Miracle-dz/UniFAR-FTUs huggingface dataset:
Human papillomavirus (HPV) vaccination and oropharyngeal HPV in ethnically diverse, sexually active adolescents: community-based cross-sectional study

Objectives Oropharyngeal squamous cell carcinoma is the most common human papillomavirus (HPV)-associated cancer in the UK, but little is known about the prevalence of oropharyngeal HPV in sexually active teenagers. We investigated reported HPV vaccination coverage (in females) and prevalence of oropharyngeal HPV in sexually active students attending six technical colleges in London, UK. Methods In 2017, we obtained mouthwash samples and questionnaires from male and female students taking part in the ‘Test n Treat’ chlamydia screening trial. Samples were subjected to HPV genotyping. Results Of 232 participants approached, 202 (87%) provided a mouthwash sample and questionnaire. Participants’ median age was 17 years and 47% were male. Most (73%) were from black and minority ethnic groups, 64% gave a history of oral sex, 52% reported having a new sexual partner in the past 6 months, 33% smoked cigarettes, 5.9% had concurrent genitourinary Chlamydia trachomatis infection and 1.5% Neisseria gonorrhoeae and 5.0% were gay or bisexual. Only 47% (50/107) of females reported being vaccinated against HPV 16/18, of whom 74% had received ≥2 injections. HPV genotyping showed three mouthwash samples (1.5%, 95% CI 0.3% to 4.3%) were positive for possible high-risk human papillomavirus (HR-HPV), one (0.5%, 0.0% to 2.7%) for low-risk HPV 6/11, but none (0.0%, 0.0% to 1.8%) for HR-HPV. Four samples (2.0%, 0.5% to 5.0%) were positive for HPV16 using a HPV16 type-specific quantitative PCR, but these were at a very low copy number and considered essentially negative. Conclusions Despite the high prevalence of oral sex and genitourinary chlamydia and low prevalence of HPV vaccination, the prevalence of oropharyngeal HR-HPV in these adolescents was negligible.
The role of employee engagement as a mediating effect in influencing corporate culture and human capital of defense industry

These days, public and private organization have faced a new challenge to reach its value added products caused by the rise of globalization. It is characterized by the uncertain and turbulence environment. Consequently, every organization has to embrace a continuous improvement in order to reach an organization effectiveness. Similarly, defense industries are trying to produce advance defense weapon system. In Asia country, such as, China, Japan, South Korea, Taiwan and Singapore defense industry capability have developed significantly. Defense Industry is a complex organization with high technology platform. In the future, Indonesia defense industries need to improve its effectiveness by benchmarking with other advance defense industries nation. Currently, defense industries in the world have changed the way they are doing business in order to adapt and respond the new environment. Diversification strategy, restructuring, downsizing, merger and acquisition strategy have done to streamline the organization. However, these strategies are not enough, while culture and employee have not grasped carefully. Therefore, the crucial prerequisite to develop an effective defense industry is transforming corporate culture, developing human capital and improving employee engagement.
Stacked Support Vector Machine Ensembles for Cross-Culture Emotions Classification

Facial expressions play a main role in representing the human’s internal emotional state in social communication, but the scope to which they are universal and culture reliant is a subject of discussion. In this paper, we introduced the Stacked Support Vector Machine Ensembles (SVMEs) for cross-culture emotions classification. A pool of SVM ensembles is stacked to learn the cross-culture emotions. The SVM ensemble is a collection of a set of support vector machines. The outcomes of support vector machines were tied to the probability distribution across the support vector machine ensembles. The final decision about the presence of an emotion is made by naive Bayes predictor. The cross-cultural facial images from JAFFE, TFEID, KDEF, CK+ and RadBoud databases are combined to develop the multi-culture dataset. The participants of multi-culture database originate from following geography and ethnicity: Japanese, Taiwanese, Caucasians, Moroccans, Swedish, Asians, Northern Europeans, Euro-American, and Afro-American. The experimental results and inter-expression resemblance analysis demonstrate that the proposed ensemble approach performs significantly better than the stat-of-the-art ensemble techniques.
Systematic Covariations and Emerging Asian Equity Markets’ Diversification Benefits to US Equity Investors

