Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy of Sequential Capecitabine on Adjuvant Chemotherapy of Triple-Negative Breast Cancer

This paper aims to evaluate the efficacy of capecitabine as extended adjuvant treatment after anthracycline and paclitaxel combined adjuvant chemotherapy for women with early triple-negative breast cancer (TNBC). The patients with early TNBC were randomly assigned to capecitabine sequential treatment for 4 cycles and without any sequential treatment in the control group after anthracycline and paclitaxel combined adjuvant chemotherapy. The primary end point was disease-free survival (DFS). The secondary end point was overall survival (OS). One hundred patients were enrolled in this study between June 2013 and February 2015. Median age was 49 years ranging from 25 to 66 years and treatment was well tolerance. The median follow-up time after random allocation was 58 months (range: 11–62 months). There was no significant difference in DFS and OS between the two groups (hazard ratio (HR) of DFS was 0.50; 95% CI, 0.24–1.05; P=0.066). Our study shows that although the addition of four cycles capecitabine after anthracycline and paclitaxel combining adjuvant chemotherapy does not improve DFS and OS, but the trend of DFS is improved. The possible reason is that the four-cycle treatment of capecitabine is not enough, and another possible reason is that the number of cases is not enough.
PowderMEMS—A Generic Microfabrication Technology for Integrated Three-Dimensional Functional Microstructures

A comprehensive overview of PowderMEMS—a novel back-end-of-line-compatible microfabrication technology—is presented in this paper. The PowderMEMS process solidifies micron-sized particles via atomic layer deposition (ALD) to create three-dimensional microstructures on planar substrates from a wide variety of materials. The process offers numerous degrees of freedom for the design of functional MEMSs, such as a wide choice of different material properties and the precise definition of 3D volumes at the substrate level, with a defined degree of porosity. This work details the characteristics of PowderMEMS materials as well as the maturity of the fabrication technology, while highlighting prospects for future microdevices. Applications of PowderMEMS in the fields of magnetic, thermal, optical, fluidic, and electrochemical MEMSs are described, and future developments and challenges of the technology are discussed.
Distinct Functional Alterations and Therapeutic Options of Two Pathological De Novo Variants of the T292 Residue of GABRA1 Identified in Children with Epileptic Encephalopathy and Neurodevelopmental Disorders

Mutations of GABAAR have reportedly led to epileptic encephalopathy and neurodevelopmental disorders. We have identified a novel de novo T292S missense variant of GABRA1 from a pediatric patient with grievous global developmental delay but without obvious epileptic activity. This mutation coincidentally occurs at the same residue as that of a previously reported GABRA1 variant T292I identified from a pediatric patient with severe epilepsy. The distinct phenotypes of these two patients prompted us to compare the impacts of the two mutants on the receptor function and to search for suitable therapeutics. In this study, we used biochemical techniques and patch-clamp recordings in HEK293 cells overexpressing either wild-type or mutated rat recombinant GABAARs. We found that the α1T292S variant significantly increased GABA-evoked whole-cell currents, shifting the dose–response curve to the left without altering the maximal response. In contrast, the α1T292I variant significantly reduced GABA-evoked currents, shifting the dose–response curve to the right with a severely diminished maximum response. Single-channel recordings further revealed that the α1T292S variant increased, while the α1T292I variant decreased the GABAAR single-channel open time and open probability. Importantly, we found that the T292S mutation-induced increase in GABAAR function could be fully normalized by the negative GABAAR modulator thiocolchicoside, whereas the T292I mutation-induced impairment of GABAAR function was largely rescued with a combination of the GABAAR positive modulators diazepam and verapamil. Our study demonstrated that α1T292 is a critical residue for controlling GABAAR channel gating, and mutations at this residue may produce opposite impacts on the function of the receptors. Thus, the present work highlights the importance of functionally characterizing each individual GABAAR mutation for ensuring precision medicine.
The Partnership Model for The Diploma of Fashion Designer and The Fashion Industry

