Miracle-dz/UniFAR-FTUs huggingface dataset:
Low BACH2 Expression Predicts Adverse Outcome in Chronic Lymphocytic Leukaemia

Simple Summary Chronic lymphocytic leukaemia (CLL) is the most frequent type of leukaemia with a highly variable presentation, clinical course, and outcome. The overall aim of our study was to determine the clinical and functional significance of two B-cell regulators, BACH2 and BCL6, in CLL. The results showed that CLL patients expressing low levels of BACH2 and BCL6 RNA had a shorter overall survival (OS). Their low RNA expression was associated with a shorter overall survival of immunoglobulin heavy chain variable region-mutated (IGHV-M) CLL patients, as well as those with 11q and 13q deletions. Further, co-immunoprecipitation and mass spectrometry studies from MEC-1 CLL cells showed no direct interaction between BACH2 and BCL6, but shared protein networks that are involved in ubiquitination mediated B-cell receptor functions, nucleic acid metabolism, protein degradation, and homeostasis in CLL biology. Taken together, this study reports BACH2 as a potential prognosticator and indicates the protein networks influenced by BCL6 and BACH2 in CLL. Abstract Chronic lymphocytic leukaemia (CLL) is a heterogeneous disease with a highly variable clinical outcome. There are well-established CLL prognostic biomarkers that have transformed treatment and improved the understanding of CLL biology. Here, we have studied the clinical significance of two crucial B cell regulators, BACH2 (BTB and CNC homology 1, basic leucine zipper transcription factor 2) and BCL6 (B-cell CLL/lymphoma 6), in a cohort of 102 CLL patients and determined the protein interaction networks that they participate in using MEC-1 CLL cells. We observed that CLL patients expressing low levels of BCL6 and BACH2 RNA had significantly shorter overall survival (OS) than high BCL6- and BACH2-expressing cases. Notably, their low expression specifically decreased the OS of immunoglobulin heavy chain variable region-mutated (IGHV-M) CLL patients, as well as those with 11q and 13q deletions. Similar to the RNA data, a low BACH2 protein expression was associated with a significantly shorter OS than a high expression. There was no direct interaction observed between BACH2 and BCL6 in MEC-1 CLL cells, but they shared protein networks that included fifty different proteins. Interestingly, a prognostic index (PI) model that we generated, using integrative risk score values of BACH2 RNA expression, age, and 17p deletion status, predicted patient outcomes in our cohort. Taken together, these data have shown for the first time a possible prognostic role for BACH2 in CLL and have revealed protein interaction networks shared by BCL6 and BACH2, indicating a significant role for BACH2 and BCL6 in key cellular processes, including ubiquitination mediated B-cell receptor functions, nucleic acid metabolism, protein degradation, and homeostasis in CLL biology.
Delivering affordable housing through the planning system in urban renewal contexts: converging government roles in Queensland, South Australia and New South Wales

This paper outlines the current Australian policy environment for delivering affordable housing in urban renewal contexts. An increasing shift towards infill development, coupled with a decreasing provision of government-owned social housing, is placing severe pressure on housing affordability. The cumulative effect is to create the need for governments to intervene on urban renewal projects to ensure that affordable housing options are delivered as a part of any new development. Three different approaches to planning for affordable housing in three states are examined: the former Urban Land Development Authority in Queensland, the 15% inclusionary zoning requirement in South Australia and the Affordable Rental Housing State Environmental Planning Policy in New South Wales. Despite significant differences between these approaches, a number of potential roles emerge for government to support delivery of affordable housing by market and not-for-profit housing providers, without adversely affecting development viability. These roles are as the land facilitator, educator, risk taker, subsidiser and long-term planner. Given that one aim of current policy directions is to reduce the role of government in delivering housing and urban growth, the paper concludes by considering the extent to which the approaches across the three states studied can be considered successful.
Optimal Design of Resource Discovery-Allocation- Transmission-Offloading Strategy in Mobile Edge Computing

