Miracle-dz/UniFAR-FTUs huggingface dataset:
Combined Remaining Life Prediction of Multiple Bearings Based on EEMD-BILSTM

To improve the accuracy of a symmetrical structural rolling bearing life prediction under noise interference, a multi-bearing life prediction method combining Ensemble Empirical Mode Decomposition (EEMD) and Bi-directional Long Short-Term Memory (BiLSTM) is proposed. First, EEMD is proposed to decompose the original vibration signal to obtain a finite number of Intrinsic Mode Function (IMF), and the IMFs are further filtered by combining the correlation criterion and kurtosis criterion. Then, the time domain features and frequency domain features of the reconstructed signal are filtered by monotonicity index to obtain the set of features containing key information. Finally, the BiLSTM network is trained on the filtered features set, and the method is proved to accurately predict the remaining life of rolling bearings under different operating conditions through rolling bearing full-life experiments, and the effectiveness of the method is verified by comparing the prediction results with several main recurrent neural networks.
Long non-coding RNA CCDC144NL-AS1 promotes cell proliferation by regulating the miR-363-3p/GALNT7 axis in colorectal cancer

Colorectal cancer (CRC) is a burdensome health concern worldwide. Long non-coding RNA (lncRNA) have emerged as vital roles in multiple cancers, including CRC. Increasing evidence has demonstrated that lncRNA CCDC144NL-AS1 acts crucial roles in tumor developments. Nevertheless, its role in CRC remains largely unknown. The level of CCDC144NL-AS1 expression was detected in 100 CRC tissues and paired adjacent tissues. The gain- and loss-of-function experiments were conducted to investigate the biological functions of CCDC144NL-AS1 in vitro and in vivo. The potential mechanism of CCDC144NL-AS1 exerting as competing endogenous RNAs (ceRNAs) was demonstrated by bioinformatics, luciferase reporter assay and in vitro experiments. CCDC144NL-AS1 was up-regulated in CRC tissues and cells. High CCDC144NL-AS1 was connected with the adverse clinicopathological features and worse prognosis of CRC. Furthermore, knockdown of CCDC144NL-AS inhibited the cell proliferation and led to the cell cycle G0-1/S arrest, whereas upregulated CCDC144NL-AS1 obtained the inverse results. Further study found that CCDC144NL-AS1 functioned as ceRNAs in regulating CRC proliferation. MiR-363-3p was the target of CCDC144NL-AS1, which sponges GALNT7 in regulating cell growth of CRC. The study demonstrated that the CCDC144NL-AS1/miR-363-3p/GALNT7 axis exerts on key roles in cell proliferation and presents an emerging target for CRC therapy and prognostic biomarker.
How Does Bank Competition Affect Banking Stability? The Case of an Emerging Market

This paper examines the role of interbank competition on banking stability in Jordan, an emerging market. Using competition estimates measured by Lerner index, the paper examines the impact of competition on two important dimensions of banking stability, namely, credit risk and liquidity risk. The empirical results suggest that the effect of banking competition on stability differs according to the dimension of stability. After controlling for bank-level control variables and macroeconomic conditions, the empirical results of the impact of market power measured by Lerner index on credit risk show that an increase in price competition leads to more risk taking from banks. On the other hand, the impact of price competition on the second dimension of banking stability (liquidity risk) implies that an increase in price competition improves the liquidity position of banks. However, these results hold only for the sample of non-Islamic banks. Islamic banks may face wider mismatch between its assets and liabilities due to its inability to use conventional debt instruments offered by the market and hence it keeps larger cash buffers to compensate for this extra risk.
Failure diagnosis system for CRH3 electrical multiple unit

Based on the description of train formation structure,train communication network and train control system of CRH3Electrical Multiple Unit(EMU),coding rules for the equipment coding and location oriented to fault diagnosis system were analyzed.The general architecture of CRH3EMU failure diagnosis system was elaborated and the structure and function of diagnosis documentation system were analyzed in detail which was the core diagnosis knowledge management system.This failure diagnosis system provided strong support for the safe operation of CRH3EMU.
Targeting Tumor Glycans for Cancer Therapy: Successes, Limitations, and Perspectives

