Miracle-dz/UniFAR-FTUs huggingface dataset:
Tolerability and effectiveness of albuvirtide combined with dolutegravir for hospitalized people living with HIV/AIDS

Treatment options for hospitalized people living with HIV/AIDS (PLWHA) with opportunistic infections and comorbidities are limited in China. Albuvirtide (ABT), a new peptide drug, is a long-acting HIV fusion inhibitor with limited drug-drug interactions and fast onset time. This single-center, retrospective cohort study investigated the effectiveness and safety of ABT plus dolutegravir (DTG) therapy in a real-world setting. We performed a chart review on the electronic patient records for hospitalized PLWHA using ABT plus DTG between April and December 2020. The clinical outcomes were retrospectively analyzed. Among 151 PLWHA (mean age 47.6 ± 15.9 years), 140 (93%) had at least 1 episode of bacterial and/or fungal infections and 64 (42%) had other comorbidities including syphilis, hepatitis B, and/or hypertension. ABT plus DTG was given to 87 treatment-naïve (TN) and 64 treatment-experienced (TE) PLWHA. Regardless of treatment history, mean HIV-1 RNA levels significantly decreased from 4.32 log10copies/mL to 2.24 log10copies/mL, 2.10 log10copies/mL and 1.89 log10copies/mL after 2, 4 and 8 weeks of treatment, respectively (P < .0001). Compared with baseline mean CD4 + T-cell counts of 122.72 cells/μL, it increased to 207.87 cells/μL (P = .0067) and 218.69 cells/μL (P = .0812) after 4 and 8 weeks of treatment. Except for limited laboratory abnormalities such as hyperuricemia, increased creatinine level, and hyperglycemia observed after treatment, no other clinical adverse events were considered related to ABT plus DTG. Data suggests that ABT plus DTG is safe and effective for critically-ill hospitalized PLWHA. In view of the rapid viral load suppression and restoration of CD4 + count within 8 weeks of treatment, its clinical application warrants further investigation.
Systems genetics approaches for understanding complex traits with relevance for human disease

Quantitative traits are often complex because of the contribution of many loci, with further complexity added by environmental factors. In medical research, systems genetics is a powerful approach for the study of complex traits, as it integrates intermediate phenotypes, such as RNA, protein, and metabolite levels, to understand molecular and physiological phenotypes linking discrete DNA sequence variation to complex clinical and physiological traits. The primary purpose of this review is to describe some of the resources and tools of systems genetics in humans and rodent models, so that researchers in many areas of biology and medicine can make use of the data.
Propofol-Based Anesthesia Maintenance and/or Volatile Anesthetics during Intracranial Aneurysm Repair: A Comparative Analysis of Neurological Outcomes

Background: Volatile and intravenous anesthetics have substantial effects on physiological functions, notably influencing neurological function and susceptibility to injury. Despite the importance of the anesthetic approach, data on its relative risks or benefits during surgical clipping or endovascular treatments for unruptured intracranial aneurysms (UIAs) remains scant. We investigated whether using volatile anesthetics alone or in combination with propofol infusion yields superior neurological outcomes following UIA obliteration. Methods: We retrospectively reviewed 1001 patients who underwent open or endovascular treatment for UIA, of whom 596 had short- and long-term neurological outcome data (modified Rankin Scale) recorded. Multivariable ordinal regression analysis was performed to examine the association between the anesthetic approach and outcomes. Results: Of 1001 patients, 765 received volatile anesthetics alone, while 236 received propofol infusion and volatile anesthetics (combined anesthetic group). Short-term neurological outcome data were available for 619 patients and long-term data for 596. No significant correlation was found between the anesthetic approach and neurologic outcomes, irrespective of the type of procedure (open craniotomy or endovascular treatment). The combined anesthetic group had a higher rate of ICU admission (p < 0.001) and longer ICU and hospital length of stay (LOS, p < 0.001). Similarly, a subgroup analysis revealed longer ICU and hospital LOS (p < 0.0001 and p < 0.001, respectively) in patients who underwent endovascular UIA obliteration under a combined anesthetic approach (n = 678). Conclusions: The addition of propofol to volatile anesthetics during UIA obliteration does not provide short- or long-term benefits to neurologic outcomes. Compared to volatile anesthetics alone, the combination of propofol and volatile anesthetics may be associated with an increased rate of ICU admission, as well as longer ICU and hospital LOS.
Adaptive Ionization-Induced Tunable Electric Double Layer for Practical Zn Metal Batteries over Wide pH and Temperature Ranges.

