Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Sidedness on the Efficacy of Anti-EGFR-Based First-Line Chemotherapy in Advanced Colorectal Cancer Patients in Real-Life Setting—A Nation-Wide Retrospective Analysis (RACER)

Simple Summary Controlled clinical trials are one of the most important sources of medical knowledge, but their results are not always identical to those observed later in normal day-to-day practice. Therefore, real-world studies are needed to investigate those differences. The targeted agents cetuximab and panitumumab, combined with chemotherapy, are an effective treatment for metastatic colon cancer, provided that certain mutations have not occurred in cancer cells (namely activating mutations in KRAS, NRAS or BRAF genes). Recently, it was found that the outcomes of the aforementioned therapy differ depending on which part of the colon the tumour originates from. We conducted a real-world study on 842 patients treated at 16 cancer centres. The study confirmed that metastatic cancer that originated in the right part of the colon has a lower response to cetuximab or panitumumab-based treatment. Abstract Anti-EGFR antibodies combined with chemotherapy doublets are a cornerstone of the upfront treatment of colorectal cancer. RAS and BRAF mutations are established negative predictive factors for such therapy. The primary tumour located in the proximal colon has recently emerged as another negative predictive factor. We have conducted a retrospective multicentre study to collect data on real-world population characteristics, practice patterns, and outcomes in patients with metastatic colorectal cancer treated in a first-line setting with either cetuximab or panitumumab in combination with either FOLFOX or FOLFIRI chemotherapy. The presented analysis focuses on the impact of the primary tumour location. 126 of 842 patients analysed (15.0%) had proximal primary. It was associated with a lower BMI at diagnosis, mucinous histology, and peritoneal metastases. It was also associated with inferior treatment outcomes in terms of response ratio: 59.4% vs. 74.22% (odds ratio [OR] 0.51, 95% CI 0.33–0.78, p = 0.010), and median depth of response: −36.7% vs. −50.0% (p = 0.038). There was only a borderline non-significant trend for inferior PFS in patients with proximal tumours. OS data was incomplete. The presented analysis confirms the negative impact of tumour sidedness on the efficacy of an upfront anti-EGFR-chemotherapy combination and provides valuable data on real-world population characteristics.
Service innovation capability: a systematic literature review and research agenda

ABSTRACT Though singular or discrete service innovations are accepted as essential to the performance and survival of organizations, practitioners and researchers are increasingly directing their attention towards the firm-level capability that underlies their repeated and continuous introduction, commonly referred to as service innovation capability (SIC). However, compared to the rich body of literature on the innovation capability of manufacturers and industrial organizations, SIC is poorly understood by managers and service researchers and there is no consensus on its definition, antecedents, outcomes, or dimensions. This study remedies this protracted gap through a comprehensive review of 45 academic journals reporting on firm-level studies of SIC using the SPAR-4-SLR protocol. These were found in the Web of Science and Scopus databases and analyzed according to the TCCM framework. Our research provides new theoretical and managerial insights, advancing a consolidated original definition of SIC, reconciles and organizes factors in SIC’s nomological network advanced by disparate studies and synthesizes links between them in an integrating framework, and makes 13 propositions for advancing this topic based on the research gaps identified.
EYE MOVEMENTS OF DRIVERS IN URBAN TRAFFIC

The present investigation was related to the question of qualitative judgement patterns observed in drivers in urban traffic and the interaction between eye movement patterns and traffic environment. Five drivers were driving A stretch, in both directions, of a four lane and a two lane street in an urban setting. Simultaneously registrations with eye mark recordings (a nac-camera of corneal reflection type) and registrations of the traffic environment by camera pictures were made. The eye fixations were classified according to the type of objects the drivers were looking at. This method had the advantage that it also allowed for registrations of the occurrence of objects in the environment that the drivers were not looking at. A qualitative judgement of eye movements was facilitated using this registration technique and differences were found mainly to the extent attention was paid to pedestrians. More attention was paid to pedestrians in the two lane street than in the four lane street. (TRRL)
Design and Control of an Individualized Hip Exoskeleton Capable of Gait Phase Synchronized Flexion and Extension Torque Assistance

