Miracle-dz/UniFAR-FTUs huggingface dataset:
Silica‐based organic‐inorganic hybrid nanoparticles and nanoconjugates for improved anticancer drug delivery

After the introduction of first generation MSNs for drug delivery with some challenges such as large particle sizes, irregular morphologies and aggregations, second generation provided uniform spherical morphologies, tunable pore/particle sizes and compositions. Henceforth, organic‐inorganic hybrid mesoporous silica nanosystems have grown rapidly and utilized for active and passive targeting of tumorigenic cells especially conjugated with organic polymers followed by third generation counterparts with improved functionalities for cancer therapy. The aim of this review article is to focus on the advancements in mesoporous silica based organic‐inorganic hybrid nanoparticles developed as drug carriers targeting cancer cells. Brief introduction to the state‐of‐the‐art in passive and active targeting methods is presented. Specifically, therapeutic, diagnostic and theranostic applications are discussed with emphases on triggered and ligand conjugated organic‐inorganic hybrid mesoporous silica nanomaterials. Although mesoporous silica nanoparticles perform well in preclinical tests, clinical translation progresses slowly as appropriate doses needs to be evaluated for human use along with biocompatibility and efficiency depending on surface modifications.
Degenerative knee osteoarthritis animal model and changes in intraosseous pressure during pathological processes

Background Degenerative knee osteoarthritis (KOA) is a common clinical disease which affecting patients' quality of life. However, there is currently no standard animal model for KOA research. The purpose of this study was to find a reasonable age range of animal model for the studying of KOA pathological process, and to investigate Intraosseous pressure (IOP) in the process during different degeneration stages of KOA. Methods Male Dunkin-Hartley guinea pigs were selected and divided into groups of 3, 6, 9, 12, 18 months old by age, 10 in each group. All knees underwent imaging examination including X-ray, Micro CT and MRI. Observed the imaging findings with the use of Kellgren-Lawrence (K-L) classification and knee osteoarthritis MRI scores. Measured the IOP of distal femur and proximal tibia in each group, and observed the differences of bilateral tibiofemoral articular cartilage in histological and immunohistochemistry, staining results were evaluated by using Mankin’s score. Using one-way ANOVA and T-test were used to compare the differences indicators between groups. Results With the increase of age, changes in X-ray, Micro-CT and MRI imaging findings and pathological staining results of articular cartilage in all stages were consistent with the changing of degenerative KOA process. The IOP of distal femur and proximal tibia increased gradually with age, and reached its peak in 12-month age group, and then gradually decreased, there was a statistically significant difference of IOP between each group (femur side: F=8.261, P=0.000; tibial side: F=8.469, P=0.000). The IOP of the distal femur was slightly higher than that of proximal tibia, but the difference was not statistically significant (P>0.05). Conclusions Dunkin-Hartley guinea pig can be used as an animal model to study different pathological stages of KOA. And there might be a correlation between the changes of IOP and the pathological progress of articular cartilage and subchondral bone in distal femur and proximal tibia.
Getting Essential Oil Mixtures by Different Methods and Determination of Their Compositions

Objective: The aim of the study is to determine the enhancement of the essential oil potential and find a more effective method with fewer substances. Materials and Methods: For this purpose, Laurel and fennel essential oils obtained by the method of hydrodistillation in clevenger and their mixtures obtained by 2 different methods (Mix 1: separately obtained and mixed in appropriate proportions and Mix 2: obtained by placing together in the same glass flask) analyzed by Gc/Ms. Results: When the main components of the Mix-1 mixture are examined, the main components of R 3/4 D 1/4 , R 1/2 D 1/2 and R 1/4 D 3/4 combinations are trans-anethhole (54.53%, 32.47% and 17.46%, respectively) and 1.8- cineol (18.16%, 33.11% and 39.37%, respectively). In the second method (Mix-2), the main components of essential oils were examined. The main components of R 3/4 D 1/4 , 1/2
Digital transformation in art pedagogical training in Vietnam today

