Miracle-dz/UniFAR-FTUs huggingface dataset:
Functional Role and Truth Conditions

This paper is about truth-conditional content from the point of view of a use theory of meaning. I shall be taking up the question of how a use theory of meaning should deal with cases where uses of words might be said to be the same, but truth conditions differ-specifically Putnam's 'twin earth' cases. ' The background issue is whether there is a legitimate notion of meaning or content that is purely 'inside the head'-not dependent on the external context of things referred to or on the language community. This paper defends the legitimacy of this 'narrow content' conception in the following limited way: I argue that use theories of meaning must deal with truth conditions in a way that leaves room for narrow content.
Faecal microbiota transplantation from young rats attenuates age‐related sarcopenia revealed by multiomics analysis

Gut microbiota plays a key role in the development of sarcopenia via the ‘gut‐muscle’ axis, and probiotics‐based therapy might be a strategy for sarcopenia. Fecal microbiota transplantation from young donors (yFMT) has attracted much attention because of its probiotic function. However, whether or not yFMT is effective for sarcopenia in old recipients is largely unknown. Thus, we aimed to investigate the effect and mechanism of yFMT on age‐related sarcopenia.
Pediatric Aerodigestive Medicine: Advancing Collaborative Care for Children With Oropharyngeal Dysphagia

Objectives: Aerodigestive disorders encompass various pathological conditions affecting the lungs, upper airway, and gastrointestinal tract in children. While advanced care has primarily occurred in specialty centers, many children first present to general pediatric gastroenterologists with aerodigestive symptoms necessitating awareness of these conditions. At the 2021 Annual North American Society for Pediatric Gastroenterology, Hepatology and Nutrition meeting, the aerodigestive Special Interest Group held a full-day symposium entitled, Pediatric Aerodigestive Medicine: Advancing Collaborative Care of Children with Aerodigestive Disorders. The symposium aimed to underline the significance of a multidisciplinary approach to achieve better outcomes for these complex patients. Methods: The symposium brought together leading experts to highlight the growing aerodigestive field, promote new scientific and therapeutic strategies, share the structure and benefits of a multidisciplinary approach in diagnosing common and rare aerodigestive disorders, and foster multidisciplinary discussion of complex cases while highlighting the range of therapeutic and diagnostic options. In this article, we showcase the diagnostic and therapeutic approach to oropharyngeal dysphagia (OPD), one of the most common aerodigestive conditions, emphasizing the role of a collaborative model. Conclusions: The aerodigestive field has made significant progress and continues to grow due to a unique multidisciplinary, collaborative model of care for these conditions. Despite diagnostic and therapeutic challenges, the multidisciplinary approach has enabled and greatly improved efficient, high-quality, and evidence-based care for patients, including those with OPD.
Intensive care unit sinks are persistently colonized with multidrug resistant bacteria and mobilizable, resistance-conferring plasmids

