Miracle-dz/UniFAR-FTUs huggingface dataset:
EVALUATION OF QUALITY LOSS IN A FISH BASED, READY-TO-EAT FOOD (FISH ROLL) DURING REFRIGERATED STORAGE

In this study, samples of commercially sold fish roll snacks, were kept for 30days in refrigerated storage at 4 o C and subjected to biochemical evaluation. Biochemical parameters showed a rising trend in pH, peroxide value, free fatty acid with trimethylamine (TMA) values increasing significantly during storage. Results of biochemical analyses indicated that the fish roll samples were still fit for consumption at the end of the experiment. fatty acid (FFA) content was determined in the lipid extract according to the Lowry and Tinsley (1976) method based on a complex formation with cupric acetate-pyridine followed by spectrophotometric (715nm) assessment. Results are expressed as g FFA 100g- 1 lipids. The peroxide value (PV) was determined in the lipid extract by peroxide reduction with ferric cynanate according to Chapman and Mckay (1949) method. Results were expressed as meq active oxygen kg- 1 lipids. The trimethylamine (TMA) content in the samples were determined by the micro-diffusion method of Conway (1968).
A NOVEL APPROACH BASED ON ACTIVE CONSTRAINT FOR MINIMIZING VAR IN THE PORTOFOLIO OPTIMIZATION PROBLEM

The portfolio optimization mathematical model is more frequently expressed with an eye to minimize the Value at Risk (VaR). Markowitz's difficulties in managing the quadratic programming model were alleviated by recent advances in algorithmic analysis, which sparked interest in overcoming real constraints in portfolio selection by introducing a linear risk function. The point of this article is to address the issue of portfolio selection of minimum transaction lots. An improved search algorithm appertaining to active constraints is presented to interpret the integer programming model. The algorithm leads by solving the relaxed problem in order to reach a settlement that is similar to a continuous solution.
Title: Store-operated STIM1 translocation and interaction with TRPC1 at the plasma membrane stimulates PLC activity to induce channel gating in vascular smooth muscle cells

In entry pathways which regulate contractility, proliferation and migration. It is therefore important to understand how these channels are activated. Studies have shown that stimulation of TRPC1-based SOCs requires activities and PKC phosphorylation, but it is unclear how store depletion stimulates this gating pathway. The present work examines this issue by focusing on the role of STIM1, an endo/sarcoplasmic 110 reticulum Ca 2+ sensor. Store-operated TRPC1 channel activity was inhibited by TRPC1 and 111 STIM1 antibodies and STIM1 shRNA in wild-type VSMCs, and was absent in TRPC1 -/- 112 VSMCs. Store-operated PKC phosphorylation of TRPC1 was reduced by knockdown of 113 STIM1. Moreover, store-operated PLCβ1 activity measured with the fluorescent PIP 2 /InsP 3 114 biosensor GFP-PLCδ1-PH was reduced by STIM1 shRNA and absent in TRPC1 -/- cells. 115 Immunocytochemistry, co-immunoprecipitation, and proximity ligation assays revealed that 116 store depletion activated STIM1 translocation from within the cell to the plasma membrane 117 (PM) where it formed STIM1-TRPC1 complexes, which then associated with G  q and 118 PLCβ1. Noradrenaline also evoked TRPC1 channel activity and associations between TRPC1, STIM1, G  q and PLCβ1, which were inhibited by STIM1 knockdown. Effects of N- 120 terminal and C-terminal STIM1 antibodies on TRPC1-based SOCs and STIM1 staining 121 suggest that channel activation may involve insertion of STIM1 into the PM. Our findings identify a new activation mechanism of TRPC1-based SOCs in VSMCs, and a novel role for STIM1, in which store-operated STIM1-TRPC1 interactions stimulate PLC  1 activity to induce PKC
Occurrence of isopod parasite on alepes kleinii (Bloch, 1793) from Mumbai and Goa coast of India

