Miracle-dz/UniFAR-FTUs huggingface dataset:
Peripapillary and macular microvasculature in neovascular age-related macular degeneration in long-term and recently started anti-VEGF therapy versus healthy controls

Aim To investigate the peripapillary and macular microvasculature in neovascular age-related macular degeneration (nAMD) in recently started versus long-term anti-vascular endothelial growth factor (VEGF) therapy and healthy controls. Methods Eyes with nAMD treated in a treat-and-extend regimen were assigned to group 1 (<5 injections) or 2 (≥20 injections) whereas group 3 constituted the healthy age-matched controls. Blood flow signals were acquired using PLEX® Elite 9000 swept-source optical coherence tomography angiography (OCTA) of the macular and peripapillary regions. Mean ganglion cell complex (GCC) thickness values were quantified using spectral-domain optical coherence tomography (SD-OCT). Results Including 80 eyes whereof 40 controls, macular superficial perfusion density was significantly reduced in group 1 and 2 compared to controls (p < 0.001; p = 0.010) without a difference between groups 1 and 2. Peripapillary perfusion parameters did not correlate with post-operative intraocular pressure (IOP) or number of anti-VEGF injections. Mean peripapillary flux index was significantly lower in group 2 than in controls (p = 0.023) and significantly decreased in the nasal quadrants for both AMD groups compared to group 3 (p = 0.013; p < 0.001). Mean peripapillary perfusion density was significantly reduced in both AMD groups compared to controls (0.515 ± 0.02 versus 0.556 ± 0.03, p < 0.0001). Conclusion Frequency of anti-VEGF treatment in nAMD and post-operative IOP showed no correlation with peripapillary perfusion parameters, but anti-VEGF treated nAMD patients exhibited partly altered peripapillary perfusion compared to healthy controls. Reduced macular perfusion density of the inner retina in anti-VEGF treated nAMD compared to healthy controls might be discussed as an anti-VEGF treatment effect or a characteristic of nAMD.
Editorial: Existential narratives: Increasing psychological wellbeing through story

COPYRIGHT © 2023 Das, van Krieken, Kalch and Khoo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Editorial: Existential narratives: Increasing psychological wellbeing through story
Seasonal variation of airborne fungal diversity and community structure in urban outdoor environments in Tianjin, China

Airborne fungi are ubiquitous in human living environments and may be a source of respiratory problems, allergies, and other health issues. A 12 months study was performed to investigate the diversity, concentration and community structure of culturable airborne fungi in different outdoor environments of Tianjin City, using an HAS-100B air sampler. A total of 1,015 fungal strains belonging to 175 species and 82 genera of Ascomycota 92.5%, Basidiomycota 7%, and Mucoromycota 0.3% were isolated and identified using morphological and molecular analysis. The most abundant fungal genera were Alternaria 35%, Cladosporium 18%, Penicillium 5.6%, Talaromyces 3.9%, Didymella 3%, and Aspergillus 2.8%, while the most frequently occurring species were A. alternata (24.7%), C. cladosporioides (11%), A. tenuissima (5.3%), P. oxalicum (4.53%), and T. funiculosus (2.66%). The fungal concentration ranged from 0 to 340 CFU/m3 during the whole study. Environmental factors, including temperature, relative humidity, wind speed, and air pressure exerted a varying effect on the presence and concentration of different fungal taxa. The four analyzed seasons showed significantly different airborne fungal communities, which were more strongly influenced by air temperature and relative humidity in spring and summer, whereas wind speed and air pressure had a stronger effect in autumn and winter. Fungal communities from green and busy sites did not show significant differences over the four analyzed seasons, which may be due to the effect of the surrounding environments characterized by high human activities on the air of the relatively small parks present in Tianjin. The present study provided valuable information on the seasonal dynamics and the environmental factors shaping the diversity and concentration of the analyzed outdoor airborne fungal communities, which can be of help for air quality monitoring, microbial contamination control, and health risk assessment in urban environments.
CircCCDC66: Emerging roles and potential clinical values in malignant tumors

Circular RNAs (circRNAs) are endogenous non-coding RNAs (ncRNAs) with a closed-loop structure. In recent years, circRNAs have become the focus of much research into RNA. CircCCDC66 has been identified as a novel oncogenic circRNA and is up-regulated in a variety of malignant tumors including thyroid cancer, non-small cell carcinoma, gastric cancer, colorectal cancer, renal cancer, cervical cancer, glioma, and osteosarcoma. It mediates cancer progression by regulating epigenetic modifications, variable splicing, transcription, and protein translation. The oncogenicity of circCCDC66 suppresses or promotes the expression of related genes mainly through direct or indirect pathways. This finding suggests that circCCDC66 is a biomarker for cancer diagnosis, prognosis assessment and treatment. However, there is no review on the relationship between circCCDC66 and cancers. Thus, the expression, biological functions, and regulatory mechanisms of circCCDC66 in malignant tumor and non-tumor diseases are summarized. The clinical value and prognostic significance of circCCDC66 are also evaluated, which can provide insights helpful to those exploring new strategies for the early diagnosis and targeted treatment of malignancies.
The performance of index-based policies for bandit problems with stochastic machine availability

