Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypertension Management in Primary Care A Cluster Randomized Trial of a Physician-focused Educational Intervention

Background: To improve hypertension control, this cluster randomized trial evaluated the effectiveness of physician manager education about hypertension management. Methods: After randomization at practice level, primary care physicians of the intervention arm, whose practices collaborated with a university department, participated in a three-session education on evidence-based hypertensiology and practice implementation strategies. The primary outcome was blood pressure (BP) control (ambulatory blood pressure [ABP] <130/80 mmHg) after 5 months. Secondary outcomes were changes in BP and practice routines regarding hypertension management. Following an intention-to-treat approach, data analyses included crude and adjusted generalized mixed models and sensitivity analyses. These took into account sex, age, ≥ hypertension-related disease and resistant hypertension (RH). Results: The analysis included 103 of 169 patients from 22 practices. Overall, BP decrease was –8.2 systolic and –4.1 mmHg diastolic. The intervention had no effect on BP control (odds ratio 0.84 [95% CI 0.29–2.43]) and BP changes (interventional effect: systolic –2.48 mmHg [95% CI –7.24 to 2.29], diastolic –0.25 mmHg [95% CI 3.31 to 2.82]). Sensitivity analysis indicated effect modification in patients with RH. Intervention practices requested educational input on difficult cases, and newly implemented 3 practice strategies (14.5±2.6 versus 11.4±2.2; P=0.005). Conclusions: After the short follow-up of 5 months, the intervention had no impact on BP control but improved the use of practice strategies. Weltermann
Compact microstrip low pass filter design using U‐shaped folded high‐impedance line

A microstrip low pass filter using a U‐shaped folded high impedance line is designed. Comparison with conventional filter has shown almost ripple free pass band and better stop band characteristics in the filter with folded line. Effective optimization of filter dimensions led to smoother and spurious free responses, which are desirable in the radio frequency and microwave systems. Size of overall filter is reduced by 7.5% and 9.02% for third order and fifth order filters, respectively. Both simulated and measured responses of fifth order filter are presented and found in agreement.
Spanking and Child Development during the First Five Years of Life

The authors used data from the Fragile Families and Child Wellbeing Study to examine whether spanking at ages 1 and 3 is adversely associated with child cognitive skills and behavior problems at ages 3 and 5. Results from cross-lagged path analyses revealed spanking at age 1 to be associated with a higher level of both spanking and externalizing behavior problems at age 3, and spanking at age 3 to be associated with a higher level of both internalizing and externalizing behavior problems at age 5. Additionally, the longer-term associations between spanking at age 1 and behavioral problems at age 5 appeared to predominantly operate through ongoing spanking at age 3. Results for cognitive skills, though less consistent, suggested no association between spanking at age 1 with poorer receptive vocabulary at age 3 or age 5. to the existing literature on spanking and child development by utilizing cross-lagged path models and data from the Fragile Families and Child Wellbeing Study (FFCW) to examine associations of spanking with child behavior problems and cognitive skills over the first five years of children’s lives. We particularly focus on spanking at age 1, which has received less attention than spanking at older ages. As described below, our empirical strategy allows us to better account for the reciprocal nature of the relation between spanking and child outcomes than has been possible in most prior work.
Integration of projection histograms and linear prediction for object tracking