The violent side reactions of Zn metal in aqueous electrolyte lead to sharp local-pH fluctuations at the interface, which accelerate Zn anode breakdown; thus, the development of an optimization strategy to accommodate a wide pH range is particularly critical for improving aqueous Zn metal batteries. Herein, we report a pH-adaptive electric double layer (EDL) tuned by glycine (Gly) additive with pH-dependent ionization, which exhibits excellent capability to stabilize Zn anodes in wide-pH aqueous electrolytes. It is discovered that a Gly-ionic EDL facilitates the directed migration of charge carriers in both mildly acidic and alkaline electrolytes, leading to the successful suppression of local saturation. It is worth mentioning that the regulation effect of the additive concentration on the inner Helmholtz plane (IHP) structure of Zn electrodes is clarified in depth. It is revealed that the Gly additives without dimerization can develop orderly and dense vertical adsorption within the IHP to effectively reduce the EDL repulsive force of Zn2+ and isolate H2O from the anode surface. Consequently, they Zn anode with tunable EDL exhibits superior electrochemical performance in a wide range of pH and temperature, involving the prodigious cycle reversibility of 7000 h at Zn symmetric cells with ZnSO4-Gly electrolytes and an extended lifespan of 50 times in Zn symmetric cells with KOH-Gly electrolytes. Moreover, acidic Zn powder||MnO2 pouch cells, and alkaline high-voltage Zn||Ni0.8Co0. 1Mn0.1O2 cells, and Zn||NiCo-LDH cells also deliver excellent cycling reversibility. The tunable EDL enables the ultrahigh depth of discharge (DOD) of 93%. This work elucidates the design of electrolyte additives compatible in a wide range of pH and temperature, which might cause inspiration in the fields of practical multiapplication scenarios for Zn anodes.
The Impact of Spiritual Well-Being on the Quality of Life of Cancer Patients: A Cross-Sectional Study

Background: Quality of life is a multidimensional concept that involves physical, social, emotional, and functional well-being. Spirituality represents a potentially influential factor in the quality of life. This study aimed to evaluate the quality of life and spirituality among cancer patients. Methods: A cross-sectional study was carried out on 354 cancer patients in Palestine. A self-administered questionnaire was used for data collection. The questionnaire was made up of 4 sections: sociodemographic factors, clinical data, FACT-G, and FACIT-sp. Results: A total of 354 cancer patients with a mean age of 46.4 ± 15.3 years were enrolled in the study. The spiritual well-being of patients reported in this study was measured by using the median FACIT-Sp total score, and it was 35 (IQR: 29-42). The quality of life of patients was measured using the median of the FACT-G total score, and it was 63 (IQR: 52-85). The FACT-G score was significantly variable based on several factors including age, marital status, cancer type, presence of metastasis, presence of treatment side effects, and the period since diagnosis (P-value < .05). The FACIT-Sp total score had a significantly strong positive relationship with FACT-G total score (r = .705, P < .001). Moreover, moderate to strong significant correlations were found between spirituality and quality of life subscales. Conclusions: Quality of life among cancer patients is affected by their basic and clinical characteristics and is highly correlated with their spirituality level. Thus, addressing palliative support through spiritual care besides primary clinical treatment is of great importance to improve the quality of life among cancer patients.
Low-Loss Paper-Substrate Triple-Band-Frequency Reconfigurable Microstrip Antenna for Sub-7GHz Applications

In this paper, a low-cost resin-coated commercial-photo-paper substrate is used to design a printed reconfigurable multiband antenna. The two PIN diodes are used mainly to redistribute the surface current that provides reconfigurable properties to the proposed antenna. The antenna size of 40 mm × 40 mm × 0.44 mm with a partial ground, covers wireless and mobile bands ranging from 1.91 GHz to 6.75 GHz. The parametric analysis is performed to achieve optimized design parameters of the antenna. The U-shaped and C-shaped emitters are meant to function at 2.4 GHz and 5.9 GHz, respectively, while the primary emitter is designed to operate at 3.5 GHz. The proposed antenna achieved peak gain and radiation efficiency of 3.4 dBi and 90%, respectively. Simulated and measured results of the reflection coefficient, radiation pattern, gain, and efficiency show that the antenna design is in favorable agreement. Since the proposed antenna achieved wideband (1.91–6.75 GHz) using PIN diode configuration, using this technique the need for numerous electronic components to provide multiband frequency is avoided.
U.S. EPA / FKNMS Coral Reef Evaluation and Monitoring Project

