Miracle-dz/UniFAR-FTUs huggingface dataset:
High ratio of monocytes to high-density lipoprotein is associated with hemorrhagic transformation in acute ischemic stroke patients on intravenous thrombolysis

Background Hemorrhagic transformation (HT) is a frequent, serious complication in acute ischemic stroke patients on intravenous thrombolysis. Here we investigated whether risk of HT is associated with the ratio of monocyte count to high-density lipoprotein level (MHR). Materials and methods Medical records were retrospectively examined for consecutive patients with acute ischemic stroke who received thrombolytic therapy. HT was diagnosed by computed tomography at 24–36 h after therapy. Potential association between MHR and HT was examined using logistic regression. Results A total of 340 patients were analyzed, and their median MHR was 0.44 (0.31–0.59). MHR was higher in the 51 patients (15.0%) with HT than in those who did not suffer HT (0.53 vs. 0.42, P = 0.001). Multivariate logistic regression showed that, after adjusting for potential confounders, MHR was an independent risk factor for HT (OR 7.50, 95% CI 1.64 to 34.35, P = 0.009). Risk of HT was significantly higher among patients whose MHR fell in the third quartile (0.42–0.53) and the fourth quartile (> 0.53) than among those with MHR in the first quartile (< 0.31; OR 3.53, 95% CI 1.11 to 11.20, P = 0.032; OR 4.79, 95% CI 1.49 to 15.42, P = 0.009). Conclusion High MHR may be independently associated with higher risk of HT in patients with acute ischemic stroke on intravenous thrombolysis.
A homozygous variant in the GPIHBP1 gene in a child with severe hypertriglyceridemia and a systematic literature review

Background: Due to nonspecific symptoms, rare dyslipidaemias are frequently misdiagnosed, overlooked, and undertreated, leading to increased risk for severe cardiovascular disease, pancreatitis and/or multiple organ failures before diagnosis. Better guidelines for the recognition and early diagnosis of rare dyslipidaemias are urgently required. Methods: Genomic DNA was isolated from blood samples of a Pakistani paediatric patient with hypertriglyceridemia, and from his parents and siblings. Next-generation sequencing (NGS) was performed, and an expanded dyslipidaemia panel was employed for genetic analysis. Results: The NGS revealed the presence of a homozygous missense pathogenic variant c.230G>A (NM_178172.6) in exon 3 of the GPIHBP1 (glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1) gene resulting in amino acid change p.Cys77Tyr (NP_835466.2). The patient was 5.5 years old at the time of genetic diagnosis. The maximal total cholesterol and triglyceride levels were measured at the age of 10 months (850.7 mg/dl, 22.0 mmol/L and 5,137 mg/dl, 58.0 mmol/L, respectively). The patient had cholesterol deposits at the hard palate, eruptive xanthomas, lethargy, poor appetite, and mild splenomegaly. Both parents and sister were heterozygous for the familial variant in the GPIHBP1 gene. Moreover, in the systematic review, we present 62 patients with pathogenic variants in the GPIHBP1 gene and clinical findings, associated with hyperlipoproteinemia. Conclusion: In a child with severe hypertriglyceridemia, we identified a pathogenic variant in the GPIHBP1 gene causing hyperlipoproteinemia (type 1D). In cases of severe elevations of plasma cholesterol and/or triglycerides genetic testing for rare dyslipidaemias should be performed as soon as possible for optimal therapy and patient management.
Modulation of Leukocyte Subsets Mobilization in Response to Exercise by Water Immersion Recovery

