Miracle-dz/UniFAR-FTUs huggingface dataset:
Metabolomic Strategy to Characterize the Profile of Secondary Metabolites in Aspergillus aculeatus DL1011 Regulated by Chemical Epigenetic Agents

Chemical epigenetic regulation (CER) is an effective method to activate the silent pathway of fungal secondary metabolite synthesis. However, conventional methods for CER study are laborious and time-consuming. In the meantime, the overall profile of the secondary metabolites in the fungi treated by the CER reagent is not well characterized. In this study, suberohydroxamic acid (SBHA), a histone deacetylase inhibitor, was added to a culture of Aspergillus aculeatus DL1011 and a new strategy based on LC-MS/MS analysis integrated with various metabolomic tools (MetaboAnalyst, MS-DIAL, SIRIUS and GNPS) was developed to characterize the profile of induced metabolites. As a result, 13.6%, 29.5% and 27.2% of metabolites were identified as newly biosynthesized, increasing and decreasing in abundance by CER, respectively. The structures of the 18 newly induced secondary metabolites were further identified by the new strategy to demonstrate that 72.2% of them (1 novel compound and 12 known compounds) were first discovered in A. aculeatus upon SBHA treatment. The accuracy of the new approach was confirmed by purification and NMR data analysis of major newly biosynthesized secondary metabolites. The bioassay showed that the newly biosynthesized compounds, roseopurpurin analogues, showed selective activities against DPPH scavenging, cytotoxicity and SHP1 inhibition. Our research demonstrated that CER was beneficial for changing the secondary metabolic profile of fungi and was an effective means of increasing the diversity of active metabolites. Our work also supplied a metabolomic strategy to characterize the profile changes and determine the newly induced compounds in the secondary metabolites of fungi treated with the chemical epigenetic regulator.
SCALING OF THE HYDROELASTIC RESPONSE OF FLEXIBLE LIFTING BODIES IN TRANSITIONAL AND TURBULENT FLOWS

The objective of this research is to derive and validate scaling relationships for flexible lifting bodies in transitional and turbulent flows. The motivation is to help the design and interpretation of reduced-scale experimental studies of flexible hydrofoils, with focus on the influence of viscous effects on the hydroelastic response. The numerical method is based on a previous validated viscous FSI solver presented in [1]. It is based on the coupling between a commercial Computational Fluid Dynamics (CFD) solver, CFX, and a simple two-degrees-of-freedom (2-DOF) system that simulates the free tip section displacement of a cantilevered, rectangular hydrofoil. To validate the scaling relations, sample numerical results are shown for three geometrically similar models: full scale, 1/2 scale and 1/10 scale. On the fluid side, although the effects of gravity and compressibility are assumed to be negligible, three different methods of scaling the velocity are considered: Reynolds scaling, Froude scaling, and Mach scaling. The three scaling methods produce different velocity scales when the fluid properties and gravitational constant are the same between the model and prototype, which will lead to different scaling for the material properties. The results suggest that by applying Mach scaling (which does not mean the flow is compressible, but simply requires the relative inflow velocity and fluid properties to be the same between the model and the prototype) and Re ≥ 2 × 106, the same material as the full scale could be used, which will lead to similar stress distributions, in addition to similar strains, and hence similar hydroelastic response and failure mechanisms. However, if Re ≤ 2 × 106 and Mach scale is used, a viscous correction is required to properly extrapolate the experimental results to full-scale.Copyright © 2013 by ASME
Mating Competitiveness of Irradiated Lobesia botrana (Lepidoptera: Tortricidae) in Male-Only and Both Sex Release Strategies under Laboratory Cage Conditions

