Miracle-dz/UniFAR-FTUs huggingface dataset:
Identity Construction of Pakistani Female Entrepreneurs in Religious Framework: An Interplay of Sociocultural and Religious Factors

This article focuses on the identity construction of Pakistani female entrepreneurs as an interplay of religion, culture and entrepreneurial context. We contribute to theory development on how in a Pakistani context the Islamic values and Pakistani cultural values shape the entrepreneurial identity of the women entrepreneurs through an intersectional analysis. We draw on five in-depth interviews of women entrepreneurs to illustrate how the women entrepreneurs execute their ventures and carry their entrepreneurial identity while carrying a blend of Islamic values and Pakistani cultural values. Pakistani women entrepreneurs employ the Islamic norms and values that are particularly practised by the family as a boundary, however, the cultural norms sometimes overweight the Islamic values in construction of identity. There is an evidence for negotiating process that acts as an enabler to make space for individualism, honour and entrepreneurship. In order to resist the rigid cultural interpretation of behavioural norms, various cultural, religious and familial identities are crafted to expand the boundaries of what is allowed. This enables them to bank on the Islamic values that enable them to be economically active without violating religious boundaries. Our study contributes to studies on entrepreneurship by showing how these female entrepreneurs gain agency at the crossroads of gender country context and religion.
Silencing of AJAP1 expression by promoter methylation activates the Wnt/β-catenin signaling pathway to promote tumor proliferation and metastasis in salivary adenoid cystic carcinoma

Background Salivary adenoid cystic carcinoma (SACC) is a unique malignant tumor of the salivary gland with poor prognosis, which is not effective with chemotherapy and targeted drugs. Therefore, it is important to explore the molecular mechanism underlying SACC invasion and metastasis to develop novel therapeutic strategies and targets in clinical research. Methods Real-time quantitative polymerase chain reaction (RT-qPCR) and western blot (WB) were performed to detect the expression of Adherens Junctions Associated Protein 1 (AJAP1). Methylation-specific PCR was used to evaluate the methylation of the AJAP1 promoter. AJAP1 was overexpressed or knocked down by lentivirus-mediated transfection. Kaplan-Meier analysis was conducted to create a survival curve and the log-rank test was used to analyze the overall survival (OS). The prognostic correlation was assessed using univariate and multivariate Cox regression analyses. Co-immunoprecipitation (Co-IP) was utilized to pull down the possible binding protein of AJAP1 and laser scanning confocal microscopy was applied to detect the subcellular localization of AJAP1, E-cadherin, and β-catenin. Cell viability, colony formation, wound healing, and Transwell invasion assays were performed to evaluate the function of AJAP1 in vitro. A subcutaneous xenograft assay in nude mice was performed to verify the function of AJAP1 in vivo. Results AJAP1 was downregulated in SACC tumors and was closely related to SACC lymph node/distant metastasis, which was an independent risk factor for SACC prognosis. Methylation-specific PCR confirmed that high methylation of the AJAP1 promoter was the main cause of its silencing. Overexpression or knockdown of AJAP1 in SACC cells could significantly inhibit or promote the proliferation, invasion, and metastasis of SACC cells, respectively, in both the in vitro and in vivo experiments. Mechanically, we found that AJAP1 binds to E-cadherin and β-catenin to form a complex in cytomembrane, reducing the nuclear translocation of β-catenin and blocking the Wingless/Integrated/β-catenin (Wnt/β-catenin) signaling pathway to play a suppressive role in cancer. Conclusions In conclusion, these results suggest that the downregulation of AJAP1 protein expression may play a certain role in progression and metastasis of SACC. Our study indicates that AJAP1 may be a potential prognostic molecular marker and therapeutic target for SACC.
Position Control of Parabolic Dish Antenna Using Feedback, Zeigler-Nichols and Quadratic Optimal Regulator Methods

