Miracle-dz/UniFAR-FTUs huggingface dataset:
From Ideal to Real: Attachment Orientations Guide Preference for an Autonomous Leadership Style

Autonomy is a key characteristic of attachment relations that varies as a function of attachment orientations and is also a key personality characteristic of leadership perceptions. In the presented research, we reasoned that the relationship between attachment and autonomy-related preference for specific leaders and leadership behavior would be a function of individuals’ insecure attachment strategies. We tested our hypotheses in two studies. Study 1 used Multiple Indicators Multiple Causes (MIMIC) modeling to test expectations based on a cross-sectional design, while Study 2 utilized a vignette-based experimental design. We find that anxious individuals attributed less positive evaluations to an autonomous leadership style (Study 1), while avoidant persons attributed higher leader competence to an autonomous leader description (Study 2). Compared to less anxious participants, highly anxious participants attributed lower competence to the autonomous leader description. By examining how individual differences in attachment orientations can indirectly influence the ideal leader categorization process, the present set of studies lends support to the importance of attachment orientations and related working models in leader perception and contribute to the literature on leader-follower fit. Using a survey and experimental approach, we examine how followers’ attachment schemas can shape the leader influence process, specifically concerning a preference for an autonomous leadership style.
The Dynamic Instability of the Aneuploid Genome

Proper partitioning of replicated sister chromatids at each mitosis is crucial for maintaining cell homeostasis. Errors in this process lead to aneuploidy, a condition in which daughter cells harbor genome imbalances. Importantly, aneuploid cells often experience DNA damage, which in turn could drive genome instability. This might be the product of DNA damage accumulation in micronuclei and/or a consequence of aneuploidy-induced replication stress in S-phase. Although high levels of genome instability are associated with cell cycle arrest, they can also confer a proliferative advantage in some circumstances and fuel tumor growth. Here, we review the main consequences of chromosome segregation errors on genome stability, with a special focus on the bidirectional relationship between aneuploidy and DNA damage. Also, we discuss recent findings showing how increased genome instability can provide a proliferation improvement under specific conditions, including chemotherapeutic treatments.
Extracellular Matrix in Aging Aorta

The aging population is booming all over the world and arterial aging causes various age-associated pathologies such as cardiovascular diseases (CVDs). The aorta is the largest elastic artery, and transforms pulsatile flow generated by the left ventricle into steady flow to maintain circulation in distal tissues and organs. Age-associated structural and functional changes in the aortic wall such as dilation, tortuousness, stiffening and losing elasticity hamper stable peripheral circulation, lead to tissue and organ dysfunctions in aged people. The extracellular matrix (ECM) is a three-dimensional network of macromolecules produced by resident cells. The composition and organization of key ECM components determine the structure-function relationships of the aorta and therefore maintaining their homeostasis is critical for a healthy performance. Age-associated remodeling of the ECM structural components, including fragmentation of elastic fibers and excessive deposition and crosslinking of collagens, is a hallmark of aging and leads to functional stiffening of the aorta. In this mini review, we discuss age-associated alterations of the ECM in the aortic wall and shed light on how understanding the mechanisms of aortic aging can lead to the development of efficient strategy for aortic pathologies and CVDs.
Small Semi-Fossorial Herbivores Affect the Allocation of Above- and Below-Ground Plant Biomass in Alpine Meadows

Small semi-fossorial herbivores can affect plant aboveground biomass (AGB) in grasslands and possibly alter the allocation of AGB and belowground biomass (BGB). In this study, plateau pika (Ochotona curzoniae) was used to investigate such effects at three alpine meadow sites on the Eastern Tibetan Plateau, where pairs of disturbed vs. undisturbed plots were randomly selected and sampled. We also explored the relationships between soil properties and BGB/AGB across the plots in the presence and absence of plateau pikas, respectively. We found that BGB and BGB/AGB were 11.40 and 8.20% lower in the presence of plateau pikas than in their absence, respectively. We also found that the BGB/AGB was positively related to soil moisture and soil total nitrogen (STN) in the absence of plateau pikas. In contrast, BGB/AGB was positively related to STN, soil organic carbon (SOC), soil carbon/nitrogen (C/N), and soil total phosphorus in the presence of plateau pikas. These factors indicated plateau pika disturbance increased AGB allocation. The relationship between AGB and BGB of alpine meadow plants to soil variables was also different between sites with and without plateau pika disturbance. In conclusion, small semi-fossorial herbivore disturbance is likely to alter grassland carbon stock and should be well controlled for sustainable conservation and management of alpine meadows on the Tibetan Plateau.
Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection

