Miracle-dz/UniFAR-FTUs huggingface dataset:
Temporal domain sub-band video coding with motion compensation

Temporal domain subband coding with motion compensation (MC-SBC) is a new technique of interframe data compression in video coding applications. Perfect reconstruction is possible with one-pixel accuracy for motion parameters and a trivial first-order quadrature mirror filter (QMF). With comparable complexity, even this most simple type of MC-SBC outperforms MC prediction (MC-DPCM) techniques when blockwise motion estimation is used. The concept of MC-SBC is generalized to subpixel accuracy of MC and any even-length (odd-order) QMF filters. Motion estimation is performed in a hierarchical forward-backward procedure which gives better SNR and visual performance results than blockwise-independent estimation. The scheme is extremely error resistant due to its nonrecursive structure; the gain over MC-DPCM is remarkably high, especially in layered coding schemes as they are discussed for ATM video applications. Results of MC-SBC and other interframe coding schemes are compared using two different intrafracture schemes in layered and nonlayered coding applications. <<ETX>>
An extended mixture model for the simultaneous treatment of small‐scale and large‐scale interfaces

The aim of this work is to present a new model based on the volume of fluid method and the algebraic slip mixture model in order to solve multiphase gas–fluid flows with different interface scales and the transition among them. The interface scale is characterized by a measure of the grid, which acts as a geometrical filter and is related with the accuracy in the solution; in this sense, the presented coupled model allows to reduce the grid requirements for a given accuracy. With this objective in mind, a generalization of the algebraic slip mixture model is proposed to solve problems involving small‐scale and large‐scale interfaces in an unified framework taking special care in preserving the conservativeness of the fluxes. This model is implemented using the OpenFOAM® libraries to generate a tool capable of solving large problems on high‐performance computing facilities. Several examples are solved as a validation for the presented model, including new quantitative measurements to assess the advantages of the method. Copyright © 2014 John Wiley & Sons, Ltd.
IMPACTS OF CRISES ON DYNAMIC LINKAGES BETWEEN FINANCIAL AND CAPITAL MARKETS

This paper studies the cointegration and bivariate causality relationships between capital and financial markets for the seven Asian countries, which were badly hit by the Asian Financial Crisis (AFC). Our empirical results show that, before the AFC, all countries, except the Philippines and Malaysia, experienced no evidence of Granger causality between the exchange rates and the stock prices. However, the appearance of the causality, but not the cointegration, between the capital and financial markets becomes stronger during the AFC period. Surprisingly, after the September 11 terrorist attack (911), the causality relationship between these two markets reverts back to normal as in the pre-AFC period and their cointegration relationship is weakened. From our findings, it can be inferred that: First, AFC has a bigger and more direct impact on the causality relationship between the financial and capital markets in Asia; Second, the 911 basically had no impact on the causality relationship between these two markets; and third, the Asian financial and capital markets have become more mature and efficient after the 911 crisis.
Experimental Assessment of Common Crucial Factors That Affect LoRaWAN Performance on Suburban and Rural Area Deployments

LoRaWAN networks might be a technology that could facilitate extreme energy-efficient operation while offering great capacity for suburban and rural area deployment, but this can be a challenging task for a network administrator. Constraints that deform the trade-off triangle of coverage, scalability and energy efficiency need to be overcome. The scope of this study is to review the limitations of the LoRaWAN protocol in order to summarize and assess the crucial factors that affect communication performance, related to data rate allocation, bidirectional traffic and radio spectrum utilization. Based on the literature, these factors correspond mostly to configurable payload transmission parameters, including transmission interval, data rate allocation, requirement for acknowledgements and retransmission. In this work, with simulation experiments, we find that collision occurrences greatly affect channel occupancy. In particular, it was evaluated that collision occurrence is increasingly affected by transmission intervals, which have the most significant negative impact on packet delivery rate (PDR). We then validated that clustering of end nodes in the vicinity of a gateway, taking into account distance and transmission settings, can improve network scalability. This can assure distribution of the total transmission time to end nodes with respect to application-related QoS requirements. Following this clustering approach, we achieved a PDR greater than 0.90 in a simulation setting with 6000 end nodes in a 10 km coverage.
Measurement of thermal conductivity of buried oxides of silicon-on-insulator wafers fabricated by separation by implantation of oxygen technology

