Miracle-dz/UniFAR-FTUs huggingface dataset:
Leucemia promielocítica aguda. Estado del arte

La leucemia promielocítica aguda (LPA) es un subtipo de leucemia mieloide aguda (LMA) que se origina por una traslocación balanceada entre los cromosomas 15 y 17, involucra al gen que codifica para el receptor alfa del ácido retinoico (RARA) en el cromosoma 17 y el de la leucemia promielocítica (PML) en el cromosoma 15, lo que da origen a la traslocación t(15;17) PML/RARA. Dicho reordenamiento origina la proteína de fusión PML/RAR alfa, que bloquea la diferenciación de las células madre mieloides en el estadio de promielocito. La LPA afecta con mayor frecuencia a adultos jóvenes y conlleva un alto riesgo de mortalidad temprana, en especial por el desarrollo de una coagulopatía grave, que sin tratamiento es definitivamente fatal. El diagnóstico temprano, el tratamiento de soporte y la introducción de fármacos que promueven la diferenciación terminal de los promielocitos patológicos como la tretinoina, también conocida como ácido todo transretinoico (ATRA) o trióxido de arsénico (ATO), ha hecho que en la actualidad esta sea una enfermedad curable con altas tasas de remisión completa.
Noble Metal Speciations in Hydrothermal Sulphides

A significant part of the primary gold reserves in the world is contained in sulphide ores, many types of which are refractory in gold processing. The deposits of refractory sulphide ores will be the main potential source of gold production in the future. The refractory gold and silver in sulphide ores can be associated with micro- and nano-sized inclusions of Au and Ag minerals as well as isomorphous, adsorbed and other species of noble metals (NM) not thoroughly investigated. For gold and gold-bearing deposits of the Urals, distribution and forms of NM were studied in base metal sulphides by laser ablation-inductively coupled plasma mass spectrometry and by neutron activation analysis. Composition of arsenopyrite and As-pyrite, proper Au and Ag minerals were identified using electron probe microanalysis. The ratio of various forms of invisible gold—which includes nanoparticles and chemically bound gold—in sulphides is discussed. Observations were also performed on about 120 synthetic crystals of NM-doped sphalerite and greenockite. In VMS ores with increasing metamorphism, CAu and CAg in the major sulphides (sphalerite, chalcopyrite, pyrite) generally decrease. A portion of invisible gold also decreases —from ~65–85% to ~35–60% of the total Au. As a result of recrystallisation of ores, the invisible gold is enlarged and passes into the visible state as native gold, Au-Ag tellurides and sulphides. In the gold deposits of the Urals, the portion of invisible gold is usually <30% of the bulk Au.
Microbiological Study in the case of Chronic Inflammatory Bowel Disease

The present study focused on the isolation and identification of the intestinal bacterial ecosystem involved in Crohn’s disease and Hemorrhagic ulcerative colitis. The patients were male and female with an age range of 18 to 60 years. The isolation carried out after grinding the different biopsies collected by means of low endoscopy, on specific selective culture media, made it possible to select a set of bacteria belonging to the intestinal ecosystem. The data were identified phenotypically through the use of biochemical tests, the various API galleries. On the other hand, the anatomopathological study made it possible to pose and confirm the different diagnoses of the pathologies corresponding to our research study. During Gram staining microscopic observation, in the case of Crohn’s disease and Hemorrhagic ulcerative colitis, the identification is mainly represented by the Gram-positive bacilli identified as Clostridium difficile and Bacillus subtilus. These bacterial strains secrete toxins capable of causing an inflammatory state in the intestinal mucosa and thus inducing their pathogenic powers which can cause an immune disorder in these patients. Nevertheless, the Bacillus subtilus strain presents itself as an agent which can induce a defense against the aggressiveness of pathogenic bacteria.
Synergistic modulation of metal-free photocatalysts by the composition ratio change and heteroatom doping for overall water splitting

