Miracle-dz/UniFAR-FTUs huggingface dataset:
FGF‐2 stimulates migration of Kaposi's sarcoma‐like vascular cells by HGF‐dependent relocalization of the urokinase receptor

The spindle‐shaped cell line TTB was recently isolated from highly vascularized skin lesions of BKV/HIV‐1 tat transgenic mice and shown to possess an autocrine loop for hepatocyte growth factor (HGF). We show that fibroblast growth factor‐2 (FGF‐ 2) stimulates TTB cell migration and promotes polarization of uPAR at the leading edge of migrating cells. FGF‐stimulated TTB cells presented the typical migratory phenotype, with a triangular cell shape and concomitant breakdown of actin stress fibers and smooth muscle‐specific actin isoform. FGF‐2‐stimulated migration was blocked by antibodies against urokinase‐type plasminogen activator (uPA) or uPA receptor (uPAR) and by neutralizing anti‐HGF antibodies. The latter also inhibited uPAR relocalization at the cell surface of FGF‐2‐treated TTB cells. This points to a crosstalk between FGF‐2 and HGF that might mediate TTB cell migration by modulating the localization of cell surface uPAR. —Cavallaro, U. , Wu, Z. , Di Palo, A. , Montesano, R. , Pepper, M. S. , Maier, J. A. M. , Soria, M. R. FGF‐2 stimulates migration of Kaposi's sarcoma‐like vascular cells by HGF‐dependent relocalization of the urokinase receptor. FASEB J. 12, 1027–1034 (1998)
Asset Managers: Institutional Performance and Smart Betas

Using a dataset of $17 trillion of assets under management, we document that actively-managed institutional accounts outperformed strategy benchmarks by 86 (42) basis points gross (net) during 2000–2012. In return, asset managers collected $162 billion in fees per year for managing 29% of worldwide capital. Estimates from a Sharpe (1992) model imply that their outperformance comes from factor exposures ("smart beta"). If institutions had instead implemented mean-variance portfolios of institutional mutual funds, they would not have earned higher Sharpe ratios. Recent growth of the ETF market implies that asset managers are losing advantages held during our sample period.
DE- and EDPm- Compound Optimality for the Information and Probability-Based Criteria

Several optimality criteria have been considered in the literature as information-based criteria. The probability- based criteria have been recently proposed for maximizing the probability of a desired outcome. However, designs that are optimal for the information- based criteria may be inadequate for probability- based criteria. This paper introduces the DE- and EDP${}_{M}$ -- optimum designs for multi aims of optimality for Generalized Linear Models (GLMs). An equivalence theorem is proved for both compound criteria. Finally, two numerical examples are given to illustrate the potentiality of the proposed compound criteria.
An Empirical Study of the Dynamic Correlation of Brazilian Stock Returns

This article examines empirically the behavior of the correlation between the return of shares listed on the BMF& BOVESPA over the period from 2000 to 2015. To this end, we use multivariate GARCH models introduced by Bollerslev (1990) to remove the temporal series of arrays of conditional correlation of returns of stocks. With the temporal series of the largest eigenvalues of matrices of correlation estimated conditional, we apply statistical tests (unit root, structural breaks and trend) to verify the existence of stochastic trend or deterministic to the intensity of the correlation between the returns of the shares represented by eigenvalues. Our results confirm that both in times of crises at national and international turbulence, there is greater correlation between the actions. However, we did not find any long-term trend in time series of the largest eigenvalues of matrices of correlation conditional.
STRATEGI PEMBENTUKAN PORTOFOLIO SAHAM MENGGUNAKAN ANALISIS CLUSTER HIERARKI DAN PENILAIAN KINERJA OUT OF SAMPLE

