Miracle-dz/UniFAR-FTUs huggingface dataset:
Nutritional and dietary interventions for the treatment of Chronic Fatigue Syndrome

Background: Chronic fatigue syndrome is an increasingly frequent disorder characterized by prolonged fatigue and few specific symptoms. He favors prolonged stress and life in a constant hurry. The main symptoms of chronic fatigue include: headache, throat, myalgia, joint pain, short-term memory impairment, sleep disorders, malaise occurring after physical exertion and lasting over 24 hours, and painful lymph nodes. The possibility of chronic fatigue syndrome should be considered in patients with the above symptoms, if they persist for more than 6 months. In this review, we wanted to focus on the possibilities to minimize the symptoms of chronic fatigue syndrome through nutritional and dietary intervention. Materials and methods: Analysis of articles in the EBSCO and Google Scholar database using Results: Patients with chronic fatigue syndrome suffer from chronic fatigue and not specific symptoms, which makes diagnosis difficult. The analysis of articles shows that dietary and nutritional interventions tailored to the patient reduce the feeling of fatigue, which is the main problem among patients with chronic fatigue syndrome. Positive effects in the form of alleviation of symptoms have been observed while using, inter alia: polyphenols, L-carnitine, probiotics, CoQ10 and NADH and GAA. Conclusions: Dietary and nutritional intervention has a positive effect on intestinal microflora, intestinal mucosa, oxidative stress and proper functioning of mitochondria, thanks to which it reduces symptoms of chronic fatigue syndrome. Individual and appropriate supplementation depending on the etiology of the syndrome can lead to relief of symptoms. conducted a study on the concentration of IgA and IgM in LPS gram-negative enterobacteria in patients suffering from CFS before and after taking NAIOS with a leaky gut diet during 10-14 months. Immunological changes and Fatigue Team Fatigue Scale were measured in 41 patients with CFS before and 10-14 months after NAIOS. Studies show that consumption of certain NAIOS weakens the IgM and IgA responses to LPS - NAIOS may be considered to reduce NAIOS intestinal inflammation (glutamine, NAC, zinc) are suitable for the treatment of increased intestinal permeability. Glutamine has the properties of alleviating intestinal damage. The studies proved that glutamine reduces the frequency of pancreatic infections, reduces the flow of mannitol through the epithelium and, above all, increases resistance to mucous membranes. translocations. intestinal barrier functions. NAC eliminates inflammation that comes from the gastrointestinal tract due to increased intestinal barrier function. NAIOS that study:
A Nonlinear Conservation Law with Memory.

Abstract : In this paper we study a history-boundary value problem for a nonlinear conservation with fading memory in one space dimension. The motivation for studying this problem is an earlier work by C. M. Dafermos and the author concerning the motion of a nonlinear, one-dimensional viscoelastic body. Using a variant of an energy method applied to the viscoelastic problem it is shown that under physically reasonable assumptions the nonlinear conservation law has a unique, classical solution (global in time), provided the data are sufficiently smooth and 'small' in a suitable norm; moreover, the solution and its first order derivatives decay to zero as t goes to infinity. The proof illustrates the versatility of the energy method combined with frequency domain techniques for Volterra operators. A preliminary analysis based on current work of R. Malek-Madani and the author is presented concerning the development of singularities in smooth solutions of the conservation law (in finite time) for sufficiently 'large' smooth data; under special assumptions it is shown that such singularities necessarily develop. The hope is to apply such a procedure to the viscoelastic problem. (Author)
The nature of assembly bias – I. Clues from a ΛCDM cosmology

