Miracle-dz/UniFAR-FTUs huggingface dataset:
Cytokine profile and nitric oxide levels in peritoneal macrophages of BALB/c mice exposed to Fucose-Mannose Ligand of Leishmania infantum combined with Glycyrrhizin CURRENT REVIEW

Background The Fucose-Mannose Ligand (FML) of Leishmania infantum is a complex glycoprotein which does not elicit adequate immunogenicity in human. In recent years, adjuvant compounds derived from plants have been used for improving the immunogenicity of the vaccines. Glycyrrhizin (GL) is a natural triterpenoid saponin that has known immunomodulatory activities. In the present study, we investigated the effects of a co-treatment with FML and GL on the production of cytokines and nitric oxide ( NO) by macrophages, in vitro . Methods Lipopolysaccharide (LPS) stimulated murine peritoneal macrophages were treated with FML (5 μg/ml) of Leishmania infantum and various concentrations of GL (1 μg/ml, or 10 μg/ml or 20 μg/ml). After 48h of treatment, cell culture supernatants were recovered and the levels of TNF-α, IL-10, IL-12p70, and IP-10 were measured by sandwich ELISA and NO concentration by Griess reaction. Our results indicated that the treatment of activated with FML plus GL leads to enhanced production of NO, TNF-α, IL-12p70, and reduction of IL-10 levels in comparison with FML treatment alone. therefore,
Delayed Clearance of Ehrlichia chaffeensis Infection in CD4 (cid:1) T-Cell Knockout Mice†

Human monocytic ehrlichiosis is an emerging tick-borne disease caused by the rickettsia Ehrlichia chaffeen- sis . To examine the role of helper T cells in host resistance to this macrophage-tropic bacterium, we assessed E . chaffeensis infections in three mouse strains with differing functional levels of helper T cells. Wild-type, C57BL/6J mice resolved infections in approximately 2 weeks. Major histocompatibility complex class II (MHCII) knockout, B6.129- Abb tm1 mice lacking helper T cells developed persistent infections that were not resolved even after several months. CD4 (cid:1) T-cell-deﬁcient, B6.129S6- Cd4 tm1Knw mice cleared the infection, but the clearance took 2 weeks longer than it did for wild-type mice. C57BL/6J mice resolved infection more rapidly following a second experimental challenge, but B6.129S6- Cd4 tm1Knw mice did not. The B6.129S6- Cd4 tm1Knw mice also developed active E . chaffeensis -speciﬁc immunoglobulin G responses that were slightly lower in concentration and slower to develop than that observed in C57BL/6J mice. E . chaffeensis -speciﬁc cytotoxic T cells were not
Circumnuclear Structure and Black Hole Fueling : HST / NICMOS Imaging of 250 Active and Normal Galaxies

Why are the nuclei of some galaxies more active than others? If most galaxies harbor a central massive black hole, the main difference is probably in how well it is fueled by its surroundings. We investigate the hypothesis that such a difference can be seen in the detailed circumnuclear morphologies of galaxies using several quantitatively defined features, including bars, isophotal twists, boxy and disky isophotes, and strong non-axisymmetric features in unsharp masked images. These diagnostics are applied to 250 high-resolution images of galaxy centers obtained in the near-infrared with NICMOS on HST. To guard against the influence of possible biases and selection effects, we have carefully matched samples of Seyfert 1, Seyfert 2, LINER, starburst and normal galaxies in their basic properties, taking particular care to ensure that each was observed with a similar average scale (10−15 parsecs per pixel). Several morphological differences among our five different spectroscopic classifications emerge from the analysis. The HII/starburst galaxies show the strongest deviations from smooth elliptical isophotes, while the normal galaxies and LINERS have the least disturbed morphology. The Seyfert 2 galaxies have significantly more twisted isophotes than any other category, and the early-type Seyfert 2s are significantly more disturbed than the early-type Seyfert 1s. The morphological differences between Seyfert 1s and 2s suggest that more is at work than simply the viewing angle of the central engine. They may correspond to different evolutionary stages.
ADVANCES Fast Track Aortic Surgery: Why Not?

