Miracle-dz/UniFAR-FTUs huggingface dataset:
The Pathological Effects of Circulating Hydrophobic Bile Acids in Alzheimer’s Disease

Recent clinical studies have revealed that the serum levels of toxic hydrophobic bile acids (deoxy cholic acid, lithocholic acid [LCA], and glycoursodeoxycholic acid) are significantly higher in patients with Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI) when compared to control subjects. The elevated serum bile acids may be the result of hepatic peroxisomal dysfunction. Circulating hydrophobic bile acids are able to disrupt the blood-brain barrier and promote the formation of amyloid-β plaques through enhancing the oxidation of docosahexaenoic acid. Hydrophobic bile acid may find their ways into the neurons via the apical sodium-dependent bile acid transporter. It has been shown that hydrophobic bile acids impose their pathological effects by activating farnesoid X receptor and suppressing bile acid synthesis in the brain, blocking NMDA receptors, lowering brain oxysterol levels, and interfering with 17β-estradiol actions such as LCA by binding to E2 receptors (molecular modelling data exclusive to this paper). Hydrophobic bile acids may interfere with the sonic hedgehog signaling through alteration of cell membrane rafts and reducing brain 24(S)-hydroxycholesterol. This article will 1) analyze the pathological roles of circulating hydrophobic bile acids in the brain, 2) propose therapeutic approaches, and 3) conclude that consideration be given to reducing/monitoring toxic bile acid levels in patients with AD or aMCI, prior/in combination with other treatments.
A Miniaturized Multi‐Frequency Wide‐Band Leaky Wave Button Antenna for ISM/5G Communications and WBAN Applications

A low‐profile multi‐frequency leaky wave button antenna for body‐centric communications is presented. A leaky wave antenna loaded with U‐slots (a combination of U‐slots and slits) and tapered slot structures to improve the radiation efficiency, broadside radiation pattern, and widen the steering range is designed. Furthermore, it comprises a whole ground to meet the Specific Absorption Rate standard requirements based on the known standards. The antenna's performances are examined for on and off‐body conditions. For demonstration, a prototype is implemented, and the measurement is performed on the chest. The antenna operates at multi bands of 1.7–3.3 GHz (Industrial, Scientific, and Medical and 5G communication) and 4.15–10 GHz (sub‐6 GHz and X‐band communications). The peak gains of 6.9 and 8.2 dBi were obtained for on and off‐ body conditions, respectively. Furthermore, the antenna offers maximum radiation efficiencies of 89.3% and 99.3% for on‐body and free‐space conditions. The specific absorption rate (SAR) values obtained for body‐centric communications meet the regulation requirements (e.g., on body tissue at 3.2 GHz, it is 0.78 (1 g) and 0.44 (10 g) W/kg). With an overall miniaturized size, the proposed button antenna could be integrated with clothes. In addition, a multi‐wide bandwidth, circularly polarized radiation, a small size, high efficiency and gain, and low SAR values prove that the proposed antenna can be a potential candidate for wireless body area network and simultaneous wireless information and power transfer applications.
Two-dimensional global low-frequency oscillations in a separating boundary-layer flow

A separated boundary-layer flow at the rear of a bump is considered. Two-dimensional equilibrium stationary states of the Navier–Stokes equations are determined using a nonlinear continuation procedure varying the bump height as well as the Reynolds number. A global instability analysis of the steady states is performed by computing two-dimensional temporal modes. The onset of instability is shown to be characterized by a family of modes with localized structures around the reattachment point becoming almost simultaneously unstable. The optimal perturbation analysis, by projecting the initial disturbance on the set of temporal eigenmodes, reveals that the non-normal modes are able to describe localized initial perturbations associated with the large transient energy growth. At larger time a global low-frequency oscillation is found, accompanied by a periodic regeneration of the flow perturbation inside the bubble, as the consequence of non-normal cancellation of modes. The initial condition provided by the optimal perturbation analysis is applied to Navier–Stokes time integration and is shown to trigger the nonlinear ‘flapping’ typical of separation bubbles. It is possible to follow the stationary equilibrium state on increasing the Reynolds number far beyond instability, ruling out for the present flow case the hypothesis of some authors that topological flow changes are responsible for the ‘flapping’.
PIDE and Solution Related to Pricing of L'evy Driven Arithmetic Type Floating Asian Options

We propose a stochastic model to develop a pricing partial integro-differential equation (PIDE) and its Fourier transform expression for floating Asian options based on the It\^o-L\'evy calculus. The stock price is driven by a class of infinite activity L\'evy processes leading to the market inherently incomplete, and dynamic hedging is no longer risk free. We first develop a PIDE for floating Asian options, and apply the Fourier transform to derive a pricing expression. Our main contribution is to develop a PIDE with its closed form pricing expression for the contract. The procedure is easy to implement for all class of L\'evy processes. Finally, the model is calibrated with the market data and its accuracy is presented.
Modified entropy based least square channel estimation technique for 5G massive multiple input multiple output universal filtered multicarrier systems

