Miracle-dz/UniFAR-FTUs huggingface dataset:
What Lies Beneath

Rating: Explicit Archive Warning: Graphic Depictions Of Violence, Rape/Non-Con Category: F/M Fandom: IT (2017), IT Stephen King Relationship: Pennywise (IT)/Reader Character: Pennywise (IT), Original Characters, Bill Denbrough, Eddie Kaspbrak, Ben Hanscom, Richie Tozier, Stanley Uris, Mike Hanlon, Beverly Marsh Additional Tags: you Freeform, reader Freeform, Reader-Insert, Vaginal Sex, Vaginal Fingering, Licking, Blood and Gore, Clowns, Smut, Porn With Plot, Violence, Explicit Sexual Content, Human Form, Hand Jobs, Blow Jobs, BDSM, Orgasm Delay/Denial, Slow Build, Sexual Tension, Violent Thoughts, Dark Character, Emotional Hurt/Comfort, Emotional Manipulation, Strong Female Characters Series: Part 1 of What Lies Beneath Stats: Published: 2017-09-26 Completed: 2019-09-06 Chapters: 20/20 Words: 95976
Passive immunization against oral AIDS virus transmission: An approach to prevent mother‐to‐infant HIV‐1 transmission?

To develop immunoprophylaxis regimens against mother‐to‐child human immunodeficiency virus type 1 (HIV‐1) transmission, we established a simian–human immunodeficiency virus (SHIV) model in neonatal macaques that mimics intrapartum mucosal virus exposure (T.W. Baba, J. Koch, E.S. Mittler et al.: AIDS Res Hum Retroviruses 10:351–357, 1994). We protected four neonates from oral SHIV‐vpu+ challenge by ante‐ and postpartum treatment with a synergistic triple combination of immunoglobulin (Ig) G1 human anti‐HIV‐1 neutralizing monoclonal antibodies (mAbs) (T.W. Baba, V. Liska, R. Hofmann‐Lehmann et al.: Nature Med 6:200–206, 2000), which recognize the CD4‐binding site of Env, a glycosylation‐dependent gp120, or a linear gp41 epitope. Two neonates that received only postpartum mAbs were also protected from oral SHIV‐vpu+ challenge, indicating that postpartum treatment alone is sufficient. Next, we evaluated a similar mAb combination against SHIV89.6P, which encodes env of primary HIV89.6. One of four mAb‐treated neonates was protected from infection and two maintained normal CD4+ T‐cell counts. We conclude that the epitopes recognized by the three mAbs are important determinants for achieving protection. Combination immunoprophylaxis with synergistic mAbs seems promising to prevent maternal HIV‐1 transmission in humans.
Volatile Constituents of Valeriana hardwickii Wall. Root Oil from Arunachal Pradesh, Eastern Himalaya

The composition of the essential oil extracted from Valeriana hardwickii Wall. roots growing wild in Talle Valley of Arunachal Pradesh, Eastern Himalaya was analyzed by capillary GC and GC/MS. Thirty-one compounds representing 89.6% of the total oil were identified. The oil was found to be rich in sesquiterpenes from which oxygenated sesquiterpenes (25.7%). Methyl linoleate (21.1%) and Valeracetate (11.6%) were the major constituents present in the oil. Whereas, Bornyl acetate (11.2%) and α-Terpinyl acetate (4.7%) were the only oxygenated monoterpenes identified in the investigated sample. Essential oil and its constituents of V. hardwickii may be used as the substitute of highly traded Indian Valerian (V. jatamansi) and European V. officinalis.
Romantic relationships: an important context for HIV/STI and pregnancy prevention programmes with young people

Romantic relationships are central in the lives of young people. This paper uses data on romantic relationships from urban youth in the USA to illustrate how using a relationships perspective in HIV/STI and pregnancy prevention programmes broadens the skills and content covered, and contextualises the learning to enhance relevance and use. Self-report survey data were collected using electronic handheld devices for a school-based randomised trial. The survey sample includes 911 young people (mean age = 12.4 years) representative of their schools. Logistic regressions explored associations between selected sexual behaviours and relationship characteristics. For all participants, having more boy/girlfriends, dating alone, ever touching and ever having had oral sex were associated with an increased likelihood of having vaginal sex. Among young people with current partners, having a partner three or more years older, length of relationship and ever having oral sex were associated with an increased likelihood of having vaginal sex. The study data confirm the importance of accounting for relationships in sexual risk reduction programmes, and provide avenues for enhancing the relevancy of typical school-based prevention programmes.
A study of intracity variation of temperature-related mortality and socioeconomic status among the Chinese population in Hong Kong