Penelitian ini bertujuan untuk 1. ) menjelaskan pemilihan saham menggunakan analisis cluster hierarki, 2. ) menjelaskan pembentukan portofolio menggunakan metode MAD dengan empat strategi, 3. ) menjelaskan pemilihan portofolio efisien dengan efficient frontier , 4. ) menjelaskan pemilihan portofolio optimal dengan indeks Sharpe, 5. ) menjelaskan pemilihan portofolio optimal dengan indeks Sharpe . Data yang digunakan yaitu data saham yang termasuk di dalam saham LQ45 pada periode 31 Januari 2016 sampai 24 Juni 2018. Hasil penelitian menunjukkan bahwa pada penerapan metode hierarki yaitu average linkage dengan uji validasi banyaknya cluster menggunakan Davies Bouldin Index (DBI) menghasilkan banyaknya cluster yang optimal yaitu dua cluster dengan nilai DBI sebesar 0.6218. Sedangkan, perhitungan proporsi dana menggunakan metode Mean Absolute Deviation (MAD) dilakukan dengan empat strategi yang berbeda sehingga terbentuk empat portofolio. Pada tingkat risiko penurunan yang sama akan dipilih nilai penurunan return yang terkecil yaitu = 0.338054 sehingga portofolio efisien yang dipilih oleh investor adalah Portofolio 3. Adapun perhitungan indeks Sharpe dihasilkan nilai maksimal pada Portofolio 4 yaitu sebesar 0.277064739 sehingga Portofolio 4 merupakan portofolio optimal. Kemudian kinerja out of sample pada Portofolio 3 dan Portofolio 4 memberikan tingkat return tertinggi pada periode yang sama yaitu pada periode ke-15 dengan nilai return untuk Portofolio 3 yaitu sebesar dan nilai return untuk Portofolio 4 yaitu sebesar . Sehingga investor disarankan untuk menginvestasikan modal yang dimiliki pada masing-masing perusahaan sesuai proporsi dana sesuai Portofolio 4 dan dijual pada periode ke-15 karena pada periode selanjutnya nilai return akan mengalami penurunan. Keyword. Average Linkage , MAD, Efficient Frontier, Indeks Sharpe
Aquaculture Tries to Fill World’s Insatiable Appetite for Seafood

Total global fish production, including both wild capture fish and aquaculture, reached an all-time high of 154 million tons in 2011.1 (See Figure 1.) Wild capture was 90.4 million tons that year, up 2 percent from 2010.2 This followed a 1.6 percent decline from 2009 to 2010.3 The 2011 global capture figure matched the 2007 total of 90.3 million tons, which broke a four-year pattern of declining global wild capture.4 Since the late 1980s, however, wild capture production has essentially stagnated.5
Evaluation of WRF Model Hydrometeors Based on TMI Observations Using an Indirect Method

Abstract Using a microwave radiative transfer (MWRT) model with microwave brightness temperatures (TBs) observed from the Tropical Rainfall Measuring Mission (TRMM) Microwave Imager (TMI), an indirect approach evaluated hydrometeors generated from the Weather Research and Forecasting (WRF) model in the process of CHABA typhoon in August 2004. This study compares the simulated TBs generated from the microwave radioactive transfer model connected to the WRF model with the observed TBs derived from TMI and analyzes the differences between these TBs. The results indicate that the WRF model underestimates the amount and area of liquid and ice hydrometeors inside the typhoon center. The results also indicate relatively better agreement between the simulated and the observed TBs in the vertical polarization than in the horizontal polarization.
Valuing Information on GM Foods in the Presence of Country-of-Origin Labels

Information on production methods (genetic modification or organic production) and locations (country of origin) are commonly found on food package labels. Both pieces of information may be used as a proxy for food safety and quality by consumers. Our study investigates the interactive effects between information on production method and COOL by conducting choice experiments in the European Union, United States and Japan. This study also investigates the effect of information about potential benefits of biotechnology on consumer acceptance of GM foods. Results indicate that consumers preferred GM foods produced domestically to GM foods imported from foreign countries, and individuals with information on consumer benefits, producer benefits, and environmental benefits were willing to pay more than individuals without information in some cases, but the effect of information varied by type of information, location, and the country of origin of the products.
Vertical Specialization and Nonstationarities in International Trade Series

In this paper, we analyze the statistical properties of a large sample of trade openness series in the Second Era of Globalization (from 1948 to the recent crisis) and find a clear stationary pattern for developing countries versus a unit root pattern for developed countries. Most interestingly, we show how the progress of vertical specialization can rationalize this presence of unit roots in the ratio of export to GDP. We use scattered data of vertical specialization (defined as the imported input content of exports) for ten OECD countries to construct yearly export series free from the upwards bias introduced by vertically specialised trade in the official values. We find that when the statistical analysis is applied to the unbiased series of openness, they become trend stationary for nearly all the countries, corroborating the responsibility of vertical specialization in the presence of unit roots.
The French Digital Kitchen: Implementing Task-Based Language Teaching Beyond the Classroom

