Miracle-dz/UniFAR-FTUs huggingface dataset:
PTHR1 Genetic Polymorphisms Are Associated with Osteoporosis among Postmenopausal Arab Women

The parathyroid hormone 1 receptor (PTHR1) plays a crucial role in calcium homeostasis and bone metabolism. However, its genetic role in regulating bone turnover markers (BTMs) in postmenopausal osteoporosis (PMO) remains unclear. Herein, we explored parathyroid hormone (PTH) and PTHR gene variant susceptibility to osteoporosis and their association with various circulating BTM and inflammatory markers in postmenopausal women of Arab ethnicity. In total, 600 postmenopausal Arab women (300-PMO and 300-control) were genotyped for selected SNPs in PTH (rs1459015, rs307253, rs6054, rs307247, rs10500783 and rs10500784), PTHR1 (rs6442037, rs1138518, and rs724449 SNPs) and PTHR2 (rs9288393, rs10497900, and rs897083). Anthropometrics, BTMs, and inflammatory markers were measured. Bone mineral density (BMD) was measured at the lumbar spine L1–L4 and the femoral neck using dual-energy X-ray absorptiometry (DXA). PTHR1 rs1138518 genotype C/T was found to be a significant risk factor for PMO (OR = 1.49, 95% CI 1.0-2.1, P = 0.03). The genotypes C/T and T/T of PTHR1 rs1138518 were associated with 25-hydroxy-vitamin D (25(OH)D) regulation. In the PMO group, carriers of the C/T genotype had significantly lower 25(OH)D levels than carriers of the same genotypes in the control group (59.9 (36.7-92.4) nmol/l and 66.4 (43.5-87.8) nmol/l, respectively; P = 0.048]. Our study concludes that the PTHR1 rs1138518 genotype could be a potential risk factor for osteoporosis and 25(OH)D regulation in Arab women with PMO.
DEGRADATION OF REACTIVE DYES USING IMMOBILIZED PEROXIDASE PURIFIED FROM NIGELLA SATIVA

The present study was aimed to exploit the free and immobilized peroxidase from Nigella sativa seeds to degradation of textile dyes polluting the environment and water. The optimum conditions for extracting the enzyme from the Nigella seeds were determined and the highest specific activity of the enzyme was obtained 1750 units / mg protein when extracting the enzyme from the ground seeds at a ratio of 1:20 (w: v) with sodium acetate buffer at 0.2 M and pH 5.0 for 15 minutes. The enzyme was purified using two steps including the concentration by sucrose and gel filtration by using Sephadex G-150. The results shown an increase in final purification folds 2.8 time with an enzyme yield of 35%. The immobilization of peroxidase were done by entrapment method using Ca- alginate and the immobilization ratio was reached to 49%. The removal efficiency of dyes by crude enzyme (free, immobilized) and partial purified peroxidase were studied with textile dyes such as yellow, red, black and blue dyes at optimum conditions pH 5, temperature 37oC after 3 hr. Maximum removal efficiency of dyes observed with crude peroxidase and reached (76.9, 88.7, 91 and 88) % respectively. These results were close to the efficiency of the purified enzyme in removing the four dyes, while the efficiency of the crude immobilized enzyme in removing the dyes was about (70, 81, 72 and 56.4)%, respectively.
Analysis of KRAS Mutation Status Prediction Model for Colorectal Cancer Based on Medical Imaging

