Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of isorhamnetin for suppression of electrical and structural remodeling via CaMKII-RyR2 and TRPC-mediated MAPK pathways in atrial ﬁbrillation

Background and Purpose: Isorhamnetin, a natural ﬂavonoid, has strong antioxidant and anti-ﬁbrotic eﬀects, and a regulatory eﬀect against Ca2+-handling. Atrial remodeling due to ﬁbrosis and abnormal intracellular Ca2+ activities contributes to initiation and persistence of atrial ﬁbrillation (AF). This study investigated the eﬀect of isorhamnetin on angiotensin II (AngII)- induced AF in mice. Experimental Approach: Wild-type male mice (C57BL/6J, 8 weeks old) were assigned to three groups: (1) control group, (2) AngII-treated group, and (3) AngII-and isorhamnetin-treated groups. AngII (1000 ng/kg/min) and isorham-netin (5 mg/kg) were administered continuously via an implantable osmotic pump for two weeks and intraperitoneally one week before initiating AngII administration, respectively. AF induction and electrophysiological studies, Ca2+ imaging with isolated atrial myocytes and HL-1 cells, and action potential duration (APD) measurements using HL-1 cells were performed. AF-related molecule expression was assessed and histopathological examination was performed. Key Results: Isorhamnetin decreased AF inducibility compared to the AngII group and restored AngII-induced atrial eﬀective refractory period prolongation. Isorham-netin eliminated abnormal diastolic intracellular Ca2+ activities induced by AngII. Isorhamnetin also abrogated AngII-induced APD prolongation and abnormal Ca2+ loading in HL-1 cells. Furthermore, isorhamnetin strongly attenuated AngII-induced left atrial enlargement and atrial ﬁbrosis. AngII-induced elevated expression of AF-associated molecules, such as ox-CaMKII, p-RyR2, p-JNK, p-ERK, and TRPC3/6, was improved by isorhamnetin treatment. Conclusion and Implications: The ﬁndings of this study suggest that isorhamnetin prevents AngII-induced AF vulnerability and arrhythmogenic atrial remodeling via modulating CaMKII-RyR2 and TRPC-mediated MAPK pathways, highlighting its potential as an anti-arrhythmogenic pharmaceutical or dietary supplement.
Sequence Organization In Interaction A Primer In Conversation Analysis

Thank you very much for reading sequence organization in interaction a primer in conversation analysis. Maybe you have knowledge that, people have look numerous times for their chosen novels like this sequence organization in interaction a primer in conversation analysis, but end up in malicious downloads. Rather than reading a good book with a cup of coffee in the afternoon, instead they juggled with some infectious virus inside their laptop.
High long-term absolute risk of recurrent venous thromboembolism in patients with hereditary deficiencies of protein S, protein C or antithrombin

Summary Hereditary deficiencies of protein S, protein C and antithrombin are known risk factors for first venous thromboembolism. We assessed the absolute risk of recurrence, and the contribution of concomitant thrombophilic defects in a large cohort of families with these deficiencies. Annual incidence of recurrence was estimated in 130 deficient patients, with separate estimates for those with each of protein S, protein C, and antithrombin deficiency, and in eight non-deficient patients with prior venous thromboembolism. All patients were also tested for factor V Leiden, prothrombin G20210A, high levels of factors VIII, IX and XI, and hyperhomocysteinemia. There were 81 recurrent events among 130 deficient patients. Median follow-up was 4.6 years. Annual incidences (95% confidence interval) of recurrent venous thromboembolism were 8.4% (5.8–11.7) for protein S deficiency, 6.0% (3.9–8.7) for protein C deficiency, 10.0% (6.1–15.4) for antithrombin deficiency, and overall 7.7% (6.1–9.5). Relative risk of recurrence in patients with a spontaneous versus provoked first event was 1.5 (0.95–2.3). Cumulative recurrence rates at 1, 5 and 10 years were 15%, 38% and 53%. Relative risk of recurrence with concomitant defects was 1.4 (0.7–2.6) (1 defect) and 1.4 (0.8–2.7) (≥2 defects). Annual incidence was 1.0% (0.03–5.5) in eight non-deficient patients. Annual incidence of major bleeding in deficient patients on oral anticoagulant treatment was 0.5% (0.2–1.0). We conclude that patients with a hereditary protein S, protein C or antithrombin deficiency appear to have a high absolute risk of recurrence. This risk is increased after a first spontaneous event, and by concomitance of other thrombophilic defects.
Redistribution zonale et méridienne de masse aux échelles ENSO et décennale dans le Pacifique tropical

