Miracle-dz/UniFAR-FTUs huggingface dataset:
Broadband spectral modelling of bent jets of Active Galactic Nuclei

In this thesis, models have been developed to study the radiation emission processes from the knots of AGN jets as well as for blazar jets. A continuous injection plasma model is developed to study the X-ray emission from the knots of sources 1136-135, 1150+497, 1354+195 and 3C 371. The knot dynamics is then studied within the framework of internal shock model. In such a scenario, knots are formed due to the collision of two successive matter blobs emitted sporadically from the central engine of AGN. Shocks, generated in such collisions, accelerate electrons to relativistic energies. These electrons subsequently emit radiation via synchrotron and/or inverse Compton processes in the radio-to-X-ray energy range. The study of M87 knots involves a two zone model where the electrons with a power-law distribution are further accelerated. The synchrotron emission from these energetic electrons is then used to explain the observed spectrum. The limb-brightening feature observed in the radio maps of the BL Lac object MKN501 is studied considering shear acceleration of electrons at the boundary of the jet. This interpretation does not require a large viewing angle of the jet as demanded by the earlier models and is consistent with the constraints obtained from very high energy studies. In case of MKN421, the dependence of temporal behaviour of radiation emission on the particle acceleration mechanism has been studied within the framework of two zone model.
The cosmic web and the orientation of angular momenta

We use a 64 h−1 Mpc dark-matter-only cosmological simulation to examine the large-scale orientation of haloes and substructures with respect to the cosmic web. A web classification scheme based on the velocity shear tensor is used to assign to each halo in the simulation a web type: knot, filament, sheet or void. Using ∼106 haloes that span ∼3 orders of magnitude in mass, the orientation of the halo’s spin and the orbital angular momentum of subhaloes with respect to the eigenvectors of the shear tensor is examined. We find that the orbital angular momentum of subhaloes tends to align with the intermediate eigenvector of the velocity shear tensor for all haloes in knots, filaments and sheets. This result indicates that the kinematics of substructures located deep within the virialized regions of a halo is determined by its infall which in turn is determined by the large-scale velocity shear, a surprising result given the virialized nature of haloes. The non-random nature of subhalo accretion is thus imprinted on the angular momentum measured at z= 0. We also find that the haloes’ spin axis is aligned with the third eigenvector of the velocity shear tensor in filaments and sheets: the halo spin axis points along filaments and lies in the plane of cosmic sheets.
City-scale assessment of long-term air quality impacts on the respiratory and cardiovascular health

Background The impact of the urban environment on human health is a contemporary subject of environmental research. Air pollution is often considered a leading environmental driver. However, a plethora of other factors within the urban exposome may be involved. At the same time, the resolution of spatial data is also an important facet to consider. Generally, systematic tools for accurate health risk assessment in the urban environment are missing or are not implemented. Methods The long-term impact of air quality (PM10, PM2.5, NO2, benzene, and SO2) on respiratory and cardiovascular health was assessed with a log-linear model. We used the most accurate health data in high city scale spatial resolution over the period 2010 to 2018. Selected external exposome parameters were also included in the analysis. Results Statistically significant associations between air pollution and the health of the urban population were found. The strongest association was between benzene and the incidence of bronchitis in the adult population [RR 1.552 95% CI (1.415–1.704) per 0.5 μg/m3 change in benzene concentration]. A similar relation was observed between NO2 and the same health condition [RR 1.483 95% CI (1.227–1.792) per 8.9 μg/m3 of change in NO2]. Other weaker associations were also found between asthma in children and PMs, NO2, or benzene. Cardiovascular-related hospitalizations in the general population were linked with NO2 [RR 1.218 95% CI (1.119–1.325) per 9.7 μg/m3 change in NO2]. The remaining pollutants were slightly less but still significantly associated with cardiovascular-related hospitalizations. Conclusion Our findings are mostly highly statistically significant (p ≤ 0.001) and are in line with current literature on the adverse effects of air pollution on the human population. The results highlight the need for continual improvements in air quality. We propose the implementation of this approach as a systematic tool for the investigation of possible health risks over a long period of time. However, further research involving other variables is an essential step toward understanding the complex urban exposome and its implications for human health. An increase in data spatial resolution is especially important in this respect as well as for improving city health risk management.
PROTOSTELLAR OUTFLOW HEATING IN A GROWING MASSIVE PROTOCLUSTER