We consider generalisations of two classical stochastic scheduling models, namely the discounted branching bandit and the discounted multi-armed bandit, to the case where the collection of machines available for processing is itself a stochastic process. Under rather mild conditions on the machine availability process we obtain performance guarantees for a range of controls based on Gittins indices. Various forms of asymptotic optimality are established for index-based limit policies as the discount rate approaches 0.
Editorial: Insights in health informatics-2021

COPYRIGHT © 2023 He and Musa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Square patterns and secondary instabilities in driven capillary waves

Amplitude equations (including nonlinear damping terms) are derived which describe the evolution of patterns in large-aspect-ratio driven capillary wave experiments. For drive strength just above threshold, a reduction of the number of marginal modes (from travelling capillary waves to standing waves) leads to simpler amplitude equations, which have a Lyapunov functional. This functional determines the wavenumber and symmetry (square) of the most stable uniform state. The original amplitude equations, however, have a secondary instability to transverse amplitude modulation (TAM), which is not present in the standing-wave equations. The TAM instability announces the restoration of the full set of marginal modes.
Flexural waves in a floating ice sheet: Modeling and comparison with data

Ice vibrations caused by a vertical impulse force are calculated in this paper using fluid‐loaded thin elastic plate theory. The plate response is calculated in the frequency domain, multiplied with the source spectrum and inverse Fourier transformed to obtain the time domain solution. The time domain solution is compared with the vertical‐axis geophone array data collected in the Arctic on a smooth ice floe using a vertical hammer strike as the source. The model, assuming a linear frequency dependence in ice attenuation, provides a reasonably good fit to the spectral densities as a function of distance for three bands of frequencies. The modeled waveforms along the array of receivers matches reasonably well with the data. Frequency‐wave number analysis is applied to the modeled time series as was done for the data. Overall good agreement was found between the modeled and measured frequency dispersion curves but the model could not account for the splitting of the frequency dispersion seen in the data. Th.
Rise of the planet of rare anemias: An update on emerging treatment strategies

Therapeutic options for rare congenital (hemoglobinopathies, membrane and enzyme defects, congenital dyserythropoietic anemia) and acquired anemias [warm autoimmune hemolytic anemia (wAIHA), cold agglutinin disease CAD, paroxysmal nocturnal hemoglobinuria (PNH), and aplastic anemia (AA)] are rapidly expanding. The use of luspatercept, mitapivat and etavopivat in beta-thalassemia and pyruvate kinase deficiency (PKD) improves transfusion dependence, alleviating iron overload and long-term complications. Voxelotor, mitapivat, and etavopivat reduce vaso-occlusive crises in sickle cell disease (SCD). Gene therapy represents a fascinating approach, although patient selection, the toxicity of the conditioning regimens, and the possible long-term safety are still open issues. For acquired forms, wAIHA and CAD will soon benefit from targeted therapies beyond rituximab, including B-cell/plasma cell targeting agents (parsaclisib, rilzabrutinib, and isatuximab for wAIHA), complement inhibitors (pegcetacoplan and sutimlimab for CAD, ANX005 for wAIHA with complement activation), and inhibitors of extravascular hemolysis in the reticuloendothelial system (fostamatinib and FcRn inhibitors in wAIHA). PNH treatment is moving from the intravenous anti-C5 eculizumab to its long-term analog ravulizumab, and to subcutaneous and oral proximal inhibitors (anti-C3 pegcetacoplan, factor D and factor B inhibitors danicopan and iptacopan). These drugs have the potential to improve patient convenience and ameliorate residual anemia, although patient compliance becomes pivotal, and long-term safety requires further investigation. Finally, the addition of eltrombopag significantly ameliorated AA outcomes, and data regarding the alternative agent romiplostim are emerging. The accelerated evolution of treatment strategies will need further effort to identify the best candidate for each treatment in the precision medicine era.
Effects of immersion in a simulated natural environment on stress reduction and emotional arousal: A systematic review and meta-analysis

