Miracle-dz/UniFAR-FTUs huggingface dataset:
C0-hybrid high-order methods for biharmonic problems

We devise and analyze $C^0$-conforming hybrid high-order (HHO) methods to approximate biharmonic problems with either clamped or simply supported boundary conditions. $C^0$-conforming HHO methods hinge on cell unknowns which are $C^0$-conforming polynomials of order $(k+2)$ approximating the solution in the mesh cells and on face unknowns which are polynomials of order $k\ge0$ approximating the normal derivative of the solution on the mesh skeleton. Such methods deliver $O(h^{k+1})$ $H^2$-error estimates for smooth solutions. An important novelty in the error analysis is to lower the minimal regularity requirement on the exact solution. The technique to achieve this has broader applicability than just $C^0$-conforming HHO methods, and to illustrate this point, we outline the error analysis for the well-known $C^0$-conforming interior penalty discontinuous Galerkin (IPDG) methods as well. The present technique does not require bubble functions or a $C^1$-smoother to evaluate the right-hand side in case of rough loads. Finally, numerical results including comparisons to various existing methods showcase the efficiency of the proposed $C^0$-conforming HHO methods.
OpSparse: A Highly Optimized Framework for Sparse General Matrix Multiplication on GPUs

Sparse general matrix multiplication (SpGEMM) is an important and expensive computation primitive in many real-world applications. Due to SpGEMM’s inherent irregularity and the vast diversity of its input matrices, developing high-performance SpGEMM implementation on modern processors such as GPUs is challenging. The state-of-the-art SpGEMM libraries (i.e., <inline-formula> <tex-math notation="LaTeX">$nsparse$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$spECK$ </tex-math></inline-formula>) adopt several algorithms to tackle the challenges of global load balance, local load balance, and allocation of the result matrix. While these libraries focus on the high-level algorithm design for SpGEMM, they neglect several low-level architecture-specific optimizations, which causes inefficient implementations in their libraries. In this paper, we classify their inefficient implementations into several categories. Based on our observations, we propose a highly optimized SpGEMM library called <inline-formula> <tex-math notation="LaTeX">$OpSparse$ </tex-math></inline-formula>. The optimizations in <inline-formula> <tex-math notation="LaTeX">$OpSparse$ </tex-math></inline-formula> include 1) optimizing the binning method by improving the utilization of the shared memory, 2) optimizing the hashing method by reducing the accesses to the hash tables, 3) improving the trade-off between hash collision rate and hardware utilization in the hashing method by setting appropriate binning ranges, 4) reducing the overheads of global memory utilization by minimizing the global memory usage of the metadata, and 5) improving the execution parallelism by overlapping global memory allocation with kernel execution. Performance evaluations with 26 commonly used matrices on an Nvidia Tesla V100 GPU show that <inline-formula> <tex-math notation="LaTeX">$OpSparse$ </tex-math></inline-formula> achieves on average <inline-formula> <tex-math notation="LaTeX">$7.35\times $ </tex-math></inline-formula> (up to <inline-formula> <tex-math notation="LaTeX">$27.8\times $ </tex-math></inline-formula>), <inline-formula> <tex-math notation="LaTeX">$1.43\times $ </tex-math></inline-formula> (up to <inline-formula> <tex-math notation="LaTeX">$1.81\times $ </tex-math></inline-formula>), and <inline-formula> <tex-math notation="LaTeX">$1.52\times $ </tex-math></inline-formula> (up to <inline-formula> <tex-math notation="LaTeX">$2.04\times $ </tex-math></inline-formula>) speedups over three state-of-the-art SpGEMM libraries: <inline-formula> <tex-math notation="LaTeX">$\mathit {cuSPARSE}$ </tex-math></inline-formula>, <inline-formula> <tex-math notation="LaTeX">$nsparse$ </tex-math></inline-formula>, and <inline-formula> <tex-math notation="LaTeX">$spECK$ </tex-math></inline-formula>, respectively.
Recent Progress in Low-Carbon Binders 1 2

eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) licence. This licence only allows you to download this work and share it with others as long as you credit the authors, but you can’t change the article in any way or use it commercially. More information and the full terms of the licence here: https://creativecommons.org/licenses/
16 Quantum Well Lasers ( advanced topic

