Miracle-dz/UniFAR-FTUs huggingface dataset:
Physical, chemical composition and umami compound of dried immature
 and mature roes of skipjack tuna (Katsuwonus
 pelamis)

In this study we investigate physical and chemical characteristics of immature and mature skipjack tuna ( Katsuwonus pelamis ) roes in fresh and dried forms. Fresh roes were studied for histological structure and also dried by three methods: hot air drying (HD), vacuum drying (VD) and freeze drying (FD). The obtained roe powders were analysed for proximate composition, color value, fatty acid composition, amino acid profile, equivalent umami concentration (EUC) and protein pattern. Unyolked oocytes were more common in immature roes, while fully yolked oocytes were more common in mature roes. All dried tuna roes contained high content of protein and lipid (69.31%–70.55% and 11.14%–16.02%, respectively). The powders obtained by FD provided the highest lightness value (L*). The main fatty acid found in all roe powders was docosahexaenoic acid (DHA) (23.49%–27.02%). Glutamic acid, leucine, and aspartic acid were the three most abundant amino acids found in the powders (13.58–14.61, 8.06–8.42, and 7.81–8.39 g/100 g of protein, respectively). The mature roe powder obtained from HD provided the highest EUC value (73.09 g monosodium glutamate/100 g of samples). The protein band at molecular weight of 97 kDa (vitelline) represented the major protein. Therefore, dried tuna roe could be a functional ingredient source of protein and lipid rich in DHA and it also has potential to be used as taste enhancer with umami compound.
Research progress and enlightenment on the application of social media in tourism abroad

With the wide application of information technology in tourism, new technologies and applications have a profound impact on the development of tourism, and promote the transformation of tourism research paradigm. Based on social media and closely combined with the reality of tourism, based on the review, the studies on social media and travel abroad related definition, the types of social media from social media, social media impact on tourism subject and object, social media applications in tourism in four aspects has carried on the summary and review. It is found that the foreign research on social media and tourism is in a rapid development stage. The profound impact of social media on tourism has gradually been recognized by scholars, but the breadth and depth of research still need to be strengthened. Finally, relevant research enlightenment is proposed from the perspective of basic theory and practical application.
Computational fluid dynamics (CFD) study of patients suffering coarctation of the aorta (CoA) for pre and post-operative

I would like to express my thanks for all who helped in making this study possible. My supervisors Dr. Elmorsi and Dr. El-Khodary, for their scientific support and guidance. Dr.-Ing. Heba Aguib and Magdi Yacoub Foundation (MYF), for their support in the medical area and providence of the data of the patients. Dr. Ryo Torii for sending the MatLab and FORTRAN codes used for mapping the boundary conditions from the PC-MRI. Engr. Amr Sami, Engr. Mohamed Osman, Engr. Mohamed Atef, Engr. Hani Mashaal and other people working in OPTUMATICS, for their technical advises.
Different Prognostic Values of Tumour and Nodal Response to Neoadjuvant Chemotherapy Depending on Subtypes of Inflammatory Breast Cancer, a 317 Patient-Study

Simple Summary Inflammatory breast cancer is a rare entity associated with a poor prognosis, especially for the triple-negative subtype. This study investigates the independent prognostic value of tumour and nodal responses after neoadjuvant chemotherapy. It shows that tumour and lymph node responses did not have the same prognostic value regarding HR and HER2 statuses. We identified a subgroup of patients with triple-negative inflammatory breast cancer with residual lymph node disease for whom adjuvant treatment intensification may be worth investigating. Abstract Inflammatory breast cancer (IBC) is a rare entity with a poor prognosis. We analysed the survival outcomes of patients with nonmetastatic IBC and the prognostic value of tumour or nodal responses to assess their individual prognostic impact across IBC subtypes. This retrospective multicentre study included patients diagnosed with IBC between 2010 and 2017 to account for advances in neoadjuvant systemic therapies and modern radiotherapy at seven oncology centres in France. Three hundred and seventeen patients were included and analysed. After a median follow-up of 52 months, the 5-year DFS was lower for triple-negative (TN) (50.1% vs. 63.6%; p < 0.0001). After multivariate analyses, incomplete nodal response was the only significant prognostic factor in the triple-negative group (HR:6.06). The poor prognosis of TN-IBC was reversed in the case of nodal response after neoadjuvant chemotherapy. Breast response does not appear to be a decisive prognostic factor in patients with TN-IBC compared to lymph node response. Despite improvements in neoadjuvant treatments, IBC remains associated with a poor prognosis. In TN-IBC patients, lack of pathological complete node response was associated with poorer survival than any other group. Treatment intensification strategies are worth investigating.
Historical narratives as strategic resources: analysis of the Turkish international contracting sector

