Miracle-dz/UniFAR-FTUs huggingface dataset:
University of Birmingham Economic evaluation of interventions in Parkinson's disease

Background: Parkinson’s disease (PD) management comprises of drug treatments, surgery and physical activity/occupational therapies to relieve PD’s symptoms. The aim of this study is twofold; firstly, to appraise recent economic evaluation studies on PD management in order to update the existing knowledge and, secondly, to facilitate decision making on PD management by assessing the cost-effectiveness of all types of PD interventions. Methods: A systematic search for studies published between 2010 and 2018 was conducted. The inclusion and exclusion of the articles were based on criteria relevant to Population, Intervention, Comparison, Outcomes and Study design (PICO). The reporting quality of the articles was assessed according to Consolidated Health Economic Evaluation Reporting Standards. Results: Twenty eight articles were included, 10 of which were evaluations of drug treatments, 10 deep brain stimulation (DBS) and 8 physical/occupational therapies. Among early-stage treatments, Ti Ji dominated all physical activity interventions, however, its cost-effectiveness should be further explored in relation to its duration, intensity, and frequency. Multidisciplinary interventions of joint medical and non-medical therapies provided slightly better health outcomes for the same costs. In advanced PD patients, adjunct drug treatments could become more cost-effective if introduced during early PD and, although DBS was more cost-effective than adjunct drug therapies, the results were time-bound. Conclusion: Conditionally, certain PD interventions are cost-effective. However, PD progression differs in each patient, thus the cost-effectiveness of individually-tailored combinations of interventions, which could provide more time in less severe disease states and improve patients’ and caregivers’ quality of life, should be further explored.
A PROSPECTIVE STUDY ON BAD OBSTETRIC HISTORY IN PREGNENET WOMEN

Pregnancy loss is a daunting and difficult problem for families and clinicians. Pregnancy loss is synonymous with responsibility, pain, and states of depression. For the mother, birth and death is a tragic event and of importance in clinical practise. The key purpose of this study is to determine the risk factors and outcome of births in Bad Obstetric History (BOH) cases and to separate the outcomes from the outcome of treatment. A prospective study from June 2019 to May 2020 was examined on 64 pregnancies having BOH (history of unexplained stillbirth / neonatal death, three or more consecutive abortions, etc.). There was a critical higher incidence of recurrent pregnancy loss (cervical incompetence), malpresentation, hypertension, APLA, preterm deliveries, overt diabetes mellitus, hypothyroidism, and caesarean section between groups (P<0.05). Only 34 (53.13%) women out of 64 in the BOH group recognized to have the possible factor responsible for pregnancy losses. In 30 (46.87%), no probable causes could be identified. 11 (17.19%) patients identified with more than one risk factor. The number of percentages of pregnancies with BOH, the positive result forum risk factors, were not established. The BOH party, however, displayed substantially more APLA, hypertension, malpresentation, cervical incompetence, LSCS, MSL, preterm deliveries, hypothyroidism, and caesarean section.
BIOINFORMATICS Family classiﬁcation without domain chaining

Motivation: Classiﬁcation of gene and protein sequences into homologous families, i.e. sets of sequences that share common ancestry, is an essential step in comparative genomic analyses. This is typically achieved by construction of a sequence homology network, followed by clustering to identify dense subgraphs corresponding to families. Accurate classiﬁcation of single domain families is now within reach due to major algorithmic advances in remote homology detection and graph clustering. However, classiﬁcation of multidomain families remains a signiﬁcant challenge. The presence of the same domain in sequences that do not share common ancestry introduces false edges in the homology network that link unrelated families and stymy clustering algorithms. Results: Here, we investigate a network-rewiring strategy designed to eliminate edges due to promiscuous domains. We show that this strategy can reduce noise in and restore structure to artiﬁcial networks with simulated noise, as well as to the yeast genome homology network. We further evaluate this approach on a hand-curated set of multidomain sequences in mouse and human, and demonstrate that classiﬁcation using the rewired network delivers dramatic improvement in Precision and Recall, compared with current methods. Families in our test set exhibit a broad range of domain architectures and sequence conservation, demonstrating that our method is ﬂexible, robust and suitable for high-throughput, automated processing of heterogeneous, genome-scale data.
DEPATHOLOGIZING AND EMANCIPATING CLINICAL PSYCHOLOGY IN THE CONTROVERSY OVER EDUCATIONAL ITINERARIES

