Miracle-dz/UniFAR-FTUs huggingface dataset:
Benzodiazepines and z-drugs - between treatment effectiveness and the risk of addiction

Benzodiazepines (BZDs) and Z-drugs are commonly prescribed medications for anxiety and sleep disorders. This review examines their efficacy, associated risks, and alternative treatment options. BZDs enhance the activity of gamma-aminobutyric acid (GABA), reducing anxiety, while Z-drugs selectively target GABA-A receptors' alpha-1 subunits for sedative effects. Despite their effectiveness, both drug classes carry the risk of addiction, physical and psychological dependence, and withdrawal symptoms. Side effects, such as drowsiness, dizziness, and cognitive impairment, are also associated with their use. Recent studies indicate that chronic use of BZDs and Z-drugs may lead to cognitive impairment and an increased risk of dementia in older adults. Furthermore, individual factors, dosage, duration of use, and drug interactions can affect their efficacy. Prescribing trends show a decline in benzodiazepine prescriptions and an increase in Z-drug use due to perceived safety advantages. However, evidence suggests that Z-drugs carry similar risks of adverse effects and addiction potential as benzodiazepines. Healthcare professionals should carefully assess patients before prescribing these drugs and monitor their use to prevent dependence and addiction. Brief interventions, patient education, drug withdrawal support, and cognitive behavioral therapy have shown effectiveness in reducing long-term benzodiazepine and Z-drug use. Alternative treatments, including cognitive behavioral therapy and relaxation techniques, should be considered, particularly for patients with a history of addiction or those at high risk of addiction. In conclusion, the risk of addiction, withdrawal symptoms, and adverse effects associated with benzodiazepines and Z-drugs necessitates cautious prescribing and the exploration of alternative treatment options.
Snake venom detoxification potential of selected Nigerian medicinal plants: a review

Snake envenomation is one of the neglected public health problems with high morbidity and mortality rate across the globe. Snakebite has led to several major health complications such as numbness and flaccid paralysis, damage to local tissue which eventually results in temporary and/or permanent physical impairment. In Nigeria however, lack of access to emergency treatment for snake envenomation has in no small measure contributed to the high rate of snake incidence. Though, a lot of drawbacks and limitations associated with the use of standard antisnake venom (ASV) include storage, side effects, expire in short time coupled with short supply. These factors made snake venom detoxification with ASV unaffordable to victims especially to people living in rural areas who are at high risk of snakebites. Therefore, the use of medicinal plants remains the only alternative for snake venom detoxification (SVD) in Nigeria especially in rural areas. This mini review reported the detoxification potentials of different medicinal plants (parts: leaves, stem bark, root, seed) of creeping foxglove (Asystasia gangetica L.), Resurrection plant (Bryophullum pinnatum Lam), Hammattan lily (Crinum jagus) wild custard apple (Annona sengalensis), plantain (Musa paradiasia) and finger root (Uvaria chamate), used to treat snakebite in Nigeria. Majority of these medicinal plants used by herbalists were validated by recent scientific works conducted on snake venom detoxification potentials. Bioactive antivenin compounds such as aristolochic acid, quercetin, kaempferol, resveratrol isolated from common Nigerian medicinal plants show very promising detoxification potential against snakebites. The authors of this review paper suggest that, more ethnomedicinal survey should be done to explore more plants with SVD potential for the development of effective medications.
RecMon: A Deep Learning-based Data Recovery System for Network Monitoring

Network monitoring systems struggle with the issue that the measurement data is incomplete, with only a subset of origin-destination (OD) pairs or time slots observed, due to the high deployment and measurement cost. Recent studies show that the missing data can be inferred from partial measurements using neural network models and tensor methods. However, these recovery approaches fail to achieve accuracy, adaptability and high speed, simultaneously. In this paper, we propose RecMon, a deep learning-based data recovery system that satisfies the above three criteria. A global spatio-temporal attention mechanism and a data augmentation algorithm are proposed to improve the recovery accuracy. A semi-supervised learning-based scheme is devised for fast and effective model updates. We conduct extensive experiments on three real-world datasets to compare RecMon with four state-of-the-art methods in terms of online recovery performance. The experimental results show that RecMon can adapt to the latest state of the network and accurately recover network measurement data in less than 100 milliseconds. When 90% of the data is missing, the recovery accuracy of RecMon improves over the strongest baseline method by 22.7%, 16.0%, and 8.2% in the three datasets, respectively.
Study on Optimal Extraction and Hypoglycemic Effect of Quercetin