Les deux principaux modes de variabilite interannuelle en niveau de la mer et vent zonal sont mis en evidence a l’aide de donnees satellitaires sur la periode 1993-99 et d’un modele lineaire force par les vents observes sur la periode 1964-99. Le premier mode, caracteristique d’ENSO, consiste en un basculement zonal de niveau de la mer autour de la ligne de changement de date, associe a des anomalies de vent equatorial a la meme longitude. Le second mode consiste en un basculement meridien de niveau de la mer autour de 5°N, associe a des anomalies de vent de signe oppose dans le nord-ouest et le sud-est du Pacifique tropical. Ce second mode, statistiquement precurseur d’ENSO, semble inclure une composante decennale. Il est particulierement actif pendant les forts evenements El Nino de 1982-83 et 1997-98. Les transports (0-200m) associes a ces deux modes sont calcules a l’aide du modele. Le premier mode est essentiellement lie a des transports zonaux. Le second mode, qui s’apparente a une version asymetrique et basse frequence de la theorie de l’oscillateur recharge, fait intervenir principalement le transport geostrophique a 5°N dans le milieu du bassin. Un OGCM, dont le forcage atmospherique est issu de reanalyses, est utilise ensuite sur la periode 1951-99. Il reproduit les modes de variabilite decrits precedemment. Le modele est valide a l’aide de donnees de courants de surface, transports, hauteur dynamique et niveau de la mer. La hauteur dynamique simulee montre une tendance lineaire en partie artificielle. L’origine de cette tendance est identifiee dans le forcage en vent. Les cellules meridiennes de circulation subtropicale, qui joueraient un role important dans la variabilite decennale du Pacifique tropical, sont simulees. Le modele montre, en accord avec certaines donnees, que l’augmentation de la SST equatoriale durant les dernieres decennies pourrait etre liee a la baisse de la convergence des transports dans la pycnocline.
Improvement to Air Management Practices Assessment Tool (AMPAT): Scientific Literature Database

Abstract. The livestock and poultry production industry lacks a current, science-based guide for evaluation of air quality mitigation technologies. Therefore, we performed a science-based review of mitigation technologies using practical, stakeholders-oriented evaluation criteria to identify knowledge gaps/needs and focuses for future research efforts on technologies and areas with the greatest impact potential. Our objectives were to (1) present a recently completed Literature Database, and (2) identify and rank research needs and knowledge gaps based on the Literature Database. The Air Management Practices Tool (AMPAT) is web-based (available at www.agronext.iastate.edu/ampat) and provides an objective overview of mitigation practices best suited to address odor, gaseous, and particulate matter (PM) emissions at livestock operations. This tool helps livestock and poultry producers compare and explore different mitigation technologies. Simultaneously, a literature review of 267 papers was performed to evaluate mitigation technologies performance for emissions of odor, VOCs, NH 3 , H 2 S, PM, and GHGs and inform future research needs. Swine production systems were the most researched with 52% of the data entries. Housing and manure storage were the most researched sources of emissions with 41 and 43% of the data entries respectively. Biofilters were the most popular and farm tested technology for reducing emissions from animal housing. Aeration, anaerobic digestion, composting, diet manipulation and covers were the most researched technologies for reducing emission during manure storage and handling, with aeration being the most effective means of odor reduction farm scale tested. Injection or incorporation was the most farm tested and effective technology researched for land application.
Streetscape Features Related to Pedestrian Activity

By measuring twenty streetscape features and numerous other variables for 588 blocks in New York City, we were able to identify variables that explain pedestrian traffic volumes. We found significant positive correlations between three out of twenty streetscape features with pedestrian counts after controlling for density and other built environmental variables. The significant streetscape features are the proportion of windows on the street, the proportion of active street frontage, and the number of pieces of street furniture. This study provides guidance for streetscape projects that aim to create walkable streets and pedestrian-friendly environments.
Bubonic Plague: a brief history of changes to current situation in Brazil

