Miracle-dz/UniFAR-FTUs huggingface dataset:
Deregulation of Polycomb Repressive Complex-2 in Mantle Cell Deregulation of Polycomb Repressive Complex-2 in Mantle Cell Lymphoma Confers Growth Advantage by Epigenetic Suppression Lymphoma Confers Growth Advantage by Epigenetic Suppression of of

The polycomb repressive complex 2 (PRC2) maintains the transcriptional repression of target genes through its catalytic component enhancer of zeste homolog 2 (EZH2). Through modulating critical gene expression, EZH2 also plays a role in cancer development and progression by promoting cancer cell survival and invasion. Mutations in EZH2 are prevalent in certain B-cell lymphoma subtypes such as diffuse large cell lymphoma and follicular lymphoma; while no EZH2 mutation has been reported in the mantle cell lymphoma (MCL). Here we demonstrate that the PRC2 components EZH2, EED and SUZ12 are upregulated in the MCL cells as compared to normal B-cells. Moreover, stably transfected cells with wild-type EZH2 or-EED showed increased cell growth and H3K27-trimehtylation. However, unlike wild-type EZH2, ectopic expression of a deletion construct of EZH2 (EZH2 1 550 − 738 lacking SET domain) had no growth advantage over control cells. Pharmacological inhibition of EZH2 suppressed H3K27me3 and had signiﬁcant inhibitory effect on cell growth and colony forming capacity ( p < 0.05) of MCL cells, and this effect was more or less comparable to the anti-proliferative effects of EZH2 inhibition in cells harboring EZH2-mutation. Mechanistically, EZH2 appears to downregulate expression of cdkn2b gene via enhanced H3K27me3, a well-known suppressive epigenetic mark, at the cdkn2b promoter region. Overall, these results highlight that deregulation of PRC2/EZH2 is associated with epigenetic suppression of cdkn2b in MCL, and in part responsible for increased cell growth, thus the EZH2 inhibitors may have therapeutic potential in the patients with MCL.
The Temporal and Spatial Patterning of the Initial Settlement of Sāmoa

ABSTRACT Among the Lapita-bearing island groups of the Pacific, Sāmoa is unusual for having a relatively large land area but only one cultural deposit containing Lapita ceramics. Although it has been proposed that additional Lapita settlements may have been distributed along the coasts of much of the archipelago, investigations have not located these deposits nor reliably dated early Polynesian Plainware deposits older than ∼2500 cal BP. We combine a chronometric hygiene protocol and a GIS-based model of the paleoshoreline to examine the temporal and spatial distribution of pre-2000 cal BP archaeological deposits in the islands. Using the currently available suite of radiocarbon dates, it is apparent that only by ∼2300–2000 cal BP were a number of settlements occupied across the archipelago. Acknowledging that a variety of geomorphological processes have changed the Sāmoan landscape, we developed a GIS-based model of the ∼3000 cal BP coastlines of Tutuila and Aunu’u Islands, which suggest that suitable sandy coastal flats had not formed in many areas prior to ∼2500 cal BP, hence limiting settlement by Lapita peoples. Our methodology, which combines an evaluation of early radiocarbon dates with a GIS-based paleoshoreline model, offers a valuable means of incorporating temporal and spatial data for the examination of coastal and island colonization.
Oxygen fugacity of basaltic magmas and the role of gas-forming elements

It is suggested that major variations in the relative oxygen fugacity of a basaltic magma are caused primarily by gas-forming elements, especially carbon and hydrogen. According to this theory, carbon, present in the source region of a basaltic magma, reduces the host magma during ascent, as isothermally carbon becomes more reducing with decreasing pressure. For an anhydrous magma such as lunar basalts, this reduction continues through the extrusive phase and the relative oxygen fugacity decreases rapidly until buffered by the precipitation of a metallic phase. For hydrous magmas such as terrestrial basalts, reduction by carbon is eventually superceded by oxidation due to loss of H2 generated by the reaction of C with H2O and by thermal dissociation of H2O. The relative oxygen fugacity of a hydrous magma initially decreases as a magma ascends from the source region and then increases until magnetite crystallization curbs the rising trend of the relative oxygen fugacity.
OLED Screens Better Exhibit the Color Black than LCD Screens

