Miracle-dz/UniFAR-FTUs huggingface dataset:
Eine Frage der Zeit und Dosierung – intraarterielle Chemotherapie beim Oropharynxkarzinom

Zusammenfassung Einleitung Patienten mit Kopf-Hals-Tumoren erreichen durch die Standardtherapie gute Ansprechraten. Die Lebensqualität ist aber unter Radiochemotherapie oft sehr beeinträchtigt und Hauptgrund der hohen Suizidrate. In dieser Studie wird über die Behandlung von fortgeschrittenen Oropharynxkarzinomen des Stadiums IV mit intraarterieller Kurzzeit-Chemotherapie berichtet. Methoden 55 Patienten mit progredienten, inzwischen inoperablen Oropharynxkarzinomen des Stadiums IVA (n = 44), IVB (n = 4) und IVC (n = 7) wurden mit intraarterieller Kurzzeit-Chemotherapie (IAC) behandelt. Die IAC wurde niedrigdosiert entweder über einen Angiokatheter oder einen implantierten intraarteriellen Portkatheter über einen Zeitraum von 7–12 Minuten infundiert. Ausgeprägte Tumormassen, eine hohe Anzahl an metastasierten Lymphknoten oder Lungenmetastasen wurden mit zusätzlicher isolierter Thoraxperfusion behandelt. Ergebnis Unterschiedliche Überlebenszeiten wurden erreicht, je nach Vorbehandlung der Patienten. Die 1-, 2- und 3-Jahres-Überlebensraten lagen bei 76 %, 54 % und 35 % für nicht vorbestrahlte Tumoren und bei 40 %, 7 % und 7 % für vorbestrahlte Tumoren. Besonders gute Überlebenszeiten hatte die Untergruppe der zuvor behandelten, aber nicht bestrahlten Patienten mit Rezidiven (n = 8), welche eine mediane Überlebenszeit von 33,5 Monaten erreichten. Demgegenüber betrug die mediane Überlebenszeit der Patienten mit bestrahlten und rezidivierten Tumoren 8,2 Monate. Tracheostomien und Ernährungssonden wurden in allen Fällen vermieden. Diskussion Randomisierte klinische Studien sind nötig, um die Ergebnisse zu belegen. Die Gabe von kleinen Dosierungen in das begrenzte Volumen der Tumorregion erzeugt hohe Konzentrationen am Wirkort und damit eine verstärkte Wirkung.
Effect Analysis of Behavioral Change Strategy Applied to Nutritional Intervention in Patients with Pancreatic Ductal Adenocarcinoma

To investigate the effect of nutritional nurse-led multidisciplinary team on nutritional intervention for patients with pancreatic ductal adenocarcinoma (PDCA). Methods Using the behavioral change strategy as a framework, 50 patients were subjected to individualized dietary behavior intervention for 12 weeks. Results The multidisciplinary team led by nutrition nurses used behavior change strategies to significantly improve the nutritional status of pancreatic patients. The behavior change strategies combined clinical evidence provided evidence for evidence-based interventions. Conclusion Behavior change strategies which provide a theoretical framework for nursing interventions. Pancreatic ductal adenocarcinoma is one of the most malignant tumors. Official US data show that PDCA is expected to be the second leading cause of death by 2030 [2] . In China, the incidence of pancreatic cancer increased from 1.3% per year from 2000 to 2011 . As everyone knows, the main challenge facing people with cancer is the impact of the disease on nutritional status and ultimately the quality of life. The main feature of PDCA-induced malnutrition is weight loss, and it is multifaceted, including pancreatic insufficiency caused by cancer (including exocrine: steatosis; endocrine: diabetes) [5]. Weight loss is often the main cause of concern for patients, driving them to seek medical help again. Research reports indicate that the weight loss rate of PDCA patients is as high as 70% to 75%, and almost three-quarters of the subjects lose more than 5% of their weight [6] [7]. The MST malnutrition screening tool is a simple, fast, effective, and reliable tool developed by Ferguson [8] to identify patients at risk of malnutrition. It is recommended by the American Dietetic Association and can be used for adults Screening of nutritional risks for inpatients. There are two main problems, namely, changes in body weight and changes in dietary intake. The behavior change strategy [1] is a comprehensive, consensus intervention strategy for behavior change developed by the University of London's Department of Clinical, Educational and Health Psychology Research, which is a complex and interactive strategy [9]. Before the behavior change intervention, we must fully collect all the mechanisms that affect behavior change. The mechanisms are accumulated into useful information, including replication, evidence synthesis, implementation, and formation of activity plans. Interventions must be clear to ensure their effectiveness [10] [11]. 1 Method and Objects 2020 International Conference on Social and Human Sciences (ICSHS2020) DOI: 10.38007/Proceedings.0000175 ISBN: 978-1-80052-000-4 963 -
Collagen gel droplet embedded culture drug sensitivity test (CD-DST) for esophageal cancers

