Miracle-dz/UniFAR-FTUs huggingface dataset:
Cost-effectiveness analysis of a hand hygiene monitoring system in a tertiary pediatric hospital in Mexico

Background An automated hand-hygiene monitoring system (AHHMS) was implemented in October 2019 at the Hospital Infantil de México Federico Gómez (HIMFG), a tertiary pediatric referral hospital, in four of the hospital wards with the highest rates of Healthcare Associated Infections (HAIs). The clinical and economic impact of this system had not yet been assessed prior to this study. This study aimed to evaluate if the AHHMS is a cost-effective alternative in reducing HAIs in the HIMFG. Methodology A full cost-effectiveness economic assessment was carried out for the hospital. The alternatives assessed were AHHMS implementation vis-a-vis AHHMS non-implementation (historical tendency). The outcomes of interest were infection rate per 1,000 patient-days and cost savings as a result of prevented infections. Infection rate data per 1,000 patient-days (PD) were obtained from the hospital's Department of Epidemiology with respect to the AHHMS. As regards historical tendency, an infection-rate model was designed for the most recent 6-year period. Infection costs were obtained from a review of available literature on the subject, and the cost of the implemented AHHMS was provided by the hospital. The assessment period was 6 months. The incremental cost-effectiveness ratio was estimated. Costs are reported in US Dollars (2021). Univariate sensitivity and threshold analysis for different parameters was conducted. Results The total estimated cost of the AHHMS alternative represented potential savings of $308,927–$546,795 US Dollars compared to non-implementation of the system (US$464,102 v. US$773,029–$1,010,898) for the period. AHHMS effectiveness was reflected in a diminished number of infections, 46–79 (−43.4–56.7%) compared to non-implementation (60 v. 106-139 infections). Conclusion The AHHMS was found to be a cost-saving alternative for the HIMFG given its cost-effectiveness and lower cost vis-a-vis the alternate option. Accordingly, the recommendation was made of extending its use to other areas in the hospital.
Modeling the Variability of Drop Size Distributions in Space and Time

Abstract The information on the time variability of drop size distributions (DSDs) as seen by a disdrometer is used to illustrate the structure of uncertainty in radar estimates of precipitation. Based on this, a method to generate the space–time variability of the distributions of the size of raindrops is developed. The model generates one moment of DSDs that is conditioned on another moment of DSDs; in particular, radar reflectivity Z is used to obtain rainfall rate R. Based on the fact that two moments of the DSDs are sufficient to capture most of the DSD variability, the model can be used to calculate DSDs and other moments of interest of the DSD. A deterministic component of the precipitation field is obtained from a fixed R–Z relationship. Two different components of DSD variability are added to the deterministic precipitation field. The first represents the systematic departures from the fixed R–Z relationship that are expected from different regimes of precipitation. This is generated using a simp.
Specifics and Challenges to Flexible Organic Light-Emitting Devices

Several recent developments in material science and deposition methods for flexible organic light-emitting devices (OLEDs) are surveyed. The commonly used plastic substrates are compared, according to their mechanical, optical, thermal, and chemical properties. Multilayer electrode structures, used as transparent electrodes, replacing conventional indium tin oxide (ITO) are presented and data about their conductivity, transparency, and bending ability are provided. Attention is paid to some of the most popular industrial processes for flexible OLEDs manufacturing, such as roll-to-roll printing, inkjet printing, and screen printing. Main specifics and challenges, related to the foils reliability, mechanical stability of the transparent electrodes, and deposition and patterning of organic emissive films, are discussed.
The Extreme-Ultraviolet Solar Irradiance Spectrum Observed with the Coronal Diagnostic Spectrometer (CDS) on SOHO

