Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of weight change since a young age on cardiovascular mortality risk: a pooled analysis of Japanese epidemiological evidence

*Correspondence: ahmed011172@med.bsu. edu.eg 1Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan. 2Public Health, Department of Social Medicine, Graduate School of Medicine, Osaka University, Suita, Japan. 3Department of Public Health, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt. 4Public Health Division, Ibaraki Public Health Center, Osaka Prefectural Government, Ibaraki, Japan.
Synthesis, Characterization, In vitro Antiproliferative and Cytotoxic Effect of Ruthenium(II)-Bipyridine-Benzoylpicolinic Acid Complex on SK-MEL-28 and Normal L6 Cell Lines

The most seriously spread malignant tumor of melanocytes throughout the body is a melanoma type of skin cancer. SK-MEL-28 cell line is one of a series of melanoma cell lines. The objective of the present investigation is to study the anticancer activity and cytotoxicity of novel [Ru(bpy)2(bzpic)2]2+ (bpy = 2,2ʹ-bipyridine and bzpic = 3-Benzoylpicolinic acid) complex on SK-MEL-28 and normal L6 cell lines using MTT assay method. The morphology of the cancerous SK-MEL-28 cell line at various concentrations of the [Ru(bpy)2(bzpic)2]2+ complex is assessed by 2-fold dilution method, and the in vitro antiproliferative effect of the complex on the cancerous SK-MEL-28 cell line is analyzed by direct microscopic observation method. The percentage viability of the complex on cancerous SK-MEL-28 cell line at various concentrations is determined. The IC50 value of the complex against the SK-MEL-28 cell is found to be 39.109 µg/mL which shows good antiproliferative effect. The IC50 value of the complex against normal L6 cell line is found to be 55.315 µg/mL. The results revealed that the percentage of growth inhibition of the cell is based on dose-dependent manner and the formation of formazan crystal indicates this. The fluorescent microscopy observation clearly determines that the synthesized [Ru(bpy)2(bzpic)2]2+ complex shows late apoptosis on SK-MEL-28 cell line and early apoptosis on L6 cell line. Hence, it is evident that the synthesized complex exhibits good in vitro antiproliferative effect with lower cytotoxicity. HIGHLIGHTS Synthesis of [Ru(bpy)2(bzpic)2]2+ complex Direct and fluorescent microscopic observation of [Ru(bpy)2(bzpic)2]2+ complex on SK-MEL-28 and normal L6 cell lines In vitro antiproliferative and cytotoxic effects of [Ru(bpy)2(bzpic)2]2+ complex on SK-MEL-28 and normal L6 cell lines GRAPHICAL ABSTRACT
Incremental Doses of Nitrate-Rich Beetroot Juice Do Not Modify Cognitive Function and Cerebral Blood Flow in Overweight and Obese Older Adults: A 13-Week Pilot Randomised Clinical Trial

Nitrate-rich food increases nitric oxide (NO) production and may have beneficial effects on vascular, metabolic, and brain function. This pilot study tested the effects of prolonged consumption of a range of doses of dietary nitrate (NO3−), provided as beetroot juice, on cognitive function and cerebral blood flow (CBF) in overweight and obese older participants. The study had a 13-week single-blind, randomised, parallel design, and 62 overweight and obese older participants (aged 60 to 75 years) received the following interventions: (1) high NO3− (2 × 70 mL beetroot juice/day) (2) medium NO3− (70 mL beetroot juice/day), (3) low NO3− (70 mL beetroot juice on alternate days), or (4) placebo (70 mL of NO3−-depleted beetroot juice on alternate days). Cognitive functions were assessed using the Computerised Mental Performance Assessment System (COMPASS) assessment battery. CBF, monitored by concentration changes in oxygenated and deoxygenated haemoglobin, was assessed in the frontal cortex using near-infrared spectroscopy. The findings of this pilot study showed that cognitive function and CBF were not affected by supplementation with NO3−-rich beetroot juice for 13 weeks, irrespective of the NO3− dose administered. These findings require confirmation in larger studies using more sophisticated imaging methods (i.e., MRI) to determine whether prolonged dietary NO3− supplementation influences brain function in older overweight people.
Pharmacokinetics and Pharmacodynamics of YYD601, a Dual Delayed-Release Formulation of Esomeprazole, Following Single and Multiple Doses in Healthy Adult Volunteers Under Fasting and Fed Conditions