Background Hong Kong, a major city in China, has one of the world's highest income inequalities and one of the world's highest average increases in urban ambient temperatures. Heat-related mortality in urban areas may vary with acclimatisation and population characteristics. This study examines how the effect of temperature on mortality is associated with sociodemographic characteristics at an intracity level in Hong Kong, China, during the warm season. Methods Data from the Hong Kong Observatory, Census and Statistics Department, Environmental Protection Department and government general outpatient clinics during 1998–2006 were used to construct generalised additive (Poisson) models to examine the temperature mortality relationship in Hong Kong. Adjusted for seasonality, long-term trends, pollutants and other potential confounders, effect modification of the warm season temperature–mortality association by demographic, socioeconomic factors and urban design were examined. Results An average 1°C increase in daily mean temperature above 28.2°C was associated with an estimated 1.8% increase in mortality. Heat-related mortality varied with sociodemographic characteristics: women, men less than 75 years old, people living in low socioeconomic districts, those with unknown residence and married people were more vulnerable. Non-cancer-related causes such as cardiovascular and respiratory infection-related deaths were more sensitive to high temperature effects. Conclusion Public health protection strategies that target vulnerable population subgroups during periods of elevated temperature should be considered.
Body mass index but not pulse pressure is associated with lesser penile-vaginal intercourse frequency in healthy young men.

INTRODUCTION A growing literature links aspects of sexual and cardiovascular function. Recent research revealed that pulse pressure (systolic minus diastolic) was associated with poorer erectile function (and hypogonadism) in male patients with erectile dysfunction. It is unclear to what degree pulse pressure (and body mass index) would be associated with aspects of sexual function in a younger, healthy sample (controlling for possible confounders). AIMS To examine the associations of frequency of specific sexual behaviors with both resting pulse pressure and body mass index. METHODS Sixty-five healthy young men (mean age 25.2 +/- 4.6 years) had their resting blood pressure, weight, and height recorded, and reported the frequency of their various sexual activities. MAIN OUTCOME MEASURES Correlations of pulse pressure with different sexual behaviors (univariate and adjusted for possible confounding variables including age, mean blood pressure, body mass index, social desirability responding score, and cohabitation status). RESULTS For these healthy young men, on univariate and adjusted analyses, pulse pressure was not significantly associated with frequencies of penile-vaginal intercourse, other partnered sexual activity, or masturbation. In contrast, body mass index was associated with lesser frequency of penile-vaginal intercourse but not other sexual behaviors. CONCLUSIONS The association of pulse pressure with sexual function previously observed in older men was not observed in this younger healthy sample. Other measures of arterial stiffness might be indicated in a healthy young population. Even within the normal range and adjusted for possible confounders, increasing body mass index (a rough proxy for body fat) is associated with reduced frequency of specifically penile-vaginal intercourse, which might be a result of some combination of characterological and hormonal factors.
Anti-citrullinated peptide antibodies may occur in patients with psoriatic arthritis

Background: Anti-cyclic citrullinated peptide (anti-CCP) antibodies are considered highly specific markers of rheumatoid arthritis. Despite the high specificity of the test, anti-CCP antibodies have also been observed in psoriatic arthritis. Objective: To determine the frequency of anti-CCP antibodies in psoriatic arthritis and to describe the clinical characteristics of such patients. Methods: Serum samples from 192 patients with psoriatic arthritis were analysed for anti-CCP antibodies. A previously defined cut off point was applied at a specificity level of ⩾98.5% (42 U/ml). Antibodies against pepA and pepB (two synthetic citrullinated peptides) were determined on samples containing anti-CCP antibodies by line immune assay. The swollen joint count and the numbers of affected joints (present or past) were recorded. Clinical features were noted and if available radiographs of hands and feet were scored for erosions. Rheumatoid factor was determined in all samples. Results: Anti-CCP antibodies were found in 15 patients (7.8%); 13 of 15 anti-CCP2 positive samples were also positive for anti-pepA or pepB antibodies. The prevalence of anti-CCP antibodies was higher than expected in view of the highly specific cut off applied in the test. Detailed analysis of the clinical and radiological features makes it improbable that the high prevalence of anti-CCP antibodies resulted solely from concomitant psoriasis and rheumatoid arthritis or from misclassification. Conclusions: Anti-CCP antibodies may be present in patients with psoriatic arthritis. Although some of the present cohort could have had psoriasis with concomitant rheumatoid arthritis, a proportion at least had the typical characteristics of psoriatic arthritis as the primary diagnosis.
Asian Creativity: A Response to Satoshi Kanazawa

