Miracle-dz/UniFAR-FTUs huggingface dataset:
Fucoidan Protects against Doxorubicin-Induced Cardiotoxicity by Reducing Oxidative Stress and Preventing Mitochondrial Function Injury

Doxorubicin (DOXO) is a potent chemotherapeutic drug widely used to treat various cancers. However, its clinical application is limited due to serious adverse effects on dose-dependent cardiotoxicity. Although the underlying mechanism has not been fully clarified, DOXO-induced cardiotoxicity has been mainly attributed to the accumulation of reactive oxygen species (ROS) in cardiomyocytes. Fucoidan, as a kind of sulphated polysaccharide existing in numerous brown seaweed, has potent anti-oxidant, immune-regulatory, anti-tumor, anti-coagulate and anti-viral activities. Here, we explore the potential protective role and mechanism of fucoidan in DOXO-induced cardiotoxicity in mice. Our results show that oral fucoidan supplement exerts potent protective effects against DOXO-induced cardiotoxicity by reducing oxidative stress and preventing mitochondrial function injury. The improved effect of fucoidan on DOXO-induced cardiotoxicity was evaluated by echocardiography, cardiac myocytes size and cardiac fibrosis analysis, and the expression of genes related to cardiac dysfunction and remodeling. Fucoidan reduced the ROS content and the MDA levels but enhanced the activity of antioxidant enzymes GSH-PX and SOD in the mouse serum in a DOXO-induced cardiotoxicity model. In addition, fucoidan also increased the ATP production capacity and restored the levels of a mitochondrial respiratory chain complex in heart tissue. Collectively, this study highlights fucoidan as a potential polysaccharide for protecting against DOXO-induced cardiovascular diseases.
The Convergence of Chinese and Portuguese Architectural Styles in the Context of Macau World Heritage

: The "Historic Centre of Macau" Successfully inscribed on the World Heritage List for its rich architectural types and well-preserved building forms, the historical buildings in the Macao World Heritage Site vary in style, and the unique urban imagery of Chinese buildings, Portuguese houses, and buildings of intermingled Chinese and Portuguese styles are analyzed for their historical background and stylistic characteristics, which are conducive to the conservation of Macao's architectural heritage and can clearly demonstrate the record of the complementary and diverse coexistence of Chinese and Portuguese cultural exchanges for over 400 years.
A Comparison of Discourse Scaffolding between Novice and Expert English Teachers in Senior High Schools from the Perspective of Social Culture Theory

: Guided by Vygotsky's social culture theory, this paper makes a comparative analysis of six types of scaffolding used by novice and expert English senior high teachers, taking classroom discourse of novice and expert English senior high teachers as the research corpus, to summarize and find some problems of discourse scaffolding that teachers have encountered in teaching, then put forward corresponding improvement suggestions.
Competition and distress in banks in India: An application of panel data

Abstract Financial distress (FD) is a crucial issue that needs to be resolved in time; otherwise, it may adversely influence society’s areas. Therefore, identifying the factors responsible for FD and how these factors affect FD is an exciting area of research. Given this, this paper proposes investigating the effect of competition on the bank’s FD in India. This paper uses the data of 34 banks operating in India for the observation period (2016–2019). Three variants of Altman’s Z-score are used for the assessment of FD. Lerner’s index of the banks is developed for the competition measurement. A panel data analysis is further performed for regression analysis. The current study has an interesting outcome. The findings reveal that high market power or low competition lowers financial distress and adds more financial stability in banks in India. This paper provides fresh evidence on the connection between market power and FD of banks in India. Moreover, no other study has been observed to use all the three variants of Altman’s z-score to provide robustness and reliability in results. Therefore, the study has a significant contribution and a novelty in its approach.
Intensive Reading and Task- Based Approaches: A Relevant Viewpoint in Improving Students’ Reading and Writing Proficiency