3617 Cisplatin (CDDP) and 5-fluorouracil (5-FU) are usually combined for treating esophageal squamous cell carcinoma (ESCC). Standard chemotherapy using CDDP and 5-FU was effective for ESCC and also established for neoadjuvant chemotherapy. Recently chemotherapy protocols using docetaxel (DOC) for ESCC also have been reported. But we cannot know whether chemotherapy is sensitive or not until the patient is treated with CDDP, 5-FU or DOC, and the patients have to waste time and suffer from side effect of chemotherapy if the chemotherapy is not sensitive. To evaluate chemotherapy sensitivity, collagen gel droplet embedded culture drug sensitivity test(CD-DST) for esophageal cancer was applied. This method consists of a collagen gel droplet embedded culture step, exposure and washout of anticancer drug, a serum-free culture step, and evaluation of anticancer effect, using small quantities of cells. CD-DST has many advantages including high primary culture success rates, the original growth characteristics of the cultured cells, easy quantification of the anticancer effects without contamination with fibroblasts by using an image analysis system. Our research subjects were 20 patients with esophageal cancer who had undergone operations between August 2004 and October 2005 in our department. CD-DST test was applied to 21 specimens including 20 patients with (19 ESCCs, 1 small cell carcinoma,1 adenocarcinoma). Interpretable results using CD-DST test were obtained from 55% (11/20) of tumor specimens studied. Chemosensitivities to CDDP, 5-FU or DOC of tumors were 75% (6/8): 5-FU 80%(8/10), CDDP 33%(2/6), 5-FU+CDDP 100%(1/1), DOC67%(2/3). Many investigators reported that using CD-DST, sensitivity based induction chemotherapy was successful in the patients. This method has an advantage of a good correlation between in vitro and in vivo results, and simplicity and speed. We therefore consider that the CD-DST can be used to predict the response to anti-cancer drugs, and may also provide important information by contributing to the development of new chemotherapy regimens and tailor-made therapy for neoadjuvant chemotherapy. Analysis of immunohistochemistry or mRNA expression levels of molecular markers associated with chemotherapy sensitivity were perfomed by CD-DST test, and there is a report of a good correlation between immunohistochemistry or cDNA mocroarray and CD-DST test. These results suggest that we can predict more available chemotherapy sensitivity by combined tests.
What is “The Energy-Water Nexus”?

The U.S. is a nation rich in energy, water, and other natural resources and it has aggressively harnessed many of these resources, both within our country and abroad. We have utilized these resources to become one of the wealthiest societies on earth. Our energy and water resources are essential to our economic and social wellbeing and to our national and economic security. As the U.S. population continues to increase and to migrate into more remote and extreme areas there will be ever-increasing demands for energy and water.
Stress Response in Swedish Ambulance Personnel Evaluated by Trier Social Stress Test

According to previous research, ambulance personnel often consider themselves as healthy, but at the same time several studies show that they suffer from several stress-related illnesses, take early retirement and even suffer early death. The aim of this study was to explore mental stress during the Trier Social Stress Test. Questions were whether heart rate measurement could replace cortisol concentration in saliva as an indicator of stress and if there were differences between genders. During 20 Trier Social Stress Tests heart rate and salivary cortisol concentrations were measured. Heart rate was measured every 15 seconds and salivary cortisol was collected at seven occasions. Fourteen men and six women (sixteen ambulance nurses and four paramedics) participated. A questionnaire with background data was collected. Statistical analysis used was non-parametric tests to adjust for misalignment. During the Trier Social Stress Test women had their highest salivary cortisol concentration before start of test while the maximum values for men were 10 to 20 minutes after start. In contrast, there was no difference in heart rhythm before, during and after test between genders. No correlation between heart rate and salivary cortisol was found. There was no significant difference in stress response according to personnel’s age or level of education. Women and men exhibit different hormonal stress responses when it comes to performing unfamiliar actions, something that has not been seen before. Since no correlation could be seen between heart rate and salivary cortisol concentration they cannot replace each other as indicators of stress.
Sediment Toxicity Testing for Prospective Risk Assessment—A New Framework and How to Establish It