Goal The Coral Reef Evaluation and Monitoring Project (CREMP) is part of the Water Quality Protection Program for the Florida Keys National Marine Sanctuary (FKNMS). The goal of this project is to utilize broad spatial coverage, repeated sampling, and statistically valid findings to document status and trends of coral communities within the Sanctuary. As coral reef monitoring is integrated with the seagrass and water quality monitoring projects, the results can be used to focus research on determining causality and to fine tune and evaluate management decisions.
Non-chemical weed control in sugar beet crop under intensive and conservation soil tillage: I. Crop weediness

The effect of non-chemical weed control under different soil tillage on sugar beet crop weediness was investigated at the Experimental Station of the Lithuanian University of Agriculture in a silty loam Luvisol during the period of 2004-2005. The aim of the experiment was to establish the influence of soil tillage intensity, living and straw mulch on the number and dry mass of weeds in the sugar beet crop. Treatments of the trial were the following: I. Soil tillage (factor A): 1. intensive (straw loosening, moldboard ploughing; control variant) (IT); 2. conservation (straw loosening) (CT); II. Non-chemical weed control (factor B): 1. hand weeding, twice (control variant) (HW); 2. spring barley living mulch (SBM); 3. annual ryegrass living mulch (ARM); 4. white mustard living mulch (WMM); 5. spring oilseed rape living mulch (SRM); 6. winter wheat straw mulch (WSM). According to the results of investigations, in conditions of intensive soil tillage the highest choking of weeds was observed by annual ryegrass (ARM) and white mustard (WMM) living mulches. In sugar beet row spaces, which were mulched with winter wheat straw mulch (WSM) there was a large number of weeds but their mass was not high. Conversely, in conservation soil tillage conditions the lowest weed infestation and dry mass of weeds were observed in straw mulch (WSM) up to 4 cm. White mustard living mulch (WMM) also influenced weed dry mass decrease though its number was high.
How Do Most Young Moderate Hyperopes Avoid Strabismus?

Purpose Uncorrected hyperopic children must overcome an apparent conflict between accommodation and vergence demands to focus and align their retinal images. This study tested hypotheses about simultaneous accommodation and vergence performance of young hyperopes to gain insight into ocular motor strategies used to maintain eye alignment. Methods Simultaneous eccentric photorefraction and Purkinje image tracking were used to assess accommodative and vergence responses of 26 adult emmetropes (AE) and 94 children (0–13 years) viewing cartoons. Children were habitually uncorrected (CU) (spherical equivalent refractive error [SE] −0.5 to +4 D), corrected and aligned (CCA), or corrected with a history of refractive esotropia (CCS). Accommodative and vergence accuracy, dissociated heterophoria, and vergence/accommodation ratios in the absence of retinal disparity cues were measured for 33- and 80-cm viewing distances. Results In binocular viewing, median accommodative lags for 33 cm were 1.0 D (AE), 1.33 D (CU), 1.25 D (CCA), and 1.0 D (CCS). Median exophorias at 80 and 33 cm were 1.2 and 4.5 pd (AE), 0.8 and 2.5 pd (CU), and 0 and 1.2 pd (CCA), respectively. Without disparity cues, most response vergence/accommodation ratios were between 1 and 2 meter angle/D (∼5–10 pd/D) (69% of AE, 44% of CU, 60% of CCA, and 50% of CCS). Conclusions Despite apparent conflict in motor coupling, uncorrected hyperopes were typically exophoric and achieved adultlike accuracy of both vergence and accommodation simultaneously, indicating ability to compensate for conflicting demands rather than bias to accurate vergence while tolerating inaccurate accommodation. Large lags and esophoria are therefore atypical. This analysis provides normative guidelines for clinicians and a deeper mechanistic understanding of how hyperopes avoid strabismus.
Data augmentation using generative models for track intrusion detection