We performed an experiment to determine the amount of light emitted from screens in order to assess the ability of organic light emitting diode screens (OLED) and liquid crystal display (LCD) screens to display the color black. These two competing screen types dominate the digital market, and the capability to exhibit black is one of many factors that should be considered when determining the better of the options. The better a screen can show black, the stronger the contrast of the screen appears to be. The mechanisms that create light within each suggest that OLED screens should be able to show the color black, while LCD screens may not. Therefore, we hypothesized that the light emitted from the LCD screen in this state would be significantly greater than in the OLED. We conducted thirty trials in an environment that eliminated all external light, allowing an accurate recording of emitted light. The results mostly supported our hypothesis: there was a significant increase in light emitted in the LCD screen compared to the OLED when both displayed identical black images at full brightness, though at minimum brightness the LCD performed with negligible difference than OLED.
Petrology of impactites from Lake St. Martin structure, Manitoba

The 23-km Lake St. Martin crater was produced 200 to 250 million years ago in Archean granitic to amphibolic gneiss, overlain by 400 to 500 m of Ordovician to Devonian limestone and dolomite. In the present paper, a schematic model of the field geology, petrology, and geochemistry is presented. The scenario is built in part on the calculations of Kieffer and Simonds and observations made on the Lake St. Martin structure.
Generation of submesoscale vortices: A new mechanism

Small-scale, intense vortices composed of water with anomalous values of quasi-conservative tracers have been observed in many oceans. They are particularly numerous in the Beaufort Gyre of the Arctic Ocean. Possible mechanisms responsible for the generation of these features are examined. Conservation of temperature, salinity, and nutrients requires that Beaufort Sea vortices be created from water that flows into the Arctic Ocean from the Pacific Ocean across the broad, shallow Chukchi Sea. Much of this water passes through Barrow Canyon, near Point Barrow, Alaska. Observations in the canyon show the generation of vortices of approximately the same size as those observed in the Beaufort Sea. Barrow Canyon is therefore a likely site for the generation of Beaufort Sea vortices. Most observed Beaufort Sea vortices have a central potential vorticity near zero because of a relative vorticity close to −ƒ. Their Chukchi Sea source water is typically stratified with little relative vorticity, so that its potential vorticity is nonzero. A key step in the generation of the vortices is therefore the reduction of the potential vorticity of Chukchi Sea water to nearly zero. It is proposed that this occurs through the action of frictional torques occurring as the Chukchi Sea water flows through Barrow Canyon, rather than througji the action of vertical mixing. Because this flow is driven by a downstream pressure gradient, it is concentrated on the right-hand wall of the canyon by the Coriolis force. The frictional torques thus preferentially reduce the potential vorticity of the fluid. Anticyclonic vortices are therefore preferentially generated. It is suggested that a similar scenario may play a role in the generation of submesoscale vortices containing water from the Mediterranean and Labrador seas.
Assessment of focal mechanisms of microseismic events computed from two three‐component receivers: application to the Arkema‐Vauvert field (France)

We have developed a method that enables computing double‐couple focal mechanisms with only a few sensors. This method is based on a non‐linear inversion of the P, Sv and Sh amplitudes of microseismic events recorded on a set of sensors. The information brought by the focal mechanism enables determining the geometry of the rupture on the associated geological structure. It also provides a better estimate of the conventional source parameters. Full analysis has been performed on a data set of 15 microseismic events recorded in the brine production field of Vauvert. The microseismic monitoring network consisted of two permanent tools and one temporary borehole string. The majority of the focal mechanisms computed from both permanent tools are similar to those computed from the whole network. This result indicates that the double‐couple focal mechanism determination is reliable for both permanent 3C receivers in this field.
Microbial Inoculantes Effects on Growth Promotion of Mangrove and Citrullus vulgaris San Andrés Isla, Colombia

