Miracle-dz/UniFAR-FTUs huggingface dataset:
Presumed uremic optic neuropathy in a patient with Senior–Loken syndrome

A patient who had been diagnosed with infantile retinal dystrophy developed renal failure in his twenties, at which time the diagnosis was revised to Senior–Loken syndrome. He was poorly compliant. At 36 years old, he experienced a sudden drop in visual acuity in the setting of cramping and fatigue and was found to be in uremic crisis. Six months after the event and its treatment, his vision failed to improved. Optic nerve pallor was out of proportion to the retinal dystrophy, and the presumed reason for his new visual loss was uremic optic neuropathy. The patient's younger sister also had been diagnosed with infantile retinal dystrophy, and metabolic screening confirmed subclinical renal dysfunction that was to be carefully followed going forward. Infantile retinal dystrophy can be associated with later systemic disease. Early detection of such disease can potentially decrease morbidity. Patients with retinal dystrophy can develop new visual loss from causes other than the retinopathy itself.
Uplift, exhumation, and deformation in the Chinese Tian Shan

The terranes composing the basement of the Tian Shan were originally sutured together during two collisions in Late Devonian–Early Carboniferous and Late Carboniferous–Early Permian time. Since then, the range has repeatedly been uplifted and structurally reactivated, apparently as a result of the collision of island arcs and continental blocks with the southern margin of Asia far to the south of the range. Evidence for these deformational episodes is recorded in the sedimentary histories of the Junggar and Tarim foreland basins to the north and south of the range and by the cooling and exhumation histories of rocks in the interior of the range. Reconnaissance apatite fission-track cooling ages from the Chinese part of the range cluster in three general time periods, latest Paleozoic, late Mesozoic, and late Cenozoic. Latest Paleozoic cooling is recorded at Aksu (east of Kalpin) on the southern flank of the range, at two areas in the central Tian Shan block along the Dushanzi-Kuqa Highway, and by detrital apatites at Kuqa that retain fission-track ages of their sediment source areas. Available Ar/Ar cooling ages from the range also cluster within this time interval, with very few younger ages. These cooling ages may record exhumation and deformation caused by the second basement suturing collision between the Tarim–central Tian Shan composite block and the north Tian Shan. Apatite data from three areas record late Mesozoic cooling, at Kuqa on the southern flank of the range and at two areas in the central Tian Shan block. Sedimentary sections in the Junggar and Tarim foreland basins contain major unconformities, thick intervals of alluvial conglomerate, and increased subsidence rates between about 140 and 100 Ma. These data may reflect deformation and uplift induced by collision of the Lhasa block with the southern margin of Asia in latest Jurassic–Early Cretaceous time. Large Jurassic intermontane basins are preserved within the interior of the Tian Shan and in conjunction with the fission-track data suggest that the late Mesozoic Tian Shan was subdivided into a complex of generally east-west–trending, structurally controlled subranges and basins. Apatite data from five areas record major late Cenozoic cooling, at sites in the basin-vergent thrust belts on the northern and southern margins of the range, and along the north Tian Shan fault system in the interior of the range. The thrust belts *Now at ExxonMobile Exploration Company, P.O. Box 4778, Houston, Texas 77060, USA Dumitru, T.A. , et al., 2001, Uplift, exhumation, and deformation in the Chinese Tian Shan, in Hendrix, M.S., and Davis, G.A. , eds., Paleozoic and Mesozoic tectonic evolution of central Asia: From continental assembly to intracontinental deformation: Boulder, Colorado, Geological Society of America Memoir 194, p. 71–99. on May 22, 2015 memoirs.gsapubs. org Downloaded from
The two-dimensional resonance of sediment-filled valleys

