Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel active compounds and the anti-diabetic mechanism of mulberry leaves

Mulberry (Morus alba L.) leaves have long been considered beneficial in traditional Chinese medicine to treat infectious and internal diseases. Recently studies have discovered that the mulberry leaf’s total flavonoids (MLF) display excellent hypoglycemia properties. However, the active ingredients and their molecular mechanisms are still uncharacterized. In this study, we explored the hypoglycemic effects of MLF and mulberry leaf polysaccharides (MLP) on ob/ob mice, an animal model of type 2 diabetes mellitus (T2DM), compared with Ramulus Mori (Sangzhi) alkaloid (RMA). Network pharmacology was employed to identify the potential available targets and active compounds of MLF and RMA against hyperglycemia. Molecular docking, an insulin-resistant cell model and qPCR were employed to verify the antidiabetic activity of the critical compounds and the gene expression profiles of the top molecular targets. Here, the results showed that MLF and MLP improved glucose uptake in insulin-resistant hepatocytes. MLF, MLP and RMA alleviated insulin resistance and glucose intolerance in ob/ob mice. Unlike MLF and MLP, RMA administration did not influence the accumulation of intrahepatic lipids. Network pharmacology analysis revealed that morusin, kuwanon C and morusyunnansin L are the main active compounds of MLF and that they amend insulin resistance and glycemia via the PI3K- Akt signaling pathway, lipid and atherosclerosis pathways, and the AGE-RAGE signaling pathway. Moreover, 1-deoxynojirimycin (DNJ), fagomine (FA), and N-methyl-1-deoxynojirimycin are the primary active ingredients of RMA and target carbohydrate metabolism and regulate alpha-glucosidase activity to produce a potent anti-diabetic effect. The molecular docking results indicated that morusin, kuwanon C and morusyunnansin L are the critical bioactive compounds of MLF. They had high affinities with the key targets adenosine A1 receptor (ADORA1), AKT serine/threonine kinase 1 (AKT1), peroxisome proliferator-activated receptor gamma (PPARγ), and glycogen synthase kinase 3 beta (GSK3β), which play crucial roles in the MLF-mediated glucose-lowering effect. Additionally, morusin plays a role in amending insulin resistance of hepatocytes by repressing the expression of the ADORA1 and PPARG genes. Our results shed light on the mechanism behind the glucose-lowering effects of MLF, suggesting that morusin, kuwanon C, and morusyunnansin L might be promising drug leads for the management of T2DM.
Higgs boson decay constraints on a model with a universal extra dimension

We investigate the impact of the latest data on Higgs boson branching ratios on the minimal model with a universal extra dimension. Combining constraints from vacuum stability requirements with these branching ratio measurements we are able to make realistic predictions for the signal strengths in this model. We use these to find a lower bound of 1.3 TeV on the size parameter ${R}^{\ensuremath{-}1}$ of the model at 95% confidence level, which is far more stringent than any other terrestrial bound obtained till now and is compatible with the dark matter constraints from the Wilkinson Microwave Anisotropy Probe data.
Intrapleural infusion of tumor cell-derived microparticles packaging methotrexate or saline combined with pemetrexed-cisplatin chemotherapy for the treatment of malignant pleural effusion in advanced non-squamous non-small cell lung cancer: A double-blind, randomized, placebo-controlled study

