Miracle-dz/UniFAR-FTUs huggingface dataset:
EC ENDOCRINOLOGY AND METABOLIC RESEARCH The Prevalence and Determinants of Obesity among Physicians in Primary Health Care Centers in Jeddah

Introduction: Overweight and Obesity are well documented in the literature. Their high prevalence rates and the high risk of devel-oping chronic non-contactable diseases such as cardiovascular diseases, diabetes, hypertension, and hyperlipidemia are also well known. Furthermore, there has been an increase in the prevalence of obesity and overweight in Saudi Arabia in particular. However, there is very limited information about the prevalence of these two terms among healthcare physicians in Jeddah in Saudi Arabia. Therefore, we conducted this study in order to estimate the prevalence of obesity among physicians in Jeddah and to document any significant risk factors. Materials and Methods: This cross-sectional survey study was conducted from 1 st of June to the 1 st of September 2018 among non-pregnant physicians of both genders in Jeddah. Eligible individuals were given a self-administered questionnaire to fill. The question naire included the body mass index data, diet and food habits, and physical activity in general. Results: A total of 202 physicians comprised our population. The mean weight was 72.75 ± 18.55 kg, whereas, the mean height was 165.69 ± 8.93 cm. The mean body mass index (BMI) for all physicians was 26.3 ± 5.35 Kg/m 2 . The prevalence of obesity was 23% and overweight was 32%. Impaired physical activity was noted in the majority of subjects (82%), while fully active subjects were 18%. From all analyzed risk factors, male gender (P-value = 0.002) and increase in age (P-value = 0.001) were the only significantly correlated factors. Among nutritional items, only soft drinks without sugar was significantly correlated with overweight and obesity (P-value < 0.05). As regards the level of physical activity, no significant correlated with obesity was noted (P-value = 0.83). Conclusion: There is a high prevalence of obesity among healthcare workers in Jeddah which should be cautiously addressed in further work and prevention programs.
Title : Knowledge, attitudes and eating habits on red and processed meat among gym users: a cross-sectional survey.

Aims In 2015, the International Agency for Research on Cancer classified red meat (RM) and processed meat (PM) intakes as “probably carcinogenic” and “carcinogenic” to humans, respectively. The aim of the study was to evaluate eating behaviours and knowledge on the potential risks of RM-PM consumption among gym users. In 2018, a cross-sectional survey was conducted in 20 gyms in Turin using a 48-items questionnaire assessing socio-demographic, sports, dietary information and knowledge about RM-PM (sample size=298). Multivariable logistic and linear regressions were performed. The significance level was p ≤ 0.05.
(2013) Modelling and control of a multi-stage interleaved DC-DC converter with coupled inductors for super-capacitor

Interleaved converters with coupled inductors are widely used to share load current in high power applications. It offers high equivalent switching frequency and reduced output current ripples using small size magnetic components. Due to smaller common-mode inductance, control system can be designed to achieve fast dynamic response. This paper proposes 8 channel interleaved DC/DC converter for interfacing super-capacitor energy storage system to a 400 V DC voltage bus. Multi-stage interleaving magnetic circuit with two-phase coupling inductor as a building block is proposed. A methodology is developed to construct the model of the multi-stage magnetic circuit from the basic two-phase coupled inductor model. The derived model is successfully used to evaluate the system power losses and to design the magnetic circuit parameters and its current controller to fulﬁl the DC/DC converter steady state and dynamic performance speciﬁcations. A 20 kW/four stage/ 8 channel DC/DC converter laboratory prototype has been built to connect a super-capacitor stack to 400 V DC voltage bus. Experimental investigation validates the modeling, the system losses calculations and the design speciﬁcations of the system.
Update on electron-cloud power deposition for the Large Hadron Collider arc dipoles ∗