We present a new proxy for the overdensity peak height for which the large-scale clustering of haloes of a given mass does not vary significantly with the assembly history. The peak height, usually taken to be well represented by the virial mass, can instead be approximated by the mass inside spheres of different radii, which in some cases can be larger than the virial radius and therefore include mass outside the individual host halo. The sphere radii are defined as r = aδ t + b log 10 (M vir /M nl ) , where δ t is the age relative to the typical age of galaxies hosted by haloes with virial mass M vir , M nl is the non-linear mass, and a = 0.2 and b = -0.02 are the free parameters adjusted to trace the assembly bias effect. Note that r depends on both halo mass and age. In this new approach, some of the objects which were initially considered low-mass peaks (i.e. which had low virial masses) belong to regions with higher overdensities. At large scales, i.e. in the two-halo regime, this model properly recovers the simple prescription where the bias responds to the height of the mass peak alone, in contrast to the usual definition (virial mass) that shows a strong dependence on additional halo properties such as formation time. The dependence on the age in the one-halo term is also remarkably reduced with the new definition. The population of galaxies whose 'peak height' changes with this new definition consists mainly of old stellar populations and are preferentially hosted by low-mass haloes located near more massive objects. The latter is in agreement with recent results which indicate that old, low-mass haloes would suffer truncation of mass accretion by nearby larger haloes or simply due to the high density of their surroundings, thus showing an assembly bias effect. The change in mass is small enough that the Sheth et al. mass function is still a good fit to the resulting distribution of new masses.
Aortic Stiffness

We read with interest the letter by Drs. Rafique and Siegel, and thank them for their comments. In our subpopulation of surgical patients, they show if one uses the additional criterion of a left ventricular enddiastolic dimension (LVEDD) $55 mm, concordance between echocardiography and magnetic resonance imaging (MRI) improves from 32% to 58%. They conclude LVEDD should be a key parameter in the echocardiographic assessment of chronic mitral regurgitation (MR). It is well accepted that chronic MR causes an increase in LV size. We previously used this important relationship to validate the accuracy of MRI for quantifying regurgitant volume (1). We showed a tight coupling between MR regurgitant volume and LV enddiastolic volume (r 1⁄4 0.8), but this study was limited to patients with isolated, primary MR. Using LV size as an additional criterion may improve the accuracy of echocardiography in a population of patients, but it is no substitute for the accurate determination of MR severity in an individual patient. This is because many other common diseases and conditions affect LV size. Myocardial infarction, nonischemic cardiomyopathy, and athletic heart can substantially increase LV size without increasing MR. Similarly, diseases such as restrictive cardiomyopathy and aortic stenosis can substantially decrease LV size without decreasing MR. Table 4 shows the limitations of using LVEDD as a criterion for MR severity (2). For example, patient #29 had an LVEDD of 62 mm, yet had mild MR, and patient #38 had an LVEDD of 53 mm, yet had severe MR. Using LV size as a surrogate to avoid overestimation of MR severity is similar to the strategy advocated by some, to delay surgery until patients are symptomatic. The thought being that the presence of symptoms avoids the possibility of inappropriate surgery in MR patients that are mistakenly graded as severe (3). However, as is the case with using any surrogate, a potential problem is the possibility of confounding illnesses, especially when they are common. Consider 2 relatively common conditions: mild MR and restrictive cardiomyopathy. A patient with symptomatic restrictive cardiomyopathy and mild MR that is mistakenly graded as severe by echocardiography is at high risk of undergoing inappropriate surgery. In summary, we believe echocardiographers should use all information available to them, including LV size, to determine MR severity. However, given the potential inaccuracy of echocardiography, and the cost and complications of open heart surgery, we are steadfast in our conclusion that cardiac MRI should be a strong consideration when important clinical decisions are being made based on MR severity, even in the presence of symptoms.
Kindergartners Planning in the Design Process: Drawn Plans and how they Relate to First Try Design Attempts (Fundamental)

mechanical engineering, as a process engineer, taught high school physics and pre-engineering. She has taught engineering and science to children in multiple formal and informal settings. As a K-8 pre-service teacher educator, she includes engineering in her elementary and early childhood science methods courses and developed and taught an engineering methods course for middle school teachers. She also developed a graduate-level engineering education course for PreK-6 teachers. Dr. Lottero has provided professional learning experiences in multiple schools and school systems in Maryland. She has co-authored numerous engineering-focused articles for the teacher practitioner journal, Science and Children, and presents her research regularly through the American Society for Engineering Education. Her current research includes investigating how K-5 students plan, fail, and productively persist. She is the Director of the Integrated STEM Instructional Leadership (PreK-6) Post-Baccalaureate Certiﬁcate Program at TU. She currently serves as the Immediate Past Chair of the Pre-College Engineering Education Division of ASEE. and pedagogy interested in and
perspectives Realizing the potential of zebraﬁsh as a model for human disease

