Miracle-dz/UniFAR-FTUs huggingface dataset:
Adoption of building information modeling in developing countries: a phenomenological perspective

ADOPTION OF BUILDING INFORMATION MODELING IN DEVELOPING COUNTRIES A PHENOMENOLOGICAL PERSPECTIVE Building Information Modeling (BIM) is a cutting edge technology that has addressed prominent challenges in the Architecture, Engineering and Construction (AEC) industries in most of the developed countries. Construction industries in developing countries due to ide ntified challenges and unavailability of the clear understanding of best practices , are dithering whether to adopt this technology. The scope of this study was how to facilitate BIM adoption in developing countries. A phenomenological design approach was considered to seek early adopters’ and B IM professionals’ lived experiences on similar situations and how did they triumph over the hindrances against BIM adoption and made its implementation successful. A total of six participants with extensive BIM experience and first hand BIM appl ication knowledge were interviewed. The result confirms BIM adoption issues similariti es in both developed and developing countries. Recommended best practices for new BIM users in fou categories of education requirement, infrastructure requirement, sound pract ices, and working with partners with no previous BIM experience is represented in chapter five. The study limitation was the inability to reach out BIM professionals in develop ing countries therefore, considering the sim ilarities of BIM adoption issues, five of the participants selected for this study were from the United States whereas one participan t was selected from developing countries. The study concludes with recommendation for further study in thi s f eld.
Liraglutide Alleviates Diabetic Atherosclerosis through Regulating Calcification of Vascular Smooth Muscle Cells

Background Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia, which can induce the development of atherosclerosis (AS). Calcification of vascular smooth muscle cells (VSMCs) exerts an important role in the process of AS. In this study, the effects of liraglutide (LIRA) on VSMC under high-glucose condition and its mechanism were explored. Method After VSMC was treated by high glucose with or without LIRA in vitro, the alkaline phosphatase (ALP) activity was measured by the detection kit, osteogenic marker protein expression was detected by Western blotting, and calcification was determined by alizarin red staining. Subsequently, the DM rat model was established and the ALP activity, calcification, and osteogenic marker proteins were determined in vivo. Immunohistochemical (IHC) staining and hematoxylin-eosin staining were performed on the thoracic aorta of DM rats. Result The positive rate of SMα-actin expression in the DM + AS group was significantly lower than that in control rats, but LIRA administration increased the positive rate in the model. The expression of Cbfα-1 and OPN in the DM + AS group was significantly higher than that in the control group, while it was decreased after treatment of LIRA. The ALP activity and calcium content were increased in DM + AS rats, and the treatment of LIRA decreased the phenotypes in the rats, so as to delay the progression of AS in DM rats. Meanwhile, LIRA inhibited the ALP activity, upregulated SM-α expression, and downregulated expression of OPN and Cbfα-1 in VSMC under high-glucose (HG) conditions. Mechanically, HG-enhanced ALP activity, AKT, and ERK phosphorylation were inhibited by LIRA, PI3K antagonist LY294002, or ERK1/2 antagonist PD98059, in which cotreatment of LIRA with LY294002 and PD98059 could further enhance the effect of LIRA on VSMC, and GLP-1R antagonists reversed the phenotypes in the model. LIRA blocked the osteogenic transformation of VSMC through PI3K and ERK1/2 signaling pathways, which can be reversed by GLP-1R antagonists. Conclusion LIRA inhibited the abnormalities in VSMC calcification mediated by the GLP-1R, which was related to PI3K/Akt and ERK1/2 MAPK pathways. Therefore, the prospect and significance of LIRA in the treatment of DM complicated with AS were clarified.
Wind shear estimation and wake detection by rotor loads — First wind tunnel verification

The paper describes a simple method for detecting presence and location of a wake affecting a downstream wind turbine operating in a wind power plant. First, the local wind speed and shear experienced by the wind turbine are estimated by the use of rotor loads and other standard wind turbine response data. Then, a simple wake deficit model is used to determine the lateral position of the wake with respect to the affected rotor. The method is verified in a boundary layer wind tunnel using two instrumented scaled wind turbine models, demonstrating its effectiveness.
Nano Silver-Induced Toxicity and Associated Mechanisms