This study aims to describe the partnership model for the diploma of fashion design and fashion industry, which has already been implemented, and describe the partnership model needed. Data is collected by interview, observation, and documentation. The results show that the partnership between the diploma of fashion design and the fashion industry is mutually beneficial in terms of providing labor for the fashion industry and real work practices for the fashion design diploma. The partnership model that is needed is persuading the practice of fashion design and clothing production carried out in the industry, with the lecture model carried out in the one-month study program and the one-month industry, learning outcomes are assessed by the industry. Internships for lecturers are held every year for one month. Fieldwork practices include design, clothing production, pattern maker, and business management. Student selfdevelopment ahead of graduation, following fashion activities in the fashion community.
Damage Identification of Frame Structure Based on Approximate Metropolis–Hastings Algorithm and Probability Density Evolution Method

This paper proposes a new method to identify local damages in frame structures based on approximate Metropolis–Hastings (AMH) algorithm and statistical moment. By analyzing the sensitivity of different statistical moment-based damage indices, the fusion index of fourth-order displacement moment and eighth-order acceleration moment is selected. Then the local damages in frame structures are primarily evaluated by AMH algorithm, where Gibbs sampling is adopted. Finally, the uncertainty of identified local damages is analyzed by using probability density evolution method (PDEM). Numerical simulations have been conducted to compare the proposed method with other similar damage detection methods, showing that the proposed method is more time-saving due to the involvement of Gibbs sampling and more accurate in assessing the damage severity. Experimental study of a 12-story benchmark frame testing has also been carried out, further validating the effectiveness of the proposed method.
Mobile Design Pattern Gallery: UI Patterns for Smartphone Apps

When youre under pressure to produce a well-designed, easy-to-navigate mobile app, theres no time to reinvent the wheeland no need to. This handy reference provides more than 90 mobile app design patterns, illustrated by 1,000 screenshots from current Android, iOS, and Windows Phone apps. Much has changed since this books first edition. Mobile OSes have become increasingly different, driving their own design conventions and patterns, and many designers have embraced mobile-centric thinking. In this edition, user experience professional Theresa Neil walks product managers, designers, and developers through design patterns in 11 categories: Navigation: get patterns for primary and secondary navigation Forms: break industry-wide habits of bad form design Tables: display only the most important information Search, sort, and filter: make these functions easy to use Tools: create the illusion of direct interaction Charts: learn best practices for basic chart design Tutorials & Invitations: invite users to get started and discover features Social: help users connect and become part of the group Feedback & Accordance: provide users with timely feedback Help: integrate help pages into a smaller form factor Anti-Patterns: what not to do when designing a mobile app
Effect of the Consumption of Alcohol-Free Beers with Different Carbohydrate Composition on Postprandial Metabolic Response

Background: We investigated the postprandial effects of an alcohol-free beer with modified carbohydrate (CH) composition compared to regular alcohol-free beer. Methods: Two randomized crossover studies were conducted. In the first study, 10 healthy volunteers received 25 g of CH in four different periods, coming from regular alcohol-free beer (RB), alcohol-free beer enriched with isomaltulose and a resistant maltodextrin (IMB), alcohol-free beer enriched with resistant maltodextrin (MB), and a glucose-based beverage. In the second study, 20 healthy volunteers were provided with 50 g of CH from white bread (WB) plus water, or with 14.3 g of CH coming from RB, IMB, MB, and extra WB. Blood was sampled after ingestion every 15 min for 2 h. Glucose, insulin, incretin hormones, TG, and NEFAs were determined in all samples. Results: The increase in glucose, insulin, and incretin hormones after the consumption of IMB and MB was significantly lower than after RB. The consumption of WB with IMB and MB showed significantly less increase in glucose levels than WB with water or WB with RB. Conclusions: The consumption of an alcohol-free beer with modified CH composition led to a better postprandial response compared to a conventional alcohol-free beer.
Effects of lidar coverage and field plot data numerosity on forest growing stock volume estimation

