Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Grain Boundaries on the Elastic, Acoustical and Thermo-Physical Properties of Metal-Ceramics Composites

The purpose of this work was searching of the formation of grain boundaries in metal-ceramics composites at various metal concentrations and sintering temperatures, influence of these boundaries on elastic moduli, coefficient absorption ultrasonic waves (USW) and thermo-conductivity to find the coupling of these properties and to estimate the optimal value of the metal concentration for achieve high quality of ready composites “corundum-stainless steel”. These boundaries are formed in the sintering process. In this work, cermets sintered in a high vacuum at different temperatures are investigated. Сermets (metal-ceramic composites) are modern construction materials used in different branches of industry. Their toughness and heat resistance are determined by their elastic and thermo-physical properties. In addition, these properties are significantly dependent on the grain boundaries in the material. The elastic moduli and absorption coefficient were measured by the ultrasonic method at room temperature; measurement of the thermal conductivity coefficient was carried out at temperature 200°C. In addition the samples structure was investigated by optical and scanning electron microscopy (SEM), cermets composition was determined by energydispersive X-ray spectroscopy method (EDS). We found two extremes for the concentration dependence of the elastic moduli (E and G) on the stainless steel concentrations, the nature of which is unknown. Similar dependence is observed also for the thermal conductivity coefficient and coefficient absorption ultrasonic waves. A discussion of the results is based on the structure cermet model as multiphase micro heterogeneous media with isotropic physical properties is also presented. *Corresponding author: Abramovich A, St. Petersburg State University of Technology and Design, Higher School of Technology and Design, 198095 St. Petersburg, Russia, Tel: +78125402053; E-mail: a.abramovich@spbu.ru Received July 21, 2017; Accepted July 29, 2017; Published August 10, 2017 Citation: Abramovich A (2017) The Effect of Grain Boundaries on the Elastic, Acoustical and Thermo-Physical Properties of Metal-Ceramics Composites. J Material Sci Eng 6: 366. doi: 10.4172/2169-0022.1000366 Copyright: © 2017 Abramovich A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Genomic knowledge in the contextstic exome sequencing : changes over time , persistent subgroup differences , and associations with psychological sequencing outcomes

Methods: This longitudinal study used data from the North Carolina Clinical Genomic Evaluation by NextGen Exome Sequencing Study (NCGENES) of diagnostic exome sequencing to evaluate associations between factual genomic knowledge (measured with the University of North Carolina Genomic Knowledge Scale at three assessments from baseline to after return of results) and sequencing outcomes that reflected participants’ perceived understanding of the study and sequencing, regret for joining the study, and responses to learning sequencing results. It also investigated differences in genomic knowledge associated with subgroups differing in race/ethnicity, income, education, health literacy, English proficiency, and prior genetic testing.
Summary and critique of the thermodynamic properties of rock forming minerals

A structure, either an integral part of or an attachment to a tennis racket handle, including an upstanding backhand thumb-stop with a planar surface at a predetermined angle to the plane of the head of the racket, this planar surface being adapted to accept the pressure of the player's thumb when the racket is held in a backhand position and transmit this pressure to the handle in order to facilitate gripping the racket in the proper backhand position and to enable a player to more forcibly strike a tennis ball.
Text-mined fossil biodiversity dynamics using ma-1 chine learning: Extended methods 2

We simplified the information retrieval task by using the language detection method of 4 Shuyo (2014) to filter any non-English documents. We attempted to remove the reference 5 lists by doing a reverse, single match, case-insensitive regular expression search of the 6 phrases “references”, “literature list”, and “bibliography”, and disregarding the trailing 7 plain text. While titles of publications may contain valuable fossil occurrence information, 8 information retrieval using the reference list could lead to improper crediting of candidate 9 sources. 10
Challenges and Future Directions for Data Management in the Geosciences

