Miracle-dz/UniFAR-FTUs huggingface dataset:
Classification of Heart Data using A Hybrid Approach

: Classification is one of the most important tasks for different applications. Most of the existing supervised classification methods are based on traditional statistics, which can provide ideal results when sample size is tending to infinity. However, only finite samples can be acquired in practice. SVM, a powerful machine method developed from statistical learning and has made significant achievement in some field. Introduced in the early 90’s, they led to an explosion of interest in machine learning. The foundations of SVM have been developed by Vapnik and are gaining popularity in field of machine learning due to many attractive features and promising empirical performance. SVM method does not suffer the limitations of data dimensionality and limited samples. This paper reports the introduction of Hybrid Approach based on the hybridization of SVM and Rough Set Exploration System (RSES). RSES is used to find reducts which then applied to SVM to obtain better classification results.
Midyear Report ∗

We present a report on ongoing activities on electron-cloud R&D for the MI upgrade. These results update and extend those presented in Refs. 1, 2. In this report we have signiﬁcantly expanded the parameter range explored in bunch intensity N b , RMS bunch length σ z and peak secondary emission yield (SEY) δ max , but we have constrained our simulations to a ﬁeld-free region. We describe the threshold behaviors in all of the above three parameters. For δ max ≥ 1 . 5 we ﬁnd that, even for N b = 1 × 10 11 , the electron cloud density, when averaged over the entire chamber, exceeds the beam neutralization level, but remains signiﬁcantly below the local neutralization level (ie., when the electron density is computed in the neighborhood of the beam). This “excess” of electrons is accounted for by narrow regions of high concentration of electrons very close to the chamber surface, especially at the top and bottom of the chamber, akin to virtual cathodes. These virtual cathodes are kept in equilibrium, on average, by a competition between space-charge forces (including their images) and secondary emission, a mechanism that shares some features with the space-charge saturation of the current in a diode at high ﬁelds. For N b = 3 × 10 11 the electron cloud build-up growth rate and saturation density have a strong dependence on σ z as σ z decreases below ∼ 0 . 4 m, when the average electron-wall impact energy roughly reaches the energy E max where δ peaks. We also present improved results on emittance growth simulations of the beam obtained with the code WARP/POSINST in quasi-static mode, in which the beam-(electron cloud) interaction is lumped into N s “stations” around the ring, where N s = 1 , 2 , . , 9. The emittance shows a rapid growth of ∼ 20% during the ﬁrst ∼ 100 turns, followed by a much slower growth rate of ∼ 0 . 03%/turn. Concerning the electron cloud detection technique using microwave transmission, we present an improved dispersion relation for the TE mode of the microwaves, and a corresponding analytic estimate of the phase shift.
University of Birmingham Passive and post-exercise cold-water immersion augments PGC-1alpha and VEGF expression in human skeletal muscle.

increased in CWI ~1.9-fold ( P = 0.03) and 2.2-fold ( P = 0.009) at 3 and 6 h post-immersion. Conclusions Data confirm post-exercise CWI augments the acute exercise-induced expression of PGC-1 α mRNA in human skeletal muscle compared to exercise per se. Addi-tionally CWI per se mediates the activation of PGC-1 α and VEGF mRNA expression in human skeletal muscle. Cold water may therefore enhance the adaptive response to acute exercise. Abstract Purpose We tested the hypothesis that both post-exercise and passive cold water immersion (CWI) increases PGC-1 α and VEGF mRNA expression in human skeletal muscle. Method Study 1 Nine males completed an intermittent running protocol (8 × 3-min bouts at 90 % ˙ V O 2 max , interspersed with 3-min active recovery (1.5-min at 25 % and 1.5-min at 50 % ˙ V O 2 max ) before undergoing CWI (10 min at 8 °C) or seated rest (CONT) in a counterbalanced, ran-domised manner. Study 2 Ten males underwent an identical CWI protocol under passive conditions. Results Study 1 PGC-1 α mRNA increased in CONT (~3.4-fold; P < 0.001) and CWI (~5.9-fold; P < 0.001) at 3 h post-exercise with a greater increase observed in CWI ( P < 0.001). VEGFtotal mRNA increased after CWI only (~2.4-fold) compared with CONT (~1.1-fold) at 3 h postexercise ( P < 0.01). Study 2 Following CWI, PGC-1 α mRNA expression was significantly increased ~1.3-fold ( P = 0.001) and 1.4-fold ( P = 0.0004) at 3 and 6 h, respectively. Similarly, VEGF165 mRNA was significantly
Identification and Differentiation of Mycobacterium Avium Subspecies Paratuberculosis Isolates Using and pAM-3 as a DNA Probe

