Miracle-dz/UniFAR-FTUs huggingface dataset:
Cyprinus carpio Skeleton Byproduct as a Source of Collagen for Gelatin Preparation

Byproducts obtained from fish processing account for up to 70% of their live weight and represent a large amount of unused raw materials rich in proteins, fats, minerals, and vitamins. Recently, the management of the use of predominantly cold-water fish byproducts has become a priority for many processing companies. This paper describes the biotechnological processing of byproducts of warm-water Cyprinus carpio skeletons into gelatins. A Taguchi experimental design with two process factors (HCl concentration during demineralization of the starting material and the amount of enzyme during enzyme conditioning of the collagen) examined at three levels (0.5, 1.0 and 2.0 wt%; 0.0, 0.1 and 0.2 wt% respectively) was used to optimize the processing of fish tissue into gelatin. Depending on the preparation conditions, four gelatin fractions were prepared by multi-stage extraction from the starting material with a total yield of 18.7–55.7%. Extensive characterization of the gel-forming and surface properties of the prepared gelatins was performed. Gelatins belong to the group of zero–low-medium Bloom value (0–170 Bloom) and low–medium viscosity (1.1–4.9 mPa·s) gelatins and are suitable for some food, pharmaceutical, and cosmetic applications. During processing, the pigment can be isolated; the remaining solid product can then be used in agriculture, and H3PO4Ca can be precipitated from the liquid byproduct after demineralization. The carp byproduct processing technology is environmentally friendly and meets the requirements of zero-waste technology.
DIGITAL TECHNOLOGIES IN ECONOMICS AND MANAGEMENT AS A STRATEGIC VECTOR OF KAZAKHSTAN’S DEVELOPMENT IN THE CONTEXT OF THE EAEU DIGITAL AGENDA

The modern economic system based on rapidly developing digital technologies enhances global competition by introducing them on a large scale as an innovative product in various sectors of the economy of the EAEU countries. Digital transformation of the Kazakh economy as a strategic vector of its development in order to determine an effective mechanism for managing digital technologies in the context of Eurasian integration should ensure further economic growth and competitiveness of the country in the EAEU market. The main tools for managing the development of the digital economy are the effectiveness of the implementation of the State Program «Digital Kazakhstan» and the Resolution «On the main directions for implementing the digital agenda of the EAEU until 2025», the effectiveness of which is based on the creation of digital platforms as a mechanism for managing the digital economy. Managing the development of the digital economy is of quite serious interest, both in theoretical and practical terms. Therefore, the study is aimed at determining the digital advantages and digital maturity of the EAEU countries, taking into account the experience of leading countries in managing the transfer of digital technologies. This is important in the economy of each EAEU member state. Especially the approaches used by countries with a developed digital structure can be adopted by the countries of the Eurasian community, which have leadership aspirations for the development of digital technologies. The article presents a scientifically based model of an integrated information and communication system for managing the transfer of digital technologies that contribute to strategic decision-making and form the digital maturity of the economies of the EAEU countries. The originality of this conceptual study lies in its contribution to deepening the understanding of the process of joint creation of management institutions for digital technology transfer in the context of the EAEU agenda.
Effects of Particle Shape on the Shear Wave Velocity and Shear Modulus of 3D Printed Sand Analogs

Isolating the effects of individual particle properties (e.g. shape, size, min-eralogy, surface roughness) on the mechanical behavior of naturally occurring coarse-grained soils is a signiﬁcant challenge in experimental studies. This challenge can be addressed by recent advances in 3D printing technology which enable generation of ar-tiﬁcial sand-sized particles with independent control over particle size and shape. In this study, bender element tests are conducted to examine the isolated effects of particle shape on the shear wave velocity and shear modulus of 3D printed sand analogs. The experimental results show that the shear wave velocity and shear modulus of the 3D printed sand specimens exhibit a relationship with mean effective stress that is in agreement to that reported for natural sands. The specimens composed of 3D printed sands with greater particle roundness and sphericity exhibit greater shear wave velocity and shear modulus for a given void ratio, relative density, and mean effective stress. The changes in shear wave velocity can be captured in terms of differences in individual particle shape parameters such as roundness and sphericity as well as combined particle shape parameters such as regularity. Regression analysis is used to develop relationships between shear wave velocity and particle shape parameters and void ratio, which are shown to be in agreement with previously-published relationships and to reliably predict the shear wave velocity of natural sands. The results presented herein highlight the usefulness of testing 3D printed soils to identify functional trends and dependencies between soil response parameters and intrinsic properties. However, this requires veri-ﬁcation of the results against published trends and assessment of the possible effects of the differences in constituent material between the 3D printed and the natural soils.
INTERVENCIÓN COGNITIVO-CONDUCTUAL EN PACIENTES ASISTENTES A PSICOTERAPIA

