Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Cooking Method on the Nutritional Quality of Organic and Conventional Brazilian Vegetables: A Study on Sodium, Potassium, and Carotenoids

Vegetable consumption is associated with increased health benefits, and vegetables are consumed both in cooked form and raw form in salads. All cooking techniques cause changes in a vegetable’s the nutrient content. Consumers are increasingly health-conscious and have less time to prepare meals, and they do not know which cooking times and cooking methods are best suited to preserve the nutrients. This study aimed to determine the best method of cooking vegetables to maintain minerals (potassium and sodium) and carotenoids. The studied vegetables were broccoli (Brassica oleracea, var. Italica), carrots (Daucus carota), and zucchini (Cucurbita moschata). The cooking methods were: boiling, steaming, combined oven, microwave steaming, and microwave cooking. Samples of organic and conventionally grown vegetables were prepared in triplicate. Samples were analyzed to determine the availability of target minerals and carotenoids in the raw food and in each recommended cooking situation according to technical standards. Only the carrot showed a higher concentration in organic cultivation for carotenoids in raw vegetables, with both zucchini and broccoli having higher concentrations when grown by conventional cultivation. The zucchini from organic cultivation presented a reduction of potassium and sodium, almost consistently, in all cooking techniques. Regarding the conventionally cultivated zucchini, potassium remained stable in boiling. Broccoli from organic and conventional cultivation showed similar potassium levels for boiling and traditional steam cooking. Organic carrots showed easier sodium extraction compared with conventional cultivation. Heat treatment, in general, improves the accessibility of carotenoids.
Neurosurgical Management and Outcome Parameters in 237 Patients with Spondylodiscitis

Surgical treatment of spondylodiscitis allows for rapid mobilization and shortens hospital stays, which makes surgical treatment the first-line therapy. We aim to describe our experiences with operative treatment on spondylodiscitis and to determine the parameters that are important in the prediction of outcomes. A retrospective review identified 237 patients who were operatively treated for spondylodiscitis in our institution between January 2010 and December 2018. Clinical data were collected through review of electronic records and relevant imaging. In all cases, contrast-enhancing MRI from the infected region of the spine was obtained. Leukocyte count and C-reactive protein concentrations (CRP) were determined in all the patients. We included 237 patients in the study, 87 female (36.7%) and 150 male (63.3%), with a mean age of 71.4 years. Mean follow-up was 31.6 months. Forty-five patients had spondylodiscitis of the cervical, 73 of the thoracic, and 119 of the lumbosacral spine. All the patients with spondylodiscitis of the cervical spine received instrumentation. In thoracic and lumbar spine decompression, surgery without instrumentation was performed in 26 patients as immediate surgery and in a further 28 patients in the early stages following admission, while 138 patients received instrumentation. Eighty-nine patients (37.6%) had concomitant infections. Infection healing occurred in 89% of patients. Favorable outcomes were noted in patients without concomitant infections, with a normalized CRP value and in patients who received antibiotic therapy for more than six weeks (p < 0.05). Unfavorable outcomes were noted in patients with high CRP, postoperative spondylodiscitis, and recurrent spondylodiscitis (p < 0.05). Application of antibiotic therapy for more than six weeks and normalized CRP showed a correlation with favorable outcomes, whereas concomitant infections showed a correlation with unfavorable outcomes. A detailed screening for concomitant infectious diseases is recommended.
Sugar- and Artificially Sweetened Beverages Consumption Linked to Type 2 Diabetes, Cardiovascular Diseases, and All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies

