Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular Mechanism of Curcumin Derivative on YAP Pathway against Ovarian Cancer

The purpose of this study is to study the effect of curcumin derivative WZ10 on the proliferation, invasion and apoptosis of ovarian cancer OVCAR3 cells, and to explore its mechanism. MTT assay was used to detect the effect of WZ10 on the proliferation of ovarian cancer OVCAR3 cells; Annexin V/PI double staining flow cytometry was used to detect the effect of WZ10 on cell apoptosis; Transwell method was used to detect the effect of WZ10 on cell invasiveness; Western blot was used to investigate the effect of WZ10 Mechanisms affecting OVCAR3 activity in ovarian cancer in vitro. Our results show that WZ10 treatment could significantly inhibit the proliferation and invasion of OVCAR3 cells, induce apoptosis of OVCAR3 cells in a dose-dependent manner. After knockdown of Hippo expression with sh-RNA, further combined treatment with WZ10 had no significant image on ovarian cancer OVCAR3 cells. In conclusion: WZ10 can significantly inhibit the proliferation of OVCAR3 cells, reduce cell invasion and proliferation by downregulating the activation of Hippo-YAP pathway, and induce cell apoptosis.
Characteristics of Electron Emission from a (Pb,La)(Zr,Ti)O3 Ferroelectric Cathode

The properties of electron emission from a poled lead lanthanum zirconate titanate (PLZT) ferroelectric cathode have been investigated on the dependence of operating parameters such as the driving voltage, the vacuum pressure, the diode gap distance, and the diode acceleration voltage. The threshold electric field for electron emission from the cathode is about 6 kV/cm and the emitted current increase with increase in the driving voltage. A maximum current of 37 A/cm2 has been detected when the driving voltage is -1.4 kV and the gap distance is 20 mm. The electron emission is considered to be initiated by field emission and then possibly be enhanced by the surface plasma. To confirm the detailed emission process, however, further experimental study should be necessitated.
Receiver operating characteristic curves and fusion of multiple classifiers

A classifier typically has parameters in them that can vary. thus a classifier is, in fact, a family of classi- fiers. Varying the parameters and graphing the probability of false positive verse probability of true positive yields the Receiver Operating Characteristic (ROC) curve. Given a collection of multiple classifiers, and assume the Receiver Operating Characteristic (ROC) curve is know for each classifier. Can the ROC curve for the fused classifier be determined? We answer this question in this paper: This paper also present a unique the representation of thefusion of multiple where the fusion is based on Boolean rules.
A Novel and Fast Method for Content-Based Image Retrieval via Stack-Triangles Geometrics Histogram

In this paper, a novel method is proposed for solving an open problem of shape matching in content-based image retrieval. Our method regards the stack-triangles geometrics histogram to be the feature of an image, the correlation of two images was decided by the compare result of their stack-triangles geometrics histograms. First of all, these methods extract the key contour fragments of an image, so that a shape can be presented as many key contour fragments in this way. In addition, we derivation stack triangles of a shape by the key contour fragments we get it before. Then, we can get the stack-triangles geometrics histogram of the image and calculate the correlation of two images use their stack-triangles geometrics histogram. Finally, experiment results show that our new method is a very fast method and can get more robustness than existing methods and achieve a good effect in the standard shape databases MPEG-7.
The Phase Retrieval Problem

A method for solving the phase retrieval problem is proposed. The method consists of measuring the modulus of the Fourier transform of the unknown function and the modulus of the Fourier transform of the product of the unknown function and an exponential. From these two measurements, the location of the complex zeros of the analytic continuation of the Fourier transform of the unknown function may easily and quickly be deduced and the unknown function constructed.
Tumor-Derived Small Extracellular Vesicles Involved in Breast Cancer Progression and Drug Resistance