We present a calibrated solar EUV irradiance spectrum in the ranges 307-380 Å and 515-632 Å. The "Sun as a star" spectrum was recorded by the Coronal Diagnostic Spectrometer (CDS) on SOHO on 1997 May 15 using the normal incidence spectrometer (NIS) with a spectral resolution between 0.3 and 0.6 Å. The relatively high spectral resolution allows the separation of blends and the differentiation of weak emission lines. The full-disk spectrum is compared with simultaneous well-calibrated EUV irradiance measurements from a NASA/LASP rocket payload to validate the preflight calibration of CDS. Significant errors in the preflight calibration were found, and a new calibration has been established for the CDS/NIS system. The present spectrum includes emission lines formed in the temperature range 104 to over 106 K. Line fluxes for the most prominent lines are extracted for the calibration and for the solar irradiance studies. This measurement should represent well solar minimum conditions as the daily 10.7 cm radio flux was 73 (units of 10-22 W m-2 Hz-1). A modest spatial resolution, constrained by the observing mode used, allows for the discrimination between quiet and active sun. The calibrated quiet-Sun irradiance spectrum is compared with previous measurements.
Observation Of Underlayer Domain Noise In Perpendicular Recording Discs

The authors employed a disk test system to extract samples of media noise from dual layer perpendicular recording disks. The samples of the media noise show it to have a distinct high and low frequency structure. The high frequency structure is the noise arising from the micromagnetics of the CoCr recording layer. The low frequency structure does not arise from the recording layer but from the NiFe underlayer. Using an imaging technique, the underlayer noise is characterized by lines that span inwards from the outside diameter of the disk. The appearance and behavior of these lines shows them to be attributable to domain walls in the underlayer of the disk. >
Payload Release Profile and Anti-Cancer Stem Cell Properties of Compositionally Different Polymeric Nanoparticles Containing a Copper(II) Complex

Cancer stem cells (CSCs) are linked to tumour relapse and metastasis, the main reason for cancer-related deaths. The application of polymeric nanoparticles as drug delivery systems to target CSCs is relatively unexplored. Here, we report the encapsulation of a CSC-potent copper(II) complex 1 by two compositionally different methoxy poly(ethylene glycol)-b-poly(D,L-lactic-co-glycolic) acid (PEG–PLGA) copolymers. Specifically, we used PEG–PLGA (5000:10,000 Da, 1:1 LA:GA) and PEG–PLGA (5000:10,000 Da, 4:1 LA:GA) polymers to prepare spherical nanoparticle formulations 1:1 NP15 and 4:1 NP15, respectively, both with a 15% feed of 1. The two formulations show distinct biophysical and in vitro properties. For example, (i) 4:1 NP15 displays a slower payload release profile than 1:1 NP15 in physiologically relevant solutions, (ii) 4:1 NP15 exhibits statistically greater potency towards breast CSCs than bulk breast cancer cells grown in monolayers, whereas 1:1 NP15 is equally potent towards breast CSCs and bulk breast cancer cells, and (iii) 4:1 NP15 shows significantly greater potency towards three-dimensionally cultured mammospheres than 1:1 NP15. This study shows that the release profile and anti-breast CSC properties of PEG–PLGA nanoparticle formulations (containing 1) can be perturbed (and possibly controlled) by modifying the proportion of glycolic acid within the PLGA component.
Representation of electromagnetic fields over arbitrary surfaces by a finite and nonredundant number of samples

It is shown that the electromagnetic (EM) field, radiated or scattered by bounded sources, can be accurately represented over a substantially arbitrary surface by a finite number of samples even when the observation domain is unbounded. The number of required samples is nonredundant and essentially coincident with the number of degrees of freedom of the field. This result relies on the extraction of a proper phase factor from the field expression and on the use of appropriate coordinates to parameterize the domain. It is demonstrated that the number of degrees of freedom is independent of the observation domain and depends only on the source geometry. The case of spheroidal sources and observation domains with rotational symmetry is analyzed in detail and the particular cases of spherical and planar sources are explicitly considered. For these geometries, precise and fast sampling algorithms of central type are presented, which allow an efficient recovery of EM fields from a nonredundant finite number of samples. Such algorithms are stable with respect to random errors affecting the data.
An historical overview of cavity-enhanced methods

