Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of cavotricuspid isthmus ablation for typical atrial flutter and heart failure in the elderly—results of a retrospective multi-center study

Introduction While in the CASTLE-AF trial, in patients with atrial fibrillation and heart failure with reduced ejection fraction, interventional therapy using pulmonary vein isolation was associated with outcome improvement, data on cavotricuspid isthmus ablation (CTIA) in atrial flutter (AFL) in the elderly is rare. Methods We included 96 patients between 60 and 85 years with typical AFL and heart failure with reduced or mildly reduced ejection fraction (HFrEF/HFmrEF) treated in two medical centers. 48 patients underwent an electrophysiological study with CTIA, whereas 48 patients received rate or rhythm control and guideline-compliant heart failure therapy. Patients were followed up for 2 years, with emphasis on left ventricular ejection fraction (LVEF) over time. Primary endpoints were cardiovascular mortality and hospitalization for cardiac causes. Results Patients with CTIA showed a significant increase in LVEF after 1 (p < 0.001) and 2 years (p < 0.001) in contrast to baseline LVEF. Improvement of LVEF in the CTIA group was associated with significantly lower 2-year mortality (p = 0.003). In the multivariate regression analysis, CTIA remained the relevant factor associated with LVEF improvement (HR: 2.845 CI:95% 1.044–7.755; p = 0.041). Elderly patients (≥ 70 years) further benefited from CTIA, since they showed a significantly reduced rehospitalization (p = 0.042) and mortality rate after 2 years (p = 0.013). Conclusions CTIA in patients with typical AFL and HFrEF/HFmrEF was associated with significant improvement of LVEF and reduced mortality rates after 2 years. Patient age should not be a primary exclusion criterion for CTIA, since patients ≥70 years also seem to benefit from intervention in terms of mortality and hospitalization.
A review on nanoparticles: characteristics, synthesis, applications, and challenges

The significance of nanoparticles (NPs) in technological advancements is due to their adaptable characteristics and enhanced performance over their parent material. They are frequently synthesized by reducing metal ions into uncharged nanoparticles using hazardous reducing agents. However, there have been several initiatives in recent years to create green technology that uses natural resources instead of dangerous chemicals to produce nanoparticles. In green synthesis, biological methods are used for the synthesis of NPs because biological methods are eco-friendly, clean, safe, cost-effective, uncomplicated, and highly productive. Numerous biological organisms, such as bacteria, actinomycetes, fungi, algae, yeast, and plants, are used for the green synthesis of NPs. Additionally, this paper will discuss nanoparticles, including their types, traits, synthesis methods, applications, and prospects.
Air pollution, residents’ concern and commercial health insurance’s sustainable development

As Chinese residents are increasingly concerned about environmental and health issues, the importance of commercial health insurance has come to the fore. Therefore, it is necessary to study the relationship and mechanism between air pollution and commercial health insurance. This paper empirically analyzes the impact and mechanism of air pollution on the sustainable development of Chinese commercial health insurance. The analysis is conducted using the IV-probit and IV-tobit models with thermal inversion as the instrumental variable for air pollution, with Chinese households as the study population and 2018 as the study period. The results show that PM2.5 concentration has a positive and significant effect on both household participation in commercial health insurance and the level of participation, and that residents’ concern is an important channel linking air pollution and commercial health insurance, where pollution reporting plays a negative transmission role, protective behaviors play a positive transmission role, and healthy depreciation plays a positive transmission role. The results of this study contribute to the comprehensive development of China’s social security system and the sustainable development of the commercial health insurance market.
Osteocytes contribute via nuclear receptor PPAR-alpha to maintenance of bone and systemic energy metabolism

