Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Ga-68 DOTANOC Positron Emission Tomography/ Computed Tomography Scan in Clinical Management of Patients with Neuroendocrine Tumors and its Correlation with Conventional Imaging- Experience in a Tertiary Care Center in India

Purpose of Study: Aim of the study was to evaluate the role of 68Gallium-DOTANOC positron emission tomography/computed tomography (68Ga-DOTANOC PET/CT), a pan somatostatin receptor (SSTR) analog in the clinical management of patients with neuroendocrine tumors (NETs) and its correlation with conventional imaging. Materials and Methods: We retrospectively evaluated 69 patients of known/suspected NETs who underwent 68Ga-DOTANOC PET/CT scan for tumor localization (n = 15), stage modification (primary staging, n = 26 and restaging, n = 25) and therapy monitoring (n = 3). We also compared PET scan with conventional imaging as reference standard and evaluated the impact of PET/CT in the clinical management of patients. Results: The concordant findings on 68Ga-DOTANOC PET/CT and conventional imaging seen in 33 and discordant in 36 patients. Among discordant group, disease was upstaged in 32 patients; down staged in 3 patients; no stage change in one patient. PET/CT localized primary tumor in 4 patients. Among patients with raised tumor markers (39/69), PET was positive in 29 and negative in 10 patients. Patients were followed for mean duration of 27 months to assess management. We found strong agreement between positive PET and raised tumor markers (Kappa value = 0.8). Sensitivity and specificity of PET/CT for primary tumor localization, stage modification, and therapy monitoring was >90% (P < 0.05). Conclusions: Study shows that DOTANOC, a broad spectrum SSTRs binding peptide labeled with Ga-68 in PET/CT scan is an excellent modality in the management of NETs patients.
A Survey on Secure PIN Authentication for ATM Transactions

Automated teller machine is very popular and most efficient ways for transaction of money. It perform financial transactions mostly cash withdrawal. It reduces the work load of banks as it is fully automated. Currently, Personal Identification Number(PIN) is used for security in ATMs and authentication is provided to the Users by entering the personal identification number (PIN). These PIN numbers can be hacked easily through specific fraudulent activities and it can be observed by human or device attackers. This paper describes aboutattacks on pin entry and secureATM Transactionsmethods used to reducephysical and electronic theft in ATMs.
FACE RECOGNITION USING LINEAR DISCRIMINANT ANALYSIS

: Linear Discriminant Analysis (LDA) has been successfully applied to face recognition which is based on a linear projection from the image space to a low dimensional space by maximizing the between class scatter and minimizing the within-class scatter. LDA allows objective evaluation of the significance of visual information in different features of the face for identifying the human face. The LDA also provides us with a small set of features that carry the most relevant information for classification purposes. LDA method overcomes the limitation of Principle Component Analysis method by applying the linear discriminant criterion. This criterion tries to maximize the ratio of determinant of the between-class scatter matrix of the projected samples to the determinant of the within-class scatter matrix of the projected samples. Linear discriminant groups the images of the same class and separate images of different classes. Here to identify an input test image, the projected test image is compared to each projected training, and the test image is identified as the closest training image. The experiments in this paper we present to use LDA for face recognition. The experiments in this paper are performed with the ORL face database. The experimental results show that the correct recognition rate of this method is higher than that of previous techniques.
TELAAH PUSTAKA ANALISIS FAKTOR YANG MEMPENGARUHI KEPUTUSAN NASABAH DALAM MEMILIH TRANSAKSI MENGGUNAKAN MOBILE BANKING (Studi Kasus PT.Bank Muamalat Tbk. Kota Malang)