Unconditional and conditional correlations have played a central role in portfolio analysis, optimization, and performance measurement. However, recent studies show these two correlation measures are inappropriate for measuring both financial integration and, therefore, diversification benefits. We use an alternative correlation measure that we refer to by factor model-implied correlation estimated from the systematic (predictable) portion of returns of a multi-factor model with several global risk factors. Estimated implied correlations, covariances, variances, and in-sample (predicted) mean returns are used to calculate optimal US and Asian equities’ asset allocation weights in alternative Global equity portfolios varying by Asian equity market combined with US equities, as well as by whether: (i) implied or unconditional statistics are used; and (ii) portfolios are optimized by Sharpe’s ratio-maximization or variance-minimization. Risk-adjusted returns of alternative actively-managed Global equity portfolios are compared to US equities’ risk-adjusted returns. We find Global equity portfolios with asset allocation weights calculated using factor model-implied statistics uniformly yield higher risk-adjusted returns than US equities and Global equity portfolios with asset allocation weights calculated using unconditional portfolio statistics. In actively-managed Global equity portfolios with asset allocation weights calculated using implied statistics, India and Taiwan consistently rank as top contributors, while South Korea, Singapore, and Hong Kong consistently rank as bottom contributors to enhancing US equities’ risk-adjusted returns. While our analyses are dynamic, they use implied portfolio statistics estimated from historical returns’ distributions. Future studies can extend this research using conditional(out-of-sample) ex-ante estimates of systematic returns, covariances, variances, and correlations in examining emerging markets’ contributions to developed markets’ equities.
MicroRNA-146a Expression and Serum Interleukin-17 Level as potential biomarkers for Rheumatoid Arthritis

Small non-coding RNAs are microRNAs (miRNAs) that can play a role in controlling various immune functions. MicroRNA146a (miRNA-146a) is regarded as an essential element in posttranscriptional gene expression regulator, indicating a possible function in autoimmune diseases. Aim: The aim of the research was to evaluate the expression of miR-146a and Interleukin17 serum levels as potential markers for rheumatoid arthritis (RA) diagnosis and to investigate its association with the activity of the disease. Methods: This research comprised 60 subjects divided into 30 RA patients and 30 healthy individuals. The rate of erythrocyte sedimentation rate (ESR), anti-cyclic-citrullinated peptide (anti-CCP) antibodies rheumatoid factor (RF), Creactive protein (CRP) and serum IL-17 level were estimated. Using reverse transcriptase real time polymerase chain reaction quantitative, the relative quantification of miR-146a expression was determined. Results: There are highly pronounced statistical variations was observed between patients and healthy controls, with relative expression of miR-146a, (ESR), CRP, IL-17 and (anti-CC). There are also extremely important statistical differences (p < 0.001) between the various patient subgroups with respect to miR-146a relative expression. IL-17 level in the RA group was higher than in the control group. Positive associations were noticed between the levels of IL-17, ESR, CRP, (anti-CCP) and miR-146a. Conclusion: This study showed that even the expression of miR-146a was highly significant in RA patients, the level of expression was associated with the activity of the disease. Also, the increase in serum IL-17 in patients with RA compared with healthy controls played an important role in the diagnosis of the inflammatory and destructive characteristics of RA.
As Mainstream and Alternative Media Converge?: Critical Perspectives from Asia on Online Media Development

ABSTRACT As boundaries blur between mainstream and alternative media online, with each taking on characteristics of the other, much research has centered on their convergence within the liberal West, and their continued divergence in authoritarian states like in the Middle East. This study uniquely examines this alternative-mainstream dichotomy in hybrid societies susceptible to Western liberal ideals but whose media systems are subjected to authoritarian control or influence, by examining Asia’s two global cities, Singapore and Hong Kong. Through in-depth interviews with online newsworkers, this study uncovers how they define “alternativeness” in the digital age and their assessments on how “alternative” their news outlets currently are or are able to become. By analyzing their content offerings, community and audience engagements, organizational structures, and ownership and control, results indicate that the online space has not caused a significant merge between alternative and mainstream media in these two cities. That said, the extent to which Hong Kong’s online-only news outlets are “alternative” is much more significant than in Singapore, particularly where political engagement is concerned. Additionally, what it means to “be alternative” is also vastly different, pointing to the need to acknowledge both differences in “how alternative” and “what alternative is” across contexts.
Pembrolizumab in Asian patients with microsatellite‐instability‐high/mismatch‐repair‐deficient colorectal cancer