Breast cancer is one of the most serious and terrifying threats to the health of women. Recent studies have demonstrated that interaction among cancer cells themselves and those with other cells, including immune cells, in a tumor microenvironment potentially and intrinsically regulate and determine cancer progression and metastasis. Small extracellular vesicles (sEVs), a type of lipid-bilayer particles derived from cells, with a size of less than 200 nm, are recognized as one form of important mediators in cell-to-cell communication. sEVs can transport a variety of bioactive substances, including proteins, RNAs, and lipids. Accumulating evidence has revealed that sEVs play a crucial role in cancer development and progression, with a significant impact on proliferation, invasion, and metastasis. In addition, sEVs systematically coordinate physiological and pathological processes, such as coagulation, vascular leakage, and stromal cell reprogramming, to bring about premetastatic niche formation and to determine metastatic organ tropism. There are a variety of oncogenic factors in tumor-derived sEVs that mediate cellular communication between local stromal cells and distal microenvironment, both of which are important in cancer progression and metastasis. Tumor-derived sEVs contain substances that are similar to parental tumor cells, and as such, sEVs could be biomarkers in cancer progression and potential therapeutic targets, particularly for predicting and preventing future metastatic development. Here, we review the mechanisms underlying the regulation by tumor-derived sEVs on cancer development and progression, including proliferation, metastasis, drug resistance, and immunosuppression, which coordinately shape the pro-metastatic microenvironment. In addition, we describe the application of sEVs to the development of cancer biomarkers and potential therapeutic modalities and discuss how they can be engineered and translated into clinical practice.
Modular elliptic directions with complex multiplication (with an application to Gross’s elliptic curves)

Let Af be the abelian variety attached by Shimura to a normalized newform f? S2(? 1(N)) and assume that Af has elliptic quotients. The paper deals with the determination of the one dimensional subspaces (elliptic directions) in S2(? 1(N)) corresponding to the pullbacks of the regular differentials of all elliptic quotients of Af. For modular elliptic curves over number fields without complex multiplication (CM), the directions were studied by the authors in [8]. The main goal of the present paper is to characterize the directions corresponding to elliptic curves with CM. Then we apply the results obtained to the case N=p2, for primes p>3 and p? 3 mod 4. For this case we prove that if f has CM, then all optimal elliptic quotients of Af are also optimal in the sense that its endomorphism ring is the maximal order of Q(-p---? ). Moreover, if f has trivial Nebentypus then all optimal quotients are Gross�s elliptic curve A(p) and its Galois conjugates. Among all modular parametrizations J0(p2)? A(p), we describe a canonical one and discuss some of its properties.
Synthesis a New Series of Methenamine Complexes with Some Different Metal Ions : Spectral , Thermal and Biological Investigations

In this paper methenamine (HMTA) ligand acts as monodentate with each central atom in all isolated complexes although the ligand molecule possesses four potential donor atoms through three fused rings in the chair configuration with four bridges – head nitrogen atoms. The nitrogen atoms of this donor may permeate the coordination towards multinucleous of metal atoms. This behavior may be due to the shape of the ligand distribute the donor atoms by the shape leads to this coordination. Ag(I), Cd(II), Cu(II), Hg(II), Sn(II), Sn(IV), Sb(III), Bi(III), Ce(III), Sm(III) and La(III) are the metal ions concerned this study. In the infrared spectra the shift in υ(C-N) bands proposed the type of coordination mode. The HNMR spectra of Sn(II) and Bi(III) complexes are further supported for the proposed chelation. The XRD study for some selective complexes reflects their amorphous nature. The thermal behavior of these chelates shows that the hydrated complexes losses water molecules of hydration and coordination at relatively higher temperature. This is due to the presence of hydrated molecules introduced by H – bonding inside the coordination sphere with the active ligand centers followed immediately by decomposition of anions and ligand molecules in the subsequent steps. The activation thermodynamic parameters as; E*, ΔH*, ΔS* and ΔG* are calculated from the TG curves using Coats – Redfern method for suitable TG curves in between the all, which display peaks in between sharpness and broadness. The ligand in comparison to some of complexes was screened for their antibacterial and antifungal activities. The application was concerned in this study with focusing on some special complexes chosen referring to their history of their distinguish activity. The activity data show the investigated metal complexes to be more potent than the parent organic against most species. [Soha F. Mohammed, Moamen S. Refat and Nashwa M. El–Metwaly. Synthesis a New Series of Methenamine Complexes with Some Different Metal Ions: Spectral, Thermal and Biological Investigations. Life Sci J 2012;9(2):1243-1253] (ISSN: 1097-8135). http://www.lifesciencesite. com. 185
Pseudo-bulge formation via major mergers

