Miracle-dz/UniFAR-FTUs huggingface dataset:
Adverse drug reactions of montelukast and pranlukast: Analysis of the Korea database.

BACKGROUND Leukotriene receptor antagonists are recommended to treat asthma and allergic rhinitis. Although they had been used for a long time, recent studies have reported neuropsychiatric adverse drug reactions are associated with montelukast. OBJECTIVE This study analyzed the adverse drug reactions of montelukast and pranlukast, which are the two most frequently prescribed leukotriene receptor antagonists, respectively in Korea. METHODS This study retrospectively reviewed ADRs of 5,426 montelukast and 1,146 pranlukast reported in the Korea Adverse Event Reporting System between January 2014 and December 2018. RESULTS When both drugs are classified by system organ class, the most adverse drug reactions were related to the gastro-intestinal system, followed by psychiatric events. The reported adverse drug reactions for both drugs were more common in women, and the ratio of adverse drug reactions to prescriptions was highest in the elderly. Women aged 19 to 64 years reported more than twice as many adverse drug reactions than men of the same age, and more than 5 times in insomnia. CONCLUSIONS When prescribing montelukast and pranlukast, attention would need to digestive and sleep disorders, especially women aged 19 to 64. After prescribing montelukast, physicians would need to pay more attention to agitation (5/396378 vs 0/82475), bad or vivid dreams (6/396378 vs 0/82475), anxiety (11/396378 vs 0/82475), depression (14/396378 vs 1/82475), tremor (53/396378 vs 7/82475), irritability (5/396378 vs 1/82475), insomnia (159/396378 vs 25/82475), and headache (68/396378 vs 10/82475), compared to when prescribing pranlukast. Further prospective research needs to elucidate the relationship between neuropsychiatric events and montelukast.
Physiotherapy Management of Migraine Pain: Facial Proprioceptive Neuromuscular Facilitation Technique Versus Connective Tissue Massage

Objective: Physical therapy modalities are often used by patients with migraine pain. The effectiveness of the methods in the treatment of migraine has not been clarified yet. This prospective study was planned to investigate whether facial proprioceptive neuromuscular facilitation is superior to connective tissue massage in the treatment of migraine pain. Methods: The study was conducted on 40 female patients with a neurologist-confirmed diagnosis of chronic migraine with non-aura, and who were aged between 18 and 65. They were randomly divided into 2 groups. Facial proprioceptive neuromuscular facilitation techniques were applied to the patients in the study group (Group 1), and connective tissue massage was applied to the patients in the control group (Group 2). The interventions were performed 3 times a week for approximately 20 minutes. Pain and pressure pain threshold scores were recorded on the first day of treatment before starting the session and were reassessed immediately after the end of the 18 treatment (6 weeks) sessions. Results: Pretreatment and posttreatment results were similar in both groups in terms of pain scores and pressure pain threshold values (P > 0.05). Both groups improved in pain-related outcomes (P < 0.05). Conclusions: Our results suggest that facial proprioceptive neuromuscular facilitation was no more effective than connective tissue massage for treating migraine for the sample size used in the present study. Both methods can be used in the treatment of migraine pain.
Host-directed antileishmanial interventions: Harvesting unripe fruits to reach fruition

Abstract Leishmaniasis is an exemplary paradigm of immune evasion, fraught with the perils of limited clinical assistance, escalating costs of treatment and made worse with the lack of suitable vaccine. While drugs remain central to large-scale disease control, the growing emergence of parasite resistance necessitates the need for combination therapy involving host-directed immunological agents. Also, since prolonged disease progression is associated with strong immune suppression of the host, augmentation of host immunity via restoration of the immunoregulatory circuit involving antigen-presenting cells and T-cells, activation of macrophage function and/or CD4+ T helper 1 cell differentiation may serve as an ideal approach to resolve severe cases of leishmaniasis. As such, therapies that embody a synergistic approach that involve direct killing of the parasite in addition to elevating host immunity are likely to pave the way for widespread elimination of leishmaniasis in the future. With this review, we aim to recapitulate the various immunotherapeutic agents found to hold promise in antileishmanial treatment both in vitro and in vivo. These include parasite-specific antigens, dendritic cell-targeted therapy, recombinant inhibitors of various components intrinsic to immune cell signaling and agonists or antagonists to immune cells and cytokines. We also summarize their abilities to direct therapeutic skewing of the host cell-immune response and review their potential to combat the disease either alone, or as adjunct modalities. Graphical abstract
FibROAD: a manually curated resource for multi-omics level evidence integration of fibrosis research

