Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring Barriers in Health Care Delivery System for Cancer Care in Ethiopia

Background: Though the trouble of cancer is increasing worldwide and recognized as the crucial public health crises, the health care systems have been facing great challenges to improve the care given to cancer. Among total mortality in Ethiopia, cancer takes 5.8%. Considering cancer as the public health priority area in May 2017, world governments decided increase the budget expenditure for cancer control in an integrated approach. As of now the best action to deal with cancer problem is to reduce barriers and to give the feasible quality care as much as possible to all in need in spite of any condition, precondition or geographic location. Methods: qualitative study with in-depth interview by using semi structured tools was conducted in Ethiopia at Black Lion specialized hospital and Ethiopian ministry of health. Study population was cancer patients, health professionals working at Black lion hospital and health experts working at federal ministry of health. Purposive sampling was employed to select study populations. Results: In general financial problems for both direct and indirect cost and geographical accessibility, shortage of investigation facilities, absence of physicians in their offices, long waiting time for getting the result, complicated referral process and lacking of ability among physicians, were explained barriers by study participants in health care for cancer care service utilization. Conclusions: the finding showed that this situation deserves more attention both from health policy decision-makers and private donors to eliminate barriers in health care which would improve the quality of health care delivery system for cancer care.
Packing-constrained point coverings

In the packing-constrained point covering problem, PC^2, one seeks configurations of points in the plane that cannot all be covered by a packing arrangement of unit disks. We consider in particular the problem of finding the minimum number of points N for which such a configuration exists and obtain the bounds 11 <= N <= 55. The disparity of these bounds is symptomatic, we believe, of the fact that PC^2 belongs in a higher complexity class than the standard packing and covering problems.
La comparaison d’un diagnostic tardif de VIH comme marqueur des soins des Autochtones par rapport aux non-Autochtones qui vivent avec le VIH en Ontario

BACkgROuND: Studies have found that Aboriginal people living with HIV/AIDS (APHAs) are more likely than non-APHAs to receive suboptimal HIV care, yet achieve similar clinical outcomes with proper care. OBJeCTIVe: To compare the proportions of individuals diagnosed late with HIV between APHAs and non-APHAs within the Ontario HIV Treatment Network Cohort Study (OCS). MeTHODS: The analysis included OCS participants who completed the baseline visit by November 2009. Two definitions of the outcome of late HIV diagnosis were used: the proportion of participants with an AIDSdefining illness (ADI) before or within three months of HIV diagnosis; and the proportion of participants with a CD4+ count <200 cells/mL at diagnosis. Logistic regression analysis was used to assess the association between Aboriginal ethnicity and late HIV diagnosis. ReSuLTS: APHAs were more likely to be female and have lower income, education and employment. No statistically significant differences were noted in the proportions receiving a late HIV diagnosis defined by ADI (Aboriginal 5.2% versus non-Aboriginal 6.3%; P=0.40). Multivariate logistic regression analysis revealed a significant association between Aboriginal ethnicity and late HIV diagnosis defined by CD4+ count after adjusting for age and HIV risk factor (OR 1.55; P=0.04). DISCuSSION: APHAs were more likely to have a CD4+ count <200 cells/mL at diagnosis but had similar clinical outcomes from late diagnosis when defined by ADI. However, differences may be underestimated due to recruitment limitations and selection bias. CONCLuSION: Additional work is needed to address the socioeconomic and health care needs of APHAs.
Supplementary Data_3.eps

Impaired wound healing is one of the main causes of diabetic foot ulcerations. However, the exact mechanism of delayed wound healing in diabetes is not fully understood. Long noncoding RNAs (lncRNAs) are widely involved in a variety of biological processes and diseases, including diabetes and its associated complications. In this study, we identi ed a novel lncRNA, MRAK052872, named lncRNA UpRegulated in Diabetic Skin (lnc-URIDS), which regulates wound healing in diabetes. lnc-URIDS was highly expressed in diabetic skin and dermal broblasts treated with advanced glycation end products (AGEs). lnc-URIDS knockdown promoted migration of dermal broblasts under AGEs treatment in vitro and accelerated diabetic wound healing in vivo. Mechanistically, lnc-URIDS interacts with procollagenlysine, 2-oxoglutarate 5-dioxygenase 1 (Plod1), a critical enzyme responsible for collagen cross-linking. The binding of lnc-URIDS to Plod1 results in a decreased protein stability of Plod1, which ultimately leads to the dysregulation of collagen production and deposition and delays wound healing. Collectively, this study identi es a novel lncRNA that regulates diabetic wound healing by targeting Plod1. The ndings of the current study offer some insight into the potential mechanism for the delayed wound healing in diabetes and provide a potential therapeutic target for diabetic foot.
Collaborative and EmbeddedKnowledge Boundaries of an ICT Consulting Firm

