Miracle-dz/UniFAR-FTUs huggingface dataset:
PIKfyve inhibition reveals a novel role for Inpp4b in the regulation of PtdIns(3)P and lysosome dynamics

Lysosome membranes contain diverse phosphoinositide (PtdIns) lipids that co-ordinate lysosome function and dynamics. The PtdIns repertoire on lysosomes is tightly regulated by the action of diverse PtdIns kinases and phosphatases. Specific roles for PtdIns in lysosomal function and dynamics are currently unclear and require further investigation. PIKfyve, a lipid kinase which synthesizes PtdIns(3,5)P2 from PtdIns(3)P, controls lysosome “fusion-fission” cycles dynamics, autophagosome turnover and endocytic cargo delivery. We have recently characterized a role for INPP4B, a PtdIns phosphatase which hydrolyses PtdIns(3,4)P2 to form PtdIns(3)P, in the regulation of lysosomal biogenesis and function. To gain a better understanding of PtdIns homeostasis on lysosomes, we investigated the consequence of disrupting PIKfyve in Inpp4b-deficient mouse embryonic fibroblasts. Surprisingly, simultaneous inhibition of Inpp4b and PIKfyve functions impair lysosome “fission” dynamics and thereby exacerbate lysosome enlargement, inhibit autophagic flux. Further examination into the underlying processes that may explain exaggerated lysosome enlargement revealed elevated levels of lysosome associated PtdIns(3)P as contributing factors that control lysosome morphology in cells where Inpp4b and PIKfyve are disrupted. Overall, our study suggests that lysosomal functions are regulated by Inpp4b, through a paradoxical role in suppressing the induction of PtdIns(3)P production. SUMMARY STATEMENT In this study we identify a novel crosstalk between Inpp4b and PIKfyve. This crosstalk regulates lysosome membrane phosphoinositide composition and lysosomal homeostasis. Our data demonstrate that Inpp4b restricts VPS34-dependent induction of PtdIns(3)P levels, which is activated upon apilimod-mediated PIKfyve inhibition. Through this mechanism, Inpp4b contributes to the regulation of lysosomal membrane dynamics and homeostasis.
Implications of the different classes of exceptions experienced during the cots processor test flight on the argos satellite

The Advanced Space Computing and Autonomy Testbed on the ARGOS Satellite provided the first direct, on orbit comparison of a modern radiation hardened 32 bit processor with a similar COTS processor. This paper describes the experiments in radiation effects testing and fault tolerant software that were performed on ARGOS, correlates the result with ground testing and similar programs, and provides the authors’ best estimates of the causes of error and advice on how to design processors for future systems that provide maximum leverage of state-ofthe-art COTS components with acceptable operation in a radiation environment. Interesting observations include a higher then expected error rate from the RAD-hard processor system, and acceptable error rates from the COTS system.
Mapping policies and programmes: the use of GIS to communicate spatial relationships in England

It has long been acknowledged that there is a gap between the advancement of GIS in the research field and its application in planning practice. This paper demonstrates the potential for employing simple GIS mapping overlays as a way of communicating complex planning issues in a ‘language’ that is easily understandable and effective at stimulating policy debate, critical thinking, and learning. The analysis focuses on capturing the synergies and conflicts in two key planning challenges in England, progrowth and housing delivery agendas. In a political context where spatial evidence-based policy making has been eroded in recent years, the analysis demonstrates the need for policy makers to ‘think spatially, act spatially’ when developing different policies and programmes. The paper concludes that only by making spatial relationships of policies and programmes explicit in a manner that is easily understood by a range of actors, can different spatial scenarios and metaphors of future opportunities and challenges be developed to inform long-range development and planning.
Study o f E scherichia C oli Verotoxigenic Preva lence i n F eces o f S laughtered Cows in Tabriz Abattoir by PCR

E.coli is natural flora i n l arge i ntestine a nd m ain c ommon pat hogen between human a nd ani mal and transmitted by food that i s im portant ca use of d iarrhea infections in cows. T he aim of th is s tudy was to identification and separation of E.coli from feces of cows. In t his study by r eferring t o Tabr iz a battoir about 151 fecal samples were obt ained by chance and s amples were i mmediately t ransferred t o m icrobiology laboratory. After enrichment and culturing of samples in pl ates revealed t hat of 151 fecal samples, 17 samples (11.25%) w ere E.coli verotoxigenic. T he achieved results showed that t he prevalence rate of E . coli in Tabriz is v ery high and must ta ke measures in this fie ld. Key w ords: verotoxigenic E . coli, PCR, cow, Tabriz a battoir.
Controlling production dynamics - managing uncertainties with automatic production control

