Miracle-dz/UniFAR-FTUs huggingface dataset:
Arqueo 2.0. Renovación metodológica de la prospección arqueológica de zonas de montaña

Hicieron falta varias décadas de interacción y diálogo entre las ciencias humanas y las ciencias medioambientales, además de una serie de avances metodológicos, para que los espacios de altura fueran considerados algo más que inmutables y átonos. Sometidos a un cuestionamiento interdisciplinario integrado, revelan no una, sino muchas historias y dinámicas complejas. Historizar las zonas de montaña permite invertir el punto de vista global sobre las sociedades pirenaicas y reconsiderar los sistemas de valles. Es evidente que los equipos que participan en esta línea de investigación se enfrentan al problema de adquirir información primaria. Siendo requisito indispensable de toda investigación arqueológica, la prospección en alta montaña presenta especificidades propias y desafíos metodológicos particulares. Ahora es posible pensar en nuevos procedimientos de adquisición de información arqueológica basados en cinco grandes avances: la diversificación y miniaturización de los sensores, que permiten transportarlos en drones; la reducción significativa de los costes de adquisición de los vehículos aéreos; un entorno de vuelo cada vez más seguro; las herramientas de tratamiento de datos y el trabajo sobre la ergonomía informática, y la apertura de posibilidades que ofrece la inteligencia artificial, que permite prever posibilidades futuras para optimizar la detección de restos arqueológicos en entornos de gran altitud.
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis

Background: A traumatic spinal cord injury (TSCI) can lead to severe nerve damage and disability. Cell transplantation therapy has shown great potential in the reconstruction of damaged spinal cords and promoting functional recovery. However, there is a lack of frontiers and futures analysis in the study of cell transplantation in TSCI. Methods: We used CiteSpace, VOSviewer and biblilometrix R package to perform bibliometric analysis on cell transplantation in TSCI from 2013 to 2023. Bibliometric records were extracted from English articles and reviews from the Web of Science core collection. Results: The bibliometric analysis included 284 papers published in 154 journals by 1,780 authors from 487 institutions in 41 countries and regions. The number of articles published in the past decade has fluctuated slightly, while the number of article citations has steadily increased. Mainland China and the United States are the leading countries and regions in this field, with the National Natural Science Foundation of China being the most funded foundation, and the United States being the country with the most funded articles. The University of Toronto in Canada is a prolific institution. Michael G. Fehlings has published the most articles, and D Michele Basso is the most cited author. Cell transplantation is the most published journal, and the Journal of Neurotrauma is the most cited journal. Cell and tissue engineering and clinical neurology are the basic disciplines in this field, and cutting-edge disciplines include developmental biology, biochemistry and molecular biology, and materials science and multidisciplinary. This study also helps scholars understand the current hotspots and future trends in this field. Marrow stromal cells, glial progenitor, and cell therapy are current research hotspots in this field, while nerve regeneration, cell therapy, and the safety of transplantation of transplantation may be potential research directions in the future. Conclusion: Cell transplantation after TSCI is receiving increasing attention. Cell therapy is both the frontier and a possible future trend in TSCI research. In addition, glial progenitor and marrow stromal cells are also current research hotspots. Meanwhile, nerve regeneration and safety of transplantation may be potential research directions. These findings will help further deepen research on cell transplantation for TSCI in scientific work.
Assessment of the Chemical and Microbiological Quality of Some Cheese Assortment in Egypt: Highlighting the incidence of multidrug-resistant Staphylococcus Species

