Miracle-dz/UniFAR-FTUs huggingface dataset:
CONTROL OF THE OPERATING TEMPERATURE OF A PHOTOVOLTAIC SYSTEM USING PID

The present article presents a study of the application of the strategy of control of the temperature of operation of a photovoltaic plate using a PID controller. The controller should keep the working temperature of the photovoltaic cells at around 30 degrees Celsius. For the development of this work the PID controller and graphical simulation, environments were used. The objective of this article is the study of the performance of the photocell based on the stabilization of the operating temperature, the simulation was performed through the software MATLAB and Simulink. The results show that it is possible to keep the temperature stable through forced ventilation and the experiment has relevance, since the temperature stabilization method is applicable in energy generation projects, where the ambient temperature is severe.
Behavioral Tagging: Role of Neurotransmitter Receptor Systems in Novel Object Recognition Long-Term Memory

Strong training is known to form long-term memory (LTM) as it is an inducer for both a learning tag (just like a synaptic tag/molecular tag) and plasticity-related proteins (PRPs), while weak training is an inducer of only a learning tag. However, weak training can also lead to LTM if paired with another behavioral task (open field in our study—a representative of a novel environment) around the time of PRP arrival. Weak behavioral training is a learning tag inducer, while the open field is a PRP inducer. The learning tag then captures these PRPs to form LTM. This is the basis of behavioral tagging (BT). BT is a well-known model for the evaluation of a few learning and memory forms. In this work, we examined the role of glutamate and D1/D5 (dopamine) receptors in the synthesis of a novel object recognition (NOR) tag (learning) as well as in PRP arrival, which come together to form NOR-LTM. Employing antagonists and/or agonists preceding or proceeding the open field and/or NOR training, it was revealed that the activation/stimulation of D1/D5 (dopamine) receptors and glutamatergic NMDA receptors plays a critical part in PRP arrival. We found that the activation/stimulation of NMDA receptors also contributes to the setting of the learning tag. Moreover, changes in glutamate, dopamine, and GABA neurotransmitter levels were also analyzed. These findings thus demonstrate the critical time window required for NOR-LTM formation based on the process of BT along with the role of activation/stimulation of D1/D5 (dopamine) receptors and NMDA receptors in the arrival of PRPs and learning tags for NOR-LTM formation.
The effect of controlling person’s illegalities on stock price returns: Evidence from Elman neural network model

Controlling persons are the ultimate decision-makers of listed companies. Their illegalities have impacts on investors’ wealth, firm development, and capital market’s quality. Against this backdrop, we provide a quantitative analysis of the short-term stock price reaction to the criminal detention announcements of controlling persons throughout 2007–2019. We applied the Elman neural network (ENN) model into the classical event study methodology and demonstrated that the combination of them helps to improve the estimation accuracy of the stock price reaction. The results show that the stock price has a significant negative reaction to the criminal detention announcements of listed companies’ controlling persons on the announcement day, and the average reaction level is -6.67%. Additionally, the crisis communication measures of the firms could diminish the negative impact of such mandatory disclosure information on their stock price, but the effect is limited. Finally, the 31 companies in our sample cause a total loss of RMB 21.1 billion in market capitalization on the announcement day alone. The above results indicate that the impact of listed companies’ controlling persons on the capital market is tremendous, although the number of this group is small. Our work enriches the listed companies’ illegalities research and provides a reference for investors’ investment choices and follow-up decision making of regulatory authorities. It also provides some guidance for most of the researchers to further explore the application of data mining techniques in nonlinear problems.
Relationship between lymphedema after breast cancer treatment and biophysical characteristics of the affected tissue

