Miracle-dz/UniFAR-FTUs huggingface dataset:
p63 Directs Subtype-Specific Gene Expression in HPV+ Head and Neck Squamous Cell Carcinoma

The complex heterogeneity of head and neck squamous cell carcinoma (HNSCC) reflects a diverse underlying etiology. This heterogeneity is also apparent within Human Papillomavirus-positive (HPV+) HNSCC subtypes, which have distinct gene expression profiles and patient outcomes. One aggressive HPV+ HNSCC subtype is characterized by elevated expression of genes involved in keratinization, a process regulated by the oncogenic transcription factor ΔNp63. Furthermore, the human TP63 gene locus is a frequent HPV integration site and HPV oncoproteins drive ΔNp63 expression, suggesting an unexplored functional link between ΔNp63 and HPV+ HNSCC. Here we show that HPV+ HNSCCs can be molecularly stratified according to ΔNp63 expression levels and derive a ΔNp63-associated gene signature profile for such tumors. We leveraged RNA-seq data from p63 knockdown cells and ChIP-seq data for p63 and histone marks from two ΔNp63high HPV+ HNSCC cell lines to identify an epigenetically refined ΔNp63 cistrome. Our integrated analyses reveal crucial ΔNp63-bound super-enhancers likely to mediate HPV+ HNSCC subtype-specific gene expression that is anchored, in part, by the PI3K-mTOR pathway. These findings implicate ΔNp63 as a key regulator of essential oncogenic pathways in a subtype of HPV+ HNSCC that can be exploited as a biomarker for patient stratification and treatment choices.
New Insights Into the Threshold Values of Multi-Locus Sequence Analysis, Average Nucleotide Identity and Digital DNA–DNA Hybridization in Delineating Streptomyces Species

Multi-locus sequence analysis (MLSA) has been proved to be a useful method for Streptomyces identification and MLSA distance of 0.007 is considered as the boundary value. However, we found that MLSA distance of 0.007 might be insufficient to act as a threshold according to the correlations among average nucleotide identity based on MuMmer ultra-rapid aligning tool (ANIm), digital DNA–DNA hybridization (dDDH) and MLSA from the 80 pairs of Streptomyces species; in addition, a 70% dDDH value did not correspond to a 95∼96% ANIm value but approximately to 96.7% in the genus Streptomyces. Based on our analysis, it was proposed that when the MLSA distance value between a novel Streptomyces and a reference strain was < 0.008, the novel strain could be considered as a heterotypic synonym of the reference strain; when the MLSA distance value was ≥ 0.014, the novel strain could be regarded as a new Streptomyces species; when the MLSA distance value was between 0.008 and 0.014 (not included), the dDDH or ANIm value between a new strain and a reference strain must be calculated in order to determine the taxonomic status of a novel strain. In this context, a 70% dDDH or 96.7% ANIm value could act as the threshold value in delineating Streptomyces species, but if the dDDH or ANIm value was less than but close to 70 or 96.7% cut-off point, the taxonomic status of a novel strain could only be determined by a combination of phenotypic characteristics, chemotaxonomic characteristics and phylogenomic analysis.
Baseline of Surface and Column-Integrated Aerosol Loadings in the Pearl River Delta Region, China

