Miracle-dz/UniFAR-FTUs huggingface dataset:
Iron Oxide Nanoparticles: Preparation, Characterization, and Assessment of Antimicrobial and Anticancer Activity

Nanotechnology and nanoparticles (NPs) have increasingly been studied as an alternative for antibiotics because of the feasibility to be used in implantable devices both for bacterial detection and infection prevention. The low rate of resistance development against NPs because of its multiple mode of action has contributed to its increased acceptance in clinical setting. Further development of NPs and their anticancer activity against many human cancer cell lines including breast and ovarian have been documented. Fe2O3-NPs could be used for antibacterial and anticancer activity assessment. Iron oxide, apart from being available extensively and cheap, also plays a role in multiple biological processes, making it an interesting metal for NPs. The aim of the present study revolves around generation and characterization of iron oxide Fe2O3-NPs, followed by assessment of its antimicrobial and anticancer activities. Synthesis of Fe2O3-NPs was performed by hydrothermal approach, and its characterization was done by UV-visible, X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) analyses, and transmission electron microscopy (TEM). Antimicrobial activity was checked by agar diffusion assay against Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, and Candida albicans. Anticancer activity of the NPs was assessed using the human cancer cell lines including cervical carcinoma cell line (HeLa) and MCF7. The developed Fe2O3-NPs exhibited a characteristic absorption curve in the 500-600 nm wavelength range by UV-visible analysis, the XRD peaks were found to index the rhombohedral shape, and the FTIR analysis ascertained the bonds and functional groups at wavenumber from 400 to 4000 cm-1. Antimicrobial assay detected significant effect against Staphylococcus aureus and Bacillus subtilis with zones of inhibition: 21 and 22 mm, respectively. Likewise, Fe2O3-NPs show good activity towards tested fungal strain Candida albicans with zone of inhibition of 24 mm. The 2,5-diphenyl-2H-tetrazolium bromide (MTT) assay identified significant anticancer activity of the NPs against both cell lines. Our study documents the successful generation and characterization of Fe2O3-NPs having excellent antimicrobial and anticancer activities.
Enhanced Authentication Protocol for the Internet of Things Environment

The Internet of Things (IoT) is among the most promising technologies of the future, and its development has garnered attention worldwide. However, the rise of the IoT has been accompanied by a proportionate increase in security concerns regarding communication between IoT entities. Recently, Alzahrani et al. proposed an identity-based authentication and key agreement protocol for an IoT environment, wherein a physically unclonable function was employed. They claimed that their protocol can resist various types of attacks; however, after thorough analysis, we determined it to be ineffective against privileged internal attacks, physical IoT device capture attacks, stolen-verifier attacks, and known temporary information exposure attacks. To resolve these security weaknesses, we propose a new authentication and key agreement protocol. In addition, we demonstrate that the proposed protocol is provably secure in real-or-random (ROR) model and Burrows–Abadi–Needham (BAN) logic, resisting known attacks while incurring low communication and computation costs.
CEO of Me: Creating a Life That Works in the Flexible Job Age

You are the CEO of your life: you, and nobody else. You can establish the new rules that will help you achieve true balance between work and the rest of your life. And if you don't do it, nobody else will. Now is the time to take control, and this is the book that will get you there. CEO of Me is like no other "work-life balance" book you've ever seen: there are no cliches here, and no one-size-fits all solutions. Instead, Drs. Ellen Kossek and Brenda Lautsch help you identify which of six worklife "patterns" you fit into and how to move towards a pattern that's more productive and comfortable for you, one step at a time. As leaders of North America's largest research projects on work/life balance, Kossek and Lautsch are singularly well-qualified to write this book. Drawing on their unparalleled research insights, they show how to identify the personal triggers that cause you the greatest stress.make the small changes that make the biggest difference.make technology work for you, not against you.redraw the lines between work and family as your life changes.master powerful strategies for managing yourself, your colleagues, and your supervisors.leverage emerging work options that are available to our generation for the first time. The authors' radical new approach will transform the way you view both your work and your life and help you make the practical changes that lead to true fulfillment.
Bijective Differential Search Algorithm for Robust Design of Damping Controller in Multimachine Power System

