Miracle-dz/UniFAR-FTUs huggingface dataset:
Doppler Ultrasound in Prediction and Follow up of Copper 380 IUCD Induced Excessive Menstrual Bleeding

Objectives: This research aimed to evaluate Doppler Ultrasound value in prediction and follow up of copper 380 intrauterine contraceptive device (IUCD) induced excessive menstrual bleeding. Patients and methods: This was a prospective study performed on a total of 120 cases seeking 380 IUCD insertion. All the cases were subjected to 1) Full history taking, 2) General examination, 3) pelvic examination, 4) Abdominal exam, 5) Speculum examination to detect and exclude any bleeding local cause as erosion and polyp, 6) Menstrual history, 7) Obstetric history and 8) Doppler US. Results: Uterine artery resistance index (RI) and pulsatility index (PI) before and after IUD were negatively correlated with IUCD induced bleeding (P < 0.001). The RI and PI of sub-endometrium prior and following IUD were negatively correlated with the IUCD induced bleeding (P < 0.001) while visual field index (VFI) and vascularization index (VI) before and after IUD were positively correlated with the IUCD induced bleeding (P < 0.001). Also, endometrium flow index (FI), VFI and VI before and after IUD were positively correlated with the IUCD induced bleeding (P < 0.001). The uterine artery RI and PI prior and following IUD were negatively correlated with the IUCD induced bleeding (P < 0.001). Conclusions: Medical professionals should give women unbiased information on the potential variations in bleeding they may face if there is no extremely successful medication for excessive bleeding in the first few months following copper IUD placement.
Information-Entropic Method: Stability of Stars and Modified Gravity Theories

We study the stability of non-relativistic polytropic stars within two modified gravity theories i.e., Beyond Horndeski gravity and Eddington inspired Born Infeld theories using the configuration entropy method. We use spatially localized bounded function of energy density as solutions from stellar effective equations to construct the corresponding configuration entropy. We use the same argument as the one used by the authors of Refs. [1,2] that the stars are stable if there is peak in configuration entropy as a function of adiabatic index curve. Specifically, the boundary between stable and unstable regions which corresponds to Chandrasekhar stability bound is indicated from the existence of the maximum peak while the most stable polytropic stars is indicated by minimum peak in the corresponding curve. We have found that the value of critical adiabatic indexes of Chandrasekhar stability bound and the most stable polytropic stars predicted by non-relativistic limit of Beyond Horndeski Gravity and Eddington inspired Born Infeld theories are different to those predicted by general relativity where the corresponding differences depend on the free parameter of both theories.
R A ] 2 7 A pr 2 01 3 Representations and module-extensions of hom 3-Lie algebras

In this paper, we study the representations and module-extensions of hom 3-Lie algebras. We show that a linear map between hom 3-Lie algebras is a morphism if and only if its graph is a hom 3-Lie subalgebra and show that the derivations of a hom 3-Lie algebra is a Lie algebra. Derivation extension of hom 3-Lie algebras are also studied as an application. Moreover, we introduce the definition of Tθ-extensions and T ∗ θ -extensions of hom 3-Lie sub-algebras in terms of modules, provide the necessary and sufficient conditions for 2k-dimensional metric hom 3-Lie algebra to be isomorphic to a T ∗ θ -extensions.
Association of Common Variants of APOE, CETP, and the 9p21.3 Chromosomal Region with the Risk of Myocardial Infarction: A Prospective Study

The individual risk of an unfavorable cardiovascular outcome is determined by genetic factors in addition to lifestyle factors. This study was aimed at analyzing possible associations of several genetic factors with the risk of myocardial infarction (MI). For our study, we selected genes that have been significantly associated with MI in meta-analyses: the chromosomal region 9p21.3, the CETP gene, and the APOE gene. In total, 2286 randomly selected patients were included. Rs708272 and rs429358 and rs7412 were analyzed using RT-PCR via the TaqMan principle, and rs1333049 vas analyzed via a commercial KASP assay. In our sample, the frequencies of alleles and genotypes were consistent with frequencies in comparable populations of Eastern and Western Europe. Allele C of rs1333049 was significantly associated with MI among males (p = 0.027) and in the whole study sample (p = 0.008). We also revealed a significant association of the ɛ2/ɛ4 genotype of APOE with MI among males (p < 0.0001) and in the whole study sample (p < 0.0001). Thus, among the tested polymorphisms, some genotypes of rs1333049 and rs429358 and rs7412 are the most strongly associated with MI and can be recommended for inclusion into a genetic risk score.
Expectorant Effects of Immature Asian Pear Extract on PM2.5-Induced Subacute Pulmonary Injury in Mice

