Miracle-dz/UniFAR-FTUs huggingface dataset:
Russian heritage language development in narrative contexts: Evidence from pre- and primary-school children in Norway, Germany, and the UK

The present study aims at obtaining a comprehensive picture of language development in Russian heritage language (RHL) by bringing together evidence from previous investigations focusing on morphosyntax and global accent as well as from a newly conducted analysis of a less-studied domain–lexical development. Our investigation is based on a narrative sample of 143 pre- and primary-school bilinguals acquiring RHL in Norway, Germany, and the United Kingdom. We performed a multiple-way analysis of lexical production in RHL across the different national contexts, across both languages (heritage and societal), also comparing bilinguals and monolinguals. The results revealed a clear and steady increase with age in narrative length and lexical diversity for all bilingual groups in both of their languages. The variation in lexical productivity as well as the differences between the bilingual groups and between bilinguals and monolinguals were attributed to input factors with language exposure in the home and age of starting preschool as the major predictors. We conclude that, overall, the results from lexical, grammatical, and phonological acquisition in RHL support the view that having longer exclusive or uninterrupted exposure to a heritage language in early childhood is beneficial for its development across domains.
The mediating role of incentives in association between leadership attention and self-perceived continuous improvement in infection prevention and control among medical staff: A cross-sectional survey

Objectives Promoting improvement in Infection Prevention and Control (IPC) is an important part of improving the quality of care. The influence of leadership attention and incentives on the self-perceived continuous improvement in IPC has drawn a lot of attention, but relevant academic research is still lacking. The objective of this study is to explore the effect of leadership attention on self-perceived continuous improvement in IPC among medical staff and its underlying mechanisms. Method The 3,512 medical staff from 239 health facilities in Hubei, China, were surveyed online during September 2020. Data on leadership attention, incentives, and improvement in Infection Prevention and Control were collected using self-administered questionnaires. Correlation analysis was used to analyze the relationship between leadership attention, incentives, and improvement in Infection Prevention and Control. Amos 24.0 was used to analyze the mediating role. Results The scores of leadership attention, incentives and self-perceived continuous improvement in Infection Prevention and Control were all high. The score of leadership attention was the highest (4.67 ± 0.59), followed by self-perceived continuous improvement (4.62 ± 0.59) and incentives in Infection Prevention and Control (4.12 ± 0.83). Leadership attention positively affected self-perceived continuous improvement in Infection Prevention and Control (β = 0.85, 95% CI = [0.83, 0.87]). Moreover, incentives partially mediated the effect of leadership attention on self-perceived continuous improvement in Infection Prevention and Control among medical staff (β = 0.13, 95% CI = [0.12, 0.15]). Conclusion Leadership attention positively affects self-perceived continuous improvement in Infection Prevention and Control among medical staff, and incentives mediates this relationship. The present study has valuable implications for self-perceived continuous improvement in Infection Prevention and Control from the perspective of leadership attention and incentives.
New insights on the cardiovascular effects of IGF-1

