Miracle-dz/UniFAR-FTUs huggingface dataset:
OPTH_A_194234 1349..1355

Eric R Chen Peter K Kaiser 1School of Medicine, Case Western Reserve University, Cleveland, OH, USA; 2Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, USA Abstract: Age-related macular degeneration (AMD) is one of the leading causes of blindness in older adults worldwide. The advent of intravitreal neutralization of vascular endothelial growth factor (VEGF) has revolutionized the management of patients with neovascular AMD, but current anti-VEGF therapies carry a high threshold of patient burden. The ranibizumab port delivery system (PDS) is an implanted, refillable reservoir that continuously supplies the anti-VEGF medication ranibizumab directly into the vitreous, eliminating the need for frequent intravitreal injections. It has most recently been evaluated in the Phase II LADDER trial demonstrating the efficacy and safety of the PDS, with Phase III trials currently underway. This review presents both the promise and drawbacks of the PDS in the treatment of AMD from the current literature.
Exploiting Fully Convolutional Networks for Fast Road Detection

—Road detection is a crucial task in autonomous navigation systems. It is responsible for delimiting the road area and hence the free and valid space for maneuvers. In this paper, we consider the visual road detection problem where, given an image, the objective is to classify every of its pixels into road or non-road. We address this task by proposing a convolutional neural network architecture. We are especially interested in a model that takes advantage of a large contextual window while maintaining a fast inference. We achieve this by using a Network-in-Network (NiN) architecture and by converting the model into a fully convolutional network after training. Experiments have been conducted to evaluate the effects of different contextual window sizes (the amount of contextual information) and also to evaluate the NiN aspect of the proposed architecture. Finally, we evaluated our approach using the KITTI road detection benchmark achieving results in line with other state-of-the-art methods while maintaining real-time inference. The benchmark results also reveal that the inference time of our approach is unique at this level of accuracy, being two orders of magnitude faster than other methods with similar performance.
Staff Paper Series ’16-01 May 2016 In search of “Favorite-Long Shot Bias”: An experimental study of the demand for sweepstakes

This paper studies experimentally the demand for a variable-prize sweepstakes in which a single winner receives 90% of the total receipts, and whether such demand would exhibit the favorite-longshot bias (FLB) widely reported in the racetrack betting literature. We find significant incidence of sweepstakes purchase over population sizes ranging from 2 to 141, a greater tendency for FLB among those who exhibit longshot preference (LSP) over fixed-odds lotteries, but mixed support for FLB per se. In particular, the demand on average for 28-subject sweepstakes exceeds that of the largest one with 141 subjects including those who are averse to taking even-chance bets. Further and intriguingly, we observe significant demands for 2-person sweepstakes even among risk adverse subjects. Taken together, our observations reveal an incremental demand for sweepstakes arising from its interactive nature that can reinforce the effects of LSP as well as counter the effects of risk aversion.
Wearable Bluetooth Sensors for Capturing Relational Variables and Temporal Variability: A Construct Validation Study

The advent of wearable sensor technologies has the potential to transform organizational research by creating the unprecedented opportunity to collect continuous, objective, highly granular data over extended time periods. Recent evidence has demonstrated the potential utility of Bluetooth-enabled sensors in identifying emergent networks via co-location signals in highly controlled contexts with known distances and groups. Although there is proof of concept that wearable Bluetooth sensors may be able to contribute to organizational research in highly controlled contexts, to date there has been no explicit psychometric construct validation effort dedicated to these sensors in field settings. The two studies described here represent the first attempt to formally evaluate longitudinal Bluetooth data streams generated in an organizational setting, testing their ability to (a) show convergent validity with respect to traditional self-reports of relational data, (b) display discriminant validity with respect to qualitative differences in the nature of alternative relationships (i.e., advice versus friendship), (c) document predictive validity with respect to performance, (d) decompose variance in network-related measures into meaningful within and between unit variability over time, and (e) complement retrospective self-reports of time spent with different groups where there is a “ground truth” criterion. The results provide insights into the validity of Bluetooth signals with respect to capturing variables traditionally studied in organizational science, and highlight how the continuous data collection capabilities made possible by wearable sensors can advance research far beyond that of static perspectives necessitated by traditional data collection technologies.
OPTH_A_256963 3941..3953

