Miracle-dz/UniFAR-FTUs huggingface dataset:
Fault Diagnosis for Bearing Based on 1DCNN and LSTM

Condition monitoring and fault diagnosis of the bearing are essential for the smooth operation of rotating machinery. In this paper, an end-to-end intelligent fault diagnosis method for bearing combining one-dimensional convolutional neural network with long short-term memory network (1DCNN-LSTM) is proposed for the deficiencies of existing fault diagnosis methods. First, the proposed method takes one-dimensional fault data directly as input. Second, one-dimensional convolutional neural network (1DCNN) is used for self-adaptively extracting robust features from the original bearing signal, and more features are extracted while ensuring the validity and saliency of the extracted features by combining maximum pooling and average pooling layers to downsample features. Then, long short-term memory network (LSTM) is used to learn the temporal dependencies among features. At last, fault identification is achieved. 1DCNN-LSTM does not require any manual feature extraction, and the errors caused by reliance on expert experience and incomplete information in traditional feature extraction methods are avoided. The results show that the proposed classifier with good generalization performance not only diagnoses the category of fault quickly and accurately under different load conditions but also achieves an average fault identification accuracy of 99.95%. For its powerful learning abilities, this method can also be applied to the bearing fault diagnosis of rotating machinery in many fields.
Pharmacokinetics and Toxicokinetics of Artemisinin-Hydroxychloroquine Sulfate Tablets in Rats and Dogs

Artemisinin-hydroxychloroquine sulfate tablets (AH) are relatively inexpensive and a novel combination therapy for the treatment of all forms of malaria, especially aminoquinine drug-resistant strains of P. falciparum. Our aim was to assess the pharmacokinetics (PK) and toxicokinetics (TK) of AH following oral administration in Sprague Dawley rats and Beagle dogs by using the liquid chromatography tandem mass spectrometry methods (LC-MS/MS). The PK studies were carried out in eighteen rats at three doses and six dogs at three rounds of three doses after a single oral administration of AH. The TK studies in rats and dogs were accompanied by the 14-day repeated dosing studies. The PK results revealed that artemisinin was absorbed and cleared rapidly in rats with obvious gender difference and interindividual variability, and the systemic exposure with regard to AUC was positively correlated with the dosage in female rats. However, the kinetics parameters of artemisinin in dogs were not obtained because the plasma concentration was undetectable. The absorption and elimination of hydroxychloroquine in dogs and rats were relatively slow, and no gender difference was observed. The AUC of hydroxychloroquine showed a linear correlation with the dosage, but Cmax varied significantly among individuals. After 14-day repeated oral administration of AH, hydroxychloroquine shows an increase in systemic exposure and accumulation in rats and dogs, whereas the AUC and Cmax of artemisinin remarkably decreased in female rats due to its autoinduction metabolism. The TK results were basically consistent with the dose- and time-dependent toxic reaction in 14-day repeated dosing studies of AH in rats and dogs. The information from our studies could be helpful for further pharmacological and toxicological research and clinical application of AH.
The Potential of Vouacapanes from Pterodon emarginatus Vogel Against COVID-19 Cytokine Storm

