Miracle-dz/UniFAR-FTUs huggingface dataset:
Modified balanced random forest for improving imbalanced data prediction

This paper proposes a Modified Balanced Random Forest (MBRF) algorithm as a classification technique to address imbalanced data. The MBRF process changes the process in a Balanced Random Forest by applying an under-sampling strategy based on clustering techniques for each data bootstrap decision tree in the Random Forest algorithm. To find the optimal performance of our proposed method compared with four clustering techniques, like: K-MEANS, Spectral Clustering, Agglomerative Clustering, and Ward Hierarchical Clustering. The experimental result show the Ward Hierarchical Clustering Technique achieved optimal performance, also the proposed MBRF method yielded better performance compared to the Balanced Random Forest (BRF) and Random Forest (RF) algorithms, with a sensitivity value or true positive rate (TPR) of 93.42%, a specificity or true negative rate (TNR) of 93.60%, and the best AUC accuracy value of 93.51%. Moreover, MBRF also reduced process running time.
The lncRNA HCG4 regulates the RIG-I-mediated IFN production to suppress H1N1 swine influenza virus replication

Influenza A virus (IAV) non-structural protein 1 (NS1) is a virulence factor that allows the virus to replicate efficiently by suppressing host innate immune responses. Previously, we demonstrated that the serine (S) at position 42 of NS1 in H1N1 swine influenza virus (SIV) is a critical residue in interferon (IFN) resistance, thus facilitating viral infections. Here, by lncRNA-seq, a total of 153 differentially expressed lncRNAs were identified, and the lncRNA HCG4 was selected due to its significantly higher expression after infection with the NS1 S42P mutant virus. Overexpression of HCG4 enhanced IFN-β production and suppressed SIV infection, highlighting the potential antiviral activity of HCG4 against SIV. Further investigation suggested that HCG4 served as a positive feedback mediator for RIG-I signaling. It alleviated the inhibitory effect on RIG-I K63-linked ubiquitination by NS1 protein, thereby resulting in an increase in RIG-I-mediated IFN production. Taken together, our findings demonstrate that HCG4 modulates the innate immune response to SIV infection through K63-linked RIG-I ubiquitination, providing insights into the role of lncRNAs in controlling viral infections.
The Clinical Course of Paranasal Sinus Mucocoeles—A Retrospective Case Series

Paranasal sinus mucocoeles can be secondary to chronic rhinosinusitis and can result in intra-orbital and intra-cranial complications requiring surgical management. The natural history of conservatively managed mucocoeles is not well established. We aimed to quantify the proportion of radiologically identified paranasal sinus mucocoeles resulting in complications over 10 years. We retrospectively reviewed anonymised data on radiologically diagnosed mucocoeles between 2011 and 2021 at two UK hospitals. We collected data on age at presentation, extent of sinus involvement, management and complications. We identified 60 patients with mucocoeles, of which 35 (58%) were incidental findings from radiological investigations. The mean age was 58 years. Fifteen patients (25%) were managed surgically and one presented with recurrence following surgery. Overall, six patients (10%) had an intra-orbital extension of their mucocoele and three (5%) had an intra-cranial extension. There was no difference in the rates of intra-cranial extension between conservative and surgical cases but surgical cases included a higher rate of intra-orbital extensions (27% vs. 4%, p = 0.01). The proportion of patients requiring surgical intervention in this study is low. Incidental and asymptomatic mucocoeles have a relatively benign disease course and selected uncomplicated cases can be considered for conservative management with serial scanning at 12 months.
Moldenhawera congestiflora: a new species of Leguminosae from the Brazilian Atlantic Forest

Moldenhawera is a small genus of Caesalpinioideae (Leguminosae), characterized by biramous (T-shaped) trichomes, compoundly pinnate stipules, hypanthium absence, clawed petals, dimorphic androecium, and anther connective of the fertile stamen pubescent. Moldenhawera congestiflora, a new species from the Atlantic Forest in Bahia State, Brazil is described and illustrated. It is distinguished from other species of the M. sect. Brasilianae by the combination of its tree habit, leaves relatively long (rachis > 24 cm long), leaflets elliptic to oblong with apex acuminate, flower buds densely grouped at the inflorescence apex, flowers pentamerous, petal blades relatively small (6–8 × 4–5 mm), and base of fertile stamen villous. Additionally we provide a new identification key for the section Brasilianae.
A cross-sectional analysis of the relationship between ischemic stroke and uric acid in young people in highland areas

