Miracle-dz/UniFAR-FTUs huggingface dataset:
Nonpropagating Form Drag and Turbulence due to Stratified Flow over Large-Scale Abyssal Hill Topography

Drag and turbulence in steady stratified flows over “abyssal hills” have been parameterized using linear theory and rates of energy cascade due to wave–wave interactions. Linear theory has no drag or energy loss due to large-scale bathymetry because waves with intrinsic frequency less than the Coriolis frequency are evanescent. Numerical work has tested the theory by high passing the topography and estimating the radiation and turbulence. Adding larger-scale bathymetry that would generate evanescent internal waves generates nonlinear and turbulent flow, driving a dissipation approximately twice that of the radiating waves for the topographic spectrum chosen. This drag is linear in the forcing velocity, in contrast to atmospheric parameterizations that have quadratic drag. Simulations containing both small- and large-scale bathymetry have more dissipation than just adding the large- and small-scale dissipations together, so the scales couple. The large-scale turbulence is localized, generally in the lee of large obstacles. Medium-scale regional models partially resolve the “nonpropagating” wavenumbers, leading to the question of whether they need the large-scale energy loss to be parameterized. Varying the resolution of the simulations indicates that if the ratio of gridcell height to width is less than the root-mean-square topographic slope, then the dissipation is overestimated in coarse models (by up to 25%); conversely, it can be underestimated by up to a factor of 2 if the ratio is greater. Most regional simulations are likely in the second regime and should have extra drag added to represent the large-scale bathymetry, and the deficit is at least as large as that parameterized for abyssal hills.
Retorno salarial e doenças cardiovasculares: evidências para o caso brasileiro

O objetivo deste artigo é analisar a relação entre doenças cardiovasculares e salários no Brasil, com base nos dados da Pesquisa Nacional de Saúde 2013. Esta relação é analisada adotando-se uma estratégia empírica em dois estágios. Em primeiro lugar, estima-se um propensity score matching para avaliar a probabilidade de um trabalhador reportar ter alguma doença cardiovascular. No segundo passo, é estimado um modelo de regressão quantílica incondicional, em que o escore de propensão é utilizado como peso para garantir as condições de balanceamento nos grupos de suporte comum. Os resultados indicaram que indivíduos que reportaram ter alguma doença cardiovascular têm perdas salariais em torno de 11%. As evidências encontradas indicam que a prevenção primária de doenças cardiovasculares melhorará os resultados no mercado de trabalho. Além disso, a prevenção e o tratamento secundários, se puderem reduzir as complicações da doença, também poderão ter um impacto significativo sobre o salário e o mercado de trabalho.
Characterization of down-valley windsin stable stratification from the KASCADE field campaign and WRF mesoscale simulations

Stable stratification can be one of the most penalizing condition concerning pollutants in the atmospheric boundary layer. Over complex terrain under these conditions, the relief may modify the flow. Therefore the knowledge of down-valley wind characteristics influencing the wind field at Cadarache and its close surroundings is crucial for safety regulation in the context of sanitary impact of the site. Cadarache is a CEA research centre and located in the Prealps of southeast France. It is embedded in a small valley, the Cadarache Valley (CV), which is one of the tributaries of the larger Durance Valley (DV). The two valleys are distinct in size and therefore react differently to stable conditions, and are investigated by means of observations (field experiment KASCADE : KAtabatic winds and Stability over CADarache for Dispersion of Effluents) and simulations (the Weather Research and Forecasting (WRF) model). To investigate the valley wind behaviour, the KASCADE campaign has been designed and conducted in the winter of 2013, covering a 3-month period and 23 intensive observation periods (IOP). It resulted in a well-documented campaign, from which the analysis shows that the Cadarache and Durance down-valley (CDV and DDV respectively) winds are both dominant flows during the period of investigation. The CDV wind is a thermally driven flow, with regular wind speeds up to 2 – 3 m s-1 up to 50 m agl. It persists throughout the night and disappears in the early morning with the stability. The current observational network of Cadarache lacks means of measurement for inside CDV wind. This work shows that it can be nowcasted from available meteorological tower observations. Due to the CV small scale, currently a wind forecast on kilometer resolution is out of reach, but the methodology developed here can be used to forecast the wind through a combination of dynamical and statistical downscaling. The DDV wind has been recognized as down-valley oriented, and strongly related to stability at a regional scale, as it exists only after sunset when synoptic forcing is very weak. DDV wind arrival at Cadarache is mostly observed 6 to 9 hours after sunset, but however dominantly present around sunrise, when convectively driven processes are not yet established. Jets are observed mostly at around 200 m agl with wind speeds between 4 and 8 m s-1. Despite some (general) deficiencies of the WRF model, the DDV wind is simulated close to reality thanks to the 1-km resolution allowing a correct representation of the Durance valley orography. The ensemble of 23 simulated IOPs allowed further to characterize the flow in a spatial sense and to recognize drainage and flow channelling as most important candidates for the flow mechanism.
A new Database of Water Level Time Series for Lakes, Rivers, and Wetlands from Multi-Mission Satellite Altimetry

