Miracle-dz/UniFAR-FTUs huggingface dataset:
Özgün Araştırma / Original Investigation

Objective: The present study was designed to investigate the prevalence of thyroid dysfunction in early pregnancy and to compare pregnant women with and without risk factors for thyroid dysfunction. Methods: One hundred and ninety-four women in weeks 6-20 of pregnancy attending the Obstetrics and Gynaecology Clinics of Bakırkoy MD Sadi Konuk Teaching and Research Hospital between April 2008 and February 2009 were included in the study. The cases were separated into two groups, Group I and Group II. Serum levels of antiTPO (anti-thyroid peroxidase), TSH (thyroid stimulating hormone), free T4 (thyroxine) and free T3 (triiodothyronine) were measured in all cases. Results: The prevalence of hypothyroidism, subclinical hypothyroidism and hyperthyroidism was found to be 3.6%, 1% and 1%, respectively. The frequency of abortus was not statistically different between pregnant women with thyroid disease and without thyroid disease. The prevalence of thyroid disease was significantly higher in cases with positive anti-TPO and in cases who underwent surgery. Thyroid diseases which required treatment were diagnosed in five of 128 pregnant women without risk factors for thyroid disease. There was no statistically significant difference in the prevalence of thyroid disease between pregnant women with risk factors and without risk factors. Conclusion: The frequency of thyroid dysfunction was similar in the two groups, including cases with or without risk factors for thyroid disease. In spite of many endocrine societies, we suggest that all pregnant women should be screened without consideration of risk factors to avoid adverse outcomes. (Gazi Med J 2012; 23: 6-9)
The privileged sensing framework: A principled approach to improved human-autonomy integration

ABSTRACT A primary goal for human-autonomy integration (HAI) is to balance the strengths of human and autonomy in order to achieve performance objectives more efficiently and robustly than either the human or autonomous agents would independently. This paper proposes the Privileged Sensing Framework (PSF) as a novel approach to HAI. This approach is based on the concept of dynamically ‘privileging’ information during the process of integration by dynamically bestowing special rights based on the characteristics of each individual agent, the task context, and the performance goals. The proposed framework is tested through a series of simulation experiments that provide a clear demonstration of increased accuracy and throughput of human-autonomy performance. These proof-of-concept simulations provide initial evidence of the utility of the PSF. Continued development of this approach has the potential to revolutionise capabilities of multi-agent cooperative teams across a broad range of applications.
Sustentabilidade e resiliência

O artigo discute os desafios da proteção do patrimônio cultura, em tempo de crise. Começa por explorar questões históricas e filosóficas em relação a monumentos e patrimônio cultural, em seguida a Convenção de Haia – 1954; 1999. Conclui-se por propor que o patrimônio é essencial, nestes tempos e circunstâncias de crise, para criticar atitudes e abordagens sem crítica. O patrimônio pode servir para a convivência e para a aceitação de outras maneiras de pensar e se comportar.
Recalcitrant C Source Mapping Utilizing Solely Terrain-Related Attributes and Data Mining Techniques

Agricultural practices affect arbuscular mycorrhizal fungal (AMF) hyphae growth and glomalin production, which is a recalcitrant carbon (C) source in soil. Since the spatial distribution of glomalin is an interesting issue for agronomists in terms of carbon sequestration, digital maps are a cost-free and useful approach. For this study, a set of 120 soil samples was collected from an experimental area of 310 km2 from the Sarab region of Iran. Soil total glomalin (TG) and easily extractable glomalin (EEG) were determined via ELISA using the monoclonal antibody 32B11. Soil organic carbon (OC) was also measured. The ratios of TG/OC and EEG/OC as the glomalin–C quotes of OC were calculated. A total of 17 terrain-related attributes were also derived from the digital elevation model (DEM) and used as static environmental covariates in digital soil mapping (DSM) using three predictive models, including multiple linear regression (MLR), random forests (RF), and Cubist (CU). The major findings were as follows: (a) DSM facilitated the interpretation of recalcitrant C source variation; (b) RF outperformed MLR and CU as models in predicting and mapping the spatial distribution of glomalin using available covariates; (c) the best accuracy in predictions was for EEG, followed by EEG/OC, TG, and TG/OC.
Hybrid termination metamaterial CRLH resonant antennas: Analysis and design

