Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognostic Significance of the Systemic Immune-Inflammation Index (SII) in Patients With Small Cell Lung Cancer: A Meta-Analysis

Background Previous studies have investigated the prognostic value of the systemic immune-inflammation index (SII) in small cell lung cancer (SCLC). However, the results have been inconsistent. The study aimed to investigate the prognostic and clinicopathological significance of SII in SCLC through a meta-analysis. Methods The PubMed, Web of Science, Embase, Cochrane Library, and China National Knowledge Infrastructure databases were thoroughly searched. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to evaluate the prognostic value of the SII for survival outcomes. The combined odds ratios (ORs) and 95% CIs were used to evaluate the correlation between SII and clinicopathological features. Results Eight studies comprising 2,267 patients were included in the meta-analysis. Pooled analyses indicated that a high SII was significantly associated with worse overall survival (OS) (HR=1.52, 95% CI=1.15–2.00, p=0.003) but not progression-free survival (HR=1.38, 95% CI=0.81–2.35, p=0.238) in patients with SCLC. Moreover, a high SII was associated with extensive-stage SCLC (OR=2.43, 95% CI=1.86–3.17, p<0.001). However, there was a non-significant correlation between SII and age, sex, smoking history, Karnofsky Performance Status score, or initial therapeutic response. Conclusion Our meta-analysis demonstrated that a high SII could be an efficient prognostic indicator of OS in SCLC. We recommend adopting SII to predict OS in patients with SCLC, and SII in combination with other parameters or biomarkers may aid in addressing the clinical strategy and choosing the best treatment for an individual patient.
EPOS trial: the effect of air filtration through a plasma chamber on the incidence of surgical site infection in orthopaedic surgery: a study protocol of a randomised, double-blind, placebo-controlled trial

Introduction There is controversy regarding the importance of air-transmitted infections for surgical site infections (SSIs) after orthopaedic surgery. Research has been hindered by both the inability in blinding the exposure, and by the need for recruiting large enough cohorts. The aim of this study is to investigate whether using a new form of air purifier using plasma air purification (PAP) in operating rooms (ORs) lowers the SSI rate or not. Methods and analysis Multicentre, double-blind, cluster-randomised, placebo-controlled trial conducted at seven hospitals in 2017–2022. All patients that undergo orthopaedic surgery for minimum 30 min are included. Intervention group: patients operated in OR with PAP devices turned on. Control group: patients operated in OR with PAP devices turned off. Randomisation: each OR will be randomised in periods of 4 weeks, 6 weeks or 8 weeks to either have the devices on or off. Primary outcome: any SSI postoperatively defined as a composite endpoint of any of the following: use of isoxazolylpenicillin, clindamycin or rifampicin for 2 days or more, International Classification of Diseases codes or Nordic Medico-Statistical Committee codes indicating postoperative infection. In a second step, we will perform a chart review on those patients with positive indicators of SSI to further validate the outcome. Secondary outcomes are described in the Methods section. Power: we assume an SSI rate of 2%, an SSI reduction rate of 25% and we need approximately 45 000 patients to attain a power of 80% at a significance level of 0.05. Ethics and dissemination The study is approved by the Swedish Ethical Review Authority. The interim analysis results from the study will be presented only to the researchers involved unless the study thereafter is interrupted for whatever reason. Publication in a medical journal will be presented after inclusion of the last patient. Trial registration number NCT02695368.
Video Denoising Method Research on Industrial X-Ray Imaging

This article introduced the structure of an X-ray image intensifier video frequency imaging system and its performance,analyzed the influence factors on imaging quality.The non-uniformity of transformation screen and the CCD imaging system response was the primary factor to affect the examination sensitivity;The quantum fluctuation and the scattering-created stochastic noise also seriously influenced imaging quality.This article first used carries model of non-uniformity correction to the system,then applied the recursive filter noise reduction for the stochastic noise,resulting in an effective improvement on system's imaging quality as compared withe the sole denoising method.
Strategies for Improving Participation in Human Papillomavirus Vaccination Among Young Adults in the Capital of Iran: A Qualitative–Exploratory Study

