Miracle-dz/UniFAR-FTUs huggingface dataset:
Efecto del julocrotol, isojulocrotol y julocrotona sobre la producción de especies reactivas de oxígeno en leucocitos humanos estimulados con acetato de forbol miristato

Se evaluo el efecto antiinflamatorio y antioxidante de los alcaloides glutarimidicos: julocrotol, isojulocrotol y julocrotonaaislados de la especie Croton cuneatus. los compuestos no indujeron muerte celular en cultivos primarios de leucocitoshumanos cuando la viabilidad fue evaluada por el metodo del bromuro de 3-(4,5-dimetiltiazol-2-il)- 2,5- difenil tetrazolio(Mtt). todos los compuestos disminuyeron la produccion del anion superoxido (o2·–) en leucocitos humanos activadospor el acetato de forbol miristato (PMa) en una forma dependiente de la dosis, cuando este fue evaluado a traves de lareduccion del nitro azul de tetrazolio (nbt). la julocrotona fue el compuesto mas potente inhibiendo la produccion delo2·– con una Ci50 de 10,21 mM, mientras que el julocrotol y el isojulocrotol presentaron valores de Ci50 de 16,19 y 25,13mM, respectivamente. los tres alcaloides glutarimidicos fueron mas potentes que la talidomida (analogo estructural). ninguno de los alcaloides exhibio efecto antioxidante en el metodo del 1,1-difenil-2-picrilhidrazil (dPPh). se concluye quejulocrotol, isojulocrotol, y julocrotona, exhiben un potente efecto antiinflamatorio por lo que pueden ser consideradoscompuestos guias para el desarrollo de nuevas terapias.
Evolving Activism in an Anti-Immigrant Administration: Asian American, Native Hawaiian, and Pacific Islander Nonprofit Experiences after the 2016 Elections

ABSTRACT Asian American, Native Hawaiian, and Pacific Islander (AANHPI)-serving nonprofits were at the forefront of pro-immigrant advocacy during the Trump Administration in the midst of sudden changes in policy that caused extreme turmoil for AANHPIs. This study examines how these federal sociopolitical factors shaped nonprofit activism and finances for Los Angeles AANHPI organizations in 2017. Using interviews, I found that nonprofits could innovate in small ways to support AANHPIs, but were also limited in their advocacy because of funding and political constraints. These findings demonstrate the challenges and persistence required for AANHPI activism in a xenophobic and restrictive landscape.
Strategies for Effective Waste Reduction and Management of Building Construction Projects in Highly Urbanized Cities—A Case Study of Hong Kong

Hong Kong is a densely populated city with high-rise developments, and as in other metropolitan cities, the amount of waste generated from construction projects in the city is increasing annually. The capacity of existing landfills is expected to be saturated by the 2020s. Construction waste management has been implemented for years but the performance is still not satisfactory. The aim of this research paper is to explore and formulate strategies and measures for effective construction waste management and reduction in highly urbanized cities such as Hong Kong. A desktop study on construction waste management practices was carried out for a preliminary understanding of the current situation in Hong Kong. Semistructured interviews and focus group meetings were further conducted to shed light on how to improve construction waste reduction and management in Hong Kong. The main contributions of this research study are the potential short-term, medium-term, and long-term strategies, which are related to the design stage, tender stage, construction stage, and government support. The five major strategies recommended are financial benefits to stakeholders, public policies in facilitating waste sorting, government supports for the green building industry, development of a mature recycling market, and education and research in construction waste minimization and management.
Does it help to see the speaker’s lip movements?

Simultaneous interpreting combines auditory and visual information. Within a multitude of visual inputs that interpreters receive, the one from the speaker seems to be particularly important (Bühler 1985; Seubert 2019). One reason might be that lip movements enhance speech perception and might thus reduce cognitive load in simultaneous interpreting and hence, induce lower mental effort. This effect may be even more pronounced when noise is added to the source speech. This study was conducted to investigate cognitive load and mental effort during simultaneous interpreting (a) with and without the ability to see speaker’s lip movements, and (b) with and without interfering noise. A group of listeners was included to control for task-related effects. Mental effort and cognitive load were measured using pupillometry, interpreting accuracy measures, and subjective reports. The facilitation hypothesis for lip movements was not confirmed. However, the pupillometric data suggests that lip movements may increase arousal.
Extraocular muscle diameter in Makurdi, North Central Nigeria: what is normal?

