Miracle-dz/UniFAR-FTUs huggingface dataset:
Title : Fission and fusion of plant mitochondria , and genome 7 maintenance 8 9

Plant Physiology; 1 2 Short title; Update on Mitochondrial dynamics 3 Corresponding Author: Shin-ichi Arimura, Graduate School of Agricultural and Life Sciences, 4 The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan 5 6 Title: Fission and fusion of plant mitochondria, and genome 7 maintenance 8 9 Author name; Shin-ichi Arimura 10 11 Affiliation; Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 12 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan 13 14 List of author contributions; S.A. conceived and wrote the article. 15 16 One sentence summary; Dynamic changes maintain a multipartite mitochondrial genome that 17 can better meet the changing needs of plant cells. 18 19 This work was supported by a grant from the Japan Society for the Promotion of Science (grant 20 no. 16K14827). 21 22 Corresponding author e-mail; arimura@mail.ecc. u-tokyo.ac. jp 23 24 In plant somatic cells, the number of mitochondria is usually larger than the copy 25 number of their genome. The constant fission and fusion of mitochondria make it possible to 26 share the internal materials between them (Arimura et al., 2004a). Therefore, the chondriome 27 (the collective mitochondria in a cell) is thought to exist as a discontinuous whole (Logan, 28 2006). In this update, I describe recent reports about mitochondrial dynamics during 29 developmental stages, in specific organs, and in environmental responses, the molecular 30 mechanisms underlying these dynamics, and relationship to their genome maintenances. Several 31 factors are involved in mitochondrial biogenesis, including gene expressions in the nucleus and 32 mitochondria and protein import from the cytosol to mitochondria. These processes are covered 33 in some excellent recent reviews (Czarna et al., 2016; Carrie et al., 2013; Law et al., 2014; 34 Millar et al., 2008). Here, I focus on recent investigations of the fission and fusion of plant 35 mitochondria, and its relatedness to their genome maintenance. 36 Mitochondria have an endosymbiotic origin in which they are thought to be 37 Plant Physiology Preview. Published on November 14, 2017, as DOI:10.1104/pp.17. 01025
Imatinib normalizes bone marrow vascularity in patients with chronic myeloid leukemia in first chronic phase

1. Gale KB, Ford AM, Repp R, et al. Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots. Proc Natl Acad Sci U S A. 1997;94:13950-13954. 2. Wiemels JL, Cazzaniga G, Daniotti M, et al. Prenatal origin of acute lymphoblastic leukemia in children. The Lancet. 1999;354:1499-1503. 3. McHale CM, Wiemels JL, Zhang L, et al. Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California. Genes Chromosomes Cancer. 2003;37:36-43. 4. Wiemels JL, Xiao Z, Buffler PA, et al. In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. Blood. 2002;99:3801-3805. 5. de The H, Chomienne C, Lanotte M, Degos L, Dejean A. The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. Nature. 1990;347:558-561. 6. Rowley JD, Golomb HM, Dougherty C. 15/17 translocation, a consistent chromosomal change in acute promyelocytic leukaemia. The Lancet. 1977;1:549550. 7. van der Reijden BA, Dauwerse JG, Wessels JW, et al. A gene for a myosin peptide is disrupted by the inv(16)(p13q22) in acute nonlymphocytic leukemia M4Eo. Blood. 1993;82:2948-2952. 8. Liu P, Tarle SA, Hajra A, et al. Fusion between transcription factor CBF beta/ PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science. 1993;261:1041-1044. 9. Castilla LH, Garrett L, Adya N, et al. The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia. Nat. Gen. 1999;23:144-146. 10. Grisolano JL, Wesselschmidt RL, Pelicci PG, Ley TJ. Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences. Blood. 1997;89:376-387.
INFERENCE OF PRIVACY POLICY FOR USER-UPLOADED IMAGES ON CONTENT SHARING SOCIAL SITES

