Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of leptin on GABA content and receptor expression in hypothalamus of mice with sleep deprivation

[Abstract] Objective To observe the effects of the adipocyte hormone leptin on GABA content and receptor expression in hypothalamus of mice with sleep deprivation, and explore the possible mechanisms. Methods M ale C57BL/6 mice were randomly divided into three groups (8 each): control group, sleep deprivation (SD) group and leptin supplement (L-SD) group. Mice in control group were set up in a water environment without sleep deprivation, mice in SD group were set up in a "modified multi-platform water environment" to establish a sleep deprivation model, and mice in L-SD group were given leptin 1.3 mg/kg intraperitoneally twice daily in conjunction with sleep deprivation. Seven days after sleep deprivation, the general conditions of mice were observed, body weight was measured and hypothalamic tissues and plasma specimens were collected. ELISA was used to detect the plasma leptin levels, hypothalamic γ -aminobutyric acid (GABA) and glutamate (Glu) contents. Western blotting was performed to detect the expression levels of GABA key glutamate decarboxylase 67 (GAD67) and GABAA receptor α 1 subtype protein (GABAAR α 1 ). Results Compared with control group, the weight of mice in SD group significantly reduced [(22.03 ± 0.42) g vs. (17.75 ± 0.75) g, P < 0.01], while the weight of mice in L-SD group [(15.10 ± 0.38) g] significantly reduced compared with that in control group and SD group ( P < 0.01). The mice in SD group lost their smooth hair, were particularly sensitive to light and sound, and were slightly manic and aggressive; Compared with control group, the plasma leptin level in mice of SD group significantly reduced [(483.81 ± 21.72) ng/ml vs. (359.14 ± 16.69) ng/ml, P < 0.01], and the hypothalamic GABA level significantly reduced [(152.37 ± 8.14) ng/g vs. (111.31 ± 2.96) ng/g, P < 0.05]. GABA levels of mice hypothalamus in L-SD group [(132.19 ± 3.38) ng/g] were significantly higher than that in SD group [(111.31 ± 2.96) ng/g, P < 0.05], but no statistical difference was when compared with that in control group ( P > 0.05). The hypothalamic Glu levels were obviously higher in SD group [(686.56 ± 10.01) ng/g] and L-SD group [(668.64+9.93) ng/g] than that in control group [(577.11 ± 16.36) ng/g] ( P < 0.05), but no statistical significance was found when compared between SD group and L-SD group ( P > 0.05). The expressive levels of GAD67 and GABAAR α 1 protein in the hypothalamus of mice in SD group [0.68 ± 0.06, 0.69 ± 0.07] were significantly lower than that in control group (1.09 ± 0.13, 0.99 ± 0.07) ( P < 0.05); While the expressive levels of GAD67 and GABAAR α 1 proteins in the hypothalamus of mice in L-SD group (1.39 ± 0.19 and 1.33 ± 0.14, respectively) were significantly higher than those in SD group and control group ( P < 0.05). Conclusion Leptin can up-regulate the expression of the key GABA synthase GAD67, increase the content of GABA and the expression of GABAAR α 1 protein in hypothalamus of sleep-deprived mice, which may be an important mechanism of leptin affecting sleep.
Etiology of atrioventricular block visualized by cardiac magnetic resonance

bundle branch block Transthoracic echocardiography showed normal cardiac anatomy, normal coronary artery origins, but anomalous left ventricular function with hypokinetic mid inferoseptal and apical septal segments and dyskinetic basal and mid inferoseptal segments, the latter also with hyperechogenic myocardium. Laboratory showed neutrophilia of 12 [1.5 – 8.5] G/L, greatly elevated troponin T of 9.54 [<0.014] mcg/L, LDH of 16505 [<236] U/L, NT-proBNP of 17734 [<390] ng/L, and a mildly elevated C-reactive protein of 27 [<10] mg/L.
Molecular and phenotypic analysis of the gene identifies a family of related glycosyltransferases

