Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of bouncing the barbell in bench press on throwing velocity and strength among handball players

Bench press is a popular training-exercise in throw related sports such as javelin, baseball and handball. Athletes in these sports often use bouncing (i.e., letting the barbell collide with the chest) to create an increased momentum to accelerate the barbell upwards before completing the movement by throwing the barbell. Importantly, the effects of the bouncing technique in bench press have not been examined. Therefore, the aim of this study was to compare the effects of bench press throw with (BPTbounce) or without bounce (BPT) on throwing velocity (penalty and 3-step), 1-repetition maximum (1-RM) and average power output (20-60kg) in bench press among handball players. Sixteen male amateur handball players (7.1±1.9 years of handball experience) were randomly allocated to an eight-week supplementary power training program (2 x week-1) with either the BPT or BPTbounce. Except for the bounce technique, the training programs were identical and consisted of 3 sets with 3–5 repetitions at 40–60% of 1-RM with maximal effort in free-weight barbell bench press throw. The results revealed no significant differences between the groups in any of the tests (p = 0.109–0.957). However, both groups improved penalty throw (BPT; 4.6%, p<0.001, ES = 0.57; BPTbounce; 5.1%, p = 0.008, ES = 0.91) and 1-RM (BPT; 9.7%, p<0.001, ES = 0.49; BPTbounce; 8.7%, p = 0.018, ES = 0.60), but only the BPT improved the 3-step throw (BPT; 2.9%, p = 0.060, ES = 0.38; BPTbounce; 2.3%, p = 0.216, ES = 0.40). The BPT improved power output only at 20kg and 30kg loads (9.1% and 12.7%; p = 0.018–0.048, ES = 0.43–0.51) whereas BPTbounce demonstrated no significant differences across the loads (p = 0.252–0.806). In conclusion, the bounce technique demonstrated similar effects on throwing velocity, muscle strength and muscle power output as conventional bench press throw without the bounce technique.
Authentication for secure environments based on iris scanning technology

Identification and verification of authorised users in a military context can sometimes be a matter of life or death and it is therefore essential that systems be accurate, reliable and robust. The need for positive identification of users in a military context is well recognised. The use of passwords or passphrases comprising of multiple words has the potential for compromise. The need for different passwords for different systems, together with the requirement to change the passwords at regular intervals often exacerbates the problem, particularly when systems are used infrequently or are widely dispersed. It is widely accepted that recollection of long passwords is challenging within the office environment; failure to recollect multiple passwords within the stressful battlefield environment could increase the risk of critical systems failure. The cost of management of forgotten passwords, lost or stolen tokens and smartcards, coupled with the decreasing cost of biometric equipment within the past five years, has meant that biometric technologies are now a viable consideration. The ability to recall randomly generated n-digit passwords in the field compared with the use of visual biometrics for the purposes of authentication makes the latter a preferable alternative. Various biometric technologies have been considered for use within the military, including facial recognition, iris scanning, finger scanning, and voice verification. Iris scanning was deemed to be the most suitable current biometric technology to meet battlefield requirements due to the wide variety of environments in which the military operate, and the equipment and clothing that they are required to wear for protection, e.g. NBC suits, flash masks, oxygen masks etc.; an iris scanning system has already been piloted in the UK.
Pazopanib-induced severe acute liver injury

