Miracle-dz/UniFAR-FTUs huggingface dataset:
Toma de decisiones emotivas: un análisis desde la teoría de las perspectivas

El objetivo del presente estudio fue comprobar si los efectos de certeza y reflexion propuestos por la teoria prospectiva se mantienen al anadir una carga afectiva a los estimulos en situaciones de riesgo. Las hipotesis planteadas fueron que, tanto en situaciones de ganancia como en situaciones de perdida, las personas tenderian a elegir la alternativa rica en afecto, independientemente de que se trate de una opcion segura o probable. La muestra estuvo compuesta por 320 alumnos del grado de Psicologia, predominantemente mujeres, los cuales se dividian en grupos de 40 personas para cada condicion experimental. A todos ellos se les presento un problema para que eligieran entre dos opciones de respuesta. Los metodos estadisticos empleados fueron la Prueba Z para muestras independientes y la prueba binomial. Los resultados obtenidos mostraron que no existen diferencias estadisticamente significativas al comparar las condiciones de ganancia entre si, ni tampoco entre las condiciones de perdida, de modo que se vieron confirmadas las hipotesis planteadas ya que la mayoria de los participantes se decantaba por la opcion con carga afectiva en todas las condiciones, desapareciendo los efectos de certeza y reflexion propuestos por la teoria prospectiva.
Regulation of the DNA damage response by R2TP mediated MRN complex assembly and control of 53BP1 localisation.

DNA double strand breaks are the most dangerous type of DNA damage. The MRN complex and 53BP1 have essential functions in the repair of DNA double strand breaks and are therefore important for maintaining genomic stability and preventing cancer. DNA double strand breaks are repaired by two main mechanisms homologous recombination and non-homologous end joining. The MRN complex senses DNA double strand breaks and activates a cascade of posttranslational modifications that activates and recruits other effector proteins. In addition MRN mediated resection is important for removing adducts in non-homologous end joining and creating single stranded DNA required for homologous recombination. 53BP1 is recruited to DNA double strand breaks by site specific ubiquitinations and inhibits DNA resection, thereby promoting nonhomologous end joining at the expense of homologous recombination. In this thesis we show that MRE11 binds to the R2TP chaperone complex through a CK2 mediated phosphorylation. Knockdown of R2TP or mutating the MRE11 binding site leads to decreased MRE11 levels and impaired DNA repair. Similar phenotype has been observed in cells from patients with ataxiatelangiectasia-like disorder (ATLD), containing MRE11 deletion mutation which is missing the R2TP complex binding site. Based on R2TP complex function as a molecular chaperone, we conclude, that R2TP complex is important for MRN complex assembly/quality control. Moreover, we explored the processes important for regulating localisation of DNA repair protein 53BP1 to the nucleus and DNA damage site. We investigated PLK1 and CDK1 mediated phosphorylations in 53BP1 ubiquitin binding domain and discovered that they inhibit 53BP1 recruitment to the DNA damage site in mitosis. Finally we discovered the sequence of 53BP1 localisation signal and explored regulatory mechanisms of 53BP1 nuclear localisation by post translational modifications. In conclusion, we deepened our understanding of MRN complex assembly and pathophysiology of a specific MRE11 mutation leading to ATLD. In addition we found new ways of regulation of 53BP1 localization and function.
Developing Cyber-bullying Knowledge and Awareness Instrument (CBKAi) to Measure Knowledge and Perceived Awareness Towards Cyber-bullying among Adolescents

In this study, the researcher developed an instrument to measure the level of adolescents’knowledge and perceived awareness on cyber - bul l ying. This instrument is known as the Cyber - bullying Knowledge and Awareness Instrument (CBKA i ). Content validity was performed to determine whether the instrument comprises a representative sample of the behaviour domain to be measured. CBKAi was validated by a senior lecturer from a public university who is also an expert in cyber - bullying and also two secondary school counsellors.Apart from that, CBKAi was also tested for its reliability with 30 r espondents. The Cronbach’s alpha internal consistency reliability coefficient for the instrument is 0.919 for items that are related to knowledge and 0.810 for items that are related for perceived awareness. The statistics show that CBKAi is a reliable ins trument to be utilized to measure knowledge and perceived awareness towards cyber - bullying among adolescents.
Fuel Cell Performance Implications of Membrane Electrode Assembly Fabrication with Platinum-Nickel Nanowire Catalysts

