Miracle-dz/UniFAR-FTUs huggingface dataset:
Marriage and health: exploring the role of stress overload

ABSTRACT Background and Objectives The association between marital status and health is well-established, but its causes remain unclear. This study was the first to examine stress overload, the pathogenic form of stress, as a possible explanation. Design The study employed a cross-sectional design and convenience sample to explore relationships among stress overload, marital status, social support, and illness. Methods A diverse sample (n = 455), recruited from community and social media sites, completed an anonymous online survey. Included were standardized measures of stress overload (SOS-S), perceived social support (MSPSS), and somatic symptoms (PHQ-15). Results Married participants reported lower stress overload levels than those in any other type of relationship (single, in-a-relationship, or cohabiting). They did not differ from the unmarried in overall level of social support, nor did statistically controlling social support or income levels erase the stress overload differential. They also reported lower levels of symptomology than the unmarried. SEM analyses yielded a best-fitting model showing stress overload to partially mediate the link between marital status and symptoms. Conclusions Stress overload is one mechanism that explains the marital health disparity, albeit not the only one. This holds implications for future research and practice focused on personal relationships and well-being.
Reference intervals for erythrocyte parameters and hemoglobin electrophoresis parameters for young children in Guangxi

Erythrocyte parameter analysis is the important means for diagnosis and treatment of hematological diseases, which are essential for screening of thalassemia in southern China combined with hemoglobin electrophoresis analysis. But little is known regarding the reference intervals (RIs) in healthy pediatrics in these two areas.
Even-Odd Harmonious graphs

A graph G(V, E) with n vertices and m edges is said to be even-odd harmonious if there exists an injection f : V(G) ? { 1, 3, 5,…, 2n-1} such that the induced mapping f *:E(G) ? {0,2,4,…,2(m-1)} defined by f*(uv) = [f(u) + f(v)] (mod 2m) is a bijection. The function f is called even-odd harmonious labeling of G. In this paper, we prove that the bistar graph Bm,n, cycle with one pendent edge, crown graph, the graph K1,m,n. the prism graph C3Yn and the graph nP2 are even-odd harmonious graphs.
Contrasting phytoplankton-zooplankton distributions observed through autonomous platforms, in-situ optical sensors and discrete sampling

Plankton distributions are remarkably ‘patchy’ in the ocean. In this study, we investigated the contrasting phytoplankton-zooplankton distributions in relation to wind mixing events in waters around a biodiversity-rich island (Runde) located off the western coast of Norway. We used adaptive sampling from AUV and shipboard profiles of in-situ phytoplankton photo-physiology and particle identification (copepods, fecal pellets and the dinoflagellate Tripos spp.) and quantification using optical and imaging sensors. Additionally, traditional seawater and net sampling were collected for nutrient and in-vitro chlorophyll a concentrations and phytoplankton and meso-zooplankton abundances. Persistent strong wind conditions (~5 days) disrupted the stratification in offshore regions, while stratification and a subsurface chlorophyll maximum (SCM) were observed above the base of the mixed layer depth (MLD ~30 m) in inshore waters. Contrasting phytoplankton and zooplankton abundances were observed between inshore (with the presence of a SCM) and offshore waters (without the presence of a SCM). At the SCM, phytoplankton abundances (Tripos spp., the diatom Proboscia alata and other flagellates) were half (average of 200 cell L-1) of those observed offshore. On the contrary, meso-zooplankton counts were ~6× higher (732 ind m-3 for Calanus spp.) inshore (where a SCM was observed) compared to offshore areas. In parallel, fecal pellets and ammonium concentrations were high (>1000 ind m-3 for the upper 20 m) at the SCM, suggesting that the shallow mixed layer might have increased encounter rates and promoted strong grazing pressure. Low nutrient concentrations (< 1μM for nitrate) were found below the MLD (60 m) in offshore waters, suggesting that mixing and nutrient availability likely boosted phytoplankton abundances. The size of the absorption cross-section (σPII’) and yield of photosystem II photochemistry under ambient light (φPII’) changed according to depth, while the depth-related electron flow (JPII) was similar between regions, suggesting a high degree of community plasticity to changes in the light regime. Our results emphasize the importance of using multiple instrumentation, in addition to traditional seawater and net sampling for a holistic understanding of plankton distributions.
NCAPH promotes proliferation as well as motility of breast cancer cells by activating the PI3K/AKT pathway.

