Miracle-dz/UniFAR-FTUs huggingface dataset:
Milnacipran and venlafaxine at flexible doses (up to 200 mg/day) in the outpatient treatment of adults with moderate-to-severe major depressive disorder: a 24-week randomized, double-blind exploratory study

: The objective of this exploratory, multicenter, randomized, double-blind study, was to evaluate the efficacy and safety/tolerability of milnacipran and venlafaxine administered at flexible doses (100, 150 or 200 mg/day, bid administration) for 24 weeks (including 4 weeks up titration period) in the outpatient treatment of adults presenting with a moderate or severe episode of major depressive disorder (MDD) without high suicidal risk (MINI-DSM IV-TR). Of the 195 patients included, 134 (68.7%) completed the study. At baseline the two groups were similar, except there was a higher proportion of patients whose episode was severe-DSM IV in the milnacipran group (63.3% versus 54.0% in the venlafaxine group). The initial MADRS score (mean 31.0) decreased progressively during the study, and this decrease was in the two treatment groups (n = 177: 90 milnacipran; 87 venlafaxine) at week 24 (observed case/OC, mean change –23.1 milnacipran; –22.4 venlafaxine). The rate of MADRS response (reduction  50%) at week 8 and week 24-last observation carried forward/LOCF was similar in the two groups (week 8: 64.4% milnacipran; 65.5% venlafaxine; week 24: 70% milnacipran; 77% venlafaxine), as was the rate of MADRS remission (score  10) (week 8: 42.2% milnacipran; 42.5% venlafaxine; week 24: 52.2% milnacipran; 62.1% venlafaxine). In both groups, the most common adverse events were: nausea, dizziness, headache, hyperhidrosis and, in males, genito-urinary problems. The overall safety/tolerability and efficacy profiles of milnacipran and venlafaxine administered at flexible dosages (up to 200 mg/day) were similar in the long term treatment of adults during episodes of MDD in an
Low-coverage sequencing : Implications for design of complex trait Material Supplemental

object identifier (DOIs) and date of initial publication. by PubMed from initial publication. Citations to Advance online articles must include the digital publication). Advance online articles are citable and establish publication priority; they are indexed appeared in the paper journal (edited, typeset versions may be posted when available prior to final Advance online articles have been peer reviewed and accepted for publication but have not yet
Effect of turbulence on the wake of a wall-mounted cube

The influence of turbulence on the flow around a wall-mounted cube immersed in a turbulent boundary layer is investigated experimentally with particle image velocimetry and hot-wire anemometry. Free-stream turbulence is used to generate turbulent boundary layer profiles where the normalised shear at the cube height is fixed, but the turbulence intensity at the cube height is adjustable. The free-stream turbulence is generated with an active grid and the turbulent boundary layer is formed on an artificial floor in a wind tunnel. The boundary layer development Reynolds number ( $Re_{x}$ ) and the ratio of the cube height ( $h$ ) to the boundary layer thickness ( $\unicode[STIX]{x1D6FF}$ ) are held constant at $Re_{x}=1.8\times 10^{6}$ and $h/\unicode[STIX]{x1D6FF}=0.47$ . It is demonstrated that the stagnation point on the upstream side of the cube and the reattachment length in the wake of the cube are independent of the incoming profile for the conditions investigated here. In contrast, the wake length monotonically decreases for increasing turbulence intensity but fixed normalised shear – both quantities measured at the cube height. The wake shortening is a result of heightened turbulence levels promoting wake recovery from high local velocities and the reduction in strength of a dominant shedding frequency.
Feedback Linearization Control for Systems with Mismatched Uncertainties via Disturbance Observers

