Miracle-dz/UniFAR-FTUs huggingface dataset:
A Rare Case “Human Tail” Associated with Lipomeningocele and Tethered Cord

The human tail is perhaps the most exciting sign of a neural tube defect in the skin. From the appendix until creating a 20 cm long tail-like lesions are reported in this literature. They may occur associated with an underlying pathology condition such as a lipoma or teratoma, but mostly, they hide the underlying spinal dissrafism. Here, we are presenting a case of a 5-year-old female who presented with an 18-cm long tail, which the tail hid till this age because of social stigma and shame. This is the most extended human tail reported of our knowledge in Indonesia. Many classifications about the human tail have been suggested in history. However, regardless of the type, the primary approach to this lesson is always the same. They investigated the possibility of spinal dissrafism with pathology that occurs concurrently and planned treatment based on the patient. In neurosurgery, our goal is to determine the pathology that co-occurred accurately, fixes defects, and correct aesthetics so that the patient can be more confident and for the follow-up on pediatric patients regarding their development.
An Overview of Incretin-Based Therapies: Pharmacology and Future Perspectives

Glucagon-like peptide-1 (GLP-1) is a gut-derived incretin hormone that is released upon nutrient ingestion stimulating insulin secretion, suppressing glucagon secretion, and suppressing appetite and food intake which contribute to glucose homeostasis. The incretin system is impaired during type 2 diabetes mellitus (T2DM). Incretin-based therapies are gaining popularity in the clinical field nowadays. Current treatment guidelines for T2DM incorporate glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase 4 inhibitors (DPP-4i) as second-line agents with the advantages of low risk of hypoglycemia with good control of postprandial hyperglycemia (with short-acting GLP-1 RAs and DPP-4i) and weight loss (with GLP-1 RAs). GLP-1 RAs have more efficacy and are preferred with patients with preexisting cardiovascular disease. Growing evidence suggests that incretin-based therapies have beneficial effects on cardiovascular, liver, kidney, and nervous system disorders. The current review includes the biology of the incretin system, the pharmacology of incretinbased therapies, and their applications in experimental and clinical work.
Spatial hearing in middle-aged and older adults with a hearing aid: Does noise type matter?

Purpose: The present study aimed to identify the overall patterns of spatial hearing in a sample population of the geriatric population wearing a hearing aid in an actual clinical setting and to investigate while paying attention to aging and the effects of spatial separation on informational masking (IM) of target speech of common types of noise in everyday life.Methods: Nine participants (mean age: 68.9 ± 9.6) wearing hearing aids participated. The spatial hearing abilities of the participants were assessed by measuring their speech reception threshold (SRT) and spatial release from masking (SRM), using speech-like (SLN) and steady-state (SSN) noise-maskers.Results: The study results identified a trend in the decrease in SRT in all noise conditions with increasing azimuth angles. The larger the target/masker spatial separation, the larger the SRM became in all noise conditions. Results revealed that geriatric hearing-impaired participants experienced a comparable amount of SRM from IM in SLN concerning SSN.Conclusions: Given these findings, the spatial separation did not have the same effects on the IM of target speech by SLN in the geriatric population wearing a hearing aid as it did in the general hearing-impaired population at younger ages. It can be inferred from these findings that the extent to which informational maskers can compromise the spatial hearing abilities of geriatric hearing-impaired listeners may depend on their age and the severity of spatial hearing loss being imposed on them.
Multi-Level Correlates of the Nutritional Status of Nigerian Women of Reproductive Age

Poor nutrition compromises the capacity of women to perform their vital roles as mothers and productive workers in their families, communities and society. Using a conceptual framework developed by the United Nations Children’s Fund, this study determines individual-, household- and community-level factors associated with the nutritional status of Nigerian women of reproductive age. A secondary analysis of pooled data from the Nigeria Demographic and Health Survey (NDHS) for 2003, 2008, 2013 and 2018 was conducted involving 82,734 non-pregnant women aged 15–49 years. Multinomial logistic regression was used to determine predictors of nutritional status. Study results show that a significant proportion of the women had poor nutritional status; the prevalence of underweight, overweight and obesity were 12.1%, 16.8% and 7.2% respectively. Statistically significant factors associated with poor nutritional status were found at all three levels, highlighting the need for effective multidimensional, multisectoral policy interventions to address the double burden of malnutrition among women in Nigeria.
Sample paths of the solution to the fractional-colored stochastic heat equation

