Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing vaccine hesitancy and health literacy using a new Italian vaccine confidence index and a modified Italian medical term recognition test: A cross-sectional survey on Italian parents

ABSTRACT The decline in children’s vaccination coverage and the resurgence of preventable infectious diseases draw attention to parents’ vaccine hesitancy. Our study introduces two validated tools to independently assess vaccine hesitancy and health literacy among parents with school-age children. We developed a Vaccine Confidence Index (VCI) from 10 Likert items, exploring their relationships through exploratory and confirmatory factor analyses. We modified the IMETER (Italian medical term recognition test) to measure health literacy. We assessed the internal consistency of the modified IMETER and the 10 Likert items using Cronbach’s alpha test (α) and McDonald’s omega total coefficient (ω) with good results (ω = 0.92, α = 0.90; ω = 0.87, α = 0.82 respectively). We used these tools within a questionnaire conducted on 743 parents recruited from pediatric clinic waiting rooms in Italy, collecting demographic data, information sources on vaccines and vaccine-preventable diseases knowledge. The VCI resulting from factor analyses consisted of six items on a ten-point Likert scale, reflecting the ratio of positive to negative items. The survey revealed significant variations in the VCI according to individual features such as education, use of social networks, or Health institutions as sources of information. Multivariate logistic regression identified an association between vaccine intention and the VCI. Health literacy was functional for 91.2% of participants, but knowledge about vaccine-preventable diseases was generally low. The VCI showed no significant association with health literacy and vaccine-preventable diseases knowledge. The VCI and the modified IMETER effectively assess vaccination attitude and health literacy, offering valuable public health tools for tailoring vaccination campaigns to hesitant population subgroups.
DNMT1 determines osteosarcoma cell resistance to apoptosis by associatively modulating DNA and mRNA cytosine‐5 methylation

Cellular apoptosis is a central mechanism leveraged by chemotherapy to treat human cancers. 5‐Methylcytosine (m5C) modifications installed on both DNA and mRNA are documented to regulate apoptosis independently. However, the interplay or crosstalk between them in cellular apoptosis has not yet been explored. Here, we reported that promoter methylation by DNMT1 coordinated with mRNA methylation by NSun2 to regulate osteosarcoma cell apoptosis. DNMT1 was induced during osteosarcoma cell apoptosis triggered by chemotherapeutic drugs, whereas NSun2 expression was suppressed. DNMT1 was found to repress NSun2 expression by methylating the NSun2 promoter. Moreover, DNMT1 and NSun2 regulate the anti‐apoptotic genes AXL, NOTCH2, and YAP1 through DNA and mRNA methylation, respectively. Upon exposure to cisplatin or doxorubicin, DNMT1 elevation drastically reduced the expression of these anti‐apoptotic genes via enhanced promoter methylation coupled with NSun2 ablation‐mediated attenuation of mRNA methylation, thus rendering osteosarcoma cells to apoptosis. Collectively, our findings establish crosstalk of importance between DNA and RNA cytosine methylations in determining osteosarcoma resistance to apoptosis during chemotherapy, shedding new light on future treatment of osteosarcoma, and adding additional layers to the control of gene expression at different epigenetic levels.
PHYTOTECHNOLOGY INSIGHT FOR THE FLOOD PLAINS ALONG THE RIVER AND RIPARIAN ZONE

The case study was presented with the purpose of obtaining quantitative landscape span along the river and riparian zone. Field observations carried out in many places in Indonesia and also studied the experiences of some countries, all of which were intended to avoid similar mistakes in the future. Approach on spans establishment of riparian areas was in perspective phytotechnology for environmental protection. River water quality and riverbanks stability were discussed. The general picture riparian span was 100m, 10 times the maximum depth of the river, 44m for every 1m overflow river. The riparian span need to be corrected by taking into account the local topographic slope of landscape.
Relationship between Yangzte riverway fractal and geological structure of the catchment

Self\|organized structure of Riverway has a typical multi\|fractal feature. It is hard to describe the local variety of riverway shape by traditional length method. The article introduced a continual iterative motion length method. According to the characteristic scale, mark off a set of nodes along the stretch direction of the riverway. Some nodes constitute a zone. The fractal dimensions of these zones were calculated and make the zone continual iterative motion along the nodes. Discrete fractal dimensions of each node in the whole riverway was finally obtained. The study indicated that there are close relations between the variety feature of the fractal dimension of Yangzte riverway showed by constant iterative motion length method and the structure evolution, geography, geologic factors of China continent.
Insights and expectations of healthcare professionals on the implementation of the updated pediatric regional immunization Calendar in Calabria, Italy

