Miracle-dz/UniFAR-FTUs huggingface dataset:
CORRELATION OF PAP SMEAR AND COLPOSCOPY IN RELATION TO BIOPSY FINDINGS IN DETECTION OF PREMALIGNANT LESIONS OF CERVIX IN A TERTIARY CARE CENTRE

Cervical malignancy is a common, preventable and curable cause of morbidity and mortality in our developing nation. Pap smear is the most common used screening test for cervical lesions worldwide. Colposcopy guided biopsy has been defined to be the gold standard method in diagnosing precancerous lesions of the cervix & used in evaluation and management of cervical lesions. Objective: Correlation of papanicolaou (PAP) smear and colposcopy in the detection of premalignant lesions of cervix. Materials and Methods: A prospective observational study was conducted in a tertiary care referral institute in 200 symptomatic women of 30-70 years. PAP smears were performed by the conventional method and colposcopy was done for all 200 women who came with complaints of white discharge per vagina, intermenstrual, or postcoital bleeding, etc. Final correlation of the PAP smear and colposcopy were based on biopsy reports. Results: 58.06% of the subjects who showed positive pap smear and 78.43% who showed positive colposcopy findings also gave positive biopsy findings. It can be deduced that colposcopy is more sensitive(58.06%) while Pap smear is more specific in accurate diagnosis of CIN. Diagnostic accuracy of colposcopy guided biopsy is 35.36%. Conclusion : It is evident that colposcopy is definitely more sensitive and accurate than pap smear. By combining pap smear with colposcopy, we can maximize the sensitivity and specificity of cancer cervix screening.
(2011) Modelling electricity consumption in office buildings: an agent based approach. Energy and Buildings, 43 (10).

In this paper, we develop an agent-based model which integrates four important elements, i.e. organi- sational energy management policies/regulations, energy management technologies, electric appliances and equipment, and human behaviour, to simulate the electricity consumption in ofﬁce buildings. Based on a case study, we use this model to test the effectiveness of different electricity management strategies, and solve practical ofﬁce electricity consumption problems. This paper theoretically contributes to an integration of the four elements involved in the complex organisational issue of ofﬁce electricity consumption, and practically contributes to an application of an agent-based approach for ofﬁce building electricity consumption study.
Allocation and Control of Computing Resources for Real-time Virtual Network Functions

—Upcoming 5G mobile networks strongly rely on Software-Deﬁned Networking and Network Function Virtualization that allow exploiting the ﬂexibility in resource allocation provided by the underlying virtualized infrastructures. These paradigms often employ platform abstractions designed for cloud applications which have not to deal with the stringent timing constraints characterizing virtualized network functions. On the other hand, various techniques exist to provide advanced, predictable scheduling of multiple run-time environments, e.g., containers, within virtualized hosts. In order to let high-level resource management layers take advantage of these techniques, this paper proposes to extend network service descriptors and the Virtualization Infrastructure Manager. This enables Network Function Virtualization orchestrators to deploy components exploiting real-time processor scheduling at the hypervisor or host OS level, for enhanced stability of the provided performance.
A Meta-Analysis of the E ﬀ ects of Slow-Release Urea Supplementation on the Performance of Beef Cattle

