Miracle-dz/UniFAR-FTUs huggingface dataset:
Gastroesophageal reflux prophylaxis decreases the incidence of pharyngocutaneous fistula after total laryngectomy

Pharyngocutaneous fistula is a serious complication after laryngectomy. Gastric fluid is known to cause severe laryngopharyngeal injury and poor mucosal healing. This study was designed to evaluate the effects of a gastroesophageal reflux prophylaxis regimen on the incidence of fistula after laryngectomy. Twenty‐one consecutive patients were entered in the study. Patients with positive resection margins were excluded from the overall analysis. All patients had a Connell's two‐layer closure of the pharynx with absorbable suture, suction drainage of the neck, postoperative tube feeding, and prophylactic antibiotics. All patients were started on an antireflux regimen postoperatively composed of continuous tube feeds, intravenous ranitidine, and intravenous metoclopramide hydrochloride. Patients were followed postoperatively with Gastrografin swallows and clinically for 8 weeks. The control group consisted of retrospectively studied patients managed identically except for the antireflux prophylaxis. The two groups were well matched for factors reported to influence the rate of pharyngocutaneous fistula formation. The control group had six fistulae (26%) and an average of 16.5 days of hospital stay. The study group had no fistulae and an average of 11.5 days of hospital stay (P = .02). This study suggests that gastroesophageal reflux may predispose to fistula formation after laryngectomy and that mechanical and pharmacological prophylaxsis decreases postoperative morbidity and length of hospital stay.
Female Methamphetamine Users: Social Characteristics and Sexual Risk Behavior

ABSTRACT The primary objective of this research was to expand our knowledge regarding the personal and social characteristics of female methamphetamine (meth) users, their motivations for using meth, patterns of meth use, medical and social problems associated with meth use, and the relationship between meth use and sexual risk behaviors. The sample consisted of 98 HIV-negative, heterosexually-identified, meth-using females residing in San Diego, California. Female meth users were characterized by personal and social disadvantage, high rates of psychiatric symptomatology, and high levels of sexual risk behavior, including multiple partners, risky partner types (e.g., anonymous sex partners), and high rates of unprotected vaginal and oral sex. Meth use was also associated with the subjective positive experience of sex. These finding suggest that behavioral interventions should be tailored to the social characteristics of female meth users, and program content should reflect the intertwining of women's sexual experience and meth use.
Outcomes of a new residential scheme for adults with intellectual disabilities in Taiwan: a 2-year follow-up.

BACKGROUND The Taiwanese government launched a new programme in November 2004 to support adults with intellectual disabilities living in smaller facilities. This paper aims to evaluate the service outcomes of this new residential scheme over 2 years including those residents who moved from an institution and those who moved from their family. METHODS A one-group repeated-measures analysis was conducted for five interviews after the adults with intellectual disabilities entered the new environment. Forty-nine adults were initially studied (T1) and 29 adults remained in the homes until the end of the study (T5). RESULTS This study found significant improvements over the 2 years in the residents' quality of life and family contact. The results also highlight a decrease in maladaptive behaviour among the residents moving from institution and an increase in choice making and family contact among the residents moving from family. No significant changes in adaptive behaviour and community inclusion were found. CONCLUSION Results revealed that further policy changes and financial support including service quality assurance are required in order to improve service outcomes for adults living in the new residential scheme.
Gender and Regional Differences in Creativity: A Comparative Study on Playfulness and Humor in Postgraduate Students Between Mainland China and Taiwan

This article aims to study both similarities and differences in female students’ creativity between Mainland China and Taiwan. As two main aspects influencing creativity, playfulness and humor are especially focused on in this comparative study. Empirical data were collected from 831 students in Mainland China and 703 students in Taiwan. Based on data analysis, we find common characteristics, gender differences, and regional differences in the creativity of female postgraduate students. The female students in both regions are less confident in their abilities in scientific research and innovative behavior than males. The female students in Mainland China are less confident in playfulness, humor, and creative life experience than their counterparts. The female students in Taiwan are more masculine than their counterparts in Mainland China.
School accessibility and academic achievement in a rural area of Taiwan