The dense molecular clump P1 in the infrared dark cloud complex G28.34+0.06 harbors a massive protostellar cluster at its extreme youth. Our previous Submillimeter Array observations revealed several jet-like CO outflows emanating from the protostars, indicative of intense accretion and potential interaction with ambient natal materials. Here, we present the Expanded Very Large Array spectral line observations toward P1 in the NH3 (J,K) = (1,1), (2,2), (3,3) lines, as well as H2O and class I CH3OH masers. Multiple NH3 transitions reveal the heated gas widely spread in the 1 pc clump. The temperature distribution is highly structured; the heated gas is offset from the protostars, and morphologically matches the outflows very well. Hot spots of spatially compact, spectrally broad NH3 (3,3) emission features are also found coincident with the outflows. A weak NH3 (3,3) maser is discovered at the interface between an outflow jet and the ambient gas. These findings suggest that protostellar heating may not be effective in suppressing fragmentation during the formation of massive cores.
A giant radio halo in the low luminosity X-ray cluster Abell 523

Context. Radio halos are extended and diffuse non-thermal radio sources present at the cluster center, not obviously associated with any individual galaxy. A strong correlation has been found between the cluster X-ray luminosity and the halo radio power. Aims. We observe and analyze the diffuse radio emission present in the complex merging structure Abell 523, classified as a low luminosity X-ray cluster, to discuss its properties in the context of the halo total radio power versus X-ray luminosity correlation. Methods. We reduced VLA archive observations at 1.4 GHz to derive a deep radio image of the diffuse emission, and compared radio, optical, and X-ray data. Results. Low-resolution VLA images detect a giant radio halo associated with a complex merging region. The properties of this new halo agree with those of radio halos in general discussed in the literature, but its radio power is about a factor of ten higher than expected on the basis of the cluster X-ray luminosity. Conclusions. Our study of this giant radio source demonstrates that radio halos can also be present in clusters with a low X-ray luminosity. Only a few similar cases have so far been found. This result suggests that this source represents a new class of objects, that cannot be explained by classical radio halo models. We suggest that the particle reacceleration related to merging processes is very efficient and/or the X-ray luminosity is not a good indicator of the past merging activity of a cluster.
Conserved charge of a gravity theory with $p$-form gauge fields and its property under Kaluza-Klein reduction

In this paper, we investigate the conserved charges of generally diffeomorphism invariant gravity theories with a wide variety of matter fields, particularly of the theories with multiple scalar fields and $p$-form potentials, in the context of the off-shell generalized Abbott-Deser-Tekin (ADT) formalism. We first construct a new off-shell ADT current that consists of the terms for the variation of a Killing vector and expressions of the field equations as well as the Lie derivative of a surface term with respect to the Killing vector within the framework of generally diffeomorphism invariant gravity theories involving various matter fields. After deriving the off-shell ADT potential corresponding to this current, we propose a formula of conserved charges for these theories. Next, we derive the off-shell ADT potential associated with the generic Lagrangian that describes a large range of gravity theories with a number of scalar fields and $p$-form potentials. Finally, the properties of the off-shell generalized ADT charges for the theory of Einstein gravity and the gravity theories with a single $p$-form potential are investigated by performing Kaluza-Klein dimensional reduction along a compactified direction. The results indicate that the charge contributed by all the fields in the lower-dimensional theory is equal to that of the higher-dimensional one at mathematical level with the hypothesis that the higher-dimensional spacetime allows for the existence of the compactified dimension. In order to illustrate our calculations, the mass and angular momentum for the five-dimensional rotating Kaluza-Klein black holes are explicitly evaluated as an example.
Application of 5-aminolevulinic acid promotes ripening and accumulation of primary and secondary metabolites in postharvest tomato fruit

