Miracle-dz/UniFAR-FTUs huggingface dataset:
Upregulation of SHMT2 Promotes Tumor Growth and Poor Prognosis of Breast Cancer through Activating VEGF and MAPK Signaling Pathway

Background: Serine hydroxymethyltransferase 2 (SHMT2) is a key enzyme in Serine/glycine metabolism. SHMT2 is very important for tumor cell growth and proliferation as well as metabolism. Here, we investigated the regulatory effects of SHMT2 on breast cancers growth and identified the underlying mechanisms of functions.Methods: We detected the expression of SHMT2 in breast cancer cells and tissues by immunohistochemistry and Western blotting.We investigated the functional and molecular mechanisms by which SHMT2 downregulation or overexpression regulates the growth and apoptosis of breast cancer cells in vivo and in vitro. Results: We found SHMT2 was highly expressed in BRCA cell lines and tumor tissues. Strong SHMT2 expression showed a positive correlation with the poor prognoses of patients with breast cancers. SHMT2 knockdown by shRNA significantly inhibited cell growth and induced apoptosis in vitro, and whereas SHMT2 overexpression promoted tumor growthin in subcutaneous xenograft model. RNA-seq revealed that high expression of SHMT2 not only promoted serine metabolism, nucleotide metabolism, oxidative phosphorylation and proteasome independent degradation pathways. It also activated the cell survival signaling pathway and antagonized the apoptosis pathway. The observed molecular regulation of cell growth was accompanied by the activited of the MAPK, VEGF pathways and suppressed of the mitochondrial mediated apoptosis pathway that was mediated by the SHMT2 up-regulation. Conclusions: These results indicate that SHMT2 plays a critical role in regulating breast cancers growth and could serve as a therapeutic target for breast cancer therapy.
Measuring The Effectiveness Of Service Convenience For Retail Stores Of Electronic Goods In Ahmedabad City

As organized retail grows, we expect the market to be more competitive by providing more choices to consumers and retailers. At this point, developers will have to work harder to create a differentiation for their product. We believe consumers The internal factor: effective mall management as a growing phenomenon in the Indian retail industry today. The prime objective of landlords as well as of investors is to attract shoppers and persuade them to purchase goods and services. This will in turn boost retailers " turnover and benefit their bottom line. Efficient mall management can help landlords achieve this goal. The concept of convenience first appeared in the marketing literature in relation to categories of products. Classification of consumer products included convenience goods: intensively distributed products that require minimal time and physical and mental effort to purchase. Service convenience: a multidimensional conceptualization Service convenience, as conceptualized by Berry et al. (2002, p. 4), is defined as the " consumers " time and effort perceptions related to buying or using a service. " Consumers experience an increase in time deficiency when conducting tasks related to the acquisition and consumption of a service
ANALYSIS OF DAILY MILK PRODUCTIVITY CHANGE IN DAIRY COWS

Summary. Research on fluctuations in cow milk productivity traits was carried out in July and August of the years 2001 and 2002, within a period of 30 days each year. Latvian Brown milking cows, 74 and 66 respectively, reared by one person, were included in trial group. Coefficients of variation were calculated for each cow for all the studied productivity traits to elicit dynamics of milk productivity traits. Dynamics of cow daily milk productivity was found higher in the year 2002. In both trial years greatest values of coefficients of variation were obtained for somatic cell count, 16.83% and 37.01% on average per group of cows. Lactose content in milk was most stable milk productivity trait. The observed variability was from 1.43% to 3.37%, however this difference was significant. The average variability in milk yield, fat and protein content in milk was 9.77%, 10.94% and 8.76% respectively in 2002. Physiological factors, such as cow age at lactations and lactation phase might be the factors, which could significantly affect milk productivity dynamics. Feed means used as supplement in cow diet as well as concentrated feed fed significantly affected dynamics of fat, protein and lactose content in milk. In analysis of the dynamics of the milk yield, fat and protein content in milk in different cow lactation phases we found that these traits could significantly change already in the following day of control. In second trial day, cows of the 1 st phase lactation showed significant change in average milk yield, fat and protein content in milk by 6%, 10% and 6% respectively compare to the first trial day.
Asking for help: restaurant crowdfunding during COVID-19

ABSTRACT The purpose of this study is to explore business crowdfunding donation campaigns in which there is no reward or incentive provided to the donor. Specifically, crowdfunding campaigns benefiting restaurants and their employees are examined in two large U.S. cities during the COVID-19 pandemic to determine whether the level of social embeddedness and the amount of social capital available to restaurants affected the amount donated. This study’s findings indicate that the social embeddedness for COVID-19 restaurant donation campaigns is not related to the amount donated. There is a significant difference in donation amounts for campaigns started by the restaurant owner or an individual connected to the restaurant compared to campaigns started by GoFundMe. There is also a significant difference in the amounts of funds donated and the number of shares made for campaigns in large population cities compared to those not in large cities. Examinations of donation campaigns for the benefit of businesses provide new insight into the use of this emerging financial platform, particularly in relation to social embeddedness and social resource theory.
Wideband bandpass filter with excellent selectivity using new CSRR-based resonator

