Miracle-dz/UniFAR-FTUs huggingface dataset:
CARDIAN: a novel computational approach for real-time end-diastolic frame detection in intravascular ultrasound using bidirectional attention networks

Introduction Changes in coronary artery luminal dimensions during the cardiac cycle can impact the accurate quantification of volumetric analyses in intravascular ultrasound (IVUS) image studies. Accurate ED-frame detection is pivotal for guiding interventional decisions, optimizing therapeutic interventions, and ensuring standardized volumetric analysis in research studies. Images acquired at different phases of the cardiac cycle may also lead to inaccurate quantification of atheroma volume due to the longitudinal motion of the catheter in relation to the vessel. As IVUS images are acquired throughout the cardiac cycle, end-diastolic frames are typically identified retrospectively by human analysts to minimize motion artefacts and enable more accurate and reproducible volumetric analysis. Methods In this paper, a novel neural network-based approach for accurate end-diastolic frame detection in IVUS sequences is proposed, trained using electrocardiogram (ECG) signals acquired synchronously during IVUS acquisition. The framework integrates dedicated motion encoders and a bidirectional attention recurrent network (BARNet) with a temporal difference encoder to extract frame-by-frame motion features corresponding to the phases of the cardiac cycle. In addition, a spatiotemporal rotation encoder is included to capture the IVUS catheter's rotational movement with respect to the coronary artery. Results With a prediction tolerance range of 66.7 ms, the proposed approach was able to find 71.9%, 67.8%, and 69.9% of end-diastolic frames in the left anterior descending, left circumflex and right coronary arteries, respectively, when tested against ECG estimations. When the result was compared with two expert analysts’ estimation, the approach achieved a superior performance. Discussion These findings indicate that the developed methodology is accurate and fully reproducible and therefore it should be preferred over experts for end-diastolic frame detection in IVUS sequences.
Cathodal transcranial direct current stimulation over left 2 dorsolateral prefrontal cortex area promotes implicit motor 3 learning in a golf putting task 4

1 Background: Implicit motor learning is characterized by low dependence on working memory and stable 2 performance despite stress, fatigue, or multi-tasking. However, current paradigms for implicit motor 3 learning are based on behavioral interventions that are often task-specific and limited when applied in 4 practice. 5 Objective: To investigate whether cathodal transcranial direct current stimulation (tDCS) over the left 6 dorsolateral prefrontal cortex (DLPFC) area during motor learning suppressed working memory activity 7 and reduced explicit verbal-analytical involvement in movement control, thereby promoting implicit 8 motor learning. 9 Methods: Twenty-seven healthy individuals practiced a golf putting task during a Training Phase while 10 receiving either real cathodal tDCS stimulation over the left DLPFC area or sham stimulation. Their 11 performance was assessed during a Test phase on another day. Verbal working memory capacity was 12 assessed before and after the Training Phase, and before the Test Phase. 13 Results: Compared to sham stimulation, real stimulation suppressed verbal working memory activity after 14 the Training Phase, but enhanced golf putting performance during the Training Phase and the Test Phase, 15 especially when participants were required to multi-task. 16 Conclusion: Cathodal tDCS over the left DLPFC may foster implicit motor learning and performance in 17 complex real-life motor tasks that occur during sports, surgery or motor rehabilitation. 18
Répteis continentais do município de Rio Grande, Rio Grande do Sul, Brasil

