Miracle-dz/UniFAR-FTUs huggingface dataset:
Personalized identification of unusual user events in mobile cloud systems via a hybrid fusion design

We demonstrate the feasibility of constructing a mobile cloud system that efficiently, conveniently and accurately fuses multimodal smartphone sensor data to identify and log unusual personal events in mobile users' daily lives. Our myBlackBox system is designed to leverage a smartphone as a personalized blackbox-like recorder. In the system, we develop new location-based classifiers for audio and accelerometer that are personalized and noise-resistant. The system incorporates a hybrid architectural design that combines unsupervised classification of audio, accelerometer and location data with supervised joint fusion classification to achieve good accuracy, customization, convenience and scalability. We identify the best supervised learning algorithm for fusing together multi-modal mobile sensor data for unusual event identification and characterize its improvement in accuracy over location-based audio and activity classifiers. Finally, we show the feasibility of the myBlackbox concept by implementing and evaluating an end-to-end system that combines Android smartphones with a cloud server over a deployment consisting of fifteen users for over a one month period.
Upstream Approaches to Addressing Prescription Stimulant Misuse and Diversion: Exploring Perspectives of College Students Who Misuse and Divert

Background We interviewed college students who engage in prescription stimulant misuse and diversion to better understand perspectives on prevention and intervention strategies. Methods Trained student researchers at one southern California university completed 32 face-to-face interviews with students who had a history of misuse and/or diversion. Participants provided insights on programs, policies, and practices that have the potential to deter behavior. Data were analyzed inductively via thematic analysis. Results Students were often misinformed or unaware of existing programs, policies and practices. Additionally, some students felt their behaviors would not be detected, whereas other students felt the fear of being detected would lead them to change their behaviors. Harm reduction and treatment-based approaches to address misuse were also recommended. Conclusions Our findings emphasize the importance of better educating students about, and enforcing, existing policies. In addition, the need to better inform students of existing campus programs is warranted.
Identification of Zinc Efficiency-Associated Loci (ZEALs) and Candidate Genes for Zn Deficiency Tolerance of Two Recombination Inbred Line Populations in Maize

Zinc (Zn) deficiency is one of the most common micronutrient disorders in cereal plants, greatly impairing crop productivity and nutritional quality. Identifying the genes associated with Zn deficiency tolerance is the basis for understanding the genetic mechanism conferring tolerance. In this study, the K22×BY815 and DAN340×K22 recombination inbred line (RIL) populations, which were derived from Zn-inefficient and Zn-efficient inbred lines, were utilized to detect the quantitative trait loci (QTLs) associated with Zn deficiency tolerance and to further identify candidate genes within these loci. The BLUP (Best Linear Unbiased Prediction) values under Zn-deficient condition (-Zn) and the ratios of the BLUP values under Zn deficient condition to the BLUP values under Zn-sufficient condition (-Zn/CK) were used to perform linkage mapping. In QTL analysis, 21 QTLs and 33 QTLs controlling the Zn score, plant height, shoot and root dry weight, and root-to-shoot ratio were detected in the K22×BY815 population and the DAN340×K22 population, explaining 5.5–16.6% and 4.2–23.3% of phenotypic variation, respectively. In addition, seventeen candidate genes associated with the mechanisms underlying Zn deficiency tolerance were identified in QTL colocalizations or the single loci, including the genes involved in the uptake, transport, and redistribution of Zn (ZmIRT1, ZmHMAs, ZmNRAMP6, ZmVIT, ZmNAS3, ZmDMAS1, ZmTOM3), and the genes participating in the auxin and ethylene signal pathways (ZmAFBs, ZmIAA17, ZmETR, ZmEIN2, ZmEIN3, ZmCTR3, ZmEBF1). Our findings will broaden the understanding of the genetic structure of the tolerance to Zn deficiency in maize.
Grape-Seed-Derived Procyanidin Attenuates Chemotherapy-Induced Cognitive Impairment by Suppressing MMP-9 Activity and Related Blood–Brain-Barrier Damage