This study retrospectively included some patients with colorectal cancer diagnosed by histopathology, to explore the feasibility of CT medical image texture analysis in predicting KRAS gene mutations in patients with colorectal cancer. Before any surgical procedure, all patients received an enhanced CT scan of the abdomen and pelvis, as well as genetic testing. To define patient groups, divide all patients into test and validation sets based on the order of patient enrollment. A radiologist took a look at the plain axial CT image of the tumor, as well as the portal vein CT image, at the corresponding level. The physician points the computer's cursor to the relevant area in the image, and TexRAD software programs together texture parameters based on various spatial scale factors, also known as total mean, total variance, statistical entropy, overall total average, mean total, positive mean, skewness value, kurtosis value, and general skewness. Using the same method again two weeks later, the observer and another physician measured the image of each patient again to see if the method was consistent between observers. With regard to clinical information, the KRAS gene mutation group and the wild group of participants in the test set and validation set each had values for the texture parameter. In a study of patients with colorectal cancer, the results demonstrated that CT texture parameters were correlated with the presence of the KRAS gene mutation. The best CT prediction model includes the values of the medium texture image's slope and the other CT fine texture image's value of entropy, the medium texture image's slope and kurtosis, and the medium texture image's mean and the other CT fine texture image's value of entropy. Regardless of the training set or the validation set, patients with and without KRAS gene mutations did not differ significantly in clinical characteristics. This method can be used to identify mutations in the KRAS gene in patients with colorectal cancer, making it practical to implement CT medical image texture analysis technology for that purpose.
Radiation from the transmission line with an acute bend

The transmission and radiation characteristics at an acute bend of a transmission line are investigated analytically. First, in consideration of the strong coupling to the adjacent conductor, the current distributions are decomposed into even and odd modes. Applying the traveling-wave mode method to these modes, it is shown that transmission characteristics of the line with an acute bend can be easily obtained. The abrupt variation of the voltage near the bend is noted. Next, the discontinuities of the traveling wave currents are regarded as radiating sources and the radiation field from the bend in the transmission line is derived by the summation of fields created by each of the discontinuities. It is found that there exist the electric field component radiating strongly in the directions of propagation of the current and another electric field component radiating strongly into the intermediate direction. Finally, by comparing with the former method and experimental results, the validity of the method is confirmed. >
Analysis of Simple Sequence Repeats (SSRs) Dynamics in Reticulitermes chinensis

: An abundance of potential inherent variation in SSR or microsatellite repeats has resulted in a valuable genetic marker in eukaryotes. We describe how SSRs in Reticulitermes chinensis castes are organized and abundant. Collectively we sequence 184,436 unigenes through the Trinity system, ranging from 201-43, 214 bp length from transcriptome data. Using MISA to find out SSRs in uni-genes and a total of 10740 SSRs loci were identified as di-, tri-, tetra-, penta-, and hexanucleotide. Among them, trinucleotide SSRs were the most abundant in R. chinensis genome 2702, followed by chromosome six (tri-) 1110. Pentanucleotide repeats were found at frequency 1 from each chromosome 8, 9 and 13, respectively. The frequency of AC/GT motif was (21.91%) reported, followed by others motif (16.6%), AAG/CTT (8.49%) and AGC/CTG (8.2%). The minimum motif types were AATG/ATTC (1.27%), followed by ACG/CGT (1.32%) and AAT/ATT (1.77%). Thes abundance and inherent variations in SSRs provide valuable information for taxonomics, phylogenetic, genome mapping, and population genetic research studies. SSR-based markers have high degrees of allelic variability and codominant legacy ( inheritance), and analytical ease.
High‐order finite‐element analysis of periodic absorbers

A high‐order vector finite‐element‐method (FEM) analysis of periodic absorbers is presented. By the virtue of the FEM, accurate modeling of complicated absorber structures is made possible. For a given accuracy, high‐order elements are used to reduce the number of unknowns and hence the computing time and memory consumption. The FEM is further combined with the asymptotic waveform evalaution (AWE) technique to produce fast‐frequency sweep. Both singly and doubly periodic absorbers are modeled and the accuracy of the method is demonstrated by comparisons with analytical solutions and published data. © 2003 Wiley Periodicals, Inc. Microwave Opt Technol Lett 37: 203–207, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10869
Extension to HiRLoc Algorithm for Localization Error Computation in Wireless Sensor Networks

