Miracle-dz/UniFAR-FTUs huggingface dataset:
Breeding of industrial hemp with a high content of cannabigerol by the case of ‘Vik 2020’ cultivar

To create an industrial hemp variety of the Central European ecological and geographical type with a high cannabigerol content and universal application. Methods. Breeding (self-pollination, creation of artificial populations, selection), field, biochemical (thin-layer and gas-liquid chromatography of cannabinoid compounds), instrumental and technological assessment of fibre quality, and statistical methods. Results. Variety ‘Vik 2020’ was obtained as a result of creation of artificial populations. The plants are characterized by higher content of cannabigerol (1.034 ± 0.0323%), and almost zero of other secondary metabolites, such as cannabidivarin, cannabidiol, cannabichromene and psychotropic tetrahydrocannabinol (0.003 ± 0.0011; 0.018 ± 0.0080; 0.012 ± 0.0027, and 0.005 ± 0.0012%, respectively). The t rait of cannabigerol content is quite stable within the population and is not correlated with the trait of tetrahydrocannabinol content (r = -0.23). TLC showed that cannabigerol accumulated mainly in the form of cannabigerolic acid and to a lesser extent as a neutral compound, which is consistent with the theory that this substance is a precursor for the synthesis of other cannabinoids. According to the results of the competitive variety test, when growing to obtain fibre and seeds, the variety features short height, specifically significantly lower total (206.4 cm) and technical stem length (135.6 cm) compared to the standard variety, significantly higher inflorescence length (70.8 cm), which determine the formation of the significant yield of biomass suitable for pharmaceutical use and high seed yield (0.98 t/ha). The yield of total fibre was the same as in the standard variety (29.0%), but its quality and technological value for primary processing were higher. The variety had a homogeneous sex structure, resistance to bioltic and abiotic environmental factors. Plants reached biological maturity in 116 days (BBCH 89). This cultivar is recommended for obtaining seeds, quality fiber and potentially cannabigerol (on condition of changes in legislation). Conclusions. The efficiency of using self-pollinating lines in breeding with their subsequent combining into a synthetic population and improving selection was proved by the case of a new variety of industrial hemp ‘Vik 2020’, characterized by an increased content of cannabigerol and the absence of psychotropic properties
Size Characterization of Glutathione-Protected Gold Nanoclusters in the Solid, Liquid and Gas Phases

Monolayer-protected metal nanoclusters belonging to the size regime between two and a few hundred atoms represent unique building blocks for new materials. Because of the extremely tiny size of such clusters (smaller than ∼3 nm in diameter) and the stabilizing layer which varies in size and composition, traditional techniques used for characterizing the size of large metal nanoparticles are not very reliable. In this work, we compare solid, liquid and gas phase size characterization methods for selected glutathione- (SG-) protected gold clusters (namely Au15(SG)13, Au18(SG)14, and Au25(SG)18). We also investigate the effect of nanocluster ion-pairing with bulky counterions on their size characterization. We show that X-ray powder diffraction, ion mobility mass spectrometry, and time-resolved fluorescence anisotropy can be a useful addition to tools available for ultrasmall nanoparticle characterization.
The Deubiquitin Enzyme USP28 Maintains the Viability of Triple Negative Breast Cancer Cells through Stabilizing the RecQ Family Helicases