5-Aminolevulinic acid (ALA) plays a vital role in promoting plant growth, enhancing stress resistance, and improving fruit yield and quality. In the present study, tomato fruits were harvested at mature green stage and sprayed with 200 mg L–1 ALA on fruit surface. During ripening, the estimation of primary and secondary metabolites, carotenoids, and chlorophyll contents, and the expression levels of key genes involved in their metabolism were carried out. The results showed that ALA significantly promoted carotenoids accumulation by upregulating the gene expression levels of geranylgeranyl diphosphate synthase (GGPPS, encoding geranylgeranyl diphosphate synthase), phytoene synthase 1 (PSY1, encoding phytoene synthase), phytoene desaturase (PDS, encoding phytoene desaturase), and lycopeneβ-cyclase (LCYB, encoding lycopene β-cyclase), whereas chlorophyll content decreased by downregulating the expression levels of Mg-chelatase (CHLH, encoding Mg-chelatase) and protochlorophyllide oxidoreductase (POR, encoding protochlorophyllide oxidoreductase). Besides, the contents of soluble solids, vitamin C, soluble protein, free amino acids, total soluble sugar, organic acid, total phenol, and flavonoid were increased in ALA-treated tomato fruit, but the fruit firmness was decreased. These results indicated that the exogenous ALA could not only promote postharvest tomato fruit ripening but also improve the internal nutritional and flavor quality of tomato fruit.
Engaging patients in balanced scorecard evaluation - An implication at Palestinian hospitals and recommendations for policy makers

Introduction A balanced scorecard (BSC) is a comprehensive performance evaluation (PE) tool. A recent review summarized that a balanced consideration of PE from six perspectives in hospitals must be considered: financial, customer, internal, external, knowledge and growth, and managerial. However, patients were rarely engaged in BSC implementations. This research aims to engage Palestinian patients in BSC implementation to develop recommendations for policy makers. Methodology In this cross-sectional study, the BSC-PATIENT survey was distributed between January and October 2021. We evaluated patients' experiences and their attitudes toward BSC dimensions (BSCP ATT). The differences in evaluations based on admission status were analyzed using the Mann-Whitney U test. Causal relationships between patients' experiences and attitudes were analyzed using multiple linear regression. We tested the multicollinearity of the model. Path analysis was performed to understand the BSC strategic maps based on the Palestinian patients' evaluations. Results Out of 1,000 surveys, 740 were retrieved. The mean scores for Palestinian patient experiences evaluation showed that the services experience factor had the highest score (87.7 ± 17.7), and the patient care experience factor had the lowest score (57 ± 34.5). Patient experiences collectively predicted 56.4% of the variance in the BSCP ATT. The experience factors of information (β = 0.400, t = 13.543, P < 0.001), patient care (β = 0.241, t = 8.061, P < 0.001), services (β = 0.176, t = 6.497, P < 0.001), and building (β = 0.177, t = 6.308, P < 0.001) had the highest impact on BSCP ATT. The price had only a weak negative influence (β = −0.051, t = −2.040, P = 0.042). Accessibility to hospitals did not have any impact on BSCP ATT. Significant differences between inpatient and outpatients' evaluations in regard to experiences related to patient care (P = 0.042), services (P < 0.001), accessibility (P < 0.001), and BSCP ATT (P = 0.003) were found. Conclusion BSC-PATIENT successfully engaged patients in BSC PE at Palestinian hospitals. This research provides strong evidence for the impact of patients' information experience on their attitudes. Palestinian health policy makers must prioritize the design and delivery of patient education programs into their action plans and encourage a two-way information communication with patients. Strong evidence for patient care, services, and building experiences role in improving patients' attitudes was found. Managers should enhance patients' feedback and engagement culture in Palestinian hospitals.
Solid-state optimal phase-covariant quantum cloning machine