592 During the last few years a new type of a semiconductor laser, the quantum well (QW) laser, has come to the fore [l]. It is similar in most respects to the conventional double heterostructure laser of the type shown in Figure 15-10 except for the thickness of the active layer. In the quantum well it is ~50-100 Å, while in conventional lasers it is ~1,000 Å. This feature leads to profound differences in performance. The main advantage to derive from the thinning of the active region is almost too obvious to state—a decrease in the threshold current that is nearly proportional to the thinning. This reduction can be appreciated directly from Figure 15-7. The carrier density in the active region needed to render the active region transparent is ~1018 cm-3. It follows that just to reach transparency we must maintain a total population of Ntransp ~ Va × 1018 electrons (holes) in the conduction (valence) band of the active region where Va(cm3) is the volume of the active region. The injection current to sustain this population is approximately
University of Birmingham Thermal management performances of PCM/water cooling-plate using for lithium-ion battery module based on non-uniform internal heat source

In order to improve the working performance of the lithium-ion battery, the battery module with Phase change material/water cooling-plate was designed and numerically analyzed based on the energy conservation and fluid dynamics. The non-uniform internal heat source based on 2D electro-thermal model for battery LiFePO4/C was used to simulate the heat generation of each battery. Then factors such as height of water cooling-plate, space between adjacent batteries, inlet mass flow rate, flow direction, thermal conductivity and melting point of PCM were discussed to research their influences on the cooling performance of module. And the 5 continuous charge-discharge cycles was used to research the effect of PCM/water cooling plate on preventing thermal runaway. The results showed that the water cooling plate set close to the near-electrode area of battery removed the majority of heat generated during discharging and decreased the maximum temperature efficiently. The PCM between the adjacent batteries could improve the uniformity of temperature field. In addition, the PCM/water cooling plate could limit the maximum temperature effectively and improve the uniformity of temperature field during the 5 continuous charge-discharge cycles. As a result, it prevented the emergence of thermal runaway and increased the safety of module.
STANDARDIZATION ON FLORAL DESIGN AT CN FLOWER

Recently, floral design and decorations have been closely related in our lives. However, how a floral design firm adopts an appropriate strategy to strengthen its competitive advantage in a highly competitive market environment is an issue that needs urgent exploration. This paper aims to conduct a case study on a successful floral design firm, CN Flower (hereafter CN), which has the highest sales volume in Taiwan. Why and how the CN floral design could be successfully achieved is the focus of this study. By adopting customized standardization as a service mode, the study found that CN can not only satisfy the needs of the customer, but also offer direct benefits for the company. Thus, the results of this study may help to uncover the possible benefits of adopting the customized standardization as a feasible service design strategy.
t-SNAREs and trigger exocytosis

eal-time voltammetry measurements from cracked PC12 cells were used to analyze the role of synaptotagmin–SNARE interactions during Ca 2 -triggered exocytosis. The isolated C2A domain of synaptotagmin I neither binds SNAREs nor inhibits norepinephrine secretion. In contrast, two C2 domains in tandem (either C2A-C2B or C2A-C2A) bind strongly to SNAREs, displace native synaptotagmin from SNARE complexes, and rapidly inhibit exocytosis. The tandem C2 domains of synaptotagmin cooperate via a novel mechanism in which the disruptive R effects of Ca 2 ligand mutations in one C2 domain can be partially alleviated by the presence of an adjacent C2 domain. Complete disruption of Ca 2 -triggered membrane and target membrane SNARE interactions required simultaneous neutralization of Ca 2 ligands in both C2 domains of the protein. We conclude that synaptotagmin–SNARE interactions regulate membrane fusion and that cooperation between synaptotagmin’s C2 domains is crucial to its function.
3 - Estimation des paramètres dans les chaînes de Markov cachées et segmentation d'images

