Miracle-dz/UniFAR-FTUs huggingface dataset:
(cid:1) -Adrenergic Enhancement of Sarcoplasmic Reticulum Calcium Leak in Cardiac Myocytes Is Mediated by Calcium/Calmodulin-Dependent Protein Kinase

—Enhanced cardiac diastolic Ca leak from the sarcoplasmic reticulum (SR) ryanodine receptor may reduce SR Ca content and contribute to arrhythmogenesis. We tested whether (cid:1) -adrenergic receptor ( (cid:1) -AR) agonists increased SR Ca leak in intact rabbit ventricular myocytes and whether this depends on protein kinase A or Ca/calmodulin-dependent protein kinase II (CaMKII) activity. SR Ca leak was assessed by acute block of the ryanodine receptor by tetracaine and assessment of the consequent shift of Ca from cytosol to SR (measured at various SR Ca loads induced by varying frequency). Cytosolic [Ca] ([Ca] i ) and SR Ca load ([Ca] SRT ) were assessed using fluo-4. (cid:1) -AR activation by isoproterenol dramatically increased SR Ca leak. However, this effect was not inhibited by blocking protein kinase A by H-89, despite the expected reversal of the isoproterenol-induced enhancement of Ca transient amplitude and [Ca] i decline rate. In contrast, inhibitors of CaMKII, KN-93, or autocamtide-2–related inhibitory peptide II or (cid:1) -AR blockade reversed the isoproterenol-induced enhancement of SR Ca leak, and CaMKII inhibition could even reduce leak below control levels. Forskolin, which bypasses the (cid:1) -AR in activating adenylate cyclase and protein kinase A, did not increase SR Ca leak, despite robust enhancement of Ca transient amplitude and [Ca] i decline rate. The results suggest that (cid:1) -AR stimulation enhances diastolic SR Ca leak in a manner that is (1) CaMKII dependent, (2) not protein kinase A dependent, and 3) not dependent on bulk [Ca] i . ( Circ Res . 2007;100:391-398.) m [Ca] the half maximum rate, and is the Hill the NCX and the SR Ca pump, respectively. V m(SRP) was set to 0 for the caffeine-dependent [Ca] T decline (i.e. when the SR Ca pump has no effect upon the decline in [Ca] The fitted parameters are used to calculate the integrated transport rate and the integrated transport during a average decline under the indicated conditions. V m(NCX) , K m(NCX) and H NCX obtained during a caffeine-induced Ca transient were held constant for a cell SR parameters during analysis of twitch Ca
A FRAMEWORK AND ALGORITHMS FOR ENERGY EFFICIENT CONTAINER CONSOLIDATION IN CLOUD DATA CENTERS

: Now a day’s utilization of power in cloud data centers is very large. Minimization of power consumption in data centers is major challenge. Cloud computing uses a network of remote servers which are hosted on the Internet to process, manage, and store data rather than a local server. Containers in cloud is nothing but an image which is a lightweight, software package which executes independently which hold everything you need to run: code, system libraries, system tools, settings. Using container consolidation, containers are migrated to number of hosts. In Container overbooking, allocate some percentage of workload to any resources. In this scenario hosts having CPU utilization and power consumption less than 70% or more than 80% are considered as underloaded or overloaded. In this paper, focus is on the performance of two algorithms named container overbooking and initial placement of containers and compare the results with scheduling algorithms named FirstFit, MostFull, Random and LeastFull. We will combine the both algorithm and create the algorithm which improves the results with reduced the power consumption in data center and resource utilization.
Learning Optimal Sampling Policies for Sketching of Huge Data Matrices

This study presents methods called TSGPR-and SAC-SketchyCoreSVD to improve the protocol of subsampling data ﬁbers for building random sketches and low rank SVD of a data matrix by formulating them as a sequential decision making problem. An agent progressively decides which data ﬁbers to subsample next to maximize the accuracy of low rank SVD under the limited computational resources. Using the information coming from the partially observed data matrix constructed by subsampled ﬁbers so far, methods learn the optimal policy. Thompson sampling and Gaussian process regression are used for TSGPR-SketchyCoreSVD, and Soft Actor-Critic is applied to SAC-SketchyCoreSVD. Experiments show TSGPR-SketchyCoreSVD actively learns the subsampling policy and produces higher accuracy than the original SketchyCoreSVD. SAC-SketchyCoreSVD is still developing, but its intermediate result also shows promising results. This study can be easily expanded to higher order data tensors.
Field test analysis of concentrator photovoltaic system focusing on average photon energy and temperature