A unity feedback servomotor actuated parabolic dish antenna system was modeled, and two different types of controllers were designed for the system using; Ziegler-Nichols and Quadratic Optimal Regulator methods for the close loop operation of the system. Their responses were simulated using the software package MATLAB 7.1. Simulation results showed that each of the controllers greatly improved the system response. Best system responses were obtained via the Quadratic Optimal Regulator method. Controllers were presented and applied to the system. The controllers designed have been simulated and observed to have good performance, where the results show that the rise time, peak time, maximum overshoot and settling times are; 0.7900 second, 1.1450 seconds, 14.77% and 2.4900 seconds respectively for the unity feedback system. With the ZN controller the results are; 0.2550 seconds, 0.4100 seconds, 18.88% and 1.9300 seconds that using the QO controller are 0.6150 seconds, 0.8050 seconds, 4.27% and 1.0650 seconds, which shows that the response had improved drastically with the controllers. And the results have shown that the QO controller gives the best response. Hence, a position controller has been designed successfully for closed loop operation of the system and it runs faster and very close to the reference position.
Robust Adaptive Neural Network Control For A Class Of Multiple‐Input Multiple‐Output Nonlinear Time Delay System With Hysteresis Inputs And Dynamic Uncertainties

This paper studies an adaptive neural control for nonlinear multiple‐input multiple‐output systems with dynamic uncertainties, hysteresis input, and time delay. The studied systems are composed of N nonlinear time‐delay subsystems and the interconnection terms are contained in every equation of each subsystem. Adaptive neural control algorithms are developed by introducing a well‐defined smooth function. The unknown time‐varying delays and the unmodeled dynamics are dealt with by constructing appropriate Lyapunov–Krasovskii functions and introducing an available dynamic signal. The main advantage of the proposed controllers is that they contain fewer parameter estimates that need to be updated online. Consequently, the accuracy of ultimate tracking errors asymptotically approaches a pre‐defined bound, and all signals in the closed‐loop systems are also ensured to be uniformly ultimately bounded. Finally, a simulation example is provided to illustrate the effectiveness and merits of the proposed adaptive neural network control schemes.
Trastornos mentales en el sistema penitenciario: una perspectiva desde el Comité Técnico de las prisiones de Tamaulipas, México

La prevalencia de trastornos mentales en las prisiones es un fenómeno en aumento en el que se encuentran involucrados diversos actores sociales, la salud de las personas privadas de la libertad y el funcionamiento de las instituciones penitenciarias. El presente estudio tiene como objetivo describir los desafíos y estrategias implementadas por los miembros de los Comités Técnicos (CT) para atender, evaluar y dar seguimiento al tratamiento penitenciario de las personas privadas de la libertad con trastornos mentales en los CEDES del estado de Tamaulipas. A través de entrevistas semiestructuradas aplicadas al personal de los Comités Técnicos de centros penitenciarios del estado, se encontró que uno de los principales obstáculos para la atención de este grupo social es la falta de psiquiatras, así como de personal especializado para su atención; por lo que el personal desarrolla diversas estrategias para cumplir con los requerimientos de este grupo social tanto en terapia ocupacional, cuidados primarios y farmacoterapia.
Aspects of quadratic optimization - nonconvexity, uncertainty, and applications

Quadratic Optimization (QO) has been studied extensively in the literature due to its application in real-life problems. This thesis deals with two complicated aspects of QO problems, namely nonconvexity and uncertainty. A nonconvex QO problem is intractable in general. The first part of this thesis presents methods to approximate a nonconvex QP problem. Another important aspect of a QO problem is taking into account uncertainties in the parameters since they are mostly approximated/estimated from data. The second part of the thesis contains analyses of two methods that deal with uncertainties in a convex QO problem, namely Static and Adjustable Robust Optimization problems. To test the methods proposed in this thesis, the following three real-life applications have been considered: pooling problem, portfolio problem, and norm approximation problem.
Automated In-Situ Monitoring for Variability-Resilient and Energy-Efficient Digital Circuits Demonstrated on a Viterbi Decoder in 22-nm CMOS