Uncontrolled severe acute respiratory syndrome-coronavirus (SARS-CoV)-2 infection is closely related to disorders of the innate immune and delayed adaptive immune systems. Dendritic cells (DCs) “bridge” innate immunity and adaptive immunity. DCs have important roles in defending against SARS-CoV-2 infection. In this review, we summarize the latest research concerning the role of DCs in SARS-CoV-2 infection. We focus on the complex interplay between DCs and SARS-CoV-2: pyroptosis-induced activation; activation of the renin–angiotensin–aldosterone system; and activation of dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin. We also discuss the decline in DC number, the impaired antigen-presentation capability, and the reduced production of type-I interferon of DCs in severe SARS-CoV-2 infection. In addition, we discuss the potential mechanisms for pathological activation of DCs to understand the pattern of SARS-CoV-2 infection. Lastly, we provide a brief overview of novel vaccination and immunotherapy strategies based on DC targeting to overcome SARS-CoV-2 infection.
Musicality and Age Interaction in Tone Development

Vocal pitch, which involves not only F0 but also multiple covarying acoustic cues is central to linguistic perception and production at various levels of prosodic structure. Recent studies on language development have shown that differences in learners' musicality affect the F0 cue development in perception of sentence-level intonation or in prosodic realization of focus. This study aims to contribute toward a fuller understanding of the effect of musicality on linguistic pitch development via a close investigation of the relationship between musicality, age, and lexical tone production covering both F0 and spectral cues in children. Forty-three native Mandarin-speaking children between the ages of 4 and 6 years are recruited to participate in both a semi-spontaneous tone production task and a musicality test. For each age (4, 5, and 6 years) and musicality (below or above the median score of each age group) group, the contrastivity of the four tones is evaluated by performing automatic tone classification using three sets of acoustic cues (F0, spectral cues, and both). It has been found that higher musicality is associated with higher contrastivity of the tones produced at the age of 4 and 5 years, but not at the age of 6 years. These results suggest that musicality promotes earlier development of tone production only in earlier stages of prosodic development; by the age of 6 years, the musicality advantage in tone production subsides.
Perioperative Propranolol Against Dental Anxiety: A Randomized Controlled Trial

Background Promising results from a trauma reactivation study on post-traumatic stress disorder suggest that propranolol is capable of attenuating symptoms of traumatically induced mental disorders by blocking memory reconsolidation. Methods A randomized, parallel, placebo-controlled, quadruple-blind trial was designed to determine the effectiveness of perioperative propranolol during exposure to dental extractions in reducing dental anxiety in patients with dental anxiety or dental phobia. Between November 2014 and December 2018, 52 patients with high levels of fear in anticipation of dental extractions who were referred to a department of oral and maxillofacial surgery for at least two tooth and/or molar removals with 1 month in between were included. On the first visit participants received either 120 mg of perioperative oral propranolol (n = 19) or placebo (n = 17), and a core fear memory was reactivated 1 h preoperatively. The primary outcome was change in severity of dental anxiety from baseline to 1-month follow-up, as indexed by the short version of the dental anxiety inventory (S-DAI). Secondary outcome measures were change in intra-operative state anxiety and specific phobia diagnoses. Results Linear mixed model (LMM) yielded no statistically significant difference in change of dental trait anxiety from baseline to 1-month follow-up between propranolol and placebo groups (Cohen's d = 0.23). S-DAI scores decreased in both study arms from baseline to follow-up (propranolol arm: from 32.1 [SD = 7.3] to 29.1 [SD = 8.8]; placebo arm: from 31.6 [SD = 7.5] to 27.1 [SD = 6.5]). Also, administering propranolol was not associated with a significant difference in change of intra-operative state anxiety or phobia diagnoses between groups over time. Conclusions The results do not concur with earlier findings regarding post-traumatic stress disorder, and suggest that individuals with traumatically induced fears or phobias do not benefit from the application of perioperative propranolol.
Cost-Benefit Trade-Offs of Aquatic Resource Exploitation in the Context of Hominin Evolution

