Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Butylphthalide Combined with Fasudil on Inflammatory Factors, Cognitive Function and Vascular Endothelial Function in Patients with Subarachnoid Hemorrhage Complicated with Cerebral Vasospasm

Objective: To investigate the effect of butylphthalide combined with fasudil in the treatment of subarachnoid hemorrhage (SAH) with cerebral vasospasm (CVS) on inflammatory factors, cognitive function and vascular endothelial function. Methods: It is a retrospective study in which a total of 104 patients with SAH with CVS admitted to Baoding First Central Hospital from July 2020 to February 2022 were selected and randomly divided into two groups by drawing lots. Patients in the control group were treated with basic symptomatic treatment, while those in the observation group were treated with butylphthalide soft capsule combined with fasudil hydrochloride injection on the basis of the control group. Before and after treatment, serum neuron specific enolase (NSE), tumor necrosis factor-α(TNF-α), interleukin-8(IL-8), hypersensitive C-reactive protein (CRP), Birmingham Cognitive Screen test (BCoS) score, serum soluble intercellular adhesion molecule-1(ICAM-1), serum endothelin-1(ET-1), vascular endothelial growth factor (VEGF) levels, and endothelium-dependent vasodilation function (FMD) in the two groups were compared. Results: After treatment, the expression levels of NSE, TNF-α, IL-8 and CRP in the two groups were significantly decreased, and the expression levels of all indicators in the observation group were lower than that in the control group (p<0.05). After treatment, the scores of orientations, attention, memory, language, practice and action in the two groups were significantly increased, and the scores of all dimensions in the observation group were higher than those in the control group (p<0.05). After treatment, S-ICAM-1, ET-1, VEGF, FMD decreased in both groups, and all indicators of the observation group were lower than those of the control group, with statistically significant differences (p<0.05). Conclusion: Butylphthalide combined with fasudil therapy was found as effective in reducing inflammatory factors, ameliorating cognitive function and vascular endothelial function in patients with subarachnoid hemorrhage complicated with cerebral vasospasm.
Un effet modérateur des processus cognitifs de l'entrepreneur sur les opportunités d'affaires situées dans l'espace géographique

The process of business creation is based on the initiatives of the contractor seen as the main actor interactions located heart of the business community. It determines the selection of the environment in which it wants to develop business opportunities identified. This approach assumes that the entrepreneur adapts its behavior based on the perception and interpretation of business opportunities he finds in his environment, from his own cognitive abilities. Seizing opportunities thus appears as a process of cognitive construction that involves the dimensions of the geo-environmental space. We explore the logic of this construction and we offer an interpretation of this scene for the period from 2001 to 2009 on the register of companies created and stored in the Congolese national statistics.
Role of Acute Hepatitis E Virus Super Infection in Progression Stage of Liver Cirrhosis

Background: Despite acute hepatitis E virus (HEV) infection is a self-limiting acute infection, it could be a cause of acute on top of chronic liver failure (ACLF) in patients with chronic liver disease. Thus, identification role of HEV superinfection in deterioration of liver cirrhosis with early treatment could save life of those patients. Aim: To determine the percentage and the role of HEV infection in order to detect outcomes of patients with ACLF, to find effect of HEV infection on liver, kidney functions and coagulation profile, and to find specific clinical or laboratory characteristics of these patients if present. Subjects and methods: This cross-sectional study was conducted at Tropical Medicine Department. and Clinical Pathology Department, Zagazig University Hospitals on patients with liver cirrhosis; either compensated, decompensated (who admitted for ascites for control, follow up upper GIT endoscope, spontaneous bacterial peritonitis) or in those who have chronic liver disease and experience acute hepatic decompensation, which leads to acute liver failure (jaundice, prolonged INR), as well as one or more extrahepatic organ failures. All patients had standard laboratory evaluations, including the detection of HEV IgM by ELISA technique. Results: The incidence of HEV was 18% in ACLF cases and ACLF cases with positive HEV showing higher MELD score than ACLF cases with negative HEV. Conclusion: ACLF cases with positive HEV have higher MELD score than ACLF cases with negative HEV (statistically significant) but regarding Child score, there was statistically non-significant difference.
Socio-demographic and antenatal risk factors of brain tumor in children and young people: A matched case-control study from Karachi, Pakistan

