Miracle-dz/UniFAR-FTUs huggingface dataset:
Barriers to Effective Curriculum Implementation.

An administration of a private school located in the south reported the problem of a lack of curriculum fidelity to a new phonics program, which created a need to identify barriers preventing full curriculum implementation. Using the concerns-based adoption model (CBAM) as the conceptual framework, this qualitative case study identified concerns and barriers teachers report when implementing a new curriculum. Data were collected from 10 participants (8 teachers and 2 administrators) through a questionnaire, interviews, and observations. Participants were interviewed to identify any barriers experienced with curriculum fidelity of a new phonics program. Teachers were observed to determine which components of the curriculum were present in or omitted from their lessons. Participants completed a questionnaire to determine their levels of concern when asked to implement a new curriculum. Results indicated that teachers required additional information before the expected implementations occur and an understanding of demands on their personal time. Common themes showed a desire for professional development (PD), peer-collaboration, and access to curriculum resources, which served as the basis for the project. The resulting project integrated PD to address concerns connected to reoccurring themes. Implications for social change include change at a systematic level by providing administrators with data to support teachers during curriculum changes and substantiation for the benefits of understanding concerns prior to a change for improving curriculum fidelity.
KNOWLEDGE, ATTITUDES AND PERCEPTIONS OF STROKE AMONG THE COMMUNITY: A CROSS-SECTIONAL SURVEY IN TABUK CITY, SAUDI ARABIA

: Background: The overall global burden of stroke or cerebrovascular accident in Saudi Arabia is great and increasing. The community knowledge of stroke symptoms has an effect on early recognition and thereby the mortality and morbidity rates. Objective: The aim of this study was to assess the knowledge and attitude of the community about stroke risk factors and symptoms in Tabuk city, Saudi Arabia. Methods: In this cross sectional study, questionnaires were distributed on a random sample from the population of Tabuk city after obtaining an informed consent. A total of 350 study participants were enrolled into this study. Results: Two hundred and thirty six (67.4%) of participants were females with a median age (IQR) of 29 (21–40) years. More than half (52.3%) of the participants correctly identified stroke as a disorder of the brain. Two hundred and seventy two subjects (77.7 %) knew at least one risk factor for stroke, and 44.5% of them identified that a combination of hypertension, atherosclerosis, obesity and smoking are stroke risk factors. Most of participants (74.0%) knew warning signs of stroke. Analysis of factors associated with knowledge of one or more warning signs revealed only a significant relationship with the knowledge of stroke risk factors (p>0.05). Nearly half (55.1%) of the participants showed a positive attitude of rapid seeking of medical help by going to hospital either at once or after calling general practitioner or family physician. Conclusion: There was a lack of knowledge about the organ affected and warning signs of stroke. Also, the proper attitude in cases of stroke was not clear to all participants. This requires more awareness strategies including health education by specialists.
Efﬁcacy and Safety of Pharmacokinetically Enhanced Amoxicillin-Clavulanate at 2,000/125 Milligrams Twice Daily for 5 Days versus Amoxicillin-Clavulanate at 875/125 Milligrams Twice Daily for 7 Days in the Treatment of Acute Exacerbations of Chronic Bronchitis