Low frequency oscillation (LFO) is a serious threat to the interconnection of power system and its safe operation. In this paper, optimum damping performances over LFO is achieved by implementing Bijective Differential Search Algorithm (B-DSA) to large interconnected power system. Conventional two stages lead-lag compensator is optimized as the Power System Stabilizer (PSS) and Linear Time Invariant (LTI) State Space system models are used to conduct stability analysis of power system. The tuning problem of PSS in multimachine system was formulated as a multi-objectives function. The simulations are conducted in 5-AREA 16 Machine test power system for severe system fault in order to verify the robust design of damping controller. The obtained results are compared with standard DSA optimization technique. The findings show the improved damping achieved by B-DSA than DSA algorithm. The settling times achieved using B-DSA based designed PSSs are 3.74sec and 4.57sec for local mode and inter-area mode of oscillations respectively. The successful damping over oscillation modes of LFO justifies the proposed technique is efficient for the improvement of power system security in adverse condition.
The Longitudinal Dividing Bacterium Candidatus Thiosymbion Oneisti Has a Natural Temperature-Sensitive FtsZ Protein with Low GTPase Activity

FtsZ, the bacterial tubulin-homolog, plays a central role in cell division and polymerizes into a ring-like structure at midcell to coordinate other cell division proteins. The rod-shaped gamma-proteobacterium Candidatus Thiosymbion oneisti has a medial discontinuous ellipsoidal “Z-ring. ” Ca. T. oneisti FtsZ shows temperature-sensitive characteristics when it is expressed in Escherichia coli, where it localizes at midcell. The overexpression of Ca. T. oneisti FtsZ interferes with cell division and results in filamentous cells. In addition, it forms ring- and barrel-like structures independently of E. coli FtsZ, which suggests that the difference in shape and size of the Ca. T. oneisti FtsZ ring is likely the result of its interaction with Z-ring organizing proteins. Similar to some temperature-sensitive alleles of E. coli FtsZ, Ca. T. oneisti FtsZ has a weak GTPase and does not polymerize in vitro. The temperature sensitivity of Ca. Thiosymbion oneisti FtsZ is likely an adaptation to the preferred temperature of less than 30 °C of its host, the nematode Laxus oneistus.
Introducción al blockchain, los contratos inteligentes y su relación con el arbitraje

La transformación digital avanza a pasos agigantados. En este escenario, la cadena de bloques, también llamada blockchain, se ha posicionado exitosamente en el mundo digital y jurídico, principalmente por su capacidad de crear un ecosistema ideal para la ejecución de contratos inteligentes. Así como su utilidad para desarrollar procedimientos arbitrales accesibles, sobre todo en conflictos de pequeña cuantía. En el presente artículo se brinda un panorama general del blockchain que, aunque aún permanece en etapa embrionaria, ha demostrado avances significativos con relación a los contratos inteligentes y mecanismos de resolución de conflictos. Asimismo, se exponen las cualidades particulares de esta tecnología que, aplicada en el arbitraje, representan múltiples beneficios a diferencia de un arbitraje convencional.
IDENTIFICATION AND ANALYSIS OF CAUSES FOR SOFTWARE BUG REJECTION WITH THEIR IMPACT OVER TESTING EFFICIENCY

A significant percentage of software bugs reported during test cycles falls in a category of Invalid bug reports also known as rejected bugs. This research presents the actual percentage of bugs rejection based on data collected from bug tracking system. This paper provides a list of reasons behind bug rejection, their relation with severity level and possible threats that can affect software testing efficiency with reference to the life of a rejected bug.
Efecto de la orientación de las tareas de entrenamiento en fútbol femenino