This paper reports on the French Digital Kitchen, a design-based project which drew on digital sensor technology to take the principles of Task-Based Language Teaching (TBLT) out of the classroom and into the real-world environment of a kitchen. The project aimed to produce a situated language learning environment where learners could learn aspects of French language and cuisine whilst performing a real-world task. The article describes the blend of TBLT, human-computer interaction (HCI) and user-centred design (UCD) principles the authors adopted in constructing and trialling the kitchen, using multiple data sources. An example of a task cycle is then presented to illustrate (by using CA analysis of transcripts) how learners have used the resources of the kitchen to accomplish the task. The authors’ findings show how the integration of the pedagogical and technological design enabled learners to notice and manipulate new vocabulary items.
Ecology, silviculture, and management of Black Hills ponderosa pine

This paper presents a broad-based synthesis of the general ecology of the ponderosa pine ecosystem in the Black Hills. This synthesis contains information and results of research on ponderosa pine from numerous sources within the Black Hills ecosystem. We discuss the silvical characteristics of ponderosa pine, natural disturbances that govern ecosystem processes, wildlife habitat and management, various silvicultural methods to manage ponderosa pine forests, and watershed management of the Black Hills.
Resilience to a changing climate: carbon stocks in two organic farming systems in Africa

Our changing climate poses challenges to sustainable agriculture. Here we present two case studies on climate change mitigation of agricultural systems. In Egypt, desert soils were reclaimed for arable land through a combined approach of irrigation and compost application. The use of organic fertilizers is inherent to organic agriculture and builds upon soil quality with high water-holding capacity. In Congo, cocoa farmers adopted agro forestry practices promoted by organic premiums, which included shade management. Shade management is a tool for biodiversity conservation and contributes to higher resilience through less soil erosion and better soil fertility. In Egypt, the use of compost lead to a total carbon sequestration of almost 30 t C/ha in the course of 30 years of land use. In Congo, shade management increased the amount of stored carbon from 17 t C/ha in poorly shaded plantations to over 60 t C/ha in more densely shaded plantations. These studies illustrate the multifunctionality of sustainable agricultural practices and underline the benefits of organic principles, in particular for regions that are vulnerable to the adverse effects of climate change.
Phases, Modalities, Spatial and Temporal Locality: Domain Specific ML Prefetcher for Accelerating Graph Analytics

Memory performance is a key bottleneck in accelerating graph analytics. Existing Machine Learning (ML) prefetchers encounter challenges with phase transitions and irregular memory accesses in graph processing. We propose MPGraph, an ML-based Prefetcher for Graph analytics using domain specific models. MPGraph introduces three novel optimizations: soft detection of phase transitions, phase-specific multi-modality models for access delta and page predictions, and chain spatio-temporal prefetching (CSTP) for prefetch control. Our transition detector achieves 34.17--82.15% higher precision compared with Kolmogorov-Smirnov Windowing and decision tree. Our predictors achieve 6.80--16.02% higher F1-score for delta and 11.68--15.41% higher accuracy-at-10 for page prediction compared with LSTM and vanilla attention models. Using CSTP, MP-Graph achieves 12.52--21.23% IPC improvement, outperforming state-of-the-art non-ML prefetcher BO by 7.58--12.03% and ML-based prefetchers Voyager and TransFetch by 3.27--4.58%. For practical implementation, we compress the prediction models to reduce the storage and latency overhead. MPGraph with the compressed models still shows significantly superior accuracy and coverage compared to BO, with 3.58% IPC improvement.
On the importance of Sumatra’s East Coast for waterbirds, with notes on the Asian Dowitcher Limnodromus semipa1matus

Since 1984, three surveys were conducted along the east coast of Sumatra. Several coastal wetlands appeared to be of international importance for waterbirds (according to the criteria of the Ramsar Convention). More than 10,000 large waterbirds were identified, including large numbers of Milky Storks Mycteria cinerea and Lesser Adjutants Leptoptilos javanicus,, and over 100,000 migratory waders (28 species) were counted. The observation of a minimum total of 3,800 Asian Dowitchers Limnodromus semipalmatus indicates that the east coast of Sumatra is the main wintering area of the species. In areas of high conservation importance, data were collected on habitat and threats. Several of these areas face heavy reclamation pressure, which necessitates urgent conservation action.
ACTA SCIENTIARUM POLONORUM