O municipio de Rio Grande localiza-se na planicie costeira do Rio Grande do Sul, a oeste do estuario da Lagoa dos Patos. Essa regiao caracteriza-se por uma grande diversidade de ambientes tais como banhados, campos, matas de restinga, arroios e lagoas interiores, alem de um extenso litoral. O presente estudo teve como principal objetivo catalogar as especies de repteis continentais que ocorrem no municipio, amostrando atraves de diversos metodos como encontros visuais, instalacao de armadilhas (pitfall, covo aquatico e abrigos artificiais), observacoes sem coleta, analise de material doado por terceiros e consultas as colecoes herpetologicas de instituicoes de pesquisa do estado. Entre abril de 2003 e agosto de 2005 foram realizadas 161 coletas em sete locais do municipio, que abrangeram os ambientes de campo, matas, banhados e formacoes de dunas. Os metodos permitiram capturar 405 individuos representantes de 30 especies pertencentes a 25 generos, 12 familias e tres ordens, sendo que 11 especies de repteis Squamata foram pela primeira vez registradas para o municipio. Os resultados indicaram que a herpetofauna presente no municipio de Rio Grande tem uma forte similaridade com a herpetofauna do litoral uruguaio. Embora o municipio esteja sobre a Provincia Pampeana, e a maioria das especies de repteis ali presentes sao elementos tipicos dessa provincia zoogeografica.O municipio tambem possui especies tipicas das Provincias Tupi e principalmente, da Provincia Guarani. Palavras-chave: ecossistema costeiro, Crocodylia, Squamata, Testudines. ABSTRACT Continental reptiles from the municipality of Rio Grande, Rio Grande do Sul, Brazil Rio Grande is located in the coastal plain of Rio Grande do Sul state, to west of the Lagoa dos Patos estuary. This area is characterized by a great diversity of environments such as swamps, fields, Restinga forests, streams and interior ponds, besides an extensive coast. The present study had as main objective to make a list of the species of continental reptiles present in the municipality, collecting through several methods such as visual encounters, traps (pitfall, aquatic traps and artificial shelters), observations, and material analysis donated by collaborators. Between April 2003 and August 2005 we accomplished 161 collections at seven places of the municipality, covering environments such as natural field, native forests, swamps and dunes. The methods allowed the capture of 405 individuals representative of 30 species, belonging to 25 genera, 12 families and three orders, being 11 species of reptiles Squamata registered for the first time to the study area. Although Rio Grande is on Pampeana Province and most of the species of reptiles there are typical elements of this Zoogeographical Province.The city also possesses typical species of the Tupi Province and mainly of the Guarani Province. Key words: coastal ecosystem, Crocodylia, Squamata, Testudines.
Quetiapine for acute bipolar depression: a systematic review and meta-analysis

Background Precise estimated risks and benefits of quetiapine for acute bipolar depression are needed for clinical practice. Objective To systematically review the efficacy and the tolerability of quetiapine, either as monotherapy or combination therapy, for acute bipolar depression. Methods We included all randomized, controlled trials (RCTs) comparing quetiapine with other treatments, including placebo, in patients with acute bipolar depression (bipolar I or II disorder, major depressive episode). Published and unpublished RCTs were identified using the Cochrane Central Register of Controlled Trials, MEDLINE®, Web of Knowledge™, CINAHL®, PsycINFO®, the EU Clinical Trials Register database, and ClinicalTrials.gov. The primary outcome was the change scores of depression rating scales. Results Eleven RCTs (n=3,488) were included. Two of them were conducted in children and adolescents. The change in depression scores was significantly greater in the quetiapine group compared with the placebo group (mean difference, [MD] =−4.66, 95% confidence interval [CI] −5.59 to −3.73). The significant difference was observed from week 1. Compared with placebo, quetiapine had higher incidence rates of extrapyramidal side effects, sedation, somnolence, dizziness, fatigue, constipation, dry mouth, increased appetite, and weight gain but lower risks of treatment-emergent mania and headache. Quetiapine treatment was associated with significant improvement of clinical global impression, quality of life, sleep quality, anxiety, and functioning. Conclusion Quetiapine monotherapy is effective for acute bipolar depression and the prevention of mania/hypomania switching. Its common adverse effects are extrapyramidal side effects, sedation, somnolence, dizziness, fatigue, constipation, dry mouth, increased appetite, and weight gain. The lower risk of headache in quetiapine-treated patients with acute bipolar depression should be further investigated. The evidence for the use of quetiapine combined with mood stabilizers in children and adolescents with acute bipolar depression is too small to support the clinical practice.
Lipid nanoparticle-mediated delivery of mRNA for IL-21 achieves clearance of hepatitis B virus in mouse models