Plague is a globally distributed, zoonotic disease caused by the bacterium Yersinia pestis. With recurrent epidemics since the Antique, the plague ravaged the population, producing demographic, political, cultural and religious incommensurables effects. The major clinical forms of plague are bubonic, pneumonic, and septic. The signals and symptoms include fever, chills, general malaise, buboes, may evolve to septicemia, meningitis, hemorrhages, disseminate intravascular coagulation, shock and, not rarely, death. It can occur, still, lung infection (pneumonic form of the disease), with severe respiratory condition, fever, dyspnea, also leading to death.
A monthly 1 ◦ resolution dataset of daytime cloud fraction over the Arctic during 2000–2020 based on multiple satellite products

The low accuracy of satellite cloud fraction (CF) data over the Arctic seriously restricts the accurate assessment of the regional and global radiative energy balance under a changing climate. Previous studies have reported that no individual satellite CF product could satisfy the needs of accuracy and spatiotemporal coverage simultaneously for long-term applications over the Arctic. Merging multiple CF products with complementary properties can provide an effective way to produce a spatiotemporally complete CF data record with higher accuracy. This study proposed a spatiotemporal statistical data fusion framework based on cumulative distribution function (CDF) matching and the Bayesian maximum entropy (BME) method to produce a synthetic 1 ◦ × 1 ◦ CF dataset in the
Analisis Simulasi Power System Stabilizers (PSS) pada Single Machine Damping System

Untuk menyuplai kebutuhan energi listrik dibutuhkan kemampuan pada sistem pembangkit yang dapat dihandalkan, hal ini berpengaruh pada kualitas daya listrik yang disalurkan kepada konsumen tersebut. Untuk memperoleh daya listrik yang berkualitas dibutuhkan pengaturan sistem pada sisi pembangkit yang efektif dan efisien. Maka dari itu perlu dilakukan pengaturan desain pada pembangkit yang dalam hal ini generator pembangkit sehingga didapatkan generator yang benar-benar baik dan dapat dihandalkan kualitasnya. Untuk mendapatkan hasil terbaik, maka dilakukan simulasi pada sisi generator sebagai wujud perkembangan teknologi yang pada akhirnya dengan memanfaatkan perkembangan teknologi pada sistem tenaga listrik akan lebih mudah dalam mendesain dan memperoleh hasil sesuai dengan yang diinginkan.
Benefits of Membership

Explaining the multitudinous forms of social aggregation across animal taxa is a major challenge in evolutionary biology. In their Viewpoint “Complexity, pattern, and evolutionary trade-offs in animal aggregation” in the “Complex Systems” special issue (2 April 1999, p. [99][1]), Julia K.
Applying optical tweezers in vivo : A biophysical study of mechanical forces in Drosophila Melanogaster at the onset of gastrulation

Nous avons developpe un dispositif combinant pinces optiques et imagerie par feuillet de lumiere. Nous montrons que les interfaces cellulaires de l'epithelium precoce de l'embryon de Drosophile peuvent etre piegees et manipulees directement avec des pinces optiques. La manipulation optique est realisee a la fin de la cellularisation, processus par lequel des membranes cellulaires separent les noyaux pour donner naissance a un epithelium ; a ce stade, les mouvements cellulaires sont minimes et les cellules ont des formes hexagonales similaires. En imposant un mouvement sinusoidal au piege perpendiculairement a une interface, nous etudions la deflection de l'interface en fonction de la puissance laser, de l'amplitude du mouvement du piege et de la frequence d'oscillation. En outre, des experiences de deflection-relaxation par deplacement instantane puis arret du piegeage, ont ete realisees, fournissant une alternative a l'analyse frequentielle pour etudier les proprietes viscoelastiques de l'interface. Un modele de type solide lineaire standard rend compte des observations et permet d'extraire les parametres viscoelastiques de l'interface. Nous mettons egalement en evidence que la deflection imposee a une interface se propage aux interfaces voisines en s'affaiblissant exponentiellement sur une distance d'une a deux cellules. Cette technique etant etablie, nous l'utilisons pour mesurer les tensions durant l'extension de la bandelette germinale. Les tensions sont anisotropes, les jonctions paralleles a la direction dorsoventrale ayant une tension trois fois plus elevee que celles perpendiculaires. Ce travail fournit des mesures absolues des tensions intercellulaire.
ine blast algorithm : A new population based algorithm for solving constrained ngineering optimization problems

