Miracle-dz/UniFAR-FTUs huggingface dataset:
Grand challenges in pediatric stroke

COPYRIGHT © 2023 Ullman and Licht. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Grand challenges in pediatric stroke
The prevalence of suicide attempt and suicidal ideation and its relationship with aggression and bullying in Chilean adolescents

Background Suicide constitutes one of the main mental health problems worldwide, requiring detection, and prevention efforts, especially in the adolescent population. Objective The purpose of this study was to estimate the prevalence of suicide attempts and suicidal ideation and their relationship with aggressiveness and bullying in Chilean adolescents. Materials and methods The sample was composed of 728 adolescents schooled from Arica city: 56.6% were males and 43.4% were females. The students attended from de 1st to the 4th year of secondary. The average age of the sample was 15,6 years. The following instruments were used: Okasha’s Suicidality Scale, Buss and Perry’s Aggressiveness Survey, and the Social Acceptance (School Bullying) sub-test of the Kidscreen-52 Survey. A cross-sectional, descriptive, and correlational design was applied. The sampling was non-probabilistic for convenience. Results 18.4% of the students reported that they had attempted suicide and 65.6% reported that they had suicidal ideation. The prevalence of suicide attempts was higher than in male adolescents (29,1% vs. 10,2%), and the same prevalence was for suicidal ideation (76,6% vs. 57,3%). Suicide attempts and suicidal ideation were positively and significantly correlated with aggressiveness (r = 0.32, r = 0.48) and bullying (r = 0.37, r = 0.50). Conclusion The prevalence of suicide attempts and suicidal ideation is both higher in girls than boys. In this sense, girls constitute a risk group. In addition, this study provides evidence that supports the relationship between suicide attempts and suicidal ideation. The results highlight the role that educational institutions should have in terms of prevention and effective approaches.
Connecting dots in disorders of gut-brain interaction: the interplay of stress and sex hormones in shaping visceral pain

Visceral pain and stress are tightly intertwined bodily and emotional phenomena, which enable a flexible adaptation to environmental challenges by activating a response repertoire to restore homeostasis along the gut-brain axis. However, visceral pain and stress can persist widely independent of the initial cause, acquiring independent disease values and posing major health burdens as predominant features in disorders of gut-brain interaction (DGBI). Epidemiological data consistently documents an increased prevalence for women to suffer from chronic visceral pain, possibly shaped by sex hormones and modulated by stress and its biological and psychosocial correlates. Yet, mechanisms underlying the complex interactions between altered visceroception, stress and sex remain widely elusive, especially in clinical populations with DGBI. We herein selectively review mechanisms of interactions between stress and sex in the complex pathophysiology of DGBI. A particular emphasis is laid on visceral pain, in which stress constitutes a major risk factor as well as mediator, and sex-related differences are particularly pronounced. Building on the neurobiology of stress and mechanisms of gut-brain interactions, we highlight putative target mechanisms via which visceral pain and stress may converge with sex effects into a triad. Accommodating a global demographic shift, we propose a lifespan perspective in future research, which may enable a more fine-tuned evaluation of this complex interplay exerting distinct challenges during vulnerable developmental phases. This viewpoint may advance our understanding of pathophysiological processes and can ultimately inspire novel tailored prevention strategies and therapeutic approaches in the treatment of chronic visceral pain and DGBI across the lifespan.
Trauma-related disorders and the bodily self: current perspectives and future directions

Trauma-related disorders are debilitating psychiatric conditions that influence people who have directly or indirectly witnessed adversities. Dramatic brain/body transformations and altered person's relationship with self, others, and the world occur when experiencing multiple types of traumas. In turn, these unfortunate modifications may contribute to predisposition to trauma-related vulnerability conditions, such as externalizing (aggression, delinquency, and conduct disorders) problems. This mini-review analyzes the relations between traumatic experiences (encoded as implicit and embodied procedural memories) and bodily self, sense of safety for the own body, and relationship with others, also in the presence of externalizing conducts. Furthermore, an emerging research area is also considered, highlighting principles and techniques of body-oriented and sensorimotor therapies designed to remodel bodily self-aspects in the presence of trauma, discussing their potential application with individuals showing externalizing problems.
Cardiac sarcoidosis: a comprehensive review of risk factors, pathogenesis, diagnosis, clinical manifestations, and treatment strategies

