Miracle-dz/UniFAR-FTUs huggingface dataset:
Anesthesia for ambulatory surgery

Ambulatory anesthesia allows quick recovery from anesthesia, leading to an early discharge and rapid resumption of daily activities, which can be of great benefit to patients, healthcare providers, third-party payers, and hospitals. Recently, with the development of minimally invasive surgical techniques and short-acting anesthetics, the use of ambulatory surgery has grown rapidly. Additionally, as the indications for ambulatory surgery have widened, the surgical methods have become more complex and the number of comorbidities has increased. For successful and safe ambulatory anesthesia, the anesthesiologist must consider various factors relating to the patient. Among them, appropriate selection of patients and surgical and anesthetic methods, as well as postoperative management, should be considered simultaneously. Patient selection is a particularly important factor. Appropriate surgical and anesthetic techniques should be used to minimize postoperative complications, especially postoperative pain, nausea, and vomiting. Patients and their caregivers should be fully informed of specific care guidelines and appropriate responses to emergency situations on discharge from the hospital. During this process, close communication between patients and medical staff, as well as postoperative follow-up appointments, should be ensured. In summary, safe and convenient methods to ensure the patient's return to function and recovery are necessary.
Replacement

30 31 Objective: Microangiopathy and dysregulation of the immune system play important roles in the 32 pathogenesis of Systemic Sclerosis (SSc). Factors that trigger vascular injury in SSc have not been 33 elucidated so far. To evaluate whether sex or expression of specific antinuclear auto-antibodies might 34 associate with the degree of microangiopathy we performed a systematic review summarizing what is 35 known about these associations. 36 Method: Standardized search of PubMed, EMBASE, Web of Science and the Cochrane library were 37 performed to identify studies, that report on auto-antibodies in SSc patients and microangiopathy, and for 38 the second search, that report on sex and microangiopathy. 39 Result: Eleven studies were included that report on the relationship between SSc specific auto-antibodies 40 and microangiopathy, and six studies were included that report on the association between sex and 41 microangiopathy. Contradictory results were found on the association between auto-antibodies and 42 microangiopathy, and no association was found between sex and microangiopathy based on the current 43 literature. 44 Conclusion: Based on this review of the literature we can conclude that sex does not seem to influence 45 degree of microangiopathy in SSc, while results on association between SSc specific auto-antibodies and 46 degree of microangiopathy were inconclusive. 47 modalities: NVC, dermoscopy, confocal microscopy, image
Prediction of lncRNA–disease associations based on inductive matrix completion

Motivation Accumulating evidences indicate that long non-coding RNAs (lncRNAs) play pivotal roles in various biological processes. Mutations and dysregulations of lncRNAs are implicated in miscellaneous human diseases. Predicting lncRNA-disease associations is beneficial to disease diagnosis as well as treatment. Although many computational methods have been developed, precisely identifying lncRNA-disease associations, especially for novel lncRNAs, remains challenging. Results In this study, we propose a method (named SIMCLDA) for predicting potential lncRNA-disease associations based on inductive matrix completion. We compute Gaussian interaction profile kernel of lncRNAs from known lncRNA-disease interactions and functional similarity of diseases based on disease-gene and gene-gene onotology associations. Then, we extract primary feature vectors from Gaussian interaction profile kernel of lncRNAs and functional similarity of diseases by principal component analysis, respectively. For a new lncRNA, we calculate the interaction profile according to the interaction profiles of its neighbors. At last, we complete the association matrix based on the inductive matrix completion framework using the primary feature vectors from the constructed feature matrices. Computational results show that SIMCLDA can effectively predict lncRNA-disease associations with higher accuracy compared with previous methods. Furthermore, case studies show that SIMCLDA can effectively predict candidate lncRNAs for renal cancer, gastric cancer and prostate cancer. Availability and implementation https://github.com//bioinfomaticsCSU/SIMCLDA. Supplementary information Supplementary data are available at Bioinformatics online.
LINE-1 retrotransposons facilitate horizontal gene transfer into poxviruses