In order to test the effect of two microbial inoculants (obtained from red and black mangrove roots) on the growth and stability of mangrove and watermelon plants, four treatments were carried out in San Andres Island, Colombia. The treatments consisted in the application of the inoculants in: A. germinans propagules collected in a mangrove area, and then individually planted in gavels with sun-pasteurized soil (in order to decrease the microbial load), A. germinans and R. mangle plants collected in the proximity of nursery trees, A. germinans and R. mangle planted and maintained in nursery, and in Citrullus vulgaris seeds planted in a traditional cultivar without chemical fertilizers. The growth and vegetative development variables were: number of nodes, number of leaves and steam length. The inoculants (phosphate solubilizing microorganisms -PSMand nitrogen fixing bacteria -NFB-) were applied in the mentioned vegetable material, doing measures during three months. The results show a positive effect on growth measured by steam length in plants treated specifically with the inoculants in C. vulgaris and A. germinans seedlings maintained in nursery.
Review Synthèse

to maternal use of a synthetic estrogen, diethylstilbestrol (DES), during pregnancy. Daughters of these women have an increased risk of reproductive and immunologic abnormalities, and sons are at risk of genital anomalies and abnormal spermatogenesis. 4 In animals, and possibly in humans, DES alters male-and female-typical behaviour patterns. 5 The example of DES indicates that the fetus may be at greatest risk from the adverse effects of hormonal disruption.
Demand Bidding Models for Chemical Processes: Conceptual Framework and a Chlor-Alkali Optimal Power Flow Example

In recent years, the integration of renewable energy resources has significantly increased the variability of power generation rates in the power grid. As a result, balancing power supply and demand has become more challenging. Price-based demand response programs partially address this problem in the sense that they incentivize (large) users to reduce their consumption during peak demand periods. However, the resulting load changes remain relatively unpredictable to the grid operator. Demand bidding has the potential to improve the predictability as large electricity consumers submit electricity load bids to the grid and adjust consumption during critical time intervals. In this work, we propose a demand bidding model for industrial plants and validate it using a prototype system comprising the IEEE 24 Bus reliability test case and chlor-alkali plant as the load entity.
MIE INSTAN BELALANG KAYU (Melanoplus cinereus): KAJIAN PUSTAKA [IN PRESS JANUARI 2016]

Kurang Energi Protein merupakan masalah gizi yang masih banyak terjadi di Indonesia Tercatat pada tahun 2010 prevalensi gizi kurang masih 17.90% dan sebanyak 8 juta anak balita atau 35.60% jumlah keseluruhan balita Indonesia mengalami gizi buruk kategori “ stunting ” atau tinggi badan lebih rendah dibanding balita normal. Hal tersebut terjadi karena produk olahan yang mencukupi asupan gizi protein dijual dengan harga yang cukup mahal karena sumbernya masih terbatas pada susu sapi. Di sisi lain, tingkat konsumsi mie instan di Indonesia semakin meningkat konsumsi mie instan di Indonesia merupakan kedua terbesar dunia setelah Cina. Keberadaan mie instan di Indonesia mulai menjadi makanan pokok kedua setelah beras. Selain praktis dan mudah penyajiannya, harga mie instan cukup murah dan terjangkau. Sementara belalang kayu dianggap sebagai hewan liar atau hama. Belalang dapat berpotensi sebagai sumber protein non-konvesional atau sumber protein yang belum banyak dikonsumsi oleh masyarakat sehingga perlu penelitian lebih mendalam mengenai kualitas protein yang dikandung oleh belalang. Kata Kunci: Belalang kayu, Mie instan, Protein
Investigation of the effectiveness of prone ventilation in patients followed up for acute respiratory distress syndrome in the intensive care unit.