We revisit the estimation of the power deposited by the electron cloud (EC) in the arc dipoles of the LHC by means of simulations. We adopt, as simulation input, a set of electron-related parameters closely resembling those used in recent simulations at CERN [1]. We explore values for the bunch population N b in the range 0 . 4 × 10 11 ≤ N b ≤ 1 . 6 × 10 11 , peak secondary electron yield (SEY) δ max in the range 1 . 0 ≤ δ max ≤ 2 . 0, and bunch spacing t b either 25 or 75 ns. For t b = 25 ns we ﬁnd that the EC average power deposition per unit length of beam pipe, d ¯ P/dz , will exceed the available cooling capacity, which we take to be 1.7 W/m at nominal N b [2], if δ max exceeds ∼ 1.3, but d ¯ P/dz will be comfortably within the cooling capacity if δ max ≤ 1 . 2. For t b = 75 ns d ¯ P/dz exceeds the cooling capacity only when δ max > 2 and N b > 1 . 5 × 10 11 taken in combination. The rediﬀused component of the secondary electron emission spectrum plays a signiﬁcant role: if we artiﬁcially suppress this component while keeping δ max ﬁxed, d ¯ P/dz is roughly cut in half for most values of N b explored here, and in this case we ﬁnd good agreement with the results in Ref. 1, as expected. We provide a fairly detailed explanation of the mechanism responsible for such a relatively large eﬀect. We assess the sensitivity of our results to numerical simulation parameters, and to physical parameters such as the photoelectric yield, bunch train length, etc. Owing to the lack of detailed knowledge of the electron emission spectrum, the sensitivity of d ¯ P/dz to the rediﬀused component appears to be the most signiﬁcant source of uncertainty in our results. Nevertheless, taking our results as a whole, the condition δ max ≤ 1 . 2 seems to be a conservative requirement for the cooling capacity not to be exceeded.
OVEROXIDATION OF 2-CYS PEROXIREDOXIN IN PROKARYOTES: CYANOBACTERIAL 2-CYS PEROXIREDOXINS SENSITIVE TO OXIDATIVE STRESS

María B. Pascual, Alejandro Mata-Cabana, Francisco J. Florencio, Marika Lindahl, and Francisco J. Cejudo From Instituto de Bioquímica Vegetal y Fotosíntesis, Universidad de Sevilla and CSIC, Running head: Overoxidation of prokaryotic 2-Cys Prx Address correspondence to: Francisco J. Cejudo, Instituto de Bioquímica Vegetal y Fotosíntesis, Avda Américo Vespucio 49, 41092-Sevilla, Spain, FAX: 34-954460065; E-mail: fjcejudo@us.es
Low- and High-Density Lipoproteins Modulate Function, Apoptosis, and Proliferation of Primary Human and Murine Pancreatic (cid:1) -Cells

A low high-density lipoprotein (HDL) plasma concentration and the abundance of small dense low-density lipoproteins (LDL) are risk factors for developing type 2 diabetes. We therefore investigated whether HDL and LDL play a role in the regulation of pancreatic islet cell apoptosis, proliferation, and secretory function. Isolated mouse and human islets were exposed to plasma lipoproteins of healthy human donors. In murine and human (cid:1) -cells, LDL decreased both proliferation and maximal glucose-stimulated insulin secretion. The comparative analysis of (cid:1) -cells from wild-type and LDL receptor-deficient mice revealed that the inhibitory effect of LDL on insulin secretion but not proliferation requires the LDL receptor. HDL was found to modulate the survival ofbothhumanandmurineisletsbydecreasingbasalaswellasIL-1 (cid:1) andglucose-inducedapoptosis. IL-1 (cid:1) -induced (cid:1) -cell apoptosis was also inhibited in the presence of either the delipidated protein or the deproteinated lipid moieties of HDL, apolipoprotein A1 (the main protein component of HDL), or sphingosine-1-phosphate (a bioactive sphingolipid mostly carried by HDL). In murine (cid:1) -cells, the protective effect of HDL against IL-1 (cid:1) -induced apoptosis was also observed in the absence of the HDL receptor scavenger receptor class B type 1. Our data show that both LDL and HDL affect function or survival of (cid:1) -cells and raise the question whether dyslipidemia contributes to (cid:1) -cell failure and hence the manifestation and progression of type 2 diabetes mellitus. ( Endocrinology 150: 4521–4530, 2009)
In vivo multiphoton microscopy of

