Miracle-dz/UniFAR-FTUs huggingface dataset:
Biocontrol of tomato bacterial wilt by a new strain Bacillus velezensis FJAT-46737 and its lipopeptides CURRENT STATUS: UNDER REVIEW

velezensis FJAT-46737, Abstract Background There is an urgent need to discover alternative antimicrobial agents to control bacterial wilt. The objectives of this study were to report a new FJAT-46737 and its lipopeptides, and to investigate their antagonistic effects. Results Based on the whole genome sequence analysis, the new strain FJAT-46737 was finally identified as Bacillus velezensis and seven gene clusters that responsible for synthesis of bioactive secondary metabolite in the FJAT-46737 were predicted. Antimicrobial results demonstrated that FJAT-46737 exhibited broad-spectrum antimicrobial activities in vitro against bacteria and fungi. The pot experiments showed that the tomato bacterial wilt control efficiencies of the whole cultures, the 2-fold diluted supernatants and the crude lipopeptide of FJAT-46737 were 66.2%, 82.0%, and 96.2%, respectively. The above results suggested that one of the antagonistic mechanisms of FJAT-46737 was secretion of lipopeptides that consisted of iturins, fengycins and surfactins. The crude lipopeptides had significant antagonistic activities on several pathogen in a dosage-dependent manner, and the fengycins confirmed to play a major role in antibacterial abilities in vitro of the lipopeptides against Ralstonia solanacearum . Furthermore, it was found that the rich organic nitrogen sources (expecially yeast extracts) in the media were benificial for FJAT-46737 to produce fengycin and surfactin. The secretion of these two lipopeptides were also adjusted by the culture temperature: the content of the fengycins decreased by 96.6% and that of the surfactins ascended by 59.9% from 20 o C to 40 o C. And 20 o C~25 o C is the suitable temperature for FJAT-46737 to produce lipopeptide.
Fermionic screenings and chiral de Rham complex on CY manifolds with line bundles

We represent a generalization of Borisov's construction of chiral de Rham complex for the case of line bundle twisted chiral de Rham complex on Calabi-Yau hypersurface in projective space. We generalize the differential associated to the polytope $\Delta$ of the projective space $\mathbb{P}^{d-1}$ by allowing nonzero modes for the screening currents forming this differential. It is shown that the numbers of screening current modes define the support function of toric divisor of a line bundle on $\mathbb{P}^{d-1}$ that twists the chiral de Rham complex on Calabi-Yau hypersurface.
Efficient Design of Keeper Circuit Using Wide Fan-In Gates

: In this paper, several circuits are proposed for wide fan-in gates, where the purpose is to achieve an efficient design. The technique which is utilized in this paper is based on the replacement of Si-MOSFET by CNTFET. Dynamic logic and Static logics are examined and verified for the better performance, the proposed circuit decreases the capacitance in dynamic node and increase its performance in desired fields. The proposed model decreases the parasitic capacitance on the dynamic node, yielding a smaller keeper for wide fan-in gates to implement fast and robust circuits. Thus, the contention current and consequently power consumption and delay are reduced. The average power and power dissipation is taken as parameters. Microwind and Hspice is used to analyze the results. The replacement of Si-MOSFETs by CNTFETs yields a decrease of 39% in the average power consumption.
COMPETITIVENESS OF LITHUANIAN FREIGHT TRANSPORT SERVICE SECTOR IN THE CONTEXT OF THE EUROPEAN UNION

Progressive changes, dynamic business environment become a constant of life in several economics spheres, including the Lithuanian freight transport service sector. Lithuanian freight transport services are characterized as sector acting on the terms of high rivalry. The aim of this article is to analyse the competitiveness of the Lithuanian freight transport sector in the context of the European Union. The competitive theoretical background, estimation of competitiveness of freight transport services are analysed. The competitive analysis of the sector through the Porter's model of five forces and internal characteristics of the enterprise defining the Lithuanian freight transport sector in terms of size and specialization is carried out. The methods of the research are systematics and a comparative analysis of scientific literature, quantitative research based on freight transport organisation survey. An empirical survey in which 349 freight transport service enterprises were examined allowed to reveal and estimate the most important factors influencing the competition intensity and the main firm-level factors that influence the companies' competitiveness in the economic sector.
ELECTROTEHNICS, ELECTRONICS, AUTOMATIC CONTROL, INFORMATICS SOME FREQUENCY DOMAIN CONSIDERATIONS UPON HUMAN RESPIRATORY MECHANICS

