Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular Mechanisms of AMPA Receptor Trafficking in the Nervous System

Synaptic plasticity enhances or reduces connections between neurons, affecting learning and memory. Postsynaptic AMPARs mediate greater than 90% of the rapid excitatory synaptic transmission in glutamatergic neurons. The number and subunit composition of AMPARs are fundamental to synaptic plasticity and the formation of entire neural networks. Accordingly, the insertion and functionalization of AMPARs at the postsynaptic membrane have become a core issue related to neural circuit formation and information processing in the central nervous system. In this review, we summarize current knowledge regarding the related mechanisms of AMPAR expression and trafficking. The proteins related to AMPAR trafficking are discussed in detail, including vesicle-related proteins, cytoskeletal proteins, synaptic proteins, and protein kinases. Furthermore, significant emphasis was placed on the pivotal role of the actin cytoskeleton, which spans throughout the entire transport process in AMPAR transport, indicating that the actin cytoskeleton may serve as a fundamental basis for AMPAR trafficking. Additionally, we summarize the proteases involved in AMPAR post-translational modifications. Moreover, we provide an overview of AMPAR transport and localization to the postsynaptic membrane. Understanding the assembly, trafficking, and dynamic synaptic expression mechanisms of AMPAR may provide valuable insights into the cognitive decline associated with neurodegenerative diseases.
The influence of drought on Neochanna apoda metapopulation persistence under global warming and land-use change.

5 Chapter One: General introduction . 7 Chapter Two: Trap-shyness subsidence is a threshold function of mark-recapture interval in brown mudfish Neochanna apoda populations Abstract . 16 Introduction . 17 Methods. 19 Results . 26 Discussion . 33 Chapter Three: Drought-survival is a threshold function of habitat size and population density in a fish metapopulation Abstract . 36 Introduction . 37 Methods. 38 Results . 44 Discussion . 50 Chapter Four: The scaling of population persistence with carrying capacity does not asymptote in fish populations experiencing extreme climate variability Abstract . 54 Introduction . 55 Methods. 57 Results . 67 Discussion . 71
Dynamic Event-Triggered Control for Persistent Dwell-Time Switched Nonlinear Multiagent Systems With Random Packet Loss

In this article, the dynamic event-triggered control scheme is given to achieve the consensus of a class of nonlinear multiagent systems with switching topologies and random packet loss. Different from the existing works of modeling topology switching in a random way, the persistent dwell-time switching rule is utilized to depict the scenario of topology alterations. To cope with the problem of redundant data transmission, the information interaction between neighboring agents is determined by the up-front design triggering condition. Instead of the conventional static threshold parameter (TP) in the triggering condition, the TP in this article can be adjusted dynamically. This means that the update frequency of the controller can be further optimized. The imperfect matching phenomenon between premise variables about the fuzzy system and controller is also tackled. Moreover, in theory, the packet loss is modeled as a Markov process. Eventually, an application example about the truck-trailer model is presented to express the practicability of the proposed method.
immunostimulatory effects of the standardized extract of Tinospora crispa on innate immune responses in Wistar Kyoto rats

: Tinospora crispa (TC) has been used in folkloric medicine for the treatment of various diseases and has been reported for several pharmacological activities. However, the effects of TC extract on the immune system are largely unknown. Therefore, the present study was aimed to investigate the immunomodulatory effects of a standardized 80% ethanol extract of the stem of TC on innate immune responses. Male Wistar Kyoto rats were treated daily at 100 mg/kg, 200 mg/kg, and 400 mg/kg doses of the extract for 21 days by oral gavage. The immunomodulatory potential of TC was evaluated by determining its effect on chemotaxis and phagocytic activity of neutrophils isolated from the blood of rats. To further elucidate the mechanism of action, its effects on the proliferation of T-and B-lymphocytes and T-lymphocytes subsets (CD4 + and CD8 + ) and on the secretion of Th1 and Th2 cytokines were also monitored. The main components of the extracts, syringin and magnoflorine, were identified and quantitatively analyzed in the extracts by using a validated reversed-phase high-performance liquid chromatography method. It was observed that the chemotactic activity of neutrophils obtained from extract-treated rats increased as compared to controls. A dose-dependent increase in the number of migrated cells and phagocytosis activity of neutrophils was observed. Dose-dependent increase was also observed in the T-and B-lymphocytes proliferation stimulated with concanavalin A (5 μ g/mL) and lipopolysaccharide (10 μ g/mL), and was statistically significant at 400 mg/kg ( P  0.01). Apart from cell-mediated immune response, the concentrations of Th1 (TNF-α , IL-2, and IFN-γ ) and Th2 (IL-4) cytokines were significantly increased in sera of rats treated with different doses as compared with the control group. From these findings, it can be concluded that TC possesses immunostimulatory activity and has therapeutic potential for the prevention of immune diseases.
Can We Do Better Next Time? Italians’ Response to Can We Do Better Next Time? Italians’ Response to the COVID-19 Emergency through a Heuristics and the COVID-19 Emergency through a Heuristics and Biases Lens Biases Lens

