Miracle-dz/UniFAR-FTUs huggingface dataset:
KARAKTERISASI KOMPREHENSIF NANO PARTIKEL EKSTRAK DAUN SIRSAK

Nanotechnology has revolutionized various fields, including medicine, by offering new opportunities for research and application. This study focuses on the characterization of nanoparticles derived from soursop leaf extract. Nanoparticles were synthesized using chitosan polymer and soursop leaf extract, and their properties were analyzed. The results showed a wide range of particle sizes, with an average size of 210.9 nm and a mode of 161.4 nm. The nanoparticles exhibited a negative zeta potential of -31.5 mV, indicating their stability in solution. The absorption efficiency was 87.90%, and the drug loading capacity reached 37.92%. Scanning electron microscopy confirmed the spherical morphology of the nanoparticles. These findings highlight the potential of soursop leaf extract nanoparticles for drug delivery and emphasize the importance of their comprehensive characterization for future applications.
Elucidating the Differentiation Synthesis Mechanisms of Differently Colored Resistance Quinoa Seedings Using Metabolite Profiling and Transcriptome Analysis

Quinoa (Chenopodium quinoa wild.), a dicotyledonous plant native to the Andes, is an increasingly popular pseudograin owing to its high nutritional value, stress resistance capabilities, and gluten-free properties. In this study, we aimed to explore the dynamic changes in different varieties of quinoa at the seedling stage and their regulatory networks. Here, we found that the leaves of quinoa showed obvious coloration after 45 days, and four quinoa seedling types (red, white, yellow, and black) were subjected to ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) and transcriptome sequencing to identify their differentially expressed genes and metabolites. A total of 29 differential metabolites and 19 genes (14 structural and 5 regulatory genes) were identified, and consistent differences were observed in the flavonoid, phenolic acid, and alkaloid metabolites in the different quinoa types. These differential metabolites were significantly enriched in flavonoid and flavonol biosynthesis, flavonoid biosynthesis, and phenylpropanoid biosynthesis pathways. In addition, real-time fluorescence quantitative PCR (RT-qPCR) technology was used to detect the expression of four structural genes involved in the flavonoid biosynthesis pathway and four regulatory genes (interaction network). The results revealed that the structural and regulatory gene transcript levels in the flavonoid pathway were higher in the red quinoa cultivars than in the white, yellow, and black. Additionally, the differences in the leaves of these four quinoa cultivars were mainly due to differences in flavonoid, phenolic acid, and alkaloid accumulation. Our findings provide a basis for understanding the accumulation and coloration mechanisms of flavonoids, phenolic acids, and alkaloids in quinoa seedlings of different colors and also provide a theoretical basis for future investigations.
Melatonin Activation by Human Cytochrome P450 Enzymes: A Comparison between Different Isozymes

Cytochrome P450 enzymes in the human body play a pivotal role in both the biosynthesis and the degradation of the hormone melatonin. Melatonin plays a key role in circadian rhythms in the body, but its concentration is also linked to mood fluctuations as well as emotional well-being. In the present study, we present a computational analysis of the binding and activation of melatonin by various P450 isozymes that are known to yield different products and product distributions. In particular, the P450 isozymes 1A1, 1A2, and 1B1 generally react with melatonin to provide dominant aromatic hydroxylation at the C6-position, whereas the P450 2C19 isozyme mostly provides O-demethylation products. To gain insight into the origin of these product distributions of the P450 isozymes, we performed a comprehensive computational study of P450 2C19 isozymes and compared our work with previous studies on alternative isozymes. The work covers molecular mechanics, molecular dynamics and quantum mechanics approaches. Our work highlights major differences in the size and shape of the substrate binding pocket amongst the different P450 isozymes. Consequently, substrate binding and positioning in the active site varies substantially within the P450 isozymes. Thus, in P450 2C19, the substrate is oriented with its methoxy group pointing towards the heme, and therefore reacts favorably through hydrogen atom abstraction, leading to the production of O-demethylation products. On the other hand, the substrate-binding pockets in P450 1A1, 1A2, and 1B1 are tighter, direct the methoxy group away from the heme, and consequently activate an alternative site and lead to aromatic hydroxylation instead.
Next generation enhanced vision system processing