It is widely accepted that within the framework of Λ cold dark matter a significant fraction of giant-disc galaxies has recently experienced a violent galactic merger. We present numerical simulations of such major mergers of gas-rich pure disc galaxies, and focus on the innermost stellar component (bulge) of the disc remnants. The simulations have high spatial and mass resolutions, and resolve regions deep enough to allow bulge classification according to standard kinematical and structural characteristics. In agreement with recent studies we find that these bulges are dominated by stars formed in the final coalescence process. In contrast to the common interpretation of such components as classical bulges (i.e. similar to intermediate-luminosity ellipticals), we find that they are supported by highly coherent rotations and have Sersic indices n < 2, a result leading to their classification as pseudo-bulges. Pseudo-bulge formation by gas-rich major mergers of pure discs is a novel mode of pseudo-bulge formation; it complements pseudo-bulge growth by secular evolution, and it could help explain the high fractions of classically bulgeless giant-disc galaxies, and pseudo-bulges found in giant Sc galaxies.
Kinematics Analysis of Male Runners via Forefoot and Rearfoot Strike Strategies: A Preliminary Study

This study aimed to explore the kinematic characteristics of males using various foot landing strategies. The participants were fifteen male students from Physical Education College, Huaibei (non-professional runners, who did not have a fixed running landing strategy mode) (mean height = 178.20 cm; mean weight = 67.60 kg; mean age = 19.40 years). In this experiment, the running model of different foot landing strategies (forefoot strike, FFS and rearfoot strike, RFS) were analyzed using two high-speed cameras captured simultaneously at a sampling rate of 100 Hz. According to the results, the runners with better sports performance have shorter contact time, longer flight time, lower duty factor, larger stride angle, faster V COG, greater A COG, and knee and ankle angles which were crucial kinematics factors to enhance the running. Therefore, this study recommends that coaches or researchers can use photography to analyze novice runners who do not have a fixed landing pattern when running with RFS, the characteristics of running style was closely related to the flight times, and running with FFS was closely related to the stride angle.
Optimization method of one-dimensional standard calibration based on laser tracking interferometry

In order to improve the robustness of the traditional laser tracking interferometry method and make the calibration results of the one-dimensional standard more accurate and reliable, a laser tracking interferometry calibration optimization method in multiple attitudes is proposed in this paper. The method firstly constructs a multi-stance 1D standard layout based on the traditional laser tracking interferometric length measurement, and collects measurement information under different attitudes by laser tracker, then uses a weight-based calibration result optimization strategy to optimize the combination of measurement data, and then outputs the calibration results and performs error source analysis and uncertainty assessment. The experimental analysis was carried out and compared with the CMM method, and the En value was 0.1, which verified the reasonableness of the uncertainty assessment, and the comparison with the measurement results of the CMM method showed that the calibration optimization scheme for multiple poses was more reliable than that for single poses. The optimized method provides a new calibration scheme for realizing the quantity traceability of high-precision one-dimensional standard, which has good practicality and certain guiding significance.
LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator

LIM and SH3 protein 1 was originally identified as a structural cytoskeletal protein with scaffolding function. However, recent data suggest additional roles in cell signaling and gene expression, especially in tumor cells. These novel functions are primarily regulated by the site-specific phosphorylation of LASP1. This review will focus on specific phosphorylation-dependent interaction between LASP1 and cellular proteins that orchestrate primary tumor progression and metastasis. More specifically, we will describe the role of LASP1 in chemokine receptor, and PI3K/AKT signaling. We outline the nuclear role for LASP1 in terms of epigenetics and transcriptional regulation and modulation of oncogenic mRNA translation. Finally, newly identified roles for the cytoskeletal function of LASP1 next to its known canonical F-actin binding properties are included.
Spontaneous parametric down-conversion in waveguides: A backward Heisenberg picture approach

