Miracle-dz/UniFAR-FTUs huggingface dataset:
Robust, Automated Analysis of Electrophysiology in Induced Pluripotent Stem Cell-Derived Micro-Heart Muscle for Drug Toxicity.

Drugs are often removed from clinical trials or market progression owing to their unforeseen effects on cardiac action potential and calcium handling. Induced pluripotent stem cell-derived cardiomyocytes and tissues fabricated from these cells are promising as screening tools for early identification of these potential cardiac liabilities. In this study, we describe an automated, open-source MATLAB-based analysis software for calculating cardiac action potentials and calcium transients from fluorescent reporters. We first identified the most robust manner in which to automatically identify the initiation point for action potentials and calcium transients in a user-independent manner, and used this approach to quantify the duration and morphology of these signals. We then demonstrate the software by assessing changes to action potentials and calcium transients in our micro-heart muscles after exposure to hydroxychloroquine, an antimalarial drug with known cardiac liability. Consistent with clinical observations, our system predicted mild action potential prolongation. However, we also observed marked calcium transient suppression, highlighting the advantage of testing multiple physiologic readouts in cardiomyocytes rather than relying on heterologous overexpression of single channels such as the human ether-a-go-go-related gene channel. This open-source software can serve as a useful, high-throughput tool for analyzing cardiomyocyte physiology from fluorescence imaging. Impact statement This article describes an open-source code that will allow researchers to assess changes in cardiac action potentials and calcium transients from fluorescent reporters in a fully automated manner. Automated analysis will allow researchers to increase the throughput of their experiments and grant greater insight into cardiac electrophysiology. Here, the usefulness of these pipelines is demonstrated through analysis of the effects of hydroxychloroquine.
Force and Torque Characterization in the Actuation of a Walking-Assistance, Cable-Driven Exosuit

Soft exosuits stand out when it comes to the development of walking-assistance devices thanks to both their higher degree of wearability, lower weight, and price compared to the bulkier equivalent rigid exoskeletons. In cable-driven exosuits, the acting force is driven by cables from the actuation system to the anchor points; thus, the user’s movement is not restricted by a rigid structure. In this paper, a 3D inverse dynamics model is proposed and integrated with a model for a cable-driven actuation to predict the required motor torque and traction force in cables for a walking-assistance exosuit during gait. Joint torques are to be shared between the user and the exosuit for different design configurations, focusing on both hip and ankle assistance. The model is expected to guide the design of the exosuit regarding aspects such as the location of the anchor points, the cable system design, and the actuation units. An inverse dynamics analysis is performed using gait kinematic data from a public dataset to predict the cable forces and position of the exosuit during gait. The obtained joint reactions and cable forces are compared with those in the literature, and prove the model to be accurate and ready to be implemented in an exosuit control scheme. The results obtained in this study are similar to those found in the literature regarding the walking study itself as well as the forces under which cables operate during gait and the cable position cycle.
Impact of a quality improvement intervention on provider adherence to recommended standards of care for adults with type 2 diabetes mellitus

Purpose: To report provider adherence to standards of care for adults with type 2 diabetes before and after a quality improvement (QI) intervention. Data sources: Pre‐ and post intervention data were abstracted from 50 medical records of patients with type 2 diabetes in a small primary care practice. Conclusion: There was a significant increase in the rates of foot and urine microalbumin screenings, documentation for dilated eye exams were not statistically significant. These findings demonstrated the effectiveness of using simple practice aids to reinforce adherence to the standards of care in diabetes. The failure to see a corresponding improvement in glycemic and blood pressure control is consistent with prior research and the need for more research in this area remain critical. Implications for practice: Ethnic minorities are more likely to have worse control of their diabetes and more likely to receive all their care in the primary care setting, QI interventions targeting primary care providers have the potential to reduce disparities in diabetes care. Future research to determine whether cultural tailoring of diabetes QI interventions will produce additional benefits above those of generic diabetes QI interventions are needed.
Towards Convolutional Neural Network Acceleration and Compression Based on Simon k-Means

