Miracle-dz/UniFAR-FTUs huggingface dataset:
Adaptive neuro fuzzy inference system modelling of multi-objective optimisation of electrical discharge machining process using single-wall carbon nanotubes

Abstract Electrical discharge machining (EDM) has new avenues for finishing of hard and brittle materials with nano surface finish, high tolerance and accuracy. The single-wall carbon nanotube (SWCNT) is mixed with kerosene dielectric fluid in die sinking EDM process. The analysis of surface characteristics like surface roughness and metal removal rate of AISID2 tool steel materials were carried out and an excellent machined nano finish can be obtained by setting the machining parameters at optimum level. This study deals with modelling of surface roughness with SWCNT-based EDM using adaptive neuro fuzzy inference system approach. The first-order Sugeno-type fuzzy interference modelling has been used to predict the output parameters and compared with experimental values. The R2 value of regression model for with CNT is 0.706 and for without CNT is 0.652. The high R2 indicate that better model fit the data very well using CNT-based machining. The proposed model can also be used for estimating surface roughness and metal removal rate online.
Indolium 1 Exerts Activity against Vemurafenib-Resistant Melanoma In Vivo

The development of targeted therapies (BRAF/MEK inhibitors) and immunotherapy have had a major impact on the treatment of melanoma. However, the majority of patients with advanced melanomas succumb to their disease. The mechanisms of resistance to both targeted therapies and immunotherapies are numerous and have been well-described. These include the alternative activation of BRAF/MEK signaling, novel compensating mutations in additional oncogenes, and loss of neoantigens. There has been limited development of small molecules that target alternative pathways in melanoma in the last two decades. We have previously identified triphenylmethanes as a class that shows activity against a wide variety of tumors. We have synthesized a novel triphenylmethane, indolium 1, and demonstrated its efficacy against an aggressive vemurafenib-resistant melanoma in vivo. Indolium 1 has a novel mechanism of action against melanoma, in that it results in induction of the tumor-suppressor EPHA3. We believe that pre-IND studies are warranted for this novel compound, given its mechanism of action and ability to inhibit the growth of vemurafenib resistant melanoma in vivo.
Respiratory Adsorption of Organic Pollutants in Wastewater by Superhydrophobic Phenolic Xerogels

Organogel adsorbents are widely used for the adsorption of hard-to-degrade organic pollutants in wastewater due to their natural affinity to the organic phase in water. In this study, phenolic xerogels (PF) synthesised in the ethylene glycol inorganic acid system are used as a backbone and superhydrophobic phenolic xerogels (ASO-PF) are obtained by grafting aminosilanes onto the PF backbone via the Mannich reaction. The modified ASO-PF not only retains the pore structure of the original PF (up to 90% porosity), but also has excellent superhydrophobic properties (water contact angle up to 153°). Owing to the unique pore structure, ASO-PF has excellent compression properties, cycling 50% compression deformation more than 10 times without being damaged, with a maximum compression deformation of up to 80%. A squeeze–suction–squeeze approach is proposed for selective adsorption of organic pollutants in homogeneous solutions based on the recyclable compression properties of ASO-PF. The ASO-PF is put under negative pressure by squeezing, and when the pressure is released, the adsorbed liquid enters the ASO-PF, where the organic pollutants are retained by the adsorption sites in the skeleton, and then the remaining water is discharged by squeezing. This breathing ASO-PF holds great promise for organic pollutant adsorption and recovery applications.
Effects of Different Low-Intensity Exercise Types on Duration, Energy Expenditure and Perceived Exertion in Obese Individuals

