Miracle-dz/UniFAR-FTUs huggingface dataset:
Mesleki Öz Yeterlilik ile İş Performansı Arasındaki İlişkide Eğitim Seviyesinin Düzenleyici Rolü: Aşçılar Üzerine Bir Araştırma (The Regulatory Role of Education Level in the Relationship Between Professional Self-Efficacy and Job Performance: A Study on Cooks)

Bireylerin eğitimleri kendilerine olan inançlarını arttırır ve başarma inançları yüksek olan bireylerin performansları da o yönde artış gösterir. Mesleğe yönelik yeterlilik algısı bireylerin mesleklerinde gösterdikleri başarı oranlarında önemli yere sahiptir. Aşçılık mesleği, mesleki anlamda yeterli bilgi ve beceriye sahip olunması gereken bir meslektir. Bu araştırmanın amacı aşçıların mesleki öz yeterlilik algıları ile iş performansı arasındaki ilişkide eğitim seviyesinin düzenleyici rolünü belirlemektir. Araştırmanın amacı doğrultusunda, Pandemi sürecinde açık olan 22 konaklama işletmesinin mutfak departmanında aşçı pozisyonunda çalışan 163 bireye, 2021 yılı Ocak-Mart ayları arasında anket formu yardımıyla veriler toplanmıştır. Araştırmada konaklama işletmelerinde çalışan aşçıların mesleki öz yeterlilik algıları ile iş performansı arasındaki ilişkiyi belirlemek amacıyla korelasyon analizi, eğitim seviyesinin düzenleyici rolünü belirlemek için ise düzenleyici değişken regresyon analizi yapılmıştır. Araştırmada, konaklama işletmelerinde çalışan aşçıların eğitim seviyelerinin arttırılmasıyla mesleki öz yeterlilik algılarının yükselebileceği ve yüksek düzeydeki öz yeterliliğin iş performansını arttırabileceği tespit edilmiştir. Araştırma kapsamında aşçıların mesleki öz yeterlilik algıları ile iş performansı arasındaki ilişkinin eğitim seviyesi tarafından biçimlendiği sonucuna ulaşılmıştır.
Inverter-Based Microgrid Dynamic Stability Analysis Considering Inventory of Dynamic and Static Load Models

The proper and sustainable performance of any electrical system is mainly related to the designers' insight into the nature of that system. Therefore, the need to provide an accurate model based on the actual behavior of the system has considerable importance. In the case of inverter-based microgrid, due to the lack of sufficient synchronizing torque, the design process must be carried out with the utmost precision. In this paper, the stability of the inverter-based microgrid will be studied. First by presenting the equations of the microgrid components its state-space model is obtained and in the presence of the static load model the stability of the system will be investigated. Then, by placing the inventory of dynamic exponential recovery and static polynomial load models, the results of the static model-based design are investigated. In this study, the measure of system stability will be eigenvalue plots and system performance. In order to achieve system stability and performance improvement, the state variables participation factors extracted and the effective parameters will be studied.
Incremental Learning of Quantum Generative Adversarial Network

Machine learning field has shown incredible impact on many kinds of optimization problems. Recently the power of machine learning was applied to speed up the quantum states preparation. Although approximation with quantum generative adversarial networks is one of the fastest ways to prepare a generic quantum state, training time for such models is still significant and can easily impair quantum advantage. This thesis explores incremental learning of quantum generative adversarial networks for the quantum states preparation problem and introduces learning use cases reducing the training time.
Skin Lesions Images Super-Resolution to Assist Diagnosis

Converting a low-resolution skin image to a high-resolution one is essential to making correct diagnosis in many clinical scenarios. Several different approaches have been attempted to tackle this task, but it is challenging to restore resolution while preserving precise edge details. We aim to build a deep-learning end-to-end model that utilizes edge information to solve this problem. We experimented with GAN-based methods that are using canny edge maps or gradient maps (edge-informed SISR, modiﬁed SPSR) and segmentation-based methods based on gradient maps(modiﬁed Unet, modiﬁed Unet++). We found edge-informed SISR that utilized canny edge maps achieved both the highest human rating scores (both dermatologists and non-dermatologists) and the highest image sharpness, but the modiﬁed SPSR which used gradient maps had the shortest feature vector distance from HR images at a scaling factor of 4. Edge-informed SISR was also able to generate sharp details at a scaling factor of 8. (shown in Figure 1.)
Descriptive Epidemiology of Interruptions to Free-Living Sitting Time in Middle-Age and Older Adults

