Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors influencing delayed clearance of high dose methotrexate (HDMTX) in pediatric, adolescent, and young adult oncology patients

Purpose To identify modifiable risk factors associated with prolonged clearance of methotrexate in pediatric, adolescent, and young adult (AYA) oncology patients receiving high dose methotrexate (HDMTX). Design/Method A single institution, retrospective chart review of patients receiving HDMTX between 2010-2017. Patients had a diagnosis of either leukemia or osteosarcoma. Data included demographics, concurrent intravenous (IV) medications, IV fluids (IVF) administered, urine output (UO), and rises in serum creatinine (RSC) reflective of renal toxicity (RT). Outcome measures included 1) delayed targeted MTX clearance (DC), 2) actual time to clearance (TTC) and 3) length of stay (LOS). Results Data from 447 HDMTX administrations were analyzed. The sample consisted of 241 (54%) osteosarcoma encounters, and 206 (46%) leukemia encounters, with an average patient age of 12.7 years. Multivariate analysis showed that DC was associated with the diagnosis of leukemia (OR 7.64, p <.0001), and less UO on day 1 (OR 0.76, p=0.005). Increased TTC was associated with increasing age (RR 1.02, p<0.0001), higher 24-hour MTX levels (RR 1.001, p=0.012) and 48-hour MTX levels (RR 1.02, p<0.0001), RT (RR 1.004, p<0.0001), use of IV lorazepam (RR 1.08, p=0.001) and IV metoclopramide (RR 1.08, p<0.001) both on day 3. Like TTC, LOS was affected by MTX levels at 24 (RR 1.001, p=0.025) and 48 hours (RR 1.03, p<0.0001), RT (RR 1.006, p<0.0001), total IV medications on day 3 (RR 1.042, p<0.0001), and the use of leucovorin on day 2 (RR 0.93, p=0.002). Conclusion Multiple modifiable risk factors were identified which can be leveraged to improve HDMTX clearance. Subsequent efforts will assess whether acting on such risk factors can improve MTX clearance and shorten LOS.
Pengaruh Emotional Intelligence Terhadap Organizational Citizenship Behavior (OCB) Pada Perawat Di Kota Makassar

The purpose of this study was to see the influence of emotional intelligence on Organizational Citizenship Behavior (OCB) in nurses. Respondents used in this study were nurses in Makassar City, totaling 180 people. This research uses quantitative methods. The data collection method was carried out using an adapted emotional intelligence scale and organizational citizenship behavior (OCB) scale. The analytical method used in this research is a spearman rho test. The results of this study indicate that there is a positive influence of emotional intelligence on organizational citizenship behavior (OCB) of 64,1% in nurses in Makassar City.
FISH FARMING REGIONS AS KEY ELEMENTS FOR NATURAL RECOLONISATION ALONG AN OTTER EECONET

High density otter populations currently exist in fish farming regions in central Europe. Migrating otters from these expanding populations can help recolonise depleted otter ranges in Western Europe. However, conflicts between fish farming interests and predating otters puts the latter at risk. Killing or relocating otters and large scale fencing (in effect habitat destruction) to protect fishery interests will disrupt the surplus character of these otter populations. A joint international effort is proposed to find the political and financial means to help solve this problem.
Damage extraction of buildings in the 2015 Gorkha, Nepal earthquake from high-resolution SAR data

Satellite remote sensing is recognized as one of the effective tools for detecting and monitoring affected areas due to natural disasters. Since SAR sensors can capture images not only at daytime but also at nighttime and under cloud-cover conditions, they are especially useful at an emergency response period. In this study, multi-temporal high-resolution TerraSAR-X images were used for damage inspection of the Kathmandu area, which was severely affected by the April 25, 2015 Gorkha Earthquake. The SAR images obtained before and after the earthquake were utilized for calculating the difference and correlation coefficient of backscatter. The affected areas were identified by high values of the absolute difference and low values of the correlation coefficient. The post-event high-resolution optical satellite images were employed as ground truth data to verify our results. Although it was difficult to estimate the damage levels for individual buildings, the high resolution SAR images could illustrate their capability in detecting collapsed buildings at emergency response times.
Circularized Nanodiscs for Multivalent Mosaic Display of SARS-CoV-2 Spike Protein Antigens

