Miracle-dz/UniFAR-FTUs huggingface dataset:
Extended ammonia observations towards the integral-shaped filament

Context. Recent observations suggest a scenario in which filamentary structures in the interstellar medium represent the first step towards clumps/cores and eventually star formation. The densest filaments would then fragment into prestellar cores owing to gravitational instability. Aims. We seek to understand the roles filamentary structures play in high-mass star formation. Methods. We mapped the integral-shaped filament (ISF) located at the northern end of the Orion A molecular cloud in NH3 (1, 1) and (2, 2). The observations were made using the 25 m radio telescope operated by the Xinjiang Astronomical Observatory, Chinese Academy of Sciences. The whole filamentary structure, about 1.2° × 0.6°, is uniformly and fully sampled. We investigate the morphology, fragmentation, kinematics, and temperature properties in this region. Results. We find that the morphology revealed by the map of velocity-integrated intensity of the NH3 (1, 1) line is closely associated with the dust ridge revealed by the Herschel Space Observatory. We identify 6 “lumps” related to the well known OMC-1 to 5 and 11 “sub-clumps” within the map. The clumps and sub-clumps are separated not randomly but in roughly equal intervals along the ISF. The average spacing of clumps is 11.30′ ± 1.31′ (1.36 ± 0.16 pc) and the average spacing of sub-clumps is 7.18′ ± 1.19′ (0.86 ± 0.14 pc). These spacings agree well with the predicted values of the thermal (0.86 pc) and turbulent sausage instability (1.43 pc) by adopting a cylindric geometry of the ISF with an inclination of 60° with respect to the line of sight. We also find a velocity gradient of about 0.6 km s−1 pc−1 that runs along the ISF which likely arises from an overall rotation of the Orion A molecular cloud. The inferred ratio between rotational and gravitational energy is well below unity. Furthermore, fluctuations are seen in the centroid velocity diagram along the ISF. The OMC-1 to 5 clouds are located close to the local extrema of the fluctuations, which suggests that there exist gas flows associated with these clumps in the ISF. The derived NH3 (1, 1) and (2, 2) rotation temperatures in the OMC-1 are about 30–40 K while lower temperatures (below 20 K) are obtained in the northern and southern parts of the ISF. In OMC-2, OMC-3, and the northern part of OMC-4, we find higher and lower temperatures at the boundaries and in the interior, respectively.
Prevalence, antibiotic spectrum and genetic relatedness in thermophilic Campylobacter species from poultry production environment of Punjab

Campylobacter is responsible for human gastroenteritis worldwide. C. jejuni and C. coli are most frequently encountered in animals, birds and man, but mainly C. jejuni is particularly adapted to poultry. The disease in humans ranges from gastroenteritis to Guillain-Barre Syndrome. To know the status of Campylobacter species especially, C. jejuni in poultry environment in Punjab, 342 poultry fecal samples (228 from layers and 114 from broilers) were collected from 30 poultry farms of Punjab. Additionally, 27 fecal samples from poultry farm workers were also collected. Analysis of the samples revealed that 21 (6.14%) fecal samples (from poultry farm) and two (7.41%) from farm workers were positive for Campylobacters based on cultural and molecular detection. Out of 23 Campylobacter positive isolates, 19 (80.95%) were C. jejuni and 4 (19.04%) were C. coli. Antibiotic resistance in the isolates was low. The majority of the isolates were sensitive to macrolide and quinolone class of antibiotics which are important for the treatment of campylobacteriosis. Pulse Field Gel Electrophoresis (PFGE) showed high genetic diversity among C. jejuni, however, it was limited in C. coli isolates. Poultry production in Punjab poses a potential risk of campylobacteriosis. However, antibiotic resistance in the isolates was low.
Quantum Algorithms for Computational Physics: Volume 3 of Lattice Gas Dynamics