Objective This study aimed to assess the expression of NCAPH in human breast cancer, and to investigate its effects on breast cancer cells. Methods Bioinformation analysis was performed to analyze the expression of NCAPH in human breast cancer tissues and normal tissues in TCGA database. qPCR and Immunoblot assays were performed to clarify the expression of NCAPH in breast cancer tissues and cell lines, respectively. CCK-8, colony formation, FCM, transwell, and immunoblot assays were performed to reveal the effects of NCAPH on breast cancer proliferation, cell cycle, motility and EMT of breast cancer cells. Additionally, immunoblot assays were performed to investigate the effects of NCAPH on the PI3K/AKT pathway in breast cancer. Results We found that NCAPH was highly expressed in human breast cancer cell lines. The depletion of NCAPH suppressed the viability of breast cancer cells. Further, we noticed that its downregulation restrained breast cancer cell migration as well as invasion, and the EMT process. Mechanically, we noticed that NCAPH mediated the PI3K/AKT pathway, and therefore contributed to breast cancer progression. Conclusion In summary, NCAPH has the potential to serve as a breast cancer target.
Investigation of combined effects of propyl paraben and methyl paraben on the hypothalamic-pituitary-adrenal axis in male rats

The aim of this study was to investigate the endocrine-disrupting effects of methyl paraben (MeP) and propyl paraben (PrP) mixture on the hypothalamic-pituitary-adrenal axis (HPA). In this study, six experimental groups were designated. These groups included three control groups (control, corn oil control, and positive control (50 mg/kg/day BPA)) and three dose groups (10, 100, and 500 mg/kg/day MeP+PrP). MeP with PrP were mixed in a 1:1 ratio and administered to the 42-day-old male rats by oral gavage for 30 days. At the end of the experiment, adrenocorticotropic hormone (ACTH), corticosterone and aldosterone hormones were analyzed in serum. Effects of MeP+PrP on the adrenal glands were investigated by immunohistochemical staining of 11ß hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) enzymes involved in the synthesis steps of corticosterone and aldosterone. Also, pituitary and adrenal glands were examined histopathologically. In the histopathological findings, cortical nodule, congestion, and edema were found in the tissues. In the pituitary gland, cytokeratin rings were detected in all MeP+PrP dose groups, supporting the increase of corticosterone and ACTH. Serum corticosterone, aldosterone, and ACTH hormone levels were increased in the 100 mg/kg/day MeP+PrP and BPA groups. Results obtained from immunohistochemical staining showed that increased staining parallelled increased corticosterone and aldosterone hormone levels. In summary, the results showed that exposure to the MeP+PrP mixture caused a significant increase in ACTH and corticosterone. Also, the MeP+PrP mixture caused a significant increase of CYP11B1 and CYP11B2. MeP+PrP exposure disrupts the normal HPA axis.
Ultracellular Imaging of Bronchoalveolar Lavage from Young COVID-19 Patients with Comorbidities Showed Greater SARS-COV-2 Infection but Lesser Ultrastructural Damage Than the Older Patients

Abstract In this study, we examined the cellular infectivity and ultrastructural changes due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the various cells of bronchoalveolar fluid (BALF) from intubated patients of different age groups (≥60 years and <60 years) and with common comorbidities such as diabetes, liver and kidney diseases, and malignancies. BALF of 79 patients (38 cases >60 and 41 cases <60 years) were studied by light microscopy, immunofluorescence, scanning, and transmission electron microscopy to evaluate the ultrastructural changes in the ciliated epithelium, type II pneumocytes, macrophages, neutrophils, eosinophils, lymphocytes, and anucleated granulocytes. This study demonstrated relatively a greater infection and better preservation of subcellular structures in these cells from BALF of younger patients (<60 years compared with the older patients (≥60 years). The different cells of BALF from the patients without comorbidities showed higher viral load compared with the patients with comorbidities. Diabetic patients showed maximum ultrastructural damage in BALF cells in the comorbid group. This study highlights the comparative effect of SARS-CoV-2 infection on the different airway and inflammatory cells of BALF at the subcellular levels among older and younger patients and in patients with comorbid conditions.
Deep Reinforcement Learning for Control of Time-Varying Musculoskeletal Systems With High Fatigability: A Feasibility Study

