Miracle-dz/UniFAR-FTUs huggingface dataset:
Mortalidade por tuberculose no interior de São Paulo – brasil (2006-2008)/Mortality from tuberculosis in the countryside of São Paulo - Brazil (2006-2008)

This is an epidemiological and descriptive study aiming to characterize the epidemiological profile of deaths due to tuberculosis in the period from 2006 to 2008 of the Regional Health Department III of the State of Sao Paulo, Brazil. The population was selected through reports of tuberculosis cases recorded in the Tuberculosis Patient Control Registers and death certificates with underlying cause of tuberculosis of the residents of the region covered, registered in the Mortality Information System Department. It was observed 640 reported cases in the Tuberculosis System and 34 deaths in the Information System of Mortality. It was possible to identify 22 deaths when both databases were crossed each other. Thus, there were a total of 45 deaths due to tuberculosis, which occurred mostly in male, with a mean age of 30-59 years and the pulmonary form of the disease. Forty-five percent (45%) of the reported cases occurred outside the primary health care, and the mean interval between notification and death indicated a delayed diagnosis in 77% of the cases. In conclusion, the results showed the importance of data entry reviewing in both information systems, beyond of studies to analyze strategies considered for disease control and also to measure the performance of the primary health care in this context.
Vertically integrated projects (VIP) @ the University of Strathclyde : how to enhance the student and staff learning experience through VIP

The purpose of this paper is to outline and share with the wider academic community the experience of developing and implementing Vertically Integrated Projects at the University of Strathclyde during their pilot phase. In turn we consider the results of a preliminary evaluation, paying particular attention to the effects on the student learning experience, (and to a lesser extent the academic staff), and illustrate how those results and our own observations have been used to identify constraints in VIP development and expansion, in addition to those critical factors which have contributed to their success. We conclude with a reflective statement on `moving forward`, in the hope that others will be inspired to follow suit.
Stalled malaria control; root causes and possible remedies

Background: Malaria control has been stalled for some years in many African countries. We suggest reasons for the stalling, and ways of remedying the situation. Methods: We analyse malaria data from Kenya and Tanzania using mathematical analysis and a deterministic model for mosquito and malaria population dynamics. The model was produced in Microsoft Excel and is usable by persons who are neither mathematicians nor specialised modellers. Results: In Kenya, there was no significant decline in malaria incidence during the last decade, despite 50-80% of the human population owning and using insecticide-treated bed-nets (ITN). Similar situations exist in Tanzania and Uganda. There were only limited declines in malaria incidence in Kenyan counties where indoor spraying of residual insecticides covered about 90% of the dwellings. This is especially surprising since, in the earlier decade, a rapid drop in malaria incidence followed much less intense control operations. While there have been well documented increases in resistance of anopheline mosquitoes to various pyrethroids, these are not sufficient to explain the stalled control. Instead, we suggest that this is largely due to a change in the species composition and behaviour of the vector populations, consequent on the widespread use of ITN. Quantitative support for this view is offered by our mathematical analyses and modelling of published data on changes in malaria incidence and levels of access to, and use of, ITN. The modelling also suggests that a resumed decline in the incidence of malaria might best be achieved by increasing ITN coverage as close as possible to 100% and supplementing this effort with limited application of control measures that kill mosquitoes attempting to feed off non-humans. Particular attention deserves to be given to the insecticide treatment of cattle hosts and the refinement of artificial baits for outdoor deployment. Conclusions: Current levels of indoor residual spraying (IRS) and ITN will not result in any significant improvement. If, however, ITN ownership and effective use can be increased closer to 100%, modest levels of additional control outdoors should result in substantial reductions in incidence. Treatment of adult mosquitoes visiting livestock is a promising option.
Production Pattern of Ajmalicine in Catharanthus roseus (L.) G. Don. Cell Aggregates Culture in the Airlift Bioreactor

