Miracle-dz/UniFAR-FTUs huggingface dataset:
877 IL-1 Plays an Important Role in Lipid Metabolism by Regulating Insulin Levels under Physiological

Japan Abstract IL-1 is a proinflammatory cytokine that plays important roles in inflammation. However, the role of this cytokine under physiological conditions is not known completely. In this paper, we analyzed the role of IL-1 in maintaining body weight because IL-1 receptor antagonist–deficient (IL-1Ra (cid:2) / (cid:2) ) mice, in which excess IL-1 signaling may be induced, show a lean phenotype. Body fat accumulation was impaired in IL-1Ra (cid:2) / (cid:2) mice, but feeding behavior, expression of hypothalamic factors involved in feeding control, energy expenditure, and heat production were normal. When IL-1Ra (cid:2) / (cid:2) mice were treated with monosodium glutamate (MSG), which causes obesity in wild-type mice by ablating cells in the hypothalamic arcuate nucleus, they were resistant to obesity, indicating that excess IL-1 signaling antagonizes the effect of MSG-sensitive neuron deficiency. IL-1Ra (cid:2) / (cid:2) mice showed decreased weight gain when they were fed the same amount of food as wild-type mice, and lipid accumulation remained impaired even when they were fed a high-fat diet. Interestingly, serum insulin levels and lipase activity were low in IL-1Ra (cid:2) / (cid:2) mice, and the insulin levels were low in contrast to wild-type mice after MSG treatment. These observations suggest that IL-1 plays an important role in lipid metabolism by regulating insulin levels and lipase activity under physiological
Managing Intraocular Pressure: Innovation in Glaucoma Management Managing Intraocular Pressure: Innovation in Glaucoma Management

Primary open-angle glaucoma is a progressive ocular neuropathy that if left untreated may lead to blindness. The main risk factor for developing glaucoma is increased intraocular pressure. Intraocular pressure is regulated by the balance of aqueous humour synthesis and secretion into the eye and outflow from the eye; therefore, most therapies for glaucoma seek lowering intraocular pressure to avoid disease progression. There are several types of drugs in the market for the treatment of glaucoma, but there are still unmet needs to be overcome; therefore, significant effort has been put in the last few years to develop new medicines with innovative mechanisms of action as well as devices to improve quality of life in glaucoma patients. The present review offers a thorough revision of the latest advances in the glaucoma therapy field, focusing on innovative approaches, new targets and new mechanisms of action.
A Proportional Pattern Recognition Control Scheme for Wearable A-mode Ultrasound Sensing

It is evident that the prevailing solution, myoelectric pattern recognition for prosthetic manipulation, constrains gesture-based interaction because of the lack of proportional control information such as exerted force. This paper reports an attempt, named simultaneous gesture recognition and muscle contraction force estimation, to realize proportional pattern recognition (PPR) control taking advantage of arm muscle deformation via wearable ultrasound sensing. We experiment with eight types of predefined hand motions, with a range of 0–60% maximum voluntary contraction (MVC) using a wearable multichannel A-mode ultrasound system. The experiment result demonstrates that above 93.7% of gestures are correctly recognized during dynamic muscle contraction forces (0–60% MVC), albeit only training at a slight force level (<6% MVC). Besides, the adopted nonparametric Gaussian process regression estimates the muscle contraction forces accurately and synchronously, with average coefficient of determination, ${\bf R}^{\bf {2}}$, and normalized root-mean-square error ($nRMSE$) of 0.927 and 0.102, respectively. These research outcomes demonstrate the feasibility of ultrasound-based PPR control, paving the way for musculature-driven applications such as finer prosthetic control, remote manipulation, and rehabilitation treatment.
Medicinal plants used by a Traditional Ayurvedic Practitioner at Village in Narsingdi District, Bangladesh