Introduction The view that bone and energy metabolism are integrated by common regulatory mechanisms is broadly accepted and supported by multiple strands of evidence. This includes the well-characterized role of the PPARγ nuclear receptor, which is a common denominator in energy metabolism and bone metabolism. Little is known, however, about the role of PPARα nuclear receptor, a major regulator of lipid metabolism in other organs, in bone. Methods A side-by-side comparative study of 5-15 mo old mice with global PPARα deficiency (αKO) and mice with osteocyte-specific PPARα deficiency (αOTKO) in order to parse out the various activities of PPARα in the skeleton that are of local and systemic significance. This study included transcriptome analysis of PPARα-deficient osteocytes, and analyses of bone mass and bone microarchitecture, systemic energy metabolism with indirect calorimetry, and differentiation potential of hematopoietic and mesenchymal bone cell progenitors. These analyses were paired with in vitro studies of either intact or silenced for PPARα MLO-A5 cells to determine PPARα role in osteocyte bioenergetics. Results In osteocytes, PPARα controls large number of transcripts coding for signaling and secreted proteins which may regulate bone microenvironment and peripheral fat metabolism. In addition, PPARα in osteocytes controls their bioenergetics and mitochondrial response to stress, which constitutes up to 40% of total PPARα contribution to the global energy metabolism. Similarly to αKO mice, the metabolic phenotype of αOTKO mice (both males and females) is age-dependent. In younger mice, osteocyte metabolism contributes positively to global energetics, however, with aging the high-energy phenotype reverts to a low-energy phenotype and obesity develops, suggesting a longitudinal negative effect of impaired lipid metabolism and mitochondrial dysfunction in osteocytes deficient in PPARα. However, bone phenotype was not affected in αOTKO mice except in the form of an increased volume of marrow adipose tissue in males. In contrast, global PPARα deficiency in αKO mice led to enlarged bone diameter with a proportional increase in number of trabeculae and enlarged marrow cavities; it also altered differentiation of hematopoietic and mesenchymal marrow cells toward osteoclast, osteoblast and adipocyte lineages, respectively. Discussion PPARα role in bone is multileveled and complex. In osteocytes, PPARα controls the bioenergetics of these cells, which significantly contributes to systemic energy metabolism and their endocrine/paracrine function in controlling marrow adiposity and peripheral fat metabolism.
The Shoot Apical Meristem: A Tree’s Best Bud

Every spring, something seemingly miraculous happens in the woods in certain parts of the world—thousands of leaves burst from buds on bare tree branches, transforming the landscape from the browns and grays of winter to the bright greens of spring and summer. Although this process is most obvious in regions with drastic seasonal changes, seed plants all over the world regularly produce and lose leaves as they grow. How does this happen? Where do these leaves come from? The cells that make up these leaves are produced by a tiny cluster of cells called the shoot apical meristem. The cells in the shoot apical meristem have the potential to develop into various kinds of cells. Through cell division, meristem cells eventually produce all the above-ground parts of a plant, including leaves. In this article, we explain how meristems function and highlight how these tiny clusters of cells impact our day-to-day lives. We will also provide suggestions for observing meristems at work.
Stress in wildlife: comparison of the stress response among domestic, captive, and free-ranging animals

The stress response, which involves joint activity of the nervous and endocrine systems, is one of the basic adaptive mechanisms that ensures the survival of the individual. The activation of the sympathetic nervous system, the sympathetic-adrenal-medullary axis, and the hypothalamic–pituitary–adrenal axis enables organisms to respond to endogenous and exogenous challenges. Repeated short-term stress leads to long-term stress, which disrupts physiological homeostasis. Unlike domestic animals, wild animals are not protected from environmental and weather influences or treated for diseases. In addition, climate change, habitat fragmentation and loss, and urban stressors (such as light, noise and chemical pollution; xenobiotics; traffic; and buildings) affect individual wildlife and populations. In this review, we have attempted to depict the magnitude of the stress response in wildlife and related domestic animals as well as in captive and free-ranging animals. The intensity of the stress response can be estimated by determining the concentration of glucocorticoids in body fluids, tissues, and excreta. A comparison of results from different studies suggests that domestic animals have lower fecal and hair glucocorticoid concentrations than related wild animals. Additionally, fecal and hair glucocorticoid concentrations in captive animals are higher than in free-ranging animals of the same species. As there are limited data on this topic, we cannot draw definitive conclusions about glucocorticoid concentration and stress response. Further studies are needed to clarify these issues.
Evaluating the potential impact of selection for the A2 milk allele on inbreeding and performance in Australian Holstein cattle