Assistive single-joint lower-limb exoskeletons have shown potential clinical benefits in patients with gait deficiencies. Torque-controlled exoskeletons, unlike position-controlled exoskeletons, do not restrict voluntary movements, allowing for safer interaction with the user. A torque-controlled hip flexion/extension exoskeleton intended for individuals with cerebral palsy is presented in this paper. The overarching research objective is to mitigate hip extension deficit and excessive hip flexion observed in crouch gait and apparent equinus gait patterns, which may be achieved by providing an extension torque during the stance phase. We expound on the design of an exoskeleton capable of performing this task, including a detailed discussion of the design, torque control, and benchmarking of its actuators. The device features series elastic actuators with a low output impedance and individualized orthotics designed using algorithmic 3D modeling and manufactured using additive manufacturing technologies. The exoskeleton’s mechanical structure, orthotics, control, user interface, and safety functions are presented. A performance evaluation was conducted through a trial on an unimpaired participant (174 cm, 74.5 kg). Up to 35 Nm of extension torque during stance could be achieved during walking on a treadmill with a stride time of 1.2 s. The participant was asked to simulate a crouched gait and experienced a lifting sensation at approximately 16 Nm of extension torque during stance, making it difficult to maintain the crouch.
Edukasi Pencegahan Filariasis dengan Buku Saku Mandiri di Wilayah Endemis Filariasis Kabupaten Demak

Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan dan praktek masyarakat dalam pencegahan filariasis. Metode yang digunakan adalah dengan edukasi dengan menggunakan media buku saku MANDIRI yang berisi informasi tertulis dilengkapi foto dan ilustrasi yang memuat langkah-langkah pencegahan filariasis. Buku saku ini telah memiliki ISBN dan diterbitkan oleh UNNES Press dan dari hasil penelitian terdahulu telah berhasil berperan dalam menurunkan angka Mf rate Kelurahan Bandengan Kota Pekalongan dari Mf rate 2,0% menjadi 0,0%. Buku ini diserahkan pada kelompok warga dan saling dipinjamkan decara bergilir sehingga dapat dibaca oleh seluruh warga. Diskusi antar warga dapat terjadi pada kesempatan saling meminjamkan buku tersebut. Kegiatan pengabdian dilaksanakan tanggal 5 Mei 2018 di Desa Sidogemah dan tanggal 12 Mei 2018 di Desa Bedono. Monitoring perguliran buku saku dilaksanakan tanggal 7 Juli di Desa Sidogemah dan tanggal 14 Juli di Desa Bedono. Perguliran buku di Desa Sidogemah 75% baik dan di Desa Bedono 80% baik. Keseluruhan dari masing-masing 20 orang peserta Desa Sidogemah dan Desa Bedono mengalami peningkatan skor pengetahuan. Peningkatan pengetahuan rata-rata Desa Sidogemah meningkat dari rata-rata pre test sebesar 6,25 menjadi rata-rata post test sebesar 11,25. Peningkatan pengetahuan rata-rata Desa Bedono meningkat dari rata-rata pre test sebesar 5,75 dan rata-rata post test sebesar 12,25.
Cold Atmospheric Pressure Plasma Jet and Plasma Lamp Interaction with Plants: Electrostimulation, Reactive Oxygen and Nitrogen Species, and Side Effects

Cold atmospheric pressure plasma (CAPP) treatment is a highly effective method of protecting seeds, plants, flowers, and trees from diseases and infection and significantly increasing crop yields. Here we found that cold atmospheric pressure He-plasma jet (CAPPJ) can also cause side effects and damage to plants if the plasma exposure time is too long. Reactive oxygen and nitrogen species (RONS), electromagnetic fields, and ultraviolet photons emitted by CAPPJ can cause both positive and negative effects on plants. CAPPJ can interact with biological tissue surfaces. The plasma lamp has no visible side effects on Aloe vera plants, cabbage, and tomatoes. A plasma lamp and a cold atmospheric pressure plasma He-jet cause strong electrical signaling in plants with a very high amplitude with frequencies equal to the frequency of plasma generation. The use of plasma lamps for electrostimulation of biological tissues can help to avoid side processes in biological tissues associated with the generation of RONS, UV photons, and direct interaction with cold plasma. CAPP technology can play an important role in agriculture, medicine, the food industry, chemistry, surface science, material science, and engineering applications without side effects if the plasma exposure is short enough.
Commentaries on Scientific Papers Published in this Edition

