Miracle-dz/UniFAR-FTUs huggingface dataset:
Joint developmental trajectories of internalizing and externalizing problems from mid-childhood to late adolescence and childhood risk factors: Findings from a prospective pre-birth cohort.

There is limited evidence on heterogenous co-developmental trajectories of internalizing (INT) and externalizing (EXT) problems from childhood to adolescence and predictors of these joint trajectories. We utilized longitudinal data from Raine Study participants (n = 2393) to identify these joint trajectories from 5 to 17 years using parallel-process latent class growth analysis and analyze childhood individual and family risk factors predicting these joint trajectories using multinomial logistic regression. Five trajectory classes were identified: Low-problems (Low-INT/Low-EXT, 29%), Moderate Externalizing (Moderate-EXT/Low-INT, 26.5%), Primary Internalizing (Moderate High-INT/Low-EXT, 17.5%), Co-occurring (High-INT/High-EXT, 17%), High Co-occurring (Very High-EXT/High-INT, 10%). Children classified in Co-occurring and High Co-occurring trajectories (27% of the sample) exhibited clinically meaningful co-occurring problem behaviors and experienced more adverse childhood risk-factors than other three trajectories. Compared with Low-problems: parental marital problems, low family income, and absent father predicted Co-occurring and High Co-occurring trajectories; maternal mental health problems commonly predicted Primary Internalizing, Co-occurring, and High Co-occurring trajectories; male sex and parental tobacco-smoking uniquely predicted High Co-occurring membership; other substance smoking uniquely predicted Co-occurring membership; speech difficulty uniquely predicted Primary Internalizing membership; child's temper-tantrums predicted all four trajectories, with increased odds ratios for High Co-occurring (OR = 8.95) and Co-occurring (OR = 6.07). Finding two co-occurring trajectories emphasizes the importance of early childhood interventions addressing comorbidity.
CHANGE CHARACTERISTICS OF HEALTH-RELATED QUALITY OF LIFE AND ITS ASSOCIATION WITH POST-STROKE FATIGUE AT FOUR-YEAR FOLLOW-UP

Objective To explore trajectories that describe change in post-stroke health-related quality of life with fatigue as outcome. Design Observational and prospective study. Subjects Stroke survivors (N = 144) with predominantly mild or moderate strokes. Methods The multidimensional Stroke-Specific Quality of Life scale was used at 1 and 4 years, and the Fatigue Severity Scale at 4 years post-stroke. Latent class growth analyses were used as person-oriented analyses to identify meaningful trajectories. Socio-demographic and stroke-related covariables provided customary adjustment of the outcome, as well as prediction of class membership. Results The latent class growth analysis models were estimated for “physical health”, “visual-language”, and “cognitive-social-mental” components of the Stroke-Specific Quality of Life scale, which extracted trajectories describing a variation in stable, deteriorating and improving functional patterns. The stable, well-functioning trajectory was most frequent across all components. More pronounced fatigue was associated with trajectories describing worse functioning, which was more prominent among females compared with males. Living alone implied more fatigue in the “cognitive-social-mental” component. Within the “visual-language” components’ trajectories, younger and older participants reported more fatigue compared with middle-aged participants. Conclusion Most participants belonged to the stable, well-functioning trajectories, which showed a consistently lower level of fatigue compared with the other trajectories. LAY ABSTRACT The long-term consequences of stroke may be highly individual and multifaceted. The question of how such individual differences may unfold and change beyond the first year after stroke may be of substantial clinical interest regarding which subgroups show more favourable and unfavourable rehabilitation trajectories. The current study explored functional trajectories from 1 to 4 years post-stroke and their association with post-stroke fatigue. A total of 144 individuals with mainly mild or moderate strokes were included. Their functions were measured with the Stroke-Specific Quality of Life scale at 1 and 4 years post-stroke, and fatigue with the Fatigue Severity Scale 4 years post-stroke. The study found that the majority of subjects belonged to the trajectories described as stable, well-functioning from 1 to 4 years post-stroke. Participants who experienced less fatigue were those who had the highest and most stable function throughout the recovery course.
Direct mode repeater in a mobile radio system

(57) Abstract: The present invention relates to a mobile station communicating on the direct mode channel (MS1-MS 6) direct mode repeater to send traffic between (R1, R2), and to the use of repeaters. The repeater includes a mobile station (MS1-MS6) transceiver sends a wireless message while units communicating on direct mode channels (TRX), controls the operation of the relay (R2), a transceiver unit (TRX) and a control unit for directing the direct mode channel (C). To prevent the number of repeaters to communicate simultaneously in the same direct mode channel, transmission on the direct mode channel directly to the mode channel sending a radio message repeater (R1, R2), said repeater (R1, R2) of identifiers (13) including at desired intervals, the identifier, the relay (R1, R2) is instructed to send the traffic on the direct mode channel, and said repeater (R1, R2) monitors the direct mode channel when said repeater (R2) is going Kawaro cut to direct mode channel (203), and the identifier from another repeater during a predetermined monitoring period (R1) (13) There configured to switch to a direct mode channel only if no direct mode channel above.
Atlas-based segmentation technique incorporating inter-observer delineation uncertainty for whole breast

