Miracle-dz/UniFAR-FTUs huggingface dataset:
Sero-Prevalence of Malaria among Children's Visit to a Teaching Hospital

Malaria is known to everyone as a serious and major health issue that is transmitted through mosquitoes. Both urban and rural areas are affected by this health problem. The present study was therefore conducted to determine the sero-prevalence of malaria in children visiting Mardan medical complex Mardan, Pakistan. This study was carried out from January 2018 to December 2018 in Mardan medical complex Mardan, Pakistan. Children having age ranging from two months to 15 years were included in the study. All the included children in our study were with signs and symptoms of malaria. 300 samples were collected totally from children of different ages. Thick and thin smears were prepared from the blood of suspected malaria patients. Out of 300 samples, 90 samples (30%) were found to be malaria positive. The species of plasmodium found in our study were P . vivax 54(60%) and P. falciparum 36(40%). While there was no case of mixed infections in our study. Prevalence of malaria among positive cases was higher in male 50 (55.55%) in comparison to female 40(44.44%). In the age group ≥ 5 year’s higher rate of infections was found while the lowest rate of infection was found in the age group 11-15 years. In August, the highest rate (20%) of infections was found while the lowest rate of infection (3.33%) was observed in March. Our study concluded that in district Bannu malaria is the most common public health issue. Both species of plasmodium, P. vivax and P.falciparum were found to have existed in district Bannu. In our study it was concluded that P. vivax is highly prevalent in comparison to P. falciparum. Elimination of poverty, to aware the people about malaria, economic development and to facilitate health adequately are the main factors in district bannu and southern region of Khyber Pakhtunkhwa to eliminate malaria.
Modelling sustainable drainage and decentralised flood mitigation techniques

Assessing the performance of decentralised flood mitigation practices requires novel hydrological modelling approaches that can handle a large number of spatially distributed measures and enables a water redistribution functionality to simulate exceedance flow control. This becomes one of the key tasks of the stormwater management in urban areas considering the present and future conditions mainly driven by climate change and urban growth. A combination of local drainage systems and water retention in public spaces may provide an appropriate strategy to cope with these effects. This paper presents the implementation of a SUDS modelling approach in a semi-distributed hydrological model that enables the simulation of flow among multiple linked SUDS and retention spaces. The objectives of the implemented model are the representation of SUDS as model elements with water redistribution functionality as well as its possible integration into a flood risk management tool. The application of this model is presented for two case studies in Germany. The results show a high potential for SUDS and multipurpose spaces in flood mitigation management.
Danish Chlamydia Study (2018). Pelvic inflammatory disease risk following negative results from chlamydia nucleic acid amplification tests (NAATs) versus non-NAATs in Denmark: A retrospective cohort. (1),

Background Nucleic Acid Amplification Tests (NAATs) are the recommended test type for diagnosing Chlamydia trachomatis (chlamydia). However, less sensitive diagnostic methods—including direct immunofluorescence (IF) and enzyme-linked immunoassay (ELISA)—remain in use in lower resourced settings. We estimate the risk of pelvic inflammatory disease (PID) following undiagnosed infection in women tested with non-NAATs and estimate the health gain from using accurate diagnostic tests.
impacts of withdrawal and replacement of general practitioner services on aeromedical service trends: A 13-year interrupted time-series study in Northern

Background: The Royal Flying Doctor Service (RFDS) provides aeromedical care to patients during fixed-wing transport over vast distances to healthcare unavailable in rural or remote communities. This study examined the relationship between changes in local accessibility to primary healthcare services and rates of aeromedical service use over time. Methods: This was a 13-year interrupted time-series study (1999 – 2012) in Tennant Creek, Northern Territory. Quarterly aeromedical service use for primary care sensitive conditions were calculated and exposure to general practice (GP) services was characterised over time with events modelled as intervention variables: (a) GP service withdrawal (Nov-2004); and (b) GP service replacement (Dec-2006). Intervention effects were estimated using PROC ARIMA in SAS after examination of the time-series structure. Results: GP withdrawal resulted in an immediate and sustained doubling in quarterly aeromedical service use (+11.8 services per quarter) and GP service replacement had no significant effect. Discussion: Large and immediate increases in aeromedical service use result from the loss of local GPservices yet, in this case, replacement with a new GP service, 2-years hence, did not ameliorate that effect after six years. Conclusions: These findings demonstrate the immediate impact of GP-service loss on the rates ofaeromedical transfer of patients from this remote community and lend caution to expectations about thetimeline over which newly implemented primary health care services in such contexts can mitigate the impact of such a loss.
Emergency Management of Acute Ischaemic Stroke Emergency Management of Acute Ischaemic Stroke