: The aim of this paper is to present a brief analysis of recent results considering human respiratory mechanics. The final purpose of the investigation is to provide a fast method for identification of airway mechanics, in order to assist the medical staff in obtaining a diagnosis of the patient within the context of performing routine evaluation of the respiratory function. Considerations are made with respect to the future potential of the method as a screening technique on a large number of populations.
NRAS mutations in AML: biology, cytogenetics, and prognosis a study on 2502 patients

In the presented study we analyzed 2502 patients with acute myeloid leukemia at diagnosis for NRAS mutations around the hot spots at codon 12, 13, and 61. We correlated the results to cytomorphology, cytogenetics, other molecular markers and prognostic relevance of these mutations. 257/2502 pts. (10.3%) showed NRAS mutations. The majority of mutations was found at codon 12 (n=112/257; 43.6%), mostly resulting in changes from glycine to asparagine. The history of AML did not differ significantly in association to NRAS mutations. The subgroups with inv(16)/t(16;16) and inv(3)/t(3;3) showed a significantly higher frequency of NRAS mut (50/133 (37.6%)(p<0.0001) and 11/41 (26.8 %) (p= 0.0004), respectively) when compared to the total cohort. In addition, in these two subgroups mutations of codon 61 were significantly overrepresented (both p<0.0001). In contrast NRAS mut were significantly underrepresented in t(15;17) (2/102; 2.0%) (p=0.0048), in the subgroup with MLL /11q23 rearrangements (3/77; 3.9%) (p=0.0616), and in complex aberrant karyotype (4/258; 1.6%) (p<0.0001). Overall we did not find a significant prognostic impact of NRAS mut for OS, EFS and DFS. However, there was a trend to better survival in most subgroups especially when other molecular markers ( FLT3 -LM, MLL-PTD and NPM ) were taken into account. further explored the frequency of NRAS mutations in patients with t(3;5). In total, 14 patients were found with this specific aberration; in 13/14 cases with complex aberrant karyotype and one patient with an isolated translocation. None of these 14 patients was NRAS positive. M4
Hepatitis C Virus NS2 Protein Contributes to Virus Particle Assembly via Opposing Epistatic Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme Complexes (cid:1)

The hepatitis C virus NS2 protein has been recently implicated in virus particle assembly. To further understand the role of NS2 in this process, we conducted a reverse genetic analysis of NS2 in the context of a chimeric genotype 2a infectious cell culture system. Of 32 mutants tested, all were capable of RNA replication and 25 had moderate-to-severe defects in virus assembly. Through forward genetic selection for variants capable of virus spread, we identiﬁed second-site mutations in E1, E2, NS2, NS3, and NS4A that suppressed NS2 defects in assembly. Two suppressor mutations, E1 A78T and NS3 Q221L, were further characterized by additional genetic and biochemical experiments. Both mutations were shown to suppress other NS2 defects, often with mutual exclusivity. Thus, several NS2 mutants were enhanced by NS3 Q221L and inhibited by E1 A78T, while others were enhanced by E1 A78T and inhibited by NS3 Q221L. Furthermore, we show that the NS3 Q221L mutation lowers the afﬁnity of native, full-length NS3-NS4A for functional RNA binding. These data reveal a complex network of interactions involving NS2 and other viral structural and nonstructural proteins during virus
TITLE: Hematopoiesis and immunity of HOXB4-transduced embryonic stem cell-derived hematopoietic progenitor cells

The ability of embryonic stem (ES) cells to form cells and tissues from all three germ layers can be exploited to generate cells that can be used to treat diseases. In particular, successful generation of hematopoietic cells from ES cells could provide safer and less immunogenic cells than bone marrow cells, which require severe host preconditioning when transplanted across MHC barriers. Here, we exploited the self-renewal properties of ectopically expressed HOXB4, a homeobox transcription factor, to generate hematopoietic progenitor cells (HPCs) that successfully induce high level mixed chimerism and long-term engraftment in recipient mice. The HPCs partially restored splenic architecture in Rag2 -/- γ c-/- immunodeficient mice. Additionally, HPC-derived newly generated T cells were able to mount a peptide-specific response to lymphocytic choriomeningitis virus (LCMV) and specifically secreted IL-2 and IFN- γ upon CD3 stimulation. In addition, HPC-derived antigen presenting cells (APCs) in chimeric mice efficiently presented viral antigen to wild type (WT) T cells. These results demonstrate for the first time that leukocytes derived from ES cells ectopically expressing HOXB4 are immunologically functional opening up new opportunities for the use of ES cell-derived HPCs in the treatment of hematological and immunological diseases. chimeric T that that partial
Institutional Knowledge at Singapore Management University PRESS: Personalized event scheduling recommender system (demonstration)

