Miracle-dz/UniFAR-FTUs huggingface dataset:
On the Treatment of MRSA Skin and Soft Tissue Infection with Ceftaroline and Linezolid

Skin and Soft Tissue infections (SSTIs) have imposed substantial economic and clinical burdens on the world. The growing prevalence of SSTIs is due in large part to Methicillin-Resistant S. aureus (MRSA), known for its notorious multidrug resistance and virulence. The recent emergence of vancomycin-resistant isolates promoted the exploration for non-inferior and safe alternatives. In this work, an overview of MRSA-induced SSTIs will be provided, followed by a review of the mechanism of action, clinical efficacy, adverse effects of two potential candidates, namely ceftaroline and linezolid. Investigations on the exact mechanism of linezolid translation arrest, linezolid-associated neuropathy, and pharmacoeconomic comparison between linezolid and ceftaroline are expected in future studies.
Seasonal Variability and Future Projection of Ocean Acidification on the East China Sea Shelf off the Changjiang Estuary

Ocean acidification (OA) occurs universally in the world’s oceans. Marginal seas are facing more serious OA than the open ocean due to strong anthropogenic and natural impacts. This study investigates carbonate dynamics on the East China Sea (ECS) shelf off the Changjiang Estuary using field observations made from 2015 to 2019 that cover all four seasons. In the low productivity cold seasons, the water was well-mixed vertically. The coastal area and the northern ECS were occupied by water characterized by high dissolved inorganic carbon (DIC), low pH25 (pH at 25°C), and low ΩAr (saturation state index of aragonite), and influenced by the coastal water from the Yellow Sea (YS). However, during highly productive warm seasons, pH25 and ΩAr increased in the surface water but decreased in the bottom water as a result of strong biological DIC uptake in the surface water and CO2 production by strong organic matter remineralization in the bottom water. Strong remineralization decreased pH25 and ΩAr by 0.18 ± 0.08 and 0.73 ± 0.35 in the hypoxic bottom water in summer, even though the bottom water remained oversaturated with respect to aragonite (ΩAr > 1.0) during the surveys. Under the context of global OA and the strong seasonal acidification, the projected bottom water on the ECS shelf will be corrosive for aragonite by mid-century.
Self-assembled liquid crystalline solution processable semiconductors

This work describes the development of solution processable liquid crystalline semiconductors and their applications in field-effect transistors. The relationship between liquid crystal molecular structure, its corresponding phase behaviour and electrical performance is examined. Molecular design methodology is employed to control the liquid crystalline morphology. The thermal, optical and electrical behaviour of these materials is characterised and X-ray diffraction scattering technique is used to reveal details of morphology and molecular orientation.
Evaluating the Spring-Neap Tidal Effects on Chlorophyll-a Variations Based on the Geostationary Satellite

Tides are the dominant hydrodynamic processes in most continental shelf seas and have been proven to have a significant impact on both marine ecosystem dynamics and biogeochemical cycles. In situ and satellite observations have suggested that the spring-neap tide results in fluctuations of chlorophyll-a concentrations (Chl-a) with a fortnightly period in some shelf waters. However, a large number of missing values and low observation frequency in satellite-observed Chl-a have been recognized as the major obstacle to investigating the regional pattern showing where and to what extent of the effects of spring-neap tide on Chl-a and the seasonal variations in the effects within a relatively large region. Taking Himawari-8 as an example, a simple algorithm appropriate for geostationary satellites was proposed in this study with the purpose of obtaining a tide-related daily climatological Chl-a dataset (TDCD) and to quantitatively estimate the effects of the spring-neap tide on Chl-a variations. Based on the Chl-a time series from TDCD, significant fortnightly signals of Chl-a fluctuations and high contribution together with high explanations of the fortnightly fluctuations for Chl-a variations were found in some specific inshore waters, especially in the East China Sea, Bay of Bengal, South China Sea, and northern Australian waters. The spring-neap tide was found able to induce the spatio-temporal fortnightly fluctuations of Chl-a with an annual amplitude of 12–33% of the mean in these inshore areas. Significant seasonal variations in the fortnightly fluctuation of Chl-a were observed in the temperate continental shelf regions, while levels remained relatively stable in the tropical waters. Further analysis implied that the spatio-temporal fortnightly fluctuations of Chl-a were closely associated with the tidal current differences between the spring and neap tides. Seasonal variations in the tidal current differences were found to be a key driving factor for seasonal fluctuations of the spring-neap tidal effects on Chl-a in the temperate continental shelf regions. This study provides a better understanding of tide-related marine ecosystem dynamics and biogeochemical cycles and is helpful in improving physical–biogeochemical models.
Added Value of Genomic Surveillance of Virulence Factors in Shiga Toxin-Producing Escherichia coli in New South Wales, Australia

