Miracle-dz/UniFAR-FTUs huggingface dataset:
Training-Induced Muscle Adaptations During Competitive Preparation in Elite Female Rowers

Training-induced adaptations in muscle morphology, including their magnitude and individual variation, remain relatively unknown in elite athletes. We reported changes in rowing performance and muscle morphology during the general and competitive preparation phases in elite rowers. Nineteen female rowers completed 8 weeks of general preparation, including concurrent endurance and high-load resistance training (HLRT). Seven rowers were monitored during a subsequent 16 weeks of competitive preparation, including concurrent endurance and resistance training with additional plyometric loading (APL). Vastus lateralis muscle volume, physiological cross-sectional area (PCSA), fascicle length, and pennation angle were measured using 3D ultrasonography. Rowing ergometer power output was measured as mean power in the final 4 minutes of an incremental test. Rowing ergometer power output improved during general preparation [+2 ± 2%, effect size (ES) = 0.22, P = 0.004], while fascicle length decreased (−5 ± 8%, ES = −0.47, P = 0.020). Rowing power output further improved during competitive preparation (+5 ± 3%, ES = 0.52, P = 0.010). Here, morphological adaptations were not significant, but demonstrated large ESs for fascicle length (+13 ± 19%, ES = 0.93), medium for pennation angle (−9 ± 15%, ES = −0.71), and small for muscle volume (+8 ± 13%, ES = 0.32). Importantly, rowers showed large individual differences in their training-induced muscle adaptations. In conclusion, vastus lateralis muscles of elite female athletes are highly adaptive to specific training stimuli, and adaptations largely differ between individual athletes. Therefore, coaches are encouraged to closely monitor their athletes' individual (muscle) adaptations to better evaluate the effectiveness of their training programs and finetune them to the athlete's individual needs.
Risk Assessment of RYR Food Supplements: Perception vs. Reality

Thirty-seven red yeast rice (RYR) food supplements were screened for their mycotoxin and natural statin content. Products included pure RYR capsules and multi-ingredient formulations with standardized amounts of monacolin K (MK), marketed both online and retail in the European Union. In terms of mycotoxins, citrinin (CIT) was found in all the monitored products. As CIT content ranged from 100 to 25100 μg/kg, only four products were compliant with maximum EU levels in force until April 2020, while a single product was compliant with the limit of 100 μg/kg introduced after that date. Four contaminated products were labeled as “citrinin free”. In terms of natural statins, nine products had a lower content vs. label statements (from −30 to −83%), while for 24 a larger MK amount (from 10 to 266%) was noticed. Three products had a negligible MK content and only 19 offered a daily dosage exceeding 10 mg as dictated by the health claim granted by EFSA in the EU. No sample had label values compliant with pharmaceutical Good Manufacturing Practices requirements (95–105% content of active constituent). Variable, but small amounts of simvastatin (0.1–7.5 μg per daily dose) were found in 30 samples. These results suggest that limited efficacy and reported safety issues may stem from an under-regulated and undercontrolled market, weakening both effectiveness and risk assessment evaluations.
Applying EVM to Satellite on Ground and In-Orbit Testing - Better Data in Less Time

Using Error Vector Magnitude (EVM) in satellite integration and test allows rapid verification of the Bit Error Rate (BER) performance of a satellite link and is particularly well suited to measurement of low bit rate satellite links where it can result in a major reduction in test time (about 3 weeks per satellite for the Geosynchronous Operational Environmental Satellite [GOES] satellites during ground test) and can provide diagnostic information. Empirical techniques developed to predict BER performance from EVM measurements and lessons learned about applying these techniques during GOES N, O, and P integration test and post launch testing, are discussed.
Retrospektive Bestimmung der elektromagnetischen Exposition durch analoge Rundfunksender im Rahmen von KiSS

