Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effectiveness of Evidence-Based Teaching Practices in Biomedical Sciences on Students’ Learning Experience: A Systematic Literature Review

The traditional didactic approach to teaching in biomedical sciences falls short of providing students with the 21st century competencies necessary to meet the socioeconomic demands placed upon them. Tertiary biomedical science educators have sought empirical evidence to identify the best practices to meet these demands, each of which have an element of actively involving students in their learning, as opposed to passive and didactic instructional approaches. This review synthesises the literature on evidence-based teaching practices (EBTPs) implemented in biomedical science disciplines and investigates the impact of EBTPs on students’ learning experiences through a systematic review. Seventy-eight studies were analysed, providing a comprehensive review of teaching practices that supported active learning in biomedical science disciplines. The findings revealed that EBTPs had significant impact on students’ academic performance and learning experiences to enhance higher-order thinking skills and self-directed learning, despite the variation in educational setting. A range of instructional strategies and technologies that supported active learning experiences were identified in this review, and the findings provide an evidence base to inform pedagogical decisions regarding the implementation of EBTPs and may serve as an impetus for instructors to implement active learning strategies based on this empirical evidence.
Identifying special structures in interval-data via model-based clustering

In this paper we present a model-based approach to the clustering of interval data building on recently proposed parametric models. These methods consider configurations for the variance-covariance matrix that take the nature of the interval data directly into account. The proposed framework relies on parametrizations considering the inherent variability of the relevant data units and the relation that may exist between this variability and the corresponding value levels. Using both synthetic and real data sets the pertinence of the proposed methodology is shown, as the method effectively selects heterocedastic models with restricted covariance structures when they are the most suitable, even in situations with limited information. Moreover, considering special configurations of the variance-covariance matrix, adapted to nature of interval data, proves to be the adequate approach. The presented study also makes clear the need to consider both the information about position (conveyed by the MidPoints) and intrinsic variability (conveyed by the Log-Ranges) when analysing interval data.
Scientific connotation of the compatibility of traditional Chinese medicine from the perspective of the intestinal flora

Revealing the connotation of the compatibility of Chinese medicines (CM) is a requirement for the modernization of traditional Chinese medicine (TCM). However, no consensus exists on the specific mechanism of traditional Chinese medicine compatibility (TCMC). Many studies have shown that the occurrence and development of diseases and the efficacy of CM are closely related to intestinal flora (IF), which may provide a new perspective to understand the theory of TCM. This study aimed to summarize the relationship between the changes in IF before and after the compatibility of different drugs and the synergistic, toxicity reduction, and incompatibility effects of drug pairs from the perspective of the effects of CM on the IF and the regulation of microbial metabolites. These studies showed that the effect of drug pairs on the composition of the IF is not a simple superposition of two single drugs, and that the drug pairs also play a specific role in regulating the production of intestinal bacterial metabolites; therefore, it has a different pharmacodynamic effect, which may provide a perspective to clarify the compatibility mechanism. However, research on the interpretation of the scientific connotations of TCMC from the perspective of the IF is still in its infancy and has limitations. Therefore, this study aimed to summarize previous research experience and proposed to conduct a deep and systematic study from the perspective of drug pair dismantling, IF, intestinal bacteria metabolite, organism, and disease to provide a reference for scientific research on the compatibility mechanism of CM.
Surfaces Family with Bertrand Curves as Common Asymptotic Curves in Euclidean 3-Space E3

The main result of this paper is constructing a surfaces family with the similarity of Bertrand curves in Euclidean 3–space E3. Then, by utilizing the Serret–Frenet frame, we conclude the sufficient and necessary conditions of surfaces family interpolating Bertrand curves as common asymptotic curves. Consequently, the expansion to the ruled surfaces family is also depicted. As implementations of our main results, we demonstrate some examples to confirm the method.
Better Safe Than Sorry: Risk Management Based on a Safety-Augmented Network Intrusion Detection System