E-learning is one of the non-traditional education forms and sustainable innovations that can spread knowledge across space, time, and borders worldwide. The article highlights the role, importance, and impact of digital transformation in the field of arts in general and particularly art pedagogical training in Vietnam today. In addition, the article mentions and analyzes the changes among universities, lecturers in terms of art teaching methods and art pedagogical training… during the process of digital transformation. Given the unique features of art pedagogy, a digital transformation model is proposed to shape and develop digital transformation strategies, which hopefully helps to digitize the learner’s experience with digital teaching and learning activities; as well as the environment and mode of operation and training facilities. The model may offer a digital solution to practical problems in art pedagogical training among related training institutions in Vietnam nowadays.
Mental Health Stigma Among Black Immigrant Women in An Urban Setting

Background: Mental health stigma results in unmet mental health needs. Research describing predictors of stigma remains limited among Black immigrants. We aim to examine stigma associated with mental illness among a group of Black immigrant women. Methods: We examined data from 22 women from two Black immigrant community centers. We collected surveys on demographics, cultural beliefs, migration status, religiosity and mental health stigma. Simple linear regression was used to model the unadjusted association between each component variable and overall stigma scores. All analyses were conducted using R and assumed a two-sided, 5% level of significance. Results: A linear relationship was found between author-generated scale, the Stigma and Culture Survey (SCS) and the Depression Self Stigma Scale (DSSS). Among respondents, use of religious resources was associated with less stigma (p-value: 0.04). Whereas spirituality and morality was associated with greater stigma (p-value: 0.003). United States citizenship was associated with less stigma (p-value: 0.0001). Discussion/Conclusion: Religion and spirituality are critical to understanding mental health stigma among Black immigrants. Studies aimed at assessing and reducing stigma need to critically engage with cultural and religious factors.
Love is Not Colorblind: An Investigation of the Racial Hierarchy of Mate Preferences

Not my type is the usual invocation when rejecting potential lovers who don’t align with the racial hierarchy of mating preferences. The largely unchallenged norm of interracial intimacy aversion, particularly how the desire for some racial groups and rejection of others reinforces existing racial inequities, is inconsistent with the blanket notion of greater interracial acceptance. We contend that this acceptance is unequally divided along the same racial hierarchy that exists in the broader public sphere. Our investigation assessed the openness of monoracial and biracial individuals to form interracial romantic relationships. In addition, we partially replicated an interracial mate preference known as the Multiracial Dividend Effect: a pattern whereby monoracial individuals prefer to date multiracial individuals as these interracial relationships may be less likely to carry the perceived disadvantages of interracially dating someone from another monoracial group. Most monoracial groups equally preferred same-race lovers and interracially dating biracials, and they preferred interracially dating someone biracial over any monoracial group. Lastly, biracials were more open to interracially dating any monoracial group than monoracials were to interracially dating each other.
Studi Interaksi antara Segmen Dimer Kitosan dengan Peptida Ac-CA-NH2 dan Ac-TP-NH2 secara Komputasi Ab-Initio

Salah satu faktor yang mempengaruhi sistem drug delivery dengan kitosan adalah kekuatan binding antara kitosan dengan ADTC1. Interaksi antara molekul kitosan dengan ADTC1 adalah melalui gugus –OH dan –NH 2 pada monomer kitosan dengan gugus –Ac dan –NH 2 pada monomer asam amino A, C, T, dan P pada peptida ADTC1. Telah dipelajari interaksi antara molekul Ac-CA-NH 2 dan Ac-TP-NH 2 penyusun peptida ADTC1 (Ac-CADTPPVC-NH 2 ) dengan dimer kitosan. Konfigurasi interaksi yang lebih disukai atau lebih stabil dapat diperkirakan melalui interaksi komponen penyusun kitosan dan komponen penyusun peptida ADTC1 tersebut. Penelitian dibatasi pada dimer kitosan dan peptida Ac-CA-NH 2 dan Ac-TP-NH 2 . Tujuan penelitian adalah untuk menentukan energi interaksi antara peptida Ac-CA-NH 2 dan Ac-TP-NH 2 dengan segmen dimer kitosan. Penelitian dilakukan dengan metode kuantum ab initio pada tingkat teori dan basis set HF/6-31 G(d,p). Hasilnya adalah energi interaksi konfigurasi-1 dan konfigurasi-2 antara dimer kitosan dengan peptida Ac-CA-NH 2 masing-masing adalah -26,144 kJ mol -1 dan -66,5296 kJ mol -1 dengan panjang ikatan-H yang terbentuk rata-rata 2,010 Ǻ. Sedangkan energi interaksi konfigurasi-1 dan konfigurasi-2 antara dimer kitosan dengan peptida Ac-TP-NH 2 masing-masingadalah sebesar -41,5616 kJ mol -1 dan -54,7272 kJ mol -1 dengan panjang ikatan-H yang terbentuk rata-rata 2,053 Ǻ. Kesimpulannya adalah energi interaksi cukup besar sehingga kitosan dapat menjadi sistem delivery bagi ADTC1, dan terdapat berbagai konfigurasi dengan energi interaksi yang berbeda yang diduga sebagai dasar pelepasan secara berkala peptida ADTC1 pada sistem delivery matrik kitosan.
Rheological Behavior of Water-Ethylene Glycol Based Graphene Oxide Nanofluids

