Miracle-dz/UniFAR-FTUs huggingface dataset:
Standardization of TP 53 gene mutations analysis on oral squamous cell carcinoma from paraffin-embedded tissues

First submission on 16/08/13; last submission on 28/01/14; accepted for publication on 18/02/14; published on 20/04/14 1. Doctorate in Pathology from Universidade Federal Fluminense (UFF). 2. Doctorate in Pathology from UFF; associate professor at the Dentistry School of UFF in Nova Friburgo. 3. Doctorate in Materials/Biomaterials Science from Universidade Federal do Rio de Janeiro (UFRJ); associate professor at the Department of Education in Health of Universidade Federal do Sergipe (UFS). 4. Master’s degree in Public Health from Fundação Oswaldo Cruz (Fiocruz); physician at the Pathology Division (Dipat) of Instituto Nacional de Câncer (Inca). 5. Doctorate in Medicine from Universidade de São Paulo (USP); full professor of Head and Neck Surgery at the Post-Graduate School of Medicine, Pontifícia Universidade Católica do Rio de Janeiro (PUC-RJ). 6. Doctorate in Pharmacy from USP; senior associate professor at the Pathology Department of UFF. 7. Doctorate in Biological Sciences from Universidade do Estado do Rio de Janeiro (UERJ); senior associate professor at the Department of Cellular and Molecular Biology of UFF. 8. Doctorate in Pathology from Faculdade de Odontologia de Bauru (FOB/USP); senior associate professor at the Pathology Department of UFF. ABStrACt
Role of Fatty Acids in the Resolution of Autoimmune and Inflammatory Diseases

The main role of fatty acids is focused on serving as major substrates for energy production; however, fatty acids are also involved in the formation of cellular structures as well as in the transmission of cellular signals. Among the multiple functions attributed to fatty acids are their anti-inflammatory properties. This important characteristic has been applied in the prevention, attenuation or treatment of inflammatory disorders. Based on the previous argument is obvious that several fatty acids (mainly n-3 polyunsaturated or n-9 monounsaturated fatty acids) are capable of modulating immune system functions. These fatty acids may alter immune response through different mechanisms such as alteration of membrane fluidity, eicosanoid synthesis, oxidative stress, regulation of gene expression, apoptosis or modulation of gastrointestinal microbiota. Early studies in Greenland Eskimos determined the low prevalence of inflammatory disorders in this population (Kromann et al., 1980). Despite their beneficial effects in the reduction of inflammatory diseases, other studies have demonstrated that the administration of diets containing long-chain n-3 polyunsaturated fatty acids may contribute, at least in part, to the reduction of host resistance against infectious agents. In fact, epidemiological investigations described a high incidence of tuberculosis in native Eskimos (Kaplan et al., 1972), who consume a great amount of n-3 polyunsaturated fatty acids. These data are clearly illustrative of the potential action of certain fatty acids on the inflammatory response, and of the consequences derived from an excessive immunosuppression. It is obvious that these fatty acids contained in the diets produce an immune status able to ameliorate inflammatory conditions. Indeed, a growing number of studies using healthy human subjects as well as animal disease models have undoubtedly demonstrated dietary fish oil or olive oil to possess anti-inflammatory properties. For this reason, polyunsaturated or monounsaturated fatty acids have showed beneficial effects in numerous inflammatory diseases characterized by a overactivation of immune system such as asthma (childhood and adult), multiple sclerosis, glomerulonephritis, inflammatory bowel disease (Crohn’s disease, ulcerative colitis) and rheumatoid arthritis . Here, we summarize the involvement of fatty acids as anti-inflammatory agents and the action that these fatty acids contained in the human or animal diets exert on the prevention or treatment of autoimmune diseases.
Multi-scale characterization of biomaterials using complementary X-ray and electron imaging techniques