There is ample phylogenetic evidence that many critical virus functions, like immune evasion, evolved by the acquisition of genes from their hosts through horizontal gene transfer (HGT). However, the lack of an experimental system has prevented a mechanistic understanding of this process. We developed a model to elucidate the mechanisms of HGT into vaccinia virus, the prototypic poxvirus. All identified gene capture events showed signatures of long interspersed nuclear element-1 (LINE-1)-mediated retrotransposition, including spliced-out introns, polyadenylated tails, and target site duplications. In one case, the acquired gene integrated together with a polyadenylated host U2 small nuclear RNA. Integrations occurred across the genome, in some cases knocking out essential viral genes. These essential gene knockouts were rescued through a process of complementation by the parent virus followed by nonhomologous recombination during serial passaging to generate a single, replication-competent virus. This work links multiple evolutionary mechanisms into one adaptive cascade and identifies host retrotransposons as major drivers for virus evolution.
estimating cost savings of pharmacogenetic testing for depression in real-world clinical settings

and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). Neuropsychiatric Disease and Treatment 2018:14 225–230 Neuropsychiatric Disease and Treatment Dovepress
Flaxseed ( Linum usitatissimum ) Oil Extraction Using Different Solvents

Guilherme Sabadin Piva, Thiago André Weschenfelder, Elton Franceschi, Rogério Luis Cansian, Natalia Paroul, Clarice Steffens Department of Food Engineering, URI Erechim, Av. Sete de Setembro 1621, ErechimRS, 99700-000, Brazil. 2 Colloidal System Research Center (NUESC), Research and Technology Institute (ITP), Tiradentes University (UNIT) 49032-490, Aracaju, SE, Brazil. Received: April 24, 2017 Accepted: May 23, 2018 Summary
Fell‐Muir Lecture: Syndecans: from peripheral coreceptors to mainstream regulators of cell behaviour

In the 25 years, as the first of the syndecan family was cloned, interest in these transmembrane proteoglycans has steadily increased. While four distinct members are present in mammals, one is present in invertebrates, including C. elegans that is such a powerful genetic model. The syndecans, therefore, have a long evolutionary history, indicative of important roles. However, these roles have been elusive. The knockout in the worm has a developmental neuronal phenotype, while knockouts of the syndecans in the mouse are mild and mostly limited to post‐natal rather than developmental effects. Moreover, their association with high‐affinity receptors, such as integrins, growth factor receptors, frizzled and slit/robo, have led to the notion that syndecans are coreceptors, with minor roles. Given that their heparan sulphate chains can gather many different protein ligands, this gave credence to views that the importance of syndecans lay with their ability to concentrate ligands and that only the extracellular polysaccharide was of significance. Syndecans are increasingly identified with roles in the pathogenesis of many diseases, including tumour progression, vascular disease, arthritis and inflammation. This has provided impetus to understanding syndecan roles in more detail. It emerges that while the cytoplasmic domains of syndecans are small, they have clear interactive capabilities, most notably with the actin cytoskeleton. Moreover, through the binding and activation of signalling molecules, it is likely that syndecans are important receptors in their own right. Here, an overview of syndecan structure and function is provided, with some prospects for the future.
Modélisation physique tridimensionnelle des mouvements gravitaires de grande ampleur en milieu rocheux