Mobile Edge Computing (MEC) is a key technology of IoTs and 5G networks and presents many challenges (such as resource discovery, resource allocation, computation offloading and transmission power design) that need to be addressed. Previous works studying on improving the performance of MEC system may only optimize these issues separately or just jointly optimized part of them. In this paper, we propose a Discovery-Allocation-Transmission-Offloading (DATO) strategy by taking all these aspects into consideration with discovery order to minimize energy consumption. Discovery strategy indicates when to suspend edge node (EN) discovery and perform computation offloading. Transmission strategy specifies the optimal power used to transmit the data. The offloading strategy tells the portion of data offloaded to the EN for execution. The discovery order demonstrates the sequence of EN searching. This problem is formulated as a stochastic sequential decision-making problem and Dynamic Programming (DP) is used to achieve the optimal scheme. Numerical results show the effectiveness of our proposed strategy.
Analysis and implementation of a zero voltage switching bi-forward converter

The system analysis and the circuit implementation of a zero voltage switching (ZVS) bi-forward converter is presented here. Two forward converters are adopted in the circuit with the active clamp technique to achieve interleaved PWM operation and load current sharing. Only two switches are used in the proposed converter instead of the four switches in the conventional parallel ZVS converter. Thus, the circuit components and conduction losses are reduced in the proposed converter. In the proposed circuit, the PWM signals of two switches are complementary to each other with a small delay time in order to realise the ZVS turn-on of the switches at the transition interval. Thus, the switching losses and thermal stresses of semiconductors are reduced since the interleaved PWM scheme is used to control two forward converters such that the output ripple currents are partially cancelled out. The sizes of the output chokes and capacitor are reduced. Experiments based on a 300 W prototype are provided to verify the theoretical analysis and the effectiveness of the proposed converter.
The Use of the Fourier-Bessel Series in Calculating Error Probabilities for Digital Communication Systems

Using the theory of spherical symmetric random vectors one can find an expression for the error probability of a wide variety of digital communications systems. These expressions, however, are in the form of Bessel integrals which are usually difficult to solve. In this paper we show how the Fourier-Bessel series can be used to solve the integrals numerically. The calculation error is found to depend on two series parameters which can be manipulated to make the error arbitrarily small. Two examples are used to show the utility of the technique. In the first the probability of error for a CPSK communications system operating in Gaussian noise and cochannel interference is found. In the second the error performance for a multilevel ASK communications system operating in the same corrupting environment is determined. The Fourier-Bessel series technique is a valuable practical tool for solving these and other signal detection problems.
Numerical calculation of a Tchebyscheff tapered balun transformer

The CAD of a Tchebyscheff tapered balun transformer which will function over frequency bandwidths as great as 100:1 is presented. The balun impedance is tapered so that the input reflection coefficient follows a Tchebyscheff response in the pass band. But some functions in the theory are not expressible in closed form except for special values of the parameters. So the values of the functions are obtained from the tabulation. As a result, the design of the balun can not get more accurate values of the functions. With the numerical calculation, we can get the exactly values in a few seconds.
Self-Excited Oscillations of a Circular Disk Rotating in Air

Self-excited oscillations are often observed in a circular disk when it is rotated in air. Theoretical as well as experimental studies are conducted on these oscillations. As a preparatory study, free vibrations of the disk are discussed theoretically without taking into account the effect of air. Then, utilizing the results of this preparatory study, and taking into account the effect of air, free vibrations of the disk are studied. It is shown that self-excited oscillations can occur at a rotating speed higher than a certain value in the form of abackward traveling wave. Experiments confirm the theoretical analysis.
Hubungan antara depresi, kecemasan dan stress dengan motivasi berprestasi atlet putri selama pandemi covid 19

