Miracle-dz/UniFAR-FTUs huggingface dataset:
Combinational Effect of 5-Flourouracil and Resveratrol against N-Nitroso-N-methyl urea Induced Colorectal Cancer

Background: colorectal cancer is considered to be the third most common cause of deaths in both men and women. The incidence of colorectal cancer cases has been rising at an alarming rate. In most cases, colon cancer treatment involves chemotherapy. However, toxicity and tumor cell drug resistance are outstanding obstacles to this treatment. Scientific studies suggested that combining certain chemotherapy treatments with specific antioxidants at defined dosages can improve drug efficacy or may reduce side effects severity.5-Fluorouracil, which is used in the treatment of breast, stomach and pancreatic cancer, remains the cornerstone of CRC treatment, although widely used in combination with several other drugs. Many effective drugs, including those actually used for cancer treatment, have been developed from botanical sources. Resveratrol is a pleiotropic phytochemical which is belong to the stilbene family. Although, it is only significantly present in grape products. Many preclinical studies investigated its anticancer properties in a plethora of cellular and animal models. Aim of the work: in the present study, the anticancer effects of Resveratrol alone or combined with 5-Fu were assessed on experimentally induced colorectal cancer in rats. Results: the results of this study indicated that RES had a better therapeutic effect against N-methylnitrosourea induced colorectal cancer than 5-Fu alone and when in combination with each other they diminished the cytotoxic effect of 5-Fu and enhanced normal histological appearance of colon tissue, which could be a promising alternative for resistant colorectal cancer. However, the exact mechanisms involved needs to be further explored. Conclusion: our results suggested that both natural compounds could be in the future a possible alternative to enhance the efficiency of 5-Fu in resistant colon cancer cells. This study supports the potential of plant extracts as source of bioactive compounds with biomedical applications.
Self-Efficacy, Psychological Flexibility, and Basic Needs Satisfaction Make a Difference: Recently Graduated Psychologists at Increased or Decreased Risk for Future Health Issues

The transition from university to working life appears a critical period impacting human service workers’ long-term health. More research is needed on how psychological factors affect the risk. We aimed to investigate how subgroups, based on self-efficacy, psychological flexibility, and basic psychological needs satisfaction ratings, differed on self-rated health, wellbeing, and intention to leave. A postal survey was sent to 1,077 recently graduated psychologists in Sweden (≤3 years from graduation), response rate 57.5%, and final sample 532 (75% women and 23% men). A hierarchical cluster analysis resulted in a satisfactory eight-cluster solution. We identified two at-risk subgroups, displaying the lowest scores on health and wellbeing, and one potential low-risk subgroup with the highest ratings on said variables. The “Low risk? ” group rated high on all three psychological constructs, a positive transition to working life, a work environment where resources balanced relatively high emotional demands, good health, and wellbeing. Almost the complete opposite ratings characterized the potential risk groups. “Quitting? ” scored significantly higher than “Getting sick? ” on self-efficacy and psychological flexibility as well as actively seeking new employment and reporting daily thoughts on leaving the profession. We suggest that a combination of low self-efficacy and psychological flexibility could increase the risk of individuals staying despite suboptimal working conditions. With combined higher self-efficacy and psychological flexibility, individuals in similar circumstances appear more inclined to quit. We conclude that the ways recently graduated psychologists rate their self-efficacy, psychological flexibility, and basic needs satisfaction appear to be reflected in their self-rated health and wellbeing.
Panoramic: A package for constructing eukaryotic pan‐genomes

