Miracle-dz/UniFAR-FTUs huggingface dataset:
A Veriﬁcation Based Flow Space Management Scheme for Multi-Tenant Virtualized Network

—Cloud services that virtualize existing IT infrastructures at data centers are widely used by governments, universities, and companies. Multi-tenancy is required for data centers to provide a large number of isolated networks to each organization. OpenFlow is a core technology of software deﬁned networking (SDN) and is useful for centrally managing and controlling these networks; however, SDN is used only at the management level. It is desirable to make the ﬂexible features of SDN/OpenFlow available to users ’ virtual networks. FlowVisor [3] virtualizes multi-tenant OpenFlow networks by coordinating multiple controllers, but it is unable to deal with conﬂicts of control rules among individual virtual networks. Administrators of each tenant thus need to design the control rules of their networks carefully. This paper describes a veriﬁcation-based scheme for coordinating multiple tenants ’ OpenFlow networks. The scheme enables administrators to design each tenant network without having to worry about conﬂicts with other tenants. It ensures isolation of virtual networks among multiple tenants transparently. It manages the address space overlaps and resolves conﬂicts in the ﬂow entries.
The 1918 Spanish Influenza Pandemic

1918 H1N1 Spanish influenza pandemic virus (1918PV) killed 4 million people. The first wave of the 1918 H1N1 Spanish influenza pandemic had a mortality comparable to the usual seasonal influenza with a U-shaped mortality-age distribution that involved the very young and elderly. However, the second wave of the 1918 H1N1 Spanish influenza pandemic had a dramatic surge in mortality and a W-shaped mortality-age distribution that involved young adults with a distinct peak of death in individuals between 20 and 40 years of age (Figure a and b) [1]. Analysis of individual gene segment of the 1918PV isolated from archived samples of the 1918 H1N1 Spanish influenza pandemic’s second wave showed that the non-structural gene segment (NS) contributed to the virulence of 1918PV due to its ability to induce cytokine dysregulation and inhibit human inducible pretranscriptional interferon-beta (IFN-β) production [2] and posttranscriptional maturation and nuclear export of host interferonrelated mRNAs [3]. The NS of the 1918PV entered the swine population in 1918 and re-emerged in the 2009 novel H1N1 pandemic virus (2009PV). The 2009PV is able to induce cytokine dysregulation and produced an enhanced mortality with a W-shaped mortality-age distribution that involved the young population. Adaptation in pigs has abolished the ability of the NS of 2009PV to block interferon production at the post-transcriptional level and may account for reduced mortality of 2009PV infection compared with the original 1918PV [3].
Cardiac Magnetic Resonance for Risk Stratiﬁcation of Patients With Frequent Premature Ventricular Contractions

1. Park DW, Kim YH, Yun SC, et al. Comparison of zotarolimus-eluting stents with sirolimusand paclitaxel-eluting stents for coronary revascularization: the ZEST (Comparison of the Efficacy and Safety of Zotarolimus-Eluting Stent with Sirolimus-Eluting and PacliTaxelEluting Stent for Coronary Lesions) randomized trial. J Am Coll Cardiol 2010;56:1187–95. 2. Shin DI, Seung KB, Kim PJ, et al. Long-term coronary endothelial function after zotarolimus-eluting stent implantation. A 9 month comparison between zotarolimus-eluting and sirolimus-eluting stents. Int Heart J 2008;49:639–52. 3. Hamilos M, Sarma J, Ostojic M, et al. Interference of drug-eluting stents with endothelium-dependent coronary vasomotion: evidence for device-specific responses. Circ Cardiovasc Interv 2008;1:193–200. 4. Kim JW, Seo HS, Park JH, et al. A prospective, randomized, 6-month comparison of the coronary vasomotor response associated with a zotarolimusversus a sirolimus-eluting stent: differential recovery of coronary endothelial dysfunction. J Am Coll Cardiol 2009;53:1653–9. 5. Togni M, Raber L, Cocchia R, et al. Local vascular dysfunction after coronary paclitaxel-eluting stent implantation. Int J Cardiol 2007;120: 212–20. 6. Shin DI, Kim PJ, Seung KB, et al. Drug-eluting stent implantation could be associated with long-term coronary endothelial dysfunction. Int Heart J 2007;48:553–67. 7. Kim JW, Suh SY, Choi CU, et al. Six-month comparison of coronary endothelial dysfunction associated with sirolimus-eluting stent versus Paclitaxel-eluting stent. J Am Coll Cardiol Intv 2008;1:65–71.
An Adaptive Multi-agent System for Ambient Assisted Living