(1) Background: Chemotherapy-induced cognitive impairment (CICI) is often observed in cancer patients and impairs their life quality. Grape-seed-orientated procyanidin has been shown to have anti-inflammatory and neuroprotective effects, yet its effects in preventing CICI have not been investigated. (2) Method: Adult male mice received 2.3 mg/kg cisplatin or saline injections for three cycles consisting of five daily injections followed by 5 days of rest. Procyanidin or saline was administered 1 h prior to cisplatin treatment. Cognitive testing, gelatin zymography, and blood–brain-barrier (BBB) penetration tests were performed after treatment cessation. RAW264.7 cells were treated by stimulated supernatant of SHSY5Y cells. In addition, high-mobility group protein B1 (HMGB1) expression and MMP-9 activity were tested. (3) Results: Repeated cisplatin treatment increased BBB penetration, MMP-9 activity, impaired performance in contextual fear conditioning, and novel object recognition tasks. The knockout of MMP-9 rescues cognitive impairment and cisplatin-induced upregulation of HMGB1 in SHSY5Y cells. HMGB1/TLR4/IP3K/AKT signaling contributes to the increased MMP-9 activity in RAW264.7 cells. Procyanidin treatment attenuates MMP-9 activity, BBB damage, and CICI. (4) Conclusions: The results indicated that MMP-9 activation and BBB disruption is involved in CICI. Procyanidin may effectively alleviate the harmful effects of cisplatin.
Double-Lung Transplantation in a Patient with Pulmonary Type B Niemann-Pick Disease: A Valid Treatment Option

Niemann-Pick disease is a rare autosomal recessive disease characterized by an abnormal intracellular lipid accumulation. Type B is later in onset and a less severe form of the disease, so affected people may survive in adulthood. Storage of sphingomyelin in pulmonary macrophages can lead to interstitial lung disease. There are very few published cases of lung transplantation in patients with Niemann-Pick disease, all of them described in the last 2 years. We present here one case of a 57-year-old man successfully treated with a double-lung transplant.
Convective Drying Kinetics of Squash Epicarp of Cucurbita Maxima and Its Uses in Developing Gluten-Free Bread

This study was conducted to obtain semi-empirical mathematical models that represent the convective drying kinetics of squash epicarp at different temperatures (55, 65 and 75°C/10% RH/ drying speed 1ms -1 ). The best drying condition was selected to obtain flour, which was then characterized and used for the preparation of gluten-free bread. Subsequently, the effect of incorporating squash epicarp flour ( SEF ) into 4 levels (0-control, 15, 20 and 25g / 100 g of flour) on the sensory acceptance of the bread was evaluated. The results of this study are that the two-term model best describes the curve obtained at 55 °C, and the logarithmic model best describes the curves obtained at 65 °C and 75 °C. The temperature of 65 °C was selected as the best drying condition. Finally, the highest acceptance and purchase intention was obtained from the bread produced with 15 g SEF / 100 g of flour.
Photon Transfer Theory

A functional block diagram for a typical CCD/CMOS camera system is illustrated in Fig. 4.1. The system shown is described by the six transfer functions related to the semiconductor, pixel detector, and electronics that process the video signal. The input to the camera is expressed in units of the average number of incident photons per pixel (P), and the final output signal is given as the average DN encoded for each pixel. The output is related to the input gain relation S(DN) P =QEI I⋅ i A SN A SF A CDS A ADC , where the individual gain functions are given in Table 4.1.
AN UPDATE: ON NEEDLE FREE INJECTIONS

The aim of modern needle-free injection is to enhance the prescribing and adoption of important drugs that require self-injection, such as biologics. Invention of needle-free injection technologies is to achieve this by improving the patient experience and removing the barriers to self-injection, such as the fear of needles. According to Food and drug administration [FDA] A needle-less or needle free injection is a device used for the parenteral administration of a medicament is disclosed. They can take the form of power sprays, edible products, inhalers, and skin patches. Needle-free systems are designed to solve these problems making them safer, less expensive, and more convenient. It can be placed in the bore of a barrel with the barrel having the shape of a nosecone at one end. A plunger is inserted into the other end of the bore. The plunger forces the medicament through the skin and into the subcutaneous layer of the patient without the need for penetration of the skin by a needle. A needle-free syringe is placed into the filling adapter and the liquid is drawn into the needle-free syringe and is slightly over filled. The plunger is broken off and discarded. With the adapter, needle-free syringe, and vial still engaged the needle-free syringe is placed into the injector with a ¼ turn to the right, this returns excess medicine or vaccine back into the vial and positions the plunger to deliver a 0.5ml dose. Today, this is the most promising tool for delivering the medicament for suitable requirement.
Research on the Aging-Friendly Kitchen Based on Space Syntax Theory

