Miracle-dz/UniFAR-FTUs huggingface dataset:
AN IMMUNOTHERAPY TRIO IN ADVANCED FOR COORDINATED

Background The majority of JAK2V617F-negative myeloproliferative neoplasms (MPN) have disease-initiating frameshift mutations in calreticulin (CALR) resulting in a common novel C-terminal mutant fragment (CALRMUT), We found that heteroclitic CALRMUT peptides specifically designed for CALRMUT MPN patient MHC-I alleles efficiently elicited a cross-reactive CD8+ T cell response in human PBMC samples otherwise unable to respond to the matched weakly immunogenic CALRMUT native peptides. We also modeled this effect in mice and observed that C57BL/6J mice, which are unable to mount an immune response to the human CALRMUT fragment, can mount a cross-reactive CD8 + T cell response against a CALRMUT-derived peptide upon heteroclitic peptide immunization and this was further ampli-fied by combining the heteroclitic peptide vaccine with blockade of the immune checkpoint molecule PD-1.
Training and Development: Role of Organized Retail Organization in Bridging the Skill Gap

An organization can achieve the competitive advantage by regularly upgrading the workforce skills. Training and development cater to the need of enhancing the employee skill and is one of the most important tasks that the organization can engage. Unlike any service sector organized retail industry operates in a dynamic environment. The changing customer demand, opening up of markets, technological developments and ever increasing competition, all affect the retail business. Training is an important aspect of human resource management in retail, where training need arises as a result of inducting new employees and skill building of existing workforce. To improve employees‘ skills, organizations must invest in their training. Skilled Manpower is an issue each industry in India is struggling with and retail remains no exception. This paper will explore how retailers are redressing this issue particularly imparting training and development programs fostering learning at various Managerial and non-managerial levels. Also using the qualitative data, this paper will attempt to analyze the kind of the training methods adopted by some of the best organized retailers keeping in view the training need assessment of the employees.
FINITE ELEMENT METHOD APPLIED TO THE ANALYSIS OF MEMS AS TEMPERATURE SENSORS

Micro-electromechanical systems (MEMS) are related to devices that have been used as sensors and actuators in different applications. The increasing importance of this subject is due to the possibility of producing small mechanical and electromechanical devices providing a better performance of some microscopic applications with low cost when compared to classical devices. In this regard, there are different examples related to informatics, telecommunications, and automobile industry, providing the miniaturization of classical devices and also the development of new devices and tools. Pressure, temperature, vibration and acoustics are some of the variables usually monitored by MEMS sensors. This contribution discusses the application of MEMS as temperature sensors. Micromechanical resonant sensor using a beam as a sensitive element is investigated exploring the temperature dependence of the first resonance frequency. Finite element method is employed in order to evaluate the influence of dissipation in the general measurements.
Endocytic control of tumor suppression in Drosophila melanogaster

2 Introduction 3 Drosophila tumor suppressors 3 Lethal Giant Larvae, Discs Large and Scribble 3 Tumor suppressors screens 4 Endocytic genes involved in tumor suppression 4 Aim 5 Chapter I: Endocytosis 6 1. Initial internalization 6 2. Early endosomes 6 3. Recycling 7 4. Multivesicular body sorting 8 5. Lysosomal degradation 8 Chapter II: Cell growth signaling pathways 9 1. EGFR signaling 9 2. Signaling induced by the morphogens Dpp and Wg 10 3. Notch signaling 11 4. Jak/STAT signaling 12 Chapter III: Asymmetric cell division 13 1. Asymmetric endocytosis controls Notch signaling 13 2. Delta activation by Neutralized-controlled endocytosis 14 3. Numb driving asymmetric endocytosis 14 4. Numb and tumor formation 15 Chapter IV: Cell polarity and endocytosis 16 1. Par and Cdc42: a link between vesicle traffic and polarity 16 2. Cell junctions 17 3. Crumbs and apical identity 18 Discussion 19 References 21
A NEW ONE-STEP METHOD FOR THE HISTOCHEMISTRY AND CYTOCHEMISTRY OF CA2+-ATPASE ACTIVITY1

