Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Menyama Braya Culture and Social Capital on Family Welfare

According to economic development theory, a country's economic development is determined by social and cultural factors. Gotong royong is a valuable ancestral heritage in Indonesian culture. The purpose of this study is to examine how social capital and community togetherness are implemented in Bali through the Menyama Braya Culture, in order to benefit families and improve their welfare. This study employs a descriptive method to examine the welfare and culture of Menyama Braya in Bali, as evidenced by mutual cooperation during ceremonies, both god and human yadnya. The analysis's findings indicate that Balinese Hindu traditional and religious rituals generally have a beneficial effect on people's incomes and levels of happiness. The application of social capital as embodied in the Menyama Braya Culture may imply a recommendation that the Menyama Braya Culture be preserved as a local culture because it embodies the social capital that can prosper the family.
Mini-Track: Analytical Software Project Management

Software project management deals with software projects and the challenges of human-based development (as opposed to the more deterministic processes in traditional projects). The higher flexibility in software development approaches puts new demands on the capabilities of software project management. Weaknesses in planning, organizing, staffing, directing, and controlling are hard to be counterbalanced by more efficiency in technical development work. As Fred Brooks stated “. today’s major problems with software development are not technical problems, but management problems” (Brooks 1987). The principal nature of the challenges in software project management has not changed dramatically in the last 25 years. However, software-intensive systems of the twenty-first century increasingly vary in their content, size, complexity, and their degree of interaction with other systems. The technological and communication infrastructure to develop these systems is hard to compare with that available in the past. As a consequence, the concrete content of the project management challenges looks different from that of 25 years ago (Ruhe & Wohlin 2014). Proper management of software project has been proven of pivotal importance for success. Predictive analytics based on a variety of inform action sources (project repositories, crowdsourcing, internet, intranet) is expected to gain new and real‐time insight into the factors impacting software project success. In this mini‐track, we study research papers and experience reports that describe how analytical methods (including measurement, data analytics, reasoning, optimization, simulation) facilitate software project management. In particular, the following topics are planned to be covered:  Project management methods, tools and techniques for different paradigms of software development (from highly predictive to highly adaptive)  Predictive analytics (effort, defects) and its usage for software project management  Analytical methods in the context of the ten knowledge areas of software project management, in particular related to Time management Cost and effort management Human resource management Communications management Risk management  Project portfolio management  Real‐time decision‐making  Collaboration with the means of virtual teams and social networks  Capture and reuse of project knowledge  Dashboards and project intelligence  Industrial case studies
Glutamate dehydrogenase 1 mediated glutaminolysis sustains HCC cells survival under glucose deprivation

Besides aerobic glycolysis, glutaminolysis has also become a hot spot in the field of tumor research because of its important role in regulating cell proliferation, apoptosis, and migration and invasion. Meanwhile, it is generally believed that tumor cells could sustain its proliferation and survival according to a so-called metabolic flexibility. How the metabolic flexibility of HCC cells behaves has not yet been fully elucidated. In this study, we validated the glutamine addiction of HCC cells, and identified that the glutaminolysis pathway of HCC cells altered in response to different glucose conditions. That is, glutamate transaminases GOT1 pathway played a dominant role in regulating cell growth when glucose was sufficient, yet deaminase GDH1 mediated metabolic pathway became dominant when glucose was limited, for the reason that GDH1 could drive the TCA cycle in response to glucose deprivation. Additionally, we further uncovered an negative relationship between GDH1 and GOT1 in low-glucose HCC tissues. Together, our study provided a new insight into the metabolic flexibility of glutaminolysis related enzymes in HCC, and highlighted the crucial role of GDH1 on HCC cells proliferation and survival in glucose starvation.
Atmospheric Chemistry of Oxalate: Insight Into the Role of Relative Humidity and Aerosol Acidity From High‐Resolution Observation