The Saccharomyces cerevisiae mnnlO mutant is defective in the synthesis of A'-linked oligosaccharides (Ballou et al., 1989). This mutation has no effect on O-linked sugars, but results in the accumulation of glycoproteins that contain severely truncated /V-linked outer-chain oligosaccharides. We have cloned the MNN10 gene by complementation of the hygromycin B sensitivity conferred by the mutant phenotype. Sequence analysis predicts that MnnlOp is a 46.7 kDa type II membrane protein with structural features characteristic of a glycosyltransferase. Subcellular fractionation data indicate that most of the MnnlO protein cofracti-onates with Golgi markers and away from markers for the endoplasmic reticulum (ER), suggesting MnnlOp is localized to the Golgi complex. A comparison of the MnnlO protein sequence to proteins in the two different databases identified five proteins that are homologous to MnnlOp, including a well characterized Schizosaccharomyces pombe al,2 galactosyltransferase that resides in the Golgi complex. Taken together, these results suggest that MNN10 encodes a novel Golgi-localized mannosyltransferase contained in this previously unrecognized family of related sugar transferases.
markers under The markers of platelet functions and von willebrand factor serum content from patients with type 2 diabetes mellitus and ischemic stroke

— Introduction : The est і mated number of people with diabetes worldwide in 2015 is 415 million persons, up to 91% of adults hadtype 2 diabetes and the crude incidence of stroke among patients with diabetes of the 2 nd type can be more than 3 times that in the general population. It is known platelet activation and aggregation are critical in the pathogenesis of acute ischemic cerebrovascular diseases. Thus to examine the evidence of platelet functioning such as platelet count,aggregation in response to ADP, coagulation von Willebrand factor and serotonin content, monoamine oxidase (MAO) activity in the blood of patients with ischemic stroke and with ischemic stroke complicated with the 2 nd type diabetes are the aim of the present study. Methods: The platelet aggregation was assayed for photo-optical aggregometer, von Willebrand factor was determined by Elisa, serotonin determination included ion-exchange chromatography and fluorescence spectrophotometry. Determination of monoamine-oxidase serum activity was spectophotometry. Results: The investigation has shown an increase of serotonin and Von Willebrand factor blood content in both groups of patients with ischemic stroke andtype 2 diabetes and stroke alone compared with the values of the control group. The monoamine oxidase activity and platelet count were reduced in blood of patients with diabetes of the 2 nd type with ischemic stroke against to the values from the group of healthy donors. Platelet aggregation in response to ADP increased under the investigated pathologies. Conclusions: These obtained data suggested a significant imbalance in vascular platelet element of hemostasis under the ischemic stroke and amplification of negative changes under the stroke with the 2 nd type diabetes.
Organisational Leadership and Style Adopting in the Hospitality Industry

The importance of organisational leadership has been the fundamental step to the success of firms, even for the global and dynamic industries. By and large, firms within the hospitality industry understanding this concept have yet to put this in practice globally as well as in the local markets for meeting the success especially those firms that are in the process of striving to become industry leaders. The hospitality industry is complex, dynamic, and global thus it becomes challenging for the firms of this industry to sustain the continuous development and competitiveness that’s happening continuously. This article reviews the literature concerning the organisational leadership adopting in the hospitality industry. Comprehensive search was made and reviewed the literature from which were selected, organized, and analysed accordingly. This review paper delves into the concept of organisational leadership and its characteristics, while highlighting the steps taken by few such firms in the hospitality industry which will help in identifying and setting the standards of organisational leadership globally. The leadership perspective is discussed in the context of the Indian hospitality industry to highlight how the concept can be applied to developing markets for meeting the success to become pioneers of the industry.
Toxicidade de nanomateriais de ZnO decorados com Ag em Daphnia magna Toxicity of Ag decorated ZnO nanomaterials to Daphnia magna