Chronic hepatitis B virus (HBV) infection causes hepatitis, liver cirrhosis and hepatocellular carcinoma. Covalently closed circular DNA (cccDNA) is the transcription template for HBV RNAs and not aﬀected by current treatment options. Eﬀective therapeutics with ability to remove cccDNA need to be developed. Previously, we established an HBV persistence mouse model via hydrodynamic injection of a clinical isolate (BPS) and identiﬁed IL-21 as a potent inducer of viral clearance. Here, we aimed to explore the anti-HBV eﬀects of IL-21 messenger RNA (mRNA) delivered by lipid nanoparticle (LNP-IL-21) system. First, LNP-IL-21 was prepared and analyzed for its safety, expression, biodistribution and stability in vitro and in vivo . Next, LNP-IL-21 was injected into two HBV persistence mouse models based on BPS and recombinant cccDNA (rcccDNA) respectively. LNP-IL-21 administration successfully cleared HBV serum markers, and more importantly, BPS replicons and rcccDNA in livers, which was associated with activation of viral speciﬁc immune responses. Notably, transfer of peripheral blood mononuclear cells from BPS persistence mice stimulated ex vivo with LNP-IL-21 and viral antigen could induce HBV clearance in recipient mice. These ﬁndings suggested that both LNP-IL-21-based gene and cellular therapies provided novel therapeutic strategies against chronic HBV infection
Calibration estimation in dual frame surveys

Multiple frame surveys are increasingly used by large statistical agencies and private organizations to reduce frame undercoverage errors and also sampling costs. Estimation for multiple frame surveys has been considered ever since the work of Hartley (1962). In this work we extend the tools of calibration estimation developed so far for single frame surveys to the case of dual frame surveys. Cali- bration allows to handle different types of auxiliary information and can be shown to encompass as a special case the pseudo empirical maximum likelihood approach recently proposed by Rao and Wu (2010).
Semipermeable boundaries and heterogeneities: Modeling by singularities

A semipermeable membrane (low permeability skin around a well) is modeled by a sink at the center of the well. The sink solution does not exist for thick or resistive skins. Seepage around a low permeability dam contour is modeled by a vortex. The curve, along which the third-type boundary condition holds, is reconstructed from the equation of the contour in polar coordinates. Flow around an impermeable dam in a porous medium containing a semiparabolic interface is studied analytically with the refraction condition, i.e., continuity of the head and normal flux along the interface between zones of contrasting permeability.
-Channel Compactly Supported Biorthogonal Cosine-Modulated Wavelet Bases

— In this correspondence, we generalize the theory of compactly supported biorthogonal two-channel wavelet bases to MMM -channel. A sufﬁcient condition for the MMM -channel perfect reconstruction ﬁlter banks to construct MMM -channel biorthogonal bases of compactly supported wavelets is derived. It is shown that the construction of biorthogonal MMM -channel wavelet bases is equivalent to the design of a MMM -channel perfect reconstruction ﬁlter bank with some added regularity conditions. A family of MMM -channel biorthogonal wavelet bases based on the cosine-modulated ﬁlter bank (CMFB) is proposed. It has the advantages of simple design procedure, efﬁcient implementation, and good ﬁlter quality. A new method for imposing the regularity on the CMFB’s is also introduced, and several design examples are given.
Integral sliding mode‐based event‐triggered nearly optimal tracking control for uncertain nonlinear systems