Motivation Since many years satellite altimetry is becoming increasingly important for hydrology. The fact, that satellite altimetry, originally designed for open ocean application, can also contribute reliable results over inland waters helps to understand the water cycle of the system earth and makes altimetry to a very useful instrument for hydrology. In this poster, we present the new “Database for Hydrological Time Series of Inland Waters” (DAHITI). This database provides water level time series for lakes, rivers, reservoirs, and wetlands from multi-mission satellite altimetry which are computed by a Kalman Filter approach.
Multivariate Regular Variation and its applications by Diouldé Habibatou Mariko

In this thesis, we review the basic notions related to univariate regular variation and study some fundamental properties of regularly varying random variables. We then consider the notion of regular variation in the multivariate case. After collecting some results from multivariate regular variation for random vectors with values in R+, we discuss its properties and examine several examples of multivariate regularly varying random vectors such as independent and identically distributed random vectors, fully dependent random vectors and other models. We also present the elements of univariate and multivariate extreme value theory and emphasize the connection with multivariate regular variation. Some measures of extreme dependence such as the stable tail dependence function and the Pickands dependence function are presented. We end the study by conducting a data analysis using financial data. In the univariate case, graphical tools such as quantile-quantile plots, mean excess plots and Hill plots are used in order to determine the underlying distribution of the univariate data. In the multivariate case, non-parametric estimators of the stable tail dependence function and the Pickands dependence function are used to describe the dependence structure of the multivariate data.
UC Merced Proceedings of the Annual Meeting of the Cognitive Science Society

Across the world’s languages, children reliably learn nouns more easily than verbs. Attempts to understand the difﬁculty of verb learning have focused on determining whether the challenge stems from differences in the linguistic usage of nouns and verbs, or instead conceptual differences in the categories that they label. We introduce a novel metric to quantify the contributions of both sources of difﬁculty using unsupervised learning models trained on corpora of language and images. We ﬁnd that there is less alignment between the linguistic usage of verbs and their categories than for nouns and their categories. However, this difference is driven almost entirely by differences in the structure of their visual categories: Relative to nouns, events described by the same verb are more variable and events described by two different verbs are more similar. We conclude that differences between noun and verb learning need not be due to fundamental differences in learning processes, but may instead be driven by the difﬁculty of one-shot generalization from verbs’ visual categories.
CHAMPP4KIDS: Mixed methods study protocol to evaluate acceptability and feasibility of Parenting for Lifelong Health materials in a Canadian context