Stroke is a medical emergency with ischaemic stroke being the commonest type world- wide. Hypertension has been identified as the leading modifiable risk factor globally. The management of acute ischemic stroke is fast changing due to the advancement in technology and the introduction of intravenous recombinant tissue plasminogen activa -tor. There is a limited time window for early intervention to salvage the ailing neurons. The first 24 hours of presentation is therefore crucial in management. Early recognition of stroke symptoms with rapid intervention can lead to a favourable outcome. Specialized care during the acute phase in the intensive care or stroke unit can improve the overall prognosis.
Development and NKT17 Fate Decision Signaling in Invariant NKT Cell Cutting Edge: Discrete Functions of mTOR

Invariant NKT (iNKT) cells recently were classiﬁed into NKT1, NKT2, and NKT17 lineages with distinct transcription factor and cytokine proﬁles, but the mechanisms underlying such fate decisions remain elusive. In this article, we report crucial roles for mechanistic target of rapamycin (mTOR) signaling, especially mTORC2, in iNKT cell development and fate determination of NKT17 cells. Loss of Rictor, an obligatory component of mTORC2, decreased thymic and peripheral iNKT cells, which was associated with defective survival. Strikingly, Rictor deﬁciency selectively abolished the NKT17 lineage, as indicated by a marked reduction in ROR g t and IL-17 expression. Moreover, deletion of phosphatase and tensin homolog (Pten) upregulated mTORC2 activity and enhanced NKT17 generation, but concomitant loss of Rictor reversed the NKT17 dysregulation. In contrast, mTORC1 regulators Raptor and Rheb are dispensable for NKT17 differentiation, despite their importance in iNKT cell thymic development. Our ﬁndings establish pivotal and unique roles for mTORC2 signaling, which is reciprocally regulated by Rictor and Pten, in NKT17 lineage determination. The Journal of Immunology , 2014, 193: 000–000.
Lipid Profile in Thiazide Induced Hypomagnesemic Rats

Objective : To study the effect of Magnesium supplementation on lipid profile (TC, HDL, LDL, TG, VLDL) and inflammatory markers (CRP s-VCAM 1) in thiazide administered rats. Study Design: Randomized control trial. Place and Duration of Study: Department of Biochemistry & Molecular Biology, Army Medical College Rawalpindi from Feb 2010 to Feb 2011. Material and Methods: Ninety male Sprague Dawley rats, of age 90 to 120 days, divided into three groups: Control, Hydrochlorothiazide (HCTZ) administered control and Hydrochlorothiazide + Magnesium Oxide (HTCZ + Mg2+), administered experimental groups. Levels of inflammatory markers, Magnesium, lipid profile were measured in blood, after three weeks. Results: Mean values in control group were: Serum TG 104.39 mg/dl,TC151.86 mg/dl, HDL76.91 mg/dl, LDL 52.52 mg/dl, VLDL 19.78mg/dl, CRP 1784.27 mg/L, sVCAM-1 564.33ng/ml and serum Magnesium0.85mmol/l. Mean lipid profile values in HCTZ administered control group were Serum TG 150.04 mg/dl, TC 182.92 mg/dl, HDL 71.77 mg/dl, LDL 76.40 mg/dl,VLDL 32.56 mg/dl, CRP 2923.33 mg/L, sVCAM-1 2003.00 ng/ml and serum Magnesium 0.49 mmol/l. Mean lipid profile values in HCTZ + Magnesium administered experimental group were Serum TG 131.69 mg/dl,TC 157.60 mg/dl, HDL 73.55 mg/dl,LDL 58.2 mg/dl,VLDL 25.05mg/dl, CRP 2149.53 mg/L ,sVCAM-1 1516.60 ng/mland serum Magnesium 0.68mmol/l. Conclusion: Levels of sVCAM-1, CRP, TG, TC, LDL and VLDL are increased in HCTZ administered group, with negative correlation with serum magnesium levels. Levels of these parameters decreased in HTCZ + Mg2+ administered group, showing that magnesium supplementation helped in normalizing derangements ( p <0.05).
Accelerating the energy retro ﬁ t of commercial buildings using a database of energy ef ﬁ ciency performance

