Miracle-dz/UniFAR-FTUs huggingface dataset:
Hyaluronate for temporomandibular joint disorders.

BACKGROUND Temporomandibular joint disorders (TMD) refer to a group of heterogeneous pain and dysfunction conditions involving the masticatory system, reducing life quality of the sufferers. Intra-articular injection of hyaluronate for TMD has been used for nearly two decades but the clinical effectiveness of the agent has not been summarized in the form of a systematic review. OBJECTIVES To assess the effectiveness of intra-articular injection of hyaluronate both alone and in combination with other remedies on temporomandibular joint disorders. SEARCH STRATEGY Intensive electronic and handsearches were carried out. The Oral Health Group's Trials Register (September 2001), The Cochrane Library CENTRAL database (Issue 3, 2001), MEDLINE (1966- May 2001), PubMed ( up to March 2002), EMBASE (1974 - August 2001), SIGLE (1980 - December 2001), CBMdisc (1983 - July 2001, in Chinese) and Chinese Medical Library were searched. All the Chinese professional journals in the oral health field were handsearched and conference proceedings consulted. There was no language restriction. SELECTION CRITERIA Randomized or quasi-randomized controlled trials (RCTs), with single or double blind, design testing the effectiveness of hyaluronate for patients with temporomandibular joint disorders. DATA COLLECTION AND ANALYSIS Two reviewers independently extracted data, and three reviewers independently assessed the quality of included studies. The first authors of the selected articles were contacted for additional information. MAIN RESULTS Seven studies were included in the review. Three studies, including 109 patients with temporomandibular disorders, compared hyaluronate with placebo. Long term effects (three months or longer) are in favour of hyaluronate for the improvement of clinical signs/overall improvement of TMD (RR=1.71, 95%CI: 1.05, 2.77) from two of the studies (n=71). However, this conclusion was not stable enough at sensitivity analysis. Three studies provided data from 124 patients for the comparison of hyaluronate with glucocorticoids (one study also included a placebo group). Hyaluronate had the same short term and long term effects on the improvement of symptoms, clinical signs or overall conditions of the disorders as glucocorticoids. When comparing the effect of arthroscopy or arthrocentesis with and without hyaluronate, results were inconsistent. Hyaluronate had a potential in improving arthroscopic evaluation scores. Mild and transient adverse reactions such as discomfort or pain at the injection site were reported in the hyaluronate groups. No quality of life data were reported REVIEWER'S CONCLUSIONS There is insufficient, consistent evidence to either support or refute the use of hyaluronate for treating patients with TMD. Further high quality RCTs of hyaluronate need to be conducted before firm conclusions with regard to its effectiveness can be drawn.
Management of duodenal trauma: A retrospective review from the Panamerican Trauma Society

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Archaeological avifauna of Harataonga, Great Barrier Island, New Zealand: implications for avian palaeontology, Maori prehistory, and archaeofaunal recovery techniques

Abstract A recent analysis of archaeological bird remains from Harataonga Bay, Great Barrier Island is reported and compared with a prior study conducted in the 1960s. The assemblages come from two Maori occupations, one dating to ca. fourteenth century AD and the other to late prehistory. The new study identifies several previously unreported species for Harataonga, and the first record of prehistoric Maori use of Black Petrel or Taiko (Procellaria parkinsoni), and possibly Pycroft's Petrel (Pterodroma pycrofti). The assemblages are dominated by seabirds, a common pattern for the South Island but unusual for more northern areas, where forest birds are typically better represented. The limited forest birds are concentrated in the early occupation. Combining the two studies broadens our understanding of past species distributions on Great Barrier Island, and Maori use of these resources over time. Analytically, comparison of the two studies, one conducted some time ago, demonstrates the impact of fine-mesh sieves and in-lab processing on the observed assemblage size, composition, and diversity.
Role of Machine Learning Techniques to Tackle the COVID-19 Crisis: Systematic Review

