Miracle-dz/UniFAR-FTUs huggingface dataset:
with Immunoglobulin (Ig) (cid:2) Immunoreceptor Tyrosine–based Activation Motif (ITAM) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Ig (cid:3) Cytoplasmic Tail

To determine the function of immunoglobulin (Ig) (cid:2) immunoreceptor tyrosine–based activation motif (ITAM) phosphorylation, we generated mice in which Ig (cid:2) ITAM tyrosines were replaced by phenylalanines ( Ig (cid:2) FF/FF ). Ig (cid:2) FF/FF mice had a specific reduction of B1 and marginal zone B cells, whereas B2 cell development appeared to be normal, except that (cid:4) 1 light chain usage was increased. The mutants responded less efficiently to T cell–dependent antigens, whereas T cell–independent responses were unaffected. Upon B cell receptor ligation, the cells exhibited heightened calcium flux, weaker Lyn and Syk tyrosine phosphorylation, and phosphorylation of Ig (cid:2) non-ITAM tyrosines. Strikingly, when the Ig (cid:2) ITAM mutation was com-bined with a truncation of Ig (cid:3) , B cell development was completely blocked at the pro-B cell stage, indicating a crucial role of ITAM phosphorylation in B cell development. and immunoblotted with anti-phosphotyrosine antibody Py54 (Cal-biochem), followed by horseradish peroxidase (HRP)-conju-gated rat anti–mouse IgG (Amersham Pharmacia Biotech) and developed by chemiluminescence (ECL; Amersham Pharmacia Biotech). To determine the amount of protein loaded in each lane, the same membranes were stripped and reprobed with appropriate antibodies.
Information Flow and Entropy Production on Bayesian Networks

In this article, we review a general theoretical framework of thermodynamics of information on the basis of Bayesian networks. This framework can describe a broad class of nonequilibrium dynamics of multiple interacting systems with complex information exchanges. For such situations, we discuss a generalization of the second law of thermodynamics including information contents. The key concept here is an informational quantity called the transfer entropy, which describes the directional information transfer in stochastic dynamics. The generalized second law gives the fundamental lower bound of the entropy production in nonequilibrium dynamics, and sheds modern light on the paradox of "Maxwell's demon" that performs measurements and feedback control at the level of thermal fluctuations.
Surface modi�cation of magnesium oxide/epoxy composites with signi�cantly improved mechanical and thermal properties

This paper demonstrated the effect of functionalized magnesium oxide (MgO) nanoparticles with 3-(Aminopropyl) triethoxysilane (APTES) as �llers on the mechanical and thermal properties of epoxy composite. The functionalization of MgO (S-MgO) considerably improved the inteface between the MgO and epoxy resin. The mechanical properties of the composites revealed that the addition of functionalized MgO improved their tensile strength, modulus of elasticity, and ductility when compared to neat epoxy. In compare to neat epoxy, the in-plane thermal conductivity of the epoxy composite with S-MgO �ller improved by 10 folds. These observations indicated that the silane functionalization on MgO contributes to the formation of a strong interfacial bond and a compact interconnected network between the �ller and the epoxy matrix.
Knowledge transfer between projects