Platinum-nickel nanowire (PtNiNW) catalysts have shown exceptionally high oxygen reduction mass activity in rotating disk electrode measurements. However, the ability to successfully incorporate PtNiNWs into high performance membrane electrode assemblies (MEAs) has been challenging due to their size, shape, density, dispersion characteristics, and corrosion-susceptible nickel core. We have investigated the impact of specific processing steps and electrode composition on observed fuel cell performance and electrochemical properties in order to optimize performance. We have found that nickel ion contamination is a major concern for PtNiNWs that can be addressed through ion exchange in fabricated/tested MEAs or by acid leaching of catalyst materials prior to MEA incorporation, with the latter being the more successful method. Additionally, decreased ionomer incorporation has led to the highest performance demonstrating 238 mA/mgPt (0.9 V IR-free) for PtNiNWs (pre-leached to 80 wt% Pt) with 9 wt% ionomer incorporation. © The Author(s) 2018. Published by ECS. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License (CC BY, http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse of the work in any medium, provided the original work is properly cited. [DOI: 10.1149/2.1061803jes]
Silver Nanoparticles Biotransforming Bacteria Isolated from Silver-Craft Waste

The use of silver resistant bacteria in the synthesis of nanoparticles emerges as an eco-friendly approach. In the current study, biotransformation of silver ion becomes silver nanoparticles by silver resistant bacteria BAgBK3 was reported. These transformed silver nanoparticles were observed using UV-Visible spectrophotometery and TEM. The absorption of silver colloids has detected a broad peak at 410 nm corresponding to the plasma resonance of silver nanoparticles. The synthesized nanoparticles were found to be spherical shape with a size in the range of 9 – 13 nm. It was scattered around the edge and around of bacteria cell. Nitrate reductase enzyme involved in the biotransformation of silver ion to silver nanoparticles. Isolate strain BAgBK-3 is a promising bacteria for AgNPs biotransformation.
New compounds for treating amyloid or amyloid-like protein associated diseases

FIELD: medicine, pharmaceutics. SUBSTANCE: present invention refers to new compounds of formula II which have the values of radicals and symbols specified in the patent claim. The present invention also refers to a pharmaceutical composition containing said compounds, as well as application of said compounds for preparing drug preparations for treating and preventing amyloid and/or amyloid-like protein associated diseases or conditions. EFFECT: compounds may be used in treating a group of amyloid protein associated disorders and abnormalities, such as Alzheimer's disease, and amyloid protein associated diseases or conditions; the compounds of the present invention may be used for treating ocular diseases related to pathological disturbances and changes in visual system tissues. 19 cl, 5 tbl, 32 ex
Etude de la matière interstellaire : Caractérisation de l'émission des grains

