Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk prediction models on adverse drug reactions: A review

Background: The risk prediction model has become increasingly popular in recent years in helping clinical decision-making. Existing models cannot be directly applied in Indonesia. Objective: To review the existing prediction models and their limitations. Method: A search related to the prediction of ADR risk was conducted using several journal databases: PubMed, Scopus and Google Scholar. Articles were screened to match specified criteria and further studied. Result: Nine articles met the criteria and were then analysed. Studies were carried out in various countries. The study population include; the elderly (>65 years, three studies), age (≥15 years, three studies), patients with Chronic Kidney Disease (CKD) (≥18 years, one study) and two studies in cancer patients. The outcomes were; ADR (five studies), ADE ( two studies), DRPs (one study), and cardiovascular effects (one study). The methods for determining the predictors of ADRs all used multivariable logistic regression. Conclusion: Each country has different treatment patterns, prescribing practices, traditions and drug distribution, so it is necessary to develop a prediction model for ADRs that is country-specific.
Identification of the key genes in chronic obstructive pulmonary disease by weighted gene co-expression network analysis

Background Chronic obstructive pulmonary disease (COPD) is prevalent mainly in older adults, especially those who are smokers. It appears to be regulated by multiple genes, but there is some degree of familial clustering. The evidence to date suggests that COPD-associated biomarkers are largely inadequate for disease diagnosis, so we conducted a comprehensive search for more specific genetic markers. Methods We used 3 datasets from the Gene Expression Omnibus (GEO) database. By investigating the biological information [i.e., Gene Ontology, Kyoto Encyclopedia of Genes and Genomes and weighted gene co-expression network analysis (WGCNA)], we filtered out 8 differentially expressed genes (DEGs) and validated the transcript levels of those hub genes in 16HBE cell lines, THP-1 cell lines and lung tissue of COPD patients. Results The 8 hub genes comprised amyloid precursor protein (APP), fibronectin 1, insulin-like growth factor 1 (IGF1), β-actin, capping actin protein of muscle Z-line subunit alpha 2, secreted phosphoprotein 1 (SPP1), catalase (CAT), and colony stimulating factor 2 (CSF2) were selected from among the DEGs. Cigarette smoke extract-stimulated 16HBE cells were found to highly express SPP1, CSF2, and IGF1. In addition, IGF1 levels were increased and IGF1 and APP levels were decreased in CSE-stimulated THP-1 cells. SPP1 and FN1 showed increased expression levels in lung tissue of COPD patients, but the opposite held for APP and CAT. Conclusions We identified 8 hub genes of COPD based on GO, KEGG and WGCNA, which have provided insights into the pathophysiological mechanisms of COPD.
Phenomenology, Quantity, and Numerosity

There are many situations in which we interact with collections of objects, from a crowd of people to a bowl of blackberries. There is an experience of the quantity of these items, although not a precise number, and we have this impression quickly and effortlessly. It can be described as an expressive property of the whole. In the literature, the study of this sense of numerosity has a long history, which is reviewed here with examples. I argue that numerosity is a direct perceptual experience, and that all experiences of numerosity, not only estimations, are affected by perceptual organisation.
Collocated measurements of boundary layer cloud microphysical and radiative properties: A feasibility study

[1] First data from collocated, helicopter-based measurements of boundary layer cloud microphysical properties (effective droplet radius Reff, droplet number concentration N) and spectral radiative quantities (cloud optical thickness τ, cloud top albedo ρ, reflectivity ) are presented. The in situ measurements of the microphysical cloud properties were collected by the Airborne Cloud Turbulence Observation System (ACTOS) attached to a helicopter by a 145 m long rope. Cloud spectral reflectivity was derived from radiances measured by grating spectrometers combined with downward looking optical inlets installed underneath the helicopter. Correlations between cloud microphysics and reflected radiation are presented for two cloud cases with different optical and geometrical thicknesses. On the basis of common retrieval techniques, τ and Reff are derived using a radiative transfer model. The results of the retrieval are compared to the collocated in situ measurements and data from the Moderate-Resolution Imaging Spectroradiometer (MODIS). Within the limitations of the relatively small data set, the feasibility of closely collocated microphysics and radiation data and their benefits were demonstrated.
An observational analysis of blood and urine testosterone in diagnosis of polycystic ovarian syndrome