The concentrator photovoltaic (CPV) system is unique and different from the common flat-plate PV system. It uses a multi-junction solar cell and a Fresnel lens to concentrate direct solar radiation onto the cell while tracking the sun throughout the day. The cell efficiency could reach over 40% under high concentration ratio. In this study, we analyzed a one year set of environmental condition data of the University of Miyazaki, Japan, where the CPV system was installed. Performance ratio (PR) was discussed to describe the system’s performance. Meanwhile, the average photon energy (APE) was used to describe the spectrum distribution at the site where the CPV system was installed. A circuit simulator network was used to simulate the CPV system electrical characteristics under various environmental conditions. As for the result, we found that the PR of the CPV systems depends on the APE level rather than the cell temperature.
Paralelismo sintáctico-semántico para el tratamiento de elementos extrapuestos en textos no restringidos

En este articulo presentamos un metodo basado en la teoria del paralelismo para la identificacion y resolucion de elementos extrapuestos en textos no restringidos. Esta teoria de paralelismo esta basada en (Palomar 96) y se amplia con el desarrollo de tecnicas de analisis parcial -en las que se estudia las partes relevantes del texto- que facilitan la resolucion de los fenomenos linguisticos. Nos basaremos en los programas Datalog extendidos (Dahl 94) (Dahl 95) como herramienta para la definicion e implementacion de gramaticas. Estas no estan basadas en reglas gramaticales sino en la deteccion de informacion relevante, relajando el proceso y ampliando el conjunto potencial de textos analizables.
Inconsistency and incompleteness in relational databases and logic programs

The aim of this thesis is to study the role played by negation in databases and to develop data models that can handle inconsistent and incomplete information. We develop models that also allow incompleteness through disjunctive information under both the CWA and the OWA in relational databases. In the area of logic programming, extended logic programs allow explicit representation of negative information. As a result, a number of extended logic programs have an inconsistent semantics. We present a translation of extended logic programs to normal logic programs that is more tolerant to inconsistencies. Extended logic programs have also been used widely in order to compute the repairs of an inconsistent database. We present some preliminary ideas on how source information can be incorporated into the repair program in order to produce a subset of the set of all repairs based on a preference for certain sources over others. INDEX WORDS: Incompleteness, Inconsistency, Logic programming, Negation, Nonmonotonic reasoning
THE COLOGNE DATABASE FOR MOLECULAR SPECTROSCOPY, CDMS, IN TIMES OF HERSCHEL, SOFIA, AND ALMA

H. \,S. \,P. Muller, S. Thorwirth, D. \,A. Roth, G. Winnewisser, {\it Astron. Astrophys.H. \,S. \,P. Muller, F. Schloder, J. Stutzki, G. Winnewisser, {\it J. Mol. Struct.web-page: http://www.astro. uni-koeln.de/cdms/.
T HE E FFECT OF L OCAL F ORCING ON A NOMALOUSLY H IGH R AINFALL DURING D RY S EASON IN J AVA , I NDONESIA 印度尼西

During the dry season (May to October) in Java, Indonesia, anomalously high rainfall is investigated using 37-year rainfall data from the Climate Hazards Group InfraRed Precipitation with Station data. The analysis focuses on the years having high rainfall during the dry season between 1982 and 2019. It is conducted using a combination of the presence and absence of La Niña, negative Indian Ocean Dipole Mode events, and other atmospheric/oceanic parameters, such as 2-m temperature, sea surface temperature, outgoing longwave radiation, 200 mb and 850 mb wind. The results show that the presence of both La Niña and negative Indian Ocean Dipole Mode events contributes around 39% to the high rainfall during the dry season, the presence of negative Indian Ocean Dipole Mode - 22%, the absence of both events - 22%, and the presence of La Niña - 17%. The dynamics of monsoon circulation anomaly (200 mb and 850 mb) in the southern Indian Ocean off the coast of Sumatra and Java also plays a role in the increased rainfall during the dry season in Java. This anomaly occurs due to a vortex in the southern equatorial Indian Ocean around 10 ⁰ S, triggering the formation of double Inter-tropical Convergence Zones over the area north of the equator and the southern waters of Java. The increase in rainfall due to this local factor reaches a maximum and extends in June and October, which is associated with the strengthening of circulation anomalies in southern Java, both spatially and vertically (850 and 200 mb).
Predictor of Combined T Cell Pathogenesis in the CD4/CD8 Ratio as a Suitable Laboratory Multiparametric Bioinformatics Distinguish