Background: Brain tumors are a common cause of morbidity, disability, cognitive deterioration and mortality in children, even after treatment. Little is know about the specific causes. The study aimed to assess potential socio-demographic and antenatal factors in primary brain tumor (PBTs) in children and young people (CYP) in Karachi, Pakistan. Designs and methods: A single center hospital based matched case control study in Karachi, Pakistan. Cases were defined as CYP aged between 5 and 21 years with any histological type and grade of primary brain tumor of any histology, stage or grade. Data were collected from parents of 244 patients at the selected center between 2017 and 2021 via telephonic interview. Controls were 5–21 years old CYP admitted with non-oncological diagnoses matched on age and sex. Matched Odds Ratios for predictors of brain tumor in children were derived. Those of statistical significance were included in a multivariable logistic regression model. Results: In the adjusted model, lower paternal education (matched adjusted odds ratio (maOR) 2.46; 95% CI 1.09–5.55), higher household monthly income (maOR 3.4; 95% CI 1.1–10.2), antenatal paternal use of addictive substances (maOR 19.5; 95% CI 2.1–179.8), and antenatal maternal use of analgesics during pregnancy (maOR 3.0; 95% CI 1.2–7.9) were all independently predictive of brain tumors. Conclusion: This matched case-control study found novel associations between maternal use of analgesics, paternal use of addictive substances, higher household income, and lower paternal education and Primary Brain Tumors in Children and Young People. Longitudinal multicenter studies will be required to test these associations prospectively.
ROUTE SELECTION CONSIDERING TRAVEL TIME VARIABILITY

Most conventional route guidance systems select the optimal route on the basis of the minimum expected route travel time. However, as a result of the inherent variation in driving conditions, the route travel time that drivers will experience may be longer or shorter than the expected mean travel time. Drivers are likely to have a lower tolerance for experiencing travel times that exceed their expectation and as a result, drivers may want to select routes that provide them with smaller travel time variation. While this is clearly desirable it is not clear whether the paths providing the minimum average travel time, are also the optimal paths for other levels of travel time reliability. This paper examines the impact that routing strategy has on route selection. Specifically, the proportion of paths that change when drivers alter their route selection criteria from selecting the minimum travel path computed on the basis of the average travel time to that computed on the basis of say the 95th percentile travel time is computed. The analysis, conducted using simulation results from a network of a portion of Seattle, Washington, indicates that if a routing system selects routes on the basis of the 95th percentile travel time, then approximately 15% of all routes would be different than the minimum mean travel time routes. The results indicate that there may exist opportunities for improving the reliability of trip travel times by changing the route selection strategy to directly consider travel time variability
Antibacterial effect of cinnamon essential oil in combination with traditional antibiotics

: Drug-resistant microorganisms are on the rise, posing a danger to successful bacterial illness treatment and increasing the demand for new antibacterial drugs. Natural products are currently and will continue to be the principal source of antibacterial therapeutic agents. This study's aim was to assess the antibacterial effects of Cinnamon essential oil (EO) alone and in combination with several traditional antibiotics against multi-drug resistant Staphylococcussp. The antibacterial efficacy was determined using the disc diffusion method. As a result, cinnamon oil possesses antibacterial properties with MICs were 1.25 mgml -1 and 2.5 mgml -1 for S.epidermidisandS. aureus, respectively. Commercial antimicrobials and essential oil work together most effectively when combined. Scanning electron microscopy revealed morphological alterations in Staphylococcus cells, indicating cell membrane damage. Cinnamon essential oil composition was assessed using GC/MS with polonicumtoxin B (14.71%), linalool (5.36%), cinnamaldehyde (3.37%), 5, 5-dimethyl-4-hydroxy-1-phenyl-1-hexen-3-one (6.47%), 2-methyl benzofuran (5.79%), and 1,2-propanediol (6.32%). This study presented a natural product as a substitute for chemical therapeutics, addressing the problem of antibiotic resistance.
The Potential of Web Mining in Business Predictive Analysis from Raw Data to Actionable Predictions