While the exploitation of aquatic fauna and flora has been documented in several primate species to date, the evolutionary contexts and mechanisms behind the emergence of this behavior in both human and non-human primates remain largely overlooked. Yet, this issue is particularly important for our understanding of human evolution, as hominins represent not only the primate group with the highest degree of adaptedness to aquatic environments, but also the only group in which true coastal and maritime adaptations have evolved. As such, in the present study we review the available literature on primate foraging strategies related to the exploitation of aquatic resources and their putative associated cognitive operations. We propose that aquatic resource consumption in extant primates can be interpreted as a highly site-specific behavioral expression of a generic adaptive foraging decision-making process, emerging in sites at which the local cost-benefit trade-offs contextually favor aquatic over terrestrial foods. Within this framework, we discuss the potential impacts that the unique intensification of this behavior in hominins may have had on the evolution of the human brain and spatial ecology.
Past Negative Consequences of Unnecessary Delay as a Marker of Procrastination

Standard definitions of procrastination underscore the irrational nature of this habit, a critical criterion being that the procrastinating individual delays despite expecting to be worse off for the delay. However, an examination of more than 175 items in 18 procrastination scales reveals that they do not address such a forward-looking criterion. Consequently, scales run the risk of not separating maladaptive and irrational delays from other forms of delay. We propose that forward-looking considerations may not be the best way of operationalizing the irrationality involved in procrastination and argue that scales should instead focus on past negative consequences of unnecessary delay. We suggest a new scale to measure such procrastination-related negative consequences and demonstrate that this scale, used separately or combined with established procrastination scales, performs better in predicting negative states and correlates to procrastination than established scales. The new scale seems to be helpful in separating trivial forms of unnecessary delay from maladaptive forms and hence represents a potentially valuable tool in research and clinical/applied efforts.
High-Dimensional Analysis Reveals Distinct Endotypes in Patients With Idiopathic Inflammatory Myopathies

The idiopathic inflammatory myopathies (IIM) are a rare clinically heterogeneous group of conditions affecting the skin, muscle, joint, and lung in various combinations. While myositis specific autoantibodies are well described, we postulate that broader immune endotypes exist in IIM spanning B cell, T cell, and monocyte compartments. This study aims to identify immune endotypes through detailed immunophenotyping of peripheral blood mononuclear cells (PBMCs) in IIM patients compared to healthy controls. We collected PBMCs from 17 patients with a clinical diagnosis of inflammatory myositis and characterized the B, T, and myeloid cell subsets using mass cytometry by time of flight (CyTOF). Data were analyzed using a combination of the dimensionality reduction algorithm t-distributed stochastic neighbor embedding (t-SNE), cluster identification, characterization, and regression (CITRUS), and marker enrichment modeling (MEM); supervised biaxial gating validated populations identified by these methods to be differentially abundant between groups. Using these approaches, we identified shared immunologic features across all IIM patients, despite different clinical features, as well as two distinct immune endotypes. All IIM patients had decreased surface expression of RP105/CD180 on B cells and a reduction in circulating CD3+CXCR3+ subsets relative to healthy controls. One IIM endotype featured CXCR4 upregulation across all cellular compartments. The second endotype was hallmarked by an increased frequency of CD19+CD21loCD11c+ and CD3+CD4+PD1+ subsets. The experimental and analytical methods we describe here are broadly applicable to studying other immune-mediated diseases (e.g., autoimmunity, immunodeficiency) or protective immune responses (e.g., infection, vaccination).
Metabolite Profiling and Transcriptome Analyses Provide Insight Into Phenolic and Flavonoid Biosynthesis in the Nutshell of Macadamia Ternifolia