Title: Knowledge transfer between projects – Exploring the receiver’s perspective Authors: Nathalie Haglund and Frida Wåhlberg Supervisor: Karin Bredin Background: How to facilitate the knowledge transfer between projects is a field that has obtained a lot of attention in research. Despite this wide attention, many organizations still experience difficulties to efficiently transfer knowledge between their projects and thus the problems still remain, which appears contradictory. Previous research has had a tendency to assume that all knowledge can be articulated and codified, which has resulted in that solutions to these problems often have been directed towards the side in the transfer that creates the supply of knowledge. However, limited research has taken the receiver of the knowledge into consideration when analyzing these difficulties, who is considered to be equally influential to motivate a transfer. Purpose: The purpose of this study is to increase the understanding of the challenges concerning the knowledge transfer from past to future projects, by exploring the importance of incorporating the receiver’s perspective in the analysis of knowledge transfer practices. Methodology: This study has applied a qualitative research methodology where the empirical data has been obtained through an interview-study with nine onsite interviews in two different firms, ABB and SIEMENS. Furthermore, documents were studied in order to compliment and increase the understanding of the information provided in the interviews. Conclusions: By incorporating the receiver in the analysis we can conclude that the practices applied are not efficient in actually transferring the complete knowledge. Herewith, socialization becomes vital as a complement to these practices in order to also transfer the ‘hidden’ explicit knowledge as well as tacit knowledge that the receiver is in need of. The findings thus demonstrate the importance of taking the nature of knowledge into account when investigating the challenges with current knowledge transfer practices.
11(78-87)(완료)E15214 ed-Ranjeet Kumar.hwp

Red blood cells (RBCs) are customarily adhered to a bio-functionalised substrate to make them stationary in interferometric phase-imaging modalities. This can make them susceptible to receive alterations in innate morphology due to their own weight. Optical tweezers (OTs) often driven by Gaussian profile of a laser beam is an alternative modality to overcome contact-induced perturbation but at the same time a steeply focused laser beam might cause photo-damage. In order to address both the photo-damage and substrate adherence induced perturbations, we were motivated to stabilize the RBC in OTs by utilizing a laser beam of ‘arbitrary intensity profile’ generated by a source having cavity imperfections per se. Thus the immobilized RBC was investigated for phase-imaging with sinusoidal interferograms generated by a compact and robust Michelson interferometer which was designed from a cubic beam splitter having one surface coated with reflective material and another adjacent coplanar surface aligned against a mirror. Reflected interferograms from bilayers membrane of a trapped RBC were recorded and analyzed. Our phase-imaging set-up is limited to work in reflection configuration only because of the availability of an upright microscope. Due to RBC’s membrane being poorly reflective for visible wavelengths, quantitative information in the signal is weak and therefore, the quality of experimental results is limited in comparison to results obtained in transmission mode by various holographic techniques reported elsewhere.
Can high-energy γ-ray photons escape from the radiation field emitted by an accretion disk?

The optical depth for the high energy γ-ray photons on the anisotropic thermal radiation field, emitted by the accretion disk around a compact object, is computed. The γ-ray photons are assumed to originate in the collisions of relativistic hadrons with matter entrained in the disk as postulated by some models of the γ-ray production in X-ray binary systems. We predict that the γ-ray telescopes designed to work in the energy range between a few GeV and ∼0.1 TeV (solar One, EGRET) may have serious problems with the detection of some X-ray binaries (e.g. Her X-1, Cen X-3), even if they are already positively detected in the TeV energy range. However, in the case of other X-ray binaries, similar to Vela X-1, the discussed process is negligible
Acquiring Legal Ontologies from Domain-speciﬁc Texts

The paper reports on methodology and preliminary results of a case study in automatically extracting ontological knowledge from Italian legislative texts in the environmental domain. We use a fully-implemented ontology learning system (T2K) that includes a battery of tools for Natural Language Processing (NLP), statistical text analysis and machine language learning. Tools are dynamically integrated to provide an incremental representation of the content of vast repositories of unstructured documents. Evaluated results, however preliminary, are very encouraging, showing the great potential of NLP-powered incremental systems like T2K for accurate large-scale semi– automatic extraction of legal ontologies
The Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC)

Endorsed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and by the International Society of Chemotherapy (ISC) for Infection and Cancer Authors/Task Force Members: Gilbert Habib (Chairperson) (France)*, Bruno Hoen (France), Pilar Tornos (Spain), Franck Thuny (France), Bernard Prendergast (UK), Isidre Vilacosta (Spain), Philippe Moreillon (Switzerland), Manuel de Jesus Antunes (Portugal), Ulf Thilen (Sweden), John Lekakis (Greece), Maria Lengyel (Hungary), Ludwig Müller (Austria), Christoph K. Naber (Germany), Petros Nihoyannopoulos (UK), Anton Moritz (Germany), Jose Luis Zamorano (Spain)
Evolution of dynamical facilitation approaching the granular glass transition