1Department of Ophthalmology, Misr University for Science and Technology, October, Giza, Egypt; 2Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, Egypt Purpose: Optical coherence tomography (OCT) and OCTA were used for qualitative and quantitative assessment of retinal vascular density in superficial capillary plexus, deep capillary plexus, foveal avascular zone, and choroidal vascular density map. Patients and Methods: This study included 64 eyes. Diabetics and control groups were recruited from an internal medicine clinic at Misr University for Science and Technology Hospital and asked to participate in this study. This study was designed as an observational and cross-sectional study in the period from 8/2018 to 8/2019. Results: There was a decrease in choroidal vascular density in diabetic patients. There was a decrease in retinal thickness in diabetic patients and there were no significant differences in the retinal thickness between control subjects and patients with non-diabetic retinopathy (NDR). Conclusion: Our study suggests that OCTA can identify preclinical DR before the manifestation of clinically apparent retinopathy. Our findings also highlight the potential role of OCTA in monitoring and quantifying retinal vascular alterations in diabetics.
Design and Build Remote Watering System Based on Internet of Things (IoT) (Case Study Of Yogyakarta Code Tourism Park)

The combination of IoT (Internet of Things) technology and solar cell technology can be used to ease human work in everyday life. This research will design and build an Internet of Things (IoT)-based automatic plant sprinkler system by utilizing solar cells as electrical energy. The implementation of this system is carried out at the Code Tourism Park in Cokrodiningratan Village, Jetis District, Yogyakarta City. This research was conducted using the waterfall method with systematic stages. Solar panels have succeeded in producing AC electricity with a voltage of 220V so that it can be used to supply electricity to IoT device controllers. The watering mode consists of an automatic mode with a schedule that can be set from a web-based IoT platform and a remote watering mode via the internet. Both watering modes worked well and successfully watered the plants at the study site. For watering a garden with an area of 197.2 m2, the water consumption required per minute is approximately 20 liters. The coverage of watering plants in the Code Tourism Park is 197.2 m2. At the watering location, 15 sprinkler points are installed, so 1 sprinkler point can cover an area of approximately 13.15 m2.
A cross-attention based image fusion Network for prediction of mild cognitive impairment

Mild cognitive impairment (MCI) is the intermediate stage in the progression of Alzheimer’s disease, where patients exhibit cognitive decline, decreasing ability to perform complex daily tasks and other symptoms that can be mistaken for normal aging, thus missing the optimal time for treatment and leading to further deterioration of the patient’s condition. Structural magnetic resonance imaging (sMRI) and positron emission tomography (PET) are commonly used to examine patients in clinical practice. Currently, the fusion of sMRI and PET based on deep learning are simply extracting features individually and then fusing the extracted features, ignoring the correlation between features of two different modalities. Therefore, this paper proposes an image fusion method based on cross-attention mechanism, which makes it possible to focus not only on the features of its own view but also on the features of the other view during feature extraction to achieve dual-attempt cross-learning. The experimental results from the Alzheimer’s Disease Neuroimaging Initiative dataset show that the images fused based on the method proposed in this paper outperform the original method in three evaluation indexes: peak signal-to-noise ratio, structural similarity and classification accuracy.
Analysis of the IGBT Module with Bonding Wire Failure Based on Transient Thermal Impedance

Insulated gate bipolar transistor(IGBT) modules are widely used in inverters as power switching devices. In actual working conditions, the failure of bonding wires is one of the most common failure modes. In the current device reliability evaluation, the influence of bonding wire failure is ignored, which may easily cause the subsequent evaluation results to deviate from the reality. In this paper, the influence of the gradual failure of the bonding wire on the transient thermal impedance of the device is explored, and the electro-thermal coupling model of the device is constructed. The simulation results show that the transient thermal impedance of the device increases with the gradual failure of the bonding wire. An experimental platform for transient thermal resistance measurement was built to verify the accuracy of the simulation results.
Detection Method of Power Saving Mode of Household Photovoltaic-Storage Integrated Power Supply

