Miracle-dz/UniFAR-FTUs huggingface dataset:
Critical Education Praxis of Critical Literacy Pragmatic Utilization of Theoretical Tensions

The purpose of this paper is to re-examine the foundation of critical literacy. I claim that critical literacy should be conceived as praxis rather than a unified theory. This is because the foundation of critical literacy includes diverse philosophical positions with some disagreements between them. When critical literacy is treated as a unified theory, such internal contradictions implode the theory. Instead, by conceiving it as praxis, even those theoretical tensions can be rendered generative for insatiable reading of the wor(l)d. To demonstrate this, I juxtapose Marxist/Freirean approach and Foucauldian approach to critical literacy. The former approach promotes solidarity among the oppressed by “naming” the wrongs of the world
Effect of pentaerythritol tetranitrate (PETN) on the development of fetal growth restriction in pregnancies with impaired uteroplacental perfusion at midgestation—a randomized trial

BACKGROUND: Fetal growth restriction is strongly associated with impaired placentation and abnormal uteroplacental blood ﬂow. Nitric oxide donors such as pentaerythritol tetranitrate are strong vasodilators and pro-tect the endothelium. Recently, we demonstrated in a randomized controlled pilot study a 38% relative risk reduction for the development of fetal growth restriction or perinatal death following administration of pentaerythritol tetranitrate to pregnant women at risk, identiﬁed by impaired uterine perfusion at midgestation. Results of this monocenter study prompted the hypothesis that pentaerythritol tetranitrate might have an effect in pregnancies with compromised placental function as a secondary prophylaxis. OBJECTIVE: This study aimed to test the hypothesis that the nitric oxide donor pentaerythritol tetranitrate reduces fetal growth restriction and perinatal death in pregnant women with impaired placental perfusion at midgestation in a multicenter
Ferroelastic phase transitions and anelastic dissipation in the LaAlO 3 -PrAlO 3 solid solution series

Resonant ultrasound spectroscopy has been used on single-crystal samples to observe pseudoproper ferroelastic softening across the $(\text{La},\text{Pr}){\text{AlO}}_{3}$ solid solution. It is suggested that softening is due to the presence of an intrinsic zone-center instability in addition to the small Jahn-Teller stabilization expected for ${\text{Pr}}^{3+}$. Softening increases as smaller ${\text{Pr}}^{3+}$ ions are substituted for larger ${\text{La}}^{3+}$ which is attributed to a simple size effect as well as the possibility of bilinear coupling of the intrinsic instability with the weak Jahn-Teller effect. Superattenuation is observed above 600 K for all samples, which is consistent with twin wall related dissipation behavior seen in other perovskites with octahedral tilting. Superattenuation is also observed in the low-temperature monoclinic phase, implying a high mobility also for the monoclinic twin walls.
Atmospheric turbulence visualization with wide-area motion-blur restoration

A new technique for visualizing the effects of turbulence in clear air and concurrent wide-area motion-blur image restoration is described. Time sequences of images of a scene are captured with an optical telescope covering a comparatively wide field of view. With short-exposure times, atmospheric distortion is frozen to provide a sequence of randomly warped images. Point-by-point registration results in x and y shift maps describing the warp for each image. These maps provide not only a striking visualization of the turbulence but also a means for dewarping each image prior to averaging to form a wide-area motion-blur-corrected result. It is believed that the technique will be of benefit in astronomy, atmospheric physics, and surveillance.
A Comparative Study of Synchronization and Circularization in Close Binaries

In this paper we examine a variety of topics dealing with synchronization and orbital circularization in detached close binaries. First, we calculate the unsteady tidally induced currents in a nonsynchronous binary component that has a large density gradient in its interior. Boundary-layer theory is used to confirm the order of magnitude of the spin-down time t sd that was obtained in our previous investigations. It is thus found that the hydrodynamical spin-down is a very efficient mechanism because the time t sd is proportional to the factor (d/R) 4.125 , where d/R is the distance ratio
NUCLEIExperiment Orientation Features of the 3 −−− State of the 14 C Nucleus at 6.73 MeV in the Reaction 13 С ( d, pγ ) 14 ( d, pγ ) 14 ( d, pγ ) 14 C