Abstract Organ fibrosis represents a vital health threat that substantially contributes to yearly mortality rates. While a considerable amount of research has been conducted on fibrosis, these reports have only focused on specific organs as affected within distinct disorders. Accordingly, results from such studies have been unable to provide a comprehensive understanding of the pathological processes involved. Here, we describe the development of FibROAD, an open-access database that integrates evidence from fibrosis-associated disorders as obtained from both the literature and multi-omics data. This resource will greatly assist both researchers and clinicians in the comprehension and treatment of this condition. FibROAD currently involves an assembly of 232 strong evidence-based fibrosis-related genes (FRGs) as garnered from 909 PubMed publications and contains lists of multi-omics data from > 4000 samples including RNA-seq, single-cell RNA-seq, miRNA-seq, ChIP-seq, ATAC-seq MeDIP-seq and MBD-seq as obtained from 17 different organs in 5 species. Results from integrative analyses as obtained using FibROAD have demonstrated that FRGs can be indicators for a wide range of organ fibrosis and reveal potential pro-fibrotic candidate genes for fibrosis research. In conclusion, FibROAD serves as a convenient platform where researchers can acquire integrated evidence and a more comprehensive understanding of fibrosis-related disorders. Database URL https://www.fibroad. org
Respirable Dust and Silica

The clinical significance of this paper is the statistically increased mortality and morbidity on respiratory diseases in outpatients of Swedish foundry workers, particularly COPD, at certain exposure levels. The results can be used as risk assessment for individuals to prevent the development of respiratory diseases and as basis for new occupational exposure limits. Objective The mortality and morbidity pattern for respiratory diseases was determined in a cohort of 1752 Swedish foundry workers, particularly for respirable silica dust exposure. Methods The morbidity follow-up in the Swedish National Non-primary Outpatient Register covered 2001 to 2017 (NPR; specialist not in care patients), the mortality from the National Causes of Death Register covered 2001 to 2017. Cumulative exposures to silica and dust were determined. Results The morbidity in COPD showed significantly increased risk for all exposure groups, as did silicosis in the high exposure group, these cases corresponded to silica exposure levels below 0.05 mg/m3. The mortality of all causes and respiratory diseases was significantly increased by cumulative silica exposure in the high exposure group. Conclusions Significantly increased morbidity for respiratory diseases and COPD was determined at silica exposure levels below the current Swedish OEL.
Study of the Security in Network Management Based on Mobile Agents

Security of mobile-agent based network management must be considered due to the widespread adoption of mobile agents in network management, which involves the protections of mobile agents, management station and managed devices. The integrated security model proposed in our paper incorporates the effective security countermeasures of these entities into a trusted execution environment and two security protection layers. Sandbox based on Java virtual machine and Jaua card independent on the network devices also with the cryptography technology in this model together protect the network management process.
Colonic mucosal eosinophilia and immunohistochemical expression of COX-2 and NF-kB in patients with irritable bowel syndrome

Background There is growing evidence that eosinophilic infiltration can release mediators which are harmful to the intestinal epithelium in patients with irritable bowel syndrome (IBS). Although cyclooxygenase 2 (COX-2) and nuclear factor-kappa beta (NF-kB) expression had been previously reported to increase in many inflammatory conditions, there is a paucity in data investigating their expressions in IBS. Our aim was to evaluate colonic mucosal eosinophilia and immunohistochemical expression of COX-2 and NF-kB in patients with irritable bowel syndrome. Methods A total of 80 patients who met the inclusion criteria of IBS based on Rome IV symptoms questionnaire were subjected to abdominal ultrasound, laboratory investigations, serum immunoglobulin E (IgE) level assessment and colonoscopic examination. Immunohistochemistry was performed to detect COX-2 and NF-kB expression in colonic biopsies obtained from IBS patients. Results Histopathological examination showed that 60 colonic biopsy specimens (75%) showed few mixed inflammatory cells ≤3 cells/ HPF, 12 biopsy specimens (15%) showed eosinophilic infiltration ≥25 eosinophils/HPF and 8 biopsy specimens (10%) showed severe lymphocytic infiltration and aggregation. Colonic eosinophilic infiltrate was significantly higher among patients presented with IBS-D subtype. Serum IgE was significantly higher among patients with colonic eosinophilic infiltrate than the others. In IBS-D patients, colonic mucosa showed positive expression of COX-2 and NF-kB in 52.1% and 81.25% of cases, respectively. Conclusion Patients with IBS -particularly IBS-D subtype- should undergo colonoscopy and biopsy to exclude underlying inflammatory pathology. Moreover, patients with positive COX-2 and NF-kB need further evaluation and follow-up.
Spectroscopic and Computational Characterization of 2-Aza-1,3-butadiene, a Molecule of Astrochemical Significance

