Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relationship between Serum Procalcitonin and Dialysis Adequacy in Hemodialysis Patients

Introduction: In hemodialysis (HD) patients procalcitonin (PCT) considered as an early predictor of acute infection. It represents a new and potential marker of inflammation and may correlate with dialysis adequacy. This makes procalcitonin a potential biomarker for obesity-related low-grade inflammation. Objective: The aim of the work was to assess procalcitonin level in obese prevalent hemodialysis patients and its relation to hemodialysis adequacy. Patients and Methods: A cross sectional study was conducted on 90 patients divided into 3 groups, 40 obese (BMI ≥ 30 Kg/m2) ESRD patients on regular hemodialysis ( group A ), 40 non obese (BMI < 25 Kg/m2) ESRD patients on regular hemodialysis ( group B ) attending at Dialysis Unit, El-Sahel Teaching Hospital and 10 healthy individuals with BMI < 25 Kg/m2 as a control group ( group C ). All patients were subjected to detailed history taking and general examination. All patients were laboratory investigated for CBC, serum urea, creatinine, CRP, urea reduction ratio (URR), equilibrated Kt/v. All controls were subjected to written informed consent, full history, examination and CRP level. Procalcitonin level was done by ELISA technique for all patients and controls. Results: In our study, we found that there was a higher level of procalcitonin (PCT) in obese hemodialysis patient than non-obese. We also found that there was no correlation between PCT and hemodialysis adequacy in our study population. Conclusion: It could be concluded that procalcitonin is a potential biomarker for obesity-related low-grade inflammation, but not related to hemodialysis adequacy.
Synthesis, Controlled Release, and Stability on Storage of Chitosan-Thyme Essential Oil Nanocapsules for Food Applications

The nanoencapsulation of thyme essential oil has been greatly important in food science, given its remarkable antioxidant and antimicrobial capacity. However, its analysis in storage has not been established in terms of physical stability, antioxidant capacity, and release studies. In this paper, chitosan-thyme oil nanocapsules were prepared by the ionic gelation method. These were characterized for differential calorimetry, release kinetic, and infrared spectroscopy. The chitosan-thyme oil nanocapsules were stored at 4 and 25 °C for 5 weeks, the changes in particle size, zeta potential, stability (diffuse reflectance), and antioxidant capacity were analyzed and associated with nanocapsules’ functionality. The results show that the storage time and temperature significantly modify the particle size (keeping the nano-size throughout the storage), the release of the bioactive was Fickian with t0.193 according to Korsmery & Peppas and best described by Higuchi model associated with changes in the zeta potential from 8 mV to −11 mV at 4 °C. The differential scanning calorimetry and infrared spectroscopy results confirm the good integration of the components. The antioxidant capacity revealed a direct relationship with residual oil concentration with a decrease in the ABTS test of 15% at 4 °C and 37% at 25 °C. The residual bioactive content was 77% at 4 °C and 62% at 25 °C, confirming nanoencapsulation effectiveness. The present investigation provides helpful information so that these systems can be applied in food conservation.
Research on the Capability in Absorbing Electric Vehicles in Beijing Grid

This paper analyzes the load characteristics of electric vehicle under different charging modes including disordered charging, peak shifting charging and continuous charging. Taking a typical distribution network in Beijing as the research object, the calculation of steady state operation is carried out under the three kinds of charging modes after the integration of electric vehicles at different scales. The voltage deviation and load rate are analyzed to reveal the impact of charging modes on the capability in absorbing electric vehicles in Beijing grid.
The Prevalence and Health Impacts of Frequent Work Discrimination and Harassment among Women Firefighters in the US Fire Service

