Miracle-dz/UniFAR-FTUs huggingface dataset:
Urbanscape Switzerland : topology and regional development in Switzerland, investigations and case studies

Settlement areas today can no longer be aptly described as either "urban" or "rural". We now live in sprawling conglomerations, collages of urban, suburban, and rural elements. New political solutions need to be found, challenging the institutional framework of federalism and the concept of local government. Commissioned by the foundation 'avenir suisse' (Think Tank for Economic and Social Issues), this publication gathers contributions by experts from the fields of sociology, geography, politics, economics and architecture, including Winy Maas' (MVRDV) vision for a Switzerland of the future. Whilst focusing on Switzerland as a case study, this book is a thought-provoking report on the gradual changes taking place in all industrialised countries. Angelus Eisinger teaches at the Department of Architecture at the Swiss Federal Institute of Technology in Zurich. Michael Schneider is the project leader at 'avenir suisse'.
PURCHASE INTENSITY ANALYSIS OF MUSLIM MILLENNIAL CONSUMERS WITH YOUTUBE FOOD CONTENT

Indonesian millennial consumers are potential consumers in business because they spend much time on social media interaction. This research was conducted in Indonesia by distributing questionnaires through Google Forms to 200 respondents using a purposive sampling technique. The analytical technique used in this study is the structural equation modeling (SEM) method with a partial least squares (PLS) approach. The results show that millennials’ purchase intention is not influenced by the number of views, likes, comments, and replies (VLCR) but by information source credibility. However, video characteristics, information quality, and perceived usefulness of the information in YouTube content have a significant effect on Indonesian millennials’ purchase intention
HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers

Infection with human papillomaviruses (HPVs), in particular with HPV type 16, is now considered to be a key risk factor for the development of a subset of oropharyngeal squamous cell carcinomas (OPSCC) that show different epidemiological, clinical, and prognostic characteristics from HPV-negative (HPV−) OPSCCs. So far, extensive research efforts aiming to distinguish these two distinct entities have not identified specific biomarkers, nor led to different therapies. Previous research has shown that HPV16 E6 oncoprotein binds NHERF2, inducing its proteasomal degradation, and consequently increasing cell proliferation; we therefore aimed to investigate how this might be reflected in human histological samples. We analyzed NHERF2 expression patterns in HPV16-positive (HPV16+) and HPV− OPSCC samples, to investigate any potential differences in NHERF2 pattern. Interestingly, we observed a statistically significant decrease in NHERF2 levels in HPV16+ and poorly differentiated HPV− OPSCCs, compared with healthy tissue. Furthermore, we observed a significant reduction in the percentage of NHERF2 immunoreactive cancer cells in HPV16+ tumors, compared with well and moderately differentiated HPV− OPSCCs, suggesting the importance of 16E6’s targeting of NHERF2 in HPV-driven oncogenesis in the head and neck area.
The effects of a smartphone game training intervention on executive functions in youth soccer players: a randomized controlled study

Cognitive training primarily aims to improve executive functions (EFs). It has become a popular research topic, as previous studies have provided preliminary evidence that EFs relate to sports performance. However, whether a domain-generic cognitive training intervention can improve EFs in high-performance athletes is still unclear. The present randomized controlled study aimed to examine the effects of an eight-week (5 min/day, 5 days/week) smartphone-based domain-generic cognitive training intervention (i.e., the smartphone game “Fruit Ninja”) on EFs in youth soccer athletes (N = 33; intervention: n = 15, passive control: n = 18; German youth soccer academy). We assessed working memory (3-back task), inhibition (Flanker & Go/NoGo task), and cognitive flexibility (number-letter task) in a pre-post design with computerized tasks. The results showed no significant time x group differences attributable to the cognitive training between the intervention group and the control group, except for a response time variable of the Go/NoGo task. These preliminary results do not suggest an application of CT as a smartphone-based game to improve EFs performance in soccer players. However, more research is needed to establish the efficacy of domain-specific interventions in high-level team sport athletes.
Bioaugmentation Potential Investigation Using a Phenol Affinity Analysis of Three Acinetobacter Strains in a Multi-Carbon-Source Condition