ABSTRACT Contamination of hospital sinks with microbial pathogens presents a serious potential threat to patients, but our understanding of sink colonization dynamics is largely based on infection outbreaks. Here, we investigate the colonization patterns of multidrug-resistant organisms (MDROs) in intensive care unit sinks and water from two hospitals in the USA and Pakistan collected over 27 months of prospective sampling. Using culture-based methods, we recovered 822 bacterial isolates representing 104 unique species and genomospecies. Genomic analyses revealed long-term colonization by Pseudomonas spp. and Serratia marcescens strains across multiple rooms. Nanopore sequencing uncovered examples of long-term persistence of resistance-conferring plasmids in unrelated hosts. These data indicate that antibiotic resistance (AR) in Pseudomonas spp. is maintained both by strain colonization and horizontal gene transfer (HGT), while HGT maintains AR within Acinetobacter spp. and Enterobacterales, independent of colonization. These results emphasize the importance of proactive, genomic-focused surveillance of built environments to mitigate MDRO spread. IMPORTANCE Hospital sinks are frequently linked to outbreaks of antibiotic-resistant bacteria. Here, we used whole-genome sequencing to track the long-term colonization patterns in intensive care unit (ICU) sinks and water from two hospitals in the USA and Pakistan collected over 27 months of prospective sampling. We analyzed 822 bacterial genomes, representing over 100 different species. We identified long-term contamination by opportunistic pathogens, as well as transient appearance of other common pathogens. We found that bacteria recovered from the ICU had more antibiotic resistance genes (ARGs) in their genomes compared to matched community spaces. We also found that many of these ARGs are harbored on mobilizable plasmids, which were found shared in the genomes of unrelated bacteria. Overall, this study provides an in-depth view of contamination patterns for common nosocomial pathogens and identifies specific targets for surveillance. Hospital sinks are frequently linked to outbreaks of antibiotic-resistant bacteria. Here, we used whole-genome sequencing to track the long-term colonization patterns in intensive care unit (ICU) sinks and water from two hospitals in the USA and Pakistan collected over 27 months of prospective sampling. We analyzed 822 bacterial genomes, representing over 100 different species. We identified long-term contamination by opportunistic pathogens, as well as transient appearance of other common pathogens. We found that bacteria recovered from the ICU had more antibiotic resistance genes (ARGs) in their genomes compared to matched community spaces. We also found that many of these ARGs are harbored on mobilizable plasmids, which were found shared in the genomes of unrelated bacteria. Overall, this study provides an in-depth view of contamination patterns for common nosocomial pathogens and identifies specific targets for surveillance.
A Unified Framework for Both Graph and Pattern Matching Using IPaMWAG

: In general the matter of finding sub graphs that best match a user’s query on weighted Attributed Graphs (wags) is an open research area. There is a tendency to outline a WAG as a graph where every nodes exhibit multiple attributes with varied, non-negative weights. An example of a WAG could be a coauthor ship network, wherever every author has multiple attributes, every such as a specific topic (e.g., databases, data processing, and machine learning), and therefore the quantity of experience in a very specific topic is delineate by a non-negative weight on it attribute. A typical user query during this setting specifies each property patterns between query nodes and constraints on attribute weights of the query nodes. A ranking perform that unifies the matching on attribute weights over the nodes and on the graph structure is proposed. To prove that the matter of retrieving the best match for such queries is complete. Moreover, there is a tendency to propose a quick and effective top-k pattern matching algorithm and top-k graph search algorithm for weighted attributed graphs. In an intensive experimental study with multiple real-world datasets, the projected algorithm exhibits important speed-up over competitive approaches. On average, projected technique is quicker in query process than the strongest competitive technique.
Long-term Performance and Safety of Princess VOLUME PLUS Lidocaine for Midface Augmentation: The PRIMAvera Clinical Study

Abstract Background Hyaluronic acid–based dermal fillers are the most applied medical devices for midface augmentation. Objectives This postmarket investigation evaluated the long-term performance and safety of and patient satisfaction with Princess VOLUME PLUS Lidocaine (PVPL; now Saypha VOLUME PLUS Lidocaine) for the correction of midface volume deficit (MVD). Methods This was an open-label, prospective, interventional, multicenter, noncomparative, postapproval study of 91 patients with moderate or severe MVD (grade 2 or 3 on the 5-point Midface Volume Deficit Severity Scale, or MVDSS). At Day 0 (Visit 1), patients were treated with PVPL; they returned for follow-up assessments at weeks 2, 4, 12, 24, 36, and 52 and had long-term follow-up until 36 months. A touch-up treatment could be done at week 2. The performance was assessed with the MVDSS, Global Aesthetic Improvement Scale (GAIS), and a subject satisfaction scale. Adverse events were collected to assess safety throughout the study. Results Four weeks after treatment, 100% of injected patients improved by ≥1 grade on the MVDSS compared to baseline, with improvements still visible in 77% of patients 52 weeks after treatment. Based on the GAIS and post hoc survival analysis, the treatment effect was maintained for a median of 386 days, and in severe cases the effect lasted longer, which seemed to be independent of the volume injected at baseline. No serious side effects were reported. Results were substantiated by high patient satisfaction. Conclusions Princess VOLUME PLUS Lidocaine was perceived as safe and effective by patients and investigators, with long-term aesthetic improvement in moderate and severe cases. Level of Evidence: 3
Intégration et Espaces de Sobolev à Valeurs Vectorielles.