In this paper, an event‐triggered nearly optimal tracking control method is investigated for a class of uncertain nonlinear systems by integrating adaptive dynamic programming (ADP) and integral sliding mode (ISM) control techniques. An ISM‐based discontinuous control law with a neural network (NN) adaptive term is designed to eliminate the influence of the uncertainties and obtain the sliding mode dynamics which is equivalent to the tracking error dynamics without uncertainties, and relax the known upper‐bounded condition of uncertainties. In order to guarantee the stability of tracking error system and the considerable optimality, under the ADP technique, a critic NN is applied to approximate the optimal value function for solving the event‐triggered Hamilton‐Jacobi‐Bellman equation and the event‐triggered nearly optimal feedback control is obtained. The feedback control law is updated and transmitted to plant only when events occur, thus both the communication and the computational resources can be saved. Furthermore, the stability of tracking error is proven thanks to Lyapunov's direct method. Finally, we provide two simulation examples to validate the developed control scheme.
Biological treatment of crude oil contaminated soil in Russia

Abstract Oil spillage on land accounts for the majority of hydrocarbon contamination of our planet and bioremediation of these habitats is possible because of the existence of hydrocarbon-oxidizing microorganisms in situ and in culture collections. A number of physical, chemical and environmental factors affect the degradation of oil in soils including soil pore structure, aeration, toxic oil constituents and nutrient availability. In addition, strongly sorbed hydrophobic constituents, such as polycyclic aromatic hydrocarbons, are difficult to solubilize and make available for degradation. Various remediation techniques were used in field experiments on bioremediation of oil contaminated agricultural soils after an accidental oil-spill which occurred on the territory of the Mezhevskoe oilfield (‘Polaznaoil’ company). Composting systems were utilized to increase oxygen transfer with degradation further enhanced by combination of nutrient additions, bulking with straw and inoculations of Rhodococcus-biosurfactant complexes. After a three-month bioremediation the content of chloroform extracts decreased to 2.85–1.60% (from an initial amount of 3.75%). The percentage oil degraded varied from 24.0 to 57.1 depending on the remediation methods used. C02 evolution rates (36.1–54.6 µg g-1 day-1) indicated the intensity of aerobic oil degradation. It is not clear whether fertilization with NPK, and bulking, increased oil degradation rates in the systems used. Our initial results show that soil remediation progresses more effectively if composting systems are used with increased ventilation, nutrient additions and, particularly, inoculation of Rhodococcus-biosurfactant complexes.
Population dynamics of Saurida elongata and S. undosquamis (Synodontidae) in the southern Gulf of Thailand

Length-frequency data on Saurida elongata and S. undosquamis (Synodontidae) from bottom trawl survey conducted in 1984 in the Southern Gulf of Thailand were analyzed using the Compleat ELEFAN software. The seasonal pattern of recruitment suggests two uneven pulses per year, one stronger than the other. Yield-per-recruit analyses suggested that the investigated stocks are presently overexploited. Possible sources of bias for the analyses presented here are discussed.
Where does S‐wave energy on OBC recordings come from?

A study of wave-mode conversion that occurs at the sea floor for downgoing seismic energy and a comparison with reflected conversions at a representative interface of Tertiary sediments is presented. To investigate if the presence of Swaves on the vertical component (and P-wave in horizontal) could be due to mode conversion close to the receivers, conversion for up-going seismic energy in the shallow sediments is also analyzed. It is concluded that: 1) most Pto S conversion occurs as reflection at sediment interfaces, not at the sea-bottom, and 2) negligible mode-conversion (both Pto -S and Sto -P) occurs for the up-going seismic energy in the sediments and at the sea bottom.
Financial Crises and Economic Activity

We study the output costs of 40 systemic banking crises since 1980. Most, but not all, crises in our sample coincide with a sharp contraction in output from which it took several years to recover. Our main findings are as follows. First, the current financial crisis is unlike any others in terms of a wide range of economic factors. Second, the output losses of past banking crises were higher when they were accompanied by a currency crisis or when growth was low at the onset of the crisis. When accompanied by a sovereign debt default, a systemic banking crisis was less costly. And, third, there is a tendency for systemic banking crises to have lasting negative output effects.
Federal Reserve Bank of Minneapolis Research Department Sta Report 316 Financial Crises as Herds: Overturning the Critiques