Bioaugmentation potential and phenol substrate affinity in a multi-carbon-source condition for three Acinetobacter strains (Acinetobacter towneri CFII-87, Acinetobacter johnsonii CFII-99A and Acinetobacter sp. CFII-98) were demonstrated. First, the phenol biodegradation ability of the strains was analyzed in batch experiments with phenol as the sole carbon source. All strains degraded phenol at 100 and 500 mg·L−1 initial concentrations; the maximum specific growth rates were 0.59 and 0.30 d−1 for A. towneri CFII-87, 0.50 and 0.20 d−1 for A. johnsonii CFII-99A, and 0.64 and 0.29 d−1 for A. sp. CFII-98, respectively. For the two tested phenol concentrations, no lag phase was observed for the A. towneri CFII-87 strain, A. sp. CFII-98 presented 4 h and 8 h lag phase, while A. johnsonii CFII-99A presented 3 h and 12 h lag phases. Phenol carbon source dependency of the strains was tested in a multi-carbon-source condition (on phenol-rich synthetic wastewater), both for individual strains and for a consortium prepared as an equal mixture of the three strains. The strains A. towneri CFII-87 and A. sp. CFII-98 and the consortia degraded phenol in 16 h while there was no other significant carbon source consumption during the 48 h trial, as shown by the constant non-phenolic residual chemical oxygen demand (COD) and volatile suspended solids (VSS) concentration after the depletion of phenol. The strain A. johnsonii CFII-99A, however, consumed phenol within 24 h and a further decrease in non-phenolic COD and increase in biomass was also observed upon the depletion of phenol. The highest specific phenol removal rate of 282.11 mg phenol·g VSS∙h−1 was observed in the case of the strain A. towneri CFII-87, followed by A. sp. CFII-98, the consortium and A. johnsonii CFII-99A with 178.84, 146.76 and 141.01 mg phenol·g VSS∙h−1, respectively. Two bacterial strains (A. towneri CFII-87, A. sp. CFII-98) presented a strong affinity to phenol, utilizing it as a primary carbon source, and thus, their use in the bioaugmentation of wastewater bioreactors indicated the viable potential to increase the phenol removal rate of these systems.
Four-dimensional flow magnetic resonance imaging visualizes reverse vortex pattern and energy loss increase in left bundle branch block.

AIMS This study aimed to investigate the intraventricular blood flow pattern of patients with left bundle branch block (LBBB) using four-dimensional flow magnetic resonance imaging (4D-flow MRI). METHODS AND RESULTS We performed 4D-flow MRI for 16 LBBB patients (LBBB group) and 16 propensity score-matched patients with a normal QRS duration (non-LBBB group). The energy loss (EL) in the left ventricle was evaluated. In both groups, blood flow from the mitral valve to the apex of the heart and left ventricular (LV) outflow tract during LV diastole were observed. Vortices were also observed in both groups. There were two patterns of vortices: unidirectional clockwise rotation and counterclockwise rotation taking place from the mid-diastole to the systole (reverse pattern). The reverse pattern was observed significantly more frequently in the LBBB group (LBBB 94% vs. non-LBBB 19%, P < 0.001). The interobserver agreement for the streamline analysis was good (kappa = 0.68). The maximum EL was significantly higher in the LBBB group [LBBB 12 (11-15) mW vs. non-LBBB 8.0 (6.2-9.7) mW, P < 0.001]. CONCLUSION Left bundle branch block patients may suffer from inefficient LV haemodynamics reflected by non-physiological counterclockwise vortices and increased EL. Thus, the shape of the vortices and EL in the left ventricle can serve as markers of LV mechanical dyssynchrony in LBBB patients and could be investigated as predictors of response to cardiac resynchronization therapy.
One case of comorbidity benefit of secukinumab for severe plaque psoriasis

