Miracle-dz/UniFAR-FTUs huggingface dataset:
JNMR: Joint Non-Linear Motion Regression for Video Frame Interpolation

Video frame interpolation (VFI) aims to generate predictive frames by motion-warping from bidirectional references. Most examples of VFI utilize spatiotemporal semantic information to realize motion estimation and interpolation. However, due to variable acceleration, irregular movement trajectories, and camera movement in real-world cases, they can not be sufficient to deal with non-linear middle frame estimation. In this paper, we present a reformulation of the VFI as a joint non-linear motion regression (JNMR) strategy to model the complicated inter-frame motions. Specifically, the motion trajectory between the target frame and multiple reference frames is regressed by a temporal concatenation of multi-stage quadratic models. Then, a comprehensive joint distribution is constructed to connect all temporal motions. Moreover, to reserve more contextual details for joint regression, the feature learning network is devised to explore clarified feature expressions with dense skip-connection. Later, a coarse-to-fine synthesis enhancement module is utilized to learn visual dynamics at different resolutions with multi-scale textures. The experimental VFI results show the effectiveness and significant improvement of joint motion regression over the state-of-the-art methods. The code is available at https://github.com/ruhig6/JNMR.
Translated points for contactomorphisms of prequantization spaces over monotone symplectic toric manifolds

We prove a version of Sandon's conjecture on the number of translated points of contactomorphisms for the case of prequantization bundles over certain closed monotone symplectic toric manifolds. Namely we show that any contactomorphism of such a prequantization bundle lying in the identity component of the contactomorphism group possesses at least $N$ translated points, where $N$ is the minimal Chern number of the symplectic toric manifold. The proof relies on the theory of generating functions coupled with equivariant cohomology, whereby we adapt Givental's approach to the Arnold conjecture for integral symplectic toric manifolds to the context of prequantization bundles.
Modélisation du risque de défaut en entreprise

Dans une premiere partie, on etudie quelques problemes d'arret optimal de la forme $sup_{\tau\in \Delta, \tau\geq 0} \esp_v\left[g(V_{\tau})\right] \hbox{~ou}~ sup_{\tau\in \Delta, \tau\geq 0} \esp_v\left[e^{-r\tau}\bar{g}(V_{\tau})\right],$ ou $V$ est un processus stochastique, $g$ et $\bar{g}$ deux fonctions boreliennes, $r>0$ et $\Delta$ est l'ensemble des $\F^V$-temps d'arret ($\F_.^V$ etant la filtration engendree par le processus $V$). L'etude de ces problemes est motivee par les applications dans plusieurs domaines comme la finance, l'economie ou la medecine. La premiere partie est une mise en evidence du fait que le plus petit temps d'arret optimal est parfois un temps d'atteinte. C'est pourquoi, dans la deuxieme partie de la these, on s'interesse a la loi d'un temps d'atteinte d'un processus de Levy a sauts ainsi qu'a quelques applications a la finance, plus precisement lors du calcul de l'intensite de ce temps d'arret associee a une certaine filtration $\F$. Deux cas sont presentes : quand le temps d'arret est un $\F$-temps d'arret et quand il ne l'est pas.
Enhancement of Healthcare Data Transmission using the Levenberg-Marquardt Algorithm

In the healthcare system, patients are required to use wearable devices for the remote data collection and real-time monitoring of health data and the status of health conditions. This adoption of wearables results in a significant increase in the volume of data that is collected and transmitted. As the devices are run by small battery power, they can be quickly diminished due to the high processing requirements of the device for data collection and transmission. Given the importance attached to medical data, it is imperative that all transmitted data adhere to strict integrity and availability requirements. Reducing the volume of healthcare data and the frequency of transmission will improve the device battery life via using inference algorithm. There is an issue of improving transmission metrics with accuracy and efficiency, which trade-off each other such as increasing accuracy reduces the efficiency. This paper demonstrates that machine learning can be used to analyze complex health data metrics such as the accuracy and efficiency of data transmission to overcome the trade-off problem using the Levenberg-Marquardt algorithm to enhance both metrics by taking fewer samples to transmit whilst maintaining the accuracy. The algorithm is tested with a standard heart rate dataset to compare the metrics. The result shows that the LMA has best performed with an efficiency of 3.33 times for reduced sample data size and accuracy of 79.17%, which has the similar accuracies in 7 different sampling cases adopted for testing but demonstrates improved efficiency. These proposed methods significantly improved both metrics using machine learning without sacrificing a metric over the other compared to the existing methods with high efficiency.
Effectiveness of the University Web Pages in Marketing Academic Programs and Attracting Students in Dubai