Abstract The Turkish contracting sector has an enviable reputation for operating in high-risk international markets. The sector’s ability to respond to market instability could meaningfully be construed as sectoral-level capability. We aim to demonstrate how history can be mobilised in a formalised “strategy text” to create a strategic narrative on the sectoral level. The Geography of Contractors as published by the Turkish Contractors Association (TCA) ostensively portrays the strategic development of Turkish international contractors over four decades. Such quasi-historical narratives are routinely mobilised for the purposes of creating a shared memory on the sectoral level. The chosen strategy text draws from multiple narrative fragments derived from past experience to generate a strategic agenda for the future. The representation given to multiple voices reflects the pluralistic nature of strategy making praxis. The overarching strategy narrative reflects a performative intent in legitimising some practices whilst discrediting others. Narrative analysis demonstrates the way in which actors, actions and events are positioned within a plot structure, with direct implications for the enactment of future strategic practices. The findings suggest that strategic actions can only ever be identified in retrospect and that such arguments are always made with an eye on the future.
An analytical approach to study the loading behavior of hollow fibers under negative pressure and atmospheric pressure

Hollow fibers have been widely used as important components of membranes for drug delivery in the medical field. However, their usages in environmental and agricultural aspects have not been commonly unearthed. In our previous research, a new drug delivery system was established by utilizing hollow fiber as a carrier to convey medical substances in different phases, respectively. Our current research aims to expand the application of hollow fibers apart from medicine. In this study, the loading efficiency of the liquid under standard atmospheric pressure (nonvacuum) and negative pressure (vacuum) were further examined to achieve a higher loading system. The physical properties and the loading abilities of the three types of hollow fibers including original short crimped fibers, fibers from roving yarns, and fibers from spun yarns were studied and discussed. In-depth investigations of loading efficiency, wicking performance, water absorption, and thermal conductivity were conducted. Higher loading efficiency was observed by adopting the method of vacuum under negative pressure resulting from all experiments of which the result was at least 15 times higher than the nonvacuum-loaded methods. It was also at least 0.25% greater in moisture content, almost two times larger in the water absorption rate for yarn samples, and 35% higher for fabric samples. The differences in thermal conductivity within the two conditions were 0.00016 W/cm°C. Using the vacuum approach can improve the overall performance of precise liquid loading, increasing the efficiency and thereby reduce the production costs. It is believed to bring high-value advantages in agricultural aspects such as for sustainable pest control and crop growth.
Immobilization of Clostridium perfringens type D in calcium alginate beads: toxin production mimics free cell culture

Background and Objectives: Cell-immobilization is used to maintain microbial culture to produce metabolites in repeated-batch or continuous fermentations, thereby reducing the time and resources spent on delivering mass production of microbe. The technique also enables shortening of the detoxification phase and the amount of formaldehyde required due to low incidence of viable bacteria in the extract. Materials and Methods: A solution of sodium alginate containing Clostridium perfringens cells was dropped into stirring CaCl solution via a sterile syringe needle. Optimizations resulted in reasonably uniform beads containing C. perfringens. Beads were externally stabilized by poly L-lysine, followed by immersion in a solution of Na-alginate to coat them with a new layer of alginate forming an alginate-PLL-alginate cortex. Results: This study proved successful in immobilizing C. perfringens cells inside uniform alginate microspheres. Cell loading and cell propagation inside the beads were measured. The cell loaded beads were cultivable in liquid media producing 550 minimum lethal doses per milliliter (MLD/ml) in a 72 h. Conclusion: The research paved the way for further investigations to optimize and establish an efficient bacterial encapsulation method. Thus, it seems possible to produce toxins from beads engulfing C. perfringens on larger scales via repeated-batch or continuous fermentation processes.
Personalized Predictive Modeling of Subfoveal Choroidal Thickness Changes for Myopic Adolescents after Overnight Orthokeratology

