Miracle-dz/UniFAR-FTUs huggingface dataset:
Box–Behnken Design of Experiments of Polycaprolactone Nanoparticles Loaded with Irinotecan Hydrochloride

Background: The Box–Behnken design of experiments (BBD) is a statistical modelling technique that allows the determination of the significant factors in developing nanoparticles (NPs) using a limited number of runs. It also allows the prediction of the best levels of variables to obtain the desired characteristics (size, charge, and encapsulation efficiency) of the NPs. The aim of this study was to examine the effect of the independent variables (amount of polymer and drug, and surfactant concentration) and their interaction on the characteristics of the irinotecan hydrochloride (IRH)-loaded polycaprolactone (PCL) NPs and to determine the most optimum conditions for producing the desired NPs. Methods: The development of the NPs was carried out by a double emulsion solvent evaporation technique with yield enhancement. The NPs data were fitted in Minitab software to obtain the best fit model. Results: By using BBD, the most optimum conditions for producing the smallest size, highest magnitude of charge, and highest EE% of PCL NPs were predicted to be achieved by using 61.02 mg PCL, 9 mg IRH, and 4.82% PVA, which would yield 203.01 nm, −15.81 mV, and 82.35% EE. Conclusion: The analysis by BBD highlighted that the model was a good fit to the data, confirming the suitability of the design of the experiments.
Energy operator demodulating of optimal resonance components for the compound faults diagnosis of gearboxes

Compound faults diagnosis is a challenge for rotating machinery fault diagnosis. The vibration signals measured from gearboxes are usually complex, non-stationary, and nonlinear. When compound faults occur in a gearbox, weak fault characteristic signals are always submerged by the strong ones. Therefore, it is difficult to detect a weak fault by using the demodulating analysis of vibration signals of gearboxes directly. The key to compound faults diagnosis of gearboxes is to separate different fault characteristic signals from the collected vibration signals. Aiming at that problem, a new method for the compound faults diagnosis of gearboxes is proposed based on the energy operator demodulating of optimal resonance components. In this method, the genetic algorithm is first used to obtain the optimal decomposition parameters. Then the compound faults vibration signals of a gearbox are subject to resonance-based signal sparse decomposition (RSSD) to separate the fault characteristic signals of the gear and the bearing by using the optimal decomposition parameters. Finally, the separated fault characteristic signals are analyzed by energy operator demodulating, and each one’s instantaneous amplitude can be calculated. According to the spectra of instantaneous amplitudes of fault characteristic signals, the faults of the gear and the bearing can be diagnosed, respectively. The performance of the proposed method is validated by using the simulation data and the experiment vibration signals from a gearbox with compound faults.
Modularity and Vacua in N=1* Supersymmetric Gauge Theory

We investigate the vacuum structure of a massive deformation of the maximally supersymmetric Yang-Mills gauge theory in four dimensions. When the topology of spacetime is trivial, the Witten index can be computed exactly for any gauge group using the theory of nilpotent orbits in Lie algebras. We provide generating functions for classical algebras and an explicit calculation for the exceptional ones. Upon compactification on a circle, one can use a bridge between supersymmetric gauge theories and complex integrable systems to reduce the analysis of vacua to the search of extrema of the twisted elliptic Calogero-Moser Hamiltonian. A careful inspection of global properties of the gauge group and line operators are needed to reach total agreement. Using a combination of numerical exploration on a computer and analytical control through the theory of modular forms, we determine the structure of massive vacua for low-rank gauge algebras and exhibit new modular properties. We also show that massless branches of vacua can exist, and provide an analytic description for rank two gauge algebras.
Informed Consent of 16- to 18-Year-Old Participants in Evaluations

Abstract: Ethics policies require parental consent for “children” less than 18 years old. This article examines whether parental consent should be required for youth aged 16 to 18 years. It examines the current position of youth vis-à-vis services, informed-consent requirements, the quality of parental consent, and youths’ legal and developmental capacity to consent. It concludes that youth have the capacity to consent. Recommendations are made to revise the parental-consent policy and to address the impacts of stress, emotion, and inexperience on youth’s decision making at all evaluation process.
Petrology and geochemistry of the teloloapan subterrane: a lower cretaceous evolved intra-oceanic island-arc