Accurate, efficient auto-segmentation methods are essential for the clinical efficacy of adaptive radiotherapy delivered with highly conformal techniques. Current atlas based auto-segmentation techniques are adequate in this respect, however fail to account for inter-observer variation. An atlas-based segmentation method that incorporates inter-observer variation is proposed. This method is validated for a whole breast radiotherapy cohort containing 28 CT datasets with CTVs delineated by eight observers. To optimise atlas accuracy, the cohort was divided into categories by mean body mass index and laterality, with atlas’ generated for each in a leave-one-out approach. Observer CTVs were merged and thresholded to generate an auto-segmentation model representing both inter-observer and inter-patient differences. For each category, the atlas was registered to the left-out dataset to enable propagation of the auto-segmentation from atlas space. Auto-segmentation time was recorded. The segmentation was compared to the gold-standard contour using the dice similarity coefficient (DSC) and mean absolute surface distance (MASD). Comparison with the smallest and largest CTV was also made. This atlas-based auto-segmentation method incorporating inter-observer variation was shown to be efficient (<4min) and accurate for whole breast radiotherapy, with good agreement (DSC>0.7, MASD <9.3mm) between the auto-segmented contours and CTV volumes.
Risk of unruptured aneurysms in subarachnoid hemorrhage patients with multiple intracranial aneurysms: a multicenter, longitudinal, comparative study from China

Background In aneurysmal subarachnoid hemorrhage patients with multiple intracranial aneurysms (aSAH-MIA patients), the risk of secondary unruptured intracranial aneurysms is inconsistent. This study aimed to explore the risk of unruptured aneurysms in Chinese aSAH-MIA patients. Methods The medical records and angiographic images of aSAH-MIA patients from eight cerebrovascular centers in China were retrospectively reviewed and analyzed. Patients with a single unruptured intracranial aneurysm (UIA) and no prior aSAH were used as controls. Propensity score matching (PSM) was employed to balance the differences in age, gender, aneurysm size, aneurysm site, and follow-up duration between the two groups. Results The study included 267 unruptured aneurysms from 204 aSAH-MIA patients and 769 single UIA. After PSM, 201 aneurysms were enrolled in the aSAH-MIA group and 201 aneurysms in the control group. The mean follow-up was 2.2 years. Thirty-four aneurysm instability events (28 growth and 6 rupture, 16.9%) occurred during follow-up in the aSAH-MIA group and 16 instability events (13 growth and 3 rupture, 8%) occurred in the control group. Risk factors for aneurysmal instability were aneurysm irregularity (OR 2.53; 95% CI 1.18 to 4.31), higher size ratio (OR 1.23; 95% CI 1.37 to 4.39), and middle cerebral artery location (OR 1.86; 95% CI 1.03 to 3.17). The risk of aneurysmal instability was substantially elevated in the aSAH-MIA group (HR 2.07; 95% CI 1.12 to 3.02). Conclusions Unruptured aneurysms in Chinese aSAH-MIA patients exhibited higher risks of growth and rupture than in patients with a single UIA. Middle cerebral artery location, higher size ratio and irregular shape were associated with higher risk of growth or rupture.
Less attention to emotional faces is associated with low empathy and prosociality in 12-to 20-month old infants.

The development of empathy and prosocial behavior begins in infancy and is likely supported by emotion processing skills. The current study explored whether early emerging deficits in emotion processing are associated with disruptions in the development of empathy and prosociality. We investigated this question in a large, diverse sample of 147, 11- to 20-month-old infants (42% female; 61% Black; 67% low socioeconomic status). Infants completed two observational tasks assessing prosocial helping and one task assessing empathy and prosocial comforting behavior. Infants also completed an eye-tracking task assessing engagement and disengagement with negative emotional faces. Infants who attended less to angry, sad, and fearful faces (i.e., by being slower to look at and/or quicker to look away from negative compared to neutral faces) engaged in fewer helping behaviors, and effect sizes were larger when examining infants' attention toward the eye regions of faces. Additionally, infants who were quicker to look away from the eye regions of angry faces, but not the whole face, displayed less empathy and comforting behaviors. Results suggest that as early as 12 months of age, infants' decreased attention toward negative emotional faces, particularly the eye regions, is associated with less empathy and prosociality during a developmental period in which these abilities are rapidly maturing.
Genetic regulation of enteric nervous system development in zebrafish