current debate on plans of study in Clinical Psychology in and out of the scope of healthcare. A study plan is proposed for a Master’s degree in Clinical Psychology for professional practice outside of the health-care system, and opportunities and risks of the study plans for Internal Resident Psychologist (IRP) and General Health Psychologist (GHP) are also discussed.
IRE1 α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death during endoplasmic reticulum stress

When unfolded proteins accumulate to irremediably high levels within the endoplasmic reticulum (ER), intracellular signaling pathways called the unfolded protein response (UPR) become hyperactivated to cause programmed cell death. We discovered that thioredoxin-interacting protein (TXNIP) is a critical node in this “Terminal UPR. ” TXNIP becomes rapidly induced by IRE1 α , an ER bifunctional kinase/endoribonuclease (RNase). Hyperactivated IRE1 α increases TXNIP mRNA stability by reducing levels of a TXNIP destabilizing micro-RNA, miR-17. In turn, elevated TXNIP protein activates the NLRP3 inflammasome, causing Caspase-1 cleavage and interleukin 1 β (IL-1 β ) secretion. Txnip gene deletion reduces pancreatic β -cell death during ER stress, and suppresses diabetes caused by proinsulin misfolding in the Akita mouse. Finally, small molecule IRE1 α RNase inhibitors suppress TXNIP production to block IL-1 β secretion. In summary, the IRE1 α -TXNIP pathway is used in the terminal UPR to promote sterile inflammation and programmed cell death, and may be targeted to develop effective treatments for cell degenerative diseases.
Liquid Crystal-Based Biosensors

Prolific research toward the development and modification of biosensing platforms is expanding the horizon of clinical diagnosis, health monitoring and drug diagnosis. Most biosensors performance relies on sophisticated instrumental analysis, which is costly, time-consuming and involves additional complications and risks. Liquid crystal biosensors have been considered as an efficient alternative to conventional sensing methodologies. Due to the orientation-dependent interactions at their interface, they can be designed to detect specific biomolecular entities and prevent the need for sophisticated instrumental analysis. This review summarizes the studies on liquid crystalline materials for biosensing applications from molecular elaboration and design perspectives.
ASYMPTOTIC PROPERTIES OF SEVERAL ESTIMATORS OF THE

We deal with the estimation of the autocorrelation of a stationary Gaussian process with additive outliers. The biases of several estimators of the autocor relation based on limiter estimating functions are compared. We show the esti mator due to Sen[11]is the least biased, namely the most robust among them.
HEMATOPOIETIC STEM CELLS Xenograft models for normal and malignant stem cells Immunodeficient mice for studying normal and malignant human hematopoiesis

The model systems available for studying human hematopoiesis, malignant hema-topoiesis,andhematopoieticstemcell(HSC) function in vivo have improved dramati-callyoverthe lastdecade, primarily due to improvements in xenograft mouse strains. Severalrecentreviewshavefocusedonthe historic development of immunodeficient mice over the last 2 decades, as well as their use in understanding human HSC and leukemia stem cell (LSC) biology and function in the context of a humanized mouse. However,intheinterveningtimesincethese reviews, a number of new mouse models, technical approaches, and scientific ad-vanceshavebeenmade.Inthisreview,we update the reader on the newest and best models and approaches available for studying human malignant and normal HSCs in immunodeficient mice, including newly developed mice for use in chemotherapy testing and improved techniques for humanizing mice without laborious purification of HSC. We also review some relevantscientificfindingsfromxenograft studies and highlight the continued limi-tations that confront researchers working with human HSC and LSC in vivo. ( Blood . 2015;125(17):2630-2640)
OPTH_A_231804 3855..3869

1Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA; 2Retina Associates, Elmhurst, IL, USA Abstract: Subretinal gene therapy trials began with the discovery of RPE65 variants and their association with Leber congenital amaurosis. The RPE65 protein is critical for the normal functioning of the visual phototransduction cascade. RPE65 gene knockout animal models were developed and showed similar diseased phenotypes to their human counterparts. Proof of concept studies were carried out in these animal models using subretinal RPE65 gene replacement therapy, resulting in improvements in various visual function markers including electroretinograms, pupillary light responses, and object avoidance behaviors. Positive results in animal models led to Phase 1 human studies using adeno-associated viral vectors. Results in these initial human studies also showed positive impact on visual function and acceptable safety. A landmark Phase 3 study was then conducted by Spark Therapeutics using a dose of 1.5 x10 vector genomes after dose-escalation studies confirmed its efficacy and safety. Multi-luminance mobility testing was used to measure the primary efficacy endpoint due to its excellent reliability in detecting the progression of inherited retinal diseases. After the study met its primary endpoint, the Food and Drug Administration approved voretigene neparvovec (Luxturna) for use in RPE65-associated inherited retinal diseases.
Uniqueness of Solutions of the Initial-Value Problem for u sub t - delta phi(u) = 0.

Abstract : Equations of the form u sub t - delta phi(u) = 0 arise in mathematical models of many physical situations. The uniqueness of solutions of the associated initial-value problem in R superscript N is considered in this paper. It is shown that bounded weak solutions (i.e., solutions in the sense of distribution) which further satisfy an integrability condition are unique.
Theoretical decomposition of neuronal networks

An approach to the calculation of the unobservable elements of the hippocampal formation is presented. The approach is based on characterizing the transformational properties of this neuronal structure using the kernels of a functional power series expansion. In this approach the network properties are characterized as the composite of input/output functions measured for each subsystem in the network. The multidimensional Laplace transforms are then computed and manipulated to provide an estimate of the transformation properties of the unobservable elements. <<ETX>>
Communications of the Association for Information Systems

: Is the IS discipline a single discipline that focuses on both behavioral (BIS) and technical (TIS) topics, or is it two disciplines split between these orientations? Current opinion emphasizes BIS and reinforces the notion that researchers practice research in disconnected silos as opposed to a relatively continuous web. Such silos do disservice to the diversity of scholarly interests, skew productivity expectations in favor of small subsets of journals that often exclude technical-and decision science-oriented journals, and run the risk of creating self-perpetuating journal groupings. Silos disadvantage IS researchers by making the discipline narrower in comparison to other business disciplines and contradict the nature of IS pedagogy that equally reflects technology and management. We applied social network and cross-citation analyses to a sample of 98 IS journals to examine the cohesiveness of IS and to understand the extent to which boundary-spanning journals maintain scholarly connections between the approaches. Distinguishing between weak and strong ties among journals, we found that a discipline that comprises both BIS and TIS journals is highly cohesive in terms of weaker ties and that many boundary-spanning journals are quite balanced in their citations to and from each orientation. However, we did not find that IS is uniformly cohesive. Even so, our findings imply that IS scholars with different interests can parse out distinct subsets of journals that are central to their interests. We demonstrate as much by examining the most central journals for three examples of IS scholars: those with a strongly behavioral approach, with sociotechnical interests, and with specialized interests, such as medical informatics. The most central journals for these three interests are distinct subsets of the IS discipline.
Targeted Allele Replacement Mutagenesis of Corynebacterium pseudotuberculosis (cid:1) †

A two-step allele replacement mutagenesis procedure, using a conditionally replicating plasmid, was devel- oped to allow the creation of targeted, marker-free mutations in Corynebacterium pseudotuberculosis . The relationship between homologous sequence length and recombination frequency was determined, and en- hanced plasmid excision was observed due to the rolling-circle replication of the mutagenesis vector. Further-more, an antibiotic enrichment procedure was applied to improve the recovery of mutants. Subsequently, as proof of concept, a marker-free, cp40 -deﬁcient mutant of C. pseudotuberculosis was constructed. Corynebacterium pseudotuberculosis is a pathogen of multi-ple species (1–4, 7, 9–12, 14, 17, 19). To facilitate molecular studies of this organism, we report here an effective allele replacement mutagenesis procedure. A ca. 2.7-kb HpaI/StuI fragment containing the kanamycin resistance gene and 2 open reading frames not associated with plasmid replication (8) was excised from the Corynebacterium glutamicum temperature-sensitive (TS) vector,
Short-term effects of vitamin A and antimalarial treatment on erythropoiesis in severely anemic Zanzibari preschool children 1–3