Background: Different strategies can promote healthy behaviors. Although the human papillomavirus (HPV) vaccine is very important due to its effect in reducing cervical cancer, the behavior of HPV vaccination is low among young adults in Iran. Therefore, this study aimed to determine strategies for improving HPV vaccination among young adults. Methods: The present study was conducted with a qualitative content analysis method. The participants were 30 health professionals and young adults in Tehran city who were selected using purposive and snowball sampling. The data were collected through semistructured interviews and analyzed by Graneheim and Lundman's approach. Results: In total, two categories were identified: (1) access to services: access to the vaccine, vaccine insurance coverage; (2) educational coverage: subgroup training, educational content, time for training, educational channels, education strategies, and educational conditions. Conclusions: This is the first study conducted to determine strategies for improving HPV vaccination in Iran. The policymakers and planners, schools, and health centers are recommended to use the strategies obtained from this study to increase HPV vaccine imports, as well as increase the community members' knowledge and acceptance of the HPV vaccine.
Heat Treatment Promotes Ubiquitin-Mediated Proteolysis of SARS-CoV-2 RNA Polymerase and Decreases Viral Load

Despite extensive efforts, COVID-19 pandemic caused by the SARS-CoV-2 virus is still at large. Vaccination is an effective approach to curb virus spread, but several variants (e.g., delta, delta plus, omicron, and IHU) appear to weaken or possibly escape immune protection. Thus, novel and quickly scalable approaches to restrain SARS-CoV-2 are urgently needed. Multiple evidences showed thermal sensitivity of SARS-CoV-2 and negative correlation between environmental temperature and COVID-19 transmission with unknown mechanism. Here, we reveal a potential mechanism by which mild heat treatment destabilizes the wild-type RNA-dependent RNA polymerase (also known as nonstructural protein 12 (NSP12)) of SARS-CoV-2 as well as the P323L mutant commonly found in SARS-CoV-2 variants, including omicron and IHU. Mechanistically, heat treatment promotes E3 ubiquitin ligase ZNF598-dependent NSP12 ubiquitination leading to proteasomal degradation and significantly decreases SARS-CoV-2 RNA copy number and viral titer. A mild daily heat treatment maintains low levels of both wild-type and P323L mutant of NSP12, suggesting clinical potential. Collectively, this novel mechanism, heat-induced NSP12 degradation, suggests a prospective heat-based intervention against SARS-CoV-2.
Initial Study of a Wire Mesh Tomography Sensor for Liquid/Gas Component Investigation

Experimental studies have been carried out to study the principle operation of the conductive type wire-mesh tomography sensor and analyse the wire-mesh tomography sensor for the liquid/gas two-phase flow interface and void fraction distribution in a process column. The measurement of the two-phase flows in the process column is based on the cross-sectional local instantaneous conductivity. The sensor consists of two planes of parallel electrode wires with 16 electrodes each and was placed orthogonally with each plane. The sensor electrode wires were made of tinned copper wire with an outer diameter of 0.91 mm which stretched over the sensor fixture. Therefore, this result in the mesh grid size with 5.53×5.53mm². The wire-mesh sensor was tested in a horizontal liquid/gas two-phase flows process column with nominal diameter of 95.6 mm and the sampling frequency of 5882.3529 Hz. The tomogram results show that the wire-mesh tomography provides significant results to represent the void fraction distribution in the process column and estimation error was found in the liquid/gas interface level.
Time Metaphorization: Duality of Time as a Pursuer vis-à-vis Object of Pursuit

This paper discusses the duality of metaphorical conceptualizations of time focusing in particular on time as a pursuerand time as an object of pursuit metaphors, which are based the Figure–Ground reversal of each other. Using examples taken from the British National Corpus, it argues that these metaphorical conceptualizations of time are inconsistent with each other. This inconsistency resembles the discrepancy between the moving time and moving observer metaphors, which are, in strict terms, also inconsistent with each other. Looking at such contrasts between metaphorical representations of time from a broader perspective suggests that the concept of time arises from different, both physical and socio-cultural, dimensions of human experience.
ASTROVIRUS INFECTION IN CHILDREN IN LAGOS, NIGERIA Ayolabi,