Background Parents and caregivers play a key role in children’s healthy development and well-being. Traditional parenting interventions promote positive parenting practices and are key to preventing child maltreatment. However, numerous barriers can limit access to programs, barriers which were further exacerbated by the COVID-19 pandemic. The Parenting for Lifelong Health group developed mass media and public health communication materials to promote positive caregiving behaviours on a population level. The Champions of Positive Parenting 4 Kids (CHAMPP4KIDS) study will examine the acceptability and feasibility of these materials for service providers and caregivers of children aged 2–6 years in Ontario, Canada. Methods This study will use a convergent mixed-methods design. Consenting service providers (n = 200) and caregivers (n = 100) will complete a quantitative survey to rate, rank and give feedback on Parenting for Lifelong Health tip sheets and social media ads. Caregivers will also complete self-report scales measuring depression and anxiety. We will hold focus group discussions with a sub-sample of surveyed providers (n = 40) and caregivers (n = 25). An adapted Trials of Improved Practices methodology will explore caregiver perspectives after implementing the tip sheets. Primary quantitative outcomes will be descriptive statistics of rankings, Likert Scale scores and descriptive analysis of caregiver depression and anxiety. Qualitative data will be analyzed using Rapid Qualitative Inquiry and triangulated through a convergent coding matrix. Discussion The Parenting for Lifelong Health COVID-19 parenting materials offer succinct, engaging parenting information in a mass media format that addresses some challenges associated with accessing in-person programming. The CHAMPP4KIDS study will provide mixed methods insights on the materials’ acceptability and feasibility from different groups in a Canadian context, with a focus on marginalized families. The use of Trials of Improved Practices methodology could prove a useful tool for participant-led adaptation of existing parenting, early childhood development and other health intervention materials.
A chimp algorithm based on the foraging strategy of manta rays and its application

To address the issue of poor performance in the chimp optimization (ChOA) algorithm, a new algorithm called the manta ray-based chimpa optimization algorithm (MChOA) was developed. Introducing the Latin hypercube method to construct the initial population so that the individuals of the initial population are evenly distributed in the solution space, increasing the diversity of the initial population. Introducing nonlinear convergence factors based on positive cut functions to changing the convergence of algorithms, the early survey capabilities and later development capabilities of the algorithm are balanced. The manta ray foraging strategy is introduced at the position update to make up for the defect that the algorithm is prone to local optimization, which effectively improves the optimization performance of the algorithm. To evaluate the performance of the proposed algorithm, 27 well-known test reference functions were selected for experimentation, which showed significant advantages compared to other algorithms. Finally, in order to further verify the algorithm’s applicability in actual production processes, it was applied to solve scheduling problems in three flexible workshop scenarios and an aviation engine job shop scheduling in an enterprise. This confirmed its efficacy in addressing complex real-world problems.
Detection of nitric oxide-mediated metabolic effects using real-time extracellular flux analysis

Dendritic cell (DC) activation is marked by key events including: (I) rapid induction and shifting of metabolism favoring glycolysis for generation of biosynthetic metabolic intermediates and (II) large scale changes in gene expression including the upregulation of the antimicrobial enzyme inducible nitric oxide synthase (iNOS) which produces the toxic gas nitric oxide (NO). Historically, acute metabolic reprogramming and NO-mediated effects on cellular metabolism have been studied at specific timepoints during the DC activation process, namely at times before and after NO production. However, no formal method of real time detection of NO-mediated effects on DC metabolism have been fully described. Here, using Real-Time Extracellular Flux Analysis, we experimentally establish the phenomenon of an NO-dependent mitochondrial respiration threshold, which shows how titration of an activating stimulus is inextricably linked to suppression of mitochondrial respiration in an NO-dependent manner. As part of this work, we explore the efficacy of two different iNOS inhibitors in blocking the iNOS reaction kinetically in real time and explore/discuss parameters and considerations for application using Real Time Extracellular Flux Analysis technology. In addition, we show, the temporal relationship between acute metabolic reprogramming and NO-mediated sustained metabolic reprogramming kinetically in single real-time assay. These findings provide a method for detection of NO-mediated metabolic effects in DCs and offer novel insight into the timing of the DC activation process with its associated key metabolic events, revealing a better understanding of the nuances of immune cell biology.
Lymph node harvesting after laparoscopic complete mesocolic excision colectomy in colon cancer with practical application of glacial acid, absolute ethanol, water, and formaldehyde solution: A prospective cohort study