Supplemental digital content is available in the text. ABSTRACT National guidelines recommend physically active interruptions to sitting time; however, the characteristics of these interruptions are broadly stated and ill-defined. A robust methodology for population surveillance for such interruptions is needed. Purpose To describe the frequency and characteristics (i.e., duration, stepping time, and estimated intensity) of all interruptions and physically active interruptions to adults’ free-living sitting time (i.e., transitions from sitting to upright posture) across segments of the population. Methods Australian Diabetes, Obesity and Lifestyle study participants (321 men; 406 women; mean ± standard deviation, 58.0 ± 10.3 yr) wore the activPAL3™ for ≥1 valid day. The characteristics of interruptions from laboratory studies demonstrating health benefits were selected to define active interruptions (≥5 min upright and/or ≥2 min stepping) and ambulatory interruptions (≥2 min stepping). The frequency and characteristics of all, active, and ambulatory interruptions were described and compared by age, sex, diabetes status, and body mass index. Results Adults averaged 55.0 ± 21.8 interruptions per day, but only 20.3 ± 6.7 were active and 14.0 ± 5.4 were ambulatory. Median (25th, 75th percentile) duration was 2.6 min (0.9, 7.8 min), stepping time was 0.8 min (0.3, 2.0 min), and estimated energy expenditure was 4.3 metabolic equivalents (MET)·min−1 (1.4, 12.5 MET·min−1). Those who were older, had obesity, or had diabetes had significantly (P < 0.05) fewer interruptions of all types and less stepping time during active interruptions than their counterparts (Cohen’s d < 0.2). Conclusions Free-living interruptions were often less active than interruptions performed in effective acute laboratory studies and their content varied widely between population groups. Monitoring all interruptions, as well as those that are more active, is advisable to provide a comprehensive understanding of free-living sedentary behavior.
Utility of the Loop-Mediated Isothermal Amplification Assay for the Diagnosis of Visceral Leishmaniasis from Blood Samples in Ethiopia

ABSTRACT. Rapid and accurate diagnosis of visceral leishmaniasis (VL) is needed to initiate prompt treatment to reduce morbidity and mortality. Here, we evaluated the performance of loop-mediated isothermal amplification (LAMP) assay for the diagnosis of VL from blood in an endemic area in Ethiopia. LAMP was positive in 117/122 confirmed VL cases and negative in 149/152 controls, resulting in a sensitivity of 95.9% (95% CI: 90.69–98.66) and a specificity of 98.0% (95% CI: 94.34–99.59), respectively. The sensitivity of the LAMP assay was 95.0% (95% CI: 88.61–98.34) in HIV-negatives and 100% (95% CI: 85.18–100.0) in HIV-positives. Compared with microscopy, LAMP detected 82/87 (94.3%, 95% CI: 87.10–98.11) of the microscopy+ cases and was negative in 11/27 (40.7%, 95% CI: 22.39–61.20) of the microscopy− cases. Compared with the rK39 serology, LAMP detected 113/120 (94.2%, 95% CI: 88.35–97.62) of the rK39+ cases and was negative in 149/154 (96.8%, 95% CI: 92.59–98.94) of the rK39− cases. However, when compared with microscopy only, rK39 detected 83/87 (95.4%, 95% CI: 88.64–98.73) of the microscopy+ cases and negative in only 12/27 (44.4%, 95% CI: 25.48–64.67) of the microscopy– cases. There was an excellent agreement between rK39 and LAMP (Kappa = 0.91, 95% CI: 0.86–0.96). Furthermore, an algorithm using rK39 followed by LAMP would yield a sensitivity of 99.2% (95%CI: 95.52–99.89) and a specificity of 98.0% (95% CI: 94.34–99.59). The findings demonstrate that LAMP assay is an accurate and rapid molecular assay for VL diagnosis, including in HIV-1 coinfected patients, in an endemic setting.
US Sick Leave In Global Context: US Eligibility Rules Widen Inequalities Despite Readily Available Solutions.