Abstract Nano silver is one of the most widely used engineering nanomaterials with antimicrobial activity against bacteria, fungi, and viruses. However, the widespread application of nano silver preparations in daily life raises concerns about public health. Although several review articles have described the toxicity of nano silver to specific major organs, an updated comprehensive review that clearly and systematically outlines the harmful effects of nano silver is lacking. This review begins with the routes of exposure to nano silver and its distribution in vivo. The toxic reactions are then discussed on three levels, from the organ to the cellular and subcellular levels. This review also provides new insights on adjusting the toxicity of nano silver by changing their size and surface functionalization and their combination with other materials to form a composite formulation. Finally, future development, challenges, and research directions are discussed.
FEMINISM AND THE ETHICS OF CARE

: Since the late 1970’s an important conversation concerning The Ethics of Care started becoming more and more prominent. Ethics of care is a feminist approach to ethics. One of the most prominent and influential key figures of this ethical theory was Carol Gilligan. According to her, traditional moral theories are male centric and problematic. They underestimate values that are culturally associated with women or their roles as females. In Ethics of care, vulnerability, care and relationality are privileged concepts. Ethics of care has been influential in certain areas such as medicines, nursing, education and has changed the perception of changed the perception of moral development.
Xiaoyao-Qingluoyin Cure Adjuvant-Induced Arthritis by Easing LPS Response-Related Pathway-Mediated Immune Abnormality

Qingluoyin (QLY) is a representative herbal formula prescribed for hot symptom-related rheumatoid arthritis treatment. Among its derivatives, Xiaoyao-Qingluoyin (XYQLY) attracts increasing attention due to the notable clinical efficacy. In this study, we compared its effects with QLY on adjuvant-induced arthritis (AIA) in rats and partially elucidated the antirheumatic mechanism using a network pharmacology-based strategy. After continuous oral treatments, clinical outcomes were systematically evaluated by radiographic, histological, immunohistochemical, and serological analyses. Possibly altered pathways were predicted based on reported interactions between the related chemicals and proteins/genes. The obtained conclusion was further validated by experiments in vitro. QLY and XYQLY eased polyarthritis in AIA rats after repeated doses, which reflected in reduced inflammation and bone degradation and downregulated p-p65, MMP3, and TLR4 expressions in joints. Meanwhile, they restored oxidative stress (MDA, SOD, GSH, T-AOC, and NO) and inflammatory indicators (TNF-α and CO) in serum. Synovium-based immunoblotting assay revealed that QLY and XYQLY were similarly effective in downregulating MMP3 and COX-2, but XYQLY treatment exhibited notable merit in suppressing p-p65 expression. Network pharmacology analysis hinted that XYQLY should exert greater impacts on LPS signaling and the downstream. Based on results from LC-MS analysis, we treated AIA rat-derived peripheral blood mononuclear cells with either QLY or XYQLY-based chemical combinations and confirmed that XYQLY had the better potential in inhibiting TLR4/NF-κB-controlled IL-6 production. Consequently, it led to a more profound decrease in Th17 cells counts. Overall evidence demonstrated that XYQLY was especially effective in regulating innate immunity and, therefore, improved immune environment in AIA rats as a whole.
Relationship between Serum Iron Level and Zinc Level with Attention Deficit Hyperactivity Disorder in Children