ABSTRACT The Regional Immunization Calendar in Calabria, a region of Italy, was updated in 2022, introducing optional co-administration of three injectable vaccines, with one oral vaccine, at 3 and 5 months old, and three injectable vaccines at 13–14 months old. In this project, the opinions and expectations of healthcare professionals (HCPs) in Calabria were investigated, with respect to the updated recommended practices. An 11-question survey was developed, which addressed concepts and topics related to immunization calendar implementation. Focus group discussions were also organized to provide further insight on the survey findings. A total of 132 HCPs completed the survey (86 public health providers [PHs] and 46 family pediatricians [FPs]). Overall, ≥50% of respondents agreed that vaccine co-administration would be advantageous for public health by reducing the number of vaccination sessions required. Most PHs and FPs agreed that dissemination of available safety data on vaccine co-administration is a necessary action to facilitate effective implementation of the strategy into clinical practice. The importance of safety data related to vaccine co-administration was supported further by discussions held in PH and FP focus groups. Overall, these findings demonstrate support from HCPs in Calabria for vaccine co-administration, and highlight key activities needed for successful uptake.
Association between rectal diameter and response to treatment with parasacral transcutaneous electrical nerve stimulation and behavioral changes in children and adolescents with bladder and bowel dysfunction

ABSTRACT Purpose: Parasacral Transcutaneous Electrical Stimulation (TENS) is one of the treatments for children with Bladder and Bowel Dysfunction (BBD). Some studies showed that children with increased Rectal Diameter (RD) have more Functional Constipation (FC). However, RD prediction in maintenance of BBD after treatment was never evaluated. Our aim is to evaluate the association between RD and response to treatment in children and adolescents with BBD. Materials and Methods: This study evaluated patients from 5-17 years old with BBD. Dysfunctional Voiding Scoring System (DVSS), Rome IV criteria, and the Constipation Score were used. RD was measured using abdominal ultrasound before treatment according to the technique established by Klijn et al. and was considered enlarged when >3cm. No laxatives were used during treatment. Descriptive analysis and binary regression were performed and the area under the ROC curve was calculated. Results: Forty children were included (mean age 8.4±2.8 years, 52.5% male). Before treatment, RD was enlarged in 15 children (37.5%) (mean diameter 3.84±0.6cm), with FC persisting post-treatment in 11/15(73.3%). Those patients also required more laxatives following treatment and had more severe FC. Binary regression showed pretreatment RD to be an independent predictor of the persistence of FC post-treatment (OR=9.56; 95%CI:2.05-44.60). In ROC curve analysis, the sensitivity was 100% (95%CI: 0.49-1.0) and specificity 77.14% (95%CI:0.60-0.90) for rectal diameter >3 cm. The likelihood ratio was 4.38 (95%CI:2.40-8.0) for the persistence of BBD following treatment. Conclusion: RD appears to be relevant in the evaluation of children with BBD, not only as a diagnostic tool but also as a predictor of treatment outcome.
Tuberculosis in Britain : its history and palaeoepidemiology

This paper considers the evidence for tuberculosis in skeletal samples from Britain dating from the Romano-British (c. 4 t h century AD) to the post-Medieval periods (after the 16 t h century AD). Distribution patterns for the evidence are considered followed by a consideration of the origin of tuberculosis in Britain and its palaeoepidemiology. General increases in frequency of tuberculosis through time are seen with a northern distribution trend developing from an initial south and east focus. The contribution of tuberculous animals to the infection load in humans, and the relationship of leprosy to tuberculosis are considered, with further work being recommended to clarify previous assumptions. Limitations of the data are discussed.
A Survey on the Coverage of WSNs

Wireless sensor networks address a broad range of applications related to national security, surveillance, military, healthcare and environmental monitoring. They are rapidly growing area for research and commercial development. One of the most active areas of research in wireless sensor networks is that of coverage. Coverage in wireless sensor networks is usually defined as extent or degree to which something is observed, analyzed, and reported. The coverage problem has been extensively studied in recent years. In this paper, we take a representative survey of the work that has been done in the area of coverage. Several terms and concepts have been defined and then shown how they are being utilized in various research works. We also provide a brief summary and comparison of different types of coverage.
MULTISENSOR Mining and Understanding of multilinguaL contenT for Intelligent Sentiment Enriched coNtext and Social Oriented inteRpretation FP 7-610411 D 4 . 1 Multimedia indexing and topic-based classification