The changes in subfoveal choroidal thickness after orthokeratology are crucial in myopia retardation; this study aimed to identify the risk factors that could be incorporated into a predictive model for subfoveal choroidal thickness (SFChT) that would provide further personalized and clinically specific information for myopia control. A one-year prospective study was conducted in the West China Hospital, Sichuan University. Basic information (age, gender, and height) was collected from all subjects. Initial spherical equivalent, axial length, intraocular pressure, central corneal thickness, and subfoveal choroidal thickness were measured, and the ocular environmental factors were also collected. All the measured parameters were recorded in the follow-up period for one year. After the analysis of univariate analysis, statistically significant factors were substituted into the multivariate three-level model. Thirty-three adolescents aged 8–14 years old were enrolled in this study; the results show that the subfoveal choroidal thickness in both eyes changed significantly after 12 months of lens wearing (pR < 0.0001, pL < 0.0001). The axial length was negatively correlated with the change in the SFChT after 12 months of lens wearing (r = −0.511, p = 0.002). After multilevel model analysis, the statistically significant factor was shown to have an important influence on the changes in the subfoveal choroidal thickness, which was the average near-work time. This suggested that the SFChT personal predictions can be made regarding changes in myopic adolescents after orthokeratology using the factor of daily average near-work time. Clinical practitioners will benefit from the results by obtaining a better understanding of the effects of orthokeratology on choroid and myopia progression.
The Quality of Frozen Semen of Limousin Bull in Various Semen Diluents

Diluents are substances added to the semen to increase the semen volume, reduce sperm density, and maintain sperm viability. This study aimed to compare the effects of various semen diluents on the quality of frozen semen of Limousin bull. Three mature Limousin bulls were used as semen sources. The semen was collected using an artificial vagina and then evaluated for its quality. Sperms with motility less than 70% and abnormality greater than 20% were excluded from this study. After semen evaluation, each ejaculate was individually divided into four equal tubes and diluted with skimmed milk-egg yolk (SMEY), Tris–egg yolk (TEY), Tris–egg yolk–skimmed milk (TEYSM), or Andromed ® . Diluted semen was loaded into a mini straw and then equilibrated at 5 °C for 4 h. Following equilibra-tion, the straws were frozen. The percentages of sperm motility, viability, intact membrane, and sperm DNA integrity were evaluated after freezing. Furthermore, malondialdehyde (MDA) and aspartate aminotransferase (AST) enzyme concentrations were assessed after thawing. The sperm motility with TEY, TEYSM, and Andromed ® did not differ significantly but was higher than with SMEY. Sperm viability, membrane intactness, and sperm DNA integrity did not differ among treatments. By contrast, the MDA levels and concentration of AST in the Andromed ® diluent semen showed the lowest values compared with SMEY semen (p<0.05) but did not differ from those of TEY and TEYSM semen. To conclude, TEY, TEYSM, and Andromed ® diluents performed equally well, and although they showed better results than SMEY, sperm diluted in SMEY are still suitable for artificial insemination.
Glymphatic System a Window on TBI Pathophysiology: A Systematic Review