Cardiac Sarcoidosis (CS) is a deadly consequence of systemic sarcoidosis that inflames all three layers of the heart, especially the myocardium—clinical signs of CS range from asymptomatic disease to abrupt cardiac death. CS generally remains undiagnosed secondary to a lack of definitive diagnostic criteria, a high percentage of false negative results on endomyocardial biopsy, and ill-defining clinical manifestations of the disease. Consequently, there is a lack of evidence-based recommendations for CS, and the present diagnostic and therapeutic management depend on expert opinion. The aetiology, risk factors, clinical symptoms, diagnosis, and therapy of CS will be covered in this review. A particular emphasis will be placed on enhanced cardiovascular imaging and early identification of CS. We review the emerging evidence regarding the use of Electrocardiograms (ECGs), Magnetic Resonance Imaging (MRI), and Positron Emission Tomography (PET) imaging of the heart to identify and quantify the extent of myocardial inflammation, as well as to guide the use of immunotherapy and other treatment regimens, such as ablation therapy, device therapy, and heart transplantation, to improve patient outcomes.
A Computational Approach to the Ordinal Numbers

This paper expands Kleene’s notations for recursive ordinals to larger countable ordinals by defining notations for limit ordinals using total recursive functions on nonrecursively enumerable domains such as Kleene’s O. This leads to a hierarchy related to that developed with Turing Machine oracles or relative recursion. The recursive functions that define notations for limit ordinals form a typed hierarchy. They are encoded as Turing Machines that identify the type of parameters (labeled by ordinal notations) they accept as inputs and the type of input that can be constructed from them. It is practical to partially implement these recursive functional hierarchies and perform computer experiments as an aid to understanding and intuition. This approach is both based on and compliments an ordinal calculator research tool. 3.1 Objective mathematics Kleene’s O is part of what I call objective mathematics. O is a set of recursive ordinal notations defined using finite structures and recursive functions. ω 1 is the set of all recursive ordinals. The recursive ordinal notations in Kleene’s O are constructed using computer programs whose actions mirror the structure of the ordinal. Thus the ordinals represented in O have an objective interpretation in an always finite but possibly potentially infinite universe. Part of the motivation for generalizing Kleene’s O to notations for larger countable ordinals is to help to draw the boundaries of unambiguous mathematics that is physically definable and physically meaningful in an always finite but potentially infinite universe. Many others have attempted to draw related lines in various ways. Section 3.1. 2 discusses the objectivity of creative divergent processes with important properties that can only be defined by quantification over the reals. Even so these properties are objective and important in am always finite but potentially infinite universe. The Lowenheim-Skolem theorem proves that the uncountable is ambiguous in any finite or r. e. (recursively enumerable) formalization of mathematics. Any effective formal system, that has a model, must have a countable model. Thus, in contrast to much of mathematics[5], cardinality of the integers. This means that if the reals can be mapped onto a set (with a unique real for every object in the set) and the the integers cannot then that set can be mapped onto the reals with a unique object for every real.
A multicenter study on the quantification of liver iron concentration in thalassemia patients by means of the MRI T2* technique

Objective To investigate the feasibility and accuracy of quantifying liver iron concentration (LIC) in patients with thalassemia (TM) using 1.5T and 3T T2* MRI. Methods 1.5T MRI T2* values were measured in 391 TM patients from three medical centers: the T2* values of the test group were combined with the LIC (LICF) provided by FerriScan to construct the curve equation. In addition, the liver 3T MRI liver T2* data of 55 TM patients were measured as the 3T group: the curve equation of 3T T2* value and LICF was constructed. Results Based on the test group LICF (0.6–43 mg/g dw) and the corresponding 1.5T T2* value, the equation was LICF = 37.393T2 *∧(−1.22) (R2 = 0.971; P < 0.001). There was no significant difference between LICe − 1.5T and LICF in each validation group (Z = −1.269, −0.977, −1.197; P = 0.204, 0.328, 0.231). There was significant consistency (Kendall's W = 0.991, 0.985, 0.980; all P < 0.001) and high correlation (rs = 0.983, 0.971, 0.960; all P < 0.001) between the two methods. There was no significant difference between the clinical grading results of LICe − 1.5T and LICF in each validation group (χ2 = 3.0, 4.0, 2.0; P = 0.083, 0.135, 0.157), and there was significant consistency between the clinical grading results (Kappa's K = 0.943, 0.891, 0.953; P < 0.001). There was no statistical correlation between the LICF (≥14 mg/g dw) and the 3T T2* value of severe iron overload (P = 0.085). The LICF (2–14 mg/g dw) in mild and moderate iron overload was significantly correlated with the corresponding T2* value (rs = −0.940; P < 0.001). The curve equation constructed from LICF and corresponding 3T T2* values in this range is LICF = 18.463T2*∧(−1.142) (R2 = 0.889; P < 0.001). There was no significant difference between LICF and LICe − 3T in the mild to moderate range (Z = −0.523; P = 0.601), and there was a significant correlation (rs = 0.940; P < 0.001) and significant consistency (Kendall's W = 0.970; P = 0.008) between them. LICe − 3T had high diagnostic efficiency in the diagnosis of severe, moderate, and mild liver iron overload (specificity = 1.000, 0.909; sensitivity = 0.972, 1.000). Conclusion The liver iron concentration can be accurately quantified based on the 1.5T T2* value of the liver and the specific LIC-T2* curve equation. 3T T2* technology can accurately quantify mild-to-moderate LIC, but it is not recommended to use 3T T2* technology to quantify higher iron concentrations.
Major cardiovascular events and associated factors among routine hemodialysis patients with end-stage renal disease at tertiary care hospital in Somalia