Ethnobotany is the local traditional knowledge of utilizing indigenous plants, such as for food, medicine and tools, that local people have been practicing for a long time. The utilization of plant species found in nature varies in each region. Local folk wisdom on botanical uses has been applied in nature to the advantage of ethnic groups for a long time. Bangladesh has tremendous wealth of medicinal plants. Some plants were also used for the treatment of cancer, hypertension, nerve disorders, helmenthiasis, urinary tract infections, tuberculosis, leucorrhea, edema and chicken pox. Folk medicine forms the primary tier of health-care practices in Bangladesh. Narsingdi is one of early human settlements in Bangladesh. Thus we attempted to document the medicinal plant use of Monohardi area with a view to preserve the ethnobotanical knowledge and in order to protect the biodiversity of this area. The objective of this study was to document the medicinal uses of plants by a folk medicinal practitioner (Kaviraj) at Monohardi Upazila in Narsingdi district, Bangladesh. A total of 50 informants between the age group 20–86 years were interviewed with a questionnaire. The Kaviraj used 10 plants distributed into 7 families in his formulations. The study suggests that the medicinal plants used by the Kaviraj of Narsingdi district have good probability of new drug discoveries.
Mothers’ views of their preschool child’s screen-viewing behaviour: study.

Background: Research on screen-viewing in preschool children has predominantly focused on television viewing. The rapid development of mobile devices (e.g. tablets, smart phones and e-readers) and the increase in their use by preschool children means there is a need to understand how and why these devices are used by this age group. The aim of this study was to explore mothers ’ views of their preschool children ’ s screen viewing behaviour (including mobile devices) and investigate how preschool children use different screen-viewing devices. Methods: One-to-one, semi-structured interviews with mothers of preschool children (aged between 2 and 4 years old). Mothers were recruited through preschools, nurseries, and mother and toddler groups located within four areas of varying socio-economic status within Bristol, UK. Data were analysed thematically using a framework approach. Results: Twenty-six mothers were interviewed. Mobile devices were regularly used as a form of screen-viewing for most children but were used on an ad hoc basis rather than being a habitual activity. The reasons and influences of mobile device use described by mothers were similar to that of television viewing. However, the portability of mobile devices meant that they were often used outside of the home as a distraction tool. Their multi-functionality meant that they could be used as a portable television, or for purposeful learning through educational games and applications. Some mothers showed concerns over mobile device use by their child, whilst others felt it was an important and useful educational tool. Although the majority of mothers felt they needed to set rules and restrictions for mobile device use, many mothers felt that they are also a necessary and unavoidable part of life. Conclusions: Mothers in this study suggested that mobile device use by preschool children is common. More research is needed to determine the impact of mobile device use in preschool children, how much time preschool children spend using mobile devices and which activities their use may be replacing.
Geometric analysis in several complex variables

In this thesis, we answer several questions in the function theory of several complex variables which possess local geometric features but which need global non-linear analysis method for the solutions. The first result is to establish a very general algebraic mapping theorem and a reflection principle in any codimensional case. The algebraic theorem can be viewed as the real version of the celebrated Chow theorem. The second main concern is the interaction between invariant metrics of bounded domains and the holomorphic objects defined there. One of the main results in this regard is to give a precise description of the classical Denjoy-Wolff iteration theory on any strongly pseudoconvex domains with trivial topology. The approach to this problem is based on a very careful investigation on the boundary behavior of the Kobayashi extremal mappings; this also has several other applications. The last part of the thesis is devoted to the study of the structure of the local hull of holomorphy of a real surface in complex 2-dimensional space. The smooth and real analytic regularity results are obtained by solving certain non-linear equations.
Exact Green's Function for the Bethe Lattice in the Hopping Model