Wireless sensor networks (WSNs) have gained importance in recent years as this support a large spectrum of applications such as automotive, health, military, environmental, home and office. Various algorithms have been proposed for making this technology more adaptive the existing algorithms address issues such as safety, security, power consumption, lifetime and localization. This paper presents an extension to HiRLoc algorithm and highlights its benefits. Extended HiRLoc significantly reduce the average localization error by suggesting a new method directional antenna based scheme.
Da abordagem do TQM (Total Quality Management) Ao GQM (Global Quality Management): a inserção e utilização da metodologia do projeto axiomático no desenvolvimento de modelos de gestão sistêmica da qualidade

In the past The the word quality has been in the past years synonymous of success or loss failure in many firms, and this situation is a results in of how these firms understanding the quality concepts. The development of these are responsible for a kind of quality that has simply last its original means concerning quality concepts has made that the quality abandons the simple way of products and processes control, in order to develop a systemic approach of quality management in the whole organization. The objective of this paper is to present a proposal of a quality systemic management model oriented by taking into account the firm's customer wants and attributes characteristics . In For the development of this work it is utilized the Axiomatic Design approach is used, which is established in function of axioms, corollaries and theorems, with the objective of to improve "good practices of design" in the construction of the quality systemic management model.
Manufacturing flexibility and advanced human resource management practices

This article analyses the connection between the use of advanced human resource management (HRM) practices, individually and as a system, with manufacturing flexibility. The results show a positive relationship between the implementation of advanced HRM practices and manufacturing flexibility. While most of the advanced HRM practices analysed show higher levels of implementation in flexible firms, no differences are observed in training efforts. Flexible firms are more prone to implement systems of advanced HRM practices.
Using Telemedicine to Assess and Manage Psychosis Among Outpatients with Neurodegenerative Disease

Abstract The presence of hallucinations and delusions in patients with neurodegenerative disease correlates negatively with function, cognition, quality of life, and survival. When these patients still have insight, the treatment of mild hallucinations may reduce the risk of progression to more severe symptoms, specifically hallucinations without insight or delusions. On October 22, 2020, a multidisciplinary consensus panel comprising United States-based experts in geriatric psychiatry, geriatric medicine, family medicine, movement disorders, and neuropsychology was convened remotely to discuss best practices for using telemedicine to evaluate, diagnose, and treat psychosis in patients with neurodegenerative diseases. This review reflects the opinions and recommendations discussed at this meeting. Despite drawbacks, telemedicine can offer several advantages over in-person care, particularly for older adults, and may be a unique opportunity for care of patients with neuropsychiatric symptoms. While telemedicine may not be suitable for all patients, it allows the involvement of specialists from multiple geographic locations and the extension of care to homebound individuals. Patients with neurodegenerative diseases who are likely to become homebound as the disease advances may benefit greatly from telemedicine as a standard of care. Healthcare provided via telemedicine should be nothing less than what would be offered to the patient in person. Telemedicine may present some difficulties, including technological issues and inherent constraints of remote care, but with proper planning many problems could be diminished. Technical issues associated with telemedicine are inevitable but may be partially offset by providing clear directions ahead of any tele-visit to ensure connectivity and access to the videoconferencing platform. Alternative procedures to communicate should be established in the eventuality of technological issues. Using these strategies, telemedicine can serve as a valuable complement to traditional in-person practices for the diagnosis and management of hallucinations and delusions associated with Parkinson’s disease psychosis or dementia-related psychosis.
Stunting does not impair physical fitness in Indonesian school children

