Miracle-dz/UniFAR-FTUs huggingface dataset:
Anti-inflammatory, antibacterial and antioxidant activities of Chenopodium ambrosioides L. (Chenopodiaceae) extracts

Objective: Chenopodium ambrosioides is an aromatic plant widely used in the Togolese traditional medicine. However, little is known about its pharmacological properties. The present study aimed to investigate the anti-inflammatory, antibacterial and antioxidant activities of its extracts. Methodology and results: Thus, an ethnopharmacological survey was undertaken in Kara town in the northern part of Togo to assess the main uses in the traditional medicine and Gas Chromatography coupled with Mass Spectral Analysis (GC-MS) was used to identify several compounds in the extracts. Antioxidant activity was evaluated by FRAP, ABTS, DPPH methods. Anti-inflammatory and antimicrobial activities were assessed by soybean lipoxygenase inhibition and in vitro broth micro dilution techniques, respectively. Propidium iodide cell death was evaluated by flow cytometry and in vivo toxicity was assessed using wistar rats. The ethnopharmacological survey revealed that traditional healers use C. ambrosioides to treat malaria, intestinal worms and inflammation in addition to healing wounds. The hydroethanolic extract had high content of total phenols (324.80±17.30 µgEAG/mg) and flavonoids (63.20±8.70 µgEQ/mg), however the highest antioxidant, antimicrobial and antiinflammatory activities were obtained with the essential oil. GC-MS analysis leads to identification of hydrocarbon monoterpenes such as 2carene, ortho-cymene and α-terpinene as the major components of the essential oil. All the tested extracts induced cell death (14.60 ± 9.23% at 2 µL/mL, 72.64 ± 15.92% at 200µL/mL and 89.50 ± 7.16 at 100 mg/mL for essential oil, hydrosol and hydroethanolic extract, respectively). Conclusion and application of results. The present study demonstrated various pharmacological activities of hydroethanolic extract, essential oil and hydrosol of leaves of Chenopodium ambrosioides. The essential oil had antioxidant, antimicrobial and antiinflammatory activities and could be the most active component of the leaves of Chenopodium ambrosioides. Our findings highlighted perspectives for the discovery of new medicinal molecules derived from plant extrats and confirmed certain practices of traditional healers. Keywords: Chenopodium ambrosioides, extract, pharmacological activities
Cancer Cervix and Human Papilloma Virus (HPV) among Women Attending Gynecological Out Clinic Patients Al-Azhar University Hospitals: Newly Screening Technique

Background: Most incidences of cervical cancer are caused by the human papillomavirus (HPV), which can be prevented with a vaccination. In around 90% of cases, HPV infections have no symptoms and disappear on their own within two years. In certain situations, however, an HPV infection might remain and cause warts or precancerous lesions. HPV causes nearly all cervical cancer cases; two strains, HPV16 and HPV18, accounting for 70% of cases. Objectives: The study was designed to re-assess the prevalence of HPV infection among women attending the Gynecological Outpatient Clinic Al-Azhar University Hospitals using the new liquid-based cytology technique and our results provide important information for public health authorities considering HPV prevention in Egypt. Subjects and methods: Our study was conducted on 1000 gynecological patients attending Al-Azhar University Hospitals between March 2021 and December 2021. Their ages ranged from 35 70 years old. Cervical samples were collected by a gynecologist using a cytobrush and placed in a liquid-based cytology medium (using the DC LBC from GZLBP) for the presence of HPV DNA using Linear Array HPV genotyping at Cytolab Laboratory, Cairo, Egypt. Results Among 1000 women who underwent the LBC test, 97 women were positive for HPV DNA findings (9.7%), while the rest of women 903 were test free (90.3%). 57 cases (58.7%) of positive women showed different degrees of cervical intra-epithelial neoplasia CIN. Conclusion: The essential need for a proper screening system for cervical pathologies and further multi-central randomized studies are strongly recommended through our study.
Analisis Faktor-Faktor yang Memengaruhi Leverage dan Profitabilitas Perusahaan