Purpose: To investigate the effect of different water immersion temperatures on the kinetics of blood markers of skeletal muscle damage and the main leukocyte subpopulations. Methods: Eleven recreationally trained young men participated in four experimental sessions consisting of unilateral eccentric knee flexion and 90 min of treadmill running at 70% of peak oxygen uptake, followed by 15 min of water immersion recovery at 15, 28 or 38°C. In the control condition participants remained seated at room temperature. Four hours after exercise recovery, participants completed a performance test. Blood samples were obtained before and immediately after exercise, after immersion, immediately before and after the performance test and 24 h after exercise. The number of leukocyte populations and the percentage of lymphocyte and monocytes subsets, as well as the serum activity of creatine kinase and aspartate aminotransferase were determined. Results: Leukocytosis and increase in blood markers of skeletal muscle damage were observed after the exercise. Magnitude effect analysis indicated that post-exercise hot-water immersion likely reduced the exercise-induced lymphocytosis and monocytosis. Despite reduced monocyte count, recovery by 38°C immersion, as well as 28°C, likely increased the percentage of non-classical monocytes in the blood. The percentage of CD25+ cells in the CD4 T cell subpopulation was possibly lower after immersion in water at 28 and 15°C. No effect of recovery by water immersion was observed for serum levels of creatine kinase and aspartate aminotransferase. Conclusions: Recovery by hot-water immersion likely attenuated the leukocytosis and increased the mobilization of non-classical monocytes induced by a single session of exercise combining resistance and endurance exercises, despite no effect of water immersion on markers of skeletal muscle damage. The monocyte response mediated by hot water immersion may lead to the improvement of the inflammatory response evoked by exercise in the skeletal muscle.
Validity of Broselow tape for estimating the weight of children in pediatric emergency: A cross-sectional study

Objective To assess the validity of the Broselow tape in estimating the weight of Chinese children in pediatric emergency. Methods A cross-sectional study was conducted in the emergency department of the Children's Hospital of Zhejiang University School of Medicine (Hangzhou, Zhejiang Province, China) in March 2022. Broselow tape was used to estimate weight and its validity was compared with the advanced child life support (APLS) method. Results The study included 442 children (mean age: 48 months; male-to-female ratio: 1.13:1). The < 10, 10–19 and > 19-kg groups included 44, 257, and 141 children, respectively. The color concordance rates of the Broselow tape-estimated weight in the three groups were 56.8, 57.2, and 68.1%, respectively. The percentage of weight estimations within 10% of actual weight were 65.8% (59.1, 65.8, and 68.1% for the <10, 10–19 and > 19-kg groups, respectively) and 44.8% (40.9, 50.6, and 35.5% for the < 10, 10–19 and > 19-kg groups, respectively) using the Broselow tape and the APLS method, respectively. The correlation between the Broselow tape estimated weight and actual weight was r = 0.931 (P < 0.0001, 95% CI: 0.918–0.943), while the correlation between actual weight and the APLS method calculated weight was r = 0.883 (P < 0.0001, 95% CI: 0.861–0.902). The mean percentage error using the Broselow tape was 1.0 ± 12.0% (P < 0.001 vs. −7.2 ± 17.2% of the APLS method). Conclusion The Broselow tape may be an available method for predicting the weights of Chinese children in pediatric emergency.
Distribution and microbial degradation of dissolved organic carbon in the northern South China Sea

Dissolved organic carbon (DOC) is the largest reduced carbon pool in the ocean, and it plays significant roles not only in the ocean carbon cycle but also in the control of many biogeochemical processes in the ocean. We present the concentrations and distribution of DOC in the northern South China Sea (SCS) and western North Pacific (NP) in the spring and summer seasons of 2015-2016 and 2019. Laboratory incubation bioassay experiments were also conducted to determine the microbiological respiration of DOC. In the SCS, the concentrations of DOC varied within a range of 38-95 μM, and the large spatial variations in DOC in the upper 100 m depth were influenced by a combination of factors, including primary production, terrestrial inputs from the Pearl River and the intrusion of the Kuroshio Current. The mesopelagic DOC distribution in the northern SCS basin was largely influenced by the physical mixing of upwelled deep water; however, biological processes were estimated to account for 6-20% of the modulation in DOC concentrations. Compared with the deep DOC levels in open ocean areas, a slightly excessive DOC concentration (~ 3-4 μM) was observed in the deep water of the SCS basin. Approximately 10-20% of the DOC was consumed by mesopelagic and/or deep water bacteria in the incubation bioassay experiments, and labile DOC was preferentially respired, resulting in decreased δ13C and Δ14C values of DOC.
Retrospective assessment of metabolic syndrome components in early adult life on vegetarian dietary status

