Miracle-dz/UniFAR-FTUs huggingface dataset:
Robust approximate modelling of stable linear systems

Robust approximation and worst-case approximate modelling of stable shift-invariant systems from corrupted transfer function estimates are studied in the H ∞ sense. Connections between the problem formulations of the present work and certain problems of worst-case system identification, notably the Helmicki-Jacobson-Nett problem formulation for identification in H ∞, are established. Issues of model set selection are addressed using the n-width concept: a concrete result establishes a priori knowledge for which a certain rational model set is optimal in then-width sense. A notion of robust convergence is defined so that any untuned approximation method satisfying it has a generic well-posedness property for systems in the disk algebra. The existence of robustly convergent approximation methods based on any complete model set in the disk algebra is shown in a constructive way. A framework is given in which approximate models can be obtained as stable perturbations of the true system: these can be combined .
MFPNet: using multi-type features parallelism in deep layers to improve segmentation performance for pavement cracks

Aiming at the difficulty of accurately segmenting pavement cracks in traditional detection methods, this paper proposes a lightweight real-time detection model named MFPNet with an end-to-end encoding and decoding structure. Firstly, in the encoding stage, based on the different extraction characteristics of the involution-G and convolution operators for cracks, the designed multi-type features parallel (MFP) module is used in the deep network to enhance the abstract semantic information with reducing information loss. Then, the simplified long connection structure is adopted in the decoding stage to maintain the detection speed without reducing the detection accuracy. Additionally, ablation experiments demonstrate the effectiveness of the designed module. What’s more, compared with other deep learning-based algorithms, the model proposed in this paper has excellent performance, and its MIOU, Recall, and F1 Score reach 0.7705, 0.8023, and 0.8485, respectively. In practice, MFPNet can be implemented in images with a high resolution of 2048×1024 in real time.
Predicting Tumor Mutation Burden and EGFR Mutation Using Clinical and Radiomic Features in Patients with Malignant Pulmonary Nodules

Pulmonary nodules (PNs) shown as persistent or growing ground-glass opacities (GGOs) are usually lung adenocarcinomas or their preinvasive lesions. Tumor mutation burden (TMB) and somatic mutations are important determinants for the choice of strategy in patients with lung cancer during therapy. A total of 93 post-operative patients with 108 malignant PNs were enrolled for analysis (75 cases in the training cohort and 33 cases in the validation cohort). Radiomics features were extracted from preoperative non-contrast computed tomography (CT) images of the entire tumor. Using commercial next generation sequencing, we detected TMB status and somatic mutations of all FFPE samples. Here, 870 quantitative radiomics features were extracted from the segmentations of PNs, and pathological and clinical characteristics were collected from medical records. The LASSO (least absolute shrinkage and selection operator) regression and stepwise logistic regressions were performed to establish the predictive model. For the epidermal growth factor receptor (EGFR) mutation, the AUCs of the clinical model and the integrative model validated by the validation set were 0.6726 (0.4755–0.8697) and 0.7421 (0.5698–0.9144). For the TMB status, the ROCs showed that AUCs of the clinical model and the integrative model validated by the validation set were 0.7808 (0.6231–0.9384) and 0.8462 (0.7132–0.9791). The quantitative radiomics signatures showed potential value in predicting the EGFR mutant and TMB status in GGOs. Moreover, the integrative model provided sufficient information for the selection of therapy and deserves further analysis.
Excitation Mechanism of Mixed Rossby–Gravity Waves in the Equatorial Atmosphere: Role of the Nonlinear Interactions among Equatorial Waves

Abstract One possible explanation for the relatively high signal of the mixed Rossby–gravity waves observed in the tropical atmosphere is explored in this paper. This explanation is based on the nonlinear interactions among equatorial waves, and is made by adopting the nonlinear shallow water equations on the equatorial β plane. These equations are solved by a spectral method that uses the eigensolutions of the linear problem as the expansion basis. Numerical simulations are performed with a specified stationary mass source representative of the tropospheric heating associated with the typical convective activity over the Amazon Basin during the austral summer period. The numerical results show that the mixed Rossby–gravity waves are excited by a nonlinear mechanism in which the slow modes excited by the thermal forcing generate a quasigeostrophic basic state that supplies energy especially to the mixed Rossby–gravity waves with zonal wavenumbers 4 and 5, which have periods of the order of 4 days. The pha.
Solar wind modulation of galactic cosmic rays