We calculated the exact self energy and the exact Green's function for the Bethe lattice in the hopping model using the Dyson's equation and from the fourth order of perturbation theory. The self energy is found from processes where an electron hops to its neighbors and includes terms where the particle hops twice to a next nearest neighbor (NNN) and then hops back. carried out by counting all non-self intersecting paths, leading to an implicit equation for the local Green function. By integrating out branches of the Bethe lattice, the same equation is obtained from a path integral approach for the partition function. In this study, the electron Green's function will be used to calculate the exact Green's function and self energy for the Bethe lattice in the hopping model. Though it is not one of the goals of our study here, it is pertinent to point out that the self energy can be used to obtain the vertex function which contains all the information on the kinetic and interaction behaviour of the particles in the system. Interestingly the vertex function can be decoupled into the charge vertex function and spin vertex function, thereby enabling the studying of either non-spin ordering systems or spin ordering system independently.
Jul 16, 2021 Multiple-Power-Sample Based P&O MPPT for Fast-Changing Irradiance Conditions for

—This article proposes an improved maximum power point tracking (MPPT) method that features a simple design, and improved efﬁciency in fast-changing irradiance conditions. The method uses three consecutive measurements and compares the power difference between each two consecutive samples, further- more the voltage variation between the last two successive samples is observed. According to the obtained result of these compar- isons, the algorithm applies the suitable action either increasing or decreasing the voltage. This simple concept allows easy imple- mentation and reduces the implementation cost and calculation
Bisophosphonates in the treatment of osteoporosis in women with breast cancer

Osteoporosis is the most common skeletal disorder. It is characterized by a decrease in bone density, which results in a greater likelihood of hip, vertebral and long bone fractures. Women who are undergoing hormonal treatment for hormone-related breast cancer are particularly at risk for osteoporosis. Among women diagnosed with premenopausal breast
Nanocrystalline Cellulose Isolation from Pulverized Kenaf Core using Hydrothermal Treatment with Low Concentration of Oxalic Acid

Isolation of nanocrystalline celluloses (NCC) from pulverized kenaf core (PKC) particles using hydrothermal treatment with low concentration of oxalic acid hydrolysis was investigated in this study. Prior to hydrolysis treatment, PKC particles were pretreated using alkali (NaOH) and bleaching treatments to eliminate lignin and hemicellulose. Zeta potential and particles size analysis showed that the zeta potential value and the average size of NCC obtained is -31.6 mV and 182.55 nm respectively. The median diameter, d 50 for the NCC suspension is 316.72 nm. A rough surface of flake shape agglomerated NCC particles was shown in SEM image. Fourier transform infrared (FTIR) spectroscopy showed the removal of lignin and hemicellulose after alkali treatment and bleaching process since there is no peak at wavelength number of 1740 and 1590 cm -1 . X-ray diffraction (XRD) analysis revealed that the crystallinity increased from 59.72% to 64.29%.
Enhanced Electrocatalytic Activity of Stainless Steel Substrate by Nickel Sulﬁdes for E ﬃ cient Hydrogen Evolution

: Water splitting is one of the e ﬃ cient ways to produce hydrogen with zero carbon dioxide emission. Thus far, Pt has been regarded as a highly reactive catalyst for the hydrogen evolution reaction (HER); however, the high cost and rarity of Pt signiﬁcantly hinder its commercial use. Herein, we successfully developed an HER catalyst composed of NiS x (x = 1 or 2) on stainless steel (NiS x / SUS) using electrodeposition and sulfurization techniques. Notably, the electrochemical active surface area(ECSA) of NiS x / SUS was improved more than two orders of magnitude, resulting in a considerable improvement in the electrochemical charge transfer and HER activity in comparison with stainless steel (SUS). The long-term HER examination by linear scan voltammetry (LSV) conﬁrmed that NiS x / SUS was stable up to 2000 cycles.
Consistent and protected End-to-End Data Aggregation Using Secret distribution in WSNs

- Data aggregation in WSNs (Wireless sensor Networks) can effectively reduce communication overheads and therefore the energy consumption of detector nodes. A WSN must be not solely energy economical, however conjointly secure. Varied attacks could build data aggregation unsecure. We investigate the reliable and secure end to-end data aggregation downside considering selective forwarding attacks and modification attacks in homogenous cluster-based WSNs, and propose two data aggregation approaches. Our approaches, namely, Sign-Share and Sham-Share, use secret sharing and signatures to permit aggregators to combination the data while not understanding the contents of messages and therefore the base station to verify the collective data and retrieve the raw data from the collective data.
Evolutionary Algorithm Based Extreme Learning Machine for Retrieval of Images

