Miracle-dz/UniFAR-FTUs huggingface dataset:
An identity for triplets of double Hilbert transforms, with applications to the attenuated Radon transform

We consider an elementary identity for double singular integrals in the plane and show that one can apply this to deduce inversion and product formulae for the Hilbert transform and inversion formulae for the affine and weighted Radon transforms. We will be able to allow many of the previously known weights for which there is an inversion formula for the weighted Radon transform and also pose some new conditions on which weights that can be used.
Effectiveness of ultrasonography-guided cardiac sympathetic denervation in acute control of electrical storm: A retrospective case series

Background and Aims: Ultrasonography-guided left cardiac sympathetic denervation (LCSD) or bilateral cardiac sympathetic denervation (BCSD) may be a useful intervention in the electrical storm (ES) that persists despite pharmacological therapy. The aim of our study was to evaluate the effectiveness of ultrasonography-guided LCSD or BCSD in the acute control of ES. We conducted a retrospective case series of patients who underwent ultrasonography-guided CSD for control of ES at a tertiary care hospital. Material and Methods: Data of all patients who underwent unilateral or bilateral CSD were collected from January 2017 to December 2019. Eleven patients with ES refractory to standard antiarrhythmic therapy underwent ultrasonography-guided pharmacological CSD (eight underwent LCSD and three underwent BCSD). Quantitative data was expressed as mean and median with interquartile range (IQR). Non-quantitative data was expressed in proportions. Results: Eleven patients underwent ultrasonography-guided pharmacological CSD (eight underwent LCSD and three underwent BCSD). Six of the eleven patients were female (54.5%). Ischemia was the underlying substrate in nine patients (81.8%). Five patients (46%) had complete resolution of ventricular tachycardia (VT) after CSD and one had 90% reduction in episodes of VT. The median follow-up duration was 8 months inter-quartile range IQR (7–18). One patient succumbed to heart failure and one patient was lost to follow up. The other patients had no further events and were well at last follow up. Conclusion: Ultrasonography-guided pharmacological CSD is effective in the acute control of ES. It is easily performed with equipment that is readily available and relatively safe in terms of immediate complications and is an ideal second-line intervention when ES persists despite drug therapy.
A high-repetition-rate laser-wakefield accelerator for studies of electron acceleration

We report on an experimental demonstration of laser wake field electron acceleration using few-milijoule laser pulses tightly focused on a 100 μm scale gas target. Using a comparatively low energy pulse has the benefit of a more compact system with a high repetition rate (typically kHz), which can prove useful for both practical applications and better statistical studies of laser plasma interactions. A proof-of-principle experiment was conducted to demonstrate the applicability of such electron sources from laser plasma wake field accelerator for ultrafast electron diffraction.
Improved Split TEV GPCR β-arrestin-2 Recruitment Assays via Systematic Analysis of Signal Peptide and β-arrestin Binding Motif Variants

G protein-coupled receptors (GPCRs) are major disease-relevant drug targets; robust monitoring of their activities upon drug treatment is key to drug discovery. The split TEV cell-based assay technique monitors the interaction of an activated GPCR with β-arrestin-2 through TEV protein fragment complementation using a luminescent signal as the readout. In this work, split TEV GPCR β-arrestin-2 recruitment assays were optimized to monitor the endogenous ligand-induced activities of six GPCRs (DRD1, DRD2, HTR2A, GCGR, AVPR2, and GLP1R). Each GPCR was tested in four forms; i.e., its wildtype form, a variant with a signal peptide (SP) to facilitate receptor expression, a variant containing the C-terminal tail from the V2 vasopressin receptor (V2R tail) to promote β-arrestin-2 recruitment, and a variant containing both the SP and V2R tail. These 24 GPCR variants were systematically tested for assay performance in four cell lines (HEK-293, PC12 Tet-Off, U-2 OS, and HeLa). We found that the assay performance differed significantly for each GPCR variant and was dependent on the cell line. We found that V2R improved the DRD2 split TEV assays and that HEK-293 cells were the preferred cell line across the GPCRs tested. When taking these considerations into account, the defined selection of assay modifications and conditions may improve the performance of drug development campaigns that apply the split TEV technique as a screening tool.
The Gasdynamics of Compact Relativistic Jets

