Miracle-dz/UniFAR-FTUs huggingface dataset:
GPMatch: A Bayesian causal inference approach using Gaussian process covariance function as a matching tool

A Gaussian process (GP) covariance function is proposed as a matching tool for causal inference within a full Bayesian framework under relatively weaker causal assumptions. We demonstrate that matching can be accomplished by utilizing GP prior covariance function to define matching distance. The matching properties of GPMatch is presented analytically under the setting of categorical covariates. Under the conditions of either (1) GP mean function is correctly specified; or (2) the GP covariance function is correctly specified, we suggest GPMatch possesses doubly robust properties asymptotically. Simulation studies were carried out without assuming any a priori knowledge of the functional forms of neither the outcome nor the treatment assignment. The results demonstrate that GPMatch enjoys well-calibrated frequentist properties and outperforms many widely used methods including Bayesian Additive Regression Trees. The case study compares the effectiveness of early aggressive use of biological medication in treating children with newly diagnosed Juvenile Idiopathic Arthritis, using data extracted from electronic medical records. Discussions and future directions are presented.
Development of Novel Musical Stimuli to Investigate the Perception of Musical Emotions in Individuals With Hearing Loss

Background Many studies have examined the perception of musical emotion using excerpts from familiar music that includes highly expressed emotions to classify emotional choices. However, using familiar music to study musical emotions in people with acquired hearing loss could produce ambiguous results as to whether the emotional perception is due to previous experiences or listening to the current musical stimuli. To overcome this limitation, we developed new musical stimuli to study emotional perception without the effects of episodic memory. Methods A musician was instructed to compose five melodies with evenly distributed pitches around 1 kHz. The melodies were created to express the emotions of happy, sad, angry, tender, and neutral. To evaluate whether these melodies expressed the intended emotions, two methods were applied. First, we classified the expressed emotions of melodies with selected musical features from 60 features using genetic algorithm-based k-nearest neighbors. Second, forty-four people with normal hearing participated in an online survey regarding the emotional perception of music based on dimensional and discrete approaches to evaluate the musical stimuli set. Results Twenty-four selected musical features produced classification for intended emotions with an accuracy of 76%. The results of the online survey in the normal hearing (NH) group showed that the intended emotions were selected significantly more often than the others. K-means clustering analysis revealed that melodies with arousal and valence ratings corresponded to representative quadrants of interest. Additionally, the applicability of the stimuli was tested in 4 individuals with high-frequency hearing loss. Conclusion By applying the individuals with NH, the musical stimuli were shown to classify emotions with high accuracy, as expressed. These results confirm that the set of musical stimuli can be used to study the perceived emotion in music, demonstrating the validity of the musical stimuli, independent of innate musical bias such as due to episodic memory. Furthermore, musical stimuli could be helpful for further studying perceived musical emotion in people with hearing loss because of the controlled pitch for each emotion.
Quantum sensing and ghost imaging

We show that the strategy of ghost imaging can be successfully adapted to the estimation of parameters of open systems. Two entangled qubits, so that only one of them interacts with a depolarizing sample, may lead to precision in the estimation of the depolarizing parameter better than the one corresponding to sending the pair, entangled or not, through the sample. As opposed to ghost imaging, entanglement plays an essential role in this case, as does the entangling detection procedure, consisting in projecting the final state on a Bell-state basis. For isotropic depolarization, quantum advantage is obtained only when the final state, after interaction with the sample, is not entangled anymore.
Integer PCA and wavelet transforms for multispectral image compression

Remote sensing produces large amounts or digital data which are collected into databases. Since a variety of applications utilize the multispectral data, the data cannot be compressed with lossy methods. In this paper, we propose the combination of two reversible methods for the lossless compression of the multispectral images: first, principal component analysis is applied to the spectra of the image and then, the integer wavelet transform is applied to the residual image to further concentrate the energy and reduce the entropy. The coding quality of the method is measured with the the zero-order entropy, and it is clearly lower with this method than with the methods found from the literature. Depending on the AVIRIS image, the entropies varied from 5.6 to 5.9 bits per pixel. With the same images, the actual compression ratios, calculated from the files sizes, were in the range from 2.8 to 2.9.
Disentangling morphology and genetics in two voles (Microtus pennsylvanicus and M. ochrogaster) in a region of sympatry

