Miracle-dz/UniFAR-FTUs huggingface dataset:
A Novel Mouse Model of TGFβ2-Induced Ocular Hypertension Using Lentiviral Gene Delivery

Glaucoma is a multifactorial disease leading to irreversible blindness. Primary open-angle glaucoma (POAG) is the most common form and is associated with the elevation of intraocular pressure (IOP). Reduced aqueous humor (AH) outflow due to trabecular meshwork (TM) dysfunction is responsible for IOP elevation in POAG. Extracellular matrix (ECM) accumulation, actin cytoskeletal reorganization, and stiffening of the TM are associated with increased outflow resistance. Transforming growth factor (TGF) β2, a profibrotic cytokine, is known to play an important role in the development of ocular hypertension (OHT) in POAG. An appropriate mouse model is critical in understanding the underlying molecular mechanism of TGFβ2-induced OHT. To achieve this, TM can be targeted with recombinant viral vectors to express a gene of interest. Lentiviruses (LV) are known for their tropism towards TM with stable transgene expression and low immunogenicity. We, therefore, developed a novel mouse model of IOP elevation using LV gene transfer of active human TGFβ2 in the TM. We developed an LV vector-encoding active hTGFβ2C226,228S under the control of a cytomegalovirus (CMV) promoter. Adult C57BL/6J mice were injected intravitreally with LV expressing null or hTGFβ2C226,228S. We observed a significant increase in IOP 3 weeks post-injection compared to control eyes with an average delta change of 3.3 mmHg. IOP stayed elevated up to 7 weeks post-injection, which correlated with a significant drop in the AH outflow facility (40.36%). Increased expression of active TGFβ2 was observed in both AH and anterior segment samples of injected mice. The morphological assessment of the mouse TM region via hematoxylin and eosin (H&E) staining and direct ophthalmoscopy examination revealed no visible signs of inflammation or other ocular abnormalities in the injected eyes. Furthermore, transduction of primary human TM cells with LV_hTGFβ2C226,228S exhibited alterations in actin cytoskeleton structures, including the formation of F-actin stress fibers and crossed-linked actin networks (CLANs), which are signature arrangements of actin cytoskeleton observed in the stiffer fibrotic-like TM. Our study demonstrated a mouse model of sustained IOP elevation via lentiviral gene delivery of active hTGFβ2C226,228S that induces TM dysfunction and outflow resistance.
Modified nonlinear amplifying loop mirror for mode-locked fibre oscillators with record-high energy and high-average-power pulsed output

The present work proposes and studies approaches for development of new modified non-linear amplifying loop mirror (NALM) allowing flexible and dynamic control of their non-linear properties within a relatively broad range of radiation powers. Using two independently pumped active media in the loop reflector constitutes one of the most promising approaches to development of better NALM with nonlinear properties controllable independently of the intra-cavity radiation power. This work reports on experimental and theoretical studies of the proposed redesigned NALM allowing both a higher level of energy parameters of output generated by mode-locked fibre oscillators and new possibilities of switching among different mode-locked regimes.
Circulating IL-1β, IL-17, and IP-10 as Potential Predictors of Hepatitis B Virus Infection Prognosis

Circulating cytokines and chemokines play critical roles in hepatitis B virus (HBV) infection. Here, we explored the effects of proinflammatory and anti-inflammatory effector molecules on HBV progression, e antigen seroconversion, and liver function. Our results showed that circulating interleukin (IL)-17 may be helpful in HBV spontaneous clearance [odds ratio (OR) = 1.468, 95%confidence interval (CI) = 1.080–1.995, P = 0.014] and protective against HBV-related hepatoma development (OR = 0.933, 95%CI = 0.910–0.957, P < 0.001). IL-1β negatively affected HBV clearance (OR = 0.052, 95%CI = 0.005–0.534, P = 0.013). In patients with chronic hepatitis B, interferon-γ-inducible protein-10 (IP-10) levels significantly increased in the group of abnormal liver function (P = 0.006). Furthermore, positive correlations of IP-10 with alanine aminotransferase and aspartate aminotransferase levels were observed (rs = 0.546 and 0.644, respectively; P < 0.001). In conclusion, inflammatory cytokines and chemokines may be a “double-edged sword” for HBV clearance and progression. Further exploration of the roles of IL-17, IL-1β, and IP-10 in chronic HBV infection is needed.
The role of relational mobility in relationship quality and well-being

