Miracle-dz/UniFAR-FTUs huggingface dataset:
Maximizing the Diversity of Exposure in Online Social Networks by Identifying Users with Increased Susceptibility to Persuasion

Individuals may have a range of opinions on controversial topics. However, the ease of making friendships in online social networks tends to create groups of like-minded individuals, who propagate messages that reinforce existing opinions and ignore messages expressing opposite opinions. This creates a situation where there is a decrease in the diversity of messages to which users are exposed (diversity of exposure). This means that users do not easily get the chance to be exposed to messages containing alternative viewpoints; it is even more unlikely that they forward such messages to their friends. Increasing the chance that such messages are propagated implies that an individuals’ susceptibility to persuasion is increased, something that may ultimately increase the diversity of messages to which users are exposed. This article formulates a novel problem which aims to identify a small set of users for whom increasing susceptibility to persuasion maximizes the diversity of exposure of all users in the network. We study the properties of this problem and develop a method to find a solution with an approximation guarantee. For this, we first prove that the problem is neither submodular nor supermodular and then we develop submodular bounds for it. These bounds are used in the Sandwich framework to propose a method which approximates the solution using reverse sampling. The proposed method is validated using four real-world datasets. The obtained results demonstrate the superiority of the proposed method compared to baseline approaches.
Health care system efficiency in otolaryngological surgeries during COVID-19 pandemic in years 2020-2021 compared to years 2018-2019: data from the Military Institute of Medicine in Warsaw.

Introduction: Coronavirus disease 19 (COVID-19) pandemic had a great impact on the health care system. This resulted not only from changes in the way medical facilities operated but also from the need to treat a huge number of patients. On the other hand, uninfected people feared visiting the doctor. Aim: The aim of the study was to assess the impact of the COVID-19 pandemic on the diagnostics and treatment of patients with head and neck cancer. Materials and methods: This retrospective study involved analysis of data of patients from a single hospital unit who underwent surgical procedures due to head and neck cancer during the COVID-19 pandemic in years 2020-2021 (pandemic group) compared to years 2018-2019 (pre-pandemic group). Results: Patients in the pandemic group (n = 123) were older and were more likely to have grade 3 cancer than patients in the pre-pandemic group (n = 116). Cancer stages were similar in both groups. During the pandemic, time from the first outpatient visit to surgery was longer (median 1.6 vs. 0.8 months), while time to radiotherapy was shorter (median 50.5 vs. 63 days) than in the pre-pandemic period. Conclusion: During the pandemic, patients had to wait slightly longer for surgery but not for radiotherapy when compared with the pre-pandemic period. Despite this, they did not have more advanced disease.
What Your Next Check-in Might Look Like: Next Check-in Behavior Prediction

In recent years, the next-POI recommendation has become a trending research topic in the field of trajectory data mining. For protection of user privacy, users’ complete GPS trajectories are difficult to obtain. The check-in information posted by users on social networks has become an important data source for Spatio-temporal Trajectory research. However, state-of-the-art methods neglect the social meaning and the information dissemination function of check-in behavior. The social meaning is an important reason why users are willing to post check-in on social networks, and the information dissemination function means, users can affect each other’s behavior by check-ins. The above characteristics of the check-in behavior make it different from the visiting behavior. We consider a new problem of predicting the next check-in behavior including the check-in time, the POI (point-of-interest) where the check-in is located, functional semantics of the POI, and so on. To solve the proposed problem, we build a multi-task learning model called DPMTM, and a pre-training module is designed to extract dynamic social semantics of check-in behaviors. Our results show that the DPMTM model works well in the check-in behavior problem.
Context-dependent function of the transcriptional regulator Rap1 in gene silencing and activation in Saccharomyces cerevisiae