— The di ﬀ erential cross sections and p – γ angular-correlation functions were measured for the reactions 13 C ( d, p 3 γ 6 . 73 ) 14 C and 13 C ( d, p 1 γ 6 . 09 ) 14 C induced by deuterons accelerated to an energy of 15.3 MeV at the cyclotron of Skobeltsyn Institute of Nuclear Physics, Moscow State University. All even spin-tensor components of the density matrix were reconstructed for the 14 C nucleus in the 3 − state at 6.73 MeV, and various orientation features of this nuclear state were determined for the ﬁ rst time. These experimental results were compared with their counterparts calculated under the assumption of the neutron-stripping mechanism and on the basis of the compound-nucleus model.
The peaks of nonequilibrium UV radiation from a small impurity of iodide molecules at the front of shock waves (SWs) propagating in various inert gases

The direct simulation Monte Carlo (DSMC) method is used for modeling the problem on the shock wave front in the 0.7%I2–99.3%He mixture for a shock wave Mach number of 4.85. The choice of this system is due to the fact that intense radiation peaks have been observed experimentally precisely in such sys tems and it has been convincingly proven that this effect is induced by high energy collisions between I2 mol ecules. The results of simulation provide additional sound arguments in favor of the conclusion that the trans lational nonequilibrium state at the shock wave front in a light gas with a small admixture of heavy nonreact ing molecules may cause the experimentally observed nonequilibrium radiation peaks. DOI: 10.1134/S1063784213050071 GASES AND LIQUIDS
Dynamic Choices of Hyperbolic Consumers

Laboratory and field studies of time preference find that discount rates are much greater in the short-run than in the long-run. Hyperbolic discount functions capture this property. This paper solves the decision problem of a hyperbolic consumer who faces stochastic income and a borrowing constraint. The paper uses the bounded variation calculus to derive the Hyperbolic Euler Relation, a natural generalization of the standard Exponential Euler Relation. The Hyperbolic Euler Relation implies that consumers act as if they have endogenous rates of time preference that rise and fall with the future marginal propensity to consume (e.g., discount rates that endogenously range from 5% to 41% for the example discussed in the paper).
Variational principles for the spectral radius of functional operators

The spectral radius of a functional operator with positive coefficients generated by a set of maps (a dynamical system) is shown to be a logarithmically convex functional of the logarithms of the coefficients. This yields the following variational principle: the logarithm of the spectral radius is the Legendre transform of a convex functional defined on a set of vector-valued probability measures and depending only on the original dynamical system. A combinatorial construction of the functional by means of the random walk process corresponding to the dynamical system is presented in the subexponential case. Examples of the explicit calculation of the functional and the spectral radius are presented.
Chronic pain gene expression changes in the brain and relationships with clinical traits

Abstract Background Chronic pain is a common, poorly-understood condition. Genetic studies including genome wide association studies (GWAS) identify many relevant variants, which have yet to be translated into full understanding of chronic pain. Transcriptome wide association study using transcriptomic imputation (TI) methods such as S-PrediXcan can help bridge this genotype-phenotype gap. Methods We carried out TI using S-PrediXcan to identify genetically regulated gene expression (GREX) in thirteen brain tissues and whole blood associated with Multisite Chronic Pain (MCP). We then imputed GREX for over 31,000 Mount Sinai BioMe; participants and performed phenome-wide association study (PheWAS) to investigate clinical relationships in chronic pain associated gene expression changes. Results We identified 95 experiment-wide significant gene-tissue associations (p<7.97x10-7), including 35 unique genes, and an additional 134 gene-tissue associations reaching within-tissue significance, including 53 additional unique genes. Of 89 unique genes total, 59 were novel for MCP and 18 are established drug targets. Chronic pain GREX for 10 unique genes was significantly associated with cardiac dysrhythmia, metabolic syndrome, disc disorders/ dorsopathies, joint/ligament sprain, anemias, and neurological disorder phecodes. PheWAS analyses adjusting for mean painscore showed associations were not driven by mean painscore. Conclusions We carried out the largest TWAS of any chronic pain trait to date. Results highlight potential causal genes in chronic pain development, and tissue and direction of effect. Several gene results were also drug targets. PheWAS results showed significant association for phecodes including cardiac dysrhythmia and metabolic syndrome, indicating potential shared mechanisms.
Molecular & Translational Biology of the Blood-Based VeriStrat(R) Proteomic Test Used in Cancer Immunotherapy Treatment Guidance

