Miracle-dz/UniFAR-FTUs huggingface dataset:
Spatial point pattern analysis of prehospital naloxone administrations

Objectives The increasing problem in the United States with opioid dependence and overdose, often fatal, is well-recognized. As naloxone has only one clinical use—the treatment of opioid overdose—its administration by EMS personnel can serve as a surveillance indicator for opioid overdose. This study uses specific locations of EMS calls, and methods of point pattern analysis, to detect overall spatial clustering among EMS naloxone administrations compared to EMS calls in general. Study Design A cross-sectional study of incident locations of EMS responses in a three-county EMS region in the United States. Methods Repeated random samples from the spatial distribution of all EMS calls were used, in a Monte Carlo simulation, to represent the background inhomogeneity of the population. Observed F, G, and inhomogeneous K and L functions from the spatial distribution of naloxone-involved calls were compared to their null sampling distributions obtained from the Monte Carlo simulation. Results Cases of naloxone administration demonstrated spatial clustering in the range of 0 to 5000 meters, and particularly around 2500 meters, beyond what could be attributable to the spatial heterogeneity of all EMS calls. Conclusions Efforts to understand the fundamental nature of opioid overdose as a spatial point process could yield innovative public health interventions to control the epidemic.
Hurricane Preparedness of Community-Dwelling Dementia Caregivers in South Florida

x Chapter 1: Introduction 1 Anthropological Contributions to the Study of Alzheimer’s and Disasters 2 Justification for Research 4 Overview of Chapters 5 Notes on Terminology 12 Chapter 2: Research Setting 14 History and Background: Hurricanes in Florida 15 Okeechobee Hurricane of 1928 18 Contemporary Hurricanes 21 Hurricane Andrew 21 Hurricane Charley 21 Hurricane Frances 22 Hurricane Ivan 22 Hurricane Jeanne 23 2005 Hurricane Season 24 Hurricane Dennis 24 Hurricane Katrina 24 Hurricane Wilma 25 Special Needs Shelters (SpNS) 26 Chapter 3: Literature Review of Alzheimer ’s disease and Caregiving 30 Part I: Alzheimer’s Disease and Related Dementias 32 Core Theoretical Concerns. 33 Time and Age 34 Social Construction of the Dementias 36 “Normal Aging” and Naming a Disease: A Bio-social Endeavor 37 Measuring Loss: Diagnosis, Testing, and Stages 42 Biomedical Processes 42 Diagnostic and Statistical Manual of Mental Disorders 43 The Three-Stage Alzheimer’s Disease Model 44 Seven Stage Dementia Models 47 Functional Assessment Staging (FAST) 49 Activities of Daily Living (ADLs) 52 Dementia and Risk. 54 Wandering and Becoming Lost 55 Mechanisms for Reducing Risks 57 ii Summary and Key Points AD and Related Dementias 58 Part II: Background and Literature Review: Caregiving for a Person with Dementia 59 Social Roles: Nature and Nurture 60 Who Provides Informal Care? 60 Motivations to Provide Care for PWD 63 Caregiving and Risk 65 Quality of Care 66 Home and Community-Based Care: Costs and Benefits 67 Caring and Disaster Planning 71 Summary and Key Points of Caregiving 72 Chapter 4: Literature Review Hurricane Vulnerability and Constructions of Risk 74 Disasters and Vulnerability 74 The Disaster Cycle 77 Mitigation 77 Disaster Preparedness 78 Pressure and Release Model 78 Local Emergency Management Plans 80 Measuring Destruction: The Saffir-Simpson Wind Scale 81 Theoretical Frameworks: Risk Society 81 Certainty in the Cone of Uncertainty 85 Summary of Disaster Literature 86 Chapter 5: A Theoretical Synthesis of Anthropology of Dementia and the Anthropology of Disasters 88 Anthropology of Policy 89 Health Policy and Critical Medical Anthropology 90 Anthropology of Disasters 93 Anthropology Disaster and the Aged 95 Anthropology of Disability and Disaster 97 Critique of Vulnerability 99 Anthropology of Dementia 101 Biological Death 103 Living Death 103 Relational Death and the Politics of Recognition 104 Biosocial death 107 Exploring and Developing an Explanatory Model of “Risk Fatigue” 109 Hurricane “Amnesia” and Public Health Implications 114 Summary and Key Points 116 Chapter 6: Methodology 117 Partnering Organization 118 Mixed Methods 121 Ethical Considerations 123
Integrated modeling and monitoring of the medieval bridge azzone visconti

