Miracle-dz/UniFAR-FTUs huggingface dataset:
Predicting cognitive stage transition using p‐tau181, Centiloid, and other measures

A combination of plasma phospho‐tau (p‐tau), amyloid beta (Aβ)‐positron emission tomography (PET), brain magnetic resonance imaging, cognitive function tests, and other biomarkers might predict future cognitive decline. This study aimed to investigate the efficacy of combining these biomarkers in predicting future cognitive stage transitions within 3 years.
Effects of Intensive Versus Distributed Constraint-Induced Movement Therapy for Children With Unilateral Cerebral Palsy: A Quasi-Randomized Trial

Background Previous studies have compared the effectiveness of constraint-induced movement therapy (CIMT) by different training doses. However, whether the dosing schedule, that is, intensive or distributed, influences the effectiveness of CIMT in children with unilateral cerebral palsy (CP) is unknown. Objective To investigate the effectiveness of intensive and distributed CIMT for children with unilateral CP. Methods Fifty children with unilateral CP were assigned to intensive or distributed CIMT group with a total of 36 training hours. The intensive CIMT was delivered within 1 week, and the distributed CIMT was delivered twice a week for 8 weeks. The outcomes were the Melbourne Assessment 2, Box and Block Test, Pediatric Motor Activity Log-Revised (PMAL-R), Bruininks–Oseretsky test of motor proficiency 2, ABILHAND-Kids and Parenting Stress Index—Short Form. The intensive group was assessed at the initiation of treatment (week 0), at the end of 1 week treatment (week 1), and 8 weeks after the initiation of treatment (week 8). The distributed group was assessed at week 0 and week 8. Results The within-group analyses demonstrated significant differences on all motor outcomes. There were no significant between-group differences at post-treatment, while the intensive CIMT demonstrated larger improvements than the distributed CIMT did on quality of use of the more-affected hand, as rated by parents on the PMAL-R at week 8. Conclusions The 2 dosing schedules of CIMT had similar effectiveness for children with unilateral CP. The intensive CIMT yielded additional improvement on parent rated motor quality of the more-affected hand at 8 weeks after the initiation of treatment. Trial registration: ClinicalTrials.gov (ID: NCT03128385)
Evaluation of cardiac chamber functions by speckle‐tracking echocardiography in the presence of coronary artery flow disturbances other than stenosis: A review

Conditions other than stenosis also disturb the coronary flow. Such conditions include the coronary slow flow phenomenon, coronary artery ectasia, and coronary artery tortuosity. Evidence exists regarding myocardial dysfunction in these conditions. In this review, we present studies that have used speckle‐tracking echocardiography to determine whether coronary flow disturbances are accompanied by myocardial dysfunction. Additionally, we seek to show the gaps in knowledge concerning this issue and the dimensions that future studies should consider.
Koblitz's Conjecture for the Drinfeld Module

Let E be an elliptic curve over the rationals without complex multiplication such that any elliptic curve Q-isogenous to E has trivial Q-torsion. Koblitz conjectured that the number of primes less than x for which ∣E(Fp)∣ is prime is asymptotic to CE x (logx)2 for CE a real positive constant dependent on E. Miri and Murty showed that for infinitely many p, ∣E(Fp)∣ has at most 16 prime factors using the lower bound sieve and assuming the Generalized Riemann Hypothesis. This thesis generalizes Koblitz’s conjectures to a function field setting through Drinfeld modules. Let φ be a Drinfeld module of rank 2, and Fq a finite field with every Fq[t]-isogeny having no Fq[t]-torsion points and with Endk(φ) = Fq[t]. Furthermore assume that for each monic irreducible l ∈ Fq[t], the extension generated by adjoining the l-torsion points of φ to Fq(t) is geometric. Then there exists a positive constant Cφ depending on φ such that there are more than Cφ qx x2 monic irreducible polynomials P with degree less then x such that χφ(P ) has at most 13 prime factors. To prove this result we develop the theory of Drinfeld modules and a translation of the lower bound sieve to function fields.
Crocin suppresses breast cancer cell proliferation by down‐regulating tumor promoter miR‐122‐5p and up‐regulating tumor suppressors FOXP2 and SPRY2

