Miracle-dz/UniFAR-FTUs huggingface dataset:
Jurassic and Cretaceous Radiolarians from the pre-Tertiary System in the Hidaka Belt, Maruseppu Region, Northeast Hokkaido

We have made a study of the pre-Teniary H idaka Supcrgroup (the Kanayama Formation), which is dis­ tribUlcd at thc most castcrl y ponion of thc Hidaka Be lt , in order to ascertain the age of accumulation of this supergroup. The Kanaya ma Formation con sists mainly of broken formations in which clastic rock s of tcr­ rigenous origin prcdominatc and man y exo ti c block s arc included in th e scaly shale matrix. The tuffaceous shale of thi s format ion yielded Ampliipyndox ly/OIUS - C/orlirocyc/os diceros radiolari an assemblagc which indicates late Campania n to early Maastricht ian age. And a late Jurassic Srylocopso (? ) spiralis and carl y C retaceou s Serliocopso Irocliyosrroco - Srourosplioero seprempororus assemblages were obtained from chert bl ock within the mela nge fac ies o f [he Kanayama Format ion. This format ion may represent a part o f accre­ ti onary complex formed by subduct ion process du ring the lale Cretaceou s.
The Methyltransferase NSD3 Has Chromatin-binding Motifs, PHD5-C5HCH, That Are Distinct from Other NSD (Nuclear Receptor SET Domain) Family Members in Their Histone H3 Recognition*

Background: NSD proteins are histone H3K36 methyltransferases linked to multiple human diseases. Results: Crystal structures of chromatin-binding motifs, PHD5-C5HCH, of NSD3 bound to the H3 N-terminal peptide were solved. Conclusion: PHD5-C5HCHs of the NSD family are conserved in their overall structure yet variant in H3 recognition. Significance: Their variant recognitions may play a role in the localization of NSD proteins to different genomic sites. The NSD (nuclear receptor SET domain-containing) family members, consisting of NSD1, NSD2 (MMSET/WHSC1), and NSD3 (WHSC1L1), are SET domain-containing methyltransferases and aberrant expression of each member has been implicated in multiple diseases. They have specific mono- and dimethylase activities for H3K36, whereas play nonredundant roles during development. Aside from the well characterized catalytic SET domain, NSD proteins have multiple potential chromatin-binding motifs that are clinically relevant, including the fifth plant homeodomain (PHD5) and the adjacent Cys-His-rich domain (C5HCH) located at the C terminus. Herein, we report the crystal structures of the PHD5-C5HCH module of NSD3, in the free state and in complex with H31–7 (H3 residues 1–7), H31–15 (H3 residues 1–15), and H31–15K9me3 (H3 residues 1–15 with trimethylation on K9) peptides. These structures reveal that the PHD5 and C5HCH domains fold into a novel integrated PHD-PHD-like structural module with H3 peptide bound only on the surface of PHD5 and provide the molecular basis for the recognition of unmodified H3K4 and trimethylated H3K9 by NSD3 PHD5. Structural studies and binding assays show that differences exist in histone binding specificity of the PHD5 domain between three members of the NSD family. For NSD2, the PHD5-C5HCH:H3 N terminus interaction is largely conserved, although with a stronger preference for unmethylated H3K9 (H3K9me0) than trimethylated H3K9 (H3K9me3), and NSD1 PHD5-C5HCH does not bind to H3 peptides. Our results shed light on how NSD proteins that mediate H3K36 methylation are localized to specific genomic sites and provide implications for the mechanism of functional diversity of NSD proteins.
Running Head: Abuse and educational achievement Exposure to childhood sexual and physical abuse and subsequent educational achievement