Being N-substituted unsaturated species, azabutadienes are molecules of potential relevance in astrochemistry, ranging from the interstellar medium to Titan’s atmosphere. 2-Azabutadiene and butadiene share a similar conjugated π system, thus allowing investigation of the effects of heteroatom substitution. More interestingly, 2-azabutadiene can be used to proxy the abundance of interstellar butadiene. To enable future astronomical searches, the rotational spectrum of 2-azabutadiene has been investigated up to 330 GHz. The experimental work has been supported and guided by accurate computational characterization of the molecular structure, energetics, and spectroscopic properties of the two possible forms, trans and gauche. The trans species, more stable by about 7 kJ/mol than gauche-2-azabutadiene, has been experimentally observed, and its rotational and centrifugal distortion constants have been obtained with remarkable accuracy, while theoretical estimates of the spectroscopic parameters are reported for gauche-2-azabutadiene.
Assessment of Androgen Receptor Splice Variant-7 as a Biomarker of Clinical Response in Castration-Sensitive Prostate Cancer

Background: Therapies targeting the androgen receptor (AR) have improved the outcome for patients with castration-sensitive prostate cancer (CSPC). Expression of the constitutively active AR splice variant-7 (AR-V7) has shown clinical utility as a predictive biomarker of AR- targeted therapy resistance in castration-resistant prostate cancer (CRPC), but its importance as predictive biomarker in CSPC remains understudied. Methods: We explored multiple approaches to quantify AR-V7 mRNA and protein in prostate cancer cell lines and patient-derived xenograft (PDX) models, in both publicly available and independent institutional clinical cohorts, to identify reliable approaches for detecting AR-V7 mRNA and protein, and its association with clinical outcome. Results: In publicly available benign prostate, CSPC and CRPC cohorts, AR-V7 mRNA was much less abundant when detected using reads across splice boundaries than when considering isoform-specific exonic reads. The RM7 AR-V7 antibody had increased sensitivity and specificity for AR-V7 protein detection by immunohistochemistry (IHC) in CRPC cohorts and identified AR-V7 protein reactivity very rarely in CSPC cohorts, when compared to the EPR15656 AR-V7 antibody. Using multiple CRPC PDX models, we demonstrated that AR-V7 expression was exquisitely sensitive to hormonal manipulation. In CSPC cohorts, AR-V7 protein quantification by either assay did not associate with time to development of castration-resistance or overall survival, and intense neoadjuvant androgen-deprivation therapy did not lead to significant detectable AR-V7 mRNA or staining following treatment, and neither pre- nor post-treatment AR-V7 levels associated with the volume of residual disease after therapy. Conclusion: This study demonstrates that further analytical validation and clinical qualification is required before AR-V7 can be considered for clinical use in CSPC as a predictive biomarker.
Current epidemiological situation of COVID-19 in the Republic of Belarus: characteristics of the epidemic process, sanitary and anti-epidemic measures

