Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of potential miR‑155 target genes in epidermal immune microenvironment of atopic dermatitis patients and their inflammatory effects on HaCaT cells

Atopic dermatitis (AD) is a common inflammatory skin condition and the leading cause of morbidity associated with skin conditions worldwide. For the majority of patients, AD is a lifelong disease that cannot be cured completely. Therefore, in the present study, differentially expressed genes (DEGs) in the epidermal immune microenvironment were screened using bioinformatic techniques. Subsequently, an in vitro cellular model was constructed to investigate the role of microRNA (miR)-155 in immune infiltration during AD. In the present study, two datasets (GSE121212 and GSE157194) were downloaded from Gene Expression Omnibus, before the DEGs were screened and subjected to Gene Ontology and Kyoto Encyclopedia of Genes and Genomes functional enrichment analyses. miRNet was used to predict the possible target genes of miR-155 among the differentially expressed genes found. Consequently, peptidase inhibitor 3 (PI3), FOS-like 1, AP-1 transcription factor subunit (FOSL1), C-X-C motif chemokine ligand (CXCL)1 and CXCL8 were selected to be the potential target genes of miR-155 in the epidermal immune microenvironment of patients with AD. Concurrently, an inflammatory cell model using HaCaT cells was constructed by TNF-α and IFN-γ treatment. The effects of miR-155 on HaCaT cell proliferation and secretion of IL-1β, IL-6, IL-10, IL-15, PI3, FOSL1, CXCL1 and CXCL8 under inflammatory and non-inflammatory conditions were then analyzed. The results showed that after the HaCaT cells were transfected with miR-155, miR-155 inhibited HaCaT cell proliferation and decreased the mRNA expression levels of PI3 and CXCL8, increased the mRNA levels of FOSL1 and secretion levels of IL-1β, IL-6, IL-15 and CXCL1. By contrast, miR-155 decreased the secretion levels of IL-10 and CXCL8. In the inflammatory cell model of HaCaT cells, miR-155 was found to significantly inhibit the proliferation of HaCaT cells during inflammation whilst significantly increasing the secretion of IL-1β, IL-6, IL-10 and IL-15. In addition, miR-155 increased the mRNA expression and secretion levels of CXCL1 and CXCL8, whilst also increasing the mRNA expression levels of PI3. Results from the current study suggest that miR-155 can stimulate keratinocytes to produce inflammatory cytokines and proteins to enhance the inflammatory response in AD.
DualGGAN: A New Facial Style Transfer Network

In response to the background penetration problem of unsupervised style transfer algorithms in most cases, a Transformer style transfer network DualGGAN based on dual generators and fusion of relative position encoding is proposed. The network is trained using the least squares generative adversarial network, and the neural network is used as the image feature extractor to generate feature maps to obtain facial image features with attention weights from the feature maps, utilizing relative position encoding and mask loss to jointly constrain feature region style transfer. The experimental results show that the DualGGAN network effectively reduces artifact generation when implementing facial style transfer, maintains good background consistency, and has good generalization ability. Experiments have shown that the FID and KID indicators on the cat2dog and older2adult datasets are significantly improved compared to other algorithms.
Allogenic Bone Graft in Dentistry: A Review of Current Trends and Developments

In an effort to prepare non-autologous bone graft or biomaterial that would possess characteristics comparable to autologous bone, many different allogenic bone derivatives have been created. Although different existing processing methods aim to achieve the very same results, the specific parameters applied during different stages material preparation can result in significant differences in the material’s mechanical and biological properties The properties, including osteoconductive, osteoinductive, and even osteogenic potential, can differ vastly depending on particular preparation and storage techniques used. Osteogenic properties, which have long been thought to be characteristic to autogenic bone grafts only, now seem to also be achievable in allogenic materials due to the possibility to seed the host’s stem cells on a graft before its implantation. In this article, we aim to review the available literature on allogenic bone and its derivatives as well as the influence of different preparation methods on its performance.
Modélisation numérique de l'évolution des profils de plages sableuses dominées par l'action de la houle