We investigate the relaxation dynamics of a dense monolayer of bidisperse beads by analyzing the experimental data previously obtained in a fluidized bed. We show that the dynamics is formed by elementary relaxation events called cage jumps. These aggregate on a very short time into clusters. Increasing the packing fraction makes the spatio-temporal organization of the clusters evolve from a rather scattered and random distribution towards a collection of sparse and large events, called avalanches. The avalanche process is a manifestation of dynamical facilitation. The study of its evolution with density reveals that dynamical facilitation becomes less conserved and play a lesser role for the structural relaxation approaching the granular glass transition.
Multimodal Approach to Emotion Recognition for Enhancing Human Machine Interaction - A Survey

Emotions are defined as a mental state that occurs instinctively rather than through voluntary effort. They are strong feelings triggered by experiencing the joy, hate, fear, love and is followed by some physiological changes. Emotions play a vital role in social interactions and facilitate the decision making and perception in human being. Emotions are conveyed through speech, facial expression or by physiological signals. There are 6 emotions which are treated as universal emotions: anger, happiness, sadness, disgust, surprise and fear. This paper projects different emotion recognition systems which aim at enhancing the Human-Machine interaction. The techniques and systems used in emotion detection may vary depending on the features inspected. This paper explores them in a descriptive and comparative manner. Further the various applications that adopt these systems to reduce the difficulties in implementing the models in real-time are contemplated . Also, A multimodal system with both speech and facial features is proposed for emotion recognition through which it is possible to obtain an enhanced accuracy compare with the existing systems.
Analysis and application of subdivision surfaces

Subdivision surfaces are a convenient representation for modeling objects of arbitrary topological type. In this dissertation, we investigate the analysis of a piecewise smooth subdivision scheme, and we apply the scheme to reconstruct objects from non-uniformly sampled data points. Defined as the limit of repeated refinement of a mesh of 3D control points, subdivision surfaces require analysis to establish convergence to a well-defined, tangent plane smooth $(G\sp1)$ surface. Recent research has focused on analyzing smooth surface schemes in which the rules are symmetrical about each vertex and edge. However, a scheme for creating surfaces with sharp features has rules that do not exhibit this symmetry. In this dissertation, we extend the use of eigenanalysis and characteristic maps to analyze a piecewise smooth subdivision scheme that generalizes quartic triangular B-spline surfaces. Subdivision surfaces are suitable for optimized surface fitting and have been used in the reconstruction of objects from 3D data. Previous methods have created accurate representations of objects from dense and uniform data samples. As a practical low cost alternative, we present an algorithm for creating a subdivision surface from data sampled uniformly along closed curves and non-uniformly within the regions they enclose.
Study on screening and evaluation methods of cosmetics for people with facial sensitive skin

