Miracle-dz/UniFAR-FTUs huggingface dataset:
Data profile: The Statistics Canada Biobank.

Introduction The Statistics Canada Biobank (Biobank) is a valuable source of nationally representative health information. It contains biospecimens collected from the Canadian Health Measures Survey (CHMS) and the Canadian COVID-19 Antibody and Health Survey (CCAHS). Both surveys are voluntary and aim to collect a variety of important health information from Canadians to create nationally representative estimates. This information is collected through questionnaires, physical measures, and self-administered sample collection. Biospecimens collected as part of the CHMS and CCAHS from consenting participants include whole blood, plasma, serum, urine, DNA samples, and dried blood spots. These samples are stored as part of the Biobank for future health research. Canadian researchers can apply to the Biobank program to use this nationally representative source of biospecimens. Results obtained from their research can also be combined with a wide variety of health and lifestyle information collected as part of the CHMS and CCAHS, making the Biobank a rich source of health-related information that can fill data gaps on the health concerns that are important to Canadians. This data resource profile provides an overview of the Biobank to inform researchers and data users about the program and how it can be used as a resource for the advancement of health-related research.
Skin biopsy reveals generalized small fibre neuropathy in hypermobile Ehlers–Danlos syndromes

Ehlers–Danlos syndromes are hereditary disorders of connective tissue that are characterized by joint hypermobility, skin hyperextensibility and tissue fragility. The most common subtype is the hypermobile type. In addition to symptoms of small fibre neuropathy (SFN) due to damage to the small peripheral nerve fibres, with degeneration of the distal nerve endings, autonomic disorders such as postural tachycardia syndrome (PoTS) are frequently reported features in patients with hypermobile Ehlers–Danlos syndrome (hEDS). To date, the underlying pathophysiological mechanisms are still not completely understood.
Apparent randomness is not always the complement of apparent order.

We asked 124 subjects to simulate a series of 240 tosses of a fair coin. Multiple regression analyses revealed that sequence generation is constrained by run length, the frequency of alternation, and the imbalance between heads and tails. Subjects did not avoid patterned or symmetric subsequences. These results are discussed in terms of the way subjects view the history of prior responses as they form future responses.
Damping of Flexural Waves by a Constrained Viscoelastic Layer

For a number of years it has been known that flexural vibrations in a plate can be damped by the application of a layer of damping (viscoelastic) material that is in turn constrained by a backing layer or foil. A common example is the damping tape currently used in aircraft.This paper presents a quantitative analysis of the damping effectiveness of such a constrained layer. As in the work of H. Oberst the damping is characterized by the loss factor η, which is the normalized imaginary part of the complex bending stiffness of the damped plate.The calculated damping factor depends on the wavelength of bending waves in the damped plate, and on the thicknesses and elastic moduli of the plate, the damping layer, and the constraining layer. A complex shear modulus is assigned to the damping layer, where all of the energy dissipation is assumed to take place.Damping factors have been determined experimentally on laboratory test bars for a number of constrained‐damping‐layer applications for frequencies from abou.
Placebo Response and Media Attention in Randomized Clinical Trials Assessing Cannabis-Based Therapies for Pain

Key Points Question What is the size of the placebo response in cannabinoid trials for clinical pain, and is the magnitude of placebo response associated with media attention on the trials? Findings This meta-analysis of 20 studies of 1459 individuals found a significant pain reduction in response to placebo in cannabinoid randomized clinical trials. Media attention was proportionally high, with a strong positive bias, yet not associated with the clinical outcomes. Meaning These findings suggest that placebo has a significant association with pain reduction as seen in cannabinoid clinical trials, and the positive media attention may shape placebo responses in future trials.
Inclusive Care Practices and Policies Among Sexual and Gender Minority Older Adults.

