Miracle-dz/UniFAR-FTUs huggingface dataset:
A new species of Leptomyrina Butler, 1898 (Lepidoptera: Lycaenidae) from Mts Mecula, Namuli, Inago, Nallume and Mabu in Northern Mozambique

This paper describes a new species of Leptomyrina from five mountains in northern Mozambique – Mts Mecula, Namuli, Inago, Nallume and Mabu. Specimens were collected over the course of several years between 2007 and 2019 through a series of biodiversity surveys of the mountains of northern Mozambique. This species differs from others in the group based on the rounded and tail-less shape of the hindwing, and the dusting of powder blue scales on the upper side of the males. The genitalia also show significant differences to others in the group. It is found towards the summits of these mountains at elevations generally over 1000m and feeds on Crassulaceae.
Preventing Bacterial Translocation in Patients with Leaky Gut Syndrome: Nutrition and Pharmacological Treatment Options

Leaky gut syndrome is a medical condition characterized by intestinal hyperpermeability. Since the intestinal barrier is one of the essential components maintaining homeostasis along the gastrointestinal tract, loss of its integrity due to changes in bacterial composition, decreased expression levels of tight junction proteins, and increased concentration of pro-inflammatory cytokines may lead to intestinal hyperpermeability followed by the development of gastrointestinal and non-gastrointestinal diseases. Translocation of microorganisms and their toxic metabolites beyond the gastrointestinal tract is one of the fallouts of the leaky gut syndrome. The presence of intestinal bacteria in sterile tissues and distant organs may cause damage due to chronic inflammation and progression of disorders, including inflammatory bowel diseases, liver cirrhosis, and acute pancreatitis. Currently, there are no medical guidelines for the treatment or prevention of bacterial translocation in patients with the leaky gut syndrome; however, several studies suggest that dietary intervention can improve barrier function and restrict bacteria invasion. This review contains current literature data concerning the influence of diet, dietary supplements, probiotics, and drugs on intestinal permeability and bacterial translocation.
Recent weakening linkage between Arctic oscillation and Aleutian low during boreal winter and its impact on surface temperature over Eastern Eurasia

We investigated interdecadal relationship changes between the Arctic oscillation (AO) and Aleutian low (AL) for the period 1980–2021 along with the linkage on surface air temperature (SAT) over Eastern Eurasia during the boreal winter (December–January–February). The AO–AL relationship has weakened since the mid‐1990s. To explore a possible explanation, we compared atmospheric fields for two contrasting periods, one when the AO–AL relationship is the strongest (1986–2006) and one when it is the weakest (2000–2020). In both periods, atmospheric circulation over the Arctic region for the two AO–AL in‐phase relationships (i.e., either +AO/+AL or –AO/−AL) evolves with negative AO‐like patterns, contributing to a weakening AO–AL relationship in concurrent with a cool SAT in Eastern Eurasia. We found that the correlation between AL and SAT over Eastern Eurasia decreases, while the AO and SAT correlation remains unchanged. This implies that low‐frequency atmospheric circulation changes such as those of the AO and AL should be considered when studying SAT changes in Eastern Eurasia.
Temperature–humidity–bias testing on insulated-gate bipolartransistor modules – failure modes and acceleration due to high voltage

The temperature–humidity–bias (THB) test is the standard for accelerated stress testing with respect to corrosion and other humidity driven degradation mechanisms. Usually, 1000 h tests at 85°C and 85% relative humidity are used to predict up to 25 years of operation. The bias is usually limited to 80 V in order to fulfil the respective standards. Nevertheless, THB tests on 1700 V insulated-gate bipolar transistor (IGBT)-modules have shown that higher bias is a more severe test condition. The failure analysis confirmed Cu- and Ag-dendrites and corrosion of the aluminium (Al)-chip-metallisation as the relevant failure mechanisms. To determine the acceleration factor due to voltage, 1200 V IGBT modules were tested in THB at 780 V (65% of V CES) and 1080 V (90% of V CES). A characteristic degradation consisting of three phases has been identified. The second phase seems to be determined by Al corrosion and an acceleration factor of about two has been estimated from 780 to 1080 V. Within the third phase, the devices stabilised probably due to localised self-heating. Thus, this degradation mechanism is kind of self-limiting, but the higher leakage also increases the risk of thermal runaway especially when biased close to the rated collector–emitter voltage.
Simple and multiple ordered correspondence analysis to evaluate customer satisfaction

