Miracle-dz/UniFAR-FTUs huggingface dataset:
Core Signs and Symptoms in Children with Autism Spectrum Disorder Improved after Starting Risperidone and Aripiprazole in Combination with Standard Supportive Therapies: A Large, Single-Center, Retrospective Case Series

Abstract Background: There are a number of medications prescribed to address comorbid challenging behaviors in children with autism spectrum disorder (ASD), including risperidone and aripiprazole. This retrospective case series reports the use of these drugs in children aged 2 to 13 years. Methodology: A total of 82 children (mean age, 5 years; 79% male) with ASD treated at the Kids Neuro Clinic and Rehab Center in Dubai between January 2020 and September 2021 were included in this retrospective case series. All patients had comorbid challenging behaviors that were resistant to standard supportive therapies alone and warranted pharmacological intervention. The Childhood Autism Rating Scale—2nd Edition Standard form (CARS2-ST) and the Clinical Global Impression (CGI)—Severity (CGI-S) and CGI—Improvement (CGI-I) scales were used to assess the severity of ASD at baseline and to monitor response to treatment with risperidone or aripiprazole. Results: Besides the expected improvement in comorbid challenging behaviors, 79/82 patients (96%) attained a CGI-I score of 2 or 1 following treatment, and 35/82 patients (43%) achieved both a CGI-I score of 1 and minimal-to-no symptoms as per the CARS2-ST test, with complete resolution of their ASD signs and symptoms. The differences in the overall mean CARS2-ST and CGI-S scores pre- and post-treatment were statistically significant (Z = −7.86, p < 0.0001 for both), with pre- and post-treatment mean values of 42 and 23 for CARS2-ST, respectively, and 6 and 2 for CGI-S, respectively. The main side effects were asymptomatic elevated prolactin (n = 12) and excessive weight gain (n = 2). Conclusions: ASD core symptoms and comorbid behaviors in young children improved following chronic treatment with antipsychotic medications, either with or without medications for attention deficit hyperactivity disorder, when combined with standard supportive therapies. Double-blind, placebo-controlled clinical trials are needed to verify these findings.
Relationship of Different Anthropometric Indices with Vascular Ageing in an Adult Population without Cardiovascular Disease—EVA Study

The objectives of this study were to analyse the capacity of different anthropometric indices to predict vascular ageing and this association in Spanish adult population without cardiovascular disease. A total of 501 individuals without cardiovascular disease residing in the capital of Salamanca (Spain) were selected (mean age: 55.9 years, 50.3% women), through stratified random sampling by age and sex. Starting from anthropometric measurements such as weight, height, and waist circumference, hip circumference, or biochemical parameters, we could estimate different indices that reflected general obesity, abdominal obesity, and body fat distribution. Arterial stiffness was evaluated by measuring carotid-femoral pulse wave velocity (cf-PWV) using a SphygmoCor® device. Vascular ageing was defined in three steps: Step 1: the participants with vascular injury were classified as early vascular ageing (EVA); Step 2: classification of the participants using the 10 and 90 percentiles of cf-PWV in the study population by age and sex in EVA, healthy vascular ageing (HVA) and normal vascular ageing (NVA); Step 3: re-classification of participants with arterial hypertension or type 2 diabetes mellitus included in HVA as NVA. The total prevalence of HVA and EVA was 8.4% and 21.4%, respectively. All the analysed anthropometric indices, except waist/hip ratio (WHpR), were associated with vascular ageing. Thus, as the values of the different anthropometric indices increase, the probability of being classified with NVA and as EVA increases. The capacity of the anthropometric indices to identify people with HVA showed values of area under the curve (AUC) ≥ 0.60. The capacity to identify people with EVA, in total, showed values of AUC between 0.55 and 0.60. In conclusion, as the values of the anthropometric indices increased, the probability that the subjects presented EVA increased. However, the relationship of the new anthropometric indices with vascular ageing was not stronger than that of traditional parameters. Therefore, BMI and WC can be considered to be the most useful indices in clinical practice to identify people with vascular ageing in the general population.
Inarticulate past: similarity properties of the ice–climate system and their implications for paleo-record attribution

