Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk of Major Bleeding and Thromboembolism in Asian Atrial Fibrillation Patients Using Non-vitamin K Oral Anticoagulants Versus Warfarin

Background: Bleeding or thromboembolism prevention is important in patients with atrial ﬁ brillation receiving anticoagulants, including non-vitamin K oral anticoagulants and warfarin. Asians have higher risks of bleeding complications when taking anticoagulants. However, evidence that considers laboratory parameters is lacking. Objective: We aimed to compare the safety and effectiveness between non-vitamin K oral anticoagulants and warfarin in Asian patients with atrial ﬁ brillation. Setting: Retrospective design using hospital-based data. Method: This propensity score-matched cohort study included data extracted from the electronic medical records of the En Chu Kong Hospital Research Database. Main outcome measure: Outcome measures were major bleeding and thromboembolism. Cox proportional hazard models were applied for evaluating hazard ratios with 95% con�dence intervals. Results: Among 1,075 patients with atrial ﬁ brillation, 687 and 388 were administered non-vitamin K oral anticoagulants and warfarin, respectively. After propensity score matching, 264 patient pairs were selected. Compared with warfarin use, non-vitamin K oral anticoagulant use was associated with similar risks for major bleeding and thromboembolism; however, the latter was associated with increased gastrointestinal bleeding risks (adjusted hazard ratio 3.59; 95% con�dence interval, 1.31-11.39). Notably, an approximately 10-fold increased risk of gastrointestinal bleeding was observed in 0-6-month non-vitamin K oral anticoagulant users (adjusted hazard ratio 10.13, 95% con�dence interval 1.27-80.89). Conclusion: Non-vitamin K oral anticoagulant use was not associated with major bleeding and thromboembolism occurrence in Asian patients with atrial ﬁ brillation. However, non-vitamin K oral anticoagulant use was associated with increased gastrointestinal bleeding risks, especially when used within 0-6 months. NOAC usage rate and TTR during warfarin treatment were 91.9% and 32% in our analysis using real-world data. The use of both anticoagulants may be associated with low e�cacy or negative consequences. We suggest a time-varied re-evaluation of the bene�ts and risks for anticoagulants in Asian patients with AF based on their baseline probability for developing dangerous blood clots. Future studies evaluating the optimal dosing and TTR still need to be conducted in Asian patients with AF.
Ethical Practices of Registrars al Practices of Registrars for an Enhanced Code of Conduct an Enhanced Code of

Ethical conduct is an important ingredient in the leadership educational institution. need for a humanistic approach in administrations is alongsidesuch undertaking. and insights to enhance an existing code of conduct for registrars. experienceasked to reflect on their experiences and highlight important aspects affectdiscipline and mutual respect emerged as important standards that guided their administrative careers. These virtues are transactions also emerged as an important feature. By leading the way, registrars can positively influence the workplace and the academic community. the study led to the development of an enhanced registrars and can be used well. Abstract Ethical conduct is an important ingredient in the leadership educational institution. Since schools are considered need for a humanistic approach in administrations is alongside. Registrars, as educational leaders, should take an active role in such undertaking. This exploratory research aimed to elicit b and insights to enhance an existing code of conduct for registrars. experienced local and foreign registrars were purposefully selected and asked to reflect on their experiences and highlight important aspects affecting ethical practice. Values such as honesty, integrity, teamwork, discipline and mutual respect emerged as important standards that guided their administrative careers. These virtues are transactions of their respective department. Subsequently also emerged as an important feature. By leading the way, registrars can positively influence the workplace and the academic community. the study led to the development of an enhanced registrars and can be used as benchmark material for other professions as well.
Emotional Intelligence of Higher Secondary School Students With Respect to Their Gender

Present Study lights on Emotional Intelligence in higher secondary school students. Emotional intelligence is the ability to understand emotional intelligence and their causes, the capability to effectively regulate these emotions in one self and in others and most importantly being able to use the emotions as a source of and dealing with social situations. The sample of present study was drawn randomly from different higher secondary schools, of baramulla district state Jammu and Kashmir. The researcher therefore selected 11th & 12th grade 120 students randomly from different higher secondary schools of baramulla district, out of 120 students 60 were girls and 60 were boys. The investigator has employed English version of Emotional Intelligence scale (EIS) as developed by Anukool Hyde, Sanjyot Pethe And Upinder Dhar is used for the present study. The scale is based on five dimensions viz. self awareness, empathy, self motivation, emotional stability, managing relations, integrity, self development, value orientation, commitment, altruistic behavior. There is significant difference between boys and girls in the level of emotional intelligence. compliance patterns of and intelligence and academic achievement of high school
ERP VALUE: THE MARKET RESPONSE TO ANNOUNCEMENTS OF ENTERPRISE RESOURCE PLANNING INVESTMENTS