A wideband bandpass filter (WBPF) with excellent selectivity is proposed. An equivalent circuit model of the new complementary split-ring resonator (CSRR)-based resonator with good wideband response is presented. A WBPF with strong passband selectivity and wide stopband can be achieved by the new resonators with a proper coupled scheme using the eighth-wavelength (λ/8) directly coupled parallel microstrip-lines. Specifically, the filter exhibits a competitive attenuation slope of 262.2 and 75.9 dB/GHz in the lower and upper passband transitions, respectively.
Application of clean algorithm in incomplete microtremors recordings

The reconstruction of gapped microtremors recordings with the aid of CLEAN algorithm, which originally developed for spectral analysis of unevenly spaced time series, is studied. As proved in previous relative studies the algorithm has the ability to "clean" the spectrum of a discrete signal from artifacts and additionally (through an Inverse DFT) to reconstruct the signal in time domain. We studied the algorithm's effectiveness of reconstruction in microtremors recordings. We saw that for continuous gap with length up to 10% of the total length of microtremor recording, the algorithm was able to reconstruct efficiently.
Optimal Energy-Effective Gait for Biped Robot

Although peoples legs are capable of a broad range of muscle-use and gait patterns, they generally prefer just two, walking and running. A popular hypothesis regarding legged locomotion is that humans and other large animals walk and run in a manner that minimizes the metabolic energy expenditure for locomotion. Here, a mathematical model for a simple two-dimensional planar kneed walker with point feet and two bended knees is discussed. An energy-effective gait is designed by using piecewise torque method. Then, the robot model can exhibit a natural and reasonable walk on a level ground. The results can prove that the proposed optimal energy-effective gait is suitable for this kneed biped walking robot. And we also discover some walking rules maybe true through the results of optimization.
Wideband Bezier curve shaped microstrip to H-guide transition

A new, wideband, low-loss, equal phase front Bezier curve shaped transition between a microstrip line and an H-guide embedded into a dielectric substrate is presented. A thin H-guide structure where the separation between metallic plates is much smaller than lambda 0 /2 is implemented. Cutoff frequencies and design considerations for forming this H-guide at microwave frequencies between 2 and 6 GHz are discussed. Simulated and measured results are presented and discussed, and a good agreement is shown.
Reduced Test Pattern Generation of Multiple SIC Vectors with Input and Output Delay Faults

In recent years, the design for low power has become one of the greatest challenges in high-performance very large scale integration (VLSI) design. Most of the methods focus on the power consumption during normal mode operation, while test mode operation has not normally been a predominant concern. However, it has been found that the power consumed during test mode operation is often much higher than during normal mode operation [1]. This is because most of the consumed power results from the switching activity in the nodes of the circuit under test (CUT), which is much higher during test mode than during normal mode operation [1]–[3]. In the proposed pattern, each generated vector applied to each scan chain is an SIC vector, which can minimize the input transition and reduce test power. In VLSI testing, power reduction is achieved by increasing the correlation between consecutive test patterns.
West Village Student Housing Phase I: Apartment Monitoring and Evaluation

Building America team Alliance for Residential Building Innovation (ARBI) worked with the University of California, Davis (UC Davis) and the developer partner West Village Community Partnership (WVCP) to evaluate performance on 192 student apartments completed in September, 2011 as part of Phase I of the multi-purpose West Village project. West Village, the largest planned zero net energy community in the United States. The campus neighborhood is designed to enable faculty, staff and students to affordably live near campus, take advantage of environmentally friendly transportation options, and participate fully in campus life. The aggressive energy efficiency measures that are incorporated in the design contribute to source energy reductions of 37% over the B10 Benchmark. The energy efficiency measures that are incorporated into these apartments include increased wall & attic insulation, high performance windows, high efficiency heat pumps for heating and cooling, central heat pump water heaters (HPWHs), 100% high efficacy lighting, and ENERGY STAR major appliances. Results discuss how measured energy use compares to modeling estimates over a 10 month monitoring period and includes a cost effective evaluation.
Out-of-phase Wilkinson power divider

A 1times2 Wilkinson power divider with 180deg phase difference between two outputs is presented. A slotline T-junction is employed in order to split an input signal into two outputs with the same amplitude and opposite phase relationship. A 25 Omega resistor is placed between two microstrip output sides and a ground plane in order to achieve a good match and complete isolation.
BIDENS FRONDOSA (ASTERACEAE), A NEW ALIEN INVASIVE PLANT SPECIES IN THE KURGAN REGION (RUSSIA)

