Miracle-dz/UniFAR-FTUs huggingface dataset:
Push-Out Bond Strength of Calcium Silicate-Based Cements in the Presence or Absence of a Smear Layer

Objectives Variations between the material compositions and the presence of a smear layer on the dentin surface may influence the bond strength of the material, thus this study evaluated the push-out bond strength of different calcium silicate materials to root dentin in the presence or absence of smear layer. Materials and Methods The palatal canal of sixty maxillary first premolars were prepared and divided into three groups according to the materials to be used: ProRoot WMTA, Biodentine, and TotalFill FS. Each group was then divided into two subgroups; with and without a smear layer. Roots were sectioned into three slices and filled with the tested materials. Push-out bond strength of materials was measured by universal machine. Results Bond strength of Biodentine was significantly higher than the MTA and TotalFill FS in the presence or absence of smear layer. Overall, removing the smear layer reduced the bond strength of the three materials. The reduction was significant for MTA and TotalFill FS but not for Biodentine. Conclusions Biodentine demonstrated the highest bond strength to radicular dentin followed by MTA, and then TotalFill FS. Overall, removal of the smear layer from dentin surface reduced the bond strength of the calcium silicate root repair materials.
Passive patient or active agent? An under-explored perspective on the benefits of time in nature for learning and wellbeing

COPYRIGHT © 2022 Chawla. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Passive patient or active agent? An under-explored perspective on the benefits of time in nature for learning and wellbeing
Bacteria Load Determination of the Intestinal Microbiota and Identification of Spiroplasma and Wolbachia in Anopheles gambiae

The gut microbiota of mosquitoes is composed of a range of microorganisms. Among its microorganisms, some affect the vectorial capacity of mosquitoes. The aim of this study was to characterize some bacteria of the intestinal microbiota in Anopheles gambiae (An. gambiae) females, a major vector of malaria transmission in Benin. The symbiote bacteria of the microbiota of female laboratory An. gambiae and female wild An. gambiae were identified by the culture method. The count was done on media plate count agar (PCA), and subsequently, the bacterial load was calculated. Comparison of batches bacterial load was carried out with the variance analysis test (ANOVA). Finally, polymerase chain reaction (PCR) was performed to investigate the presence of a few bacterial genera influencing the vector capacity of An. gambiae. The study found that the microbiota of female An. gambiae is home to the bacteria belonging to the Staphylococcus, Enterobacteriaceae, and other unidentified bacterial gene regardless of its nature and condition. Similarly, there was no statistically significant difference between the bacterial load of the laboratory and wild mosquitoes depending on the parous and gorged states; on the other hand, there was a significant difference between the bacterial loads of the laboratory and wild mosquitoes according to the nulliparous and nongorged states. The search for a few bacterial genera influencing the vector capacity of female An. gambiae has been negative for Spiroplasma bacteria regardless of its nature and condition. PCR revealed the presence of Wolbachia bacteria for only gorged Kisumu sensitive An. gambiae. Wolbachia’s presence at An. gambiae suggests that this type of bacteria could be used to develop new effective and sustainable approaches in the vector control.
A 10 W Multi-Mode Capable Wireless Power Amplifier for Mobile Devices

There are currently 3 wireless power standards for the mobile device market: the Wireless Power Consortium (Qi) standard [1], the Power Matters Alliance (PMA) standard [2] and the Alliance for Wireless Power (A4WP) standard [3]. Recently PMA and A4WP merged to become known as AirFuel(TM). The proliferation of wireless power products for mobile applications is leading to consumer confusion and hindering adoption of this technology [4]. A simple eGaN© integrated circuit based, single amplifier topology capable of operating to all of the mobile device wireless power standards is presented. It uses a modified ZVS class D amplifier topology capable of operating at both high (6.78 MHz) and low frequencies (100 kHz through 315 kHz). In addition, a specially designed source coil that can be used for all the wireless power standards is presented. The amplifier and source coil together allow for true multi-mode capable wireless power transfer that will be experimentally verified to both the AirFuel class 2 [5] and Qi/PMA [1, 2] standards and are designed for mobile phone charging applications.
Development of a T Cell-Based COVID-19 Vaccine Using a Live Attenuated Influenza Vaccine Viral Vector