This paper discusses the properties of hybrid terminated metamaterial CRLH resonant antennas. The antenna proves that the hybrid termination can increase the electrical length of based antennas and hence it can increase the number of possible frequency bands at compact size. This is emphasized through developing a dual band hybrid termination CRLH cell antenna resonating at 2.4 GHz and 5.2 GHz. The antenna design and performance is compared to open/short circuit termination CRLH resonant antennas. All the discussed antennas in this paper have same compact size (21 × 31 mm2). An experimental measurements are carried out for the hybrid terminated CRLH resonant antenna as further validation. The proposed antenna can find possible applications in WiFi/WiMAX services.
Frequency Alteration Built on an Electro-Optical Sampling SOA–MZI Using a Differential Modulation Schema

In this paper, we present a real and simulated study of a frequency up mixing employing an electro-optical sampling semiconductor optical amplifier Mach–Zehnder interferometer (SOA–MZI) along with the differential modulation schema. The sampling signal is generated by an optical pulse clock (OPC) at a frequency of fs= 19.5 GHz. The quadratic phase shift keying (QPSK) signal at an intermediate frequency (IF) fIF is shifted to high frequencies nfs ± fIF at the SOA–MZI output. Using a simulator entitled Virtual Photonics Inc. (VPI), we generate sampled QPSK signals and analyze their merits during conversion gains and error vector magnitudes (EVMs). We conducted simulations of mixing in the SOA–MZI operating in a high-frequency band up to 195.5 GHz. The positive conversion gain is accomplished over the mixing frequencies. The EVM is used to evaluate the performance of the electro-optical sampling up-convertor. The EVM reaches 14% at a data rate of 5 Gbit/s at 195.5 GHz. During the experimental work, the results obtained in simulations are set side by side with the factual ones in the frequency range up to 59 GHz. Thus, the comparison between them confirms that they have approximately the same performance.
Therapeutic Intervention in Cancer by Isoliquiritigenin from Licorice: A Natural Antioxidant and Redox Regulator

Oxidative stress could lead to a variety of body dysfunctions, including neurodegeneration and cancer, which are closely associated with intracellular signal transducers such as reactive oxygen species (ROS). It has been suggested that ROS is the upstream regulator of autophagy, and that it provides a negative feedback regulation to remove oxidative damage. Defects in the ROS-autophagic redox homeostasis could lead to the increased production of ROS and the accumulation of damaged organelles that in turn promote metabolic reprogramming and induce tumorigenesis. One significant characteristic of pancreatic cancer is the reprogramming of cellular energy metabolism, which facilitates the rapid growth, invasiveness, and the survival of cancer cells. Thus, the rectification of metabolic dysfunction is essential in therapeutic cancer targeting. Isoliquiritigenin (ISL) is a chalcone obtained from the plant Glycyrrhiza glabra, which is a powdered root licorice that has been consumed for centuries in different regions of the world. ISL is known to be a natural antioxidant that possesses diversified functions, including redox regulation in cells. This review contains discussions on the herbal source, biological properties, and anticancer potential of ISL. This is the first time that the anticancer activities of ISL in pancreatic cancer has been elucidated, with a coverage of the involvement of antioxidation, metabolic redox regulation, and autophagy in pancreatic cancer development. Furthermore, some remarks on related compounds of the isoflavonoid biosynthetic pathway of ISL will also be discussed.
A Method for In Situ Reverse Genetic Analysis of Proteins Involved mtDNA Replication

The unavailability of tractable reverse genetic analysis approaches represents an obstacle to a better understanding of mitochondrial DNA replication. Here, we used CRISPR-Cas9 mediated gene editing to establish the conditional viability of knockouts in the key proteins involved in mtDNA replication. This observation prompted us to develop a set of tools for reverse genetic analysis in situ, which we called the GeneSwap approach. The technique was validated by identifying 730 amino acid (aa) substitutions in the mature human TFAM that are conditionally permissive for mtDNA replication. We established that HMG domains of TFAM are functionally independent, which opens opportunities for engineering chimeric TFAMs with customized properties for studies on mtDNA replication, mitochondrial transcription, and respiratory chain function. Finally, we present evidence that the HMG2 domain plays the leading role in TFAM species-specificity, thus indicating a potential pathway for TFAM-mtDNA evolutionary co-adaptations.
Does Husband's Education Level Matter to Antenatal Care Visits? A Study on Poor Households in Indonesia