Abstract. Im Rahmen einer epidemiologischen Fall-Kontroll-Studie zur Untersuchung eines moglichen Zusammenhangs zwischen der Haufigkeit kindlicher Leukamien und elektromagnetischer Strahlung (,,KiSS" – Kindliche Leukamien und Expositionen in der Umgebung von hochfrequenten Sendestationen) soll die Exposition durch leistungsstarke analoge Rundfunksender retrospektiv (Zeitraum 1982–2003) quantifiziert werden. Die zu betrachtenden Sendernetze fur AM-Horfunk, FM-Horfunk und analoges Fernsehen unterscheiden sich nicht nur hinsichtlich der Modulationsart und der von den Einzelsendern abgestrahlten Leistung, sondern auch in der Netzkonfiguration und den je nach Wellenbereich verschiedenen Strahlungseigenschaften der Sendeantennen. Damit sind bei diesen drei Rundfunkdiensten sowohl die absolute Grose als auch die raumliche Struktur der hervorgerufenen Exposition verschieden. Es wird dargelegt, wie die fur die Prognose der Rundfunkversorgung verwendeten Rechenverfahren zur Modellierung der Feldstarke fur die Modellierung der Exposition herangezogen und durch Kontrollmessungen validiert werden und wie trotz Wahrung der Vertraulichkeit der dabei unabdingbar zu verwendenden Senderbetriebsdaten eine unerwunschte Beeinflussung der Studienergebnisse durch die Senderbetreiber ausgeschlossen wird.
Mode characteristics in a circular uniaxial chiro-omega waveguide

A model for a circular bianisotropic chiro-omega waveguide with perfectly electric wall is suggested. In such a complex guided-wave structure, the transverse field components can be expressed in terms of their longitudinal field components. Numerical results are given to show the dispersion and attenuation characteristics of hybrid modes, and the effects of chirality and omega parameters on the cutoff wavelength of EH/sub 0,1/, HE/sub +or-1,1/ and HE/sub +or-2,1/ modes.
Compact DC-60-GHz HJFET MMIC switches using ohmic electrode-sharing technology

Compact DC-60-GHz heterojunction field-effect transistor (HJFET) monolithic-microwave integrated-circuit (MMIC) switches have been demonstrated for millimeter-wave communications and radar systems. To reduce the MMIC chip size, a novel ohmic electrode-sharing technology (OEST) has been developed for MMIC switches with series-shunt FET configuration. Four FET's of the series-shunt single-pole double-throw (SPDT) MMIC switch were integrated into an area of approximately 0.018 mm/sup 2/. The developed MMIC switches have a high power-handling capability with low insertion loss (IL) and high isolation (Iso) at millimeter-wave frequencies. From DC to 60 GHz, the single-pole single-throw (SPST) MMIC switch achieved the IL and Iso of better than 1.64 and 20.6 dB, respectively. At 40 GHz, the IL increases by 1 dB at the input power of 21 dBm. A novel large-signal FET model for the switch circuit is presented. The simulated power-transfer performance shows the excellent agreement with the measured one. The developed MMIC switches will contribute to the low-cost and high-performance millimeter-wave communications and radar systems.
Microactuators and micromachines

Research and development in microelectromechanical systems (MEMS) have made remarkable progress since 1988, when an electrostatic micromotor the size of a human hair was first operated successfully. Since then, many types of microactuators utilizing various driving forces and mechanisms have been developed. Distinctive features of MEMS (miniaturization, multiplicity of components, and the integration of microelectronics) have led to promising application areas such as fluidic microsystems. In the future, MEMS promises to make contributions to the society of the twenty-first century in three broad areas: (1) offering easier access to information, (2) making human lifestyles more compatible with the environment, and (3) improving people's social welfare. This paper will discuss some of the technological issues pertaining to microactuators, micromachines, and the future development of MEMS.
Isotropic Design of Tendon-Driven Manipulators

This paper deals with the synthesis of mechanical transmission structures for tendon-driven manipulators. Based on static force analysis, necessary conditions are developed for the synthesis of tendon-driven manipulators with isotropic transmission characteristics. It is shown that an n degree-of-freedom (dof) manipulator will possess the isotropic transmission characteristics, if satisfies two isotropic conditions. Furthermore, a design equation is derived for the construction of isotropic transmission structure matrices and a three-dof spatial manipulator is synthesized to demonstrate the methodology. It is shown that the isotropic design leads to a more uniform tendon force distribution.
Receptor Activator of NF-κB (RANK) Confers Resistance to Chemotherapy in AML and Associates with Dismal Disease Course