The COVID-19 pandemic can certainly affect the performance and psychological condition of athletes. The purpose of this study was to describe the relationship between depression anxiety and stress on achievement motivation in female athletes during the pandemic. This study uses a quantitative approach research method. The sample used was female athletes amounting to 65 people. Data collection techniques using online questionnaires via google form. The questionnaire used in this study was the Depression Anxiety Stress Scale 42 (DASS 42) from Lovibond and Lovibond (1995) and the achievement motivation questionnaire. Data analysis was carried out using the Kendal tau correlation technique with the help of the SPSS 21 program. The results showed a negative correlation between depression and motivation of (-0.65);a significance value of 0.000 (p<0.05) between anxiety and motivation of (-0.57);a significance value of 0.000 (p<0.05) between stress and motivation of (-0.51);significance value 0.000 (p<0.05). The conclusion is that the higher the level of depression anxiety and stress the lower the athlete’s achievement motivation the relationship between depression and achievement motivation is in the strong category anxiety and achievement motivation is in the medium category and between stress and achievement motivation is in the medium category
Climate-Energy Policies, Heat Provision, and Urban Planning: A Renewal of Interest in District Heating in France: Insights from National and Local Levels

Abstract How do climate and energy objectives influence the renewal of the role of network infrastructures in urban planning and the running of urban systems? The example of the revival of interest in district heating networks provides a few possible answers to this question, which is central to the understanding and characterization of the conditions for carrying out the urban energy transition. In this paper, we study this example by analyzing recent changes in French regulations and the process of creating an intercommunal energy-related competence in the Lyon metropolitan area. Emphasis is placed on the institutional and political conditions surrounding a change in governance as well as the underlying justifications in the reconsideration of an existing infrastructure in view of new energy, climate, and social challenges within a specific urban context. Our study has been carried out in reference to several discussions on urban planning and on institutional, political, and spatial factors that shape urban infrastructure regimes.
Polarization mode dispersion characterization of single-mode optical fiber using backscattering technique

This paper presents a completely new method able to characterize polarization mode dispersion (PMD) properties of randomly birefringent single-mode fibers, using polarization sensitive backscattering technique. We show analytical relationships between evolution of polarization state of backscattered signal with respect to state of polarization of forward one. Our technique allows one to measure differential group delay, beat length, and correlation length at the same time over long single-mode fibers using only one fiber end. Experimental data fit very well with numerical results, confirming the capability of our technique for fast routine characterization of PMD during cabling, before and after installation.
Review of Small-Signal Converter-Driven Stability Issues in Power Systems

New grid devices based on power electronics technologies are increasingly emerging and introduce two new types of stability issues into power systems, which are different from traditional power system stability phenomena and not well understood from a system perspective. This paper intends to provide the state of the art on this topic with a thorough and detailed review of the converter-driven stability issues in partial or all power electronics-based grids. The underlying and fundamental mechanisms of the converter-driven stability issues are uncovered through different types of root causes, including converter controls, grid strength, loads, and converter operating points. Furthermore, a six-inverter two-area meshed system is constructed as a representative test case to demonstrate these unstable phenomena. Finally, the challenges to cope with the converter-driven stability issues in future power electronics-based grids are identified to elucidate new research trends.
Design refresh planning models for managing obsolescence

Fast moving technologies cause high-tech components to have shortened life cycles, rendering them quickly obsolete. Obsolescence is a significant problem for systems whose operational and support life is much longer than the procurement lifetimes of their constituent components. Long field-life systems such as aircraft, ships, and other systems require many updates of components and technology over their life to remain in manufacture and supportable. Design refresh planning is a strategic way of managing obsolescence. In this article, efficient mathematical models based on Integer Programming for design refresh planning are developed to determine the plan that minimizes the total obsolescence management costs. Decisions are made on when to execute design refreshes (dates) and what obsolete/non-obsolete system components should be replaced at a specific design refresh. Data uncertainty is also considered and obsolescence dates of the components are assumed to follow specific probability distributions. With this approach, different scenarios of executing design refreshes and the probabilities of adopting these scenarios can be determined. The final optimal cost becomes an expected value. An example of an electronic engine control unit is included for demonstration of the developed models.
Herramientas digitales en tiempos de covid-19: percepción de docentes de educación superior en México

