Miracle-dz/UniFAR-FTUs huggingface dataset:
Morphological and Hemodynamic Characteristics Associated With the Rupture of Multiple Intracranial Aneurysms

Background and Purpose The objective of this study was to identify the morphological and hemodynamic factors associated with the rupture of multiple intracranial aneurysms regardless of patient-related factors and establish a statistical model for aneurysm rupture risk assessment. Methods The digital subtraction angiography (DSA) data of 104 mirror intracranial aneurysms in 52 consecutive patients were retrospectively analyzed in this study. 21 morphological parameters and hemodynamic parameters were calculated by 3-dimensional reconstruction and computational fluid dynamics (CFD) simulation. Significant differences (p < 0.05) between the two groups were subsequently tested with the multivariate logistic regression to identify the independent risk factors. A prediction model was established based on the independent risk factors. The receiver operating characteristics (ROCs) were generated to estimate the prediction performance. A cohort of patients with multiple intracranial aneurysms admitted in our institute from January 2021 to October 2021 was introduced to verify the value of the model. Results Significant differences between the ruptured and unruptured aneurysms were found in 15 out of 19 parameters. Bleb formation, neck width, and size ratio were independent factors in the multivariate logistic regression. A prediction model based on the three independent risk factors was established: Odds = −1.495 – 0.707 × (Neckwidth) + 3.061 × (Blebformation) + 2.1 × (SR) (bleb formation: Yes = 1, No = 0). The area under the curve (AUC) value of the model was 0.901. In the validation cohort, the prediction model showed satisfying performance in assessing multiple aneurysm rupture risk with a sensitivity of 100% and specificity of 88.46%. Conclusion Bleb formation, neck width, and size ratio were independently associated with aneurysm rupture status. The prediction model may help in identifying the aneurysm with high rupture risk.
Association of perioperative midazolam use and complications: a population-based analysis

Introduction The benzodiazepine midazolam is the main sedative used in the perioperative setting, resulting in anxiolysis and a reduction in anesthetic dose requirements. However, benzodiazepine use is also associated with potentially serious side effects including respiratory complications, and postoperative delirium (POD). A paucity of population level data exists on current perioperative midazolam use in adult orthopedic surgery and its effects on complications. Using a large national dataset, we aimed to determine perioperative midazolam utilization patterns and to analyze its effect on postoperative outcomes. Methods Patients who underwent total knee and hip arthroplasty (TKA/THA) were identified from Premier database (2006–2019). Primary exposure of interest was midazolam use on the day of surgery. Multivariable logistic regression models were run to determine if midazolam was associated with postoperative cardiac and pulmonary complications, delirium, and in-hospital falls. Results Among 2,848,897 patients, more than 75% received midazolam perioperatively. This was associated with increased adjusted odds for in-hospital falls in TKA/THA (OR 1.1, 95% CI 1.07 to 1.14)/(OR 1.1, 95% CI 1.06 to 1.16), while a decrease in the adjusted odds for cardiac complications in TKA/THA (OR 0.94, 95% CI 0.91 to 0.97)/(OR 0.93, 95% CI 0.89 to 0.97), and pulmonary complications (OR 0.92, 95% CI 0.87 to 0.96) (all p<0.001) was seen. Most notably, the concurrent use of midazolam and gabapentinoids significantly increased the adjusted odds for postoperative complications, including pulmonary complications (OR 1.22, 95% CI 1.18 to 1.27)/(OR 1.29, 95% CI 1.22 to 1.37), naloxone utilization (OR 1.56, 95% CI 1.51 to 1.60)/(OR 1.49, 95% CI 1.42 to 1.56), and POD (OR 1.45, 95% CI 1.38 to 1.52)/(OR 1.32, 95% CI 1.23 to 1.34) in THA/TKA. Conclusion Perioperative midazolam use was associated with an increase in postoperative patient falls, and a decrease in cardiac complications. Notably, the combined use of midazolam and gabapentinoids was associated with a substantial increase in the odds for respiratory failure and delirium. Given the high prevalence of benzodiazepines perioperatively, the risk benefit profile should be more clearly established to inform perioperative decision making.
Guideline model for the bias-scheme-dependent power consumption of a resistive random access memory crossbar array

