Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of repetitive head trauma on symptomatology of subsequent sport-related concussion.

OBJECTIVE Adolescent participation in athletics continues to grow, leading to an increasing incidence of sports-related concussion (SRC). The current literature suggests that a greater number of prior concussions positively correlates with a greater number of total symptoms, but the specific concussion-related symptoms are not as well defined. The current study investigated the effects of prior recurrent head injury on the symptom profiles of student-athletes after another suspected concussion. METHODS A multicenter database consisting of 25,815 Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) results was filtered for student-athletes aged 12-22 years old who competed in 21 different sports. Patients were separated into 2 cohorts: athletes reporting a single prior concussion (SRC1) and athletes reporting 2 or more prior concussions (SRC2+). Comparisons were assessed for differences in 22 symptoms and 4 symptom clusters at baseline, first postinjury test (PI1), and second postinjury test (PI2) by using univariate and multivariate analyses. RESULTS No differences were seen between SRC1 (n = 2253) and SRC2+ (n = 976) at baseline. At PI1, the SRC2+ group (n = 286) had lower severity of headaches (p = 0.04) but increased nervousness (p = 0.042), irritability (p = 0.028), sadness (p = 0.028), visual problems (p = 0.04), and neuropsychiatric symptoms (p = 0.009) compared with SRC1 (n = 529). Multivariate analysis revealed decreased headache severity with increased prior concussion (β = -0.27,95% CI -0.45 to -0.09, p = 0.003). Multivariate analysis at PI2 demonstrated the SRC2+ cohort (n = 130) had increased cognitive (β = 1.22, 95% CI 0.27-2.18, p = 0.012), sleep (β = 0.63, 95% CI 0.17-1.08, p = 0.007), and neuropsychiatric (β = 0.67,95% CI 0.14-1.2,0.014) symptoms compared with SRC1 (n = 292). CONCLUSIONS At longitudinal follow-up, patients with a history of recurrent concussions reported greater symptom burden in cognitive, sleep, and neuropsychiatric symptom clusters but not migraine symptoms. This is an important distinction because migraine symptoms are often more easily distinguishable to patients, parents, and physicians. Careful assessment of specific symptoms should be considered in patients with a history of recurrent head injury prior to return to play.
Expansion of clinical and variant spectrum of EEF2‐related neurodevelopmental disorder: Report of two additional cases

Eukaryotic translation elongation factor 2 (eEF2), encoded by the gene EEF2, is an essential factor involved in the elongation phase of protein translation. A specific heterozygous missense variant (p.P596H) in EEF2 was originally identified in association with autosomal dominant adult‐onset spinocerebellar ataxia‐26 (SCA26). More recently, additional heterozygous missense variants in this gene have been described to cause a novel, childhood‐onset neurodevelopmental disorder with benign external hydrocephalus. Herein, we report two unrelated individuals with a similar gene‐disease correlation to support this latter observation. Patient 1 is a 7‐year‐old male with a previously reported, de novo missense variant (p.V28M) who has motor and speech delay, autism spectrum disorder, failure to thrive with relative macrocephaly, unilateral microphthalmia with coloboma and eczema. Patient 2 is a 4‐year‐old female with a novel de novo nonsense variant (p.Q145X) with motor and speech delay, hypotonia, macrocephaly with benign ventricular enlargement, and keratosis pilaris. These additional cases help to further expand the genotypic and phenotypic spectrum of this newly described EEF2‐related neurodevelopmental syndrome.
Characteristics Study on Time-Frequency Analysis Method Based on Empirical Mode Decomposition

For the limits of the conventional methods of time-frequency analysis, a novel method-Hilbert-Huang Transformation is analyzed. EMD/HS (Empirical Mode Decomposition/Hilbert Spectrum) algorithm which is used to extract instantaneous features of signals through utilizing the EMD and HT are proposed and its characteristics are analyzed, too. Simulation results show that, compared to conventional methods of time-frequency analysis, the method has perfect time-frequency concentration and eliminates the cross-time interference.
Drugs in Focus: Domperidone