Abstract : This report is divided into two tracks, an introductory track and a technical track. The introductory track includes a general introduction and background, introductions to two types of analog (and parallel) quantum computing, and an overview oriented conclusion. The technical track includes sections on quantum memory, conservative quantum logic, and quantum algorithm types, including quantum algorithms for the Dirac and Schroedinger quantum mechanical wave equations, the mesoscopic scale quantum Boltzmann equation, and the quantum algorithms for the diffusion equation, Burgers equation, magnetohydrodynamic Burgers equations, and the Navier-Stokes fluid equation.
On a connection between the reliability of multi-channel systems and the notion of controlled-invariance entropy

The purpose of this note is to establish a connection between the problem of reliability (when there is an intermittent control-input channel failure that may occur between actuators, controllers and/or sensors in the system) and the notion of controlled-invariance entropy of a multi-channel system (with respect to a subset of control-input channels and/or a class of control functions). We remark that such a connection could be used for assessing the reliability (or the vulnerability) of the system, when some of these control-input channels are compromised with an external "malicious" agent that may try to prevent the system from achieving more of its goal (such as from attaining invariance of a given compact state and/or output subspace).
An Application of the Global ILC Algorithm over Large Angular Scales to Estimate the CMB Posterior Using Gibbs Sampling

In this work, we formalize a new technique to investigate the joint posterior density of the cosmic microwave background (CMB) signal and its theoretical angular power spectrum given the observed data, using the global internal-linear-combination method first proposed in a paper by Sudevan & Saha in 2017. We implement the method on low-resolution CMB maps observed by the Wilkinson Microwave Anisotropy Probe (WMAP) and the Planck satellite missions, using Gibbs sampling, assuming that the detector noise is negligible on large angular scales of the sky. The main products of our analysis are a best-fit cleaned CMB map and its theoretical angular power spectrum, along with their error estimates. We validate the method by performing Monte Carlo simulations that include realistic foreground models and noise levels consistent with WMAP and Planck observations. Our method has a unique advantage: the posterior density is obtained without any need to explicitly model foreground components. Second, the power spectrum results with the error estimates can be directly used for cosmological parameter estimations.
Antifibrotic TSG-6 Expression Is Synergistically Increased in Both Cells during Coculture of Mesenchymal Stem Cells and Macrophages via the JAK/STAT Signaling Pathway

The pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-1β upregulate TNF-α-stimulated gene 6 (TSG-6); however, current knowledge about the optimal conditions for TSG-6 expression in mesenchymal stem cells (MSCs) is limited. Here, we investigated whether TSG-6 expression varies depending on the polarization state of macrophages co-cultured with adipose tissue-derived stem cells (ASCs) and analyzed the optimal conditions for TSG-6 expression in ASCs. TSG-6 expression increased in ASCs co-cultured with M0, M1, and M2 macrophages indirectly; among them, M1 macrophages resulted in the highest increase in TSG-6 expression in ASCs. TSG-6 expression in ASCs dramatically increased by combination (but not single) treatment of TNF-α, IL-1β, interferon-gamma (IFN-γ), and lipopolysaccharide (LPS). In addition, phosphorylation of signal transducer and activator of transcription (STAT) 1/3 was observed in response to IFN-γ and LPS treatment but not TNF-α and/or IL-1β. STAT1/3 activation synergistically increased TNF-α/IL-1β-dependent TSG-6 expression, and JAK inhibitors suppressed TSG-6 expression both in ASCs and macrophages. In LX-2 hepatic stellate cells, TSG-6 inhibited TGF-β-induced Smad3 phosphorylation, resulting in decreased α-smooth muscle actin (SMA) expression. Moreover, fibrotic activities of LX-2 cells induced by TGF-β were dramatically decreased after indirect co-culture with ASCs and M1 macrophages. These results suggest that a comprehensive inflammatory microenvironment may play an important role in determining the therapeutic properties of ASCs by increasing TSG-6 expression through STAT1/3 activation.
Radioseismology as a new method of investigations of meteor streams on the moon and planets

Radioseismology is based on registration and interpretation of radio emission of seismic origin. Non-thermal radio emission of the Moon was detectedat 13 and 21 cm on July 30 - August 2, 1999. Strong oscillations of the non-thermal lunar radio flux at 25 mm were detected during the leonid meteor shower on November 17-18, 2000. The time of maxima of oscillations does not contradict theoretical predictions about the existence of three maxima of the Leonid shower on the Moon. These results can be explained as the detection of lunar radio emission of seismic origin caused by meteoroid impacts. The implications of the radioseismic method for determination of the intensity of meteor streams on the Moon are described.
Recent Progress in Biosensors for Detection of Tumor Biomarkers