Universities like other organizations are rushing to determine how they can use information technology profitably and understand what and how technologies can enhance their business strategies. The present study investigates into how information technology in the form of active web pages is used as a marketing strategy in attracting potential students, creating more value to customers (potential students/students), differentiation and e-communications. Correspondingly, 14 University WEB pages of Dubai are evaluated on criteria and sub criteria that total up to 45 criteria to understand the effectiveness of e-marketing. The analysis of this study contribute to the fact that University WEB pages are of not similar in nature and have different strategies in corresponding and attracting potential students. The study also highlights the aims of University WEB marketing sophisticated marketing strategies related to positioning and branding can be seen in fewer Universities. The study concludes in drawing a conceptual framework that propagates a system wherein, information technology and the WEB page can be fruitfully utilized in not only attracting potential students and stakeholders but also can be effective in transforming students to University brand ambassadors.
Linear forms in the logarithms of algebraic numbers I - IV Mathematika 13

A magnetic domain storage device comprising a ferromagnetic, polycrystalline metal layer which is applied to a support and comprises areas of different coercivity, the areas of lower coercivity in the form of strip-shaped channels being surrounded by areas of higher coercivity; a system of electrical conductors, extending in planes arranged parallel and in close vicinity to the ferromagnetic layer for creating, propagating and detecting magnetic domains in the channels of lower coercivity; and a baseplate with electrical connections. The areas of lower coercivity follow a path similar to a spiral with its one end adjacent to the center of the support and the other end adjacent to a corner of the support and executing at least one full 360 DEG turn between both ends. The domain storage devices of this type are distinguished by a higher storage capacity.
Acentos prenucleares: evidencia sobre el español

En esta investigación se muestra que los acentos pr enucleares L*+H no son preponderantes en el español; en cambio, es recurre nte la presencia de acentos tonales H* tanto en combinaciones monotonales como bitonales. Se analiza la entonación dentro del modelo autosegmental y métric o (AM), revisado. Se estudian cuatro corpus formales (Colombia, Cuba, Ur uguay y Argentina) y un corpus peninsular. Los datos se someten a un refina mie to psicofonético basado en umbrales perceptivos, que actúa en la int erfaz entre el componente fonético y el componente fonológico con el fin de d eterminar los primitivos fonológicos. El espacio temporal de análisis es la sílaba pretónica (periférica y débil), la sílaba acentuada (central y fuerte) y la síl ba postónica (periférica y débil). El espacio melódico de análisis es una altu ra onal de 1.50 semitono, los tonos son inferiores (no estrellados) o son sup eriores (estrellados) a ese umbral percep-tivo. En la secuencia LH se minimiza el valor fonológico L debido a su recurrencia en el español y en la mayor ía de las lenguas, no es valor de contraste. En la secuencia LH se determina que el valor H es significativo sólo si es superior al umbral percept ivo y tiene una representación mental marcada, estrellada. Los hall azgos son similares a los obtenidos en otras investigaciones sobre el español peninsular e insular y sobre discursos espontáneos y semiespontáneos en es pañol hispanoamericano.
Major Nuclear Accidents - A Review