Uno de los principales motivos de consulta en terapia psicológica es el presentar síntomas de ansiedad y depresión, ocasionando afectaciones a nivel cognitivo, físico y emocional.Objetivo: Valorar la eficacia de un tratamiento psicológico cognitivoconductual, en la disminución de la sintomatología de ansiedad y depresión, así como el aumento de los niveles de autoestima, satisfacción con la vida y relaciones intrafamiliares. Método: Se utilizó una muestra de dieciséis pacientes que se encontraban en tratamiento activo, atendidos en una clínica de psicología en modalidad ambulatoria. El diseño de intervención fue de un grupo, muestreado por conveniencia, aplicando pruebas antes y posterior al tratamiento. Para lamedición de las variables, se utilizaron las pruebas BAI (Inventario de ansiedad de Beck), BDI-II (Inventario de depresión de Beck-2), escala de autoestima de Rosenberg, escala de satisfacción con la vida y el inventario de evaluación de las relaciones intrafamiliares.Resultados: Los pacientes mostraron diferencias estadísticamente significativas en todas las variables a intervenir: ansiedad (z = 3.51; p = .000), depresión (z = 3.51; p = .000), autoestima (z = 3.51; p = .000), satisfacción con la vida (z = 3.18; p = .001), expresión familiar (z = 3.10;p = .002), unión familiar (z = 2.60; p = .009), y dificultades familiares (z =2.44; p = .015). Discusión y conclusiones: La terapia cognitiva conductual demostró eficacia en la muestra estudiada.
Animal-based entertainment industries, animal death and Social Licence to Operate (SLO): an analysis of ‘The Final Race’ and the 2019 Melbourne Cup

ABSTRACT Animal-based entertainment industries, predicated on asymmetrical human-animal relations, often operate legally but face growing opposition, focused particularly on animal death. In 2019, the documentary ‘The Final Race’ screened about two weeks before Australia’s most famous thoroughbred horse race, the Melbourne Cup, and exposed the secretive slaughter of unwanted racehorses in the ‘deep backstage’. This article highlights the importance of animals being made killable and what happens when animals supposedly being cared for are killed. Temporal and spatial boundary construction and movement are examined. Building on critical approaches to Social Licence to Operate (SLO), the article presents evidence that due mainly to animal death, social identification with horse racing is declining and social identification with resistance is rising, yet some pushback is occurring. This includes acknowledgement of past failings, presenting a united industry voice and slowly shifting boundaries to construct some horses as killable.
The Systematic Literature Review of Privacy-Preserving Solutions in Smart Healthcare Environment

The rapid development of the Internet of Medical Things (IoMT) technology has resulted in various advances in the smart healthcare field; it improves healthcare systems to offer more complicated real-time services and provides an efficient patient motioning system. However, despite the brilliant side of IoMT, several concerns continue to undercut its adoption. In fact, collecting, transmitting, storing, and using data in IoMT applications raises issues regarding privacy and data protection, especially with the multitude of stakeholders involved during the whole data life cycle. Motivated from these facts, this article is devoted to perform a Systematic Literature Review (SLR) of privacy-preserving solutions used in the smart healthcare ecosystem. The recent research papers disseminated between 2017 and 2021 are selected from multiple databases and a standardized SLR method is conducted. A total of 100 papers were reviewed and a critical analysis was conducted on the selected papers. Moreover, this review study attempts to highlight the limitation of the current approaches and aims to find possible solutions to them. Thus, a detailed analysis was carried out on the selected papers in terms of the privacy techniques they deployed, the data life cycle phase they addressed, the stakeholders needs they met, and the privacy principles they covered according to privacy laws and regulations. Finally, we summarize our results showing privacy-preserving trends and identifying recommendations to involve privacy principles coverage in smart healthcare applications.
Peptide Mediated Adhesion to Beta-Lactam Ring of Equine Mesenchymal Stem Cells: A Pilot Study

