Miracle-dz/UniFAR-FTUs huggingface dataset:
Examination of Clusters for Better Understanding Commuter Cyclists’ Travel Behavior: Insights from a Longitudinal Panel Survey

This study examined commuter cyclists’ travel behavior, particularly in response to changes in weather conditions and situational factors. The motivators, deterrents, and preferences of commuter cycling were also examined. To reach greater understanding of commuter cyclists’ decision making, cyclists were clustered. Disaggregated travel data were collected from a longitudinal panel survey (sample size: 355) and analyzed to identify the influence of weather conditions and situational factors on commuters’ day-to-day cycling decisions. The baseline survey (a one-off survey) provided information about the work characteristics, travel characteristics, motivational factors, and sociodemographics of the participants. Generalized estimating equations were used to compare the responses between groups on the day-to-day influences of weather conditions and situational factors. Binary logistic regression was used to predict commuters’ cycling decisions (whether or not to cycle). Commuter cyclists’ average decision (over the longitudinal survey period) was modeled with work characteristics, travel characteristics, motivational factors, and sociodemographics as explanatory variables. The results indicate that parameter estimates vary significantly between groups. Part-time commuter cyclists and commuter cyclists who do not plan their travel behavior in advance were more affected by adverse weather conditions than were the comparison groups. Situational factors were larger deterrents for part-time commuter cyclists and cyclists who traveled longer distances to work. However, off-road paths encouraged long-distance commuters to cycle more often. The paper includes a discussion on how the implications of these results can influence government policies and strategies in an effort to increase commuter cycling.
Decoupling climate-policy objectives and mechanisms to reduce fragmentation

ABSTRACT The efficacy of climate-change mitigation policy within the building sector is examined in terms of how fragmentation can limit the extent of mitigation actions that can be achieved in a timely manner. The policy and regulatory context for the building industry is examined in relation to the policy context for solutions and recommendations that will work for all parties. Based on this analysis, two substantive recommendations are made for improved policy design. Firstly, a decoupling of policy objectives and policy mechanisms is needed so that the policy-taking stakeholders (in design, development and construction) can reduce energy use in buildings more effectively. Secondly, policy-taking stakeholders need an explicit and diverse system in order to advocate for policy objectives. The major aspect of this work is the development of a new conceptual framework that ties together these recommendations into a continuous process of policy-making and policy-taking. This framework demonstrates an idealized system that operates simultaneously top down and bottom up, and the development of policy objectives is influenced by stakeholders of all kinds to further the goals of an energy-efficient, low-carbon built environment.
of Leeds, Sheffield and York

This experimental paper explains foreign acquisitions by Indian multinational enterprises by reference to location specific factors in both the source country (India) and host countries together with variables required designed to capture the distance between India and the host country, both geographic and psychic. The paper finds that country specific advantages play an important role in explaining Indian foreign acquisitions. The general model performs well and Indian institutional and domestic capital variables add explanatory value.
Clinical guideline utilization in Uganda: A scoping review and comparison

Countries such as Uganda often depend on clinical practice guidelines from developed countries, non-profit charities, and international organizations. The sources and organizations that provide most of the guidelines used in Uganda are not well documented. The primary objective of this article was to determine whether a scoping review of scientific, peer-reviewed literature could identify the clinical guidelines actually used in Uganda. A secondary objective was to examine which organizations provided the majority of guidelines used. We therefore searched for consensus documents, guidelines, and meta-analyses published for use in African countries indexed in PubMed, OVID Medline, and Embase, and then surveyed guidelines currently in use in Ugandan medical practice. We thus compared these two sets of guidelines, as well as their breadth, geography, and sources, to make recommendations for similar low-income countries.
Physioxia-induced downregulation of Tet2 in hematopoietic stem cells contributes to enhanced self-renewal

Aljoufi et al examined the mechanistic basis for the negative impact of ambient air on hematopoietic stem cell (HSC) self-renewal when compared to physioxia. RNA profiling delineated a role for Tet2, which is upregulated in ambient air, leading to downregulation of self-renewal genes. Loss of Tet2 rescues HSCs from sensitivity to changes in oxygen tension, suggesting a novel molecular program that may be exploited to improve ex vivo HSC expansion.
Cortical-Subcortical Interactions in Goal-directed Behavior.