Background Although the mental health benefits of exposure to simulated natural environments are well established by researchers from environmental psychology, landscape architecture, and public health, it is unclear whether and to what extent technological immersion affects these benefits. Methods Systematical literature searches were conducted in May 2022 from six databases. The risk of bias was evaluated using the Cochrane’s Risk of Bias tool 2.0 and the Risk of Bias in Non-randomized Studies of Interventions tool. We performed a random-effects meta-regression to investigate the heterogeneity. The immersion levels of included studies were classified by projection devices and motion capture, and then subgroup analysis was conducted. Results Twenty-six publications were included. Exposure to simulated nature was confirmed to be associated with increased positive affect 0.40 [95% confidence interval (CI): 0.22, 0.58], vigor 0.58 (95% CI: 0.30, 0.86), calmness 0.54 (95% CI: 0.17, 0.92) and decreased perceived stress −0.38 (95% CI: −0.71, −0.06), total mood disturbance −0.87 (95% CI: −1.17, −0.57), tension −0.70 (95% CI: −0.99, −0.41), fatigue −0.60 (95% CI: −0.91, −0.28), anxiety −0.72 (95% CI: −1.43, −0.02), depression −0.33 (95% CI: −0.52, −0.14), confusion −0.79 (95% CI: −1.19, −0.40), and anger −0.54 (95% CI: −0.76, −0.31). Gender, health status, study design, mean age, and single exposure duration were not significant when entered in a meta-regression. For positive affect, medium immersion was observed to produce a larger effect than low and high immersion. All included studies had a moderate to high risk of bias. Conclusion Audio-visual exposure to simulated nature contributes to stress relief and emotional arousal. The immersion level explains the heterogeneity of positive affect triggered by simulated nature. Focusing on the technical features will open up new possibilities for combining actual and simulated nature’s mental health benefits.
Atomic structure of closely stacked InAs submonolayer depositions in GaAs

The atomic structure of multiple buried InAs depositions with a nominal thickness below one monolayer, separated by thin GaAs spacer layers, was investigated using Cs-corrected high-resolution transmission electron microscopy. InAs composition maps were obtained with sub-nanometer resolution by local evaluation of the {200}-Fourier coefficients of the lattice images. A strong segregation behavior of the InAs depositions is found, which leads to significant intermixing with the spacer layers. The segregation coefficient R≈0.7 is found to be independent of the spacer thickness, even for thin spacers with a thickness near the segregation length of about 3 monolayers.
Responses of terrestrial ecosystem productivity and community structure to intra-annual precipitation patterns: A meta-analysis

Introduction The productivity and community structures of terrestrial ecosystems are regulated by total precipitation amount and intra-annual precipitation patterns, which have been altered by climate change. The timing and sizes of precipitation events are the two key factors of intra-annual precipitation patterns and potentially drive ecosystem function by influencing soil moisture. However, the generalizable patterns of how intra-annual precipitation patterns affect the productivity and community structures of ecosystems remain unclear. Methods We synthesized 633 observations from 17 studies and conducted a global meta-analysis to investigate the influences of intra-annual precipitation patterns on the productivity and community structures of terrestrial ecosystems. By classifying intra-annual precipitation patterns, we also assess the importance of the magnitude and timing of precipitation events on plant productivity. Results Our results showed that the intra-annual precipitation patterns decreased diversity by 6.3% but increased belowground net primary productivity, richness, and relative abundance by 16.8%, 10.5%, and 45.0%, respectively. Notably, we found that the timing uniformity of precipitation events was more important for plant productivity, while the plant community structure benefited from the increased precipitation variability. In addition, the relationship between plant productivity and community structure and soil moisture dynamic response was more consistent with the nonlinear model. Comclusions The patterns of the responses of plant productivity and community structure to altered intra-annual precipitation patterns were revealed, and the importance of the timing uniformity of precipitation events to the functioning of production systems was highlighted, which is essential to enhancing understanding of the structures and functions of ecosystems subjected to altered precipitation patterns and predicting their changes.
Bivariate distributions with second kind beta conditionals

In this paper the most general bivariate distributions with second kind beta conditionals is fully characterized. This family is closed under inversions and the conditional moments are shown to be rational functions of the conditioned variable. Two subfamilies of dependent distributions is shown to have second kind beta marginals too. Finally, as a particular case, the most general bivariate distribution with second kind Pareto conditionals is characterized.
Glutamine Supplementation Attenuates Bisphenol A-Induced Testicular Toxicity in Rats

