Miracle-dz/UniFAR-FTUs huggingface dataset:
O -GlcNAcase USES SUBSTRATE-ASSISTED CATALYSIS: KINETIC ANALYSIS AND DEVELOPMENT OF HIGHLY SELECTIVE MECHANISM-INSPIRED INHIBITORS.

The post-translational modification of serine and threonine residues of nucleocytoplasmic proteins with 2-acetamido-2-deoxy- D glucopyranose (GlcNAc) is a reversible process implicated in multiple cellular processes. The enzyme O -GlcNAcase catalyzes the cleavage of (cid:69) - O -linked GlcNAc ( O -GlcNAc) from modified proteins and is a member of the family 84 glycoside hydrolases. The family hexosaminidases bear no apparent sequence similarity yet are functionally related to O GlcNAcase since both enzymes cleave terminal GlcNAc residues from glycoconjugates. Lysosomal (cid:69) -hexosaminidase is known to use substrate-assisted catalysis involving the 2-acetamido group of the substrate, however, the catalytic mechanism of human O -GlcNAcase is unknown. Using a series of 4-methylumbelliferyl 2-deoxy-2- N -fluoroacetyl- D -glucopyranoside substrates, Taft-like linear free energy analyses of these enzymes indicates that O -GlcNAcase uses a catalytic mechanism involving anchimeric assistance. proposal, (cid:39) 2 (cid:397) thiazoline; 2 In our hands, both O -GlcNAcase and (cid:69) -hexosaminidase incubated with STZ showed no significant time-dependent loss of enzymatic activity when compared to a control containing no STZ (see supporting material). Thus STZ does not appear to act as an irreversible inhibitor of O -GlcNAcase nor (cid:69) hexosaminidase.
A SURVEY OF POWER-SAVING TECHNIQUES IN HPC

-- Energy aware data centers are new demand of the high performance computing (HPC) industry. In recent years, increasing research efforts have also been devoted to the design of practical power saving techniques in HPC which is a integral part of content delivery networks (CDN)s. This paper gives survey of latest researches on power optimization and estimation. We firstly highlight the necessities of saving power in HPC, followed by the identification of major power-saving strategies that have been widely exploited in the literature. Furthermore, We present high-level overview of the basic mechanisms to handle the power characteristics of HPC system. Then we review the power optimization research at various
SHIV Virus-Like Particles (VLPs) Vaccination Induces Partial Protection from SHIV Challenge in a Rhesus Macaque Model

Simian/Human immunodeficiency virus (SHIV) virus-like particles (VLPs) composed of SIV Gag, HIVsf162 gp120/ gp41 envelope, and human CD40L are whole pseudovirion vaccines capable of eliciting both humoral and cellular immunity. We immunized four rhesus macaques by intranasal prime and four sub-cheek boosts with VLPs adjuvanted with conjugatable adjuvant lipid vesicles containing monophosphoryl lipid A (MPLA), and compared their immune parameters to those in five unimmunized control macaques. Increased plasma antibody titers to SIV Gag were observed in all four immunized macaques and increased sf162 gp140 titers were observed in three of the four with one macaque (10-195) maintaining sustained anti-Env antibody levels. Compared to controls, a significant increase in memory B cells and CD4+ central memory T cells was detected in the immunized group. Among these, elevated Gag-specific CD107a membrane localization in the CD8+ central memory T cells was detected in one macaque (10-195). All nine macaques were subsequently challenged intrarectally with SHIVsf162.P3. After challenge, eight of the nine macaques became infected with SHIV, while the macaque 10-195 was protected. Another immunized macaque (10-189) that got infected but consequently generated high Gag-specific IFN- γ and CD107a CD8+ T cells; and Env-specific IL-2 and CD107a CD8+ T cells controlled virus and had undetectable levels of plasma SIV copy number by the termination of the study. Our VLPs vaccine strategy represents a promising immunogenic conformationally intact HIV vaccine that may lead to possible prevention and control of HIV infection.
WATER MELON - THE MUST MELON