ABSTRACT Forest parameter estimation is required to support the sustainable management of forest ecosystems. Currently, forest resource assessment is increasingly linked to auxiliary information obtained from remote sensing (RS) technologies. In forest parameter estimation, airborne laser scanning (ALS) data have been demonstrated to be an invaluable source of information. However, ALS data are often not available for the entire forest area, whereas images from multiple satellite systems offer new opportunities for large-scale forest surveys. This study aims to assess and estimate the contribution of field plot data and ALS data along with Landsat data to the precision of growing stock volume (GSV) estimates. We compared different approaches for model-assisted estimation of mean forest GSV per unit area using different proportions of field sample data, ALS cover data, and wall-to-wall Landsat data. Model-assisted estimators were used with NFI sample data in an Italian study area using 10 RS predictors, specifically the seven Landsat 7 ETM+ bands and three fine-resolution metrics based on ALS-derived canopy height. We found that relative to the standard simple expansion estimator, the model-assisted estimators produced relative efficiency of 1.16 when using only Landsat data and relative efficiencies as great as 1.33 when using increasing levels of ALS coverage.
A Survey on Evolutionary Constrained Multiobjective Optimization

Handling constrained multiobjective optimization problems (CMOPs) is extremely challenging, since multiple conflicting objectives subject to various constraints require to be simultaneously optimized. To deal with CMOPs, numerous constrained multiobjective evolutionary algorithms (CMOEAs) have been proposed in recent years, and they have achieved promising performance. However, there has been few literature on the systematic review of the related studies currently. This article provides a comprehensive survey for evolutionary constrained multiobjective optimization. We first review a large number of CMOEAs through categorization and analyze their advantages and drawbacks in each category. Then, we summarize the benchmark test problems and investigate the performance of different constraint handling techniques (CHTs) and different algorithms, followed by some emerging and representative applications of CMOEAs. Finally, we discuss some new challenges and point out some directions of the future research in the field of evolutionary constrained multiobjective optimization.
The Properties of Linear Low Density Polyethylene/Cyperus Odoratus (LLDPE/CY) Blends: Effect of Sodium Hydroxide

The purpose of this study was to determine the effect of treated Cyperus Odoratus (CY) with sodium hydroxide (NaOH) on the properties of biodegradable plastics made from linear low density polyethylene (LLDPE)/CY blends. Alkali treatments for natural fibers can increased adhesion between the hydrophilic fibers and hydrophobic matric. After CY was treated with 5% NaOH solution, it can be seen that the tensile strength and Young’s modulus of the LLDPE/CY blends significantly increased. Therefore, alkali treatments can be considered in modifying the properties of natural fibers.
Outcomes of Ewing sarcoma in adults over 40 years of age from a low-middle income country

Introduction The data on outcomes and toxicity in adult Ewing sarcoma (ES) patients, particularly those aged ≥40 years, is exceedingly scarce around the world, particularly in low- and middle-income countries (LMICs) and mandates research. Methods The study involved histologically ascertained ES patients aged ≥40 years who registered at our institute from 2013 to 2018. Prospectively collected data were analysed for overall survival (OS), event-free survival (EFS) and chemotherapy-related toxicities. Results There were 66 patients, of which 34 were non-metastatic, and 32 were denovo metastatic, recurrent or had doubtful metastasis. At presentation, median age was 46 years, and 42 (63.6%) had extra-skeletal primary and 24 (36.3%) had extremity tumours. Curative treatment was offered to 40 (60.6%) patients. Significant grade 3/4 toxicities in non-metastatic and metastatic cohort, respectively, were febrile neutropenia (61.3%, 37.5%), anaemia (58.1%, 37.5%), thrombocytopenia (45.2%, 25.0%), peripheral neuropathy (25.8%, 12.5%) and dyselectrolytemia (25.8%, 6.25%). Chemotherapy-related toxicity led to death in three patients in the metastatic cohort, versus none in the non-metastatic patients. The 5 year EFS and OS for non-metastatic cohort were 53.8% and 67.8%, while the same for metastatic cohort were 20.7% and 27.5%, respectively. On multivariate analysis, Eastern Cooperative Oncology Group-performance status >2 and metastasis at presentation predicted poorer EFS and OS. Additionally, raised lactate dehydrogenase, larger tumours (>8 cm) and palliative intent treatment predicted worse EFS, while extra-skeletal primary and female gender were indicators of worse OS. Conclusions Older adult ES patients benefit from aggressive multimodality treatment even in LMIC infrastructure. However, careful patient selection, close monitoring and pertinent dose modifications is imperative due to higher propensity for potential toxicities.
Evolution of customer satisfaction in the e-banking service industry