The gap that exists between reading and writing proficiency in English continues to grow. Moreover, the poor performance of the students is alarming when it comes to reading and writing. The kind of approach, strategy, and method has a big impact and factor which would affect the students’ performance. The purpose of this study is to determine the significant difference of Intensive reading approach in reading proficiency in terms of word recognition, comprehension, and speed. Also, to determine the significant difference of Task- based approach in the writing proficiency of the students in terms of sentence structure, vocabulary, cohesion, and transition device. Consequently, the intensive reading approach with the components of Know, want, and learn (KWL) Chart, Vocabulary Self Selection strategy (VSS), and Story maps used during the execution of the lessons. However, in the task – based approach which has the components of Listing, Ordering/sorting, Comparing/contrasting was used as part of the writing test. The findings show that there was significant difference in intensive reading approach in the reading proficiency of the respondents in terms of word recognition and comprehension. There were constant changes every time the treatment was being used. However, in speed, the changes were being manifested. It implies that the longer the time you use the treatment, the higher the chance that the speed of the students will be improved. The length of time of the intervention was another factor that may have caused these non-significant results. In the same manner, there was significant difference in task- based approach in the writing proficiency of the respondents in terms of sentence structure, vocabulary, cohesion, and transitional devices. The writing proficiency was all improved across the three post tests using the intervention. The findings show that there was improvement in the three consecutive posttests of Grade 8 respondents in reading and writing proficiency after the exposure to the intensive reading and task-based approaches. The use of the said approaches shows positive results in enhancing reading proficiency in terms of word recognition, comprehension, and speed. Moreso, in writing proficiency in terms of sentence structure, vocabulary, cohesion, and transitional devices. Keywords: Intensive Reading Approach, Task- based Approach, Reading Proficiency, Writing Proficiency.
Structural assessment and expected utility gain

This paper contains an introduction, probabilistic formulation, and exemplification (1) of system state and utility actions, (2) system state and utility action value analysis and (3) a threshold formulation for a predicted information and action decision analysis. The approaches build upon structural condition assessment and provide a basis for the condition management by maximising the expected utility for information and actions before information acquirement and action implementation. Following the basic distinction of system state and utility actions, strengthening, replacement, repair, load reduction and consequence reduction actions are formulated. With an exemplary study encompassing an expected utility calculation and an action value analysis, it is demonstrated how expected utility optimal physical system changes can be identified before implementation. The threshold formulation for a predicted information and action decision analysis relies on the equality of the decision theoretical posterior action optimality condition. By extending the exemplary predicted action decision analyses with different structural health information (SHI), the threshold formulation is exemplified and the optimal condition management strategies are identified.
A high-performance porous flexible composite film sensor for tension monitoring

Flexible, lightweight sensors with a wide strain-sensing range are showing increasing significance in structural health monitoring compared with conventional hard sensors, which typically have a small strain range, are heavyweight, and have a large volume. In this work, salt particle precipitation and mechanical coating methods are used to fabricate porous graphene nanoplatelet (GNP)/polydimethylsiloxane (PDMS) flexible sensors for tension monitoring in structural health applications. The signal transformation through the Back Propagation (BP) algorithm is integrated to provide monitoring data that are comparable with other sensors. The results reveal that the flexible sensors with a low content of GNPs (0.1–0.25 wt%) possess better flexibility, allowing tensile strains over 200% to be measured. In addition, due to the enhanced deformation capacity of the pore structures, they can achieve high sensitivity (1–1000) under 65% strain, and a fast response time (70 ms) under 10% strain at 60 mm min−1. They also show high performance in the fatigue test (20 000 cycles) under 5% strain, and can effectively respond to bending and torsion. In addition, the sensors show an obvious response to temperature. Overall, the prepared flexible composite sensors in this work have the advantages of a wide strain-sensing range, a full-coverage conductive network, and being lightweight, and show potential for structural health monitoring in the near future.
Croissance des fonctions propres du laplacien sur un domaine circulaire