AFFILIATIONS: sChuster, Mayernik, hou, anD stossMeister— National Center for Atmospheric Research, Boulder, Colorado; DoWns—Center for International Earth Science Information Network, Columbia University, Palisades, New York; kinkaDe— Woods Hole Oceanographic Institution, Woods Hole, Massachusetts; nguyen—Department of Chemistry, University of California, Irvine, Irvine, California; raMaMurthy—University Corporation for Atmospheric Research, Boulder, Colorado; Zhang—Department of Meteorology and Atmospheric Science, The Pennsylvania State University, University Park, Pennsylvania CORRESPONDING AUTHOR: Douglas C. Schuster, schuster@ucar.edu
lncrna KcnQ1OT1 enhances the chemoresistance of oxaliplatin in colon cancer by targeting the mir-34a/aTg4B pathway

Purpose: The chemoresistance of colon cancer to oxaliplatin (L-OHP) indicates poor prognosis. Long non-coding RNA (lncRNA) KCNQ1OT1 (KCNQ1 opposite strand/antisense transcript 1) has been shown to participate in the tumorigenesis of several types of cancers. However, little is known about the role of KCNQ1OT1 in the chemoresistance and prognosis of colon cancer. Materials and methods: Quantitative-PCR and Western blot were used to measure the expression profiles of KCNQ1OT1, miR-34a, and Atg4B in colon cancer tissues and cells. Cell viability assay and flow cytometry were used to examine their effects on cell proliferation and death. Cleavage of LC3 and GFP-LC3 plasmid transfection were used to detect autophagic activity. Double luciferase reporter assay was used to verify the interactions between miRNA and lncRNA or mRNA. Xenograft tumor model was used to verify the effects of KCNQ1OT1 in vivo. Results: In this study, it is shown that the expression level of KCNQ1OT1 was increased in tumor, which indicated poor prognosis in colon cancer patients. Using colon cancer cell lines HCT116 and SW480, it was demonstrated that knockdown of KCNQ1OT1 decreased the cell viability and increased the apoptosis rates upon L-OHP treatment. Further studies indicated that Atg4B upregulation was partially responsible for KCNQ1OT1-induced protective autophagy and chemoresistance. Moreover, miR-34a functioned as a bridge between KCNQ1OT1 and Atg4B, which could be sponged by KCNQ1OT1, while it could also bind to the 3 ′ -UTR of Atg4B and downregulate its expressions. Finally, we show that the KCNQ1OT1/miR-34a/Atg4B axis regulated the chemoresistance of colon cancer cells in vitro and in vivo. Conclusion: lncRNA KCNQ1OT1 promoted the chemoresistance of colon cancer by sponging miR-34a, thus upregulating the expressions of Atg4B and enhancing protective autophagy. KCNQ1OT1 might become a promising target for colon cancer therapeutics.
Effets du changement climatique sur les écosystèmes littoraux de la Mer Méditerranée Nord-occidentale: étude de la relation entre les conditions de température et la réponse biologique pendant les événements de mortalité massive

Memoria de tesis doctoral presentada por Carolina Crisci Karlen para optar al grado de Doctora por la Universite de la Mediterranee, realizada bajo la direccion del del Dr. Joaquim Garrabou Vancells del Institut de Ciencies del Mar (ICM-CSIC), del Dr. Badih Ghattas de la Universite de la Mediterranee y del Dr. Jean-Pierre Feral del Centre National de la Recherche Scientifique (CNRS) . -- 193 pages, 4 annexes
Comparison of Health Promoting Lifestyle in Guilan Medical and Non-Medical Sciences Students