Background: Establishing normal values of extra ocular muscle (EOM) diameter is essential in a given population. Factors including race, region, gender and environment affect the normal diameter of the EOM. The aim of the study was to determine the normal sizes of the EOM in a population in the North Central part of Nigeria using computed tomography (CT). Methods: One hundred and eighty-three CT images of patients who underwent craniofacial imaging for other conditions and who met the inclusion criteria were evaluated. The maximum diameters of the EOMs on coronal reformatted CT images which are the superior group (SG) (superior rectus and the levator palpebral), inferior rectus (IR) medial rectus (MR) and lateral rectus (LR) were assessed. Results: The mean values±SD obtained were 3.65±1.13, 3.93±0.94, 3.40±0.67, 3.43±0.92 for SG, 1R, MR, and LR muscles respectively on the right and 3.61±1.07, 3.86±0.92, 3.34±0.70, 3.42±0.08 for SG, IR MR and LR muscles respectively on the left. The order IR>SR>MR>LR of average muscle diameter was obtained. The females in this region showed slightly higher mean values of the diameter of the EOM than the males; however, this was not statistically significant. By age, there was no consistent correlation. Conclusions: The established normal values of the EOM may serve as a reference point for ophthalmologist and for cosmetic surgeons and also will add to the pool of the existing knowledge for academic purposes.
An AAC tablet application for children with language impairment

People with communication impairment need an alternative communication channel to complete daily activities. Augmentative and alternative communication (AAC) systems can help provide a communication medium to support such users. The involvement of speech and language pathologists (SLPs) who work in rehabilitation centers can help develop better solutions. This paper presents the development of an AAC tablet application that uses pictures on the screen and voice feedback to help children with language impairment improve the efficiency in their communication. The proposed solution maps the sentences commonly used by children into appealing symbols. The children can use these symbols instead of constructing sentences from scratch, as done by most of the previously proposed solutions in the literature. The application was evaluated by SLPs on six children with language impairment. This research presents a design methodology when providing such a solution for touch screen devices for people with language impairment. A set of accessibility guidelines is proposed for AAC computer-based solutions, which can help researchers and practitioners. The obtained results prove that the proposed system improves the children’s stimulation to communicate and decreases communication time. Such a solution can assist therapists as a resource to improve their patients’ communication.
Electrical Characteristics of Postoxidation Annealed Very Thin SiO2 Films Potential Benefits of Rapid Thermal Processing

Ten nanometers of oxides grown in a conventional diffusion furnace have been annealed at 1050°C in the same diffusion furnace and in a rapid thermal reactor. Their interfacial electrical properties (V FB and D it at midgap) have been determined, and their breakdown quality has been assessed by means of both time zero and time-dependent dielectric breakdown (TZDB, TDDB) experiments. We observed overall improvement of the annealed samples over the control ones that can be explained by the stress relaxation the anneal step provided. In spite of its much shorter duration, however, the rapid thermal anneal (RTA) outperformed the furnace anneal, thus indicating that the improvement is beyond a conventional viscoelastic stress relaxation. In fact the samples that underwent the RTA process exhibited a distinct electron trapping reduction that may explain their better performance. The contradictory results recorded during this investigation between TZDB and TDDB measurements have been shown to arise from the different trapping behavior of the different samples considered.
Co-primary endpoint of overall survival for tebentafusp (tebe)-induced rash in a phase 3 randomized trial comparing tebe versus investigator’s choice (IC) in first-line metastatic uveal melanoma.