Species in recent, rapid radiations can be difficult to distinguish from one another due to incomplete sorting of traits, insufficient time for novel morphologies to evolve, and elevated rates of hybridization and gene flow. The vole genus Microtus (58 spp.) is one such system where all three factors are likely at play. In the central United States, the prairie vole, Microtus ochrogaster, and the eastern meadow vole, M. pennsylvanicus, occur in sympatry and can be distinguished on the basis of molar cusp patterns but are known to be exceptionally difficult to distinguish using external morphological characters. Using a combination of morphometrics, pelage color analyses, and phylogenetics, we explored which traits are most effective for species identification and whether these same traits can be used to identify the subspecies M. o. ohionensis. While we were able to identify six traits that differed significantly between M. ochrogaster and M. pennsylvanicus, we also found substantial measurement overlap which limits the utility of these traits for species identification. The subspecies M. o. ohionensis was particularly difficult to distinguish from M. p. pennsylvanicus, and we did not find any evidence that this subspecies forms a distinct genetic clade. Furthermore, the full species M. ochrogaster and M. pennsylvanicus did not form reciprocal clades in phylogenetic analyses. We discuss several possible reasons for these patterns, including unrecognized variation in molar cusp patterns and/or localized hybridization. Overall, our results provide useful information that will aid in the identification of these species and subspecies in the future, and provides a case study of how genetics, morphometrics, and fur color analyses can be used to disentangle signatures of evolutionary history and hybridization.
Large eddy simulations of the turbulent channel flow over dimpled surfaces

Reducing skin friction has a key role in the efficiency of rail, highway, and airway transport vehicles or naval systems such as ships and underwater vehicles. In recent years, there is a growing interest in investigating turbulent drag-reducing capabilities of dimpled surfaces, which have great potential as a passive solution, while there still exists highly conflicting views and drag reduction rates reported in the literature as well as a lack of information about the drag reduction mechanism. In this study, large-eddy simulations (LES) were performed to investigate the characteristics and physical mechanism of the fluid flow over dimpled surfaces in a fully developed channel flow. The Reynolds number based on the channel height and the mean bulk velocity was nearly 5600 for all cases examined. Within the framework of the study, various dimple depth to diameter ratios as well as different dimple arrangements and geometries were considered. The detailed mean and instantaneous flow fields, turbulent kinetic energy budget and spectral characteristics of the flow are presented. The study revealed the potential of the dimpled surface in reducing skin friction and provided critical information about the flow features affecting the performance of the dimples.
Tumor Suppressor Role of INPP4B in Chemoresistant Retinoblastoma

The chemotherapy of retinoblastoma (RB), a malignant ocular childhood disease, is often limited by the development of resistance against commonly used drugs. We identified inositol polyphosphate 4-phosphatase type II (INPP4B) as a differentially regulated gene in etoposide-resistant RB cell lines, potentially involved in the development of RB resistances. INPP4B is controversially discussed as a tumor suppressor and an oncogenic driver in various cancers, but its role in retinoblastoma in general and chemoresistant RB in particular is yet unknown. In the study presented, we investigated the expression of INPP4B in RB cell lines and patients and analyzed the effect of INPP4B overexpression on etoposide resistant RB cell growth in vitro and in vivo. INPP4B mRNA levels were significantly downregulated in RB cells lines compared to the healthy human retina, with even lower expression levels in etoposide-resistant compared to the sensitive cell lines. Besides, a significant increase in INPP4B expression was observed in chemotherapy-treated RB tumor patient samples compared to untreated tumors. INPP4B overexpression in etoposide-resistant RB cells resulted in a significant reduction in cell viability with reduced growth, proliferation, anchorage-independent growth, and in ovo tumor formation. Caspase-3/7-mediated apoptosis was concomitantly increased, suggesting a tumor suppressive role of INPP4B in chemoresistant RB cells. No changes in AKT signaling were discernible, but p-SGK3 levels increased following INPP4B overexpression, indicating a potential regulation of SGK3 signaling in etoposide-resistant RB cells. RNAseq analysis of INPP4B overexpressing, etoposide-resistant RB cell lines revealed differentially regulated genes involved in cancer progression, mirroring observed in vitro and in vivo effects of INPP4B overexpression and strengthening INPP4B's importance for cell growth control and tumorigenicity.
Fish as bio-indicator tool for assessing estuarine health

Fish Health Index and Index of Biotic Integrity directly indicates environmental health and was used in our monitoring at Coleroon, Vellar and Uppanar, estuaries in the southeast coast of India. The use of cast nets revealed 104 species of fish that belongs to 69 genera, 44 families and 10 orders. Assessment using fish health index at Coleroon, Vellar and Uppanar estuaries produced scores of 4.8692, 8.4981 and 1.4042 which means Vellar has better health than Coleroon and Uppanar. In addition, 12 metrics were used to produce the index of biotic integrity where total scores varied from 18 to 51. With Vellar achieving higher scores than Coleroon and Uppanar estuary, a Two-way ANOVA was employed to validate the data with significant achievement (P<0.005). Therefore, we can safely associate Coleroon, Vellar and Uppanar with ‘Fair’, ‘Good’ and ‘Very poor’ grades. Also, visual depiction of Vellar demarcates it as pristine in comparison to Coleroon and Uppanar that are subject to impairments along with dominance of omnivorous fishes. Knowledge from this study eases monitoring of important estuaries particularly for food security so that management sustains community livelihood.
Condom-Related Stigma Scale among Men Who Have Sex with Men in China: Development and Psychometric Tests