Although studies have examined the association between habitual consumption of sugar- (SSBs) and artificially sweetened beverages (ASBs) and health outcomes, the results are inconclusive. Here, we conducted a dose-response meta-analysis of prospective cohort studies in order to summarize the relationship between SSBs and ASBs consumption and risk of type 2 diabetes (T2D), cardiovascular diseases (CVDs), and all-cause mortality. All relevant articles were systematically searched in PubMed, Embase, and Ovid databases until 20 June 2020. Thirty-four studies met the inclusion criteria and were eligible for analysis. Summary relative risks (RRs) and 95% confidence intervals (95% CI) were estimated using random effects or fixed-effects model for highest versus lowest intake categories, as well as for linear and non-linear relationships. With each additional SSB and ASB serving per day, the risk increased by 27% (RR: 1.27, 95%CI: 1.15–1.41, I2 = 80.8%) and 13% (95%CI: 1.03–1.25, I2 = 78.7%) for T2D, 9% (RR: 1.09, 95%CI: 1.07–1.12, I2 = 42.7%) and 8% (RR: 1.08, 95%CI: 1.04–1.11, I2 = 45.5%) for CVDs, and 10% (RR: 1.10, 95%CI: 0.97–1.26, I2 = 86.3%) and 7% (RR: 1.07, 95%CI: 0.91–1.25, I2 = 76.9%) for all-cause mortality. Linear relationships were found for SSBs with T2D and CVDs. Non-linear relationships were found for ASBs with T2D, CVDs, and all-cause mortality and for SSBs with all-cause mortality. The findings from the current meta-analysis indicate that increased consumption of SSBs and ASBs is associated with the risk of T2D, CVDs, and all-cause mortality.
Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities

The synthesis of new compounds with antimicrobial and antiviral properties is a central objective today in the context of the COVID-19 pandemic. Benzimidazole and pyrazole compounds have remarkable biological properties, such as antimicrobial, antiviral, antitumor, analgesic, anti-inflammatory, anti-Alzheimer’s, antiulcer, antidiabetic. Moreover, recent literature mentions the syntheses and antimicrobial properties of some benzimidazole–pyrazole hybrids, as well as other biological properties thereof. In this review, we aim to review the methods of synthesis of these hybrids, the antimicrobial activities of the compounds, their correlation with various groups present on the molecule, as well as their pharmaceutical properties.
Relationship between 25 Hydroxyvitamin D, Overweight/Obesity Status, Pro-Inflammatory and Oxidative Stress Markers in Patients with Type 2 Diabetes: A Simplified Empirical Path Model

Vitamin D deficiency is highly prevalent in patients with overweight/obesity and type 2 diabetes (T2DM). Herein, we investigated the relationship between vitamin D status and overweight/obesity status, insulin resistance (IR), systemic inflammation as well as oxidative stress (OS). Anthropometric and laboratory assessments of 25-hydroxyvitamin D (25(OH)D) and glycemic, pro-inflammatory and OS biomarkers were performed in a sample of 47 patients with T2DM who were divided into categories based on overweight and degree of obesity. The main findings were: the overweight/obesity status correlated negatively with the degree of serum 25(OH)D deficiency (ρ = −0.27) with a trend towards statistical significance (p = 0.069); the homeostasis model assessment of insulin resistance (HOMA-IR) was significantly different (p = 0.024) in patients with 25(OH)D deficiency, as was total oxidant status (TOS) and oxidative stress index (OSI) in patients with severe serum 25(OH)D deficiency as compared to those with 25(OH)D over 20 ng/mL (TOS: p = 0.007, OSI: p = 0.008); and 25(OH)D had a negative indirect effect on TOS by body mass index (BMI), but BMI was not a significant mediator of the studied relationship. In a setting of overweight and increasing degree of obesity, patients with T2DM did not display decreasing values of 25(OH)D. Subjects with the lowest values of 25(OH)D presented the highest values of BMI. Patients with 25(OH)D deficiency were more insulin resistant and showed increased OS but no elevated systemic inflammation. The negative effect of 25(OH)D on TOS did not seem to involve BMI as a mediator.
Creating a Pediatric Prehospital Destination Decision Tool Using a Modified Delphi Method