Nowadays, more importance has been attached to the energy consumption of household energy storage inverters. This paper proposes a design scheme of original-auxiliary dual power supply for household energy storage inverters, so that the inverter uses a large-capacity power supply when it is loaded with medium or large loads, and uses a small-capacity power supply when it is loaded with light loads or no load, and avoids large losses caused by the two-stage inverter when using a large-capacity power supply with a small load with the purpose of energy saving. The solution adopts a peak detection circuit on the AC power supply side, which can accurately detect the tiny current when the 1∼3W-load is connected, so as to accurately judge the access and exit of the load, so that the power supply can enter or exit the power saving mode of the small-capacity power supply in a timely and flexible manner. In this paper, the feasibility and rationality of the scheme are tested by simulation, and it is proved that the power saving effect of the scheme is remarkable.
Envolvimento de equipes da atenção básica à saúde no controle da tuberculose

Este estudo objetivou analisar o envolvimento de equipes da Atencao Basica a Saude nas acoes de controle da tuberculose, ante a percepcao dos coordenadores do Programa de Controle da Tuberculose de nove municipios prioritarios do Estado de Sao Paulo. Trata-se de uma pesquisa qualitativa, cujos dados foram coletados em junho/2005 por meio de entrevista semi-estruturada com nove coordenadores e analisados pela tecnica de analise de conteudo-modalidade tematica. Os resultados apontaram dificuldades para incorporacao das acoes de controle da tuberculose, na atencao basica, relacionadas a debilidade quantitativa e qualitativa de recursos humanos e a visao centralizada e fragmentada da organizacao dessas acoes no sistema de saude. A integracao das atividades de controle da tuberculose na atencao basica sera possivel mediante organizacao do sistema de saude, seguindo os principios da atencao primaria e elaboracao/implementacao de uma politica de recursos humanos que garanta formacao e capacitacao continua das equipes de saude.
Evaluation of feeding response and growth performance of tilapia (Orechromis niloticus) that conditioned with color-assigned LED that associated with feeding and stressor

Conditioning can be applied as a management tool to increase the efficiency of aquaculture production by training the fish to gather into a designated site for feeding or harvesting purposes and reducing stress from handling or other external stressors that can be found in the ambient environment. While the use of conditioning in aquaculture can be beneficial, there is limited information on the application of this technology in tilapia. Thus, this research was conducted to evaluate the use of different color lights as positive and negative conditioning on feeding response and growth performance of tilapia. Treatment that used in this research is using random light at a random location that was independent of the random feeding location (P1); using blue color at a random location adjacent to the feeding location (P2); using similar treatment with P2 but with the incorporation of conditioning in the form of stress; and control treatment without conditioning. As the result, there is no significant difference among treatments in growth performance and feed conversion, and the application of these conditionings affects tilapia’s feeding response. Treatment P2 produces an improved feeding response compared to other treatments and incorporation of stress into treatment such as in treatment P3 may curb this improvement.
The Effect Characteristics Cetane Number of Commercial High-Speed Diesel Fuel-Biodiesel Palm Oil-Based Blends on CFR engine

Renewable energy is an important issue for substituting fossil fuels in the world. Biofuel is one of the most used fuels for transportation, mining, and the industrial sector. The government of Indonesia’s policy has mandatorily used biofuel for the blend to fossil fuel. Biodiesel production from palm oil base has good characteristics for substitute/blend to high-speed diesel (HSD) in the market. The objective of this study was to investigate the effects of cetane number value of variant HSD-biodiesel blend and the methodology with blending two types HSD and biodiesel (0%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 50%, 60%, 70%, 80%, 90%, 100%). The measurement of cetane number used a CFR engine in accordance with ASTM D 613. The result of this study was that the increasing percentage of biodiesel blend influenced the increasing value of cetane number, but the increasing value of cetane number was not linear. Therefore, biodiesel can be used as a cetane booster for HSD.
Uniaxial stress effect on quasi-one-dimensional Kondo lattice CeCo2Ga8