Kertas kerja ini mengemukakan satu sistem visual untuk menjejak objek bergerak yang dapat beroperasi secara masa–nyata, efisien dan tahan lasak, dengan menggunakan turutan imej yang diperolehi daripada satu kamera statik. Algoritma menjejak yang dikemukakan menggabungkan teknik Unjuran Histogram dan kaedah Ramalan Linar untuk mencapai kelajuan menjejak yang lebih tinggi. Unjuran Histogram dilakukan untuk mendapatkan lokasi sebenar bagi objek yang dijejak, manakala kaedah Ramalan Linar disertakan dalam algoritma menjejak yang dikemukakan untuk meramal lokasi bagi objek bergerak dalam imej seterusnya, berdasarkan beberapa ukuran centroid sebelumnya. Hasil gabungan teknik Unjuran Histogram dan tertib kedua Ramalan Linar telah membolehkan algoritma yang dikemukakan untuk menjejak objek bergerak dengan tepat. Potensi and kecekapan bagi algoritma menjejak yang dikemukakan telah dibuktikan oleh keputusan menjejak yang baik pada beberapa turutan imej eksperimen. Kata kunci: menjejak pergerakan, Unjuran Histogram, Ramalan Linar, perbezaan bingkai In this paper, a real–time, efficient and robust visual tracking system for a single moving object using image sequences captured by a stationary camera is presented. The proposed tracking algorithm integrates the Projection Histograms technique with the Linear Prediction method in order to achieve a faster tracking speed. The Projection Histograms technique is applied to obtain the actual location of the tracked target, whereas the Linear Prediction method is incorporated in the proposed tracking algorithm to predict the location of the moving object in the next frame based on its several past centroid measurements. The Projection Histograms technique coupled with a second order Linear Prediction method has enabled the proposed algorithm to accurately track a single moving object. The potential applicability and efficiency of the proposed tracking algorithm has been validated by good tracking results on several experimental image sequences. Key words: Motion tracking, projection histograms, linear prediction, frame differencing
The Construction of an Engineered Bacterial Strain and Its Application in Accumulating Mercury from Wastewater

To remove organic and inorganic mercury from wastewater, an engineered bacterial strain, BL21-7, was constructed that contained the artificial operon P16S-g10-merT-merP-merB1-merB2-ppk-rpsT. For BL21-7, the minimum inhibitory concentrations of mercuric chloride, methylmercury chloride and phenylmercury chloride in Luria-Bertani (LB) medium were 100 µmol/L, 60 µmol/L and 80 µmol/L, respectively. After being cultured in three media (liquid LB containing 80 µmol/L mercuric chloride, 40 µmol/L methylmercury chloride or 60 µmol/L phenylmercury chloride) for 72 h, the engineered bacteria accumulated up to 70.5 ± 1.5 µmol/L, 33.5 ± 3.2 µmol/L and 45.3 ± 3.7 µmol/L of mercury, respectively. In the presence of 10 µmol/L Cd2+, 10 µmol/L Pb2+ or 10 µmol/L Cu2+, the accumulation of mercurial derivatives by BL21-7 was not affected. BL21-7 could accumulate mercury well in media with pH values ranging from 5 to 8 and it could work well at temperatures from 25 °C to 37 °C. After BL21-7 was added to wastewater and cultured for 24 h, approximately 43.7% of the Hg in the wastewater was removed.
Absence of Biallelic TCR (cid:1) Deletion Predicts Early Treatment Failure in Pediatric T-Cell Acute Lymphoblastic Leukemia

Purpose To identify children with T-cell acute lymphoblastic leukemia (T-ALL) at high risk of induction chemotherapy failure by using DNA copy number analysis of leukemic cells collected at diagnosis. recombination, as the most robust predictor of induction failure ( P (cid:1) . 001). This feature was also associated with markedly inferior event-free ( P (cid:2) . 002) and overall survival ( P (cid:1) . 001) rates: 25% versus 58% and 25% versus 72%, respectively. Using a rapid and inexpensive quantitative DNA-PCR assay, we validated ABD as a predictor of a poor response to induction chemotherapy in an independent series of patients. Conclusion Lymphoblasts from children with T-ALL should be evaluated at diagnosis for deletion within the TCR (cid:1) locus. Patients lacking biallelic deletion, which confers a high probability of induction failure with contemporary therapy, should be assigned to alternative therapy in the context of a prospective clinical trial. This article reports the results of comparative genomic hybridization (CGH) and quantitative
Decomposing ADHD-Related Effects in Response Speed and Variability