Abstract Rationale: Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the United States. Painkillers and fever antipyretics are the most common cause of DILI. Hepatic injury can be provoked by DILI as hepatocellular or cholestatic type. Patient concerns: A 48-year-old woman presented jaundice accompanied by nausea and vomiting. The patient was an inactive hepatitis B carrier with low viral titer and was diagnosed renal cell carcinoma (RCC) with hepatic metastasis requiring pazopanib treatment. Prior to administration of pazopanib, tenofovir administration was started to prevent exacerbation of hepatitis B. The patient was referred to clinic of gastroenterology department due to sudden elevation of bilirubin after 5 weeks of pazopanib treatment. Diagnoses: Abdominal ultrasound and computed tomography showed non-specific finding other than metastatic nodule in the liver and liver cirrhosis. After then, the patient was performed liver biopsy, and the biopsy result was acute cholestatic hepatitis with centrilobular area necrosis and portal inflammation. Therefore, considering the clinical history and biopsy results, the patient was diagnosed as DILI due to pazopanib. Interventions: After the biopsy, empirical steroid therapy was initiated and after 7 weeks of pazopanib discontinuation. Outcomes: The total bilirubin level returned to normal from peak level of 24.61 to 1.52 mg/dL. Lessons: In patients with renal cell carcinoma, pazopanib treatment requires clinical caution as it causes rare complications such as severe jaundice and acute cholestatic hepatitis.
‘They eat it like sweets’: A mixed methods study of antibiotic perceptions and their use among patients, prescribers and pharmacists in a district hospital in Kabul, Afghanistan

Background Antibiotic resistance is a growing public health threat. In Afghanistan, high levels of indiscriminate antibiotic use exist, and healthcare programmes are not informed by understanding of local attitudes towards rational antibiotic use. Médecins Sans Frontières is an international non-governmental organization providing healthcare services to the Ahmad Shah Baba (ASB) District Hospital in Kabul, Afghanistan, since 2009. This mixed-methods study aimed to explore the perceptions and attitudes toward antibiotics among patients, prescribers, and pharmacists in the ASB District hospital outpatient department. Methods and findings Knowledge of antibiotics including their purpose and function, how and why they are used, and drivers for choice of antibiotic was examined at patient, prescriber, and provider-level. The first phase of the study, an exploratory qualitative component using an interpretative approach, was used to inform the second phase, a structured survey. Thirty-six interviews were conducted with 39 participants (21 patients or caretakers and 18 hospital health workers). Three hundred and fifty-one (351) patients and caretakers completed the second phase, the structured survey. This study found that poor knowledge of antibiotics and antibiotic resistance is a driving factor for inappropriate use of antibiotics. Participant perceptions of living in a polluted environment drove the high demand and perceived ‘need’ for antibiotics: patients, doctors and pharmacists alike consider dirty and dusty living conditions as causes of ‘disease’ in the body, requiring antibiotics to ‘clean’ and ‘strengthen’ it. Conclusions Findings highlight the need for strategies to improve awareness and knowledge of the general public, improve practice of doctors and pharmacists, regulate antibiotic dispensing in private pharmacies, and implement antibiotic stewardship in hospitals.
The red flags of ulnar neuropathy in leprosy

The diagnosis of pure neural leprosy is more challenging because patients share characteristics with other common pathologies, such as ulnar compression, which should be taken into consideration for differential diagnosis. In this study, we identify ulnar nerve conduction characteristics to aid in the differential diagnosis of ulnar neuropathy (UN) in leprosy and that of non-leprosy etiology. In addition, we include putative markers to better understand the inflammatory process that may occur in the nerve. Data were extracted from a database of people affected by leprosy (leprosy group) diagnosed with UN at leprosy diagnosis. A non-leprosy group of patients diagnosed with mechanical neuropathy (compressive, traumatic) was also included. Both groups were submitted to clinical, neurological, neurophysiological and immunological studies. Nerve enlargement and sensory impairment were significantly higher in leprosy patients than in patients with compressive UN. Bilateral impairment was significantly higher in the leprosy group than in the non-leprosy group. Leprosy reactions were associated to focal demyelinating lesions at the elbow and to temporal dispersion (TD). Clinical signs such as sensory impairment, nerve enlargement and bilateral ulnar nerve injury associated with eletrodiagnostic criteria such as demyelinating finds, specifically temporal dispersion, could be tools to help us decided on the best conduct in patients with elbow ulnar neuropathy and specifically decide if we should perform a nerve biopsy for diagnosis of pure neural leprosy.
Elevated neuron-specific enolase level is associated with postoperative delirium and detection of phosphorylated neurofilament heavy subunit: A prospective observational study