Increasingly developed social sharing websites, like Flickr and YouTube, allow users to create, share, annotate and comment Medias. The large-scale user-generated meta-data not only facilitate users in sharing and organizing multimedia content, but provide useful information to improve media retrieval and management. Personalized search serves as one of such examples where the web search experience is improved by generating the returned list according to the modified user search intents. In this paper, we exploit the social annotations and propose a novel framework simultaneously considering the user and query relevance to learn to personalized image search. The basic premise is to embed the user preference and query-related search intent into user-specific topic spaces. Since the users’ original annotation is too sparse for topic modelling, we need to enrich users’ annotation pool before user specific topic spaces construction.
Stimulation of Callose Synthesis in Vivo Correlates with Changes in lntracellular Distribution of the Callose Synthase Activator ,&Furfuryl-P-Clucoside'

@-Furfuryl-8-glucoside (FG) has been shown to be a specific endogenous activator of higher plant callose synthase (P. Ohana, D.P. Delmer, C. Volman, J.C. Steffens, D.E. Matthews, M. Benziman [1992] Plant Physiol 98: 708-715). Because glycosides such as FG are usually sequestered in vacuoles, we have proposed that activation of callose synthesis in vivo may involve a change in the compartmentation of FG and CaZ+, resulting in a synergistic activation of callose synthase. The use of suspension-cultured barley (Hordeum bulbosum 1.) cells provides evidence that FG is largely sequestered in the vacuole. Furthermore, conditions that lead to induction of callose synthesis in vivo correspondingly lead to elevation of the cytoplasmic concentration of FC. These conditions include the lowering of cytoplasmic pH or elevation of cytoplasmic Caz+. Oligogalacturonide elicitors have also been reported to cause similar changes in cytoplasmic pH and CaZ+ concentration (Y. Mathieu, A. Kurkdjian, H. Xia, 1. Cuern, A. Koller, M.D. Spiro, M. O'Neill, P. Albersheim, A. Darvill [1991] The Plant Journal 1: 333-3431, and such an elicitor also causes an elevation in cytoplasmic FC coupled with stimulation of callose synthesis. These results support the concept that a relative redistribution of FC between cytoplasm and vacuole transduction pathway for elicitation of callose synthase in
NR 1 H 3 p . Arg 415 Gln is not associated to multiple sclerosis risk

A recent study by Wang et al. (2016a) claims that the low-frequency variant NR1H3 p.Arg415Gln is sufficient to cause multiple sclerosis in certain individuals and determines a patient’s likelihood of primary progressive disease. We sought to replicate this finding in the International MS Genetics Consortium (IMSGC) patient collection, which is 13-fold larger than the collection of Wang et al. (2016a), but we find no evidence that this variant is associated with either MS or disease subtype. Wang et al. (2016a) also report a common variant association in the region, which we show captures the association the IMSGC reported in 2013. Therefore, we conclude that the reported low-frequency association is a false positive, likely generated by insufficient sample size. The claim of NR1H3 mutations describing a Mendelian form of MS-of which no examples exist-can therefore not be substantiated by data. This Matters Arising paper is in response to Wang et al. (2016a), published in Neuron. See also the related Matters Arising paper by Minikel and MacArthur (2016) and the response by Wang et al. (2016b), published in this issue. DOI: https://doi.org/10.1016/j.neuron. 2016.09. 052 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-128616 Accepted Version Originally published at: Antel, J; Co I M S G; Martin, Roland; Sospedra, Mireia; Jelcic, Ilijas; International Multiple Sclerosis Genetics Consortium. Electronic (2016). NR1H3 p.Arg415Gln is not associated to multiple sclerosis risk. Neuron, 92(2):333-335. DOI: https://doi.org/10.1016/j.neuron. 2016.09. 052 Zurich Open Repository and Archive University of Zurich Main Library Strickhofstrasse 39 CH-8057 Zurich www.zora. uzh.ch
Enhancing Visual Quality in Wireless Capsule Endoscopy Images by using Contrast Enhancement Techniques

In this paper, primarily Contrast Limited Adaptive Histogram Equalization (CLAHE) technique is used to boost the visibility of local details of low contrast image by improving the contrast of its local regions. Next, wiener filter is used as smoothing filter. Then it is followed by contrast stretching which is used for adjusting the contrast of the image. Finally, unsharp filtering is used to sharpen the obtained image. This yields enhanced image which is useful for diagnosis. Keywords—CLAHE, wiener filter, contrast stretching and unsharp filtering etc.
Gastroprotective Mechanisms

