Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterisation of anaemia amongst school going adolescent girls in rural Haryana, India

Abstract Objective: High burden of anaemia exists amongst rural adolescent girls in India. The objective of this study was to characterise anaemia in school going adolescent girls in rural Haryana, India. Design: Linear and multiple logistic regression analysis of data collected prior to an intervention trial was conducted. Participants were classified into anaemic (haemoglobin <12 g/dl) and non-anaemic group and were further classified into deficiencies of Fe, folate or vitamin B12, mixed, anaemia of other causes and inflammation. Setting: Three schools in Ballabgarh block of Faridabad District, Haryana, India. Participants: One hundered and ninety-eight non-anaemic and 202 anaemic adolescent girls (12–19 years). Results: Anaemic girls had 29·6 % Fe deficiency, 28·1 % folate or vitamin B12 deficiency, 15·8 % mixed deficiency and 9·7 % acute inflammation. Anaemia of other causes was found in 16·8 % of the anaemic participants. Girls with Fe and isolated folate deficiency had 2·5 times and four times higher odds of developing anaemia, respectively, as compared with non-anaemic girls. Fe deficiency with no anaemia was found amongst 11 % non-anaemic girls. Non-anaemic girls had a high prevalence of combined deficiency of folate or vitamin B12 (29·5 %) and acute inflammation (14·4 %). Conclusions: The current strategy of Fe and folic acid supplementation alone will not suffice for achieving the desired reduction in the prevalence of anaemia as unknown causes and anaemia of inflammation contribute to a substantial proportion of anaemia. Integrating other nutrition-specific components like improving water, sanitation and hygiene practices with the ongoing micronutrient supplementation program will comprehensively tackle anaemia. Unknown causes of anaemia warrant further research.
Comparison of Pericardiocentesis in Post-Cardiac Surgery and Nonsurgical Patients with Pericardial Tamponade

Introduction There are several approaches for pericardiocentesis. However, there is no definite suggestion about puncture location after cardiac surgery. The purpose of this study is to examine whether there is any difference regarding puncture location during pericardiocentesis in postoperative cardiac tamponade comparing to nonsurgical cardiac tamponade. Methods We retrospectively analyzed patients who had undergone pericardiocentesis from August 2011 to December 2019. Patients were examined in two groups, nonsurgical and postsurgical, based on the etiology of pericardial tamponade. Clinical profiles, echocardiographic findings, and procedural outcomes were identified and compared. Results Sixty-eight pericardiocenteses were performed in this period. The etiology of pericardial effusion was cardiac surgery in 27 cases and nonsurgical medical conditions in 41 cases. Baseline demographic variables were similar between the surgical and nonsurgical groups. Loculated effusion was more common in the postsurgical group (48.1% vs. 4.9%, P<0.001). Maximal fluid locations were different between the groups; right ventricular location was more common in the nonsurgical group (36.6% vs. 11.1%, P=0.02), while lateral location was more common in the postsurgical group (12.2% vs. 40.7%, P=0.007). Apical drainage was more frequently performed in the postsurgical group compared to the nonsurgical group (77.8% vs. 53.7%, P=0.044). Conclusion Apical approach as a puncture location can be used more frequently than subxiphoid approach for effusions occurred after cardiac surgery compared to nonsurgical effusions. Procedural success is prominent in this group and can be the first choice of treatment.
Psychosocial Intervention in Chronic Obstructive Pulmonary Disease: Meta-Analysis of Randomized Controlled Trials

