Miracle-dz/UniFAR-FTUs huggingface dataset:
Melatonin Rescues Dimethoate Exposure-Induced Meiotic and Developmental Defects of Porcine Oocytes

Simple Summary Environmental pollution poses concerns for public health. Dimethoate is a pesticide widely used in agricultural fields and home gardens. Recent studies have shown that dimethoate exposure impaired reproductive functions in male and female animals. However, whether dimethoate exposure affects oocyte maturation and how to reduce the toxicity of dimethoate remain unclear. Here, we showed that dimethoate exposure impaired nuclear and cytoplasmic maturation of porcine oocytes. Melatonin supplementation restored the meiotic maturation of dimethoate-exposed oocytes by suppressing the generation of excessive reactive oxygen species and autophagy and DNA damage accumulation. Therefore, melatonin counteracts the toxic effects of dimethoate exposure on porcine oocyte maturation. These findings imply that melatonin could be a promising agent in improving the quality of dimethoate-exposed oocytes from humans and animals. Abstract Dimethoate (DT) is an environmental pollutant widely used in agricultural fields and home gardens. Studies have shown that exposure to DT causes reproductive defects in both male and female animals. However, the effects of DT exposure on oocyte maturation and the approach to counteract it are not yet known. Here, we investigated the toxicity of DT on porcine oocyte maturation and the protective effects of melatonin (MT) on DT-exposed oocytes. DT exposure with 1.5 mM partially inhibited cumulus cell expansion and significantly reduced the rate of first polar body extrusion (pb1) during oocyte maturation. Parthenogenetically activated embryos derived from DT-exposed oocytes could not develop to the 2-cell and blastocyst stage. Furthermore, DT exposure led to a significant increase in the rates of misaligned chromosomes, disorganized spindles, and abnormal actin assembly. DT exposure severely disrupted the distribution patterns of mitochondria in oocytes but did not change the subcellular localizations of cortical granules. Importantly, MT supplementation rescued the meiotic and developmental defects of DT-exposed oocytes through repressing the generation of excessive reactive oxygen species (ROS) and autophagy, and DNA damage accumulation. These results demonstrate that melatonin protects against meiotic defects induced by DT during porcine oocyte maturation.
On the Construction of an Edge-Based Remote Sensing Framework: The Applications on Automated Guided Vehicles and Drones

To monitor the status and mission progress of automated guided vehicles (AGVs), most platforms typically obtained real-time data through a data acquisition system that is deployed on the end vehicles. The data acquired from an end vehicle are generally sparse but are required frequently, and an examination process using cloud storage cannot commence until the device’s raw data are received. To reduce communication costs, the proposed edge-based monitoring system (EMS) applies edge computation to move the data examination from the cloud to an end site. The data buffered in the end device could be pre-processed by some detectors. For example, checking the energy is adequate for returning to the base. Thus, buffering data on the end device helps to minimize the time required by the decision maker for abnormal events, e.g., shutdowns caused by exhausted energy. In addition to adopting the common methods of storing, processing, and analyzing data at the data center, the EMS moves some time-sensitive services to the end vehicle. Moreover, after obtaining real-time motion data, the edge computing architecture immediately targets abnormal actions and sends reaction commands to shorten the decision making delay caused by the communication cost between the end vehicles and cloud storage sites, thereby avoiding collisions or accidents. The EMS has been implemented to monitor AGV and unmanned aerial vehicles. The EMS primarily monitored the power and motion of the vehicles. It also combined task-oriented motion commands for monitoring unexpected vehicle motions during tasks. If an abnormal event occurred, immediate warnings were provided through a notification interface and were immediately processed by the EMS to ensure safety during task execution. After checking data consistency between the EMS and the real device, the EMS reveals the corrected status of the device with very little delay. Therefore, the EMS could help with minimizing the time taken to make decisions. Moreover, the EMS has been modified to be deployed on drones to confirm its cross-platform applicability. In the simulations of drones, the EMS also got similar results to the simulations of AGVs. Therefore, the EMS could reduce the time in examining abnormal events and has cross-platform functionality.
Dolor de rebote en anestesia regional: Una revisión narrativa