This study investigated the expectorant effects of immature Asian pear extract (IAP; Pyrus pyrifolia Nakai) on subacute pulmonary injuries in Balb/c mice induced by particulate matter with a diameter of approximately 2.5 μm (PM2.5). IAP was administered at three doses, namely, 400, 200, and 100 mg/kg. The body weight and weight gain changes, lung weights, lung and body surface gross inspections, tracheal secretions, and substance P and ACh content in lung tissue homogenate were observed one day after the tenth IAP administration. The mRNA expression of the genes related to mucus production and lung histopathology was compared with that of the negative and positive controls. Favorable pulmonary protective effects on PM2.5-induced subacute pulmonary injuries, mucus overproduction, and respiratory acidosis were observed in groups treated with IAP at all three doses, possibly through potent anti-inflammatory and mucolytic expectorant activities mediated by the increase in the content of lung substances P and ACh and the downregulation of lung MUC5AC and MUC5B mRNA expression in a dose-dependent manner. The results of this study show that an appropriate oral administration of IAP has sufficient pulmonary protective effects and can be used as a candidate for the development of functional food ingredients.
Quality of Mitral Valve Surgery Does Not Differ by Hospital Volume in New Jersey

Background and Aim of the Study. To investigate if mitral valve (MV) surgery quality differs by hospital volume in New Jersey (NJ). Methods. Using the NJ State Inpatient Database, patients ≥18 years undergoing MV repair or replacement from 2016–2019 were identified. Centers were considered high-volume if they performed more than 50 mitral operations annually. Baseline characteristics and outcomes (in-hospital mortality, seven-day readmission, hospital length of stay (LOS), and postoperative complications) were evaluated for the population and by center volume. Subanalysis by center volume within each procedure was conducted. Results. Among 2,560 mitral operations, MV replacement (92.3% (n = 2,362)) was performed more often than repair. High- (4) and low-volume (15) centers performed 1,180 (46.1%) and 1,380 (53.9%) mitral surgeries, respectively. Charlson Comorbidity Indices did not differ by center volume, including in subgroup analyses. Low-volume centers had higher rates of Hispanic patients, low-income patients, and readmission rates. High-volume centers had more transfers, urgent/emergent admissions, higher rates of in-hospital mortality, and longer LOS. Postoperative complications did not differ by volume. The MV replacement cohort reflected many of the differences seen in the total population, in addition to seeing higher rates of heart failure at high-volume centers and stroke at low-volume centers. Within MV repairs, significantly more Hispanic patients presented to low-volume centers and high-volume centers had longer LOS. Multivariable analysis indicated that hospital volume was not correlated to in-hospital mortality for the total population and within each procedure. Conclusions. MV replacement is performed more frequently than repair. Hospital volume is not correlated with MV surgical quality, and more representative quality measures are needed.
Explicit habit-prediction in the Lagrangian super-particle ice microphysics model McSnow

The Monte-Carlo ice microphysics model McSnow is extended by an explicit habit prediction scheme, combined with the hydrodynamic theory of \citeauthor{Boehm1992a}. \citeauthor{Boehm1992a}’s original cylindrical shape assumption for prolates is compared against recent lab results, showing that interpolation between cylinder and prolate yields the best agreement. For constant temperature and supersaturation, the predicted mass, size, and density agree well with the laboratory results, and a comparison with real clouds using the polarizability ratio shows regimes capable of improvement. An updated form of the inherent growth function to describe the primary habit growth tendencies is proposed and combined with a habit-dependent ventilation coefficient. The modifications contrast the results from general mass size relations and significantly impact the main ice microphysical processes. Depending on the thermodynamic regime, ice habits significantly alter depositional growth and affect aggregation and riming.
How to discover dissipative PDEs from particles? Particle fluctuations determine evolution operator