Macadamia ternifolia is a dynamic oil-producing nut crop in the world. However, the nutshell is frequently considered as a low-quality material. Further, its metabolic profile is still uncharacterized. In order to explore the industrial significance of the nutshell, this study performed metabolic and transcriptomic analyses at various developmental stages of the nutshell. The qualitative and quantitative metabolic data analysis identified 596 metabolic substances including several species of phenolic acids, flavonoids, lipids, organic acids, amino acids and derivatives, nucleotides and derivatives, alkaloids, lignans, coumarins, terpenoids, tannins, and others. However, phenolic acids and flavonoids were predominant, and their abundance levels were significantly altered across various developmental stages of the nutshell. Comparative transcriptome analysis revealed that the expression patterns of phenolic acid and flavonoid pathway related genes were significantly changed during the nutshell growth. In particular, the expression of phenylalanine ammonia-lyase, C4H, 4CL, CHS, CHI, F3H, and FLS had dynamic differences at the various developmental stages of the nutshell. Our integrative metabolomic and transcriptomic analyses identified the key metabolic substances and their abundance levels. We further discussed the regulatory mechanism of phenolic and flavonoid biosynthesis in the nutshell of M. ternifolia. Our results provide new insights into the biological profiles of the nutshell of M. ternifolia and help to elucidate the molecular mechanisms of phenolic and flavonoid biosynthesis in the nutshell of M. ternifolia.
Use of Electronic Auscultation in Full Personal Protective Equipment to Detect Ventilation Status in Selective Lung Ventilation: A Randomized Controlled Trial

Chest auscultation is the first procedure performed to detect endotracheal tube malpositioning but conventional stethoscopes do not conform to the personal protective equipment (PPE) protocol during the COVID-19 pandemic. This double-blinded randomized controlled trial evaluated the feasibility of using ear-contactless electronic stethoscope to identify endobronchial blocker established selective lung ventilation, simulating endobronchial intubation during thoracic surgery with full PPE. Conventional and electronic auscultation was performed without and with full PPE, respectively, of 50 patients with selective lung ventilation. The rates of correct ventilation status detection were 86 and 88% in the conventional and electronic auscultation groups (p = 1.00). Electronic auscultation revealed a positive predictive value of 87% (95% CI 77 to 93%), and a negative predictive value of 91% (95% CI 58 to 99%), comparable to the results for conventional auscultation. For detection of the true unilateral lung ventilation, the F1 score and the phi were 0.904 and 0.654, respectively for conventional auscultation; were 0.919 and 0.706, respectively for electronic auscultation. Furthermore, the user experience questionnaire revealed that the majority of participant anesthesiologists (90.5%) rated the audio quality of electronic lung sounds as comparable or superior to that of conventional acoustic lung sounds. In conclusion, electronic auscultation assessments of ventilation status as examined during thoracic surgery in full PPE were comparable in accuracy to corresponding conventional auscultation assessments made without PPE. Users reported satisfactory experience with the electronic stethoscope.
Tgfbr2 in Dental Pulp Cells Guides Neurite Outgrowth in Developing Teeth