Convolutional Neural Networks (CNNs) are popular models that are widely used in image classification, target recognition, and other fields. Model compression is a common step in transplanting neural networks into embedded devices, and it is often used in the retraining stage. However, it requires a high expenditure of time by retraining weight data to atone for the loss of precision. Unlike in prior designs, we propose a novel model compression approach based on Simon k-means, which is specifically designed to support a hardware acceleration scheme. First, we propose an extension algorithm named Simon k-means based on simple k-means. We use Simon k-means to cluster trained weights in convolutional layers and fully connected layers. Second, we reduce the consumption of hardware resources in data movement and storage by using a data storage and index approach. Finally, we provide the hardware implementation of the compressed CNN accelerator. Our evaluations on several classifications show that our design can achieve 5.27× compression and reduce 74.3% of the multiply–accumulate (MAC) operations in AlexNet on the FASHION-MNIST dataset.
Performance evaluation of FinFETs: From multisubband BTE to DD calibration

This paper presents a hierarchical approach to link the advanced multisubband Boltzmann transport equation (MSBTE) solver to the conventional drift-diffusion (DD) model for performance evaluation of non-planar transistors in logic technology development. An automated, physics-based procedure to extract the DD model parameter set from the MSBTE simulation is described. An update on the surface roughness scattering model valid for finite barriers is also shown. As an application, the MSBTE to DD calibration is performed for a silicon nanowire transistor. The calibrated parameter set is applied to a dual channel nanowire transistor, and the effects of the source/drain series and contact resistances are studied.
Association of rs2274907 polymorphism of omentin gene with type 2 diabetes in Iranian population

Background: Diabetes is one of the most common chronic metabolic diseases in the world that is caused by decreased insulin secretion or insulin resistance and fat accumulation in visceral adipose tissue (IR). Omentin is a protein inferred from adipose tissue that is associated with the rate of diabetes. The aim of this study was to investigate the relationship between rs2274907 polymorphism of amentine-1 gene with diabetes. Materials and methods: This case-control study was conducted on 70 patients with diabetes and 70 healthy individuals as control. FBS, TG, CHOL, HDL, and LDL were measured in the subjects and genotype determination was performed using PCR-RFLP. Results: Age, body mass index, LDL, cholesterol, triglyceride, fasting high sugar and insulin resistance were significantly different between patients and healthy individuals (p<0.05). No significant difference was observed in omentin level in diabetic compared to control patients (p>0.05). Omentin levels in different genotypes rs2274907 were different in healthy subjects, but the difference was not significant. Omentin levels in different genotypes rs2274907 were different in healthy subjects (p<0.05). Genotype regression analysis showed that genotypes in rs2274907 polymorphism were not related to diabetes (p>0.05). Conclusion: This study revealed that there was no significant relationship between rs2274907 genotype and type 2 diabetes.
RECIPIENT PRETRANSPLANT INOSINE MONOPHOSPHATE DEHYDROGENASE ACTIVITY IN NONMYELOABLATIVE HCT

Mycophenolic acid, the active metabolite of mycophenolate mofetil (MMF), inhibits inosine monophosphate dehydrogenase (IMPDH) activity. IMPDH is the rate-limiting enzyme involved in de novo synthesis of guanosine nucleotides and catalyzes the oxidation of inosine 5’-monophosphate (IMP) to xanthosine 5’-monophosphate (XMP). We developed a highly sensitive liquid chromatography–mass spectrometry method to quantitate XMP concentrations in peripheral blood mononuclear cells (PMNC) isolated from the recipient pretransplant and used this method to determine IMPDH activity in 86 nonmyeloablative allogeneic hematopoietic cell transplantation (HCT) patients. The incubation procedure and analytical method yielded acceptable within-sample and within-individual variability. Considerable between-individual variability was observed (12.2-fold). Low recipient pretransplant IMPDH activity was associated with increased day +28 donor T-cell chimerism, more acute graft-versus-host disease (GVHD), lower neutrophil nadirs, and more cytomegalovirus reactivation, but not with chronic GVHD, relapse, non-relapse mortality, or overall mortality. We conclude that quantitation of the recipient’s pretransplant IMPDH activity in PMNC lysate could provide a useful biomarker to evaluate a recipient’s sensitivity to MMF, but confirmatory studies are needed. Further trials should be conducted to confirm our findings and to optimize postgrafting immunosuppression in nonmyeloablative HCT recipients.
Understanding value change