Since several commercial activities such as banking, shopping, transfers, and payments had been conducted online, many banks in Cambodia provided e-banking services to their customers to support these activities. Meanwhile, if the banks could provide such e-banking services to satisfy their customers’ needs, they could maintain their customers and profits. Thus, finding the main factors influencing customer satisfaction in the e-banking service industry is significant. Therefore, the objective of this paper is to investigate how customer satisfaction develops through examining the impacts of perceived risk (financial risk and performance risk) and perceived value on customer satisfaction in the e-banking. This study applied convenience sampling to get data from the respondents at convenient locations (near banks, markets, supermarkets, universities, and workplaces). 700 respondents who were currently using mobile banking or internet banking services at either commercial or retail banks in Cambodia were invited to fill in the questionnaires. In addition, the results of this study were generated through structural equation model (SEM) analysis based on 546 valid responses. The results revealed that perceived value was mainly influenced by performance risk, whereas financial risk did not significantly affect perceived value. Finally, perceived value and performance risk significantly influenced customer satisfaction, except financial risk. In addition, despite both perceived value and performance risk significantly influencing customer satisfaction, promoting customer satisfaction through increasing perceived value was far more effective than minimizing performance risk.
Multiple-Models Adaptive Disturbance Observer-Based Predictive Control for Linear Permanent-Magnet Synchronous Motor Vector Drive

To achieve high-performance control of the precise linear permanent-magnet synchronous motor (LPMSM) control system, a composite robust current regulation method with good dynamic response and disturbance rejection performance is proposed. First, a continuous time model predictive current control is utilized to obtain superior current response. Since the predictive current control has a strong dependence on the precise mathematical model of the controlled plant, there will be static current error and even system instability when model mismatch and parameter variation. Then, aiming at this problem, the adaptive disturbance observer is applied to compensate the lumped disturbance. However, the adaptive disturbance observer designed based on the single model adaptive law has some disadvantages, such as low precision, long regulation time, poor transient response, and so on. Consequently, a multiple-models adaptive disturbance observer is proposed, which improves the convergence speed of disturbance estimation and system's robustness against parameter perturbation and model mismatch. Finally, a 0.9-kW LPMSM is used as a case study, and the experimental results show the effectiveness of the proposed solution, both during the transient and steady-state operating conditions.
LONGITUDINAL DYNAMICS OF INTENSE HEAVY-ION BUNCHES IN SIS-100

In the SIS-100 highest heavy ion intensities have to be accelerated to deliver beam to the FAIR experiments. In the projected SIS-100 synchrotron the heavy ion bunches will be strongly affected by the longitudinal space charge force. Due to the limited RF bucket area all mechanisms which might cause longitudinal phase space dilution must be understoodandcontrolled. Space chargeeffects, like the reduction in the RF voltage and the loss of Landau damping, have already been part of elaborate studies. It has been shown that cavity beam loading can deform the flattened bunch shape in the dual RF bucket. Among the different counter measures an inductive insert has been proposed in order to partially compensate the longitudinal space charge impedance. Optimized settings for the difference between the two RF phases in a dual RF bucket might be an option to reduce the effect of beam loading. In this contribution we will analyse the matched bunch distribution for SIS100 parameters in single and dual RF buckets. Analytical and numerical studies of the interplay of longitudinal space charge, cavity beam loading and an inductive insert will be presented.
EFFECT OF SPEED-GOVERNOR DEADBAND ON AGC ANALYSIS FOR TWO AREAS THERMAL-THERMAL SYSTEM

