Miracle-dz/UniFAR-FTUs huggingface dataset:
Study on the effect of hgm on the performance of pp/ifr/gf composite packaging materials used in e-commerce logistics

The Hollow Glass Microspheres (HGM) appears in the PP/IFR/GF compound package materials for ecommerce logistics at different doses. How the HGM will change the flame retardance and mechanical properties of these materials, it is the keystone of this study. PP/IFR/GF/HGM as flame-retardant & reinforced package composites for e-commerce logistics are made from substrates Glass Fibre (GF), reinforced nitrogen-phosphorus compound (IFR), flame-retardant polypropylene (PP) composite package material added with a modified HGMs using the Melt-blending. Here is a profound analysis on their behaviors, e.g. combustion, bending, impact, tension strengthens and hardness. The results reveal that a certain amount of HGM additive can somewhat improve the flame retardant and mechanical properties of the composite package materials for e-commerce logistics. As HGM additive increases, the mechanical properties of these package materials get evidently poor. When the dosage of HGM is 10, their mechanical properties are optimal.
Characterization of Cysts using Differential Correlation Coefficient Values from 2D Breast Elastography: Preliminary Study

Though simple cysts are easily identified using sonography, description and management of nonsimple cysts remains uncertain. This study evaluated whether the correlation coefficient differences between breast tissue and lesions, obtained from 2D breast elastography, could potentially distinguish non-simple cysts from cancers and fibroadenomas. We hypothesized that correlation coefficients in cysts would be dramatically lower than surrounding tissue because noise, imaging artifacts, and particulate matter move randomly and decorrelate quickly under compression, compared with solid tissue. For this preliminary study, 18 breast lesions (7 non-simple cysts, 4 cancers, and 7 fibroadenomas) underwent imaging with 2D elastography at 7.5 MHz through a TPX (a polymethyl pentene copolymer) 2.5 mm mammographic paddle. Breasts were compressed similar to mammographic positioning and then further compressed for elastography by 1–7%. Images were correlated using 2D phase-sensitive speckle tracking algorithms and displacement estimates were accumulated. Correlation coefficient means and standard deviations were measured in the lesion and adjacent tissue, and the differential correlation coefficient (DCC) was introduced as the difference between these values normalized to the correlation coefficient of adjacent tissue. Mean DCC values in non-simple cysts were 24.2 ± 11.6%, 5.7 ± 6.3% for fibroadenomas, and 3.8 ± 2.9 % for cancers (p < 0.05). Some of the cysts appeared smaller in DCC images than grayscale images. These encouraging results demonstrate that characterization of non-simple breast cysts may be improved by using DCC values from 2D elastography, which could potentially change management options of these cysts from intervention to imaging follow-up. A dedicated clinical trial to fully assess the efficacy of this technique is recommended.
DECODING THE LIM DEVELOPMENT CODE

During development a vast number of distinct cell types arise from dividing progenitor cells. Concentration gradients of ligands that act via cell surface receptors signal transcriptional regulators that repress and activate particular genes. LIM homeodomain proteins are an important class of transcriptional regulators that direct cell fate. Although in C. elegans only a single LIM homeodomain protein is expressed in a particular cell type, in vertebrates combinations of LIM homeodomain proteins are expressed in cells that determine cell fates. We have investigated the molecular basis of the LIM domain "code" that determines cell fates such as wing formation in Drosophilia and motor neuron formation in chicks. The basic code is a homotetramer of 2 LIM homeodomain proteins bridged by the adaptor protein, nuclear LIM interactor (NLI). A more complex molecular language consisting of a hexamer complex involving NLI and 2 LIM homeodomain proteins, Lhx3 and Isll determines ventral motor neuron formation. The same molecular "words" adopt different meanings depending on the context of expression of other molecular "words. "
SHORT COMMUNICATION Ginsenoside Rh2 Improves Learning and Memory in Mice