The gasdynamics of compact relativistic jets is explored by analyzing a specific idealized flow problem using the method of characteristics. The basic flow pattern of the gas and pressure waves within a jet experiencing a drop in external pressure is calculated, with analytic expressions given for many of the important parameters. Scaling laws which relate the intrinsic properties of the jet to the pressure of the surrounding medium are obtained and discussed. The physical properties of the jet depend critically on the value and abruptness of the decrease in external pressure, as well as on the initial Lorentz factor of the flow. A variety of the flow patterns can result, including jets of oscillating cross section, jets with standing shocks, and broad, nearly hollow beams which can break up into multiple jets. These results are discussed in relation to the observed characteristics of superluminal radio sources in general and the superluminal quasar 4C 39.25 in particular. 25 references.
The Role of Prognostic Nutrition Index in Predicting Hospitalization of Patients With Heart Failure With Mildly Reduced Ejection Fraction

Background The prognostic nutritional index (PNI), consisting of albumin and lymphocyte counts, has been associated with satisfactory predictive values for in-hospital mortality or clinical follow-up outcomes in acute situations. In this study, we aimed to evaluate the use of PNI for the prediction of hospital admission in individuals with mildly reduced ejection fraction heart failure (HFmrEF). Methodology This retrospective study was conducted between January 2019 and May 2022 and included 200 patients with HFmrEF detected by transthoracic echocardiography. Data from hospitalized patients (group 1) and outpatients (group 2) were compared. Results In the multivariable regression analysis, brain natriuretic peptide (odds ratio (OR) = 1.001; 95% confidence interval (CI) = 1.000-1.001, p = 0.001) and PNI (OR = 0.783; 95% CI = 0.720-0.853; p < 0.001) were independent predictors of hospital admission in patients with HFmrEF. The PNI value was statistically significantly higher in group 2 (52.36 ± 5.36) than in group 1 (38.3 ± 8.63, p < 0.001). The PNI value <46.75 is a predictor of hospitalization in patients with HFmrEF, with 86% sensitivity and 88% specificity. Conclusions Lower PNI levels predict hospital admission in HFmrEF patients. This measure, which can be easily evaluated in daily cardiological practice, allows for quick and precise decisions for hospitalization.
An Experimental Study of the Connection Between the Hydrodynamic and Phase-Transition Descriptions of the Couette-Taylor Instability

The Laser Doppler Velocimetry technique has been used to measure the radial flow velocity in the Taylor vortex flow at several Taylor numbers close to and above the critical value. The first four harmonics of the flow field have been analyzed using a model described by Davey. Our analysis demonstrates in a unique way that the amplitude of the first harmonic of the super-critical flow field can be regarded as the "order parameter" of the transition from the laminar Couette flow to the Taylor vortex flow. This transition is described by a generalized Landau theory for classical second order mean-field phase transitions. The analysis of the results of carefully performed experiments not only confirms the findings of earlier experimental work, but in addition we determine all the significant parameters of the full Davey model for this hydrodynamic instability.
Comparison of intranasal and nebulized dexmedetomidine for premedication in pediatric patients: A non-inferiority randomized controlled trial

