Miracle-dz/UniFAR-FTUs huggingface dataset:
THE MEDIATION EFFECT OF SATISFACTION ON THE RELATIONSHIP BETWEEN TRAVEL MOTIVATIONS AND BEHAVIORAL INTENTIONS

Studies show that there is no consensus in the literature on the relationships between motivations, satisfaction, and behavioral intentions. Inconsistent results of prior studies are the main motive of the current research. The current research, it was examined the mediating effect of tourist satisfaction on the relationship between travel motivations and behavioral intentions. The population of the research is domestic tourists, and the research was conducted in Mardin which is found in Southeastern Anatolia, Türkiye. Research data was collected through a questionnaire and convenience sampling method (n= 390). The bootstrapping method was used to test the mediation effect. According to the results of the analysis, the hypothesis developed regarding the partial mediating role of tourist satisfaction in the impact of travel motivations on behavioral intentions was partially supported. Also, the mediating role has been found to be significant. The research findings were discussed within the scope of the literature, and some suggestions were made.
A Bias in the Midtropospheric Channel Warm Target Factor on theNOAA-9Microwave Sounding Unit

AbstractThe University of Alabama at Huntsville (UAH), Remote Sensing Systems (RSS), and the National Oceanic and Atmospheric Administration (NOAA) have constructed long-term temperature records for deep atmospheric layers using satellite Microwave Sounding Unit (MSU) and Advanced Microwave Sounding Unit (AMSU) observations. However, these groups disagree on the magnitude of global temperature trends since 1979, including the trend for the midtropospheric layer (TMT). This study evaluates the selection of the MSU TMT warm target factor for the NOAA-9 satellite using five homogenized radiosonde products as references. The analysis reveals that the UAH TMT product has a positive bias of 0.051 ± 0.031 in the warm target factor that artificially reduces the global TMT trend by 0.042 K decade−1 for 1979–2009. Accounting for this bias increases the global UAH TMT trend from 0.038 to 0.080 K decade−1, effectively eliminating the trend difference between UAH and RSS and decreasing the trend difference between UAH.
Clinical trials of cellular therapies for the treatment of colorectal cancer: a narrative review

– Colorectal cancer (CRC) treatment us-ing common chemotherapy approaches has drawbacks such as side effects, costs, and resistance of cancer cells which affects patients’ prolonged survival, and quality of life. The immune cells have pivotal roles in regulating tumor progression in the tumor microenvironment (TME). The most important CRC cellular immuno-therapies include the use of tumor-derived cells such as tumor-infiltrating lymphocytes (TILs) and lymph node lymphocytes (LNLs), peripheral blood mononuclear cells (PBMCs), derived cells, including T cells, natural killer (NK) cells, cytokine-induced killer (CIK) cells, and chimeric antigen receptor (CAR) cells. Although adoptive cell therapy has some advantages, some disadvantages have been reported. TILs cells are strictly directed against tumor-specific antigens; however, they are inefficient due to immune editing. CIK cells have a major histocompatibility complex (MHC)-independent cytotoxic effect and need concurrent high-dose interleukin (IL)-2 administration. In
Evaluation of Oral Food Provocation Test Results in Children Diagnosed with Food Allergy

Aims : Our study was conducted to evaluate the results of the oral food provocation tests in children with a diagnosis of food allergy and to examine the development of reactions in patients during the oral food provocation test. Material and Method : This was a descriptive type of study. Children diagnosed with food allergy between the years 2020-2022, and who had an oral food provocation test were included in the study. The patient files were scanned retrospectively. Age, gender, allergy tests, total IgE, eosinophil values and reactions during treatment were evaluated. Results : Oral food provocation test was applied to 40.5% (n=85) of the patients for diagnostic purposes and 59.5% (n=125) to determine the food tolerance. Of the patients who received oral provocation, 48.1% (n=101) received yoghurt, 39.0% (n=82) eggs, 5.7% (n=12) baked egg cake, 4.8% (n=10), baked yoghurt cake. Reaction was observed in 8.6% (n=18) of the patients who received oral food provocation test. Reactions were mostly urticaria. There was no statistically significant relationship between the development of the reaction and gender, the purpose of the provocation test, the age of onset of the first complaints and the age at which the provocation test was applied (p>0.05). The median specific IgE (milk) value was higher in patients who developed a reaction (p=0.034). Conclusions : Reaction developed less than one in ten of the patients. Although the reactions are often mild such as urticaria, it is important to predict the development of the reaction in terms of the management of food allergies and the feasibility of the provocation test.
DeepSearch: A deep learning based document retrieval system