INTRODUCTION: The blood-based VeriStrat(R) proteomic test (VS) predicts patient response to therapy based on the intensities of eight different features in a mass spectrum obtained from MALDI-TOF analysis of human serum/plasma specimens. An interim analysis of the INSIGHT clinical trial (NCT03289780) demonstrated that VS labels, VS Good and VS Poor, predict patients with non-small cell lung cancer (NSCLC) who are likely sensitive or resistant to immune checkpoint inhibitor (ICI) therapy [1]. While VS measures intensities of eight spectral features by matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry from patient serum/plasma samples, the individual proteoforms underlying these features have not been rigorously and comprehensively identified. OBJECTIVES: The objective of this study was to identify the proteoforms measured by VS. METHODS: Mass spectra for VS are acquired using a standard low-resolution MALDI-TOF procedure that generates broad, composite features. DeepMALDI [2] analysis of serum samples was used to resolve these features into finer peaks. Top-down proteomics analysis of human serum, combining reversed-phase fractionation and liquid chromatography - tandem mass spectrometry (LC-MS/MS), was then used to identify the key proteoform constituents of these peaks. RESULTS: It was determined that proteoforms of serum amyloid A1, serum amyloid A2, serum amyloid A4, C-reactive protein, and beta-2 microglobulin are primary constituents of the VS spectral features. CONCLUSION: Proteoforms of several proteins related to host immunity were identified as major constituents of these features. This information advances our understanding of how VS can predict patient response to therapy and opens the way for further translational studies.
Avidity sequencing of whole genomes from retinal degeneration pedigrees identifies causal variants

Whole genome sequencing has been an effective tool in the discovery of variants that cause rare disease. In this study, we determined the suitability of a novel avidity sequencing approach for rare disease applications. We built a sample to results workflow, combining the novel sequencing technology with standard library preparation kits, analysis workflows, and interpretation tools. We applied the workflow to ten pedigrees with inherited retinal degeneration (IRD) phenotype. Candidate variants of interest identified through whole genome sequencing were further evaluated using segregation analysis. Mutations in known IRD genes were detected in five of the ten cases. Genes with identified high confidence variants associated with retinal degeneration included PEX6, ABCA4, CERKL, MAK, and RDH12. Pending confirmatory clinical sequencing, we observed a 50% diagnostic yield, consistent with previously reported outcomes of IRD patient analysis. The study confirms that avidity sequencing is effective in detection of causal mutations when used for whole genome sequencing in rare disease applications.
Voltage-controlled hole spin injection in nonmagneticGaAs∕AlAsresonant tunneling structures

H. B. de Carvalho,1 Y. Galvao Gobato,2,* M. J. S. P. Brasil,1 V. Lopez-Richard,3 G. E. Marques,2 I. Camps,2 M. Henini,4 L. Eaves,4 and G. Hill5 1Grupo de Propriedades Opticas, Instituto de Fisica Gleb Wataghin, Universidade de Campinas, 13083-970 Campinas, SP, Brazil 2Departamento de Fisica, Universidade Federal de Sao Carlos, 13560-905 Sao Carlos, SP, Brazil 3Faculdade de Filosofia Ciencias e Letras de Ribeirao Preto, Departamento de Fisica e Matematica, Universidade de Sao Paulo, 14040-901 Ribeirao Preto, SP, Brazil 4School of Physics and Astronomy, University of Nottingham, NG7 2RD Nottingham, United Kingdom 5EPSRC National Centre for III-V Technologies, University of Sheffield, Mappin Street, Sheffield S1 3JD, United Kingdom Received 14 November 2005; revised manuscript received 19 January 2006; published 18 April 2006
Use of volatile anesthetics for sedation in the ICU during the COVID-19 pandemic: A national survey in France (VOL’ICU 2 study)