Flexibly selecting appropriate actions in response to complex, ever-changing environments requires both cortical and subcortical regions, which are typically described as participating in a strict hierarchy. In this traditional view, highly specialized subcortical circuits allow for efficient responses to salient stimuli, at the cost of adaptability and context-specificity, which are attributed to the neocortex. Their interactions are often described as the cortex providing top-down command signals for subcortical structures to implement; however, as available technologies develop, studies increasingly demonstrate that behavior is represented by brain-wide activity and that even subcortical structures contain early signals of choice, suggesting that behavioral functions emerge as a result of different regions interacting as truly collaborative networks. In this review, we discuss the field's evolving understanding of how cortical and subcortical regions in placental mammals interact cooperatively- not only via top-down cortical-subcortical inputs, but through bottom-up interactions, especially via the thalamus. We describe our current understanding of the circuitry of both the cortex and two exemplar subcortical structures- the superior colliculus and striatum- to identify which information is prioritized by which regions. We then describe the functional circuits these regions form with one another- and the thalamus- to create parallel loops and complex networks for brain-wide information flow. Finally, we challenge the classic view that functional modules are contained within specific brain regions; instead, we propose that certain regions prioritize specific types of information over others, but the subnetworks they form- defined by their anatomical connections and functional dynamics- are the basis of true specialization.
Mitochondrial dysfunction in cell senescence and aging

Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely interconnected. Mitochondrial dysfunction, operationally defined as a decreased respiratory capacity per mitochondrion together with a decreased mitochondrial membrane potential, typically accompanied by increased production of oxygen free radicals, is a cause and a consequence of cellular senescence and figures prominently in multiple feedback loops that induce and maintain the senescent phenotype. Here, we summarize pathways that cause mitochondrial dysfunction in senescence and aging and discuss the major consequences of mitochondrial dysfunction and how these consequences contribute to senescence and aging. We also highlight the potential of senescence-associated mitochondrial dysfunction as an antiaging and antisenescence intervention target, proposing the combination of multiple interventions converging onto mitochondrial dysfunction as novel, potent senolytics.
Abnormal growth and morphogenesis of placenta at term is linked to adverse fetal development after perigestational alcohol consumption up to early gestation in mouse

Gestation alcohol consumption produces fetal growth restriction and malformations by affecting the embryo–fetal development. Recently a relationship between abnormal placentation and fetal malformation and intrauterine growth retardation has been suggested. However, the effects of perigestational alcohol ingestion up to early pregnancy on the placenta at term and its association with fetal abnormalities are little known.
Leveraging Algorithms to Improve Decision-Making Workflows for Genomic Data Access and Management

Studies on the ethics of automating clinical or research decision making using artificial intelligence and other algorithmic tools abound. Less attention has been paid, however, to the scope for, and ethics of, automating decision making within regulatory apparatuses governing the access, use, and exchange of data involving humans for research. In this article, we map how the binary logic flows and real-time capabilities of automated decision support (ADS) systems may be leveraged to accelerate one rate-limiting step in scientific discovery: data access management. We contend that improved auditability, consistency, and efficiency of the data access request process using ADS systems have the potential to yield fairer outcomes in requests for data largely sourced from biospecimens and biobanked samples. This procedural justice rationale reinforces a broader set of participant and data subject rights that data access committees (DACs) indirectly protect. DACs protect the rights of citizens to benefit from science by bringing researchers closer to the data they need to advance that science. DACs also protect the informational dignities of individuals and communities by ensuring the data being accessed are used in ways consistent with participant values. We discuss the development of the Global Alliance for Genomics and Health Data Use Ontology standard as a test case of ADS for genomic data access management specifically, and we synthesize relevant ethical, legal, and social challenges to its implementation in practice. We conclude with an agenda of future research needed to thoughtfully advance strategies for computational governance that endeavor to instill public trust in, and maximize the scientific value of, health-related human data across data types, environments, and user communities.
Psychiatric disorders in adult and paediatric patients with inflammatory bowel diseases - a systematic review and meta-analysis.

