Miracle-dz/UniFAR-FTUs huggingface dataset:
The mechanical behavior of a dynamically stressed customized skull implant made from different types of biomaterials by Additive Manufacturing technologies

"The main objective of the research consists in the determination of the mechanical behavior of a customized implant that is dynamically stressed, especially the way the implant takes external loadings, as well as its influence on the adjacent areas that are destroyed, in close connection with the shape of the implant (solid or perforated) and the type of biomaterial the implant is made from (metallic or non-metallic). The assessment of such a hypothetic situation has been considered in order to determine which material is adequate to be used for the manufacturing of the implant and to determine also if some shape modifications are required to be realized in such a way that the impact shock will be much better resisted and the effect of the impact will be diminished especially in the vital areas, where the implant is in contact with. Such a complex analysis can be realized since the virtual generation of the medical implant, by conceiving different virtual models within the design stage and by performing complex analysis by the using finite element method as well. Our studies showed that the stress state of the assembly components is strongly influenced by the type of material from which the implant is manufactured, The decrease of the implant stiffness by realizing some perforations leads to an increase of the stress state of the implant simultaneous with a decrease of the stress level that is transmitted to the surrounding structures, the implants made from PMMA material have isolating properties superior as compared to the ones of the metallic material. "
Two- and Three-Dimensional Transient Thermoelastic Analysis by the MLPG Method

The meshless local Petrov-Galerkin (MLPG) method for transient linear thermoelastic analysis is presented. Orthotropic material properties are considered here. In uncoupled thermoelasticity, the temperature field is not influenced by displacements. Therefore, in the first step, the heat conduction equation is solved for the temperature distribution in the domain. The equations of motion are then solved with the inertial term considered. A Heaviside step function as the test functions is applied in the weak-form to derive local integral equations for solving twoand three-dimensional problems. Local integral equations are written on small sub-domains with circular or spherical shapes. They surround nodal points which are distributed over the analyzed domain. The spatial variation of the displacements and temperature are approximated by the moving least-squares (MLS) scheme. After performing the spatial integrations, a system of ordinary differential equations for certain nodal unknowns is obtained. The backward finite difference method is applied for the approximation of the diffusive term in the heat conduction equation. Then, the system of the ordinary differential equations of the second order resulting from the equations of motion is solved by the Houbolt finite-difference scheme as a time stepping method.
Quantitative Proteomic and Phosphoproteomic Profiling of Lung Tissues from Pulmonary Arterial Hypertension Rat Model

Pulmonary arterial hypertension (PAH) is a rare but fatal disease characterized by elevated pulmonary vascular resistance and increased pressure in the distal pulmonary arteries. Systematic analysis of the proteins and pathways involved in the progression of PAH is crucial for understanding the underlying molecular mechanism. In this study, we performed tandem mass tags (TMT)-based relative quantitative proteomic profiling of lung tissues from rats treated with monocrotaline (MCT) for 1, 2, 3 and 4 weeks. A total of 6759 proteins were quantified, among which 2660 proteins exhibited significant changes (p-value < 0.05, fold change < 0.83 or >1.2). Notably, these changes included several known PAH-related proteins, such as Retnla (resistin-like alpha) and arginase-1. Furthermore, the expression of potential PAH-related proteins, including Aurora kinase B and Cyclin-A2, was verified via Western blot analysis. In addition, we performed quantitative phosphoproteomic analysis on the lungs from MCT-induced PAH rats and identified 1412 upregulated phosphopeptides and 390 downregulated phosphopeptides. Pathway enrichment analysis revealed significant involvement of pathways such as complement and coagulation cascades and the signaling pathway of vascular smooth muscle contraction. Overall, this comprehensive analysis of proteins and phosphoproteins involved in the development and progression of PAH in lung tissues provides valuable insights for the development of potential diagnostic and treatment targets for PAH.
Reproduction of Sheep through Nuclear Transfer of Somatic Cells: A Bibliometric Approach

