Miracle-dz/UniFAR-FTUs huggingface dataset:
Importance of Gedunin in Antagonizing Rheumatoid Arthritis via Activating the Nrf2/ARE Signaling

Objective This study assessed the anti-arthritic effect and protection of Gedunin (GDN) on joint tissues and revealed the possible mechanism in suppressing rheumatoid arthritis (RA). Methods LPS-induced macrophages and TNF-α-stimulated synovial fibroblasts (MH7A) or IL-1β-stimulated primary rheumatoid arthritis synovial fibroblasts (RASFs) were used to evaluate the antiinflammatory effect of GDN. In addition, CIA-induced arthritis was employed here to evaluate the anti-arthritic effect. MTT and BRDU assays were utilized to evaluate the cell viability and proliferation, Q-PCR was conducted to detect the mRNA expression of cytokines, FACS was adopted to monitor ROS production, while western blotting (WB) and siRNA interference were applied in confirming the anti-arthritic effects of GDN via the Nrf2 signaling. Results. In vitro, cell viability was inhibited in macrophages and MH7A cells, but not in RASFs; but the proliferation of RASFs was significantly suppressed in time- and dose-dependent manners. GDN suppressed cytokine levels in LPS-stimulated macrophages and TNF-α-stimulated MH7A cells or RASFs. GDN suppressed ROS expression. Furthermore, GDN treatment notably dose-dependently decreased the mRNA and protein expression of iNOS in LPS-induced macrophages. sip62 interference results showed that GDN cause the less expression of HO-1 and Keap1 and also fail to inhibit cytokines after sip62 interference. In vivo, GDN effectively inhibited paw swelling, arthritis score, and arthritis incidence and cytokines. Conclusions Our study suggested that GDN exhibited strong antagonistic effect on arthritis both in vitro and in vivo via activation of Nrf2 signaling. Our work will provide a promising therapeutic strategy for RA.
Design and Characterization of a Micro-scale Calorimetric Flow Rate Sensor for Sweat Hydration Detection

Studying sweat and its contents can reveal important information regarding human physiology. Although sweat conductivity is a good indication for hydration status, it is known that the sweat rate affects the sweat concentration hence the conductivity. Therefore, sweat rate detection would help further assess the sweat conductivity. Here, a micro-scale calorimetric flow meter was discussed for measuring sweat flow rate that is on the order of 2µL/min ± 0. 1µL. A numerical model for the sweat flow rate sensor has been developed in MATLAB. Finite element analysis simulations were carried out using COMSOL Multiphysics. Our results showed that the sensitivity is a strong function of the distance between the heater and sensors along with the dimension of the channel. Moreover, having the sensors on platforms would increase the sensitivity of the device.
Modernizing Women's Learning in Software Development: A Study on Constructionist Pedagogy and Networked Support

We present the results of a study of the learning practices of adult women in a 10 week software engineering bootcamp in San Francisco. We explore the technical, social, and pedagogical constructionist practices resulting from student immersion in this organization. The results of our research reveal how cultivating a distributed and collocated learning process that incorporates communal support at the peer and instructional levels, while providing a network of alums and industry mentors to encourage and refine career prospects, can facilitate successful inclusion and transitioning of nontechnical women into the software engineering field.
An international survey on factors affecting self-employment intentions among students of agriculture and life sciences

In this study, we investigated the dependence of self-employment intention (SEINT) level in agricultural students from Croatia, Poland, Slovakia and Serbia on selected personal traits and country macroeconomic indicators. The results show that the SEINT level depends on student's perceived desirability of self-employment and perceived self-efficacy. Previous experience with entrepreneurship also affects SEINT. In terms of macroeconomic indicators, higher GDP per capita has been shown to have a positive effect on SEINT, while unfavorable conditions of starting a business have a negative impact. Students from Novi Sad (Serbia) showed higher average SEINT level compared to students from Croatia (Zagreb) and Slovakia (Nitra).
LISTA ACTUAL DE ANOMALÍAS MORFOLÓGICAS EN ANFIBIOS MEXICANOS, CON DOS CASOS NUEVOS EN EL CENTRO-OESTE DEL ESTADO DE VERACRUZ.

