Miracle-dz/UniFAR-FTUs huggingface dataset:
Open Access Rheumatology: Research and Reviews Dovepress Potential Serum and Urine Biomarkers in Patients with Lupus Nephritis and the Unsolved Problems

you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms Abstract: Lupus nephritis (LN) is one of the most frequent and serious complications in the patients with systemic lupus erythematosus. Autoimmune-mediated inflammation in both renal glomerular and tubulointerstitial tissues is the major pathological finding of LN. In clinical practice, the elevated anti-dsDNA antibody titer concomitant with reduced complement C3 and C4 levels has become the predictive and disease-activity surrogate biomarkers in LN. However, more and more evidences suggest that autoantibodies other than anti-dsDNA antibodies, such as anti-nucleosome, anti-C1q, anti-C3b, anti-cardiolipin, anti-endothelial cell, anti-ribonuclear proteins, and anti-glomerular matrix (anti-actinin) antibodies, may also involve in LN. Researchers have demonstrated that the circulating preformed and in situ-formed immune complexes as well as the direct cytotoxic effects by those cross-reactive autoantibodies mediated kidney damage. On the other hand, many efforts had been made to find useful urine biomarkers for LN activity via measurement of immune-related mediators, surface-enhanced laser desorption/ ionization time-of-flight mass spectrometry proteomic signature, and assessment of mRNA and exosomal-derived microRNA from urine sediment cell. Our group had also devoted to this field with some novel findings. In this review, we briefly discuss the possible mechanisms of LN and try to figure out the potential serum and urine biomarkers in LN. Finally, some of the unsolved problems in this field are discussed.
Diagnostics of the black hole candidate SS433 with the RXTE

We present our analysis of the extensive monitoring of SS433 by the RXTE observatory collected over the period 1996-2005. The difference between energy spectra taken at different precessional and orbital phases shows the presence of strong photoabsorption (N_H>10^{23}cm^{-2}) near the optical star, probably due to its powerful, dense wind. Therefore the size of the secondary deduced from analysis of X-ray orbital eclipses might be significantly larger than its Roche lobe size, which must be taken into account when evaluating the mass ratio from analysis of X-ray eclipses. Assuming that a precessing accretion disk is geometrically thick, we recover the temperature profile in the X-ray emitting jet that best fits the observed precessional variations in the X-ray emission temperature. The hottest visible part of the X-ray jet is located at a distance of l_0/a~0.06-0.09, or ~2-3*10^{11}cm from the central compact object, and has a temperature of about T_{max}~30 keV. We discovered appreciable orbital X-ray eclipses at the ``crossover'' precessional phases (jets are in the plane of the sky, disk is edge-on), which under model assumptions put a lower limit on the size of the optical component R/a>0.5 and an upper limit on a mass ratio of binary companions q=M_x/M_{opt}<0.3-0.35, if the X-ray opaque size of the star is not larger than 1. 2R_{Roche, secondary}.
SELF-FULLING PROPHECIES AND THE BUSINESS CYCLE

At that time, the idea of a sunspot equilibrium was much discussed at the University of Pennsylvania, but was regarded by most macroeconomists as an esoteric branch of general equilibrium theory of little obvious importance for macroeconomics. The examples of sunspot equilibria that were known at the time were highly stylized, and, for example, involved only a finite number of random states. The contribution of our paper was to exploit the indeterminacy of equilibrium, a phenomenon that is common in overlapping generations models, to construct sunspot equilibria in a version of the model introduced by Robert Lucas in his 1972 JET paper. The technique that we describe for constructing sunspot equilibria has proven to be widely applicable to intertemporal general equilibrium models with indeterminacy, and has since been exploited in a variety of different environments, including many models with infinite-lived agents, some of which are quite similar to the kind of stochastic growth model used in real business cycle theory. The equilibria constructed using this method are described by stationary probability distributions that fulfill all of the desiderata of rational choice in a stationary environment, but in which the beliefs of agents are no longer uniquely determined by economic " fundamentals ". In the context of our example, we show that there is a continuum of alternative stationary rational expectations equilibria, and that some of these equilibria have " Keynesian " features, in the sense that quantities rather than prices respond to monetary shocks. We do not take up the question of the quantitative similarity of the predicted stationary fluctuations to the properties of actual aggregate data, although our methods would allow such questions to be addressed, as they have been more recently, in the context of more sophisticated models. 3 Our purpose in publishing the article in MD is to provide a convenient English-language source. Although the paper is widely cited and a Spanish translation was published in 1987, it has never before been published in English. 4 Introduction In this paper we demonstrate the existence of many stationary rational expectations equilibria in a variant of the model considered by Lucas (1972). Wallace (1984) have observed that linear rational expectations models may possess a continuum of stationary equilibria, but the hope has been expressed that the multiplicity is possible only because these models are not derived rigorously from the optimizing behavior of agents (e.g., However, a growing literature shows …
Eecient Temporal Join Processing Using Indices