Objective To investigate the relationship between serum uric acid (SUA) levels and ischemic stroke in young patients in the Ganzi Tibetan plateau area. Methods A cross-sectional survey was undertaken from January 2020 to June 2023 involving young patients (age: 15–45 years) diagnosed with ischemic stroke. The survey was conducted at the Department of Internal Medicine of the People’s Hospital of Derong County, Ganzi Prefecture. The participants underwent a comprehensive assessment, including questionnaire surveys, physical examinations, laboratory tests, and head computed tomography (CT) examinations. Based on the tertiles of serum uric acid (SUA) levels, the patients were stratified into three groups. Furthermore, stroke severity was classified into mild (1–4 points), moderate (5–15 points), and severe (>15 points) categories using the National Institute of Health Stroke Scale. Results The severe stroke group exhibited higher levels of age, glucose, systolic blood pressure, serum triglyceride, low-density lipoprotein cholesterol, and serum uric acid (SUA) compared to the mild stroke group (P < 0.05). Furthermore, the likelihood of male sex, advanced age, smoking, and a family history of stroke, diabetes mellitus, and heart disease were significantly elevated in the severe stroke group compared to the moderate stroke group (P < 0.05). Multivariate logistic regression analysis conducted on young adults residing in highland areas revealed a significant association between SUA levels and the risk of stroke. Conclusion Elevated SUA levels serve as a distinct risk factor for the development of a major stroke in young patients in highland areas. At SUA levels of 320.56 mol/L, the risk of a moderate-to-severe stroke is noticeably elevated.
Keberkesanan Pembelajaran Teradun Melalui Penggunaan Aplikasi Web 2.0

In line with the rapid development of information and communication technology (ICT), the Ministry of Education Malaysia emphasized the use of technology in teaching and learning activities to make learning experiences more meaningful to students. Institutions of higher learning are encouraged to implement blended learning that can be supported by the use of Web 2.0 applications. The purpose of this study is to explore the effectiveness of blended learning through Web 2.0 applications in a public university. The study utilized qualitative data collection techniques such as interviews and focus group discussions. Subjects of the study consisted of two lecturers and six undergraduate students. The study have identified the steps in applying Web 2.0 in blended learning including preparation, recognizing students’ basic knowledge and experience, identifying the level of interactivity, using appropriate assessment strategies, and reflection. Blended learning with the use of Web 2.0 application is effective in increasing the interaction between lecturers and students, increasing student engagement, enhancing student understanding of a topic, creating a fun learning environment, contributing to self-learning, changing students’ attitude and improving their skills in using ICT. Pedagogy, lecturers, students and infrastructure are the four key aspects that determine the sustainability of Web 2.0 applications in blended learning.
Intercropping Systems to Modify Bioactive Compounds and Nutrient Profiles in Plants: Do We Have Enough Information to Take This as a Strategy to Improve Food Quality? A Review

Various environmental, food security and population health problems have been correlated with the use of intensive agriculture production systems around the world. This type of system leads to the loss of biodiversity and natural habitats, high usage rates of agrochemicals and natural resources, and affects soil composition, human health, and nutritional plant quality in rural areas. Agroecological intercropping systems that respect agrobiodiversity, on the other hand, can significantly benefit ecosystems, human health, and food security by modifying the nutritional profile and content of some health-promoting bioactive compounds in the species cultivated in this system. However, research on intercropping strategies focuses more on the benefits they can offer to ecosystems, and less on plant nutrient composition, and the existing information is scattered. The topic merits further study, given the critical impact that it could have on human nutrition. The aim of this review is therefore to collect viable details on the status of research into the profile of nutrients and bioactive compounds in intercropping systems in different regions of the world with unique mixed crops using plant species, along with the criteria for combining them, as well as the nutrients and bioactive compounds analyzed, to exemplify the possible contributions of intercropping systems to food availability and quality.
PKD1L1 Is Involved in Congenital Chylothorax