The study of intraspecific genomic variation in eukaryotic species has been the focus of numerous genome resequencing projects in recent years. One emerging approach for the analysis of intraspecific diversity uses the concept of a pan‐genome, which theoretically represents the full set of genomic sequences and coding genes from all individuals of a given species. This approach has many advantages over reference‐based methods and has been successfully applied to study both prokaryotic and eukaryotic species. However, the process of pan‐genome construction still presents considerable scientific and technical challenges, especially for eukaryotic species with large and complex genomes. Although general approaches for the construction of pan‐genomes have been devised, currently available software tools implement only certain modules of the entire computational procedure. Therefore, each pan‐genome project requires the development of tailored analysis pipelines, thus complicating and prolonging the process and impairing research reproducibility and comparison across studies. Here, we present Panoramic, a software package for the automatic construction of eukaryotic pan‐genomes. Panoramic takes raw sequencing reads as input and applies two alternative approaches for pan‐genome construction. Panoramic makes pan‐genome construction a considerably easier task by providing simple user interface and efficient data processing algorithms. We demonstrate the use of Panoramic by constructing the pan‐genome of the model plant species Arabidopsis thaliana from sequencing data of 20 diverse ecotypes.
Effects of Chelating Agents on Protein, Oil, Fatty Acids, and Minerals in Soybean Seed

Soybean seed is a major source of protein and oil for human diet. Since not much information is available on the effects of chelating agents on soybean seed composition constituents, the current study aimed to investigate the effects of various chelating agents on soybean [(Glycine max (L.) Merr. )] seed protein, oil, fatty acids, and mineral concentrations. Three chelating agent [citric acid (CA), disodium EDTA (DA), and Salicylic acid (SA)] were applied separately or combined with ferrous (Fe2+) ion (CA + Fe, EDTA + Fe, and SA + Fe) to three-week-old soybean plants. After application, the plants were allowed to grow until harvest maturity under greenhouse conditions. The results showed that CA, DA, SA, and Fe resulted in an increase of oleic acid from 13.0% to 33.5%. However, these treatments resulted in a decrease of linolenic acid from 17.8 to 31.0%. The treatments with CA and SA applications increased protein from 2.9% to 3.4%. The treatments DA + Fe and SA + Fe resulted in an increase in oil from 6.8% to 7.9%. Seed macro- and micro-elements were also altered. The results indicated that the CA, SA, DA, and Fe treatments can alter seed protein, oil, fatty acids, and mineral concentrations. Further studies are needed for conclusive results.
BIO-CHEMICAL CHANGES OF NUTRIENTS IN RICE PLANT UNDER SODIC SOILS

This paper presents the chemical changes in various nutrients in rice plant under sodic soil. The nutrients were applied on soil test recommendation basis. The sodic soil was low in several nutrients like available nitrogen, available phosphorus (P2O5,), sulphur, zinc, manganese, carbon and available potassium (K2O) was medium. pH and EC of soil was 9.0 and 0.29 dSm -1 , respectively. The uptake values of all nutrients were the lowest in control and highest in NPKS+Zn+Mn treatment during both the years. Sequential additions of different nutrients also gave significant increase in uptake. For obtaining the highest yields of dry matter 87.60 and 90.60 Qha 1 were required first and second years. The mean total uptake of N, P, K, S, Zn and Mn was 66.92 Kg, 25.04 Kg, 79.70 Kg, and 16.30 Kg, 232.90 g and 337.70 g ha -1 respectively was taken up by the plant. The uptake value of the above mentioned nutrients were calculated on the basis biological yield and concentration of the nutrients. The sodic soil of experimental field was found deficient in almost all the nutrients tested under missing nutrient technique precisely in a site specific management trial, satisfactory yield could be obtained with the addition of N, P, K, S, Zn and Mn on soil test recommendation basis.
Enantioenriched Positive Allosteric Modulators Display Distinct Pharmacology at the Dopamine D1 Receptor