Condom-related stigma is a frequently mentioned barrier to consistent condom use among men who have sex with men (MSM). Based on the concept and operational definition of condom-related stigma recently defined by our team, we developed the 20-item condom-related stigma scale (CRSS) and examined its psychometric properties among 433 MSM in China, following DeVellis’s scale development guidelines. The content validity, convergent validity, empirical validity, factorial validity, scale score reliability, split-half reliability, and test–retest reliability for the CRSS were all assessed. The scale consists of four domains: perceived distrust, perceived potential HIV/STI risk, perceived embarrassment, and perceived violation of the traditional understanding of sexual intercourse. The CRSS has good validity (the scale-level content validity index was 0.99; the empirical validity was greater than 0.70) and high reliability (the Cronbach’s alpha coefficient overall was 0.926; the split-half reliability overall was 0.795; the test–retest reliability overall was 0.950). This scale is recommended for assessing the level of condom-related stigma among Chinese MSM, which can serve as an evaluating indicator for safer-sex interventions to prevent HIV infection among the MSM population in a Chinese cultural context.
Comparing Radiation Dose of Cerebral Angiography Using Conventional and High kV Techniques: A Retrospective Study on Intracranial Aneurysm Patients and a Phantom Study

Evaluation of patient radiation dose after the implementation of a high kV technique during a cerebral angiographic procedure is an important issue. This study aimed to determine and compare the patient radiation dose of intracranial aneurysm patients undergoing cerebral angiography using the conventional and high kV techniques in a retrospective study and a phantom study. A total of 122 cases (61 cases with conventional technique and 61 cases with high kV technique) of intracranial aneurysm patients, who underwent cerebral angiographic procedure and met the inclusion criteria, were recruited. The radiation dose and the angiographic exposure parameters were reviewed retrospectively. The radiation dose in the phantom study was conducted using nanoDotTM optically stimulating luminescence (OSLD), which were placed on the scalp of the head phantom, the back of the neck, and the phantom skin at the position of the eyes. The standard cerebral angiographic procedure using the conventional and high kV techniques was performed following the standard protocol. The results showed that the high kV technique significantly reduced patient radiation dose and phantom skin dose. This study confirms that the implementation of a high kV technique in routine cerebral angiography for aneurysm diagnosis provides an effective reduction in radiation dose. Further investigation of radiation dose in other interventional neuroradiology procedures, particularly embolization procedure, should be performed.
Influence mechanism of adoption willingness of personalized recommendation information on e-commerce platforms based on structural equation modeling

Personalized recommendation information services in e-commerce platforms can help users get the information they need faster. Still, users also worry about the risk of privacy disclosure and illegal use. Users' willingness to adopt personalized recommendation information on e-commerce platforms and its influence mechanism is unclear. This paper explores how users weigh the conflict between convenience and privacy risks brought by personalized recommendation, builds an influencing factors model of the willingness to adopt personalized recommendation information on ecommerce platforms, and uses structural equation modeling (SEM) for analysis and verification. The results show that the perceived privacy risk negatively influences the adoption willingness, but the impact level is lower than expected. The adoption willingness of personalized recommendation information is more influenced by its usefulness.
Tracking auditory mismatch negativity responses during full conscious state and coma

The mismatch negativity (MMN) is considered the electrophysiological change-detection response of the brain, and therefore a valuable clinical tool for monitoring functional changes associated with return to consciousness after severe brain injury. Using an auditory multi-deviant oddball paradigm, we tracked auditory MMN responses in seventeen healthy controls over a 12-h period, and in three comatose patients assessed over 24 h at two time points. We investigated whether the MMN responses show fluctuations in detectability over time in full conscious awareness, or whether such fluctuations are rather a feature of coma. Three methods of analysis were utilized to determine whether the MMN and subsequent event-related potential (ERP) components could be identified: traditional visual analysis, permutation t-test, and Bayesian analysis. The results showed that the MMN responses elicited to the duration deviant-stimuli are elicited and reliably detected over the course of several hours in healthy controls, at both group and single-subject levels. Preliminary findings in three comatose patients provide further evidence that the MMN is often present in coma, varying within a single patient from easily detectable to undetectable at different times. This highlights the fact that regular and repeated assessments are extremely important when using MMN as a neurophysiological predictor of coma emergence.
Helping Girls with Deafness Victims of Sexual Harassment: REBT with Bisindo as a Mental Health Education Service in Schools