Diuretic. melon is a beautiful, juicy, tasty fruit of the Cucurbitaceae family. This family contains all edible gourds, such as cucumbers, watermelons, Musk melons, pumpkins. Water melon is cultivated in all tropical and subtropical areas of the world for its nutritional and medicinal It is a flowering plant originally from South Africa. Watermelon is grown in tropical and subtropical areas worldwide for its large edible fruit which is a special kind of berry with a hard rind and no internal division, botanically called a pepo. [2] The sweet, juicy flesh is usually deep red to pink, with many black seeds, although seedless varieties have been cultivated. The fruit can be eaten raw or pickled and the rind is edible after cooking. Watermelon fruit is composed of flesh (68%), seeds (2%) and rind approximately 30% of the total mass of the fruit. The sweet interior flesh of watermelon fruit is usually deep red or pink and in sometimes orange, yellow or may be green if not ripe. Basic macronutrients of watermelon fruit include carbohydrates, protein, dietary fiber and
Correlates of unsafe injecting among injecting drug users in St Petersburg, Russia

Aims— To assess among injecting drug users (IDUs) in St Petersburg, Russia, the urban environmental, social norms, and individual correlates of unsafe injecting. Methods— Between December 2004 and January 2007 IDUs (N=446) were interviewed in St. Petersburg, Russia. Results— Prevalence of HCV was 96% and HIV 44%; 17% reported receptive syringe sharing after an HIV infected IDU (RSS); 49% distributive syringe sharing (DSS); 76% sharing cookers, 73% sharing filters and 71% syringe mediated drug sharing (SMS) when not all syringes were new. Urban environmental characteristics correlated with sharing cookers and SMS; and social norms correlated with RSS, DSS and sharing cookers. Individual correlates included cleaning used syringes (all five dependent variables) and self-report of HIV infection (RSS and DSS). Conclusion— HIV status disclosure is an unreliable but frequently used HIV prevention method among IDUs in St. Petersburg, who reported alarmingly high levels of injecting equipment sharing. Voluntary counseling and testing should be widely available for this population. Ethnography is needed to assess the effectiveness of the syringe cleaning process. Prevention interventions need to be ongoing among IDUs in St. Petersburg, and should incorporate urban environmental factors and social norms, which may involve peer education and social network interventions.
Optimal Energy Management in Nanogrids

—Home energy management is not efficient for a number of reasons. In this paper, we discuss a home energy management scheme which uses a nanogrid that introduces peak load shifting for energy control using the location patterns of the user. Sensors in the home can monitor the locations of residents and adjust the power consumption of the home in real time. This allows the system to estimate the behaviors of occupants in various situations to reduce the amount of power used. Major ideas and experimental systems are expected to be applied not only to green buildings but also to a large number of existing buildings to reduce the level of power consumption without sacrificing human comfort or convenience.
Enhancement of Usability of Information Security Systems

—An information security system can be divided into the administrator mode and the user mode, in terms of its interface. This research can provide a way to achieve effective results in terms of compliance with security policies through division. In this paper, we propose a human-centric security system which is based on user-centered security (User eXperience) interface. In particular, this study divides the user layer by profiling using the UX methodology's personalization method. Based on this, we apply the information security system on a scenario-by-scene basis, and prepare the factors that could cause difficulties in advance. The information security system was able to confirm the increase of the management level in terms of security policy compliance at the user side, resulting in insight from various HCI (Human Computer Interaction)s standpoints. This can lead to meaningful results that future users can reference in information security systems that they can directly control.
Characteristics of silicon-based Sagnac optical switches using magneto-optical micro-ring array

ABSTRACT The miniaturization and integration of optical switches are necessary for photonic switching networks and the utilization of magneto optical effects is a promising candidate. We propose a Sagnac optical switch chip based on the principle of nonreciprocal phase shift (NPS) of the magneto-optical (MO) micro-ring (MOMR) array, composed of SiO2/Si/Ce:YIG/SGGG. The MO switching function is realized by controlling the drive current in the snake-like metal microstrip circuit layered on the MOMRs. The transmission characteristics of the Sagnac MO switch chip dependent on magnetization intensity, waveguide coupling coefficient and waveguide loss are simulated. By optimizing the coupling coefficients, we design an MO switch using two serial MOMRs with a circumference of 38.37 μm, and the 3dB bandwidth and the extinction ratio are respectively up to 1.6 nm and 50dB for the waveguide loss coefficient of . And the switching magnetization can be further reduced by increasing the number of parallel MOMRs. The frequency response of the MO Sagnac switch is analyzed as well.
ENHANCING INTERPERSONAL RELATIONSHIP AND MOTIVATION THROUGH CREATIVITY TRAINING: AN INTERVENTIONAL STUDY