Background: Triple-negative breast cancer lacks significant expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. It is the more aggressive and malignant kind of breast cancers and is currently without any effective targeted therapies.Methods: We have screened for genes in the ubiquitin-proteasome system that are essential for the proliferation and survival of TNBC cells via CRISPR/Cas9-mediated gene editing. Growth of TNBC cells were assayed using cell and tumor xenograft models to validate the vital role of USP28. We employed cell biology and biochemical methods to uncover the mechanisms underlying the requirement of USP28 for the proliferation of TNBC cells.Results: USP28, a deubiquitin enzyme, is an essential gene for TNBC cells in vitro and in vivo. Compromising the function of USP28 causes TNBC cells to arrest in S/G2 phases with DNA damage checkpoint activation. We show that RecQ family helicases are regulated by USP28, which is more important in TNBC cells than in other breast cancer cells. We further showed that a small molecule inhibitor of USP28 displayed anti-tumor activities against xenografts derived from TNBC cells.Conclusion: Our data establish a critical role played by USP28 in supporting the proliferation and viability of triple negative breast cancer cells through stabilizing RecQ family helicases and support USP28 as a therapeutic target for TNBC.
Integrated provenance and tectonic implications of the Cretaceous–Palaeocene clastic sequence, Changla Gali, Lesser Himalaya, Pakistan

This study documented the field relationship and integrated provenance of a clastic sequence exposed at the Mesozoic–Cenozoic boundary located in Changla Gali section, Lesser Himalaya, Pakistan, to provide an insight into Cretaceous tectonics of the northern Indian margin. This boundary sequence is represented by the Early Palaeocene Hangu Formation, which consists of shales in the lower part and sandstone in the upper part. The contact relationship of the Early Palaeocene Hangu Formation with the underlying Late Cretaceous Kawagarh Formation is marked by an angular unconformity. The detrital zircons extracted from the shale and sandstone samples shows a major age cluster, which varies between ~700 and ~1,100 Ma (45%), ~1,600 and ~1,900 Ma (15%), and ~480 and ~590 Ma. Additionally, two minor age clusters of the detrital zircons are identified, that is, ~2,300–2,500 Ma and ~600–700 Ma. The younger detrital zircon grains have ages of 298 ± 4 Ma, 297 ± 4 Ma and 116 ± 3 Ma. This age pattern reflect the major source area as the Indian Plate. The two younger Permian zircon grains may be derived from the Panjal mafic volcanic rocks exposed in the vicinity of the study area. However, a single Cretaceous grain may be attributed to ophiolites, as well as Tethyan Himalayan (TH) volcanic rocks. Similarly, the sandstone petrographic results show that the sandstones are quartz‐rich, which show derivation from the craton interior provenance, which is likely the Indian Plate. However, the trace element data suggest a mixed source consisting of felsic and mafic rocks. The contribution of the mafic source is likely associated with the Panjal mafic rocks exposed along the northern Indian margin. The field relationship shows that the underlying Mesozoic sequence is folded prior to the deposition of the Hangu Formation. This folding suggests that the northern Indian margin experienced a regional compression during the Late Cretaceous time, which folded the Mesozoic sequence before the resumption of sedimentation during the Palaeocene. Furthermore, the detrital zircon provenance suggests that the sediments were mainly derived from the Indian Plate. Combining the results, it can be concluded that the compressional event is likely associated with the Late Cretaceous ophiolite obduction onto the leading edge of the Indian Plate. However, the absence of the major ophiolitic age component in the detrital record may suggest that the ophiolites were emplaced over the northern Indian margin but remained submerged during Early Palaeocene time.
Predictors for Retrograde Ureteral Stenting Failure as an Initial Drainage Method for Emergent Complicated Acute Calculus Obstructive Uropathy

Objective: To define predictors for initial retrograde ureteral stenting (RUS) failure with the need for the percutaneous nephrostomy (PCN) insertion as a drainage method in patients with complicated acute calculus obstructive uropathy. Methods: We undertook a retrospective evaluation of patients who presented with complicated obstructive calculus uropathy (acute renal failure or obstructive pyelonephritis) between January 2016 and January 2020. Patients in whom there was failure to visualize ipsilateral ureteric orifice and those with extrinsic ureteral obstruction were excluded. Patient demographics and radiological data including stone site, hydronephrosis grade, maximum transverse stone diameter, periureteral density (PUD) and pericalcular ureteric thickness (P-CUT) at the maximum transverse stone diameter were assessed using non-contrast computed tomography at the time of admission. Results: The study included 256 patients who were managed initially by RUS trial. Of them, 48 (18.8 %) had RUS failure. The presence of acute pyelonephritis, increased maximum transverse stone diameter ≥ 9.5 mm, P-CUT ≥ 7.5 mm, and PUD at stone level ≥ 17.5 HU were risk factors associated with RUS failure (P = 0.007, 0.002, < 0.001, and < 0.001, respectively). Conclusion: Initial radiological stone and ureteric characteristics, in addition to the clinical diagnosis of obstructive pyelonephritis, can be used to determine PCN insertion as the preferred option over RUS for urinary drainage.
A MEMS-CMOS Microsystem for Contact-Less Temperature Measurements