Al sur del Eje Volcánico Mexicano, el subterreno Teloloapan constituye una de las secuencias tectonoestratigráficas incluidas en el subterreno Guerrero. Este subterreno incluye una unidad basal esencialmente volcánica de edad Hauteriviano-Aptiano (formación villa Ayala), compuesta en su mayoria por basaltos y localmente por andesitas y riolitas. Esta unidad es sobreyacida por una unidad de volcaniclásticos de edad Aptiano superior (formación Acapetlahuaya), una unidad de calizas arrecifales (formación Teloloapan)y calizas detríticas finas (formación Amatepec)del Albiano-Cenomaniano inferior y finalmente por una unidad de lutitas y areniscas (formación Pachivia/Miahuatepec)de edad post-Cenomaniano inferior. Las rocas volcánicas muestran características petrográficas, minearlógicas, geoquímicas e isotópicas típicas de las series calco-alcalinas: (i)presencia de basaltos y andesitas de dos piroxenos y anfíbolo; (ii)cristalización temprana de los óxidos de Fe-Ti; (iii)composición de los clinopiroxenos; (iv)comportamiento del Fe durante la diferenciación; (v)concentraciones elevadas en HFSE y en LREE; (vi)relaciones (La/Yb)N elevadas; y, (vii)valores de E(Nd)bajos. Las características petrológicas, geoquímicas e isotópicas son compatibles con un origen en un arco de islas intra oceánico. Comparadas con las rocas calco-alcalinas intra-oceánicas primitivas, las rocas de Teloloapan están enriquecidas en HFSE (Y, Nb, Zr y en menor grado TiO2)y en HREE. Estas carcterísticas son comparables con las observadas en las series calco-alcalinas medianamente ricas y ricas en K de arcos intra-oceánicos maduros como las series calco-alcalinas de los arcos de Sunda o Antillas Menores. Se sugiere que las lavas de Teloloapan feflejan diversos procesos magmáticos como la fusión parcial de una fuente mantélica ligeramente enriquecida modificada por sedimentos pelágicos subdudctados y posteriormente por cristalización fraccionada y/o acumulación cristalinadoi: sin doi
The Association between Perceived Teacher Support, Students’ ICT Self-Efficacy, and Online English Academic Engagement in the Blended Learning Context

The present study intended to examine the relationship between perceived teacher support, students’ ICT self-efficacy, and online English academic engagement in the blended learning setting, especially in mobile-assisted foreign language instruction contexts. A sample of 960 Chinese undergraduate and postgraduate students was recruited to participate in the online questionnaire. SPSS version 24.0 was used for descriptive, correlation, independent samples t-test, and mediation analysis of the three variables. The results showed that: (1) there is a significant correlation between perceived teacher support, students’ ICT self-efficacy, and online English academic engagement; (2) students’ ICT self-efficacy partially mediates the relationship between perceived teacher support and student online English academic engagement; (3) students’ ICT self-efficacies differed by sex and level of education, but not by major; (4) students’ sense of self-competence in ICT self-efficacy has a significant positive influence on engagement with online English learning. The findings reveal that students’ ICT self-efficacy positively impacts students’ online English learning, and perceived teacher support also affects students’ learning engagement. School administrators should encourage teachers to focus on students’ online self-efficacy, especially the sense of environmental control. Implications and further directions for future research are presented at the end.
Construction and Validation of a Model for Predicting Impaired Fasting Glucose Based on More Than 4000 General Population

