Miracle-dz/UniFAR-FTUs huggingface dataset:
Susceptibility to Imipenem/Relebactam of Pseudomonas aeruginosa and Acinetobacter baumannii Isolates from Chinese Intra-Abdominal, Respiratory and Urinary Tract Infections: SMART 2015 to 2018

Purpose In recent years, less options are available for treating carbapenem-resistant Acinetobacter baumannii and carbapenem-resistant Pseudomonas aeruginosa. The present study investigates the susceptibility rates to imipenem/relebactam for the treatment of intra-abdominal infections (IAIs), respiratory tract infections (RTIs) and urinary tract infections (UTIs) caused by A. baumannii and P. aeruginosa in China. Patients and Methods A total of 1886 P. aeruginosa and 1889 A. baumannii isolates were collected in 21 centers (7 regions) as a part of the global SMART surveillance program between 2015 and 2018. Antimicrobial susceptibility testing was performed according to the Clinical and Laboratory Standards Institute (CLSI) recommendations using the broth microdilution methodology at Peking Union Medical College Hospital. Results For P. aeruginosa, overall susceptibility rates to imipenem/relebactam were 84.2% at a CLSI breakpoint of ≤2 mg/L compared to 55.7% for imipenem. Susceptibility rates of imipenem-non-susceptible P. aeruginosa to imipenem/relebactam were 64.4% and for multidrug-resistance (MDR) P. aeruginosa susceptibility rates were increased from 25.2% for imipenem to 65.8% for imipenem/relebactam. The susceptibilities of imipenem-non-susceptible and MDR P. aeruginosa strains were similarly restored by imipenem/relebactam in non-ICU and ICU wards. The rate of imipenem-non-susceptibilities A. baumannii isolates was 79.0%, whereas the MDR rate was 81.9%. Relebactam did not change the susceptibilities of imipenem-non susceptible or MDR A. baumannii isolates. Conclusion Imipenem/relebactam provides a therapy option to treat infections caused by MDR or imipenem-non-susceptible P. aeruginosa but not A. baumannii infections in China.
Warmth, competence, and wellbeing: The relationship between parental support, needs satisfaction, and interpersonal sensitivity in Italian emerging adults

ABSTRACT In the Italian context, parental bonding has great relevance in promoting satisfaction of emerging adults’ psychological needs, impacting their wellbeing, also in terms of interpersonal sensitivity. Aims: to analyse, in 497 emerging adults: the direct influence of maternal and paternal bonding on young interpersonal sensitivity and life satisfaction; indirect influence, mediated by the influence of the parents–offspring relationship on the need for relatedness, autonomy, and competence. SEM analysis showed that parental bonding characterized by high warmth and low over-protection could help satisfaction of all three needs; only paternal bonding is directly and positively related with life satisfaction and negatively with interpersonal sensitivity; satisfaction of needs could significantly improve life satisfaction. Implications are discussed in the article.
A Blockchain based Fund Management Scheme for Financial Transactions in NGOs

In the world of the latest technologies, the blockchain is one of the popular techniques for stopping fraudulent activities. Non-Government Organization (NGO) is increasingly being used to support all the needy people across the globe to shape the world’s responsibility towards society for sustainable development. The existing method of donating money and its monitoring is faced with a major corruption problem in several world-renowned NGOs. A blockchain can transform the way the current business of money transaction is being done in NGOs. The blockchain-based application works on the concept of a decentralized system. This article presents a blockchain-based transaction system to prevent corruption and money laundering in NGOs and government fundraising organizations. A Smart contract has been designed to stop any illegitimate block changes during a financial transaction. Since every node has a copy of the ledger, so it is very difficult to perform malicious activity. Furthermore, the donator can watch how the money flows in the different transactions, and everyone can browse the account history. An evaluative judgment, compared with various consensus algorithms, has also been presented along with their complex nature. The decentralized approach has eliminated the chance of a single point of failure, which in turn makes the system robust. The developed framework for the financial transaction using blockchain has been tested using the Rinkeby Test Network. The generators and campaign contracts have been developed and deployed in the Rinkeby testing network. The results indicate the computing to be much more secure and free from the scam in comparison to the traditional client-server financial transaction system. Finally, the proposed approach suggests scenarios such as in NGOs where the introduced security approach should prove to be adequate.
Tourism in a Post-COVID-19 Era: Sustainable Strategies for Industry’s Recovery