ABSTRACT Objective Many patients with chronic obstructive pulmonary disease (COPD) experience persistent interrelated psychological and physical symptoms despite optimal treatment. Several studies of psychosocial intervention in COPD have been published in recent years. The present study aimed to conduct a quantitative summary of the efficacy of such interventions on psychological and physical outcomes. Methods Two independent raters screened PubMed, PsycINFO, Embase, Web of Science, Cochrane Library, and CINAHL for eligible studies. In all, 35 independent, randomized controlled trials with a total of 3,120 patients with COPD were included, assessed for their methodological quality, and subjected to meta-analytic evaluation. Results Meta-analyses revealed small, statistically significant effects of psychosocial intervention on combined psychological (Hedges’s g = 0.28; 95%CI: 0.16–0.41) and physical outcomes (g = 0.21; 95%CI: 0.07–0.35) with no indications of publication bias. Supplementary Bayesian meta-analyses provided strong evidence for a non-zero overall effect on psychological outcomes (Bayes factor (BF) = 305) and moderate support for physical outcomes (BF = 6.1). Exploring sources of heterogeneity with meta-regression indicated that older age of patients and longer duration of interventions were associated with smaller effects on psychological outcomes. Conclusions The results support psychosocial intervention as an additional, useful tool in multidisciplinary respiratory care with the potential to improve both psychological and physical outcomes. Future studies are recommended to monitor adverse effects, apply blinding of active control conditions, and determine sample sizes with a priori power calculations. Registration Registered with Prospero (www.crd.york.ac.uk/prospero/) prior to initiation of the literature search (Reg. ID: CRD42020170083).
Pseudomonas canavaninivorans sp. nov., isolated from bean rhizosphere.

A novel canavanine-degrading bacterium, strain HB002T, was isolated from rhizosphere soil of a catch crop field collected from the island of Reichenau in Konstanz, Germany, and characterized by using polyphasic taxonomy. The facultative aerobe, rod-shaped, Gram-stain-negative bacterium was oxidase- and catalase-positive. The isolate was able to grow on canavanine as a sole carbon and nitrogen source. Results of phylogenetic analysis based on 16S rRNA gene sequences revealed highest similarities to Pseudomonas bijieensis (L22-9T, 99.93 %), Pseudomonas brassicacearum subsp. neoaurantiaca (ATCC 49054T, 99.76 %), Pseudomonas brassicacearum subsp. brassicacearum (DBK 11T, 99.63 %), Pseudomonas thivervalensis (DSM 13194T, 99.51 %), Pseudomonas kilonensis (DSM 13647T, 99.39 %) and Pseudomonas corrugata (ATCC29736T, 99.39 %). Marker gene analysis placed the strain in the intrageneric group of Pseudomonas fluorescens, subgroup P. corrugata. In silico DNA-DNA hybridization and average nucleotide identity values were both under the recommended thresholds for species delineation. The predominant fatty acids of strain HB002T were C16 : 0, C17 : 0 cyclo ω7c and C18 : 1 ω7c. The major respiratory quinone was Q9, followed by Q8 and minor components of Q7 and Q10. Results from the phenotypic characterization showd the strain's inability to hydrolyse gelatin and to assimilate N-acetyl glucosamide and a positive enzymatic activity of acid phosphatase and naphthol-AS-BI phosphohydrolase that distinguish this strain from closely related type strains. Taken together, these results show that strain HB002T represents a novel species in the genus Pseudomonas, for which the name Pseudomonas canavaninivorans sp. nov. is proposed. The type strain is HB002T (=DSM 112525T=LMG 32336T).
Studies on Electromechanical foam material (EFOAM) as a potential Sensor and Actuator

A novel electromechanical foam (EFOAM) material capable of acting as an electromechanical transducer with integrated functions as a sensor - actuator is investigated by manufacturing some samples of the foam and performing some tests, based on the piezo-electric effect in electro-active polymers. The resulting charge, when different known weights are applied to the sample were observed and recorded with a charge amplifier while the actuator sensitivity was also estimated using the micro-scanning laser Doppler vibrometer. EFOAM is manufactured from expancel microspheres and heated by placing the microspheres in glass slides heated up to temperatures of 135 0 C for expansion. Different samples were manufactured and charged using the corona discharge method operating under an electric field of between 11kV/cm to 15kV/cm. EFOAM displayed an electro-mechanical sensitivity of 1nm/V when characterized, and is observed that the piezoelectric nature of EFOAM exists as a characteristic of each cell within the material sample. This novel material offers much promise in the area of production of miniature electromechanical devices which maybe well applied in electroacoustic applications.
Condensins are essential for Pseudomonas aeruginosa corneal virulence through their control of lifestyle and virulence programs