Purpose Impaired fasting glucose (IFG) is associated with an increased risk of multiple diseases. Therefore, the early identification and intervention of IFG are particularly significant. Our study aims to construct and validate a clinical and laboratory-based nomogram (CLN) model for predicting IFG risk. Patients and Methods This cross-sectional study collected information on health check-up subjects. Risk predictors were screened mainly by the LASSO regression analysis and were applied to construct the CLN model. Furthermore, we showed examples of applications. Then, the accuracy of the CLN model was evaluated by the receiver operating characteristic (ROC) curve, the area under the ROC curve (AUC) values, and the calibration curve of the CLN model in the training set and validation set, respectively. The decision curve analysis (DCA) was used to estimate the level of clinical benefit. Furthermore, the performance of the CLN model was evaluated in the independent validation dataset. Results In the model development dataset, 2340 subjects were randomly assigned to the training set (N = 1638) and validation set (N = 702). Six predictors significantly associated with IFG were screened and used in the construction of the CLN model, a subject was randomly selected, and the risk of developing IFG was predicted to be 83.6% by using the CLN model. The AUC values of the CLN model were 0.783 in the training set and 0.789 in the validation set. The calibration curve demonstrated good concordance. DCA showed that the CLN model has good clinical application. We further performed independent validation (N = 1875), showed an AUC of 0.801, with the good agreement and clinical diagnostic value. Conclusion We developed and validated the CLN model that could predict the risk of IFG in the general population. It not only facilitates the diagnosis and treatment of IFG but also helps to reduce the medical and economic burdens of IFG-related diseases.
Intermittent Voluntary Isometric Contractions Effects on Performance Enhancement and Sticking Region Kinematics in the Bench Press

During the last years, post-activation performance enhancement (PAPE) has gained notorious popularity due to the capacity to improve the acute rate of force development (RFD) using different strategies with different muscle contraction regimes as conditioning stimuli. The aim of the present study was to analyse the role of a maximal isometric post-activation performance enhancement (PAPE) protocol in performance and its effects on the kinematics of the sticking region. Twenty-one trained participants (age 26.4 ± 5.4 years) underwent two experimental sessions: an experimental session consisting of a single set and a single repetition of the bench press at the 93% of 1RM (which is considered a traditional conditioning activity to induce PAPE) (TRAD) and an isometric experimental session (ISO) consisting of 15 maximal voluntary isometric contractions in the sticking region of the medium grip bench press lasting 1 s with a 1 s rest interval between contractions. Both TRAD and ISO experimental conditions improved performance from post0 to post4, post8, post12 and post16, but only the ISO condition improved performance from the start of the lift to the start of the sticking region from pre to post (p < 0.001), and only the ISO condition improved maximum (p = 0.005) and minimum (p = 0.025) peak velocities. The results of this study suggest that short duration maximal voluntary isometric contractions improve the velocity of the lift prior to the initiation of the sticking region, which ultimately improves the impulse and facilitates the lift.
The Limitations of Anterior Knee Displacement during Different Barbell Squat Techniques: A Comprehensive Review

Based on seminal research from the 1970s and 1980s, the myth that the knees should only move as far anterior during the barbell squat until they vertically align with the tips of the feet in the sagittal plane still exists today. However, the role of both the hip joint and the lumbar spine, which are exposed to high peak torques during this deliberate restriction in range of motion, has remained largely unnoticed in the traditional literature. More recent anthropometric and biomechanical studies have found disparate results regarding anterior knee displacement during barbell squatting. For a large number of athletes, it may be favorable or even necessary to allow a certain degree of anterior knee displacement in order to achieve optimal training outcomes and minimize the biomechanical stress imparted on the lumbar spine and hip. Overall, restricting this natural movement is likely not an effective strategy for healthy trained individuals. With the exception of knee rehabilitation patients, the contemporary literature suggests it should not be practiced on a general basis.
Autologous i‐PRF promotes healing of radiation‐induced skin injury