A new dynamic and continuous production model for the planning level, based on methods of control theory, will be presented in this paper. For the control task, a decentral backlog controller has been developed. The controller adjusts the capacity of the individual work system in order to eliminate the backlog as soon as possible. A central WIP-controller secures that only the amount of work that can be handled by means of flexible capacities will be released to the job-shop. The objective is to develop a feedback control for production planning and control with defined control and reference variables based on the logistical objectives.
An interactive fly-path planning using potential fields and cell decomposition for virtual endoscopy

Virtual colonoscopy has been developed as a noninvasive computerized medical procedure for examining the entire colon to detect polyps. Our group has successfully implemented an interactive navigation using a physically based camera control model and a hardware-assisted visibility algorithm. Unfortunately, the pre-processing (skeleton and potential field generations) consumes too much computing time to be acceptable in an interactive clinical environment. In this work, we focus on skeleton simplification by eliminating excessive inconsistent branches. The simplification is performed before skeleton generation. The idea is to utilize a hierarchical analysis to determine principal points for the skeleton. We also propose dynamic target navigation for virtual endoscopy. We combine potentials derived from the distance between source and target positions and from the distance between source and colon surface to guide path search processes. These potentials are utilized to assign priority in choosing the paths far away from colon wall and in the direction of target positions.
Traffic Safety for Electric Bike Riders in China

The use of electric bikes (e-bikes) in China has grown tremendously in the past decade. Traffic safety for e-bike riders is an issue of growing public concern because the number of fatalities and injuries is increasing. A study was conducted to identify risk factors affecting involvement of e-bike riders in accidents and to establish the relationships between safety attitudes, risk perception, and aberrant riding behaviors. The data used for analysis were obtained from a self-reported questionnaire survey of a sample of 603 e-bike riders in two large cities in China. The results showed that both gender and automobile driving experience were significantly associated with at-fault accident involvement. Males were more likely to have at-fault accidents than were females, and riders with an automobile driver's license were less likely to have accidents than were those without a driver's license. Two types of aberrant riding behaviors, errors and aggressive behaviors, were found to be significant factors for predicting at-fault accident involvement. Analysis with a structural equation model indicated that safety attitudes and risk perception both significantly affected aberrant riding behaviors. E-bike riders with stronger positive attitudes toward safety and more worry and concern about their traffic risk tended to be less likely to have aberrant riding behaviors. Practical implications for improving road safety of e-bike riders are discussed.
Florida Blueberry Integrated Pest Management Guide

HS-1156 is a 35-page illustrated guide adapted for Florida from the Southeast Regional Blueberry Integrated Management Guide by Jeffrey G. Williamson, Philip F. Harmon, and Oscar E. Liburd. Primarily tabular in format, it also includes links to additional resources, text descriptions of key pests by stages of flower bud development, and an illustrated guide to recognized stages. Published by the UF Department of Horticultural Science, March 2008. HS1156/HS380: 2022 Florida Blueberry Integrated Pest Management Guide (ufl.edu)
Study on Linear Active Disturbance Rejection Control Technique and its Application in Ship-Borne Servo Control System

In order to improve the rejection ability of the boat rocking disturbance and wind load disturbance on Ship-borne Servo Control System, the position linear ADRC (LADRC) is designed. First, mathematical model of Ship-borne Servo Control System is established, and PID control method is used for simulation. Methods used LADRC, estimated and compensated the wind disturbances and boats rocking disturbances, greatly. The simulation results show that ADRC method for active immunity, which greatly improves the immunity system and tracking accuracy, and the parameter adjustment is simple, just adjust a parameter can get good control performance.
Chemical Coagulation: An Effective Treatment Technique for Industrial Wastewater

Industrial sector is a backbone of the economy throughout the world. Despite that there are a lot of benefits; such as development of urbanization, major contributor in economy’s growth is sign of industrial development. There are a lot of adverse effects on environment including depletion and damage of our natural and precious resources. Textile, cement, paper and pulp, sugarcane, food, pharmaceuticals, chemical, paint and other industries are largest consumers of the freshwater; for meeting the requirements of industrial production requirement for the industrial sector for their production. As a result the discharged huge amount of water in form of highly polluted water, this is a great threat to our ecosystem. The unplanned industrialization is a prime responsible for degradation of environment. If industrial wastewater is not properly treated instantly, it may create foulest and septic conditions in adjacent parts of the industrial areas. The discharges acute poisonous wastewater by different industries is responsible for reduction of penetration in crops, and severely affects aquatic life. There are many treatment techniques such as coagulation, adsorption, membrane, biological etc. by different research studies disclosed that coagulation with different chemicals alum, ferric chloride, lime, PACl, PVA and ferrous sulphate are very effective for remove of pollution. The industrial wastewater creates several problems such as health problems, aquatic life including water pollution. In this paper reviews the chemical coagulation treatment technologies for industrial wastewater.
Emotional intelligence: A catalyst for inspirational leadership and management excellence