Much attention has been paid to the rapid variation of aerosol loading in the urban areas of the Pearl River Delta (PRD) region. The baseline of aerosol loading in this rapidly developing region is critical in evaluating how and why the aerosol level has evolved, which absolutely requires long-term observations. Based on long-term observations of aerosol optical depth (AOD), visibility, and particulate matter (PM) mass concentrations at Xichong (114.56°E, 22.49°N), a background site in the PRD region, the variabilities of aerosol loading at multiple temporal scales are revealed. The means (±σ) of AOD, visibility, PM10, PM2.5, and PM1 are 0.38 ± 0.07, 12.6 ± 2.3 km, 23.7 ± 12.6 μg/m3, 19.7 ± 11.0 μg/m3, and 16.1 ± 10.1 μg/m3, respectively, which show that aerosol loading at the Xichong site is much lower than that in urban and suburban sites. Significant decreases in PM10, PM2.5, and PM1 mass concentrations are observed with magnitudes up to −2.13, −1.82, and −1.37 yr−1, respectively, at a 95% confidence level. The decrease in aerosol loadings at Xichong is attributed to the strict environmental regulations for improving air quality. Higher AOD and PM (lower visibility) values are observed during the early spring months as a result of long-range transport of biomass burning from Southeastern Asia. Diurnal variations of PM and visibility are dominantly determined by those of boundary layer height and relative humidity. PM mass concentrations show a generally negative (positive) correlation with visibility (AOD) at Xichong, but the correlations are weak with the R2 of 0.22 and 0.54, respectively. Low visibility and high aerosol loading are generally associated with very weak easterly and southerly winds. Understanding of variability of surface particle concentration and column-integrated aerosol loading at this background site in the PRD region would provide a scientific basis for the adoption of pollution prevention and control measures.
Molecular Structure, Expression and Role of TAFA4 and its Receptor FPR1 in the Spinal Cord

TAFA chemokine like family member 4 (TAFA4, also named FAM19A4) is a member of the TAFA chemokine like ligand or FAM19A family, which includes TAFA1, TAFA2, TAFA3, TAFA4, and TAFA5 (or FAM19A1, FAM19A2, FAM19A3, FAM19A4, and FAM19A5). They are also referred to as neurokines and are involved in the regulation of a diverse range of cellular processes, including chemotaxis of macrophages, phagocytosis, and release of reactive oxygen species (ROS). TAFA4 is a marker of C-low-threshold mechanoreceptors and is expressed predominantly in nociceptors, such as dorsal root ganglia (DRG). TAFA4 has been implicated in the sensory perception of pain in the spinal cord. Mice with deficiency of TAFA4 demonstrate altered excitability in lamina IIi neurons in DRG in addition to increased mechanical and chemical nociception following inflammation or injury. As a secreted protein, TAFA4 binds to cell surface receptor formyl peptide receptor 1 (FPR1), a G protein-coupled receptor to mediate the chemoattraction of macrophages, phagocytosis, and the inflammatory profile of macrophages. It also interacts with cell surface neurexin to mediate signalling across the synapse. Further understanding the mechanisms by which this conserved protein family regulates diverse biological processes such as in neuronal functions, inflammation, and tissue fibrosis will help to design therapeutic targets for the treatment of TAFA related diseases such as spinal cord injury and neuro-inflammatory disorders.
Research Priorities on One Health: A Bibliometric Analysis

Objective One Health is an emerging research area that has received increasing attention globally. In this study, we aimed to explore the global research trend and hotspots of One Health and provide a reference for potential future research and practices. Methods This was a bibliometric descriptive study of publications on One Health in four directions, including zoonotic diseases, antimicrobial resistance, food safety, and vector-borne infections. Publications from 2003 to 2021 were retrieved using the Scopus database on One Health, which were screened based on the PRISMA guidelines. Keywords were analyzed and visualized using VOSviewer software. Results A total of 12,815 publications were included. The annual number of publications and those on each topic showed a gradual increase from 181 in 2003 to 1,647 in 2020, with an average annual growth rate of about 20.2%; the top three countries in terms of the number of publications were the United States of America (n=3,588), the United Kingdom (n=1,429) and China (n=1,233); the major research subjects were mainly in the natural sciences, with fewer social sciences subjects involved (n = 312; 1%). The main research directions within the area of zoonotic diseases included viral, bacterial, parasitic zoonotic diseases, and vector-borne diseases, with a small amount of antimicrobial resistance research. The major research interests within antimicrobial resistance were Enterobacteriaceae drug-resistant bacteria, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, and antimicrobial resistance gene detection; research on food safety clustered around agronomy research, aquaculture research as well as a small amount of antimicrobial resistance research in food; and research on vector-borne diseases focused on mosquito-borne infectious diseases, tick-borne infectious diseases, and vectors. Conclusions The scientific literature on One Health has witnessed a rising global trend. Most research has focused on the human-animal health interface, while environmental health is often neglected. Research subjects mainly fall within natural science disciplines, with less social science research. More support needs to be given to interdisciplinary and intersectoral cooperation and research in the future.
Evaluation of the Community-Based Hypertension Management Programs in China