This randomized, controlled trial was designed to show that a short, 5-day course of pharmacokinetically enhanced amoxicillin-clavulanate at 2,000/125 mg (Augmentin XR) is as effective clinically as a longer, 7-day course of conventional amoxicillin-clavulanate at 875/125 mg (both given twice daily) in the treatment of acute exacerbations of chronic bronchitis (AECB). Amoxicillin-clavulanate at 2,000/125 mg was designed to extend the therapeutic levels of amoxicillin in serum over the 12-h dosing interval, compared with conventional formulations, to eradicate bacterial strains for which amoxicillin MICs were < 4 (cid:1) g/ml while retaining efﬁcacy against (cid:2) -lactamase-producing pathogens. A total of 893 patients were randomized and received study medication (amoxicillin-clavulanate at 2,000/125 mg for 443 patients and 875/125 mg for 450 patients). Overall, 141 patients receiving amoxicillin-clavulanate at 2,000/125 mg and 135 receiving the comparator formulation had at least one pathogen identiﬁed at screening. Amoxicillin-clavulanate at 2,000/125 mg was as effective clinically in the per-protocol (PP) population at the test of cure (days 14 to 21, primary efﬁcacy endpoint) as amoxicillin-clavulanate at 875/125 mg (clinical success rates of 93.0 and 91.2%, respectively; treatment difference, 1.8; 95% conﬁdence interval [CI], (cid:3) 2.2, 5.7). Bacteriological success in the bacteriology PP population was high for both formulations (amoxicillin-clavulanate at 2,000/125 mg, 76.7%; amoxicillin-clavulanate at 875/125 mg, 73.0%; treatment difference, 3.8; 95% CI, (cid:3) 7.5, 15.0). Both therapies were well tolerated, with a similar incidence of adverse events. Fewer than 5% of patients in each group withdrew from the study due to adverse events. The shorter, 5-day course of amoxicillin-clavulanate at 2,000/125 mg was shown to be as effective clinically as a longer, 7-day course of amoxicillin-clavulanate at 875/125 mg, with high bacteriological efﬁcacy and no difference in tolerability. clavulanate at 2,000/125 mg (cid:7) group with amoxicillin-clavulanate at 875/125 mg) was no less than (cid:7) 10%. The study was not powered to provide statistically signiﬁcant results at secondary endpoints.
Luteal Blood Flow and progesterone concentration during first and second postpartum estrous cycle in lactating dairy cows.

The aim of the present study was to determine the differences in corpus luteum (CL) functionality between the first postpartum estrous cycle and the following cycle in lactating dairy cows. Luteal blood flow (LBF), luteal size and blood progesterone (P4) concentration were monitored during the first and second postpartum estrous cycle. During the first and second postpartum estrous cycle, the mean LBF value increased (P<0.05) from early to late diestrus, while it decreased rapidly in proestrus, resulting statistically lower (P<0.05) than those registered in all previous phases. Statistically significant differences were not observed between overall LBF during first and second postpartum estrous cycle (P>0.05). During the first postpartum estrous cycle, P4 blood concentrations showed a significant reduction (P<0.05) from diestrus to proestrus. A different trend of P4 concentrations was observed during the second postpartum estrous cycle, where mean P4 value registered in proestrus resulted statistically lower than those registered in the previous cycle phases (P< 0.05). The mean P4 concentration registered over the first postpartum estrous cycle resulted statistically lower (P<0.05) than that registered during the second one. A significant correlation between P4 concentrations and LBF was registered only during the second postpartum estrous cycle. Results indicate that during the first postpartum estrous cycle P4 concentration was independent of luteal blood flow and luteal size. This article is protected by copyright. All rights reserved.
Trapped metastable phases in Pb(Zn1/3Nb2/3)O3-(8-9)%PbTiO3 single-crystal wafers

In addition to locally stressed rhombohedral phase, evidence for trapped metastable phases in (001)-cut single-crystal wafers of Pb(Zn1/3Nb2/3)O3–(8–9)%PbTiO3 has been obtained by means of the x-ray diffraction technique. The rhombohedral phase is stressed predominantly in compression in the plane of the wafer, both in unpoled and poled conditions, giving rise to the broad shoulder at the lower 2θ end of the rhombohedral peak. Trapped tetragonal phase, with its c axis lying both in the plane and perpendicular to the plane of the wafer, can also be detected in as-sliced, unpoled wafers. Upon poling along the [001] thickness direction, the tetragonal phase with its c axis lying in the plane of the wafer is transformed readily to the rhombohedral phase. In contrast, a minute amount of tetragonal phase with its c axis perpendicular to the plane of the wafer can be stabilized by the stressed rhombohedral matrix in poled state. At sufficiently high poling fields (i.e., ⩾1.2 kV/mm), a trapped pseudomonoclinic ph.
A CLINICAL APPROACH TO DIABETIC PERIPHERAL NEUROPATHY

: Diabetes mellitus is characterized by increased blood sugars, which can lead to multiple macrovascular and microvascular problem. It is also a known cause of debilitating problem like peripheral neuropathy (PN). This review is done to explain the importance of detecting peripheral neuropathy in a clinical practice. PN causes discomfort and pain in the lower extremities, loss or absence of sensations in the lower extremities leading to postural problems, risk of ulcerations of foot, and reduced quality of life in patients with Type 2 Diabetes. A variety of methods are used to evaluate peripheral nerve functions (objective and subjective measures). It is important to understand how to evaluating PN in routine practice and preventing foot ulcers or fall-related morbidity and mortality in adults with Type 2 Diabetes.
SECOND ORDER UV CONTAMINATION IN ASTRONOMICAL SPECTRA