Simple Summary The sterile insect technique/inherited sterility (SIT/IS) has been successfully implemented to suppress or eradicate pestiferous species of Lepidoptera. The SIT/IS involves the release of mass-reared and gamma-irradiated moths (partially sterile males and fully sterile females) to achieve matings with wild moths. The success of any SIT/IS project depends, inter alia, on the overflooding ratio of released sterile moths to wild moths and the efficiency of male-only versus bi-sex releases of irradiated moths. The current laboratory study aims to understand the efficacy of overflooding ratios and the use of male-only releases compared with bi-sex releases for SIT/IS against the European grapevine moth, Lobesia botrana (Denis and Schiffermüller). Abstract This laboratory study explored the concept of whether irradiated male-only releases are more or equally efficient as releases of both irradiated males and females in the context of using the sterile insect technique/inherited sterility (SIT/IS) for the management of the European grapevine moth Lobesia botrana. The current study examined the mating competitiveness of 150-Gy-treated L. botrana male and female moths or 150-Gy-treated male moths only, with untreated moths in laboratory cages. Our results showed that the release of both sexes significantly increased the competitiveness value (C) and the biological efficiency index (BE) as compared with male-only release, and this was independent of the male to untreated male ratio. Moreover, a single release of 150-Gy-treated and untreated males and females at a 1:1:10:10 ratio (untreated male:untreated female: treated male:treated female) significantly reduced egg hatch, and the number of first-generation offspring (F1) was small. The emergence of F2-moths per untreated F1 male and female moth was low, but these undesired fertile moths should be eliminated in order to achieve effective control. The results presented herein provide useful information on the impact of 150-Gy-treated male-only, versus releases of both treated males and females on untreated moths, which is essential to managing L. botrana populations with SIT/IS.
Alfvén waves from an electrodynamic tethered satellite system

The operation of an electrodynamic tethered satellite system in the ionosphere in a steady state (constant current) mode is intimately connected with the electromagnetic plasma waves the system excites, since these waves carry the electrical currents that complete the tethered system/plasma circuit. The analysis reported here determines (within cold plasma theory) the ionospheric currents and associated wave impedance based on a tethered system current distribution that takes into account the “dumbbell” geometry of the system. The analysis is not restricted to terminating satellite dimensions that are much greater than the system's velocity divided by the ion cyclotron frequency, as as been the case in almost all previous studies of the problem. When this condition is not satisfied, the “Alfven wings” (field line sheet currents) are found to be wider than the dimensions of the terminating satellite, a result of the wave nature of the phenomenon and restrictions on perpendicular wavelengths along the line-of-flight direction. Previously reported large wave impedances associated with an orbiting wire, which would limit tether currents to low values, are shown to be inapplicable to a more realistic model of the tethered system. The calculated wave impedance, which depends weakly on the system dimensions, is only a few ohms or less in low Earth orbit.
Fingering Instabilities of Driven Spreading Films

We show that a thin film with small dynamic contact angle and driven by an external body force is unstable to the formation of fingers in the direction perpendicular to the main flow. The instability is largest in the capillary region near the contact line, where the force due to surface tension is comparable to the viscous and gravitational forces. The fastest growing wavelength is calculated in the limit of small-amplitude disturbances. These instabilities may be related to finger patterns observed in gravitational flows and spinning drops.
A Diagnostic Model for Estimating Large-Scale Flow Patterns in the Tropical Upper Troposphere from Satellite Cloud Brightness Data

Abstract A diagnostic model is proposed to use digitized satellite cloud brightness data to estimate objectively the large-scale flow patterns over data-void tropical regions. The model utilizes a linear barotropic vorticity equation with two primary assumptions: 1) that the area-averaged cloud brightness is positively correlated with large-scale divergence in the tropical upper troposphere; and 2) that the large-scale tropical flow is quasi-barotropic and quasi-non-divergent. It is designed to be used at any upper tropospheric level where divergence is important in determining the vorticity field. Three types of information are required: 1) boundary conditions determined from surrounding wind reports, 2) a mean zonal flow determined from climatology, and 3) an equivalent divergence forcing function constructed empirically from the brightness data. The model is tested daily over a western North Pacific region for July-August 1971. Results for an 8-day representative period are presented and discussed. In .
The COVID-19 Pandemic and Factors Influencing the Destination Choice of International Visitors to Vietnam

