Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of Locally Produced Adipokines and Their Receptors during Different Physiological and Reproductive Stages in the Bovine Corpus Luteum

Simple Summary Adipokines are cytokines secreted by adipose tissue that play a crucial role in several biological processes, including energy balance, food intake, immune status, and reproduction. Research has shown that there is a close correlation between energy balance, metabolism, and reproductive function in mammals. Among these factors, ovarian physiology has been found to have its own local regulation. In this study, we aimed to gain insight into the local production of novel adipokines and their receptors in the corpus luteum of cycling and pregnant cows. We examined corpora lutea at various stages in cycling and pregnant cows to investigate the involvement of locally produced adipokines and their receptors in ovarian physiology. Our findings reveal significant differences in the expression levels of adipokines throughout the estrous cycle and pregnancy, indicating their potential role in corpus luteum lysis and/or resumption of cyclicity. Abstract This study aimed to determine the gene expression of different local novel adipokines, such as vaspin, adiponectin, visfatin, and resistin, and their known receptors, namely, heat shock 70 protein 5, adiponectin receptor 1, and adiponectin receptor 2, in the bovine corpus luteum (CL) during different phases of the estrous cycle (on days 1–2, 3–4, 5–7, 8–12, 13–18, >18) and pregnancy (at months 1–2, 3–4, 5–7, >7). The mRNA expression was measured by reverse transcription polymerase chain reaction (RT-qPCR). The mRNA expression levels were normalized to the geometric mean of all three constantly expressed reference genes (cyclophilin A, ubiquitin, ubiquitin C). Our findings suggest that adipokines are expressed and present in all investigated groups, and are specifically up- or downregulated during the estrus cycle and during pregnancy. Vaspin and adiponectin levels were upregulated in the middle and late cycle stages. Resistin was abundant during the CL regression stage and in the first months of pregnancy. The specific expression of adipokine receptors indicates their involvement in the local mechanisms that regulate CL function. Further investigations are required to elucidate the regulative mechanisms underlying the different local effects of adipokines on the ovarian physiology of cows.
Progressive Classifier Mechanism for Bridge Expansion Joint Health Status Monitoring System Based on Acoustic Sensors

The application of IoT (Internet of Things) technology to the health monitoring of expansion joints is of great importance in enhancing the efficiency of bridge expansion joint maintenance. In this study, a low-power, high-efficiency, end-to-cloud coordinated monitoring system analyzes acoustic signals to identify faults in bridge expansion joints. To address the issue of scarce authentic data related to bridge expansion joint failures, an expansion joint damage simulation data collection platform is established for well-annotated datasets. Based on this, a progressive two-level classifier mechanism is proposed, combining template matching based on AMPD (Automatic Peak Detection) and deep learning algorithms based on VMD (Variational Mode Decomposition), denoising, and utilizing edge and cloud computing power efficiently. The simulation-based datasets were used to test the two-level algorithm, with the first-level edge-end template matching algorithm achieving fault detection rates of 93.3% and the second-level cloud-based deep learning algorithm achieving classification accuracy of 98.4%. The proposed system in this paper has demonstrated efficient performance in monitoring the health of expansion joints, according to the aforementioned results.
Folic Acid Supplementation Promotes Hypomethylation in Both the Inflamed Colonic Mucosa and Colitis-Associated Dysplasia