A research has been conducted to optimize the rate of aeration and initial weight of cell aggregates in the production of ajmalicine in Catharanthus roseus cell culture in airlift bioreactor. Catharanthus roseus culture were grown in Zenk medium with the addition of 2.50 x 10 -6 M naphthalene acetic acid (NAA) and 10 -5 M benzyl amino purine (BAP). Cell aggregates were sub-cultured two times before transferring 20 and 30 g/fw of cell aggregates into bioreactor, respectively, and aerated with the rate of 0.25 l min -1 and 0.34 l min -1 , respectively. The pattern of ajmalicine production in bioreactor were observed in every three days within 24 days. Qualitative and quantitative analysis were conducted using HPLC connected to Cromatopac CL-7A Plus. The results showed that the cell aggregates and medium contain ajmalicine. The highest concentration was obtained in combination of 30 g/fw and 0.34 l min -1 aeration compare to 20 g/fw - 0.25 l min -1 , 20 g/fw - 0.34 l min -1 , as well as 30 g/fw A¢â‚¬â€œ 0.25 l min -1/sup>. The highest ajmalicine content in cell aggregates was obtained on the 12 days (79.23 A‚Âµg g - ) whilst in medium was obtained in the 18 thsup> days (981.15 A‚Âµg l - ). Key words: ajmalicine, cell aggregates culture, C. roseus, airlift bioreactor
Bifurcations and Stability in Models of Infectious Diseases

This work is concerned with bifurcations and stability in models related to various aspects of infectious diseases. First, we study the dynamics of a mathematical model on primary and secondary cytotoxic T-lymphocyte (CTL) responses to viral infections by Wodarz et al. This model has three equilibria and the stability criteria of them are discussed. The system transitions from one equilibrium to the next as the basic reproductive number, R0, increases. When R0 increases even further, we analytically show that periodic solutions may arise from the third equilibrium via Hopf bifurcation. Numerical simulations of the model agree with the theoretical results and these dynamical behaviours occur within biologically realistic parameter ranges. Normal form theory is also applied to find amplitude, phase and stability information on the limit cycles. Biological implications of the results are discussed. After studying the single-strain model, we will analyze the bifurcation dynamics of an in vivo multi-strain model of Plasmodium falciparum. Main attention of this model is focused on the dynamics of cross-reactivity from antigenic variation. We apply the techniques of coupled cell systems to study this model. It is shown that synchronybreaking Hopf bifurcation occurs from a nontrivial synchronous equilibrium. In proving the existence of a Hopf bifurcation, we also discover the condition under which possible 2-colour synchrony patterns arise from the bifurcation. Dynamics resulting from the bifurcation are qualitatively similar to known behaviour of antigenic variation. iii These results are discussed and illustrated with examples and numerical simulations. Aside from the bifurcation of an in vivo multi-strain model, we also study the clustering behaviour found in numerous multi-strain transmission models. Numerical solutions of these models have shown that steady-state, periodic, or even chaotic solutions can be self-organized into clusters. Such clustering behaviour is not a priori expected. It has been proposed that the cross-protection from multiple strains of pathogens is responsible for the clustering phenomenon. We show that the steady-state clusterings in existing models can be analytically predicted. The clusterings occur via semi-simple double zero bifurcations from the quotient network of the models and the patterns which follow can be predicted through the stability analysis of the bifurcation. We calculate the stability criteria for different clustering patterns and show that some patterns are inherently unstable. Finally, the biological implications of these results are discussed.
A for-loop is all you need. For solving the inverse problem in the case of personalized tumor growth modeling

Solving the inverse problem is the key step in evaluating the capacity of a physical model to describe real phenomena. In medical image computing, it aligns with the classical theme of image-based model personalization. Traditionally, a solution to the problem is obtained by performing either sampling or variational inference based methods. Both approaches aim to identify a set of free physical model parameters that results in a simulation best matching an empirical observation. When applied to brain tumor modeling, one of the instances of image-based model personalization in medical image computing, the overarching drawback of the methods is the time complexity for finding such a set. In a clinical setting with limited time between imaging and diagnosis or even intervention, this time complexity may prove critical. As the history of quantitative science is the history of compression, we align in this paper with the historical tendency and propose a method compressing complex traditional strategies for solving an inverse problem into a simple database query task. We evaluated different ways of performing the database query task assessing the trade-off between accuracy and execution time. On the exemplary task of brain tumor growth modeling, we prove that the proposed method achieves one order speed-up compared to existing approaches for solving the inverse problem. The resulting compute time offers critical means for relying on more complex and, hence, realistic models, for integrating image preprocessing and inverse modeling even deeper, or for implementing the current model into a clinical workflow.
A New Hydrodynamic Spherical Accretion Exact Solution and Its Quasi-spherical Perturbations

