Miracle-dz/UniFAR-FTUs huggingface dataset:
Local regulation of the coronary circulation in health and disease: role of nitric oxide and endothelin

Coronary artery disease is the leading cause of morbidity and mortality in western countries. Its pathogenesis is unknown, but involves enhanced vasoconstriction, increased interaction of platelets and monocytes with the vessel wall, as well as proliferation, migration and extracellular matrix formation of vascular smooth muscle. The endothelium lies in a strategic anatomical position between circulating blood and vascular smooth muscle cells. This supports the concept that dysfunction of these cells significantly contributes to coronary artery disease. Besides other mediators, endothelial cells are a source of nitric oxide and endothelin. Nitric oxide is a vasodilator, an inhibitor of both platelet function and proliferation and migration of vascular smooth muscle. Endothelin is a potent vasoconstrictor that facilitates proliferation. Under pathological conditions, in particular the presence of cardiovascular risk factors, endothelial dysfunction occurs and is a major contributor to the increase in platelet vessel wall interaction, vasoconstriction and proliferation in the coronary system. Endothelium-dependent vasodilation is usually reduced and endothelium-dependent constrictor responses, as well as endothelin production, are augmented. Hence, endothelial cells are important targets and mediators of coronary artery disease.
Soil organic carbon in no-tillage systems of different ages in Southwest Mato Grosso, Brazil1

The objectives of this study were to evaluate the effect of the no-tillage system on soil bulk density, soil organic carbon, and carbon stocks in Plinthic subgroups and Oxisols, located in Pontes and Lacerda, State of Mato Grosso, Brazil. The treatments were native vegetation and no-tillage systems established for 3, 8, 10, and 12 years. To analyse soil organic carbon, soils were sampled in each area, with three repetitions, at layers of 0-0.05; 0.05-0.10; 0.10-0.20; 0.20-0.40; 0.40-0.60; 0.60-1.00; 1.00-1.50 and 1.50-2.00 m. For soil bulk density, undisturbed samples were collected at layers of 0-0.20 and 0.20-0.40 m. Compared with areas of native vegetation, soil bulk density values after 12 years increased by 25% in Oxisols and 30% in the Plinthic subgroups. In Oxisols and Plinthic subgroups, respectively, organic carbon concentration was, on average, 20.57, 25.04 g kg-1 under native vegetation; 16.82, 16.59 g kg-1 after 3 years of no-tillage; 13.31, 4.96 g kg-1 after 8 years; 16.52, 14.39 g kg-1 after 10 years; and 17.97, 18.53 g kg-1 after 12 years. In both soils, the no-tillage system contributed to an increase in carbon stocks over the years, but not at depth, being generally limited to the top 0.20 m of the soils. Compared to native vegetation, after 12 years of no-tillage, carbon stocks decreased at a rate of 0.075 Mg ha-1 year-1 in the Plinthic subgroups and increased by 2.3 Mg ha-1 year-1 in Oxisols.
Democracy, open source and music education? A Deweyan investigation of music education in digital domains.

Music has not been solely temporal for more than a century, and musical performance has not been created exclusively in real time by humans since the piano roll entered the stage in the late 19 century (Brown, 2007). The mechanical, and later the digital, music industry has changed music as a social phenomena, increasing the availability of music to listen to, tools to create music with as well as distributional and communicational aspects of music. Music consummation happens either through live music as it always has, or through a recordings which today are mostly digital.
VALIDATIÓN OF ANALYTICAL METHOD BY UV SPECTROPHOTOMETRIC QUANTIFICATION OF GEMFIBROZIL

The present study aims to validate an analytical method by UV spectrophotometric for the quantification of gemfibrozil incorporated into microemulsions. Experimental development by constructing a ternary phase diagram for the identification of microemulsions. The characterization of the microemulsions was 1 Universidad de Guayaquil, Facultad de Ciencias Químicas, Guayaquil, Ecuador. (mariaelizabethherreraparedes@gmail.com; josecantossc@gmail.com; kevinjoelmuoz25@hotmail.es; *correspondência: fernandakolenyak@outlook.com) 2 Universidade Estadual Paulista (UNESP), Instituto de Química, Departamento de Química Analítica, Araraquara, SP, Brasil (alonso.jdr@gmail.com;) 3 Pontificia Universidad Católica del Ecuador, Facultad de Ciencias Exactas y Naturales, Escuela de Química, Quito, Ecuador (julio_vinueza@hotmail.com)
1 Choice Architecture : A Mechanism for Improving Decisions While Preserving Liberty ?