HIV disease progression is characterized by numerous pathological changes of the cellular immune system. Still, the CD4 cell count and viral load represent the laboratory parameters that are most commonly used in the clinic to determine the disease progression. In this study, we conducted an interdisciplinary investigation to determine which laboratory parameters (viral load, CD4 count, CD8 count, CD4 %, CD8 %, CD4/CD8) are most strongly associated with pathological changes of the immune system. Multiparametric ﬂow cytometry was used to assess markers of CD4 + and CD8 + T cell activation (CD38, HLA-DR), exhaustion (PD-1, Tim-3), senescence (CD28, CD57), and memory differentiation (CD45RO, CD27) in a cohort of 47 untreated HIV-infected individuals. Using bioinformatical methods, we identiﬁed 139 unique populations, representing the “combined T cell pathogenesis,” which signiﬁcantly differed between the HIV-infected individuals and healthy control subjects. CD38, HLA-DR, and PD-1 were partic-ularly expressed within these unique T cell populations. The CD4/CD8 ratio was correlated with more pathological T cell populations ( n = 10) and had a signiﬁcantly higher average correlation coefﬁcient than any other laboratory parameters. We also reduced the dimensionalities of the 139-unique populations by Z-transformations and principal component analysis, which still identiﬁed the CD4/CD8 ratio as the preeminent surrogate of combined T cell pathogenesis. Importantly, the CD4/CD8 ratio at baseline was shown to be signiﬁcantly associated with CD4 recovery 2 y after therapy initiation. These results indicate that the CD4/CD8 ratio would be a suitable
A Novel Host-Parasite Lipid Cross-talk SCHISTOSOMAL LYSO-PHOSPHATIDYLSERINE ACTIVATES TOLL-LIKE RECEPTOR 2 AND AFFECTS IMMUNE POLARIZATION*

Schistosome infections are characterized by prominent T cell hyporesponsiveness during the chronic stage of infection. We found that schistosome-specific phosphatidylserine (PS) activated TLR2 and affected dendritic cells such that mature dendritic cells gained the ability to induce the development of IL-10-producing regulatory T cells. Using mass spectrometry, schistosomal lysophosphatidylserine (lyso-PS) was identified as the TLR2-activating molecule. This activity appears to be a unique property of schistosomal lyso-PS, containing specific acyl chains, because neither a synthetic lyso-PS (16:0) me-diate Th2 development, cell-cell contact is required for T reg cell induction.
Quantum-Chemical Description of the Propensity of Amino Acids of Formation of the Peptide Bond

With purpose of quantitative description of peptide bond formation the bond orders (P CO and P NH ), the bond lengths (RCO and RNH), the charges on the carbon and nitrogen atoms (q C and q N ) of carbonyl and amino groups, the activation energy (∆E#) and the reaction Energy (∆E) for 400 amino acid pairs by use the quantum - chemical method of Density Functional Theory (DFT) have been calculated. The formula of propensity of amino acids of peptide bonds formation (KP) by means these values were constructed.
The Relationship between Iranian Upper-Intermediate EFL Learners’ Contrastive Lexical Competence and Their Use of Vocabulary Learning Strategies

Regarding the vital role of lexical competence as an important requisite for the attainment of full mastery of the four language skills, this study tried to investigate the relationship between Iranian EFL learners’ contrastive lexical competence and their use of vocabulary learning strategies. To fulfil this objective, 60 Iranian upper-intermediate male and female language learners were selected based on the results of an Oxford Quick Placement Test (OQPT). Afterwards, the researcher administered the Contrastive Lexical Competence Test (Ziafar, 2017). After carrying out the CLC test, the participants answered the Questionnaire of Vocabulary Learning Strategies. The questionnaire adapted from the taxonomy of vocabulary learning strategies (VLS) developed by Schmitt (1997). After analyzing the data, it was revealed that determination strategies were the most frequently-used strategies of the five vocabulary learning strategies, followed by cognitive strategies. Moreover, the result indicated that the relationship between CLC and vocabulary learning strategies was a strong positive one and this relationship was of statistical significance. The implications of this study can make teachers aware of the importance of choosing an appropriate strategy of vocabulary learning for language learners to pave the way of improving lexical knowledge for them.
Evaluation of Ceftaroline (CPT) Activity Against Heteroresistant Vancomycin 1 Intermediate Staphylococcus aureus (hVISA) and VISA Methicillin-Resistant S. 2 aureus (MRSA) Strains in an In Vitro Pharmacokinetic/Pharmacodynamic (PK/PD) 3 Model: Exploring the “Seesaw Effect”