We examine the problem of processing temporal joins in the presence of indexing schemes. Previous work on temporal joins has concentrated on non-indexed relations which were fully scanned. Given the large data volumes created by the ever increasing time dimension, sequential scanning is prohibitive. This is especially true when the temporal join involves only parts of the joining relations (e.g., a given time interval instead of the whole timeline). Utilizing an index becomes then beneecial as it directs the join to the data of interest. We consider temporal join algorithms for three representative indexing schemes, namely a B+-tree, an R*-tree and a temporal index, the Multiversion B+-tree (MVBT). Both the B+-tree and R*-tree result in simple but not eecient join algorithms because neither index achieves good temporal data clustering. Better clustering is maintained by the MVBT through record copying. Nevertheless, copies can greatly aaect the correctness and eeectiveness of the join algorithms. We identify these problems and propose eecient solutions and optimizations. An extensive comparison of all index based temporal joins, using a variety of datasets and query characteristics shows that the MVBT based join algorithms are consistently faster. In particular the link-based algorithm has the most robust behavior. In our experiments it showed a tenfold improvement over the R*-tree joins while it was between six and thirty times faster than the B+-tree joins.
Implicit Self-attitudes Predict Spontaneous Affect in Daily Life Implicit Self-attitudes Implicit Self-attitudes and Affect

In 2 studies, the authors examined the degree to which implicit self-attitudes predicted people's spontaneous affective experiences in daily life. Across both studies, implicit attitudes toward the self (as measured by Implicit Association Tests) strongly predicted negative feeling states (as measured by computerized experience-sampling procedures), suggesting that implicit self-attitudes may be linked to changes in undifferentiated negative affect. Explicit attitudes toward the self generally did not account for these relations. Findings extend understanding of the factors that contribute to experienced affect and are the first to empirically link implicit self-attitudes with phenomenological affective experience in real-life settings over time. The experience of emotion is fundamental to understanding the human condition and central to a range of topics in psychological science. Feelings are a window into the psychological impact of events in our lives and serve as important markers of mental health. Given their importance, it is crucial to understand the factors that account for why people differ in their emotional lives. Why does one person feel anxious and threatened, whereas another feels relaxed and happy? Because many of our mental processes, it stands to reason that automatic processing tendencies play an important role in the quality or content of what we feel. This report examined how one such factor—implicit attitudes about the self—predicts momentary experiences of affect, as measured in everyday life. People evaluate and form attitudes about most objects in the world (Fazio, 2001), including about ourselves. Although it was once assumed that all self-attitudes were explicit (i.e., directly measurable by means of self-report), it is now known that we possess attitudes about ourselves that are implicit, measurable indirectly using procedures that bypass self-These indirectly measured attitudes, commonly referred to as implicit self-attitudes or implicit self-esteem (Farnham, Greenwald, & Banaji, 1999), are thought to reflect traces of early experiential learning whereby we automatically learn to associate our self-concept with positivity or nega-Although there is debate as to whether or not people are consciously aware of their implicit self-attitudes (Fazio & Olson, 2003; Greenwald & Banaji, 1995; Wilson et al., 2000), there is evidence to suggest that people cannot introspect on these attitudes. What people directly report about themselves and what is revealed using implicit measures often do not correlate, even when taking into account people's motivations to conceal negativity in their self-reports (i.e., because of self-presentational concerns; Egloff & Schmukle, 2003). Implicit self-attitudes, like other implicit attitudes, are akin …
Hengdian as a Model of Collectivized Development of Movie-and-TV Industry in China:A Case Study from the Perspective of the Shared-resource Theory

This paper,based on the analytical framework of the industrial-cluster theory on shared resources,is a comprehensive study of Hengdian as a model of China's collectivized development of the movie-and-TV industry,particularly of its success in the development of the movie-and-TV-related tourism.It then explores the theoretical issues in regard to the development and evolution of China's movie-and-TV industrial clusters.The study shows that the shaping and growth of the movie-and-TV industrial cluster in Hengdian is attributed to its shared resources,which,being heterogeneous and locally rooted,make the accumulative expansion possible,thereby turning themselves into higher-level heterogeneous resources with more strategic value;that its motivation of development comes from its continuous learning and innovation;that its model of development is more and more distinctive,characterized by the combination of movie production and movie-related tourism while making itself a national and even international center of movie making;and that its model of development,experience and typical problems it is faced with,are of important significance to the collectivized development of the movie industry in China.
Surface-attached amphipathic peptides reduce hemorrhage in vivo