The COVID-19 pandemic emerged in 2020 and has caused an unprecedented burden to all countries in the world. SARS-CoV-2 continues to circulate and antigenically evolve, enabling multiple reinfections. To address the issue of the virus antigenic variability, T cell-based vaccines are being developed, which are directed to more conserved viral epitopes. We used live attenuated influenza vaccine (LAIV) virus vector to generate recombinant influenza viruses expressing various T-cell epitopes of SARS-CoV-2 from either neuraminidase (NA) or non-structural (NS1) genes, via the P2A self-cleavage site. Intranasal immunization of human leukocyte antigen-A*0201 (HLA-A2.1) transgenic mice with these recombinant viruses did not result in significant SARS-CoV-2-specific T-cell responses, due to the immunodominance of NP366 influenza T-cell epitope. However, side-by-side stimulation of peripheral blood mononuclear cells (PBMCs) of COVID-19 convalescents with recombinant viruses and LAIV vector demonstrated activation of memory T cells in samples stimulated with LAIV/SARS-CoV-2, but not LAIV alone. Hamsters immunized with a selected LAIV/SARS-CoV-2 prototype were protected against challenge with influenza virus and a high dose of SARS-CoV-2 of Wuhan and Delta lineages, which was confirmed by reduced weight loss, milder clinical symptoms and less pronounced histopathological signs of SARS-CoV-2 infection in the lungs, compared to LAIV- and mock-immunized animals. Overall, LAIV is a promising platform for the development of a bivalent vaccine against influenza and SARS-CoV-2.
Deciphering the Genetic Basis of Root and Biomass Traits in Rapeseed (Brassica napus L.) through the Integration of GWAS and RNA-Seq under Nitrogen Stress

An excellent root system is responsible for crops with high nitrogen-use efficiency (NUE). The current study evaluated the natural variations in 13 root- and biomass-related traits under a low nitrogen (LN) treatment in a rapeseed association panel. The studied traits exhibited significant phenotypic differences with heritabilities ranging from 0.53 to 0.66, and most of the traits showed significant correlations with each other. The genome-wide association study (GWAS) found 51 significant and 30 suggestive trait–SNP associations that integrated into 14 valid quantitative trait loci (QTL) clusters and explained 5.7–21.2% phenotypic variance. In addition, RNA sequencing was performed at two time points to examine the differential expression of genes (DEGs) between high and low NUE lines. In total, 245, 540, and 399 DEGs were identified as LN stress-specific, high nitrogen (HN) condition-specific, and HNLN common DEGs, respectively. An integrated analysis of GWAS, weighted gene co-expression network, and DEGs revealed 16 genes involved in rapeseed root development under LN stress. Previous studies have reported that the homologs of seven out of sixteen potential genes control root growth and NUE. These findings revealed the genetic basis underlying nitrogen stress and provided worthwhile SNPs/genes information for the genetic improvement of NUE in rapeseed.
Physical exercise increases perceived musical pleasure: Modulatory roles of arousal, affect, or dopamine?

Music’s ability to influence exercise performance is well known, but the converse, how exercise influences music listening, remains largely unknown. Exercise can elevate arousal, positive affect, and neurotransmitters including dopamine, which are involved in musical pleasure. Here we examine how exercise influences music enjoyment, and test for a modulatory role of arousal, affect, and dopamine. Before and after exercise (12 min of vigorous running) and a rest control session, participants (N = 20) listened to music clips and rated their enjoyment and subjective arousal; we also collected ratings of affect and eye-blink rates, an established predictor of dopamine activity. Ratings of musical enjoyment increased significantly after exercise, but not after the rest control condition. While changes in subjective arousal ratings did not differ between exercise and control conditions, change in subjective arousal correlated with change in music enjoyment. After exercise, the change in music enjoyment had a positive but non-significant correlation with change in eye-blink rates (r = .36). Positive affect increased more after exercise than after the control session, but the change in positive affect did not correlate with change in music enjoyment. In sum, exercise leads to increased musical enjoyment, and this effect was related to changes in arousal.
Improvement of Depressed Mood with Green Tea Intake