A new one-step lead citrate method is introduced for the histochemical and cytochemical demonstration of Ca2+-ATPase activity. The standard incubation medium contains 3 mM ATP as the substrate, 10 mM CaCl2 as the activator, 2 mM lead citrate as the capture reagent, and 250 mM glycine-NaOH or-KOH buffer, pH 9.0. The incubation medium was clear and stable. Cytochemical reactions in this incubation medium were examined in various tissues; liver, kidney, heart, small intestine, trachea, bone marrow, and femoral muscle. The reaction products were found in plasma membrane, mitochondria, myofilaments, axoneme of cilia, sarcoplasmic reticulum, transverse tubules, gap junctions, lysosomes, and others. The cytochemical reaction showed Ca2+ and substrate dependency. Preheating sections in boiling water resulted in complete loss of the reaction, but pretreatment with 10 mM EDTA or EGTA did not affect it. Inhibitors such as 10 mM PCMB, 0.1 mM quercetin, and 0.1 mM oligomycin, partly reduced the cytochemical reaction in some tissues, but 0.5 mM bromotetramisole left it unchanged. Substrate specificity was proved by the substitution of various substrates. Reaction products were found to be composed of lead phosphate with X-ray microanalysis. From these results, it was concluded that the cytochemical demonstration of Ca2+-ATPase activity was successful by this method at both light and electron microscopic levels.
An alternative approach of competitiveness evaluation for real estate developers

This paper presents a fuzzy competitiveness rating (FCR) method for measuring the competitiveness of real estate developers with referring to the Chinese real estate industry. Research data used for analysis were collected from a case study in Green Town Company. Research into the assessment of real estate developers’ competitiveness has been limited. The fuzzy competitiveness rating method is proposed as an alternative effective approach in assessing the competitiveness of real estate developers. The FCR method furnishes real estate developers with innovative solution to assess their competitiveness. By understanding properly organizational competitiveness, real estate developers can adopt appropriate actions and strategies to utilize organization resources more effectively to enhance their competitiveness, thus improve their business performance in the real estate market.
Nonlinear damping in an energy harvesting device

Energy harvesting from ambient vibration has attracted significant attention in recent years. Some interesting applications include low-power wireless sensors, harvesting power from human motion and large-scale energy harvesters. In order to increase the frequency range of the excitation amplitude over which the vibration energy harvester operates, various nonlinear arrangements have been suggested, particularly using nonlinear springs [1-5]. In contrast, it has recently been shown that the dynamic range of a vibration energy harvester can be increased using a nonlinear damper [5]. Nonlinear damping, particularly stiction, can, however, also be an unwanted problem in practical power harvesters. However, this paper considers the effect of stiction, as Coulomb damping, on the performance of such a vibration power harvester. A mechanical single degree-of-freedom nonlinear oscillator is considered, subjected to a harmonic base excitation. The relative displacement and the average harvested power are obtained for different sinusoidal base excitation amplitudes and frequencies, both analytically and numerically. The performance of the nonlinear harvester at different excitation levels is compared with a linear harvester, which has the same maximum relative displacement at resonance when driven at maximum amplitude. It is demonstrated that the nonlinear harvester can harvest much more energy, compared to the linear one, when driven below its amplitude threshold [5]. The effect of Coulomb damping, as a source of loss, is also investigated, for the harvesters with a linear damping and a cubic damping. It is shown that the Coulomb damping can reduce the amount of the harvested energy, particularly at low excitation amplitudes.
Arrestin/Clathrin Interaction LOCALIZATION OF THE ARRESTIN BINDING LOCUS TO THE CLATHRIN TERMINAL DOMAIN*