El objetivo de este estudio ha sido analizar si la modificación de las tareas de entrenamiento, en concreto la orientación del espacio, tiene consecuencias en los diferentes parámetros que identifican la carga de trabajo en el fútbol femenino. En el estudio participaron 18 jugadoras de fútbol femenino (M = 21.89; DT = 6.20), que realizaron dos sesiones con cuatro tareas cada una. Las tareas estaban contrabalanceadas para cada sesión para evitar el efecto del orden de las mismas. Se utilizaron GPS Polar Team Pro para medir la carga física y cuestionarios para la carga mental. Para comparar los resultados de cada sesión se llevó a cabo una prueba T de medidas relacionadas. Los resultados muestran que la carga física fue mayor en las tareas donde no hubo orientación, al igual que la carga mental. Por tanto, el espacio en el que se desarrollan las tareas de entrenamiento resulta determinante en la carga mental percibida en fútbol femenino.
Knowledge and Awareness of Buccal Mucosa Cancer amongst Physiotherapist

Background- Buccal mucosa cancer is among the top three types of cancers in India. It is a malignant neoplasia which arises on the lip or buccal cavity. Despite the general global trend of a slight decrease in the incidence of buccal mucosal cancer, tongue cancer incidence is increasing rapidly. buccal mucosal cancer is two to three times more prevalent in men than women in most groups. The main risk factors of head and neck cancer globally are smoking and alcohol, as well as DNA oncogenic viruses and habits, such as betel nut. Brief practices observed by general public could be impacted in a positive way, when adequate knowledge is provided by health care professional. Hence, it is necessary to know if they have the knowledge and awareness about the preventable buccal mucosal cancer amongst physiotherapists. Purpose- To evaluate the knowledge and awareness of buccal mucosal cancer amongst physiotherapists. Method- A cross sectional study was conducted on physiotherapists. Data was collected using questionnaire which was pre-designed and self-made. The questionnaire included specific questions to test participants knowledge and awareness related to buccal mucosal cancer. Data analysis was done by SPSS Version 20.0. Results- Data from 130 participants were included for final analysis. The mean age of participants was 24.5 years. Conclusion- The study shows fair knowledge and awareness of buccal mucosal cancer amongst physiotherapists. Only 60 -70% participants appeared to be having fair level of knowledge (in terms of prevalence, aetiology, signs & symptoms, treatment) Key words: Knowledge, Awareness, buccal mucosal cancer, Prevention Physiotherapist.
Implementación de métodos computacionales para estimar las amplitudes angulares de los miembros inferiores durante el squat

En biomecánica, los sistemas de captura de movimiento basados en video y en marcadores son el método más utilizado para la estimación de parámetros cinemáticos. A nivel técnico, los errores experimentales en la captura de datos suelen estar relacionados con el ocultamiento de los marcadores durante la captura del movimiento. Este fenómeno genera una pérdida de datos que puede afectar el análisis de los resultados. La falta de datos se resuelve aumentando el número de cámaras o utilizando dispositivos adicionales como sensores inerciales. Estas adiciones incrementan el costo experimental de este método. Actualmente, para resolver este tipo de problemas de forma menos costosa, se podrían utilizar nuevos métodos computacionales. Este estudio tiene como objetivo implementar dos métodos computacionales basados en red neuronal artificial (RNA) y regresión de vectores de soporte (RVS) para estimar la amplitud del ángulo de las extremidades durante la ejecución de un movimiento a partir de un solo eje (eje Z). Para entrenar y validar los modelos, se utilizaron características del ejercicio de squat. Los resultados obtenidos incluyeron valores de raíces de error cuadrático medio (RMSE) inferiores a 14 (RMSE mínimo de 5.35) y valores de CC cercanos a 0.98. Los valores estimados son muy cercanos a los ángulos de amplitud experimentales, los análisis estadísticos muestran que no hay diferencias significativas entre las distribuciones y las medias de los valores de amplitud estimados y los valores reales (valor p>0.05). Los resultados demuestran que estos métodos podrían ayudar a los investigadores en biomecánica a realizar análisis precisos, reduciendo el número de cámaras necesarias, reduciendo la incertidumbre y evitando problemas por perdida de datos.
Path tracking of autonomous vehicle with consideration of vehicle stability in sideslip angle phase plane