Being in a prolonged depressed state increases the risk of developing depression. To investigate whether green tea intake is effective in improving depression-like moods, we used an experimental animal model of depression with lipopolysaccharide (LPS) and clarified the effects of green tea on the biological stress response and inflammation in the brain. Regarding the stress reduction effect of green tea, we found that the sum of caffeine (C) and epigallocatechin gallate (E) relative to the sum of theanine (T) and arginine (A), the major components of green tea, or the CE/TA ratio, is important. The results showed that depression-like behavior, adrenal hypertrophy as a typical stress response, and brain inflammation were suppressed in mice fed green tea components with CE/TA ratios of 2 to 8. In addition, the expression of Npas4, which is reduced in anxiety and depression, was maintained at the same level as controls in mice that consumed green tea with a CE/TA ratio of 4. In clinical human trials, the consumption of green tea with CE/TA ratios of 3.9 and 4.7 reduced susceptibility to subjective depression. These results suggest that the daily consumption of green tea with a CE/TA ratio of 4–5 is beneficial to improving depressed mood.
Non-invasive brain stimulation associated mirror therapy for upper-limb rehabilitation after stroke: Systematic review and meta-analysis of randomized clinical trials

Background Non-invasive brain stimulation (NIBS) techniques and mirror therapy (MT) are promising rehabilitation measures for stroke. While the combination of MT and NIBS has been employed for post-stroke upper limb motor functional rehabilitation, its effectiveness has not been examined. Objective This study aimed to evaluate the effectiveness of combined MT and NIBS in the recovery of upper limb motor function in stroke patients. Methods The search was carried out in PubMed, EMBASE, Cochrane Library, Web of Science, Science Direct, CNKI, WANFANG and VIP until December 2021. Randomized clinical trials (RCTs) comparing MT or NIBS alone with the combination of NIBS and MT in improving upper extremity motor recovery after stroke were selected. A meta-analysis was performed to calculate the mean differences (MD) or the standard mean differences (SMD) and 95% confidence intervals (CI) with random-effect models. Subgroup analyses were also conducted according to the types of control group, the types of NIBS, stimulation timing and phase poststroke. Results A total of 12 articles, including 17 studies with 628 patients, were reviewed in the meta-analysis. In comparison with MT or NIBS alone, the combined group significantly improved body structure and function (MD = 5.97; 95% CI: 5.01–6.93; P < 0.05), activity levels (SMD = 0.82; 95% CI 0.61–1.02; P < 0.05). For cortical excitability, the motor evoked potential cortical latency (SMD = −1.05; 95% CI:−1.57–−0.52; P < 0.05) and the central motor conduction time (SMD=-1.31 95% CI:−2.02-−0.61; P < 0.05) of the combined group were significantly shortened. A non-significant homogeneous summary effect size was found for MEP amplitude (SMD = 0.47; 95%CI = −0.29 to 1.23; P = 0.23). Subgroup analysis showed that there is an interaction between the stimulation sequence and the combined treatment effect. Conclusion In this meta-analysis of randomized clinical trials, in comparison to the control groups, MT combined with NIBS promoted the recovery of upper extremity motor function after stroke, which was reflected in the analysis of body structure and function, activity levels, and cortical excitability. Systematic review registration https://www.crd. york.ac. uk/prospero/, identifier CRD42022304455.
Intelligent Process Automation: An Application in Manufacturing Industry