Melasma is a skin disorder characterized by hyperpigmented patches due to increased melanin production and deposition. In this pilot study we evaluate the potential of multiphoton microscopy (MPM) to characterize non-invasively the melanin content, location, and distribution in melasma and assess the elastosis severity. We employed a clinical MPM tomograph to image in-vivo morphological features in melasma lesions and adjacent normal skin in 12 patients. We imaged dermal melanophages in most dermal melasma lesions and occasionally in epidermal melasma. The melanin volume fraction values measured in epidermal melasma (14±4%) were significantly higher (p<0.05) than the values measured in peri-lesional skin (11±3%). The basal keratinocytes of melasma and perilesions showed different melanin distribution. Elastosis was predominantly more severe in lesions than in perilesions and was associated with changes in melanin distribution of the basal keratinocytes. These results demonstrate that MPM may be a non-invasive imaging tool for characterizing melasma. inflammatory response, key in the differential diagnosis of melasma. Patients with melasma may be diagnosed more accurately using a rapid, label-free, non-invasive microscopy technique. to quantify the melanin and its distribution in the as well as elastosis in melasma. The results suggest potential correlations among the melanin and
A century of nonlinearity in the geosciences 1

11 This paper provides a thumbnail sketch of the evolution of nonlinear ideas in the math- 12 ematics and physics of the geosciences, broadly construed, over the last hundred or so 13 years. It emphasizes the mathematical concepts and methods, and outlines simple ex- 14 amples of how they were, are, and maybe will be applied to the solid Earth — i.e., the 15 crust, mantle, and core — and its ﬂuid envelopes — i.e., the atmosphere and oceans. 16 Plain-Language Summary. Nonlinearity has become a buzzword, along with chaos, 17 complexity, fractals, networks, tipping points, turbulence, and other concepts associated 18 with modern science. We outline here what it all means and how it has aﬀected the progress 19 of the geosciences over the past century, mostly over the last six decades or so. 20
CMAR_A_275307 9929..9939

Department of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; Department of Hepatobiliary, Pancreatic and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Zhejiang, China; Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Navy Medical University), Shanghai, China; Department of Hepatobiliary Surgery, Chongqing University Cancer Hospital, Chongqing, China; Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Hangzhou, China; Department of General Surgery, Ziyang First People’s Hospital, Sichuan, China; Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China; Department of Hepatobiliary, The Third Affiliated Hospital, Chongqing Medical University, Chongqing, China
Bcl-X-L induces Drp1-dependent synapse formation in cultured hippocampal neurons

Maturation of neuronal synapses is thought to involve mitochondria. Bcl-x L protein inhibits mitochondria-mediated apoptosis but may have other functions in healthy adult neurons in which Bcl-x L is abundant. Here, we report that overexpression of Bcl-x L postsyn- aptically increases frequency and amplitude of spontaneous miniature synaptic currents in rat hippocampal neurons in culture. Bcl-x L , overexpressed either pre or postsynaptically, increases syn- apse number, the number and size of synaptic vesicle clusters, and mitochondrial localization to vesicle clusters and synapses, likely accounting for the changes in miniature synaptic currents. Con-versely, knockdown of Bcl-x L or inhibiting it with ABT-737 de- creases these morphological parameters. The mitochondrial ﬁssion protein, dynamin-related protein 1 (Drp1), is a GTPase known to localize to synapses and affect synaptic function and structure. The effects of Bcl-x L appear mediated through Drp1 because overex- pression of Drp1 increases synaptic markers, and overexpression of the dominant-negative dnDrp1-K38A decreases them. Further-more, Bcl-x L coimmunoprecipitates with Drp1 in tissue lysates, and in a recombinant system, Bcl-x L protein stimulates GTPase activity of Drp1. These ﬁndings suggest that Bcl-x L positively regulates Drp1 to alter mitochondrial function in a manner that stimulates synapse formation. localization maturing synapses. of Bcl-x L Enhances Synaptic Activity Hippocam-
Monopoly unions, investment and employment

The optimal wage policy of a monopoly union is time inconsistent, because once installed capital is a quasi-fixed factor and the union can demand higher wages without damaging its employment prospects too much. The consistent outcome is sub-optimal and gives rise to higher wages and lower investment and employment levels. Even when there are no stochastic shocks, the union has an incentive to announce a wage strategy contingent on the capital stock as this serves as a threat and forces the firm to modify its investment behavior. Such an optimal contingent contract is indeterminate, unless adjustment costs are specified to allow for institutional and legal constraints on wage setting. It is inferior to the command optimum, so that it is still time inconsistent. The results are illustrated with a numerical example.
DESIGN A LOW POWER SRAM ARCHITECTURE BASED ON FINFET TECHNOLOGY

