Miracle-dz/UniFAR-FTUs huggingface dataset:
Age-related Distribution of Mycoplasma pneumoniae in Respiratory Tract Infection in a Developing Country

Mycoplasma pneumoniae is an organism that belongs to the family mycoplasmataceae. Its role as a disease causing agent continues to draw interest especially with the advent of highly sensitive detection techniques. This bacterium poses a health problem to both animals and humans resulting in serious illnesses such as community-acquired lung work investigated the prevalence of M. pneumoniae as agent of respiratory tract infections using culture and molecular methods of identification, in patients attending Pulmonary Tuberculosis as well as detecting the most virulence gene of this organism. A total of 263 sputum samples were collected: 188 test subjects and 75 control subjects. These samples were examined bacteriologically using PPLO broth and agar, MacConkey, blood and chocolate agars. The overall prevalence rates of M. pneumoniae among the 263 subjects were 4.9% by culture. The prevalence rate of the organism was significantly higher among the test subjects 11(5.9%) by culture than the control subjects 2(2.7%) by culture. The colonization of the organism was significant among the age groups 31-40 years (P<0.05). The antibiotic sensitivity pattern of M . pneumoniae showed that the organism was susceptible to Lyntriaxone, Levofloxacin, Ciprofloxacin, Azithromycin and Doxycycline while it showed resistance to Septrin, Peflacine, Rifampicin, Erythromycin and Norbactin. M. pneumoniae is an additional bacterium that might contribute to respiratory tract infections and consequently to death when it disseminates to various organs of the body, hence their presence in the respiratory tract of children, adolescent and adults should not be treated with levity.
Optimized Design of Hardware Monitors for Better Performance of Network Processors

— As the Internet becomes integrated into nearly all aspects of everyday life, its reliability grows in importance. This vital communication resource, which has become an inviting target for attackers, must be protected with the same vigor as the end-systems it interconnects. Recent trends in network router architecture towards programmability and flexibility have increased the susceptibility of communication hardware to software attacks which modify intended data processing and forwarding functions. Contemporary routers typically feature network processors, whose protocol processing functions are determined via software. Prior work has shown that these general-purpose software-based processing systems can be attacked with data packets sent through the Internet. As a defense mechanism, the correct functionality of a network processor can be verified by a hardware monitor that observes processor operation and compares it to expected behavior. In the event of an attack, the monitor can interrupt the network processor, suppress malicious behavior, and reset the processor to a usable state for processing of subsequent traffic. In this work, we present several significant advances in hardware monitoring for network processors. A low-overhead monitor architecture that evaluates correct network processor operation in real-time on an instruction-by-instruction basis is described and tested. The monitor is shown to effectively prevent stack smashing attacks on processors that use Harvard architecture, a widely used network processor configuration. Through experimentation, we show that our approach to hardware monitoring does not affect data plane packet throughput. In the event of an attack, malicious packets are dropped while packets of regular network traffic proceed through the network unaffected. A full evaluation of monitor architectural parameters is provided to create an optimized monitor design.
Accounting Students’ Motives, Expectations and Preparedness for Higher Education: A Study among University and College Students in Multan

the students Abstract: The students getting entered in colleges and universities for their higher education have some sort of motives and expectations towards their degree programs. They also have some degree of preparedness towards their educational institute and mainly towards their major subjects. The purpose of this paper is to investigate the differences in motivation, expectations and preparedness towards the higher education among first-year students on gender basis having accounting as a major subject. Data have been collected from the educational institutions of Multan. It is found that students either male or female, have same level of motives, expectations and preparedness towards higher education. The results of this study revealed no significance differences on the basis of gender among the first year students of college and university.
High Expression of the R-Type Voltage-Gated Ca 2 (cid:1) Channel and Its Involvement in Ca 2 (cid:1) -Dependent Gonadotropin-Releasing Hormone Release in GT1–7 Cells