Simple Summary In recent years, stem cell therapy has emerged as a promising potential treatment for chronic wounds in both human and veterinary medicine. Particularly, mesenchymal stem cells (MSCs) may be an attractive therapeutic tool for regenerative medicine and tissue engineering because these cells play a critical role in wound repair and tissue regeneration due to their immunosuppressive properties and multipotency. The use of biomaterials with integrin agonists could promote cell adhesion increasing tissue repair processes. This pilot study focuses on the adhesion ability of equine adult (adipose tissue) and fetal adnexa (Wharton’s jelly) derived MSCs mediated by GM18, an α4β1 integrin agonist, alone and combined with a biodegradable polymeric scaffold. Results show that a 24 h exposition to soluble GM18 affects equine MSCs adhesion ability with a donor-related variability and might suggest that WJ-MSCs more easily adhere to poly L-lactic acid (PLLA) nanofibers combined with GM18. These preliminary results need to be confirmed by further studies on the interactions between the different types of equine MSCs and GM18 incorporated PLLA scaffolds before drawing definitive conclusions on which cells and scaffolds could be successfully used for the treatment of decubitus ulcers. Abstract Regenerative medicine applied to skin lesions is a field in constant improvement. The use of biomaterials with integrin agonists could promote cell adhesion increasing tissue repair processes. The aim of this pilot study was to analyze the effect of an α4β1 integrin agonist on cell adhesion of equine adipose tissue (AT) and Wharton’s jelly (WJ) derived MSCs and to investigate their adhesion ability to GM18 incorporated poly L-lactic acid (PLLA) scaffolds. Adhesion assays were performed after culturing AT- and WJ-MSCs with GM18 coating or soluble GM18. Cell adhesion on GM18 containing PLLA scaffolds after 20 min co-incubation was assessed by HCS. Soluble GM18 affects the adhesion of equine AT- and WJ-MSCs, even if its effect is variable between donors. Adhesion to PLLA scaffolds containing GM18 is not significantly influenced by GM18 for AT-MSCs after 20 min or 24 h of culture and for WJ-MSCs after 20 min, but increased cell adhesion by 15% GM18 after 24 h. In conclusion, the α4β1 integrin agonist GM18 affects equine AT- and WJ-MSCs adhesion ability with a donor-related variability. These preliminary results represent a first step in the study of equine MSCs adhesion to PLLA scaffolds containing GM18, suggesting that WJ-MSCs might be more suitable than AT-MSCs. However, the results need to be confirmed by increasing the number of samples before drawing definite conclusions.
Effects of feeding Saccharomyces cerevisiae fermentation products on the health and growth performance of Holstein dairy calves

Graphical Abstract Summary: The goal of this study was to determine the effects of feeding Saccharomyces cerevisiae fermentation products (SCFP) on the health and performance of dairy calves. Calves either received SCFP in both their milk replacer and solid feeds or they did not receive SCFP (CON). To evaluate health and performance, serum total protein (STP) was measured at the start of the study; body weight (BW), body condition score (BCS), hip width (HW), and hip height (HH) were measured biweekly; average daily gain (ADG) and feed efficiency (FE) were calculated pre- and postweaning; and intake, medical treatments, respiratory scores, and fecal scores were recorded daily. We determined that feeding SCFP to calves improved both health and performance as observed by increased postweaning ADG and FE, as well as reduced respiratory treatments.
Choice of Resistance Used in an Exercise: Simple to Complex Interactions