BACKGROUND: SARS-CoV-2, the novel coronavirus responsible for COVID-19, has caused havoc worldwide, with patients presenting a spectrum of complications that have pushed health care experts to explore new technological solutions and treatment plans. Artificial Intelligence (AI)-based technologies have played a substantial role in solving complex problems, and several organizations have been swift to adopt and customize these technologies in response to the challenges posed by the COVID-19 pandemic. OBJECTIVE: The objective of this study was to conduct a systematic review of the literature on the role of AI as a comprehensive and decisive technology to fight the COVID-19 crisis in the fields of epidemiology, diagnosis, and disease progression. METHODS: A systematic search of PubMed, Web of Science, and CINAHL databases was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines to identify all potentially relevant studies published and made available online between December 1, 2019, and June 27, 2020. The search syntax was built using keywords specific to COVID-19 and AI. RESULTS: The search strategy resulted in 419 articles published and made available online during the aforementioned period. Of these, 130 publications were selected for further analyses. These publications were classified into 3 themes based on AI applications employed to combat the COVID-19 crisis: Computational Epidemiology, Early Detection and Diagnosis, and Disease Progression. Of the 130 studies, 71 (54.6%) focused on predicting the COVID-19 outbreak, the impact of containment policies, and potential drug discoveries, which were classified under the Computational Epidemiology theme. Next, 40 of 130 (30.8%) studies that applied AI techniques to detect COVID-19 by using patients' radiological images or laboratory test results were classified under the Early Detection and Diagnosis theme. Finally, 19 of the 130 studies (14.6%) that focused on predicting disease progression, outcomes (ie, recovery and mortality), length of hospital stay, and number of days spent in the intensive care unit for patients with COVID-19 were classified under the Disease Progression theme. CONCLUSIONS: In this systematic review, we assembled studies in the current COVID-19 literature that utilized AI-based methods to provide insights into different COVID-19 themes. Our findings highlight important variables, data types, and available COVID-19 resources that can assist in facilitating clinical and translational research.
Enhancing the clinical value of serum neurofilament light chain measurement

BACKGROUND Serum neurofilament light chain (sNFL) is becoming an important biomarker of neuro-axonal injury. Though sNFL correlates with CSF NFL (cNFL), 40% to 60% of variance remains unexplained. We aimed to mathematically adjust sNFL to strengthen its clinical value. METHODS We measured NFL in a blinded fashion in 1138 matched CSF and serum samples from 571 patients. Multiple linear regression (MLR) models constructed in the training cohort were validated in an independent cohort. RESULTS An MLR model that included age, blood urea nitrogen, alkaline phosphatase, creatinine, and weight improved correlations of cNFL with sNFL (from R2 = 0.57 to 0.67). Covariate adjustment significantly improved the correlation of sNFL with the number of contrast-enhancing lesions (from R2 = 0.18 to 0.28; 36% improvement) in the validation cohort of patients with multiple sclerosis (MS). Unexpectedly, only sNFL, but not cNFL, weakly but significantly correlated with cross-sectional MS severity outcomes. Investigating 2 nonoverlapping hypotheses, we showed that patients with proportionally higher sNFL to cNFL had higher clinical and radiological evidence of spinal cord (SC) injury and probably released NFL from peripheral axons into blood, bypassing the CSF. CONCLUSION sNFL captures 2 sources of axonal injury, central and peripheral, the latter reflecting SC damage, which primarily drives disability progression in MS. TRIAL REGISTRATION ClinicalTrials.gov NCT00794352. FUNDING Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH (AI001242 and AI001243).
DeepAmp: A Convolutional Neural Network Based Tool for Predicting Protein AMPylation Sites From Binary Profile Representation