Intro Both discrimination and harassment directly impact mental and physical health. Further, workplace discrimination degrades workplace culture and negatively impacts health behaviors, job-related outcomes, and family dynamics. Women represent a small proportion of the fire service and are often the targets of discrimination/harassment, yet little research documents the impact of such experiences. The purpose of this study was to evaluate the relationship between chronic work discrimination and/or harassment and women firefighters' (FFs) physical and mental health, substance abuse, and job efficacy, stress, and satisfaction. Methods Snowball sampling was used to solicit participation from women career FFs. Participants completed an online survey regarding physical and mental health, health behavior, job efficacy/stress/satisfaction, and family well-being. Logistic regression examined the impact of work discrimination-harassment severity on dichotomous variables. Results 1,773 had complete data on their experiences with work-related discrimination and harassment. Women reported experiencing verbal (37.5%) and written (12.9%) harassment, hazing (16.9%), sexual advances (37.4%), and assaults (5.1%) in the fire service. FFs in the highest tertile of work discrimination-harassment severity reported over 40% more poor health days in the last 30 days (OR=1.42; 95%CI=1.33-1.51; p<0.001). Women who experienced moderate and severe discrimination/harassment had negative mental health outcomes including higher prevalence of depressive symptoms, anxiety, and PTSD symptoms. Those who experienced high rates of discrimination and/or harassment also were more likely to report issues with alcohol consumption. Conclusion The impact of discrimination and harassment, related negative physical and mental outcomes, low levels of job satisfaction, and negative impact of these experiences on family/home stress likely take a significant toll on women in the fire service. Findings confirm and extend previous work suggesting there is a need to improve the mental and physical health of women FFs. Future work should examine the prospective relationship between discrimination/harassment and poor health outcomes and potential policies/practices to reduce these negative behaviors.
Dual‐band design of single‐stub impedance matching networks with application to dual‐band stubbed T‐junctions

A new design method of single‐stub impedance matching networks is presented for the dual‐band application. The dual‐band operating conditions are analyzed in detail and the design equations are derived in concise form for different locations and termination types of the stub line. The proposed impedance matching scheme is successfully applied to the design of a stubbed dual‐band T‐junction power divider. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1359–1362, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25201
Siglecs as Therapeutic Targets in Cancer

Simple Summary Hyperglycosylated cancer cells are often decorated with abundant sialic acids, which are recognized by Sialic acid binding immunoglobulin type lectins (Siglecs) expressed on immune cells. As sialic acids are normally expressed on almost all cell types, Siglecs can function as receptors for “self”. Presently, 15 human Siglecs (including non-sialic acid binding Siglec XII) are known, of which most are immunoinhibitory receptors that induce strong inhibitory signaling when Siglecs bind sialic acids. Hence, tumor cells use hyper sialic acid expression in their favor to modify the immune system that can lead to immune suppression. Such engagement along the Siglec-sialic acid axis can dampen major killing modes of effector immune cells and suppress the activation of immune responses, which can lead to immune tolerance and tumor growth. In this review, we emphasized recent studies on all 15 Siglecs found in humans, many of which still remain understudied. In addition, we highlighted different strategies in disrupting the surface Siglec-sialic acid interactions, including antibodies and glycan moieties, which can steer back antitumor immune responses to reduce tumor size and improve overall survival of cancer patients. Abstract Hypersialylation is a common post-translational modification of protein and lipids found on cancer cell surfaces, which participate in cell-cell interactions and in the regulation of immune responses. Sialic acids are a family of nine-carbon α-keto acids found at the outermost ends of glycans attached to cell surfaces. Given their locations on cell surfaces, tumor cells aberrantly overexpress sialic acids, which are recognized by Siglec receptors found on immune cells to mediate broad immunomodulatory signaling. Enhanced sialylation exposed on cancer cell surfaces is exemplified as “self-associated molecular pattern” (SAMP), which tricks Siglec receptors found on leukocytes to greatly down-regulate immune responsiveness, leading to tumor growth. In this review, we focused on all 15 human Siglecs (including Siglec XII), many of which still remain understudied. We also highlighted strategies that disrupt the course of Siglec-sialic acid interactions, such as antibody-based therapies and sialic acid mimetics leading to tumor cell depletion. Herein, we introduced the central roles of Siglecs in mediating pro-tumor immunity and discussed strategies that target these receptors, which could benefit improved cancer immunotherapy.
Influence of the material volume of a lattice structure on bending properties