La existencia de anomalías en anfibios se ha documentado en todo el mundo. Una anomalía morfológica se define como cualquier desviación del rango normal de variación anatómica, que puede ser causada por mutaciones, fallas en el desarrollo embrionario o trauma. En México, la información científica publicada sobre anomalías morfológicas en anfibios ha sido reciente y en la mayoría se trata de casos aislados observados en campo. Aquí presentamos el primer reporte de anoftalmia en Bolitoglossa platydactyla y un caso de exceso de piel en Rheohyla miotympanum. Así como, una lista actualizada de los casos de anomalías morfológicas en anfibios mexicanos.
Simulation and measurement of threshold pump powers for the stimulated Brillouin scattering (SBS) and stimulated Raman scattering (SRS) in ytterbium-doped double-clad CW fiber amplifiers

By considering propagation equations of Stokes-waves for different orders of the stimulated Brillouin scattering (SBS) and the stimulated Raman scattering (SRS) together with propagation-rate equations of Ytterbium-doped double-clad fiber amplifiers, we numerically analyze steady-state characteristics of these amplifiers such as Amplified Spontaneous Emission (ASE) and threshold pump power and parameters which have influence over it such as pumping configuration, pumping wavelength, input signal wavelength, input signal power, input signal bandwidth and amplifier geometry. Also in an experimental setup threshold pump powers under both forward and backward pumping configurations are measured. Our results are of prime importance for applications such as nonlinear frequency generation.
Designing plasmonic structures

This thesis describes methods and results used in the design of various photonic structures. The emphasis of this thesis is in the theoretical and computational methods employed in the design. Many structures were fabricated and experimentally characterized confirming simulation results. Theoretically, surface plasmons (SPs) or more generally the study of light near microor nano-fabricated metallic surfaces, play a major role in all structures in this thesis. An effective work-flow in designing “plasmonic” structures is detailed. Various applications are then discussed: (1) Enhanced transmission through subwavelength apertures in metal films; (2) long range SP hybrid waveguides for use in the area of micro-electronics; (3) circular micro-polarizers, which also filter for a specific color band, combined with linear polarizers for full stokes polarization imaging; and (4) using plasmonic couplers to increase efficiency of metal-insulator-metal (MIM) tunnel junction detectors for use in the low THz. General conclusions about the efficacy of plasmonic structures, or the lack thereof, in these applications are discussed.
A Count Sketch Maximal Weighted Residual Kaczmarz Method with Oblique Projection for Highly Overdetermined Linear Systems

Motivated by the count sketch maximal weighted residual Kaczmarz (CSMWRK) method presented by Zhang and Li (Appl. Math. Comput., 410, 126486), we combine the count sketch tech with the maximal weighted residual Kaczmarz Method with Oblique Projection (MWRKO) constructed by Wang, Li, Bao and Liu (arXiv: 2106.13606) to develop a new method for solving highly overdetermined linear systems. The convergence rate of the new method is analyzed. Numerical results demonstrate that our method performs better in computing time compared with the CS-MWRK and MWRKO methods.
Mobile 3D laser scanning technology application in the surveying of urban underground rail transit

Mobile 3D laser scanning technology is one hot kind of digital earth technology. 3D completion surveying is relative new concept in surveying and mapping. A kind of mobile 3D laser scanning system was developed for the urban underground rail 3D completion surveying. According to the characteristics of underground rail environment and the characters of the mobile laser scanning system, it designed a suitable test scheme to improving the accuracy of this kind of mobile laser scanning system when it worked under no GPS signal environment. Then it completed the application of this technology in the No.15 rail 3D completion surveying. Meanwhile a set of production process was made for the 3D completion surveying based on this kind of mobile 3D laser scanning technology. These products were also proved the efficiency of the new technology in the rail 3D completion surveying. Using mobile 3D laser scanning technology to complete underground rail completion surveying has been the first time in China until now. It can provide a reference for 3D measurement of rail completion surveying or the 3D completion surveying of other areas.
Isolation and Optimization of Hydrocarbon – Degrading Bacteria