The possibility of value change has implications for how to responsibly develop and deploy new technologies. If values can, and do, change after technologies have been developed and designed, this would seem to have major ramifications for approaches such as value-sensitive design and responsible innovation. This contribution explores descriptive as well as normative accounts of value change. It suggests three methodological principles that descriptive accounts of value change should meet. Normative accounts are relatively independent of descriptive accounts and raise the important question of whether normative or moral values themselves can also change. Through the example of the birth control pill and its (alleged) effect on sexual morality, the article illustrates what descriptive and normative accounts might look like in a concrete case. It closes with a discussion of implications for responsibly developing new technologies and draws some conclusions for more theoretical work on value change.
Fake News Detection in Social Networks using Machine Learning: A Review

Fake News is spreading so rapidly these days. This is low-quality news that is generated to targeted someone. This could be created for financial gain or political gain. In no time, millions of tweets are generated and that could be false, people start believing in fake news when there is not enough information available to examine whether the information or the tweet that has been created is true or false and also people start believing in the information that they hear frequently and that could be false. It has been continuing since traditional media but now it is easier in social media to share or comment on such false information. With the growth of this false news or information, it is impossible to manually filter such news. So, there is some computational approach to recognize fake news with different Machine Learning Algorithms like SVM, Naïve Bayes, etc. This review paper mentioned different types of techniques required to detect hoax news. Also discussed different methods used in existing models with their accuracy.
Cancer Cell Plasticity in Urothelial Carcinoma: When it Give Rise to Melanoma

Primary bladder melanoma is very rare, and the association with urothelial carcinoma has never been described to date. We report a case of a biphasic tumor of the bladder, composed of high grade urothelial carcinoma adjacent to melanoma, characterized using immunohistochemistry and DNA sequencing. The urothelial component was positive for pan-cytokeratin and GATA3, and negative for melanoma markers HMB45, Melan A, and Sox10. In contrast, the melanocytic component was negative for pancytokeratin and positive for HMB45, Melan A, and Sox10. Moreover, some nuclei were weakly stained for GATA3, a transcription factor of the urothelial lineage. Molecular genetic analysis showed that both components shared a never described identical serine/threonine kinase 11 (STK11) D365G molecular alteration, and a c. -124C>T Telomerase Reverse Transcriptase (TERT) promoter mutation, an early event in urothelial carcinogenesis. Our report underlines the phenotypic plasticity of urothelial Arch Clin Med Case Rep 2022; 6 (3): 459-465 DOI: 10.26502/acmcr.96550498 Archives of Clinical and Medical Case Reports 460 carcinomas, and raises the question of an urothelial origin of urinary tract melanomas.
Resultados Precoces do Procedimento de Norwood em um Centro de Referência no Brasil