Simple Summary Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Despite the emergence of new therapeutic agents in recent years, curation remains challenging, and new and better treatment options are needed. In the present study, we investigated the expression, prognostic significance, and functional role of the Receptor Activator of Nuclear Factor-κB (RANK) in AML. We found that RANK is expressed on leukemic cells in a substantial proportion of AML patients and is associated with a dismal disease course. We further demonstrated that signaling via RANK induces release of factors that favor AML cell survival and confers resistance to chemotherapeutics in AML treatment. Together, our findings identify RANK as novel prognostic marker and putative candidate for therapeutic intervention in AML to enhance response to treatment. Abstract Although treatment options of acute myeloid leukemia (AML) have improved over the recent years, prognosis remains poor. Better understanding of the molecular mechanisms influencing and predicting treatment efficacy may improve disease control and outcome. Here we studied the expression, prognostic relevance and functional role of the tumor necrosis factor receptor (TNFR) family member Receptor Activator of Nuclear Factor (NF)-κB (RANK) in AML. We conducted an experimental ex vivo study using leukemic cells of 54 AML patients. Substantial surface expression of RANK was detected on primary AML cells in 35% of the analyzed patients. We further found that RANK signaling induced the release of cytokines acting as growth and survival factors for the leukemic cells and mediated resistance of AML cells to treatment with doxorubicin and cytarabine, the most commonly used cytostatic compounds in AML treatment. In line, RANK expression correlated with a dismal disease course as revealed by reduced overall survival. Together, our results show that RANK plays a yet unrecognized role in AML pathophysiology and resistance to treatment, and identify RANK as “functional” prognostic marker in AML. Therapeutic modulation of RANK holds promise to improve treatment response in AML patients.
Techno-Economic Analysis of Utility-Scale Solar Photovoltaic Plus Battery Power Plant

Decarbonizing the global power sector is a key requirement to fight climate change. Consequently, the deployment of renewable energy (RE) technologies, notably solar photovoltaic (PV), is proceeding rapidly in many regions. However, in many of these regions, the evening peak is predominantly being served by fossil-fired generators. Furthermore, as the evening peak is projected to increase in the coming years, there are plans to install more fossil-fired peaking generators. A cleaner alternative is to enable solar PV plants to provide clean power after sunset by pairing them with large-scale lithium-ion batteries to provide evening peak generation. In this work, we performed a techno-economic analysis of a solar PV plus battery (PVB) power plant using the island of Mauritius as a case study. We assessed the impacts of the battery size, inverter loading ratio (ILR), tracking type, and curtailment on the levelized cost of electricity (LCOE). The main results show that the LCOE of utility-scale PVB systems are comparable to that of fossil-fired peaking generators for this case study. Tracking was shown to exacerbate the clipping loss problem and its benefits on LCOE reduction decrease as the ILR increases. The availability of the PVB system to serve the evening peak was found to be high. The curtailment analysis also showed that planners must not rely solely on storage, but rather should also improve grid flexibility to keep PVB integration affordable. Overall, the practical insights generated will be useful to utility planners in charting their generation expansion strategy.
An Experimental Study on Efficient Piezoelectric Coupled Beams and Corresponding Piezoelectric Bricks

In view of the low output power density of the existing footstep harvesters, two pairs of distinctive L-shaped beams and the corresponding piezoelectric brick models are developed to improve the utilization efficiency of the piezoelectric patches bonded on the beams. A theory model of the aforesaid L-shaped beam is established to analyze its dynamic performance. Two pairs of L-shaped beams and corresponding piezoelectric brick specimens are customized. The influences of some factors on the output voltage and average power from piezoelectric patches of aforesaid piezoelectric bricks are tested and analyzed. Numerical computation based on the theory model of L-shaped beam is conducted to extend the study on the electric output performances of the proposed piezoelectric bricks. Experiment and simulation results indicate that the peak-to-peak voltage and average power can reach up to 376 V (0.15 V/mm3) and 94.72 mW (37.89 μW/mm3) for a piezoelectric patch with a dimension of 50 mm × 50 mm × 1 mm of brick specimens. This research provides novel piezoelectric bricks to harvest footstep energy and obtains some instructive conclusions for the practical design of the piezoelectric brick with ideal energy harvesting efficiency and cost-effectiveness.
Thin-Film PVDF Sensor-Based Monitoring of Cutting Forces in Peripheral End Milling