Notre etude traite de l'estimation des parametres dans les chaines de Markov cachees et de la segmentation statistique non supervisee d'images. Nous proposons deux algorithmes originaux d'estimation obtenus a partir des methodes Iterative Conditional Estimation (ICE) et Stochastic Expectation Maximisation (SEM), notes MICE et MSEM respectivement, et montrons leur competitivite vis-a-vis de l'algorithme Expectation Maximisation (EM) dans differents cas d'homogeneite et de bruitage des chaines. L'etude du comportement des trois algorithmes de restauration non supervisee des chaines obtenus par l'adjonction a la methode Mode de la Marginale a Posteriori (MPM) des algorithmes EM, MICE, MSEM respectivement est ensuite proposee. La transformation des processus bidimentionnels en processus mono-dimentionnels par le parcours de Peano rend possible l'application de ces algorithmes au probleme de la segmentation statistique non supervisee d'images. On obtient ainsi des methodes plus rapides que celles utilisant des modelisations par champs de Markov caches et nous montrons que la perte de l'efficacite est, en general, acceptable. La souplesse de notre modelisation permet par ailleurs la conception de nombreux algorithmes de segmentation statistique non supervisee spatio-temporelle d'images. Nous en proposons trois et presentons les resultats de leur application a la segmentation d'une sequence d'images reelles.
Pattern Matching in Column-Strict Fillings of Rectangular Arrays

We study the theory of pattern matching in Fn,k, the set of column strict fillings of k x n rectangular arrays with the integers 1, . , kn. We focus on finding the generating function for the number of consecutive occurrences in elements of Fn,k, of a pattern, T , where T is a standard tableau of shape jk. We show that the generating function for the number of consecutive occurrences of a standard tableau, T , of shape jk , where T has the minimal overlapping property, i.e. any two consecutive occurrences of T in an element, F in Fn,k, can overlap in exactly one column, can be expressed in terms of the number of maximum packings of T that are elements G in Fn (j - 1) + 1,k which have consecutive occurrences of T starting at positions 1, (j - 1) + 1, 2 (j - 1) + 1, . (n - 1) (j -1) + 1. When j = 2, our generating functions can be viewed as generalizations of the generating function for the number of rises in a permutation. When j > 2, our generating functions are generalizations of the generating functions for the number of consecutive occurrences of minimal overlapping permutations in permutations due to Duane and Remmel. We also find generalizations of Andre's results on the generating functions for the number of up-down permutations in terms of maximum packings. We develop several methods for computing the number of maximum packings, G in Fn (j -1) + 1,k, for T , for certain classes of standard tableaux, T , of shape jk. In particular, we completely classify the standard tableaux, T , of shape jk , that have the minimal overlapping property and are such that there is precisely one maximum packing, G in Fn (j -1) + 1,k, for T , for any n >1
The intra‐arterial selective cooling infusion system: A mathematical temperature analysis and in vitro experiments for acute ischemic stroke therapy

The neuroprotection of acute ischemic stroke patients can be achieved by intra‐arterial selective cooling infusion using cold saline, which can decrease brain temperature without influencing the body core temperature. This approach can lead to high burdens on the heart and decreased hematocrit in the scenario of loading a high amount of liquid for longtime usage. Therefore, autologous blood is utilized as perfusate to circumvent those side effects.
Functional genomics of reproduction in pigs: Are we there yet?

Reproductive failure is the main reason for culling females in swine herds and is both a financial and sustainability issue. Because reproductive traits are complex and lowly to moderately heritable, genomic selection within populations can achieve substantial genetic gain in reproductive efficiency. A better understanding of the physiological components affecting the expression of these traits will facilitate greater understanding of the genes affecting reproductive traits and is necessary to improve and optimize management strategies to maximize reproductive success of gilts and sows. Large‐scale genotyping with single‐nucleotide polymorphism (SNP) arrays are used for genome‐wide association studies (GWAS) and have facilitated identification of positional candidate genes. Transcriptomic data can be used to weight SNP for GWAS and could lead to previously unidentified candidate genes. Resequencing and fine mapping of candidate genes are necessary to identify putative functional variants and some of these have been incorporated into new genotyping arrays. Sequence imputation and genotype by sequence are newer strategies that could reveal novel functional mutations. In this study, these approaches are discussed. Advantages and limitations are highlighted where additional research is needed.
Depth-profile of impairments in endothelin-1 – induced focal cortical ischemia