Knowledge is not embedded in organizations’ boundaries but their collaborative networks cross organizations. The paper indicates knowledge boundaries are formed by their respective social contexts, relationships and practices of networks through participative observing two practice teams of an ICT consulting firm. To emphasis, the teams’ perspectives, knowledge structures, knowledge values, identities, teamwork styles are affected by their knowledge boundaries. The implication of knowledge boundaries on key topics in teams’ knowledge governance, professional service firms’ market entering strategies, and national knowledge innovation issues are discussed. This research provides a new direction to take industry seriously in the knowledge management of IS research.
Topics in particle physics beyond the Standard Model

PAGE We present new models of particle physics beyond the Standard Model. These models include extensions to the ideas of extra dimensions, deconstruction, supersymmetry, and Higgsless electroweak symmetry breaking. Besides introducing new models and discussing their consequences, we also discuss how galaxy cluster surveys can be used to constrain new physics beyond the Standard Model. We find that an ultraviolet completion of gauge theories in the Randall-Sundrum model can be found in a deconstructed theory. The warping of the extra dimension is reproduced in the low energy theory by considering a general potential for the link fields with translational in variance broken only by boundary terms. The mass spectrum for the gauge and link fields is found to deviate from the Randall-Sundrum case after the first couple modes. By extending this model to a supersymmetric theory space, we find that supersymmetry is broken by the generation of a cosmological constant. Unless the theory is coupled to gravity or messenger fields, the spectrum remains supersymmetric. We also present a hybrid Randall-Sundrum model in which an infmite slice of warped space is added to the extra dimension of the original theory. The hybrid model has a continuous gravitational spectrum with resonances at the Kaluza-Klein excitations of the original orbifolded model. A similar model is considered where the infinite space is cutoff by the addition of a negative tension brane. SU(2)L x SU(2)R x U(l )s-L gauge fields are added to the bulk of our hybrid model and we fmd that electro weak symmetry is broken with an appropriate choice of boundary conditions. By varying the size of the extra dimension, we find that the S parameter can be decreased by as much as 60 %. Finally we review models of structure formation and discuss the possibility of constraining new physics with galaxy cluster surveys. We find that for a large scatter in the luminosity-temperature relation, the cosmological parameters favored by galaxy cluster counts from the 400 Square Degree ROSAT survey are in agreement with the values found in the WMAP-3 year analysis. We explain why X-Ray surveys of galaxy cluster number counts are insensitive to new physics that would produce a dimming mechanism. List of Figures . Acknolwedgements CHAPTER TABLE OF CONTENTS
Design of Single Phase Nine Level Inverter for an Unbalanced Capacitor

: This paper presents an effective circuit configuration of a nine level inverter. In this proposed system, the unbalanced capacitor voltage that occur in series connected capacitor will be compensated by connecting resistors in parallel and then by the number of power electronic switches, the output voltage level is improved. The circuit consists of single dc source, series capacitor and eight number of switching devices. This proposed method is very efficient to achieve nine level output voltage and reduction in total harmonic distortion. The experimental results correlate well with simulation and a prototype drive has been built and tested to verify its practical viability.
Vermeidung von Divisionen.

The extent to whieh the use of divisions may speed up the evaluation of polynomials is estimated from above. In particular it is shown that for multiplying general matrices the use of divisions does not decrease the number of (*,/)-operations. The computational complexity of the multiplication of matrices from a linear algebraic group G is estimated from below by a simple algebraic invariant of the Liering of G. In particular, the multiplication of orthogonal matrices is treated.
International Journal of Scientific Research in Computer Science, Engineering and Information Technology

Cloud Computing is inevitability as the number of connected devices are growing and also the computing and storage needs. Cloud computing converts the way Information Technology is encouraged and succeeded, cost worth, faster invention, faster time-to-market, and the capable to measure applications on demand. Security of the cloud is a major challenge today which has to be addressed. Several new technologies are emerging to keep the cloud services secure and efficient at the same time. This paper discusses the cloud services, risk associated with it and security measures in cloud computing.
Space-time Modelling with Long-memory Dependence: Assessing Ireland's Wind Power Resource