Les barres sableuses pre-littorales ont un role fondamental en morphodynamique des plages soumises a l’action des vagues. Le desequilibre permanent entre les flux sedimentaires induits vers laplage par les non linearites des vagues et ceux induits vers le large par le courant de retour gouverne lamigration transversale des barres. Dans cette these, un nouveau modele morphodynamique de profilde plage integrant l’etat de l’art des processus hydro-sedimentaires a ete developpe. Le faible couten temps de calcul de ce modele permet de realiser des simulations a long terme, O(mois/annees),de la morphologie de plages reelles ayant des caracteristiques variees (pente, type de deferlement,granularite). La simulation sur plusieurs jeux de donnees, de plages reelles et experimentales, a permisd’identifier la contribution respective des principaux processus hydro-sedimentaires dans la dynamiquede la plage suivant les conditions de houle (e.g. Tempete, temps calme). Ces avancees scientifiques ontete integrees a un modele 2DH, ce qui a notamment permis de simuler pour la premiere fois sur des casacademiques la formation d’une barre sableuse rectiligne a partir d’une plage parfaitement plane, suiviedu developpement de corps sableux tridimensionnels. Ces resultats ouvrent la voie vers l’applicationde ce type de modele aux plages naturelles soumises a une large variabilite de regimes de houle.
Neuroablative Intervention for Refractory Obsessive-Compulsive Disorder

Objective This review aims to investigate the progression of neuroablation, along with documented clinical efficacy and safety, in the management of treatment-resistant obsessive-compulsive disorder (OCD). Methods We searched and compiled clinical research results of neuroablation therapy reported to date. We extracted outcomes related to clinical efficacy, side effects, and surgical complications. Additionally, we summarized key claims and findings. Results Neuroablative intervention is a potential treatment approach for refractory OCD. Recent advancements, such as real-time magnetic resonance monitoring and minimally invasive techniques employing ultrasound and laser, offer distinct advantages in terms of safety and comparative efficacy when compared to conventional methods. However, the absence of randomized controlled trials and long-term outcome data underscores the need for cautious consideration when selecting neuroablation. Conclusion Neuroablative intervention shows promise for refractory OCD, but vigilant consideration is essential in both patient selection and surgical method choices due to the potential for rare yet serious complications.
Novel Fluorometric Assay of Antiglycation Activity Based on Methylglyoxal-Induced Protein Carbonylation

Advanced glycation end products (AGEs), which can have multiple structures, are formed at the sites where the carbonyl groups of reducing sugars bind to the free amino groups of proteins through the Maillard reaction. Some AGE structures exhibit fluorescence, and this fluorescence has been used to measure the formation and quantitative changes in carbonylated proteins. Recently, fluorescent AGEs have also been used as an index for the evaluation of compounds that inhibit protein glycation. However, the systems used to generate fluorescent AGEs from the reaction of reducing sugars and proteins used for the evaluation of antiglycation activity have not been determined through appropriate research; thus, problems remain regarding sensitivity, quantification, and precision. In the present study, using methylglyoxal (MGO), a reactive carbonyl compound to induce glycation, a comparative analysis of the mechanisms of formation of fluorescent substances from several types of proteins was conducted. The analysis identified hen egg lysozyme (HEL) as a protein that produces stronger fluorescent AGEs faster in the Maillard reaction with MGO. It was also found that the AGE structure produced in MGO-induced in HEL was argpyrimidine. By optimizing the reaction system, we developed a new evaluation method for compounds with antiglycation activity and established an efficient evaluation method (HEL–MGO assay) with greater sensitivity and accuracy than the conventional method, which requires high concentrations of bovine serum albumin and glucose. Furthermore, when compounds known to inhibit glycation were evaluated using this method, their antiglycation activities were clearly and significantly measured, demonstrating the practicality of this method.
Heat flux estimates across A6 and A7 WOCE sections