Significance The coarse partitioning of the genome into regions of active euchromatin and repressed heterochromatin is an important, and conserved, level of gene expression regulation in eukaryotes. Repressor Activator Protein (Rap1) is a transcription factor that promotes the activation of genes when recruited to promoters, and aids in the establishment of heterochromatin through interactions with silencer elements. Here, we investigate the role of Rap1 when bound to a promoter in silent chromatin and dissect the context-specific epigenetic cues that regulate the dual properties of this transcription factor. Together, our data highlight the importance of protein–protein interactions and local chromatin state on transcription factor function.
Survivorship Care in Middle-Income Countries: A Guideline Development for Colombia Using Breast Cancer as a Model

Cancer survival has significantly increased during the past few decades, making survivorship care a key element of cancer control and posing several challenges for long-term care in low- and middle-income countries (LMIC). Most survivorship care guidelines emphasize the potential role of primary care physicians and the need for comprehensive care, with a preference for patient-centered over disease-centered approaches. However, guidelines developed in high-income countries are not always suitable for LMIC, where a shortage of oncology workforce, deficient training in primary care, and low access to comprehensive centers frequently induce undertreatment and a lack of follow-up. Despite universal health insurance coverage, Colombia has fragmented cancer care with deficient survivorship care, given its focus on relapse surveillance without integration of supportive care and comorbidity management, in addition to unequal access for low-income populations and distant regions. Using the breast cancer framework, we describe the development of a guideline for survivorship care on the basis of a risk approach and the proper integration of oncology specialists and family physicians. We used a three-phase process to develop recommendations for disease control (disease-centered review), interventions aimed at improving patients' quality of life (patient-centered review), and care delivery (delivery model review). We deem our proposal suitable for middle-income countries, which represents an input for more standardized survivorship care in these settings.
Whole-genome sequence of Haemophilus parainfluenzae EL1 isolated from healthy supragingival plaque

ABSTRACT Haemophilus parainfluenzae is a Gram-negative bacterium that colonizes the mouth and the upper respiratory tract. Here, we report the genome sequence of H. parainfluenzae strain EL1 isolated from healthy supragingival plaque. This strain is used as a representative commensal of the oral microbiota.
Immunogenicity of tetanus, diphtheria and acellular pertussis vaccination among pregnant women living with and without HIV

Objective: Vaccination during pregnancy with tetanus–diphtheria–acellular pertussis (Tdap) vaccine is recommended to protect the young infants against pertussis. There is a paucity of data on immune responses to Tdap in pregnant women with HIV (PWWH), and its impact on the protection of their infants has not been described. Methods: In an open label phase IV clinical trial in South Africa, we evaluated the immunogenicity and safety of Tdap in PWWH compared with HIV-uninfected women. Antigen-specific immunoglobulin G (IgG) to pertussis toxoid, filamentous haemagglutinin, pertactin, fimbriae, diphtheria and tetanus were measured by electrochemiluminescence-based multiplex assay. Results: Overall, 91 PWWH and 136 HIV-uninfected pregnant women were enrolled. All PWWH were on antiretroviral treatment and 94.5% had HIV viral loads <40 copies per millilitre. Antibody levels prevaccination were lower among PWWH compared with HIV-uninfected women for all antigens. At 1 month postvaccination PWWH compared with HIV-uninfected women had lower fold-increase and antibody concentrations for all epitopes. Also, a lower proportion of PWWH achieved ≥4-fold increase from pre to postvaccination for pertussis toxoid and pertactin, or diphtheria IgG levels ≥0.1 IU/ml and ≥1 IU/ml postvaccination. Adverse events postvaccination were similar in PWWH and HIV-uninfected. Conclusion: Tdap vaccination was safe and immunogenic. PWHW had, however, attenuated humoral immune responses, which could affect the effectiveness of protecting their infants against pertussis compared with those born to women without HIV. ClinicalTrials.gov identifier: NCT05264662
Bryophytes of the Santa Elena Peninsula and Islas Murciélago, Guanacaste, Costa Rica, with special attention to neotropical dry forest habitats