Realizing the potential of zebraﬁsh as a model for human disease. Physiol Genomics 2: 49–51, 2000. —The value of the zebraﬁsh ( Danio rerio ) as a model for human disease has been substantiated by a number of recently published papers. Several zebraﬁsh mutants with ‘‘human’’ diseases have been found, spanning a variety of human pathologies. These successful studies utilizing the zebraﬁsh have been made possible by the development of key reagents such as YAC, PAC, and BAC libraries, as well as radiation hybrid panels. With the further establish-ment of new tools and access to the newly generated re-sources, the zebraﬁsh is poised to serve as a novel model for human disease.
Flux-limited diffusion theory with anisotropic scattering

The Chapman-Enskog procedure of kinetic theory is used to obtain a flux-limited diffusion theory for linear transport problems. The analysis is carried out within the context of multigroup theory, with an arbitrary scattering matrix involving anisotropic effects for both within-group and group-to group scattering. Aside from the question of flux limiting, a new definition of the transport cross section arises naturally from the analysis.
International Journal of Advanced Research in Computer Science and Software Engineering

-Tremendous amount of data being collected is increasing speedily by computerized applications around the world. Hidden in the vast data, the valuable information is attracting researchers of multiple disciplines to study effective approaches to derive useful knowledge from within. Among various data mining objectives, the mining of frequent patterns has been the focus of knowledge discovery in databases. This paper aims to investigate efficient algorithm for mining sequential patterns. Mining sequential patterns with time constraints, such as time gaps and sliding time-window, may reinforce the accuracy of mining results. However, the capabilities to mine the time-constrained patterns were previously available only within Apriori framework. Recent studies indicate that pattern-growth methodology could speed up sequence mining. Current algorithms use a generate-candidate-and-test approach that may generate a large amount of candidates for dense datasets. Many candidates do not appear in the database. Therefore we are introducing a more efficient algorithm for sequential pattern mining. The time & space consumption of proposed algorithm will be lesser in comparison to previous algorithm.
Review of indicators on active ageing towards sustainable development in Thailand

There is a growing importance in the research of longevity, active ageing and its indicators as ageing has profound social and economic consequences in the 21st century with implications for nearly all sectors of society. The 2030 Agenda for Sustainable Development sets out a universal plan of action to achieve sustainable development in a balanced manner and seeks to realize the human rights of all people. This article reviews previous studies on active ageing with an aim to explore the indicators of active ageing towards sustainable development in Thailand. There is a growing need of ageing people to be included as the active agents of societal development goals in order to achieve truly transformative, inclusive and sustainable development outcomes. For achieving these goals, research studies are needed to explore the indicators for active ageing, community participation, health improvement, social security, and societies or policy makers should provide enabling environments for them to do so. As populations become increasingly aged, it is more important than ever that governments design innovative policies and public services specifically targeted to older persons, including those addressing, housing, employment, health care, infrastructure and social protection [1]. The implications of this paper are expected to be beneficial in individual, academic and organizations.
Surfactant effect on the bubble motions and bubbly flow structures in a vertical channel

It is well known that a small amount of surfactant can drastically change the motion of a single bubble and this causes a dramatic change of the whole bubbly flow structure. In our previous studies using upward vertical channel flows, it was shown that surfactant influences the shear-induced lift and the lateral migration of a bubble, which causes bubble accumulation and clustering near the wall. In this paper, the dependence of surfactant concentration on the motions of a 1 mm bubble rising through the laminar shear flow is investigated using 1-, 3-Pentanol and Triton X-100. The results are compared with the numerical ones, which show quantitative agreement on the lift and drag forces. Furthermore, we analyze the experimental data for the condition of bubble clustering in upward channel flows with the consideration of contaminant level in tap water. The results indicate that lower contaminant level and higher shear rate cause the significant bubble migration toward the wall, which leads to the formation of bubble clusters.
Harmonic Suppression in Nonlinear Systems