This paper presents a personalized event scheduling recommender system, PRESS, for a large conference setting with multiple parallel tracks. PRESS is a mobile application that gathers personalized information from a user and recom-mends talks/demos to be attend. The input from a user include a list of keyword preferences and (optionally) preferred talks. We use the MALLET topic model package to analyze the set of conference papers and classify them based on automatically identiﬁed topics. We propose an algorithm to generate a list of recommended papers based on the user keywords and the MALLET topics. An optimization model is then applied to obtain a feasible schedule. The recommended set is matched against the selected papers by the user which we obtained from a survey conducted at AAMAS-15 in Istanbul, Turkey. We show that PRESS is able to pro-vide reasonable accuracy, precision and recall rates. PRESS will be deployed live during AAMAS-16 in Singapore.
Bioﬁlm Formation and Acyl Homoserine Lactone Production in the Burkholderia cepacia Complex

Acyl homoserine lactone (acyl-HSL)-mediated gene regulation has been shown to inﬂuence bioﬁlm formation in one Burkholderia cepacia cystic ﬁbrosis isolate, but it is not known whether this relationship is a consistent feature of the several genomic species that make up the B. cepacia complex (BCC). We screened strains belonging to genomovars I to V of the BCC for bioﬁlm formation on an abiotic surface and for acyl-HSL synthesis. We determined that organisms from each of these genomovars were capable of bioﬁlm formation. Similarly, acyl-HSL was synthesized by organisms from each of genomovars I to V, with most isolates producing octanoyl-HSL in greatest abundance. When bioﬁlms were grown in Luria broth, acyl-HSL synthesis and bioﬁlm formation appeared to be associated, but these phenotypes were independent when the bioﬁlms were grown in basal salts containing citrate. Genomovar V strains synthesized the greatest quantities of acyl-HSL, and genomovar II and III-A strains elaborated the most abundant bioﬁlms. Quorum sensing may play a role in BCC pathogenesis, but it may not regulate bioﬁlm formation under all growth conditions.
Ruminal Microbiome Manipulation to Improve Fermentation Efficiency in Ruminants

The rumen is an integrated dynamic microbial ecosystem composed of enormous populations of bacteria, protozoa, fungi, archaea, and bacteriophages. These microbes ferment feed organic matter consumed by ruminants to produce beneficial products such as microbial biomass and short-chain fatty acids, which form the major metabolic fuels for ruminants. The fermentation process also involves inefficient end product formation for both host animals and the environment, such as ammonia, methane, and carbon dioxide production. In typical conditions of ruminal fermentation, microbiota does not produce an optimal mixture of enzymes to maximize plant cell wall degradation or synthesize maximum microbial protein. Well-functioning rumen can be achieved through microbial manipulation by alteration of rumen microbiome composition to enhance specific beneficial fermentation pathways while minimizing or altering inefficient fermentation pathways. Therefore, manipulating ruminal fermentation is useful to improve feed conversion efficiency, animal productivity, and product quality. Understanding rumen microbial diversity and dynamics is crucial to maximize animal production efficiency and mitigate the emission of greenhouse gases from ruminants. This chapter discusses genetic and nongenetic rumen manipulation methods to achieve better rumen microbial fermentation including improvement of fibrolytic activity, inhibition of methanogenesis, prevention of acidosis, and balancing rumen ammonia concentration for optimal microbial protein synthesis.
Workshop on childhood obesity: summary of the