Physical exercise is a common strategy in overweight and obesity management. Exercise type, intensity, duration, energy expenditure and the rate of perceived exertion (RPE) are the essential determinants of exercise efficiency. The purpose of the present study was to compare continuous and intermittent exercises targeted at the maximal fat oxidation intensity (FAT max) in obese individuals. Ten obese males (BMI > 30 kg/m2; age: 19 to 35 years) who maintained a sedentary lifestyle were recruited for this study to perform three separate exhaustive exercises: a continuous exercise at FAT max (CON), an intermittent exercise that alternates two minutes at FAT max −10% with one minute at FAT max +20% (INT½), and a second intermittent exercise that alternates four minutes at FAT max −10% with one minute at FAT max +40% (INT¼). The duration of the INT¼ exercise (65.1 min ± 13.4) was significantly longer than that of the CON exercise (55.4 min ± 6.0). No significant difference in the total amount of energy expenditure was observed across the three types of exercise (CON: 372 Kcal ± 98.2, INT¼: 398 Kcal ± 145.5, INT½: 374.4 Kcal ± 116.1). The fat oxidation rate after 45 min during the INT exercises (INT¼: 93.0 ± 19.1 mg/min, INT½: 71.1 ± 15.6 mg/min) was significantly higher than that of the CON exercise (36.1 ± 12.2 mg/min). The CON exercise was less well tolerated. The rate of perceived exertion (RPE) at the end of the CON (15.8 ± 2) was significantly higher than that of the INT exercises (13.5 ± 2 for the INT¼ and 13.1 ± 1.8 for the INT½). The INT exercises were more efficient in terms of duration, fat oxidation and RPE.
The Current Level of HIV/AIDS Knowledge and Sexual Behaviors of Students in Southern China: A Cross-Sectional Study

BACKGROUND: The spread of HIV/AIDS in China is predominantly driven by sexual transmission and it is a fact that HIV transmission among students is quite common, e.g., 480 000 adolescents were infected from 2000 to 2018. Our study aimed to investigate knowledge of HIV/AIDS and sexual behaviors of young students in Southern China. METHODS: A cross-sectional study was conducted based on questionnaire. The information collected included socio-demographic characteristics, knowledge of HIV and risky sexual behaviors. RESULTS: 9027 students were invited and 8349 were eventually enrolled in the study. The following factors were found to be associated with lower level of HIV/AIDS knowledge: female (OR: 0.757, 95% CI 0.689–0.831), residence in rural areas (OR: 0.786, 95% CI: 0.713–0.866), studying in high school (OR = 0.598, CI =0.459–0.779) and secondary vocational school (OR =0.713, CI =0.545–0.933), major in pharmacy (OR = 0.453, CI = 0.331–0.621), medicine (OR = 0.592, CI = 0.402–0.872) and others (OR = 0.671, CI = 0.518–0.871), and little participation in programs for the prevention of AIDS (OR = 0.646, CI = 0.585–0.714). Kendall correlation test showed that students who had risky sexual behaviors all had lower level of HIV/AIDS Knowledge (P < 0.05). CONCLUSIONS: Students who have more knowledge of HIV/AIDS were generally less likely to have risky sexual behaviors. Female students and those who reside in rural areas had lower level of HIV/AIDS knowledge, indicating that we may need to pay more attention to deliver education for these cohorts. It is suggested to follow the strategies used by some developed countries to improve students’ knowledge for HIV/AIDS and prevent its transmission.
Allergic conjunctivitis in contact lens wearers: challenges and management recommendations

ABSTRACT Introduction Giant papillary conjunctivitis (GPC), which is the most severe type of contact lens–induced (CL) papillary conjunctivitis (CLPC), is an inflammatory condition of the upper tarsal conjunctiva. Major symptoms of CLPC include irritation, pain, itching, and redness of the ocular surface. Area covered This review provides an update on our current understanding of the pathogenesis and treatment of GPC. Expert opinion GPC is most often associated with the use of non-disposable soft contact lenses (SCL), or soft hydrogel lenses, and infrequent CL replacement. Patients with GPC may require both temporary cessation of CL wear and treatment with medications such as topical mast cell stabilizers, antihistamines, non-steroidal anti-inflammatory agents, or steroids.
The Role of the Multidisciplinary Health Care Team in the Management of Patients with Systemic Sclerosis