: The patient was a 66-year-old male with recurrent erythematous and scaly plaques all over the body for more than 16 years. Generalized erythema on the head, trunk, and extremities, with some plaques fusing to form a map, covered with oyster shell-like hypertrophic white scales, film phenomenon (+), punctate hemorrhage (+), localized skin visible as scabs, scratches, and mossy changes, no pustules or joint swelling or deformity. Skin condition: PASI score: 56; BSA: 70%; DLQI: 17. Diagnosis: severe plaque psoriasis Metabolic syndrome. After administration of traditional treatments such as avitamin A, carbotriol ointment and glucocorticoids, which were ineffective, the skin lesions returned to normal and the psoriasis co-morbidities improved without adverse effects after treatment with stauchyuzumab.
MOC3D adapted to simulate 3D density-dependent groundwater flow

The three-dimensional computer code MOC3D (Konikow et al., 1996) is adapted for density differences: MOCDENS3D. As a result, it is possible to model transient three-dimensional groundwater flow in large-scale hydrogeologic systems where non-uniform density distributions occur. A special field of application is the simulation of salt water intrusion in coastal aquifers. The groundwater flow equation is solved by the MODFLOW module of MOCDENS3D. Density differences are taken into account through adding buoyancy terms to the RHS term of the basic groundwater flow equation of MODFLOW. The advection-dispersion equation is solved by the MOC module, using the method of characteristics. Advective transport of solutes is modeled by means of particle tracking and dispersive transport by means of the finite difference method. An advantage of applying the method of characteristics is that the condition of spatial discretisation is not strict. As a consequence, the displacement of fresh, brackish and saline groundwater in large-scale hydrogeologic systems can easily be modeled. Finally, the evolution of a freshwater lens at a circular sandy island is shortly discussed.
Pelargonium capitatum y Rumez lunaria, dos plantas invasoras en el Parque Nacional de Timanfaya (Lanzarote, Islas Canarias): Consideraciones ecológicas y fitosociológicas

espanolTras una breve sinopsis del marco fisico y la flora del Parque, se discute la problematica surgida por la invasion en este ecosistema del neofito Pelargonium capitatum y el endemismo canario occidental Rumex lunaria, cuya desmedida propagacion en anos recientes plantea un dificil problema en la conservacion del Parque; asi mismo, se realizan consideraciones fitosociologicas al respecto. Finalmente se comentan ciertos aspectos sobre la colonizacion y sucesion vegetal en el Parque Nacional de Timanfaya EnglishIn this paper we come up to the problematic invasion in the National Park of Timanfaya of Pelargonium capitatum (neophyte) and Rumex lunaria (western canarian endemic plant), which make appear a problem in the conservation of the Par k; phytosoci ological data are provided. Moreover, sorne comentaries about the physical characteristics, flora, and consideration of the plant colonization and succession, are given
Benefits of Adolescent Women's Reproductive Health Records as a Basis for Screening Preconception Care: A Research and Development Study

The health status of women is one of the factors that can affect the status of pregnancy. To avoid risky pregnancies and produce healthy babies, it is very important for a woman to take care of her reproductive health. One of the efforts is to conduct early detection on a regular basis starting from the age of teenagers. This developmental research was carried out using the Four-D model, to obtain a simple early detection medium in preconception care. Sixty selected young women participated in a limited trial. Respondents who participate in a limited-scale trial will go through 3 stages. The data obtained were analyzed descriptively. The success of using the application as a function of simple screening media for preconception care reached 96.67%. It was identified that 57% of adolescent girls were detected to have health problems such as poor nutritional status and anemia. A total of 71.7% stated that this application applies very well on adolescent girls in order to keep them healthy as an initial step in preparation for pregnancy. As many as 73.3% of respondents stated that the developed application provided new knowledge related to preconception preparation. There is strong evidence that the resulting media performs well as a simple early detection tool for preconception care. Therefore, it needs to be refined to provide more optimal results. Keywords: screening, preconception, adolescent
JUVENILE IDIOPATHIC ARTHRITIS ASSOCIATED WITH INCOMPLETE PRIMARY HYPERTROPHIC OSTEOARTHROPATHY (PACHYDERMOPERIOSTOSIS)