Objective To compare the use of the Aesthetic Component (AC) of IOTN and the Child Perceptions Questionnaire (CPQ) in assessing orthodontic treatment need and concern. Design Cross-sectional observational study Subjects and methods The subjects were 204 children aged 10–12 years studying in 10 schools in Bristol, UK. They completed a questionnaire comprising the CPQ and questions regarding orthodontic concern. AC scores as rated by the child and by the calibrated examiner were recorded. Main outcome measures CPQ scores were calculated from the responses in the questionnaire. AC scores and responses to questions regarding orthodontic concern were recorded. Results The children gave themselves lower AC scores compared to the examiner (p<0.001). The only section of the CPQ that correlated significantly with Examiner AC was the emotional impacts section (rho=0.151). CPQ scores had a slightly higher correlation with self-perceived AC than Examiner AC. However, the correlations were still very low. The emotional impacts section of CPQ (rho=0.332) and overall CPQ score (rho=0.282) were better than the examiner AC (rho=0.209) at reflecting how bothered the children were by the alignment of their teeth, and how upset they would be if they couldn't receive orthodontic treatment (rho=0.464, 0.428 and 0.214, respectively). Children with a normative need for orthodontic treatment, based on examiner AC did not have a worse oral health-related quality of life. Conclusion(s) The CPQ and IOTN AC measure different attributes. There should be a shift towards using quality of life measures to supplement the IOTN in assessing the perceived need for orthodontic treatment.
Topical proactive therapy in dermatology. A scoping review

The term ‘proactive therapy’ refers to a long-term management of clinically intact skin in previously disease-affected areas. This method was initially implemented in atopic dermatitis to maintain the remission and decrease the risk of exacerbations. Proactive therapy aims to limit the need for reactive treatment and improve the patients’ quality of life. A proactive approach is likely to be adopted for other relapsing and inflammatory skin conditions in the future. This scoping review aims to identify dermatological conditions to be treated with the proactive approach, evaluate the available evidence for its efficacy and safety, as well as highlight the research gaps.
Control of Tip Leakage Flow in Axial Flow Compressor Cascade by Suction on the Blade Tip

One of the important ways of improving axial compressor performance is to control the tip leakage flow near the endwall region. Numerical computations were conducted to investigate the impact of blade tip suction on the axial compressor cascade performance in current paper. Three suction schemes located on the blade tip with different chordwise coverage were investigated in total. The results show that the cascade overall performance can be effectively enhanced by the proper suction scheme on the blade tip and the best scheme should be arranged at slightly downstream of the onset point of the tip leakage vortex (TLV). The control effectiveness and mechanisms are different for the different suction schemes. For the suction scheme covering the starting point of TLV, the onset point of TLV is shifted downstream, while an additional induced leakage flow near the blade leading edge is generated resulting in the increase of mixing loss. It is more effective when the structure of the main TLV is destroyed and divided into different parts by applying the blade tip suction arranged slightly behind the onset point of TLV. In addition, the blade loading is redistributed near the blade tip after the blade tip suction and the total pressure loss caused by the suction slots should also be considered in the design process.
Influence of Ag and/or Sr Dopants on the Mechanical Properties and In Vitro Degradation of β-Tricalcium Phosphate-Based Ceramics

β-tricalcium phosphate has good biodegradability and biocompatibility; it is widely perceived as a good material for treating bone deficiency. In this research, different contents of strontium (Sr) and silver (Ag) ion-doped β-tricalcium phosphate powders were prepared using the sol–gel method. After obtaining the best ratio of pore-forming agent and binder, the as-synthesized powders were sintered in a muffle for 5 h at 1000 °C to obtain the samples. Then, these samples were degraded in vitro in simulated body fluids. The samples were tested using a series of characterization methods before and after degradation. Results showed that the amount of Sr and/or Ag doping had an effect on the crystallinity and structural parameters of the samples. After degradation, though the compressive strength of these samples decreased overall, the compressive strength of the undoped samples was higher than that of the doped samples. Notably, apatite-like materials were observed on the surface of the samples. All the results indicate that Sr and/or Ag β-TCP has good osteogenesis and proper mechanical properties; it will be applied as a prospective biomaterial in the area of bone repair.
Taxonomy of Various Routing Protocols of IoT-Based on Wireless Sensor Networks for Healthcare: Review