Traditionally water-ethylene glycol mixture based nanofluids are used in cold regions as a coolant in the car radiators. In the present study, the rheological properties of water-ethylene glycol based graphene oxide nanofluid are studied using Non-Equilibrium Molecular Dynamics (NEMD) method at different temperatures, volume concentrations, and shear rates. NEMD simulations are performed with considering 75/25, 60/40, and 40/60 ratios of water/ethylene glycol as the base fluids at volume concentrations of 3%, 4%, and 5% graphene oxide nanosheets. The results, which demonstrated good agreement with experimental data, show that the viscosity and density of base fluids significantly decrease with temperature and increases with ethylene glycol volume fraction. Also, the viscosity and density of nanofluids depends directly on the volume concentrations of nanoparticles and decreases with increasing temperature. For example, at 289.85 K, the viscosity of water (75%)-ethylene glycol (25%) based nanofluids containing 3%, 4% and 5% volume concentrations of nanoparticles increased by 33%, 43%, and 56%, respectively. Similarly, the density of the same nanofluids increased by 1%, 1.7 %, and 2.2%, respectively. Moreover, the theoretical models confirm the obtained results. According to the shear rate analysis, the water-ethylene glycol based graphene oxide nanofluid behaves as a non-Newtonian fluid.
The effect of using different types of nanoparticles on optimal design of fin and tube heat exchanger

Application of different types of nanoparticles including Al2O3, SiO2, and CuO is studied to find the effects of nanoparticles on the thermoeconomic optimization of a fin and tube heat exchanger. The effectiveness and the total annual cost are considered as objective functions, and optimization is performed using multi-objective particle swarm optimization algorithm by selection of nine design parameters including nanoparticle volumetric concentration and parameters related to the heat exchanger geometry. The effect of nanoparticles on total annual cost (TAC) vs effectiveness indicates that TAC increases by increase of effectiveness. The results also reveal that in all the studied cases, thermoeconomic improvement is found in the case of nanoparticle additive compared with the base fluid for the high heat exchanger effectiveness. Moreover, application of Al2O3 and CuO is more beneficial than SiO2 in the aspect of thermoeconomic point of view. Furthermore, Al2O3 causes a higher effectiveness in the case of considering nanoparticle price, while in the case of neglecting nanoparticle price, CuO is the best for the higher effectiveness. © 2017 Curtin University and John Wiley & Sons, Ltd.
Designing Studies and Evaluating Research Results: Type M and Type S Errors for Pearson Correlation Coefficient

It is widely appreciated that many studies in psychological science suffer from low statistical power. One of the consequences of analyzing underpowered studies with thresholds of statistical significance, is a high risk of finding exaggerated effect size estimates, in the right or in the wrong direction. These inferential risks can be directly quantified in terms of Type M (magnitude) error and Type S (sign) error, which directly communicate the consequences of design choices on effect size estimation. Given a study design, Type M error is the factor by which a statistically significant effect is on average exaggerated. Type S error is the probability to find a statistically significant result in the opposite direction to the plausible one. Ideally, these errors should be considered during a prospective design analysis in the design phase of a study to determine the appropriate sample size. However, they can also be considered when evaluating studies’ results in a retrospective design analysis. In the present contribution we aim to facilitate the considerations of these errors in the research practice in psychology. For this reason we illustrate how to consider Type M and Type S errors in a design analysis using one of the most common effect size measures in psychology: Pearson correlation coefficient. We provide various examples and make the R functions freely available to enable researchers to perform design analysis for their research projects.
Anxiety, depression and social support in Chinese pregnant women with a history of recurrent miscarriage: a prospective study