Previously we demonstrated that nonvisual arrestins exhibit a high affinity interaction with clathrin, consistent with an adaptor function in the internalization of G protein-coupled receptors (Goodman, O. B., Jr., Krupnick, J. G., Santini, F., Gurevich, V. V., Penn, R. B., Gagnon, A. W., Keen, J. H., and Benovic, J. L. (1996) Nature 383, 447–450). In this report we show that a short sequence of highly conserved residues within the globular clathrin terminal domain is responsible for arrestin binding. Limited proteolysis of clathrin cages results in the release of terminal domains and concomitant abrogation of arrestin binding. The nonvisual arrestins, b-arrestin and arrestin3, but not visual arrestin, bind specifically to a glutathione S-transferase-clathrin terminal domain fusion protein. Deletion analysis and alanine scanning mutagenesis localize the binding site to residues 89–100 of the clathrin heavy chain and indicate that residues 1–100 can function as an independent arrestin binding domain. Site-directed mutagenesis identifies an invariant glutamine (Glu-89) and two highly conserved lysines (Lys-96 and Lys-98) as residues critical for arrestin binding, complementing hydrophobic and acidic residues in arrestin3 which have been implicated in clathrin binding (Krupnick, J. G., Goodman, O. B., Jr., Keen, J. H., and Benovic, J. L. (1997) J. Biol. Chem. 272, 15011–15016). Despite exhibiting high affinity clathrin binding, arrestins do not induce coat assembly. The terminal domain is oriented toward the plasma membrane in coated pits, and its binding of both arrestins and AP-2 suggests that this domain is the anchor responsible for adaptor-receptor recruitment to the coated pit.
Chemical Character of Detrital Garnet in Cauvery River Sediment and Its Provenance, South India

: The study attempts to determine the chemical characters of detrital garnets provenance in the Cauvery River Basin. The geochemical results reveal that the detrital garnets are derived from biotite schist, charnockite, and gneisses of intermediate felsic, moderate to strong weathered provenance. The end member composition of the garnets indicates almandine species that are metamorphosed in amphibolite to granulite facies P-T conditions. The angular outline of detrital garnet in the upstream and sub-rounded to rounded grains in the downstream attribute it’s transport from the upstream of the Cauvery River.
A Novel Chebyshev Series Fed Linear Array with High Gain and Low Sidelobe Level for WLAN Outdoor Systems

This paper proposes a novel high gain and low sidelobe level (SLL) linear microstrip array antenna for outdoor WLAN applications. The antenna consists of two main parts, which are a linear array and a reflector. The linear array comprises of 10 elements; those have been designed on Rogers RT/Duroid 5870tm with the dimensions of 422×100×10.15 mm3. To gain low SLLs, a series fed network was designed to have the output signals being proportional to the Chebyshev distributions (with preset SLL of -30 dB). Furthermore, Yagi antenna theory has been applied by adding directors above every single element to increase the directivity of the single element. The reflector has been constructed at the back of the proposed structure. Simulation results show that the array can provide high gain of 17.5 dBi and a low SLL of -26 dB. A prototype has been fabricated and measured. Good agreements between simulation and measurement data have been obtained.
Mid-Infrared Spectral Assessment of Early-type Galaxies with Star Formation

Abstract Mid-infrared (mid-IR) spectra from ~5 to 14 μm of five, nearby (< 70 Mpc) elliptical galaxies are presented that were observed with the Infrared Spectrograph on the Spitzer Space Telescope. The sample galaxies have a main stellar component that is typical for normal, passively evolving ellipticals; however, they are rich in cold gas and dust and have morphological-merger signatures from which a time order of the galaxies since the merger or accretion events can be estimated. The presented results are significant because (1) emission due to Polycyclic Aromatic Hydrocarbons (PAHs) and associated species is detected for the first time in these galaxies and (2) the detected mid-IR spectra are independently exploited as a probe of current or recent star-formation that, in this case, is assumed to be triggered by the merger. As shown in exemplary spectra of the early-age merger NGC 3656, the strength of the PAH emission is more centrally peaked in the earlier-age mergers, suggesting that the PAH data are indeed probing star-formation that is correlated with the time since the mergers and systematically depletes the centrally located gas, becoming weaker and more flatly distributed as the merger evolves.
Southern Ocean mesocyclones and polar lows from manually tracked satellite mosaics

