Miracle-dz/UniFAR-FTUs huggingface dataset:
Anti-thrombotic Therapy With Cangrelor and Bivalirudin in Venoarterial Extracorporeal Membrane Oxygenation Patients Undergoing Percutaneous Coronary Intervention: A Single-Center Experience

VA-ECMO is commonly used for patients in cardiogenic shock (CS) or refractory cardiac arrest (CA) undergoing PCI for ACS. In this setting at high risk of both thrombotic and hemorrhagic complications, optimal anti-thrombotic therapy remains ill-defined. We hypothesized that an anti-thrombotic therapy comprising a parenteral anticoagulant (bivalirudin) and a parenteral anti-platelet agent (cangrelor) may prove safe and effective in this scenario. From November 2019 to December 2021, 14 patients received at least one dose of cangrelor (starting dose: 0.125 μg/kg/min) plus bivalirudin, without background aspirin, in the context of PCI and VA-ECMO for ACS-related CS/CA, and were included in this study. Efficacy endpoint was occurrence of thrombotic events and safety endpoint was major bleeding occurrence. Median age was 58 years. The majority (64%) presented with refractory CA. A thrombotic event occurred in 14%, while major bleeding occurred in 21% patients. One patient experienced arterial thrombosis after VA-ECMO arterial cannula removal, another experienced ischemic cerebellar stroke without functional sequelae. Bleeding events were: 29% BARC 3a, 14% BARC 3b, and 7% BARC 5b. Overall in-hospital mortality was 50%. Cangrelor was continued for 5 (4–10) days; temporary discontinuation was necessary in 36%, either for VA-ECMO cannula removal or for bleeding events. A low dose of cangrelor, associated with standard-intensity anticoagulation with bivalirudin was a feasible anti-thrombotic strategy in patients undergoing PCI during VA-ECMO support for ACS-related CS/CA. Bleeding events rates outweighed thrombotic events rates in this critically-ill population, although the observed rates were lowest among available studies.
Imaging of an Infalling Disklike Envelope around L1551 IRS 5

Aperture synthesis observations of H13CO+ (J = 1-0) emission from L1551 IRS 5 were made using the Nobeyama Millimeter Array. It is found that the emission has a disklike structure with a size of 5600 × 2800 AU at P.A. = 160°. If we assume a geometrically thin disk, its radius and inclination angle are estimated to be 2800 AU and 60° [= cos–1 (2800/5600)], and the disk major axis is almost perpendicular to the molecular outflow. It is noted that there exists radial motion, i.e., velocity gradient along the disk minor axis in the inner region (r < 1000 AU). The motion can be interpreted as infalling motion because the blueshifted emission is located on the far side of the disk and the redshifted emission on the near side by considering the geometrical relation between the H13CO+ feature and the bipolar outflow. The infalling velocity corrected for the inclination is estimated to be 0.6 km s–1 at r = 800 AU and is smaller than the free-fall velocity (∼ 1. 5 km s−1 at r = 800 AU ) with a stellar mass of 1 M☉. The H2 mass of the disk and the mass infall rate are estimated to be 0.27 M☉ and ~1.1 × 10-5 M☉ yr–1, respectively. In addition to the infalling motion, the molecular emission also has a velocity structure along the major axis, suggesting rotating motion. The rotational velocity corrected for the inclination is estimated to be 0.23 km s–1 at r = 900 AU, which is smaller than Keplerian rotational velocity, suggesting that the envelope is not rotationally supported. The H13CO+ disklike structure would be a disklike infalling envelope around L1551 IRS 5.
Generalizing univariate signed rank statistics for testing and estimating a multivariate location parameter

We generalize signed rank statistics to dimensions higher than one. This results in a class of orthogonally invariant and distribution free tests that can be used for testing spherical symmetry/location parameter. The corresponding estimator is orthogonally equivariant. Both the test and estimator can be chosen with asymptotic efficiency 1. The breakdown point of the estimator depends only on the scores, not on the dimension of the data. For elliptical distributions, weobtain an affine invariant test with the same asymptotic properties, if the signed rank statisticis applied to standardized data. We also present a method for computing the estimator numerically, and consider a real data example and some simulations. Finally, an application to detection of time-varying signals in spherically symmetric noise is given.
Confidence sequences with composite likelihoods