Research has demonstrated that paid sick leave reduces spread of COVID-19 and other infectious diseases and improves preventive care and access to treatment across a wide range of conditions. However, the U.S. has no national paid sick leave policy, and even unpaid FMLA leave-often viewed as a foundation for new paid leave legislation-is often inaccessible. We analyzed a nationally representative survey to determine the extent to which specific FMLA features produce gaps and disparities in leave access. We then use comparative policy data from 193 countries to analyze whether these policy features are necessary or prevalent globally, or whether there are common alternatives. We found that the FMLA's minimum hours requirement disproportionately excludes women, while its tenure requirement disproportionately excludes Black, Indigenous, and multiracial workers. Latinx workers face greater exclusion due to employer size. Of the 94% of countries that provide permanent paid sick leave, none broadly restrict leave based on employer size and 93% cover part-time workers without a minimum hour requirement. Enacting permanent paid sick leave accessible regardless of employer size, tenure, or hours is critical and feasible. [Editor's Note: This Fast Track Ahead Of Print article is the accepted version of the peer-reviewed manuscript. The final edited version will appear in an upcoming issue of Health Affairs. ].
The Association Between Plasma α-Synuclein (α-syn) Protein, Urinary Alzheimer-Associated Neuronal Thread Protein (AD7c-NTP), and Apolipoprotein Epsilon 4 (ApoE ɛ4) Alleles and Cognitive Decline in 60 Patients with Alzheimer’s Disease Compared with 28 Age-Matched Normal Individuals

Background Accumulating evidence has shown that α-synuclein (α-syn) pathology is involved in the pathophysiology of Alzheimer’s disease (AD). This study aimed to investigate the association between the levels of plasma α-syn protein, urinary Alzheimer-associated neuronal thread protein (AD7c-NTP), apolipoprotein epsilon 4 (ApoE ɛ4) alleles and cognitive decline in 60 AD patients compared with 28 age-matched normal controls (NCs) at a single center. Material/Methods All participants underwent α-syn, apolipoprotein E (ApoE), AD7c-NTP, cholesterol (CHO), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides (TGs) analyses, neuropsychological scale assessments and neuroimaging analysis. Moreover, urine and peripheral blood samples were collected from all participants. The levels of plasma α-syn and AD7c-NTP were assayed using an enzyme-linked immunosorbent assay (ELISA) kit. Other test results were obtained from China-Japan Friendship Hospital. Results We found that plasma α-syn levels were significantly different between AD patients and NCs (p=0.045). α-Syn levels were also associated with AD7c-NTP (r=0.231, p=0.03) but not ApoE ɛ4 (Z=−0.147, p=0.883) levels. Neither α-syn [CHO (p=0.432), HDL (p=0.484), LDL (p=0.733) or TGs (p=0.253)] nor AD7c-NTP [CHO (p=0.867), HDL (p=0.13), LDL (p=0.57) or TGs (p=0.678)] had a relationship with lipids. Conclusions This study showed that the levels of plasma α-syn protein and urinary AD7c-NTP were significantly increased in AD patients compared with NCs, but not with ApoE alleles or serum lipid levels.
Can we afford to ignore the biology of joint healing and graft incorporation after ACL reconstruction?

Anterior cruciate ligament (ACL) reconstruction is successful at restoring stability to return ACL injured patients to high‐demand work, sports, and recreational activities. The development of posttraumatic osteoarthritis (OA) in roughly half of patients just 10–15 years after ACLR highlight the need to improve clinical care pathways. Graft failure and reinjury rates, which further increase OA risk, also remain high for younger and more active patients. The biological components of joint recovery and graft incorporation, therefore, impact short‐ and long‐term clinical outcomes. Biochemical and magnetic resonance imaging (MRI) data show substantial compromise of articular cartilage metabolism and matrix composition after ACL injury and reconstructive surgery suggesting a potential need for activity modulation in early recovery. Furthermore, joint recovery is variable with compositional MRI studies showing progressive cartilage degeneration 1 and 2 years after ACLR. Biopsy and MRI studies also show high variability in ACL graft characteristics within the 1st year after ACLR followed by continued graft maturation into the 2nd year and beyond. To improve the care of ACL injured patients, there is a critical need for clinical attention and scientific inquiry into timing the reintroduction of higher load activities in relationship to neuromuscular recovery, joint biology, and graft maturation. In addition to symptomatic and mechanical recovery, development and validation of biological markers for joint and cartilage homeostasis as well as ACL graft healing are needed for personalized decision making on rehabilitation needs, reduction of OA risk, and resumption of athletic, recreational, and vocational activities.
Urinary soluble (pro)renin receptor excretion is associated with urine pH in humans

