Miracle-dz/UniFAR-FTUs huggingface dataset:
UPLC-Q–TOF–MS, network analysis, and molecular docking to investigate the effect and active ingredients of tea-seed oil against bacterial pathogens

Object: This research intended to probe the antibacterial effect and pharmacodynamic substances of Tea-Seed Oil (TSO) through the use of ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) analysis, network analysis, and molecular docking. Methods: The major chemical components in the methanol-extracted fractions of TSO were subjected to UPLC-Q-TOF-MS. Network pharmacology and molecular docking techniques were integrated to investigate the core components, targets, and potential mechanisms of action through which the TSO exert their antibacterial properties. To evaluate the inhibitory effects, the minimum inhibitory concentration and diameter of the bacteriostatic circle were calculated for the potential active ingredients and their equal ratios of combinatorial components (ERCC) against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. Moreover, the quantification of the active constituents within TSO was achieved through the utilization of high-performance liquid chromatography (HPLC). Results: The methanol-extracted fractions contained a total of 47 chemical components, predominantly consisting of unsaturated fatty acids and phenolic compounds. The network pharmacology analysis and molecular docking analysis revealed that various components, including gallocatechin, gallic acid, epigallocatechin, theophylline, chlorogenic acid, puerarin, and phlorizin, have the ability to interact with critical core targets such as serine/threonine protein kinase 1 (AKT1), epidermal growth factor receptor (EGFR), a monoclonal antibody to mitogen-activated protein kinase 14 (MAPK14), HSP90AA1, and estrogen receptor 1 (ESR1). Furthermore, these components can modulate the phosphatidylinositol-3-kinase protein kinase B (PI3K-AKT), estrogen, MAPK and interleukin 17 (IL-17) signaling pathways, hereby exerting antibacterial effects. In vitro validation trials have found that seven components, namely gallocatechin, gallic acid, epigallocatechin, theophylline, chlorogenic acid, puerarin, and phloretin, displayed substantial inhibitory effects on E. coli, S. aureus, P. aeruginosa, and C. albicans, and are typically present in tea oil, with a total content ranging from 15.87∼24.91 μg·g−1. Conclusion: The outcomes of this investigation possess the possibility to expand our knowledge base concerning the utilization of TSO, furnish a theoretical framework for the exploration of antibacterial drugs and cosmetics derived from inherently occurring TSO, and establish a robust groundwork for the advancement and implementations of TOS products within clinical settings.
The Relationship Between Unemployment and Economic Output: An Examination of The Okun Law For Turkey

Unemployment is the situation in which people who can work in the country and want to work at the current wage level cannot find a job. Unemployment includes only voluntary unemployment out of voluntary and unemployment situations. Unemployment is a problem that can not be solved in Turkey's economy. Governments have implemented various policies to find a solution to this problem. Unemployment and economic growth have been constantly explored. In this study, annual data for the period 1990-2019 were used. Regression analysis was performed to find the short-term coefficient with unemployment and growth data, which were found to be stable at the level according to the unit root test results. As a result of the regression analysis, it was seen that unemployment decreased by 0.07 per unit change for the short term. Okun's Law has reached the current results for Turkey. Suitable lag length for VAR model has been found to be 0 (zero). Looking at the Granger causality test, no causality relationship between variables was found. The relationship between unemployment and growth was tested by regression analysis. No causality between unemployment and growth has been found.
Right vs. left ventricular longitudinal strain for mortality prediction after transcatheter aortic valve implantation