9527 Background: Tebe is a bispecific consisting of an affinity-enhanced T cell receptor fused to an anti-CD3 effector that can redirect T cells to target gp100+ cells. In this Phase (Ph) 3, randomized trial of first line (1L) metastatic uveal melanoma (mUM) [NCT03070392], tebe significantly improved overall survival (OS) vs. investigator’s choice (IC) in the intention-to-treat population (ITT). In previous trials, tebe-related skin adverse events (AEs), hypothesized to be on-target, off-tumor activity against gp100-expressing melanocytes, were associated with improved OS. This association was tested prospectively as a co-primary endpoint in the Ph3 study. Methods: 378 1L HLA-A*02:01+ mUM pts were randomized 2:1 to tebe (n = 252) or IC (n = 126). Co-primary endpoints were 1) OS in all randomized pts (ITT) and 2) OS in tebe-randomized pts who develop any grade rash in week (wk) 1 vs. all receiving IC. Rash was defined as composite of preferred AE terms. Melanocyte-related AEs (MRAEs) were defined as pigment change AEs in the skin or hair. Overall study-wide alpha was controlled at 0.05, with 90% assigned to ITT and 10% to rash. This analysis was conducted on the first interim analysis (data extracted Nov-2020). Results: In the 245 tebe treated pts, the characteristic skin related AEs included most frequently rash (at any time) in 201 pts (82%), pruritis in 167 pts (68%), MRAEs in 109 pts (45%) and erythema in 69 pts (28%). While rash, erythema and pruritis mostly occurred in the first 4 weeks, MRAEs occurred after a median of 2.7 mo. Rash captures most pts, 201/227 (89%), who have any of these skin related AEs. Rash occurred in 146 pts (60%) by wk 1; 179 pts (73%) by wk 2; and 195 pts (80%) by wk 3. Tebe pts with wk 1 rash had significantly longer OS vs. the IC arm, HR 0.35 (95% CI 0.23, 0.53), p < 0.0001. The estimated 1-yr OS rates were 83% vs 58%, respectively. When expanded to include tebe pts with rash through wk 3, the 1-yr OS rate of 75% was still numerically higher than IC. The 50 (20%) tebe pts who did not experience rash by week 3 had 1-yr OS rate of 55%. Conclusions: In 1L mUM pts, tebe significantly improved OS compared to IC in the ITT analysis. Week 1 rash, presumed due to tebe redirection of T cells to gp100+ skin melanocytes, was associated with a very strong OS benefit. Therefore, rash may be a marker that the immune system can be mobilized by tebe to target gp100+ cells. The vast majority of tebe pts will develop a rash at some point, and tebe pts without rash may still derive benefit. Clinical trial information: NCT03070392.
Analysing the influence of industrial waste fillers on the ageing susceptibility of asphalt concrete

ABSTRACT The ageing of asphalt mixes catalyses the occurrence of several pavement distresses. This study assessed the influence of the nature and quantity of the filler on the ageing susceptibility of asphalt concrete. The designed asphalt mixes containing control filler (stone dust) and four industrial wastes (copper tailing, glass powder, Kota stone dust, and red mud) were added in different amounts (4, 5.5, 7, and 8.5%). The ageing susceptibility of asphalt mixes was analysed by comparing the performance of un-aged and long-term aged asphalt mixes in terms of Marshall stability (MS), tensile strength ratio (TSR), indirect tensile strength (ITS), Marshall quotient (MQ), and Cantabro loss (CL) using ageing indices. The statistical analysis of the results was performed using multiple two-way ANOVA tests. The analysis inferred that the nature of filler and their amount in asphalt mixes had a statistically significant effect on their ageing susceptibility as observed from the changes in their TSR, CL, MQ, and MS. However, ageing susceptibility of asphalt mixes corresponding to their ITS values seemed to be significantly influenced only by the amount of the filler. The ageing susceptibility of asphalt concrete mixes is found to be greatly influenced by their apparent film thicknesses.
Multilingual policies as dystopia: From less to more desirable futures in education

