Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy of insulin dosing algorithms for high‐fat high‐protein mixed meals to control postprandial glycemic excursions in people living with type 1 diabetes: A systematic review and meta‐analysis

Optimizing postprandial blood glucose (PPG) levels after mixed meals that contain high fat and protein remains a challenge in the treatment of type 1 diabetes. This study evaluated the efficacy of different algorithms used for dosing insulin based on counting units of high fat and high protein (HFHP) meals with the current conventional method of counting carbohydrates alone to control PPG excursions. The MEDLINE, EMBASE, and Cochrane electronic databases were searched, with the analysis restricted to randomized control trials (RCTs). The primary outcome was the PPG (mean and standard deviation) at 240 min. The pooled final estimate was the mean difference (MD) of the PPGs at 240 min using random effect models to account for heterogeneity. In total, 15 studies were identified and included in the systemic review, of which 12 were RCTs, and three studies were non‐randomized trials. The pooled MD of the PPG at 240 min was in favor of additional insulin doses in HFHP meals compared to the carbohydrate counting alone. The statistically significant results favored the combined bolus (30:70) that split over 2 h in insulin pump therapy with pooled MD of the PPG, 240 min of −24.65; 95% CI: −36.59, −8.41; and heterogeneity, 0%. Other statistically significant results favored the additional insulin added to insulin to carb ratio (ICR) of meal bolus (25–60% ICR) in multiple daily injections therapy with the pooled MD of PPG at 240 min, −21.71; 95% CI: −38.45, −4.73; and heterogeneity, 18%. Insulin treatment based on fat and protein content, in addition to carbohydrate counting, is more effective than the carbohydrate counting method alone; however, further research is warranted to determine the best equation for fat and protein counting, particularly in people with multiple daily injections.
The leading-edge vortex over a swift-like high-aspect-ratio wing with nonlinear swept-back geometry

The leading-edge vortex (LEV) is a common flow structure that forms over wings at high angles of attack. Over the years, LEVs were exploited for augmenting the lift of man-made slender delta wings aircraft. However, recent observations suggested that natural flyers with high-aspect-ratio (high-AR) wings, such as the common swift (Apus apus), can also generate LEVs while gliding. We hypothesize that the planform shape and nonlinear sweep (increasing towards the wingtip) enable the formation and control of such LEVs. In this paper, we investigate whether a stationary LEV can form over a nonlinear swept-back high-AR wing inspired by the swift’s wing shape and evaluate its characteristics and potential aerodynamic benefit. Particle image velocimetry (PIV) measurements were performed in a water flume on a high-AR swept-back wing inspired by the swift wing. Experiments were performed at four spanwise sections and a range of angles of attack for a chord-based Reynolds number of 20000 . Stationary LEV structures were identified across the wingspan by utilizing the proper orthogonal decomposition (POD) method for angles of attack of 5∘–15∘. The size and circulation of the stationary LEV were found to grow towards the wingtip in a nonlinear manner due to shear layer feeding and spanwise transport of mass and vorticity within the LEV, thus confirming that nonlinear high-AR swept-back wings can generate stationary LEVs. Our results suggest that the common swift can generate stationary LEVs over its swept-back wings to glide slower and at a higher rate of descent, with the LEVs potentially supporting up to 60% of its weight.
Botulinum Toxin in Facial Aesthetics Affects the Emotion Process: A Meta-analysis of Randomized Controlled Trials