Cancer is a leading cause of death worldwide, with an increasing mortality rate over the past years. The early detection of cancer contributes to early diagnosis and subsequent treatment. How to detect early cancer has become one of the hot research directions of cancer. Tumor biomarkers, biochemical parameters for reflecting cancer occurrence and progression have caused much attention in cancer early detection. Due to high sensitivity, convenience and low cost, biosensors have been largely developed to detect tumor biomarkers. This review describes the application of various biosensors in detecting tumor markers. Firstly, several typical tumor makers, such as neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), prostate-specific antigen (PSA), squamous cell carcinoma antigen (SCCA), carbohydrate, antigen19-9 (CA19-9) and tumor suppressor p53 (TP53), which may be helpful for early cancer detection in the clinic, are briefly described. Then, various biosensors, mainly focusing on electrochemical biosensors, optical biosensors, photoelectrochemical biosensors, piezoelectric biosensors and aptamer sensors, are discussed. Specifically, the operation principles of biosensors, nanomaterials used in biosensors and the application of biosensors in tumor marker detection have been comprehensively reviewed and provided. Lastly, the challenges and prospects for developing effective biosensors for early cancer diagnosis are discussed.
Microstructural and Thermo-Mechanical Characterization of Furfurylated Douglas Fir

Fast-growing wood has become a major source of materials for the wood industry in recent years, but defects have limited its use. Therefore, modification is urgently needed for the more efficient application of wood products. In this study, a 30 to 50% solution of furfuryl alcohol (FA) was impregnated into Douglas fir sapwood. The microstructure and thermal properties of the specimens before and after furfurylation were evaluated by different techniques. The weight percentage gain (WPG) of modified wood increased up to 22.97%, with the polymerized FA distributed in cell lumens and cell walls, as well as chemically bound to wood components. The polyfurfuryl alcohol (PFA) was mainly located in the tracheids, ray parenchyma cells, and resin canals. In addition, the furfurylated cell walls were greatly thickened. Raman spectra showed that modified wood had significant background fluorescence that covered other peaks. Differential Scanning Calorimetry analysis revealed that the cross-linking reaction between FA and wood changed the shape of curves, with no endothermic or exothermic peaks within the programmed temperature. Moreover, Thermogravimetry and Dynamic Mechanical Analysis results both confirmed that the furfurylation increased the thermal stability of Douglas fir. The percentage of the final mass loss of untreated specimen was 80.11%, while the highest one of furfurylated specimen was 78.15%, and it gradually decreased with increasing FA concentration. The storage modulus (E′) and loss modulus (E″) of the furfurylated wood were both lower, and the damping factor (tan δ) was higher than the untreated one. When the temperature reaches about 75 °C, the untreated specimen began to soften and deform. At 90 °C, it fractured completely while the furfurylatedone remained stable. This study demonstrated that furfurylation can improve wood properties and elongate its service life.
Phase diagrams from single molecular dynamics simulations

From the Ising model and the Lennard-Jones fluid, to water and the iron-carbon system, phase diagrams are an indispensable tool to understand phase equilibria. In spite of the effort of the simulation community the calculation of a large portion of a phase diagram using computer simulation is still today a significant challenge. Here we propose a method to calculate phase diagrams involving liquid and solid phases by the reversible transformation of the liquid and the solid. To this end we introduce an order parameter that breaks the rotational symmetry and we leverage our recently introduced method to sample the multithermal-multibaric ensemble. In this way in a single molecular dynamics simulation we are able to compute the liquid-solid coexistence line for entire regions of the temperature and pressure phase diagram. We apply our approach to the bcc-liquid phase diagram of sodium and the fcc-bcc-liquid phase diagram of aluminum.
FeSe(en)0.3 - Separated FeSe layers with stripe-type crystal structure by intercalation of neutral spacer molecules