A firm’s leverage and profitability are two significant aspects of overall firm management. This study mainly aims at examining and analyzing the determinants of leverage and profitability in Indonesian mining firms listed by including both trade-off theory and pecking order theory approaches. Secondary data as sample has been collected for 26 Indonesian mining firms listed in Indonesian stock exchange (IDX), for the period of 9 years from 2010 to 2018. Firm’s size, asset tangibility, asset growth, and liquidity have been selected as exogenous variables to examine their effect on endogenous variables, i.e., leverage and profitability. Path analysis technique was employed to analyze the research data. The results indicate that leverage exerts negative impact on firm profitability. The finding results of this study provides great insights for Indonesian mining firm management, to integrate the financial leverage models in their financial decision to obtain optimum firm profitability.
Near Optimal Learning-Driven Mechanisms for Stable NFV Markets in Multitier Cloud Networks

More and more 5G and AI applications demand flexible and low-cost processing of their traffic through diverse virtualized network functions (VNFs) to meet their security and privacy requirements. As such, the Network Function Virtualization (NFV) market has been emerged as a major service market that allows network service providers to trade their network services among customers. Since each service market usually involves complex interplays among players with different roles, efficient mechanisms that guarantee stable and efficient operations of the NFV market are urgently needed. One fundamental problem in the NFV market is how to maximize the social welfare of all players so that all players have incentives to participate in the activities of the market. In this paper, we first formulate a novel social welfare maximization problem in an NFV market of a multi-tier edge cloud network, with the aim to maximize the total revenue collected from all players, and we implement VNF services on Virtual Machines (VMs) leased by service providers to fulfill customers with service requests, where the edge cloud network consists of both cloudlets in edge networks and remote data centers in the core network. We then design an efficient incentive-compatible mechanism for the problem, and analyze the existence of a Nash equilibrium of the mechanism. Also, we consider an online social welfare maximization problem with uncertain values of customers and without the knowledge of future request arrivals, for which we devise an online learning algorithm by adopting the Multi-Armed Bandits (MAB) method with a bounded regret. We finally evaluate the performance of the proposed mechanisms through simulations and a testbed. Results show that the proposed mechanisms deliver up to 27% higher social welfare than those of existing studies
CONTRIBUTIONS À LA THÉORIE DE MORSE DISCRÈTE ET À L'HOMOLOGIE DE HEEGAARD-FLOER COMBINATOIRE

Cette these porte sur deux aspects de la theorie de Morse: theorie de Morse discrete de Forman (cas de la dimension finie) et homologie de Heegaard-Floer (cas de la dimension infinie). Dans une premiere partie, on s'interesse au probleme de relevement de signe pour l'homologie de Heegaard-Floer combinatoire. On montre que la construction originale faite par Manolescu, Ozsvath, Szabo et D. Thurston peut etre refaite de maniere plus conceptuelle. On donne ensuite le lien entre ces deux constructions puis finalement on decrit un algorithme qui permet de calculer les signes. La seconde partie porte sur la theorie de Morse discrete definie par Forman. Apres avoir fait le lien entre l'algebre sur les complexes de chaines et la theorie de Morse discrete, on montre que le complexe de Thom-Smale donne par une fonction de Morse lisse sur variete lisse close peut etre realise par une triangulation et une fonction de Morse discrete sur celle-ci. On utilise cela pour obtenir une representation particuliere sous forme de couplage complet de toute structure d'Euler sur une variete de dimension 3 close orientee.
Quality assurance of functional biscuits produced from red kidney beans flour

The aim of this work was to produce functional biscuits from wheat flour substituted with different ratios of red bean flour (RBF). Red kidney beans subjected to chemical analysis, vitamins content and antioxidant activity. Red beans flour is a good source of protein, ash and fiber contents than wheat flour, RB consider as a good source of antioxidant activity. The rheological properties of dough samples prepared by using wheat flour substituted with 5, 10, 15 and 20% of RBF were evaluated by both farinograph and extensograph apparatus. It is obvious that by increasing the substitution levels in the blends from 5 to 20% of RBF, the water absorption was increased in all the blends as compared with control sample (100% WF). The addition of RBF in the blends at all ratios led to decrease in the resistance to extension of the dough as compared to the control sample. The quality of biscuits prepared with wheat flour supplemented by red beans flour was investigated. Sensory evaluation show that supplemented of 5, 10 and 15% red beans flour have the best overall acceptability compare with 20% red beans flour. It is evident from the study that acceptable biscuits of improved nutritional value could be produced from whole-wheat flour supplemented with different ratios of RBF. This will increase the use of this locally grown grain while reducing the amount of wheat imported into Egypt.
Social Media As A Marketing Media For Pandansari Mangrove Forest Tourism Object