Este estudio tuvo como objetivo medir la percepción del uso de herramientas digitales para gestionar cursos y videoconferencias utilizadas por docentes de tres instituciones de educación superior en México a raíz de la pandemia de la enfermedad por coronavirus de 2019 (covid-19). Mediante un estudio de corte cuantitativo, descriptivo y transversal, se determinó la utilidad y facilidad de uso percibida de las tecnologías de la información y la comunicación (TIC) utilizadas por las universidades mexicanas para transitar de la modalidad presencial a la modalidad online. Para ello, se aplicó un instrumento basado en el modelo de aceptación tecnológica a una muestra total de 192 docentes de tres universidades: Universidad Autónoma de Chiapas, Universidad Autónoma de Baja California Sur y Universidad de Sonora. Como resultados principales, se observó que el sistema de gestión de aprendizaje con valoración de aceptación alta en las tres instituciones analizadas fue Moodle; mientras que la herramienta para videoconferencias Zoom fue la que obtuvo mayor frecuencia con valoración alta.
Polycyclic nitrogen heterocycles as potential thymidine phosphorylase inhibitors: synthesis, biological evaluation, and molecular docking study

Abstract New polycyclic heterocycles were synthesised and evaluated as potential inhibitors of thymidine phosphorylase (TP). Inspired by the pharmacophoric pyrimidinedione core of the natural substrate, four series have been designed in order to interact with large empty pockets of the active site: pyrimidoquinoline-2,4-diones (series A), pyrimidinedione linked to a pyrroloquinoline-1,3-diones (series B and C), the polycyclic heterocycle has been replaced by a pyrimidopyridopyrrolidinetetraone (series D). In each series, the tricyclic nitrogen heterocyclic moiety has been synthesised by a one-pot multicomponent reaction. Compared to 7-DX used as control, 2d, 2l, 2p (series A), 28a (series D), and the open intermediate 30 showed modest to good activities. A kinetic study confirmed that the most active compounds 2d, 2p are competitive inhibitors. Molecular docking analysis confirmed the interaction of these new compounds at the active binding site of TP and highlighted a plausible specific interaction in a pocket that had not yet been explored.
Magamp application and limitation for multiwinding flyback converter

A new magamp technique for multiwinding flyback converters is proposed. Ideal operating principle and analysis are presented. The practical circuit operation is limited due to the nonideal component characteristics. An analytical model for studying the phenomenon is provided. Based on the model, the mechanism of the boundary condition that causes the converter to be out of regulation is explored. Experimental verifications on a 20 W two-output flyback converter are conducted. They illustrate the effectiveness of the proposed magamp approach and the accuracy of the presented analytical model.
Time Between Viral Loads for People With HIV During the COVID-19 Pandemic

Supplemental Digital Content is Available in the Text. Background: During the COVID-19 pandemic, patients experienced significant care disruptions, including laboratory monitoring. We investigated changes in the time between viral load (VL) checks for people with HIV (PWH) associated with the pandemic. Setting and Methods: This was an observational analysis of VLs of PWH in routine care at a large subspecialty clinic. At pandemic onset, the clinic temporarily closed its onsite laboratory. The exposure was time period (time varying): prepandemic (January 1, 2019–March 15, 2020); pandemic laboratory closed (March 16–July 12, 2020); and pandemic laboratory open (July 13–December 31, 2020). We estimated time from an index VL to a subsequent VL, stratified by whether the index VL was suppressed (≤200 copies/mL). We also calculated cumulative incidence of a nonsuppressed VL following a suppressed index VL, and of resuppression following a loss of viral suppression. Results: Compared with prepandemic, hazard ratios for next VL check were 0.34 (95% CI: 0.30 to 0.37, laboratory-closed) and 0.73 (CI: 0.68 to 0.78, laboratory-open) for suppressed patients, and 0.56 (CI: 0.42 to 0.79, laboratory-closed) and 0.92 (95% CI: 0.76 to 1.10, laboratory-open) for nonsuppressed patients. The 12-month cumulative incidence of loss of suppression was the same in the pandemic laboratory-open (4%) and prepandemic (4%) period. The hazard of resuppression following the loss of suppression was lower during the pandemic laboratory-open versus the prepandemic period (hazard ratio: 0.68, 95% CI: 0.50 to 0.92). Conclusions: Early pandemic restrictions and laboratory closure significantly delayed VL monitoring. Once the laboratory reopened, nonsuppressed patients resumed normal monitoring. Suppressed patients still had a delay but no significant loss of suppression.
VHR imagery change detection using UNet based on fusion of residual polymer and attention mechanism

