Miracle-dz/UniFAR-FTUs huggingface dataset:
New Era of Electroceuticals: Clinically Driven Smart Implantable Electronic Devices Moving towards Precision Therapy

In the name of electroceuticals, bioelectronic devices have transformed and become essential for dealing with all physiological responses. This significant advancement is attributable to its interdisciplinary nature from engineering and sciences and also the progress in micro and nanotechnologies. Undoubtedly, in the future, bioelectronics would lead in such a way that diagnosing and treating patients’ diseases is more efficient. In this context, we have reviewed the current advancement of implantable medical electronics (electroceuticals) with their immense potential advantages. Specifically, the article discusses pacemakers, neural stimulation, artificial retinae, and vagus nerve stimulation, their micro/nanoscale features, and material aspects as value addition. Over the past years, most researchers have only focused on the electroceuticals metamorphically transforming from a concept to a device stage to positively impact the therapeutic outcomes. Herein, the article discusses the smart implants’ development challenges and opportunities, electromagnetic field effects, and their potential consequences, which will be useful for developing a reliable and qualified smart electroceutical implant for targeted clinical use. Finally, this review article highlights the importance of wirelessly supplying the necessary power and wirelessly triggering functional electronic circuits with ultra-low power consumption and multi-functional advantages such as monitoring and treating the disease in real-time.
Value based pricing of distribution generations active power in distribution networks

With widespread installation of distribution generations (DG) mainly in distribution networks, a fairly incentive scheme is required to better meet the investment and innovation challenge and to drive the innovation needed to deliver a sustainable energy network with value for money to existing and future consumers. This study proposes a new method to determine DG energy price based on its impact on active loss reduction. This method calculates the actual value of each DG in the active loss reduction and according to this value, determines DG energy price, which is named value based pricing. The proposed approach is applied to a market model with two different agents, namely considered as the distribution company (DisCo) and the owner of DG. In this model, the DisCo is considered as the sole owner and operator of a distribution network and can purchase energy from the wholesale electricity market and/or from DG units owned by independent producers. To illustrate the advantages of the proposed method compared with the local marginal pricing(, both methods are implemented in 33-bus distribution network.
Application of Z score analysis in evaluating steel industry in India

The paper is an empirical study to understand the financial soundness of steel industry in India. For this purpose twenty large and medium steel units which are listed are taken. A sample period of 2001 - 2010 was selected for the study. The financial performance of the Steel industry was monitored and measured by using Altman's Z-score model which was extensively used by practitioners and researchers in the past. This study analyses the possibility of business failure with reasonable accuracy by using the z-score model. The research findings are that the steel industry is in good financial performance inspite of the impact of sluggish demand and global economic slowdown with an exception of two companies in the study period.
Vacuum Suction Cup Modeling for Evaluation of Sealing and Real-Time Simulation

In this letter, we propose a method of computationally efficient modeling of vacuum suction grippers. The model is better at predicting the load-carrying capability of a vacuum suction cup while being easy to simulate in a virtual environment. The contact geometry between the suction cup and the curved surface of the handling object is analyzed to compute the deformation and the distributed force between them. We break down the deformation of the suction cup into two corresponding forces, compression force and bending force where the former is the deformation of the cup related to axial direction and the latter is modeled by a beam deflection with fixed ends. Our modeling leads to conditions for seal formation. In our experimental tests, the model was able to accurately predict the load-carrying capabilities for suction grasps on simple as well as curved surfaces. The model was also implemented into a robotic simulator, CoppeliaSim, where the deformation and the state of the suction grasp can be simulated in real-time.
Genetic Manipulation and Bioreactor Culture of Plants as a Tool for Industry and Its Applications