Nanotechnology is a rising field and nanomaterials (NMs) can now be found in a vast variety of products that can go from medical equipment to cosmetics. NMs attract much attention due to their high reactivity, a result of high surface area to volume ratio. They can present different chemical compositions, sizes and shapes which can alter their behaviour. Due to their increase of production and presence in consumer products, NMs can end up in the environment due to unintentional or intentional release. Although many studies have focused on the toxicity of NMs, different results can be found for NMs with the same chemical composition. This is due to the fact that abiotic and biotic factors can alter the NMs bioavailability and therefore their toxicity, along with the diversity of their inherent characteristics. The presence of other NMs or chemicals in the environment can also affect NMs toxicity, increasing or decreasing their toxicity. Also, new nanomaterials combining NMNM are being development due to their enhancing characteristics when compared to NMs or nanoparticles (NPs) alone. Therefore, it is important to understand how they will behave in the environment. Taking this into account, the main objective of this work was to evaluate the toxicity of a NM composed by ZnO-NM with Ag-NP on its surface (ZnO/Ag-NM) and try to understand if its toxicity can be predicted by the toxicity of the single components. With this purpose, the toxicity in Daphnia magna was evaluated to ZnO-NM and Ag-NP as single components, as a laboratory mixture and then compared to the toxicity of the ZnO/Ag-NM. To assess toxicity, immobilization and reproduction tests were performed. Also, the mixture toxicity and the toxicity of the ZnO/Ag-NM were analysed using the MixTox tool, based on the concentration addition model and possible deviations for synergism/antagonism (S/A), dose-level (DL) and dose-ratio (DR) were explored. ZnO-NM and Ag-NPs showed an increase toxicity to Daphnia magna with increasing concentrations. Decrease of survival after 48h and decrease in the number of neonates produce during 21 days were observed for both NMs with Ag-NPs demonstrating the highest toxicity. The mixture exposures showed a deviation dependency on the doses used (DL) for immobilisation and for reproduction a synergism deviation was observed. ZnO/Ag-NM showed higher toxicity when comparing to the ZnO-NM alone. When analysing the results with the MixTox tool a deviation dependent on the chemical present (DR) was observed for immobilization and a dose level deviation (DL) for reproduction. This study demonstrates that both, the mixture and the ZnO/Ag-NM, will not behave as their components and the toxicity cannot be predicted by them, highlighting the importance of taking into account the interaction NM-NM when assessing NMs toxicity.
COMMENT 3-Adrenoceptor timulation on Top of 1-Adrenoceptor Blockade Stop or Encore ? ” *

atecholamines released by the orthosympathetic system lay a major role in the shortand long-term regulation of ardiac function. Although acute stimulation of adrenergic eceptors (ARs) (mostly 1) increases all aspects of cardiac ontractility and is generally considered as positive for heart unction, their prolonged activation results in adverse reodeling of the myocardium, in part due to toxic effects on ardiomyocytes (and other cells composing cardiac muscle), s exemplified by the cardiac phenotype of mice with ardiac-specific overexpression of 1-AR (1). Accordingly, hronic overactivation of the orthosympathetic system in eart failure, albeit initially adaptive, is generally considered o be deleterious in the long term (2). This is amply upported by clinical evidence of the beneficial effect of -adrenergic blockade in failing patients.
The value of the time delay delta T (A,B) for the 'double' quasar 0957+561 from optical photometric monitoring.

Une etude photometrique des images A et B du quasar «double» 0957+561 a ete effectuee de 1980 a 1987 et un retard de temps de parcours Δt(A,B)=415±20 j a ete trouve avec un pic de correlation significatif. Le resultat est compatible avec la prediction deduite de l'hypothese du mirage gravitationnel
Catalytic Function of an (cid:2) / (cid:3) Hydrolase Is Required for Energy Stress Activation of the (cid:4) B Transcription Factor in Bacillus subtilis

The general stress response of Bacillus subtilis is controlled by the (cid:1) B transcription factor, which is activated in response to diverse energy and environmental stresses. These two classes of stress are transmitted by separate signaling pathways which converge on the direct regulators of (cid:1) B , the RsbV anti-anti- (cid:1) factor and the RsbW anti- (cid:1) factor. The energy signaling branch involves the RsbP phosphatase, which dephosphorylates RsbV in order to trigger the general stress response. The rsbP structural gene lies downstream from rsbQ in a two-gene operon. Here we identify the RsbQ protein as a required positive regulator inferred to act in concert with the RsbP phosphatase. RsbQ bound RsbP in the yeast two-hybrid system, and a large in-frame deletion in rsbQ had the same phenotype as a null allele of rsbP —an inability to activate (cid:1) B in response to energy stress. Genetic complementation studies indicated that this phenotype was not due to a polar effect of the rsbQ alteration on rsbP . The predicted rsbQ product is a hydrolase or acyltransferase of the (cid:2) / (cid:3) fold superfamily, members of which catalyze a wide variety of reactions. Notably, substitutions in the presumed catalytic triad of RsbQ also abolished the energy stress response but had no detectable effect on loga- rithmic
Merger & Acquisition Effect on Management Pay 2020