As a result of aging populations globally, a growing number of older adults prefer to age in place; therefore, it is essential to study the spatial adaptability of the house. This study aimed to explore the relationship between the efficiency of daily activities and the spatial layout of home kitchens in the elderly population, and to assess the moderating role of cognitive function. Twenty-one elderly participants completed the experiment, including non-cognitively impaired (n = 12) and cognitively impaired groups (n = 9). Their home kitchen space was partitioned in plan and elevation based on space syntax theory. They were required to complete three tasks (i.e., an easy task, a medium task, and a difficult task) in their respective kitchens. The relationship between the efficiency of different tasks’ completion and the corresponding kitchen space attributes (integration, mean depth) was examined. The results showed a significant association between the home kitchen space layout of homebound older adults and their kitchen activity efficiency. In addition, a positive moderating effect of cognitive ability was found in the association between moderate and difficult tasks (p < 0.05), and its effect appeared to be stronger under challenging tasks (p < 0.01). The results of this study may help provide a basis for future design and optimization of aging-friendly residential spaces.
Estudio del desgaste de carriles en servicio y optimización de su mantenimiento

This work aims to study the natural wearing of the rails when it comes from the sliding effect of the wheels running on the rail surface. It also studies the influence of the applied high dynamic loads on the microstructure of the rail steel properties. The experimental part analyses real samples obtained from rails removed from the track and some other samples to which a forced wearing has been induced in the laboratory. All experimental data have been validated according to the Archard model of wearing, with satisfactory results. This investigation can be applied on the planning of the maintenance works for the rail, with focus on the optimization of preventive grinding intervals.
Recent research and development on power systems with a large number of distributed generating facilities

The paper describes the achievements and trend in research and development in Japan related to power system connections of a large number of distributed generation (DG). The major results from some of the R&D projects related to power system connections of PV or wind power generations are presented. In addition, current research activities for new technologies for distributing and managing power in power systems with a large number of DG are introduced.
The Meaning Construction of Jihad Muslim Youth Activists in Kabupaten Poso Provinsi Sulawesi Tengah

This study aims to determine The Meaning Construction of Jihad Muslim Youth Activists in Kabupaten Poso Provinsi Sulawesi Tengah, in guarding peace between Muslim groups and Christian groups. The purpose of this research is to find out the understanding and experience of Muslim youth activists, who until now the terrorist movement in the region continues to receive attention from the Indonesian National Police. The theories used to form the framework of thought in this research are Alfred Schutz's phenomenological theory, Luckmann and Berger's Social Construction Theory of Reality, and George Herbert Mead's Symbolic Interaction Theory. This study uses a qualitative method through a traditional phenomenological approach that focuses on life experiences and seeks meaning about reality based on the research subject's point of view. The results of the study show that there are Muslim youths who think that jihad is fighting to take up arms against the enemies of Islam. The experience of the Poso riots in 1998 – 2005, indicated that Muslims were not prepared to deal with rioters, resulting in massacres in several places. Three rioters were sentenced and executed, namely Fabianus Tibo, Dominggus da Silva, and Marinus Riwu. There are also Muslim youths who interpret jihad as an effort to build peace on the earth of Sintuwu Maroso , because of the motto of Kitorang Basudara . The riots occurred because of political interests that sacrificed ordinary people.
DEVELOPMENT OF THE JOINT POSITION SYSTEM FOR CONTROLLING THE EXOSKELETON BASED ON PNEUMATIC MUSCLES