: During the outbreak of COVID-19 in Italy, people often failed to adopt behaviors that could have stopped, or at least slowed down, the spread of this deadly disease. We offer cognitive explanations for these decisions, based on some of the most common heuristics and biases that are known to inﬂuence human judgment and decision-making, especially under conditions of high uncertainty. Our analysis concludes with the following recommendations: policymakers can and should take advantage of this established science, in order to communicate more effectively and increase the likelihood that people choose responsible actions in a public health crisis.
Acute Effects of Low Intensity Resistance Exercise on State Body Image and Affective States in Men with and without Symptoms of Muscle Dysmorphia

Acute Effects of Low Intensity Resistance Exercise on State Body Image and Affective States in Men with and without Symptoms of Muscle Dysmorphia. SportRχiv Abstract Background: A hallmark characteristic of people with muscle dysmorphia (MD) is daily bouts of vigorous resistance exercise (RE). Moreover, these people experience significant tension and distress when forced to miss (i
Urban Responses to Climate Change: Theories and Governance Urban Responses to Climate Change: Theories and Governance Practice in Cities of the Global South Practice in Cities of the Global South

Cities around the world have recently started to become ‘proactive’ initiators of climate strategies containing both mitigation and adaptation elements. The experience of these ﬁrst movers has been studied and documented both empirically and, to a lesser extent, theoretically, primarily for cities in the global North. This symposium addresses related knowledge gaps by exploring case studies of urban regions in the global South confronting their projected climate change challenges, showcasing the experiences of Delhi, Santiago de Chile and Bogotá. Its speciﬁc aim is to explore the urban social response to nature change, the adaptation challenges faced by cities across the world and current practices of urban adaptation. Further, the symposium seeks to understand to what extent and in what respect current conceptual frameworks — which highlight urban ecological security and vulnerability — provide a useful context/framing to assist cities in confronting their challenges and to explain their actions. This introductory article examines current knowledge of the theory and practice of urban climate response. It introduces the concepts of ecological security and vulnerability and discusses the adaptive capacity of cities and how they are starting to respond to the emerging challenges of climate change. It concludes with a synthesis of the case articles and highlights some of the ﬁndings.
Identification of Peking duck breed based on hyperspectral imaging with machine learning

Peking duck, an EU-China mutual geographical indication protected product, is vulnerable to counterfeiting due to its widespread popularity and high profit. Efficient and intelligent breed identification is becoming more and more important to protect interests of stakeholders along the Peking duck supply chain, as well as the reputation of Peking duck. 160 hyperspectral images from Peking duck and Cherry Valley duck breeds are collected and divided into training and verification datasets in a 3:1 ratio after extracting texture features by PCA and GLCM. SVM with polynomial and radial basis kernel functions, as well as BP neural network models are established to identify duck breeds. Results show the SVM model with radial basis kernel function performs the best with an identification accuracy of 94.17%, and further validation achieving a satisfactory identification accuracy of 95%.
Permutation Tests for Label Ranking

In recent years, many Label Ranking (LR) methods have been proposed, along with an increasing number of datasets. The validation of these algorithms has been done empirically, as is usual in Machine Learning, by testing them on a set of benchmark datasets. Due to the scarcity of real-world LR data, most of the experiments are based on LR datasets that were adapted from classiﬁcation and regression datasets from the UCI repository and Statlog project. In this work, we want to test how strong is the relation between the target rankings and independent variables. In other supervised learning tasks, target swap randomization methods have been used to test it. We propose two target swap randomization approaches for LR and apply them on KEBI datasets. Our results show that there are meaningful relations between the independent variables and the target rankings and that the relative importance of each label in a ranking varies in some cases.
ScholarWorks@UARK ScholarWorks@UARK

Fruit and vegetable consumption is particularly low in Arkansas with only a small percentage of residents meeting daily recommendations. Arkansas also has one of the highest percentages of food insecurity and obesity in the United States. Low-income households, such as Supplemental Nutrition Assistance Program (SNAP) recipients, are at a higher risk of these issues. Financial assistance programs have been implemented to help in aiding these problems. The Double Up Food Bucks program (DUFB) is one of these programs. DUFB provides matching financial vouchers for SNAP benefits recipients spend on fresh local produce at participating grocery stores and farmers’ markets. The goal of this program is to help SNAP recipients increase fruit and vegetable consumption. Previous studies have examined DUFB and similar programs; however, few have studied how these programs affect the participating locations. One objective of this study is to analyze the effect DUFB has on produce sales at grocery stores. Objective two is to conduct a simulation of the overall revenue produced by DUFB at farmers’ markets. Store-level sales data was collected at three comparable sized stores with one serving as the treated and the others as controls in February 2016 and 2017. A difference-in-difference (DID) model was utilized to evaluate the effect of DUFB on sales after treatment for selected produce. For objective two, a demand shock caused by DUFB was simulated on various supply systems. DUFB was found to increases sales and quantity at the treated store as well as generate positive revenue in each system. DUFB increased sales for almost each tested produce. DUFB generated on average about $1.66 in revenue for each dollar of funding. Our evaluation indicates that DUFB was successful and can continue to be successful. Additional funding could see increased revenue for participating locations. Policy
Age, not Autism, Inﬂuences Multisensory Integration of Speech Stimuli among Adults