Simple Summary: Plant-based feedstu ﬀ s, such as soybean meal and rapeseed meal are utilised to supply rumen degradable protein (RDP) and rumen undegradable protein (RUP) in the diets of ruminant animals (e.g., cattle, bu ﬀ alo, sheep and goat). The RDP is utilised by rumen microbes for microbial protein synthesis. Microbial protein can contribute up to 80% of the protein requirement of ruminants. However, the use of plant protein sources in ruminant diets can be restricted based on their availability, costs and associated environmental impacts. Slow-release urea (SRU) is a non-protein nitrogen (NPN) source that allows for a partial replacement of vegetable RDP sources in ruminant diets by providing a sustained availability of ammonia for rumen microbial synthesis. Over the past three decades, extensive research has been conducted on the use of SRU in beef cattle diets. The current study analysed a combined dataset obtained from multiple research studies to derive quantitative and research-based evidence on the impact of a commercial SRU (Optigen ® ) on beef cattle performance. Results revealed that dietary supplementation of SRU improves the performance, proﬁtability and environmental impacts of beef cattle production. Thus, this study demonstrates SRU as an e ﬀ ective NPN solution in beef cattle diets. Abstract: Slow-release urea (SRU) is a coated non-protein nitrogen (NPN) source for ruminant nutrition. This study applied a meta-analytic technique to quantify the e ﬀ ect of a commercial SRU (Optigen ® , Alltech Inc., Nicholasville, KY, USA) on the performance of beef cattle. Data were extracted from 17 experiments and analysed using the random-e ﬀ ects model to estimate the e ﬀ ect size of SRU on dry matter intake (DMI), crude protein intake (CPI), live weight gain (LWG) and feed e ﬃ ciency (FE) of growing and ﬁnishing beef cattle. There was no e ﬀ ect of feeding SRU on the overall DMI and CPI of beef cattle. Dietary inclusion of SRU improved the overall LWG ( + 92 g / d / head) and FE ( + 12 g LWG / kg DMI / head) of beef cattle. Notably, SRU supplementation in growing cattle exhibited a better improvement on LWG (130 vs. 60 g / d / head) and FE (18 vs. 8 g LWG / kg DMI / head) compared with ﬁnishing cattle. Moreover, SRU showed consistent improvements on the LWG and FE of beef cattle under several study factors. Simulation analysis indicated that positive e ﬀ ects of SRU on LWG and FE improved proﬁtability through reduction in feed cost and reduced the emission intensity of beef production. These results indicate that SRU is a sustainable NPN solution in beef cattle production.
On the Evolvability of Code Generation Patterns: The Case of the Normalized Systems Workﬂow Element

—Normalized Systems Theory (NST) aims to create software systems exhibiting a proven degree of evolvability. The theory contains a set of formally proven theorems and proposes a set of elements (patterns) to realize the adherence to the theorems in practice. While the development and evolution of several information systems in practice (based on the theory) have been documented, the evolution or enhancement regarding one of the fundamental element patterns has not yet been presented. Therefore, this paper discusses the evolution of one of these patterns, the ﬂow element, and what this means for the software applications it is used in. This way, additional insight is provided on how the theory enables the enhancement and simultaneous evolution of large sets of information systems.
The influence of care interventions on the continuity of sleep of intensive care unit patients1

Objective: to identify care interventions, performed by the health team, and their influence on the continuity of sleep of patients hospitalized in the Intensive Care Unit. Method: descriptive study with a sample of 12 patients. A filming technique was used for the data collection. The awakenings from sleep were measured using the actigraphy method. The analysis of the data was descriptive, processed using the Statistical Package for the Social Sciences software. Results: 529 care interventions were identified, grouped into 28 different types, of which 12 (42.8%) caused awakening from sleep for the patients. A mean of 44.1 interventions/patient/day was observed, with 1.8 interventions/patient/hour. The administration of oral medicine and food were the interventions that caused higher frequencies of awakenings in the patients. Conclusion: it was identified that the health care interventions can harm the sleep of ICU patients. It is recommended that health professionals rethink the planning of interventions according to the individual demand of the patients, with the diversification of schedules and introduction of new practices to improve the quality of sleep of Intensive Care Unit patients.
Pozo et al.  Hunting Effects on Red Deer Antler Size 9 Modeling the Impact of Selective Harvesting on Red Deer

22 ABSTRACT Hunting is a common component in the management of ungulate 2012) from the Isle of Rum National Nature Reserve, Scotland, we assessed the relationship 27 between antler length and key demographic processes (i.e., survival, recruitment, antler 28 growth, parent-offspring trait correlation) for the male component of the population. We then constructed the first integral projection model for this species to examine the effects of 30 simulated trophy hunting on 2 population-level parameters: the stable antler size distribution 31 and the relative reproductive value of males. When male mortality rates due to hunting were 32 <20% the effect on antler size distribution and the reproductive value function were relatively 33 small. However, as mortality due to hunting increased to 50% in large individuals, the direct 34 effects of hunting on mean antler size and reproductive value became evident. Our model acts 35 as a useful starting point to investigate the ecological and evolutionary consequences of 36 hunting in red deer.
Inhibition of 20a-Hydroxysteroid Dehydrogenase Activity by Follicle-stimulating Hormone and Androgens in Cultured Rat Granulosa Cells: A Search for the Mechanism of Action1