Objectives: Quality of surgery has recently become an essential topic in the prognosis of colon cancer. Complete mesocolic excision for colon cancer has recently gained popularity with high-quality surgery. Patient specimens after complete mesocolic excision with central vessel ligation procedures have an integrity of the mesocolon and the yield of three fields of lymph node harvest. We apply the glacial acid, absolute ethanol, water, and formaldehyde solution to each specimen based on the Japanese classification of lymph node groups and station numbers. We aim to identify the distribution and status of lymph node metastasis according to each tumor site and some pathological characteristics related to this disease. Methods: A prospective cohort study was performed on 45 laparoscopic complete mesocolic excision surgery patients. Results: 2791 lymph nodes were harvested after complete mesocolic excision surgery. The average number was 62.0 ± 22.3 nodes. The mean tumor size (in the largest dimension) was 4.2 ± 1.8 cm. The average length of the resected bowel segments was 29.1 ± 7.7 cm. There are 63 (2.3%) node metastases in 2791 lymph nodes, in which 17/45 (37.8%) patients had pN(+). The minimum positive node size was 1 mm. The positive pericolic lymph nodes (station 1) accounted for the highest rate, with 53 nodes (1.9%). The number of lymph nodes in young age ⩽60 is more significant than in older. The results were similar, with a more significant node retrieval in the group with a tumor size >4.5 cm and specimen length >25 cm. The number of lymph nodes in lower tumor invasive (pT1,3) was smaller than pT4. Our research shows that the cecum, ascending, and descending colon had greater nodes than others, with a mean number of 78.6, 74.2, and 71.3, respectively. Conclusions: The metastasis and harvested lymph nodes accounted for the highest rate of colon cancer in station 1 and the lowest rate in station 3. The number of retrieved lymph nodes was significantly associated with tumor location, size, specimen length, and patient age.
Coxsackie B virus-induced myocarditis in a patient with a history of lymphoma: A case report and review of literature

Introduction: In rare occasions, coxsackievirus infections can cause serious illness, such as encephalitis and myocarditis. The immunotherapies of cancer could increase the risk of myocarditis, especially when applying immune checkpoint inhibitors. Herein, we report a rare case of Coxsackie B virus-induced myocarditis in a patient with a history of lymphoma. Case presentation: A 32-year-old woman was admitted to the hospital with recurrent fever for more than 20 days, and she had a history of lymphoma. Before admission, the positron emission tomography/computed tomography result indicated that the patient had no tumor progression, and she was not considered the cancer-related fever upon arriving at our hospital. Patient’s red blood cell, platelet count, and blood pressure were decreased. In addition, she had sinus bradycardia and 3 branch blocks, which was consistent with acute high lateral and anterior wall myocardial infarction. During hospitalization, the patient had recurrent arrhythmia, repeated sweating, poor mentation, dyspnea, and Coxsackie B virus were detected in patient’s blood samples by pathogen-targeted next-generation sequencing. The creatine kinase, creatine kinase MB, and N-terminal pro-brain natriuretic peptide were persistently elevated. Consequently, the patient was diagnosed with viral myocarditis induced by Coxsackie B virus, and treated with acyclovir, gamma globulin combined with methylprednisolone shock therapy, trimetazidine, levosimendan, sildenan, continuous pump pressors with m-hydroxylamine, entecavir, adefovir, glutathione, pantoprazole, and low-molecular-weight heparin. Her symptoms worsened and died. Conclusion: We reported a case with a history of lymphoma presented with fever, myocardial injury, who was ultimately diagnosed with Coxsackie B virus-induced myocarditis. Moreover, pathogen-targeted next-generation sequencing indeed exhibited higher sensitivity compared to mNGS in detecting Coxsackie B virus.
Association of white blood cell parameters with metabolic syndrome: A systematic review and meta-analysis of 168,000 patients