There is an increasing demand for equipments to aid human locomotion, due to the great number of people presenting restrictions to perform their daily life task. The present work is part of Assistive Technology development program of the UFMG at the Laboratory of Bioengineering (LABBIO). There are many pathologies affecting the locomotor system and causing modifications on the execution of the gait. Nowadays, there are about 20 million survivors of poliomielitis in the world who face a new challenge: the Post-Polio Syndrome, a set of motor incapacities produced by the polio that appear many years after the patient had contact with the virus of polio. The volunteer patient presents neuromotor deficit on lower extremities causing deficit on locomotion due to a lesion caused by the polio virus. It was developed an assisted system of locomotion using a hip orthesis to fasten the artificial muscles to assist the flexion movement of the hip for the task of walking. This work presents the development of an electronic device capable of controlling the drive of the artificial muscle by means of data acquisitions of the articulate position captured by the potentiometers fastened on the orthesis attached to the patient. A pattern of activation and deactivation of the artificial muscle was set based on the angular behavior of the hip joint according to the normal cycle gait. Tests performed at the Laboratory of Prothesis and Orthesis with the patient, demonstrated improvement of the gait pattern of the patient with assisted movement of flexion of the left hip during walking.
Modulation of Mismatch Repair and the SOCS1/p53 Axis by microRNA-155 in the Colon of Patients with Primary Sclerosing Cholangitis

Deficient mismatch repair (MMR) proteins may lead to DNA damage and microsatellite instability. Primary sclerosing cholangitis (PSC) is a risk factor for colitis-associated colon cancer. MiR-155 is suggested to act as a key regulating node, linking inflammation and tumorigenesis. However, its involvement in the chronic colitis of PSC-UC patients has not been examined. We investigated the involvement of miR-155 in the dysregulation of MMR genes and colitis in PSC patients. Colon tissue biopsies were obtained from patients with PSC, PSC with concomitant ulcerative colitis (PSC-UC), uncomplicated UC, and healthy controls (n = 10 per group). In the ascending colon of PSC and PSC-UC patients, upregulated miR-155 promoted high microsatellite instability and induced signal transducer and activator of transcription 3 (STAT-3) expression via the inhibition of suppressors of cytokine signalling 1 (SOCS1). In contrast, the absence of miR-155 overexpression in the sigmoid colon of PSC-UC patients activated the Il-6/S1PR1 signalling pathway and imbalanced the IL17/FOXP3 ratio, which reinforces chronic colitis. Functional studies on human intestinal epithelial cells (HT-29 and NCM460D) confirmed the role of miR-155 over-expression in the inhibition of MMR genes and the modulation of p53. Moreover, those cells produced more TNFα upon a lipopolysaccharide challenge, which led to the suppression of miR-155. Additionally, exposure to bile acids induced upregulation of miR-155 in Caco-2 cell lines. Thus, under different conditions, miR-155 is involved in either neoplastic transformation in the ascending colon or chronic colitis in the sigmoid colon of patients with PSC. New insight into local modulation of microRNAs, that may alter the course of the disease, could be used for further research on potential therapeutic applications.
Genetic and Genomic Resources for Soybean Breeding Research

Soybean (Glycine max) is a legume species of significant economic and nutritional value. The yield of soybean continues to increase with the breeding of improved varieties, and this is likely to continue with the application of advanced genetic and genomic approaches for breeding. Genome technologies continue to advance rapidly, with an increasing number of high-quality genome assemblies becoming available. With accumulating data from marker arrays and whole-genome resequencing, studying variations between individuals and populations is becoming increasingly accessible. Furthermore, the recent development of soybean pangenomes has highlighted the significant structural variation between individuals, together with knowledge of what has been selected for or lost during domestication and breeding, information that can be applied for the breeding of improved cultivars. Because of this, resources such as genome assemblies, SNP datasets, pangenomes and associated databases are becoming increasingly important for research underlying soybean crop improvement.
Supplementary Materials: Construction and Experimental Validation of a Quantitative Kinetic Model of Nitric Oxide Stress in Enterohemorrhagic Escherichia coli O157:H7