This study empirically analyzes the influence of school accessibility on student academic achievement in a rural area of Taiwan. The sample population comprised elementary and junior high-school students in Pinlin, a small village outside Taipei City, the capital of Taiwan. Data were obtained through a questionnaire survey and analyzed via linear regression and ordered logit regression for continuous grade point average and discrete letter grade, respectively. Compared with previous research, this study presents the following new findings: (1) similar to elementary-school children, travel obstacles also negatively affected learning achievement of junior high-school adolescents; (2) travel obstacles affected academic achievement more significantly for adolescents than children; and (3) travel obstacles affected letter grades more significantly than grade point averages in children. The empirical evidence indicates that travel obstacles explain the academic achievements of children and adolescents with moderate or weak significance.
Comparing outcomes of different treatment regimens for severe haemophilia

Summary. Published retrospective reports from France, the Netherlands and Sweden were analysed for data relating to the long‐term outcomes (primarily the development of arthropathy) of three regimens for the management of severe haemophilia: on‐demand treatment, intermediate‐dose prophylaxis and high‐dose prophylaxis. The mean annual consumption of factor concentrate was also compared. These data indicate that both prophylaxis regimens resulted in significantly improved long‐term outcomes, as assessed by pain, clinical and radiological assessment scores. At the same time, the most recently reported annual factor consumption levels of these young adult patients are comparable in the on‐demand and intermediate‐dose prophylaxis cohorts, suggesting that the improvement in long‐term clinical outcomes and reduced risk of arthropathy may lead to reduced factor consumption in adult patients who received early prophylactic therapy.
Batman, Pandaman and the Blind Man: A Case Study in Social Change Memes and Internet Censorship in China

While the internet has been examined as a utilitarian space for social movements, it also acts as a cultural space for personal and community expression about important social issues. While examining the particularities of the memetic form – often catchy humor, simple imagery, and remixing – the author examines meme culture as a vehicle for political and social critique in the context of China’s stringent web censorship and propaganda. She looks at social change memes that have arisen around internet censorship and in support of the blind lawyer activist Chen Guangcheng. First, she considers these memes as visual and creative practices that sidestep the mechanics of internet censorship in China. She then argues for the role of internet memes in challenging hegemonic media environments, and maintains that these actions should be considered important political acts in and of themselves.
Women's clitoris, vagina, and cervix mapped on the sensory cortex: fMRI evidence.

INTRODUCTION The projection of vagina, uterine cervix, and nipple to the sensory cortex in humans has not been reported. AIMS The aim of this study was to map the sensory cortical fields of the clitoris, vagina, cervix, and nipple, toward an elucidation of the neural systems underlying sexual response. METHODS Using functional magnetic resonance imaging (fMRI), we mapped sensory cortical responses to clitoral, vaginal, cervical, and nipple self-stimulation. For points of reference on the homunculus, we also mapped responses to the thumb and great toe (hallux) stimulation. MAIN OUTCOME MEASURES The main outcome measures used for this study were the fMRI of brain regions activated by the various sensory stimuli. RESULTS Clitoral, vaginal, and cervical self-stimulation activated differentiable sensory cortical regions, all clustered in the medial cortex (medial paracentral lobule). Nipple self-stimulation activated the genital sensory cortex (as well as the thoracic) region of the homuncular map. CONCLUSION The genital sensory cortex, identified in the classical Penfield homunculus based on electrical stimulation of the brain only in men, was confirmed for the first time in the literature by the present study in women applying clitoral, vaginal, and cervical self-stimulation, and observing their regional brain responses using fMRI. Vaginal, clitoral, and cervical regions of activation were differentiable, consistent with innervation by different afferent nerves and different behavioral correlates. Activation of the genital sensory cortex by nipple self-stimulation was unexpected, but suggests a neurological basis for women's reports of its erotogenic quality.
Increased risk of depression in patients with rheumatoid arthritis: a seven-year population-based cohort study