A preliminary investigation was conducted to screen for astrovirus in Lagos. Two hundred and fifteen (215) faecal samples collected from children under 5 years old with diarrhoea (161) and without diarrhoea (54) admitted at paediatric clinics in Lagos State were studied. The stool specimens were examined for the presence of human astrovirus antigen using a monoclonal antibody-based ELISA (Astrovirus RIDASCREEN r-Biopharm, Germany) technique. Astrovirus was detected in 40.4 percent (65/161) of the diarrhoeal stools compared to 11.1 percent (6/54) of the control specimens. Astrovirus was found to infect younger children and about three quarter of the children infected was under 12 months of age. The prevalence of infection decreases with age group and was statistically significant (P = 0.0470). Although, prevalence of infection is more in males than females but this is not significant. This study shows that astrovirus is an important agent of acute gastroenteritis among children in Lagos state.
Factors Affecting the Application of Managerial Accounting in Small and Medium-Sized Enterprises in Vietnam*

The article analyzes the impact of factors affecting the use of management accounting in small and medium-sized firms in Vietnam, which adds to the empirical evidence on these factorsThe survey results collected 328 questionnaires using a questionnaire survey of managers at all levels, chief accountants, and accountants of 89 small and medium firms in Vietnam. Some questionnaires were invalid due to many blank cells, hence the author chose to use 315 questionnaires. Quantitative research was carried out with SPSS 25 software. Research results show that five factors have a positive influence on the application of management accounting including Competitive pressure, Decentralization of responsibility, Application of information technology, the level of interest of managers, and the quality of human resources, in which the application of information technology and competitive pressure are the factors that have the strongest influence on the application of management accounting in small and medium enterprises in Vietnam. Based on the findings of the study, the author has proposed recommendations to help small and medium-sized businesses improve their ability to successfully apply management accounting techniques, thereby improving their competitiveness and efficiency performance and contributing to the long-term sustainability of their businesses.
Warming Responses of Leaf Morphology Are Highly Variable among Tropical Tree Species

Leaf morphological traits vary along climate gradients, but it is currently unclear to what extent this results from acclimation rather than adaptation. Knowing so is important for predicting the functioning of long-lived organisms, such as trees, in a rapidly changing climate. We investigated the leaf morphological warming responses of 18 tropical tree species with early (ES) abd late (LS) successional strategies, planted at three sites along an elevation gradient from 2400 m a.s. l. (15.2 °C mean temperature) to 1300 m a.s. l. (20.6 °C mean temperature) in Rwanda. Leaf size expressed as leaf area (LA) and leaf mass per area (LMA) decreased, while leaf width-to-length ratio (W/L) increased with warming, but only for one third to half of the species. While LA decreased in ES species, but mostly not in LS species, changes in LMA and leaf W/L were common in both successional groups. ES species had lower LMA and higher LA and leaf W/L compared to LS species. Values of LMA and LA of juvenile trees in this study were mostly similar to corresponding data on four mature tree species in another elevation-gradient study in Rwanda, indicating that our results are applicable also to mature forest trees. We conclude that leaf morphological responses to warming differ greatly between both successional groups and individual species, with potential consequences for species competitiveness and community composition in a warmer climate.
Research on public health crisis early warning system based on context awareness

BACKGROUND: With the continuous expansion of urban scale and the increasing concentration of population, public health crisis has become an important part of urban residents’ health management. The outbreak of the COVID-19 pandemic in Wuhan in 2020 has sounded the alarm. OBJECTIVE: With the government at all levels to carry out the construction of urban Internet of things and information internet, the Internet backbone network has been built, deployed a large number of sensors, and collected a large number of urban situation data. METHODS: In this paper, situational awareness technology is introduced into public health emergency services. RESULTS: By constructing ontology, situational data and residents’ health data are integrated. Through key technologies such as situational data collection, data fusion and data mining, real-time perception of environmental conditions of public health emergency scene is realized, and situational data fusion and situational information reasoning model are constructed. CONCLUSIONS: The model is applied to the public health crisis emergency simulation system to verify the effectiveness of the model.
Nonlinear Relationship Between Chinese Visceral Adiposity Index and New-Onset Myocardial Infarction in Patients with Hypertension and Obstructive Sleep Apnoea: Insights from a Cohort Study