Background: An important diagnostic tool for the diagnosis of Polycystic ovarian syndrome (PCOS) in women is elevated blood testosterone levels. The presence of testosterone in the urine is very likely to support the PCOS diagnosis; however, more investigation is required to determine whether blood testosterone levels are associated with PCOS. Objective: A total of 30 PCOS-positive women participated in this observational study using a diagnostic test approach. Method: The ELISA technique was used to measure the amounts of testosterone in the woman's urine and serum. Result: The levels of testosterone in the urine of 30 PCOS women were lower than those in the serum, with values of 2.688 nmol/L and 8.067 nmol/L, respectively. The Spearman correlation test findings revealed a value of 0.39 at a significance level of 0.05, with a cut-off value of 2.6010 nmol/L at sensitivity and specificity of 0.625 and 0.571, showing the importance of urine testosterone levels in detecting hyperandrogenic PCOS patients. Conclusion: In women with PCOS, serum and urine testosterone levels are correlated.
Gas Compressibility Factor Prediction Using Machining Learning Algorithmic Protocol for Niger – Delta Gas Reservoir

The gas compressibility factor also known as Z-factor plays an important role in obtaining thermodynamic properties of natural gas reservoir fluid property. Typically, empirical correlations and complex equation of state have been applied to determine this parameter in absence of laboratory measurements. However, high cost of running experimental measurement, poor performance and some limitations associated with these existing correlations have made the researchers to use intelligent models instead. Therefore, this study aimed at adopting support vector machine algorithm to forecast gas compressibility factor and to validate its performance with predictions from Artificial Neural network (ANN) and some existing correlations using statistical and performance plot analysis. A total of 519 data sets from Niger Delta was used in developing the model, out of it, 70 percent was used for training, 20 percent for testing and 10 percent for validation using MATLAB tool. From the statistical analysis result, it was observed that the new developed model did better than other existing methods with numerical value of 0.1997 rank, 0.0009 mean absolute error and 0.98 of coefficient of correlation using the test data. The cross plot of the support vector machine model gave the tightest cloud along 45o reference line. The residual (error) associated with the performance was impressive which was done to observe the distribution and the interval at which the error is minimal.
Turning Landscapes into ‘Nothing’: A Narrative on Land Reform in Namibia

The article is based on interviews with white commercial farmers in the upper Kuiseb catchment area in Namibia. Through narrative analysis and a political ecology approach, these farmers' attitudes to, and perceptions of, landscapes and land reform are explored. The main narrative of the commercial farmers portrays communal farmers as villains who will turn well-managed settler landscapes into ‘nothing’ if they are allocated land through redistribution. The commercial farmers see themselves as the heroes on whose knowledge and expertise both the ecology and economy of Namibia depend. It is the thesis of the article that this narrative is produced and reproduced not only by commercial farmers in Namibia but by a wide network of actors in southern Africa. Communal farmers, for their part, relate landscapes of ‘nothing’ to drought, which is more in line with the current wave of non-equilibrium ecosystem theory.
Impact of Internet Addiction, Social Media Use and Online Pornography on the Male Sexual Function in Times of the COVID-19 Pandemic

Over recent decades, the use of the Internet has dramatically increased, both for professional purposes and entertainment. We investigated the link between social media use, video games, dating apps, and pornography on men’s sexual health, which makes life easier, but also carries potential threats. Online surveys including The International Index of Erectile Function (IIEF) and Bergen Social Media Addiction Scale questionnaires were spread to young, sexually active men. We asked about demographics, sexual activity, and the use of social media, video games, dating apps, and pornography. We enrolled 702 men aged 18 to 60 years (mean 24.06 ± 5.70). In general, 1.6% of men were exposed to social media addiction. Social media addiction had a negative impact on IIEF scores, while pornography in general had no impact on men’s sexual health. However, more extensive use of pornography was correlated with lower IIEF scores. A negative impact of dating apps use on the IIEF score was also found but the correlation was weak (p = 0.049). No correlation was found between playing games and IIEF. We conclude that social media addiction negatively affected men’s sexual functioning during the COVID-19 pandemic. The development of strategies for the safe use of the Internet and dissemination of this knowledge through social media campaigns can help young people to recognize the first symptoms of social media addiction.
Watering up After Clear‐Cutting on Forested Wetlands of the St. Lawrence Lowland