Abstract Systemic sclerosis (SSc) is a rare connective tissue disease characterised by immune dysfunction, vascular damage and fibrosis affecting the skin and multiple internal organs. The clinical spectrum of SSc is wide and its manifestations may lead to severe morbidity and mortality, in addition to a great impact on patients’ quality of life. Due to the multifaceted clinical manifestations of SSc, its management requires a combined expertise of different medical specialists to guarantee an adequate disease control and prevent organ complications. Multi-disciplinary teams (MDT), which are composed by physicians and other specialized health professionals, represent therefore a key element for the comprehensive management of SSc patients. Moreover, MTD can improve communication and patients’ empowerment while the presence of dedicated nurses can help patients to ask questions about their condition. The scope of this narrative review is to analyse the available evidences regarding the role of MDT in the management of SSc patients, and how this holistic approach may improve different disease domains and the overall prognosis. MDT regarding the cardiovascular and lung complication are the more represented in literature, given the great impact in prognosis. Nonetheless, MDT have been shown to be fundamental also in other disease domains as they can intercept early manifestations, thus stratifying patients based on the individual risks in order to personalize patients’ follow-up. MDTs may also minimize the treatment delay, enabling fast-track specialist referral. On the other hand, there are few trials specifically studying MDT in SSc and several authors have highlight the lack of standardization.
Enactive Authorship

The neurocinematic inquiry is extended in this article to the sparsely studied topic of the filmmaker (author) as an embodied agent. Departing from my concept of second-order authorship, and inspired by the second-person framework of intersubjectivity discussed by Michael Pauen and Vittorio Gallese, I propose a model in which the author simulates the viewer (experient) who further simulates the experience of the protagonist in the film. This chain of relations is described as enactive second-order simulation of the viewer experience. While the author does not have a direct key to influence the experient, there is a relation mediated by the protagonist’s situatedness in the film’s narrative context. I further trust the core assumption of the neurocinematic approach—namely, that film as a narrative medium provides a means to imitate contexts of life that condition the enactive simulation of both the author and the experient.
Survey of Cooperative Advanced Driver Assistance Systems: From a Holistic and Systemic Vision

The design of cooperative advanced driver assistance systems (C-ADAS) involves a holistic and systemic vision that considers the bidirectional interaction among three main elements: the driver, the vehicle, and the surrounding environment. The evolution of these systems reflects this need. In this work, we present a survey of C-ADAS and describe a conceptual architecture that includes the driver, vehicle, and environment and their bidirectional interactions. We address the remote operation of this C-ADAS based on the Internet of vehicles (IoV) paradigm, as well as the involved enabling technologies. We describe the state of the art and the research challenges present in the development of C-ADAS. Finally, to quantify the performance of C-ADAS, we describe the principal evaluation mechanisms and performance metrics employed in these systems.
Review of Real-Time Biomechanical Feedback Systems in Sport and Rehabilitation

Real-time biomechanical feedback (BMF) is a relatively new area of research. The potential of using advanced technology to improve motion skills in sport and accelerate physical rehabilitation has been demonstrated in a number of studies. This paper provides a literature review of BMF systems in sports and rehabilitation. Our motivation was to examine the history of the field to capture its evolution over time, particularly how technologies are used and implemented in BMF systems, and to identify the most recent studies showing novel solutions and remarkable implementations. We searched for papers in three research databases: Scopus, Web of Science, and PubMed. The initial search yielded 1167 unique papers. After a rigorous and challenging exclusion process, 144 papers were eventually included in this report. We focused on papers describing applications and systems that implement a complete real-time feedback loop, which must include the use of sensors, real-time processing, and concurrent feedback. A number of research questions were raised, and the papers were studied and evaluated accordingly. We identified different types of physical activities, sensors, modalities, actuators, communications, settings and end users. A subset of the included papers, showing the most perspectives, was reviewed in depth to highlight and present their innovative research approaches and techniques. Real-time BMF has great potential in many areas. In recent years, sensors have been the main focus of these studies, but new types of processing devices, methods, and algorithms, actuators, and communication technologies and protocols will be explored in more depth in the future. This paper presents a broad insight into the field of BMF.
The Rationales Behind the EU-OACPS Agreement: Process, Outcome, Contestations