Purpose The National Essential Public Health Services Package (NEPHSP), a set of community-based hypertension management programs, was launched by the Chinese government in 2009. However, the data are limited for the comprehensive evaluation of NEPHSP on hypertension management. This study was to estimate the effect of NEPHSP on hypertension control nationwide in China. Methods Data were from China Hypertension Survey (CHS). The participants (n = 119,412) aged ≥35 years with hypertension were included in the analysis. Further, a subset of 64,188 diagnosed hypertensive patients were analyzed to evaluate the effect of NEPHSP by comparing the ones covered and not covered by NEPHSP. Blood pressure (BP) was measured by trained staff using a validated digital portable monitor in local communities or clinics. Results Among adults aged ≥35 years with hypertension, the coverage of NEPHSP was 25.6% and increased with age. The coverage was significantly higher in women than in men (P < 0.001). Among the 64, 188 diagnosed hypertensive patients, compared to the control group (not covered by NEPHSP), the mean systolic and diastolic BPs were 2 mmHg and 1.6 mmHg lower in NEPHSP group, respectively. The rate of treatment for hypertension was significantly higher in NEPHSP group than the control group (93.0% vs. 81.4%, P < 0.001), and the rate of BP control was also significantly higher in NEPHSP group than the control group (35.9% vs. 29.6%, P < 0.001). Furthermore, similar trends were found in rural and urban, as well as in men and women. Conclusions Our results showed that NEPHSP is effective in improving hypertension treatment and control in hypertensive patients in China. However, the coverage of NEPHSP was still low.
Predictive Nomogram for Clinical Prognosis in Cervical Spondylotic Myelopathy With Intramedullary T2-Weighted Increased Signal Intensity: A Novel Digital Tool for Patient Prognosis Education

Aims To establish a predictive nomogram for clinical prognosis in cervical spondylotic myelopathy (CSM) with intramedullary T2-weighted increased signal intensity (ISI). Methods The clinical data of 680 patients with CSM with intramedullary T2-weighted ISI were retrospectively analyzed. The patients were divided into the modeling group (476) and the validation group (204) by using a random number table at a ratio of 7:3. The independent prognostic factors were screened using multivariate logistic regression analysis. The factors were subsequently incorporated into the establishment of the predictive nomogram. The area under the receiver operating characteristic (ROC) curve (AUC) was undertaken to estimate the discrimination of the predictive nomogram. The calibration curve and the Hosmer-Lemeshow test were used to assess the calibration of the predictive nomogram. The clinical usefulness of the predictive nomogram was evaluated by decision curve analysis (DCA). Results Based on the pre-operative Japanese Orthopedic Association (JOA) score, maximal canal compromise (MCC), and maximal spinal cord compression (MSCC), we established a predictive nomogram. The AUCs in the modeling group and validation group were 0.892 (95% CI: 0.861~0.924) and 0.885 (95% CI: 0.835~0.936), respectively, suggesting good discrimination of the nomogram. Calibration curves showed a favorable consistency between the predicted probability and the actual probability. In addition, the values of P of the Hosmer-Lemeshow were 0.253 and 0.184, respectively, suggesting good calibration of the nomogram. DCA demonstrated that the nomogram had good clinical usefulness. Conclusion We established and validated a predictive nomogram for the clinical prognosis in CSM with intramedullary T2-weighted ISI. This predictive nomogram could help clinicians and patients identify high-risk patients and educate them about prognosis, thereby improving the prognosis of high-risk patients.
The Beneficial Role of Probiotic Lactobacillus in Respiratory Diseases

Respiratory diseases cause a high incidence and mortality worldwide. As a natural immunobiotic, Lactobacillus has excellent immunomodulatory ability. Administration of some Lactobacillus species can alleviate the symptoms of respiratory diseases such as respiratory tract infections, asthma, lung cancer and cystic fibrosis in animal studies and clinical trials. The beneficial effect of Lactobacillus on the respiratory tract is strain dependent. Moreover, the efficacy of Lactobacillus may be affected by many factors, such as bacteria dose, timing and host background. Here, we summarized the beneficial effect of administered Lactobacillus on common respiratory diseases with a focus on the mechanism and safety of Lactobacillus in regulating respiratory immunity.
23-58 Karin Olesen.pmd