The use of multiple, high sensitivity sensors can be usefully exploited within military airborne enhanced vision systems (EVS) to provide enhanced situational awareness. To realise such benefits, the imagery from the discrete sensors must be accurately combined and enhanced prior to image presentation to the aircrew. Furthermore, great care must be taken to not introduce artefacts or false information through the image processing routines. This paper outlines developments made to a specific system that uses three collocated low light level cameras. As well as seamlessly merging the individual images, sophisticated processing techniques are used to enhance image quality as well as to remove optical and sensor artefacts such as vignetting and CCD charge smear. The techniques have been designed and tested to be robust across a wide range of scenarios and lighting conditions, and the results presented here highlight the increased performance of the new algorithms over standard EVS image processing techniques.
Seismic wave velocity changes and stress build‐up in the crust of the Kanto‐Tokai Region

We show there are large temporal P‐wave velocity changes in the crust of the Kanto‐Tokai region in Japan from repeated observations of explosions. We find that the variation is the response of the crustal rocks to two components of stress change, the tidal stress and the secular stress accumulation. The inferred annual rate of fractional velocity change (Δν/ν/year) caused by the stress accumulation in the upper crust is of the order of 10−3/year. The results indicate that the build‐up of stress in the crust can be monitored by precise observations of seismic wave velocities.
Point Source Nutrient Fluxes from an Urban Coast: the Boynton (Florida) Inlet

The Boynton Inlet (SE Florida, USA) is one of two tidal inlets connecting the Lake Worth Lagoon to the Atlantic Ocean. To quantitate the amount of anthropogenic materials reaching the South Florida coastal ocean and reef track, nutrient fluxes through the Boynton Inlet were measured during two 48-hour intensive studies conducted on June 4-6 and September 26-28, 2007. These studies combined analyses of water samples taken at regular intervals in the Boynton Inlet with acoustic Doppler current profiler (ADCP) measurements of the flow through the inlet. Data collected include concentrations of nutrients (silicate [Si], orthophosphate [PO 4 ], ammonium [NH 4 ], nitrate+nitrite [N+N]), isotope ratios of nitrogen, and physical parameters that included pH, salinity, total suspended solids (TSS), and turbidity. The study found a significant but highly variable flux of nutrients in the eight outgoing (ebb) tidal pulses sampled. Daily fluxes of nitrate+nitrite ranged from 16 to 565 kg N, silicate from 564 to 5197 kg Si, phosphate from 154 to 309 kg P, and ammonium from 34 to 354 kg N. These results are compared with other sources of nutrient inputs into the coastal environment. Inlets are a significant source of offshore nutrients.
Flexible and Ecofriendly Keypad Based on Paper and Pencil

Pencil-on-paper electronics has gained growing interests as cost-effective, ecofriendly, flexible, and light-weight devices for various applications. In this letter, a flexible keypad employing pencil-on-paper capacitive touch sensors is presented. Spiral-type interdigitated sensors are interconnected via steel threads as well as graphite paths to constitute a ten-button keypad. Passivation of the sensors by means of acrylic paint coating works as protection against deterioration from bending, folding, and extended usage. Backing of the keypad with silicone provides extra durability. Sensor reading is administered by Arduino boards. The same manufacturing method is used to scale up the system to a 44-button keyboard. Functionalities of both systems are successfully demonstrated, and effectiveness of the passivation is verified.
Improving OCT Image Segmentation of Retinal Layers by Utilizing a Machine Learning Based Multistage System of Stacked Multiscale Encoders and Decoders