Besides visceral heterotaxia, Pkd1l1 null mouse embryos exhibit general edema and perinatal lethality. In humans, congenital chylothorax (CCT) is a frequent cause of fetal hydrops. In 2021, Correa and colleagues reported ultrarare compound heterozygous variants in PKD1L1 exhibiting in two consecutive fetuses with severe hydrops, implicating a direct role of PKD1L1 in fetal hydrops formation. Here, we performed an exome survey and identified ultrarare compound heterozygous variants in PKD1L1 in two of the five case–parent trios with CCT. In one family, the affected carried the ultrarare missense variants c.1543G>A(p.Gly515Arg) and c.3845T>A(p.Val1282Glu). In the other family, the affected carried the ultrarare loss-of-function variant (LoF) c.863delA(p.Asn288Thrfs*3) and the ultrarare missense variant c.6549G>T(p.Gln2183His). Investigation of the variants’ impact on PKD1L1 protein localization suggests the missense variants cause protein dysfunction and the LoF variant causes protein mislocalization. Further analysis of Pkd1l1 mutant mouse embryos revealed about 20% of Pkd1l1−/− embryos display general edema and pleural effusion at 14.5 dpc. Immunofluorescence staining at 14.5 dpc in Pkd1l1−/− embryos displayed both normal and massively altered lymphatic vessel morphologies. Together, our studies suggest the implication of PKD1L1 in congenital lymphatic anomalies, including CCTs.
Gender differences in borderline personality disorder: a narrative review

Borderline personality disorder (BPD) is a severe and complex mental disorder that traditionally has been found to be more frequent in the female gender in clinical samples. More recently, epidemiological studies have provided conflicting data about the prevalence of borderline disorder in the two genders in community samples. In order to explain this heterogeneity, some authors hypothesized the presence of a bias in the diagnostic criteria thresholds (more prevalent in one gender than another), in the population sampling (community versus clinical), in the instruments of evaluation (clinician versus self-report measures), and in the diagnostic construct of BPD. Beyond the question of the different prevalence of the disorder between genders, the debate remains open as to how personality and clinical characteristics, and attitude toward treatments express themselves in the two genders. This narrative review is aimed to provide an updated overview of the differences among genders in BPD in terms of diagnosis, temperamental and clinical characteristics, comorbidities, findings of neuroimaging, and treatment attitudes. Studies that specifically investigated the gender differences in BPD patients are rather limited. Most of the investigations did not consider gender as a variable or were characterized by a significant imbalance between the two genders (more commonly in favor the female gender). The main results indicated that men were more likely to endorse the criteria “intense and inappropriate anger” and “impulsivity,” whereas women endorsed the criteria “chronic feelings of emptiness,” “affective instability,” and “suicidality/self-harm behaviors. ” These findings reflect differences in temperament and symptoms of the two genders. Other relevant differences concern pattern of comorbidity, specific neurobiological mechanisms and attitude to treatments. Main limitations were that only one database was searched, time of publications was limited, non-English manuscripts were excluded, and the quality of each paper was not commented.
Pengembangan Game 2D Platformer Berbasis Microbit Menggunakan Unity

This research aims to develop a 2D platformer game using the Microbit platform and Unity as the development tools. The Microbit serves as the controller with various sensors and computational capabilities. The development process starts with designing the game concept, including level design, characters, and mechanics. Unity is used to create levels, game logic, and connect the Microbit to the game. Users can control the character through the sensors and buttons on the Microbit. Testing involves participants to measure the game's quality and effectiveness and gather feedback. The collected data is used to analyze the strengths and weaknesses of the game and make iterations to enhance the gaming experience. As a result, the researchers have created a game that can be controlled via Microbit, enriching the gaming experience.
An Unusual Cause of Longstanding Diarrhea

