Miracle-dz/UniFAR-FTUs huggingface dataset:
Adipocyte‐derived extracellular vesicles as new communication signals in the regulation of food intake

Mechanisms of cross organ communication is vital for our bodies to maintain homeostasis. Secreted peptides, proteins and the autonomic nervous system have been the major regulators in metabolic adaptation. During the last decade significant scientific evidence has accumulated that extracellular vesicles (EVs), secreted by all cells, are involved cellular signaling [1, 2]. The EVs consists of different types, e.g. exosomes from the endosomal pathway, microvesicles from the cell surface and apoptotic bodies. They are 30-2000 nm in size, loaded with proteins, lipids or nucleic acids and have a wide range of actions/functions in tissue repair, immunity, cardiometabolic diseases and carcinogenesis [3]. Pathological roles have also been recently described in insulin resistance [4, 5]. EVs are able to interact with the target cells via special receptors (e.g. integrins, proteoglycans), or internalized via phagocytosis or membrane fusion.
Body sensor network encryption and team user authentication scheme based on electrocardiogram detector

Body sensor network (BSN)/wireless body area networks (WBANs) is one of the essential aspects of the Internet of Things (IoT), which is possible to track the patient's essential biological and cognitive data through wearable sensors. The WBAN is easily accessible due to open sources; data security and privacy should be maintained throughout the communication characteristics. Due to the advancement of technology, BSN is restricted in a wide range of clinical applications. BSN is used to monitor the physiological characteristics continuously. The data can be easily traced by the attackers where the fingerprint scanners obtained can be used for the user authentication because of its wireless communication. This paper proposes a body sensor network encryption and user authentication (BSN‐EUA) scheme based on the ECG detector. BSN‐EUA scheme is used to provide the fingerprint scanners for user authentication, and all the activities regarding the health of a person are recorded on the mobile phone. The electrocardiogram's (ECG) descriptive characteristics are used throughout the authentication process as a recognizable fingerprint parameter. Quick community security protocols are then provided across all certified sensors where minor adjustments are needed to update the key generation mechanism on the sensor's side. Evaluation results show that the methodology suggested could reach the required security requirements and avoid several threats.
Instrumentation for multiaxial mechanical testing of inhomogeneous elastic membranes

This thesis presents the design, development, and construction of an instrument for biaxial mechanical testing of inhomogeneous elastic membranes. The instrument incorporates an arrangement of linear motion stages for applying arbitrary deformation profiles on the material under test, purpose-built two-axis force transducers for highresolution measurement of applied loads, and a digital imaging system for full-field strain measurement. The components described herein provide the foundation for a sophisticated biaxial testing platform for determining the mechanical properties of anisotropic, inhomogeneous membrane materials. Thesis Supervisor: Ian W. Hunter Title: Hatsopoulos Professor of Mechanical Engineering Professor of Bioengineering
Utility of a Reverse Phase Protein Array to Evaluate Multiple Biomarkers in Diffuse Large B‐Cell Lymphoma

Diffuse large B‐cell lymphoma (DLBCL), the most common non‐Hodgkin lymphoma, is a heterogeneous lymphoma with different clinical manifestations and molecular alterations, and several markers are currently being measured routinely for its diagnosis, subtyping, or prognostication by immunohistochemistry (IHC). Here, the utility of a reverse‐phase‐protein‐array (RPPA) as a novel supportive tool to measure multiple biomarkers for DLBCL diagnosis is validated.
Sedative Use of Dexmedetomidine vs. Propofol after Cardiac Surgery A Critical Review and Meta-Analysis.