Selection decisions are generally based on estimated breeding values (EBV) for a combination of traits that are polygenic (e.g. milk production). However, in some cases, there is additional intense selection for a single allele, or SNP, for a perceived benefit, such as selection for polled or A2 milk. Using a dataset where the A2 mutation was imputed using a reference population with whole genome sequence, we tested the hypothesis that intense selection in Australian Holstein cattle for the A2 allele in the β-casein gene may have resulted in increased inbreeding. We also estimated the average difference in performance between animals homozygous for the A1 or A2 allele for a range of traits. Using high-density genotypes we compared differences in genome-wide and regional inbreeding between Holstein cows homozygous for either the A1 or A2 β-casein alleles i.e. A1/A1 or A2/A2. This study shows that between the years 2000 to 2017, the frequency of the A2/A2 genotype increased by 20% in Holstein cows (from 32% to 52%). Our results suggest that selection for homozygosity at the β-casein A2 allele has increased inbreeding both across the genome and on chromosome 6 in A2/A2 Holstein cows. Animals that were A2/A2 were twice as likely to have a run of homozygosity of at least 1Mb long across the β-casein locus compared to animals that were A1/A1. Cows that are homozygous for the A2 allele had an average protein yield EBV advantage of 0.24 genetic standard deviations (SD) compared to A1/A1 homozygous cows. In contrast, A2/A2 homozygous animals were on average 0.2 genetic SD inferior on fertility EBV. As a result, the difference in the overall economic index (that includes traits contributing to profitability) there was only a small advantage of 0.05 SD for A2/A2 cows compared to A1/A1 cows. However, strong selection for the A2 allele has likely led to a higher level of regional and overall inbreeding which in the long term could harm genetic progress for some or all economic traits. Therefore, applying approaches that mitigate rapid inbreeding while selecting for preferred alleles and quantitative traits may be desirable.
The Art of Signaling: Fifty Years of Coding Theory

In 1948 Shannon developed fundamental limits on the efficiency of communication over noisy channels. The coding theorem asserts that there are block codes with code rates arbitrarily close to channel capacity and probabilities of error arbitrarily close to zero. Fifty years later, codes for the Gaussian channel have been discovered that come close to these fundamental limits. There is now a substantial algebraic theory of error-correcting codes with as many connections to mathematics as to engineering practice, and the last 20 years have seen the construction of algebraic-geometry codes that can be encoded and decoded in polynomial time, and that beat the Gilbert-Varshamov bound. Given the size of coding theory as a subject, this review is of necessity a personal perspective, and the focus is reliable communication, and not source coding or cryptography. The emphasis is on connecting coding theories for Hamming and Euclidean space and on future challenges, specifically in data networking, wireless communication, and quantum information theory.
Phenobarbital-Based Protocol for Alcohol Withdrawal Syndrome in a Medical ICU: Pre-Post Implementation Study

OBJECTIVES: We assessed the efficacy and safety of PB compared with benzodiazepine (BZD)-based protocols in treating AWS in MICU. DESIGN: Single-center, pre-post protocol implementation study. SETTING: The setting is a forty-bed MICU in a tertiary-level academic medical center. PATIENTS: We included all patients admitted to the MICU with a primary diagnosis of AWS. INTERVENTIONS: Intravenous PB 260 mg followed by 130-mg doses every 15–30 minutes as needed up to 15 mg/kg of ideal body weight versus escalating doses of BZD, to achieve a Clinical Institute Withdrawal Assessment Alcohol Scale-Revised score less than 10. MEASUREMENTS AND MAIN RESULTS: ICU and hospital length of stay (LOS), in addition to safety measures were the main outcomes of the study. A total of 102 patients were included, 51 in the PB arm and 51 in the BZD arm. There were no differences in baseline clinical characteristics. Half the patients in each group were admitted with delirium tremens. The use of PB-based protocol was associated with 35% reduction in median ICU LOS (1.5 d [interquartile range, 1.2–2.4 d] vs 2.3 d [1.4–4.8 d]; p = 0.009) and 50% reduction in hospital LOS (3 d [2.7–4 d] vs 6 d [4–10 d]; p < 0.001). After adjustment for comorbidities and clinical factors, PB protocol decreased ICU LOS days by 40% (95% CI; 25.8–53.5%). PB group required fewer adjunctive medications to control symptoms (0.7 [0.5–1] vs 2.5 [2–3]; p < 0.001), less need for intubation (1/51 [2%] vs 10/10 [19.6%]; p = 0.023) and less need for physical restraint (19/51 [37.3%] vs 29/51 [56.9%]; p = 0.047), compared with the BZD group. CONCLUSIONS: A protocol utilizing rapidly escalating doses of PB over a short period is an effective and safe alternative to BZD in treating AWS in MICU.
High-Voltage Gain Ripple-Free Resonant DC–DC Converter Using Active Voltage-Quadrupler

