Miracle-dz/UniFAR-FTUs huggingface dataset:
Cumulative Emissions of CO2 for Electric and Combustion Cars: A Case Study on Specific Models

This work includes calculations of the cumulative CO2 emissions of two comparable cars—the VW Golf VII—one with a combustion engine and the other with an electric motor. Calculation of CO2 emissions was performed, taking into account the stages of production, utilization and use of the above-mentioned vehicles. For the use phase, it was assumed that the total mileage of the car will be 150,000 km over 10 years. For the electric vehicle, calculations were made assuming five different sources of electricity (from coal only, from natural gas only, from PV and wind turbines, an average mix of European power sources and an average mix of Polish power sources; W1–W5 designations, respectively). For individual sources of electricity, cumulative CO2 emissions were taken into account, that is, resulting both from the production of electricity and the use of the resources (for example, technical service per 1 kWh of electricity produced). The obtained results of the analysis show that for the adopted assumptions regarding operation, for variants W2–W5, the use of an electric car results in lower cumulative CO2 emission than a the use of a combustion car. For a combustion car, the value was 37,000 kg-CO2, and for an electric car, depending on the variant, the value was 43, 31, 16, 23 and 34 thousand kg-CO2 for variants W1 to W5, respectively. Based on the emissions results obtained for individual stages of the use of selected vehicles, a comparative analysis of cumulative CO2 emissions was performed. The purpose of this analysis was to determine whether the replacement of an existing combustion car (that has already been manufactured; therefore, this part of the analysis does not include CO2 emissions in the production stage) with a new electric car, which has to be manufactured, therefore associated with additional CO2 emissions, would reduce cumulative CO2 emissions. Considering three adopted average annual car mileages (3000, 7500 and 15,000 km) and the previously described power options (W1–W5), we sought an answer as to whether the use of a new electric car would be burdened with lower cumulative CO2 emissions. In this case we assumed an analysis time of 15 years. For the worst variant from the point of view of CO2 emissions (W1, electricity from coal power sources only), further use of a combustion car is associated with lower cumulative CO2 emissions than the purchase of a new electric car over the entire analyzed period of 15 years. In turn, for the most advantageous variant (W3, electricity from PV or wind power sources) with an annual mileage of 3000 km, the purchase of a new electric car results in higher cumulative CO2 emissions throughout the analyzed period, whereas for an annual milage of 7500 or 15,000 km, replacing the car with an electric car “pays back” in terms of cumulative CO2 emissions after 8.5 or 4 years, respectively.
Prehistoric spread rates and genetic clines

The seminal book The Neolithic transition and the genetics of populations in Europe by Ammerman and Cavalli-Sforza (1984) contains the analysis of archaeological data that led to the result that the spread rate of the Neolithic in Europe was on average about 1 km/yr. It also contains the direct application of a mathematical model that provides an explanation for this value (1 km/yr), the so-called 'wave-of-advance model'. The book also reviews work on the possibility that genetic clines were formed due to the spread of the Neolithic in Europe. This paper is a review of work on both topics since their first joint paper, which was published 50 years ago (Ammerman and Cavalli-Sforza 1971). We also discuss the importance of these and related contributions by Cavalli-Sforza, the present state of the art, and possible lines of future progress. Based on "Ammerman AJ, Cavalli-Sforza LL. The Neolithic transition and the genetics of populations in Europe. New Jersey: Princeton University Press. 1984”.
The ethnic wage penalty in Western European regions: Is the European integration model confirmed when differences within countries are considered?