Abstract. Reconstruction and explanation of past climate evolution using proxy records is the essence of paleoclimatology. In this study, we use dimensional analysis of a dynamical model on orbital timescales to recognize theoretical limits of such forensic inquiries. Specifically, we demonstrate that major past events could have been produced by physically unsimilar processes making the task of paleo-record attribution to a particular phenomenon fundamentally difficult if not impossible. It also means that any future scenario may not have a unique cause and, in this sense, the orbital timescale future may be to some extent less sensitive to specific terrestrial circumstances.
Characterization of totally geodesic foliations with integrable and parallelizable normal bundle

Abstract In this work, we study foliations of arbitrary codimension $\mathfrak{F}$ with integrable normal bundles on complete Riemannian manifolds. We obtain a necessary and sufficient condition for $\mathfrak{F}$ to be totally geodesic. For this, we introduce a special number $\mathfrak{G}_{\mathfrak{F}}^{\alpha}$ that measures when the foliation ceases to be totally geodesic. Furthermore, applying some maximum principle we deduce geometric properties for $\mathfrak{F}$ . We conclude with a geometrical version of Novikov’s theorem (Trans. Moscow Math. Soc. (1965), 268–304), for Riemannian compact manifolds of arbitrary dimension.
Narrow lpa1 Metaxylems Enhance Drought Tolerance and Optimize Water Use for Grain Filling in Dwarf Rice

Rice cultivation needs extensive amounts of water. Moreover, increased frequency of droughts and water scarcity has become a global concern for rice cultivation. Hence, optimization of water use is crucial for sustainable agriculture. Here, we characterized Loose Plant Architecture 1 (LPA1) in vasculature development, water transport, drought resistance, and grain yield. We performed genetic combination of lpa1 with semi-dwarf mutant to offer the optimum rice architecture for more efficient water use. LPA1 expressed in pre-vascular cells of leaf primordia regulates genes associated with carbohydrate metabolism and cell enlargement. Thus, it plays a role in metaxylem enlargement of the aerial organs. Narrow metaxylem of lpa1 exhibit leaves curling on sunny day and convey drought tolerance but reduce grain yield in mature plants. However, the genetic combination of lpa1 with semi-dwarf mutant (dep1-ko or d2) offer optimal water supply and drought resistance without impacting grain-filling rates. Our results show that water use, and transports can be genetically controlled by optimizing metaxylem vessel size and plant height, which may be utilized for enhancing drought tolerance and offers the potential solution to face the more frequent harsh climate condition in the future.
Miestų gamtinės ekosistemos kultūrinės paslaugos ir jų vertinimo aspektai

Straipsnyje aptariama gamtinės ekosistemos paslaugų klasifikacija, išskiriant kultūrines paslaugas ir jų svarbą miesto gyventojams bei bendruomenėms. Remiantis aktualiais moksliniais tyrimais nagrinėjami gamtinės ekosistemos miestuose teikiamų kultūrinių paslaugų vertinimo metodai bei piniginio ir nepiniginio vertinimo aspektai. Keturiuose Lietuvos miestuose atliktas empirinis tyrimas parodė skirtingų tyrimo metodų derinimo galimybes vertinant gamtinės ekosistemos kultūrines paslaugas.
Egyetemi vállalkozás – Lehetőség az egyetemi karrier előmozdítására Közép-Európában?= Academic entrepreneurship – An academic career advancement opportunity in Central Europe?

Az USA erősen versengő, relative bőkezűen es valtozatosan finanszirozott kutatasi rendszereben, ahol a tudosok nagyfoku mobilitasa jellemző, szinte teljesen termeszetes, hogy egy kutato az egyetemi kutatasi eredmenyeinek hasznositasabol szarmazo tudomanyos es uzleti előnyoket spin-off ceg letrehozasaval aknazza ki. A rendszer sajatossagaibol fakadoan az ehhez szukseges kepessegek zomenek mar birtokaban vannak a kutatok, hiszen laboratoriumuk műkodtetese is gyakran cegszerű jelleggel tortenik. A vallalkozas es az egyetem kozott letrejovő szinergiak nemcsak uzleti szempontbol jelentősek, legalabb ennyire fontos az akademiai motivaciok jelenlete, mint peldaul potlolagos finanszirozasi forrasok biztositasa az egyetemi labor szamara, a tehetseges hallgatok egyetem kozeleben tartasa, a talalmany gyakorlati hasznanak demonstracioja, amelyek a kutato egyetemi karrierjet is előmozdithatjak. Tanulmanyunk celja annak vizsgalata, hogy az akademiai motivaciok altal vezerelt, Etzkowitz altal leirt egyetemi vallalkozok csak az USA kutatasi rendszereben lelhetők-e fel, vagy a cegalapitas altal tortenő egyetemi előrelepes mas intezmenyi kornyezetekben is realis lehetőseg-e. A vizsgalat alapjaul a kontinentalis europai es szovjet tudomanyszervezesi gyokerekkel rendelkező magyar egyetemi rendszert valasztottuk, amely torteneti fejlődeseből fakadoan latszolag igen kedvezőtlen korulmenyeket biztosit a „klasszikus” egyetemi vallalkozo kibontakozasahoz. Ugy talaltuk, hogy a „klasszikus” egyetemi vallalkozo meg ezen intezmenyi kozegben is előfordul, azonban egyes tenyezők hatasara elterő fejlődesi palyak is kialakulhatnak.
Molecular Dynamics Simulation of Heat Transport in Silicon Fin Structures