This paper examined the associations among: (1) the perceived freedom to initiate and end interpersonal relationships (relational mobility), (2) relationship quality, and (3) well-being. Across 38 nations, people in nations with higher relational mobility reported greater well-being, which was explained by higher-quality relationships with close others (Study 1A). This effect was replicated at the individual level, after controlling for extraversion and socio-economic status (Study 1B). Finally, first-year college students with higher relational mobility reported receiving more social support from new friends during the COVID-19 pandemic, which explained those students’ higher well-being during the pandemic (Study 2). Together, this work demonstrates that relational mobility can explain enhanced well-being across nations, individuals, and life circumstances, and indicates potential avenues for interventions that increase the well-being of individuals and societies.
Factor Structure and Measurement Invariance of the Brief Symptom Inventory-18 Among Chinese Adults

This study aimed to investigate the factor structure and measurement invariance of the Brief Symptom Inventory-18 (BSI-18) among Chinese adults. A sample comprising 1,839 adults from four cities in Shaanxi province completed the BSI-18 and background information. The best-fitting factor structure model of the BSI-18 was verified by confirmatory factor analyses, and multigroup confirmatory factor analyses were performed to test the measurement invariance. The results indicated that the three-factor bi-factor model fitted the current data best (χ2 = 468.861, df = 117, CFI = 0.939, TLI = 0.920, RMSEA = 0.040, BIC = 47044.977). The configural, metric, scalar, and strict invariance models all had acceptable model fit indexes across genders, and the configural, metric, scalar invariance models with different living areas and educational levels were all acceptable. Overall, the three-factor bi-factor model of the BSI-18 shows a good fit for use with Chinese adults, making it a viable tool for effectively measuring the mental health of Chinese adults.
Precrops and N-fertilizer impacts on soybean performance in tropical regions of Brazil

Precrops have different growth patterns, nitrogen (N) requirements, and production of residues varying in amounts and quality that may affect the N-clycling and the soybean (Glycine max L. Merrill) cropped in succession. This study aimed to evaluate the effect of precrops and N fertilization on soybean performance. An experiment was conducted in Londrina, Paraná State, Brazil, with six precrops treatments: fallow, ruzigrass (Urochloa ruziziensis), showy rattlebox (Crotalaria spectabilis), corn (Zea mays) without or with 80 kg ha−1 of N at topdressing as urea, and wheat (Triticum aestivum). Subplots consisted of two levels of N fertilization at soybean sowing: 0 and 30 kg ha−1 of N as ammonium nitrate at sowing. Urochloa ruziziensis as precrops increased the soybean yield (5,171 kg ha-1) when compared with corn (4,346 kg ha-1) and fallow (4,467 kg ha-1). In 2016/17, N fertilization of soybean with 30 kg ha−1 of N at sowing, although increasing the initial plant growth (745 kg ha-1 with vs. 662 kg ha-1 without), impairs nodulation (100 mg pl-1 with vs. 130 g pl-1 without) and does not increase grain yield. Oil and protein concentrations in soybean grains are not influenced by precrops and N fertilization at sowing. We found that the use Urochloa ruziziensis as cover crop in soybean precrops is a good recommendation option in tropical regions of Brazil, because increasing the yield of soybean grown in succession. N fertilization at in soybean sowing it should not be recommended even in the presence of a large amount of straw.
Antibiotic sensitivity testing in subclinical mastitis in Gir Cows