A novel population-based algorithm based on the mine bomb explosion concept, called the mine blast algorithm (MBA), is applied to the constrained optimization and engineering design problems. A comprehensive comparative study has been carried out to show the performance of the MBA over other recognized optimizers in terms of computational effort (measured as the number of function evaluations) and function value (accuracy). Sixteen constrained benchmark and engineering design problems have been solved and the obtained results were compared with other well-known optimizers. The obtained eywords: ine blast algorithm etaheuristic onstrained optimization ngineering design problems onstraint handling lobal optimization results demonstrate that, the proposed MBA requires less number of function evaluations and in most cases gives better results compared to other considered algorithms. © 2012 Elsevier B.V. All rights reserved.
The planets of the binary star HD 75747

So far it has been assumed that the star system HD 75747, also known as HR 3524 or RS Chamaeleontis (RS Cha), has only one companion. A gravitational wave at 13.86 µ Hz is calculated from the orbital period of 1.67 days. The decoding of the phase modulations of the GW shows eleven companions. The orbital times (cid:28)t very well with the predictions of Dermott’s law, an improved version of the Titus-Bode rule.
Evolution of artificial intelligence for application in contemporary materials science

Contemporary materials science has seen an increasing application of various artificial intelligence techniques in an attempt to accelerate the materials discovery process using forward modeling for predictive analysis and inverse modeling for optimization and design. Over the last decade or so, the increasing availability of computational power and large materials datasets has led to a continuous evolution in the complexity of the techniques used to advance the frontier. In this Review, we provide a high-level overview of the evolution of artificial intelligence in contemporary materials science for the task of materials property prediction in forward modeling. Each stage of evolution is accompanied by an outline of some of the commonly used methodologies and applications. We conclude the work by providing potential future ideas for further development of artificial intelligence in materials science to facilitate the discovery, design, and deployment workflow.
Library Orientation at The Alma Jordan Library: The Way Forward

This paper describes a project undertaken at The Alma Jordan Library of the St. Augustine Campus of The University of the West Indies to pilot a new approach to Library Orientation (LO) at the start of the academic year 2012-2013. The pilot project combined three main components: a virtual tour in the form of a narrated PowerPoint presentation, a hands-on session on navigating the Campus Libraries' electronic information portal, UWIlinC, and a questionnaire designed to gather feedback and test retention from participants. The pilot programme was branded and marketed under the acronym, L.I. F.E. Library Information for Everyone and was incorporated into a newly rebranded campus-wide First Year Experience for students new to the St. Augustine Campus. The programme offered library literacy to new and returning undergraduate and postgraduate students. The pilot was designed to replace a month long programme which included physical library tours conducted over two weeks and subsequent information literacy instruction sessions. The L.I. F.E. programme, offered over a two week period, was approximately one hour long and sessions were held five times daily. The feedback from attending students was overwhelmingly positive. The authors, however, detect that there is still room for growth and improvement. This paper also presents a brief historical overview of the orientation programmes of The Alma Jordan Library, explains why a new programme was proposed, and describes and presents the results of the L.I. F.E. pilot. It ends with a section on lessons learnt; examining the way forward if the orientation programmes at the Library are to be restructured in the future.
Cliques, stable sets, and coloring in graphs with forbidden induced subgraphs