iv ACKNOWLEDGEMENTS . v LIST OF FIGURES . viii LIST OF TABLES . xi LIST OF ABREVIATIONS . xii DECLARATION OF ACHIEVEMENT. xiii CHAPTER 1: INTRODUCTION . 1 Development of Biomaterials . 1 Motivation and Aims . 2 Complementary Imaging Techniques . 3 X-ray Micro-Computed Tomography . 3 X-ray Interactions with Matter and Attenuation . 4 Biomaterial Imaging Using Micro-Computed Tomography . 5 Electron Microscopy . 7 Electron Interactions with Matter . 8 Biomaterial Imaging Using Electron Microscopy . 11 CHAPTER 2: OSSEOINTEGRATION OF A TITANIUM DENTAL IMPLANT . 13 Motivation and Aims . 13 Background . 14 Bone Structure . 14 Macroscale . 14 Microscale . 15 Nanoscale . 15 Histology . 16 Methods and Materials . 17 Implants . 17 SIT Implant Characterization . 17 Implant Placement and Retrieval . 18 Histology . 19 Micro-Computed Tomography . 19
Is There a Method to the BPM Madness? A Review of Two Books Describing a New Foundation for Business Process Management

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Customer journey identification through temporal patterns and Markov clustering

Companies want insights in the behavior of their customers across multiple contact channels. Current techniques for identifying customer journeys are based on interviews and manually creating the model. Due to this limitation, not all journeys can be analyzed. Customer Relationship Management Systems store all kinds of logs when a customer contacts a company. As this data is too large to analyze by hand, a technique based on data is needed. Process discovery algorithms obtain process models from event logs. Customers can have multiple journeys in parallel. As a result, applying process discovery algorithms directly on such a set, incorrect insights are obtained. Hence, a tool is needed that is able to discover customer journeys from a dataset. However, such a technique does not exist yet. In this thesis, a new technique is proposed for identifying customer journeys from a large dataset. The input for such a technique is an event log in which each customer is represented as a single trace, i.e. each trace contains all events of a single customer. In this thesis, an event is a moment on which the customer contacted the company. With the output of the technique, an analyst should be able to obtain and analyze customer journeys. To show the practical application of the developed technique, it is implemented as a plug-in for ProM. Using this ProM plug-in, a case study has been conducted using data from CZ, a health insurance company in the Netherlands. With this case study, it is shown that the technique is able to distinguish the different customer journeys for each customer.
On sets with more products than quotients

Given a finite set $A\subset \mathbb{R}\backslash \{0\}$, define \begin{align*}&A\cdot A \ =\ \{a_i\cdot a_j\,|\, a_i,a_j\in A\},\\ &A/A \ =\ \{a_i/a_j\,|\,a_i,a_j\in A\},\\ &A + A \ =\ \{a_i + a_j\,|\, a_i,a_j\in A\},\\ &A - A \ =\ \{a_i - a_j\,|\,a_i,a_j\in A\}. \end{align*} The set $A$ is said to be MPTQ (more product than quotient) if $|A\cdot A|>|A/A|$ and MSTD (more sum than difference) if $|A + A|>|A - A|$. Since multiplication and addition are commutative while division and subtraction are not, it is natural to think that MPTQ and MSTD sets are very rare. However, they do exist. This paper first shows an efficient search for MPTQ subsets of $\{1,2,\ldots,n\}$ and proves that as $n\rightarrow \infty$, the proportion of MPTQ subsets approaches $0$. Next, we prove that MPTQ sets of positive numbers must have at least $8$ elements, while MPTQ sets of both negative and positive numbers must have at least $5$ elements. Finally, we investigate several sequences that do not have MPTQ subsets.
Selective depth-first game-tree search