Objectives: To describe the phenomenon of rebound pain associated with peripheral nerve blocks in the setting of trauma and orthopedic surgery, to know its characteristics, pathophysiological mechanisms, risk factors, preventive and treatment measures. Methodology: Non-systematic bibliographic review of articles in English, in medical databases PubMed, Google Scholar, Embase, Epistemonikos and Cochrane library in January 2021, restricting the search to articles published in the last five years. A total of 58 articles related to rebound pain in the context of orthopedic and trauma surgery were identified according to the inclusion and exclusion criteria. Results: It was evidenced that there is still no consensus on its definition, although it presents repeated characteristics, such as acute and transitory pain, which occurs after the resolution of the peripheral nerve block. An incidence of up to 50% is described in the outpatient setting, but there is no data outside this setting. Its pathophysiology is complex and not yet fully understood, however, a peripheral sensitization component could determine a higher incidence of the phenomenon. Recognized risk factors correspond to trauma and orthopedic surgeries of the upper limb with dense peripheral nerve blocks and young female patients. In relation to its prevention, dexamethasone and dexmedetomidine stand out as promising adjuvants that together with a multimodal analgesia scheme can mitigate its appearance. Conclusions: Understanding the impact of rebound pain, its characteristics, risk factors, preventive measures and benefits of multimodal analgesia, is part of a comprehensive clinical practice to avoid the negative consequences of increased use of health resources, as well as to reduce the consumption of opioids and their known adverse effects.
An Impact Assessment of National Health Insurance Scheme (NHIS) On Employees’ Productivity in Adamawa State, Nigeria

This study assessed the impact of the National Health Insurance Scheme (NHIS) on employee productivity. The study utilized data from the Federal College of Education (FCE, Yola) and American University of Nigeria (AUN) using a structured questionnaire. A sample of 200respondents was drawn from the two institutions. Count data models were used to examine the effects of the benefits offered by NHIS on the productivity of workers. The findings from this study reveals that awareness and prevention campaign, drug quality, health treatment and dental care service reduce the probability of a worker falling sick and missing work days. The result shows 61% of workers who are insured have never missed work due to sickness in the last 12 months. The study recommends that, the services offered by the NHIS should be more strengthened and sustained since they are found to be impacting much on workers. Thus, proper monitoring and supervision of the programme are important to ensure that the goal of the scheme is attained. Awareness and prevention campaigns should be conducted at regular intervals to bridge the information asymmetric among individuals. When workers are enlightened and informed about certain diseases, for example, diabetes, blood pressure, cancer, etc. They will be able to take both preventive and curative measures. Health treatment should also be improved at the various healthcare centers enrolled in NHIS scheme to ensure that there is efficiency and effectiveness in the treatment given to the beneficiaries. Keywords: Productivity, Health Insurance, NHIS
Widespread Aseismic Slip Along the Makran Megathrust Triggered by the 2013 Mw 7.7 Balochistan Earthquake

InSAR time series data for the 2014–2021 period reveal up to 20 cm of radar line‐of‐sight displacements in the area of the 2013 Mw 7.7 Balochistan earthquake northwest of the Hoshab Fault in the eastern Makran subduction zone in southwest Pakistan. We show that surface displacements were caused by ∼80 cm of aseismic slip along a 5,500‐km2‐wide subhorizontal patch of the megathrust fault. The corresponding moment is Mw 7.3. The percentage of slip in plate‐perpendicular direction ranges from ∼65% in the northwest to 96% in the southeast. Slip is consistent with shear stress imparted by the 2013 earthquake. The triggered aseismic slip suggests that this section of the megathrust is decoupled. The implication for the seismic potential of the subduction zone is that the megathrust is fully locked to at most 220 km distance from the trench, consistent with the lack of M ≥ 9 earthquakes in the historic record.
SAP Business Intelligence