27 Background: A “seesaw effect” in MRSA has been demonstrated, whereby 28 susceptibility to beta-lactam antimicrobials increases as glyco- and lipopeptide 29 susceptibility decreases. We investigated this effect by evaluating the activity of the anti- 30 MRSA cephalosporin, ceftaroline, against isogenic strain pairs of MRSA with varying 31 susceptibilities to vancomycin in an in vitro PK/PD model. Methods: The activities of 32 ceftaroline 600mg q12h (targeted f Cmax, 15.2 µg/mL, t 1/2 2.3h) and vancomycin 1g q12h 33 (targeted f Cmax, 18 µg/mL, t 1/2 6h) were evaluated against 3 isogenic, clinical strain pairs 34 of MRSA which developed increased MICs to vancomycin in patients while on therapy, 35 in a 2-compartment hollow-fiber PK/PD model with a starting inoculum of ~10 7 CFU/mL 36 over a 96h period. Bacterial killing and resistance development were evaluated. 37 Expression of penicillin-binding proteins (PBPs) 2 and 4 was evaluated by RT-PCR. 38 Results: Achieved pharmacokinetic parameters were 98-119% of targeted values. 39 Ceftaroline and vancomycin were bactericidal against 5/6, and 1/6 strains at 96h 40 respectively. Ceftaroline was more active against the mutant strains than the parent 41 strains, with this difference being statistically significant for 2/3 strain pairs at 96h. PBP2 42 was 4.4x higher in the VISA strain of 1/3 pairs. PBP2 and PBP4 expression was 43 otherwise similar between parent and mutant strains. Conclusions: These data support 44 the “seesaw” hypothesis that ceftaroline, like traditional beta-lactams, is more active 45 against strains that are less susceptible to vancomycin even when the ceftaroline MICs are identical. Further research to explore these unique findings is warranted.
ON THE SIZE OF A RANDOM MAXIMAMAL GRAPH

Let P be a graph property which is preserved by removal of edges. A random maximal P-graph is obtained from n independent vertices by randomly adding edges, at each stage choosing uniformly among edges whose inclusion would not destroy property P, until no further edges can be added. We address the question of the number of edges of a random maximal P-graph for several properties P, in particular the cases of "bipartite" and "triangle-free". A variety of techniques are used to show that the size of the random maximal bipartite graph is quadratic in n but of order only rc 3 / 2 in the triangle-free case. Along the way we obtain a slight improvement in the lower bound of the Ramsey number r(3,<).
The E ﬀ ects of Sodium Percarbonate Generated Free Oxygen on Daphnia —Implications for the Management of Harmful Algal Blooms

: Increasing frequencies and durations of harmful algal blooms are a nuisance in many aquatic ecosystems. This has led to the use of a variety of control methods to prevent their appearance or to disperse them following their establishment. Most of these methods are not selective; consequently, research into alternative selective methods has been ongoing. Reactive oxygen species generated following the addition of hydrogen peroxide have been shown to selectively target the cyanobacterial component of harmful algal blooms in experimental and ﬁeld settings. This study assesses the e ﬀ ects of increasing concentrations of reactive oxygen species from the addition of sodium percarbonate on zooplankton in a small experimental setting using a natural plankton sample. It was found that the genus Daphnia showed moderate sensitivity to sodium percarbonate. Preliminary evidence suggests that the size of an individual may a ﬀ ect the probability of survival, with larger individuals having a lower likelihood of survival. Lower survival rates of large Daphnia were hypothesized to have been caused by higher relative ﬁltration rates of larger individuals. From the zooplankton data obtained, we suggest that a safe concentration of sodium percarbonate for Daphnia individuals would be below 10.0 mg · L − 1 sodium percarbonate (2.8 mg · L − 1 hydrogen peroxide).
Infrared Properties of Cataclysmic Variables in the 2MASS All Sky Data Release

We present results from our analysis of the near-infrared (J, H, and Ks) photometry for all cataclysmic variables from the catalog of Downes et al. (2001) that are detected in the (final) All Sky Data Release from the Two Micron All Sky Survey (2MASS).
Knots with many minimal genus Seifert surfaces

Roberts proved that a family of alternating, arborescent, prime knots each have at least $2^{2n-1}$ distinct minimal genus Seifert surfaces, where $n$ is the genus of the knot in question. We give a subfamily of these knots that have exactly this many minimal genus Seifert surfaces.
The response of a confined gas to a thermal disturbance. I - Slow transients