Hard and semi-hard cheeses are popular dairy products in Egypt, but they may convey a health risk for consumers due to their poor hygienic quality and safety. One of the common problems that consumers face when buying these cheeses from the Egyptian market is the bad odour that shortly develops after purchase even though they are refrigerated. This problem may indicate a high bacterial count in the cheese or the presence of undesirable microorganisms. Therefore, the current study aimed to assess the hygienic quality and safety of some retailed cheese sold in Egyptian markets. One hundred hard and semi-hard cheese samples locally manufactured (including 34 Ras, 33 Cheddar, and 33 Gouda) were analyzed for their microbiological and chemical quality. The results indicated that the Ras cheese samples had the highest bacterial counts, salt, and fat content, while the Cheddar cheese samples had the highest acidity, moisture content and the lowest microbial load. The Gouda cheese samples had the lowest fat/total solids ratio and a variable bacterial count. Forty-five Staphylococcus aureus strains were isolated from the cheese samples; 25 of them were coagulase-positive. The antibiotic susceptibility of twenty isolates was phenotypically and genotypically evaluated. All isolates were resistant to Cefixime, Oxacillin, and Metronidazole, while sensitive to Amoxicillin/Clavulanic Acid and Linezolid. The resistance to other antibiotics varied among the isolates. The antibiotic resistance genes were detected by polymerase chain reaction (PCR). The obtained results indicate that the hard and semi-hard cheeses sold in many markets were poor in hygienic quality and safety and posed a health risk for consumers due to the presence of multidrug-resistant Staphylococcus species. Ras cheese was the worst cheese type in most quality and safety parameters. ـــــــــــــــــــــــــــــــــــــــــ
Seize the Last Day: Period-End-Point Sampling for Forecasts of Temporally Aggregated Data

Economists often need to forecast temporally aggregated data, such as monthly or quarterly averages. However, when the underlying data is persistent, constructing forecasts with aggregated data is inefficient. We propose a new forecasting method, Period-End-Point Sampling (PEPS), which uses end-of-period data to create point-in-time forecasts for aggregated data. We show that PEPS forecasts rival the accuracy of bottom-up forecasts and substantially outperform forecasts constructed with averaged data. Importantly, the PEPS method allows models to maintain the lower frequency of the forecast target. Real-time forecast applications to monthly nominal 10-year bond yields and the real prices of gasoline and copper find that disaggregated forecasts can outperform the end-of-month no-change forecasts
Rainbow link beamforming technology and relevant analysis

In the 5G era, millimeter wave has been mentioned as an important position. Millimeter wave has some problems that cannot be ignored: the free space path loss and atmospheric attenuation. To overcome these problems, millimeter wave systems rely on beamforming to overcome losses. Traditional techniques utilize phase antenna arrays for beamforming, which can cause delays in the time consumption and beam scheduling, and due to limited beams, this technology can only be connected to a limited number of devices, and each transmission occupies the entire bandwidth. This paper introduces a new technology called rainbow link, which is implemented by a new true time delay (TTD) array structure. This technology can achieve the allocation of different subcarriers to a large number of users in the corresponding beamforming direction. Users only need to select appropriate frequency resources. In this work, we calculate the performance of rainbow link with different parameters, and our results show that given 1 GHz bandwidth using 64 element antenna arrays, a rainbow-link cell achieves 1ms latency and 0.6M symbols per second with 0.03 active user rate.
Multi-objective Configuration Method for Mobile Energy Storage Aimed at Enhancing the Resilience of Regional Power Grid

Mobile energy storage has the advantages of high mobility, environmental friendliness, and wide application scenarios. It is widely used in important load protection, outdoor emergency power supply, and distribution network capacity expansion scenarios. This paper proposes a multi-objective configuration method for flexibly supporting the optimal operation of regional distribution networks. It aims to address the configuration problem of multi-mobile energy storage supporting regional power grid operation. A multi-objective optimization operation model for renewable energy distribution networks has been established. A multi-objective optimization method combining the normalized normal constraint method and improved composite method is proposed. It can achieve optimization decision-making of mobile energy storage positions, charging and discharging states, and power at different periods. Finally, simulation analysis is conducted on the IEEE 33 node distribution system to verify the effectiveness of the control method and algorithm.
HIPTox. Hazard Identification Platform to Assess the Health Impacts from Indoor and Outdoor Air Pollutant Exposures, through Mechanistic Toxicology: A single-centre double-blind human exposure trial protocol