The Gyárfás-Sumner conjecture [29, 42] states that for every tree T , there is a function f such that for every graph G with no induced subgraph isomorphic to T , the chromatic number of G is at most f(ω(G)), where ω(G) is its clique number. We prove this when T is a tree formed by joining two disjoint paths by an edge. A class C of graphs has the EH-property if there is a δ > 0 such that every G ∈ C has a clique or stable set of size at least |V (G)|. The Erdős-Hajnal conjecture [21,22] states that for every graph H, the class of H-free graphs has the EH-property. One approach for proving this is showing that there exists an ε > 0 such that every G ∈ C contains two sets A,B with |A|, |B| ≥ ε|V (G)| and such that either no edges or all edges between the sets are present in G. We prove a conjecture of Liebenau and Pilipczuk [33], that for every tree T , the class of graphs containing neither T nor its complement as an induced subgraph has this property, and thus has the EH-property. This generalizes several previous results [4, 7, 33, 34]. We consider variants obtained by requiring that G is sparse, or A,B have polynomial instead of linear size, or the density between A and B is bounded, or G contains few copies of H. We prove a conjecture of Conlon, Fox and Sudakov [18] for almost bipartite graphs. Our results imply an improved bound for the Erdős-Hajnal conjecture for excluding a five-cycle, the simplest open case. The strong perfect graph theorem [11] contains a decomposition theorem, and even though perfect graphs can be colored in polynomial time [28], no combinatorial algorithm for this is known. One obstacle for such an algorithm are “skew partitions”, which arise from induced subgraphs isomorphic to line graphs. Generalizations of line graphs, so-called orthogonal strip systems, yield particularly bad skew partitions. We prove that in a perfect graph, under mild assumptions, the number of pairwise orthogonal strip systems is bounded by twice the clique number.
Direct and Inverse Cinematic Resolution Calculation using Denavit-Hartenberg Algorithm and Geometric Method for Robot with 5 DOF

– This manuscript aims to shine light on the analysis done for the direct and inverse kinematics of a 5 DOF robot. Where the main objective is to add a 5th degree of freedom to a traditional SCARA robot due to the extent of the study, it was fitting to cover in a more in-depth manner the control system separately to continue to add to the state of the art. It was possible to solve the direct and inverse kinematics of an inverse SCARA robot with 5 DOF using Denavit-Hartenberg algorithm and geometric method, respectively. The Denavit-Hartenberg algorithm solves kinematics based on homogenous transformation matrices to pass through one system to another using the coordinates systems of every joint and link. Geometric method allows to solve complex kinematics in a simplified way by considering just the coordinates that provides finite solutions. A successful control system for an inverse SCARA of 5 DOF could be built using these two methods.
The Instances of Insomnia among Adolescents in High School Addicted to Online Games

Adolescents are often considered more susceptible to online gaming addiction than adults due to their inclination towards novel experiences in pursuit of personal pleasure. However, this addiction can lead to significant health risks, notably insomnia. This study aims to elucidate the prevalence of insomnia among high school students addicted to online games, employing an analytic survey method with a cross-sectional design. The research population consisted of students of State Senior High School in East Luwu the province of South Sulawesi. A sample size of 246 individuals was determined using proportionate stratified random sampling. The research findings reveal that a majority of adolescents engage in mobile gaming for a duration of ≥ 1 hour per day (67.0%). The most frequently played online game is identified as PlayerUnknown's Battlegrounds (32.5%). Online gaming addiction among adolescents falls predominantly within the severe criteria (73.2%), paralleling the severity of insomnia experienced (72.4%). A significant association between insomnia and online gaming addiction among high school adolescents is established (_p_ = 0.026). It is recommended that educational institutions establish peer educators tasked with promoting awareness regarding the adverse impacts of online gaming addiction among fellow students. By fostering literacy on this subject, schools can contribute to a healthier and more balanced gaming behavior among adolescents.
RRS Discovery Cruises 277/278, RAPID mooring cruise report, February - March 2004

This report describes the mooring operations conducted during RRS Discovery Cruises D277 and D278. These cruises were conducted between 26 February 2004 and 30 March 2004, as part of the Natural Environment Research Council (NERC) funded RAPID Programme to monitor the Atlantic Meridional Overturning Circulation at 26.5N. Cruise D277 was from Tenerife to the Bahamas with participants from the Southampton Oceanography Centre (SOC), with cruise D278 a barter cruise also involving participants from the Rosenstiel School of Marine and Atmospheric Science (RSMAS), University of Miami. An array of moorings were deployed across the Atlantic in order to set up a pre-operational prototype system to continuously observe the Atlantic Meridional Overturning Circulation (MOC). This array will be refined and refurbished during subsequent years. The deployed mooring array consisted of 19 moorings from the SOC, with 3 from the RSMAS. Moorings are focused at the Eastern and Western boundaries, along with a grouping at the Mid Atlantic Ridge. The instruments deployed on the array consists of a variety of current meters, bottom pressure recorders and CTD loggers which, combined with time series measurements of the Florida Channel Current and wind stress estimates, will be used to determine the strength and structure of the MOC at 26.5N.