Small and medium-sized commercial buildings can be retro ﬁ tted to signi ﬁ cantly reduce their energy use, however it is a huge challenge as owners usually lack of the expertise and resources to conduct detailed on-site energy audit to identify and evaluate cost-effective energy technologies. This study presents a DEEP (database of energy ef ﬁ ciency performance) that provides a direct resource for quick retro ﬁ t analysis of commercial buildings. DEEP, compiled from the results of about ten million EnergyPlus simulations, enables an easy screening of ECMs (energy conservation measures) and retro ﬁ t analysis. The simulations utilize prototype models representative of small and mid-size of ﬁ ces and retails in California climates. In the formulation of DEEP, large scale EnergyPlus simulations were conducted on high performance computing clusters to evaluate hundreds of individual and packaged ECMs covering envelope, lighting, heating, ventilation, air-conditioning, plug-loads, and service hot water. The architecture and simulation environment to create DEEP is ﬂ exible and can expand to cover additional building types, additional climates, and new ECMs. In this study DEEP is integrated into a web-based retro ﬁ t toolkit, the Commercial Building Energy Saver, which provides a platform for energy retro ﬁ t decision making by querying DEEP and unearthing recommended ECMs, their estimated energy savings and ﬁ nancial payback.
the glial reservoir: cells to

The development and maturation of the oligodendrocyte requires a series of highly orchestrated events that coordinate the proliferation and differentiation of the oligodendrocyte precursor cell (OPC) as well as the spatiotemporal regulation of myelination. In recent years, widespread interest has been devoted to the therapeutic potential of adult OPCs scattered throughout the central nervous system (CNS). In this review, we highlight molecular mechanisms controlling OPC differentiation during development and the implication of these mechanisms on adult OPCs for remyelination. Cell-autonomous regulators of differentiation and the heterogeneous microenvironment of the developing and the adult CNS may provide coordinated inhibitory cues that ultimately maintain a reservoir of uncommitted glia.
Wind tunnel testing of a swept tip shape and comparison with multi-ﬁdelity aerodynamic simulations

One promising design solution for increasing the efﬁciency of modern horizontal axis wind turbines is the installation of curved tip extensions. However, introducing such complex geometries may move traditional aerodynamic models based on Blade Element Momentum (BEM) theory out of their range of applicability. This motivated the present work, where a swept tip shape is investigated by means of both experimental and numerical tests. The latter group accounted for a wide 5 variety of aerodynamic models, allowing to highlight the capabilities and limitations of each of them in a relative manner. The considered swept tip shape is the result of a design optimization, focusing on locally maximizing power performance within load constraints. For the experimental tests, the tip model is instrumented with spanwise bands of pressure sensors and is tested in the Poul la Cour wind tunnel at the Technical University of Denmark (DTU). The methods used for the numerical tests consisted of a blade element model, a near-wake model, lifting-line free-wake models, and a fully resolved Navier- 10 Stokes solver. The comparison of the numerical and the experimental tests results is performed for a given range of angles of attack and wind speeds, which is representative of the expected conditions in operation. Results show that the blade element model cannot predict the measured normal force coefﬁcients, but the other methods are generally in good agreement with the measurements in attached ﬂow. Flow visualization and pressure distribution compare well with Computational Fluid Dynamics (CFD) simulations. The agreement in the clean case is better than in the tripped case, indicating an aggressive tripping of the 15 ﬂow in the measurements. Some uncertainties regarding the effect of the boundary layer at the inboard tunnel wall and the post stall behavior remain. The results in the ﬁgure show that there is a good agreement between LLTunnel and MIRAS results for the single wall version of the LLTunnel. The relatively small differences between the results can be explained by modeling differences for the 190 two codes. MIRAS includes the free wake effects, which are not included in LLTunnel. On the other hand LLTunnel extends the wake further downstream of the airfoil than MIRAS. The good agreement between the results show that the LLTunnel code is working as intended. The LLTunnel results in the ﬁgure also highlights the difference between the wing on a single wall difference the the solver predicted stall 20
Video Surveillance Over Wireless Sensor and Actuator Networks Video Surveillance Over Wireless Sensor and Actuator Networks Using Active Cameras Using Active Cameras