The present investigation on Antibiotic Sensitivity Test of subclinical mastitis in Gir cow was carried out in Udaipur district of Mewar region of Rajasthan. Total of 188 quarter milk samples of milk from the 47 apparently healthy Gir cows were selecteted purposively to study the Antibiotic Sensitivity Test of subclinical mastitis in Gir cows. The antibiotic sensitivity by disc diffusion method using Muellar-Hinton agar the basis of Zone of inhibition. The Antibiogram of isolates revealed sensitivity of different antibiotics to the isolated bacteria was highest for amoxycillin-sulbactam (98 per cent), followed by cefuroxime and cefoperazone (96.36 per cent each). Chloramphenicol and ceftriaxone (90.90 each), ciprofloxacin (74.54 per cent) and tetracyciline (63.63 per cent).
Optimal Sizing and Spatial Allocation of Storage Units in a High-Resolution Power System Model

The paradigm shift of large power systems to renewable and decentralized generation raises the question of future transmission and flexibility requirements. In this work, the German power system is brought to focus through a power transmission grid model in a high spatial resolution considering the high voltage (110 kV) level. The fundamental questions of location, type, and size of future storage units are addressed through a linear optimal power flow using today’s power grid capacities and a generation portfolio allowing a 66% generation share of renewable energy. The results of the optimization indicate that for reaching a renewable energy generation share of 53% with this set-up, a few central storage units with a relatively low overall additional storage capacity of around 1.6 GW are required. By adding a constraint of achieving a renewable generation share of at least 66%, storage capacities increase to almost eight times the original capacity. A comparison with the German grid development plan, which provided the basis for the power generation data, showed that despite the non-consideration of transmission grid extension, moderate additional storage capacities lead to a feasible power system. However, the achievement of a comparable renewable generation share provokes a significant investment in additional storage capacities.
Multi Criteria Decision Making based Approach to Assist Marketers for Targeting BoPs Regarding Packaging Influenced Purchase during Covid-19

This study has a novel approach to capture the attitude of Bottom of the Pyramid (BoP) consumers towards Packaging Influenced Purchase (PIP) during the Covid-19 crisis. Over the years, BoPs consumers have established themselves as an emerging market with ample growth and opportunities. The authors suggested a Multiple-Criteria Decision-Making (MCDM) based framework to assist marketers in targeting both urban and rural BoP consumers regarding PIP. Packaging elements and influence of family, extended family, peers have been included in the framework for gaining in-depth understanding. With a sample size of 100 from West Bengal, this focus group-based study can fulfil the BoP literature’s existing prominent research gap. Results indicate the difference in attitude for urban and rural BoPs towards PIP during this crisis. The fusion of MCDM based approach and relevant machine learning-based technique aims to assist marketers in identifying, formulating, and redefining an action plan.
Exploring the value of feminist theory in understanding digital crimes: Gender and cybercrime types

Do men and women perceive cybercrime types differently? This article draws on the distinction between socio-economic and psychosocial cybercrime proposed by Lazarus (2019) to investigate whether men and women hold different perceptions of digital crimes across these two dimensions. Informed by the synergy between feminist theory and the Tripartite Cybercrime Framework (TCF), our survey examined respondents’ differential perceptions of socio-economic cybercrime (online fraud) and psychosocial cybercrime (cyberbul-lying, revenge porn, cyberstalking, online harassment) among men and women in the United Kingdom. The results revealed that women considered psychosocial cybercrime worse than men. Conversely, we found no differences between men and women with regard to socio-economic cybercrime. The article concludes that psychosocial cybercrimes are more gendered than socio-economic cybercrime, suggesting problems with the meaning of ‘cyber-enabled crimes’, and substan-tiating the synergy between the TCF and feminist perspectives.
Roles of Arbuscular mycorrhizal Fungi as a Biocontrol Agent in the Control of Plant Diseases

Arbuscularmycorrhizal fungi (AMF) are a class of beneficial microorganisms that are widely distributed in soil ecosystems and can form symbionts with 80% of terrestrial higher plants, and improve the nutritional status of plants. The use of AMF as a biocontrol method to antagonize soil-borne pathogens has received increasing interest from phytopathologists and ecologists. In this paper, the mechanisms of resistance to diseases induced by AMF and the application of AMF to plant fungal, bacterial, and nematode diseases have been summarized. This study aimed to enhance the potential use of AMF as a biological control method to prevent plant diseases in the future. Root morphological alteration characteristics were explained, including the influence of AMF on root structure, function, and the regulation of AMF via secondary metabolites. AMF can improve the rhizosphere environment by influencing the physical and chemical proprieties of soil, enhancing the growth of other beneficial microorganisms, and by competing with pathogenic microorganisms. Two microorganism types may compete for the same invasive sites in root systems and regulate nutrition distribution. AMF can induce the host plant to form defense systems, including improving phytohormone concentrations, inducing signal substrate production, gene expression regulation, and enhancing protein production.
Resiliencia en estudiantes varones y mujeres de bachillerato del colegio Manuela Sáenz de Quito – Ecuador, en tiempos de COVID-19