ABSTRACT There is a recognized need to design a new framework for sediment toxicity testing that meets current scientific standards and regulatory requirements, such as reliable assessment of toxicity, which prevents any harmful effects on biodiversity, a strong capability to predict population- and community-level effects, and applicability of the results to decision-making. We propose a new framework for prospective sediment toxicity testing, and suggest solutions to the key methodological challenges that hinder establishment of this framework (comparison of sensitivities, design of test batteries, consideration of different exposure routes, extrapolations to population and community levels, use of test results for decision-making). The proposed framework consists of the following three units: test-battery system, higher-tier testing systems and additional ecological modeling, and a decision support system. The key methodologies proposed to establish this framework are compound-tailored test-battery use approach, relative sensitivity distribution analysis, toxicity tests that combine bacteria and arthropods, micro- and mesocosms studies, population and community models, and model-driven decision support systems. The proposed framework, as well as the key methods mentioned above, has the potential to improve not only prospective toxicity testing for sediments, but also ecological risk assessment in general.
A novel compact K band PBG microstrip structure band-pass filter

A novel K band band-pass filter based on photonic band-gap (PBG) is presented. The proposed structures exhibit low insertion loss, compact size, simple fabrication and slow-wave characteristics. Due to slow-wave characteristic, PBG structure minimizes the pass-band filter to one-tenth of conventional filters with spurious-free response and deep attenuation levels. The miniature band-pass filter was simulated, realized and measured. There is a good agreement between the experiment and simulation results had been achieved. Its center pass-band frequency of this filter is 25.2 GHz, and insertion loss is less than −4.5 dB.
Saliva Based Nano-Biosensors for Early Detection of Oral Squamous Cell Carcinoma

Objectives: To provide an update regarding the recent trends and advancements in the field of salivary nano-biosensors which are useful in diagnosis of oral squamous cell carcinoma? Materials and methods: Literature survey was carried out in March 2021 in electronic databases such as PubMed SCOPUS, EMBASE, COCHRANRE library, Science Direct using key words such as Biosensors and oral cancer, Salivary biosensors and oral squamous cell carcinoma etc. Articles published in English language from 2000 to March 2021 which fulfilled the objectives of the study were included. Results: The searches revealed 236 articles out of which 42 were selected after reading the full text articles. Saliva based diagnostics is also referred as liquid biopsy for its immense potential as it is economical, noninvasive and easy to collect and contains wide variety of biomarkers which can be detected by biosensors. The use of biosensors in oral cancer detection and monitoring holds vast potential. Biosensors can be designed to detect emerging cancer biomarkers and to determine staging of the disease and diagnosis. Even though there are wide varieties of biomarkers, only few biosensors have the potential to become point of care diagnostics of oral cancer. Conclusions: The technological advancements in recent times have enabled researchers to develop high throughput and sensitive biosensors to detect active biomarkers from saliva of oral cancer patients.
The implication of Innovation, Proactivity, Risk Taking, Artistic Orientation, and Financial Literacy on Creative Economy Business Performance During the Pandemic

This study aims to determine the Implication of innovation, proactivity, risk-taking, artistic orientation, and financial literacy on creative economy businesses during the COVID-19 pandemic. This was conducted on 120 creative economy businessmen in Bandar Lampung City, which is a miniature of Indonesia with multiethnic cultures. The results showed innovation is not significant, but proactive attitude, artistic orientation, and financial literacy have a significant implication on the performance of creative economic businesses during the Covid-19 pandemic.
Defect inspection by an active 3D multiresolution technique

Reliable inspection of large surfaces with low depth recovery error is needed in a wide variety of industrial applications, for example in external defect inspection in aeronautical surfaces. Active triangulation measurement systems with a rigid geometrical configuration are inappropriate for scanning large objects with low measuring tolerances due to the fixed ratio between the depth recovery error and the lateral extension. Therefore, with a rigid triangulation setup, if we are interested in defect inspection over extended surfaces then we have to assume errors proportional to the field of view that can preclude a precise local defect measurement. This problem can be solved by the use of multiresolution techniques. In this work we demonstrate the application of an active triangulation multiresolution method for defect inspection of large aeronautical panels. The technique is based on a standard camera-projector system used together with a second auxiliary camera that can move freely. The result is a global measurement with a superposed local measurement without any optimization, explicit registration or recalibration process. The presented results show that the depth recovery error of the local measurement permits the local defects measurement together with a wide-area inspection.
Normograms in Prenatal Life of Stomach and Urinary Bladder in the Second and Third Trimesters of Pregnancy