Purpose We aimed to investigate the relationship between the Chinese visceral adiposity index (CVAI) and the risk of new-onset myocardial infarction (MI) in patients with hypertension and obstructive sleep apnoea (OSA) and to inspect possible modifiers of the effect. Methods The Cox regression model was used to evaluate the relationship between baseline CVAI and risk of new-onset MI. A generalized additive model was used to identify the nonlinear relationship. Besides, we conducted subgroup analyses and interaction tests. Results A total of 2177 patients with hypertension and OSA undergoing polysomnography were enrolled in this study. During a median follow-up period of 87 months, 82 participants developed new-onset MI. Overall, CVAI was positively related to the risk of new-onset MI (per 1 SD increase; HR = 1.54, 95% CI: 1.28–1.85). In multivariable-adjusted models, the risk of new-onset MI increased with quartiles of CVAI, with an HR of 3.64 (95% CI: 1.94–6.83) for quartile 4 compared with quartile 1. The generalized additive model and smoothed curve fit revealed a nonlinear relationship between CVAI and risk of new-onset MI with an inflection point of approximately 112. None of the stratification variables had a significant effect on the relationship between CVAI and new-onset MI. Similar outcomes were observed in the sensitivity analysis. The addition of CVAI significantly improved reclassification and discrimination over the conventional model, with a category-free NRI of 0.132 (95% CI 0.021 to 0.236, P = 0.021) and an IDI of 0.012 (95% CI 0.005 to 0.023, P < 0.001). Conclusion This study demonstrated a nonlinear relationship between CVAI and the risk of new-onset MI in patients with hypertension and OSA. Higher CVAI was significantly associated with the risk of new-onset MI when CVAI was ≥112.
Imidazole derivative improves antioxidant status and causes differential alteration of redox-status in Drosophila melanogaster

This study investigated the toxicity of a new imidazole compound, 1-(1,4,5-triphenyl-1H-imidazol-2-yl)naphthalen-2-ol, through the evaluation of selected oxidative stress markers and antioxidants. Both male and female D. melanogaster (3–5 days old) were fed a diet containing the imidazole derivative (20, 50, and 100 mg IMZ/kg diet) for five days. After cessation of imidazole treatment, half the population of the imidazole-exposed flies was homogenized for biochemical assays, while the other half of the flies was allowed to have a normal diet for an additional five days to see if any induced effect would be resolved. Imidazole derivatives did not significantly affect the survival rate of flies. Furthermore, there was a significant increase in reduced glutathione level (GSH) (p < 0.05) when compared to the control group. Also, the activity of catalase was significantly increased in flies fed with the 50 mg IMZ/kg diet. An increase was observed in the levels of glutathione peroxidase, glutathione transferase, total protein level, nitric oxide, and lipid peroxidation, but this elevation was not statistically significant compared to the control group. Flies fed the 100 mg IMZ/kg diet showed a significant increase in protein carbonyl level and DNA fragmentation, implying that the imidazole derivative is toxic to the flies at higher concentrations. However, this toxic effect was resolved within five days after treatment cessation. The results support the safety prospects of 1-(1,4,5-triphenyl-1H-imidazol-2-yl)-naphthalen-2-ol as an alternative anti-parasite therapy. The present findings represent a portion of the critical pre-clinical data needed to warrant further experiments and development of the imidazole-based compound as a prospective anti-parasite therapy.
Development of a Low-Cost 6 DOF Brick Tracking System for Use in Advanced Gas-Cooled Reactor Model Tests