This paper focuses on a novel feedback linearization control (FLC) law based on a self‐learning disturbance observer (SLDO) to counteract mismatched uncertainties. The FLC based on BNDO (FLC‐BNDO) demonstrates robust control performance only against mismatched time‐invariant uncertainties while the FLC based on SLDO (FLC‐SLDO) demonstrates robust control performance against mismatched time‐invariant and ‐varying uncertainties, and both of them maintain the nominal control performance in the absence of mismatched uncertainties. In the estimation scheme for the SLDO, the BNDO is used to provide a conventional estimation law, which is used as the learning error for the type‐2 neuro‐fuzzy system (T2NFS), and T2NFS learns mismatched uncertainties. Thus, the T2NFS takes the overall control of the estimation signal entirely in a very short time and gives unbiased estimation results for the disturbance. A novel learning algorithm established on sliding mode control theory is derived for an interval type‐2 fuzzy logic system. The stability of the overall system is proven for a second‐order nonlinear system with mismatched uncertainties. The simulation results show that the FLC‐SLDO demonstrates better control performance than the traditional FLC, FLC with an integral action (FLC‐I), and FLC‐BNDO.
Input Impedance of an Aperture Over a Lossy Half-Space: Application to on-Body Antenna Performance at 60 GHz

This paper presents a theoretical approach to compare the performance of a directive and a quasi-omnidirectional on-body antennas. Two canonical antennas, namely, a dipole and a rectangular aperture, are considered in the 60 GHz band. We first demonstrate that for this on-body configuration, the classically-defined far-field antenna gain depends on the observation distance. Consequently, we derive results in terms of radiation efficiency and link budget. To do so, the antenna input impedance computation is a preliminary step to normalize the input power to allow a fair comparison between the two antennas. The impedance over a lossy half-plane of an aperture illuminated by a TE 10 mode normally polarized is therefore derived into a convenient easy-to-compute formulation, which to authors' best knowledge, is not available in the literature. In terms of link budget, it is obtained that the received power due to an aperture is generally higher than the one due to the dipole in the main lobe direction. A constant difference is observed along the distance and this difference increases with the aperture width for antennas touching the body. Besides, it is shown that the standard aperture waveguide WR15 exhibits a slightly higher efficiency than a vertical dipole with the same vertical size when placed at a distance less than 3 mm (i.e., 0.6 λ) from the body phantom surface. Above this distance, both the dipole and the aperture exhibit similar efficiency in the order of 60 %.
CHEMOTAXIS DIFFERENTIAL EVOLUTION OPTIMIZATION TECHNIQUES FOR GLOBAL OPTIMIZATION

CHEMOTAXIS DIFFERENTIAL EVOLUTION OPTIMIZATION TECHNIQUES FOR GLOBAL OPTIMIZATION Yildiz, Yunus Emre Ph.D., Department of Computer Engineering Supervisor: Dr. Oguz Altun June 2016 Nature inspired and bio-inspired algorithms have been recently used for solving low and high dimensional search and optimization problems. In this context, Bacterial Foraging Optimization Algorithm (BFOA) and Differential Evolution (DE) have been widely employed as global optimization techniques inspired from social foraging behavior of Escheria coli bacteria and evolutionary ideas such as mutation, crossover, and selection, respectively. BFOA employs chemotaxis (tumble and run steps of a bacterium in its lifetime) activity for local search whereas the global search is performed by elimination-dispersal operator. Elimination-dispersal operator kills or disperses some bacteria and replaces others randomly in the search space. This operator mimics bacterium’s death or dispersal in case of high temperature or sudden water flow in the environment.
Generalization Error and Out-of-bag Bounds in Random (Uniform) Forests

In the context of ensemble learning, especially for random forests models, the out-of-bag (OOB) procedure, using the training set, produces an estimation of the generalization error. The OOB error has the same purpose than the cross-validation error, but comes with very specific points. First, there exists an OOB classifier that leads to the OOB evaluation. Second, the OOB classifier is embedded in the forest classifier. We show in this paper that these two intrinsic properties lead to produce simple conditions for the test error to be bounded by the OOB error. Conditions come with the only required and usual assumptions which are the i.i. d one and the existence of first and second order moments. The main interest is that the OOB error is explicitly known, hence one just needs a training set without any other assumption on the model behind the data. As a practical case, we use Random Uniform Forests (Ciss, 2015a), a variant of Random Forests (Breiman, 2001) that inherits of all properties of the latter, to show how OOB bounds apply. We also provide an R package, randomUniformForest, allowing to experiment all the arguments described in the paper.
Generative model of art

