Miracle-dz/UniFAR-FTUs huggingface dataset:
And [They] Even Followed Her Into the Hospital: Primary Care Providers’ Attitudes Toward Referral for Traditional Healing Practices and Integrating Care for Indigenous Patients

Introduction/Importance: Given the promise of integrating traditional healing practices into primary care, we sought to examine the influence of primary care providers’ racial concordance and Indigenous patients’ ethnic salience on traditional healing treatment decisions. Method: Using a descriptive comparative design with an online clinical case vignette, we measured provider decision making via a 5-point Provider Acceptance of Traditional Healing–Referral and Consult questionnaire. Aggregated results of the main effects and interactional effects were analyzed using a 2 × 2 analysis of variance between-subjects design. Results: The main effect for patient racial concordance on the dependent variable was significant, F(1, 89) = 5.71, p = . 02. Conclusions: Provider–patient racial concordance does increase the providers’ likelihood of consulting with and referring patients to traditional healing practices, regardless of the patient’s ethnic salience. Implications for Practice: All health care providers require training in traditional healing practices for Indigenous persons as guided by the cultural safety framework.
SPARC expression in resected pancreatic cancer patients treated with gemcitabine : results from the CONKO-001 study

for patients with unresectable liver-only metastases from colorectal cancer: a North Central Cancer Treatment Group Phase II Study. J Clin Oncol 2005; 23: 9243–9249. 14. Adam R, Wicherts DA, de Haas RJ et al. Patients with initially unresectable colorectal liver metastases: is there a possibility of cure? J Clin Oncol 2009; 27: 1829–1835. 15. Chibaudel B, Maindrault-Goebel F, Lledo G et al. Can chemotherapy be discontinued in unresectable metastatic colorectal cancer? The GERCOR OPTIMOX2 Study. J Clin Oncol 2009; 27: 5727–5733. 16. Adams RA, Meade AM, Seymour MT et al. Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet Oncol 2011; 12: 642–653. 17. Weeks JC, Catalano PJ, Cronin A et al. Patients’ expectations about effects of chemotherapy for advanced cancer. N Engl J Med 2012; 367: 1616–1625. 18. Mende M, Trautmann K, Rentsch A et al. Patients’ perspectives on palliative chemotherapy of colorectal and non-colorectal cancer: a prospective study in a chemotherapy-experienced population. BMC Cancer 2013; 13: 66. 19. Rees M, Tekkis PP, Welsh FK et al. Evaluation of long-term survival after hepatic resection for metastatic colorectal cancer: a multifactorial model of 929 patients. Ann Surg 2008; 247: 125–135. 20. Spelt L, Andersson B, Nilsson J et al. Prognostic models for outcome following liver resection for colorectal cancer metastases: a systematic review. Eur J Surg Oncol 2012; 38: 16–24. 21. Folprecht G, Schuette K, Stoehlmacher J et al. Cetuximab and FOLFOXIRI: doseescalation study in previously untreated patients with metastatic colorectal cancer. Proc Gastrointest Canc Symp (ASCO/AGA/ASTRO/SSO), abstract 480. 2010. 22. Falcone A, Cremolini C, Masi G et al. FOLFOXIRI/bevacizumab (bev) versus FOLFIRI/bev as first-line treatment in unresectable metastatic colorectal cancer (mCRC) patients (pts): results of the phase III TRIBE trial by GONO group. J Clin Oncol (Meeting Abstracts) 2013; 31: 3505.
Blocking endogenous peroxidases: a cautionary note for immunohistochemistry