Let {u(t,x),t ∈ [0,T],x ∈ ℝd} be the solution to the linear stochastic heat equation driven by a fractional noise in time with correlated spatial structure. We study various path properties of the process u with respect to the time and to the space variable, respectively. In particular, we derive exact uniform moduli of continuity and Chung-type laws of iterated logarithm.
Bay and camphor leaf powders as inhibitors for hyperlipidemia and hepatotoxicity associated with industrial trans-fats consumption in male rats

Trans-fats are found in large numbers of food products as well as naturally in some animal sources in small amounts.Their consumption was associated with a lot of health problems. The main objective of this study was to investigate the hypolipidemic and hepatoprotective effects of bay and camphor leaf powders (BLP and CLP, respectively) in trans-fat enriched diet -fed rats. Thirty six adult male albino rats were used and divided into six equal groups, including the control group while groups 2 to 6 were fed for six weeks on trans-fats enriched diet(TFED, 12% hydrogenated vegetable fat) only (group 2), TFED containing 0.5 and 1 % of BLP (groups 3 and 4, respectively), or TFED containing 0.5 and 1 % of CLP (groups 5 and 6, respectively). At the end, body weight gain was calculated. Lipid profile, liver functions, pancreatic lipase and insulin levels were determined in sera, while cholesterol and phospholipids levels and oxidative stress markers were determined in liver tissue. Moreover, the histopathological examination of liver was performed and phenolic compounds in both powders were determined. Feeding TFED resulted in overweight, hyperlipidemia and liver dysfunction along with oxidative stress, which was confirmed histopathologically. Due to their content of phenolic compounds rather than other antioxidant agents, BLP and CLP exerted anti-obesity and hypolipidemic protective properties and alleviated the risky effects of TFED on hepatocytes. Thus, bay and camphor leaf powders can be considered efficient inhibitors for hyperlipidemia and hepatotoxicity associated with trans-fats consumption. Cinnamomum camphora leaf powders on hyperlipidemia and hepatotoxicity associated with industrial trans-fats consumption in vivo ;hence
Investigation of Outflow Boundary Conditions for Convection-Dominated Incompressible Fluid Flows in a Spectral Element Framework

In this thesis we implement and study the effects of different convective outflow boundary conditions for the high order spectral element solver Nek5000 in the context of solving convective-dominated fluid flow problems. By numerical testing we show that the convective boundary conditions preserve the spatial and temporal convergence rates of the solver. We also study highly convective test cases such as a single vortex propagating through the outflow boundary, and the typical Karman vortex shedding problem to analyze the accuracy and stability. A detailed comparison with the natural boundary condition that corresponds to the variational form of the incompressible Navier–Stokes equations (the Nek5000 “O” condition), and a stabilized version of it (by Dong et al. (2014)), are also presented. Our results show a major advantage of using the convective boundary conditions over the natural counterpart in solving convective problems, both according to stability and accuracy. Analytic and numerical results show that the natural condition has big stability problems for high Reynolds numbers, which make the use of stabilization methods or damping regions crucial. But, the (Dong) stabilized natural condition does not improve accuracy, and damping regions are computationally expensive. The convective conditions show very good accuracy if its convection speed is approximated accurately, and our results indicate that it can be used without damping regions efficiently. Our results also show that the magnitude of reflections significantly depends on the amplitude of the disturbances that move through the boundary. The convective boundary condition can handle large disturbances without producing significant reflections, while the natural one or a stabilized version of it in general can not.
Organising Australian far-right parties: Pauline Hanson’s One Nation and Fraser Anning’s Conservative National Party