—The work presented in this paper is focused on the design and the implementation of an adaptive framework for ambient assisted living applications. The challenge is to provide an approach able to deal with a dynamic environment in order to provide an adequate service to the person. The evolution of the intrusion level of the system based on the degree of urgency and the availability of different communication devices that constitute the environment are particularly targeted. The results obtained with the coalition-based multi-agents system are promising and reﬂects these constraints.
The development and measurement of different service quality models

This article outlines the development of service quality models, from the earlier Nordic model, the Gaps model, SERVQUAL and SERVPERF models, to the most recent, the service quality of internet search engines (adapted from SERVQUAL), and perceptions of educational service quality (adapted from SERVPERF). The author presents and discusses the basis of development of each service model, service quality structures, and element of each service industry. Finally, the implications for service quality model improvement and further research are discussed.
ANALYSIS OF MATERNAL SERUM URIC ACID LEVELS AT DELIVERY AMONG GESTATIONAL HYPERTENSIVE WOMEN

: Introduction: Hypertensive disorders complicating pregnancy are the most common and serious medical disorder and constitute up to 2–10% of all pregnancies. Pregnancy induced hypertension, preeclampsia (PE), and eclampsia are a part of a spectrum of hypertensive disorders that complicate pregnancy as specified by the National High Blood Pressure Education Program (NHBPEP) working group. Aims and objectives: The basic aim of the study is to analyze the maternal serum uric acid levels at delivery among gestational hypertensive women and its effect on fetal growth. Material and methods: This cross sectional study was conducted in Allied Hospital Faisalabad during January 2019 to July 2019. The data was collected from 100 pregnant female patients with gestational age above 32 weeks. The selected participants were divided into 2 groups, one with GH and second group with NP. All the participants were age matched. GH is defined as denovo hypertension with systolic blood pressure (SBP) ≥140 mmHg and diastolic blood pressure (DBP) ≥90 mmHg after 20 weeks of gestation. PE is GH with proteinuria 1+ on dipstick or ≥300 mg/day or Pr:Cr ratio as ≥3.0 mg/g. Results: The data was(5) collected from 100 randomly selected participants. The mean age for NP were 23.2 ± 2.9 and for GH 22.9 ± 3.0. The mean age and gestational age among both groups were
Screening of phosphate solubilizing bacterial isolates for improving growth of wheat

With the aim to select beneficial bacteria exhibiting several plant growth promoting (PGP) traits and develop biofertilizers, the present study was conducted to characterize the native phosphate solubilizing bacteria (PSB) present in wheat rhizosphere in the Northwestern Morocco. A total of 122 rhizobacteria were isolated from the rhizosphere of two wheat varieties (Salama and Rajae) of which 34% was able to solubilizing tri-calcium phosphate (TCP) on Pikovskaya’s agar. On the basis of solubilization index (SI≥ 1.44), 10 rhizobacteria were selected and tested for hydrogen cyanide (HCN) production, quantitative assay of indole acetic acid (IAA) and siderophores production. Three isolates (Rs15, Rs19 and Rr1) were HCN producers. IAA production reached 31.08 mg/l by the isolate Rs19, whereas siderophores production was shown in Rs20, Rr1 and Rr3 isolates. Amount of solubilized phosphate ranged from 35.13 to 217.59 mg P L -1 . Also, the effect of three isolates, Rs15, Rs19 and Rr1 on growth of wheat plants was investigated under culture chamber conditions. Significant increases were obtained for shoot length and dry weight of plants in presence of Rs15 and Rs19 as compared to the control. Analysis of 16S rDNA sequencing demonstrated that the isolates were closely related to Pantoea allii strain BD 390 (RS15), Stenotrophomonas maltophilia strain IAM 12423 (RS19) and Pseudomonas frederiksbergensis strain DSM 13022 (RR1).
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: Nitrogen (N) availability is increasing in many ecosystems due to anthropogenic disturbance. We used a nucleotide analog technique and sequencing of ribosomal RNA genes to test whether N fertilization altered active fungal communities in two boreal ecosystems. In decaying litter from a recently burned spruce forest, Shannon diversity decreased significantly with N fertilization, and taxonomic richness declined from 44 to 33 operational taxonornic units (OTUs). III soils from a mature spruce forest, richness also declined with N fertilization, from 67 to 52 OTUs. eScholarship provides open access, scholarly publishing services to the University of California and delivers a dynamic research platform to scholars worldwide. Fungal community structure in litter differed significantly with N fertilization, primarily because fungi of the order Ceratobasidiales increased in abundance. We observed similar changes in fungal diversity and community structure with starch addition to litter, suggesting that N fertilization may affect fungal communities by altering plant carbon inputs. These changes could have important consequences for ecosystem processes such as decomposition and nutrient mineralization. (c) 2007 Abstract Nitrogen (N) availability is increasing in many ecosystems due to anthropogenic disturbance. We used a nucleotide analog technique and sequencing of ribosomal RNA genes to test whether N fertilization altered active fungal communities in two boreal ecosystems. In decaying litter from a recently burned spruce forest, Shannon diversity decreased signiﬁcantly with N fertilization, and taxonomic richness declined from 44 to 33 operational taxonomic units (OTUs). In soils from a mature spruce forest, richness also declined with N fertilization, from 67 to 52 OTUs. Fungal community structure in litter differed signiﬁcantly with N fertilization, primarily because fungi of the order Ceratobasidiales increased in abundance. We observed similar changes in fungal diversity and community structure with starch addition to litter, suggesting that N fertilization may affect fungal communities by altering plant carbon inputs. These changes could have important consequences for ecosystem processes such as decomposition and nutrient mineralization.
Whole genome-based public health surveillance of less common STEC serovars and 1 untypable strains identifies four novel O genotypes