This article presents a high-voltage gain ripple-free resonant dc–dc converter using an active voltage-quadrupler. By incorporating an active voltage-quadrupler at the secondary side of the transformer, the circuit achieved a very high-voltage gain. Without using extra input inductors, the inherent dual transformer plus interleaved active-clamped circuit operating with a fixed duty-ratio of 0.5 generate a ripple-free input current, which extends the lifetime of the fuel cell and shrinks the size of the input capacitive filter. This asymmetric structure of the active-clamp circuit requires an extra dead time for one of the secondary-side switches to achieve zero-voltage switching turn-on. After the extra dead time for one of the secondary-side switches is applied, all power components of the active voltage quadrupler cell are turned on and off with soft switching. The resonant capacitor voltages are unbalanced due to the extra dead time, but they are compensated by applying different secondary-side duty ratios. The operating principle and steady-state characteristics of the proposed converter were analyzed in detail. We built a 1-kW/700-V prototype that copes with 48–72 V inputs, and tested to verify the theoretical analysis.
Xanthine Dehydrogenase Is a Modulator of Dopaminergic Neurodegeneration in Response to Bacterial Metabolite Exposure in C. elegans

Oxidative stress is a contributing factor to Parkinson’s disease (PD). Considering the prevalence of sporadic PD, environmental exposures are postulated to increase reactive oxygen species and either incite or exacerbate neurodegeneration. We previously determined that exposure to the common soil bacterium, Streptomyces venezuelae (S. ven), enhanced oxidative stress and mitochondrial dysfunction in Caenorhabditis elegans, leading to dopaminergic (DA) neurodegeneration. Here, S. ven metabolite exposure in C. elegans was followed by RNA-Seq analysis. Half of the differentially identified genes (DEGs) were associated with the transcription factor DAF-16 (FOXO), which is a key node in regulating stress response. Our DEGs were enriched for Phase I (CYP) and Phase II (UGT) detoxification genes and non-CYP Phase I enzymes associated with oxidative metabolism, including the downregulated xanthine dehydrogenase gene, xdh-1. The XDH-1 enzyme exhibits reversible interconversion to xanthine oxidase (XO) in response to calcium. S. ven metabolite exposure enhanced XO activity in C. elegans. The chelation of calcium diminishes the conversion of XDH-1 to XO and results in neuroprotection from S. ven exposure, whereas CaCl2 supplementation enhanced neurodegeneration. These results suggest a defense mechanism that delimits the pool of XDH-1 available for interconversion to XO, and associated ROS production, in response to metabolite exposure.
A Multi-Scale Spatial Difference Approach to Estimating Topography Correlated Atmospheric Delay in Radar Interferograms