This research paper explores the potential of web mining in business predictive analysis, focusing on the transformation of raw data into actionable predictions. The transformation of raw data into actionable predictions is explored in this research paper, which examines the potential of web mining in business analysis. With the growth of the internet and digital data, businesses can benefit by leveraging web mining tactics to collect valuable insights and make well-informed choices. Businesses can mine the web to find information from multiple sources, including websites, social media sites, and search engines, to help them predict their customers' actions, market developments, and competition intelligence. The paper covers the basics of web mining techniques and their applications in predictive business analysis, including future growth prospects.
Comparative Studies on Sub-Family Maloideae (Rosaceae) Plants in Egypt

This present study covered 8 species (7genera) belonging to the subfamily Maloideae (Rosaceae). These plant samples were collected from 5 different Egyptian sites. The study includes morphological and anatomical studies for all the plant organs both vegetative or reproductive. The 68 recorded characters put in data matrix and these results were analyzed numerically using the (MVSP) program to determine the similarity between these studied species. The program classified the studied plant samples into two clusters, the first cluster includes 3 species (No.1-3), the highest similarity was 72.956 between Cydonia sp. and Crataegus sp. , while the lowest similarity was 64.052 between Cydonia sp. and Cotoneaster sp. The second cluster includes the remainder 5 species; from (No. 4 to 8), The highest similarity was 73.054 between species Pyrus calleryana and P. communis , while the lowest similarity was 59.740 between Rhiphiolepis sp. and the other 4 samples in the same cluster ( Eriobotrya sp., Malus sp., Pyrus calleryana and P. communis .). Also, the results used in the constructing of an indented key to identified and to easily the distinguish the eight studied samples.
Effects of laccase from Botrytis cinerea on the oxidative degradation of anthocyanins

This work aimed to study the degradation kinetics of five grape anthocyanins caused by laccase from Botrytis cinerea. In individual solutions, the anthocyanins with three substituents in the B-ring—petunidin, delphinidin and malvidin 3-O-glucosides—were degraded much faster than those with two substituents. In the latter case, cyanidin 3-O-glucoside did not degrade as quickly, and peonidin-3-O-glucoside, in particular, was not degraded by laccase at all. In contrast, when an equimolar solution of the five anthocyanins was used, the differences in the degradation kinetics of all anthocyanins were lessened, probably because the less reactive anthocyanins were able to polymerise with the quinones formed by the laccase action on the more reactive anthocyanins. Finally, supplementation with (-)-epicatechin, glutathione and especially seed tannins seemed to protect the red colour from laccase.
Périodes des fonctions harmoniques bornées

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Planning at the Landscape Scale

1. Introduction: The Challenge of Planning at the Landscape Scale 2. Why the Landscape Scale? 3. People and Landscapes 4. Comprehending the Landscape Scale 5. Principles for Landscape-Scale Planning 6. Instruments for Landscape-Scale Planning 7. Practices of Landscape-Scale Planning 8. The Virtuous Circle References
Review on fiber-optic sensing in health monitoring of power grids

Abstract. Fiber-optic sensing technology is best adapted to health monitoring and evaluation of power grids because of its immunity of electromagnetic interference, capabilities of multiplexing and distributed sensing, and tolerance to harsh environments. We review key fiber-optic sensing technologies, including fiber Bragg gratings, fiber-optic interferometers, optical time domain reflectometries, and their applications in three main parts of power grids, transformers, power towers, and overhead transmission lines, during the past 20 years. In particular, optical fiber composite overhead ground wire and optical phase conductor applied in power grids are the areas of great potential to go further. The perspectives of an intelligent fault diagnosis subsystem for power grids based on a fiber-optic sensing network are discussed, and related on-going work is described. The review shall be of benefit to both engineers and researchers in power grids and fiber-optic sensing.
Cementation in High-Latitude Dunes.