Domperidone is a peripheral dopamine-2 receptor antagonist with prokinetic and antiemetic properties. Its prokinetic effects are mainly manifest in the upper gastrointestinal (GI) tract. Currently its use is restricted to relief of nausea and vomiting in children older than 12 years for a short period of time. However, among (pediatric) gastroenterologists, domperidone is also used outside its authorized indication (“off label”) for treatment of symptoms associated with gastro-esophageal reflux disease, dyspepsia, and gastroparesis. Little is known about its efficacy in the treatment of GI motility disorders in children and controversial data have emerged in the pediatric literature. As its use is off label, appropriate knowledge of its efficacy is helpful to support an “off label/on evidence” prescription. Based on this, the purpose of this review is to summarize all evidence on the efficacy of domperidone for the treatment of GI disorders in infants and children and to report an overview of its pharmacological properties and safety profile.
Determinants of Takāful and conventional insurance demand: A regional analysis

Abstract In this study, we focused on analysing and differentiating the determinants of conventional insurance and Takāful demand across ASEAN and Middle East Regions. We used panel data econometrics on a sample of 14 Asian countries having both conventional insurance and Takāful over the period 2005–2014. We applied fixed and random effect regression models to assess the impact of macroeconomic and demographic factors on conventional insurance and Takāful demand. Income and financial sector were found to have significant positive impact on insurance demand across all regions. On the other hand, dependency ratio was found to be negatively affecting Takāful demand across all regions while inflation shows positive impact. Urbanization was found to be significant positive impact on both conventional insurance and Takāful demand. Financial sector development positively triggers the insurance and Takāful demand across ASEAN region, while it triggers conventional insurance demand only in Middle East Region. Education shows negative impact on Takāful demand across both regions while it shows positive impact on insurance demand in Middle East. The study recognises the key role of urbanization and education in creating awareness to enhance Takāful demand in large populated countries of ASEAN and South Asia.
Lidar Observation of the Cirrus Cloud in the Tropopause at Chung-Li (25°N, 121°E)

Abstract The authors have detected a cirrus cloud near the tropopause by using a lidar system located at Chung-Li, Taiwan (25°N, 121°E). The cloud usually appeared between the month of May and September. In 1993–95, the cloud was observed almost 50% of the time that the lidar operated. The cloud was detected in the heights between 15 and 17 km; the region of the atmosphere had a temperature ranging between −70° and −83°C. It was never detected above the tropopause. The cloud was characterized by its very thin structure. The geometrical and optical thicknesses are about 0.6 km and 0.008, respectively, which can be considered as a subvisual cloud. This paper reports more than 20 cloud events observed in the years between 1993 and 1995. Some properties of the clouds are listed and compared with other references.
PANC Study (Pancreatitis: A National Cohort Study): national cohort study examining the first 30 days from presentation of acute pancreatitis in the UK

Abstract Background Acute pancreatitis is a common, yet complex, emergency surgical presentation. Multiple guidelines exist and management can vary significantly. The aim of this first UK, multicentre, prospective cohort study was to assess the variation in management of acute pancreatitis to guide resource planning and optimize treatment. Methods All patients aged greater than or equal to 18 years presenting with acute pancreatitis, as per the Atlanta criteria, from March to April 2021 were eligible for inclusion and followed up for 30 days. Anonymized data were uploaded to a secure electronic database in line with local governance approvals. Results A total of 113 hospitals contributed data on 2580 patients, with an equal sex distribution and a mean age of 57 years. The aetiology was gallstones in 50.6 per cent, with idiopathic the next most common (22.4 per cent). In addition to the 7.6 per cent with a diagnosis of chronic pancreatitis, 20.1 per cent of patients had a previous episode of acute pancreatitis. One in 20 patients were classed as having severe pancreatitis, as per the Atlanta criteria. The overall mortality rate was 2.3 per cent at 30 days, but rose to one in three in the severe group. Predictors of death included male sex, increased age, and frailty; previous acute pancreatitis and gallstones as aetiologies were protective. Smoking status and body mass index did not affect death. Conclusion Most patients presenting with acute pancreatitis have a mild, self-limiting disease. Rates of patients with idiopathic pancreatitis are high. Recurrent attacks of pancreatitis are common, but are likely to have reduced risk of death on subsequent admissions.
Distinct Alterations in Central Pain Processing of Visceral and Somatic Pain in Quiescent Ulcerative Colitis Compared to Irritable Bowel Syndrome and Health