Background: Since health-promoting lifestyle is an important determinant of health status, this study aimed to compare the healthpromoting lifestyle in medical and non-medical students of Guilan, Iran. Methods: This is a cross-sectional study with a descriptive-analytical approach that was performed on 1319 students of medical sciences and non-medical sciences in Guilan, 2014. The data collection tool was 52-item HPLP Π in six dimensions (health responsibility, physical activity, nutritional habits, stress management, spiritual growth, and interpersonal relationships). Data was analyzed using one-way ANOVA, T-test, and Kruskal–Wallis test. Results: The mean health-promoting lifestyle among students of Guilan University and Guilan University of Medical Sciences was (129.5± 7.17) and (128.1± 19), respectively. There was a significant difference between the two studied population in terms of health responsibility (p= 0.0001). Students of medical sciences had 3.2 times more favorable health promoting lifestyle (OR = 3.123, 95% CI = 1.57-6.3), married students 6.1 times (OR= 1.55, 95% CI = 1.052.32), students with mothers with under diploma degree 2.6 times (OR= 2.6 95% CI = 1.49-4.62), students with fathers with diploma 1.7 times (OR = 1.7, 95% CI = 1.2-2.56), and physical education and sports science students 5.8 times (OR = 8.5, 95% CI = 3.4220.95) had a more optimal health promoting lifestyle. Conclusion: In the present study, students' health-promoting lifestyles are in an unfavorable condition. Since the students in the future will be responsible for managing different sectors of the country and will play a role in changing the other health-promoting behavior of other strata of the society, it is important to consider their health-promoting lifestyles by providing facilities and eliminating the shortcomings.
The relations between sleep, time of activity, and time outdoors among adult women.

Physical activity and time spent outdoors may be important non-pharmacological approaches to improve sleep quality and duration (or sleep patterns) but there is little empiri-cal research evaluating the two simultaneously. The current study assesses the role of physical activity and time outdoors in predicting sleep health important moderators in assessing the relation between physical activity and sleep. More research is needed in larger populations using experimental designs.
Drug-target interaction prediction using Doubly Graph Regularized Matrix Completion

Motivation: The identification of interactions between drugs and target proteins is crucial in pharmaceutical sciences. The experimental validation of interactions in genomic drug discovery is laborious and expensive; hence, there is a need of efficient and accurate in silico techniques which can predict potential drug-target interactions to narrow down the search space for experimental verification. Results: In this work, we propose a new framework, namely, Doubly Graph Regularized Matrix Completion, which predicts the interactions between drugs and proteins from three inputs: known drug-target network, similarities over drugs and those over targets. The proposed method focuses on finding a low rank interaction matrix that is structured by the proximities of drugs and targets encoded by graphs. Extensive cross validation experiments on four benchmark datasets using standard evaluation metrics (AUPR and AUC)‘ show that the proposed algorithm improves the predictive performance and outperforms recent state-of-the-art computational methods. Availability
Dielectric Resonator-Based Passive Chipless Tag With Angle-of-Arrival Sensing

Passive chipless tags based on dielectric resonators (DRs) have been proposed for a novel millimeter-wave indoor self-localization system to mark fixed reference nodes. The tags employed in the system provide a unique spectral signature (resonance peaks) with much-increased radar cross section (RCS) by placing several identical DRs at the focal line of a spherical dielectric lens. Resonators of optimized geometry allow a modification of this original DR-lens tag by combining the lens with different size DRs which exhibit resonant frequencies separated by large frequency gaps. For easier manufacturing and testing, a demonstrator tag was designed for a “scaled” frequency range of 5–6 GHz with this configuration and is shown to produce spectral signatures of the monostatic RCS which are uniquely related to the angle of arrival (AoA) of the incident wave from a reader. Simulated signatures of a lens of 120-mm diameter with seven spherical DRs are presented and results are supported by experiment. Correlation processing of the signatures can give a resolution of few degrees in AoA while the bistatic RCS half-power beamwidth is on the order of 20°, and RCS levels of resonant peaks are produced between 0 and −6 dBm2.
Evolution and Religion

used in science. Religion is based on a belief that at some point (and this point can shift depending on how religious one is) events and experiences are caused by one or more mysterious and unknowable forces, spirits, absolute beings, universal minds, gods or divinities - the exact term used often depending upon the particular religion. For a long time, the relationship between these two concepts in Western culture, evolution and religion, were
A convenient protocol for establishing a human cell culture model of the outer retina. [version 1; peer review: 2 approved]