Simple Summary Different reproductive biotechnologies have been applied to sheep, such as cloning, which has been successfully applied in this species. In this context, the aim of the present study was to carry out a bibliometric analysis of the scientific literature on cloning applied to sheep reproduction, since the first report was published, to identify the most cited articles, main authors and collaboration among them, published journals, institutions with more published papers, most prolific countries and the network collaboration among them, and research topics. This study collected bibliographic data from 124 papers relating to cloning of sheep. The articles that were cited more often addressed topics related to the generation of transgenic animals, recovery of wild species, and xenotransplants. So far, no bibliometric studies have been conducted about cloning of sheep. Abstract Somatic cell nuclear transfer (SCNT) is a reproductive biotechnology with great potential in the reproduction of different species of zootechnical interest, including sheep. This study aimed to carry out a bibliometric analysis of scientific papers published on the application of SCNT in sheep reproduction during the period 1997–2023. The search involved the Science Citation Index Expanded and Social Sciences Citation Index databases of the main collection of the Web of Sciences with different descriptors. A total of 124 scientific papers were analyzed for different bibliometric indicators using the VOSviewer software. Since 2001, the number of SCNT-related papers that have been published concerning sheep reproduction has increased and it has fluctuated in ensuing years. The main authors, research groups, institutions, countries, papers, and journals with the highest number of papers related to the application of SCNT in sheep reproduction were identified, as well as the topics that address the research papers according to the terms: somatic cell, embryo, oocyte, gene expression, SCNT, and sheep.
Strengthening Equitable Access to Care and Support for Children with Cerebral Palsy and Their Caregivers

Cerebral palsy is one of the most prevalent groups of motor disorders affecting children and adults across the world. As increasingly more children with cerebral palsy are living longer into adulthood, it is ever more crucial to ensure access to timely and needed early intervention from the onset of diagnosis, on a continuum, to optimize medical, developmental, socio-emotional, and academic outcomes for these children over time. The American Academy of Pediatrics (AAP), in collaboration with the American Academy of Cerebral Palsy and Developmental Medicine (AACPDM), substantially revised the clinical practice guidelines for cerebral palsy in 2022, after their prior publication of the guidelines in 2006. The revised guidelines account for a range of considerations that are in line with the biopsychosocial, risk and resilience, and family-centered care models as well as promote a more strengths-based approach to care. Furthermore, there is increased emphasis in the guidelines on promoting equitable access to care as part of contributing towards health equity for all children with cerebral palsy. In addition, the 2022 guidelines clearly present recommendations for earlier diagnosis of cerebral palsy, potentially as early as infancy, as the basis for activating access to early intervention services for children that can bolster their neuroplasticity and global development from an earlier age onward. We consolidate the existing literature on caregiver perceptions, beliefs and concerns surrounding earlier diagnosis of cerebral palsy and connect them to the recommendations in the revised guidelines. We also delineate several considerations surrounding education for healthcare providers and caregivers of children in navigating the chronicity of cerebral palsy in both community and healthcare contexts. There is a scant amount of literature on cerebral palsy across traditional and nontraditional sources of media in published studies, which we also review. Lastly, we present a wealth of recommendations for further research and practice that account for the revised 2022 guidelines, caregiver preferences and acceptability of care, and health equity as the bases for strengthening equitable access to care for children with cerebral palsy on a continuum as they transition into adulthood.
Spatiotemporal Variability in Total Dissolved Solids and Total Suspended Solids along the Colorado River