In marketing research, to evaluate customer satisfaction, individuals are often required to fill in questionnaires where responses are ordered. To analyze the association of these ordered categorical variables, an alternative method to the usual multiple correspondence analysis has been adopted. It is based not only on the classic singular value decomposition but on a hybrid decomposition.
p-GaN Gate HEMTs With 10.6 V Maximum Gate Drive Voltages by Mg Doping Engineering

We present a novel p-gallium nitride (GaN) gate HEMT structure with reduced hole concentration near the Schottky interface by doping engineering in metal-organic chemical vapor deposition (MOCVD), which aims at lowering the electric field across the gate. By employing the additional unintentionally doped GaN (u-GaN) layer, the gate leakage current is suppressed and the gate breakdown voltage is boosted from 10.6 to 14.6 V with negligible influence on the threshold voltage and ON-resistance. A reduced Mg concentration in the u-GaN layer was confirmed by secondary-ion mass spectrometry. Time-dependent gate breakdown measurements reveal that the maximum gate drive voltage increases from 6.2 to 10.6 V for a ten-year lifetime with a 1% gate failure rate, which effectively expands the operating voltage margin of the p-GaN gate HEMTs without any other additional process step.
Effect of the plant flavonoid, rhoifolin, on memory and cognition in a rat model of Alzheimer’s disease

Purpose: To investigate the neuroprotective effect of the natural flavonoid rhoifolin in rats with streptozotocin (STZ)-induced (AD). Methods: Morris water-maze and novel object recognition tests were carried out to estimate the effect of rhoifolin on memory and cognition. Histopathological analysis was made to observe thickness of hippocampal CA1 pyramidal layer. Analysis of oxidative stress markers was performed to estimate the effect of rhoifolin on oxidative stress in the hippocampus and frontal cortex. Results: Morris water maze and novel object recognition tests showed a significant improvement in the memory, cognition and spatial learning in rhoifolin treated AD animals (p < 0.05). Moreover, rhoifolin treatment resulted in a significant increase in the CA1 pyramidal layer of AD animals indicating its neuroprotective properties (p < 0.05). The increase in the hippocampal CA1 area further validated the reversal of cognitive dysfunctions caused by STZ treatment. Furthermore, analysis of oxidative stress markers SOD, CAT, GPX, GRX, and MDA showed a significant improvement in the oxidative stress in the hippocampus and frontal cortex (p < 0.05). Conclusion: The present study is the first report to demonstrate the effect of plant flavonoid, rhoifolin on STZ-induced AD in rat model. Rhoifolin improves spatial learning, cognition, and memory in STZ-treated rat model. Therefore, rhoifolin may be a promising therapeutic agent for the management of AD.
Circulating Thrombomodulin: Release Mechanisms, Measurements, and Levels in Diseases and Medical Procedures