This article examines the rationales of the European Union (EU) and the Organisation of African, Caribbean and Pacific States (OACPS) in the preparations and negotiations of the successor to the Cotonou Agreement, paying particular attention to contested issues. It argues that the EU-OACPS Agreement constitutes a fundamental break from past practices, at least apparently: with regards to form, it introduces an unprecedented framework for cooperation, articulated in a common base with three distinct regional pillars; in terms of substance, it proposes a list of equally important strategic priorities, thus going beyond the previous focus on development. Furthermore, unlike its predecessor but like many other agreements signed by the EU with third states, it sets out a comprehensive political partnership for mutually beneficial outcomes. This article, importantly, unravels sources of tensions between and within the two sides. It also shows that negotiations were more symmetrical than in previous instances, not least because contentious issues such as aid volumes and trade cooperation fall outside the remit of the EUOACPS Agreement, and less participatory, as they were largely conducted by a small number of official representatives, with limited involvement of other stakeholders. EU-OACPS Agreement, Cotonou Agreement, post-Cotonou, ACP Group, African Union, EU development policy
A VHDL Implementation of Low Power Virus Detection Processor

Nowadays, mobile handsets combine the functionality of mobile phones and PDAs. Unfortunately, mobile handsets development process has been driven by market demand, focusing on new features and neglecting security. So, it is imperative to study the existing challenges that facing the mobile handsets threat containment process, and the different techniques and methodologies that used to face those challenges and contain the mobile handsets malwares. A TCAM-basedvirus-detection unit provides high throughput, but also challengesfor low power and low cost. In this paper, an adaptively dividable edual-port BiTCAM (unifying binary and ternary CAMs) isproposed to achieve a high-throughput, low-power, and low-costvirus-detection processor for mobile devices. The proposed dual-port BiTCAM is realized with the dual-port AND-type match-line scheme which is composed of dual-port dynamicAND gates. The dual-port designs reduce power consumptionand increase storage efficiency due to shared storage spaces.In addition, the dividable BiTCAM provides high flexibility for regularly updating the virus-database
AN OVERVIEW OF THE CURRENT PROGRESS OF THE HEI’S SUPPORT SYSTEMS FROM THE ENTRANTS’ PERSPECTIVES

One of the strategically important processes of the higher education institution activity is the enrollment campaign. In the information and knowledge society, the effectiveness of its implementation depends on many factors, one of which is the use of information technology. Therefore, the purpose of this paper is to examine current researches and determine the existing trends aims to support the decision-making of HEI`s and major from entrants perspective. This literature review uses Scopus and Web of Science databases and Google Scholar web search engine. Major findings include three lines of research that generate contributions on this topic: predicting the success of admission, recommendation of the major or education institution, and investigation of factors influencing the entrant`s choice. The review indicates that the most common is the use of data mining to solve researches tasks. The results of this study allow us to identify key points that are critical at the initial stage of solving decision support issues and to detect the main future directions of research.
Sviluppo di un impianto pilota per la produzione di microalghe: misure di laboratorio e progetto di impianto. Development of a pilot plant for microalgae production: laboratory measurements and plant design

Il tema della produzione industriale di microalghe e stato affrontato dapprima attraverso un approccio sperimentale e successivamente con la messa a punto di un modello di simulazione. In particolare, reattori in scala di laboratorio sono stati appositamente costruiti per la coltivazione di alghe e sono stati condotti test in condizioni di funzionamento sia batch che continue. I programmi di simulazione hanno permesso di utilizzare un modello per simulare l'attenuazione della luce lungo la profondita della coltura microalgale e per correlare i parametri del modello sui dati sperimentali ottenuti con il reattore continuo con riciclo. Le prestazioni del reattore in questione sono state valutate attraverso l'efficienza fotosintetica e il bilancio di energia. I parametri ottimizzati del modello hanno permesso di approfondire il comportamento di una coltura microalgale in un fotobioreattore pilota, simulando sia la luce artificiale sia i cicli giorno/notte con luce solare
Double Pre-Bending of an Intramedullary Nail Is the Minimal Invasive Osteosynthesis Solution for Dia-Metaphyseal Fractures of the Radius in Children: Technical Note and Case Series