Background: The leading causes of death for trauma patients in civilian and combat settings are traumatic brain injury and uncontrolled hemorrhage, respectively. This study examines the hemostatic activity of an ideal amphipathic peptide (IAP) attached to a biocompatible surface. Methods: Procoagulant properties of IAP attached to a surface were first tested, in vitro, using factor Xa and thrombin generation assays and thromboelastography. Rabbits and swine were used for in vivo studies. Injuries were performed using scalpel blade 11, and free bleeding was allowed for five seconds. While bleeding, IAP coupled to a hydrogel or QuikClot were applied to the wound and the time was recorded until bleeding stopped. Results: Results show that when IAP is attached to a surface, both factor IXa and factor Xa activities are promoted. Thromboelastography shows that surface-attached IAP results in earlier onset and stronger clot formation. In rabbits, the incorporation of IAP onto a biocompatible hydrogel reduces bleeding times by 40% (p < 0.03). In pigs, bleeding times are reduced 30% to 50% (p < 0.02) by surface-coupled IAP. Finally, using a rabbit liver laceration model, the properties of surface-coupled IAP are less damaging when compared with QuikClot, a currently used material in external hemorrhagic injuries. Conclusions: This study provides a relevant proof of concept for the development of IAP coupled to a biocompatible surface as a hemostatic agent, that is potentially safer than the commercially available QuikClot.
Counting Roots of Polynomials Over Prime Power Rings

Suppose $p$ is a prime, $t$ is a positive integer, and $f\! \in\! \mathbb{Z}[x]$ is a univariate polynomial of degree $d$ with coefficients of absolute value $<\! p^t$. We show that for any fixed $t$, we can compute the number of roots in $\mathbb{Z}/(p^t)$ of $f$ in deterministic time $(d+\log p)^{O(1)}$. This fixed parameter tractability appears to be new for $t\! \geq\! 3$. A consequence for arithmetic geometry is that we can efficiently compute Igusa zeta functions $Z$, for univariate polynomials, assuming the degree of $Z$ is fixed.
Nonhydrolytic synthesis of branched alkoxysiloxane oligomers Si[OSiH(OR)2]4 (R=Me, Et).

Silicon alkoxides are ideal starting materials for the preparation of silica-based materials. The development of synthetic methods toward various alkoxysiloxane oligomers with finely controlled structures and reactivities is important for the synthesis of materials with defined compositions, structures, morphologies, and functionalities. 3] However, examples of the rational synthesis of alkoxysiloxane oligomers are limited. The controlled formation of Si O Si bonds is a key step in the synthesis of alkoxysiloxane oligomers. A conventional synthesis involves hydrolysis of silicon alkoxides or chlorosilanes to form silanol groups and a subsequent condensation reaction. Although the reaction of chloroalkoxysilanes with organosilanols have been reported, 4] the number of molecules synthesized by using this reaction are quite limited because the reaction is restricted to the cases where the resulting organosilanols are stable. The formation of silanol groups during the reaction causes unwanted side reactions, such as self-condensation of silanols and subsequent hydrolysis of terminal alkoxy groups. Therefore, the synthesis of siloxane oligomers that contain alkoxy groups with defined structures is a challenge in circumventing the problem of side reactions. The formation of siloxane bonds without using silanols has attracted much interest. Alkoxysiloxanes can be synthesized by the reaction between chlorosilane and sodium alkoxysilanolates. On the other hand, the use of alkoxysilanes as a precursor with a Lewis acid catalyst is the most promising pathway. The formation of siloxane bonds proceeds with the generation of RX (X = Cl, Br, I, AcO, or H). No competing reagents, such as compounds containing silanol groups, H2O, or HCl, are involved in the overall process. Oligosiloxanes with defined structures that contain more than one alkoxy group are difficult to synthesize, 15] as side reactions, such as ligand exchange, compete with the formation of siloxane bonds. 9, 13,14] Herein we report the nonhydrolytic synthesis, with suppressed side reactions, of branched alkoxysiloxanes Si[OSiH(OR)2]4 (R = Me (1), Et (2)), which possess both reactive SiOR and SiH groups. The reaction proceeds by direct alkoxysilylation of tetraalkoxysilanes with ClSiH(OR)2 in the presence of BiCl3 (Scheme 1). BiCl3, a weak Lewis acid,
OPTIMIZATION OF RESOURCES WITH INTERNET OF THINGS(IOT) IN HEALTHCARE, MINING, TRANSPORTAION AND LOGISTICS INDUSTRY