Extensive research in the social sciences has shed light on two important phenomena. One is that human decision-making is full of predicable errors and biases that often lead individuals to make choices that defeat their own ends. For example, individuals incorrectly predict what will make them happy in the future and are biased towards short-term consequences over longterm ones despite attaching more importance to their long-term goals. Let us call this the “bad choice phenomenon. ” The second phenomenon is that individuals’ decisions and behaviors are powerfully shaped by their environment in logically irrelevant ways; they are impacted by the order in which options are presented, or tone in which they are presented, and even the smell in the room. Let us call this the “influence phenomenon. ”
CCL25 and CCL28 promote (cid:1) 4 (cid:2) 7 -integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear ﬂow

and CCL28 promote (cid:1) 4 (cid:2) 7 -integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear ﬂow. Am J Physiol Gastrointest Liver Physiol 294: G1257–G1267, 2008. bowel disease is characterized by the recruitment of lymphocytes to the gut via mucosal vessels. Chemokines are believed to trigger (cid:1) 4 (cid:2) 1 - and (cid:1) 4 (cid:2) 7 -integrin-mediated adhesion to vascular cell adhesion molecule-1 (VCAM-1) and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) on mucosal vessels, although the contribution of each pathway and the chemokines involved are not well characterized. These interactions occur under conditions of hemodynamic shear, which is critical in determining how lymphocytes integrate chemokine signals to promote transmigration. To deﬁne the role of speciﬁc chemokines in mediating lymphocyte adhesion to VCAM-1 and MAdCAM-1, we studied the ability of immobilized chemokines to activate adhesion of human lymphocytes in a ﬂow-based adhesion assay. Adhesion to immobilized MAdCAM-1 was (cid:1) 4 (cid:2) 7 dependent, with no contribution from (cid:1) 4 (cid:2) 1 , whereas (cid:1) 4 (cid:2) 1 mediated rolling and static adhesion on VCAM-1. Immobilized CC-chemokine ligand (CCL) 25 and CCL28 were both able to trigger (cid:1) 4 (cid:2) 7 -dependent lymphocyte arrest on MAdCAM-1 under shear, highlighting a potential role for these chemokines in the arrest of lymphocytes on postcapillary venules in the gut. Neither had any effect on adhesion to VCAM-1, suggesting that they selectively trigger (cid:1) 4 (cid:2) 7 -mediated adhesion. Immobilized CCL21, CCL25, CCL28, and CXC-chemo-kine ligand (CXCL) 12 all converted rolling adhesion to static arrest on MAdCAM-1 by activating lymphocyte integrins, but only CCL21 and CXCL12 also triggered a motile phenotype characterized by lame-lipodia and uropod formation. Thus (cid:1) 4 (cid:2) 1 /VCAM-1 and (cid:1) 4 (cid:2) 7 /MAd-CAM-1 operate independently to support lymphocyte adhesion from ﬂow, and chemokines may act in concert with one chemokine triggering integrin-mediated arrest and a second chemokine promoting motility and transendothelial migration.
PEDRO MIGUEL XAVIER NUNES TOXICITY ASSESSMENT OF METALLIC NANOPARTICLES ON AQUATIC BIOTA AVALIAÇÃO DA TOXICIDADE DE NANOPARTÍCULAS METÁLICAS EM BIOTA AQUÁTICO DECLARAÇÃO