Gastric ulcer (GU), a common type of peptic ulcer, results from an imbalance in the action of protective and aggressive agents. Gastroprotective mechanisms are mucus layer, gastric epithelium, gastric blood flow, gastric neurons, mucosal repair capacity, and immune system. Thus, the aim of this chapter was to provide an update on gastroprotective mechanisms. It was carried out through searches in PubMed covering the years 2016–2021 using several keywords. This survey resulted in 428 articles, of which 110 were cited in this chapter. It was reviewed the status of gastroprotective mechanisms and highlighted that mucins can act as a filter; gastric epithelial defenses are composed of the cell barrier, stem cells, and sensors on the mucosal surface; nitric oxide (NO) and hydrogen sulfide (H2S) act for gastric blood flow homeostasis (GBF); the main effector neurons in the gastric mucosa are cholinergic, nitrergic and VIPergic, and oxytocin can activate neurons; repair of the gastric mucosa requires complex biological responses; the immune system regulates the entry of antigens and pathogens. The main knowledge about gastroprotective mechanisms remains unchanged. However, we conclude that there has been progressing in this area.
DMD055566 700..706

The efflux transporter P-glycoprotein, expressed at high levels at the blood-brain barrier, exerts a profound effect on the disposition of various therapeutic compounds in the brain. A rapid and efficient modulation of this efflux transporter could enhance the distribution of its substrates and thereby improve central nervous system pharmacotherapies. This study explored the impact of the intravenous coadministration of two P-glycoprotein modulators, tariquidar and elacridar, on the pharmacokinetics and brain distribution of loperamide, a P-glycoprotein substrate probe, in rats. After 1 hour postdosing, tariquidar and elacridar, both at a dose of 1.0 mg/kg, increased loperamide levels in the brain by 2.3and 3.5-fold, respectively. However, the concurrent administration of both P-glycoprotein modulators, each at a dose of 0.5 mg/kg, increased loperamide levels in the brain by 5.8-fold and resulted in the most pronounced opioid-induced clinical signs. This phenomenon may be the result of a combined noncompetitive modulation by tariquidar and elacridar. Besides, the simultaneous administration of elacridar and tariquidar did not significantly modify the pharmacokinetic parameters of loperamide. This observation potentially allows the concurrent use of low but therapeutic doses of P-gp modulators to achieve full inhibitory effects.
Recent Advances of Active Infrared Thermography

Active infrared thermography is a fast and accurate non-destructive evaluation technique 10 that is of particular relevance to the aerospace industry for the inspection of aircraft and helicopters 11 primary and secondary structures, aero-engine parts, spacecraft components and its subsystems. 12 This review provides an exhaustive summary of most recent active thermographic methods used 13 for aerospace applications according to their physical principle and thermal excitation sources. 14 Besides traditional optically stimulated thermography, which uses external optical radiation such 15 as flashes, heaters and laser systems, novel hybrid thermographic techniques are also investigated. 16 These include ultrasonic stimulated thermography, which uses ultrasonic waves and the local 17 damage resonance effect to enhance the reliability and sensitivity to micro-cracks, eddy current 18 stimulated thermography, which uses cost-effective eddy current excitation to generate induction 19 heating, and microwave thermography, which uses electromagnetic radiation at the microwave 20 frequency bands to provide rapid detection of cracks and delamination. All these techniques are 21 here analysed and numerous examples are provided for different damage scenarios and aerospace 22 components in order to identify the strength and limitations of each thermographic technique. 23 Moreover, alternative strategies to current external thermal excitation sources, here named as 24 material-based thermography methods, are examined in this paper. These novel thermographic 25 techniques rely on thermoresistive internal heating and offer a fast, low power, accurate and reliable 26 assessment of damage in aerospace composites. 27
Effects of silage to concentrate ratio and duration of feeding on the fatty acid composition of ovine muscle and adipose tissue