The emergence of vaccine-evading SARS-CoV-2 variants urges the need for vaccines that elicit broadly neutralizing antibodies (bnAbs). Here, we assess covalently circularized nanodiscs decorated with recombinant SARS-CoV-2 spike glycoproteins from several variants for eliciting bnAbs with vaccination. Cobalt porphyrin–phospholipid (CoPoP) was incorporated into the nanodisc to allow for anchoring and functional orientation of spike trimers on the nanodisc surface through their His-tag. Monophosphoryl-lipid (MPLA) and QS-21 were incorporated as immunostimulatory adjuvants to enhance vaccine responses. Following optimization of nanodisc assembly, spike proteins were effectively displayed on the surface of the nanodiscs and maintained their conformational capacity for binding with human angiotensin-converting enzyme 2 (hACE2) as verified using electron microscopy and slot blot assay, respectively. Six different formulations were prepared where they contained mono antigens; four from the year 2020 (WT, Beta, Lambda, and Delta) and two from the year 2021 (Omicron BA.1 and BA.2). Additionally, we prepared a mosaic nanodisc displaying the four spike proteins from year 2020. Intramuscular vaccination of CD-1 female mice with the mosaic nanodisc induced antibody responses that not only neutralized matched pseudo-typed viruses, but also neutralized mismatched pseudo-typed viruses corresponding to later variants from year 2021 (Omicron BA.1 and BA.2). Interestingly, sera from mosaic-immunized mice did not effectively inhibit Omicron spike binding to human ACE-2, suggesting that some of the elicited antibodies were directed towards conserved neutralizing epitopes outside the receptor binding domain. Our results show that mosaic nanodisc vaccine displaying spike proteins from 2020 can elicit broadly neutralizing antibodies that can neutralize mismatched viruses from a following year, thus decreasing immune evasion of new emerging variants and enhancing healthcare preparedness.
Traffic Flow Data Mining and Evaluation Based on Fuzzy Clustering Techniques

Effective mining technology can extract the spatial distribution pattern of the road network traffic flow. In this paper, the similarities between traffic flow objects with spatial temporal characteristics were measured by introducing the Dynamic Time Warping (DTW) and the shortest path analysis method. We proposed a new fuzzy clustering algorithm for road network traffic flow data. So that traffic flow data objects with similar properties and space correlation are clustered into a group, which find the spatial distribution pattern of road traffic flow. The experimental results show that the method was valid and effective. The road network was classified reasonably, and classification results could provide traffic zone division with decision auxiliary support.
Shaping Ability of a Novel Rotary Nickel Titanium System using Cone Beam Computed Tomography (An Invitro Study)

Background: Cleaning & Shaping is the most important aspect of successful endodontic treatment. Root canal curvatures pose a challenge to maintain its curvature with achieving adequate cleaning and shaping. Aim of the work: Our study was conducted to evaluate the shaping ability of three rotary files: Endo plus files. M-Pro files. Protaper Universal; regarding change in canal curvature, canal transportation and centering ratio. Materials and Methods: Thirty mesiobuccal canals in thirty mesiobuccal roots of mandibular permanent first molars were divided into 3 groups where each group will be instrumented by a file system; Group (A) shaped by Endo Plus Files, Group (B) shaped by M Pro files, Group (C) shaped by Protaper files. Teeth were scanned using CBCT before and after instrumentation, each group with its respective file system, where both scans are superimposed via software and measurements were extracted at 3 vertical levels and analyzed. Results: Data : Data was analysed using one-way ANOVA. P ≤ 0.05 was considered as the level of significance.There was no statistically significant difference between the three file file systems, in terms of evaluation of angle of curvature (P = 0.120), Canal Transportation (P = 0.112), Centring Ratio (P = 0.149). Conclusion: Under the circumstances of this study, it can be concluded that there is no statistical difference between the overall shaping ability of the three file systems regarding the evaluation of change of angle of curvature, canal transportation and centering ability despite the minor difference in performance at different vertical levels.
Survey on the Mental Health of Dispensing Pharmacists in the Auvergne-Rhône-Alpes Region (France)