Objective: The purpose of this study is to screen and evaluate cosmetic products for sensitive skin on the face. Methods: Thirty-five subjects with positive lactic acid sting test (LAST) were recruited from the staff of our hospital from November 2019 to February 2020. First, the human skin enclosed patch test of cosmetic gel (abbreviated as gel) was performed, and then the tested products were continuously applied for 4 weeks to complete the long-term efficacy test. Subjects’ sensation of application, pruritus, tingling and burning were assessed on a 0 to 9 scale prior to, 14, and 28 days after topical application. Moreover, the transepidermal water loss rate (TEWL), stratum corneum (SC) hydration, melanin index (MI), erythema index (EI) and dendritic cells and inflammatory cell infiltration were noninvasively detected by the tester. LAST were performed before applying, 14 and 28 days after application, and then the test results were compared. Results: In this study, a total of 34 people participated in the test. The results of human skin enclosed patch test indicated that only 1 case of grade 1 reaction occurred among the tested subjects. The subjects felt good after applying the products, and the gel showed high degree of skin comfortable, no irritation and good tolerability. Subjective safety evaluation illustrated that the scores of pruritus, tingling and burning of the subjects decreased in D14 and D28 patient revisit, showing statistically significant differences (P < .05). When the gel was applied for 4 weeks, TEWL (8.42 ± 1.12) and EI (201.35 ± 13.51) were lower than the results before application (P < .05), and the SC hydration (65.36 ± 2.56) was higher than that before application (P < .05). There was no correlation between the SC hydration and TEWL (R = 0.092, P = .416). The results of skin CT indicated that the number of facial dendritic cells decreased in 17 subjects (accounting for 50%) in D28 patient revisit, and the degree of inflammatory cell infiltration decreased in 27 subjects (accounting for 80%). Compared with the baseline value, the LAST score and total sensory score decreased after application the product for 4 weeks, and the difference was statistically significant (the mean value of P < .05). Conclusion: The subjective feeling of application and efficacy of cosmetics in people with sensitive skin could be successfully evaluated by the comprehensive application of human skin enclosed patch test, long-term trial test, subjective safety evaluation and objective efficacy evaluation. And it provides the basis to judge whether the cosmetic is consistent with the efficacy claim of sensitive skin.
SARS‐CoV‐2 and mutation RT‐qPCR test positivity correlation with ABO and Rh blood types

Studies show that there may be a relationship between ABO blood type and SARS‐CoV‐2 transmission. It was aimed to determine by investigating the blood type of patients whose one‐step reverse transcription and real‐time polymerase chain reaction (RT‐qPCR) test were positive for SARS‐CoV‐2. ABO and Rh blood types of individuals whose RT‐qPCR test was positive for SARS‐CoV‐2 were examined and an evaluation was made to identify whether there was a relationship between them or not. The blood type data of 44.928 SARS‐CoV‐2 positive RT‐qPCR test results have been obtained. 17.656 (39.29%) were delta, 8048 (17.91%) were alpha, 800 (1.78%) were beta, and 3000 (6.67%) were omicrons while 15.424 (34.33%) SARS‐CoV‐2 positive mutation was found to be negative. Our study suggests that O and Rh (−) blood types may provide protection against delta, AB and Rh (+) blood types may hinder omicron infection while A and Rh (+) blood types may be more vulnerable to alpha and delta while B and Rh (+) are more sensitive to beta mutation. The molecular mechanism underlying the relationship between blood types and SARS‐CoV‐2 infection needs further molecular studies and multi‐centered studies.
A cross sectional study of nurses' perceptions of nurse leaders' internal crisis communication during the COVID‐19 pandemic

Abstract Aim The aim of this study is to describe nurse perceptions of nurse leaders' internal crisis communication during the COVID‐19 pandemic. Background Internal communication is a vital part of nurse leaders' work, even more so during crises such as the COVID‐19 pandemic. Method This is a cross‐sectional study design. The data were collected from 204 Finnish nurses in February 2021. A questionnaire developed in this study consisted of 29 items measuring internal crisis communication and seven demographic variables. The relationships between the variables were examined with cross‐tabulation, a chi‐squared test and non‐parametric tests. Factor structure was evaluated with exploratory factor analysis and reliability with Cronbach's alpha. Results Nurses perceived the timeliness of communication highest and interaction the lowest. Nurses from intensive care, acute care and operative rooms gave highest evaluations for the content of communication and timeliness. Nurses working with COVID‐19 patients daily or weekly evaluated the highest level of false communication. Conclusion Nurse leaders' internal crisis communication was timely, especially in the most critical units dealing with the pandemic. The study highlighted the importance of considering a unit's special needs for internal crisis communication. Interaction between nurse leaders and nursing staff during periods of crisis needs improvement. Implications for Nursing Management Nurse leaders' successful and emphatic communication is important in supporting nurses in managing a crisis.
The magical smell and taste: Can coffee be good to patients with cardiometabolic disease?

