Miracle-dz/UniFAR-FTUs huggingface dataset:
Connections between high-strength concrete columns and normal-strength concrete floors

This thesis discusses the connections between high-strength concrete columns and normal-strength concrete floors. In practical design, considering the advantage of high-strength concrete in taking compression, a continuous HSC column is intersected by NSC floor. It is of great interest to understand the mechanism of load transmission through such type of connection and summarize the general behavior of that. Moreover, it is necessary to investigate possible parameters which may have impacts on the loading capacity. Firstly, literature study was carried out to know existent solutions to this problem. Previous papers and standard codes in different regions were reviewed. Laboratory experiments and proposed equations from literature review were analyzed in this thesis. Different equations were compared, and impacts of parameters were discussed. Seeing deficiencies in previous researches, a numerical experimental program was proposed to investigate the stated problem. Considering advantages in simulating concrete structures, ATENA program was selected as a tool for finite element analysis. Before the parameter study, in order to investigate the general behavior of the connection between HSC column and NSC floor, one standard specimen was constructed. As for the standard specimen, all settings were in accordance with common designs. Only a monotonic load was applied to the structure. The observation and results during the process of loading were recorded and analyzed in this part. The mechanisms of load transmission through the connections were conceived. After that, a parameter study was conducted based on the standard specimen. Four parameters were selected by setting four series of specimens. From series A to D, variables in each series were the concrete strength, the flexural reinforcement in the floor, the aspect ratio (the ratio between the slab thickness to the column width), and the floor loading. Through variable control, each parameter was investigated and their impacts on connections were discussed. At the last, conclusions were drawn regrading to numerical tests. Guidelines for designing a connection between high-strength columns and normal-strength floors were proposed.
An Evaluation of the HEAR and DARE Supplementary Admission Routes to Higher Education

This evaluation stems from an interest from those working on and administering the HEAR and DARE schemes into the effectiveness of the schemes in widening participation in higher education of under-represented groups. A focus of Irish Higher Education (HE) policy is orientated toward the objective of promoting equality of access to higher education, with particular targeted initiatives for under-represented groups. There has been extensive research conducted in Ireland on the issue of Widening Participation (WP), including various evaluative reports on access initiatives of recent years. In addition, universities and colleges have at times undertaken substantial research on their own access programmes and students. However, just three studies to date have focused on the experiences of the HEAR and DARE cohorts, programmes which have been in place in their current format since just 2009. This evaluation seeks address the gap in our knowledge of HEAR and DARE. The DARE/HEAR Strategic Development Group (SDG) has commissioned us to evaluate the following: • To what extent do the schemes meet the target groups’ requirements? • How do the schemes contribute to the realisation of institutional and national targets? and • What can be determined about the sustainability, scaleability and replicability of the schemes? In terms of the data from which this evaluation is based, we adopt a mixed method approach, drawing on a range of existing administrative data sources collected by the HEAR and DARE schemes, the Central Applications Office (CAO) and the Higher Education Authority (HEA); alongside new qualitative data collection with HEAR and DARE students currently in higher education and a number of key internal and external stakeholders. The evaluation, in adopting a mixed method approach, draws on the strengths of these two methods to allow for a better understanding of the profile and experiences of school leavers who access the schemes.
Collapsible Silicone Tubes: An in Vitro Model for Tracheal Traction