In the COVID-19 outbreak context, some industries were seriously affected, and the T&T (travel and tourism) industry is unarguably one of those industries. As the world is slowly moving towards a recovery stage, T&T is lagging in the recovery process, mainly because of people’s perception of safety and a new, more cautious behavior when buying products that are not essential for survival, such as T&T products. In order to discover sustainable recovery paths for the industry and the real impact of the COVID-19 outbreak on consumer perceptions and purchasing behavior, the current quantitative research was developed on the basis of two different representative samples in two different moments: May 2020 and December 2020, with a focus on Romania’s population. The main results indicate that the COVID-19 pandemic has influenced travel patterns and habits regarding philological and economic factors. Psychological factors, primarily the fear of contamination, impact travelers’ willingness to travel and the conditions and preferences for vacation destinations. At least in the medium term, people will avoid traveling in large groups and being in crowded places. Hygiene and health conditions in the host destination can represent essential factors in travel decisions. Confronted with a cautious clientele, tourism businesses (such as transport, accommodation, and catering) should further enhance their hygiene conditions to restore confidence. Moreover, communication is essential in these challenging times to tackle travelers’ fear and concerns.
Spatial and Temporal Evolution of a Pulsed Corona Discharge Plasma

model is used to analyze the spatial and the temporal evolutions of the ion and the electron densities, the potential proles in the discharge region, and the propagation of the ionization front in the reactor. It is shown that the non-neutral space charges produced by the opposite movements of ions and electrons induce a sucient electric eld to cancel the applied eld inside the bulk discharge region. The motion of the electrons near the ionization front is shown to be responsible for the propagation of the ionization front. The numerical study indicates that the properties of the discharge plasma depend strongly on the characteristics of the input voltage pulses, i.e., voltage strength, pulse width and rise time. It is also shown that the stationary corona discharge without accompanying arc breakdown can be created by appropriately selecting the voltage pulse parameters for a given reactor geometry.
Dynamic Lane-Changing Trajectory Planning for Autonomous Vehicles Based on Discrete Global Trajectory

Automatic lane-changing is a complex and critical task for autonomous vehicle control. Existing researches on autonomous vehicle technology mainly focus on avoiding obstacles; however, few studies have accounted for dynamic lane changing based on some certain assumptions, such as the lane-changing speed is constant or the terminal state is known in advance. In this study, a typical lane-changing scenario is developed with the consideration of preceding and lagging vehicles on the road. Based on the local trajectory generated by the global positioning system, a path planning model and a speed planning model are respectively established through the cubic polynomial interpolation. To guarantee the driving safety, passenger comfort and vehicle efficiency, a comprehensive trajectory optimization function is proposed according to the path planning model and speed planning model. In addition, a dynamic decoupling model is established to solve the problems of real-time application to provide viable solutions. The simulations and real vehicle validations are conducted, and the results highlight that the proposed method can generate a satisfactory lane-changing trajectory for automatic lane-changing actions.
The strong clique index of a graph with forbidden cycles

Given a graph G , the strong clique index of G , denoted ω S ( G ) , is the maximum size of a set S of edges such that every pair of edges in S has distance at most 2 in the line graph of G . As a relaxation of the renowned Erdős–Nešetřil conjecture regarding the strong chromatic index, Faudree et al. suggested investigating the strong clique index, and conjectured a quadratic upper bound in terms of the maximum degree. Recently, Cames van Batenburg, Kang, and Pirot conjectured a linear upper bound in terms of the maximum degree for graphs without even cycles. Namely, if G is a C 2 k ‐free graph with Δ ( G ) ≥ max { 4 , 2 k − 2 } , then ω S ( G ) ≤ ( 2 k − 1 ) Δ ( G ) − 2 k − 1 2 , and if G is a C 2 k ‐free bipartite graph, then ω S ( G ) ≤ k Δ ( G ) − ( k − 1 ) . We prove the second conjecture in a stronger form, by showing that forbidding all odd cycles is not necessary. To be precise, we show that a { C 5 , C 2 k } ‐free graph G with Δ ( G ) ≥ 1 satisfies ω S ( G ) ≤ k Δ ( G ) − ( k − 1 ) , when either k ≥ 4 or k ∈ { 2 , 3 } and G is also C 3 ‐free. Regarding the first conjecture, we prove an upper bound that is off by the constant term. Namely, for k ≥ 3 , we prove that a C 2 k ‐free graph G with Δ ( G ) ≥ 1 satisfies ω S ( G ) ≤ ( 2 k − 1 ) Δ ( G ) + ( 2 k − 1 ) 2 . This improves some results of Cames van Batenburg, Kang, and Pirot.
Investigation of breakdown characteristics of N2, SF6 and SF6-N2 mixtures under pressure