The recent increase in the use of nanomaterials in the day-to-day context, is due to the emergence and development of the nanotechnology from the mid1980s when their bases began to be established. From this point onwards, there was a great interest of the scientific community to explore this new type of material with interesting and promising properties, given its high resistance, reduced size, anti-microbial properties, ease of synthesis, among many others. With advances in this field, these materials have become of common usage and now have multiple applications not only in the most varied fields of science, but also in practical life, where they began to integrate personal hygiene products, containers, infrastructures, food and even part of biomedical techniques in the treatment of cancer or in simple MRI scans. In this context, this study aimed at evaluating the influence of chemical composition and coating in the ecotoxicity of iron superparamagnetic nanoparticles (NPs) to freshwater biota. For this, two iron NPs coated with dopamine were selected to be studied: iron (II) selenide (Fe3Se4@Dopa) and iron (II) oxide (Fe3O4@Dopa). To assess the influence of coating in the toxicity of NPs, Fe3Se4 was also produced with levadopamine as a coating agent (Fe3Se4@Levodopa). For each of the NPs the following toxicity assays were carried out: 72-hour growth inhibition assay with the green alga Raphidocellis subcapitata, 7-day growth inhibition assay with the macrophyte Lemna minor, 24-hour mortality assay with rotifer Brachionus calyciflorus, 72-hour mortality and feeding inhibition with the cnidarian Hydra viridissima, and 96-hour embryo development assay with Xenopus laevis. No clear pattern of toxicity was observed in the tested nanoparticles. Per example, nanoparticles presenting less toxicity for the microalgae and hydras were the Fe3Se4@Levodopa ones, but this was the NP most toxic for L. minor. The species presenting higher sensitivity for all three tested nanoparticles was the rotifera B. calyciflorus, exhibiting significant mortality in concentrations of 17.6 mg/L. Although there is no information in scientific literature on expected concentrations of the NPs occurring in surface waters, based on previsions performed on other nanoparticles used more commonly in human products, it is expected that concentrations that induced effects on the present study (in orders of mg/L) are far above those that may occur in the environment in the near future.
In vitro behavior of Fusarium spp . isolates in differents cultivations conditions Comportamento in vitro de isolados de Fusarium spp . em diferentes condições de cultivo

Ananas comosus (L) Merril var. comosus is the most important fruit segment in Brazil. In Paraíba, the occurrence of fusariosis is associated with humidity, light and temperature, important factors for the reproduction and dissemination of Fusarium spp. The aim of the study was to evaluate mycelial growth and sporulation of F. spp. under different cultivation conditions. The 10 isolates were grown at different temperatures, luminosities and a Potato Dextrose Agar (PDA) culture medium. Mycelial growth was measured with a ruler graduated in centimeters (cm), at 24-hour intervals, for six days. Conidial production was also quantified with the aid of a Neubauer chamber (x 10 conidia/mL). The design was completely randomized in a factorial arrangement (3x3x10) and 15 repetitions. The averages were compared by Scott-Knott (p ≤ 0.05) in the statistical program R. At temperatures of 15 and 35 °C, in all light regimes, there was no stimulus for the production of mycelial when the ten isolates were evaluated, with the exception of the temperature of 35 °C, in the alternating light regime, which obtained. At a temperature of 25 °C, isolates 5 and 10 stood out from the others in the mycelial growth of F. spp. , with isolates that produced low and medium mycelium production. For the production of conidia, the temperature of 15 °C, in the three light regimes, a small production of conidia (x 10/mL) was observed, at the temperature of 25 °C in the light and continuous dark regimes, there was a greater production of conidia (x 10/mL) in isolates 5 and 20 in relation to the other isolates, already in the alternating light regime, all isolates obtained a high production of conidia (x 10/mL). At a temperature of 35 °C, with continuous light and dark regimes and alternating light for isolates 1, 2, 3, 4 and 7, they presented an average production, whereas isolates 5, 6, 8, 9 and 19 obtained high productions conidia (x 10/mL) of F. spp. The recommended culture conditions for mycelial growth and multiplication of Fusarium spp. are the alternating light regime and temperature of 25 °C.
Self-Directed Summer Design Experience Across Disciplines and the Globe