Childhood obesity is rapidly emerging as a global epidemic that will have profound public health consequences as overweight children become overweight adults. To address this problem, action is needed at national and international levels. However, well-documented evidence of the trends in and global prevalence of obesity in children and adolescents is required to develop sound public health policies. There is no internationally acceptable index to assess childhood obesity nor is there an established cutoff point to define overweight in children. The purpose of the workshop was to establish a reasonable index with which to assess adiposity (overweight) in children and adolescents worldwide. We present here a summary of the discussion on the establishment of an index. The participants concluded that although body mass index (BMI; in kg/m 2 ) is not a perfect measure in children because it covaries with height, it has been validated against measurements of body density. Because a consistent and pragmatic definition for overweight in children and adolescents is required, BMI may therefore be appropriate. However, other alternatives may be considered in the future. The group suggested a scheme for cutoff points for children and adolescents based on internationally accepted BMI cutoff points for adult morbidity of 25 and 30 to identify grade 1 and grade 2 overweight, respectively. Use of these cutoff points would provide a new approach to identifying childhood obesity and make the definition for children and adolescents consistent with that for adults. Am J Clin Nutr 1999;70(suppl):173S–5S.
ORGANIZATIONAL COMMITMENT AND WORK MOTIVATION OF GOVERNMENT EMPLOYEES

This study was conducted to determine which domain of organizational commitment best predicts work motivation of government employees. The researchers used descriptive correlation method which includes a survey conducted with 120 government employees as participants. The adopted questionnaires which the respondents were asked to answer have been presented and validated. Mean, Pearson-r Correlation and Linear Regression were the statistical tools used in this research. The findings of the study revealed that government employees disclosed high level of organizational commitment and work motivation. Moreover, there is a significant relationship between organizational commitments and work motivation of government employees. Furthermore, organizational commitment significantly influences work motivation. Continuance commitment as domain of organizational commitment can singly influence work motivation.
chromatog-EFFECT OF DIETARy FISH OIL SUPPLEMENT ON REARINg PERFORMANCE OF yOUNg RABBITS AND QUALITy OF THEIR

The aim of the study was to determine the effect of essential unsaturated fatty acids (EUFA) in fish oil supplemented to doe diets on rearing per - formance of young rabbits and quality of their meat obtained at the end of growth at 90 days of age. Feeding a pelleted mixture containing 4% fish oil had a varying effect on rearing performance of young rabbits. It enabled better weight gains to be obtained at 21 and 35 days of age while having no effect on higher final weight on the day of slaughter. The fish oil supplement changed the fatty acid profile of intramuscular fat, increasing the level of n-3 PUFA, especially EPA and DHA acids, but this was paralleled by poorer sensory quality of meat.
tert -Butyl methyl ether

MAK value (2000) 50 ml/m (ppm) 180 mg/m Peak limitation (2000) Category I, excursion factor 1.5 Absorption through the skin – Sensitization – Carcinogenicity (2000) Category 3B Prenatal toxicity (2000) Pregnancy risk group C Germ cell mutagenicity – BAT value – Synonyms 2-methoxy-2-methylpropane methyl-tert-butyl ether Chemical name (CAS) tert-butyl methyl ether CAS number 1634-04-4 Structural formula (CH3)3C–O–CH3 Molecular formula C5H12O Molecular weight 88.15 Melting point –109°C Boiling point 55.2°C Density at 20°C 0.74 g/cm Vapour pressure at 25°C 335 hPa logPow* 0.94 1 ml/m (ppm) 3.66 mg/m 1 mg/m 0.273 ml/m (ppm)
BIROn - Birkbeck Institutional Research Online brain-sign: a physical alternative to

Consciousness and the mind are prescientific concepts that begin with Greek theorizing. They suppose human rationality and reasoning placed in the human head by (in Christian terms) God, who structured the universe he created with the same kind of underlying characteristics. Descartes‟ development of the model included scientific objectivity by placing the mind outside the physical universe. In its failure under evidential scrutiny and without physical explanation, this model is destined for terminal decline. Instead, a genuine biological and physical function for the brain phenomenon can be developed. This is the theory of brain-sign . It accepts the causality of the brain as its physical characteristics, already under scientific scrutiny. What is needed is a new neurophysiological mapping language that specifies the relation of the structure and operation of the brain to organismic action in the world. Still what is lacking is an account of how neurophysiologies in different organisms communicate on dynamic, i.e. unpredictable, tasks. It is this evolved capacity that has emerged as brain-sign. Thus rather than mentality being an inner epistemological parallel world suddenly appearing in the head, brain-sign, as the neural sign of the causal status of the brain, facilitates the communicative medium of otherwise isolated organisms. The biogenesis of the phenomenon emerges directly from the account of the physical brain, and functions as a monistic feature of organisms in the physical world. This new paradigm offers disciplinary compatibility, and genuine development in behavioral and brain sciences.
THE CONNECTION BETWEEN MATERNITY DISTRESS AND BREASTFEEDING THROUGH MOTHERHOOD