The Association of Southeast Asian Nations (ASEAN) is an attractive tourist destination with diverse and unique experiences, in which Vietnam is considered one of the most famous destinations in this region. Quality evaluations and strategies for attracting international tourists are being thoroughly researched. However, the COVID-19 pandemic has had the most significant impact on the tourism industry, which has suffered greatly. Therefore, the recovery and expansion of international tourism necessitate the employment of tourism-related businesses and service sector workers. Extensive research must be conducted to identify solutions and new directions to recover the international tourist market’s growth as quickly as possible. This study identifies the factors that influence the destination of international visitors visiting Vietnam after the COVID-19 pandemic by modifying and evaluating the scales of the theoretical model. Using the convenience sampling technique, data were collected through interviews with 208 international visitors, with 29 observed variables. Using SPSS 22.0, five factors influencing international visitors’ decisions to visit Vietnam were revealed: tourist motivation, tourist attitude, destination image, social media, and environmental quality. Finally, the authors provide policy recommendations to enhance the allure and viability of Vietnam’s tourism following the effects of the COVID-19 pandemic. This study’s outcome is intended to establish the importance of the many variables influencing the choice of destination for international visitors.
GEOMETRICAL FRUSTRATION IN THE FERROMAGNETIC PYROCHLORE HO2TI2O7

We report a detailed study of the pyrochlore Ho{sub 2}Ti{sub 2}O{sub 7}, in which the magnetic ions (Ho{sup 3+}) are ferromagnetically coupled with J{approximately}1 K . We show that the presence of local Ising anisotropy leads to a geometrically frustrated ground state, preventing long-range magnetic order down to at least 0.05K. However, unlike in the case of a frustrated {ital antiferromagnet,} this disorder is principally static. In a magnetic field, the ground-state degeneracy is broken and ordered magnetic phases are formed which display an unusual history dependence due to the slow dynamics of the system. These results represent the first experimental evidence for geometrical frustration in a {ital ferromagnetic} system. {copyright} {ital 1997} {ital The American Physical Society}
Infrared metamaterials and plasmons engineering

Metamaterials in infrared and optical domain are mainly based on metal-dielectric composite. Collective excitations also called surface plasmons are thus the main mechanism in infrared metamaterials structures. Taking profit of the plasmonic interpretation instead of LC circuit approaches (better suited for microwave experiment) new approaches in understanding and engineering resonances is possible. In this paper we show numerically and experimentally how certain metamaterials can open opportunities in the engineering of plasmonic modes at the nanoscale for application including sensing and SERS (surface enhanced Raman Spectroscopy).
Behaviors of InGaZnO thin film transistor under illuminated positive gate-bias stress

In this letter, we investigate the impact of the light illumination on the stability of indium–gallium– zinc oxide thin film transistors under positive gate-bias stress. The noticeable decrease in threshold voltage Vt shift more than 5.5 V under illuminated positive gate-bias stress indicates a superior reliability in contrast with the dark stress. The accelerated Vt recovery characteristic compared with dark recovery demonstrates that the charge detrapping effect was enhanced under illumination. Furthermore, the average effective energy barrier of charge trapping and detrapping was derived to verify that illumination can excite the trapped charges and accelerate the charge detrapping process. © 2010 American Institute of Physics. doi:10.1063/1.3481676
Time reversal of continuous-wave, steady-state signals in elastic media

Experimental observations of spatial focusing of continuous-wave, steady-state elastic waves in a reverberant elastic cavity using time reversal are reported here. Spatially localized focusing is achieved when multiple channels are employed, while a single channel does not yield such focusing. The amplitude of the energy at the focal location increases as the square of the number of channels used, while the amplitude elsewhere in the medium increases proportionally with the number of channels used. The observation is important in the context of imaging in solid laboratory samples as well as problems involving continuous-wave signals in Earth.
The autostrada queueing problem

The model considered in this note has been referred to by Haight (1958), Kingman (1961) and Flatto and McKean (1977) as two queues in parallel. Customers choose the shorter of the two queues which are otherwise independent. This system is known to be inferior to a single queue feeding the two servers, but how much? Some elementary considerations provide a fresh perspective on this awkward boundary-value problem. A procedure is proposed for the solution in the context of finite waiting-room size and some comparisons are made with the single-queue system and an independent two-queue system.
Refined Carbon Emission Measurement Based on NPP-VIIRS Nighttime Light Data: A Case Study of the Pearl River Delta Region, China