The article deals with the experimental investigation of the influence of material volume of a lattice structure on bending stress. FDM (Fused Deposition modelling) technique and ABS (Acrylonitrile Butadiene Styrene) material were selected for the samples production. Three types of samples with the same simple lattice structure and the same size of a basic cell 5 mm, but differ in a material volume ratio, were analysed experimentally. Minimally six pieces of the samples of each volume ratio were produced and tested using the ZWICK 1456 testing machine at an ambient temperature of 22 °C and at a relative humidity of 60 % according to the standard EN ISO 604. The stress-strain diagrams have been plotted and the values of maximum stresses have been tabled. The measured data were statistically processed, and average values of bending stresses were calculated. Based on the results the behaviour of the structure has been mathematically described, while the results showed that the dependency has an exponential trend.
Role and Clinical Utility of Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma

Simple Summary In this review, we discuss the roles of cancer/testis antigens in the germline and their contributions to oncogenic cellular processes. Specifically, we focus on their clinical utility in head and neck squamous cell carcinoma and consider how cancer/testis antigens differentially expressed in HPV-positive HNSCC might contribute mechanistically to the genesis and clinical characteristics of these cancers. Abstract Cancer/testis (CT) antigens exhibit selective expression predominantly in immunoprivileged tissues in non-pathological contexts but are aberrantly expressed in diverse cancers. Due to their expression pattern, they have historically been attractive targets for immunotherapies. A growing number of studies implicate CT antigens in almost all hallmarks of cancer, suggesting that they may act as cancer drivers. CT antigens are expressed in head and neck squamous cell carcinomas. However, their role in the pathogenesis of these cancers remains poorly studied. Given that CT antigens hold intriguing potential as therapeutic targets and as biomarkers for prognosis and that they can provide novel insights into oncogenic mechanisms, their further study in the context of head and squamous cell carcinoma is warranted.
Inhibition of mTORC1 signaling in aged rats counteracts the decline in muscle mass and reverses multiple parameters of muscle signaling associated with sarcopenia

There is a lack of pharmacological interventions available for sarcopenia, a progressive age-associated loss of muscle mass, leading to a decline in mobility and quality of life. We found mTORC1 (mammalian target of rapamycin complex 1), a well-established critical positive modulator of mass, to be hyperactivated in sarcopenic muscle. Furthermore, inhibition of the mTORC1 pathway counteracted sarcopenia as determined by observing an increase in muscle mass and fiber type cross sectional area, surprising because mTORC1 signaling has been shown to be required for muscle mass gains in some settings. Additionally, several genes related to senescence were downregulated, while gene expression indicators of neuromuscular junction denervation were diminished using a low dose of a rapalog. Therefore mTORC1 inhibition may delay the progression of sarcopenia by directly and indirectly modulating multiple age-associated pathways, implicating mTORC1 as a therapeutic target to treat sarcopenia.
Antimicrobial resistance in Enterococcus faecium and Enterococcus faecalis isolates of swine origin from eighteen provinces in China