Parasitological examination, on Alepes kleinii (Bloch 1793) (family: Carangidae) from Mumbai Coast and Goa Coast. India was carried out on 182 specimens (117 from Mumbai Coast and 65 from Goa Coast), collected between August 2015 to May 2016. During examination 20 specimens were found to be infested with isopod Norileca indica (Isopod: Cymothoidae) from Mumbai Coast and 15 specimens from Goa Coast; mostly attached to gills. Others were located in the mouth cavity where the tongue itself was replaced by the parasite in most cases. The size of parasite was varied from 14 to 20.1 mm long and 5.8 to 8 mm wide at Mumbai Coast and 14.6 to17.6 mm long and 6.1 to 6.95 mm wide at Goa Coast, whereas the size of fish varied from 84.92-174.36 mm TL at Mumbai Coast and 85.12-148.12 mm TL at Goa Coast. Prevalence of infection was observed to 23.08% at Mumbai Coast while, 16.81% at Goa Coast. The lowest percentage of infection in A. kleinii at Mumbai Coast was 10% and at Goa Coast it was 9.09%. The overall prevalence, mean intensity and abundance of infestation with isopod were found to be 16.81%, 1.183, 0.271 at Mumbai Coast and 23.08%, 1.33, 0.308 on Goa Coast. The highest prevalence of parasite infection was observed in the month of October in Mumbai Coast and in March on the Goa Coast.
Hypocrisy in ethical consumption

When making consumption choices, people often fail to meet their own standards of both ethics and frugality. People also generally tend to demand more of others than they do of themselves. But little is known about how these different types of hypocrisy interact, particularly in relation to attitudes toward ethical consumption. In three experiments, we integrate research methods using anchoring and hypocrisy within the context of ethical consumption. Across three experiments, we find a default expectation that people (particularly people other than ourselves) should spend less on consumer items than they actually do. This default position can be inverted by making the ethical context of consumption salient, whereby the expectation is then that people (particularly other people) should spend more on consumer items than they actually do. Experiments 2 and 3 show that a moderate price anchor for ethical consumption is sufficient to shift expected standards for other people, but a higher price anchor is required to shift expected standards in personal behaviour. We discuss the countervailing roles of frugality and ethical consumption in understanding hypocrisy and ethical decision-making.
Lung adenocarcinoma-related target gene prediction and drug repositioning

Lung cancer is the leading cause of cancer deaths globally, and lung adenocarcinoma (LUAD) is the most common type of lung cancer. Gene dysregulation plays an essential role in the development of LUAD. Drug repositioning based on associations between drug target genes and LUAD target genes are useful to discover potential new drugs for the treatment of LUAD, while also reducing the monetary and time costs of new drug discovery and development. Here, we developed a pipeline based on machine learning to predict potential LUAD-related target genes through established graph attention networks (GATs). We then predicted potential drugs for the treatment of LUAD through gene coincidence-based and gene network distance-based methods. Using data from 535 LUAD tissue samples and 59 precancerous tissue samples from The Cancer Genome Atlas, 48,597 genes were identified and used for the prediction model building of the GAT. The GAT model achieved good predictive performance, with an area under the receiver operating characteristic curve of 0.90. 1,597 potential LUAD-related genes were identified from the GAT model. These LUAD-related genes were then used for drug repositioning. The gene overlap and network distance with the target genes were calculated for 3,070 drugs and 672 preclinical compounds approved by the US Food and Drug Administration. At which, bromoethylamine was predicted as a novel potential preclinical compound for the treatment of LUAD, and cimetidine and benzbromarone were predicted as potential therapeutic drugs for LUAD. The pipeline established in this study presents new approach for developing targeted therapies for LUAD.
Gradient normalized least-squares reverse-time migration imaging technology

