Miracle-dz/UniFAR-FTUs huggingface dataset:
School entrance examinations as a small-scale data source for health monitoring of children using obesity as an example

Background In the scope of the nationwide obligatory school entrance examinations (SEE), a standardised assessment of the preparedness for school of preschool children takes place in the federal states of Germany. For this purpose, height and weight of the children are determined. These data are available in aggregated form at county level, but are not yet being regularly compiled and processed at national level for use in policy and research. Methods In a pilot project, the indexing and merging of SEE data from 2015–2019 was tested in collaboration with six federal states. This was done using obesity prevalence at the time of the school entrance examination. In addition, prevalences were linked to small-scale indicators on settlement structure and sociodemographics from public databases, differences in obesity prevalence at county level were identified, and correlations to regional influencing factors were visualised. Results It was feasible to merge SEE data from the federal states with little effort. The majority of the selected indicators were freely available in public databases. In an interactive, easily comprehensible and user-friendly Tableau dashboard for visualising the SEE data, it can be seen that obesity prevalences differ significantly between counties that are similar in terms of settlement structure or sociodemographics. Conclusions Providing federal state SEE data and linking them to small-scale indicators enables region-based analyses and cross-state comparisons of similar counties and provides a data basis for continuous monitoring of the prevalence of obesity in early childhood.
Molecular correlates of vaccine-induced protection against typhoid fever

BACKGROUND Typhoid fever is caused by the Gram-negative bacterium Salmonella enterica serovar Typhi and poses a substantial public health burden worldwide. Vaccines have been developed based on the surface Vi-capsular polysaccharide of S. Typhi; these include a plain-polysaccharide-based vaccine, ViPS, and a glycoconjugate vaccine, ViTT. To understand immune responses to these vaccines and their vaccine-induced immunological protection, molecular signatures were analyzed using bioinformatic approaches. METHODS Bulk RNA-Seq data were generated from blood samples obtained from adult human volunteers enrolled in a vaccine trial, who were then challenged with S. Typhi in a controlled human infection model (CHIM). These data were used to conduct differential gene expression analyses, gene set and modular analyses, B cell repertoire analyses, and time-course analyses at various post-vaccination and post-challenge time points between participants receiving ViTT, ViPS, or a control meningococcal vaccine. RESULTS Transcriptomic responses revealed strong differential molecular signatures between the 2 typhoid vaccines, mostly driven by the upregulation in humoral immune signatures, including selective usage of immunoglobulin heavy chain variable region (IGHV) genes and more polarized clonal expansions. We describe several molecular correlates of protection against S. Typhi infection, including clusters of B cell receptor (BCR) clonotypes associated with protection, with known binders of Vi-polysaccharide among these. CONCLUSION The study reports a series of contemporary analyses that reveal the transcriptomic signatures after vaccination and infectious challenge, while identifying molecular correlates of protection that may inform future vaccine design and assessment. TRIAL REGISTRATION ClinicalTrials.gov NCT02324751.
The Effect of Coffee in the Prevention of Oral Mucositis Associated with Head and Neck Radiotherapy

Aim: This study investigates the effect of coffee on the management of oral mucositis associated with head and neck radiotherapy. Method: Twenty-nine patients who underwent radiotherapy for the first time due to head and neck cancer between March 2019 and February 2020 were included in the experimental study. One cup/day of Turkish coffee (6 mg) was given to the patients in the intervention group every day for 3 weeks from the first day of radiotherapy. Data monitoring of both groups was performed once a week for 3 weeks. Results: Most of the patients participating in the study were at local stage (65.2%), and 72.4% underwent head and neck radiotherapy with the diagnosis of nasopharynx and larynx cancer. Although the development rate of oral mucositis was lower in the intervention group, no statistically significant difference was determined (p > 0.05). In the repeated follow-up, the quality of life scores was found to be similar in both groups. Conclusion: We concluded that coffee application is not an effective approach in the prevention of oral mucositis associated with head and neck radiotherapy. Further studies with larger sample sizes are needed to determine the prophylactic effect of coffee in the management of oral mucositis.
Event-related Potentials Corresponding to Decision-making Under Uncertain Conditions

