Miracle-dz/UniFAR-FTUs huggingface dataset:
The Karyopherin Kap142p/Msn5p Mediates Nuclear Import and Nuclear Export of Different Cargo Proteins

We have identified a novel pathway for protein import into the nucleus. Although the product of Saccharomyces cerevisiae gene MSN5 was previously shown to function as a karyopherin (Kap) for nuclear export of various proteins, we discovered a nuclear import pathway mediated by Msn5p (also referred to as Kap142p) . We have purified from yeast cytosol a complex containing Kap142p and the trimeric replication protein A (RPA), which is required for multiple aspects of DNA metabolism, including DNA replication, DNA repair, and recombination. In wild-type cells, RPA was localized primarily to the nucleus but, in a KAP142 deletion strain, RPA was mislocalized to the cytoplasm and the strain was highly sensitive to bleomycin (BLM). BLM causes DNA doublestrand breaks and, in S. cerevisiae , the DNA damage is repaired predominantly by RPA-dependent homologous recombination. Therefore, our results indicate that in wild-type cells a critical portion of RPA was imported into the nucleus by Kap142p. Like several other importrelated Kap–substrate complexes, the endogenous RPA– Kap142p complex was dissociated by RanGTP, but not by RanGDP. All three RPA genes are essential for viability, whereas KAP142 is not. Perhaps explaining this disparity, we observed an interaction between RPA and Kap95p in a strain lacking Kap142p. This interaction could provide a mechanism for import of RPA into the nucleus and cell viability in the absence of Kap142p. Together with published results (Kaffman, A., N.M. Rank, E.M. O’Neill, L.S. Huang, and E.K. O’Shea. 1998. Nature . 396:482–486; Blondel, M., P.M. Alepuz, L.S. Huang, S. Shaham, G. Ammerer, and M. Peter. 1999. Genes Dev . 13:2284–2300; DeVit, M.J., and M. Johnston. 1999. Curr. Biol . 9:1231–1241; Mahanty, S.K., Y. Wang, F.W. Farley, and E.A. Elion. 1999. Cell . 98:501–512) our data indicate that the karyopherin Kap142p is able to mediate nuclear import of one set of proteins and nuclear export of a different set of proteins.
KIF5B - EGFR Fusion: A Novel EGFR Mutation in Lung Adenocarcinoma

: With the rapid development of detection methods, next-generation sequencing (NGS) technology as a new technology, some novel epidermal growth factor receptor (EGFR) gene fusions comprising the EGFR linked to various fusion partners, most commonly RAD51 , are detected in the non-small cell lung cancer (NSCLC). We described a case of an unreported kinesin family member 5B ( KIF5B )- EGFR in NSCLC and the efficacy of EGFR tyrosine kinase inhibitors (TKIs) to this specific fusion. Considering this rare EGFR fusion and remarkable response to EGFR-TKI, we should realize the importance of these rare EGFR fusions, the advances in diagnostic techniques and personalized care for lung cancer patients.
A Study on the Influence of Socioeconomic Status on Residents’ Subjective Well-being Based on an Empirical Analysis of CGSS2015 Data

Residents’ happiness is an important indicator of a country’s development and a key issue of social concern. In this paper, we found that residents’ socioeconomic status has a significant positive effect on subjective well-being based on the 2015 China General Social Survey data, regression using ordinary least squares (OLS) model and ordered probit model. In addition, marital status, social equity, and other aspects also have an impact on subjective well-being. Based on this, measures such as increasing residents’ income, increasing investment in education, and increasing social services to improve residents’ subjective socioeconomic status are proposed to improve people’s livelihood and play the role of economic and social status in improving residents’ subjective well-being.
The Impact of Decision-Making and Problem-Solving Skills on Mental Health Status among Industrial Workers through Life- Skills Education