Introduction Cardiovascular (CV) disorders are steadily increasing, making them the world’s most prevalent health issue. New research highlights the importance of insulin-like growth factor 1 (IGF-1) for maintaining CV health Methods We searched PubMed and MEDLINE for English and non-English articles with English abstracts published between 1957 (when the first report on IGF-1 identification was published) and 2022. The top search terms were: IGF-1, cardiovascular disease, IGF-1 receptors, IGF-1 and microRNAs, therapeutic interventions with IGF-1, IGF-1 and diabetes, IGF-1 and cardiovascular disease. The search retrieved original peer-reviewed articles, which were further analyzed, focusing on the role of IGF-1 in pathophysiological conditions. We specifically focused on including the most recent findings published in the past five years. Results IGF-1, an anabolic growth factor, regulates cell division, proliferation, and survival. In addition to its well-known growth-promoting and metabolic effects, there is mounting evidence that IGF-1 plays a specialized role in the complex activities that underpin CV function. IGF-1 promotes cardiac development and improves cardiac output, stroke volume, contractility, and ejection fraction. Furthermore, IGF-1 mediates many growth hormones (GH) actions. IGF-1 stimulates contractility and tissue remodeling in humans to improve heart function after myocardial infarction. IGF-1 also improves the lipid profile, lowers insulin levels, increases insulin sensitivity, and promotes glucose metabolism. These findings point to the intriguing medicinal potential of IGF-1. Human studies associate low serum levels of free or total IGF-1 with an increased risk of CV and cerebrovascular illness. Extensive human trials are being conducted to investigate the therapeutic efficacy and outcomes of IGF-1-related therapy. Discussion We anticipate the development of novel IGF-1-related therapy with minimal side effects. This review discusses recent findings on the role of IGF-1 in the cardiovascular (CVD) system, including both normal and pathological conditions. We also discuss progress in therapeutic interventions aimed at targeting the IGF axis and provide insights into the epigenetic regulation of IGF-1 mediated by microRNAs.
Editorial: Women in science: Pulmonary rehabilitation

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Determinants of arterial elastic function in middle-aged and elderly people: A population-based cross-sectional study from a low-income population in China

Background Arterial stiffness is closely associated with the occurrence of many cardiovascular and cerebrovascular diseases. However, the risk factors and mechanisms related to arterial stiffness development have only been partially elucidated. We aimed to describe arterial elastic function and its influencing factors in middle-aged and elderly people in rural China. Methods This was a cross-sectional study conducted among residents, aged ≥45 years, of Tianjin, China, between April and July 2015. Data regarding participant demographics, medical history, lifestyle, and physical examination results were collected and assessed the association with arterial elastic function using linear regression. Results Of the 3,519 participants, 1,457 were male (41.4%). Brachial artery distensibility (BAD) decreased by 0.5%/mmHg with every 10-year increment in age. The mean BAD value was 0.864%/mmHg lower in women than in men. With each unit increase in mean arterial pressure, the BAD decreased by 0.042%/mmHg. In patients with hypertension or diabetes, the BAD decreased by 0.726 and 0.183%/mmHg, respectively, compared with those without hypertension or diabetes. For each unit increase in triglyceride (TG) level, the mean BAD increased by 0.043%/mmHg. With each increase in body mass index (BMI) category, the BAD increased by 0.113%/mmHg. Brachial artery compliance (BAC) decreased by 0.007 ml/mmHg with each 10-year increase in age, and brachial artery resistance (BAR) increased by 30.237 dyn s–1 cm–5. The mean BAC in women was 0.036 ml/mmHg lower and the mean BAR was 155.231 dyn s–1 cm–5 higher in women than in men. In individuals with hypertension, the mean BAC decreased by 0.009 ml/mmHg and the mean BAR increased by 26.169 dyn s–1 cm–5. With each increase in BMI category, the mean BAC increased by 0.005 ml/mmHg and the mean BAR decreased by 31.345 dyn s–1 cm–5. For each unit increase in TG level, the mean BAC increased by 0.001 ml/mmHg. Conclusion These findings indicate that age, sex, mean arterial pressure, BMI, diabetes, hypertension, and TG level are independently associated with the components of peripheral arterial elasticity. Understanding the factors influencing arterial stiffness is important for developing interventions to minimize arterial aging and cardiovascular and cerebrovascular diseases caused by arterial aging.
Analytical validation and implementation of a pan cancer next-generation sequencing panel, CANSeqTMKids for molecular profiling of childhood malignancies