OBJECTIVE Prone positioning has been found to improve oxygenation in most patients with acute respiratory distress syndrome (ARDS). The study aimed to investigate the effectiveness of the prone position in patients with ARDS. PATIENTS AND METHODS The prone position is one of the ventilator techniques included in recent guidelines for acute respiratory distress syndrome. This study was a retrospective evaluation of the records of 100 ARDS patients who were administered prone position mechanical ventilation in our intensive care unit. All patients were placed in the prone position for a total of 12 hours per day at 4-hour intervals (supine-prone) while admitted to the intensive care unit. RESULTS This study included 100 participants. These patients were divided into two groups as survivors [(n=38, 16 females, 22 males, median age: 60 (24-86)] and non-survivors [(n=62, 19 females, 43 males, median age: 64 (21-93)], according to their intensive care follow-ups. Acute physiology and chronic health evaluation (APACHE) II score, the sequential organ failure assessment score (SOFA), and inflammation markers were statistically significantly higher in the non-survivor group. Between the two groups, there was no statistically significant difference in terms of fundamental characteristics. In the sub-group evaluation of the subjects in patients with ARDS with and without novel coronavirus disease 2019 (COVID-19) groups, the patients in the COVID-19 (+) group were older, had shorter hospital stays, had higher APACHE II and SOFA scores, and higher rates of cardiovascular disease and sepsis. CONCLUSIONS Applying prone-position mechanical ventilation in the cohorts of our patients with ARDS resulted in a demonstrable significant improvement in the oxygenation levels of our patients.
MR Imaging Study with Arteriovenous Malformations: A Functional Plasticity of the Human Motor Cortex in Patients

BACKGROUND AND PURPOSE: The capacity of the human brain to recover from damage has been explained on the basis of plasticity, according to which remaining areas assume functions that would normally have been performed by the damaged brain. Patients with cerebral arteriovenous malformations (AVMs) involving primary motor areas may present without signiﬁcant neurologic deﬁcits. We used functional MR imaging to investigate the organization of cortical motor areas in patients with AVMs. METHODS: Cortical motor hand and foot representations were mapped in nine right-handed patients harboring AVMs occupying the hand (n (cid:53) 6) or foot (n (cid:53) 3) region of the primary motor cortex (M1). None of the patients exhibited motor deﬁcits. Simple movements of the hand and foot were performed. In eight patients, both right and left extremities were tested; in one patient, only the hand contralateral to the AVM was examined. Localization of activation in the affected hemisphere was compared with that in the unaffected hemisphere and evaluated with respect to the normal M1 somatotopic organization shown in earlier functional MR imaging investigations. RESULTS: Cortical activation showed three patterns: 1) functional displacement within the affected M1 independent of the structural distortion induced by the AVM (n (cid:53) 4), 2) presence of activation within the unaffected M1 ipsilateral to the moving extremity without activation in the affected M1 (n (cid:53) 3), and 3) prominent activation in nonprimary motor areas without activation in either the affected or unaffected M1 (n (cid:53) 2). CONCLUSION: Preliminary evidence suggests that brain AVMs lead to reorganization within the somatotopic representation in M1 and to occasional abnormal expansion into nonprimary motor areas.
related cognitive decline in cognitively normal older adults related cognitive decline in cognitively normal older adults

The non-synonymous single nucleotide polymorphism (SNP), Val158Met within the Catechol-O -methyl- transferase ( COMT ) gene has been associated with altered levels of cognition and memory performance in cognitively normal adults. This study aimed to investigate the independent and interactional e ﬀ ects of COMT Val158Met on cognitive performance. In particular, it was hypothesised that COMT Val158Met would modify the e ﬀ ect of neocortical A β -amyloid (A β ) accumulation and carriage of the apolipoprotein E ( APOE) ε 4 allele on cognition in preclinical Alzheimer ’ s disease (AD). In 598 cognitively normal older adults with known neocortical A β levels, linear mixed modelling revealed no signi ﬁ cant independent or interactional associations between COMT Val158Met and cognitive decline. These ﬁ ndings do not support previous associations between COMT Val158Met and cognitive performance and suggest this variant does not in ﬂ uence A β -amyloid or APOE ε 4 driven cognitive decline in a well characterised cohort of cognitively normal older adults.
Measuring Images of Foreign Products

This paper presents a method for measuring country-level images for products. The method, which requires onty ordinally sealed data and produces more efficient estimates than simple averages, is applied to American skiers' images of European ski-vacations. The results indicate that the images of Switzerland, Austria, and France are relatively homogeneous with Switzerland and slightly more positively viewed than that of France.
An efficient approach to automated geometry diagram parsing