: We investigated the effects of the introduction of fast track aortic surgery in a vascular department. Methods. We conducted an 11 years retrospective analysis. We analyzed data from 2000 to 2010 on 758 patients undergoing elective open aortic surgery with a fast track pathway: minimally invasive surgery and anesthesia, early oral feeding and ambulation. This pathway inevitably inﬂuenced all patients pathways inside the department. We analyzed data of the whole department activity from 2003 to 2010. The mortality rate after aortic surgery was 1.98%, the morbidity rate 6.59% and the median postoperative length of stay 3 days. An overall analysis of the department performance underlined a progressive reduction in the mean hospital stay (8.18 in 2003 and 4.54 in 2010). This led to an increased turnover of patients and therefore to a rise of patients treated per year (756 in 2003 and 1070 in 2010), and to an increase of the economic reimbursement of about 40%. We met major internal obstacles, which led to an almost complete replacement of surgeons and nurses. There were neither economic nor image incentives for the team. There was no sponsorship by the local administration, which led to problems with the reimbursement from the Regional Health Service. The introduction of fast track aortic surgery has positively inﬂuenced the outcomes of patients treated for aortic diseases and the whole department performance. This revolution still meets considerable obstacles related to clinicians and administrators cultural shift.
From the student’s paper to the teacher’s computer

— From the first parchments to the present, paper is a constant in the history. The importance of handwritten notes are similar and it is a constant during centuries. Pen and paper are still the main tools used by pupils in class for several good reasons: pen and paper are cheap, flexible, easy to use, and not distractive. But with the irruption of smartpens in the technological market, the vision of the handwriting in educational systems can change. These devices allow students to take notes or draw schemes while simultaneously recording classroom lectures or discussion. And, at the same time of the handwriting or later, all drawings, sentences, calculations, and what student has done with his smartpen can be sent to the teacher’s computer and saved in a file. We present a comparison of technologies and characteristics to be used in a classroom.
Using QTL results to discriminate among crosses based on their progeny mean and variance

In order to develop inbred lines, parents are crossed to generate segregating populations from which superior inbred progeny are selected. The value of a particular cross thus depends on the expected performance of its best progeny, which we call the superior progeny value. Superior progeny value is a linear combination of the mean of the cross’s progeny and their standard deviation. In this study we specify theory to predict a cross’s progeny standard deviation from QTL results and explore analytically and by simulation the variance of that standard deviation under different genetic models. We then study the impact of different QTL analysis methods on the prediction accuracy of a cross’s superior progeny value. We show that including all markers, rather than only markers with significant effects, improves the prediction. Methods that account for the uncertainty of the QTL analysis by integrating over the posterior distributions of effect estimates also produce better predictions than methods that retain only point estimates from the QTL analysis. The utility of including estimates of a cross’s among-progeny standard deviation in the prediction increases with increasing heritability and marker density but decreasing genome size and QTL number. This utility is also higher if crosses are only envisioned among the best parents rather than among all parents. Nevertheless, we show that among crosses the variance of progeny means is generally much greater than the variance of progeny standard deviations, restricting the utility of estimates of progeny standard deviations to a relatively small parameter space. phenotypic values and marker information of the simulated RIL population genome-wide Bayesian shrinkage model proposed implemented Two chains were run, and after 5,000 burn-in iterations, 1,000 MCMC samples were thinned from a total of 20,000 iterations. Each sample consisted of the predicted genetic effects associated with all markers covering the genome. These data were used to obtain estimators of the superior progeny. For each estimator involving the among-progeny variance, the estimator was calculated for selection intensities of 20%, 15%, 10%, 5%, 2%, and 1%. Values of the standardized selection differential i corresponding to these intensities were calculated assuming progeny values were normally distributed. Six estimators were
Algebro-Geometric Solution to Two New （2＋1）-Dimensional Modified Kadomtsev-Petviashvili Equations

二新(2+1 ) 维的修改 Kadomtsev-Petviashvili (mKP ) 方程被介绍，它与一个层次有关(1+1 ) 维的 soliton 方程。 通过宽松的对和 Riemann-Jacobi 倒置技术的 thenonlinearization，两个的 algebro-geometricsolutions mKP 方程被获得。
SKINTIMACY TOUCH AS DIGITAL INTERACTION AND THE EXPLORATION OF INTIMACY