Transforming growth factor β (TGFβ) plays an important role in tooth morphogenesis and mineralization. During postnatal development, the dental pulp (DP) mesenchyme secretes neurotrophic factors that guide trigeminal nerve fibers into and throughout the DP. This process is tightly linked with dentin formation and mineralization. Our laboratory established a mouse model in which Tgfbr2 was conditionally deleted in DP mesenchyme using an Osterix promoter-driven Cre recombinase (Tgfbr2 cko ). These mice survived postnatally with significant defects in bones and teeth, including reduced mineralization and short roots. Hematoxylin and eosin staining revealed reduced axon-like structures in the mutant mice. Reporter imaging demonstrated that Osterix-Cre activity within the tooth was active in the DP and derivatives, but not in neuronal afferents. Immunofluorescence staining for β3 tubulin (neuronal marker) was performed on serial cryosections from control and mutant molars on postnatal days 7 and 24 (P7, P24). Confocal imaging and pixel quantification demonstrated reduced innervation in Tgfbr2 cko first molars at both stages compared to controls, indicating that signals necessary to promote neurite outgrowth were disrupted by Tgfbr2 deletion. We performed mRNA-Sequence (RNA-Seq) and gene onotology analyses using RNA from the DP of P7 control and mutant mice to investigate the pathways involved in Tgfbr2-mediated tooth development. These analyses identified downregulation of several mineralization-related and neuronal genes in the Tgfbr2 cko DP compared to controls. Select gene expression patterns were confirmed by quantitative real-time PCR and immunofluorescence imaging. Lastly, trigeminal neurons were co-cultured atop Transwell filters overlying primary Tgfbr2 f/f DP cells. Tgfbr2 in the DP was deleted via Adenovirus-expressed Cre recombinase. Confocal imaging of axons through the filter pores showed increased axonal sprouting from neurons cultured with Tgfbr2-positive DP cells compared to neurons cultured alone. Axon sprouting was reduced when Tgfbr2 was knocked down in the DP cells. Immunofluorescence of dentin sialophosphoprotein in co-cultured DP cells confirmed reduced mineralization potential in cells with Tgfbr2 deletion. Both our proteomics and RNA-Seq analyses indicate that axonal guidance cues, particularly semaphorin signaling, were disrupted by Tgfbr2 deletion. Thus, Tgfbr2 in the DP mesenchyme appears to regulate differentiation and the cells’ ability to guide neurite outgrowth during tooth mineralization and innervation.
PEER-REVIEWED ARTICLE

Changes in color were evaluated for beech wood Fagus sylvatica L. , caused by a steaming process using either a mixture of saturated steam and air or saturated water steam in the temperature range: t = 95 °C to 125 °C for a duration of T = 3 h to 12 h. The initially light white-gray color of beech wood with a yellow tint darkened during the thermal treatment process. It changed to a pale pink-brown and then to dark brown color. According to the visible changes in the color of beech wood obtained by the thermal treatment process with the human eye, , a color scale was proposed as a means to categorize the severity of treatment. The color ranged from a pale pink-brown color to a dark brown-red color depending on the value of the total color difference ∆E*.
VEHICLE NUMBER PLATE DETECTION AND RECOGNITION USING DEEP LEARNING

Automatic License Plate recognition (ALPR) is an image processing technology which uses a number (license) plate to find the vehicle. The objective is to design an efficient authorized vehicle identification system by using the vehicle number/license plate. The system is implemented on the entrance for security control of a highly restricted area like military zones or areas around top government offices e.g., Parliament, Supreme Court etc. The developed system first detects the vehicle and then captures the vehicle image. Vehicle number plate region is extracted using the image segmentation in an image. Optical character recognition technique is used for character recognition. The resulting data is then used to compare with the records on a database to produce specific information like the vehicle owner, place of registration, address, etc. The system and its performance are tested on real images. It is seen from the experiment that the developed system successfully detects and recognizes the vehicle number plate on real images. Index Terms Data Processing, Number plate Detection, Character Recognition.
A comparative analysis of employee engagement of office-based and field- based employees with special reference to a sme in telecom sector

Employee engagement is considered as a recipe for organizational success. Engaged employees are enthusiastic and committed to the organization. Some organizations have employees working on the field as well as in office. In such cases it becomes pertinent to measure, compare and understand the difference in engagement levels of the employees. This study aims at establishing the difference in engagement levels among employee segments. It includes 83 employees drawn from both office-based and field-based categories in a Small and Medium Enterprise (SME) in telecom sector of India. This diagnostic and predictive study reveals that work, manager, culture and team-related factors drive engagement. It establishes that engagement is an outcome of interplay of these four factors. The paper recommends more customized engagement interventions and initiatives to be planned and introduced for specific employee segments to increase job satisfaction and their contribution to the organization.