The 1/2 and 1/3 bias schemes are commonly used to select a cell in a resistive random access memory (ReRAM) crossbar array. The 1/3 bias scheme is advantageous in terms of its write margin but typically requires a higher power consumption than the 1/2 bias scheme. The power consumption of ReRAM can vary according to the nonlinearity of the selector device. In this paper, we propose a power guideline model that suggests selector nonlinearity requirements to guarantee a lower power consumption for the 1/3 bias scheme than for the 1/2 bias scheme. Therefore, the selector nonlinearity requirements for the low power consumption of the 1/3 bias scheme can be immediately obtained using this guideline model without simulation.
Kangbainian Lotion Ameliorates Vulvovaginal Candidiasis in Mice by Inhibiting the Growth of Fluconazole-Resistant Candida albicans and the Dectin-1 Signaling Pathway Activation

Vulvovaginal candidiasis (VVC) is an infectious disease caused by Candida species, which affects millions of women worldwide every year. The resistance to available antifungal drugs for clinical treatment is a growing problem. The treatment of refractory VVC caused by azole-resistant Candida is still facing challenges. However, research on new antifungal drugs is progressing slowly. Although a lot of reports on new antifungal drugs, only three new antifungal drugs (Isavuconazole, ibrexafungerp, and rezafungin) and two new formulations of posaconazole were marketed over the last decade. Chinese botanical medicine has advantages in the treatment of drug-resistant VVC, such as outstanding curative effects and low adverse reactions, which can improve patients’ comfort and adherence to therapy. Kangbainian lotion (KBN), a Chinese botanical formulation, has achieved very good clinical effects in the treatment of VVC. In this study, we investigated the antifungal and anti-inflammatory effects of KBN at different doses in fluconazole-resistant (FLC-resistant) VVC model mice. We further studied the antifungal mechanism of KBN against FLC-resistant Candida albicans (C. albicans) and the anti-inflammatory mechanism correlated with the Dectin-1 signaling pathway. In vivo and in vitro results showed that KBN had strong antifungal and anti-inflammatory effects in FLC-resistant VVC, such as inhibiting the growth of C. albicans and vaginal inflammation. Further studies showed that KBN inhibited the biofilm and hypha formation, reduced adhesion, inhibited ergosterol synthesis and the expression of ergosterol synthesis-related genes ERG11, and reduced the expression of drug-resistant efflux pump genes MDR1 and CDR2 of FLC-resistant C. albicans in vitro. In addition, in vivo results showed that KBN reduced the expression of inflammatory factor proteins TNF-α, IL-1β, and IL-6 in vaginal tissues, and inhibited the expression of proteins related to the Dectin-1 signaling pathway. In conclusion, our study revealed that KBN could ameliorate vaginal inflammation in VVC mice caused by FLC-resistance C. albicans. This effect may be related to inhibiting the growth of FLC-resistance C. albicans and dectin-1 signaling pathway activation.
Gas-Phase Reactivity of OH Radicals With Ammonia (NH3) and Methylamine (CH3NH2) at Around 22 K