Background YYD601 was developed as a novel dual delayed release (DDR) formulation of esomeprazole to prolong the plasma esomeprazole concentration and extend the duration of acid suppression. Purpose The pharmacokinetic (PK) and pharmacodynamics (PD) characteristics of YYD601 after single and multiple oral administrations were investigated in healthy Korean adults under fasting and fed conditions, and compared with the original esomeprazole capsule. Methods In the single-center, randomized, open-label, parallel-design, two-period study, thirty two volunteers were enrolled into four dosing groups, including esomeprazole 40-mg (group A), YYD60130-mg (group B), YYD601 40-mg (group C), and YYD601 60-mg (group D) once daily for 5 days. Blood samples were collected for PK analysis, before and up to 24 h after dosing. For PD characteristics of YYD601, the percentages of time with intragastric pH > 4 over a 24-h period and during night-time following multiple oral administrations were evaluated. Results A total of 27 subjects completed the study. YYD601 showed a dual-peak PK profile under fasting condition, with delayed Tmax, compared with conventional formulation. There were no significant differences in the AUC values adjusted for dose between the three YYD601 dosage groups and the conventional esomeprazole 40 mg. The esomeprazole AUC following single and multiple administration decreased with food intake by approximately 33%. YYD601 showed a linear pharmacokinetic profile in the dose range studied. There was no statistically significant difference in increase in mean percentage of time with intragastric pH > 4 for 24-hour and during night-time between the three different doses of YYD601 and the conventional formulation. The treatments were well-tolerated during the study and no serious adverse events were observed. Conclusion YYD601 30 mg has a comparable effect on gastric acid inhibition as conventional esomeprazole 40 mg following once daily oral administration. Single and multiple oral dosing of YYD601 up to 60 mg were safe and well-tolerated throughout the study. Clinical Trial Registry http://clinicaltrials.gov, NCT03558477 (date of registration: June 15, 2018; study period: between October 2017 and February 2018).
Effects of PGPR, AMF and Trichoderma Applications on Adaptation Abilities to Different Biotic and Abiotic Conditions in Medicinal and Aromatic Plants

Medicinal and aromatic plants are valuable sources of herbal products worldwide due to their secondary metabolite content, high antioxidant activities and many other biological activities. As a result of the developing technology, the demand for natural active substances obtained from plants has increased. For use, plants collected from nature do not have the desired quality standards. For this reason, sustainability can be achieved by using microbial inoculants as well as many biotechnological and molecular approaches such as micro propagation, synthetic seed technology to increase the yield and quality standards of medicinal and aromatic plants. Thanks to microbial inoculants, yield increase can be realized and at the same time, product quality can be contributed due to increased soil quality. In this review, it was aimed to evaluate the important roles of plant growth promoting rhizobacteria (PGPR), Arbiscular mycorrhizal fungi and Trichoderma inoculants in increasing productivity, nutrient uptake and resistance of medicinal and aromatic plants to environmental stresses in the light of literature. In this review, the variation in the resistance of plants to environmental stresses is summarized by evaluating the ultimate effects of microbial inoculants alone and in combination. In addition, it has been added to the evaluation in studies to prevent the decrease of secondary metabolite content formed under environmental stress conditions in medicinal and aromatic plants by microorganisms.
Kex: A Platform For Analysis Of JVM Programs