The disease caused by Shiga toxin-producing Escherichia coli (STEC) remains a significant public health challenge globally, but the incidence of human STEC infections in Australia remains relatively low. This study examined the virulence characteristics and diversity of STEC isolates in the state of New South Wales between December 2017 and May 2020. Utilisation of both whole and core genome multi-locus sequence typing (MLST) allowed for the inference of genomic diversity and detection of isolates that were likely to be epidemiologically linked. The most common STEC serotype and stx subtype detected in this study were O157:H7 and stx1a, respectively. A genomic scan of other virulence factors present in STEC suggested interplay between iron uptake system and virulence factors that mediate either iron release or countermeasures against host defence that could result in a reduction of stx1a expression. This reduced expression of the dominant stx genotype could contribute to the reduced incidence of STEC-related illness in Australia. Genomic surveillance of STEC becomes an important part of public health response and ongoing interrogation of virulence factors in STEC offers additional insights for the public health risk assessment.
The Protein Paradox: Elucidating the Complex Nutritional Ecology of the Invasive Berry Pest, Spotted-Wing Drosophila (Diptera: Drosophila suzukii)

Spotted-wing drosophila (SWD), Drosophila suzukii, has become one of the most widely studied insect species over the last decade, largely due to its recent invasion and rapid expansion across the Americas and Europe. Unlike other drosophilid species, which colonize rotting fruit, SWD females possess a serrated ovipositor that allows them to lay eggs in intact ripening fruit, causing significant economic problems for fruit/berry producers worldwide. Though an impressive amount of research has been conducted on SWD's ecology and physiology, aspects of their nutritional ecology remain ambiguous. This review synthesizes the research to date to provide a more comprehensive view of SWD's nutritional relationship with its fruit hosts and associated microbes. Overall, data suggest that SWD's ability to utilize novel resources is likely due to changes in their ecological, rather than physiological, niche that are largely mediated by microbial associations. Studies show that SWD's nutrient intake is comparable to other drosophilid species, indicating limited adaptation to feeding on lower-protein resources. Instead, data show that fruit protein content is a reliable predictor of host suitability and that fruit-microbe dynamics have a strong impact on protein availability. In particularly, fruit protein increases after infestation with SWD-associated microbes, suggesting that initially-suboptimal intact fruits can become protein-rich on a timeframe that is relevant for larval nutrition. This body of work suggests that microbial associations between flies and their fruit hosts can compensate for the nutritional differences between intact and rotting fruit, and that these relationships are likely responsible for SWD's expanded nutritional niche.
FUNDAMENTAL MOVEMENT ASSESSMENT OF YOUNG FEMALE GYMNASTS

The purpose of this study was to identify physical and motor skills of talent identified female gymnasts. Sixteen gymnasts aged five to eight years completed anthropometry, movement ABC, flexibility, strength, and jumping tests. Movement ABC testing revealed that whilst none of the gymnasts were motor impaired, strong fundamental motor skills can’t be assumed except for in the area of static balance. A number of the anthropometric, physiological and biomechanical test results revealed significant age effects which would therefore require large normative data sets for reliability. With the exception of anthropometry, other tests results (excluding those affected by age) showed large variation across the group. Follow-up research is needed to determine whether the tests with large group variation can identify the child with Olympic gymnastics potential.
Transmission properties of a right-angle microstrip bend with and without a miter

The transmission properties of a microstrip bend with and without a miter joint are investigated based on the waveguide model and using the Green's theorem approach. Unlike the conventional mode-matching technique, this approach does not require a modal description of fields inside the discontinuity region. Instead, the fields on the two sides of the discontinuity are related by applying the Green's theorem with an appropriate choice of an auxiliary function which plays the role analogous to that of the testing function in the method of moments. The selection of the auxiliary function is not systematic and involves good physical insight to the problem under study. Scattering parameters for the bend are presented which agree well with the quasistatic results at low frequencies. Significant improvement in the transmission properties is observed for the bend with a miter. It is noted that by themselves, the results provide an accuracy check for the more sophisticated integral equation approach which can handle arbitrarily shaped boundaries. Moreover, with a slight modification, this technique may be extended to study microstrip corners with an arbitrary miter. >
Instillation Checking Using Long Short-Term Memories for Ophthalmology Patients