Interstellar molecules containing N atoms, such as ammonia (NH3) and methylamine (CH3NH2), could be potential precursors of amino acids like the simplest one, glycine (NH2CH2COOH). The gas-phase reactivity of these N-bearing species with OH radicals, ubiquitous in the interstellar medium, is not known at temperatures of cold dark molecular clouds. In this work, we present the first kinetic study of these OH-reactions at around 22 K and different gas densities [(3.4–16.7) × 1016 cm−3] in helium. The obtained rate coefficients, with ± 2σ uncertainties, can be included in pure gas-phase or gas-grain astrochemical models to interpret the observed abundances of NH3 and CH3NH2. We observed an increase of k 1 and k 2 with respect to those previously measured by others at the lowest temperatures for which rate coefficients are presently available: 230 and 299 K, respectively. This increase is about 380 times for NH3 and 20 times for CH3NH2. Although the OH + NH3 reaction is included in astrochemical kinetic databases, the recommended temperature dependence for k 1 is based on kinetic studies at temperatures above 200 K. However, the OH + CH3NH2 reaction is not included in astrochemical networks. The observed increase in k 1 at ca. 22 K does not significantly change the abundance of NH3 in a typical cold dark interstellar cloud. However, the inclusion of k 2 at ca. 22 K, not considered in astrochemical networks, indicates that the contribution of this destruction route for CH3NH2 is not negligible, accounting for 1/3 of the assumed main depletion route (reaction with HCO+) in this IS environment. k 1 ( OH+N H 3 ) = ( 2.7 ± 0.1 ) × 10 − 11 c m 3 s -1 k 2 ( OH+C H 3 N H 2 ) = ( 3.9 ± 0.1 ) × 10 − 10 c m 3 s -1
Efficacy of Aspergillus sp in the Production of Protease Enzyme with Different Substrates

In the present study, the soil samples were collected from marine environment of Arichalmunai, Dhanushkodi, Ramnad District, Tamilnadu ,India. Fungal species were isolated by plating method, in 50% sea water containing potato dextrose agar medium . Totally 16 fungal species were isolated and identified from the soil sample. The production of protease from Aspergillus niger , A.flavus and A. terreus by liquid state fermentation. The production of protease enzyme was optimized by using fermentation medium containing different substrates. The maximum protease production was observed on wheat bran, containing medium. The protease production was maximum in temperature 35 o C were recorded. Wheat bran produced the maximum level protease. The optimization work also carried out. This study revealed that coastal environment provides impressive density of fungi in the East Coast of India and are unexplored for microbial resources can be useful in industry.
Picture-Word Interference Effects Are Robust With Covert Retrieval, With and Without Gamification

The picture-word interference (PWI) paradigm has been used to investigate the time course of processes involved in word retrieval, but is challenging to implement online due to dependence on measurements of vocal reaction time. We performed a series of four experiments to examine picture-word interference and facilitation effects in a form of covert picture naming, with and without gamification. A target picture was accompanied by an audio word distractor that was either unrelated, phonologically-related, associatively-related, or categorically-related to the picture. Participants were instructed to judge whether the name of the target picture ended in the phoneme assigned to the block by pressing corresponding keys as quickly and accurately as possible. Experiments 1 and 2 successfully replicated categorical interference and phonological facilitation effects at different optimal stimulus-onset-asynchronies (SOAs) between words and pictures. Experiment 3 demonstrated that a key gamification feature (collecting coins) motivated faster speed at the expense of accuracy in the gamified vs. experimental format of the task. Experiment 4 adopted the optimal SOAs and verified that the gamification reveals expected interference and facilitation effects despite the speed-accuracy tradeoff. These studies confirmed that categorical interference occurs earlier than phonological facilitation, while both processes are independent from articulation and inherent to word retrieval itself. The covert PWI paradigm and its gamification have methodological value for neuroimaging studies in which articulatory artifacts obscure word retrieval processes, and may be developed into potential online word-finding assessments that can reveal word retrieval difficulties with greater sensitivity.
Systems Pharmacology Modeling Identifies a Novel Treatment Strategy for Bortezomib-Induced Neuropathic Pain

Chemotherapy-induced peripheral neurotoxicity is a common dose-limiting side effect of several cancer chemotherapeutic agents, and no effective therapies exist. Here we constructed a systems pharmacology model of intracellular signaling in peripheral neurons to identify novel drug targets for preventing peripheral neuropathy associated with proteasome inhibitors. Model predictions suggested the combinatorial inhibition of TNFα, NMDA receptors, and reactive oxygen species should prevent proteasome inhibitor-induced neuronal apoptosis. Dexanabinol, an inhibitor of all three targets, partially restored bortezomib-induced reduction of proximal action potential amplitude and distal nerve conduction velocity in vitro and prevented bortezomib-induced mechanical allodynia and thermal hyperalgesia in rats, including a partial recovery of intraepidermal nerve fiber density. Dexanabinol failed to restore bortezomib-induced decreases in electrophysiological endpoints in rats, and it did not compromise bortezomib anti-cancer effects in U266 multiple myeloma cells and a murine xenograft model. Owing to its favorable safety profile in humans and preclinical efficacy, dexanabinol might represent a treatment option for bortezomib-induced neuropathic pain.
Efficient algorithms, architectures and implementations in internet of things and smart environments