The impact of variability in CMOS technology increases with scaling and low-voltage operation, where conventional design flows need to manage large design margins to ensure an acceptable yield. In this article, we present a novel methodology to improve the digital circuit’s energy efficiency binomial eliminating the unnecessary margins and guaranteeing the same $4\sigma $ production yield. The proposed methodology is based on an automated in situ error prediction strategy fully compatible with a conventional industrial design flow. The main field of application is the design of generic DSP blocks. As such, the methodology is demonstrated on a 22-nm CMOS Viterbi decoder. Results show that with this methodology, we can safely recover more than 95% of the conventional energy design margin, improving the energy efficiency by 30%–40% with a low area overhead of 6%. Fabricated and tested circuits operate with a maximum of 16 mV voltage margin, providing an additional maximum energy benefit of 55% compared to a replica-based adaptive voltage scaling (AVS) system.
Depth estimation based on binocular disparity and color-coded aperture fusion

In this paper we present a novel binocular passive depth sensor with minor hardware modifications on color-coded aperture. It is based on binocular disparity and color-coded aperture depth from defocus fusion algorithm. The sensor measure depth in detail on occlusion and blur condition in contrast to prior-art approaches. Contributions of this paper are: (1) introduction of color-coded aperture binocular designs, (2) corresponding fusion algorithm. The red and green optical filters are placed in the front of iris of the left and right cameras respectively. In order to correct the fuzzy kernel, we use the red channel of the left image and the green channel of the right image as the reference to perform stereo matching of binocular disparity under the same blurs level. Furthermore, we introduce a method fusion binocular stereo matching and color-coded aperture depth from defocus cost function. The proposed methods are experiment under occlusion and blur condition. The results show that the matching accuracy is improved 20%. And the proposed algorithm is outperformance under mismatch and occlusion condition in binocular stereo matching.
Algebras of Functions on Compact Quantum Groups

The structures of Poisson Lie groups on a simple compact group are parametrized by pairs (α,w), where aeR, ueA2\)R, and ί)R is a real Cartan subalgebra of complexifϊcat ion of Lie algebra of the group in question. In the present article the description of the symplectic leaves for all pairs (α, u) is given. Also, the corresponding quantized algebras of functions are constructed and their irreducible representations are described. In the course of investigation Schubert cells and quantum tori appear. At the end of the article the quantum analog of the Weyl group is constructed and some of its applications, among them the formula for the universal ^-matrix, are given.
A study of the predictability of the ECMWF operational forecast model in the tropics

Examen de la predicibilite, dans la zone tropicale, du modele operationnel du CEPMMT (ECMWF), a l'aide des donnees 1983-1984. On a examine separement la dynamique quasi stationnaire a tres grande echelle, pour une echelle de temps superieure a 30 jours, et la dynamique transitoire a l'echelle de 3-10 jours. Resultats: la predicibilite pour la premiere dynamique n'est que de 2 jours; la plus grande partie de l'erreur relative a une prevision a 7 jours, a un caractere systematique, cette derniere a une structure de mode de Rossby, interne, symetrique, le plus bas, de nombre d'ondes zonal 1, croissant sans propagation; la cause en serait une faiblesse dans la parametrisation de la convection; la predicibilite pour la seconde dynamique est examinee a l'aide de la methode de filtrage temporel; on trouve 4 jours ou plus pour l'Atlantique central ou le Pacifique central; l'indice de prevision est faible pour les parties orientales du Pacifique ou les perturbations se developpent sous forme d'orages tropicaux; faiblesse egalement dans l'ocean Indien ou le vent calcule par satellite n'est pas disponible
Coverings of Cubic Graphs and 3-Edge Colorability

Abstract Let h:G˜→G h:\tilde G \to G be a finite covering of 2-connected cubic (multi)graphs where G is 3-edge uncolorable. In this paper, we describe conditions under which G˜ \tilde G is 3-edge uncolorable. As particular cases, we have constructed regular and irregular 5-fold coverings f:G˜→G f:\tilde G \to G of uncolorable cyclically 4-edge connected cubic graphs and an irregular 5-fold covering g:H˜→H g:\tilde H \to H of uncolorable cyclically 6-edge connected cubic graphs. In [13], Steffen introduced the resistance of a subcubic graph, a characteristic that measures how far is this graph from being 3-edge colorable. In this paper, we also study the relation between the resistance of the base cubic graph and the covering cubic graph.
Immunohistochemical Profiling of PD-1, PD-L1, CD8, MSI, and p53 and Prognostic Implications in Advanced Serous Ovarian Carcinoma: A Retrospective Study