Introduction: Over the last years program analysis methods were widely used for software quality assurance. Different types of program analysis require various levels of program representation, analysis methods, etc. Platforms that provide utilities to implement different types of analysis on their basis become very important because they allow one to simplify the process of development. Purpose: Development of a platform for analysis of JVM programs. Results: In this paper we present Kex, a platform for building program analysis tools for JVM bytecode. Kex provides three abstraction levels. First is Kfg, which is an SSA-based control flow graph representation for bytecode-level analysis and transformation. Second is a symbolic program representation called Predicate State, which consists of first order logic predicates that represent instructions of the original program, constraints, etc. The final level is SMT integration layer for constraint solving. It currently provides an interface for interacting with three SMT solvers. Practical relevance: We have evaluated our platform by considering two prototypes. First prototype is an automatic test generation tool that has participated in SBST 2021 tool competition. Second prototype is a tool for detection of automatic library integration errors. Both prototypes have proved that Kex can be used to implement competitive and powerful program analysis tools.
Microrredes basadas en electrónica de potencia: parte II: control de potencia activa y reactiva

Since the mid-70s and following the oil crisis, much research has been developed in order to diversify energy sources and decoupling the world economy from fossil fuels. At present, the development of technologies to harness alternative energies, the increased of small-scale storage systems and communication technologies to link and command these elements have begun a transformation of the electricity grid, introducing the concept of intelligent grid (Smart Grid). The intermediate step in this transition is to create areas of the grid that have the "intelligence" to link distributed storage and generation to the grid, keeping high standards of quality and reliability at reasonably low prices; these sections of the grid are called micro-grids, a novel feature of the micro-grids is the possibility to participate in the energy market, as a "virtual unit" grouping all their demand and generation to interact with the market. This paper presents a brief introduction about micro-grids and provides an overview of the use of technologies for security, operation, management and its control.
Revisiting the Effect of Trustworthy Face and Attractive Appearance on Trust and Trustworthiness Behavior

In a trust game experiment with Chinese participants, we investigate the effects of trustworthy faces and attractive appearances on trust and trustworthiness behavior. The participants played the role of trustor and made decisions on how much money to transfer to their paired trustees while looking at the trustees’ photos presented on a large screen. After that, the trustees decided how much money to return to their paired trustors. Results indicate that trust decisions are influenced by both a trustworthy face and an attractive appearance. In addition, a gender effect on trust decisions was found. Men are more trusting than women are, regardless of whether their counterparts are male or female. However, females are less likely to trust their male counterparts than female counterparts. Finally, it is observed that the trustees with a more attractive appearance are more likely to betray the trust they have, while this is not the case for those with more trustworthy faces.
The Bacillus cereus Strain EC9 Primes the Plant Immune System for Superior Biocontrol of Fusarium oxysporum

Antibiosis is a key feature widely exploited to develop biofungicides based on the ability of biological control agents (BCAs) to produce fungitoxic compounds. A less recognised attribute of plant-associated beneficial microorganisms is their ability to stimulate the plant immune system, which may provide long-term, systemic self-protection against different types of pathogens. By using conventional antifungal in vitro screening coupled with in planta assays, we found antifungal and non-antifungal Bacillus strains that protected the ornamental plant Kalanchoe against the soil-borne pathogen Fusarium oxysporum in experimental and commercial production settings. Further examination of one antifungal and one non-antifungal strain indicated that high protection efficacy in planta did not correlate with antifungal activity in vitro. Whole-genome sequencing showed that the non-antifungal strain EC9 lacked the biosynthetic gene clusters associated with typical antimicrobial compounds. Instead, this bacterium triggers the expression of marker genes for the jasmonic and salicylic acid defence pathways, but only after pathogen challenge, indicating that this strain may protect Kalanchoe plants by priming immunity. We suggest that the stimulation of the plant immune system is a promising mode of action of BCAs for the development of novel biological crop protection products.
Hierarchical fuzzy‐based Quality of Experience (QoE)‐aware application placement in fog nodes