Simple Summary Ulcerative colitis, a form of inflammatory bowel disease, is a major risk factor for developing colorectal cancer. Patients with ulcerative colitis often present with low serum folate levels due to the adverse effect of maintenance therapies and/or intestinal malabsorption and require folic acid supplementation. While folic acid supplementation confers protection against sporadic colorectal cancer when given prior to colon tumor formation, it can promote cancer formation when administered to mice with early colonic lesions. Few studies have focused on the impact of folic acid on colorectal cancer risk in patients with ulcerative colitis. In this study, folic acid supplementation created a hypomethylated field within the inflamed non-neoplastic colonic mucosa of mice with colitis and promoted the formation of colitis-associated tumors. These data suggest that caution should be taken when recommending folic acid supplements to patients with ulcerative colitis who are at high risk of colorectal cancer. Abstract Purpose: The purpose of this study was to assess the effect of folic acid (FA) supplementation on colitis-associated colorectal cancer (CRC) using the azoxymethane/dextran sulfate sodium (AOM/DSS) model. Methods: Mice were fed a chow containing 2 mg/kg FA at baseline and randomized after the first DSS treatment to receive 0, 2, or 8 mg/kg FA chow for 16 weeks. Colon tissue was collected for histopathological evaluation, genome-wide methylation analyses (Digital Restriction Enzyme Assay of Methylation), and gene expression profiling (RNA-Seq). Results: A dose-dependent increase in the multiplicity of colonic dysplasias was observed, with the multiplicity of total and polypoid dysplasias higher (64% and 225%, respectively) in the 8 mg FA vs. the 0 mg FA group (p < 0.001). Polypoid dysplasias were hypomethylated, as compared to the non-neoplastic colonic mucosa (p < 0.05), irrespective of FA treatment. The colonic mucosa of the 8 mg FA group was markedly hypomethylated as compared to the 0 mg FA group. Differential methylation of genes involved in Wnt/β-catenin and MAPK signaling resulted in corresponding alterations in gene expression within the colonic mucosa. Conclusions: High-dose FA created an altered epigenetic field effect within the non-neoplastic colonic mucosa. The observed decrease in site-specific DNA methylation altered oncogenic pathways and promoted colitis-associated CRC.
Une application du Théorème de Riemann-Roch combinatoire au polynôme d'Ehrhart des polytopes entiers de Rd

Le Theoreme de Riemann-Roch combinatoire ([8], [9], [6]) relie le volume d'un polytope a sommets entiers de R d au nombre de points entiers de ce polytope. Il n'est valable que pour des polytopes dont l'eventail est primitif (la variete torique associee est lisse). Pourtant, en appliquant convenablement ce theoreme, on en deduit une formule explicite pour le coefficient de degre (d-2) du polynome d'Ehrhart de tout polytope entier de R d . On obtient ainsi une formule explicite pour le polynome d'Ehrhart de tout polytope entier de R 4
THE RECENT INVESTIGATIONS ABOUT SOLAR-WEATHER RELATIONSHIP IN FOREIGN COUNTRIES

In this paper the studies of solar-weather relationship during the recent 15 years are reviewed. At first, the modern views about the structures of solar surface and solar atmosphere are introduced. The definition of solar-activity and the physical processes oc-cured on the sun,which cause changes in the region of ultra-violet and radio wave of the sun's electromagnetic radiation as well as that of sun's corpuscular radiation, are discussed. Then the chief achievements about the investigations on the problem of solar-weather relationship are given. Finally some theories about the physical mechanism of soJar-weather relationships and the importance of the studies on this problem in the extended weather forcasting as are commented.
Dot lasers: isotropic droplets in a cholesteric matrix, and vice versa

We have measured lasing spectra from dye-doped droplets of an isotropic liquid located in a cholesteric matrix ('inverted' suspension) and an 'inverse' system, dye-doped cholesteric droplets in an isotropic liquid ('conventional' suspension), with the both systems involving the same cholesteric and isotropic liquid components. For the conventional suspension, we have collected the lasing spectra for about 200 droplets and found that the lasing lines are clearly separated into three groups located at the short-wavelength and long-wavelength edges of a photonic band gap (PhBG) and inside the PhBG. The latter ('forbidden') line is observed for all of the droplets under examination. Occasionally, it can coexist with one or both of the lines located at the short- or/and long-wavelength PhBG edges. We have shown for the first time that, for the inverted isotropic droplets in the cholesteric matrix, a single lasing line is located at the short-wavelength PhBG edge. This reveals a PhBG-nature of that line and corresponds to a zero scalar orientational order parameter for the dye molecules placed in the isotropic liquid.
A COMBINATION OF PSEUDO-SPECTRAL METHOD AND EXTRAPOLATION FOR SOLVING MHD FLOW AND HEAT TRANSFER ABOUT A ROTATING DISK