Oxalate is the product of the precursors that can eventually be oxidized into oxalate by atmospheric oxidants (O3, etc.) and then redistributed to the particle phase, which has an impact on acid rain, and even the climate. However, we are still unclear about the influence of typical atmospheric oxidants in different phases with different RH and pH on oxalates. Here, we analyzed the effects of typical oxidants at RH ≤ 30%, 30% < RH ≤ 80% of the atmosphere on oxalates in atmospheric particulates based on high‐resolution online observation in Nanjing: the chemical processes of O3, OX (=O3 + NO2), and Cl− in different RH all have an important influence on the oxalate level, especially at 30% < RH ≤ 80% with high humidity have greater influence. NO2 only affects the particulate oxalate at RH ≤ 30%; HONO shows a greater effect at RH ≤ 30%, and 30% < RH ≤ 80% in winter and summer, the atmospheric oxidants that dust participates in have little effect. At the same time, we also found the difference between the influence of pH on atmospheric oxalate in winter and summer at RH > 80%, among which high pH is beneficial to the formation of oxalate in summer, while in winter has a greater influence on oxalate at RH ≤ 30%. These results help us to systematically understand the influence and distribution of oxalate in the atmosphere by RH, pH, and typical atmospheric oxidants.
Characterization of Cyanobacterial Communities in Lakes Requires Consideration of Diurnal and Spatial Variation

Continental-scale increases in aquatic system eutrophication are linked with increased cyanobacteria threats to recreational water use and drinking water resources globally. While some guidance regarding monitoring is available, it is largely reactive and insufficient for proactive risk mitigation and management, which necessarily requires an understanding of the composition and dynamics of cyanobacterial communities in the aquatic system. Their distribution is impacted by several factors, including water column mixing and buoyancy regulation responses to light availability that create oscillatory diurnal migration patterns within the water column, creating challenges in the ability to accurately describe and quantify cyanobacterial densities. These dynamic fluctuations are not typically reflected in monitoring protocols, which frequently focus on surface depths and either ignore sampling time or recommend large midday timeframes (e.g., 10AM-3PM), thereby precluding accurate characterization of cyanobacterial communities. While diurnal vertical migration of cyanobacteria has been reported in marine and eutrophic freshwater systems, reports in oligotrophic freshwater lakes are scant and characterization have focused on individual 24-hour periods neglecting to consider day-to-day variability. These dynamics must be better understood and reflected in water quality monitoring guidance to advance drinking water risk management and source water protection approaches. To evaluate the impact of diurnal migrations and water column stratification on cyanobacterial abundance, communities were characterized using a multi-time point sampling series across a 48-hour period in a shallow well-mixed lake interconnected to a thermally stratified lake in the Turkey Lakes Watershed (Ontario, Canada). Amplicon sequencing of the V4 region in the 16S rRNA gene was performed to characterize microbial community composition. Cyanobacteria were significantly represented in the microbial community in the midday and afternoon sampling times in the thermally stratified lake, but not in the well-mixed lake. Although the lakes in this study are interconnected, the cyanobacterial communities within them exhibited unique composition and distribution trends, thereby underscoring the importance of developing detailed sampling guidance to maximize the utility of cyanobacteria monitoring and better characterize and mitigate risk.
Novel Porcine Circoviruses in View of Lessons Learned from Porcine Circovirus Type 2-Epidemiology and Threat to Pigs and Other Species

Porcine circovirus type 2 (PCV2) plays a key role in PCV2-associated disease (PCVAD) etiology and has yielded significant losses in the pig husbandry in the last 20 years. However, the impact of two recently described species of porcine circoviruses, PCV3 and PCV4, on the pork industry remains unknown. The presence of PCV3 has been associated with several clinical presentations in pigs. Reproductive failure and multisystemic inflammation have been reported most consistently. The clinical symptoms, anatomopathological changes and interaction with other pathogens during PCV3 infection in pigs indicate that PCV3 might be pathogenic for these animals and can cause economic losses in the swine industry similar to PCV2, which makes PCV3 worth including in the differential list as a cause of clinical disorders in reproductive swine herds. Moreover, subsequent studies indicate interspecies transmission and worldwide spreading of PCV3. To date, research related to PCV3 and PCV4 vaccine design is at early stage, and numerous aspects regarding immune response and virus characteristics remain unknown.
Isothermal austenite to ferrite transformation: analysis of dilatation data