Background Metabolic syndrome (MetS) encompasses several clinical presentations that include truncal obesity and insulin resistance at its core. MetS afflicts 23% of the adult US population, increasing their risk of diabetes and cardiovascular disease. Many studies have indicated the importance of a vegetarian diet in improving overall health and more specifically MetS components. Unfortunately, these findings have been inconsistent and cannot be extended to examine effects on MetS incidence in the younger adult population. Objective This study aimed to conduct a retrospective analysis of a vegetarian vs. non-vegetarian dietary status in young adults (age 18–24) based on MetS components in later adulthood (age 20–30). This study focuses on elucidating any relationship between a vegetarian diet and MetS components of central obesity, hypertension, and hyperlipidemia. Methods: Waves 3 and 4 data were acquired from AddHealth. One-to-one propensity score matched vegetarians to non-vegetarians in a cohort of 535 women and 159 men. Logistical regression assessed the relationship between vegetarian status and MetS components, including truncal obesity (cm), hypertension (normal, pre-HT, HT1, and HT2), and hyperlipidemia (high and low). Results MetS components from ages 20 to 30 are not associated with vegetarian dietary status. Truncal obesity [N = 694; M = 92.82 cm; OR 0.999; p = 0.893; 95% CI (0.980, 1.017)]; hypertension [N = 694; OR 0.949; p = 0.638; 95% CI (0.764, 1.179)]; hyperlipidemia [N = 694; OR 0.840; p = 0.581; 95% CI (0.453, 1.559)]. Conclusion Current study results were consistent with previous findings suggesting that consumption of a vegetarian diet cannot be directly linked to MetS outcomes. However, further investigation should be completed as MetS is a risk factor for several chronic diseases.
A nomogram to predict lateral lymph node metastases in lateral neck in patients with medullary thyroid cancer

Background Medullary thyroid cancer (MTC) can only be cured by surgery, but the management of lateral lymph nodes is controversial, especially for patients with cN0+cN1a. To address this challenge, we developed a multivariate logistic regression model to predict lateral lymph node metastases (LNM). Methods We retrospectively collected clinical data from 124 consecutive MTC patients who underwent initial surgery at our institution. The data of 82 patients (from 2010 to 2018) and 42 patients (from January 2019 to November 2019) were used as the training set for building the model and as the test set for validating the model, respectively. Results In the training group, the multivariate analyses indicated that male and MTC patients with higher preoperative basal calcitonin levels were more likely to have lateral LNM (P = 0.007 and 0.005, respectively). Multifocal lesions and suspected lateral LNM in preoperative ultrasound (US) were independent risk factors (P = 0.032 and 0.002, respectively). The identified risk factors were incorporated into a multivariate logistic regression model to generate the nomogram, which showed good discrimination (C-index = 0.963, 95% confidence interval [CI]: 0.9286–0.9972). Our model was validated with an excellent result in the test set and even superior to the training set (C-index = 0.964, 95% CI: 0.9121–1.000). Conclusion Higher preoperative basal calcitonin level, male sex, multifocal lesions, and lateral lymph node involvement suspicion on US are risk factors for lateral LNM. Our model and nomogram will objectively and accurately predict lateral LNM in patients with MTC.
Benchmark and Result Analysis of 3D Reconstruction with Structured Light Scanning

: Computer vision based 3D Reconstruction is gaining importance because of its better visualization and accurate depth measurement. Over the years, various passive and active 3D reconstruction methods were devised to exploit the explicit information about the scene or objects in the scene. Active methods have the advantage of producing accurate 3D models at high speed. In this paper, an active method of 3D reconstruction is performed by structured light scanning using a hardware setup consisting of two cameras and a projector and is implemented using OpenCV and Python. The results obtained are compared with the standard results obtained using Matlab and Visual C++ and the benchmark results are tabulated and the best solution for implementing 3D reconstruction is determined. The benchmark results include the CPU, RAM and the Processor through which the minimum system requirement is calculated.
A Classiﬁcation Method to Select a Mashup Creating Tool Based on Prior Knowledge of the End-User

—Over the years, several tools and frameworks have appeared with the aim to facilitate the creation of mashups for the end user. These tools aim to integrate semantic and nonsemantic information available on the Web. However, not all users have the necessary technological knowledge to use them interchangeably. In this article, we propose a two stage classiﬁcation for this set of tools that will allow users to select the most suitable tool based on their previous knowledge. In the ﬁrst stage, we focus on the interface for the construction of the mashup provided by the system, enabling users to choose the technology they feel most comfortable with. In the second stage, a set of criteria for the choice of a particular tool are presented.
The study of autoimmune orbital inflammation role in the development of ocular hypertension