Mon travail de these est centre sur la comprehension des proprietes d'emission des gros grains de poussieres dans le domaine submillimetrique et du couplage de ces grains avec le gaz interstellaire dans les regions froides et denses. Des observations astrophysiques marquantes (PRONAOS, FIRAS) revelent que les grains possedent a grande longueur d'onde des proprietes d'emission inattendues qui ne peuvent pas etre comprises par la seule consideration des modeles usuels. Pour expliquer ces proprietes, nous avons propose un modele original d'emission des grains, base sur les proprietes physiques intrinseques des solides amorphes. Ce modele permet de rendre compte de l'anticorrelation existant entre la temperature d'equilibre des gros grains T et leur indice spectral d'emissivite Β, deduite des mesures PRONAOS (Dupac et al. 2003) mais egalement de l'exces submillimetrique observe par FIRAS. Il permet ainsi d'interpreter deux faits observationnels distincts qui n'avaient jamais ete expliques de maniere simultanee et definit ainsi le canevas d'un futur modele de grains. Pour avoir une meilleure comprehension des proprietes d'emission/absorption des grains, j'ai complete ce travail theorique par des experiences en laboratoire sur les proprietes d'absorption de differents types de silicates amorphes, a basse temperature et grande longueur d'onde. Pour la premiere fois, nous avons analyse nos spectres d'absorption en distinguant deux domaines frequentiels (500Μm-1mm et 100Μm-200Μm) dans lesquels l'absorption presente une dependance frequentielle differente. Pour des longueurs d'onde comprises entre 500Μm et 1mm, l'indice spectral Β presente une anti-correlation marquee avec la temperature, d'allure similaire a celle mesuree par le ballon PRONAOS. Cette variation de l'absorption pourrait etre expliquee par la presence de defauts (groupements OH ou ions modifiant le reseau). Dans les environnements froids et denses, les proprietes d'emission des grains sont modifiees notamment par les processus d'agglomeration des grains entre eux, processus favorises par la presence de manteaux de glace. Dans ce cadre il apparaissait interessant de relier les modifications des proprietes d'emission des grains a celles du gaz. Le traitement et l'analyse de donnees moleculaires CO et N2H+ en direction d'un filament de la constellation du Taureau nous a permis de demontrer que le processus d'agglomeration des grains entre eux n'etait pas initie par la presence de manteaux de glace de CO mais plus probablement par celle de manteaux de glace de H2O. Enfin, nous avons confirme les resultats de SWAS sur la sous-abondance de l'eau en phase gazeuse dans les environnements froids et denses en etudiant, en direction d'un nuage sombre (Cha-MMS1), la raie d'emission submillimetrique de l'eau dans sa transition fondamentale avec le satellite ODIN.
Synergistic Effect of Graphene Oxide for Impeding the Dendritic Plating of Li

Dendritic growth of lithium (Li) has severely impeded the practical application of Li‐metal batteries. Herein, a 3D conformal graphene oxide nanosheet (GOn) coating, confined into the woven structure of a glass fiber separator, is reported, which permits facile transport of Li‐ions thought its structure, meanwhile regulating the Li deposition. Electrochemical measurements illustrate a remarkably enhanced cycle life and stability of the Li‐metal anode, which is explained by various microscopy and modeling results. Utilizing scanning electron microscopy, focused ion beam, and optical imaging, the formation of an uniform Li film on the electrode surface in the case of GO‐modified samples is revealed. Ab initio molecular dynamics (AIMD) simulations suggest that Li‐ions initially get adsorbed to the lithiophilic GOn and then diffuse through defect sites. This delayed Li transfer eliminates the “tip effect” leading to a more homogeneous Li nucleation. Meanwhile, CC bonds rupture observed in the GO during AIMD simulations creates more pathways for faster Li‐ions transport. In addition, phase‐field modeling demonstrates that mechanically rigid GOn coating with proper defect size (smaller than 25 nm) can physically block the anisotropic growth of Li. This new understanding is a significant step toward the employment of 2D materials for regulating the Li deposition.
Novel Approach and Correlation for Bubble Size Distribution in a Slurry Bubble Column Reactor Operating in the Churn–Turbulent Flow Regime

A novel approach to obtain bubble size distributions and Sauter mean bubble diameters (d32) in three-phase slurry bubble column reactors (SBCRs) is presented. This approach is based on 720 experimental runs using the dynamic gas disengagement (DGD) technique for various gas–liquid–solid systems inside a pilot-scale-SBCR (0.3 m i.d./3 m height), in a wide range of pressures (1–30 bar), temperatures (298–530 K) and solid concentrations (0–17 vol %). The bubble size distributions were obtained using an iterative energy balance algorithm based on transient experimental pressure drops and forces exerted on bubbles in the disengagement cell. Bubble size distributions were described using log-normal distribution functions and the mean and variance were determined for the DGD runs. The mean and variance were correlated as functions of the system’s physical properties and operating conditions, and were used to predict d32 values with an absolute average relative error (AARE) of 11.72%. The approach was also applie.
Essential oils and biological activities of three selected wild Alpinia species