Se comunican cincuenta y cinco especies de briofitos (21 hepaticas, 34 musgos) de los bosques secos de bajura y humedos de montana en la Peninsula de Santa Elena y las Islas Murcielago, Guanacaste, Costa Rica. Mas del 50% de las especies recolectadas son de distribucion neotropical, 16% son pantropicales y 12% anfiatlanticas (America-Africa). Nueve por ciento de las especies tiene una distribucion limitada a areas que potencialmente poseen bosque seco en Mexico, Cuba y Costa Rica. Brachymenium spirifolium, Fissidens juruensis var. juruensis, F. radicans, F. yucatanensis, Gymnostomiella vernicosa y Rhodobryum grandifolium son nuevos registros de Costa Rica. Uleobryum peruvianum y Cephaloziella subtilis son nuevos registros de Centroamerica. La mayor diversidad de briofitos se encuentra por encima de 500 m de altitud, en el bosque humedo de montana de los Cerros Santa Elena, donde la mayor parte de las especies son corticolas. En los bosques secos, suelo, troncos caidos y rocas son los habitats briofiticos mas importantes.
How to sensitize the financial industry to resource efficiency considerations and climate change related risks

Increasing resource efficiency can potentially deliver important economic and environmental benefits. Many of these benefits are regularly foregone because the financial sector's capacity to adequately take the opportunities and risks arising from resource utilization and related climate change aspects into account has so far remained relatively undeveloped. Focusing on the case of Germany, a number of barriers to the inclusion of resource efficiency and climate change aspects into financial services' considerations are presented. Corresponding measures for improving the capacity of the financial sector to better integrate resource efficiency considerations and climate change related risks into its operating procedures are introduced. The measures encompass the areas of risk controlling, company reporting, institutional reporting requirements, as well as additional supporting measures.
Low-Dose Elagolix for the Treatment of Heavy Menstrual Bleeding in Patients With Uterine Leiomyomas

Elagolix 150 mg once-daily monotherapy improves heavy menstrual bleeding associated with uterine leiomyomas in premenopausal patients. OBJECTIVE: To evaluate the safety and efficacy of elagolix 150 mg once-daily monotherapy in patients with heavy menstrual bleeding associated with uterine leiomyomas. METHODS: A phase 4, randomized, double-blind, placebo-controlled, 6-month treatment study was conducted in premenopausal patients aged 18–51 years with heavy menstrual bleeding (defined as menstrual blood loss greater than 80 mL during one menstrual cycle) associated with uterine leiomyomas. Patients were randomized 2:1 to receive elagolix 150 mg once daily or placebo. The primary endpoint was reduction in menstrual blood loss volume to less than 80 mL at the final month and at least a 50% reduction in menstrual blood loss volume from baseline to the final month. RESULTS: Of 82 randomized patients, 54 received elagolix 150 mg and 28 received placebo. With elagolix, 49.4% (95% CI 35.1–63.8%) of patients met the primary endpoint, compared with 23.3% (95% CI 7.2–39.5%) of patients who received placebo (P=.035). Statistically significant differences between elagolix and placebo in mean reduction of menstrual blood loss from baseline were seen as early as month 1 (P<.05 for months 1–3 and 5). Significantly more patients receiving elagolix experienced suppression of bleeding compared with placebo (P=.036). Greater improvements were observed in the elagolix group (vs placebo) in the proportion of patients with amenorrhea, in hemoglobin concentrations, and in health-related quality of life. No serious or severe adverse events were reported for elagolix, compared with 7.1% of participants in the placebo group having serious adverse events (coronavirus disease 2019 [COVID-19] n=1, enlarged uvula n=1). Three patients (5.6%) discontinued elagolix due to adverse events. CONCLUSION: Elagolix 150 mg once-daily monotherapy significantly improved heavy menstrual bleeding associated with uterine leiomyomas compared with placebo in premenopausal patients. Treatment with elagolix 150 mg once daily was generally well-tolerated in this study, with no new safety signals. FUNDING SOURCE: AbbVie Inc. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT03886220.
Pliocene transpressional modification of depositional basins by convergent thrusting adjacent to the “Big Bend” of the San Andreas fault: An example from Lockwood Valley, southern California

