Miracle-dz/UniFAR-FTUs huggingface dataset:
Atorvastatin in stroke: a review of SPARCL and subgroup analysis

: Statin therapy in patients with cardiovascular disease is associated with reduced incidence of stroke. The Stroke Prevention by Aggressive Reduction of Cholesterol Levels (SPARCL) trial showed daily treatment with 80 mg of atorvastatin in patients with a recent stroke or transient ischemic attack (TIA) reduced the incidence of fatal or nonfatal stroke by 16%. Several post hoc analyses of different subgroups followed the SPARCL study. They have not revealed any significant differences when patients were sorted by age, sex, presence of carotid disease or type of stroke, with the exception of intracranial hemorrhage as the entry event. Lower low-density lipoprotein cholesterol levels in addition to possible neuroprotective mechanisms due to atorvastatin treatment correlate with improved risk reduction. Although not predefined subgroups and subject to an insufficient power, these post hoc studies have gener-ated new clinical questions. However, clinicians should avoid denying therapy based on such subgroup analysis. At this point, the best evidence powerfully demonstrates stroke and TIA patients should be prescribed high dose statin therapy for secondary stroke prevention.
Asian dust weather categorization with satellite and surface observations

This study categorizes various dust weather types by means of satellite remote sensing over central Asia. Airborne dust particles can be identified by satellite remote sensing because of the different optical properties exhibited by coarse and fine particles (i.e. varying particle sizes). If a correlation can be established between the retrieved aerosol optical properties and surface visibility, the intensity of dust weather can be more effectively and consistently discerned using satellite rather than surface observations. In this article, datasets consisting of collocated products from Moderate Resolution Imaging Spectroradiometer Aqua and surface measurements are analysed. The results indicate an exponential relationship between the surface visibility and the satellite-retrieved aerosol optical depth, which is subsequently used to categorize the dust weather. The satellite-derived spatial frequency distributions in the dust weather types are consistent with China's weather station reports during 2003, indicating that dust weather classification using satellite data is highly feasible. Although the period during the springtime from 2004 to 2007 may be not sufficient for statistical significance, our results reveal an increasing tendency in both intensity and frequency of dust weather over central Asia during this time period.
Soil Light Penetration and Dormancy of Jimsonweed (Datura stramonium) Seeds

Trials were carried out to determine the degree of light transmittance through soil and its role in photo-induced germination of buried weed seeds. Transmittance was found to be strongly dependent on soil type and decreased with decreasing particle size and with an increase in darker components. In each soil examined, light penetration fell below 0.01% at a depth of no more than 4 mm. It was also noted that with increasing soil depth, light permeability was proportional to wavelength, leading to progressive decline in the red-far red ratio. Low light penetration played a crucial role in germination of jimsonweed seeds, which had became light-sensitive after prolonged burial. Although this effect is a function of soil type, it may represent an important ecological factor influencing seed emergence in the first few mm of upper soil layers.
Prostaglandins and Other Lipid Mediators GE 2 through the EP 4 receptor controls smooth muscle gene expression patterns n the ductus arteriosus critical for remodeling at birth

The ductus arteriosus (DA) is a fetal shunt that directs right ventricular outflow away from pulmonary circulation and into the aorta. Critical roles for prostaglandin E2 (PGE2) and the EP4 receptor (EP4) have been established in maintaining both the patency of the vessel in utero and in its closure at birth. Here we have generated mice in which loss of EP4 expression is limited to either the smooth muscle (SMC) or endothelial cells and demonstrated that SMC, but not endothelial cell expression of EP4 is required for DA closure. The genome wide expression analysis of full term wild type and EP4−/− DA indicates that eywords: uctus arteriosus rostaglandins mooth muscle emodeling P4 onditional gene knockout PGE2/EP4 signaling modulates expression of a number of unique pathways, including those involved in SMC proliferation, cell migration, and vascular tone. Together this supports a mechanism by which maturation and increased contractility of the vessel is coupled to the potent smooth muscle dilatory actions of PGE2. © 2012 Elsevier Inc. All rights reserved.
Wind Tunnel Simulation on Flow Fields around Different Types of Sand Dikes