Background: In recent years, the attention of the scientific world has focused on a clearance system of brain waste metabolites, called the glymphatic system, based on its similarity to the lymphatic system in peripheral tissue and the relevant role of the AQP4 glial channels and described for the first time in 2012. Consequently, numerous studies focused on its role in organ damage in cases of neuropathologies, including TBI. Methods: To evaluate the role that the glymphatic system has in the pathogenesis of TBI, on 23 March 2022, a systematic review of the literature according to PRISMA guidelines was carried out using the SCOPUS and Medline (via PubMed) databases, resulting in 12 articles after the selection process. Discussion and conclusion: The present review demonstrated that an alteration of AQP4 is associated with the accumulation of substances S100b, GFAP, and NSE, known markers of TBI in the forensic field. In addition, the alteration of the functionality of AQP4 favors edema, which, as already described, constitutes alterations of secondary brain injuries. Moreover, specific areas of the brain were demonstrated to be prone to alterations of the glymphatic pathway, suggesting their involvement in post-TBI damage. Therefore, further studies are mandatory. In this regard, a study protocol on cadavers is also proposed, based on the analyzed evidence.
Atomic Details of Biomineralization Proteins Inspiring Protein Design and Reengineering for Functional Biominerals

Biominerals are extraordinary materials that provide organisms with a variety of functions to support life. The synthesis of biominerals and organization at the macroscopic level is a consequence of the interactions of these materials with proteins. The association of biominerals and proteins is very ancient and has sparked a wealth of research across biological, medical and material sciences. Calcium carbonate, hydroxyapatite, and silica represent widespread natural biominerals. The atomic details of the interface between macromolecules and these biominerals is very intriguing from a chemical perspective, considering the association of chemical entities that are structurally different. With this review I provide an overview of the available structural studies of biomineralization proteins, explored from the Protein Data Bank (wwPDB) archive and scientific literature, and of how these studies are inspiring the design and engineering of proteins able to synthesize novel biominerals. The progression of this review from classical template proteins to silica polymerization seeks to benefit researchers involved in various interdisciplinary aspects of a biomineralization project, who need background information and a quick update on advances in the field. Lessons learned from structural studies are exemplary and will guide new projects for the imaging of new hybrid biomineral/protein superstructures at the atomic level.
Markov Reliability Model for Heat Meters

Abstract The reliability of thermal energy meters is analysed using the Markov model which describes the operation of these meters in a large number of apartments and offices by a media accounting company. The data has been extracted from a relational database storing information on the operation, installation and exchange of these measures from the last 10 years. The built Markov model turned out to be ergodic, which allowed determining its limiting distribution. In addition, the probability distributions for the cumulated consumption were determined in the work - separately for all meters and meters’ failures.
The Observable Web

The web is now de facto the first place to publish data. However, retrieving the whole database represented by the web appears almost impossible. Some parts are known to be hard to discover automatically, giving rise to the so called hidden or invisible web. On the one hand, search engines try to index most of the web. Almost all related work is based on discovering the web by crawling. This paper is devoted to estimate how accurate is the view of the web obtained by crawling. Our approach is to compare crawling to other ways of discovering the web (mainly by analyzing server or proxy logs of web surfers activity). This work is a first step towards identifying the observable web.
News in the treatment of axial spondyloarthritis.

Axial spondyloarthritis is a rheumatic disease characterized by inflammation and bone formation causing impaired function of the spine and affected joints. Basic research has highlighted the key role of dysregulation of tumor necrosis factor α, interleukin- 23 and interleukin-17 cytokine production in the etiology of axial spondyloarthritis. Tumor necrosis factor α and interleukin-17 inhibitors have been shown to be effective in clinical trials and are currently approved biological disease-modifying drugs for all disease subgroups. The presumed efficacy of IL-23 blockade has not been confirmed in two clinical trials with anti-IL-23 monoclonal antibodies. Janus kinase inhibitors appear to be a new treatment option.
Tools for a comprehensive assessment of public health risks associated with limited sanitation services provision