Internet of Things is a future technology which connects every electronic device to each other over Internet to make a smart system of systems. Internet of things connect person-person, person-device, also device-device. This technology has wide area applications in industry, business, public administration and e-Governance. Every industry and business firm tries to develop their own IoT application to improve production of goods, services, customer satisfaction, safety of their employees and their storage areas. This paper discusses role of IoT in optimization of resources in health-care industry, mining industry, transportation and logistics industry, further it presents sense and control of hazards in mining by connecting all equipment and sensors over IoT system, in Automotive Industry, it is proposed that IoT system may collect data from user Automobile to improve the design of vehicles and can also be used for research purposes to improve efficiency, it can identify defective parts of the vehicle which needs to replaced, in Transportation and Logistic Industry, it proposed to use the GPS and RFID tag to track consignment and transport vehicle. Keywords—IoT; Medication; RFID; WMS. -------------------------------------------------------------------***-------------------------------------------------------------------t
Illiquidity and Indebtedness - Optimal Capital Structure Under Realistic Default Triggers in a Double Barrier Option Framework

Existing dynamic capital structure models are based on single triggers determining bankruptcy, mainly over-indebtedness or illiquidity. The latter one tends to underestimate optimal capital structures by ignoring capital providers' flexibility to inject fresh money. The former one leans towards overestimation as it neglects agency conflicts between equity investors and debt holders while implying infinitely "deep pockets" of equity investors. This article incorporates both constraints, over-indebtedness and illiquidity, examining corporate debt value and optimal capital structure in a double barrier world with knock-in and knock-out options. We are first to derive closed-form solutions for all value components of a levered firm and for the optimal capital structure in such a setting. By testing our model for firms publicly listed in the US, we gain evidence that incorporating both triggers allows for capital structure estimations that are in accordance with empirical findings.
Méthodes d'analyse de la variabilité et de conception robuste des circuits analogiques dans les technologies CMOS avancées

Avec la miniaturisation toujours plus poussee des technologies CMOS, il devient de plus en plus difficile de maitriser les variations des parametres technologiques lors de la fabrication des circuits integres. A cause de ces variations, les performances des circuits peuvent varier de facon considerable. Par consequent, des methodes d'analyse de la variabilite et de conception robuste sont plus que jamais necessaires pour garantir un rendement de fabrication des circuits eleve.Les techniques classiques d'analyse de la variabilite se revelent soit pessimistes conduisant alors a un surdimensionnement (analyse " pire-cas "), soit tres couteuses en temps de calcul (analyse Monte Carlo). Quant aux methodes de conception automatisee robuste, elles sont generalement basees sur des algorithmes d'optimisation locaux qui ameliorent la robustesse des circuits localement, mais risquent de ne pas converger vers le dimensionnement globalement robuste. Dans ce travail de these, une nouvelle methode d'analyse de la variabilite ainsi qu'une nouvelleapproche pour concevoir des circuits analogiques robustes ont ete developpees. La methode d'analyse de la variabilite consiste a approximer les performances des circuits par des modeles polynomiaux a partir des plans d'experiences, puis a estimer les variations extremes grâce au developpement limite de Cornish-Fisher. Cette methode s'avere aussi precise que l'analyse de Monte Carlo, mais presente un cout calculatoire bien plus faible. Enfin, l'approche de conception robuste met en oeuvre la methode precedente d'analyse de la variabilite dans un algorithme d'optimisation par intervallesafin d'assurer un dimensionnement globalement robuste.
Robustness study of free-text speaker identification and verification

Usable free-text speaker identification and voice verification systems must exhibit robustness under varying operational conditions. The authors study the degree of robustness provided by various signal processing techniques by experimenting on a widely used long distance telephone database. This database consists of data recorded at two different sites, with data from one site much poorer in quality than that from the other. Further, the recording equipment had been inadvertently changed for the later half of the sessions, resulting in a significantly changed environment. The combination of techniques that provide consistent and significant improvements is identified. The present results surpass other published results on the same task. Specifically, in the task of identifying 16 speakers with training data from the recording prior to equipment change and testing on data from a set after the change (the most challenging condition), a correct identification rate of 87.5% with an average rank of 1.12 was obtained. <<ETX>>
Dosage and Duration Effects of Korean Red Ginseng Intake on Frequency of Gross Deletions in the nef Gene

In the present study, we investigated whether a gross deletion in the nef gene (g? nef) is induced by Korean red ginseng (KRG) intake. Ten patients were treated with KRG powder for 3 years in the absence of antiretroviral drug therapy. On average, 3,555 ± 1,042 g KRG was administered per person over 36.1±2.4 months. There was a mild decrease in CD4 T cell count (75 ± 110/mL) over the 36.1±2.4 months (p = 0.059). We obtained 355 nef amplicons using 71 peripheral blood mononuclear cell samples over a 3? year period. All ten patients exhibited g? nef (range, 3.2 to 45.9%). At baseline, 3 of 78 amplicons (3.8%) exhibited g? nef, whereas 18.8% (52/277) revealed g? nef during KRG? intake (p < 0.001). The proportion of g? nef was significantly correlated with monthly dose of KRG (r = 0.89, p < 0.001). The median time for first detection of g? nef was 13 months. In conclusion, our data show that g? nef is inducible by KRG intake and its proportion is dependent on the duration of KRG intake and dose of KRG.