Background Physical fitness is decreased in malnourished children and adults. Poor appearance and muscular flaccidity are among the first signs of malnutrition. Malnutrition is often associated with stunting. Objectives We test the hypotheses that stunted children of low social strata are physically less fit than children of high social strata. Sample We investigated 354 school girls and 369 school boys aged 5.83 to 13.83 (mean 9.54) years from three different social strata in Kupang (West-Timor, Indonesia) in 2020. Methods We measured height, weight, and elbow breadth, calculated standard deviation (SDS) of height and weight according to CDC references, and the Frame index as an indicator of long-term physical fitness, and we tested physical fitness in standing long jump and hand grip strength. Results Children of low social strata are physically fittest. They jump longer distances, and they have higher values in the Frame index. No association exists between height SDS and physical fitness, neither in respect to standing long jump, nor to hand grip strength. Conclusion Stunting does not impair physical fitness in Indonesian school children. Our results support the concept that SEPE (social-economic-political-emotional) factors are involved in the regulation of human growth.
Iterated Prisoner's Dilemma among mobile agents performing 2D random walk

When Iterated Prisoner's Dilemma takes place on a two-dimensional plane among mobile agents, the course of the game slightly differs from that one in a well-mixed population. In this paper we present a detailed derivation of the expected number of encounters required for Tit-for-tat strategy to get even with Always-Defect strategy in a Brownian-like population. It will be shown that in such an environment Tit-for-Tat can perform better than in a well-mixed population.
Optimum radar polarisation for target detection in sea clutter

The detection performance of a radar in sea clutter is dependent on a wide range of factors. For a noncoherent radar, using the envelope of the received signals for detection, the performance at a given range is principally dependent on the size of the clutter return, the signal-to-noise ratio and the amplitude statistics of the target and clutter. The paper describes the influence of vertical or horizontal polarisation on the detection performance. It is shown that the choice of polarisation can have a considerable effect on the performance and that the optimum choice is a complex function of the radar parameters, sea conditions and engagement geometry. For a given set of radar parameters and sea conditions it is shown that there is a critical height, below which the use of vertical polarisation will be optimum. (5 pages)
ViCAN: CO-ATTENTION NETWORK FOR VIETNAMESE VISUAL QUESTION ANSWERING

: In recent years, the task of Visual Question Answering (VQA) has evolved into a very attractive research field. Normally, this task requires a simultaneous understanding of both the visual content of the image and the textual content of the question. To produce an accurate answer, particularly in Vietnamese, we need to address the following four sub-problems effectively: (1) to efficiently extract visual representations of the image; (2) to develop fine-grained language processor for Vietnamese; (3) to implement ViCAN - a proper multimodal learning framework to focus on the complex interactions between image and text modalities; and (4) to provide prediction to consider the complex correlations between the image and the question to automatically obtain the answer. Not only handling all those tasks in this research, we also release a novel dataset for Vietnamese VQA of 590,083 question-answer pairs with 123,387 MS-COCO images. With an ensemble of our models, we achieve 68.76% of overall accuracy on our test set.
Regularization neural network for construction cost estimation

Estimation of the cost of a construction project is an important task in the management of construction projects. The quality of construction management depends on accurate estimation of the construction cost. Highway construction costs are very noisy and the noise is the result of many unpredictable factors. In this paper, a regularization neural network is formulated and a neural network architecture is presented for estimation of the cost of construction projects. The model is applied to estimate the cost of reinforced-concrete pavements as an example. The new computational model is based on a solid mathematical foundation making the cost estimation consistently more reliable and predictable. Further, the result of estimation from the regularization neural network depends only on the training examples. It does not depend on the architecture of the neural network, the learning parameters, and the number of iterations required for training the system. Moreover, the problem of noise in the data is taken into account in a rational manner.
Dopaminergic imaging in degenerative parkinsonisms, an established clinical diagnostic tool