Essential oils of three selected wild Alpinia species, namely Alpinia murdochii Ridl. , Alpinia pahangensis Ridl. and Alpinia scabra (Blume) NAives, were obtained by hydrodistillation. The chemical components and their composition in the essential oils of the rhizomes and the leaves were investigated using gas chromatography (GC), gas chromatography-mass spectrometry (GC-MS) and Kovats indices analysis. Some of the components commonly observed in the essential oils of these wild Alpinia species were I²- pinene, I±-pinene, limonene, I³-selinene, I±-terpineol, terpinene-4-ol and sabinene. The chemical components of two closely related species, A. murdochii and A. pahangensis were compared in terms of similarities of compounds. 36.6 % of compounds were similar in their leaf oils and 45 % of compounds were similar in their rhizome oils. The marker compound of Alpinia species, 1, 8-cineole was only present in A. pahangensis rhizome oils and A. scabra leaf oils with low concentrations (0.63 % and 0.08 % respectively). The essential oils obtained were tested for their biological activities namely antimicrobial activity, antioxidant activity and anti-inflammatory activity. For the antimicrobial activity, the minimum inhibitory concentration (MIC) assay was applied. The rhizome oils of these three Alpinia species exhibited potent inhibition against VISA and their MIC values were lower than oxacillin. Meanwhile, A. pahangensis rhizome oils also showed potent activity against Sa 7 (Staphylococcus aureus strain) with a lower MIC value compared to oxacillin.The antioxidant activity was tested using two assays, DPPH free radical scavenging assay and reducing power assay. In DPPH free radical scavenging assay, A. scabra rhizome oil exhibited the highest percentage of inhibition with 55.17 % Â± 1.23 at a concentration of 5 mg/ml. At the same concentration, A. scabra rhizome oil also showed the highest reducing power of 1.085 Â± 0.004. The assays used for the anti-inflammatory activity were hyaluronidase assay and lipoxygenase assay. In the hyaluronidase assay, at the concentration of 100 I¼g / I¼L, all the oils tested showed moderate activity (40.63 Â± 4.31 % until 66.38 Â± 9.43 %) except for A. pahangensis leaf oils (38.41 Â± 6.34 %). Leaf and rhizome oils of A. murdochii and rhizome oil of A. scabra exhibited high inhibition percentages on lipoxygenase assay with 95.37 Â± 6.55 %, 91.11 Â± 7.82 % and 90.42 Â± 0.10 % respectively.
Le potassium, remède contre la sécheresse ?

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Le potassium, remède contre la sécheresse ? Elsa Martineau, Lionel Jordan-Meille, Christophe Nguyen
Rutin and Proanthocyanidin Contents in Buckwheat Grains: Combined Biosynthesis in Interspecific Hybrids between Fagopyrum esculentum Moench x F. homotropicum Ohnishi and their Progeny

Nutrient content of soil was measured using a traditional method (Hungarian Standard Msz-08 0206) and after 0.01 M CaCl2 extraction. Better knowledge of 0.01 M CaCl2 extractable nutrients may help to improve the efficient use of fertilizers and organic manure. The amount of nitrate nitrogen (NO3--N), ammonium nitrogen (NH4+-N) and organic nitrogen (organic-N) were measured in plots of buckwheat seed production in Ny{i}regyhaza. The aim of this paper was to present data on the nitrogen supplying capacity of sandy, brown forest soil. We also studied 0.01 M CaCl2 extractable phosphorus, potassium, magnesium nutrients and soil pH. The main objective was to determine the effects of the nutrient supplying capacity of soil on buckwheat yields in organic agriculture. In organic agriculture, nutrient management is based on the self-sufficiency of the farm, on the entire organic matter production cycle and on the decomposition which takes place within the farm making the farm a sustainable biological system. The rate of metabolism and the organic matter cycle are characteristic features of such production. In our experiment, nitrate-nitrogen (NO3-N) was highly correlated with the buckwheat yield and the utilised 0.01 M CaCl2 extraction method offers useful information for developing environmentally sound, sustainable agriculture.
Electrolyte and Temperature Effects on Third-Order Susceptibility in Sum-Frequency Generation Spectroscopy of Aqueous Salt Solutions

Sum-frequency generation (SFG) spectra from charged solid–liquid interfaces include significant contribution from third-order susceptibility χ(3), which mainly originates from induced water orientation in the electric double layer. We quantitatively evaluate the χ(3) susceptibility by molecular dynamics simulation in aqueous electrolyte solutions with varying concentrations and temperatures. We found that the value of χ(3) decreases with increasing concentration or temperature and that the perturbation on χ(3) is quite well-correlated with that on the dielectric constant ϵ of the solution. This correlation is understood as both quantities are commonly governed by the response of molecular orientation to the electric field. Accurate evaluation of χ(3) in various conditions is important in quantitative estimate of the third-order effect on the SFG spectroscopy, particularly in conditions of high surface charge and ion concentration.
Hydrophilic and strengthened 3D reduced graphene oxide/nano-Fe3O4 hybrid hydrogel for enhanced adsorption and catalytic oxidation of typical pharmaceuticals