Clear-cutting on wetlands of the St. Lawrence lowlands raised the water table levels on seven of the eight studied sites encompassing five forest types and four soil subgroups. Water table levels dropped 3 cm after clear-cutting on the eighth site, which was the wettest site with precut water levels within the top 10 cm. This was explained by evaporation from exposed water surfaces. The magnitude of the water table rises increased with the depth of the precut water table. The seasonal mean and maximum rise were respectively 20 and 52 cm on a poorly drained mineral soil which had the lowest precut water table levels. The smallest rises, with means around 7 cm, were associated with high precut water table on bogs and on fens. The watering up was not reduced on fens where a lateral flow occurs. This study indicated that transition sites between the bogs or fens and the uplands were most susceptible to hydrologic changes after clear-cutting. Watering up was caused by reduced evapotranspiration, of which the major component was interception. The rise of the water table observed in the clear-cut and the bordering forest indicates that clear-cutting in narrow strips is not an effective solution to avoid water table rise. Silvicultural treatments to maintain interception and transpiration by leaving logging debris, small trees, and preestablished regeneration would be more effective.
A Single Transradial Guiding Catheter in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A Door-to-Balloon Optimized Strategy

Background Acute coronary syndrome (ACS) is the leading cause of morbidity and mortality worldwide. The different reperfusion strategies have evolved over the years, and efforts have been directed to reduce its complications. Among these strategies, the one that has shown the best results is percutaneous coronary intervention, which has significantly improved the survival and prognosis of these patients; however, this procedure is not free of complications since multiple factors are involved. Among them is the time of patient care from the time of diagnosis until the coronary reperfusion therapy is performed. Methodology In this study, we describe the experience in our center with the 6-French Ikari Left guide catheter as a strategy of radial angiography-angioplasty with a single catheter to reduce the care times of patients with acute ST-elevation myocardial infarction (STEMI) in our center and compare it with the series reported by other international centers since. To establish an alternative to the usual approach that consists of the use of Judkins catheters, diagnosis, and guiding. Results Our study showed a success rate for diagnostic angiography and percutaneous coronary intervention (PCI) with the 6- French Ikari Left catheter comparable to those obtained in other centers, even with lower complication rates than the usual approach with Judkins’ Catheters. Conclusions The use of the 6-French Ikari Left catheter demonstrated shorter needle-device time and compared to other international series, it was shown to be shorter and related to shorter fluoroscopy time. Our study has a small sample and only included a highly selected population, which represents a limitation. This study is vulnerable to the different practices of the operators, with involvement in procedure time and use of contrast volume.
The Leeuwin Current off Western Australia, 1986–1987

Abstract The Leeuwin Current in the Indian Ocean off Western Australia differs from the other major eastern boundary currents, e.g., California Current, since it flows rapidly poleward against the prevailing equatorward wind. The first large-scale study of the Leeuwin Current was conducted between North West Cape (22°S) and the south-western corner of Australia (35°S) from September 1986 to August 1987. As part of this Leeuwin Current Interdisciplinary Experiment (LUCIE), current meters were deployed along the shelf-edge (from 22° to 35°S) and across the shelf and upper slope (at 29.5° and 34°S), and CTD surveys were made out from the shelf at several latitudes. Except for about one month (January) the flow between the surface and about 250 m was strongly poleward within 100 km of the shelf-edge, with a poleward transport of about 5 Sv (Sv ≡ 6 m3 s−1). The 325-day mean currents at the shelf-edge were poleward at about 10 cm s−1, opposing a mean equatorward wind stress of 0.3 dyn cm−2. The monthly mean cur.
Identification of dissolution patterns in nannofossil assemblages: A high‐resolution comparison of synchronous records from Ceara Rise, ODP Leg 154