Fog computing or a fog network is a decentralized network placed in between data source and the cloud to minimize the network latency issues and thus support in‐time service delivery, of Internet of Things (IoT) applications. However, placing computational tasks of IoT applications in fog infrastructure is a challenging task. State of the art focuses on quality of service and quality of experience (QoE) based application placement. In this article, we design hierarchical fuzzy based QoE‐aware application placement strategy for mapping IoT applications with compatible instances in the fog network. The proposed method considers user application expectation parameters and metrics of available fog instances, and assigns the priority of applications using hierarchical fuzzy logic. The method later uses Hungarian maximization assignment algorithm to map applications with compatible instances. The simulation results of the proposed policy show better performance over the existing baseline algorithms in terms of resource gain (RG), processing time reduction ratio (PTRR), and similarly network relaxation ratio. When considering 10 applications in the fog network, our proposed method simulation results show 70.00%, 22.44%, 37.83% improvement in RG, and 28.46%, 37.5%, 23.07% improvement in PTRR, when compared with QoE‐aware, randomized, FIFO algorithms, respectively.
Homing ability in a tropical Asian stingless bee is influenced by interaction between release distances and urbanisation

Bee homing capacity determines the maximum distance/area from/around the nest that workers can travel to exploit resources. However, homing ranges have been hardly examined in tropical Asian stingless bee species or in relation to anthropogenic land‐use changes. Here, we used translocation experiments, where we released marked bees at different distances from the colony, to evaluate the maximum homing distance of Tetragonula fuscobalteata in 10 different anthropogenic landscapes in Southern Thailand. Our results show that typical and maximum homing distances (i.e., distances where 50% and 90% of released bees failed to return, respectively) were estimated to be 240 and 595 m, respectively. We found that bee homing rates were not affected by forest proximity or surrounding landscape composition within 100, 200, 300, 400, 500 and 600 m radii, but that they were influenced by the interaction between release distances from the colony and the proportion of urbanised cover at a 100 m radius. Bee homing rates decreased with increasing release distances for colonies placed in areas with higher proportions of urbanised land within a 100 m radius. This suggests that urbanised areas (e.g., urban or suburban gardens, home gardens, backyards) provided sufficient food resources close to colonies, resulting in smaller foraging ranges.
Effect of Biochar, Compost and bio-fertilizer on Pea Yield Then, Study its Residual Effect on the Subsequent Pepper Crop

Two field experiments were carried out at two successive seasons of 2018 and 2019 to study the direct effect of biochar, com post and bio-fertilizer (N fixing bacteria as Rhizobium leguminosarum for pea or azotobacter for sweet pepper and phosphorus solubilizing microorganisms as phosphoren) under three rates from the recommended mineral fertilizer and their interaction on pea plants ( Pisum sativium ) cv. Entsar 1 as first experiment and the residual influence of the previous fertilizers on sweet pepper plants ( Capsicum annuum L . ) cv. California wonder which was planted as second experiment crop. The results according to pea plants gave the best growth attributes, yield and its components were registered by the treatment of biochar with compost and fertilizer. Regarding to the residual influence of biochar, compost and bio-fertilizer led to high values on growth, yield and its characters of sweet pepper fruits in both growing seasons.
Evolving Dimension of Security: Bioterrorism

Bioterrorism became a burning issue in the USA after the human-induced incidence of Anthrax and the attack on WTO in 2001. At present, the world is trapped in the COVID 19 pandemic having an estimated monetary loss of 76.69 billion USD, engulfed more than 4.5 million people, and 211 million suffering to date. There is increasing concern toward bioterrorism globally which can happen either intentionally or due to poor laboratory practices. In recent decades technological progress in bioscience has simplified the development of bioweapons. Moreover, the advancement of genetic engineering is chronic biologically. Over a hundred pathogens have been identified as possible bioterrorism agents. The research article aims to explore bioterrorism as an evolving dimension of threat to the public and national security in developing countries like Nepal. In present article introduction section deals with background, statement of the problem and rationale of our study. The main body deals with biological agents of bioterriorism and their targets, history, present scenario of bioterrorism. Finally, awareness and control measures, challenge and prospects of biosecurity in Nepal. The ubiquity of biological equipment, technical knowledge and ease of production has stimulated the threat of bioterrorism. Some of the challenging dimensions are agroterrorism and bioterrorism because the attack is very difficult to detect and has a devastating effect in a short period. The social and environmental consequences of these attacks can be catastrophic. The study revealed that it would be better to pay attention and go for precaution before the occurrence of bioterror. Improving forensic techniques of the national security wing for detecting and disabling biological weapons will assist in rapid detection. The restriction against easy access to potential bioagents, physical protection, border controls, risk policies and strict law enforcement are the major steps for ensuring biosecurity.
Advancement in the child attachment interview and the child and adolescent reflective functioning scale using a PDM-2 framework: case reports