Facing the industrial revolution 4.0 which makes technology development even more rapid making the world of tourism in Indonesia also progresses. Tourism that is experiencing development certainly provides additional foreign exchange for the country. Brebes Regency as a district that has many hidden tourism treasures is currently one of the regencies in Central Java that is quite reckoned with in the world of tourism. The purpose of this study are to see how much social media impact has in order to enlarge the number of visitors in Pandansari mangrove forest at Kaliwlingi Village Brebes Regency through tourism promotion. The idea of marketing through social media is currently the new prima donna. Social media is used to market tourism objects more broadly. Reaching larger audiences, the work of social media continues to be improved mainly in attracting potential visitors who have never come to this place at all. The analysis object in this paper is the social media account belonging to the Pandansari mangrove forest located in Kaliwlingi Village Brebes Regency which is often referred to as Dewi Mangrovesari. Using descriptive qualitative research technique, it was found that the use of social media as marketing was effective because currently people are very familiar with technology. Good management and efforts to preserve the environment are also one of the things promoted by the Pandansari mangrove forest tourism object.
Effect of lower‐leg trauma and knee arthroscopy on procoagulant phospholipid‐dependent activity

Lower‐leg injury and knee arthroscopy are both associated with venous thromboembolism (VTE). The mechanism of VTE in both situations is unknown, including the role of procoagulant microparticles. This may provide useful information for individualizing thromboprophylactic treatment in both patient groups.
Trees with a unique maximum independent set and their linear properties

Trees with a unique maximum independent set encode the maximum matching structure in every tree. In this work we study some of their linear properties and give two graph operations, stellare and S-coalescence, which allow building all trees with a unique maximum independent set. The null space structure of any tree can be understood in terms of these graph operations.
Ethics Across The Curriculum: An Effective Response To Abet 2000

ABET 2000 challenges the traditional engineering curriculum by putting forward innovative general criteria to which any engineering program must respond. Engineering programs answer the challenge by developing objectives and measurable outcomes that represent locally generated instantiations of these criteria. Rather than elicit self-evaluations that merely tabulate activities designed to respond to surface criteria (bean-counting efforts), ABET obliges engineering schools to develop procedures to assess success in meeting these locally generated objectives and requires that they show that they have implemented a continuous process of self-improvement.
An eco-evo-devo genetic network model of stress response

Abstract The capacity of plants to resist abiotic stresses is of great importance to agricultural, ecological and environmental sustainability, but little is known about its genetic underpinnings. Existing genetic tools can identify individual genetic variants mediating biochemical, physiological, and cellular defenses, but fail to chart an overall genetic atlas behind stress resistance. We view stress response as an eco-evo-devo process by which plants adaptively respond to stress through complex interactions of developmental canalization, phenotypic plasticity, and phenotypic integration. As such, we define and quantify stress response as the developmental change of adaptive traits from stress-free to stress-exposed environments. We integrate composite functional mapping and evolutionary game theory to reconstruct omnigenic, information-flow interaction networks for stress response. Using desert-adapted Euphrates poplar as an example, we infer salt resistance-related genome-wide interactome networks and trace the roadmap of how each SNP acts and interacts with any other possible SNPs to mediate salt resistance. We characterize the previously unknown regulatory mechanisms driving trait variation; i.e. the significance of a SNP may be due to the promotion of positive regulators, whereas the insignificance of a SNP may result from the inhibition of negative regulators. The regulator-regulatee interactions detected are not only experimentally validated by two complementary experiments, but also biologically interpreted by their encoded protein–protein interactions. Our eco-evo-devo model of genetic interactome networks provides an approach to interrogate the genetic architecture of stress response and informs precise gene editing for improving plants’ capacity to live in stress environments.
On Generalizations of the Stirling Number Triangles