Background The efficacy and safety of dexmedetomidine in sedation for postoperative cardiac surgeries are controversial when compared to propofol. Methods A computerized search on Medline, EMBASE, Web of Science, and Agency for Healthcare Research and Quality databases was performed through July 2019. Trials evaluating the efficacy of dexmedetomidine versus propofol in the sedation of postoperative cardiac surgery patients were selected. The primary study outcomes were divided into time-dependent (mechanical ventilation time; time to extubation; length of stay in the intensive care unit and the hospital) and non-time dependent (delirium, bradycardia, and hypotension). Results Our final analysis included 11 RCTs published between 2003 and 2019 and involved a total of 1184 patients. Time to extubation was significantly reduced in the dexmedetomidine group (Standardized Mean Difference (SMD) = -0.61, 95% Confidence Interval (CI): -1.06 to -0.16, p=0.008), however no difference in mechanical ventilation time was observed (SMD= -0.72, 95% CI: -1.60 to 0.15, N.S.). Moreover, the dexmedetomidine group showed a significant reduction in Intensive Care Unit length of stay (SMD= -0.70, 95% CI: -0.98 to -0.42, p=0.0005) this did not translate into a reduced hospital length of stay (SMD= -1.13, 95% CI: -2.43 to 0.16, N.S). For non-time dependent factors: incidence of delirium was unaffected between groups (OR: 0.68, 95% CI: 0.43 to 1.06, N.S.), while the propofol group of patients had higher rates of bradycardia (OR: 3.39, 95% CI: 1.20 to 9.55, p=0.020) and hypotension (OR: 1.68, 95% CI: 1.09 to 2.58, p=0.017). Conclusion Despite the ICU time advantages afforded by dexmedetomidine over propofol, the former does not contribute to an overall reduction in hospital length of stay or an overall improvement in postoperative outcomes of heart valve surgery and CABG patients. Additionally, time-dependent outcomes are affected by several confounding factors, and more efforts are needed to analyze factors that could affect sedation in post-cardiac surgery patients and choose unbiased outcomes.
Accounting for Managers

This title presents the basics you need to know about how money is tracked - and accounted for - in your organization. How much money will this project cost? Where is it coming from? Can my department get more? If not, why? As a manager, accounting will play a hand in virtually every decision you make. "Accounting for Managers" explains the critical accounting concepts you need to understand in this vital area, and then demonstrates their implementation and application in everyday business.This newest addition to McGraw-Hill's popular, hands-on "Briefcase Books" series gives you the insights you need to track how money flows through and fuels your organization, including: how to speak - and understand - the language of business accounting; financial relationships between and among everyday business activities; and, next-generation systems including Balanced Scorecard, Just-in-Time, and more. Before you truly understand a business - and how to succeed in that business - you must understand its cash flow. Let "Accounting for Managers" give you the knowledge you need to talk intelligently about accounting issues and questions and, just as important, enhance your productivity and value to both your organization and your career. "Briefcase Books" are written specifically for today's busy manager. Each book features eye-catching icons, checklists, and sidebars to guide managers step-by-step through everyday workplace situations. Look for these innovative design features to help you navigate through each page: [Key Terms icon] Clear definitions of key accounting terms and jargon; [Smart Managing icon] How accounting smarts can help your department - and career; [Tricks of the Trade icon] How-to hints for efficient, effective use of accounting; [Mistake proofing icon] Advice for minimizing errors when "working the numbers"; [Caution icon] Warning signs of small accounting errors that could become disastrous; [For Example icon] Examples from a variety of companies, large and small; and, [Tools icon] Boxes where you'll find specific accounting tools and procedures.
Comparison of sprint interval and continuous endurance training on oxidative stress and antioxidant adaptations in young healthy adults

Background: Different intensities of exercise induce varying levels of reactive oxygen species, causing oxidative stress. However, regular physical training enhances the antioxidant system and protects tissues by oxidative stress. This study aimed to investigate the difference in markers between time-efficient low-volume high intensity interval (sprint interval training: SIT) and traditional high-volume low-intensity methods (continuous endurance training: CET) regarding oxidative stress and antioxidant levels. Material and methods: Fifteen male volunteers were divided into two groups according to their VO2max levels. The SIT program consisted of 4–6 Wingate all-out sprints with a 4.5 min recovery, while CET consisted of 30–50 min cycling at 60% VO2max for seven weeks. Total oxidant status (TOS), total antioxidant status (TAS), plasma malondialdehyde (MDA) and glutathione peroxidase (GSH-Px) levels were examined in pre and post-intervention. Results: Increases in GSH-Px (30% vs. 55%), TOS (33% vs. 18%) and a significant decrease in MDA (8.6%, p<0.003; 6.8%, p<0.016) in CET and SIT were observed, respectively. By contrast, TAS decreased (62%) after CET and increased (17%) after SIT. No significant differences in these parameters were reported after the training period between SIT and CET groups. Conclusions: SIT was suggested as a safe exercise model to improve general health and the performance of traditional CET.
The re-dating of some Scottish specimens by the Oxford Radiocarbon Accelerator Unit (ORAU)