COLLAPSIBLE SILICONE TUBES: AN IN VITRO MODEL FOR TRACHEAL TRACTION Kevin Garman Marquette University, 2017 Obstructive sleep apnea (OSA) is characterized by recurrent episodes of airway collapse and airflow limitation during sleep. Fragmented sleep and reductions in blood oxygen saturation lead to several comorbidities, including hypertension, cardiovascular disease, and cerebrovascular disease. Longitudinal forces (tracheal traction) acting on the soft tissues surrounding the upper airway have been proposed to play a significant role in stabilizing the airway and preventing collapse. However, the relative contribution of longitudinal forces as compared to other factors that affect airway stability (airway geometry, tissue properties, muscle activity) remains unclear. This in-vitro study aimed to investigate to what extent longitudinal forces can stabilize the upper airway against flow-induced collapse. Collapsible silicone tubes of varying lengths (L = 75 to 125mm), diameters (D = 12.70 to 31.75mm), and wall thicknesses (h = 0.98 to 2.22mm) were fabricated in-house. An experimental setup was developed that included a pressure catheter to measure air pressure in the tube lumen, a pump that generated sinusoidal bidirectional flow, and a laser line scanner to monitor deformations of the tube wall. The buckling pressure (pressure at which the tube collapses) was quantified as a function of tube geometry and longitudinal stretching. The silicone tubes collapsed at a similar range of transmural pressures (0 to 10 cmH2O) and flowrates (0 to 250ml/s) as observed in the human airway during sleep. Tube length had no clear effect on the buckling pressure, but mechanical stability increased when the wall-thickness-to-radius ratio ( = 2h/D) increased. The buckling pressured measured experimentally was in good agreement with the theory for tubes exposed to transmural pressure alone (zero flow), suggesting that tube collapse was determined primarily by the transmural pressure (rather than by fluid-structure interactions). Longitudinal stretching (5% strain) reduced the buckling pressure by 0.5 to 1.0 cmH2O, which was smaller than the effect of changes in tube diameter and wall thickness. Longitudinal stretching improved the stability of cylindrical silicone tubes, but its effect was smaller than the effect of changes in tube geometry.
Role of Phytoestrogen-Rich Bioactive Substances (Linum usitatissimum L., Glycine max L., Trifolium pratense L.) in Cardiovascular Disease Prevention in Postmenopausal Women: A Systematic Review and Meta-Analysis

The aim of this report was to determine the impact of flaxseed, soy and red clover, and their bioactive substances on the lipid profile in postmenopausal women in cardiovascular diseases prevention. We used the following databases: MEDLINE (PubMed), EMBASE and the Cochrane Library. Meta-analysis indicates that the intake of flaxseed by postmenopausal women is associated with a statistically significant reduction in total cholesterol (TC) levels (weighted-mean difference (WMD) = −0.26; 95% confidence interval (95% CI): −0.38 to −0.13; p = 0.0001), low-density lipoprotein cholesterol (LDL-C) levels (WMD = −0.19; 95% CI: −0.30 to −0.08; p = 0.0006), and high-density lipoprotein cholesterol (HDL-C) levels (WMD = −0.06; 95% CI: −0.11 to −0.01; p = 0.0150). The effect of soy protein on the lipid profile showed a significant decrease in TC levels: WMD = −0.15; 95% CI: −0.25–0.05; p = 0.0048, LDL-C levels: WMD = −0.15; 95% CI: −0.25–0.05; p = 0.0067, as well as a significant increase in HDL-C levels: WMD = 0.05; 95% CI: 0.02–0.08; p = 0.0034. Changes in the lipid profile showed a significant reduction in TC levels after the use of red clover (WMD = −0.11; 95% CI: −0.18–−0.04; p = 0.0017) and a significant increase in HDL-C levels (WMD = 0.04; 95% CI: 0.01 to 0.07; p = 0.0165). This meta-analysis provides evidence that consuming flaxseed, soy and red clover can have a beneficial effect on lipids in postmenopausal women and suggest a favorable effect in preventing cardiovascular diseases.
Analisis Requirement Perangkat Lunak untuk Menjalankan Process Based Assessment (PBA) dalam Pembelajaran Pemrograman Dasar

