Miracle-dz/UniFAR-FTUs huggingface dataset:
Inverse Correlation Between Heart Rate Recovery and Metabolic Risks in Healthy Children and Adolescents-Insight from the National Health and Nutrition Examination Survey 1999-2002

Objective: Heart rate recovery (HRR) is a marker for survival. Little is known about the association between HRR and metabolic risks in healthy children or adolescents. Research Design and Methods: We examined 993 healthy children and adolescents aged 12-19 years with reliable measures of cardiovascular fitness from Health and Nutrition Examination Survey 1999-2002. HRR parameters 1 to 3 minutes after exercise were calculated from exercise test results. Anthropometric and metabolic risk factors as well as metabolic z-score were obtained. Results: The HRR parameters were inversely correlated with most of the metabolic risks including WC, SBP, serum TG and serum CRP levels and were positively correlated with the serum HDL levels. In multiple linear regression analysis, among the metabolic risks, WC was the only parameter associated with HRR parameters ( p =0.038, 0.001 and 0.001 for 1 min-HRR, 2-min HRR and 3-min HRR respectively) in boys. In girls, WC ( p =0.001 and <0.001 for 2-min HRR and 3-min HRR respectively), SBP ( p =0.029 for 1-min HRR) and serum glucose levels ( p =0.021 for 2-min HRR) and serum CRP levels ( p =0.007 for 2-min HRR) were the most important determinants of HRR parameters. The adjusted 1-min HRR did not change across 4 quartiles of metabolic-z score while the adjusted 3-min HRR decreased significantly with 4 quartiles of metabolic z-score. Conclusions: Metabolic risks are inversely associated with HRR in healthy children and adolescents. Our finding suggests that the linkage between metabolic risks and autonomic nervous system functions in healthy young ages.
Validation of a fornix depth measurer: a putative tool for the assessment of progressive cicatrising conjunctivitis

Background/aims Documentation of conjunctival forniceal foreshortening in cases of progressive cicatrising conjunctivitis (PCC) is important in ascertaining disease stage and progression. Lower fornix shortening is often documented subjectively or semi-objectively, whereas upper forniceal obliteration is seldom quantiﬁed. Although tools such as fornix depth measurers (FDMs) have been described, their designs limit upper fornix measurement. The purpose of this study was to custom-design a FDM to evaluate the upper fornix and to assess variability in gauging fornix depth. Methods A polymethylmethacrylate FDM was constructed using industry-standard jewellery computer software and machinery. Two observers undertook a prospective independent evaluation of central lower fornix depth in a heterogeneous cohort of patients with clinically normal and abnormal conjunctival fornices both subjectively and by using the FDM (in mm). Upper central fornix depth was also measured. Agreement was assessed using Bland e Altman plots. Results Fifty-one eyes were evaluated. There was 100% intraobserver agreement to within 1 mm for each observer for lower fornix measurement. The mean difference in fornix depth loss using the FDM between observer 1 and 2 was 1.19%, with 95% conﬁdence of agreement ( 6 2SD) of (cid:1) 15% to +20%. In total, 86% (44/51) of measurements taken by the two observers agreed to within 10% of total lower fornix depth (ie, 6 1 mm) versus only 63% (32/51) of the subjective measurements. Mean upper fornix difference was 0.57 mm, with 95% conﬁdence of agreement of between (cid:1) 2 and + 3 mm. Conclusions This custom-designed FDM is well tolerated by patients and shows low intraobserver and interobserver variability. This enables repeatable and reproducible measurement of upper and lower fornix depths, facilitating improved rates of detection and better monitoring of progression of conjunctival scarring.
Severe symptomatic primary HCMV infection despite effective 1 innate and adaptive immune responses 2