: Aim: In the United States, major burdensome turmoil influences one of every six ladies matured 22-42 years. During this childbearing a long time, melancholy can adversely impact maternal practices that are pivotal for newborn child development and development. This study explored the connection between maternity distress and breastfeeding through motherhood. Methods: Pregnancy Risk Assessment Management System (SPMS) details from Step 7 (2012-2013) has been analyzed (N=64 484). Pre-pregnancy stress was dichotomized, although breastfeeding was categorized as never breastfeeding, two months breastfeeding and around two months breastfeeding. Our research remained conducted at Sir Ganga Ram Hospital, Lahore from March 2019 to February 2020. Maternal age was the noteworthy impact modifier; hence, results were delineated by maternal age. Multinomial strategic relapse was utilized to get chances proportions and 96% certainty spans (CI). Results. For ladies matured 19-23, 24-28, and 30-34 years with pre-pregnancy sorrow, the chances of never breastfeeding and breastfeeding 8weeks or less were fundamentally higher than in women by not any record of pre-pregnancy misery. Outstandingly, among ladies matured 24-28 with pre-pregnancy wretchedness, the chances of never breastfeeding and breastfeeding two months or less were 94% (balanced chances proportion (AOR) = 1.93, 95% CI =1.58-2.38) and 66% (AOR = 1.66, 96% CI = 1.38-1.98) higher contrasted with ladies with no past of pre-pregnancy discouragement, individually. Conclusion: Having a past filled with poor emotional well-being before pregnancy may improve the probability of untimely breastfeeding suspension. A lady's psychological well-being status before pregnancy ought to be measured in conceptive and pre-birth care models. Endeavors ought to be made to comprehend difficulties ladies of explicit age bunches face once attempting to breastfeed.
a Coreceptor for HIV-1 Entry CXCR4, Suppresses, the Promoter Activity of USF/c-Myc Enhances, While Yin-Yang 1

Transcription factors USF1 and USF2 up-regulate gene expression (i.e., HIV-1 long terminal repeats) via interaction with an E box on their target promoters, which is also a binding site for c-Myc. The c-Myc oncoprotein is important in control of cellular proliferation and differentiation, while Yin-Yang 1 (YY1) has been shown to control the expression of a number of cellular and viral genes. These two proteins physically interact with each other and mutually inhibit their respective biological functions. In this study, we show that USF/c-Myc up-regulates, while YY1 down-regulates the promoter activity of CXCR4, a coreceptor for T cell-tropic HIV-1 entry. We have identiﬁed an E box around 2 260 and a YY1 binding site around 2 300 relative to the transcription start site. Mutation of the E box abolished USF/c-Myc-mediated up-regulation of CXCR4 promoter activity, and mutation of the YY1 binding site was associated with unresponsiveness to YY1-mediated inhibition. These data suggest that USF/c-Myc and YY1 may play an important role in the HIV-1-replicative cycle, by modulating both the viral fusion/entry process and viral expression. The Journal of Immunology, 1999, 162: 5986–5992.
Antiangiogenic Therapies for Advanced Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is a significant cause of death worldwide. HCC is a highly vascular tumor, and proangiogenic cytokines such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and fibroblast growth factor may play crucial roles in this disease. Sorafenib, a multikinase inhibitor that blocks VEGFandPDGF signaling,was the first systemic therapy to demonstrate improved survival in patients with advanced HCC. Several other drugs targeting VEGF are in development. Becauseof the anticipationof eventual resistance to anti-VEGF therapies, drugs that also target alternative proangiogenic pathways are being investigated. Recent clinical and preclinical data along with ongoing studies are reviewed. TheOncologist2013;18:430–438 Implications for Practice: Advanced hepatocellular carcinomas are refractory tomost anticancer agents. Targeting of angiogenesisappears tobethemostsuccessful strategytodate forextendingsurvival forpatientswithadvancedHCC.Thisarticlediscusses ongoing studies aimed at improving upon antiangiogenic therapy.