Tulisan ini menguraikan tentang penerapan prinsip Process Based Assessment (PBA) yang tepat dijalankan dalam pembelajaran pemrograman dasar, serta hasil analisis requirement perangkat lunak untuk mendukung PBA tersebut. Kedua aspek tersebut merupakan luaran dari penelitian tahap pertama dari rencana 3 tahappenelitian, melalui skim penelitian Hibah Bersaing 2014. Telaahmengenai metode pembelajaran pemrograman dasar telah banyak dilakukan. Pelbagai strategi pengajaran telah pula diuji coba dengan pelbagai pendekatan, namun pengajaran pemrograman dasar dipandang selalu menarik untuk diteliti. Para akademisi di pelbagai negara telah berhasil mengangkat isu pengajaran pemrograman dasar dari sudut pandang yang semakin beragam. Dalam kaitannya dengan proses evaluasi, dikenal adanya tes formatif dantes sumatif. Kedua mekanisme evaluasi ini, tepatnya dikaitkan dengan waktu pelaksanaan evaluasi. Formatif ditujukkan untuk mengevaluasi siswa saat proses pembelajaran berlangsung, sedangkan summative dilaksanakan saat proses pembelajaran berakhir. Process based assessment (PBA) adalah suatu implementasi dari evaluasi formatif. Dalam PBA, proses evaluasi dan penilaianberlangsung pada proses belajar siswa, dan bukan melakukan evaluasi terhadap hasil akhir siswa. Berdasarkan analisis dan eksplorasi teknologi maka untuk menjalankan PBA diperlukan sistem perangkat lunak yang mampu menginformasikan proses mikro dari suatu aktivitas pemrograman, misalnya create file/program, Editing(insert, edit, copy-paste, cut, move, delete) file; mampu mengidentifikasi siswa yang sedang masuk ke sistem dan melakukan aktivitas pemrograman, mampu menyimpan informasi mengenai micro-process dari suatu aktivitas pemrograman, setiap siswa; mampu memberikan feedback berdasarkan problem yang teridentifikasi; serta mampu menampilkan secara real time (event-streaming) aktivitas memrogram siswa, dalam pengajaran formal.
Research on transformer condition monitoring based on short time Fourier transform (STFT)

Based on the development and practical application of transformer maintenance technology, this paper solves the core technical problems in on-line monitoring and fault diagnosis of transformer operating conditions. Though the integrated sensor of sound, vibration and temperature, the working conditions and operating state parameters such as sound, vibration and temperature of the transformer are collected. By using network communication to transmit data to the cloud platform for storage, multi-information fusion artificial intelligence modeling is performed on the collected operating conditions and operating status data to obtain an anomaly detection model. An anomaly detection model is deployed on the cloud platform to perform real-time detection on the data collected online, and if the system detects an abnormal state, an abnormality warning is performed. The short-time Fourier transform (STFT) and deep neural network are used to establish a relationship model between monitoring data and transformer faults, and the model is used to realize fault diagnosis.
Influence of KDR Genetic Variation on the Effectiveness and Safety of Bevacizumab in the First-Line Treatment for Patients with Advanced Colorectal Cancer

Objective Bevacizumab is usually considered a first-line anti-tumor therapy, which inhibits tumor growth by downregulating the vascular endothelial growth factor (VEGF) that further silences the activity of the kinase insert region receptor (KDR) gene. In the current study, we investigated the treatment response of bevacizumab in advanced colorectal cancer (CRC) patients bearing 889 C>T mutation in the KDR gene. Methods A total of 135 advanced CRC patients were treated with bevacizumab along with chemotherapy at the seventh medical center of the People’s Liberation Army general hospital from January 2012 to June 2021 and were analyzed retrospectively. The KDR genotyping and mRNA expression analyses were performed in 57 patients. Results The KDR genotyping revealed 97 (71.85%) cases with CC genotype, 34 (25.19%) cases with CT, and 4 (2.96%) cases with TT genotype, while the minor allele frequency of 889 C>T was found as 0.16. The median progression-free survival (PFS) of the patients with CT/TT genotype and CC genotype was found to be 6.1 and 9.7 months, respectively (P = 0.009). The median overall survival (OS) of the two genotypes was 13.7 and 19.7 (P = 0.025), respectively. Multivariable Cox regression analysis of PFS, CT/TT genotype was found to be an independent factor for PFS (odds ratio (OR) = 1.88, P = 0.023). Additionally, the mRNA expression of KDR in 57 biopsies taken from patients with CT/TT genotypes was significantly higher than that of patients with CC genotype (P < 0.001). Additionally, in terms of safety, 55 patients experienced grade 2 or higher fatigue (incidence rate 40.74%) after receiving bevacizumab along with chemotherapy. Conclusion The 889 C>T mutation in KDR gene affects the KDR expression in colorectal cancer patients, thereby affecting the effectiveness of bevacizumab therapy.
Can disorders of subjective time inform the differential diagnosis of psychiatric disorders? A transdiagnostic taxonomy of time