As the health care and well-being of sexual and gender minority (SGM; i.e., lesbian, gay, bisexual, and/or transgender or gender non-binary) people in the United States receive federal and local-level attention, SGM older adults and caregivers continue to be left out of important health policy and care conversations. The current article describes policy issues and affirmative strategies related to inclusive care practices among SGM older adults and caregivers. In addition to the broader policies considered related to health and well-being, we include a discussion of local-level policy strategies to mitigate discrimination and promote inclusive care for SGM older adults and caregivers. [Journal of Gerontological Nursing, 48(12), 6-15. ].
Potential relevance of a motor skill “proficiency barrier” on health-related fitness in youth

ABSTRACT This study investigated the potential impact of a motor skill proficiency barrier on measures of cardiorespiratory (CRF) and musculoskeletal (MSF) fitness in youth. A sample of 241 youth (114 girls) aged 10 - 18 years, completed the Motor Competence Assessment battery with composite scores indexed according to age- and gender-adjusted percentile scores. Motor competence (MC) levels were categorized as low (≤ 25%tile – proficiency barrier), moderate (≥ 26%tile to < 75%tile), and high (≥ 75%tile). CRF levels (Health Risk, Needs Improvement, and Healthy) were assessed using the Fitnessgram® 20 m PACER test. Low (≤ 20%tile), moderate (≥ 21%tile to ≤ 80%tile), and high (≥ 80%tile) MSF levels were assessed using grip strength normative data. Two 3 × 3 chi-square tests were conducted to determine the probability of MC level predicting CRF and MSF levels. Results demonstrated statistically significant models for performance on both the PACER (χ2[4, N = 241] = 22.65, p < .001) and grip strength (χ2[4, N = 241] = 23.95, p < .001). Strong evidence of a proficiency barrier impacting CRF was noted, as no low skilled youth met the “Healthy” fitness zone standards for PACER performance. Evidence supporting a barrier with grip strength was not as strong, as 20.8% of youth exhibiting low MC displayed high grip strength. However, all individuals with high levels of MC demonstrated at least moderate grip strength. Results emphasize the importance of developing MC during childhood as it may provide a protective effect against unhealthy CRF and MSF across youth. Highlights These data support the notion of Seefeldt’s (1980) proficiency barrier as it relates to CRF, as no youth demonstrating low MC met the healthy fitness zone criteria for PACER performance. The development of MC may both directly and indirectly provide a protective effect against unhealthy CRF levels across childhood and adolescence. Evidence supporting a proficiency barrier with MSF as measured by grip strength was not as strong; however, all individuals with high levels of MC demonstrated at least moderate grip strength. Thus, the development of MC may be a protective factor to mitigate low levels of MSF via enhanced neuromuscular function. Promoting the development of MC in a variety of developmentally appropriate activities and settings (e.g. MC skills practice, structured and unstructured play, and performance contexts) is important to promote positive trajectories of CRF and MSF across childhood and adolescence.
Commuting Elements in Q-Deformed Heisenberg Algebras

Immediate consequences of the commutation relations bases and normal form in H(q) and H(q,J) degree in and gradation of H(q,J) centralisers of elements in H(q,J) centralisers of elements in H(q) algebraic dependence of commuting elements in H(q) and H(q,J) representations of H(q,J) by q-difference operators the diamond lemma degree functions and gradations q-special combinatorics.
Engineered potentials and dynamics of ultracold quantum gases under the microscope

Abstract : In this thesis, I present experiments on making and probing strongly correlated gases of ultracold atoms in an optical lattice with engineered potentials and dynamics. The quantum gas microscope first developed in our lab enables single-site resolution imaging and manipulation of atoms in a two-dimensional lattice, offering an ideal platform for quantum simulation of condensed matter systems. Here we demonstrate our abilities to generate optical potential with high precision and high resolution, and engineer coherent dynamics using photon assisted tunneling. We also create a system of bilayer quantum gases that brings new imaging capabilities and extends the possible range of our quantum simulation. To engineer precise optical potentials, we tackle uncontrolled disorder using in- coherent light sources and Fourier filtering of lattice beams. We develop a spatially incoherent light source which suppresses disorder caused by defects and scattering in the imaging system. Digital micro-mirror devices are used as spatial light modulators to shape arbitrary potentials with single site resolution. Next we study photon-assisted tunneling as an example of driven coherent dynamics. We observe sharp, interaction-shifted photon-assisted tunneling resonances, and resolve the multi-orbital shifts. Using photon-assisted tunneling, we drive a quantum phase transition between a paramagnet and an anti-ferromagnet, and observe quench dynamics at a critical point. We prepare tunnel-coupled bilayer systems, and use interaction blockade to engineer occupation-dependent inter-plane transport. The site resolved imaging of the bilayer system allows us to circumvent the limitations of parity imaging to directly observe the Mott insulator \wedding cake structure and density ordering in the anti-ferromagnetic state, and to perform spin-resolved readout of a hyperfine mixture.
Update on new treatments for rare ovarian tumours