The accurate measurement of CO2 emissions is helpful for realizing the goals of “carbon neutralization” and “carbon peak”. However, most current research on CO2 emission measurements utilizes the traditional energy balance coefficient and top-down methods. The data granularity is large, and most studies are concentrated at the national, provincial, municipal, or district/county administrative unit scale. As an important part of the Guangdong–Hong Kong–Macao Greater Bay Area of China, the Pearl River Delta region has good nighttime light vitality and faces huge carbon emission pressure. Using the Pearl River Delta as the research area, this study constructed an optimized pixel-scale regression model based on NPP-VIIRS (The Visible Infrared Imaging Radiometer Suite on the Suomi National Polar-Orbiting Partnership spacecraft) nighttime light data and CO2 emissions data at the district and county levels for 2017. In addition, the spatial pattern of CO2 emissions in the Pearl River Delta was analyzed based on the predicted CO2 emission status. The results showed that the spatial pattern of CO2 emissions in the Pearl River Delta had the distinct characteristics of the “center-edge” effect, the spatial spillover effect, and high-value aggregation, which should be considered when making related social or public decisions.
Characteristics of patients with meningitis after lumbar epidural steroid injection

To investigate the clinical, laboratory, and radiological features of meningitis after lumbar epidural steroid injection (M-ESI) without accompanying spinal infection, data of patients with meningitis admitted between January 2014 and December 2021 in a single center were retrospectively reviewed. Among them, patients with a recent history of lumbar ESI were identified, and their medical records were collected. Patients with concomitant infections other than meningitis, including spinal epidural abscess, were excluded. Seven patients with M-ESI were identified. All patients presented with headache and fever without focal neurological deficits, and headache developed shortly after a procedure (median, 4 hours). Cerebrospinal fluid (CSF) analysis showed neutrophilic pleocytosis (median, 6729/μL), elevated protein level (median, 379.1 mg/dL), decreased ratio of CSF glucose to serum glucose (median, 0.29), and elevated lactate level (median, 8.64 mmol/L). Serum level of C-reactive protein was elevated in 6, but serum procalcitonin level was within normal range. No causative pathogen was identified in the microbiological studies. The most frequent radiologic feature was sulcal hyperintensity on fluid-attenuated inversion recovery images (57%), followed by pneumocephalus (43%). Symptoms subsided in a short period (median, 1 day) after initiating treatment with antibiotics and adjuvant intravenous corticosteroids. None of the patients experienced neurological sequelae. Though the cardinal symptoms and CSF findings of M-ESI were comparable to those of bacterial meningitis, M-ESI seems to have distinctive characteristics regarding the clinical course, laboratory parameters, and pneumocephalus.
Non-destructive permittivity measurement of solid materials

An open-coaxial probe suitable for measuring the permittivity of solid materials has been designed and tested. The peculiar structure of the probe allows an easy and firm contact with the surface of the material under measurement, resulting in highly reliable and reproducible dielectric measurements. The permittivity measurement is absolute, as the calibration procedure - based on a genetic algorithm - does not require the use of dielectric standards. The measurement system - including the probe, a network analyser, and the numerical code to determine the permittivity from reflection measurements - have been tested on solid materials of known properties, and used for determining the dielectric characteristics of several types of wood.
Przemiany demograficzne wybranych terenów przemysłowych i poprzemysłowych we Wrocławiu w XXI wieku