Interconnected industrial control system (ICS) networks based on routable protocols are susceptible to remote attacks similar to classical information technology (IT) networks. However, addressing ICS security in an isolated view is dangerous since ICSs have to ensure safety measures for people, processes, and the environment. The safety and security of ICSs are often addressed separately, without considering their important interrelation. Safety measures can violate security policies (e.g., an emergency stop function accessible by anyone); likewise, a security incident can violate safety policies (e.g., by increasing reaction time). In this article, we propose a network-based intrusion detection system with the interrelation between safety and security in mind. It detects security incidents while evaluating possible safety-related consequences of both the detected attack and possible countermeasures. We evaluate our approach with a Proof of Concept (PoC). The alerts generated by the PoC prototype serve as the basis for a risk management strategy proposed in this article. Our approach provides a basis for safety-aware intrusion detection in smart factories and other cyber-physical systems.
Design, Fabrication, and Measurement Study of a Planar Phased Array Antenna

Phased array antenna (PAA) application in mobile communication is increasingly extensive, bringing a wide range of metrology requirements. The rotating-element electric-field vector (REV) method with circle fitting and linear fitting based on the complex measurement is proposed to calibrate the PAA. The simulation verifies the feasibility of the calibration method and the uncertainty contribution of the amplitude and phase fluctuation of the phase shifter to the array calibration and beamforming parameters. An $8\times6$ patch array with a unique digital phase shifter for each element is designed for metrology research. The designed phased array is calibrated and measured in the anechoic chamber, with different initial phases of each element being programmable adjusted. The results show that the adjusted initial phases are calibrated accurately, and the array could be used for beamforming.
Src-Dependent NM2A Tyrosine Phosphorylation Regulates Actomyosin Remodeling

Non-muscle myosin 2A (NM2A) is a key cytoskeletal enzyme that, along with actin, assembles into actomyosin filaments inside cells. NM2A is fundamental for cell adhesion and motility, playing important functions in different stages of development and during the progression of viral and bacterial infections. Phosphorylation events regulate the activity and the cellular localization of NM2A. We previously identified the tyrosine phosphorylation of residue 158 (pTyr158) in the motor domain of the NM2A heavy chain. This phosphorylation can be promoted by Listeria monocytogenes infection of epithelial cells and is dependent on Src kinase; however, its molecular role is unknown. Here, we show that the status of pTyr158 defines cytoskeletal organization, affects the assembly/disassembly of focal adhesions, and interferes with cell migration. Cells overexpressing a non-phosphorylatable NM2A variant or expressing reduced levels of Src kinase display increased stress fibers and larger focal adhesions, suggesting an altered contraction status consistent with the increased NM2A activity that we also observed. We propose NM2A pTyr158 as a novel layer of regulation of actomyosin cytoskeleton organization.
A technique for multitarget tracking in synthetic aperture radar spotlight imaging mode based on promoted PHD filtering approach

This paper investigates a new method based on promoted probability hypothesis density (PHD) filtering to simultaneously track several moving targets in data received by synthetic aperture radar (SAR) in spotlight imaging mode. Simultaneous tracking of several targets in the presence of high‐density clutters in environment, as the particular capability of the PHD filter, has turned it into a robust approach in SAR to track moving targets. Given the PHD filter function as a sequence of prediction and update steps, it is more reasonable to apply the approach to the data received by the SAR in spotlight imaging mode; however, according to the specified system parameters, such method is not impossible to be implemented using the Stripmap imaging mode. According to simulation results, applying Range Cell Migration Compensation to the raw data received by SAR before tracking operation results in high‐quality tracking of moving targets.
Natural Drugs: A New Direction for the Prevention and Treatment of Diabetes