One of the main goals of the WOCE programme is to assess meridional heat fluxes across various hydrographic sections in the three oceans. Indeed, except in the North Atlantic Ocean, where numerous convergent estimates exist, the magnitude and sometimes even the sign of oceanic heat fluxes may appear questionable, and the seasonal variability of this heat transport has yet to be documented. Table 1 yields some estimates of meridional heat transports, based on hydrological transects, for the Atlantic Ocean between 30"s and 30"N: heat transport is northward at all latitudes, and seems to increase from 30"s to quantities, i.e. the difference between in-situ values and their vertical average. This method assumes that there is no volume transport across the whole section. that the verticallyaveraged (or barotropic) temperature 6 is constant along the section (equcll to 4.S4"C and 3.23"C respectively for 7.5"N and 4.5"s sections) and that absolute currents are only composed of geostrophic and Ekman currents. Under these conditions, we do not need to determine a reference velocity for geostrophic currents, and the barotropic heat transport becomes:
The New Mitochondrial Genome of Hemiculterella wui (Cypriniformes, Xenocyprididae): Sequence, Structure, and Phylogenetic Analyses

Hemiculterella wui is an endemic small freshwater fish, distributed in the Pearl River system and Qiantang River, China. In this study, we identified and annotated the complete mitochondrial genome sequence of H. wui. The mitochondrial genome was 16,619 bp in length and contained 13 protein coding genes (PCGs), two rRNA genes, 22 tRNA genes, and one control region. The nucleotide composition of the mitochondrial genome was 29.9% A, 25.3% T, 27.4% C, and 17.5% G, respectively. Most PCGs used the ATG start codon, except COI and ATPase 8 started with the GTG start codon. Five PCGs used the TAA termination codon and ATPase 8 ended with the TAG stop codon, and the remaining seven genes used two incomplete stop codons (T and TA). Most of the tRNA genes showed classical cloverleaf secondary structures, except that tRNASer(AGY) lacked the dihydrouracil loop. The average Ka/Ks value of the ATPase 8 gene was the highest, while the average Ka/Ks value of the COI gene was the lowest. Phylogenetic analyses showed that H. wui has a very close relationship with Pseudohemiculter dispar and H. sauvagei. This study will provide a valuable basis for further studies of taxonomy and phylogenetic analyses in H. wui and Xenocyprididae.
Longshore sediment transport : applied wave power approach, field data analysis and evaluation of formulae

The process of sand being moved parallel to the coast by wave and current action is called longshore (sediment) transport. Knowledge oflongshore transport is essential for the design of breakwaters at harbour entrances, for navigation channels and for calculating the amount of dredging they require, for beach improvement schemes and for the determination of the stability of inlets and estuaries. Different aspects oflongshore transport have been investigated, namely, (1) analysis offield data, (2) evaluation oflongshore transport formulae and (3) the development of the wave power approach as an alternative method to calculate longshore transport. In the development of a better understanding oflongshore sediment transport, the following has been done for the first time: (1) a comprehensive data set has been compiled covering almost a full range of conditions occurring on natural beaches; and (2) virtually all longshore transport formulae have been evaluated against this extensive data set. A new improved method, the applied wave power approach, has been developed and extensively calibrated against the same data set. Based on this evaluation, guidelines are now available for design engineers as to which are the best bulk and detailed predictors oflongshore sediment transport. These are respectively, the recalibrated Kamphuis formula and the applied wave power approach. Another useful first, is the derivation of confidence intervals for a longshore transport formula, showing what accuracy can be obtained and that accurate predictions are now possible. In addition, it has now been determined what the minimum required measurement period should be and what the most cost-effective way is for obtaining the true long-term mean net longshore transport rate at a particular site. Stellenbosch University http://scholar.sun.ac.za
Implementation of a Web Camera System in an Australian Neonatal Intensive Care Unit: Pre- and Postevaluation of the Parent and Staff Experience