Skin, as an exposed tissue, often suffers damage after exposure to radiotherapy and accidental events, which may lead to the formation of chronic refractory wounds. However, effective treatment options are usually limited for severe radiation‐induced skin injury (RSI). Platelet‐rich plasma (PRP) has been identified to promote wound healing, but whether a new generation of blood‐derived biomaterial, injectable platelet‐rich fibrin (i‐PRF), is effective in repairing RSI remains unclear. In this study, blood was drawn from humans and Sprague–Dawley rats to prepare PRP and i‐PRF, and the regenerative functions of PRP and i‐PRF were investigated by exposing the dorsal skin of SD rats to local radiation (45 Gy) and exposing HDF‐α cells and human umbilical vein endothelial cells (HUVECs) cells to X‐rays (10 Gy). The healing effect of i‐PRF on RSI was analysed by tube formation assay, cell migration and apoptosis assays, ROS assay, wound healing assay, histological characterisation and immunostaining. The results showed that exposure to high doses of radiation reduced cell viability, increased ROS levels and induced cell apoptosis, thereby causing dorsal trauma of rats. However, both PRP and i‐PRF could resisted RSI, and they were capable of reducing inflammation and promoting angiogenesis and vascular regeneration. i‐PRF has a higher concentration of platelets and platelet‐derived growth factors, which has a more convenient preparation method and better repair effect and possesses a good application prospect for the repair of RSI.
Experiences of Women Diagnosed with Borderline Personality Disorder: Perception of Motherhood, Social, Health, and Construction of Gender

Purpose. To explore the experiences of women diagnosed with borderline personality disorder (BPD) from a holistic perspective, incorporating their experiences in the social and health fields and their perception of motherhood, and to analyse the influence of the social construction of gender. Design and Methods. Qualitative study with a hermeneutic phenomenological design. Eight women with a diagnosis of borderline personality disorder participated in the in-depth interviews. Findings. The trauma, stigma, and difficulty associated with motherhood and being a woman are determinants in the experience of symptoms and the recovery from them. Practical Implications. The findings offer keys to improving the quality of women’s nursing care and the treatment they are provided according to gender factors.
Continuous medial models in two-sample statistics of shape

In questions of statistical shape analysis, the foremost is how such shapes should be represented. The number of parameters required for a given accuracy and the types of deformation they can express directly influence the quality and type of statistical inferences one can make. One example is a medial model, which represents a solid object using a skeleton of a lower dimension and naturally expresses intuitive changes such as "bending", "twisting", and "thickening". In this dissertation I develop a new three-dimensional medial model that allows continuous interpolation of the medial surface and provides a map back and forth between the boundary and its medial axis. It is the first such model to support branching, allowing the representation of a much wider class of objects than previously possible using continuous medial methods. A measure defined on the medial surface then allows one to write integrals over the boundary and the object interior in medial coordinates, enabling the expression of important object properties in an object-relative coordinate system. I show how these properties can be used to optimize correspondence during model construction. This improved correspondence reduces variability due to how the model is parameterized which could potentially mask a true shape change effect. Finally, I develop a method for performing global and local hypothesis testing between two groups of shapes. This method is capable of handling the nonlinear spaces the shapes live in and is well defined even in the high-dimension, low-sample size case. It naturally reduces to several well-known statistical tests in the linear and univariate cases.
RNA-seq and Single-Cell Transcriptome Analyses of TRAIL Receptors Gene Expression in Human Osteosarcoma Cells and Tissues

Osteosarcoma (OS) is the most common primary cancer in the skeletal system, characterized by a high incidence of lung metastasis, local recurrence and death. Systemic treatment of this aggressive cancer has not improved significantly since the introduction of chemotherapy regimens, underscoring a critical need for new treatment strategies. TRAIL receptors have long been proposed to be therapeutic targets for cancer treatment, but their role in osteosarcoma remains unclear. In this study, we investigated the expression profile of four TRAIL receptors in human OS cells using total RNA-seq and single-cell RNA-seq (scRNA-seq). The results revealed that TNFRSF10B and TNFRSF10D but not TNFRSF10A and TNFRSF10C are differentially expressed in human OS cells as compared to normal cells. At the single cell level by scRNA-seq analyses, TNFRSF10B, TNFRSF10D, TNFRSF10A and TNFRSF10C are most abundantly expressed in endothelial cells of OS tissues among nine distinct cell clusters. Notably, in osteoblastic OS cells, TNFRSF10B is most abundantly expressed, followed by TNFRSF10D, TNFRSF10A and TNFRSF10C. Similarly, in an OS cell line U2-OS using RNA-seq, TNFRSF10B is most abundantly expressed, followed by TNFRSF10D, TNFRSF10A and TNFRSF10C. According to the TARGET online database, poor patient outcomes were associated with low expression of TNFRSF10C. These results could provide a new perspective to design novel therapeutic targets of TRAIL receptors for the diagnosis, prognosis and treatment of OS and other cancers.
Does Searle’s challenge affect chances for approximating assertion and quotative modal wollen ?