ABSTRACT A method of analysis of dilatation data developed earlier has been adapted and applied to study the isothermal transformation of austenite to ferrite in three experimental steels. Good match obtained between the amount of ferrite measured from the optical microstructures and the corresponding values evaluated from the analysis of the experimental dilatation curves validates the accuracy of the new method.
Analysis of defects associated with leaks on skid steer loaders

The CNH Wichita Product Center has had a chronic leak problem with the Skid Steer Loaders. The objective of this project was to analyze the manufacturing plant leak data and make improvements to correct the issue. The objective is twofold: 1) to make process or design improvements on current products produced in the plant and 2) to make recommendations for future designs to prevent such leak issues from reoccurring. The manufacturing data had to be transformed into usable form and then it was analyzed mostly by utilizing Pareto Charts. The highest six problem leak points were chosen from the manufacturing data. Process changes were implemented on these particular leak joints and the results were analyzed using two proportions hypothesis tests. The process changes reduced the leak rate by an average percent reduction of 86 percent. The process changes implemented will also be applied to other similar joints, and results documented in the future. The future design recommendations made from the analyzed data included the increased use of o-ring face seal connections at certain locations and where possible, reducing the number of joints per machine.
Influence of Hypoxia on Radiosensitization of Cancer Cells by 5-Bromo-2′-deoxyuridine

Radiotherapy is a crucial cancer treatment, but its outcome is still far from satisfactory. One of the reasons that cancer cells show resistance to ionizing radiation is hypoxia, defined as a low level of oxygenation, which is typical for solid tumors. In the hypoxic environment, cancer cells are 2–3 times more resistant to ionizing radiation than normoxic cells. To overcome this important impediment, radiosensitizers should be introduced to cancer therapy. When modified with an electrophilic substituent, nucleosides may undergo efficient dissociative electron attachment (DEA) that leaves behind nucleoside radicals, which, in secondary reactions, are able to induce DNA damage, leading to cancer cell death. We report the radiosensitizing effect of one of the best-known DEA-type radiosensitizers—5-bromo-2′-deoxyuridine (BrdU)—on breast (MCF-7) and prostate (PC3) cancer cells under both normoxia and hypoxia. MCF-7 and PC3 cells were treated with BrdU to investigate the effect of hypoxia on cell proliferation, incorporation into DNA and radiosensitivity. While the oxygen concentration did not significantly affect the efficiency of BrdU incorporation into DNA or the proliferation of tumor cells, the radiosensitizing effect of BrdU on hypoxic cells was more evident than on normoxic cells. Further mechanistic studies performed with the use of flow cytometry showed that under hypoxia, BrdU increased the level of histone H2A.X phosphorylation after X-ray exposure to a greater extent than under normal oxygenation conditions. These results confirm that the formation of double-strand breaks in hypoxic BrdU-treated cancer cells is more efficient. In addition, by performing stationary radiolysis of BrdU solution in the presence of an ●OH radical scavenger, we compared the degree of its electron-induced degradation under aerobic and anaerobic conditions. It was determined that radiodegradation under anaerobic conditions was almost twice as high as that under aerobic conditions.
Effect of Non-Parallel Combs of the Capacitive Micro-Sensor on the Pulse Signal Response

The effect of non-parallel combs of the micromechanical sensor on the reliable operation condition in three capacitive accelerometer configurations is investigated.The model for analyzing the effect of non-parallel combs is found.It is found that at the same drive voltage,the reliable operation ranges of the sensors for the single capacitor,double-sided capacitor and force-balanced capacitor are diminished to 0.34,0.44,0.52,respectively when the angle of decline is changed from 0° to 0.5°. The method to diminish the effect of non-parallel is also investigated.
The Effect of Corporate Social Responsibility on Brand Awareness: Evidence from the Insurance Sector in Zimbabwe