La gravite est un des facteurs controlant l'evolution des chaines de montagnes. Ses effets les plus connus sont les glissements de terrain. Elle genere aussi des mouvements evoluant a plus grande echelle d'espace et de temps, dont les effets peuvent passer inapercus, confondus avec ceux de la tectonique ou masques par l'erosion. Ces mouvements sont connus sous le nom de DSGSD (Deep Seated Gravitational Slope Deformation). La comprehension de ce phenomene est importante du point de vue de la geologie structurale, de la geomorphologie ou de la prevention des risques naturels. Le manque d'observations en profondeur fait que les modalites de la rupture mises en jeu dans ces mouvements sont inconnues. Nous avons etudie les DSGSD par une approche de modelisation physique tridimensionnelle. Le premier objectif a donc ete de finaliser la mise au point d'un protocole experimental original. Cette methode est fondee sur l'utilisation de nouveaux materiaux analogues et d'un dispositif de chargement gravitaire permettant de realiser des modeles satisfaisant les criteres de similarite. Ce protocole presente l'avantage de pouvoir observer la deformation des modeles de maniere incrementale, ainsi que de permettre la realisation de coupes au sein des modeles. Notre etude a montre que la profondeur maximale de la surface de rupture est comparable a la hauteur de l'edifice affecte. Par ailleurs, au cours de l’evolution de la rupture, ces phenomenes participent au declenchement de mouvements gravitaires de plus petite taille. Il a egalement pu etre mis en evidence que la topographie a grande echelle est un facteur majeur controlant la geometrie et la repartition des mouvements gravitaires.
Multidetector row computed tomography arteriography in the preoperative assessment of patients with Klippel e Trénaunay syndrome

To the Editor: We read with interest the article by Bastarrika et al in the February 2007 issue of the Journal related to preoperative assessment of patients with KlippeleTrénaunay syndrome (KTS). On the basis of their findings, the authors conclude that multidector row computed tomography (MDCT) and three-dimensional magnetic resonance (3D-MR) venography are extremely helpful for the global evaluation of patients with KTS. We agree with Bastarrika et al’s conclusion of venography in the preoperative assessment of patients with KTS. However, the authors provide no information of MDCT and 3DMR arteriography with regard to the evaluation and limitation of the venography. MDCT and 3D-MR arteriography play an important role in the diagnosis of KTS and Parkes Weber syndrome (PWS). They are similar disorders with complex vascular malformations. Significant arteriovenous fistulas are the hallmark, distinguishing KTS from PWS. Arteriovenous shunting is characterized by early appearing draining veins. 3D-MR arteriography may detect arteriovenous shunting noninvasively and therefore distinguish PWS from KTS. Secondly, therewasnomentionof influenceof the lymphedema on the injection of contrast material via a subcutaneous superficial vein of the affected leg. Sometimes, it could lead to a failure of direct venography. We encountered an 18-year-old male with symptoms of exacerbation of severe pain in the left leg and nonhealing skin ulceration over the knee joint. The physical examination revealed prominent varicose veins in his left foot and calf and port-wine stains of the left leg, which was significantly hypertrophic compared to the right one. To evaluate potential therapeutic strategies, we performed a combined MDCT arteriography and venography. MDCT arteriography (Fig 1) revealed two evident low-flow arteriovenous malformations, which cannot be demonstrated in direct venography. There is no early appearing of the draining veins; according to this, the diagnosis of KTS was made and PWS was excluded in our patient. Even if MDCT and 3D-MR venography is useful for the evaluation of potential therapeutic strategies of patients with KTS, we believe that arteriography should be considered as the first step in the endovascular management of the disease. As for patients
PHYTOCHEMICAL INVESTIGATION AND ANTI-MICROBIAL ACTIVITY OF CLAUSENA (WILLD),