Abstract Background and Aims Despite relevance to pain chronicity, disease burden, and treatment, mechanisms of pain perception for different types of acute pain remain incompletely understood in patients with inflammatory bowel disease [IBD]. Building on experimental research across pain modalities, we herein addressed behavioural and neural correlates of visceral versus somatic pain processing in women with quiescent ulcerative colitis [UC] compared to irritable bowel syndrome [IBS] as a patient control group and healthy women [HC]. Methods Thresholds for visceral and somatic pain were assessed with rectal distensions and cutaneous thermal pain, respectively. Using functional magnetic resonance imaging, neural and behavioural responses to individually calibrated and intensity-matched painful stimuli from both modalities were compared. Results Pain thresholds were comparable across groups, but visceral thresholds correlated with gastrointestinal symptom severity and chronic stress burden exclusively within UC. Upon experience of visceral and somatic pain, both control groups demonstrated enhanced visceral pain-induced neural activation and greater perceived pain intensity, whereas UC patients failed to differentiate between pain modalities at both behavioural and neural levels. Conclusions When confronted with acute pain from multiple bodily sites, UC patients’ responses are distinctly altered. Their failure to prioritise pain arising from the viscera may reflect a lack of adaptive behavioural flexibility, possibly resulting from long-lasting central effects of repeated intestinal inflammatory insults persisting during remission. The role of psychological factors, particularly chronic stress, in visceral sensitivity and disease-specific alterations in the response to acute pain call for dedicated mechanistic research as a basis for tailoring interventions for intestinal and extraintestinal pain symptoms in IBD.
A THREE-DIMENSIONAL STUDY OF THE HORIZONTAL VELOCITY DIVERGENCE

Abstract A three-dimensional picture of the horizontal velocity divergence is constructed at seven times, at twelve-hour intervals, with use of observed winds as a basis for divergence computations. No level of non-divergence is found; however, a surface of least divergence and a level of least divergence are located at each of the seven times, and their behavior is noted. A defense of the method includes comparison of vertical velocities computed by another method, and by the same method but with application of various types and degrees of smoothing. Principle conclusions are (1) that a surface of least divergence can be located but is not a physically significant surface, (2) that vertical velocities computed from the integrated low-level divergence correlate very well with the precipitation pattern, (3) that various kinds and degrees of smoothing do not appreciably change the order of magnitude of the divergence, and (4) that interesting diurnal variations in divergence intensity occur when values at 0.
Systematic Surveillance of an Emerging Picornavirus among Cattle and Sheep in China

We identified a novel picornavirus, boosepivirus, for the first time in China. Genetic evolutionary analysis revealed that NX20-1 strain was closely related to the Japanese strain Bo-12-38/2009/JPN and belonged to Boosepivirus B. ABSTRACT Emerging viruses are a constant threat to human and animal health. Boosepivirus is a novel picornavirus considered a gastrointestinal pathogen and has broken out in recent years. In 2020, we identified a strain of boosepivirus NX20-1 from Chinese calf feces and performed genetic characterization and evolutionary analysis. NX20-1 was closely related to the Japanese strain Bo-12-38/2009/JPN and belonged to Boosepivirus B. We found that 64 of 603 samples (10.6%) from 20 different provinces across the country were positive for boosepivirus by reverse transcription (RT)-PCR. Further, coinfection with other diarrheal pathogens was also present in 35 of these positive samples. Importantly, we found the prevalence of boosepivirus in sheep as well, indicating that Boosepivirus can infect different domestic animals. Our data suggest that boosepivirus is a potential diarrheal pathogen, but the pathogenicity and the mechanism of pathogenesis need further study. IMPORTANCE We identified a novel picornavirus, boosepivirus, for the first time in China. Genetic evolutionary analysis revealed that NX20-1 strain was closely related to the Japanese strain Bo-12-38/2009/JPN and belonged to Boosepivirus B. In addition, we found that the virus was prevalent in China with an overall positivity rate of 10.6% (64 of 603 samples), and there was significant coinfection with other pathogens. Importantly, we found the prevalence of boosepivirus in sheep as well, suggesting that boosepivirus has a risk of spillover and can be transmitted across species.
Less necessity of adjuvant S‐1 treatment in non‐monarchE‐eligible patients