[1] Fossil nannoplankton assemblages are controlled by both initial plankton production and dissolution throughout the water column and on the seafloor. It is usually assumed that dissolution can be identified by subjective visual assessment of preservation state. We have tested this by a quantitative comparison of mid-Pliocene nannofossil assemblages in two closely located ODP sites, Ceara Rise Sites 926 and 929, both with apparently good preservation but located respectively above and below the lysocline. We demonstrate that, despite an absence of obvious qualitative preservation differences, dissolution has removed perhaps 80% of the assemblage in the sub-lysocline Site 929. This has produced consistent distortions in the assemblages and artificially enhanced abundance variations patterns of individual species. The results provide strong cautions for palaeoceanographic interpretation of nannofossil data and allow us to uniquely extract a dissolution variation record and provide a detailed ranking of dissolution susceptibility of Pliocene nannofossils.
Correction to “An accuracy assessment of the fan wavelet coherence method for elastic thickness estimation”

Kirby, J. F. , and C. J. Swain (2008), An accuracy assessment of the fan wavelet coherence method for elastic thickness estimation, Geochem. Geophys. Geosyst. , 9, Q03022, doi:10.1029/ 2007GC001773. Simons, F. J. (2002), Structure and evolution of the Australian continent: Insights from seismic and mechanical heterogeneity and anisotropy, Ph.D. thesis, 261 pp., Mass. Inst. of Technol. , Boston, Mass. Simons, F. J., and R. D. van der Hilst (2003), Seismic and mechanical anisotropy and the past and present deformation of the Australian lithosphere, Earth Planet. Sci. Lett. , 211, 271–286. G Geochemistry Geophysics Geosystems
Gastronomy as a key factor in branding Spain

Spain has become a name in the world of gastronomy. However, in the global all-out war for gastronomic influence, there are still many challenges for Spain including the need to: improve the gastronomic offer; globally create a brand image; increase Spanish restaurants abroad; develop the tapas concept; become a global reference point for culinary education; and provide tools for travellers to design their experiences and to connect with them (emphasising quality, authenticity, value, substance and comfort). Mass-customisation is becoming a new trend and with this new challenges are unfolding for the food tourism sector.
Determinants of Intention to Purchase a Controversial Halal Cosmetic: The Role of Perceived Expertise

This study investigates the link between perceived expertise, perceived risk, attitude, and purchase intention regarding a controversial halal cosmetic product. This study collected data from 128 Muslim participants who follow influencers discussing potential risks of a specific halal cosmetic brand on Instagram. A PLS-SEM approach was used to analyze the research model. This study revealed that perceived expertise and attitudes have a significant impact on the intention to purchase a controversial halal cosmetic. Interestingly, this study observed no significant connection between perceived risk and attitude or purchase intention. This suggests that when it comes to buying controversial halal cosmetics, consumers may not view perceived risk as a crucial factor. Instead, they seem to be more influenced by expert opinions. This study adds to the existing literature by exploring factors that influence the intention to purchase controversial halal cosmetics.
Drainage network expansion of the Salagou drainage basin (S. France): an example of relief response to recent climate change?

Continental erosion is known to be strongly controlled by climate but the way by which geomorphological systems respond to climate change still remains poorly understood. Recent numerical modelling suggests that drainage networks are subjected to strong spatial fluctuations but few studies of natural systems have addressed this phenomenon because of the difficulty of documenting the evolution of erosional landscapes. A detailed field analysis has allowed reconstruction of the past topography of a drainage basin located in southern France where remnants of a past landscape are well preserved. A change from a smooth to a present‐day dissected landscape is observed and related to a change in the dominant processes of erosion. This evolution is interpreted in terms of fluctuations in drainage network extent in response to a Holocene increase in precipitation.
The indirect aerosol effect over Europe