In recent years, there has been a considerable increase in interest in the use of transgenic plants as sources of valuable secondary metabolites or recombinant proteins. This has been facilitated by the advent of genetic engineering technology with the possibility for direct modification of the expression of genes related to the biosynthesis of biologically active compounds. A wide range of research projects have yielded a number of efficient plant systems that produce specific secondary metabolites or recombinant proteins. Furthermore, the use of bioreactors allows production to be increased to industrial scales, which can quickly and cheaply deliver large amounts of material in a short time. The resulting plant production systems can function as small factories, and many of them that are targeted at a specific operation have been patented. This review paper summarizes the key research in the last ten years regarding the use of transgenic plants as small, green biofactories for the bioreactor-based production of secondary metabolites and recombinant proteins; it simultaneously examines the production of metabolites and recombinant proteins on an industrial scale and presents the current state of available patents in the field.
On the Estimation of Directional Wave Spectrum Based on Stationary Vessels 1st Order Motions: A New Set of Experimental Results

The practicability of estimating directional wave spectra based on a vessel 1st order response has been recently addressed by several researchers. The interest is justified since on-board estimations would only require only a simple set of accelerometers and rate-gyros connected to an ordinary PC. The on-board wave inference based on 1st order motions is therefore an uncomplicated and inexpensive choice for wave estimation if compared to wave buoys and radar systems. The latest works in the field indicate that it is indeed possible to obtain accurate estimations and a Bayesian inference model seems to be the preferable method adopted for performing this task. Nevertheless, most of the previous analysis has been based exclusively on numerical simulations. At Polytechnic School, an extensive research program supported by Petrobras has been conducted since 2000, aiming to evaluate the possibility of estimating wave spectrum on-board offshore systems, like FPSO platforms. In this context, a series of small-scale tests has been performed at the LabOceano wave basin, comprising long and short crested seas. A possible candidate for on-board wave estimation has been recently studied: a crane barge (BGL) used for launching ducts offshore Brazil. The 1:48 model has been subjected to bow and quartering seas with different wave heights and periods and also different levels of directional spreading. A Bayesian inference method was adopted for evaluating the wave spectra based on the time-series of motions and the results were directly compared to the wave spectra measured in the basin by means of an array of wave probes. Very good estimations of the statistical parameters (significant wave height, peak period and mean wave direction) were obtained and, in most cases, even the directional spreading could be properly predicted. Inversion of the mean direction (180° shift), mentioned by some authors as a possible drawback of the Bayesian inference method, was not observed in any case. Sensitivity analysis on errors in the input parameters, such as the vessel inertial characteristics, has also been performed and attested that the method is robust enough to cope well with practical uncertainties. Overall results once again indicate a good performance of the inference method, providing an important additional validation supported by a large set of model tests. © 2008 ASME
ABELIAN DIFFERENCE SETS AS LATTICE COVERINGS AND LATTICE TILINGS

Abstract We demonstrate that every difference set in a finite Abelian group is equivalent to a certain ‘regular’ covering of the lattice $ A_n = \{ \boldsymbol {x} \in \mathbb {Z} ^{n+1} : \sum _{i} x_i = 0 \} $ with balls of radius $ 2 $ under the $ \ell _1 $ metric (or, equivalently, a covering of the integer lattice $ \mathbb {Z} ^n $ with balls of radius $ 1 $ under a slightly different metric). For planar difference sets, the covering is also a packing, and therefore a tiling, of $ A_n $ . This observation leads to a geometric reformulation of the prime power conjecture and of other statements involving Abelian difference sets.
A Visual Display of Flight Time and Distance

A flight simulation study was conducted to examine the effect of a visual display of flight time and distance added to a pathway prediction symbology on pilot's flight time management. Twelve participants flew a standard flight path with a time-constrained landing task. Some conditions such as flight under various wind and visibility levels, or instrumentation failures were also applied to the flight tests to measure performance in more challenging conditions. We measured flight's time error as our measure in this study. The results showed that participants flew more accurate flights and landed closer to the required landing time with the visual display particularly under challenging conditions. We concluded that the enhancements made to the pathway prediction display by adding the time-distance gauge supported improved flight time management and flight control.
Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders

Cardoon (Cynara cardunculus L.) is a Mediterranean plant and member of the Asteraceae family that includes three botanical taxa, the wild perennial cardoon (C. cardunculus L. var. sylvestris (Lamk) Fiori), globe artichoke (C. cardunculus L. var. scolymus L. Fiori), and domesticated cardoon (C. cardunculus L. var. altilis DC.). Cardoon has been widely used in the Mediterranean diet and folk medicine since ancient times. Today, cardoon is recognized as a plant with great industrial potential and is considered as a functional food, with important nutritional value, being an interesting source of bioactive compounds, such as phenolics, minerals, inulin, fiber, and sesquiterpene lactones. These bioactive compounds have been vastly described in the literature, exhibiting a wide range of beneficial effects, such as antimicrobial, anti-inflammatory, anticancer, antioxidant, lipid-lowering, cytotoxic, antidiabetic, antihemorrhoidal, cardiotonic, and choleretic activity. In this review, an overview of the cardoon nutritional and phytochemical composition, as well as its biological potential, is provided, highlighting the main therapeutic effects of the different parts of the cardoon plant on metabolic disorders, specifically associated with hepatoprotective, hypolipidemic, and antidiabetic activity.
The Effect of Glucosinolates on the Growth and Development of Helicoverpa armigera Larvae and the Expression of Midgut Sulfatase Genes

The plant–pest interaction and its mechanisms are a novel research direction for pest control. They provide molecular targets for developing new pesticides and targeted control measures to control insect herbivores. Glucosinolate is a large family of secondary substances found in cruciferous plants that are harmful to herbivorous insects. Specialist herbivores have developed specific anti-defense genes and detoxifying mechanisms against glucosinolate from the host plant, but how generalist herbivores respond to glucosinolate at the molecular level is unknown. In this study, we investigated the effects of different glucosinolate concentrations on the growth and development of Helicoverpa armigera. Moreover, the expression of sulfatase genes (HaSulfs) was also checked following exposure to glucosinolate concentrations. The developmental duration of larvae and pre-pupa of H. armigera was significantly increased by 14.79–25.03% after feeding glucosinolate compared to the control. Quantitative Real-Time PCR (RT-qPCR) was carried out to analyze the expression of HaSulf family genes in the midgut of fifth instar larvae of H. armigera. The results showed that the upregulated expression patterns of HaSulf family genes were diversified after feeding at different concentrations. The expression level of HaSulf was detected with the HaSulf antibody. Only the glucosinolate-fed larvae had a visible target band and were mainly distributed in the midgut wall. Taken together, glucosinolate can significantly affect the growth and development of H. armigera larvae. It can induce the expression of HaSulf in the midgut of H. armigera at gene and protein levels. This study could be useful to understand the development of plant-derived insecticides resistance in H. armigera.
Metabarcoding reveals massive species diversity of Diptera in a subtropical ecosystem

Abstract Diptera is often considered to be the richest insect group due to its great species diversity and broad ecological versatility. However, data on dipteran diversity from subtropical ecosystems have hitherto been scarce, due to the lack of studies conducted at an appropriate large scale. We investigated the diversity and composition of Diptera communities on Tianmu Mountain, Zhejiang, China, using DNA metabarcoding technology, and evaluated their dynamic responses to the effects of slope aspect, season, and altitudinal zone. A total of 5,092 operational taxonomic units (OTUs) were discovered and tentatively assigned to 72 dipteran families, including 2 family records new for China and 30 family records new for the locality. Cecidomyiidae, Sciaridae, and Phoridae were the predominant families, representing 53.6% of total OTUs, while 52 families include >95% unidentified and presumed undescribed species. We found that the community structure of Diptera was significantly affected by aspect, seasonality (month) and elevation, with richer diversity harbored in north‐facing than south‐facing slopes, and seasonality a more profound driver of community structure and diversity than elevation. Overall, massive species diversity of Diptera communities was discovered in this subtropical ecosystem of east China. The huge diversity of potentially undescribed species only revealed by metabarcoding now requires more detailed taxonomic study, as a step toward an evolutionary integration that accumulates information on species’ geographic ranges, ecological traits, functional roles, and species interactions, and thus places the local communities in the context of the growing knowledge base of global biodiversity and its response to environmental change.
Management and Outcome of Ruptured Anterior Circulation Cerebral Aneurysms – An Experience of Neurosurgery Department of Nawabshah