Quercetin was extracted from Portulaca oleracea L. through biphasic acid hydrolysis to investigate its potential as a suppressor of dipeptidyl peptidase IV (DPP-IV) and its hypoglycemic effect in type 2 diabetic mice. The extraction procedure was optimized utilizing the response surface method (RSM) in a single-factor experimental setting. An extraction efficiency of 0.675% was achieved using the following optimized parameters: 0.064 mol/L vitriol, 1 : 109.155 solid-liquid ratio, and 21.408 min ultrasonication. Overall, findings indicate the effectiveness of quercetin extraction. A mouse model for type 2 diabetes was established to receive oral treatment with various quercetin concentrations for 8 weeks. Fasting blood glucose (FBG) and the DPP-IV activity in the serum were significantly reduced. The weight and insulin levels of the mice in the quercetin group were raised compared to those in the model group (P < 0.01). Quercetin dose-dependently inhibited postprandial blood glucose excursions, as demonstrated by the oral glucose tolerance test. These results confirmed that quercetin has hypoglycemic effects and considerably improves insulin sensitivity via DPP-IV targeting.
Genes associated with ant social behavior show distinct transcriptional and evolutionary patterns

Studies of the genetic basis and evolution of complex social behavior emphasize either conserved or novel genes. To begin to reconcile these perspectives, we studied how the evolutionary conservation of genes associated with social behavior depends on regulatory context, and whether genes associated with social behavior exist in distinct regulatory and evolutionary contexts. We identified modules of co-expressed genes associated with age-based division of labor between nurses and foragers in the ant Monomorium pharaonis, and we studied the relationship between molecular evolution, connectivity, and expression. Highly connected and expressed genes were more evolutionarily conserved, as expected. However, compared to the rest of the genome, forager-upregulated genes were much more highly connected and conserved, while nurse-upregulated genes were less connected and more evolutionarily labile. Our results indicate that the genetic architecture of social behavior includes both highly connected and conserved components as well as loosely connected and evolutionarily labile components. DOI: http://dx.doi. org/10.7554/eLife.04775. 001
Transformation or deformation? Ghana's Bui hydropower dam and the myth of modernity of the resettlement camps

ABSTRACT The Bui Dam is a consequential infrastructure undertaking in modern Ghana. The project is Ghana's third large dam and the second largest by total installed capacity. In addition to addressing a crippling national energy crisis, proponents touted the project's high modernist imperatives, including industrialisation and rural development. These benefits were promoted to counteract resistance by surrounding communities who opposed the project. However, after an involuntary resettlement programme overseen by Ghanaian authorities, resettlers now feel the reality of their acquiescence. Resettlers’ declining quality of life and harsh living conditions coupled with several unmet promises underline the dissonance between rhetoric and reality. Using modernisation framework, this study evaluates the dam's post-resettlement challenges and argues that missteps, poor planning, failed promises, and neglect have combined to unleash hardships on resettlers. The study stresses adherence to pre- and post-dam planning procedures in ensuring sustainability and justice for dam-affected populations.
An Improved Direction-of-Arrival Estimation Method Using Atomic Norm Minimization Algorithm Based on Support Set of Sparse Vectors