These days’ Massive multiple input multiple output (mMIMO) systems have become popular because of their enhanced data transmission rates, robustness against multipath fading, enhanced spectral efficacy, and ability to communicate with a more significant number of users with immense coverage. The critical challenge of the mMIMO systems is precisely replenishing the channel state information (CSI), along with the synchronization between receiver and transmitter. The CSI has recovered with the help of various channel estimation (CE) techniques. This paper presents a modified entropy-based least square CE technique for 5G mMIMO-UFMC systems. The proposed CE technique performance is novel and better than the Least Square (LS) and minimum mean square error (MMSE) CE techniques. The proposed CE technique was evaluated using MATLAB, and its performance results are shown in the simulation. The performance results of the proposed CE are evaluated based on the mean square error (MSE) and bit error rate (BER) of the obtained signal. The executed results prove that the proposed CE is efficient compared to conventional CE methods. The performance of the MCM techniques with respect to the proposed CE is also presented in this paper. This paper also explains the analytical assessment of the LS, MMSE, and MELS CE techniques. The results show that at high values of SNR, the proposed algorithm outperforms the LS and MMSE for both BER and MSE.
Enhancement of 3D Printability by FDM and Electrical Conductivity of PLA/MWCNT Filaments Using Lignin as Bio-Dispersant

To increase the applications of FDM (fusion deposition modeling) 3D printing in electronics, it is necessary to develop new filaments with good electrical properties and suitable processability. In this work, polymer composites filament-shaped with superior electrical performance based on polylactic acid (PLA) carbon nanotubes and lignin blends have been studied by combining solution mixing and melt blending. The results showed that composites achieve electrical percolation from 5 wt. % of nanotubes, with high electrical conductivity. Moreover, the introduction of a plasticizing additive, lignin, improved the printability of the material while increasing its electrical conductivity (from (1.5 ± 0.9)·10−7 S·cm−1 to (1.4 ± 0.9)·10−1 S cm−1 with 5 wt. % carbon nanotubes and 1 wt. % lignin) maintaining the mechanical properties of composite without additive. To validate lignin performance, its effect on PLA/MWCNT was compare with polyethylene glycol. PEG is a well-known commercial additive, and its use as dispersant and plasticizer in PLA/MWCNT composites has been proven in bibliography. PLA/MWCNT composites display easier processability by 3D printing and more adhesion between the printed layers with lignin than with PEG. In addition, the polyethylene glycol produces a plasticizing effect in the PLA matrix reducing the composite stiffness. Finally, an interactive electronic prototype was 3D printed to assess the printability of the new conducting filaments with 5 wt. % of MWCNT.
Survey of maneuvering target tracking. Part I. Dynamic models

This is the first part of a comprehensive and up-to-date survey of the techniques for tracking maneuvering targets without addressing the so-called measurement-origin uncertainty. It surveys various mathematical models of target motion/dynamics proposed for maneuvering target tracking, including 2D and 3D maneuver models as well as coordinate-uncoupled generic models for target motion. This survey emphasizes the underlying ideas and assumptions of the models. Interrelationships among models and insight to the pros and cons of models are provided. Some material presented here has not appeared elsewhere.
Deficiency of the RNA-binding protein ELAVL1/HuR leads to the failure of endogenous and exogenous neuroprotection of retinal ganglion cells

Introduction ELAVL1/HuR is a keystone regulator of gene expression at the posttranscriptional level, including stress response and homeostasis maintenance. The aim of this study was to evaluate the impact of hur silencing on the age-related degeneration of retinal ganglion cells (RGC), which potentially describes the efficiency of endogenous neuroprotection mechanisms, as well as to assess the exogenous neuroprotection capacity of hur-silenced RGC in the rat glaucoma model. Methods The study consisted of in vitro and in vivo approaches. In vitro, we used rat B-35 cells to investigate, whether AAV-shRNA-HuR delivery affects survival and oxidative stress markers under temperature and excitotoxic insults. In vivo approach consisted of two different settings. In first one, 35 eight-week-old rats received intravitreal injection of AAV-shRNA-HuR or AAV-shRNA scramble control. Animals underwent electroretinography tests and were sacrificed 2, 4 or 6 months after injection. Retinas and optic nerves were collected and processed for immunostainings, electron microscopy and stereology. For the second approach, animals received similar gene constructs. To induce chronic glaucoma, 8 weeks after AAV injection, unilateral episcleral vein cauterization was performed. Animals from each group received intravitreal injection of metallothionein II. Animals underwent electroretinography tests and were sacrificed 8 weeks later. Retinas and optic nerves were collected and processed for immunostainings, electron microscopy and stereology. Results Silencing of hur induced apoptosis and increased oxidative stress markers in B-35 cells. Additionally, shRNA treatment impaired the cellular stress response to temperature and excitotoxic insults. In vivo, RGC count was decreased by 39% in shRNA-HuR group 6 months after injection, when compared to shRNA scramble control group. In neuroprotection study, the average loss of RGCs was 35% in animals with glaucoma treated with metallothionein and shRNA-HuR and 11.4% in animals with glaucoma treated with metallothionein and the scramble control shRNA. An alteration in HuR cellular content resulted in diminished photopic negative responses in the electroretinogram. Conclusions Based on our findings, we conclude that HuR is essential for the survival and efficient neuroprotection of RGC and that the induced alteration in HuR content accelerates both the age-related and glaucoma-induced decline in RGC number and function, further confirming HuR’s key role in maintaining cell homeostasis and its possible involvement in the pathogenesis of glaucoma.
Radiation and scattering analysis of infinite arrays of endfire slot antennas with a ground plane