This paper presents the modeling and monitoring work related to the mediaeval bridge Azzone Visconti in Lecco ( the “old bridge”). Metric information was acquired with different instruments and techniques for an integrated digital documentation that combines observations with variable precision: ±0.1 mm for the analysis of small vertical movements and subcentimeter precision for the geometrical reconstruction. The complexity of the bridge, with irregular constructive elements and different materials, required a detailed geometrical survey with laser scanning and photogrammetric techniques for the generation of plans and sections along with an accurate 3D parametric representation based on Building Information Modeling. A strategy based on NURBS curves and surfaces was implemented to overcome the lack of BIM libraries for historical constructions. Modeling was carried out at a metric scale 1:50 by assembling BIM objects following the logic of construction of the bridge. A semi-automated strategy that incorporates point clouds was developed to use information gathered by other data sources, such as historical analysis, destructive and non-destructive testing, and existing documentation. The monitoring project aimed at revealing vertical movements during loading tests. The measurement phase was carried out with a high-precision geometric leveling network made up of 47 benchmarks, resulting in redundant measurements adjusted via least squares techniques. The combined use of (i) photogrammetry and laser scanning for the 3D modeling project and (ii) geometric leveling for the analysis of vertical displacements allowed one to capture the metric information needed not only for specialists in the field of surveying, monitoring and modeling, but also for the other specialists (architects, engineers, etc.) involved in the project.
Forward Genetic Screens as Tools to Investigate Role and Mechanisms of EMT in Cancer

Simple Summary Forward genetic screens link genome modifications to phenotypes, and have been successfully employed to identify oncogenes, tumor suppressor genes and genes involved in metastasis or therapy resistance. In particular, transposon-based insertional mutagenesis screens and CRISPR-based screens are versatile and easy-to-use tools employed in recent years to discover and identify novel cancer-related mechanisms. In this review, we present the contribution of forward genetic screens to our understanding of how EMT is regulated and how it is involved in various aspects of cancer. Abstract Epithelial–mesenchymal transition (EMT) is a process of cellular plasticity regulated by complex signaling networks. Under physiological conditions, it plays an important role in wound healing and organ repair. Its importance for human disease is given by its central role in chronic fibroproliferative diseases and cancer, which represent leading causes of death worldwide. In tumors, EMT is involved in primary tumor growth, metastasis and therapy resistance. It is therefore a major requisite to investigate and understand the role of EMT and the mechanisms leading to EMT in order to tackle these diseases therapeutically. Forward genetic screens link genome modifications to phenotypes, and have been successfully employed to identify oncogenes, tumor suppressor genes and genes involved in metastasis or therapy resistance. In particular, transposon-based insertional mutagenesis screens and CRISPR-based screens are versatile and easy-to-use tools applied in recent years to discover and identify novel cancer-related mechanisms. Here, we review the contribution of forward genetic screens to our understanding of how EMT is regulated and how it is involved in various aspects of cancer. Based on the current literature, we propose these methods as additional tools to investigate EMT.
Role of novel biomarker IL-6 in the prediction of pre-term labor

Objective: To evaluate the diagnostic value of maternal serum interleukin 6 (IL-6), for the prediction of preterm labor. Association of few major maternal high risk factors and occurrence of preterm labor was also studied. Material and methods: Maternal serum IL-6 were prospectively determined in thirty patients in threatened preterm labor and thirty controls. Data was analyzed in study and control groups. Risk factors studied were maternal age, socioeconomic status, parity, antenatal checkup, history of preterm labor in previous pregnancy, history of 2 or more spontaneous or induced abortion, vaginal infection. Results: The strongest risk factor for preterm birth in our study is a previous preterm birth. In this study 60% mothers with history of preterm birth delivered preterm (p value 0.05). Maternal serum IL-6 levels were significantly higher in the study group than controls. The IL-6 value associated with the highest percent of true positives and true negatives for the prediction of preterm labor was 5 pg/ml. Conclusions: Maternal serum IL-6 is a reliable marker in the prediction and management of preterm labor and delivery.
Sexual Segregation in Vertebrates: Sex-related activities and social factors