Background : Clausena anisata belongs to the family Rutaceae, a shrub widely used in West Africa for the treatment of bacterial and fungal infections of the skin including boils, ringworm and eczema. The study was designed to evaluate the antimicrobial activity and phytochemical screening of ethanol leaf extract of C . anisata (CLE) . Method : Antimicrobial activity of CLE was investigated using agar well diffusion and micro-dilution methods against four Gram-positive bacteria ( Bacillus substilis NCTC 10073 , Staphylococcus aureus ATCC 25923 , Enterococcus faecalis ATCC 29212, Bacillus thuringiensis ATCC 13838) and two Gram-negative bacteria ( Pseudomonas aeruginosa ATCC 4853, Proteus vulgaris ATCC 4175) and a clinical isolate of Candida albicans . Results : CLE was active against all test organisms with minimum inhibitory concentration (MIC), range of 0.5 to 7.0 mg/mL against Gram-positive bacteria, 2.5 to 1.0 mg/mL against Gram-negative bacteria and 5.5mg/mL against C. albicans. The MICs of the methanol fraction of CLE were 0.6 mg to 5.0/mL and 1.0 to 3.0 mg/mL for Gram-positive and Gram-negative bacteria respectively. Chloroform fraction had MIC of 3.0 to 7.5 mg/mL and 2.0 to 6.5 mg/mL for Gram-positive and Gram-negative bacteria, respectively and petroleum ether fraction had 4.5 to 8.0 mg/mL for Gram-positive and Gram-negative bacteria. The CLE exhibited static action against all test organisms within a range of 0.5 to 22.0 mg/mL. Phytochemical screening of C. anisata revealed the presence of tannins, flavonoids, steroids, saponins, glycosides and alkaloids. HPLC finger-printing of the CLE and its fractions were determined. Conclusion : These results may justify the medicinal uses of C. anisata for the treatment of microbial infections. its and petroleum ether fractions against some microorganisms and also perform preliminary phytochemical on the ethanol extract and its fractions of C. anisata Enterococcus faecalis were used as test organisms in the determination of antimicrobial activity of C. anisata extract and its fractions. Clinical isolates of Staphylococcus aureus, Enterococcus faecalis and Candida albicans obtained from the Bacteriology Unit of Komfo Anokye Teaching Hospital, Kumasi, Ghana and Pseudomonas aeruginosa and Proteus vulgaris were obtained from the Bacteriology Unit of Kumasi Centre for Collaborative Research (KCCR), Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. saponins, phenolics, flavonoids, cardiac glycosides and anthraquinones glycosides. HPLC finger-printing of the ethanol leaf extract and the various fractions were developed. The individual or the additive or synergistic effects of the phytochemical constituents present in the C. anisata leaf extract may be responsible for antibacterial and antifungal properties and may justify use of the plant for treatment of microbial infections.
Two Vocabulary Learning Tools Used by Iranian EFL Learners: Physical Flashcards versus a Mobile App

With the help of technology and the Internet, foreign language students can learn vocabulary more conveniently than ever before. Meanwhile, increasing attention is being paid to mobile-assisted language learning (MALL). In this regard, the current study compared the effectiveness of digital flashcards in the form of an app and conventional paper flashcards. This study was based on a quasi-experimental design, and participants were recruited via convenience sampling. A total of 34 participants took part in the study. There were two groups of students, the experimental group that learned through mobile devices and the control group that learned through paper flashcards. There was a significant improvement in L2 vocabulary learning with digital and non-digital flashcards, but the Anki app was more effective. Moreover, ten students took part in the qualitative portion of the research to explore the merits and disadvantages of either types of vocabulary learning tools presented in this study through semi-structured interviews. This study implemented a mixed-method design. Based on the findings of the present study, paper flashcards shouldn't be dismissed altogether by learners and teachers. This is because they reduce screen time and distractions as well as stimulate muscle memory while learning. In addition, students can control their repetition cycles, physically manipulate them as they wish, and take control over how much information they repeat.
Conceptual energy and water recovery system for self-sustained nano membrane toilet

With about billion The Nano Membrane Toilet is expected to provide a unique household-scale system that would produce electricity and recover water from human excrement and urine. This study was undertaken to evaluate the performance of the conceptual energy and water recovery system for the Nano Membrane Toilet designed for a household of ten people and to assess its self-sustainability. A process model of the entire system, including the thermochemical conversion island, a Stirling engine and a water recovery system was developed in Aspen Plus (cid:1) . The energy and water recovery system for the Nano Membrane Toilet was characterised with the speciﬁc net power output of 23.1 Wh/kg settledsolids and water recovery rate of 13.4 dm 3 /day in the nominal operating mode. Additionally, if no supernatant was processed, the speciﬁc net power output was increased to 69.2 Wh/kg settledsolids . Such household-scale system would deliver the net power output (1.9–5.8 W). This was found to be enough to charge mobile phones or power clock radios, or provide light for the household using low-voltage LED bulbs.
System identification using genetic programming