Purpose of review In spite of their rarity when considered individually, the sum of all rare ovarian tumours (ROT) represent almost half of all ovarian malignancies. As such, their appropriate inclusion within dedicated clinical trials is essential for enhanced management. Recent findings Supported by institutional expert national (e.g. TMRG) and international (e.g. ESGO) networks and owing to national (e.g. ARCAGY-GINECO) and international (e.g. ENGOT) collaborations dedicated to clinical research, the last few years have shown increased number of clinical trials dedicated to ROT. These either were based on specific molecular features of ROT (e.g. expression of oestrogen receptors for low-grade serous ovarian carcinomas and anastrazole evaluation in the PARAGON trial) or on the evaluation of innovative therapies (e.g. pembrolizumab within the ROT cohort from the AcSé Pembrolizumab multicentric basket trial). Furthermore, recent years have also shown the advent of randomized clinical trials. For instance, the ALIENOR trial positioned weekly paclitaxel as a new option for relapsed sex cord-stromal tumours, while the GOG281/LOGS trial raised trametinib as a new standard-of-care option for recurrent low-grade serous carcinomas. Summary The last few years have exhibited a paradigm shift towards the possibility to develop dedicated trials for ROT, owing to international collaborations supported by institutional networks. Current trials, molecular-driven and based on innovative designs, are highly promising, as they may bring ROT management towards more personalized medicine.
Innovative approaches in transforming microRNAs into therapeutic tools

MicroRNA (miRNA) is regarded as a prominent genetic regulator, as it can fine‐tune an entire biological pathway by targeting multiple target genes. This characteristic makes miRNAs promising therapeutic tools to reinstate cell functions that are disrupted as a consequence of diseases. Currently, miRNA replacement by miRNA mimics and miRNA inhibition by anti‐miRNA oligonucleotides are the main approaches to utilizing miRNA molecules for therapeutic purposes. Nevertheless, miRNA‐based therapeutics are hampered by major issues such as off‐target effects, immunogenicity, and uncertain delivery platforms. Over the past few decades, several innovative approaches have been established to minimize off‐target effects, reduce immunostimulation, and provide efficient transfer to the target cells in which these molecules exert their function. Recent achievements have led to the testing of miRNA‐based drugs in clinical trials, and these molecules may become next‐generation therapeutics for medical intervention. Despite the achievement of exciting milestones, the dosage of miRNA administration remains unclear, and ways to address this issue are proposed. Elucidating the current status of the main factors of therapeutic miRNA would allow further developments and innovations to achieve safe therapeutic tools.
Torsional Alfvén Waves As Pseudo‐Magnetic Flux Ropes

We examined two classes of the solar wind magnetic field variations which show well‐ordered smooth rotations with time scales of 2–7 hours. In one class, the solar wind velocity changes in good correlation with the rotating magnetic field. It is shown that the torsional Alfven wave model can explain the observed variations in this class. In another class, no significant correlation is seen between the magnetic field and the velocity. This class is interpreted by a flux rope model and taken as a small‐scale magnetic flux rope. It is also shown that the observed magnetic field variations in the first class could be easily mistaken as small‐scale magnetic flux ropes, if a careful analysis was not undertaken. The present study provides a baseline to distinguish the above two classes of rotational variations in the solar wind magnetic field.
On the Origin of Planetary Nebulae