Background: The intelligent processes automation has been cataloged as one of the most potential and strategic technology solutions to develop a corporate digital transformation. Method: This paper introduces essential concepts to create Intelligent Process Automation (IPA) in industries and proposes a framework to implement IPA technologies successfully. The approach involves: firstly, assembling a good implementation setup and deeply researching the process using process mining techniques. Secondly, choosing and locating the best AI technology inside the IPA. Finally, defining an appropriate architecture of the IPA. Results: The paper illustrates an IPA use case in the manufacturing industry, where it is possible to automate the process of sending production orders to a manufacturing plant and optimize waste and plant capacity significantly. Conclusions: The research depicts the potential of intelligent process automation and its quantifiable benefits in the manufacturing process, and the contribution can be applied to different enterprises with a global context.
A data-driven machine learning approach for brain-computer interfaces targeting lower limb neuroprosthetics

Prosthetic devices that replace a lost limb have become increasingly performant in recent years. Recent advances in both software and hardware allow for the decoding of electroencephalogram (EEG) signals to improve the control of active prostheses with brain-computer interfaces (BCI). Most BCI research is focused on the upper body. Although BCI research for the lower extremities has increased in recent years, there are still gaps in our knowledge of the neural patterns associated with lower limb movement. Therefore, the main objective of this study is to show the feasibility of decoding lower limb movements from EEG data recordings. The second aim is to investigate whether well-known neuroplastic adaptations in individuals with an amputation have an influence on decoding performance. To address this, we collected data from multiple individuals with lower limb amputation and a matched able-bodied control group. Using these data, we trained and evaluated common BCI methods that have already been proven effective for upper limb BCI. With an average test decoding accuracy of 84% for both groups, our results show that it is possible to discriminate different lower extremity movements using EEG data with good accuracy. There are no significant differences (p = 0.99) in the decoding performance of these movements between healthy subjects and subjects with lower extremity amputation. These results show the feasibility of using BCI for lower limb prosthesis control and indicate that decoding performance is not influenced by neuroplasticity-induced differences between the two groups.
Tigecycline for Severe Rickettsioses: Gained Experience Needing a Slight Grain of Salt

We read with interest the article by Mastroianni and colleagues titled “Does Tigecycline Have a Place in Therapy for Rickettsial Infection of the Central Nervous System [1]. ” In this report, the authors describe their experience using tigecycline to treat those with neurologic manifestations of spotted fever group (SFG) rickettsiosis in Italy. In their series of 5 patients, they report a favorable response to the use of high dose tigecycline (200 mg loading dose followed by 100 mg administered twice daily). Tigecycline, a relatively unproven antibiotic for clinical rickettsioses, has in vitro activity against several tested rickettsiae [2, 3] and appears effective in an animal model for lethal Rocky Mountain spotted fever (RMSF) [3]. Although doxycycline is the agent of choice, manifestations such as nausea/vomiting or concern for impaired absorption associated with critical illness, may preclude its oral use. Unfortunately, as highlighted by this article, the parenteral formulation is not always available in some regions [1, 3]. Sharing clinical therapeutic experience through publication of observational studies is of importance when controlled trials are not feasible, so the case series by Mastroianni et al. [1] may be very helpful to clinicians faced with severe manifestations of SFG rickettsioses without the availability of intravenous doxycycline.
Comparison of MRI, CA-125 and HE-4 in determining the depth of myometrial invasion in cases with endometrial cancer

To cite this article: Samican Özmen, Sefa Kurt, Orkun Ilgen, Funda Barlik Obuz, Ali Riza Sisman, Meral Koyuncuoglu. Comparison of MRI, CA-125 and HE-4 in determining the depth of myometrial invasion in cases with endometrial cancer. J Clin Invest Surg. 2021; 6(1): 22-29. doi: 10.25083/2559.5555/6.1. 5 Comparison of MRI, CA-125 and HE-4 in determining the depth of myometrial invasion in cases with endometrial cancer Samican Özmen , Sefa Kurt, Orkun Ilgen, Funda Barlik Obuz, Ali Riza Sisman, Meral Koyuncuoglu
Development of Antibiotic Resistance, Suggestion For The Safety of Our Future Generation