El objetivo de la investigación fue determinar la diferencia del nivel de resiliencia entre estudiantes varones y mujeres de bachillerato del Colegio Manuela Sáenz de la ciudad de Quito-Ecuador en tiempos de COVID-19. El estudio fue de enfoque cualitativo, nivel descriptivo y diseño no experimental, de corte transversal, descriptivo comparativo; la muestra estuvo integrada por 112 estudiantes mujeres y 103 varones de bachillerato. Como instrumento de recolección de datos se aplicó la Escala Breve de Resiliencia. Según resultados, en las mujeres predominó el nivel medio de resiliencia (53,57 %), seguido del nivel alto (35,37 %) y el nivel bajo (10,72 %), mientas que en los varones predominó el nivel bajo de resiliencia (46.61 %), seguido del nivel medio (38,83 %) y nivel alto (14,56 %); se determinó una diferencia significativa entre ambos grupos (p = ,000). En conclusión, se evidencio que significativamente, las estudiantes mujeres tienen un nivel más alto de resiliencia que los estudiantes varones, denotando una mejor capacidad de las mujeres para afrontar las adversidades y frustración en tiempos de COVID-19.
A Study on Performance Improvement of Intrusion Detection using Efficient Authentication and Distributed Monitoring

In a Mobile Ad hoc Network (MANET), mobile nodes play multiple roles as hosts and routers and are dynamically changing multi-hop structures. MANET consists only of wireless nodes with limit processing power, and routing and data transfer are performed through cooperation with each other. It is exposed to many attack threats due to the dynamic topology by the movement of the nodes and the characteristic of multi-hop communication. Therefore, in MANET, a technique that can detect effectively must be applied while detecting malicious nodes and reducing the impact of various attacks. In this paper, we propose an trust based authentication technique for nodes and a distributed monitoring technique to improve the detection performance of malicious nodes. The hierarchical cluster structure was used to improve authentication of nodes and detection performance and management efficiency of malicious nodes. A lightweight authentication technique of member nodes in the cluster was applied and the efficiency of node authentication was improved. It was used to determine whether it was an attack node by transmitting traffic monitoring information for neighbor nodes to CA and using. In addition, the efficient authentication technique using only key exchange without anyone's help was applied in order to provide integrity when exchanging information between cluster heads. Through this, it was possible to be free from trust information about nodes and forgery and falsification of information about attack nodes. The superiority of the technique proposed in this paper was confirmed through comparative experiments with the existing intrusion detection technique.
Adsorption of dimethyl disulfide onto activated carbon cloth

Dimethyl disulfide (DMDS) has a specific unpleasant odour and is profoundly toxic with an odour threshold of around 7–12 ppb. In this study, the removal of DMDS was investigated by adsorption on activated carbon cloth (ACC) in the gas phase. Kinetics and isotherm studies were performed. Adsorption kinetics followed by GC-MS and the data were processed using different models. When correlation coefficients (R2) of linear regression analysis are analyzed, it is seen that the concordance of experimental data to the pseudo-second-order equation is quite good. Isotherm data have been examined using Freundlich, Temkin and Langmuir models. The regression coefficient (R2) of data to fit the Langmuir model is 0.9993, which means that the fit is very good. The monolayer adsorption capacity (qm) of DMDS has been calculated as 118 mL.g−1 according to the Langmuir model.
Moneyball: Proactive Auto-Scaling in Microsoft Azure SQL Database Serverless