We develop a fully quantum-mechanical approach for the description of spontaneous parametric down-conversion in waveguides. Our method allows us to write an expression for the quantum state easily and directly, even when multiple photon pairs are generated in the process. The role of material dispersion in the normalization of the modes of the system, usually neglected, is properly treated here. The example of an ${\text{Al}}_{y}{\text{O}}_{x}/{\text{Al}}_{0.5}{\text{Ga}}_{0.5}\text{As}$ ridge waveguide is discussed to illustrate the application of the formalism.
Application of Smoothed Particle Hydrodynamics to Full-Film Lubrication

An in-house solver was created in order to simulate hydrodynamic lubrication utilizing smoothed particle hydrodynamics (SPH). SPH is a meshfree, Lagrangian, particle-based method that can be used to solve continuum problems. In this study, transient hydrodynamic lubrication in a pad bearing geometry was modeled utilizing the SPH method. The results were validated by comparison to computational fluid dynamics (CFD) and an analytical solution provided by lubrication theory. Results for the pressure distribution between SPH and CFD were agreeable while lubrication theory failed to capture any inertial effects of the fluid. Velocity profile comparisons differed slightly between all three methods. However, since smoothed particle methods have been shown to have the advantage of being able to model large deformations, as well as allowing easy definitions of fluid-solid interfaces, they can be useful tools for complex problems in tribology.
A Nanoflare Explanation for the Heating of Coronal Loops Observed by Yohkoh

The nanoflare model of Cargill (1994a) is used to model active region loops observed by the Yohkoh Soft X-ray Telescope (SXT). Using observed information concerning the dimensions and energy-loss rate of each loop, a range of loop models with different temperatures, emission measures, and filling factors is generated. For hot loops (T > 4 × 106 K), it is shown that filling factors less than 0.1 can fit the data, although the uncertainties can be quite large. For cool loops (T ≈ 2 × 106 K), the model cannot reproduce the observed temperature and emission measure for any value of the filling factor. Earlier work of Porter & Klimchuk suggested that some of these loops cannot be explained by a steady state heating model either. It is proposed that there may exist two distinct classes of loops and that coronal material is injected into the cooler loops by a mechanism that is not directly related to heating (e.g., not chromospheric evaporation).
Cumulative compressibility effects on population dynamics in turbulent flows

Bacteria and plankton populations living in oceans and lakes reproduce and die under the in- fluence of turbulent currents. Turbulent transport interacts in a complex way with the dynamics of populations because the typical reproduction time of microorganism is within the inertial range of turbulent time scales. In the present manuscript we quantitatively investigate the effect of flow compressibility on the dynamics of populations. While a small compressibility can be induced by several physical mechanisms, like density mismatch or the finite size of microorganisms with respect to the fluid turbulence, its effect on the the carrying capacity of the ecosystem can be dramatic. We report, for the first time, how a small compressibility can produce a sizeable reduction in the carrying capacity, due to an integrated effect made possible by the long replication times of the organisms with respect to turbulent time scales. A full statistical quantification of the fluctuations of population concentration field leads to data collapse over a broad range in parameter space.
Wavelet Threshold Estimation of a Regression Function with Random Design

The wavelet threshold estimator of a regression function for the random design is constructed. The optimal uniform convergence rate of the estimator in a ball of Besov Space Bsp, q is proved under general assumptions. The adaptive wavelet threshold estimator with near-optimal convergence rate in a wide range of Besov scale is also constructed.
Construction and Experimental Realization of the Fractional-Order Transformer by Oustaloup Rational Approximation Method