Perilaku konsumen adalah setiap pemakai atau pengguna barang atau jasa baik untuk kepentingan diri sendiri dan atau kepentingan orang lain. Namun secara sederhana dapat diartikan sebagai pengguna barang dan atau jasa. Konsumen dalam penelitian ini adalah nasabah PT. Bank Muamalat Tbk. Kota Malang dalam keputusan memilih jenis transaksi yaitu antara sistem transaksi menggunakan Teller, ATM, dan Mobile Banking. Perilaku konsumen memiliki dua faktor yaitu yang pertama adalah faktor internal meliputi kognisi konsumen dan afeksi konsumen, kemudian faktor yang kedua yaitu faktor eksternal meliputi lingkungan sosial mikro dan lingkungan sosial makro. Dari faktor-faktor tersebut maka adanya keputusan memilih sebuah transaksi yang meliputi mengenali kebutuhan, pencarian informasi, evaluasi alternatif, keputusan membeli, dan tingkah laku pasca pembelian. Penelitian ini memiliki variabel-variabel yang diduga memiliki pengaruh terhadap keputusan memilih jenis transaksi menggunakan mobile banking, Variabel tersebut diantaranya adalah usia, pendidikan, kemudahan penggunaan, daya guna, kenyamanan, dan kepercayaan. Kata Kunci: Perilaku Nasabah, Pemilihan Transaksi, Mobile Baking
Improved hydrological projections and reservoir management in the Upper Indus Basin under the changing climate

The availability of water resources plays an important role for the economy of a country. The nexus of energy‐food‐water are interlinked and of particular importance in the uncertain environment of developing countries. In Pakistan, agriculture contributes 25% to the gross domestic product. The Indus River contributes 44% of the available water to irrigation of crops and the ecosystem, and currently produces 5,112 MW electricity, with the potential to produce 38,602 MW electricity. This makes it important to investigate the status of water availability in the Upper Indus Basin under existing emission scenarios. In this study, the future availability of water is projected for the Indus River under the A2, B2, RCP4.5 and RCP8.5 emission scenarios. A meta‐analysis has been conducted to present a combined picture by combining the results from the emission scenarios. Our meta‐analysis shows higher confidence in RCPs projections. The results show that suffcient water will be available in the Indus River that will meet the demands of water in future but there will be scarcity of water in some months under each scenario. However, by proper management and optimum utilisation of the available water, this scarcity can be resolved.
A SIMULATOR SICKNESS CASE STUDY ON THE NADS

A simulator fidelity study was performed on the NADS that compared drives with and without motion and scenarios with varying levels of visual fidelity. Simulator sickness levels were higher than average, resulting in above average drop-out rates. Though the goal of the study was not to study sim sickness, the factors in the study make it an interesting and informative case study. The occurrence of simulator sickness is complicated; but one generally accepted reason for sim sickness is cue mismatch between the vestibular and ocular systems. Also important are aspects of the visual system such as field-of-view. However, driver susceptibility is also an important factor that causes some people to become symptomatic very quickly, while others never present symptoms. We consider the presence of motion cues, the visual scene, the sickness scores, and the final disposition of the driver (dropped out or completed); and look at several driver performance dependent measures. The goal was to determine if and how the presence of sickness affects driver inputs and other measures of driver performance. This paper presents some interesting and significant findings.
Crypto dynamics during market downturns: Another dotcom boom-bust cycle?

The cryptocurrency ecosystem has experienced astounding growth in the last two years, with 400% price increases within a year, as well as the launch of thousands of new coins and tokens. These factors have led the public to compare the crypto phenomenon to the dotcom boom of the late 1990s, in which we saw some 2000 internet IPOs, and their representative index (the Nasdaq) also saw extraordinary gains over a short period. The Nasdaq’s meteoric rise was followed by a dramatic crash in the early 2000s, leading to a loss of nearly 80% from peak to trough. If the dotcom boom-bust cycle is indeed a precedent for crypto, the inevitable forecast would be an impending collapse in the value of cryptocurrencies. In this article, we drill below the surface similarities of the dotcom and crypto markets and examine the behavior of market participants during selloffs in both scenarios. We find that investor responses are markedly different, suggesting that forecasts of an impending sustained loss of value in the crypto space may be exaggerated. We conclude by providing tentative justification for the hypothesis that cryptocurrencies may in fact represent an entirely new asset class.
PREFERENCES, PERCEPTION OF READINESS AND SATISFACTION TOWARDS ONLINE DISTANCE LEARNING AMONG UNDERGRADUATES IN MALAYSIA DURING COVID-19 PANDEMIC