Background: The induction of testicular toxicity by bisphenol A (BPA) may involve oxidative stress. Glutamine (Gln) is a rate limiter for the synthesis of glutathione (GSH), which inhibits oxidative stress. Aim: This study assessed the potential of BPA to preserve testicular structure and function in BPA-treated albino rats. Study Settings and Design: Thirty-two adult male albino rats (210–250 g) were randomly allocated to 4 (A-D) of 8 rats per group with the approval of the Research Ethics Committee. Materials and Methods: Groups B-D were orally treated with Gln (20 mg/kg body weight), BPA (50 mg/kg body weight) and Gln (20 mg/kg body weight) + BPA (50 mg/kg body weight) daily for 65 days, respectively. Group A (control) was orally treated with normal saline (0.2 mL) daily for 65 days. At the termination of treatment, the rats were weighed and anaesthetized blood samples were collected and evaluated for gonadal hormones. The testes were weighed and evaluated for sperm parameters, oxidative stress markers and histology. Statistical Analysis Used: The data were analysed using one-way analysis of variance and Bonferroni post hoc test. Results: BPA caused a significant (P < 0.001) decrease in testis and body weights, sperm count, volume, motility and normal morphology when compared to the control. BPA significantly (P < 0.001) decreased serum testosterone, follicle-stimulating hormone, luteinising hormone, testicular catalase, superoxide dismutase, GSH and GSH peroxidase levels relative to control. Significantly (P < 0.001) increased serum prolactin, estradiol and testicular malondialdehyde levels occurred in BPA-treated rats relative to control. The testes of BPA-treated rats showed sloughing and coalescence of germ cells. However, Gln supplementation prevents BPA-induced testicular toxicity. Gln supplementation restored testis histology. Conclusion: Based on the observation in this study, Gln seems effective against BPA-induced testicular toxicity.
MIXED INTEGER PREDICTIVE CONTROL OF A BUCK BOOST CONVERTER

Abstract This paper presents a new approach to solve the on line optimization problems associated to the solution of mixed integer predictive control (MIPC). The MIPC is obtained using an hybrid Model Predictive Control (MPC) approach and a parametrization of the binary variables. Furthermore, the proposed formulation allows for a systematic controller design which can be also applied to nonlinear hybrid systems. A Buck Boost converter is used as case study to illustrate the difficulties associated to the control problem and the advantages of the proposed controller.
Antimicrobial Properties of Ocimum Species: An In Vitro Study

Objective: This study aimed to determine the antimicrobial activity of ethanol-extracts obtained from Ocimum gratissimum L. (clove or African basil, Lamiaceae) and O. santum L. (holy basil) against some microorganisms present in oral cavity related to either medical or dental disease. Materials and Methods: Antimicrobial properties of both ethanol-extracts of Ocimum species against Streptococcus mutans KPSK2, S. pyogenes ATCC 19615, Staphylococcus aureus ATCC 16794, and Candida albicans ATCC 10231 were primarily determined by agar disk diffusion method. The minimum inhibitory concentration (MIC) and minimum bactericidal or fungicidal concentration (MBC or MFC) of these herbal extracts were further determined by broth micro-dilution method. Results: Ethanol-extracts of O. sanctum L. and O. gratissimum L. inhibited the growth of all tested microorganisms in various degrees ranging from the strongest antimicrobial activity of O. sanctum against S. pyogenes [MIC at 0.19% (w/v); MBC at 0.78% (w/v)] to the least inhibitory activity of O. gratissimum against C. albicans [MIC at 12.5% (w/v); undetectable MFC]. The ethanol-extract of O. sanctum showed stronger antimicrobial property against the tested bacteria and fungus than O. gratissimum. The ethanol-extracts of both Ocimum species showed stronger antibacterial than antifungal activity. However, the ethanol-extract of O. gratissimum even at a high concentration of 50% (w/v) was unable to eliminate the tested fungus. Conclusion: Ethanol-extracts of Ocimum species contain effective antibacterial and antifungal properties that may be beneficial for further development of antimicrobial agents in medical and dental fields.
The homogenized equations of motion for an activated elastic lamination in plane strain

The equations of motion for an elastic laminar spatial‐temporal composite are investigated. It is assumed that the composite is binary, that is, it is assembled of two original constituents capable of changing (in space‐time) their material density, as well as their material stiffness. The condition of plane strain was then imposed on the composite. The paper begins by attempting to evaluate the materials' average Lagrangian (action density). In doing so, it immediately becomes apparent that expressions are needed for average momentum and stress. Both quantities are found to depend linearly on average strain and average velocity. After calculating the general Euler equations of motion, isotropy was assumed, and two additional forces (one being of a Coriolis nature) were found in the averaged equations of elastodynamics due to the presence of simultaneous change in both inertial and elastic properties of the original material constituents. The appearance of these two forces is a consequence of both dynamics and plane strain; the Coriolis type force disappears in the case of one dimensional strain that arises when longitudinal dynamic disturbances propagate along an elastic bar.
Dynamical protection of quantum computation from decoherence in laser-driven cold-ion and cold-atom systems

We show that by dynamically modulating the gate fields so as to minimize the spectral overlap of the decoherence and modulation spectra specifically for each qubit, and concurrently controlling all qubits, one can significantly increase the fidelity of quantum computation. Notably, cross-decoherence, introduced by two-qubit entanglement, can be eliminated by appropriate dynamical control. In this scheme, contrary to traditional schemes, one can increase the gate duration, while, simultaneously, increasing the total gate fidelity. Experimental scenarios involving laser-driven cold-ions and cold-atoms are shown to benefit from this counterintuitive scheme.