AMPylation is an emerging post-translational modification that occurs on the hydroxyl group of threonine, serine, or tyrosine via a phosphodiester bond. AMPylators catalyze this process as covalent attachment of adenosine monophosphate to the amino acid side chain of a peptide. Recent studies have shown that this post-translational modification is directly responsible for regulation of neurodevelopment and neurodegeneration and also involved in many physiological processes. Despite the importance of this post-translational modification, there is no peptide sequence dataset available for conducting computational analysis. Therefore, so far, no computational approach has been proposed for predicting AMPylation. In this study, we introduce a new dataset of this distinct post-translational modification and develop a new machine learning tool using a deep convolutional neural network called DeepAmp to predict AMPylation sites in proteins. DeepAmp achieves 77.7%, 79.1%, 76.8%, and 0.55 in terms of Accuracy, Sensitivity, Specificity, and Matthews Correlation Coefficient (MCC) for AMPylation site prediction task, respectively. As the first machine learning model, DeepAmp demonstrate promising results which highlight its potential to solve this problem. Our presented dataset and DeepAmp as a standalone predictor are publicly available at https://github.com/MehediAzim/DeepAmp
Long‐range transport of ozone from the Los Angeles Basin: A case study

Airborne lidar measurements of ozone above the Los Angeles Basin on 17 July 2009 show orographic lifting of ozone from the surface to the free troposphere by the San Gabriel Mountains. Mixing ratios in excess of 100 parts‐per‐billion‐by‐volume (ppbv) were measured ∼4 km above mean sea level (ASL). These observations are in excellent agreement with published model studies, confirming that topographic venting by the so called “mountain chimney effect” is a potentially important pathway for removal of pollutants from the Los Angeles Basin. The lofting of ozone and other pollutants into the free troposphere also greatly increases the potential for long‐range transport from the Basin, and trajectory calculations suggest that some of this ozone may have been transported ∼1000 km to eastern Utah and western Colorado.
The enhancing effect on tidal signals of a submarine spring connected to a semi-infinite confined aquifer

Abstract Submarine springs play an important role in submarine groundwater discharge (SGD). To investigate the effects of these springs on the propagation of tidal signals in coastal confined aquifers, this paper considers a general coastal aquifer system with a submarine spring on the seabed where the length of the aquifer's offshore extent is finite and its submarine outlet is covered by an impermeable outlet-capping. An approximate analytical solution is obtained for describing the tidal head fluctuations in the aquifer. Solution analyses indicate that the error of the approximate analytical solution is negligible when both distances from the spring hole to the coastline and to the submarine outlet-capping are much greater than the radius of the spring hole. Sensitivity tests are conducted to investigate the effects of hydraulic properties, tidal and spring geometric configuration parameters on the tidal signal propagation in the inland aquifer. For aquifers with infinite offshore length, or without submarine springs, existing solutions in the literature are obtained. The comparison of groundwater head fluctuations for the cases with and without a submarine spring demonstrate the enhancing effect of the submarine spring on tidal signal propagation in the inland aquifer. Three situations that fit our model assumptions are given for future potential applications. A hypothetical example is used to show the possibility of identifying a spring's location using the present analytical solution together with tidal signals observed from inland wells. Editor D. Koutsoyiannis; Associate editor Y. Guttmann Citation Xia, Y.Q. , Li, H.L. , Yang, Y. , and Huang, W. , 2012. Enhancing effect on tidal signals of a submarine spring related to a semi-infinite confined aquifer. Hydrological Sciences Journal, 57 (6), 1231–1248.
The psychological predictors of acute and chronic pain in women following breast cancer surgery: A systematic review

The psychological predictors of acute and chronic pain in women following breast cancer surgery: A systematic review. Monica McCowat, MSc. ,School Psychological Sciences and Health, University of Strathclyde, UK Leanne Fleming, PhD. , School Psychological Sciences and Health, University of Strathclyde, UK Julie Vibholm, MSc. , Trainee Clinical Associate in Applied Psychology, NHS Greater Glasgow and Clyde, Glasgow, UK Diane Dixon, PhD. , School Psychological Sciences and Health, University of Strathclyde, UK Corresponding author: Diane Dixon, School Psychological Sciences and Health, University of Strathclyde, 40 George Street, Glasgow, G1 1QE, UK. Telephone: +44 (0)141 548 2571; e-mail:diane.dixon@strath.ac. uk
Attention, Gaze Shifting, and Dual-task Interference from Phonological Encoding in Spoken Word Planning Background to the Present Study