Background: The COVID-19 pandemic intensely involved pharmacists in France, with new responsibilities on a large scale, introducing to dispensary practice the performance of vaccination and nasopharyngeal swabs. This study aimed to assess the prevalence of burnout, anxiety, and depression in pharmacists after the COVID-19 health crisis and to identify factors associated with psychological distress. Methods: A cross-sectional observational study involved 1700 pharmacies in an entire French region. Sociodemographic, geographical, and medical information (burnout tested with the MBI and anxiety/depression measured on the HAD scale) were collected via an online anonymous self-administered questionnaire. The characteristics of the pharmacy and the practice of antigen testing and vaccination were requested. Quantitative and qualitative variables associated with psychological distress were investigated with a factor analysis. Results: In total, 360 responses were collected (20.5%). Of the responses, 41.9% showed definite anxiety symptoms and 18.3% showed proven depressive symptoms. Three clusters were described according to the intensity of burnout experience, depersonalization, and loss of personal accomplishment. The analysis identified that one cluster was at high risk of burnout (high burnout and depersonalization scores). Of these stressed, exhausted pharmacists, 69.3% showed definite anxiety, 37.9% showed proven depression, and in smaller pharmacies. The carrying out of antigenic testing and anti-COVID vaccination, as well as the geographical location of the pharmacy, were not discriminating factors in these three groups. Conclusion: Mental health care and suicide prevention should be provided to at-risk pharmacists. It seems essential to publicize the range of resources available to support pharmacists.
Effects of Virtual Reality-Based Cognitive Rehabilitation in Stroke Patients: A Randomized Controlled Trial

During the process of recovering functional ability after damage caused by a stroke, it is important to restore cognitive function via cognitive rehabilitation. To achieve successful rehabilitation, it is important for patients to have a sense of efficacy in their ability to manage their disease well. Therefore, a virtual reality-based cognitive rehabilitation program based on self-efficacy theory was developed, and its effects were compared with conventional and computer-assisted cognitive rehabilitation. The virtual reality-based cognitive rehabilitation program consisted of sessions lasting 30 min each five days a week for eight weeks. After applying the virtual reality-based cognitive rehabilitation program, there were significant differences in group-by-time interactions regarding stroke self-efficacy, cognitive function, visual perception, activities of daily living, and health-related quality of life. In addition, there were significant group differences among the three groups in terms of stroke self-efficacy and health-related quality of life. In conclusion, our virtual reality-based cognitive rehabilitation program developed based on self-efficacy theory is effective for inpatients with stroke and improves their stroke self-efficacy, cognitive function, visual perception, activities of daily living, and health-related quality of life.
IPCC special report on carbon dioxide capture and storage

Foreword Preface Summary for Policymakers Technical Summary 1. Introduction 2. Sources of CO2 3. Capture of CO2 4. Transport of CO2 5. Underground geological storage 6. Ocean storage 7. Mineral carbonation and industrial uses of carbon dioxide 8. Costs and economic potential 9. Implications of carbon dioxide capture and storage for greenhouse gas inventories and accounting Annex I. Properties of CO2 and carbon-based fuels Annex II. Glossary, acronyms and abbreviations Annex III. Units Annex IV. Authors and Expert Reviewers Annex V. List of IPCC publications.
IMAGE TEXTURE: AN UNTAPPED RESOURCE FOR ESTIMATING FOREST BIOPHYSICAL PARAMETERS?

Methods with increased efficiency for estimating forest biophysical parameters are continually required to improve inventory information that underpins conservation planning and sustainable utilisation of forests for multiple benefits. Previous methods for vegetation structural complexity mapping have not been adopted for operational monitoring because these approaches employed techniques that are prohibitively expensive to apply across regional areas and/or were unable to simultaneously account for stochastic and deterministic factors influencing vegetation structural complexity. This research explored the value of spatial information derived form satellite imagery for improving predictions of within-stand variations in structural complexity using a case study of dry sclerophyll forests on the Southern Tablelands of New South Wales, Australia. Relationships between spectral and spatial information from satellite imagery, along with abiotic environmental variables, were compared to field measurements of a structural complexity index and biophysical parameters using regression analysis. The inability of models to explain the majority of variation in forest attributes and the common selection of abiotic environment variables as explanatory variables in models over, particularly textural, variables derived from remotely sensed imagery was attributes to the sub-optimal spatial resolution of imagery relative to the vegetation target. Spatial estimates of the McElhinny structural complexity index and forest stand attributes from the predictive models are still useful for the operational management and monitoring by natural resource managers who require information on the relative structural complexity of native vegetation stand within the landscape.
Floristic Composition and Change in Species Diversity over Long Temporal Scales in Upper Bhotekoshi Hydropower Project Area in Nepal