In previous studies, there were few application circuits involving fractional-order mutual-coupling circuits. Therefore, based on the fractional mutual coupling circuit, the Oustaloup rational approximation method is proposed to construct fractional transformers. Firstly the fractional-order transformer circuit model is derived based on the fractional-order coupled inductor. And the frequency characteristics of the impedance of the fractional-order transformer under open-circuit and load conditions are analyzed. Then different orders of fractional transformers are constructed to verify the rationality of the proposed circuit by simulation. Finally, two fractional-order transformers with different orders constructed, and simulations and experiments show that the constructed circuit has good electrical approximation performance.
Universal relation between viscous flow and fast dynamics in glass-forming materials

Glass-forming liquids can cross the melting line avoiding crystallization, and upon cooling below the melting temperature, their viscosity increases by several orders of magnitude, eventually leading to the glass transition. This is a kinetic transition usually defined by the condition in which the structural relaxation time the process equals a given value, arbitrarily fixed to 100 s. At the glass transition temperature, Tg, the shear viscosity of most systems is in the range of 10 11 10 13 poise, values high enough to consider the system as “solid” from the mechanical point of view. The rapidity of the increase in the viscosity when approaching Tg from the liquid side led in the scientific community to the classification of glasses into long and short, 1 a concept widespread by Angell introducing the kinetic “fragility” 2
On the Stokes V Amplitude Ratio as an Indicator of the Field Strength in the Solar Internetwork

The results of the determination of magnetic field strength from weak polarimetric signals in solar internetwork regions are contradictory. We investigate the origin of this contradiction with the help of MHD simulations. It is shown that the Stokes V amplitude ratio of the Fe I λλ15652-15648 lines is a good indicator of kG magnetic field concentrations, even for magnetic fields with a complex internal structure like those in MHD simulations. The Stokes V amplitude ratio of the Fe I λλ5247-5250 lines also shows a good correlation with magnetic field strength. However, in simulations with a flux level appropriate for the internetwork, it gives values corresponding to sub-kG fields. The reason is the rapid decrease of the field strength with height in kG magnetic field concentrations. These lines sample high regions of the atmosphere, where the field is already below kG levels. We also find that the Stokes V amplitude ratio of the Fe I λλ6301-6302 lines shows no correlation with the magnetic field strength. The reason lies in the large difference in the heights of formation of these two lines. The value of the magnetic field strength obtained from the Fe I λλ6301 and 6302 lines depends crucially on the treatment of gradients of the magnetic field, line-of-sight velocity, and temperature, even at a numerical spatial resolution of 20 km.
Agent-based modelling for early-stage optimization of spatial structures

Agent-based modelling (ABM) is a complex problem-solving approach that can be employed in early-stage parametric design, and certain design applications may benefit from such a bottom-up strategy. This research investigates the potential of ABM for structural design optimization. A case study of a form-found cantilevered truss is presented that has a doubly curved shape over a regular grid, resulting in individual members with different lengths across the structure. It is hypothesized that an agent-based approach might generate an irregular grid of similar or better structural performance, but with more uniform length of individual elements. This approach could be useful when designing a global structural form from a kit of parts or adaptively reusing a disassembled existing structure with regular member lengths. A series of ABM simulations are conducted with different hyperparameters, and the generated designs are compared to the original form-found shape in terms of structural performance.
On the Discovery of Two New Monoclinic Phases in the Morphotropic Phase Boundary Region of Pb[(Mg1/3Nb2/3)O3]-xPbTiO3 Ceramics

Profile analysis of powder x-ray and neutron diffraction data on (1−x)[Pb(Mg 1/3 Nb 2/3 )O 3 ]-xPbTiO 3 (PMN-xPT) confirms the presence of two monoclinic phases with space groups Cm and Pm in the morphotropic phase boundary (MPB) region sandwiched by the rhombohedral and tetragonal phase fields. The phase transition sequence R-M B -O-M C -T predicted by Vanderbilt and Cohen for 3π/4 < β < 0. 8π may indeed correspond to the composition dependent change of structure in the PMN-xPT system.