This book provides you with highly detailed information on all of the most important BI features of the new SAP NetWeaver 2004s Release. Readers gain a profound understanding of SAP BI and quickly learn how to master the new release, while avoiding costly errors. Familiar subjects like data modeling, ETL, web reporting, and planning are combined with expert insights on essential new BI functions and core concepts, making this reference an invaluable companion for your daily work. The authors provide exclusive details on advanced developments in BEx Analyzer and BEx Web Application Designer, as well as the BEx Report Designer, BI-integrated planning, the BI Accelerator and the SAP Visual Composer, ensuring that your most important questions are addressed with practical guidance. Real-life examples, volumes of screen captures and detailed graphics, as well as step-by-step instruction, enable you to quickly and easily familiarize yourself with all of the new BI functions. The book is intended for SAP consultants, team members and managers in the areas of IT, BI, and controlling. Highlights Include: Business Intelligence Concepts New Features of SAP NetWeaver 2004s Data Modeling in the Administrator Workbench Data Retrieval Performance Optimization with Aggregates and BI Accelerator Redesign Functions: Repartitioning and Remodeling BEx Query Designer BEx Analyzer BEx Web Application Designer Report Designer BI Integrated Planning Visual Composer
Linkage of Electricity with Agricultural Growth and Technology Factors: An Illustration of India’s Case

Understanding the relationship between electricity consumption and economic growth is crucial for formulating efficient energy policies for all sectors in general, and for agriculture in particular. To study this, an empirical examination of the long-run co-movement and the causal relationship between electricity consumption and real gross state domestic product (GSDP) from agriculture and its allied sectors is attempted. The agricultural sector involves the use of different input technologies that are further influenced by electricity consumption. To account for this technology-enabling effect of electricity, we further take up an analysis of the relationship between electricity consumption and agricultural technology factors: fertilizer consumption, the share of irrigation, area under cereal, and the extent of mechanization. We use both state (data from 17 states for the period 1993–2017 for the electricity–GSDP relationship) and country-level data (for the period 1980–2018 for the electricity–technology factors relationship) in the analysis. Since short-period time series datasets analysis may yield unreliable and inconsistent results, we employed modern heterogeneous panel co-integration and panel-based error correction model techniques for analyzing the energy–growth linkage. When the heterogeneous states effect is taken into account, the empirical results fully support a positive long-run co-integrated connection between GSDP and electricity consumption. We could detect both long-run and short-run unidirectional causality running from electricity consumption to agricultural growth. Further electricity consumption was also found to augment the use of technology factors in agriculture. This calls for implementing policies and strategies for achieving higher electricity use in agriculture and improved efficiency in its utilization simultaneously.
Outcomes of Patients with Metastatic Melanoma—A Single-Institution Retrospective Analysis

Simple Summary Approximately 15% of patients diagnosed with locally advanced malignant melanoma will relapse. Currently, anti-PD-1 and anti-CTLA4 antibodies and BRAF/MEK inhibitors are the mainstay of treatment of advanced, inoperable or disseminated malignant melanoma. A group of 52 patients treated for disseminated malignant melanoma in 2013–2018 was subjected to a retrospective analysis. Overall survival, time to relapse after surgery, time to first disease progression after first-line treatment and time to second progression after second-line treatment were assessed. Factors such as age of the patients, type of progression, stage, blood parameters and the treatment used were analyzed for their influence on prognosis. The study showed that the BRAF V600 mutation is an independent prognostic factor for the recurrence of malignant melanoma after surgery. Patients with this mutation had a longer progression-free time compared to patients undergoing monotherapy with anti-PD-1/PD-L1 antibodies (p = 0.046). The type of treatment used had no effect on overall survival (Z = 0.23, p > 0.05). Abstract Background: This study assessed risk factors and the results of treatment with anti-PD-1 antibodies and BRAF/MEK inhibitors for advanced malignant melanoma. Methods: A retrospective analysis was performed on 52 patients treated with immunotherapy and BRAF/MEK inhibitors for disseminated malignant melanoma. Results: The median follow-up was 31 months (6–108 months). The median PFS1 was 6 months (1–44 months). Second-line systemic treatment was applied in 27 patients (52%). The median PFS2 was 2 months (0–27 months), and the median OS was 31 months (6–108 months). Among the analyzed risk factors, only the presence of the BRAF mutation was statistically significant for disease recurrence after surgery. In patients undergoing anti-BRAF/MEK therapy, the median PFS1 was 7 months, and in patients undergoing mono-immunotherapy, 4 months. The 12- and 24-month PFS1 rates in the group treated with BRAF inhibitors were 29 and 7%, respectively, and in patients treated with mono-immunotherapy 13 and 0%, respectively (Z = 1.998, p = 0.04). The type of treatment used had no effect on OS (Z = 0.237, p > 0.05). Conclusion: Patients with the V600 mutation should be closely monitored. In the event of disease recurrence, treatment with BRAF/MEK inhibitors should be considered. The type of treatment used has no effect on OS.
Two-Step Geometry Design Method, Numerical Simulations and Experimental Studies of Bioresorbable Stents