A simple method for the preparation of a three-dimensional (3D) reduced graphene oxide/Fe3O4 (3D-rGO/Fe3O4) hybrid hydrogel was developed via the reduction of graphene oxide by ferrous ions and in situ simultaneous generation of tunable Fe3O4 nanoparticles on graphene sheets. After drying at 50 °C for 1 h, its mechanical strength was enhanced according to elastic modulus analysis. The hydrophilic and strength-enhanced hybrid was suitable for the removal of two typical pharmaceuticals including ciprofloxacin (CIP) and tetracycline (TC). Their adsorption kinetics, isotherms, pH and cation effects on 3D-rGO/Fe3O4 were studied. The adsorption capacities of 3D-rGO/Fe3O4 were 2.78 mmol g−1 for CIP and 4.76 mmol g−1 for TC according to the Langmuir fitting results, which are much higher than those of commercial granular activated carbons and other graphene-based hydrogels. Moreover, the spent 3D-rGO/Fe3O4 can be easily regenerated by Fenton-like catalytic oxidation with little loss of adsorption capacity after ten adsorption–oxidation cycles. The textural structure and surface functional groups on the adsorbent were hardly changed during the oxidative regeneration process. Benefiting from its superiority, both enhanced adsorption and catalytic degradation of pharmaceuticals were simultaneously achieved using this novel hybrid hydrogel, making it competitive in the removal of micropollutants from water or wastewater.
Characterization of novel post-translational modifications of microtubule associated proteins and immunologically related modifications of dna topoisomerase II /

As a component of the cytoskeleton, microtubules (MTs) play indispensable roles during the cell cycle and neuronal development. MT dynamics and functions are regulated by a group of proteins called microtubule associated proteins (MAPs), which in turn are regulated by post-translational modifications. It has been established that MAPs are phosphorylated in a cell cycle dependent and/or developmentally regulated fashion. One phosphorylation site, recognized by the monoclonal antibody MPM-2, is found on both MAP4 in mitotic cells and MAP1B in differentiating PC12 cells. MPM-2 antibody also recognizes mitotic DNA topoisomerase II, an enzyme required during mitosis. This study documents work on post-translational modification of MAPs as well as the phosphorylation site shared by MAPs and topoisomerase II. It is shown here that M A P I, MAP2, and MAP4 are glycosylated. In particular, MAP2 and MAP4 are modified by a single Olinked N-Acetylglucosamine (O-GlcNAc), adding MAPs to the family of intracellular O-GlcNAc modified proteins. At least 10% of brain MAP2 is modified by O-GlcNAc. Multiple O-GlcNAc modification sites exist on MAP2, and these are all located in the MAP2 projection domain. The phosphorylation of MAPs was examined using a series of synthetic phosphopeptides based upon the MPM-2 phosphoepitope shared between certain MAPs and topoisomerase II. The most essential element ii of the MPM-2 epitope identified here consists of an aromatic amino acid -2 residues N-terminal to the phosphorylated threonine. An aromatic amino acid at the +2 position is also important for the antibody recognition. This sequence is indeed the in vivo MPM-2 epitope as substantiated by a rabbit polyclonal antibody generated against the topoisomerase II synthetic phosphopeptide. This affinity purified antibody, PTE1, recognized a band that co-migrates with DNA topoisomerase II on immunoblots of mitotic cells. Preincubation with the phosphopeptide, but not the dephosphopeptide, abolished PTETs ability to recognize this band. PTE1 also recognizes a distinctive group of proteins in mitotic HeLa cell lysates. Immunocytochemical localization has shown that PTE1 specifically stains mitotic chromosomes, spindle poles and midbodies. These results indicate that proteins recognized by the PTE1 antibody share phosphoepitopes recognized by the MPM-2 antibody, including those present on several MAPs.