Introduction. Hypertrophic osteoarthropathy (HOA) is a rare, hereditary disease characterized by clubbing and new bone formation in the periosteal region that may be associated with joint pain, cutaneous abnormalities, seborrhea or hyperhydrosis. Juvenile idiopathic arthritis (JIA) is one of the most frequent chronic diseases with childhood onset, patients develop inflammatory joint pain and extra-articular manifestations with imunologic substrate. The association of the two diseases is very rare. 24 years old patient related disease onset at the age of 14 with arthritis of proximal interphalangeal joints (PIP), knees and right ankle. He is diagnosed with oligoarticular form of juvenile idiopathic arthritis. He receives Methotrexate, Suphasalazyne and association of the two, but after 5 years biological therapy with Etanercept is started. Later on, repeated physical examination revealed digital clubbing, non-painful enlargment of hands and feet with sweaty teguments. Radiological examination with subperiosteal new bone formation of the distal tibia, the fibula, the radius, the ulna, the metacarpals and the phalanges confirms the suspicion of HOA – pachydermoperiostosis (PDP). Conclusion. Final diagnosis considers both entities. The incomplete form of PDP included hands and feet enlargement with extensive periostitis, palmoplantar hyperhydrosis, but no significant facial changes. The specific treatment for JIA did not influence the evolution of PDP.
Simple Numerical Calculation Method of Rotational Iron Loss in Silicon Steel Sheets

To evaluate the iron losses of motors and three-phase transformers, the rotational iron loss should be considered. A simple numerical calculation method of the rotational iron losses under rotational flux with high flux density and different axis ratios is proposed in this paper. First, it is shown that the method of decomposing the rotational flux into the directions of the major and minor axes of the rotational flux is effective in calculating the rotational iron losses of the non-oriented and grain-oriented electrical steel sheets in low magnetization region. Then, the simple iron loss calculation method is improved to consider the decrease of rotational hysteresis and anomalous eddy current losses in high magnetization region under circular rotational flux and verified by comparing with measurement results. Furthermore, it is improved to be applicable to rotational iron loss calculation under rotational flux with different axis ratios and verified by comparing with measurement results.
A new species of threadsnake in the genus Myriopholis (Squamata: Scolecophidia: Leptotyplophidae) from southeastern Kenya

ABSTRACT A new threadsnake species from the family Leptotyphlopidae, Myriopholis mackayi sp. nov., is described from the Tsavo area in southeastern Kenya. Myriopholis mackayi sp. nov. is a member of the Myriopholis longicauda group on the basis of having a low number of middorsal scales, a discrete frontal shield, a rounded snout, a small anterior supralabial, a moderate posterior supralabial, semilunar cloacal shield, and pinkish colouration in life (brown dorsum and tan venter after preservation). The species is known from a xeric habitat at moderate elevation. It is highly recommended that future phylogenetic work is done to establish its taxonomic relations to other leptotyphlopids.
Expression of toll-like receptor 4 and its associated cytokines from peripheral blood mononuclear cells in Leghorn chickens

Background and Aim: Immune cells require toll-like receptor 4 (TLR4) to respond to lipopolysaccharides (LPS) by releasing pro-inflammatory cytokines. Peripheral blood mononuclear cells (PBMCs) are used to assess changes in cytokines released in response to diseases or pathogens. This study aimed to assess TLR4 gene expression in PBMCs from Leghorn chicken and the release of related cytokines. Materials and Methods: Peripheral blood mononuclear cells were isolated from blood samples obtained from Leghorn chicks. The PBMC cultures were stimulated with various concentrations of LPS (0.01-1 μg/ml). Polymerase chain reaction was used to detect TLR4 expression. The production of tumor necrosis factor-alpha (TNF-α) and interleukins (IL-1β and IL-6) was quantified using an enzyme-linked immunosorbent assay. Results: We found that TLR4 was expressed in both non-stimulated and stimulated Leghorn chicken PBMCs. In addition, the release of TNF-α, IL-1β, and IL-6 levels in Leghorn chicken PBMCs increased significantly with an increase in LPS concentration (0.01–1 μg/mL) (p < 0.05). Conclusion: Although TLR4 was expressed in both non-stimulated and stimulated Leghorn chicken PBMCs, its expression was significantly higher in LPS-stimulated PBMCs Therefore, the chicken’s endotoxin response can be assessed by evaluating the pro-inflammatory cytokine production from PBMCs.
An Ultra-Compact and Wideband Transformer-Based Coupler With Arbitrary Phase Difference and Arbitrary Power Division Ratio