The GT1 cell has been widely used as a model cell to study cellular functions of GnRH neurons. Despite the importance of Ca 2 (cid:1) channels, little is known except for L- and T-type Ca 2 (cid:1) channels in GT1 cells. Therefore, we studied the diversity of voltage-gated Ca 2 (cid:1) channels in GT1–7 cells with perforated- patch clamp and RT-PCR. An R-type Ca 2 (cid:1) channel blocker, SNX-482, inhibited the Ca 2 (cid:1) currents by 75.6% in all cells ex- amined (n (cid:2) 9). A T-type Ca 2 (cid:1) channel blocker, Ni 2 (cid:1) , inhibited the Ca 2 (cid:1) currents by 12.6% in all cells examined (n (cid:2) 9). An L-type Ca 2 (cid:1) channel blocker, nimodipine, inhibited the Ca 2 (cid:1) currentsby17.9%infiveof11cellsexamined.WhenusingBa 2 (cid:1) as a charge carrier, another dihydropyridine antagonist, ni- fedipine, clearly inhibited the currents by 12.1% in all cells examined (n (cid:2) 16). An N-type Ca 2 (cid:1) channel blocker, (cid:3) -cono-toxin-GVIA, inhibited the Ca 2 (cid:1) currents by 13.8% in three of 20 cells examined. A P/Q type Ca 2 (cid:1) channel blocker, (cid:3) -agatoxin-IVA, had no effect on the currents (n (cid:2) 9). RT-PCR revealed that GT1–7 cells expressed the (cid:4) 1B , (cid:4) 1D , (cid:4) 1E , and (cid:4) 1H subunit mRNA. Furthermore, SNX-482 and nifedipine inhibited the high K (cid:1) -induced increase in the intracellular Ca 2 (cid:1) concentration and GnRH release. (cid:3) -Conotoxin-GVIA and (cid:3) -agatoxin- IVA had no effect. These results suggest that GT1–7 cells express R-, L-, N-, and T-type voltage-gated Ca 2 (cid:1) channels; the R-type was a major current component, and the L-, N-, and T-types were minor ones. The R- and L-type Ca 2 (cid:1) channels play a critical role in the regulation of Ca 2 (cid:1) -dependent GnRH release. ( Endocrinology 145: 2375–2383, 2004)
Altered Na/Ca exchange distribution and activity in ventricular myocytes from failing hearts.

In mammalian cardiac ventricular myocytes, Ca efflux via Na/Ca exchange (NCX) occurs predominantly at t- 50 tubules. Heart failure is associated with disrupted t-tubule structure, but its effect on t-tubule function is 51 less clear. We therefore investigated t-tubular NCX activity in ventricular myocytes isolated from rat hearts 52 ~18 weeks after coronary artery ligation (CAL) or corresponding Sham operation. NCX current (I NCX ) and L- 53 type Ca current (I Ca ) were recorded using the whole-cell voltage-clamp technique in intact and detubulated 54 (DT) myocytes; intracellular ([Ca] i ) was monitored simultaneously using fluo-4. I NCX was activated and 55 measured during application of caffeine to release Ca from sarcoplasmic reticulum (SR). Whole-cell I NCX was 56 not significantly different in Sham and CAL myocytes, and occurred predominantly in the t-tubules in Sham 57 myocytes. CAL was associated with redistribution of I NCX and I Ca away from the t-tubules to the cell surface, 58 and an increase in t-tubular I NCX /I Ca density from 0.12 in Sham to 0.30 in CAL myocytes. The decrease in t- 59 tubular I NCX in CAL myocytes was accompanied by an increase in the fraction of Ca sequestered by SR. 60 However, SR Ca content was not significantly different in Sham, Sham DT and CAL myocytes, but was 61 significantly increased by DT of CAL myocytes. In Sham myocytes there was hysteresis between I NCX and 62 [Ca] i , which was absent in DT Sham, but present in CAL and DT CAL, myocytes. These data suggest altered 63 distribution of NCX in CAL myocytes.
Calcul de développements de Puiseux et application au calcul du groupe de monodromie d'une courbe algébrique plane

Dans cette these, nous presentons un nouvel algorithme symbolique-numerique pour calculer une approximation numerique des developpements de Puiseux au-dessus des points critiques, que nous utilisons pour calculer le groupe de monodromie d'une courbe algebrique plane. Essentiellement, l'algorithme de calcul de developpements de Puiseux utilise des calculs modulo un nombre premier p bien choisi pour obtenir des informations exactes sur les series de Puiseux. Ensuite, nous decrivons comment calculer une approximation numerique de ces series de Puiseux a partir de ces informations exactes. Nous etudions egalement la complexite de la partie symbolique de notre algorithme. Enfin, nous proposons un algorithme symbolique-numerique pour calculer le groupe de monodromie d'une courbe algebrique plane qui utilise ces developpements de Puiseux.
Willmore-type regularization of mean curvature flow in the presence of a non-convex anisotropy. The graph setting: analysis of the stationary case and numerics for the evolution problem