Functional electrical stimulation (FES) can be used to restore motor function to people with paralysis caused by spinal cord injuries (SCIs). However, chronically-paralyzed FES-stimulated muscles can fatigue quickly, which may decrease FES controller performance. In this work, we explored the feasibility of using deep neural network (DNN) controllers trained with reinforcement learning (RL) to control FES of upper-limb muscles after SCI. We developed upper-limb biomechanical models that exhibited increased muscle fatigability, decreased muscle recovery, and decreased muscle strength, as observed in people with chronic SCIs. Simulations confirmed that controller training time and controller performance are impaired to varying degrees by muscle fatigability. Also, the simulations showed that large muscle strength asymmetries between opposing muscles can substantially impair controller performance. However, the results of this study suggest that controller performance for highly-fatigable musculoskeletal systems can be preserved by allowing for rest between movements. Overall, the results suggest that RL can be used to successfully train FES controllers, even for highly-fatigable musculoskeletal systems.
Endurance versus resistance training in treatment of cardiovascular risk factors: A randomized cross-over trial

Background Individual variability in traditional cardiovascular risk factor responses to different exercise modalities has not been directly addressed in humans using a randomized cross-over design. Methods Body weight and body mass index, resting blood pressure, blood glucose, insulin and lipids were assessed in 68 healthy untrained adults (26±6 years) who underwent three-months of exercise training targeted at improving cardiopulmonary fitness (endurance) and skeletal muscle function (resistance), separated by three-months washout. Results There were significant increases in weight and body mass index following resistance (+0.8 kg, P<0.01; and +0.26 kg/m2, P<0.01, respectively), but not endurance (+0.1 kg, P = 0.75; and +0.03 kg/m2, P = 0.70, respectively). Although no significant group changes resulted from training in other cardiovascular risk factors, the positive response rate for all variables ranged from 27–49% for resistance and 42–58% for endurance. Between 39–59% of individuals who did not respond to resistance nonetheless responded to endurance, and 28–54% who did not respond to endurance responded to resistance. Conclusion Whilst, on average, 12 weeks of resistance or endurance did not change most cardiovascular risk factors, many subjects showed robust positive responses. Exercise modality had an impact on the proportion of subjects who responded to training, and non-response to one mode of training did not imply non-response to the alternate mode. Although the effect of exercise on a single risk factor may be modest, the effect on overall cardiovascular risk profile can be dramatic. Study registration The study was registered at the Australian New Zealand Clinical Trials Registry, which was published prior to recruitment and randomization (ACTRN12616001095459).
Evolving and Incremental Value Iteration Schemes for Nonlinear Discrete-Time Zero-Sum Games

In this article, evolving and incremental value iteration (VI) frameworks are constructed to address the discrete-time zero-sum game problem. First, the evolving scheme means that the closed-loop system is regulated by using the evolving policy pair. During the control stage, we are committed to establishing the stability criterion in order to guarantee the availability of evolving policy pairs. Second, a novel incremental VI algorithm, which takes the historical information of the iterative process into account, is developed to solve the regulation and tracking problems for the nonlinear zero-sum game. Via introducing different incremental factors, it is highlighted that we can adjust the convergence rate of the iterative cost function sequence. Finally, two simulation examples, including linear and nonlinear systems, are conducted to demonstrate the performance and the validity of the proposed evolving and incremental VI schemes.
Fundamentals of Medical Ultrasonics