The treatment of breast cancer is often complicated by lymphedema of the upper limbs. Standard lymphedema evaluation methodologies are not able to measure tissue fibrosis. The ultrasound aspects related to tissue microstructures of lymphedema are neglected in clinical evaluations. The objective of this study was to identify and measure the degree of impairment, topography, and biophysical alterations of subcutaneous lymphedema tissue secondary to the treatment of breast cancer by ultrasonography. Forty-two women at a mean age of 58 (±9.7) years, with unilateral lymphedema due to breast cancer treatment, were evaluated. The upper limbs were divided into affected (affected by lymphedema) and control (contralateral limb). Each limb was subdivided into seven areas, defined by perimetry, evaluated in pairs. The biophysical characteristics thickness, entropy, and echogenicity were evaluated by ultrasonography. The results showed a significant difference in the echogenicity and thickness variables between the affected and unaffected upper limb, in all the extent of the upper limb, while entropy showed no significant difference. The findings indicate that the data presented were consistent both in identifying and measuring the degree of impairment and biophysical changes in the subcutaneous tissue of lymphedema secondary to the treatment of breast cancer.
Effect of intrinsic foot muscles training on foot function and dynamic postural balance: A systematic review and meta-analysis

This systematic review aimed to analyse the effects of intrinsic foot muscle (IFM) training on foot function and dynamic postural balance. Keywords related to IFM training were used to search four databases (PubMed, CINAHL, SPORTDiscus and Web of Science databases.) for relevant studies published between January 2011 and February 2021. The methodological quality of the intervention studies was assessed independently by two reviewers by using the modified Downs and Black quality index. Publication bias was also assessed on the basis of funnel plots. This study was registered in PROSPERO (CRD42021232984). Sixteen studies met the inclusion criteria (10 with high quality and 6 with moderate quality). Numerous biomechanical variables were evaluated after IFM training intervention. These variables included IFM characteristics, medial longitudinal arch morphology and dynamic postural balance. This systematic review demonstrated that IFM training can exert positive biomechanical effects on the medial longitudinal arch, improve dynamic postural balance and act as an important training method for sports enthusiasts. Future studies should optimise standardised IFM training methods in accordance with the demands of different sports.
Numerical study of trailing edge flow control for horizontal axis wind turbines

Wind turbines have been developed for more than a century and nowadays wind turbines are still facing some challenges such as efficiency and maintenance problems. Load control is considered to be one of the most important parts for future horizontal axis wind turbine (HAWT) designs. Deploying effective flow control devices on the blades could either increase loads at off-design wind speed conditions or reduce the extreme loads, leading to either higher energy output or a more stable energy output from the wind turbine. This study reports a research into the performance of trailing edge flow control devices of HAWT by solving the Reynolds averaged Navier-Stokes equations. The validation case selected for this work is the NREL Phase VI blade with experimental data. The trailing edge flow control devices studied include microtabs and microjets installed near the trailing edge of the rotating blade. The divergent trailing edge is also included in the study as a passive flow control device due to its practical interest. These trailing edge devices are implemented on the fixed-pitch NREL Phase VI blade, using the original performance and flow characteristics as a benchmark. Both 2D and 3D simulations are carried out in order to investigate the suitability of the 2D blade sectional design analysis and control for the actual 3D rotating framework. Moreover, the study is extended to an active pitch-regulated offshore wind turbine, NREW 5MW wind turbine. Firstly the code to code comparison is carried out for validation purpose. Then the trailing edge flow control devices are also deployed on this wind turbine to find out their effectiveness. The results show there are significant differences when compared to the conclusions from the CFD study on the NREL Phase VI blade
The Many Faces of a Virtual Team: A Review of Research Done on Individual Member Input to Virtual Teams

Extracted text; Over time, research on virtual teams has ventured down many paths. For example, themes like trust and virtuality have had extensive research done within the past decade. As time and society changes, new themes arise in virtual team research. In this review, literature about three themes of generational impacts, self-efficacy, and power dynamics from the past few years are examined. A few opportunities for future research stemming from these themes are then presented. With the constant shift toward technology in the workplace and more opportunities for large global projects, research on virtual teams continues to be vital in helping to determine what helps a virtual team’s success.
Evidence for top‐down metre perception in infancy as shown by primed neural responses to an ambiguous rhythm