This study aimed to conduct a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of the btulinum toxin-A (BT-A) in patiets with mood disorders. PubMed, Scopus, Web of Science, Cochrane Library and LILACS were searched without restrictions up to July 2022. The PICOS strategy was used for the selection of studies and risk-of-bias assessment was performed using Cochrane’s tool for RCTs. RCTs were included if they compared BT-A treatment on facial muscles in patients with mood disorders to placebo. After assessment of the full texts, seven studies were selected. Five studies had low risk of bias for the generation of random sequence and blinding of participants and professional domains. A total of four studies showed a low risk of bias for the allocation concealment and blinding of the evaluation of the domain results. The domain of selective reports showed a low risk of bias in all included studies. However, four studies presented a high risk of bias for the domain of other biases. The meta-analysis was based on the mean difference or standardized mean difference between the BT-A and placebo groups for each selected trial and revealed that the BT-A group showed a significant improvement in the symptoms of depression when compared to placebo. This study revealed that the BT-A application into mimic muscles of the upper third of the face improves the mood disorders, but it was not possible to guarantee whether the aesthetic benefits can contribute to reducing the severity of the depressive state.
Ultrafast time-resolved spectroscopic imaging using femtosecond amplifying optical Kerr gate

Ultrafast time-gated imaging has gained wide interests due to potential applications such as visualization of ultrafast phenomena or objects in scattering media. The optical Kerr gate (OKG) has been providing useful tools for such applications in the picosecond region: (1) high sensitivity, (2) real time 2D imaging and (3) wide spectral bandwidth. To meet recent demand to realize higher spatial and temporal resolution, shortening of the opening time is necessary. However, there is an inherent trade-off between high sensitivity and fast response in conventional OKG, which limits its performance for time-resolved imaging. Jonusauskas et al. (1997) have developed a new setup (fast setup) to overcome this problem, which uses the optical Kerr effect in gain medium and two perpendicularly polarized pump pulses. They realized an amplifying OKG in the picosecond region using a dye solution. Minoshima et al. (1997) have applied femtosecond pulses to a fast setup to make possible a femtosecond amplifying OKG (fast OKG). In the paper, we demonstrate ultrafast time-resolved spectroscopic imaging using modification of the fast OKG setup and evaluation of its imaging performances.
An overview of mineralocorticoid receptor antagonists as a treatment option for patients with heart failure: the current state-of-the-art and future outlook

ABSTRACT Introduction Mineralocorticoid receptor antagonists (MRAs) improve cardiovascular outcomes in patients with heart failure. These benefits of MRAs vary in different heart failure populations based on left ventricular ejection fraction and associated comorbidities. Areas covered We define the pharmacologic properties of MRAs and the pathophysiological rationale for their utility in heart failure. We outline the current literature on the use of MRAs in different heart failure populations, including reduced and preserved ejection fraction (HFrEF/HFpEF) and acute heart failure decompensation. Finally, we describe the limitations of currently available data and propose future directions of study. Expert opinion While there is strong evidence supporting the use of MRAs in HFrEF, evidence in patients with HFpEF or acute heart failure is less definitive. Comorbidities such as obesity or atrial fibrillation could be clinical modifiers of the response to MRAs and potentially alter the risk/benefit ratio in these subpopulations. Emerging evidence for new non-steroidal MRAs reveal promising preliminary results that, if confirmed in large randomized clinical trials, could favor a change in clinical practice.
Targeting Three Brain Regions (Bilateral SMA, Left and Right DLPFC) Sequentially in One Session Using Combined Repetitive Transcranial Magnetic Stimulation and Intermittent Theta-burst Stimulation in Treatment-refractory Obsessive-compulsive Disorder: A Case Report

Repetitive transcranial magnetic stimulation (rTMS) has been widely used as a therapy for refractory obsessive-compulsive disorder (OCD). However, it remains unclear which exact target and stimulation sequence of rTMS is most effective for OCD. Here, we report the case of an 18-year-old female with treatment-refractory OCD whose symptoms markedly improved after combined rTMS and intermittent theta-burst stimulation over the bilateral dorsolateral prefrontal cortex and supplementary motor area. Our report indicates that combining treatment sequences that stimulate different brain regions sequentially is feasible and may clinically benefit patients suffering from OCD.
Research on Assistant Diagnosis of Fundus Optic Neuropathy Based on Deep Learning