The retinal pigment epithelium (RPE) plays a key role in the pathogenesis of several blinding retinopathies. Alterations to RPE structure and function are reported in Age-related Macular Degeneration, Stargardt and Best disease as well as pattern dystrophies. However, the precise role of RPE cells in disease aetiology remains incompletely understood. Many studies into RPE pathobiology have utilised animal models, which only recapitulate limited disease features. Some studies are also difficult to carry out in animals as the ocular space remains largely inaccessible to powerful microscopes. In contrast, in-vitro models provide an attractive alternative to investigating pathogenic RPE changes associated with age and disease. In this article we describe the step-by-step approach required to establish an experimentally versatile in-vitro culture model of the outer retina incorporating the RPE monolayer and supportive Bruch’s membrane (BrM). We show that confluent monolayers of the spontaneously arisen human ARPE-19 cell-line cultured under optimal conditions reproduce key features of native RPE. These models can be used to study dynamic, intracellular and extracellular pathogenic changes using the latest developments in microscopy and imaging technology. We also discuss how RPE cells from human foetal and stem-cell derived sources can be incorporated alongside sophisticated BrM substitutes to replicate the aged/diseased outer retina in a dish. The work presented here will enable users to rapidly establish a realistic in-vitro model of the outer retina that is amenable to a high degree of experimental manipulation which will also serve as an attractive alternative to using animals. This in-vitro model therefore has the benefit of achieving the 3Rs objective of reducing and Open Peer Review
Comparison of the oxidative potential of primary (POA) and secondary (SOA) organic aerosols derived from α-pinene and gasoline engine exhaust precursors [version 1; peer review: 2 approved]

Background: Primary (POA) and secondary (SOA) organic aerosols, deriving from both anthropogenic and biogenic sources, represent a major fraction of ambient particulate matter (PM) and play an important role in the etiology of respiratory and cardiovascular diseases, largely through systemic inflammation and cellular oxidative stress. The relative contributions of these species to the inhalation burden, however, are rather poorly characterized. In this study, we measured the in vitro oxidative stress response of alveolar macrophages exposed to primary and secondary PM derived from both anthropogenic and biogenic sources. Methods: POA and SOA were generated within an oxidation flow reactor (OFR) fed by pure, aerosolized α-pinene or gasoline engine exhaust, as representative emissions of biogenic and anthropogenic sources, respectively. The OFR utilized an ultraviolet (UV) lamp to achieve an equivalent atmospheric aging process of several days. Results: Anthropogenic SOA produced the greatest oxidative response (1900 ± 255 μg-Zymosan/mg-PM), followed by biogenic (αpinene) SOA (1321 ± 542 μg-Zymosan/mg-PM), while anthropogenic POA produced the smallest response (51.4 ± 64.3 μg-Zymosan/mgPM). Conclusions: These findings emphasize the importance of monitoring and controlling anthropogenic emissions in the urban atmosphere, while also taking into consideration spatial and seasonal differences in SOA composition. Local concentrations of biogenic and anthropogenic species contributing to the oxidative potential of ambient PM may vary widely, depending on the given region and time of year, due to Open Peer Review
Is there a CDKN2A-centric network in pancreatic ductal adenocarcinoma?

: Pancreatic cancer has a high mortality rate and its incidence has risen rapidly in recent years. Meanwhile, the diagnosis and treatment of this cancer remain challenging. Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, but, currently, no suf ﬁ ciently effective modalities for its treatment exist. The early diagnosis rate of pancreatic cancer is low and most patients have reached an advanced stage at the time of diagnosis. PDAC evolves from precancerous lesions and is highly aggressive and metastatic. It is essential to understand how the disease progresses and metastasizes. CDKN2A mutations are very common in PDAC. Therefore, here, we have performed a literature review and discuss the role of CDKN2A and some related genes in the development of PDAC, as well as the basis of gene targeting with a correlation coef ﬁ cient of CDKN2A above 0.9 on the STRING website. It is noteworthy that the interaction of CDKN2A with each gene has been reported in the literature. The role of these genes and CDKN2A in PDAC may provide new directions that will advance the current knowledge base and treatment options since cancer progression is realized through interactions among cells. Our ﬁ ndings provide new insights into the treatment of PADC that can, to some extent, improve the diagnosis rate and quality of life of patients.
Transposition of the Great Arteries ( TGA )