In this work, an improved method for measuring the thermal conductivity of buried oxides of a silicon-on-insulator (SOI) wafer is proposed which is simple and effective. Using this method, the thermal conductivity of thin buried oxides with different SOI wafer thicknesses fabricated by separation by implantation of oxygen (SIMOX) technology is measured. It is found that at least in the range of thickness not less than 55 nm, the classically defined thermal conductivity of the SIMOX oxide remains constant (i.e., no size effect is observed) and is equal to 1.06 W m−1 K−1, which is smaller than the 1.4 W m−1 K−1 normally used value in device engineering. The boundary thermal resistance between the Si/SiO2 interface for SIMOX technology is measured accurately here. The results show that this boundary resistance cannot be neglected in calculation of the thermal resistance of SOI devices especially in the case of thinner back oxide.
Transcriptomic Profiling and Pathway Analysis of Mesenchymal Stem Cells Following Low Dose-Rate Radiation Exposure

Low dose-rate radiation exposure can occur in medical imaging, as background from environmental or industrial radiation, and is a hazard of space travel. In contrast with high dose-rate radiation exposure that can induce acute life-threatening syndromes, chronic low-dose radiation is associated with Chronic Radiation Syndrome (CRS), which can alter environmental sensitivity. Secondary effects of chronic low dose-rate radiation exposure include circulatory, digestive, cardiovascular, and neurological diseases, as well as cancer. Here, we investigated 1–2 Gy, 0.66 cGy/h, 60Co radiation effects on primary human mesenchymal stem cells (hMSC). There was no significant induction of apoptosis or DNA damage, and cells continued to proliferate. Gene ontology (GO) analysis of transcriptome changes revealed alterations in pathways related to cellular metabolism (cholesterol, fatty acid, and glucose metabolism), extracellular matrix modification and cell adhesion/migration, and regulation of vasoconstriction and inflammation. Interestingly, there was increased hypoxia signaling and increased activation of pathways regulated by iron deficiency, but Nrf2 and related genes were reduced. The data were validated in hMSC and human lung microvascular endothelial cells using targeted qPCR and Western blotting. Notably absent in the GO analysis were alteration pathways for DNA damage response, cell cycle inhibition, senescence, and pro-inflammatory response that we previously observed for high dose-rate radiation exposure. Our findings suggest that cellular gene transcription response to low dose-rate ionizing radiation is fundamentally different compared to high-dose-rate exposure. We hypothesize that cellular response to hypoxia and iron deficiency are driving processes, upstream of the other pathway regulation.
Enhanced 1.54μm photoluminescence from Er-containing ZnO through nitrogen doping

Nitrogen doping into an erbium (Er)-containing ZnO specimen through the N+ irradiation and the subsequent annealing in air was found to increase the photoluminescence (PL) intensity around 1. 54μm by about 40 times. The existence of nitrogen in the specimen was proved firmly by means of the N14(d,α)C12 nuclear reaction analysis. Further, the Ne+ irradiation was conducted instead of the N+ irradiation, but no effect was observed in the PL spectra. So, it was concluded that the substitution of N for O could modify the local structure around Er3+, resulting in the surprisingly large enhancement of the PL intensity.
COUPLING INTEGRABLE COUPLINGS

Integrable couplings are presented by coupling given integrable couplings. It is shown that such coupled integrable couplings can possess zero curvature representations and recursion operators, which yield infinitely many commuting symmetries. The presented zero curvature equations are associated with Lie algebras, each of which has two sub-Lie algebras in form of semi-direct sums of Lie algebras.
Non-linear systems identification using radial basis functions