Observations of the planetary nebula Me 2-1 are used to discuss some effects of contamination produced by the second order ultraviolet spectrum in the first order red, longer than approximately 6200 A. It is found that this contamination is present with some instrument set-ups, and that the contaminating lines are displaced in wavelength with respect to the predictions from diffraction theory by an amount which varies slightly for different set-ups. From the theoretical and empirical analysis of these displacements, it is concluded that the shift in wavelength is due to the presence of chromatic difference in magnification in spectrograph cameras including any transmission element, as is the case in teh semi-solid Schmidt-Cassegrain cameras used in our observations.
CONCISE COMMUNICATION Immunization with Haemophilus inﬂuenzae Type b–CRM 197 Conjugate Vaccine Elicits a Mixed Th1 and Th2 CD4 + T Cell Cytokine Response That Correlates with the Isotype of Antipolysaccharide Antibody

Haemophilus inﬂuenzae type b (Hib) capsular polysaccharide (PS) induces protective antibodies but is T independent and poorly immunogenic in infants. Conjugate vaccines of Hib PS linked to proteins, such as CRM 197 , increase the PS antibody titer and elicit immunologic memory. To deﬁne the conjugate-induced memory T cell response, 19 adults were immunized with Hib-CRM 197 , and antibody titers, carrier protein–speciﬁc CD4 + T cell proliferation, and cytokine production were measured. Hib-CRM 197 induced PS and CRM 197 antibodies, vigorous T cell recall responses, and production of cytokines, including interleukin (IL)–2, IL-5, IL-10, and interferon- g . There was marked variability in PS antibody titer, despiteconsistent CRM 197 -speciﬁc recall responsiveness, which correlated with peak IgM and IgA PS antibody titers. Correlations were also found between IL-2 and IL-5 and IgA PS antibody levels. Hib-CRM 197 induced a rapid increase in CRM 197 -speciﬁc memory T cells and mixed Th1/Th2 cytokines, which may regulate the isotype and quantity of PS antibody.
S Sepsis guidelines: Clinical practice implications

population ages. 1 Other reasons for rising sepsis rates include increased recognition of the sepsis continuum, multidrug antibiotic-resistant organisms, and increasing longevity of people with or immunocompromised Abstract: The Surviving Sepsis Campaign 2012 Guidelines offer recommendations for the care of severely septic patients. These guidelines are appraised and summarized brieﬂ y in this article, and a case example illustrates the integration process. These guidelines are important for multidisciplinary team members working together toward the common goal of reducing sepsis mortality.
and STAT3 g RORAutoimmune Encephalomyelitis by Targeting and the Pathogenesis of Experimental miR-20b Suppresses Th17 Differentiation

The differentiation and function of IL-17–producing Th17 cells are tightly regulated by speciﬁc transcription factors and cytokines, which are the key participants in the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Although speciﬁc miRNAs have been shown to be involved in the development of MS and EAE, the potential role of miRNAs in the context of Th17-driven autoimmunity is just beginning to be clariﬁed. miR-20b has been reported as a downregulated miRNA in blood cells of MS patients. In this report, it was further studied in greater detail because we found it was signiﬁcantly downregulated during EAE, and, in the in vitro differentiation model, Th17 cells had lower expression of miR-20b than did Th1, Th2, or inducible T regulatory cells. Ectopic expression of miR-20b repressed Th17 differentiation in vitro. Using lentiviral vectors for miR-20b overexpression in vivo, we demonstrated that overexpression of miR-20b led to decreased Th17 cells and reduced severity of EAE. Furthermore, we also identiﬁed both RAR-related orphan receptor g t and STAT3 as potential targets of miR-20b. Finally, we conﬁrmed that the mild disease severity and low number of Th17 cells in LV-miR-20b–infected mice were largely reversed by coinfection of these mice with lentivirus-expressing RAR-related orphan receptor g t or STAT3 3 9 untranslated regions. Taken together, our results contribute to the importance of miRNAs in Th17 differentiation and pathogenesis of MS and EAE. The Journal of Immunology , 2014, 192: 000–000.
Nuclear Translocation Tristetraprolin through Blocking NF-?B Suppression of IL-12 Production by