A wide range of plant foods and dietary supplements are able to modify the functioning of the central nervous system. In the present study, we observed that oral administration of ginsenoside Rh2 (10 mg/mL) for 3 weeks significantly improved spatial learning and memory. Spatial memory and learning was evaluated in mice by hippocampus-dependent tasks (Morris water maze test) and immunohistochemical marker of cell genesis bromodeoxyuridine. Ginsenoside Rh2 treatment (30 days) promoted cell survival and genesis. Further, ginsenoside Rh2 treatment in enriched condition had no significant effects on cell survival compared with standard condition exposure. These results revealed that ginsenoside Rh2-mediated spatial learning and memory improvement was associated with cell genesis and survival and may be parallel to the mechanism of environmental enrichment. Therefore, ginsenoside Rh2 may have efficacy as a dietary supplement for spatial learning and memory improvement.
Axial Ratio-Tuned Circularly Polarized Square Patch Antenna with Long Stubs

In this letter, we propose a circularly polarized (CP) square antenna that can change the frequency of the minimum axial ratio (AR). The proposed antenna is designed in a very straightforward manner by applying four long stubs to a square patch. The length of one of the stubs is different from that of the other three stubs, and the structural asymmetry is realized in such a manner that the CP characteristic is conveniently obtained. The proposed antenna can independently adjust the resonant frequency and the frequency of the minimum AR value. Therefore, the resonant frequency and the frequency at which the minimum AR value appears can be easily matched. By applying this method, six antennas with the adequate CP characteristic, notwithstanding the varied stub widths (1.5~6.5 mm), are designed.
THE VERHOEFF SYMPOSIUM

THE TREATMENT OF INVASIVE FUNGAL DISEASE OF THE EYE AND ORBITAL structures is a challenging problem which is being encountered with increasing frequency. The increased incidence of these infections is in part attributable to the widespread and prolonged use of corticosteroids and antibiotics administered locally to the eye or systemically. Patients with diabetes, leukemia, Hodgkin's disease, and immunodeficient states (either from their primary disease process or from therapeutic agents) live longer lives and have greater susceptibility to fungal disease especially during critical periods in the course of their illness. The long-term use of indwelling intravenous catheters for the delivery of antibiotics or hyperalimentation to debilitated or postoperative patients is associated with fungemia and metastatic infections of the eye. Fungal septicemia and metastatic fungal endophthalmitis have been reported after the placement of prosthetic cardiac valves. Aside from these modem medical advances which lead to opportunistic fungal invasion, the drug addict using dirty needles has a risk of establishing a focus of fungal infection in the eye. The therapy of disseminated fungal disease as well as disease confined to the eye and orbit has been far from satisfactory. The toxicity and lack of penetrance of traditional antifungal therapy and the resistance of many organisms has led to new developments in the field, which are reported in this paper.
BJRD13484 1..8

Objective: The aim of this study was to develop an improved method for labelling ZHER2:342 with Technetium99m (Tc) using Gly-(D) Ala-Gly-Gly as a chelator and to evaluate the feasibility of its use for visualization of HER2 expression in vivo. Methods: The Affibody® molecule ZHER2:342 was synthesized by Fmoc/tBu solid phase synthesis. The chelator, Gly-(D) Ala-Gly-Gly, was introduced by manual synthesis as the N-terminal extensions of ZHER2:342. ZHER2:342 was labelled with Tc. The labelling efficiency, radiochemical purity and in vitro stability of the labelled molecular probe were analysed by reversed-phase high performance liquid chromatography. Biodistribution and molecular imaging using Tc-peptide-ZHER2:342 were performed. Results: The molecular probe was successfully synthesized and labelled with Tc with the labelling efficiency of 98.106 1.73% (n55). The radiolabelled molecular probe remained highly stable in vitro. The molecular imaging showed high uptake in HER2-expressing SKOV3 xenografts, whereas the MDA-MB-231 xenografts with low HER2 expression were not clearly imaged at any time after the injection of Tc-peptide-ZHER2:342. The predominant clearance pathway for Tc-peptideZHER2:342 was through the kidneys. Conculsion: Tc-peptide-ZHER2:342 using Gly-(D) AlaGly-Gly as a chelator is a promising tracer agent with favourable biodistribution and imaging properties that may be developed as a radiopharmaceutical for the detection of HER2-positive malignant tumours. Advances in knowledge: The Tc-peptide-ZHER2:342 molecular probe is a promising tracer agent, and the results in this study provide a foundation for future development of protocols for earlier visual detection of cancer in the clinical setting.
Shape Analysis and Structuring (Mathematics and Visualization)