This paper presents the design of a low-cost, compact instrumentation system to enable six degree of freedom motion tracking of acetal bricks within an experimental model of a cracked Advanced Gas-Cooled Reactor (AGR) core. The system comprises optical and inertial sensors and capitalises on the advantages offered by data fusion techniques. The optical system tracks LED indicators, allowing a brick to be accurately located even in cluttered images. The LED positions are identified using a geometrical correspondence algorithm, which was optimised to be computationally efficient for shallow movements, and complex camera distortions are corrected using a versatile Incident Ray-Tracking calibration. Then, a Perspective-Ray-based Scaled Orthographic projection with Iteration (PRSOI) algorithm is applied to each LED position to determine the six degree of freedom pose. Results from experiments show that the system achieves a low Root Mean Squared (RMS) error of 0.2296 mm in x, 0.3943 mm in y, and 0.0703 mm in z. Although providing an accurate measurement solution, the optical tracking system has a low sample rate and requires the line of sight to be maintained throughout each test. To increase the robustness, accuracy, and sampling frequency of the system, the optical system can be augmented with an Inertial Measurement Unit (IMU). This paper presents a method to integrate the optical system and IMU data by accurately timestamping data from each set of sensors and aligning the two coordinate axes. Once miniaturised, the developed system will be used to track smaller components within the AGR models that cannot be tracked with current instrumentation, expanding reactor core modelling capabilities.
Adaptive Model Predictive Control Including Battery Thermal Limitations for Fuel Consumption Reduction in P2 Hybrid Electric Vehicles

The primary objective of a hybrid electric vehicle (HEV) is to optimize the energy consumption of the automotive powertrain. This optimization has to be applied while respecting the operating conditions of the battery. Otherwise, there is a risk of compromising the battery life and thermal runaway that may result from excessive power transfer across the battery. Such considerations are critical if factoring in the low battery capacity and the passive battery cooling technology that is commonly associated with HEVs. The literature has proposed many solutions to HEV energy optimization. However, only a few of the solutions have addressed this optimization in the presence of thermal constraints. In this paper, a strategy for energy optimization in the presence of thermal constraints is developed for P2 HEVs based on battery sizing and the application of model predictive control (MPC) strategy. To analyse this approach, an electro-thermal battery pack model is integrated with an off-axis P2 HEV powertrain. The battery pack is properly sized to prevent thermal runaway while improving the energy consumption. The power splitting, thermal enhancement and energy optimization of the complex and nonlinear system are handled in this work with an adaptive MPC operated within a moving finite prediction horizon. The simulation results of the HEV SUV demonstrate that, by applying thermal constraints, energy consumption for a 0.9 kWh battery capacity can be reduced by 11.3% relative to the conventional vehicle. This corresponds to about a 1.5% energy increase when there is no thermal constraint. However, by increasing the battery capacity to 1.5 kWh (14s10p), it is possible to reduce the energy consumption by 15.7%. Additional benefits associated with the predictive capability of MPC are reported in terms of energy minimization and thermal improvement.
Spatial Distribution of Eco-Friendly Coffee Shops in Malang City

Along with the increasing population and lifestyle of people drinking coffee, coffee shops increased significantly. This not only impacts socially and economically but also impacts the environment. Sustainability demands coffee shops to manage environmental problems that arise from business activities. This article aims to examine the environmental aspects (energy, water, waste) and spatial aspects of coffee shops in Malang city. The methodology of this research was focused on data acquisition related to tabular and geospatial information provided online through social media, news websites, and online food order applications. Descriptive quantitative and spatial approaches were made in this research. The results showed that most coffee shops in Malang city-operated daily for 7-12 hours, provided food and beverages, and used a combination of glass/porcelain and disposable materials as the packaging. These could trigger problems related to high energy and water consumption and waste generalization. Meanwhile, several coffee shops began to initiate the green action by using steel straw, reusing cups, and reducing plastic. As located mainly in the city center and densely populated area, the local government should pay more attention to this area regarding environmental management and urban planning. Hopefully, the emergence of coffee shops can contribute positively socially and economically without exacerbating the urban environmental problems.