Background: ADHD (Attention Deficit/Hyperactivity Disorder) is the most frequent pediatric mental disorder. Zinc and iron are the most commonly investigated elements in children with ADHD. Objective: The aim of the current work was to discuss the role of iron and zinc in the brain development and the possible lowered serum levels of these elements in patients with ADHD to prevent and control some of ADHD symptoms. Patients and Methods : 42 children, aged from 4 to 14 years were included in this study as their parents complained from inattention, excess activity, or difficulties in school achievement of their children. All children included in the study were subjected to Full detailed medical history, clinical examination including physical examination, neurological examination, and laboratory investigations. Results: There was statistical significance decrease in both Fe and Zn among cases compare to control group. In addition, there were statistical significance increases in frequency of low Fe and Zn level among cases group compared to control group. The levels of Fe and Zn had statistically significant –ve relationships with the ratings given by both parents and teachers. A statistically significant link between Zn and Fe levels was also found. There were statistical significance increase in frequency of ADHD C and PH and sever ADHD among cases had low Zn level compare to cases had normal level. Conclusion: It could be concluded that both zinc and iron serum levels were found to have a significant correlation with parent-reported hyperactivity symptoms, suggesting that patients with low levels of iron and zinc may be at greater risk of developing ADHD symptoms.
The Role of Radioprotector Agents in the Protection of Normal tissue

The role of radioprotectors to reduce the cellular damage induced by ionizing radiation has been studied in human, animal and in vitro culture models. Radiation therapy cannot eradicate tumors successfully because of soft tissue damage. Proper use of radioprotective agents (before or shortly after radiation) can reduce normal tissue radiation toxicity and improve treatment output. There are three groups of radioprotectors: Synthetic protectors, antioxidant nutrients, and Immunomodulators. We discussed the radioprotective efficacy and its interaction against toxic agents. In addition, we discussed articles that have used radioprotective agents in the treatment of cancer with radiotherapy to protect normal tissue.
The Separation Power of Highly Porous 3D Nanofiber Sponges.

Sponges formed by the self-assembly of nanofiber building blocks are versatile materials used in various fields such as filtration, thermal insulation, scaffolding or sound absorption. Their potential seems to be constantly expanding given the variety of possible fiber materials, from bio-based to fossil polymers to inorganic nanofibers. In general, nanofiber sponges - also called nanofiber aerogels - are flexible, have low density, and a large specific surface area thanks to their tunable open-porous nanofiber based architecture. The latter property makes nanofiber sponges an interesting material for separation problems, as recently demonstrated for a variety of mixtures such as aerosols, emulsions, dispersions, solutions or two-phase systems. Due to their highly porous structure, they generally exhibit high filtration efficiency, flow rate and capacity. This article reviews the state of the art in the application of 3D nanofiber sponges for the different classes of mixtures. We will discuss on a mechanistic basis why nanofiber sponges are particularly well suited for separation applications. Finally, their performance in terms of efficiency, flow rate, capacity and regeneration will be compared to other fiber-based filter media.
The Effect of Feeding Herbal Extracts on the Growth and Molting of Mud Crabs (Scylla olivacea); Study of the Frequency of Herbal Extract Administration

Sudirman Kanna, Rumia, Erlina Subekti,Zainal Usman, Abbas, Yushinta 2021. The Effect of Feeding Herbal Extracts on the Growth and Molting of Mud Crabs ( Scylla olivacea ): Study of the Frequency of Herbal Extract Administration. Aquacultura Indonesiana. 22(2): 10-18. The quality of soft-shell crabs is influenced by the cultivation method, especially the molting stimulation method used. The aims of this study was to investigate the effect of feeding enriched with herbal extracts in inducing growth and molting of mud crabs in relation to the development of animal-friendly molting stimulation methods. The herbal extract (Vitomolt®) used was a combination of mulberry leaf extract (Morus alba) , Temulawak ( Curcuma xanthorrhiza) , and Temukunci ( Boesenbergia rotunda) fermented with Lactobacillus casei . There were 6o crabs weighing 100 g – 110 g and carapace width 7.1 cm – 7.7 cm were used in this study. The study consisted of five treatments of feeding frequency with vitomolt (FV), namely: feeding without Vitomolt (NV) or control (A), one day of FV administration per weeks (B), 2 days of PV administration per weeks (C), 3 days of FV administration per weeks (D) and 4 days of FV administration per weeks (E). The dose of herbal extract in the feed is 100 mL per kg of feed (trash fish). The results showed that the frequency of FV administration had an effect on absolute growth (P<0.05) and specific growth rate (P<0.05). Although the ANOVA showed that the frequency of FV administration had no significant effect for molting, but molting only occurred in crabs with PV treatment, while in the control there was no molting. The best frequency of administration is between 2 and 3 days of FV feeding per week. The results of this study illustrate that the use of herbal extracts can be used as an alternative method to stimulate growth and molting in soft-shell crab cultivation that is friendly to the environment and animals (animal welfare).
Representations of facial expressions since Darwin