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A development of an equilibrium analysis model between electricity retailers under competitive environment

This paper provides a novel equilibrium model for analyzing behaviors of the electric retailers under competitive environment. In the deregulated electricity retail market, the retailers purchase the electricity power and sell it to consumers at the competitive prices. According to their risk attitudes, the retailers optimize the selling prices and the purchase allocation between a day‐ahead market and forward contracts. Without the regulation, an equilibrium by those selfish decision‐making processes of multiple retailers would cause an adverse impact on the electricity market and also the power system. From stable and economical viewpoints, it is important to analyze the unfavorable equilibrium. The selfish behaviors of retailers are modeled as an equilibrium problem with equilibrium constraints in this paper and formulated as a mixed integer linear programming problem to obtain a generalized Nash equilibrium by commercial solvers efficiently. Through computational examples, the proposed model and formulation are validated.
The Training and Field Work Experiences of Community Health Workers conducting non-invasive, population-based screening for Cardiovascular Disease in Four Communities in Low and Middle-Income Settings

Background—Cardiovascular disease (CVD) is on the rise in lowand middle-income countries (LMIC) and is proving difficult to combat due to the emphasis on improving outcomes in maternal and child health and infectious diseases, against a backdrop of severe human resource and infrastructure constraints. Effective task-sharing from physicians or nurses to community health workers (CHWs) to conduct population-based screening for persons at risk, has the potential to mitigate the impact of CVD on vulnerable populations. CHWs in Bangladesh, Guatemala, Mexico, and South Africa were trained to conduct non-invasive population-based screening for persons at high risk for CVD. Objective (s)—The objectives of this study were to quantitatively assess the performance of CHWs during training and to qualitatively capture their training and fieldwork experiences while conducting non-invasive screening for cardiovascular disease (CVD) risk in their communities. Methods—Written tests were used to assess CHWs’ acquisition of content knowledge during training, and focus group discussions conducted to capture their training and fieldwork experiences. Results—Training was effective at increasing the CHWs’ content knowledge of cardiovascular disease (CVD) and this knowledge was largely retained up to six months after the completion of field work. Common themes which need to be addressed when designing task sharing with CHWs in chronic diseases are identified, including language, respect, and compensation. The importance of having intimate knowledge of the community receiving services from design to implementation is underscored. Conclusions—Effective training for screening for CVD in community settings should have a strong didactic core that is supplemented with culture-specific adaptations in the delivery of instruction. The incorporation of expert and intimate knowledge of the communities themselves is critical, from the design to implementation phases of training. Challenges such as role definition, defining career paths, and providing adequate remuneration, must be addressed.
Differential effects of cocaine access and withdrawal on GLT1 expression in rat nucleus accumbens core and shell

Cocaine addiction is characterized by compulsive drug seeking, including relapse after a period of withdrawal. The relapse response requires increased glutamate transmission in the nucleus accumbens (NAc). Consistent with this view, GLT1, the transporter responsible for >90% of glutamate uptake, is down-regulated in NAc after several days of withdrawal in rats previously trained to self-administer cocaine under limited access conditions (1–2 hr/day). Human addiction, however, appears to be better modeled by extending daily drug access (6–8 hr/day) and introducing long periods of withdrawal. Here, we determined the combined effects of manipulating cocaine access and withdrawal on GLT1 expression in NAc core and shell. Rats were trained to self-administer cocaine (0.25 mg per intravenous infusion) in daily limited or extended access sessions for 11 days followed by a period of short (1 day) or long (40–45 days) withdrawal. We found that although cocaine withdrawal decreases GLT1 expression in both core and shell, only in core is GLT1 down-regulation sensitive to both access and withdrawal. In fact, after long withdrawal, GLT1 in core is down-regulated more than in shell in either the limited or extended access condition. Thus, glutamate regulation in core appears to be a critical factor in the drug-seeking behavior that follows relatively long periods of cocaine withdrawal.
Taxonomising and Analysing Small-World Networks