Graphitic carbon nitride (g-C3N4) based metal-free photocatalysts have attracted growing attention in recent years, while the efficiency is largely limited by the slow reaction rate of the oxygen evolution reaction (OER) and fast recombination of photo-generated electron–hole pairs. In this study, we show that the photocatalytic activity for water oxidation can be better improved by the synergistic effect on electronic structures, including the N ratio change and heteroatom doping. Pristine g-C3N4 presents poor OER activity due to strong binding with the intermediates of *OH and *O, which can be weakened significantly by reducing the ratio of N in g-C3N3 and g-C2N. Furthermore, binding with all the intermediates during the OER process can be further modulated by heteroatom doping. In particular, low overpotentials of 0.37 V and 0.38 V are obtained on S-doped g-C3N3 and g-C2N, respectively. More importantly, the introduced impurity bands by S-doping can effectively trap the photo-generated holes for water oxidation and thus improve the photocatalytic efficiency, which is demonstrated by the nonadiabatic molecular dynamics simulations. Besides, other characteristics for photocatalysts, including band edges, light absorbance, thermal stability and so on, are also evaluated. The systematic study provides insight into modulation mechanisms for electronic structures by commonly applied approaches in experiments and guidance on the performance optimization of carbon nitride based metal-free photocatalysts.
Effect of the anomalous magnetic moment of quarks on magnetized QCD matter and meson spectra

We systematically investigate the effect of the anomalous magnetic moment(AMM) of quarks on the magnetized QCD matter, including the magnetic susceptibility, the inverse magnetic catalysis around the critical temperature and the neutral/charged pion and rho meson spectra under magnetic fields. The dynamical AMM of quarks, its coupling with magnetic field causes Zeeman splitting of the dispersion relation of quarks thus changes the magnetism properties and meson mass spectra under magnetic fields. It is found that including the AMM of quarks cannot fully understand lattice results of the magnetized matter: The AMM of quarks reduces the dynamical quark mass thus causes the inverse magnetic catalysis around $T_c$. The neutral pion mass is very sensitive to the AMM, it decreases with magnetic field quickly, and the charged pion mass shows a nonlinear behavior, i.e., firstly linearly increases with the magnetic field and then saturates at strong magnetic field. For rho meson, it is observed that AMM reduces the mass of neutral rho meson mass with different $s_z$, and reduces the mass of $s_z=+1,0$ component charged rho meson mass but enhances the $s_z=-1$ component charged rho meson mass. The magnetic susceptibility at low temperature can be either positive or negative with different AMM.
Time-delay interferometry without delays

The space-based gravitational-wave observatory LISA relies on a form of synthetic interferometry (time-delay interferometry, or TDI) where the otherwise overwhelming laser phase noise is canceled by linear combinations of appropriately delayed phase measurements. These observables grow in length and complexity as the realistic features of the LISA orbits are taken into account. In this paper we outline an implicit formulation of TDI where we write the LISA likelihood directly in terms of the basic phase measurements, and we marginalize over the laser phase noises in the limit of infinite laser-noise variance. Equivalently, we rely on TDI observables that are defined numerically (rather than algebraically) from a discrete-filter representation of the laser propagation delays. Our method generalizes to any time dependence of the armlengths; it simplifies the modeling of gravitational-wave signals; and it allows a straightforward treatment of data gaps and missing measurements.
Medical Students’ Readiness for Virtual Clerkships During the COVID-19 Pandemic.