Pseudomonas aeruginosa is a significant opportunistic pathogen responsible for numerous human infections. Its high pathogenicity resides in a diverse array of virulence factors and an ability to adapt to hostile environments. We report that these factors are tied to the activity of condensins, SMC and MksBEF, which primarily function in structural chromosome maintenance. This study revealed that both proteins are required for P. aeruginosa virulence during corneal infection. The reduction in virulence was traced to broad changes in gene expression. Transcriptional signatures of smc and mksB mutants were largely dissimilar and non‐additive, with the double mutant displaying a distinct gene expression profile. Affected regulons included those responsible for lifestyle control, primary metabolism, surface adhesion and biofilm growth, iron and sulfur assimilation, and numerous virulence factors, including type 3 and type 6 secretion systems. The in vitro phenotypes of condensin mutants mirrored their transcriptional profiles and included impaired production and secretion of multiple virulence factors, growth deficiencies under nutrient limiting conditions, and altered c‐di‐GMP signaling. Notably, c‐di‐GMP mediated some but not all transcriptional responses of the mutants. Thus, condensins are integrated into the control of multiple genetic programs related to epigenetic and virulent behavior of P. aeruginosa.
Successful treatment of canine infective endocarditis caused by Bacillus amyloliquefaciens

Abstract Bacillus amyloliquefaciens is a gram-positive bacterial species that is utilised as a probiotic in humans and animals. There are no reports of infective endocarditis (IE) in dogs. An 8-year-old, spayed, female Maltese presented with a 1-month history of fever, depression, weight loss, and hindlimb lameness. Laboratory test results indicated non-regenerative anaemia, neutrophilia, hyperglobulinemia, and proteinuria. Echocardiography revealed vegetation on the septal leaflet of the mitral valve and thromboemboli in the left atrium. Consecutive blood culture results revealed that the blood samples were consistently positive for Bacillus amyloliquefaciens, which is generally considered a probiotic bacterial species for animals. Broad-spectrum antibiotics (amoxicillin-clavulanic acid and cefotaxime) and anticoagulants (clopidogrel and rivaroxaban) were administered for 4 months. The clinical signs were responsive to antibiotic treatment. After 4 months, the dog was no longer febrile and the size of the thromboemboli in the left atrium had decreased. Bacteria were no longer isolated in blood cultures after antibiotic therapy. To the best of our knowledge, this is the first case report of canine IE caused by bactaeremic infection with Bacillus amyloliquefaciens.
Informed Consent In Facial Photograph Publishing: A Cross-sectional Pilot Study To Determine The Effectiveness Of Deidentification Methods

This study determined the effectiveness of three deidentification methods: use of a) a black box to obscure facial landmarks, b) a letterbox view to display restricted facial landmarks and c) a half letterbox view. Facial images of well-known celebrities were used to create a series of decreasingly deidentified images and displayed to participants in a structured interview session. 55.5% were recognised when all facial features were covered using a black box, leaving only the hair and neck exposed. The letterbox view proved more effective, reaching over 50% recognition only once the periorbital region, eyebrows, and forehead were visible. The half letterbox was the most effective, requiring the nose to be revealed before recognition reached over 50%, and should be the option of choice where appropriate. These findings provide valuable information for informed consent discussions, and we recommend consent to publish forms should stipulate the deidentification method that will be used.
Hydrologic and Water Quality Models: Performance Measures and Evaluation Criteria