This thesis continues an ongoing study of algorithms for selective depth-first expansion of game trees (for two-person zero-sum perfect-information board games). The question we are primarily concerned with is: how should game-playing programs spend their search effort to maximize the quality of their move decisions? This is a challenging problem. Early attempts at selective expansion of game trees were not particularly successful, and were replaced by brute-force full-width searches once technological advances in both hardware and software made such approaches feasible. However, such brute-force methods are not sufficient on their own to produce world-class game-playing programs. Therefore, many new algorithms have been proposed for exploring game trees more selectively. On the one hand, there are algorithms that traverse the game trees in a best-first fashion but, unfortunately, these algorithms are neither time nor space efficient and have thus not found a wide use in practice. On the other hand, selective depth-first based search algorithms show more promise. This work introduces several algorithmic enhancements to state-of-the-art depth-first game-tree search. First of all, we show how speculative pruning can, if applied in a controlled manner, improve the search efficiency of existing game-tree search algorithms—without compromising the returned minimax value. Secondly, a novel domain-independent method for speculative pruning of game trees is presented, and its promise demonstrated in two different search domains. The method has been adapted by some of the world's leading chess-playing programs with good success. Finally, we introduce a method for automatically learning search-control parameters in two-person games, either from online play or by offline analyzes of game positions.
Securetrade: a secure protocol based on transferable E-cash for exchanging cards in P2P trading card games.

Trading card games (TCG) are distinct from traditional card games mainly because, in the former, the cards are not shared among players in a match. Instead, users play with the cards they own (e.g., that have been purchased or traded with other players), which correspond to a subset of all cards produced by the game provider. Even though most computer-based TCGs rely on a trusted third-party (TTP) for preventing cheating during trades, allowing them to securely do so in the absence of such entity, as in a Peer-to-Peer (P2P) scenario, remains a challenging task. Potential solutions for this challenge can be based on e-cash protocols, but not without adaptations, as those scenarios display different requirements: for example, TCGs should allow users to play with the cards under their possession, not only to be able to pass those cards over as with digital coins. In this work, we present and discuss the security requirements for allowing cards to be traded in TCGs and how they relate to e-cash. We then propose a concrete and efficient TTP-free protocol for trading cards in a privacy-preserving manner. The construction is based on a secure transferable e-cash protocol and on a P-signature scheme converted to the asymmetric pairing setting. According to our experimental results, the proposed protocol is quite efficient for use in practice: an entire deck is stored in less than 5 MB, while it takes a few seconds to be prepared for a match; the verification of the cards, on its turn, takes less time than an usual match, and can be performed in background while the game is played.
TOXICITY OF ACACIA NILOTICA FRIUTS WATER EXTRACT AGANIST BIOMOPHLARIA SNAILS.

Asharaf E. H 1 , Madani M 2 , Mohamed A.Y 3 and Nidal A 4 . 1. Military hospital central lab. 2. Department of Parasitology, Faculty of Medical Laboratory Sciences, Alneelain University, Khartoum, Sudan. 3. Medicinal and Aromatic plants Research institute, National Center for Research, 4. University of Khartoum, faculty of sciences, Department of zoology. Manuscript Info Abstract . Manuscript History
Derived equivalences and Gorenstein algebras Hiroki Abe and Mitsuo Hoshino

We introduce a notion of Gorenstein R-algebras over a commutative Gorenstein ring R. Then we provide a necessary and sufficient condition for a tilting complex over a Gorenstein R-algebra A to have a Gorenstein R-algebra B as the endomorphism algebra and a construction of such a tilting complex. Furthermore, we provide an example of a tilting complex over a Gorenstein R-algebra A whose endomorphism algebra is not a Gorenstein R-algebra. In this note, extending the notion of selfinjective artin algebras to noether algebras, we introduce a notion of Gorenstein algebras. Our main aim is to provide a necessary and sufficient condition for a tilting complex over a Gorenstein algebra to have a Gorenstein algebra as the endomorphism algebra. Let R be a commutative noetherian ring and A a noether R-algebra, i.e., A is a ring endowed with a ring homomorphism R → A whose image is contained in the center of A and A is finitely generated as an R-module. To define the Gorensteinness for A, we assume the base ring R is a Gorenstein ring (see [? ]). Then we call A a Gorenstein R-algebra provided that A has Gorenstein dimension zero as an R-module (see [? ]) and that DA is a projective generator in the category of right A-modules, where D = HomR(−, R). Assume A is a Gorenstein R-algebra. We will see in Section 3 that A satisfies the Auslander condition (see [? ]) and has selfinjective dimension at most dim R on both sides, where dim R denotes the Krull dimension of R. In particular, in case A is commutative, A is a Gorenstein ring. Also, in case dim R = 0, A is a selfinjective artin algebra. Furthermore, for any prime ideal p of R with Ap 6= 0 we will see that Ap is maximal Cohen-Macaulay as an Rp-module and has selfinjective dimension equal to dim Rp on both sides. It follows that A is a Gorenstein algebra in the sense of [? ] in which the theory of Gorenstein algebras is studied in detail. So we refer to [? ] for the relationship of the notion of Gorenstein algebras to the theory of commutative Gorenstein rings. Next, let P • be a tilting complex (see [? ]) over A and denote by B the endomorphism algebra of P • 2000 Mathematics Subject Classification. Primary 18E30, 16G30; Secondary 16E05
SNPMeta: SNP annotation and SNP metadata collection without a reference genome