The phase 3 KEYNOTE‐177 study evaluated pembrolizumab versus chemotherapy with or without bevacizumab or cetuximab in patients with newly diagnosed, microsatellite‐instability‐high (MSI‐H)/mismatch‐repair‐deficient (dMMR) metastatic colorectal cancer (mCRC). Primary endpoints were progression‐free survival (PFS) per RECIST v1.1 by blinded independent central review (BICR) and overall survival (OS). Secondary endpoints were overall response rate (ORR) per RECIST v1.1 by BICR and safety. Here, we report results from the post hoc analysis of patients who were enrolled in Asia from the final analysis (FA) of KEYNOTE‐177. A total of 48 patients from Japan, Korea, Singapore, and Taiwan (pembrolizumab, n = 22; chemotherapy, n = 26) were included. At FA, median time from randomization to data cutoff (February 19, 2021) was 45.3 (range 38.1–57.8) months with pembrolizumab and 43.9 (range 36.6–55.1) months with chemotherapy. Median PFS was not reached (NR; 95% confidence interval [CI] 1.9 months–NR) with pembrolizumab versus 10.4 (95% CI 6.3–22.0) months with chemotherapy (hazard ratio [HR] 0.56, 95% CI 0.26–1.20). Median OS was NR (range 13.8 months–NR) versus 30.0 (14.7–NR) months (HR 0.65, 95% CI 0.27–1.55) and ORR was 50% (95% CI 28–72) versus 46% (95% CI 27–67). Grade 3/4 treatment‐related adverse events (TRAEs) were reported by two patients (9%) in the pembrolizumab arm and 20 (80%) in the chemotherapy arm. Immune‐mediated adverse events or infusion reactions were reported by six patients (27%) and 10 patients (40%), respectively. No deaths due to TRAEs occurred. These data support first‐line pembrolizumab as a standard of care for patients from Asia with MSI‐H/dMMR mCRC. ClinicalTrials.gov identifier: NCT02563002.
The Possibility of Healthy Organizations: Toward a New Framework for Organizational Theory and Practice

The fields of organizational sociology and organizational development contain considerable literature dealing with organizational effectiveness, but little that focuses explicitly on organizational health. This paper clarifies the notion of “healthy organizations” and describes how it needs to be fed by practice, so that social scientists do not build theories that are unrelated to the reality that people experience in organizations today. This delineation of “organizational health” as an arena of inquiry is built on the definition of health developed by the World Health Organization, and on the writing of behavioral scientists (Argyris, Bruhn, Cooley, Etzioni, Kilburg, Levinson, Sorokin, and Whyte) and non-traditional thinkers and practitioners (G.I. Gurdjieff, Oscar Ichazo, Charles G. Krone, Moshe Feldenkrais, and Tenzin Gyatso, the 14th Dalai Lama). Sociological practice can contribute significantly to the creation of “organizations of the future” (Argyris, 1973) in which a state of reciprocal maintenance (Bennett, 1976) exists between individuals and organizations. “Reciprocal maintenance” means that neither partner seeks to take advantage of the other: the organizations are designed to enable the growth and development of their members or workers (in the broadest sense, including managers) and the individuals do their best to enhance the organization's long-term viability. I define as “healthy” those organizations that foster such reciprocal maintenance while creating an organizational culture in which people have more influence and control over the decisions that affect their lives.
Electrical Power System Dynamic Stability Evaluation using a Knowledge-Based Approach