A sensor module that integrates a thin film polyvinylidene fluoride (PVDF) piezoelectric strain sensor and an in situ data logging platform has been designed and implemented for monitoring of the feed and transverse forces in the peripheral end milling process. The module, which is mounted on the tool shank, measures the dynamic strain(s) produced in the tool and logs the data into an on-board card for later retrieval. The close proximity between the signal source and the PVDF sensor(s) minimizes the attenuation and distortion of the signal along the transmission path and provides high-fidelity signals. It also facilitates the employment of a first principles model based on the Euler–Bernoulli beam theory and constitutive equations of the piezoelectric sensor material to relate the in situ measured PVDF sensor signals to the feed and transverse forces acting on the tool. The PVDF sensor signals are found to compare well with the force signals measured by a platform-type piezoelectric force dynamometer in peripheral end milling experiments.
Shared genetic influences on depression and menopause symptoms

Abstract Background Women experience major depression and post-traumatic stress disorder (PTSD) approximately twice as often as men. Estrogen is thought to contribute to sex differences in these disorders, and reduced estrogen is also known to be a key driver of menopause symptoms such as hot flashes. Moreover, estrogen is used to treat menopause symptoms. In order to test for potential shared genetic influences between menopause symptoms and psychiatric disorders, we conducted a genome-wide association study (GWAS) of estrogen medication use (as a proxy for menopause symptoms) in the UK Biobank. Methods The analysis included 232 993 women aged 39–71 in the UK Biobank. The outcome variable for genetic analyses was estrogen medication use, excluding women using hormonal contraceptives. Trans-ancestry GWAS meta-analyses were conducted along with genetic correlation analyses on the European ancestry GWAS results. Hormone usage was also tested for association with depression and PTSD. Results GWAS of estrogen medication use (compared to non-use) identified a locus in the TACR3 gene, which was previously linked to hot flashes in menopause [top rs77322567, odds ratio (OR) = 0.78, p = 7.7 × 10−15]. Genetic correlation analyses revealed shared genetic influences on menopause symptoms and depression (rg = 0.231, s.e. = 0.055, p = 2.8 × 10−5). Non-genetic analyses revealed higher psychiatric symptoms scores among women using estrogen medications. Conclusions These results suggest that menopause symptoms have a complex genetic etiology which is partially shared with genetic influences on depression. Moreover, the TACR3 gene identified here has direct clinical relevance; antagonists for the neurokinin 3 receptor (coded for by TACR3) are effective treatments for hot flashes.
Kinetics of serum hepcidin and interleukin-6 levels following COVID-19 infection in hemodialysis patients

1AURA Paris Plaisance, Paris, France, 2Institut National de Santé en Recherche Médicale (INSERM) U1149, Centre de recherche sur l’inflammation, Paris, France, 3Centre Français des Porphyries, Hôpital Louis Mourier, Colombes, France, 4HUPNVS UF de biochimie clinique, Hôpitaux Beaujon et Bichat, AP-HP, France, 5AURA Saint-Ouen, Dialyse, Saint-Ouen, France and 6Universite de Toulouse INSERM, CNRS, Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Paul Sabatier (UPS), 31000 Toulouse, France
Inflammatory laboratory findings associated with severe illness among hospitalized individuals with COVID-19 in Medan, Indonesia: a cross-sectional study