Background Delirium is the most common central nervous system complication after surgery. Detection of phosphorylated neurofilament heavy subunit in the serum reflects axonal damage within the central cervous system and is associated with the severity of postoperative delirium. Neuron-specific enolase and S100 calcium-binding protein β have been identified as possible serum biomarkers of postoperative delirium. This study examined the association of the levels of these markers with incidence of postoperative delirium and detection of phosphorylated neurofilament heavy subunit. Methods This study represents a post hoc analysis of 117 patients who participated in a prospective observational study of postoperative delirium in patients undergoing cancer surgery. Patients were clinically assessed for development of postoperative delirium within the first five days of surgery. Serum levels of phosphorylated neurofilament heavy subunit, neuron-specific enolase, and S100 calcium-binding protein β levels were measured on postoperative day 3. Results Forty-one patients (35%) were clinically diagnosed with postoperative delirium. Neuron-specific enolase level (P < 0.0001) and the proportion of patients positive for phosphorylated neurofilament heavy subunit (P < 0.0001) were significantly higher in the group of patients with postoperative delirium. Neuron-specific enolase level discriminated between patients with and without clinically diagnosed postoperative delirium with significantly high accuracy (area under the curve [AUC], 0.87; 95% confidence interval [CI], 0.79–0.95; P < 0.0001). Neuron-specific enolase level was associated with incidence of postoperative delirium independently of age (adjusted odds ratio, 8.291; 95% Cl, 3.506−33.286; P < 0.0001). The AUC for the serum neuron-specific enolase level in detecting phosphorylated neurofilament heavy subunit was significant (AUC, 0.78; 95% CI, 0.66–0.90; P < 0.0001). Conclusion Elevated serum neuron-specific enolase was associated with postoperative delirium independent of age as well as detection of phosphorylated neurofilament heavy subunit in serum. Serum neuron-specific enolase and phosphorylated neurofilament heavy subunit might be useful as biomarkers of postoperative delirium. Trial registration University Medical Information Network (UMIN) trial ID: UMIN000010329; https://clinicaltrials.gov/.
Making asset investment decisions for wastewater systems that include sustainability

Effective integrated water management is a key component of the World Water Vision and the way in which aspirations for water equity may be realized. Part of the vision includes the promotion of sustainability of water systems and full accountability for their interaction with other urban systems. One major problem is that “sustainability” remains an elusive concept, although those involved with the provision of urban wastewater systems now recognize that decisions involving asset investment should use the “triple bottom line” approach to society, the economy, and the environment. The Sustainable Water Industry Asset Resource Decisions project has devised a flexible and adaptable framework of decision support processes that can be used to include the principles of sustainability more effectively. Decision mapping conducted at the outset of the project has shown that only a narrow range of criteria currently influence the outcome of asset investment decisions. This paper addresses the concepts of sustainab.
Introduction to the environmental impact of construction and building materials

Abstract: Earth’s natural resources are finite and face increasing human pressure. Over the last few decades, concern has been growing about resource efficiency and the environmental impact of material consumption. The construction industry is responsible for the consumption of a relevant part of all produced materials, however, only recently has this industry started to worry about its environmental impacts. This chapter highlights relevant landmarks on sustainable development, materials efficiency and on the assessment of the environmental impact of construction products. An overview on the European Construction Products Regulation (CPR) enforced since the 1 July 2013 is given followed by an outline of the book.
Epigenomic signatures in age-related macular degeneration: Focus on their role as disease modifiers and therapeutic targets

Epigenetics is characterized by molecular modifications able to shape gene expression profiles in response to inner and external stimuli. Therefore, epigenetic elements are able to provide intriguing and useful information for the comprehension and management of different human conditions, including aging process, and diseases. On this subject, Age-related Macular Degeneration (AMD) represents one of the most frequent age-related disorders, dramatically affecting the quality of life of older adults worldwide. The etiopathogenesis is characterized by an interplay among multiple genetic and non-genetic factors, which have been extensively studied. Nevertheless, a deeper dissection of molecular machinery associated with risk, onset, progression and effectiveness of therapies is still missing. In this regard, epigenetic signals may be further explored to disentangle disease etiopathogenesis, the possible therapeutic avenues and the differential response to AMD treatment. This review will discuss the epigenomic signatures mostly investigated in AMD, which could be applied to improve the knowledge of disease mechanisms and to set-up novel or modified treatment options.
Chronische Pankreatitis: Update Diagnostik und Therapie