During the summer of 2014, the Harvard School of Engineering and Applied Sciences and the Hong Kong University of Science and Technology initiated a multidisciplinary international design experience for the benefit of the student populations of both institutions. The goal of this program was to create an international multidisciplinary team-based research and design project that included exposure to the academic and industrial environments in both Hong Kong as well as the United States (specifically the Boston area). The Harvard-HKUST International Summer Design Experience occurred completely outside of any classroom setting during nine weeks and was co-located in Boston and Hong Kong for four weeks each. The reason to hold this program in both Hong Kong and Cambridge, MA was to give the students a chance to work within and experience both campuses, culturally and geographically. The pedagogical approach was unique, as there was no embedded curriculum and students were able to freely pursue a project in a given topic area that they were interested in. The major topic for this summer was Visible Light Communication systems. In this paper we present the general pedagogical approach to this experience and provide some insights and examples of the effect the program had on students.
Coordination between Stomatal Conductance and Leaf ‒ speciﬁc Hydraulic Conductance in Maize ( Zea mays L.)

Field experiments were conducted on August 10 and 11 during the summer of 2004 in a maize ﬁeld to investigate the correlation between stomatal conductance and leaf ‒ speciﬁc hydraulic conductance. During these two days, stomatal conductance, transpiration rate, volumetric soil water content and leaf water potential were measured independently. Leaf ‒ speciﬁc hydraulic conductance was calculated by the transpiration rate and the water potential difference between soil and leaf. The measured data were checked according to their diurnal variations and their respective standard deviations among samples. Results show that a strong positive correlation exists between leaf stomatal conductance and leaf ‒ speciﬁc hydraulic conductance (r 2 =0.66 and 0.74, respectively on each day). Leaf ‒ speciﬁc hydraulic conductance was strongly and positively correlated to transpiration rate on these two days (r 2 =0.87 and 0.84,respectively). The probable reasons explaining the relationship between hydraulic conductance and stomatal conductance are discussed. It is concluded that their respective relationship to transpiration rate cause the coordination between stomatal conductance and leaf ‒ speciﬁc hydraulic conductance under the condition of no soil water stress. These results are expected to: (1) improve models involving plant gas exchange by incorporating the hydraulic constraints into these models; currently, most models do not take explicit account of plant hydraulics; and, (2) provide a new insight on the mechanism of hydraulic constraints on stomatal conductance and on related plant gas exchange, and hence enforce our understanding on SPAC water relations.
Voltage and frequency dependence of tree growth in polyethylene

Accelerated life tests of polymer insulation is used to get rapid life distribution data. Low-density polyethylene (DED 2005) used as the specimen was heated for 15 min at 130°C. A needle electrode was then inserted into the specimen. The needle tip was ground to an angle of 30° and a radius of curvature of 5 μ. The arrangement of electrodes in the specimens is shown in Fig. 1. The test frequencies were 50, 300, 1000, 3000, and 10,000 Hz.
Adsorption of Fluoxetine and Venlafaxine onto the Marine Seaweed Bifurcaria bifurcata

Marine macroalga Bifurcaria bifurcata was investigated as sorbent for two environmental emerging pollutants, the pharmaceuticals venlafaxine (VLF) and fluoxetine (FLX), from aqueous solutions, both in mono and bicomponent batch systems. The alga was characterized by means of IR spectroscopy, allowing to identify the most important groups for biosorption, carboxylic, sulfonic and hidroxile. The point of zero charge was determined, being 6.4. Adsorption of FLX follows a pseudo first order kinetics and kinetic constants are higher for FLX than for VLF. Its adsorption better represented by the pseudo second order model. For both pharmaceuticals, the equilibrium was reached within *100 min. Adsorption studies reveal that the process was more efficient at lower pH range and followed the Langmuir–Freundlich’s model for VLF and Langmuir’s model for FLX. Maximum adsorption capacities reached a level of 12 – 3 and 22 – 4 lmol/g for VLF and FLX, respectively, in the mono-component system. The difference was attributed to the presence of various functional groups of varying polarity within the adsorbates’ molecules that affected their interactions with the adsorbent surface. The Langmuir–Freundlich’s extended model was applied to the adsorption data of the bicomponent system and no changes in the maximum adsorption capacities were found (14 – 2 and 20 – 3 lmol/g for VLF and FLX, respectively), there is no evidence of competition between the adsorbates.
High-rate multi-GNSS attitude determination: experiments, comparisons with inertial measurement units and applications of GNSS rotational seismology to the 2011 Tohoku Mw9.0 earthquake