This paper presents a microsystem suitable for contact-less human body temperature measurements, as well as for presence, motion and proximity detection. It consists of a 130-nm CMOS-SOI MEMS (Micro-Electro Mechanical System) thermal sensor, referred to as “TMOS”, and its 130-nm CMOS interface circuit. The TMOS, based on a micromachined transistor, being an active device, features advantages in terms of internal gain: with optimal biasing, indeed, the TMOS achieves 274- $\mu \text{V}/^\circ \text{C}$ input-referred sensitivity at 3-cm distance and 50.33° field-of-view (FOV), outperforming thermopile detectors. The sensor and the interface circuit, featuring a chopper-stabilized-based analog readout with a 12-bit SAR ADC (Successive Approximation Register Analog-to-Digital Converter), were mounted in the same package and extensively measured: the microsystem achieves repeatability and ±0.17°C precision, thus satisfying the requirements for contact-less human body temperature measurements; furthermore, its performance as presence, motion and proximity detector was also verified.
The Phenomenon of Oncology Nurses’ Tendency to Change Duties in Greek Public Hospitals: A Study of Its Causes and Suggestions

Background: The concept of job satisfaction is of great importance regarding its impact on employees’ productivity and efficiency. Especially for oncology nurses has become apparent over the past decades that job satisfaction is a determinant factor not only for the quality of services they provide but also of their tendency to change duties and resign from workplace. While this phenomenon is vastly described by the literature, no survey that investigates nursing personnel’s tendency to resign from workplace has been conducted in Greece. Objectives: To investigate oncology nurses’ job satisfaction while examining the causes of their dissatisfaction in regard to their tendency to change duties, either by departing from the oncology field or by resigning. Material and Method: Using a structured questionnaire, a survey was conducted in four hospitals in the region of Attica that fall within the Greek National Health System, ESY. The research sample comprised 278 oncology nurses, men and women, with varied work experience. The data were analyzed using the SPSS software, applying descriptive statistics, inferential statistics, and Principal Component Analysis. Results: Our findings concerning participants’ job satisfaction were mainly positive. Most of the oncology nurses partaking in the study expressed their willingness to remain in their current workplace, as their placements enable them to diffuse in their tasks the knowledge and experience previously acquired. Conclusion: As oncology nurses’ job satisfaction influences their overall performance and dedication in their profession, parameters as working conditions, equal distribution of the workload, independent decision making and seniors’ management recognition of their work, need to be considered as primarily fields of improvement. With this being the first study in Greece that investigates oncology nurses’ job satisfaction in relation to their tendency to change duties, further research is required for the containment of said phenomenon.
METHODS FOR IMPROVING ALPHA-MANGOSTIN SOLUBILITY: A REVIEW

Solubility is an important parameter to achieve for the bioavailability of a drug to reach the therapeutic windows. Garcinia mangostana Linn is a plant with great potency for the development of natural medicine. Alpha-mangostin is one of the secondary metabolites of G. mangostana and has been reported to have several pharmacological activities. The Biopharmaceutics Classification System (BCS) is a system that classifies drugs based on their solubility and permeability. Due to its low solubility but high permeation, alpha-mangostin is categorized into class II of the Biopharmaceutics Classification System. Therefore, the determination of dosage forms and modification of solubility enhancers is limited due to its physical properties, as mentioned above. This disadvantage requires new methods to improve its solubility to administer alpha-mangostin, especially for oral administration. Here, we discuss the development of the methods to increase alpha-mangostin solubility to be applied to formulate a dosage form to reach a useful plasma level for medication.
Gliding Motion Optimization for a Biomimetic Gliding Robotic Fish