In monarchE and Postoperative Therapy with Endocrine and TS‐1 (POTENT) trials, abemaciclib and S‐1 have, respectively, shown to be effective as adjuvant therapies for luminal breast cancer (BC), although whether patients who meet the criteria are at high risk of recurrence compared to non‐eligible patients is still unknown. Here, we investigated recurrence risk according to the criteria of each trial in Japanese patients.
An Iterative Method for Unsupervised Robust Anomaly Detection Under Data Contamination

Most deep anomaly detection models are based on learning normality from datasets due to the difficulty of defining abnormality by its diverse and inconsistent nature. Therefore, it has been a common practice to learn normality under the assumption that anomalous data are absent in a training dataset, which we call normality assumption. However, in practice, the normality assumption is often violated due to the nature of real data distributions that includes anomalous tails, i.e., a contaminated dataset. Thereby, the gap between the assumption and actual training data affects detrimentally in learning of an anomaly detection model. In this work, we propose a learning framework to reduce this gap and achieve better normality representation. Our key idea is to identify sample-wise normality and utilize it as an importance weight, which is updated iteratively during the training. Our framework is designed to be model-agnostic and hyperparameter insensitive so that it applies to a wide range of existing methods without careful parameter tuning. We apply our framework to three different representative approaches of deep anomaly detection that are classified into one-class classification-, probabilistic model-, and reconstruction-based approaches. In addition, we address the importance of a termination condition for iterative methods and propose a termination criterion inspired by the anomaly detection objective. We validate that our framework improves the robustness of the anomaly detection models under different levels of contamination ratios on five anomaly detection benchmark datasets and two image datasets. On various contaminated datasets, our framework improves the performance of three representative anomaly detection methods, measured by area under the ROC curve.
Tracing the origins of midlife despair: association of psychopathology during adolescence with a syndrome of despair-related maladies at midlife

Abstract Background Midlife adults are experiencing a crisis of deaths of despair (i.e. deaths from suicide, drug overdose, and alcohol-related liver disease). We tested the hypothesis that a syndrome of despair-related maladies at midlife is preceded by psychopathology during adolescence. Methods Participants are members of a representative cohort of 1037 individuals born in Dunedin, New Zealand in 1972–73 and followed to age 45 years, with 94% retention. Adolescent mental disorders were assessed in three diagnostic assessments at ages 11, 13, and 15 years. Indicators of despair-related maladies across four domains – suicidality, substance misuse, sleep problems, and pain – were assessed at age 45 using multi-modal measures including self-report, informant-report, and national register data. Results We identified and validated a syndrome of despair-related maladies at midlife involving suicidality, substance misuse, sleep problems, and pain. Adults who exhibited a more severe syndrome of despair-related maladies at midlife tended to have had early-onset emotional and behavioral disorders [β = 0.23, 95% CI (0.16–0.30), p < 0.001], even after adjusting for sex, childhood SES, and childhood IQ. A more pronounced midlife despair syndrome was observed among adults who, as adolescents, were diagnosed with a greater number of mental disorders [β = 0.26, 95% CI (0.19–0.33), p < 0.001]. Tests of diagnostic specificity revealed that associations generalized across different adolescent mental disorders. Conclusions Midlife adults who exhibited a more severe syndrome of despair-related maladies tended to have had psychopathology as adolescents. Prevention and treatment of adolescent psychopathology may mitigate despair-related maladies at midlife and ultimately reduce deaths of despair.
The Effects of Phonological Complexity on Past Tense Processing: An FMRI Study