The increase in availability of resequencing data is greatly accelerating SNP discovery and has facilitated the development of SNP genotyping assays. This, in turn, is increasing interest in annotation of individual SNPs. Currently, these data are only available through curation, or comparison to a reference genome. Many species lack a reference genome, but are still important genetic models or are significant species in agricultural production or natural ecosystems. For these species, it is possible to annotate SNPs through comparison with cDNA, or data from well‐annotated genes in public repositories. We present SNPMeta, a tool which gathers information about SNPs by comparison with sequences present in GenBank databases. SNPMeta is able to annotate SNPs from contextual sequence in SNP assay designs, and SNPs discovered through genotyping by sequencing (GBS) approaches. However, SNPs discovered through GBS occur throughout the genome, rather than only in gene space, and therefore do not annotate at high rates. SNPMeta can therefore be used to annotate SNPs in nonmodel species or species that lack a reference genome. Annotations generated by SNPMeta are highly concordant with annotations that would be obtained from a reference genome.
An ethnomedicinal survey of cucurbitaceae family plants used in the folk medicinal practices of Bangladesh 1

Background: The Cucurbitaceae family comprising about 125 genera and 960 species is a family that is further characterized by commonly having five-angled stems and coiled tendrils and is also known as gourd family of flowering plants. Plant species belonging to this family have a worldwide distribution, but most species can be found in tropical and subtropical countries. A number of the plants belonging to this family have reported important pharmacological activities. Cucurbitaceae family plants are also in use in the folk medicinal system of Bangladesh-a traditional medicinal system, which mainly relies on medicinal plants for treatment of diverse ailments. Aims: Since folk medicinal practitioners form the first tier of primary health care in Bangladesh, the objective of this study was to conduct ethnomedicinal surveys among 75 folk medicinal practitioners (Kavirajes) practicing among the mainstream Bengali-speaking population of randomly selected 75 villages in 64 districts of Bangladesh and 8 tribal practitioners (1 each from 8 major indigenous communities or tribes, namely, Bede, Chakma, Garo, Khasia, Marma, Murong, Santal, and Tripura) of the country. Materials and Methods: Surveys were carried out with the help of a semi-structured questionnaire and the guided field-walk method. Results: It was observed that the folk and tribal medicinal practitioners use a total of 19 Cucurbitaceae family species for treatment of ailments such as dysentery, diabetes, edema, skin disorders, leukoderma, hypertension, jaundice, typhoid, spleen disorders, respiratory problems, leprosy, rheumatoid arthritis, chicken pox, and cancer. The 19 species of Cucurbitaceae family plants in use were Benincasa hispida, Bryonopsis laciniosa, Citrullus colocynthis, Citrullus lanatu, Coccinia grandis, Cucumis melo, Cucumis sativus, Cucurbita maxima, Cucurbita pepo, Hodgsonia macrocarpa, Lagenaria vulgaris, Luffa acutangula, Luffa cylindrica, Momordica charantia, Momordica cochinchinensis, Trichosanthes anguina, Trichosanthes cordata, Trichosanthes dioica, and Trichosanthes kirilowii. The review of the available scientific literature showed that the use of a number of the above-mentioned plants in folk medicine can be validated based on their reported pharmacological activity studies. Conclusion: Taken together, the plants present excellent potential for further scientific studies, which may result in discovery of novel compounds of therapeutic interest.
ADAPTIVE DC LINK VOLTAGE FOR CPI VOLTAGE VARIATIONS FOR A THREE PHASE GRID TIED SPV SYSTEM