Thermal system is present in this paper. The governor deadband nonlinearity is included in the analysis. The model by just changing the controllers can be used to study the response with and without governor deadband. It is shown that the governor deadband nonlinearity has a destabilizing effect on the transient response with deterministic load disturbance. It is found that the proportional integral controller reduces the over shoot and leaves the setting time unchanged with respect to case when using integral controller. It is found that the value of B has an important influence on the transient behavior of AGC.
A Wideband Reconfigurable CMOS VGA Based on an Asymmetric Capacitor Technique with a Low Phase Variation

This paper presents a wideband digitally controlled variable gain amplifier (VGA) with a reconfigurable gain tuning range and gain step in a 65 nm CMOS process. A unique asymmetric capacitor-based reconfigurable technique is proposed to extend the gain tuning range and realize gain step reconfiguration. An active neutralization topology based on a stackless transistor is utilized to compensate for the additional phase shift introduced by the gain tuning. Moreover, a current-type digital-to-analog converter (DAC) is also integrated for easier precise gain control. With the asymmetric capacitor varying from 1000 fF to 200 fF with a step of 400 fF, the proposed VGA achieves a 12.2/9.2/6.1 dB gain tuning range with a 0.4/0.3/0.2 dB gain resolution, respectively. At the maximum gain tuning range mode, the measured minimum root-mean-square (RMS) phase error is 1.7° at 23.4 GHz. At the finest gain step control mode, the RMS phase error measured across 20–30 GHz is lower than 1.9°. The tested result also shows the proposed VGA achieves a peak gain of 13 dB with a 3 dB bandwidth of 21.4–29 GHz, and the output 1 dB compression point (OP1dB) is up to 8.6 dBm at 25 GHz.
Estimating the Diagnostic Accuracy of High Sensitive C- Reactive Protein (hs-CRP) in Early Detection of Neonatal Sepsis

Background: Neonatal sepsis is a critical issue and if sepsis in neonates is diagnosed early by reliable tests, we can avoid unwanted administration of higher antibiotics, reduce the expenses of hospital care and also prevent emergence of bacterial strains that are resistance to antibiotics. Detecting neonatal sepsis in its earlier stage is still difficult as it presents as a variety of symptoms that could also classify many other disorders. Early onset sepsis presents within 72 hours of birth. This study aims to measure the efficacy of high sensitive CRP (hs-CRP) in early diagnosis of neonatal sepsis. Methodology: This prospective cross sectional study will be conducted at AVBRH, Wardha. Two serial measurements of hs-CRP will be taken and values will be correlated with respect to other conventional screening markers. CRP and hs-CRP levels in these populations will be studied and compared to assess sensitivity, specificity and observed cut off values for the same. The neonates will be followed up during hospital stay till discharge and outcome will be noted and all data will be collected. Data analysis will be done at the end using appropriate statistical methods. Expected Results: In our study we expect hs-CRP to be more sensitive in predicting neonatal sepsis as compared to conventional markers like CRP, Septic screen. We expect hs-CRP to be a better predictor in diagnosing sepsis so that we can intervene early and reduce morbidity and hospital stay. Conclusion: Inclusion of hs-CRP as part of routine screening of neonates for sepsis can be recommended.
Transcription-coupled DNA repair underlies variation in persister awakening and the emergence of resistance

Persisters constitute a population of temporarily antibiotic-tolerant variants in an isogenic bacterial population and are considered an important cause of relapsing infections. It is currently unclear how cellular damage inflicted by antibiotic action is reversed upon persister state exit and how this relates to antibiotic resistance development. We demonstrate that persisters, upon fluoroquinolone treatment, accumulate oxidative damage which is repaired through nucleotide excision repair. Detection of the damage occurs via transcription-coupled repair using UvrD-mediated backtracking or Mfd-mediated displacement of the RNA polymerase. This competition results in heterogeneity in persister awakening lags. Most persisters repair the oxidative DNA damage, displaying a mutation rate equal to the untreated population. However, the promutagenic factor Mfd increases the mutation rate in a persister subpopulation. Our data provide in-depth insight in the molecular mechanisms underlying persister survival and pinpoints Mfd as an important molecular factor linking persistence to resistance development.