The Child Attachment Interview (CAI) is a well-established semi-structured interview, widely used to identify attachment representations in middle childhood and adolescence. The application of the Child and Adolescent Reflective Functioning Scale (CRFS) to CAI narratives allows for an assessment of child mentalization, considered a strong predictor of attachment security. The 2nd edition of the Psychodynamic Diagnostic Manual (PDM-2) includes CAI and CRFS as valid and reliable assessment measures in order to assess the dominion of the Mental Functioning axis. The aim of the present paper is to investigate the informative power of CAI and CRFS for the overall understanding of mental functioning and personality in a PDM-2 framework. The present report includes the discussion of two clinical cases of school-aged children in applying the Psychodiagnostic Chart-Second Edition (PDC-2) to the CAI transcript. The first case concerns a young male, aged 10, suffering from Oppositional-Provocative Disorder (externalizing disorder), while the second case concerns a young female, aged 15, suffering from Somatic Symptoms Disorder (internalizing disorder). PDC-2 for children and adolescents was used. Data from the scoring of CAI and CRFS were combined with a systematic evaluation of the qualitative contents emerging from CAI transcripts. A detailed analysis suggests that both the CAI and CRFS are useful attachment-oriented measures, able to explore child’s mental states, and together with the application of PDC-2 they provide an essential contribution in the understanding of developmental psychopathology. Implications of this innovative approach for clinical assessment, treatment design, and interventions are further discussed.
New RPL Protocol for IoT Applications

The Objective Function (OF) can be used by the Routing protocol for low power lossy networks (RPL) to construct a Destination Oriented Directed Acyclic Graph (DODAG) based on routing metrics. The standard OFs suffer from long hops when selecting the route, which may cause consume the node’s energy faster. In this paper, we suggest an improvement of RPL OF that considers three metrics. The results show that the proposed protocol increases network lifetime by reducing energy consumption, increasing efficiency, increasing Packet Delivery Ratio (PDR), and decreasing packet loss ratio. In terms of PDR, packet loss ratio, and average power consumption, the best performance of the proposed protocol is shown in the network with 70 nodes and when the transmission range is 50m. Compared with the MRHOF, the proposed protocol increased the PDR by 58.425%, decreased the packet loss ratio by 0.21765, and decreased the total power consumption by 181.815mW. In terms of the average Expected Transmission Count (ETX) the best performance of the proposed protocol is shown in the network with 60 nodes and the transmission range is 40m. The proposed protocol reduced the average ETX by 49 compared to the MRHOF.
THREE-DIMENSIONAL NUMERICAL OPTIMIZATION OF THE MANIFOLD MICROCHANNEL HEAT SINK

The microscale heat transfer is an important cooling technique developed in recent years and applied widely to cool the Large Scale Integrated Circuit. The heat accumulation is a bottleneck for increasing the power of laser systems, for example, the heat flux can sometimes reach 400 W/cm2 on the surface of a 10 mm×1 mm diode laser bar. In the paper the structure of a copper heat sink for cooling high-power diode laser bar is optimized. Water is used as a coolant. The result shows that the structure of microchannel heat sink is important to affect the thermal resistance, pump power and temperature distribution on the surface of high-power diode laser bar. And the most important effect on the pump power is the width of the microchannel inlet and outlet.