26 Primary human cytomegalovirus (HCMV) infection usually goes unnoticed, causing mild or 27 no symptoms in immunocompetent individuals. Some rare severe clinical cases have however 28 been reported without investigation of host immune responses or viral virulence. In this 29 present study, we investigate, for the first time, phenotypic and functional features together 30 with gene expression profiles in immunocompetent adults experiencing a severe primary 31 HCMV infection. Twenty PHIP were enrolled as well as 26 HCMV-seronegative and 39 32 HCMV-seropositive healthy controls. PHIP had a huge lymphocytosis marked by massive 33 expansion of NK and T cell compartments. Interestingly, PHIP mounted efficient innate and 34 adaptive immune responses with a deep HCMV imprint, revealed mainly by the expansion of 35 NKG2C + NK cells, CD16 + V δ 2- γδ T cells and conventional HCMV-specific CD8 + T cells. 36 The main effector lymphocytes were activated and displayed an early immune phenotype that 37 developed toward a more mature differentiated status. We suggest that both huge 38 lymphocytosis and excessive lymphocyte activation could contribute to a massive cytokine 39 production known to mediate tissue damage observed in PHIP. Taken together, these findings 40 bring new insights into the comprehensive understanding of immune mechanisms involved 41 during primary HCMV-infection in immunocompetent individuals. 42 43 44 45 46 of with a the numerous immune evasion strategies employed by HCMV, host immune responses 118 mounted against primary HCMV infection are effective at controlling CMV replication and 119 dissemination. A broad literature on clinical cases has depicted severe symptoms associated 120 with primary HCMV infection in immunocompetent individuals without investigations on 121 host immune responses or HCMV virulence (20)(21). As both host and viral polymorphisms 122 may contribute to severe symptomatic HCMV infection, we focused our study on the cellular 123 immune responses from a rare cohort of immunocompetent patients undergoing severe 124 symptomatic primary HCMV infection. For this, we performed a broad phenotypic and 125 functional analysis of main lymphocyte subsets and characterized the gene expression profiles 126 from these patients. This study should provide new insights in the comprehensive 127 understanding of the immune responses in immunocompetent hosts undergoing acute primary 128 HCMV infection. cells or medium (negative control) to assess NK cell degranulation according to spontaneous lysis function. receptor positive P815 cell line pre-incubated with anti- CD16 (3G8; Beckman Coulter) or IgG1 (MOPC-21; BD Biosciences) control then co- cultured (effector:target ratio 1:1) with CD107a pre-incubated PBMCs to assess reverse ADCC function. of incubation, brefeldin block trans-Golgi transport intracellular accumulation permeabilized PE-conjugated anti-IFN these demonstrate a massive proliferation of NK cell compartment during symptomatic primary infection in immunocompetent adults with the early expression of and a
PREVENTION OF STATUS INCOMPATIBILITY IN FORCED RELOCATIONS: THE PUBLIC-MANAGEMENT ASPECT

The article deals with the relationship between the emergence of status incompatibility and internal migration processes. The peculiarities of the process of status incompatibility in Ukraine after the annexation of the Crimean peninsula and military operations on the territory of the Lugansk and Donetsk regions are investigated. Proposed measures to reduce the level of status incompatibility among internally displaced persons.
Chagas' Disease PATHOGENESIS OF THE ACUTE INFECTION: EXPERIMENTAL CONSIDERATIONS CLINICAL

INTRODUCTION . 400 LIFE CYCLE AND BIOLOGY. 400 Biochemistry of Differentiation . 400 Biochemistry of Invasion. 402 ACUTE CLINICAL CHAGAS' DISEASE . 403 PATHOGENESIS OF THE ACUTE INFECTION: EXPERIMENTAL CONSIDERATIONS.403 Animal Studies . 403 In Vitro Studies . 403 Immune Mechanisms . 404 Parasite Biochemistry. 404 CHRONIC CHAGAS' CARDIOMYOPATHY: CLINICAL AND PATHOLOGICAL ASPECTS . 404 Clinical Studies. 405 AUTONOMIC NERVOUS SYSTEM IN CHAGAS' DISEASE . 406 MICROVASCULAR ETIOLOGY OF CHRONIC CHAGAS' CARDIOMYOPATHY.406 AUTOIMMUNE ASPECTS OF CHAGAS' HEART DISEASE . 406 PATHOGENESIS OF NEUROLOGICAL MANIFESTATIONS . 407 CHRONIC GASTROINTESTINAL DISEASE. 407 Colon . 407 Esophagus . 408 Stomach . 409 Small Intestine. 409 Gallbladder. 409 DIAGNOSIS . 409 TREATMENT. 411 TRANSFUSION-ASSOCIATED TRANSMISSION OF T. CRUZlINFECTION.411 IMMUNOSUPPRESSION AND TRANSPLANTATION . 411 CONCLUSION. 412 ACKNOWLEDGMENTS. 412 REFERENCES . 412
Generalization Bias in Science