Purpose: The emergence of the COVID-19 pandemic has led to the search for potential therapeutic responses for various aspects of this disease. Fruits of Pterodon emarginatus Vogel (Fabaceae), sucupira, have been used in Brazilian traditional medicine because of their anti-inflammatory properties, which have been proven in vivo, in vitro, and in silico. Therefore, the aim of this work is to evaluate P. emarginatus oleoresin and isolated diterpenes by in vitro anti-inflammatory models. Methods: In this study, the mechanisms underlying the anti-inflammatory activity of P. emarginatus oleoresin and vouacapanes 6α,19β-diacetoxy-7β,14β-dihydroxyvouacapan (V1), 6α-acetoxy-7β,14β-dihydroxyvouacapan (V2), and methyl 6α-acetoxy-7β-hydroxyvouacapan-17β-oate (V3) were investigated in HaCaT cells. Results: Oleoresin, V2, and V3 inhibited phospholipase A2 (30.78%, 24.96%, and 77.64%, respectively). Both vouacapanes also inhibited the expression of COX-2 (28.3% and 33.17%, respectively). The production of interleukin 6 (IL-6) was inhibited by oleoresin by 35.47%. However, oleoresin did not interfere with Nrf-2 expression or IL-8 production. Conclusion: The results support the ethnomedicinal use of P. emarginatus oleoresin as an anti-inflammatory herbal medicine, and also highlight P. emarginatus oleoresin and isolated vouacapanes as an attractive therapeutic approach for COVID-19 through the reduction or chronological control of the inflammatory mediators IL-6, cyclooxygenase-2 (COX-2), phospholipase A2, and INF-y (indirectly) during the SARS-CoV-2 infection process.
OP-MOLB180226 472..486

The ubiquity of plasmids in all prokaryotic phyla and habitats and their ability to transfer between cells marks them as prominent constituents of prokaryotic genomes. Many plasmids are found in their host cell in multiple copies. This leads to an increased mutational supply of plasmid-encoded genes and genetically heterogeneous plasmid genomes. Nonetheless, the segregation of plasmid copies into daughter cells during cell division is considered to occur in the absence of selection on the plasmid alleles. We investigate the implications of random genetic drift of multicopy plasmids during cell division—termed here “segregational drift”—to plasmid evolution. Performing experimental evolution of lowand high-copy non-mobile plasmids in Escherichia coli, we find that the evolutionary rate of multicopy plasmids does not reflect the increased mutational supply expected according to their copy number. In addition, simulated evolution of multicopy plasmid alleles demonstrates that segregational drift leads to increased loss frequency and extended fixation time of plasmid mutations in comparison to haploid chromosomes. Furthermore, an examination of the experimentally evolved hosts reveals a significant impact of the plasmid type on the host chromosome evolution. Our study demonstrates that segregational drift of multicopy plasmids interferes with the retention and fixation of novel plasmid variants. Depending on the selection pressure on newly emerging variants, plasmid genomes may evolve slower than haploid chromosomes, regardless of their higher mutational supply. We suggest that plasmid copy number is an important determinant of plasmid evolvability due to the manifestation of segregational drift.
Exploration of Cross-Modal Text Generation Methods in Smart Justice

With the development of modern science and technology, information technology has brought great changes to many fields. Smart justice has become one of the increasing areas that people are paying more attention to. For example, large and small cases occur every day, and the legal library is continuously updated. Therefore, a large number of documents and evidence collection archives will bring tremendous pressure on the judiciary. The text generation technology can automatically present the results extracted from these redundant legal data and express the results of the analysis in natural language. It facilitates the business for huge amounts of legal data effectively, which relieves the work pressure of the judicial department. However, the text generation algorithms have not been promoted in justice. Therefore, this paper focuses on what benefits text generation can produce in law and how to apply text generation technology in legal field. The survey provides a comprehensive overview on text generation firstly, through summarizing the existing methods, that is, text to text, data to text, and visual to text. Then, we examine the process of the practical application of text generation in law. Furthermore, this paper puts forward the challenges and possible solutions to the judicial text generation, which provides pointers on future work.
The Effect of Educational Intervention on Rational Prescribing in Public Health Facilities in Selected Local Government Areas of Rivers State: An Interventional Study

