Miracle-dz/UniFAR-FTUs huggingface dataset:
Aspirin-Based Organoiron Dendrimers as Promising Anti-Inflammatory, Anticancer, and Antimicrobial Drugs

Designing nanocarriers with actions directed at a specific organ or tissue is a very promising strategy since it can significantly reduce the toxicity of a bioactive drug. In this study, an organometallic dendrimer was used to synthesize a biocompatible drug delivery system by attaching aspirin to the periphery of the dendrimer. Our goal is to enhance the bioavailability and anticancer activity of aspirin and reduce its toxicity through successive generations of organoiron dendrimers. The biological activity of aspirin-based dendrimer complexes was evaluated. The result of antimicrobial activity of the synthesized dendrimers also demonstrated an increase in their antimicrobial activity with increased generation of the dendrimers for most types of microorganisms. This study reveals for the first time that organoiron dendrimers linked with aspirin exhibit an excellent Gram-negative activity comparable to the reference drug Gentamicin. All synthesized dendrimers were tested for their anticancer activity against breast cancer cell lines (MCF-7), hepatocellular cell lines (Hep-G2), and a non-cancer cell line, Human Embryonic Kidney (HEK293), using the MTT cell viability assay and compared against a standard anticancer drug, Doxorubicin. Compounds G3-D9-Asp and G4-D12-Asp exhibited noticeable activity against both cell lines, both of which were more effective than aspirin itself. In addition, the in vivo anti-inflammatory activity and histopathology of swollen paws showed that the designed aspirin-based dendrimers displayed significant anti-inflammatory activity; however, G2-D6-Asp showed the best anti-inflammatory activity, which was more potent than the reference drug aspirin during the same period. Moreover, the coupling of aspirin to the periphery of organoiron dendrimers showed a significant reduction in the toxicity of aspirin on the stomach.
Predicting the In Vivo Performance of Cardiovascular Biomaterials: Current Approaches In Vitro Evaluation of Blood-Biomaterial Interactions

The therapeutic efficacy of a cardiovascular device after implantation is highly dependent on the host-initiated complement and coagulation cascade. Both can eventually trigger thrombosis and inflammation. Therefore, understanding these initial responses of the body is of great importance for newly developed biomaterials. Subtle modulation of the associated biological processes could optimize clinical outcomes. However, our failure to produce truly blood compatible materials may reflect our inability to properly understand the mechanisms of thrombosis and inflammation associated with biomaterials. In vitro models mimicking these processes provide valuable insights into the mechanisms of biomaterial-induced complement activation and coagulation. Here, we review (i) the influence of biomaterials on complement and coagulation cascades, (ii) the significance of complement-coagulation interactions for the clinical success of cardiovascular implants, (iii) the modulation of complement activation by surface modifications, and (iv) in vitro testing strategies.
Multiphoton Microscopy for Identifying Collagen Signatures Associated with Biochemical Recurrence in Prostate Cancer Patients

Prostate cancer is a heterogeneous disease that remains dormant for long periods or acts aggressively with poor clinical outcomes. Identifying aggressive prostate tumor behavior using current glandular-focused histopathological criteria is challenging. Recent evidence has implicated the stroma in modulating prostate tumor behavior and in predicting post-surgical outcomes. However, the emergence of stromal signatures has been limited, due in part to the lack of adoption of imaging modalities for stromal-specific profiling. Herein, label-free multiphoton microscopy (MPM), with its ability to image tissue with stromal-specific contrast, is used to identify prostate stromal features associated with aggressive tumor behavior and clinical outcome. MPM was performed on unstained prostatectomy specimens from 59 patients and on biopsy specimens from 17 patients with known post-surgery recurrence status. MPM-identified collagen content, organization, and morphological tumor signatures were extracted for each patient and screened for association with recurrent disease. Compared to tumors from patients whose disease did not recur, tumors from patients with recurrent disease exhibited higher MPM-identified collagen amount and collagen fiber intensity signal and width. Our study shows an association between MPM-identified stromal collagen features of prostate tumors and post-surgical disease recurrence, suggesting their potential for prostate cancer risk assessment.
Craving for Generality and Small-N Studies