1. Professor, Department of Urology, Khwaja Yunus Ali Medical College Hospital, Enayetpur, Sirajganj, Bangladesh. 2. Associate Professor, Department of Urology, Khwaja Yunus Ali Medical College Hospital, Enayetpur, Sirajganj, Bangladesh. 3. Professor (CC) Department of Skin & VD, Khwaja Yunus Ali Medical College Hospital, Enayetpur, Sirajganj, Bangladesh. 4. Associate Professor Department of Urology, Dhaka Medical College Hospital, Dhaka, Bangladesh. 5. Assistant Register, Department of Urology, Khwaja Yunus Ali Medical College Hospital, Enayetpur, Sirajganj, Bangladesh. 6. Indoor Medical Officer (IMO), Department of Urology, Khwaja Yunus Ali Medical College Hospital, Enayetpur, Sirajganj, Bangladesh. 7. Indoor Medical Officer (IMO), Department of Urology, Khwaja Yunus Ali Medical College Hospital, Enayetpur, Sirajganj, Bangladesh. 8. Indoor Medical Officer (IMO), Department of Urology, Khwaja Yunus Ali Medical College Hospital, Enayetpur, Sirajganj, Bangladesh. 9. Indoor Medical Officer (IMO), Department of Urology, Khwaja Yunus Ali Medical College Hospital, Enayetpur, Sirajganj, Bangladesh.
Topology study for an inductive power transmitter in cordless kitchen system

In a cordless kitchen system, the appliances do not make use of a power cord. The system consists of a power channel and a communication channel. There are various resonant topologies which can be implemented in the power channel[9]. The chosen topology should meet the functional as well as non-functional equirements of the system. Presently, a series resonant topology is used in the system. The topology is easy to understand, to implement and could meet the functional requirements like the amount of power and high efficiency of the system easily. But, it is difficult to meet the non-functional requirements like overvoltage protection, EMI and simple control of the system. This master’s thesis is mainly focused on design and realization an inductive power transmitter which addresses the following research questions: • EMI: The present inductive power transmitter is based on a series resonant inverter which has a disadvantage of high dV/dt’s across the inverter bridge and the transmitter coil. Furthermore, ZVS of the power switches can be lost at low duty cycles or low loads. Both mechanisms causes high dV/dt’s in the system, which results in increase in common mode noise problems. • Overvoltage: The present series resonant topology with the calculated circuit components and given load conditions (coupling factor (k) and load resistance (RL)), is observed to be operating in the capacitive mode of operation, when the load is disconnected/removed. Therefore, disconnection of the load causes overvoltage on the transmitter as well as the receiver coil. The overvoltage, in the absence of ’expensive’ protective means, can damage the system components and the system may fail to operate. • Simple control: The present system is a 4th order system. Due to weak coupling between the transmitter and the receiver coils, there exists multiple operating points where the voltage gain is the same. Therefore, it is difficult to find an optimal operating point for the control loop. Also, as mentioned in previous point, the load disconnection results in capacitive mode of operation of the system. To protect the system the control loop should take care that the system operates in the desired inductive mode of operation, as fast as possible and without causing significant losses. The report proceeds with an introduction about the cordless kitchen project. It is followed by the description and the analysis of the present system. Next, the detailed analysis of other possible topologies and selection of the alternative topology is described. It is followed by the description about the new proposed model. The report concludes with the conclusion and a paper publication. The paper is published during the Wireless Power Congress arranged by WEKA FACHMEDIEN GmbH in July-2017.
Numerical analysis of electromagnetic field in devices with the high-speed unit

Purpose The purposes of this paper are to numerically analyse the distribution of the electromagnetic field in the electromagnetic device wherein a high-speed unit exists and to develop a strong tool to analyse the evolution of an electromagnetic field tangled with moving parts. Design/methodology/approach The precise integration time domain (PITD) method and parameter weighted averaging approximation scheme. Findings It is shown that that the electromagnetic field in the device is significantly affected by the velocity of the moving unit and the parameters of the base material. The computation resources of the proposed method are saved and the efficiency is enhanced. Originality/value The parameter approximation (PA)-PITD method can be an effective and efficient time domain method to analyse the evolution of the electromagnetic field in electromagnetic devices with moving parts and similar problems.