Miracle-dz/UniFAR-FTUs huggingface dataset:
RARGE II: An Integrated Phenotype Database of Arabidopsis Mutant Traits Using a Controlled Vocabulary

Arabidopsis thaliana is one of the most popular experimental plants. However, only 40% of its genes have at least one experimental Gene Ontology (GO) annotation assigned. Systematic observation of mutant phenotypes is an important technique for elucidating gene functions. Indeed, several large-scale phenotypic analyses have been performed and have generated phenotypic data sets from many Arabidopsis mutant lines and overexpressing lines, which are freely available online. Since each Arabidopsis mutant line database uses individual phenotype expression, the differences in the structured term sets used by each database make it difficult to compare data sets and make it impossible to search across databases. Therefore, we obtained publicly available information for a total of 66,209 Arabidopsis mutant lines, including loss-of-function (RATM and TARAPPER) and gain-of-function (AtFOX and OsFOX) lines, and integrated the phenotype data by mapping the descriptions onto Plant Ontology (PO) and Phenotypic Quality Ontology (PATO) terms. This approach made it possible to manage the four different phenotype databases as one large data set. Here, we report a publicly accessible web-based database, the RIKEN Arabidopsis Genome Encyclopedia II (RARGE II; http://rarge-v2.psc.riken.jp/), in which all of the data described in this study are included. Using the database, we demonstrated consistency (in terms of protein function) with a previous study and identified the presumed function of an unknown gene. We provide examples of AT1G21600, which is a subunit in the plastid-encoded RNA polymerase complex, and AT5G56980, which is related to the jasmonic acid signaling pathway.
Analysis of Relative Gene Expression Data Using Real-time Quantita- Tive Pcr and the 2 Preanalytic Error Tracking in a Laboratory Medicine Department: Results of a 1-year Experience

Anticancer Res 2003;23:3327–31. 4. Weikert S, Christoph F, Schrader M, Krause H, Miller K, Muller M. Quantitative analysis of survivin mRNA expression in urine and tumor tissue of bladder cancer patients and its potential relevance for disease detection and prognosis. Int J Cancer 2005;116:100–4. 5. Schultz IJ, Kiemeney LA, Karthaus HF, Witjes JA, Willems JL, Swinkels DW, et al. Survivin mRNA copy number in bladder washings predicts tumor recurrence in patients with superficial urothelial cell carcinomas. Clin Chem 2004;50:1425–8. 6. Acar H, Kilinc M, Yildirim MS, Kaynak M, Cenker A. Evaluation of chromosome 8 and 11 aneuploidies in washings and biopsy materials of bladder transitional cell carcinoma. Cancer Genet Cytogenet 2003;142:25–9. 7. Vet JA, Hessels D, Marras SA, van de Kaa CA, van der Poel HG, Michalides RJ, et al. Comparative analysis of p53 mutations in bladder washings and histologic specimens. Am J Clin Pathol 1998;110:647–52. 8. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2 C(T) method. Methods 2001;25:402–8.
Neurocognitive markers of suicidal ideation in patients with anxiety and mood disorders

Abstract Objective: This study aims at identifying associations between cognitive function and suicidal ideation in the sample of patients with anxiety and mood disorders (AMD). Methods: In sum, 186 (age = 39 ± 12.3 years; 142 [76.3%] females) patients with AMD were enrolled in the study. Assessment included evaluation of socio-demographic information, medication use, anxiety and depression symptoms. Cognitive tests included measures of psychomotor performance and incidental learning using the Digit Symbol Test. Trail Making Tests respectively measured perceptual speed, task-switching and executive control. Additionally, 21 patients completed tests from the Cambridge Automated Neuropsychological Test Battery measuring set shifting (Interdimensional/extradimensional set-shift), executive planning (Stockings of Cambridge), and decision making (Cambridge Gamble Task [CGT]). Results: Almost half (45.0%, n = 86) of the study sample patients had experienced suicidal ideations. In multivariable regression analysis, suicidal ideation was associated with a greater overall proportion of bet and risk taking on the CGT task (β = 0.726, p = .010 and β = 0.634, p = .019), when controlling for socio-demographic characteristics, medication use, anxiety and depression symptoms. Conclusions: Outpatients with AMD and suicidal ideation could be distinguished by the presence of cognitive deficits in the executive function domain, particularly in impulse-control and risk taking.
The range assignment problem in ad-hoc wireless networks : a survey