Background: Mycobacteriu avium subsp.paratuberculosis (MAP) is the causative agent of Johne’s disease. It is a very slow growing bacterium on synthetic medium. The use of conventional methods for diagnosis is time consuming and not accurate. Objectives: The use of molecular biological techniques for fast and accurate diagnosis of Mycobacterium avium subsp.paratuberculosis isolates. Materials and methods: DNA was extracted and prepared from four Mycobacterium avium subsp.paratuberculosis and four Mycobacterium tuberculosis bovis isolates. The extracted DNA was subjected to PCR by using specific primers and the isolates were distinguished and differentiated by hybridization technique using pAM-3 specific probe developed in New Zealand. Results: The PCR products gave the requested DNA fragment of 163 base pairs. The probe reacted specifically with targeted DNA fragment of paratubreculosis bacterial isolates but not with tuberculosis bovis isolates. Conclusion: The use of PCR and specific DNA probe for the diagnosis of MAP is a fast and accurate method for diagnosis of MAP.
A Mechanistic and Translational Pharmacokinetic-Pharmacodynamic Model of Abicipar Pegol and VEGF Inhibition

Abicipar pegol (abicipar) is a novel DARPin ® therapeutic and highly potent vascular endothelial growth factor (VEGF) inhibitor intended for the treatment of neovascular age-related macular degeneration (nAMD). Here we develop a translational pharmacokinetic/pharmacodynamic (PK/PD) model for abicipar to guide dosing regimens in the clinic. The model incorporated abicipar-VEGF binding kinetics, VEGF expression levels and VEGF turnover rates to describe the ocular and systemic PK data collected from the vitreous, aqueous humor (AH), choroid, retina, and serum of rabbits after a 1 mg abicipar intravitreal (IVT) dose. The model was translated to human using human-specific mechanistic parameters and refitted to human serum and AH concentrations from patients with diabetic macular edema (DME) and nAMD. The model was then used to simulate 8-, 12- (quarterly) and 16-week dosing intervals in the clinic. Simulations of 2 mg abicipar IVT at 8-week or quarterly dosing in humans indicates minimum steady-state vitreal concentrations are maintained above both in-vitro IC 50 and in-vivo human IC 50 values. The model predicted virtually complete VEGF inhibition for the 8-week and quarterly dosing schedule during the 52-week treatment period. In the 16-week schedule, clinically significant VEGF inhibition was maintained during the 52-week period. The model quantitatively described abicipar-VEGF target engagement leading to rapid reduction of VEGF and a long duration of VEGF inhibition demonstrating the clinical feasibility of up to a 16-week dosing interval. Abicipar is predicted to reduce IVT dosing compared to other anti-VEGF therapies with the potential to lessen patient treatment burden. Results from the HAWK and HARRIER phase III In summary, we performed mechanism-based modeling and simulation to better understand the pharmacology, PK and PD of abicipar following IVT injections in rabbits and in human. The model was utilized to explore the feasibility of longer dose intervals than monthly injections in nAMD patients. The results confirm that abicipar 8-week and quarterly dosing schedules provide sufficient exposure for maintaining virtually complete VEGF inhibition during the 52-week period—results from the CEDAR and SEQUOIA phase 3 studies confirmed our prediction. In addition, simulations showed that abicipar Q16 schedule also maintains significant VEGF inhibition during the 52-week period, lending feasibility for investigation of this schedule in the clinic. The extended duration of action for abicipar compared to existing therapies may reduce the treatment burden for patients and would be an important advancement in the treatment of retinal ischemic diseases.
On the Structure of Complete Local Rings

The concept of a local ring was introduced by Krull [2], who defined it as a Noetherian ring R (we say that a commutative ring R is Noetherian if every ideal in R has a finite basis and if R contains the identity) which has only one maximal ideal m. If the powers of m are defined as a system of neighbourhoods of zero, then R becomes a topological ring satisfying the first axiom of countability, And the notion was studied recently by C. Chevalley and I. S. Cohen. Cohen [1] proved the structure theorem for complete rings besides other properties of local rings.
PROOF COVER SHEET