Microsoft Azure SQL Database is among the leading relational database service providers in the cloud. Serverless compute automatically scales resources based on workload demand. When a database becomes idle its resources are reclaimed. When activity returns, resources are resumed. Customers pay only for resources they used. However, scaling is currently merely reactive, not proactive, according to customers' workloads. Therefore, resources may not be immediately available when a customer comes back online after a prolonged idle period. In this work, we focus on reducing this delay in resource availability by predicting the pause/resume patterns and proactively resuming resources for each database. Furthermore, we avoid taking away resources for short idle periods to relieve the back-end from ineffective pause/resume workflows. Results of this study are currently being used worldwide to find the middle ground between quality of service and cost of operation.
Carbon–Nitrogen–Sulfur-Related Microbial Taxa and Genes Maintained the Stability of Microbial Communities in Coals

Coal microbes are the predominant form of life in the subsurface ecosystem, which play a vital role in biogeochemical cycles. However, the systematic information about carbon–nitrogen–sulfur (C–N–S)-related microbial communities in coal seams is limited. In this study, 16S rRNA gene data from a total of 93 microbial communities in coals were collected for meta-analysis. The results showed that 718 functional genera were related to the C–N–S cycle, wherein N2 fixation, denitrification, and C degradation groups dominated in relative abundance, Chao1 richness, Shannon diversity, and niche width. Genus Pseudomonas having the most C–N–S-related functions showed the highest relative abundance, and genus Herbaspirillum with a higher abundance participated in C degradation, CH4 oxidation, N2 fixation, ammoxidation, and denitrification. Such Herbaspirillum was a core genus in the co-occurrence network of microbial prokaryotes and showed higher levels in weight degree, betweenness centrality, and eigenvector centrality. In addition, most of the methanogens could fix N2 and dominated in the N2 fixation groups. Among them, genera Methanoculleus and Methanosaeta showed higher levels in the betweenness centrality index. In addition, the genus Clostridium was linked to the methanogenesis co-occurrence network module. In parallel, the S reduction gene was present in the highest total relative abundance of genes, followed by the C degradation and the denitrification genes, and S genes (especially cys genes) were the main genes linked to the co-occurrence network of the C–N–S-related genes. In summary, this study strengthened our knowledge regarding the C–N–S-related coal microbial communities, which is of great significance in understanding the microbial ecology and geochemical cycle of coals.
The Association of Volunteer Motivation and Thriving at Work of College Students During COVID-19: Job Burnout and Psychological Capital as Mediators

Thriving at work is a type of mental state in which an individual feels vigorous and learning at the same time in the job. Previous studies have shown that individual internal motivation is relevant to thriving at work and volunteer behaviors, but the role of motivation is still to be further explored. Based self-determination theory, this study focuses on the mediating effects of job burnout and psychological capital on the relationship between volunteer motivation and thriving at work. Three hundred forty-nine college student volunteers who participated in psychological assistance volunteer activities during the COVID-19 pandemic were investigated using the Volunteer Function Motivation Inventory, Maslach Burnout Inventory, PsyCap Questionnaire, and Thriving at work scale. The results indicated that job burnout and psychological capital mediate the relationship between volunteer motivation and thriving at work. The results not only offer important theoretical insights of Volunteer Motivation and Thriving at Work, but also generate practical implications regarding how to use motivating Volunteer behavior and enhanced wellbeing at work.
Two‐dimensional frequency decoupling method for curved trajectory synthetic aperture radar imaging

Synthetic aperture radar (SAR) imaging with curved trajectory is difficult due to its severe two-dimensional (2D) space variance. When processing the echo with azimuth-variance, the range cell migration and Doppler modulation of the targets with different azimuth locations are different, which brings a big challenge to image formation. Here, a 2D frequency decoupling method for this case is proposed. Firstly, the range history of the curved trajectory is accurately modelled based on fourth-order Taylor series expansion. Then, the 2D point target reference spectrum of the echo signal is obtained by the method of series reversion. The 2D space variance characteristics of two typical cases with curved trajectory, i.e. geosynchronous SAR and missile-borne SAR, are analysed. Based on the space variance characteristics, a 2D frequency decoupling step is implemented to handle the space-variant phase. Simulations are presented to demonstrate the effectiveness of the proposed algorithm.