Miracle-dz/UniFAR-FTUs huggingface dataset:
Co-overexpression of RIOK1 and AKT1 as a prognostic risk factor in glioma

Glioblastoma multiforme (GBM) is one of the most frequent primary malignancies of the brain. Although the treatment strategy has significantly improved, patient prognosis remains poor. In vitro studies have shown that the right open reading frame kinase 1/protein kinase B (RIOK1-AKT) signaling pathway plays an important role in the malignant phenotype of glioma cells. This study aimed to investigate the co-expression of RIOK1 and ATK in glioma tissues and its clinical significance. Compared with normal tissues, RIOK1 and AKT1 expression were significantly upregulated in glioma tissues. In addition, patients with higher World Health Organization staging grades had increased RIOK1 and AKT1 expression levels, and RIOK1 and AKT1 expression were positively correlated. Notably, both RIOK1 and AKT1 expressions were correlated with poor prognosis. In vitro experiments showed that silencing RIOK1 inhibited the proliferation, migration, and invasion of glioma cell lines by suppressing AKT and c-Myc expression. These results indicate that the RIOK1-AKT1 axis could play an important role in GBM progression.
Effect of Ice Massage to Head and Spine on Blood Pressure and Heart Rate Variability in Patients with Hypertension: a Pilot Study

Background Ice massage is one of the common hydrotherapeutic procedures. The current study is first of its kind, conducted to evaluate the effect of ice massage to head and spine on blood pressure and heart rate variability in patients with hypertension. Materials and Methods Fifteen hypertensive subjects with the mean ± standard deviation (SD) age of 48.87 ± 11.17 yrs were recruited and underwent only one session of ice massage to head and spine for 20 min. Blood pressure and heart rate variability were assessed before and immediately after the intervention. Results Results of this study showed a significant reduction in systolic blood pressure (p = <.001), diastolic blood pressure (p < .001) and heart rate (p = .012), and a significant increase in R-R Interval (the intervals between adjacent R waves in the electro cardiogram) (p = .001) in the post-test assessments compared to its respective pre-test assessments. Conclusion Results suggest that 20 min of ice massage to head and spine may reduce blood pressure and heart rate in patients with hypertension. However, there is no evidence that this provides any significant clinical impact for the patient.
A NOVEL SEQUENTIAL AUCTION MECHANISM FOR RESOURCE ALLOCATION IN CLOUD

: Cloud computing is mainly focused on resource allocation, which requires studying the interactions between customers and cloud managers. However, the recent growth in customer's demands and the exposure of private cloud providers attract the cloud managers to rent extra resources from the CP's so as to handle their backlogged tasks. For the interactions between customers and cloud managers we adopt the options-based sequential auction (OBSA's) to design cloud resource allocation. as compared to previous work our paper can handle customers with heterogeneous demands, provide truthfulness as the dominant strategy, enjoy a simple winner determination procedure and prevent the delayed entrance issue. regarding the interactions between cloud managers and CP's, we provide two parallel markets for resource gathering. We conduct a comprehensive analysis of the two markets and identify the bidding strategies of the cloud managers.
The impact of organisational culture on occupational stress: Comparison of the SME IT sectors in India and the UK

The study's main aim is to examine the impact of organisational culture on occupational stress by comparing the IT sectors in India and the UK. The paper adopts the application of Denison’s model for studying the organisational culture, whereas role conflict, role ambiguity, role overload and role stress are considered to discuss occupational stress. Through snowball, convenience, purposive and quota sampling techniques, 62 respondents (31 from India and 31 from the UK) were targeted to attain a qualitative perspective through a semi-structured questionnaire. Results showed that there is an impact of organisational culture on occupational stress. Moreover, the impact is mainly evident in the Indian IT sector than the UK IT sector. Moreover, considering the impact of organisational culture on occupational stress, overall employees experience occupational stress, role overload, role conflict, role ambiguity and role stress. In contrasting economies, Indian IT sector employee’s experience role conflict, role overload, role ambiguity and role stress, whereas UK IT sector employees’ experience role ambiguity.
The challenges and opportunities of online learning during Covid-19 pandemic