We present an exact γ = 5/3 spherical accretion solution that modifies the Bondi boundary condition of ρ→constant as r → ∞ to ρ → 0 as r → ∞. This change allows for simple power-law solutions on the density and infall velocity fields, ranging from a cold empty freefall condition where pressure tends to zero, to a hot hydrostatic equilibrium limit with no infall velocity. As in the case of the Bondi solution, a maximum accretion rate appears. As in the γ = 5/3 case of the Bondi solution, no sonic radius appears, this time however, because the flow is always characterized by a constant Mach number. This number equals 1 for the case of the maximum accretion rate, diverges toward the cold empty state, and becomes subsonic toward the hydrostatic equilibrium limit. It can be shown that in the limit r → 0, the Bondi solution tends to the new solution presented, extending the validity of the Bondi accretion value to cases where the accretion density profile does not remain at a fixed constant value out to infinity. We then explore small deviations from sphericity and the presence of angular momentum through an analytic perturbative analysis. Such perturbed solutions yield a rich phenomenology through density and velocity fields in terms of Legendre polynomials, which we begin to explore for simple angular velocity boundary conditions having zeros on the plane and pole. The new solution presented provides complementary physical insight into accretion problems in general.
Following the Data, Not the Function: Rethinking Function Orchestration in Serverless Computing

Serverless applications are typically composed of function workflows in which multiple short-lived functions are triggered to exchange data in response to events or state changes. Current serverless platforms coordinate and trigger functions by following high-level invocation dependencies but are oblivious to the underlying data exchanges between functions. This design is neither efficient nor easy to use in orchestrating complex workflows -- developers often have to manage complex function interactions by themselves, with customized implementation and unsatisfactory performance. In this paper, we argue that function orchestration should follow a data-centric approach. In our design, the platform provides a data bucket abstraction to hold the intermediate data generated by functions. Developers can use a rich set of data trigger primitives to control when and how the output of each function should be passed to the next functions in a workflow. By making data consumption explicit and allowing it to trigger functions and drive the workflow, complex function interactions can be easily and efficiently supported. We present Pheromone -- a scalable, low-latency serverless platform following this data-centric design. Compared to well-established commercial and open-source platforms, Pheromone cuts the latencies of function interactions and data exchanges by orders of magnitude, scales to large workflows, and enables easy implementation of complex applications.
Learning Efﬁcient Policies for Picking Entangled Wire Harnesses: A Solution to Industrial Bin Picking

—Wire harnesses are essential connecting components in manufacturing industry but are challenging to be automated in industrial tasks such as bin picking. They are long, ﬂexible and tend to get entangled when randomly placed in a bin. This makes the robot struggle to pick a single one from the clutter. Besides, modeling wire harnesses is difﬁcult due to the complex structures of combining deformable cables with rigid components, making it unsuitable for training or collecting data in simulation. In this work, instead of directly lifting wire harnesses, we proposed to grasp and extract the target following circle-like trajectories until it is separated from the clutter. We learn a policy from real-world data to infer the optimal action and grasp from visual observation. Our policy enables the robot to perform non-tangle pickings efﬁciently by maximizing success rates and reducing the execution time. To evaluate our policy, we present a set of real-world experiments on picking wire harnesses. Results show a signiﬁcant improvement in success rates from 49.2% to 84.6% over the tangle-agnostic bin picking method. We also evaluate the effectiveness of our policy under different clutter scenarios using unseen types of wire harnesses. The proposed method is expected to provide a practical solution for automating manufacturing processes with wire harnesses.
Localization and a generalization of MacDonald's inner product

We find a limit formula for a generalization of MacDonald's inner product in finitely many variables, using equivariant localization on the Grassmannian variety, and the main lemma from \cite{Car}, which bounds the torus characters of the higher \c{C}ech cohomology groups. We show that the MacDonald inner product conjecture of type $A$ follows from a special case, and the Pieri rules section of MacDonald's book \cite{Mac}, making this limit suitable replacement for the norm squared of one, the usual normalizing constant.
The Workspace Design approach: How users and OHS consultants can transform design scripts

The Danish Workspace Design (WSD) research program is aimed to develop and trial a potential new concept for ergonomists and other workplace consultants who are to engage in socio-technical design processes. The objective of this paper is to report on the trial of the workspace design concept in a case involving the design and implementation of a new mixing technology in an industrial plant. The case showed how the WSD concept can contribute to an engineering design process. The WSD team took the role as workspace designer and by the participatory workshops achieved an impact on the technology project. It was possible to transform the script which the design engineers were sticking to in the early phases of the design process.
Generation of homogeneous granular packings: Contact dynamics simulations at constant pressure using full periodic boundaries