Although a centuries-old phenomenon, emotional intelligence has received an enormous amount of attention and popularity in various academic and non-academic circles during the last two decades. Emotionally intelligent abilities, capacities and skills are increasingly becoming significant and inevitable almost in all works of life ranging from effective leadership, building teams, to the globe-spanning network of communication, development of human potential and performance, social skills and economic and political life. In this dynamic and complexly integrated international economic system, tomorrow's leaders will have to facilitate others to develop their own leadership, skills and potential with the help of emotional intelligence. Be that as it may, there still exists continuing debate among researchers pertaining to the best method for measuring this construct of emotional intelligence. Keeping this in view, the present paper aims to introduce a new measure, based on a holistic and system modelling approach, to conceptualise and measure the phenomenon of emotional intelligence. It develops, constructs and validates a model that conceptualises and measures the phenomenon of emotional intelligence by constructing and using a latent variable structural equation model within the certain boundaries of the psychosocial system. It will provide us with a measurement or index of emotional intelligence at individual level. An emotional intelligence index will indicate the extent to which a particular individual or a group of people is emotionally intelligent and which areas lack this intelligence, if any. Strengths and weaknesses of various components of the model will also indicate characteristics at a certain level in order to pinpoint what exactly an individual or group of individuals requires to improve its emotionally intelligent capabilities.
Simultaneous configuration of platform products and manufacturing supply chains: comparative investigation into impacts of different supply chain coordination schemes

It is widely acknowledged that effective supply chain management calls for coordination among the various chain members. This article studies the impacts of different supply chain coordination schemes on the optimal decisions of simultaneous configuration of platform products and their supply chain, as well as the supply chain performance. Three possible coordination scenarios of a supply chain consisting of one manufacturer and multiple suppliers are examined. In scenario non-interactive supplier, the manufacturer optimises its own costs and imposes the resulting policy to the suppliers without any question. In scenario non-cooperative supplier, each level of the chain is optimising a local pay-off function in a decentralised way. In the third scenario cooperative supplier, both levels of the chain are assumed to cooperate in the sense that their common objective is to minimise the overall operational cost. This article addresses the above scenarios through a comprehensive industrial case. Experimental results show that the manufacturer would prefer a cooperative relationship with its suppliers. With a higher level of supply chain integration, the manufacturer could serve the market with higher product variety. Suppliers with higher flexibility would prefer to establish a more cooperative relationship with the manufacturer. The supply chain system becomes more effective under a higher level of supply chain integration.
Online Control of Service Function Chainings Across Geo-Distributed Datacenters

Network Function Virtualization (NFV) provides the possibility to implement complex network functions from dedicated hardware to software instances called Virtual Network Functions (VNF) by leveraging the virtualization technology. Service Function Chaining (SFC) is therefore defined as a chain-ordered set of placed VNFs that handles the traffic of the delivery and control of a specific application. Due to the advantages of flexibility, efficiency, scalability, and short deployment cycles, NFV has been widely recognized as the next-generation network service provisioning paradigm. In this paper, we study the problem of online SFC control across geo-distributed datacenters, which is to dynamically place required VNFs on datacenter nodes and find routing paths between each adjacent VNF pair for each NFV service flow that varies over time. To that end, we first formulate this problem as an offline optimization problem whose goal is to minimize the average delay such that each datacenter's average cost does not exceed a given expense value. Considering that the offline optimization requires complete offline network information which is difficult to obtain or predict in practice, we present an online SFC control framework without requiring any future information about the traffic demands. More specifically, we leverage the Lyapunov optimization technique to formulate the problem as a series of one-time slot offline optimization problems and then apply a primal-decomposition method to solve each one-time slot problem. Simulation results reveal that our proposed online SFC control framework can efficiently reduce long-term average delay while keeping datacenter's long-term average cost consumption low.
Electromigration: the time bomb in deep-submicron ICs

Electromigration results from the movement of metal ions as current flows through power wires in integrated circuits, causing voids and hillocks in the wires. The voids increase resistance or even cause opens in the wires, while hillocks can cause shorts to adjacent wires. This paper describes how electromigration is a ticking time bomb in IC designs, which can trigger a system failure at some undefined future time. The phenomenon is particularly likely to afflict the thin, tightly spaced power-distribution lines of deep-submicron designs.
Understanding Service Experience: A Critical Incident Technique Approach