A series of molecular dynamics (MD) simulations has been conducted to investigate the transport process of heat from a heat source consisting only longitudinal optical (LO) phonon in Bulk and SOI Fin structures. The calculation results show that the heat transport from the Fin to the Si substrate is delayed when the buried oxide (BOX) layer exists even if the thickness is only one atomic layer. The kinetic energy distributions of LO and longitudinal acoustic (LA) phonons in SOI Fin structures are extracted from the MD simulations, and the result suggests that the heat transport process is impeded since acoustic phonon stays near the SiO2/Si interface. That is, the retarded heat is an unavoidable in a SOI Fin, a nanowire, or any channel structure confined in an insulating material. Having a heat duct in a device can be effective to avoid the self-heating problem for advanced transistor structures. Keywords-component; self-heating effect, phonons, Fin stuructures, nanowires, SOI, molecular dynamics simulations
"Double Agents": Assessing the Role of Electronic Product Recommendation Systems

Electronic information can easily overwhelm people. Software tools have been introduced to assist humans in filtering and organizing information into more digestible amounts and formats. Many of these tools are altruistic in the sense that they have no vested interest in what the user does with the information. However, some are designed not only to assist buyers but also to steer them in a particular direction. This makes them double agents. Examples of such decision aids exist at a number of vendor sites and include Amazon.com's Your Store, GMs Auto Choice Advisor and IBMs Solution Profiler. This article reviews the research on electronic recommendation agents. It focuses on tools that provide online shoppers with personalized product recommendations and explores the benefits and potential difficulties consumers may experience when using such tools. The article concludes that having a consumer-centric double-agent perspective can lead to a deeper and more comprehensive understanding of the interaction between electronic product-recommendation agents and consumers. This, in turn, can spur the design of better and more effective recommendation tools that allow consumers to speed up their decision processes and improve the quality of the choices they make.
REPUTATION BASED ZONE TRUST DETECTION AND SWATT REVOCATION METHOD USING SPRT IN SENSOR NETWORKS

Wireless sensor networks can be used in several real world applications, including various critical applications such as military surveillance, infrastructure security monitoring and fault detection. Typically sensors are deployed in large number in environments that may not be safe or easily accessible to humans. An adversary or attacker can modify the sensor nodes that operate in the harsh environment and thus can insert faulty data to mislead the whole network. Hence in order to reduce the damage occurred to the compromised sensor nodes, it is extremely important to detect and revoke them as early as possible. The main idea is to propose zone based node compromise detection and revocation scheme for sensor networks. This is achieved using reputation based trust management scheme and software based attestation technique. Software attestation technique has been proposed to verify the integrity of the code without physical access. Whereas Reputation-based Framework for Sensor Networks maintain reputation for other nodes. This reputation is used to evaluate the trustworthiness of other nodes, which in turn establishes a web of trust in the network, which is then used as an inherent aspect in predicting the future behaviour of nodes in the network. Thus the proposed scheme provides effective and robust compromised sensor node detection and revocation capability with little overhead.
Two- and three-dimensional deep human detection by generating orthographic top view image from dense point cloud