In current research of autonomous vehicle path tracking, most contributions focus on tracking accuracy during complex driving condition. However, the vehicle might fall into unstable dangerous condition when the road curvature is big or with high speed. A path tracking control framework is proposed in this paper, which considers path tracking accuracy and vehicle stability. In general, the control framework consists of three main components: vehicle stability judging controller, path tracking controller, and torque distributor. Firstly, the stability of the current vehicle can be evaluated by the stability judgment controller according to the phase plane of the sideslip angle. Then, the proportion of vehicle stability in the control objective is adjusted according to the current vehicle stability. To improve the path tracking accuracy, the path tracking is composed of a combined controller using MPC algorithm, which controls the front wheel angle and direct yaw moment at the same time. After that, the torque distributor is developed to distribute the desired yaw moment into four executive wheels, which synthesizes the results of power performance distribution and stability distribution. Finally, the effectiveness of the proposed control framework is verified by the Matlab-CarSim co-simulation experiment and the hardware-in-the-loop experiment based on LabVIEW-RT. The results show that the proposed controller has better tracking accuracy and stability than the general MPC controller.
Functional Connectivity Methods and Their Applications in fMRI Data

The availability of powerful non-invasive neuroimaging techniques has given rise to various studies that aim to map the human brain. These studies focus on not only finding brain activation signatures but also on understanding the overall organization of functional communication in the brain network. Based on the principle that distinct brain regions are functionally connected and continuously share information with each other, various approaches to finding these functional networks have been proposed in the literature. In this paper, we present an overview of the most common methods to estimate and characterize functional connectivity in fMRI data. We illustrate these methodologies with resting-state functional MRI data from the Human Connectome Project, providing details of their implementation and insights on the interpretations of the results. We aim to guide researchers that are new to the field of neuroimaging by providing the necessary tools to estimate and characterize brain circuitry.
Prevalence of microsatellite instable and Epstein-Barr Virus-driven gastroesophageal cancer in a large Belgian cohort.

Introduction Patients with gastroesophageal adenocarcinoma (GEC) with microsatellite instability-high (MSI-H) or Epstein Barr Virus positivity (EBV+) might be good candidates for immunotherapy. Incidences of about 10% have been reported for both features, but are dependent on geographical region and disease stage. Aim The aim is to study the prevalence of MSI-H and EBV+ in a Belgian single center cohort of patients with GEC. Methods We retrospectively assessed the files of all patients with a newly diagnosed GEC between August, 1st 2018 and February, 29th 2020 at the University Hospitals Leuven, Belgium. Microsatellite instability (MSI) status was determined using immunohistochemistry (IHC) and polymerase chain reaction (PCR). EBV+ was assessed using in situ hybridization (ISH). A case report is provided to illustrate the importance of testing for MSI in GEC. Results 247 gastroesophageal adenocarcinomas were included in this analysis. 62 (56% stage IV) of those were tested for EBV, but only 1 turned out to be EBV positive (1.6%). 116 patients (44.0% stage IV) were tested for MSI, of which 11 were MSI-H (9.5%). Half of the MSI-H tumors identified were at the gastroesophageal junction (GEJ). A patient with MSI-H metastatic GEC obtained a complete response with nivolumab, which persisted after discontinuation of treatment. Conclusion While we confirm that about 10% of GECs are MSI-H, the incidence of EBV+ in our cohort (1.6%) is clearly lower than expected. Given the important prognostic and predictive implications, every gastroesophageal cancer should be tested for MSI.
Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease

Aspirin-exacerbated respiratory disease (AERD) is characterized by overproduction of the pro-inflammatory eicosanoids. Although immunoglobulin E-mediated sensitization to aeroallergens is common among AERD patients, it does not belong to the defining disease characteristics. In this study of 133 AERD patients, we sought to find a relationship between sensitization to aeroallergens and local (leukotriene E4, prostaglandin E2 and prostaglandin D2) and/or systemic (leukotriene E4) production of arachidonic acid metabolites. Interestingly, a negative association between pro-inflammatory eicosanoid levels in induced sputum supernatant or urine and sensitization to aeroallergens was observed. This inverse relationship might suggest the presence of a protective effect of atopic sensitization to aeroallergens against stronger local airway inflammation and higher systemic AERD-related inflammatory activity.
48-Pulse Voltage-Source Converter Based on Three-Level Neutral Point Clamp Converters for Solar Photovoltaic Plant

The demand for high-power converters for use in large-scale solar photovoltaic (PV) plants increases as the plant size continues to grow. The multipulse voltage-source converter (VSC) configurations are the viable option for high-power solar PV converter applications because they improve conversion efficiency due to low switching losses and allow direct integration with a medium-voltage (MV) grid. In this article, a 48-pulse VSC based on the fundamental frequency switching (FFS) three-level neutral point clamp (NPC) converter with a start–delta transformer configuration is used for large-scale solar PV plant application. It is also used as a PV-static synchronous compensator (STATCOM) to provide the required reactive power support to the grid to regulate the voltage. The solar PV plant configuration for a 100-MW capacity is modeled in MATLAB and implemented in the real-time OPAL-RT platform to verify its design and controls. The harmonics, static, and dynamic performances are demonstrated in detail.
Private Training Providers in Australia: Their Characteristics and Training Activities

This study by Roger Harris, Michele Simons, Carmel McCarthy examines the nature of the training activity of private registered training organisations (RTOs) offered to Australian students in 2003, based on data from a national sample of 330 RTOs. The study also provides estimates of the private sector's overall contribution to the total vocational education and training (VET) effort in Australia for that year. Private providers are diverse and cover a wide variety of types. Generally they are small organisations offering a wide range of programs; both accredited and non-accredited. While there are some issues relating to data quality, it is clear they make a substantial contribution to the overall Australian VET effort. It is estimated that, in 2003, private RTOs had about 2.2 million students, which compares with 1.7 million students in the publicly funded sector in that year. However, comparisons with the public VET sector are problematic because there are no estimates available of the training hours delivered by private RTOs.
Gurson–Tvergaard–Needleman model guided fracture‐resistant structural designs under finite deformations

A finite strain shear modified Gurson–Tvergaard–Needleman (GTN) model based on multiplicative elastoplasticity, together with its implementation details, is presented. This GTN model which can simulate the loss of load‐carrying capacity of porous metals through nucleation, growth, shearing, and coalescence of voids is incorporated in an optimization framework for designing structures with optimal plastic energy dissipation capacity while satisfying prescribed constraints on material usage and damage. An adjoint method‐based analytical path‐dependent sensitivity analysis is presented that can be used with gradient‐based optimization algorithms. Using the proposed topology optimization formulations, the optimized designs exhibit well‐constrained fracture at the design displacements. Ultimate performance analyses of the optimized designs demonstrate that the fracture‐resistant designs can have higher ductility, ultimate strength as well as improved energy dissipation, as compared to the designs guided by von Mises plasticity where no fracture mechanisms are modeled. Moreover, due to finite deformations, a fracture can initiate at multiple locations and critical fracture locations can change during the loading process. In addition, different failure modes are revealed from different optimized designs under large deformations.
Import, Export and Trade Intermediaries: What Matters the Most?

This paper undertakes a multi-country study to investigate heterogeneity in productivity levels across firms choosing to trade either directly or indirectly through intermediaries, both in the export and import markets. To this end, we implement a stochastic dominance criterion to compare the entire distribution of Total Factor Productivity (TFP) of traders, and we use a generalized ordered logit model to investigate the extent to which a shift in TFP produces a reallocation of firms among different categories of traders. Compared to previous research, our novel findings suggest a productivity sorting of firms which mostly depends on the mode of trade rather than the side. From a policy perspective, our work implies the need to create the conditions for endowing local firms with the necessary knowledge and capabilities to overcome the productivity threshold levels to enter and benefit from direct international trade.