A hypothesis that planetary nebulae originate from red giants when tl:e helium burning begins in the degenerate helium core is proposed and examined quantitatively. It is assumed that the shock wave is generated by the rapid core expansion which is caused by the removal of degeneracy at the helium core. The propagation of the shock wave is analysed by the quasi-stationary method. The obtained expansion velocity and thrown mass are 95 kmjsec . and 0.5M® respectively. A relation between remnant stars and nuc.lei of planetary nebulae is also discussed briefly. § 1. lnt1rodution The evolution of the stable stars has been· investigated widely, especially nowadays, with the aid of high speed electronic computers, and it has been made clear how the stable stars evolve at least from the main sequence to red giant for various masses. Nevertheless, as for the unstable stars, for example, novae or planetary nebulae, etc., from what stage of evolution they originate remains open. It is necessary, thus, to investigate the origin and evolution of unstable stars on the basis of calculated models of stable stars. In this note, a hypothesis that planetary nebulae originate from red giant stars when the helium burning begins in a degenerate. helium core is proposed and examined. § 2. Quantitative investigations on the proposed hypothesis A characteristic feature in initial phases of helium burning in the degenerate core is that owing to the high degeneracy it goes on with rising of the temper­ ature but without the expansion of the gas untill the core becomes non-degenerate.
Accidente isquémico y ¿transitorio? Resonancia magnética en el AIT: experiencia de 106 casos

Introducción. El accidente isquémico transitorio (AIT) clásicamente se ha definido como un episodio de déficit focal neurológico autolimitado con duración máxima de 24 horas, sin evidencia en la neuroimagen de lesión isquémica aguda establecida. Sin embargo, la definición de esta entidad está variando y se está adaptando a los nuevos tiempos y técnicas diagnósticas, incluida la resonancia magnética (RM) con secuencias en difusión. Es importante un abordaje íntegro y precoz del AIT, con RM cerebral, para descartar ictus isquémicos establecidos recuperados clínicamente, y así optimizar el manejo diagnóstico y terapéutico de los pacientes. Pacientes y métodos. Se identificó a los pacientes ingresados en un período de seis meses como sospecha de AIT en nuestra unidad de ictus, y se estudió el diagnóstico definitivo y su abordaje basándose en las pruebas realizadas. Resultados. Se estudiaron 106 sospechas de AIT en las que se realizó una RM precoz. De ellas, 43 (40,57%) fueron ictus isquémicos clínicamente recuperados (IICR); 31 (29,24%), otras patologías (nueve trastornos funcionales, seis crisis epilépticas, cinco auras migrañosas, dos amyloid spells y nueve otras causas); 26 (24,52%), AIT; y seis (5,66%), ictus hemorrágicos. De 43 IICR, ocho (18,6%) fueron cardioembólicos; ocho (18,6%), aterotrombóticos; ocho (18,6%), ictus embólico de origen desconocido; seis (13,95%), lacunares; cinco (11,62%) de causa infrecuente; cuatro (9,3%) microangiopáticos y cuatro (9,3%), de causa indeterminada. Los IICR recibieron un manejo terapéutico significativamente más individualizado respecto a los pacientes con AIT. Conclusiones. El uso de RM precoz en la sospecha clínica de AIT permite evidenciar la existencia de IICR y optimizar el abordaje diagnóstico y terapéutico de los pacientes.
Oral pregabalin is effective as preemptive analgesia in abdominal hysterectomy—A randomized controlled trial

Postoperative pain is one of the main negative symptoms resulting from surgery and the use of new methods to control this symptom is of ever‐increasing relevance. Opioid‐sparing strategies, such as multimodal analgesia, are trends in this scenario. Pregabalin is a well‐established treatment for neuropathic pain; however, it is still controversial in the surgical context for postoperative analgesia. This study investigated the effect of pregabalin on postoperative analgesia in patients undergoing abdominal hysterectomy. It is a prospective, randomised, double‐blind, placebo‐controlled clinical trial. Female patients undergoing abdominal hysterectomy were randomised to use pregabalin (group P1), 300 mg orally 2 h before surgery, or identical placebo pills (group P0). The main outcome includes the postoperative pain index by visual analogue scale (VAS) and McGill's pain questionnaire. Secondary outcomes include opioid consumption and the presence of adverse effects. A value of p < 0.05 was used to reject type I error. Fifty‐five patients were randomised amongst the groups. Patients in group P1 had lower pain rates by VAS scale, both at rest and in active motion, than group P0. In McGill's questionnaire, patients from group P1 also had lower pain rates (12 × 28.5). There was approximately twice as much opioid consumption amongst patients in group P0. Regarding side effects, there was a difference between the two groups only for dizziness, being more incident in group P1. This study suggests that pregabalin is an important adjuvant drug in treating postoperative pain in patients with abdominal hysterectomy.
The effects of electron scattering opacity in the broad emission-line regions of quasars