Optical coherence tomography (OCT)-based retinal imagery is often utilized to determine influential factors in patient progression and treatment, for which the retinal layers of the human eye are investigated to assess a patient’s health status and eyesight. In this contribution, we propose a machine learning (ML)-based multistage system of stacked multiscale encoders and decoders for the image segmentation of OCT imagery of the retinal layers to enable the following evaluation regarding the physiological and pathological states. Our proposed system’s results highlight its benefits compared to currently investigated approaches by combining commonly deployed methods from deep learning (DL) while utilizing deep neural networks (DNN). We conclude that by stacking multiple multiscale encoders and decoders, improved scores for the image segmentation task can be achieved. Our retinal-layer-based segmentation results in a final segmentation performance of up to 82.25±0.74% for the Sørensen–Dice coefficient, outperforming the current best single-stage model by 1.55% with a score of 80.70±0.20%, given the evaluated peripapillary OCT data set. Additionally, we provide results on the data sets Duke SD-OCT, Heidelberg, and UMN to illustrate our model’s performance on especially noisy data sets.
Effects of land‐use changes on hydrological processes in the middle basin of the Heihe River, northwest China

The effects of land‐use changes on the runoff process in the midstream plain of this arid inland river basin are a key factor in the rational allocation of water resources to the middle and lower reaches. The question is whether and by how much increasingly heavy land use impacts the hydrological processes in such an arid inland river basin. The catchment of the Heihe River, one of the largest inland rivers in the arid region of northwest China, was chosen to investigate the hydrological responses to land‐use change. Flow duration curves were used to detect trends and variations in runoff between the upper and lower reaches. Relationships among precipitation, upstream runoff, and hydrological variables were identified to distinguish the effects of climatic changes and upstream runoff changes on middle and downstream runoff processes. The quantitative relation between midstream cultivated land use and various parameters of downstream runoff processes were analysed using the four periods of land‐use data since 1956. The Volterra numerical function relation of the hydrological non‐linear system response was utilized to develop a multifactor hydrological response simulation model based on the three factors of precipitation, upstream runoff, and cultivated land area. The results showed that, since 1967, the medium‐ and high‐coverage natural grassland area in the midstream region has decreased by 80·1%, and the downstream runoff has declined by 27·32% due to the continuous expansion of the cultivated land area. The contribution of cultivated land expansion to the impact on the annual total runoff is 14–31%, on the annual, spring and winter base flow it is 44–75%, and on spring and winter discharge it is 23–64%. Once the water conservation plan dominated by land‐use structural adjustments is implemented over the next 5 years, the mean annual discharge in the lower reach could increase by 8·98% and the spring discharge by 26·28%. This will significantly alleviate the imbalance between water supply and demand in both its quantity and temporal distribution in the middle and lower reaches. Copyright © 2006 John Wiley & Sons, Ltd.
Warming of the subpolar Atlantic triggered by freshwater discharge at the continental boundary

The traditional view is that widespread discharge of freshwater into the North Atlantic leads to a reduction of the Atlantic Meridional Overturning Circulation (AMOC), a concomitant reduction of poleward heat transport and a cooling of the climate of the North Atlantic. Here we report upon coupled atmosphere‐ocean general circulation model experiments that suggest a more non‐uniform response of the North Atlantic climate to large freshwater perturbations. We show that in a cold climate with extensive sea ice coverage in the Labrador Sea, a massive discharge of freshwater along coastal boundaries leads to an anomalous warming in the western North Atlantic. The warming persist despite a significant weakening of the AMOC and its associated heat transport. It is maintained by major reorganizations of the large‐scale wind field, oceanic circulation and convection in the subpolar Atlantic.
ANTIBACTERIAL AND ANTIACNE ACTIVITY OF n-HEXANE FRACTION OF ALFALFA HERB (Medicago sativa L.) ETHANOL EXTRACT IN VITRO AND ON RABBIT (Oryctolagus cuniculus)