BACKGROUND The European model of integration of recent immigrants is characterised by a trade-off between employment and job quality, which takes different forms in Southern and Continental Europe. In Mediterranean countries, migrants have similar employment opportunities as natives, but they have high risks of entering the lowest strata of the occupational structure. In Continental Europe the trade-off is reversed: Migrants have lower employment opportunities, but once employed, they face a lower penalisation in terms of job quality than the one faced by immigrants living in Southern Europe. This work focuses on the regional heterogeneity of the model of inclusion of recent immigrants in the European labour markets, analysing how migrant–native gaps in wages and in the probability of (dependent) employment change across areas of the same country. Is the trade-off between employment and job quality confirmed when regional differences are considered? Are there gender differences in the models of inclusion?
High-Detail Fault Segmentation: Deep Insight into the Anatomy of the 1983 Borah Peak Earthquake Rupture Zone (Mw 6.9, Idaho, USA)

Following observations made in a survey campaign along the Lost River Fault (Idaho, USA) in 2019, we integrate both original and previously published data to obtain a detailed segmentation of the fault sections that failed in the 1983 Borah Peak earthquake (Mw 6.9). The earthquake ruptured the topographic surface with an oblique-normal faulting mechanism, activating two SW-dipping fault segments (Thousand Springs and Warm Springs) and a branching SSW-dipping fault (Arentson Gulch Fault) and producing coseismic surface ruptures with up to 3 m of vertical separation. We augment the 1983 earthquake description by interpreting high-resolution topography and fault mapping. We use quality vertical separation data, rupture zone width measurements, and fault slip data to analyze major and minor structural-geometric complexities, highlighting a partition of the deformation and a fault segmentation into four detail levels (i.e., segments, sections, subsections, and sectors). Our work provides new details of the 1983 Borah Peak earthquake, constraints for paleoseismic and seismotectonic studies, and a methodological approach applicable in other areas of the world. Our fault-slip data show variations along fault-strike that we interpret as kinematic partitioning. In 1983, the main southern segment had a large rupture zone width, while the northern segment localized the deformation. The distributed ruptures accommodate a large portion of the rupture length (~19.5 km versus 31 km for the main rupture) and displacement (~66%). 83% of the surface faulting and 80% of the displacement are located at the hanging wall of the main rupture. There is a strong correlation between vertical separation, rupture zone width, rupture position (footwall or hanging wall), and fault geometry. We highlight the control of the obliquity and kinematic partitioning in the surface expression of the earthquake propagation. We interpret the coseismic (i.e., 1983) and long-term (i.e., Quaternary) behavior, showing that the two activated segments had similar cumulated behaviors in distributing the deformation between synthetic and antithetic ruptures, despite the different geometries. Our results have implications for fault rupture behavior with application to rupture hazard.
Proteomic Analysis of the Role of the Adenylyl Cyclase–cAMP Pathway in Red Blood Cell Mechanical Responses

Red blood cell (RBC) deformability is modulated by the phosphorylation status of the cytoskeletal proteins that regulate the interactions of integral transmembrane complexes. Proteomic studies have revealed that receptor-related signaling molecules and regulatory proteins involved in signaling cascades are present in RBCs. In this study, we investigated the roles of the cAMP signaling mechanism in modulating shear-induced RBC deformability and examined changes in the phosphorylation of the RBC proteome. We implemented the inhibitors of adenylyl cyclase (SQ22536), protein kinase A (H89), and phosphodiesterase (PDE) (pentoxifylline) to whole blood samples, applied 5 Pa shear stress (SS) for 300 s with a capillary tubing system, and evaluated RBC deformability using a LORRCA MaxSis. The inhibition of signaling molecules significantly deteriorated shear-induced RBC deformability (p < 0.05). Capillary SS slightly increased the phosphorylation of RBC cytoskeletal proteins. Tyrosine phosphorylation was significantly elevated by the modulation of the cAMP/PKA pathway (p < 0.05), while serine phosphorylation significantly decreased as a result of the inhibition of PDE (p < 0.05). AC is the core element of this signaling pathway, and PDE works as a negative feedback mechanism that could have potential roles in SS-induced RBC deformability. The cAMP/PKA pathway could regulate RBC deformability during capillary transit by triggering significant alterations in the phosphorylation state of RBCs.
Acoustic Design Criteria in Naturally Ventilated Residential Buildings: New Research Perspectives by Applying the Indoor Soundscape Approach