Colchicine is an alkaloid drug used in multiple medical conditions. It has a narrow therapeutic index, and gastrointestinal symptoms can occur at the beginning or after long-term therapy. Unintentional toxicity is common and has a high mortality rate when missed. Histopathologic recognition is challenging, and timely identification is conducted to improve patients' outcomes. We describe the case of a 77-year-old female who presented to the emergency room for dehydration, longstanding diarrhea, and weight loss. Upper and lower endoscopies showed erythematous mucosa without bleeding in the gastric antrum and an unremarkable duodenum and colon. Duodenal biopsies demonstrated partial villous atrophy with elongated glands and numerous arrested ring mitoses, consistent with colchicine toxicity.
A Rare Case of Cavernous Intramuscular Hemangioma of the Forearm

Cavernous intramuscular hemangiomas are a part of a group of rare benign tumors. This case report outlines a unique instance involving a 72-year-old patient who sought medical advice at our department due to a progressively enlarging mass in the posterior aspect of her right forearm. Physical examination revealed a painless, mobile mass with no apparent skin abnormalities. Radiographs showed normal results, and an MRI raised suspicion of a fibrous tumor. A subsequent biopsy confirmed the diagnosis of cavernous hemangioma. The patient underwent a total excision procedure, resulting in favorable outcomes with no observed functional impairment or tumor recurrence over four years. This case is notable for its singularity, involving both the advanced age of the patient and the uncommon location of the tumor.
A 1DVAR retrieval applied to GMI: Algorithm description, validation, and sensitivities

A fully physical, 1‐D variational inversion algorithm (1DVAR) has been developed to simultaneously retrieve total precipitable water (TPW), 10 m wind speed, and cloud liquid water path (CLWP) over ocean. Results presented are for the Global Precipitation Measurement Microwave Imager (GMI), but the algorithm is adaptable to any microwave imager. The Colorado State University 1DVAR is novel in that the observation error covariances are not assumed to be zero and empirical orthogonal functions are utilized to retrieve the structure of the water vapor profile, aided by GMI's high‐frequency channels. Validation against radiosonde and ocean buoy observations demonstrates a near zero bias for wind speed and a small positive bias for water vapor, respectively, with RMS errors that rival those of benchmark products. RMS errors against validation are 2.6 mm and 1.2 m/s for TPW and wind speed. No calibration adjustments were made to achieve these results, and no “truth” data were used to train the algorithm. The advantages of this fully physical inversion are its adaptability, transparency, and full description of retrieval errors. Sensitivities of the algorithm are explored in detail.
Deception Against Near-Field Synthetic Aperture Radar Using Networked Jammers

We propose a new deceptive jamming method using networked receivers to perform deceptive jamming against multimode synthetic aperture radar. Using multiple receivers to measure the time difference of beam arrival, we solve the instantaneous modulation parameters precisely via linear equations. We then solve the time delays and frequency offsets of the deceptive signal without approximation to avoid accumulating electronic reconnaissance errors with traditional deceptive methods. Additionally, we design the distribution of receivers to minimize the condition number, reducing our method's sensitivity to measurement error. Simulation results prove the effectiveness of the proposed method.
Comparative evaluation of sesame oil obtained with microwave-assisted enzymatic extraction and conventional solvent extraction

This research investigates the impact of extraction methods on sesame seed oil, specifically comparing traditional Soxhlet extraction (SE) with the relatively newer Microwave-Assisted Enzymatic Extraction (MAEE). While SE exhibited a higher oil yield (46.13%) compared to MAEE (45.20%), the difference was not statistically significant, suggesting MAEE as a viable alternative to conventional methods. These findings align with prior research, emphasizing SE's efficiency in oil extraction. SE, involving solvent circulation, yielded a darker oil due to increased pigment extraction. Specific gravity values showed a slight decrease in MAEE (0.915) compared to SE (0.917), yet the difference was not significant. The refractive index (RI) of MAEE-extracted oil (1.463) was significantly higher, indicating potential advantages in oil quality. MAEE's transparency to monochromatic light suggests a preference for obtaining high-quality oil from sesame seeds. Free Fatty Acid (FFA) values were higher in MAEE (1.33%) than SE (1.19%), signifying potential benefits in oil quality and stability. The use of enzymes in MAEE may mitigate oxidation and degradation during extraction, contributing to lower FFA values. Saponification values were significantly higher in SE (197.34) compared to MAEE (192 mg KOH/g), attributed to solvents extracting a wider range of fatty acids. The degree of saturation, determined by iodine value, was significantly higher in MAEE (111.19) than SE (107.6), possibly due to enzymatic hydrolysis resulting in a higher yield of unsaturated fatty acids. Peroxide values were non-significantly different between MAEE (1.79 meqO 2 /kg) and SE (1.72 meqO 2 /kg), suggesting oxidation in sesame oil is influenced more by intrinsic factors than extraction technique. MAEE's potential advantage lies in improved shelf-life and stability, attributed to its higher antioxidant content. MAEE presented as a promising alternative with potential benefits in terms of oil quality, transparency, and stability.
Hybrid heterogeneous phantoms for biomedical applications: a demonstration to dosimetry validation