The Colorado River is a principal source of water for 40 million people and farmlands in seven states in the western US and the Republic of Mexico. The river has been under intense pressure from the effects of climate change and anthropogenic activities associated with population growth leading to elevated total dissolved solid (TDS) and total suspended solid (TSS) concentrations. Elevated TDS- and TSS-related issues in the basin have a direct negative impact on the water usage and the ecological health of aquatic organisms. This study, therefore, analyzed the spatiotemporal variability in the TDS and TSS concentrations along the river. Results from our analysis show that TDS concentration was significantly higher in the Upper Colorado River Basin while the Lower Colorado River Basin shows a generally high level of TSSs. We found that the activities in these two basins are distinctive and may be a factor in these variations. Results from the Kruskal–Wallis significance test show there are statistically significant differences in TDSs and TSSs from month to month, season to season, and year to year. These significant variations are largely due to seasonal rises in consumptive use, agriculture practices, snowmelts runoffs, and evaporate rates exacerbated by increased temperature in the summer months. The findings from this study will aid in understanding the river’s water quality, detecting the sources and hotspots of pollutions to the river, and guiding legislative actions. The knowledge obtained forms a strong basis for management and conservation efforts and consequently helps to reduce the economic damage caused by these water quality parameters including the over USD 300 million associated with TDS damages.
Output Feedback Stabilization for a Discrete-Time

This study employs the free-weighting matrix approach to in- vestigate the output feedback control of a linear discrete-time system with an interval time-varying delay. First, the delay-dependent stability is an- alyzed using a new method of estimating the upper bound on the differ- ence of a Lyapunov function without ignoring any terms; and based on the results, a design criterion for a static output feedback (SOF) controller is derived. Since the conditions thus obtained for the existence of admissible controllers are not expressed strictly in terms of linear matrix inequali- ties, a modified cone complementarity linearization algorithm is employed to solve the nonconvex feasibility SOF control problem. Furthermore, the problem of designing a dynamic output feedback controller is formulated as one of designing an SOF controller. Numerical examples demonstrate the effectiveness of the method and its advantage over existing methods. Index Terms—Discrete-time systems, linear matrix inequality (LMI), output feedback, stabilization, time-varying delay.
Comparative Study on the Indoor Air Quality in Critical Areas of Hospitals in Malaysia

Indoor Air Quality (IAQ) is the air quality within and around buildings and structures, particularly regarding building occupants’ health and comfort. IAQ assessments were performed using an objective measurement of molecular gaseous pollutants to determine the IAQ profile in the hospital’s critical areas. It also analyses the effects on patients in different environments and the sources that result in deviations from approved criteria. This comparative study is aimed to investigate the concentration of different compounds in different critical departments in the hospital and propose solutions to the related problem as an improvement in indoor air quality. The data was compared with the standards and regulations. It was found that the TVOC level in the CCU department, specifically in the fluoroscopy room, has exceeded the allowable limit. A few suggestions have been raised to lower the exceeded value. The risks and symptoms held by the occupants in the hospital buildings if they face poor indoor air quality were discussed. Further study can be conducted to relate the short and long-term health issues among medical staff to poor indoor air quality.
Two-Dimensional Seismic Wave Modeling and Inversion by the Boundary Element Method

Surface wave methods (SWM) are widely used for the geophysical characterization of geological bodies and tectonic structures in both Earth Sciences and Engineering. SWMs exploit the dispersive nature of Rayleigh waves to indirectly estimate shear wave velocity profiles from surface wave measurements, but they are limited to parallel-layered geometries. To overcome such limitations, we exploit the Boundary Element Method (BEM) to define a new class of geometric inversion models that allows to go directly from raw measurements to estimating the shape of laterally varying soil interfaces. The proposed approach enables a robust identification of the subsurface geometry and it aims at filling the gap between the standard simplistic parallel-layered-based SWM and the more complex three-dimensional Full Wave Inversion (FWI) based on Finite Element Methods. Numerical tests on synthetic data unveil the effectiveness of the inverse algorithm and its applicability to wave measurements. An application to field data is finally presented.
Folate and Folic Acid Metabolism: A Significant Nutrient-Gene-Environment Interaction

