Miracle-dz/UniFAR-FTUs huggingface dataset:
A Remote Longitudinal Observational Study of Individuals at Genetic Risk for Parkinson Disease

Background and Objectives To recruit and characterize a national cohort of individuals who have a genetic variant (LRRK2 G2019S) that increases risk of Parkinson disease (PD), assess participant satisfaction with a decentralized, remote research model, and evaluate interest in future clinical trials. Methods In partnership with 23andMe, Inc., a personal genetics company, LRRK2 G2019S carriers with and without PD were recruited to participate in an ongoing 36-month decentralized, remote natural history study. We examined concordance between self-reported and clinician-determined PD diagnosis. We applied the Movement Disorder Society Prodromal Parkinson's Disease Criteria and asked investigators to identify concern for parkinsonism to distinguish participants with probable prodromal PD. We compared baseline characteristics of LRRK2 G2019S carriers with PD, with prodromal PD, and without PD. Results Over 15 months, we enrolled 277 LRRK2 G2019S carriers from 34 states. At baseline, 60 had self-reported PD (mean [SD] age 67.8 years [8.4], 98% White, 52% female, 80% Ashkenazi Jewish, and 67% with a family history of PD), and 217 did not (mean [SD] age 53.7 years [15.1], 95% White, 59% female, 73% Ashkenazi Jewish, and 57% with a family history of PD). Agreement between self-reported and clinician-determined PD status was excellent (κ = 0.94, 95% confidence interval 0.89–0.99). Twenty-four participants had prodromal PD; 9 met criteria for probable prodromal PD and investigators identified concern for parkinsonism in 20 cases. Compared with those without prodromal PD, participants with prodromal PD were older (63.9 years [9.0] vs 51.9 years [15.1], p < 0.001), had higher modified Movement Disorders Society-Unified Parkinson's Disease Rating Scale motor scores (5.7 [4.3] vs 0.8 [2.1], p < 0.001), and had higher Scale for Outcomes in PD for Autonomic Symptoms scores (11.5 [6.2] vs 6.9 [5.7], p = 0.002). Two-thirds of participants enrolled were new to research, 97% were satisfied with the overall study, and 94% of those without PD would participate in future preventive clinical trials. Discussion An entirely remote national cohort of LRRK2 G2019S carriers was recruited from a single site. This study will prospectively characterize a large LRRK2 G2019S cohort, refine a new model of clinical research, and engage new research participants willing to participate in future therapeutic trials.
Appendicular myology and relationships of the shrikes (Aves: Passeriformes: Laniidae)

The appendicular musculature was dissected in 18 species of passerine birds in the family Laniidae (shrikes and their allies). A cladistic analysis of variations in the limb muscles, supplemented by other information, was used to construct a hypothesis of evolutionary relationships in the family. Monophyly of the family as currently recognized was not refuted, but corroborating data are weak. The subfamily Malaconotinae (bush-shrikes) is a coherent assemblage of primitive species. The true shrikes (subfamily Laniinae) have hind limb muscular specializations apparently unique among passerine birds. The helmet-shrikes (subfamily Prionopinae) have a distinct pattern of hind limb adaptations. The Bornean Bristlehead, Pityriasis gymnocephala (subfamily Pityriasinae), an aberrant oscine of disputed affinities, is most likely the primitive sister taxon of the Prionopinae.
HSOA Journal of Food Science and Nutrition Minor Millets: Abandoned Grains with Promising Prospects

products from minor millets and also to evaluate the shelf life of millets under various processing techniques applied. Abstract Despite the fact that the green revolution helped India become self-sufficient, the productivity of the wheat rice cropping system is now approaching stability. Agricultural diversification is required in order to introduce traditional grains that are both environmentally friendly and nutritionally sufficient. Millets are small seeded grasses that appear to meet this requirement. These are eco-friendly and have a well-balanced macronutrient and micronutrient composition. Millets also have nutraceutical properties and can help to prevent a variety of non-communicable diseases. Soaking, roasting, germination, and fermentation procedures improve the palatability of millets while simultaneously reducing anti-nutrients, enhancing the physiochemical accessibility of micronutrients and improving their bioavailability. Preparing value-added products and popularising them among the general public can boost millet demand as well as farm-er’s income. It is necessary to develop and popularise millet-based food products that provide poor people with convenience, flavour, texture, colour, and shelf-stability at a low cost.
Skrb vzbujajoče spremembe v mobilnosti mladih – primer osnovnošolcev v Novem mestu