Abstract Aim The aim of this study was to prepare normograms for the fetal stomach, urinary bladder, and stomach to urinary bladder index in healthy fetuses. Material and methods The study was conducted based on the data extracted from the database of our tertiary center in the years 2016–2019. The study group, comprising 867 fetuses, demonstrated normal biometry and normal heart structure, normal heart function, no extracardiac malformations, and no extracardiac anomalies. The stomach to urinary bladder index was analyzed in the study group. The examinations were performed with the use of the following ultrasound machines: Voluson E10, Philips and Voluson Expert, with convex transabdominal transducers. Linear regression analysis based on Microsoft Excel was used for statistical analysis. Results The average size of the stomach in healthy fetuses between the 14–40th week of gestation was 18 mm (8–40 mm), the average urinary bladder measurement was 17 mm (15–42 mm), and the fetal stomach to urinary bladder index was constant: 1.26 (0.09–3.93). Conclusions The normograms for the stomach, urinary bladder and the stomach to urinary bladder index prepared based on our study group can contribute to an improvement in the accuracy of examination and provide an unified organization of the description of fetuses. These normograms constitute an additional marker for the assessment of fetal condition. A clear disproportion in the size of the urinary bladder and stomach can be helpful in terms of paying more attention to fetuses with untypical features in screening centers.
Landscape epidemiology of ash dieback

Ash dieback caused by Hymenoscyphus fraxineus, an invasive alien pathogen, has been severely damaging European ash populations. Nevertheless, a large range of disease severities was observed at the landscape scale in the field. Several studies suggested that environment, such as climate, site conditions or local tree cover strongly affects ash dieback. We characterized the landscape epidemiology of the disease at two stages of the invasion process with spatio-temporal models using Bayesian models fitted by Integrated Nested Laplace Approximation (INLA). We first analyzed the effect of landscape features on the disease arrival and establishment stage at the scale of a village in NE France in 2012, 2 years after first report of the disease in the area and then, on the disease development stage in 2016-18. Landscape features had little impact on the disease at the establishment stage but strongly determined it further development. The local fragmentation of the tree cover was the most important factor with trees isolated or in hedges in agricultural settings far less affected then trees in forest environment. We showed that they were subjected to different microclimate with higher crown temperatures unfavorable to the pathogen development. Furthermore, host density was important for disease development with ash at low density far less affected by ash dieback. Presence of ashes in the vicinity affected local disease severity up to several hundred meters. These results may help to develop management strategy for the disease.
Rotation Feature of Three-Dimensional Tile Self-Assembly Molecular Structure for Efficient Microprocessor Material

Future application of nanoscale tile self-assembly is the production of smaller, more efficient microprocessors.In this paper, a new three-dimensional tile self-assembly molecular structure is presented.The model adds rotation movement where large assemblies of nanoscale tile molecules can be moved around, analogous to molecular motors. We have showed the universalityof the new model and demonstrated that three-dimensional model is capable of simulating two-dimensional model. This paper also covers the details about path encoding. The encoding process makes use of edgecharactersof tilesto simplify the design.
Mobile-Health Applications for the Efficient Delivery of Health Care Facility to People with Dementia (PwD) and Support to Their Carers: A Survey

Dementia directly influences the quality of life of a person suffering from this chronic illness. The caregivers or carers of dementia people provide critical support to them but are subject to negative health outcomes because of burden and stress. The intervention of mobile health (mHealth) has become a fast-growing assistive technology (AT) in therapeutic treatment of individuals with chronic illness. The purpose of this comprehensive study is to identify, appraise, and synthesize the existing evidence on the use of mHealth applications (apps) as a healthcare resource for people with dementia and their caregivers. A review of both peer-reviewed and full-text literature was undertaken across five (05) electronic databases for checking the articles published during the last five years (between 2014 and 2018). Out of 6195 searches yielded articles, 17 were quantified according to inclusion and exclusion criteria. The included studies distinguish between five categories, viz., (1) cognitive training and daily living, (2) screening, (3) health and safety monitoring, (4) leisure and socialization, and (5) navigation. Furthermore, two most popular commercial app stores, i.e., Google Play Store and Apple App Store, were searched for finding mHealth based dementia apps for PwD and their caregivers. Initial search generated 356 apps with thirty-five (35) meeting the defined inclusion and exclusion criteria. After shortlisting of mobile applications, it is observed that these existing apps generally addressed different dementia specific aspects overlying with the identified categories in research articles. The comprehensive study concluded that mobile health apps appear as feasible AT intervention for PwD and their carers irrespective of limited available research, but these apps have potential to provide different resources and strategies to help this community.
Electrical energy storage at the turn of the Millennium

Electrical energy storage is currently enjoying a considerable resurgence of interest, aided both by advances in the systems technologies themselves and also by fundamental changes in electricity markets, allowing the benefits of storage to be move clearly identified. This article, which introduces a special feature on "electrical energy storage", reviews the state of the art and developments into the next Century, existing and potential applications, market potential for utilities and users and the increasing attention from Government agencies, manufacturing industry and research organisations. It concludes that the forthcoming challenge is for the various systems to prove both their technical and their commercial viability.