Whereas in paediatric traumatology for diaphyseal fractures of the radius (intramedullary nail), as well as metaphyseal fractures (K-wire), minimal invasive methods for osteosynthesis were established as gold standard, the ideal osteosynthesis of fractures of the dia-metaphyseal area remains controversial. In this article, the author describes his own minimal invasive technique, using an intramedullary nail that must be pre-bent twice to achieve a stable reduction, with three-point support. The material used for this new surgical technique is an ordinary intramedullary nail. If not available, the operation can also be performed with a sufficiently lengthy K-wire. The intramedullary nail needs to be pre-bent twice, which follows a standardised procedure. A small case series is included to visualise the scope of this minimal-invasive method.
Structural Equation Modeling (SEM) and Temporal Dominance of Sensations (TDS) in the Evaluation of DOC Douro Red Wine’s Sensory Profile

In the Portuguese Douro region, several DOC (Denomination of Controlled Origin) Douro red wines are produced and, due to the peculiar characteristics of the three Douro sub-regions, present particular imprinted terroirs, that can be perceived when tasted. Considering the DOC Douro wine’s sensory profile and terroir, this study aimed to analyze the sensory characteristics of red wines produced in the three Douro sub-regions (Baixo Corgo, Cima Corgo, and Douro Superior) by a single point sensory technique, a Quantitative Descriptive Analysis—QDA® and also applying a temporal method-TDS (Temporal Dominance of Sensations). The use of QDA and TDS methods proved to be efficient in the wine’s sensory profile characterizing. The QDA® method allowed a detailed classification of attributes; however, the TDS method proved to be much more efficient. Moreover, the wines of the three sub-regions presented profiles with characteristics very similar in olfactory and taste/flavor aspects, pointing out a huge relation between the characteristics of the three sub-regions and the grape varieties present in the wines. Globally, the olfactory profile of wines is characterized by Fruity, Floral, and Balsamic aromatic notes, while the taste/flavor profile stands out, highlighting Astringency and Acidity and, again, Fruity as the main in-mouth aroma. It was also possible to conclude that TDS is a fast method that is easy to apply and has excellent results in the evaluation of the olfactory and taste/flavor profile of wines and, with a larger set of samples, it would be possible to obtain characteristic TDS curves for each Douro sub-region, providing a wine’s fingerprint that could be used for authentication and traceability purposes.
Charge Management Optimization for Future TOU Rates: Preprint

The effectiveness of future time of use (TOU) rates to enable managed charging for providing demand response depends on the vehicle's flexibility and the benefits to owners. This paper adopts opportunity, delayed, and smart charging methods to quantify these impacts, flexibilities, and benefits. Simulation results show that delayed and smart charging methods can shift most charging events to lower TOU rate periods without compromising the charged energy and individual driver mobility needs.
Test Optimization in Memristor Crossbars Based on Path Selection

Memristors have recently shown significant promise in designing memory and logic subsystems. A 2D-crossbar architecture built with memristor arrays provides a convenient platform for storing multivalued memory states by utilizing the analog variation of current-induced resistance through these cells. The integration of CMOS components with non-CMOS memristor cells further enhances the scope of their applications to various complex system designs. However, present-day memristors by virtue of their inherent structure are prone to various manufacturing defects and sensitive to operational modalities. Existing techniques for testing memristor arrays are either ad hoc in nature or suited for application-specific designs with little concern for optimizing test time. In this work, we envisage a 2-D memristor crossbar as a network and identify certain paths that are suitable for fault sensitization. For full-size square and rectangular memristive crossbars, the proposed method optimizes test time using a path-based technique guided by maximum matching in bipartite graphs. An integer linear programming (ILP) formulation is then used to solve the problem for a general crossbar, either full or incomplete. Simulation results with LTspice demonstrate the effectiveness and superiority of the method to the prior art in terms of test time and fault coverage.
Retuning the actuator proportional–integral–derivative controller of spinning missiles

The hinge moment acting on the actuator will cause an out-of-plane moment, which is a destabilizing factor to the angular motion of spinning missiles. A new tuning criterion for the actuator controller is proposed to decrease the out-of-plane moment. It is noted that the integral element does not decrease the out-of-plane moment. A carefully designed proportional–derivative controller with some compromises can ensure the stability of the missile and provide good performance for the actuator.