Miracle-dz/UniFAR-FTUs huggingface dataset:
Circulation analysis of design alternatives for elderly housing unit allocation using building information modelling-enabled indoor walkability index

In retrofit-purposed projects such as building renovations, the early decision-support mechanism to determine an optimistic circulation plan and spatial allocation is strongly required for architects, owners and residents. In this paper, we introduce such a case study based on the building information modelling-enabled approach that has been explored using an actual project at Yeongwol, South Korea for resolving diverse residential types, including elderly housing units. The objective of this paper is to demonstrate an actual analysis of building remodelling design alternatives regarding indoor circulation and spatial allocation problems, especially considering elderly housing units. Another significant feature of this paper is a quantitative and explicit approach to the indoor walkability index using building information modelling. After acquiring indoor circulation data, such as metric distances between rooms, number of turns, spatial depth, vertical access, or any other BIM-enabled data, an appropriate and teleological weighting function was applied to determine the indoor walkability index. The usefulness of the approach was demonstrated in this paper, based on a Yeongwol project. building information modelling-enabled data provided prompt and reliable quantitative analysis results as soon as various design alternatives appear within the given timeframe to resolve circulation and spatial allocation problems for remodelling homes for the elderly.
Erfahrungen zur Nutzung von Mixed und Virtual Reality im Lehralltag an der HTW Dresden

1 Einführung und Motivation Der Einsatz von immersiven Systemen, also Virtual Reality (VR), Augmented Reality (AR) und Mixed Reality (MR) Systemen in der Lehre ist naheliegend. Eigene interaktive Erfahrung einer Tätigkeit ist immer einer reinen rezeptiven Beobachtung bzw. verbalen Erläuterung vorzuziehen. Trotzdem ist heutige Lehre selbst in Praktika und Übungen zum sehr großen Teil passiv, die selbständige Umsetzung, etwa das Bedienen einer Anlage oder die eigenständige Synthese einer Chemikalie, können aus Gründen der Zeit, Verfügbarkeit, Sicherheits bedenken und Kostengründen oft nur selten eingesetzt werden. Dem Einsatz o.g. neuer immersiven Technologien stand bisher nicht nur der erhebliche Aufwand zur Erstellung entsprechender Simulationen gegenüber. Vor allem aber auch der Hardwareaufwand bei gleichzeitigem nicht optimalem Grad an Immersivität ließ kaum Möglichkeiten offen. Jeden Studenten einzeln ausreichend Zeit in einer teuren und großen Cave-Umgebung zu ermöglichen, damit dieser virtuell technische Anlagen bedient, ist für größere Studentenzahlen untauglich.
Physiological Control of Chloride Transport in Chara corallina1 II. THE ROLE OF CHLORIDE AS A VACUOLAR OSMOTICUM

The extent to which Cl is replaceable as the major anionic constituent of the vacuole of Chara corallina was investigated. It was found that external Cl is not essential in order for nongrowing cells to increase internal osmotic pressure. After growth of cells in low (9 micromolar) Cl1, the vacuolar Clr concentration is one-half that of cells grown at normal external Clr concentration (850 micromolar). In contrast, both internal osmotic pressure and total concentration of the major cations, K+ and Na+, in the same cells were found to be only slightly sensitive to the external Clr concentration. Thus, it is proposed that, at limiting external Cl concentration, the cell is able to transport or synthesize another anion for vacuolar use rather than utilize a neutral solute. Although the total vacuolar (K+ + Na+) concentration is relatively insensitive to low Cl conditions, a large increase in K+ was recorded. This increase in K+ was offset by a correspondingly large fail in Na+. This is unrelated to any mechanistic dependence of Na+ on Cl- for entry into the cell but may indicate a control system acting on vacuolar sequestration of both Na+ and Cl-. Cells grown in low Cl- display an ability to take up Cl-, at enhanced rates, from the medium. The enhancement of Cl- influx is maintained for several hours after external Cl is raised to a high level and indicates the existence of a control on Cl influx acting in addition to that of cytoplasmic Cl concentration, which has a shorter decay time. The results are discussed in relation to similar work on higher plants.
CIA_A_255640 1317..1323