In this article, we present a gliding efficiency optimization strategy based on deep reinforcement learning for a gliding robotic fish. For the gliding motion in shallow waters, the nonsteady motion strongly impacts the gliding range and also reduces efficiency. This article presents a concept of transient gliding motion and illustrates its importance for the gliding robotic fish. For better gliding performance of active fins, several pectoral fins with different sizes are designed and their hydrodynamics and optimizing capabilities are analyzed by computational fluid dynamics simulation. Then, a double deep Q network-based optimization strategy is proposed to improve gliding efficiency by active pectoral fins, in which an adversarial model and a two-stage reward function are presented for the adequate calculation of gliding range. Simulations are conducted to validate the convergence and effectiveness of the proposed strategy. The aquatic experiments are carried out to further verify the proposed strategy. The results reveal that the optimization strategy can save about 4.88% of energy and 19.45% of travel time. This article provides clues to the design of active control surfaces and improvement of gliding efficiency for underwater vehicles. Remarkably, the proposed strategy can significantly improve the duration and endow the robot with the potential to perform complex tasks.
Construcción del rol materno de un hijo con discapacidad:

Resulta imperioso acompañar y brindar soporte a padres de niños con un diagnóstico sugerente de daño físico o mental, a fin de favorecer la ejecución del rol parental de manera efectiva. Por tal motivo, como parte de la línea de Discapacidad de Proyección Social de la Corporación Universidad de Investigación y Desarrollo, se diseñó y aplicó una propuesta de acompañamiento psicológico grupal; partiendo de sus efectos, se realiza un análisis sobre la constitución del vínculo madrehijo y una propuesta metodológica para la sistematización de la experiencia, con el objetivo de comprender los efectos de la intervención y afinar las estrategias utilizadas en el abordaje de esta población. Para el diseño, se tomó en consideración como las características de los vínculos que se establecen en la infancia y el tipo de apego desarrollado con los cuidadores principales influye en la construcción del psiquismo y por ende, servirá de base para la construcción de relaciones durante la adolescencia y adultez. Sin embargo, en ocasiones las dificultades con las que tropiezan los padres podrían deberse a sus propios conflictos para regular su ambivalencia y lidiar con las flaquezas propias de esa etapa del desarrollo, lo cual está dramáticamente expresado al sumarse los duelos de la crianza de un hijo con discapacidad, siendo pertinente acompañarlos en su rol parental, brindando la posibilidad a la construcción subjetiva del mismo. Se presenta una propuesta de intervención en habilidades emocionales para el cuidado de un hijo con discapacidad, un análisis reflexivo de la experiencia tomando como ejes de análisis la subjetividad en la construcción del rol materno, rutinas y diario vivir de las madres de un hijo condiscapacidad y recomendaciones para las intervenciones de madres de niños con discapacidad y los ejes temáticos para la sistematización de la experiencia en futuras aplicaciones con grupos de padres.
Trusting Online Reviews Enhances Intention to Book Online: The Perks of Seeking Information?