The objective of this study is to implement a numerical method which is a combination of pseudo-spectral collocation method with a positive scaling factor and extrapolation for solving steady, laminar, incompressible, viscous and electrically conducting fluid of the boundary layer flow due to a constant temperature rotating disk subjected to a uniform suction and injection through its surface in the presence of a uniform transverse magnetic field. These equations are obtained from the Navier Stokes equations through the similarity transformations introduced by Von Karman in 1921. The proposed solution is equipped by the Chebyshev polynomials that have perfect properties to achieve this goal. This method solves the problem on the semi-infinite domain without truncating it to a finite domain. In addition, the presented method reduces solution of the problem to solution of a system of algebraic equations. The obtained numerical solutions are verified by the previous results in the literature. Keywords– Navier stokes equations, MHD flow, rotating disk, suction and injection, Chebyshev polynomials, pseudo-spectral method, extrapolation, scaling factor
Solid-State Fermentation: Applications and Future Perspectives for Biostimulant and Biopesticides Production

With the expansion of the green products market and the worldwide policies and strategies directed toward a green revolution and ecological transition, the demand for innovative approaches is always on the rise. Among the sustainable agricultural approaches, microbial-based products are emerging over time as effective and feasible alternatives to agrochemicals. However, the production, formulation, and commercialization of some products can be challenging. Among the main challenges are the industrial production processes that ensure the quality of the product and its cost on the market. In the context of a circular economy, solid-state fermentation (SSF) might represent a smart approach to obtaining valuable products from waste and by-products. SSF enables the growth of various microorganisms on solid surfaces in the absence or near absence of free-flowing water. It is a valuable and practical method and is used in the food, pharmaceutical, energy, and chemical industries. Nevertheless, the application of this technology in the production of formulations useful in agriculture is still limited. This review summarizes the literature dealing with SSF agricultural applications and the future perspective of its use in sustainable agriculture. The survey showed good potential for SSF to produce biostimulants and biopesticides useful in agriculture.
Inhibition of Mitochondrial Antioxidant Defense and CDK4/6 in Mesothelioma

Advanced mesothelioma is considered an incurable disease and new treatment strategies are needed. Previous studies have demonstrated that mitochondrial antioxidant defense proteins and the cell cycle may contribute to mesothelioma growth, and that the inhibition of these pathways may be effective against this cancer. We demonstrated that the antioxidant defense inhibitor auranofin and the cyclin-dependent kinase 4/6 inhibitor palbociclib could decrease mesothelioma cell proliferation alone or in combination. In addition, we determined the effects of these compounds on colony growth, cell cycle progression, and the expression of key antioxidant defense and cell cycle proteins. Auranofin and palbociclib were effective in decreasing cell growth and inhibiting the above-described activity across all assays. Further study of this drug combination will elucidate the contribution of these pathways to mesothelioma activity and may reveal a new treatment strategy.
Object-oriented fusion of RADARSAT-2 polarimetric synthetic aperture radar and HJ-1A multispectral data for land-cover classification

Abstract. The contribution of the integration of optical and polarimetric synthetic aperture radar (PolSAR) data to accurate land-cover classification was investigated. For this purpose, an object-oriented classification methodology that consisted of polarimetric decomposition, hybrid feature selection, and a support vector machine (SVM) was proposed. A RADARSAT-2 Fine Quad-Pol image and an HJ-1A CCD2 multispectral image were used as data sources. First, polarimetric decomposition was implemented for the RADARSAT-2 image. Sixty-one polarimetric parameters were extracted using different polarimetric decomposition methods and then merged with the main diagonal elements (T11, T22, T33) of the coherency matrix to form a multichannel image with 64 layers. Second, the HJ-1A and the multichannel images were divided into numerous image objects by implementing multiresolution segmentation. Third, 1104 features were extracted from the HJ-1A and the multichannel images for each image object. Fourth, the hybrid feature selection method that combined the ReliefF filter approach and the genetic algorithm (GA) wrapper approach (ReliefF–GA) was used. Finally, land-cover classification was performed by an SVM classifier on the basis of the selected features. Five other classification methodologies were conducted for comparison to verify the contribution of optical and PolSAR data integration and to test the superiority of the proposed object-oriented classification methodology. Comparison results show that HJ-1A data, RADARSAT-2 data, polarimetric decomposition, ReliefF–GA, and SVM have a significant contribution by improving land-cover classification accuracy.
Mendelian Randomization Analyses of Chronic Immune-Mediated Diseases, Circulating Inflammatory Biomarkers, and Cytokines in Relation to Liver Cancer