4 The Broadcast 10 4.1 Broadcast in the Line . 12 4.2 Broadcast in the Plane . 12 4.3 Broadcast in Higher Dimensions . 17 4.4 Open Problems . 18
Predicting Rare Disease of Patient by Using Infrequent Weighted Itemset

Mining association rule is a key issue in information mining. Nevertheless, the customary models overlook the differences among the trades, and the weighted association rule mining does not process on databases with simply binary attributes. Paper propose a novel frequent patterns and execute a tree (FP-tree) structure, which is an intensified prefix-tree structure for securing compacted, critical information about patterns, and make a capable FP-tree-based mining framework, FP improved function algorithm is utilized, for mining the complete arrangement of patterns by example frequent development. Here in this paper tackles the purpose of making extraordinary and weighted itemsets, i.e. infrequent weighted itemset mining problem. The two novel brilliance measures are proposed for figuring the infrequent weighted itemset mining issue. Moreover, the algorithm are tackled which perform IWI which is more negligible IWI mining. Additionally we used the infrequent itemset for decision based structure. The general problem of the beginning of dependable definite rules is difficult for the grounds that theoretically no provoking procedure without any other person can guarantee the rightness of affected theories. In this manner this system expects the sickness with the exceptional signs. Implementation study shows that proposed algorithm enhances the framework which is effective and adaptable for mining both long and short diagnostics rules. Framework enhances results of foreseeing rare diseases of patient.
EXPRESSION OF CD105 AND CD31 IN BENIGN AND MALIGNANT SALIVARY GLAND TUMORS WITH MYOEPITHELIAL DIFFERENTIATION (A COMPARATIVE STUDY).

Nadia Fathy Hassabou 1 , Rehab Fawzi Kasem 2 , Heba Ahmed Farag 3 and Nahed Emad El-Din Abo Azma 4 . 1. Assistant Lecturer, Oral Pathology Department, Faculty of Dentistry, October 6 University, Egypt. 2. Assistant Professor, Oral and Maxillofacial Pathology Department, Faculty of Dentistry, Cairo University, Egypt. 3. Professor, Oral and Maxillofacial Pathology Department, Faculty of Dentistry, Cairo University, Egypt 4. Professor, Oral Pathology Department, Faculty of Dentistry, Tanta University, Egypt. Manuscript Info Abstract . Manuscript History
Reductions in Platelet 18-kDa Translocator Protein Density Are Associated with Adult Separation Anxiety in Patients with Bipolar Disorder

Background: Recent studies indicate that adult separation anxiety disorder is a discrete diagnostic entity and worthy of attention. Previously, we found a significant association between platelet expression of the 18-kDa translocator protein (TSPO) and adult separation anxiety in patients with panic disorder or major depression. The aim of this study was to explore whether adult separation anxiety might be a factor differentiating TSPO expression in a sample of patients with bipolar disorder. Methods: The equilibrium binding parameters of the specific TSPO ligand [3H]PK 11195 were estimated on the platelet membranes of 24 adult outpatients with a DSM-IV diagnosis of bipolar disorder (with or without separation anxiety disorder) and 14 healthy controls. Patients were assessed by SCID-I, HAM-D, YMRS, the Structured Clinical Interview for Separation Anxiety Symptoms (SCI-SAS-A) and the Adult Separation Anxiety Self-Report Checklist (ASA-27). Results: A significant reduction in mean platelet TSPO density was found in bipolar patients with respect to controls. However, the lower density was only evident in the subgroup of bipolar patients who also fulfilled DSM-IV criteria for adult separation anxiety disorder. Individual TSPO density values correlated significantly and negatively with both SCI-SAS-A and ASA-27 total scores. Conclusions: TSPO expression may be a useful biological marker of adult separation anxiety co-occurring with other anxiety and mood disorders, including bipolar disorder.
Unconditionally stable methods for Hamilton--Jacobi equations