In this paper, a checking system for eye lotion instillations of ophthalmology patients is proposed, using a neural network. It first estimates tilt angles of the eye dropper bottle from acceleration values measured by a triaxial sensor. A sequence of such estimated values is next presented to a discrimination model after network learning, and its output value is considered to be a certainty degree indicating whether an eye lotion is applied at the time zone corresponding to the sequence. The final judgement for the instillation is made by conducting thresholding of the certainty degree. The proposed method employs either a long short-term memory (LSTM for short) or a bidirectional long short-term memory (B_LSTM for short) to construct the discrimination model. Experimental results using practical data reveal that the B_LSTM-based model achieves favorable metric values compared to the LSTM-based model. In addition, it is explored whether the metric values depend on the interval between the time points when the tilt values are measured.
Neutrophils—From Bone Marrow to First-Line Defense of the Innate Immune System

Neutrophils (polymorphonuclear cells; PMNs) form a first line of defense against pathogens and are therefore an important component of the innate immune response. As a result of poorly controlled activation, however, PMNs can also mediate tissue damage in numerous diseases, often by increasing tissue inflammation and injury. According to current knowledge, PMNs are not only part of the pathogenesis of infectious and autoimmune diseases but also of conditions with disturbed tissue homeostasis such as trauma and shock. Scientific advances in the past two decades have changed the role of neutrophils from that of solely immune defense cells to cells that are responsible for the general integrity of the body, even in the absence of pathogens. To better understand PMN function in the human organism, our review outlines the role of PMNs within the innate immune system. This review provides an overview of the migration of PMNs from the vascular compartment to the target tissue as well as their chemotactic processes and illuminates crucial neutrophil immune properties at the site of the lesion. The review is focused on the formation of chemotactic gradients in interaction with the extracellular matrix (ECM) and the influence of the ECM on PMN function. In addition, our review summarizes current knowledge about the phenomenon of bidirectional and reverse PMN migration, neutrophil microtubules, and the microtubule organizing center in PMN migration. As a conclusive feature, we review and discuss new findings about neutrophil behavior in cancer environment and tumor tissue.
B-Vitamins and Choline in Human Milk Are Not Impacted by a Preconception Lipid-Based Nutrient Supplement, but Differ Among Three Low-to-Middle Income Settings—Findings From the Women First Trial

Introduction: Optimal human milk (HM) B-vitamin concentrations remain undefined, especially in areas where undernutrition is prevalent. The impact of supplementation pre-conception through pregnancy on HM B-vitamin composition remains unknown. Methods: Human milk (HM) was collected at 2-weeks postpartum from 200 women in Guatemala, India, and Pakistan (the Women First Trial). The women were randomized to start a lipid-based nutrient supplement before conception, at end of the first trimester, or not at all; intervention continued until delivery. HM concentrations of eight B-vitamins and choline were assessed via ultra-performance liquid chromatography-tandem mass spectrometry. Maternal diet was assessed in early pregnancy, and infant growth followed through 6 months post-delivery. Results: Despite supplement exposure averaging 15.7 (pre-conception arm) and 6.0 months (prenatal arm), HM B-vitamins did not differ between arms, but site differences were evident. Guatemala had higher HM concentrations of vitamin B3 than Pakistan and India. Pakistan had higher HM concentrations of thiamin and vitamin B6 than India and Guatemala. Cohort average HM vitamin B2 (162 ± 79 μg/L) and B6 (31.8 ± 24.6 μg/L) fell below values defined as deficient in 81.5 and 85.5% of samples, potentially reflecting sampling procedures and timing. Maternal dietary intakes of only vitamin B6 and choline were associated with the corresponding concentrations in HM (p < 0.005). No HM B-vitamin concentrations were associated with infant growth. Conclusion: Prenatal supplementation for at least 6 months had no impact on HM B-vitamin concentrations at 2-weeks postpartum. Results suggest that the adequacy of HM composition was generally maintained, with potential exceptions of vitamin B2 and B6.
MalDuoNet: A DualNet Framework to Detect Android Malware

Today mobile phones provide a wide range of applications that make our daily life easy. With popularity, smartphones have become a target for cybercrime where malicious apps are developed to acquire sensitive information or corrupt data. To mitigate this issue and to improve the security in mobile devices, different techniques have been used. These techniques can be broadly classified as static, dynamic and hybrid approaches. In this paper, a static-based model MalDuoNet is proposed to detect Android malwares, which uses a DualNet framework to analyze the features from the API calls. In the MalDuoNet model, one sub-network is focused to learn the features relevant to malicious behavior and the other sub-network is focused to learn the features in general. Thus it enables the model to learn complementary features which in turn helps get richer features for analysis. Then the features from the two sub-networks are combined in the final fused classifier for the final classification. In addition, each of the feature extractors has a separate classifier so that each sub-network can optimize its performance separately. The experimental results demonstrate that the MalDuoNet model outperforms the two baseline models with single network.
Printed monopole slot antenna for penta‐band operation in the folder‐type mobile phone