Background: ThepathophysiologyofanemiaincoastalEastAfrica is complex. Impaired erythropoietin production is one possible mechanism. Plasmodium falciparum malaria has been found to blunt erythropoietin production, whereas vitamin A stimulates erythropoietin production in vitro. Objective: We investigated the 72-h effects of vitamin A and the antimalarial drug sulfadoxine pyramethamine (SP) on erythropoietin production in severely anemic (hemoglobin (cid:1) 70 g/L) preschool children in Zanzibar, a region of known vitamin A deficiency. We hypothesized that both treatments would stimulate erythropoietin production directly, within 72 h, before a change in hemoglobin would occur. Design: Onehundredforty-oneseverelyanemicchildrenwereiden-tified during the baseline assessment of a morbidity substudy of a community-based micronutrient supplementation trial. All severely anemic children were randomly assigned to receive either vitamin A (100 000 or 200 000 IU depending on age) or SP at baseline; 72 h later they received the opposite treatment plus daily hematinic syrup for 90 d. Erythropoietic and parasitic indicators were assessed at baseline and again after 72 h. Results: After72h,SPreducedthemalariaparasitedensity(by5029 parasites/ (cid:1) L; P (cid:2) 0.001), CRP concentrations (by 10.6 mg/L; P (cid:3) 0.001), and the proportion of children infected with malaria (by 32.4%; P (cid:2) 0.001). Vitamin A reduced CRP (by 9.6 mg/L; P (cid:3) 0.011), serum ferritin (by 18.1 (cid:1) g/L; P (cid:3) 0.042), and erythropoietin (by 194.7 mIU/mL; P (cid:3) 0.011) concentrations and increased the reticulocyte production index (by 0.40; P (cid:3) 0.041). Conclusions: Contrary to our hypothesis, vitamin A significantly decreased erythropoietin concentration. The most important effect of both vitamin A and SP was the rapid reduction of inflammation. Vitamin A also mobilized iron from stores and stimulated the production of new erythrocytes. Am J Clin Nutr 2005;82:406–12.
Online Learning Portal using NLP

:- This paper is devoted to use NLP techniques for Generating Narrative films from Text/PDF to evolve education in elementary and secondary schools as students get exhausted by usual text and are more enthusiastic towards videos . With the help of visual aids this would not only help them better remember the content being delivered but also improve their vocabulary. It also covers automatic question generation based on text analysis with the goal to develop an intelligent framework that should automate or semi-automate the process of quiz and exam question generation. The framework operation is predicated on information retrieval and NLP algorithms. It allows generating “Wh”-type (What? When? How? ) questions .
Kangasmerkkien tunnistus neuroverkkojen avulla

Augmented reality has risen to be a familiar topic in the 2010s. People see the possibilities in merging technology with reality. This is where image recognition and machine vision become essential parts of. The basic idea of the project was to create an application that an user can take a picture of a patch with and in return get information about the patch provider and their location. The application would, in this case, need some kind of image recognition section. To recognize an image, there have already been developed many different algorithms. The work ended up using a neural network that uses Alexnet’s derivative model. The idea was to estimate how the amount of images affects the neural network learning and, in general, how well neural networks serve to solving this kind of image recognition problem. The neural network aims at sorting images to desired classes. Cloth patches were used as a research material. The amount of research material was multiplied by rolling each patch to different angles compared to the original. The efficiency of the neural network was studied by creating five different versions, making changes to each of them in comparison to previous version. The changes included the number of training iterations and the amount of training material. The hypothesis was that the more training material there was for the neural network, the better it was guessing the class right. The results were handled by creating a table of different neural network versions and studying the neural network evolution between the same images. The evolution involving the amount of training images didn’t change much after 1000 training images. The percent of successful recognition stayed at about 95 % although 3000 training images were used. Clear differences were noticed in the effect of image color and color scheme. The shape of the patches had relatively small impact on recognition. Based on the study, it can be concluded that the above-mentioned image recognition method can fulfill the application's requirements for identifying patches with a reasonable number of images.
Collective oscillations of a one-dimensional trapped Bose-Einstein gas