We present new numerical methods for constructing approximate solutions to the Cauchy problem for Hamilton-Jacobi equations of the form ut + H(Dxu)=0. The methods are based on dimensional splitting and front tracking for solving the associated (non-strictly hyperbolic) system of conservation laws pt + Dx H(p) = 0, where p = Dx u. In particular, our methods depend heavily on a front tracking method for one-dimensional scalar conservation laws with discontinuous coefficients. The proposed methods are unconditionally stable in the sense that the time step is not limited by the space discretization and they can be viewed as "large-time-step" Godunov-type (or front tracking) methods. We present several numerical examples illustrating the main features of the proposed methods. We also compare our methods with several methods from the literature.
Biochemistry of Legume Seed Proteins

BIOCHEMISTRY OF PROTEIN SYNTHESIS IN DEVELOPING SEEDS. 63 Transcription . 63 Translation . ; 64 Cell-/ree protein synthesis and correlation with in vivo activity . 64 Deposition of Storage Proteins. 66
From Cellulose to Cellulose Nanofibrils—A Comprehensive Review of the Preparation and Modification of Cellulose Nanofibrils

This review summarizes the preparation methods of cellulose nanofibrils (CNFs) and the progress in the research pertaining to their surface modification. Moreover, the preparation and surface modification of nanocellulose were comprehensively introduced based on the existing literature. The review focuses on the mechanical treatment of cellulose, the surface modification of fibrillated fibers during pretreatment, the surface modification of nanocellulose and the modification of CNFs and their functional application. In the past five years, research on cellulose nanofibrils has progressed with developments in nanomaterials research technology. The number of papers on nanocellulose alone has increased by six times. However, owing to its high energy consumption, high cost and challenging industrial production, the applications of nanocellulose remain limited. In addition, although nanofibrils exhibit strong biocompatibility and barrier and mechanical properties, their high hydrophilicity limits their practical application. Current research on cellulose nanofibrils has mainly focused on the industrial production of CNFs, their pretreatment and functional modification and their compatibility with other biomass materials. In the future, with the rapid development of modern science and technology, the demand for biodegradable biomass materials will continue to increase. Furthermore, research on bio-based nanomaterials is expected to advance in the direction of functionalization and popularization.
CS 221 Final Project Accelerating Symbolic Regression with Deep Learning

6 Analysis 7 6.1 Implementation and Hyperparameters . 7 6.1. 1 Encoder network . 7 6.1. 2 LSTM network . 7 6.2 Function Evaluation . 8 6.2. 1 Undetermined constants . 8 6.2. 2 Finding the constants . 8 6.2. 3 Syntax and heuristics . 8 6.2. 4 Training examples . 8
Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

The transdermal route of administration provides numerous advantages over conventional routes i.e., oral or injectable for the treatment of different diseases and cosmetics applications. The skin also works as a reservoir, thus deliver the penetrated drug for more extended periods in a sustained manner. It reduces toxicity and local irritation due to multiple sites for absorption and owes the option of avoiding systemic side effects. However, the transdermal route of delivery for many drugs is limited since very few drugs can be delivered at a viable rate using this route. The stratum corneum of skin works as an effective barrier, limiting most drugs’ penetration posing difficulty to cross through the skin. Fortunately, some non-invasive methods can significantly enhance the penetration of drugs through this barrier. The use of nanocarriers for increasing the range of available drugs for the transdermal delivery has emerged as a valuable and exciting alternative. Both the lipophilic and hydrophilic drugs can be delivered via a range of nanocarriers through the stratum corneum with the possibility of having local or systemic effects to treat various diseases. In this review, the skin structure and major obstacle for transdermal drug delivery, different nanocarriers used for transdermal delivery, i.e., nanoparticles, ethosomes, dendrimers, liposomes, etc., have been discussed. Some recent examples of the combination of nanocarrier and physical methods, including iontophoresis, ultrasound, laser, and microneedles, have also been discussed for improving the therapeutic efficacy of transdermal drugs. Limitations and future perspectives of nanocarriers for transdermal drug delivery have been summarized at the end of this manuscript.
Effect of Calcination Temperature and Chemical Composition of PAN-Derived Carbon Microfibers on N2, CO2, and CH4 Adsorption