— Although there has been much work focused on the camera control issue on keeping tracking a target of interest, few has been done on jointly considering the video coding, video transmission, and camera control for effective and efﬁcient video surveillance over wireless sensor and actuator networks (WSAN). In this work, we propose a framework for real-time video surveillance with pan-tilt cameras where the video coding and transmission as well as the automated camera control are jointly op- timized by taking into account the surveillance video quality requirement andtheresourceconstraintofWSANs.Themaincontributionsofthisworkare:i)anautomatedcameracontrolmethodisdevelopedformovingtargettrackingbasedonthereceivedsurveillancevideoclipinconsiderationoftheimpactofvideotransmissiondelayoncameracontroldecisionmaking;ii)acontent-awarevideocodingandtransmissionschemeisinvestigatedto save network node resource and maximize the received video quality under the delay constraint of moving target monitoring. Both theoretical and experimental results demonstrate the superior performance of the proposed optimization framework over existing systems.
Undergraduate Dissertation Trabajo Fin de Grado Where is RP going?: A Study of the British Royal Family’s Speech

This dissertation aims at tracing the evolution that Received Pronunciation has experienced from its origins to nowadays. This evolution is followed from a historical, social and linguistic perspective, which reveals that RP may be diluting into other varieties of British English. In order to test this hypothesis, the Refined RP of the Royal Family has been taken as a symbol of steadiness that may have been affected by these changes. For this purpose, a corpus of video files has been selected with data from 1953 to nowadays, taking Queen Elizabeth II and the heirs to the throne, Prince Charles and Princes William and Harry, as representatives of the Royal Family‟s speech. Following the evolution of several phonetic and phonological features through the samples, it is concluded that the Queen‟s and Prince Charles‟s accents are moderately adapting to the new times while Princes William and Harry‟s RP is much more advanced and similar to the general, educated speech of their young contemporaries. These results would imply that RP is rapidly changing and probably, therefore, merging into more modern varieties such as Estuary English.
Implementation of a Group Encryption System in a Cloud-based Environment

— Nowadays, mobile devices offer almost the same level of functionality as standard personal computers. Cloud solution and faster Internet connections allow developers to build applications that do most of data processing in the cloud. On the other hand, cyber-crimes are growing problem and complex information system like cloud solutions are vulnerable to more threats. One of the most dangerous threats, i.e., data loss or leakage, requires countermeasures that will protect against dishonest cloud provider. Group encryption mechanisms are one of the key elements to ensure data privacy. This paper presents a new architecture for group encryption system that uses bilinear mappings. The architecture uses cloud solutions and supports mobile devices. Pros and cons of moving cryptographic operations to a cloud and resulting from the analysis of the demonstration system are discussed.
Classiﬁer Based on Inverted Indexes of Neighbors II. Theory and Appendix

A theory of a new method for the classification of data into classes is presented. The method is based on the sum of reciprocals of neighbors’ indexes. We show that neighbors’ indexes are in close relation to the approximate polynomial transform of the neighbors’ distances. The sum of the reciprocals of indexes for all neighbors forms truncated harmonic series due to a finite number of its elements. For the neighbors of one class there is a sum of the selected elements of this truncated series. It is proved that the ratio of these sums gives just the probability that the point to be classified – the query point – is of that class.
Long Range Planning Leveraging global sources of knowledge for business model innovation