Here, we report an experimental realization of optimal phase-covariant quantum cloning machine with a single electron spin in solid state system at room temperature. The involved three states of two logic qubits are encoded physically in three levels of a single electron spin with two Zeeman sub-levels at a nitrogen-vacancy defect center in diamond. The preparation of input state and the phase-covariant quantum cloning transformation is controlled by two independent microwave fields. The average experimental fidelity reaches 85.2% which is very close to theoretical optimal fidelity 85.4% and is beyond the bound 83.3% of universal cloning.
Editorial: Chemical testing using new approach methodologies (NAMs)

In 2007, the U.S. National Research Council (NRC) introduced a novel approach to assure the safety of chemicals based on human-relevant mechanisms of toxicity in their landmark publication “Toxicity Testing in the 21 Century: A Vision and a Strategy” (NRC, 2007). As written by Andersen and Krewski (2009), member and chair of the NRC Committee on Toxicity Testing and Assessment of Environmental Agents, the vision detailed “a not-so-distant future in which virtually all routine testing would be conducted in human cells or lines in vitro”. This Research Topic in Frontiers in Toxicology’s section on “In Vitro Toxicology” is devoted to highlighting research andmethods that continue to advance this vision and to informing readers of the regulatory frameworks where these technologies may be used to inform regulatory filings and decisions. Although no unanimous definition of new approach methodologies (NAMs) exists, NAMs are often defined as any technology,methodology, approach, or combination thereof that can provide information on chemical hazard and risk assessment without the use of animals, including in silico, in chemico, in vitro, and ex vivo approaches (ECHA, 2016; EPA, 2018; Stucki et al.). NAMs are not necessarily newly developed methods, rather, it is their application to regulatory decision making or replacement of a conventional testing requirement that is new. In this Research Topic, we are pleased to present on contributions to NAMs development and go a step further by bridging the science behind NAMs with the regulatory frameworks under which NAMs may be used, and in some cases, the regulatory impediments for their use. Three original research articles on respiratory toxicity provide NAMs for evaluating specific regions of the respiratory tract, such as an adverse outcome pathway (AOP) for impairment of mucociliary clearance in the tracheobronchial region (Luettich et al.) that can be used to design in vitro testing strategies. Sengupta et al. present a lung-on-a-chip with a newly established cell line from epithelial cells from the alveolar regions. Zhang et OPEN ACCESS
A pyroptosis-related gene model and its correlation with the microenvironment of lung adenocarcinoma: A bioinformatics analysis and experimental verification

Background: Non-small cell lung cancer, comprising lung adenocarcinoma (LUAD) and lung squamous cell carcinoma, is one of the leading causes of cancer-related mortality. Pyroptosis is a new form of programmed cell death involved in cancer development. The relationship between LUAD and pyroptosis is unclear. This research aims to investigate this relationship and develop a stratified clinical model based on pyroptosis-related genes (PRGs). Methods: We analyzed the data of LUAD from The Cancer Genome Atlas (TCGA) and evaluated the expression of 48 PRGs to identify the differentially expressed genes. Then, constructing the risk model using the least absolute shrinkage and selection operator and the Cox regression method to find the gene signatures. The functional enrichment, immune cell infiltration, tumor mutational burden (TMB), and expression of immune checkpoints were compared to investigate the potential mechanism. The IC50 of common drugs was evaluated and compared. The inflammasome activation assay and lactate dehydrogenase (LDH) assay of NLR-family CARD-containing protein 4 (NLRC4) were also performed to confirm the role of pyroptosis in LUAD. Results: The pyroptosis-related model accurately predicted the prognosis of patients with LUAD, with the low-risk group exhibiting a higher survival probability. The risk score was an independent prognostic factor for survival. The stratified patients exhibited distinct tumor microenvironments, TMB, and drug sensitivity. The validation experiments of NLRC4 confirmed its role in inducing pyroptosis via promoting IL-1 maturation. Conclusion: PRGs regulated the tumor microenvironment and influenced the outcome of LUAD. NLRC4 may function as a hub gene in the process of LUAD.
MOLECULAR AND IONIZED HYDROGEN IN 30 DORADUS. I. IMAGING OBSERVATIONS