Background: Decision-making is essential to human functioning, and resolving uncertainty is an essential part of decision-making. Impaired decision-making is present in many pathological conditions, and identifying markers of decision-making under uncertainty will provide a measure of clinical impact in future studies of therapeutic intervention for impaired decision-making. Objective: To describe EEG event-related potentials (ERPs) correlating with decision-making under uncertain conditions when compared with certain conditions. Method: We used a novel card-matching task based on the Wisconsin Card Sorting Test to describe the neural correlates of uncertainty, as measured by EEG, in a group of 27 neurotypical individuals. We evaluated 500-ms intervals in the 2 seconds after card presentation to identify ERPs that are associated with maximal uncertainty compared with maximal certainty. Results: After correcting for multiple comparisons, we identified an ERP in the 500–1000-ms time frame (certain > uncertain, max amplitude 12.73 µV, latency 914 ms) in the left posterior inferior region of the scalp. We also found a P300-like ERP in the left frontal and parietal regions in the 0–500-ms time frame when the individuals received correct versus incorrect feedback (incorrect feedback > correct feedback, max amplitude 1.625 µV, latency 339 ms). Conclusion: We identified an ERP in the 500–1000-ms time frame (certain > uncertain) that may reflect the resolution of uncertainty, as well as a P300-like ERP when feedback is presented (incorrect feedback > correct feedback). These findings can be used in future studies to improve decision-making and resolve uncertainty on the described markers.
Green Chromatographic Methods and in Vitro Pharmacological Analysis of Varronia curassavica Leaf Derivatives

Varronia curassavica displays anti‐inflammatory, antiulcerogenic, and antioxidant activities. Herein, we employed new UHPLC –UV green chromatographic methods for the analysis of in vitro antioxidant and anti‐inflammatory activities of V. curassavica and its embryotoxicity in Zebrafish. Cordialin A, brickellin, and artemetin were purified from the ethanol (EtOH) extract of V. Curassavica leaves and identified using spectrometric techniques. In line with Green Analytical Chemistry principles, the proposed UHPLC methods involve the use of ethanol as organic modifier with low mobile phase consumption, and without sample pretreatment (OLE‐UHPLC‐UV). The application of the Agree and HPLC‐EAT tools for greenness assessment yielded this pattern: HPLC‐UV (reference)
Learning Curve and Clinical Outcomes of Ultrasonic Osteotome‐based En Bloc Laminectomy for Thoracic Ossification of the Ligamentum Flavum

Despite rapid advances in minimally invasive surgery, en bloc laminectomy remains the most common surgical approach for treating thoracic ossification of the ligamentum flavum (TOLF). However, the learning curve of this risky operation is rarely reported. Therefore, we aimed to describe and analyze the learning curve of ultrasonic osteotome‐based en bloc laminectomy for TOLF.
The Association Between Childhood Maltreatment and Body (dis)satisfaction in Adolescents and Young Adults from the General Population

ABSTRACT Adolescents with a history of childhood maltreatment are vulnerable to body dissatisfaction and associated psychopathology such as eating disorders. The aim of this study was to expand the understanding of the association between childhood maltreatment and body dissatisfaction in adolescents and young adults. In an epidemiological cohort study, N = 1,001 participants aged 14–21 years from Dresden, Germany, completed self-report measures on childhood maltreatment, body image, and self-esteem. Lifetime mental disorders were assessed in standardized clinical interviews. Data analyses included multiple regression and mediation analyses. More than one-third of the participants reported experiences of childhood maltreatment (37.4%), in which emotional neglect and abuse were the most frequent subtypes. Individuals with a history of childhood maltreatment showed significantly less satisfaction with their physical appearance than participants without such adverse experiences. In a single mediator model, self-esteem emerged as potential mediator in the association between child maltreatment and body (dis)satisfaction. Experiences of childhood maltreatment may be considered as risk factor for the development of body dissatisfaction in adolescents, and the role of potential mediator variables such as self-esteem warrants further prospective research.
Spinal Instability as a Prognostic Factor in Patients With Spinal Metastasis of Castration-resistant Prostate Cancer.