The purpose of this note is to alert readers to the fact that some AMS dates determined by ORAU on Scottish material between 2000 and 2002 have had to be deleted and re-determined, because of a problem in the ultrafiltration system used to pretreat bone samples during that period (see C Bronk Ramsey, T Higham, A Bales and R Hedges 2004, Improvements in the pretreatment of bone at Oxford, Radiocarbon 46(1), 155–63, for details). In many cases it has been possible to undertake the re-dating using left over material from the original (unprocessed) samples; in other cases, re-sampling will be necessary. Lists of both sets of material are appended here, and readers are requested to use only the new dates, and to delete the old versions.
A COMPARATIVE ANALYSIS OF RISK PREFERENCE ELICITATION PROCEDURES USING MAIL SURVEY RESULTS

Very little work has been done on the issue of whether there is consistency across alternative risk preference elicitation procedures in a mail survey context. A mail survey of Louisiana and South Dakota cow-calf producers was conducted to determine if there is rank order consistency. Six procedures were compared. A statistical comparison across ordinal rankings indicated very little consistency across elicitation procedures. Probit analysis was also conducted. We regressed economic, lifestyle, and social attributes on the ordinal rankings from five of the six elicitation procedures. Again, there was a lack of consistency across elicitation procedure with respect to which behavioral attributes best explained variation in a particular elicitation procedure’s ordinal ranking. The conclusion drawn from the study is: The simpler the risk elicitation procedure used in a mail survey the better.
Iron Losses in Electrical Machines - Influence of Material Properties, Manufacturing Processes, and Inverter Operation

As the major electricity consumer, electrical machines play a key role for global energy savings. Machine manufacturers put considerable efforts into the development of more efficient electrical machines for loss reduction and higher power density achievements. A consolidated knowledge of the occurring losses in electrical machines is a basic requirement for efficiency improvements.This thesis deals with iron losses in electrical machines. The major focus is on the influences of the stator core magnetic material due to the machine manufacturing process, temperature influences, and the impact of inverter operation.The first part of the thesis gives an overview of typical losses in electrical machines, with focus put on iron losses. Typical models for predicting iron losses in magnetic materials are presented in a comprehensive literature study. A broad comparison of magnetic materials and the introduction of a new material selection tool conclude this part.Next to the typically used silicon-iron lamination alloys for electrical machines, this thesis investigates also cobalt-iron and nickel-iron lamination sheets. These materials have superior magnetic properties in terms of saturation magnetization and hysteresis losses compared to silicon-iron alloys.The second and major part of the thesis introduces the developed measurement system of this project and presents experimental iron loss investigations. Influences due to machine manufacturing changes are studied, including punching, stacking and welding effects. Furthermore, the effect of pulse-width modulation schemes on the iron losses and machine performance is examined experimentally and with finite-element method simulations.For nickel-iron lamination sheets, a special focus is put on the temperature dependency, since the magnetic characteristics and iron losses change considerably with increasing temperature. Furthermore, thermal stress-relief processes (annealing) are examined for cobalt-iron and nickel-iron alloys by magnetic measurements and microscopic analysis.A thermal method for local iron loss measurements is presented in the last part of the thesis, together with experimental validation on an outer-rotor permanent magnet synchronous machine.
Activity of Aerosolized Levofloxacin against Burkholderia cepacia in a Mouse Model of Chronic Lung Infection

Burkholderia cepacia complex is an opportunistic pathogen capable of causing chronic pulmonary infections. These studies were conducted to demonstrate the activity of aerosolized levofloxacin in a chronic mouse lung infection model caused by B. cepacia isolates from patients with cystic fibrosis. ABSTRACT Burkholderia cepacia complex is an opportunistic pathogen capable of causing chronic pulmonary infections. These studies were conducted to demonstrate the activity of aerosolized levofloxacin in a chronic mouse lung infection model caused by B. cepacia isolates from patients with cystic fibrosis. Treatment with aerosolized levofloxacin for 4 days produced at least 1 log CFU of bacterial killing against all strains tested, suggesting possible utility in the treatment of lung infections caused by B. cepacia isolates.
Watch what I do: programming by demonstration