We present the first fully calibrated H2 1–0 S(1) image of the entire 30 Doradus nebula. The observations were conducted using the NOAO Extremely Wide-field Infrared Imager (NEWFIRM) on the CTIO 4 m Blanco Telescope. Together with a NEWFIRM Brγ image of 30 Doradus, our data reveal the morphologies of the warm molecular gas and ionized gas in 30 Doradus. The brightest H2-emitting area, which extends from the northeast to the southwest of R136, is a photodissociation region (PDR) viewed face-on, while many clumps and pillar features located at the outer shells of 30 Doradus are PDRs viewed edge-on. Based on the morphologies of H2, Brγ, CO, and 8 μm emission, the H2 to Brγ line ratio, and Cloudy models, we find that the H2 emission is formed inside the PDRs of 30 Doradus, 2–3 pc to the ionization front of the H ii region, in a relatively low-density environment <104 cm−3. Comparisons with Brγ, 8 μm, and CO emission indicate that H2 emission is due to fluorescence, and provide no evidence for shock excited emission of this line.
Fear conditioning in invertebrates

Learning to identify and predict threats is a basic skill that allows animals to avoid harm. Studies in invertebrates like Aplysia californica, Drosophila melanogaster, and Caenorhabditis elegans have revealed that the basic mechanisms of learning and memory are conserved. We will summarize these studies and highlight the common pathways and mechanisms in invertebrate fear-associated behavioral changes. Fear conditioning studies utilizing electric shock in Aplysia and Drosophila have demonstrated that serotonin or dopamine are typically involved in relaying aversive stimuli, leading to changes in intracellular calcium levels and increased presynaptic neurotransmitter release and short-term changes in behavior. Long-term changes in behavior typically require multiple, spaced trials, and involve changes in gene expression. C. elegans studies have demonstrated these basic aversive learning principles as well; however, fear conditioning has yet to be explicitly demonstrated in this model due to stimulus choice. Because predator–prey relationships can be used to study learned fear in a naturalistic context, this review also summarizes what is known about predator-induced behaviors in these three organisms, and their potential applications for future investigations into fear conditioning.
Gender differences in the subjective well-being of older adult learners in China

The trend of the feminization of the aging population in China is accelerating, and the differences in the subjective well-being of older adults are becoming more and more obvious. This study combines gender theory with gender differences as an entry point, based on 436 survey data, and examines effects and differences between learning engagement on the subjective well-being of older Chinese learners by gender. The study found the following: learning can enhance the subjective well-being of older people; there were significant differences in the subjective well-being of older adult learners by gender in two dimensions, namely, physical and mental health experience and adaptation satisfaction experience; and the positive effect of learning engagement on subjective well-being of female older adults was more pronounced and thus had a stronger effect on their subjective well-being. In addition, the gender equality of older adults’ learning participation and gender differences in learning needs are further explored based on the gender theory perspective, and this gives suggestions for enhancing older adult learners’ subjective well-being.
THE GEOMETRY AND IONIZATION STRUCTURE OF THE WIND IN THE ECLIPSING NOVA-LIKE VARIABLES RW TRI AND UX UMa

The UV spectra of nova-like variables are dominated by emission from the accretion disk, modified by scattering in a wind emanating from the disk. Here, we model the spectra of RW Tri and UX UMa, the only two eclipsing nova-like variables which have been observed with the Hubble Space Telescope in the far-ultraviolet, in an attempt to constrain the geometry and the ionization structure of their winds. Using our Monte Carlo radiative transfer code, we computed spectra for simply parameterized axisymmetric biconical outflow models and were able to find plausible models for both systems. These reproduce the primary UV resonance lines—N v, Si iv, and C iv—in the observed spectra in and out of eclipse. The distribution of these ions in the wind models is similar in both cases as is the extent of the primary scattering regions in which these lines are formed. The inferred mass-loss rates are 6%–8% of the mass accretion rates for the systems. We discuss the implication of our point models for our understanding of accretion disk winds in cataclysmic variables.