Crocin has been reported to have antitumor activity in several tumors including breast cancer. Nevertheless, the mechanism of action of crocin on breast cancer remains unclear. The cytotoxicity of crocin was evaluated by CCK‐8 assay. Cell proliferation was assessed using EdU incorporation assay and western blot analysis. Breast cancer‐related genes were extracted from GEPIA. miR‐122‐5p targets were predicted using Targetscan, starbase, and miRDB softwares. Luciferase reporter assay was employed to confirm whether miR‐122‐5p targeted sprouty2 (SPRY2) and forkhead box P2 (FOXP2). Results showed that crocin exhibited cytotoxicity and suppressed the proliferation in breast cancer cells. miR‐122‐5p was upregulated in breast cancer tissues and cells. Crocin suppressed miR‐122‐5p to block the proliferation of breast cancer cells. Seven targets of miR‐122‐5p were identified in breast cancer. SPRY2 and FOXP2 were selected for further experiments due to their involvement in breast cancer. miR‐122‐5p targeted SPRY2 and FOXP2 to inhibit their expression. miR‐122‐5p knockdown restrained breast cancer cell proliferation by targeting SPRY2 and FOXP2. Additionally, crocin increased SPRY2 and FOXP2 expression by inhibiting miR‐122‐5p expression. Together, our results suggested that crocin inhibited proliferation of breast cancer cells through decreasing miR‐122‐5p expression and the subsequent increase of SPRY2 and FOXP2 expression.
Evaluation of oral telmisartan administration as a suppression test for diagnosis of primary hyperaldosteronism in cats

Abstract Background Development of a telmisartan‐based suppression test may facilitate the diagnosis of primary hyperaldosteronism (PHA) in cats, which remains difficult today. Objectives To develop a telmisartan suppression test (TST) that is safe, and able to suppress aldosterone secretion in healthy cats but not in cats with PHA. Animals Ten healthy cats and 6 cats with PHA. Methods Prospective study using a placebo‐controlled crossover design to investigate a TST in healthy cats, and evaluation of TST in cats with PHA. Plasma aldosterone concentration, potassium concentration, and systolic blood pressure (SBP) were measured before (T0), and 1 hour (T1) and 1.5 hours after (T1.5) PO administration of 1 mg/kg of telmisartan, 2 mg/kg of telmisartan or placebo. Results Median age in healthy cats was 3 years old (range, 1‐7). In healthy cats, a telmisartan dose of 2 mg/kg significantly decreased aldosterone concentration at T1 and T1.5 compared with T0. Placebo had no significant effect on aldosterone concentration. In cats diagnosed with PHA, a 2‐mg/kg dose of telmisartan did not induce any significant change in aldosterone concentration at T1 or T1.5 compared with T0. No adverse effects of telmisartan (e.g., hyperkalemia, systemic hypotension) were observed in any cats. Conclusions and Clinical Importance The oral TST shows promise as a diagnostic test for the diagnosis of PHA in cats.
Spotlight on Genetic Kidney Diseases: A Call for Drug Delivery and Nanomedicine Solutions

Nanoparticles as drug delivery carriers have benefited diseases, including cancer, since the 1990s, and more recently, their promise to quickly and efficiently be mobilized to fight against global diseases such as in the COVID-19 pandemic have been proven. Despite these success stories, there are limited nanomedicine efforts for chronic kidney diseases (CKDs), which affect 844 million people worldwide and can be linked to a variety of genetic kidney diseases. In this Perspective, we provide a brief overview of the clinical status of genetic kidney diseases, background on kidney physiology and a summary of nanoparticle design that enable kidney access and targeting, and emerging technological strategies that can be applied for genetic kidney diseases, including rare and congenital kidney diseases. Finally, we conclude by discussing gaps in knowledge remaining in both genetic kidney diseases and kidney nanomedicine and collective efforts that are needed to bring together stakeholders from diverse expertise and industries to enable the development of the most relevant drug delivery strategies that can make an impact in the clinic.
Functional and structural brain network development in children with attention deficit hyperactivity disorder

Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood neurodevelopmental disorder. Given the profound brain changes that occur during childhood and adolescence, it is important to examine longitudinal changes of both functional and structural brain connectivity across development in ADHD. This study aimed to examine the development of functional and structural connectivity in children with ADHD compared to controls using graph metrics. One hundred and seventy five individuals (91 children with ADHD and 84 non‐ADHD controls) participated in a longitudinal neuroimaging study with up to three waves. Graph metrics were derived from 370 resting state fMRI (197 Control, 173 ADHD) and 297 diffusion weighted imaging data (152 Control, 145 ADHD) acquired between the ages of 9 and 14. For functional connectivity, children with ADHD (compared to typically developing children) showed lower degree, local efficiency and betweenness centrality predominantly in parietal, temporal and visual cortices and higher degree, local efficiency and betweenness centrality in frontal, parietal, and temporal cortices. For structural connectivity, children with ADHD had lower local efficiency in parietal and temporal cortices and, higher degree and betweenness centrality in frontal, parietal and temporal cortices. Further, differential developmental trajectories of functional and structural connectivity for graph measures were observed in higher‐order cognitive and sensory regions. Our findings show that topology of functional and structural connectomes matures differently between typically developing controls and children with ADHD during childhood and adolescence. Specifically, functional and structural neural circuits associated with sensory and various higher order cognitive functions are altered in children with ADHD.
Accelerating action to reduce anemia: Review of causes and risk factors and related data needs

Anemia is a major public health concern. Young children, menstruating adolescent girls and women, and pregnant women are among the most vulnerable. Anemia is the consequence of a wide range of causes, including biological, socioeconomic, and ecological risk factors. Primary causes include: iron deficiency; inherited red blood cell disorders; infections, such as soil‐transmitted helminthiasis, schistosomiasis, and malaria; gynecological and obstetric conditions; and other chronic diseases that lead to blood loss, decreased erythropoiesis, or destruction of erythrocytes. The most vulnerable population groups in low‐ and middle‐income countries are often at the greatest risk to suffer from several of these causes simultaneously as low socioeconomic status is linked with an increased risk of anemia through multiple pathways. Targeted and effective action is needed to prevent anemia. Understanding the causes and risk factors of anemia for different population subgroups within a country guides the design and implementation of effective strategies to prevent and treat anemia. A coordinated approach across various expert groups and programs could make the best use of existing data or could help to determine when newer and more relevant data may need to be collected, especially in countries with a high anemia burden and limited information on the etiology of anemia.
How Healthcare Providers Reconcile Bad Things Happening to Good Patients: The Role of Just World Beliefs in Attitudes toward Trauma-Informed Care

ABSTRACT Despite prevalent trauma exposure among patients seeking health care, as well as widespread frameworks for enacting trauma-informed care, the uptake of trauma-informed practices such as trauma screening and referral among health-care providers remains relatively low. The current study sought to assess the roles of health-care providers’ personal histories of adverse childhood experiences (ACEs) and personal beliefs in the just-world hypothesis in understanding their attitudes toward trauma-informed care. Advanced practice graduate nursing students (N = 180; M age = 34.6 years) completed a self-reported survey assessing their personal history of ACEs, global belief in a just world, and attitudes related to trauma-informed care. Results indicated the relation between providers’ ACEs and attitudes toward trauma-informed care was fully mediated by their beliefs in a just world, such that providers reporting higher ACEs scores also report greater endorsement of attitudes consistent with trauma-informed care due to less belief in a just world. Implications for both health-care providers’ themselves and cultural shifts necessary for provision of trauma-informed health care are discussed.
Morphological characteristics convey social status signals in captive tree sparrows (Passer montanus)