Performance measures (PMs) and corresponding performance evaluation criteria (PEC) are important aspects of calibrating and validating hydrologic and water quality models and should be updated with advances in modeling science. We synthesized PMs and PEC from a previous special collection, performed a meta-analysis of performance data reported in recent peer-reviewed literature for three widely published watershed-scale models (SWAT, HSPF, WARMF), and one field-scale model (ADAPT), and provided guidelines for model performance evaluation. Based on the synthesis, meta-analysis, and personal modeling experiences, we recommend coefficient of determination (R2; in conjunction with gradient and intercept of the corresponding regression line), Nash Sutcliffe efficiency (NSE), index of agreement (d), root mean square error (RMSE; alongside the ratio of RMSE and standard deviation of measured data, RSR), percent bias (PBIAS), and several graphical PMs to evaluate model performance. We recommend that model performance can be judged satisfactory for flow simulations if monthly R2 0.70 and d 0.75 for field-scale models, and daily, monthly, or annual R2 0.60, NSE 0.50, and PBIAS ≤ ±15% for watershed-scale models. Model performance at the watershed scale can be evaluated as satisfactory if monthly R2 0.40 and NSE 0.45 and daily, monthly, or annual PBIAS ≤ ±20% for sediment; monthly R20.40 and NSE 0.35 and daily, monthly, or annual PBIAS ≤ ±30% for phosphorus (P); and monthly R2 0.30 and NSE 0.35 and daily, monthly, or annual PBIAS ≤ ±30% for nitrogen (N). For RSR, we recommend that previously published PEC be used as detailed in this article. We also recommend that these PEC be used primarily for the four models for which there were adequate data, and used only with caution for other models. These PEC can be adjusted within acceptable bounds based on additional considerations, such as quality and quantity of available measured data, spatial and temporal scales, and project scope and magnitude, and updated based on the framework presented herein. This initial meta-analysis sets the stage for more comprehensive meta-analysis to revise PEC as new PMs and more data become available.
Ultrasensitive Multimodal Tactile Sensors with Skin‐Inspired Microstructures through Localized Ferroelectric Polarization

Abstract Multifunctional electronic skins have attracted considerable attention for soft electronics including humanoid robots, wearable devices, and health monitoring systems. Simultaneous detection of multiple stimuli in a single self‐powered device is desired to simplify artificial somatosensory systems. Here, inspired by the structure and function of human skin, an ultrasensitive self‐powered multimodal sensor is demonstrated based on an interlocked ferroelectric copolymer microstructure. The triboelectric and pyroelectric effects of ferroelectric microstructures enable the simultaneous detection of mechanical and thermal stimuli in a spacer‐free single device, overcoming the drawbacks of conventional devices, including complex fabrication, structural complexity, and high‐power consumption. Furthermore, the interlocked microstructure induces electric field localization during ferroelectric polarization, leading to enhanced output performance. The multimodal tactile sensor provides ultrasensitive pressure and temperature detection capability (2.2 V kPa−1, 0.27 nA °C−1) over a broad range (0.1–98 kPa, −20 °C < ΔT < 30 °C). Furthermore, multiple simultaneous stimuli can be distinguished based on different response times of triboelectric and pyroelectric effects. The remarkable performance of this sensor enables real‐time monitoring of pulse pressure, acoustic wave detection, surface texture analysis, and profiling of multiple stimuli.
Typology of Family Relationships, Psychological Distress, and Quality of Life in Chinese Patients With Advanced Lung Cancer

Background Family relationships affect psychological adjustment and quality of life (QoL) in patients with advanced cancer. The typology of family relationships has not been examined in Chinese patients with advanced cancer. Objective The aims of this study were to identify profiles of family relationships and examine their relationships with psychological distress and QoL in Chinese patients with advanced lung cancer. Methods A total of 252 Chinese patients with advanced lung cancer at 2 hospitals in Shanghai participated in the study. They completed self-reported questionnaires. Latent profile analysis was used to identify the optimal classification of perceived family relationships based on 3 indicators (cohesiveness, expressiveness, and conflict resolution). Results Three profiles of family relationships were identified. The supportive profile (70.6%) showed high cohesiveness, expressiveness, and conflict resolution. The low-expressive profile (15.9%) showed low expressiveness but high cohesiveness and conflict resolution (15.9%). The conflictive profile (13.5%) showed low conflict resolution but high cohesiveness and expressiveness. Compared with supportive families, low-expressive and conflictive families were associated with worse depressive symptoms and anxiety symptoms, which could result in poorer QoL. Conclusions Cohesiveness, expressiveness, and conflict resolution could be used to identify family relationship typology in Chinese patients with advanced lung cancer. Family relationship typology was associated with psychological distress and QoL. Implications for Practice The findings indicate a need for screening families and provide culturally sensitive family interventions to effectively support families at risk of poor outcomes.
Whether Mirror and Conceptual Neurons are Myths? Sparse vs. Distributed Neuronal Representations