This paper explores the extent to which the adoption of the 2006 Accounting Standards for Business Enterprises (ASBE) in China has resulted in a closer alignment of the Chinese Generally Accepted Accounting Practices (GAAP) with the International Financial Reporting Standards (IFRS). We examine the annual reports of forty seven (47) companies listed on the Shanghai and Shenzhen Stock Exchanges over a two year period between 2006 and 2007. We find that the gap in the profit and equity values between the IFRS and the Chinese GAAP shrunk in absolute terms and that differences between the two sets of accounts disappear following the introduction of the ASBE 2006. In addition, we examine the source of the continued differences between the IFRS and the Chinese GAAP values following the introduction of the 2006 ASBE. The results show that the differences still exist in respect of treatments of financial assets and liabilities, revaluation and depreciation of financial assets, business combinations and land use rights, because even though the companies employed the fair value method in their IFRS accounts, they chose to implement cost method for their accounts prepared under the Chinese GAAP. Our results show that the alignment of standards through convergence has not caused an alignment of practices.
Developing a framework for an ecosystem-based approach to sustainable marina development: Including a framework application case study for a marina on the island of Mauritius, Indian Ocean

This thesis report considers the topic of sustainable marina development. This term can be understood to be a combination of two terms; “sustainable development” and “marina”. Sustainable development in this research study has been considered in relation to the coastal zone and basically entails an approach to ensure a balance between the environment and economic development. A marina, being a coastal (economic) development, interacts with the environmental conditions of the coastal zone and as such, affects the balance for sustainable development. Sustainable marina development is subsequently defined as the development of a marina in such a way and capacity, that the marina integrates its natural, social and economic environment. Additionally, a marina cannot be deemed sustainable by itself, as important principles for sustainable development like the cumulative impacts, multiple (long-term) objectives and sustainability need to be considered on the level of the larger coastal zone, or ecosystem. Currently, marina design is considered to lack an integrated development approach, and is inadequately represented in current marina development guidelines. Especially the initial stages of marina development, involving important development considerations like location selection and alternatives evaluation, lack the assessment of a marina’s integration in its natural, social and economic environment; a key element of sustainable development.
Microbial Fuel Cells and Parameters Affecting Performance When Generating Electricity

The need for a less costly source of energy and wastewater treatment has been greatly increasing in developing countries. The novel technology of micro-bial fuel cells has provided the solution for this problem, but in small scale experiments. This technology uses microorganism to convert bioelectro-chemical compounds to electrical energy. Power out-put produced by different MFC varies. However, ad-vanced knowledge and understanding of the para-meters facing the performance of MFC will be a break through for this technology, therefore making it ready for commercial use.
Sensitivity of Liquefaction Triggering Analysis to Earthquake Magnitude

Application of liquefaction triggering analysis with design ground motions derived from a probabilistic seismic hazard analysis (PSHA), as in AS1170.4 (2007) or most modern seismic codes, requires selection of an appropriate design earthquake magnitude. Guidance on selection of appropriate design earthquake magnitudes is often directed by the seismic code as the maximum considered earthquake (ASCE 7-10) or from a magnitude distance deaggregation (CalTrans 2012). Where guidance is lacking the selection process is based on professional judgment. This paper explores the sensitivity of selection of earthquake design magnitude to liquefaction triggering factor of safety in the context of liquefaction assessments in Australia following AS1170.4 (2007) where guidelines for design earthquake magnitudes for liquefaction are not specified. The assessment shows that following the simplified liquefaction trigger analysis methodology (Seed and Idriss, 1971) very loose to loose saturated sands, would liquefy regardless of the design magnitude selected and high importance sites on medium dense saturated sands would also liquefy regardless of the design magnitude selected. The assessment also shows that liquefaction triggering analysis is very sensitive to the design magnitude selected for normal importance sites on loose to medium dense sands.
Effective Human Activity Recognition Approach using Machine Learning