Background: Involvement in antenatal care (ANC) is one of the husband's responsibilities for his wife's health. Objective: This study analyzed the contribution of the husband's education level to his involvement in ANC visits among poor households. Methods: The study employed secondary data from the 2017 Indonesian Demographic and Health Survey. The study analyzed 6429 respondents. The analysis units were poor women aged 15–49 years, had a husband, and had ever been pregnant for the past 5 years. Besides husband's education, other independent variables analyzed were residence, husband's age and occupation, and wife's parity. The analysis used a binary logistic regression test in the final step. Results: Husbands with a primary education record were 1.381 times more likely to participate in ANC visits than those without education. Husbands who had secondary education were 2.339 times more likely to get involved in ANC visits than those without education records. Moreover, husbands who had higher education were 3.376 times more likely to be engaged in ANC visits than those without education records. Conclusions: The study concludes that better education levels will be more likely to motivate husbands to get involved in ANC visits.
Pilot Flying and Pilot Monitoring’s Aircraft State Awareness During Go-Around Execution in Aviation: A Behavioral and Eye Tracking Study

ABSTRACT Objective: Examination of the performance and visual scanning of aircrews during final approach and an unexpected go-around maneuver. Background: Accident and incident analyses have revealed that go-around procedures are often imperfectly performed because of their complexity, their high time stress, and their rarity of occurrence that avails little time for practice. We wished to examine this experimentally and establish the frequency and nature of errors in both flight-performance and visual scanning. Method: We collected flight-performance (e.g., errors in procedures, excessive flight deviations) and eye-tracking data of 12 flight crews who performed final approach and go-around flight phases in realistic full-flight transport-category simulators. Results: The pilot performance results showed that two thirds of the crews committed errors including critical trajectory deviations during go-arounds, a precursor of accidents. Eye-tracking analyses revealed that the cross-checking process was not always efficient in detecting flight-path deviations when they occurred. Ocular data also highlighted different visual strategies between the 2 crew members during the 2 flight phases. Conclusion: This study reveals that the go-around is a challenging maneuver. It demonstrates the advantages of eye tracking and suggests that it is a valuable tool for the explicit training of attention allocation during go-arounds to enhance flight safety.
DRAGONFLY: a UAV Rapidly Deployed Micro-Profiler Array for Underwater Thermocline Observation

Underwater thermocline, common in the lakes and ocean, plays a vital role in meteorological forecasting in the ocean and lakes dynamics research. This letter proposes a method for rapid and multipoint observation of thermocline variations with time and space using an airdropped micro-profiler array, named the DRAGONFLY system. It comprises specially designed disposable low-cost micro-profilers, a general unmanned aerial carrier platform, and a ground control system. This system can conduct periodic profile observations at a single point or quickly survey a large area. A series of experiments to characterize the micro-profiler and the DRAGONFLY system were conducted in Qiandao Lake, China. We demonstrate the developed system with data from field experiments, which show very high flexibility, and feasibility to observe the lake thermocline, implying potential applications in ocean transient phenomena observation.
Estimation of Upper Limb Kinematics with a Magnetometer-Free Egocentric Visual-Inertial System*

Most human activities in daily living or professional work rely on upper body motion. Measuring upper body motion is essential for many applications such as health evaluation, rehabilitation, human power augmentation, skill transferring, etc. Computer vision-based systems have been widely used to directly capture upper limb motion but are usually constrained in a restricted area. Wearable sensors such as inertial measurement units (IMUs) are promising to enable ambulant and out-of-lab measurements but also suffer from issues such as magnetic distortion and drifting. Some visual-inertial systems have been proposed recently to fuse these two complementary measurements but mostly apply in a restricted area. In this paper, we propose a fully wearable egocentric visual-inertial system to estimate the upper-limb pose. Magnetometers are not used to allow the system to work in complex industrial and daily living scenarios or to be integrated with motorized assistive devices. Methods to automatically calibrate the sensor-to-segment alignment and estimate upper body motion is presented and validated with an optical motion capture system. Experimental results showed the system can estimate the joint angles without drift and obtain accurate wrist position even with occlusion, verifying the efficacy of the proposed system and method.
Effective Risk Communication for Android Apps