The goal of this investigation was to perform a comparative analysis on how accurately 11 routinely-used in silico programs correctly predicted the mutagenicity of test compounds that contained either bulky or electron-withdrawing substituents. To our knowledge this is the first study of its kind in the literature. Such substituents are common in many pharmaceutical agents so there is a significant need for reliable in silico programs to predict precisely whether they truly pose a risk for mutagenicity. The predictions from each program were compared to experimental data derived from the Ames II test, a rapid reverse mutagenicity assay with a high degree of agreement with the traditional Ames assay. Eleven in silico programs were evaluated and compared: Derek for Windows, Derek Nexus, Leadscope Model Applier (LSMA), LSMA featuring the in vitro microbial Escherichia coli–Salmonella typhimurium TA102 A-T Suite (LSMA þ ), TOPKAT, CAESAR, TEST, ChemSilico (±S9 suites), MC4PC and a novel DNA docking model. The presence of bulky or electron-withdrawing functional groups in the vicinity of a mutagenic toxicophore in the test compounds clearly affected the ability of each in silico model to pre- dict non-mutagenicity correctly. This was because of an over reliance on the part of the programs to provide mutagenicity alerts when a particular toxicophore is present irrespective of the structural envir- onment surrounding the toxicophore. From this investigation it can be concluded that these models provide a high degree of specificity (ranging from 71% to 100%) and are generally conservative in their predictions in terms of sensitivity (ranging from 5% t o 78%). These values are in general agreement with most other comparative studies in the literature. Interestingly, the DNA docking model was the most sensitive model evaluated, suggesting a potentially useful new mode of screening for mutagens. Another important finding was that the combination of a quantitative structure–activity relationship and an expert rules system appeared to offer little advantage in terms of sensitivity, despite of the requirement for such a screening paradigm under the ICH M7 regulatory guideline.
Cyclin-Speciﬁc Control of Ribosomal DNA Segregation (cid:1)

Following chromosome duplication in S phase of the cell cycle, the sister chromatids are linked by cohesin. At the onset of anaphase, separase cleaves cohesin and thereby initiates sister chromatid separation. Separase activation results from the destruction of its inhibitor, securin, which is triggered by a ubiquitin ligase called the anaphase-promoting complex (APC). Here, we show in budding yeast that securin destruction and, thus, separase activation are not sufﬁcient for the efﬁcient segregation of the repetitive ribosomal DNA (rDNA). We ﬁnd that rDNA segregation also requires the APC-mediated destruction of the S-phase cyclin Clb5, an activator of the protein kinase Cdk1. Mutations that prevent Clb5 destruction are lethal and cause defects in rDNA segregation and DNA synthesis. These defects are distinct from the mitotic-exit defects caused by stabilization of the mitotic cyclin Clb2, emphasizing the importance of cyclin speciﬁcity in the regulation of late-mitotic events. Efﬁcient rDNA segregation, both in mitosis and meiosis, also requires APC-dependent destruction of Dbf4, an activator of the protein kinase Cdc7. We speculate that the dephosphorylation of Clb5-speciﬁc Cdk1 substrates and Dbf4-Cdc7 substrates drives the resolution of rDNA in early anaphase. The coincident destruction of securin, Clb5, and Dbf4 coordinates bulk
on among Irish Differential Impact of Central Venous Catheters verses Arteriovenous Fistulae on Quality of Life among Irish Haemodialysis Patients