PURPOSE: To study the role of autoimmune inflammation of the orbit in the development of ocular hypertension in patients with endocrine ophthalmopathy (EOP) and Graves’ disease (GD). METHODS: 317 patients with GD and EOP were included in the study. All patients underwent endocrine and ophthalmological examination. Ophthalmologic study included visometry, perimetry, tonometry, ophthalmoscopy and exophthalmometry. Orbit structure was examined with the help of multispiral computed tomography. Endocrinological study combined measuring the levels of thyroid hormones, TSH and rTSH antibodies with thyroid ultrasound. The dynamic study was carried out during a one-year period of thyroid diseases (surgical and radioiodine therapy) and endocrine ophthalmopathy (38 patients, 76 eyes) treatment. Patients were monitored every 6 months or more often in cases of necessity (in patients with a highly active progressive ophthalmopathy). RESULTS: The disease activity score estimation in patients with ophthalmopathy revealed a close, direct and statistically significant connection between the ocular tonus and the inflammation activity index. The orbital inflammation activity had a direct correlation with the level of IOP. The distribution frequency analysis of different IOP indices in patient groups with low-, moderate-, and highly active forms of EOP showed that ocular hypertension develops more rarely in patients with low inflammation activity than in patients with a highly active inflammatory process (e.g. 3.3% versus 50%, p <0.001). In other words, half of the eyes with highly active forms of EOP had ocular hypertension (>25.0 mm Hg) on the first visit. In general, the ocular hypertension group was represented by 86.1% patients with orbital inflammation clinical activity score (CAS)≥3. The treatment with glucocorticoids led to a reliable decrease in the ocular tonus. Maximum therapeutic effect was achieved by a combination of intravenous pulse therapy and retrobulbar injections. CONCLUSION: A statistically significant direct correlation was revealed between the ocular tonus and inflammatory activity index. The endocrine disease treatment resulted in both the decrease in inflammatory activity in the orbit and a hypotensive effect.
Studies on pollen quality and quantity, stigma receptivity, pollination and fruit set in raspberry ( Rubus paniculatus S.) wild species of Garhwal Himalaya, Uttarakhand,

Raspberry wild species ( Rubus paniculatus S.) of Garhwal Himalaya was selected to determine the pollen quality and quantity, pollination and fruit set under the hilly regions of Garhwal Himalaya. The raspberry produced 1,59,012 number of pollens per flower and exhibited maximum pollen grain size (length x width) of 35.87 x 17.73 µ in dry conditions and 35.44 µ x 16.52 µ in glycerine. The pollen viability was 73.33% and its longevity was extended up to 7th day. Pollens showed delayed germination (24 hours), the treatment T 16 (25% Sucrose + 5ppm Gibberellic acid) showed maximum pollen germination 9.66%, 37.82% and 52.34% and pollen tube length of 88.05 µ, 99.18 µ and 135.22 µ, at 24, 48 and 78 hours after planting. Stigma receptivity was highest on the day of anthesis, pollination studies indicated that maximum fruit set was observed on natural pollination (cross pollination) than any other method of pollination. Interspecific pollination of Rubus paniculatus S. with Rubus niveus T. and Rubus macilentus C. revealed that Rubus paniculatus S. is good male parent with better fruit set, when it was used as female parent, did not set any fruits. studies,
BRIGHT DEBRIS DISK CANDIDATES DETECTED WITH THE AKARI/FAR-INFRARED SURVEYOR

We cross-correlate the Hipparcos main-sequence star catalog with the AKARI/FIS catalog and identify 136 stars (at >90% reliability) with far-infrared detections in at least one band. After rejecting 57 stars classified as young stellar objects, Be stars and other type stars with known dust disks or with potential contaminations, and 4 stars without infrared excess emission, we obtain a sample of 75 candidate stars with debris disks. Stars in our sample cover spectral types from B to K with most being early types. This represents a unique sample of luminous debris disks that derived uniformly from an all-sky survey with a spatial resolution factor of four better than the previous such survey by IRAS. Moreover, by collecting the infrared photometric data from other public archives, almost three-quarters of them have infrared excesses in more than one band, allowing an estimate of the dust temperatures. We fit the blackbody model to the broadband spectral energy distribution of these stars to derive the statistical distribution of the disk parameters. Four B stars with excesses in four or more bands require a double blackbody model, with the high one around 100 or 200 K and the low one around 40–50 K.
NSS_A_254449 603..613