This article responds to Satoshi Kanazawa's thoughtful and entertaining comments about my article concerning the Asian future of evolutionary psychology. Contra Kanazawa's argument that Asian cultural traditions and/or character inhibit Asian scientific creativity, I review historical evidence of high Asian creativity, and psychometric evidence of high Asian intelligence (a cognitive trait) and openness to experience (a personality trait) — two key components of creativity. Contra Kanazawa's concern that political correctness is a bigger threat to American evolutionary psychology than religious fundamentalism, I review evidence from research funding patterns and student attitudes suggesting that fundamentalism is more harmful and pervasive. Finally, in response to Kanazawa's focus on tall buildings as indexes of national wealth and creativity, I find that 13 of the world's tallest 25 buildings are in China, Hong Kong, or Taiwan — of which 11 were built in the last decade. Asian creativity, secularism, and architectural prominence point to a bright future for Asian science.
Fibrosis Severity as a Determinant of Cause-Specific Mortality in Patients With Advanced Nonalcoholic Fatty Liver Disease: A Multi-National Cohort Study.

BACKGROUND & AIMS Little is known about the natural course of nonalcoholic fatty liver disease (NAFLD) with advanced fibrosis. We describe long-term outcomes and evaluate the effects of clinical and histologic parameters on disease progression in patients with advanced NAFLD. METHODS We conducted a multi-national study of 458 patients with biopsy-confirmed NAFLD with bridging fibrosis (F3, n = 159) or compensated cirrhosis (222 patients with Child-Turcotte-Pugh scores of A5 and 77 patients with scores of A6), evaluated from April 1995 through November 2013 and followed until December 2016, death, or liver transplantation at hepatology centers in Spain, Australia, Hong Kong, and Cuba. Biopsies were re-evaluated and scored; demographic, clinical, laboratory, and pathology data for each patient were collected from the time of liver biopsy collection. Cox proportional and competing risk models were used to estimate rates of transplantation-free survival and major clinical events and to identify factors associated with outcomes. RESULTS During a mean follow-up time of 5.5 years (range, 2.7-8.2 years), 37 patients died, 37 received liver transplants, 88 had initial hepatic decompensation events, 41 developed hepatocellular carcinoma, 14 had vascular events, and 30 developed nonhepatic cancers. A higher proportion of patients with F3 fibrosis survived transplantation-free for 10 years (94%; 95% confidence interval [CI], 86%-99%) than of patients with cirrhosis and Child-Turcotte-Pugh A5 (74%; 95% CI, 61%-89%) or Child-Turcotte-Pugh A6 (17%; 95% CI, 6%-29%). Patients with cirrhosis were more likely than patients with F3 fibrosis to have hepatic decompensation (44%; 95% CI, 32%-60% vs 6%, 95% CI, 2%-13%) or hepatocellular carcinoma (17%; 95% CI, 8%-31% vs 2.3%, 95% CI, 1%-12%). The cumulative incidence of vascular events was higher in patients with F3 fibrosis (7%; 95% CI, 3%-18%) than cirrhosis (2%; 95% CI, 0%-6%). The cumulative incidence of nonhepatic malignancies was higher in patients with F3 fibrosis (14%; 95% CI, 7%-23%) than cirrhosis (6%; 95% CI, 2%-15%). Death or transplantation, decompensation, and hepatocellular carcinoma were independently associated with baseline cirrhosis and mild (<33%) steatosis, whereas moderate alcohol consumption was associated with these outcomes only in patients with cirrhosis. CONCLUSIONS Patients with NAFLD cirrhosis have predominantly liver-related events, whereas those with bridging fibrosis have predominantly nonhepatic cancers and vascular events.
Very recent onset rheumatoid arthritis: clinical and serological patient characteristics associated with radiographic progression over the first years of disease.