ABSTRACT This paper analyses the organisation of two Australian far-right political parties: Fraser Anning’s Conservative National Party (FACNP) and Pauline Hanson’s One Nation (PHON). Based on semi-structured interviews with election candidates and office bearers and an analysis of official party documents, I examine how these parties manage their internal organisation and cope with problems of collective choice. I argue that their organisational practices are characterised by disorganisation. Namely, a lack of meaningful organisational structures and procedures, a core of socialised activists, andcoherent decision-making processes. By focusing on campaign mobilisation at the expense of party building, I argue that their disorganisation is inseparable from their muted electoral performance at the 2019 Australian federal election.
Biossurfactantes microbianos e aplicações ambientais: uma revisão narrativa

As indústrias petrolíferas são consideradas como os principais recursos energéticos, mas como produtoras simultaneamente de grandes quantidades de resíduos de hidrocarbonetos que são descartados em solo e na água. A contaminação por petróleo e derivados, incluindo os metais pesados, normalmente é tratada através de metodologias físicas, químicas ou biológicas. Assim, os biossurfactantes surgem como uma alternativa promissora para a remoção de petróleo e seus derivados devido à sua natureza anfipática, com porções hidrofílicas e hidrofóbicas permitindo que essas moléculas apresentem a capacidade de reduzir a tensão interfacial, de dispersar partículas de óleo, dispor de alta atividade superficial, possuir baixa toxicidade e elevada biodegradabilidade, de serem ecologicamente corretos, além de serem ativos sob condições extremas de salinidade, pH e temperatura. O presente estudo é uma revisão narrativa, que consiste em uma ampla análise da literatura. O objetivo deste trabalho é abordar o potencial de biossurfactantes microbianos em ser aplicados na biorremediação ambiental. As buscas dos artigos utilizados para compor este estudo foram realizadas em bases de dados científicos digitais, utilizando-se palavras-chave como biossurfactantes, óleo, petroderivados, biorremediação e metais pesados. Esta revisão fornece informações sobre as propriedades dos biossurfactantes, micro-organismos produtores, fatores nutricionais e a aplicação de biossurfactantes como uma alternativa favorável na remoção de petróleo e derivados, derramamento de óleo, limpeza de tubulações e de metais pesados.
Comparative Transcriptome Analysis Provides Novel Molecular Events for the Differentiation and Maturation of Hepatocytes during the Liver Development of Zebrafish

The liver plays an essential role in multiple biological functions including metabolism, detoxification, digestion, coagulation, and homeostasis in vertebrates. The specification and differentiation of embryonic hepatoblasts, the proliferation of hepatocytes, and the hepatic tissue architecture are well documented, but molecular events governing the maturation of hepatocytes during liver development remain largely unclear. In this study, we performed a comparative transcriptome analysis of hepatocytes that were sorted by flow cytometry from developing zebrafish embryos at 60, 72, and 96 hpf. We identified 667 up-regulated and 3640 down-regulated genes in hepatocytes between 60 and 72 hpf, 606 up-regulated and 3924 down-regulated genes between 60 and 96 hpf, and 1693 up-regulated genes and 1508 down-regulated genes between 72 and 96 hpf. GO enrichment analysis revealed that key biological processes, cellular components, and molecular functions in hepatocytes between 60 to 72 hpf, such as cell cycle, DNA replication, DNA repair, RNA processing, and transcription regulation, are mainly associated with the proliferation of hepatocytes. In addition to biological processes, cellular components, and molecular functions for cell proliferation, molecular functions for carbohydrate metabolism were enriched in hepatocytes during 72 to 96 hpf. KEGG enrichment analysis identified key signaling pathways, such as cell cycle, RNA degradation, ubiquitin-mediated proteolysis, ErbB and Hedgehog signaling, basal transcription factors, Wnt signaling, and glycan degradation, which are closely associated with cell proliferation or carbohydrate metabolism in hepatocytes between 60 to 72 hpf. Newly enriched signaling pathways in hepatocytes during 72 to 96 hpf include metabolisms of pyrimidine, purine, nicotinate and nicotinamide, caffeine, glycine, serine and threonine, ABC transporters, and p53 signaling that function in metabolisms of lipid, protein and energy, cellular secretion, or detoxification, indicating the functional maturation of hepatocytes between 72 to 96 hpf. These findings provide novel clues for further understanding the functional differentiation and maturation of hepatocytes during liver development.
PREDICTION OF TWO-PHASE FLOW IN SMALL TUBES: A SYSTEMATIC COMPARISON OF STATE-OF-THE-ART CMFD CODES