Dissemination level: Public Contractual date of delivery: Month 12, 31/10/2014 Actual date of delivery: Month 12, 31/10/2014 Workpackage: WP4 Multidimensional content integration and retrieval Task: T4.1 Topic-based modelling T4.4 Multimodal indexing and retrieval Type: Report Approval Status: Final Draft Version: 1.0 Number of pages: 62 Filename: D4. 1_MultimediaIndexing_2014-10-31_v1.0.pdf Abstract The document describes the techniques for topic-based classification using supervised machine learning on top of a vector-based content representation. It also includes the presentation of a unified model for the representation of socially enriched multimedia.
T lymphocytes-related cell network in the pathogenesis of juvenile idiopathic arthritis: a key point for personalized treatment

Purpose of review Juvenile idiopathic arthritis (JIA) is a heterogeneous group of arthritis of unknown origin occurring in children under 16 years of age and persisting for at least 6 weeks. Given that JIA is an inflammatory disorder, treatment strategies, including also biologicals, are focused on suppressing excessive inflammation. The finding that different patients display different responses to biological drugs supports the concept that different pathogenic mechanisms can exist in JIA, with specific cellular and molecular mechanisms driving inflammation in each patient. The aim of this review is to highlight the most recent advances in understanding the role of immune cells in JIA pathogenesis. Recent findings This review encompasses the role of the different cell subsets involved in sustaining inflammation in JIA, with a particular emphasis on T cells, as they orchestrate both innate and adaptive auto-reactive immunity in affected joints. Summary The characterization of the cellular and molecular pathways supporting inflammation will be crucial to design novel therapeutic approaches in the context of personalized medicine.
Petersen estimator, Chapman adjustment, list effects, and heterogeneity

We use a nonparametric mixture model for the purpose of estimating the size of a population from multiple lists in which both the individual effects and list effects are allowed to vary. We propose a lower bound of the population size that admits an analytic expression. The lower bound can be estimated without the necessity of model‐fitting. The asymptotical normality of the estimator is established. Both the estimator itself and that for the estimable bound of its variance are adjusted. These adjusted versions are shown to be unbiased in the limit. Simulation experiments are performed to assess the proposed approach and real applications are studied.
Evidence for grain growth in T Tauri disks

In this article we present the results from mid-infrared spectroscopy of a sample of 14 T Tauri stars with silicate emission. The qualitative analysis of the spectra reveals a correlation between the strength of the silicate feature and its shape similar to the one which was found recently for the more massive Herbig Ae/Be stars by van Boekel et al. (2003). The comparison with theoretical spectra of amorphous olivine ([Mg,Fe] 2 SiO 4 ) with different grain sizes suggests that this correlation is indicating grain growth in the disks of TTauri stars. Similar mechanisms of grain processing appear to be effective in both groups of young stars.
Di- and Tri- but Not Monomethylation on Histone H3 Lysine 36 Marks Active Transcription of Genes Involved in Flowering Time Regulation and Other Processes in Arabidopsis thaliana

ABSTRACT Histone lysines can be mono-, di-, or trimethylated, providing an ample magnitude of epigenetic information for transcription regulation. In fungi, SET2 is the sole methyltransferase responsible for mono-, di-, and trimethylation of H3K36. Here we show that in Arabidopsis thaliana, the degree of H3K36 methylation is regulated by distinct methyltransferases. The SET2 homologs SDG8 and SDG26 each can methylate oligonucleosomes in vitro, and both proteins are localized in the nucleus. While the previously reported loss-of-function sdg8 mutants have an early-flowering phenotype, the loss-of-function sdg26 mutants show a late-flowering phenotype. Consistently, several MADS-box flowering repressors are down-regulated by sdg8 but up-regulated by sdg26. The sdg8 but not the sdg26 mutant plants show a dramatically reduced level of both di- and trimethyl-H3K36 and an increased level of monomethyl-H3K36. SDG8 is thus specifically required for di- and trimethylation of H3K36. Our results further establish that H3K36 di- and tri- but not monomethylation correlates with transcription activation. Finally, we show that SDG8 and VIP4, which encodes a component of the PAF1 complex, act independently and synergistically in transcription regulation. Together our results reveal that the deposition of H3K36 methylation is finely regulated, possibly to cope with the complex regulation of growth and development in higher eukaryotes.
Mini Review Article