— The growing development in the sensory implementation has facilitated that the human activity can be used either as a tool for remote control of the device or as a tool for sophisticated human behaviour analysis. With the aid of the skeleton of the human action input image, the proposed system implements a basic but novel process that can only recognize the significant joints. A template for an activity recognition system is provided in which the reliability of the process of recognition and system quality is preserved with a good balance. The research presents a condensed method of extraction of features from spatial and temporal features of event feeds that are further subject to the mechanism of machine learning to improve the performance of recognition. The criticalness of the proposed study is reflected in the outcomes, which when trained using KNN, show higher accuracy performance. The proposed system demonstrated 10-15% of memory usage over 532 MB of digitized real-time event information with 0.5341 seconds of processing time consumption. Therefore on a practical basis, the supportability of the proposed system is higher. The outcomes are the same for both real-time object flexibility captures and static frames as well.
The U.S. Coast Guard 87’ Patrol Boat Maintenance Program: An Analysis of a Scheduling and Resource Leveling Problem

The U.S. Coast Guard 87’ Patrol Boat Maintenance Program: An Analysis of a Scheduling and Resource Leveling Problem Amanda DiPietro Chair of the Supervisory Committee: Professor Emeritus Richard Storch Industrial and Systems Engineering Planning and managing military ship repair projects require a delicate balance between softwarebased scheduling, resource loading, and risk mitigation strategies. The U.S. Coast Guard Industrial Yard, through use of Oracle’s Primavera software, has historically used the Critical Path Method (CPM) of scheduling for their maintenance projects. With the introduction of an assembly line program to repair all East Coast 87-foot Patrol Boats named the Bow to Stern Program, the Yard resorted to manually sequencing work items using a Work Breakdown Structure. In this paper, spreadsheet modeling is used as an inexpensive and available tool to study concurrent project loading and the benefits of level loading job shops. The results show imminent program challenges with a compressed project timeline and shared resources throughout the shipyard. A decision tree for schedule risk mitigation strategies and a prioritized list of efficiency improvements are created, highlighting the need for labor fatigue studies and an Integrated Master Plan for overall organizational success.
Tools for Project Management, Workshops and Consulting: A Must-Have Compendium of Essential Tools and Techniques

Typically today's tasks in management and consulting include project management, running workshops and strategic work – all complex activities, which require a multitude of skills and competencies. This standard work, which is also well accepted amongst consultants, gives you a reference or cookbook–style access to the most important tools, including a rating of each tool in terms of applicability, ease of use and effectiveness.
Decline in surface urban heat island intensity in India during heatwaves

Heatwaves cause human mortality around the world and are projected to rise in the future. Despite the in ﬂ uence of urban heat island ( UHI ) on heatwaves, the role of UHI on heatwave intensi ﬁ cation in urban areas in India remains unrecognized. Here using in situ , satellite observations, and model simulations, we show that urban areas in India do not intensify heatwaves. The frequency of hot-days has signi ﬁ cantly ( p-value < 0.05 ) increased in urban areas during 1951 – 2016. The frequency of hot-nights has also increased in the majority of urban areas in India except those located in Indo-Gangetic Plain ( IGP ) . We show that a decline in the frequency of hot-nights ( − 4.5  ±  1.6 hot-nights ) in IGP during 1951 – 2016 is mainly due to intensive irrigation in the region. We con ﬁ rm the in ﬂ uence of irrigation on land surface temperature ( LST ) over IGP using simulations from Community Land Model ( CLM4 ) . Our results show that Surface Urban Heat Island ( SUHI ) intensity in major urban areas in India declines during heatwaves both during the day ( − 0.3  ±  0.7 ° C ) and night ( − 0.3  ±  0.4 ° C ) from the reference SUHIs. Surrounding non-urban areas ( 44.5  ±  5.5 ° C ) are warmer than urban areas ( 43.7  ±  6.8 ° C ) during heatwaves due to the absence of vegetation. Our results