Insulin resistance, as a common pathological process of many metabolic diseases, including diabetes and obesity, has attracted much attention due to its relevant influencing factors. To date, studies have mainly focused on the shared mechanisms between mitochondrial stress and insulin resistance, and they are now being pursued as a very attractive therapeutic target due to their extensive involvement in many human clinical settings. In view of the complex pathogenesis of diabetes, natural drugs have become new players in diabetes prevention and treatment because of their wide targets and few side effects. In particular, plant phenolics have received attention because of their close relationship with oxidative stress. In this review, we briefly review the mechanisms by which mitochondrial stress leads to insulin resistance. Moreover, we list some cytokines and genes that have recently been found to play roles in mitochondrial stress and insulin resistance. Furthermore, we describe several natural drugs that are currently widely used and give a brief overview of their therapeutic mechanisms. Finally, we suggest possible ideas for future research related to the unique role that natural drugs play in the treatment of insulin resistance through the above targets.
Anatomical, morphological and physiological leaf characters of black betel (Piper betle L. var. nigra) in varying natural and man-made habitats

Abstract. Kuswandi PC, Ariyanti NA, Yunus MF, Amri CNAC. 2023. Anatomical, morphological and physiological leaf characters of black betel (Piper betleL. var. nigra) in varying natural and man-made habitats. Biodiversitas 24: 3236-3244. Piper betle L. var. nigra or black betel (known as Sirih hitam in Indonesia) contains valuable secondary metabolites, such as alkaloids, flavonoids, saponins, tannins, phenols, carotenoids, steroids and terpenoids. Black betel leaf extract has been shown to have antimicrobial activity thus there is a prospect to be developed as a promising herbal plant. Nevertheless, little information is available about its development as a medicinal plant. This research studies the influence of different habitats on several characters of black betel leaves with the aim to understand the suitable environmental conditions for the optimum growth of black betel plants. We used a survey method and random sampling of black betel leaves in four locations in Java Island, Indonesia, namely Banyuwangi which represents natural habitat, and Karanganyar, Ngaglik and Pakem which represent man-made habitats. Measurements of temperature, humidity, soil moisture and light intensity were carried out at each location. Analyses of leaf area, leaf water content, total leaf chlorophyll content and flavonoid content were undertaken and statistically analyzed using SPSS software. Leaf transverse sections were also observed. The results showed that the environmental parameters differed in the four locations. Leaves samples from the natural habitat in Banyuwangi were significantly different (P<0.05) from the three man-made habitats for chlorophyll and flavonoid content. For water content, significant difference was only for Banyuwangi samples with those from Karanganyar and Pakem. For leaf area, significant difference was only found between the Banyuwangi samples and Karanganyar. Observations on the transverse cross section of midrib of black betel leaves from the four locations showed structures that are generally found in Piper betle species, namely the presence of an epidermal layer, trichomes in the abaxial part of the leaf, several layers of the hypodermis, visible vascular tissue and the presence of secretion cells. There were several differences in the leaf anatomy such as greater number of trichomes on the leaves from Karanganyar, the secretory cells that were more visible in the leaves from Ngaglik and Banyuwangi and the sclerenchymal tissue that was more visible in the leaves from Banyuwangi. Such differences are likely influenced by variations in environmental parameters thus showing that the man-made habitat in the Karanganyar location can affect leaves characters similar to black betel plant grown in its natural habitat in Banyuwangi.
Development of submerged arc welding flux from rice straw ash

ABSTRACT At present, a large amount of rice straw ash is being dumped as waste creating soil and water pollution. The manufacturing of welding fluxes requires minerals which are mined out from the earth’s crust creating environmental ill effects. This paper presents a novel methodology for utilizing rice straw ash in the manufacturing of submerged arc welding (SAW) fluxes. The chemical composition of the joints produced with the developed flux is well within the acceptable range of American Welding Society (AWS) specifications. Their tensile strength and joint efficiency are 8% and 9% more than the joints produced with a commercial flux respectively. Their bead geometries are comparable to the beads deposited with the commercial flux. The joints are sufficiently ductile and could easily pass the bend test. The weld metal exhibits a desired microstructure containing acicular ferrite. This technology may turn the rice straw ash into a blessing in disguise.
Comparison of Traditional and Advanced Resistance Training Paradigms on Muscle Hypertrophy in Trained Individuals: A Systematic Review and Meta-Analysis