Solvothermal intercalation of ethylenediamine molecules into FeSe separates the layers by 1078 pm and creates a different stacking. FeSe(en)0.3 is not superconducting although each layer exhibits the stripe-type crystal structure and the Fermi surface topology of superconducting FeSe. FeSe(en)0.3 requires electron-doping for high-Tc similar to monolayers of FeSe@SrTiO3, whose much higher Tc may arise from the proximity of the oxide surface.
CircRNAs in Tumor Radioresistance

Circular RNAs (circRNAs) are endogenous, non-coding RNAs, which are derived from host genes that are present in several species and can be involved in the progression of various diseases. circRNAs’ leading role is to act as RNA sponges. In recent years, the other roles of circRNAs have been discovered, such as regulating transcription and translation, regulating host genes, and even being translated into proteins. As some tumor cells are no longer radiosensitive, tumor radioresistance has since become a challenge in treating tumors. In recent years, circRNAs are differentially expressed in tumor cells and can be used as biological markers of tumors. In addition, circRNAs can regulate the radiosensitivity of tumors. Here, we list the mechanisms of circRNAs in glioma, nasopharyngeal carcinoma, and non-small cell lung cancer; further, these studies also provide new ideas for the purposes of eliminating radioresistance in tumors.
Regioselective Synthesis of 6-O-Acetyl Dieckol and Its Selective Cytotoxicity against Non-Small-Cell Lung Cancer Cells

Dieckol, a phlorotannin from Ecklonia cava, has shown potential for use as an anticancer agent that selectively kills cancer cells. However, it is necessary to amplify its potency without damaging its inherent safety in order to develop it as a competitive chemotherapeutic. Here, we explored the controlled O-acylations of dieckol. Acyl groups could be consistently introduced to the 6-O position of dieckol with a high regioselectivity, which was confirmed by NOESY, HMBC and HSQC spectroscopies. In cytotoxicity studies on the newly synthesized 6-O-acetyl, 6-O-benzoyl dieckols and previously synthesized 6-O-alkyl dieckols against A549 vs. normal cells, all of the derivatives showed low cytotoxicity in normal cells with an IC50 of 481–719 μM, and highly structure-dependent cytotoxicity in A549 cells with an IC50 of 7.02 (acetyl)−842.26 (benzyl) μM. The selectivity index also showed a large structure dependency in the range of 0.67 (benzyl)–68.58 (acetyl). An analysis of the structure–activity relationship indicated that the activity was dramatically reduced in the presence of a benzene ring and was highly increased in the presence of small polar substituents. Conclusions: Controlled mono-O-modifications of dieckol could be a powerful tool to enhance the anticancer activity of dieckol, thus contributing to the development strategy for dieckol-based chemotherapeutics.
Probability distribution functions of gas surface density in M 33

Aims. We examine the interstellar medium (ISM) of M 33 to unveil fingerprints of self-gravitating gas clouds throughout the star-forming disk. Methods. The probability distribution functions (PDFs) for atomic, molecular, and total gas surface densities are determined at a resolution of about 50 pc over regions that share coherent morphological properties and considering cloud samples at different evolutionary stages in the star formation cycle. Results. Most of the total gas PDFs are well fit by log-normal functions whose width decreases radially outward. Because the HI velocity dispersion is approximately constant throughout the disk, the decrease in PDF width is consistent with a lower Mach number for the turbulent ISM at large galactocentric radii where a higher fraction of HI is in the warm phase. The atomic gas is found mostly at face-on column densities below NHlim = 2.5 × 1021 cm−2, with small radial variations of NHlim. The molecular gas PDFs do not show strong deviations from log-normal functions in the central region where molecular fractions are high. Here the high pressure and rate of star formation shapes the PDF as a log-normal function, dispersing self-gravitating complexes with intense feedback at all column densities that are spatially resolved. Power-law PDFs for the molecules are found near and above NHlim, in the southern spiral arm and in a continuous dense filament extending at larger galactocentric radii. In the filament nearly half of the molecular gas departs from a log-normal PDF, and power laws are also observed in pre-star-forming molecular complexes. The slope of the power law is between −1 and −2. This slope, combined with maps showing where the different parts of the power law PDFs come from, suggests a power-law stratification of the density within molecular cloud complexes, in agreement with the dominance of self-gravity.
Second harmonic spectroscopy to optically detect valley polarization in 2D materials