Sand dike plays an important role in the sand-control system.In this paper,wind tunnel experiments were conducted to simulate the protective effect of a series of sand dike models with different shapes,dip angles and heights.Results showed that:①Sand dikes affected the flow characteristics significantly.Five typical sub-areas in flow field around sand dike could be identified based on their flow characteristics: low-speed area before windward slope toe,resistance-confronting lifting area on the windward flank,mass flow accelerating area above the top of the dike,flow-sinking decelerating area of leeward slope and dissipating recovering area.The low-speed area before the dike and the mass flow accelerating area above the top of the dike could reduce wind speed and prevent sand transport. ②Considering the size of low-speed area before the dike body,the trapezoidal sand dike was better than the triangular one,but from the aspect of the effective shelter distance,the conclusion was just the opposite. ③The protective effect of the triangular sand dike reduced with the growth of the wind speed.The effective shelter distance of the triangular dike increased with the growth of the dip angle,while the low-speed area before the dike body decreased with the growth of the dip angle. ④The effective shelter distance of the triangular sand dike with a 40° dip angle was always the largest under four different wind velocities. ⑤The effective shelter distance on the lee flank of the sand dike was correlated with the height of the sand dike.
Self-assembling and Electrothermal Microactuators for Tunable Capacitors by Altug Oz

iii Chapter 1: Introduction . 1 1.1 Motivation.1 1.2 Previous Research . 2 1.2.1 Electrothermal Microactuators.2 1.2.2 RF MEMS Tunable Capacitors.5 Chapter 2: Design and Modeling.9 2.1 Self-assembling / Electrothermal Actuators.9 2.1.1 Basic Concepts of Self Assembly and CMOS Electrothermal Actuation.9 2.1.2 Nanometer-scale Gap Closing Mechanism.12 2.1. 3 Modeling of Micro-movers for Self-assembly and Electrothermal Actuation.13 2.1. 3.1 Simulations for the Displacement from Self-assembly.14 2.1. 3.2 Simulations for the Displacement from Electrothermal Actuation . 16 2.1. 3.3 Analytical Modeling of Thermal Time Constants and Frequency Response.16 2.1. 4 Latch Mechanism for Low Power Operation.19 2.1. 4.1 Vertical Latch Mechanism . 20 2.1. 4.2 Lateral Latch Mechanism.21 2.2 RF MEMS Tunable Capacitors.23 2.2.1 Gap & Area Tuning Topologies.24 2.2.1.1 Analytical Calculations for Tuning Ranges and Quality Factors.28 2.2.1.2 Simulations for Calculating Capacitance.36 2.2.2 Gap Tuning Topologies . 38 2.2.2.1 Analytical Calculations for Tuning Ranges and Quality Factors.38 2.2.2.2 Simulations for Calculating Capacitance.41
La sédimentation lacustre indicateur de changements des paléoenvironnements au cours des 30 O00 dernières années

Les resultats de l'analyse par spectrometrie infrarouge des echantillons de deux carottes prelevees dans deux depressions marecageuses de la Serra Sul dos Carajas (Amazonie Orientale), mettent en evidence cinq grandes etapes paleohydrologiques au cours des 30 O00 dernieres annees. La comparaison avec les resultats de la palynologie permet de mieux comprendre l'impact de changements climatiques brefs sur les paleoenvironnements.
National Assessment Report of Climate Change (I): Climate change in China and its future trend

The climate change in China shows a considerable similarity to the global change, however, there still exist significant differences between them. In the context of the global warming, the annual mean surface temperature has significantly increased during the past 100 years, with slightly greater magnitude of temperature increase than the globe . The precipitation trends during the last 50 and 100 years are not obvious ,but since 1956 it has assumed a weak increasing trend. The frequency and intensity of main extreme weather and climate events have also assumed significant change. The research has shown that the CO2 emission in China has continuously increased and the sum of positive radiative forcings produced by greenhouse gases is responsible for climate warming. The projection of climate change for the 21 st century has indicated that in the future 20-100 years, the surface temperature will continue to increase and precipitation also has an increasing trend.
The Impact of Cultural Differences on Project Management in the Norwegian Oil and Gas Industry