BackgroundThis study aims to qualitatively examine the readiness of medical students to change to virtual clerkship during the pandemic, from both the faculty preceptors and students’ perspectives’. MethodsA qualitative study was conducted based on the framework of readiness to change. Focus group discussions with students, and semi-structured interviews with clinical faculty members were done using appropriate online platforms. Transcripts were then analyzed using a qualitative phenomenological approach.Results Twelve themes emerged which are 1) Perceptions about the university decision and its communication to students, 2) A Perceived Lack of clinical experience, 3) Student safety , 4) Students’ role as members of the medical team facing the pandemic, 5) Quality and design of VI and the skills it offered, 6) Belief in own ability to succeed in the VC, 7) Confidence that VC would reach its goals, 8) New enhanced learning approaches, 9) Acquired skills, 10) Preparing students for new types of practice in the future, 11) Academic support and communication with faculty and college, 12) Psychological support. Medical students showed limited readiness to undertake a virtual clerkship and not play their role as healthcare professionals during the pandemic. They perceived a huge gap in gaining clinical skills virtually and asked for quick return to training sites.ConclusionsMedical students were not ready for virtual clerkships. There will be a need to integrate novel learning modalities such as patient simulations and case-based learning in order to meet future demands of the medical profession and enhance the efficiency of virtual clerkships.
Assessment of Several Approaches to Biofortified Products: A Literature Review

The aim of this study is to provide a literature review on biofortified products and their role in the scientific sphere. Despite the large number of studies conducted on biofortified products in the last 20 years, many defining issues are still debated in the literature and several research questions should be clarified. It is therefore relevant to investigate more on this topic, which is considered increasingly important to human health, world hunger reduction strategy, and also for the international marketing strategy of production holdings. The papers were analyzed according to a chronological/conceptual approach, with greater emphasis on research that has added significant value to the literature. The research was carried out using a scientific database from which 1189 scientific papers were extracted. A careful analysis of the abstracts and the text led to the identification of the five dimensions of our greatest interest (Reducing world hunger; Human health; GMOs; Agronomy, herbaceous crops; Economy and the market). The suggestions for future research reported by various authors are organized and structured in order to create an incentive for new studies and insights into biofortification.
Losses Pipes in Sprinkler Irrigation Based IoT

Sprinkler irrigation is an alternative irrigation technology that is theoretically more efficient than open channel irrigation. Sprinkler irrigation can reduce water losses caused by percolation and runoff. In industrial age 4.0, modern technology is highly influential in everyday life, including the IoT in sprinkler irrigation. Research and design of sprinkler irrigation based on IoT has been carried out extensively. Still, the understanding of water loss factors is not fully understood, and something new is needed to determine a better assessment of incidence. For this, the power loss test in sprinkler irrigation canals based on IoT is carried out on a laboratory scale. The statistical analysis shows that the relationship between discharge and head loss is y = −3E − 08x4 + 4E − 07x3 − 2E − 06x2 + 2E − 06x + 0.0002 with a value of R2 = 0.9495.
Reflections From Applying Intersectionality to a Constructivist Grounded Theory Study on Intimate Partner Violence and Trauma

In this research note, I reflect on conducting a qualitative study on trauma and intimate partner violence (IPV), applying an intersectional lens to constructivist grounded theory methodology. I argue that despite offering an ability to critically examine socially constructed categories of identity, and providing a way to ensure the active inclusion of social justice goals into research, intersectionality is underused within social work research. I also reflect on the particular importance of an intersectional lens in countering the previously identified assumptions of sameness underlying IPV and trauma services. From recounting my research process, I discuss recommendations for further intersectional research, and research on trauma. Recommendations include allowing enough time for recruitment and analysis, making visible the researcher’s role, including a participatory element in studies, and ensuring continuous critical and reflexive processing at all research stages.
Anthropogenic Warming and Population Growth May Double US Heat Stress by the Late 21st Century

Globally, heat stress (HS) is nearly certain to increase rapidly over the coming decades, characterized by increased frequency, severity, and spatiotemporal extent of extreme temperature and humidity. While these characteristics have been investigated independently, a holistic analysis integrating them is potentially more informative. Using observations, climate projections from the CMIP5 model ensemble, and historical and future population estimates, we apply the IPCC risk framework to examine present and projected future potential impact (PI) of summer heat stress for the contiguous United States (CONUS) as a function of non‐stationary HS characteristics and population exposure. We find that the PI of short‐to‐medium duration (1–7 days) HS events is likely to increase more than three‐fold across densely populated regions of the U.S. including the Northeast, Southeast Piedmont, Midwest, and parts of the Desert Southwest by late this century (2060–2099) under the highest emissions scenario. The contribution from climate change alone more than doubles the impact in the coastal Pacific Northwest, central California, and the Great Lakes region, implying a substantial increase in HS risk without aggressive mitigation efforts.
Hazardous Alcohol Drinking and Associated Factors Among Patients with Tuberculosis Attending Public Healthcare Facilities in Gedeo Zone, Southern Ethiopia