This article examines the girls with deafness in schools who experience sexual harassment. The purpose of this study is to find a post-sexual harassment service model that is in accordance with the characteristics of girls with deafness and explain how schools pay attention to well-organized and theoretical programs using a preventive approach to mental health. Participants totaled 166 users consisting of 105 teachers, 38 students, 8 lecturers, 5 members of organizations for the deaf and other professions. The results showed that sexual harassment can occur physically and verbally towards the girls with deafness which can cause trauma. The girls with deafness are more at risk of being sexually abused than boys. They experienced very significant intimidation. The limited communication characteristics of girls with deafness cause trauma of sexual harassment, irrational beliefs that interfere with social functioning in the environment. There is a need for intervention in special mental health service programs such as REBT with Bisindo that are in accordance with the characteristics of students with deafness. The role of the teacher in preparing children to deal with face life in an increasingly complex society.
Initiation of shape instabilities of free boundaries in planar Cauchy–Stefan problems

The linearized shape stability of melting and solidifying fronts with surface tension is discussed in this paper by using asymptotic analysis. We show that the melting problem is always linearly stable regardless of the presence of surface tension, and that the solidification problem is linearly unstable without surface tension, but with surface tension it is linearly stable for those modes whose wave numbers lie outside a certain finite interval determined by the parameters of the problem. We also show that if the perturbed initial data is zero in the vicinity of the front, but otherwise quite general, it does not affect the stability. The present results complement those in Chadam & Ortoleva [4] which are only valid asymptotically for large time or equivalently for slow-moving interfaces. The theoretical results are verified numerically.
Application of artificial intelligence in diagnosis and treatment of colorectal cancer: A novel Prospect

In the past few decades, according to the rapid development of information technology, artificial intelligence (AI) has also made significant progress in the medical field. Colorectal cancer (CRC) is the third most diagnosed cancer worldwide, and its incidence and mortality rates are increasing yearly, especially in developing countries. This article reviews the latest progress in AI in diagnosing and treating CRC based on a systematic collection of previous literature. Most CRCs transform from polyp mutations. The computer-aided detection systems can significantly improve the polyp and adenoma detection rate by early colonoscopy screening, thereby lowering the possibility of mutating into CRC. Machine learning and bioinformatics analysis can help screen and identify more CRC biomarkers to provide the basis for non-invasive screening. The Convolutional neural networks can assist in reading histopathologic tissue images, reducing the experience difference among doctors. Various studies have shown that AI-based high-level auxiliary diagnostic systems can significantly improve the readability of medical images and help clinicians make more accurate diagnostic and therapeutic decisions. Moreover, Robotic surgery systems such as da Vinci have been more and more commonly used to treat CRC patients, according to their precise operating performance. The application of AI in neoadjuvant chemoradiotherapy has further improved the treatment and efficacy evaluation of CRC. In addition, AI represented by deep learning in gene sequencing research offers a new treatment option. All of these things have seen that AI has a promising prospect in the era of precision medicine.
On Integration of Vibration Suppression and Energy Harvesting Through Piezoelectric Shunting With Negative Capacitance

While negative capacitance (NC) element has the potential of increasing the apparent electro-mechanical coupling in various piezoelectric applications, it generally requires a power supply which may negate its benefit. Indeed, there has been no systematic analysis of NC power consumption in piezoelectric circuitry. In this article, we investigate the combinatorial effect of NC circuit on an integrated design of passive vibration suppression and energy harvesting with LC resonant shunt. We first conduct a power consumption analysis of a representative NC circuit and analyze its influence on piezoelectric energy harvesting. We then explore the tradeoff between vibration suppression through LC shunt with NC element and the net power generation of the energy harvester. It is identified that there exists a range of NC values within which the vibration suppression performance is enhanced while the net power generation remains to be positive. This effectively yields a self-sustainable vibration suppression enhancement scheme with an NC element. Correlated numerical and experimental studies confirm this new finding.
Temperature effects in metal-clad semiconductor nanolasers

Abstract As the field of semiconductor nanolasers becomes mature in terms of both the miniaturization to the true sub-wavelength scale, and the realization of room temperature devices, the integrated treatment of multiple design aspects beyond pure electromagnetic consideration becomes necessary to further advance the field. In this review, we focus on one such design aspect: temperature effects in nanolasers. We summarize recent efforts in understanding the interplay of various temperature-dependent parameters, and study their effects on optical mode and emission characteristics. Building on this knowledge, nanolasers with improved thermal performance can be designed, and their performance evaluated. Although this review focuses on metal-clad semiconductor lasers because of their suitability for dense chip-scale integration, these thermal considerations also apply to the broader field of nanolasers.