Preface Part I. Overview: 1. Sexual segregation and the ecology of the two sexes Kathreen E. Ruckstuhl and Tim H. Clutton-Brock Part II. Concepts and Methodology: 2. Definitions, hypotheses, models and measures in the study of animal segregation Larissa Conradt Part III. Foraging Ecology: 3. Sex differences in the foraging ecology of large mammalian herbivores Johan T. du Toit 4. Sexual segregation in seals Ian J. Staniland 5. Sexual differences in foraging behaviour and diets: a case-study of wandering albatrosses Jose C. Xavier and John P. Croxall 6. Differences in foraging behaviour and feeding ecology in giant petrels Jacob Gonzales-Solis and John P. Croxall Part IV. Predator Avoidance and Reproductive Strategies: 7. Predation risk as a driving factor for size assortative shoaling and its implications for sexual segregation in fish Darren P. Croft, Jens Krause and Richard James 8. Differences in habitat selection and reproductive strategies of male and female sharks David W. Sims 9. Sex differences in reproductive strategies affect habitat choice in ungulates Martin B. Main and Johan T. du Toit Part V. Sex-related Activities and Social Factors: 10. Activity asynchrony and social segregation Kathreen E. Ruckstuhl and Peter Neuhaus 11. Sexual segregation in ungulates: from individual mechanisms to collective patterns Richard Bon, Jean-Louis Deneubourg, Jean-Francois Gerard and Pablo Michelena 12. Sexual segregation in humans Anthony D. Pellegrini, Jeffrey D. Long and Elizabeth A. Mizerek Part VI. Sexual Differences in Ecology: Comparisons within Different Taxa: 13. Ecological divergence between the sexes in reptiles Richard Shine and Mike Wall 14. Sexual segregation in Australian marsupials Abigail M. MacFarlane and Graeme Coulson 15. Social systems and ecology of bats John D. Altringham and Paula Senior 16. Sociality and ecology of the odontocetes Robert Michaud 17. Sexual segregation in non-human primates David P. Watts Part VII. Implications for Conservation: 18. Sexual segregation in birds: patterns, processes and implications for conservation Paulo Catry, Richard A. Phillips and John P. Croxal 19. Sexual segregation: a necessary consideration in wildlife conservation Esther S. Rubin and Vernon C. Bleich Part VIII. Outlook: 20. Conclusions and future directions Peter Neuhaus, Kathreen E. Ruckstuhl and Larissa Conradt References Index.
Clinical Candidates Targeting the ATR–CHK1–WEE1 Axis in Cancer

Simple Summary Selective killing of cancer cells is privileged mainstream in cancer treatment and targeted therapy represents the new tool with a potential to pursue this aim. It can also aid to overcome resistance of conventional chemo- or radio-therapy. Common mutations of cancer cells (defective G1 control) favor inhibiting intra-S and G2/M-checkpoints, which are regulated by ATR–CHK1–WEE1 pathway. The ATR–CHK1–WEE1 axis has produced several clinical candidates currently undergoing clinical trials in phase II. Clinical results from randomized trials by ATR and WEE1 inhibitors warrant ongoing clinical trials in phase III. Abstract Selective killing of cancer cells while sparing healthy ones is the principle of the perfect cancer treatment and the primary aim of many oncologists, molecular biologists, and medicinal chemists. To achieve this goal, it is crucial to understand the molecular mechanisms that distinguish cancer cells from healthy ones. Accordingly, several clinical candidates that use particular mutations in cell-cycle progressions have been developed to kill cancer cells. As the majority of cancer cells have defects in G1 control, targeting the subsequent intra‑S or G2/M checkpoints has also been extensively pursued. This review focuses on clinical candidates that target the kinases involved in intra‑S and G2/M checkpoints, namely, ATR, CHK1, and WEE1 inhibitors. It provides insight into their current status and future perspectives for anticancer treatment. Overall, even though CHK1 inhibitors are still far from clinical establishment, promising accomplishments with ATR and WEE1 inhibitors in phase II trials present a positive outlook for patient survival.
Disparities in Primary Care Wait Times in Medicaid versus Commercial Insurance