Orientador: Prof. Mestre Robert Wiley, Professor Convidado, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa Co-orientador: Prof. Elena Tereshina, Doutora em Ciências Biológicas, Head. lipídico laboratório russo Gerontological Centro de Pesquisa e Clínica do National Research University Medical russo. NV Pirogov Examinadores: Doutora Márcia Gomes Vilarigues, Professora Assistente e Coordenadora VICARTE, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa; Doutor Pedro Jorge Caldeira de Matos Fortuna, Professor Assistente, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa Presidente: Doutora Rita Andreia Silva Pinto de Macedo, Professora Assistente, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa
A scenario simulation approach for sustainable mobility project evaluation based on fuzzy cognitive maps

Abstract Sustainability evaluation of new urban mobility projects is a challenging decision due to the presence of multiple objectives (social, economic, environmental), limited data availability, presence of multiple stakeholders, and specific context of each city. Scenario modeling and simulation is a useful tool to address such situations. In this paper, we present a fuzzy cognitive mapping-based scenario simulation approach for evaluating sustainable mobility projects. Linguistic assessments and fuzzy set theory are used to address the uncertainty arising from lack of quantitative data. The criteria for sustainability evaluation are obtained using fuzzy Delphi technique. A numerical application is provided for the city of Luxemburg. The strength of the proposed approach is the ability to aid in decision-making of new sustainable mobility project evaluation and selection under limited or no quantitative data availability. In addition, it is able to deal with multiple, co-related and conflicting criteria in evaluation.
HESPERETIN ATTENUATES TEICOPLANIN-INDUCED ACUTE KIDNEY INJURY BY MITIGATING OXIDATIVE STRESS AND INFLAMMATION IN WISTAR RAT

Objectives: Renal failure has been reported in patients treated with Teicoplanin, a widely used antibiotic. Hesperetin, a flavonoid in citrus fruits, has been reported to possess nephro-protective effects. This study investigated the protective effect of hesperetin on teicoplanin-induced nephrotoxicity in rats. Methods: Male wistar rats (n=32, 144-180 g) were grouped into 4 groups of 8 rats each. The control, group 1 received water, group 2 received 50 mg/kg of hesperetin orally, group 3 received 10 mg/kg of teicoplanin intraperitoneally and group 4 received 50 mg/kg of hesperetin and 10 mg/kg of teicoplanin. Administration was done for 21 days. Rats were sacrificed 24 hours after the last administration, the kidney was excised and used for biochemical assays. Results: Administration of teicoplanin resulted in kidney injury that was characterized by significant increase in plasma urea and creatinine level relative to control group (p<0.05). Additionally, significant increase in biomarkers of inflammation (NO, MPO, TNF-α) and lipid peroxidation (malondialdehyde) of teicoplanin-treated rats were observed when compared with the control group. Furthermore, altered antioxidants status was observed following teicoplanin treatment. Activities of enzymic antioxidants (SOD, CAT, GPx, GST) and concentration of non-enzymic antioxidants (GSH and Ascorbic acid) were downregulated. In comparison to the teicoplanin-treated group, the administration of Hesperetin with teicoplanin significantly reduced all changes in the markers of kidney injury, inflammation, and oxidative stress. Histopathological examination revealed that rats given TEIC showed increased glomerular size and considerable hydropic changes in the proximal convoluted tubules, whereas rats given HESP and TEIC showed only mildly enhanced glomerular size and hydropic modifications. Conclusion: Hesperetin preserved the histo-architecture of the kidney. From this study, hesperetin offered a protective effect against teicoplanin-induced nephrotoxicity in rats.
Mathematical analysis of a model for the transmission dynamics of Trichomonas vaginalis (TV) and HIV coinfection

A deterministic model for the transmission dynamics of HIV and Trichomonas vaginalis (TV) in a human population is designed and rigorously analysed. The model is shown to exhibit the phenomenon of backward bifurcation, where a stable disease‐free equilibrium coexists with a stable endemic equilibrium whenever the associated reproduction number is less than unity. This phenomenon can be removed by assuming that the coinfection of individuals with HIV and TV is negligible. Furthermore, in the absence of coinfection, the disease‐free equilibrium of the model is shown to be globally asymptotically stable whenever the associated reproduction number is less than unity. Numerical simulation of the model, using initial and demographic data, shows that increased incidence of TV in a population increases HIV incidence in the population. It is further shown that control strategies, such as the treatment, condom use, and counselling of individuals with TV symptoms, can lead to the effective control or elimination of the HIV in the population if their effectiveness level is high enough. The time to disease elimination is reduced if more than one strategy (hybrid strategy) is considered.
Readout QDC for CdTe x-ray imager using direct charge treatment