Background: Despite progress made so far in identifying intervention models to improve drug use, irrational use of drugs has remained a serious global health problem. The study intends to determine the effectiveness of an educational intervention on rational prescribing among prescribers in selected local government areas of Rivers State. Methods: This was a quasi-experimental study that measured the effect of educational intervention on rational prescribing of drugs among prescribers in public health facilities in two selected Local Government Areas (LGA) of Rivers State: Ikwerre LGA (KELGA) which served as the control and Port Harcourt LGA (PHALGA) which served as the intervention by using cluster sampling with randomization. Paired data were analysed using McNemar’s Chi-square test and the paired t-test. The level of significance was set at P≤ 0.05. The EPI-INFO version 7.02 statistical software was used in the analysis. Results: Findings showed that the largest category of prescribers was nurse/midwives representing 48.61% and 44.4% in the intervention and control LGA respectively. There was an improvement in the knowledge and attitude of respondents in the facilities in the intervention LGA at one month and three months post-intervention (P<0.05). The average number of drugs per encounter (ANDPE), the percentage encounters with an antibiotic (PEA), the percentage encounters with an injection (PEI) were lower for the interventions group compared to the control (P<0.05). Percentage generic drug prescription (PGD) was higher in the intervention group compared to the control (P=0.001). Conclusion: Educational intervention was an effective and sustainable means of improving rational prescribing in the state. Update courses and continuing medical education on rational drug use should be held periodically for health care professionals by the State and National Primary Health Care Development Agency as well as other interested stakeholders.
Assessment of Growth and Fertility Hormones of Albino Rats Exposed to Quarry Dust at a Quarry Industry

Aim: Growth and fertility hormones of albino rats exposed to quarry dust were evaluated to determine if the inhaled quarry dust and heavy metals contained in it have any effect on the fertility and growth of the rats. Methods: Sixty (30 in each of wet and dry seasons) male albino rats were used in this study and were housed in six (6) sterilized plastic cages with five (5) rats in each cage at Ugwuele quarry industry Uturu. The control (group 1) was housed at a distance of 7.2km from the quarry site. Group 2 was housed at the administration block of the quarry industry while groups 3,4,5,6 were housed at the gate, plant house, drilling pit and crusher positions of the quarry industry respectively. Heavy metals; lead, chromium, cobalt, arsenic, zinc and cadmium from dust samples were analyzed with atomic absorption spectrophotometer while assay for hormones was also carried out using standard analytical methods. Results: All the analyzed heavy metals were present in the dust. Concentrations of heavy metals in the quarry dust were significantly higher (p<0.05) than the control and higher in the dry season than in the wet season. Concentrations of prolactin, follicle stimulating hormone (FSH), luteinizing hormone (LH) and growth hormone (GH) in the test samples were significantly lower (p<0.05) compared to the control while the concentrations of thyroid stimulating hormone (TSH) in the test samples were significantly higher (p<0.05) compared to the control. Results also show that the concentrations of prolactin, FSH, LH and GH were lower in the dry season than in the wet season whereas, the concentrations of TSH in the exposed rats were higher in the dry season than in the wet season. Conclusion: Growth rate and fertility of the albino rats may have been compromised by the exposure to the quarry dust, since the growth and fertility hormones were all reduced.
Atypical Mycobacterial Tenosynovitis in the Setting of Adalimumab Use

Tumor necrosis factor-alpha (TNF-α) inhibitors indicated in the management of psoriasis, rheumatoid arthritis, ulcerative colitis, Crohn’s disease, and other autoimmune diseases have been associated with the development of mycobacterial and other opportunistic infections. The majority of mycobacterial infections diagnosed in patients taking TNF-α inhibitors are secondary to Mycobacterium tuberculosis. Atypical mycobacteria have also been identified in this patient population, most commonly manifested by pulmonary or disseminated infections. Extra-pulmonary manifestations such as bone and joint infections are rare. We describe a case of atypical mycobacterial tenosynovitis in the setting of adalimumab use in a patient with psoriasis. This is a rarely reported complication that one should be aware of when prescribing these medications.
Measuring Efficiency in the Summer Olympic Games Disciplines: The Case of the Spanish Athletes