Trained individuals may require variations in training stimuli and advanced resistance training paradigms (ADV) to increase skeletal muscle hypertrophy. However, no meta-analysis has examined how ADV versus traditional (TRAD) approaches may differentially affect hypertrophic outcomes in trained populations. The aim of this review was to determine whether the skeletal muscle hypertrophy responses induced by TRAD differed from ADV in resistance-trained individuals. Furthermore, we sought to examine potential effects of dietary factors, participants’ training status, and training loads. We searched for peer-reviewed, randomized controlled trials (published in English) conducted in healthy resistance-trained adults performing a period of TRAD and ADV with pre-to-post measurement(s) of muscle hypertrophy in PubMed, Web of Science, SPORTDiscus, and MEDLINE databases up to October 2022. A formal meta-analysis was conducted in Revman5, and risk of bias was assessed by ROB2. Ten studies met the inclusion criteria. Results indicated no difference between ADV and TRAD for muscle thickness (SMD = 0.05, 95% CI: −0.20 0.29, p = 0.70), lean mass (SMD = −0.01, 95% CI: −0.26 0.23, p = 0.92), muscle cross-sectional area (SMD = −0.07, 95% CI: −0.36 0.22, p = 0.64), or all measurements analyzed together (SMD = −0.00, 95% CI: −0.15 0.14, p = 0.95). No heterogeneity or inconsistencies were observed; however, unclear risk of bias was present in most of the studies. Short-term ADV does not induce superior skeletal muscle hypertrophy responses when compared with TRAD in trained individuals. This review was not previously registered.
Neurophysiological signatures of sensory-processing sensitivity

Background Sensory processing sensitivity is mainly captured based on questionnaires and it’s neurophysiological basis is largely unknown. As hitherto no electroencephalography (EEG) study has been carried out, the aim of this work was to determine whether the self-reported level of SPS correlates with the EEG activity in different frequency bands. Methods One hundred fifteen participants were measured with 64-channel EEG during a task-free resting state. After artifact correction, a power spectrum time series was calculated using the Fast Fourier Transform (FFT) for the following frequency bands: Delta: 1–3.5 Hz, theta: 4–7.5 Hz, alpha1: 8–10 Hz, alpha2: 10.5–12 Hz, beta1: 12.5–15 Hz, beta2: 15.5–25 Hz, gamma: 25.5–45 Hz, global: 1–45 Hz. Correlations with the ‘Highly Sensitive Person Scale’ (HSPS-G) scores were determined. Then, the lowest and the highest 30% of the cohort were contrasted as polar opposites. EEG features were compared between the two groups applying a paired two-tailed t-test. Results The HSPS-G scores correlated statistically significantly positive with beta 1 and 2, and global EEG power during resting with eyes open, but not during resting with eyes closed. The highly sensitive group revealed higher beta power (4.38 ± 0.32 vs. 4.21 ± 0.17, p = 0.014), higher gamma power (4.21 ± 0.37 vs. 4.00 ± 0.25, p = 0.010), and increased global EEG power (4.38 ± 0.29 vs. 4.25 ± 0.17, p = 0.041). The higher EEG activity in the HSP group was most pronounced in the central, parietal, and temporal region, whereas lower EEG activity was most present in occipital areas. Conclusion For the first time, neurophysiological signatures associated with SPS during a task free resting state were demonstrated. Evidence is provided that neural processes differ between HSP and non-HSP. During resting with eyes open HSP exhibit higher EEG activity suggesting increased information processing. The findings could be of importance for the development of biomarkers for clinical diagnostics and intervention efficacy evaluation.
Homologie des complexes de formes différentielles d'ordre supérieur

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Some solutions to the multivariate Behrens–Fisher problem for dissimilarity‐based analyses