Thrombomodulin (TM) is a type-I transmembrane protein that is mainly expressed on endothelial cells and plays important roles in many biological processes. Circulating TM of different forms are also present in biofluids, such as blood and urine. Soluble TM (sTM), comprised of several domains of TM, is the major circulating TM which is generated by either enzymatic or chemical cleavage of the intact protein under different conditions. Under normal conditions, sTM is present in low concentrations (<10 ng/mL) in the blood but is elevated in several pathological conditions associated with endothelial dysfunction such as cardiovascular, inflammatory, infection, and metabolic diseases. Therefore, sTM level has been examined for monitoring disease development, such as disseminated intravascular coagulation (DIC), sepsis and multiple organ dysfunction syndrome in patients with novel coronavirus disease 2019 (COVID-19) recently. In addition, microvesicles (MVs) that contain membrane TM (MV-TM) have been found to be released from activated cells which also contribute to levels of circulating TM in certain diseases. Several release mechanisms of sTM and MV-TM have been reported, including enzymatic, chemical, and TM mutation mechanisms. Measurements of sTM and MV-TM have been developed and explored as biomarkers in many diseases. In this review, we summarize all these advances in three categories as follows: (1) release mechanisms of circulating TM, (2) methods for measuring circulating TM in biological samples, and (3) correlation of circulating TM with diseases. Altogether, it provides a whole picture of recent advances on circulating TM in health and disease.
Multiphysics Numerical Modeling of Transient Transport of PFAS

The need to understand the fate and transport of Per-and Polyfluoroalkyl substances (PFAS) has grown due to the widespread contamination of the environment by them. PFAS are persistent, mobile, toxic manmade chemicals of great concern that contribute to the contamination of soil and groundwater. The presence of PFAS in unsaturated soil complicates their transport due to the impact of the air-water interface and solid-phase adsorption. The air-water interface can significantly increase the retention of PFAS during its transport. In this paper, a numerical model has been developed to study the transport of PFAS by coupling transient seepage and advection-dispersion, also accounting for the air-water interface and solid-phase adsorption. The numerical model was then used to study various scenarios.
1st Workshop on Diversity, Accessibility and Inclusivity in Cyber Security

Diversity, Accessibility and Inclusivity are important considerations for cyber security, to ensure that security mechanisms are suitable for all users, who could have differing abilities as a result of physical or cognitive impairments. One way this can be achieved is by implementing accessible authentication, which is recommended as part of the Web Content Accessibility Guidelines (WCAG 2.1) defined by the World Wide Web Consortium (W3C). There have been recent examples where authentication has presented challenges for people with disabilities (BBC News, 2020). Other considerations include, deriving heuristics during the design of systems, to ensure that the accessibility requirements of potential users are satisfied. This Workshop will investigate the recent developments that aim to ensure cyber security is accessible and inclusive to all users. It will discuss the methods that can be implemented to develop such systems. It will also become a forum for researchers in the domains of accessibility, cyber security, human computer interaction, human centred design and System of Systems. Discussions during the Workshop will lead to the creation of a road map to enhance the diversity, accessibility and inclusivity of cyber security. Accessibility
An Input-Independent Loop Type-III Buck Converter With PSRR Improvement and EMI Suppression for Enhancing the Security of Edge Devices

This letter proposes an input-independent loop type-III buck converter (ILT3C) enhancing the security of edge devices. Compared to a conventional type-III buck converter, the ILT3C maximally improves power-supply rejection ratio as much as 34.1 dB to be robust against power injection attack. It also reduces the peak of electromagnetic interference as much as 35.8 dBμV to enhance the security from power side-channel attack. Furthermore, the external components such as an inductor and a capacitor of the converter should be integrated into a package to minimize its exposure to unknown hacking risks. Thus, the proposed converter operates with a high switching frequency (fsw) of 20 MHz and it can reduce the size of the external components enough to be placed in the package. The prototype converter was implemented in a 0.18-μm CMOS process. This ILT3C achieves the maximum efficiency of 90.7% and occupies an active area of 0.195 mm2.
Metabolic effects of adding Topiramate on Aripiprazole in bipolar patients aged between 6-18 years, a randomized, double-blind, placebo-controlled trial