Sequences of generalized Stirling numbers of both kinds are introduced. These sequences of triangles (i.e. infinite-dimensional lower triangular matrices) of numbers will be denoted by S2(k;n,m) and S1(k;n,m) with k ∈ Z. The original Stirling number triangles of the second and first kind arise when k = 1. S2(2;n,m) is identical with the unsigned S1(2;n,m) triangle, called S1p(2;n,m), which also represents the triangle of signless Lah numbers. Certain associated number triangles, denoted by s2(k;n,m) and s1(k;n,m), are also defined. Both s2(2;n,m) and s1(2;n + 1,m + 1) form Pascal’s triangle, and s2(−1, n,m) turns out to be Catalan’s triangle. Generating functions are given for the columns of these triangles. Each S2(k) and S1(k) matrix is an example of a Jabotinsky matrix. The generating functions for the rows of these triangular arrays therefore constitute exponential convolution polynomials. The sequences of the row sums of these triangles are also considered. These triangles are related to the problem of obtaining finite transformations from infinitesimal ones generated by x d dx , for k ∈ Z. AMS MSC numbers: 11B37, 11B68, 11B83, 11C08, 15A36 1 Overview Stirling’s numbers of the second kind (also called subset numbers), and denoted by S2(n,m) (or {
Monocytes, non-alcoholic liver disease crosstalk

With the increasing prevalence of the obesity epidemic, non-alcoholic fatty liver disease (NAFLD) represent the most common liver disease worldwide and one of the important causes of hepatocellular carcinoma development. Also, it is strongly associated with type 2 diabetes mellitus. Metabolic inflammation has been suggested to play a central role in NAFLD progression. Monocytes represent a key player in meta-inflammation. Circulating monocytes, adipose tissue macrophages (ATM), and liver resident macrophages have roles in NAFLD development and progression. Adipose tissue macrophages accumulate as a result of adipose tissue hypoxia, they produce huge amount of cytokines inducing insulin resistance and excess fat accumulation in the liver. In this review, we highlight the burden of NAFLD, its association to metabolic parameters and obesity, with illustration of obesity induced inflammation and pathogenic pathways involved in insulin resistance development. We pointed to the plasticity of circulating monocytes, phenotypic and functional alteration of their subsets in NAFLD, and the therapeutic approaches targeting macrophages and their effects on improvement of insulin resistance and NAFLD progression.
Magnesium Sulphate, Lidocaine or Nitroglycerin for Controlled Hypotension and Quality of the Surgical Field in Patients Undergoing Tympanoplasty

Background: Intraoperative bleeding impairs surgical field visibility during tympanoplasty; several methods have been used to decrease blood loss and improve the quality of the surgical field, one of them is usage of hypotensive anesthetic agents. Objective: This study aimed to compare the effect of magnesium sulphate, lidocaine or nitroglycerin for controlled hypotension on hemodynamics, quality of the surgical field and blood loss in patients undergoing tympanoplasty. Patients and methods: A prospective double blind randomized clinical study included 45 patients of both genders, ASA I&II undergoing tympanoplasty were allocated into Three groups ( 15 patients each ) group (M) received magnesium sulphate by giving loading dose 40 mg/kg then the maintenance dose 15 mg/kg/hr, group (L) received lidocaine by giving an infusion dose of 2 mg/kg/hr and group (N) received nitroglycerin by giving an infusion dose of 5-10 μg/kg/min. For each group ( mean arterial blood pressure "MABP", heart rate "HR", quality of the surgical field, total IV fluids given, total blood loss, intraoperative complications, duration of the surgery and the extubation time) were recorded. Results: The studied doses of the drugs achieved the target mean arterial pressure (50–65 mmHg) with superior hemodynamic stability in the lidocaine group. Group L showed a statistically significant decrease in blood loss (p<0.05) , a statistically significant better quality of the surgical field (p<0.05) and a statistically significant less complications (p<0.05) compared to the other studied groups. Conclusion: It was showed that using any of these three drugs can be effective for controlled hypotension in patients undergoing tympanoplasty but lidocaine has the priority for the achieving stablility of the hemodynamics, the best quality of the surgical field and the least blood loss.
Genetics of corneal endothelial dystrophies