Dissipative processes abound in most areas of sciences and can often be abstractly written as $\partial_t z = K(z) \delta S(z)/\delta z$, which is a gradient flow of the entropy $S$. Although various techniques have been developed to compute the entropy, the calculation of the operator $K$ from underlying particle models is a major long-standing challenge. Here, we present a strategy to compute discretizations of $K$ from particle fluctuations via an infinite-dimensional fluctuation-dissipation relation, provided the particles are in local equilibrium with Gaussian fluctuations. A salient feature of the method is that $K$ can be fully pre-computed, enabling macroscopic simulations of arbitrary admissible initial data, without any need of further particle simulations. We test this coarse-graining procedure for a zero-range process in one space dimension and obtain an excellent agreement with the analytical solution for the macroscopic density evolution.
ELISA–based Point Prevalence of enteropathogens in diarrheic calves in Central Anatolia Region of Turkey

This study reports potential causes of diarrhea in neonatal calves, leading to calf mortality, from the selected population of the three Provinces of Turkey. A total of 300 fecal samples were collected purposively from diarrheic neonatal calves distributed to the three age groups (1–14 days, 15–29 days, and 30–90 days), from Konya, Karaman, and Aksaray Provinces of Turkey. The fecal specimens were examined for the existence of Cryptosporidium spp. , rotavirus, coronavirus, and Escherichia coli by commercially available capture direct enzyme linked immunosorbent assay (ELISA) kit. The oocysts and coproantigens of Cryptosporidium were identified in 109 (36.3%) and 156 (52%) of the 300 calves, respectively. While, rotavirus, E. coli and coronavirus antigens were detected (P<0.05) in 57 (19%), 17 (5.6%) and 6 (2%) calves, respectively. Mixed infection of the study pathogens has also been found in this report. These results provide a baseline information on the frequent causes of neonatal calf diarrhea in the studied Provinces which can be used to develop a prophylaxis plan.
Development and Evaluation of the Biological Adjuvant Bivalent Vaccine for Preventing Newcastle Disease and Infectious Bursal Disease

Newcastle disease (ND) and infectious bursal disease (IBD) are both one of the most economically important infectious diseases, which cause high infection rate and mortality of chickens and restrict the development of the poultry industry. Currently, vaccination is the most effective method to prevent ND and IBD. In this study, the biological adjuvant bivalent vaccine (rClone30-VP2L-chGM-CSF) was developed for preventing ND and IBD. Furthermore, the immune and protective effects of rClone30-VP2L-chGM-CSF were evaluated in specific-pathogen-free chickens. The experimental results indicated that chickens immunized with rClone30-VP2L-chGM-CSF vaccine significantly improved anti-IBDV and anti-NDV antibody titer; the level of CD4+ T, CD8+ T, B+, MHC-II+, and monocyte/macrophagocyte+ cells; the concentrations of IL-1β, IL-4, IL-17, IFN-α, IFN-β, and IFN-γ; and the splenocyte proliferation rate. Anti-NDV antibody titer reached the theoretical protection value of 4log2 at 7 days after immunization in chickens of rClone30-VP2L-chGM-CSF group; however, which at 14 days after immunization in chickens of rClone30-VP2L and rClone30. These results showed that chickens immunized with rClone30-VP2L-chGM-CSF stimulated stronger immune response than those with the rClone30-VP2L and rClone30. Chickens were challenged with virulent IBDV BC6/85, which were protected in the rClone30-VP2L-chGM-CSF group. Furthermore, IBDV RNA was not measured, and there appeared to be little apoptosis in the bursa of Fabricius in the rClone30-VP2L-chGM-CSF group. Therefore, rClone30-VP2L-chGM-CSF is a promising vaccine candidate against infectious bursal disease virus (IBDV) and newcastle disease virus (NDV), and it provides an idea for developing other poultry vaccines.
Evaluation of Nutrient Consumption for the Prevention of Chronic Diseases in Health Promotion Services: A Controlled and Randomized Community Trial to Promote Fruits and Vegetables