Research aims: This study aims to analyze factors affecting consumer intention to book hotels from social media and online travel agencies. Specifically, we examine the direct effects of social media usage and electronic word of mouth (e-WoM) and the indirect effect through the mediation of trust in booking intention.Design/Methodology/Approach: Purposively sampled respondents resulted in 409 responses that met the predefined criteria: aged 18-34, active on their social media accounts, and had accessed online booking sites. Regression with mediating analysis was conducted on valid data.Research findings: Analysis results showed that social media usage and e-WoM had a direct, positive, and significant impact on booking intention. It has also proven to have an indirect effect on consumer booking intention mediated by trust. Social media usage and e-WoM directly affected booking intention and had higher valence when mediated by trust.Theoretical contribution/Originality: Information on social media positively influenced consumer purchase intention on online hotel booking due to its completeness. Further, this study is among the few that applied the e-WOM concept to the hospitality sector.Practitioner/Policy implication: The implication for managers is to improve the online booking management system by increasing promptness in response to reviews, especially the negatives.Research limitation/Implication: This study focused on consumers who have social media accounts and accessed online hotel booking sites, limiting its generalizability.
STRESS TOLERANCE AND ANTIBIOTIC SUSCEPTIBILITY OF CRONOBACTER SPP. ISOLATED FROM POWDERED INFANT FORMULA RETAILED IN NIGERIA

, is an emerging, opportunistic pathogen that causes infections such as , meningitis and in neonates and infants, and can sometimes lead to death. There is zero tolerance for the presence of . all powdered infant formulae because of the high mortality rate (80%) associated with . Three . (CS14, CS17 and CS124) isolated from PIF retailed in Nigeria were exposed to different levels of stress (pH, osmotic, oxidative, heat, bile and desiccation). The production ability of the isolates was investigated and the susceptibility of the isolates to different antibiotics was carried out using the MIC panel. Variation in stress response was observed in the isolates with no consistent pattern. The CS 17 ( ) and CS 124 ( ) showed the highest tolerance to stress on the average. All the isolates exhibited the ability to produce ranging from 1.30 – 2.0 and were also sensitive to more than 95% of the antibiotics used in the MIC panel, with no resistance to any.
ANALISIS TINGKAT KECEMASAN MATEMATIS SISWA SMA

This study aims to give an idea of how the level of mathematical anxiety of high school students. This type of research is descriptive research with qualitative approach. Measurements of student anxiety are seen during the math learning process. The population in this study was 13 high school X graders. The data collection technique uses a mathematical anxiety scale questionnaire containing 23 statements with 3 indicators and analyzed in descriptive statistical form which is then categorized by 4 categories, including high, medium, low, and very low. After the mathematical anxiety level picture was produced, 4 students were selected where each student represented each category to be analyzed in a positive manner the questionnaire answers that had been given. The results showed that no students experienced excessive anxiety levels or in the category of very high anxiety levels, in the very low category it was seen that the number of students who had less mathematical anxiety levels compared to other anxiety level categories was only 1 student, in the category of low mathematical anxiety levels as many as 3 students, 4 students belonged to the category of high anxiety levels or excessive anxiety levels , while the number of students who experience the most levels of anxiety is included in the category of moderate anxiety levels as many as 5 students.
Simulating Historical Earthquakes in Existing Cities for Fostering Design of Resilient and Sustainable Communities: The Ljubljana Case

The seismic exposure of urban areas today is much higher than centuries ago. The 2020 Zagreb earthquake demonstrated that European cities are vulnerable even to moderate earthquakes, a fact that has been known to earthquake-engineering experts for decades. However, alerting decision-makers to the seismic risk issue is very challenging, even when they are aware of historical earthquakes that caused natural catastrophes in the areas of their jurisdiction. To help solve the issue, we introduce a scenario-based risk assessment methodology and demonstrate the consequences of the 1895 Ljubljana earthquake on the existing building stock. We show that a 6.2 magnitude earthquake with an epicentre 5 km north of Ljubljana would cause many deaths and severe damage to the building stock, which would likely lead to direct economic losses higher than 15% of the GDP of the Republic of Slovenia. Such an event would be catastrophic not only for the community directly affected by the earthquake but for the entire country. We have disseminated this information over the course of a year together in addition to formulating a plan for enhancing the community seismic resilience in Slovenia. Hopefully, local decision-makers will act according to their jurisdiction in Slovenia and persuade decision-makers across Europe to update the built environment renovation policy at the European level.