The contact dynamics (CD) method is an ecient simulation technique of dense granular media where unilateral and frictional contact problems for a large number of rigid bodies have to be solved. In this paper, we present a modied version of the CD to generate homogeneous random packings of rigid grains. CD simulations are performed at constant external pressure, which allows the variation of the size of a periodically repeated cell. We follow the concept of the Andersen dynamics and show how it can be applied within the framework of the CD method. The main challenge here is to handle the interparticle interactions properly, which are based on constraint forces in CD. We implement the proposed algorithm, perform test simulations, and investigate the properties of the nal packings.
Hypoxia Image Guided Radiation Therapy: Current Status and Major Challenges

Tumor hypoxia is a major factor contributing to treatment resistance and local recurrence in radiotherapy. Over the years hypoxia has become a target of modulation to improve tumor control in radiotherapy, including hyperbaric oxygenation, hypoxic radiosensitizers, and in recent years, Hypoxia Image Guided Radiotherapy (HIGRT). The HIGRT is one of the biologic image guided radiotherapy methods aiming to delivering higher radiation dose to hypoxic sub-volumes to overcome hypoxia-induced radio resistance. The concept of delivering higher radiation dose to hypoxic tumor tissue became possible reality only after major developments on the non-invasive imaging on hypoxia, especially the PET imaging with hypoxia probes. Several radiation therapy treatment planning studies have been carried out with modulated radiation dose based on hypoxia PET images. However there are several practical challenges to implement the procedure in real clinical condition due to imaging limitation, physiological variation, and limitations on radiation delivery. The article reviews the current status on clinical and preclinical research on HIGRT and major challenges to be addressed in the future development. 18F-[2-(2-nitro-1[H]-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide], HX4: 18F-flortanidazole, Cu-ATSM: Cu-diacetyl-bis(N4-methylthiosemicarbazone); FLT: 3-deoxy-3-[18F]-fluorothymidine; DCE MRI: Dynamic Contrast Enhanced Magnetic Resonance Imaging. study based on metabolic sub-volume from FDG PET and hypoxia sub-volume obtained from 18F-HX4 hypoxia PET imaging [17]. Radiation dose was escalated to 117 ± 15 Gyinhypoxia sub volume [17]. It was demonstrated that high dose to hypoxia volume can be achieved without increasing dose to organs at risk.
Application of kisspeptin in domestic animal reproduction

Kisspeptin id the peptide molecule synthesised naturally in the animals’ body. The Hypothalamic-Pituitary-Gonadal (HPG) axis controls all stages of reproduction. Kisspeptins are several structurally related amidated peptides, which are derived from the differential proteolytic processing of a common precursor of 145 amino acids encoded by the KISS1 gene. Recent studies found that it can turn on productions of LH mainly after stimulating secretion of GnRH and help in oocyte maturation and ovulation. This can help in improvement of farm economy by establishing better reproductive traits. This review describes mode of action of kisspeptins and its application in animal reproduction.
303-307 Загоровский

Electrochemical sensors have large perspectives for exploration to presence of toxic compounds in environment determination. It have been shown advan tages of paste electrodes of multi-walled carbon nanotubes to mercury (II) and chromium (VI) content in aqueous medium determination. The role of oxygen-containing groups at the nanotubes tips to the metal ions adsorption was discussed. These electrod es allow to determinate Hg (II) content in water at th e lowest limit of 20 ng ⋅dm and Cr (VI) in concentration interval of 50–150 mcg ⋅dm.
Equitable Compensatory System and Efficiency of the Cameroon Customs Administration

— This paper explores the concept of compensation and benefits in HRM, its link with organizational performance and perspectives for a better and more equitable compensatory system in the Cameroon Customs administration. In that vein the author based its study on theories relating to equity and fairness and an in-depth analysis of the economics of Social Credit’s philosophy. It must be recalled that much has been written about these concepts, but so far there is no integrated conceptual framework available for the Cameroon customs administration. Our goal here is to develop such a framework and ameliorate the existing pattern. We do this in a number of steps, starting with a presentation of the existing approaches, models, theories with respect to compensation system, equity and performance. The research methodology used is based on a mixed approach that implies a triangulation of qualitative and quantitative methods in order to address efficiently the research problem. I conclude with the presentation of recommendations and suggestions for further research. The sample for the study is comprised of 70 employees drawn from the 3895 personnel constituting the Cameroon Customs administration. A total of 70 questionnaires were distributed to selected employees. Out of these, 50 questionnaires were duly filled and returned. From analysis it appears that75 % of the participants indicated that strategic planning of HR can effectively lead to efficiency of the Cameroon Customs administration. It is therefore recommended for organizations to put in place compensation and benefits schemes based on clearly defined and objective performance criteria. Furthermore the mechanism for distribution should be transparent. The author advises use of electronic means .