Miracle-dz/UniFAR-FTUs huggingface dataset:
Comprehensive Analysis of Soluble Mediator Profiles in Congenital CMV Infection Using an MCMV Model

Congenital human cytomegalovirus (HCMV) infection may cause life-threatening disease and permanent damage to the central nervous system. The mouse model of CMV infection is most commonly used to study mechanisms of infection and pathogenesis. While essential to limit mouse CMV (MCMV) replication, the inflammatory responses, particularly IFNγ and TNFα, cause neurodevelopmental abnormalities. Other soluble mediators of the immune response in most tissues remain largely unexplored. To address this gap, we quantified 48 soluble mediators of the immune response, including 32 cytokines, 10 chemokines, 3 growth factors/regulators, and 3 soluble receptors in the spleen, liver, lungs, and brain at 9 and 14 days postinfection (dpi). Our analysis found 25 induced molecules in the brain at 9 dpi, with an additional 8 showing statistically elevated responses at 14 dpi. Specifically, all analyzed CCL group cytokines (CCL2, CCL3, CCL4, CCL5, CCL7, and CCL11) were upregulated at 14 dpi in the brain. Furthermore, data revealed differentially regulated analytes across tissues, such as CCL11, CXCL5, and IL-10 in the brain, IL-33/IL-33R in the liver, and VEGF-a and IL-5 in the lungs. Overall, this study provides an overview of the immune dynamics of soluble mediators in congenital CMV.
Potentiel de la télédétection pour l'analyse des propriétés optiques du système océan-atmosphère et application à l'estimation de la photosynthèse phytoplanctonique

La teledetection optique est un outil precieux pour l'etude des ecosystemes marins. L'utilisation quantitative des series temporelles obtenues et la coherence de series issues de capteurs differents sont conditionnees par un necessaire travail de validation, des produits primaires radiometriques jusqu'aux elaborations en termes de stocks et taux biologiques. Les sorties d'un code de restitution des effets atmospheriques, utilisant les donnees SeaWiFS pour la determination des proprietes optiques de la surface marine, sont analysees avec des mesures coincidentes recueillies a un site en Adriatique Nord. Les resultats sont mis en perspective avec ceux obtenus avec un code independant et d'autres capteurs (MODIS et MERIS). L'analyse est completee par la comparaison des caracteristiques d'aerosols prevues par le code avec les mesures provenant d'un reseau d'instruments. Une application des produits satellitaux de biomasse, combines avec une distribution spectrale de l'eclairement solaire a la surface, est l'estimation de la production primaire de l'ocean global. Le code de calcul de la production primaire inclut la modelisation de la propagation spectrale de la lumiere dans la colonne d'eau et son utilisation par le phytoplancton par l'intermediaire d'une relation photosynthese-lumiere. Les parametres de celle-ci ainsi que la structure verticale de la colonne d'eau sont definis par saison et par province biogeochimique. La comparaison avec les sorties de deux autres modeles de production primaire de reference fournit une premiere indication des incertitudes liees a ce genre d'estimations: un relatif accord en bilans globaux cache de fortes disparites spatio-temporelles. Une comparaison des sorties des modeles avec des mesures caracteristiques de divers sites permet de discuter certaines des sources d'incertitude.
Exploring discontinuous intentions of social media users: a cognition-affect-conation perspective

Introduction Drawing on the cognition-affect-conation (C-A-C) framework, this study investigates how perceived information and social and system feature overload induce depression and anxiety, which leads to affect discontinuous intentions of the social media users. Methods The data collected from 570 social networking site users in China are analyzed through structural equation modeling (SEM). Results and Discussion The findings show that perceived information overload, perceived social overload, and perceived system feature overload directly affect depression and anxiety among social networking site users, which directly leads to discontinuous intentions. This study fulfills the identified need for an in-depth investigation of discontinuous behavior in social networking sites. The findings provide social networking site providers with guidelines on how to actively manage social networking site user’s behavior to reduce the effects of negative emotions on social networking sites.
Weed control increases growth, cumulative yield, and economic returns of machine-harvested organic trailing blackberry