The (pro)renin receptor [(P)RR] binds to renin and its precursor prorenin to activate the tissue renin-angiotensin system. It is cleaved to generate soluble (P)RR and M8–9, a residual hydrophobic truncated protein. The (pro)renin receptor also functions as an intracellular accessory protein of vacuolar-type H+-ATPase, which plays an essential role in controlling the intracellular vesicular acid environment. Thus, in the kidney, (P)RR may play a role in transporting H+ to urine in the collecting duct. Although blood soluble (P)RR has been recognized as a biomarker reflecting the status of the tissue renin-angiotensin system and/or tissue (P)RR, the significance of urinary soluble (P)RR excretion has not been determined. Therefore, this study aimed to investigate the characteristics of urinary soluble (P)RR excretion. Urinary soluble (P)RR excretion was measured, and its association with background factors was investigated in 441 patients. Relationships between changes in urine pH due to vitamin C treatment, which reduce urine pH, and urinary soluble (P)RR excretion were investigated in 10 healthy volunteers. Urinary soluble (P)RR excretion was 1.46 (0.44–2.92) ng/gCre. Urine pH showed a significantly positive association with urinary soluble (P)RR excretion, independent of other factors. Changes in urine pH and urinary soluble (P)RR excretion due to vitamin C treatment were significantly and positively correlated (ρ = 0.8182, p = 0.0038). These data showed an association between urinary soluble (P)RR excretion and urine pH in humans, suggesting that (P)RR in the kidney might play a role in urine pH regulation.
RBCK1‐TRIB3 decelerated the progression of acute promyelocytic leukemia

Under the differentiation induction therapy with all‐trans retinoic acid and arsenic trioxide, nearly 95% of typical acute promyelocyte leukemia (APL), which is characterized by the presence of PML‐RARA, patients can be cured. Though its good prognosis, if left untreated, the natural survival duration of typical APL patients is only 1 month, but some exceptional cases also exist. Occasionally, we have observed the entire natural clinical course of one extremely indolent APL patient, who developed from pre‐APL stage (<20% promyelocytes in bone marrow) to overt‐APL stage (≥20% promyelocytes in bone marrow) with one nearly 2‐year latency. Strikingly, we identified one novel fusion RBCK1‐TRIB3 in the pre‐APL stage but not overt‐APL stage sample. It has been reported that TRIB3 stabilized PML‐RARA to driver APL progression, while RBCK1‐TRIB3 partially disrupted TRIB3WT expression, so it contributed to the deceleration of APL progression in this patient.
The transcription factor PagLBD3 contributes to the regulation of secondary growth in Populus.

LATERAL ORGAN BOUNDARIES DOMAIN (LBD) genes encode plant-specific transcription factors that participate in regulating various developmental processes. In this study, we genetically characterized PagLBD3 as an important regulator of secondary growth in Populus. Overexpression of PagLBD3 increased stem secondary growth in Populus with significantly higher rate of cambial cells differentiated into phloem, while dominant repression of PagLBD3 significantly decreased the rate of cambial cells differentiated into phloem. Furthermore, we identified 1756 PagLBD3 genome-wide putative direct target genes (DTGs) through RNA sequencing (RNA-seq) coupled DNA affinity purification followed by sequencing (DAP-seq) assays. Gene Ontology analysis revealed that genes regulated by PagLBD3 were enriched in biological pathways regulating meristem development, xylem development, and auxin transport. Several central regulator genes for vascular development, including PHLOEM INTERCALATED WITH XYLEM (PXY), WUSCHEL RELATED HOMEOBOX4 (WOX4), Secondary Wall-Associated NAC Domain 1s (SND1-B2) and Vascular-Related NAC-Domain 6s (VND6-B1), were identified as PagLBD3 DTGs. Together, our results suggested that PagLBD3 and its DTGs form a complex transcriptional network to modulate cambium activity and phloem/xylem differentiation.
Effects of Social Determinants of Health Care on Pediatric Thyroid Cancer Outcomes in the United States