Aims: To isolate and characterize hydrocarbon – degraders in a contaminated soil sample Study Design: This experiment was carried out under aseptic conditions. The result was confirmed by visible spectrophotometer Place and Duration of Study: Department of Biological Sciences, Microbiology Programme, Clifford University, Ihie Campus, Owerrinta, Abia State, Nigeria, between May 2021 to July 2021 Methodology: Soil sample contaminated with hydrocarbon used in this experiment was from an automobile mechanic workshop. A ten-fold serial dilution was made for each soil sample, after which 1 ml of 10-5 dilutions was plated out using pour plate method and incubated at 37 0C for 48 hrs. The isolates were then grown on different hydrocarbons (crude oil, fuel or spent engine oil) and the degradation efficiency was confirmed by visible spectrophotometer. Result: The isolation of hydrocarbon – degrading bacteria in topsoil and subsoil samples of a mechanic workshop located in Isiala Ngwa North Local Government Area Junction, Abia State was carried out. Four bacterial species were isolated from the soil sample collected, the isolates were subjected to hydrocarbon degradation/utilization test of different hydrocarbons (crude oil, fuel or spent engine oil) it was observed that two of the isolates identified as Bacillus and Staphylococcus sp were able to utilize hydrocarbons in the medium more efficiently than other isolates. Conclusion: Hydrocarbon – degrading bacteria were isolated from an auto – mechanic workshop in Isiala Ngwa North, Abia State. Two of the four strains (Bacillus sp and Staphylococcus sp), have the highest potential to use different hydrocarbons (fuel, crude oil and condemn oil) as the sole carbon source. These strains' hydrocarbon – degrading abilities suggest that they could be effective in bioremediation of hydrocarbon – polluted locations. This could be used to combat contamination caused by motor mechanics who carelessly dispose of old motor oil in the environment, as well as general hydrocarbon contamination.
Towards a unified constructional characterisation of the nonfinite periphery

This study focuses on two extraclausal verbal constructions: free adjuncts (FAs: Not feeling at first the Pain of the Stroke, he wondered what was become of the Ball , DODDRIDGE-1747,10.72) and absolute constructions (ACs: Your Barrels being ready, strow the Bottom with Salt : DRUMMOND-1718,32.359). Adopting a quasi-synchronic approach applied to Modern and Present-Day English (PDE), we treat FAs and ACs as constructions (sufficiently frequent compositional form-meaning pairings); more specifically, we consider them two variants of a nested ‘nonfinite-periphery construction’ in which the parameter ±subject in the nonfinite periphery determines the ascription of the construction to either the FA or the AC type. In order to relate our findings to those of Rio-Rey (2002) for Early Modern English and Kortmann (1991) for PDE, we analyse more than 3,000 FAs and ACs from the Penn Parsed Corpus of Modern British English, a multi-genre parsed corpus of Late Modern English (1700–1914), and from the British component of the International Corpus of English (ICE-GB). We hypothesise that FAs and ACs deserve unitary constructional treatment in Modern and PDE, on the basis of the statistical homogeneity of their frequencies, the fixation and reduction of the set of potential introducers, the comparable proportions of FAs and ACs semantically related to the clause, their preference for sentence-final position, and the increase of the less informative types.
RESPUESTAS FISIOLÓGICAS Y MORFOLÓGICAS DE Argemone ochroleuca SWEET AL DÉFICIT HÍDRICO