Dear Editor, In two recent JCMM papers dealing with the staining of various human tissue antigens, divergent approaches for blocking endogenous peroxidase activity were reported. As such, Gray et al.[1] inhibited this intrinsic enzyme with a 0.9% hydrogen peroxide (H2O2) solution whereas Ranieri et al.[2] performed the blockade with a 3% H2O2 solution. This arbitrariness has prompted our present letter. Immunohistochemistry (IHC) applied to formalin-fixed, paraffin-embedded tissue samples is governed by standard operating procedures like any other methodology in biomedicine. One important milestone in IHC standardization has been the revelation of endogenous biotin as a confounding factor along with measures to minimize its contribution to causing staining errors [3–5]. However, IHC pitfalls can also have other origins such as the insufficient quenching of endogenous peroxidases whenever using peroxidase-based detection methods. Despite the existence of expert manuals according to which these enzymes should be inhibited by applying a solution containing 3% H2O2[6] and studies abiding by this recommendation [2, 5, 7–9], some research groups still publish staining approaches in which blockade has erroneously been performed with less concentrated H2O2 solutions, e.g. by means of a 0.9%[1] or even 0.3%[10] solution. In this context, it was already shown that, for instance, when endogenous peroxidases were blocked by means of a 0.3% H2O2 solution a breast carcinoma was (falsely) positive for a particular protein, yet when blockade was performed by employing a 3% H2O2 solution, the same specimen stained negatively for that antigen [9]. It should be emphasized that all other conditions including primary antibody concentrations were identical in the two experimental arms at a given incubation temperature [9]. Therefore, the purpose of this note is to alert investigators to henceforth implement established techniques to avoid this mistake in order to prevent the emergence of staining artifacts associated with falsely positive IHC results and consequently augment the comparability of data generated in different laboratories on the same subject of interest. Given the increasing importance of proteomics and (intracellular) protein biomarkers for the diagnosis of human disease, appropriate countermeasures to avert this immunohistochemical pitfall should have particular relevance.
Acute achilles tendinopathy diagnosed with ultrasound.

A 72-yr-old woman presented with a complaint of left ankle pain, which was 4 of 10 on the visual analog scale. Ultrasound (US) evaluation of the left posterior and the left lateral ankle was obtained using high-resolution gray scale and color Doppler imaging (Figs.1 and 2). The sonographic evaluation demonstrated marked thickening of the Achilles tendon with heterogeneous echogenicity. Numerous foci of calcifications and marked hyperemia were noted within the tendon. These findings represent severe tendinopathy of the Achilles tendon. After failing multiple conservative therapies, the patient opted for a surgical debridement of her Achilles tendon. Her symptoms improved after finishing postoperative physical therapy. Tendinopathy is often considered to be a chronic degenerative condition, but there are acute exacerbations or Bflare-ups[ that can occur at any age. The cause of degeneration of the tendon is recurrent microtrauma and inadequate healing caused by the relative hypovascularity of the tendon. As the tendon becomes damaged, it becomes thickened, inelastic, and fibrotic. The differential diagnosis of Achilles tendon pain includes Achilles tendinopathy and rupture, calcaneal bursitis, and calcaneal apophysitis. In individuals with Achilles tendinopathy, pain is described as burning, located 2Y6 cm above the posterior calcaneus. In individuals with a tendon rupture, they describe their pain as severe and acute in nature, with some hearing a Bpop[ before the onset of pain. Absence of pain does not rule out rupture. Treatment of Achilles tendinopathy generally consists of avoiding intense physical activities, applying ice, using nonsteroidal anti-inflammatory drugs, and supporting the Achilles tendon with a heel lift when appropriate. Achilles tendinopathy is a clinical diagnosis, but changes in the tendon may be seen on radiologic imaging. US is a rapidly performed examination with greater resolution than that of magnetic resonance imaging (MRI) and allows dynamic evaluation of the tendons and the muscles. The use of US continues to increase for the evaluation of the musculoskeletal system. It is an attractive option to help diagnose Achilles tendon injuries because of the lower cost than that of MRI, lack of ionizing radiation,
Detecting Cyberattack Entities from Audit Data via Multi-View Anomaly Detection with Feedback