Many scientists routinely generalize from study samples to larger populations. It is commonly assumed that this cognitive process of scientific induction is a voluntary inference in which researchers assess the generalizability of their data and then draw conclusions accordingly. We challenge this view and argue for a novel account. The account describes scientific induction as involving by default a generalization bias that operates automatically and frequently leads researchers to unintentionally generalize their findings without sufficient evidence. The result is unwarranted, overgeneralized conclusions. We support this account of scientific induction by integrating a range of disparate findings from across the cognitive sciences that have until now not been connected to research on the nature of scientific induction. The view that scientific induction involves by default a generalization bias calls for a revision of the current thinking about scientific induction and highlights an overlooked cause of the replication crisis in the sciences. Commonly proposed interventions to tackle scientific overgeneralizations that may feed into this crisis need to be supplemented with cognitive debiasing strategies against generalization bias to most effectively improve science.
Prolegomenon to a Theory of Argument Structure

This work is the culmination of an eighteen-year collaboration between Ken Hale and Samuel Jay Keyser on the study of the syntax of lexical items. It examines the hypothesis that the behavior of lexical items may be explained in terms of a very small number of very simple principles. In particular, a lexical item is assumed to project a syntactic configuration defined over just two relations, complement and specifier, where these configurations are constrained to preclude iteration and to permit only binary branching. The work examines this hypothesis by methodically looking at a variety of constructions in English and other languages.
rearrangement of the receptor amino-terminal domain during activation and allosteric modulation.

N-Methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors essential for synaptic plasticity and memory. Receptor activation involves glycine- and glutamate-stabilized closure of the GluN1 and GluN2 subunit ligand binding domains that is allosterically regulated by the amino-terminal domain (ATD). Using single molecule ﬂ uorescence resonance energy transfer (smFRET) to monitor subunit rearrangements in real-time, we observe a stable ATD inter-dimer distance in the Apo state and test the effects of agonists and antagonists. We ﬁ nd that GluN1 and GluN2 have distinct gating functions. Glutamate binding to GluN2 subunits elicits two identical, sequential steps of ATD dimer separation. Glycine binding to GluN1 has no detectable effect, but unlocks the receptor for activation so that glycine and glutamate together drive an altered activation trajectory that is consistent with ATD dimer separation and rotation. We ﬁ nd that protons exert allosteric inhibition by sup-pressing the glutamate-driven ATD separation steps, and that greater ATD separation translates into greater rotation and higher open probability. glycine-binding site glycine glutamate point (H486A) GluN2B glutamate-binding site decreases glutamate af nity 1. 6µM to 0.52 mM) no signi ﬁ cant difference between FRET histograms obtained in the and absence of glutamate glycine-binding site was blocked by CGP glycine binding vented SNAP_GluN1-1a(F484A) 4b). there a difference in FRET histograms between wild-type SNAP_GluN1-1a/GluN2B in the of added glutamate and with glycine- binding site blocked by CGP corresponds and the combined GluN1 and GluN2 af ﬁ nity site mutations SNAP_- GluN1-1a(F484A)/GluN2B(H486A) 4b). These observations show that we the in zero-added glutamate and 3µM CGP.
Institutional Knowledge at Singapore Management University Institutional Knowledge at Singapore Management University Semi-universal portfolios with transaction costs Semi-universal portfolios with transaction costs

Online portfolio selection (PS) has been extensively studied in artiﬁcial intelligence and machine learning communities in recent years. An important practical issue of online PS is transaction cost, which is unavoidable and nontrivial in real ﬁnancial trading markets. Most existing strategies, such as universal portfolio (UP) based strategies, often rebalance their target portfolio vectors at every investment period, and thus the total transaction cost increases rapidly and the ﬁnal cumulative wealth degrades severely. To overcome the limita-tion, in this paper we investigate new investment strategies that rebalances its portfolio only at some selected instants. Speciﬁcally, we design a novel on-line PS strategy named semi-universal portfolio (SUP) strategy under transaction cost, which attempts to avoid rebalancing when the transaction cost outweighs the beneﬁt of trading. We show that the proposed SUP strategy is universal and has an upper bound on the regret. We present an efﬁcient implementation of the strategy based on non-uniform random walks and online factor graph algorithms. Empirical simulation on real historical markets show that SUP can overcome the draw-back of existing UP based transaction cost aware algorithms and achieve signiﬁcantly better performance.
(2016). Urodynamic function during sleep-like brain states in urethane anesthetized rats. Neuroscience 73-82.