Introduction Definition of Sound A Brief History of Cavitation and Ultrasound Outline and Acknowledgements Stress, Strain and Elasticity The Uniform State of Stress Stress on an Inclined Plane Transformation of Stress for Rotation of Axes Principle Stress Stationary Values of Sheet Stress Octahedral Stresses Hydrostatic (Dilational) and Deviatoric Stress Tensors Strains and Displacements General Hooke's Law Equilibrium Equations for Three Dimensions Strain Compatibility Equations Plane Strain Plane Stress Polar Coordinates Stress Functions Stress Functions in Polar Coordinates Vibrations Mass on a Spring Free Vibrations Damped Free Vibrations Forced Vibrations Undamped Forced Vibrations Damped Forced Vibrations Nonlinear Springs Waves and Sound Wave Equation Speed of Sound in Air Solutions of the 1-Dimensional Wave Equation Sound Energy Point and Line Sources Doppler Effect Root-Mean-Square Pressure Superposition of Waves Beats Complex Representation of a Plane, Harmonic Wave Standing Wave Fourier Transform Decibel Scale Vectorial Notation for the Wave Equation Plane Waves in Isotropic Media Waves in Fluids Mechanisms of Attenuation Reflection and Transmission Scattering Nonlinear Propagation Transducers The Piezo-Effect Piezo Electric Materials Transducer Bandwidth Transducer Construction Radiated Fields Continuous Wave Excitation Transient Excitation Focussing Transducer Arrays Medical Imaging Standard Ultrasonic Imaging Modes Doppler Methods Special Techniques Artefacts Biological Effects of Ultrasound and Safety Regulations Bubble Physics Hollow Sphere Cavitation Threshold Fundamental Equation of Bubble Dynamics Pressure Radiated by a Bubble Viscous Fluids Oscillations Disruption Diffusion Radiation Forces Coalescence Jetting CEUS and Sonoporation Commercial Ultrasound Contrast Agents CEUS Some Non-Cardiac Imaging Applications Molecular Imaging Increased Drug Uptake Causes of Sonoporation Drug Carriers Gene Delivery Therapeutic News Anitbubbles Cell Death High-Intensity Focussed Ultrasound Concluding Remarks
Comparative Inhibitory Effects of Natural Biflavones from Ginkgo against Human CYP1B1 in Recombinant Enzymes and MCF-7 Cells

Abstract Human cytochrome P450 1B1 (CYP1B1) is an extrahepatic enzyme overexpressed in many tumors and associated with angiogenesis. Ginkgetin, isoginkgetin, sciadopitysin, and amentoflavone, the primary biflavones found in Ginkgo biloba , have excellent anti-inflammatory and anti-tumor effects. However, the effect of biflavones on CYP1B1 activities remains unknown. In this study, 7-ethoxyresorufin O-deethylation (EROD) was used to characterize the activities of CYP1 families. The impacts of four ginkgo biflavones on CYP1B1 activity and the cellular protein expression of CYP1B1 were systematically investigated. The results showed that amentoflavone with six hydroxyl substituents exhibited the most potent selective inhibitory effect on CYP1B1 activity with IC 50 of 0.054 µM in four biflavones. Sciadopitysin, with three hydroxyl and three methoxy substituents, had the weakest inhibitory activity against CYP1B1. Ginkgetin and isoginkgetin, both with four hydroxyl and two methoxy substituents, showed similar inhibitory intensity towards CYP1B1 with IC 50 values of 0.289 and 0.211 µM, respectively. Kinetic analysis showed that ginkgetin and amentoflavone inhibited CYP1B1 in a non-competitive mode, whereas sciadopitysin and isoginkgetin induced competitive or mixed types of inhibition. Notably, four ginkgo biflavones were also confirmed to suppress the protein expressions of CYP1B1 and AhR in MCF-7. Furthermore, molecular docking studies indicated more hydrogen bonds formed between amentoflavone and CYP1B1, which might explain the strongest inhibitory action towards CYP1B1. In summary, these findings suggested that biflavones remarkably inhibited both the activity and protein expression of CYP1B1 and the inhibitory activities enhanced with the increasing hydroxyl substitution, providing new insights into the anti-tumor potentials of biflavones.
Model theory : an introduction

This book is a modern introduction to model theory which stresses applications to algebra throughout the text. The first half of the book includes classical material on model construction techniques, type spaces, prime models, saturated models, countable models, and indiscernibles and their applications. The author also includes an introduction to stability theory beginning with Morley's Categoricity Theorem and concentrating on omega-stable theories. One significant aspect of this text is the inclusion of chapters on important topics not covered in other introductory texts, such as omega-stable groups and the geometry of strongly minimal sets. The author then goes on to illustrate how these ingredients are used in Hrushovski's applications to diophantine geometry. David Marker is Professor of Mathematics at the University of Illinois at Chicago. His main area of research involves mathematical logic and model theory, and their applications to algebra and geometry. This book was developed from a series of lectures given by the author at the Mathematical Sciences Research Institute in 1998.
Resveratrol Treatment of Autism Spectrum Disorder—A Pilot Study