Background: Coronavirus disease (COVID-19) remains a global health problem. COVID-19 patients with severe pneumonia have a higher risk for critical illness, mostly complicated by acute respiratory distress syndrome. The inflammatory response is critical, and the cytokine storm increases the severity of COVID-19. Many factors could be associated with a cytokine storm but they are incompletely understood. This study presents characteristics of COVID-19 patients and explore the clinical and inflammatory parameters of severe and critically ill COVID-19 patients in the intensive care unit (ICU). Method: This cross-sectional study was conducted in all severe COVID-19 patients admitted to the ICU. Peripheral blood was taken for laboratory examination within 24 hours of admission. Haematologic parameters, serum electrolyte, renal function, liver function, pancreas enzyme, D-dimer, inflammatory cytokines interferon (IFN)-gamma, tumour necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-10, monocyte chemoattractant protein-1 (MCP-1), and C-reactive protein (CRP) were assessed in this study. Comparative analyses were done between sex, existing comorbidities, body mass index (BMI), and COVID-19 vaccination status. Results: A total of 80 subjects were included in the study. The most frequent comorbidities found among the subjects were obesity (36.35%) and diabetes (22.5%). Only 13.75% of subjects were vaccinated. Laboratory results indicated leucocytosis and neutrophilia, with a neutrophil-lymphocyte-ratio (NLR) of 7. The mean inflammatory findings (IL-6, IL-10, TNF-alpha, IFN-gamma, MCP-1), D-dimer, CRP, and lipase increased. Lipase levels were higher in men (p = 0.003) and in comorbidity groups. No significant differences were found among different BMI groups. Lipase, IL-6, and MCP-1 levels were significantly higher (p=0.019, <0.0001, and 0.03, respectively) in the non-vaccinated group. Conclusions: Most patients with severe COVID-19 have comorbidities and increased inflammatory markers.
Deep Learning Applied to SEM Images for Supporting Marine Coralline Algae Classification

The classification of coralline algae commonly relies on the morphology of cells and reproductive structures, along with thallus organization, observed through Scanning Electron Microscopy (SEM). Nevertheless, species identification based on morphology often leads to uncertainty, due to their general plasticity. Evolutionary and environmental studies featured coralline algae for their ecological significance in both recent and past Oceans and need to rely on robust taxonomy. Research efforts towards new putative diagnostic tools have recently been focused on cell wall ultrastructure. In this work, we explored a new classification tool for coralline algae, using fine-tuning pretrained Convolutional Neural Networks (CNNs) on SEM images paired to morphological categories, including cell wall ultrastructure. We considered four common Mediterranean species, classified at genus and at the species level (Lithothamnion corallioides, Mesophyllum philippii, Lithophyllum racemus, Lithophyllum pseudoracemus). Our model produced promising results in terms of image classification accuracy given the constraint of a limited dataset and was tested for the identification of two ambiguous samples referred to as L. cf. racemus. Overall, explanatory image analyses suggest a high diagnostic value of calcification patterns, which significantly contributed to class predictions. Thus, CNNs proved to be a valid support to the morphological approach to taxonomy in coralline algae.
A Mixture of Lactobacillus fermentum HFY06 and Arabinoxylan Ameliorates Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Mice

Objective Colitis is one of the main gastrointestinal diseases threatening human health. Materials and Methods In this study, a synbiotic composed of arabinoxylan (AX) and Lactobacillus fermentum HFY06 was tested to determine its ability to relieve dextran sulfate sodium (DSS)-induced colitis. Results The experimental results showed that the synergistic effect of AX and L. fermentum HFY06 alleviated the weight loss of DSS-mediated colitis mice and lowered the disease activity index (DAI) score. Determination of biochemical indicators found that the synbiotic composed of AX and L. fermentum HFY06 increased the body’s antioxidant capacity and reduced inflammation. The histopathological examination results showed that the colonic crypts of the mice in the model group were disordered, goblet cells were lost, and the mucous membrane was severely damaged. However, the combination of AX and L. fermentum HFY06 can significantly reverse the histopathological changes in the colon mediated by DSS. The gene expression of colon tissue was further determined, and the results showed that the synergistic effect of AX and L. fermentum HFY06 inhibited the activation of the NF-κB signaling pathway, downregulated the mRNA expression levels of nuclear factor-κB-p65 (NF-κBp65), upregulated the mRNA expression of NF-κB inhibitor-α (IκB-α), inhibited the release of cytokines tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX-2), and exerted anti-colitis effects. Conclusion This study shows that the synbiotic composed of AX and L. fermentum HFY06 has the potential to prevent and treat colitis.