Background: Women with a history of recurrent miscarriage(RM) are a more vulnerable population, caring for the pregnant women with a history of RM is quite needed. Although evidence suggests an association among anxiety, depression and social support. Yet, it is unclear about changes in and relationships between anxiety, depression and social support among the pregnant women with a history of RM throughout the pregnancy period. The aim of this study was to examine the changes in and relationships among anxiety, depression and social support across three trimesters of pregnancy in Chinese women with a history of RM. Methods: A prospective, longitudinal study was employed. The study was carried out between September 2016 and October 2017 in a teaching hospital in Guangzhou, China. A convenience sample of 166 pregnant women with a history of RM completed the measures at their 6-12, 20-24 and 32-36 gestational weeks. data were collected by a master student with Zung Self-Rating Anxiety Scale, the Edinburgh Postnatal Depression Scale, and the Perceived Social Support Scale. Results: Anxiety decreased from the early pregnancy to late pregnancy while depression first declined from early pregnancy to mid-pregnancy then remained to late pregnancy. Social support increased from early pregnancy to mid-pregnancy and then remained to late pregnancy. There were correlations in anxiety, depression and social support across the three trimesters of pregnancy. Conclusions: Anxiety and depression are highly prevalent in pregnant women with a history of RM, especially in early pregnancy, which merits clinical attention. Social support was an important buffer against anxiety and depression across the pregnancy. Interventions targeting women with RM may improve the health outcomes of women and their children.
N-hydroxylsulphonamide derivatives as novel physiologically useful nitroxyl donors

FIELD: chemistry. SUBSTANCE: invention relates to N-hydroxylsulphonamide derivatives of formula or , where R 1 is H; R 2 is H; n is 0; b is an integer in the range of 1-4; R 3 , R 4 , R 5 , R 6 and R 7 are independently selected from H, halogen, carboxyl, carboxyl ester selected from a group including -C(O)O-morpholino, -C(O)O-C 1 -C 8 alkyl and -C(O)O-substituted C 1 -C 8 alkyl, where the substitute is morpholino; acylamino, which is a -C(O)NR a R b group, where R a and R b are independently C 1 -C 8 alkyl, or R a and R b together with a nitrogen atom to which they are bonded form morpholino; and sulphonylamino, which is a SO 2 NR 2 group, where two groups R, together with a nitrogen atom to which they are bonded, form morpholino; R 8 is selected from halogen and carbonylamino, selected from a -CONH-substituted C 1 -C 8 alkyl, where the substitute is morpholino; and -CONR 2 , where two groups R, together with a nitrogen atom to which they are bonded, form morpholino; C is a heteroaromatic ring which contains cyclic fragments Q 9 , Q 10 , Q 11 , Q 12 , Q 13 and Q 14 , which are independently selected from C, CH and S, under the condition that at least one of the fragments Q 9 , Q 10 , Q 11 , Q 12 , Q 13 and Q 14 is S. The invention also relates to a method of modulating nitroxyl levels, a method of treating diseases which respond to treatment with nitroxyl, a treatment set and a pharmaceutical composition containing compounds of formula (I) or (III). EFFECT: compounds of formula (I) or (III) for treating diseases which respond to treatment with nitroxyl. 20 cl, 5 ex, 4 tbl, 7 ex
Risk Factors for Depression in Hospitalized Elderly Patients with Malnutrition