The objective of this work is to address the problem of detecting track intruders in railway systems using deep learning-based algorithms. Unauthorized entry onto railway tracks poses a significant risk of collisions between trains and humans. However, intrusion discrimination algorithms often suffer from a lack of learning data and data imbalance issues. To overcome these challenges, this research proposes an algorithm that combines generative models and classification networks. Generative models are utilized to generate synthetic intrusion data by learning the underlying distribution of available data and creating new samples resembling the original data. The augmented intrusion data is then used to train deep neural networks to accurately identify intrusions. The proposed algorithm is evaluated using real data sets, demonstrating its effectiveness in overcoming limited learning data and data imbalance issues. By augmenting intrusion data using generative models, the algorithm achieves improved accuracy compared to traditional approaches. In conclusion, the algorithm presented in this work provides a solution for detecting track intruders in railway systems. By leveraging generative models to augment limited intrusion data and utilizing classification networks for intrusion discrimination, the algorithm demonstrates improved performance in accurately identifying intrusions. This research highlights the potential of deep learning-based approaches in enhancing railway safety and recommends further exploration and application of these methods in real-world settings.
Rho of Plants patterning: linking mathematical models and molecular diversity

Abstract ROPs (Rho of Plants) are plant specific small GTPases involved in many membrane patterning processes and play important roles in the establishment and communication of cell polarity. These small GTPases can produce a wide variety of patterns, ranging from a single cluster in tip-growing root hairs and pollen tubes to an oriented stripe pattern controlling protoxylem cell wall deposition. For an understanding of what controls these various patterns, models are indispensable. Consequently, many modelling studies on small GTPase patterning exist, often focusing on yeast or animal cells. Multiple patterns occurring in plants, however, require the stable co-existence of multiple active ROP clusters, which does not occur with the most common yeast/animal models. The possibility of such patterns critically depends on the precise model formulation. Additionally, different small GTPases are usually treated interchangeably in models, even though plants possess two types of ROPs with distinct molecular properties, one of which is unique to plants. Furthermore, the shape and even the type of ROP patterns may be affected by the cortical cytoskeleton, and cortex composition and anisotropy differ dramatically between plants and animals. Here, we review insights into ROP patterning from modelling efforts across kingdoms, as well as some outstanding questions arising from these models and recent experimental findings.
ELM—the Eukaryotic Linear Motif resource—2024 update

Abstract Short Linear Motifs (SLiMs) are the smallest structural and functional components of modular eukaryotic proteins. They are also the most abundant, especially when considering post-translational modifications. As well as being found throughout the cell as part of regulatory processes, SLiMs are extensively mimicked by intracellular pathogens. At the heart of the Eukaryotic Linear Motif (ELM) Resource is a representative (not comprehensive) database. The ELM entries are created by a growing community of skilled annotators and provide an introduction to linear motif functionality for biomedical researchers. The 2024 ELM update includes 346 novel motif instances in areas ranging from innate immunity to both protein and RNA degradation systems. In total, 39 classes of newly annotated motifs have been added, and another 17 existing entries have been updated in the database. The 2024 ELM release now includes 356 motif classes incorporating 4283 individual motif instances manually curated from 4274 scientific publications and including >700 links to experimentally determined 3D structures. In a recent development, the InterPro protein module resource now also includes ELM data. ELM is available at: http://elm.eu. org.
Imaging‐proteomic analysis for prediction of neoadjuvant chemotherapy responses in patients with breast cancer

Optimizing patient selection for neoadjuvant chemotherapy in patients with breast cancer remains an unmet clinical need. Quantitative features from medical imaging were reported to be predictive of treatment responses. However, the biologic meaning of these latent features is poorly understood, preventing the clinical use of such noninvasive imaging markers. The study aimed to develop a deep learning signature (DLS) from pretreatment magnetic resonance imaging (MRI) for predicting responses to neoadjuvant chemotherapy in patients with breast cancer and to further investigate the biologic meaning of the DLS by identifying its underlying pathways using paired MRI and proteomic sequencing data.
Integrierte Tierärztliche Bestandsbetreuung und Selektives Trockenstellen in Deutschland