This work investigates the interplay of carbonization temperature and the chemical composition of carbon microfibers (CMFs), and their impact on the equilibration time and adsorption of three molecules (N2, CO2, and CH4). PAN derived CMFs were synthesized by electrospinning and calcined at three distinct temperatures (600, 700 and 800 °C), which led to samples with different textural and chemical properties assessed by FTIR, TGA/DTA, XRD, Raman, TEM, XPS, and N2 adsorption. We examine why samples calcined at low/moderate temperatures (600 and 700 °C) show an open hysteresis loop in nitrogen adsorption/desorption isotherms at −196.15 °C. The equilibrium time in adsorption measurements is nearly the same for these samples, despite their distinct chemical compositions. Increasing the equilibrium time did not allow for the closure of the hysteresis loop, but by rising the analysis temperature this was achieved. By means of the isosteric enthalpy of adsorption measurements and ab initio calculations, adsorbent/adsorbate interactions for CO2, CH4 and N2 were found to be inversely proportional to the temperature of carbonization of the samples (CMF-600 > CMF-700 > CMF-800). The enhancement of adsorbent/adsorbate interaction at lower carbonization temperatures is directly related to the presence of nitrogen and oxygen functional groups on the surface of CMFs. Nonetheless, a higher concentration of heteroatoms also causes: (i) a reduction in the adsorption capacity of CO2 and CH4 and (ii) open hysteresis loops in N2 adsorption at cryogenic temperatures. Therefore, the calcination of PAN derived microfibers at temperatures above 800 °C is recommended, which results in materials with suitable micropore volume and a low content of surface heteroatoms, leading to high CO2 uptake while keeping acceptable selectivity with regards to CH4 and moderate adsorption enthalpies.
Stock Returns and Inflation Redux: An Explanation from Monetary Policy in Advanced and Emerging Markets

Classical theories of monetary economics predict that real stock returns are negatively correlated with inflation when monetary policy is countercyclical. Previous empirical studies mostly focus on a small group of developed countries or a few countries with hyperinflation. In this paper, I examine the stock return-inflation relation under different monetary policy regimes and conditions using an expanded dataset of 71 economies. Empirical evidence suggests that the stock return-inflation relation is partially driven by monetary policy. If a country’s monetary authority conducts a more countercyclical monetary policy, the stock return-inflation relation becomes more negative. In addition, the results differ by monetary policy framework. In exchange rate anchor countries, stock markets do not respond to monetary policy cyclicality. In inflation targeting countries, stock markets react more strongly to inflation. A key contribution of this paper is to classify inflation targeters by their behaviors, and illustrate that behavior matters in shaping market perceptions: markets react to inflation and monetary policy cyclicality when central banks are able to control inflation within their target bands. In this case markets are sensitive to inflation dynamics when inflation is above the announced target bands. Finally, when monetary policy is constrained by the Zero Lower Bound (ZLB), a structural break is introduced and real stock returns no longer respond to inflation and monetary policy cyclicality.
An analysis of airflow patterns in auxiliary ventilated drivages