Resumo Fundamento Apenas dois artigos abordam os resultados precoces de pacientes com síndrome do coração esquerdo hipoplásico (SHCE) submetidos à operação de Norwood, no Brasil. Objetivos Avaliamos pacientes com SHCE submetidos ao primeiro estágio da operação de Norwood para identificar os fatores preditivos de mortalidade precoce (nos primeiros 30 dias após a cirurgia) e intermediária (desde a sobrevida precoce até o procedimento de Glenn). Métodos Foram incluídos pacientes com SHCE submetidos em nosso serviço ao primeiro estágio da operação de Norwood de janeiro de 2016 a abril de 2019. Dados demográficos, anatômicos e cirúrgicos foram analisados. Os desfechos foram mortalidade precoce (nos primeiros 30 dias após a cirurgia), mortalidade intermediária (desde a sobrevida precoce até o procedimento de Glenn) e a necessidade de suporte pós-operatório com ECMO. Foram realizadas análises univariadas e multivariadas e calculados odds ratios, com intervalos de confiança de 95%. Um valor de p < 0,05 foi considerado estatisticamente significativo. Resultados Um total de 80 pacientes com SHCE foram submetidos ao primeiro estágio da operação de Norwood. A taxa de sobrevida em 30 dias foi de 91,3% e a taxa de sobrevida intermediária foi de 81,3%. Quatorze pacientes (17,5%) necessitaram de suporte com ECMO. Menor peso (p=0,033), estenose aórtica (vs atresia aórtica; p=0,036) e necessidade de suporte pós-operatório com ECMO (p=0,009) foram fatores preditivos independentes para mortalidade em 30 dias. A estenose da valva mitral ( vs atresia da valva mitral; p=0,041) foi um fator preditivo independente para mortalidade intermediária. Conclusão O presente estudo inclui a maior coorte brasileira de pacientes com SHCE submetidos ao primeiro estágio da operação de Norwood na era recente. Nossas taxas de sobrevida foram comparáveis às mais altas taxas de sobrevida relatadas globalmente. Baixo peso corporal, estenose valvar aórtica e necessidade de suporte pós-operatório com ECMO foram preditores independentes para mortalidade em 30 dias. A estenose da valva mitral foi o único fator preditivo independente para mortalidade intermediária.
Nutritional composition and phytochemical screening in different parts of Hibiscus syriacus L.

Abstract As the national flower of Korea, the Hibiscus syriacus L. (Rose of Sharon) is symbolic in its abundance and is a prominent feature of Korean culture. H. syriacus has played an important role in Korea, not only as an ornamental plant but also as an essential ingredient in folk remedies through its various parts. This study aimed to characterize the nutritional and biochemical composition of each plant unit of H. syriacus “Wonhwa. ” The units are namely: the petals, leaves, roots, and sprouts from its seeds. According to the results each unit produced, the sprouts had the highest content of amino acids and fatty acids which adhere to the requirements of nutritionally excellent food ingredients. The petals produced high quantities of glucose, sucrose, and fumaric acid, with the highest antioxidant activity among the four units. The main bioactive compounds detected in H. syriacus extracts in the four units were o‐coumaric acid, p‐coumaric acid, schaftoside, isoschaftoside, apigenin‐6‐C‐glucoside‐7‐o‐glucoside, and kaempferol‐3‐O‐galactoside‐7‐O‐rhamnoside. Overall, the highest number of bioactive compounds, 2 phenolic acids and 22 flavonoids, were identified in the petals. These results suggest the possibility of excellent pharmacological activity in the petals.
Effect of Lemon Oil Concentrate Cymbopogon citratus ERILIM® towards the Helicobacter pylori Bacteria: A Case Report

This research is based on the effect of the lemon tea concentrate whose polyphenols are powerful antioxidants. Studies have shown that they suppress free radicals in a more effective way than vitamins C or E; in some of cases, specifically in H. pylori, which generally colonizes the human stomach as a single strain with stable characteristics. Authors mention that this colonization can be stable throughout life. This bacterium is related to chronic gastritis, and although H. pylori infection is still the main cause of duodenal and gastric ulcers, the prevalence of ulcers associated with H. pylori is decreasing, while that of related ulcers with non-steroidal anti-inflammatory drugs (NSAIDs) is increasing. Much of what has been published lately about H. pylori and has focused on its important changes in the pattern of the disease and in the potential value of eradication therapy.
Molecular identification of Calliphoridae (Diptera: Calliphoridae) of forensic importance in Colombia