Objective: This paper examined the relationship between exposure to sexual and physical abuse (CSA and CPA) in childhood and later educational achievement outcomes in late adolescence and early adulthood in a birth cohort of over 1000 children studied to age 25. Method: Retrospective data on CSA and CPA were gathered at ages 18 and 21 and used to form a best estimate of exposure to CSA and CPA. The relationship between CSA, CPA, and self-reported educational outcomes to 25 years was examined using logistic regression models that took into account social background, parental factors, and individual factors. Results: Increasing exposure to CSA and CPA was significantly associated with failing to achieve secondary school qualifications (CSA: B = .53, SE = .13, p < .0001; CPA: B = .62, SE = .12, p < .0001), gaining a Higher School Certificate (CSA: B = -.48, SE = .13, p < .001; CPA: B = -.78, SE = .14, p < .001), attending university (CSA: B = -.29, SE = .13, p < .05; CPA: B = -.45, SE = .13, p < .001), and gaining a university degree (CSA: B = -.54, SE = .18, p < .005; CPA: B = -.64, SE = .17, p < .001). Adjustment for confounding social, parental, and individual factors explained most of these associations. After control for confounding factors, omnibus tests of the associations between CSA and outcomes and CPA and outcomes failed to reach statistical significance (CSA: Wald χ (4) = 7.72, p = . 10; CPA: Wald χ (4) = 8.26, p = . 08). Conclusions: The effects of exposure to CSA and CPA on later educational achievement outcomes are largely explained by the social, family, and individual context within which exposure to abuse
The cultural crisis of the firm

Acknowledgements. Part I. Competition, Time, and Space. 1. The End of an Industrial Era. 2. Competition, Time, and Space in Industrial Change. 3. The New Competition and the Recalibration of Time and Space. 4. The Sources of Industrial Rigidity. Part II. Corporate Culture, Strategy, and Change. 5. Corporate Culture and Strategy. 6. Culture, Identity, and Corporate Transformations: case Studies. Part III. The Cultural Crisis of the Firm. The Cultural Crisis of the Firm. Bibliography. Index
Fluoroquinolone-Associated Tendinopathy of the Hand and Wrist: A Systematic Review and Case Report

Background: Fluoroquinolone use has been known to be associated with tendinopathy and tendon rupture for over 30 years. Hand and wrist involvement has been reported rarely, yet without early recognition and withdrawal of the fluoroquinolone, there is potential for significant morbidity. Methods: We searched Medline using a comprehensive search strategy for fluoroquinolones and tendinopathy of the hand and wrist, and provide a case report of a possible levofloxacin-related tendon rupture in a patient with a previous mutilating hand injury. Results: We located 10 previously reported cases of fluoroquinolone-associated tendinopathy in the hand or wrist ranging from 1983 to 2015. Unlike Achilles tendinopathy, women were no more likely than men to have tendon rupture affecting the hands or wrists. Our patient was a 59-year-old man with prior tendon repair but otherwise noncontributory medical history who experienced spontaneous tendon rupture on an extended course of levofloxacin and required extensive pulley and boutonnière repair. Conclusions: Given the extensive damage that may be caused to weakened tissue, clinicians should maintain a high index of suspicion of tendinopathy in patients taking fluoroquinolones who have had previous tendon repairs, particularly in the setting of unexplained changes in recovery trajectory.
Forensic Chemistry of Alkaloids: Presumptive Color Test

Evidence collected from crime scenes often includes unknown powders, pills, and tablets, many of which are illicit drugs difficult to identify visually. Presumptive color tests help with the on-scene recognition of drug materials via rapid color changes. Most of these tests are based on qualitative chemical reactions and have since been standardized. Although simple and rapid, qualitative tests provide only preliminary analytical data. Nevertheless, these tests are still important components of crime scene investigations, and government authorities deploy them to detect illicit drugs in the field. Understanding the chemistry behind presumptive color tests makes it possible to predict reactions to known drug standards. However, in the presence of cutting agents and other chemicals, the results of presumptive color tests may not be predictable due, in part, to interference by contaminating chemicals. Most described presumptive tests are developed for ‘classic’ drugs, such as opiates, amphetamines, and cocaine, but new psycho-active substances and cutting agents emerge every day on the market. Among them, alkaloids (e.g., lobeline, caffeine, piperine) can be purchased easily and legally via the Internet or in local shops and are often utilized to lace or cut drugs. This study is the first to predict and document the results on 7 of the most common presumptive color tests with various alkaloid standards. We assessed these tests with mixtures of alkaloids to ascertain interference, if any, in the color results. We performed presumptive color tests on various popular cutting agents and, finally, tested several mixtures of drugs/alkaloids/cutting agents potentially similar to samples seized in the field. The results showed that color prediction worked well with pure standards, but color tests could not be predicted for mixtures in most cases. Also, alkaloid cutting agents often interfere with presumptive color test results, affecting outcomes. Better understanding of presumptive color tests, coupled with better populated databases of color results involving cutting agents, will help in reducing false positives and false negatives, thereby improving initial testing of seized evidence.
The relationship of anxiety and depression with self-reported knee pain in the community: data from the Baltimore Longitudinal Study of Aging.