Enterococcus faecium and E. faecalis are important human pathogens and also served as sentinel organisms for monitoring systems of antimicrobial resistance in both animals and humans. In this study, 106 E. faecium and 56 E. faecalis isolates were collected from 61 pig farms in 18 proveinces of China. Antimicrobial susceptibility was determined for 9 clinically important antibiotics and 3 antimicrobial growth promoters. The Enterococcus isolates showed high prevalence of resistance to medically important antibiotics, such as ampicillin (50.9% for E. faecium and 19.6% for E. faecalis), chloramphenicol (24.5% for E. faecium and 41.1% for E. faecalis), erythromycin (83.0% for E. faecium and 91.1% for E. faecalis), tetracycline (79.2% for E. faecium and 100% for E. faecalis), quinupristin/dalfopristin (26.4% for E. faecium) and ciprofloxacin (73.6% for E. faecium and 66.1% for E. faecalis). Resistance to tigecycline, linezolid and vancomycin was very rare. The resistance status of three representative in-feed antibiotics bacitracin, nosiheptide and enramycin was firstly investigated with Enterococcus as indicator bacteria. The Enterococcus isolates showed extremely high frequency of bacitracin resistance (96.7% for E. faecium and 87.8% for E. faecalis), while no nosiheptide and enramycin resistance was observed. Pulsed-field gel electrophoresis (PFGE) analysis showed that a majority of E. faecium and E. faecalis strains showed unrelated profiles, indicating high heterogeneity among the Enterococcus isolates. Our study provided basic data on the antimicrobial resistance of E. faecium and E. faecalis isolates.
Eudragit-Coated Sporopollenin Exine Microcapsules (SEMC) of Phoenix dactylifera L. of 5-Fluorouracil for Colon-Specific Drug Delivery

In this study, 5-fluorouracil (5-FU)-loaded pollens of Phoenix dactylifera and their coating with ERS was done and evaluated for the colon-targeted delivery of 5-FU to treat colon cancer. Sporopollenin exine microcapsules (SEMC) from the pollens of Phoenix dactylifera were extracted by the reflux method and 5-FU into SEMC was encapsulated by the vacuum-assisted loading method. 5-FU loaded SEMC was coated with Eudragit® RS-100 (ERS) by the organic solvent-evaporation technique under vacuum to avoid the discharge of 5-FU in the stomach and small intestine. Morphological and physicochemical characterization of drug-loaded SEMC (coated/uncoated) was performed by scanning electron microscopy (SEM), FTIR, XRD, and DSC. The encapsulation and drug loading were determined by the direct method, and an in vitro release study was performed in simulated gastric and intestinal fluids (SGF/SIF). The colon-specific delivery of 5-FU from the SEMC was assessed in terms of pharmacokinetics and gastrointestinal tract distribution after oral administration in rats. The successful encapsulation and loading of 5-FU into SEMC by a vacuum-assisted loading technique and its coating with ERS by a solvent-evaporation technique were achieved. SEM images of uncoated SEMC have shown porous structures, and coating with ERS reserved their morphology with a smooth surface and discrete microstructures and the 5% w/v ERS acetone solution. ERS-coated SEMC sustained the release of 5-FU until 24 h in SIF, while it was up to 12 h only from uncoated SEMC. The maximum plasma concentration (Cmax) of 5-FU from uncoated SEMC was 102.82 μg/mL after 1 h, indicating a rapid release of 5-FU in the upper gastrointestinal tract. This concentration decreased quickly with a half-life of 4 h, AUC0-t was 264.1 μg/mL.h, and MRT0-inf was 5.2 h. The Cmax of 5-FU from ERS-coated SEMC was 19.47 μg/mL at 16 h. The Cmax of 5-FU in small intestines was 406.2 μg/g at 1 h from uncoated SEMC and 1271.5 μg/g at 12 h from coated SEMC. Conclusively, a 249.9-fold higher relative bioavailability of 5-FU was achieved with the ERS-coated SEMC in colon tissues than that from uncoated SEMC.
Parachute Models Used in the Mars Science Laboratory Entry, Descent, and Landing Simulation

An end-to-end simulation of the Mars Science Laboratory (MSL) entry, descent, and landing (EDL) sequence was created at the NASA Langley Research Center using the Program to Optimize Simulated Trajectories II (POST2). This simulation is capable of providing numerous MSL system and flight software responses, including Monte Carlo-derived statistics of these responses. The MSL POST2 simulation includes models of EDL system elements, including those related to the parachute system. Among these there are models for the parachute geometry, mass properties, deployment, inflation, opening force, area oscillations, aerodynamic coefficients, apparent mass, interaction with the main landing engines, and off-loading. These models were kept as simple as possible, considering the overall objectives of the simulation. The main purpose of this paper is to describe these parachute system models to the extent necessary to understand how they work and some of their limitations. A list of lessons learned during the development of the models and simulation is provided. Future improvements to the parachute system models are proposed.
An Integrated Robust Strategy for Diagnosing Sensor Faults in Building Chilling Systems