We have analyzed the annual mean hourly data for the solar wind speed (V), the interplanetary magnetic field (IMF) intensity (B), and the neutron monitor (NM) rates for 1964–1998, covering three sunspot number (SSN) cycles (20, 21, 22). The analysis brings out some of the steady state characteristics of the long‐term changes in the observed galactic cosmic ray (GCR) modulation and the ‘mini’ cycle. We find that BV time series reproduces the observed variations of a variety of phenomena, including the 11‐yr and the 27‐day GCR modulations. We reaffirm that convective removal of GCR by the solar wind accounts for a major part of the observed modulations in the inner heliosphere.
Relationships between technical and physical match performance in elite soccer

Introduction: The purpose of this study was to investigate the potential associations between physical and technical match performance and to compare these activities in relation to the match outcome. Materials and methods: The research was based on an analysis of 622 matches of the Polish Ekstraklasa during three consecutive seasons. Such variables as total distance, distance covered in different speed zones, effective playing time, ball possession, number of passes and passing accuracy were taken into account. Results: Effective playing time (Et) was significantly and fairly correlated with total distance (r = 0.39, p < 0.001), ball possession (r = 0.50, p < 0.001), number of passes (r = 0.40, p < 0.001), number of accurate passes (r = 0.43, p < 0.001) and passing accuracy (r = 0.42, p < 0.001). The comparison of the match performance according to the game outcome indicated that the total and sprinting distance covered by winning teams were significantly (p < 0.01) longer than in losing teams (113.3 vs 112.7 km). In turn, the defeated teams had signifi-cantly greater ball possession (28.3 vs 26.4 mins) and performed a larger number of passes (470 vs 428) than the winning teams. Conclusions: Et is one of the factors influencing the physical and technical match performance. Coaches should be aware that their team will have to cover a longer distance when playing against teams that prefer to keep the ball.
Near-infrared spectra and classification diagnostics of Seyfert galaxies

Observational results of a spectroscopic survey of Seyfert galaxies in the near-infrared are presented, and the potential for using emission-line ratios in this spectral region as a classification diagnostic tools is examined. Near-infrared CCD spectra, which cover the range λλ7000-10000 at nominal resolution FWHM ∼ 12 A, of 15 additional Seyferts and two starburst galaxies were obtained with the Lick Observatory 3 m Shane telescope
A functional differential equation arising in modelling of cell growth

Abstract A functional differential equation for the steady size distribution of a population is derived from the usual partial differential equation governing the size distribution, in the particular case where birth occurs by one individual of size x dividing into α new individuals of size x/α. This leads, in the case of constant growth and birth rate functions, to the functional differential equation y′(x) = −ay(x) + aαy(αx) together with the integral condition We first look at a number of properties that any solution of this equation and boundary condition must have, and then proceed to find the unique solution by the method of Laplace transforms. Results from number theory on the infinite product found in the solution are presented, and it is shown that y(x) tends to a normal distribution as α → 1+.
Detection of Escherichia coli in Food Samples Using Culture and Polymerase Chain Reaction Methods

Methods for the rapid detection of Escherichia coli and its related toxins are key to minimizing the risk of exposure to foodborne pathogens. The present study aimed to detect E. coli in food specimens using culture and polymerase chain reaction (PCR) techniques. One hundred and fifty samples from different types of food, comprising beef (n=60), chicken (n=72), and fish (n=18), were analyzed for the identification of E. coli by conventional and PCR methods. The results showed that out of 150 food samples, 44 (29.3%) were positive by culture, and 50 (33.3%) were positive by PCR. Significant differences were detected between sample types with culture (p-value < 0.005). When culture was considered the gold standard, the sensitivity of PCR was 100%, while the specificity was 94.34%. The six-hour pre-enrichment and PCR analysis are reliable in fast detection of E. coli in food samples. Hence, the identification of food pathogens using molecular-based methods would become more useful in routine diagnostic laboratories
Use of helium double ionization for autocorrelation of an xuv pulse