BACKGROUND Behavioral dissociations between regular and irregular past tense morphology have been frequently observed. Such dissociations have been taken as evidence of the existence of separate mechanisms underlying the processing of regular and irregular verbs. In such dual mechanism accounts, the transformation of a regular verb stem into its past tense form is thought to involve the application of a set of rules whereas irregular past tense forms, which have been learned by rote, are retrieved through a lexical-associative memory mechanism [1,2]. However, behavioral dissociations may also be explained by an alternative, single-mechanism account. In this view, all verbs are processed through a single integrated system, but component processes within the network such as phonology and semantics have distinct representations within the system and may differentially contribute to the processing of individual words depending on multiple features of those words [3]. One feature that tends to distinguish regular and irregular verb forms is phonological complexity (PC). Because the transformation from present to past tense in regular verbs requires the addition of phonemes while this is rarely true in irregular forms, the inflection of regular verbs involves greater phonological demands and may therefore be more vulnerable to disruption with phonological impairment [4]. This theory has received support from a connectionist simulation [3] as well as a behavioral study in which regularity effects in patients with nonfluent aphasia were no longer evident when regular and irregular past tense forms were matched on PC [4]. In the current study, fMRI was used to examine activation patterns associated with regular and irregular past tense processing and to investigate the effect of PC on these patterns. We hypothesized that areas of greater activation for regular past tense processing would be minimized when regular and irregular past tense forms were matched on PC. Furthermore, we predicted that similar patterns of activation associated with PC would be seen when subjects were simply reading rather than generating past tense forms.
Visualizing Protein Localizations in Fixed Cells: Caveats and the Underlying Mechanisms

Fluorescence microscopy techniques have been widely adopted in biology for their ability to visualize the structure and dynamics of a wide range of cellular and subcellular processes. The specificity and sensitivity that these techniques afford have made them primary tools in the characterization of protein localizations within cells. Many of the fluorescence microscopy techniques require cells to be fixed via chemical or alternative methods before being imaged. However, some fixation methods have been found to induce the redistribution of particular proteins in the cell, resulting in artifacts in the characterization of protein localizations and functions under physiological conditions. Here, we review the ability of commonly used cell fixation methods to faithfully preserve the localizations of proteins that bind to chromatin, undergo liquid–liquid phase separation (LLPS), and are involved in the formation of various membrane-bound organelles. We also review the mechanisms underlying various fixation artifacts and discuss potential alternative fixation methods to minimize the artifacts while investigating different proteins and cellular structures. Overall, fixed-cell fluorescence microscopy is a very powerful tool in biomedical research; however, each experiment demands the careful selection of an appropriate fixation method to avoid potential artifacts and may benefit from live-cell imaging validation.
Attention relieves visual crowding: Dissociable effects of peripheral and central cues

Visual crowding can be reduced when attention is directed to the target by peripheral cues. However, it is unclear whether central cues relieve visual crowding to the same extent as peripheral cues. In this study, we combined the Posner cueing task and the crowding task to investigate the effect of exogenous and endogenous attention on crowding. In Experiment 1, five different stimulus-onset asychronies (SOAs) between the cue and the target and a predictive validity of 100% were adopted. Both attentional cues were shown to significantly reduce the effect of visual crowding, but the peripheral cue was more effective than the central cue. Furthermore, peripheral cues started to relieve visual crowding at the shortest SOA (100 ms), whereas central cues worked only at later SOAs (275 ms or above). When the predictive validity of the cue was decreased to 70% in Experiment 2, similar results to Experiment 1 were found, but the valid cue was less effective in reducing crowding than that in Experiment 1. In Experiment 3, when the predictive validity was decreased to 50%, a valid peripheral cue improved performance but a valid central cue did not, suggesting that endogenous attention but not exogenous attention can be voluntarily controlled when the cues are not predictive of the target's location. These findings collectively suggest that both peripheral and central cues can alleviate crowding, but they differ in terms of strength, time dynamics, and flexibility of voluntary control.