A trailing blackberry planting was established at Oregon State University’s North Willamette Research and Extension Center (Aurora, OR, USA) in 2010 to evaluate cultivar and weed management practices for a machine-harvested, processed fruit market. The planting was 0.4 ha in size and was certified organic (Oregon Tilth) in 2012, prior to the first harvest. Treatments studied were cultivar (‘Marion’ and ‘Black Diamond’) and in-row weed management [non-weeded, hand-weeded, and a porous, polyethylene ground cover (weed mat)] during establishment and three fruiting seasons (2012-2014). On average, plants growing in hand-weeded and weed mat plots produced 50% more primocanes than those in non-weeded plots, but the resulting floricane biomass was 50% higher in weed mat plots than either handweeded or non-weeded plots. This difference in plant growth response to the weed management treatments led to weed mat plots producing 36.1 t ha-1 of cumulative yield, 25 and 100% greater than the hand-weeded and non-weeded plots, respectively. Weed control (either with hand-weeding or weed mat) increased average berry weight compared to the non-weeded plots. Weed mat required a high initial investment to install, but only 16 h ha-1 to maintain over the study period (labor was valued at US$ 15 h-1). The non-weeded and hand-weeded treatments required 25 and 215 h ha-1 of labor to mow tall weeds prior to harvest or hand hoe, respectively. Total cumulative costs, including materials and installation (weed mat) over the 5 years were US$ 3,302 ha-1 for weed mat, US$ 3,231 ha-1 for hand-weeded, and US$ 370 ha-1 for non-weeded. Despite the relatively low cost of the non-weeded management strategy, low yield significantly reduced net returns (gross fruit sales – weed management costs). The hand-weeded and weed mat management strategies increased net returns by 40 and 71% compared to non-weeded, respectively. Weed mat had a 22% greater cumulative net return than the hand-weeded treatment. Weed mat increased growth, yield, and net returns and appears to be an excellent option for weed management in machine-harvested organic trailing blackberry.
Poor serum uric acid control increases risk for developing hypertension: a retrospective cohort study in China

Background Serum uric acid (SUA) has been suggested as a contributor of hypertension. However, reports on the relationship between changes in SUA and hypertension are limited. Hence, we aimed to investigate the potential impact of SUA, especially its change over time, on hypertension incidence. Methods This dynamic cohort included 6052 participants without hypertension at baseline. Participants were categorized into six grades based on whether baseline SUA was high and whether changes in SUA progressed to hyperuricemia or decreased to normal levels. Grades 1 to 6 represented the participants’ SUA control from best to worst. Logistic regression and restricted cubic spline (RCS) models were used to explore the association of the grades of SUA control and hypertension incidence. Results During a median follow-up of 6 years, 2550 (42.1%) participants developed hypertension. After adjusting confounding factors, compared to grade 1 with the best control of SUA, the odds ratios for grades 2 to 6 with worse control were 1.347 (1.109-1.636), 1.138 (0.764-1.693), 1.552 (1.245-1.934), 1.765 (1.170-2.663), and 2.165 (1.566-2.993), respectively. RCS indicated a linear correlation between the risk of hypertension and changes in SUA, and an elevated risk in participants with baseline hyperuricemia. Subgroup analyses showed that grades of SUA control had an interaction with systolic (P = 0.003) and diastolic blood pressure (P < 0.001). Sensitivity analyses further determined the robustness of the result that participants with poor SUA control have a higher risk of developing hypertension. Conclusion Poor SUA control, an increase in SUA over time, rises the risk of developing hypertension regardless of whether the initial SUA is normal or not. Initial hyperuricemia will exacerbate this risk. Effective SUA control should be an important measure for primary prevention of hypertension.
The Role of Tree Mortality in Vitality Assessment of Sessile Oak Forests