Deep learning has enabled machines to be used for many tasks, including computer vision, image recognition, natural language processing, self-driving cars, and predicting the contingencies of certain business transactions. Eﬀective application of deep learning techniques can help develop intelligent applications. Many web-based tools get their information from generic search engines such as Google but also specialized search engines such as PubMed (for retrieving information on biomedical publications). In this study, we evaluate the performance of diﬀer-ent deep learning architectures for the task of document retrieval. Our goal was to identify the optimal architecture for the document retrieval task. We therefore compare the deep architecture of feed-forward neural networks with recurrent neural networks, in particular the long short-term memory neural networks. We observe that the local context is not suﬃcient as it does not provide reliable predictions, which are, however, provided by long distance dependencies where long short-term memory neural networks are used. We ﬁrst describe the algorithms used for our evaluation and then compare their performance. Our dataset contained two publicly available document sets from the 20-Newsgroup and BBC, respectively.
Comparison of Morpho-skeletal Characteristics (using Standardised Criteria Sets) of the Great Tit Parus major (Linnaeus 1758) in Three Iranian Populations (Mashhad, Noor and Hamedan)

In order to study morphometrical and skeletal differences between three populations of the Iranian subspecies of the Great Tits Parus major, 40 specimens were collected during autumn 2001 to spring 2002. The specimens were obtained from three localities: Vakilabad forest park (Mashhad), Noor forest park (Noor) and Abbasabad gardens on the southern slopes of Alvand Mountain (Hamedan), representing P.m. intermedius, P.m. karelini and P.m. blanfordi, respectively. We utilised a large set (29) of morpho-skeletal characteristics for comparison in univariate and multivariate analyses using SPSS and Past programs. The Bonferonni univariate test revealed that 21 characteristics were significantly different among the three populations (p<0.05). The Tukey multivariate test showed that in a pairwise comparison of the measured factors among three paired populations, only nares to tip, humerus and mid-toe length were different in all the three pairwise populations, while wing breadth, tail length, tail index, carpo-metacarpus, tarso-metatarsus bone, brain-case height, brain-case breadth, lacrymal breadth and mandible length differed in only one of the three paired populations, and body length, shield width, wingspan, wing length, proportion of white wedge of the outer pair tail feathers to tail length, femur, tibiotarsus, profile length and height of the ramus mandible differed in two paired populations (p<0.05). There was no significant difference between any of the three pairwise populations for the remaining factors, i.e. bill length, bill depth, tarso-metatarsus length, ulna, radius, coracoid, interorbital constriction and bill length by side (p>0.05). While PCA analysis showed that the populations of Mashhad and Noor are of different ecotypes, cluster analysis (which considered all morphometric measurements) suggested the Hamedan birds as the most differentiated population of the three. Mitochondrial sequences by other authors showed that the three geographically close populations are distinct from each other.
Multiphysics Simulation of Low-Amplitude Acoustic Wave Multiphysics Simulation of Low-Amplitude Acoustic Wave Detection by Piezoelectric Wafer Active Sensors Validated by In-Detection by Piezoelectric Wafer Active Sensors Validated by In-Situ AE-Fatigue Experiment Situ AE-Fatigue Experiment