Next-Generation Sequencing (NGS) allows rapid analysis of multiple genes for the detection of clinically actionable variants. This study reports the analytical validation of a targeted pan cancer NGS panel CANSeqTMKids for molecular profiling of childhood malignancies. Analytical validation included DNA and RNA extracted from de-identified clinical specimens including formalin fixed paraffin embedded (FFPE) tissue, bone marrow and whole blood as well as commercially available reference materials. The DNA component of the panel evaluates 130 genes for the detection of single nucleotide variants (SNVs), Insertion and Deletions (INDELs), and 91 genes for fusion variants associated with childhood malignancies. Conditions were optimized to use as low as 20% neoplastic content with 5 ng of nucleic acid input. Evaluation of the data determined greater than 99% accuracy, sensitivity, repeatability, and reproducibility. The limit of detection was established to be 5% allele fraction for SNVs and INDELs, 5 copies for gene amplifications and 1,100 reads for gene fusions. Assay efficiency was improved by automation of library preparation. In conclusion, the CANSeqTMKids allows for the comprehensive molecular profiling of childhood malignancies from different specimen sources with high quality and fast turnaround time.
Rethinking 1D convolution for lightweight semantic segmentation

Lightweight semantic segmentation promotes the application of semantic segmentation in tiny devices. The existing lightweight semantic segmentation network (LSNet) has the problems of low precision and a large number of parameters. In response to the above problems, we designed a full 1D convolutional LSNet. The tremendous success of this network is attributed to the following three modules: 1D multi-layer space module (1D-MS), 1D multi-layer channel module (1D-MC), and flow alignment module (FA). The 1D-MS and the 1D-MC add global feature extraction operations based on the multi-layer perceptron (MLP) idea. This module uses 1D convolutional coding, which is more flexible than MLP. It increases the global information operation, improving features’ coding ability. The FA module fuses high-level and low-level semantic information, which solves the problem of precision loss caused by the misalignment of features. We designed a 1D-mixer encoder based on the transformer structure. It performed fusion encoding of the feature space information extracted by the 1D-MS module and the channel information extracted by the 1D-MC module. 1D-mixer obtains high-quality encoded features with very few parameters, which is the key to the network’s success. The attention pyramid with FA (AP-FA) uses an AP to decode features and adds a FA module to solve the problem of feature misalignment. Our network requires no pre-training and only needs a 1080Ti GPU for training. It achieved 72.6 mIoU and 95.6 FPS on the Cityscapes dataset and 70.5 mIoU and 122 FPS on the CamVid dataset. We ported the network trained on the ADE2K dataset to mobile devices, and the latency of 224 ms proves the application value of the network on mobile devices. The results on the three datasets prove that the network generalization ability we designed is powerful. Compared to state-of-the-art lightweight semantic segmentation algorithms, our designed network achieves the best balance between segmentation accuracy and parameters. The parameters of LSNet are only 0.62 M, which is currently the network with the highest segmentation accuracy within 1 M parameters.
The impact of environment-friendly short videos on consumers’ low-carbon tourism behavioral intention: A communicative ecology theory perspective

As key participants in tourism activities, the tourists have an important role in the carbon emissions. Therefore, it is essential to identify the key elements that can arouse consumers’ low-carbon tourism behavioral intention; this has become an important topic for the academic community. However, to the best of my knowledge, most studies have explored the process of formation of consumers’ low-carbon tourism behavioral intention from the cognitive or emotional perspective, and have seldom paid attention to the communication perspective. As a result, the interpretation and prediction of consumers’ low-carbon tourism behavioral intention is limited. Based on the framework of communicative ecology theory (CET) and stimulus-organism-response theory (SOR), our study constructs an integrated model of the relationship between environment-friendly short video experience and consumers’ low-carbon tourism behavioral intention at the technological, content and social levels, introduces emotional elements such as empathy with nature and perceived environmental responsibility. Structural equation model and bootstrap method were employed for analyzing the data. Results revealed that the presence and perception of environmental education are the cognitive factors that impact consumers’ low-carbon tourism behavioral intention; these can effectively stimulate consumers’ low-carbon tourism behavioral intention. Empathy with nature and perceived environmental responsibility are the emotional factors that impact consumers’ low-carbon tourism behavior; they play significant mediating roles between environment-friendly short video experience (presence, perception of environmental education, online interaction) and consumers’ low-carbon tourism behavioral intention. On the one hand, the research conclusions enrich the perspective and content of the research on consumers’ low-carbon tourism behavioral intention and its influencing mechanism; on the other hand, they acquaint with the practical significance of implementing environmental education via the emerging communication modes such as short videos, improve consumers’ awareness of their environmental responsibility, and promote environmental governance and sustainable development of tourist destinations.
Impacts of wild boars on local livelihoods in rural communities: A case study of mountainous areas in southeast China