Partant de la theorie d'integration de Lebesgue pour les fonctions a valeurs scalaire, nous developpons la theorie correspondante pour les fonctions a valeurs dans des espaces de Banach. Nous abordons ensuite la question des espaces de Sobolev pour les fonctions a valeurs dans des Banach. Plusieurs resultats etablis ici (de densite, compacite, integration-par-parties, etc.) sont directement motives par leur utilite dans l'etude des equations au derivees partielles paraboliques non-lineaires.
RECIST-Induced Reliable Learning: Geometry-Driven Label Propagation for Universal Lesion Segmentation

Automatic universal lesion segmentation (ULS) from Computed Tomography (CT) images can ease the burden of radiologists and provide a more accurate assessment than the current Response Evaluation Criteria In Solid Tumors (RECIST) guideline measurement. However, this task is underdeveloped due to the absence of large-scale pixel-wise labeled data. This paper presents a weakly-supervised learning framework to utilize the large-scale existing lesion databases in hospital Picture Archiving and Communication Systems (PACS) for ULS. Unlike previous methods to construct pseudo surrogate masks for fully supervised training through shallow interactive segmentation techniques, we propose to unearth the implicit information from RECIST annotations and thus design a unified RECIST-induced reliable learning (RiRL) framework. Particularly, we introduce a novel label generation procedure and an on-the-fly soft label propagation strategy to avoid noisy training and poor generalization problems. The former, named RECIST-induced geometric labeling, uses clinical characteristics of RECIST to preliminarily and reliably propagate the label. With the labeling process, a trimap divides the lesion slices into three regions, including certain foreground, background, and unclear regions, which consequently enables a strong and reliable supervision signal on a wide region. A topological knowledge-driven graph is built to conduct the on-the-fly label propagation for the optimal segmentation boundary to further optimize the segmentation boundary. Experimental results on a public benchmark dataset demonstrate that the proposed method surpasses the SOTA RECIST-based ULS methods by a large margin. Our approach surpasses SOTA approaches over 2.0%, 1.5%, 1.4%, and 1.6% Dice with ResNet101, ResNet50, HRNet, and ResNest50 backbones.
How Cryo-EM Has Expanded Our Understanding of Membrane Transporters

Over the past two decades, technological advances in membrane protein structural biology have provided insight into the molecular mechanisms that transporters use to move diverse substrates across the membrane. However, the plasticity of these proteins’ ligand binding pockets, which allows them to bind a range of substrates, also poses a challenge for drug development. Here we highlight the structure, function, and transport mechanism of ATP-binding cassette/solute carrier transporters that are related to several diseases and multidrug resistance: ABCB1, ABCC1, ABCG2, SLC19A1, and SLC29A1. SIGNIFICANCE STATEMENT ATP-binding cassette transporters and solute carriers play vital roles in clinical chemotherapeutic outcomes. This paper describes the current understanding of the structure of five pharmacologically relevant transporters and how they interact with their ligands.
An 8‐channel Tx dipole and 20‐channel Rx loop coil array for MRI of the cervical spinal cord at 7 Tesla

The quality of cervical spinal cord images can be improved by the use of tailored radiofrequency (RF) coil solutions for ultrahigh field imaging; however, very few commercial and research 7‐T RF coils currently exist for the spinal cord, and in particular, those with parallel transmission (pTx) capabilities. This work presents the design, testing, and validation of a pTx/Rx coil for the human neck and cervical/upper thoracic spinal cord. The pTx portion is composed of eight dipoles to ensure high homogeneity over this large region of the spinal cord. The Rx portion is made up of twenty semiadaptable overlapping loops to produce high signal‐to‐noise ratio (SNR) across the patient population. The coil housing is designed to facilitate patient positioning and comfort, while also being tight fitting to ensure high sensitivity. We demonstrate RF shimming capabilities to optimize B1+ uniformity, power efficiency, and/or specific absorption rate efficiency. B1+ homogeneity, SNR, and g‐factor were evaluated in adult volunteers and demonstrated excellent performance from the occipital lobe down to the T4‐T5 level. We compared the proposed coil with two state‐of‐the‐art head and head/neck coils, confirming its superiority in the cervical and upper thoracic regions of the spinal cord. This coil solution therefore provides a convincing platform for producing the high image quality necessary for clinical and research scanning of the upper spinal cord.
Perianal plaques, acral bullae, and desquamation in a neonate