The essence of the generalised multivariate Behrens–Fisher problem (BFP) is how to test the null hypothesis of equality of mean vectors for two or more populations when their dispersion matrices differ. Solutions to the BFP usually assume variables are multivariate normal and do not handle high‐dimensional data. In ecology, species' count data are often high‐dimensional, non‐normal and heterogeneous. Also, interest lies in analysing compositional dissimilarities among whole communities in non‐Euclidean (semi‐metric or non‐metric) multivariate space. Hence, dissimilarity‐based tests by permutation (e.g., PERMANOVA, ANOSIM) are used to detect differences among groups of multivariate samples. Such tests are not robust, however, to heterogeneity of dispersions in the space of the chosen dissimilarity measure, most conspicuously for unbalanced designs. Here, we propose a modification to the PERMANOVA test statistic, coupled with either permutation or bootstrap resampling methods, as a solution to the BFP for dissimilarity‐based tests. Empirical simulations demonstrate that the type I error remains close to nominal significance levels under classical scenarios known to cause problems for the un‐modified test. Furthermore, the permutation approach is found to be more powerful than the (more conservative) bootstrap for detecting changes in community structure for real ecological datasets. The utility of the approach is shown through analysis of 809 species of benthic soft‐sediment invertebrates from 101 sites in five areas spanning 1960 km along the Norwegian continental shelf, based on the Jaccard dissimilarity measure.
All-Detuned Three-Coil Configuration for Advantages in Inductive Power Transfer Systems

In inductive power transfer systems, some applications require working at higher power levels, transferring power with longer air gaps, and meeting geometric constraints. Many situations will decrease system coupling and affect performance. In this article, a three-coil configuration based on an all-detuned design is proposed to optimize the overall coupling and system efficiency. Primary and tertiary coils of the proposed topology are mounted on the same side. The three coil resonances in the proposed system, as extra degrees of freedom, do not match the switching frequency or each other. The key objectives of the proposed all-detuned design are to achieve a constant current output and unity power factor based on an equivalent two-coil circuit model; maximize the overall coupling coefficient to reduce the switching frequency or coil inductances by selecting a suitable tertiary resonant frequency; and optimize efficiency to be superior to those in a conventional two-coil system by minimizing coil currents. A 1-kW prototype has been prepared to verify the method. For example, when the main coupling coefficient is only 0.077, dc–dc efficiency of the proposed method ranges from 90.2% to 91.2% over a 2:1 load range, while that of the conventional two-coil system does not exceed 90%.
Metabolic changes and potential biomarkers in "Candidatus Liberibacter solanacearum"-infected potato psyllids: implications for psyllid-pathogen interactions

Psyllid yellows, vein-greening (VG), and zebra chip (ZC) diseases, which are primarily transmitted by potato psyllid (PoP) carrying Candidatus Liberibacter solanacearum (CLso), have caused significant losses in solanaceous crop production worldwide. Pathogens interact with their vectors at the organic and cellular levels, while the potential changes that may occur at the biochemical level are less well reported. In this study, the impact of CLso on the metabolism of PoP and the identification of biomarkers from infected psyllids were examined. Using ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) analysis, metabolomic changes in CLso-infected psyllids were compared to uninfected ones. A total of 34 metabolites were identified as potential biomarkers of CLso infection, which were primarily related to amino acid, carbohydrate, and lipid metabolism. The significant increase in glycerophospholipids is thought to be associated with CLso evading the insect vector’s immune defense. Matrix-assisted Laser Desorption Ionization Mass Spectrometry Imaging (MALDI-MSI) was used to map the spatial distribution of these biomarkers, revealing that 15-keto-Prostaglandin E2 and alpha-D-Glucose were highly expressed in the abdomen of uninfected psyllids but down-regulated in infected psyllids. It is speculated that this down-regulation may be due to CLso evading surveillance by immune suppression in the PoP midgut. Overall, valuable biochemical information was provided, a theoretical basis for a better understanding of psyllid-pathogen interactions was offered, and the findings may aid in breaking the transmission cycle of these diseases.