Objective— Slow and variable reaction times (RTs) on fast tasks are such a prominent feature of Attention Deficit Hyperactivity Disorder (ADHD) that any theory must account for them. However, this has proven difficult because the cognitive mechanisms responsible for this effect remain unexplained. Although speed and variability are typically correlated, it is unclear whether single or multiple mechanisms are responsible for group differences in each. RTs are a result of several semi-independent processes, including stimulus encoding, rate of information processing, speed-accuracy trade-offs, and motor response, which have not been previously well characterized. Method— A diffusion model was applied to RTs from a forced-choice RT paradigm in two large, independent case-control samples (N Cohort 1 = 214 and N Cohort 2 =172). The decomposition measured three validated parameters that account for the full RT distribution, and assessed reproducibility of ADHD effects. Results— In both samples, group differences in traditional RT variables were explained by slow information processing speed, and unrelated to speed-accuracy trade-offs or non-decisional processes (e.g. encoding, motor response). Conclusions— RT speed and variability in ADHD may be explained by a single information processing parameter, potentially simplifying explanations that assume different mechanisms are required to account for group differences in the mean and variability of RTs.
Pre-hemorrhage statin use and the risk of vasospasm following aneurysmal subarachnoid hemorrhage

Background and Purpose— Aneurysmal subarachnoid hemorrhage (SAH) is often followed by delayed ischemic deficits attributable to cerebral vasospasm. Recent studies suggest a positive impact of statin therapy on the incidence of vasospasm. This study was designed to assess whether a history of prior use of statin therapy was associated with a lower risk of vasospasm in patients with SAH. Methods— We performed a comprehensive retrospective review of patients with aneurysmal SAH between 1997 and 2004. Clinical demographics and imaging data for all patients were reviewed and a logistic regression analysis was performed to identify the predictors of cerebral vasospasm, defined as a combination of clinical signs with radiographic confirmation. Results— 308 patients were included. Mean age was higher in the group receiving statins (64 +/-12 versus 54+/- 12 years). Hunt and Hess scores and treatment modality were not significantly different between the groups. Vasospasm was observed in 31% of patients not taking a statin (n=282) versus 23% taking a statin (n=26), without achieving statistical significance. Discontinuation of the statin did not affect risk of vasospasm. Conclusions— Use of a statin prior to an aneurysmal SAH trended to reduce the incidence of subsequent vasospasm, without achieving statistical significance.
Proteome Dataset of Human Gingival Crevicular Fluid from Healthy Periodontium Sites by Multi-Dimensional Protein Separation and Mass Spectrometry

Background and Objective— Gingival crevicular fluid (GCF) has been of major interest for many decades as valuable body fluid that may serve as a source of biomarkers for both periodontal and systemic diseases. Because of its very small sample size, sub- μ l level, identification of its protein composition by classical biochemical methods has been limited. The advent of highly sensitive mass spectrometric technology has permitted large-scale identification of protein components of many biological samples. This technology has been employed to identify protein composition of GCF from inflamed and periodontal sites. In this report we present a proteome dataset of GCF from healthy periodontium sites. Methods— A combination of periopaper collection method with application of multidimensional protein separation and mass spectrometric (MS) technology led to a large-scale documentation of the proteome of GCF from healthy periodontium sites. Results— The approaches utilized have culminated in identification of 199 proteins in GCF of periodontally healthy sites. The current GCF proteome from healthy sites was compared and contrasted with those proteomes of GCF from inflamed and periodontal sites as well as serum. The cross-correlation of the GCF and plasma proteomes permitted dissociation of the 199 identified GCF proteins into, 105 proteins (57%) that can be identified in plasma and 94 proteins (43%) which are distinct and unique to GCF microenvironment. Such analysis also revealed distinctions in protein functional categories between serum proteins and those specific to GCF microenvironment. Conclusion— Firstly, the data presented herein provide the proteome of GCF from periodontally healthy sites through establishment of innovative analytical approaches for effective analysis of GCF from periopapers both at the level of complete elusion and removal of abundant albumin which restricts identification of low abundant proteins. Secondly, it adds significantly to the knowledge of GCF composition and highlights new groups of proteins specific to GCF microenvironment.
Multi‐leader–follower game theory for modelling interaction between virtual power plants and distribution company