Breakdown behaviour of a rod-plane gap and a plane-plane gap is investigated for N 2 and N 2 -SF 6 mixtures for pressure up to 8 bar. In N 2 , results show the role of the nonuniformity of the applied electrical field on U 50 breakdown voltage values in both polarities. Average values of reduced breakdown field associated to the guiding fields of negative streamer are measured versus the pressure in N 2 . 'The effects of surface roughness on U 50 are pointed out. The critical reduced field versus pressure for N 2 , SF 6 and different mixtures is measured .
Study of Separately and in Combination Impacts of Zinc-Oxide and Multiwall-Carbon-Nanotube on the Freshwater Prawn (Macrobrachium Nipponense De Haan, 1849), in Laboratory Condition

Nanomaterials (NMs) have settling behavior and accumulate in the benthic area of the aquatic ecosystems. Because of deposit-omnivorous feeding behavior of decapod crustaceans, these order species are appropriate biological models to assay NMs eco-toxicological effects. The present study evaluated the toxicity effects of ZnO and MWCNTs nanomaterials as separately and in combination on antioxidant enzymes activities, CHH hormone, hematology, reproductive performance, and hepatopancreas lesions of the Macrobrachium nipponense. The study was carried out in two stages. At the first experiment, concentrations of ZnO (0, 1, 10, 30, 50 mg/L) and MWCNTs (0, 5, 10, 15, 20 mg/L) were assayed then at the second experiment, two higher concentrations of the NMs in the first stage were compared in combined treatments. The experimental tanks (500 l RAS system) were stocked 12 females and four males during 60 days. Both NMs showed dose-dependent toxicity effects on M. nipponense reproductive parameters and especially eggs fertilization rate. Also, the results depicted that by increasing the NMs concentrations, inter-molt and inter-spawn periods were postponed so that in 50 ppm ZnO and 15 and 50 ppm MWCNTs treatments reproduction activities were stopped. The findings showed that CHH hormone release and superoxide dismutase (SOD) enzyme activity have direct relations to the NMs levels independently and in combination. Also, the results demonstrated that large granular hemocyte (LGH) deal with NMs detoxification in decapod crustacean’s hemolymph mainly. The NMs did not show any effect on ALT and AST enzymes activities in muscle tissue independently, but the NMs combined effects on these enzymes activities were significant. Also, the NMs caused hepatocyte enlargement, melanization, apoptosis, and necrosis damages in the hepatopancreas. The findings showed that ZnO and MWCNTs NMs have strongly adverse effects on M. nipponense, and this species is an appropriate bio-indicator and bio-monitor organism for NMs contaminations in the freshwater aquatic environments.
The Factors’ Affecting Innovative Competency Development of Vietnamese Universities’ Lecturers

The world’s in the process of globalization with the Fourth Industrial Revolution that connects people, influential nations, interactions, interdependence in every way. To survive and develop all of us must constantly innovate, create new products excel. Optimal solutions and breakthrough decisions’re entirely dependent on the creativity of each member of the organization. In this context, higher education, the role of universities’ teachers’re seen as the vanguard of innovation with mission to train human resources of high quality to meet the needs’ economic development - social. The articles’ give three groups of factors that influence the development of innovative competency’s university teachers; in which influential group’s within themselves, motives, the individual characteristics, the energy of the behavior. Self-motivation’s the key to formation and creation. And the way to develop the creative ability of university lecturers’re awaken the potential in each person so that they know how to self-control, master, orient themselves to develop their career.
Real earnings manipulation surrounding mergers and acquisitions: the targets’ perspective