Multiphase dynamics and its characteristics for two-phase gas-liquid flow have been investigated by means of advanced numerical simulations. Although important in many engineering applications, methods for robust and accurate simulations for high density and viscosity ratios remain elusive. A comprehensive comparison of two state-of-the-art Computational Multi‐Fluid Dynamics (CMFD) codes, Fluent and TransAT, have been performed. The two commonly used methods for two‐phase flow simulations, namely Volume of Fluid implemented in Fluent and Level Set implemented in TransAT, could be compared as a result. Significant dierences were observed between the two flow topologies predicted by the two codes. For the bubbly flow case, a recirculating flow was predicted inside the bubbles by TransAT, meanwhile no significant recirculation was observed in the solution with Fluent. For the slug flow case a significant deviation was observed between the results from Fluent and TransAT on the slug formation and frequency. Periodic slug formation was observed with TransAT, in agreement with the experimental result of Chen et al. [4]. A periodic slug formation was not obtained with Fluent.
Mathematical modelling and numerical simulation in materials science

In a first part, we study numerical schemes using the finite-element method to discretize the Oldroyd-B system of equations, modelling a viscoelastic fluid under no flow boundary condition in a 2- or 3- dimensional bounded domain. The goal is to get schemes which are stable in the sense that they dissipate a free-energy, mimicking that way thermodynamical properties of dissipation similar to those actually identified for smooth solutions of the continuous model. This study adds to numerous previous ones about the instabilities observed in the numerical simulations of viscoelastic fluids (in particular those known as High Weissenberg Number Problems). To our knowledge, this is the first study that rigorously considers the numerical stability in the sense of an energy dissipation for Galerkin discretizations. In a second part, we adapt and use ideas of a numerical method initially developped in the works of Y. Maday, A.T. Patera et al., the reduced-basis method, in order to efficiently simulate some multiscale models. The principle is to numerically approximate each element of a parametrized family of complicate objects in a Hilbert space through the closest linear combination within the best linear subspace spanned by a few elementswell chosen inside the same parametrized family. We apply this principle to numerical problems linked : to the numerical homogenization of second-order elliptic equations, with two-scale oscillating diffusion coefficients, then ; to the propagation of uncertainty (computations of the mean and the variance) in an elliptic problem with stochastic coefficients (a bounded stochastic field in a boundary condition of third type), last ; to the Monte-Carlo computation of the expectations of numerous parametrized random variables, in particular functionals of parametrized Ito stochastic processes close to what is encountered in micro-macro models of polymeric fluids, with a control variate to reduce its variance. In each application, the goal of the reduced-basis approach is to speed up the computations without any loss of precision
The formation of interstellar jets

The formation of interstellar jets by convergence of supersonic conical flows and the further dynamical evolution of these jets are investigated theoretically by means of numerical simulations. The results are presented in extensive graphs and characterized in detail. Strong radiative cooling is shown to result in jets with Mach numbers 2.5-29 propagating to lengths 50-100 times their original widths, with condensation of swept-up interstellar matter at Mach 5 or greater. The characteristics of so-called molecular outflows are well reproduced by the simulations of low-Mach-number and quasi-adiabatic jets.
The Effect of Implementing Ischemic Stroke Nursing Management Protocol on Critical Care Nurses’ Knowledge and Practices