From auditory rhythm patterns, listeners extract the underlying steady beat and perceptually group beats to form metres. While previous studies show infants discriminate different auditory metres, it remains unknown whether they can maintain (imagine) a metrical interpretation of an ambiguous rhythm through top‐down processes. We investigated this via electroencephalographic mismatch responses. We primed 6‐month‐old infants (N = 24) to hear a 6‐beat ambiguous rhythm either in duple metre (n = 13) or in triple metre (n = 11) through loudness accents either on every second or every third beat. Periods of priming were inserted before sequences of the ambiguous unaccented rhythm. To elicit mismatch responses, occasional pitch deviants occurred on either beat 4 (strong beat in triple metre; weak in duple) or beat 5 (strong in duple; weak in triple) of the unaccented trials. At frontal left sites, we found a significant interaction between beat and priming group in the predicted direction. Post‐hoc analyses showed that mismatch response amplitudes were significantly larger for beat 5 in the duple‐primed than triple‐primed group (p = .047) and were non‐significantly larger for beat 4 in the triple‐primed than duple‐primed group. Further, amplitudes were generally larger in infants with musically experienced parents. At frontal right sites, mismatch responses were generally larger for those in the duple compared with triple group, which may reflect a processing advantage for duple metre. These results indicate that infants can impose a top‐down, internally generated metre on ambiguous auditory rhythms, an ability that would aid early language and music learning.
Does the presence of physician-staffed emergency medical service improve the prognosis in out-of-hospital cardiac arrest? A propensity score matching analysis.

BACKGROUND Substantial differences in survival after out-of-hospital cardiac arrest (OHCA) have been observed between countries. These might be attributed to the organization of Emergency Medical Service (EMS) systems, including prehospital physician involvement. However, limited data exist on the physician's role in survival after OHCA. AIMS To compare prehospital and in-hospital outcomes of OHCA patients attended by physician-staffed EMS versus paramedic-staffed EMS units. METHODS Among all patients enrolled in the regional, prospective registry of OHCA in southern Poland, those aged <18, with unwitnessed or EMS-witnessed cardiac arrest, without attempted cardiopulmonary resuscitation (CPR), attended by more than one EMS, or with traumatic cardiac arrest, were excluded. The groups were matched 1:1 using propensity scores for baseline characteristics variables that might influence physician-staffed EMS dispatch. RESULTS A total of 812 OHCA cases were included in the current analysis. Among them, 351 patients were attended by physician-staffed EMS. There were no differences in baseline characteristics in the propensity-score matched cohort consisting of 351 pairs. The return of spontaneous circulation (ROSC) was more often achieved in the physician-staffed EMS group (42.7% vs. 33.3%; P = 0.01). The prehospital survival rate was also higher in this group (34.1% vs. 19.2%; P <0.01). However, there were no significant differences in survival rate to discharge between cases treated by physician-staffed and paramedic-staffed EMS (9.7% vs. 7.0%; P = 0.22). CONCLUSIONS OHCA patients attended by physician-staffed EMS were more likely to have ROSC and survive to hospital admission. However, better prehospital outcomes might not translate into improved in-hospital prognosis in these patients.
Mechano-chemical and biological energetics of immobilized enzymes onto functionalized polymers and their applications