The “Big Bend” of the San Andreas fault in the western Transverse Ranges of southern California is a left stepping flexure in the dextral fault system and has long been recognized as a zone of relatively high transpression compared to adjacent regions. The Lockwood Valley region, just south of the Big Bend, underwent a profound change in early Pliocene time (∼5 Ma) from basin deposition to contraction, accompanied by widespread folding and thrusting. This change followed the recently determined initiation of opening of the northern Gulf of California and movement along the southern San Andreas fault at about 6.1 Ma, with the concomitant formation of the Big Bend. Lockwood Valley occupies a 6‐km‐wide, fault‐bounded structural basin in which converging blocks of Paleoproterozoic and Cretaceous crystalline basement and upper Oligocene and lower Miocene sedimentary rocks (Plush Ranch Formation) were thrust over Miocene and Pliocene basin‐fill sedimentary rocks (in ascending order, Caliente Formation, Lockwood Clay, and Quatal Formation). All the pre‐Quatal sedimentary rocks and most of the Pliocene Quatal Formation were deposited during a mid‐Tertiary period of regional transtension in a crustal block that underwent little clockwise vertical‐axis rotation as compared to crustal blocks to the south. Ensuing Pliocene and Quaternary transpression in the Big Bend region began during deposition of the poorly dated Quatal Formation and was marked by four converging thrust systems, which decreased the areal extent of the sedimentary basin and formed the present Lockwood Valley structural basin. None of the thrusts appears presently active. Estimated shortening across the center of the basin was about 30 percent. The formerly defined eastern Big Pine fault, now interpreted to be two separate, oppositely directed, contractional reverse or thrust faults, marks the northwestern structural boundary of Lockwood Valley. The complex geometry of the Lockwood Valley basin is similar to other Tertiary structural basins in southern California, such those that underlie Cuyama Valley, the Ridge basin, and the east Ventura basin.
EGFR Mutation Detection in Brazilian Patients With Non–Small-Cell Lung Cancer: Lessons From Real-World Data Scenario of Molecular Testing

PURPOSE There is a paucity of consistent data concerning genetic mutations in Brazilian patients with lung cancer. The aim of this study was to retrospectively analyze epidermal growth factor receptor (EGFR) mutations detected in a real-world scenario using a large cohort of Brazilian patients with non–small-cell lung cancer (NSCLC). MATERIALS AND METHODS This was a cross-sectional, observational, descriptive study on the basis of a database of EGFR molecular analysis from tumor samples of patients with a confirmatory histopathological diagnosis of primary lung cancer. Specimens were collected from 2013 to 2017 and were tested using cobas, next-generation sequencing, and Sanger sequencing platforms. RESULTS A total of 7,413 tumor specimens were tested. The patients were predominantly women with a median age of 67.0 years. Patients with at least one mutation represented 24.2% of the total sample. Among the positive patients, the majority had just one mutation, but two or more simultaneous mutations were observed in 1.52% of patients. Exon 19 deletion was the most prevalent alteration in the sample (12.8%), followed by exon 21 L858R (6.9%) and exon 20 insertion (1.6%). All others were considered uncommon mutations and were observed in 18.5% of all mutated patients and 4.0% of the total sample (2.3%-18.7% depending on the sequencing method). CONCLUSION This study examined the prevalence of EGFR mutations in Brazilian patients with NSCLC using different technologies, suggesting that the type of method used, directed or nondirected against specific mutations, influences the analysis, particularly for uncommon mutations, which will be missed by mutation-specific approaches such as cobas testing. Our estimates are the largest in Latin America and are consistent with previous reports from other parts of the world. Besides the variability in methods described here as technology incorporation advances in a nonhomogeneous manner, it is probably like the real-world clinical setting Brazilian oncologists face in their daily practice.
Experimental determination of plagioclase and clinopyroxene crystal growth rates in an anhydrous trachybasalt from Mt Etna (Italy)