Background: Essential Skills such as Decision-making and Problem-solving skills training through inculcating Life-skills education have shown a decrease in negative effectively on mental health status in workers. Objective: The study was aimed to examine “the impact of decision-making and problem-solving skills on mental health status among industrial workers through Life-skills education. ” Methodology: The research was an experiment with pretestposttest control group design. A sample of 100 workers was randomly selected from HMT Watches Ltd, Bangalore, India. The sample included an equal number of male (N=50) and female (N=50) workers. The samples were allocated to experimental and control group. Both groups were pre-tested by using research tools, such as mental health scale, decision making, and problem-solving skills self-assessment questionnaires for data collection. Research objectives through hypothesis guided the study. The experimental group received training in decision-making and problem-solving skills through life-skills education for 5 sessions, 2 hours per session per week. Both groups were post-tested, collected data was processed at inferential and descriptive levels using SPSS and for analytic analysis “T” test was used for variables. Findings: Findings of the study indicated that training in decision-making and problem-solving skills significantly found a positive effect on mental health, i.e., increased mental health status relatively reduced mental health problems. Conclusion: Decisionmaking and Problem-solving skills training through Life-skills education were proved effective in reducing mental health problems by enhancing mental health status.
Mixed-effects LS-SVR for longitudinal dat

In this paper we propose a mixed-effects least squares support vector regression (LS-SVR) for longitudinal data. We add a random-effect term in the optimization function of LS-SVR to take random effects into LS-SVR for analyzing longitudinal data. We also present the model selection method that employs generalized cross validation function for choosing the hyper-parameters which affect the performance of the mixed-effects LS-SVR. A simulated example is provided to indicate the usefulness of mixed-effect method for analyzing longitudinal data.
Endovascular Recanalisation of Chronic Iliofemoral Obstructions with Dedicated Venous Stents

Approximately 60% of patients with acute iliofemoral deep vein thrombosis recover without further symptoms. However, 40% will have some degree of Post-Thrombotic Syndrome (PTS), and 4% will develop severe PTS. PTS is the most common complication; it reduces quality of life and increases DVT-related costs. The clinical symptoms and severity of PTS may vary; the most common symptoms include oedema, pain, hyperpigmentation, lipodermatosclerosis, and ulceration. PTS is based on the principle of outflow obstruction. It may be caused by venous hypertension, and may lead to valve damage and venous reflux or insufficiency. A significant lumen reduction within the iliac vein system is defined as an aspect ratio of ≥ 2. Recent technical developments and new dedicated venous stent techniques have permitted recanalization of complex venous outflow obstructions. First-in-man safety and efficacy data concerning the new dedicated venous stents are very promising, but long-term data are still awaited. Special Article Venous Thrombosis Endovascular Recanalisation of Chronic Iliofemoral Obstructions with Dedicated Venous Stents Lichtenberg M* Department of Angiology, Klinikum Arnsberg, Germany *Corresponding author: Michael Lichtenberg, Klinikum Hochsauerland, Karolinenhospital, Klinik für Angiologie, Stolte Ley 5, D-59759 Arnsberg, Germany Received: July 09, 2019; Accepted: August 07, 2019; Published: August 14, 2019
Composite Event-Driven

—Implementing multi-touch and multi-modal systems requires splitting the code across several event handlers, which complicates programmers work. The present paper ﬁnds the root of this problem in the event-driven paradigm; more concretely, in the fact that event-driven languages lack abstractions for representing event sequences. It then suggests to augment event-driven languages so that programmers can have the possibility to deﬁne event sequences –herein called composite events– that can then be bound to event handlers. The main features of the composite event-driven language developed by the authors are outlined, as well as its beneﬁts and problems. The paper suggests that, since its design, the event-driven paradigm was tailored for mouse-based interactions, and it may be important to question its suitability for implementing multi-touch and multi-modal interactions.
of in domain for by

25 An Escherichia coli ATP-dependent two-component protease, ClpYQ(HslUV), 26 targets the SulA molecule, an SOS induced protein. ClpY recognizes, unfolds and 27 translocates the substrates into the proteolytic site of ClpQ for degradation. ClpY is 28 divided into three domains N, I and C. The N domain is an ATPase; the C domain 29 allows for oligomerization, while the I domain coordinates substrate binding. In the 30 ClpYQ complex, two layer pore sites, pore I and II, are in the center of its hexameric 31 rings. However, the actual roles of two outer-loop (130~159 aa, L1 and 175~209 aa, 32 L2) of the ClpY-I for of SulA are this
DMSO_A_348870 269..280