Background: second-generation antipsychotics (SGAs) are associated with metabolic side effects in child and adolescents. The aim of this study is to evaluate the metabolic effects of adding topiramate on aripiprazole in patients with bipolar disorder (BD) aged between 6 and 18 years. Materials and Methods: A 12-week, double-blind, placebo-controlled, randomized trial was conducted in the child psychiatric units of university hospitals. Forty patients aged between 6 and 18 years with new diagnosis of BD participated in the study. Eleven patients were excluded. Subjects received aripiprazole plus topiramate (Group 1, n = 15) or aripiprazole (Group 2, n = 14) for a 3-month period. Young mania rating scale (YMRS) was used for measuring the manic symptoms severity. Primary outcome measures included weight, height, body mass index (BMI), waist circumference, abdominal circumference, and blood pressure. Secondary outcome measures included fasting blood glucose, hemoglobin A1C, fasting insulin, and fasting lipid profile. Changes in metabolic profile during the study were obtained by using repeated measures of variance. Results: During a 3-month follow-up, YMRS measures decreased significantly in both groups with a significant difference between groups (P < 0.05). The mean of weight, BMI, and high-density lipoprotein levels in group 2 were significantly increased (P < 0.05), and the mean of low-density lipoprotein level in group 1 was decreased (P < 0.05). No significant differences were observed in anthropometric parameters and metabolic indices between groups (P > 0.05). Conclusion: Adding topiramate on aripiprazole is effectivefor controlling bipolar disorder as well as metabolic adverse effects of SGAs in juvenile patients.
Predicting the Force Map of an ERT-Based Tactile Sensor Using Simulation and Deep Networks

Electrical resistance tomography (ERT) can be used to create large-scale soft tactile sensors that are flexible and robust. Good performance requires a fast and accurate mapping from the sensor’s sequential voltage measurements to the distribution of force across its surface. However, particularly with multiple contacts, this task is challenging for both previously developed approaches: physics-based modeling and end-to-end data-driven learning. Some promising results were recently achieved using sim-to-real transfer learning, but estimating multiple contact locations and accurate contact forces remains difficult because simulations tend to be less accurate with a high number of contact locations and/or high force. This paper introduces a modular hybrid method that combines simulation data synthesized from an electromechanical finite element model with real measurements collected from a new ERT-based tactile sensor. We use about 290 000 simulated and 90000 real measurements to train two deep neural networks: the first (Transfer-Net) captures the inevitable gap between simulation and reality, and the second (Recon-Net) reconstructs contact forces from voltage measurements. The number of contacts, contact locations, force magnitudes, and contact diameters are evaluated for a manually collected multi-contact dataset of 150 measurements. Our modular pipeline’s results outperform predictions by both a physics-based model and end-to-end learning. Note to Practitioners–ERT-based tactile sensors use high-speed voltage measurements from electrodes distributed over a piezoresistive area to output a force map that shows where contact is occurring, and how strong each contact is. Such sensors hold promise for giving robots and other devices a sense of touch over large surfaces with low hardware complexity. However, the software problem of converting voltages to an accurate force map has not previously been solved well, requiring either extensive model calibration or extensive contact data collection. This paper suggests a hybrid approach where a straightforward physics model simulates multi-contact experiments that are too costly to acquire in reality and a practical automatic indentation setup acquires real but geometrically limited multi-contact data. Although the number of real measurements required to learn the discrepancy between the sensor and the model is still large due to the inherent inverse nature of ERT-based tactile sensors, our combination of simulation and deep networks achieves better performance than either physical modeling or learning alone. This approach can advance practical large-area tactile sensing for industrial automation systems where multiple contacts occur, such as in manufacturing and assistive robotics. It could also likely be adapted to other nonlinear inverse problems.
The Effect of Volatile Oils on De-Bonding of Polycarbonate Bracket Reinforced with Ceramic Filler: A Quantitative Study (Part 1)