In this paper we investigate the motion of one dimensional graphs under anisotropic non-convex mean curvature flow regularized via a Willmore term. Aiming at understanding the evolution problem when we let the regularization parameter tend to zero, we first present rigorous analytical results for the stationary case. Subsequently we discuss the time dependent problem focussing mainly on numerical simulations. We discretize by finite elements,provide a semi implicit scheme and a number of numerical experiments. MSC2010: 35G31, 65M60, 35Q99.
Rest and Active Arm Movement Classification Based on Subthalamic Nucleus LFPs for Parkinson’s Disease Subtypes

​ — Adaptive deep brain stimulation (DBS) is expected to improve Parkinson’s disease (PD) symptoms. This advance in neurostimulation strategy requires to interact with pathological electrical signaling from basal ganglia circuitry and to use this continuous feedback for controlling therapeutic DBS. Further knowledge about how such signals change in terms of clinical phenotypes and rest/movement states is necessary to optimize this adaptive method and to bridge the clinical needs with daily activities. This work assessed the differences in local field potentials (LFP) spectrum recorded from the subthalamic nucleus (STN) in rest and active arm movement and classified these conditions for the different PD clinical subtypes seeking to estimate the cost underlying the early movement detection. Our results suggest there is a tradeoff between the signal length and accuracy, in which the subtypes play an important role in this performance. These findings may define a crucial design variable for real-time applications and allow future perspectives for tailored DBS design.
OEPARTEMENT TOEGEPASTE ECONOMISCHE WETENSCHAPPEN

In four experiments, we examined the impact of the nature and consistency of people's social value orientations on the emergence of cooperative behavior in conditions of neutral, morality or might priming. In line with Van Lange (2000), we expected social value orientations to have a greater impact in ambiguous (neutral priming) than in unambiguous (morality and might priming) situations. We also expected the later moderation to be higher among participants low in consistency (see also Hertel and Fiedler, 1998). Overall, participants' behavior shifted in prime-consistent ways. However, cooperation was reduced among high consistent pro-selfs primed with morality concepts. Experiments 2-4 replicate and generalize these findings, and reveal that high consistent pro-selfs exploited partners believed to be cooperative as a result of morality priming. Implications of these results are discussed in the wider context of interdependence theory, and in the context of automatic behavior effects. high consistent pro-socials and low consistent individuals cooperated more in the morality priming condition than in the neutral priming condition, eM = 2.96 vs. M = 2.06), . E(l,174) = 20.95,! < . 0001. A second planned comparison revealed that high consistent pro-socials and low consistent individuals cooperated less in the might priming condition than in the neutral priming condition, (M = 1.10 vs. M = 2.06), . E(l,174) = 22.74,! < . 0001. These results provide unambiguous
2011 International Conference on Energy and Electrical Systems (ICEES 2011)

This paper proposes new guaranteed convergence based particle swarm optimization (GCPSO) algorithm for solving optimal power flows with security constraints(line flows and bus voltages). This algorithm deals with the situation of non convergence due to very small velocities that occur in a variant inertia weight based PSO [1]. By using a new updating formula based on number of successes and failures, this new guaranteed convergence based PSO has been developed. Basically, this algorithm follows the same principle of PSO, but the new updation will take place when the velocities become very smaller. In this paper, Variable constriction factor has been considered for GCPSO. The OPF problem has been considered with Quadratic cost function to realize Optimal Power Flow using GCPSO applied to IEEE 30 and IEEE 14 bus systems. Simulation results show that proposed approaches gives better solution than earlier reported approaches with guaranteed convergence with little sacrifice of speed.
A MULTICENTRIC, DOUBLE BLIND, RANDOMIZED, ACTIVE CONTROL, PARALLEL GROUP, COMPARATIVE STUDY TO EVALUATE THE EFFICACY, SAFETY AND TOLERABILITY OF REBAMIPIDE OPHTHALMIC SUSPENSION 2.0% W/V VS. SODIUM HYALURONATE OPHTHALMIC SOLUTION 0.1% W/V FOR THE TREATMENT OF PATIENTS WITH DRY EYE