1Department of Endoscopy, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People’s Republic of China; 2Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People’s Republic of China; 3CardioCerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong, People’s Republic of China; 4Renal Division, Department of Medicine, Peking University International Hospital, Beijing, China; 5National Institute of Health Data Science at Peking University, Beijing, People’s Republic of China; 6Peking University, Center for Data Science in Health and Medicine, Beijing, People’s Republic of China
Pengaruh Kepemimpinan Transformasional, Partisipasi, Komunikasi dan Motivasi Kerja Terhadap Komitmen untuk Perubahan (Studi Pada Dosen dan Pegawai Akademi Maritim Sapta Samudra Padang)

Tujuan dari penelitian ini adalah untuk menentukan faktor-faktor yang mempengaruhi komitmen untuk perubahan pada dosen dan pegawai di Akademi Maritim Sapta Samudra Padang. Komitmen untuk perubahan adalah faktor kunci keberhasilan di dalam organisasi dari perubahan organisasi. Oleh karena itu upaya untuk menemukan faktor-faktor yang mempengaruhinya menjadi hal yang penting. Penelitian ini menggunakan 35 responden. Analisis regresi linier berganda dengan menggunakan SPSS versi 17. Penelitian ini menunjukkan bahwa ada tiga variabel yang signifikan dan positif berpengaruh terhadap komitmen untuk perubahan. Sedangkan variabel motivasi kerja tidak terdapat pengaruh yang signifikan dengan komitmen untuk berubah. Secara praktis, hasil penelitian ini dapat digunakan oleh pimpinan Akademi Maritim Sapta Samudra Padang untuk menjalankan komitmen untuk berubah dengan meningkatkan kepemimpinan transformasional, partisipasi, dan komunikasi. Sementara secara teoritis penelitian ini memberi kontribusi prilaku terencana.
Structure in 6 D and 4 D N = 1 supergravity theories from F-theory

We explore some aspects of 4D supergravity theories and F-theory vacua that are parallel to structures in the space of 6D theories. The spectrum and topological terms in 4D supergravity theories correspond to topological data of F-theory geometry, just as in six dimensions. In particular, topological axion-curvature squared couplings appear in 4D theories; these couplings are characterized by vectors in the dual to the lattice of axion shift symmetries associated with string charges. These terms are analogous to the GreenSchwarz terms of 6D supergravity theories, though in 4D the terms are not generally linked with anomalies. We outline the correspondence between F-theory topology and data of the corresponding 4D supergravity theories. The correspondence of geometry with structure in the low-energy action illuminates topological aspects of heterotic-F-theory duality in 4D as well as in 6D. The existence of an F-theory realization also places geometrical constraints on the 4D supergravity theory in the large-volume limit.
Long-Term Survival in Patients With Papillary Thyroid Cancer Who Did Not Undergo Prophylactic Central Lymph Node Dissection: A SEER-Based Study

Background The role of prophylactic central lymph node dissection (pCLND) for papillary thyroid cancer (PTC) remains contentious, and the impact of pCLND on long-term patient outcomes is unclear. Methods A retrospective analysis of data from the Surveillance, Epidemiology, and End Results (SEER) database was performed. Patients diagnosed with PTC who did not undergo pCLND between 2004 and 2015 were included in this study, and patients with pN0 PTC who underwent CLND were included as the control group. The researchers calculated the subdistribution hazard ratio (SHR) using the Fine-Gray model and the hazard ratio (HR) using the Cox proportional hazards regression to compare Thyroid cancer-specific survival (TCSS) and overall survival (OS) of the different groups. Results A total of 38,205 T1-2cN0 PTC patients without pCLND were eligible for the study entry, and 24,157 patients with T1-2pN0 PTC patients who had received CLND were included as the control group. The actuarial 10-year TCSS and OS rates of patients without pCLND were 99.53% and 92.77%, respectively. Patients without pCLND had similar TCSS compared with the control group after adjusting for age, sex, race, tumor stage, multifocality, thyroid surgery, and radiation (SHR = 1.35, 95% CI: 0.95 - 1.93). However, patients without pCLND had a significantly poorer OS than the control group (HR = 1.38, 95% CI: 1.26 - 1.51). Conclusions Patients without pCLND had similar TCSS compared with the control group after adjusting for confounders but had significantly poorer OS. Whether the OS disparities were attributed to pCLND or other factors still needs further study.
When to suspect dementia