Controversy exists about whether dual-task interference from word planning reflects structural bottleneck or attentional control factors. Here, participants named pictures whose names could or could not be phonologically prepared, and they manually responded to arrows presented away from (Experiment 1), or superimposed onto, the pictures (Experiments 2 and 3); or they responded to tones (Experiment 4). Pictures and arrows/tones were presented at stimulus onset asynchronies of 0, 300, and 1,000 ms. Earlier research showed that vocal responding hampers auditory perception, which predicts earlier shifts of attention to the tones than to the arrows. Word planning yielded dual-task interference. Phonological preparation reduced the latencies of picture naming and gaze shifting. The preparation benefit was propagated into the latencies of the manual responses to the arrows but not to the tones. The malleability of the interference supports the attentional control account. This conclusion was corroborated by computer simulations showing that an extension of WEAVERϩϩ (A. Roelofs, 2003) with assumptions about the attentional control of tasks quantitatively accounts for the latencies of vocal responding, gaze shifting, and manual responding. It is often assumed that the extent to which a task can be performed without hindering other simultaneously performed tasks indexes the extent that the task is practiced and carried out by separate, independent, functional processing mechanisms (e. Spoken word production is a specialized human activity, and it is one of our most highly practiced everyday psychomotor skills. Some researchers believe, therefore, that most aspects of spoken word production need not slow the performance of a concurrent unrelated task (e.g., Levelt, Roelofs, & Meyer, 1999). Seemingly in contrast to this assumption, recent studies have shown that there are detrimental consequences of speaking for other highly practiced activities, such as driving a car (Kubose et al., 2006; Levy, Pashler, & Boer, 2006). It is unclear, though, whether the negative effects from speaking on concurrent driving arise from conceptualizing what to convey or actually planning the words. However, Ferreira and Pashler (2002) obtained evidence that word planning itself, in particular the stages of lemma retrieval and morphological encoding engaged in object naming, may hinder the performance of a concurrently performed, unrelated manual task, whereas only the stage of phonological encoding does not cause dual-task interference. The results of Ferreira and Pashler (2002) are somewhat surprising in the light of the finding that phonological encoding in object naming affects gaze shifting and the performance of another object-naming …
Traumatic brain injuries sustained in the Afghanistan and Iraq wars.

OVERVIEW When traumatic brain injury (TBI) occurs simultaneously with more obviously life-threatening wounds, it may go unrecognized. Civilians and military personnel working in or near combat zones are at risk for this injury. Blast-related and closed-head injuries, rather than penetrating injuries, constitute the majority of TBIs in this population. The authors describe the experiences of the Defense and Veterans Brain Injury Center team at Walter Reed Army Medical Center in Washington, DC, and present a composite case to illustrate the nurse's role in the assessment and care of the TBI patient.
Tamoxifen metabolism and efficacy in breast cancer – a prospective multicentre trial

Patrick Neven, Lynn Jongen, Anneleen Lintermans, Kathleen Van Asten, Chantal Blomme, Diether Lambrechts, An Poppe, Hans Wildiers, Anne-Sophie Dieudonné, Olivier Brouckaert, Jan Decloedt, Patrick Berteloot, Didier Verhoeven, Markus Joerger, Peter Vuylsteke, Wim Wynendaele, Minne Casteels, Sabine Van Huffel, Willem Lybaert, Johan Van Ginderachter, Robert Paridaens, Ignace Vergote, Vincent Olaf Dezentjé, Ben Van Calster, Henk-Jan Guchelaar
Bayesian inference for neighborhood filters with application in denoising

Range-weighted neighborhood filters are useful and popular for their edge-preserving property and simplicity, but they are originally proposed as intuitive tools. Previous works needed to connect them to other tools or models for indirect property reasoning or parameter estimation. In this paper, we introduce a unified empirical Bayesian framework to do both directly. A neighborhood noise model is proposed to reason and infer the Yaroslavsky, bilateral, and modified non-local means filters. An EM+ algorithm is devised to estimate the essential parameter, range variance, via the model fitting to empirical distributions. Finally, we apply this framework to color-image denoising. Experimental results show that the proposed model fits noisy images well and the range variance is estimated successfully. The image quality can also be improved by a proposed recursive fitting and filtering scheme.
DrsG from Streptococcus dysgalactiae subsp equisimilis inhibits the antimicrobial peptide