2 1. Introduction . 3 1.1 Background . 3 1.1.1 The Norwegian culture . 4 1.2 Research Purpose . 6 1.3 Suitability of the researcher . 7 1.3.1 Academic background . 7 1.3.2 Work Background . 8 1.3. 3 Learning style . 8 1.4 Recipients of the research . 8 1.4.1 Main recipients . 8 1.4.2 Secondary recipients . 9 1.5 Limitations . 9 1.6 Dissertation outline . 10 2. Literature review . 11 2.1 The project management role . 11 2.2 Communication . 13 2.3 Cultural differences . 14 2.4 Norwegian oil and gas industry . 20 3. Research Methodology . 22 3.1 Research Purpose and objectives . 22 3.2 Methodology . 23 3.2.1 Research Philosophy . 23 3.2.2 Research Approach . 24 3.2.3 Research Strategy . 25 3.2.4 Research Choice . 25 3.2. 5 Time Horizon . 26 3.2. 6 Data Collection . 26 3.2. 7 Data Analysis . 27 3.2. 8 Sampling . 28 3.2. 9 Practical Effort . 28 3.2.10 Research Limitations . 30 3.2.11 Personal Biases . 31 3.2.12 Research Ethics . 31 4. Empirical findings and analysis . 33 4.1 Research Participants . 33 4.2 Empirical Findings . 34 4.2.1 What cultural differences exist in the Norwegian oil and gas industry? 34 4.2.2 How does cultural differences influence the communication between international tem members? 35 4.2.3 To what extend does cultural differences influence the project outcome? 40 4.2.4 How can project manager’s deal with cultural differences? 44 4.3 Analysis . 50 4.3.1 What cultural differences exist in the Norwegian oil and gas industry? 50 4.3.2 How does cultural differences influence the communication between international tem members? 51 4.3. 3 To what extend does cultural differences influence the project outcome? 53 4.3. 4 How can project manager’s deal with cultural differences? 55 5. Conclusion . 58 5.1 What cultural differences exist in the Norwegian oil and gas industry? 58 5.2 How does cultural differences influence the communication between international tem members? 58 5.3 To what extend does cultural differences influence the project outcome? 59 5.4 How can project manager’s deal with cultural differences? 60 5.5 Key Findings . 61 5.6 Implication for further research . 62 6. Self Refelction . 63 6.1 Introduction . 63 6.2 Reflection on Process . 63 6.3 Reflection on Sources . 64 6.4 Reflection on Dissertation Formulation . 65 6
Epidemiologia de les neoplàsies limfoides a les comarques de tarragona, 1980-2004

Es tracta d'un estudi epidemiologic de les neoplasies limfoides a Tarragona. Es donen dades d'incidencia, mortalitat, supervivencia i prevalenca en base poblacional de les 3.258 neoplasies limfoides del Registre de Cancer de Tarragona durant el periode 1980-2004 ( 354 limfomes de Hodgkin, 1605 limfomes no-Hodgkin (LNH), 676 mielomes multiples, 188 leucemies limfatiques agudes i 435 leucemies limfatiques croniques). S'ha estudiat la tendencia temporal de la incidencia i la seva projeccio a 2010 i 2015 per a cada grup de malalties. Els LNH s'han classificat histologicament d'acord amb la classificacio de l'OMS de les neoplasies hematologiques, i s'han establert comparacions internacionals. Les principals conclusions han estat que les neoplasies limfoides a Tarragona mostren un patro epidemiologic occidentalitzat, amb una progressiva millora en la seva supervivencia relativa, i que existeix, almenys parcialment, una relacio temporal entre la epidemia de la SIDA i la dels LNH.
Occurrence and Emplacement of Chromite Ores in Sindhudurg District, Maharashtra, India

In the present study, we present the occurrence and emplacement of chromite ore deposits from two abandoned mines (Kankavali [Janoli] and Wagda) in the Sindhudurg district of Maharashtra, India. These ores, that occurred as lenses and are associated with metamorphic and ultrabasic rocks, consist of octahedral grains of chromite, while clinochlore is present between the interstices of these grains. The Kankavali (Janoli) and Wagda ores revealed a dominance of Cr2O3 followed by FeO and variable proportions of A12O3, MgO, and SiO2. The former deposits have a slightly higher Cr2O3 (average 52 wt%) and FeO (∼18 wt%) than those from Wagda (Cr2O3∼50 wt%, FeO ∼25 wt%). The similar Cr# values (0.73 for Kankavali [Janoli], 0.74 for Wagda) correspond to those reported for typical podiform‐type chromite deposits. We suggest that the ores were emplaced as phacoliths in folded outcrops with a steep easterly dip and a northwest–southeast trend. We postulate the continuation of the fold structure from Janoli to Wagda (∼4.5 km apart) and the probable (sporadic) occurrence of chromite along this stretch. The possibility of the contribution of chromite grains from these areas to the coastal placer deposits cannot be ruled out.
Wave-Induced Pressures in Beds of Sand