Skintimacy is an interface that allows for the collaborative manipulation of electronic-based processes through touch. Depending on skin contact, movement and duration of touch, digital and electronic setups can be inﬂuenced and controlled. In order to provide diverse opportuni-ties for a playful control of audio, video, motors and other forms of output, a microcontroller is being employed to transfer data to software platforms. This sensor, acting as both a research tool and DIY kit (www.skintimacy.org, 2013), is intended to facilitate the symbolic relationship between physical computing and the sense of touch. The straightforward design of the device allows for experimentation in many different contexts. Taking into account the dynamic nature of skin conductivity, which varies individually, one has the possibility to create highly responsive installations. In the ﬁrst part of the workshop we will introduce the participants to haptic and touch-based interfaces, describe our intentions, the qualities and technical characteristics of the Skintimacy kit. In the second part, we will practically conceptualize and design interactive scenarios with the skin-based sensor in order to experience interpersonal touch as digital interaction and its inﬂuence on intimacy and personal boundaries. A common discussion on the potentials and limitations of skin-based and ”techno-organical” interfaces will close the session.
Tumor-associated macrophages increase COX-2 expression promoting endocrine resistance in breast via the PI3K/Akt/mTOR pathway

(ER)-positive Our previous study has shown that tumor-associated macrophages (TAMs) are associated with endocrine resistance, yet the mechanism remains unclear. This is dedicated to discuss the role of TAMs in the endocrine resistance of breast cancer. It was found that MCF-7 cells induced more macrophages polarized into TAMs. Conversely, (COX-2)/prostaglandin E2 (PGE2), tamoxifen resistance through the activation of the PI3K/Akt/mTOR signa ling pathway in MCF-7 five-year progression-free cancer these show a positive feedback loop between TAMs and COX-2 may be new therapeutic targets for breast cancer patients suffer from endocrine resistance.
Free Magazines: A Successful Business Model Innovation for Print Publishing in Thailand

Although the overall advertisement revenue in Thailand has declined in the print magazine industry and the number of magazine titles has significantly fallen over the years due to internet disruption, free-copy magazines have continuously re-mained profitable. Most above-normal performance of free-copy magazines is due to a multi-sided platform of resource-based view (RBV) which is structured in the business model innovation developed by Osterwalder & Pigneur (2009). This model relies heavily on mass distribution within a city. The research investigates and analyses above-normal performance in the free-copy magazine sector using the multi-sided business platform to propose the best practice business models.
Cooperative Global Adaptive Output Regulation for Nonlinear Uncertain Multi‐Agent Systems with IISS Inverse Dynamics

The cooperative global adaptive output regulation of nonlinear multi‐agent systems with unity relative degree was studied recently for the case where the inverse dynamics of the follower subsystems are input‐to‐state stable (ISS). In this paper, we present a further result by relaxing the ISS assumption to the integral ISS (iISS) assumption. As the iISS condition is strictly weaker than the ISS condition, our result applies to a larger class of nonlinear multi‐agent systems.
Early Detection of Ransomware Exploits Using Snort

 Abstract - We live in a fast-evolving internet age where opportunities are limitless, but so are the risks and chances of security breaches. In 2017, ‘ The Shadow Brokers ’ , a self-proclaimed group of hackers, released several hacking tools and zero day exploits from the intelligence arsenal of USA ’ s National Security Agency (NSA). Chief amongst these exploits were - Eternal Blue, Eternal Romance, Eternal Synergy and Eternal Champion. These, along with Eternal Red, were collectively titled the ‘ Eternal Series Exploits ’ . These exploits were subsequently used to make potential cyber weapons like ‘ WannaCry ’ , ‘ Petya ’ and ‘ NotPetya ’ ransomware, which affected lakhs of computers worldwide and exposed major vulnerabilities in Microsoft Windows. In this age, where hackers constantly devise new methods to infiltrate systems, it is imperative to safeguard and strengthen network security by anticipating data breaches and providing protection from potential hazards. Deploying simple firewalls can no longer ensure adequate security. The need of the hour is an intrusion detection system like Snort, which analyses network traffic to detect potentially malicious activity and issues alerts. Such a system provides an additional defence mechanism and is an indispensable part of any security framework. Through this project, we aim to configure new Snort rules to successfully detect the Eternal exploits (and other similar exploits) in real time, so that no user data is compromised.
Biotechnological Applications of Plastid Foreign Gene Expression Biotechnological Applications of Plastid Foreign Gene Expression