A new reference data set of mesocyclone activity over the Southern Ocean has been developed from the manual analysis of high‐resolution infrared satellite mosaics for winter 2004. Of the total 1735 mesocyclones which were identified and analyzed, about three quarters were classified as being “polar lows” (i.e., intense systems; see Rasmussen and Turner, 2003). The data set includes mesocyclone track, size, associated cloud vortex type, and background synoptic conditions. Maxima in track density were observed over the Bellingshausen Sea and around East Antarctica and are highly correlated with cyclogenesis regions. A comparison against QuikSCAT and reanalyses wind characteristics shows that the reanalyses, while capturing mesocyclone events, tend to considerably underestimate their wind speed (by up to 10 m s−1). This mesocyclone data set is available as a reference for further analysis of mesocyclones and for the evaluation and development of cyclone‐tracking algorithms.
The Research on EHA Based Aircraft Braking System and Its Nonlinear Control

An Electro-hydrostatic actuator (EHA) structure with joint of pump control and valve control is proposed for more electric aircraft (MEA) braking system, the working principle of the system is analyzed, and on the basis of that, the mathematical models of the system components are established. To compromise the problem of pressure overshoot and dynamic characteristics with the conventional PID control method, and to prevent wheels from mistakenly locking which resulting in decreased brake efficiency, a fuzzy PID pressure controller is designed. Through simulation test, the rated pressure step response time of the system is about 0.35 s with 2 percent overshoot and 0.05 MPa steady-state error, the system -3 dB bandwidth is 8 Hz. It is demonstrated that the structure is feasible, the controller design is reasonable, and the EHA can satisfy the requirements of the aircraft braking system in static and dynamic performance. Keywords-aircraft braking system; electro-hydrostatic actuator; antiskid control; fuzzy PID control
Success Catalyst or Hidden Impediment? The Moderating role of Governance Power of Top Management Teams in the Strategic Process

Although the literature on strategy formulation or implementation has been accumulating, whether to keep strategy stable so as to maximize firm performance has not yet been conclusively determined, particularly when the strategy-making process is intertwined with different levels of top management teamâ€™s (TMT) governance power. This study is an attempt to revisit the performance implication of strategic persistence from the contingency perspective, which argues that such a relationship is sensitive to TMT power status. TMT power is characterized as ownership power structural power. Our evidence, in a sample of Taiwanese firms, lends support to the positive moderating effects of these two dimensions of governance power on the elusive relationship between strategic persistence and firm performance, while the deviation from the two dimensions weakens firm performance. This study demonstrates the critical role of top managers in the strategic process, and cautions against drawing universalistic normative implications for governance arrangement of TMT.
A Survey on Securing the Virtual Machines in Cloud Computing

Cloud computing is one of today’s most exciting technologies, because it can reduce the cost and complexity of applications, and it is flexible and scalable. These benefits changed cloud computing from a dreamy idea into one of the fastest growing technologies today. Virtualization is a rapidly evolving technology that can be used to provide a range of benefits to computing systems, including improved resource utilization, software portability, and reliability. In addition, the virtualization technology has limit security capabilities in order to secure wide area environment such as the cloud. Therefore, the development of a robust security system requires changes in traditional virtualization architecture. This paper discusses virtualization components, approaches , VMs Encryption options and new security architecture in a hypervisor-based virtualization technology in order to secure the cloud environment. Keywords—Virtualization, cloud computing, security, hypervisor.
Activity of Lepidium meyenii Walp (purple maca) in immunosuppressed Oryctolagus cuniculus (albino rabbits)