Tristetraprolin (TTP), an mRNA-binding protein, plays a signiﬁcant role in regulating the expression of adenylate-uridylate–rich elements containing mRNAs. Mice deﬁcient of TTP (TTP 2 / 2 ) develop a systemic autoimmune inﬂammatory syndrome characterized by cachexia, conjunctivitis, and dermatitis. IL-12 plays a crucial role in immune defense against infectious and malignant diseases. In this study, we found increased production of IL-12 during endotoxic shock and enhanced Th1 cells in TTP knockout mice. The levels of IL-12 p70 and p40 protein as well as p40 and p35 mRNAwere also increased in activated macrophages deﬁcient of TTP. In line with these ﬁndings, overexpression of TTP suppressed IL-12 p35 and p40 expression at the mRNA and promoter level, whereas it surprisingly had little effects on their mRNA stability. Our data showed that the inhibitory effects of TTP on p35 gene transcription were completely rescued by overexpression of NF- к B p65 and c-Rel but not by the p50 in activated macrophages. Our data further indicated that TTP acquired its inhibition on IL-12 expression through blocking nuclear translocation of NF- к B p65 and c-Rel while enhancing p50 upon stimulation. In summary, our study reveals a novel pathway through which TTP suppresses IL-12 production in macrophages, resulting in suppression of Th1 cell differentiation. This study may provide us with therapeutic targets for treatment of inﬂammatory and autoimmune disorders. The Journal of Immunology , 2013, 191: 000–000.
Analysis of Heart Sounds for Diagnosis of Pulmonary Artery Hypertension in Newborns

: With the technology advancement in recent years, many studies have been conducted on the diagnosis of heart disease and especially diagnosis of Pulmonary Artery Hypertension (PAH), since the clinical diagnosis of this disease is very difficult, using audio signal processing and spectral analysis of the fetal heart sound recordings, have given us an appropriate opportunity for PAH diagnosis. Our discussion in this study is the difference between heart sound recordings of children with PAH and those without PAH. This is the goal of our study in fact. In order to prove this theory and perform the study, we used number of infants with PAH less than 25 mm Hg (between 8 – 24 mm Hg) as healthy cases and several other with PAH greater or equal to 25 mm Hg (between 25 – 97 mm Hg), recording their heart sounds with an innovative and low cost method. It should be noted that for processing the resulted signals from recorded heart sounds, the non-linear cepstrum method were used and power spectral analysis were done in Matlab software. The obtained results in this study would suggest that the spectrum frequency range are close to the frequencies 15 – 25 Hz of the recorded heart sounds for those patients that their second left intercostal space were examined for getting the heart sound. The spectrum frequency range in people with PAH greater or equal to 25 mm Hg is considerably decreased in compare with those with PAH lower than 25 mm Hg. So the conclusion is that heart sound signals in PAH patients notably have a lower extent comparing with normal PAH people. The obtained data in frequency scope may be helpful in better diagnosis of PAH and also help the techniques and methods’ developments in auscultation the heart sounds for PAH diagnosis. In future, with regards to the available data and using them for diagnosis of such diseases, their analysis in time and frequency extent may be required.
Harmonic Analysis and Switching Angle Calculation by Equal Phase Method for Cascade H-Bridge five level Inverters

Multilevel inverters have become very popular in the last few years, due to their advantages over the conventional two level inverters, in producing sinusoidal waveform with low distortion, high quality and high efficiency. Many topologies of multilevel inverter have been proposed during the last three decades, aiming to construct a sinusoidal waveform. It is hard to connect a single power semiconductor switch directly to medium voltage grids (2.3, 3.3, 4.16, or 6.9 kV). For these reasons, a new family of multilevel inverters has emerged as the solution for working with higher voltage levels. Multilevel inverters have received more attention in industrial application, such as motor drives, static VAR compensators and renewable energy systems, etc. Primarily multilevel inverters are known to have output voltages with more than two levels. As a result, the inverter output voltages have reduced harmonic distortions and high quality of waveforms. Additionally, the devices are confined to fraction of dc-link voltage. These characteristics make multilevel inverter to adopt for high-power and high-voltage applications. Although different multilevel inverter exists, Cascade Multilevel Inverter (CMI) is one of the productive topology from multilevel family. In reality, on comparing with other multilevel based topologies, CMI feature a high modularity degree because each inverter can be seen as a module with similar circuit topology, control structure, and modulation. Therefore, in the case of a fault in one of these modules, it is possible to replace it quickly and easily. Moreover, with an appropriated control strategy, it is possible to bypass the faulty module without stopping the load, bringing an almost continuous overall availability. All this features make CMI an outstanding power converter.
Engineering high-level production of fatty alcohols by cerevisiae from lignocellulosic feedstocks.