In this paper, dynamic stability assessment of electrical power systems is formulated as a pattern recognition problem so that it is fast and accurate enough for on-line applications. The problem concerned is the potentially hazardous dynamic instability of the interconnected power system between Hong Kong and China. New techniques, such as the Branch and Bound Search, are employed to achieve optimality in Feature Selection. In Feature Extraction where further dimensionality reduction is made, matrix augmentation is used to extract information content in class-centralised vectors as well as in class-mean vectors. Finally, for improvement of classification efficiency, an innovative approach making use of partitioning and decision tree search is pursued to tackle the non- linearly separable patterns which exist uniquely in the study of dynamic stability.
How Past Failure Predicts Subsequent Entrepreneurial Intention: A Comparative Study of Mainland China and Taiwan

Entrepreneurship is the center of economic growth process, and it is context-sensitive. We compare Mainland China and Taiwan by investigating the impact of past failure on individual entrepreneurs. Using a large amount of data from GEM (Global Entrepreneurship Monitor), a logistic regression approach was adopted and most of the major variables in models are correlated positively. We demonstrate that past failure does affect entrepreneurs’ perceived capability and next enterprising activity positively in the two regions. Unlike the moderating role of culture, entrepreneurial motivation exerts a quite different impact on the relationship between past failure and entrepreneurs’ future intention in the two regions. Our results provide not only theoretical implications for context-related entrepreneurial motivation, but practical suggestions for entrepreneurs and policy makers.
Digital Smartphone Tracking for COVID-19: Public Health and Civil Liberties in Tension.

Contact investigations have been a vital public health strategy, most recently in controlling tuberculosis and sexually transmitted infections including HIV. Yet, the sheer scale of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections poses major challenges to contact investigations. Strategies in China, Singapore, South Korea, and Taiwan have supplemented traditional manual approaches with digital surveillance through smartphone applications. The US has not used digital surveillance as a tool, but Google, Apple, the Massachusetts Institute of Technology (MIT), as well as 2 pan-European consortia and a variety of independent efforts are developing Bluetooth smartphone technology to enable rapid notification of users that they have had a close exposure to individuals diagnosed with medically verified coronavirus disease 2019 (COVID-19). How does digital tracking differ from manual tracing? Although digital surveillance has the distinct advantages of scale and speed, does it confer sufficient public health benefit to justify adoption given privacy concerns? How do the design choices of digital contact tracing systems affect public health and privacy?
An Estimation of the Total Number of Cases of NCIP (2019-nCoV) — Wuhan, Hubei Province, 2019–2020

On December 31, 2019, the World Health Organization (WHO) was alerted to several cases of pneumonia of unknown etiology in Wuhan, the capital city of Hubei Province in Central China. A novel coronavirus (2019-nCoV) was identified as the causative virus by Chinese authorities on January 7, 2020 (1), and China CDC has named the associated disease as novel coronavirus-infected pneumonia (NCIP) (2–3). As of January 23, 2020, the National Health Commission (NHC) of China had confirmed a total of 830 cases of NCIP in Mainland China, including 177 in critical condition, 25 fatalities, and 34 recoveries. In Wuhan the origin of the NCIP outbreak, 495 cases including 24 fatalities have been confirmed. In addition to the cases in Mainland China, two cases have been detected in Hong Kong Special Administrative Region, China, two in Macao Special Administrative Region, China, one in Taiwan, China, and a total of nine cases have been detected outside China in Thailand (4 cases), Vietnam (2 cases), USA (1 case), Japan (1 case), Republic of Korea (1 case) and Singapore (1 case) (4). The current epidemiological information has indicated that most of the global cases were directly imported from Wuhan. Therefore, a careful and precise understanding of the total number of cases in Wuhan is crucial for decision making and prevention of NCIP. There has already been a considerable investment of resources in Wuhan in order to combat the spread of NCIP. However, estimating the magnitude of the epidemic in Wuhan based on the reported number of confirmed cases is difficult due to the virus’ lengthy incubation period and variable symptom presentation (sometimes without the presence of fever or other symptoms), overburdened medical resources and personnel, and time added to receive test results from China’s NHC and China CDC. In this article, a method for estimating the total number of NCIP-onset cases within Wuhan is proposed using the number of cases detected outside Hubei Province.
Proteomic Analysis of Thermal Regulation of Small Yellow Follicles in Broiler-Type Taiwan Country Chickens