challenges; Covid-19; digital migration methods; online learning; opportunities As the Covid-19 pandemic continues to spread over a year after the original outbreak, it is critical to have an open mind about the innovations Higher Education Institutions (HEIs) have implemented to keep teaching going, as they may help HEIs if appropriately implemented. The pandemic has caused many activities, including traditional educational activities, to be shut down. This has necessitated a vast wave of response migration for HEIs with Online Learning (OL) as the educational platform. This paper conducts desk research to review the challenges and opportunities of OL during Covid-19 pandemic. It was apparent that OL is different from emergency remote teaching, and as a result, OL is more justifiable. The unique aspects of the crisis response migration strategies of HEIs, teachers, and learners were discussed. Our findings offer insights for HEIs and especially educational managers, teachers, and learners to be aware of such challenges and opportunities to deal with them.
Impact of Integrating Science and Engineering Teaching Approach on Students Achievement: A Meta Analysis

STEM teaching approach has attracted the attention of science educators as a panacea in addressing the deteriorating interest in STEM learning. However, the impact of STEM teaching approach on students’ achievement is scarcely discussed. Thus, this study aimed to explore the impact of integrating Science and Engineering teaching approach on the achievement of students. This meta-analysis was conducted systematically on articles published between January 2000 to January 2020 which were retrieved from five databases (EBSCOhost, Emerald, Scopus, Web of Science and ERIC). Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were applied to ensure a rigorous selection of the desired research articles. The data were then assessed using two online statistical effect size calculators. A total of 14 effect sizes were calculated. The overall mean effect size obtained was of high effect (es=2.61). The Engineering Design Process (EDP)(es=3.26, high effect) was the most effective teaching approach in enhancing students’ understanding, as opposed to design-based learning. An implication of the study is that EDP should be the basis for other teaching approaches in SE. Solving and creating tasks encourage application of concepts that then lead to enhancement of achievement.
Long Cycle Life, Low Self‐Discharge Sodium–Selenium Batteries with High Selenium Loading and Suppressed Polyselenide Shuttling

The use of selenium as a cathode in rechargeable sodium–selenium batteries is hampered by low Se loading, inferior electrode kinetics, and polyselenide shuttling between the cathode and anode. Here a high‐performance sodium–selenium cell is presented by coupling a binder‐free, self‐interwoven carbon nanofiber–selenium cathode with a light‐weight carbon‐coated bifunctional separator. With this strategy, electrodes with a high Se mass loading (4.4 mg cm−2) render high reversible capacities of 599 mA h g−1 at 0.1C rate and 382 mA h g−1 at 5C rate. In addition, this novel cell offers good shelf‐life with a low self‐discharge, retaining 93.4% of its initial capacity even after resting for six months. As evidenced by experimental and density functional theory analysis, the remarkable dynamic (cycle life) and static (shelf‐life) stabilities originate from the high electrical conductivity, improved Na‐ion accessibility through the 3D interconnected open channels, and highly restrained polyselenide shuttle. The results demonstrate the viability of high‐performance sodium–selenium batteries with high selenium loading.
Synthesis of gold nanoparticles on multi-walled carbon nanotubes (Au-MWCNTs) via deposition precipitation method