In dominated parametric statistical models, confidence sequences provide conservatively valid frequentist inference directly from a likelihood ratio. They ensure a specific mode of replicability when inference is performed on accumulating data: inferential conclusions that are compatible with a guaranteed probability when the sample is enlarged, in the form of overlapping confidence regions. Here we consider both Robbins' mixture confidence sequences and running maximum likelihood confidence sequences recently considered by Wasserman, Ramdas, and Balakrishnan. We compare through simulation the replicability properties of the two kinds of confidence sequences, evaluating, along a prospected enlargement of the sample, the frequency of incompatible estimation intervals and the frequency of failure of simultaneous coverage of the true parameter value. Moreover, we propose a shortcut to extend the application of mixture confidence sequences to pseudo‐likelihoods, in particular to composite likelihood. The main assumption required is that normal asymptotic theory offers a good approximation to the density of the maximizer of the pseudo‐likelihood. When inference is about a scalar parameter of interest, the computation of the proposed sequence of confidence intervals is straightforward. The method is illustrated by an example with replicability properties evaluated through simulation.
Bacterial Burden in the Air of Indoor Riding Arenas

Airway diseases in horses are often multifactorial and have a strong environmental background because diseased horses react to inhaled agents. In this study, the air quality of closed riding arenas was analyzed monthly in four riding arenas over the course of one year with special emphasis on bacteriology. A standardized riding program with one horse was used to measure exposures to airborne bacteria. Air samples were taken from the heights of the riders’ and the horses’ breathing zone (2.5 m and 1.5 m, respectively) at four sampling points before and after the riding program. The bacterial loads in all four arenas significantly increased after the riding program. However, the results showed no differences between the breathing zones of the riders (2.5 m height) and those of the horses (1.5 m height). Gram-positive bacteria and especially Staphylococcus spp. occurred as the predominant aerobic mesophilic bacteria; 80% of the identified Staphylococci were Staphylococcus xylosus. The cultured samples from the ground of the arenas indicated that the ground was probably the main source of airborne Staphylococcus spp. during riding. The impact of an additional bacterial burden in riding halls on the health of riders and horses remains unknown; however, the air quality of riding arenas should be of special interest in future studies in terms of the high air consumption of horses during training periods.
Nonlinear Piezo-Actuator Control by Learning Self-Tuning Regulator

This paper presents a laerning self-tuning (LSTR) regulator which improves the tracking performance of itself while performing repetitive tasks. The controller is a self-tuning regulator based on learning parameter estimation. Experimentally, the controller was used to control the movement of a nonlinear piezoelectric was used to control the movement of a nonlinear piezoelectric actuator which is a part of the tool positioning system for a diamond turning lathe
The Integral Boosting Effect of Selenium on the Secondary Metabolism of Higher Plants

Selenium is a micronutrient with a wide range of functions in animals, including humans, and in microorganisms such as microalgae. However, its role in plant metabolism remains ambiguous. Recent studies of Se supplementation showed that not only does it increase the content of the element itself, but also affects the accumulation of secondary metabolites in plants. The purpose of this review is to analyze and summarize the available data on the place of selenium in the secondary metabolism of plants and its effect on the accumulation of some plant metabolites (S- and N-containing secondary metabolites, terpenes, and phenolic compounds). In addition, possible molecular mechanisms and metabolic pathways underlying these effects are discussed. It should be noted that available data on the effect of Se on the accumulation of secondary metabolites are inconsistent and contradictory. According to some studies, selenium has a positive effect on the accumulation of certain metabolites, while other similar studies show a negative effect or no effect at all. The following aspects were identified as possible ways of regulating plant secondary metabolism by Se-supplementation: changes occurring in primary S/N metabolism, hormonal regulation, redox metabolism, as well as at the transcriptomic level of secondary metabolite biosynthesis. In all likelihood, the confusion in the results can be explained by other, more complex regulatory mechanisms in which selenium is involved and which affect the production of metabolites. Further study on the involvement of various forms of selenium in metabolic and signaling pathways is crucial for a deeper understanding of its role in growth, development, and health of plants, as well as the regulatory mechanisms behind them.
Direct electrical observation of spin Hall effect in Bi film