—The aim was to investigate urodynamic parame- ters and functional excitability of the periaqueductal gray matter (PAG) during changes in sleep-like brain states in urethane anesthetized rats. Simultaneous recordings of detrusor pressure, external urethral sphincter (EUS) elec- tromyogram (EMG), cortical electroencephalogram (EEG), and single-unit activity in the PAG were made during repeated voiding induced by continuous infusion of saline into the bladder. The EEG cycled between synchronized, high-amplitude slow wave activity (SWA) and desynchronized low-amplitude fast activity similar to slow wave and ‘activated’ sleep-like brain states. During (SWA, 0.5–1.5 Hz synchronized oscillation of the EEG waveform) voiding became more irregular than in the ‘activated’ brain state (2–5 Hz low-amplitude desynchronized EEG waveform) and detrusor void pressure threshold, void volume threshold and the duration of bursting activity in the external urethral sphincter EMG were raised. The spontaneous ﬁring rate of 23/52 neurons recorded within the caudal PAG and adjacent tegmentum was linked to the EEG state, with the majority of responsive cells (92%) ﬁring more slowly during SWA. Almost a quarter of the cells recorded (12/52) showed phasic changes in ﬁring rate that were linked to the occurrence of voids. Inhibition ( n = 6), excitation ( n = 4) or excitation/inhi-bition ( n = 2) was seen. The spontaneous ﬁring rate of 83% of the micturition-responsive cells was sensitive to changes in EEG state. In nine of the 12 responsive cells (75%) the responses were reduced during SWA. We propose that during diﬀerent sleep-like brain states changes in urodynamic properties occur which may be linked to changing excitability of the micturition
Security Hardening dengan Cloud Web Service untuk Pengamanan Website Berbasis Wordpress

Perkembangan jumlah website dari tahun ke tahun selalu meningkat. Salah satu CMS yang paling banyak digunakan untuk mengembangkan website adalah Wordpress. Banyaknya pengguna Wordpress membuat hacker tertarik untuk mengeksploitasi celah keamanan pada Wordpress. Jumlah website berbasis Wordpress yang diretas setiap tahunnya selalu meningkat. Hal ini sangat merepotkan para pengelola website, terutama bagi mereka yang mengelola lebih dari satu website yang harus memperbaiki websitenya satu persatu. Untuk mengatasi hal tersebut, dibuatlah suatu metode keamanan yang memungkinkan para pengelola website tersebut untuk lebih mudah melakukan keempat tahapan security hardening yaitu Access, Analyze, Remediate, dan Manage guna mengamankan websitenya dari satu tempat terintegrasi dengan memanfaatkan aplikasi keamanan berbasis cloud. Berdasarkan survei pengguna, aplikasi ini berhasil mempermudah dan mempersingkat waktu pengguna dalam melakukan pengamanan pada website.
NVMe Solid State Storage Performance Testing

—The paper presents the initial stage of constructing a performance model of a modern solid-state drive with a PCIe NVMe interface – a methodology for collecting performance data for existing devices, on the basis of which the model will be built. Approach, implementation and results of implementation of presented methodology are presented. An open source utility is proposed for creating a public NVMe SSD performance data set.
An Anhydro- N -Acetylmuramyl- L -Alanine Amidase with Broad Speciﬁcity Tethered to the Outer Membrane of Escherichia coli (cid:1)

From its amino acid sequence homology with AmpD, we recognized YbjR, now renamed AmiD, as a possible second 1,6-anhydro- N -acetylmuramic acid (anhMurNAc)- L -alanine amidase in Escherichia coli . We have now conﬁrmed that AmiD is an anhMurNAc- L -Ala amidase and demonstrated that AmpD and AmiD are the only enzymes present in E. coli that are able to cleave the anhMurNAc- L -Ala bond. The activity was present only in the outer membrane fraction obtained from an ampD mutant. In contrast to AmpD, which is speciﬁc for the anhMurNAc- L -alanine bond, AmiD also cleaved the bond between MurNAc and L -alanine in both muropep- tides and murein sacculi. Unlike the periplasmic murein amidases, AmiD did not participate in cell separation. ampG mutants, which are unable to import GlcNAc-anhMurNAc-peptides into the cytoplasm, released mainly peptides into the medium due to AmiD activity, whereas an ampG amiD double mutant released a large amount of intact GlcNAc-anhMurNAc-peptides into the medium. During growth, 40 to 50% of the Escherichia coli murein (pep-tidoglycan) is broken down and reused each generation. This is sufﬁcient to provide 25% of the murein in the daughter cells. During the for 10 min at room temperature), the soluble components were separated by HPLC with the triﬂuoroacetic acid solvent system. The products were detected by their UV absorbances at 206 nm. The three main fractions were recovered, lyophilized, and identiﬁed by mass spectrometry with a Voyager DE Pro matrix-assisted laser desorption ionization—time-of-ﬂight (MALDI-TOF) mass spec- trometer (Applied Biosystems, Foster City, CA) at the Tufts Core Facility. cleave whole-cell cytoplasm, periplasm, and envelopes TP78B TP78BD were incubated at 37°C with [ 3 H]Dap-labeled GlcNAc-anhMurNAc-tripeptide, followed by analysis using HPLC. As 1, the whole-cell extract from TP78BD totally lacked activity to release the tripeptide from the substrate, while that from TP78B cleaved 22% of the substrate. These results indicate that AmiD is the only anhMurNAc- L -Ala amidase in the ampD mutant.
Ableitung von Versiegelungsgraden basierend auf hochaufgelösten Fernerkundungsdaten mittels „Support Vector Regression“