Background Preclincal studies showed the promising efficacy of tumor cell-derived microparticles packaging methotrexate (TMPs-MTX) to treat advanced non-squamous non-small cell lung cancer (NSCLC) with malignant pleural effusion (MPE). Methods This randomized, double-blind, placebo-controlled study was conducted at six hospitals in China from 20 July 2015 to 25 April 2019. Patients newly diagnosed with non-squamous NSCLC with MPE were randomly assigned to receive TMPs-MTX (group A) or saline (group B). Patients in both groups received pemetrexed (500 mg/m2 d1) and cisplatin (75 mg/m2 in total for d1-d2). Intrapleural infusion (50 mL saline containing 5 units of TMPs-MTX per perfusion, once every 48 hours, six total perfusions) was initiated on day 5 after pemetrexed-cisplatin chemotherapy. The primary outcome was the objective response rate (ORR) of MPE. Secondary outcomes included the ORR of target lesions, progression-free survival (PFS), overall survival (OS), toxicity, and pleural fluid properties. Results A total of 86 patients were enrolled in this study and randomly assigned to either group A or group B. Of these, 79 patients were evaluable for response. The ORR of MPE in group A was significantly higher than that in group B (82.50% vs. 58.97%, P = 0.0237). The ORR of target lesions was 25.64% in group A and 20.51% in group B (P = 0.5909), respectively. With a median follow-up time of 18.8 months, median PFS were 6.4 (95% CI, 4.5-12.3) months in group A and 7.3 (95% CI, 6.1-10.4) months in group B (P = 0.6893), and median OS were 19.9 (95% CI, 17.1-28.5) months and 17.5 (95% CI, 11.6-25.0) months (P = 0.4500), respectively. The incidence rates of adverse events were similar in the two groups. The most common treatment-related adverse events were chemotherapy-induced toxicities, including fever, gastrointestinal reactions, hepatic dysfunction, and leukopenia. Conclusion Intrapleural infusion of TMPs-MTX combined with pemetrexed-cisplatin chemotherapy is safe and effective against MPE in patients with advanced non-squamous NSCLC. Clinical trial registration http://www.chictr. org.cn (ChiCTR-ICR-15006304).
Swallowing function after acute ischemic stroke: Development and validation of a novel clinical prognostic model

Background Predicting the duration of dysphagia after acute ischemic stroke (AIS) is important for clinical treatment decisions. Objective The purpose of this study is to assess the swallowing function of AIS patients and to develop and validate a prognostic model for the need for nasogastric tube (NGT) in these patients. Materials and methods We included 554 AIS patients during 2018–2019 as the development group and had 186 AIS patients as the external validation group. The primary end point of the study was the retention of NGT in patients 1 week after admission (Functional Oral Intake Scale ≤ 4). Swallowing function and stroke-associated pneumonia (SAP) at 1 month post-onset were also the objectives of this study. The volume-viscosity swallow test (V-VST) was used to assess the patient’s impaired swallowing function. The Predictive model was built by logistic regression. Results Overall, a total of 104 patients required indwelling NGT at 1 week of AIS onset in development group. The final prognostic model includes 5 variables: age (OR: 1.085, 95%CI: 1.049–1.123), neutrophil-to-lymphocyte ratio (NLR) (OR: 1.332, 95%CI: 1.090–1.626), NIHSS (OR: 1.092, 95%CI: 1.025–1.164), history of drinking (OR: 2.532, 95%CI: 1.452–4.417) and stroke location (Subtentorial vs. Supratentorial, OR: 1.954, 95%CI: 1.088–3.509). The prediction model had an AUC of 0.810, while the external validation group was 0.794. Conclusion In stroke patients, it is very important to decide early whether to indwell a NGT. The nomogram will support decision making for NGT insertion and help these patients recover from their condition.
Cymbopogon citratus (DC.) Stapf aqueous extract ameliorates loperamide-induced constipation in mice by promoting gastrointestinal motility and regulating the gut microbiota