Tema prispevka so potovalne navade mladih v Sloveniji v zadnjih tridesetih letih in poskus pojasnitve razlogov za njihove popolnoma spremenjene potovalne vzorce. V prispevku se osredotočamo na potovalne navade osnovnošolcev, ki so posebna skupina udeležencev v prometu in uporabnikov mestnega prostora. Primerjamo podatke iz let 1991, 2001 in 2016 o potovalnih navadah osnovnošolcev, lastništvu osebnih avtomobilov, lokacijah osnovnih šol in velikosti šolskih okolišev ter prometni ureditvi v okolici osnovnih šol. V prispevku ugotavljamo, da rezultati v Sloveniji sovpadajo z ugotovitvami iz tujine. Velike spremembe v potovalnih vzorcih otrok časovno sovpadajo z intenzivno motorizacijo slovenskih mest, ki je dosegla večje razsežnosti kot v marsikateri razvitejši državi. Povečano lastništvo avtomobilov se kaže v njihovi povečani rabi. Aktivnosti, ki trenutno potekajo na šolah na področju urejanja prometa, ne prispevajo k ustavitvi tega trenda. Potrebna bo sprememba v paradigmi prometne varnosti. Ukvarjanje z mobilnostjo otrok mora postati del celostnega prometnega načrtovanja, ki si mora prizadevati za zmanjšanje in umirjanje osebnega motornega prometa v okolici šol z vzpostavljanjem razmer, ki niso prijazne uporabi osebnih motornih vozil in spodbujajo varno rabo aktivnih alternativ.
Existence of solutions for a viscous hybrid quantum system for arbitrary large current density

In this paper, we continue to analyse the properties of the hybrid model introduced in the works by Chiarelli et al. and Di Michele et al. In particular, we consider a quantum hybrid model with a special viscous functional, as introduced in the work by Gamba and Jüngel, for the quantum hydrodynamical model in its standard form (QHD). We show that the hybrid QHD (H-QHD) model admits weak solutions also for arbitrary large value of the current density J under a suitable pressure function.
A Bioinformatics Study of Ropivacaine plus Dexamethasone Prolonging the Duration of Nerve Block

The study focuses on the potential function of dexamethasone on ropivacaine in sciatic nerve blocks. Nine Sprague–Dawley (SD) rats were randomly divided into three groups: normal group (NG), control group (CG), and experimental group (EG), with three rats in each group. The CG was injected with diluted ropivacaine (0.5% concentration); the EG was injected with a diluted ropivacaine+dexamethasone mixture, and the NG was injected with an equal amount of saline. The sciatic nerve in the thigh was collected for sequencing two days after injection in each group. Differential analysis was performed for NG-vs-CG, NG-vs-EG, and CG-vs-EG based on the sequencing dataset. The modular genes associated with ropivacaine and ropivacaine+ dexamethasone were screened by weighted coexpression network analysis (WGCNA), differentially expressed modules among them were enriched for analysis, and protein-protein interaction (PPI) networks were constructed to observe high and low expression among key genes in immune cells. Twenty-two and three differential genes associated with ropivacaine (green-yellow module) and ropivacaine+dexamethasone (palevioletred3 module) were acquired, respectively, which played important roles in biological processes such as erythrocyte homeostasis, erythroid differentiation, and hemoglobin metabolic processes. PPI revealed that AHSP, ALAS2, EPB42, HBB, and SLC4A1 were interacting and the expression of these five genes was upregulated in the CG compared with the NG, while the expression of them was downregulated in the EG compared with the CG. The immunological analysis also showed significant differences in the expression of various immune cells in the 3 groups. AHSP, ALAS2, EPB42, HBB, and SLC4A1 are genes associated with hemoglobin, and dexamethasone combined with ropivacaine may prolong anesthesia by affecting local vasoconstriction to some extent.
Analisis Indeks Pencemaran Sungai Ampel Desa Sletreng Kabupaten Situbondo