Objectives Considering autism spectrum disorder (ASD) as a neurodevelopmental condition associated with immune system impairments, we aimed to evaluate the potential benefits, efficacy, tolerability, and safety of the anti-inflammatory, antioxidant, and neuroprotective trans-resveratrol (RSV) in behavioral impairments and in a set of 8 microRNAs (miR) related to the immune system in pediatric subjects with ASD. Methods This is an open-label pilot trial over a 3 months (90 days) study follow-up period designed to assess the effect of 200 mg/d RSV on 5 boys aged 10 to 13 (11.8 ± 1.1) years diagnosed with ASD according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Results The RSV treatment significantly reduced the Aberrant Behavior Checklist total score (P = 0.042) and Irritability (P = 0.041), with no alteration in Stereotypical Behavior (P = 0.066), Hyperactivity (P = 0.068), and Lethargy/Social Withdrawal (P = 0.078) subscales. On the Clinical Global Impression scale, 3 individuals showed marked improvement in behavior; one showed mild improvement, and the other had no changes. The RSV treatment increased the miR-195-5p (P = 0.043), an important modulator of targets related to inflammatory and immunological pathways. RSV administration did not present adverse effects and did not alter clinical laboratory results. Conclusions RSV is a safe molecule for administrating in the pediatric population, able to modulate behavior alterations and molecules associated with the immune system, becoming a promising therapeutic strategy for large-scale studies in ASD, to investigate both behavioral and molecular approaches.
Clinical pharmacology of antiplatelet drugs

ABSTRACT Introduction Platelets play a key role in arterial thrombosis and antiplatelet therapy is pivotal in the treatment of cardiovascular disease. Current antiplatelet drugs target different pathways of platelet activation and show specific pharmacodynamic and pharmacokinetic characteristics, implicating clinically relevant drug–drug interactions. Areas covered This article reviews the role of platelets in hemostasis and cardiovascular thrombosis, and discusses the key pharmacodynamics, drug–drug interactions and reversal strategies of clinically used antiplatelet drugs. Expert opinion Antiplatelet therapies target distinct pathways of platelet activation: thromboxane A2 synthesis, adenosine diphosphate-mediated signaling, integrin αIIbβ3 (GPIIb/IIIa), thrombin-mediated platelet activation via the PAR1 receptor and phosphodiesterases. Key clinical drug–drug interactions of antiplatelet agents involve acetylsalicylic acid – ibuprofen, clopidogrel – omeprazole, and morphine – oral P2Y12 inhibitors, all of which lead to an attenuated antiplatelet effect. Platelet function and genetic testing and the use of scores (ARC-HBR, PRECISE-DAPT, ESC ischemic risk definition) may contribute to a more tailored antiplatelet therapy. High on-treatment platelet reactivity presents a key problem in the acute management of ST-elevation myocardial infarction (STEMI). A treatment strategy involving early initiation of an intravenous antiplatelet agent may be able to bridge the gap of insufficient platelet inhibition in high ischemic risk patients with STEMI.
BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis

Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease. BAF60c, a unique subunit of the SWItch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex, is critical for cardiac and skeletal myogenesis, yet little is known about its function in the vasculature and, specifically, in AAA pathogenesis. Here, we found that BAF60c was downregulated in human and mouse AAA tissues, with primary staining to vascular smooth muscle cells (VSMCs), confirmed by single-cell RNA-sequencing. In vivo studies revealed that VSMC-specific knockout of Baf60c significantly aggravated both angiotensin II– (Ang II–) and elastase-induced AAA formation in mice, with a significant increase in elastin degradation, inflammatory cell infiltration, VSMC phenotypic switch, and apoptosis. In vitro studies showed that BAF60c knockdown in VSMCs resulted in loss of contractile phenotype, increased VSMC inflammation, and apoptosis. Mechanistically, we demonstrated that BAF60c preserved VSMC contractile phenotype by strengthening serum response factor (SRF) association with its coactivator P300 and the SWI/SNF complex and suppressing VSMC inflammation by promoting a repressive chromatin state of NF-κB target genes as well as preventing VSMC apoptosis through transcriptional activation of KLF5-dependent B cell lymphoma 2 (BCL2) expression. Our identification of the essential role of BAF60c in preserving VSMC homeostasis expands its therapeutic potential in preventing and treating AAA.