CEO compensation has gathered a lot of attention in recent years, following extreme growth and news of record-breaking salaries. At the same time, Merger & Acquisition (hereafter M&A) activity has accelerated in amount and deal size. Several researchers have tried to quantify and discuss the link between management compensation and M&A, including discussion areas such as established theories of agency problem as well as managerial power and a lot of research done globally to understand the relationship between M&A deal and compensation. However, there is only some limited research looking at the effect of M&A on management compensation in Swedish market. Based on this fact, the purpose of this thesis is to investigate M&A effects on management compensation by analysing listed companies in Nasdaq Stockholm Stock Exchange. A regression and chow test are performed to examine the M&A deal influence on compensation. The empirical findings support the proposition that M&A positively influences compensation. Further, the findings validate previous research that company size, by proxy of firm total assets, has a significant influence on management compensation.
Holographic phase transition of QCD with back-reaction of flavors

We revisit confinement/deconfinement transition in holographic QCD to consider the back-reaction of a bulk scalar field. The bulk scalar field is dual to a quark bi-linear operator $\bar qq$, and it encodes explicit and spontaneous chiral symmetry breaking of QCD. To perform the Hawking-Page transition analysis with the back-reaction, we first obtain a deformed AdS black hole solution due to a finite quark mass. Through the Hawking-Page analysis with the back-reacted geometry, we study the flavor number $N_f$ and finite quark mass dependence of the critical temperature of the QCD confinement/deconfinement transition. In addition, we confirm that unphysical QCD phase haunting around in a previous study disappears with the back-reaction. We discuss our results in the light of lattice QCD observations.
Penggunaan Dual-Layer Substrate untuk Meningkatkan Bandwidth Antena Mikrostrip pada Frekuensi LTE

Narrow bandwidth is one of the problems in a microstrip antenna. Bandwidth enhancement is proposed by applying dual-layer in the substrate. The bottom layer is made from a single-layer circular microstrip antenna design by applying the formula to get an initial dimension and then it is simulated by an EM Simulator to verify its performance whether meet the specific requirement. The dimension of optimized design is used as a dimension for the top layer but without the ground plane. The antenna uses substrate FR4 which has thickness of 1.6 mm with dielectric constant of 4.3. The simulation result of the dual-layer antenna in frequency band 40 LTE shows that there is an additional bandwidth of 46% with return loss -23.45 dB, antenna gain 0.34 dB and directional radiation pattern. Keywords : Microstrip Antenna, Return Loss and Dual-layer
Statistical ﬂuctuations in HfO x resistive-switching memory (RRAM): Part II - Random telegraph noise

—A key concern for resistive switching memory (RRAM) is the read noise, due to the structural, chemical and electrical modiﬁcations taking place at the localized current path, or conductive ﬁlament (CF). Read noise typically appears as a random telegraph noise (RTN), where the current randomly ﬂuctuates between ON and OFF levels. This work addresses RTN in RRAM, providing physical interpretations and models for the dependence on the programming and read conditions. First, we explain the RTN dependence on the compliance current during set transition in terms of the size-dependent depletion of carriers within the CF. Then we discuss the bias-dependence of the RTN switching times and amplitude, which can be explained by Joule heating and Poole-Frenkel (PF) barrier modiﬁcations arising from the electrostatics of the RTN ﬂuctuating center.
Bulk and surface recombination in InAs/AlAs0.16Sb0.84 3.45 μm light emitting diodes