This paper evaluates the change in a firm’s equity value as a result of the firm announcing that it plans to integrate its operations with an enterprise resource planning (ERP) system, or a module of an ERP system. Investments in Information Systems (IS) are increasing as firms strive to optimize their business processes, and have become one of the largest categories of capital expenditures of U.S. businesses. There is a growing body of research based on evaluating the effects of such IT investments and their contribution to firm value. Using an event study approach, the event being the public announcement of ERP investment, and the measure being the change in stock price, we evaluate if ERP investments increase value for firms. Based on a sample of 89 firms publicly traded in U.S. stock markets during the period between 1999 and 2008, we conclude that ERP investments create an average of . 81% (α significance = 0.05) incremental value for firms. We consider typical ERP component systems, and observe that supply chain management (SCM) systems are not rewarded with higher abnormal returns than non-SCM, but observe abnormally high amounts of positive compared to negative returns (normal asymmetry sign test, α = 0.01). We examine ERP investments from well known vendors with established reputations in the market, and find that contract announcements with such vendors enjoy abnormal stock market returns of 1.40% (α = 0.01). We then look at firm function, and find that although manufacturing firms gain value (α = 0.05), that non-manufacturing firms do as well (α = 0.10). We evaluate firm size and financial health as attributes that contribute to ERP value and find that both large firms as well as financially healthy firms are rewarded incremental value by the market (α = 0.01). We also consider time period, and find that firms that engaged in post-2005 ERP investments gain significantly more than pre-2005 investments (α = 0.01). Finally, we consider firm and ERP system attributes as independent variables that may contribute to increased firm value as the dependent variable. The paper concludes with discussion about various considerations regarding the potential value created by ERP investments.
Optimisation as a Process for Managing River Ecosystems

Optimisation can assist in the management of riverine ecosystems through the exploration of multiple alternative management strategies, and the evaluation of trade-offs between conflicting objectives. In addition, it can facilitate communication and learning about the system. However, the effectiveness of optimisation in aiding decision making for ecological management is currently limited by four major challenges: identification and quantification of ecosystem objectives; representation of ecosystems in predictive simulation models; specification of objectives and management alternatives in an optimisation framework; and evaluation of model results against actual ecological outcomes. This study evaluates previous literature in ecology, optimisation and decision science, and provides a strategy for addressing the challenges identified. It highlights the need for better recognition and analysis of assumptions in optimisation modelling as part of a process that generates and shares knowledge.
Experimental evaluation of model predictive current control for a modified three-level four-leg indirect matrix converter

This study presents an experimental validation and robustness evaluation of predictive current control and reactive power minimisation strategy for a three-level three-phase four-wire indirect matrix converter. The proposed topology features a unification of conventional four-leg indirect matrix converter with an additional four switches circuit resembling a back-to-back buck circuit to synthesise multi-level variable dual dc-link voltage. A systematic rectifier switching strategy is elaborated to ensure positive fictitious dc-link voltage at any instant. The proposed control and topology have been tested under various transient and steady-state conditions for comprehensive robustness evaluation. The experimental results reveal an outstanding independent load current reference tracking with low ripple current and the reactive power minimisation has been achieved by tuning the weighting factor. The load current tracking and reactive power minimisation have been achieved by properly tuning the weighting factor. The load current harmonics distortion is recorded <;5% during normal operating conditions.
d 1 Recognizing H-2D Ly-49P Activates NK-Mediated Lysis by

Little is known regarding the ligand speciﬁcity of Ly-49 activating receptor subfamily members expressed by NK cells. A new Ly-49 activating receptor related to Ly-49A in its extracellular domain, designated Ly-49P, was recently cloned from 129 strain mice. We independently cloned an apparent allele of Ly-49P expressed by nonobese diabetic and nonobese diabetes-resistant mouse strain NK cells. We found it to be reactive with the A1 Ab thought to recognize a polymorphic epitope expressed only by the Ly-49A inhibitory receptor of the C57BL/6 strain. Rat RNK-16 cells transfected with Ly-49P mediated reverse Ab-dependent cellular cytotoxicity of FcR-positive target cells, indicating that Ly-49P can activate NK-mediated lysis. We determined that RNK-16 lysis of Con A blasts induced by Ly-49P was MHC dependent, resulting in efﬁcient lysis of H-2D d -bearing targets. We found that the D d a 1/ a 2 domain is required for Ly-49P-mediated RNK-16 activation, as determined by exon shufﬂing and transfection. Thus, Ly-49P is the second activating Ly-49 receptor demonstrated to induce NK cytotoxicity by recognizing a class I MHC molecule. The Journal of Immunology, 2000, 165: 1771–1781. additional Ly-49s, designated J, L, M, identiﬁed in the C57BL/6 (B6) genome (25). In addition, two Ly-49 cDNAs, one encoding an inhibitory receptor designated Ly-49O and another encoding an apparent activating receptor designated Ly-49P, were recently cloned from the 129 mouse strain (26). The Ly-49P receptor is closely related to Ly-49A in its carbohydrate recognition domain (CRD), associates with DAP12, and triggers transmembrane signaling (26). These results suggest that Ly-49P may serve as an activating receptor. In this report we de-scribe the independent cloning of Ly-49P from nonobese diabetic (NOD) and nonobese diabetes-resistant (NOR) NK cells and provide evidence that it can activate NK cell cytolytic activity by recognizing H-2D d . Before this report, Ly-49D was the only activating member of the Ly-49 family shown to recognize a class I MHC molecule. Thus, Ly-49P joins Ly-49D in this capability. Understanding the diversity, ligand speciﬁcity, activation potential, and expression of activating Ly-49 members may provide in-sight toward understanding their function(s).
Fatigue behavior of mechanical structures welded with different filler metal