Starting from the hydrodynamic equations of superfluids, we calculate the frequencies of the collective oscillations of a harmonically trapped Bose-Einstein gas for various one-dimensional configurations at zero temperature. These include the mean-field regime described by Gross-Pitaevskii theory and the beyond-mean-field regime at small densities described by the Lieb-Liniger theory. The relevant combinations of the physical parameters governing the transition between the different regimes as well as the conditions of applicability of the hydrodynamic equations are discussed.
Abstract PAEPSY 2021 Title : Meta-Analytic Structural Equation Models of Executive Functions and Math Intelligence in Preschool Children

BACKGROUND : Response inhibition, attention shifting, and working memory updating are the three core executive functions (EFs; Miyake et al., 2000) underlying other cognitive skills that are relevant for learning and everyday life. For example, they have shown to be differentially related to the mathematical component of intelligence (i.e., math intelligence) in school students and adults. While researchers suppose these three EFs to become more differentiated from early childhood to adulthood, neither the link of these constructs nor their structure has been conclusively established in preschool children yet. Primary studies on path models connecting EFs and math intelligence diverge in the exact relation of EFs and math intelligence. It remains unclear whether inhibition, shifting, and updating exhibit distinct but correlated constructs with respect to their relation to math intelligence. OBJECTIVES : With our meta-analysis, we aimed to (a) synthesize the relation between the three EFs and math intelligence in preschool children; and (b) compare plausible models of the effects of EFs on math intelligence. DISCUSSION Our findings corroborate the positive link between EFs and math intelligence in preschool children and are similar to other age groups. From the model testing, we learned that representing EFs by a latent variable, thus capturing the covariance among the three core EFs, explained substantially more variation in math intelligence than representing them as distinct constructs.
Role of Yava (Hordeum vulgare Linn.) as a Swastyahita Aahara Dravya

— Swasthya Rakshan i.e. maintaining well being of a person is the foremost aim of Ayurveda. It can be achieved by following Dincharya, Rituchrya mentioned in Ayurvedic samhitas. Now a day’s risk of lifestyle diseases like Diabetes mellitus, Obesity, Heart disease, Hypertension, Cancer etc. is increasing day by day. It is the commonest problem world population is facing right now. This is a result of unhealthy diet and lack of physical activity. To control these; healthy changes in lifestyle and food habits is the need of time. Yava (Hordeum vulgare Linn.) is herbal drug belonging to Gramineae/ Poaceae family mentioned as Swasthahita Dravya in Samhitas. It is also used as a dietary supplement specifically in Vasant, Varsha and Sharad Ritu. Yava is in possession of Kashay, Madhur Rasa, Katu Vipaka, Sheet Veerya and Ruksha Guna. It is mentioned as Lekhaniya Dravya. Yava which is also known as Barley is rich with essential nutrients like protein, dietary fiber and other micronutrients. It is having low amount of fat which is beneficial to decrease chances of lifestyle diseases. Use of Yava in daily diet would be beneficial to maintain good health. It is cost effective and easily available worldwide. This review shows the role of Yava in daily food habits for healthy life .
The use of a VOC Sensor to Measure Freshness of Fruits

— With North America having one of the larger food wastages by consumers, there is a need for a system that will bring awareness to the state of the food, to reduce food waste. Fruits have been known to release volatile organic compounds (VOC) throughout their lifecycle, a VOC measuring device has been applied to measure the freshness level. A banana, cocktail tomatoes and a yellow pepper were used as samples. Although a correlating trend between the samples could not be determined, the variance in measurement readings for each sample showed promising results.