The strong spin-orbit coupling of Bi makes it an ideal candidate for investigation of the spin Hall effect. Here, we provide the report of a direct electronic observation of the spin Hall effect in Bi film. When a current flows in the Bi film, electrons with opposite spin orientations separately accumulate on the top and bottom surfaces due to the spin Hall effect. The accumulated spins are electrically detected by a ferromagnetic film attached to the bottom surface of the Bi film. At a temperature of 3.0K, the observed voltage difference induced by the magnetization reversal is 1. 2μV. By using the previously reported calculation based on the semiclassical Boltzmann equation, we find that the spin Hall conductivity multiplied by the spin injection efficiency is 1.98×102(Ωm)−1.
Spectral tuning of liquid microdroplets standing on a superhydrophobic surface using electrowetting

Using electrowetting, we demonstrate reversible spectral tuning of the whispering gallery modes of glycerol/water microdroplets standing on a superhydrophobic surface by up to 4.7nm at 400V. Our results can inspire electrically tunable optical switches and filters based on microdroplets on a superhydrophobic surface. The sensitivity of the observed spectral drift to the contact angle can also be used to measure the contact angles of microdroplets on a superhydrophobic surface.
Load-displacement relations for nanoindentation of viscoelastic materials

A model based on the Burgers viscoelastic concept has been developed to describe the nanoindentation behaviors of polymeric materials. An analytical solution of displacement at the indenter tip has been derived based on the analog of the governing equation of elasticity in the time coordinate system to the governing equation of the viscoelastic model in Laplace transform coordinate system. The solution consists of the elastic, viscous, and plastic displacements during loading and unloading. Nanoindentation experiments have been conducted for poly(methyl methacrylate), polycarbonate, hydroxyethyl methacrylate copolymer, amorphous syndiotactic polystyrene, and fast-cure acrylic polymers to provide data for validating the model. The results show excellent agreement between experimental load-displacement data and model prediction for both the loading and unloading before the contact area decreases for all five polymers. The viscosity decreases but the hardness increases with increasing loading rate. Young’s m.
Quantifying Gram-Negative Resistance to Empiric Treatment After Repeat ExpoSure To AntimicRobial Therapy (RESTART)

Abstract Background Antibiotic exposure is a primary predictor of subsequent antibiotic resistance; however, development of cross-resistance between antibiotic classes is also observed. The impact of changing to a different antibiotic from that of previous exposure is not established. Methods This was a retrospective, single-center cohort study of hospitalized adult patients previously exposed to an antipseudomonal β-lactam (APBL) for at least 48 hours in the 90 days prior to the index infection with a gram-negative bloodstream or respiratory infection. Susceptibility rates to empiric therapy were compared between patients receiving the same (repeat group) versus a different antibiotic from prior exposure (change group). Results A total of 197 patients were included (n = 94 [repeat group] and n = 103 [change group]). Pathogen susceptibility to empiric therapy was higher in the repeat group compared to the change group (76.6% vs 60.2%; P = .014). After multivariable logistic regression, repeat APBL was associated with an increased likelihood of pathogen susceptibility (adjusted odds ratio, 2.513; P = .012). In contrast, there was no difference in susceptibility rates between the repeat group and the subgroup of change patients who received an empiric APBL (76.6% vs 78.5%; P = .900). Longer APBL exposure duration (P = .012) and chronic kidney disease (P = .002) were associated with higher nonsusceptibility to the exposure APBL. In-hospital mortality was not significantly different between the repeat and change groups (18.1% vs 23.3%; P = .368). Conclusions The common practice of changing to a different APBL from that of recent exposure may not be warranted.
Derivations Mapping into the Radical III

We obtain commutativity-free characterizations of those derivations d on a unital complex Banach algebra A that map A into its radical: dA ⊆ rad(A) if and only if there exists a constant M ≥ 0 such that r(dx) ≤ Mr(x) for all x ∈ A, which in turn is equivalent to sup{r(z−1dz) | z ∈ A invertible} < ∈ (where r(·) is denoting the spectral radius). The second characterization answers positively a question raised by J. Zemanek.
A Deeper Insight into the Tick Salivary Protein Families under the Light of Alphafold2 and Dali: Introducing the TickSialoFam 2.0 Database