Wild boar (Sus scrofa) seriously threatens agricultural production and rural livelihoods worldwide. Human-wild boar conflict has become an important research topic. We investigated the impact of wild boars on local livelihoods and rural community’s responses to the impact, based on a case study in Fu’an City, Fujian Province, Southeast China. We conducted a questionnaire survey of 152 rural households in six villages of Fu’an City. Results demonstrated that the overall impact of wild boars on livelihoods was significant; however, there was impact heterogeneity depending on the mentioned factors. The impact lied on the scale of agricultural output value and the extent of livelihood dependency on susceptible crops. Different impacts resulted in discrepant countermeasures of rural households in dealing with wild boars. The magnitude of economic losses caused by wild boars to a great extent determined the selection of prevention measures. Rural households with more economic losses tend to adopt costly and effective prevention measures, such as fencing and human guarding. Recommendations were put forward to address the human-wild boar conflicts in China.
Implementation of open dialogue in Germany: Efforts, challenges, and obstacles

Purpose The Open Dialogue (OD) approach has been implemented in different countries worldwide. OD not only depends on therapeutic principles but also requires a distinct set of structural changes that may impede its full implementation. In Germany, OD is currently practiced in different mental health care settings across the country. Yet, full implementation of OD principles is limited due to the extreme structural and financial fragmentation of the German mental health care system. With this as a background, the aim of this study was to investigate the efforts, challenges and obstacles of OD implementation in Germany. Methods This article presents the German results from the international HOPEnDIALOGUE survey, supplemented with expert interview data. Thirty eight teams currently providing OD took part in the survey. Sixteen expert interviews were carried out with stakeholders from various care settings. Survey data were analyzed descriptively and the qualitative data were evaluated using a thematic analysis approach. Results While having to adapt to the fragmented German health care system, OD has been mainly implemented from outpatient service providers and stand-alone services. About half of the teams implemented OD under the conditions of cross-sectoral model contracts and, thus, are considerably limited when it comes to OD implementation. Altogether, OD is not implemented to its full extent in each of the institutions surveyed. Similarly, the expert interviews revealed various challenges that mainly relate to the realization of OD’s structural principles, whereas the implementation of its therapeutic benefits remains less affected. However, these challenges have managed to lead to great commitment by single teams and a certain level of implementation of OD-related concepts. Conclusion OD in Germany can currently only be fully implemented under the cross-sectoral care model contract system that is often temporary, thus significantly hindering its continuous development. Any evaluation of OD’s effectiveness in Germany thus needs to take into account the fragmented nature of the country’s health care system and control for the multiple barriers that impede implementation. Reforms of the German health care system are also urgently needed to create more favorable conditions for the implementation of OD.
Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity

Amblyomin-X is a Kunitz-type FXa inhibitor identified through the transcriptome analysis of the salivary gland from Amblyomma sculptum tick. This protein consists of two domains of equivalent size, triggers apoptosis in different tumor cell lines, and promotes regression of tumor growth, and reduction of metastasis. To study the structural properties and functional roles of the N-terminal (N-ter) and C-terminal (C-ter) domains of Amblyomin-X, we synthesized them by solid-phase peptide synthesis, solved the X-Ray crystallographic structure of the N-ter domain, confirming its Kunitz-type signature, and studied their biological properties. We show here that the C-ter domain is responsible for the uptake of Amblyomin-X by tumor cells and highlight the ability of this domain to deliver intracellular cargo by the strong enhancement of the intracellular detection of molecules with low cellular-uptake efficiency (p15) after their coupling with the C-ter domain. In contrast, the N-ter Kunitz domain of Amblyomin-X is not capable of crossing through the cell membrane but is associated with tumor cell cytotoxicity when it is microinjected into the cells or fused to TAT cell-penetrating peptide. Additionally, we identify the minimum length C-terminal domain named F2C able to enter in the SK-MEL-28 cells and induces dynein chains gene expression modulation, a molecular motor that plays a role in the uptake and intracellular trafficking of Amblyomin-X.
Becoming agroecologists: A pedagogical model to support graduate student learning and practice

Introduction Agroecology has multiple beginnings in diverse knowledge systems, growing practices, and social movements which, as a whole, seek systemic transformation to build just food system futures. As graduate students, we have been inspired by agroecological movements and practitioners and endeavored to build our knowledge and capacities as agroecologists. Over the course of seven years, we have worked collectively with an evolving cohort to build relationships, understand critical lineages, and practice participatory processes that we found necessary for our development as agroecologists at the University of Minnesota-Twin Cities. Building on this work, we sought to refine an emergent understanding of the necessary components of an agroecological pedagogy. Methods We thus hosted a series of workshops in summer 2019 to facilitate collective reflection and development of a pedagogy, which we further refined through collective autoethnography. Results The resulting model contains five key components: a cohort at the heart of the model to facilitate collective learning; critical inquiry as the foundation of knowledge production; relational centering as the basis for building and maintaining care-based relationships with self and others; participatory practice as a space for taking action through and within relationships; and situated knowledge to recognize the unique and incomplete knowledge that each individual brings to their work. Discussion We imagine this model as the basis for a dedicated agroecology graduate program, and we close by sharing ongoing implementation efforts, key areas for further development, and our hopes for continued integration with broader movements. Ultimately, we have experienced this process as a transformational agroecological space and hope others are inspired to adapt, imagine, and enact the process, model, and principles in their own places and communities.
Amoxicillin-docosahexaenoic acid encapsulated chitosan-alginate nanoparticles as a delivery system with enhanced biocidal activities against Helicobacter pylori and improved ulcer healing

Encapsulation of amoxicillin (AMX) for drug delivery against Helicobacter pylori infection and aspirin-induced ulcers in rat’s stomachs was performed using docosahexaenoic acid (DHA)-loaded chitosan/alginate (CA) nanoparticles (NPs) developed by ionotropic gelation method. The physicochemical analyses of the composite NPs were performed by scanning electron microscopy, Fourier transform infrared spectroscopy, zeta potential, X-ray diffraction, and atomic force microscopy. The encapsulation efficiency of AMX was increased to 76% by incorporating DHA, which resulted in a reduction in the particle size. The formed CA-DHA-AMX NPs effectively adhered to the bacteria and rat gastric mucosa. Their antibacterial properties were more potent than those of the single AMX and CA-DHA NPs as demonstrated by the in vivo assay. The composite NPs attained higher mucoadhesive potential during food intake than during fasting (p = 0.029). At 10 and 20 mg/kg AMX, the CA-AMX-DHA showed more potent activities against H. pylori than the CA-AMX, CA-DHA, and single AMX. The in vivo study showed that the effective dose of AMX was lower when DHA was included, indicating better drug delivery and stability of the encapsulated AMX. Both mucosal thickening and ulcer index were significantly higher in the groups receiving CA-DHA-AMX than in the groups receiving CA-AMX and single AMX. The presence of DHA declines the pro-inflammatory cytokines including IL-1β, IL-6, and IL-17A. The synergistic effects of AMX and the CA-DHA formulation increased the biocidal activities against H. pylori infection and improved ulcer healing properties.