Background: Hazardous drinking is a quantity or pattern of alcohol consumption that places individuals at risk for adverse health events. Studies have shown that hazardous alcohol drinking among patients with tuberculosis has been often linked to a decrease in immune system functioning, greater rates of treatment-resistant cases, and death during treatment. However, there are rare studies that assessed the prevalence of hazardous alcohol use and associated factors among patients with tuberculosis in Ethiopia. Therefore, this study was aimed to assess the prevalence of hazardous alcohol drinking and associated factors among patients with tuberculosis attending public healthcare facilities in Gedeo Zone, Southern Ethiopia.Methods: An institution-based, cross-sectional study was conducted among a randomly selected sample of 415 patients with tuberculosis. The study was conducted at the tuberculosis unit of public healthcare facilities in the Gedeo zone, Southern Ethiopia. The Alcohol Use Identification Test (AUDIT) scale was used to measure hazardous alcohol drinking. Data on social support, perceived tuberculosis stigma, and depression were collected using a standard, validated, and structured questionnaire. Results: The prevalence of hazardous alcohol drinking in our study was 20 % (95% CI; 16.1% -24.2%). Medical comorbidity (AOR = 2.44, 95% CI: 1.29–4.62), length of illness (>=12 months) (AOR = 2.88, 95% CI: 1.03–3.04), and being male (AOR = 2.10, 95% CI: 1.17–3.77) were found to be significant predictors of hazardous alcohol drinking after controlling for potential confounders.Conclusion: A high prevalence of hazardous alcohol drinking was observed among patients with tuberculosis. Therefore, routine screening for alcohol use and a holistic treatment approach for patients with tuberculosis are crucial.
RGraph: Asynchronous graph processing based on asymmetry of remote direct memory access

The scale of real‐world graphs is constantly growing. To deal with large‐scale graphs, distributed graph processing has attracted much research efforts. Existing distributed graph processing systems are commonly built on traditional TCP/IP communication stack, which leads to network bottleneck because of low bandwidth and heavy kernel stack operations. Meanwhile, in real power‐law graphs, the average number of mirror vertices after graph partitioning is very large, resulting in significant communication overhead among nodes. The emerging high‐performance Remote Direct Memory Access (RDMA) network has the features of low latency, high bandwidth, and low CPU overhead, which brings new opportunities for distributed graph processing systems. Existing RDMA‐assisted graph processing systems focus on synchronous execution, which imposes barriers between consecutive iterations. Synchronous execution transfers bulk data among nodes and thus only needs a small number of network transfers. However, synchronous execution is usually less efficient than asynchronous execution because of bulk synchronization. Asynchronous execution accelerates graph processing by eliminating barriers, which in turn requires to transfer a large amount of small size data. In this paper, we propose RGraph, an RDMA‐assisted asynchronous distributed graph processing system. RGraph distributes edges into two parts to isolate master and mirror vertices. RGraph exploits the asymmetry of RDMA to accelerate the one‐to‐many communication between master and mirror vertices. We implement RGraph on top of PowerGraph and conduct comprehensive experiments with large‐scale real graphs to evaluate its performance. Results show that compared to existing designs, RGraph reduces the execution time by up to 81%.
Effect of Drying Methods on Antioxidant Activity of Syzygium Caryophyllatum (L.) Fruit Pulp