Simple Summary Aberrant glycosylation is a common feature of many cancers, and it plays crucial roles in tumor development and biology. Cancer progression can be regulated by several physiopathological processes controlled by glycosylation, such as cell–cell adhesion, cell–matrix interaction, epithelial-to-mesenchymal transition, tumor proliferation, invasion, and metastasis. Different mechanisms of aberrant glycosylation lead to the formation of tumor-associated carbohydrate antigens (TACAs), which are suitable for selective cancer targeting, as well as novel antitumor immunotherapy approaches. This review summarizes the strategies developed in cancer immunotherapy targeting TACAs, analyzing molecular and cellular mechanisms and state-of-the-art methods in clinical oncology. Abstract Aberrant glycosylation is a hallmark of cancer and can lead to changes that influence tumor behavior. Glycans can serve as a source of novel clinical biomarker developments, providing a set of specific targets for therapeutic intervention. Different mechanisms of aberrant glycosylation lead to the formation of tumor-associated carbohydrate antigens (TACAs) suitable for selective cancer-targeting therapy. The best characterized TACAs are truncated O-glycans (Tn, TF, and sialyl-Tn antigens), gangliosides (GD2, GD3, GM2, GM3, fucosyl-GM1), globo-serie glycans (Globo-H, SSEA-3, SSEA-4), Lewis antigens, and polysialic acid. In this review, we analyze strategies for cancer immunotherapy targeting TACAs, including different antibody developments, the production of vaccines, and the generation of CAR-T cells. Some approaches have been approved for clinical use, such as anti-GD2 antibodies. Moreover, in terms of the antitumor mechanisms against different TACAs, we show results of selected clinical trials, considering the horizons that have opened up as a result of recent developments in technologies used for cancer control.
Synbiotic goat milk kefir improves health status in rats fed a high-fat and high-fructose diet

Abstract Background and Aim: Kefir, a natural probiotic containing bacteria and yeast, is a fermented milk product, whereas glucomannan from porang tuber (Amorphophallus oncophyllus) is prebiotic in vivo. Simvastatin is a potent lipid-lowering statin that can be utilized for pharmacological therapy in obesity. This study aimed to determine the effect of goat milk kefir supplemented with porang glucomannan (synbiotic kefir) and goat milk kefir without glucomannan (probiotic kefir) on blood glucose, hemoglobin A1c (HbA1c), free fatty acids (FFAs), tumor necrosis factor-alpha (TNF-α), gene expression of peroxisome proliferator-activated receptor gamma (PPARg), and insulin-producing cells in rats fed a high-fat and high-fructose (HFHF) diet. Materials and Methods: Male Sprague-Dawley rats were divided into five dietary groups: (1) Normal control, (2) rats fed HFHF, (3) rats fed HFHF+probiotic kefir, (4) rats fed HFHF+synbiotic kefir, and (5) rats fed HFHF+simvastatin. All of these treatments were administered for 4 weeks. Results: There were no significant differences in plasma glucose levels in HFHF diet-fed rats before and after treatment. However, plasma HbA1c and TNF-α decreased, and FFAs were inhibited in rats after treatment with synbiotic kefir. Synbiotic kefir decreased the gene expression of PPARγ2 in HFHF diet-fed rats but did not affect the total number of islets of Langerhans and insulin-producing cells. Conclusion: Synbiotic kefir improved the health of rats fed an HFHF diet by decreasing HbA1c, TNF-α, and PPARγ2 gene expression and preventing an increase in FFAs.
Relative and Chronological Age in Successful Athletes at the World Taekwondo Championships (1997–2019): A Focus on the Behaviour of Multiple Medallists