W pracy przedstawiono zmiany demograficzne zachodzące na wybranych terenach przemysłowych i poprzemysłowych dużego miasta, jakim jest Wrocław w XXI w. Ponadto w artykule zostały zasygnalizowane towarzyszące tym metamorfozom przemiany badanych terenów przemysłowych i poprzemysłowych: morfologiczno-fizjonomiczne oraz funkcjonalne. Studia opierały się na analizie danych z bazy PESEL, kwerendzie archiwalnej i kartograficznej oraz badaniach terenowych. Badane miejsca w XXI w. uległy istotnym przeobrażeniom, które w znacznej mierze były determinowane procesem deglomeracji działalności przemysłowej z centrów dużych miast oraz chęcią zintensyfikowania użytkowania przestrzeni atrakcyjnie zlokalizowanej wewnątrz tkanki dużego miasta. Największy wpływ na modyfikację badanej przestrzeni miały firmy prowadzące działalność deweloperską oraz usługową.
A Subtlety of Sizing the Inset Gap Width of a Microstrip Antenna When Built on an Ultra-Thin Substrate in the S-Band

In this paper, Pyralux—a modern, ultra-thin, and acrylic-based laminate—was tested as a substrate of a microstrip antenna to examine the antenna characteristics when it is built on such a thin, flexible, and robust dielectric material, with the idea of eventually serving in wearable antennas in the context of smart-clothing applications. We particularly discuss the sensitivity of the design and fabrication of an inset-fed rectangular microstrip antenna (IRMA) in terms of its inset gap width when it is designed in the S-frequency band. The simulated and measured results showed a very small feasible range for the inset gap dimension with respect to the feed line width. Ultimately, an IRMA was successfully designed, fabricated, and tested with both SMA and U.FL connectors. The impedance bandwidth, in either case, was about 2%, the average value of directivity was 5.8 dB, and the realized efficiency was 2.67%, while the 3-dB beamwidths in the E-plane and the H-plane were 90° or wider.
The Relationship between Binge Drinking and Binge Eating in Adolescence and Youth: A Systematic Review and Meta-Analysis

Adolescence and youth are critical periods in which alcohol consumption is usually initiated, especially in the form of binge drinking. In recent years, it is increasingly common to find adolescents and young people who also present binge behaviors towards unhealthy food with the aim of alleviating their anxiety (emotional eating) and/or because of impulsive personality. Despite the social and health relevance of this issue, it remains scarcely studied and more preventive research needs to be developed. Our meta-analysis study aimed to evaluate the relationship and co-occurrence of both binge behaviors during adolescence and young adulthood to clarify the link between binge drinking and eating. Selective literature search on different online databases was performed. We identified discrete but significant results regarding the direct association between binge drinking and binge eating in correlation coefficients and odds ratio. Future research should focus on the common psychological background and motives behind these problematic behaviors owing to their clinical implications for effective prevention and treatment.
SurA-like and Skp-like Proteins as Important Virulence Determinants of the Gram Negative Bacterial Pathogens

In the Gram-negative bacteria, many important virulence factors reach their destination via two-step export systems, and they must traverse the periplasmic space before reaching the outer membrane. Since these proteins must be maintained in a structure competent for transport into or across the membrane, they frequently require the assistance of chaperones. Based on the results obtained for the model bacterium Escherichia coli and related species, it is assumed that in the biogenesis of the outer membrane proteins and the periplasmic transit of secretory proteins, the SurA peptidyl–prolyl isomerase/chaperone plays a leading role, while the Skp chaperone is rather of secondary importance. However, detailed studies carried out on several other Gram-negative pathogens indicate that the importance of individual chaperones in the folding and transport processes depends on the properties of client proteins and is species-specific. Taking into account the importance of SurA functions in bacterial virulence and severity of phenotypes due to surA mutations, this folding factor is considered as a putative therapeutic target to combat microbial infections. In this review, we present recent findings regarding SurA and Skp proteins: their mechanisms of action, involvement in processes related to virulence, and perspectives to use them as therapeutic targets.
Simple Latin Square Sampling ± k Designs

Abstract If spatial correlation is present, sampling designs which ensure the sample is well-distributed over the study region will, in general, improve estimation of population abundance relative to designs that do not. Simple latin square sampling ±k designs, a new class of probability sampling designs that were developed for this situation, will be presented. When the goal is estimation of the population total or mean, these designs when compared to simple random, stratified, and systematic sampling will, in general, provide estimators with smaller variance when spatial correlation is present.