ABSTRACT Enzymes of commercial importance, such as lipase, amylase, laccase, phytase, carbonic anhydrase, pectinase, maltase, glucose oxidase etc., show multifunctional features and have been extensively used in several fields including fine chemicals, environmental, pharmaceutical, cosmetics, energy, food industry, agriculture and nutraceutical etc. The deployment of biocatalyst in harsh industrial conditions has some limitations, such as poor stability. These drawbacks can be overcome by immobilizing the enzyme in order to boost the operational stability, catalytic activity along with facilitating the reuse of biocatalyst. Nowadays, functionalized polymers and composites have gained increasing attention as an innovative material for immobilizing the industrially important enzyme. The different types of polymeric materials and composites are pectin, agarose, cellulose, nanofibers, gelatin, and chitosan. The functionalization of these materials enhances the loading capacity of the enzyme by providing more functional groups to the polymeric material and hence enhancing the enzyme immobilization efficiency. However, appropriate coordination among the functionalized polymeric materials and enzymes of interest plays an important role in producing emerging biocatalysts with improved properties. The optimal coordination at a biological, physical, and chemical level is requisite to develop an industrial biocatalyst. Bio-catalysis has become vital aspect in pharmaceutical and chemical industries for synthesis of value-added chemicals. The present review describes the current advances in enzyme immobilization on functionalized polymers and composites. Furthermore, the applications of immobilized enzymes in various sectors including bioremediation, biosensor and biodiesel are also discussed. Graphical abstract
Expression of miRNA-1-3p and its target gene in hair follicle cycle development of Liaoning Cashmere goat

Abstract MicroRNA exerts an important regulatory role in almost all the biological process, including hair follicle development in Liaoning Cashmere goat. In order to improve the Cashmere performance of goat, the regulatory role of microRNA in hair follicle cycle has drawn hotspot attention. However, the molecular mechanisms of miRNA-1-3p involved in hair follicle development are poorly understood. In this study, we found that miRNA-1-3p was less expressed in anagen stage of hair follicle cycle of Cashmere goat than that in telogen stage by using RT-qPCR and immunoblotting analysis, in contrast to the expression pattern of FGF14. The Dual-Luciferase reporter assay was employed to verify the relationship between miRNA-1-3p and FGF14. The results showed that miRNA-1-3p specifically binds to the 3′UTR of FGF14 mRNA, and FGF14 is the target gene of miR-1-3p. In conclusion, this study shows that miRNA-1-3p may regulate hair follicle development in Liaoning Cashmere goats by targeting FGF14.
Correlation of Optical Coherence Tomography Angiography of Type 3 Macular Neovascularization With Corresponding Histology.

Importance By validating optical coherence tomography angiography (OCTA) in the analysis of type 3 macular neovascularization secondary to age-related macular degeneration, the overall value of clinical OCTA for disease observation, diagnosis, and staging is increased. Objective To assess the association of in vivo OCTA of type 3 macular neovascularization secondary to age-related macular degeneration with corresponding ex vivo histology. Design, Setting, and Participants This study included clinical imaging, laboratory microscopy, and eye-tracked clinicopathologic correlation of a single case from a community-based practice evaluated at a university-based research laboratory from 2014 to 2019. Exposures Infrared reflectance and eye-tracked spectral-domain OCTA clinical imaging was correlated with ex vivo high-resolution histologic images of the preserved donor eye. Eye tracking, applied to the donor eye, enabled identification of histologic features corresponding with clinical OCTA signatures. Projection artifact removal based on 2-dimensional vessel-shape estimation and a Gaussian blur filter demonstrated a robust preservation of neovascular flow signal. Main Outcomes and Measures Histology findings associated with clinical OCTA signatures. Three-dimensional view of neovascularization via video. Results A White woman in her 90s with type 3 neovascularization secondary to age-related macular degeneration was treated with 37 intravitreal injections of ranibizumab and aflibercept in the right eye. The index lesion displayed a drusenoid pigment epithelium detachment, characteristic of type 3 neovascularization. OCTA decorrelation signal in the index lesion corresponded in histology to a collagen-ensheathed vascular complex contacting basal laminar deposit that outlasted the retinal pigment epithelium. The subretinal pigment epithelium-basal laminar space contained calcified material and glial processes. No connection between the choriocapillaris and this space was observed. Video showed a columnar tangle of flow signal in the outer nuclear layer, with inflow and outflow vessels connecting to the superficial artery and vein. Conclusions and Relevance While this study presents only 1 case in which a vascular connection between subretinal pigment epithelium-basal laminar space and choriocapillaris was undetected, these results support the potential value of OCTA for diagnosis. OCTA decorrelation signal of type 3 neovascularization corresponded with intraretinal neovessels on histology. Projection artifact removal based on 2-dimensional vessel-shape estimation and Gaussian blur filter demonstrated their potential value for further use in OCTA decorrelation signal processing.
Reasons and predictors of non‐thrombolysis in patients with acute ischemic stroke admitted within 4.5 h