Time is a core aspect of psychopathology with potential for clinical use and early intervention. Temporal experience, perception, judgement and processing are distorted in various psychiatric disorders such as mood (depression and mania), anxiety, autistic, impulse‐control, dissociative and attention‐deficit/hyperactivity disorders. Can these disorders of time be used as early diagnostic or predictive markers? To answer this question, we develop a Transdiagnostic Taxonomy of (disordered) Time (TTT) that maps on to the symptomatological, phenomenal, perceptual and functional descriptions of each underlying disorder in a 2 × 2 × 2 state space. Temporal distortions may precede functional decline, and so assist efforts at early detection and intervention in at‐risk groups.
Human and Technology Leadership Roles in Virtual Teams

Effective leadership can make a difference in the success of a team, and virtual teams are no exception. However, virtual teams present special challenges, particularly in the expression of the context-rich and personal influence that is such an important part of leadership (Bell & Kozlowski, 2002). Communication through computer-mediated channels requires a different awareness of leadership roles and how they can be expressed. In fact, the communication system itself has roles to play, some of which might be perceived by team members as leadership roles. We begin with a brief summary of the historical context of leadership and existing research on leadership in computer-supported teams. We then discuss opportunities for research on enhancing leadership in virtual teams, particularly from the perspective of integrating human with technology roles.
Surveillance and privacy as coevolving disruptions: reflections on “notice and choice”

Abstract The last two decades have seen a dramatic rise in the ways governments, private industry, and other interests can access, gather, analyze, and employ information about citizens. Given the unique roles of practitioners from both the public and private sectors in this policy ecosystem, we lay conceptual groundwork for coevolving technological, business, and policy disruptions. We focus on the “notice and choice” framework (which we consider a type of nudge) given changing conceptions of privacy in a world of evolving norms. Finally, we consider the difficult problem of clear guideposts for policy actors as they try to reconcile public demands for privacy with competing interests.
Fear of Pain as a Predictor for Postoperative Pain Intensity among the Patients Undergoing Thoracoscopic Surgery

Background Fear of pain (FOP) has been recognized as an influential moderator and determinant of the perception and disability of chronic pain. However, studies on FOP in postoperative acute pain are few and inconsistent. Objective To explore whether FOP is related to pain intensity after thoracic surgery and provide a reference for FOP study in postoperative pain. Methods From February to March 2022, 89 patients completed Chinese Version of Fear of Pain-9 Items (FOP-9), Chinese version of the Brief Pain Inventory (BPI, including least, worst, and average pain) and Simplified Chinese version of the Pain Catastrophizing Scale (PCS). Correlation analyses and mediation analyses were used for exploring the relationship between factors. Results Mediation analyses showed that the total effects of FOP-9 on BPI all were significant (least pain: effect = 0.085, p=0.013, 95% CI = 0.019∼0.151; worst pain: effect = 0.116, p=0.004, 95% CI = 0.037∼0.196; average pain: effect = 0.102, p=0.005, 95% CI = 0.031∼0.174) indicating that FOP-9 was a predictor to BPI. The 95% bias-corrected bootstrap confidence interval of estimate of indirect effect between FOP-9 and least pain/average pain through PCS was −0.036∼0.024 and −0.003∼0.069 (all contain zero), which indicated that PCS is not a mediator between FOP-9 and least pain/average pain. However, the estimate of indirect effect between FOP-9 and worst pain through PCS were 0.048 (95% CI = 0.095∼0.088), and direct effect was not statistically significant (95% CI = −0.017∼0.153), indicating that PCS acted as a complete intermediary between FOP-9 and worst pain. FOP-9 and PCS showed significant positive prediction effect on worst pain. Conclusions Both trait FOP and state FOP were associated with higher postoperative pain reports after thoracic surgery. Trait FOP influences postoperative pain through the mediating effect of state FOP.
Home appliance integrity detection model based on improved YOLOv4-Tiny