DOI: https://doi.org/10.15177/seefor.16-14 (1) University of West Hungary, Institute of Environmental and Earth Sciences, Bajcsy-Zsilinszky 4. , H-9400 Sopron, Hungary; (2) National Agricultural Research and Innovation Centre, Forest Research Institute, Várkerület 30/A, H-9600 Sárvár, Hungary; (3) National Food Chain Safety Office, Keleti Károly 24. , H-1024 Budapest, Hungary * correspondence: e-mail: rasztovitse@erti.hu © 2016 by the Croatian Forest Research Institute. This is an Open Access paper distributed under the terms of the Cr ative Commons Attribution License (http://creativecommons.org/licenses/by/4.0). Citation: BERKI I, RASZTOVITS E, MÓRICZ N, KOLOZS L 2016 The Role of Tree Mortality in Vitality Assessment of Sessile Oak Forests. South-east Eur for 7 (2): 91-97. DOI: https:// doi.org/10.15177/seefor.16-14 Received: 13 Jun 2016; Revised: 1 Sep 2016; 9 Nov 2016; Accepted: 10 Nov 2016; published online: 28 Nov 2016 Background and purpose: The drought-induced vitality loss of sessile oak (Quercus petraea (Matt.) Liebl. ) has been continuously observed in Hungary for more than three decades. The decrease in stand density as a consequence of drought-induced mortality has not been taken into consideration in most of the monitoring methods. Materials and Methods: Forest stands without any forest intervention during the last 30 years were selected. Quadrats were designated for the analysis in 18 sessile oak stands along a climatic transect in which foliage transparency and stand density were measured. Drought stress was defined by the water balance approach. By combining the foliage transparency and the relative stand density, a new cumulative assessment method of stand level vitality was introduced to get a more realistic picture about the effects of long-term drought (lasting for several decades) on the sessile oak forests in South-East
Globalizzazione e convergenza dei sistemi agro-alimentari delle economie

Questo saggio propone un’analisi empirica dell’evoluzione di lungo periodo dei sistemi agro-alimentari mondiali. Con una prospettiva piu ampia rispetto agli studi esistenti, che focalizzano prevalentemente il processo di convergenza in termini di produttivita, ci si propone di valutare l’evoluzione di un ampio set di variabili strutturali in grado di cogliere la dimensione sistemica del processo produttivo agro-alimentare. In particolare, partendo da un’analisi dei processi di lungo di periodo in atto nei sistemi agro-alimentari si applicheranno, sotto il vincolo della disponibilita di informazioni statistiche, alcune metodologie quantitative per l’analisi dei processi di convergenza economica. Cio al fine di testare empiricamente l’ipotesi che negli ultimi quattro decenni si sia assistito ad un processo di convergenza dei caratteri strutturali dei sistemi agroalimentari delle economie industriali avanzate (Paesi OECD ad alto reddito). Dinamica che si contrappone alla sostanziale stabilita nei caratteri strutturali dell’insieme dei 108 paesi del mondo per cui sono disponibili informazioni quantitative. In questo senso e possibile parlare di una tendenza di lungo periodo alla formazione di un “convergence club” dei sistemi agro-alimentari dei paesi avanzati. L’utilizzo dell’analisi in componenti principali relativa a diversi intervalli di tempo consente, inoltre, di tracciare una “mappa” dei paesi che via via sono entrati nel “convergence club” e di costruire un “indice del grado di arretratezza” di ciascun sistema agro-alimentare. Tali risultati forniscono importanti indicazioni in merito all’evoluzione dei sistemi agroalimentari all’avanzare del processo di sviluppo dell’economia fornendo utili spunti per l’interpretazione delle dinamiche di lungo periodo in atto sia nei paesi industriali avanzati che in quelli che si avviano a diventarlo.
Development of an activatable far-red fluorescent probe for rapid visualization of hypochlorous acid in live cells and mice with neuroinflammation

Recent investigations have suggested that abnormally elevated levels of HOCl may be tightly related to the severity of neuroinflammation. Although some successes have been achieved, fluorescent probes with far-red fluorescence emission and capable of detecting HOCl with high specificity in pure aqueous solution are still urgently needed. Herein, a responsive far-red fluorescent probe, DCI-H, has been constructed to monitor HOCl activity in vivo and in vitro. DCI-H could rapidly respond to HOCl within 120 s and had a low detection limit for HOCl of 1.5 nM. Importantly, physiologically common interfering species, except for HOCl, did not cause a change in the fluorescence intensity of DCI-HOCl at 655 nm. The results of confocal imaging demonstrated the ability of DCI-H to visualize endogenous HOCl produced by MPO-catalyzed H2O2/Cl− and LPS stimulation. With the assistance of DCI-H, upregulation of HOCl levels was observed in the mice model of LPS-induced neuroinflammation. Thus, we believed that DCI-H provided a valuable tool for HOCl detection and diagnosis of inflammation-related diseases.
Light response of leaf physiological parameters of Alhagi sparsifolia Shap. under different groundwater depths