Least-squares reverse-time migration (LSRTM) can overcome the problems of low resolution and unbalanced amplitude energy of deep formation imaging in reverse-time migration (RTM); hence, it can obtain a more accurate imaging profile. In the conventional conjugate gradient LSRTM, the gradient is obtained based on cross correlation without a precondition operator, and the source has a great influence on the gradient, causing the convergence rate to be slow. In the framework of conventional conjugate gradient LSRTM, a normalized cross-correlation of the source wavefield was used in this study to effectively weaken the influence of the source effect and reduce the low-frequency noise. The idea of normalized cross-correlation of the source wavefield was adopted to improve the steepest descent gradient to further accelerate the iterative convergence speed and complete the final migration imaging. Model and field data examples verify the advantages of the proposed methods over conventional methods in reducing source effects, improving convergence speed, and enhancing underground deep illumination.
Engineering bone-forming callus organoid implants in a xenogeneic-free differentiation medium

The field of tissue engineering aspires to provide clinically relevant solutions for patients through the integration of developmental engineering principles with a bottom-up manufacturing approach. However, the manufacturing of cell-based advanced therapy medicinal products is hampered by protocol complexity, lack of non-invasive critical quality controls, and dependency on animal-derived components for tissue differentiation. We investigate a serum-free, chemically defined, xeno- and lipid-free chondrogenic differentiation medium to generate bone-forming callus organoids. Our results show an increase in microtissue homogeneity during prolonged differentiation and the high quality of in vivo bone-forming organoids. The low protein content of the culture medium potentially allows for the monitoring of relevant secreted biomarkers as (critical) quality attributes. Together, we envisage that this xeno- and lipid-free chondrogenic medium is compatible with industrial scale-up and automation while facilitating the implementation of non-invasive imaging and the use of quality control parameters based on secreted biomarkers.
Fibrosis in fat: From other diseases to Crohn’s disease

Creeping fat is a specific feature of Crohn’s disease (CD) and is characterized by mesenteric fat wrapping around the intestine. It highly correlates with intestinal transmural inflammation, muscular hypertrophy, fibrosis, and stricture formation. However, the pathogenesis of creeping fat remains unclear. Molecular crosstalk exists between mesenteric fat and the intestine. Indeed, creeping fat contains different types of cells, including adipocytes and immune cells. These cell types can produce various cytokines, fatty acids, and growth factors, which affect the mesenteric fat function and modulate intestinal inflammation and immunity. Moreover, adipocyte progenitors can produce extracellular matrix to adapt to fat expansion. Previous studies have shown that fat fibrosis is an important feature of adipose tissue malfunction and exists in other diseases, including metabolic disorders, cancer, atrial fibrillation, and osteoarthritis. Furthermore, histological sections of CD showed fibrosis in the creeping fat. However, the role of fibrosis in the mesenteric fat of CD is not well understood. In this review, we summarized the possible mechanisms of fat fibrosis and its impact on other diseases. More specifically, we illustrated the role of various cells (adipocyte progenitors, macrophages, mast cells, and group 1 innate lymphoid cells) and molecules (including hypoxia-inducible factor 1-alpha, transforming growth factor-beta, platelet-derived growth factor, and peroxisome proliferator-activated receptor-gamma) in the pathogenesis of fat fibrosis in other diseases to understand the role of creeping fat fibrosis in CD pathogenesis. Future research will provide key information to decipher the role of fat fibrosis in creeping fat formation and intestinal damage, thereby helping us identify novel targets for the diagnosis and treatment of CD.
Legitimizing user knowledge in mental health services: Epistemic (in)justice and barriers to knowledge integration

