Miracle-dz/UniFAR-FTUs huggingface dataset:
Nutrient and popping characteristics of Wyoming‐grown Peruvian popping beans

Abstract American consumers fall short of dietary fiber intake recommended by dietary guidelines. Beans provide protein and fiber, however, less than 14% of adults include them in their daily diets. Nuña beans (Phaseolus vulgaris L.), a class of common beans originated in South America and cultivated for growth in North America, possess a unique set of characteristics including flavor profile, popping ability, and nutrient content that may appeal to consumers. The purpose of this study was to evaluate a unique line of Wyoming‐grown popping beans to (1) determine nutrient characteristics and (2) assess popping percentage and shelf stability. Crude protein content was determined for five lines grown in Wyoming utilizing the Dumas method for nitrogen quantification. Total fatty acid content and a fatty acid profile for one line (CO49957) was determined by gas–liquid chromatography. Popping percentage was assessed by heating beans in canola oil in a cast iron pan to induce popping. Storage duration impact on popping was evaluated on CO49957 at 6, 12, and 15 months after harvest. Crude protein content was significantly different between all five lines. Total fatty acid content of CO49957 averaged 2.90 g/100 g wet weight. Average fatty acid profile of CO49957 popped in canola oil comprised oleic acid (41.4%), linoleic acid (20.4%), α‐linolenic acid (18.6%), palmitic acid (10.4%), and stearic acid (2.23%). Popping percentage was 90% (baseline), 100% (6 months), 87% (12 months), and 80% (15 months). Popping beans provide plant‐based protein and fiber while maintaining adequate levels of popping percentage with prolonged storage.
WSN Deployment Strategy for Real 3D Terrain Coverage Based on Greedy Algorithm with DEM Probability Coverage Model

The key to the study of node deployment in Wireless Sensor Networks (WSN) is to find the appropriate location of the WSN nodes and reduce the cost of network deployment while meeting the monitoring requirements in the covered area. This paper proposes a WSN node deployment algorithm based on real 3D terrain, which provides an effective solution to the surface-covering problem. First of all, actual geographic elevation data is adopted to conduct surface modeling. The model can vividly reflect the real terrain characteristics of the area to be deployed and make the deployment plan more visible and easy to adjust. Secondly, a probabilistic coverage model based on DEM (Digital Elevation Model) data is proposed. Based on the traditional spherical coverage model, the influence of signal attenuation and terrain occlusion on the coverage model is added to make the deployment model closer to reality. Finally, the Greedy algorithm based on grid scanning is used to deploy nodes. Simulation results show that the proposed algorithm can effectively improve the coverage rate, reduce the deployment cost, and reduce the time and space complexity in solving the WSN node deployment problem under the complex 3D land surface model, which verifies the effectiveness of the proposed algorithm.
Clinical applications of esophageal stents

Esophageal stents have been in surgical practice for over a century and continue to advance. Their use has led to changes in treatment paradigms and improved outcomes for a myriad of esophageal diseases. A variety of stents are used in the palliation of dysphagia in patients with malignant disease as well as part of a treatment plan in those with benign conditions. All stent placements begin with upper endoscopy in order to determine exact location of the pertinent pathology and use of a guidewire to set up for stent placement by the chosen technique. The type of stent chosen can vary based upon the etiology and presentation of each patient. In addition to stents that are commonly used today in management of patients, some of the newest developments in stent technology include 3D custom printed stents, biodegradable stents for benign strictures, or incorporating other therapeutic adjuncts to permit the slow-release of anti-cancer drugs. While complications during esophageal stent placement are rare, patients can experience bleeding or pain. These are generally self-limited. The most common complication is stent migration, which can be reduced with endoscopic fixation techniques. Much less common, but significantly more complex, is erosion through the esophagus. As surgical care continues to move towards less invasive approaches, endoscopic stent placement will continue to be a great option for numerous esophageal diseases. New opportunities for technological advancements are emerging that may further change current treatment algorithms for both malignant and benign pathologies. This may further give way to improved long-term outcomes or expansion of treatment options for patients.
Genetic Overlap Among Autism Spectrum Disorders and Other Neuropsychiatric Disorders