The enteric nervous system (ENS) is a complex series of interconnected neurons and glia that reside within and along the entire length of the gastrointestinal tract. ENS functions are vital to gut homeostasis and digestion, including local control of peristalsis, water balance, and intestinal cell barrier function. How the ENS develops during embryological development is a topic of great concern, as defects in ENS development can result in various diseases, the most common being Hirschsprung disease, in which variable regions of the infant gut lack ENS, with the distal colon most affected. Deciphering how the ENS forms from its progenitor cells, enteric neural crest cells, is an active area of research across various animal models. The vertebrate animal model, zebrafish, has been increasingly leveraged to understand early ENS formation, and over the past 20 years has contributed to our knowledge of the genetic regulation that underlies enteric development. In this review, I summarize our knowledge regarding the genetic regulation of zebrafish enteric neuronal development, and based on the most current literature, present a gene regulatory network inferred to underlie its construction. I also provide perspectives on areas for future zebrafish ENS research.
Pleistocene to Recent tectonics in the Rhenish Massif (Germany)

Abstract Uplift of the Rhenish Massif can be demonstrated by means of the stream-made river terrace system that accompanies the Rhine river and its tributaries along their way through or within this part of the Variscan fold and thrust belt. The height difference between a former valley floor, especially that of the Younger ‘Hauptterrasse’ (Main Terrace), and the recent one allows to quantify the uplift by the amount of downcutting erosion. The uplift velocity increased just after the BRUNHES / MATUYAMA boundary, i.e. about 0.8 Ma B.R Since that time, a domal uplift of more than 250 m is documented in the eastern Hunsriick and in the south-eastern Eifel. The area of this maximum height anomaly is situated just between the East-and West-Eifel Quaternary volcanic districts. Thus, causal connections are supposed. The domai uplift is affected by normal faulting partly inherited since Tertiary rifting.
Composite dietary antioxidant index associated with delayed biological aging: a population-based study

Objective: The objective of this study was to explore the potential correlation between the composite dietary antioxidant index (CDAI) and biological aging, addressing the insufficient epidemiological evidence in this area. Methods: Participants meeting eligibility criteria were selected from the National Health and Nutrition Examination Surveys (NHANES) conducted between 2001 and 2018. CDAI was determined based on dietary antioxidants obtained from 24-hour dietary recalls. Biological age was determined using PhenoAge algorithms incorporating various clinical features. Weighted multiple models were employed to investigate and assess the association between CDAI and biological age. Results: Analysis of the CDAI quartile revealed disparities in terms of age, gender, ethnicity, educational level, marital status, poverty, dietary calories intakes, smoking, drinking status, BMI, physical activity, and PhenoAge. After adjusting for potential confounding factors, a significant inverse relationship was found between CDAI and Phenotypic Age, with each standard deviation increase in CDAI score correlating with a 0.18-year decrease in Phenotypic Age. These negative correlations between CDAI and PhenoAge advancement were observed regardless of age, gender, physical activity status, smoking status, and body mass index. Conclusions: Our findings demonstrate a positive relationship between higher CDAI scores and delayed biological aging. These results have significant implications for public health initiatives aimed at promoting healthy aging through dietary interventions.
Impacts of Electrofi shing Removals on the Introduced Flathead Catfi sh Population in the Satilla River, Georgia

Recent modeling indicates that increased exploitation on nonnative fl athead catfi sh Pylodictis olivaris may be an avenue for native species recovery. Flathead catfi sh were illegally introduced into the Satilla River, Georgia, and negative impacts have occurred on na- tive fi shes. In an effort to aid in the restoration of native fi sh on the Satilla River, the Georgia Department of Natural Resources initiated an intensive electrofi shing removal effort. In this study, we evaluated the changes in fl athead catfi sh total mortality, condition, and size structure from those efforts. From 2007 to 2009, 13,472 fl athead catfi sh totaling 19,337 kg were re- moved along a 129-km stretch of the Satilla River. The population size structure changed sub- stantially from containing many large individuals (59% � 510 mm total length (TL)) in 2007 to mainly small fi sh (79% � 356 mm TL) by 2009. Total biomass per effort declined from 57.05 kg/h in 2007 to 19.96 kg/h in 2009. Mean individual weight of fi sh removed decreased from 2.64 kg in 2007 to 1.32 kg in 2008 to 0.61 kg in 2009. Population age structure was also truncated, but there was evidence for higher recruitment and earlier maturation, which would require that intensive harvest be maintained to prevent the population from rebuilding within 2-5 years. Catch-curves revealed increasing total annual mortality rates of 37, 48 and 52%, for 2007-2009, respectively. Considering the life history of the fl athead catfi sh, being a long-lived species that presumably cannot withstand excessive rates of exploitation (i.e., greater than 25% exploitation), our results indicated that an electrofi shing removal program is a reason- able management option for areas where this apex predator has been introduced, but continual removal may be required to maintain low biomass.
Brucella targets the host ubiquitin-specific protease, Usp8, through the effector protein, TcpB, for facilitating infection of macrophages