Context. Dietary strategies may influence the fatty acid composition of sheep meat and ultimately its nutritional and sensory quality. Aim. This study investigated the effects of silage to concentrate ratio and feeding duration on the concentration of intramuscular fatty acids and branched chain fatty acid in subcutaneous adipose tissue of lambs. Methods. Pasture fed lambs were assigned in groups of 11 to one of nine dietary treatments consisting of silage to cereal concentrate at ratios (dry matter basis) of 100:0 (silage), 50:50 (silage:concentrate) or 0:100 (concentrate) for three feeding durations (36, 54 or 72 days) pre-slaughter. A 10th group of 11 lambs remained at pasture until slaughter. Fatty acid methyl esters were prepared using a microwave-assisted method and quantified by gas chromatography with flame ionisation detection. Results. The concentration of n-3 polyunsaturated fatty acids (PUFA) and proportions of C18:3n-3 and C18:2 cis-9 trans-11 decreased for mixed feed and/or concentrate treatments, but not for silage, from 36 to 72 days. The C18:2n-6 and n-6 PUFA concentrations increased for mixed feed and concentrate, but not for silage, from 36 to 72 days. The animals that remained at pasture had lower C18:2n-6 and n-6 PUFA than those receiving mixed feed for 72 days, concentrate for 54 days and concentrate for 72 days, but higher C18:3n-3, C18:2 cis-9 trans-11 and n-3 PUFA concentrations than the indoor finishing groups. The n-6/n-3 PUFA ratio was lower in pastured lambs compared to the other groups. 4-Methyloctanoic acid and 4-ethyloctanoic acid were higher in concentrate and mixed feed treatments than in silage while 4-methylnonanoic acid increased with increase in concentrate level in the diet. Conclusion. The ratio of silage to concentrate in the diet and duration of feeding pre-slaughter influence the fatty acid composition of muscle and subcutaneous adipose tissue of lambs. Implications. The results are important for lamb producers in understanding the nutritional and sensory implications of altering lamb diets.
CIA_A_205027 1021..1026

1Department of Anesthesiology and Pain Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea; 2Department of Anesthesiology and Pain Medicine, Catholic Kwandong University, College of Medicine, International ST. Mary’s Hospital, Incheon, Republic of Korea; 3Department of Anesthesiology and Pain Medine, Myongji Hospital, Hanyang University Medical Center, Seoul, Republic of Korea Purpose: Knee tibiofemoral osteoarthritis (KOA) is a major health problem, affecting
IMPLEMENTATION AND ANALYSIS OF CONGESTION PREVENTION AND FAULT TOLERANCE IN NETWORK ON CHIP

: As semiconductor technology has evolved, the convergence of a large series of processing cores on a single silicon chip known as a System on Chip (SoC) [1] has expanded substantially. With the increase in the applications for modern technology, the amount of computational power that can be handled on a single chip has greatly expanded. The Network on Chip (NoC) has successfully replaced the traditional bus-based mode of transportation in order to satisfy the SoC connectivity standards. NoC is an on-chip communication strategy aimed at reconciling inter-core and system messages in tandem. The NoCs are also scalable since, it overcomes network congestion, area utilization and operates at higher frequencies. Congestion is also a critical part of any wireless networks against packet loss and latency. This motivated us to design and implement a FPGA based router architecture for Network on Chip. The goal of this research paper is to efficiently propagate data packets to their intended destination and thereby, the network parameters such as area and transmission rate are considered to improve the performance of the network.
Low power CMOS full adder design with body biasing approach

ABSTRACT 1 In this paper, five different low power full adders using XOR/XNOR gates and multiplexer blocks with body biasing have been presented. In the first methodology, the adder depicts minimum power dissipation of 204. 09µW and delay of 5.9849 ns. In the second, an improvement in power consumption has been reported at 128. 92µW with delay of 5.9875 ns by using voltage biasing of two PMOS (P1 &P2) along with substrate biasing. In the third methodology, adder gives minimum power dissipation of 0.223nW with a delay of 5.2352 ns. Further, in fourth, it shows minimum power consumption of 0.199nW with a delay of 5.1002 ns and finally in fifth methodology, minimum power reduces to 0.192nW. Moreover, power delay product (PDP) results also have been compared for these methodologies. Comparisons have been made with earlier reported circuits and proposed circuits show better performance in terms of power consumption and delay.
U SING G LOBAL V IRTUAL T EAMS TO S UPPORT A S USTAINABILITY M INDSET IN E NGINEERING E DUCATION