To evaluate the effectiveness of a collective intervention to encourage the consumption of fruits and vegetables on the nutrients intake for the prevention of chronic non-communicable diseases (NCDs), a randomized controlled community trial was conducted with a representative sample from the Health Academy Program. While the individuals in the control group (CG) participated in regular physical exercise, those in the intervention group (IG) also participated in a collective intervention. After 12 months, IG and CG showed a reduction in energy, omega 3 and sodium intake and an increase in the consumption of carbohydrates, fiber, vitamins, and minerals. Individuals from the CG showed an increase in phosphorus consumption and, in the IG, a reduction in the consumption of total, saturated, and polyunsaturated fats as well as an increase in the consumption of monounsaturated fats was seen. In both groups, there was an increase in the prevalence of adequate nutrients. Participation in the nutritional intervention was associated with lower consumption of energy and protein in the diet. The results pointed to the importance of individuals’ participation in the program, which, associated with nutritional intervention, promoted an improvement in the nutrient profile of the diet and the prevention and control of NCDs.
A Pectate Lyase Gene Plays a Critical Role in Xylem Vascular Development in Arabidopsis

As a major component of the plant primary cell wall, structure changes in pectin may affect the formation of the secondary cell wall and lead to serious consequences on plant growth and development. Pectin-modifying enzymes including pectate lyase-like proteins (PLLs) participate in the remodeling of pectin during organogenesis, especially during fruit ripening. In this study, we used Arabidopsis as a model system to identify critical PLL genes that are of particular importance for vascular development. Four PLL genes, named AtPLL15, AtPLL16, AtPLL19, and AtPLL26, were identified for xylem-specific expression. A knock-out T-DNA mutant of AtPLL16 displayed an increased amount of pectin, soluble sugar, and acid-soluble lignin (ASL). Interestingly, the atpll16 mutant exhibited an irregular xylem phenotype, accompanied by disordered xylem ray cells and an absence of interfascicular phloem fibers. The xylem fiber cell walls in the atpll16 mutant were thicker than those of the wild type. On the contrary, AtPLL16 overexpression resulted in expansion of the phloem and a dramatic change in the xylem-to-phloem ratios. Altogether, our data suggest that AtPLL16 as a pectate lyase plays an important role during vascular development in Arabidopsis.
Characterization and origin of dunitic rocks in the Ni-Cu-(PGE) sulfide ore-bearing Kevitsa intrusion, northern Finland: whole-rock and mineral chemical constraints

Th e ca. 2.06 Ga Kevitsa intrusion is one of the ore-bearing mafic-ultramafic igneous bodies in the Central Lapland greenstone belt. A large disseminated Ni-Cu-(PGE) sulfide ore deposit is hosted by olivine-pyroxene cumulates in the lower ultramafic part of the intrusion, indicating involvement of a multiply saturated magma in the ore formation. There are also various dunitic rocks, which occur as numerous inclusions within the Kevitsa intrusion, most commonly in the economic resource area. On textural basis, two distinct types of inclusions are recognized: i) cumulate-textured (Kevitsa Dunite) and ii) recrystallized ultramafic inclusions. In addition, there also exists a separate dunitic body (Central Dunite) with a suface area of 0.6 x 1.0 km, cropping out in the central part of the intrusion. The Central Dunite and Kevitsa Dunite are similar olivine-chromite cumulates and with comparable whole-rock and mineral compositions, suggesting that they are cogenetic. A magmatic, rather than replacement origin for the dunitic cumulates is evidenced by their systematic mineral compositional trends consistent with magmatic fractionation. Whole-rock major and trace element and mineral compositional data of the dunitic cumulates and Kevitsa olivine pyroxenites fall on the same linear trends and record similar REE characteristics indicating a genetic link between these two. The parental magmas for the dunitic cumulates were probably picritic and related to the picritic and basaltic volcanic rocks in the area. The high Fo content of olivine (up to ~89 mol.%) is consistent with a high-Mg parental melt. The recrystallized ultramafic inclusions are fine-grained and show a granoblastic/inter-lobate textures indicative for thermal textural readjustment. Two subgroups are identified: Group 1 shows a chemical affinity towards the dunitic cumulates and are interpreted as their recrystallized clasts. The Group 2 inclusions are compositionally comparable to the ~2.06 Ga komatiitic volcanic rocks in the area and are considered as dehydrated metavolcanic xenoliths. A decrease in the flow rate of the Kevitsa magmas due to entrapment of a high number of inclusions is proposed as a mechanism to promote settling of sulfides, contributing to the formation of the Ni-Cu-(PGE) ore.
When do generics lead to social essentialism: developmental evidence from Iran