This proposed model manages a threestage two-organize grid tied SPV (sunlight based photograph voltaic) framework. The main stage is a help converter, which fills the need of MPPT (most extreme power point following) and sustaining the removed sunlight based vitality to the DC connection of the PV inverter, while the second stage is a two-level VSC (voltage source converter) serving as PV inverter which bolsters control from a support converter into the matrix. The point of this controller is to accomplish an ideal MPP operation without the need of barometrical conditions estimations and to improve the productivity of the PV control framework. This model likewise utilizes a versatile DC connect voltage which is made versatile by modifying reference DC interface voltage as per CPI (regular purpose of interconnection) voltage. The versatile DC connect voltage control helps in the decrease of exchanging force misfortunes. A sustain forward term for sun oriented commitment is utilized to enhance the dynamic reaction. A photovoltaic (PV) framework can create wide scopes of voltage and current at terminal yield. Be that as it may, a PV cell is required to practically keep up a consistent direct present (DC) voltage at a craved level amid constant varieties . To get this objective, a DC/DC converter together with control plot topology is utilized. A versatile PI control plan is proposed to settle the yield voltage of the DC/DC converter, with a specific end goal to keep up and balance out the Adaptive DC-connect voltage in like manner to the progressions of voltage at the Common Point of Interconnection before the framework. The Point of Common Coupling is a point in the electrical framework where various clients or numerous electrical burdens might be associated. This ought to be a guide which is open toward both the utility and the client for direct estimation. Extensive quantities of little scale sunlight based photovoltaic (PV) frameworks are being associated with the appropriation level of the power lattice PV frameworks are incorporated to the power network by means of force electronic converters. The model is tried considering reasonable matrix voltage varieties for under voltage varieties. This model is profitable not just in instances of incessant and managed under voltage (as in the instances of far outspread closures of Indian framework) additionally in the event of ordinary voltages at CPI. The THD (add up to music bending) of lattice current has been discovered well under the farthest point of an IEEE-519 standard. The approval of the proposed MPPT controller is appeared by MATLAB/SIMULINK reproduction.
Comparison of Hypertension in Migrant and Local Patients with Atherosclerotic Diseases: A Cross-Sectional Study in Shanghai, China

Background: Hypertension and its complications represent major health problems worldwide and are distributed differently in different populations. This study aimed to reveal the differences between two populations of patients with hypertension who had atherosclerotic complications: local residents in and migrants to the city of Shanghai, China. Methods: We conducted a cross-sectional study among hospitalized patients with hypertension age 21–65 years in Pudong District. We compared the characteristics of local and migrant patients with hypertension, and analyzed the distribution and risk factors of atherosclerotic complications between these groups. Results: The proportion of young and uninsured patients with hypertension was higher among migrant than local participants. The rates of stroke (15.4% vs. 25.0%, p < 0.05) and coronary heart disease (8.6% vs. 11.7%, p < 0.05) were lower and the rates of other atherosclerotic diseases higher (8.5% vs. 7.9%, p = 0.429) among migrant than local participants. According to logistic regression analysis, age was an important risk factor in both the migrant and local groups for all three atherosclerotic complications investigated. Insurance, diabetes, and frequency of hospitalization could influence the incidence of atherosclerotic complications among local patients with hypertension. Among migrant patients, differences for sex, insurance, marital status, diabetes history, and frequency of hospitalization were not significant. Conclusions: Our study demonstrated differences in the characteristics, distribution, and risk factors of atherosclerotic complications among migrant and local patients with hypertension. Greater attention in needed for the increasing population of migrants.