: The present study examined the effect of creativity training on interpersonal relationship and motivation. For this, 90 young adults from Periyar University, Salem (male = 45 and female = 45) were selected for this study. In this interventional study the participants were equally divided into 3 groups (Female group, male group and heterogeneous group). Fundamental interpersonal relationship orientation - behavior scale (FIRO-B) developed by William Schutz (1950) and situational motivation scale (SIMS) developed by E. L. Deci and R. M. Ryan (1991) were used to assess their motivation and interpersonal relationship before and after the creativity intervention and also a sustained effectiveness assessment was also done. Creativity intervention involved a set of creative exercises for a period of 14 days. The results revealed that there was a positive change in interpersonal relationship and motivation among the participants due to creativity intervention programme.
In vitro studies of iron absorption and activity of glutathione peroxidase in intestinal mucosa of the chicken

We examined the absorption of iron, the activity of selenoprotein glutathione peroxidase (GSH·Px) and cellular compartmentalization of metal in the chicken duodenum and ileum. The method of accumulating mucosa preparation (AMP) was used. It was shown that the intestinal iron accumulation is dose-dependent process, which has two components: transcellular and paracellular. The realization of these pathways is region-specific and depends on exposed iron levels. Slightly elevated iron status of intestinal mucosa does not influence activity of GSH·Px. At the same time the results indicate that the activity of glutathione peroxidase can be altered by iron overload. Immunohistochemistry revealed that stainable iron could be co-localized to the endolysosomal compartment. How the activity of enzyme can be affected by oxidative stress and competitive interactions of iron with selenium are discussed.
Magnonic crystal theory of the spin-wave frequency gap in low-doped manganites

A theory of three-dimensional (3D) magnonic crystal (conceived as the magnetic counterpart of the photonic crystal) is developed and applied to explain the existence of the spin-wave frequency gap, recently revealed by neutron scattering experiments, in low-doped La1−xCaxMnO3 manganites. A confrontation of the theory with experimental results proves that certain manganites can be regarded as 3D magnonic crystals existing in the nanoscale in nature.
Testing procedure for the models

Until recently, ‘the complex-the better’ paradigm has been the only viable solution, leading to complex and very deep oracles that can operate on a High-Performance Computing (HPC) platform only. For personal devices, then, two options are available: to accept an inevitable performance loss (in terms of speed or accuracy) or to use a cloud computing infrastructure with an online API. The situation is a bit different when active-sensor designs are exploited: in that case, the identity of an individual is evaluated using not only the 2D image grabbed by a webcam but also analyzing a 3D map of the face. Such a system is more robust but way more expensive, and its Abstract Face recognition functions are today exploited in many applications, from extended security systems to inclusion devices; deep neural network methods are reaching in this field stunning performances. The main limitation of the deep learning approach is an inconvenient relation between the accuracy of the results and the needed computing power. When a personal device is employed, in particular, many algorithms require a cloud computing approach to achieve the expected performances; other algorithms adopt models that are simple by design. A third viable option consists of model (oracle) distillation. This is the most intriguing among the compression techniques since it permits to devise the minimal structure that will enforce the same I/O relation as the original model. In this contribution, a distillation technique is applied to a complex model, enabling the introduction of fast state-of-the-art recognition capabilities on a low-end hardware face recognition sensor module. Two distilled models are presented in this contribution: the former can be directly used in place of the original oracle, while the latter better incarnates the end-to-end approach, removing the need for a separate alignment procedure. The presented biometric systems are examined on the two problems of face verification and face recognition in an open set by using well-agreed training/testing methodologies and datasets
Human Regulatory T Cells Contact-Dependent Immune Suppression by Kinetics and Activation Requirements of