We investigate a simple scheme for autocorrelation measurement of an xuv pulse. It is based on double ionization of He. We have found that, in a certain photon energy range, the detection of doubly charged positive ions instead of energy-resolved photoelectrons is sufficient for autocorrelation, which greatly simplifies the detection system for practical use.
Migraine and temporomandibular disorder triggered by stress-induced bruxism: a case report

Migraine is the most common primary headache that associated with temporomandibular disorders (TMD) that is known as number of clinical problemsinvolving the masticatory muscles, temporomandibular joint and associated structures. Bruxism may be considered as an important factor of initiation of TMDand stress might be the contributory factor. This article is aimed to discuss the management of migraine and TMD patient with stress-induced bruxism as aprecipitating factor. A 42-year-old male patient visited RSKGM FKGUI due to throbbing pain, headache and discomfort around ear and face. Patient was diag-nosed myalgia based on DC/TMD with no articular joint disorder and migraine according to orofacial pain classification axis-1 following with anxiety disorder and stress. A stabilization appliance was designed followed with patient education, physical therapy and stress management. It was concluded that treatment combination of stabilization appliance, stress management and significantly improve the patient’s condition with lessen migraine attack and TMD symptoms.
Role of Hepatocyte Transporters in Drug-Induced Liver Injury (DILI)—In Vitro Testing

Bile acids and bile salts (BA/BS) are substrates of both influx and efflux transporters on hepatocytes. Canalicular efflux transporters, such as BSEP and MRP2, are crucial for the removal of BA/BS to the bile. Basolateral influx transporters, such as NTCP, OATP1B1/1B3, and OSTα/β, cooperate with canalicular transporters in the transcellular vectorial flux of BA/BS from the sinusoids to the bile. The blockage of canalicular transporters not only impairs the bile flow but also causes the intracellular accumulation of BA/BS in hepatocytes that contributes to, or even triggers, liver injury. In the case of BA/BS overload, the efflux of these toxic substances back to the blood via MRP3, MRP4, and OST α/β is considered a relief function. FXR, a key regulator of defense against BA/BS toxicity suppresses de novo bile acid synthesis and bile acid uptake, and promotes bile acid removal via increased efflux. In drug development, the early testing of the inhibition of these transporters, BSEP in particular, is important to flag compounds that could potentially inflict drug-induced liver injury (DILI). In vitro test systems for efflux transporters employ membrane vesicles, whereas those for influx transporters employ whole cells. Additional in vitro pharmaceutical testing panels usually include cellular toxicity tests using hepatocytes, as well as assessments of the mitochondrial toxicity and accumulation of reactive oxygen species (ROS). Primary hepatocytes are the cells of choice for toxicity testing, with HepaRG cells emerging as an alternative. Inhibition of the FXR function is also included in some testing panels. The molecular weight and hydrophobicity of the drug, as well as the steady-state total plasma levels, may positively correlate with the DILI potential. Depending on the phase of drug development, the physicochemical properties, dosing, and cut-off values of BSEP IC50 ≤ 25–50 µM or total Css,plasma/BSEP IC50 ≥ 0.1 may be an indication for further testing to minimize the risk of DILI liability.
On Drinfeld Modular Curves with Many Rational Points over Finite Fields

It is known that Drinfeld modular curves can be used to construct asymptotically optimal towers of curves over finite fields. Using reductions of the Drinfeld modular curves X"0(n), we try to find individual curves over finite fields with many rational points. The main idea is to divide by an Atkin-Lehner involution which has many fixed points in order to obtain a quotient with a better ratio #{rational points}/genus. In a few cases we can improve the known records of rational points.
The effects of Ortho Silicon (Optysil) and Ascophyllum nodosum Based Sea-weed Extract (KelpGreen) Applications on the Quality of Table Grape cvs. Gök Üzüm and Müşküle