This chapter addresses the question: “How can findings from case studies and ethnographies be generalized? ” It advances an epistemological defence of small-N studies in the context of organization and management theory by drawing on Wittgenstein, and argues that the distinctive theoretical contribution of small-N studies stems from seeing particular cases as opportunities for further refining our conceptualization of general processes. Theorizing is an analogical process: small-N studies researchers notice analogies with processes described in other studies and, in an effort to account for the specificity of the particular case under study, draw new distinctions and thus further refine what is currently known. It is not so much analytical generalization that small-N studies aid as heuristic generalization (or analytical refinement). By doing so, the craving for generality is the craving for a clearer view. They aid generic understanding without annihilating the epistemic significance of the particular.
Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia

Stent implantation impairs local endothelial function and may be associated with subsequent adverse cardiovascular events. Telmisartan, an angiotensin II receptor blocker that has unique peroxisome proliferator-activated-receptor-gamma-mediated effects on cardiovascular disease, has been shown to enhance endothelial function and limit neointimal hyperplasia. This study utilized hybrid biodegradable/stent nanofibers to facilitate sustained and local delivery of telmisartan to injured arterial vessels. Telmisartan and poly(d,l)-lactide-co-glycolide (PLGA) (75:25) were dissolved in hexafluoroisopropyl alcohol and electrospun into biodegradable nanofibrous tubes which were coated onto metal stents. By releasing 20% of the loaded telmisartan in 30 days, these hybrid biodegradable/stent telmisartan-loaded nanofibers increased the migration of endothelial progenitor cells in vitro, promoted endothelialization, and reduced intimal hyperplasia. As such, this work provides insights into the use of PLGA nanofibers for treating patients with an increased risk of stent restenosis.
Twenty-eight new species of Trigonopterus Fauvel (Coleoptera, Curculionidae) from Central Sulawesi

Abstract Here we present 28 new species of Trigonopterus from Central Sulawesi, mostly from Mt Dako and Mt Pompangeo: Trigonopterusacutussp. nov., T.ancorasp. nov., T.arcanussp. nov., T.coronasp. nov., T.dakoensissp. nov., T.daunsp. nov., T.ewoksp. nov., T.gundalasp. nov., T.hopplasp. nov., T.kakimerahsp. nov., T.katopasensissp. nov., T.matakensissp. nov., T.moduaisp. nov., T.monssp. nov., T.paramoduaisp. nov.T. pomberimbensissp. nov., T.pompangeensissp. nov., T.puspoisp. nov., T.rosichonisp. nov., T.rubidussp. nov., T.sarinoisp. nov., T.sutrisnoisp. nov., T.tanahsp. nov., T.tejokusumoisp. nov., T.toboliensissp. nov., T.tolitoliensissp. nov., T.tounaensissp. nov., T.unyilsp. nov. This fills important areas of distribution and brings the number of Trigonopterus species recorded from Sulawesi to 132.
Marketing digital transforma la gestión de Pymes en Colombia

Las empresas, organizaciones y negocios, deben estar innovando en su gestión para tener mayor visibilidad, alcanzar más fácilmente sus objetivos y conseguir las anheladas utilidades; para ello, hacen uso de estrategias y como en los últimos años surgió el marketing digital -como estrategia conjunta e integradora, que se propone generar prospectos o leads y forjar transacciones- se indagó acerca de los resultados de su aplicación en las pymes en Colombia, conociéndose que gracias a las innumerables herramientas que surgen diariamente, se han fortalecido estas pequeñas y medianas empresas. Al analizar la gestión de estas entidades, que están presentes en todos los sectores económicos, se descubrió que cada vez es más frecuente el empleo del marketing digital en su cotidianeidad, bien sea para propiciar la comunicación con los diferentes públicos con los que interactúan, como oportunidad comercial o para reforzar su imagen y posicionamiento; así, por todas las ventajas que se mostraran que posee, es un apoyo ideal para estar a la vanguardia en el mercadeo. Este artículo presenta, cómo el marketing digital -definido como un canal de comunicación que emplea medios digitales- se ha convertido en un complemento de la mezcla de mercadotecnia; así mismo, despliega las estrategias y herramientas que más utiliza en el ámbito de las pymes para contribuir a que se logren los objetivos de estas unidades empresariales. Por último, se expone las ventajas de su empleo en las organizaciones que lo practican, por lo que se perfila como la primera opción para la mayoría de las pequeñas y medianas empresas en Colombia.
Implementation of Apriori Algorithm for Determining Purchase Patterns in One Transaction