Abstract. Human detection still suffers from occlusion, complex backgrounds, and scale-variant problems. Projecting three-dimensional (3D) points onto the ground to generate an orthographic top view (OTV) image for detection can effectively alleviate these problems. However, depth sensors may be placed arbitrarily, making it difficult to create OTV images by the dense point cloud converted from a depth image. We focus on the generation of OTV images and human detection via the constructed OTV image. First, we propose a ground plane extraction method that is well suitable for various camera positions and orientations in complex scenes. Next, points are converted to a uniform coordinate system by ground parameters and encoded to generate a three-channel OTV image. Then, the mainstream two-dimensional (2D) network is employed to detect the human directly on OTV images and further obtain the 3D bounding box by computing the mapping from the OTV image. Besides, we propose a semiautomated annotation method to solve the problem of few OTV image annotations. The proposed method is evaluated on the EPFL dataset, including two subsets, and achieves state-of-the-art performance compared with the existing approaches. Moreover, our 2D and 3D human detection method can run more than 26FPS on the CPU.
Production, Bioprocessing and Anti-Proliferative Activity of Camptothecin from Penicillium chrysogenum, “An Endozoic of Marine Sponge, Cliona sp.”, as a Metabolically Stable Camptothecin Producing Isolate

Exploring the metabolic potency of fungi as camptothecin producers raises the hope of their usage as an industrial source of camptothecin, due to their short-life span and the feasibility of metabolic engineering. However, the tiny yield and loss of camptothecin productivity of fungi during storage and sub-culturing are challenges that counteract this approach. Marine fungi could be a novel source for camptothecin production, with higher yield and reliable metabolic sustainability. The marine fungal isolate Penicillium chrysogenum EFBL # OL597937.1 derived from the sponge “Cliona sp. ” has been morphologically identified and molecularly confirmed, based on the Internal Transcribed Spacer sequence, exhibiting the highest yield of camptothecin (110 μg/L). The molecular structure and chemical identity of P. chrysogenum derived camptothecin has been resolved by HPLC, FTIR and LC-MS/MS analyses, giving the same spectroscopic profiles and mass fragmentation patterns as authentic camptothecin. The extracted camptothecin displayed a strong anti-proliferative activity towards HEP-2 and HCT-116 (IC50 values 0.33–0.35 µM). The yield of camptothecin was maximized by nutritional optimization of P. chrysogenum with a Plackett-Burman design, and the productivity of camptothecin increased by 1.8 fold (200 µg/L), compared to control fungal cultures. Upon storage at 4 °C as slope culture for 8 months, the productivity of camptothecin for P. chrysogenum was reduced by 40% compared to the initial culture. Visual fading of the mycelial pigmentation of P. chrysogenum was observed during fungal storage, matched with loss of camptothecin productivity. Methylene chloride extracts of Cliona sp. had the potency to completely restore the camptothecin productivity of P. chrysogenum, ensuring the partial dependence of the expression of the camptothecin biosynthetic machinery of P. chrysogenum on the chemical signals derived from the sponge, or the associated microbial flora. This is the first report describing the feasibility of P. chrysogenum, endozoic of Cliona sp. , for camptothecin production, along with reliable metabolic biosynthetic stability, which could be a new platform for scaling-up camptothecin production.
KESEHATAN AMBING DAN HIGIENE PEMERAHAN DI PETERNAKAN SAPI PERAH DESA PASIR BUNCIR KECAMATAN CARINGIN

Penelitian ini bertujuan untuk mengetahui kesehatan ambing sapi-sapi perah di Desa Pasir Buncir Kecamatan Caringin dan mengetahui higiene pemerahan yang dilakukan oleh pemerah di peternakan. Hasil analisis yang dilakukan pada sampel yang diambil dari peternakan rakyat tersebut diketahui bahwa rata-rata jumlah sel somatik dari susu yang langsung diperah dari keempat kwartir ambing adalah 7,0 x 104 sel/ml dengan rata- rata jumlah mikroba 6,8 x 104 bakteri/ml. Ditemukan S. aureus dan koliform dalam sampel susu yang langsung diperah dari puting (3,2 x 103 CFU/ml; 4,4 x 102 CFU/ml), susu yang sudah ditampung dalam ember perah (4,2 x 103 CFU/ml; 2,8 x 105 CFU/ml), tangan pemerah (1,4 x 10 CFU/ml; 3,7 x 104 CFU/ml); air (1,0 x 102 CFU/ml; 4,9 x 102 CFU/ml), dan ember perah (1,0 x 10 CFU/ml; 1,1 x 104 CFU/ml). E. coli tidak ditemukan dalam seluruh sampel yang diteliti.
BER performance analysis of asynchronous NOMA with arbitrary phase offset