An historical overview of laser-based, spectroscopic methods that employ high-finesse optical resonators is presented. The overview begins with the early work in atomic absorption (1962) and optical cavities (1974) that led to the first mirror reflectivity measurements in 1980. This paper concludes with very recent extensions of cavity-enhanced methods for the study of condensed-phase media and biological systems. Methods described here include cavity ring-down spectroscopy, integrated cavity output spectroscopy, and noise-immune cavity-enhanced optical heterodyne molecular spectroscopy. Given the explosive growth of the field over the past decade, this review does not attempt to present a comprehensive bibliography of all work published in cavity-enhanced spectroscopy, but rather strives to illustrate the rich history, creative diversity, and broad applications potential of these methods. PACS No.: 39.30. +w
Surviving without oxygen involves major tissue specific changes in the proteome of crucian carp (Carassius carassius)

The crucian carp (Carassius carassius) can survive complete oxygen depletion (anoxia) for several months at low temperatures, making it an excellent model for studying molecular adaptations to anoxia. Still, little is known about how its global proteome responds to anoxia and reoxygenation. By applying mass spectrometry-based proteome analyses on brain, heart and liver tissue from crucian carp exposed to normoxia, five days anoxia, and reoxygenation, we found major changes in particularly cardiac and hepatic protein levels in response to anoxia and reoxygenation. These included tissue-specific differences in mitochondrial proteins involved in aerobic respiration and mitochondrial membrane integrity. Enzymes in the electron transport system (ETS) decreased in heart and increased massively in liver during anoxia and reoxygenation but did not change in the brain. Importantly, the data support a special role for the liver in succinate handling upon reoxygenation, as suggested by a drastic increase of components of the ETS and uncoupling protein 2, which could allow for succinate metabolism without excessive formation of reactive oxygen species (ROS). Also during reoxygenation, the levels of proteins involved in the cristae junction organization of the mitochondria changed in the heart, possibly functioning to suppress ROS formation. Furthermore, proteins involved in immune (complement) system activation changed in the anoxic heart compared to normoxic controls. The results emphasize that responses to anoxia are highly tissue-specific and related to organ function.
Laminarization of turbulent pipe flow by fluid injection

The effects of fluid injection on the structure of an initially fully developed, low Reynolds number, turbulent pipe flow have been studied by means of a hot-film anemometer. Measurements were made of the axial turbulence intensity field and of the time-mean streamwise velocity distribution, both in the porous-walled pipe and in the solid-walled hydrodynamic development section. Oscilloscope traces showing the timewise pattern of the local velocity fluctuations were also monitored. The Reynolds number of the air flow at the inlet of the porous pipe was varied from 3090 to 6350, and the Reynolds number of the injected air ranged from 60 to 160. Near the tube wall, the initial effect of injection is a significant reduction of the axial turbulence level and an increase in the thickness of the viscous and buffer layers. The degree by which turbulence is reduced in this region is more or less proportional to the ratio of the injection to entrance Reynolds numbers. In the core region of the flow, which is centred about the tube axis, there is also an initial reduction in the magnitude of the axial component of turbulence which is thought to be due to injection-induced acceleration of the flow. There is also an annular region, which separates the wall and core regions, in which the turbulence intensity initially increases. In the downstream portion of the porous tube the entire flow undergoes a re-transition to fully developed turbulence.
Effects of combined nitrogen and phosphorus application on protein fractions and nonstructural carbohydrate of alfalfa