Abstract : Cementing of dune sands by carbonates has not been considered to proceed rapidly in high-latitude regions. This study indicates that dunes along the Scotland coast, however, are actively being cemented by carbonates and that this process is quite widespread. This cementation is associated primarily with percolating waters in the vadose environment. Cementing of the dune sands stabilizes the dune fields and increases considerably trafficability across such landforms. (Author)
Arctic cloud cover during the summers of 1977-1979

Cloud cover in the Artic Basin has been charted from satellite images at approximately 3 day intervals for the months of May to August from 1977 to 1979. Three classes of cloud thickness at three altitudes were mapped and digitized together with sea level pressure. Cloudiness was found to be heterogeneous in space and time. Optically thick clouds had high tops and were associated with low pressure systems and airmasses advected from the south. Clouds of moderate thickness were the most prevalent. Cloud-free skies were most often colocated with high pressure. The central Arctic was cloudest, whereas the Canadian Archipelago was least cloudy. Overall, thick clouds were considerably less common than in earlier analyses drawn from ground and drifting station data. Cloud-free episodes throughout the basin persisted long enough to significantly affect the surface radiation budget and the dissipation of snow and ice. Our results indicate that climate models which attempt to assess the impact of CO/sub 2/ on the radiation budget in the high latitudes should take into account the heterogeneity of cloud extent, thickness and height in the Arctic Basin. 28 refs., 45 figs., 3 tabs.
Multilocular cystic renal cell carcinoma a diagnostic dilemma: A case report in a 30-year-old woman

Multilocular cystic renal cell carcinoma (MCRCC), also known as multilocular clear cell renal cell carcinoma (RCC), is a rare cystic tumor of the kidney with an excellent outcome. It occurs in about 3.1-6% of the conventional RCC. It is usually included in the group of tumors of undetermined malignant potential with low nuclear grade. We present a case of MCRCC in a 30-year-old female patient presenting incidentally as an apparently benign-looking multicystic space occupying lesion in the upper pole of right kidney. Right-sided simple nephrectomy was performed, and on histopathologic examination it was found to be MCRCC, stage 1 with Fuhrman nuclear grade 1. Immunohistochemistry with epithelial membrane antigen and vimentin confirmed the diagnosis.
Re: Intermittent Androgen Suppression for Rising PSA Level After Radiotherapy Crook JM, O'Callaghan CJ, Duncan G, et al.

Re: Dysregulation of Cholesterol Homeostasis in HumanProstate Cancer Through Loss of ABCA1Lee BH, Taylor MG, Robinet P, et al.Cancer Res 2013;73:1211–8Experts’ summary:Lee et al. explore the regulation and loss of ATP-bindingcassette transporter A1 (ABCA1), a transmembrane transport-er that serves as a key mediator of cellular cholesterol efflux.Toward this end, the authors demonstrate that the promoteroftheABCA1geneisepigenetically silencedbyhypermethyla-tion in the human prostate tumor cell line, LNCaP, butnot in a second prostate tumor cell line, DU145. They demon-strate that LNCaP cells have higher basal cholesterol levelsrelative to DU145 cells. Demethylation (using 5-aza-2
AMELIORATIVE IMPACTS OF GRAPE SEED EXTRACT ON GROWTH PERFORMANCE, IMMUNE RESPONSE, ANTIOXIDANT CAPACITY AND BIOCHEMICAL CONSTITUENTS IN BROILERS EXPOSED TO FUMONISIN B1

SUMMARY umonisin B1 (FB1) is a mold metabolite produced by Fusarium species that is frequently found in corn worldwide. It is toxic to both liver and kidney. This research aimed to assess the influence of grape seed extract (GSE) on reducing toxic influences of Fumonisin B1 (FB1) in broilers by examining the growth performance, immune response, antioxidant capacity and biochemical constituents. A total of 240 one-day-old Ross-308 chicks were randomly allocated into four treatments of six replicates each (10 birds per replicate), fed ad libitum for five weeks with the following dietary treatments: 1. Basal diet (control); 2. Basal diet + 400 mg/kg FB1 contaminated diet (FB1); 3. Basal diet + FB1 (400 mg/kg) + GSE (250 mg/kg); and 4. Basal diet + FB1 (400 mg/kg) + GSE (500 mg/kg). Results revealed that inclusion of FB1 in the diet of birds resulted in deleterious effects on all parameters traits included in this study. The addition of GSE at levels of 250 or 500 mg/kg of diet to the FB1–containing diet significantly improved the adverse effects of FB1 on growth performance, serum immunoglobulin contents, serum biochemical contents, and enzyme activities in the liver, malondialdehyde content and total antioxidant capacity and glutathione peroxidase concentration within the liver and serum. Moreover, 500 mg GSE / kg of diet surpasses the other level 250 mg GSE /kg diet concerning all above–mentioned the parameters. In conclusion, broilers performance, some blood constituents, oxidative stress and liver function were significantly affected by FB1 (400 mg) treatment; the addition of GSE (250 or 500 mg/kg of diet ) to the FB1–contaminated diet significantly recovered the adverse effects of FB1 on these traits; the protective effect of 500 mg GSE /kg of diet against the toxic effects of FB1 was greater than that of 250 mg GSE/kg of diet; and these improvements may contribute to a solution of FB1 problems in broiler chickens.
The pathogenic mechanism of TAR DNA-binding protein 43 (TDP-43) in amyotrophic lateral sclerosis