GP4SI [4] is a tool for system identification using Genetic Programming. It generates Simulink-models that aim at describing the input-output data of a system. The quality of these models is evaluated by a so-called fitness-function. In this study this fitness-function and the settings of GP4SI are respectively redesigned and optimized. This results in a better understanding of the working and possibilities of GP4SI, guidelines for the settings and a frequency-domain based fitness-function. Several 2nd, 4th-and higher order example plant-models are successfully identified.
F-actin prevents interaction between sperm DNA and the oocyte meiotic spindle in C. elegans

female meiosis in most animals, which raises the question of what prevents the sperm DNA from interacting with the meiotic spindle. In this study, we find that Caenorhabditis elegans sperm DNA stays in a fixed position at the opposite end of the embryo from the meiotic spindle while yolk granules are transported throughout the embryo by kinesin-1. In the absence of F-actin, the sperm DNA, centrioles, and organelles were transported as a unit with the yolk granules, resulting in sperm DNA within 2 µm of the meiotic spindle. F-actin imaging revealed a cytoplasmic meshwork that might restrict transport in a size-dependent manner. However, increasing yolk granule size did not slow their velocity, and the F-actin moved with the yolk granules. Instead, sperm contents connect to the cortical F-actin to prevent interaction with the meiotic spindle.
Cucurbita argyrosperma seed extracts attenuate 2 angiogenesis in a corneal chemical burn model 3

: Cornea severe inflammation produces opacity or even perforation, scarring, and angiogenesis, resulting in blindness. The cornea can be used to study the effect of new anti- angiogenic chemopreventive agents. We researched the anti-angiogenic effect of two extracts, 16 Methanol (Met) and Hexane (Hex), from the seed of Cucurbita argyrosperma , in the inflamed corneas. The corneas of Wistar rats were alkali-injured and treated intragastrically for seven successive days. Clinical manifestation as opacity score, corneal neovascularization (CNV) area, re-epithelialization percentage, and histological evaluation were performed. Inflammatory (COX-2, NF-κB, and IL-1β), 20 and angiogenic (VEGF-A, VEGFR1, VEGFR2) markers were assessed by immunohistochemistry. 21 Cox-2 , Il-1β , and Vegf-a mRNA levels were also determined. After treatments, we observed slim 22 corneal thickness with lower opacity scores and low cell infiltration compared to untreated rats. 23 Treatment also accelerated wound healing and decreased CNV area. The staining of inflammatory 24 and angiogenic factors was significantly decreased. These effects are related to a down-expression 25 of Cox-2 , Il-1β , and Vegf . These results suggest that intake of C. argyrosperma seed can be used to 26 attenuate the angiogenesis secondary to inflammation in corneal chemical damage. of monocytes and directed towards the damaged microenvironment. For these reasons, this evaluates both endothelial cells in the angiogenic environment: (1) VEGFR1 as a marker in the infiltration of monocytes and neovessels and (2) VEGFR2 as an active marker of angiogenesis. Our results show that the staining intensity and the expression of Vegf-a decreased along with the staining of VEGFR2 and VEGFR1 in endothelial cells of extract- treated corneas. Additionally, the decrease of Il-1β and Cox-2 expressions were also observed, suggesting that hexanic- and methanolic-extract components can attenuate these pro-angiogenic factors, likely through a lack of nuclear activation of NF-κB, which was also observed. causes loss due to CNV. Corneal not only NF-κB, IL-1β, and COX-2 expression, but also significantly increase VEGF and their receptors VEGFR1 and VEGFR2 in endothelial cells. This work demonstrates for the first time, that methanolic or hexanic extracts of C. argyrosperma seed (400 mg/kg/7d) improves the healing of corneal wound injured by a chemical agent and may contribute to the anti-inflammatory properties of the phytochemicals in its composition. In addition, a significant reduction of the CNV was related to the attenuation of proangiogenic factors. Significantly, our results indicate that C. argyrosperma Hex- extract is better than Met-extract to reduce the corneal re-epithelialization time, improving the healing process and thus preventing the entrance of microorganisms and inflammatory mediators into the deeper layers, probably through the inhibition of the NF-κB pathway at least seven days alkali-burn.