Zusammenfassung Hintergrund Die chronische Pankreatitis (CP) ist eine häufige Ursache für stationäre Einweisungen in die Gastroenterologie und ist mit einer reduzierten Lebensqualität und Lebenserwartung assoziiert. Die Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselerkrankungen (DGVS) hat in der aktuellen S3-Leitlinie „Pankreatitis“ die neuesten Erkenntnisse von Epidemiologie, Diagnostik und Behandlung der akuten und chronischen Pankreatitis zusammengefasst. Hier werden praxisrelevante Aspekte für die chronische Pankreatitis zusammengefasst. Ergebnisse Die häufigste Ursache der CP ist der chronische Alkoholabusus. Weitere Ursachen sind die hereditäre Pankreatitis, die Autoimmunpankreatitis, ein Hyperparathyreoidismus und idiopathische Formen der CP. Neben der klassischen hereditären Pankreatitis (PRSS1-Mutation), sind in den letzten Jahren eine Vielzahl an Genen identifiziert worden, die mit einem erhöhten Risiko für die Entwicklung einer idiopathischen CP assoziiert sind. In der konservativen Therapie der CP steht die Behandlung der exokrinen und endokrinen Insuffizienz sowie die Prävention und Behandlung von Sekundärkomplikationen (z.B. Osteoporose, Vitaminmangel, Mangelernährung) im Vordergrund. Lokale Komplikationen (Gallengangsstenose, Duodenalstenose, Pseudozysten und chronische Schmerzen) sollten in Pankreaszentren im interdisziplinären Konsens zwischen Viszeralchirurgie, Radiologie und der interventionellen Endoskopie abgestimmt werden. Während die Drainage von Pseudozysten die Domäne der Endoskopie ist, zeigen neueste Daten, dass die chirurgische Therapie von opiatabhängigen Schmerzen bei Patienten mit einem erweiterten Pankreasgang der Endoskopie überlegen ist. Schlussfolgerung Die CP weist eine erhöhte Morbidität und Mortalität auf und führt häufig zu stationären Krankenhauseinweisungen. Das klinische Management dieser Patienten verlangt ein hohes Maß an Interdisziplinarität, um für jeden Patienten abhängig von den Komorbiditäten und dem Erkrankungsstadium ein individualisiertes Vorsorge- und Therapiekonzept zu entwerfen.
Topical timolol in dermatology: infantile haemangiomas and beyond

Timolol, a nonselective β‐adrenergic receptor blocker, is well‐tolerated and is becoming increasingly popular in dermatology, especially in the management of infantile haemangioma (IH). Its effects are mainly due to vasoconstriction, inhibition of angiogenesis and keratinocyte migration promotion for re‐epithelialization and wound healing. We review the evidence behind the use of timolol in several dermatological conditions including IH, pyogenic granulomas, Kaposi sarcoma, chronic wound healing, postsurgical wounds, acne vulgaris, rosacea, eczema and red scrotum syndrome.
Intertriginous mycosis fungoides with T follicular helper cell phenotype progressing to Sézary syndrome

The diagnosis of the most common cutaneous T-cell lymphomas (CTCLs), mycosis fungoides (MF) and Sézary syndrome (SS) are often delayed because of unspecific clinical and histopathological findings in the early stages of the disease.1 In SS, erythroderma is considered an important diagnostic criterion; however, it is not always the presenting feature.2 Secondary SS refers to a diagnosis of SS following established MF3 ; whereas, pre-SS refers to erythroderma with a sézary cell count of less than 1000 cells/mm4 . To date, cutaneous manifestations which precede the development of confluent erythroderma include lesions suggestive of non-specific dermatitis, patches and plaques of MF, and urticaria2 which challenge the historical clinical tenet. Here, we present one patient who developed confluent erythroderma with a sézary cell count of less than 1000 cells/mm following an initial presentation of intertriginous lesions.
The E3 ubiquitin ligase adaptor Tango10 links the core circadian clock to neuropeptide and behavioral rhythms