Phantoms simultaneously mimicking anatomical and optical properties of real tissues can play a pivotal role for improving dosimetry algorithms. The aim of the paper is to design and develop a hybrid phantom model that builds up on the strengths of solid and liquid phantoms for mimicking various anatomical structures for prostate cancer photodynamic therapy (PDT) dosimetry validation. The model comprises of a photosensitizer-embedded gelatin lesion within a liquid Intralipid prostate shape that is surrounded by a solid silicone outer shell. The hybrid phantom was well characterized for optical properties. The final assembled phantom was also evaluated for fluorescence tomographic reconstruction in conjunction with SpectraCure’s IDOSE software. The developed model can lead to advancements in dosimetric evaluations. This would improve PDT outlook as a clinical treatment modality and boost phantom based standardization of biophotonic devices globally.
Need‐supportive leadership behaviors and sickness absence among employees: The mediating role of basic psychological need satisfaction

Research exploring relationships between leadership behaviors and sickness absence is scarce. Grounded in self‐determination theory (SDT), the present study examined: (i) the relationship between need‐supportive leadership and sickness absence; and (ii) whether satisfaction of the basic psychological needs mediates the relationship between need‐supportive leadership and sickness absence. Municipal employees (n = 347, 78% women, age span = 19–66 years) provided baseline data on perceived need‐supportive leadership and reported their need satisfaction at work 8 weeks later. Sickness absence data were obtained from municipality records. Two‐part regression models showed that need‐supportive leadership was negatively associated with sick days (b = −0.28, 95% CI [−0.45, −0.11]). Need‐supportive leadership had an indirect effect on the number of sick days through a composite score of need satisfaction (ab = −1.96, 95% CI [−5.11, −0.12]). Mediation models with each need separately indicated that autonomy (ab = −2.12, 95% CI [−5.33, −0.23]) and relatedness (ab = −1.33, 95% CI [−3.41, −0.11]) mediated the relationship between need‐supportive leadership and number of sick days. Need‐supportive leadership and need satisfaction at work may function as protective factors that provide followers with opportunities to deal with symptoms of ill health and reduce the risk of prolonged sickness absence.
Design and Optimization of High Performance P3HT: PCBM Polymer Solar Cell Using P3HT Buffer Layer

In this paper, a novel structure of multilayer organic photovoltaic cell has been designed and simulated. The integration of Poly(3-hexylthiophene-2,5-diyl) (P3HT) buffer layer and Poly(9,9-bis(3’-(N,N-dimethyl) N- ethylammoinium propyl-2,7-fluorene)-alt-2,7-(9,9 dioctyl fluorene)) dibromide (PFN:BR) electron transport layer (ETL) in the proposed solar cell has improved the performance significantly. The various performance measuring parameters like power conversion efficiency (PCE), short circuit current (Jsc), open circuit voltage (Voc), fill factor (FF), quantum efficiency (QE) have improved significantly. Furthermore, the effect of different layer thickness, the density of traps $N_{t}$ and temperature on the proposed solar cell has been studied and the optimum value has been obtained. It has been observed that after optimizing the different parameters of the proposed structure, the performance measuring parameters shows an improvement of 14%, 33.3%, 200% and 300% in Voc FF, Jsc and PCE respectively over the reported organic solar cells. Further, a QE of about 90% is achieved in the proposed structure.