A Green's function moment-method analysis of infinite arrays of endfire slot antennas is described that includes the constant width slot antenna (CWSA) and the linearly tapered slot antenna (LTSA), with a ground plane. The method utilizes an application of equivalence at a plane in front of the array which facilitates the extension of this analysis to antennas printed on protruding dielectric sheets and/or the addition of a radome. Numerical calculations are compared with waveguide simulator experiments for CWSA and LTSA arrays as well as several less complex problem. Relevant numerical considerations and convergence issues are also discussed. >
Role of mycoprotein as a non-meat protein in food security and sustainability: a review

ABSTRACT Malnutrition is increasing across the globe owing to urbanization, poverty, and climatic changes. In the current circumstances, alternative and unexplored sources of food and nutrients are getting attention. The current sources of food cannot meet the ever-increasing population demand. The demand for animal-source protein is estimated be double due to a projected 50% rise in the world population by the year 2050. Moreover, global animal protein supply chains are not only vulnerable to natural disasters but also a significant source of greenhouse gas emissions. Mycoprotein is considered an excellent alternative to animal protein due to its amino acid profile and cost-effectiveness. Mycoprotein is produced by Fusarium venenatum, a naturally occurring fungus that can be used as a substitute for conventional animal protein sources. Mycoprotein is high in protein and fiber while low in cholesterol, fat, sugar, and salt. Mycoprotein offers excellent functional and therapeutic potential in mitigating various health disorders. Furthermore, it helps maintain muscle synthesis and optimal plasma and cholesterol levels, regulating insulin, glucose, and satiety. This review is focused on the mycoprotein’s origin and production, with a particular emphasis on its nutritional, health, and economic opportunities and challenges.
SOCIAL MEDIA MARKETING AND ITS INFLUENCE ON BRAND LOYALTY TOWARDS FAST FASHION BRANDS AMONG VIETNAMESE MILLENNIALS

In an experience-driven world, social media increasingly influences Vietnamese consumers in how they behave, perceive brands, and purchase decision-making, especially millennial consumers. Hence, fast fashion brands have transformed networking sites into an ideal marketing instrument to accelerate their penetration into the Vietnam market. The main purpose of this study is to illuminate the relationship between Social Media Marketing and Brand Loyalty towards fast fashion brands among Vietnamese millennials, underpinned the Stimulus-Organism-Response (S-O-R) model. The secondary purpose is to explore whether Social Media Marketing would be indirectly associated with Brand Loyalty through Brand Trust, Brand Image, and Self-Congruence. This study adopts a quantitative research approach and a cross-sectional research design. Using non-probability sampling, 268 valid responses are obtained from participants aged 26 to 41. As a result, the findings shed light on how social media marketing positively affected brand loyalty through the mediating effect of brand trust, brand image, and self-congruence. It contributes to the existing literature with four critical outcomes, broadening the theoretical scope of online consumer behavior. These findings are beneficial for fast fashion brands, marketers, and practitioners in emerging countries to develop and strengthen millennial customers’ loyalty.
Estimating the prevalence of primary headache disorders in university students: Application of the Croatian version of the HARDSHIP questionnaire

Background: Studies reporting the prevalence of headaches in Croatia have methodological differences that make it difficult to consolidate their results. This study aimed to assess the prevalence of the most common primary headaches in a student population using the standardized HARDSHIP questionnaire (in Croatian). Methods: This cross-sectional epidemiological study collected data regarding the 1-year prevalence of headaches in a student population using the diagnostic algorithm of the HARDSHIP questionnaire. The chi-squared test was used to analyze gender differences, and Cramer’s V was used for effect size interpretation. Results: The questionnaire was administered to 1350 university students enrolled in health profession programs (81.3% female; 18.7% male; average age: 23 years). The 1-year prevalence of migraine was 38.9% (male: female ratio, 1:1.5), and that of tension-type headache was 35.6% (male: female ratio, 1:0.9). Overall, 91.0% of participants responded positively to the question regarding the incidence of headache in the past 12 months. Conclusions: We report a high prevalence of primary headaches among students of health professions in Croatia. The differences in prevalence may be attributed to various sociocultural, geographical, genetic, and methodological differences. Population-specific studies may facilitate a more accurate assessment of headache prevalence and enable more effective targeting of public health activities.
The soft criteria of competitiveness: A symbiosis of trust and knowledge