More than just a vision, ubiquitous computing is applied in many fields of Computer Science and it has well been established. However, there are aspects which still need to be optimized and necessitate a more in-depth research to exploit even further the potential of ubiquitous computing. In this thesis we tackle problems and challenges of the ubiquitous computing in the domains of Wireless Sensor Networks (WSN), Internet of Things (IoT) and Smart Environments. Specifically, Part I contains an introduction to WSN, IoT and Smart Environments. Part II presents and evaluates two design approaches for WSN, a framework for creating personalized Smart Environments using WSN and an Airborne WSN for air pollution monitoring. Part III focuses on Crowdsourcing motivators and a Crowdsourced-enabled platform architecture. Part IV investigates Crowdsensing and Incentive Mechanisms while Part V proposes traversal strategies for Wireless Power Transfer in Mobile-Ad Hoc Networks. Part VI presents the conclusions of this thesis.
Factors Affecting Fatigue in Older Adults Receiving Home-Based Healthcare

Background. Both fatigue and depression are common health pro blems in ageing. Aim . To explore the effect of depressive symptomatolog y n the presence of fatigue in home-care patients aged 65 years old and over. Methodology. A cross-sectional study was conducted on three "H elp at Home" programs in the region of Crete, Greece. The sample consisted of 300 beneficiaries’ elders. Depressive symptomatology was assessed usin g the Greek version of the BECK Depression Inventory scal e (BECK DI) and the presence of fatigue was assesse d by the Modified Fatigue Impact Scale (MFIS). Results. The majority of the participants were female (55. 3%), mean age was 78.3 ± 7.4 years, 43% were aged >80 years old and 11.3% were bedridden. Fatigue incidence (MFIS score>46) was 58.7%. Depression was significantly associated with higher rates of fatig ue (betas=0.687, p<0.001). Also, fatigue was respec tively increased as the number of chronic diseases increas ed (p =0.031). Conclusions. Depression is independently associated with fatig ue and thus health professionals caring for older people should be suspected of the presence of depre ssion whether fatigue is expressed as a complaint.
Searching for non-aggressive targets

Faced with the possibility of losing their position due to domestic opposition, political leaders may sometimes consider initiating a foreign conflict as a means to redirect attention away from domestic issues. In such instances, which states are most likely to become diversionary targets? This study assumes that unpopular leaders prefer small-scale conflicts that can create rally-round-the-flag effects without triggering substantial domestic opposition to the use of military force abroad. Based on this assumption, hypotheses are developed which predict that states under constraint (i.e. states with democratic institutions or showing high trade openness) tend to attract diversionary-motivated actions, while states likely to reciprocate harshly (i.e. states experiencing their own domestic troubles or in relative decline) are less likely to become diversionary targets. Logit analyses of directed dyad-years from 1960 to 2001 and illustrations of marginal effects provide strong support for three of the four hypotheses – namely, that democracies and trading states are more likely, and that declining powers are less likely to be targets of diversionary actions. This study’s findings show that not all potential targets are equally attractive for diversionary actions, and that a state’s democratization, economic openness, and power growth can worsen, rather than improve, its security.
On the Design Of Manually aDjustable ankle units fOr Variable terrain: a teChniCal nOte