In social animals that form flocks, individuals compete or cooperate to gain access to shared resources. In particular, group-foraging individuals frequently engage in aggressive interactions with conspecifics, including threat displays and physical attacks, in order to acquire food resources. Here, we investigated social interactions in flocks of captive tree sparrows (Passer montanus) to observe the formation of dominance hierarchies. We also examined correlations between social status and morphological traits to identify which physical traits act as indicators of dominance. To do so, we recorded aggressive behaviours (attacks and threats) of tree sparrows caught in two distinct regions in the Republic of Korea (Gwangju and Gurye). After merging the two groups, we examined dominance structures using David’s scores for one month, and we recorded 1,051 aggressive interactions at a feeder in a group of 19 individuals. Using the number of aggressions and attack and threat behaviours, we tested whether morphological traits and sex influenced dominance structures. Aggressions were significantly more frequent in males than in females. However, no significant difference was observed the frequency of between- and within-sex aggression. In addition, differences in the frequency of aggression behaviours were observed between capture-site groups. Dominance structure was significantly correlated with certain morphological traits; specifically, the frequency of attacking behaviours was correlated with bill-nose length, and the frequency of threat displays was correlated with sex and badge size. These results suggest that social signals are closely related to morphological traits that are used to form dominance hierarchies in tree sparrow flocks.
Vestibular and visual brain areas in the medial cortex of the human brain.

Self-motion perception involves an interaction between vestibular and visual brain regions. In the lateral brain, it includes the parieto-insular vestibular cortex and the posterior insular cortex. In the medial cortex, the cingulate sulcus visual (CSv) area is known to process visual-vestibular cues. Here, we show that the vestibular-visual network of the medial cortex extends beyond area CSv. We examined brain activations of 36 healthy right-handed participants by functional magnetic resonance imaging (fMRI) during stimulation with caloric vestibular, thermal or visual motion cues. Consistent with previous research, we found that area CSv responded to both vestibular and visual cues but not to thermal cues. Moreover, the V6 complex and the precuneus motion (PcM) area responded primarily to (laminar-translational) visual motion cues. However, we also observed a region inferior to CSv within the pericallosal sulcus (vicinity of anterior retrosplenial) that primarily responded to vestibular cues. This vestibular pericallosal sulcus (vPCS) region did not respond to either visual or thermal cues. It was also distinct from a more posterior motion-sensitive region in the retrosplenial complex (mRSC) that responded to (radial) visual motion but not to vestibular and thermal cues. Together, our results suggest that the vestibular-visual network in the medial cortex not only includes areas CSv, PcM, and the V6 complex, but two additional brain regions adjacent to the callosum. These two brain regions exhibit similarities in terms of their locations and responses to vestibular and visual cues with self-motion related brain regions recently described in non-human primates.
Eye-movements disrupt EEG alpha-band coding of behaviorally relevant and irrelevant spatial locations held in working memory.

Oscillations in the alpha frequency band (~8-12 Hz) of the human electroencephalogram play an important role in supporting selective attention to visual items and maintaining their spatial locations in working memory (WM). Recent findings suggest spatial information maintained in alpha is modulated by interruptions to continuous visual input, such that attention shifts, eye-closure and backward-masking of the encoded item causes reconstructed representations of remembered locations to become degraded. Here, we investigated how another common visual disruption - eye-movements - modulates reconstructions of behaviorally relevant and irrelevant item locations held in WM. Participants completed a delayed estimation task, where they encoded and recalled either the location or color of an object after a brief retention period. During retention, participants either fixated at center or executed a sequence of eye-movements. Electroencephalography (EEG) was recorded at the scalp and eye-position monitored with an eye-tracker. Inverted encoding modeling (IEM) was applied to reconstruct location-selective responses across multiple frequency bands during encoding and retention. Location-selective responses were successfully reconstructed from alpha activity during retention where participants fixated at center, but these reconstructions were disrupted during eye-movements. Recall performance decreased during eye-movement conditions but remained largely intact, and further analyses revealed that under specific task conditions it was possible to reconstruct retained location information from lower frequency bands (1-4 Hz) during eye-movements. These results suggest that eye-movements disrupt maintained spatial information in alpha in a manner consistent with other acute interruptions to continuous visual input, but this information may be represented in other frequency bands.
The association of lipid transfer protein VPS13A with endosomes is mediated by sorting nexin SNX5