Forest and vegetation of particular ecosystem is generally influenced by external factors especially from development activities. Nepal has been endowed with an immense variety of forest resources with its unique biodiversity. The current study is conducted in the temperate forest of central Nepal to compare the state of vegetation recorded during 1995 with the present condition. To identify floristic composition, species distribution and diversity, same location and same size of quadrates were selected in natural forest and planted or regenerated area as in previous study. Measurement and analytical tools for forest and vegetation reveled a total of 19 species and 341 individuals in 0.14 ha regenerated area and 18 species, 17 genera and 260 individuals in 0.16 ha, natural forest areas. However, in 1995, total 31 individuals of 20 woody species, 18 genera and 15 families were recorded within the sampling plots of 0.16 ha of natural forest. Moreover, Alnus nepalensis is found dominating regenerated area and Caryopteris odorata in natural forests whereas in 1995, Litsea chartacea and Maesa chisia were recorded dominant. The Shannon’s diversity H’ = 2.908, E = 0.970 and Var H’ = -0.00 and Simpsons D = 0.027 recorded in 1995 is found to be with higher values when compared with the analysis of present study. Furthermore, in comparison to 1995 study, this study showed lower basal area and timber volume with declining species diversity. Although, the natural forest is found with higher species composition compared to rehabilitated forest, species of herbs and shrubs were found extensively growing.
Extraction of Features from a Bird's-Eye View for Path Detection

: Path detection has emerged as a complex challenge that has garnered significant attention within the computer vision community for a considerable span. The foundational problem of recognizing routes has evolved into a substantial impediment in the realm of computer vision. While a variety of Deep Learning methods have been employed for route identification, the focus has often centered on feature generation. Nonetheless, advanced Deep Learning techniques have exhibited proficiency in discerning these attributes. Yet, the complete implementation of these approaches to efficiently and accurately identify lanes is still pending. In this paper, we introduce an innovative perspective to address this issue. A distinctive approach to route preprocessing, coupled with a bird's-eye view, is presented. The primary aim involves the selection of the bird's-eye view area based on the processed image. Subsequently, an HSL (hue, saturation, and lightness) color transformation is applied to extract white features, along with a unique preliminary edge feature detection method. The lane is then identified using this new preprocessing strategy. It is noteworthy that numerous prior works have drawn upon the same standard datasets.
Mobilizing Wood Resources: Can Europe's Forests Satisfy the Increasing Demand for Raw Material and Energy Under Sustainable Forest Management? Workshop proceedings, Geneva, Switzerland, January 2007.

These proceedings, from the January 2007 workshop Mobilizing Wood Resources, provide background information and summarize the main prese ntations given at the event as well as the discussi on . They also present the strategies and recommendation s fr m the working groups on how to mobilize additional wood resources in Europe to meet the nee ds of wood manufacturers, who want to remain vital and competitive, and the bioenergy sector, who would li ke to produce more energy from carbon neutral sourc es such as wood.
Overview on Pediatric Obesity Hypoventilation Syndrome

The relationship between obesity and the onset of persistent daytime alveolar hypoventilation is known as obesity hypoventilation syndrome. This illness results from a complicated interaction between sleep-disordered breathing, reduced respiratory drive, and obesity-related respiratory impairment, and is associated with considerable morbidity and mortality. Extreme obesity has become far more common in the United States and other nations during the past three decades. The prevalence of OHS will inevitably rise considering the global obesity pandemic. When compared to people with sleep apnea, patients with OHS have a poorer quality of life, incur higher medical costs, and are more likely to develop pulmonary hypertension and die young. Even though this illness is associated with severe morbidity and mortality, it is commonly overlooked, and treatment is typically postponed. Clinicians need to keep a high index of suspicion since this syndrome carries a heavy burden of morbidity and mortality, which is reduced by early diagnosis and treatment. The definition and clinical presentation of OHS, a brief overview of its prevalence, a review of current understanding of pathophysiology, and discussion of recent developments in therapeutics will all be included in this review.
COMPARISON OF KEROGEN MATURATION AND ILLITE/SMECTITE COMPOSITION IN DIAGENESIS