– In recent decades, the world's largest sector has undergone enormous transformations with the emergence of a new platform, denoted as 'healthcare' and based on the IoT (Internet of Things). Numerous hospital administrators are increasing their investment in converting existing activities to maximize the benefits of IoT, creating the foundation for the wireless healthcare system through a vast network of sensing devices and equipment. The wireless sensor system comprises minimal sensor equipment with limited processing capacity. IoT-based WSN systems are beneficial for smart healthcare. Healthcare has become one of the WSN (wireless sensor network)-based IoT application fields that have attracted much more attention from corporate, government sources, etc in the past few years. In the medical industry, the growth of IoT enhances patient safety, employee engagement, and productivity improvement for the overall system. Healthcare-based IoT wireless sensor systems for patients have several benefits: tracking and alerting, patient information management, remotely assisting the healthcare system, etc. In the context of wireless sensor healthcare systems utilizing Internet of Things (IoT) technology, the infrastructure encompasses a range of essential elements. These include sensing devices responsible for data collection, communication protocols facilitating data transmission, data storage devices for retaining collected information, and subscribers who access and utilize the acquired data. The IoT framework in healthcare systems comprises three fundamental components: the publisher, broker, and subscriber. The publisher is known for sensors and wearable devices. Brokers process the sensing data and then make it available to subscribers. The three components are connected via a wireless connection like Bluetooth, Wi-Fi, etc. The routing protocols are used for wireless connections in healthcare based on IoT systems. There are various categories of routing protocols used in the wireless healthcare network. This paper discusses various routing protocols with types, and comparison tables of routing protocols are depicted. A comprehensive review of healthcare-based IoT applications and an advanced medical care system benefits doctors and patients. The experts monitor ECG (electrocardiography), blood pressure, temperature, etc. The comparison of several methods based on throughput, E2D (end-to-end) delay, consumption, and data packet delay ratio (PDR) is depicted in this paper for a better understanding of the existing systems.
Integrin-Mediated Long-Term B Cell Retention in the Splenic Marginal Zone

The mechanisms that control localization of marginal zone (MZ) B cells are poorly understood. Here we show that MZ B cells express elevated levels of the integrins LFA-1 (αLβ2) and α4β1 and that they bind to the ligands ICAM-1 and VCAM-1. These ligands are expressed within the MZ in a lymphotoxin-dependent manner. Combined inhibition of LFA-1 and α4β1 causes a rapid and selective release of B cells from the MZ. Furthermore, lipopolysaccharide-triggered MZ B cell relocalization involves down-regulation of integrin-mediated adhesion. These studies identify key requirements for MZ B cell localization and establish a role for integrins in peripheral lymphoid tissue compartmentalization.
Distribution of the Tree of Heaven (Ailanthus altissima /Mill./ Swingle) and Spreading of Invasive Woody Alien Species in Croatia

Invazivni neofiti su strane biljne vrste koje su unesene namjerno ili slucajno izvan podrucja svoga prirodnog rasprostranjenja, tamo se nekontrolirano sire i prijetnja su bioloskoj raznolikosti, pri cemu mogu uzrokovati nepovratne stete. Oni su ozbiljna prijetnja autohtonim vrstama, biljnim zajednicama i ekosustavima u mnogim zemljama. U radu je prikazan problem sirenja invazivnih drvenastih neofita u Hrvatskoj, koji su podijeljeni u tri skupine. U prvoj skupini su vrste koje su se u proslosti vec prosirile na nova stanista, udomacile su se i uklopljene su u prirodnu vegetaciju (Robinia pseudoacacia L., Amorpha fruticosa L., Fraxinus pennsylvanica Marshall), u drugoj skupini su vrste koje se sire na nova podrucja (Ailanthus altissima /Mill./ Swingle, Acer negundo L.), a u trecoj skupini su potencijalno opasne vrste koje su u srednjoeuropskim i mediteranskim državama zabilježene kao invazivne (Broussonetia papyrifera (L.) Vent. , Buddleja davidii Franch. , Celtis occidentalis L. , Elaeagnus angustifolia L. , E. umbellata Thunb. , Gleditsia triacanthos L. , Lonicera japonica Thunb. , L. maackii (Rupr.) Maxim. , Maclura pomifera (Raf.) C. K. Schneid. , Mahonia aquifolium (Pursh) Nutt. , Melia azedarach L. , Parthenocissus quinquefolia (L.) Planch. , Paulownia tomentosa (Thunb. ex Murray) Steud. , Prunus serotina Ehrh. , Rhus typhina L. , Ulmus pumila L. i dr.). Prikazano je sadasnje stanje rasprostranjenosti pajasena (A. altissima) u Hrvatskoj, koji je najizrazitiji drvenasti neofit iz druge skupine. Na primjeru pajasena opisana su bioloska svojstva koja neofitima omogucuju lakse sirenje, ekoloske prijetnje toga sirenja, te mogucnost prevencije i kontrole.
Impact of Microfinance on Women Empowerment