Introduction This study aims at exploring biventricular remodelling and its implications for outcome in a representative patient cohort with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI). Methods and results Pre-interventional echocardiographic examinations of 100 patients with severe AS undergoing TAVI were assessed by speckle tracking echocardiography of both ventricles. Association with mortality was determined for right ventricular global longitudinal strain (RVGLS), RV free wall strain (RVFWS) and left ventricular global longitudinal strain (LVGLS). During a median follow-up of 1,367 [959–2,123] days, 33 patients (33%) died. RVGLS was lower in non-survivors [−13.9% (−16.4 to −12.9)] than survivors [−17.1% (−20.2 to −15.2); P = 0.001]. In contrast, LVGLS as well as the conventional parameters LV ejection fraction (LVEF) and RV fractional area change (RVFAC) did not differ (P = ns). Kaplan–Meier analyses indicated a reduced survival probability when RVGLS was below the −14.6% cutpoint (P < 0.001). Lower RVGLS was associated with higher mortality [HR 1.13 (95% CI 1.04–1.23); P = 0.003] independent of LVGLS, LVEF, RVFAC, and EuroSCORE II. Addition of RVGLS clearly improved the fitness of bivariable and multivariable models including LVGLS, LVEF, RVFAC, and EuroSCORE II with potential incremental value for mortality prediction. In contrast, LVGLS, LVEF, and RVFAC were not associated with mortality. Discussion In patients with severe AS undergoing TAVI, RVGLS but not LVGLS was reduced in non-survivors compared to survivors, differentiated non-survivors from survivors, was independently associated with mortality, and exhibited potential incremental value for outcome prediction. RVGLS appears to be more suitable than LVGLS for risk stratification in AS and timely valve replacement.
Quality aspects vs consumption values: What affects intention to book hotels in the post-Covid era?

Abstract The Covid-19 pandemic had affected the hospitality sector the most due to lockdowns and other government restrictions. As hotels are trying to recover from the losses suffered during the pandemic, hotels can prepare better strategies if they are able to understand the factors affecting customers’ intention to book hotels in the post-Covid era from the Service Quality (SERVQUAL) and Consumption Value Theory lens. Based on a multi-method study containing 33 qualitative interviews, 18274 online reviews and 311 survey responses, it was found that customers prefer ‘less-crowded clean hotels’ which follow Covid-related guidelines properly. The customer reviews about hotels revealed consumption values like, epistemic (“view”, “spacious”), functional (“food”, “location”), conditional (offers/discounts), and service qualities like, customer service (food quality, staff behavior, room cleanliness), and empathy (comfort, peacefulness). The quantitative analysis found that reliability, brand credibility, and brand loyalty affect customer’s hotel booking intentions. This multi-method study contributes to the existing literature on the values and quality aspects that affect customer behavior in the hospitality and tourism segment. Findings of this study will thus help managers to make better strategies by providing a better view of the consumption values and service quality aspects that affect customer’s hotel booking intention in post-pandemic era.
Intelligent Expert System for Diagnosing Faults and Assessing Quality of Power Transformer Insulation Oil by DGA Method

Accurate assessment of oil and fault diagnostics of electrical power transformer insulation for lifelong endurance are the key issues addressed in this research. The durability of a transformer is significantly determined by the quality of its insulation oil, which deteriorates over time due to temperature fluctuations and moisture content. Protecting transformers from potential failure through the early and precise diagnosis of faults and efficient assessment of oil quality during the actual conduct of the operation can avoid sizeable economic losses. The ANFIS Expert System that uses intelligent software plays an important role. The dissolved gas analysis (DGA) in oil is reliable for diagnosing faults and assessing insulation oil quality in transformers. Transformer power plant protection teams often suffer sudden breakdowns that lead to massive damage and huge financial losses. The oil in transformers must be appropriately treated to circumvent such failures. In this research, an ANFIS Expert System was used to diagnose faults and assess insulation oil status and quality in power transformers. by the Rogers ratio method depending on the DGA in oil, a suitable treatment was identified. The graphical user interface from the MATLAB environment was used and proven effective for fault diagnosis and oil quality evaluation. The training algorithm can assess oil quality according to the specifications of the IEEE standard C57-104 and the IEC standard 60599.
Implementation of real‐time hybrid simulation based on Python‐graphics processing unit computing