Abstract The majority of research on competitiveness is based on the analysis of quantitative data. There is significantly less research on the soft elements of competitiveness. This research aims to fill this gap in the literature. Starting from the national culture, the authors investigated the impact of trust characteristics of organisational culture on the characteristics of strategy, knowledge management and organisational effectiveness. Respondents (∑943) from five countries on three continents (USA, China, Hungary, Slovakia, Romania) took part in the quantitative research conducted with a questionnaire survey. The analysis was performed using the SPSS and AMOS 27 programs based on the SEM model. The results show that there is a significant relationship between the examined elements of competitiveness (strategy and management), which also show a significant relationship with organisational trust. Through a culture of trust, the interaction between the elements has a significant impact on the characteristics influencing the efficient operation of the organisation and its competitiveness, regardless of the value of Hofstede’s characteristics of different national cultures.
Spectrum-optimized Si-based III-V multijunction photovoltaics

A III-V/Si metamorphic epitaxy approach to achieve multi-junction solar cells having nearly ideal optical partitioning of the solar spectrum is described. Following our previously-established methodology for the growth of defect-free GaP on Si(100) substrates and demonstrations of heteroepitaxially integrated III-V-on-Si photovoltaics via GaAsyP1-y metamorphic buffers, we discuss work undertaken on the further development and refinement of these processes and materials, with the goal of minimization of threading dislocation densities in order to enable high-performance solar cells. A substantial, non-trivial increase in growth temperature and general improvement of growth conditions and designs has been achieved for both the heterovalent GaP/Si epitaxial integration process and the GaAsyP1-y compositional grading. Improved dislocation glide and significantly more efficient epitaxial relaxation is found for the GaP/Si system, while enhanced dislocation glide dynamics in the metamorphic GaAsyP1-y buffer system is demonstrated by the evolution of new epitaxial tilt characteristics.
Complex Mixtures: Array PBPK Modeling of Jet Fuel Components

An array physiologically-based pharmacokinetic (PBPK) model represents a streamlined method to simultaneously quantify dosimetry of multiple compounds. To predict internal dosimetry of jet fuel components simultaneously, an array PBPK model was coded to simulate inhalation exposures to one or more selected compounds: toluene, ethylbenzene, xylenes, n-nonane, n-decane, and naphthalene. The model structure accounts for metabolism of compounds in the lung and liver, as well as kinetics of each compound in multiple tissues, including the cochlea and brain regions associated with auditory signaling (brainstem and temporal lobe). The model can accommodate either diffusion-limited or flow-limited kinetics (or a combination), allowing the same structure to be utilized for compounds with different characteristics. The resulting model satisfactorily simulated blood concentration and tissue dosimetry data from multiple published single chemical rat studies. The model was then utilized to predict tissue kinetics for the jet fuel hearing loss study (JTEH A, 25:1-14). The model was also used to predict rat kinetic comparisons between hypothetical exposures to JP-8 or a Virent Synthesized Aromatic Kerosene (SAK):JP-8 50:50 blend at the occupational exposure limit (200 mg/m3). The array model has proven useful for comparing potential tissue burdens resulting from complex mixture exposures.
The PV Cep/GM29 nebulosity: an update

An optical polarisation map of the PV Cep/GM29 nebulosity shows that the intermittent streak is a reflection effect produced by sporadic illumination of the eastern edge of the nebula by the central star, PV Cep. The polarization pattern in the nebulosity immediately surrounding PV Cep is not typical of a simple reflection nebula and a polarized source model is proposed to account for this feature. The model also explains the variability of the polarization of the nebula and apical star.
Overview of the TurbSim Stochastic Inflow Turbulence Simulator

The TurbSim stochastic inflow turbulence code was developed to provide a numerical simulation of a full-field flow that contains coherent turbulence structures that reflect the proper spatiotemporal turbulent velocity field relationships seen in instabilities associated with nocturnal boundary layer flows that are not represented well by the IEC Normal Turbulence Models (NTM). Its purpose is to provide the wind turbine designer with the ability to drive design code (FAST or MSC.ADAMS) simulations of advanced turbine designs with simulated inflow turbulence environments that incorporate many of the important fluid dynamic features known to adversely affect turbine aeroelastic response and loading.