1Department of Anesthesiology, The First Hospital of China Medical University, Shenyang, People’s Republic of China; 2Department of Anesthesiology, The First Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China Purpose: As tau pathology is involved in impaired postoperative learning and memory in rats, we attempted to identify the possible mechanisms by which tau pathology affects postoperative sleep deprivation. Methods: Adult male Sprague-Dawley rats were randomly assigned into six groups as follows: the Control group, Anaesthesia group, Surgery group, Sleep deprivation (SD) group: 24-h SD with the modified multiple platform method (MMPM), Anaesthesia and SD (ASD) group, and Surgery and SD (SSD) group. Tau396 and FOXQ1 protein expression levels in the hippocampal neurons of all groups were analysed. Changes following co-culture of hippocampal neurons with IL-6 were detected by flow cytometry. Results: Twenty-four hours of acute SD decreased the error scores on postoperative day 5 in the ASD and SSD groups compared with the Anaesthesia and Surgery groups. Compared with the tau levels in the Control group, tau levels in the Anaesthesia and Surgery groups were increased, but SD decreased the expression of tau in the ASD and SSD groups. The expression levels of tau and FOXQ1 were inversely regulated. When hippocampal neurons were co-cultured with IL-6, the same changes were observed. Conclusion: Postoperative 24-h acute SD improves learning and memory through inhibition of tau phosphorylation and increases IL-6-induced expression of FOXQ1 in the hippocampal neurons of splenectomized rats.
Institutional Knowledge at Singapore Management University Institutional Knowledge at Singapore Management University Contracting over Prices Contracting over Prices

We deﬁne a solution concept, perfectly contracted equilibrium, for an intertemporal exchange economy where agents are simultaneously price takers in spot commodity markets while engaging in eﬃcient, non-Walrasian contracting over future prices. Without requiring that agents have perfect foresight, we show that perfectly contracted equilibrium outcomes are a subset of Pareto optimal allocations. It is a robust possibility for perfectly contracted equilibrium outcomes to diﬀer from Arrow-Debreu equilibrium outcomes. We show that both centralized banking and retrading with bilateral contracting can lead to perfectly contracted equilibria.
role of periooperative rehabilitation in patients with abdominal aortic aneurysm in the

(50.00%) considered the exercises to deal with the surgical wound to be the most important. Nursing staff statistically more often (59.21%) than doctors (26.92%) pointed to the need to continue rehabilitation in the outpatient period. Conclusions: Perioperative rehabilitation carried out in patients after TAB is an important element of treatment. It should be implemented already before the operation and continued at the outpatient stage, when the patient leaves the hospital. Employment at full-time physical therapist wards would facilitate the implementation of a comprehensive rehabilitation process and the significance would shorten the period of patient recovery after surgery.
Impedance Spectroscopy Studies on Steatite with B2O3 Ceramics Materials from Algerian Palygorskite

B2O3 was used to reduce the sintering temperature of steatite (named MSB) dielectric ceramics. Electrical properties of this composition have been studied using impedance spectroscopic method to get better understanding of the electrical conduction, dielectric relaxation mechanism, and microstructure –electrical properties relationship of the materials as a function of temperature and frequency. These samples were prepared by a solid-state reaction technique and their single phase formation was confirmed by the X-ray diffraction technique. Dielectric and complex impedance spectroscopic studies were carried out in a wide frequency (102-106 Hz) and temperature (30-500C) range. The dielectric constants decrease with increasing frequency for each sample, and then stabilize at frequencies lower than 100 kHz. The dielectric constant increases with the addition of B2O3. The nature of frequency dependence of ac conductivity of MSB follows the Jonscher power law and calculated DC conductivity follows Arrhinius behavior. The Nyquist plot (Z′′ vs Zʹ) revealed the presence only of the grain boundary effect from 350C onwards. The occurrence of single arc in the complex modulus spectrum of MSB compositions confirms the single-phase characteristics, and also confirms the presence of non-Debye type of multiple relaxations in the material.