This paper describes an investigation on the effect of using three different filler metals on fatigue behavior of mechanical structures welded. The welding is carried out on the steel A510AP used for the manufacture of gas cisterns and pipes. The welding process used is manual welding with coated electrodes and automatic arc welding. Compact tension CT50 specimen has been used. The three zones of welded joint; filler metal FM, heat affected zone HAZ and base metal BM have been investigated. The results show that the crack growth rate CGR is decreasing respectively in BM, FM and HAZ; however, this variation decreases when stress intensity factor SIF increases. For low values of SIF, the CGR is inferior in the over-matched filler metal of which the value of mismatch M is near unity, but for high values of M the CGR is superior, and the effect of the over-matching on CGR becomes negative. No deviation of the crack growth path has been noticed.
Nonsurgical Approach to Isolated Pancreatic Metastatic Malignant Melanoma: A Case Report and Review of the Literature

Isolated pancreatic metastases from melanoma are rare with high mortality rate and account for less than 1% of metastatic melanomas. Treatment options are limited with highest overall survival reported in those with complete surgical resection. Of cases reported in the literature with nonsurgical management, highest length of survival was reported to be 10 months. We report a case of malignant melanoma with isolated pancreatic metastasis treated with interferon therapy and immunotherapy, with evidence of progressive tumor shrinkage and survival at 38 months.
Social Reactions to Disclosure of Sexual Violence in Adulthood and Women’s Sexuality: The Mediating Role of Shame and Guilt

Abstract This study examined the mediating role of emotions related to sexual violence in adulthood in the associations between social reactions to sexual violence disclosure and sexual outcomes. Self-reported data were collected from 324 women reporting sexual violence and path analyses were conducted among the 264 women (81.5%) who disclosed their most recent sexual violence experience. Results showed that emotional support was associated with higher sexual satisfaction. Victim blame was associated with greater guilt related to the sexual violence, which, in turn, was associated with higher sexual compulsivity. Stigmatization was associated with greater shame related to the sexual violence, which, in turn, was associated with higher sexual distress and avoidance, and lower sexual satisfaction and function. Our findings highlight the importance of social reactions to sexual violence disclosure in women’s sexuality.
Generation of path-encoded Greenberger-Horne-Zeilinger states

We study the generation of Greenberger-Horne-Zeilinger (GHZ) states of three path-encoded photons. Inspired by the seminal work of Bouwmeester et al. [1] on polarization-entangled GHZ states, we find a corresponding path representation for the photon states of an optical circuit, identify the elements required for the state generation, and propose a possible implementation of our strategy. Besides the practical advantage of employing an integrated system that can be fabricated with proven lithographic techniques, our example suggests that it is possible to enhance the generation efficiency by using microring resonators.
Micro‐environment alterations through time leading to myeloid malignancies

The micro‐environment plays a critical role in haematopoietic stem cell (HSC) development, self‐renewal, differentiation and maintenance by providing a supportive cellular framework and essential molecular cues to sustain homeostasis. In ageing and development of age‐related clonal haematopoiesis, the combined contribution of intrinsic alterations in haematopoietic stem cells and their surrounding micro‐environment can promote myeloid skewing and release of pro‐inflammatory cytokines. A pro‐inflammatory micro‐environment is a common feature in the initiation and sustenance of several myeloid malignancies. Furthermore, remodelling of the micro‐environment is recognized to potentiate the survival of malignant over normal cells. This review explores micro‐environmental interactions in the haematopoietic system of adults, especially how the bone marrow micro‐environment is impacted by ageing, the onset of age‐related clonal haematopoiesis and the development of myeloid malignancies. In addition, we also discuss the possible role age‐related clonal haematopoiesis and chronic inflammatory conditions play in altering the bone marrow micro‐environment dynamics. Finally, we explore the importance of in vitro models that accurately mimic different aspects of the bone marrow micro‐environment in order to study normal and malignant haematopoiesis.
A multi-frame super-resolution algorithm using pocs and wavelet