X-ray imaging is popular in medical imaging, non-destructive testing and security. Main techniques of X-ray imaging with semiconductor detectors are charge accumulation and photon counting, and the photon counting is expected to identify materials at the same time with taking X-ray photograph by using energy information of X-ray photons. We proposed a direct charge handling method to build a photon counting system with energy information for X-ray imaging. This method operates the charge from the X-ray detector and converts it to encoded digital bit pattern directly without dead time of the front-end circuit. We simulated and built a proposed system to prove operating principals.
Numerical and experimental validation with bifurcation diagrams for a controlled DC–DC converter with quasi-sliding control

This paper presents a stability analysis of a buck converter using a Zero Average Dynamics (ZAD) controller and Fixed-Point Induction Control (FPIC) when the control parameter 𝑁, the reference voltage υref, and the source voltage 𝐸 are changed. The study was based on a previous analysis in which the control parameter was adjusted to 𝑁=1 and the parameter 𝐾𝑠 was changed during the simulation, finding the stability zone and regions with chaotic behavior. Thus, this new study presents the transient and steady-state behaviors and robustness of the buck converter when the control parameter 𝑁 changes. Moreover, numerical simulation results are compared with experimental observations. The results show that the system regulates the output voltage with low error when the voltage is changed in the source E. Besides, the voltage overshoot increases, and the settling time decreases when the control parameter 𝑁 is augmented and the control parameter 𝐾𝑠 is constant. Furthermore, the buck converter controlled by ZAD and FPIC techniques is effective in regulating the output voltage of the circuit even when there are two delay periods and voltage input disturbances.
The Short- and Long-Run Effects of Private Law Enforcement: Evidence from University Police

Over a million people in the United States are employed in private security and law enforcement, yet very little is known about the effects of private police on crime. The current study examines the relationship between a privately funded university police force and crime in a large US city. Following an expansion of the jurisdictional boundary of the private police force, we see no short-term change in crime. However, using a geographic regression discontinuity approach, we find large impacts of private police on public safety, with violent crime in particular decreasing. These contradictory results appear to be a consequence of a delayed effect of private police on crime.
Enhanced ν-optical time domain reflectometry using gigahertz sinusoidally gated InGaAs/InP single-photon avalanche detector

Abstract. Optical time domain reflectometry (OTDR) is one of the most successful diagnostic tools for nondestructive attenuation measurement of a fiber link. To achieve better sensitivity, spatial resolution, and avoid dead-zone in conversional OTDR, a single-photon detector has been introduced to form the photon-counting OTDR (ν-OTDR). We have proposed a ν-OTDR system using a gigahertz sinusoidally gated InGaAs/InP single-photon avalanche detector (SPAD). Benefiting from the superior performance of a sinusoidal gated SPAD on dark count probability, gating frequency, and gate duration, our ν-OTDR system has achieved a dynamic range (DR) of 33.4 dB with 1 μs probe pulse width after an equivalent measurement time of 51 s. This obtainable DR corresponds to a sensing length over 150 km. Our system has also obtained a spatial resolution of 5 cm at the end of a 5-km standard single-mode fiber. By employing a sinusoidal gating technique, we have improved the ν-OTDR spatial resolution and significantly reduced the measurement time.
Mitigation of soil liquefaction using microbially induced desaturation