The goal of this master’s thesis is to explore the properties of the solutions of the eigenvalue problem for the Laplace operator ∆ on a disk as the eigenvalues λ go to infinity. More specifically, we study the growth rate of the pointwise and the L∞ norms of the eigenfunctions. Let D be the unit disk and ∂D be its boundary (the unit circle). We study the solutions of the eigenvalue problem ∆f = λf with either Dirichlet boundary condition (f |∂D = 0) or Neumann boundary condition ( ∂n |∂D = 0; note that for the disk the normal derivative is simply the derivative with respect to the radial variable: ∂ ∂n = ∂ ∂r ). The corresponding eigenfunctions are given by: fλ(r, θ) = fn,m(r, θ) = Jn(kn,mr)(A cos(nθ) +B sin(nθ)) (Dirichlet) f λ (r, θ) = f N n,m(r, θ) = Jn(k ′ n,mr)(A cos(nθ) +B sin(nθ)) (Neumann) where Jn is the n order Bessel function of the first type, kn,m is its m zero and k′ n,m is the m th zero of its derivative (here we denote the eigenfunctions for the Dirichlet problem by f and those for the Neumann problem by f ). The spectrum of the Laplacian on D, SpD(∆), that is the set of its eigenvalues, is given by: SpD(∆) = {λ : ∆f = λf} = {k n,m : n = 0, 1, 2, . m = 1, 2, . } (Dirichlet) SpD(∆) = {λ : ∆f = λf} = {k′ n,m : n = 0, 1, 2, . m = 1, 2, . } (Neumann) Finally, we normalize theL norm of the eigenfunctions onD, namely: ∫ D F 2 λ da = 1 (here and further on we use the notation Fλ for the normalized eigenfunctions and fλ for arbitrary eigenfunctions). Under these conditions, we study the growth rate of the L∞ norm of the normalized eigenfunctions, ||Fλ||∞, in relation to λ. It is important to mention that the L∞ norm of a function on a given domain corresponds to the maximum of its absolute value on the domain. Note that λ depends on two parameters, m and n, and the relation between λ and the L∞ norm depends on the regime at which m
Data Analysis on Hushen 300 Index

: Research purposes: to study the correlation between Hushen 300 index and its lagged index. The specific methods is as follows: establishing the auto-regressive model (AR (P)). And the conclusion is that the model results show that the index of four days and six days ago are of great reference for the prediction of Hushen 300 index on that day. There was a positive correlation between the four days ago and that day in terms of Hushen 300 index, and on the contrary, there is a negative correlation between six days ago and the same day of Hushen 300 index.
The Impact of Thyme, Rosemary and Basil Extracts on the Chemical, Sensory and Microbiological Quality of Vacuumed Packed Mackerel Balls

The effect of natural extracts (0.05%) and vacuum packaging on the sensory, chemical, and microbiological quality of mackerel balls were evaluated at refrigerated (4 ± 2 °C) storage. Natural extracts thyme (38.13 mg GAE/g), rosemary (81.85 mg GAE/g) and basil (21.08 mg GAE/g) were evaluated. Natural extracts imparted stability to lipids (TBA, FFA, and PV), and the ability was further improved by vacuum packaging. Biochemical changes (TVB-N, pH) and microbiological quality (total viable count) were also retained. Control samples packed under vacuum were found to cross over acceptable limits on day 28. Based on sensory quality evaluation, samples treated with rosemary and thyme extracts showed superior sensory quality over control, whilebasil-treated samples were not found acceptable at day 28. Consequently, the inclusion of thyme and rosemary extracts exhibits preservative quality when combined with vacuum packaging, retaining biochemical, microbial, and sensory quality.
Impact of Catheter Ablation on Long-Term Outcomes in Patients With Atrial Fibrillation: A Meta-Analysis