Propionibacterium acnes (P. acnes) can cause inflammation of the polysebaceous glands and lead to acne. Flavonoids in alfalfa herb are thought to have antibacterial and antiinflammatory properties. Flavonoids can be absorbed into n-hexane solvents. This study aims to determine antibacterial activity of n-hexane fraction of alfalfa herb ethanol extract (nHFAH) against P. acnes in vitro, to calculate the total flavonoid levels in the fraction, and to determine antiacne activity of the fraction on rabbit. This study is an experimental study with post-test control group design. Extraction of alfalfa herb was done by maceration method using 70% ethanol and fractionated with n-hexane. Antibacterial activity test was carried out using disk diffusion with 5 series of concentrations (15%, 20%, 25%, 30% dan 35%), positive control (clindamycin 2 µg/disk) and negative control (DMSO 100%). Diameters of the inhibition area were analyzed statistically using a Kruskal Wallis test followed by Mann Withney test with 95% of confidence level. Rabbit back skin was shaved on 5 different areas (3x3 cm2/area). Induced with 0.2 mL of P. acnes suspension (3x109 CFU/mL) intradermal. Acne formed (24 hours) on all areas, then were treated with T1 (clindamycin 2%), T2 (DMSO 100%), T3 (nHFAH 20%), T4 (nHFAH 25%), T5 (nHFAH 30%). Erythema diameter reduction on day 9 was analyzed using one-way anova, continued by post hoc tukey with 95% of confidence level. Total nHFAH flavonoid levels were tested by colorimetric method using UVVis spectrophotometer at λ 429.5 nm. The results showed that nHFAH has antibacterial activity against P. acnes with an average value of diameter of inhibition area for each concentration were 7.30; 7.49; 7.75; 7.92 and 8.24 mm. nHFAH exhibits antiacne activity with the percentage for each concentration were 67.01%; 77.84% and 85.84% respectively. Total nHFAH flavonoid levels were 6.09 mgQE/ gram.Keywords: Alfafa herb, n-Hexane fraction, Propionibacterium acnes.
Recurrence of the Neuromuscular Blockade after the Sugammadex Administration after Opioid-Induced Respiratory Depression: A Report of 3 Cases

Three elderly patients received sugammadex after confirmation of train-of-four (TOF) stimulation at the end of the surgery. They presented opioid-induced respiratory depression accompanied by severe acidosis postoperatively. Even after the reversal of opioid intoxication with naloxone, the respiration did not recover, and TOF revealed recurrent paralysis. Two of three cases completely recovered after additional sugammadex administration, but remnant 1 case without sugammadex transferred to intensive care unit with intubated status. Even if the recommended dose of sugammadex is administered, there can be recurrent neuromuscular blockade by complicated reasons. Continuous quantitative neuromuscular monitoring may be needed to prevent these unusual situations.
The Roles of Perennial Crop Systems to Rural Households: A Case Study in Dak Lak Province, Central Highlands, Vietnam

This study investigated the role of perennial crop systems in enhancing sustainable livelihoods among rural households in Dak Lak province, Vietnam, with a particular focus on coffee and pepper crops. To gather data for this study, structured interviews were conducted with 86 households (90 farms) through a multi-stage sampling approach from January to May 2019. Moreover, the effectiveness of two agroforestry systems, monoculture and multitrophic agroforestry, was compared. The findings highlighted numerous significant conclusions. First, perennial crop systems contributed significantly to the improvement of rural households' livelihoods through improved monetary income, job creation, the participation of women, and expanded work prospects. Second, intercropping systems were the most economically viable sources of income and less susceptible to market price risk. This conclusions emphasize the importance of farmers and local governments understanding the roles of perennial crops to livelihoods.
A note on the attenuation of surface gravity waves by rainfall