Background and Aims: Dexmedetomidine is a highly selective α-2 adrenoreceptor agonist and has been found to be an effective premedication agent when administered via the intranasal route. We aimed to compare the efficacy of dexmedetomidine premedication administered via intranasal route and through nebulization in pediatric patients. Material and Methods: This non-inferiority randomized controlled trial was conducted after getting approval from institutes ethics committee and informed written parental consent. Sixty-four children aged 2-8 years scheduled for elective surgery under general anesthesia were enrolled and were divided into two groups. Group I (Intranasal, n = 33) received 2 mcg/kg dexmedetomidine via intranasal route and group N (Nebulized, n = 31) received 2 mcg/kg dexmedetomidine through nebulization. The primary outcome was number of patients with satisfactory sedation 30 minutes after premedication at separation from parent. The secondary outcome included ease of medication acceptance, anxiety at parental separation, acceptance of anesthesia mask, perioperative hemodynamics, emergence agitation during recovery and adverse effects. Data collected was analyzed using Chi-square test, Student “t” test and Mann-Whitney U test with the help of SPSS 22. A one tailed P value < 0.025 was considered significant. Results: Demographic profile was comparable between groups. On arrival in OR 27 (81.8%) patients in group I and 21 (67.7%) patients in group N had satisfactory sedation score (P = 0.19). The median (IQR) sedation score was comparable between group I and group N (P = 0.057). Patients in Group I showed significantly better medication and mask acceptance scores (P < 0.0001, P = 0.001 respectively), parental separation anxiety score (P < 0.0001) and emergence agitation score (P = 0.001). There were no significant differences in hemodynamic parameters and adverse effects between the groups. Conclusion: Although nebulized dexmedetomidine is non-inferior to intranasal dexmedetomidine in providing desired level of sedation but intranasal administration had better acceptance of medication and anesthesia mask with lesser anxiety at parental separation and postoperative emergence agitation.
Quantum theory and measurement

The forty-nine papers collected here illuminate the meaning of quantum theory as it is disclosed in the measurement process. Together with an introduction and a supplemental annotated bibliography, they discuss issues that make quantum theory, overarching principle of twentieth-century physics, appear to many to prefigure a new revolution in science.Originally published in 1983.The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These paperback editions preserve the original texts of these important books while presenting them in durable paperback editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Revisitando las variables que condicionan la neuroplasticidad asociada a la interpretación musical

El entrenamiento musical reiterado puede modificar el cerebro tanto anatómicamente como en su función, pero existen una serie de variables que condicionan la neuroplasticidad. Este texto realiza una revisión actualizada sobre ellas, revisitándolas incluyendo las últimas investigaciones en el campo de la neurociencia de la música. Entre las variables de interés, se encuentran las diferencias individuales, el sexo, la lateralidad manual, la habilidad de oído absoluto, el instrumento que se interpreta, el tipo de formación musical que recibe el intérprete, las particularidades del entrenamiento –como la intensidad del mismo o la edad de inicio, por ejemplo–, además de otros factores ambientales y genéticos.
Relations for Clebsch–Gordan and Racah coefficients in suq(2) and Yang–Baxter equations

Relations are exploited among Clebsch–Gordan (CG) and Racah coefficients in the algebra suq(2), known as a deformation of su(2). These are used to show that the Yang–Baxter (YB) relation for the IRF (interaction round a face) model results from one of the symmetry relations for the 9‐j symbol specific to suq(2), and that in an asymptotic limit this YB relation becomes the YB relation for the two‐dimensional vertex model. The Racah coefficient, which has a particularly simple dependence on q, is efficiently used such that an asymptotic limit of the Racah coefficient is the CG coefficient and another limit gives the factorized S matrix of the vertex model.
The effect of prone positioning on surgical pleth index in patients undergoing spine surgery under general anesthesia – A prospective observational study

Background and Aims: Surgical Pleth Index (SPI) provides an objective assessment of nociception - anti-nociception balance but is influenced by multiple confounders. The effect of change of position on SPI, has not been studied extensively. The aim of the study was to observe the effect of prone positioning on SPI and its correlation with hemodynamic variables, in patients undergoing lumbar and thoracic spine surgery. Material and Methods: This prospective observational pilot study included 14 patients. In addition to hemodynamic monitoring, SPI, entropy and pulse pressure variability (PPV) were monitored. Propofol and Fentanyl infusions were used for maintenance of anesthesia. The patients were made prone on bolsters and all the variables were recorded every 5 minutes in supine position and after making prone for 20 minutes, before and after incision, muscle splitting and laminectomy. Results: Comparing the last value of the variables in the supine position with those immediately after making prone, SPI increased by 16.36 units (P = 0.003), followed by gradual reduction over the next 20 minutes. Mean arterial pressure and heart rate increased transiently (Pvalue = 0.028 and 0.025, respectively) without any significant change in PPV. Surgical incision also led to a significant increase in SPI. Conclusion: Prone positioning leads to significant increase in SPI, probably due to increased sympathetic tone.
Genomic diversification of the specialized parasite of the fungus-growing ant symbiosis