Abstract This paper presents a numerical study of the response of relatively embanked sediment-filled valleys to incident plane SH , SV , and P waves, in the two-dimensional case. The Aki-Larner technique used here is shown to be reliable even for steep interface slopes. Numerical results show the existence and the importance in such valleys of specific two-dimensional resonance patterns, which may be classified in three categories: the antiplane shear modes, corresponding to SH motion; the in-plane shear modes ( SV ); and the in-plane bulk modes ( P ). Each of them is characterized by the consistency of the peak frequencies, and the in-phase motion (modulo 180°) across the whole valley. They induce a very large amplification, even in the case of significant damping (up to 4 times the corresponding one-dimensional prediction), a very long duration of motion, and large differential motion. The characteristics of the fundamental modes are in good qualitative agreement with the relevant experimental observations. The existence of this two-dimensional resonance is controlled by the shape ratio (thickness to half-width ratio) and the velocity contrast: a quantitative relationship is proposed in the SH case. The frequency of these resonance modes, for each pattern, is shown to depend only on two parameters: the one-dimensional resonance frequency at the valley center and the shape ratio. A simple model of a soft rectangular inclusion is shown to provide satisfactory quantitative formulas to estimate the fundamental resonance frequencies of any valley. As to the amplitude of this two-dimensional resonance, the general trends of its dependence on the different valley parameters (shape ratio, velocity contrast, Poisson ratio, damping) and on the incident wave field characteristics (wave type, incidence angle) are indicated. An important result, however, for earthquake engineering purposes is that both the two-dimensional resonant frequencies and amplification values differ a lot from their “classical” one-dimensional estimates.
Mesenchymal Stem Cells for Prophylaxis of Chronic Graft-vs-Host Disease After Haploidentical Hematopoietic Stem Cell Transplant

Importance Chronic graft-vs-host disease (GVHD) limits the long-term benefit of haploidentical hematopoietic stem cell transplant (HSCT). This clinical trial evaluated repeated infusions of umbilical cord mesenchymal stem cells (MSCs) during the early stage (45 days and 100 days) after haplo-HSCT to prevent chronic GVHD. Objective To determine whether repeated infusions of MSCs during the early stage after haplo-HSCT decreases the incidence of severe chronic GVHD. Design, Setting, and Participants This open-label, multicenter, parallel randomized clinical trial was conducted from April 2016 to January 2022. Eligibility criteria included a diagnosis of acute leukemia and having a haploidentical, suitable related donor for HSCT. The median (range) follow-up time was 39.0 (1.5-67.0) months. Interventions The enrolled patients with a haploidentical relative for HSCT received the modified busulfan/cyclophosphamide + antithymocyte globulin modified regimen and standard GVHD prophylaxis. Patients were randomly chosen to receive MSCs (the MSC group) (1 × 106 cells/kg, every 2 weeks, starting from 45 days after transplant, 4 times total) or regular prophylaxis (control group). Main Outcome and Measure The cumulative incidence of severe chronic GVHD. Results Of 158 patients, 58 (36.7%) were female individuals; the median (range) age for the MSC and control groups was 28 (18-60) years and 28 (18-56) years, respectively. A total of 158 patients were screened, and 148 patients were randomly assigned to the MSC group (n = 74) or control group (n = 74) 1 day before MSCs infusion. The estimated 2-year cumulative incidence of severe chronic GVHD was 5.4% (95% CI, 1.8%-14.0%) in the MSC group and 17.4% (95% CI, 10.1%-28.5%) in the control group (hazard ratio [HR], 0.29; 95% CI, 0.10-0.88; P = .03). There was no difference between the MSC and control groups in the cumulative incidence of leukemia relapse (HR, 1.17; 95% CI, 0.55-2.47; P = .68). The cumulative incidence of stage II to IV acute GVHD in the MSC group was significantly lower than that in the control group (HR, 0.25; 95% CI, 0.09-0.67; P = .01). The MSC group had better GVHD-free and relapse-free survival rates than the control group (HR, 0.62; 95% CI, 0.39-0.98; P = .04). Conclusions and Relevance The results of this randomized clinical trial show that early repeated infusions of MSCs decreased the incidence and severity of chronic GVHD, and the incidence and severity of acute GVHD manifested as a better GVHD-free and relapse-free survival rate for patients after haplo-HSCT. Trial Registration Chinese Clinical Trial Registry: ChiCTR-IIR-16007806
Personal Misconduct Elicits Harsher Professional Consequences for Artists (vs. Scientists): A Moral-Decoupling Process.