The long non-coding RNAs: a new (p)layer in the " dark matter " The transcriptome of a cell is represented by a myriad of different RNA molecules with and without protein-coding capacities. In recent years, advances in sequencing technologies have allowed researchers to more fully appreciate the complexity of whole transcriptomes, showing that the vast majority of the genome is transcribed, producing a diverse population of non-protein coding RNAs (ncRNAs). Thus, the biological significance of non-coding RNAs (ncRNAs) have been largely underestimated. Amongst these multiple classes of ncRNAs, the long non-coding RNAs (lncRNAs) are apparently the most numerous and functionally diverse. A small but growing number of lncRNAs have been experimentally studied, and a view is emerging that these are key regulators of epigenetic gene regulation in mam-malian cells. LncRNAs have already been implicated in human diseases such as cancer and neurodegeneration, highlighting the importance of this emergent field. In this article, we review the catalogs of annotated lncRNAs and the latest advances in our understanding of lncRNAs. Some of the most fundamental cellular processes rely on anciently conserved non-coding RNAs (ncRNAs). These include, for instance, the ribosomal RNAs which are assembled together to constitute ribosomes, the factories for translation of messenger RNAs (mRNAs) into proteins. Other ancient roles of ncRNAs include the transport of amino acids through ribosomes via the transfer RNAs (tRNAs) or the splicing of introns of pre-mRNA which is mediated in part by the snRNAs (small nuclear RNAs). More recently, the crucial role of ncRNA in post-transcriptional gene regulation has been highlighted by the discovery of microR-NAs (miRNAs), which repress gene expression by targeting semi-complementary motifs in target mRNAs (Lee et al., 1993). Many additional classes of ncRNAs have been discovered in the last decade reinforcing the view that they are of central importance in the functioning of cells from all the branches of life (Amaral et al., 2008). Amongst the various ncRNA classes, we know probably least about the long non-coding RNAs (lncRNAs). In particular, what is the total number of lncRNAs in mammalian genomes? Where are they localized? What is their significance in the context of evolution , and particularly in the evolution of complex processing in primate brains? Now that good catalogs of lncRNAs have become available, the most critical question is to address the functional-ity of these transcripts. This question is particularly acute given that we have no a priori methods for the …
Coordinated beamforming in cellular and cognitive radio networks

This thesis focuses on the design of coordinated downlink beamforming techniques for wireless multi-cell multi-user multi-antenna systems. In particular, cellular and cognitive radio networks are considered. In general, coordinated beamforming schemes aim to improve system performance, especially at the cell-edge area, by controlling inter-cell interference. In this work, special emphasis is put on practical coordinated beamforming designs that can be implemented in a decentralized manner by relying on local channel state information (CSI) and low-rate backhaul signaling. The network design objective is the sum power minimization (SPMin) of base stations (BSs) while providing the guaranteed minimum rate for each user. Decentralized coordinated beamforming techniques are developed for cellular multi-user multiple-input single-output (MISO) systems. The proposed iterative algorithms are based on classical primal and dual decomposition methods. The SPMin problem is decomposed into two optimization levels, i.e., BS-specific subproblems for the beamforming design and a network-wide master problem for the inter-cell interference coordination. After the acquisition of local CSI, each BS can independently compute its transmit beamformers by solving the subproblem via standard convex optimization techniques. Interference coordination is managed by solving the master problem via a traditional subgradient method that requires scalar information exchange between the BSs. The algorithms make it possible to satisfy the user-specific rate constraints for any iteration. Hence, delay and signaling overhead can be reduced by limiting the number of performed iterations. In this respect, the proposed algorithms are applicable to practical implementations unlike most of the existing decentralized approaches. The numerical results demonstrate that the algorithms provide significant performance gains over zero-forcing beamforming strategies. Coordinated beamforming is also studied in cellular multi-user multiple-input multiple-output (MIMO) systems. The corresponding non-convex SPMin problem is divided into transmit and receive beamforming optimization steps that are alternately solved via successive convex approximation method and the linear minimum mean square error criterion, respectively, until the desired level of convergence is attained. In addition to centralized design, two decentralized primal decomposition-based algorithms are proposed wherein the transmit and receive beamforming designs are facilitated by a combination of pilot and backhaul signaling. The results show that the proposed MIMO algorithms notably outperform the MISO ones. Finally, cellular coordinated beamforming strategies are extended to multi-user MISO cognitive radio systems, where primary and secondary networks share the same spectrum. Here, network optimization is performed for the secondary system with additional interference constraints imposed for the primary users. Decentralized algorithms are proposed based on primal decomposition and an alternating direction method of multipliers.
How local re-interpretation of American management techniques reveals the socio-cultural context of enterprising: The Tunisian case of Poulina

Drawing upon the case of Poulina-a Tunisian company that has implemented American management techniquesthis paper aims to improve our understanding of management modernisation‘ challenges in developing countries. It advocates that it is incoherent to impose to developing countries to adopt a unique model of management. Such scheme does not respect the local cultural specificities and ignore the opportunities that they can bring. The case provides an illustration of the importance of providing local and legitimate meanings to the imported techniques to make their implementation successful in developing countries 2 .
Nonparametric Statistics

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