Significance Fungi represent a kingdom of organisms with diverse interspecies associations and broad variability in genome content. The fungal genus Escovopsis is a parasite of the multipartite fungus-growing ant symbiosis. We present this genus as a eukaryotic model of genomic reduction and diversification over the 60-million-year-old history of the fungus-growing ant symbiosis. This genomic evolution represents an example of a eukaryotic genus evolving a reduced genomic toolkit while maintaining ancient host associations.
Bi on graphite : Morphology and growth characteristics of star-shaped dendrites

The growth of bismuth islands on highly ordered pyrolitic graphite substrates has been investigated as a function of flux and coverage, at room temperature. Island growth proceeds via homogeneous nucleation, and subsequent aggregation at a fixed height of {approx}1 nm, giving a two-dimensional growth mode with a lateral growth rate that is independent of coverage and depends only on the flux, within the range of this study. In the low flux regime, the morphologies are characterized by elongated six-pointed stars with well defined stripelike structures aggregated on top of the islands.
Spinal Cord Stimulator Therapy as a Last Resort Option in Refractory Neuropathic Groin Pain: A Case Report

A spinal cord stimulator (SCS) is an excellent therapeutic strategy for many refractory chronic pain cases. They have a multi-faceted effect in providing relief in such indicated cases that include complex regional pain syndrome (CRPS) or failed back surgery syndrome (FBSS). However, if a patient has chronic intractable neuropathic pain outside the standard indications for SCS, can a case be made for trialing SCS as a last resort option? We describe a case where a patient with neuropathic groin pain, refractory to numerous types of procedures and non-interventional modalities, successfully underwent SCS therapy as a last resort option.
Large-scale prediction of adverse drug reactions-related proteins with network embedding

Abstract Motivation Adverse drug reactions (ADRs) are a major issue in drug development and clinical pharmacology. As most ADRs are caused by unintended activity at off-targets of drugs, the identification of drug targets responsible for ADRs becomes a key process for resolving ADRs. Recently, with the increase in the number of ADR-related data sources, several computational methodologies have been proposed to analyze ADR–protein relations. However, the identification of ADR-related proteins on a large scale with high reliability remains an important challenge. Results In this article, we suggest a computational approach, Large-scale ADR-related Proteins Identification with Network Embedding (LAPINE). LAPINE combines a novel concept called single-target compound with a network embedding technique to enable large-scale prediction of ADR-related proteins for any proteins in the protein–protein interaction network. Analysis of benchmark datasets confirms the need to expand the scope of potential ADR-related proteins to be analyzed, as well as LAPINE’s capability for high recovery of known ADR-related proteins. Moreover, LAPINE provides more reliable predictions for ADR-related proteins (Value-added positive predictive value = 0.12), compared to a previously proposed method (P < 0.001). Furthermore, two case studies show that most predictive proteins related to ADRs in LAPINE are supported by literature evidence. Overall, LAPINE can provide reliable insights into the relationship between ADRs and proteomes to understand the mechanism of ADRs leading to their prevention. Availability and implementation The source code is available at GitHub (https://github.com/rupinas/LAPINE) and Figshare (https://figshare.com/articles/software/LAPINE/21750245) to facilitate its use. Supplementary information Supplementary data are available at Bioinformatics online.
Relative velocity in pseudo-Riemannian spacetime