Binding of sorting nexin SNX5 to the VAB domain of VPS13A mediates its recruitment to membrane contact sites between SNX5-containing endosomal membranes, mitochondria, and ER. Human VPS13 proteins are implicated in severe neurological diseases. These proteins play an important role in lipid transport at membrane contact sites between different organelles. Identification of adaptors that regulate the subcellular localization of these proteins at specific membrane contact sites is essential to understand their function and role in disease. We have identified the sorting nexin SNX5 as an interactor of VPS13A that mediates its association with endosomal subdomains. As for the yeast sorting nexin and Vps13 endosomal adaptor Ypt35, this association involves the VPS13 adaptor-binding (VAB) domain in VPS13A and a PxP motif in SNX5. Notably, this interaction is impaired by mutation of a conserved asparagine residue in the VAB domain, which is also required for Vps13-adaptor binding in yeast and is pathogenic in VPS13D. VPS13A fragments containing the VAB domain co-localize with SNX5, whereas the more C-terminal part of VPS13A directs its localization to the mitochondria. Overall, our results suggest that a fraction of VPS13A localizes to junctions between the endoplasmic reticulum, mitochondria, and SNX5-containing endosomes.
Antioxidants attenuate mitochondrial oxidative damage through the Nrf2 pathway: A promising therapeutic strategy for stroke

Stroke represents one of the leading causes of disability and death worldwide. Reactive oxygen species overproduction‐induced oxidative stress in mitochondria results in mitochondrial DNA damage, mitochondrial autophagy (mitophagy), inflammation, and apoptosis during the pathologic progression of stroke. Nuclear factor erythroid 2‐related factor 2 (Nrf2) is a master regulator that induces the transcription of a wide range of antioxidant genes to attenuate mitochondrial oxidative stress. Different antioxidative compounds, including polyphenols, mitochondrial antioxidants, triterpenoids, and others, have been shown to be able to activate Nrf2 and, thus, exert neuroprotective effects on stroke by ameliorating mitochondrial oxidative damage. In this review, we briefly discussed the role of mitochondrial oxidative stress in the pathophysiology of stroke and focused on the protective effects of antioxidative compounds through attenuating mitochondrial oxidative damage by activating Nrf2 in stroke. In conclusion, these antioxidants may represent novel therapeutic strategies against stroke.
Homeostatic Regulation of Energetic Arousal During Acute Social Isolation: Evidence From the Lab and the Field

Recent evidence suggests that social contact is a basic need governed by a social homeostatic system. Little is known, however, about how conditions of altered social homeostasis affect human psychology and physiology. Here, we investigated the effects of 8 hr of social isolation on psychological and physiological variables and compared this with 8 hr of food deprivation in a lab experiment (N = 30 adult women). Social isolation led to lowered self-reported energetic arousal and heightened fatigue, comparable with food deprivation. To test whether these findings would extend to a real-life setting, we conducted a preregistered field study during a COVID-19 lockdown (N = 87 adults; 47 women). The drop in energetic arousal after social isolation observed in the lab replicated in the field study for participants who lived alone or reported high sociability, suggesting that lowered energy could be part of a homeostatic response to the lack of social contact.
Sparse Depth-Guided Attention for Accurate Depth Completion: A Stereo-Assisted Monitored Distillation Approach

This paper proposes a novel method for depth completion, which leverages multi-view improved monitored distillation to generate more precise depth maps. Our approach builds upon the state-of-the-art ensemble distillation method, in which we introduce a stereo-based model as a teacher model to improve the accuracy of the student model for depth completion. By minimizing the reconstruction error of a target image during ensemble distillation, we can avoid learning inherent error modes of completion-based teachers. We introduce an Attention-based Sparse-to-Dense (AS2D) module at the front layer of the student model to enhance its ability to extract global features from sparse depth. To provide self-supervised information, we also employ multi-view depth consistency and multi-scale minimum reprojection. These techniques utilize existing structural constraints to yield supervised signals for student model training, without requiring costly ground truth depth information. Our extensive experimental evaluation demonstrates that our proposed method significantly improves the accuracy of the baseline monitored distillation method.