The compressed sensing-based direction of arrival (DOA) estimation method with high precision and fewer snapshots has garnered attention. However, existing studies decrease in accuracy significantly as the number of sources increases. To address this issue, this paper proposes an improved DOA estimation method based on a support set of the sparse vector with an Atomic Norm Minimization (ANM) algorithm. The method constructs a support set of the sparse vector to enhance the sparse support degree. Then, the ANM algorithm is performed on the support set of the sparse vector to obtain DOA estimation results. Simulation results show that the proposed method improves the performance of DOA estimation compared to the classic ANM algorithm, particularly when the sparsity approaches or exceeds the number of array elements.
Climate in Earth history

Complex atmosphere-ocean-land interactions govern the climate system and its variations. During the course of Earth history, nature has performed a large number of experiments involving climatic change; the geologic record contains much information regarding these experiments. This information should result in an increased understanding of the climate system, including climatic stability and factors that perturb climate. In addition, the paleoclimatic record has been demonstrated to be useful in interpreting the origin of important resources-petroleum, natural gas, coal, phosphate deposits, and many others.
Physical Mechanisms Driving Enhanced Carbon Sequestration by the Biological Pump Under Climate Warming

As ocean Carbon Dioxide Removal techniques are being considered, it is critical that they be evaluated against our scientific understanding of the global biological carbon pump. In a recent paper Nowicki et al. (2022, https://doi.org/10.1029/2021GB007083) provide an innovative and comprehensive breakdown of the different mechanistic pathways of carbon sequestration through the present‐day biological pump but then speculate that “These results suggest that ocean carbon storage will weaken as the oceans stratify and the subtropical gyres expand due to anthropogenic climate change. ” Essentially, the authors combine their steady state result that oligotrophic subtropical gyres have lower residence times than other areas with the climate change result of these areas increasing under climate warming and extrapolate—assuming “all else is equal”—that the overall ocean will suffer a reduction in carbon sequestration efficiency. Expressing global changes in carbon sequestered by the ocean's biological pump as the summation of local changes in the sequestered carbon, timescale of return to the surface, and biogeographical area, I discuss how all three terms are tightly coupled, and summarize decades of climate change modeling consistently indicating that the global scale physical sequestration response is an increase ‐ in opposition of what one would infer from changes in subtropical area alone.
Crack Propagation and Fragmentation Characteristics of Single-Flawed Sandstone Samples under Different Loading Conditions

Red sandstone specimens with preexisting single flaw were taken as the research object in the static and dynamic loading tests. A hydraulic press was used for the uniaxial compression experiment, and SHPB was used for the impact test. The corresponding static and dynamic stress-strain curves were obtained. The crack propagation of rock samples under different loading conditions was obtained using the camera system. The crack propagation, compressive strength, and energy characteristics of samples under quasi-static and dynamic impact loading were analyzed. The findings show that the crack initiation, development, and final fracture mode of the samples are closely related to the inclination angle of preexisting flaw and strain rate. Compared with samples under static loading, tensile and shear mixed cracks, layer separation cracks, and more far-field cracks appeared in the samples under dynamic loading. With the increase of the peak of incident wave during the SHPB test, the samples with preexisting flaw change from tensile crack to X-shaped shear failure in the range of medium strain rate. Under different loading conditions, the compressive strength of samples with 45° crack is the lowest. The energy dissipation density and energy dissipating rate of the single-flawed specimens feature a rising trend with the increasing peak of incident wave, and the influence of the inclination angle of preexisting flaw on the energy dissipation is significant for a given peak of incident wave. The strength, energy dissipation, and fractal dimension of the specimens are positively correlated with each other under different strength impact loading. As the peak of incident wave increases, the inclination angle of preexisting flaw has more significant influence on the interrelation of these three parameters.
Tryptophan Substitution in CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) Introduces δ-Opioid Receptor Antagonism, Preventing Antinociceptive Tolerance and Stress-Induced Reinstatement of Extinguished Cocaine-Conditioned Place Preference