VHR imagery change detection is one of research hotspots and difficulties in the field of remote sensing. However, the traditional remote sensing image change detection method is a waste of time and energy and low efficiency. In recent years, deep learning approaches in remote sensing image change detection verified feasible and save time to improve efficiency. A UNet change detection method based on aggregation residuals and attention mechanism is proposed, using prior knowledge of deep learning. The UNet model is used as the basic model, and the aggregation residual module is introduced in the up-down sampling stage, which can fully extract the feature information of the image. The weight of each component in the feature graph can be adjusted by adding attention module in the jump connection layer. In the process of experiment based on the model parameters are reasonable and effective set of data sets to Longnan remote sensing image change detection, and the experimental results showing that compared with the traditional deep learning semantic segmentation method, this article methods F1 value of 0.873, the generated change detection figure closer to label figure, higher accuracy, shorter.
Mercado de control corporativo: dos modelos a examen. España vs Irlanda

En el presente trabajo se realiza un estudio comparativo de las operaciones de fusión y adquisición sobre empresas cotizadas en dos países, España e Irlanda, pertenecientes a sendos modelos de gobierno corporativo existentes en Europa. El análisis realizado a partir de la información correspondiente a las operaciones anunciadas durante el período 1993-2016, revela una mayor actividad e internacionalización del mercado de control irlandés, una mayor importancia de las tomas de control minoritario en España, mayores primas pagadas a los accionistas en Irlanda y diferencias entre el perfil de las empresas adquiridas en ambos países. Estas diferencias no parecen haberse visto suavizadas en el tiempo como consecuencia del mayor proceso de integración económica y armonización legislativa en la Unión Europea.
Variable-speed switched reluctance motors

The paper explores the theory and potential of a family of doubly salient electronically-switched reluctance motors. It is demonstrated that the machine provides the basis for fully-controllable variable-speed systems, which are shown to be superior to conventional systems in many respects. The motor retains all the advantages normally associated with induction motors and brings significant economy in the drive electronics. The basic modes of operation, analysis, design considerations and experimental results from a range of prototype motors up to 15 kW at 750 rev/min are described. The most recent prototype has achieved a continuous rating which is 1.4 times that of the equivalent induction motor.
Energetic Analyses of the Combined Heat and Power (CHP) System

This study deals with the energetic analysis of a combined heat and power (CHP) system installed in Eskisehir City of Turkey. The mass and energy balance relations are derived and applied to the components of CHP system and overall CHP system. The performance characteristics of this CHP system are evaluated in terms of energetic aspects. Considering total output energy, the total energy efficiencies (electrical and thermal) of gas turbine cycle, heat recovery steam generator(HRSG), steam cycle and CHP system are 95.3 %, 83.56 %, 76.7 % and 79.3 %, respectively. Based on total useful energy output (excepting the stack gas, waste boiler loss, condenser line, medium pressure steam collector energies), the total useful energy efficiencies of gas turbine cycle, HRSG, steam cycle and CHP system are 82.3 %, 65.2 %, 18.5 % and 40.02 %, respectively.