The aim of this study was to establish the eff ect of corporate social responsibility (donations, sponsorship and community involvement) on brand awareness within the insurance sector in Zimbabwe. Data was gathered from 350 insurance customers using a structured questionnaire with Likert-type questions. The fi ndings show that corporate social responsibility positively infl uences brand awareness. The study contributes to studies that proved a signifi cant relationship between corporate social responsibility and brand awareness in sectors other than the insurance sector. Thus, insurance fi rms are advised to seriously plough back proceeds to their communities.
Permanent Pacemaker Implantation Through Persistent Left Superior Vena Cava

The left superior vena cava is a persistent embryo-genetic variant, occurring in 0.3 to 0.5% of individuals in which the venous blood of the upper half of the body is drained through a left vena cava into the coronary sinus and/or through the atrio-ventricular groove in the right atrium. We present a case of incidental finding of persistent left superior vena cava (PLSVC) in a 70 years female who was being implanted with a single chamber pacemaker for complete heart block.
Resolving temperature limitation on spring productivity in an evergreen conifer forest using a model–data fusion framework

Abstract. The flow of carbon through terrestrial ecosystems and the response to climate are critical but highly uncertain processes in the global carbon cycle. However, with a rapidly expanding array of in situ and satellite data, there is an opportunity to improve our mechanistic understanding of the carbon (C) cycle's response to land use and climate change. Uncertainty in temperature limitation on productivity poses a significant challenge to predicting the response of ecosystem carbon fluxes to a changing climate. Here we diagnose and quantitatively resolve environmental limitations on the growing-season onset of gross primary production (GPP) using nearly 2 decades of meteorological and C flux data (2000–2018) at a subalpine evergreen forest in Colorado, USA. We implement the CARbon DAta-MOdel fraMework (CARDAMOM) model–data fusion network to resolve the temperature sensitivity of spring GPP. To capture a GPP temperature limitation – a critical component of the integrated sensitivity of GPP to temperature – we introduced a cold-temperature scaling function in CARDAMOM to regulate photosynthetic productivity. We found that GPP was gradually inhibited at temperatures below 6.0 ∘C (±2.6 ∘C) and completely inhibited below −7.1 ∘C (±1.1 ∘C). The addition of this scaling factor improved the model's ability to replicate spring GPP at interannual and decadal timescales (r=0.88), relative to the nominal CARDAMOM configuration (r=0.47), and improved spring GPP model predictability outside of the data assimilation training period (r=0.88). While cold-temperature limitation has an important influence on spring GPP, it does not have a significant impact on integrated growing-season GPP, revealing that other environmental controls, such as precipitation, play a more important role in annual productivity. This study highlights growing-season onset temperature as a key limiting factor for spring growth in winter-dormant evergreen forests, which is critical in understanding future responses to climate change.
Relevant Aspects of Piranha Passivation in Ti6Al4V Alloy Dental Meshes