The corneal endothelium maintains the level of hydration in the cornea. Dysfunction of the endothelium results in excess accumulation of water in the corneal stroma, leading to swelling of the stroma and loss of transparency. There are four different corneal endothelial dystrophies that are hereditary, progressive, non-inflammatory disorders involving dysfunction of the corneal endothelium. Each of the endothelial dystrophies is genetically heterogeneous with different modes of transmission and/or different genes involved in each subtype. Genes responsible for disease have been identified for only a subset of corneal endothelial dystrophies. Knowledge of genes involved and their function in the corneal endothelium can aid understanding the pathogenesis of the disorder as well as reveal pathways that are important for normal functioning of the endothelium. [Kannabiran C. 2009 Genetics of corneal endothelial dystrophies. J. Genet. 88, 487–494]
Une Table d'Association d'Intervalles Fusionnable

This article describes an efficient persistent mergeable data structure for map- ping intervals to values. We call this data structure rangemap. We provide an example of appli- cation where the need for such a data structure arises (abstract interpretation of programs with pointer casts). We detail different solutions we have considered and dismissed before reaching the solution of rangemaps. We show how they solve the initial problem. We then describe their implementation and, as a conclusion, mention further work we would like to do. RESUME. Cet article decrit une structure de donnees representant efficacement des tables d'associations persistantes indexees par des intervalles, ayant la propriete supplementaire d'etre fusionnable. Nous nommons (en anglais) rangemap cette structure de donnees. Nous donnons un exemple de circonstances dans lesquelles se rencontre le besoin d'associer de cette facon des valeurs a des intervalles (analyse par interpretation abstraite de programmes com- portant des conversions de pointeurs). Nous detaillons differentes solutions envisagees puis ecartees avant d'arriver a la solution des rangemaps. Nous montrons ensuite comment ceux-ci resolvent le probleme initial. Enfin, nous decrivons leur implementation avant d'evoquer les travaux en cours et futurs que nous nous proposons de mener a ce sujet.
Portal Histamine inhibits the production of interleukin-12 through interaction with H 2 receptors

IL-12 is essential for T helper 1 (Th1) development and inhibits the induction of Th2 responses. Atopic diseases, which are characterized by Th2 responses, are associated with the overproduction of histamine. Here we present evidence that histamine, at physiological concentrations, strongly inhibits human IL-12 p40 and p70 mRNA and protein production by human monocytes. The use of specific histamine receptor antagonists reveals that this inhibition is mediated via the H 2 receptor and induction of intracellular cAMP. The inhibition of IL-12 production is independent of IL-10 and IFNg . The observation that histamine strongly reduces the production of the Th1-inducing cytokine IL-12 implies a positive feedback mechanism for the development of Th2 responses in atopic patients. ( J. Clin. Invest. 1998. 102:1866–1873.)
OP-ICBJ210035 1..9

*Department of Integrative Biology, University of Texas, Austin, TX 78712, USA; Neuroscience Center, Louisiana State University School of Medicine, 2020 Gravier Street, New Orleans, LA 70112, USA; Department of Cell Biology and Anatomy, Louisiana State University School of Medicine, New Orleans, LA 70112, USA; Department of Ophthalmology, Louisiana State University School of Medicine, New Orleans, LA 70112, USA; Department of Otorhinolaryngology, Louisiana State University School of Medicine, New Orleans, LA 70112, USA
University of New Hampshire Scholars' Repository University of New Hampshire Scholars' Repository

Reinforcement learning (RL) techniques have been applied to smart grids with a variety of applications. The most common objective is to optimize profit for one actor in the system. The goal of this work is to apply different RL models to the smart grid at the Shoals Marine Laboratory (SML) located on Appledore Island, Maine in an effort to reduce costs and minimize the amount of nonrenewable energy consumed on the island. The RL models implemented resulted in more sustainable practices in simulations, with a linear spline model outperforming the naive policy the SML currently uses. Future work includes extending the RL model and more validation testing outside of the simulation.