Sungai Ampel merupakan salah satu sungai yang berada di Desa Landangan, Kecamatan Kapongan Kabupaten Situbondo. Sungai ini digunakan masyarakat untuk mengairi persawahan, memancing, dan lain sebagainya. Adanya PT. Panca Mitra Multiperdana Tbk. yakni produsen hasil olahan udang disekitar sungai membawa dampak terhadap kualitas air sungai tersebut. Penelitian ini bertujuan untuk menganalisis kualitas air di sungai Ampel. Analisis dilakukan dengan menggunakan metode indeks pencemaran sungai berdasarkan Keputusan Menteri Lingkungan Hidup Republik Indonesia nomor 115 tahun 2003. Sungai Ampel sebagai daerah penelitian yang dialiri pipa pembuangan limbah hasil olahan udang serta dekat dengan pertambakan udang warga setempat. Pengambilan data dilakukan secara In situ dengan menggunakan botol kaca gelap ukuran 150 ml dan botol bening ukuran 600 ml, disimpan dalam coolbox. Lokasi penelitian dibagi dalam 3 lokasi titik sampling. Hasil penelitian menunjukkan bahwa analisis menggunakan indeks pencemaran di Sungai Ampel yakni pada Stasiun I sebesar 2,59, stasiun II sebesar 4,29, serta stasiun III sebesar 4,52 dimana ketiganya dikategorikan sebagai tercemar ringan.
Modélisation et simulation de la combustion dans les écoulements rapides

Dans le domaine des systemes propulsifs, le statoreacteur classique possede de bonnes performances propulsives. Neanmoins, celles-ci se degradent notablement lorsque les valeurs du nombre de Mach augmentent. Dans le regime hypersonique (au-dela de Mach 6), l'utilisation d'un statoreacteur a combustion supersonique, ou superstatoreacteur, doit permettre de surmonter ces difficultes. La simulation numerique est un des moyens d'etude de la combustion dans ces regimes d'ecoulements rapides. Elle doit alors etre capable de restituer des effets specifiques aux ecoulements a grand nombre de Mach, pour lesquels les temps caracteristiques chimiques et de melange aux petites echelles peuvent etre du meme ordre de grandeur. Ce travail de these est consacre a l'amelioration des outils de simulation de la combustion dans les ecoulements rapides en prenant en compte les effets de chimie finie et de micro-melange sur la base d'une approche de reacteur partiellement premelange. La modelisation UPaSR ainsi proposee est validee sur la base du calcul d'une flamme jet supersonique. Les simulations numeriques correspondantes conduisent a des resultats encourageants qui confirment l'importance, pour ce type de conditions, des effets cinetiques d'une part, et des effets compressibles d'autre part. Enfin, le modele UPaSR est applique a l'analyse d'une configuration plus complexe de superstatoreacteur (RESTM12) etudiee experimentalement a l'Universite du Queensland. Deux methodes differentes sont utilisees et comparees afin d'obtenir les principaux indices de performance.
A Scoping Review of the Causes and Consequences of Fraud in Sport

This study provides a structured overview of the literature published between 2010 and 2020 on the causes and consequences of fraud in sport using a systematic search strategy. Our results show that the current literature on this phenomenon is mostly focused on football as a specific type of sport, and on competition manipulation as a specific type of fraud. Guided by the routine activity theory, we observed that motivated offenders, suitable targets, and the lack of capable guardians render sport vulnerable for fraud in general, and for competition manipulation, corruption, financial fraud, and human trafficking in particular. The consequences of fraud in sport are mostly financial, through a diminution in the public's trust combined with a decrease in attendance and spectatorship to sport events. The phenomenon of fraud in sport remains strongly under-researched through empirical designs, and an interdisciplinary approach is required to tackle its complex nature and scope.
Evidence of Validity and Measurement Invariance by Gender of the Vaccination Attitudes Examination (VAX) Scale in Colombian University Students

Background: Having a valid tool to assess attitudes toward vaccination and identify the concerns that drive vaccine refusal can facilitate population studies and help guide public health interventions. The objective of this study has been to adapt the Vaccination Attitudes Examination (VAX) scale in Colombian university students and to study its psychometric properties in a non-probabilistic sample of 1074 Colombian university students. Methods: A confirmatory factor analysis was used to study the factorial structure. A structural equation model was tested to study concurrent validity and to check whether the factors predicted having received the coronavirus vaccine. Gender-based measurement invariance was also studied for the best model. Results: The results support the structure of four related factors. The composite reliability index was good for all the factors, but the average variance extracted was not as good for the second factor. There was strong measurement invariance by gender, and two factors are good predictors of being vaccinated or not. Conclusions: The VAX has shown construct and concurrent validity and is a reliable tool for evaluating attitudes towards vaccines in university students in Colombia. It may help guide the implementation of actions for the National Vaccination Plan and institutional policies.
Multilayer Flexible Printed Circuitry Planar Transformer With Integrated Series Capacitance for an LLC Converter