Advanced high-grade serous ovarian carcinoma is a serious malignant neoplasm with a late diagnosis and high mortality rate. Even when treated with standard therapy, such as surgery followed by carboplatin and paclitaxel chemotherapy, the prognosis remains unfavorable. Immunotherapy is a treatment alternative that requires further study. Therefore, we aimed to evaluate the expression of PD-1, PD-L1, CD8, MSI (MLH1, MSH2, MSH6, and PMS2), and p53 in the paraffin samples of high-grade serous ovarian carcinoma. A retrospective study of 28 southern Brazilian patients with advanced serous ovarian carcinoma (EC III or IV) was conducted between 2009 and 2020. The expression of these proteins was evaluated using immunohistochemistry, and the results were correlated with the patients’ clinicopathological data. At diagnosis, the mean age was 61 years, and the most common clinical stage (60%) was EC III. Among the cases, 84.6% exhibited p53 overexpression, 14.8% had MSI, 92.0% were sensitive to platinum, and more than 50.0% relapsed after treatment. Patients with MSI had a lower CD8/PD-1 ratio and more relapses (p = 0.03). In conclusion, analysis of immunotherapeutic markers in paraffin-embedded advanced serous ovarian carcinoma samples is feasible and may assist in prognosis.
Hierarchical Testing of a Primary and a Secondary Endpoint in a Group Sequential Design With Different Information Times

ABSTRACT We consider a confirmatory clinical trial where a primary and a secondary endpoints are tested hierarchically to control the family-wise error rate at level α. The trial uses a group sequential design with an interim and a final analysis. When the information times at the interim analysis are the same for the primary and the secondary hypotheses, it has been shown in the literature that the secondary hypothesis has to be tested using a group sequential boundary at a level no more than α. In many event-driven trials, however, the information times are usually different because of different event rates for the two endpoints. The information times may also be different for a noninferiority hypothesis and a superiority hypothesis due to different analysis sets. We consider this general setup and derive a sharp upper bound on the probability of rejecting the secondary hypothesis at an interim and a final analysis. This bound suggests that the secondary boundary can be refined so that the group sequential design can be tested at a significance level greater than α while still controlling the family-wise error rate at level α. We carry out a simulation study to illustrate the power gain by using the refined boundary for different choices of boundaries for the two hypotheses. The proposed approach is illustrated in two oncology clinical trials with more than two analyses.
Synthesis, Characterization and Activity Test of Natural Zirconium Zeolite (Zr-ZA) Catalyst in The Esterification Reaction of Glycerol with Acetic Acid Anhydride

Synthesis of Zr-ZA catalyst used as catalyst for esterification reaction of glycerol with acetic acid anhydrous has been done. Catalysts are characterized using an infrared spectrophotometer, X-ray diffraction, and measurement of surface acidity, while reaction products are characterized using a gas chromatography-mass spectrometer. Effect of catalyst acidity, reaction time and re-addition of acetic acid anhydrous studied by glycerol conversion and selectivity value of triacetin were yielded. Infra-red spectrophotometer and X-ray diffraction analysis of the catalyst showed that the synthesized catalyst was zirconium zeolite (Zr-ZA), while esterification analysis using a gas chromatography-mass spectrometer showed a triacetin product.
Miniaturisation of switched beam array antenna using phase delay properties of CSRR‐loaded transmission line