Background: The present study was designed to evaluate the efficacy, safety and tolerability of Rebamipide Ophthalmic Suspension 2.0% w/v (Arm A) Vs. Sodium Hyaluronate Ophthalmic Solution 0.1% w/v (Arm B) in patients suffering from Dry Eye. The main objective of the study was to compare patient-perceived relief from the symptoms of foreign body sensation, dryness, photophobia, eye pain, blurred vision. Method: It was a comparative, randomized, double blind, parallel group, active control, multi-centric clinical trial conducted in 8 centers across India in patients with signs and symptoms of dry eye. The recruitment has been start from Jun 09, 2015 to Mar 16, 2016. Total 236 patients (aged 18 – 65 years) were randomized in the ratio of 1:1 in both arms. All the patients were advised to instil one drop four times daily in affected eye of either Rebamipide Ophthalmic Suspension 2.0% w/v or Sodium Hyaluronate Ophthalmic Solution 0.1 % w/v as per randomization. The treatment continued for 168 days with periodic follow-up on 28 th , 56 th , 84 th , 112 th , 140 th and 168 th days from start of treatment. Results: The current study showed the Mean change in Fluorescein Corneal staining score from baseline to visit 7 for Rebamipide Ophthalmic Suspension 2.0% w/v and Sodium Hyaluronate Ophthalmic Solution 0.1% w/v as – 2.15 and – 1.9 respectively. There were 15 clinical adverse events reported (Rebamipide: 06, Sodium Hyaluronate: 09) in the study and which were mild and transient in nature. Conclusion: Rebamipide Ophthalmic Suspension 2.0% w/v has higher efficacy of improving clinical features of dry eye when compared with Sodium Hyaluronate Ophthalmic Solution 0.1% w/v and as safe as Sodium Hyaluronate Ophthalmic Solution 0.1% w/v.
Janus Emulsions of Bertholletia Excelsa Oil and Silicone Oil

Janus emulsions of Bertholletia Excelsa oil and silicone oil in water were prepared in batch by high energy emulsification and their destabilization studied by observing the creaming and final separation of the two oils. The creaming was shown to be characteristic of a flocculated emulsion in accordance with the optical microscope image of a concentrated emulsion, but with few drop-drop contacts. During the creaming process the Janus drops suffered coalescence, but retained the Janus topology till the final stage after more than a month of storage, at which time the two oils set off separation into two bulk liquids. The unexpected stability of the topology per se indicated a more general importance of Janus emulsions than hitherto recognized and prompted a calculation to compare the relative free energy reduction during the coalescence versus the increase during the separation of the two oils. The latter energy change was significantly superior and was concluded to be an essential factor for the stability of the Janus topology. investigation into the fundamentals of preparing Janus emulsions from a selected Brazilian vegetable oil combined with a silicone. The results indicate a more wide spread importance of Janus emulsions and with this contribution we introduce the basic conditions for such an emulsion, built on a silicone oil and the vegetable oil from Bertholletia Excelsa.
RMHP_A_286488 2875..2885

1Department of Medical Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Comprehensive Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 3Department of Surgical Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia Introduction: Healthcare professionals continue to be at risk of acquiring occupationrelated hepatitis B virus infection because of noncompliance for the 3-dose primary series of hepatitis B vaccine recommended. The objective of the study was to determine the rate of and to identify the predictors of hepatitis B vaccination uptake in healthcare professionals in Ethiopia. Methods: A multicenter cross-sectional survey was conducted between May 19 2018 and June 15 2018. A stratified with systematic random sampling technique was used to select 260 healthcare professionals. A structured questionnaire was used to collect all the necessary primary data from samples. This survey analyzed hepatitis B vaccination uptake as the binary outcome variable (“noncomplete” vs “complete”) with regard to the 30 potential predictor variables. Both descriptive and inferential statistical analysis techniques have been used to address the study objective. Results: The rate of complete vs noncomplete hepatitis B vaccination uptake was 37.7% vs 62.3%. The significantly independent predictors of hepatitis B vaccination uptake were professional qualification (P=0.004), professional experience (P=0.013), household income (P=0.006), workload status (P=0.015), routine infant immunization program existence at the workplace (P=0.014), perceived susceptibility to infection (P=0.005), perceived safety of vaccine (P=0.001), prior occupational exposure to blood (P=0.006), training on universal precautions (P=0.015), and colleagues’ suggestion (P=0.002). Conclusion: The rate of hepatitis B vaccination uptake found was currently low. The significantly independent predictors of hepatitis B vaccination uptake included perceived safety, colleagues’ suggestion, professional qualification, perceived susceptibility, household income, prior occupational exposure to blood, professional experience, existence of routine infant immunization program at the workplace facility, workload status, and universal precautions training.
RNF12 catalyzes BRF1 ubiquitination and regulates RNA polymerase III-dependent transcription