ABSTRACT Neuropsychiatric disorders such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), schizophrenia, bipolar disorder, and major depressive disorder tend to be classified as distinct entities. However, increasing evidence suggests that there are overlaps among these disorders in terms of their genetic risk factors. For example, chromosomal microdeletions and duplications in 16p11.2 have been reported in individuals with ASD as well as those with schizophrenia and intellectual disability, and common copy number variations have been reported in ASD, schizophrenia, and ADHD. Genome-wide association studies have also revealed common risk variants among ASD, ADHD, bipolar disorder, depression, and schizophrenia. Moreover, next-generation sequencing techniques have revealed overlap in de novo mutations among ASD, schizophrenia, and intellectual disability. Together, these results indicate that there are shared genetic risks across a range of different disorders. The findings from these studies converge on postsynaptic proteins, such as L-type calcium channels and proteins involved in N-methyl-D-aspartate signaling and indicate that synaptic mechanisms may underlie many different neuropsychiatric disorders, including ASD. Future studies are likely to reveal further shared mechanisms and contribute to the development of therapies for these disorders.
A utilização de antioxidantes orais na fotoproteção: revisão sistemática

A exposição excessiva à radiação solar é um dos principais contribuintes para o desenvolvimento do câncer de pele e fotoenvelhecimento. A fotoproteção oral tem sido utilizada como uma nova estratégia para o cuidado da pele, mesmo não sendo utilizada no lugar dos filtros solares tópicos ela pode agir de forma complementar a estes. Os antioxidantes orais parecem ser bons candidatos para reduzir os danos mediados pela radiação ultravioleta e prevenir as consequências para a saúde em razão da exposição excessiva. O objetivo deste estudo é revisar sistematicamente a utilização de antioxidantes orais na fotoproteção, identificando quais os principais antioxidantes orais existentes com evidências científicas comprovadas, evidenciando o mecanismo de ação de cada um deles, bem como demonstrar os possíveis efeitos no fotoenvelhecimento e câncer de pele. Para isso foi realizada uma pesquisa nas bases de dados: Science Direct, Pubmed, Scielo e Lilacs. Os critérios utilizados para a seleção dos artigos foram: artigos científicos relacionados com a temática em estudo, artigos disponíveis integralmente na internet, estudos pré-clínico in vitro e em animais (in vivo) e estudos clínicos em humanos. Um total de 16 artigos abordaram acerca de substâncias que possuem potenciais antioxidantes e que são candidatas a fornecer os efeitos fotoprotetores contra radiação UV. No entanto, não foi verificada nenhuma substância com evidência científica comprovada, quanto ao mecanismo de ação, foram encontradas poucas evidências e essas ainda são preliminares. E os efeitos antienvelhecimento e anticarcinogênico, nenhuma substância evidenciou a capacidade de atenuar estes danos.
The Effects And Possible Mechanisms of Vortioxetine on Pentylenetetrazole-Induced Seizures In Rats