: Piezoelectric wafer active sensors (PWAS) are commonly used for detecting Lamb waves for structural health monitoring application. However, in most applications of active sensing, the signals are of high-amplitude and easy to detect. In this article, we have shown a new avenue of using the PWAS transducer for detecting the low-amplitude fatigue-crack related acoustic emission (AE) signals. Multiphysics ﬁnite element (FE) simulations were performed with two PWAS transducers bonded to the structure. Various conﬁgurations of the sensors were studied by using the simulations. One PWAS was placed near to the fatigue-crack and the other one was placed at a certain distance from the crack. The simulated AE event was generated at the crack tip. The simulation results showed that both PWAS transducers were capable of sensing the AE signals. To validate the multiphysics simulation results, an in-situ AE-fatigue experiment was performed. Two PWAS transducers were bonded to the thin aerospace test coupon. The fatigue crack was generated in the test coupon which had produced low-amplitude acoustic waves. The low-amplitude fatigue-crack related AE signals were successfully captured by the PWAS transducers. The distance effect on the captured AE signals was also studied. It has been shown that some high-frequency contents of the AE signal have developed as they travel away from the crack.
Modeling linked open data for decision support in Thailand tourism

Linked Data has become a standard for achieving semantic web. This paper presents an approach to Linked Open Data (LOD) modeling in development of Web of Data based on LOD standards and methodologies to manage the complexity of the domain of interest. An example from the domain Tourism exemplifies the approach applicable for LOD development and focuses on the design methods and techniques: designing relational data model from various standards and stakeholders in tourism industry; transformations between relational and RDF/OWL data models; and tourism ontology development mainly using Protégé. The approach uses the process of mapping relational data to Linked Data and key processes of LOD modeling and prototyping of Web of Data. The approach proposed is implemented as data visualization of key tourism indicators to illustrate the key processes of LOD modeling, and prototyping of Web of Data for the industry.
Integrated Life‐Cycle Design of Materials and Structures

Integrated life cycle design is an important tool for sustainable civil engineering. It aims to concretise the multiple requirements of functionality, economy, resistance, aesthetics and ecology into technical specifications and further into designs of materials and structures. With this objective in mind we have to extend the scope of structural design and develop the design process. The extended design must also include multiple calculation methods in which calculations of life cycle monetary economy are added to those of life-cycle natural economy in other words ecology. Safety and mechanical serviceability are guaranteed by traditional mechanical design with statistical and dynamics methods. Controlled technical serviceability throughout the target service life is guaranteed by durability design. Health is protected by methods of building physics, including hygrothermal physical and chemical methods. Design for recycling is a special area with its own considerations and methods. The selection of final solutions between alternative structural ideas, materials and products can be done by applying the methods of multiple requirements decision-making. Modular product and performance systematics can be applied at several of the design phases. The methodology of integrated life cycle design can be used at the design of individual buildings or other structural facilities, as well as in the develonment of new I materials and structures or structural systems. Many research results exist which allow the introduction of new design methods into praxis. However, new basic knowledge is needed especially in regard to hygrothermal behaviour, durability and service life of materials and structures in varying environments. This knowledge will then have to be put into practice through standards and practical guides. The creation of new types of materials and structures in which the properties can be tailored to each specific need is of vital importance. Before integrated life cycle design can be introduced into practice, many new guides and standards will be needed. Some such guidelines already exist as international and national standards, but do not yet suffice. Extensive education will also be needed to give practising engineers the required skills in the expanded design process and its methods.
Acute Epstein–Barr virus positive cytotoxic T/Nature Killer cell lymphoid hyperplasia (AEBV+CT/NK-LH) mimicking natural killer/T cell lymphoma