1Department of Endocrinology, Hebei General Hospital, Shijiazhuang, 050017, People’s Republic of China; 2Graduate School of Hebei Medical University, Shijiazhuang, 050017, People’s Republic of China; 3Department of Internal Medicine, School of Clinical Medicine, North China University of Science and Technology, Tangshan, 063210, Hebei, People’s Republic of China; 4Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital Shijiazhuang, Hebei, 050051, People’s Republic of China; 5Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, 050017, People’s Republic of China
Report of a Double-Blind Clinical Trial With Ambulatory Blood Pressure Monitoring

Methods: In a double-blind randomized clinical trial, 71 patients with uncontrolled BP were enrolled in a pharmaceutical care program or in a control group and underwent a series of cognitive tests. The primary outcome was change in ambulatory BP (ABP) between the baseline evaluation and the final visit 6 months later. The secondary outcomes were the frequency of drug-related problems and adherence as determined by plasma levels of hydrochlorothiazide.
An Analysis of Tourist Satisfaction in Cultural and Environmental Aspects of the Buon Ma Thuot Coffee Festival

Received: April 01, 2021 This paper aimed at analyzing tourist satisfaction of cultural values and environmental aspects of the Buon Ma Thuot Coffee Festival (BCF). We found that tourists were highly satisfied with most of the cultural attributes but were disappointed with most environmental attributes at the BCF. Therefore, we suggested the BCF strategy should be revised by taking into account the tourists’ benefits and achievability and measures should be taken to maintain or enhance the cultural attributes and eliminate weaknesses regarding the environment of the BCF. Accepted: September 01 , 2021
Two Reference Time Scales for Studying the Dynamic of Liquid Films Cavitation

Two formulas, one for the characteristic time of filling a void with the vapor of the surrounding liquid, and one of filling the void by diffusion of the dissolved gas in the liquid, are derived. Based on this analysis, it is seen that in an oil film bearing operating under dynamic loads, the content of the cavitation region should be oil vapor rather than the air liberated from solution, if the oil is free of entrained air. NOMENCLATURE mass concentration of gas Cs saturation value of C coefficient of binary diffusion H Henry's constant thickness of liquid film Jcond number of molecules condensing on unit surface area in unit time Jdiff mass of gas diffused into the void from unit surface area of liquid in unit time Jevap number of molecules evaporating from unit surface area in unit time k Boltzmann constant, 1.380622x10 -23 J/K thickness of diffusion layer M molecular weight m mass of a molecule n number of molecules in unit volume neq P Ps R
INCIDENCE OF POSTERIOR DISLOCATION OF HIP IN POSTEROLATERAL (MOORE) APPROACH VS ANTEROLATERAL (HARDINGE) APPROACH IN HIP ARTHROPLASTY AFTER FRACTURE NECK OF FEMUR

Objective: To compare the incidence of posterior dislocation of hip joint in Moore and Hardinge approach in hip arthoplasty for the treatment of fracture neck of femur during 12 weeks follow-up after surgery Materials & Methods: This multicenter randomized controlled was conducted at Department of Orthopedic Surgery, Bahawal Victoria Hospital, Bahawalpur, Civil Hospital Bahawalpur and Shahid Surgical Hospital Bahawalpur from July 2016 To July 2019. A total of 300 patients, 65 to 85 years of age with Garden type IV fracture of neck of femur were included in the study. Patients were divided into two age groups A (Moore approach) & B (Hardinge approach) randomly. Posterior Dislocation of hip joint was compared between the both groups. Results: In present study, mean age of patients was 78.59 ± 4.48 years. The mean age of patients in group A was 79.92 ± 4.38 years and in group B was 78.58 ± 5.27 years. In study group A, posterior dislocation was found in 15 (10%) patients while in study group B posterior dislocation was found in 4 (2.67%) patients. Significantly (P = 0.013) higher posterior dislocation was found in study group A as compared to study group B. Conclusion: This study concluded that incidence of posterior dislocation of hip joint was less after Hardinge approach compared to Moore approach in hip arthoplasty for the treatment of fracture neck of femur.
Routes to global glaciation: Supplementary Text