Fatty alcohols in the C12-C18 range are used in personal care products, lubricants, and potentially biofuels. These compounds can be produced from the fatty acid pathway by a fatty acid reductase (FAR), yet yields from the preferred industrial host Saccharomyces cerevisiae remain under 2% of the theoretical maximum from glu- cose. Here we improved titer and yield of fatty alcohols using an approach involving quantitative analysis of protein levels and metabolic ﬂ ux, engineering enzyme level and localization, pull-push-block engineering of carbon ﬂ ux, and cofactor balancing. We compared four heterologous FARs, ﬁ nding highest activity and endoplasmic reticulum localization from a Mus musculus FAR. After screening an additional twenty-one single-gene edits, we identi ﬁ ed increasing FAR expression; deleting competing reactions encoded by DGA1 , HFD1 , and ADH6 ; overexpressing a mutant acetyl-CoA carboxylase; limiting NADPH and carbon usage by the glutamate dehydrogenase encoded by GDH1 ; and overexpressing the Δ 9-desaturase encoded by OLE1 as successful strategies to improve titer. Our ﬁ nal strain produced 1.2 g/L fatty alcohols in shake ﬂ asks, and 6.0 g/L in fed-batch fermentation, corresponding to ~ 20% of the maximum theoretical yield from glucose, the highest titers and yields reported to date in S. cerevisiae . We further demonstrate high-level production from lignocellulosic feedstocks derived from ionic-liquid treated switchgrass and sorghum, reaching 0.7 g/L in shake ﬂ asks. Altogether, our work represents progress towards e ﬃ cient and renewable microbial production of fatty acid- derived products.
International Journal of Scientific Research in Computer Science, Engineering and Information Technology

The ranking fraud in the mobile Apps market leads to misleading and illusive activities which is used in keeping more and more Apps in the popularity list. The developers such as posting unauthentic App ratings, for the purpose of ranking, used many of the misguiding means. In this paper a comprehensive view of ranking fraud and a detection system for the mobile apps is given. The proposed method is based on the leading sessions of the mobile Apps and locating the ranking fraud by the active periods in them. Those leading sessions were used for detecting the global and local App rankings. Evidences like ranking based evidences, rating based evidences and review based evidences through statistical hypotheses tests were used. Finally, we evaluated the proposed system with real-world App data collected from the iOS App Store for a long time period. In the experiments, we also validated the effectiveness of the proposed system, and the scalability of the detection algorithm as well as some regularity of ranking fraud activities.
Rapid Bipedal Gait Design Using C-FROST with Illustration on a Cassie-series Robot

One of the big attractions of low-dimensional models for gait design has been the ability to compute solutions rapidly, whereas one of their drawbacks has been the difficulty in mapping the solutions back to the target robot. This paper presents a set of tools for rapidly determining solutions for "humanoids" without removing or lumping degrees of freedom. The main tools are: (1) C-FROST, an open-source C++ interface for FROST, a direct collocation optimization tool; (2) multi-threading; and (3) following the lead of the manipulator community, removing the Coriolis terms in the model. The results will be illustrated on a 20-DoF floating-base model for a Cassie-series bipedal robot through numerical calculations and physical experiments.
Universal Approaches for Overflow and Sign Detection in Residue Number System Based on {2 n – 1, 2 n , 2 n + 1}

—This paper presents two universal efficient approaches for overflow and sign detection and correction in the addition of two numbers in unsigned and signed residue number systems (RNS). Both methods are designed to be used in systems based on the moduli set {2 n – 1, 2 n , 2 n + 1} that provides an even dynamic range. Moreover, by applying a tiny modification, these designs can be used in any system that has (2 n ) as one of its moduli (i.e. has an even dynamic range). The proposed methods depend on a simple structure that provides fast and accurate detection and correction of the sign and overflow. A comparison, which proves the efficiency of the proposed designs, in terms of time and area requirements is also presented.