Antidepressants are known to demonstrate various effects on the nervous system. As a new antidepressant, vortioxetine is used for major depression in adult patients, with no clear indication of epileptic seizures. Therefore, the aim here was to examine the impact of vortioxetine on pentylenetetrazole-induced epileptic seizures in rats. The rats were randomly divided into 5 groups, each with 6 rats. Group 1 was control, Group 2 was administered saline (1 mL/kg/day serum physiologic), Group 3 was given (1 mg/kg/day diazepam), and Groups 4 and 5 were administered vortioxetine (2.5 and 5 mg/kg/day). The experimental groups (Groups 2-5) were given the drugs for a total of 7 days. Pentylenetetrazole (45 mg/kg) was administered on day 7 to all but the control group. Behavioral testing was performed using the passive avoidance and open field tasks. Total antioxidant status (TAS), total oxidant status (TOS), tumour necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1 β), neuronal nitric oxide synthase (nNOS), nitric oxide (NO), soluble guanylate cyclase (sGC), cyclic guanosine monophosphate (cGMP) caspase-3, and caspase-9 levels were measured using a commercial kit. The groups receiving vortioxetine (2.5 mg/kg and 5 mg/kg) were found to have delayed epileptic seizure onset times and reduced seizure stages with improved memory impairment after seizures. These groups also had increased TAS levels and decreased TOS levels in the cortex and hippocampus. Additionally, TNF-α, IL-1 β, nNOS, sGC, cGMP, caspase-3, and caspase-9 levels in the cortex and hippocampus were statistically significantly lower for these groups. Vortioxetine was determined to have protective effects on pentylenetetrazole-induced seizures in rats, with alleviated seizures and improved memory impairment, oxidative stress, inflammation, and apoptosis. The mechanisms of vortioxetine may involve the inhibition of oxidative stress, inflammation, and the nNOS/sGC/cGMP signalling pathway.
Synthesis of 6,7-dihydro-4H-[1,2,3]triazolo[5,1-c][1,4]oxazines via tandem reactions of β-iodoazides with propargyl alcohols

Abstract Tandem reactions between β-iodoazides and propargyl alcohols under mild conditions are presented, providing a general and convenient method for the synthesis of 6,7-dihydro-4H-[1,2,3]triazolo[5,1-c][1,4]oxazines. The advantages of this method are its simple operation, high efficiency and high product yields (80–95%). Graphical Abstract
Cigarette Smoking Associated with Colorectal Cancer Survival: A Nationwide, Population-Based Cohort Study

We investigate whether cigarette smoking is associated with survival in patients with colorectal cancer (CRC) through a nationwide population-based cohort study in Taiwan. The Taiwan Cancer Registry and National Health Insurance Research Database were used to identify data from patients with CRC from 2011 to 2017. Tobacco use was evaluated based on the smoking status, intensity, and duration before cancer diagnosis. A total of 18,816 patients was included. A Kaplan–Meier survival analysis indicated smoking to be significantly associated with the CRC mortality risk (log-rank p = 0.0001). A multivariable Cox model indicated that smoking patients had a 1.11-fold higher mortality risk (HR = 1.11, 95% CI = 1.05–1.19) than nonsmoking patients did. This increased risk was also present in patients with CRC who smoked 11–20 cigarettes per day (HR = 1.16; 95% CI = 1.07–1.26) or smoked for >30 years (HR = 1.14; 95% CI = 1.04–1.25). Stratified analyses of sex and cancer subsites indicated that the effects of smoking were higher in male patients and in those with colon cancer. Our results indicate that cigarette smoking is significantly associated with poor survival in patients with CRC. An integrated smoking cessation campaign is warranted to prevent CRC mortality.
Understanding the people confined by the COVID-19 pandemic: a qualitative analysis (Comprendiendo a los confinados por el COVID-19: análisis cualitativo)

ABSTRACT On 15 March 2020, the Spanish population was obliged to confine at home, with no time to prepare. The objective of this study was to analyse the effects this confinement had on the population. 1,044 citizens (aged 16–84) agreed to participate. The study followed a phenomenological, qualitative research design, and a non-probabilistic snowball sampling was used to recruit the sample. Seven days after the confinement began, a questionnaire including one open question was distributed through social networks, email and the media to an initial wave of participants. They were asked to redistribute it among their contacts to reach a larger and less biased sample. Three positive topics emerged from the data: calm, hope/optimism and spirituality; and 11 negative topics: concern, weariness, stress/irritability, suspicion, anxiety, sadness, longing, indignation, pessimism, lonelinessand depression; and two that reflected both sides: emotional alternation and resignation. Because significant psychological consequences were observed (post-traumatic stress symptoms, confusion and anger), we believe monitoring the Spanish population’s mental health is necessary.
Performance Comparison of Hybrid Neuro-Fuzzy Models using Meta-Heuristic Algorithms for Short-Term Wind Speed Forecasting