Decisions for patient transport by emergency medical services (EMS) are individualized; while established guidelines help direct adult patients to specialty hospitals, no such pediatric equivalents are in wide use. When children are transported to a hospital that cannot provide definitive care, care is delayed and may cause adverse events. Therefore, we created a novel evidence-based decision tool to support EMS destination choice. A multidisciplinary expert panel (EP) of stakeholders reviewed published literature. Four facility capability levels for pediatric care were defined. Using a modified Delphi method, the EP matched specific conditions to a facility pediatric-capability level in a draft tool. The literature review and EP recommendations identified seventeen pediatric medical conditions at risk for secondary transport. In the first voting round, two were rejected, nine met consensus for a specific facility capability level, and six did not reach consensus on the destination facility level. A second round reached consensus on a facility level for the six conditions as well as revision of one previously rejected condition. In the third round, the panel selected a visual display format. Finally, the panel unanimously approved the PDTree. Using a modified Delphi technique, we developed the PDTree EMS destination decision tool by incorporating existing evidence and the expertise of a multidisciplinary panel.
Influence of Temperature and Photoperiod on the Fecundity of Habrobracon hebetor Say (Hymenoptera: Braconidae) and on the Paralysis of Host Larvae, Plodia interpunctella (Hübner) (Lepidoptera: Pyralidae)

Simple Summary This study illustrated the role of optimum temperatures of 25 and 30° in maximizing oviposition by the female H. hebetor. The optimum temperatures for paralysis of P. interpunctella larvae by H. hebetor were shown to be 28 and 30 °C at short exposure periods. However, at long exposure periods, the paralysis rates did not differ significantly. Photoperiod had no impact on oviposition or paralysis of P. interpunctella by the wasp. Abstract Studies were carried out in the laboratory to understand the optimum environmental conditions at which the ectoparasitoid, Habrobracon hebetor Say (Hymenoptera: Braconidae), can paralyze and lay eggs when reared on the larvae of the stored product pest, Plodia interpunctella Hübner (Lepidoptera: Pyralidae). At the four temperatures investigated (20, 25, 30, and 35 °C), optimum temperatures for oviposition were found to be 25 and 30 °C, while 35 °C was the least favorable temperature. No significant differences were found between the percentages of diapausing and non-diapausing larvae paralyzed by the wasp at the temperatures of 20, 25, 30, 35 °C within 5 days. However, in another experiment that investigated the effect of photoperiods at different temperatures that included 15, 19 and 28 °C, the number of paralyzed larvae was highly reduced at low temperatures (15 °C) but photoperiods had no significant impact on the number of host larvae paralyzed. In addition, observations at short time intervals also showed that lower temperatures slowed down host larvae paralysis. The results suggest that H. hebetor can paralyze host larvae of P. interpunctella more efficiently and deposit more eggs at temperatures within the range of 20–30 °C.
SHORTER HOURS AND PRODUCTIVITY: EVIDENCE FROM COAL MINING

At the turn of the twentieth century, advocates for shorter working hours often claimed that workers were so fatigued by the end of the workday, that shortening daily hours from ten to eight would have little effect on output. This study examines the record for coal mining, analyzing both state-level and mine-level panel data during the transition to the eighthour day. The hypothesis of zero effect is easily rejected. In fact, output declined almost proportionately with hours, but advancing technology made up for the lost output fairly quickly. There is some evidence that employment increased when the eight-hour day was adopted, as unionists hoped, but the effect is not precisely measured.
DMSO_A_291638 601..616