Real‐time hybrid simulation is a testing method that combines physical experiments and numerical simulations, which can increase the dimensions of experimental specimens and reduce the error of scaling testing. Currently, the maximum degrees of freedom of numerical models are 7000 in real time. To improve the scale of numerical simulation in real time, a testing framework based on Python and graphics processing unit was proposed in this paper. The maximum degrees of freedom of the numerical model exceeded 24,000 with the testing framework. The testing capacity of real‐time hybrid simulation was significantly improved by the graphics processing unit calculations.
Swimmers’ Effective Actions during the Backstroke Start Technique

The analysis of the external forces of swimming starts has revealed how swimmers propel themselves out of the block, but data should be properly interpreted to fully understand force-generation mechanisms. This study aimed to assess horizontal and vertical forces in the backstroke start based on swimmers’ structural and propulsive actions. Firstly, a simulated structural force was estimated by two transient backstroke-start inter-segmental realistic body positions: a maximally tucked position and an extended one (just before the hands-off and the take-off, respectively). Secondly, 10 competitive backstroke swimmers performed four 15 m maximal backstroke starts with the external forces estimated. Thirdly, the simulated structural force was subtracted from raw horizontal and vertical force data, measured between hands-off and take-off instants, resulting in the propulsive forces. The application of the algorithm has evidenced that backstrokers’ horizontal and vertical simulated-structural-force components contributed to ~40% of total force during start propulsion (~0.2–0.12 s before the take-off), followed by the propulsive horizontal force increment and a progressive vertical component reduction (~0.05 s) with ~20° take-off angle. Based on these findings, researchers and coaches can better guide swimmers as to the proper mechanical strategies to achieve effectiveness in the backstroke start, and to improve direct transfer of resistance training programs.
Research on dual-arm coordination motion control strategy for power cable mobile robot

Regarding the typical operation tasks in high-voltage transmission line environment, in order to effectively eliminate or reduce the disadvantageous effects on the robot operation reliability caused by the close chain internal forces. According to the motion status of manipulator operation, the dual-arm coordination control of the mobile operation robot can be divided into three different modes, which are dual-arm independent operation mode, dual-arm fully constrained mode and dual-arm partially constrained mode. The dynamic model between dual-arm and operation objects for the three different models are established, respectively. The manipulator position and force are set as the control targets, a unified dual-arm coordination controller is designed for the three operation modes. Through the mutual compensation of force error and position error, the close chain internal force can be dynamically allocated in each joints, so that the robot joints force can be balanced during the operation, and the internal force in the close chain can be minimized during the operation process so as to ensure the operation reliability and safety. Finally, the validity and engineering practicability is verified by MATLAB simulation experiment and 220 kV living damper replacement and drainage plate bolt tightening operation experiment, respectively.
Simulation de Globules Rouges modèles, et analyse analytique de modèles de suspensions très concentrées.

L'objectif principal de cette these est consacre a l'etude de la dynamique et la rheologie d'une suspension de particules denses qui se comportent comme des fluides complexes. La premier partie de cette these est consacree a l'etude de la deformation, le comportement dynamique et la rheologie d'une suspension de vesicule (un modele simple pour les globules rouges) sous l'action d'un ecoulement externe applique (cisaillement simple et Poiseuille confine) dans la limite de faible nombre de Reynolds. L'etude basee sur des simulations numeriques en utilisant la methode des integrales de frontiere. Cette etude est inspiree par le comportement des globules rouges dans le systeme microvasculaire. Notre etude est ensuite consacree aux effets du confinement et du nombre capillaire sur la forme, le comportement dynamique et la viscosite effective d'une suspension de vesicules. Nous avons montre que pour des membranes rigides (nombre capillaire petit), on peut observer en plus de la forme parachute et pantoufle, les formes suivantes : (i) forme d'oscillation centree, (ii) forme d'oscillation decentree et (iii) la forme cacahuete. Egalement, nous avons examine l'influence du contraste de viscosite sur la dynamique et la rheologie d'une vesicule. Nous avons montre qu'il existe une phase de "coexistence" entre la forme pantoufle et la forme parachute. Dans la deuxieme partie de cette these, nous avons propose un modele analytique et une etude numerique pour etudier les proprietes dynamiques et rheologiques d'une suspension de particules rigides sous ecoulement de Poiseuille confine. Le debit, la dissipation et la viscosite apparente sont etudies en fonction de la structure des plaques dans le canal. Egalement, l'etude numerique d'une suspension de particules spheriques (formes des chaines de particules) est en accord qualitatif avec le modele analytique qui considere les longues plaques. Cette etude numerique est basee sur une methode de la dynamique des particules du fluide, ou les particules sont representees par un champ scalaire ayant une viscosite elevee a l'interieur.
The Effect of Emotional Intelligence and Mental Health Towards Employee Performance Mediated by Job Satisfaction