Background The COVID-19 pandemic has increased the number of patients in ICUs leading to a worldwide shortage of the intravenous sedative agents obligating physicians to find alternatives including inhaled sedation. Inhaled sedation in French ICU has been previously explored in 2019 (VOL’ICU study). This survey was designed to explore the use of inhaled sedation two years after our first survey and to evaluate how the COVID-19 pandemic has impacted the use of inhaled sedation. Methods We designed a national survey, contacting medical directors of French ICUs between June and October 2021. Over a 50-item questionnaire, the survey covered the characteristics of the ICU, data on inhaled sedation, and practical aspects of inhaled ICU sedation for both COVID-19 and non-COVID-19 patients. Answers were compared with the previous survey, VOL’ICU. Results Among the 405 ICUs contacted, 25% of the questionnaires were recorded. Most ICU directors (87%) knew about the use of inhaled ICU sedation and 63% of them have an inhaled sedation’s device in their unit. The COVID-19 pandemic increased the use of inhaled sedation in French ICUs. The main reasons said by the respondent were “need for additional sedative” (62%), “shortage of intravenous sedatives” (38%) and “involved in a clinical trial” (30%). The main reasons for not using inhaled ICU sedation were “device not available” (76%), “lack of familiarity” (60%) and “no training for the teams” (58%). More than 70% of respondents were overall satisfied with the use of inhaled sedation. Almost 80% of respondents stated that inhaled sedation was a seducing alternative to intravenous sedation for management of COVID-19 patients. Conclusion The use of inhaled sedation in ICU has increased fastly in the last 2 years, and is frequently associated with a good satisfaction among the users. Even if the COVID-19 pandemic could have impacted the widespread use of inhaled sedation, it represents an alternative to intravenous sedation for more and more physicians.
Targeted delivery of ursolic acid and oleanolic acid to lungs in the form of an inhaler for the management of tuberculosis: Pharmacokinetic and toxicity assessment

Introduction Ursolic acid (UA) and oleanolic acid (OA) are triterpenoids. They are used to treat numerous diseases, including tuberculosis. Combinations of these drugs provide new insight into the management of tuberculosis. The major obstacle is the effective delivery of these drugs to the lungs, which are mainly affected due to M. tuberculosis. A metered-dose inhaler (MDI) was developed to address this issue containing UA and OA, followed by in-vitro and in-vivo evaluation. Methods In the present study, MDI formulation was prepared by incorporating UA and OA at the dose level of 120 μg/ml in each actuation. In-vitro evaluation of this MDI formulation was performed to ensure its suitability to deliver UA and OA preciously. With prior approval of IAEC, a pharmacokinetic and acute inhalation toxicity study was conducted using MDI on Wistar rats. Results The pharmacokinetic study showed an increased biological half-life of UA (9.23±0.104 h) and OA (8.93±0.166 h) in combination therapy. In-vivo toxicity study demonstrated no adverse effects on body weight and vital organs in the treatment group compared with the control group. Histopathology examination of these essential organs showed no abnormalities. Mild alternation in the biochemical and hematological parameters was observed. However, these alterations did not affect the overall health of the animals. Conclusion The present study documents a detailed study for the safety and pharmacokinetics of UA and OA in-vivo for their advanced application in tuberculosis disease.
Effective connectivity of the amygdala during the consumption of erotic, sexual humor, and monetary rewards with a DCM-PEB approach

While a large body of research exists on the processing of monetary rewards, less is known about sexual reward processing. This study aimed to identify effective connectivity for the consumption of sexual (erotic and sexual humor) and non-sexual (monetary) rewards, using dynamic causal modeling and parametric empirical Bayes with subjective hedonic ratings included. Our results support the importance of the amygdala for sexual humor amusement, the nucleus accumbens (NAc) for monetary rewards, and the lateral orbitofrontal cortex (lOFC) for erotic pleasure. The amygdala, NAc, and lOFC are major dopaminergic targets with known roles in the reward circuitry. Appreciating sexual humor was associated with ventral tegmental area (VTA) to amygdala connectivity. Enjoying monetary gains was associated with VTA-to-NAc and amygdala-to-NAc connectivity. The mesolimbic dopamine system originates in the VTA and sends major projections to the amygdala and NAc. Specifically, sexual humor appreciation was associated with effective connectivity from the ventromedial prefrontal cortex (vmPFC) to the amygdala, suggesting that subjective pleasure triggers activation of the vmPFC which exerts an excitatory influence on the amygdala. Unexpectedly, processing pleasure from monetary gains was linked to VTA-to-vmPFC connectivity, rather than the expected vmPFC-to-NAc connectivity. Importantly, we identified core roles for the amygdala. Sexual humor appreciation was associated with VTA-to-amygdala and vmPFC-to-amygdala effective connectivity, while we found amygdala-to-lOFC connectivity for erotic pleasure and amygdala-to-NAc connectivity for pleasure from monetary gains. Our findings represent an important step in understanding how effective connectivity in the mesocorticolimbic-amygdala circuitry differs for processing the consumption of sexual and monetary rewards.
Thermal stability of nanoscale Ge metal-oxide-semiconductor capacitors with ZrO2 high-k gate dielectrics on Ge epitaxial layers