Background Admission to a neonatal intensive care unit (NICU) for prematurity or illness is necessary for approximately 20% of newborns in Australia, resulting in parent-infant separation. Web cameras in the NICU provide a virtual link for parents to remain remotely connected to their infant during admission. Web camera use is increasing; however, there is limited evidence on the impact of web cameras on parents, infants, and neonatal staff. Objective There were two objectives: (1) to determine the attitudes of parents and staff toward web cameras in the NICU and (2) to compare parental depression, anxiety, and stress levels using validated scales before and after web camera implementation in the NICU. Methods A pre- and postevaluation survey was administered before and after implementation of the NICVIEW camera system in a tertiary NICU in Sydney, Australia. The NICVIEW camera system provides secure real-time viewing of infants and can be accessed from any device with an internet connection. Surveys were administered to parents of inpatients and staff, and included open- and closed-ended questions and Likert scales. Survey questions aimed to determine parent and staff attitudes and use of web cameras before and after implementation. In addition, pre- and postimplementation parental levels of depression, anxiety, and stress, as measured by the 21-item version of the Depression Anxiety Stress Scale (DASS-21) and Parental Stressor Scale: Neonatal Intensive Care Unit, were recorded. Results In total, 94 parents and 109 staff members completed the pre- and postimplementation surveys. Post implementation, 43 of 44 (98%) parents supported web cameras, and 40 of 42 (95%) parents stated that they used web cameras. The most common reasons for support from parents included web cameras making parents feel more at ease, facilitating parent-infant bonding, increasing parental confidence in staff, and allowing others to see infants. There was no significant difference between the parental groups for the depression, anxiety, or stress scales measured by DASS-21. Staff support for web cameras increased significantly from 34 of 42 (81%) participants before to 64 of 67 (96%) participants after implementation (P=.01). Following implementation, there was a resolution in staff concerns about web cameras having an adverse impact on staff roles and privacy and security concerns. Conclusions Web camera use in a tertiary Australian NICU was strongly supported by parents and staff and may reduce parental stress, facilitate parent-infant bonding, and encourage positive parent-staff engagement. Web cameras are a feasible method of providing continuity of care for families and should be considered as a standard of care in similarly resourced settings.
Muscle fatigue, bioenergetic responses and metabolic economy during load‐ and velocity‐based maximal dynamic contractions in young and older adults

We evaluated whether task‐dependent, age‐related differences in muscle fatigue (contraction‐induced decline in normalized power) develop from differences in bioenergetics or metabolic economy (ME; mass‐normalized work/mM ATP). We used magnetic resonance spectroscopy to quantify intracellular metabolites in vastus lateralis muscle of 10 young and 10 older adults during two maximal‐effort, 4‐min isotonic (20% maximal torque) and isokinetic (120°s−1) contraction protocols. Fatigue, inorganic phosphate (Pi), and pH (p ≥ 0.213) differed by age during isotonic contractions. However, older had less fatigue (p ≤ 0.011) and metabolic perturbation (lower [Pi], greater pH; p ≤ 0.031) than young during isokinetic contractions. ME was lower in older than young during isotonic contractions (p ≤ 0.003), but not associated with fatigue in either protocol or group. Rather, fatigue during both tasks was linearly related to changes in [H+], in both groups. The slope of fatigue versus [H+] was 50% lower in older than young during isokinetic contractions (p ≤ 0.023), consistent with less fatigue in older during this protocol. Overall, regardless of age or task type, acidosis, but not ME, was the primary mechanism for fatigue in vivo. The source of the age‐related differences in contraction‐induced acidosis in vivo remains to be determined, as does the apparent task‐dependent difference in the sensitivity of muscle to [H+].
Carbon efficient production of chemicals with yeasts

Microbial metabolism offers a wide variety of opportunities to produce chemicals from renewable resources. Employing such processes of industrial biotechnology provides valuable means to fight climate change by replacing fossil feedstocks by renewable substrate to reduce or even revert carbon emission. Several yeast species are well suited chassis organisms for this purpose, illustrated by the fact that the still largest microbial production of a chemical, namely bioethanol is based on yeast. Although production of ethanol and some other chemicals is highly efficient, this is not the case for many desired bulk chemicals. One reason for low efficiency is carbon loss, which decreases the product yield and increases the share of total production costs that is taken by substrate costs. Here we discuss the causes for carbon loss in metabolic processes, approaches to avoid carbon loss, as well as opportunities to incorporate carbon from CO2, based on the electron balance of pathways. These aspects of carbon efficiency are illustrated for the production of succinic acid from a diversity of substrates using different pathways.
Deep Learning-Based Identification Algorithm for Transitions Between Walking Environments Using Electromyography Signals Only