The development of ischemic lesions has primarily been studied in horizontal cortical space. However, how ischemic lesions develop through the cortical depth remains largely unknown. We explored this question using direct current coupled recordings at different cortical depths using linear arrays of iridium electrodes in the focal epipial endothelin-1 (ET1) ischemia model in the rat barrel cortex. ET1-induced impairments were characterized by a vertical gradient with (i) rapid suppression of the spontaneous activity in the superficial cortical layers at the onset of ischemia, (ii) compartmentalization of spreading depolarizations (SDs) to the deep layers during progression of ischemia, and (iii) deeper suppression of activity and larger histological lesion size in superficial cortical layers. The level of impairments correlated strongly with the rate of spontaneous activity suppression, the rate of SD onset after ET1 application, and the amplitude of giant negative ultraslow potentials (∼−70 mV), which developed during ET1 application and were similar to the tent-shaped ultraslow potentials observed during focal ischemia in the human cortex. Thus, in the epipial ET1 ischemia model, ischemic lesions develop progressively from the surface to the cortical depth, and early changes in electrical activity at the onset of ET1-induced ischemia reliably predict the severity of ischemic damage.
Hyperlipidemia in Children and Adolescents

While coronary artery disease (CAD) is thought to be a disease of adulthood, atherosclerosis can originate in childhood and adolescence. There is a paucity of randomized controlled treatment trials regarding dyslipidemia among the younger population. However, it is apparent that childhood dyslipidemia is associated with an earlier onset of CAD. Most recent guidelines by the American College of Cardiology (ACC) and American Heart Association (AHA) focus on lifestyle modification and lifetime risk of atherosclerotic disease, as well as adequate screening measures. Genetic factors, environmental contributors such as pollution, obesity linked to poor nutrition, and sedentary lifestyles are shown to be associated with increased lipid levels and early CAD among children and adolescents. Familial hyperlipidemia is one of the most prevalent genetic diseases and can affect 1 in 250 individuals. A multimodal treatment plan is most effective for children and adolescents with dyslipidemia including lifestyle changes (a modified diet and moderate physical activity) and pharmacologic intervention. The mainstay of pharmacologic treatment for childhood dyslipidemia is similar to that of adults. Statins are the most widely used medications. Newer medications have proven integral in treatment for genetic dyslipidemias including evolocumab and evinacumab.
Early juvenile but not mid-to-late prenatal nutrition controls puberty in heifers but neither impact adult reproductive function

Abstract Objectives were to test the hypothesis that pre- and post-natal nutrition in the bovine female, independently or interactively, affect age at puberty and functional characteristics of the estrous cycle of sexually mature offspring. Brangus and Braford (n = 97) beef cows bearing a female fetus were fed to achieve body condition scores of 7.5–8 (H, obese), 5.5–6 (M, moderate), or 3–3.5 (L, thin) by the start of the third trimester and maintained until parturition. Heifer offspring were weaned and fed to gain weight at either a high (H; 1 kg/day) or a low (L; 0.5 kg/day) rate between 4 and 8 months of age, then fed the same diet during a common feeding period until puberty, which resulted in compensatory growth of heifers in the L group. Heifers (n = 95) from the H postnatal diet reached puberty 2 months earlier (12 ± 0.4 months; P = 0.0002) than those from the L postnatal diet (14 ± 0.4 months). Estrous cycles of a subgroup of postpubertal heifers (n = 53) were synchronized to evaluate antral follicle count (AFC), rate of growth and size of the pre-ovulatory follicle, size of corpus luteum and ovary, endometrial thickness, and plasma concentrations of progesterone and estradiol-17β (E2). Although there was a trend for postnatal H heifers to have greater AFC and plasma concentrations of E2 compared to L heifers, neither pre- nor post-natal nutrition affected any other physiological or hormonal variables, including short-term fertility. Postnatal nutritional effects on pubertal age remained the dominant observed feature. Summary Sentence Age at puberty was advanced in heifers exposed to a high rate of body weight gain during the juvenile period, however neither pre- nor post-natal nutrition affected any other physiological or hormonal variables, including short-term fertility.
miR‐27 and miR‐124 target AR coregulators in prostate cancer: Bioinformatics and in vitro analysis