This paper investigates the identification of discrete-time non-linear systems using radial basis functions. A forward regression algorithm based on an orthogonal decomposition of the regression matrix is employed to select a suitable set of radial basis function centers from a large number of possible candidates and this provides, for the first time, fully automatic selection procedure for identifying parsimonious radial basis function models of structure-unknown non-linear systems. The relationship between neural networks and radial basis functions is discussed and the application of the algorithms to real data is included to demonstrate the effectiveness of this approach.
Sharp $L^p$-weighted Sobolev inequalities

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A simultaneously phase-matched tandem optical parametric oscillator

We report the theoretical analysis of a simultaneously phase-matched tandem optical parametric oscillator (STOPO) in which the principal OPO generates a signal which pumps a secondary OPO. Both OPO interactions are assumed to be phase-matched in a single crystal. The cavity has high Q for the signal produced by the principal OPO and has lower Q for the signal of the secondary OPO. The pump and the two idler frequencies are not resonated. The five waves undergoing nonlinear mixing are assumed to be nondegenerate in either frequency or polarization. We show that the useful output, consisting of the two idlers and the signal of the secondary OPO, can be produced with high efficiency over a large dynamic range in the pump intensity. We discuss the tuning with temperature and grating period of a STOPO based on periodically poled LiNbO/sub 3/ pumped at 1.064 /spl mu/m. We present results based on both plane-wave modeling and modeling in three spatial dimensions.
Assessing the Short-Term Forecast Capability of Nonstandardized Surface Observations Using the National Digital Forecast Database (NDFD)

The number of surface observations from nonstandardized networks across the United States has appreciably increased the last several years. Automated Weather Services, Inc. (AWS), maintains one example of this type of network offering nonstandardized observations for ;8000 sites. The present study assesses the utility of such a network to improve short-term (i.e., lead times ,12 h) National Digital Forecast Database (NDFD) forecasts for three parameters most relevant to the energy industry—temperature, dewpoint, and wind speed. A 1-yr sample of 13 AWS sites is chosen to evaluate the magnitude of forecast improvement (skill) and influence of physical location (siting) on such improvements. Hourly predictions are generated using generalized additive modeling (GAM)—a nonlinear statistical equation incorporating a predetermined set of the most significant AWS and NDFD predictors. Two references are used for comparison: (i) persistence climatology (PC) forecasts and (ii) NDFD forecasts calibrated to the AWS sites (CNDFD). The skill, measuredvia the percentimprovement(reduction) in themeanabsoluteerror(MAE),offorecastsgenerated by the study’s technique (CNDFD1) is comparable (,5%) to PC for lead times of 1‐3 h for dewpoint and wind speed. Skill relative to PC slowly increases with lead time, with temperature exhibiting the greatest relative-to-PC skill (;30% at 12 h). When compared to baseline CNDFD forecasts, the MAE of the generated CNDFD1 forecasts is reduced 65% for temperature and dewpoint at the 1-h lead time. An exponential drop in improvement occurs for longer lead times. Wind speed improvements are notably less, with little skill (,5%) demonstrated for forecasts beyond 4 h. Overall, CNDFD1 forecasts have the greatest accuracy relative to CNDFD and PC for the middle (3‐7 h) lead times tested in the study. Variations in CNDFD1 skill exist with respect to AWS location. Tested stations located in complex terrain generally exhibit greater skill relative to CNDFD than the 13-station average for temperature (and, to a lesser degree, dewpoint). RelativetoPC,however,thesamesubsetofstationsexhibitsskillbelowthe13-stationaverage.No conclusive relationship can be made between CNDFD1 skill and the sample stations located near water.
Hubungan antara Self-Compassion dengan Resiliensi pada Remaja Panti Asuhan Bunda Pangkalan Balai