Shiga toxin-producing E. coli (STEC) and the subgroup of enterohemorrhagic E. coli cause 28 intestinal infections with symptoms ranging from watery diarrhea to hemolytic uremic 29 syndrome (HUS). A key tool for epidemiological differentiation of STEC is serotyping. The 30 serotype in combination with the main virulence determinants gives an important insight into 31 the virulence potential of a strain. However, a larger fraction of STEC found in human 32 disease, including strains causing HUS, belongs to less frequently detected STEC serovars or 33 their O/H antigens are unknown or even untypable. Recent implementation of whole genome 34 sequence (WGS) analysis in principal allows the deduction of serovar and virulence gene 35 information. Therefore we here compared classical serovar and PCR-based virulence marker 36 detection with WGS-based methods for 232 STEC strains focusing on less frequently detected 37 STEC serovars and non-typable strains. We found that WGS-based extraction showed a very 38 high degree of overlap with the more classical methods. Specifically, concordance was 97% 39 for O antigens (OAGs) and 99% for H antigens (HAGs) of typable strains and > 99% 40 concerning stx1/2 or eaeA for all strains. 98% of non-typable OAGs and 100% of non-typable 41 HAGs were defined by WGS analysis. In addition, the novel methods enabled a more 42 complete analysis of strains causing severe clinical symptoms and the description of four 43 novel STEC OAG loci. In conclusion, WGS is a promising tool for gaining serovar and 44 virulence gene information especially from a public health perspective. 45 46 47 48
Osteoclastogenesison Osteoclast Precursors Increases Interaction of Fas Ligand and Fas Expressed

We incidentally found that osteoclast precursors and mature osteoclasts express Fas ligand (FasL) as well as Fas, which was conﬁrmed by ﬂow cytometry, immunoﬂuorescent staining, and RT-PCR. The aim of this study was to determine the role of FasL in differentiation and cell death of osteoclasts. To study the role of FasL in osteoclastogenesis, neutralizing anti-FasL mAb or rFasL was added during receptor activator of NF- (cid:1) B ligand (RANKL)-induced osteoclastogenesis using bone marrow-derived macrophages. Neutralization of endogenous FasL by anti-FasL mAb decreased osteoclastogenesis, whereas rFasL enhanced osteoclast differentiation in a dose-dependent manner. In addition, rFasL up-regulated the secretion of osteoclastogenic cytokines, such as IL-1 (cid:2) and TNF- (cid:3) , and the activation of NF- (cid:1) B. Functional blocking of IL-1 (cid:2) and TNF- (cid:3) using IL-1 receptor antagonist and soluble TNFR conﬁrmed that those cytokines mediated the effect of FasL on osteoclastogenesis. The osteoclast precursors were relatively resistant to rFasL-induced apoptosis especially before RANKL treatment, resulting in minimal cell loss by rFasL treatment during osteoclastogenesis. Although rFasL increased the cell death of mature osteoclasts, growth factor withdrawal induced much more cell death. However, anti-FasL mAb did not affect the survival of mature osteoclasts, suggesting that the endogenous FasL does not have a role in the apoptosis of osteoclasts. Finally, in contrast to the effect on apoptosis, rFasL-assisted
A Self-E cacy-Enhancing Intervention for Chinese Patients after Total Hip Arthroplasty: Study Protocol for A Randomized Controlled Trial with 6-Month Follow-Up