: Background: Arteriovenous fistulae (AVF) have superior clinical outcomes compared to central venous catheters (CVC) among haemodialysis (HD) patients. Yet, there is increasing recognition that health-related quality of life (HRQoL) may be more important to patients than survival and that differences may exist between AVF and CVCs in this regard. This study compared HRQoL between AVF and CVC in an Irish cohort. Methods: We conducted a cross-sectional survey among prevalent haemodialysis patients (n=119) dialysing with either an AVF or CVC at a regional programme. The Short Form 36 (SF-36) and a validated Vascular Access Questionnaire (SF-VAQ) compared QoL between AVF and CVC in domains of physical functioning, social functioning and dialysis complications. Multivariable logistic regression compared differences between groups for outcomes of physical functioning, social functioning and dialysis complications expressed as adjusted odds ratios and 95% CI. Results: Mean age was 66.1 years, 52.1% were using an AVF while 47.9% had a CVC. Patients dialysing with an AVF were more satisfied with their access when asked directly (6.2 vs 5.0, P<0.01). Abstract: Background: Arteriovenous fistulae (AVF) have superior clinical outcomes compared to central venous catheters (CVC) among haemodialysis (HD) patients. Yet, there is increasing recognition that health-related quality of life (HRQoL) may be more important to patients than survival and that differences may exist between AVF and CVCs in this regard. This study compared HRQoL between AVF and CVC in an Irish cohort. Methods: We conducted a cross-sectional survey among prevalent haemodialysis patients (n=119) dialysing with either an AVF or CVC at a regional programme. The Short Form 36 (SF-36) and a validated Vascular Access Questionnaire (SF-VAQ) compared QoL between AVF and CVC in domains of physical functioning, social functioning and dialysis complications. Multivariable logistic regression compared differences between groups for outcomes of physical functioning, social functioning and dialysis complications expressed as adjusted odds ratios and 95% CI. Results: Mean age was 66.1 years, 52.1% were using an AVF while 47.9% had a CVC. Patients dialysing with an AVF were more satisfied with their access when asked directly (6.2 vs 5.0, P<0.01). Physical functioning scores for bleeding, swelling and bruising were significantly higher for AVF than CVC (P<0.005 for all). In contrast, patients with CVC
Simulation and Experimental Research on the Liquid Spreading Behavior in the Wire Sawn Kerf

The significance of liquid for abrasive wire sawing has been demonstrated by researchers with considerable studies. However, its performance in the spreading behavior is limited by the development trend of larger area wafer and narrower slicing kerf. Nevertheless, studies on the liquid spreading behavior in the wire sawing kerf are awfully limited. In this paper, a 3D CFD (Computational Fluid Dynamics) model was presented to simulate the liquid spreading behavior in the kerf. Where a VOF (Volume of Fluid) method with a CSF (Continuum Surface Force) model is used to simulate multiphase flow, and an empirical correlation for characterizing the liquid dynamic contact angle is introduced using UDF (User Defined Functions). Parametric simulations were performed on the kerf area, kerf width, liquid viscosity, liquid surface tension and liquid velocity at the inlet area of the kerf. Verification experiments are conducted for the validity of the simulation model. From both simulation and experimental results, three typical liquid spreading regimes in the kerfs are found, which perform distinct different effects on wire sawing. Moreover, the limiting conditions of the three spreading regimes are identified by non-dimensional analysis, then a prediction model is proposed for the liquid spreading regime, by given a set of Weber number and Capillary number. For wire sawing, the increase in the wafer area will not change the liquid spreading regime in the kerf, but the reduction of the kerf width will significantly hinder the liquid spreading behavior. By adjusting the physical properties and supply conditions of the liquid, the spreading regime can be effectively converted to facilitate wire sawing.
D EVELOPING C APABILITIES FOR O NGOING L EARNING AND C HANGE IN I NTERMEDIARY P ROGRAMS

In dynamic environments, firms seek to build capabilities which will permit them to become innovation and change ready. Programs offered by intermediaries, while varying greatly in content and format, are designed to support those firms wishing to enhance their competitiveness. Firms which participate in intermediary programs have displayed their willingness to overcome deficiencies or barriers to competitiveness through acquiring knowledge which is external to the firm. This paper reports on interviews with 24 firms who were involved in a MAP or TAP program offered by QMI Solutions. The findings of the research suggest that knowledge intermediaries serve to disrupt organisational paths and in so doing establish mechanisms for ongoing learning and change. They do this first by disrupting the firm with a positive learning experience and also by establishing processes for developing new relationships and access to knowledge which are critical for learning and change. It is the experience of learning through knowledge exchange which can trigger the pursuit of new paths and it is the processes involving new relations and knowledge processing that provides the micro-foundations for ongoing learning and change. This suggests that the role of intermediaries goes well beyond merely knowledge transfer to include longer term effects on the capability of organisations to innovate, which is critical to economic competitiveness and the survival rate of firms.
Association of Interleukin-1 (cid:3) Gene Polymorphism with Body Mass in

diabetes mellitus (2 , 7) , hypertension (8) , and sleep apnea syndrome (SAS) (9) . In patients with acromegaly, im-paired glucose tolerance, arterial hypertension, and SAS are frequent findings, and macrovascular disease is a common complication (10) . The aim of this study was to measure sE-selectin in patients with acromegaly before and after pituitary surgery and to analyze whether sE-selectin concentrations are related to disease insulin resistance, hypertension, or in group
H IGH T EMPERATURE N ANOINDENTATION : T HE S TATE OF THE A RT AND F UTURE C HALLENGES