Folate has an important metabolic role by providing one carbon units that are used for nucleotide biosynthesis and methylation reactions that are both vital for epigenetic control, genomic stability and the maintenance of health. Important not only for its availability as an essential nutrient but folate also intertwines us firmly within the environment as part of an unexpected link between light and the genome. Folate deficiency has been overcome by replacement with folic acid, taken as a supplement and/or through food fortification but is this solving one problem but risking others with the wider long-term implication of this manipulation in its potential to alter the human genome. The mandatory folic acid food fortification public health policy and implementation needs to be re-examined and possibly debated in the public arena, particularly in view of the risk of altering the human genome. Have the public been adequately informed and are there implications for the whole vitamin and mineral supplement industry?
Energy harvesting by flow-induced flutter in a simple model of an inverted piezoelectric flag

Two-dimensional numerical simulations are used to study the coupled fluid–structure–electric interaction of a simple model of an inverted piezoelectric flag, and to investigate the dynamics of the flow–structure interaction of this configuration as well as its energy harvesting performance. In particular, the dynamic response of the inverted flag as well as the associated flow patterns are examined for a range of inertia, bending stiffness and Reynolds numbers, and categorized into distinct vibrational states based on the symmetry of the motion as well as the amplitude. Simulations indicate that large-amplitude vibrations can be achieved over a large range of parameters and there is also evidence of lock-on between the flag flutter and the intrinsic wake shedding phenomenon. The initial inclination of the flag to the prevailing flow is found to significantly affect the flutter performance for inclination angles exceeding $15^{\circ }$ . The state with large symmetric flutter is identified as being most promising for energy harvesting, and the effect of piezoelectric material parameters on the energy harvesting performance of this flutter state is examined in detail. The maximum energy efficiency of the flags is found to be approximately $7\,\%$ , and the maximum occurs when there is a match between the time scales of flutter and the intrinsic time scale of the piezoelectric circuit. The simulations are used to examine a simple scaling law that could be used to predict the energy harvesting performance of such devices.
L’hyperanneau des classes d’adèles

The hyperring of adèle classes. I present here some recent results (obtained in collaboration with C. Consani [3], [4], [5], [6]) about the “characteristic 1 ” limit case. The main goal is to prove that the adèle class space of a global ﬁeld, which, up to now, has only been considered as a noncommutative space, has in fact a natural algebraic structure. We will also see that the construction of the Witt ring in characteristic p > 1 has a characteristic 1 analogue and that the deformation of the additive structure implies, in a crucial manner, the entropy function.
Spatial Ecology of Reddish-Brown Cuxiú Monkeys (Chiropotes sagulatus, Pitheciidae) in an Isolated Forest Remnant: Movement Patterns and Edge Effects

Habitat loss, and subsequent fragmentation, can increase the amount of forest edge. Primate species vary in their responses to such changes in their habitat. We studied the movement ecology of a group of reddish-brown cuxiú monkeys (Chiropotes sagulatus, Pitheciidae) in a small (13 ha), isolated forest remnant that was <3% of the species’ typical home range in the region. Every 5 min we recorded the group’s latitude and longitude, and the behavior of all individuals in sight. We calculated distance, speed, and trajectory of travel routes, and distance from every location to the nearest forest edge. Using Lidar data, we calculated canopy height. Cuxiús traveled in all cardinal directions, but they turned left more often than right, and they traveled at a faster speed to locations where the monkeys fed than where they did not eat. Although cuxiús used forest from the edge to the interior, they concentrated their movements and activities >30 m from the forest edge. Furthermore, their food sites were located less often near the forest edge, and canopy height of food trees near the forest edge was lower than canopy height of food trees at a greater distance from the edge. Although edge effects impacted the monkeys’ movement, trees >15 m at the forest edge can provide resources. Future research can examine ecological variables in more detail with the movement patterns.
Nursing Students’ Evolving Perceptions of Online Learning: A Hierarchy of Curricula