To describe the clinicopathological features of seven patients with acute Epstein–Barr virus (EBV)-positive cytotoxic T cell/ natural killer lymphoid hyperplasia (AEBV + CT/NK-LH) in the lymphnode, in which initial �ndings led to a preliminary misdiagnosis of extranodal NK/T cell lymphoma(NKTL). Seven cases in children and young people from China with AEBV + CT/NK-LH were retrospectively analyzed. The patients were healthy prior to illness. Sudden onset occurred in all patients, with high fever as the �rst symptom followed by lymphadenopathy and hepatosplenomegaly. The disease courses before diagnosis were less than 1.5 months. The majority of lymphocytes in the lesions expressed CD3 and Granzyme B or TIA-1, but not CD5 in all cases. CD56 was expressed in numerous cells in 5 of 7 cases. EBER was detected in medium to large-sized cells (50–100 cells per high-power �eld) in all cases. TCR gene rearrangement was observed in six cases, among which monoclonal rearrangement was found in four cases. All patients received conservative treatment, but not chemotherapy. Four patients underwent anti-HLH therapy, and the others received anti-inammatory treatment. All patients survived. All patients underwent long-term clinical observation and follow–up and did not relapse. Therefore, AEBV + CT/NK-LH could elicit malignant features mimicking NK/T cell lymphoma pathologically and benign features mimicking IM clinically. The �ndings indicated that AEBV + CT/NK-LH should be taken into consideration as a potential diagnosis, thus further clinical information (such as age of onset [whether children and young people], nature of onset [whether sudden], disease course [whether short], symptoms [whether systemic], EBV infection status [whether acute], and lymph node involvement) is needed for accurate diagnosis and prognostic evaluation.
MECHANISM-BASED MODELING OF THE PHARMACODYNAMIC INTERACTION OF ALPHAXALONE AND MIDAZOLAM IN RATS

Running title: In vivo pharmacodynamic interaction of midazolam and alphaxalone Non-standard abbreviations used: PK/PD: pharmacokinetic-pharmacodynamic. EEG: electroencephalogram. HPLC: high performance liquid chromatography. Cl: total body clearance. Q: inter-compartmental clearance. V 1 and V 2 : volumes of distribution of compartment 1 and 2. V dss : volume of distribution at steady state. C max : maximal reached concentration in plasma. determining steepness of parabola. A: constant that accounts for the variation in baseline into parameter a. b: stimulus intensity where the top of the parabola is reached. d: exponent determining the asymmetry of the parabola. AUE: area under effect curve. MVOF: minimum value of objective function. This article has not been copyedited and formatted. The final version may differ from this version. ABSTRACT The objective of the present investigation was to characterize the pharmacodynamic interaction between the synthetic neuroactive steroid alphaxalone and the benzodiazepine midazolam. The time-course of the EEG effect (11.5-30 Hz) was determined in rats in conjunction with plasma concentrations. Alphaxalone was administered as a continuous intravenous infusion of 0, 1.2, 2.2 or 5.2 mg over 360 min. Midazolam was administered as a 5 min intravenous bolus infusion of 4 mg·kg-1. The pharmacokinetic profiles of both drugs were described by a 2-compartment model. No pharmacokinetic interaction was observed. The EEG effect vs. time profiles of midazolam and alphaxalone, when administered separately and in combination, were modeled on the basis of the recently proposed mechanism-based PK/PD model for GABA A receptor modulators, which contains separate expressions to describe the drug-receptor interaction and the stimulus-response relationship. The pharmacodynamic interaction between alphaxalone and midazolam was best characterized using an independent drug-drug interaction model without an expression for allosteric modulation of the effect of midazolam by alphaxalone. The final model contained an exponential expression to account for acute functional adaptation to the EEG effect upon continuous infusion of alphaxalone. The mechanism-based analysis showed that this functional adaptation is best explained by a change in the system-specific stimulus-response relationship, rather than the drug-receptor activation process. It is concluded that the pharmacodynamic interaction between alphaxalone and midazolam in vivo is best described using an independent interaction model without allosteric modulation. This article has not been copyedited and formatted. The final version may differ from this version. Recently, a mechanism-based pharmacokinetic-pharmacodynamic (PK/PD) model was developed for the electroencephalographic (EEG) effects of a wide array of GABA A receptor modulators including neuroactive steroids, benzodiazepines, imidazopyridines, cyclopyrrolones, …
Ultrasonic bone density measurement: A Biomedical Engineering Victory by a Medical Intervention