– In an increasingly interconnected economy, future engineers require a sustainability mindset, which necessitates a global perspective, to enable them to work together with diverse partners to tackle the world’s problems in a sustainable manner. This study explores engineering students’ development of intercultural competencies within the context of culturally diverse global virtual team projects. We report on two consecutive iterations of an Intercultural Competency Module (ICM) delivered within a global virtual team project setting, in which engineering students are engaged in collaborative technical projects. Each study iteration comprised of a pre-survey to gain insights into student’s prior knowledge and cultural background and a post-survey to determine students’ perceptions of their intercultural learning and experiences. Employing a mixed-methods approach, we found that blending ICM with global virtual team projects was a successful approach for helping engineering students acquire international experience and develop intercultural competencies in addition to technical engineering knowledge.
Escaping the Hidden War Safety Is the Biggest Gain for CHA Families

to improve public housing by replacing failed developments with healthy and safe communities that offer a better quality of life for residents. In 1999, when the Chicago Housing Authority’s (CHA) Plan for Transformation began, the agency’s large family developments were notorious for being among the most dangerous places in the nation. Decades of failed federal policies, managerial incompetence, financial malfeasance, and basic neglect had left these developments in an advanced state of decay, with overwhelming crime and violence and near-absolute gang dominance. During the 1990s, the CHA had fought an all-out war against the drug trafficking and violence in its developments, spending $500 million on such efforts as law enforcement “sweeps” intended to remove drug dealers and gangs from its buildings, inhouse police and security forces, and tenant patrols, none of which had any lasting effect on the crime and disorder (Popkin et al. 2000). In 2001, before the HOPE VI redevelopment initiative began in Madden/Wells, respondents reported extreme problems with crime and disorder. Over 80 percent reported “big problems” with drug sales and drug use in their development and more than 70 percent reported “big problems” with shootings and violence. Residents’ perceptions were supported by official crime statistics; in 2001, reported violent crime in Madden/Wells was more than two times that for the rest of the city. The CHA’s plans for Madden/Wells called for demolishing the development and replacing it with a new mixed-income development called Oakwood Shores. By 2005, about 60 percent of Madden/ Wells respondents had been relocated, most to the private market with vouchers. Respondents who had moved out reported dramatically improved circumstances— the proportion of voucher holders reporting big problems with drugs and violent crime fell by about 50 percentage points. However, the respondents still living in their original units in 2005 were living in conditions just as bad as in 2001. Indeed, circumstances were possibly worse; more than half of the development was empty and, according to respondents, gangs and drug dealers from recently closed Escaping the Hidden War Safety Is the Biggest Gain for CHA Families
Low dimensional semiconductor structures : characterization, modeling and applications

Advances in Low Dimensional Semiconductor Structures. - Modeling of Low Dimensional Semiconductors. - Graphene: Properties and Theory. - Functionalization of Graphene Nanoribbons. - Atom/Molecule Van Der Waals Interaction with Graphene. - Optical Studies of Semiconductor Quantum Dots. - Friedel Sum Rule in One- And Quasi-One-Dimensional Wires. - Effects of Temperature on The Scattering Phases and Density of States in Quantum Wires.
Describing Software Developers Affectiveness through Markov chain Models

In this paper, we present an analysis of more than 500K comments from open-sourcerepositories of software systems.Our aim is to empirically determine how developers interact with each otherunder certain psychological conditions generated by politeness, sentiment andemotion expressed within developers' comments.Developers involved in an open-source projects do not usually know each other; they mainly communicate through mailing lists, chat rooms, and tools such as issue tracking systems.The way in which they communicate affects the development process and the productivity of the people involved in the project.We evaluated politeness, sentiment and emotions of comments posted by developers and studied the communication flow to understand how they interacted in the presence of impolite and negative comments (and vice versa). Our analysis shows that when in presence of impolite or negative comments, the probability of the next comment being impolite or negative is 14% and 25%, respectively; anger however,has a probability of 40% of being followed by a further anger comment.The result could help managers take control the development phases of a system, since social aspects can seriously affect a developer's productivity. In a distributed environment this may have a particular resonance.