Small-World networks model systems based on a graph or network where some of the edges or links are “shortcuts” linking non local components together and in consequence drastically reducing the mean path-length between arbitrary pairs of nodes in the graph. Networks are said to show the small-world effect if the mean geodesic distance (i.e. the shortest path) scales logarithmically or slower with the network size for fixed degree k [1]. Recent interest in small-world effects in network models has led us to investigate a number of different paradigms for exploring graph or network models. These models are typically formulated in terms of either a regular substrate structure such as a hypercubic mesh and a continuous parameter such as a probability for: adding; rewiring; or damaging links in the graph. We present some results describing bulk and cluster-weighted properties of graphs in each regime. We also review some of the algorithms and techniques for computing these properties and their complexities and scaling features.
Aβ DISRUPTED SYNAPTIC VESICLE ENDOCYTOSIS IN CULTURED HIPPOCAMPAL NEURONS

Neuronal death leading to gross brain atrophy is commonly seen in Alzheimer’s disease (AD) patients. Yet, it is becoming increasingly apparent that the pathogenesis of AD involves early and more discrete synaptic changes in affected brain areas. However, the molecular mechanisms that underlie such synaptic dysfunction remain largely unknown. Recently, we have identified dynamin 1, a protein that plays a critical role in synaptic vesicle endocytosis, and hence, in the signaling properties of the synapse, as a potential molecular determinant of such dysfunction in AD. In the present study, we analyzed beta-amyloid (Aβ)-induced changes in synaptic vesicle recycling in cultured hippocampal neurons. Our results showed that Aβ, the main component of senile plaques, caused ultrastructural changes indicative of impaired synaptic vesicle endocytosis in cultured hippocampal neurons that have been stimulated by depolarization with high potassium. In addition, Aβ led to the accumulation of amphiphysin in membrane fractions from stimulated hippocampal neurons. Moreover, experiments using FM1-43 showed reduced dye uptake in stimulated hippocampal neurons treated with Aβ when compared to untreated stimulated controls. Similar results were obtained using a dynamin 1 inhibitory peptide suggesting that dynamin 1 depletion caused deficiency in synaptic vesicle recycling not only in Drosophila but also in mammalian neurons. Collectively, these results showed that Aβ caused a disruption of synaptic vesicle endocytosis in cultured hippocampal neurons. Furthermore, we provided evidence suggesting that Aβ-induced dynamin 1 depletion might play an important role in this process.
The Relationship of Coronary Artery Calcium To Coronary Heart Disease Events is Similar in Young and Elderly Participants in The Multi-Ethnic Study of Atherosclerosis: A Secondary Analysis of a Prospective Population-based Cohort

Objective— To evaluate the relationship of coronary artery calcium (CAC) to coronary heart disease (CHD) events among young and elderly individuals. Participants and Methods— This is a secondary analysis of data from a prospective, multi-ethnic, population-based cohort study designed to study subclinical atherosclerosis. A total of 6809 persons aged 45 to 84 years old without known cardiovascular disease at baseline were enrolled from July 2000-September 2002. All participants had CAC scoring performed, and were followed up for a median of 8.5 years. The main outcome measures studied were CHD events, defined as myocardial infarction, definite angina or probable angina followed by revascularization, resuscitated cardiac arrest or death attributable to coronary heart disease. Results— Comparing individuals with CAC=0 to those with CAC > 100, there was an increased incidence of CHD events from 1 to 21/1000 person-years, and 2 to 23/1000 person-years in the 45-54 and 75-84 year old age groups respectively. Compared to CAC=0, CAC 1-100 and CAC >100 impart an increased multi-variable adjusted CHD event risk in both the 45-54 and 75-84 year old age groups [HR (95% CI): 45-54 years old, CAC 1-100: 2.3 (0.9-5.8), CAC>100: 12.4 (5.1-30.0); 75-84 years old, CAC 1-100: 5.4 (1.2-23.8), CAC>100: 12.1 (2.9-50.2)]. Conclusions— Increased CAC imparts an increased CHD risk in younger and elderly individuals, suggesting that once CAC is known chronologic age has less importance. The utility of CAC scoring as a risk-stratification tool extends both to younger and elderly patients. MESA diabetes mellitus, smoking, LDL cholesterol, HDL family history of triglycerides, BMI, anti-hypertensive and lipid-lowering
An Internet of Things-Based Environmental Quality Management System to Supervise the Indoor Laboratory Conditions