The organization data owned is one of the assets of the organization. With the daily operational activities, the longer the data will increase. By using techniques that can do data processing, these data can be obtained important information that can be used for future developments. Association rules are one of these techniques which aims to find patterns in the form of products that are often purchased together or tend to appear together in a transaction from transaction data which is generally very large by using the concept association rules themselves derived from Market Basket Analysis terminology, namely search for relationships from several products in a purchase transaction. In designing this application will build applications that classify the data items based on the tendency to appear together in a transaction using the Apriori Algorithm. The Apriori algorithm is the first algorithm and is often used to find association rules in data mining applications with association rule techniques.
J

Determination of reproductive season is based on the presence of pregnant females and male testis position and size in several micro-mammals in wild life. However, the endocrine function of the testicles is unknown. Our goal was to evaluate, on a monthly basis during the two reproductive seasons of the year, the relationship between circulating testosterone level and testis recrudescence on adult males of free living Black-eared deermouse Peromyscus melanotis from a mid-latitude temperate forest. Our evidence shows a pattern of raise and fall, though decoupled by a month, between both processes, which sheds light on their physiological relationship in this species, as well as about its plasticity to respond to environmental conditions. They also warn us against customarily inferences about reproductive activity based only in position and size of testes. Finally, our evidence contributes to the scarce knowledge of the endocrine function in some particular events of the reproductive biology of Peromyscus melanotis, and on the reproductive biology of Peromyscus in temperate mid-latitudes.
Comparative Antiseizure Analysis of Diverse Natural Coumarin Derivatives in Zebrafish

Coumarins are a well-known group of plant secondary metabolites with various pharmacological activities, including antiseizure activity. In the search for new antiseizure drugs (ASDs) to treat epilepsy, it is yet unclear which types of coumarins are particularly interesting as a systematic analysis has not been reported. The current study performed behavioral antiseizure activity screening of 18 different coumarin derivatives in the larval zebrafish pentylenetetrazole (PTZ) model using locomotor measurements. Activity was confirmed for seven compounds, which lowered seizure-like behavior as follows: oxypeucedanin 38%, oxypeucedanin hydrate 74%, notopterol 54%, nodakenetin 29%, hyuganin C 35%, daphnoretin 65%, and pimpinellin 60%. These coumarins, together with nodakenin, underwent further antiepileptiform analysis by local field potential recordings from the zebrafish opticum tectum (midbrain). All of them, except for nodakenetin, showed pronounced antiepileptiform activity, decreasing PTZ-induced elevation in power spectral density (PSD) by 83–89% for oxypeucedanin, oxypeucedanin hydrate, and notopterol, 77% for nodakenin, 26% for nodakenetin, 65% for hyuganin C, 88% for daphnoretin, and 81% for pimpinellin. These data demonstrate the potential of diverse coumarin scaffolds for ASD discovery. Finally, the structural differences between active and inactive coumarins were investigated in silico for oxypeucedanin hydrate and byacangelicin for their interaction with GABA-transaminase, a hypothetical target.
A Comprehensive Computational Screening of Phytochemicals Derived from Saudi Medicinal Plants against Human CC Chemokine Receptor 7 to Identify Potential Anti-Cancer Therapeutics