This article presents a wideband ultra-compact transformer-based lumped coupler that offers an arbitrary phase difference and power division ratio (PDR) between the two output ports, while maintaining input-output matching and isolation conditions. The transformer-based lumped design of the coupler ensures a compact layout and is conducive to ON-chip implementations. In addition, the inherent high-order network nature of the physical transformer achieves wideband performance. The design theory of the proposed coupler is analyzed and the closed-form design equations for the values of the components are derived. As a proof of concept, four different 45° / 60° prototypes with equal and unequal PDRs are implemented in GlobalFoundries 22-nm CMOS FD-SOI technology at 55–60 GHz. The measurements of the coupler prototypes are in good agreement with the electromagnetic (EM) simulation results and the performance predicted by the theoretical analysis. They demonstrate that the proposed transformer-based coupler with arbitrary phase difference and arbitrary PDR is capable of achieving at least $14\times $ smaller size compared to previously reported transmission-line/coupled-line implementations and around 15%–20% larger fractional bandwidth (FBW) compared to previously reported lumped coupler implementations.
Intake of Lactiplantibacillus plantarum HEAL9 Improves Cognition in Moderately Stressed Subjects: A Randomized Controlled Study

Background: The usage of probiotics has expanded beyond the areas of gut and immune health improvement. Several studies have shown the positive impact associated between probiotics and stress, cognition, and mood; a relationship referred to as the gut–brain axis. Method: The aim of this exploratory study was to evaluate the effect of the probiotic strain Lactiplantibacillus plantarum HEAL9 (LPHEAL9) on the gut–brain axis in subjects with moderate stress. One hundred and twenty-nine subjects aged 21–52 years completed the study, randomized to consume either LPHEAL9 (n = 65) or placebo (n = 64) for 12 weeks. Results: Perceived stress and awakening cortisol were significantly reduced over time in both groups. A significant improvement in four cognition tests after consumption of LPHEAL9 compared to placebo was observed (rapid information processing test, numeric working memory test, paired associated learning, and word recall, p < 0.05). There was a tendency for a significantly better improvement in the LPHEAL9 group for three mood subscales (Confusion–Bewilderment, Anger–Hostility, and Depression–Dejection) and for fewer subjects with poor sleep in the LPHEAL9 group compared to placebo (p < 0.10). Conclusions: Intake of LPHEAL9 significantly improved cognitive functions compared to the placebo, potentially by ameliorating aspects of mood and sleep.
Intake of Lactobacillus plantarum HEAL9 reduces the inflammatory markers soluble fractalkine and CD163 during acute stress: A randomized, double blind, placebo-controlled study

Please cite this article as: Gunilla Önning , Magnus Hillman , Maria Hedin , Caroline Montelius , Joakim Eriksson , Siv Ahrné , Peter Jönsson , Intake of Lactobacillus plantarum HEAL9 reduces the inflammatory markers soluble fractalkine and CD163 during acute stress: A randomized, double blind, placebo-controlled study, Physiology & Behavior (2020), doi: https://doi.org/10.1016/j.physbeh. 2020.113083
How children learn to understand language meanings: a neural model of adult–child multimodal interactions in real-time

This article describes a biological neural network model that can be used to explain how children learn to understand language meanings about the perceptual and affective events that they consciously experience. This kind of learning often occurs when a child interacts with an adult teacher to learn language meanings about events that they experience together. Multiple types of self-organizing brain processes are involved in learning language meanings, including processes that control conscious visual perception, joint attention, object learning and conscious recognition, cognitive working memory, cognitive planning, emotion, cognitive-emotional interactions, volition, and goal-oriented actions. The article shows how all of these brain processes interact to enable the learning of language meanings to occur. The article also contrasts these human capabilities with AI models such as ChatGPT. The current model is called the ChatSOME model, where SOME abbreviates Self-Organizing MEaning.