In Nuclear power plant (NPP) heat source is a nuclear reactor which deliveries enormous scale electrical power at inexpensive amount as a improper load to electrical grids historically even though the nuclear business has good safety record we can speak a bunch about nuclear accidents like Chernobyl accident. This article reviews the reactor safety technology and how Modern nuclear reactors are disposed to accidents, shortages of high quality uranium ore may be imminent and the thermoelectric fuel cycle of nuclear plants consumes and degrades vast quantities of water. Safety of NPP has taken methods to discourse new safety challenges raised from the recent accident. Though, safety has been major alarm due to potential release of radioactive material from an accident.
DMSO_A_321340 3517..3521

Interdisciplinary Department of Medicine, University of Bari “Aldo Moro” Medical School, Bari, 70124, Italy Introduction: New antidiabetic drugs have simplified treatment regimens in patients with type-2 diabetes (T2D). More importantly, they have proven to reduce cardiovascular risk by lowering insulin-resistance, blood pressure and body weight, in addition to avoiding inappropriate insulin therapy, responsible for hypoglycemic episodes and weight gain. In this context, accurate assessment of the metabolic status of T2D patients becomes essential. The C-peptide assay is a simple but often overlooked test that can provide a fundamental contribution to the correct disease classification and optimal therapeutic management of diabetic patients. Clinical Case: We report the case of a 72-year-old patient, treated with insulin for 26 years after a diagnosis of type-1 diabetes (T1D), resulting in inadequate glycemia control and a severe evolution of cardiovascular complications. After an accurate evaluation of the clinical history, phenotype and laboratory data, including the determination of C-peptide serum levels, a diagnosis was made of T2D not T1D. Considering the patient’s very high cardiovascular risk and dysmetabolic profile, insulin therapy was discontinued and more appropriate therapy with dulaglutide and metformin was instituted. These overall therapeutic modifications yielded remarkable clinical advantages in terms of the glycometabolic profile, weight reduction, abdominal circumference and body mass index decrease, as well as a better quality of life, with complete resolution of the dangerous hypoglycemic episodes. Conclusion: In the era of new cardioprotective antidiabetic drugs, we believe the importance of the C-peptide assay should be re-evaluated in order to avoid misdiagnosis and to improve the therapeutic approach to T2D.
in Mixed Allogeneic Chimeras Primary and Secondary Immunocompetence

2 Targeted disruption of T cell costimulatory pathways, particularly CD28 and CD40, has allowed for the development of minimally myeloablative strategies for the induction of mixed allogeneic chimerism and donor-speciﬁc tolerance across full MHC barriers. In this study we analyze in depth the ability of mixed allogeneic chimeras in two strain combinations to mount effective host-restricted and donor-restricted antiviral CD4 and CD8 responses, as well as the impact of development of mixed chimerism on the maintenance of pre-existing memory populations. While antiviral CD8 responses in mixed chimeras following acute viral infection with lymphocytic choriomeningitis virus Armstrong or vaccinia virus are largely host-restricted, donor-restricted CD8 responses as well as host- and donor-restricted CD4 responses are also readily detected, and virus is promptly cleared. We further demonstrate that selection of donor-restricted T cells in mixed chimeras is principally mediated by bone marrow-derived cells in the thymus. Conversely, we ﬁnd that mixed chimeras exhibit a deﬁcit in their ability to deal with a chronic lymphocytic choriomeningitis virus clone 13 infection. Encouragingly, pre-existing memory populations are largely unaffected by the development of high level mixed chimerism and maintain the ability to control viral rechallenge. Our results suggest that while pre-existing T cell memory and primary immunocompetence to acute infection are preserved in mixed allogeneic chimeras, MHC class I and/or class II tissue matching may be required to fully preserve immunocompetence in dealing with chronic viral infections. The Journal of Immunology, 2003, 170: 2382–2389.
CMAR_A_278902 12841..12849