The Interferometric Synthetic Aperture Radar (InSAR) has been widely used as a powerful technique for monitoring land surface deformations over the last three decades. InSAR observations can be plagued by atmospheric phase delays; some have a roughly linear relationship with the ground elevation, which can be approximated using a linear model. However, the estimation results of this linear relationship are sometimes affected by phase ramps such as orbital errors, tidal loading, etc. In this study, we present a new approach to estimate the transfer function of vertical stratification phase delays and the transfer function of phase ramps. Our method uses the idea of multi-scale spatial differences to decompose the atmospheric phase delay into the vertical stratification component, phase ramp component, and other features. This decomposition makes the correlation between the vertical stratification phase delays and topography more significant and stable. This can establish the correlation between the different scales and phase ramps. We demonstrate our approach using a synthetic test and two real interferograms. In the synthetic test, the transfer functions estimated by our method were closer to the design values than those estimated by the full interferogram–topography correlation approach and the band-pass filtering approach. In the first real interferogram, out of the 9 sub-regions corrected by the proposed method, 7 sub-regions were outperformed the full interferogram–topography correlation approach, and 8 sub-regions were superior to the band-pass filtering method. Our technique offers a greater correction effect and robustness for coseismic deformation signals in the second real interferogram.
Parapharyngeal Metastasis of Papillary Carcinoma of Thyroid Gland: A Case Report and a Review of the Literature

Papillary carcinoma is the most frequently encountered differentiated thyroid carcinoma. Usually, metastasis occurs along lymphatic pathways in the central compartment and along the jugular chain. Nevertheless, lymph node metastasis in the parapharyngeal space (PS) is a rare but possible event. In fact, a lymphatic pathway has been identified that connects the upper pole of the thyroid and the PS. We describe the case of a 45-year-old man with a two-month history of a right neck mass. He underwent a complete diagnostic path that highlighted the presence of a parapharyngeal mass associated with the presence of a thyroid nodule suspected to be malignant. The patient underwent surgery (thyroidectomy and removal of the PS mass that was found to be a metastatic node of papillary thyroid carcinoma). The aim of this case is to underline the importance of detecting these kinds of lesions. Nodal metastasis in PS from thyroid cancer is a rare occurrence that is not easily detectable by a clinical examination until the metastasis reaches a considerable dimension. Computed tomography (CT) and magnetic resonance imaging (MRI) permit early identification, but unfortunately, these are not usually employed as a first-level imaging technique in patients with thyroid cancer. The treatment of choice is surgery with a transcervical approach that allows for better control of the disease and of the anatomical structures. Non-surgical treatments are usually reserved for patients with advanced disease, with satisfactory results.
Classical and quantum dynamics of driven elliptical billiards

Subject of this thesis is the investigation of the classical dynamics of the driven elliptical billiard and the development of a numerical method allowing the propagation of arbitrary initial states in the quantum version of the system. In the classical case, we demonstrate that there is Fermi acceleration in the driven billiard. The corresponding transport process in momentum space shows a surprising crossover from sub- to normal diffusion. This crossover is not parameter induced, but rather occurs dynamically in the evolution of the ensemble. The four-dimensional phase space is analyzed in depth, especially how its composition changes in different velocity regimes. We will show that the stickiness properties, which eventually determine the diffusion, are intimately connected with this change of the composition of the phase space with respect to velocity. In the course of the evolution, the accelerating ensemble thus explores regions of varying stickiness, leading to the mentioned crossover in the diffusion. In the quantum case, a series of transformations tailored to the elliptical billiard is applied to circumvent the time-dependent Dirichlet boundary conditions. By means of an expansion ansatz, this eventually yields a large system of coupled ordinary differential equations, which can be solved by standard techniques.
Mathematical formalism for agent-based model of proteins interaction inside cancer cell

Agent-based models can be used to describe a wide range of complex systems, in which the constituent elements (agents) communicate with one another and the system’s global dynamics are governed by the local interactions among the agents. Because formal analysis of complex multi-agent systems is challenging, computer simulations are frequently used to investigate them. While computer simulations are extremely valuable, their results are not formally validated by the observed behavior. As a result, a mathematical framework for representing multi-agent systems and formally establishing their properties is required. One such framework is that which translate the Agent based model to polynomial dynamical system. The aim of this work is to represent our existing Agent based model for the interaction of proteins within cancer cell using mathematical formulation and to analyze its dynamic.