Hard ticks feed for several days or weeks on their hosts and their saliva contains thousands of polypeptides belonging to dozens of families, as identified by salivary transcriptomes. Comparison of the coding sequences to protein databases helps to identify putative secreted proteins and their potential functions, directing and focusing future studies, usually done with recombinant proteins that are tested in different bioassays. However, many families of putative secreted peptides have a unique character, not providing significant matches to known sequences. The availability of the Alphafold2 program, which provides in silico predictions of the 3D polypeptide structure, coupled with the Dali program which uses the atomic coordinates of a structural model to search the Protein Data Bank (PDB) allows another layer of investigation to annotate and ascribe a functional role to proteins having so far being characterized as “unique”. In this study, we analyzed the classification of tick salivary proteins under the light of the Alphafold2/Dali programs, detecting novel protein families and gaining new insights relating the structure and function of tick salivary proteins.
CONTROLE DE QUALIDADE EM ANÁLISE SENSORIAL: UMA REVISÃO

A análise sensorial é cada vez mais utilizada na concepção e desenvolvimento de produtos industriais, garantindo a sua competitividade no mercado a que pertencem. Neste artigo, explica-se em que se consiste a análise sensorial e sua utilidade na inovação e desenvolvimento de produtos cárneos industrializados. Aborda-se sobre os principais métodos sensoriais (técnicas tradicionais e modernas), Diferentes tipos de análises sensoriais (analíticas e afetivas), desde métodos convencionais (Análise Descritiva Quantitativa) até novas técnicas sensoriais rápidas (Check All That Apply ou Marque tudo que se aplique, Napping, Flash Profile, Temporal Dominance of Sensations, etc.) têm sido utilizados como técnicas cruciais no desenvolvimento de novos produtos para avaliar a qualidade e a viabilidade comercializável dos novos produtos. Foi utilizada a revisão bibliográfica em bases acadêmicas conceituadas, além de periódicos publicados nos últimos 5 anos. Como resultado, além da apresentação das técnicas supracitadas, discute-se a importância da utilização da análise sensorial de produtos cárneos industrializados, para a indústria e consumidores de uma forma geral.
Moving Ship Optimal Association for Maritime Surveillance: Fusing AIS and Sentinel-2 Data

Nowadays, a variety of different sources can be combined together to measure and monitor maritime human activities. Reliable data fusion techniques are essential to associate the targets from different systems for maritime surveillance. In particular, the fusion of data from Sentinel-2 satellites and the automatic identification system (AIS) has attracted wide attention due to their public availability and complementarity. However, most traditional methods for target association are not suitable for this particular case, due to the time lag phenomenon of Sentinel-2 data. In this study, we first construct two new datasets for the detection of moving ships and their wakes based on Sentinel-2 images. Combined with the detection results obtained by the you only look once (YOLOv5) model, the position and course information of the detected ships are first extracted. After carefully analyzing the time lag phenomenon of Sentinel-2 data, we develop a new domain adaptation-based method for target association based on the fusion of Sentinel-2 and AIS data, called moving ship optimal association (MSOA). Different from standard domain adaptation methods only for representation alignment, the proposed MSOA is able to align representation, time, and position simultaneously. A case study is provided in which the newly proposed method is tested over the Port of Long Beach, USA. Experimental results demonstrate that both moving ships and wakes are well detected. Specifically, our newly proposed MSOA exhibits more accurate and robust performance when compared to traditional methods, and the detected ships without corresponding AIS tracks can also be detected by our MSOA. Moreover, the real sensing time and time lag of Sentinel-2 data are deduced with high accuracy. Overall, it can be concluded that our MSOA provides a new perspective for accurate target association based on heterogeneous data fusion.
ON THE EXISTENCE AND NONEXISTENCE OF SOLUTIONS FOR SOME NONLINEAR WAVE EQUATIONS OF KIRCHHOFF TYPE