The indoor-outdoor connection provided by ventilation openings has been so far a limiting factor in the use of natural ventilation (NV), due to the apparent conflict between ventilation needs and the intrusion of external noise. This limiting factor impedes naturally ventilated buildings meeting the acoustic criteria set by standards and rating protocols, which are reviewed in this paper for residential buildings. The criteria reflect a general effort to minimize noise annoyance by reducing indoor sound levels, typically without a distinction based on a ventilation strategy. Research has developed a number of solutions, discussed here, that try to guarantee ventilation without compromising façade noise insulation, but, currently, none have been adopted on a large scale. This concept paper highlights the main limits of the current approach. First, a fragmented view towards indoor environmental quality has not included consideration of the following acoustic criteria: (i) how buildings are designed and operated to meet multiple needs other than acoustical ones (e.g., ventilation, visual, and cooling needs) and (ii) how people respond to multiple simultaneous environmental factors. Secondly, the lack of a perceptual perspective has led acoustic criteria to neglect the multiple cognitive and behavioral factors impinging on comfort in naturally ventilated houses. Indeed, factors such as the connection with the outside and the sense of control over one’s environment may induce “adaptive acoustic comfort” opportunities that are worth investigating. The mere use of different sound level limits would not be enough to define criteria tailored to the complex user–building interaction that occurs under NV conditions. More holistic and human-centered approaches are required to guarantee not only neutrally but even positively perceived indoor acoustic environments. For this reason, this paper considers this apparent conflict from a soundscape viewpoint, in order to expose still unexplored lines of research. By underpinning a perceptual perspective and by contextualizing it, the indoor soundscape approach provides a framework capable of overcoming the limits of the traditional noise control approach. This could provide the opportunity to foster a wider adoption of NV as a passive design strategy that enhances user health and well-being, while enabling low-cost, and low-energy cooling and ventilation, thereby contributing to current climate change challenges.
Investigation of Different Geometric Representations of Road User Volume and Their Impact on Postencroachment Time

Surrogate safety analysis refers to a large class of methods to evaluate safety at any site without waiting for collisions. A core requirement of any safety analysis method is the calculation of reliable safety indicators, which are mostly computed at a given time with the use of the positions and speeds of the two interacting road users. These positional data can be obtained automatically with video sensors and computer vision techniques. Therefore, automated safety analysis based on video data has gained the interest of safety analysts. However, automatic, video-based methods for surrogate safety analysis generally consider road users as points. Hence, the geometric representation of the road user volume (the outline) can affect the accuracy of the calculated indicators and consequently the safety evaluation. This study investigated geometric representations of road users for the automated computation of safety indicators. In particular, they were compared in the measurement of postencroachment time. This investigation relied on a real-world case study at two sites with two camera configurations, the first with an almost overhead view and the second with a much lower camera angle, which was more common in practice. The results show that representing the road user as a convex hull with extracted features is most accurate, with a root mean square error equal to 0.25 s for computation at the first site with an overhead view. With a lower camera angle, the advantage of that method disappeared and a simpler circular representation with a fixed radius showed the best results.
Conversion of Hyperpolarized [1-13C]Pyruvate in Breast Cancer Cells Depends on Their Malignancy, Metabolic Program and Nutrient Microenvironment