OBJECTIVE To investigate the relationship between anxiety and depression and reporting of knee pain in the community. METHODS Subjects (n = 374) were community volunteers aged 40 years and above who are participants in the Baltimore Longitudinal Study of Aging, a prospective multidisciplinary research study of normative aging. Knee pain was defined by the First National Health and Nutrition Examination Survey question "have you ever had pain in or around your knee on most days for at least one month? "; anxiety and depression were measured by the relevant subscales of the Arthritis Impact Measurement Scales questionnaire. All subjects had standing anteroposterior radiographs, read for Kellgren and Lawrence (K + L) grade. RESULTS After adjustment for age, women reporting "ever" knee pain had significantly higher anxiety scores than those reporting "never" pain (3.06 +/- 0.26 versus 2.35 +/- 0.17; P = 0.025). Pain reporting was related neither to anxiety scores in men, nor to depression in either sex. Analysis stratified by radiographic severity, adjusted for age and gender, showed that differences in anxiety were confined to those reporting knee pain in the absence of radiographic change (i.e., K + L grade 0). CONCLUSIONS In the community, women reporting knee pain in the absence of radiographic osteoarthritis have higher anxiety scores than those without pain. Depression was not significantly related to knee pain in this population. Psychosocial factors may explain some of the discrepancy between reported knee pain and structural change as seen on x-ray.
What Drives Preventive Health Behavior During a Global Pandemic? Emotion and Worry

Abstract Background & Purpose Primary prevention of COVID-19 has focused on encouraging compliance with specific behaviors that restrict contagion. This investigation sought to characterize engagement in these behaviors in U.S. adults early during the pandemic and to build explanatory models of the psychological processes that drive them. Methods US adults were recruited through Qualtrics Research Panels (N = 324; 55% female; Mage = 50.91, SD = 15.98) and completed 10 days of online reports of emotion, COVID-19 perceived susceptibility and worry, and recommended behaviors (social distancing, hand washing, etc.). Factor analysis revealed behaviors loaded on two factors suggesting distinct motivational orientations: approach and avoidance. Results Changes in approach and avoidance behaviors over the 10 days indicated large individual differences consistent with three types of participants. Discrete emotions, including fear, guilt/shame, and happiness were associated with more recommended behaviors. Fear and COVID-19 worry indirectly influenced each other to facilitate more behavioral engagement. While emotions and worry strongly predicted individual differences in behavior across the 10 days, they did not predict as well why behaviors occurred on one day versus another. Conclusions These findings suggest how daily affective processes motivate behavior, improving the understanding of compliance and efforts to target behaviors as primary prevention of disease.
MINIREVIEW Vibrio vulniﬁcus : Disease and Pathogenesis (cid:1)

Vibrio vulniﬁcus is an opportunistic human pathogen that is highly lethal and is responsible for the overwhelming majority of reported seafood-related deaths in the United States (30, 117). This bacterium is a part of the natural ﬂora of coastal marine environments worldwide and has been isolated from water, sediments, and a variety of seafood, including shrimp, ﬁsh, oysters, and clams (4, 7, 25, 26, 43, 97, 109, 116, 118, 149, 165). Consumption of seafood (primarily raw oysters) containing V. vulniﬁcus can result in a severe, fulminant systemic infection. Characteristics of this disease include fever, chills, nausea, hypotensive septic shock, and the formation of secondary lesions on the extremities of patients (11, 22, 41, 74, 115, 146). This primary septicemia is the most lethal infection caused by V. vulniﬁcus , with an average mortality rate exceed-ing 50% (30, 41). A review of 459 U.S. cases reported by the FDA between 1992 and 2007 (J. D. Oliver, unpublished) revealed that 51.6% of the patients died. Interestingly, 85.6% of the cases were male; this aspect of the infection is discussed later in this review. Of 180 cases in 2002 to 2007 for which FDA data were available, 92.8% of patients had consumed raw oysters prior to the onset of symptoms and 95.3% had some preexisting disease(s). The latter are clearly associated with V. infection,
The Noninvasive Measurement of Absolute Cerebral Deoxyhemoglobin Concentration and Mean Optical Path Length in the Neonatal Brain by Second Derivative Near Infrared Spectroscopy