Carbon nanotubes (CNTs) have received impressive consideration as support materials of noble metal catalysts in heterogeneous catalysis due to their good mechanical strength, large surface area and good durability under harsh conditions. The interaction between CNTs and noble metal nanoparticles (NPs) gives an unusual unique microstructure properties and or modification of the electron density of the noble metal clusters, and enhances the catalytic activity. In this study, the MWCNTs were first treated with a mixture of concentrated sulfuric and nitric acid by sonication to improve its dispersibility and to introduce the carboxylic (-COOH) groups on CNTs surfaces. Gold nanoparticles (Au NPs) on multiwalled carbon nanotubes (MWCNTs) were synthesized by the deposition precipitation (DP) method as this method is simpler, low cost, and excellent method. Then, the effect of reducing agent (NaBH4) on gold distribution on the support of MWCNTs was also studied. Dispersion test, Fourier Transform Infrared spectroscopy (FTIR) and Field Emission Scanning Electron Microscope (FESEM) are all used to characterize the functionalized MWCNTs (fCNTs) and the Au NPs-fCNTs catalyst. There are three important peaks in functionalized MWCNTs which correspond to C=O, O-H, and C-O absorption peaks, as a result of the oxidation of COOH groups on the surface of CNTs. The absorption band at 1717 cm−1 is corresponded to C=O stretching of COOH, while the absorption bands at 3384 cm−1 and 1011cm−1 are associated with O–H bending and C–O stretching, respectively. Surface morphology of Au NPs-fCNTs R4 and Au NPs- fCNTs WR catalyst by FESEM showed that the Au NPs of 19.22 ± 2.33 nm and 23.05 ± 2.57 nm size were successfully deposited on CNTs, respectively.Carbon nanotubes (CNTs) have received impressive consideration as support materials of noble metal catalysts in heterogeneous catalysis due to their good mechanical strength, large surface area and good durability under harsh conditions. The interaction between CNTs and noble metal nanoparticles (NPs) gives an unusual unique microstructure properties and or modification of the electron density of the noble metal clusters, and enhances the catalytic activity. In this study, the MWCNTs were first treated with a mixture of concentrated sulfuric and nitric acid by sonication to improve its dispersibility and to introduce the carboxylic (-COOH) groups on CNTs surfaces. Gold nanoparticles (Au NPs) on multiwalled carbon nanotubes (MWCNTs) were synthesized by the deposition precipitation (DP) method as this method is simpler, low cost, and excellent method. Then, the effect of reducing agent (NaBH4) on gold distribution on the support of MWCNTs was also studied. Dispersion test, Fourier Transform Infrared spectro.
MULTI-TEMPORAL IMAGE CO-REGISTRATION OF UAV BLOCKS: A COMPARISON OF DIFFERENT APPROACHES

Traditionally, data co-registration of survey epochs in photogrammetry relied on Ground Control Points (GCP) to keep the reference system unchanged. In the last years, Unmanned Aerial Systems (UAV) are increasingly used in photogrammetric environmental monitoring. The diffusion of affordable UAV platforms equipped with GNSS (Global Navigation Satellite System) centimetre-grade receivers might reduce, but not eliminate, the need for GCP. Conversely, if GNSS-assisted orientation cannot be used or if additional ground control and reliability checks are required, alternatives to repeated GCP survey have been proposed, taking advantage of Structure from Motion (SfM) photogrammetry. In particular, co-registering different epochs image blocks together, identifying corresponding features, has been demonstrated as a viable and efficient approach. In this paper four different strategies easily implementable in a generic commercial photogrammetric software are presented and compared considering three different test sites in Italy subject to different amounts of environmental changes. The influence of the amount and distribution of inter-epoch corresponding points on the accuracy of the reconstruction is investigated. The results show that some of the tested strategies obtains very good results and can be used (although not needed) also in RTK centimetre-grade UAV surveys, leveraging the additional information coming from previous epochs survey to actually increase the survey accuracy and reliability.
Rosuvastatin protects PC12 cells from hypoxia/reoxygenation-induced injury by inhibiting endoplasmic reticulum stress-induced apoptosis

The endoplasmic reticulum stress (ERS) response serves an important role in cerebral ischemia-reperfusion injury (CIRI). However, to the best of the our knowledge, the effect of rosuvastatin on the ERS response in CIRI has not yet been studied. In the present study, the effect of rosuvastatin on cell damage in CIRI was investigated; furthermore, the effect of rosuvastatin on the ERS response was explored. Firstly, a hypoxia/reoxygenation (H/R)-induced cell damage model was established in PC12 cells. Cell viability was subsequently detected by a Cell Counting Kit-8 assay. A lactate dehydrogenase kit was used to detect cytotoxicity. TUNEL assay was then used to measure the extent of cell apoptosis, and western blotting was used to analyze the expression levels of the apoptosis-associated proteins Bax, Bcl-2, cleaved caspase-3 and cleaved caspase-9. In addition, western blotting was used to detect the expression levels of ERS-associated proteins, including phosphorylated (p)-protein kinase R-like endoplasmic reticulum kinase (PERK), p-eukaryotic initiation factor 2α and other proteins. Treatment with rosuvastatin led to an increased activity of H/R-induced PC12 cells and a decrease in their cytotoxicity. Rosuvastatin also led to an inhibition in apoptosis and ERS in H/R-induced PC12 cells. After administration of the ERS response activator thapsigargin (TG), TG was found to reverse the protective effect of rosuvastatin on injury of H/R-induced PC12 cells. Taken together, these findings have shown that rosuvastatin is able to protect PC12 cells from H/R-induced injury via inhibiting ERS-induced apoptosis, providing a strong theoretical basis for the use of rosuvastatin in the clinical treatment of CIRI.
Effective Power Allocation Using for Transmit Source In MIMO Relay Communication