OBJECTIVE: Rheumatoid arthritis (RA) is a costly and crippling autoimmune disease that can lead to the development of depression, contributing to suboptimal clinical outcomes. However, no longitudinal studies have identified an association between rheumatoid arthritis and subsequent depression. This study aimed to investigate the incidence and risk factors of depression among RA patients in Taiwan. METHODS: Using Taiwan's National Health Insurance Research Database, we identified 3,698 newly diagnosed RA patients aged 18 years or older, together with 7,396 subjects without RA matched by sex, age and index date, between 2000 and 2004. The incidence of depression and the risk factors among RA cases were evaluated using Cox proportional-hazard regression. RESULTS: The incidence of depression was 1.74-fold greater in the RA cohort than in the non-RA cohort (11.80 versus 6.89 per 1,000 person-years; p<0.01). Multivariate analysis showed that RA subjects who were female, were older, or had comorbidities such as stroke, chronic kidney disease, or cancer had a significantly greater risk of depression compared with those without these conditions. CONCLUSION: This population-based cohort study showed a strong relationship between RA and a subsequent risk of depression. The findings could be beneficial to healthcare providers for identifying individuals with a higher predisposition for depression, thereby possibly facilitating the provision of an appropriate rehabilitation intervention after RA onset to support the patient's adaptation.
Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study.

BACKGROUND Human papillomavirus (HPV), the causal agent of cervical cancer, appears to be involved in the etiology of cancer of the oral cavity and oropharynx. To investigate these associations, we conducted a multicenter case-control study of cancer of the oral cavity and oropharynx in nine countries. METHODS We recruited 1670 case patients (1415 with cancer of the oral cavity and 255 with cancer of the oropharynx) and 1732 control subjects and obtained an interview, oral exfoliated cells, and blood from all participants and fresh biopsy specimens from case patients. HPV DNA was detected by polymerase chain reaction (PCR). Antibodies against HPV16 L1, E6, and E7 proteins in plasma were detected with enzyme-linked immunosorbent assays. Multivariable models were used for case-control and case-case comparisons. RESULTS HPV DNA was detected in biopsy specimens of 3.9% (95% confidence interval [CI] = 2.5% to 5.3%) of 766 cancers of the oral cavity with valid PCR results and 18.3% (95% CI = 12.0% to 24.7%) of 142 cancers of the oropharynx (oropharynx and tonsil combined) with valid PCR results. HPV DNA in cancer biopsy specimens was detected less frequently among tobacco smokers and paan chewers and more frequently among subjects who reported more than one sexual partner or who practiced oral sex. HPV16 DNA was found in 94.7% of HPV DNA-positive case patients. HPV DNA in exfoliated cells was not associated with cancer risk or with HPV DNA detection in biopsy specimens. Antibodies against HPV16 L1 were associated with risk for cancers of the oral cavity (odds ratio [OR] = 1.5, 95% CI = 1.1 to 2.1) and the oropharynx (OR = 3.5, 95% CI = 2.1 to 5.9). Antibodies against HPV16 E6 or E7 were also associated with risk for cancers of the oral cavity (OR = 2.9, 95% CI = 1.7 to 4.8) and the oropharynx (OR = 9.2, 95% CI = 4.8 to 17.7). CONCLUSIONS HPV appears to play an etiologic role in many cancers of the oropharynx and possibly a small subgroup of cancers of the oral cavity. The most common HPV type in genital cancers (HPV16) was also the most common in these tumors. The mechanism of transmission of HPV to the oral cavity warrants further investigation.
Predicting Intentions to Engage in Casual Sex