Alterations of progesterone metabolism and especially of 20a-hydroxysteroid dehydrogenase (20a-HSD) activity were studied in cultured rat granulosa cells following various treatments. The cells were incubated for up to 48 h with or without follicle-stimulating hormone (FSH), androgens, hydroxyflutamide, estrogens, cholera toxin, and dibutyryl cAMP [Bu2 cAMP). Subsequently, the cells were incubated for 3 h with l4(cid:1)14 Cl progesterone (0.5 MM). The progesterone utilization and accumulation of 2O(cid:1)-reduced and 5o-reduced metabolites were assessed following thin-layer chromatography separation of radiolabeled steroids. Both FSH (1 Mg/mI) and testosterone (0.5 MM) decreased the 206-HSD activity by decreasing the maximal velocity (by 52% and 37%, respectively) without changing significantly the Km value. The inhibition of 20o-HSD was demonstrable following 12 and 24 h exposure to FSH and following 24 and 48 h exposure to testosterone. Effects comparable to that induced by testosterone were elicited by other androgens (androstenedione and 5a-dihydrotestosterone), but not by estrogens (estradiol-17(cid:1) and estrone). Hydroxyflutamide reversed testosterone-induced effects: the increase of endogenous progesterone accumulation and the decrease of 20o-HSD activity. Both cholera toxin (0.001-10 Mg/rnl) and Bu2cAMP (62.5-1000 ug/mI) caused a dose-dependent inhibition of 20a-HSD activity. Present results indicate that: action on 20a-HSD
Thermal analysis of PDMS light bulbs with a luminophore

W artykule analizuje sie lampy wykonane z polydimethylsiloxanu PDMS z luminoforem YAG. W lampach tych mozna osiągnąc bialą barwe dzieki odpowiedniej kombinacji materialu. Dzieki odpowiedzniej konstrukcji lampy te mozna uzywac w środowiskach niebezpiecznych jak kopalnie. W artykule analizowano temperature I barwe światla dla roznych luminoforow.
CONSTRUCTING THE K(cid:127)AHLER AND THE SYMPLECTIC STRUCTURES FROM CERTAIN SPINORS ON 4-MANIFOLDS

We show that, on an oriented Riemannian 4-manifold, existence of a non-zero parallel spinor with respect to a spin c structure implies that the underlying smooth manifold admits a K(cid:127)ahler structure. A similar but weaker condition is obtained for the 4-manifold to admit a symplectic structure. We also show that the spin c structure in which the non-zero parallel spinor lives is equivalent to the canonical spin c structure associated to the K(cid:127)ahler structure.
Advanced Research in Computer

-Many organizations are showing their interest in storing data on public clouds. In the last few years, the growth of the data is remarkable. So, the security issues are also associated with storage of data over cloud. This is a major demoralizing factor for probable adopters of the cloud. Hence, cryptographic methods are used that will offer confidentiality and Homomorphic encryption is one of the cryptographic methods that is used in the cloud applications. The objective is to compare the new framework with other previous approaches by using this approach an organization can store its confidential data on the cloud with high security. The new framework is easy to use and does not depend upon security measures taken by the end users. It handles all the cryptographic operations within the trusted infrastructure of the organization then sends the encrypted data to the cloud. The public clouds have not the ability to decrypt the encrypted data that is stored in the cloud. It handles file uploads in an effective manner to reduce the time for uploading the large encrypted files. The objective is to protect and manage the data from the untrusted parties. The proposed paper addresses the confidentiality and produces encrypted storage with the public clouds. This proposed approach uses EcElGamal Homomorphic encryption for storing the user data and uses an updation method for modified file to reduce the time while the transmission of large encrypted files.
RAPID COMMUNICATION POSTOPERATIVE ORAL GLUCOSE TOLERANCE AND STIMULATED INSULIN SECRETION: A PREDICTOR OF ENDOCRINE GRAFT FUNCTION MORE THAN 10 YEARS AFTER PANCREAS-KIDNEY TRANSPLANTATION