Zusammenfassung Ziel Ermittlung von aktuellen Informationen über Entwicklung und Durchführung der Integrierten Tierärztlichen Bestandsbetreuung (ITB) sowie Verbreitung des Selektiven Trockenstellens (ST) in deutschen Tierarztpraxen und Milchviehbetrieben. Zudem Darstellung von Unterschieden oder Gemeinsamkeiten zwischen Tierärzten mit und ohne ITB in Bezug auf die Anwendung von Verfahren zum ST. Material und Methoden 600 Fragebögen wurden im Rahmen von 7 Fortbildungen an Nutztierpraktiker verteilt. Die Teilnahme war freiwillig und anonym. Die Datenauswertung erfolgte mittels deskriptiver Statistik, linearer und logistischer Regression. Ergebnisse Der Rücklauf betrug 39,3% (n=236). Eine ITB wurde von 54,2% (n=128) der Tierärzte durchgeführt. Von 75% (n=177) der Tierärzte wurden Verfahren zum ST angewendet. Dabei wurden verschiedene Entscheidungskriterien auf Herden- (81,6%, n=142) und Einzeltierebene (97,7%, n=172) genutzt. Eine Erfolgskontrolle des Verfahrens wurde häufiger in Betrieben von Tierärzten mit ITB (66%, n=66) als ohne ITB (41%, n=28) durchgeführt. Je mehr Betriebe im Rahmen einer ITB betreut wurden, desto höher war der Anteil der Betriebe, in denen selektiv trockengestellt wurde. Eine steigende Chance auf eine gleichbleibende oder verbesserte Eutergesundheit war mit ST-Betrieben assoziiert, in denen gleichzeitig eine ITB durchgeführt wurde (OR: 1,025; p<0,05). Die Beratung bei Problemen in der Trockenstehzeit (OR: 3,639; p<0,05), die Häufigkeit, mit der Tierärzte die Landwirte (OR: 1,595; p<0,05) und Landwirte die Tierärzte auf ST ansprachen (OR: 1,538; p<0,05), sowie die Beratungshäufigkeit zum Trockenstellmanagement (OR:1,608; p<0,05) hatten einen positiven Einfluss auf die Wahrscheinlichkeit, ob ST in einem Betrieb durchgeführt wurde und ob dies erfolgreich war. Schlussfolgerungen Sowohl ITB als auch ST sind nach vorliegenden Daten etablierte Bestandteile der tierärztlichen Tätigkeit in Rinderpraxen. Das ST wird in der Praxis zum Teil im Rahmen kontrollierter Verfahren mit Erfolgskontrolle umgesetzt. Die Durchführung einer ITB war positiv mit der Anzahl der Betriebe assoziiert, in denen selektiv trockengestellt wurde, und mit dem Eutergesundheitsstatus, wenn in einem Betrieb ITB und ST kombiniert durchgeführt wurden. Beratungsangebot und -häufigkeit der Tierärzte haben einen wesentlichen Einfluss auf eine Antibiotikareduktion durch ST.
Modified maximum-likelihood classification algorithms and their application to urban remote sensing

Book description: One of the key geographical developments over the last two centuries has been that of urbanisation. In recent years this has exploded globally, particularly in developing countries. It is essential for governments, planners and researchers in geography and allied fields to understand this process and the main way of being able to do this is to accurately map these changes. The main method of this mapping is Remote Sensing. This up-to-date analysis of the area looks at a wide range of methodologies currently being used to produce and analyse remotely sensed data of urban areas. The authors examine the various techniques used to extract information from digital, multispectral images of urban areas. Donnay and Barnsley then go on to look at the identification of urban forms, the delineation of agglomerations and the development of urban morphology, considering the analysis of integrated data sets and surface models and going on to look at the estimation of human population levels.
Recent advances in cancer cell bionic nanoparticles for tumour therapy

Abstract Nanoparticle-based drug delivery systems have found extensive use in delivering oncology therapeutics; however, some delivery vehicles still exhibit rapid immune clearance, lack of biocompatibility and insufficient targeting. In recent years, bionanoparticles constructed from tumour cell membranes have gained momentum as tumour-targeting therapeutic agents. Cancer cell membrane-coated nanoparticles (CCMCNPs) typically consist of a drug-loaded nanoparticle core coated with cancer cell membrane. CCMCNPs retain homologous tumour cell surface antigens, receptors and proteins, and it has been shown that the modified nanoparticles exhibit better homologous targeting, immune escape and biocompatibility. CCMCNPs are now widely used in a variety of cancer treatments, including photothermal, photodynamic and sonodynamic therapies, chemotherapy, immunotherapy, chemodynamical therapy or other combination therapies. This article presents different therapeutic approaches using multimodal antitumour therapy—combination of two or more therapies that treat tumours synergistically—based on tumour cell membrane systems. The advantages of CCMCNPs in different cancer treatments in recent years are summarised, thus, providing new strategies for cancer treatment research.