Miracle-dz/UniFAR-FTUs huggingface dataset:
A Systematic Review of Circulatory microRNAs in Major Depressive Disorder: Potential Biomarkers for Disease Prognosis

Major depressive disorder (MDD) is a neuropsychiatric disorder, which remains challenging to diagnose and manage due to its complex endophenotype. In this aspect, circulatory microRNAs (cimiRNAs) offer great potential as biomarkers and may provide new insights for MDD diagnosis. Therefore, we systemically reviewed the literature to explore various cimiRNAs contributing to MDD diagnosis and underlying molecular pathways. A comprehensive literature survey was conducted, employing four databases from 2012 to January 2021. Out of 1004 records, 157 reports were accessed for eligibility criteria, and 32 reports meeting our inclusion criteria were considered for in-silico analysis. This study identified 99 dysregulated cimiRNAs in MDD patients, out of which 20 cimiRNAs found in multiple reports were selected for in-silico analysis. KEGG pathway analysis indicated activation of ALS, MAPK, p53, and P13K-Akt signaling pathways, while gene ontology analysis demonstrated that most protein targets were associated with transcription. In addition, chromosomal location analysis showed clustering of dysregulated cimiRNAs at proximity 3p22-p21, 9q22.32, and 17q11.2, proposing their coregulation with specific transcription factors primarily involved in MDD physiology. Further analysis of transcription factor sites revealed the existence of HIF-1, REST, and TAL1 in most cimiRNAs. These transcription factors are proposed to target genes linked with MDD, hypothesizing that first-wave cimiRNA dysregulation may trigger the second wave of transcription-wide changes, altering the protein expressions of MDD-affected cells. Overall, this systematic review presented a list of dysregulated cimiRNAs in MDD, notably miR-24-3p, let 7a-5p, miR-26a-5p, miR135a, miR-425-3p, miR-132, miR-124 and miR-16-5p as the most prominent cimiRNAs. However, various constraints did not permit us to make firm conclusions on the clinical significance of these cimiRNAs, suggesting the need for more research on single blood compartment to identify the biomarker potential of consistently dysregulated cimiRNAs in MDD, as well as the therapeutic implications of these in-silico insights.
Interaction of TOR and PKA Signaling in S. cerevisiae

TOR and PKA signaling are the major growth-regulatory nutrient-sensing pathways in S. cerevisiae. A number of experimental findings demonstrated a close relationship between these pathways: Both are responsive to glucose availability. Both regulate ribosome production on the transcriptional level and repress autophagy and the cellular stress response. Sch9, a major downstream effector of TORC1 presumably shares its kinase consensus motif with PKA, and genetic rescue and synthetic defects between PKA and Sch9 have been known for a long time. Further, studies in the first decade of this century have suggested direct regulation of PKA by TORC1. Nonetheless, the contribution of a potential direct cross-talk vs. potential sharing of targets between the pathways has still not been completely resolved. What is more, other findings have in contrast highlighted an antagonistic relationship between the two pathways. In this review, I explore the association between TOR and PKA signaling, mainly by focusing on proteins that are commonly referred to as shared TOR and PKA targets. Most of these proteins are transcription factors which to a large part explain the major transcriptional responses elicited by TOR and PKA upon nutrient shifts. I examine the evidence that these proteins are indeed direct targets of both pathways and which aspects of their regulation are targeted by TOR and PKA. I further explore if they are phosphorylated on shared sites by PKA and Sch9 or when experimental findings point towards regulation via the PP2ASit4/PP2A branch downstream of TORC1. Finally, I critically review data suggesting direct cross-talk between the pathways and its potential mechanism.
Studying the Superfluid Transformation in Helium 4 Through the Partition Function and Entropic Behavior

On this paper the authors study the behavior of Superfluid Helium 4 near and below the Lambda line deriving its partition function. The partition function is split into an interacting and a non-interacting/ideal part. Hence, the models about the Bose-Einstein Condensation of an ideal Bose-Gas are applied to the non-interacting/ideal part and then the results compared to the full superfluid, described by the quasiparticle approach. The transition from the Bose-Einstein to the Maxwell-Boltzmann statistics in the non-interacting part is exhibited extremely near the lambda transition of the actual superfluid Helium, hinting the effect of superfluidity in the ideal part of the system. Thus, the complete statistical model is now designed and calibrated by the known experimental data for its interacting part. With this model, since it is a theoretical method based on the partition function and entropy, not on the energy values of the quasiparticles, there is no theoretical limit to the lowest temperatures it can possibly describe. This entropic approach when extended well below the lambda-line, going near absolute zero, predicts the existence of an interatomic potential even at absolute zero, something that has been known to be the case for superfluid Helium. Overall, it seems that by the calculation of the authors the behaviors of superfluidity can also be observed and derived by studying the macroscopic variables, being the partition function and entropy in this way, thus offering a view of the superfluidity of the system through a different more macroscopical scope.
Energy Management Strategy for Hybrid Energy Storage Electric Vehicles Based on Pontryagin’s Minimum Principle Considering Battery Degradation