Objective To identify social determinants of health care that are associated with poorer pediatric well-differentiated thyroid cancer (WDTC) outcomes and increased stage at presentation. Study Design Using the SEER database (Surveillance, Epidemiology, and End Results), we retrospectively gathered data on pediatric WDTC across the United States between 1973 and 2015. Setting All patients between 0 and 19 years old with a diagnosis of WDTC were included. Methods Patient variables were analyzed for relationships to AJCC stage at presentation (American Joint Committee on Cancer), overall survival, and disease-specific survival. Results Among 3913 patients with pediatric thyroid cancer, 3185 were female (81.4%), 3366 had papillary thyroid cancer (85.3%), and 367 had follicular thyroid cancer (9.4%). Two- and 5-year overall and disease-specific survival approached 100%. However, when outcomes were analyzed by specific populations, male sex, non-Caucasian race, poverty, and language isolation were linked to worse overall survival. Male sex and poverty were associated with poorer disease-specific survival. Regarding overall AJCC stage at presentation, male sex and Black race were related to higher overall presenting AJCC stage. Later AJCC T stage at presentation was seen in male, Hispanic, Asian, and Black patients. There were no variables significantly related to following through with recommended surgery. Conclusion Pediatric WDTC continues to carry an excellent prognosis in the United States. However, when we consider specific populations, the social determinants of health care affect survival and disease burden at presentation: male sex, poverty, language isolation, and race affected survival and/or AJCC stage at presentation in pediatric WDTC.
A functional analysis reveals extremely low redundancy in global mangrove invertebrate fauna

Significance Global mangrove deforestation and degradation drive the loss of the associated invertebrate fauna vital to ecosystem services. The functional diversity and resilience of this fauna has not been assessed. We show that even small mangrove patches host functionally diverse faunal assemblages and can act as biodiversity reservoirs. However, globally, functional redundancy of mangrove invertebrates (i.e., the average number of species performing a similar functional role in an assemblage) is extremely low, except in Southeast Asia. Thus, even a modest local loss of invertebrate diversity will have significant negative consequences for mangrove functionality and resilience. Current approaches to assess threats to mangroves heavily rely on loss in areal extent, but our results suggest that loss of function may be more vulnerable. Deforestation results in habitat fragmentation, decreasing diversity, and functional degradation. For mangroves, no data are available on the impact of deforestation on the diversity and functionality of the specialized invertebrate fauna, critical for their functioning. We compiled a global dataset of mangrove invertebrate fauna comprising 364 species from 16 locations, classified into 64 functional entities (FEs). For each location, we calculated taxonomic distinctness (Δ+), functional richness (FRi), functional redundancy (FRe), and functional vulnerability (FVu) to assess functional integrity. Δ+ and FRi were significantly related to air temperature but not to geomorphic characteristics, mirroring the global biodiversity anomaly of mangrove trees. Neither of those two indices was linked to forest area, but both sharply decreased in human-impacted mangroves. About 60% of the locations showed an average FRe < 2, indicating that most of the FEs comprised one species only. Notable exceptions were the Eastern Indian Ocean and west Pacific Ocean locations, but also in this region, 57% of the FEs had no redundancy, placing mangroves among the most vulnerable ecosystems on the planet. Our study shows that despite low redundancy, even small mangrove patches host truly multifunctional faunal assemblages, ultimately underpinning their services. However, our analyses also suggest that even a modest local loss of invertebrate diversity could have significant negative consequences for many mangroves and cascading effects for adjacent ecosystems. This pattern of faunal-mediated ecosystem functionality is crucial for assessing the vulnerability of mangrove forests to anthropogenic impact and provides an approach to planning their effective conservation and restoration.