Many nursing programs had relatively light online learning components before the COVID-19 pandemic. The transition to fully online courses without preliminary planning represented a problematic shock to most nursing students and faculty. To understand students’ perceptions of the critical success of online learning factors, an empirical comparison was conducted of nursing (n = 126) and non-nursing students (n = 1766) with similar demographic characteristics, but in different timeframes. A two-sample t-test was conducted for each question to ascertain significant differences in student perceptions between nursing and non-nursing students. While the ranking of critical success factors was similar for nursing and other students, the perceptions of nursing students were generally far more critical of the capability of online learning due, partially due to the perception that the online medium is less well suited to nursing education, and partially to instructional challenges caused by the rapid transition and chaos caused by the pandemic. The pandemic provided an inferior initial exposure to online nursing education in programs that had not previously prepared for online instruction, but had an abnormally increased demand for more online education. Without aggressive efforts to improve online teaching in programs with similar circumstances, students’ perceptions of overall quality may not improve significantly in the long term.
On preparation theorems for Ran, exp-definable functions

In this article we give strong versions for preparation theorems for $\mathbb{R}_{\textnormal{an,exp}}$-definable functions outgoing from methods of Lion and Rolin ($\mathbb{R}_{\textnormal{an,exp}}$ is the o-minimal structure generated by all restricted analytic functions and the global exponential function). By a deep model theoretic fact of Van den Dries, Macintyre and Marker every $\mathbb{R}_{\textnormal{an,exp}}$-definable function is piecewise given by $\mathcal{L}_{\textnormal{an}}(\exp,\log)$-terms where $\mathcal{L}_{\textnormal{an}}(\exp,\log)$ denotes the language of ordered rings augmented by all restricted analytic functions, the global exponential and the global logarithm. So our idea is to consider log-analytic functions at first, i.e. functions which are iterated compositions from either side of globally subanalytic functions and the global logarithm, and then $\mathbb{R}_{\textnormal{an,exp}}$-definable functions as compositions of log-analytic functions and the global exponential.
Novel Expression of GLUT3, GLUT6 and GLUT10 in Equine Gluteal Muscle Following Glycogen-Depleting Exercise: Impact of Dietary Starch and Fat

Horses have a slow rate of muscle glycogen repletion relative to other species for unknown reasons. Our aim was to determine the expression of glucose transporters (GLUT) and genes impacting GLUT4 expression and translocation in the gluteal muscle. Five fit Thoroughbred horses performed glycogen-depleting exercises on high-starch (HS, 2869 g starch/day) and low-starch, high-fat diets (LS-HF, 358 g starch/d) with gluteal muscle biopsies obtained before and after depletion and during repletion. Muscle glycogen declined by ≈30% on both diets with little increase during repletion on LS-HF. Transcriptomic analysis identified differential expression (DE) of only 2/12 genes impacting GLUT4 translocation (two subunits of AMP protein kinase) and only at depletion on LS-HF. Only 1/13 genes encoding proteins that promote GLUT4 transcription had increased DE (PPARGC1A at depletion LS-HF). GLUT4 comprised ≈30% of total GLUT mRNA expression at rest. Remarkably, by 72 h of repletion expression of GLUT3, GLUT6 and GLUT10 increased to ≈25% of total GLUT mRNA. Expression of GLUT6 and GLUT10 lagged from 24 h of repletion on HS to 72 h on LS-HF. Lacking an increase in GLUT4 gene expression in response to glycogen-depleting exercise, equine muscle increases GLUT3, GLUT6 and GLUT10 expression potentially to enhance glucose transport, resembling responses observed in resistance trained GLUT4-null mice.
Numerical solution for the model of RLC circuit via the fractional derivative without singular kernel

The numerical approximation of the Caputo–Fabrizio fractional derivative with fractional order between 1 and 2 is proposed in this work. Using the transition from ordinary derivative to fractional derivative, we modified the RLC circuit model. The Crank–Nicolson numerical scheme was used to solve the modified model. We present the stability analysis of the numerical scheme for solving the modified equation and some numerical simulations for different values of the order of derivation.