Background. After pancreas transplantation, endo- crine function is determined by the insulin secretory capacity of the transplanted pancreas. The authors evaluated the predictive value of postoperative oral glucose tolerance test (OGTT) and stimulated insulin secretion on long-term endocrine function. Methods. Forty-one patients after pancreas-kidney transplantation with systemic venous drainage were studied. Patients were categorized to have normal glu- cose tolerance (NGT) or impaired glucose tolerance (IGT)
toxin-antitoxin systems cooperate to induce persistence.

systems provides the potentialforbistability,andourresultsshow thatevenwhentheydonot exhibit bistabilityalone,unrelatedsystems canbecoupled bythegrowthratetocreatea strongly bistable, hysteretic switch between normal (fast-growing) and persistent (slow-growing) states. Different combinations of kinetic parameters can produce similar toxic switching thresholds, and the proximity of the thresholds is the primary determinant of bistability. Stochastic fluctuations can spontaneously switch all of the toxin–antitoxin systems in a cell at once. The spontaneous switch creates a heterogeneous population of growing and non-growing cells, typical of persisters, that exist under normal conditions, rather than only as an induced response. The frequency of persisters in the population can be tuned for a particular environmental niche by mixing and matching unrelated systems via mutation, horizontal gene transfer and selection.
DEVELOPMENT AND DISEASE Epithelial cell cycling predicts p53 responsiveness to g -irradiation during post-natal mammary gland development

be mediated indirectly by the mitogenic actions of steroid hormones in vivo. 2 ml of medium. medium of serum-free DMEM/F12 buffered with Hepes and NaHCO 3 , plus insulin (5 m g/ml; GibcoBRL Life Technologies, Grand Island, NY). Hormone-supplemented medium prepared by adding 1 ng/ml 17- b -estradiol (Sigma) and 1 m g/ml progesterone (Sigma) to control medium. Growth factor (GF)-supplemented medium was prepared by adding 20 ng/ml each of EGF (Sigma) and TGF a (R&D Systems, Minneapolis, MN) to control medium. Whole organ cultures (WOCs) maintained for 96 hours in 5% CO 2 in air, with daily media changes. After 96 hours, WOCs were subjected to 5 Gy of g -radiation, using a 137 Cs irradiator, while control WOCs were sham irradiated. Six hours after g -irradiation, all WOCs were ﬁxed in 10% PBF overnight, rinsed in 70% ethanol and paraffin- embedded.
Review Ethylene † and fruit softening

This review is concerned with the mechanisms controlling fruit softening. Master genetic regulators switch on the ripening programme and the regulatory pathway branches downstream, with separate controls for distinct quality attributes such as colour, flavour, texture, and aroma. Ethylene plays a critical role as a ripening hormone and is implicated in controlling different facets of ripening, including texture change, acting through a range of transcriptional regulators, and this signalling can be blocked using 1-methylcyclopropene. A battery of at least seven cell-wall-modifying enzymes, most of which are synthesized de novo during ripening, cause major alterations in the structure and composition of the cell wall components and contribute to the softening process. Significant differences between fruits may be related to the precise structure and composition of their cell walls and the enzymes recruited to the ripening programme during evolution. Attempts to slow texture change and reduce fruit spoilage by delaying the entire ripening process can often affect negatively other aspects of quality, and low temperatures, in particular, can have deleterious effects on texture change. Gene silencing has been used to probe the function of individual genes involved in different aspects of ripening, including colour, flavour, ethylene synthesis, and particularly texture change. The picture that emerges is that softening is a multi-genic trait, with some genes making a more important contribution than others. In future, it may be possible to control texture genetically to produce fruits more suitable for our needs.
Conventional and unconventional ubiquitination in plant immunity Conventional and unconventional ubiquitination in plant immunity