*These authors contributed equally to this work Objective: This study was aimed to investigate the potential active components, targets and mechanisms of silkworm excrement (SE) in the treatment of type 2 diabetes mellitus (T2D) based on THE network pharmacology combined with experimental verification. Methods: Firstly, the inhibitory effects of SE on α-glucosidase were measured in vitro. Then, the potential active components and potential targets of SE and the targets of T2D were collected and screened using bioinformatics databases. Then, the R language, Cytoscape, Perl software were used to screen and visualize important components, targets, biological processes and signaling pathways. Finally, the predicted results by network pharmacology were verified via glucose absorption assay, oil red O staining assay and Western blot assay. Results: Our results showed SE effectively inhibited the activities of α-glucosidase. The results of network pharmacology suggested there were 33 potential active ingredients and 42 potential targets in SE. The molecular pathways of SE against T2D were further predicted, including response to insulin-like growth factor receptor binding, protein serine/threonine kinase activity, and MAP kinase activity. KEGG pathway analyses predicted potential targets were involved in multiple signaling pathways, such as insulin signaling pathway, insulin resistance pathway and AMPK signaling pathway. In IR HepG2 cells, SE treatments increased glucose consumption and decreased lipogenesis. The insulin resistance (IR)related AMPK/PI3K/AKT signaling was further studied and the results showed SE could significantly up-regulate the phosphorylation levels of AMPK, PI3K, and Akt proteins in IRHepG2 cells. Conclusion: Our results suggested AMPK/PI3K/Akt signaling is an important way for the anti-type 2 diabetic activity of silkworm excrement by using an integrated approach based on network pharmacology combined with experimental verification.
ENVIRONMENTAL REGUL ATION , ENTREPRENEURSHIP AND ECONOMIC GROW TH : AN EMPIRICAL STUDY BASED ON THRESHOLD EFFEC T TEST IN CHINA

1 Based on panel data from 2000 to 2017 on 30 provinces in China, we analyse the threshold effect of environmental regulation on the quality improvement of economic growth in Eastern, Central, and Western China using a threshold regression model with entrepreneurship as the threshold variable. The conclusions are as follows: (1) With a low entrepreneurship index, environmental regulation inhibits the quality of regional economic growth. When the entrepreneurship index is at a middle level, the effect changes from an original adverse impact to a favourable impact, which is very significant in Eastern and Western China, but not significant in Central China. When entrepreneurship is highly active, environmental regulation is beneficial to economic growth quality in all regions, and environmental regulation can bring into play the function of “reversed mechanism” to promote economic growth quality. (2) The differences in entrepreneurship level in the three regions lead to regional heterogeneity of the threshold effect between environmental regulation and economic growth quality. Eastern China realizes a double dividend of environmental improvement and economic growth. The entrepreneurial activity in the Central and Western regions is a little far away from their threshold values, at which environmental regulation can produce a significant incentive effect. In conclusion, we put forward three suggestions to improve the entrepreneurial activity and fully realize the double dividend of environmental improvement and economic growth.
Features of the course of pregnancy and the outcomes of childbirth in women of different ages.

This article presents the features of pregnancy in adolescence and old age associated with a high risk of adverse outcomes both during pregnancy and childbirth, and in the later period. The purpose of our study was to identify the features of pregnancy and childbirth, the postpartum period in young and elderly mothers. Materials and Methods: The history of pregnancy, childbirth and individual charts of newborns (n=330) were retrospectively analyzed, of which group I (n=150) young pregnant women aged 13-18 years, group II (n=80) pregnant women of favorable reproductive age (20-25 years) and group III (n=100) women of late reproductive period (40 years and older). Results: It was found that young primiparous women are somatically healthier, but sexually transmitted infections are significantly more common in the group of underage pregnant women (pIIII= 0.043) than in the group of late reproductive period. Pregnancy in adolescents often occurs against the background of anemia, placental insufficiency, moderate preeclampsia; childbirth is complicated by a large percentage of injuries. In the group of women of late reproductive age, diseases of the cardiovascular system, mainly arterial hypertension, obesity, and liver diseases predominate. Conclusion: Pregnancy in adolescent girls, as well as in age-related primiparous women, is a serious medical and social problem. Pregnant women in these groups are at high risk for miscarriage and require an individual approach to the management of pregnancy and childbirth.
In-Operando Characterization of P-I-N Perovskite Solar Cells Under Reverse Bias