It is demonstrated that three observational puzzles in quasars, nearly symmetric Lyman-alpha profiles, weakly asymmetric C IV 1549 A, and offsets between the peaks of these high ionization lines and the systematic velocity, can all be explained by the standard model of the physical state of the broad-line region with the addition of the simplest possible kinematics. Electron scattering in the intercloud medium is the essential ingredient that had been previously neglected. It is shown that the profiles depend at least as sensitively on the run of physical conditions as on the velocity law. Approximate analytic representations of the line emissivities based on detailed photoionization models are used to describe that dependence.
ANKRD11 pathogenic variants and 16q24.3 microdeletions share an altered DNA methylation signature in patients with KBG syndrome

Abstract Pathogenic variants in ANKRD11 or microdeletions at 16q24.3 are the cause of KBG syndrome (KBGS), a neurodevelopmental syndrome characterized by intellectual disability, dental and skeletal anomalies, and characteristic facies. The ANKRD11 gene encodes the ankyrin repeat-containing protein 11A transcriptional regulator, which is expressed in the brain and implicated in neural development. Syndromic conditions caused by pathogenic variants in epigenetic regulatory genes show unique patterns of DNA methylation (DNAm) in peripheral blood, termed DNAm signatures. Given ANKRD11’s role in chromatin modification, we tested whether pathogenic ANKRD11 variants underlying KBGS are associated with a DNAm signature. We profiled whole-blood DNAm in 21 individuals with ANKRD11 variants, 2 individuals with microdeletions at 16q24.3 and 28 typically developing individuals, using Illumina’s Infinium EPIC array. We identified 95 differentially methylated CpG sites that distinguished individuals with KBGS and pathogenic variants in ANKRD11 (n = 14) from typically developing controls (n = 28). This DNAm signature was then validated in an independent cohort of seven individuals with KBGS and pathogenic ANKRD11 variants. We generated a machine learning model from the KBGS DNAm signature and classified the DNAm profiles of four individuals with variants of uncertain significance (VUS) in ANKRD11. We identified an intermediate classification score for an inherited missense variant transmitted from a clinically unaffected mother to her affected child. In conclusion, we show that the DNAm profiles of two individuals with 16q24.3 microdeletions were indistinguishable from the DNAm profiles of individuals with pathogenic variants in ANKRD11, and we demonstrate the diagnostic utility of the new KBGS signature by classifying the DNAm profiles of individuals with VUS in ANKRD11.
Stimulated Raman scattering in solid hydrogen: Measurement of coherence decay

Stimulated Raman scattering (SRS) is experimentally investigated for solid hydrogen in the context of the strong coupling. Coherence decay behaviors are measured for the Raman transition of $Q(0)$ $(\ensuremath{\nu}=1\ensuremath{-}0)$ using the time-resolved coherent anti-Stokes Raman-scattering method. We show that the coherence decay for the Raman transition changes with the evolution of the SRS from the weak-coupling regime to the strong-coupling regime.
Health economic outcomes of switching to alemtuzumab from other disease-modifying therapies in people with multiple sclerosis in the USA

Aim Describe demographics, clinical characteristics, healthcare resource utilization (HCRU) and costs in people with multiple sclerosis (pwMS) switching to alemtuzumab from other disease-modifying therapies (DMTs). Patients & methods Retrospective, observational study of IBM®MarketScan® claims database. PwMS previously treated with DMTs and initiating alemtuzumab (1 January 2013 to 31 December 2019) were identified. “Index” was date of alemtuzumab initiation (prescription filled). Results The study cohort (n = 341) was primarily female (72%) with (mean ± standard deviation) age 45.1 ± 9.5 years. At index, duration of MS was 5.3 ± 2.8 years. HCRU (inpatient/outpatient services), outpatient costs (including MS-specific MRI and emergency room visits) and annualized relapse rate significantly reduced over the 2 years following initiation of alemtuzumab. DMT costs reduced over the same period. Conclusion Health economic and clinical benefits were seen following switching to alemtuzumab from other DMTs for treatment of MS, in this cohort from the USA.