ABSTRACT Brucella species are Gram-negative intracellular bacterial pathogens that cause the worldwide zoonotic disease brucellosis. Brucella can infect many mammals, including humans and domestic and wild animals. Brucella manipulates various host cellular processes to invade and multiply in professional and non-professional phagocytic cells. However, the host targets and their modulation by Brucella to facilitate the infection process remain obscure. Here, we report that the host ubiquitin-specific protease, USP8, negatively regulates the invasion of Brucella into macrophages through the plasma membrane receptor, CXCR4. Upon silencing or chemical inhibition of USP8, the membrane localization of the CXCR4 receptor was enriched, which augmented the invasion of Brucella into macrophages. Activation of USP8 through chemical inhibition of 14-3-3 protein affected the invasion of Brucella into macrophages. Brucella suppressed the expression of Usp8 at its early stage of infection in the infected macrophages. Furthermore, we found that only live Brucella could negatively regulate the expression of Usp8, suggesting the role of secreted effector protein of Brucella in modulating the gene expression. Subsequent studies revealed that the Brucella effector protein, TIR-domain containing protein from Brucella, TcpB, plays a significant role in downregulating the expression of Usp8 by targeting the cyclic-AMP response element-binding protein pathway. Treatment of mice with USP8 inhibitor resulted in enhanced survival of B. melitensis, whereas mice treated with CXCR4 or 14-3-3 antagonists showed a diminished bacterial load. Our experimental data demonstrate a novel role of Usp8 in the host defense against microbial intrusion. The present study provides insights into the microbial subversion of host defenses, and this information may ultimately help to develop novel therapeutic interventions for infectious diseases.
Benign and malignant prostate neoplasms show different spatial organization of collagen

Aim To compare the indicators of the spatial organization of collagen and its regulating factors between benign and malignant prostate neoplasms. Methods The study involved tumor tissue samples from 40 patients with stage II-III prostate cancer (PCa) and 20 patients with benign prostatic hyperplasia (BPH). The localization of collagen was determined with a Masson trichrome stain. To establish quantitative indicators of the spatial organization of collagen, morphometric studies were carried out with the CurveAlign and ImageJ programs. Results PCa tissue had two times lower collagen density (P < 0.0001) and 1.3 times lower levels of collagen alignment (P = 0.018) compared with BPH tissue. In PCa tissue, collagen fibers were shorter (by 24.2%; P < 0.001) and thicker (by 15.5%; P < 0.001). PCa tissue samples showed significantly higher levels of metalloproteinase (MMP)-2 (by 2.4 times; P = 0.001), MMP-8 (by 2.3 times; P = 0.007), and MMP-13 (by 1.9 times; P = 0.004). Conclusions Collagen matrix spatial organization features, as well as its regulatory factors, could be potential biomarkers of malignant prostate neoplasms.
Differences in molecular sensitization profiles between a Spanish and Latin American mite allergic patients.

BACKGROUND AND OBJECTIVE To analyze the sensitization pattern to Dermatophagoides pteronyssinus and to associate the diagnostic findings and clinical severity in 218 allergic patients from two different continents. METHODS Mite allergic patients were recruited by the Allergology departments from Latin America (n=88: Colombia, Costa Rica and Guatemala) and Spain (N=130). All patients had allergic rhinitis with or without asthma and positive skin prick test results to D. pteronyssinus. Specific IgE levels to D. pteronyssinus, D. farinae, Der p 1, Der p 2, and Der p 23 were quantified by ImmunoCAP system (ThermoFisher Scientific). Allergenic profile was also determined by western blot. Comparative Statistical analysis was performed by GraphPad software. RESULTS Patients recognized most frequently Der p 2 (79%) followed by Der p 1 (73%), and Der p 23 (69%) allergens. The percentage of asthmatic patients increases with the number of sensitizations however none statistically significant differences were found. Interestingly, asthmatic patients presented the highest median levels of total IgE and specific IgE levels of D. pteronyssinus and molecular allergens, mainly Der p 2. Analysing the two different populations, Spanish patients were predominantly sensitized to Der p 2 (88.46%) and Der p 1 (83.84%), whereas Latin American population were more sensitized to Der p 23. CONCLUSION Our data support the relevance of Der p 2 in mite allergy as the major allergen, with the high number of patients sensitized to it and its importance in the development of asthma. Sensitization to Der p 23 was more important in Latin America.