Nanoindentation measurement capabilities at elevated temperatures have developed considerably over the last two decades. Commercially available systems can now perform stable indentation testing at temperatures up to ~800 °C with thermal drift levels similar to those present at room temperature. The thermal management and measurement techniques necessary to achieve this are discussed here, with particular emphasis on systems featuring independent heating of both the indenter and the sample. To enable measurements at temperatures where oxidation of the indenter and/or sample are a concern, vacuum nanoindentation techniques have also been developed. A natural extension of testing in vacuo is elevated temperature nanoindentation in situ in the scanning electron microscope, and the additional requirements for and benefits of this are discussed. Finally, several new emerging testing techniques are introduced: thermal cycling/fatigue, interfacial thermal resistance measurement and small scale transient plasticity measurements.
Fimbriae of uropathogenic Proteusmirabilis

Proteus mirabilis is a common causative agent of cystitis and pyelonephritis in patients with urinary catheters or structural abnormalities of the urinary Several types of ﬁmbriae, which are potentially involved in adhesion to the uroepithelium, can be expressed simultaneously by P. mirabilis : mannose-resis-tant/ Proteus -like (MR/P) ﬁmbriae, P. mirabilis ﬁmbriae (PMF), uroepithelial cell adhesin (UCA), renamed by some authors nonagglutinating ﬁmbriae (NAF), and ambient-temperature ﬁmbriae (ATF). Proteus mirabilis is a common cause of bioﬁlm formation on catheter material and MR/P ﬁmbriae are involved in this process. The considerable serious pathology caused by P. mirabilis in the urinary tract warrants the development of a prophylactic vaccine, and several studies have pointed to MR/P ﬁmbriae as a potential target for immunization. This article reviews P. mirabilis ﬁmbriae with regard to their participation in uropathogenesis, bioﬁlm formation and as vaccine targets.
Optimal Multi-Modes Switching with the Switching Cost not necessarily Positive

In this paper, we study the m-states optimal switching problem in finite horizon, when the switching cost functions are arbitrary and can be positive or negative. This has an economic incentive in terms of central evaluation in cases where such organizations or state grants or financial assistance to power plants that promotes green energy in their production activity or what uses less polluting modes in their production. We show existence for optimal strategy via a verification theorem then we show existence and uniqueness of the value processes by using an approximation scheme. In the markovian framework we show that the value processes can be characterized in terms of deterministic continuous functions of the state of the process. Those latter functions are the unique viscosity solutions for a system of m variational partial differential inequalities with inter-connected obstacles.
OPTH_A_256991 2237..2244

Point your SmartPhone at the code above. If you have a QR code reader the video abstract will appear. Or use: https://youtu.be/z-HV86x0y3M Background: A low-detail, glowing fixation device was added to GoCheck Kids (GCK) photoscreener in the hope of unmasking hyperopia and amblyopia risk factors (ARF). Methods: Pediatric eye patients were screened by GCK and 2WIN photoscreeners, and Retinomax autorefractor before being compared to AAPOS ARFs. Results: Screening was attempted by 131 children who then had school bus accommodation-relaxing skiascopy (SBA-RS) before cycloplegic examination. By 2013 AAPOS uniform guidelines, sensitivity/specificity for GCK was 87%/68%, for 2WIN 87%/71% and for Retinomax 79%/68%. Detection of amblyopia had sensitivity/specificity by GCK of 78%/ 63%, for 2WIN 79%/65% and for Retinomax 77%/68%. Inconclusive screens were seven for GCK, six for 2WIN and 13 for Retinomax. Mean hyperopia for GCK (+2.49±0.74 D) was similar to cycloplegic refraction (+2.93±0.72 D) and SBA-RS (+2.80±0.82 D) while GCK was slightly more than Retinomax (+1.59±0.93 D, p=0.13) but significantly more than 2WIN (+1.02±0.49 D, p<0.01). Conclusion: GCK, 2WIN and Retinomax had similar validity detecting uniform amblyopia risk factors and amblyopia itself. The nondetailed glow fixation device allowed GCK to uncover substantial hyperopia while the detailed flashing fixation devices on 2WIN and Retinomax seemed to stimulate accommodation in some hyperopic children. Clinical Trials Registry: NCT04297969. Data Access: http://www.abcd-vision.org/refer ences/GCK%20glow%202WIN%20deidentify.pdf. Précis: A glow fixation device on a smart phone photoscreener allowed robust detection of hyperopia.