The macrocyclic tetrapeptide CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) and its D-Trp isomer exhibit kappa opioid receptor (KOR) antagonism which prevents stress-induced reinstatement of extinguished cocaine-conditioned place preference. Here, we evaluated the effects of substitution of Trp and D-Trp on the peptides’ opioid activity, antinociceptive tolerance, and the ability to prevent relapse to extinguished drug-CPP. Six analogs were synthesized using a combination of solid-phase peptide synthesis and cyclization in solution. The analogs were evaluated in vitro for opioid receptor affinity in radioligand competition binding assays, efficacy in the [35S]GTPγS assay, metabolic stability in mouse liver microsomes, and for opioid activity and selectivity in vivo in the mouse 55 °C warm-water tail-withdrawal assay. Potential liabilities of locomotor impairment, respiratory depression, acute tolerance, and conditioned place preference (CPP) were also assessed in vivo, and the ameliorating effect of analogs on the reinstatement of extinguished cocaine-place preference was assessed. Substitutions of other D-amino acids for D-Trp did not affect (or in one case increased) KOR affinity, while two of the three substitutions of an L-amino acid for Trp decreased KOR affinity. In contrast, all but one substitution increased mu opioid receptor (MOR) affinity in vitro. The metabolic stabilities of the analogs were similar to those of their respective parent peptides, with analogs containing a D-amino acid being much more rapidly metabolized than those containing an L-amino acid in this position. In vivo, CJ-15,208 analogs demonstrated antinociception, although potencies varied over an 80-fold range and the mediating opioid receptors differed by substitution. KOR antagonism was lost for all but the D-benzothienylalanine analog, and the 2′-naphthylalanine analog instead demonstrated significant delta opioid receptor (DOR) antagonism. Introduction of DOR antagonism coincided with reduced acute opioid antinociceptive tolerance and prevented stress-induced reinstatement of extinguished cocaine-CPP.
Design Model and Synchronous Controllers for a Dual 3-DOF Manipulator based on CAN Network

This paper mentions two synchronous control algorithms for a dual 3-degree-of-freedom (3-DOF) manipulator robot based on the CAN BUS network, including the master-slave approach (MSA) and cross-coupling control (CCC) algorithms. In the MSA synchronization algorithm, the set trajectory of the master robot is the desired set trajectory, and the set trajectory of the slave robot is the output position of the master robot. In the CCC synchronization algorithm, the set trajectories of the dual arm manipulators ensure stability and synchronize their movements while maintaining the desired trajectory. In this paper, the robot model is designed using SolidWorks software. Then the data is transferred to Simscape software combined with MATLAB Simulink to simulate and evaluate the two synchronous control methods mentioned. An experimental model of a dual 3-DOF manipulator is being constructed to evaluate the practical effectiveness of these two methods, which use the CAN BUS protocol for communication between them. The study utilizes 2-level distributed control based on the CAN BUS protocol. At level 1, this protocol is applied to communicate with the microcontroller, which controls the joints of the two robotic arms. At level 2, this protocol is applied to interface with the microcontroller, which controls the dual 3-DOF manipulator. Finally, the simulation results and experimental models based on the CAN-BUS protocol are used to evaluate the synchronization effect of the two proposed methods.
Resistance Profiles and Virulence Determinants in Biofilm-Forming Enterococcus faecium Isolated from Raw Seafood in Bangladesh