With global dementia cases approaching 50 000 000, the importance of early and accurate diagnosis is crucial. Primary care clinicians are often the initial point of contact for people, their family and caregivers when dementia is first suspected. People who suspect they, or their loved one, may have dementia often experience significant fear and distress. Timely and accurate diagnosis, with an honest but compassionate discussion of dementia and its prognosis, may alleviate some distress by reducing time to diagnosis. Timely diagnosis may also enable opportunities to use disease-limiting treatments, reduce unnecessary testing and investigations and provides an opportunity to undertake advance care planning.
Knowledge management in consultancy-involved process improvement projects: cases from Chinese SMEs

Abstract Knowledge management (KM) is considered as an effective strategy to improve organizational performance. In its application to small and medium enterprises (SMEs), resource constraints mean that exploitation of knowledge from external sources is often needed. This study explores practical KM issues encountered by Chinese SMEs when working with management consultants to introduce new business improvement practices. A comparative case study is conducted focusing on two consultancy-involved process improvement projects in Chinese manufacturing SMEs. The case results suggest a clear KM strategy is needed at the outset of the project and SME managers and employees need to play a proactive role in the learning and adoption of new knowledge. The research is novel in that it is the first study to explore knowledge management and the notion of liminality within the context of consultancy-involved Chinese SME improvement projects. The paper culminates with two research propositions that require further empirical study.
Estilos de apego y perfil de dificultades en la regulación emocional en una muestra de adolescentes femeninas (16-19 años)

Introducción: El mundo emocional tiene un gran impacto en la vida de las personas. La regulación de las emociones influye significativamente en la calidad de vida y su falta es un factor de riesgo para la aparición de trastornos mentales (ansiedad, depresión, trastorno por estrés post-traumático, autolesiones…). Uno de los elementos que interviene en el desarrollo de la regulación emocional es el estilo de apego. Objetivos: El objetivo principal es estimar la puntuación total y las variables del cuestionario DERS para posteriormente comparar el perfil de las dificultades en la regulación emocional. Material y Métodos: Estudio observacional transversal. El tamaño muestral es 63 sujetos femeninas. Se administraron un cuestionario socio-demográfico, CaMir-R (evaluación del apego en adolescentes), DERS (Escala de Dificultades en la Regulación Emocional) en población adolescentes (16-19 años). Resultados: Hay una diferencia significativa en las dificultades en la regulación emocional en las pacientes según su estilo de apego, principalmente en la variable de Desatención, Descontrol emocional y puntuación total. Se encontró una correlación negativa moderada entre la puntuación de Seguridad del cuestionario Ca-Mir-R y la puntuación total del cuestionario de DERS. Sin embargo solo un 8% de la variabilidad de la puntuación total DERS es explicado por la Seguridad Ca-Mir-R. Conclusiones: Las adolescentes con un estilo de apego inseguro tienen más dificultades para reconocer e identificar sus emociones, y para controlar sus conductas cuando se encuentran bajo un estado emocional intenso. Se justificaría la realización de más estudios, con una especial atención a los distintos estilos de apego inseguros.
Gut Microbiota-Derived Diaminopimelic Acid Promotes the NOD1/RIP2 Signaling Pathway and Plays a Key Role in the Progression of Severe Acute Pancreatitis

Impaired intestinal barrier function and gut microbiota dysbiosis are believed to be related to exacerbation of acute pancreatitis (AP). As a bacterial cell wall peptidoglycan component, diaminopimelic acid (DAP) is a specific ligand of NOD1 that regulates the NOD1/RIP2/NF-kB signaling pathway. Here, we investigated the role of DAP in the crosstalk between the gut microbiota and pancreas during the occurrence of AP. Upregulation of NOD1/RIP2/NF-kB and elevated serum DAP levels were found in severe AP (SAP) model rats. The accumulation of DAP in SAP patients corroborated its ability to serve as an indicator of disease severity. Subsequently, SAP rats were treated with oral administration of the traditional Chinese medicine Qingyi Keli (QYKL) as well as neomycin, which can widely eliminate DAP-containing bacteria. Both QYKL and neomycin intervention ameliorated intestinal and pancreatic damage and systemic inflammation in SAP rats. Through 16S rDNA sequencing, we found that QYKL could rehabilitate the gut microbiota structure and selectively inhibit the overgrowth of enteric bacteria, such as Helicobacter and Lactobacillus, in SAP rats without affecting some protective strains, including Romboutsia and Allobaculum. Interestingly, we demonstrated that the decrease in serum DAP was accompanied by suppression of the NOD1/RIP2/NF-kB signaling pathway in both the intestine and pancreas of the two intervention groups. Taken together, these results suggested that the gut microbiota-DAP-NOD1/RIP2 signaling pathway might play a critical role in the progression of AP and that SAP could be alleviated via intervention in the signaling pathway. Our work provides new potential early warning indicators of SAP and targets for intervention.
Textile Strain Sensor Enhancement by Coating Metal Yarns with Carbon-Filled Silicone