Background: Timely access to primary care is important, particularly among patients with acute conditions and patients seeking gateways to specialty care. Due to concerns that expanded Medicaid eligibility would compromise access to primary care among new Medicaid beneficiaries, an experimental study was conducted to test the ability to obtain timely appointments. Although access to primary care appointments for simulated Medicaid patients significantly increased, wait times also increased. This study explores the determinants of wait times and whether they pose greater barriers to Medicaid beneficiaries. Methods: We conducted linear regressions to determine the association between the number of days to scheduled appointments and the simulated patient's clinical scenario, practice-level characteristics, and county-level measures of primary care supply. Results: Simulated Medicaid patients faced 1.3 days longer wait times than commercially insured ones. Participation in accountable care organizations and integrated health systems was associated with longer wait times but did not seem to reduce wait time disparities across insurance types. Notably, the presence of Federally Qualified Health Centers in a given county was associated with lower wait times for simulated Medicaid patients. Conclusions: These findings highlight the complexity of access disparities for Medicaid patients and provide insight for future waves of health care reform.
‘Most stories of this type’: genre, horror and mystery in the silent cinema

An examination of ‘horror’ in the silent period, one of many genres that is only supposed to have emerged in the 1930s. Through an analysis of press coverage, the article examines a clear vocabulary that was used to describe a specific ‘type’ of film at the time. It also illustrates that ‘horror’ was explicitly used as a generic noun to name this ‘type’ but that, given that ‘horror’ was also a negative term used in censorship campaigns, this term was often avoided, except when ‘horror’ was clearly understood as a ‘hot’ genre. Consequently, this genre was more commonly described as ‘mystery,’ a term that included both ‘horror’ and ‘detective stories,’ terms that were largely seen to be indistinguishable in the period, when both were understood as featuring investigations into the ‘mysterious,’ ‘strange’ and ‘eerie. ’ In other words, ‘mystery’ staged a confrontation between rationality and irrationality and in a way that negotiated the perceived transitions from Victorianism to Modernity at the time.
A convex-nonconvex strategy for grouped variable selection

This paper deals with the grouped variable selection problem. A widely used strategy is to augment the negative log-likelihood function with a sparsity-promoting penalty. Existing methods include the group Lasso, group SCAD, and group MCP. The group Lasso solves a convex optimization problem but is plagued by underestimation bias. The group SCAD and group MCP avoid this estimation bias but require solving a nonconvex optimization problem that may be plagued by suboptimal local optima. In this work, we propose an alternative method based on the generalized minimax concave (GMC) penalty, which is a folded concave penalty that maintains the convexity of the objective function. We develop a new method for grouped variable selection in linear regression, the group GMC, that generalizes the strategy of the original GMC estimator. We present an efficient algorithm for computing the group GMC estimator and also prove properties of the solution path to guide its numerical computation and tuning parameter selection in practice. We establish error bounds for both the group GMC and original GMC estimators. A rich set of simulation studies and a real data application indicate that the proposed group GMC approach outperforms existing methods in several different aspects under a wide array of scenarios.
LINEAR-INVERSIVE GENERATOR OF PRN ' S WITH A VARIABLE MULTIPLIER

where y−1 n is a multiplicative inverse mod p m for yn if (yn, p) = 1. The parameters a, b, y0 we be called the multiplier, shift and initial value, respectively. In [3], [4], [6], [7], [8], [11], [12], [14] it was proved that under certain conditions on the parameters a, b, y0 the inversive congruential generator (1) produces a sequence {xn}, xn = yn pm , n ≥ 0, which passes s-dimensional serial tests on equidistribution and statistical independence for s ∈ {1, 2, 3, 4}.
Power analysis and instruction scheduling for reduced di/dt in the execution core of high-performanc

TOBUREN, MARK CHRISTOPHER. Power Analysis and Instruction Scheduling for Reduced di/dt in the Execution Core of High-Performance Microprocessors. (Under the direction of Dr. Thomas M. Conte.) Power dissipation is becoming a rst-order design issue in high-performance microprocessors as clock speeds and transistor densities continue to increase. As power dissipation levels rise, the cooling and reliability of high-performance processors becomes a major issue. This implies that signi cant research needs to be done in the area of architectural techniques for reducing power dissipation. One major contributor to a processor's average peak power dissipation is the presence of high di=dt in its execution core. High-energy instructions scheduled together in a single cycle can result in large current spikes during execution. In the presence of heavily weighted regions of code, these current spikes can cause increases in the processor's average peak power dissipation. However, if the compiler produces large enough regions, a certain amount of schedule slack should exist, providing opportunities for scheduling optimizations based on per-cycle energy constraints. This thesis proposes a novel approach to instruction scheduling based on the concept of schedule slack, which builds energy e cient schedules by limiting the energy dissipated in a single cycle. In this manner, a more uniform di=dt curve is generated resulting in a decrease in the execution core's average peak power dissipation. POWER ANALYSIS AND INSTRUCTION SCHEDULING FOR REDUCED di/dt IN THE EXECUTION CORE OF HIGH-PERFORMANCE MICROPROCESSORS
Innocent source of humanity