In this paper, short-term wind speed forecasting models have been developed using neuro-fuzzy systems. The optimal neuro-fuzzy model has been investigated in detail. In addition, meta-heuristic algorithms, such as artificial bee colony differential evolution genetic algorithm and particle swarm optimization for training adaptive neuro-fuzzy inference systems parameters have been used in this study. This is a novel study, as four different meta- heuristic approaches are used to determine the appropriate adaptive neuro-fuzzy inference systems model parameters for short-term wind speed estimation, and analyzed comparatively. To validate the effectiveness of the proposed approach, wind speed series collected from a wind observation station located in Turkey are used in the short-term wind speed forecasting. In the first step, the results of analysis for finding the accurate model revealed that the optimal model that is proposed is adaptive neuro-fuzzy inference systems 7-1 architecture. The meta-heuristic algorithms used in the optimization of adaptive neuro-fuzzy inference systems model parameters are then independently run 10 times, and the performance results are calculated statistically for the training and test phases of the adaptive neuro-fuzzy inference systems model. The results of the study clearly show that the adaptive neuro-fuzzy inference systems-particle swarm optimization hybrid model has the best performance in the training aspect, but it is observed that the ANFIS-differential evolution hybrid model gives better results than the others in the test step.
Reachable set estimation and aperiodic sampled‐data controller design for Markovian jump systems

In this article, the problem of reachable set estimation (RSE) and aperiodic sampled‐data controller design are considered for Markovian jump systems (MJSs) with unit‐energy bounded disturbance and unit‐peak bounded disturbance inputs. First, by constructing mode‐dependent loop‐based Lyapunov functional, the linear matrix inequalities method is used to derive sufficient conditions for all states of MJSs under zero initial conditions to be bounded by ellipsoids. Second, RSE is considered in the process of designing the aperiodic sampled‐data controller. The objective is that the resulting ellipsoid comprises the reachable set of the closed‐loop system. Finally, the effectiveness of these methods is illustrated by the actual aircraft model and simulation results in this article. Furthermore, compared with other articles through numerical comparison, the method provided in this article can obtain less conservative results.
A. Siloti, a Piano Player and Music Teacher: Emigration from Russia and Peculiarities of Creative Activity in the USA (1921 to 1945)

The purpose of the study is to reveal three key vectors of activity of A. Siloti as an outstanding representative of the Russian emigre community during his residing in emigration in the USA. These are concert, teaching and editorial activities. A. Siloti belonged to the first, so-called post-October wave of emigration when arrived in the USA in 1921. The main reasons of his emigration were dangerous problems with Bolshevik`s power. He emigrated firstly to Finland, then were European counties, which were famous for Russian emigrants. After three years of wandering, which were marked by A. Siloti`s only concert activities he, at least, began his creative way in USA. So, this article specifies the contribution A. Siloti made both to the cultural environment of the USA at the beginning of the twentieth century, and to the performing and teaching activities of musicians of the first wave of emigration. The relevance of study is due to insufficient research on the activities of A. Siloti in emigration, and especially during his activities at the Juilliard music school. In this educational institution A. Siloti has begun working in 1925. Therefore, the first official information about his activities appeared only in connection with teaching activities at Juilliard. He cooperated with such famous concert collectives as New York Philharmonic Orchestra, Symphonic Orchestra in Sent-Louis, in Philadelphia and so on. That`s way, in this article were classified principles of A. Siloti`s pianism, which influenced on his pedagogical style. It is known from a small number of retained posters that some revisions were included in A. Siloti's concert programs, however they have not been considered as part of performing and interpretive analysis. According to analyze of A. Siloti`s concert posters and memoirs of his colleagues and students, the most part of his repertoire consist of his own editions. So, for making full picture of his emigration activities in this research is presented a detailed analysis of his editorial style on the such examples as Fantasia c-moll by J. S. Bach. Description of reasons for emigration, interpretive analysis of concert activities, as well as determination of the peculiarities of A. Siloti's teaching style in emigration and introduction of unpublished revisions of A. Siloti into scientific circulation provide for the relevance of research carried out in the framework of this article.
Complex neurovascular system in the dentary of Tyrannosaurus