The broadband ultrasonic attenuation (BUA) and speed of sound (SOS) are commonly used to assess bone density. However, because earlier research has shown that the BUA is sensitive to movement and soft tissue, measurement repeatability will be challenging to obtain. Secondary osteoporosis is a significant co-morbidity associated with inflammatory rheumatic disorders that is caused by a variety of variables such as inflammatory cytokines, inactivity, and glucocorticoid medication. Because of its capacity to identify bone density as well as bone quality, quantitative ultrasonography (QUS) has been used in osteoporosis research. The purpose of this research is to look at the therapeutic potential of deep-sea water (DSW) for osteoporosis. We previously created ovariectomized senescence-accelerated mice (OVX-SAMP8) and demonstrated substantial osteoporosis healing using stem cells and platelet-rich plasma (PRP). The MTT assay revealed a considerable increase in osteoblastic cell (MC3T3) proliferation in deep sea water with a hardness (HD) of 1000. After a 4-month deep sea water therapy, bone mineral density (BMD) was dramatically raised, followed by significantly increased trabecular numbers by micro-CT examination, and biochemistry investigation revealed that blood alkaline phosphatase (ALP) activity was lowered. Bone marrow-derived stromal cells (BMSCs) were collected and studied for stage-specific osteogenesis. Workforce aging is becoming a major public health issue as a result of the growth of age-related disorders such as osteoporosis. Osteoporosis prevention and early identification are critical for avoiding bone fractures and their associated socioeconomic impact. Parkinson's disease (PD) is a prevalent neurological condition among the elderly, with a significant risk of falling. There is a lot of research on the link between Parkinson's disease and osteoporosis. The goal of this study is to use calcaneal ultrasound to describe the bone quality of a population with Parkinson's disease and compare it to a healthy control, while accounting for possible gender differences.
RESEARCH ARTICLE Antitumor Constituents from Anthriscus Sylvestris (L.) Hoffm

Bioassay-guided chemical investigation of the roots of Anthriscus sylvestris (L.) Hoffm. resulted in the isolation of nine compounds, whose structures were determined by spectroscopic methods. Compound 1 was isolated from this plant for the first time and compounds 3 and 9 were first found from this genus. Different polar fractions of A. sylvestris extract and compounds 1, 6-8 and 9 were evaluated for antitumor activities against HepG2 (human hepatocellular carcinoma), MG-63 (human osteosarcoma cells), B16 (melanoma cells) and HeLa (human cervical carcinoma cells) lines by the MTT method. The petroleum ether fraction of A. sylvestris extract exhibited excellent inhibitory activity with an IC 50 value of 18.3 μg/ml. Among the isolates from the petroleum ether fraction, compound 7 showed significant inhibition against the growth of the four tumor cells with IC 50 values ranging from 12.2-43.3 μg/ml.
behavior between

The aim of this in vitro study was to investigate the wear behavior of the abrader when tetragonal zirconia polycrystal (TZP), cp-titanium (CpTi) and Ti-6Al-4V alloy (TiAlV) were used for the antagonist on fixed dental prostheses. Both hemisphere abrader specimen and flat substrate specimens were prepared using TZP, CpTi and TiAlV. Two-body wear tests were performed in distilled water, and wear volume of the abrader specimen was measured to evaluate the wear behavior. In addition, a scanning microscopic observation and an electron probe micro-analysis were performed to elucidate the underlying mechanism of the wear. The wear volume of CpTi and TiAlV abrader specimen showed approximately twenty times larger than that of TZP abrader specimen against all substrate specimens. This is due to the differences in hardness between the ultra-hardness of TZP and comparatively low hardness of CpTi and TiAlV. The wear volume of CpTi and TiAlV abrader specimen against TZP substrate was significantly smaller than CpTi and TiAlV substrates despite the hardness of TZP was much larger than those of CpTi and TiAlV. This phenomenon may be based on the adhesive wear mechanism. Elements of Ti, Al and V originating in the TiAlV substrate were detected adhering to the abrader CpTi specimen. These results suggest that fixed dental prostheses of CpTi and TiAlV are susceptible to wear against not only TZP but also CpTi and TiAlV in contrast to TZP fixed dental prostheses.