The aims of this study were to investigate the relative and chronological age among taekwondo world medal winners (by gender, Olympic 4-year period, Olympic weight category; N = 740), and to study the behaviour of multiple medallists (N = 156) to monitor changes in weight categories and wins over time. The observed birth quartile distribution for the heavyweight category was significantly skewed (p = 0.01). Female athletes (22.2 ± 3.5 years) achieve success at a significantly younger age (p = 0.01) than their male counterparts (23.6 ± 3.3 years). In the weight categories, female flyweights were significantly younger than those welterweights (p = 0.03) and heavyweight (p = 0.01); female featherweights were significantly younger than those heavyweights (p = 0.03). Male flyweights and featherweights were significantly younger than those welterweights and heavyweights (p = 0.01). When a taekwondo athlete won a medal several times, he/she did so within the same Olympic weight category group and won two medals in his/her career (p = 0.01). Multiple medallists of the lighter and heavier groups did not differ in the number of medals won but in the time span in which they won medals (p = 0.02). The resources deployed by stakeholders to achieve success in these competitions highlight an extremely competitive environment. In this sense, the information provided by this study can be relevant and translated into key elements.
Improvement of the Electrical-Mechanical Performance of Epoxy/Graphite Composites Based on the Effects of Particle Size and Curing Conditions

This study aims to improve the electrical-mechanical performance of traditional epoxy/graphite composites for engineering applications. The improvement in the properties of these composites depended on the incorporation of different sizes of graphite particles of the same type and controlling their curing process conditions. The thermal properties and microstructural changes were also characterized. A maximum in-plane electrical conductivity value of approximately 23 S/cm was reported for composites containing 80 wt. % G with a particle size of 150 µm. The effect of combining large and small G particles increased this value to approximately 32 S/cm by replacing the large particle size with 10 wt. % smaller particles (75 µm). A further increase in the electrical conductivity to approximately 50 S/cm was achieved due to the increase in curing temperature and time. Increasing the curing temperature or time also had a crucial role in improving the tensile strength of the composites and a tensile strength of ~19 MPa was reported using a system of multiple filler particle sizes processed at the highest curing temperature and time compared to ~9 MPa for epoxy/G150 at 80 wt. %. TGA analysis showed that the composites are thermally stable, and stability was improved by the addition of filler to the resin. A slight difference in the degraded weights and the glass transition temperatures between composites of different multiple filler particle sizes was also observed from the TGA and DSC results.
Clinical Update on Patient-Controlled Analgesia for Acute Postoperative Pain

Patient-controlled analgesia (PCA) is an effective method for controlling acute pain, including postoperative pain in adults and in children from five years of age, pain resulting from labor, trauma, or other medical situations, or chronic and malignant pain. The treatment consists of a mini-computer-controlled infusion pump permitting the administration of on-demand, continuous, or combined doses of analgesic (mainly opioid) variations in response to therapy, which allows pain to be significantly controlled. Intravenous (IV)-PCA minimizes individual pharmacodynamics and pharmacokinetic differences and is widely accepted as a reference method for mild or severe postoperative pain. IV-PCA is the most studied route of PCA; other delivery methods have been extensively reported in the literature. In addition, IV-PCA usually voids the gap between pain sensation and analgesic administration, permitting better recovery and fewer side effects. The most commonly observed complications are nausea and vomiting, pruritus, respiratory depression, sedation, confusion and urinary retention. However, human factors such as pharmacy preparation and device programming can also be involved in the occurrence of these complications, while device failure is much less of an issue.
Understanding the perceptions of low-income American working mothers in rural areas: exploratory analysis of relative care

ABSTRACT Informal childcare has a significant impact on the economic and social conditions of low-income families. However, as opposed to formal childcare, there is a lack of studies about relative care and its impact on working mothers. This study used the extended ethnographic comparative case method and analytical induction methodology to analyze in-depth interviews of 18 American females selected by purposive and convenient sampling: nine low-income working mothers living in a rural Midwestern area and another nine relatives who provided childcare. Low-income working mothers selected relative care because of children’s safety, the trustworthiness of caretakers, doubt in the quality of daycare, and relative care’s affordability. All mothers were satisfied with the activities offered by relative care. Outcomes supported that relative care helped mothers’ psychological, emotional, and economic well-being. The results of the caretakers were mixed. While some relatives addressed their complete happiness, others stated that providing care reduced their time and resources. Social workers need to understand the functions of extended family networks in rural areas, which have limited resources. The U.S. government should consider providing financial incentives for relatives who spend their time and energy assisting working mothers, as well as childcare subsidies for low-income families who rely on relative care.
NSAIDs and Cancer Resolution: New Paradigms beyond Cyclooxygenase