This study aims to determine the effect of emotional intelligence and mental health on employee performance mediated by job satisfaction at Bank Rakyat Indonesia X Regency employees. This study used a quantitative research method by distributing questionnaires to 100 employees of Bank Rakyat Indonesia in X Regency. The sampling technique used in this study is saturated or census sampling. The final sample in the study amounted to 75 respondents. The analytical tool used in this study uses SmartPLS version 3.0 analysis with the structural equation modelling or SEM analysis method. The results of this study explain that; (1) there is no positive and significant effect of emotional intelligence on job satisfaction, (2) there is a positive and significant effect of mental health on job satisfaction, (3) there is a positive and significant effect of job satisfaction on employee performance, (4) there is no effect of satisfaction work mediates emotional intelligence on employee performance, and (5) there is an effect of job satisfaction mediating mental health on employee performance.
Wage growth in Lithuania from 2008 to 2020: observed drivers and underlying shocks

ABSTRACT This paper studies the drivers of wage growth in Lithuania over the period 2008–2020. Using administrative data as well as aggregate measures reflecting the state of the economy, we estimate an extended version of a wage Phillips curve. Our reduced-form estimates indicate that nominal wage growth was tightly linked to labor market fluctuation over this period. Labor productivity, changes in the minimum wage, and the composition of employment also contributed to wage dynamics. However, we find little evidence that past inflation has been a push factor. To understand the underlying economic primitives behind our findings, we estimate a structural Bayesian autoregressive model. Our structural analysis reveals a significant contribution from aggregate supply shocks, reflecting a stronger relationship between productivity and wages than implied by our reduced-form estimates. Moreover, a historical decomposition reveals that since 2013, wages grew over and above productivity due to rising aggregate demand and labor market disturbances.
Quantification of short‐term transformations of proglacial landforms in a temperate, debris‐charged glacial landsystem, Kvíárjökull, Iceland

Proglacial areas are dynamic landscapes and important indicators of geomorphic changes related to climate warming. Systematic and repeat surveys of landforms presently evolving on glacier forelands facilitate the quantification of rates of change and an improved understanding of the processes generating those changes. We report short‐term (2014–2022) transformations of the proglacial landscape in front of Kvíárjökull, SE Iceland, and place them in a longer‐term context of glacial landsystem evolution using aerial image archives since 1945. Short‐term quantification uses a time series of uncrewed aerial vehicle (UAV) surveys, processed utilizing a structure‐from‐motion (SfM) workflow, to produce digital elevation models (DEMs) and orthophoto mosaics. The land elements surveyed include a kame terrace staircase, an outwash plain, an ice‐cored hummocky moraine complex and ice‐cored hummocky terrain with discontinuous sinuous ridges, for which elevation and volumetric changes are quantified. The kame terraces between 2014 and 2022 and the outwash plain between 2016 and 2022 were mainly stable with, respectively, 87% and 85% of their surfaces showing no change. The ice‐cored hummocky terrain with discontinuous sinuous ridges underwent a volume loss of 64,632 m3 in 2016–2022, with a maximum surface lowering of ≤9 m. The most dynamic land element was the ice‐cored hummocky moraine complex, with transformations recorded for more than 87% of its area in 2014–2022; the surface was lowered by ≤23 m in some places, with a total volume loss of 365,773 m3. Our results confirm the ongoing degradation of ice‐cored moraine and outwash complexes at variable rates related to buried ice volume and age of deglaciation. The evolution of chaotic hummocky terrain from debris‐covered glacier ice, glacitectonic thrust masses, outwash fans/heads and complex englacial esker networks is an important modern analogue for informing palaeoglaciological reconstructions.
Cyclodextrins for the Delivery of Bioactive Compounds from Natural Sources: Medicinal, Food and Cosmetics Applications