Naturally occurring regulatory T cells (Tregs) maintain self tolerance by dominant suppression of potentially self-reactive T cells in peripheral tissues. However, the activation requirements, the temporal aspects of the suppressive activity, and mode of action of human Tregs are subjects of controversy. In this study, we show that Tregs display signiﬁcant variability in the suppressive activity ex vivo as 54% of healthy blood donors examined had fully suppressive Tregs spontaneously, whereas in the remaining donors, anti-CD3/CD2/CD28 stimulation was required for Treg suppressive activity. Furthermore, anti-CD3/CD2/CD28 stimulation for 6 h and subsequent ﬁxation in paraformaldehyde rendered the Tregs fully suppressive in all donors. The ﬁxation-resistant suppressive activity of Tregs operated in a contact-dependent manner that was not dependent on APCs, but could be fully obliterated by trypsin treatment, indicating that a cell surface protein is directly involved. By add-back of active, ﬁxed Tregs at different time points after activation of responding T cells, the responder cells were susceptible to Treg-mediated immune suppression up to 24 h after stimulation. This deﬁnes a time window in which effector T cells are susceptible to Treg-mediated immune suppression. Lastly, we examined the effect of a set of signaling inhibitors that perturb effector T cell activation and found that none of the examined inhibitors affected Treg activation, indicating pathway redundancy or that Treg activation proceeds by signaling mechanisms distinct from those of effector T cells. The Journal of Immunology , 2012, 188: 000–000.
TESTING A SYSTEM FOR PREDICTING MICROSLEEP

An instrument to objectively measure driver’s fatigue and to monitor approaching micro-sleep was designed, manufactured and tested. The instrument is based on a simple infrared sensor, which consists of an emitter and detector and is based on the different reflectivity of the eye and the skin of the eyelid. The instrument records eyelid activity as the number of blinks. The device has been put into practice in the form of lensless glasses and tested in an automobile simulator at the Faculty of Transport, Czech Technical University in Prague. The results show that the system was reasonably efficient at detecting fatigue, and therefore potentially micro-sleep. However, currently it is not possible to measure the effectiveness of the system and evaluate the results in real-time.
Demographic Factors and Brand Experience Affecting Sport Brand Advocacy of Consumers in Khon Kaen Province

: The purpose of this research was to study the demographic and brand experience factors that affected the brand advocacy in sporting goods businesses. The sample groups were the consumers who have used these services before and currently still used sport. The number of the consumers was 400 persons. The research instrument was a questionnaire. The data were analyzed by using descriptive statistics such as frequency, mean, and standard deviation, t-test, f-test, one way ANOVA and Pearson’s Product Moment Correlation Coefficient at 0 . 05 level of statistical significance . The result of the research indicated that demographic characteristics and brand experience factors had different effects on the consumer sports brand advocacy in Khon Kaen Province significantly at . 05 levels.
Observations at THz frequencies with CONDOR

The CO N Deuterium Observations Receiver, CONDOR, is one of the very few existing THz heterodyne receivers in the world. It covers a frequency range between 1.25 and 1.53 THz (240μm 196μm). CONDOR was built with a focus on observing star forming regions, using high-J CO lines H2D + and N In November 2005 we tested CONDOR on the APEX telescope, and successfully observed CO 13-12 in several regions in Orion. In FIR4 we find a surprisingly narrow CO 13-12 line width (5.4 km/s), from which we conclude that the hot gas is probably radiatively heated rather than shock excited. The observations of NGC2024 reviled additional hot gas. In order to model the CO lines between J= 3-2 and J=13-12 consistently a model with molecular gas in 4 different layers is required. High spectral resolution observations in the THz regime allow us not only to probe gas otherwise difficult to observe, but also to obtain information about the structure and kinematics of the source.
Adsorption of Zinc on Cassava Peels Activated Carbon and Kaolin Clay: Kinetics, Thermodynamics and Optimization Studies