Passivation of titanium alloy dental meshes cleans their surface and forms a thin layer of protective oxide (TiO2) on the surface of the material to improve resistance to corrosion and prevent release of ions to the physiological environment. The most common chemical agent for the passivation process of titanium meshes is hydrochloric acid (HCl). In this work, we introduce the use of Piranha solution (H2SO4 and H2O2) as a passivating and bactericidal agent for metallic dental meshes. Meshes of grade 5 titanium alloy (Ti6Al4V) were tested after different treatments: as-received control (Ctr), passivated by HCl, and passivated by Piranha solution. Physical-chemical characterization of all treated surfaces was carried out by scanning electron microscopy (SEM), confocal microscopy and sessile drop goniometry to assess meshes’ topography, elemental composition, roughness, wettability and surface free energy, that is, relevant properties with potential effects for the biological response of the material. Moreover, open circuit potential and potentiodynamic tests were carried out to evaluate the corrosion behavior of the differently-treated meshes under physiological conditions. Ion release tests were conducted using Inductively Coupled Plasma mass spectrometry (ICP-MS). The antibacterial activity by prevention of bacterial adhesion tests on the meshes was performed for two different bacterial strains, Pseudomonas aeruginosa (Gram-) and Streptococcus sanguinis (Gram+). Additionally, a bacterial viability study was performed with the LIVE/DEAD test. We complemented the antibacterial study by counting cells attached to the surface of the meshes visualized by SEM. Our results showed that the passivation of titanium meshes with Piranha solution improved their hydrophilicity and conferred a notably higher bactericidal activity in comparison with the meshes passivated with HCl. This unique response can be attributed to differences in the obtained nanotextures of the TiO2 layer. However, Piranha solution treatment decreased electrochemical stability and increased ion release as a result of the porous coating formed on the treated surfaces, which can compromise their corrosion resistance. Framed by the limitations of this work, we conclude that using Piranha solution is a viable alternative method for passivating titanium dental meshes with beneficial antibacterial properties that merits further validation for its translation as a treatment applied to clinically-used meshes.
Novel mutation in ODF2 causes multiple morphological abnormalities of the sperm flagella in an infertile male

Numerous genes have been associated with multiple morphological abnormalities of the sperm flagella (MMAF), which cause severe asthenozoospermia and lead to male infertility, while the causes of approximately 50% of MMAF cases remain unclear. To reveal the genetic causes of MMAF in an infertile patient, whole-exome sequencing was performed to screen for pathogenic genes, and electron microscope was used to reveal the sperm flagellar ultrastructure. A novel heterozygous missense mutation in the outer dense fiber protein 2 (ODF2) gene was detected, which was inherited from the patient's mother and predicted to be potentially damaging. Transmission electron microscopy revealed that the outer dense fibers were defective in the patient's sperm tail, which was similar to that of the reported heterozygous Odf2 mutation mouse. Immunostaining of ODF2 showed severe ODF2 expression defects in the patient's sperm. Therefore, it was concluded that the heterozygous mutation in ODF2 caused MMAF in this case. To evaluate the possibility of assisted reproductive technology (ART) treatment for this patient, intracytoplasmic sperm injection (ICSI) was performed, with the help of a hypo-osmotic swelling test and laser-assisted immotile sperm selection (LAISS) for available sperm screening, and artificial oocyte activation with ionomycin was applied to improve the fertilization rate. Four ICSI cycles were performed, and live birth was achieved in the LAISS-applied cycle, suggesting that LAISS would be valuable in ART treatment for MMAF.
A 900 MHz, Wide-Input Range, High-Efficiency, Differential CMOS Rectifier for Ambient Wireless Powering

This paper presents a wide dynamic-range CMOS rectifier with high efficiency and high sensitivity for RF energy harvesting. A new adaptive-biasing scheme is implemented using stacking diodes with dynamic threshold voltage to mitigate the reverse-leakage current of the NMOS rectifying devices at high RF power levels. The proposed design employs the adaptive-biasing technique to control the conduction of the PMOS rectifying devices with self-bulk biasing of the feedback diodes to minimize the leakage current. The proposed novel techniques extend the dynamic range of the RF-to-DC power converter with high efficiency, which is 17 times better than a conventional cross-coupled rectifier. The prototype is implemented using a standard 65 nm CMOS technology and occupies a 0.0093 mm2 active area. The proposed design achieves a peak power conversion efficiency (peak PCE) of 73%, −18.8 dBm 1-V sensitivity, and a superb dynamic range of 17.3 dB with efficiency greater than 80% of its peak PCE, which outperforms the state-of-the-art RF CMOS rectifiers, when operating at UHF 900 MHz with a 100-KΩ load.