Simple Summary Liver cancer is a prevalent gastrointestinal carcinoma and is closely linked to chronic inflammation, including both hepatic and extrahepatic inflammations. However, the genetic association between inflammatory traits and liver cancer has not been systematically investigated. In this study, we aimed to explore the potential causal associations between immune-mediated diseases, circulating inflammatory biomarkers and cytokines, and liver cancer using Mendelian randomization (MR) analysis. To our best knowledge, this is the most comprehensive MR study on this topic to date, involving more than 200 inflammatory traits. This is an important contribution to the field, as it provides insights into the potential causal inflammatory factors of liver cancer. Abstract Liver cancer is closely linked to chronic inflammation. While observational studies have reported positive associations between extrahepatic immune-mediated diseases and systemic inflammatory biomarkers and liver cancer, the genetic association between these inflammatory traits and liver cancer remains elusive and merits further investigation. We conducted a two-sample Mendelian randomization (MR) analysis, using inflammatory traits as exposures and liver cancer as the outcome. The genetic summary data of both exposures and outcome were retrieved from previous genome-wide association studies (GWAS). Four MR methods, including inverse-variance-weighted (IVW), MR-Egger regression, weighted-median, and weighted-mode methods, were employed to examine the genetic association between inflammatory traits and liver cancer. Nine extrahepatic immune-mediated diseases, seven circulating inflammatory biomarkers, and 187 inflammatory cytokines were analyzed in this study. The IVW method suggested that none of the nine immune-mediated diseases were associated with the risk of liver cancer, with odds ratios of 1.08 (95% CI 0.87–1.35) for asthma, 0.98 (95% CI 0.91–1.06) for rheumatoid arthritis, 1.01 (95% CI 0.96–1.07) for type 1 diabetes, 1.01 (95% CI 0.98–1.03) for psoriasis, 0.98 (95% CI 0.89–1.08) for Crohn’s disease, 1.02 (95% CI 0.91–1.13) for ulcerative colitis, 0.91 (95% CI 0.74–1.11) for celiac disease, 0.93 (95% CI 0.84–1.05) for multiple sclerosis, and 1.05 (95% CI 0.97–1.13) for systemic lupus erythematosus. Similarly, no significant association was found between circulating inflammatory biomarkers and cytokines and liver cancer after correcting for multiple testing. The findings were consistent across all four MR methods used in this study. Our findings do not support a genetic association between extrahepatic inflammatory traits and liver cancer. However, larger-scale GWAS summary data and more genetic instruments are needed to confirm these findings.
A GNSS-aided DVL calibration method based on quaternion estimation for underwater vehicles

Abstract Doppler velocity logger (DVL) error parameters can significantly influence the navigation accuracy of DVL/strapdown inertial navigation system (SINS) integration for unmanned underwater vehicles (UUV). To improve the navigation accuracy of UUV, this study proposes a two-stage DVL calibration method aided by global navigation satellite system (GNSS) measurements. First, utilizing the velocity of GNSS/SINS integrated navigation, the scale factor error of DVL is calculated by the moduli of velocities in UUV body frame and DVL instrument frame. Then, using the measurements throughout the calibration process, the calibration problem of the installation angle is converted to a nonlinear constraint optimization problem by describing the angle as a unit quaternion. Moreover, an easy-to-implement quaternion estimation algorithm is chosen to solve the problem and obtain the optimal quaternion. Simulation and sea trial indicate that the proposed method can rapidly and accurately estimate the DVL error parameters in different scenarios, and the position accuracy of the DVL/SINS system is improved.
Analysis of the Correlation between Mass-Media Publication Activity and COVID-19 Epidemiological Situation in Early 2022