Over the past decade, our understanding of the impact of air pollution on short- and long-term population health has advanced considerably, focusing on adverse effects on cardiovascular and respiratory systems. There is, however, increasing evidence that air pollution exposures affect cognitive function, particularly in susceptible groups. Our study seeks to assess and hazard rank the cognitive effects of prevalent indoor and outdoor pollutants through a single-center investigation on the cognitive functioning of healthy human volunteers aged 50 and above, with a familial predisposition to dementia. Participants will all undertake five sequential controlled exposures. The sources of the air pollution exposures are wood smoke, diesel exhaust, cleaning products, and cooking emissions, with clean air serving as the control. Pre- and post-exposure spirometry, nasal lavage, blood sampling, and cognitive assessments will be performed. Repeated testing pre- and post-exposure to controlled levels of pollutants will allow for the identification of acute changes in functioning as well as the detection of peripheral markers of neuroinflammation and neuronal toxicity. This comprehensive approach enables the identification of the most hazardous components in indoor and outdoor air pollutants and further understanding of the pathways contributing to neurodegenerative diseases. The results of this project have the potential to facilitate greater refinement in policy, emphasizing health-relevant pollutants and providing details to aid mitigation against pollutant-associated health risks.
Feasibility of adjuvant self-administered intravaginal 5-fluorouracil cream following primary treatment of cervical intraepithelial neoplasia grade 2 or 3 among women living with HIV in Kenya: study protocol for a pilot trial

Background: Women living with HIV (WLWH), the majority of whom live in low- and middle-income countries (LMICs), are at higher risk of cervical precancer, known as cervical intraepithelial neoplasia (CIN), and are up to six times more likely to get cervical cancer. Current CIN treatment methods, primarily ablation or excision, have high treatment failure rates among WLWH, up to 30% for CIN grade 2 or 3 (CIN2/3) at 24 months following ablation. Without strong follow-up many WLWH with treatment failure are at risk of developing invasive cervical cancer, highlighting the urgent need for improved CIN treatment methods. Prior studies in high-income countries (HICs) have demonstrated that 5-Fluorouracil (5-FU) cream, an antimetabolite drug that is easily accessible in LMICs, can be used intravaginally as adjuvant therapy following primary CIN2/3 treatment in WLWH to reduce CIN2/3 recurrence. While the safety, acceptability, and efficacy of self-administered 5-FU for cervical precancer treatment has been demonstrated in HICs, it has not been studied among WLWH in LMICs who bear the greatest burden of cervical cancer. Methods: We are conducting a Phase I pilot study investigating the feasibility of using 5-FU cream as an adjuvant, self-administered intravaginal therapy following cervical intraepithelial neoplasia grade 2/3 (CIN2/3) treatment among WLWH in Kenya (ClinicalTrials.gov NCT05362955). Twelve participants will be enrolled in this single-arm study. Participants will self-administer 2g of 5% 5-FU cream intravaginally every other week for eight applications. The primary objective is to determine safety, defined as the type, frequency, and severity of adverse events (AEs) using a standardized grading scale. The secondary objectives are uptake, tolerability, adherence, and acceptability. Results: There are no results at this time as this is an ongoing study. Discussion: To achieve the World Health Organization (WHO) 90/70/90 global cervical cancer elimination goals, which include 90% of women with cervical precancer adequately treated by 2030, it is essential to employ innovative and resource-appropriate strategies to improve cervical precancer treatment among WLWH. The use of 5-FU as adjuvant therapy following current screen & treat programs may be a feasible and scalable strategy to optimize outcomes in this high-risk group. This clinical trial will provide important feasibility data to inform future randomized efficacy trials in LMICs.
Blood pressure variability, central autonomic network dysfunction and cerebral small vessel disease in APOE4 carriers