In this paper, we consider the problem of detecting unknown cyberattacks from audit data of system-level events. A key challenge is that different cyberattacks will have different suspicion indicators, which are not known beforehand. To address this we consider a multi-view anomaly detection framework, where multiple expert-designed “views” of the data are created for capturing features that may serve as potential indicators. Anomaly detectors are then applied to each view and the results are combined to yield an overall suspicious-ness ranking of system entities. Unfortunately, there is often a mismatch between what anomaly detection algorithms ﬁnd and what is actually malicious, which can result in many false positives. This problem is made even worse in the multi-view setting, where only a small subset of the views may be relevant to detecting a particular cyberattack. To help reduce the false positive rate, a key contribution of this paper is to incorporate feedback from security analysts about whether proposed suspicious entities are of interest or likely benign. This feedback is incorporated into subsequent anomaly detection in order to improve the suspiciousness ranking toward entities that are truly of interest to the analyst. For this purpose, we propose an easy to implement variant of the perceptron learning algorithm, which is shown to be quite effective on benchmark datasets. We evaluate our overall approach on real attack data from a DARPA red team exercise, which include multiple attacks on multiple operating systems. The results show that the incorporation of feedback can signiﬁcantly reduce the time required to identify malicious system entities.
Enhancement and Correction of Medical Images Using Multiscale Retinex

The Retinex is an image enrichment algorithm that improves the brightness, contrast and sharpness of an image. A new method for enhancing the contrast of inhomogeneous images by retinex algorithm is proposed. It can correct the blurring in deep anatomical structures and in homogeneity. Multi scale retinex (MSR) employed SSR with different weightings to correct in homogeneities and enhance the contrast of images”. Its performance was also compared with other methods based on two indices: (1) the peak signal-to-noise ratio (PSNR) and (2) the contrast-to-noise ratio (CNR).
Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures

Significance The epilepsies are a class of chronic neurological disorders with diverse clinical presentations, which often negatively impacts quality of life. Currently available therapeutics are effective for some patients, but roughly one-third of patients remain drug-resistant; the identification of novel therapeutic targets to alleviate seizures is therefore required. We have determined that potentiating Cl− extrusion in vivo reduces susceptibility to chemoconvulsant-induced seizures. Our results provide insights into the importance of controlling the polarity of GABAergic synaptic signaling under conditions of hyperexcitation, and highlight KCC2 as a potential therapeutic target for epilepsy. The type 2 K+/Cl− cotransporter (KCC2) allows neurons to maintain low intracellular levels of Cl−, a prerequisite for efficient synaptic inhibition. Reductions in KCC2 activity are evident in epilepsy; however, whether these deficits directly contribute to the underlying pathophysiology remains controversial. To address this issue, we created knock-in mice in which threonines 906 and 1007 within KCC2 have been mutated to alanines (KCC2-T906A/T1007A), which prevents its phospho-dependent inactivation. The respective mice appeared normal and did not show any overt phenotypes, and basal neuronal excitability was unaffected. KCC2-T906A/T1007A mice exhibited increased basal neuronal Cl− extrusion, without altering total or plasma membrane accumulation of KCC2. Critically, activity-induced deficits in synaptic inhibition were reduced in the mutant mice. Consistent with this, enhanced KCC2 was sufficient to limit chemoconvulsant-induced epileptiform activity. Furthermore, this increase in KCC2 function mitigated induction of aberrant high-frequency activity during seizures, highlighting depolarizing GABA as a key contributor to the pathological neuronal synchronization seen in epilepsy. Thus, our results demonstrate that potentiating KCC2 represents a therapeutic strategy to alleviate seizures.
ON THE ENTROPY OF UNIQUELY ERGODIC TRANSFORMATIONS

