEG features in alpha frequency band also revealed reversible impacts of smoking, such that only current-smokers, but not past-smokers, showed distinctively higher patterns than non-smokers in their relative power, EEG reactivity--power changes between eyes-closed and eyes-open conditions--, and coherence between channels. Furthermore, rsEEG feature differences between current- and past- smokers were accounted for by individuals' self-reported smoking history and nicotine dependence. These data suggest long-lasting impacts of chronic smoking on the brain that are dissociable from the neural changes reversible with long-term abstinence.
Service Quality Modeling

— The paper presents the selected issues of service quality modeling. The author presents a classification of the main phenomena connected with quality from both the provider’s and the user’s point of view. It is underlined that service quality will be one of the main issues of next generation networks, like 5G, where the user’s perspective will be of a great importance. The main contribution of the paper is the presentation of the method of building the Quality of Experience (QoE) models, based on two popular services, i.e., messaging and web browsing. The author emphasizes that some existing QoE models based on average values do not reflect users’ expectations and there is a need for building new, more sophisticated models, which take into account more parameters and also their transient behaviors.
Screening and Identi cation of Key Biomarkers in Low-Grade Gliomas: Evidence from Bioinformatic Analysis

Dong He Shandong Provincial Hospital Zhen Qin Shandong University of Traditional Chinese Medicine A liated Hospital Taihong Gao Shandong Provincial Hospital Fan Yang Shandong Provincial Hospital Hua Guo Shandong Provincial Hospital Tao Xin Shandong Provincial Hospital Rui Zhang Shandong Provincial Hospital Jun Sun Shandong Provincial Hospital Qian Liu Shandong University Cheeloo College of Medicine Pang Qi (  pangqi@sdu.edu.cn ) Shandong Provincial Hospital
STUDY OF REDUCED E-CADHERIN AND POSITIVE VIMENTIN EXPRESSION AT THE INVASIVE TUMOR FRONT AND ITS ASSOCIATION WITH TUMOR STAGE AND GRADE IN PRIMARY HEAD AND NECK SQUAMOUS CELL CARCINOMA

AIMS: To study the reduced E-cadherin and positive Vimentin expression at the invasive tumor front and its association with tumor stage and grade in Head and Neck Squamous Cell Carcinomas (HNSCC). Hospital based descriptive observational cross SETTING AND DESIGN: sectional study, conducted in the Department of Pathology Lady Hardinge Medical College, New Delhi. 66 MATERIAL AND METHODS: newly diagnosed HNSCC cases between October 2015 to March 2017 were included. H&E staining and immunohistochemistry for Vimentin and E-cadherin was performed. Data was entered in SPSS version 23.0 and p<0.05 was considered as signicant. STATISCAL ANALYSIS: RESULTS: Out of 66 HNSCC cases 68.2% cases showed reduced E-cadherin expression and signicant correlation was found between reduced E-cadherin expression at invasive tumor front(p=0.011). 62.1% cases showed positive vimentin expression at ITF. But there was no correlation found with positive vimentin expression at ITF. (p=0.245) Forty one (62.12%) cases showed reduced E-cadherin and positive Vimentin expression while 20 cases (30.3%) showed preserved E-cadherin and negative vimentin expression and 5 cases (7.57%) showed reduced E-cadherin and negative vimentin expression(both negative) at ITF. Reduced E-cadherin and positive vimentin expression at ITF was seen more in TNM stage I and II (p<0.001). 65.71% patients of WDSCC and 34.28% patients with MDSCC and PDSCC showed reduced E-cadherin and positive vimentin expression at ITF which was more in well differentiated tumor (p<0.001). CONCLUSION: Reduced E-cadherin and positive vimentin expression at ITF did not correlate with prognostic factors like tumor size, lymph node involvement, higher TNM stage and higher grade of tumor.
PERFORMANCE EVALUATION AND DRIVE SELECTION FOR HYBRID ELECTRIC VEHICLES

Today’s automobile world is turning towards Electric and Hybrid Electric Vehicles (EV and HEV) due to their numerous advantages over a conventional vehicle such as reduced emissions, higher efficiency etc. Different motors are used to provide the total propulsion power for an EV and combined with engine for HEV. For these motors, various control strategies can be implemented to improve the motor performance and hence the enhanced performance of EV/HEV. In this paper, HEV model is analyzed for their performances by considering the cases of Permanent magnet Synchronous Motor (PMSM) and induction Motor (IM) drivetrains. First, the HEV models are integrated in MATLAB/SIMULINK environment along with PMSM and induction motor drives in different operating conditions. The motor controllers and supervisory controllers are appropriately tuned to achieve the required speed-torque demands and vehicle performance. The HEV model developed in LMS imagine.lab AMESim is considered to have a comparison with the results obtained with that in MATLAB/SIMULINK. The results are compared to analyze the relative performances in terms of efficiency, response and fulfilling load demands of the respective motor drives under various operating conditions. This will enable choosing the appropriate drive for the Hybrid Electric Vehicle application. Based on the comparative results appropriate motors are suggested for different requirements and under various operating conditions for HEV.
Adsorbentes no-convencionales, alternativas sustentables para el tratamiento de aguas residuales