Financial crises are widely argued to be due to herd behavior. Yet recently developed models of herd behavior have been subjected to two critiques which seem to make them inapplicable to financial crises. Herds disappear from these models if two of their unappealing assumptions are modified: if their zero-one investment decisions are made continuous and if their investors are allowed to trade assets with market-determined prices. However, both critiques are overturned–herds reappear in these models–once another of their unappealing assumptions is modified: if, instead of moving in a prespecified order, investors can move whenever they choose. and an anonymous referee for useful comments. We thank Kathy Rolfe for editorial assistance. We thank the National Science Foundation for financial support. The views expressed herein are those of the authors and not necessarily those of the Federal Reserve Bank of Minneapolis or the Federal Reserve System.
Crustal deformation in western Sichuan region and implications for 12 May 2008 Ms 8.0 earthquake

We have established 65 GPS stations and derive a detailed horizontal deformation distribution in western Sichuan region, in conjunction with previous measurements at additional 90 stations. The resulting velocity field shows that strike‐slip fault system here plays a significant role in adjusting crustal movements (in direction and magnitude) along the eastern borderland of the Tibetan Plateau. We find Xianshuihe fault is essentially creeping in its southeasternmost portion with left‐lateral slip rate of 8.4 ± 2.8 mm/a. We report ∼5.6 mm/a left‐lateral slip rate across Anninghe and Daliangshan fault. Mabian fault slips left‐laterally at the rate of 2.5 ± 1.4 mm/a with nearly null fault‐normal motion. Deformation across Litang and Yunongxi fault appear insignificant at present time. Our results reveal recently ruptured Longmenshan fault has both right‐lateral slip rate and compressional rate close to 2.0 ± 1.0 mm/a, implying that the Longmenshan fault indeed absorbs some northeastern motion of Tibetan Plateau and likely causes strain accumulation there, which leads to the breakout of the 12 May 2008 Ms 8.0 earthquake. We also find several domains with markedly localized strain rates, which are associated with individual structures.
Combining Formal Concept Analysis and Translation to Assign Frames and Thematic Role Sets to French Verbs

We present an application of Formal Concept Analysis in the domain of Natural Language Processing: We give a general overview of the framework, describe its goals, the data it is based on, the way it works and we illustrate the kind of data we expect as a result. More specifically, we examine the ability of the stability, separation and probability indices to select the most relevant concepts with respect to our FCA application. We show that the sum of stability and separation gives results close to those obtained when using the entire lattice.
Telehealth in the developing world: current status and future prospects

: In a setting of constant change and confusing terminology, telehealth continues to gain ground in both developed and developing countries within the overarching milieu of e-health. Evidence shows telehealth has been used in essentially all countries of the world, but is embedded in few. Uses and needs of telehealth vary between the developed and developing world; the latter struggles with both communicable diseases and noncommunicable diseases, and with very few resources. Common clinical applications include teleconsultation, telecardiol-ogy (transmission of ECGs), teleradiology, and teledermatology. Many telehealth projects exist throughout Latin America and the Caribbean, Asia, and Africa, but there is little published evidence and only isolated examples of sustained programs, although several sustained humanitarian networks exist. Application of mobile solutions (m-health) is on the rise in many developing countries. Telehealth is still not integrated into existing health care systems globally. Reasons vary: lack of proven large-scale operations, poor evidence base, inadequate implementation, lack of attention to the “soft side” of implementation (readiness, change management), and many others. For the developing world, reasons can be more pragmatic, including limited resources, unreliable power, poor connectivity, and high cost for the poverty stricken – those most in need. Telehealth is poised to improve health and health care in the developing world, driven by both altruistic and profit motives. But to have the desired effect, telehealth must address very specific and evidence-based health “needs” of each facility, region, or country; the shortage of health workers and specialist services; and the required skills upgrading and training, allowing the developing world to establish its own critical mass of experts. This will only be achieved by raising awareness, understanding, and ability regarding telehealth capability and limitations, and by the coordinated political and professional will of all those involved to guide public and private innovation and telehealth integration.