Transposition of the great arteries or TGA is a potentially fatal congenital heart malformation where the pulmonary artery and the aorta are switched. The switch means that the aorta, which normally carries oxygenated blood, carries deoxygenated blood. There are two types of the malformation, d-TGA where no oxygen reaches the body and l-TGA where some oxygenated blood circulates. In the US, the Centers for Disease Control estimate that about 1,901 infants are born each year with TGA, or about one for every 2,000 births. Throughout history, physicians classified TGA as a condition that causes blue babies and hypothesized it was a fatal condition. With the development of corrective surgeries, studies on the causes of TGA, and improved prenatal diagnosis [2] have allowed for the survival rate for those with TGA to approach almost one hundred percent.
Bases técnicas para el control de mosquitos culícidos en los arrozales de la Comarca de La Janda, Cádiz (SW España)

Durante el ano 2002 se estudiaron las poblaciones de culicidos establecidas en los arrozales que, con una extension de 2.800 ha. , ocupan parte de la comarca de La Janda. El estudio intenta dar una respuesta tecnica a la demanda social de la poblacion humana asentada en torno a este ecosistema que padece los efectos de las plagas de culicidos. Se caracterizaron las poblaciones larvarias presentes en el arrozal, utilizando la tecnica de muestreo de dipping, identificandose un total de 8 especies de las cuales Anopheles atroparvus (Van Thiel), Ochlerotatus caspius Pallas, Ochlerotatus detritus Haliday y Culex pipiens Linnaeus, ya habian sido citadas en Cadiz; Culex modestus Ficalbi, Culex mimeticus Noe y Culex theileri Theobald son nuevas citas para esta provincia, mientras que Ochlerotatus dorsalis Meigen es nueva cita para Espana peninsular. Se obtuvieron datos sobre fenologia, distribucion y efectivos poblacionales larvarios y de imagos. Las poblaciones de imagos fueron muestreadas con trampas de luz CDC. Integrando ambas series de datos se diseno un plan de actuacion para la gestion de las poblaciones plagas de mosquitos estableciendo areas de seguridad en torno a los dos nucleos de poblacion mas importantes, prescribiendose tratamientos especificos con larvicidas de maxima eficacia y minimo impacto ambiental, temefos y Bacillus thuringiensis israelensis
Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review

: Cognitive frailty, defined as the coexistence of mild cognitive impairment symptoms and physical frailty phenotype in older persons, is increasingly considered the main geriatric condition predisposing to dementia. Recent studies have demonstrated that gut microbiota may be involved in frailty physiopathology by promoting chronic inflammation and anabolic resistance. The contribution of gut microbiota to the development of cognitive impairment and dementia is less defined, even though the concept of “gut–brain axis” has been well demonstrated for other neuropsychiatric disorders. The aim of this systematic review was to summarize the current state-of-the-art literature on the gut microbiota alterations associated with cognitive frailty, mild cognitive impairment and dementia and elucidate the effects of pre- or probiotic administration on cognitive symptom modulation in animal models of aging and human beings. We identified 47 papers with original data (31 from animal studies and 16 from human studies) suitable for inclusion according to our aims. We concluded that several observational and intervention studies performed in animal models of dementia (mainly Alzheimer’s disease) support the concept of a gut–brain regulation of cognitive symptoms. Modulation of vagal activity and bacterial synthesis of substances active on host neural metabolism, inflammation and amyloid deposition are the main mechanisms involved in this physiopathologic link. Conversely, there is a substantial lack of human data, both from observational and intervention studies, preventing to formulate any clinical recommendation on this topic. Gut microbiota modulation of cognitive function represents, however, a promising area of research for identifying novel preventive and treatment strategies against dementia.
Title : Neural correlates of gentle skin stroking in early infancy

word count: ~170 Manuscript word count: ~3.000 Number of tables: 2 Number of figures: 2 Number of supplementary material: 0 Highlights  The infant brain is sensitive to gentle skin stroking within the first weeks of age  The postcentral gyrus and posterior insular cortex are responsive to stroking