The role of catheter ablation in patients with atrial fibrillation (AF) in enhancing long-term outcomes remains unknown. This meta-analysis aimed to assess the impact of catheter ablation on stroke, all-cause mortality, hospitalization due to heart failure, and major bleeding events in patients with atrial fibrillation. This meta-analysis was conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The data search was carried out by two authors independently using online databases including PubMed, EMBASE, and Cochrane library. The primary outcome was a stroke. The secondary outcomes were all-cause mortality, hospitalization for heart failure, and major bleeding events. Total, 10 articles were included in the current meta-analysis encompassing 275392 patients (33291 in the ablation group and 244974 in the non-ablation group). Among all included studies, one study was a randomized control trial, while the remaining other were retrospective cohorts. The current meta-analysis showed that catheter-based AF ablation reduced the risk of stroke (hazard ratio {HR}: 0.61, 95% CI: 0.49-0.77), all-cause mortality (HR: 0.60, 95% CI: 0.51-0.71), and hospitalization for heart failure (HR: 0.57, 95% CI: 0.43-0.76). No significant differences were reported in terms of major bleeding events between patients who received catheter-based AF ablation and patients who did not receive catheter-based AF ablation (HR: 0.96, 95% CI: 0.80-1.14). In the current meta-analysis, catheter-based AF ablation was associated with decreased risk of all-cause mortality, stroke, and hospitalization due to heart failure. However, no significant difference was reported in terms of major bleeding events.
Sur l'estimation séquentielle d'un quantile d'une courbe dose-réponse

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The Effect of Continuing Chemotherapy after Chemoradiotherapy during the Time to Surgery on Tumor Response and Survival for Local Advanced Rectal Cancer

Aim The current standard treatment of locally advanced rectal carcinoma is total mesorectal excision and postoperative adjuvant chemotherapy after neoadjuvant concurrent chemoradiotherapy (NCRT). Many studies have shown that pathological complete response (pCR) is an important prognostic factor for patients receiving NCRT. Many studies have therefore been conducted to increase pCR rates by changing the perioperative treatment strategies. Prolonging the chemotherapy time may be a reasonable way to increase the effectiveness of NCRT, pCR, and survival rates. We investigated whether neoadjuvant consolidation chemotherapy had an effect on tumor response and survival. Methods The data of 163 patients diagnosed with locally advanced rectal carcinoma were evaluated. The data of 107 patients (Group 1) who were radiologically T3–T4 and/or N+ and received chemotherapy after NCRT until their operations were compared with the data of 56 patients (Group 2) who were operated after NCRT. Results Group 1 patients had tumor and node downstaging. Their pCR was found significantly higher than in Group 2 (p = 0.005). In Group 1 patients with T3, pCR was significantly higher than for those with T4. The elapsed time between NCRT and surgery was significantly longer in patients with pCR (respectively, p = 0.012 and p = 0.008). Conclusion Neoadjuvant consolidation chemotherapy after NCRT is a safe approach that can lead to higher pathological complete response rates. The time until surgery with neoadjuvant consolidation chemotherapy may provide the chance to follow the patient without surgery in addition to increasing pCR.
Research on Wind Speed Prediction Model Based on WOA-LSTM

: To tackle the issues of haphazardness of LSTM model boundaries and slow model intermingling speed, work on the exactness of wind speed forecast model, and better work on the security and economy of wind power age frameworks, this paper proposes an improved LSTM based on the Whale Optimization Algorithm (WOA), and conducts simulation analysis based on the US meteorological data. The exploration results show that:1) Through persistent preparation to track down reasonable hyperparameters and confirm them, it is observed that the attributes of the WOA calculation can successfully track down the worldwide ideal answer for upgrade the boundaries of the LSTM model; 2) Compared with the traditional LSTM neural network prediction model, the WOA-LSTM reduces the root mean square error (RMSE) and mean absolute error (MAE) by 0.43035 and 0.23115, respectively, and improves the goodness of fit ( 𝑅 2 ) by 0.03763. It shows that the model has better accuracy and stability for wind speed prediction.
Assessment of the Nutritional Quality of Plant Lipids Using Atherogenicity and Thrombogenicity Indices