Figure S1. Training of extracellular model parameters. 50 μM DPTA NONOate was delivered to cell-free media (MOPS minimal media with 10 mM glucose) at 50 and 0 μM O2, and [NO·] was measured (solid red lines; mean of 3 independent experiments, with light red shading representing the SEM). For the 0 μM O2 condition, the media pH was adjusted to 7.2 (from 7.4) with HCl, to mimic the slightly acidified conditions measured in the bioreactor culture for anaerobic assays with EHEC. Model parameters specific to the experimental apparatus and media conditions (kNO·-O2, kLaNO·, and kNONOate) were optimized on the [NO·] curve measured at 50 μM O2 (dashed black line using the best-fit parameter set, with gray shading representing the range of viable parameter sets with ER < 10). Since a decrease in pH increases the rate of NONOate dissociation, the kNONOate parameter was released and trained on [NO·] measured in the pH-adjusted media at 0 μM O2. The simulation result using the trained kNONOate parameter is shown (dashed black line, obtained using the best-fit parameter value, with gray shading representing viable parameter values with ER < 10). Figure S2. Training of parameters associated with the respiratory module. TUV hmp + /norV + in midexponential phase were delivered to the bioreactor to an OD600 of 0.05, and the O2 consumption was measured (solid purple line; mean of 3 independent experiments with light purple shading representing the SEM). Model parameters associated with the aerobic respiratory module (NADH dehydrogenases and cytochrome ubiquinol oxidases) were trained on the measured [O2]. The simulated [O2] generated by the trained model is shown (dashed black line was obtained using the best-fit parameter set, with gray shading representing the range of viable parameter sets with ER < 10).
Aesthetic Crown Lengthening Using Chu Proportion Gauges: A Case Report

Background: A harmonious smile is considered a symbol of beauty in modern society. Generally, a smileis considered pleasant when it normally exposes all of the maxillary teeth, as well as around 1 mmof facial gingiva. The gingival exposure of up to 2-3 mm is normally acceptable. The rehabilitation performed for the abnormalities in symmetry and contour of the gingiva in this region can be challenging. Crown-lengthening surgery is used in combination with perio-aesthetic procedures to repair gingival asymmetries and realign the dentogingival complex. The Chu’s aesthetic gauges were designed to diagnose and treat aesthetic tooth discrepancies and abnormalities in a predictable manner. Objective: To attain optimal crown lengthening using Chu’s aesthetic gauges. Case Report: A 21-year-old female patient presented to the Department of Periodontology, with a request for “better-looking teeth”. Extraoral examination revealed no significant findings. No mobility and adequate levels of keratinized attached gingiva on intraoral examination. The case was diagnosed as a gummy smile, that could be repaired with crown lengthening. During the surgical crown-lengthening, Chu’s aesthetic gauges were used to measure the midfacial length of the biologic crown at the same time. These gauges are unique technique that is innovative and a novel method to get adequate crown proportions. Results: Evaluation after two weeks after the surgery showed a better-looking smile line and no erythema. Conclusion: A successful crown-lengthening procedure was performed using Chu’s aesthetic measurement, including optimal dimension of clinical crowns and symmetrical gingival contour. Keywords: crown lengthening, aesthetic procedure, Chu’s aesthetic gauges, case report
Is Conventional Management of Hyperpigmentation Still the Best Choice? -- A Case Report

Background: A normal gingiva is generally “salmon” pink in color. Varying degrees of brownish pigmentation in gingiva may be seen in Blacks (seldom also in Caucasians). Those who exhibit gingival hyperpigmentation face aesthetic problems. Objective: To describe the treatment of gingival hyperpigmentation in a 29-yearold male attending the Department of Periodontics Clinic, Universitas Padjadjaran, exhibiting excessive staining on the gums of the right to left canine region of the upper and lower jaw. Case Report: This gingival hyperpigmentation case was managed through a conventional method of using scalpel. Results: Gingiva that had excessive staining in this case was eliminated and exhibited good aesthetic. Conclusion: The conventional management of gingival hyperpigmentation is still the best choice to solve an aesthetic problem with a simpler and safer technique, and at more affordable costs. Keywords: gingival hyperpigmentation, gum excessive staining, conventional gingival surgery