The response of a perfect gas confined in a slot to a monotonically varying temperature disturbance at the boundaries is considered. On the acoustic-time scale of the slot the solution is described in terms of.a thin expanding conduction boundary layer adjacent to the slot wall and an isentropic core in which a continuous system of acoustic waves propagate. The equations describing the heat transfer process on thelonger conduction-time scale are found to include nonlinear convection and pressure work terms. Strong coupling exists between the induced velocity field arising from thermal expansion of the gas and the variation of thermodynamical variables. A weak acoustic field is found to be propagating in a spatially anisotropic system varying slowly in time. Solutions are developed by a variety of perturbation methods based on a small parameter which is the ratio of the acoustic to conduction time in the system.
Tunable Upconversion Luminescence and Energy Transfer Process in BaLa2ZnO5:Er3+/Yb3+ Phosphors

BaLa2ZnO5:Er3+/Yb3+ has been synthesized via a high temperature solid-state method, and the tunable upconversion luminescence and energy transfer process between Yb3+ and Er3+ in this system have been demonstrated. Upon 980 nm laser excitation, the intense green and red emission around 527, 553, and 664 nm were observed for BaLa2ZnO5:Er3+/Yb3+, which can be assigned to the characteristic energy level transitions of 2H11/2 → 4I15/2, 4S3/2 → 4I15/2, and 4F9/2 → 4I15/2 of Er3+, respectively. The critical Er3+ quenching concentration (QC) was determined to be about 5 mol%, and the power studies indicated that mixture of 2- and 3-photon process was responsible for the green and red upconversion luminescence.
Quality Evaluation of Apis laboriosa and Apis mellifera Honey Collected from Bagmati Province, Nepal

Honey is a natural sweet substance produced by Apis sp. from floral nectar or other plant parts which are gathered, modified and stored in the honeycombs by honeybees. The current research was aimed to analyze the quality parameters of locally available honey. Honey samples of Apis laboriosa and Apis mellifera were collected during spring of 2019 & 2021 and autumn 2021 from the Bagmati province, Nepal. Samples were analyzed their physicochemical and phytochemical properties. The result shows that, the pH was ranged between [4.467 0.0306 - 5.05 0.02], rheological studies showed Newtonian flow and pseudo-plastic type of Non-Newtonian flow, specific optical rotation was ranged between [(+) 5.75 0.4684 - (-) 12.71 0.234], specific gravity was ranged between [1.35 0.00017 - 1.409 0.00022], moisture content was ranged between [19.2% - 25%]. Secondary Metabolite screening showed the honey samples possesses flavonoids, saponins, glycosides, tannins, amino acids, protein and reducing sugar. Total phenolic content was ranged between [1.0427 - 6.86288] gm GAE/Kg honey while total flavonoid content ranged between [0.016755 - 0.353132] gm QE/Kg Honey. IC50 obtained from DPPH assay ranged between [649.6465 - 9867.1617] ppm. Properties and qualities of honey are affected by seasonal factors and various floral sources. The samples were in positive correlation between flavanoid content, phenolic content and their respective anti-oxidant potency.
A Review on Recent Advances of Cerebral Palsy

This narrative review summarizes the latest advances in cerebral palsy and identifies where more research is required. Several studies on cerebral palsy were analyzed to generate a general idea of the prevalence of, risk factors associated with, and classification of cerebral palsy (CP). Different classification systems used for the classification of CP on a functional basis were also analyzed. Diagnosis systems used along with the prevention techniques were discussed. State-of-the-art treatment strategies for CP were also analyzed. Statistical distribution was performed based on the selected studies. Prevalence was found to be 2-3/1000 lives; the factors that can be correlated are gestational age and birth weight. The risk factors identified were preconception, prenatal, perinatal, and postnatal categories. According to the evidence, CP is classified into spastic (80%), dyskinetic (15%), and ataxic (5%) forms. Diagnosis approaches were based on clinical investigation and neurological examinations that include magnetic resonance imaging (MRI), biomarkers, and cranial ultrasound. The treatment procedures found were medical and surgical interventions, physiotherapy, occupational therapy, umbilical milking, nanomedicine, and stem cell therapy. Technological advancements in CP were also discussed. CP is the most common neuromotor disability with a prevalence of 2-3/1000 lives. The highest contributing risk factor is prematurity and being underweight. Several preventions and diagnostic techniques like MRI and ultrasound were being used. Treatment like cord blood treatment nanomedicine and stem cell therapy needs to be investigated further in the future to apply in clinical practice. Future studies are indicated in the context of technological advancements among cerebral palsy children.