Bo Deng (  dengbo@sysucc.org.cn ) Sun Yat-Sen University Cancer Prevention and Treatment Center: Sun Yat-sen University Cancer Center Yu mei Chen Foshan Hospital of Traditional Chinese Medicine Mei fen Zhang Sun Yat-sen University School of Nursing https://orcid.org/0000-0001-7931-3285 Ya Meng Sun Yat-sen University School of Nursing Yi heng Zhang Sun Yat-sen University School of Nursing Xing xian Tan Foshan Hosipital of Traditional Chinese Medicine, Department of Orthopedics Xiao hong Zhou Foshan Hosipital of Traditional Chinese Medicine, Department of Orthopedics
by .

The flagellar regulator TviA reduces pyroptosis by Salmonella enterica Abstract To discern virulent from innocuous microbes, the innate immune system 27 senses events associated with bacterial access to immuno-privileged sites such 28 as the host cell cytosol. One such pathway is triggered by cytosolic delivery of 29 flagellin, the major subunit of the flagellum, by bacterial secretion systems. This 30 leads to inflammasome activation and subsequent pro-inflammatory cell death 31 (pyroptosis) of the infected phagocyte. In this study, we demonstrate that the 32 causative agent of typhoid fever, Salmonella enterica serovar Typhi, can partially 33 subvert this critical innate immune recognition event. The transcriptional regulator 34 TviA, which is absent from Salmonella serovars associated with human 35 gastroenteritis, repressed expression of flagellin during infection of human 36 macrophage-like (THP-1) cells. This mechanism allowed S . Typhi to dampen 37 inflammasome activation, leading to reduced interleukin (IL)-1 β secretion and 38 diminished cell death. Likewise, introduction of the tviA gene in the non-typhoidal 39 S. enterica serovar Typhimurium reduced flagellin-induced pyroptosis. These 40 data suggest that gene regulation of virulence factors enables S . Typhi to evade 41 innate immune recognition by concealing a pathogen-induced process from 42 being sensed by the inflammasome. ingestion of the human-restricted pathogen Salmonella enterica serovar Typhi ( S . Typhi) results in typhoid fever, a severe febrile illness due to dissemination of S . Typhi to systemic sites (19, 20). After a median incubation period of two weeks, only a fraction of patients develop intestinal complications, with the infiltrates being dominated by mononuclear cells (21). The absence of an initial inflammatory response in the mucosa suggests that unlike Salmonella serovars associated with gastroenteritis, S . Typhi evades detection by innate PRRs in the gut (19, 20). Interestingly, the genome sequences of S . Typhi and S . Typhimurium are highly syntenic with minor insertions and deletion (22), thus raising the question of which genetic determinants are involved in escaping innate immune detection. Here we investigated whether and by which mechanisms S . Typhi is able to evade activation of the inflammasome in human macrophage-like THP-1 cells. Our results demonstrate that reduced flagellin expression enables S . Typhi to avoid inflammasome activation. Tight regulation of the flagellar operon in S . Typhi is mediated by TviA, a regulatory protein that is absent from Salmonella serovars causing gastroenteritis in humans.
Study on Online Shopping Drives affecting Satisfaction of Users

Internet has reduced distance among people of the world. Anyone can communicate at any time from any place around the world with the usage of Internet. Time and place convenience provided by Internet had led to increase in its usage. Internet is been used by the people for varied purpose. The most common use of internet is, as a mode of communication, for getting information, for sale and purchase of product etc. It is due to Internet, that people can purchase anything from any were around the world. There are number of websites which offer varieties of product to users of the net. Current research paper examines the views of users for online shopping site in India. It also aims to identify relation between satisfaction towards Flipkart and views for the site. For the purpose data analysis is done using measure of central tendency, correlation and regression. Results of the study observe that people do agree that online shopping provide time convenience and save their time and money compare to traditional way of shopping. Users also found it risky when bank details were ask for doing shopping. Although, being positive for online shopping users were found preferring traditional way of buying but agree that online shopping will eventually suppressed traditional way of shopping. It was also observed that variables like time savvy, broad range of good, convenience to shop, economy in price, home delivery, cash on delivery, time of delivery, behaviour of delivery boys affect satisfaction of users of „ Flipkart‟ online shopping site.
MYELOID NEOPLASIA HIF-1 a can act as a tumor suppressor gene in murine acute myeloid leukemia