The authors report on the thermal stability of Ge metal-oxide-semiconductor (MOS) devices. Ge MOS capacitors with ZrO2 high-k gate dielectric and TaN metal gates were fabricated on Ge epitaxial films. Ge MOS capacitors exhibited a very low gate leakage current density of ∼1×10−6A∕cm2 with a capacitance equivalent thickness of 13A. The excellent electrical characteristics, however, degraded when Ge∕ZrO2 gate stacks were subsequently annealed at elevated temperatures that are potentially used for transistor fabrication. The thermal degradation was due primarily to the formation of interfacial Ge oxides. Ge oxidation temperature was identified using surface analysis and correlated with electrical characteristics.
Network anomaly detection based on ensemble learning

With the improvement of facility condition and network speed, the network traffic has also presented an exponential growth in recent years. However, a growing number of problems concerning cyber security have appeared. Anomaly network traffic detection can identify abnormal traffic from massive traffic. Accurate identification can reduce anomaly network traffic and protect user client. Our research is based on the traffic collected and processed by National Chiao Tung University. These data include normal traffic and abnormal traffic, the former one being majority. We propose a processing method with high accuracy. We first pre-sampled the data set, and then analyzed the data features. Later on, based on theoretical research, we integrated the model of random forests and other boosting method and proposed a greedy multi-classification to binary classification model based on ensemble learning model.
Validity of separable BKZ model for large amplitude oscillatory shear

Large amplitude oscillatory shear (LAOS) is a useful tool for the study of nonlinear viscoelasticity in polymeric liquids. To concisely describe the response of a material to such a test, it is desirable to make use of a constitutive equation. In this way, the response can be described in terms of the parameters of the rheological model. We have found a separable BKZ model, e.g., Wagner’s equation, to be useful in this regard for LDPE IUPAC X. The damping function determined in step shear experiments does not lead to accurate predictions of the LAOS response. For a given low frequency, however, it is possible to fit the parameters of a simple damping function equation to the LAOS response at one strain amplitude and to use these parameter values to reliably predict the response at other strain amplitudes. Thus, the Wagner equation provides a basis for the concise description of the response of LDPE IUPAC X to large amplitude oscillatory shear experiments at low frequencies. Conversely, it was found that the response of a HDPE melt to large amplitude oscillatory shear cannot be concisely described by the Wagner equation.
Multi-attention prior based residual encoder-decoder network for fast and accurate reconstruction in fluorescence molecular tomography

Fluorescence molecular tomography (FMT) is a powerful modality for resolving the three-dimensional (3D) distribution of fluorescent targets inside biological tissues. However, the inverse problem of the FMT is severely ill-posed due to the strong scattering effects of photons inside biological tissues. Previously, regularization-based methods have been widely used to mitigate the ill-posedness of FMT. Due to the complex iterative computation and time-consuming reconstruction process, the FMT remains an intractable challenge for achieving accurate and fast 3D reconstructions. In this work, we propose a multi-attention prior based residual encoder-decoder network (MAP-REDN) to perform FMT reconstruction. Firstly, the multi-attention mechanism can provide weighted a priori information to the fluorescence source, enabling MAP-REDN to effectively mitigate the ill-posedness and enhance the reconstruction accuracy. Secondly, since the direct reconstruction strategy is adopted, the complex iterative computation process in the traditional regularization-based algorithms can be avoided, thus tremendously accelerating the reconstruction process. The experimental results demonstrate the feasibility of the MAP-REDN in achieving accurate and fast FMT reconstruction.