Objectives: To analyze the management and outcome of ruptured anterior cerebral circulation aneurysm by a variety of procedures including microsurgical clipping. Material and Methods: A quasi-experimental study, carried out in The Department of Neurosurgery, Peoples’ Medical University Hospital Nawabshah from November 2010 to December 2020.We enrolled 38 patients and 40 aneurysms who presented with ruptured aneurysms. Hunt and Hess grading was used to evaluate the neurological status and ruptured aneurysms were managed by microsurgical clipping, excision, and suture ligation. Results: Out of 38 patients Male were (23) 61% and females were (15) 39%, with a mean age of 50±25 years with aneurysmal subarachnoid hemorrhage and graded according to Hunt and Hess grade and fissure grading. Middle cerebral artery aneurysm was 45%, Anterior communicating artery 30%, Anterior Cerebral Artery 10%, carotid bifurcation 2.5%. Multiple aneurysms at internal carotid plus anterior communicating artery (n = 2) and internal carotid plus middle cerebral artery aneurysms n = 2. Distal anterior cerebral (n = 1). In 33 patients, the aneurysm was clipped, in 3 patients with fissure grading 4 and huge intracerebral bleed with signs of brain herniation, decompression plus aneurysm clipping was done, suture ligation (n = 1) and excision of a giant aneurysm (n = 3). Conclusions: Microsurgical clipping is considered an ideal modality to secure a ruptured intracerebral aneurysm. Rarely it can be amendable by suture ligation, or excision. Presenting Hunt and Hess, fissure grading, age, and volume of intracerebral bleed have a direct impact on prognosis.
The New Deal for New Americans: Immigration Status and Mental Health

Extreme circumstances immigrants experience causes them to have a higher risk for mental health problems. It gets even more severe for refugees than host populations and other migrant groups. Thus, in this paper, mental health disparities between native-born citizens and refugees in the US will be investigated by considering social policies. Firstly, immigration status in the US will be investigated in terms of its relation to mental health. Then, mental health will be examined, and the focus will be on anxiety disorders and depression as these are the two common disorders among refugees. In the following section, Social-Ecological Model will be used as a framework to explain the relationship between immigration status and mental health. The Refugee Act of 1980 and The New Deal for New Americans Act will be used to understand the current political climate in terms of the refugee situation in the US, and we will examine how this has an impact on refugees' mental health. This paper will be concluded after mentioning the obstacles and the recommendations.
Efficient Anonymous Authentication for Wireless Body Area Networks

Advances in integrated circuit and wireless communication technologies are making wireless body area networks (WBANs) an increasingly important medical paradigm. By collecting, uploading, and processing real-time physical parameters, WBANs assist clients in better recognizing and managing their bodies. Besides conveniences it brings, WBANs are facing the risk of clients’ privacy leakage during data transmission. Anonymous authentication schemes were proposed to resolve this challenge, and latest schemes ensure that even if a WBAN client’s private key is exposed, previous session keys generated by this client cannot be compromised (known as forward security). Unfortunately, previous forward secure schemes need bilinear pairing operations, which is undesirable in computation-resource-bounded WBANs. Furthermore, the property, that once a WBAN client’s private key is exposed, previous sessions shouldn’t be identified (dubbed forward anonymity), hasn’t been considered in existing works. In response to the above challenges, in this paper, we propose an identity-based authenticated encryption method without pairing, and based on this method, we construct an anonymous authentication scheme. Subsequent security and performance analyses demonstrate that our schemes are secure (including forward anonymous) under the random oracle model, and practical in WBANs with limited resources.
Dielectric Constant Detection by Using a New Microstrip Ring Resonator System