has been proposed to be influenced by low oxygen tension (hypoxia). This signaling, related to the cellular localization inside the bone marrow niche and/or influenced by extrinsic factors, promotes the stabilization of hypoxia-inducible factors (HIFs). Whether HIF-1 a canbeusedasatherapeutictargetinthetreatmentofmyeloidmalignanciesremains unknown. Wehaveused3differentmurinemodelstoinvestigatetheroleofHIF-1 a inacute myeloid leukemia (AML) initiation/progression and self-renewal of LICs. Unexpectedly, we failed to observe a delay or prevention of disease development from hematopoietic cells lacking Hif-1 a . In contrast, deletion of Hif-1 a resulted in faster development of the disease and an enhanced leukemia phenotype in some of the investigated models. Our results therefore warrant reconsideration of the role of HIF-1 a and, as a consequence, question its generic therapeutic usefulness in AML.
Sources of income differences across Chinese provinces during the reform period: a development accounting exercise

China’s rapid and uneven growth since 1978 has not eliminated but even reinforced the persistent income inequality across provinces. While existing literature focuses mainly on the provincial variation in growth performance using cross-province growth regressions or growth accounting, few efforts has been made to directly study the differences in income levels across provinces. This paper explores the proximate causes of cross-province income differences in the framework of development accounting. Rather than assuming a priori values for output elasticities of capital and labor, we estimate them from an aggregate production function using panel data. The accounting results show that differences in total factor productivity (TFP) and in physical capital intensity are both important sources of cross-province income differences, each accounting for roughly half of the variation of income levels. Differences in human capital accumulation explain only a small amount of income differences across provinces. The results are robust to whether or not the assumption of constant returns to scale is imposed, and are valid in the long run. We do not exclude the possibility that interaction between factor accumulation and TFP plays an important role in determining cross-province income differences.
Diabetic 8.3 TCR Transgenic Mice Is Required for Diabetes in Nonobese Autoimmunity to Both Proinsulin and IGRP

T cells speciﬁc for proinsulin and islet-speciﬁc glucose-6-phosphatase catalytic subunit related protein (IGRP) induce diabetes in nonobese diabetic (NOD) mice. TCR transgenic mice with CD8 (cid:1) T cells speciﬁc for IGRP 206–214 (NOD8.3 mice) develop accel-erated diabetes that requires CD4 (cid:1) T cell help. We previously showed that immune responses against proinsulin are necessary for IGRP 206–214 -speciﬁc CD8 (cid:1) T cells to expand. In this study, we show that diabetes development is dramatically reduced in NOD8.3 mice crossed to NOD mice tolerant to proinsulin (NOD-PI mice). This indicates that immunity to proinsulin is even required in the great majority of NOD8.3 mice that have a pre-existing repertoire of IGRP 206–214 -speciﬁc cells. However, protection from diabetes could be overcome by inducing islet inﬂammation either by a single dose of streptozotocin or anti-CD40 agonist Ab treatment. This suggests that islet inﬂammation can substitute for proinsulin-speciﬁc CD4 (cid:1) T cell help to activate IGRP 206–214 speciﬁc T cells. The Journal of Immunology, 2008, 180: 4458–4464.
Electronic Excitations in YTiO3 using TDDFT and electronic structure using a multiresolution framework

We performed ab initio studies of the electronic excitation spectra of the ferromagnetic, Mott-insulator YTiO3 using density functional theory (DFT) and timedependent density functional theory (TDDFT). In the ground state description, we included a Hubbard U to account for the strong correlations present within the d states on the cation. The excitation spectra was calculated using TDDFT linear response formalism in both the optical limit and the limit of large wavevector transfer. In order to identify the local d -d transitions in the response, we also computed the density response of YTiO3 using a novel technique where the basis included Wannier functions generated for the Ti and Y sites. Also, we describe the first implementation of the all-electron Kohn-Sham density functional equations in a periodic system using multi-wavelets and fast integral equations using MADNESS (multiresolution adaptive numerical environment for scientific simulation; http://code.google.com/p/m-a-d-ne-s-s). This implementation is highlighted by the real space lattice sums involved in the application of the Coulomb and bound state Helmlholtz integral operators.