Background: Stroke is a medical emergency disease that affects millions of people worldwide annually. Early nursing interventions provided during the acute stage of ischemic stroke are essential in increasing survival rates and shaping patients’ long-term prognosis. Critical care nurses have a crucial role in providing high-quality care for ischemic stroke patients which can improve their clinical outcomes. Hence, they must have ongoing and periodical training programs about ischemic stroke nursing management. Aim: The study aimed to evaluate the effect of implementing the ischemic stroke nursing management protocol on critical care nurses’ knowledge and practices. Method: A quasi-experimental design was utilized on 56 critical care nurses who were working in the intensive care units affiliated with a University hospital in Egypt. Data were collected by using one tool: Nurses’ Knowledge and Practices Regarding Ischemic Stroke Nursing Management Protocol. Results: Highly statistically significant differences were found in nurses’ knowledge and practices pre and post the implementation of the ischemic stroke nursing management protocol (P<0.001). Conclusion: The implementation of the ischemic stroke nursing management protocol can improve nurses’ knowledge and practices regarding the care of ischemic stroke patients. Recommendations: Continuous in-service training programs on ischemic stroke management should be organized for critical care nurses to enhance their knowledge and practices, and keep them up-to-date and competent.
Spanning 36 years, the evolution and trend of word-of-mouth marketing research – based on bibliometrix analysis

: Word of mouth is an important influencing factor of customers' purchase decision-making behavior, and also a key basis for product promotion and improvement in business activities. Word of mouth marketing is a new tool of marketing, which has a special communication mechanism and characteristics, and is the main focus of business activity research. Based on the retrieval data of web of science, this study uses bibliometrix software to conduct network econometric analysis on 259 literatures on word-of-mouth marketing in the past 36 years. The research on word-of-mouth marketing is divided into three stages, focusing on the evolution of research topics and future development trends.
An Ultra-Compact Bidirectional Ka-Band Front-End Module With 3.8-dB NF and 13.5-dBm OP1 dB

This letter presents an ultra-compact bi-directional <inline-formula> <tex-math notation="LaTeX">$Ka$ </tex-math></inline-formula>-band front-end module (FEM) in 65-nm CMOS technology. In this design, the receiver (RX) path is stacked into the transmitter (TX) path by using a magnetic self-canceling technique, improving area efficiency greatly with negligible performance penalty. Furthermore, a three-inductor coupled resonator is elaborately designed to realize the functions of the balun and input–output matching network (MN) of the RX/TX simultaneously. The measurement results demonstrate that the proposed FEM achieves 18.2-dB peak gain with a 3.8-dB minimum noise figure (NF) in RX mode, and 26-dB peak gain with 13.5-dBm 1-dB compression output power (OP<inline-formula> <tex-math notation="LaTeX">$_{1\,{\mathrm {dB}}}$ </tex-math></inline-formula>) in TX mode. The core size of this proposed design is only 0.06 mm2 which is only 20%–50% of the size occupied in prior works.
Porcine Circovirus Type 2 Vaccines: Commercial Application and Research Advances

Porcine circovirus type 2 (PCV2) infection can lead to porcine circovirus-associated disease (PCVAD), causing great economic losses to the global swine industry. Conventional vaccination programs are a major measure in the prevention and control of this disease. Currently, there are 5 commercially available PCV2 vaccines in the international market and 10 kinds commercially available PCV2 vaccines in the Chinese market that confer good efficacy against this virus by alleviating clinicopathological manifestations and enhancing growth performance in pigs. In addition, diverse experimental PCV2 vaccines with protective efficiency have been developed, including attenuated chimeric, nucleic acid, subunit, multivalent, and viral-vectored vaccines. These experimental vaccines have been shown to be relatively effective in improving the efficiency of pig production and simplifying prevention procedures. Adjuvants can be used to promote vaccines with higher protective immunity. Herein, we review the application of multiple commercial vaccines over the years and research advances in experimental vaccines, which provide the possibility for the development of superior vaccines to successfully prevent and control PCV2 infection in the future.