OBJECTIVES Despite early recognition and disease modifying anti-rheumatic drug (DMARD) treatment, a sizable proportion of early rheumatoid arthritis (RA) patients show radiological progression. This study was performed to determine the frequency of erosive arthritis and the pace of radiological progression in an inception cohort of patients with very early RA (<or=3 months after onset of symptoms). METHODS In order to determine possible prognostic factors for development of erosive disease, we linked the clinical features of these patients to radiological progression in a regression model. About 55 patients with RA and follow-up of at least 3 yrs were analysed. All had complete series of clinical, serological and radiographic assessments. Radiographs were scored according to the Larsen method. RESULTS Erosive disease developed in 63.6% of the patients over 3 yrs, with the majority (74.3%) appearing already in the first and 97.2% by the end of the second year. Among all variables available, rheumatoid factor (RF) and/or anti-cyclic citrullinated peptide (anti-CCP) first presentation were the most predictive for both development of erosions and the degree of radiological progression. None of the clinical variables at the onset was useful to discriminate between erosive and non-erosive patients. In the final regression model, however, cumulative clinical activity substantially contributed to explaining radiological progression. CONCLUSION Despite early treatment, substantial damage occurred in some patients and was associated with presence of strong 'constitutive' predictors such as anti-CCP and RF as well as presence of high long-term clinical disease activity as indicated by C-reactive protein (CRP), swollen joint counts and the absence of a good clinical response (assessed by the failure to achieve lasting low disease activity).
Toll-Like Receptor 4 Is Involved in Inflammatory and Joint Destructive Pathways in Collagen-Induced Arthritis in DBA1J Mice

In rheumatoid arthritis, a significant proportion of cytokine and chemokine synthesis is attributed to innate immune mechanisms. TLR4 is a prominent innate receptor since several endogenous ligands known to activate the innate immune system bind to it and may thereby promote joint inflammation. We generated TLR4 deficient DBA1J mice by backcrossing the TLR4 mutation present in C3H/HeJ strain onto the DBA1J strain and investigated the course of collagen-induced arthritis in TLR4 deficient mice in comparison to wild type littermates. The incidence of collagen- induced arthritis was significantly lower in TLR4 deficient compared to wild type mice (59 percent vs. 100 percent). The severity of arthritis was reduced in the TLR4 deficient mice compared to wild type littermates (mean maximum score 2,54 vs. 6,25). Mice deficient for TLR4 were virtually protected from cartilage destruction, and infiltration of inflammatory cells was reduced compared to wt mice. In parallel to the decreased clinical severity, lower anti-CCP antibody concentrations and lower IL-17 concentrations were found in the TLR4 deficient mice. The study further supports the role of TLR4 in the propagation of joint inflammation and destruction. Moreover, since deficiency in TLR4 led to decreased IL-17 and anti-CCP antibody production, the results indicate a link between TLR4 stimulation and the adaptive autoimmune response. This mechanism might be relevant in human rheumatoid arthritis, possibly in response to activating endogenous ligands in the affected joints.
A model of growth and employment in the open dualistic economy: The cases of Korea and Taiwan

In this paper, the pressing problem of unemployment in the contemporary developing world is studied from an historical perspective of transition growth, i.e. the process representing the termination of economic colonialism and the initiation of modern growth. This problem is investigated for a particular type of LDC, namely, the open dualistic labour surplus economy. The post‐war (1950–70) experience of Taiwan and Korea were analyzed from this viewpoint—emphasizing the fine differences as well as the family resemblance among these countries. As ex‐Japanese colonies, both these countries shared a relatively strong agricultural infrastructure and the open dualistic and labour surplus characteristic at the beginning of the transition in the 1950s. However, as we show, Taiwan had an initially more favourable set of institutional and economic conditions in agriculture.
Voluntary Appointment of Independent Directors in Taiwan: Motives and Consequences