ABSTRACT The choice of the resistance used in a workout and its sequence in a training program is a crucial decision for program design. Although the choice in many ways looks simplistic, its interactions with other factors make it a bit more complex when designing a training program. Basic scientific principles help to give context for many aspects of such decisions. Interactions with other acute program variables will also be crucial in how that resistance load in an exercise is manifested in a workout stimulus. Understanding training program sequences using periodization models also affect how one applies the choice of resistances over time. Finally, age and training experience will influence resistance load progressions. Having a handle on these fundamental factors will help give the strength and conditioning professional better insights into the choices made in the resistance used in an exercise.
An Efficient Swift Routing Model with Node Trust Identity Factor (SRM-NTIF) to Perform Secure Data Transmission Among IoT Gadgets

According to a United Nations survey, the number of users using the internet has increased to 3 billion in recent years. The Auto-ID Center is a research organisation that coined the word "Internet of Things" (IoT) a decade ago, describing how it utilises wired or wireless networking technologies to create a channel of communication among technologies and networks available over the Internet. Despite the fact that a swing of routing protocols has been proposed in the literature, safe and energy-efficient routing protocol is still a work in progress. Many routing protocols expressly designed for resource limited wireless devices take the same approach and have nearly achieved their full improvements. The Internet of Things (IoT) has recently gained prominence as a result of the increasing number of connected devices being used in everyday human life with network lifetime constraints. Routing expertise is essential for establishing communication between nodes. A node should be capable of self-learning, self-configuring, and self-managing by gathering local knowledge and sharing it with its neighbours. The degree of trust determines the degree of cooperation between scattered mobile nodes. The term "trust" refers to a level of assurance based on node behavior. To ensure secure and proper data transmission in IoT network, the trust level of the nodes is calculated based on node behaviour. Because of the unexpected changes in the network structure, the complex existence of IoT network, and the underived prior trust relationship between the nodes, trust computation in IoT network is a difficult task. All IoT nodes willing to engage in data transmission are given a Digital Unique Identifier (DUI), and the proposed model must define their trust identity factors. Using the DUI, the proposed Swift Routing Model with Node Trust Identity Factor (SRM-NTIF) model, node authentication is performed to verify natural and malicious nodes in the network. The proposed model is compared with the traditional methods and the results show that the proposed model performance is better in security and trust levels.
An Overview of Emotion in Artificial Intelligence

The field of artificial intelligence (AI) has gained immense traction over the past decade, producing increasingly successful applications as research strives to understand and exploit neural processing specifics. Nonetheless emotion, despite its demonstrated significance to reinforcement, social integration, and general development, remains a largely stigmatized and consequently disregarded topic by most engineers and computer scientists. In this article, we endorse emotion’s value for the advancement of artificial cognitive processing, as well as explore real-world use cases of emotion-augmented AI. A schematization is provided on the psychological-neurophysiologic basics of emotion in order to bridge the interdisciplinary gap preventing emulation and integration in AI methodology, as well as exploitation by current systems. In addition, we overview three major subdomains of AI greatly benefiting from emotion, and produce a systematic survey of meaningful yet recent contributions to each area. To conclude, we address crucial challenges and promising research paths for the future of emotion in AI with the hope that more researchers will develop an interest for the topic and find it easier to develop their own contributions.
Flexible Versus Rigid Reaming Systems for Independent Femoral Tunnel Reaming During ACL Reconstruction: Minimum 2-Year Clinical Outcomes