Zinc in industrial, agricultural and domestic effluents gets into the human system and becomes toxic upon accumulation. The kinetics, thermodynamics and optimization of the process parameters for the adsorptions of zinc from zinc chloride (ZnCl2) simulated aqueous effluent using cassava peels activated carbon and kaolin clay were investigated. Proximate and oxide analyses carried out on the raw peels and the clay showed that the peels had 45% fixed carbon and the clay had more than 2% oxides of calcium, magnesium and iron in addition to alumina and silica. Whereas activated carbon was produced from the peels by carbonization at 700°C for 2hours in a muffle furnace, and subsequent treatment with phosphoric acid at 800°C for 2hours, the clay was not modified. The adsorption data generated at different levels of contact time were modeled and the pseudo-second-order kinetics model was adequate for the kinetics of the system at room temperature with regression coefficient (R2) of 0.998. The adsorption data also fitted into Langmuir, Freundlich and Temkin isotherms with a monolayer adsorption capacity of 4.8mg/g and 3.1mg/g for the activated carbon and clay respectively. The thermodynamic showed that the adsorption processes were endothermic and the magnitude of the standard enthalpy change showed that the adsorptions on the clay were more of physisorption while the adsorptions on the activated carbon were more of chemisorptions. Equally, the negative standard Gibb's free energy change showed that the processes were spontaneous. Optimization of the process parameters was carried out using the Box-Behnken design of Response Surface Methodology (RSM) and it was analyzed using Design Expert. Linear model was selected with R-squared, Adjusted R-squared and predicted R-squared values of 0.90, 0.89 and 0.88 respectively. The Analysis of Variance (ANOVA) of the model parameters showed that the effects of the five numeric factors, which are time, temperature, pH dosage and initial concentration, were statistically significant with p-values less than 0.01. It also showed that the effect of the one categorical factor, which is the type of adsorbent (clay or activated carbon), was statistically significant with the p-value less than 0.01. The numerical optimum solutions of the process parameters were obtained with theoretical percentage removal of 88% and 81% of zinc on cassava peels activated carbon and kaolin clay respectively.
Non-spherical supernova remnants. I: Calculations of the interaction of two remnants

On presente des calculs hydrodynamiques numeriques a deux dimensions concernant l'interaction des restes de deux supernovae qui explosent dans un milieu interstellaire de faible densite (1 particule/cm 3 ). On envisage quatre cas: 1) les supernovae explosent au meme endroit mais a des moments differents; 2) la seconde supernova explose a l'exterieur de l'enveloppe en expansion de la premiere; 3) la seconde explosion a lieu a l'exterieur de l'enveloppe en expansion de la premiere mais a une plus grande distance qu'en (2); 4) la seconde explosion se produit dans l'enveloppe de la premiere pendant la phase adiabatique
Anesthetic Considerations in Relation to a Child with Bardet-Biedl Syndrome: A Case Report

Bardet-Biedl syndrome is a rare autosomal-recessive disease characterized by central obesity, renal dysfunction, retinal dystrophy, dysmorphic extremities, cognitive impairment, hypogonadism, and endocrine and cardiac abnormalities. We present a case report of general anesthesia in a 7-year-old patient with Bardet-Biedl syndrome and morbid obesity (Body-Mass Index: 55.5kg/m 2 ). Because this syndrome is a multiple organ disorder that affects perioperative care, detailed preoperative examinations such as an echocardiographic examination of kidneys and heart should be performed to assess the current state of patients. In addition, anesthesiologists must be aware of the possibility of difficult airway management, morbid obesity, cardiac disorders and renal impairment.
The dynamic relationship between investments in brand equity and firm profitability: Evidence using trademark registrations1

Most marketing practitioners and scholars agree that marketing assets such as brand equity signiﬁcantly contribute to a ﬁrm’s ﬁnancial performance. In this paper, we model brand equity as an unobservable stock that results from up to thirty years of past brand-related investment ﬂows. Using ﬁrm-speciﬁc trademarks as investment proxies, our results show a signiﬁcant long-run impact on ﬁnancial performance. The dynamic proﬁle of brand-related investments has an inverted-U shape that reaches its peak after eleven years. On average, it takes four years before brand related investments show a positive return, and investments older than nineteen years show no signiﬁcant impact. For the median trademarking ﬁrm, brand equity contributes 265,000 Euro to annual proﬁts.