- Basically, the average 8T-SRAM does not need any write back scheme. But it has a competitive area. The average 8T SRAM architecture consists of full swing local bit line (BL). This bit line is connected to the gate of read buffer. This read buffer is obtained by boosted word line voltage (WL). The average 8T-SRAM is based on the advanced technology that is 22nm FinFET technology. But in this 22 nm FinFET technology we do not use the word line voltage because it degrades the stability of SRAM. If it degrades the stability then gate of read buffer cannot exerts through the supply voltages then lager delays will occur in the SRAM. To overcome this differential SRAM technology is introduced. In this SRAM proposed architecture, by using cross coupled pMOSs the full swing of local bit lines are exerted and coming to the gate of read buffer, it exerts from a full vdd. This proposed SRAM architectures stores the multiple bits. Now this multiple bits examine from the minimum operating voltage and area per bit. Basically in one block this proposed SRAM stores four bits and obtains minimum voltage of 0.42v. Compared to the average-8T SRAM based on the 22-nm FinFET technology, the proposed SRAM architecture produces time delay less than 62.6.
Aplikasi Transformasi Curvelet untuk Denoising Random Noise : Studi Kasus Data Seismik Sintetik 2D Darat “Antiklin"

Denoising (reduksi noise) merupakan hal umum yang dilakukan pada pengolahan data seismik. Secara umum, kita telah mengenal berbagai filter konvensional seperti bandpass filter dan metode signal enhancemet seperti F-X Deconvolution. Metode tersebut telah lama digunakan dan memiliki kelemahan yakni belum mampu mengembalikan reflektor secara maksimal dengan baik sedangkan noise memiliki nilai frekuensi yang sama dengan nilai sinyal yang baik. Pada penelitian ini, penulis menggunakan data seismik sintetik. Noise yang digunakan adalah gaussian noise karena noise ini merupakan noise yang digunakan secara umum dalam dunia statistik. Setelah ditambahkan noise, maka data sintetik akan diolah menggunakan transformasi curvelet. Hasil dari pengolahan data adalah data seismik sintetik “Antiklin” memiliki nilai signal to noise ratio (SNR) yakni antara 27 hingga 28 dB. Data seismik sintetik ketika diberikan noise memiliki nilai SNR yakni antara 19 hingga 25 dB. Dengan demikian, dapat dikatakan bahwa transformasi curvelet mampu melemahkan dan menghapus random noise. Sementara itu, reflektor pada data masih memiliki bentuk yang hampir sama dengan data forward modelling
INFLUENCE OF CORPORATE SOCIAL RESPONSIBILITY ON CONSUMERS AWARENESS, ATTITUDE, ATTRIBUTION AND PURCHASE DECISION WITH FMCG PRODUCTS

Societal assumptions about CSR have developedamid the recent decades thus have organizations commitments to CSR. These desires on one hand and responsibilities on the other hand, are having now a recognizable impact on the marketplace for goods and services. A study from surveys that many consumers care about the ethical performance of a business. A large proportion of customers say that they care regards manufacturing standards, and there's alternative confirmation that consumers are increasingly keen on CSR and problems with socially capable production, just about characterised as practices of production that respect individuals, communities and the environment. The current study is an endeavour to grasp CSR from consumer Behaviour perspective. This study expects to, measure the knowledge/ awareness level of customers „regarding CSR activities of elite corporations, to know customers „attitude towards getting from corporations that practise CSR, perceive customers' attributions regarding the company‟s motives behind CSR and therefore the impact of CSR on consumers „buying decisions. This analysis can facilitate marketing managers, who are taking under consideration corporate social commitment as a lot of strategic way to profit community furthermore as their business. Firms selected CSR initiatives. CSR firm CSR consumer evaluations. consumers firm firm„s CSR If CSR rather will firm likelihood The time practicing CSR to consumers Proactive CSR help firms get positive evaluations from In reactive CSR doing CSR Reactive CSR firm„s Kamal and Vinnie (2007) in their study seek to explore the factors which influence the consumer attitude and behaviour towards green practices in the lodging industry in India and also the consumers' intentions to pay for these practices. A quantitative and qualitative research methodology using a questionnaire along with secondary research has been proposed. A structured questionnaire has been used using convenience-sampling techniques from National Capital Region in India. Correlation and factor analysis has been used to explore consumers' attitudes and behaviour towards green practices in the lodging industry. The findings reveal that consumers using hotel services are conscious about environmentally friendly practices in India. The consumers would prefer to use lodging that follows these practices but are not willing to pay extra for these services. Indian hotels have the competitive advantage over similar products if they follow green practices. The hotels would have to invest in environmentally friendly practices and look at long-term gains. The authors suggest that government needs to acknowledge and institutionalize the practiseby instituting rewards and offering benefits in taxes
Oral stem cells, decoding and mapping the resident cells populations