BACKGROUND/AIM To evaluate the Spinal Instability Neoplastic Score (SINS) for prediction of survival in patients with spinal column metastasis of castration-resistant prostate cancer (CRPC). PATIENTS AND METHODS A retrospective study of spinal instability was performed in patients with CRPC using SINS. Overall survival was evaluated starting from the time of SINS evaluation. The subjects were 42 patients with CRPC among 261 cases diagnosed with metastatic spinal tumors by radiologists, among 42,152 cases that underwent a body computed tomography scan at Kawasaki Medical School Hospital within 32 months from December 2013 to July 2016. RESULTS The median age was 78 (range=55-91 years), the median prostate-specific antigen (PSA) level at SINS evaluation was 42.1 (0.1-3,121.6) ng/ml, and 11 patients had visceral metastasis. The median periods from diagnosis of bone metastasis and development of CRPC to SINS evaluation were 17 (0-158) and 20 (0-149) months, respectively. The spine was stable in 32 cases (group S) and potentially unstable or unstable in 10 (24%) (group U). The median observation period was 17.5 (0-83) months and 36 patients died. The median survival period after SINS evaluation was longer in group S than that in group U (20 vs. 10 months, p=0.0221). In multivariate analysis, PSA level, visceral metastasis, and spinal instability were significant prognostic factors. The hazard ratio for patients in group U was 2.60 (95%CI=1.07-5.93, p=0.0345). CONCLUSION Spinal stability evaluated using SINS is a new prognostic factor for survival of patients with spinal metastasis of CRPC.
Structural and molecular cholinergic imaging markers of cognitive decline in Parkinson's disease.

Cognitive decline in Parkinson's disease is related to cholinergic system degeneration which can be assessed in vivo using structural MRI markers of basal forebrain volume and PET measures of cortical cholinergic activity. In the present study we aimed to examine the interrelation between basal forebrain degeneration and PET-measured depletion of cortical acetylcholinesterase activity as well as their relative contribution to cognitive impairment in Parkinson's disease. This cross-sectional study included 143 Parkinson's disease participants without dementia and 52 healthy control participants who underwent structural MRI, PET scanning with [11C]-methyl-4-piperidinyl propionate (PMP) as a measure of cortical acetylcholinesterase activity, and a detailed cognitive assessment. Based on the 5th percentile of the overall cortical PMP PET signal from the control group, people with Parkinson's disease were subdivided into a normo-cholinergic (N=94) and a hypo-cholinergic group (N=49). Volumes of functionally defined posterior and anterior basal forebrain sub-regions were extracted using an established automated MRI volumetry approach based on a stereotactic atlas of cholinergic basal forebrain nuclei. We used Bayesian t-tests to compare basal forebrain volumes between controls, and normo- and hypo-cholinergic Parkinson's participants after covarying out age, sex, and years of education. Associations between the two cholinergic imaging measures were assessed across all people with Parkinson's using Bayesian correlations and their respective relations with performance in different cognitive domains were assessed with Bayesian ANCOVAs. As a specificity analysis, hippocampal volume was added to the analysis. We found evidence for a reduction of posterior basal forebrain volume in the hypo-cholinergic compared to both normo-cholinergic Parkinson's (Bayes Factor against the null model (BF10)=8.2) and control participants (BF10=6.0), while for the anterior basal forebrain the evidence was inconclusive (BF10<3). In continuous association analyses, posterior basal forebrain volume was significantly associated with cortical PMP PET signal in a temporo-posterior distribution. The combined models for the prediction of cognitive scores showed that both cholinergic markers (posterior basal forebrain volume and cortical PMP PET signal) were independently related to multi-domain cognitive deficits, and were more important predictors for all cognitive scores, including memory scores, than hippocampal volume. We conclude that degeneration of the posterior basal forebrain in Parkinson's disease is accompanied by functional cortical changes in acetylcholinesterase activity and that both PET and MRI cholinergic imaging markers are independently associated with multi-domain cognitive deficits in Parkinson's disease without dementia. Comparatively, hippocampal atrophy only seems to have minimal involvement in the development of early cognitive impairment in Parkinson's disease.
A Rapid Systematic Review of Pharmacologic Sleep Promotion Modalities in the Intensive Care Unit