DOI: http://dx.doi. org/10.24018/ejece.2021. 5.3. 335 Vol 5 | Issue 3 | June 2021 75 Abstract — The Multiple Input Multiple Output (MIMO) systems using relays are of interest for high-speed radio communication systems. Currently, most of the articles are interested in the model of three nodes with purposes such as increasing the channel capacities (mutual information) or reducing the minimum mean square of error. This paper extends to more than one relay and is concerned with the maximum channel capacity. It is assumed that the channel matrices between source and relay as well as relay and receiver are random matrices; the relay precoders are also assumed to be random and known at the receiver. The article proposes that the Lagrange multiplier finding algorithm using the Newton – Raphson optimization method is more straightforward than the traditional finding algorithm using the first and second derivatives but still gives a higher channel capacity.
Seed Management and Quality of Farmer Saved Seeds of Bambara groundnut from North Western, Northern and Eastern Uganda

Bambara groundnut (BG) is a protein and energy-rich legume crop of African origin with the potential to contribute to food and nutrition security. There is limited information on seed management and quality of farmer saved seed of BG in Uganda. This study was conducted to investigate seed management practices and evaluate the quality of farmer saved seed from Uganda. Four hundred BG farmers were chosen using purposive sampling and information gathered on their seed management. A semi-structured questionnaire was used to interview the farmers. Seed colour and size determination, standard germination and electrical conductivity tests were done on seed samples collected from farmers. Results from survey revealed that farmers recycled seeds for more than 4 years (39.2%) and maintained mostly single landraces (52.5%). Seed was sun-dried on the ground (81%), stored in gunny bags (93.5%), and threshed mostly by hand (52.0%). Collected landraces had varied seed coat colours and significantly differed at p = 0.05 in their seed sizes, final germination percentage (FGP), electrical conductivity (EC), germination velocity index and seedling vigour index II (SVI-II). Local Bam landrace recorded highest SVI-II (485.3) and EC (0.52MSg-1) while TVSU 688 landrace recorded the highest FGP (96.0%) and lowest EC (0.06MSg-1).
Congenital heart defects and copy number variants associated with neurodevelopmental impairment

A genetic etiology is identifiable in 20%–30% of patients with congenital heart defects (CHD). Chromosomal microarray analysis (CMA) can detect copy number variants (CNV) associated with CHD. In previous studies, the diagnostic yield of postnatal CMA testing ranged from 4% to 28% in CHD patients. However, incidental pathogenic CNV and variants of unknown significance are often discovered without any known association with CHD. The study objective was to describe the rate of pathogenic CNV associated with neurodevelopmental impairment (NDI) and compare clinical findings in CHD neonates with genetic results. A single‐center retrospective review was performed on all consecutive newborns with CHD admitted to a tertiary neonatal intensive care unit from January 2013 to March 2019 (n = 525). CHD phenotypes were classified as per the National Birth Defect Prevention Study. CMA detected pathogenic CNV in 21.3% (61/287) of neonates, and karyotype or fluorescence in situ hybridization detected aneuploidies in an additional 11% of the overall cohort (58/525). Atrioventricular septal defects and conotruncal defects showed the highest diagnostic yield by CMA (28.6% and 27.2%, respectively). Among neonates with pathogenic CNV on CMA, 78.7% (48/61) were associated with NDI. Neonates with pathogenic CNV were smaller in length at birth compared to those with benign CNV or variants of unknown significance (p = 0.005) and were more likely to be discharged with an enteral feeding tube (p = 0.027). CMA can discover genetic variants associated with NDI and are common in neonates with CHD. Genetic testing in the neonatal period can heighten awareness of genetic risk for NDI.
Sleep disturbances and frailty status in older adults in Vietnam