1Department of Gastroenterology, The First People’s Hospital of Lianyungang, Lianyungang, Jiangsu Province, 222000, People’s Republic of China; 2Department of Gastroenterology, First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, People’s Republic of China; 3Department of Functional Examination, Jinan Central Hospital, Jinan, Shandong Province 250014, People’s Republic of China; 4Department of Gastroenterology, Jinan Central Hospital, Jinan, Shandong Province 250014, People’s Republic of China Introduction: Gastric cancer occurred in China and even the whole East Asia with high incidence. The objective of this study was to investigate the role of IL-17 in gastric cancer cells mediated by LCN2 binding to SLPI. Methods: The expression of LCN2 and SPLI in gastric cancer cells and transfection effects were confirmed by RT-qPCR analysis. The proliferation, clone formation ability, invasion, migration, apoptosis, and cell cycle of gastric cancer cells were in turn detected by CCK-8 assay, clone formation assay, transwell assay, wound healing assay, and flow cytometry analysis. The combination between LCN2 and SLPI was determined by co-immunoprecipitation assay. The expression of Caspase-3, Bcl-2, cyclinB1, cyclinD1, MMP9, and SLPI in gastric cancer cells was detected by Western blot analysis. Results: LCN2 and SPLI exhibited the highest levels in AGS cells, and thus AGS cells were selected for the next experiments. Down-regulation of LCN2 suppressed the proliferation and clone formation ability of AGS cells treated with IL-17. IL-17 promoted the invasion and migration of AGS cells, which was partially reversed by the down-regulation of LCN2. Down-regulation of LCN2 mediated by IL-17 promoted apoptosis and suppressed the cell cycle of AGS cells. Discussion: Down-regulation of LCN2 mediated by IL-17 suppressed the proliferation and suppressed the migration and invasion and cell cycle of gastric cancer cells by targeting SLPI.
Chapter 8 Inhibitors of JmjC-containing Histone Demethylases

Histone demethylases (KDMs) catalyse the removal of N-methyl marks on histones and play important roles in epigenetic regulation. Abnormal histone methylation and dysregulation of KDMs have been linked to multiple diseases, and KDMs are emerging as promising therapeutic targets. This Chapter provides an overview of JmjC-domain containing KDMs (JmjC-KDMs), with a particular focus on recent advances in JmjC-KDM inhibitor development from a structural perspective.
A novel approach for 2-degrees of freedom redundant parallel manipulator dynamics

A novel Udwadia–Kalaba approach for redundant parallel manipulator dynamics is presented in this article. This methodology is explicit and simple which is suitable for systems with holonomic or non-holonomic constraints. As parallel manipulator is a closed-loop mechanism, it is complex to build the dynamical model, especially for redundant parallel manipulators. This article is the first to apply Udwadia–Kalaba equation to the dynamics modeling of the redundant actuation system. In this article, we segment the parallel manipulator into several subsystems and cluster them together due to kinematic constraints. Based on Udwadia–Kalaba approach, we can establish both the direct dynamical model and inverse dynamical model of the 2-degrees of freedom redundant parallel manipulator concisely and explicitly. We use MATLAB to carry on the numerical simulation and the analysis, the results show that the approach is feasible and reliable for the 2-degrees of freedom redundant parallel manipulator.
p14 Activates a Tip60-Dependent and p53-Independent ATM/ATR/CHK Pathway in Response to Genotoxic Stress

p14 is a tumor suppressor that controls a well-described p53/Mdm2-dependent checkpoint in response to oncogenic signals. Here, new insights into the tumor-suppressive function of p14 are provided. We previously showed that p14 can induce a p53-independent G2 cell cycle arrest. In this study, we demonstrate that the activation of ATM/ATR/CHK signaling pathways contributes to this G2 checkpoint and highlight the interrelated roles of p14 and the Tip60 protein in the initiation of this DNA damage-signaling cascade. We show that Tip60 is a new direct p14 binding partner and that its expression is upregulated and required for ATM/CHK2 activation in response to p14. Strikingly, both p14 and Tip60 products accumulate following a cell treatment with alkylating agents and are absolutely required for ATM/CHK2 activation in this setting. Moreover, and consistent with p14 being a determinant of CHK2 phosphorylation in lung carcinogenesis, a strong correlation between p14 and phospho-CHK2 (Thr68) protein expression is observed in human lung tumors (P < 0.00006). Overall, these data point to a novel regulatory pathway that mediates the p53-independent negative-cell-growth control of p14. Inactivation of this pathway is likely to contribute to lung carcinogenesis.
Management of Malaria: A Systematic Literature Review