Diﬀerences between autistic and non-autistic individuals in perception of the temporal relationships between sights and sounds are theorized to underlie diﬃculties in integrating relevant sensory information. These, in turn, are thought to contribute to problems with speech perception and higher level social behaviors. However, the literature establishing this connection often involves limited sample sizes and focuses almost entirely on children. To determine whether these diﬀerences persist into adulthood, we compared 469 autistic and 373 non-autistic adults (aged 17 to 75 years). Participants completed an online version of the McGurk/MacDonald paradigm, a multisensory illusion indicative of the ability to integrate audiovisual speech stimuli. Audiovisual asynchrony was manipulated
RESEARCH Recorded Lectures as a Source of Cognitive Off-loading

Objective. To assess and elucidate the impact of student pharmacists’ knowledge of future access to recorded lectures on their ability to remember information presented during lecture. Methods. Pharmacy students viewed 50 minutes of videotaped lecture in a simulated class period. For the early lecture material, participants were instructed as to whether or not they would have future access to the recorded lectures for restudy prior to their test one week later. For the late lecture material, participants were instructed they would not have future access to lecture material. Participants were tested immediately following the lectures and again one week later. The primary outcome was the participants’ performance on the examination administered immediately following presentation of the late lecture material. If participants had preserved cognitive resources (eg, memory, attention) because of knowledge they would have future access to recorded lectures, performance was expected to be higher on the late lecture material. Results. Overall performance on the examinations did not differ between participants who knew they would have access to the lecture material for later restudy and those who did not. There was, however, loss of knowledge over time. Participants with knowledge of future access to recorded lectures wrote more notes, which correlated with better performance on the examination. Conclusion. These ﬁndings suggest knowledge of future access to recorded lectures did not enhance the ability of participants to remember other information and therefore, may not free-up cognitive resources that could be used for other tasks within the classroom.
The visibility of Helsinki’s branding attributes in the articles of international media representatives

May 2016 Author(s) Natalia Butina Degree programme Report/thesis title The visibility of Helsinki’s branding attributes in the articles of international media representatives Number of pages and appendix pages 63 + 1 Nowadays destination branding is one of the most powerful marketing tools in tourism industry. Strong brand gives a positive reputation that builds place competitiveness and longterm success. Helsinki as a tourist destination is becoming more recognizable and popular. The city is unique among Northern European cities. The lifestyle in the second-most northern capital city in the world is full of contrasts and activities in the form of hundreds of events and friendly people. Helsinki is still in the process of its brand creation. As a tourist destination, Helsinki needs own iconic image that would attract tourists and make the city more recognizable. The commissioner of the study Visit Helsinki is in charge of the operative city marketing operations. There are several main attributes that Visit Helsinki is bringing out in destination branding: urban nature, food, events, design. One part of Helsinki branding strategy is media visits, through which Visit Helsinki aims to develop Helsinki’s image. The theoretical part of the study introduces Helsinki as a tourist destination, describes Helsinki’s tourism strategy, and presents a concept of destination branding and the importance of public relations as brand communication. A case study approach was applied to explore how the branding attributes are represented in the articles of journalists who were visited to Helsinki. The researcher used a content analysis method to find out if there is any relationship between the richness of the organized program in Helsinki and the article’s attractiveness. The findings of the study indicate that branding attributes were presented very well in most of the analysed articles. Design is the most popular theme described in the analysed articles. There is no direct relationship between the richness of the organized program in Helsinki and the article’s attractiveness. However the analysis showed that such factors as a form of provided program: individually or in group, and the origin of potential tourist segment have to be taken into account in media visits planning.
FIXED POINT PROPERTIES OF PRECOMPLETELY AND POSITIVELY NUMBERED SETS

In this paper, we prove a joint generalization of Arslanov’s completeness criterion and Visser’s ADN theorem for precomplete numberings. Then we consider the properties of completeness and precompleteness of numberings in the context of the positivity property. We show that the completions of positive numberings are not their minimal covers and that the Turing completeness of any set A is equivalent to the existence of a positive precomplete A -computable numbering of any infinite family with positive A -computable numbering. In addition, we prove that each Σ 0 n -computable numbering ( n > 2 ) of a Σ 0 n -computable non-principal family has a Σ 0 n -computable minimal cover ν such that for every computable function f there exists an integer n with ν ( f ( n )) = ν ( n ) .
Outperforming the Stock Market Using Market Anomalies Outperforming the Stock Market Using Market Anomalies