The investigation covered two kinds of the raw material (the leafy part and whole plants of dill 20 cm in height), varied processing before freezing (blanching of the raw material or without blanching), and two different storage temperatures (–20°C and –30°C) during 12-month storage, analyses of frozen products being conducted every 3 months. In comparison with whole dill plants the content of dry matter in leaves was higher by 36%, of total sugars by 45%, starch by 6%, dietary fibre by 35%, polyphenols by 58%, volatile oils by 32%, and total acids by 36%. The activity of peroxidase and catalase in leaves was higher by 59% and 71% respectively. In both usable parts of dill blanching caused significant changes in the level of all chemical components except for dietary fibre. Irrespective of the usable part, preliminary processing and storage temperatures, refrigerated storage caused slight changes in the level of dry matter, total sugars, starch, dietary fibre and total acids. Blanching before freezing and a lower temperature of refrigerated storage resulted in better retention of polyphenols and volatile oils in the two usable parts. At each stage of the investigation frozen leaves were characterized by higher sensory quality. Maintaining high sensory quality of frozen dill for three months did not require blanching and a storage temperature of –20°C was adequate. Storage at –30°C or at –20°C but with blanching before freezing was indispensable for maintaining very good quality for six months. Frozen dill stored for more than six months maintained good quality only when blanched raw material had been used; in addition to this, a lower storage temperature had a favourable effect on maintaining sensory quality, particularly in the case of 12-month storage.
Thermal Stability of Volatiles in the North Polar Region of Mercury

Wet Mercury Radar observations of Mercury's poles in the 1990s revealed regions of high backscatter that were interpreted as indicative of thick deposits of water ice; however, other explanations have also been proposed (see the Perspective by Lucey). MESSENGER neutron data reported by Lawrence et al. (p. 292, published online 29 November) in conjunction with thermal modeling by Paige et al. (p. 300, published online 29 November) now confirm that the primary component of radar-reflective material at Mercury's north pole is water ice. Neumann et al. (p. 296, published online 29 November) analyzed surface reflectance measurements from the Mercury Laser Altimeter onboard MESSENGER and found that while some areas of high radar backscatter coincide with optically bright regions, consistent with water ice exposed at the surface, some radar-reflective areas correlate with optically dark regions, indicative of organic sublimation lag deposits overlying the ice. Dark areas that fall outside regions of high radio backscatter suggest that water ice was once more widespread. Spacecraft data and a thermal model show that water ice and organic volatiles are present at Mercury’s north pole. [Also see Perspective by Lucey] Thermal models for the north polar region of Mercury, calculated from topographic measurements made by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft, show that the spatial distribution of regions of high radar backscatter is well matched by the predicted distribution of thermally stable water ice. MESSENGER measurements of near-infrared surface reflectance indicate bright surfaces in the coldest areas where water ice is predicted to be stable at the surface, and dark surfaces within and surrounding warmer areas where water ice is predicted to be stable only in the near subsurface. We propose that the dark surface layer is a sublimation lag deposit that may be rich in impact-derived organic material.
FUTURE VISION OF TRANSMISSION AND DISTRIBUTION 2030

This paper describes the work of the IEC ACTAD TF of future vision of T&D 2030. Penetration of renewable energy (Photovoltaic generation and Wind power) continues to increase rapidly. Accordingly, T&D systems have to expand and develop, including the adoption of countermeasures to stabilize the fluctuation of frequency and voltage of the power system. Voltage control of distribution systems and management of reverse current flow have already been implemented and large scale electric batteries are now being verified for application in transmission substations. HVDC and UHV transmission will also continue to be important technologies and are described in this paper.
Initial growth of Tabebuia aurea in salinized soil corrected with elemental sulfur.