Abstract Abstract Darwin's book on expressions of emotion was one of the first publications to include photographs (Darwin, The expression of the emotions in Man and animals, 1872). The inclusion of expression photographs meant that readers could form their own opinions and could, like Darwin, survey others for their interpretations. As such, the images provided an evidence base and an ‘open source’. Since Darwin, increases in the representativeness and realism of emotional expressions have come from the use of composite images, colour, multiple views and dynamic displays. Research on understanding emotional expressions has been aided by the use of computer graphics to interpolate parametrically between different expressions and to extrapolate exaggerations. This review tracks the developments in how emotions are illustrated and studied and considers where to go next.
ELT and Social Justice in Multilingual Classrooms

The challenge for educators and policy-makers is to ensure that the rights of all school children are respected, and the cultural, linguistic and economic resources of the nation are maximized. Today this is all the more relevant because many languages are becoming endangered and some have actually disappeared from the Indian linguistic landscape despite our claims to multilingualism and maintenance. The loss of a language is equivalent to the loss of an entire culture in itself. The first task of the school becomes relating home language to second language. In this manner more languages can be integrated and there is a movement towards other languages without losing the first and English is not contextualized in a western ambience but is taught through a contextually rich local perspective.
Groundwater Quality for Irrigation Purposes and Classification for Hydrochemical Facies in Parts of Southern Ijaw Local Government Area, Bayelsa State, Nigeria

As a result of economic development and rapid growth of the population in Southern Ijaw Local Government Area of Bayelsa State, Nigeria, there have been clear changes in the use of land, resulting in increased demand for water for various uses including agricultural activities. This study examined groundwater quality and classification of hydrochemical facies of communities in the study area. Fifteen (15) communities within the LGA were selected and groundwater from hand-dug well (HDW-15 samples) and borehole (BH-15 samples) was sourced during the wet season (July) and dry season (March) and analyzed for seasonal variation, irrigation purposes and hydrochemical facies classification using a standard method. Based on Sodium Adsorption Ratio (SAR) classification scheme, all groundwater sources in the area are excellent for irrigation purposes because they all have SAR values <3. This implies that SAR values of <3 will not threaten vegetation. The value of sodium percentage (Na%) ranges from 29.81% to 66.13% and 23.30% to 71.89% for hand dug wells in both wet and dry seasons. Similarly, the value of Na% ranged from 3.57% to 16.32% and 3.38% to 19.60% for borehole water in both wet and dry seasons. The groundwater hydrochemistry facies analysis indicated that there was an adjustment in groundwater chemistry during dry season while
pH-Dependence of Manganese (II) Oxidation Reaction by Novel Wild-Type and Mutants Recombinant <i>Phlebia radiata</i> Manganese Peroxidase 3 (rPr-MnP3) Enzymes