Kerogen maturation, estimated from pyrolysis Tmax values, is compared with the smectite layer-content of the illite/smectite mineral derived from sediments in six suites from different basins with different ranges of stratigraphic age. The most significant correlations are made when comparing Tmax and estimated percentage kerogen transformation with sample age for the same smectite layer-content (iso-smectite content or stage of clay maturation). The percentage transformation of Type III kerogen and smectite layer-content shows a regular relationship at the end of the clay reaction series (10% smectite content), which includes the oil and gas potential range for sediments in the 200 - 100 MM year age groups. Relations between less mature, more smectitic illite/smectite clay minerals and kerogen maturation are not at present clear.
Snakes from the Leeward Group, Venezuela and eastern Colombia

Dr. P. Wagenaar Hummelinck entrusted me with the study of the snakes, which he collected during his trips to the islands off the north coast of Venezuela, to the Venezuelan mainland, and to eastern Colombia. In the present paper the species collected by Dr. Hummelinck are listed with data on scale counts, coloration and with notes on nomenclature. In a few cases specimens from other collections were used for comparison, and for these the provenance is indicated in the lists of specimens. Dr. Hummelinck made notes on the names given to the different species of snakes by the inhabitants, and by his kind permission these notes are included in the present paper. These local names form an addition to those published by Roca (1932, pp. 387—388). Unless otherwise stated the specimens are in the collections of the Rijksmuseum van Natuurlijke Historie, Leiden. The numbers cited for the different specimens, Oph. 1—60, are the numbers used by the collector; they are mentioned in parentheses, the first of each list of specimens with the indication Oph. , the following without this indication.
Hydroxyethyl Cellulose-Based Hydrogels as Controlled Release Carriers for Amorphous Solid Dispersion of Bioactive Components of Radix Paeonia Alba

Radix Paeoniae Alba (RPA) has been used extensively in Chinese traditional medicine to treat gastrointestinal disorders, immune-modulating diseases, cancers, and numerous other conditions. A few of its active components include paeoniflorin, albiflorin, lactiflorin, and catechin. However, their therapeutic effectiveness is compromised by poor pharmacokinetic profiles, low oral bioavailability, short half-lives, and poor aqueous solubility. In this study, hydroxyethyl cellulose-grafted-2-acrylamido-2-methylpropane sulfonic acid (HEC-g-AMPS) hydrogels were successfully prepared for the controlled release of Radix Paeonia Alba-solid dispersion (RPA-SD). A total of 43 compounds were identified in RPA-SD using UHPLC-Q-TOF-MS analysis. The hydrogel network formation was confirmed by FTIR, TGA, DSC, XRD, and SEM. Hydrogels’ swelling and drug release were slightly higher at pH 1.2 (43.31% swelling, 81.70% drug release) than at pH 7.4 (27.73% swelling, 72.46% drug release) after 48 h. The gel fraction, drug release time and mechanical strength of the hydrogels increased with increased polymer and monomer concentration. Furthermore, the hydrogels were porous (84.15% porosity) and biodegradable (8.9% weight loss per week). Moreover, the synthesized hydrogels exhibited excellent antimicrobial and antioxidative properties.
Role of race in oncogenic driver prevalence and outcomes in lung adenocarcinoma: Results from the Lung Cancer Mutation Consortium

The discovery of oncogenic drivers has ushered in a new era for lung cancer, but the role of these mutations in different racial/ethnic minorities has been understudied. The Lung Cancer Mutation Consortium 1 (LCMC1) database was investigated to evaluate the frequency and impact of oncogenic drivers in lung adenocarcinomas in the racial/ethnic minority patient population.