: In the present days, the importance of digital media or images has been improved. All the fields are utilizing these services at their maximum levels. It is because of easy acquisition, easy transmission, easy saving, easy retrieving, easy error correcting, etc. The cost of the storage devices also has been reasonable. Different storage or data servers are maintained to store these digital images. The storage capacity basically depends on image type, number of pixels of the image, number of grey levels of the image, number of dimensions of the image, number of features available in the images, etc. This paper presents an adaptive methodology for medical image retrieval.
Substandard and Falsiﬁed Medicines in Myanmar

: Background: substandard and falsiﬁed medicines (SFMs) are a threat to public health. The availability of SFMs in Myanmar was reported by the World Health Organization (WHO) in 1999, but there have been few systematic surveys on falsiﬁed medicines in Myanmar since then. The aim of this study is to examine the extent of SFMs for sale in Myanmar. Methods: target medicines were tablets of candesartan, metformin, and pioglitazone, and infusions of ciproﬂoxacin and levoﬂoxacin. Samples were collected from hospitals, pharmacies, and wholesalers located in the Mandalay region in 2015. We carried out observation testing, authenticity investigation, and quality testing to search for SFMs, and analyzed the relationship between SFMs and the price and store type. Results: There were no falsiﬁed medicines found in the authenticity check, though there remained a problem due to low response rates from manufacturers and regulatory authorities. In the quality test, some tablets of metformin and pioglitazone made in India failed the dissolution test. Conclusions: although no serious problems were found, some substandard medicines were detected. Regular surveys to monitor SFMs are therefore recommended, together with further regulatory guidance to improve conditions in all medicine manufacturers, distributors, and pharmacies.
Kissing Balloon Inﬂation in Percutaneous Coronary Interventions

Bifurcation lesions are the most frequently approached complex coronary lesions in everyday interventional practice. Bifurcations complexity relies essentially on their very speciﬁc anatomy that is imperfectly handled by current coronary devices and, despite dedicated techniques and drug-eluting stents, percutaneous coronary interventions directed toward the treatment of bifurcations are technically demanding and require proper execution. Kissing balloon (KB) inﬂation was the ﬁrst speciﬁc bifurcation technique to have been developed for percutaneous bifurcation interventions and continues to currently play an important role. Indeed, KB has been proposed to optimize stent apposition, improve side branch access while correcting stent deformation or distortion. Over the years, the KB technique has been deeply investigated by many different methods, from bench testing and computer simulations to in vivo intravascular imaging and clinical studies, producing a large amount of data pointing out the beneﬁts and limitations of the technique. We sought to provide here a comprehensive overview of all those aspects. (J Am Coll Cardiol Intv 2012;5:803–11) © 2012 by the American College of Cardiology Foundation
MAXIMAL INFORMATION FROM LOCAL ALIGNMENTS

Accurate identification of homologs, through sequence similarity searching programs like BLAST, is central to converting genome sequence data to biological knowledge. BLAST, FASTA, and other widely used search programs use local alignments to identify homologous sequences based on shared domains, but the boundaries of local alignments reflect both the signal from homology and the intrinsic properties of the alignment scoring matrix. Reliable identification of homologous domains requires sensitive alignment methods, accurate statistical estimates, and accurate alignment boundaries. Matrices that produce sensitive searches can also produce inaccurate alignments for more closely related homologs. Past improvements in search strategies focussed on search sensitivity and statistical accuracy, but largely ignored boundary accuracy. Homologous overextension, a boundary error that occurs when two homologous domains are aligned, but the alignment extends beyond the ends of the domains, can propagate inaccurate functional predictions and contaminate models used in more sensitive similarity searches. In this thesis, I discuss the theoretical and empirical basis for homologous overextension. In Chapter 1, I outline the properties of local similarity scoring matrices that can produce alignment overextension. In Chapter 2, I show that overextension occurs in 8% of alignments in comprehensive searches, increasing to 10% for the 100 most similar alignments. About half of this overextension occurs because of a mismatch between the alignment identity of the homologous domain and the target identity of the scoring matrix used in the initial alignment and more than 85% of this high-identity alignment overextension can be corrected by shifting to the appropriate scoring matrix. In Chapter 3, I consider alignment over extension in other contexts and summarize additional strategies for identifying over extension. Alignment accuracy is central to effectively exploiting our growing knowledge about structure-function relationships, active sites, and variant phenotypes. Future characterizations of alignment methods should examine both internal and alignment boundary accuracy.
Effective Navigation of Query Results for Knowledge on Data Engineering