The LLC resonant converter is popular but needs a discrete series resonant inductor and a capacitor. In order to cut down component count, a novel multilayer flexible printed circuitry (FPC) planar transformer with integrated series capacitance and inductance is proposed in this paper. This planar transformer consists of two sets of multilayer open-ended windings coupled with each other to produce the integrated resonant capacitor. The equivalent resonant capacitance can be controlled by the number of the layers without changing the number of primary winding turns or pattern. The proposed transformer successfully integrates the resonant capacitor and the resonant inductor, into a single component. A model is established to accurately predict the equivalent series resonant capacitance of the transformer from the physical structure. Several multilayer FPC planar transformers are built to test the model. Practical measurements and theoretical results show good agreement and validate the proposed model. Finally, an LLC power converter with 94% efficiency is built to demonstrate the proper functioning of the proposed multilayer FPC planar transformer.
Progress on photovoltaic AlGaN photodiodes for solar-blind ultraviolet photodetection

Solar-blind ultraviolet photodetectors (SBPDs) have attracted tremendous attention in the environmental, industrial, mili-tary, and biological fields. Aluminum gallium nitride (AlGaN), a kind of representative III-nitride semiconductor, has promising prospects in solar-blind photodetection owing to its tunable wide bandgap and industrial feasibility. Considering the high defect density in the AlGaN epilayer directly grown on a sapphire substrate, employing an AlN/sapphire template turns out to be an effective method to achieve a high-quality AlGaN epilayer, thereby enhancing the SBPD performances. In recent years, a variety of remarkable breakthroughs have been achieved in the SBPDs. In this paper, the progress on photovoltaic AlGaN-based SBPDs is reviewed. First, the basic physical properties of AlGaN are introduced. Then, fabrication methods and defect annihilation of the AlN/sapphire template are discussed. Various photovoltaic SBPDs are further summarized, including Schottky barrier, metal-semiconductor-metal, p-n/p-i-n and avalanche photodiodes. Furthermore, surface modification and photoelectrochemical cell techniques are introduced. Benefitting from the development of fabrication techniques and optoelectronic devices, photovoltaic AlGaN photodiodes exhibit a promising prospect in solar-blind ultraviolet photodetection.
Preshearing: The evolution of manual layup

Hand layup is still widely used in the composites industry, yet it has changed little over the past few decades. This is the first attempt to study in detail the effects of modifying the layup process. An alternative two stage approach to layup is proposed, where the majority of the shear deformation is applied prior to plies contacting the tool. The new process is trialled by three participants on three separate layup tasks. Using video analysis to study the process, it was shown that the key tasks of manipulating the prepreg sheets around doubly curved features and creating in plane shear during layup were dramatically ‘simplified’. This resulted in a large reduction in the use of specialist techniques, a significant time saving and a reduction in the likelihood of defect generation.
Irreducible Green Functions Method and Many-Particle Interacting Systems on a Lattice

The Green-function technique, termed the irreducible Green functions (IGF) method, that is a certain reformulation of the equation-of motion method for double-time temperature dependent Green functions is presented. This method was developed to overcome some ambiguities in terminating the hierarchy of the equations of motion of double-time Green functions and to give a workable technique to systematic way of decoupling. The approach provides a practical method for description of the many-body quasi-particle dynamics of correlated systems on a lattice with complex spectra. Moreover, it provides a very compact and self-consistent way of taking into account the damping effects and finite lifetimes of quasi-particles due to inelastic collisions. In addition, it correctly defines the Generalized Mean Fields, that determine elastic scattering renormalizations and, in general, are not functionals of the mean particle densities only. Although some space is devoted to the formal structure of the method, the emphasis is on its utility. Applications to the lattice fermion models such as Hubbard/Anderson models and to the Heisenberg ferro- and antiferromagnet, which manifest the operational ability of the method are given. It is shown that the IGF method provides a powerful tool for the construction of essentially new dynamical solutions for strongly interacting many-particle systems with complex spectra.
KAJIAN NARATIF: HUBUNGAN OBESITAS DENGAN KEJADIAN KANKER PAYUDARA PADA WANITA