In this work, we consider the following nonlinear problem \begin{equation*} \begin{array}{c} \ds u_{tt}-M(\Vert \nabla u(t)\Vert ^{2}_2)\Delta u-\frac{\partial }{\partial t}% \ds \Delta u=f(u), \\ [1\eqnskip] \ds u=0\text{ \ in }\Gamma _{0}\times (0,T), \\ [0.8\eqnskip] \ds M(\Vert \nabla u(t)\Vert ^{2}_2)\frac{\partial u}{\partial \nu }+\ds\frac{\partial }{\partial t}(\frac{\partial u}{\partial \nu })=-u_{t}\text{ \ in }% \Gamma _{1}\times (0,T), \\ [1.5\eqnskip] u(x,0)=u_{0}(x),\text{ \ }u_{t}(x,0)=u_{1}(x),% \end{array}% \end{equation*}% in a bounded domain $\Omega . $ The existence, asymptotic behavior and nonexistence of solutions are discussed under some conditions.
PERFORMANCE ANALYSIS AND EVALUATION OF MASSIVE MIMO SYSTEM

This article examines the performance of massive MIMO uplink system over Rician fading channel. The performance is estimated regarding spectral efficiency versus number of base station antennas utilizing three plans of linear detection, maximum-ratio-combining (MRC), zero forcing receiver (ZF), and minimum mean-square error receiver (MMSE). The simulation results reveal that the spectral efficiency increments altogether with expanding the quantity of base station antennas. Additionally, the spectral efficiency with MMSE is superior to that with ZF, and the last is superior to that with MRC. Furthermore, the spectral efficiency diminishes with expanding the fading parameter.
Characterization of the optical components fabricated by femtosecond pulses in transparent materials

We report optical characterization of the different optical components fabricated in transparent materials by bulk refractive index modification or surface ablation by femtosecond pulses. The methods used for characterization of the components with refractive index modification fabricated in fused silica by high repetition rate femtosecond KGW:Yb laser were transmission and diffraction measurements at 532 and 632.8 nm wavelengths, and total integrated scattering (TIS) at 532 mn wavelength. The combined characterization methods were sufficient for modification process optimization and allowed creation of the Bragg gratings with diffraction efficiency in range from 55 to 90% and low scattering losses. The forward and backward TIS measurements of the radial polarization converter showed that forward scattering is more than five times as high as backward scattering. Solar cells with modified surface by femtosecond pulse ablation were investigated by TIS and Volt-Ampere measurements. The current increase is registered with growth of the scattering loses in the solar cells.
Equations of motion for the sources of asymptotically flat spaces

We present an exact calculation that leads to the equations of motion (which naturally contain gravitational radiation reaction terms) of a system subject to no external forces. The novelty of our approach lies in the fact that the system is to be considered as the source of an asymptotically flat space and that all the revelant physical quantities such as the velocity νμ, 4‐momentum pμ, angular momentum‐center of mass tensor Sμν (as well as higher moments) are then defined in terms of surface integrals taken at infinity. A subset of the Einstein equations (equivalent to Bondi's supplemantary conditions) then yields the time‐evolution equations for these variables.
Bogolubov-Hartree-Fock mean field theory for neutron stars and other systems with attractive interactions

A simplification of the Bogolubov–Hartree–Fock theory, which is a natural generalization of the traditional Hartree–Fock theory, is derived. This simplification allows to express the pairing interaction in terms of the one-particle density matrix for systems interacting by attractive pair potentials, such as the Newtonian gravitational potential.
BORON DOPING OF SILICON USING COALLOYING WITH ALUMINIUM

We present a new technique for boron (B) doping of silicon. In this letter we show that a B doping profile of more than 2 μm thickness with a maximum active doping concentration of 3×1019 cm−3 can be formed by a fast (<1 min) alloying process at a temperature of 850 °C. Thick‐film aluminum is used to obtain an alloying and epitaxial regrowth process in accordance with the Al–Si phase diagram. The atomic concentration profile of the B‐ and Al‐doped Si layer was determined by secondary ion mass spectrometry. The active doping concentration was measured with an automatic electrochemical capacitance/voltage profiler. By the addition of B to the Al paste, the epitaxially regrown layer is doped with B and Al to the solid solubility of these elements in Si at the particular regrowth temperature. The applicability of this fast low temperature B doping process in Si solar cell processing is discussed.