ABSTRACT The morphology of the neurovascular canal in the jaw has been analysed in several fossil reptiles, including theropod dinosaurs. However, the details of the neurovascular canal in the dentary of theropods have not been fully elucidated. In this study, we described the well-preserved dentary of Tyrannosaurus rex, analysed the morphology of the neurovascular canal in the dentary using computed tomography techniques, and compared its distribution pattern with other dinosaurs and extant crocodiles. The results show that the neurovascular canal in the dentary of Tyrannosaurus exhibits a rather complex branching amongst the sampled dinosaurs, and that the complexity is comparable to that of extant crocodilians. The complexity of the canal branching is likely related to the high tactile sensitivity of the dentary, suggesting that the jaw tip of Tyrannosaurus may have played an essential role as a sensitive tactile sensor.
Listening to music to cope with everyday stressors

Everyday stressors—the irritating and disturbing events that happen in the context of everyday life—are common. The present research examined the relationship between everyday stressors and the use of music listening as a coping mechanism. In particular, it examined the use of music listening to cope with different types of everyday stressor and examined the relationship between this usage and listener characteristics, including demographics and music engagement style. Participants in the USA, Australia, and Malaysia (N =553) completed an online survey. A factor analysis was used to identify five types of everyday stressor: Social, Financial, Performance Responsibilities, Work-related, and Daily Displeasures. Individuals listened to music significantly more often to cope with social and work-related stressors than performance responsibilities and daily displeasures. Moreover, individuals who demonstrated a stronger affective listening style and those who reported listening to music for emotion/problem-orientated and avoidance/disengagement reasons were found to listen to music most often to cope with everyday stressors. These findings have implications, for both listeners and health professionals, when considering how music listening can be used as a self-administered tool for coping with everyday stressors.
When Fringe Hate Goes Mainstream: How White Nationalist Discourse Manifests in Online News Commenting

After protestors clashed in Charlottesville, Virginia over the planned removal of a statue of a Confederate general, President Trump refused to condemn white nationalists. Over the following days, numerous news stories were written about the protests, allowing the public to discuss white nationalism through online comments. Using theories on ideology, discourse, and framing, this study considers how white nationalist discourse emerged in those comments. The findings show broad support for white nationalism, including complaints about threats to white culture, reinterpretation of American history to support white nationalist ideas, and rejection of the idea that marginalized people face oppression. However, the study also shows a burgeoning force of critical commenters struggling to challenge white nationalism’s emergence in public spaces.
Isolated recurrence of acute myeloid leukemia in the cerebellum: illustrative case

BACKGROUND Myeloid sarcoma is a rare malignant hematopoietic neoplasm that arises at extramedullary sites. Although myeloid sarcoma may involve any organ, central nervous system (CNS) involvement is exceptionally rare. To date, few case reports and case series have described CNS myeloid sarcoma, the majority of which include peripheral disease. OBSERVATIONS The authors present an illustrative case of an adult male with acute myeloid leukemia (AML) in remission relapsing with an isolated, diffuse myeloid sarcoma of the cerebellum. Magnetic resonance imaging showed posterior fossa crowding and diffuse enhancement within the cerebellar white matter without an apparent mass lesion. The patient required ventriculostomy due to obstructive hydrocephalus and ultimately suboccipital craniectomy with duraplasty due to posterior fossa compression. An open cerebellar biopsy revealed myeloid sarcoma. Peripheral studies did not meet the criteria for recurrent AML. The patient subsequently received high-dose systemic chemotherapy and has responded well to treatment. LESSONS Myeloid sarcoma may be a neurosurgical lesion because it has the potential to cause mass effect with obstructive hydrocephalus requiring emergent cerebrospinal fluid diversion and possible decompression. The authors report a rare case of isolated recurrence of AML in the form of diffuse CNS myeloid sarcoma and describe the role of neurosurgery in its diagnosis and treatment.