anti-Dsg3 antibodies can be helpful in diagnosing neonatal pemphigus vulgaris. The diagnosis of congenital syphilis is based on reactive maternal and infant nontreponemal and treponemal testing. 7 Although the diagnosis of pemphigus syphiliticus does not require a biopsy, histopathology may show neutrophilic intraepidermal vesicles, spongiosis, and acanthosis. Plasma cells may be present. Immunohistochemical staining for T. pallidum should demonstrate intraepidermal spirochetes, confirming the diagnosis. 8 Early detection of maternal infection and treatment with penicillin G benzathine is crucial to prevent neonatal deafness, bone deformities, neurologic impairments, prema-ture delivery, low birth weight, still birth and even death. 7,9,10 With increasing rates of congenital syphilis, clinicians should have a high index of suspicion for congenital syphilis in newborns presenting with acral bullae, erosions, and desquamation. Given the morbidity and mortality associated with congenital syphilis, early recognition of the cutaneous manifestations of syphilis by dermatologists is crucial to initiating early treatment to prevent long-term sequelae.
Laboratory Diagnosis of Mpox, Central African Republic, 2016–2022

During 2016–2022, PCR testing confirmed 100 mpox cases among 302 suspected cases in the Central African Republic. The highest detection rates were from active lesions (40%) and scabs (36%); cycle thresholds were lower (≈18) than those for blood samples (≈33). Results were consistent for generic primer– and clade I primer–specific PCR tests.
Robust and protective immune responses induced by heterologous prime‐boost vaccination with DNA‐protein dimeric RBD vaccines for COVID‐19

The coronavirus disease 2019 (COVID‐19) pandemic posed great impacts on public health. To fight against the pandemic, robust immune responses induced by vaccination are indispensable. Previously, we developed a subunit vaccine adjuvanted by aluminum hydroxide, ZF2001, based on the dimeric tandem‐repeat RBD immunogen, which has been approved for clinical use. This dimeric RBD design was also explored as an mRNA vaccine. Both showed potent immunogenicity. In this study, a DNA vaccine candidate encoding RBD‐dimer was designed. The humoral and cellular immune responses induced by homologous and heterologous prime‐boost approaches with DNA‐RBD‐dimer and ZF2001 were assessed in mice. Protection efficacy was studied by the SARS‐CoV‐2 challenge. We found that the DNA‐RBD‐dimer vaccine was robustly immunogenic. Priming with DNA‐RBD‐dimer followed by ZF2001 boosting induced higher levels of neutralizing antibodies than homologous vaccination with either DNA‐RBD‐dimer or ZF2001, elicited polyfunctional cellular immunity with a TH1‐biased polarization, and efficiently protected mice against SARS‐CoV‐2 infection in the lung. This study demonstrated the robust and protective immune responses induced by the DNA‐RBD‐dimer candidate and provided a heterologous prime‐boost approach with DNA‐RBD‐dimer and ZF2001.
Optimal needle electromyography approach to the serratus anterior muscle

There are two conventional needle electromyography (EMG) approaches to the serratus anterior (SA), both of which can result in erroneous insertion into adjacent structures such as the latissimus dorsi (LD), teres major, or external oblique abdominis muscles and pose a risk of long thoracic nerve (LTN) injury. Therefore, we identified a novel needle insertion point for the SA in cadavers that avoids other muscles and LTN injury.
Pharyngeal Co-Infections with Monkeypox Virus and Group A Streptococcus, United States, 2022