Heat stress hampers egg production and lowers fertility in layers. This study investigated global protein abundance in the small yellow follicles (SYFs, 6–8 mm diameter) of a broiler-type strain of Taiwan country chickens (TCCs) under acute heat stress. Twelve 30-week-old TCC hens were allocated to a control group maintained at 25°C, and to three acute heat-stressed groups subjected to 38°C for 2 h without recovery, with 2-h recovery, or with 6-h recovery. Two-dimensional difference gel electrophoresis analysis identified 119 significantly differentially expressed proteins after acute heat exposure. Gene ontology analysis revealed that most of these proteins are involved in molecular binding (34%), catalytic activity (23%), and structural molecule activity (11%), and participate in metabolic processes (20%), cellular processes (20%), and cellular component organization or biogenesis (11%). Proteins associated with stress response and survival (HSP25, HSP47, HSP70, HSC70, HSPA9), cytoskeleton remodeling, mitochondrial metabolic process of ATP production, antioxidative defense (peroxiredoxin-6), cargo lipid export and delivery (vitellogenin, apolipoprotein B and A1), and toxin/metabolite clearance and delivery (albumin) were upregulated after acute heat stress in the SYFs of TCCs. No overt cell death and atresia were observed in SYFs after acute heat stress. Collectively, these responses may represent a protective mechanism to maintain follicle cell integrity and survival, thereby ensuring a sufficient pool of SYFs for selection into the ovulation hierarchy for successful egg production.
DNA-based diversity assessment reveals a new coral barnacle, Cantellius alveoporae sp. nov. (Balanomorpha: Pyrgomatidae) exclusively associated with the high latitude coral Alveopora japonica in the waters of southern Korea

In the present study, the Indo-Pacific coral associated barnacle Cantellius euspinulosum (Broch, 1931) was found to have cryptic species in Korea, Taiwan and other regions based on molecular studies. However, the original specimens of C. euspinulosum from Broch have not been previously described or illustrated, making it difficult to assign which cryptic species to the original C. euspinulosum. The original specimen of C. euspinulosum was examined and illustrated here, and the species identity of C. cf. euspinulosum collected from Jejudo Island in the present study and other cryptic species (based on literature illustrations) in the Indo-Pacific were evaluated.C. euspinulosum from Singapore, Java, Mergui Archipelago in Andaman Sea and Nha Trang represented the C. euspinulosum identified by Broch (1931). It is a generalist on Acropora, Favia, Favites, Leptoria, Montipora, Pachyseris and Pocillipora corals and distributed in the Indo-Pacific region. Morphological examination and DNA sequencing (COI, 12S DNA sequences) in the present study showed that C. cf. euspinulosum from Jejudo Island, Korea represents a distinct species, herein named C. alveoporae sp. nov. Cantellius alveroporae sp. nov. is a specialist species that only grows on Alveopora and also present in Palau, and Ogasawara Island in Japan. Cantellius cf. euspinuloum in Taiwan, the Moscos Island, and Australia belong to several other distinct species awaiting further morphological and molecular studies. At least five cryptic species of C. euspinulosum were identified in the present study, including both specialist and generalists.
Chemical composition of mycelia of different collections of coprinoid mushrooms

ous taxonomists. The genus Fibrodontia was excluded from consideration; the genus Botryodontia was added to our concept. Thus all 13 hyphodontioid genera belong to the order Hymenochaetales. In the whole, Hyphodontia s. l. incorporates 127 accepted species. More than 40% of them were described in last 25 years and 22 species were described in last decade. Type localities for species of Hyphodontia s. l. are concentrated in three main countries: Taiwan (20 species), Sweden (15 species), and Argentina (14 species). At least 16 provisional new species, each as a single specimen, were distinguished by us among collections from China, Taiwan and Vietnam, stored in TNM herbarium.