Thrombolytic treatment in acute ischemic stroke (AIS) reduces stroke‐related disability. Nearly 40% of all patients with AIS (<4.5 h) receive thrombolysis, but there is a large variation in the use between hospitals. Little is known about reasons and predictors for not giving thrombolytic treatment. Therefore, we aimed to investigate reasons for non‐thrombolysis in patients admitted within 4.5 h.
Genomic reaction norms inform predictions of plastic and adaptive responses to climate change

Abstract Genomic reaction norms represent the range of gene expression phenotypes (usually mRNA transcript levels) expressed by a genotype along an environmental gradient. Reaction norms derived from common‐garden experiments are powerful approaches for disentangling plastic and adaptive responses to environmental change in natural populations. By treating gene expression as a phenotype in itself, genomic reaction norms represent invaluable tools for exploring causal mechanisms underlying organismal responses to climate change across multiple levels of biodiversity. Our goal is to provide the context, framework and motivation for applying genomic reaction norms to study the responses of natural populations to climate change. Here, we describe the utility of integrating genomics with common‐garden‐gradient experiments under a reaction norm analytical framework to answer fundamental questions about phenotypic plasticity, local adaptation, their interaction (i.e. genetic variation in plasticity) and future adaptive potential. An experimental and analytical framework for constructing and analysing genomic reaction norms is presented within the context of polygenic climate change responses of structured populations with gene flow. Intended for a broad eco‐evo readership, we first briefly review adaptation with gene flow and the importance of understanding the genomic basis and spatial scale of adaptation for conservation and management of structured populations under anthropogenic change. Then, within a high‐dimensional reaction norm framework, we illustrate how to distinguish plastic, differentially expressed (difference in reaction norm intercepts) and differentially plastic (difference in reaction norm slopes) genes, highlighting the areas of opportunity for applying these concepts. We conclude by discussing how genomic reaction norms can be incorporated into a holistic framework to understand the eco‐evolutionary dynamics of climate change responses from molecules to ecosystems. We aim to inspire researchers to integrate gene expression measurements into common‐garden experimental designs to investigate the genomics of climate change responses as sequencing costs become increasingly accessible.
The natural source, physicochemical properties, biological activities and metabolism of astilbin

Abstract Astilbin is a dihydroflavanol found in many plants and processed foods. Astilbin possesses multiple health-beneficial bioactivities and has received great attention. Hence, the natural source, physicochemical properties, biological activities and metabolism of astilbin are summarized in the present article. Engelhardia roxburghiana Wall. and Smilax glabra Roxb. are the main resource for astilbin purification because of high content. Because of chemical instability, astilbin amount in foods is dependent on the processing and storage conditions. The degradation of astilbin includes isomerization and decomposition. The interconversion of astilbin and its isomers occurs through a chalcone intermediates, which significantly affects the taste of wine during storage. Many factors such as temperature, pH, metal ions and food additives could affect the chemical stability of astilbin. Astilbin exhibits very novel selective immunosuppressive activity, which is not found in other compounds. The rhamnose moiety of astilbin is essential for this bioactivity. After digestion, astilbin was mainly absorbed and transported in circulatory blood in its intact form, and only one metabolite, 3′-O-methylastilbin, was found. Although having many bioactivities, astilbin faces the challenge of poor bioavailability. Some promising strategies were developed for improving its bioavailability, particularly through fabrication the zein nanoparticles.