Generic descriptions (e.g., “girls are emotional”) are argued to play a major role in the development of essentialist reasoning about social categories (Rhodes et al., 2018). However, studies have been conducted dominantly in English-speaking communities and among Western samples. This is a significant limitation given that a number of theories focus on the linguistic form of generic statements and distinguish between form and content in leading to essentialism. In this study, we plan to extend the research on generics and social essentialism beyond English-speaking, Western samples. We aim to explore how generic statements with different content (biological or cultural) about a novel social category may lead to essentialist beliefs among children and adults in Iran, a Persian-speaking community that is underrepresented in the literature. Using a design similar to Noyes & Keil (2020), we plan to expose 4 to 9-year-old children (N = 104) and adults (N = 104) to generic or specific statements (between subjects) ascribing biological or cultural features to a novel social category. We will measure the degree to which exposure to these statements leads to essentialist reasoning in terms of inheritability and “kindhood”. This work contributes to diversifying the field and informs theories of social essentialism. When do generics lead to social essentialism: developmental evidence from Iran
The Role of Activation of PI3K/AKT/mTOR and RAF/MEK/ERK Pathways in Aggressive Pituitary Adenomas—New Potential Therapeutic Approach—A Systematic Review

Pituitary tumors (PT) are mostly benign, although occasionally they demonstrate aggressive behavior, invasion of surrounding tissues, rapid growth, resistance to conventional treatments, and multiple recurrences. The pathogenesis of PT is still not fully understood, and the factors responsible for its invasiveness, aggressiveness, and potential for metastasis are unknown. RAF/MEK/ERK and mTOR signaling are significant pathways in the regulation of cell growth, proliferation, and survival, its importance in tumorigenesis has been highlighted. The aim of our review is to determine the role of the activation of PI3K/AKT/mTOR and RAF/MEK/ERK pathways in the pathogenesis of pituitary tumors. Additionally, we evaluate their potential in a new therapeutic approach to provide alternative therapies and improved outcomes for patients with aggressive pituitary tumors that do not respond to standard treatment. We perform a systematic literature search using the PubMed, Embase, and Scopus databases (search date was 2012–2023). Out of the 529 screened studies, 13 met the inclusion criteria, 7 related to the PI3K/AKT/mTOR pathway, and 7 to the RAF/MEK/ERK pathway (one study was used in both analyses). Understanding the specific factors involved in PT tumorigenesis provides opportunities for targeted therapies. We also review the possible new targeted therapies and the use of mTOR inhibitors and TKI in PT management. Although the RAF/MEK/ERK and PI3K/AKT/mTOR pathways play a pivotal role in the complex signaling network along with many interactions, further research is urgently needed to clarify the exact functions and the underlying mechanisms of these signaling pathways in the pathogenesis of pituitary adenomas and their role in its invasiveness and aggressive clinical outcome.
Nutritional compositions of Katuk leaves and their supplementation to hays of different quality: an in vitro study

Katuk leaves (Sauropus androgynus (L.) Merr. ; KL) are widely consumed by breast-feeding Indonesian mothers as it has been reported to increase breast milk production. It is hypothesized that supplementing KL in diets might increase crude protein (CP) concentration and fibre digestibility in the diet. The KL had high CP and non-fibre carbohydrate concentrations (333 and 332 g/kg dry matter; DM, respectively), but low neutral detergent fibre assayed with heat, a stable amylase and expressed exclusive of residual ash (aNDFom; 200 g/kg DM). Fibre digestibility linearly increased with increasing of KL supplementation in low-quality hay (LQH) diets. The KL did not contain a considerable amount of tannins. In LQH diets, gas production after 24 h incubation (GP24) linearly increased with increasing of KL supplementation (P < 0.001). Meanwhile, GP24 linearly decreased with increasing of KL supplementation in medium- and high-quality hays (MQH and HQH; P < 0.001). Metabolizable energy tended to linearly increase in LQH diets, but tended to linearly decrease with increasing of KL supplementation in MQH and HQH diets (P = 0.078). Therefore, this study suggested that KL can be a potential supplement in the ruminant diet due to its abundant dietary proteins but low fibre concentration in its leaves. However, further studies (e.g. in vitro or in vivo) investigating other rumen parameters after incubation should be performed to validate how KL can be supplemented in the diet of ruminant livestock.