Slow transit constipation (STC) is the most common type of functional constipation. Drugs with good effects and few side effects are urgently needed form the treatment of STC. Cymbopogon citratus (DC.) Stapf (CC) is an important medicinal and edible spice plant. The wide range of biological activities suggested that CC may have laxative effects, but thus far, it has not been reported. In this study, the loperamide-induced STC mouse model was used to evaluate the laxative effect of the aqueous extract of CC (CCAE), and the laxative mechanism was systematically explored from the perspectives of the enteric nervous system (ENS), neurotransmitter secretion, gastrointestinal motility factors, intestinal inflammation, gut barrier and gut microbiota. The results showed that CCAE not only decreased the serum vasoactive intestinal polypeptide (VIP), induced nitric oxide synthases (iNOS), and acetylcholinesterase (AchE) in STC mice but also increased the expression of gastrointestinal motility factors in colonic interstitial cells of Cajal (ICCs) and smooth muscle cells (SMCs), thereby significantly shortening the defecation time and improving the gastrointestinal transit rate. The significantly affected gastrointestinal motility factors included stem cell factor receptor (c-Kit), stem cell factor (SCF), anoctamin 1 (Ano1), ryanodine receptor 3 (RyR3), smooth muscle myosin light chain kinase (smMLCK) and Connexin 43 (Cx43). Meanwhile, CCAE could repair loperamide-induced intestinal inflammation and intestinal barrier damage by reducing the expression of the pro-inflammatory factor IL-1β and increasing the expression of the anti-inflammatory factor IL-10, chemical barrier (Muc-2) and mechanical barrier (Cldn4, Cldn12, Occludin, ZO-1, and ZO-2). Interestingly, CCAE could also partially restore loperamide-induced gut microbial dysbiosis in various aspects, such as microbial diversity, community structure and species composition. Importantly, we established a complex but clear network between gut microbiota and host parameters. Muribaculaceae, Lachnospiraceae and UCG-010 showed the most interesting associations with the laxative phenotypes; several other specific taxa showed significant associations with serum neurotransmitters, gastrointestinal motility factors, intestinal inflammation, and the gut barrier. These findings suggested that CCAE might promote intestinal motility by modulating the ENS-ICCs-SMCs network, intestinal inflammation, intestinal barrier and gut microbiota. CC may be an effective and safe therapeutic choice for STC. Graphical Abstract CCAE might promote intestinal motility by modulating the ENS-ICCs-SMCs network, intestinal inflammation, intestinal barrier, and gut microbiota.
Power spectra of a constrained totally asymmetric simple exclusion process

In nature, all biological systems function in a far-from-equilibrium state. Here, we study the process of translation in protein synthesis, using the totally asymmetric simple exclusion process (TASEP) as a model. In particular, we explore the effects of a finite supply of particles for the TASEP, as in a living cell with a finite pool of ribosomes. Specifically, we investigate the power spectrum associated with total occupancy, utilizing both Monte Carlo simulations and theoretical analysis. New features arise, such as large suppressions at low frequencies, due to the added constraint. A theory is formulated based on a Langevin approach with discrete space and time. With good agreement between the simulation and theory, we gain some insights into the effects of finite resources on the TASEP.
Challenging Standard Non-Cooperative Game Theory? From Bacharach's "Variable Frame Theory" to "Team Reasoning"

The paper purports to stress how the two major contributions of Bacharach: "Variable Frame Theory" (VFT) and "Team Reasoning" (TR) improve Standard Non-Cooperative Game Theory in some relevant aspects which I point out. The aims are to show: (i) how Bacharach respectively justifies coordination and cooperation within these theories, and (ii) how these improvements in both VFT and TR involve a new conception of players and their rationality. I underline how coordination and cooperation rely on contextual and social determinants, which challenge and even contradict some pillars of standard individual rationality in terms of subjective expected utility, in games. Even if Bacharach's conceptual and methodological choices within these theories induce numerous difficulties, I try to show that Bacharach’s work underlines some of the implications and related problems induced by the mere foundations of standard non-cooperation game theory.
STRUCTURAL PHASE-TRANSITIONS IN C-70

Cubic as well as hexagonal single crystals of C70 have been grown and investigated by electron diffraction, electron microscopy and x-ray diffraction. Several phase transitions have been detected and crystallographic models are proposed. Hexagonal crystals, stable at room temperature with c/a = 1.63 will undergo two transitions, upon cooling. First the c/a ratio will increase to 1.82 owing to c-axis alignment of the molecules; at a lower temperature the molecules will orientationally order, resulting in a monoclinic structure.
An Energetic Variational Approach for ion transport

The transport and distribution of charged particles are crucial in the study of many physical and biological problems. In this paper, we employ an Energy Variational Approach to derive the coupled Poisson-Nernst-Planck-Navier-Stokes system. All physics is included in the choices of corresponding energy law and kinematic transport of particles. The variational derivations give the coupled force balance equations in a unique and deterministic fashion. We also discuss the situations with different types of boundary conditions. Finally, we show that the Onsager's relation holds for the electrokinetics, near the initial time of a step function applied field.
Galaxies as simple dynamical systems: observational data disfavor dark matter and stochastic star formation