Significance In animals, the control of daily sleep–wake rhythms is mediated by discrete circadian clock neurons via their rhythmic activity–dependent release of neuropeptides and neurotransmitters. Here, we describe a gene, Tango10, critical for daily behavioral rhythms. TANGO10 functions as an adaptor with its partner, the E3 ubiquitin ligase CULLIN 3, to regulate protein ubiquitination, neuronal excitability via voltage-gated potassium channels, and neuropeptide accumulation. These studies define a mechanism for control of neuronal excitability and daily rhythmicity. Circadian transcriptional timekeepers in pacemaker neurons drive profound daily rhythms in sleep and wake. Here we reveal a molecular pathway that links core transcriptional oscillators to neuronal and behavioral rhythms. Using two independent genetic screens, we identified mutants of Transport and Golgi organization 10 (Tango10) with poor behavioral rhythmicity. Tango10 expression in pacemaker neurons expressing the neuropeptide PIGMENT-DISPERSING FACTOR (PDF) is required for robust rhythms. Loss of Tango10 results in elevated PDF accumulation in nerve terminals even in mutants lacking a functional core clock. TANGO10 protein itself is rhythmically expressed in PDF terminals. Mass spectrometry of TANGO10 complexes reveals interactions with the E3 ubiquitin ligase CULLIN 3 (CUL3). CUL3 depletion phenocopies Tango10 mutant effects on PDF even in the absence of the core clock gene timeless. Patch clamp electrophysiology in Tango10 mutant neurons demonstrates elevated spontaneous firing potentially due to reduced voltage-gated Shaker-like potassium currents. We propose that Tango10/Cul3 transduces molecular oscillations from the core clock to neuropeptide release important for behavioral rhythms.
Why do African–American men face higher risks for lethal prostate cancer?

Purpose of review African–American men in the USA have a higher incidence of and mortality from prostate cancer (PCa), with a longstanding debate about the cause for these worse outcomes. This review examines differences in tumour biology and socioeconomics for African–American and Non-Hispanic White (NHW) men to answer the question ‘why AA men face higher risks for lethal PCa’ and draw a management consensus to redress the imbalance. Recent findings Recent evidence from over the past 2 years suggests the reasons why African–American men face a higher risk of lethal PCa are multifactorial, with contributions from differences in tumour biology as well as socioeconomic and healthcare access factors. Regarding tumour biology, genomic and transcriptome profiling suggests African–American men have upregulated expression of genes related to inflammatory pathways with downregulation of DNA repair genes. In contrast, NHW men have higher DNA repair pathways and metabolic pathways involving glycolysis and cell cycle activity. In addition, epidemiological evidence suggests equal healthcare access ensures equal PCa specific outcomes, implying African–American men's disease is not inherently more lethal. However, differences in tumour biology remain, which may explain specific differences in PCa incidence and the clinical findings of African–American men's increased response to immunotherapy and radiotherapy in recent trials. Summary Regardless of racial differences in disease outcomes and the factors causing them, African–American and NHW men seem to have diseases unique to their ancestry. This supports the exploration of personalized PCa treatment approaches, leveraging translational basic science research to uncover these differences and devise specific individualized methods therapeutic regimes to address them.
Further Advances on B.V.A. Quartz Resonators

In the 1976 and 1977 Annual msia on Frequency Cmtrol a new piezo-electric resonator desicp was introduced. The recent results on 5 WIZ resamtors ccnceming anplitude frequency effect , aging (versus drive level and quartz material) will be given. Especially it will be shown that extrenely high drive levels can be used (up to 30 m) and that the increase in drive level
A comparison of patch testing with nickel sulfate in TRUE Test and in petrolatum at 2.5% and 5% concentrations

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