This article shows a revision of the non-conventional absorbers employed for the removal of water pollutants. A brief description is made on the conventional absorbers in order to distinguish them from the non-conventional ones. Conventional absorbers are those natural or synthetic materials which employment is contingent with a treatment process so that they can be activated, such as carbon, clays, membranes, etc. After using these materials, they are able to be regenerated. Non-conventional absorbers are alternate materials (biopolymers or parts of plants); they should not necessarily be subject to a previous treatment to be activated; however, activation improves their absorption capacity. Sources studied for obtaining the materials employed as non-conventional absorbers include agroindustrial wastes, food industry wastes, and plant species which application is restricted or has no application at all. Different studies have shown that the employment of natural materials as non-conventional absorbers allows minimizing the organic discharge of a river contaminated with metals, dyes, pesticides, and other organic compounds known as emerging compounds. The fields of study for non-conventional materials emerge as a need for the design of sustainable process for the wastewater treatment; for this reason, the study and revision of non-conventional materials are of special interest to go deeper and propose alternative according to the existing needs.
H2 formation on interstellar dust grains The viewpoints of theory, experiments, models and observations

Molecular hydrogen is the most abundant molecule in the universe. It is the ﬁrst one to form and survive photo-dissociation in tenuous environments. Its formation involves catalytic reactions on the surface of interstellar grains. The micro-physics of the formation process has been investigated intensively in the last 20 years, in parallel of new astrophysical observational and modeling progresses. In the perspectives of the probable revolution brought by the future satellite JWST, this article has been written to present what we think we know about the H 2 formation in a variety of interstellar environments. This an the CC
VMRR_A_266350 87..98

1School of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Jimma University, Jimma, Ethiopia; 2Ethiopian Institute of Agricultural Research, Tepi Agricultural Research Center, Tepi, Ethiopia Background: The epidemiology of cattle abortion and its association with brucellosis is not well understood in Ethiopia. Therefore, the aim of this study was to determine the magnitude, associated risk factors of abortion, and its association with brucellosis in cattle of Jimma zone, Ethiopia. Methods: A cross-sectional study was carried out from October 2018 to October 2019 in Jimma zone. A total of 484 pregnant cattle were randomly selected from two districts based on the composition of the cattle population. Besides, blood samples were collected from a total of 484 randomly selected cattle to assess the presence of Brucella antibody. The presence of an antibody against Brucella organism was first tested by the Rose Bengal Plate test, and then positive serum was confirmed using the complement fixation test. Results: An overall 14.30% cumulative incidence rate of abortion was recorded in study areas. In this study, breed, herd size, method of breeding, previous history of abortion, accessibility of dog to cattle and season were identified as risk factors for the occurrence of cattle abortion. Higher cumulative incidence of abortion (31.82%) was observed in Brucella antibody positive cattle than those of antibody negative cattle (13.42%). However, the difference noted was not statistically significant (P<0.05). Conclusion: It is important to create awareness about the impact of the abortion on cattle production and the applicable control technique of abortion should be aimed and implemented. Moreover, further investigation should be conducted to identify the specific cause of abortion and the associated loss in the study areas.
Study The Effect of Iraqi Butter Ghee on Some Biochemical Parameters and Histopathological Changes on Aorta of Albino

This study designed to investigate the effects of Iraqi animal oils on aortal tissue as well as biochemical changes of lipid profiles of mice, which feeds, by these oils for six months, the result showed: There were different degrees of significant increase (p<0.05), (p<0.005), (p<0.0005)in TC,TG,LDL,VLDL , and AI, but there was high significant decrease(p<0.0005) in HDL in mice fed on Iraqi animal oils for six months if compared with control group, The histological sections of aorta were revealed presence of severe histopathological changes, which represented by increase the thickness (89.7±21.3μm) of atherosclerotic plaque in intima which formed by accumulation of lipid droplets (cholesterol, oxidized-LDL), as well as increase the thickness and fibrosis of medial layer. The most severe changes were in aorta, showing significant atherosclerosis and marked luminal narrowing which appeared as semi blocked of blood stream of the aorta of some animals as well as fibrosis and thickness of some areas in some very severe cases.