Abstract Purpose The purpose of this study was to use the neural network to distinguish optic edema (ODE), and optic atrophy from normal fundus images and try to use visualization to explain the artificial intelligence methods. Methods Three hundred and sixty-seven images of ODE, 206 images of optic atrophy, and 231 images of normal fundus were used, which were provided by two hospitals. A set of image preprocessing and data enhancement methods were created and a variety of different neural network models, such as VGG16, VGG19, Inception V3, and 50-layer Deep Residual Learning (ResNet50) were used. The accuracy, recall, F1-score, and ROC curve under different networks were analyzed to evaluate the performance of models. Besides, CAM (class activation mapping) was utilized to find the focus of neural network and visualization of neural network with feature fusion. Results Our image preprocessing and data enhancement method significantly improved the accuracy of model performance by about 10%. Among the networks, VGG16 had the best effect, as the accuracy of ODE, optic atrophy and normal fundus were 98, 90, and 95%, respectively. The macro-average and micro-average of VGG16 both reached 0.98. From CAM we can clearly find out that the focus area of the network is near the optic cup. From feature fusion images, we can find out the difference between the three types fundus images. Conclusion Through image preprocessing, data enhancement, and neural network training, we applied artificial intelligence to identify ophthalmic diseases, acquired the focus area through CAM, and identified the difference between the three ophthalmic diseases through neural network middle layers visualization. With the help of assistant diagnosis, ophthalmologists can evaluate cases more precisely and more clearly.
Adaptation of cardiomyogenesis to the generation and maturation of cardiomyocytes from human pluripotent stem cells

The advent of methods for efficient generation and cardiac differentiation of pluripotent stem cells opened new avenues for disease modelling, drug testing, and cell therapies of the heart. However, cardiomyocytes (CM) obtained from such cells demonstrate an immature, foetal‐like phenotype that involves spontaneous contractions, irregular morphology, expression of embryonic isoforms of sarcomere components, and low level of ion channels. These and other features may affect cellular response to putative therapeutic compounds and the efficient integration into the host myocardium after in vivo delivery. Therefore, novel strategies to increase the maturity of pluripotent stem cell‐derived CM are of utmost importance. Several approaches have already been developed relying on molecular changes that occur during foetal and postnatal maturation of the heart, its electromechanical activity, and the cellular composition. As a better understanding of these determinants may facilitate the generation of efficient protocols for in vitro acquisition of an adult‐like phenotype by immature CM, this review summarizes the most important molecular factors that govern CM during embryonic development, postnatal changes that trigger heart maturation, as well as protocols that are currently used to generate mature pluripotent stem cell‐derived cardiomyocytes.
Chemical proteomics reveals interactors of the alarmone diadenosine triphosphate in the cancer cell line H1299 †

Intracellular dinucleoside polyphosphates (NpnNs) have been known for decades but the functional role remains enigmatic. Diadenosine triphosphate (Ap3A) is one of the most prominent examples, and its intercellular concentration was shown to increase upon cellular stress. By employment of previously reported Ap3A‐based photoaffinity‐labeling probes (PALPs) in chemical proteomics, we investigated the Ap3A interactome in the human lung carcinoma cell line H1299. The cell line is deficient of the fragile histidine triade (Fhit) protein, a hydrolase of Ap3A and tumor suppressor. Overall, the number of identified potential interaction partners was significantly lower than in the previously investigated HEK293T cell line. Gene ontology term analysis revealed that the identified proteins participate in similar pathways as for HEK293T, but the percentage of proteins involved in RNA‐related processes is higher for H1299. The obtained results highlight similarities and differences of the Ap3A interaction network in different cell lines and give further indications regarding the importance of the presence of Fhit.
The role of the disc magnetization on the hysteresis behaviour of X-ray binaries

We present a framework for understanding the dynamical and spectral properties of X-ray Binaries, where the presence of an organized large scale magnetic field plays a major role. Such a field is threading the whole accretion disk with an amplitude measured by the disk magnetization � (r, t) = B 2 z /(� oPtot), where Ptot is the total, gas and radiation, pressure. Below a transition radius rJ, a jet emitting disk (the JED) is settled and drives self-collimated non relativistic jets. Beyond rJ, no jet is produced despite the presence of the magnetic field and a standard accretion disc (the SAD) is
The Validity of Health-Related Quality of Life Instruments in Patients With Late-Stage Parkinson’s Disease