Indoor air quality (IAQ) is not only a determinant of occupational health but also influences all indoor human behaviours. In most university establishments, laboratories are also used as classrooms. On one hand, indoor environment quality (IEQ) conditions supervision in laboratories is relevant for experimental activities. On the other hand, it is also crucial to provide a healthy and productive workplace for learning activities. The proliferation of cost-effective sensors and microcontrollers along with the Internet of Things (IoT) architectures enhancements, enables the development of automatic solutions to supervise the Laboratory Environmental Conditions (LEC). This paper aims to present a real-time IEQ-laboratory data collection system-based IoT architecture named iAQ Plus (iAQ+). The iAQ+ incorporates an integrated Web management system along with a smartphone application to provide a historical analysis of the LEC. The iAQ+ collects IAQ index, temperature, relative humidity and barometric pressure. The results obtained are promising, representing a meaningful contribution for IEQ supervision solutions based on IoT. iAQ+ supports push notifications to alert people in a timely way for enhanced living environments and occupational health, as well as a work mode feature, so the user can configure setpoints for laboratory mode and schoolroom mode. Using the iAQ+, it is possible to provide an integrated management of data information of the spatio-temporal variations of LEC parameters which are particularly significant not only for enhanced living environments but also for laboratory experiments.
Quasi-Resonant Voltage Doubler With Snubber Capacitor for Boost Half-Bridge DC–DC Converter in Photovoltaic Micro-Inverter

This paper proposes a quasi-resonant boost half-bridge dc–dc converter with high power conversion efficiency and a wide input voltage range for a photovoltaic micro-inverter. The proposed converter has a combined structure of a boost-integrated half-bridge converter on the primary side of the transformer and a voltage doubler with a snubber capacitor on the secondary side. By using the quasi-resonance techniques, it achieves zero-voltage switching (ZVS) turn-on and low turn-off losses for the switches, as well as ZVS turn-on for the diodes. In addition, the proposed converter has no dc-magnetizing current for the transformer due to the dc-blocking capacitor, and it doubles the voltage gain with half the voltage stress of diodes through the voltage doubler. The effectiveness of the converter was verified with a 300-W prototype with an input voltage range of 13–50 V, an output voltage of 400 V, and a switching frequency of 50 kHz. The experimental results show that the converter had more than 90.0% power conversion efficiency for the output power range of ∼300 W, and its maximum power conversion efficiency was 97.5% for an output power of 160 W.
Characterization of synthetic oligonucleotides containing biologically important modified bases by MALDI-TOF mass spectrometry

Oligonucleotides containing modified bases are commonly used for biochemical and biophysical studies to assess the impact of specific types of structural damage on DNA structure and function. In contrast to the synthesis of oligonucleotides with normal DNA bases, oligonucleotide synthesis with modified bases often requires modified synthetic or deprotection conditions. Furthermore, several modified bases of biological interest are prone to further damage during synthesis and oligonucleotide isolation. In this paper, we describe the application of MALDI-TOF-MS to the characterization of a series of modified synthetic oligonucleotides. The potential for and limits in obtaining high mass accuracy for confirming oligonucleotide composition are discussed. Examination of the isotope cluster is also proposed as a method for confirming oligonucleotide elemental composition. MALDI-TOF-MS analysis of the unpurified reaction mixture can be used to confirm synthetic sequence and to reveal potential problems during synthesis. Analysis during and after purification can yield important information on depurination and base oxidation. It can also reveal unexpected problems that can occur with non-standard synthesis, deprotection or purification strategies. Proper characterization of modified oligonucleotides is essential for the correct interpretation of experiments performed with these substrates, and MALDI-TOF-MS analysis provides a simple yet extensive method of characterization that can be used at multiple stages of oligonucleotide production and utilization.