Background: The Society of Critical Care Medicine Clinical Practice Guidelines for Management of Pain, Agitation, Delirium, Immobility, and Sleep recommend protocolized non-pharmacologic sleep improvement. Pharmacologic interventions are frequently initiated to promote sleep but the evidence supporting these strategies remains controversial. Purpose: To systematically search and synthesize evidence evaluating pharmacologic sleep promotion modalities in critically ill adults. Methods: A rapid systematic review protocol was used to search Medline, Cochrane Library, and Embase for reports published through October 2022. We included randomized controlled trials (RCTs) and before-and-after cohort studies evaluating pharmacologic modalities intended to improve sleep in adult intensive care unit (ICU) patients. Sleep-related endpoints were the primary outcome of interest. Study and patient characteristics and relevant safety and non-sleep outcome data were also collected. The Cochrane Collaboration Risk of Bias or Risk of Bias in Non-Randomized Studies of Interventions were used to assess the risk of bias for all included studies. Results: Sixteen studies (75% RCTs) enrolling 2573 patients were included; 1207 patients were allocated to the pharmacologic sleep intervention. Most studies utilized dexmedetomidine (7/16; total n = 505 patients) or a melatonin agonist (6/16; total n = 592 patients). Only half of the studies incorporated a sleep promotion protocol as standard of care. Most (11/16, 68.8%) studies demonstrated a significant improvement in ≥1 sleep endpoint (n = 5 dexmedetomidine, n = 3 melatonin agonists, n = 2 propofol/benzodiazepines). Risk of bias was generally low for RCTs and moderate-severe for cohort studies. Conclusions: Dexmedetomidine and melatonin agonists are the most studied pharmacologic sleep promotion modalities, but current evidence does not support their routine administration in the ICU to improve sleep. Future RCTs evaluating pharmacologic modalities for ICU sleep should consider patients’ baseline and ICU risks for disrupted sleep, incorporate a non-pharmacologic sleep improvement protocol, and evaluate the effect of these medication interventions on circadian rhythm, physiologic sleep, patient-perceived sleep quality, and delirium.
Protective Effects of Fuziline on Dobutamine-Induced Heart Damage in Mice

Introduction Fuziline is one of the many antioxidants currently being tested to treat cardiac damage. In our study, histopathological and biochemical effects of fuziline were investigated in mice with dobutamine-induced heart damage in vitro. Methods Thirty-two adult male BALB/c mice, average weight of 18-20 g, were randomly divided into four groups - Group 1 (sham, n=8), Group 2 (control, dobutamine, n=8), Group 3 (treatment 1, dobutamine + fuziline, n=8), and Group 4 (treatment 2, fuziline, n=8). Biochemical parameters and total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values were measured. Interleukin 1 beta (IL-1β), NLR family, pyrin domain containing protein 3 (NLRP3), 8-hydroxy-deoxyguanosine (8-OHDG), gasdermin D (GSDMD), and galectin 3 (GAL-3) levels were analyzed by enzyme-linked immunosorbent assay method, and histopathological examination of heart tissues was performed. Results When dobutamine + fuziline and fuziline groups were compared, troponin-I (P<0.05), NLRP3 (P<0.001), GSDMD (P<0.001), 8-OHDG (P<0.001), IL-1β (P<0.001), and GAL-3 (P<0.05) were found to be statistically significant. TOS level was the highest in the dobutamine group (P<0.001) and TAS level was the highest in the fuziline group (P<0.001). OSI level was statistically significant between the groups (P<0.001). In histopathological examination, focal necrosis areas were smaller in the dobutamine + fuziline group than in the dobutamine group, and cardiac myocytes were better preserved. Conclusion Fuziline markedly reduced cardiac damage and pyroptosis in mice with dobutamine-induced heart damage by lowering the levels of GSDMD, 8-OHDG, IL-1β, and GAL-3. It also prevented necrosis of cardiac myocytes in histopathological evaluation.
A high‐selectivity dual‐polarization filtering antenna with metamaterial for 5G application