Including the voices and knowledge of service users is essential for developing recovery-oriented and evidence-based mental health services. Recent studies have however, suggested that challenges remain to the legitimization of user knowledge in practice. To further explore such challenges, a co-production study was conducted by a team of researchers and representatives from user organizations in Sweden. The aim of the study was to explore the barriers and facilitators to the legitimacy of user knowledge, as a central factor in sustainably implementing user influence in mental health practice. A series of workshops, with representatives of mental health services and user organizations were conducted by the research team to explore these issues. The analysis built on the theoretical framework of epistemic injustice, and the underlying aspects, testimonial, hermeneutic and participation-based injustice, were utilized as a framework for a deductive analysis. Results suggest that this is a useful model for exploring the complex dynamics related to the legitimacy of user knowledge in mental health systems. The analysis suggests that the legitimacy of user knowledge is related to the representativeness of the knowledge base, the systematic formulation of this knowledge in applicable methods, access to resources and positions within the mental health system and participation in the process of integrating this knowledge-base in mental health contexts. Legitimizing user knowledge in practice additionally challenges mental health systems to support readiness for change in working environments and to address the power and role issues that these changes involve.
Closing the loop – The human role in artificial intelligence for education

Recent advancements in artificial intelligence make its use in education more likely. In fact, existing learning systems already utilize it for supporting students’ learning or teachers’ judgments. In this perspective article, we want to elaborate on the role of humans in making decisions in the design and implementation process of artificial intelligence in education. Therefore, we propose that an artificial intelligence-supported system in education can be considered a closed-loop system, which includes the steps of (i) data recording, (ii) pattern detection, and (iii) adaptivity. Besides the design process, we also consider the crucial role of the users in terms of decisions in educational contexts: While some implementations of artificial intelligence might make decisions on their own, we specifically highlight the high potential of striving for hybrid solutions in which different users, namely learners or teachers, are provided with information from artificial intelligence transparently for their own decisions. In light of the non-perfect accuracy of decisions of both artificial intelligence-based systems and users, we argue for balancing the process of human- and AI-driven decisions and mutual monitoring of these decisions. Accordingly, the decision-making process can be improved by taking both sides into account. Further, we emphasize the importance of contextualizing decisions. Potential erroneous decisions by either machines or humans can have very different consequences. In conclusion, humans have a crucial role at many stages in the process of designing and using artificial intelligence for education.
The relationship between renal function and surgical outcomes of patients with proliferative diabetic retinopathy

Objectives The relationship between renal function and diabetic retinopathy has been controversial. This study is to investigate the influence of renal function on the complex and surgical outcomes of proliferative diabetic retinopathy (PDR). Methods This was a post hoc analysis of the CONCEPT clinical trial. A total of 45 eyes with PDR underwent vitrectomy were included. Based on the estimated glomerular filtration rate (eGFR), they were divided into abnormal renal function group (ARF group) and normal renal function group (NRG group). Baseline PDR complex, intraoperative outcomes (Intraoperative bleeding, frequency of endodiathermy, surgical time, iatrogenic hole, and tamponade) and postoperative outcomes (logMAR best-corrected visual acuity, vitreous re-hemorrhage, and macular edema, follow up at postoperative 1 month and 3 months) were estimated. Vitreous, aqueous humor and serum were collected at the vitrectomy day and Vascular endothelia growth factor-A levels were quantified for all included patients using liquid chip method. Results There was no significant difference in baseline PDR complex, intraoperative and postoperative outcomes between ARF group and NRG group (all P > 0.05). At the vitrectomy day, there was also no difference of Vascular endothelia growth factor-A levels in vitreous, aqueous humor and serum between the two groups (all P > 0.05). Conclusion Our results showed that the renal function seems not parallel to the severity of PDR, neither to the surgical outcomes. This might be interpreted by the similar Vascular endothelia growth factor-A levels in vitreous, aqueous humor and serum between the two groups.
Extracellular traps and the role in thrombosis

Thrombotic complications pose serious health risks worldwide. A significant change in our understanding of the pathophysiology of thrombosis has occurred since the discovery of extracellular traps (ETs) and their prothrombotic properties. As a result of immune cells decondensing chromatin into extracellular fibers, ETs promote thrombus formation by acting as a scaffold that activates platelets and coagulates them. The involvement of ETs in thrombosis has been reported in various thrombotic conditions including deep vein thrombosis (DVT), pulmonary emboli, acute myocardial infarction, aucte ischemic stroke, and abdominal aortic aneurysms. This review summarizes the existing evidence of ETs in human and animal model thrombi. The authors described studies showing the existence of ETs in venous or arterial thrombi. In addition, we studied potential novel therapeutic opportunities related to the resolution or prevention of thrombosis by targeting ETs.
Polysomnographic nighttime features of Restless Legs Syndrome: A systematic review and meta-analysis