Purpose To identify the Transcendental Essence of Humanity, the purpose of this paper is to describe in brief what kind of research became possible when the theory of, e.g. autopoiesis, Husserl’s Transcendental Consciousness and the theory of Rhodes and Thame came together to form a “transcendental” interview methodology. Design/methodology/approach Critical conceptual implications are drawn to form a new research method to explore a de-subjectified inner domain and to search for a possible common essence of humanity. Findings A Transcendental Emotional Reference was found practically alien to contemporary perspectives. Still, the reference governs the emotional structure of human experience. This different perspective answers basic questions of morality, organization theory and leadership. Research limitations/implications The findings of the new research open a new and transparent perspective answering Grey’s question: “What is it to be human? ” (Grey, p. 47, 2014.) A perspective shedding new light on the humanities. A research limitation is the number of respondents. Still, being transcendental the findings are theoretically valid for all. Originality/value The paper is based on a unique research enabling 32+ (ongoing research) respondents to explore their own and universally shared Transcendental domain.
Characterization of somatostatin receptor in rat/mice brain : implication in Huntington's disease

ii Preface . iii Table of contents . v List of tables. xi List of figures . xii List of symbols and abbreviations . xv Acknowledgements . xviii Dedication . xix Chapter 1: Introduction . 1 1.1 Thesis overview . 1 1.2 Somatostatin . 4 1.3 Anatomical distribution of somatostatin . 5 1.4 Biological roles of somatostatin . 7 1.5 Somatostatin receptors . 9 1.6 Distribution of somatostatin receptor subtypes in central nervous system . 11 1.7 Role of somatostatin receptors in neurodegenerative diseases . 14 1.7. 1 NMDA-induced neurotoxicity . 14 1.7. 2 Huntington’s disease . 15 1.7. 3 Parkinson’s diseases . 17 1.7. 4 Alzheimer’s disease . 17 1.7. 5 Other neurodegenerative diseases . 19 1.8 Somatostatin receptor homo-and heterodimerization . 20
INFLUENCE OF SPRAY TIMING OF INSECTICIDE ON FORAGING DYNAMICS OF POLLINATORS ON SPONGE GOURD, LUFFA AEGYPTIACA MILL.

A field experiment was conducted to determine the Influence of best spray timing of insecticide on insect pollinators on sponge gourd, Luffa aegyptica Mill. at experimental field of Crop Protection Faculty, Sindh Agriculture University, Tando Jam during 2011. The results displayed that five species including bees, Xyllocopa sp. Apis dorsata, Apis mellifera, Syrphid fly, Eplyrphus baltaetus and Akk butterfly, Danias chrysippus were found on both sprayed and unsprayed plots. The data depicted that maximum population was observed in insect pollinators, Xylocopa sp. and Apis dorsata (0.11/flower) followed by Apis melifera and Syrphid fly (0.07/flower) and Akk butter fly (0.03/flower) at 7 to 10 a.m. whereas, the minimum foraging activity was determined at 1 to 4 p.m. in treated plot in respective insect pollinators. The highest reduction in population was observed in Akk butterfly (69.05%) at 7 a.m. whereas the minimum reduction % was seen (45.24%) in Apis dorsata at 1 p.m. in treated plot. The analysis of the data showed that there is significant difference (P<0.05) among the spray timings and reduction in population in respective insect pollinators. Therefore, the maximum population dynamics was displayed (0.25/flower) in Apis dorsata followed by Xylocopa sp. (0.24/flower), Apis melifera (0.18/flower), Syrphidfly (0.13/flower) and Akk butterfly (0.10/flower) at 7 to 10 a.m. whereas, the minimum population was observed during 1 to 4 p.m. in untreated plot in respective insect pollinators. The correlation of insect pollinators showed positive relationship with temperature oC and relative humidity % have negative relationship with population at 7 to 10 a.m. in treated and untreated plots respectively. Similarly, insect pollinators has negative correlation with temperature oC and relative humidity % at 1 to 4 p.m. in treated and untreated plot respectively. The analysis of the data shows highly significant difference (P<0.05) among the spray timings. Whereas, reduction in population also significantly different from each other (P<0.05).