Simple Summary The metabolic phenotype of cancer cells depends on their metabolic program and the availability of nutrients in the tumor microenvironment. Metabolic activities in vivo can be characterized by using magnetic resonance spectroscopy (MRS) for analyzing the conversion of hyperpolarized 13C-pyruvate to 13C-lactate. To investigate how the conversion rates (kpl) of exogenous pyruvate to lactate are affected by glucose and glutamine availability, two breast cancer cell lines of different malignancy were analyzed in vitro for the Warburg effect, enzyme activities, and flux of 13C-glucose-derived metabolites. Conversion of 13C-pyruvate correlated with glucose/glutamine-dependent glycolytic activity, but not with the Warburg effect. Unexpectedly, the more malignant cells had lower kpl-values, in spite of having higher lactate production. It is suggested that exogenous pyruvate is converted by LDH associated with the glycolytic micro-compartment. Analyses of pyruvate-to-lactate conversion with MRS thus depend on both the metabolic program and the nutritional state of the tumors. Abstract Hyperpolarized magnetic resonance spectroscopy (MRS) is a technology for characterizing tumors in vivo based on their metabolic activities. The conversion rates (kpl) of hyperpolarized [1-13C]pyruvate to [1-13C]lactate depend on monocarboxylate transporters (MCT) and lactate dehydrogenase (LDH); these are also indicators of tumor malignancy. An unresolved issue is how glucose and glutamine availability in the tumor microenvironment affects metabolic characteristics of the cancer and how this relates to kpl-values. Two breast cancer cells of different malignancy (MCF-7, MDA-MB-231) were cultured in media containing defined combinations of low glucose (1 mM; 2.5 mM) and glutamine (0.1 mM; 1 mM) and analyzed for pyruvate uptake, intracellular metabolite levels, LDH and pyruvate kinase activities, and 13C6-glucose-derived metabolomics. The results show variability of kpl with the different glucose/glutamine conditions, congruent with glycolytic activity, but not with LDH activity or the Warburg effect; this suggests metabolic compartmentation. Remarkably, kpl-values were almost two-fold higher in MCF-7 than in the more malignant MDA-MB-231 cells, the latter showing a higher flux of 13C-glucose-derived pyruvate to the TCA-cycle metabolites 13C2-citrate and 13C3-malate, i.e., pyruvate decarboxylation and carboxylation, respectively. Thus, MRS with hyperpolarized [1-13C-pyruvate] is sensitive to both the metabolic program and the nutritional state of cancer cells.
Neuroendocrine Neoplasms of the Gynecologic Tract

Simple Summary Neuroendocrine refers to the cells that synthesize and secrete messenger chemicals such as neuropeptides and amines. Neuroendocrine neoplasms (NENs) are aggressive tumors arising from neuroendocrine cells, with an annual incidence of 6.98/100,000 and a prevalence of 170,000 in the United States. Primary gynecologic NENs constitute ≤2% of female reproductive tumors. NENs of the gynecologic tract are associated with high recurrence rates and dismal prognosis, making their treatment challenging. This article focuses on the updated staging classifications, clinicopathological characteristics, imaging, and management of NENs of the gynecological tract. Abstract Gynecological tract neuroendocrine neoplasms (NEN) are rare, aggressive tumors from endocrine cells derived from the neuroectoderm, neural crest, and endoderm. The primary gynecologic NENs constitute 2% of gynecologic malignancies, and the cervix is the most common site of NEN in the gynecologic tract. The updated WHO classification of gynecologic NEN is based on the Ki-67 index, mitotic index, and tumor characteristics such as necrosis, and brings more uniformity in the terminology of NENs like other disease sites. Imaging plays a crucial role in the staging, triaging, restaging, and surveillance of NENs. The expression of the somatostatin receptors on the surface of neuroendocrine cells forms the basis of increasing evaluation with functional imaging modalities using traditional and new tracers, including 68Ga-DOTA-Somatostatin Analog-PET/CT. Management of NENs involves a multidisciplinary approach. New targeted therapies could improve the paradigm of care for these rare malignancies. This article focuses on the updated staging classifications, clinicopathological characteristics, imaging, and management of gynecologic NENs of the cervix, ovary, endometrium, vagina, and vulva, emphasizing the relatively common cervical neuroendocrine carcinomas among these entities.
A Function Spaces Model to Express the Development Trend of Electronic information manufacturing Industry in Zhejiang Province During 1978-2013

Since the reform and opening up to the outside world, vigorous development of electronic-information-manufacturing industry in Zhejiang Province has become the pillar industry and leading industry of Zhejiang Province. Based on the statistical analysis of the manufacturing industry of electronic information industry in Zhejiang province from 1978 to 2013, the corresponding numerical function space model and the comparison function space model are established. To further promote the Zhejiang Province Electronic Information Industry Development of the manufacturing industry, Zhejiang Province. should start from the following three aspects: first, attach importance to technological innovation of information industry. Second, speed up the information industry cluster. Third, promote the internationalization of information industry.
In Their Experience: A Review of Racial and Sexual Minority Experience in Academe and Proposals for Building an Inclusive Criminology