ABSTRACT The perishable nature and seasonality of fruits make them harder to use in the food industry. Hence, the aim of this study is to preserve antioxidant-rich Syzygium caryophyllatum (L.) fruit using different drying techniques and evaluate the efficiency of drying methods in terms of antioxidant capacity. Fruits were dried using five different drying methods, namely, sun drying, dehumidified air drying, oven drying, vacuum drying, and freeze-drying. Highest 2,2-diphenyl-2-picryl-hydrazyl free radical scavenging activity (DPPH%) and Ferric reducing antioxidant power (FRAP) value retention were observed in vacuum drying and lowest in sun drying. Furthermore, during fruit drying, it is important to maintain the drying time as minimum as possible to minimize the loss of antioxidant activity. Therefore, vacuum drying was selected as the best drying method in preserving antioxidant-rich Syzygium caryophyllatum (L.) fruit pulp.
Divergence and Curl of COVID19 Spreading in Lower Peninsula of Michigan

Divergence and Curl concept in vector field is applied to the COVID19 spreading data for Lower Peninsula of Michigan State, U.S.A. The Divergence is an operator of COVID19 transmission vector field, which produces a scalar field giving the quantity of transmission vector field’s source at each location. The COVID19 spreading volume density of the outward flux of transmission field is represented by divergence around a given location. The Curl is an operator of COVID19 transmission field, which describes the circulation of a transmission vector field. The Curl at a location in COVID19 transmission field is represented by a vector whose length and direction denote the magnitude and axis of the maximum circulation. The curl of a transmission field is formally defined as the circulation density at each location of COVID19 transmission field. From data analysis of divergence of curl of Lower Michigan Peninsula, the COVID19 transmission volume flux and circulation can be identified for each County. Summary: This paper is to use vector Divergence and Curl concept to apply to COVID19 confirmed cases in Lower Peninsula of Michigan, U.S.A.
Energy budgets for coordinate invariant robot control in physical human–robot interaction

In this work we consider the current certification process of applications with physical human–robot interaction (pHRI). Two major hazards are collisions and clamping scenarios. The implementation of safety measures in pHRI applications typically depends strongly on coordinates, e.g., to monitor the robot velocity or to predict external forces. We show that the current certification process does not, in general, guarantee a safe robot behavior. In particular, in unstructured environments it is not possible to predict all risks in advance. We therefore propose to control the energy of the robot, which is a coordinate invariant entity. For an impedance controlled robot, the total energy consists of potential energy and kinetic energy. The energy flow from task description to physical interaction follows a strict causality. We assign a safe energy budget for the robot. With this energy budget, the presented controller auto-tunes its parameters to limit the exchanged kinetic energy during a collision and the potential energy during clamping scenarios. In contact, the robot behaves compliantly and therefore eliminates clamping danger. After contact, the robot automatically continues to follow the desired trajectory. With this approach the number of safety-related parameters to be determined can be reduced to one energy value, which has the potential to significantly speed up the commissioning of pHRI applications. The proposed technique is validated by experiments.
Identification and Characterization of Phenolic and Flavonoids Compounds Extracted from Tunisian Pomegranate Fruit Peel Exposed to Air Pollution: Gabes City, Tunisia

The pomegranate (Punica granatum) fruit peel exposed to mixture air pollutants were collected from two sites with different air quality around the industrial area of Gabes city, Tunisia. The first site presented the ‘Polluted site’, which is situated in the oasis close to the industrial area. While, the second site referred to the ‘Control site’ located at 37 km from the industrial area. Using HPLC ES-MS, 21 phenols were identified and quantified in methanol extract from pomegranate fruit peel. The results showed that various phytochemical substances, including phenols acids and flavonoids, were identified and quantified in the peel extract. The polyphenols content and the flavonoids contents in peel obtained from polluted site were higher than that collected from the control site. The concentrations of the identified polyphenols were ranged between 0.39 and 7803.68 mg/ kg DW. The stimulation of some free phenolic compounds such syringic acid, transfrulic acid, epicatechin, rutin and quercetin was enregistred only in peel collected from contaminated environment. The quali-qualitative changes between sites are probably related to the difference in the air quality. The increase of polyphenols could be implicated during adaptive mechanisms under air pollution. Phenolic composition changes in Punica granatum peel could be also suggested as useful approach air pollution monitoring.