To explore the effects of groundwater level variation on growth of the seedlings of Alhagi sparsifolia Shap,this study conducted a simulative experiment.Under different groundwater depths,we measured a series of leaf physiological parameters of the seedlings of Alhagi sparsifolia Shap,such as net photosynthetic rate(Pn),transpiration rate(Tr),water use efficiency(WUE) and photosynthetically active radiation(PAR)) by Li-6400 in southern fringe of the Taklimakan Desert in September,2008.Results show that:(1) Pn,Tr and WUE of the seedlings of Alhagi sparsifolia Shap.increase rapidly with PAR increasing under different groundwater depths at range of light intensity(0~1 000 μmol·m-2·s-1). Then,with the light intensity further increasing(1 000-2 500 μmol·m-2·s-1),we did not find Pn change with PAR increasing and the photo-inhibition was insignificant.The change tendencies of Tr and WUE were like that of Pn. (2) With groundwater depths decreasing(1,1.5,2.0,2.5 m),Tr,light saturation points(LSP),apparent quantum yield(AQY) and Pn increase while light compensation points(LCP) decrease.This phenomenon indicates that the photosynthetic capacity of A.sparsifolia increases significantly under certain groundwater depth.This paper will supply theoretical bases for studies on physiological response and adaptive mechanism of A.sparsifolia to groundwater depths and providing references for vegetation restoration on southern fringe of the Taklimakan Desert.
Effects of low quality soil, drought and systemic pesticides on plant flowering traits in Brassica Napus L.

One of the most important ecosystem services is animal pollination, which has been found to increase both crop quantity and quality and hence is important for sustainable food production. To provide food to an increasing population, farming systems are intensifying to maintain high crop yields. However, stressors such as climate change and intensified agricultural production schemes may alter plant flowering traits important for pollinator attraction, with the potential consequence of reducing pollination services. In this study, plants of rapeseed (Brassica napus L.) were exposed to drought, low soil quality and the neonicotinoid clothianidin, a systemic pesticide. Responses in plant flowering traits including nectar and pollen production, size and number of flowers, time before flowering and water content in pollen were measured to find individual or combined treatment effects. My results show that low soil quality in combination with drought reduced pollen and flower production, in addition to this, pesticide treatment in combination with low soil quality seem to increase the production of pollen. Flower production were reduced by both low soil quality and drought as individual factors, suggesting that the plant adapt by primarily reducing the number of flowers rather than reducing traits such as nectar and pollen quantity on each flower. The other plant traits investigated did not show a treatment response. Negative effects from reduced resources important for foraging may decrease pollinator attraction, consequently reducing seed yield.
Time-delay estimation in biomechanical stability: a scoping review

Despite its high-level of robustness and versatility, the human sensorimotor control system regularly encounters and manages various noises, non-linearities, uncertainties, redundancies, and delays. These delays, which are critical to biomechanical stability, occur in various parts of the system and include sensory, signal transmission, CNS processing, as well as muscle activation delays. Despite the relevance of accurate estimation and prediction of the various time delays, the current literature reflects major discrepancy with regards to existing prediction and estimation methods. This scoping review was conducted with the aim of characterizing and categorizing various approaches for estimation of physiological time delays based on PRISMA guidelines. Five data bases (EMBASE, PubMed, Scopus, IEEE and Web of Science) were consulted between the years of 2000 and 2022, with a combination of four related categories of keywords. Scientific articles estimating at least one physiological time delay, experimentally or through simulations, were included. Eventually, 46 articles were identified and analyzed with 20 quantification and 16 qualification questions by two separate reviewers. Overall, the reviewed studies, experimental and analytical, employing both linear and non-linear models, reflected heterogeneity in the definition of time delay and demonstrated high variability in experimental protocols as well as the estimation of delay values. Most of the summarized articles were classified in the high-quality category, where multiple sound analytical approaches, including optimization, regression, Kalman filter and neural network in time domain or frequency domain were used. Importantly, more than 50% of the reviewed articles did not clearly define the nature of the estimated delays. This review presents and summarizes these issues and calls for a standardization of future scientific works for estimation of physiological time-delay.
Progress in Biomarkers Related to Biliary Atresia