An essential property of dielectric materials is a dielectric constant. In dielectric measurement, microwave sensors are widely used for electromagnetic radiation of the microwave region. Microwave dielectric measurement methods generally fall into two categories: non-resonant and resonant methods. Resonant methods have relatively higher accuracy than non-resonant ones [1]– [2]. For measurement, the sample is introduced into a resonator thus altering the electromagnetic boundaries of the resonator, and the electromagnetic properties of the sample are deduced from the change of the resonant properties of the resonator. Due to its high accuracy and its flexibility in sample preparation, the resonant method is widely used for low-loss samples, small size samples and samples of irregular shapes. In sensors structure, the sensors based on waveguide and coaxial lines are bulky and are not convenient for integration with electronic circuits. Planar transmission lines are used in order to develop compact sensors [3]. The planar resonator structure is very simple, low cost, and easy to remove samples. Several investigators have used microstrip resonators for determination of dielectric constant of materials. Sarabandi and Li [4] used a microstrip ring resonator for measurement of soil dielectric parameters. The dielectric constant of a soil medium can be computed by using a resonant frequency shift. And moisture content as high as 40% can be measured with the dielectric constant technique. The dielectric material can be determined from each mode of resonant frequency and relates to an effective dielectric constant as following equation. fr = nc/(Leff eff e )
Modellgestützte Regelungskonzepte: Ein Vergleich

Literatur [1] Hauser, H. , et al.: Inducibility of human /3-Interferone gene in mouse L-cell clones. Nature 297 (1982), S. 650-655. [2] Hauser, H. , Dinter, H. , und Collins, J.: Construction of interferon-producing mouse cell lines by genetic engineering. 3rd European Congress on Biotechnology 1984. Vol. III, S. 279. [3] Lehmann, J., Piehl, G. -W. und Schulz, R. : Blasenfreie Zellkulturbegasung mit bewegten, porösen Membranen. BTF-BIOTECHFORUM 2 (1985), S. 113-117. [4] Lehmann, J.: Zellkultur-Reaktortechnik für tierische und pflanzliche Zellen. Sonderdruck Nr. 113.2. 85, Fa. Diessel, Hildesheim 1986. [5] Luttmann, R. , Munack, Α. , und Thoma, MMathematical Modelling, Parameter Identification and Adaptive Control of Single Cell Protein Processes in Tower Loop Bioreactors. In: Fiechter, A. (Herausgeber): Advances in Biochemical Engineering/Biotechnology 32 (1985), S. 95-205. [6] Reuß, M. : Transportphänomene in Bioreaktoren. In Handbuch zum DECHEMA-Grundkursus Biotechnologie, GBF-Braunschweig 1979. [7] Bergter, F. : Wachstum von Mikroorganismen. 2. Auflage. Verlag Chemie, Weinheim 1983. [8] Freier, R.K. : Wäßrige Lösungen, Daten für anorganische und organische Verbindungen. Band 2: Ergänzungen. Verlag: Walter de Gruyter. Berlin 1978. [9] Schulz, R. Krafft, H. , und Lehmann, J.: Prozeßführung bei der Produktion von rekombinantem humanem ^-Interferon mit Mausfibroblasten. Chemie Technik 15 (1986), S. 70-75.
Evaluating new gerontechnologies: Proof of concept is necessary, but not sufficient

Background At a minimum, evaluation of a gerontechnology requires two steps: (i) a proof of concept demonstration that the product can operate as intended; and (ii) a demonstration that targeted aging and aged users can, want to, and will use the product as intended to achieve the ends as advertised. The second step is the more difficult; the present article describes some practical procedures for measuring the effect of the product on the individual’s behavior. Methods Single Case Experimental Designs (SCED) allow for efficient evaluation of a product by a small number of users; SCED are especially useful when one or very few prototypes are available for evaluation. Results The basic elements of SCEDs include a no-treatment baseline periods alternating with periods in which the gerontechnology is introduced, with the baseline phase representing a period in which the feature of the product being evaluated is disabled; measurable changes in user behavior with vs. without the product feature enabled constitutes the evaluation. Examples illustrating some ways the basic elements can be implemented are provided. Conclusions SCEDs provide a good alternative to the more expensive and complex Randomized Controlled Trials (RCTs) generally considered the ‘gold standard’ for evaluations.