SUMMARY We consider estimation of the long term average power output from a wind turbine generator at a site for which few data on wind speeds are available. Long term records of wind speeds at the 12 synoptic meteorological stations are also used. Inference is based on a simple and parsimonious approximating model which accounts for the main features of wind speeds in Ireland, namely seasonal effects, spatial correlation, short-memory temporal autocorrelation and long-memory temporal dependence. It synthesizes deseasonalization, kriging, ARMA modelling and fractional differencing in a natural way. A simple kriging estimator performs well as a point estimator, and good interval estimators result from the model. The resulting procedure is easy to apply in practice. L. Smith (University of Surrey): This paper is an excellent example of the development of statistical methodology to solve a substantial applied problem. The problem is typical of those which arise in what may loosely be termed the environmental sciences -by these I include such fields as hydrology, meteorology, air pollution and numerous problems with a biological flavour. As such, the methods used will be of interest to workers in all these fields. The authors' approach incorporates many techniques. After initial exploratory analysis they propose a 'kriging' estimator for interpolation at a new site, exploiting spatial correlations. Further analysis leads them to identify a model incorporating long-range and short-range temporal correlations. The method of fitting, based on an approximate likelihood function, makes an original contribution to the compu tational aspect of time series models, and finally the model is applied, not without further difficulties, to the prediction of wind power.
Cell Activation Subsets of Human Dendritic Cells Tunes NK Distinctive Lack of CD48 Expression in

CD48 is a glycosyl phosphatidylinositol anchor protein known to be virtually expressed by all human leukocytes. Its ligand, 2B4, is a signaling lymphocyte activation molecule-related receptor involved in NK cell activation. Because dendritic cells (DCs) are strong inducers of NK cell functions, we analyzed the expression of CD48 in different human DC subsets. We observed that monocytes differentiating in DCs promptly down-regulate CD48. Similarly, DCs isolated from inﬂamed lymph nodes generally do not express CD48. Plasmocytoid DCs do not express CD48 either, whereas myeloid DCs harbored in blood, bone marrow, and thymus express it. In addition, we showed that CD48 expression in DCs affects NK cell functions during NK/DC cross-talk, because NK cells obtained from normal donors and from X-linked lymphoproliferative disease patients are, respectively, triggered or inhibited by DCs expressing surface CD48. Remarkably, IFN- (cid:1) production by lymph node NK cells, in contrast to blood NK cells, can be negatively modulated by 2B4/CD48 interactions, indicating a 2B4 inhibitory pathway in lymph node NK cells. Therefore, the CD48 deﬁciency of DCs harbored in inﬂamed lymph nodes that we report in this study might be relevant to successfully activate lymph node NK cells in the early phase of the immune response. Our results show that distinct subsets of human DCs, differently from all other mononuclear hemopoietic cells, speciﬁcally do not express CD48. Moreover, the expression of CD48 depends on the anatomic location of DCs and might be related to the tissue-speciﬁc 2B4 function (activating or inhibitory) of the NK cells
2G Ultra Low Cost Mobile Phone Positioning without GPS

—This paper describes the possible location methods available in Global System for Mobile Communications (GSM) when the Ultra Low Cost (ULC) mobile phone is not equipped with a Global Positioning System (GPS) system. The proposed simplified location procedure is to be used especially in the case of emergency calls, but also in the scope of other applications.
Infrared Surveys for AGN

From the earliest extragalactic infrared studies AGN have shown themselves to be strong infrared sources and IR surveys have revealed new populations of AGN. I briefly review current motivations for AGN surveys in the infrared and results from previous IR surveys. The Luminous Infrared Galaxies, which in some cases house dust-enshrouded AGN, submillimeter surveys, and recent studies of the cosmic x-ray and infrared backgrounds suggest that there is a population of highly-obscured AGN at high redshift. ISO Surveys have begun to resolve the infrared background and may have detected this obscured AGN population. New infrared surveys, particularly the SIRTF Wide-area Infrared Extragalactic Legacy Survey (SWIRE), will detect this population and provide a platform for understanding the evolution of AGN, Starbursts and passively evolving galaxies in the context of large-scale structure and environment.
Highlights of Natural Products in Prostate Cancer Drug Discovery

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Language recovery after epilepsy surgery of the area.

Epilepsy surgery is indicated in select patients with drug-resistant focal epilepsy. Seizure freedom or signi ﬁ cant reduction of seizure burden without risking new neurological de ﬁ cits is the expected goal of epilepsy surgery. Typically, when the seizure onset zone overlaps with eloquent cortex, patients are excluded from surgery. Wepresenta patientwith drug-resistant frontal lobeepilepsy whounderwent successfulsurgerywith resection ofBroca'sarea,primarilyinvolvingtheparstriangularis(BA45). Wereporttransientexpressiveaphasiafollowed by recovery of speech. This case provides new insights into adult neuroplasticity of the language network. (http://creativecommons.org/licenses/by-nc-nd/4.0/).
University of Birmingham Monogenic diabetes syndromes