According to modern theory, galactic evolution is driven by the dynamics of dark matter and stochastic star formation, but galaxies are observed to be simple systems. The existence of dark matter particles is a key hypothesis in present-day cosmology and galactic dynamics. Given the large body of high-quality work within the standard model of cosmology (SMoC), the validity of this hypothesis is challenged significantly by two independent arguments: (i) The dual dwarf galaxy theorem must be true in any realistic cosmological model. But the data now available appear to falsify this postulate when the dark-matter-based model is compared with the observational data. A consistency test for this conclusion comes from the significantly anisotropic distributions of satellite galaxies (baryonic mass <108M⊙) that orbit in the same direction around their hosting galaxies in disk-like structures, which cannot be derived from dark matter models. (ii) The action of dynamical friction due to expansive and massive dark m.
Star formation history and environment of the dwarf galaxy UGCA 92

We present a quantitative star formation history of the nearby dwarf galaxy UGCA 92. This irregular dwarf is situated in the vicinity of the Local Group of galaxies in a zone of strong Galactic extinction (IC 342 group of galaxies). The galaxy was resolved into stars, including the old red giant branch, with HST/ACS. We constructed a model of the resolved stellar populations and measured the star formation rate and metallicity as functions of time. The main star formation activity period occurred about 8–14 Gyr ago. These stars are mostly metal-poor, with a mean metallicity [Fe/H] ∼−1.5 to −2.0 dex. About 84 per cent of the total stellar mass was formed during this event. There are also indications of recent star formation starting about 1.5 Gyr ago and continuing to the present. The star formation in this event shows moderate enhancement from ∼200 to 300 Myr ago. It is very likely that the ongoing star formation period has a higher metallicity of about −0.6 to −0.3 dex. UGCA 92 is often considered to be the companion to the starburst galaxy NGC 1569. A comparison of our star formation history of UGCA 92 with that of NGC 1569 reveals no causal or temporal connection between recent star formation events in these two galaxies. We suggest that the starburst phenomenon in NGC 1569 is not related to the galaxy’s closest dwarf neighbours and does not affect their star formation history.
Siberian Cedar in Russian Business Naming: A Case Study

Business naming is important in the modern economy, but it can differ between countries. This makes it urgent to pay attention to representative examples of business naming (to be distinguished from brand naming) from different countries. This case study focuses on the usage of Siberian cedar in the names of Russian firms. This huge tree from taiga forests is not a true cedar, but pine. The national database permits the identification of 87 organizations named after Siberian cedar. Their geographical distribution is mapped, and their relation to industries is established. It is found that the considered firms are registered in 19 regions of Russia. A total of 42% of these regions are not Siberian, and they host 18% of the firms. A total of 16 types of activities characterize the considered firms, and more than half of the industries are not related to the usage of this tree. Hypothetically, these findings can be explained by the general interest of Russians in Siberia and their awareness of Siberian cedar coupled with the symbolic potential of this tree, which is able to symbolize stability and power. The studied principle of business naming contributes to the environmental knowledge of the public.
Synchronization in Finite Time of Fuzzy Neural Networks with Hybrid Delays and Uncertain Nonlinear Perturbations

is paper deals with the nite-time synchronization problem of a class of fuzzy neural networks with hybrid delays and uncertain nonlinear perturbations. By applying the famous nite-time stability theory, combining di erential inequality techniques, and the analysis approach, several new algebraic sucient criteria are obtained to realize nite-time synchronization between the drive system and the response system by designing a state feedback controller and an adaptive controller. Taking discrete delays, distributed delays, and uncertain nonlinear perturbations into account in fuzzy cellular neural networks makes the neural system more general than most existing cellular neural networks. Two di erent novel types of controllers designed to achieve nite-time synchronization can not only e ectively overcome the inuence of time delays and perturbations but also change their form according to the change of system state or perturbation to achieve a better control e ect. Meanwhile, some algebraic sucient criteria obtained in this paper can be proved by the parameters of the system itself, and the complex calculation of matrix inequality is avoided. Finally, the validity of our proposed results is con rmed by several examples and simulations. Furthermore, a secure communication problem is presented to further illustrate the fact of the obtained results.
Making an Ultracold Gas