The inadequate efficacy of the current treatments for metastatic prostate cancer has directed efforts to the discovery of novel therapies. MicroRNAs (miRNAs) have been considered potential therapeutic agents due to their ability to control gene expression and cellular pathways. The accurate identification of genes and pathways which are targeted by a miRNA is the first step in the therapeutic use of these molecules. In this regard, there are multiple experimental and computational methods to predict and confirm the miRNA‐mRNA relationships. The targeting the androgen receptor (AR) indirectly as the most important mediator of prostate cancer has been posited to both control the disease and prevent resistance to treatment. This study aimed to identify miRNAs targeting AR coregulators. For this purpose, we examined target genes by combining miRNA‐mRNA computational and experimental data from various databases. miR‐27a‐3p and miR‐124 displayed the highest scores and were selected as miRNAs with the potential to target candidate genes. Next, three cell lines of prostate cancer including PC3, LNCAP, and DU145 were transfected with plasmids which were expressed these selected miRNAs. Then, the gene expression and cell cycle analysis were performed. A decrease was observed in cell viability in all three cell lines than the cells transfected with backbone plasmid. Furthermore, the findings indicated that miR‐27a‐3p and miR‐124 led to a significant decrease in the expression of all genes that were studied in PC3 cell line. In addition, miR‐124 caused significant the cellular arrest in the G0/G1 stage, while for miR‐27a‐3p, this arrest occurred was in the G2/M stage. Our results indicated that the function of a unique miRNA could be different in different cell lines with particular cancer phenotype based on the cell line stage. These findings offer the possibility of employing the miR‐124 and miR‐27a‐3p as therapeutic agents for prostate cancer treatment.
Epidemiology and outcomes of hypertensive crisis in patients with chronic kidney disease: a nationwide analysis

Background: The epidemiology and outcomes of hypertensive crisis (HTN-C) in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have not been well studied. The objective of our study is to describe the incidence, clinical characteristics, and outcomes of emergency department (ED) visits for HTN-C in patients with CKD and ESRD. Methods: We performed a secondary analysis of Nationwide Emergency Department Sample databases for years 2016–2018 by identifying adult patients presenting to ED with hypertension related conditions as primary diagnosis using appropriate diagnosis codes. Results: There were 348 million adult ED visits during the study period. Of these, 680 333 (0.2%) ED visits were for HTN-C. Out of these, majority were in patients without renal dysfunction (82%), with 11.4 and 6.6% were in patients with CKD and ESRD, respectively. The CKD and ESRD groups had significantly higher percentages of hypertensive emergency (HTN-E) presentation than in the No-CKD group (38.9, 34.2 and 22.4%, respectively; P < 0.001). ED visits for HTN-C frequently resulted in hospital admission and these were significantly higher in patients with CKD and ESRD than in No-CKD (78.3 vs. 72.6 vs. 44.7%; P < 0.0001). In-hospital mortality was overall low but was higher in CKD and ESRD than in No-CKD group (0.3 vs. 0.2 vs. 0.1%; P < 0.0001), as was cost of care (USD 28 534, USD 29 465 and USD 26 394, respectively; P < 0.001). Conclusion: HTN-C constitutes a significant burden on patients with CKD and ESRD compared with those without CKD with a higher proportion of ED visits, incidence of HTN-E, hospitalization rate, in-hospital mortality and cost of care. Graphical abstract: http://links.lww. com/HJH/C22
First Record of Brachymeria podagrica (Hymenoptera: Chalcididae) in Bisha City, Asir Region, Saudi Arabia

Abstract Chalcid Brachymeria podagrica (Fabricius), formerly known as Brachymeria fonscolombei (Dufour), is a parasitoid wasp that infests dipteran larvae of fly, Sarcophaga dux (Thomson), (Diptera: Sarcophagidae) recovered from the dead body of sheep in Bisha City, Asir region–Saudi Arabia. S. dux larvae were infested by B. podagrica. The first instar larvae and pupae of B. podagrica were found inside the larvae and pupae of S. dux. The adults of the parasitic wasp emerged from the pupae of the host. Adults and larvae of the parasitoid wasp were observed under a dissecting microscope. Identification was made by following the identification keys. It was confirmed that it was B. podagrica, which is herewith reported for the first time in Saudi Arabia.