Homeostatic trafficking of immune cells by CC chemokine receptor 7 (CCR7) keeps immune responses and tolerance in a balance. The involvement of this protein in lymph node metastasis in cancer marks CCR7 as a penitential drug target. Using the crystal structure of CCR7, herein, a comprehensive virtual screening study is presented to filter novel strong CCR7 binding phytochemicals from Saudi medicinal plants that have a higher binding affinity for the intracellular allosteric binding pocket. By doing so, three small natural molecules named as Hit-1 (1,8,10-trihydroxy-3-methoxy-6-methylanthracen-9(4H)-one), Hit-2 (4-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one), and Hit-3 (10-methyl-12,13-dihydro-[1,2]dioxolo[3,4,5-de]furo[3,2-g]isochromeno[4,3-b]chromen-8-ol) are predicted showing strong binding potential for the CC chemokine receptor 7 allosteric pocket. During molecular dynamics simulations, the compounds were observed in the formation of several chemical bonding of short bond distances. Additionally, the molecules remained in strong contact with the active pocket residues and experienced small conformation changes that seemed to be mediated by the CCR7 loops to properly engage the ligands. Two types of binding energy methods (MM/GBPBSA and WaterSwap) were additionally applied to further validate docking and simulation findings. Both analyses complement the good affinity of compounds for CCR7, the electrostatic and van der Waals energies being the most dominant in intermolecular interactions. The active pocket residue’s role in compounds binding was further evaluated via alanine scanning, which highlighted their importance in natural compounds binding. Additionally, the compounds fulfilled all drug-like rules: Lipinski, Ghose, Veber, Egan, and Muegge passed many safety parameters, making them excellent anti-cancer candidates for experimental testing.
Voice Morphing

Voice morphing is a framework to generate a new sound which has the mixed attribute of given voice examples. It provides a flexible tool for investigating perceptual attributes in voice communication, especially for quantifying paralinguistic and extralinguistic cues. Recent advances in parametric representation of speech sounds have made the morphing-based approach a practical alternative or complementary strategy to procedures using speech-production models. Stimulus continuum spanning between two typical voice recordings having different perceptual attributes provides an external reference to quantify subjective responses. Generalized morphing, which enables extrapolation as well as interpolation of arbitrarily many numbers of voices, provides a unique strategy for investigating speaker identity. Its ability to selectively manipulate any combination of fundamental parameters facilitates the development of technology to intervene and mediate paralinguistic and extralinguistic communication channels.
Pigs

– is an important factor in increasing the heat transfer efficiency. The determining factor in solving these problems when creating pasteurization equipment was the new design of the pasteurizer and its hydrodynamic characteristics, which provide minimal energy costs and stable and efficient pasteurization. Technical solutions of the scraper-plate pasteurizer provide high efficiency of high-temperature thin-layer processing of the product in the stream, structural simplicity and compactness with a developed heat exchange surface, inherent in plate heat exchangers, in combination with high turbulence of the stream, preventing the formation of burn-in inherent in scraper devices. The presence of a heat energy recuperator in the installation allows to reduce the energy consumption for pasteurization by 60%. A range of plants has been developed to complete the production lines for oil, sour cream and other milk and fat products with a productivity of 1250-5000 kg/h. of biological range of The aim of the work is to provide the scientific substantiation and developthe latest technologies of sour-milk drinks from skolotyn for all functional groups of the population using such natural prebiotics as spirulina and sprouted wheat germs. Thus, while developing and preparing this recipe we put the following tasks:to study and investigate the technological properties of spirulina and sprouted wheat germs for sour-milk drinks from skolotyn; to develop the recipe and technological scheme of the finished product;to select the correlation of microorganisms that will enhance the taste composition of the product; to study the organoleptic, physico-chemical, microbiological parameters of the finished product and to evaluate the qualitative parameters of the sour-milk drink from skolotyn. Based on the foregoing, we can say that fast rolst Queens breed combinations (EO×HR and WB×L) has no significant effect on chemical composition of meat and fat to get them to posterity. Was observed only a tendency to increase protein in the longest muscle in the back of 0.24% of gilts obtained from crossbred ewes WB×L, in comparison with their peers a combination of (EO×HR×F) (P<0.05).
RECOGNITION