The stent-implantation process during angioplasty procedures usually involves clamping the stent onto a catheter to a size that allows delivery to the place inside the artery. Finding the right geometrical form of the stent to ensure good functionality in the open form and to enable the clamping process is one of the key elements in the stent-design process. In the first part of the work, an original two-step procedure for stent-geometry design was proposed. This was due to the necessary selection of a geometry that would provide adequate support to the blood-vessel wall without causing damage to the vessel. Numerical simulations of the crimping and deployment processes were performed to verify the method. At the end of this stage, the optimal stent was selected for further testing. In addition, numerical simulations of selected experimental tests (catheter-crimping process, compression process) were used to verify the obtained geometrical forms. The results of experimental tests on stents produced by the microinjection method are presented. The digital image correlation (DIC) method was used to compare the results of numerical simulation and experimental tests. The two-step modeling approach was found to help select the appropriate geometry of the expanded stent, which is an extremely important step in the design of the crimping process. In the part of the paper where the results obtained by numerical simulation were compared with those gained by experiment and using the DIC method, a good compatibility of the displacement results can be observed. For both longitudinal and transverse (pinch) stent compression, the results practically coincide. The paper presents also the application of the DIC method which significantly expands the research possibilities, allowing for a detailed inspection of the deformation state and, above all, verification of local dangerous areas. This approach significantly increases the possibility of assessing the quality of the stents.
Uso efetivo de flashcards como metodologia de ensino-aprendizagem na disciplina laboratório de ortodontia

Dos diversos ramos da Odontologia, um dos conteúdos considerados de complexa aprendizagem é a Ortodontia. Buscando o reforço da informação e evocá-la com mais facilidade, foi utilizada na monitoria, um serviço de apoio pedagógico, que oportuniza o desenvolvimento de habilidades técnicas e aprofundamento teórico do acadêmico, a estratégia de ensino e aprendizado usando os flashcards que lança mão dos princípios de recordação ativa e repetição espaçada. O objetivo é avaliar a eficácia dos flashcards como método de aprendizado na formação acadêmica e analisar o impacto dessa ferramenta durante o período pandêmico da COVID-19. Este estudo é do tipo descritivo, transversal e quali-quantitativo, cuja amostra foi 42 alunos matriculados na disciplina laboratório de ortodontia, que utilizaram a ferramenta flashcards e que voluntariamente responderam o instrumento de coleta questionário individual online. Os dados coletados foram estratificados e exportados para o software Statistical Packcage for the Social Sciences (SPSS), calculadas as frequências absolutas e percentual, além do valor de alfa de Cronbach para avaliação da validade interna das respostas (p<0.05). Observou-se que 61,9% dos estudantes consideram a ferramenta excelente no processo ensino-aprendizado, 64,3% apontam que a ferramenta contribui de forma excelente para reter conhecimento e 51,2% ficaram satisfeitos com o desempenho obtido através dessa ferramenta na disciplina. O questionário para avaliação dos flashcards apresentou uma ótima consistência interna (α = 0,806). Os flashcards provaram ser um recurso útil para a aprendizagem, especialmente em longo prazo, fornecendo uma tecnologia que pode ser compartilhada entre um grupo de estudantes ou mesmo em um aplicativo digital.
Fiscal Policy Measures and Investment Decisions in Nigeria (1995 – 2019)