Measurements of the variation of the fluctuating component of pressure have been made in two different beds of sand in a wave channel. The sand was laid from an overhead hopper, and it is shown that the stratification of the bed produced by this method causes the permeability to be different in the vertical and horizontal directions. It is suggested that a similar situation exists in the sea bed. Analytical relationships for the pressure and velocity distributions in such a situation are developed, and the agreement between theory and experiment is found to be quite good. As far as is known, this is the first time that the applicability of traditional porous-media analytical methods to wave-induced flow in beds of sand has been verified experimentally.
hydrochloride-loaded microsponges in

Diltiazem hydrochloride, topically applied at 2% concentration, is considered e ff ective for the treatment of chronic anal fi ssures, although it involves several side e ff ects among which anal pruritus and postural hypotension. To test the hypothesis that a sustained delivery system of diltiazem hydrochloride may be helpful for the treatment of chronic anal fi ssures, in the present study we evaluated the potential of gels containing diltiazem hydrochloride entrapped in microsponges. Such microsponges were based on Eudragit RS 100 and the e ff ect of some formulation variables was assessed by a 2 3 full factorial screening design. An optimized formulation of diltiazem hydrochloride microsponges was dispersed in Methylcellulose 2% or Poloxamer 407 20% and the resulting gels (micro-l-diltiazem hydrochloride 2%) were subjected to in vitro drug release, ex vivo permeability and drug deposition after application on porcine rectal mucosa. The results showed a prolonged release up to 24 h from micro-l-diltiazem hydrochloride at 2% in the gels. The permeation tests revealed up to 18% higher drug retention on the mucosal tissue after 24 h by the micro-l-diltiazem hydrochloride 2% gels compared to conventional diltiazem hydrochloride gels at 2%. These results suggest that diltiazem hydrochloride-loaded microsponges dispersed in rectal gels may be useful to overcome some limitations of conventional local chronic anal fi ssure therapy.
Whole – body Vibration

As a therapy, whole body vibration (sometimes abbreviated as WBV) was explored by Russian scientist Vladimir Nazarov, who tested vibration on cosmonauts in an effort to decrease the loss of muscle and bone mass in space. As there is minimal gravitational force in space, muscles and bones are not loaded as they normally are on earth. Cosmonauts (and astronauts) in space lose their muscular strength very quickly, which is why they are not able to easily walk when they come back to earth. The decrease of bone density increases the risk of bone fractures, so it's not safe to stay in space for extended periods. The aerospace industry in the former Soviet Union worked with vibration training. Before their departure, cosmonauts were subjected to special training sessions so that the density of their bones would increase and their muscular strength would rise.
What are the barriers faced by patients using insulin ? A qualitative study of Malaysian health care professionals ’ views

1Department of Primary Care Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 2Department of Family Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 3Department of Nursing Science, University of Malaya, Kuala Lumpur, Malaysia; 4Faculty of Medicine Dean’s Office, University of Malaya, Kuala Lumpur, Malaysia; 5Klinik Kesihatan Pantai, Kuala Lumpur, Malaysia; 6Klinik Alam Medic, Puchong, Selangor, Malaysia
Prediction of Plasmid Hosts Using Random Forest

Plasmids play a major role facilitating the spread of antimicrobial resistance between bacteria. Understanding the host range and dissemination trajectories of plasmids is critical for surveillance and prevention of antimicrobial resistance. Identi ﬁ cation of plasmid host ranges could be improved using automated pattern detection methods compared to homology-based methods due to the diversity and genetic plasticity of plasmids. In this study, we developed a method for predicting the host range of plasmids using machine learning — speci ﬁ cally, random forests. We trained the models with 8,519 plasmids from 359 different bacterial species per taxonomic level; the models achieved Matthews correlation coef ﬁ cients of 0.662 and 0.867 at the species and order levels, respectively. Our results suggest that despite the diverse nature and genetic plasticity of plasmids, our random forest model can accurately distinguish between plasmid hosts. This tool is available online through the Center for Genomic Epidemiology (https://cge.cbs.dtu.dk/services/PlasmidHostFinder/).
Effects of recent 60 years climate change on net primary productivity of evergreen broad-leaved forest in Tiantong region of Zhejiang Province