Background: Increased blood pressure variability (BPV) is a risk factor for cerebral small vessel disease (CSVD) and neurodegeneration, independent of age and average blood pressure, particularly in apolipoprotein E4 (APOE4) carriers. However, it remains uncertain whether BPV elevation is a cause or a consequence of vascular brain injury, or to what degree injury to the central autonomic network (CAN) may contribute to BPV-associated risk in APOE4 carriers. Methods: Independently living older adults (n=70) with no history of stroke or dementia were recruited from the community and underwent 5 minutes of resting beat-to-beat blood pressure monitoring, genetic testing, and brain MRI. Resting BPV, APOE genotype, CSVD burden on brain MRI, and resting state CAN connectivity by fMRI were analyzed. Causal mediation and moderation analysis evaluated BPV and CAN effects on CSVD in APOE4 carriers (n=37) and non-carriers (n=33). Results: Higher BPV was associated with the presence and extent of CSVD in APOE4 carriers, but not non-carriers, independent of CAN connectivity (B= 18.92, P= .02), and CAN connectivity did not mediate the relationship between BPV and CSVD. In APOE4 carriers, CAN connectivity moderated the relationship between BPV and CSVD, whereby BPV effects on CSVD were greater in those with lower CAN connectivity (B= 36.43, P= .02). Conclusions: Older APOE4 carriers with higher beat-to-beat BPV exhibit more extensive CSVD, independent of average blood pressure, and the strength of CAN connectivity does not mediate these effects. Findings suggest increased BPV is more likely a cause, not a consequence, of CSVD. BPV is more strongly associated with CSVD in APOE4 carriers with lower rsCAN connectivity, suggesting CAN dysfunction and BPV elevation may have synergistic effects on CSVD. Further studies are warranted to understand the interplay between BPV and CAN function in APOE4 carriers.
Intravenous methadone in the management of acute postoperative pain in a chronic cancer pain patient: A case report and review of the literature

The current landscape of literature highlights that there is insufficient well‐powered and robust evidence to support the integration of intravenous methadone into current guidelines and frameworks in supporting the pain management of cancer patient with complex pain syndromes. However, there is preliminary evidence, both from the literature as well as this case study that highlights intravenous methadone may be efficaciously and safety used for the management of postoperative pain in cancer patients with chronic pain undergoing operative management. Further research is required to fully elucidate key considerations of integrating this medication into clinical practice including consideration into dosing, opioid conversion, tolerance, and safety.
Remarkable effects of infliximab on severe radiation-induced side effects in a patient with uterine cervical cancer: a case report

Pelvic radiotherapy is a powerful treatment for a broad range of cancers, including gynecological, prostate, rectal, and anal cancers. Despite improvements in the delivery of ionizing beams, damage to non-cancerous tissue can cause long-term effects that are potentially severe, affecting quality of life and daily function. There is an urgent need for new strategies to treat and reverse the side effects of pelvic radiotherapy without compromising the antitumor effect. A woman with severe radiation-induced intestinal side effects was treated with the tumor necrosis factor-alpha inhibitor infliximab with a dose of 3 mg/kg every 4 to 6 weeks. With infliximab treatment, a remarkable improvement in her bowel health was observed. The patient’s late bowel toxicity was reduced from Grade 2 to Grade 0 (RTOG/EORTC Late Radiation Morbidity Scale). Although it is necessary to proceed cautiously because of the risk of serious side effects from immunosuppressants, our case suggests that infliximab can be used to treat symptoms of chronic bowel dysfunction after radiotherapy.
Saproxylic beetles' morphological traits and higher trophic guilds indicate boreal forest naturalness

Abstract Forests contribute to numerous ecosystem functions and services and contain a large proportion of terrestrial biodiversity, but they are being negatively impaced by anthropogenic activities. Forests that have never been clear‐cut and have old growth characteristics, termed “near‐natural,” often harbor different and richer species assemblages than managed forests. Alternative management strategies may be able to balance the needs of biodiversity with the demands of forestry, but evaluation efforts are limited by the challenges of measuring biodiversity. Species richness is frequently used as a simple measure of biodiversity, but research indicates that it may not adequately capture community‐level changes. Alternatively, trait‐based measures of biodiversity may prove to be useful, but research is lacking. In this paper, we use a large dataset that includes 339 obligate saproxylic beetle species collected over a decade in the boreal region throughout southern Norway to: (1) establish if there is a difference in beetle community composition between near‐natural and managed forests; and (2) determine which measures of beetle biodiversity best indicate forest naturalness. We arranged the sites in an ordination space and tested for differences in community composition between these forest types. We also tested different measures of biodiversity to determine which were the most predictive of forest naturalness. We found a clear difference in community composition between near‐natural and managed forests. Additionally, three measures of biodiversity were most predictive of forest naturalness: proportional abundance of predators, community weighted mean (CWM) of wing length, and CWM of body roundness. The probability that a forest was near‐natural increased with the proportional abundance of predators but decreased with CWM wing length and body roundness. Although species richness was higher in near‐natural forests, the effect was not significant. Overall, our findings underscore the conservation value of near‐natural forests and highlight the potential of several measures of biodiversity for determining forest quality.
Benchmarking the nutrient composition and labelling practices of finger foods and snacks for older infants and young children across seven Southeast Asian countries