Soil liquefaction can cause disastrous consequences to buildings and human lives. Regular countermeasures against soil liquefaction are often overly expensive for normal buildings and structures. This could be the major reason that liquefaction induced damage is still widely encountered in large- and mid-size earthquakes in recent years. In this paper, a new method for the mitigation of soil liquefaction using the microbially induced soil desaturation is proposed and tested. The desaturation effect in soil is achieved by the generation of nitrogen gas produced from the microbial denitrification process. Some major issues related to this method are experimentally investigated. These include soil desaturation procedures, shapes and distribution of gas bubbles in soil, mechanical responses and liquefaction resistance of desaturated soils, and stability of gas in soils. The desaturation treatment of soils is made simply by introducing denitrifying bacteria and a desaturation solution into soil pores by mixing, flushing, or injection. The degree of saturation can be reduced as the microbial reaction proceeds. Experimental results show that the final degree of saturation is related to the initial nitrate concentration added to the soil: the higher the concentration of nitrate in the desaturation solution, the lower the degree of saturation that can be achieved. The existence of gas bubbles in soil is evidenced by computer tomography (CT) technology. The CT images reveal that gas is in the form of small pockets which has a size a little larger than the mean size of sand grains. It is shown in the shaking table tests that microbially induced desaturation can effectively improve the liquefaction resistance of soil by showing a much lower pore pressure generation, much smaller volumetric strain, and much smaller settlement of the structure in desaturated soil, as compared with those in saturated soil. Triaxial consolidated undrained tests reveal that the desaturation treatment of soil can improve the undrained shear strength of loose sand. The stability of gas is tested under hydrostatic and water flow conditions. The gas phase is stable under the hydrostatic condition, but unstable under water flow conditions. So measures ought to be taken to prevent steady flow in practice. 概要目 的常规的地基抗液化技术成本较高或实施复杂,因此有大量的工程建设未得到有效的抗液化处理。 本文旨在提出一种新型的、基于微生物诱导减饱和作用的地基液化治理技术,期望能应用到普通的建筑和结构的抗液化治理中。 创新点1. 获得一种基于微生物反硝化过程的砂土减饱和方法;2. 试验验证微生物减饱和法处理砂土的抗液化性能,获得微生物减饱和法处理砂土中的气泡分布形态以及气泡在静水和渗流条件下的稳定性规律。 方 法1. 利用微生物反硝化过程中产生的氮气降低饱和液化砂土的饱和度;2. 利用电脑断层扫描(CT)技术研究微生物减饱和法处理的砂土中气泡的分布形态;3. 利用振动台实验和三轴固结不排水试验研究微生物减饱和法处理的砂土的力学性能和抗液化性能;4. 采用一种自行研制的模型试验(图13)研究微生物减饱和法处理的砂土在静水和渗流条件下气泡的稳定性。 结 论1. 利用微生物反硝化过程可以实现可控的砂土饱和度降低;2. 微生物气泡在砂土中以小空隙的形态存在,小空隙的尺寸略大于砂土的平均粒径;3. 将饱和松砂的饱和度略作降低,其不排水强度和抗液化性能得到显著提升;4. 微生物减饱和法处理的砂土中的气泡在静水条件下是稳定的,但是在稳定渗流条件下会被水流缓慢带走,此时,需要采用一些手段来控制通过减饱和区的渗流。
Accident Analysis and Prevention

There are countless beliefs about the power of music during driving. The last thing one would think about is: how safe is it to listen or sing to music? Unfortunately, collisions linked to music devices have been known for some time; adjusting the radio controls, swapping tape-cassettes and compact-discs, or searching through MP3 files, are all forms of distraction that can result in a near-crash or crash. While the decrement of vehicular performance can also occur from capacity interference to central attention, whether or not music listening is a contributing factor to distraction is relatively unknown. The current study explored the effects of driver-preferred music on driver behavior. 85 young-novice drivers completed six trips in an instrumented Learners Vehicle. The study found that all participants committed at-least 3 driver deficiencies; 27 needed a verbal warning/command and 17 required a steering or braking intervention to prevent an accident. While there were elevated positive moods and enjoyment for trips with driver-preferred music, this background also produced the most frequent severe driver miscalculations and inaccuracies, violations, and aggressive driving. However, trips with music structurally designed to generate moderate levels of perceptual complexity, improved driver behavior and increased driver safety. The study is the first within-subjects on-road high-dose double-exposure clinical-trial investigation of musical stimuli on driver behavior. © 2013 Elsevier Ltd. All rights reserved.
Generation of fractional-order multi-scroll chaotic systems based on Chua's circuits

In this paper, generation of a class of multidirectional saturated chaotic attractors is investigated based on coupled Chua's circuits. The Caputo derivative definition is employed to describe the fractional-order multi-scroll dynamic systems, and a fractional-order chaotic system with 6×6×6×6×6×6 and 9×9×9×9×9×9 grid scroll chaotic attractors are obtained. Simulation results are presented to show the proposed methods.