This paper examined the extent to which fiscal policy measures could effectively be used to promote investment decision in Nigeria. The data employed covered the period of 1995 to 2019 which include fiscal measures such as capital expenditure, recurrent expenditure, value added tax and investment. In performing the empirical analysis, econometric techniques such as auto regressive distributed lag (ARDL), unit root, Granger Causality test and bound test were applied on the data to produce acceptable results. The results from the analysis revealed that capital expenditure is positive and significant while recurrent expenditure and value added tax are insignificant to investment growth in the economy. Based on our results, we conclude that more priority should be place on capital expenditure in the country for it will stimulate investment growth respectively.
The Volatility of Rupiah Exchange Rate Impact on Main Commodity Exports to the OIC Member States

This study analysed the impact of the volatility of the rupiah exchange rate on four main commodities exported from Indonesia to six member countries of the Organisation of the Islamic Cooperation (OIC) (Saudi Arabia, Malaysia, Pakistan, United Arab Emirates, Turkey, and Bangladesh). The study employed monthly data spanning from January 2007 to December 2019 and the EGARCH method to obtain exchange rate volatility, while the ARDL method was used to model both the short-run and long-run impact of exchange rate and its volatility on exports. In the short term, findings revealed that exchange rate volatility has a significant negative effect on five main commodity exports to OIC countries, whereas, in the long-term, volatility of the exchange rate negatively affects twelve main commodity exports to OIC countries. Our results further imply that most of Indonesia’s exporters to six OIC Member countries are risk-averse.
Psychometric Properties of PSS-10 among Atrial Fibrillation Patients

Objective: The objective of the current study was to assess the psychometric properties of Perceived Stress Scale 10 (PSS-10) among atrial fibrillation (AF) patients. Methodology: A cross-sectional study was performed among AF patients using the PSS-10. Sociodemographic and patients reported clinical data were collected. Descriptive and inferential statistics were applied using the Statistical Package for Social Sciences (SPSS) version 24.0. A p-value < 0.05 was considered statistically significant. Results: There were more male patients (n=165) than the female patients (n=111) in total of 276 studied patients. No major issues regarding internal consistency, factorial validity, convergent validity and floor and ceiling effect were observed. Conclusion: The present study confirmed the psychometric properties validation of PSS-10 among AF patients.
A Photolysis-Assist Molecular Communication for Tumor Biosensing

Molecular communication (MC) is a promising bioinspired paradigm for exchanging molecule information among nanomachines. In this paper, we propose a synchronization-assist photolysis MC system that aims to transmit the biosensing signal of the tumor microenvironment, facilitated by mitigating redundant molecules for improved bit error rate (BER) performance. Benefits from biocompatible MC, biosensors could transmit biosensing signals of the tumor in vivo instead of converting them to electrical signals. Due to diffusion motion’s slow and stochastic nature, intersymbol interference (ISI), resulting from previous symbols’ residual information molecules, inevitably occurs in diffusion-based MC. ISI is one of the challenges in diffusion-based MC, which significantly impacts signal detection. Inspired by on–off keying (OOK) modulation, the proposed modulation implements a switch of molecules and light alternatively. The light emitted is triggered by a synchronization signal, and the photolysis reactions could reduce the redundant molecules. An expression for the relevant channel impulse response (CIR) is derived from a hybrid channel model of diffusion and photolysis reaction. In this paper, we implement the maximum posterior estimation scheme to find the optimal decision threshold and analysis the BER performance in terms of different time intervals of the system. Numerical simulations demonstrate that the proposed method can improve the channel capacity and BER performance. We believe that our work may pave the way for MC application in biosensing.