In Deutschland findet eine stetig fortschreitende Zersiedelung der Landschaft und damit eine konstant hohe Flacheninanspruchnahme statt. Zur statistischen Erfassung steht jedoch neben der amtlich erfassten Kennzahl „Siedlungsund Verkehrsflache“ (SuV), welche fur eine quantitative und qualitative Bewertung der Flacheninanspruchnahme ungenugend ist, kein validiertes Bilanzierungssystem zu Verfugung. In diesem Beitrag wird der „Impervious Surface Analyst“ (iSurf-A) zur fernerkundlichen Ableitung von Versiegelungsgraden mittels „Support Vector Machines“ (SVM) vorgestellt. Die Anwendung dieser Versiegelungsanalysen wurde anhand von digitalen Luftbildern sowie Ikonos Satellitenaufnahmen am Beispiel der Stadt Leipzig demonstriert und validiert. Eine Uberprufung der Versiegelungsergebnisse zeigt vielversprechende Gesamtgenauigkeiten von bis zu 89 %. Die vorgestellte Methodik ermoglicht somit die Lucke der Flachenstatistik zu schliesen.
Spatial Analysis of Malaria Incidence Rates Use of Generalized Linear Mixed Models in the Spatial Analysis of Small-Area Malaria Incidence Rates in KwaZulu Natal, South Africa

1 Spatial statistical analysis of 1994–1995 small-area malaria incidence rates in the population of the northernmost districts of KwaZulu Natal, South Africa, was undertaken to identify factors that might explain very strong heterogeneity in the rates. In this paper, the authors describe a method of adjusting the regression analysis results for strong spatial correlation in the rates by using generalized linear mixed models and variograms.The results of the spatially adjusted, multiple regression analysis showed that malaria incidence was significantly positively associated with higher winter rainfall and a higher average maximum temperature and was significantly negatively associated with increasing distance from water bodies. The statistical model was used to produce a map of predicted malaria incidence in the area, taking into account local variation from the model prediction if this variation was supported by the data. The predictor variables showed that even small differences in climate can have very marked effects on the intensity of malaria transmission, even in areas subject to malaria control for many years.The results of this study have important implications for malaria control programs in the area. Am J Epidemiol 2001;153:1213–21. The
International Journal of Science and Business

Entrepreneurship is the dynamic process of generating, planning and building something original with value by bestowing the essential moment in time and attempt, assuming the associated psychical, output, innovation and employment, social risks, fiscal and getting the resulting rewards of commercial and personal satisfaction and freedom. The paper has been undertaken with an objective to examine the women entrepreneurship in Bangladesh: influential factors of women participation in SMEs area. Several factors are forceful tool to influence women participation in SMEs area. The paper examines financial, technological, psychological, hard work, business plan, knowledge & skills, family, sociocultural, security, training programs, administrative, taxation, regulatory, geographical, political condition that affect women participation in SMEs area. The data is collected from 270 women entrepreneur by survey method through a structured questionnaire with five-point Likert scales & multiple items. Convenience sampling technique is applied. Data are analyzed using frequency analysis, factors analysis, and regression analysis. Thus, the factor analysis may be considered an approximate technique for analyzing the data. Using varimax rotation, reducing the 15 variables, the study has acquired 5 uncorrelated factors having Eigen value greater than 1. Those factors like training programs factors, financial factors, technological factors, knowledge & skills factors, family factors. From the outcomes of regression analysis, the research is found that training programs factors, financial factors, technological factors, and family factors as the vigorous features, which effect on women participation in SMEs area. The consequences of this study may be used by government and nongovernment area, rural development academy, policymakers and even investigators to stimulate women participation in SMEs area in Bangladesh. IJSB Accepted 27 April 2019 Published 28 April 2019 DOI: 10.5281/zenodo.2652989