RNA polymerase III (Pol III) is responsible for the production of small non-coding RNA species, including tRNAs and 5S rRNA. Pol III-dependent transcription is generally enhanced in transformed cells and tumors, but the underlying mechanisms remain not well understood. It has been demonstrated that the BRF1 subunit of TFIIIB is essential for the accurate initiation of Pol III-dependent transcription. However, it is not known whether BRF1 undergoes ubiquitin modification and whether BRF1 ubiquitination regulates Pol III-dependent transcription. Here, we show that RNF12, a RING domain-containing ubiquitin E3 ligase, physically interacts with BRF1. Via direct interaction, RNF12 catalyzes Lys 27 and Lys 33 -linked polyubiquitination of BRF1. Furthermore, RNF12 is able to negatively regulate Pol III-dependent transcription and cell proliferation via BRF1. These findings uncover a novel mechanism for the regulation of BRF1 and reveal RNF12
Development of a New Experimental Model for Investigating Osseointegration of Titanium Mini-Screws Placed Intraorally

A novel in-vivo pilot study was developed using the rabbit mandibular diastema to evaluate the effect of implant microand nano-surface topography on the rate of osseointegration. Six rabbits received one titanium mini-screw from both topographies in each diastema. Two rabbits were euthanized at 6, 22 and 85d post-implantation. Harvested mandibles were measured and processed for reverse torque, microCT, SEM and histological analyses. At 22 days, the nanosurface screws had higher mean torque values but both topographies reached nearly identical mean values after 85 days. Localized areas of crestal bone resorption were seen around all screw heads at 22 days. Sub-periosteal bone formation lateral to the screw heads led to complete coverage of the screws at 85 days. The epithelium of the overlying mucosa was parakeratinized stratified squamous. This intra-oral animal model is suitable to study osseointegration.
NSS_A_316997 1383..1393

1Department of Psychology, University of Fribourg, Fribourg, Switzerland; 2Center of Competence Sleep & Health Zurich, University of Zurich, Zurich, Switzerland Purpose: Sleep, in particular slow-wave sleep, is beneficial for memory consolidation. In two recent studies, a hypnotic suggestion to sleep more deeply increased the amount of slowwave sleep in both a nap and a night design. In spite of these increases in slow-wave sleep, no beneficial effect on declarative memory consolidation was found. As coupling of slowwaves and sleep spindles is assumed to be critical for declarative memory consolidation during sleep, we hypothesized that the missing memory benefit after increased SWS could be related to a decrease in slow-wave/spindle coupling. Participants and Methods: Data from 33 highly hypnotizable subjects were retrieved from a nap (n = 14) and a night (n = 19) study with a similar design and procedure. After an adaptation session, subjects slept in the sleep laboratory for two experimental sessions with polysomnography. Prior to sleep, a paired-associate learning task was conducted. Next, subjects either listened to a hypnotic suggestion to sleep more deeply or to a control text in a randomized order according to a within-subject design. After sleep, subjects performed the recall of the memory task. Here, we conducted a fine-grained analysis of the sleep data on slow-waves, spindles and their coupling. Results: In line with our hypothesis, listening to a hypnosis tape decreased the percentage of spindles coupled to slow-waves. Slow-wave parameters were consistently increased, but sleep spindles remained unaffected by the hypnotic suggestion. Conclusion: Our results suggest that selectively enhancing slow-waves without affecting sleep spindles might not be sufficient to improve memory consolidation during sleep.