We developed a variant database for diabetes syndrome genes, using the Leiden Open Variation Database platform, containing observed phenotypes matched to the genetic variations. We pop-ulated it with 628 published disease-associated variants (December 2016) for: WFS1 ( n = 309) , CISD2 ( n = 3) ,ALMS1 ( n = 268),and SLC19A2 ( n = 48)forWolframtype1,Wolframtype2,Alström, and Thiamine-responsive megaloblastic anemia syndromes, respectively; and included 23 previously unpublished novel germline variants in WFS1 and 17 variants in ALMS1. We then investi-gatedgenotype–phenotyperelationsforthe WFS1 gene.Thepresenceofbiallelicloss-of-function variants predicted Wolfram syndrome deﬁned by insulin-dependent diabetes and optic atrophy, with a sensitivity of 79% (95% CI 75%–83%) and speciﬁcity of 92% (83%–97%). The presence of minorloss-of-functionvariantsin WFS1 predictedisolateddiabetes,isolateddeafness,orisolated congenital cataracts without development of the full syndrome (sensitivity 100% [93%–100%]; speciﬁcity78%[73%–82%]). Theabilitytoprovideaprognosticpredictionbasedongenotypewill leadtoimprovementsinpatientcareandcounseling.Thedevelopmentofthedatabaseasarepos-itory for monogenic diabetes gene variants will allow prognostic predictions for other diabetes syndromes as next-generation sequencing expands the repertoire of genotypes and phenotypes. The database is publicly available online at https://lovd.euro-wabb.org.
MINIREVIEW Molecular Detection of the Macrolide Efﬂux Gene: To Discriminate or Not To Discriminate between mef (A) and mef (E)

The presence of a novel macrolide efﬂux system in streptococci was ﬁrst described and ﬁrmly established in 1996 by Sutcliffe et al. (81). This system was phenotypically recognized and characterized to confer low-level resistance (MICs, 1 to 32 (cid:2) g/ml) to 14- and 15-membered macrolides but not to 16-membered macrolides, lincosamides, or streptogramin B (or their analogues). This phenotypic pattern of antibiotic resistance was referred to as M-type resistance and is in contrast to the MLS B phenotype, which confers constitutive high-level resistance (MICs, (cid:1) 256 (cid:2) g/ml) to macrolides, lincosamides, as well as streptogramin B. In the same year Clancy et al. (16) identiﬁed the gene responsible for this novel efﬂux system in Streptococcus pyogenes , and it was designated mef (A). This gene was deposited in the public DNA databases and could be considered the reference sequence for the mef (A) gene (Gen-Bank accession number U70055). Tait-Kamradt et al. (84) later identiﬁed a similar gene in Streptococcus pneumoniae that at the time was
OF ENVIRONMENTAL CROWDEDNESS ON OFFLINE AND ONLINE WORD OF

Consumers engage in WOM in social settings, which includes crowded settings. This research investigates WOM in crowdedness and other possible influential factors such as comfort, people in the crowd and personality traits. I propose that people who are comfortable, accompanied or extraverted will engage in offline WOM. While people who are uncomfortable, alone or introverted will prefer online WOM as it gives them an opportunity to immerse in their mobile phones. A study was conducted in an organic crowd. The results demonstrate relationships between crowdedness and WOM with potential significant results when considering larger samples in future research.
TCRM_A_206066 663..672

*These authors contributed equally to this work Abstract: Hyponatremia, defined as serum sodium concentration <135 mEq/l, is the most common electrolyte balance disorder in clinical practice. Many causes are listed, but syndrome of inappropriate antidiuretic hormone secretion (SIADH) is certainly the most relevant, mainly in oncological and hospitalized patients. In this review, the pathophysiological and clinical aspects are described in detail. Patients’ extensive medical history and structured physical and biochemical tests are considered the milestones marking the way of the SIADHmanagement as to provide early detection and proper correction. We focused our attention on the poor prognostic role and negative effect on patient’s quality of life of SIADH-induced hyponatremia in both malignant and nonmalignant settings, stressing how optimal management of this electrolyte imbalance can result in improved outcomes and lower health costs.
Auditors in Convergence with Corporate Financial Reporting and International Financial Reporting Standard in Nigeria

The study looked at the challenges faced by the Nigerian Auditors in compliance with IFRS. The study uses the survey method to obtain information from sampled audit firms. Data were obtained through questionnaires and were analyzed with the use of chi-square statistical technique. It was discovered that the major challenges befalling auditors is the issue of adequate training and it was therefore recommended that auditors should train themselves through attending workshops, seminars, professional training and by getting materials that would assist in addressing this challenges and also train their clients to this effect.