Virtual power plant (VPP) is an entity that aggregates generation of distributed generation units. Thus, it is important to design a competitive framework which models the participation of the VPPs in the electricity market along with their trading with distribution company (DisCo). This study proposes a bilevel programming framework using the concept of multi-leader-follower game theory to determine the optimal contract prices of VPPs which compete against each other in the distribution network. The optimal prices are used for setting annual bilateral contracts with VPPs. The leader layer of the proposed bilevel problem includes VPPs, which try to maximise their profits, while the follower problem corresponds to the cost function of the DisCo, which aims to minimise the payments of supplying the forecasted demand. The DisCo optimisation problem is transferred by its Karush-Kuhn-Tucker optimality conditions, turning each VPP problem into an equivalent single-level optimisation problem. Some case studies are defined and implemented to assess the performance of the proposed scheduling model.
Clinical pharmacology of b 3-adrenoceptors

1 An atypical non b1/b2-adrenoceptor (AR) subtype (b3-AR) has been identified which is selectively stimulated by a group of ligands which mediate lipolytic and thermic responses in brown and white adipose tissue. 2 Molecular studies have shown that b3-AR in man are mainly expressed in visceral adipocytes, and to a lesser extent in gall-bladder and colon. In vitro studies with b3-AR agonists have shown activity at other sites including skeletal muscle and myocardium. 3 Regulation of b3-AR may differ from b1/b2-AR subtypes in that continuous agonist exposure does not result in receptor down-regulation. 4 A polymorphism of the human b3-AR gene (Trp64Arg) has been identified which is associated with obesity, insulin resistance and an earlier onset of non-insulin-dependent diabetes mellitus (NIDDM). Studies are required to establish whether expression of the mutant gene results in altered metabolic responses to b3-AR stimulation in man. 5 There is accumulating evidence to support a therapeutic role of b3-AR agonists in NIDDM because of anti-obesity and anti-diabetic activity, as a consequence of thermogenic effects as well as increased insulin sensitivity and glucose tolerance. 6 Selectivity studies with BRL35135 and isoprenaline in humans have demonstrated a b3-AR mediated component to thermogenesis which is dissociated from b1/b2-mediated effects on carbohydrate and fat metabolism. Similar studies have suggested a functional b3-AR mediating cardiac but not airway responses in humans. An evaluation of b3-AR agonists in irritable bowel syndrome may be warranted in view of colonic antimotility properties in vitro.
Results of a 29-State Survey of Tuberculosis in Nursing Homes and Correctional Facilities

All the authors are with the Surveillance and Epidemiologic Investigations Branch, Division of Tuberculosis Elimination, National Center for Prevention Services, Centers for Disease Control and Prevention. Ms. Hutton and Dr. Cauthen are Epidemiologists, and Dr. Bloch is a Medical Epidemiologist. Dixie E. Snider, Jr., MD, MPH, Kenneth E. Powell, MD, and Marion P. Meador, all formerly of the Division of Tuberculosis Elimination (DTBE), Centers for Disease Control and Prevention (CDC), contributed to the conceptual design of this study. William W. Stead, MD, of the Arkansas Department of Health, and Mary Hamilton, RN, of the Indiana State Board of Health, consulted regarding tuberculosis in institutions. Annette Ladan, formerly of DTBE, did computer programming. Al Sirocco of the Long Term Care Statistics Branch, National Center for Health Statistics, CDC, provided information regarding nursing home populations. Lawrence Greenfeld of the Bureau of Justice Statistics, Department of Justice, Gladys Lavelle and Carmellia Nickens of the Bureau of Prisons, Department of Justice, and Kristina Rose of the Justice Statistics Clearinghouse provided information regarding correctional populations. These results on tuberculosis in correctional facilities have been presented in part at annual meetings of the American Public Health Association, 1986 and 1989; the National Commission on Correctional Health Care, 1988 and 1989; and the National Tuberculosis Conference, 1989. Tearsheet requests to Technical Information Services, MS E06, National Center for Prevention Services, Centers for Disease Control and Prevention, Atlanta, GA 30333; tel. 404-639-1838. Prevention by 29 State health departments in 1984 and 1985 revealed that 7.7 percent of the victims older than age 64 were living in a nursing home at the time of diagnosis and 1.8 percent between the ages of 15 and 64 were living in a correctional institution at the time of diagnosis.
Iterative triangular inequality elimination algorithm for codebook search of vector quantization