Abstract: This is an analysis of the features of the COVID-19 pandemic the population of the Republic of Belarus from February 2020 to January 2021, the characteristics of sanitary and anti-epidemic measures carried out in the country, assessment of study the safety (tolerance) of the vaccines used the epidemiological efficacy of the vaccination. A retrospective analysis of COVID-19 cases in the Republic of Belarus from the beginning of registration (February 28, 2020) to January, 3, 2022 was performed. Vaccine safety (tolerance) and efficacy were assessed in an observational study. Safety (tolerance) was assessed by presence/absence of adverse reactions: general (fever, malaise, headache, muscle pain, runny nose, nausea, vomiting, sore throat, etc) and local ones (redness, swelling, soreness at the injection place). The COVID-19 pandemic in the Republic of Belarus is characterized by successive development stages: from no cases in early 2020 to detected cases where most individuals had no history of contact with COVID-19 patients; periods of rising and falling incidence Vaccines against COVID-19 (Gam-COVID-Vac (Russia), inactivated vaccine against SARS-CoV-2 (Vero Cell) Sinopharm / BIBP (China) demonstrated a high safety profile in mass vaccination of the population of the Republic of Belarus.
Arterial Oxygen and Carbon Dioxide Tension and Acute Brain Injury in Extracorporeal Cardiopulmonary Resuscitation Patients: Analysis of the Extracorporeal Life Support Organization Registry

Objective: Acute brain injury remains common after extracorporeal cardiopulmonary resuscitation. Using a large international multicenter cohort, we investigated the impact of peri-cannulation arterial oxygen (PaO2) and carbon dioxide (PaCO2) on ABI occurrence. Design: Retrospective cohort study. Setting: Data in the Extracorporeal Life Support Organization Registry from 2009 to 2020. Patients: Adult patients ([≥]18 years old) who underwent extracorporeal cardiopulmonary resuscitation. Interventions: None. Measurements and Main Results: Of 3,125 patients with extracorporeal cardiopulmonary resuscitation (median age=58, 69% male), 488 (16%) experienced at least one form of acute brain injury, which included ischemic stroke, intracranial hemorrhage, seizures, and brain death. 217 (7%) experienced ischemic stroke and 88 (3%) experienced intracranial hemorrhage. The registry collects two blood gas data pre- (6 hours before) and on- (24 hours after) extracorporeal membrane oxygenation (ECMO) cannulation. Blood gas parameters were classified as: hypoxia (<60mmHg), normoxia (60-119mmHg), and mild (120-199mmHg), moderate (200-299mmHg), and severe hyperoxia ([≥]300mmHg); hypocarbia (<35mmHg), normocarbia (35-44mmHg), mild (45-54mmHg) and severe hypercarbia ([≥]55mmHg). In multivariable logistic regression analysis, pre-ECMO hypoxia (aOR=1.46, 95%CI: 1.03-2.08, p=0.04) and on-ECMO severe hyperoxia (aOR=1.55, 95%CI: 1.02-2.36, p=0.04) were associated with composite ABI. Also, on-ECMO severe hyperoxia was associated with intracranial hemorrhage (aOR=1.88, 95%CI: 1.02-3.47, p=0.04) and in-hospital mortality (aOR=3.51, 95%CI: 1.98-6.22, p<0.001). Pre- and on-ECMO PaCO2 levels were not significantly associated with composite ABI or mortality, though mild hypercarbia pre- and on-ECMO were protective of ischemic stroke and intracranial hemorrhage, respectively. Conclusions: Early severe hyperoxia ([≥]300mmHg) on ECMO was a significant risk factor for acute brain injury and mortality for patients undergoing extracorporeal cardiopulmonary resuscitation. Careful consideration should be given in early oxygen delivery in ECPR patients who are at risk of reperfusion injury.
Isolation and Genetic Characterization of Emerging H3N2 Canine Influenza Virus in Guangdong Province, Southern China, 2018–2021

H3N2 canine influenza virus (CIV) emerged in dogs in China or Korea around 2005 and was first reported in 2008. In 2015, H3N2 CIV was detected in the United States and caused a huge outbreak. To date, H3N2 CIV is continuously circulating in dog populations in China, Korea, and the United States. For continuous monitoring of H3N2 CIV in China, we collected 180 dog nasal swab samples and 196 cat nasal swabs from veterinary hospitals in Guangdong Province between 2018 and 2021. Six emerging H3N2 CIV strains were isolated. Following full genome sequencing and phylogenetic analyses, we found that A/canine/Guangdong/1-3/2018 and A/canine/Guangdong/1-3/2021 diverged from the reported sequences of the Chinese H3N2 CIV strains. Moreover, we found that these H3N2 CIV strains belong to the group that contains US and northern China CIV strains in 2017 and 2019 and dominate in the dog population until 2021.
Lightweight Bimodal Rail Surface Defect Detection Method: Parallel-YOLOv4-Tiny