Microfinance has proved its importance in relation to poverty eradication, financial development, rural finance, banking and financial services in India. Though the India had philanthropic philosophy to help each other and grow together, microfinance helped the same in a more institutional and organised manner. Indiais a diverse country in every aspect of human life which applies to its poverty too. Each region of India has its own language of poverty. Microfinance also puts forward the movement of financial inclusion of women across the community. Microfinance has come forward as a ray of hope for the women who are supposed to be equally participating in financial inclusion. The impact of microfinance in the area of women empowerment in India is still neglected and less documented concept especially in the spectrum of research.The present article is an outcome of literature review which clearly indicates the impact of microfinance movement in the process of women empowerment. The article has utilized qualitative as well as quantitative aspect to explore the impact of microfinance in the process of women empowerment.
The Impact of Advanced Maternal Age on Pregnancy Outcomes: A Retrospective Multicenter Study

The aim of this multicenter retrospective cohort study was to examine the impact of maternal age on perinatal outcomes in multiparas, stratified according to maternal age in one- and two-year increments. The analysis involved 302,484 multiparas who delivered between the years 2003 and 2021 in four university-affiliated obstetrics departments. Maternal age was considered both as a continuous variable and in two-year intervals, as compared with a comparison group of parturients aged 25–30 years. The study focused on cesarean delivery and neonatal intensive care unit (NICU) admission as primary outcomes. The findings revealed that cesarean delivery rates increased as maternal age advanced, with rates ranging from 6.7% among 25–30 year olds, rising continuously from 13.5% to 19.9% between the age strata of 31 and 42, to exceeding 20% among those aged ≥ 43 years (p < 0.01 for each stratum when compared to 25–30 year old group). Similarly, NICU admission rates rose from 2.7% in the comparison group to 6% in parturients aged 45–46 years (p < 0.01 for each stratum when compared to 25–30 year old group). The study highlights the association between incrementally advanced maternal age and increased rates of maternal and neonatal complications, necessitating global awareness of these implications for family planning decisions and maternal care.
Time-Domain Analysis and Optimization of a Three-Phase Dual-Active-Bridge Converter With Variable Duty-Cycle Modulation

The duty-cycle control (DCC) modulation scheme for the three-phase dual-active-bridge (3p-DAB) dc–dc converter is a promising three degree-of-freedom modulation scheme which can extend the converter's soft-switching range and reduce conduction losses under partial loading and wide voltage variations. However, the prior suggested methods to implement DCC in 3p-DABs have drawbacks, such as requiring a multifrequency approximation and offline optimization process, or achieving less than optimal efficiency. To overcome these challenges, this article first proposes an optimal DCC modulation strategy (OMS) for the 3p-DAB based on a novel piecewise time-domain analysis (TDA) and optimization process that obtains the optimal control parameters for minimum rms phase current. Second, this article proposes a novel closed-form minimum current stress optimization (MCSO) DCC scheme based on the theoretical findings of the TDA optimization. The MCSO reduces the transformer phase currents and extends soft-switching operation under partial loading and wide voltage variations. Experimental results show that the proposed closed-form MCSO DCC scheme has virtually identical efficiency as the OMS, making this the first article to provide a closed-form DCC modulation scheme for a 3p-DAB that achieves efficiency results equivalent to a fully optimized offline scheme, but without the drawbacks of the offline optimization process.