Part 1 Systems: Pygmalion tinker a predictive calculator rehearsal world smallStar peridot metamouse TELS eager garnet the Turvy experience chimera the geometer's sketchpad tourmaline a history-based macro by example system mondrian triggers the AIDE project. Part 2 Components: a history of editable graphical histories graphical representation and feedback in a PBD system PBD invocation techniques a system-wide macro facility based on aggregate events making programming accessible to visual problem solvers using voice input to disambiguate intent. Part 3 Perspectives: characterizing PBD systems demonstrational interfaces just-in-time programming.
Analisis Data Magnetik Untuk Mengetahui Struktur Bawah Permukaan Daerah Manifestasi Air Panas di Lereng Utara Gunungapi Ungaran

Kondisi struktur geologi gunungapi Ungaran yang komplek dan terdapatnya manifestasi airpanas di lereng utara gunungapi Ungaran di Nglimut dan Medini mendorong dilakukannya survei geofisika dengan metode magnetik. Penelitian bertujuan untuk mengetahui kondisi struktur bawah permukaan di daerah ini dan mengetahui struktur yang mengontrol terjadinya manifestasi airpanas tersebut. Penelitian dilaksanakan selama l0 hari dengan luas area 2 km x 3 km dan spasi pengukuran 100 mmenggunakan PPM dengan gradio dan GPS Trimble 4600 LS sebagai alat pengukur posisi. Pemrosesan data dimulai dengan koreksi IGRF dan koreksi variasi harian untuk mendapatkan anomali medan magnet total. Kemudian dilakukan reduksi ke bidang datar di ketinggian 867 meter di atas sferoida referensi, kontinuasi ke atas sampai ketinggian 1300 m di atas sferoida referensi dan pemisahan anomali lokal dan regional. Hasilnya kemudian direduksi ke kutub, ditransformasi psedogravitasi serta dicari gradien horisontalnya. Interpretasi kualitatif dilakukan dengan menganalisa kontur gradient vertikal medan magnet total, kontur anomali medan magnet total yang telah direduksi ke kutub dan hasil tranformasi pseudogravitasi serta kontur gradien horizontal. Interpretasi kuantitatif dilakukan dengan pemodelan benda anomali menggunakan program Mag2DC for windows. Hasil dari interpretasi kualitatif adalah posisi horizontal dari benda penyebab anomali, yaitu berada di antara manifestasi airpanas Nglimut dan Medini serta diketahui bahwa benda penyebab anomali memanjang dengan arah baratlaut-tenggara yang kemudian diinterpretasikan sebagai sesar dan batas batuan. Hasil dari interpretasi kuantitatif adalah model struktur geologi berupa sesar turun pada endapan piroklastik dan sesar turun pada batas batuan antara endapan piroklastik (k = 0,0269 emu) dengan basal (k = 0,001 emu). Manifestasi airpanas di daerah Nglimut dan Medini dikontrol oleh adanya sesar turun yang menjadi zona lemah sehingga mudah diterobos oleh air panas yang berasal dari reservoar panasbumi gunungapi Ungaran. Penerobosan airpanas ini menyebabkan penurunan nilai suseptibilitas endapan piroklastik menjadi 0,0020 emu.
In vitro Antibacterial, Antioxidant and Mechanism of Antifungal Activities of Selected Indian Traditional Plants against Human Oral Microbes

et al. : Antimicrobial Activity of Traditional Plants against Oral Pathogens Morus alba, Asparagus racemosus and Murraya koenigii are commonly used in Indian traditional medicines for the various ailments. The plant extracts were analysed for antibacterial, antifungal and antioxidant activities and their mechanism of action towards human oral fungal pathogens. In the present study, methanol extracts were obtained using a soxhlet apparatus and microbes were obtained from microbial type culture collection and gene bank, Pune. The total phenol and flavonoid were found to be high in Murraya koenigii (2.77 mg gallic acid equivalents/g) and Morus alba (160 µg Quercetin equivalent/mg) respectively. The maximum radical scavenging activity was shown by Murraya koenigii in 2,2-diphenylpicrylhydrazyl (71 %) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (82.57 %) methods. The maximum antibacterial and antifungal activities were observed in Asparagus racemosus towards Lactobacillus acidophilus (23 mm) and Candida krusei (10 mm) respectively. The minimum inhibitory concentration was also determined. The target of antifungal activity of Asparagus racemosus towards Candida krusei was not cell wall whereas targets the cell membrane which is confirmed by sorbitol assay, transmission electron microscopy and flow cytometry. This research can be used as a base to find the active components responsible for antibacterial, antifungal and antioxidant activities.
Modern Navigation, Guidance, And Control Processing