This article explores the concept of leveraging global knowledge for business model innovation, whereby knowledge is transferred across space and firm boundaries for the reconfiguration of an incumbent firm's business model. Considering the implications of an ever-increasing fragmentation of global value chains and the associated dispersion of global knowledge sources, we propose that supply chain partners at foreign locations can provide valuable knowledge that incumbents can leverage to change their business model. Integrating insights from global supply chain, business model, and organizational learning literature, we theorize and empirically test how different organizational capabilities enable firms to acquire knowledge from foreign partners, integrate external with internal knowledge, transform knowledge through experimentation, and finally apply global knowledge in the form of business model innovation. We conclude with suggestions for future research. approach proposed by Rönkkö and Ylitalo (2011). The marker variable comprises of seven items obtained from constructs, such as market orientation, supplier orientation, and top management team involvement. We selected items with the lowest and most consistent correlation with the focal constructs. The marker items form a method construct as an exogenous variable that explains each of the focal constructs of the proposed research model. A comparison with the baseline model shows that parameter estimates remain stable and none of the significant path coefficients of the baseline model becomes insignificant. Based on both tests we infer that our findings are not impacted by endogeneity resulting from common method effects.
Impact of Chronic Kidney Disease on Carotid Atherosclerosis According to Blood Pressure Category The Suita Study Brief

of stenosis (>25%). The estimated glomerular filtration rate was calculated using the equations recommended by the Japanese Society of Nephrology. CKD was defined as estimated glomerular filtration rate <60 mL/min per 1.73 m 2 . Blood pressure categories were defined by the European Society of Hypertension and European Society of Cardiology 2007 criteria. Results —The multivariable-adjusted maximum carotid intima-media thickness and odds ratio for stenosis in subjects with estimated glomerular filtration rate <50 mL/min per 1.73 m 2 were greater than those in subjects with estimated glomerular filtration rate ≥ 90 mL/min per 1.73 m 2 . When subjects were stratified according to blood pressure categories, the multivariable-adjusted maximum carotid intima-media thickness was significantly greater in CKD subjects than in non-CKD subjects only in subjects with hypertension. Similarly, the impact of CKD on stenosis was evident only in subjects with hypertension (multivariable-adjusted odds ratios for stenosis [95% confidence interval] were 2.21 [1.53–3.19] in non-CKD/hypertension and 3.16 [2.05–4.88] in CKD/hypertension compared with non-CKD/optimal blood pressure). Conclusions —In a general population, the association of CKD with carotid atherosclerosis was modest, but CKD was independently associated with carotid atherosclerosis in subjects with hypertension. ( Stroke . 2013;44:3537-3539.) atherosclerosis defined as follows. Max-IMT was defined the maximum IMT in the entire area. Stenosis was defined as the presence of a stenotic area ≥ 25% on a cross-sectional scan. The eGFR was calculated using equations recommended by the Japanese Society of Nephrology. The subjects were categorized into 4 groups (eGFR 60–89, and mL/min per 1.73 m ) in our 2 CKD was defined as an eGFR <60 mL/min per 1.73 m 2 BP (optimal, normal, high-normal BP, and hypertension) were based on the Society of Hypertension and Society of 2007 of eGFR with carotid atherosclerosis and association of CKD with atherosclerosis BP examined covariance logistic regression sis, after cardiovascular covariates Methods BP category on carotid atherosclerosis, we analyzed the association between BP category and the carotid atherosclerosis index in subjects with and without CKD, using ANCOVA and logistic regression analysis, adjusting covariates (age, smoking and drinking status, blood glucose category, total and HDL cholesterol and body mass index). A P value <0.05 was considered significant for all comparisons. All analyses were performed with SAS statistical software (version 8.2; SAS Institute, Cary, NC, USA).
This is a repository copy of Study of two dose regimens of ticagrelor compared with clopidogrel in patients undergoing percutaneous coronary intervention for stable coronary artery disease

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