(1) Background: Two first-in-class racemic dopamine D1 receptor (D1R) positive allosteric modulator (PAM) chemotypes (1 and 2) were identified from a high-throughput screen. In particular, due to its selectivity for the D1R and reported lack of intrinsic activity, compound 2 shows promise as a starting point toward the development of small molecule allosteric modulators to ameliorate the cognitive deficits associated with some neuropsychiatric disease states; (2) Methods: Herein, we describe the enantioenrichment of optical isomers of 2 using chiral auxiliaries derived from (R)- and (S)-3-hydroxy-4,4-dimethyldihydrofuran-2(3H)-one (d- and l-pantolactone, respectively); (3) Results: We confirm both the racemate and enantiomers of 2 are active and selective for the D1R, but that the respective stereoisomers show a significant difference in their affinity and magnitude of positive allosteric cooperativity with dopamine; (4) Conclusions: These data warrant further investigation of asymmetric syntheses of optically pure analogues of 2 for the development of D1R PAMs with superior allosteric properties.
Variation in labour skills and offshoring across time zones

The paper extends Dei (2010) to check the role of time zone difference on offshoring of service tasks when the quality of workers varies between the partner countries. We frame a model where partner countries are located in non-overlapping time zones, and the skill level of the partner country workers is lower than that of the domestic workers. In our model, service production is divided into two sequential stages, and output is a supermodular function of the skill of workers and time. The problem of the service producers is to choose between domestic production and offshoring. Domestic production employs high-quality skilled labours but the time management is inefficient. On the other hand, offshoring to a non-overlapping time zone helps a firm to work round the clock, but the low quality of skilled labour lowers the output, though they cost less. In such a framework, we check under what conditions offshoring is beneficial. The analysis provides a condition where firms decide to offshore through a tradeoff between time and skill. We observe that the lesser of 24 hours domestic production use, the lower will be the threshold of acceptable skill level. Results show that offshoring to a different time zone is beneficial even when the complexity of stages of production vary. However, it is observed that only the relatively less-critical task is offshored. We further observe that availability of domestic lowquality labour does not benefit the firm, but foreign low-quality labour can be beneficially utilized through time-zone exploitation. JEL Classification: F1; F23; J24; L23; L86
Non-Destructive Biomass Estimation in Mediterranean Alpha Steppes: Improving Traditional Methods for Measuring Dry and Green Fractions by Combining Proximal Remote Sensing Tools

The Mediterranean region is experiencing a stronger warming effect than other regions, which has generated a cascade of negative impacts on productivity, biodiversity, and stability of the ecosystem. To monitor ecosystem status and dynamics, aboveground biomass (AGB) is a good indicator, being a surrogate of many ecosystem functions and services and one of the main terrestrial carbon pools. Thus, accurate methodologies for AGB estimation are needed. This has been traditionally done by performing direct field measurements. However, field-based methods, such as biomass harvesting, are destructive, expensive, and time consuming and only provide punctual information, not being appropriate for large scale applications. Here, we propose a new non-destructive methodology for monitoring the spatiotemporal dynamics of AGB and green biomass (GB) of M. tenacissima L. plants by combining structural information obtained from terrestrial laser scanner (TLS) point clouds and spectral information. Our results demonstrate that the three volume measurement methods derived from the TLS point clouds tested (3D convex hull, voxel, and raster surface models) improved the results obtained by traditional field-based measurements. (Adjust-R2 = 0.86–0.84 and RMSE = 927.3–960.2 g for AGB in OLS regressions and Adjust-R2 = 0.93 and RMSE = 376.6–385.1 g for AGB in gradient boosting regression). Among the approaches, the voxel model at 5 cm of spatial resolution provided the best results; however, differences with the 3D convex hull and raster surfacebased models were very small. We also found that by combining TLS AGB estimations with spectral information, green and dry biomass fraction can be accurately measured (Adjust-R2 = 0.65–0.56 and RMSE = 149.96–166.87 g in OLS regressions and Adjust-R2 = 0.96–0.97 and RMSE = 46.1–49.8 g in gradient boosting regression), which is critical in heterogeneous Mediterranean ecosystems in which AGB largely varies in response to climatic fluctuations. Thus, our results represent important progress for the measurement of M. tenacissima L. biomass and dynamics, providing a promising tool for calibration and validation of further studies aimed at developing new methodologies for AGB estimation at ecosystem regional scales.
The occurrence of repairs in Burmese telephone conversations between Thai call center operators and Burmese customers