Background Restless Legs Syndrome (RLS) is a common sleep disorder. Polysomnographic (PSG) studies have been used to explore the night sleep characteristics of RLS, but their relationship with RLS has not been fully analyzed and researched. Methods We searched the Cochrane Library electronic literature, PubMed, and EMBASE databases to identify research literature comparing the differences in polysomnography between patients with RLS and healthy controls (HCs). Results This review identified 26 studies for meta-analysis. Our research found that the rapid eye movement sleep (REM)%, sleep efficiency (SE)%, total sleep time (TST) min, and N2 were significantly decreased in patients with RLS compared with HCs, while sleep latency (SL) min, stage shifts (SS), awakenings number (AWN), wake time after sleep onset (WASO) min, N1%, rapid eye movement sleep latency (REML), and arousal index (AI) were significantly increased. Additionally, there was no significant difference among N3%, slow wave sleep (SWS)%, and apnea-hypopnea index (AHI). Conclusion Our findings demonstrated that architecture and sleep continuity had been disturbed in patients with RLS, which further illustrates the changes in sleep structure in patients with RLS. In addition, further attention to the underlying pathophysiological mechanisms of RLS and its association with neurodegenerative diseases is needed in future studies.
Effects of dietary palygorskite supplementation on the growth performance, oxidative status, immune function, intestinal barrier and cecal microbial community of broilers

The present study aimed to investigate the effects of palygorskite (PAL) as an alternative to antibiotic on the growth performance, oxidative status, immune function, intestinal barrier and cecal microbial community of broilers. A total of 360 1-day-old male Ross-308 broilers were randomly allotted to three treatments with eight replicates. Broilers in the three groups were designated as follows: basal diet (CON group), basal diet+50 mg/kg chlorotetracycline (ANT group), and basal diet+ 10 g/kg PAL (PAL group). Supplementing PAL reduced feed to gain ratio in broilers during 22 to 42 days of age (P < 0.05), with its value being similar to that of the ANT group (P > 0.05). Broilers fed a PAL-supplemented diet exerted decreased contents of interferon-γ (IFN-γ) and interleukin-1β in serum, and the same reduction was found in jejunal IFN-γ level, when compared to the CON group (P < 0.05). Moreover, compared with the CON group, broilers after PAL treatment had a lower malondialdehyde content in jejunal mucosa (P < 0.05). Supplementing PAL elevated jejunal villus height (VH) and ratio of VH to crypt depth compared with the ANT group (P < 0.05). Cecal microbiota communities among the three groups were significant different, as demonstrated by distinct clusters from partial least squares discriminant analysis, although dietary treatments had no significant effects on the bacterial richness and diversity indices (P > 0.05). At genus level, the addition of PAL increased the relative abundance of norank_f__Barnesiellaceae and decreased that of unclassified_f__Oscillospiraceae in cecal digesta compared with those in the CON group (P < 0.05); the proportion of genus norank_f__Barnesiellaceae was increased by PAL treatment when compared with the ANT group (P < 0.05). Moreover, spearman's correlations showed that the modulation of cecal microflora composition by PAL supplementation was closely correlated with the promotion of growth performance (feed to gain ratio) and intestinal health-related (contents of malondialdehyde and IFN-γ, and VH value in jejunum) variables of broilers (P < 0.05). Taken together, dietary PAL could improve the growth performance, antioxidant capacity, and immune status, as well as intestinal barrier function in broilers, which might be partially associated with the alteration of cecal microbiota. Moreover, dietary PAL may be a promising alternative to antibiotic growth promoter for broilers.