En Texcoco, Estado de México, Argemone ochroleuca Sweet invade campos de cultivo durante el invierno, cuando la precipitación pluvial es escasa, por lo que se asume que esta especie posee mecanismos que le permiten tolerar condiciones limitantes de humedad en el suelo. El objetivo de esta investigación fue identificar los efectos morfológicos y fisiológicos que causa el déficit hídrico en A. ochroleuca durante la fase vegetativa. El experimento se realizó en una cámara de ambiente controlado a partir de semillas germinadas en laboratorio. Semillas con radícula visible se trasplantaron en tubos de PVC con suelo arenoso como sustrato y a los 30 días se separaron en dos grupos, para riego y déficit hídrico. Se realizaron seis muestreos espaciados a intervalos de siete días. El diseño experimental fue completamente al azar con cinco repeticiones y la unidad experimental fue cada tubo con una planta. El potencial hídrico del suelo (ΨAs) fue aproximadamente 16, la conductancia estomática (gs) 2.3, el potencial hídrico (ΨAv) del vástago 0.4 y el potencial osmótico (Ψπ ) del vástago 0.4 veces menor en el tratamiento de déficit hídrico con respecto al testigo. La concentración de azúcares y prolina aumentaron conforme el estrés hídrico avanzó. En déficit hídrico, el crecimiento del vástago de A. ochroleuca disminuyó en 10 %; sin embargo, contribuyó en la elongación y engrosamiento de la raíz principal. Se concluye que las cualidades fisiológicas y características morfológicas de Argemoneochroleuca le permiten sobrevivir en condiciones de humedad limitada y periodos de déficit hídrico prolongados.
Role of Mineralocorticoid Receptor Antagonists in Diabetic Kidney Disease

Diabetic kidney disease (DKD) represents a major public health issue, currently posing an important burden on healthcare systems. Renin–angiotensin system (RAS) blockers are considered the cornerstone of treatment of albuminuric DKD. However, a high residual risk of progression to more advanced CKD stages under RAS blockade still remains, while relevant studies did not show significant declines in cardiovascular events with these agents in patients with DKD. Among several other pharmacological classes, mineralocorticoid receptor antagonists (MRAs) have received increasing interest, due to a growing body of high-quality evidence showing that spironolactone and eplerenone can significantly lower blood pressure and albuminuria in patients with CKD. Furthermore, finerenone, a novel nonsteroidal MRA with unique physicochemical properties, was shown to effectively reduce cardiovascular events and death, as well as the incidence of end-stage kidney disease in patients with type 2 diabetes. This review discusses previous and recent clinical evidence on the issue of nephroprotection and cardioprotection in DKD offered by mineralocorticoid receptor antagonism, aiming to aid clinicians in their treatment decisions for diabetic patients.
Position controlled Knee Rehabilitation Orthotic Device for Patients after Total Knee Replacement Arthroplasty

Knee rehabilitation after total knee replacement arthroplasty is essential for patients during their post-surgery recovery period. This study is about designing one degree of freedom knee rehabilitation equipment to assist patients for their post-surgery exercise. The equipment is designed to be used in sitting position with flexion/extension of knee in sagittal plane. The range of knee joint motion is starting from 0 to 90 degrees angle for knee rehabilitation motion. The feature includes adjustable link for different human proportions and the torque feedback control at knee joint during rehabilitation and the control of flexion/extension speed. The motion of the rehabilitation equipment was set to move at low speed (18 degrees/sec) for knee rehabilitation. The rehabilitation link without additional load took one second to move from vertical hanging up to 90° while the corresponding torque increased from 0 Nm to 2 Nm at 90°. When extra load is added, the link took 1.5 seconds to move to 90° The torque is then increased from 0 Nm to 4 Nm. After a period of time, the speed of the motion can be varied. User can adjust the motion to 40 degrees/sec during recovery activity of the knee and users can increase the level of exercise or motion up to 60 degrees/sec to strengthen the muscles during throughout their rehabilitation program depends on each patient. Torque control is included to prevent injury. Patients can use the equipment for home exercise to help reduce the number of hospital visit while the patients can receive an appropriate therapy for their knee recovery program.
Relationship of Selected Physiological Variables With Playing Ability Among National Level Volleyball Players