ABSTRACT The teeth and their supporting tissues provide an easily accessible source of oral stem cells. These different stem cell populations have been extensively studied for their properties, such as high plasticity and clonogenicity, expressing stem cell markers and potency for multilineage differentiation in vitro. Such cells with stem cell properties have been derived and characterised from the dental pulp tissue, the apical papilla region of roots in development, as well as the supporting tissue of periodontal ligament that anchors the tooth within the alveolar socket and the soft gingival tissue. Studying the dental pulp stem cell populations in a continuously growing mouse incisor model, as a traceable in vivo model, enables the researchers to study the properties, origin and behaviour of mesenchymal stem cells. On the other side, the oral mucosa with its remarkable scarless wound healing phenotype, offers a model to study a well-coordinated system of healing because of coordinated actions between epithelial, mesenchymal and immune cells populations. Although described as homogeneous cell populations following their in vitro expansion, the increasing application of approaches that allow tracing of individual cells over time, along with single-cell RNA-sequencing, reveal that different oral stem cells are indeed diverse populations and there is a highly organised map of cell populations according to their location in resident tissues, elucidating diverse stem cell niches within the oral tissues. This review covers the current knowledge of diverse oral stem cells, focusing on the new approaches in studying these cells. These approaches “decode” and “map” the resident cells populations of diverse oral tissues and contribute to a better understanding of the “stem cells niche architecture and interactions. Considering the high accessibility and simplicity in obtaining these diverse stem cells, the new findings offer potential in development of translational tissue engineering approaches and innovative therapeutic solutions.
Effects of Bisphosphonate on Osteocyte Proliferation and Bone Formation in Patients with Diabetic Osteoporosis

Background Bisphosphonate is currently considered one of the drugs for the first-line treatment of osteoporosis because of its ability to inhibit bone resorption, but the molecular mechanism of its effect on osteocyte proliferation and bone formation of diabetic osteoporosis is still unclear. Objective To confirm the potential effect on of bisphosphonate on osteocyte proliferation and bone formation in patients having diabetic osteoporosis (DO). Methods Sixty DO patients admitted to our hospital from February 2019 to April 2021 were randomly selected and divided into the bisphosphonate group and the control group. The total incidence, incidence of hip fracture, efficacy, bone mineral density, osteocalcin, pain score, osteocyte proliferation, bone formation index, serum calcium, and phosphorus contents were compared between two groups. Results The curative effect of bisphosphonic acid group was better than that of control group, and the difference was statistically significant (P < 0.05). Compared with the control group, the bone mineral density and osteocalcin in the bisphosphonic acid group were significantly improved after treatment, and the pain score in the bisphosphonic acid group was significantly lower than that in the control group (P < 0.05). After intervention treatment, the OD and PINP values in the bisphosphonate group were significantly different from those in the control group (P < 0.05). After treatment, the contents of serum calcium and phosphorus in the bisphosphonic acid group were significantly higher than those in the control group (P < 0.05). The incidence of hip fracture, spinal fracture, and other fractures in the bisphosphonic acid group was significantly lower than that in the control group (P < 0.05). Conclusion The treatment of DO with bisphosphonate is capability of effectively improving bone cell proliferation and bone formation, further alleviating clinical symptoms and promoting the improvement of the disease.