A systematic literature review was conducted to assess the effectiveness of strategies to improve community case management (CCM) of malaria. Forty-three studies were included; most (38) reported indicators of community health worker (CHW) performance, 14 reported on malaria CCM integrated with other child health interventions, 16 reported on health system capacity, and 13 reported on referral. The CHWs are able to provide good quality malaria care, including performing procedures such as rapid diagnostic tests. Appropriate training, clear guidelines, and regular supportive supervision are important facilitating factors. Crucial to sustainable success of CHW programs is strengthening health system capacity to support commodity supply, supervision, and appropriate treatment of referred cases. The little evidence available on referral from community to health facility level suggests that this is an area that needs priority attention. The studies of integrated CCM suggest that additional tasks do not reduce the quality of malaria CCM provided sufficient training and supervision is maintained.
Upwind discretisation of a time-dependent two dimensional grade-two fluid model

In this paper, we propose a finite-element scheme for solving numerically the equations of a transient two dimensional grade-two fluid non-Newtonian Rivlin-Ericksen fluid model. This system of equations is considered an appropriate model for the motion of a water solution of polymers. As expected, the difficulties of this problem arise from the transport equation. As one of our aims is to derive unconditional a priori estimates from the discrete analogue of the transport equation, we stabilize our scheme by adding a consistent stabilizing term. We use the IP2 − IP1 Taylor-Hood finite-element scheme for the velocity v and the pressure p, and the discontinuous IP1 finite element for an auxiliary variable z. The error is of the order of h + k, considering that the discretization of the transport equation loses inevitably a factor h.
Récepteurs SIMO MLSE Widely Linear

This paper derives the maximum likelihood sequence estimation (MLSE) single input multiple output (SIMO) receiver for the demodulation of a quadrature amplitude modulated (QAM) signal of interest (SOI) corrupted by inter-symbol interference (ISI) and total noise composed of co-channel (CCI) interference and background noise. The receiver is derived under the assumption of a zero-mean, potentially noncircular, stationary, temporally and spatially colored Gaussian total noise. It is proved that this receiver is composed of a widely linear ﬁlter followed by a sampling operation at the symbol rate and a ML decision box implementing a modiﬁed version of the Viterbi algorithm. This WL ﬁlter is interpreted as a spatio-temporal matched ﬁl-ter (STMF) which maximizes the signal to interference plus noise ratio (SINR) on the current symbol. The case of quasi rectilinear modulation is also considered, where the MLSE receiver is proved to have a similar structure provided post rotation processing. Despite the fact that in practice, CCI are cyclostationary and non Gaussian, it is shown that the proposed receiver outperforms the conventional ones for cyclostationary and noncircular CCI.
University of Birmingham Reviewing the recent developments in idiopathic intracranial hypertension

There is increasing evidence and appreciation of idiopathic intracranial hypertension (IIH) in medicine. The pathological processes underlying raised intracranial pressure are being studied, with new insights found in both hormonal dysregulation and the metabolic neuroendocrine axis. These will potentially lead to novel therapeutic targets for IIH. The first consensus guidelines have been published on the investigation and management of adult IIH, and the International Headache Society criteria for headache attributable to IIH have been modified to reflect our evolving understanding of IIH. Randomized clinical trials have been published, and a number of studies in this disease area are ongoing.
New Questions, New Insights, New Approaches

qualitative pilot study on children’s use of new media carried out among Egyptian children from one urban and one rural area. One of the findings states that children from Fayoum – the rural area – use traditional media more than the children in Cairo. Building on Henry Jenkins’ (2009) work, José Manuel Pérez Tornero and Mireia Pi pro- pose a new style of media education based on new competences, critical understanding, cre- ativity and participation. This is the conclusion