A solar module is often exposed to a variety of intensity and uniformity illumination conditions throughout a day. In the field, objects or dirt can block light from hitting the module creating a partial shading event. When a partial shading event occurs the module power point tracking system will typically push the shaded cells into reverse bias in order to avoid the current loss from the other series connected illuminated cells. When perovskite solar cells are operated in reverse bias, electrochemical reactions can occur, leading to both reversible and irreversible performance losses. Excess holes generated by reverse bias cause and push the oxidation reaction of halide ions from the lattice to neutral halogen interstitial. Small interstitial halogen atoms can diffuse across the device and potentially move from the perovskite layer and into the transport layers, shifting the fermi levels in the devices. In this investigation we utilize cross-sectional kelvin probe atomic force microscopy to map the band energetics of perovskite solar cells during reverse bias. We observe a 150 meV decrease in the work function of the C60. This leads to a decrease of 150 mV and 4 mA/cm2 in Voc and in Jsc respectively. Finally, we discuss methods to prevent this irreversible degradation after a perovskite device is held under reverse bias.
Linear Expressions of Drawbar Pull and Driving Torque for Grouser-Wheeled Planetary Rovers Without Terrain Mechanical Parameters

Drawbar pull and driving torque are usually applied to characterize the mobility and energy consumption, respectively, of wheeled planetary rovers (WPRs) traversing sandy terrain. Owing to the complexity of the grouser-terrain interaction, neither can be modeled as a closed-form analytical expression of the terrain mechanical parameters. Complexity limits their online applications. Moreover, it is difficult to estimate the terrain mechanical parameters. To solve these issues, based on equivalent wheel sinkage, both the drawbar pull and driving torque can be modeled as a linear function of physically measurable quantities in the absence of terrain mechanical parameters, which is demonstrated using single-wheel experiments conducted with four types of wheels and two sand types. The influence of a sophisticated grouser-terrain interaction on wheel sinkage can be explicitly determined using the linear driving torque model. Furthermore, the validated linear drawbar pull equation is used to estimate the slope-climbing capability of a four-wheeled planetary rover prototype by computing the slope-climbing coefficient, and the relative error can be limited to 10%. In addition, the wheel driving torque of the rover prototype can also be accurately predicted.
The Potential of Toll-Like Receptors to Modulate Avian Immune System: Exploring the Effects of Genetic Variants and Phytonutrients

Toll-like receptors (TLRs) are pathogen recognition receptors, and primitive sources of innate immune response that also play key roles in the defense mechanism against infectious diseases. About 10 different TLRs have been discovered in chicken that recognize ligands and participate in TLR signaling pathways. Research findings related to TLRs revealed new approaches to understand the fundamental mechanisms of the immune system, patterns of resistance against diseases, and the role of TLR-specific pathways in nutrient metabolism in chicken. In particular, the uses of specific feed ingredients encourage molecular biologists to exploit the relationship between nutrients (including different phytochemicals) and TLRs to modulate immunity in chicken. Phytonutrients and prebiotics are noteworthy dietary components to promote immunity and the production of disease-resistant chicken. Supplementations of yeast-derived products have also been extensively studied to enhance innate immunity during the last decade. Such interventions pave the way to explore nutrigenomic approaches for healthy and profitable chicken production. Additionally, single-nucleotide polymorphisms in TLRs have shown potential association with few disease outbreaks in chickens. This review aimed to provide insights into the key roles of TLRs in the immune response and discuss the potential applications of these TLRs for genomic and nutritional interventions to improve health, and resistance against different fatal diseases in chicken.
Comparison of 1.9 eV InGaP front- and rear-junction solar cells grown on Si

In this work, we compare the performance of front-junction (FJ) and rear-heterojunction (RHJ) 1.9 eV InGaP solar cells grown on Si by molecular beam epitaxy (MBE). The RHJs had greater Voc than the FJs on Si, even with ~10 × higher threading dislocation density (TDD), indicating superior dislocation tolerance of the n-type absorber of the RHJ compared to the p-type absorber of the FJ. However, poor internal quantum efficiency (IQE) of the RHJ on Si due to insufficient diffusion length also limited cell efficiency. Based on modeling, a thinner RHJ absorber will greatly boost the short circuit current density (Jsc), enabling high-performance InGaP RHJs for epitaxial III-V/Si solar cells.