Recent years have brought increased accountability for personal misconduct, yet often, unequal consequences have resulted from similar offenses. Findings from a unique archival data set (N = 619; all university faculty) and three preregistered experiments (N = 2,594) show that the perceived artistic-versus-scientific nature of the offender's professional contributions influences the professional punishment received. In Study 1, analysis of four decades of university sexual-misconduct cases reveals that faculty in artistic (vs. scientific) fields have on average received more severe professional consequences. Study 2 demonstrates this experimentally, offering mediational evidence that greater difficulty morally decoupling art (vs. science) contributes to the phenomenon. Study 3 provides further evidence for this mechanism through experimental moderation. Finally, Study 4 shows that merely framing an individual's work as artistic versus scientific results in replication of these effects. Several potential alternative mechanisms to moral decoupling are tested but not supported. Practical and theoretical implications are discussed.
Identifying ecological corridors using shortest path algorithm based on raster data

Ecological corridor,which plays an important role in biodiversity protection,is defined as a stretch of nature mosaic that facilitates the migration of animals.Many GIS software packages use raster cost surface to identify the path of least resistance between source and destination.Limitation of these methods is that only a single path can be identified.However,ecological corridors should be more complicated and more redundant.Many alternative paths with less cost might exist in fact for animals may not choose the optimum path when moving between different habitats.In this paper,a new approach based on Spatial Analyst Tools of ArcGIS using raster data is proposed to identify the redundant routes.Firstly,the resistance cost surface moving from source to adjacent raster was defined.Secondly,the accumulated least-cost raster from both source and destination habitat to any other raster on the cost surface was evaluated.Two accumulated least-cost raster were added by raster calculation module.The value of the added raster is the accumulated least-cost which passed the current raster.Thirdly,the corridor was obtained by extracting the added raster with a certain value.Corridors of six simulated landscape patterns with different spatial autocorrelations were used to assess this procedure.The results showed that the corridors obtained by the procedure include not only the optimum path,but also some sub-optimum paths.The corridor is redundant and fit for describing the migration behavior of animals.Lastly,the identification of the ecological corridors in West Bank Pilot Planning Area of Changsha was taken as an example.The results showed that eleven key habitats existed in the study area.Corridors of twenty adjacent habitat pairs were analyzed.The results showed that all the corridors were of certain width and some of the corridors had furcation or even bypath.However,there are some bottlenecks in some corridors,which become the key zone for the ecological restoration.
Associations Between Autoimmune Disease and the Development of Age-Related Macular Degeneration

Purpose The pathogenesis of age-related macular degeneration (AMD) likely implicates the dysregulation of immune response pathways. Several studies demonstrate that the pathogenic elements of AMD resemble those of autoimmune diseases, yet the association between AMD development and most autoimmune diseases remain unexplored. Methods We conducted a case-control analysis of patients ages 55 and older with new-onset International Classification of Diseases (ICD) coding of dry, wet, or unspecified AMD between 2005 and 2019 in the Merative MarketScan Commercial and Medicare Databases. The diagnosis of an autoimmune disease was defined by an outpatient or inpatient claim with a relevant ICD code in the 12 months before the index visit. Conditional multivariable logistic regression, adjusted for AMD risk factors, was used to calculate odd ratios and 95% confidence intervals. Results We identified 415,027 cases with new-onset ICD coding for AMD matched with propensity scores to 414,853 controls. In total, 16.1% of cases and 15.9% of controls were diagnosed with any autoimmune disease. The diagnosis of any autoimmune disease did not affect the odds of new-onset ICD coding for AMD in multivariable regression (OR = 1.01; 95% CI, 0.999–1.02). Discoid lupus erythematosus (OR = 1.29; 95% CI, 1.12–1.48), systemic lupus erythematosus (SLE) (OR = 1.21; 95% CI, 1.15–1.27), giant cell arteritis (OR = 1.19; 95% CI, 1.09–1.30), Sjogren's syndrome (OR = 1.17; 95% CI, 1.09–1.26), and Crohn's disease (OR = 1.13; 95% CI, 1.06–1.22) increased the odds of a new-onset ICD coding for AMD. Conclusions Most autoimmune diseases do not affect the odds of developing AMD but several common autoimmune disorders such as SLE and Crohn's disease were associated with modestly increased odds of AMD. Further studies are needed to validate and investigate the underlying mechanisms of these associations.
Mars Exploration Rover mission : Mars exploration rover mission and landing sites