Introduction Cardiovascular complications are the most significant cause of death in patients undergoing routine hemodialysi (HD) with end-stage renal disease (ESRD). The main objective of this study is to determine the significant cardiac events and risk factors in patients undergoing routine hemodialysis in Somalia. Methods We carried out a cross-sectional retrospective study in a single dialysis center in Somalia. Two hundred out of 224 were included. All of them had ESRD and were on hemodialysis during the study period between May and October 2021. The records of all patients were reviewed, and the following parameters were analyzed socio-demographic factors, risk factors for cardiovascular disease, and the presence of cardiovascular diseases. Results The mean age was 54 ± 17.5 years (range 18–88 years), and 106 (53%) patients were males. The prevalence of a cardiovascular disease among hemodialysis patients was 29.5%. Moreover, the distribution of cardiovascular diseases was different; heart failure was the most common, about 27.1%, followed by coronary artery disease (17%), pericarditis and pericardial-effusion (13.6%), dysrhythmia (10.2%), cerebrovascular-accident (8.5%), and peripheral vascular disease (3.4%). About 176 (88%) participants had at least one modifiable cardiovascular risk factor. The most common modifiable cardiovascular risk factor was hypertension (n = 45, 25.1%), followed by anemia (n = 28, 15.6%) and diabetes (n = 26, 14.5%). Younger (18–30) participants were six times less likely to have cardiovascular events among hemodialysis than older age 0.4 (0.11–1.12). Conclusion Low prevalence rate of cardiovascular complications was confirmed in ESRD patients receiving hemodialysis in the main HD center in Somalia. Diabetes, anemia, and hypertension were the highest significant risk factors for CVD in HD patients with ESRD in Somalia.
Self-perceived views on offender rehabilitation in detained adolescent boys: a qualitative analysis in the context of the good lives model

Introduction An upcoming offender rehabilitation model, the Good Lives Model (GLM), proposes that effective offender rehabilitation should adopt a dual focus: reducing recidivism risk as well as enhancing the offender’s well-being. To achieve this, the GLM suggests rehabilitation should include the prosocial fulfilment of a universal set of human needs termed “primary goods. ” A focus on primary goods attainment and well-being is hypothesized to improve treatment motivation and achieve more sustainable desistance from future offending. Although this model sounds promising, empirical evidence for these assumptions is limited, especially among youth. Methods Twenty Flemish and Dutch detained adolescent boys (14 to 17 years old at the time of their arrest) were interviewed during their detention using a semi-structured interview. They were asked about their well-being, needs and goals during rehabilitation, their treatment motivation, and their views on recidivism and rehabilitation. Results The results show that a match between the boys’ well-being needs, and the treatment goals set in collaboration with the institution could improve treatment motivation and rehabilitation efforts. The boys also mentioned other factors with a positive impact on their treatment motivation: increased levels of freedom and autonomy; having a future (prosocial) perspective; investing in a therapeutic alliance; and, working on individual factors (i.e., improving coping skills, school or work skills, and relationships with prosocial friends and family). Discussion These factors closely align with working on the GLM primary goods of “excellence in work and play,” “excellence in agency,” and “relatedness,” which can be helpful in enhancing well-being and treatment motivation in offender rehabilitation.
Reviewing the knowledge on the genus Patella in the Mediterranean Sea: testing the effect of protection on the mean abundance and size of Patella ferruginea

Increasing human pressure has strongly impacted the littoral environment, altering the habitats and population parameters of some species. The Mediterranean Sea is one of the regions that have been highly affected by these events. In response to these events, marine protected areas (MPAs) have emerged as one of the main conservation tools for marine habitats and species. In this regard, harvesting of limpets (Patella spp.) is a good example of the impact of human activity on the coast. Limpets are mollusks that are collected as food or fishing bait, and their exploitation causes an immediate decrease in the density and size structure of individuals. In the Mediterranean Sea, the genus Patella is represented by five species: Patella rustica, P. caerulea, P. ulyssiponensis, P. ferruginea, and P. depressa. To verify the effectiveness of the MPAs, a deep review of 75 studies on Patella spp. in the Mediterranean Sea was conducted to analyze the spatial and temporal distribution of studies. Data extracted from these articles were used to assess the effect of protection on the density and size of P. ferruginea. Regarding spatial distribution, the studies reviewed were performed at 67 sites in 13 countries, of which 23 were in MPAs and 44 in non-protected or control areas. The findings of this study show that P. ferruginea is the species most studied, because it is one of the most threatened marine invertebrates in the Mediterranean Sea. This explains the temporal distribution of the studies, which coincides with the establishment of the conservation status and the concern about the population status of P. ferruginea. Analysis of the effect of protection on the density and mean size of P. ferruginea individuals revealed no significant difference in mean density between the control sites and MPAs. However, mean size between individuals was significantly higher in MPAs than control sites. This pattern may be related to intra- and interspecific competition between individuals.
Recipient TIM4 signaling regulates ischemia reperfusion-induced ER stress and metabolic responses in liver transplantation: from mouse-to-human