Acute inflammation or resolved inflammation is an adaptive host defense mechanism and is self-limiting, which returns the body to a state of homeostasis. However, unresolved, uncontrolled, or chronic inflammation may lead to various maladies, including cancer. Important evidence that links inflammation and cancer is that nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, reduce the risk and mortality from many cancers. The fact that NSAIDs inhibit the eicosanoid pathway prompted mechanistic drug developmental work focusing on cyclooxygenase (COX) and its products. The increased prostaglandin E2 levels and the overexpression of COX-2 in the colon and many other cancers provided the rationale for clinical trials with COX-2 inhibitors for cancer prevention or treatment. However, NSAIDs do not require the presence of COX-2 to prevent cancer. In this review, we highlight the effects of NSAIDs and selective COX-2 inhibitors (COXIBs) on targets beyond COX-2 that have shown to be important against many cancers. Finally, we hone in on specialized pro-resolving mediators (SPMs) that are biosynthesized locally and, in a time, -dependent manner to promote the resolution of inflammation and subsequent tissue healing. Different classes of SPMs are reviewed, highlighting aspirin’s potential in triggering the production of these resolution-promoting mediators (resolvins, lipoxins, protectins, and maresins), which show promise in inhibiting cancer growth and metastasis.
A correlative study of sella turcica bridging and dental anomalies related to size, shape, structure, number and eruption of teeth

OBJECTIVE: The main objective of this study is to get a wider and clearer idea about the relationship between sella turcica bridging and the type of dental anomalies related to size, shape, number, structure and eruption of teeth. MATERIALS AND METHODS: For the present study, 50 pretreatment lateral cephalometric radiographs showing complete sella turcica bridging were retrieved from the 500 existing case records of patients. The control group consisted of 50 pretreatment lateral cephalograms without sella turcica bridging retrieved from the same case records by using simple random sampling. After collection of the samples, retrospective study was performed with the analysis of patient records to assess any associated dental anomaly in patients with sella turcica bridging and patients without sella turcica bridging. Shafer's classification of morphological variations in size, shape, structure, number and eruption of teeth was used to analyze and group the dental anomalies. RESULTS: The incidence of dental anomalies related to number and size of teeth was found to be higher in cases with sella turcica bridging. CONCLUSION: Lateral cephalogram is used by orthodontist routinely for diagnosis and treatment planning; it can be used as a prediction tool for dental anomalies as well. Early detection of skeletal anomalies can be used to forecast the presence of dental anomalies later in life, which will help the clinician to adopt preventive measures.
Is audio a mandatory component of multimedia distraction for reduction of pain and anxiety of pediatric dental patients? A split-mouth crossover randomized controlled clinical trial

Background: Control of pain, fear, and anxiety of pediatric dental patients is a common concern for the parents and dental clinicians. This study aimed to compare the efficacy of audiovisual distraction (AVD) and mute-video distraction (MVD) for reduction of pain and anxiety of pediatric dental patients. Materials and Methods: This randomized split-mouth crossover clinical trial evaluated 60 systemically healthy children between 4 and 7 years requiring bilateral pulpotomy of primary maxillary first molars. The samples were randomly divided into 6 groups based on the distraction technique and sequence of its receipt: (I) control-AVD, (II) AVD-control, (III) control-MVD, (IV) MVD-control, (V) AVD-MVD, and (VI) MVD-AVD and were treated. The severity of pain and anxiety of patients during anesthetic injection was measured using physiological (pulse rate [PR]), sound, eyes, and motor (SEM) and faces pain rating (FPR) scales. Data were compared between Groups 1 and 2, 3 and 4, and 5 and 6 using crossover clinical trial analysis (P = 0.05). Results: The increase in PR and the mean FPR and SEM scales during anesthetic injection was significantly smaller in AVD than MVD (P < 0.05). No significant difference was noted between MVD and control technique regarding PR and mean FPR or SEM (P = 1.00). Conclusion: It appears that MVD has no significant efficacy for reduction of pain and anxiety of pediatric dental patients. AVD, however, can effectively decrease the pain and anxiety of pediatric dental patients during anesthetic injection.
Automating the Calibration of Visible Light Positioning Systems