An asynchronous transmission scenario for non-orthogonal multiple access (NOMA) user signals with arbitrary phase offset is investigated in this paper. To improve the system performance in the user power-balanced conditions, we adopt a synthetic detection method at the receiver, i.e., the jointly optimal maximal likelihood detection aided triangular successive interference cancellation (JO ML-TSIC) method. Analytical bit error rate (BER) solutions are obtained for a two-user case with the optimal, intentional one-half symbol period time delay implemented between the user signals. Furthermore, closed-form BER solutions for the case using the triangular successive interference cancellation (TSIC) detection method are also derived for comparisons. Numerical results show that the JO ML-TSIC receiver for the asynchronous system outperforms the TSIC receiver as well as the synchronous successive interference cancellation (SIC) receiver in all the conditions concerned. The results also show that the superiority of the JO ML-TSIC receiver is strengthened when the signals experience flat Rayleigh fading channels compared to the TSIC and the synchronous SIC receivers.
Modelling, Design and Simulation of a Quadrotor with Tilting Rotors Actuated by a Memory Shape Wire.

Resumo: This paper deals with a quad rotor hovercraft provided with a mechanism based on a memory shape alloy witch allows tilting the rotors angles. Thus the thrust force vector of each propeller can assume two possible directions: perpendicular to the plane formed by the center of the rotors or tilted inwards. The performed analysis shows that with the second set the vehicle has greater stability, while with the first, there is higher agility. The vehicle’s dynamics was studied both analytically and by simulations using MATLAB/Simulink in order to compare the two possible configurations. Based on the analytical study, it is shown that the internal inclination of the rotors, combined with the placement of the vehicle’s center of mass below the propellers plane, allows an increase on the maximum torque applied by the controller to establish attitude. Three different scenarios were performed by simulation. In the first scenario, an initial attitude inclination was applied to the hovering Micro Aerial Vehicle (MAV) and the time until stabilization was measured. In the second scenario, with the MAV hovering, it was measured the time it takes to move vertically up to a certain altitude. The MAV with tilted rotors showed better results in the first scenario, wile the conventional configuration showed better performance in the second scenario. The third simulation revealed that the act of tilting the rotors does not change the MAV’s position significantly. Palavras-chave: Quad Rotor Hovercraft, Dynamic Model, Memory Shape alloy, Aerial Robotics
Research on the sensing performance calibration of omni-directional broadband interdigital transducer based on PVDF substrate

Structural health monitoring (SHM) is of vital importance to the detection of damage in large structures. Ultrasonic transducers used to excite and receive signals have become an important part of SHM. For the traditional PZT ultrasonic transducer, there are some shortcomings such as poor flexibility and designability. Due to the limitation of structure shape, the rectangular interdigital transducers, which are widely used in structural health monitoring, have difficulty in receiving signals in all directions and the frequency bandwidth is narrow and the detection efficiency is low. On this basis, it is proposed to use the flexible piezoelectric material PVDF as the substrate. Combined with the dispersion theory of aluminium plate and the design principle of IDT, an omni-directional flexible annular PVDF Interdigital Transducer (PVDF-IDT) is designed. The device is produced by 3D printing technology. The sensitivity, frequency response, orientation and other performances of the flexible annular PVDF-IDT are calibrated, which lays the foundation for its application in structural inspection.
Recent Development in Antioxidant Peptides of Woody Oil Plant By-Products

ABSTRACT As a critical and prevalent source of functional edible oils, woody oil plants with by-products that contain numerous accessible nutrients are widely farmed around the world. Researches on the peptide from plants have attracted the scientists’ interest in recent years. Novel antioxidant peptides from woody oil plant by-products were discovered, and the antioxidant properties in vitro, in vivo and in silico have been conducted. The species origin, manufacturing and purification processes, biological function researches of antioxidant peptides of woody oil plant by-products were described and refined in this review, which also demonstrated a potential mechanism combining antioxidant peptide intrinsic characteristics and activity screening. Moreover, this paper revealed their prospective role in the fields of medicinal agents, nutraceuticals and cosmetics.