In recent years the drivage advance rates achieved within the UK coal industry have increased. In the 1980's average drivage rates were 35m per week compared to the 100/150m per week possible today. These extended rates of advance have resulted in an increase in the potential methane, dust and heat generation within the vicinity of the drivage face. In order to effectively disperse this additional pollutant load a controlled increase in air quantity is required. Although advance rates have changed, current auxiliary ventilation practice has not. UK mining law requires that the fresh air must be delivered to within 5m of the face. This has lead to the wide spread adoption of the use of overlap auxiliary systems within mechanised drivages, since a pure forcing system set at this distance from the face would lead to excessive airborne dust. UK mining law does not at present consider on-board mounted exhaust scrubber fans to constitute an effective overlap fan within mechanised drivages. Consequently an additional overlap exhaust fan is required to be installed within such drivages. In an attempt to determine whether working conditions could be safely and economically improved within mechanised rapid development drivages utilising an on-board mounted exhaust fan, a series of preliminary full scale gallery trials were conducted. A summary of the principal findings of these trials is presented together with an outline of a series of representative CFD simulations. This thesis examines the accuracy of CFD simulations for auxiliary ventilated headings. This is achieved by utilising Laser Doppler Anenometry (LDA) in a scale model representative of an underground heading and a detailed underground measurement programme conducted in production headings. These measured airflow values are then compared with representative CFD simulations and conclusions
Effective design of blended MOOC environments in higher education

Over the past five years, Massive Open Online Courses (MOOCs) have a remarkable ability to expand access to a large scale of participants worldwide to attend free online courses, beyond the formality of the higher education systems. MOOCs have unique features that support a movement toward a vision of lifelong and on-demand learning for those who are working full time or have taken a break from formal education. Despite their popularity and the large scale participation, a variety of concerns and criticism in the use of MOOCs have been raised. The original concept of MOOCs that aims at breaking down obstacles to education for anyone, anywhere and at any time is far away from the reality. In fact, most MOOC implementations so far still follow a top-down, controlled, teacher-centered, and centralized learning model. Endeavors to implement bottom-up, student-centered, truly open, decentralized, and distributed forms of MOOCs are exceptions rather than the rule. Moreover, the lack of human interaction is the major limitation of the existing MOOCs. Other limitations of MOOCs include pedagogical problems concerning assessment and feedback, the lack of interactivity around the video content, as well as the complexity and diversity of MOOC participants. Furthermore, a major problem with MOOCs is the ignorance of the importance and benefits of face-toface communication. These limitations raise some serious concerns on what role MOOCs should play, or how they should fit into the higher education landscape as an alternative model of teaching and learning and a substantial supplement. Therefore, the aim of this dissertation is to shine new light to address these limitations. The new design paradigm of blended MOOCs (bMOOCs) that aim at bringing in-class (i.e. face-to-face) interactions and online learning components together as a blended environment can resolve some of the hurdles facing standalone MOOCs. In fact, the bMOOCs model has the potential to foster student-centered learning, provide effective assessment and feedback, support the interactive design of the video lectures, consider the different patterns of participants in the MOOC, as well as bring the benefits of face-toface interactions into the MOOC environment. This dissertation followed the case study research methodology and the user-centered design approach, in order to design, implement, and evaluate the LP-bMOOC platform. The main contributions are: a theoretical framework that compile and analyze the accumulated literature that has been conducted on Video-Based Learning and MOOCs between 2008 and 2015, a cluster of different patterns of MOOC stakeholders to build a deeper and better understanding of their behaviors, a design dimension and criteria catalogue for effective bMOOC environments, the conceptualization and implementation of the LP-bMOOC platform, an evaluation procedure for usability and effectiveness of bMOOCs, and opportunities for future work in the area of bMOOCs.
Interpreting Moderator Effects: Substitute for the Signed Coefficient Rule

Users of moderated multiple regression analyses often have used the "Signed Coefficient Rule" to interpret a moderator effect. This approach involves using the sign of the regression coefficient of the cross product term as an indication of the form of the relationship. Dissuading further use of the procedure, others advocated plotting techniques. In contrast, the present authors provide steps to interpret the form of moderator effects that can be achieved using only the regression coefficients of the predictor variable and interaction term.