Introduction: The introduction of esthetic brackets is a new clinical approach in the field of orthodontics. Two main types of esthetic brackets have been developed and became widely available; the polycarbonate brackets, and the ceramic brackets. Both types have faced two significant de-bonding problems: (1) enamel and bracket fracture. The two problems have been well documented and continue to be of concern to clinicians. Aim: The aim of this in vitro study was to evaluate quantitatively the effect of three volatile oils and their combinations on the de-bonding of ceramic brackets. Material and Method: Polycarbonate brackets reinforced with ceramic filler were bonded to one hundred and eighty (180) sound extracted human premolars using Transbond XT light curing adhesive. The teeth were then distributed into the following groups according to the type of volatile oil and period of application: clove oil (5 & 30 minutes), peppermint oil (5 & 30 minutes), Black seed volatile oil (5 & 30 minutes), and mixture of peppermint + Black seed volatile oils (5 & 30 minutes) in addition to control group. The brackets were then de-bonded using the Instron Universal Testing Machine and the de-bonding force was recorded for each type of the volatile oils in different times of application. Result: The result revealed that the Black seed volatile oil gave the lowest de-bonding force in 5 minutes and 30 minutes of application whereas the mixture of the Black seed oil + peppermint oils gave the highest force in both time of application. Further, the peppermint oil application for 5-minute was found to be in the second rank whereas the Clove oil was in the third rank. Furthermore, in the 30 minutes of application the Clove oil was in the second rank whereas the peppermint was found to be in the third rank and the combination of Black seed oil + peppermint oil shows the highest debonding force. Conclusion: Despite the limitation of the present study result, an assumption has been drawn from the results obtained that (1) the 5- minutes of black seed or peppermint volatile oils application can be considered the best debonding agent compared to the other volatile oils; (2) the clove oil can be used after de-bonding to facilitate the final cleansing-up of enamel surface. To confirm the latter assumption, further investigations are needed.
Green marketing strategies for sustainable business growth

Environment friendly, so called green marketing has become a discussed subject and companies are constantly trying to find the best ways to reach the customers with their green message. Customers are becoming more demanding and they have started to pay more attention to the environment. The aim of this study is to find out how strategic issues in green marketing are addressed by Companies. Green marketing incorporates a variety of activities, including modifications to products, changes to the production and distribution processes, packaging, and modifications to marketing communications. In this paper, the authors have tried to explain the need and importance of Green Marketing and strategies for Green Marketing. They have also tried to explain some strategies to avoid Green Marketing Myopia. At last some Green Marketing practices have been shared to convince the readers that, Green Marketing is not only possible but also it is sustainable as well as profitable from various quarters.
Finding Hispanic Serving Institutions (HSIs) for STEM Education Best Practices: When a Picture Is Worth a Thousand Words

ABSTRACT The present study illustrates how select data can be organized to guide researchers to HSIs proficient at graduating Hispanics with STEM bachelor’s degrees to investigate best practices that less proficient HSIs can adopt for program improvement. The Integrated Postsecondary Education Data System (IPEDS) from the National Center for Education Statistics (NCES) was the data source. The primary analytic consisted of the scatterplot, supplemented by Pearson correlation r and regression analysis. While the findings failed to support the Hispanic undergraduate Pell rate as an explanatory variable for Hispanic STEM degree production capacity as the response variable, in a new light, the findings were an ideal model for initiating best practices research. Guidelines on initiating a “thousand word” discourse on best practices among HSI stakeholders, common defining moments one should anticipate at site visits, as well as the limitations and assumptions of the approach are presented. Based on the data, if low performing HSIs met the minimum benchmark level identified, the model predicted an increase of 17,392 or 50.7% additional Hispanics with STEM degrees for the US academic, technical, and professional workforce.
Targeting CDK4/6 for Anticancer Therapy

Cyclin-dependent kinase 4/6 (CDK4/6) are key regulators of the cell cycle and are deemed as critical therapeutic targets of multiple cancers. Various approaches have been applied to silence CDK4/6 at different levels, i.e., CRISPR to knock out at the DNA level, siRNA to inhibit translation, and drugs that target the protein of interest. Here we summarize the current status in this field, highlighting the mechanisms of small molecular inhibitors treatment and drug resistance. We describe approaches to combat drug resistance, including combination therapy and PROTACs drugs that degrade the kinases. Finally, critical issues and perspectives in the field are outlined.