The goal of this study was to determine whether mutation of the Mn-binding site of wild-type recombinant Phlebia radiata manganese peroxidase 3 affected the pH-dependence kinetic parameters. pH range investigated was 2.5 – 12.0. The catalytic efficiency of the mutant enzymes at high and low pH in comparison to the wild-type was investigated using standard rPr-MnP3 protocol. Wild-type recombinant Phlebia radiata MnP3 enzyme showed optimal activity with Mn (II) as substrate at pH 5.0 and remained moderately active (approximately 40%) in the pH range of 6.0 - 9.0. The rPr-MnP3 mutants’ maximum activity ranged between 5.5 and 8.0. Wild-type and mutants rPr-MnP3 enzymes exhibited a similar pH profile with optimum pH of 3.0 for ABTS oxidation. Mutation has severely decreased the catalytic efficiency for Mn (II) oxidation at pH 5.0. The rPr-MnP3 enzymes showed enhanced affinity for Mn (II) at alkaline pH and a more alkaline range for catalysis than ever reported for any Manganese Peroxidase. This study reveals that at higher pH, rPr-MnP3 can function with alternative ligands in the Mn (II) site and does not have an absolutely obligate requirement for an all carboxylate ligand set. These results further strongly confirm that Mn 2+ binding site is the only productive catalytic site for Mn (II) oxidation.
Accessibility and Openness to Diabetes Management Support With Mobile Phones: Survey Study of People With Type 1 Diabetes Using Advanced Diabetes Technologies

Background Little is known about the feasibility of mobile health (mHealth) support among people with type 1 diabetes (T1D) using advanced diabetes technologies including continuous glucose monitoring (CGM) systems and hybrid closed-loop insulin pumps (HCLs). Objective This study aims to evaluate patient access and openness to receiving mHealth diabetes support in people with T1D using CGM systems or HCLs. Methods We conducted a cross-sectional survey among patients with T1D using CGM systems or HCLs managed in an academic medical center. Participants reported information regarding their mobile device use; cellular call, SMS text message, or internet connectivity; and openness to various channels of mHealth communication (smartphone apps, SMS text messages, and interactive voice response [IVR] calls). Participants’ demographic characteristics and CGM data were collected from medical records. The analyses focused on differences in openness to mHealth and mHealth communication channels across groups defined by demographic variables and measures of glycemic control. Results Among all participants (N=310; female: n=198, 63.9%; mean age 45, SD 16 years), 98.1% (n=304) reported active cellphone use and 80% (n=248) were receptive to receiving mHealth support to improve glucose control. Among participants receptive to mHealth support, 98% (243/248) were willing to share CGM glucose data for mHealth diabetes self-care assistance. Most (176/248, 71%) were open to receiving messages via apps, 56% (139/248) were open to SMS text messages, and 12.1% (30/248) were open to IVR calls. Older participants were more likely to prefer SMS text messages (P=.009) and IVR calls (P=.03) than younger participants. Conclusions Most people with T1D who use advanced diabetes technologies have access to cell phones and are receptive to receiving mHealth support to improve diabetes control.
Urban shrinkage in post-socialist countries

The article has two main tasks. On the one hand, it attempts to perform a comparative analysis of the shrinkage process of post-socialist cities in an international perspective and to formulate generalisations and recommendations. On the other hand, it presents the specificity of this process in various national, regional and local contexts. The analysis covers selected countries located in post-socialist Europe (with emphasis on East-Central and Southeast Europe), Russia and China and is focused on three issues: 1) geography of the shrinkage process of post-socialist cities; 2) common and country-specific factors responsible for urban shrinkage; 3) comparative analysis and conclusions in the context of managing urban shrinkage. The article points to the fact that urban shrinkage (especially in terms of demography) is one of the world challenges (with its scale being particularly large in post-socialist Europe), and the COVID-19 pandemic has started to affect its course and spatial distribution. The following key problems associated with the shrinkage of post-socialist cities are identified: 1) overcoming the demographic crisis; 2) demographic compensation for the migration outflow of the population; 3) overcoming the negative consequences of deindustrialization; 4) the problem of “wild” uncontrolled suburbanization, etc.
Converter Lifetime Assessment for Doubly-Fed Induction Generators Considering Derating Control Strategies at Low Rotor Frequencies

In this paper, various control strategies around the synchronous operating point with the aim to reduce the thermal loading of the rotor-side converter in wind turbines equipped with doubly-fed induction generators are investigated regarding their assets and drawbacks. It is shown that there are various possibilities to prolong the lifetime expectation of the converter regarding its thermal stress by implementing these control strategies. However, every control measure requires a careful design process or a slight adjustment of the system to ensure a positive effect on the overall behaviour of the wind turbine.