26 SIC and DRS are related proteins present in only four of the more than 200 Streptococcus pyogenes 27 emm-types. These proteins inhibit complement mediated lysis and/or the activity of certain 28 antimicrobial peptides. A gene encoding a homologue of these proteins, herein called DrsG, has 29 been identified in the related bacterium Streptococcus dysgalactiae subsp equisimilis (SDSE) . Here 30 we show that geographically dispersed isolates representing 14 of 50 emm-types examined possess 31 variants of drsG . However not all isolates within the drsG-positive emm-types possess the gene. 32 Sequence comparisons also reveal a high degree of conservation in different SDSE emm-types. To 33 examine the biological activity of DrsG, recombinant versions of two major DrsG variants, DrsGS 34 and DrsGL, were expressed and purified. Western blot analysis using antisera raised to these 35 proteins demonstrated both variants to be expressed and secreted into culture supernatant. Unlike 36 SIC, but similar to DRS, DrsG does not inhibit complement mediated lysis. However, like both SIC 37 and DRS, DrsG is a ligand of the cathelcidin LL-37 and is inhibitory to its bactericidal activity in in 38 vitro assays. The greatest similarity between DrsG and DRS/SIC is found in the signal sequence at 39 the amino terminus and proline rich domains in the C-terminal half of the protein. Conservation of 40 prolines in this latter region also suggests these residues are important in the biology of this family 41 of proteins. This is the first report demonstrating the activity of an AMP inhibitory protein in 42 SDSE. These results also suggest that inhibition of AMP activity is the primary function of this 43 family of proteins. The acquisition of complement inhibitory activity of SIC may reflect its 44 continuing evolution. growth 80% These results suggest that DrsG is capable of inhibiting the bactericidal activity of LL-37.
Seasonal Forecasting of Tropical Cyclone Landfall over Mozambique

Abstract The 2000 tropical cyclone season over the South Indian Ocean (SIO) was exceptional in terms of tropical cyclone landfall over Mozambique. Observed data suggest that SIO tropical cyclones have a track significantly more zonal during a La Nina event and tend to be more frequent when local SSTs are warmer. The combination of both conditions happened during the 2000 SIO tropical cyclone season and may explain the exceptional number of tropical cyclone landfalls over Mozambique during that season. A set of experiments using an atmospheric model of fairly high resolution (TL159, with a Gaussian grid spacing of 1.125°) forced by prescribed SSTs confirms the role of La Nina conditions and warmer local SSTs on the frequency of tropical cyclone landfalls over Mozambique. This also suggests that a numerical model can simulate the mechanisms responsible for the exceptional 2000 tropical cyclone season, and therefore could be used to explicitly predict the risk of landfall over Mozambique. A coupled model wit.
Low boreal wetlands as a source of atmospheric methane

Boreal wetlands are thought to be a large source of atmospheric methane, but this idea is based on very few measurements. Thus a regional survey in the low boreal forest region of central Ontario, Canada, consisting of 24 sites over 12 wetlands and 3 beaver ponds was conducted to determine the temporal and spatial trends in emissions and the net annual methane (CH4) flux. Conifer swamps represented nearly 50% of the wetland coverage, but emit a small amount of CH4 (seasonal means < 8 mg m−2 d−1). The significant emitters of CH4, in order from highest to lowest seasonal means, were beaver ponds (30–90 mg m−2 d−1), thicket swamps (0.1–88 mg m−2 d−1), and bogs (6–21 mg m−2 d−1). Mixed swamps, marshes, and fens emitted very little CH4 (< 3 mg m−2 d−1). Moisture saturation was the key determinant of high emissions, and when satisfied, differences in emissions could be explained by peat and sediment temperatures. On the basis of the areal extent of wetlands from peatland inventories we calculate that the low boreal region of Canada contributes approximately 0.15Tg CH4 yr−1 to the atmosphere. This is an order of magnitude lower than the flux would be using the estimate of Aselmann and Crutzen (1989) for the same boreal region.