Atomic Force Microscopy is a highly sensitive method that uses a mi-croscopic cantilever to measure minute forces with nanometer precision. The method is successfully used to image and characterize a variety of samples by the interaction force created between a sharp tip and surface. When the sample is immersed in liquid one is faced with the challenge of a highly nonlinear force distribution. This project describes and addresses a few of the challenges encountered in trying to interpret this nonlinear interaction force and thus make measurements in liquid more precise. The project builds upon and extends ongoing research to expand the applicability of AFM through faster and more accurate force measurements. The work performed focuses on implementing a structured data acquisition as well as performing and analyzing new modes of actuating the AFM cantilever. To make force reconstruction in liquids more accurate we propose a new method of exciting the cantilever and we propose a method of mitigating the negative eﬀect this drive scheme may have on the image quality.
The Role of the Glutamate, Metabotropic Glutamate Receptors and their Antagonists in Nociception

Presence of metabotropic receptors in dorsal horns of the spinal cord neurons stated that after intraventricular intrathecal use of specific antagonists for mGluR1 receptors reveals analgetic activity both in rodents and large mammals. Knockdown of spinal mGluR1 receptors soothes pain and restores effectiveness of opioids activity after damage of the nerve in rats. Recently published researches proved that mice which were deprived of endothelin-3 in rectum on Hirschprung disease model lose selectively the ability to feel visceral pain. Qi and co-workers, suggest special participation of tension-dependent Na + and Ca 2+ channels in visceral pain feeling whereas use of these channels antagonists can contribute to new possibilities in visceral pain therapy. Results of our research interchangeably indicate that used centrally nonspecific mGluRgroup I receptor antagonist – which is racemic form of DL-AP3 – impedes transmission of nocifensive impuls induced by 5 min mechanical distension of descending colon wall in sheep. It also prevents from cascade of behavioural, clinical and neuroendocrine phenomena released in sharp visceral pain by mechanical impuls. DL-AP3 can be recommended in soothing of intestines colic symptoms in sheep provided that similar effects after peripheral usage of that racemate will be confirmed.
G βγ binds to the extreme C-terminus of SNAP25 to mediate the action of G i/o -coupled GPCRs.

G i/o -coupled G-protein coupled receptors (GPCRs) can exert an inhibitory effect on vesicle release through several G-protein driven mechanisms, more than one of which may be concurrently present in individual presynaptic terminals. The synaptosomal-associated protein of 25 kDa (SNAP25) is a key downstream effector of G protein betagamma (G βγ ) subunits. It has previously been shown that proteolytic cleavage of SNAP25 by botulinum toxin A (BoNT/A) reduces the ability of G βγ to compete with the calcium sensor synaptotagmin 1 (Syt1) for binding to SNAP25 in a calcium-dependent manner. These truncated SNAP25 proteins sustain a low level of exocytosis but are unable to support serotonin-mediated inhibition of exocytosis in lamprey spinal neurons. Here, we generate a SNAP-5 extreme C-terminal mutant that is deficient in its ability to bind G βγ while retaining normal calcium-dependent Syt1 binding to SNARE and vesicle release. The SNAP25 Δ 3 mutant, in which residue G204 is replaced by a stop codon, features a partial reduction in G β 1 γ 2 binding in vitro as well as a partial reduction in the ability of the lamprey 5HT 1b -type serotonin receptor to reduce excitatory postsynaptic current (EPSC) amplitudes, an effect previously shown to be mediated through the interaction of G βγ with SNAP25. Syt1 calcium-dependent binding to SNAP25 Δ 3 was reduced by a small extent compared to wild-type. We conclude that the extreme C-terminus of SNAP25 is a critical region for the G βγ -SNARE interaction.
Effects of Localized Application of Transforming Growth Factor (II on Developing Chick Limbs