The objective of this study is to explore the use of well-researched market anomalies to generate higher risk-adjusted returns than the overall stock market. Four specific market anomalies are examined: the small-firm effect; price reversals; the January effect; and the momentum effect. It focuses on historical evidence, anomaly characteristics, and potential risks. This study also explores the use of anomaly detection techniques, such as machine learning, in identifying market mispricings. It finds that a selective approach, combining market anomalies with traditional investment strategies, is crucial for effective implementation. This study provides insights for investors seeking to capitalize on market anomalies to achieve higher risk-adjusted returns.
Balanced Exploration and Exploitation Properties of Multi-Objective Sooty Tern Optimizer

—The Sooty Tern Optimization Algorithm (STOA) [1], a newly designed metaheuristic drawing inspiration from the migratory and predatory behaviors of the sea bird Sooty Tern, presents several notable advantages, including minimal parameterization. However, it is confined to addressing single-objective problems exclusively. In this work, we have enhanced the properties of exploration and exploitation to effectively penetrate the area of search. Subsequently, we extended the STOA to a multi-objective version called MOSTOA (Multi-Objective Sooty Tern Optimization Algorithm). This enhanced algorithm is designed to address multiple objectives in diverse problem domains. The MOSTOA utilizes an archive repository to store and retrieve the optimal solutions generated throughout the optimization cycle. From this population archive, leaders are chosen to guide the solutions of the main population towards promising search locations. Furthermore, the utilization of the grid mechanism and dynamic archiving approach serves the purpose of achieving a harmonious equilibrium between convergence and variety inside the final Pareto set. These strategies ensure that the obtained solutions exhibit both high quality and spread across the objective space. The proposed MOSTOA is validated on various well-known benchmarks functions. In addition, its performance is assessed in comparison to well-established cutting-edge algorithms. Our method produces very competitive results and, in most circumstances, exhibits improved convergence behavior with a good variety of solutions, as demonstrated by the experimental findings.
Pacific decadal oscillation and the decadal change in the intensity of the interannual variability of the South China Sea summer monsoon

Abstract The decadal variation of the intensity of the interannual variability (IIV) of the South China Sea summer monsoon (SCSSM) was partly modulated by the Pacific Decadal Oscillation (PDO) during the twentieth century. The SCSSM shows larger (smaller) IIV in the warm (cold) phase of the PDO. Results show that the IIV of the tropical Pacific SST and the ENSO–SCSSM relationship play key roles in the modulation of the PDO on the SCSSM IIV. In the warm phase of the PDO, the variability of the SST in the tropical Pacific tends to be larger than that in the cold phase, along with stronger ENSO events. Subsequently, the interaction between the tropical Pacific SST and the SCSSM becomes stronger via changing the strength and position of the Walker circulation and the anomalous western North Pacific anticyclone. Therefore, the large IIV of the tropical Pacific SST and the close ENSO–SCSSM relationship lead to the large IIV of the SCSSM in the warm phase of the PDO, and vice versa.
Augmented wound healing potential of photosensitive GelMA hydrogel incorporating antimicrobial peptides and MXene nanoparticles

Introduction: Wound healing is a delicate and complex process influenced by many factors. The treatment of skin wounds commonly involves the use of wound dressings, which remain a routine approach. An ideal dressing can provide protection and a suitable environment for wound surfaces by maintaining moisture and exhibiting good biocompatibility, mechanical strength, and antibacterial properties to promote healing and prevent infection. Methods: We encapsulated tick-derived antibacterial polypeptides (Os) as a model drug within a methylacrylyl gelatin (GelMA) hydrogel containing MXene nanoparticles. The prepared composite hydrogels were evaluated for their wound dressing potential by analyzing surface morphology, mechanical properties, swelling behavior, degradation properties, antibacterial activity, and cytocompatibility. Results: The results demonstrated excellent mechanical strength, swelling performance, degradation behavior, and antibacterial activity of the prepared composite hydrogels, effectively promoting cell growth, adhesion, and expression of antibacterial peptide activity. A full-thickness rat wound model then observed the wound healing process and surface interactions between the composite hydrogels and wounds. The composite hydrogel significantly accelerated wound closure, reduced inflammation, and sped epithelial formation and maturation. Discussion: Incorporating antibacterial peptides into GelMA provides a feasible strategy for developing excellent antibacterial wound dressings capable of tissue repair. In conclusion, this study presents a GelMA-based approach for designing antibacterial dressings with strong tissue regenerative ability.