This paper estimates the technical efficiency of Olympic disciplines in which Spanish athletes participate, taking into account the results obtained in the last three Olympic Games. A stochastic production frontier model (normal-exponential), using two control variables linked to economic factors such as budget and sports scholarships, is estimated in order to obtain different Olympic sports’ efficiencies distinguished by gender, using data from 2005 to 2016. The results detect some differences among the considered disciplines. In all the cases, athletics, canoeing, cycling, swimming, and tennis, depending on the gender, reach better values. This paper’s novelty lies in the efficiency analysis carried out on the Olympic disciplines and athletes of a country and not on the country’s efficiency, which allows managers and stakeholders to decide about investments concerning disciplines and athletes.
The PCSK9 Involves in the Dyslipidemia of Ovariectomized Mice and Its Mechanism

Ovarian failure in postmenopausal female leads E2 to dramatic decrease which is an important reason of menopausal dyslipidemia. PCSK9 as a secretory lipid metabolic regulator plays a critical role in the cholesterol metabolism by negatively regulating LDLR in hepatocytes. Clinical data showed PCSK9 was elevated and positively correlated with LDL-C in the blood of postmenopausal women. However, the relationship between E2 and PCSK9 and the role of PCSK9 in postmenopausal dyslipidemia are still unclear. In this research, 10-week-old ovariectomized mice were fed for 4 weeks with normal diet or high-fat diet, then tested the lipid metabolism profiles and PCSK9 in the blood and the expression of LDLR and PCSK9 in the liver. On this basis, PCSK9-/- ovariectomized mice were used to further verify the effect of PCSK9 in dyslipidemia of ovariectomized mice. Finally, the ovariectomized mice with high-fat diet were subcutaneous injected respectively with E2 or PCSK9 inhibitor alone or both together for 2 weeks and were tested as previous experiment. The results showed PCSK9, TC and LDL-c all increased in the blood of in WT ovariectomized mice and their PCSK9 is positively correlated with LDL-c, while there were on obvious lipid metabolism disorder in the PCSK9−/− ovariectomized mice. PCSK9 inhibitor increased the LDLR on the liver and ameliorated the dyslipidemia in WT ovariectomized mice. It suggests that PCSK9 plays an important role in the dyslipidemia of ovariectomized mice, which provides a new strategy for clinical diagnosis and treatment of the dyslipidemia in post-menopause.
Analytical model of a T-core coil above a multi-layer conductor with hidden hole using the TREE method for nondestructive evaluation

Purpose In eddy current nondestructive testing, a probe with a ferrite core such as an E-core coil is usually used to detect and locate defects such as cracks and corrosion in conductive material. However, the E-core coil has some disadvantages, such as large volume and difficulty in the process of winding the coils. This paper aims to present a novel T-core probe and its analytical model used for evaluating hidden holes in a multi- layer conductor. Design/methodology/approach By using a cylindrical coordinate system, the solution domain is truncated in the radial direction. The magnetic vector potential of each region excited by a filamentary coil is derived, and the expansion coefficients of the solutions are obtained by matching the boundary and interface conditions between the regions. By using the truncated region eigenfunction expansion method, the final expression in closed form for the impedance of the multi-turn coil is worked out, and the impedance calculation is performed in Mathematica. For frequencies ranging from 100 Hz to 100 kHz, both the impedance changes of the T-core coil above the multi-layer conductor without a hidden hole and in the absence of the layered conductor were calculated, and the influence of a hidden hole in the multi-layer conducting structure on the impedance change was investigated. Findings The correctness of the analytical model of the T-core coil was verified by the finite element method and experiments. The proposed T-core coil has higher sensitivity than an air-core coil, and similar sensitivity and smaller size than an E-core coil. Originality/value A new T-core coil probe and its accurate theoretical model for defect evaluation of conductor were presented; probe and analytical model can be used in probe design, detection process simulation or can be directly used in defect evaluation of multi-layer conductor.
Numerical evaluation of finite length tubes effects in Stirling engines heaters