T-cell immunoglobulin and mucin (Tim)4 is expressed on APCs, including macrophages, as one of the main amplifiers in the mechanism of liver ischemia-reperfusion injury (IRI) following orthotopic liver transplantation (OLT). Though donor Tim4 selectively expressed on Kupffer cells serves as a checkpoint regulator of innate immune-driven IRI cascades, its role on cells outside the OLT remains unclear. To dissect the role of donor vs. recipient-specific Tim4 signaling in IR-induced stress and hepatocellular function, we employed a murine OLT model utilizing Tim4-knockout (KO) mice as either donor or recipient (WT → WT, WT → Tim4-KO, Tim4-KO → WT). In the experimental arm, disruption of donor Tim4 attenuated IRI-OLT damage, while recipient Tim4-null mutation aggravated hepatic IRI concomitant with disturbed lipid metabolism, enhanced endoplasmic reticulum stress, and activated pro-apoptotic signaling in the grafts. In the in vitro study, murine hepatocytes co-cultured with Tim4-null adipose tissue showed enhanced C/EBP homologous protein (CHOP) expression pattern and susceptibility to hepatocellular death accompanied by activated caspase cascade in response to TNF-α stimulation. In the clinical arm, liver grafts from forty-one transplant patients with enhanced TIM4 expression showed higher body mass index, augmented hepatic endoplasmic reticulum stress, enhanced pro-apoptotic markers, upregulated innate/adaptive immune responses, exacerbated hepatocellular damage, and inferior graft survival. In conclusion, although TIM4 is considered a principal villain in peri-transplant early tissue injury, recipient TIM4 signaling may serve as a savior of IR-triggered metabolic stress in mouse and human OLT recipients.
Body composition and risk of liver cancer: a population-based prospective cohort study on gender difference

Background Obesity is a common and highly convincing risk factor for many cancers, including liver cancer. Sex disparities in the body composition and regulatory mechanisms involved in energy homeostasis may contribute to the difference in the incidence of cancer. However, evidence on the gender-specific association between body composition and liver cancer incidence is limited. We performed this study to investigate the linear and non-linear associations of body composition with liver cancer risk by gender. Materials and methods This prospective analysis included 4,75,659 participants free of cancer, based on the UK Biobank. We used Cox proportional hazard models to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) after adjusting for potential confounders. Restricted cubic spline was performed to investigate the potential non-linear associations. Results During a median follow-up, 275 cases (174 male patients and 101 female patients) of liver cancer were identified. Male patients in the highest body fat percentage group are more likely to develop liver cancer (HR = 1.89, 95% CI: 1.17–3.03) compared with those in the lowest group. The one-unit increase of whole-body fat mass, arm fat mass, and trunk fat mass was associated with 1.03-, 1.14-, and 1.05-fold increased risk of liver cancer in male subjects, respectively. U-shaped associations of body composition with liver cancer risk were observed in the female subjects. Both high and low levels of whole-body fat-free mass, particularly in the arm and trunk, were associated with an increased risk of liver cancer. Conclusion This study found a gender-specific association between body composition and liver cancer risk and provided evidence for individualized weight management for the prevention of liver cancer.
Efficient computation method for joint DOD–DOA estimation in bistatic MIMO radar

ABSTRACT In this article, an efficient computation method for joint direction of departure (DOD) and direction of arrival (DOA) estimation in bistatic multiple-input and multiple-output radar is presented. Firstly, an extended matrix can be obtained from received signal data, which includes two times sampling number of the data samples. Then, exploiting the unitary transformation, the extended matrix can be turned into a real-valued one, and the propagator method is applied to estimate the real valued signal subspace without any eigenvalue decomposition (EVD) of the covariance matrix. Finally, the subspace method can be used for joint DOD and DOA estimation. Compared with traditional subspace-based methods, the proposed method only involves real-valued processing and avoids EVD of covariance matrix. Thus, the proposed method has lower computational complexity. Furthermore, the proposed method can provide better angle estimation due to the double number of data samples. Simulations results are provided to verify the effectiveness of the proposed method.