Nitrogen (N) and phosphorus (P) fertilization significantly affect alfalfa production and chemical composition; however, the effect of combined N and P application on protein fractions and the nonstructural carbohydrate content of alfalfa is not fully understood. This two-year study investigated the effects of N and P fertilization on the protein fractions, nonstructural carbohydrates (NSC), and alfalfa hay yield. Field experiments were carried out using two nitrogen application rates (N60, 60 and N120, 120 kg N ha − 1) and four phosphorus application rates (P0, 0; P50, 50; P100, 100; and P150, 150 kg P ha − 1), total 8 treatment (N60P0, N60P50, N60P100, N60P150, N120P0, N120P50, N120P100 and N120P150). Alfalfa seeds were sown in the spring of 2019, uniformly managed for alfalfa establishment, and tested in the spring of 2021–2022. Results indicated that P fertilization significantly increased the hay yield (3.07–13.43% ranges), crude protein (6.79–9.54%), non-protein nitrogen of crude protein (fraction A) (4.09–6.40%), and NSC content (11.00–19.40%) of alfalfa under the same treatment of N application (p < 0.05), whereas non-degradable protein (fraction C) decreased significantly (6.85–13.30%, p < 0.05). Moreover, increasing N application resulted in a linear increase the content of non-protein N (NPN) (4.56–14.09%), soluble protein (SOLP) (3.48–9.70%), and neutral detergent-insoluble protein (NDIP) (2.75–5.89%) (p < 0.05), whereas acid detergent-insoluble protein (ADIP) content was significantly decreased (0.56–5.06%, p < 0.05). The regression equations for nitrogen and phosphorus application indicated a quadratic relationship between yield and forage nutritive values. Meanwhile, the comprehensive evaluation scores of NSC, nitrogen distribution, protein fractions, and hay yield by principal component analysis (PCA) revealed that the N120P100 treatment had the highest score. Overall, 120 kg N ha − 1 coupled with 100 kg P ha − 1 (N120P100) promoted the growth and development of perennial alfalfa, increased soluble nitrogen compounds and total carbohydrate content, and reduced protein degradation, thus improving the alfalfa hay yield and nutritional quality.
100 Gb/s optical discrete multi-tone transceivers for intra- and inter-datacenter networks

Discrete multi-tone (DMT) technology is an attractive modulation technology for short-reach application due to its high spectral efficiency and simple configuration. In this paper, we first explain the features of DMT technology then discuss the impact of fiber dispersion and chirp on the frequency responses of the DMT signal and the importance in the relationship between chirp and the optical transmission band. Next, we explain our experiments of 100-Gb/s DMT transmission of 10 km in the O-band using directly modulated lasers for low-cost application. In an inter-datacenter network of more than several tens of kilometers, fiber dispersion mainly limits system performance. We also discuss our experiment of 100-Gb/s DMT transmission up to 100 km in the C-band without a dispersion compensator by using vestigial sideband spectrum shaping and nonlinear compensation.
Development and external validation of a prognosis model to predict outcomes after curative resection of early-stage intrahepatic cholangiocarcinoma

Background Early-stage intrahepatic cholangiocarcinoma (ESICC) with curative resection and lymph node-negative still has the risk of poor prognosis, and there lacks prognosis-assessing tools for these patients. The objective of this study was to develop a prognosis model to predict outcomes and identify risk stratification for ESICC after resection. Methods Totally 263 patients with ESICC after hepatectomy from January 2012 to January 2022 were analyzed. Clinicopathological factors were selected using multivariable Cox regression analysis and a prognosis model was developed. The performance of the model was evaluated by concordance index (C-index), calibration plots, decision curves analysis (DCA), and net reclassification index (NRI). Kaplan-Meier curves were analyzed for risk stratification of overall survival (OS) and recurrence-free survival (RFS) based on the prognosis model. Results The clinicopathological features that were independently associated with OS of ESICC included carbohydrate antigen19-9, carcinoembryonic antigen, tumor size, tumor differentiation, and T stage. The prognosis model based on these prognostic factors demonstrated excellent discriminatory performance in both derivation cohort (C-index, 0.71) and external validation cohort (C-index, 0.78), which outperformed the TNM staging system (C-index, 0.59) and individual prognostic factors (all C-index < 0.7). Calibration plots, DCA and NRI also showed superior predictive performance. According to the risk for survival, the model stratified patients into low risk (median OS, 66.6 months; median RFS, 24.3 months) and high risk (median OS, 24.0 months; median RFS, 6.4 months) (P < 0.001). Conclusions Our prognosis model can robustly predict the outcomes of ESICC after curative resection and provide precise evaluation on prognosis risk, facilitating clinicians to develop individualized postoperative treatment options.
Fer and FerT: A New Regulatory Link between Sperm and Cancer Cells