Flexible and stretchable strain sensors are an important development for measuring various movements and forces and are increasingly used in a wide range of smart textiles. For example, strain sensors can be used to measure the movements of arms, legs or individual joints. Thereby, most strain sensors are capable of detecting large movements with a high sensitivity. Very few are able to measure small movements, i.e., strains of less than 5%, with a high sensitivity, which is necessary to carry out important health measurements, such as breathing, bending, heartbeat, and vibrations. This research deals with the development of strain sensors capable of detecting strain of 1% with a high sensitivity. For this purpose, a total of six commercially available metallic yarns were coated with a carbon-containing silicone coating. The process is based on a vertical dip-coating technology with a self-printed 3D coating bath. Afterwards, the finished yarns were interlooped and stretched by 1% while electrical resistance measurements were carried out. It was shown that, although the coating reduced the overall conductivity of the yarns, it also improved their sensitivity to stress. Conclusively, highly sensitive strain sensors, designed specially for small loads, were produced by a simple coating set-up and interlooping structure of the sensory yarns, which could easily be embedded in greater textile structures for wearable electronics.
Tumor pH-Responsive Nanocarriers With Light-Activatable Drug Release for Chemo-Photodynamic Therapy of Breast Cancer

Developing bioresponsive nanocarriers with particular tumor cell targeting and on-demand payload release has remained a great challenge for combined chemo-photodynamic therapy (chemo-PDT). In this study, an intelligent nanocarrier (DATAT-NPCe6) responded to hierarchical endogenous tumor pH, and an exogenous red light was developed through a simple mixed micelle approach. The outside TAT ligand was masked to prevent an unexpected interaction in blood circulation. Following the accumulation of DATAT-NPCe6 in tumor tissues, tumor acidity at pH ∼6.5 recovered its targeting ability via triggering DA moiety degradation. Furthermore, the cascaded chemo-PDT was accomplished through light-stimulated nanocarrier disassembly and doxorubicin (DOX) release. Taking advantage of stability and controllability, this work provides a facile approach to designing bioresponsive nanocarriers and represents a proof-of-concept combinatorial chemo-PDT treatment.
A Concise Review on the Recent Developments in the Internet of Things (IoT)-Based Smart Aquaculture Practices

Abstract A smart aquaculture management system (SAMS) based on the Internet of Things (IoT) has recently gained much attention for fulfilling the growing demand for aquaculture products. The SAMS uses cutting-edge sensing technologies with a modern networking system to continuously monitor water quality, animal health, and feeding behavior to improve the production yield. This review aims to comprehensively summarize and discussed the recent advancements in IoT-based technologies, e.g., sensors nodes, software interfacing, artificial intelligence, cloud computing, and storage, to develop reliable and robust SAMS for small- and large-scale aquaculture production modules. A future perspective section is included at the end of this review to recommend the needed research to be done to scale up the related digital technologies for application in aquaculture farms. The knowledge in this thorough review can be useful for the scientific community for needful advancements and modifications of the IoT technologies and for existing and future aquaculture farmers to adopt modern SAMS for improving the benefit-cost ratios.
Flexible Force-sensing System for Wearable Exoskeleton Using Liquid Pressure Detection

A gait monitoring system based on liquid pressure detection was designed. In this work, based on the study of the plantar pressure distribution, a special cylindrical liquid cavity was located under the foot. For the actual application of an exoskeleton, the human foot is curved by uneven terrain in the alternation of the support and swinging phases. To measure the pressure distribution of the sole over a large measurement range, shoes also need to be flexible. By measuring the fluid pressure, the plantar pressure distribution can be detected during human walking. Assuming sufficient flexibility, this approach could ensure the stable measurement on uneven terrain for the exoskeleton.
Students' Perception on The Use of Dual-Coding Theory (DCT) in Reading Descriptive Texts