Based on the 1954-2009 daily meteorological data of Tiantong region,and using Zhou Guangsheng's net primary productivity(NPP)model,this paper studied the recent 60 years climate change pattern and its effects on the NPP of evergreen broad-leaved forest in the region.In recent 60 years,the monthly average values of air temperature,precipitation,and reference evaportranspiration(ET0)in the region had an obvious increase in July and August,and the annual mean air temperature,precipitation,and ET0 increased significantly(P0.001). The NPP of the evergreen broad-leaved forest in 56 years was averagely 12.196 t·hm-2·a-1,and increased significantly in recent 60 years(P0.0001). In the future,if the air temperature increased by 2 ℃ and the precipitation increased by 20%,the NPP of the evergreen broad-leaved forest in the region would be increased by 15.9%;if the air temperature increased by 2 ℃2.1 and the precipitation decreased by 20%,the NPP would be decreased by 4.9%;and,if the air temperature increased by 2 ℃ and the precipitation was unchanged,the NPP would be increased by 5.5%. Annual average precipitation,ET0,and air temperature were the main meteorological factors affecting the NPP of evergreen broad-leaved forest in the region.
Revue générale Cancer anal et papillomavirus humains : une pathologie en miroir de celle du cancer du col utérin Anal cancer and human papillomaviruses : A perspective based on the cervical cancer model

Anal cancer is a rare pathology in the general population but the incidence of this cancer has been on the rise for certain high-risk groups, such as homosexual men and immunodepressed subjects. The incidence of anal cancer is 10 times higher in the HIV-positive population than in the female population in general. Moderate to severe dysplasias (AIN2-3) are types of precancerous lesions that usually precede the appearance of the cancer. HPV16 infection is the most common (3/4 of the cases) followed by HPV18 (less than 10%). In anal cancer, HPV16 is present in over 75% of the cases. The prevalence of HPV in anal cancer is higher in women (90%) than in men (75%). Squamous cervical and anal cancers have strong similarities founded on the causal association to HPV, in particular HPV16. Recent data indicate that antiHPV vaccination has a significant potential in preventing HPV infections, precancerous lesions, and anal cancer in the general population as well as in the high-risk groups. 2010 Elsevier Masson SAS. All rights reserved. Les deux cancers HPV associés les plus fréquents sont le cancer du col et le cancer de l’anus [1]. Les deux se développent sur le revêtement épithélial pavimenteux. Ils sont similaires par leur biologie et leur mécanisme de carcinogenèse. Comme pour le col utérin, les preuves se sont accumulées ces dernières années sur l’association causale des HPV dans la genèse des néoplasies intraépithéliales anales (AIN) et des cancers de l’anus. 1. Histoire naturelle La cellule cible des HPV est la cellule basale de l’épithélium ; de fait, la zone de jonction est le lieu privilégié de pénétration des Adresses e-mail : jmonsonego@wanadoo.fr, admin@eurogin.com. 1297-9589/$ – see front matter 2010 Elsevier Masson SAS. Tous droits réservés. doi:10.1016/j.gyobfe. 2010.02. 003 papillomavirus directement au contact de la couche basale. Les cancers du col, comme les cancers de l’anus, se développent sur la zone de transformation, site privilégié d’affrontement de l’épithélium cylindrique et l’épithélium pavimenteux au niveau de la zone de jonction. Cependant, les microtraumatismes peuvent également donner accès à cette couche basale au niveau périet endoanal. L’infection à papillomavirus est asymptomatique durant plusieurs mois ou années. L’infection latente ne se traduit par aucune anomalie morphologique. Dans plus de 80 % des cas, l’infection à papillomavirus est transitoire, l’immunité naturelle permet l’élimination du virus [2]. La persistance virale précède les anomalies morphologiques, cette phase peut durer de un à cinq ans avant de voir apparaı̂tre des modifications morphologiques des cellules infectées. Les lésions de bas grade, AIN1 ou dysplasies Fig. 2. Prévalence des HPV6, 11, 16 et 18 dans 413 AIN1 et 392 AIN2-3 chez les VIH+ et 955 cancers anaux de la population générale.