Chloroplast is responsible for the major metabolic process photosynthesis. These organ- elles have their own genome and in the last three decades, the chloroplast genome has been broadly studied and manipulated through genetic engineering tools. The transfer of genes into chloroplast provides advantage over the insertion of transgene into nuclear genome, including overexpression of foreign protein, no positional effects, absence of epigenetic effects and uniparental inheritance of the transgenes, the ability to express multiple transgenes in operons and the possibility of eliminate the marker gene after the transformation and integration of the foreign gene. Now more than 100 transgenes have been reported stably integrated into the chloroplast genome including genes encoding enzymes with industrial value, biomaterials, biopharmaceuticals, vaccines and genes with agronomic trails. The chloroplast genetic tools have been implemented in several important crops. So, the chloroplast engineering technology has been positioned as the most important for the production of proteins and metabolites with biotechnological applications.
STUDYING THE OCCURRENCE OF CLUMPING FACTOR GENE IN STAPH AUREUS ISOLATED FROM CASES OF SUBCLINICAL MASTITIS AND THE EFFECT OF SUCH PATHOGEN ON MILK COMPOSITION

120 milk samples (represent 35 cows) were randomly collected from different small holder farms, firstly tested for subclinical mastitis by CMT. 38 CMT positive samples were subjected for conventional methods of isolation and identificacion of Staph aureus . 6 isolates of Staph aureus were isolated which were subjected for genotypical characterization for the presence of clumping factor and coagulase genes by PCR assay using oligonucleotide primers that amplified genes encoding cluming factor ( clfa )gene, and ( coa )gene. The results of PCR assay revealed that 5 isolates of Staph aureus were positive for coagulase gene, while 2 isolates were positive for clumping factor gene. The chemical analysis of milk showed that there were significant statistical increase in total whey protein, albumin, sodium and chloride in cows' milk samples with subclinical mastitis. While, there was a significant decrease in both calcium, phosphorous and potassium levels in comparing with the normal milk. The present study was carried out to study the presence of some virulence factors genes in Staph aureus isolated from bovine subclinical mastitis which is very important prerequisites for implementation of effective control programs to face the economic losses due to subclinical mastitis caused by this microorganism.
64 Stage Ropufs GDS2 for Device Authentication and Secret Key Generation

: Ring Oscillator Physical Unclonable Functions (RO-PUFs) are innovative circuit primitives that extract secrets from physical characteristics of integrated circuits (ICs). We present RO-PUFs designs that exploit inherent delay characteristics of transistors that differ from chip to chip and describe RO-PUFs which can enable low-cost authentication of individual ICs and generate volatile secret keys for cryptographic operations. In this paper a 64 stage ring oscillator is implemented using the 250nm CMOS technology provided by generic with 2.5 volt power supply. The optimization design is done using Hiper-Silicon software to make the RO-PUFs as small as possible. In, addition Tanner tools 16.5v is used in the analysis and simulation to verify the predicted performance. The proposed design is suitable for DCO and Timer circuits.
L'Evolution des Galaxies Infrarouges: des observations cosmologiques avec ISO à une modélisation de l'infrarouge moyen au submillimétrique