Quantum critical phenomena in the quasi-one-dimensional limit remain an open issue. We report the uniaxial stress effect on the quasi-one-dimensional Kondo lattice CeCo2Ga8 by electric transport and AC heat capacity measurements. CeCo2Ga8 is speculated to sit in close vicinity but on the quantum-disordered side of a quantum critical point. Upon compressing the c axis, parallel to the Ce–Ce chain, the onset of coherent Kondo effect is enhanced. In contrast, the electronic specific heat diverges more rapidly at low temperature when the intra-chain distance is elongated by compressions along a or b axis. These results suggest that a tensile intra-chain strain (εc > 0) pushes CeCo2Ga8 closer to the quantum critical point, while a compressive intra-chain strain (εc > 0) likely causes departure. Our work provides a rare paradigm of manipulation near a quantum critical point in a quasi-1D Kondo lattice by uniaxial stress, and paves the way for further investigations on the unique feature of quantum criticality in the quasi-1D limit.
Gaia Early Data Release 3: Summary of the contents and survey properties

We present the early installment of the third Gaia data release, Gaia EDR3, consisting of astrometry and photometry for 1.8 billion sources brighter than magnitude 21, complemented with the list of radial velocities from Gaia DR2. Gaia EDR3 contains celestial positions and the apparent brightness in G for approximately 1.8 billion sources. For 1.5 billion of those sources, parallaxes, proper motions, and the (G_BP-G_RP) colour are also available. The passbands for G, G_BP, and G_RP are provided as part of the release. For ease of use, the 7 million radial velocities from Gaia DR2 are included in this release, after the removal of a small number of spurious values. New radial velocities will appear as part of Gaia DR3. Finally, Gaia EDR3 represents an updated materialisation of the celestial reference frame (CRF) in the optical, the Gaia-CRF3, which is based solely on extragalactic sources. The creation of the source list for Gaia EDR3 includes enhancements that make it more robust with respect to high proper motion stars, and the disturbing effects of spurious and partially resolved sources. The source list is largely the same as that for Gaia DR2, but it does feature new sources and there are some notable changes. The source list will not change for Gaia DR3. Gaia EDR3 represents a significant advance over Gaia DR2, with parallax precisions increased by 30 percent, proper motion precisions increased by a factor of 2, and the systematic errors in the astrometry suppressed by 30--40 percent for the parallaxes and by a factor ~2.5 for the proper motions. The photometry also features increased precision, but above all much better homogeneity across colour, magnitude, and celestial position. A single passband for G, G_BP, and G_RP is valid over the entire magnitude and colour range, with no systematics above the 1 percent level.
In Vivo and In Vitro Specificity of Protein Tyrosine Kinases for Immunoglobulin G Receptor (FcgRII) Phosphorylation

Human B cells express four immunoglobulin G receptors, FcgRIIa, FcgRIIb1, FcgRIIb2, and FcgRIIc. Coligation of either FcgRII isoform with the B-cell antigen receptor (BCR) results in the abrogation of B-cell activation, but only the FcgRIIa/c and FcgRIIb1 isoforms become phosphorylated. To identify the FcgRIIphosphorylating protein tyrosine kinase (PTK), we used the combination of an in vitro and an in vivo approach. In an in vitro assay using recombinant cytoplasmic tails of the different FcgRII isoforms as well as tyrosine exchange mutants, we show that each of the BCR-associated PTKs (Lyn, Blk, Fyn, and Syk) shows different phosphorylation patterns with regard to the different FcgR isoforms and point mutants. While each PTK phosphorylated FcgRIIa/c, FcgRIIb1 was phosphorylated by Lyn and Blk whereas FcgRIIb2 became phosphorylated only by Blk. Mutants lacking both tyrosine residues of the immune receptor tyrosine-based activation motif (ITAM) of FcgRIIa/c were not phosphorylated by Blk and Fyn, while Lyn-mediated phosphorylation was dependent on the presence of the C-terminal tyrosine of the ITAM. Results obtained in assays using an FcgR B-cell line transfected with wild-type or mutated FcgRIIa demonstrated that exchange of the C-terminal tyrosine of the ITAM of FcgRIIa/c was sufficient to abolish FcgRIIa/c phosphorylation in B cells. Additionally, we could show that Lyn and Fyn bind to FcgRIIa/c, with the ITAM being necessary for association. Comparison of the phosphorylation pattern of each PTK observed in vitro with the phosphorylation pattern observed in vivo suggests that Lyn is the most likely candidate for FcgRIIa/c and FcgRIIb1 phosphorylation in vivo.
Draft Development and evaluation of SNP panels for the detection of hybridization between wild and escaped Atlantic salmon ( Salmo salar ) in the West Atlantic