Although studies on terrain identification algorithms to control walking assistive devices have been conducted using sensor fusion, studies on transition classification using only electromyography (EMG) signals have yet to be conducted. Therefore, this study was to suggest an identification algorithm for transitions between walking environments based on the entire EMG signals of selected lower extremity muscles using a deep learning approach. The muscle activations of the rectus femoris, vastus medialis and lateralis, semitendinosus, biceps femoris, tibialis anterior, soleus, medial and lateral gastrocnemius, flexor hallucis longus, and extensor digitorum longus of 27 subjects were measured while walking on flat ground, upstairs, downstairs, uphill, and downhill and transitioning between these walking surfaces. An artificial neural network (ANN) was used to construct the model, taking the entire EMG profile during the stance phase as input, to identify transitions between walking environments. The results show that transitioning between walking environments, including continuously walking on a current terrain, was successfully classified with high accuracy of 95.4 % when using all muscle activations. When using a combination of muscle activations of the knee extensor, ankle extensor, and metatarsophalangeal flexor group as classifying parameters, the classification accuracy was 90.9 %. In conclusion, transitioning between gait environments could be identified with high accuracy with the ANN model using only EMG signals measured during the stance phase.
Aripiprazole 2-month ready-to-use 960 mg (Ari 2MRTU): review of its possible role in schizophrenia therapy

Abstract Most patients with schizophrenia need life-long treatment. There is therefore a continued need for effective and tolerable treatment options. A 2-monthly LAI formulation of aripiprazole, Aripiprazole 2-Month Ready-to-Use 960 mg (Ari 2MRTU 960) has recently been approved in the US. Here, the possible role in therapy for this new treatment option is discussed in a narrative review. PubMed was searched for literature on long-acting injectables with a focus on patient-reported outcomes and real-world evidence on extended injection intervals (2–3 months). Dopamine D2 partial agonists, one of which is aripiprazole, exhibit favorable tolerability and safety properties. Additionally, there are many advantages in using long-acting injectable formulations such as enhanced treatment persistence and stability of patients as well as reduced rates of relapses, hospitalizations, and death. Some of these advantages become more pronounced with longer injection intervals. Additional advantages of longer injection intervals are more room for non-medication-related communication between healthcare professionals and patients, patient and physician preferences, reduced caregiver burden, and easier transitioning from inpatient to outpatient treatment. Taken together, since aripiprazole may be a good treatment choice for many patients based on its favorable safety and tolerability profile, and given the advantages of LAI treatment over oral treatment and the advantages of reduced dosing frequency, Ari 2MRTU 960 may become an important treatment option for many clinically stable patients with schizophrenia.
Source parameters of seismic events at Heinrich Robert mine, Ruhr Basin, Federal Republic of Germany: Evidence for nondouble-couple events

Abstract A three-component digital seismic station is in operation at Heinrich Robert coal mine in the Ruhr basin, at a depth of 890 m. A cluster of seismic events occurred at the beginning of 1987 at a distance of about 5 km from the station and continued in 1988. Source parameters of 46 tremors selected from the cluster, with local magnitude from 1.2 to 2.3, are studied. The ratio of P -wave to S -wave corner frequency is variable, implying its dependence on the angle of observation and in turn the variability of focal mechanism with time. The scaling relations indicate that characteristic tremors, with a fault length of about 200 m, are possibly generated in the area, but the evidence is not conclusive. The seismic energy for a given seismic moment can vary by a factor of 20, and the ratio of S -wave to P -wave energy ranges from 1.5 to 30. Stress release estimates show low values, not exceeding a few bars, typical for tremors induced by mining. A comparison of the apparent stress with the static stress drop divides the selected tremors into high and low apparent stress events. The latter events are characterized by high P -wave energy and almost constant and large ratio of P -wave to S -wave corner frequency, which differs from the lower ratios of other events, implying similar focal mechanism. These high P -wave energy tremors are the most likely candidates for nondouble-couple events.