The android platform adopts permissions to protect sensitive resources from untrusted apps. However, after permissions are granted by users at install time, apps could use these permissions (sensitive resources) with no further restrictions. Thus, recent years have witnessed the explosion of undesirable behaviors in Android apps. An important part in the defense is the accurate analysis of Android apps. However, traditional syscall-based analysis techniques are not well-suited for Android, because they could not capture critical interactions between the application and the Android system. This paper presents VetDroid, a dynamic analysis platform for generally analyzing sensitive behaviors in Android apps from a novel permission use perspective. VetDroid proposes a systematic permission use analysis technique to effectively construct permission use behaviors, i.e., how applications use permissions to access (sensitive) system resources, and how these acquired permission-sensitive resources are further utilized by the application. With permission use behaviors, security analysts can easily examine the internal sensitive behaviors of an app. Using real-world Android malware, we show that VetDroid can clearly reconstruct fine-grained malicious behaviors to ease malware analysis. We further apply VetDroid to 1249 top free apps in Google Play. VetDroid can assist in finding more information leaks than TaintDroid, a state-of-theart technique. In addition, we show how we can use VetDroid to analyze fine-grained causes of information leaks that TaintDroid cannot reveal. Finally, we show that VetDroid can help to identify subtle vulnerabilities in some (top free) applications otherwise hard to detect.
A Detumbling Strategy for an Orbital Manipulator in the Post-Grasp Phase

In this paper, we propose a detumbling strategy that stabilizes the motion of a tumbling client satellite using an orbital servicing manipulator, which is the goal of the post-grasp phase. One of the critical aspects in this phase is ensuring that excessive contact forces are not generated at the grasp interface. In addition, space mission requirements might demand a nominal manipulator configuration that is suitable for further manipulation/servicing activities. The proposed strategy allows the detumbling of the client motion while ensuring that the contact forces developed at the grasp interface do not violate a safety threshold. Further, it allows the reconfiguration of the manipulator arm by exploiting the full actuation capability of the manipulator-equipped servicing spacecraft. The controller guarantees joint task convergence in the nullspace of the manipulator's end-effector, and is also valid for kinematically singular configurations of the manipulator. It is further augmented using a quadratic programming based approach to optimally constrain the contact forces. Finally, simulation results for a post-grasp detumbling scenario are shown to validate the effectiveness of the proposed method.
Development of synchronous housing infrastructure for laborers in industrial zones

Developing synchronous housing infrastructure for workers in industrial zones is an essential factor for the sustainable socio-economic development as well as ensuring life quality and social security, especially in attracting high-quality investment and shifting supply chains into Vietnam in the present stage. This article tackles the theoretical and practical aspects and suggests certain solutions to develop synchronous housing infrastructure for workers in industrial zones in our country as well as in Hung Yen province.
S-Adenosylmethionine Inhibits Colorectal Cancer Cell Migration through Mirna-Mediated Targeting of Notch Signaling Pathway