The paper presents the results of a correlation analysis between the information trends in the electronic media of Kazakhstan and indicators of the epidemiological situation of COVID-19 according to the World Health Organization (WHO). The developed method is based on topic modeling and some other methods of processing natural language texts. The method allows for calculating the correlations between media topics, moods, the results of full-text search queries, and objective WHO data. The analysis of the results shows how the attitudes of society towards the problems of COVID-19 changed from 2021–2022. Firstly, the results reflect a steady trend of decreasing interest of electronic media in the topic of the pandemic, although to an unequal extent for different thematic groups. Secondly, there has been a tendency to shift the focus of attention to more pragmatic issues, such as remote learning problems, remote work, the impact of quarantine restrictions on the economy, etc.
Disentangling the Pathogenesis of Systemic Lupus Erythematosus: Close Ties between Immunological, Genetic and Environmental Factors

Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease that attacks various organ systems with a variety of clinical implications, ranging from mild skin and mucosal manifestations to severe central nervous system manifestations and death. Cases of SLE have been documented nearly two centuries ago when scholars used the terms ‘erythema centrifugum’ and ‘seborrhea congestiva’ to describe the discoid skin lesions and the butterfly or malar rash in SLE. Since then, knowledge about this disease has developed rapidly, especially knowledge related to the underlying pathogenesis of SLE. To date, it is known that immune system dysregulation, supported by genetic and environmental predisposition, can trigger the occurrence of SLE in a group of susceptible individuals. Various inflammatory mediators, cytokines and chemokines, as well as intra- and intercellular signaling pathways, are involved in the pathogenesis of SLE. In this review, we will discuss the molecular and cellular aspects of SLE pathogenesis, with a focus on how the immune system, genetics and the environment interact and trigger the various clinical manifestations of SLE.
Electrochemical Sensing of Dopamine Using Polypyrrole/Molybdenum Oxide Bilayer-Modified ITO Electrode

The electrochemical sensing of biomarkers has attracted more and more attention due to the advantages of electrochemical biosensors, including their ease of use, excellent accuracy, and small analyte volumes. Thus, the electrochemical sensing of biomarkers has a potential application in early disease diagnosis diagnosis. Dopamine neurotransmitters have a vital role in the transmission of nerve impulses. Here, the fabrication of a polypyrrole/molybdenum dioxide nanoparticle (MoO3 NP)-modified ITO electrode based on a hydrothermal technique followed by electrochemical polymerization is reported. Several techniques were used to investigate the developed electrode’s structure, morphology, and physical characteristics, including SEM, FTIR, EDX, N2 adsorption, and Raman spectroscopy. The results imply the formation of tiny MoO3 NPs with an average diameter of 29.01 nm. The developed electrode was used to determine low concentrations of dopamine neurotransmitters based on cyclic voltammetry and square wave voltammetry techniques. Furthermore, the developed electrode was used for monitoring dopamine in a human serum sample. The LOD for detecting dopamine by using MoO3 NPs/ITO electrodes based on the SWV technique was around 2.2 nmol L−1.
Analysis of LVADs in a controlled mock systemic circulation

Introduction LVADs are more and more used as bridge to recovery or destination therapy rather than bridge to transplant. For these applications, the tuning and control of the device is critical with respect to the outcome of the therapy. To evaluate LVADs under different circumstances, a mock circulation system, featuring at least the Frank-Starling mechanism of the heart, may be helpful. In this study, we developed a mock systemic circulation with a Hill-type heart contraction model. This contraction model performs better in describing the heart function in combination with a pump than the widely used elastance-based models (2). A further enhancement is the baroreflex heart rate control mechanism.