Background: Leukocyte parameters are predicted to be affected in patients with metabolic syndrome (MetS). We conducted a systematic review and meta-analysis to study the association between white blood cell parameters (WBC) in people with and without MetS. Methods: PubMed, EMBASE, Scopus and Cochrane Library databases were searched according to the study protocol. The standardized mean difference (SMD) and 95% confidence intervals (CI) of leukocyte markers between individuals with and without MetS were pooled using an inverse variance model. Additionally, a subgroup analysis by sex was performed where possible. Methodological quality assessment was conducted using the Newcastle-Ottawa scale (NOS) for observational studies and the Cochrane Risk of Bias tool 2.0 for Randomized Controlled Trials (RCTs). Results: Of 6068 articles identified, 63 were eligible for the study. Compared to controls, individuals with MetS showed significantly higher concentrations of total leukocyte count (SMD [95% CI]: 0.60 [0.55–0.65]; P < .00001; I2 = 100%), neutrophil counts (0.32 [0.28–0.37]; P < .00001; I2 = 99%), lymphocyte counts (0.15 [0.07–0.23]; P = .0004; I2 = 100%), basophil counts (0.01 [0.00–0.02]; P = .02; I2 = 98%), monocyte counts (0.05 [0.02–0.09]; P = .003; I2 = 99%), and neutrophil-to-lymphocyte ratio (0.24 [0.15–0.33]; P < .00001; I2 = 98%). There were no significant differences in the eosinophil count (0.02 [−0.01 to 0.05]; P = .19; I2 = 96%) and monocyte-to-lymphocyte ratio (0.06 [−0.05 to 0.17]; P = .27; I2 = 100%) between patients with and without MetS, however, the lymphocyte-to-monocyte ratio (0.52 [−0.81 to −0.23]; P = .0005; I2 = 52%) tended to be significantly lower in patients with MetS. Conclusion: Biomarkers such as total leukocyte count, neutrophil count, lymphocyte count, basophil count, monocyte count and neutrophil-to-lymphocyte ratio are associated with higher levels in patients in MetS and thus can potentially be used for early detection of MetS.
Why patients self-refer to the emergency service for nonurgency?: A mix-method survey from a family medicine perspective

The definition of “nonurgent emergency service visits” is visits to conditions for medical conditions that require attention but are not life-threatening immediately or severe enough to require urgent intervention. This study aims to investigate the reasons why patients choose to self-refer to the emergency service (ES) instead of their primary care health center for nonurgent complaints. The study was carried out in a tertiary hospital. The survey consisted of 2 parts with sociodemographic questions, knowledge of their family physician, and the reason why it has been applied to the ES with multiple choice answers. Of the 325 patients, the mean age was 34.5 years and 54.2% were women. Also, 26 of the patients were reported as “urgent” by the doctor. The main reasons underlying self-referred patients were classified into 4 themes: “urgency” (13.8%), advantages of ES (12.9%); disadvantages of primary care (25.1%), and other (45.9%). The most common reason patients self-refer to the ES was their belief in “being urgent” (61%). In this study, 26.8%, (n = 84) of the patients are not happy with their family physicians, while only 13.2% (N = 43) prioritize the ES advantages.
Segmentation de nuages de points 3D pour le phénotypage de tournesols

Cet article presente une methode de segmentation basee modele appliquee sur des nuages de points 3D de tournesols, l'objectif final etant la caracterisation de la croissance des tournesols. Ici, les acquisitions sont realisees sur des plantes isolees. Un nuage de points 3D est obtenu via Structure from Motion a partir d'images RGB acquises au- tour d'une plante. Ensuite, la methode proposee est appliquee afin de segmenter et de labelliser les feuilles, c'est-a- dire, regrouper le nuage de points en regions, une pour la tige et les autres pour les feuilles. Chaque feuille est ensuite reconstruite avec des NURBS et leurs surface est calculee a partir du maillage triangulaire resultant. Notre methode de segmentation est validee en comparant la surface obtenue via mesure manuelle realisee avec un planimetre, cette comparaison montre une difference inferieure a 10%. Ces resultats ouvrent une perspective interessante pour le phenotypage haut-debit des tournesols.