The development of energy management strategy (EMS), which considers how power is distributed between the battery and ultracapacitor, can reduce the electric vehicle’s power consumption and slow down battery degradation. Therefore, the purpose of this paper is to develop an EMS for hybrid energy storage electric vehicles based on Pontryagin’s minimums principle (PMP) considering battery degradation. To verify the EMS, the hybrid energy storage electric vehicle model is first established. In the meantime, the battery cycle life trials are finished in order to develop a battery degradation model. Following that, a rule-based control approach and the PMP optimization algorithm are used to allocate power in a hybrid energy storage system (HESS) in a reasonable manner. Finally, a simulation experiment under urban dynamometer driving schedule (UDDS) settings verifies the established EMS, and the findings reveal that the suggested EMS has a lower energy consumption rate and battery deterioration rate than the rule-based method.
Diversity and Phylogeny of Novel Cord-Forming Fungi from Borneo

Cord-forming (CF) fungi are found worldwide; however, tropical CF fungi are poorly documented. They play an essential role in forest ecosystems by interconnecting nutrient resources and aiding in the decomposition of plant matter and woody litter. CF fungi samples were collected from two forest conservation sites in the Sabah region of Malaysian Borneo. Sequencing and phylogenetic analysis of the ribosomal rRNA gene array 18S to 28S region from cords collected placed all of the collected specimens in Agaricomycetes (Basidiomycetes), specifically within the orders Trechisporales, Phallales, Hymenochaetales, Polyporales, and Agaricales. Comparison of the cord-derived sequences against GenBank and UNITE sequence databases, as well as phylogenetic analyses, revealed they were all novel sequences types. Many of these novel lineages were found to be closely related to other basidiomycetes commonly found in tropical forests, suggesting a large undiscovered tropical fungal diversity in Borneo that has been detected independently of sampling fruiting bodies. We show how these sequence types relate to the morphologies of the cords from which they were sampled. We also highlight how rapid, small-scale sampling can be a useful tool as an easy and relatively unbiased way of collecting data on cord-forming fungi in difficult-to-access, complex forest environments, independently of locating and sampling sporophores.
Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure

Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed patients and the appearance of depressive-like behaviors upon astrocytic dysfunctions in animal models. However, little is known about the importance of de novo generated astrocytes in the mammalian brain and in particular its possible involvement in the precipitation of depression and in the therapeutic actions of current antidepressants (ADs). Therefore, we studied the modulation of astrocytes and adult astrogliogenesis in the hippocampal dentate gyrus (DG) of rats exposed to an unpredictable chronic mild stress (uCMS) protocol, untreated and treated for two weeks with antidepressants—fluoxetine and imipramine. Our results show that adult astrogliogenesis in the DG is modulated by stress and imipramine. This study reveals that distinct classes of ADs impact differently in the astrogliogenic process, showing different cellular mechanisms relevant to the recovery from behavioral deficits induced by chronic stress exposure. As such, in addition to those resident, the newborn astrocytes in the hippocampal DG might also be promising therapeutic targets for future therapies in the neuropsychiatric field.
Risk and protective factors for the possible development of post-traumatic stress disorder among intensive care professionals in France during the first peak of the COVID-19 epidemic