Pathogenic, antibiotic-resistant, and biofilm-forming bacteria can be transferred to humans through the consumption of contaminated seafood. The present study was carried out to determine antibiotic resistance profiles and virulence determinants in biofilm-forming Enterococcus faecium isolated from seafood in Bangladesh. A total of 150 seafood samples, including shrimp (n = 50), crabs (n = 25), and marine fish (n = 75), were screened using cultural, staining, biochemical, polymerase chain reaction (PCR), Congo red (CR), and disk diffusion (DD) assays. In PCR, E. faecium was detected in 27.3% (41/150; CI95% 20.8; 34.9) of samples, where marine fish (34.7%, CI95% 24.9; 45.9) had the highest prevalence (p < 0.05) compared to crabs (32%, CI95% 17.2; 51.6) and shrimp (14%, CI95% 7.0; 26.1). Thirty-two (78.1%, CI95% 63.3; 88.0) of the E. faecium isolates were determined to be biofilm formers in the CR test, where 43.9% (18/41, CI95% 29.9; 59.0) and 34.2% (14/41, CI95% 21.6; 49.5) of the isolates were strong and intermediate biofilm formers, respectively. In PCR, virulence genes, i.e., pil (100%), ace (92.7%), agg (68.3%), fsrA (65.9%), gelE (63.4%), sprE (53.7%), fsrB (51.2%), and fsrC (43.9%), were detected in E. faecium isolates. All the E. faecium isolates were phenotypically resistant to ≥3 antimicrobial categories and ≥3 antibiotics, including WHO-classified reserve antibiotics linezolid (70.7%) and fosfomycin (19.5%). Moreover, the multiple antibiotic resistance index ranged up to 0.8, showing resistance to ten antibiotics and eight antibiotic classes. In this study, the prevalence of virulence genes and antibiotic resistance was significantly greater (p < 0.05) in strong biofilm-forming E. faecium strains as compared to strains with intermediate and non-biofilm-forming abilities. As far as we know, this study, for the first time in Bangladesh, determined antibiotic resistance and detected virulence genes in biofilm-forming E. faecium isolated from seafood samples. The data from this study could play a significant role in evaluating potential health hazards linked to the ingestion of uncooked or minimally processed seafood.
The influence of exposure to various concentrations of five antimicrobial agents on intracellular cytotoxin B production in Clostridioides difficile

Background: Clostridioides difficile is an important cause of healthcare-associated diarrhea. Several anti- microbial agents are known to promote C. difficile infection (CDI). The impact of various concentrations of ampicillin (AMP), cefotaxime (CTX), clindamycin (CC), metronidazole (MTZ) and vancomycin (VAN) on intra-cellular cytotoxin B production was investigated in this study. Methodology: Six clinical strains of C. difficile were grown at minimum inhibitory concentration (MIC) and sub-MIC concentrations of these antibiotics. Inoculum standardization was performed by Miles and Misra method. Intracellular toxin B production was detected using Vero cell cytotoxicity assay in sonicated cultures on days 1, 2, 3, 4, 5 and 7 days of incubation. Results: There was a heterogeneous relationship between antibiotic exposure and the intra-cellular toxin production by the toxigenic strains. Clinical strains of C. difficile when exposed to MIC and sub-inhibitory concentrations of certain antibiotics produced high cytotoxin levels. All toxigenic isolates produced increased levels of cell-bound cytotoxin after exposure to antibiotics but there was no consistent pattern and the response to different doses varied considerably. Metronidazole was the most potent inducer of cell-bound cytotoxin followed by cefotaxime and clindamycin. Vancomycin induced the least amount of cytotoxin activity. Conclusion: The effects of sub-inhibitory concentration of antibiotic that predispose to C. difficile infection may partially suppress the normal gut flora, allowing colonization and growth of C. difficile, and may affect the level of toxin produced.
Efficacy of Laser Therapy on Paralysis and Disability in Patients with Facial Palsy: A Systematic Review of Randomized Controlled Trials

(1) Background: Facial palsy is a common health issue which leads to sequelae and disability. This systematic review aimed to assess the efficacy of laser therapy for the treatment of facial palsy. (2) Methods: Only randomized controlled trials comparing the effectiveness of laser therapy to non-laser intervention, no intervention, or placebo were searched for. Relevant studies were searched in seven electronic databases. Studies that examined the use of laser modalities for facial palsy management, with or without acupuncture, were also included. Two authors independently read and scored the methodological quality of the selected texts, and any disagreement was resolved by discussion or by intervention from the third author. (3) Results and conclusions: With five full-text articles, a methodological quality for each included study was assessed (kappa coefficient = 0.75). The laser therapy group in the mean difference measuring FDI showed an effect size of 8.15 compared to the control group; while measuring the paralysis score, an advantage was disclosed with an effect size of 0.22 compared to the control group.