Super-Resolution (SR) is a generic term, referring to a series of digital image processing techniques in which a high resolution (HR) image is reconstructed from a set of low resolution (LR) video frames or images. In other words, a HR image is obtained by integrating several LR frames captured from the same scene within a very short period of time. Constructing a SR image is a process that may require a lot of computational resources. To solve this problem, the SR reconstruction process involves 3 steps, namely image registration, degrading function estimation and image restoration. In this thesis, the fundamental process steps in SR image reconstruction algorithms are first introduced. Several known SR image reconstruction approaches are then discussed in detail. These SR reconstruction methods include: (1) traditional interpolation, (2) the frequency domain approach, (3) the inverse back-projection (IBP), (4) the conventional projections onto convex sets (POCS) and (5) regularized inverse optimization. Based on the analysis of some of the existing methods, a Wavelet-based POCS SR image reconstruction method is proposed. The new method is an extension of the conventional POCS method, that performs some convex projection operations in the Wavelet domain. The stochastic Wavelet coefficient refinement technique is used to adjust the Wavelet sub-image coefficients of the estimated HR image according to the stochastic F-distribution in order to eliminate the noisy or wrongly estimated pixels. The proposed SR method enhances the resulting quality of the reconstructed HR image, while retaining the simplicity of the conventional POCS method as well as increasing the convergence speed of POCS iterations. Simulation results show that the proposed Wavelet-based POCS iterative algorithm has led to some distinct features and performance improvement as compared to some of the SR approaches reviewed in this thesis.
Use of Facial Morphology to Determine Nutritional Status in Older Adults: Opportunities and Challenges

Undiagnosed malnutrition is a significant problem in high-income countries, which can reduce the quality of life of many individuals, particularly of older adults. Moreover, it can also inflate the costs of existing health care systems because of the many metabolic complications that it can cause. The current methods for assessing malnutrition can be cumbersome. A trained practitioner must be present to conduct an assessment, or patients must travel to facilities with specialized equipment to obtain their measurements. Therefore, digital health care is a possible way of closing this gap as it is rapidly gaining traction as a scalable means of improving efficiency in the health care system. It allows for the remote monitoring of nutritional status without requiring the physical presence of practitioners or the use of advanced medical equipment. As such, there is an increasing interest in expanding the range of digital applications to facilitate remote monitoring and management of health issues. In this study, we discuss the feasibility of a novel digital remote method for diagnosing malnutrition using facial morphometrics. Many malnutrition screening assessments include subjective assessments of the head and the face. Facial appearance is often used by clinicians as the first point of qualitative indication of health status. Hence, there may be merit in quantifying these subtle but observable changes using facial morphometrics. Modern advancements in artificial intelligence, data science, sensors, and computing technologies allow facial features to be accurately digitized, which could potentially allow these previously intuitive assessments to be quantified. This study aims to stimulate further discussion and discourse on how this emerging technology can be used to provide real-time access to nutritional status. The use of facial morphometrics extends the use of currently available technology and may provide a scalable, easily deployable solution for nutritional status to be monitored in real time. This will enable clinicians and dietitians to keep track of patients remotely and provide the necessary intervention measures as required, as well as providing health care institutions and policy makers with essential information that can be used to inform and enable targeted public health approaches within affected populations.
Effects of ε-polylysine and chitooligosaccharides Maillard reaction products on quality of refrigerated sea bass fillets.

BACKGROUND Maillard reaction is a promising and safe method to obtain Chitooligosaccharides conjugates with proteins / peptides as a food preservative. This study aims to investigate the moisture state, physicochemical properties and shelf-life of sea bass fillets treated with ε-polylysine (ε-PL) and chitooligosaccharides (COS) Maillard reaction products (LC-MRPs) during refrigerated storage. RESULTS The results of microbiological analysis and confocal laser scanning microscope (CLSM) revealed that LC-MRPs could effectively retard the microbial growth. Compared with control, ε-PL and COS group, LC-MRPs group could greatly retard the rise of thiobarbituric acid (TBA) value, K-value and total volatile basic nitrogen (TVB-N) value, and also inhibited the softening of texture and the accumulation of biogenic amines in fish. From the results of low-field nuclear magnetic resonance (LF-NMR) and magnetic resonance imaging (MRI), LC-MRPs could delay water migration of fillets and presented higher water holding capacity (WHC). Through sensory evaluation, the application of LC-MRPs increased the shelf-life of refrigerated sea bass fillets for another 9 days. CONCLUSION Maillard reaction products derived from chitooligosaccharides and ε-polylysine have a great potential for the preservation of sea bass. This article is protected by copyright. All rights reserved.