Metastasis is a leading cause of mortality and poor prognosis in colorectal cancer (CRC). Thus, the identification of new compounds targeting cell migration represents a major clinical challenge. Recent findings evidenced a central role for dysregulated Notch in CRC and a correlation between Notch overexpression and tumor metastasis. MicroRNAs (miRNAs) have been reported to cross-talk with Notch for its regulation. Therefore, restoring underexpressed miRNAs targeting Notch could represent an encouraging therapeutic approach against CRC. In this context, S-adenosyl-L-methionine (AdoMet), the universal biological methyl donor, being able to modulate the expression of oncogenic miRNAs could act as a potential antimetastatic agent. Here, we showed that AdoMet upregulated the onco-suppressor miRNAs-34a/-34c/-449a and inhibited HCT-116 and Caco-2 CRC cell migration. This effect was associated with reduced expression of migration-/EMT-related protein markers. We also found that, in colorectal and triple-negative breast cancer cells, AdoMet inhibited the expression of Notch gene, which, by luciferase assay, resulted the direct target of miRNAs-34a/-34c/-449a. Gain- and loss-of-function experiments with miRNAs mimics and inhibitors demonstrated that AdoMet exerted its inhibitory effects by upregulating miRNAs-34a/-34c/-449a. Overall, these data highlighted AdoMet as a novel Notch inhibitor and suggested that the antimetastatic effects of AdoMet involve the miRNA-mediated targeting of Notch signaling pathway.
Nonalcoholic Fatty Liver Disease: Role of Medical Colleges in its Prevention and Control

N A F L D s t a n d s f o r N o n a l c o h o l i c F a t t y L i v e r Disease (NAFLD) and it is characterized by the presence of ≥5% of abnormal accumulation of fat in the liver in the absence of secondary causes of fatty liver, such as harmful alcohol use, viral hepatitis, or medications. It is a serious health concern as it encompasses a spectrum of liver abnormalities, from a simple nonalcoholic fatty liver (NAFL, simple fatty liver disease) to fibrosis, cirrhosis, and liver cancer. [1] Globally, NAFLD is a most prevalent liver disease affecting 2 billion population and its prevalence is gradually increasing. The global prevalence of this silent epidemic is currently estimated to be 24% with highest rates are reported from South America and the Middle East, followed by Asia, United States, and Europe. [2,3] The prevalence of NAFLD in India varies from 9% to 32%. [4]
Multiclass, simultaneous route and departure time choice dynamic traffic assignment with an embedded spatial queuing model

ABSTRACT This paper develops a complementarity formulation for a multi-user class, simultaneous route and departure time choice dynamic user equilibrium (DUE) model. A path-based multiclass cell transmission model (mCTM) is embedded to propagate the traffic flow on the network. Heterogeneous user classes are incorporated in the new formulation and heterogeneity is based on different preferred arrival times, cost perception for travel time, early and late arrival penalties. Multiple model properties have been showed. The proposed model is solved as an equivalent non-monotone variational inequality (VI) problem defined on a product set. A modified proximal point algorithm is used to solve the proposed non-monotone VI problem. Numerical results show that the solution approach is able to find the equilibrium or close to equilibrium solutions. The new formulation and solution approach show the feasibility of solving the multiclass DUE problem for general traffic networks.
Fly back booster design for Mach 5 scramjet launch

Scramjet powered accelerators have the potential to decrease the cost of space access by offering reusability as well as higher specific impulse compared to rockets. The University of Queensland Centre for Hypersonics (CfH) has developed a three stage to orbit, rocket-scramjet-rocket dedicated small payload (100-200kg) launcher concept for LEO and SSO called SPARTAN. Due to the restricted operational envelope of scramjet engines, a rocket first stage remains necessary for scramjet ignition at Mach 5. Therefore, a fly back rocket booster (FBB) concept has been developed for integration with SPARTAN. The goal of this study is to investigate the feasibility of utilising a pivot wing, reusable FBB to enable scramjet launch by conducting conceptual design and trajectory analysis. The FBB accelerates the launch stack to Mach 5 and 26 km altitude before staging and scramjet ignition. After separation, a re-entry aero-braking manoeuvre is performed. Wings and propellers are deployed when the FBB decelerates to Mach 0.2. The FBB then performs a coordinated turn and flies back to the launch site. Conceptual design has been performed by concurrently assessing requirements related to ascent, re-entry and fly back. This includes systems packaging, gravimetrics, flight dynamics, propulsion and aerodynamics. Pseudo-spectral optimal control is used to calculate the stack ascent trajectory. Pseudo 5Dof trajectories with an acceleration autopilot are used to model the re-entry while 3DOF trajectories are used to model the fly back. Results show successful scramjet launch conditions and return trajectory of the FBB, demonstrating the feasibility of the system.