Abstract: This study aims to investigate seventh graders’ perception on the implementation of Dual-Coding Theory (DCT) in reading descriptive texts at MTsN 1 Kota Malang. It involved ten regular classes with a total of 296 students. The data were collected through questionnaires. The questionnaire consists of 20 statements with a 4-point Likert scale, concerning about the students’ opinion on (1) the effect of pictures on the students’ ability to conjure up objects, (2) the effect of pictures on their attitudes, and (3) the use of pictures in identifying word meaning and main idea. The findings show that the perception of the students on the use of DCT in reading descriptive text is positive. 91.3 percent students agree that the use of DCT contributes positively to the learning process. First, it helps students to imagine what is written in the descriptive text. Second, it attracts the students’ interest and increases their motivation to read descriptive text. Third, DCT helps students in identifying word meanings and its main ideas. Therefore, DCT is an effective method to enhance descriptive reading skill. Keywords: perception; reading comprehension; Dual-Coding Theory Abstrak: Penelitian ini bertujuan untuk mengetahui persepsi siswa kelas 7 MTsN 1 Kota Malang terhadap penggunaan Dual-Coding Theory (DCT) dalam membaca teks deskriptif. Kelas tersebut terdiri dari 10 kelas reguler yang berjumlah 296 siswa. Data diambil melalui kuesioner. Kuesioner terdiri dari 20 pernyataan dengan menggunakan skala Likert 4 poin, mengenai persepsi siswa pada (1) pengaruh gambar terhadap kemampuan siswa dalam membayangkan benda, (2) pengaruh gambar terhadap sikap siswa, dan (3) penggunaan gambar dalam mengidentifikasi makna kata dan gagasan utama. Hasil penelitian menunjukkan bahwa persepsi siswa tentang penggunaan DCT dalam membaca teks deskriptif adalah positif. 91,3 persen siswa setuju penggunaan DCT memberikan kontribusi positif terhadap proses pembelajaran. Pertama, membantu siswa untuk membayangkan apa yang tertulis dalam teks deskriptif. Kedua, menarik minat siswa dan meningkatkan motivasi mereka untuk membaca teks deskriptif. Ketiga, DCT membantu siswa dalam mengidentifikasi makna kata dan gagasan utamanya. Oleh karena itu, DCT merupakan metode yang efektif untuk meningkatkan keterampilan membaca teks deskriptif. Kata kunci: persepsi; pemahaman membaca; Dual-Coding Theory
Glycopolymer-Functionalized MOF-808 Nanoparticles as a Cancer-Targeted Dual Drug Delivery System for Carboplatin and Floxuridine

Codelivery of chemotherapeutics via nanomaterials has attracted much attention over the last decades due to improved drug delivery to tumor tissues, decreased systemic effects, and increased therapeutic efficacies. High porosities, large pore volumes and surface areas, and tunable structures have positioned metal–organic frameworks (MOFs) as promising drug delivery systems (DDSs). In particular, nanoscale Zr-linked MOFs such as MOF-808 offer notable advantages for biomedical applications such as high porosity, good stability, and biocompatibility. In this study, we report efficient dual drug delivery of floxuridine (FUDR) and carboplatin (CARB) loaded in MOF-808 nanoparticles to cancer cells. The nanoparticles were further functionalized by a poly(acrylic acid-mannose acrylamide) (PAAMAM) glycopolymer coating to obtain a highly selective DDS in cancer cells and enhance the therapeutic efficacy of chemotherapy. While MOF-808 was found to enhance the individual therapeutic effects of FUDR and CARB toward cancerous cells, combining FUDR and CARB was seen to cause a synergistic effect, further enhancing the cytotoxicity of the free drugs. Enhancement of CARB loading and therefore cytotoxicity of the CARB-loaded MOFs could be induced through a modified activation protocol, while coating of MOF-808 with the PAAMAM glycopolymer increased the uptake of the nanoparticles in cancer cells used in the study and offered a particularly significant selective drug delivery with high cytotoxicity in HepG2 human hepatocellular carcinoma cells. These results show how the enhancement of cytotoxicity is possible through both nanovector delivery and synergistic treatment, and that MOF-808 is a viable candidate for future drug delivery studies.