Purpose This paper aims to investigate whether UK public targets manage their earnings using real activities manipulation in the period prior to the announcement of a mergers and acquisition (M&A). It also examines whether the payment method in M&As affects the degree to which takeover targets manipulate earnings. Design/methodology/approach Using a sample of 131 UK listed targets acquired over the period 1995–2013, this paper examines real earnings management (REM) by employing OLS regression models. The data related to deals have been mainly collected from Thomson One Banker and Thomson Reuters Eikon databases. REM is examined by investigating abnormal cash flow from operations, abnormal discretionary expenses and abnormal production costs. This analysis was supplemented by conducting additional robustness checks. Findings The results show that UK takeover targets manage earnings upwards through cutting discretionary expenses in the year prior to the acquisition, while they do not do so by manipulating sales or production costs. Moreover, targets of cash-only or mixed-payment deals do not have the same strong motivation to manage their earnings as stock-financed deal target counterparts do. Our results continue to hold after using alternative accrual earnings management (EM) measures, controlling for unobservable firm heterogeneity using the fixed-effect model and controlling for endogeneity using the two-stage Heckman (1979) model. Practical implications The main findings of this study could be beneficial for various parties involved M&As, such as standard setters and regulators. A need arises to improve disclosure rules and enhance overall financial reporting quality in the capital markets with the aim of reducing information asymmetry and agency conflicts. Originality/value As far as the literature on EM around M&As is concerned, only EM by acquirers has been examined, and not much attention has been paid to targets’ EM.
Accelerated Hypofractionated Radiotherapy With Simultaneous Integrated Boost With Volumetric Modulated Arc Technique in Patients With Breast Cancer: a Phase 2 Study.

PurposeTo assess feasibility of accelerated hypofractionated radiotherapy with simultaneous integrated boost (SIB) with volumetric modulated arc technique (VMAT) in patients with breast cancer.Methods Total 27 patients after breast conserving surgery (BCS) were included in this study. Patients were planned on 4-dimensional computerized tomogram (4D-CT) and contouring was done using RTOG guidelines. Dose delivered was 34 Gy/10#/2wk to the breast and 40 Gy/10#/2wk to the tumor bed as SIB with VMAT technique. The primary endpoint was grade 2 acute skin toxicity. Doses to the organs at risk were calculated. Toxicities and cosmesis were assessed using RTOG LENT-SOMA and HARVARD/NSABP/RTOG grading scales, respectively. Disease-free survival (DFS) and overall survival (OS) was calculated with Kaplan Meier curves.ResultsMean age of the patients was 42 years. Left and right breast cancer was seen in 17 (63%) and 10 (37%) patients, respectively. Ipsilateral lung mean V16 and contralateral lung V5 was 16.01% and 3.73%, respectively. Mean heart dose from the left and right breast was 7.25Gy and 4.37Gy, respectively. Mean dose to the contralateral breast, oesophagus and spinal cord was 2.64Gy, 3.69Gy and 3.15Gy, respectively. Thyroid V25 mean was 19.69%. Grade 1 and 2 acute skin toxicity was observed in 9 (33%) and 5 (18.5%) patients, respectively. Grade 2 hyperpigmentation, edema and induration were observed in 1 (3.7%), 2 (7.4%) and 4(14.8%) patients, respectively. Mild breast pain and arm/shoulder discomfort were reported by 1 (3.4%) patient each. Median follow-up was 48 months (range 12-58 months). At 4 years breast induration, edema and fibrosis each were observed in 1(3.7%) patient. Cosmesis was excellent and good in 21 (78%) and 6 (22%) patients, respectively. Local recurrence and distant metastases occurred 1(3.7%) and 2(7.4%) patients, respectively. DFS and OS at 3-years was 88% and 92%, respectively.ConclusionWith this RT schedule acute and late toxicity rates were acceptable with no adverse cosmesis. Local control, DFS and OS were good.
Separation and concentration of butanol from acetone-butanol-ethanol mixed solution by pervaporation