This cross-sectional study aimed to describe sleep disturbance and its association with frailty syndrome among 903 older adults at the National Geriatric Hospital in Vietnam. Frailty was diagnosed according to the Fried criteria. Sleep disturbances was assessed based on the Pittsburgh Sleep Quality Index (PSQI). Of 903 patients, the mean age was 71.8 (SD = 8.5), and 537 (59.5%) were female. Most (96.7%) of the patients diagnosed with frailty had poor sleep; 95.3% had to get up at midnight or early morning; 93.3% could not sleep within 30 minutes; 86% had sleep efficiency less than 85%; 53.3% coughed at night; 50.7% had nightmares; and 27.3% and 22.7% of patients felt hot and cold, respectively. The majority (80.0%) of patients must get up to use the bathroom. In conclusion, most older adult diagnosed with frailty experienced at least one form of of sleep disturbance. Medical staffs should attend to the patient’s sleep quality, especially in patients with frailty.
EFFECT OF IN-OVO INJECTION OF BIOTIN, AND CARNITINE ON HATCHING AND GROWTH PERFORMANCE IN BROILER CHICKS

This study investigated the effect of injecting biotin, and carnitine in hatching eggs at four incubation times on hatchability traits and subsequent broiler chick’s performance. The eggs were injected with 0.1 ml biotin or carnitine compared to of saline (placebo control) at 1, 14, 16, 18 days of incubation. Thereafter, bird’s growth performance was monitored. The obtained results show that the highest fertile hatchability percent was achieved by saline water followed by biotin and carnitine injection. The best fertile hatchability percent recorded with the injection at day 18 followed by day 14, day 16 of incubation. Biotin followed by carnitine injection significantly improved final live body weight of chicks compared to saline water. Also, biotin injection significantly showed the best feed conversion ratio. Injection time had no significant effect on growth performance and carcass traits. It is suggested that the eggs injection with biotin or L-Carnitine at the day 18 th of incubation could improve hatchability and subsequent broiler growth performance.
Impact of lifestyle in prostate cancer patients. What should we do?

ABSTRACT Objective: This review aimed to analyze interventions raised within primary and tertiary prevention concerning the disease's incidence, progression, and recurrence of Prostate Cancer (PCa). Priority was given to the multidisciplinary approach of PCa patients with an emphasis on modifiable risk factors. Materials and Methods: We conducted a comprehensive literature review in the following databases: Embase, Central, and Medline. We included the most recent evidence assessing cohort studies, case-control studies, clinical trials, and systematic reviews published in the last five years. We only included studies in adults and in vitro or cell culture studies. The review was limited to English and Spanish articles. Results: Preventive interventions at all levels are the cornerstone of adherence to disease treatment and progression avoidance. The relationship in terms of healthy lifestyles is related to greater survival. The risk of developing cancer is associated to different eating habits, determined by geographic variations, possibly related to different genetic susceptibilities. Discussion: PCa is the second most common cancer in men, representing a leading cause of death among men in Latin America. Prevention strategies and healthy lifestyles are associated with higher survival rates in PCa patients. Also, screening for anxiety and the presence of symptoms related to mood disorders is essential in the patient's follow-up concerning their perception of the condition.
Addressing and Inspiring Vaccine Confidence in Black, Indigenous, and People of Color During the Coronavirus Disease 2019 Pandemic

Abstract During the coronavirus disease 2019 (COVID-19) pandemic, we have witnessed profound health inequities suffered by Black, Indigenous, and People of Color (BIPOC). These manifested as differential access to testing early in the pandemic, rates of severe disease and death 2–3 times higher than white Americans, and, now, significantly lower vaccine uptake compared with their share of the population affected by COVID-19. This article explores the impact of these COVID-19 inequities (and the underlying cause, structural racism) on vaccine acceptance in BIPOC populations, ways to establish trustworthiness of healthcare institutions, increase vaccine access for BIPOC communities, and inspire confidence in COVID-19 vaccines.