This study aims to determine the relationship between self-compassion and resilience in the Bunda Pangkalan Balai orphanage. This research method is correlational quantitative. The research subjects were 40 students of the orphanage who were selected using the total sample technique. The instrument used is a self-compassion scale and a resilience scale. The results of data analysis using the Pearson product moment analysis technique (SPSS ver.26 for windows) showed that there was a relationship between self-compassion and resilience in the youth at the Bunda Pangkalan Balai orphanage with a correlation coefficient I of 0.439 with a significant value of 0.022, which means the significance value is < 0.05. These results indicate that there is a relationship between self- compassion and resilience in the youth of the Bunda Pangkalan Balai orphanage. With these results, the hypothesis proposed in this study is accepted.
Safety, Tolerability, and Pharmacokinetics of Benralizumab: A Phase 1, Randomized, Single-Blind Study of Healthy Chinese Participants

Purpose Biological therapies targeting eosinophils have been shown to be effective in treating patients with severe eosinophilic asthma. Benralizumab (Fasenra®, AstraZeneca) is a humanized monoclonal antibody binding to the alpha subunit of the interleukin-5 receptor, which rapidly depletes eosinophils via antibody-dependent cellular cytotoxicity. The aim of this Phase 1 study was to assess the safety, tolerability, and pharmacokinetics of benralizumab in healthy Chinese individuals. Materials and Methods In this randomized, single-blind study (NCT03928262), healthy Chinese adult participants aged 18 to 45 years, weighing 50 to 100 kg, were randomized 1:1:1 to receive a single subcutaneous (SC) injection of benralizumab 10 mg, 30 mg, or 100 mg in the upper arms on Day 1. Safety was monitored throughout the study (up to Day 85), and blood samples were taken to determine serum benralizumab concentrations and for detection of anti-drug antibody. A non-compartmental analysis was conducted to estimate the pharmacokinetic parameters. Results Thirty-six healthy participants were enrolled, 12 in each dose group (mean [SD] age 26 [6] years). Following a single SC injection of benralizumab, 13 adverse events were reported by 10 participants (28%), with one mild injection-site reaction assessed as related. The mean serum benralizumab concentrations increased in a dose proportional manner, followed by exponential decreases. The mean terminal half-lives were 15.1 days for the 10 mg dose, 14.4 days for the 30 mg dose, and 15.4 days for the 100 mg dose. All doses resulted in near-complete depletion of eosinophils on Day 2, which was maintained throughout the study to Day 85. Conclusion A single SC injection of benralizumab was well tolerated by healthy Chinese participants, with no new or unexpected safety findings. The pharmacokinetics of benralizumab in Chinese participants was dose-proportional and consistent with those of non-Chinese participants observed in previous studies. Clinical Trial Registration NCT03928262 (https://clinicaltrials.gov/ct2/show/NCT03928262)
Cross-Cultural Adaptation and Psychometric Properties of the Spanish Version of the OPQOL-Brief

Background: Ageing and its consequences on quality of life is one of the main issues to be addressed by public organizations; therefore the development of tools for its evaluation is a priority issue to orientate lines of action. Therefore, the objective of this research is to carry out cross-cultural adaptation and present the psychometric properties of the Spanish version of the Older People’s Quality of Life Questionnaire-Brief (OPQOL-Brief). Methods: a cross-cultural adaptation was carried out together with a process of translation and back-translation of the scale. The OPQOL-Brief and a sociodemographic questionnaire were administered to 120 older adults aged over 65 from a healthcare setting in the region of Extremadura. Results: the exploratory analysis revealed a factor structure through a matrix of polychoric correlations divided in two intercorrelated factors, consisting of 12 items and with excellent sample adequacy indices (KMO = 0.846’; Bartlett test = 1268.1; p = 0.000). Then, the confirmatory factor analysis established the definitive model with exceptional goodness-of-fit indices (NNFI = 0.99; CFI = 0.99; CMIN/DF = 0.96; Ρ (χ2) = 0.22; RMSEA = 0.037 and RMSR = 0.040). Finally, Cronbach’s alpha and McDonald’s omega for internal consistency reported good values of 0.830 and 0.851, respectively. Conclusion: our findings show that the OPQOL-Brief exhibits a solution with 12 elements and related constructs, providing stable goodness-of-fit indicators as well as good and remarkable consistency ratings.
The Effect of Green Human Resources Management Practices on Employees’ Affective Commitment and Work Engagement: The Moderating Role of Employees’ Biospheric Value