COOPER, C. E. ; ELWELL, C. E. ; MEEK, J. H. ; MATCHER, S. J.; WYATT, J. S. ; COPE, M. ; DELPY, D. T. Department of Paediatrics [C.E. C. , J.H. M. , J.S. W. ] and Medical Physics and Bioengineering [C.E. E. , S.J.M. , M.C. , D.T. D], University College London Medical School, London, United Kingdom Received November 10, 1994; accepted July 13, 1995. Correspondence and reprint requests: Dr. Chris Cooper, Department of Biological and Chemical Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK. Supported by the Medical Research Council (UK), the Wellcome Trust, and Hamamatsu Photonics KK.
Generating Simulated Relevance Feedback: A Prognostic Search approach

Implicit relevance feedback has proved to be a important resource in improving search accuracy and personalization. However, researchers who rely on feedback data for testing their algorithms or other personalization related problems are loomed with problems like unavailability of data, staling up of data and so on. Given these problems, we are motivated towards creating a synthetic user relevance feedback data, based on insights from query log analysis. We call this simulated feedback. We believe that simulated feedback can be immensely beneficial to web search engine and personalization research communities by greatly reducing efforts involved in collecting user feedback. The benefits from "Simulated feedback" are - it is easy to obtain and also the process of obtaining the feedback data is repeatable, customizable and does not need the interactions of the user. In this paper, we describe a simple yet effective approach for creating simulated feedback. We have evaluated our system using the clickthrough data of the users and achieved 77% accuracy in generating click-through data.
Spectral Efficiency of Multipair Massive MIMO Two-Way Relaying With Hardware Impairments

We consider a multipair massive multiple-input multiple-output (MIMO) two-way relaying system, where multiple pairs of single-antenna devices exchange data with the help of a relay employing a large number of antennas <inline-formula> <tex-math notation="LaTeX">${N}$ </tex-math></inline-formula>. The relay consists of low-cost components that suffer from hardware impairments. A large-scale approximation of the spectral efficiency with maximum ratio processing is derived in closed form, and the approximation is tight as <inline-formula> <tex-math notation="LaTeX">${N \to \infty }$ </tex-math></inline-formula>. It is revealed that for a fixed hardware quality, the impact of the hardware impairments vanishes asymptotically when <inline-formula> <tex-math notation="LaTeX">${N}$ </tex-math></inline-formula> grows large. Moreover, the impact of the impairments may even vanish when the hardware quality is gradually decreased with <inline-formula> <tex-math notation="LaTeX">${N}$ </tex-math></inline-formula>, if a scaling law is satisfied. Finally, numerical results validate that multipair massive MIMO two-way relaying systems are robust to hardware impairments at the relay.
Shallow-Transfer Based Machine Translation for Spanish and Aragonese Juan Pablo Martı́nez Cortés

s_an. nt.bz2 for Spanish and Aragonese, respectively. Available from https://github.com/jimregan/ es-an-sentences Table 1: Example first sentences from the Wikipedia articles “Mar”. es Un mar es una masa de agua salada de tamaño inferior al océano an A mar u o mar ye una masa d’augua salada de grandaria inferior a l’ocián A sea is a body of salt water smaller than an ocean Table 2: Example extract from the DBpedia abstract dataset. es John Joseph Nicholson es un actor, productor, guionista y director de cine estadounidense doce veces nominado y tres veces ganador del Premio de la Academia. En activo como actor desde 1958. an Jack Nicholson (nombre artistico de John Joseph Nicholson) ye un actor y director cinematografico estatounitense, naixito o 22 d’abril de 1937 en Nueva York. Gloss es John Joseph Nicholson is an actor, producer, screenwriter and director of American cinema twelve times nominated and three times winner of the Academy Award. Active as an actor since 1958. Gloss an Jack Nicholson (artistic name of John Joseph Nicholson) is an American actor and director, born 22 April 1937 in New York. tions, both for normalisation of non-standard forms, and for cognate induction; and to build a set of equivalent suffixes, which, as well as functioning as transformations, also served as a means of filtering words for equivalence, and for assigning categories: for example, -dá, -dat, daz and -datz all refer to the same feminine noun (-dat, -datz in the standard orthography), which typically have cognates with the suffix -dad, -dades in Spanish: for example, (uniformidat, uniformidatz (“uniformity”, “uniformities”) in Aragonese, uniformidad, uniformidades in Spanish. Cognate induction was then performed by filtering words by suffix, applying the extracted transformations, and comTable 3: SPARQL query used to extract abstracts.
Optimized Synthesis of Concurrently Checked Controllers