An integrated robust strategy for the detection, diagnosis, and validation of the soft sensor faults commonly found in building chilling systems is presented. The integrated strategy, which extends the works of Wang and Wang (1999), is based on the universal conservation relationships for mass and energy. Biases in temperature sensors and flow meters are estimated by minimizing the sums of the squares of the mass and energy balance residuals. A robust approach using a genetic algorithm is used to systematically minimize the sums of the squares of the associated heat balance residuals so that the biases are estimated more reliably and accurately. A correlation cancellation method is developed to estimate the cooling water flow meter bias, under conditions in which the cooling water temperature sensor biases exist and are unknown. The correlation cancellation method uses a derived characteristic quantity to estimate the water flow meter bias. Validation tests are performed using a dynamic simulation together with a field case study conducted in an existing building chilling system. Even in unfavorable conditions, the integrated robust strategy can estimate the biases of the chilled and cooling water flow meters and the relative biases of the chilled and cooling water temperature sensors accurately and robustly.
Intermetallic Differences at CdS–Metal (Ni, Pd, Pt, and Au) Interfaces: From Single-Atom to Subnanometer Metal Clusters

Metal co-catalysts tipped at a photocatalyst surface form a crucial component in the nanoheterostructures designed for the photocatalytic hydrogen evolution reaction. To examine the intermetallic differences and size effects at these interfaces, we use spin-polarized density functional theory to study single-atom, 13-atom, and 55-atom cluster depositions of Ni, Pd, Pt, and Au on the CdS(101̅0) surface. For the single metal atoms, the ground-state configuration was the same site for all of the elements. Analysis of the metal–CdS bonding and of the charge transfers revealed a Ni–Cd bonding complex leading to depletion of electronic charge at the Ni single atom and at deposited Ni clusters, in contrast to charge accumulation observed for the other three metals Pd, Pt, and Au. For scaling up sizes of the metal deposition, six subnanometer cluster types were selected over a wide range of cluster’s effective coordination number, and their interfaces were differentiated by charge redistributions, structure and adhesion energies, highest occupied molecular orbital–lowest occupied molecular orbital (HOMO-LUMO) gaps, and Schottky barrier heights. Although all considered clusters are semiconducting in the gas phase, 9 out of 28 clusters became (semi)metallic after deposition on the CdS semiconductor surface. Intermetallic differences and common trends are discussed.
Immobilization and experimental periodontitis in tibial anterior muscle of wistar rats

Introduction and objective. Periodontal disease (PD) is a chronic inflammation, locally attacking the supporting tissues of the tooth; this inflammatory condition can affect other systems, such as muscle tissue, which is also susceptible to several types of injury such as caused by immobilization. The aim of this study was to assess whether periodontal disease potentiates the deleterious effects of immobilization of the anterior tibial muscle of Wistar rats. Materials and method. Twenty animals were randomly assigned to four groups (n=5): Control Group (CG), Periodontal Disease Group (PDG), Immobilized Group (IG) and PD plus Immobilization Group (PDIG). PD was induced on day 1 of the experiment by placing a cotton thread in the first lower molars for 30 days, favouring the accumulation of bacterial plaque. On day 15, the right pelvic limb was immobilized for 15 days. On day 30, the animals were euthanized and the tibialis anterior muscle was collected with further processing for histomorphometric analysis. Results. In the cross-sectional area there were PDIG differences between CG and PDG. For the larger diameter, CG was higher than IG and PDIG. For the smaller diameter, PDIG presented a lower value among all the groups in the same way with the number of nuclei. For connective tissue, there was an increase in the amount between the CG and PDIG, IG and PDIG groups, as well as PDG and PDIG. Conclusion. Periodontal disease potentiated the deleterious effects of immobilization on the anterior tibialis muscle.