While there is abundance of studies regarding online distance learning (ODL) among university students, information regarding ODL among undergraduates in Malaysia is limited, more so during the Covid-19 pandemic. This was a cross-sectional online survey involving a total of 308 undergraduates from various universities in Malaysia aimed to evaluate undergraduates’ perception of readiness and satisfaction towards online distance learning, platform preferences, attitudes and motivations, barriers towards ODL and also factors contributing to these variables. Questionnaires that include Online Learning Readiness Scale (OLRS) and additional information regarding challenges faced by undergraduates and their satisfaction levels towards ODL were used in this survey. The results showed
Update on the Neisseria Macrophage Infectivity Potentiator-Like PPIase Protein

Neisseria pathogens express a Macrophage Infectivity Potentiator Protein (MIP), which belongs to the FK506 binding protein (FKBP) family of proteins that exhibit peptidyl-prolyl cis/trans isomerase (PPIase) activity. Neisseria MIP proteins are potential candidates for inclusion into vaccines for gonorrhoea caused by N. gonorrhoeae infection, and meningitis/sepsis caused by M. meningitidis infection. Neisseria MIP proteins are also potential targets for directed drug treatments, although this remains relatively unexplored. In this mini-review, we provide an update into the vaccine potential of Neisseria MIP and the few published drug targeting studies, and explore further the diversity of this protein amongst both pathogenic and commensal Neisseria spp.
Alpha-Asaronol Alleviates Dysmyelination by Enhancing Glutamate Transport Through the Activation of PPARγ-GLT-1 Signaling in Hypoxia-Ischemia Neonatal Rats

Preterm white matter injury (PWMI) is the most common form of brain damage in premature infants caused by hypoxia-ischemia (HI), inflammation, or excitotoxicity. It is characterized by oligodendrocyte precursor cell (OPC) differentiation disorder and dysmyelination. Our previous study confirmed that alpha-asarone (α-asaronol), a major compound isolated from the Chinese medicinal herb Acorus gramineus by our lab, could alleviate neuronal overexcitation and improve the cognitive function of aged rats. In the present study, we investigated the effect and mechanism of α-asaronol on myelination in a rat model of PWMI induced by HI. Notably, α-asaronol promoted OPC differentiation and myelination in the corpus callosum of PWMI rats. Meanwhile, the concentration of glutamate was significantly decreased, and the levels of PPARγ and glutamate transporter 1 (GLT-1) were increased by α-asaronol treatment. In vitro, it was also confirmed that α-asaronol increased GLT-1 expression and recruitment of the PPARγ coactivator PCG-1a in astrocytes under oxygen and glucose deprivation (OGD) conditions. The PPARγ inhibitor GW9662 significantly reversed the effect of α-asaronol on GLT-1 expression and PCG-1a recruitment. Interestingly, the conditioned medium from α-asaronol-treated astrocytes decreased the number of OPCs and increased the number of mature oligodendrocytes. These results suggest that α-asaronol can promote OPC differentiation and relieve dysmyelination by regulating glutamate levels via astrocyte PPARγ-GLT-1 signaling. Although whether α-asaronol binds to PPARγ directly or indirectly is not investigated here, this study still indicates that α-asaronol may be a promising small molecular drug for the treatment of myelin-related diseases.
Gender Specificity and Local Socioeconomic Influence on Association of GHR fl/d3 Polymorphism With Growth and Metabolism in Children and Adolescents

Objective Growth hormone receptor (GHR) mediates most GH biological actions. This study is aimed to evaluate whether GHR fl/d3 polymorphism contributes to the inter-individual variability of growth and metabolism in healthy children and adolescents. Methods A total of 4,730 students aged 6-16 years from Yixing and Suqian City in China were included in this cross-sectional study. Height and body mass index (BMI) were transformed into the form of z-score corresponding to age and gender. Logistic regression was used to evaluate the associations of GHR fl/d3 polymorphism with height, BMI, metabolic traits, and hypertension by estimating the odds ratios (ORs) and 95% confidence intervals (CIs). Results GHR d3 allele was inversely associated with overweight, total cholesterol (TC) and triglyceride (TG) levels (OR [95% CI] for overweight: 0.754 [0.593-0.959], P = 0.021; OR [95% CI] for TC: 0.744 [0.614-0.902], P = 0.003; OR [95% CI] for TG: 0.812 [0.654-0.998], P = 0.047). GHR d3 allele was associated with decreased odds of pre-hypertension in boys (OR [95% CI]: 0.791 [0.645-0.971], P = 0.025), but associated with increased odds of pre-hypertension and hypertension in girls (ORs [95% CIs]: 1.379 [1.106-1.719], P = 0.004; OR [95% CI]: 1.240 [1.013-1.519], P = 0.037). Interaction of GHR fl/d3 polymorphism with gender contributed to increased odds of pre-hypertension and hypertension (interactive ORs [95% CIs]: 1.735 [1.214-2.481], P = 0.003; OR [95% CI]: 1.509 [1.092-2.086], P = 0.013). Stratification analysis showed that the correlation tendencies of GHR fl/d3 polymorphism and BMI with age were different between two cities with discrepant economic development levels. Conclusion GHR fl/d3 polymorphism is associated with growth, metabolism, and hypertension in children and adolescents with the gender specificity, and the genetic effect of GHR fl/d3 may be modified by the local socioeconomic levels.
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells

In this study, we aimed to reveal the resistance mechanism of hepatocellular carcinoma (HCC) cells to sorafenib by exploring the effect of FNDC5 on sorafenib-induced ferroptosis in HCC cells. We compared the expression level of FNDC5 between sorafenib-resistant and sorafenib-sensitive HCC cell lines and the level of ferroptosis between the groups after treatment with sorafenib. We knocked down FNDC5 in drug-resistant cell lines and overexpressed it in sorafenib-sensitive HCC cell lines to further demonstrate the role of FNDC5 in sorafenib-induced ferroptosis. Using PI3K inhibitors, we revealed the specific mechanism by which FNDC5 functions. In addition, we verified our findings obtained in in vitro experiments using a subcutaneous tumorigenic nude mouse model. The findings revealed that FNDC5 inhibits sorafenib-induced ferroptosis in HCC cells. In addition, FNDC5 activated the PI3K/Akt pathway, which in turn promoted the nuclear translocation of Nrf2 and increased the intracellular antioxidant response, thereby conferring resistance to ferroptosis. Our study provides novel insights for improving the efficacy of sorafenib.
Arbuscular Mycorrhizal Fungi Contribute to Phosphorous Uptake and Allocation Strategies of Solidago canadensis in a Phosphorous-Deficient Environment

Arbuscular mycorrhizal fungi (AMF) can facilitate the uptake of limiting or inaccessible nutrients by plants. However, the importance of AMF for invasive plants under phosphorus (P) limitation is poorly well understood because of the presence of non-focal microorganisms, such as endophytes or rhizosphere bacteria. In this study, we investigated how an invasive clonal plant Solidago canadensis benefits from the AMF Glomus intraradices by using a completely sterile culturing system, which is composed of aseptic seedlings, a pure AMF strain, and a sterile growth environment. We found that the colonization rate, abundance, and spore production of AMF in the insoluble P treatment was more than twice as much as in the available P treatment. Plant above-ground growth was enhanced almost 50% by AMF in the insoluble P treatment. Importantly, AMF were able to facilitate P acquisition by the plant in insoluble P conditions, allowing plants to have lower investment into below-ground biomass and higher benefit/return for above-ground biomass. This study demonstrated the important contribution that AMF make to plants in phosphate-deficient environments eliminating interference from non-focal microorganisms. Our results also suggest that interaction with AMF could contribute to the invasiveness of clonal plant S. canadensis in a resource-deficient environment.
Alterations in Muscle Force Control With Aging: Is There a Modulatory Effect of Lifelong Physical Activity?

Recent technological developments have enabled significant advances in our understanding of the ability to voluntarily control muscle force output. The fluctuations inherent to muscle force output can be quantified according to both their magnitude and temporal structure (or “complexity”), with such quantification facilitating comparison of force control between distinct populations. In comparison to young adults, older adults exhibit an increase in the magnitude (i.e., decreased steadiness) and a decrease in the complexity (i.e., decreased adaptability) of force fluctuations, both of which are indicative of a loss of force control. There remain, however, key gaps in knowledge that limit our interpretation of this age-related loss of force control. One such gap relates to the effect of lifelong physical activity on force control. To date, research on aging and force control has largely been conducted on inactive or moderately active older adults. However, high levels of lifelong physical activity, such as that exhibited by Masters athletes, have been shown to have protective effects on the function and morphology of the neuromuscular system. Some of these effects (e.g., on impaired inhibitory transmission in the motor cortex and on motor unit discharge rates) have the potential to attenuate the age-related loss of force control, while others (e.g., greater motor unit remodeling capacity) have the potential to worsen it. We therefore propose that, in order to progress our knowledge of the effects of aging on force control, future studies must consider the potential modulatory effect of lifelong physical activity.
Controversial Flow Cytometry Monitoring of a Relapse Case of Pediatric T Cell Acute Lymphoblastic Leukemia: A Case Report