A high‐selectivity dual‐polarization filtering antenna with metamaterial is presented in this letter. The multilayer coupled radiation structure of the antenna determines a filtering function. With the metamaterial layer designed above the antenna, a sharp roll‐off rate at high pass band edge and a better out‐of‐band rejection occurs, thus a better high selective filtering characteristic can be achieved. Simulating and measuring the antenna, the impedance bandwidth (VSWR <2) of the antenna is from 3.25 GHz to 3.85 GHz; meanwhile, the maximum gain can reach 9dBi. The gain of antenna can quickly decrease 43dBi at the high pass band edge from 3.85 GHz to 4.05 GHz and the antenna has an out‐of‐band rejection level of 27dBi from 4.05 GHz to 5 GHz. The tested results verify our designs and the antenna could be a good candidate for the 5G anti‐interference wireless terminal communication system.
Impulse noise measurements of M16 rifles at Quantico Marine Base

This paper describes a study conducted at U.S. Marine Corps Base Quantico to determine firing range impulse noise levels and assess noise exposures. Measurements were performed with M16 rifles at an outdoor firing range using a 113-channel array of 6.35 and 3.18 mm microphones that spanned potential locations for both shooters and instructors. Data were acquired using 24-bit cards at a sampling rate of 204.8 kHz. Single weapon measurements were made with and without an occupied range, with a shooter and with a remotely triggered gun stand. In addition, measurements were made with multiple shooters to simulate exposures for a realistic range environment. Results are shown for the various range configurations as a function of angle and distance. Analyses include waveforms, spectra, and peak levels, as well as the 100 ms A-weighted equivalent levels required by military standard MIL-STD-1474E. [Sponsored by US Office of Naval Research. ]This paper describes a study conducted at U.S. Marine Corps Base Quantico to determine firing range impulse noise levels and assess noise exposures. Measurements were performed with M16 rifles at an outdoor firing range using a 113-channel array of 6.35 and 3.18 mm microphones that spanned potential locations for both shooters and instructors. Data were acquired using 24-bit cards at a sampling rate of 204.8 kHz. Single weapon measurements were made with and without an occupied range, with a shooter and with a remotely triggered gun stand. In addition, measurements were made with multiple shooters to simulate exposures for a realistic range environment. Results are shown for the various range configurations as a function of angle and distance. Analyses include waveforms, spectra, and peak levels, as well as the 100 ms A-weighted equivalent levels required by military standard MIL-STD-1474E. [Sponsored by US Office of Naval Research. ]
Leading-Edge Vortices: Mechanics and Modeling

The leading-edge vortex (LEV) is known to produce transient high lift in a wide variety of circumstances. The underlying physics of LEV formation, growth, and shedding are explored for a set of canonical wing motions including wing translation, rotation, and pitching. A review of the literature reveals that, while there are many similarities in the LEV physics of these motions, the resulting force histories can be dramatically different. In two-dimensional motions (translation and pitch), the LEV sheds soon after its formation; lift drops as the LEV moves away from the wing. Wing rotation, in contrast, incites a spanwise flow that, through Coriolis tilting, balances the streamwise vorticity fluxes to produce an LEV that remains attached to much of the wing and thus sustains high lift. The state of the art of vortex-based modeling to capture both the flow field and corresponding forces of these motions is reviewed, including closure conditions at the leading edge and approaches for data-driven strategies.
COMPACT BRANCH-LINE COUPLER WITH HARMONIC SUPPRESSION BASED ON A PLANAR SIMPLIFIED DUAL COMPOSITE RIGHT/LEFT-HANDED TRANSMISSION LINE STRUCTURE

In this paper, a planar simplified dual composite right/left-handed (SD-CRLH) transmission line (TL) structure is proposed and applied to the design of branch-line coupler. The SD-CRLH TL is obtained by a microstrip line with an open-ended stub in square spiral form. Since this structure has unusual phase shift characteristics with a transmission zero out of the passband, the branch-line coupler with the planar SD-CRLH TL can achieve both size reduction and harmonic suppression. Such a branch-line coupler operating at 0.915 GHz is investigated and fabricated. The equivalent circuit simulation, full-wave simulation and measurement results agree well with each other. From the results, it is shown that the area of the proposed branch line coupler is reduced by 74% compared to the conventional one while maintaining similar performance, and the second harmonic suppression can be lower than −45 dB.