The annual weed Bidens frondosa L. (Asteraceae) has been registered for the first time in the Kurgan Region in 2020 during research on the riverine vegetation of the southwestern part of Western Siberia. This invasive species was found in ten locations along the Iset River banks in the Kurgan Region. We have postulated that the Sverdlovsk Region serves as a source for the B. frondosa invasion into the Kurgan Region along the River Iset. Despite a single short-term field survey, B. frondosa was found in several sites. In the Kurgan Region, this invasive species is characterized by low population density in all plots. Since B. frondosa populations are characterized by much higher density in other regions of European Russia, an increase in the number of locations and density of populations is expected in the Kurgan Region in the future.
Ulva prolifera Monitoring Study in the Yellow Sea from Multi-Temporal Remote Sensing Images

Multi-temporal Moderate resolution Imaging Spectroradiometer (MODIS) remote sensing images were used to monitor the massive blooms of floating green tide algae Ulva prolifera in the midwest of Yellow Sea (YS). In addition, from the marine environment elements of sea surface temperature (SST) and sea surface wind field, the growth and drift characteristic of U. Prolifera were studied based on MODIS thermal infrared channel SST data and Windsat wind field data. In May 2014, U. Prolifera accumulation areas were first found in central YS north of Subei Bank. With summer arrival, seawater temperature of ocean surface gradually increased in YS, It provided a more suitable environment for the growth of U. Prolifera. Due to the prevailing northerly winds in central and western YS, U. Prolifera advected to the coastal waters of Shandong Peninsula, and spread to the northeastward. In late June, it had a massive bloom and reached the maximum coverage in the northern YS. The U. Prolifera drift characteristic was confirmed by the analysis on SST and sea surface wind field, and the result shows that under the environment of suitable sea surface temperature, the driving force of the prevailing sea surface wind field might be the main reason of YS U. Prolifera bloom occurrence.
Time series analysis-based adaptive tuning techniques for a heaving wave energy converter in irregular seas

Abstract The paper presents a time domain model of a heaving buoy wave-energy converter and investigates the tuning problem in irregular seas. The tuning issue is addressed by employing both fixed (passive) and adaptive (active) power-take-off settings. The fixed power-take-off tuning approach includes models based on tuning the device natural frequency to either the energy frequency or peak frequency of the sea-state or a weighted average of several peak frequencies. The adaptive tuning approaches employ a sliding discrete Fourier transform frequency analysis, or a time-series analysis of the measured wave elevation and device velocity to estimate a localized dominant wave frequency and hence calculate power-take-off settings. The paper presents details of these tuning techniques by discussing issues related to the modelling, simulation, and predicted power captures for each method. A comparative study of each method along with practical implications of the results and recommendations are also presented.
Assistant Model For Considering Slot-Opening Effect on No-load Air-gap Flux Density Distribution in Interior-type Permanent Magnet Motor

This paper proposes an effective assistant model for considering the stator slot-opening effect on air gap flux density distribution in conventional interior-type permanent magnet (IPM) motor. Different from the conventional slot-opening effect analysis in surface-type PM (SPM) motor, a composite effect of slot-opening uniquely existing in IPM motor, which additionally causes enhancement of air gap flux density due to magnet flux path distortion in iron core between the buried PM and rotor surface. This phenomenon is represented by a proposed assistant model, which simply deals with this additional effect by modifying magnetic pole-arc using an effective method. The validity of this proposed analytical model is applied to predict the air gap flux density distribution in an IPM motor model and confirmed by finite element method (FEM).
Comparator based self-trim and self-test scheme for arbitrary analogue on-chip values

Trimming is a ubiquitous element of many mixed-signal circuits. Already a long standing requirement of mixed-signal design trimming is made even more popular by shrinking design geometries with their associated variability make trimming even more popular. With increasing demand of trimming per chip, the ATE based trimming process is moved on-chip. The comparator based self-trim is the most common base for self-trim circuits due to its minimum overhead. Yet self-trim is not identical to self-test. Introduction of a simple fault model shows the blindness of the industrially important comparator based self-trimming to manufacturing faults. In order to preserve the simplicity of the comparator based trimming, a scheme is proposed which allows a complete self-test of both the comparator and the trim result. The paper also investigates the characteristics of the self-trimmed distribution and its consequences for the self-test scheme. Simulation and silicon results from industrial designs are presented
Identification of a genomic DNA sequence that quantitatively modulates KLF1 expression in differentiating human hematopoietic cells

Expression of the ß-like globin genes is under strict developmental control, with both direct and indirect inputs responsible for this effect. One of the major players regulating their transition is KLF1/EKLF, where even a two-fold difference in its level alters the regulation of globin switching. We have reproduced this change in KLF1 expression in both cell lines and primary human cells, thus demonstrating that directed, quantitative control of KLF1 expression can be attained by genomic manipulation, and suggest a new way in which modulation of transcription factor levels may be used for clinical benefit.
Lightning-induced voltages on overhead lines