An automated geometry problem solver can be a valuable tool in math education as a learning aid. An essential part of such a system is the ability to parse diagrams automatically, and diagram understanding by itself is an interesting research problem because of the rich and complex information that geometry diagrams convey and the many approaches one can take to extract that information. In this paper, we introduce Fast Geometry Diagram Parser (FastGDP), an efficient approach to geometry diagram understanding that uses clustering and corner information. We hypothesized that FastGDP would be significantly faster than the widely used GeoSolver tool at both primitive (line and circle) and point detection, because FastGDP does not require large numbers of computationally expensive pixel-level calculations. We further hypothesized that FastGDP would offer comparable performance to GeoSolver on point detection, due to FastGDP’s use of corner information. We expected FastGDP’s primitive detection performance to be marginally lower than that of GeoSolver due to the latter’s emphasis on over-generation of primitives and subsequent selection of the best detections. Our experiments on three datasets (combined n=169) showed that FastGDP is more than an order of magnitude faster than GeoSolver in most cases. We found that FastGDP reports comparable performance to GeoSolver on primitive detection and slightly lower performance on point detection. We believe that the speed advantage offered by FastGDP will provide greater flexibility when it is incorporated into an automated geometry problem solver, especially if FastGDP is used within the training loop of the solver.
ARE FISH PRIMARILY STROKE VOLUME-MODULATORS? NOT ACCORDING TO CENTRARCHIDS

In most animals, physical or chemical stressors usually elicit an increase in metabolic rate and consequently an increase in cardiac output and one or both of its components, heart rate and stroke volume. While mammals and birds primarily increase cardiac output through the elevation of heart rate (frequency modulation), fish are generally thought to increase cardiac output principally through changes in stroke volume (volume modulation). It has even been suggested that among vertebrates there is an evolutionary trend from volume-modulated to frequency-modulated cardiac output. Within fish, only a few species have been regarded as frequency-modulators including the highly active tuna and the Antarctic nototheniids. In an effort to expand our comprehension of cardiac function in fish, we collected data on several species from two common families, Salmonidae and Centrarchidae, under various conditions. Our preliminary findings indicate that frequency modulation is more prevalent than previously thought especially among centrarchids.
Nutritional intervention for the prognosis of nasopharyngeal carcinoma chemoradiotherapy patients: A meta-analysis

Background: To conduct a meta-analysis to investigate the effects of different nutritional interventions on various serum nutritional indicators and patients’ prognosis during radiotherapy for nasopharyngeal carcinoma, to assess treatment safety and efficacy. Methods: A systematic literature search, mainly randomized controlled trials (RCTs), on the effects of nutritional support on patients undergoing radiotherapy for nasopharyngeal carcinoma was conducted between January 2010 and August 2022 using databases such as China National Knowledge Infrastructure, Wanfang Database, Web of Science, PubMed, Cochrane Library, and Embase. Risk of bias was assessed using the Cochrane Rob2 scale. The meta-analysis was performed using Stata 17.0 software, and the heterogeneity between studies was assessed using the I2 test, and funnel plots were used to qualitatively assess publication bias. Results: Overall, 10 RCTs with a total sample size of 879 cases were identified. The meta-analysis results showed that body mass index (BMI) (odds ratio = 0.026, 95% confidence interval[1]: −0.348 to 0.401, P > .05), albumin (standardized mean difference [SMD] = 0.13, 95% CI: −0.127 to 0.387, P > .05), and total protein levels were not significantly different between the nasopharyngeal cancer (NPC) radiotherapy group with nutritional support group (SMD = −0.262, 95% CI: −1.062 to 0.537, P > .05) and the control group; pre-albumin (SMD = 0.256, 95% CI: 0.022–0.491, P = .032), hemoglobin (SMD = 0.436, 95% CI: 0.26–0.612, P < .000), and lymphocyte count (SMD = 1.125, 95% CI: 0.868–1.381, P < .000) were significantly higher in the nutritional intervention group than in the control group. Conclusion: Compared with conventional diets, nutritional interventions can improve serum nutritional parameters, nutritional status, treatment tolerance, and prognosis of patients undergoing radiotherapy for nasopharyngeal carcinoma.