Rainfall has long been associated with damping of short surface gravity waves. A theory is presented which uses a thin rain-induced turbulent surface layer to explain the enhanced attenuation. In the presence of a thin turbulent surface layer, the e-folding attenuation time for the 30-cm wavelength surface gravity waves needed for remote sensing of the ocean surface using synthetic aperture radar (SAR) is reduced from several minutes to several seconds. This explains the observation of low SAR radar return from regions of high rainfall. Longer wavelengths are also affected depending on the strength of the mixing and the thickness of the turbulent layer.
Variations in essential oil compositions and biological activities of Artemisia annua L. (sweet wormwood) at different growth periods

Abstract The current study is purposed to examine the yields, chemical compositions, antioxidant and antimicrobial properties of Artemisia annua L. essential oils obtained at pre-flowering, initial flowering and post-flowering growth stages. The main constituent of the essential oils in pre-flowering stage was camphor (47.88%). At initial flowering, composition of the essential oil changed drastically. Artemisia ketone increased from 4.62% to 55.31% and camphor decreased to 11.50% resulting in an artemisia ketone chemotype essential oil. In post-flowering stage, both camphor and artemisia ketone did not change significantly compared to initial flowering. These changes of the essential oil compositions caused various alterations in antioxidant and antimicrobial activities. Antioxidant and antibacterial activities of the essential oils were slightly increased in parallel with artemisia ketone. On the other hand, the decrease in the camphor content executed a negative impact on antifungal activities. Correlation analysis revealed that artemisia ketone was slightly more antioxidant and more potent antibacterial while camphor was found to be more effective on investigated fungal strains.
Analysis of Rock Abundance on Lunar Surface and Near-Surface Using Mini-RF SAR Data

Polarimetric synthetic aperture radar (SAR) provides an effective way to understand the physical properties of planetary surfaces. Rocks are the products of specific geological events, recording the evolution of impact craters on airless bodies. Multiple-scattered radar echoes from the surface or near-surface rocks generally exhibit high circular polarization ratio (CPR). In this article, we systematically investigate the relationship between radar CPR and rock abundance of lunar regolith using miniature radio frequency (Mini-RF) SAR data. A total of 51 craters with diameters of 11.8–200 km are selected for analysis. The mean values of Mini-RF CPR and Diviner rock abundance are calculated for the interior and exterior of each crater. Statistical results show a close correlation between Mini-RF CPR and Diviner rock abundance, where high radar CPR and Diviner rock abundance are observed at the blocky ejecta. However, we find the difference of mean CPR value between crater interior and exterior is smaller than that of Diviner rock abundance. This may be attributed to the near-surface rocks that contribute to radar CPR but are not considered in the inversion of Diviner rock abundance. Therefore, the concept of volumetric rock abundance is introduced, indicating the proportion of rocks with diameters larger than one-tenth of the radar wavelength within the detection area. A three-component CPR model is then developed to link radar CPR to volumetric rock abundance. Furthermore, an inverse power-law relationship between volumetric rock abundance and crater ages is discovered, which further indicates the feasibility of using SAR data to estimate rock abundance of lunar regolith.
PROSODIC CHARACTERISTICS OF ACOUSTIC SIGNAL IN SERBIAN AND EMOTION RECOGNITION

The study focuses on the process of emotional recognition based on prosodic characteristics of acoustic signal in Serbian. Its main objective is to answer the question of the success of prosodic recognition of several emotions in Serbian. Furthermore, it explores whether the success in recognizing emotions in Serbian varies with regards to the following variables: the type of emotion, gender and the type of sentence. A total of 25 participants of average age around 23 participated in the study. The data was created by using Praat software for speech analysis. The results show general success in recognizing emotions on the level of M=12.43 (SD= 6.11). The participants were the most successful in recognizing the emotion of happiness, and the least successful in recognizing sadness. Post hoc analysis found a statistically significant difference in recognizing happiness and emotions of the negative spectrum (sadness, boredom, anger and fear). The results are discussed from the point of social functions of emotions, as well as the characteristics of the affective prosody in Serbian, with recognition of inevitable methodological limitations.