∗ Rail defect has been harmful to the safety of railway operation for a long time. At present, there is an urgent need for a fast and high-precision rail surface defect detection method which can be applied to comprehensive inspection vehicles. In this paper, we pro-pose a lightweight Bimodal Rail Surface Defect Detection Method, called Parallel-YOLOv4-Tiny, for bimodal rail surface defect images. We design a parallel feature processing strategy for bimodal image feature extraction in Parallel-YOLOv4-Tiny. A series of experiments show that Parallel-YOLOv4-Tiny with CIOU loss function can achieve a mAP of 92.07 at 88 FPS on a single GPU. Parallel-YOLOv4-Tiny has a much better performance than other original YOLOv4-Tiny methods, which shows the validity and advancement of Parallel-YOLOv4-Tiny. Parallel-YOLOv4-Tiny can meet the practical application requirements of high-speed railways and improve the efficiency of daily railway patrol inspection.
Semi-Automated X-ray Transmission Image Annotation Using Data-efficient Convolutional Neural Networks and Cooperative Machine Learning

X-ray Transmission (XRT) based sorting machines used in the mineral recovery process employ machine learning techniques on the acquired XRT images to extract relevant visual information required to classify crushed mineral ore particles at high accuracy. The performance of these techniques is often compromised by insufficient annotated data required during training, resulting in a high false-negative error rate (particle of interest classified as waste material). Obtaining annotated data or annotating a large volume of visual data remains a challenging issue due to manual, time-consuming and highly labour-intensive work. Over the past years, efforts have been made to develop various semi-automatic image annotation techniques ranging from traditional machine learning (which uses handcrafted features) to deep learning techniques to address these deficiencies. Deep learning (DL) techniques, particularly Convolutional Neural Networks (CNNs), has proven to have a powerful learning ability in the context of high-dimensional data processing and automatic feature extraction. However, DL techniques are very greedy when it comes to the amount of training data required instead of traditional machine learning techniques. This paper describes an approach to generating an annotated XRT image dataset using a data-efficient CNN technique with a human in the loop, cooperative machine learning (CML).
Information Security and Knowledge Sharing: A Blockchain Perspective

This study aimed to investigate the various paradigms on which the blockchain technology functions to ensure the highest standards of data transparency and security. Blockchain have been recently gaining much criticism on the grounds of scalability, security, and sustainability at large. However, even though the scholarly interests for the technology practice has increased substantially in the recent years, a comprehensive analysis regarding data security offered through blockchain applications has been severely lacking a systematic elaboration. According to the obtained results from this study, it was apparent that blockchain technology not only holds the potentials to ensure data security better than the traditional ways of information storing and sharing, but also maintains its flexibility to allow further reformations to suffice data security demands in the future.
ForeSI: Success-Aware Visual Navigation Agent: Supplementary Material

1. Sub-Goal Identification In Figure 1 1 we separately show how our agent identifies a sub-goal in hindsight after an episode is completed. The agent takes the actions as described in the main paper until reaching the final state, e.g. either the ”STOP” action is selected or the maximum number of permitted actions are exhausted. Then, it selects the state with the maximum attention weight αjas the sub-goal and adds the tuple of (s0,gτ , ŝτ ) to the replay buffer. The replay buffer is, then, used to train the sub-goal generation module, as described in the main paper. Furthermore, note that in our sub-goal selection mechanism we add position embedding to each state representation si to maintain the order of the observed states in the sub-goal selection, inspired by [3].
LONGITUDINAL CONTROL OF DUAL-MODE VEHICLES: AN OVERVIEW

This overview which includes a representative listing of reported efforts in this field, encompasses a discussion of control concepts and approaches applicable to other classes of individual automated ground transport. Relevant information on the modeling of vehicle dynamics is also included. Three categories of control are discussed: steady-state, constant-speed control with respect to some type of reference; organization between traffic stream interaction points; merging, existing, or station operations or all of these. Two general approaches toward achieving control in the categories have been advocated: synchronous control; and the asynchronous approach, the following are essential: either explicity account for the nonlinearities that are invariably present or in some manner "cancel" their effects; evaluate the effects of large paramter variations in the selected model; be aware of, and properly account for acceleration capabilities of a vehicle and how these change with speed. The need is indicated for the development of a suitably economical and reliable reference system for providing vehicle controllers with high-quality rate control information.