Parkinson's disease (PD) and other neurodegenerative parkinsonisms are characterised by loss of striatal dopaminergic neurons. Dopamine functional deficits can be measured in vivo using positron emission tomography (PET) and single‐photon emission computed tomography (SPECT) ligands assessing either presynaptic (e.g. dopamine synthesis and storage, transporter density) or postsynaptic terminals (i.e. D2 receptors availability). Nuclear medicine imaging thus helps the clinician to separate degenerative forms of parkinsonism with other neurological conditions, e.g. essential tremor or drug‐induced parkinsonism. With the present study, we aimed at summarizing the current evidence about dopaminergic molecular imaging in the diagnostic evaluation of PD, atypical parkinsonian syndromes and dementia with Lewy bodies (DLB), as well as its potential to distinguish these conditions and to estimate disease progression. In fact, PET/SPECT methods are clinically validated and have been increasingly integrated into diagnostic guidelines (e.g. for PD and DLB). In addition, there is novel evidence on the classification properties of extrastriatal signal. Finally, dopamine imaging has an outstanding potential to detect neurodegeneration at the premotor stage, including REM‐sleep behavior disorder and olfactory loss. Therefore, inclusion of subjects at an early stage for clinical trials can largely benefit from a validated in vivo biomarker such as presynaptic dopamine pathways PET/SPECT assessment.
Saturated fatty acids intake is associated with muscle atrophy in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by joint inflammation, abnormal body composition, and an increased risk for sarcopenia. Muscle wasting in turn increases the risk of infection, morbidity, and premature mortality, but little is known of the relation between nutrient intake and sarcopenia in RA.
A hybrid encryption system with a Token device to avoid leak of information in corporate email

In this degree project, an implementation of both symmetric and asymmetric encryption algorithms for sending information through the SMTP protocol with a token device for authentication is proposed for an enterprise email application. The proposed system satisfies most security requirements such confidentiality, integrity, non repudiation and authentication. This software implementation combines the advantages of both symmetric-key algorithms and public-key algorithms that allow to have greater security and a fast implementation, therefore achieving better performance.
Native Bees are Important and Need Immediate Conservation Measures: A Review

: Field crops rely on managed and wild bee pollinators, raising concerns about world food security. In North America alone, 4,000 native bee species, provide over US$1.5 billion each year from bee pollinated crops. Wild entpollinatology constitute a great part of bio-diversity. In US, the nationwide annual production value of wild pollinators was estimated over $1.5 billion; the worth of wild bee pollination in insect pollinated crops would be much more. Pollinator declines could translate directly into reduced production in many crops, and that wild species contribute substan-tially to pollination of most crops. By pollinating just a handful of crops, wild bees contribute over $1.5 billion annually.In this article, after realizing the significance of wild bees, we highlight to manage wild native bee pollinators to act as co-actors to honey bees in enhancing the global crop production.
Second‐order efficient nonlinear filter stabilization for high Reynolds number flows

In this article, we develop a second‐order nonlinear filter based stabilization scheme for high Reynolds number flows. We prove the unconditional stability of the method, establish the second order consistency and discuss the dynamical tuning of the relaxation parameter. The scheme is then validated against experimental data for an isothermal turbulent flow in a Staggered Tube Bundle at Reynolds number of 18,000. Numerical results are found to be in an overall good qualitative and quantitative agreement with the benchmark results.
Influence of bone anisotropy in the case of implant-supported prostheses using a “All-On-Four” base

Implant-supported prostheses offer advantageous solutions for total edentulous mandibles. However, strong stresses can be expected in bones because of the implants presence. Finite element simulations are frenquently used to reproduce the behaviour of a mandibule supporting such prosthesis. It is necessary, in all cases, to define properly geometry, boundary conditions and material properties to guarantee results’ accuracy. Because of their high level of heterogeneity and anisotropy, bones behaviour is very difficult to model. The effect of bones anisotropy in the premolar region was analysed by O’Mahonny et al. (2001). In this work, we propose to study this effect in the mandible symphyseal region, for the case of an implantsupported prosthesis using an “All-On-Four” base. The traditional length of implant-supported prostheses is limited by the position of posterior implants that cannot interact with the mental nerve. Consequently, the number of restored teeth is generally limited to 10. To increase this number Krekmanov et al. (2000) studied the possibility to tilt posterior implants.