Plagioclase and clinopyroxene crystal growth rates were experimentally determined in an anhydrous potassic trachy-basalt lava from the 1991–93 Mt Etna eruption. Experiments were performed at atmospheric pressure, in air, at temperatures variable from 1160 to 1240 °C. Growth rates, in potassic trachybasalt to shoshonitic melts, were calculated measuring both the width of overgrowth rims on crystal seeds and the sizes of microlite crystals: they are in the order of 10 −8 cm s −1 at low under-cooling ( −9 cm s −1 at higher undercoolings. The growth rates, determined for plagioclase are three-four orders of magnitude lower than those determined for this mineral in the same lava sample by other authors under water-saturated condition. Combining experimental data on plagioclase growth rates, water solubility in trachybasalt magmas, and crystal size distributions of Etnean lavas, we modelled the final ascent of magmas from shallow reservoirs located within the basement of the volcano in correspondence with known geological discontinuities. Calculations suggest that the final ascent of magmas occurs in a time span of 1–2 h with final velocities of 0.2–0.8 m s −1 , values compatible with actual output rates observed during the quiet effusion of degassed lavas at Mt Etna.
Ancient genomic linkage couples metabolism with erythroid development

Generation of mature cells from progenitors requires tight coupling of differentiation and metabolism. During erythropoiesis, erythroblasts are required to massively upregulate globin synthesis then clear extraneous material and enucleate to produce erythrocytes1–3. Nprl3 has remained in synteny with the α-globin genes for >500 million years4, and harbours the majority of the α-globin enhancers5. Nprl3 is a highly conserved inhibitor of mTORC1, which controls cellular metabolism. However, whether Nprl3 itself serves an erythroid role is unknown. Here, we show that Nprl3 is a key regulator of erythroid metabolism. Using Nprl3-deficient fetal liver and adult competitive bone marrow - fetal liver chimeras, we show that NprI3 is required for sufficient erythropoiesis. Loss of Nprl3 elevates mTORC1 signalling, suppresses autophagy and disrupts erythroblast glycolysis and redox control. Human CD34+ progenitors lacking NPRL3 produce fewer enucleated cells and demonstrate dysregulated mTORC1 signalling in response to nutrient availability and erythropoietin. Finally, we show that the α-globin enhancers upregulate NprI3 expression, and that this activity is necessary for optimal erythropoiesis. Therefore, the anciently conserved linkage of NprI3, α-globin and their associated enhancers has enabled coupling of metabolic and developmental control in erythroid cells. This may enable erythropoiesis to adapt to fluctuating nutritional and environmental conditions.
A novel observation: effect of anionic gelatin nanoparticle on stromal cells

Abstract Biocompatible nanoparticles are very popular in health science research. Biomolecule carriers for wound healing and tissue engineering are two main applications among many others. In many instances, these structures come in direct vicinity of cells and govern cell behaviour and responses. In this study, gelatin nano/submicron structures were synthesized by binary nonsolvent aided coacervation (BNAC) method at pH ranging from 3 to 11 with an intention to employ in skin tissue regeneration. Effect of pH over morphology and the surface composition with respect to its ionic composition were studied. Further, the initial toxicity was assessed against peripheral blood mononuclear cells (PBMC). pH 7 was found to be the optimum for synthesis of gelatin nanoparticles (GNPs) with minimum particle size. Positive cell viability of 103.14% for GNPs synthesized at pH 7 was observed. It may be due to the minimum difference between cumulative negative and positive charge (CNCP) ratio of 1.19. Finally, effect of the gelatin nanoparticles over L929 mouse fibroblast cells was assessed through MTT assay. It has resulted in 122.77% cell viability.
Complete genome sequence of Edwardsiella sp. NBRC12716 isolated in 1962 from the liver of diseased eel

ABSTRACT We report the complete genome sequence of Edwardsiella sp. NBRC12716 isolated from a diseased eel in 1962. The genome consists of a single, circular chromosome 3,771,060 bp in length with 59.74% GC content and encodes 25 rRNA, 96 tRNA, and 3,182 protein-coding genes.