To realize the rapid detection of missing items in home appliances, we proposed a new method based on an improved YOLOv4-Tiny model. Mosaic and Mixup data augmentation methods are used to enrich image data sets, and the SE-Block module is used to apply an attention mechanism on the channels of the feature layer. Experiments show that: The mAP and Recall of the improved YOLOv4-Tiny model proposed in this paper are 97.55% and 95.31%, respectively, which are 3.64% and 5.17% higher than the original YOLOv4-Tiny model, and the FPS reaches 181. The model accuracy is improved without losing detection speed. The proposed method provides technical support for detecting missing items of household appliances.
Traditional Chinese Medicine for Post-stroke Sleep Disorders: The Evidence Mapping of Clinical Studies

Background and Purpose Recently, there are a number of clinical studies on traditional Chinese medicine (TCM) for post-stroke sleep disorders (PSSDs). This study aimed to map the current clinical studies and identify gaps to inform future study agendas. Methods PubMed, Embase, Cochrane Library, and Chinese databases, including SinoMed, CNKI, and Wanfang, were searched for clinical studies on PSSDs treated with TCM from their inception to September 2021. Evidence sources, number of studies, types of PSSDs, intervention categories, effectiveness, and quality assessment were graphically displayed. Results The evidence map involved 810 clinical studies, of which the earliest report was dated back to 1993, and an advanced growth of the whole evidence was observed in 2012. Randomized controlled trials (RCTs) were the most common type of study design (78.15%), and post-stroke insomnia was the most common type of sleep disorders (65.80%). The benefits of Chinese herbal medicine (CHM) and acupuncture therapies for post-stroke insomnia have been widely reported in RCTs (81.60% and 75.38%, respectively). However, the benefits of CHM interventions were assessed using a global approach rather than being based on a specific formula, and the highest level of evidence supporting the effectiveness of acupuncture therapies was of low methodological quality. In addition, evidence from primary studies was insufficient in the areas of TCM for post-stroke sleep-related breathing disorders (SBDs) and Chinese mind-body exercises for post-stroke insomnia. Conclusions PSSDs treated with TCM have been widely assessed in clinical studies. For better evidence translation, clinical trials on specific CHM interventions and high-quality systematic reviews on acupuncture for post-stroke insomnia should be conducted. For a better solution to clinical questions, TCM on SBDs after stroke and the benefits of Chinese mind-body exercises for post-stroke insomnia should be explored in future clinical studies.
Abstract 2984: ARHGAP17, a Cdc42-specific GAP, localizes to invadopodia and regulates their turnover as part of an ARHGAP17/Cdc42/CIP4 complex

One of the hallmarks of aggressive cancer is its ability to invade into surrounding tissues and metastasize. Many invasive cancers form invadopodia, which are protrusive, degradative structures that are regulated by the Rho family of GTPases. Rho GTPases commonly have aberrant activity in invasive cancers caused by changes in their upstream regulators: RhoGEFs and RhoGAPs. We have identified the RhoGAP ARHGAP17 (RICH1/NADRIN) as a negative regulator of invadopodia in triple negative breast cancer. Using confocal and STORM super-resolution microscopy techniques, we show that ARHGAP17 localizes to the regulatory ring surrounding invadopodia where it acts to promote disassembly by decreasing invadopodia lifetime through the inactivation of the Rho GTPase Cdc42. We further support these results in live cells by using a new localization-based Cdc42 biosensor, which reveals that ARHGAP17 suppresses Cdc42 activity specifically at the invadopodia ring. We have also identified the Cdc42 effector CIP4 as part of a complex with ARHGAP17 and Cdc42 that we propose is key in the regulation of invadopodia. Finally, using spheroid and inverse invasion assays, we show that the invadopodia phenotype correlates with increased invasive properties. In conclusion, we have identified ARHGAP17 as a key regulator of invadopodia and invasion in triple negative breast cancer by localizing to invadopodia and inactivating Cdc42 as part of a complex with CIP4. In future studies, we will further characterize the molecular mechanisms that regulate the ARHGAP17/Cdc42/CIP4 complex and their function during invadopodia formation. Citation Format: Gabriel Kreider-Letterman, Abel Castillo, Agustin Rabino, Eike K. Mahlandt, Joachim Goedhart, Silvia Goicoechea, Rafael Garcia-Mata. ARHGAP17, a Cdc42-specific GAP, localizes to invadopodia and regulates their turnover as part of an ARHGAP17/Cdc42/CIP4 complex [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2984.