A monopole slot antenna suitable for folder‐type mobile phone application is presented. The antenna is placed at the hinge position of the mobile phone and occupies a small area of 15 × 40 mm2 on the top portion of the main circuit board of the mobile phone. The antenna can generate two wide operating bands to cover GSM850/900/1800/1900/UMTS penta‐band operation for the mobile phone in either the open state (talk condition) or close state (standby condition), although the two states have different ground plane conditions for the antenna. This behavior is achieved by connecting the upper ground of the folder‐type mobile phone to its main ground on the main circuit board not at the hinge position but at about the center of the side edge of the main ground where the excited surface current distributions are small. This greatly reduces the effects of the different orientations of the upper ground to the main ground on the antenna performances in the open and close states. Good radiation characteristics of the antenna over the operating bands are also obtained. © 2008 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 2237–2242, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23636
Distinct Nutrient Intake Style in Inhabitants of Ultra-High-Altitude Areas in North of Tibet, China: A Cross-Sectional Study Based on Newly Developed Tibetan Food Frequency Questionnaires

Dietary pattern is quite distinct among the inhabitants of high-altitude areas because of environmental and geographical uniqueness; hence, it is important to investigate this data as accurately as possible. However, very few data are related to these populations up to now. Based on the food frequency questionnaire (FFQ) used in the Chinese population, a revised Tibetan edition was developed with respect to the lifestyle in high-altitude areas. After assessment of validity and reproducibility, a nutrition intake survey was conducted among 1,071 randomly sampled Tibetan people. In addition, the Bland–Altman approach was used to compare the agreement between the two dietary tools. For the reproducibility analysis, intraclass correlation coefficients (ICC) were calculated to examine the agreement of food groups and nutrients from the two FFQs (FFQ1 and FFQ2). Nutrient intake was calculated using food composition tables. For the validity analysis, Pearson's correlation of food groups intakes varied from 0.22 to 0.91 (unadjusted). The correlations of nutrients ranged from 0.24 to 0.76 (unadjusted). In the analysis of reliability, the ICC of food groups varied from 0.27 to 0.70 (unadjusted). The ICC of nutrient intakes ranged from 0.22 to 0.87 (unadjusted). The results of nutritional analysis showed that ~25% of foods consumed frequently were traditional Tibetan foods. However, traditional Han foods were frequently consumed. In addition, the energy, iron, and protein intakes for male or female subjects were close to the Chinese Dietary Nutrient Reference Intake (Chinese DRIs); however, fat and sodium intakes were significantly higher than the Chinese DRIs. Interestingly, lower intakes of other types of nutrition, such as vitamin C were detected in people living in high-altitude areas. Our data indicated that excess consumption of fat and sodium and insufficient intake of vitamin C were common among Tibetan people, as compared with the most Chinese people living in the plateau areas. More investigations are needed to reveal the association between the food intake style and high-altitude endemic diseases.
Predicting Forefoot-Orthosis Interactions in Rheumatoid Arthritis Using Computational Modelling

Foot orthoses are prescribed to reduce forefoot plantar pressures and pain in people with rheumatoid arthritis. Computational modelling can assess how the orthoses affect internal tissue stresses, but previous studies have focused on a single healthy individual. This study aimed to ascertain whether simplified forefoot models would produce differing biomechanical predictions at the orthotic interface between people with rheumatoid arthritis of varying severity, and in comparison to a healthy control. The forefoot models were developed from magnetic resonance data of 13 participants with rheumatoid arthritis and one healthy individual. Measurements of bony morphology and soft tissue thickness were taken to assess deformity. These were compared to model predictions (99th% shear strain and plantar pressure, max. pressure gradient, volume of soft tissue over 10% shear strain), alongside clinical data including body mass index and Leeds Foot Impact Scale–Impairment/Footwear score (LFIS-IF). The predicted pressure and shear strain for the healthy participant fell at the lower end of the rheumatoid models’ range. Medial first metatarsal head curvature moderately correlated to all model predicted outcomes (0.529 < r < 0.574, 0.040 < p < 0.063). BMI strongly correlated to all model predictions except pressure gradients (0.600 < r < 0.652, p < 0.05). There were no apparent relationships between model predictions and instances of bursae, erosion and synovial hypertrophy or LFIS-IF score. The forefoot models produced differing biomechanical predictions between a healthy individual and participants with rheumatoid arthritis, and between individuals with rheumatoid arthritis. Models capable of predicting subject specific biomechanical orthotic interactions could be used in the future to inform more personalised devices to protect skin and soft tissue health. While the model results did not clearly correlate with all clinical measures, there was a wide range in model predictions and morphological measures across the participants. Thus, the need for assessment of foot orthoses across a population, rather than for one individual, is clear.