A modeling procedure that permits calculation of lightning-induced voltages on overhead lines starting from the channel-base current is discussed. The procedure makes use of a coupling model already presented in the literature, based on transmission line theory, for field-to-overhead line coupling calculations. Both models are discussed and compared with experimental results. The hypothesis of perfect conducting ground, used to analyze the voltages induced on an overhead line by a nearby lightning return stroke with a striking point equidistant from the line terminations, and the limits of its validity are determined. A comparison shows that peak value and maximum front steepness of the induced voltages calculated using other lightning return-stroke models differ. It is also shown that another coupling model used in the power-lightning literature by several other authors may result in a less accurate estimation of the induced voltages. >
Host country national quality of interaction with expatriates: antecedents, process, and outcome

Abstract Little research examines host country national (HCN)-expatriate interaction from the HCN’s perspective. Our study contributes to theory and practice by introducing the concept of ‘HCN-expatriate interaction quality’, one that has received little attention in the literature. Drawing on the Intergroup Contact Theory, we examine the mediating role of HCN-expatriate interaction quality between the HCN’s on-the-job interaction with and support to the expatriate, as well as two moderating effects: off-the-job interaction with the expatriate and perceived expatriate receptivity towards support. Further, we examine how different types of the HCN’s prior international experiences enhance interaction quality with and support to the expatriate. Using a multi-wave design of HCNs in Taiwan, we find support for most of our hypotheses.
Digital innovation: transforming research and practice

ABSTRACT There is no doubt that digital technologies are spawning ongoing innovation across most if not all sectors of the economy and society. In this essay, we take stock of the characteristics of digital technologies that give rise to this new reality and introduce the papers in this special issue. In addition, we also highlight the unprecedent opportunities that digital innovation provides to study innovation processes more generally. Overall, we conclude that the speed, observability, and relative ease in investigating relationships between multiple analytical levels, mean that digital innovation is both a ‘model of’ that also provides a ‘model for’ the study of innovation processes more broadly in non-digital and hybrid contexts.
A Study on the Performance of ARC Pavement for Traffic Noise Reduction - A SPB Comparison with Conventional Pavement

This research investigates traffic noise reduction on highways paved with ARC material and establishes a quantitative model for evaluating the effect of traffic flow on traffic noise. A series of traffic noise measurements have been combined with traffic flow monitoring to compare the sound performance of ARC with conventional pavements and analyze the relationship between the noise levels over ARC pavement with traffic flow conditions. The 24-hour averaged Statistical Pass-By (SPB) noise levels indicate that the ARC pavement demonstrates better sound performance than that of conventional pavement in traffic noise reduction. The energetic averaging method is employed to study the relationship between traffic noise levels and traffic flow conditions. The applicability of ARC pavement to traffic noise reduction under various traffic fl ow conditions is also investigated. A relationship between traffic flow and traffic noise is established in terms of SPB noise levels and the traffic volumes for different vehicle categories. The relationship is employed to compare the noise reduction performance between ARC and conventional pavements under various traffic flow conditions. The research results indicate that ARC pavement is very effective at reducing the noise generated by large vehicles.
Effects of Mountains on Aerosols Determined by AERONET/DRAGON/J‐ALPS Measurements and Regional Model Simulations

The NASA/AErosol RObotic NETwork field campaign Distributed Regional Aerosol Gridded Observation Networks/Joint work to the AerosoL Properties and Process Simulations was conducted from March 2020 to May 2021 in Nagano, Japan. Twelve sun photometers were installed around Nagano prefecture. The effects of topography on aerosols were studied using observations and simulations. In this study, a regional chemical transport model (SCALE‐Chem) was employed. Three numerical experiments were conducted: E1 (control experiment), E2 (E1 without topography), and E3 (E1 with removal of all anthropogenic emissions over Nagano prefecture). In E2, the terrain effect was not considered; the difference between E1 and E2 indicated the influence of mountains. The differences between E1 and E3 evaluate the local emission effect. In some cases, the mountainous terrain seemed to have suppressed aerosol inflow (i.e., reduced aerosol concentration), while in other cases, the mountains contributed to aerosol retention on days when aerosols tended to accumulate in mountain basins due to local emissions. Thus, while mountains prevent the inflow of aerosols from outside, they also contribute to increased aerosol concentration in the basin. Naturally, more significant effects are produced by meteorological conditions and the presence or absence of transboundary pollution from the outside. From observations and model simulations, we found that the aerosol concentration was not high around the J‐ALPS site because of the mountain effect that prevents advection from the outside, even when transboundary pollution was observed in Japan in March 2020.