This paper presents an iterative triangular inequality elimination (ITIE) algorithm for vector quantization (VQ) codebook search, which is then applied to the quantization of ISF coefficients in an AMR‐WB+ audio codec. Most of the codewords are ruled out as candidates using the ITIE rejection criterion, leading to considerable computational complexity reduction but with a well‐maintained coding quality. With a full search algorithm as the benchmark, this work gives a reduction in the total number of operations above 74%, a figure far beyond the 60% using the TIE algorithm with a dynamic and an intersection mechanism (DI‐TIE) and 65% using the equal‐average equal‐variance equal‐norm nearest neighbor search (EEENNS) algorithm. Furthermore, this work is expected to meet the energy‐saving requirement when implemented on an AMR‐WB+ audio codec of mobile devices. © 2018 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
What Can We Learn from the Study of Mexican-Origin Families in the U.S.?

Mexican-origin families are a large and rapidly increasing subgroup of the U.S. population, but they remain underrepresented in family scholarship. This paper introduces a special section of four papers on Mexican-origin families designed to contribute to the advancement of research on how cultural, family, and gender socialization processes unfold across key developmental periods and life transitions in this cultural context. Two longitudinal studies of Mexican-origin families provided the data for these four papers: (a) The Juntos Project , an eight-year longitudinal study of mothers, fathers, and adolescent sibling pairs in 246 Mexican-origin families; and (b) The Supporting MAMI Project , a study following 204 adolescent mothers and their mother figures from the third trimester of pregnancy through their young children's 5 th birthdays. In this introductory paper we highlight four themes, including (a) differential acculturation and reciprocal socialization, (b) interdependence in families, (c) the intersection of culture and gender, and (d) methodological issues, then offer suggestions for future research.
Functional Interplay Between the B-box 2 and the B30.2(SPRY) Domains of TRIM5 α

The retroviral restriction factors, TRIM5 α and TRIMCyp, consist of RING and B-box 2 domains separated by a coiled coil from carboxy-terminal domains. These carboxy-terminal domains (the B30.2(SPRY) domain in TRIM5 α and the cyclophilin A domain in TRIMCyp) recognize the retroviral capsid. Here we show that some B-box 2 changes in TRIM5 α , but not in TRIMCyp, resulted in decreased human immunodeficiency virus (HIV-1) capsid binding. The phenotypic effects of these B-box 2 changes on the restriction of retroviral infection depended on the potency of restriction and the affinity of the TRIM5 α interaction with the viral capsid, two properties specified by the B30.2 (SPRY) domain. Thus, some alterations in the TRIM5 α B-box 2 domain apparently affect the orientation or conformation of the B30.2(SPRY) domain, influencing capsid recognition. activity against human immunodeficiency virus-1 (HIV-1), N-tropic Moloney leukemia virus (N-MLV) and simian immunodeficiency virus (SIV mac ). The results show that, depending on the restriction potency of the parental proteins, a property determined by the B30.2(SPRY) domain, the same alterations of the B-box 2 domain can confer different phenotypes on retrovirus restriction. Moreover, the B-box 2 alterations used in this study dramatically affected the association of the TRIM5 α proteins with in vitro assembled HIV-1 CA-NC complexes, suggesting a functional interplay between the TRIM5 α B-box 2 and the B30.2(SPRY) domains.
Nicotine modulates neurogenesis in the central canal during EAE

Nicotine has been shown to attenuate experimental autoimmune encephalomyelitis (EAE) through inhibiting inflammation in microglial populations during the disease course. In this study, we investigated whether nicotine modified the regenerative process in EAE by examining nestin-expressing neural stem cells (NSCs) in the spinal cord, which is the primary area of demyelination and inflammation in EAE. Our results show that the endogenous neurogenic responses in the spinal cord after EAE are limited and delayed: while nestin expression is increased, the proliferation of ependymal cells is inhibited compared to healthy animals. Nicotine application significantly reduced nestin expression and partially allowed for the proliferation of ependymal cells. We found that reduction of ependymal cell proliferation correlated with inflammation in the same area, which was relieved by administration of nicotine. Further, increased numbers of oligodendrocytes (OLs) were observed after nicotine treatment. These findings give a new insight into the mechanism of how nicotine functions to attenuate EAE.