The onset of amyotrophic lateral sclerosis is usually characterized by focal death of both upper and/or lower motor neurons occurring in the motor cortex, basal ganglia, brainstem, and spinal cord, and commonly involves the muscles of the upper and/or lower extremities, and the muscles of the bulbar and/or respiratory regions. However, as the disease progresses, it affects the adjacent body regions, leading to generalized muscle weakness, occasionally along with memory, cognitive, behavioral, and language impairments; respiratory dysfunction occurs at the final stage of the disease. The disease has a complicated pathophysiology and currently, only riluzole, edaravone, and phenylbutyrate/taurursodiol are licensed to treat amyotrophic lateral sclerosis in many industrialized countries. The TAR DNA-binding protein 43 inclusions are observed in 97% of those diagnosed with amyotrophic lateral sclerosis. This review provides a preliminary overview of the potential effects of TAR DNA-binding protein 43 in the pathogenesis of amyotrophic lateral sclerosis, including the abnormalities in nucleoplasmic transport, RNA function, post-translational modification, liquid-liquid phase separation, stress granules, mitochondrial dysfunction, oxidative stress, axonal transport, protein quality control system, and non-cellular autonomous functions (e.g., glial cell functions and prion-like propagation).
Sistem Parkir Cepat Berbasis Mikrokontroler AT89C51

Sistem Parkir Cepat Berbasis Mikrokontroler AT89C51 adalah system parkir yang dirancang untuk mempercepat proses pencarian tempat parkir dengan mendisplaykan tempat parkir kosong pada papan display Light Emitting Diode (LED). Dengan melihat display tersebut, seorang pengendara mobil dapat langsung mengarahkan mobil ke tempat parkir yang kosong sehingga menjadi proses parkir cepat. Prototipe system rangkaian ini menggunakan mikrokontroler AT89C51 sebagai komponen pengatur rangkaian keseluruhan, Light Dependent Resistor (LDR) sebagai sensor yang mendeteksi adanya mobil untuk membuka dan menutup pintu gerbang parkir dan pendeteksi adanya mobil pada tempat parkir, LED sebagai indicator bila ada mobil di suatu tempat parkir dan sebuah Liquid Crystal Display (LCD) untuk mendisplaykan bahwa tempat parkir telah penuh atau belum. Sesudah prototype rangkaian dibuat dan diuji rangkaian ini bekerja dengan baik sesuai rancangan.
Europa: Prospects for an ocean and exobiological implications

As far as we know, Earth is the only planet in our solar system that supports life. It is natural, therefore, that our understanding of life as a planetary phenomenon is based upon Earth-like planets. There are environments in the solar system where liquid water, commonly believed to be a prerequisite for biological activity, may exist in a distinctly non-Earth-like environment. One such location is Europa, one of the Galilean satellites of Jupiter. The possibility that liquid water exists on Europa presents us with some interesting exobiological implications concerning the potential of the satellite to support life. Topics include the following: an ocean on Europa; thermal evolution of Europa; Europa's three models; exobiological implications; early conditions of Europa; low-temperature abiotic chemistry; possibility of the emergence of life on Europa; prerequisites for the habitability of Europa; energy sources for biosynthesis and metabolic activity; habitability of Europa by anaerobic life; and habitability by aerobic life.