This article provides details on the design of adjustable ankle units for transfemoral and transtibial prosthetic devices. The design was intended to enable the user to quickly adjust the flexion of a prosthetic foot in subfreezing temperatures, where donning and doffing clothing and the prosthesis present a significant obstacle. The units must also be able to tolerate significant abuse, cold, ice, and water while maintaining their function. Additionally, the units must be attached using standard pylons or fittings and must be short enough to fit in the existing pylon space so no modification to the user’s socket or prosthetic foot is required. This article presents two potential solutions to the proposed problem, one with continuous adjustment using a friction fitting and one with discrete positioning using a geared coupling. A finite element analysis of the design was performed to determine the suitability of the design material and dimensions. The proposed friction fitting was found to have greater potential, but benefits of other methods are discussed as well. Future work will focus on failure testing of prototype devices, followed by in-use field testing by highly active amputee subjects.
Fouling control using air bubble curtains: protection for stationary vessels

There is an increasing need by the marine industries for effective non-toxic control of fouling. One of the major limitations of new fouling release coatings is that they cannot protect structures whilst stationary and will not release certain fouling organisms when vessels are operating at low speeds. This is a major problem for slow or infrequently moving vessels and for vessels docked in tropical waters where fouling pressure is extreme. This paper describes novel technology (provisional patent # 2008905482) to protect vessels whilst stationary using air bubble curtains. The results of several panel tests and one hull patch trial demonstrate that this technique is a simple, cost-effective means to complement fouling release coatings whilst vessels are in dock
The Tangled Bank

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One-dimensional Brownian motion and the three-dimensional Bessel process

(the sample path of this process is obtained from the sample path of the original Brownian motion by reflecting this path at each time point in the level of its previous maximum): the process {C(t), t ~ O} is a three-dimensional Bessel process (BESO(3)), which is to say that {C(t), t ~ O} has the same distribution as the radial part of a three-dimensional Brownian motion started at the origin. Put another way, if {C*(t), t ~ O} is a BESO(3) process, with future minimum process {D*(t), t ~ O} defined by
Peel-Off Mask from Ethanol Extract of Purple Sweet Potato Peel (Ipomoea batatas L.) for Blackhead Treatment

Acne vulgaris or acne, also known as acne, is a chronic obstructive and inflammatory skin disease in the pilosebasea unit that often occurs in adolescence. The prevalence of acne in adolescence is quite high, ranges between 47-90%. Acne mostly occurs on the face, characterized by the presence of inflammatory lesions and non-inflammatory lesions, namely blackheads. Blackheads can be in the form of open blackheads that occur due to melanin oxidation, or closed blackheads (whitehead comedones). Skin from purple sweet potato (Ipomoea batatas L.) has been reported to have antioxidants activity and have the ability to against free radicals from pollution and UV radiation from carotenoid compounds. Carotenoids are one of the compounds that can eliminate the appearance of blackheads from the skin of the face. Currently, treatment with chemicals is the first choice. However, the innovation for this product is needed. Treatment based on natural ingredients and formed as cosmetic products can be an alternative to treat facial skin and prevent blackheads from occurring puberty in adolescents. Mask is one of the facial care products that are loved by adolescents and becoming a trend nowadays. The advantages of this form are easy to use and relatively cheap, made this is the main choice for adolescents. A practice and suitable mask product are needed for adolescents, so a peel-off mask is a good choice for it.
Improved variable speed control of series-connected DC wind turbines for offshore wind power collection to high-voltage direct current system

DC wind farm (DCWF) with series-connected DC wind turbines (DCWTs) is proved to be a potential solution of offshore wind power collection. The coupling behaviour of series-connected DCWTs is described in detail. Possible wind energy curtailment during the period of wind turbine voltage limitation and its key impact factors are firstly quantitatively derived. A novel variable speed control strategy is proposed under voltage limiting condition of the DCWT to improve its wind energy capture. This control algorithm can be implemented in the local DCWT controller without the communication need. The specific variable speed control strategy of the DCWT is realised in a generalised averaged model. Dynamic simulation cases under different operation conditions have been conducted to evaluate the effectiveness of the proposed control strategy. It is found that the proposed control strategy might be a solution for wind energy curtailment, which will significantly improve the performance of the series-connected DCWTs between the time scale above seconds and below minutes.