BACKGROUND Inflammatory bowel diseases (IBD), which are associated with a high disease burden, are also reported to be accompanied by a high prevalence of psychiatric disorders. However, the literature on IBD and psychiatric disorders has not been reviewed. METHODS This systematic review followed the PRISMA guidelines, and its protocol was registered at PROSPERO (ID: CRD42020214359). PubMed, Embase and PsycINFO were consulted for the literature search. Studies reporting on diagnosed psychiatric disorders in IBD were included. Pooled prevalence rates were calculated using random effects meta-analyses. Study quality was assessed using the Newcastle-Ottawa Scale (NOS). RESULTS Sixty-nine studies were identified with an average cohort size of 60,114 patients. Pooled prevalence rates were: mood disorders, 10% (95% CI=7%; 15%); anxiety disorders, 12% (95% CI=8%; 18%); substance misuse, 3% (95% CI=1%; 7%); psychotic disorders, 2% (95% CI=1%; 4%); behavioral disorders, 1% (95% CI=0%; 3%); personality disorders, 3% (95% CI=1%; 10%); developmental disorders, 1% (95% CI=0%; 3%); behavioral and emotional disorders with onset usually during childhood, 1% (95% CI=1%; 3%). All analyses had high statistical heterogeneity (I2 > 99%). Seven studies reported an increased risk of suicide in IBD patients compared to controls. CONCLUSION The prevalence of psychiatric comorbidities was high (11- 82%) in patients with IBD and was higher than in the background population. Addressing mental health problems in patients with IBD can improve their adherence to treatment and the somatic disease course and, consequently, reduce morbidity and mortality.
The role of microbiome: a novel insight into urolithiasis

Abstract Urolithiasis, referred to as the formation of stones in the urinary tract, is a common disease with growing prevalence and high recurrence rate worldwide. Although researchers have endeavoured to explore the mechanism of urinary stone formation for novel effective therapeutic and preventative measures, the exact aetiology and pathogenesis remain unclear. Propelled by sequencing technologies and culturomics, great advances have been made in understanding the pivotal contribution of the human microbiome to urolithiasis. Indeed, there are diverse and abundant microbes interacting with the host in the urinary tract, overturning the dogma that urinary system, and urine are sterile. The urinary microbiome of stone formers was clearly distinct from healthy individuals. Besides, dysbiosis of the intestinal microbiome appears to be involved in stone formation through the gut-kidney axis. Thus, the human microbiome has potential significant implications for the aetiology of urolithiasis, providing a novel insight into diagnostic, therapeutic, and prognostic strategies. Herein, we review and summarize the landmark microbiome studies in urolithiasis and identify therapeutic implications, challenges, and future perspectives in this rapidly evolving field. To conclude, a new front has opened with the evidence for a microbial role in stone formation, offering potential applications in the prevention, and treatment of urolithiasis.
Contribution of B cells to cortical damage in multiple sclerosis.