We provide an introduction to the experimental physics of quantum gases. At the low densities of ultracold quantum gases, confinement can be understood from single-particle physics, and interactions can be understood from two-body physics. The structure of atoms provides resonances both in the optical domain and in the radio-frequency domain. Atomic structure data is given for the 27 atomic isotopes that had been brought to quantum degeneracy at the time this chapter was written. We discuss the motivations behind choosing among these species. We review how static and oscillatory fields are treated mathematically. An electric dipole moment can be induced in a neutral atom, and is the basis for optical manipulation as well as short-range interactions. Many atoms have permanent magnetic dipole moments, which can be used for trapping or long-range interactions. The Toronto $^{40}$K/$^{87}$Rb lattice experiment provides an illustration of how these tools are combined to create an ultracold, quantum-degenerate gas.
M APPING S PATIAL F REQUENCY P REFERENCES A CROSS H UMAN P RIMARY V ISUAL C ORTEX

Neurons in primate visual cortex (area V1) are tuned for spatial frequency, in a manner that depends on their position in the visual ﬁeld. Several studies have examined this dependency using fMRI, reporting preferred spatial frequencies (tuning curve peaks) of V1 voxels as a function of eccentricity, but their results differ by as much as two octaves, presumably due to differences in stimuli, measurements, and analysis methodology. Here, we characterize spatial frequency tuning at a millimeter resolution within human primary visual cortex, across stimulus orientation and visual ﬁeld locations. We measured fMRI responses to a novel set of stimuli, constructed as sinusoidal gratings in log-polar coordinates, which include circular, radial, and spiral geometries. For each individual stimulus, the local spatial frequency varies inversely with eccentricity, and for any given location in the visual ﬁeld, the full set of stimuli span a broad range of spatial frequencies and orientations. Over the measured range of eccentricities, the preferred spatial frequency is well-ﬁt by a function that varies as the inverse of the eccentricity plus a small constant. We also ﬁnd small but systematic effects of local stimulus orientation, deﬁned in both absolute coordinates and relative to visual ﬁeld location. Speciﬁcally, peak spatial frequency is higher for tangential than radial orientations and for horizontal than vertical orientations.
TITLE: Systemic sclerosis is a disease of a prematurely senescent, inﬂammatory and activated immunome

Systemic sclerosis (SSc) is an autoimmune disease characterised by excessive ﬁbrosis of skin and internal organs, and vascular dysfunction. Association of T and B cell subsets have been reported in SSc, however there is lack of systematic studies of functional relations between immune cell subsets in this disease. This lack of mechanistic knowledge hampers targeted intervention. In the current study we sought to determine differential immune cell composition and their interactions in peripheral blood of SSc patients. Mononuclear cells from blood of SSc patients and healthy controls (HC) were analysed by mass cytometry using a 36 marker (cell-surface and intracellular) panel. Transcriptome analysis (m-RNA sequencing) was performed on sorted T and B cell subsets. Unsupervised clustering analysis revealed signiﬁcant differences in the frequencies of T and B cell subsets in patients. Correlation network analysis highlighted an overall dysregulated immune architecture coupled with domination of inﬂammatory senescent T cell modules in SSc patients. Transcriptome analysis of sorted immune cells revealed an activated phenotype of CD4 and MAIT cells in patients, accompanied with increased expression of inhibitory molecules, reminiscent of phenotype exhibited by functionally adapted, exhausted T cells in response to chronic stimulation. Overall this study provides an in-depth analysis of the systemic immunome in SSc, highlighting the potential pathogenic role of inﬂammation and chronic stimulation mediated “premature senescence” of immune cells. receptors on CD4 and MAIT cells in our patients. In addition, correlation analysis of mass cytometry data, revealed an inverse correlation between PD1 expression and frequency of MAIT cells in SSc patients compared to healthy controls. In interpret-ing these data in a functional perspective, it must be underscored that expression of inhibitory receptors has been linked to reduced cytokine production by T cells in viral infections and cancer patients ((34), (35)). However, many recent studies have also shown that the expression of receptors like PD-1 does not correlate with lower functionality but rather differentiation state. True to this, our mass cytometry data showed an increased frequency of terminally differentiated subsets of CD27 - CD28 - T cells in patients. The combination of our high dimensionality data identiﬁed cell subsets reminiscent of functionally adapted, exhausted T cells in response to chronic stimulation.