Dietary lipids derived from plants have different compositions of individual fatty acids (FA), providing different physical and chemical properties with positive or adverse health effects on humans. To evaluate the nutritional value and assess the FA composition of various plants, the atherogenicity (AI) and thrombogenicity (TI) indices were calculated and reviewed for nine different categories of fats and oils. This included common oils, unconventional oils, nut oils originating from temperate regions, Amazonian and tropical fats and oils, chia seed oil, traditional nuts originating from temperate regions, unconventional nuts, seeds, and fruits, and their products. The main factors influencing fatty acid composition in plants are growth location, genotype, and environmental variation, particularly temperature after flowering, humidity, and frequency of rainfall (exceeding cultivar variation). The lowest AI was calculated for rapeseed oil (0.05), whereas the highest value was obtained for tucuman seeds (16.29). Chia seed oil had the lowest TI (0.04), and murumuru butter had the highest (6.69). The differences in FA composition and subsequent changes in the lipid health indices of the investigated fats and oils indicate their importance in the human diet.
COVID-19 Vaccinating Russian Medical Students—Challenges and Solutions: A Cross-Sectional Study

Background: The role of preventive measures increases significantly in the absence of effective specific COVID-19 treatment. Mass population immunization and the achievement of collective immunity are of particular importance. The future development of public attitudes towards SARS-CoV-2 immunization depends significantly on medical students, as future physicians. Therefore, it seemed relevant to determine the percentage of COVID-19-vaccinated medical students and to identify the factors significantly affecting this indicator. Methods: A total of 2890 medical students from years one to six, studying at nine leading Russian medical universities, participated in an anonymous sociological survey. The study was performed in accordance with the STROBE guidelines. Results: It was found that the percentage of vaccinated Russian medical students at the beginning of the academic year 2021 was 58.8 ± 7.69%, which did not significantly differ from the vaccination coverage of the general population in the corresponding regions (54.19 ± 4.83%). Student vaccination rate was largely determined by the region-specific epidemiological situation. The level of student vaccination coverage did not depend on the gender or student residence (in a family or in a university dormitory). The group of senior students had a higher number of COVID-19 vaccine completers than the group of junior students. The lack of reliable information about COVID-19 vaccines had a pronounced negative impact on the SARS-CoV-2 immunization process. Significant information sources influencing student attitudes toward vaccination included medical professionals, medical universities, academic conferences, and manuscripts, which at that time provided the least information. Conclusion: The obtained results make it possible to develop recommendations to promote SARS-CoV-2 immunoprophylaxis among students and the general population and to increase collective immunity.
Research on Forest Management in the Context of Carbon Sequestration

: As resources are exploited around the world, the environment is being affected as never before, and one of the more serious problems is global warming. This paper presents a more comprehensive study of forest management plans in areas such as the Cariboo Forest. First, the paper fit the relationship between tree age and volume using logistic regression, and then estimate the forest's maximum carbon storage 𝐶𝑠𝑢𝑚 using the biomass conversion factor method along with a modified Leslie model. In this paper, three aspects of economic benefit, social demand and carbon storage are balanced, and a forest decision-making model based on multi-objective linear programming is established. This paper applies the model to the Cariboo Forest area and optimizes the carbon sequestration assessment model using the first-order decay method (FOD), taking into account the carbon release from wood products.
A System Literature Review of Personalized e-Learning

: This paper investigates earlier research publications on personalized learning, exceptionally personalized e-learning, appearing in the World of Science Education and Educational Research categories. The researcher initially consults HistCite to identify the range of relevant articles and their citation links. The HistCite technique finds and isolates personalized e-learning studies. In addition, several articles are selected based on criteria and the EPPI guide for in-depth analysis to discover trends, design principles, and future research prospects