Multiple sclerosis is associated with lesions not just in the white matter, but also involving the cortex. Cortical involvement has been linked to greater disease severity and hence understanding the factor underlying cortical pathology could help identify new therapeutic strategies for multiple sclerosis. The critical role of B cells in multiple sclerosis has been clarified by multiple pivotal trials of B cell depletion in people with multiple sclerosis. The presence of B cell rich areas of meningeal inflammation in multiple sclerosis has been identified at all stages of multiple sclerosis. Leptomeningeal inflammation is associated with greater extent of cortical demyelination and neuronal loss and with greater disease severity. Recent studies have identified several potential mechanisms by which B cells may mediate cortical injury including antibody production, extracellular vesicles containing neurotoxic substances and production of pro-inflammatory cytokines. Additionally, B cells may indirectly mediate cortical damage through effects on T cells, macrophages or microglia. Several animal models replicate the meningeal inflammation and cortical injury noted in people with multiple sclerosis. Studies in these models have identified BTK inhibition and type II anti-CD20 antibodies as potential agents that can impact meningeal inflammation. Trials of anti-CD20 monoclonal antibodies in people with multiple sclerosis have unsuccessfully attempted to eliminate B cells in the leptomeninges. New strategies to target B cells in multiple sclerosis include BTK inhibition and cell-based therapies aimed at B cells infected with Epstein Barr virus. Future studies will clarify the mechanisms by which B cells mediate cortical injury and treatment strategies that can target B cells in the leptomeninges and CNS parenchyma.
Adverse drug reactions following lymphocyte immunotherapy for the treatment of infertility: A retrospective study

Unexplained infertility is a major burden for couples who want to have children. Lymphocyte immunotherapy (LIT) could be a therapeutic help for these couples. Although LIT has been carried out for decades, the data on the success of therapy are still controversial and there is hardly information on possible adverse drug reactions.
Investigating software developers' understanding of open source software licensing

Software provided under open source licenses is widely used, from forming highprofile stand-alone applications (e.g., Mozilla Firefox) to being embedded in commercial offerings (e.g., network routers). Despite the high frequency of use of open source licenses, there has been little work about whether software developers understand the open source licenses they use. To help understand whether or not developers understand the open source licenses they use, I conducted a survey that posed development scenarios involving three popular open source licenses (GNU GPL 3.0, GNU LGPL 3.0 and MPL 2.0) both alone and in combination. The 375 respondents to the survey, who were largely developers, gave answers consistent with those of a legal expert’s opinion in 62% of 42 cases. Although developers clearly understood cases involving one license, they struggled when multiple licenses were involved. To understand the context in which licensing issues arise in practice, I analyzed real-world questions posed by developers on online questionand-answer communities. The analysis of these questions indicate that licensing issues can constrain software evolution and technical decisions can have an impact on future licensing issues. Finally, I interviewed software developers in industry to understand how developers reason about and handle license incompatibility in practice. The developers I interviewed are cautious of restrictive licenses. To identify potential licensing issues, these developers rely on licensing guidelines provided by their organization and sometimes use specialized tools to automatically detect licensing issues in their projects. When faced with a situation in which a component that suits their needs is not compatible, developers tend to look for alternative components made available by open source communities. They sometimes leverage the technical architecture of their projects to enable the use of com-
Neuroprotective effects of visnagin on cerebral ischemia-reperfusion injury rats and the underlying mechanisms.

OBJECTIVE Cerebral ischemia-reperfusion (I/R), caused by the treatments of ischemic stroke, usually leads to brain injury. Inflammation, oxidative stress, and autophagy play pivotal roles in the pathology. Visnagin presents a protective effect on I/R injured animal models of the heart, liver, kidney, and other organs. In our research, we identified the neuroprotective effects and the underlying mechanisms of visnagin in cerebral I/R injured models. MATERIALS AND METHODS We constructed rat models of cerebral I/R injury and categorized them into 5 groups: sham operation group, I/R model group, and visnagin treatment I/R group (10, 30, 60 mg/kg). The neurological deficits of the rats were analyzed after 24 hours of reperfusion, then, the contents of glutathione peroxidase, malondialdehyde, superoxide dismutase catalase, caspase-3, nuclear factor kappa-B p65 unit, tumor necrosis factor-α, interleukin-1β, and interleukin6 were measured in rat models. The expressions of Bcl-2 and Bax were detected by Western blot analysis. RESULTS Our results suggested that the administration of visnagin alleviated the cognitive dysfunction, reduced the activities of inflammatory factors, promoted the protein expression of Bcl-2, and downregulated the expression of Bax in the I/R injured rat model. CONCLUSIONS Visnagin exerts a neuroprotective effect during I/R injury in rats, the underlying mechanisms may be the effect of attenuating neuroinflammation, anti-oxidative and inhibition of apoptosis.
Accumulation of advanced oxidation protein products contributes to age-related impairment of gap junction intercellular communication in osteocytes of male mice