In order to assess the influence of anthropogenic emissions on cloud albedo over Europe a reprocessed set of satellite measurements from 1985 to 1999 was investigated. Special emphasis was given to the Central European main emission area, including the so‐called ‘Black Triangle’ which covered parts of Germany, the Czech Republic and Poland. Due to the decrease of aerosol precursor gases the analysis reveals a pronounced decrease of cloud albedo of about 2% from the late 80s to the late 90s. During winter in source regions of anthropogenic particulate matter emissions the cloud reflectance is more than 5% lower referring in addition to an absorption effect caused by black carbon in clouds. The comparison with emission data as well as model results of long range transport over Europe strongly supports the conclusion that the changed indirect aerosol effect is responsible for significantly changed cloud optical properties. Radiative transfer calculations indicate for the classical Twomey effect a change in radiative forcing of about 1.5 W/m2 from the late 80s to the late 90s. In addition during winter a radiative forcing of about 3 W/m2 due to the absorption effect for both the late 80s and the late 90s is estimated.
Seasonal dependence of energetic electron precipitation: Evidence for a global role of lightning

Analysis of the DEMETER spacecraft particle data shows that energetic electron precipitation exhibits a seasonal dependence consistent with lighting‐induced electron precipitation (LEP). Over the United States, energetic electron fluxes in the slot region (between L = 2 and 3) are significantly higher in the northern summer than in the winter, consistent with the seasonal variation of lightning activity in the Northern Hemisphere. The association of precipitating fluxes with lightning is explored using lightning location data from the National Lightning Detection Network (NLDN) and VLF wave data on DEMETER. The increased precipitation of particles into the drift loss cone over the Northern Hemisphere in summer is consistent with expected pitch‐angle scattering by lightning‐generated whistler waves, indicating that lightning is a significant contributor to the loss of slot region electrons.
PENGARUH SEKTOR PARIWISATA TERHADAP PDB NEGARA – NEGARA ASEAN PERIODE 2000 – 2010

Penelitian ini bertujuan untuk mengetahui pengaruh penerimaan dari turis internasional terhadap PDB pada negara – negara anggota ASEAN. Selain itu, dilakukan juga beberapa pengelompokkan negara-negara ASEAN berdasarkan 3 kriteria, yakni jumlah penduduk, pendapatan nasional, dan penanaman modal asing. Pengelompokan ini dilakukan untuk mendapatkan hasil yang lebih detail terkait pengaruh penerimaan dari turis internasional terhadap PDB. Penelitian ini menggunakan pendekatan kuantitatif dan metode regresi data pooling. Penelitian ini menggunakan sampel dari 9 negara di ASEAN dalam periode tahun 2000 hingga 2010. Temuan dari penelitian ini menunjukkan bahwa secara rata – rata terdapat pengaruh positif penerimaan dari turis internasional terhadap PDB. Temuan ini sejalan dengan mendukung teori Tourism-led Growth, yang menyatakan bahwa sektor pariwisata (penerimaan dari turis internasional) turut menjadi faktor penentu dalam pertumbuhan ekonomi jangka panjang.
An Ultra-Low Bending Loss Negative Curvature Hollow Core Fiber With a Polygon Jacketing Layer

We design and simulate a new type of hollow-core antiresonant fiber with the polygon jacketing layer. Through numerical calculations, the confinement loss is approximately 0.003 dB/km at 1.45 μm and the bandwidth is ∼ 410 nm @ CL < 0.1 dB/km. We found that more nested tubes can be connected to the jacketing layer to avoid the generation of more cladding nodes. The nested tube cladding with the small size of air holes can effectively suppress the coupling between the fiber cladding and core modes even at extreme bending conditions. Ultra-low bending loss is achieved, and the bending loss is lower than ∼ 0.05 dB/km @ bend radius Rb = 3 cm at 1.50 μm.
For a Cup of Water on Mars: Gusev Crater

Though liquid water is not stable on the surface of Mars today, there are hints in the martian landscape that water once flowed there, eroding valleys and depositing sediments. Understanding where water is, or was, on Mars is a crucial step in looking for life on this smaller, cooler neighbor of Earth. Satellite images, beginning in the early 1970s with Mariner 9 up to the current Mars Global Surveyor, have given us increasingly detailed looks at the surface of Mars, including those intriguing channels that resemble dry river valleys.