ABSTRACT Background Intensive care units (ICU) are among the healthcare services most affected by the COVID-19 crisis. Stressors related to insecurity, unpredictability, patient death and family distress are significant, and put healthcare workers (HCWs) at high risk of post-traumatic stress disorder (PTSD). The aims of this study were to measure the prevalence of post-traumatic stress disorder in HCWs and to identify risk factors and protective factors during the epidemic in France. Methods During the first peak of the epidemic (from 22 April to 13 May 2020), we assessed sources of stress (PS-ICU scale), mental health (GHQ-12) and coping strategies (Brief-COPE). Three months later (03 June to 6 July 2020), PTSD was assessed using the IES-R scale, with additional questions about sources of support. Data were collected using self-report questionnaires administered online. Results Among 2153 professionals who participated in the study, 20.6% suffered from potential PTSD, mostly intrusion symptoms. Risk factors for the development of PTSD were having experienced additional difficult events during the crisis, having a high level of psychological distress, a high level of perceived stress related to the workload and human resources issues, the emotional burden related to the patient and family, and stressors specific to COVID-19 during the first peak of the crisis. The use of positive thinking coping strategies decreased the relationship between perceived stress and the presence of PTSD, while social support seeking strategies increased the relationship. Finally, the HCWs preferred to use support from colleagues, relatives and/or a psychologist, and very few used the telephone hotlines. Conclusion The epidemic has had a strong traumatic impact on intensive care HCWs. Given the risk of PTSD, we need to consider implementing easily-accessible support services that focus on positive thinking coping strategies, during and after the crisis. HIGHLIGHTS The risk of PTSD is high among intensive care professionals. Perceived stress and psychological distress during the first peak of crisis increased the likelihood of subsequent PTSD. Support for professionals should be easily available and focused on positive thinking strategies.
Transitional and small aquatic cave habitats diversification based on protist assemblages in the Veternica cave (Medvednica Mt., Croatia)

Protists in caves are scarcely researched. Most cave studies address the diversity of protists, but very little is known about their habitats and spatio-temporal dynamics. The aim of this study was to investigate the diversity and abundance of protists in the Veternica cave in the Medvednica mountain in Croatia on hygropetric and sinter and clay pools during six months. During this study, 47 protists taxa were distinguished belonging to the groups of heterotrophic flagellates, ciliates, heliozoans, stramenopiles and testate and naked amoebae. The highest taxon richness was found at the sinter pool site richest in bats guano (36 taxa). Most diverse were testate amoebae and ciliates. The number of taxa and their abundance differed significantly between the sampling sites. The prospected habitats supported different protist assemblages, proved by ordination analysis. The most distinctive habitat was the hygropetric. Habitat heterogeneity could be attributed to the presence of inorganic and organic sediments at the sites and habitat microhydrology (lotic or lentic system). Kendall’s concordance coefficient showed a good synchronicity between the habitats in the Veternica cave, based on taxon richness and abundance of protists indicating similar seasonal trends. Seasonality in the studied habitats is attributed to the hydro-meteorological conditions in the Veternica cave drainage area. This study is one of the few studies of spatio-temporal diversity and abundance of protists in caves. Despite the similar appearance of small transitional and aquatic habitats in caves, an example of this study showed specific habitat diversification.
A DSS Model with Business Intelligence Reporting Facilities

When it comes to develop a Decision Support System that must enhance nowadays Business Intelligence concepts and reporting facilities, the job could be easier if not trying to "reinvent the wheel'. In order to do so, this paper actually gives some practical examples of how to use a simple development tool and its extensions, what to include and, above all, when to reinvent. The pretended novelty also concerns the idea of interaction with Geographical Information Systems and not only.
Expert Consensus Document: Diagnosis for Chronic Constipation with Faecal Retention in the Rectum Using Ultrasonography

Chronic constipation is a common gastrointestinal disorder in older adults, and it is very important to manage chronic constipation. However, evaluating these subjective symptoms is extremely difficult in cases where patients are unable to express their symptoms because of a cognitive or physical impairment. Hence, it is necessary to observe the patient’s colonic faecal retention using objective methods. Ultrasonography observation for colonic faecal retention is useful for diagnosing constipation and evaluating the effectiveness of treatment. Since there was no standard protocol for interpreting rectal ultrasonography findings, we developed an observation protocol through an expert consensus. We convened a group of experts in the diagnosis and evaluation of chronic constipation and ultrasonography to discuss and review the current literature on this matter. Together, they composed a succinct, evidence-based observation protocol for rectal faecal retention using ultrasonography. We created an observation protocol to enhance the quality and accuracy of diagnosis of chronic constipation, especially rectal constipation. This consensus statement is intended to serve as a guide for physicians, laboratory technicians and nurses who do not specialise in ultrasound or the diagnosis of chronic constipation.
Bifrontal Osteoplastic Flap: An Option to Decrease Infection in Bifrontal Craniotomies with Skull Base Osteotomies