This work offers detailed information on the modelling, design, analysis, simulation and evaluation (MDASE) of advanced navigation, guidance and control (NGC) systems. The book emphasizes the practical applications of advanced systems and discusses approaches to designing. The book also includes information about the status of major aerospace programmes, as well as trends in aerospace technology; covers a range of applications from military and commercial aircraft to spacecraft and missile and weapon systems; offers practical tools and approaches for solving real-world aerospace engineering problems; and provides a detailed evaluation of modern analysis techniques and advanced control system design.
LEARNING FROM AUTOMATION SURPRISES AND "GOING SOUR" ACCIDENTS. IN: COGNITIVE ENGINEERING IN THE AVIATION DOMAIN

The paper summarizes the pattern that has emerged from research incident reports, and accident investigation. It attempts to understand why problems arise and points to new investment strategies that can help dealing with the perceived human error problem, make automation more of a team player, and maintain and improve safety. Broad patterns have been identified behind the details of particular incidents and accidents; also recognized is the need to better guard against the kind of incident where people and the automation seem to mismanage a minor occurrence or nonroutine situation into larger trouble - the going sour scenario. This scenario is a symptom of breakdowns in coordination between people and machines that in turn are a symptom of overall system complexity, at both operational and organizational levels.
Patents in Germany and Europe: Procurement, Enforcement and Defense - An International Handbook

List of Tables List of Figures Preface List of Abbreviations Chapter 1 Why Germany? Chapter 2 Sources of Law Chapter 3 Structure of Legal System Chapter 4 Forms of Patent Protection: Background on Prosecution Chapter 5 Patentability Standards Chapter 6 Opposition Proceedings Chapter 7 Nullity Actions Chapter 8 Pre-Suit Considerations and Infringement Trial Chapter 9 Preliminary Injunction Proceedings Chapter 10 Claim Construction and Infringement Chapter 11 Discovery and Evidence Taking Chapter 12 Damages Chapter 13 Inventorship and Ownership Chapter 14 Customs Actions Chapter 15 Budgeting a Patent Enforcement Case Chapter 16 Samples Chapter 17 Legal Texts Chapter 18 Key Differences between U.S. and European Patent Laws Index
Influence of autoinducer 2 (ai-2) and ai-2-like inhibitors generated from ground beef on escherichia coli o157:h7 protein expression

Influence of Autoinducer 2 (AI-2) and AI-2-like Inhibitors Generated from Ground Beef on Escherichia coli O157:H7 Protein Expression. (May 2008) Kamleshkumar Arvindkumar Soni, B. Tech., SMC College of Dairy Science; M.S., Texas A&M University Chair of Advisory Committee: Dr. Suresh D. Pillai Autoinducer 2 (AI-2) molecules produced by bacterial cells are thought to be involved in controlling a variety of bacterial cellular processes by coordinated gene and protein expression. Previous work in our laboratory has shown that ground beef contains compounds that can interfere with AI-2-mediated bioluminescence expression in Vibrio. harveyi. The underlying hypothesis of this work was that AI-2 molecules affect the protein expression in Escherichia coli O157:H7 and AI-2 inhibitory molecules negate the influence of AI-2 molecules. The main objectives of this study were to identify, characterize, and isolate the factors responsible for inhibition of AI-2 molecules from ground beef extracts, elucidate the role of LuxS/AI-2 cell signaling system in E. coli O157:H7 protein expression, and determine if inhibitory factors present in ground beef extract can negate the influence of AI-2 molecules on the protein expression. Using a solvent extraction procedure and gas chromatography analysis, AI-2 inhibitory factors present in ground beef extracts were identified as both medium and long chain fatty acids. When identified fatty acids were tested at different concentrations for AI-2