High-rate GNSS positioning has been widely investigated and applied in science and engineering. We extend it to high-rate attitude determination under a multi-GNSS constellation. A series of experiments of high-rate GNSS attitude determination has been conducted on a platform with three 50 Hz geodetic receivers and two high-grade inertial measurement units (IMU). The high-rate attitude solutions are computed for each of the multi-GNSS systems and the combined constellation by either using short baselines with correct ambiguity resolution or precise point positioning (PPP) and compared with the IMU measurements. In the case of a single GNSS system, the experimental results have shown that GPS is of the best accuracy, followed by GLONASS. The results with Beidou are the noisiest. The combined multi-GNSS constellation can significantly improve the high-rate attitude solutions from any single GNSS system alone, which is, in particular, most suitable for applications to any platform in slow or quasi-static motion. However, the improvement rate could depend on proper weightings of measurements from different GNSS systems in the dynamical experiments. The accuracy of baseline-based high-rate GNSS attitude solutions remains stable over time, while that of PPPbased solutions substantially degrades with time, as theoretically expected. Within a short period of time, the PPP-based high-rate yaw solutions with the combined multi-GNSS constellation are comparable in accuracy with those computed from baselines with correct ambiguity resolution in the dynamical experiments. The attitude results from either static or dynamical experiments have shown that high-rate GNSS attitude determination is sufficiently precise to measure rotatory motions. GNSS rotational seismology is applied to the 2011 Tohoku Mw9.0 earthquake, illustrating the potential of multi-GNSS to precisely detect seismic rotatory motions.
Financial technologies trends and the way they will shape financial markets

Today fintech research is among trending topics by international scholars. Abundance of research in this sphere causes state of infobesity for users. Goal of the research is to organize research findings and reveal general trends in fintech that can be applied to fintech sphere classified to segments depending on technologies used. Research work covers fintech areas such as: Innovation labs, Platform business, Cloud solutions, Anti Money Laundering, Know Your Customer, Blockchain, Regulatory technologies and Big Data. First, definition of fintech is discussed and fintech opportunities are analysed. Second, those fintech trends are generalised. As a result seven general trends revealed: Financial markets in pursue of blockchain benefits in speed and wealth management, Regulation and RegTech solving compliance issues, All parties want to master big data, Participants of Fintech industry investing more in Innovation labs, Opportunity cost of acquiring cloud solutions decreasing, fintech industry players consolidating and collaborating, Fintech developers providing platforms for fintech developers, More and more cognitive computing is used in financial services, Automatization of Know Your Customer internal processes and Anti Money Laundering.
BOSCIA ALBITRUNCA : REVIEW OF ITS BOTANY, MEDICINAL USES, PHYTOCHEMISTRY, AND BIOLOGICAL ACTIVITIES

Boscia albitrunca is a medium-sized tree widely used as herbal medicine in Southern Africa. The current study critically reviewed the botany, medicinal uses, phytochemistry, and pharmacological activities of B. albitrunca . Literature on botany, medicinal uses, phytochemical, and biological activities of B. albitrunca was collected from multiple internet sources including Elsevier, Google Scholar, SciFinder, Web of Science, PubMed, BMC, Science Direct, and Scopus. Complementary information was gathered from pre-electronic sources such as books, book chapters, theses, scientific reports, and journal articles obtained from the university library. This study revealed that the species is used as herbal medicine in 75.0% of the countries in Southern Africa where the species is indigenous. The bark, leaves, and roots of albitrunca are mainly used as herbal medicines for constipation, epilepsy, hemorrhoids, headache, human immunodeficiency virus/acquired immune deficiency syndrome, skin diseases, syphilis, and as ethnoveterinary medicine. Ethnopharmacological research identified phenolic compounds, alkaloids, coumarins, flavonoids, saponins, steroids, tannins, and triterpernoids from leaves of B. albitrunca. The crude extracts of the species and the compound martynoside isolated from B. albitrunca exhibited antibacterial and antifungal activities. B. albitrunca should be subjected to detailed phytochemical, pharmacological, and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological activities.