In ‘Literature and Life’, Deleuze remarks that all literature manifests as delirium, and, as such, the destiny of literature is to play itself out between two poles that create and reflect life back to itself: what the human desires, and the constant changes life imposes onto us. Taking Deleuze’s statement as a point of departure concerning the power of social fiction, this article mobilizes the dystopian imagination as a tool to evaluate what language policies do as they channel human desire to shape linguistic practices. Specifically, this article explores the extent to which the literary dystopian lens can help us plot more desirable futures for multilingualism in education. Through a critical fabulation about India’s three-language policy’s effects in schools, we bear witness to this language policy’s disciplinarian action, which reinforces linguistic hierarchies and territorial disputes present in this nation’s history. Indeed, decisions on policies meant to assist linguistically minoritized students have often rested on complicated assumptions about what language means. These assumptions operate under liberal and neoliberal ideologies that commodify and narrow citizens’ linguistic choices, thereby framing one’s authority over language as something that exists outside the human mind. By approaching India’s three-language policy as a futuristically fabulated case study, we reflect on the potentiality of dystopian narratives to function as an analytical method and a critical lens to anticipate ethical problems in language policies’ design.
THE CHALLENGES, RISKS AND PROSPECTS OF THE REALISATION OF THE MUSIC METHODOLOGY MODULE OF ONE – YEAR EDUCATION PROGRAMME

The reform of teachers’ education commenced by the Ministry of Education and Science provides an opportunity to obtain a qualification as a teacher within one year, encompassing studies based in a working environment for those who already have higher education. The goal of the research is to identify the challenges, risks and perspectives of the realization of the module “Music methodology” of the study course “Integrated methods in Teaching Culture Understanding and Self-expression in Art” within the one-year study programme “Skolotājs”. The research compared study course plans in music teaching and choir work methodology at two Latvian higher education institutions, as well as at two foreign higher education institution, where a qualification as a music teacher at a comprehensive school can be attained. The research was undertaken based on an analysis of theoretical sources, providing an understanding about a synthesis of varying contemporary methodological approaches. It encompasses the acquisition of a knowledge of cultural history and the history of music, the style and future directions of popular music, desirably not just theoretically but practically as well, in the education of the students. The actualization of such study courses as music teaching methodology, the research process in music teaching, music history and stylistics, the psychology of music, conducting, choir/vocal ensemble work, methodology and music project management are important for the high quality and integrated acquisition of music teaching methodology.
The status of striped bass,
 
 Morone saxatilis
 ,
 
 as a commercially ready species for U.S. marine aquaculture

Striped bass, Morone saxatilis , is an anadromous fish native to the North American Atlantic Coast and is well recognized as one of the most important and highly regarded recreational fisheries in the United States. Decades of research have been conducted on striped bass and its hybrid (striped bass (cid:1) white bass Morone chrysops ) and culture methods have been established, particularly for the hybrid striped bass, the fourth largest finfish aquaculture industry in the United States (US $50 million). Domesticated striped bass have been developed since the 1990s and broodstock are available from the government for commercial fry production using novel hormone-free methods along with traditional hormone-induced tank and strip spawning. No commercial-scale intensive larval rearing technologies have been developed at present and current fingerling production is conducted in fertilized freshwater ponds. Larval valued at about US $8.45 to US $9.25 per kg whole; the farm gate value for cultured striped bass may be as much as US $10.00 or more per kg depending on demand and market. The ideal market size is between 1.36 and 2.72 kg/fish, which is considerably larger than the traditional 0.68 to 0.90 kg/fish for the hybrid striped bass market. 0.57 0.91 US or US for 2.5 lb or fish). Recent for striped bass in in ranged from US $26.45 to US $41.89 per kg (US $12.00 – US $19.00 per lb) for boneless, skin-on fillets of wild caught striped bass. Market surveys conducted with Locals Seafood in North Carolina found that marketing value-added, boneless, skin-on fillets of aquacultured striped bass in the mid-Atlantic region is feasible even with a final product price of US $39.68 per kg (US $18.00 per lb). Based on these survey data, we estimate the U.S. farm gate value for striped bass can be as low as US $10.14 per kg (US $4.60 per lb) and as high as US $13.23 per kg (US $6.00 per lb) based on a 50.0% to 70.0% mark-up margin. Furthermore, assessments have shown consumer willingness to pay premium prices for striped bass (Quagrainie, 2019). These data show a clear economic and market potential for aquaculture production of striped bass, which already has a wide consumer acceptance and appeal.
Synthesis and Characterization of Some New Coumarin Derivatives as Probable Breast Anticancer MCF-7 Drugs