Recognizing the importance of the correct identification of insects associated with deceased bodies for an effective estimation of time of death, and taking into account the incidence of flies of the family Calliphoridae in corpses and the difficulty of their taxonomic determination, we evaluated the usefulness of COI mitochondrial gene sequences as a molecular diagnostic tool for identifying forensically important calliphorids in Colombia. Sequences obtained from samples collected in different regions of Colombia and other sequences taken from Genbank were used. Based on the genetic distances calculated using the K2P model, nucleotide divergence and neighbour-joining analyses were performed. Bayesian analyses were also developed and a graphical representation of the variation of the COI fragments for each species. A total 545 pb fragments were obtained; the values of intraspecific distance when all sequenced were included, ranged between 0% and 2.904% and the interspecific distance ranged between 0.188% and 18.07%, with an overlapping distance, caused mostly by the inclusion of species with only one sequence. When we excluded species with a single sequence and L. eximia was analyzed as two subgroups, a distance gap of 2.292% was obtained, which is an optimal value for the validation of this technique. Reciprocal monophyly was observed in most species. We conclude that the COI gene is a good marker for delineating species of the family Calliphoridae in Colombia.
Cost-Benefit Analysis of Business Improvement District

The purpose of this paper is to clarify the cost-benefit of Business Improvement District (BID), intended to promote local economy and community. The BID of Flatiron District in New York City receives the levy ($0.1/sf annually) from commercial property owners. In order to verify the validity of levy, this paper uses the Hedonic Approach and calculates the rent gap inside BID and outside it. The results showed that the office rent inside BID is $0.9/sf (1.4%) higher than that of outside BID, and the retail rent exceeds that of outside BID by $1.0/sf (0.7%). On the other hand, the apartment rent gap is the larger than others and estimated to $234/unit (7.4%) in spite of paying only $0.1 per building. Therefore, further discussion is needed for setting the levy level for each building uses and how to keep the balance between cost and benefit of BID.
Review of low‐temperature lithium‐ion battery progress: New battery system design imperative

Lithium‐ion batteries (LIBs) have become well‐known electrochemical energy storage technology for portable electronic gadgets and electric vehicles in recent years. They are appealing for various grid applications due to their characteristics such as high energy density, high power, high efficiency, and minimal self‐discharge. LIBs may now theoretically be tailored for a variety of operating circumstances and applications because of the ability to change the material properties of the electrodes and electrolytes. However, LIBs operating at low temperatures have significantly reduced capacity and power, or even do not work properly, which poses a technical barrier to market entry for hybrid electric vehicles, battery electric vehicles, and other portable devices. This review summarizes the state‐of‐art progress in electrode materials, separators, electrolytes, and charging/discharging performance for LIBs at low temperatures. Due to the sluggish kinetics, insufficient ionic conductivity at low temperatures, and sluggish desolvation, it became challenging to enhance the electrochemical performance of LIBs at reduced temperatures. This review recommends approaches to optimize the suitability of LIBs at low temperatures by employing solid polymer electrolytes (SPEs), using highly conductive anodes, focusing on improving commercial cathodes, and introducing lithium‐rich materials into separators. Finally, we propose an integrated electrode design strategy to improve low‐temperature LIB performance.
Innovation of e-commerce marketing model under the background of big data and artificial intelligence

With the advent of the era of big data and artificial intelligence, e-commerce enterprises have used a large number of advanced technologies and knowledge management methods to improve work efficiency. In the context of e-commerce, the innovation of enterprise marketing management model has become one of the important contents of the company’s business development in the e-commerce era. Focusing on the core concept of “e-commerce marketing model innovation”, this paper conducts a comprehensive and systematic research on the e-commerce marketing model innovation of enterprise e-commerce, and focuses on the two aspects of e-commerce marketing model innovation and e-commerce model performance evaluation. The purpose of this paper is to understand the importance of innovation factors in the innovation of e-commerce marketing models through questionnaires, so as to provide new ideas for the innovation path of e-commerce marketing models. This paper adopts the questionnaire survey method and data analysis method. According to the survey results, 39, 31, 33, and 35 of the respondents believe that market positioning, business strategy, marketing promotion, and operation management should be prioritized as innovative elements, among which market positioning accounts for a relatively high proportion, followed by operation management. It can be seen that most of the respondents believe that in order to innovate the marketing model of e-commerce, we must start from the aspects of market positioning, business strategy, marketing promotion, and operation management. Combined with the era background and related content of big data and artificial intelligence, this paper studies e-commerce and marketing models, so as to provide new ideas for the innovative path of e-commerce marketing models.