A study of the light generation efficiency of a series of InAs/AlAs0.16Sb0. 84 light emitting diodes with p-type InAs active layers is reported. The bulk low-injection radiative efficiency of the p-type material is shown to be as high as 24% at a hole concentration of 1.5×1017 cm−3 but to decrease with increasing hole concentration in a manner consistent with the dominant low-injection nonradiative processes being Auger processes with two holes in their initial states and a total rate constant of 2×10−28 cm6 s−1. The maximum internal low-drive quantum efficiency achieved in the light emitting diodes is shown to be limited by interface recombination at the InAs/AlAs0.16Sb0. 84 heterojunction and reabsorption in the active layer in addition to the bulk nonradiative processes in the InAs. A maximum value of ∼9% is achieved.
A directional circularly polarized crossed‐dipole antenna with bandwidth enhancement

A broadband circularly polarized antenna based on the crossed‐dipole structure is designed. The antenna consists of a pair of dual‐side printed crossed dipoles, a loop phase delay line, and a parasitic patch. By modifying the configuration of the dipoles and introducing a parasitic patch, a wide axial ratio (AR) bandwidth is obtained. A defected ground plane is designed, which has a significant improvement in extending the 3‐dB AR bandwidth and enhances the gain. The proposed prototype is manufactured and measured for validation. Measured results show that the antenna achieves both −10 dB impedance bandwidth and 3‐dB AR bandwidth of 68.6% (2.3–4.7 GHz). Moreover, the average gain of the antenna is about 8 dBi within the operating band, with a floating less than 2 dB.
Topological Classification-Based Splitting–Combining Methodology for Analysis of Complex Multi-Loop Systems and Its Application in LDOs

Multiple loops have been used extensively to enhance the system performance in various applications. However, the increasing complexity of multi-loop systems also makes them much more difficult to analyze and implement. In this paper, a new methodology to analyze multi-loop system is proposed. In the proposed framework, multi-loop systems are regarded to be built upon of sub-modules of cascade, parallel adding, and feedback units, and then, they are simplified following a certain procedure based on the correlation of the Bode characteristics of the segmented sub-modules. Applying this methodology, the Bode plot and the transfer function of the system can be easily obtained with the system properties of gains, zeros, and poles. Two examples are provided as demonstrators, including a multi-loop low-dropout regulator (LDO) from literature, and a newly designed multi-loop LDO aiming at enhancing the stability over a wide load range, which show that the Bode plot and the transfer function can be obtained more intuitively and rapidly. Excellent agreements among theory, simulations, and measurements are confirmed, which verify the proposed method. It can help designers to gain more intuitions and insights on multi-loop systems from both circuit and device perspectives, which is also an effective tool for both stability analysis and circuit design.
How Firms and Experts View The Phillips Curve: Evidence from Individual and Aggregate Data from South Africa

ABSTRACT Heterogeneity is now a regular part of macroeconomic theory, but disaggregated data about firm expectations remain scarce. A survey of firms and financial analysts in South Africa provides forecasts of inflation and other macroeconomic variables. We estimate a variety of inflation and wage growth-based Phillips curves, which reflect differences in how firms and financial analysts view the link between inflation and real economic activity, as well as heterogeneity across firms. South African Phillips curves have become flatter, but backward-looking factors remain more relevant for firms. Rising real wage growth exceeds expected and past inflation and wage growth since the GFC.
Gear Defect through Hilbert–Huang Transform Analysis of Gearbox Vibration Signals

Targeting the feature extraction of the gear fault vibration, Hilbert–Huang transform (HHT) analysis is introduced into the gear fault diagnosis in rotating machinery. The concept of the instantaneous energy in time-frequency analysis, based on Hilbert time-frequency spectrum, was used to measure the energy distribution of the signal in time-frequency domain. The gear vibration signal is decomposed into a series of intrinsic mode functions (IMFs), which are band limited and the frequency families are separated effectively according to the signal characteristics with empirical mode decomposition. The fault feature of the gear vibration signal can be extracted effectively from Hilbert time-frequency spectrum which can represent the instantaneous frequency of the gear vibration signal with the change of the time. The analysis results from the experimental vibration signal show that HHT analysis can extract the character.