Service experience encompass positive or negatives experiences, whilst also differs between individuals while quality begins with the design of the service delivery system and thus being assessed by the customers during the service delivery process. Limited empirical study had been done in the identification of hotel failures while there is also less understanding on the attribution of these failures. Current information and data available are not sufficient and very minimal in the identification of the current and potential hotel failures. As service experience is a subjective matter and differs between individuals, a qualitative stance is deemed appropriate to be applied. In order to obtain this, a technique known as the Critical Incident Technique (CIT) was utilized to investigate the perception of Langkawi resort hotel guests towards their service experiences during their stay in Langkawi, giving particular attention on negative experiences encountered. CIT was deemed suitable to be employed by having customers convey their personal experiences in their own words regarding their recent hotel stay, which are memorable to them either positively or negatively. CIT consists of a specifically defined procedure for collecting important observations of past events, which will then be classified into natural groupings between the events. This paper will highlight an analytical framework of CIT as forwarded by Gilbert and Lockwood (1999) which proposes three major stages of CIT application. These three stages are then broken down into six steps in constructing an explanatory framework of the data collected. By applying CIT, this paper aims to identify the negative experiences that guests generally encounter during their stay in Langkawi resort hotels. The application of CIT has led to the classification of negative incidents into categories and subcategories. It also aims to explore who is attributable in influencing the negative incidents encountered. This study is considered significant to provide findings which can assist in the identification of common failures that guests generally encounter while staying in hotels in Langkawi whilst also identifying what attributes to these failures. Hence corrective efforts can be adjusted to improve resort hotel’s service experience.
Predicting Impacts of Climate Change on Chinese Hybrid Poplar Using Maxent Modeling

Maximum entropy (Maxent) modeling was used to predict the potential climate habitat distribution of Chinese hybrid poplar (clone I-63, I-69 and I-72). Occurrence data were collected from literatures. The Maxent model performed better than random with an average cross-validated AUC value of 0.96. Under the three future climate scenarios (emission scenarios A1B, A2 and B1), the geographic distribution of suitable habitat would shift from southwest to northeast, the suitable habitat area of scenario A1B increased most compared to other two, the ranking of the loss habitat area was scenario B1 > scenario A2 > scenario A1B, and the gain habitat area was scenario A1B > scenario A2 > scenario B1. The results of this work could be used as scientific basis for adapting and mitigating Chinese hybrid poplar planting to a climate change.
The Nevada Initiative: A Risk Communication Fiasco

The U.S. Congress has designated Yucca Mountain, Nevada as the only potential site to be studied for the nation`s first high-level nuclear waste repository. People in Nevada strongly oppose the program, managed by the U.S. Department of Energy. Survey research shows that the public believes there are great risks from a repository program, in contrast to a majority of scientists who feel the risks are acceptably small. Delays in the repository program resulting in part from public opposition in Nevada have concerned the nuclear power industry, which collects the fees for the federal repository program and believes it needs the repository as a final disposal facility for its high-level nuclear wastes. To assist the repository program, the American Nuclear Energy Council (ANEC), an industry group, sponsored a massive advertising campaign in Nevada. The campaign attempted to assure people that the risks of a repository were small and that the repository studies should proceed. The campaign failed because its managers misunderstood the issues underlying the controversy, attempted a covert manipulation of public opinion that was revealed, and most importantly, lacked the public trust that was necessary to communicate credibly about the risks of a nuclear waste facility. This article describes themore » advertising campaign and its effects. The manner in which the ANEC campaign itself became a controversial public issue is reviewed. The advertising campaign is discussed as it relates to risk assessment and communication. 29 refs., 2 tabs. « less
Trust establishment in sensor networks: behaviour-based, certificate-based and a combinational approach

Sensor networks highly depend on the distributed cooperation among network nodes. Trust establishment frameworks provide the means for representing, evaluating, maintaining and distributing trust within the network, and serve as the basis for higher level security services. This paper provides a state-of-the art review of trust establishment frameworks for ad hoc and sensor networks. Certain types of frameworks are identified, such as behaviour-based and certificate-based, according to their scope, purpose and admissible types of evidence. The review is complemented by a comparative study built both on criteria specific to each category and on common criteria, grouped into three distinct classes: supported trust characteristics, complexity and requirements and deployment complexity and flexibility. We then present a trust establishment framework targeted for sensor networks that combines aspects from the two alternative approaches on trust establishment on common evaluation metrics, so that it can uniformly support the needs of nodes with highly diverse network roles and capabilities.