This research aims to analyze the types, frequency and devices of repair that occurred in Burmese telephone conversations between Thai call center operators and Burmese customers. The data consist of 80 conversations recorded from a call center. The study is based on the framework of Schegloff, Jefferson and Sacks (1977). The research reveals that there were three types of repairs, which included 1) self-initiated and self-repair, 2) other-initiated and self-repair, and 3) other-initiated and other-repair. The most frequently used types were other-initiated and self-repair, and self-initiated and self-repair, respectively. On the other hand, it found that Burmese customers started repair initiation more frequently than Thai call center operators. The results of other-initiated repair devices show that there were six devices: 1) A short word (.) ʃiɴ ‘Yes? , I beg your pardon, what did you say? ’, 2) The questions: (.) ba lέ ‘What? ’, bέ lo lέ ‘How? ’, 3) Repetition as a part of the trouble–source turn plus a question: noun sho da ba lέ ‘What does ‘…’ mean? ’, 4) Repetition as part of the trouble-source with rising intonation, 5) “You Mean” plus a possible understanding of prior turn: statement plus (.) di lo la ‘Is it like this’, and 6) Request: (.) pjɔ pe ba nɔ ‘Please tell me’. In addition, combined devices were also found in this study.
Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes

Significance Current acute myeloid leukemia (AML) risk assessment relies on cytogenetics and gene-sequencing studies but is imperfect, especially for patients with normal karyotypes and intermediate risk. To understand factors associated with excellent responses in these patients, we compared genetic and transcriptional data from patients with first remissions lasting more than 5 y after chemotherapy, to matched controls with first remissions lasting fewer than 2 y. AML cells from patients with early relapse displayed an immunosuppressive phenotype that blocked CD4 T cell activation via the T cell receptor; the long first-remission AML cells did not display this phenotype. Inhibiting LAG3 reversed this immunosuppression in most tested cases. This immunosuppressive phenotype may help to stratify risk of relapse at presentation, and outcomes. Acute myeloid leukemia (AML) patients rarely have long first remissions (LFRs; >5 y) after standard-of-care chemotherapy, unless classified as favorable risk at presentation. Identification of the mechanisms responsible for long vs. more typical, standard remissions may help to define prognostic determinants for chemotherapy responses. Using exome sequencing, RNA-sequencing, and functional immunologic studies, we characterized 28 normal karyotype (NK)-AML patients with >5 y first remissions after chemotherapy (LFRs) and compared them to a well-matched group of 31 NK-AML patients who relapsed within 2 y (standard first remissions [SFRs]). Our combined analyses indicated that genetic-risk profiling at presentation (as defined by European LeukemiaNet [ELN] 2017 criteria) was not sufficient to explain the outcomes of many SFR cases. Single-cell RNA-sequencing studies of 15 AML samples showed that SFR AML cells differentially expressed many genes associated with immune suppression. The bone marrow of SFR cases had significantly fewer CD4+ Th1 cells; these T cells expressed an exhaustion signature and were resistant to activation by T cell receptor stimulation in the presence of autologous AML cells. T cell activation could be restored by removing the AML cells or blocking the inhibitory major histocompatibility complex class II receptor, LAG3. Most LFR cases did not display these features, suggesting that their AML cells were not as immunosuppressive. These findings were confirmed and extended in an independent set of 50 AML cases representing all ELN 2017 risk groups. AML cell–mediated suppression of CD4+ T cell activation at presentation is strongly associated with unfavorable outcomes in AML patients treated with standard chemotherapy.
Untangling Classification Methods for Melanoma Skin Cancer