Three water, sanitation and hygiene (WASH) support tools were applied to Kampala city, Uganda, to evaluate areas with the highest health hazard due to poor wastewater and faecal sludge management and to develop interventions to improve sanitation and reduce exposure. The Pathogen Flow and Mapping Tool (PFMT) assessed how different sanitation management interventions influence pathogen emissions to surface water using rotavirus as the indicator pathogen, while the HyCRISTAL health hazard tool evaluated how flooding and drainage infrastructure influence the presence of human excreta in the environment. The SaniPath tool identified common high-risk pathways of exposure to faecal contamination in food, open drains and floodwater. An overlap in high health hazard hotspot areas was identified by the PFMT and the HyCRISTAL tools. Across the city, the most important hazard sources were the indiscriminate disposal of faecal waste into open stormwater drains from onsite sanitation technologies, open defecation and the insufficient treatment of wastewater. The SaniPath tool identified drain water, floodwater, street food and uncooked produce as the dominant faecal exposure pathways for selected parishes in the city, demonstrating the presence of excreta in the environment. Together, the tools provide collective evidence guiding household, community, and city-wide sanitation, hygiene and infrastructure management interventions from a richer assessment than when a single tool is applied. For areas with high spatial risks, those practising open defecation, and for low-lying areas, these interventions include the provision of watertight pit latrines or septic tanks that are safely managed and regularly emptied. Faecal sludge should be emptied before flood events, direct connections of latrines to open storm drains should be prevented, and the safe handling of food and water promoted. The tools enhance decision making for local authorities, and the assessments can be replicated in other cities.
Structure-properties relationships in bioactive glasses for PAA-based polyalkenoate cements

Los cementos oseos basados en polimetilmetacrilato (PMMA) se han utilizado ampliamente en los ultimos 30 anos para aplicaciones en medicina. Sin embargo, la utilizacion de estos cementos esta relacionada con una serie de problemas, debidos por ejemplo a la presencia de monomero de PMMA no reaccionado que puede tener efectos toxicos en el organismo del huesped, y al calor producido por la exotermia de la reaccion de curado del polimero in situ. Lo cementos de ionomero de vidrio (GIC) se forman a partir de una mezcla de un acido polimerico, generalmente acido poliacrilico (PAA), con polvo de vidrio de aluminosilicato, degradable por ataque acido, en una solucion aquosa. Es importante notar que, por el hecho de ser una reaccion de salificacion antes que una polimerizacion, la exotermia asociada a la reaccion es muy baja. Ademas estos materiales pueden formar una union adhesiva entre el hueso y los metales que normalmente se emplean en cirugia ortopedica [1]. Otra caracteristica remarcable de los cementos de ionomero de vidrio es que pueden manifestar un comportamiento bioactivo en el sentido en que pueden liberar iones osteoconductivos. Asi pues, desde cuando fueron introducidos por Wilson en los anos sesenta, estos materiales han sido indicados como una alternativa valida a los cementos basados en PMMA para aplicaciones en ortopedia y, ademas, como alternativa a las amalgamas de mercurio normalmente utilizadas en odontologia. Se han producido dos series de vidrio substituyendo progresivamente calcio por magnesio y variando a la vez la fraccion molar de silicio, mientras que el contenido de sodio se ha mantenido constante a lo largo de las dos series. Para caracterizar los vidrios se han utilizado diferentes tecnicas cuales difraccion de rayos X, analisis termica y analisis del tamano de particula. Utilizando los conceptos del modelo del vidrio como polimero inorganico se ha evaluado la influencia de la sustitucion progresiva de calcio por magnesio sobre la network connectivity (NC) a traves de tecnicas de caracterizacion como espectroscopia FTIR, RAMAN y MAS-NMR. Por fin, para caracterizar las propiedades mecanicas de los cementos formados, han sido medidas la resisencia a compression y el modulo elastico. A pesar de que las teorias convencionales sobre la estructura de los vidrios reporten el magnesio como un elemento modificador de red, los resultados de este trabajo sugerien que el magnesio actua mas como un oxido intermedio, entrando en la red del vidrio antes que destruiendola. El objetivo de este trabajo es demostrar que la sustitucion de calcio por magnesio puede resultar en la posibilidad de formar un nuevo cemento de ionomero de vidrio sin alumina y con propiedades mecanicas comparables con las de los cementos oseos tradicionales.