Objective To examine the validity of health-related quality of life (Hr-QoL) measures in patients with late-stage Parkinson’s disease (PD). Methods We analysed data from patients with late-stage PD and their carers who were assessed with a range of clinical measures and the EQ-5D-3 L. The DEMQOL-Proxy was completed for 157 patients with a diagnosis of dementia and the PDQ-8 by 401 patients without dementia. Convergent validity was assessed using correlations with measures of Parkinson’s severity, independence and cognitive function, and construct validity using correlations with patients’ own EQ-5D-3 L scores. In addition, we assessed divergent validity using correlations with carers’ own EQ-5D index, EQ-VAS and Zarit caregiver burden scores. Results In patients without dementia, both the PDQ-8 and EQ-5D-3 L correlated with measures of disease severity, dependence and carer burden scores, and PDQ-8 scores moderately with EQ-5D-3 L and EQ-5D-3 L VAS scores. In patients with dementia, EQ-5D-3 L scores correlated with disease severity, cognition and dependence scores, but DEMQOL-Proxy scores were moderately associated only with patients’ dependence and carers’ own EQ-5D-3 L scores but not patients’ disease severity, EQ-5D-3 L or cognitive scores. Conclusions The PDQ-8 and EQ-5D-3 L have adequate validity in late stage PD without dementia, but in those with PD and dementia the EQ-5D-3 L may be preferable to the DEMQOL-Proxy.
Taking the plunge: When is best for hot water immersion to complement exercise in heat and hypoxia

ABSTRACT This investigation assessed the psycho-physiological and performance effects of hot water immersion (HWI) implemented either before or after a repeated-sprint training in hypoxia (RSH) session conducted in the heat. Ten participants completed three RSH trials (3 × 10 × 5-s sprints), conducted at 40°C and simulated altitude of 3000 m. A 30-min monitoring period preceded and followed all exercise sessions. In PRE, the pre-exercise period was HWI, and the post-exercise period was seated rest in temperate conditions. This combination was reversed in POST. In CON, participants were seated in temperate conditions for both periods. Compared to CON, PRE elicited a reduction in power output during each repeated-sprint set (14.8–16.2%, all p < 0.001), and a significantly higher core temperature (Tc) during the pre-exercise period and throughout the exercise session (p < 0.001 and p = 0.025, respectively). In POST, power output and Tc until the end of exercise were similar to CON, with Tc higher at the conclusion of the post-exercise period (p < 0.001). Time across the entire protocol spent ≥38.5°C Tc was significantly longer in PRE (48.1 ± 22.5 min) than POST (31.0 ± 11.3 min, p = 0.05) and CON (15.8 ± 16.3 min, p < 0.001). Employing HWI following RSH conducted in the heat provides effective outcomes regarding physiological strain and cycling performance when compared to pre-exercise or no HWI.
Rescue intracranial stenting in acute ischemic stroke: a preliminary Vietnamese study.