Cette these a pour objet d'une part l'analyse du releve profond firback effectue par l'infrared space observatory dans l'infrarouge lointain a 170 microns de longueur d'onde, qui a pour but d'etudier les galaxies contribuant au fond extragalactique infrarouge, et d'autre part la modelisation de l'evolution des galaxies dans le domaine spectral s'etendant de l'infrarouge moyen au submillimetrique. Le releve firback consiste en 3 champs (deux boreaux et un austral) a haute latitude galactique et de faible emission d'avant-plan, couvrant une surface totale de 4 degres carres. J'expose tout d'abord les techniques de reduction, de traitement et d'etalonnage des donnees cosmologiques isophot. En particulier, je montre qu'en ayant determine le lobe de l'instrument, l'emission etendue est en accord entre phot et dirbe. Les cartes finales sont construites, et le releve est limite par la confusion (sigma = 40 mjy). Je presente ensuite les techniques d'extraction des sources et de simulation pour la photometrie, qui permettent de construire le catalogue final de 86 sources, de flux compris entre 200 mjy (5 sigma) et 2 jy. Le catalogue complementaire regroupe 147 sources de flux compris entre 120 et 200 mjy. Les comptages de galaxies presentent un fort exces par rapport aux modeles sans et avec evolution, et aux observations locales : ils ne sont compatibles qu'avec des scenarii de forte evolution. Les sources representent 5% du fond extragalactique a 170 microns. Les quelques identifications a d'autres longueurs d'onde (en particulier dans le domaine visible et submillimetrique) suggerent que les sources firback sont des galaxies tres lumineuses dont la majorite est locale, mais dont une fraction non negligeable se situe a des redshifts superieurs a 1. Dans le but de comprendre la nature des sources firback et d'apporter des contraintes sur l'evolution des galaxies infrarouges, j'ai developpe un modele phenomenologique d'evolution. En utilisant la fonction de luminosite locale observee et une famille de spectres de galaxies starburst, il est possible de contraindre l'evolution de la fonction de luminosite en ajustant toutes les donnees existantes : comptages profonds a 15, 170 et 850 microns et spectre du fond extragalactique. Je montre ainsi que l'evolution des galaxies dans le domaine couvrant l'infrarouge moyen au submillimetrique est dominee par une population de galaxies infrarouges ultra-lumineuses, dont le pic se situe a l = 2. 0 10 11 luminosites solaires. Les distributions en redshift sont en accord avec les observations. Le modele permet de faire des predictions pour les futures observations spatiales de sirtf, planck et first.
Improvement of Time Series Forecasting Using Genetic-Neural Hybrid Architecture

Time series forecasting has been applied to different applications. Artificial neural networks (ANNs) have widely usage in developing time series forecasting models, too. In this paper, an evolutionary neural network model is proposed to improve the performance of ANNs in time series forecasting. In this way, the genetic algorithm (GA) is used to determine the optimum structure and parameters of ANN, such as the number of hidden nodes, the slope of nodes’ activation function, the values of learning rate and momentum coefficient in hidden and output layers, and the number of input features. To evaluate the effectiveness of the proposed model, foreign exchange rate (FOREX) prediction, as a benchmark application, is performed in this paper. Empirical results show that by using suitable operators for selection and crossover in GA, the mean squared error (MSE) of the proposed evolutionary-connectionist hybrid model reaches 0.0010, which is a better performance compared to some other algorithms.
Finite Markov Chains and Algorithmic Applications: Simulated annealing

1. Basics of probability theory 2. Markov chains 3. Computer simulation of Markov chains 4. Irreducible and aperiodic Markov chains 5. Stationary distributions 6. Reversible Markov chains 7. Markov chain Monte Carlo 8. Fast convergence of MCMC algorithms 9. Approximate counting 10. Propp-Wilson algorithm 11. Sandwiching 12. Propp-Wilson with read once randomness 13. Simulated annealing 14. Further reading.
Cosmology within Noncommutative Spectral Geometry

Close to the Planck energy scale, the quantum nature of space-time reveals itself and all forces, including gravity, should be unified so that all interactions correspond to just one underlying symmetry. In the absence of a full quantum gravity theory, one may follow an effective approach and consider space-time as the product of a four-dimensional continuum compact Riemanian manifold by a tiny discrete finite noncommutative space. Since all available data are of a spectral nature, one may argue that it is more appropriate to apply the spectral action principle in this almost commutative space. Following this procedure one obtains an elegant geometric explanation for the most successful particle physics model, namely the standard model (and supersymmetric extensions) of electroweak and strong interactions in all its details, as determined by experimental data. Moreover, since this gravitational theory lives by construction at very high energy scales, it offers a perfect framework to address some of the early universe cosmological questions still awaiting for an answer. After introducing some of the main mathematical elements of noncommutative spectral geometry, I will discuss various cosmological and phenomenological consequences of this theory, focusing in particular on constraints imposed on the gravitational sector of the theory.