The effects of exogenous transforming growth factor fl (TGF-P) on chick limb development in z$vo were studied by implanting carriers of TGF-@1 into developing wing buds. Agarose beads were soaked in solutions containing TGF-Pl and implanted into wing buds at stages 18 to 27. Localized application of TGF-01 to distal regions of the wing bud caused specific skeletal elements in the limb to be reduced or absent. The particular proximal-distal limb element affected depended on the stage at which the bead was implanted. Position of the bead in the anterior-posterior axis also influenced the pattern of affected structures. Experiments in which TGF-fil beads were implanted and then removed at 24- and 48-hr intervals indicate that there are specific periods during which a skeletal element appears to be sensitive to the effects of exogenous TGF-01. In a few cases, beads placed in proximal positions in later staged limbs resulted in formation of ectopic cartilage near the bead. These results suggest that exposure to exogenous TGF-61 in t:i~o influences the development of skeletal elements in the chick limb in a stage- and position-dependent manner.
Formal Modeling of Cyber-Physical System for Conveyor Sorter

Conveyor is usually used in materials handling in manufacturing. Conveyor able to transfer the product from one to another place. In order to use concept of Cyber Physical System (CPS), conveyor have to represent itself to user in cyber and physical. CPS is a communication between cyber and physical of product in real-time system which is user can control the conveyor by using cyber or manually. In this paper, we focused on three goals which are to design CPS model for manufacturing application, modelling the system by using concept Object-Oriented (OO) in any OO software and verification on model using model-checking method. This paper proposes conveyor system as the model for manufacturing. We represent the model as cyber conveyor according to physical conveyor and proposed the methodology how they communicate each other in real time.
Differential Impact of the rpoB Mutant on Rifampin and Rifabutin Resistance Signatures of Mycobacterium tuberculosis Is Revealed Using a Whole-Genome Sequencing Assay

Current approaches to diagnose drug-resistant MTB are time-consuming, consequently leading to inefficient intervention or further disease transmission. In this study, we curated lists of coding variants associated with differential rifampin and rifabutin resistant signatures using a single molecule real-time (SMRT) sequencing platform with a shorter hands-on time. ABSTRACT Drug resistance in Mycobacterium tuberculosis (MTB) has long been a serious health issue worldwide. Most drug-resistant MTB isolates were identified due to treatment failure or in clinical examinations 3~6 months postinfection. In this study, we propose a whole-genome sequencing (WGS) pipeline via the Nanopore MinION platform to facilitate the efficacy of phenotypic identification of clinical isolates. We used the Nanopore MinION platform to perform WGS of clinical MTB isolates, including susceptible (n = 30) and rifampin- (RIF) or rifabutin (RFB)-resistant isolates (n = 20) according to results of a susceptibility test. Nonsynonymous variants within the rpoB gene associated with RIF resistance were identified using the WGS analytical pipeline. In total, 131 variants within the rpoB gene in RIF-resistant isolates were identified. The presence of the emergent Asp531Gly or His445Gln was first identified to be associated with the rifampin and rifabutin resistance signatures of clinical isolates. The results of the minimum inhibitory concentration (MIC) test further indicated that the Ser450Leu or the mutant within the rifampin resistance-determining region (RRDR)-associated rifabutin-resistant signature was diminished in the presence of novel mutants, including Phe669Val, Leu206Ile, or Met148Leu, identified in this study. IMPORTANCE Current approaches to diagnose drug-resistant MTB are time-consuming, consequently leading to inefficient intervention or further disease transmission. In this study, we curated lists of coding variants associated with differential rifampin and rifabutin resistant signatures using a single molecule real-time (SMRT) sequencing platform with a shorter hands-on time. Accordingly, the emerging WGS pipeline constitutes a potential platform for efficacious and accurate diagnosis of drug-resistant MTB isolates.