This chapter begins Part III: Seeing Metagnosis, which explores the narrative arc of metagnosis itself, including the stages of recognition, subversion, and renegotiation. Here the subject is recognition, the first metagnostic stage. Beginning with the model of passing, it traces experiences and forms of recognition through real-world examples as well as those drawn from speculative fiction literature and film, particularly Blade Runner. Drawing upon recognition’s conceptualization—from Aristotle to twentieth-century science fiction editors to literary theory and criticism—it describes a form of misrecognition which characterizes, too, the experience of metagnosis, in which the terms of knowledge have shifted.
TWITTIRÒ: an Italian Twitter Corpus with a Multi-layered Annotation for Irony

Provided the difﬁculties that still affect a correct identiﬁcation of irony within the context of Sentiment Analysis tasks, in this paper we describe the main issues emerged during the development of a novel resource for Italian annotated for irony. The project mainly consists in the application on the Twitter corpus TWITTIRÒ of a multi-layered scheme for the ﬁne-grained annotation of irony, as proposed in a multilingual setting and previously applied also on French and English datasets (Karoui et al. 2017). In applying the annotation on this corpus, we outline and discuss the issues and peculiarities emerged about the exploitation of the semantic scheme for Twitter textual messages in Italian, thus shedding some lights on the future directions that can be followed in the multilingual and cross-language perspective too. We present, in particular, an analysis of the annotation process and distribution of the labels of each layer involved in the scheme. This is supported by a discussion of the outcome of the annotation carried on by native Italian speakers in the development of the corpus. In particular, an in-depth discussion of the inter-annotator agreement and of the sources of disagreement is included. The result is a novel gold standard corpus for irony detection in Italian, which enriches the scenario of multilingual datasets available for this challenging task and is ready to be used as a benchmark in automatic irony detection experiments and evaluation campaigns.
Conceptualizing ASEAN Tourism Brand: Towards A Coopetition Framework

Objective - This paper proposes an integrative framework in an attempt to conceptualize the branding of ASEAN tourism in a sustainable and unified approach based on the results collected from a sample of travellers visiting ASEAN destinations and tourism insights from NTOs or DMOs. Methodology/Technique - A mixed method is used to combine the quantitative and qualitative phases. A survey of travellers visiting ASEAN destinations (n=480) is conducted with a mix of Asian travellers and Western travellers, as well as 10 in-depth interviews with NTOs or DMOs to obtain tourism insights. Findings - The findings suggest that authenticity of the destination image is an integral part of ASEAN tourism. National Tourism Organizations (NTOs), Destination Marketing Organization (DMO) and other stakeholders of ASEAN tourism should adopt a coopetition framework and co-create a consistent and coherent positioning of the destination, while maintaining a competitive positioning of the nation, to achieve a sustainable brand of ASEAN tourism. Novelty - The paper highlights the needs for ASEAN NTOs and DMOs to enable coopetition for all tourism stakeholders for the promotion of the ASEAN brand. The proposed framework is seen as transformative in its ability to bring about collaborative and sustainable efforts to ultimately achieve an authentic ASEAN brand. Type of Paper - Empirical. Keywords: ASEAN Tourism Brand; Coopetition; Cooperation and Competition; Authenticity; NTOs; DMOs. JEL Classification: M38, M38, L32.
China

guide to British industry. London, 1960. 2, 174 p. BORRIE, WILFRED DAVIS. Population explosion and the Far East. PA 33 (June 1960), 181-91. Review article. DARBOIS, DOMINIQUE. Enfants d'Asie; photographies. Pref. de Armand Gatti. Paris, Editions Prisma [cl959] unpaged, ills. From Moscow to the flag; Sino-Japanese trade 1952-8. FEER 28 (Apr. 14, 1960), 776, 781-83, 785, 787, 789. tables. HARRIS, W. J. Oil interests in the Far East. EW 13, no. 8 (1959), 22-24. KITAMURA, HIROSHI. Economic theory and underdeveloped countries of Asia and die Far East: an Ecafe case. UA 11, no. 3 (1959), 238-40. MUELLER, F. H. Free enterprise in economic growth. Foreign commerce weekly 62 (Oct. 19, 1959), 18-19. RONA-TAS, A. Dariganga folklore texts. Act.Or. (B) 10 (I960), 171-83. SCHUBERT, J. Einige Notizen zur Erzahlung von "Geser Xan". MIODAWB 7 (1960), 382-94.