Skin cancer is the most common cancer in the USA, and it is a leading cause of death worldwide. Every year, more than five million patients are newly diagnosed in the USA. The deadliest and most serious form of skin cancer is called melanoma. Skin cancer can affect anyone, regardless of skin color, race, gender, and age. The diagnosis of melanoma has been done by visual examination and manual techniques by skilled doctors. It is a time-consuming process and highly prone to error. The skin images captured by dermoscopy eliminate the surface reflection of skin and give a better visualization of deeper levels of the skin. However, the existence of many artifacts and noise such as hair, veins, and water residue make the lesion images very complex. Due to the complexity of images, the border detection, feature extraction, and classification process are challenging. Without a proper mechanism, it is hard to identify and predict melanoma at an early stage. Therefore, there is a need to provide precise details, identify early skin cancer, and classify skin cancer with appropriate sensitivity and precision. This article aims to review and analyze two deep neural network-based classification algorithms (convolutional neural network, CNN; recurrent neural network, RNN) and a decision tree-based algorithm (XG-Boost) on skin lesion images (ISIC dataset) and find which of these provides the best classification performance metric. Also, the performance of algorithms is compared using six different metrics—loss, accuracy, precision, recall, F1 score, and ROC.
Professional quality of life in nurses on the frontline against COVID‐19

Abstract Aims This study aimed to investigate professional quality of life (ProQOL) in nurses who were fighting against COVID‐19 in Wuhan and its related factors. Background COVID‐19 epidemic is a major threat to public health. Frontline nurses have engaged in infection prevention and control, isolation, containment and public health. However, available data on ProQOL in these nurses are limited. Methods From 15 to 21 March 2020, the Chinese version of ProQOL was utilized to survey a total of 102 nurses through an electronic questionnaire. The stepwise regression analysis was performed to determine which factors (e.g. demographic and work‐related factors) were related to ProQOL. Results The scores of compassion satisfaction (CS), burnout (BO) and secondary traumatic stress (STS) were 38.09 ± 5.22, 21.77 ± 4.92 and 20.75 ± 6.27, respectively. The STS and CS scores were higher than the critical value. None of the nurses reported a low level of CS or a high level of BO and STS. Nurses' ProQOL was related to working hours, workload, job satisfaction and salary satisfaction. Conclusions Nurses who were fighting against COVID‐19 had better CS and BO, whereas STS was relatively worse. Nurses who worked for long hours had more severe STS. BO of nurses with heavy workload and dissatisfaction with their salary was more severe. Nurses who were unsatisfied with their job had poor CS. Implications for Nursing Management It is believed that these results may help nurse managers to improve ProQOL of nurses who were fighting against COVID‐19 by minimizing working hours, reducing workload and improving job satisfaction and rewards.
Taxonomic implications of describing a new species of Loimia (Annelida, Terebellidae) with two size-dependent morphotypes

We describe Loimia davidi sp. nov. (Annelida, Terebellidae) from São Miguel Island (Azores). It resembles Loimia gigantea (Montagu, 1819) (English Channel) in having very large adults, the ventral shield shape and the types of capillary notochaetae (three), while differing in shape and colour of the lateral lappets, branchiae length, the arrangement of segments, ventral shields, uncini and pygidial papillae. Large (> 30 cm long) and small (≈ 5 cm long) specimens of L. davidi sp. nov. show typically interspecific morphological differences while clustering in a single entity after species delimitation analyses of a cytochrome c oxidase I fragment. Therefore, we consider them to belong to a single species and discuss the taxonomic implications of size-dependent morphological differences. Within Loimia, we (1) suggest that large specimens may have been scarcely reported due to their rarity and collecting difficulty, while small specimens may have been reported either as ‘sp. ’ or as the ‘cosmopolitan’ Loimia medusa (Savigny, 1822), (2) evaluate the size-related morphological disparity in all described species using a hypervolume analysis, (3) identify possible similar size-dependency in previously described species, (4) summarise the morphological information of all known species of Loimia; and (5) discuss on the four species reported in Europe.