The Purpose of the study was to find out the relationship of selected physiological variables with playing ability among national Level Volleyball Players. For this purpose Forty five(N=45) Boys Volleyball players, who had participated the mini National tournament in 2013-2014 seasons, were selected as subjects. Among the physiological parameters only Resting Pulse Rate and Respiratory Rate were selected as criterion variables. Resting pulse rate and Respiratory Rate were assessed through Manuel methods. Volleyball playing ability was assessed through subjective rating by three experts during the mini national Volleyball tournaments and the average was taken as criterion score. Person’s product moment correlation (zero order) was used as a statistical tool to find out the result and it revealed that the physiological variables of resting pulse rate and respiratory rate were having significant relationship with Volleyball performance.
Ultrawide‐Angle Ultralow‐Reflection Phenomenon for Transverse Electric Mode in Anisotropic Metasurface

The Brewster effect plays a significant role in the transmission of electromagnetic waves with a transverse magnetic mode or p‐polarization at a specific angle. Here, a transverse electric mode ultrawide‐angle ultralow‐reflection phenomenon is proposed to realize perfect transparency at ultrawide incidence angles. Theoretical formulae are derived to provide the basis for the ultrawide‐angle ultralow‐reflection phenomenon and to explain the significant characteristics of achieving an ultrawide‐angle transmission response. As a proof of concept, a metasurface with an ultrawide‐angle ultralow‐reflection response is designed and measured, whose relative permittivity and permeability tensors are tuned by engineering an electric resonator and a magnetic resonator, respectively. This study unveils a new path for the design of ultrawide‐angle transparent surfaces.
PENGARUH KONTRAK HUTANG, BIAYA POLITIK, DAN KEPEMILIKAN INSTITUSIONAL TERHADAP MANAJEMEN LABA PADA SEKTOR INDUSTRI MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA SELAMA TAHUN 2016-2018

The purpose of this research is to know the effect of leverage, political cost, and institutional ownership of earnings management on manufacturing company listed on the Indonesia Stock Exchange from 2016-2018. The sampling method used in this research used 36 manufacturing companies that were selected using purposive sampling method. Data used for this studyis obtained from financial statement for the year ended December 31st during 2016-2018. Analysis tool that will be used to analyze the hypothesis with multiple linier regression model is software Eviews 9.0. The result for this research showed that leverage have negative and not significant effect, political cost have positive and not significant effect, while institutional ownership have positive and significant effect.
Factores psicológicos asociados al riesgo suicida en estudiantes universitarios de Honduras

El riesgo suicida es definido como la posibilidad de que una persona atente deliberadamente contra su vida y se considera una conducta autodestructiva de causas multifactoriales. El propósito de esta investigación fue determinar los factores psicológicos asociados al riesgo suicida en estudiantes universitarios. Esto se realizó por medio de un enfoque cuantitativo no experimental. La muestra estuvo conformada por 1696 estudiantes de pregrado, 54.7 % correspondiente al sexo femenino y 43.6 % al masculino. Se aplicaron escalas para evaluar sentido de la vida, depresión, esperanza, soledad, apoyo interpersonal y riesgo suicida. Los resultados indicaron que el 50% de la muestra reportó nunca haber tenido pensamientos suicidas. Sin embargo, el 26.8 % tuvo un pensamiento pasajero al respecto; el 9.9 % planeó quitarse la vida, pero no lo intentó; el 5.8 % realizó un intento suicida sin intención real de concretar el acto, el 5 % hizo planes para quitarse la vida con intención real de concretar el acto; y el 2.4 % efectuó intentos suicidas con deseos de morir. Se evidenció que existe una relación inversa significativa entre el riesgo suicida y la esperanza, presencia y búsqueda de sentido de la vida y apoyo interpersonal. No obstante, los individuos con mayor riesgo suicida poseen puntajes más altos en soledad y depresión. Estos resultados se discuten desde sus implicaciones en el ejercicio clínico.