Butanol was produced with a very low mass concentration of fermentation product by microbial fermentation.In order to separate and concentrate butanol efficiently,the concentration of butanol from a model solution containing acetone,butanol and ethanol(ABE) was studied by pervaporation.The results show that the butanol flux increases with the rise of temperature,permeate pressure,cross flow rate and butanol mass concentration;the selectivity of pervaporation for butanol is the highest at 50 ℃,and the decrease of permeate pressure and the increase of butanol mass concentration result in the reduction of selectivity.These experiments prove that the pervaporation technology can be used as an efficient method for separation and concentration of butanol from ABE solution,and the mass transfer and separation of different components in ABE system can be well described and predicted by using resistance-in-series model of solution-diffusion-desorption.
Manufacture of Hard Gelatin Capsules From a Lyophilisate of the Morus Nigra Fruit

Morus nigra L. (M. nigra L.) belongs to the Moraceae family. Traditional medicine for its physicochemical properties. To evaluate the physicochemical composition and pharmaceutical stability of hard gelatin capsules of the freeze-dried fruit of M. nigra L. The content of total phenols (CFT) and antioxidant capacity (CA) were evaluated by spectrophotometry, the content of ash, moisture, protein, fat and fiber were determined according to their own standard. The CFT and CA were 25.4 mg gallic acid equivalents/g of sample, and 74.1% inhibition, respectively. On the other hand, the values of ash, moisture, protein, fat and fiber were 4.2%, 7.9%, 3.9%, 0.5% and 3.6%, respectively. Lyophilized M. nigra fruit may be a novel candidate for the development of gelatin hard capsules and other new pharmaceutical products.
Switching-Cell Buck–Boost AC–AC Converter With Common-Ground and Noninverting/Inverting Operations

This article proposes a switching-cell-based bipolar buck–boost ac–ac converter that can provide multiple modes of operation, including noninverting buck operation, noninverting boost operation, inverting buck–boost operation, and adjustable noninverting buck–boost operation with two control duty ratios. Each fundamental switching-cell in the proposed converter is composed of a unidirectional buck circuit with no short-circuit or open-circuit problems, increasing its robustness. Hence, safe commutation is naturally realized without the use of RC snubbers or soft-commutation strategies, removing the need for pulsewidth modulation deadtimes. External fast recovery diodes are utilized, avoiding the high-frequency conduction of MOSFET's body diodes and eliminating their slow reverse recovery problem and corresponding power loss. The proposed converter shares a common ground between input and output ports, offers support for reactive loads, draws continuous sinusoidal current from ac mains, and delivers a continuous output current. The converter is suitable for ac voltage regulation applications, notably as a dynamic voltage restorer, compensating extensive magnitudes of both grid voltage sags and swells. Circuit operation and analysis are provided for all the proposed modes of operation. Experimental results obtained using a 400-W laboratory-scale hardware verify the theoretical analysis.
Label propagation community detection algorithm based on density peak optimization

Community structure detection in complex network structure and function to understand network relations, found its evolution rule, monitoring and forecasting its evolution behavior has important theoretical significance, in the epidemic monitoring, network public opinion analysis, recommendation, advertising push and combat terrorism and safeguard national security has wide application prospect. Label propagation algorithm is one of the popular algorithms for community detection in recent years, the community detection algorithm based on tags spread the biggest advantage is the simple algorithm logic, relative to the module of optimization algorithm convergence speed is very fast, the clustering process without any optimization function, and the initialization before do not need to specify the number of complex network community. However, the algorithm has some problems such as unstable partitioning results and strong randomness. To solve this problem, this paper proposes an unsupervised label propagation community detection algorithm based on density peak. The proposed algorithm first introduces the density peak to find the clustering center, first determines the prototype of the community, and then fixes the number of communities and the clustering center of the complex network, and then uses the label propagation algorithm to detect the community, which improves the accuracy and robustness of community discovery, reduces the number of iterations, and accelerates the formation of the community. Finally, experiments on synthetic network and real network data sets are carried out with the proposed algorithm, and the results show that the proposed method has better performance.