ABSTRACT Multi-layer neural networks, mirror neurons, and gnostic neurons are concepts that assign neural representations to mental representations of percepts and inner sensations. However, none of these approaches alone can explain the higher mental functions, which we observe in natural minds from the third and first-person perspectives through introspection. Recent concepts of preservation of chemical traces of sensory stimuli and hierarchical structures of postsynaptic associations represented by specifically organized groups of neurons combine these concepts and effectively explain much more complex mental functions. To find an operative model and understand how knowledge in the mind creates conscious sensations, we explain how perceptions, sensory impressions, and environment models gain their neural representations. It was pointed out ways to detect the similarity of structures representing previously remembered patterns to the mental and neuronal representations of new perceptions, ways of their associations, and principles of information processing. Supplemented, presented in earlier works, concepts of competition of representations stimulation and factors stimulating their action explain the mind’s complex functions, including speech production and recognition. We postulate that using new methods of modelling the neural network’s functions through the parallel physical process allows creating a physical model of natural and artificial, conscious, intelligent minds.
Brain DNA damage analysis in pesticide exposed wistar albino rats (Rattus norvegicus): a chemometric approach

Abstract Brain the most important organ which controls most of the regulations in the body is composed of neurons and glia. As brain has a high metabolic rate and reduced cell renewal capability, the lipids, proteins and nucleic acids become the major targets of damage. In the present study carbofuran (CF) induced brain DNA damage in male wistar albino rats at sub-lethal doses (Control-A; B-1.0, C-0.5 and D-0.3 mg/kg BW) while the groups B1,C1, D1, B2, C2, D2 and B3, C3, D3 represents the exposure duration 30, 60 and 90 days each respectively. FTIR spectroscopy based chemometric analysis of functional groups in nucleic acids are reported, changes in band area and band frequencies were examined to understand the DNA damage by constructing heat map. Significant changes were observed in the band frequency, band areas, bandwidth and intensity values (p < 0.05, 0.01, 0.001). The principal component analysis was analyzed to study the alterations at the molecular level, which revealed maximum variance of 74% in groups A, B1, C1, D1 and C2 and 13.7% variance in B2, D2, B3, C3 and D3. The present study provides significant details to analyse DNA damage using non-conventional approach and can also be used for detecting DNA damage in several neural diseases and disorders and emphasizes on using FTIR spectral data through chemometric approach to analyse the DNA damage. Communicated by Ramaswamy H. Sarma.
FN-Net: Remove the Outliers by Filtering the Noise

Establishing the correspondence between two images is an important research direction of computer vision. When estimating the relationship between two images, it is often disturbed by outliers. In this paper, we propose a convolutional neural network that can filter the noise of outliers. It can output the probability that the pair of feature points is an inlier and regress the essential matrix representing the relative pose of the camera. The outliers are mainly caused by the noise introduced by the previous processing. The outliers rejection can be treated as a problem of noise elimination, and the soft threshold function has a very good effect on noise reduction. Therefore, we designed an adaptive denoising module based on soft threshold function to remove noise components in the outliers, to reduce the probability that the outlier is predicted to be an inlier. Experimental results on the YFCC100M dataset show that our method exceeds the state-of-the-art in relative pose estimation.