Visible light positioning is one of the most popular technologies used for indoor positioning research. Like many other technologies, a calibration procedure is required before the system can be used. More specifically, the location and identity of each light source need to be determined. These parameters are often measured manually, which can be a labour-intensive and error-prone process. Previous work proposed the use of a mobile robot for data collection. However, this robot still needed to be steered by a human operator. In this work, we significantly improve the efficiency of calibration by proposing two novel methods that allow the robot to autonomously collect the required calibration data. In postprocessing, the necessary system parameters can be calculated from these data. The first novel method will be referred to as semi-autonomous calibration, and requires some prior knowledge of the LED locations and a map of the environment. The second, fully-autonomous calibration procedure requires no prior knowledge. Simulation results show that the two novel methods are both more accurate than manual steering. Fully autonomous calibration requires approximately the same amount of time to complete, whereas semi-autonomous calibration is significantly faster.
DNS of the spatiotemporal evolution of the vorticity in (pure) mode B of a circular cylinder’s wake

In the present paper, the spatio-temporal evolution of the vorticity field in the second wake instability, i.e. (pure) mode B is investigated to understand the wake vortex dynamics and sign relationships among the three vorticity components. Direct numerical simulation of the flow past a circular cylinder in the three-dimensional (3D) wake transition is performed, typically at a Reynolds number of 300. According to the time histories of fluid forces and frequency analysis, three different stages are identified. In the fully developed wake (FDW), the spanwise vortex core is almost two-dimensional, while the vortex braid is 3D due to the dominant streamwise interaction. However, streamwise and vertical vorticities owing to the intrinsic 3D instability are already generated first on cylinder surfaces early in the computational transition (CT). The evolution of additional vorticities with the same features as mode B shows that (pure) mode B could already be formed in the late CT. In the FDW, a special sign symmetry of these additional vorticities on the rear surface is observed, which is exactly opposite to that in (pure) mode B. Similarly, the two sign laws found in (pure) mode A are also verified in three typical regions, independent of the Reynolds number, for (pure) mode B. Particularly, the mechanism for the physical origin of streamwise and vertical vortices in the shear layers is the vortex generation on the wall first and then dominant vortex induction just near the wall. The entire process of the formation and shedding of vortices with three components of vorticity is first and completely illustrated. Other characteristics of the evolution of mode B are presented in detail.
NGSEP 4: Efficient and Accurate Identification of Orthogroups and Whole-Genome Alignment

Whole-genome alignment allows researchers to understand the genomic structure and variations among the genomes. Approaches based on direct pairwise comparisons of DNA sequences require large computational capacities. As a consequence, pipelines combining tools for orthologous gene identification and synteny have been developed. In this manuscript, we present the latest functionalities implemented in NGSEP 4, to identify orthogroups and perform whole genome alignments. NGSEP implements functionalities for identification of clusters of homologus genes, synteny analysis and whole genome alignment, and visualization. Our results showed that the NGSEP algorithm for ortholog identification has competitive accuracy and better efficiency in comparison to commonly used tools. The implementation also includes a visualization of the whole genome alignment based on synteny of the orthogroups that were identified, and a reconstruction of the pangenome based on frequencies of the orthogroups among the genomes. Finally, our software includes a new graphical user interface. We expect that these new developments will be very useful for several studies in evolutionary biology and population genomics.