Infection can be a common complication following bifrontal craniotomy with skull base osteotomies given the potential violation of sinuses and entry into the nasal structures. Our objective was to examine our series of patients who underwent a bifrontal craniotomy with skull base osteotomies and describe the infection rate. We propose the bifrontal osteoplastic flap as an adjunct to infection prevention. A retrospective single-center study of a patient database was performed. Twenty patients were identified. Fifty-five percent were male. The mean age was 55.7 ± 13.9 years. The most common indications for surgery were esthesioneuroblastomas (35%) and anterior skull base meningiomas (30%). Six patients (30%) developed an infection, 1 patient (5%) developed a CSF leak, and no patients developed a mucocele. All 6 infected cases had nasal pathology with intracranial extension, they all received chemoradiation post-operatively and were all combined cases with otorhinolaryngology. Eighty-three percent of these patients required a craniectomy and all of them required long-term IV antibiotics. Infection is not uncommon after a bifrontal craniotomy with skull base osteotomies and the use of the bifrontal osteoplastic flap in cases where the risk of infection is high, i.e., esthesioneuroblastomas surgery, may help reduce said risk and lead to better patient outcomes.
The Bright Side of the Tiger: Autofluorescence Patterns in Aedes albopictus (Diptera, Culicidae) Male and Female Mosquitoes

Light-based events in insects deserve increasing attention for various reasons. Besides their roles in inter- and intra-specific visual communication, with biological, ecological and taxonomical implications, optical properties are also promising tools for the monitoring of insect pests and disease vectors. Among these is the Asian tiger mosquito, Aedes albopictus, a global arbovirus vector. Here we have focused on the autofluorescence characterization of Ae. albopictus adults using a combined imaging and spectrofluorometric approach. Imaging has evidenced that autofluorescence rises from specific body compartments, such as the head appendages, and the abdominal and leg scales. Spectrofluorometry has demonstrated that emission consists of a main band in the 410–600 nm region. The changes in the maximum peak position, between 430 nm and 500 nm, and in the spectral width, dependent on the target structure, indicate the presence, at variable degrees, of different fluorophores, likely resilin, chitin and melanins. The aim of this work has been to provide initial evidence on the so far largely unexplored autofluorescence of Ae. albopictus, to furnish new perspectives for the set-up of species- and sex-specific investigation of biological functions as well as of strategies for in-flight direct detection and surveillance of mosquito vectors.
Decision-making support system for automatic vessel anti-grounding and anti-reef

Using Electronic Chart Display and Information System(ECDIS) as an effective and reliable information source of static targets and intermedium for realizing the organic combination of dynamic and static information for vessel anti-collision,the study on decision-making support system for automatic vessel anti-grounding and anti-reef is carried out.A rectangular area model is suggested for searching the information of dangerous static obstructions,and an algorithm for decision-making for automatic vessel anti-grounding and anti-reef is illustrated.Mathematical models for determining threshold of dangerous water depth and parameters of the search area are provided in detail.Finally,computer simulation tests on the navigational process of automatic vessel anti-grounding and anti-reef are carried out on a simulation platform with the name of "navigation safety and automatic collision avoidance simulation test platform" which is based on the ship maneuver simulating model and ECDIS.The simulation result indicates that the algorithm of decision-making is of good self-adaptability.
Measurement of fiber length, coarseness, and shape with the fiber quality analyzer

Fiber length, coarseness, and fiber curl index were measured for a variety of papermaking pulps using a new commercial instrument, the fiber quality analyzer (FGA). The results were compared with measurements obtained using other available methods. The fiber length measurements obtained with the FGQ were similar to those reported by the Kajaani FS-200 fiber-length analyzer. Coarseness measurements obtained with the FQA were similar to results from both the FS-100 and the manual TAPPI method (TAPPI T 234 cm-84). Fiber curl index as measured by the FQA was approximately 20% lower than manual measurements obtained using image analysis. Repeatability and interlaboratory reproducibility data are reported for 3 samples at 11 laboratories. The FQA flow cell operated without plugging problems, suggesting that it is suitable for on-line measure ments. Application: Evaluates the precision and accuracy of measurements of fiber length, coarseness, and curl as reported by the recently developed fiber quality analyzer.
Motivations and barriers in becoming urban residents: Evidence from rural migrants living in public rental housing in Chongqing, China

ABSTRACT The city of Chongqing in southwestern China has adopted a systematic set of urbanization policies since the late 2000s. Due to their emphasis on the role of the government and their scale, they deserve close attention. Yet, few studies have examined both positive and negative impacts of the urbanization policies regarding land acquisition, hukou conversion and urban housing as a complete process from rural migrants’ perspective. More longer-term empirical studies focusing on rural migrants’ reactions to the urbanization policies are needed. By conducting interviews with rural migrants, this paper aims to fill this gap. The results show that the migration intentions of rural migrants living in public rental housing are well-organized and purposive. The motivations for migration are not exclusively financial, but include the opportunities for better schooling and enhanced family bonds that come with living in public rental housing. Meanwhile, the institutional and social barriers faced by rural migrants were also identified. The goal of the paper is to enrich the understandings of the effects of urbanization policies in China.