In January 2004 the Mars Exploration Rover mission will land two rovers at two different landing sites that show possible evidence for past liquid-water activity. The spacecraft design is based on the Mars Pathfinder configuration for cruise and entry, descent, and landing. Each of the identical rovers is equipped with a science payload of two remote-sensing instruments that will view the surrounding terrain from the top of a mast, a robotic arm that can place three instruments and a rock abrasion tool on selected rock and soil samples, and several onboard magnets and calibration targets. Engineering sensors and components useful for science investigations include stereo navigation cameras, stereo hazard cameras in front and rear, wheel motors, wheel motor current and voltage, the wheels themselves for digging, gyros, accelerometers, and reference solar cell readings. Mission operations will allow commanding of the rover each Martian day, or sol, on the basis of the previous sol's data. Over a 90-sol mission lifetime, the rovers are expected to drive hundreds of meters while carrying out field geology investigations, exploration, and atmospheric characterization. The data products will be delivered to the Planetary Data System as integrated batch archives.
A rare disease in adult women: Gaucher disease

Gaucher disease is a rare, autosomal recessive disorder caused by inborn errors of metabolism. Globally, more than 27 million people are born each year, and approximately 19,000 neonates are born with lysosomal storage disease. We report a rare case of Gaucher disease in an adult female patient of non-consanguineous parents in a subtropical area of Jiangxi Province, China. This area has a high prevalence of schistosomiasis. The diagnosis of this case posed a great challenge because of the possible differential diagnoses of pancytopenia with hepatomegaly and giant splenomegaly. The key component of the patient’s diagnosis was her medical history in which it was documented that her brother had died of hepatocellular carcinoma of unknown origin. We diagnosed the patient through a combination of a pathological biopsy and imaging plus the patient’s medical history.
Redundant microtubule crosslinkers prevent meiotic spindle bending to ensure diploid offspring in C. elegans

Oocyte meiotic spindles mediate the expulsion of ¾ of the genome into polar bodies to generate diploid zygotes in nearly all animal species. Failures in this process result in aneuploid or polyploid offspring that are typically inviable. Accurate meiotic chromosome segregation and polar body extrusion require the spindle to elongate while maintaining its structural integrity. Previous studies have implicated three hypothetical activities during this process, including microtubule crosslinking, microtubule sliding and microtubule polymerization. However, how these activities regulate spindle rigidity and elongation as well as the exact proteins involved in the activities remain unclear. We discovered that C. elegans meiotic anaphase spindle integrity is maintained through redundant microtubule crosslinking activities of the Kinesin-5 family motor BMK-1, the microtubule bundling protein SPD-1/PRC1, and the Kinesin-4 family motor, KLP-19. Using time-lapse imaging, we found that single depletion of KLP-19KIF4A, SPD-1PRC1 or BMK-1Eg5 had minimal effects on anaphase B spindle elongation velocity. In contrast, double depletion of SPD-1PRC1 and BMK-1Eg5 or double depletion of KLP-19KIF4A and BMK-1Eg5 resulted in spindles that elongated faster, bent in a myosin-dependent manner, and had a high rate of polar body extrusion errors. Bending spindles frequently extruded both sets of segregating chromosomes into two separate polar bodies. Normal anaphase B velocity was observed after double depletion of KLP-19KIF4A and SPD-1PRC1. These results suggest that KLP-19KIF4A and SPD-1PRC1 act in different pathways, each redundant with a separate BMK-1Eg5 pathway in regulating meiotic spindle elongation. Depletion of ZYG-8, a doublecortin-related microtubule binding protein, led to slower anaphase B spindle elongation. We found that ZYG-8DCLK1 acts by excluding SPD-1PRC1 from the spindle. Thus, three mechanistically distinct microtubule regulation modules, two based on crosslinking, and one based on exclusion of crosslinkers, power the mechanism that drives spindle elongation and structural integrity during anaphase B of C.elegans female meiosis.
Surface water quality monitoring of an agricultural watershed for nonpoint source pollution control