This study aimed to synthesize quinolinone derivatives and investigate their cytotoxic activity. The compound 1-azacoumarin-3-carboxylic acid (2-oxo-1H-quinoline-3-carboxylic acid) was obtained via the cyclocondensation of 2-hydroxybenzaldehyde with diethyl malonate in base catalyst to give ethyl coumarin-3-carboxylate, followed by the ammonolysis of ester (ethyl coumarin-3-carboxylate) with ammonia in the presence of anhydrous potassium carbonate. Treatment of 2-oxo-1H-quinoline-3-carboxylic acid with acetic anhydride, cinnamaldehyde, cinnamic acid and methyl 5-phenyl-2-cyano-2,4-pentadienoate under different conditions led to the formation of 1 (substituted) aza coumarin-3-carboxylic acids (1-N-(acetyl)-azacoumarin-3-carboxylic acid, 1-N-(2-Formyl-1-phenyl) vinyl-azacoumarin-3-carboxylic acids, 1-N-[2-(Hydroxy) carbonyl-1-(Phenyl) vinyl]-azacoumarin-3-carboxylic acid and 1-N-(4-Cyano-5-methoxy-5-oxo-1-Phenylpenta-1,3-diene-1-y)-azacoumarin-3-carboxylic 284 acid), respectively. The structures of synthesized 1-(substituted) azacoumarin-3-carboxylic acids were confirmed based on spectroscopic methods (IR and NMR), along with elemental analyses. Interestingly compound 6 demonstrated probable impacts as an anti-cancer drug against the MCF-7 cell line. The mechanism of action was assessed using a flow cytometric assay. The outcomes revealed that compound 6 could arrest the cell cycle at G2/M phase and pre-G1 apoptosis.
Parental mediation and rules for children’s digital technology use during spring 2020 lockdown in Croatia

The pandemic of the COVID-19 virus brought out many changes in family routines across the world. This research aims to investigate changes in rules for children’s digital technology (DT) use and parental mediation during the first lockdown due to the COVID-19 pandemic in Croatia. Participants are 281 parents of children aged 3 to 14 years who completed an online survey containing questions about possible changes in the application of different rules regarding DT use and possible changes in different mediation behaviors regarding DT use during the lockdown in March 2020 due to the COVID-19 pandemic in Croatia. Results are analyzed separately for kindergarten children and children attending primary school. Results show a trend implying that during the first lockdown in 2020 most families didn't introduce new rules or abandon them compared to the time before lockdown, but those that did point to parents allowing their children a little more freedom regarding DT, especially for school-aged children. Additionally, small changes compared to the time before lockdown are observed in parental mediation behavior, and these are most evident concerning activities aiming to enable more independent use of DT and safe (probably also more independent) use of DT among school-aged children.
Key performance‐cost tradeoffs in smart electric vehicle charging with distributed generation

European Commission Horizon 2020, Grant/Award Number: 734325; Engineering and Physical Sciences Research Council, Grant/Award Number: EP/ P005950/1; Engineering and Physical Sciences Research Council United Kingdom Abstract Growing penetration of Electric Vehicles (EV) and Distributed Generation (DG) is driving sharper peaks in demand and supply, which, if poorly managed, manifest as over‐ or undervoltage and disrupt grid service quality. Smart charging schemes reschedule EV charging load according to factors such as grid stability, price signals, etc. It remains unclear how to do this while meeting the diverging needs and expectations of multiple concerned participants. This paper proposes two smart charging schemes for secondary voltage control in the distribution network and analyses performance‐cost tradeoffs relating to key players in the Smart Grid. To support these schemes, a distributed communications architecture is designed that jointly minimises traffic burden, computation load and investment in Information and Communications Technology (ICT) hardware. Scheme I (Smart Curtailment), curtails load and DG for peak shaving. Scheme II (Smart Correction) optimises cost‐efficiency for subscribing users by maximising power transfer during off‐peak hours or when renewable energy is high. Performance of both schemes is consolidated statistically under almost 6 months of practical input profiles. Dramatic improvements in EV & DG capacity are demonstrated and key performance‐cost tradeoffs relating to Voltage Control, Peak Shaving, User Inconvenience, CO2 Emissions and ICT Deployment Cost are identified.