The objective of this study was to test the usefulness of the Triandis model of interpersonal behavior for explaining the formation of intentions to engage in casual sex (i.e. the likelihood that the respondent would, when they were out to have a good time, have sex with someone he or she had just met). Data were collected from 305 university students (243 female, 62 male). The Triandis model explained 44 percent of the variance in casual sex intentions. The strongest influences on intentions to engage in casual sex were personal standards, situational expectations and previous casual sex experience. Also, peer endorsement of casual sex was significant for men. The results indicate that the Triandis multivariate model is very effective in explaining sexual intentions. Hopefully, this study will encourage other researchers to investigate the under-explored topic of casual sex.
Ocular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies

Purpose To study the ocular manifestations of rheumatoid arthritis and to correlate the role of anti-cyclic citrullinated peptide antibody (anti-CCP antibody) with the ocular manifestations. Methods Three-hundred and ninety-two eyes of the 196 rheumatoid arthritis patients who attended the ophthalmology outpatient department underwent a detailed ocular examination using slit lamp biomicroscopy and ophthalmoscopy. The tear function of all the patients was assessed using Schirmer’s test, tear film break-up time and ocular surface staining. The anti-CCP antibody titers for all the rheumatoid arthritis patients were estimated using enzyme-linked immunosorbent assay tests. Results Seventy-seven patients (135 eyes, 39%) out of the 196 patients studied had ocular manifestations typical of rheumatoid arthritis. Dry eye was the most common manifestation (28%, 54 patients). Of the patients, 78% was females (60 patients). The mean duration of rheumatoid arthritis in patients with ocular manifestations was 5.4±2.7 years and without ocular manifestations was 2.1±1.6years. Three percent of the patients had episcleritis (six patients). Scleritis was present in 2% of the patients (four patients). Peripheral ulcerative keratitis and sclerosing keratitis was present in 1% of the population each (two patients each). Eighty-five percent (66 patients) had bilateral manifestations 15% (eleven patients) had unilateral manifestations. There was a strong association between the presence of anti-CCP antibodies and ocular manifestations of rheumatoid arthritis which was shown by the statistically significant P-value of <0.0001. Conclusion Ocular manifestations are a significant part of the extra-articular manifestation of rheumatoid arthritis. Dry eye was the most common ocular manifestation. There was a statistically significant association between the presence of anti-CCP antibodies specific to rheumatoid arthritis and the ocular manifestations.
A global portrait of counselling psychologists’ characteristics, perspectives, and professional behaviors

Counseling psychologists in eight countries (Australia, Canada, New Zealand, South Africa, South Korea, Taiwan, the United Kingdom, and the United States) responded to survey questions that focused on their demographics as well as their professional identities, roles, settings, and activities. As well, they were asked about satisfaction with the specialty and the extent to which they endorsed 10 core counseling psychology values. This article reports those results, focusing both on areas in which there were between-country similarities as well as on those for which there were differences. These data provide a snapshot of counseling psychology globally and establish a foundation for the other articles in this special issue of the journal.
Sulfur hexafluoride (SF 6) emissions in East Asia determined by inverse modeling

Sulfur hexafluoride (SF 6) has a global warming potential of around 22 800 over a 100-year time horizon and is one of the greenhouse gases regulated under the Kyoto Protocol. Around the year 2000 there was a reversal in the global SF6 emission trend, from a decreasing to an increas- ing trend, which was likely caused by increasing emissions in countries that are not obligated to report their annual emis- sions to the United Nations Framework Convention on Cli- mate Change. In this study, SF6 emissions during the period 2006-2012 for all East Asian countries - including Mongo- lia, China, Taiwan, North Korea, South Korea and Japan - were determined by using inverse modeling and in situ at- mospheric measurements. We found that the most impor- tant sources of uncertainty associated with these inversions are related to the choice of a priori emissions and their as- sumed uncertainty, the station network as well as the me- teorological input data. Much lower uncertainties are due to seasonal variability in the emissions, inversion geome- try and resolution, and the measurement calibration scale. Based on the results of these sensitivity tests, we estimate that the total SF6 emission in East Asia increased rapidly from 2404± 325 Mg yr 1 in 2006 to 3787± 512 Mg yr 1 in 2009 and stabilized thereafter. China contributed 60-72 % to the total East Asian emission for the different years, followed by South Korea (8-16 %), Japan (5-16 %) and Taiwan (4- 7 %), while the contributions from North Korea and Mongo- lia together were less than 3 % of the total. The per capita SF6 emissions are highest in South Korea and Taiwan, while the per capita emissions for China, North Korea and Japan are close to global average. During the period 2006-2012, emissions from China and from South Korea increased, while emissions from Taiwan and Japan decreased overall.
Porn, Peers, and Performing Oral Sex: The Mediating Role of Peer Norms on Pornography’s Influence Regarding Oral Sex