Various properties are attributed to “maca”, including immunomodulatory properties due to its secondary metabolites such as macamides, glucosinolates, isothiocyanates and flavonoids. Immunosuppression, hemolytic anemia, and thymic involution were induced with cyclophosphamide. Three concentrations of doses of dehydrated hydroalcoholic extract of purple maca (EHADM) were used for 30 days, the analysis of variance and Duncan’s multiple comparisons test the results are statistically significant (p<.05) which shows immunostimulatory activity in the marrow bone (monocytes, lymphocytes and white blood cells) and antianemic (hematocrit 31%) compared to the negative control group (G-1). At 84 mg/kg and at 167 mg/kg, it shows immunomodulatory activity on the humoral response in 66.70% of the experimental animals (G-3 and G-4). It is concluded that the dehydrated hydroalcoholic extract of purple maca presents immunostimulating and immunomodulatory activity on the humoral response in 66.7% of the Oryctolagus cuniculus induced to immunodeficiency with cyclophosphamide.
Supply Function Equilibria in Oligopoly under Uncertainty

The authors model an oligopoly facing uncertain demand where each firm chooses as its strategy a "supply function" relating its quantity to its price. A supply function adapts better to an uncertain environment than either a fixed price or a fixed quantity; it could be committed to through the choice of organizational structure and employee decision rules. The authors give conditions for existence and for uniqueness of a Nash equilibrium in supply functions under uncertainty. They compare the equilibrium with the Cournot and Bertrand equilibria as they vary the demand and cost curves, the number of firms, and the form of uncertainty. Copyright 1989 by The Econometric Society.
1 Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb 1 Running title : Mammalian Elongin A complex ubiquitylates Rpb

Department of Functional Genomics, Kochi Medical School, Kohasu, Oko-cho, Nankoku City, Kochi 783-8505, Japan; Division of Biological Science, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya City, Aichi 464-8602, Japan; Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA; and Department of Biochemistry and Molecular Biology, Kansas University Medical Center, Kansas City, Kansas 66160, USA
An observational study of the precedence effect

This paper proposes a framework model for the analysis of sound source localisation under the precedence effect using Gaussian mixtures. The model quantifies the effect of the lagging sound over the angular position and the width of the perceived auditory event, and incorporates some well-known aspects of the precedence effect in a single framework. Two sound source localisation experiments were carried out in order to show the utility of the proposed model. In the first experiment, the localisation accuracy for single sound sources was measured. In the second experiment, the subjects localised spectrally coherent lead-lag stimulus pairs with different angular separations. The responses were analysed using the proposed model. It is shown that the model can be used for assessing the fusion, localisation dominance, and the lag discrimination suppression aspects of the precedence effect as well as the associated widening of the auditory event.
Positively Deviant: New Evidence for the Beneficial Capital of Maverickism to Organizations

Workplace mavericks are seen as highly disruptive, engaging in unconventional behavior and showing apparent disregard for organizational norms, policies, and procedures. Despite this, some organizational leaders successfully leverage maverick behaviors to progress and achieve higher order organizational agendas. This paper challenges the former view by investigating the positive value maverickism provides organizations. Guided by the conceptualization of mavericks’ non-conformity as a form of positive deviance, two studies were conducted. Study 1 analyzed secondary data sources within the scientific research field to determine organizational performance requirements and expectations. Study 2 interviewed 28 mavericks and 27 leaders of mavericks in the same field. Data collection and analysis was guided by Bourdieu’s (1990) theoretical and methodological constructs—field, capital, and habitus. Results highlight that, while mavericks challenge and often ignore many organizational norms, their disruption is driven by the desire to achieve higher order goals benefitting their organizations and communities. Operating within boundaries set by these higher order values, mavericks not only embody traditional cultural capitals expected in their field but also offer valuable capitals traditionally possessed by those more senior in the field. This powerful combination of capitals produces additional symbolic capital which allows them to influence organizational decision-making despite not conforming to lower order organizational norms. At an applied level, valuable capitals associated with maverickism can be leveraged by leaders to support transformational change. To do this, organizational leaders need to recognize mavericks’ strengths through allowing them, as positive deviants, to challenge the status quo and to find alternative pathways to achieve organizational goals.