0. Introduction. Ergodic theory involves itself with the study of transformations of a measure space. Topological dynamics is involved with homeomorphisms of a topological space. The entropy of a measure preserving transformation is a gauge of its randomness. There are certain qualitative properties in topological dynamics which seem to play a similar role. For example, equicontinuity, distality, and minimality restrict the " randomness " of a transformation group. The question arises: If a measure preserving transformation is also a homeomorphism is there a strict relation between these notions? For instance it is known that equicontinuity and distality imply zero entropy. It was not known whether minimality implied zero entropy. W. Parry raised the following question: Let X be a compact metric space and T a continuous map of X into itself. Suppose there is a unique T invariant probability measure and suppose (X, T) is minimal (every orbit is dense). Can (X, T) have positive entropy? The difficulty in answering such a question is the scarcity of a wide class of minimal, uniquely ergodic transformation groups (X, T). We give here a method of constructing minimal uniquely ergodic transformation groups (X, T). Furthermore our method is designed to show that there exist transformation groups (X, T), X a compact metric space, which are minimal and uniquely ergodic but have arbitrarily large finite entropy. Thus minimality and unique ergodicity do not bound the entropy of (X, T) and the answer to Parry's question is no. We carry out our program by constructing closed shift invariant subspaces of a sequence space. In ? 1 we establish some notation and terminology. In ? 2 and 3 we either modify or translate some known theorems into combinatorial terms which are to be used in the succeeding sections. In ? 4 we define the sequences which will be used to build the uniquely ergodic minimal pairs (X, T) of large but finite entropy. 5, 6, 7, 8 are used to carry out the detailed examination of the properties of our sequence. 9 indicates the modification necessary in ? 4 to show that the same construction can be done on bisequences and thus Tmay also be a homeomorphism. The results are summarized in Corollaries 8.14 and 9.7. The principal idea which makes our result possible is the weak law of large numbers. Lemmas 1.1 and 1.2 are merely forms of this law. The remainder is
Video Re-Use in Mathematics Teacher Education

This study examines the re-use of existing video records of practice (VRPs) in preservice mathematics teacher education. The research is based on 34 interviews with mathematics teacher educators from 24 different institutions across the United States and three other countries, who are re-using VRPs from online repositories, books with accompanying videos, and other online and offline sources. In this paper, we report on three different types of VRP re-use raised by our interview participants. We discuss the instructional goals they described as well as the learning activities in which the VRPs were used. This paper addresses the question, how do mathematics teacher educators make use of existing VRPs to support the professional learning of preservice teachers? The paper concludes with a discussion of what these findings mean for teacher educators who re-use VRPs as well as for those who produce VRPs that can be re-used in preservice teacher education. Suggested Citation Suzuka, K. , Frank, R. , Crawford, E. & Yakel, E. (2018). Video re-use in mathematics teacher education. In E. Langran & J. Borup (Eds.), Proceedings of Society for Information Technology & Teacher Education International Conference (pp. 329-336). Washington, D.C., United States: Association for the Advancement of Computing in Education (AACE). Copyright Notice “Copyright by AACE. Reprinted from the with permission of AACE (http://www.aace.org). ” [Final publication is available at: https://www.learntechlib. org/p/182544/] Kara Suzuka College of Education, University of Hawai'i at Mānoa, USA klms@hawaii.edu Rebecca D. Frank School of Information, University of Michigan, USA frankrd@umich.edu Erica Crawford School of Education, University of Michigan, USA zawackie@umich.edu Elizabeth Yakel School of Information. University of Michigan, USA yakel@umich.edu Suzuka, Frank, Crawford, & Yakel Video Re-Use in Mathematics Teacher Education Page 2 of 9 Introduction This study examines the re-use of existing video records of practice (VRPs) in preservice mathematics teacher education. The research is based on 34 interviews with mathematics teacher educators from 24 different institutions across the United States and three other countries who are re-using VRP from various sources: videos from online repositories, videos that accompany books, and VRPs from other online and offline sources. In this paper, we report on three different types of VRP re-use raised by our interview participants. We discuss the instructional goals they described as well as the learning activities in which the VRPs were used. This paper takes up the following questions: How do mathematics teacher educators make use of existing VRPs to support the professional learning of preservice teachers? What instructional goals do teacher educators try to achieve when reusing VRPs? In what types of activities did they re-use VRPs? The paper concludes with a discussion of what these findings mean for teacher educators who re-use VRPs, as well as for those who produce VRPs that can be re-used in preservice teacher education.
Chromosome Engineering in Mouse Embryonic Stem Cells: Addition and Elimination of Targeted Chromosomes