The performance of Stirling engines is directly related to the amount of energy that, in the form of heat, participates in the thermodynamic cycle. A peculiar characteristic of this type of engine is the closed circuit of the working fluid, implying a periodic admission and extraction, ideally involving the whole working fluid, of the heat exchanged during the cycle without any exchange of material with the external environment. Several correlations have been proposed in the literature to predict the heat exchange in the hot side heat exchangers, but most of them are based on nondimensional numbers, usually expressed in terms of an oscillatory Reynolds number and a non-dimensional length, that even if they take into account the amplitude and frequency of the oscillating flow inside the tube with respect to its diameter, do not include any dependency upon the length of the tube. Nevertheless, the length of the tube can have a great impact on the performance of a Stirling engine. The heater forms a significant part of the dead volume of the engine, making the optimization of the volume to surface ratio necessary. The friction losses increase by increasing the length of the tubes, determining a negative impact while the exchange surface increases. Even the Nusselt number in the inner side of the tubes changes along the length, achieving the largest values alternatively in the first portions of the tube lengths because of entrance effects (Graetz problem). The picture is made even more complex because of the special velocity profiles that develop in oscillating flows in tubes. One of the effects less investigated in previous studies, which we could call a “breathing effect”, regards the amount of working fluid that, in a real engine, can effectively travel from the hot side to the cold side, thus reaching the conditions of nominal heat exchange with the thermal source and sink of the cycle. An idealized configuration has been devised to investigate, using CFD simulations, these effects. Results reporting how the friction coefficient and the Nusselt number depend on the finite length of the tube will be illustrated.
Concept of the Social Design in Public Spaces Practice – cases of Berlin and Taipei

The study aims to compare two social design concepts that take place in Taipei and Berlin by the case study. The first case focus on the technology applied in the solution, the historical area located in Taipei, it used AR, chatbot, and web VR to let the users in-depth experience of the background story. On the other hand, Berlin’s case was done under design oriented, it follows user-center design to define the problem and focus on the user experience, finally comes up with a conceptual App, these cases we chose are both based on the concept of increasing the connectivity between people and regions. This study follows the process of action research, and the innovation model proposed by IDEO was used to analysis these two cases, it has three essential perspectives, “Feasibility”, “Desirability” and “Viability”. This research is currently in the process, but we expect the result could improve the practice of social design in public spaces, as the conclusion, we found out that it needs not only balance integration of technology and design content but also include a business field to make the service system more complete.
Quantifying the potential market for new contraceptive technologies: global projections of 2040 contraceptive needs and preferences

Background: Despite a wide range of contraceptive methods, unmet need persists. New contraceptive technologies (CTs) have the potential to improve uptake and continuation. CT development has a long-time horizon; products will be introduced into markets that look very different than today. Identifying viable investments requires an understanding of these future markets. For this work the 2040 potential contraceptive market is described utilizing seven market segments based on marital status, fertility preferences, and patterns of sexual activity outside of marriage. Methods: Market size estimates are developed by country for all countries in the world for a current market (2020) and a future market (2040). United Nation’s (UN) population projections of the number of women of reproductive age (WRA) form the basis of this work. WRA are then segmented into market segments based on marital status, fertility intentions, and patterns of sexual activity outside of marriage. Each segment is further subdivided by contraceptive use versus non-use. Segmentation draws from UN projections, household surveys, census data, and modeling techniques developed for this work. Results: The largest market increases will be seen in Africa; most notably among the segment of married women wanting no more children. By contrast, Asia will see declines across all three married segments, coupled with increases among sexually active unmarried segments. Levels of contraceptive use are projected to vary widely by segment, with differential patters across regions. Conclusions: This analysis projects the impact of demographic changes, evolving fertility preferences, shifts in sexual activity outside of marriage and increased utilization of contraceptives in shaping the contraceptive market of 2040. Results show that there is not one global market, but distinct markets that vary in size and shape across the world. This diversity suggests that a range of different new CTs could have potential for uptake.