Organizational Sustainability is an increasingly important movement in the business world because of its social impact and also for the obligations imposed by state agendas and programs by global entities, such as the United Nations. At the forefront of such a movement is the Human Resources function, given its boundary activities with several critical internal and external stakeholders. The term Green Human Resource Management (GHRM) has been used to describe people management with a focus on green issues. The main objective of this research was to explore the relationship between personal values associated with sustainable behaviors (altruistic, biospheric, egoistic, and hedonic values), organizational outcomes such as engagement and commitment, and GHRM. A questionnaire was prepared and used to collect 532 responses from employees from various organizations. Results show that of the four personal values only the biospheric one moderates the relationship between GHRM practices and affective commitment so that the relationship between HRM and affective commitment is stronger when biospheric values score higher. This is an important finding, as it shows that when people value the biosphere, the effect of GHRM practices on affective commitment and work engagement is stronger than when people value other matters.
Mechanisms of ADC Toxicity and Strategies to Increase ADC Tolerability

Simple Summary Antibody-drug conjugates (ADC) are a rapidly expanding class of anti-cancer drugs, with twelve agents in current clinical use. Despite recent successes, many ADCs fail during clinical development due to excessive toxicities and unfavorable risk-benefit profiles. Even for those ADCs that have been approved for clinical use, a substantial fraction of treated patients require dose reduction, treatment delays, or treatment discontinuation due to intolerable ADC-associated toxicity. In this report, we review the mechanisms contributing to the clinical toxicity of ADCs, and we discuss strategies to improve ADC tolerability. Abstract Anti-cancer antibody-drug conjugates (ADCs) aim to expand the therapeutic index of traditional chemotherapy by employing the targeting specificity of monoclonal antibodies (mAbs) to increase the efficiency of the delivery of potent cytotoxic agents to malignant cells. In the past three years, the number of ADCs approved by the Food and Drug Administration (FDA) has tripled. Although several ADCs have demonstrated sufficient efficacy and safety to warrant FDA approval, the clinical use of all ADCs leads to substantial toxicity in treated patients, and many ADCs have failed during clinical development due to their unacceptable toxicity profiles. Analysis of the clinical data has demonstrated that dose-limiting toxicities (DLTs) are often shared by different ADCs that deliver the same cytotoxic payload, independent of the antigen that is targeted and/or the type of cancer that is treated. DLTs are commonly associated with cells and tissues that do not express the targeted antigen (i.e., off-target toxicity), and often limit ADC dosage to levels below those required for optimal anti-cancer effects. In this manuscript, we review the fundamental mechanisms contributing to ADC toxicity, we summarize common ADC treatment-related adverse events, and we discuss several approaches to mitigating ADC toxicity.
Characterization of a microstructured Zeonex terahertz fiber

We report on the characterization of Zeonex polymer in the terahertz (THz) region and the fabrication and characterization of a microstructured polymer fiber made of Zeonex. We demonstrate single-mode propagation with highly efficient coupling into the fiber close to the theoretical limit of 80% using specially designed lenses. The THz time domain measurements allow the loss and dispersion properties of the fiber to be determined, showing that for the current fiber the losses are only caused by the material loss. The phase refractive index is calculated from experimental data and compared to values predicted by scalar and vectorial simulations. Results for the dispersion parameter β2 for a THz microstructured fiber are presented for the first time to our knowledge.