Here, αc is the limit of the albedo in a cold state, and αw the limit of the albedo in a warm state. Ti denotes the transitional temperature at which the albedo is halfway between αc and αw, and γ sets the temperature scale over which this transition occurs. The sensitivity of our results to our assumptions about albedo is also further explored below. The arctan function captures the qualitative behavior of the transition, and is mathematically convenient (it is continuously differentiable). Our emphasis is on understanding the qualitative dynamics of the system; we expect that the results presented in the paper are independent of the detailed nature of the parametrization. Assuming that weathering must go to zero with decreasing T similar to the way in which α(T ) goes towards its maximum value αc with decreasing T , we parametrize W (T ) in a similar way:
Adaptive density estimation under dependence

Assume that (Xt)t∈Z is a real valued time series admitting a common marginal density f with respect to Lebesgue’s measure. Donoho et al. (1996) propose near-minimax estimators f̂n based on thresholding wavelets to estimate f on a compact set in an independent and identically distributed setting. The aim of the present work is to extend these results to general weak dependent contexts. Weak dependence assumptions are expressed as decreasing bounds of covariance terms and are detailed for different examples. The threshold levels in estimators f̂n depend on weak dependence properties of the sequence (Xt)t∈Z through the constant. If these properties are unknown, we propose cross-validation procedures to get new estimators. These procedures are illustrated via simulations of dynamical systems and non causal infinite moving averages. We also discuss the efficiency of our estimators with respect to the decrease of covariances bounds.
Ellipsoidal set based tracking with nonlinear measurements

There are many target tracking applications where measurements are nonlinearly related to target state. Typical examples of this include active sonar tracking with range-bearing measurements and passive sonar tracking with bearings-only measurements, where target state is position and velocity in Cartesian coordinates. In this paper, ellipsoidal set based estimators are derived for both of these nonlinear measurement scenarios. The premise of an estimate that provides a guaranteed bound on target state is maintained throughout the paper. Monte Carlo simulation results are presented for each type of nonlinear measurement, including a comparison with the extended Kalman filter in the case of bearings-only measurements.
Operations Research a Profit Making Tool

Operations Research a Profit Making Tool: Impacts on Bottom Line Yahia Zare Mehrjerdi This book is designed to address the needs of those who wish to understand and appreciate the benefits that operations research as a tool would bring to the organization. The book specially emphasizes the roles operations research's tools/approaches as ssuch as linear programming, goal programming, nonlinear programming and so on can have on profit making in small and large organizations.
Effect of Media on Human Behaviour

In this era of technological advancement, media as technologies have dramatically affected the human behaviour and have easily drawn a connection between the virtual world and the real world. Digital technologies are not only the daily tools of communication, information and entertainment for people but have become omnipresent and an integral part of people‟s lives. In today‟s digital world, the media can give you ideas, it can inspire you to do certain things and drive you to initiate what you see. The media controls the society and is capable of changing human behaviour, living style and moral thoughts and consequences. Media reflects in two ways i.e. positive as well as negative; as media does not produces the real happening of a world, rather creates a new world. The main aim of this research is to study the impact of media on human behaviour. It also aims to create difference between the virtual and the real world. This study would be able to bring out whether trending mass media does influence the youth‟s behaviour so as to decide whether to act in a manner parallel to the virtual world or see the practical-real aspect. And also aims to examine the effect of time period of accessing media on the human behaviour. The research design used is „Survey through Questionnaire‟ with an accidental sampling of 60 people between the age of 15-24 yrs (youth). The questionnaire includes questions pertaining to the subject‟s behaviour, influence, preference and thoughts. Everyday incidents relating to recent media trends is visible which leads people to commit acts which have been influenced by popular media and how such behaviour can be disastrous to human life. The newspaper articles shows the changes in human behaviour according to media which is also be studied to lay a base of media‟s psychological impact and further interpretation has been based according to the replies given to questionnaire as to what extent it can be influencing, harmful and how should media be utilised. The expectations from this research would be that the behavioural changes are brought by media in the youth and that these changes are quite significant which leads them to act accordingly.
The wider use of magnesium