Valley polarization (VP), an induced imbalance in the populations of a multi-valley electronic system, allows emission of second harmonic (SH) light even in centrosymmetric crystals such as graphene. Whereas in systems such as MoS2 or BN this adds to their intrinsic quadratic response, SH generation in a multi-valley inversion-symmetric crystal can provide a direct measure of valley polarization. By computing the nonlinear response and characterizing theoretically the respective SH as a function of polarization, temperature, electron density, and degree of VP, we demonstrate the possibility of disentangling and individually quantifying the intrinsic and valley contributions to the SH. A specific experimental setup is proposed to obtain direct quantitative information about the degree of VP and allow its remote mapping. This approach could prove useful for direct, contactless, real-space monitoring of valley injection and other applications of valley transport and valleytronics.
Band gaps of primary metallic carbon nanotubes

Primary metallic or small-gap semiconducting nanotubes are tubes with band gaps that arise solely from breaking the bond symmetry due to curvature. We derive an analytic expression for these gaps by considering how a general symmetry breaking opens a gap in nanotubes with a well-defined chiral wrapping vector. This approach provides a straightforward way to include all types of symmetry-breaking effects, resulting in a simple unified gap equation as a function of chirality and deformations.
Large-alphabet quantum key distribution using spatially encoded light

Most quantum key distribution protocols using a two-dimensional basis, such as HV polarization as first proposed by Bennett and Brassard in 1984, are limited to a key generation density of 1 bit per photon. We increase this key density by encoding information in the transverse spatial displacement of the used photons. Employing this higher-dimensional Hilbert space together with modern single-photon-detecting cameras, we demonstrate a proof-of-principle large-alphabet quantum key distribution experiment with 1024 symbols and a shared information between sender and receiver of 7 bit per photon.
Immunopathologic Role of Eosinophils in Eosinophilic Chronic Rhinosinusitis

Chronic rhinosinusitis (CRS) is a diverse chronic inflammatory disease of the sinonasal mucosa. CRS manifests itself in a variety of clinical and immunologic patterns. The histological hallmark of eosinophilic CRS (ECRS) is eosinophil infiltration. ECRS is associated with severe disease severity, increased comorbidity, and a higher recurrence rate, as well as thick mucus production. Eosinophils play an important role in these ECRS clinical characteristics. Eosinophils are multipotential effector cells that contribute to host defense against nonphagocytable pathogens, as well as allergic and nonallergic inflammatory diseases. Eosinophils interact with Staphylococcus aureus, Staphylococcal enterotoxin B, and fungi, all of which were found in the tissue of CRS patients. These interactions activate Th2 immune responses in the sinonasal mucosa and exacerbate local inflammation. Activated eosinophils were discovered not only in the tissue but also in the sinonasal cavity secretion. Eosinophil extracellular traps (EETs) are extracellular microbes trapping and killing structures found in the secretions of CRS patients with intact granule protein and filamentous chromatic structures. At the same time, EET has a negative effect by causing an epithelial barrier defect. Eosinophils also influence the local tissue microenvironment by exchanging signals with other immune cells and structural cells. As a result, eosinophils are multifaceted leukocytes that contribute to various physiologic and pathologic processes of the upper respiratory mucosal immune system. The goal of this review is to summarize recent research on the immunopathologic properties and immunologic role of eosinophils in CRS.
China at large, Chinas for comparative conversation: a commentary on “Urbanizing dynamics of global China”

ABSTRACT This commentary brings diverse and dispersed urban geography analyses of global China into conversation. I show that findings from the pre-COVID-19 research presented in the four articles that comprise the special issue on Urbanizing Dynamics of Global China beg comparative questions of each other, both retrospective and future-facing. My hope is that the collection of articles will thus provide grounds for new comparative, and perhaps collaborative, research across urban Chinas that have previously been examined separately.