Abstract Coffee is a beverage consumed globally. Although few studies have indicated adverse effects, it is typically a beneficial health-promoting agent in a range of diseases, including depression, diabetes, cardiovascular disease, and obesity. Coffee is rich in caffeine, antioxidants, and phenolic compounds, which can modulate the composition of the gut microbiota and mitigate both inflammation and oxidative stress, common features of the burden of lifestyle diseases. This review will discuss the possible benefits of coffee on complications present in patients with diabetes, cardiovascular disease and chronic kidney disease, outwith the social and emotional benefits attributed to caffeine consumption.
Characterization of microparticles derived from waste plastics and their bio‐interaction with human lung A549 cells

Microplastics (MPs) represent a worldwide emerging relevant concern toward human and environmental health due to their intentional or unintentional release. Human exposure to MPs by inhalation is predicted to be among the most hazardous. MPs include both engineered, or primary MPs, and secondary MPs, materials obtained by fragmentation from any plastic good. The major part of the environmental MPs is constituted by the second ones that are irregular in size, shape and composition. These features make the study of the biological impact of heterogenous MPs of extremely high relevance to better estimate the real toxicological hazards of these materials on human and environmental organisms. The smallest fractions of plastic granules, relying on the micron‐sized scale, can be considered as the most abundant component of the environmental MPs, and for this reason, they are typically used to perform toxicity tests using in vitro systems representative of an inhalation exposure scenario. In the present work, MPs obtained from industrial treatment of waste plastics (wMPs < 50 μm) were investigated, and after the physico‐chemical characterization, the cytotoxic, inflammatory and genotoxic responses, as well as the modality of wMPs interactions with alveolar lung cells, were determined. Obtained results indicated that, at high concentrations (100 μg/ml) and prolonged exposure time (48 h), wMPs affect biological responses by inducing inflammation and genotoxicity, as a result of the cell–wMP interactions, also including the uptake of the smaller particles.
Hydroethanolic Extracts of Senna alata Leaves Possess Antimalarial Effects and Reverses Haematological and Biochemical Pertubation in Plasmodium berghei-infected Mice

The current work investigated the chemical profile, antimalarial potential and capacity of hydroethanolic Senna alata extract (SAE) to reverse hematological and biochemical pertubation in Plasmodium berghei infected mice. Results of the phytochemical analysis revealed the presence of alkaloids, flavonoids, phenolics, tannins, terpenoids, saponins, steroids and cardiac glycosides. Total phenolic and flavonoid content was estimated to be 45.29 ± 2.34 mg GAE/g and 25.22 ± 2.26 mg QE/g respectively. In vitro analysis of the extract also confirmed its antioxidant property. Results of the test for prophylaxis of P. berghei indicated that SAE suppressed parasitemia significantly in treated groups in a dose dependent manner when compared with negative control group. Similarly, SAE improved the mean survival time (MST) and packed cell volume (PCV) of infected mice. The test for curative effect showed that SAE significantly suppressed parasitemia to 4.50 ± 1.05% compared to untreated group 29.83 ± 3.49%. Results of liver and kidney functions indices of treated animals indicated that whereas infection with P. berghei caused increase in the levels of AST, ALT, ALP, urea and creatinine, treatment with SAE significantly reversed the perturbation. Similarly, infected mice were dyslipidemic with concomitant increased activity of HMG CoA reductase and decreased activity of antioxidant enzymes with increase in lipid peroxides levels. However, these alterations were significantly reversed by administration of SAE. Results of this study shows that Senna alata possess antimalarial activity and therefore justify the traditional use of plant for the treatment of malaria.