Table grapes are one of the most consumed non-climacteric fruits globally, and practices for their quality are socioeconomically important. In this study, the effects of the combined and separate applications of two plant activators Ortho Silicon (Si, Optysil, 0.5 mL L-1) and Ascophyllum nodosum-based seaweed extract (ANE, KelpGreen 2.5 ml L-1) were tested by two applications after fruit set 15 days intervals to table grapes cvs. Gök Üzüm and Müşküle in a producer vineyard at Hadim town of Konya province in middle Anatolia37°2'15"N 32°34'53" E, 1060 m above sea level. The effects of the applications on ripening, cluster and berry characteristics and post harvest shelf life during 10 days of storage at room conditions were analyzed. Both plant activators provided an increase in cluster size and an improvement in ripening. Si+ANE was more effective on the maturation and quality retention during the post-harvest shelf-life period. All applications provided reduction in weight loss (WL), decay rate and berry dullness, and it reduced berry separation force due to the drying of the peduncle and decreased the maturity index (MI) increase in the post harvest period. Thus, it contributed to the formation and retention of fruit quality. According to the data obtained from this study, improvements in the sustainable preservation of table grape quality can be achieved by applying Ortho Silicon and A. nodosum based seaweed extract separately and together between after fruit set and before veraison.
Cross-Linked Sulfonated Poly(arylene ether sulfone) Membrane Using Polymeric Cross-Linkers for Polymer Electrolyte Membrane Fuel Cell Applications

Cross-linked membranes for polymer electrolyte membrane fuel cell application are prepared using highly sulfonated poly(arylene ether sulfone) (SPAES) and polymeric cross-linkers having different hydrophilicities by facile in-situ casting and heating processes. From the advantage of the cross-linked structures made with the use of polymeric cross-linkers, a stable membrane can be obtained even though the polymer matrix with a very high degree of sulfonation was used. In particular, hydrophilic cross-linker is found to be effective in improving physicochemical properties of the cross-linked membranes and at the same time showing reasonable proton conductivity. Accordingly, membrane electrode assembly made from the cross-linked membrane prepared by using hydrophilic polymeric cross-linker exhibits outstanding cell performance under high temperature and low relative humidity conditions (e.g., maximum power density of 176.4 mW cm−2 at 120 °C and 40% RH).
Osteoradionecrosis of the Jaw Following Proton Radiation Therapy for Patients With Head and Neck Cancer.

Importance Proton radiation therapy (PRT) has reduced radiation-induced toxic effects, such as mucositis and xerostomia, over conventional photon radiation therapy, leading to significantly improved quality of life in patients with head and neck cancers. However, the prevalence of osteoradionecrosis (ORN) of the jaw following PRT in these patients is less clear. Objective To report the prevalence and clinical characteristics of ORN in patients with oral and oropharyngeal cancer (OOPC) treated with PRT. Design, Setting, and Participants This case series reports a single-institution experience (Memorial Sloan Kettering Cancer Center, New York, New York) between November 2013 and September 2019 and included 122 radiation therapy-naive patients with OOPC treated with PRT. Data were analyzed from 2013 to 2019. Main Outcomes and Measures Clinical parameters, including sex, age, comorbidities, tumor histology, concurrent chemotherapy, smoking, comorbidities, and preradiation dental evaluation, were obtained from the medical record. Patients with clinical or radiographic signs of ORN were identified and graded using the adopted modified Glanzmann and Grätz grading system. Characteristics of ORN, such as location, clinical presentation, initial stage at diagnosis, etiology, time to diagnosis, management, and clinical outcome at the last follow-up, were also collected. Results Of the 122 patients (mean [SD] age, 63 [13] years; 45 [36.9%] women and 77 [63.1%] men) included in this study, 13 (10.6%) developed ORN following PRT during a median (range) follow-up time of 40.6 (<1-101) months. All patients had spontaneous development of ORN. At the time of initial diagnosis, grade 0, grade 1, grade 2, and grade 3 ORN were seen in 2, 1, 9, and 1 patient, respectively. The posterior ipsilateral mandible within the radiation field that received the full planned PRT dose was the most involved ORN site. At a median (range) follow-up of 13.5 (0.2-58.0) months from the time of ORN diagnosis, complete resolution, stable condition, and progression of ORN were seen in 3, 6, and 4 patients, respectively. The 3-year rates of ORN and death in the total cohort were 5.2% and 21.5%, while the 5-year rates of ORN and death were 11.5% and 34.4%, respectively. Conclusions and Relevance In this case series, the prevalence of ORN following PRT was found to be 10.6%, indicating that ORN remains a clinical challenge even in the era of highly conformal PRT. Clinicians treating patients with OOPC with PRT should be mindful of this complication.
Development of New Azomethine Metal Chelates Derived from Isatin: DFT and Pharmaceutical Studies