Biliary atresia (BA) is a congenital cholestatic disease that can seriously damage children’s liver function. It is one of the main reasons for liver transplantation in children. Early diagnosis of BA is crucial to the prognosis of patients, but there is still a lack of reliable non-invasive diagnostic methods. Additionally, as some children are in urgent need of liver transplantation, evaluating the stage of liver fibrosis and postoperative native liver survival in children with BA using a straightforward, efficient, and less traumatic method is a major focus of doctors. In recent years, an increasing number of BA-related biomarkers have been identified and have shown great potential in the following three aspects of clinical practice: diagnosis, evaluation of the stage of liver fibrosis, and prediction of native liver survival. This review focuses on the pathophysiological function and clinical application of three novel BA-related biomarkers, namely MMP-7, FGF-19, and M2BPGi. Furthermore, progress in well-known biomarkers of BA such as gamma-glutamyltransferase, circulating cytokines, and other potential biomarkers is discussed, aiming to provide a reference for clinical practice.
Model-Informed Drug Development: In Silico Assessment of Drug Bioperformance following Oral and Percutaneous Administration

The pharmaceutical industry has faced significant changes in recent years, primarily influenced by regulatory standards, market competition, and the need to accelerate drug development. Model-informed drug development (MIDD) leverages quantitative computational models to facilitate decision-making processes. This approach sheds light on the complex interplay between the influence of a drug’s performance and the resulting clinical outcomes. This comprehensive review aims to explain the mechanisms that control the dissolution and/or release of drugs and their subsequent permeation through biological membranes. Furthermore, the importance of simulating these processes through a variety of in silico models is emphasized. Advanced compartmental absorption models provide an analytical framework to understand the kinetics of transit, dissolution, and absorption associated with orally administered drugs. In contrast, for topical and transdermal drug delivery systems, the prediction of drug permeation is predominantly based on quantitative structure–permeation relationships and molecular dynamics simulations. This review describes a variety of modeling strategies, ranging from mechanistic to empirical equations, and highlights the growing importance of state-of-the-art tools such as artificial intelligence, as well as advanced imaging and spectroscopic techniques.
Factors Associated with Anemia and Iron Deficiency during Pregnancy: A Prospective Observational Study in Japan

Gestational anemia (GA) is a global health concern with a remarkably high prevalence in Japan, which is associated with various maternal and neonatal outcomes. This study aimed to explore whether GA and non-anemic iron deficiency (NAID) during the third trimester is associated with maternal characteristics, nutrient intake, low birth weight (LBW), and preterm birth. Participants were categorized into GA, NAID, and normal groups, based on serum ferritin and hemoglobin levels. Nutrient intake was assessed using the Brief Diet History Questionnaire. Data from 317 pregnant women were analyzed, including 110 (34.7%), 151 (47.6%), and 56 (17.6%) women in the GA, NAID, and normal groups, respectively. Factors associated with GA included being multipara (p < 0.001) and not taking any type of iron supplements in the third trimester (p = 0.043). The normal group had a significantly higher proportion of preterm birth and LBW than the GA and NAID groups. The GA group had a significantly higher energy intake than the normal group (p = 0.044). Overall, energy and micronutrient intake were significantly below the estimated average requirement in the dietary reference intakes for Japanese. Health care professionals need to consider nutritional advice that can prevent GA by focusing on overall micronutrients, not just energy intake.
Targeting the nucleic acid oxidative damage repair enzyme MTH1: a promising therapeutic option

The accumulation of reactive oxygen species (ROS) plays a pivotal role in the development of various diseases, including cancer. Elevated ROS levels cause oxidative stress, resulting in detrimental effects on organisms and enabling tumors to develop adaptive responses. Targeting these enhanced oxidative stress protection mechanisms could offer therapeutic benefits with high specificity, as normal cells exhibit lower dependency on these pathways. MTH1 (mutT homolog 1), a homolog of Escherichia coli’s MutT, is crucial in this context. It sanitizes the nucleotide pool, preventing incorporation of oxidized nucleotides, thus safeguarding DNA integrity. This study explores MTH1’s potential as a therapeutic target, particularly in cancer treatment, providing insights into its structure, function, and role in disease progression.