We report 2 cases of pharyngeal monkeypox virus and group A Streptococcus co-infection in the United States. No rash was observed when pharyngitis symptoms began. One patient required intubation before mpox was diagnosed. Healthcare providers should be aware of oropharyngeal mpox manifestations and possible co-infections; early treatment might prevent serious complications.
Hurricane Satellite (HURSAT) data sets: Low-Earth orbit infrared and microwave data

Given the recent hypotheses relating longterm trends in tropical cyclone (TC) activity and global warming, there is a growing need for consistent reanalyses of the historical TC data. The hurricane satellite (HURSAT) data set provides a basis for consistent analysis. The HURSAT objective is to provide climatecalibrated satellite data to as wide a user base as possible for tropical cyclone research. The initial version of HURSAT-B1 data provided 3-hourly observations centered on global tropical cyclones with ~8km spatial resolution (Knapp and Kossin, 2007). This data was used to perform a re-analysis of tropical cyclone intensities during 1983-2005 (Kossin et al., 2007). However, more information on tropical storms is available from other satellite instruments. In particular, the Advanced Very High Resolution Radiometer (AVHRR) provides finer spatial resolution and the Special Sensing Microwave Imager (SSMI) provides information on atmospheric structure below the cloud top. The characteristics of each data set are summarized in Table 1. All HURSAT data are provided in NetCDF format. This allows users with experience in nearly any programming language to work with the data. The data are stored according to the Climate and Forecasting (CF) netCDF convention, which means that many software (e.g., IDV and GrADS) can read and process the data directly.
Mediators and Moderators in the Co-Occurring Anxiety and Alcohol Use Relationship: Protocol for a Systematic Review and Meta-Analysis

Background Anxiety and alcohol use commonly co-occur. Previous research has demonstrated the bidirectional and mutually reinforcing nature of this relationship, with an increasing body of research investigating the mediating and moderating mechanisms driving this association. Within the existing mediation and moderation research, however, there have been contrasting findings and, at times, null results among some population groups. Objective This protocol outlines a systematic review and meta-analysis aiming to synthesize and clarify mediators and moderators in the anxiety-alcohol and alcohol-anxiety relationships. Methods Systematic searches will be conducted in the electronic databases Medline, PsycINFO, Embase, Cochrane Central Register of Controlled Trials, Scopus, and Web of Science to identify studies that investigated mediators and moderators of the relationship between anxiety and alcohol use, including clinical and subclinical levels. Studies that look at the relationship between anxiety and alcohol use outcomes, as well as alcohol use and anxiety outcomes, will be included in order to capture an in-depth understanding of the mechanisms driving the association in either direction. No limits will be placed on study year or study language. Included study designs will be observational studies, including cohort, cross-sectional, and longitudinal studies, and secondary analyses of randomized controlled trials reporting quantitative results. Selected studies will also have their reference lists hand-searched for other relevant papers. Study quality will be assessed with the Joanna Briggs Institute Checklists for Analytical Cross-Sectional Studies and Cohort Studies. Mediators and moderators will be narratively synthesized in line with the biopsychosocial framework, where results will be grouped into biological, psychological, and social or environmental factors. If the data are sufficiently homogeneous, a meta-analysis will be conducted with mediation and moderation analyses synthesized separately. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework will also be used to assess the strength of cumulative evidence. Results Electronic database searches were conducted in September 2022. After duplicates were removed, a total of 7330 titles and abstracts were screened. Full-text reviewing is currently under way, with the results expected to be available by the end of 2023. Conclusions Given the significant individual and societal impacts of co-occurring anxiety and alcohol use, this review will help clarify mechanisms linking these two concerns. Identified mechanisms, where possible, can then be targeted in prevention, early intervention, and treatment approaches to improve the outcomes for individuals experiencing co-occurring anxiety and alcohol use. Trial Registration PROSPERO CRD42023358402; https://tinyurl.com/2m2e3enp International Registered Report Identifier (IRRID) DERR1-10.2196/48875