The application of phase delay property of complementary split-ring resonator (CSRR)-loaded transmission line in the miniaturisation of Butler matrix beam forming network is proposed. The design of left-handed transmission line and the influence of the capacitive stubs in the phase delay properties of the CSRR-loaded transmission line with a gap are presented. The CSRR-loaded transmission line with a 7 mm capacitive stub provides 93° more phase delay than the CSRR-loaded transmission line without the stubs. CSRR-loaded transmission line with capacitive stubs is applied to the phase compensating lines of 4 × 4 Butler matrix configurations, without disturbing the 90° hybrids and crossovers. The CSRR-loaded configuration exhibits a size reduction of 48% of the footprint of the conventional Butler matrix. The output of the miniaturised Butler matrix is connected to a linear microstrip antenna array of four radiating elements and its radiation parameters (beam pointing direction, beamwidth and sidelobe levels) are compared with that of an unloaded conventional 4 × 4 Butler matrix. The miniaturised switched beam-steering antenna exhibits similar radiation characteristics as that of a conventional switched beam antenna.
Accelerating the Fast Gradient Method

A set of accelerated first order optimisation algorithms for minimising strictly convex functions are proposed. Using only gradient information, these algorithms can achieve a worst-case convergence rate proportional to $ 1-\left(\frac{\mu}{L}\right)^{1/N}$ for $N = 1, 2, 3, \dots$ and can exceed that of the fast gradient method. However, the improvement in the rate of convergence comes at the expense of a loss of robustness. Robustness is recovered by using an adaptive restarting controller that guarantees iterate convergences and recovers the faster convergence rates.
Proposal of an administrative and financial software for community-based tourism centers in Ecuador

The purpose of this article is to provide a proposal for an administrative and financial software for community-based tourism centers (CBTC), based on a previous diagnosis carried out in 28 CBTCs in Ecuador. The purpose of this software is to support these centers in a better management of their enterprises by means of an adequate management of their economic and human resources for the whole community benefit, considering the functions of administration: planning, implementation, monitoring and evaluation. For its design the PHP programming language and the Dream Weaver and Notepad++ programs were used, the software is easy and simple to use, considering the particularities of these community centers. It has 4 sections: Administrative, financial, Inventories and Inventories by consignment, each of these sections has its respective menu where the required information is entered and tracked. The reports generated will be useful for decision making and continuous improvement of these ventures.
Exploring the Therapeutic Potential of Phosphorylated Cis-Tau Antibody in a Pig Model of Traumatic Brain Injury

Traumatic brain injury (TBI) results in the generation of tau. As hyperphosphorylated tau (p-tau) is one of the major consequences of TBI, targeting p-tau in TBI may lead to the development of new therapy. Twenty-five pigs underwent a controlled cortical impact. One hour after TBI, pigs were administered either vehicle (n = 13) or PNT001 (n = 12), a monoclonal antibody for the cis conformer of tau phosphorylated at threonine 231. Plasma biomarkers of neural injury were assessed for 14 days. Diffusion tensor imaging was performed at day 1 and 14 after injury, and these were compared to historical control animals (n = 4). The fractional anisotropy data showed significant white matter injury for groups at 1 day after injury in the corona radiata. At 14 days, the vehicle-treated pigs, but not the PNT001-treated animals, exhibited significant white matter injury compared to sham pigs in the ipsilateral corona radiata. The PNT001-treated pigs had significantly lower levels of plasma glial fibrillary acidic protein (GFAP) at day 2 and day 4. These findings demonstrate a subtle reduction in the areas of white matter injury and biomarkers of neurological injury after treatment with PNT001 following TBI. These findings support additional studies for PNT001 as well as the potential use of this agent in clinical trials in the near future.
Dysfunctional Schemas from Preadolescence as One Major Avenue by Which Meaning Has Impact on Mental Health

A main way by which meaning influences mental health is by the formation of interpersonal schemas that specify what to expect from others and how to treat them. Particularly during preadolescence (a developmental phase focused on interpersonal skills), young people living in a stressful or hurtful environment can form atypical schemas that can help them survive but that produce serious problems when later applied to newly forming adult relationships. We provide three case studies illustrating this process. A boy learned to cope by withdrawing from social interaction and excelling in schoolwork. A girl learned to cope by denying her own needs and sacrificing herself for the welfare of others. Another girl coped by pervasive distrust of others and by becoming assertively independent. These children learned well enough to adapt to these dysfunctional relationships so as to suffer as little as possible, and they even developed some personal skills and resources. However, the rigid schemas had a destructive impact on their adult relationships. Proposals for interventions to change meaning and behaviors are discussed.