This study explores factors that motivate firms to increase board independence in the absence of legal requirements to do so. In addition, we examine the impact of voluntary enhancement of board independence on firm performance. Using a sample of listed companies in Taiwan, we show that voluntary appointment of independent directors is associated with both economic factors and managerial power. Specifically, we find that board independence increases with the weaknesses of alternative corporate governance mechanisms and the severity of agency problems. However, board independence decreases with managerial ownership and family control. In addition, by employing a simultaneous equations model with selectivity, we provide evidence supporting the positive performance impact of voluntary appointment of independent directors in Taiwan.
The Power of the Internet in China: Citizen Activism Online Guobin Yang New York: Columbia University Press, 2009 xv + 302 pp. $29.50; £20.50 ISBN 978-0-231-14420-9

reality is that throughout the history of the People’s Republic, Chinese veterans and their families often experienced poor treatment and abuse from local officials and the general public. Despite the role of the PLA in the Maoist state and the role of PLA veterans as heroes of the revolution, Diamant documents a consistent pattern of discrimination in terms of jobs, residential rights, medical care and so forth. He finds that this pattern of neglect holds for all Chinese veterans whether they are veterans of the revolution and the war against Japan (1927–49) or the wars against India (1962) and Vietnam (1979). Diamant explores the gap between official rhetoric and the actual treatment of veterans; an important part of the book is its comparative analysis of what conditions lead to better, or worse, treatment of veterans. Diamant raises a number of intriguing arguments about why the nature of the Chinese Revolution led to poor treatment of the revolution’s military heroes. Another key component of the book’s argument is that the problems faced by Chinese veterans raise important questions about the nature of Chinese nationalism and patriotism, and the legitimacy of the regime. Diamant uses the treatment of veterans in everyday life and the attitudes towards veterans expressed by local officials and ordinary citizens as a proxy for assessing regime legitimacy, arguing that the treatment of veterans is an indirect comment on the “legitimacy and rightness of the cause they represent” (p.34). Diamant further suggests that attitudes towards veterans indicate that patriotism in China is poorly developed. Diamant’s discussion of nationalism, patriotism and Chinese veterans will certainly be challenged by some. In many places he appears to be getting ahead of the evidence in his questioning of just how nationalist and patriotic Chinese are. Nevertheless, he raises provocative questions that will serve to enlighten debate on Chinese nationalism and what it means for Chinese society. Overall, the book sheds much-needed light on an understudied topic. Diamant does an excellent job of using archival material to improve our understanding of Chinese veterans in the Maoist era and adds to our understanding of politics and social issues in that era. His chapter on the post-Mao era raises issues, such as the role of veterans in protests, that have been discussed elsewhere but merit further research and discussion. The book also does a good job of bringing in examples from the US, Israel, Vietnam, the Soviet Union, Germany and Britain to provide a comparative context for his analysis of veterans issues in China. The author clearly has a passion for this topic. He is deeply concerned with veterans and how they are treated, whether in China or elsewhere. Hopefully it will encourage further research and bring more scholarly attention to the comparative study of veterans’ issues.
Species-specific insecticide resistance to imidacloprid and fipronil in the rice planthoppers Nilaparvata lugens and Sogatella furcifera in East and South-east Asia.

BACKGROUND In 2003 the development of insecticide resistance against neonicotinoids in the brown planthopper (BPH), Nilaparvata lugens (Stål) (Homoptera: Delphacidae), was first observed in Thailand and has since been found in other Asian countries such as Vietnam, China and Japan. However, the LD(50) values of BPH and the whitebacked planthopper (WBPH), Sogatella furcifera (Horváth), against both neonicotinoid and phenylpyrazole insecticides have been poorly reported in many Asian countries. RESULTS The topical LD(50) values for imidacloprid in the BPH populations collected from East Asia (Japan, China, Taiwan) and Vietnam in 2006 were 4.3-24.2 microg g(-1) and were significantly higher than those collected from the Philippines (0.18-0.35 microg g(-1)). The BPH populations indicated a positive cross-resistance between imidacloprid and thiamethoxam. Almost all the WBPH populations from Japan, Taiwan, China, Vietnam and the Philippines had extremely large LD(50) values (19.7-239 microg g(-1) or more) for fipronil, except for several populations from the Philippines and China. CONCLUSION Species-specific changes in insecticide susceptibility were found in Asian rice planthoppers (i.e. BPH for imidacloprid and WBPH for fipronil). Insecticide resistance in BPH against imidacloprid occurred in East Asia and Indochina, but not in the Philippines. In contrast, insecticide resistance in WBPH against fipronil occurred widely in East and South-east Asia.