OBJECTIVE In cases of acute ischemic stroke (AIS) caused by intracranial large vessel occlusion, rescue intracranial stenting (RIS) has recently emerged as a treatment option for achieving recanalization when mechanical thrombectomy (MT) fails. However, few studies to date have reported on the beneficial outcomes of RIS. Our goal was to analyze whether RIS use can improve prognosis in patients 3 months post-treatment. PATIENTS AND METHODS A retrospective analysis was performed on a prospective cohort of patients with AIS treated with RIS at Can Tho S.I. S General Hospital. The study inclusion criteria were evidence of intracranial large vessel occlusion, absence of intracranial hemorrhage (ICH), and severe stenosis or reocclusion after MT. Patients with tandem occlusions, failure to follow up after discharge, or severe or fatal illness concomitant with AIS were excluded from the study. The primary outcome was the "non-poor" prognosis status rate at 3 months after RIS and post-procedural symptomatic ICH (sICH). RESULTS The post-treatment outcomes of 85 eligible patients who received RIS between August 2019 and May 2021 were assessed. Of the 85 included patients, 82 (96.5%) achieved successful recanalization, and 4 (4.7%) experienced sICH. At 3-months post-treatment, 47 (55.3%) patients had "non-poor" outcomes, whereas 35 (41.2%) had good outcomes. The use of dual antiplatelet therapy was associated with new infarcts (relative risk [RR]: 0.1; 95% confidence interval [CI]: 0.01-0.7) and sICH occurrence (RR: 0.1; 95% CI: 0.01-0.9). CONCLUSIONS Our study suggests that despite the occurrence of post-procedural sICH in a small proportion of cases, RIS could serve as a useful alternative or additional treatment in the event of MT failure.
Phase transitions in (CH3NH3)3Bi2I9 (MAIB)

Abstract Crystals of tris (methylammonium) nonaiododibismuthate were grown which turned out to be isomorphous with Cs3Bi2I9 and (CH3NH3)3Sb2I9. Two phase transitions, at 223 (second order) and 142 K (first order), were revealed. The low temperature phase transition is characterized by a strong dielectric anomaly. The pyroelectric behaviour could indicate a ferrielectric ordering below 142 K.
Impaired Cognitive Function in Patients with Autonomous Cortisol Secretion in Adrenal Incidentalomas.

CONTEXT Glucocorticoids have potent effects on the central nervous system. However, while patients with Cushing's syndrome frequently report impairments in cognitive function, studies investigating cognitive function in patients with autonomous cortisol secretion (ACS) in adrenal incidentalomas (AIs) are scarce. OBJECTIVE The aim of the present study was to evaluate neurocognitive function in patients with ACS. METHODS AND PATIENTS We prospectively recruited 63 patients with AI, 36 patients with nonfunctional adrenal adenoma (NFA) (46.5 ± 10.5 years) and 27 patients with ACS (48.6 ± 9.1 years); these patients underwent a battery of validated neuropsychological tests. ACS was diagnosed when serum cortisol levels after a 1 mg dexamethasone suppression test (cortisol1 mg DST) ≥ 50 nmol/L. RESULTS Patients with ACS had a higher frequency of subjective memory complaints (40.7% vs. 13.9%, P < 0.05) and a higher proportion of mild cognitive impairment (22.2% vs. 2.8%, P < 0.05) than patients with NFA. Furthermore, patients with ACS had worse performance on working memory and the visuospatial/constructional domain than patients with NFA (all P < 0.05). Serum cortisol1 mg DST was negatively correlated with working memory and visuospatial/constructional domains (r = -0.307 and -0.306, respectively, all P < 0.05). Performance on working memory and visuospatial/constructional domains gradually deteriorated with increases in serum cortisol1 mg DST (all P values for trend < 0.05). Multivariate linear regression analysis showed that serum cortisol1 mg DST was a significant risk factor for impairment of working memory and visuospatial/constructional domains (B = -0.006 and -0.043, respectively, all P < 0.05). CONCLUSIONS The present study was the first to report that ACS is accompanied by impaired cognitive function. Consequently, cognitive function assessment should be incorporated into the clinical evaluation of patients with ACS.
Metric based up-scaling

We consider divergence form elliptic operators in dimension n ≥ 2 with L∞ coefficients. Although solutions of these operators are only Holder continuous, we show that they are differentiable (C1,α) with respect to harmonic coordinates. It follows that numerical homogenization can be extended to situations where the medium has no ergodicity at small scales and is characterized by a continuum of scales by transferring a new metric in addition to traditional averaged (homogenized) quantities from subgrid scales into computational scales and error bounds can be given. This numerical homogenization method can also be used as a compression tool for differential operators.