Complete List of Authors: Wringe, Brendan; Northwest Atlantic Fisheries Centre, Fisheries and Oceans Canada; Bedford Institute of Oceanography Anderson, Eric; National Marine Fisheries Service, Southwest Fisheries Science Center Jeffery, Nicholas; Northwest Atlantic Fisheries Centre, Fisheries and Oceans Canada Stanley, Ryan; Bedford Institute of Oceanography, Habitat Ecology Section Bradbury, Ian; Northwest Atlantic Fisheries Centre, Fisheries and Oceans Canada
A Case of Linaclotide and Intestinal Obstruction

Linaclotide is safe medication used in the treatment of constipation. Diarrhea is the most common side effect. A patient with prior multiple abdominal surgery developed small bowel obstruction after taking Linaclotide. Conductance Regulator (CFTR) ion channel, and inhibits absorption of sodium, resulting in increased intestinal fluid secretion and accelerated GI transit [3]. Thus Linaclotide can cause secretory type of diarrhea. Extracellular cGMP also decreases the sensitivity of pain-sensing nerves and reduces visceral hypersensitivity. Clinical trial demonstrated that Linaclotide could decrease abdominal pain, bloating and constipation [4]. Linaclotide minimally absorbed from the gut. The different adverse effects are diarrhea (16-20%), abdominal pain (7%), flatulence (4 to 6%), headache (<2 to 4%), abdominal distension (2 to 3%), fecal incontinence (1 to<2%), GERD (1 to 2%), viral gastroenteritis (1 to <2%), sinusitis (2 to 3%), dyspepsia (1 to <2%) and fecal incontinence (1 to <2%). The patient presented with idiopathic constipation without having any evidence of small bowel obstruction. She was prescribed Linaclotide to help moving her bowel. On literature search, no case of small bowel obstruction was found in relation to ingestion of Linaclotide. In our case, the temporal relationship between Linaclotide intake and small bowel obstruction may suggest that Linaclotide precipitated the development of small bowel obstruction. Our patient had multiple intra-abdominal surgeries with formation of adhesion and bands. She received docusate sodium for her constipation in the setting of previous surgeries but she did not develop intestinal obstruction. So from the clinical experience, it would be advisable to avoid Linaclotide in patients with multiple intra-abdominal surgeries. Further studies will be needed to find out whether Linaclotide is safe in patients with multiple intra-abdominal surgeries.
OP-EHEA210428_online 4126..4138

Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Box 9600, Leiden 2300 RC, The Netherlands; Department of Haematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands; and Department of Internal Medicine, Section of Thrombosis and Haemostasis, Leiden University Medical Center, Albinusdreef 2, Box 9600, Leiden 2300 RC, The Netherlands
Requirement of IL-7 for IL-4-producing potential of MHC class I-selected CD4 –CD8– TCRαβF thymocytes

IL-7 plays an important role in the growth and differentiation of T cells. We have previously reported that IL-7 induces preferential expansion of MHC class I-selected CD4 –CD8–TCRαβF thymocytes which express a skewed V β repertoire and are potent IL-4 producers. In this report, we provide evidence that IL-1 in combination with granulocyte macrophage colony stimulating factor can also expand this population. Yet, these cells do not share the functional characteristics of those obtained in the presence of IL-7, i.e. cytotoxic activity and high IL-4 production. These functional capacities can be acquired by adding IL-7. In conclusion, our findings demonstrate that the capacity of MHC class I-selected CD4 –CD8–TCRαβF thymocytes to produce IL-4 as well as to kill target cells is IL-7 dependent.