Acute lymphoblastic leukemia (ALL) is the most frequent childhood cancer, with 80–85% represented by B cell ALL and only 15% by T cell ALL. T Cell ALL (T-ALL) carries a more reserved prognosis compared to B Cell ALL (B-ALL) with regard to response to treatment, risk of relapse, and overall survival. Progress made in current monitoring protocols such as via flow cytometry immunophenotyping (FCM) and by PCR-based amplification of antigen-receptor genes led to improved management of patients with ALL and superior rates of survival. Nevertheless, challenges remain in some clinical cases. This manuscript describes a unique case of T-ALL and raises awareness of such clinical challenges. The article presents an overview of the flow cytometry immunophenotyping at diagnosis and during treatment of a pediatric patient with T-ALL from Fundeni Clinical Institute. In this case, in spite of various therapeutic measures such as first-line chemotherapy for high risk group, salvage chemotherapy (FLAG), conditioning regimen (FLU-BU-TT-ATG), and stem cell transplant, a chemoresistance clone continued to be present.
On Aerial Robots with Grasping and Perching Capabilities: A Comprehensive Review

Over the last decade, there has been an increased interest in developing aerial robotic platforms that exhibit grasping and perching capabilities not only within the research community but also in companies across different industry sectors. Aerial robots range from standard multicopter vehicles/drones, to autonomous helicopters, and fixed-wing or hybrid devices. Such devices rely on a range of different solutions for achieving grasping and perching. These solutions can be classified as: 1) simple gripper systems, 2) arm-gripper systems, 3) tethered gripping mechanisms, 4) reconfigurable robot frames, 5) adhesion solutions, and 6) embedment solutions. Grasping and perching are two crucial capabilities that allow aerial robots to interact with the environment and execute a plethora of complex tasks, facilitating new applications that range from autonomous package delivery and search and rescue to autonomous inspection of dangerous or remote environments. In this review paper, we present the state-of-the-art in aerial grasping and perching mechanisms and we provide a comprehensive comparison of their characteristics. Furthermore, we analyze these mechanisms by comparing the advantages and disadvantages of the proposed technologies and we summarize the significant achievements in these two research topics. Finally, we conclude the review by suggesting a series of potential future research directions that we believe that are promising.
Developing a Sustainable Cardiovascular Disease Research Strategy in Tanzania Through Training: Leveraging From the East African Centre of Excellence in Cardiovascular Sciences Project

Introduction Cardiovascular disease (CVD) contribute the largest mortality burden globally, with most of the deaths (80% of all deaths) occurring in low and middle-income countries (LMICs), including Tanzania. Despite the increasing burden, to date, CVD research output is still limited in Tanzania, as it is for many sub-Saharan Africa (SSA) countries. This trend hinders the establishment of locally informed CVD management and policy changes. Here, we aim to review the existing gaps while highlighting the available opportunities for a sustainable CVD research strategy in Tanzania. Methods A rapid review of available literature on CVD research in SSA was conducted, with emphasis on the contribution of Tanzania in the world literature of CVD. Through available literature, we identify strategic CVD research priorities in Tanzania and highlight challenges and opportunities for sustainable CVD research output. Findings Shortage of skilled researchers, inadequate research infrastructure, limited funding, and lack of organized research strategies at different levels (regional, country, and institutional) are among the existing key bottlenecks contributing to the low output of CVD research in Tanzania. There is generally strong global, regional and local political will to address the CVD epidemic. The establishment of the East African Centre of Excellence in Cardiovascular Sciences (EACoECVS) offers a unique opportunity for setting strategies and coordinating CVD research and training for Tanzania and the East African region. Conclusion There is a light of hope for long-term sustainable CVD research output from Tanzania, taking advantage of the ongoing activities and plans for the evolving EACoECVS. The Tanzanian experience can be taken as a lesson for other SSA countries.