Water pollution is a major environmental problem in the United States. To improve the surface water quality of the 2,493 ha (6,160 ac) Coulee Baton watershed in Louisiana, a collaborative nonpoint source pollution control study was initiated in 2004. Conservation measures and best management practices (BMPs) including cross-fencing of pasturelands (726.9 m [2,385 ft]), irrigation land leveling (12.9 ha [32 ac]), grade stabilization structures (two), irrigation water pipeline (975.4 m [3,200 ft]), and a livestock well covering a total of 92.7 ha (229 ac) of agricultural land, and repair or replacement of 80 septic systems in the watershed were voluntarily implemented by landowners and homeowners. Water samples were collected from seven monitoring sites for 66 rain events from September 24, 2009, to August 9, 2011. Laboratory determinations of water samples included total suspended solids (TSS), total dissolved solids (TDS), total solids (TS), five-day biological oxygen demand (BOD5), nitrate/nitrite-nitrogen (NO3/NO2-N), soluble reactive phosphate (SRP), total phosphorus (TP), total Kjeldahl N (TKN), chloride (Cl), fluoride (Fl), sulfate (SO4), and fecal coliform counts. Surface water temperature, dissolved oxygen (DO), turbidity, conductivity, and pH were determined in the field using YSI Sonde (YSI Incorporated, Yellow Springs, Ohio). For the watershed, DO, BOD5, and TS concentrations and fecal coliform count ranged, respectively, between 1.2 and 14.1 mg L−1 (ppm), 2 and 40.1 mg L−1, 35 and 5,719 mg L−1, and 400 × 106 and 17 × 106 most probable number (MPN) per 100 mL. The months of March, April, June, and September showed, on average, higher concentrations of TS and TDS, fecal coliform count, NO3/NO2-N, and SRP and TP, respectively. As compared to the ongoing BMPs, the post-BMPs, TSS, NO3/NO2-N, SRP, and BOD5 concentrations, on average, were lower by 56.2%, 23.1%, 82.5%, and 27.4%, respectively. Developed land use types and the failed septic systems were identified as major sources of fecal coliform pollution. These results suggest comprehensive strategies are necessary for effective nonpoint source pollution control in agricultural watersheds.
Ecological Study of Violence against Children in Provinces of Iran: A Cluster Analysis

Background and purpose: Petroleum hydrocarbons are one of the most common persistent organic pollutants in the environment. Phytoremediation is a new technology in which the resistant plants are used to remove or reduce organic and mineral contamination and hazardous environmental substances. The purpose of this study was to evaluate the effect of Vetiveria Zizanioides plants on total petroleum hydrocarbons (TPH) removal in soil contaminated by oil in different concentrations of oil pollution in Khuzestan industrial area. Materials and methods: The soil samples were collected from the areas around Ahvaz oil field and were contaminated by oil in different concentrations (5%, 7%, and 10 % w/w). TPH measurement was done (and repeated twice) during four months in five retention time. Determination of TPH concentration in GC was performed using FID detector. Results: According to the results, the best efficiency of Vetiveria Zizanioides in removal of TPH was found in treatment with 5% oil pollution (91%) during 120 days. Most changes in microbial population occurred in 7% oil pollution (106 × 9.78 CFU/g) in 120 days. Conclusion: Vetiveria Zizanioides showed to be highly capable of removing TPH from contaminated soil.
Simulation of an EV-HEV Charging Station for Multichemistry Batteries Using Energetic Macroscopic Representation (REM)

Massification of electric vehicles (EV) and hybrid electric vehicles (HEV) requires the implementation and optimization of battery charging stations adapted to charge multi-chemistry batteries. Charging algorithms must identify the battery technology (Li-Ion and NiMH) and perform a charge which minimize the charging time while maximize the batteries lifetime. In this paper, Energetic Macroscopic Representation formalism is used to model a charging station with integration of photovoltaic generators. Simulation results illustrate the recharge of a Nissan Leaf and a Renault Twizy Li-Ion - EV and a Toyota Prius NiMH HEV charging.