Os solos degradados por sais ocorrem em todo o mundo, particularmente em regiões áridas e semiáridas da terra, onde a precipitação pluviométrica é limitada e, ou mal distribuída ou as duas situações simultaneamente. Objetivou-se avaliar o efeito de doses de enxofre elementar sobre na correção de um solo comprometido por excesso de sais e de sódio e no crescimento inicial de craibeira (Tabebuia aurea). O experimento foi conduzido em casa de vegetação utilizando-se amostras de um solo salino-sódico de textura franco arenosa. Empregou-se o delineamento inteiramente casualizado, com cinco tratamentos referentes às doses de enxofre elementar (0, 50, 100, 150 e 200% da dose correspondente a necessidade de gesso) em quatro repetições. O solo foi acondicionado em vasos de 6 dm 3 e incubado com o corretivo por 20 dias, quando foi analisado quanto à salinidade e sodicidade. Este procedimento foi repetido após a aplicação de duas lâminas de lixiviação dos sais em intervalo de 20 dias. As doses enxofre elementar proporcionaram diminuição dos valores de pH, PST, RAS e dos teores solúveis de sódio. Por outro lado, houve aumento dos teores de cálcio e magnésio do extrato de saturação. Pelos resultados, o enxofre diminui a alcalinidade e a sodicidade do solo e eleva os teores de cálcio e magnésio, sendo que a dose de S que corrigiu o solo pela redução de sua PST para 15% foi de 45,5% da necessidade de enxofre. Os valores máximos de crescimento em altura e produção de matéria seca da parte aérea e de raízes foram obtidos nas doses de S correspondentes a 48, 45 e 40% da necessidade de gesso, respectivamente.
EU ETS Phase 3 Benchmarks - Implications and Potential Flaws

In its third Phase (2013-20), the European Union Emissions Trading Scheme allocation methodology is shifting from grandfathering to a combination of auctioning and benchmarking. Free allocation is now be devoted to non-electricity generators only (save exemption), and is linearly decreasing throughout the Phase with a view of no free allocation in 2027. Benchmark-based free allocation is meant to reward lowest CO2-intensive installations as opposed to grandfathering, which allocated allowances based on historical emissions levels. This policy note describes the concrete implications involved by this shift in allocation methodology, and addresses the potential flaws of benchmarking-based allocation, using data from French nstallations Phase 3 provisional free allocation.
A review of soil-steel interface testing with the ring shear apparatus

The local shaft capacity of displacement piles is governed by effective stress friction laws. Laboratory tests carried out on clay soils in the ring-shear apparatus described by Bishop et al. (1971) predict reasonably accurately the soil-steel interface friction angles (δ) measured directly in the field with specially instrumented piles. The laboratory test values of δ depend on: the soil grading and mineral composition; interface material and roughness; and in some cases previous shearing history. Recognising these factors, Jardine and Chow (1996) recommended in their pile design procedure that in clay soils site-specific soil-steel interface shear tests should be performed that model the above factors. This paper explores (i) the possible sensitivity of δ to apparatus type and test procedure, and (ii) differences that can arise between test data and the "default" guidance curves given by Jardine and Chow. Results are presented of a series of comparative soil-steel interface ring shear tests, involving the relatively simple "Bromhead" equipment and the more complicated "Bishop" apparatus, where clay soils of varying plasticity were sheared against a standard steel pile interface with the roughness of a typical pile. It is shown that δ is not unduly sensitive to the choice of apparatus. Recommendations are made on how the commercially available "Bromhead" apparatus should be used to aid pile design in clays. In addition, a summary of recently performed interface ring-shear test results is used to comment on the "default curves" offered by Jardine and Chow for clays. Site-specific tests are strongly recommended for all new site investigations; they are simple and inexpensive to perform, and provide the most secure means of ensuring a reliable balance between safety and economy in pile design.
Tourism in China: Policy and Development Since 1949

Part 1: Theoretical and Contextural Background 1. Introduction 2. Context, History and Overview 3. The Conceptual Framework Part 2: Tourism Development and Policy Making in China from 1949 4. Changing National Models of China From 1949 5. Tourism Politics in Mao Zedong's Era 6. The National Policy-Makers 7. Deng Xiaoping's Era: A Period of Change 8. The Collective Leadership Era Part 3: Four Particular Regions of China 9. Tourism Policy Issues in Four Particular Regions Part 4: Theoretical and Practical Implications 10. Theoretical Implications 11. Experiences and Lessons