Background: Radiographic and cadaveric studies have suggested that anatomic anterior cruciate ligament reconstruction (ACLR) femoral tunnel drilling with the use of a flexible reaming system through an anteromedial portal (AM-FR) may result in a different graft and femoral tunnel position compared with using a rigid reamer through an accessory anteromedial portal with hyperflexion (AAM-RR). No prior studies have directly compared clinical outcomes between the use of these 2 techniques for femoral tunnel creation during ACLR. Purpose: To compare revision rates at a minimum of 2 years postoperatively for patients who underwent ACLR with AM-FR versus AAM-RR. The secondary objectives were to compare functional testing and patient-reported outcomes between the cohorts. Study Design: Cohort study; Level of evidence, 3. Methods: Included were consecutive patients at a single academic institution between 2013 and 2018 who underwent primary ACLR without additional ligamentous reconstruction. Patients were separated into 2 groups based on the type of anatomic femoral tunnel drilling: AM-FR or AAM-RR. Graft failure, determined by revision ACLR, was assessed with a minimum 2 years of postoperative follow-up. The authors also compared patient-reported outcome scores (International Knee Documentation Committee [IKDC] and Knee injury and Osteoarthritis Outcome Score [KOOS]) and functional performance testing performed at 6 months postoperatively. Results: A total of 284 (AAM-RR, 232; AM-FR, 52) patients were included. The mean follow-up time was 3.7 ± 1.5 years, with a minimum 2-year follow-up rate of 90%. There was no significant difference in the rate of revision ACLR between the AAM-RR and AM-FR groups (10.8% vs 9.6%, respectively; P = .806). At 6 months postoperatively, there were no significant between-group differences in peak knee extension strength, peak knee flexion strength, limb symmetry indices, or hop testing, as well as no significant differences in IKDC (AAM-RR, 81.1; AM-FR, 78.9; P = .269) or KOOS (AAM-RR, 89.0; AM-FR, 86.7; P = .104). Conclusion: In this limited study, independent femoral tunnel drilling for ACLR using rigid or flexible reaming systems resulted in comparable rates of revision ACLR at a minimum of 2 years postoperatively, with no significant differences in strength assessments or patient-reported outcomes at 6 months postoperatively.
Enhancing Cytotoxicity of Tamoxifen Using Geranium Oil

Aromatherapy and plant-based essential oils are widely used as complementary and alternative therapies for various symptoms, including anxiety, mild mood disorders, and cancer-related pain. In a previous study, we developed an in vitro assay using immortalized hypothalamic neuronal cells (GT1-7 cells). In this study, we used this assay to investigate the effects of Geranium oil on the cytotoxicity of the oestrogen receptor (ER) antagonist: tamoxifen (TMX). The results showed that Geranium oil augmented TMX-induced cell death in a dose-dependent manner without directly reducing the viability of GT1-7 cells. Cotreatment with Geranium oil and ER agonist β-estradiol (E2) attenuated the inhibition of GT1-7 cell growth. Moreover, Geranium oil and geraniol, a major constituent of Geranium oil, showed weak agonist activity on ERα and ERβ with geraniol augmenting TMX-induced cell death similar to that observed in Geranium oil. Both compounds impair E2 activity. These data indicate that geraniol is an essential constituent of Geranium oil.
Productivity Improvement of a Manual Assembly Line

The current project addresses the productivity improvement of a manual assembly line by making use of operations analysis in the framework of Lean production. A methodology is proposed that helps to improve the productivity of any production process. The methodology consists of selecting a product or product family to be studied followed by current process study. Once the existing process is documented, all the assembly tasks involved must be timed using time study techniques. Operations analysis enables the reduction of non-productive tasks and results in a set of standardized work elements along with the set of standard procedures for performing the operations. Assembly line balancing along with the associated operations analysis assists in constructing or re-configuring an assembly system, which is the key step in improving the overall performance of an assembly line. Following this approach, two manual assembly line configurations (single stage parallel line and five-stage serial line) are constructed for a case study. The results show that by changing over to the single stage assembly line configuration the operator productivity is doubled when compared to the existing assembly method.
Involvement of IL-33 in the Pathophysiology of Systemic Lupus Erythematosus: Review

IL-33 is a newly discovered cytokine displaying pleiotropic localizations and functions. More specifically, it also functions as an alarmin, following its release from cells undergoing cell death or necrosis, to alert the innate immune system. The role of IL-33 has been underlined in several inflammatory and autoimmune diseases including systemic lupus erythematosus (SLE). The expressions of IL-33 as well as its receptor, ST2, are significantly upregulated in SLE patients and in patients with lupus nephritis. This review discusses the involvement of IL-33 in the pathology of SLE.