Abstract Ensuring consumption of nutrient‐dense, safe and appropriate complementary foods among older infants and young children (IYC) 6–36 months of age is critical for enabling optimal growth and development. The ubiquitous availability of and high demand for commercially packaged snack foods has culminated in a growing trend of snack food products specifically produced and promoted for older IYC. Commercially produced complementary foods (CPCF) that are finger foods/snacks often contain added sugars, excessive sodium content and high total sugar content, making them inappropriate for this young population. This study benchmarked the nutrient composition and labelling practices of CPCF finger foods/snacks available for purchase in seven countries in Southeast Asia. The study adapted a nutrient profiling model from the WHO Regional Office for Europe to determine the proportion of products suitable for promotion for older IYC. Of the total 606 products identified, 8.2% were automatically categorized as not suitable because they were confectionery items. Of the remaining 556 products assessed, over 85% failed to meet all nutrient composition requirements, with the presence of added sugars/sweeteners and excessive sodium and total sugar contents the primary reasons for failure. Products also demonstrated concerning labelling practices, with all of the products (98.6%) displaying an inappropriate claim on the label. These findings reveal major concerns with the nutrient composition and labelling practices of CPCF finger foods/snacks in the SEA region and should serve as an alarm bell for regulatory action. National binding legal measures, such as mandatory standards for composition and labelling are urgently needed.
Generation and distortion of Rb/Sr whole-rock isochrons; effects of metamorphism and alteration

The Rb/Sr method is used for dating both rocks and minerals. Aliquots of a homogenized whole rock are called whole-rock samples. Two requirements have to be met for meaningful whole-rock isochrons: identical initial Sr ratios for all samples at the time of formation, and closed system conditions for the Rb/Sr ratio and Sr isotopic composition. Whole-rock isochrons especially those of metamorphic rocks may be disturbed. This study summarizes current knowledge on relevant problems, Magmatic processes generally produce initial isotopic homogeneity. However, heterogeneous isotopic composition of Sr is usually found in rocks derived from crustal-anatectic melts and hybrid magmas. Isotopic homogenization may also be the result of metamorphic overprinting. Greenschist-facies metamorphism, promoted by microtectonism in the presence of an abundant aqueous phase, may cause isotopic adjustments to take place over distances of hundreds of meters. On the other hand, under conditions of amphibolite facies metamorphism isotopic homogenization may be restricted to only a few millimeters or centimeters. Alteration of rocks may occur either by shallow (cold) or by intracrustal (hot) hydrous interaction. Sr-loss from rock specimens is observed in many places. Losses of mainly non-radiogenic Sr isotopes may result in the original age information being preserved. Losses of radiogenic 87 Sr may locally be proportional to the Rb/Sr ratios, thus preserving linear arrays of the analytical data in an isochron diagram. Such apparent isochrons are lines with a decreased slope. However, even severely altered rock samples will yield the real age of an intrusion or a phase of metamorphism if the chemical attack took place immediately after their formation. For precise dating the boundary conditions of the Rb/Sr whole-rock dating method rarely appear to be fulfilled. Nevertheless, it seems noteworthy that all reported Rb/Sr ages from altered rocks are lower than ages determined on fresh samples from the same rock. Therefore altered rock samples may yield minimum Rb/Sr ages