Background: There is a lack of information about the factors that affect depression in hospitalized geriatric patients with malnutrition. We aimed to determine the risk and influencing factors of depression in these patients. Methods: The prospective, descriptive study was conducted on 125 elderly patients with malnutrition in Istanbul, Turkey in 2018. The Mini Nutritional Assessment-short form was used in determining the nutritional statuses of the participants, and the Geriatric Depression Scale-short form was used for the status of depression. Results: A negative relationship was found between nutritional status and risk of depression in the study (p: 0.000; r: -0.558). Depression was detected in 52.8% of the patients. 60.8% were women and 39.2% were men. It was also found that BMI scores, gender, marital status, level of education, lifestyle and location, the existence of chronic diseases, chronic medication use, hospital stay period, and mobilization affect the emergence and severity of depression in geriatric patients (p ＜ 0.005). Multivariate regression analysis showed that increased risk of depression occurs with female gender (OR: 24.665, 95% CI: 5.83-104.34), marital status (OR = 11.97, 95% CI: 3.51-40.86), mobilization (OR: 9.52, 95% CI: 1.79-50.71) and malnutrition (OR = 0.49, 95% CI: 0.27-0.89). Conclusions: Depression was frequent in elderly patients with malnutrition. Also, many factors (e.g. low BMI, female gender, mobilization etc.) affect it in hospital. Therefore, close follow-up of patients is important.
The Profile of Pharmacological Treatment in Trigeminal Neuralgia Patients in The Period of January 2018-December 2018

Trigeminal neuralgia is a condition that affects the trigeminal nerve, that manifests in a series of stabbing like pain, and often described like electricity. Its treatment guideline is to prioritize pharmacotherapy until patient is well. The gold standard treatment for trigeminal neuralgia is pharmacotherapy of Carbamazepine. However, carbamazepine is proven to cause allergic reaction to some patients. This research aims to describe the pharmacotherapy that is given to patients. Result: The regiments of pharmacotherapy in trigeminal neuralgia shows that CBZ is the main pharmacotherapy given, as it is the gold standard treatment. GBP is the is the second most pharmacotherapy given, most patients who are given GBP are not able to be given CBZ due to allergic reasons. PDA, a combination therapy of Paracetamol, Diazepam and Amitriptyline is the third most used in trigeminal neuralgia patients. PDA is also added caffeine in certain cases and becomes PDAC, as well as Paracetamol being changed to Ibuprofen and becomes IDA. Other analgesics are only given to one patient. Apart from the main therapy, multiple types of vitamin B is given; Vitaimin B1, B6, B12, Vitamin B Complex and Mecobalamin. 13 patients have complete NRS pain scale, 2 of which did not fully recover to NRS2 0. The use of pharmacotherapy in the treatment of trigeminal neuralgia varies in patients, including other supporting drug for high blood pressure and other complaints. Polytherapy is also used in the treatment such as CBZ+GBP. Although CBZ is the gold standard medication, some patients with CBZ is still feel pain after medication, and other medication shows evidence to be efficacious compared to gold standard CBZ. In conclusion, the medication of trigeminal neuralgia are mostly successful, with patients NRS1 and NRS2 showing significant difference. Most patients recover to not feeling pain. The pharmacotherapy of trigeminal neuralgia is not limited to the use of AEDs and other drug with neurologic pain relieve, but the role of neurotropic b vitamins are important.
The effect of boron concentration on the structure and elastic properties of Ru-Ir alloys: first-principles calculations

The Phase stability, electronic structure, elastic properties and hardness of Ru-Ir alloys with different B concentration were investigated by first principles calculations. The calculated formation enthaplies and cohesive energies show that these compounds are all thermodynamically stable. Information on electronic structure indicates that they possess metallic characteristic and Ru-Ir-B alloys were composed of the Ru-B and Ir-B covalent bond. The elastic properties were calculated, which included bulk modulus, shear modulus, Young’s modulus, Poisson’s ratio and hardness. The calculated results reveal that the plastic of Ru-Ir-B alloys increase with the increase of the content of B atoms, but the hardness of Ru-Ir-B alloys have no substantial progress with the increase of the content of B atoms. However, it is interesting that the hardness of the Ru-Ir-B compound was improved obviously as the B content was higher than 18 atoms because of a phase structure transition.
Posted work: informality and social regulation

Posting represents a growing dimension of intra-European mobility. This ebook proposes an analysis of posted work, based on transnational research conducted with Portuguese workers in the construction sector in France. Inspired by Reynaud’s theory of social regulation, the approach adopted considers posted work as a social system, opposed to traditional industrial relations. The result of the regulation process shows a shift from migration to mobility characterized by poor working conditions and unofficial negotiations and agreements. But posting cannot be considered as “informal” employment. Posting creates its own rules that need to be considered as much as legal elements in order to understand the growing trend and the use of these workers.