Through the condensation of isatin (indoline-2, 3-dione) and aniline in a 1:1 ratio, a Schiff base ligand was synthesized and characterized via (1H-NMR, mass, IR, UV-Vis) spectra. Elemental analyses, spectroscopy (1H-NMR, mass, UV-Vis), magnetic susceptibility, molar conductivity, mass spectra, scanning electron microscope (SEM), and thermal analysis have all been used to characterize a series of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) metal complexes derived from the titled ligand. The metal-to-ligand ratio is 1:1, according to the analytical data. The Schiff base ligand displayed bidentate behavior with NO coordination sites when it bonded to metal ions, as seen by the IR spectra. The magnetic moment measurement and UV-Vis spectral investigation showed the octahedral geometry of the Cr(III), Fe(III), Co(II), Ni(II), and Zn(II) complexes, whereas they suggested the tetrahedral geometry of the Mn(II), Cu(II), and Cd(II) complexes. The thermal analysis study confirmed the presence of both hydrated and coordinated water molecules in all the compounds, except for the Mn(II) complex, and showed that the complexes decomposed in three or five decomposition steps leaving the corresponding metal oxide as a residue. The ligand and its metal complexes’ antibacterial efficacy were evaluated. The findings showed that the metal complexes had stronger antibacterial properties than the ligand alone. The ligand and its metal complexes’ anticancer properties were also investigated. A DFT investigation is also reported to gather information regarding the electronic features of the ligand and its metal complexes. Finally, drug-likeness and ADME characteristics were also calculated as parameters.
Arnis-based Exercise Program for Balance Control in Community-Dwelling Older Adults: Study Protocol for a Pilot Randomized Controlled Trial

Background: Aging causes impairment in balance and increases the prevalence of falls in older adults. Martial arts are now incorporated into exercise programs to improve balance. Arnis, a Filipino Martial Art, can improve the balance control of older adults. Objectives: This study primarily aims to determine the effects of an Arnis-based exercise program on balance control of healthy community-dwelling older adults. This study also aims to describe its effect on older adults’ concerns about falling and lower limb functional strength. Methods: This will be a single-blind, pilot randomized controlled trial. Participants will be randomly allocated to either the intervention or control group. The intervention group will perform an Arnis-based exercise program for 40-60 minutes per session thrice a week for 12 weeks. The control group will continue to do their usual activities for the duration of the study. Participants will be measured at baseline and 12 weeks after for balance, concern for falling, and lower limb strength using the Berg Balance Scale, Timed-Up and Go Test, Falls Efficacy Scale-International Filipino, and the 30-second Chair Sit-to-stand Test, respectively. Data will be analysed through independent and paired t-tests. A p-value Expected Results: Significant improvements in the balance scores in the intervention group are expected after 12 weeks of the Arnis-based exercise program, along with its effects on concerns for falling and lower extremity strength. The pilot study will provide data on the effectiveness of Arnis as a reference for future larger experimental studies.