SUMMARY Ubiquitination is one of the most abundant types of protein posttranslational modification (PTM) in plant cells. The importance of ubiquitination in the regulation of many aspects of plant immunity has been increasingly appreciated in recent years. Most of the studies linking ubiquitination to the plant immune system, however, have been focused on the E3 ubiquitin ligases and the conventional ubiquitination that leads to the degradation of the substrate proteins by the 26S proteasome. By contrast, our knowledge about the role of unconventional ubiquitination that often serves as non-degradative, regulatory signal remains a significant gap. We discuss, in this review, the recent advances in our understanding of ubiquitination in the modulation of plant immunity, with a particular focus on the E3 ubiquitin ligases. We approach the topic from a perspective of two broadly defined types of ubiquitination in an attempt to highlight the importance, yet current scarcity, in our knowledge about the regulation of plant immunity by unconventional ubiquitination. degradation by the 26S proteasome or a non-proteolytic process. Deubiquitination enzymes (DUBs) can catalyse the removal of ubiquitin from the conjugated substrates and also generate recycled ubiquitin molecules after the ubiquitinated substrates have been degraded. leading to the degradation of the effector to promote host immunity. In addition, APIP6 ubiquitinates the negative immunity regulator OsELF3-2 to promote PTI, and APIP10 functions as a negative regulator of the R protein Piz-t-mediated effector-triggered immunity (ETI). Two other bacterial effectors, AvrptoB and XopL, exhibit C-terminal ubiquitin ligase activity. AvrPtoB ubiquitinates the receptor proteins FLS2 and CERK1, as well as the protein kinase Fen, for degradation to suppress PTI and ETI, respectively. XopL specifically interacts with plant ubiquitin E2 enzymes, AtUBC28 and AtUBC11, to mediate the formation of predominantly K11-linked polyubiquitin chains to target as yet unknown substrate(s). In the regulation of plant immunity by unconventional ubiquitination, K63-linked ubiquitination has been shown to be involved in Fen-mediated immunity. However, it is unknown at present how FNI3/SUV-directed K63-linked ubiquitination regulates Fen-mediated immunity. K63-linked polyubiquitination also functions as a dual targeting signal for BRI1 internalization and sorting along the endocytic pathway to remove the suppression effect of PTI by brassinosteroid (BR) signalling. The Arabidopsis ubiquitin E2 AtUBC1/AtUBC2 and RING-type E3 ligases HUB1/HUB2 together mediate the monoubiquitination of histone H2B to tune plant immunity through an effect on the expression of plant immunity-associated genes. BIK1, botrytis-induced kinase 1; BSK1, BR-signalling kinase 1; BSU1, BRI1 suppressor protein 1; CDG1, constitutive differential growth 1; CERK1, chitin elicitor receptor kinase 1; TGN/EE, trans-Golgi network and early endosome; Ub, ubiquitin.
An Accurate Method for Delay Margin Computation for Power System Stability

The application of the phasor measurement units and the wide expansion of the wide area measurement units make the time delay inevitable in power systems. The time delay could result in poor system performance or at worst lead to system instability. Therefore, it is important to determine the maximum time delay margin required for the system stability. In this paper, we present a new method for determining the delay margin in the power system. The method is based on the analysis in the s-domain. The transcendental time delay characteristics equation is transformed to a frequency dependent equation. The spectral radius is used to find the frequencies at which the roots cross the imaginary axis. The crossing frequencies are determined through the sweeping test and the binary iteration algorithm. A single machine infinite bus system equipped with automatic voltage regulator and power system stabilizer is chosen as a case study. The delay margin is calculated for different values of the power system stabilizer (PSS) gain, and it is found that increasing the PSS gain decreases the delay margin. The effectiveness of the proposed method has been proved through comparing it with the most recent published methods. The method shows its merit with less conservativeness and fewer computations.
tensor analysis improved genetic algorithm for online bin packing. In: Genetic and Evolutionary Computation

Mutation in a Genetic Algorithm is the key variation operator adjusting the genetic diversity in a population throughout the evolutionary process. Often, a ﬁxed mutation probability is used to perturb the value of a gene. In this study, we describe a novel data science approach to adaptively generate the mutation probability for each locus. The trail of high quality candidate solutions obtained during the search process is represented as a 3 rd order tensor. Factorizing that tensor captures the common pattern between those solutions, identifying the degree of mutation which is likely to yield improvement at each locus. An online bin packing problem is used as an initial case study to investigate the proposed approach for generating locus dependent mutation probabilities. The empirical results show that the tensor approach improves the performance of a standard Genetic Algorithm on almost all classes of instances, signiﬁcantly.