Human pluripotential stem cells, including both embryonic stem cells (ES cells) and induced pluripotent stem cells (iPS cells), possess self-renewing potency or the ability to differentiate into virtually any type of somatic cell. These features make them particularly advantageous as sources from which to generate specific types of human tissue cells in vitro for use in drug development and regenerative medicine. In most cases, however, human pluripotential cell lines and especially human ES cells can only be used in cell-based applications because of ethical issues. Animal models are therefore sought as an alternative to using human cells. An increasingly popular non-human primate model is the common marmoset (Callithrix jacchus). The recent successful creation of lentivirus-mediated transgenic marmosets provides a new animal model for human disease offering the powerful advantage of a close genetic relationship with humans (Sasaki et al., 2009), though this technique is not yet sufficiently developed for common use, and the numbers of monkeys available for experiments are limited. Mouse ES cells, meanwhile, still have great value as a research tool, even after the development of human pluripotent cells, as they can be used to create chimeric mice, achieve germline transmission, and generate normal offspring. The available genetic engineering technologies often employ an embryonic manipulation approach in mice, using mouse ES cells to examine the gain-of-function or loss-of-function effects associated with certain chromosomal regions in vivo. Recently, we have developed chromosome elimination cassettes (CEC) using a Cre-inverted loxP system that was first used in mouse ES cells. In this system, transient cre expression can initiate immediate chromosomal loss over the course of a few cell cycles in the recombinant cells. This technology was developed to clarify chromosomal function through observing loss-offunction at the chromosomal level. In mammalian cells, chromosome composition and gene dosage are kept stable because large chromosome-wide deletions are usually fatal. Accordingly, we first applied the Cre-inverted loxP system to tetraploid cells composed of mouse ES cells fused with mouse somatic cells to generate conditions conducive to largescale chromosomal imbalance. The CEC-tagged chromosomes could be targets of Credependent chromosome elimination. In addition, we have demonstrated that the Creinverted loxP system enhances cohesion between a loxP site and an adjacent inverted loxP,
A Study of the Effect of Knowledge Management on Organizational Culture and Organizational Effectiveness in Medicine and Health Sciences

The usage of medical resources can meet required overall medial quality via the implementation of knowledge managements. At the same time, it allows medical professionals to understand and recognize the management strategy of the hospital. They will stay with the hospital and assist it in keeping its competitiveness and the goal of sustainable operations. Therefore, it is an important topic for hospital managements nowadays to realize this goal. Based on this consideration, the objective of this study is to investigate the influence of knowledge management on organizational culture and organizational effectiveness. The sampled subjects in this study include doctors and medical professionals in the city-level Grade III Level I hospital in Shanghai City. A total of 376 questionnaire copies were dispatched and a total of 266 copies were returned with an effective rate of response as 71%. The results of this study indicated the following findings. 1. There is a significantly positive correlation between knowledge management and organizational culture. 2. There is significantly positive correlation between organizational culture and organizational performance. 3. There is a significantly positive correlation between knowledge management and organizational performance. 4. The organizational culture has a mediation effect between knowledge management and organizational effectiveness. At the final stage of this study, we proposed our recommendations for the health care industry with an expectation that these could serve as the direction for stipulating health care policies in the future and a reference for the design of medical professional’s works, personnel incentive managements, and in-service trainings. Embodied recommendations were also proposed for the health care industry to promote knowledge management and the practical implementation of strategies.