Feminist criminologists were pioneers in highlighting that academics’ standpoints (i.e., their social and societal positionalities) influence which “objective” truth they tell. Testimonies, the sharing of one's story, can provide important angles to our understandings of social phenomenon, including of life in the academic sphere. In the present work, we introduce our conceptualization of “inclusive criminology” as a framework for integrating criminological inquiry into a cohesive whole which asserts societies’ rights to valid and complete knowledge as requiring inclusion of previously marginalized identities. In response to this requisite, we conduct a review of published testimonial narratives within criminology and criminal justice (CCJ) as well as a sample of works from other social sciences to inform recommendations on how to meet this inclusive aim.
The Effect of Multiple Sclerosis (MS) on Central Nervous System (CNS)

Multiple sclerosis (MS) is an autoimmune disorder of the CNS in which myelin components are specifically targeted by the immune system and lead to the destruction of myelin axons and associated debilitating symptoms [1-3]. Also, according to studies, no effective treatment for this disease has been found. Therefore, a safe and effective treatment option for MS is needed. Also, the central nervous system (CNS) is separated from the immune system by a blood-brain barrier and is traditionally considered “immune system protection”, and immune cells are also able to target the brain and lead to CNS autoimmune disorders Pahan et al. [4]. An article measuring the effects of cinnamon on MS mice used cinnamon and the brown bark of the cinnamon tree, which has been used as a spice or flavoring around the world for centuries. In addition, medieval physicians used cinnamon for medical purposes to treat a variety of disorders such as osteoarthritis, cough, hoarseness, sore throat, etc. Also, according to the findings of various articles, the results show that widespread inflammation, Loss of regulatory T cells (Tregs), autoimmune Th1 and Th17 cell hyperactivity, failure of the cerebral blood-brain barrier (BBB) and blood-spinal cord barrier (BSB), and loss of light-protective molecules in the CNS are some of the symptoms that Demystifying manifestations are required in MS [1-3]. Interestingly, NaB treatment is able to inhibit the expression of proinflammatory molecules in cultured astrocytes and microglia [4]. Reversal of NaB by inhibiting NF-κB activation and expression of nitric oxide synthase (iNOS) by mevalonate, 3-hydroxy-3methylglutaryl-coenzyme A and farnesyl pyrophosphate, mediators of the mevalonate pathway, in active astrocytes suggests that NaB. It has an inflammatory effect by inhibiting the cholesterolbiosynthesis pathway However, although NaB is able to lower cholesterol levels, cholesterol has no role in inhibiting NaBmediated iNOS [4]. Also, in an article by Brahmachari et al. [4], they measured the effects of cinnamon on mice with MS in which NaB reduced NF-κB activation and iNOS expression in glial cells by reducing p21ras activation, according to which oral administration of cinnamon powder [5] and drinking water containing NaB metabolite [4] suppresses iNOS and IL-1β expression in vivo in the spinal cord and cerebellum of EAE mice, these findings suggest that cinnamon is able to reduce in vivo inflammation in rat CNS EAE is also another feature of neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), cinnamon and NaB. It also improves hippocampal function in an animal model of AD [6] and from nigrostriatum. Animal model PD Protects [7].
The Origins and Consequences of Racialized Schemas about U.S. Parties

Abstract Two parallel processes structure American politics in the current moment: partisan polarization and the increasing linkage between racial attitudes and issue preferences of all sorts. We develop a novel theory that roots these two trends in historical changes in party coalitions. Changing racial compositions of the two major parties led to the formation of racialized images about Democrats and Republicans in people’s minds—and these images now structure Americans’ partisan loyalties and policy preferences. We test this theory in three empirical studies. First, using the American National Election Studies we trace the growing racial gap in party coalitions as well as the increasing overlap between racial and partisan affect. Then, in two original survey studies we directly measure race–party schemas and explore their political consequences. We demonstrate that race–party schemas are linked to partisan affect and issue preferences—with clear implications for the recent developments in U.S. politics.