Fer and its sperm and cancer specific variant, FerT, are non-receptor tyrosine kinases which play roles in cancer progression and metastasis. Recent studies have shed light on the regulatory role of these kinases in ensuring proper sperm function. Comparison of the regulatory cascades in which Fer and FerT are engaged in sperm and cancer cells presents an interesting picture, in which similar regulatory interactions of these enzymes are integrated in a similar or different regulatory context in the two cell types. These diverse compositions extend from the involvement of Fer in modulation of actin cytoskeleton integrity and function, to the unique regulatory interactions of Fer with PARP-1 and the PP1 phosphatase. Furthermore, recent findings link the metabolic regulatory roles of Fer and FerT in sperm and cancer cells. In the current review, we discuss the above detailed aspects, which portray Fer and FerT as new regulatory links between sperm and malignant cells. This perspective view can endow us with new analytical and research tools that will deepen our understanding of the regulatory trajectories and networks that govern these two multi-layered systems.
Analysis of cumulative outcomes and influencing factors of patients with discrepancies between age and AMH levels in the early follicular phase prolonged protocol

Objective To explore the cumulative outcomes and influencing factors of patients with discrepancies between age and Anti-Müllerian hormone (AMH) levels in the early follicular phase prolonged protocol. Methods A total of 1282 cycles of in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) assisted pregnancy with the early follicular phase prolonged protocol in the Reproductive Medicine Center of the Third Affiliated Hospital of Zhengzhou University from September 2015 to December 2020 were retrospectively analyzed. They were divided into the young low-AMH group (n=1076) and the older high-AMH group (n=206). The primary outcomes included cumulative clinical pregnancy rate (CCPR) and cumulative live birth rate (CLBR). Secondary outcomes included the number of oocytes retrieved, number of available embryos, clinical pregnancy rate (CPR), live birth rate (LBR), miscarriage rate (MR), pregnancy complications, and neonatal outcomes. Results The CPR (68.7% vs. 59.4%) and the LBR (60.7% vs. 43.1%) in the young low-AMH group were higher than those in the older high-AMH group. In contrast, the number of oocytes retrieved (11 vs. 17), number of available embryos (5 vs. 8), and MR (10.6% vs. 18.3%) in the young low-AMH group were lower. There was no significant difference between the two groups in the CCPR, CLBR, pregnancy complications, and neonatal outcomes. Logistic regression analysis showed that infertility duration, basal follicle-stimulating hormone (FSH), and antral follicle count (AFC) correlated with CCPR, while maternal age, type of infertility, basal FSH, AFC, and infertility duration correlated with CLBR. The area under the receiver operating characteristic curves (ROC) curve for the combined model of infertility duration, AFC, and basal FSH to predict cumulative pregnancy was 0.629 (95%CI:0.592-0.666), while the combined model of maternal age, AFC, basal FSH, infertility duration, and type of infertility to predict cumulative live birth was 0.649 (95%CI:0.615-0.682). Conclusion Although AMH levels are low by contrast, young patients have a favorable outcome after IVF/ICSI. In patients with discrepancies between age and AMH levels in the early follicular phase prolonged protocol, maternal age correlates better with cumulative live birth. The model that combines maternal age and other factors can help predict cumulative live birth, but its value is limited.
Bone Cement and Its Anesthetic Complications: A Narrative Review

The concept of bone cement implantation syndrome (BCIS) is not yet fully understood. In patients undergoing cemented hip arthroplasty, it is a significant factor in intraoperative mortality and morbidity. It may also manifest in a milder form postoperatively, resulting in hypoxia and confusion. In the older population, hip replacement surgery is becoming more prevalent. The risks of elderly patients suffering BCIS may be increased due to co-existing conditions. In this article, we present a narrative review of BCIS including its definition, incidence, risk factors, etiology, pathophysiology, clinical features, prevention, and management, all from an anesthetic point of view.