---The MEDLINE database, on which the PubMed search engine operates, contains over 18 million citations, and the database is currently growing at the rate of 500,000 new citations each year. Other biological sources, such as Entrez Gene and OMIM, witness similar growth. As claimed in previous work, the ability to rapidly survey this literature constitutes a necessary step toward both the design and the interpretation of any large scale experiment. Biologists, chemists, medical and health scientists are used to searching their domain literature – such as PubMed– using a keyword search interface. Currently, in an exploratory scenario where the user tries to find citations relevant to her line of research and hence not known a priori, she submits an initially broad keyword-based query that typically returns a large number of results. Subsequently, the user iteratively refines the query, if she has an idea of how to, by adding more keywords, and re-submits it, until a relatively small number of results are returned. This refinement process is problematic because after a number of iterations the user is not aware if she has over-specified the query, in which case relevant citations might be excluded from the final query result.
AIS Electronic Library (AISeL) Habitual IS Use and Continuance

Information systems (IS) use literature and research has been extensive, and has been able to explain a significant amount of the variation in IS acceptance and adoption. The majority of this research has focused on technologies we intentionally use in a work type setting. This current proposed study extends this literature by focusing on automatic use that is non-work related. Understanding the factors that influence the continued use of an IS after initial adoption is important because continued use of a system is an appropriate measure for determining whether or not the IS is actually successful. Habitual IS use is presented and explored to contribute to the understanding of IS continuance. An habitual IS continuance (HIC) model is conceptually developed and proposed. The development of an HIC model allows system success to be measured in voluntary use information systems.
Identiﬁcation of Multivesicular Bodies as Prevacuolar Compartments in Nicotiana tabacum BY-2 Cells W

Little is known about the dynamics and molecular components of plant prevacuolar compartments (PVCs). We have demonstrated recently that vacuolar sorting receptor (VSR) proteins are concentrated on PVCs. In this study, we generated transgenic Nicotiana tabacum (tobacco) BY-2 cell lines expressing two yellow ﬂuorescent protein (YFP)-fusion reporters that mark PVC and Golgi organelles. Both transgenic cell lines exhibited typical punctate YFP signals corresponding to distinct PVC and Golgi organelles because the PVC reporter colocalized with VSR proteins, whereas the Golgi marker colocalized with mannosidase I in confocal immunoﬂuorescence. Brefeldin A induced the YFP-labeled Golgi stacks but not the YFP-marked PVCs to form typical enlarged structures. By contrast, wortmannin caused YFP-labeled PVCs but not YFP-labeled Golgi stacks to vacuolate. VSR antibodies labeled multivesicular bodies (MVBs) on thin sections prepared from high-pressure frozen/freeze substituted samples, and the enlarged PVCs also were indentiﬁed as MVBs. MVBs were further puriﬁed from BY-2 cells and found to contain VSR proteins via immunogold negative staining. Similar to YFP-labeled Golgi stacks, YFP-labeled PVCs are mobile organelles in BY-2 cells. Thus, we have unequivocally identiﬁed MVBs as PVCs in N. tabacum cells. Uptake studies with the styryl dye FM4-64 strongly indicate that PVCs also lie on the endocytic pathway of BY-2 cells.