Aims Gap junction intercellular communication (GJIC) in osteocytes is impaired by oxidative stress, which is associated with age-related bone loss. Ageing is accompanied by the accumulation of advanced oxidation protein products (AOPPs). However, it is still unknown whether AOPP accumulation is involved in the impairment of osteocytes’ GJIC. This study aims to investigate the effect of AOPP accumulation on osteocytes’ GJIC in aged male mice and its mechanism. Methods Changes in AOPP levels, expression of connexin43 (Cx43), osteocyte network, and bone mass were detected in 18-month-old and three-month-old male mice. Cx43 expression, GJIC function, mitochondria membrane potential, reactive oxygen species (ROS) levels, and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation were detected in murine osteocyte-like cells (MLOY4 cells) treated with AOPPs. The Cx43 expression, osteocyte network, bone mass, and mechanical properties were detected in three-month-old mice treated with AOPPs for 12 weeks. Results The AOPP levels were increased in aged mice and correlated with degeneration of osteocyte network, loss of bone mass, and decreased Cx43 expression. AOPP intervention induced NADPH oxidase activation and mitochondrial dysfunction, triggered ROS generation, reduced Cx43 expression, and ultimately impaired osteocytes’ GJIC, which were ameliorated by NADPH oxidase inhibitor apocynin, mitochondria-targeted superoxide dismutase mimetic (mito-TEMPO), and ROS scavenger N-acetyl cysteine. Chronic AOPP loading accelerated the degradation of osteocyte networks and decreased Cx43 expression, resulting in deterioration of bone mass and mechanical properties in vivo. Conclusion Our study suggests that AOPP accumulation contributes to age-related impairment of GJIC in osteocytes of male mice, which may be part of the pathogenic mechanism responsible for bone loss during ageing. Cite this article: Bone Joint Res 2022;11(7):413–425.
Therapeutic effect of the mesenchymal stem cells on vigabatrin-induced retinopathy in adult male albino rat

Vigabatrin (VGB) is an effective antiepileptic drug used mainly to treat infantile spasms and refractory complex partial seizures. However, using VGB was restricted as it was known to cause retinal toxicity that appears as a severe peripheral visual field defect. Accordingly, this study was conducted to examine the histopathological and biochemical effects of VGB on the retina in adult male albino rats and assess the possible therapeutic role of mesenchymal stem cells (MSCs) against this potential toxicity. The rats were divided into three groups (control group, VGB group, and VGB/MSCs group), one week after 65 days of VGB treatment ±MSCs. The right eyeballs were prepared for histological and immunohistochemical examination, whereas the left eyeballs were prepared for real-time polymerase chain reaction analysis. Our results demonstrated that MSCs ameliorated retinal pathological changes and downregulated the expression of glial fibrillary acidic protein, vascular endothelial growth factor, and synaptophysin after VGB administration suggesting MSCs function and vascular modulating effect. Moreover, MSCs regulate retinal tissue gene expression of BAX, Bcl-2, BDNF, NGF, synapsin, interleukin (IL)-6, IL-1β, and occludin suggesting MSCs antiapoptotic and immunomodulating effect. In conclusion, MSCs administration could be a suitable therapeutic line to ameliorate VGB-induced retinopathy.