Cyclodextrins have gained significant and established attention as versatile carriers for the delivery of bioactive compounds derived from natural sources in various applications, including medicine, food and cosmetics. Their toroidal structure and hydrophobic cavity render them ideal candidates for encapsulating and solubilizing hydrophobic and poorly soluble compounds. Most medicinal, food and cosmetic ingredients share the challenges of hydrophobicity and degradation that can be effectively addressed by various cyclodextrin types. Though not new or novel—their first applications appeared in the market in the 1970s—their versatility has inspired numerous developments, either on the academic or industrial level. This review article provides an overview of the ever-growing applications of cyclodextrins in the delivery of bioactive compounds from natural sources and their potential application benefits.
Plastic ingestion in adult and fledgling Manx Shearwaters Puffinus puffinus on Skomer Island, Wales

Plastic debris is ubiquitous in the marine environment, and seabirds are among the most impacted marine vertebrates. Plastic ingestion was investigated in an internationally-important breeding population of Manx Shearwaters Puffinus puffinus on Skomer Island, Wales in 2018–19. Opportunistic necropsies were carried out on a total of 34 birds to collect contents of the gastrointestinal tract: 13 adults from April to July 2019 and 12 fledglings during September 2019, and a further nine opportunistic necropsies carried out from adults from July to September 2018. The presence, quantity, size and colour of plastic in the gastrointestinal tract was investigated. Plastic was found in 71% of Manx Shearwater stomachs (68% of adults, 75% of fledglings). Adults were found to have larger plastic pieces in their gastrointestinal tract than fledglings, and lighter birds had larger pieces of plastic in their tracts than heavier birds. This study shows that Manx Shearwaters on Skomer Island are vulnerable to plastic ingestion, and that adults are likely to pass plastic to their chicks.
Cost-Effectiveness of New Quadruple Therapy Compared With Standard Treatment for Patients With Heart Failure in China

Supplemental Digital Content is Available in the Text. Abstract: This study aimed to compare the cost-effectiveness of the new quadruple therapy regimen of adding sodium-glucose–linked transporter 2 (SGLT2) inhibitors, with standard treatment for patients with heart failure (HF) in China. From the payer's perspective, the dates of cardiovascular event recurrences were extracted from a meta-analysis including 6 trials, combined with the treatment cost for patients with HF in China to construct a Markov model. The outcomes included per capita medical costs and incremental cost-effectiveness ratio, using quality-adjusted life years (QALYs) data. Single-factor, probability sensitivity analysis, and scenario analysis were used to explore the potential uncertainties of the model. The per capita costs of the new quadruple therapy regimen and standard treatment were $87441.26 and $87087.54, respectively. The new regimen was associated with a mean of 21.44 QALYs gained, compared with 18.60 QALYs gained with the standard treatment. The incremental cost-effectiveness ratio was $124.03 per QALY gained. The sensitivity analysis revealed that changes in the parameters within the set range did not affect the model results. In China, compared with standard treatment, the new quadruple therapy regimen with SGLT2 inhibitors reduce the frequency of cardiovascular events among patients with HF, and it has economic advantages.