ABSTRACT The goal of this study was to offer insights into how pornography use might be linked to young adults’ sexual experiences via the mediating role of peer norms (i.e., their perceptions of what same-sex peers do sexually). We focused on oral sex behavior, as it is common in pornography and among young people. Young adults (N = 349; ages 19–30; 54% female) were recruited through a crowdsourcing website. Participants completed an anonymous online survey about the frequency that they observed various sexual behaviors in online pornography, the frequency that they engaged in these behaviors, and their perceptions of the frequency that their peers engaged in these behaviors. Frequency of viewing cunnilingus (men) or fellatio (women) in pornography predicted how often they engaged in oral sex, and this association was mediated by their perceptions of how frequently their peers engaged in oral sex. Peer norms did not mediate how frequently they received oral sex. Findings are discussed in terms of implications for understanding how pornography may relate to young people’s social norms surrounding oral sex and their performance of sexual behaviors, as well as for understanding generally how media consumption relates to adoption of media behaviors through suggesting a social norm.
Anti-CarP antibodies in two large cohorts of patients with rheumatoid arthritis and their relationship to genetic risk factors, cigarette smoking and other autoantibodies

Introduction In rheumatoid arthritis (RA), several genetic risk factors and smoking are strongly associated with the presence of anticitrullinated protein antibodies (ACPA), while much less is known about risk factors for ACPA-negative RA. Antibodies against carbamylated proteins (anti-CarP) have been described in both ACPA-positive and ACPA-negative RA patients. In this study, we have analysed the relationships among anti-CarP antibodies, ACPA, genetic risk factors (HLA-DRB1 alleles and PTPN22) and smoking in RA. Methods Presence of antibodies to carbamylated fetal calf serum (CarP-FCS) and fibrinogen (CarP-Fib) was determined by inhouse ELISAs among RA cases in the Leiden Early Arthritis Clinic (n=846) and in the Swedish Epidemiological Investigation of Rheumatoid Arthritis (n=1985) cohorts. ORs for associations with different HLA-DRB1 alleles, PTPN22 genotypes and smoking were calculated separately for each cohort as well as in meta-analysis in RA subsets defined by the presence/absence of anti-CarP and anticyclic citrullinated peptide (anti-CCP) antibodies. Results In both cohorts, anti-CarP antibody positivity was mainly detected in the anti-CCP-positive population (49%–73%), but also in the anti-CCP-negative population (8%–14%). No associations between anti-CarP antibodies and HLA-DRB1 shared epitope alleles could be identified, while there were data to support an association between anti-CarP-FCS and HLA-DRB1*03. Further analyses did not reveal any specific associations of anti-CarP antibodies with other HLA-DRB1 alleles, PTPN22 genotypes or smoking. Conclusions Anti-CarP antibodies were present in both ACPA-positive and ACPA-negative RA. There were no significant associations among anti-CarP antibodies and HLA-DRB1 alleles, PTPN22 or smoking. These data suggest that different biological mechanisms may underlie anti-CarP versus anti-CCP antibody formation.