We give a coordinate independent definition of relative velocity of test particle in pseudo-Riemannian spacetime as measured along the observer’s line-of-sight in general and several instructive cases. In doing this, the test particle is considered as a luminous object, otherwise, if it is not, we assume that a light source is attached to it, which has neither mass nor volume. Then we utilize the general solution of independent definition of relative velocity of a luminous source in generic pseudo-Riemannian spacetime. As a corollary, we discuss the implications for the Minkowski metric, the test particle and observer at rest in an arbitrary stationary metric, the uniform gravitational field, the rotating reference frame, the Schwarzschild metric, the Kerr-type metrics, and the spatially homogeneous and isotropic Robertson-Walker (RW) spacetime of standard cosmological model. In the last case, it leads to cosmological consequence that the resulting, so-called, kinetic recession velocity of an astronomical object is always subluminal even for large redshifts of order one or more, so that it does not violate the fundamental physical principle of causality. We also calculate the measure of carrying away of a galaxy at redshift z by the expansion of space, which proves, in particular, that cosmological expansion of a flat 3D–space is fundamentally different from a kinematics of galaxies moving in a non-expanding flat 3D-space. So, it is impossible to mimic the true cosmological redshift by a Doppler effect caused by motion of galaxies in a non-expanding 3D-space, flat or curved. We also give a reappraisal of the `standard ́ kinematic interpretation of redshifts in RW spacetime as accumulated Doppler-shifts.
Effects of different parameters on attenuation rates in circular and arch tunnels

Radio wave propagation in circular and arch shaped cross-section tunnels is analyzed. The electrical and mechanical parameters, such as the shape and transverse dimension of the tunnels, frequency, polarization, electrical parameters like conductivity and permittivity, which have a significant influence on the attenuation inside tunnels are determined. The impact of these parameters on the propagation is analyzed and an optimum set of values is determined. In this paper, taking circular and arch shaped tunnel as an examples, influence of various parameters on UHF radio propagation is analyzed.
Using Local Orientational Information As Image Primitive For Robust Object Recognition

Orientational information can replace the traditional edges as basic image features ("primitives") for object recognition. A comparison of five different orientation operators on 3 x 3 windows is carried out, and it is found that these operators have similar performance. A first attempt at object recognition searches for minimum root mean square deviation of orientation in a picture. This technique shows better object discrimination than the traditional normalized cross-correlation of grey-level images. Additionally the parameters of the Gaussian distribution of orientational correlation can be accurately predicted by a simple theoretical model. The orientational correlation technique shows difficulties in recognizing geometrically distorted and partially occluded objects. For this reason a very robust algorithm for the recognition of simple objects is developed, based only on orientationl information as image feature, and local polar coordinates for the model of the object. Practical examples taken under difficult, natural conditions illustrate the reliable performance of the proposed algorithm, and it becomes apparent that orientational information is indeed a powerful image primitive.
Rotating magneto-convection: Influence of vertical magnetic field

In the present numerical study the effect of a vertically applied magnetic field on convection of low Prandtl number liquid metal, rotating in a cubical cavity of aspect-ratio 8:8:1 has been investigated. The bottom wall is heated while the top wall is cooled and all the other walls are kept thermally insulated. The simulations have been carried out for liquid metal flows having a fixed Prandtl number Pr = 0.01, Rayleigh number Ra = 107 and magnetic Prandtl number Pm = 4.0 × 10−4, while the Chandrasekhar number Q varies from 5.0625 × 104 to 4.9 × 105 and the Taylor number Ta is varied from 0 to 1010. It is found that the magnetic field generates a strong damping effect on flow velocities and heat transfer at low rotation rates corresponding to Ta = 106 and Ta = 2.5 × 107, though at higher rotation rates Ta = 1010 the Coriolis forces become comparable to the Lorentz forces thus generating conditions conducive for incipience of dynamo. At the same Ta, with an increase in magnetic fields corresponding to Qh = 4.9 × 105 there is a sharp fall in rms velocities near the top and bottom walls due to the formation of thin Hartmann layers. At low rotation rates, vertically stretched multi-cellular rolls perpendicular to the gravity axis are found. As the rotation increases, the rolls change their spatial orientation and align themselves parallel to the rotation axis. At the highest rotation rate Ta = 1010, a cylindrical vortical column forms at the centre of the cavity.