The possibility of reporting on overheard monologic or ‘secret’ language use by means of the German quotative modal wollen shows that a ‘volitional-epistemic’ analysis of the latter is problematic. This finding allows making a further distinction between Searle’s and Zaefferer’s analyses of assertion, indicating that only the former, based solely on speaker commitment, would be able to properly approximate assertion and quotative wollen . However, embeddability of wollen under negation casts doubt on the desirability of such an approximation. Keywords: assertion; commitment; embedding; quotative evidentials; volition
Observation of nanoscale 180° stripe domains in ferroelectric PbTiO3 thin films

We report the observation of periodic 180 degrees stripe domains below the ferroelectric transition in thin films. Epitaxial PbTiO3 films of thickness d=1.6 to 42 nm on SrTiO3 substrates were studied using x-ray scattering. Upon cooling below T(C), satellites appeared around Bragg peaks indicating the presence of 180 degrees stripe domains of period Lambda=3.7 to 24 nm. The dependence of Lambda on d agrees well with theory including epitaxial strain effects, while the suppression of T(C) for thinner films is significantly larger than that expected solely from stripe domains.
Blood Platelets in Infection: The Multiple Roles of the Platelet Signalling Machinery

Platelets are classically recognized for their important role in hemostasis and thrombosis but they are also involved in many other physiological and pathophysiological processes, including infection. Platelets are among the first cells recruited to sites of inflammation and infection and they exert their antimicrobial response actively cooperating with the immune system. This review aims to summarize the current knowledge on platelet receptor interaction with different types of pathogens and the consequent modulations of innate and adaptive immune responses.
Uniformly Most Powerful Unit Root Tests for PANIC

This paper considers panels with cross-sectional dependence generated by dynamic common factors as introduced by Bai and Ng (2004, 2010) and known as the PANIC framework. Using limit experiment theory, we derive the (asymptotic) power envelope for testing for unit roots in the PANIC framework. We obtain the local asymptotic power functions of two of the most popular "second generation" panel unit root tests: those proposed in Moon and Perron (2004) and Bai and Ng (2004, 2010). We show that: i) these tests are asymptotically equivalent, and ii) only attain the power envelope in case the long-run variances of the idiosyncratic components in the PANIC framework are homogeneous. Moreover, we propose a new test that is asymptotically UMP, i.e. whose power function attains the envelope irrespective of possible heterogeneity in the long-run variances. A Monte Carlo study demonstrates that our asymptotic results provide excellent approximations to finite-sample distributions.
Axicabtagene Ciloleucel in the Management of Follicular Lymphoma: Current Perspectives on Clinical Utility, Patient Selection and Reported Outcomes

Abstract Axicabtagene ciloleucel (axi-cel) is an autologous anti-CD19 chimeric antigen receptor T-cell therapy (CAR-T) that has shown efficacy in B-cell non-Hodgkin’s lymphoma. It has shown high efficacy in relapsed/refractory follicular lymphoma (FL) even in the presence of high risk features (early relapse, heavily pretreated patients and bulky disease). Treatment options for R/R follicular lymphoma do not offer long-term remissions, especially in the third-line setting. Axi-cel was studied in R/R FL in the ZUMA-5 study, which showed high response rates with durable remissions. Axi-cel was associated with anticipated but manageable toxicities. Long-term follow up may be able to inform the potential for cure of FL. Axi-cel should be part of the standard of care options for R/R FL beyond second line.