A method for introducing online test facilities in a controller with a very low overhead is presented. This online test consists of detecting illegal paths in the control flow graph. These illegal paths may be due either to permanent faults or to transient errors. The state code flow is compacted through polynomial division. An implicit justifying signature method is applied at the state code level and ensures identical signatures before each join mode of the control flow graph. The signatures are then independent of the path followed previously in the graph, and the comparison to reference data is greatly facilitated. This property is obtained by a state assignment, nearly without area overhead. The controllers can then be checked by signature analysis, either by a built-in monitor or by an external checker. >
Human papillomavirus molecular biology and disease association

Human papillomaviruses (HPVs) have evolved over millions of years to propagate themselves in a range of different animal species including humans. Viruses that have co‐evolved slowly in this way typically cause chronic inapparent infections, with virion production in the absence of apparent disease. This is the case for many Beta and Gamma HPV types. The Alpha papillomavirus types have however evolved immunoevasion strategies that allow them to cause persistent visible papillomas. These viruses activate the cell cycle as the infected epithelial cell differentiates in order to create a replication competent environment that allows viral genome amplification and packaging into infectious particles. This is mediated by the viral E6, E7, and E5 proteins. High‐risk E6 and E7 proteins differ from their low‐risk counterparts however in being able to drive cell cycle entry in the upper epithelial layers and also to stimulate cell proliferation in the basal and parabasal layers. Deregulated expression of these cell cycle regulators underlies neoplasia and the eventual progression to cancer in individuals who cannot resolve high‐risk HPV infection. Most work to date has focused on the study of high‐risk HPV types such as HPV 16 and 18, which has led to an understanding of the molecular pathways subverted by these viruses. Such approaches will lead to the development of better strategies for disease treatment, including targeted antivirals and immunotherapeutics. Priorities are now focused toward understanding HPV neoplasias at sites other than the cervix (e.g. tonsils, other transformation zones) and toward understanding the mechanisms by which low‐risk HPV types can sometimes give rise to papillomatosis and under certain situations even cancers. Copyright © 2015 John Wiley & Sons, Ltd.
Mediation by 5‐HT3 receptors of an excitatory effect of 5‐HT on dorsal vagal preganglionic neurones in anaesthetized rats: an ionophoretic study

1 . Extracellular recordings were made from 141 vagal preganglionic neurones in the dorsal vagal nucleus (DVN). The effects of ionophoretic administration of 5‐hydroxytryptamine (5‐HT), the 5‐HT3 receptor agonist, phenylbiguanide (PBG) and the antagonists, granisetron and tropisetron (ICS 205–930) on these vagal preganglionic neurones were studied in pentobarbitone sodium anaesthetized rats. 2 . Ionophoretic application of 5‐HT at low currents (< 10 nA) increased the activity in 46 (73%) of 63 neurones tested. Application of granisetron (5–20 nA) or tropisetron (5–20 nA) abolished or attenuated the 5‐HT excitatory responses in 8 out of 11 and 5 out of 5 neurones respectively. At the currents used, neither antagonist had any effect on baseline firing rate. 3 . Ionophoresis of the selective 5‐HT3 receptor agonist, phenylbiguanide (0–40 nA) excited 54 (82%) of the 66 vagal neurones tested, whilst the remaining 12 neurones were unaffected. 4 . Granisetron applied either ionophoretically (8/11) or intravenously (3/3), abolished or attenuated the excitations evoked by PBG. Similarly, tropisetron administered either ionophoretically (2/3) or intravenously (2/2), attenuated the PBG excitation. In contrast, the PBG excitations were unaffected by the 5‐HT2 receptor antagonist, cinanserin (2/2), and the selective 5‐HT1A receptor antagonist, WAY‐100802 (6/6). 5 . In conclusion, excitation of vagal preganglionic neurones evoked by ionophoretic application of 5‐HT is mediated in part by 5‐HT3 receptors and activation of 5‐HT3 receptors on and/or in the vicinity of vagal motoneurones causes excitation of these neurones.