agree that many of the questions on the use of transoesophageal echocardiography in atrial fibrillation will be addressed through secondary analyses of the ACUTE data. Anders Roijer and colleagues courageously used dalteparin as a single dose in patients with atrial fibrillation. There is no previously published safety data on the use of low molecular weight heparin in this patient population with transoesophageal echocardiography. Stellbrink and Hanrath correctly point out that there should be a randomized study addressing the role of lowmolecular-weight heparin in atrial fibrillation. We would like to point out that a randomized pilot study is now underway in the United States. The ACUTE II study is specifically designed to compare the feasibility and safety of a transoesophageal echocardiography guided lowmolecular-weight heparin (enoxaparin) approach compared to a transoesophageal echocardiography guided unfractionated heparin approach for patients in atrial fibrillation undergoing immediate cardioversion. The ongoing pilot study will follow 200 patients over a 5-week period. Safety outcomes include ischaemic stroke, transient ischaemic attack, systemic embolization, major and minor bleeding, cardioversion success, clinical haemodynamic instability, and mortality. Importantly, the study will measure relative length of hospital stay, patient quality of life/utility, and treatment costs. Savings from a reduction in hospital stay and improved quality of life are expected to offset the higher cost of the low-molecular-weight heparins in North America. The results of this pilot study will have further important clinical and economic implications for the antithrombotic management of patients with atrial fibrillation undergoing transoesophageal echocardiography guided cardioversion. R. D. MURRAY S. R. DEITCHER A. L. KLEIN Department of Cardiology, Department of Vascular Medicine,
The Cardiovascular Effects of Chronic Hypoestrogenism

In premenopausal women, the most severe menstrual dysfunction is amenorrhea and is associated with chronic hypoestrogenism. In postmenopausal women, the coincident hypoestrogenism observed is associated with a number of clinical sequelae related to cardiovascular health. Due to an observed cardioprotective effect of E2, persistently low E2 levels in amenorrheic (AM) athletes may confer deleterious effects on cardiovascular health. The incidence of amenorrhea among athletes is much greater than that observed among sedentary women. Recent data in AM athletes demonstrate impaired endothelial function, elevated lowand highdensity lipoprotein levels, reduced circulating nitrates and nitrites, and increased susceptibility to lipid peroxidation. An improvement in endothelial function has also been reported during the recovery of menstrual cyclicity in a small sample of previously AM athletes. Although no longitudinal studies exist, these findings are suggestive of increased risk of premature cardiovascular disease in AM athletes. These issues are explored and discussed in detail in this comprehensive review paper. Future research should focus on the presentation and progression of these adverse cardiovascular parameters in physically active women and athletes with hypoestrogenism to determine their effect on long-term health outcomes.
Physiological Roles of the Permeability Transition Pore

: Mitochondria are implicated in many important cellular functions covering the whole life cycle from mitochondrial biogenesis to cell death. Mitochondrial homeostasis is tightly regulated, and mitochondrial dysfunction is frequently associated with severe human pathologies (eg, cardiovascular diseases, cancer, and neurodegeneration). The permeability transition pore (PTP) is an unselective voltage-dependent mitochondrial channel. Despite the extensive use of electrophysiology, biochemistry, pharmacology, and genetic invalidation in mice, the molecular identity of PTP is still unknown. Nevertheless, PTP is central to mitochondrial vital functions and can play a lethal role in many pathophysiological conditions. This review recapitulates the current knowledge of the various modes of conductance of the PTP channel and discusses their implication in the physiological roles of PTP and their regulation. Based on its involvement in normal physiology and human pathology, a better understanding of this channel and its roles remains a major goal for basic scientists and clinicians. ( Circ Res . 2012;111:1237-1247.)