Latar Belakang: Kanker payudara menjadi penyebab utama kejadian kanker global pada tahun 2020, diperkirakan 2,3 juta kasus baru dengan kematian 685.000. Data dari Global Burden of Cancer yang dirilis oleh WHO tahun 2020 bahwa kasus baru kanker payudara di Indonesia yaitu 65.858 kasus, sedangkan kasus kematian akibat kanker payudara yaitu 22.430 kasus. Salah satu faktor risiko kanker payudara adalah obesitas. Obesitas didefinisikan sebagai akumulasi lemak abnormal atau berlebihan yang menimbulkan risiko bagi kesehatan. Tujuan: untuk mengetahui hubungan antara obesitas dengan kejadian kanker payudara pada wanita. Metode: Pencarian literatur bersumber dari Google Scholar dan PubMed yang dipublikasi dari tahun 2016-2021. Kata kunci yang digunakan digunakan adalah “Obesitas”, “Kanker Payudara”, “IMT” “Wanita”, “Obesity”,“Breast Cancer”, “BMI”,“Woman”. Dalam kajian naratif ini yaitu ada 12 artikel yang akan dikaji. Diskusi: Wanita obesitas pascamenopause memiliki risiko lebih tinggi untuk terkena kanker payuda daripada wanita pramenopause. Pada wanita obesitas pascamenopause, kanker payudara dapat berisiko pada IMT ≥30 kg/m2, sedangkan pada wanita obesitas pramenopause, kanker payudara dapat berisiko pada IMT ≥25 kg/m2. Kesimpulan: Obesitas menjadi salah satu faktor risiko kanker payudara pada wanita pramenopause dan wanita pascamenopause dengan tingkat risiko yang berbeda. Penurunan berat badan disarankan untuk wanita pramenopause dan wanita pascamenopause untuk menjaga berat badan tetap normal agar tidak terjadi obesitas.
Theoretical and Computational Investigations of Nonlinear Waves in Magnetohydrodynamics.

THEORETICAL AND COMPUTATIONAL INVESTIGATIONS OF NONLINEAR WAVES IN MAGNETOHYDRODYNAMICS by Rho Shin Myong Chairperson Philip L Roe For the purpose of developing a basic theory of the nonlinear evolution and stability of MHD waves and an approximate Riemann solver for MHD the Riemann prob lem is investigated theoretically and computationally The investigation starts with an analysis of a model system that preserves exactly the MHD singularity Shock admissibility conditions are extensively examined and it is shown that the simple geometric conditions are inappropriate for determining physically relevant shocks of non strictly hyperbolic conservation laws A viscosity admissibility condition is pro posed that ensures the uniqueness of the Riemann problem and a global analysis of the dynamical system of the model is presented By observing that the MHD sys tem is symmetrically hyperbolic a new MHD Rankine Hugoniot relation is derived and then connected with recent mathematical theories of the Riemann problem of a quadratic model system near a hyperbolic singularity As a result a proof of the well posedness of the planar MHD Riemann problem is obtained By studying the nonlinear evolution of the nite amplitude waves it is shown that the solution to the non planar Riemann problem is not necessarily unique in particular that the solu tions depend not only on left and right states but also on the associated magnetic eld moments Finally some numerical issues in developing Godunov type numeri cal methods for MHD are discussed and a new approximate MHD Riemann solver is proposed which is remarkably simple and follows exactly the way to generate the large time solution to the non planar Riemann problem from the well posed planar problem
Fuzzy Approximate Entropy of Extrema Based on Multiple Moving Averages as a Novel Approach in Obstructive Sleep Apnea Screening

Objective: Obstructive sleep apnea (OSA) is a respiratory disease associated with autonomic nervous system dysfunction. As a novel method for analyzing OSA depending on heart rate variability, fuzzy approximate entropy of extrema based on multiple moving averages (Emma-fApEn) can effectively assess the sympathetic tension limits, thereby realizing a good performance in the disease severity screening. Method: Sixty 6-h electrocardiogram recordings (20 healthy, 16 mild/moderate OSA and 34 severe OSA) from the PhysioNet database were used in this study. The performances of minima of Emma-fApEn (fApEn-minima), maxima of Emma-fApEn (fApEn-maxima) and classic time-frequency domain indices for each recording were assessed by significance analysis, correlation analysis, parameter optimization and OSA screening. Results: fApEn-minima and fApEn-maxima had significant differences between the severe OSA group and the other two groups, while the mean value (Mean) and the ratio of low-frequency power and high-frequency power (LH) could significantly differentiate OSA recordings from healthy recordings. The correlation coefficient between fApEn-minima and apnea-hypopnea index was the highest (|R| = 0.705). Machine learning methods were used to evaluate the performances of the above four indices. Random forest (RF) achieved the highest accuracy of 96.67% in OSA screening and 91.67% in severe OSA screening, with a good balance in both. Conclusion: Emma-fApEn may be used as a simple preliminary detection tool to assess the severity of OSA prior to polysomnography analysis.