Miracle-dz/UniFAR-FTUs huggingface dataset:
Temporal trends and barriers for inpatient palliative care referral in metastatic gynecologic cancer patients receiving specific critical care therapies

Objective Existing evidence suggests that palliative care (PC) is highly underutilized in metastatic gynecologic cancer (mGCa). This study aims to explore temporal trends and predictors for inpatient PC referral in mGCa patients who received specific critical care therapies (CCT). Methods The National Inpatient Sample from 2003 to 2015 was used to identify mGCa patients receiving CCT. Basic characteristics were compared between patients with and without PC. Annual percentage change (APC) was estimated to reflect the temporal trend in the entire cohort and subgroups. Multivariable logistic regression was employed to explore potential predictors of inpatient PC referral. Results In total, 122,981 mGCa patients were identified, of whom 10,380 received CCT. Among these, 1,208 (11.64%) received inpatient PC. Overall, the rate of PC referral increased from 1.81% in 2003 to 26.30% in 2015 (APC: 29.08%). A higher increase in PC usage was found in white patients (APC: 30.81%), medium-sized hospitals (APC: 31.43%), the Midwest region (APC: 33.84%), and among patients with ovarian cancer (APC: 31.35%). Multivariable analysis suggested that medium bedsize, large bedsize, Midwest region, West region, uterine cancer and cervical cancer were related to increased PC use, while metastatic sites from lymph nodes and genital organs were related to lower PC referral. Conclusion Further studies are warranted to better illustrate the barriers for PC and finally improve the delivery of optimal end-of-life care for mGCa patients who receive inpatient CCT, especially for those diagnosed with ovarian cancer or admitted to small scale and Northeast hospitals.
Mathematical Models of HIV-1 Dynamics, Transcription, and Latency

HIV-1 latency is a major barrier to curing infections with antiretroviral therapy and, consequently, to eliminating the disease globally. The establishment, maintenance, and potential clearance of latent infection are complex dynamic processes and can be best described with the help of mathematical models followed by experimental validation. Here, we review the use of viral dynamics models for HIV-1, with a focus on applications to the latent reservoir. Such models have been used to explain the multi-phasic decay of viral load during antiretroviral therapy, the early seeding of the latent reservoir during acute infection and the limited inflow during treatment, the dynamics of viral blips, and the phenomenon of post-treatment control. Finally, we discuss that mathematical models have been used to predict the efficacy of potential HIV-1 cure strategies, such as latency-reversing agents, early treatment initiation, or gene therapies, and to provide guidance for designing trials of these novel interventions.
Global Nitrogen Mass Flux From the Active Freshwater Aquifer Element Pool

The estimated current global mean nitrogen concentration (geogenic + anthropogenic) in the active continental freshwater aquifer element pool is 1.1 mg/L as N, or between four and five times greater than the assumed geogenic mean. This concentration, combined with groundwater flux, generates a continental mass flux of 17 Tg N/y (teragrams of nitrogen, as N, per year) as a result of direct ocean discharge (0.67 Tg N/y), endorheic basins (1.2 Tg N/y), and cold‐wet (0.82 Tg N/y); cold‐dry (1.4 Tg N/y); warm‐dry (1.6 Tg N/y); and warm‐wet (11 Tg N/y) exorheic basins. These values are derived from a geospatial machine learning algorithm and combined groundwater‐modeled recharge in an ArcGIS environment. This active continental freshwater aquifer mass flux is between 35% and 40% of the continental integrated riverine system discharge, thus a significant component of the Earth's active continental freshwater nitrogen budget. We estimate the active continental freshwater aquifer volume to be between 1.4 and 2.8 million km3 suggesting a legacy of between 1.5 and 3.1 Pg as N (petagrams nitrogen as N) with mean residences of 90–180 years.
Numerical Study of Eastern Boundary Ventilation and Its Effects on the Thermocline Structure

Abstract Numerical experiments with idealized OGCM are carried out to investigate the oceanic eastern boundary problems. The experimental results indicate that the eastward flow due to the north–south gradient of the surface density returns to the interior region through the lower half of the mixed layer, and this return flow generates a density jump just above the thermocline. Formulation for the mixed layer depth distribution at the eastern boundary is also presented, which is derived only from the geostrophy and no-normal flow condition. This formulation agrees well with the numerical experiment, and can be an appropriate eastern boundary condition for theoretical ventilated thermocline model with no deficiency of the mass balance on the boundary. Furthermore, the effects of such eastern boundary structure on the subtropical thermocline are studied. On the shallow thermocline in the subtropics, eastern boundary ventilated region emerges, which is identified as a region of high potential vorticity. In t.
KRT17 from skin cells with high glucose stimulation promotes keratinocytes proliferation and migration

Impaired diabetic wound healing is an important issue in diabetic complications. Proliferation and migration of keratinocytes are major processes of skin wound repair after injury. However, hyperkeratosis can affect the speed of wound healing. Based on the results of preliminary experiments on increased KRT17 expression after high glucose stimulation of human skin tissue cells, a cell model of human immortalized keratinocyte (HaCaT) stimulation with different concentrations of KRT17 was established in vitro, and the promotion in cell proliferation and migration were discovered. KRT17 silencing promoted diabetic wound healing in the db/db diabetic wound model. Transcriptome sequencing (RNA-seq) was performed on HaCaT cells after KRT17 stimulation, and analysis showed significant enrichment in the PI3K-AKT signaling pathway, in which the regulation of cell c-MYB mRNA, a key molecule regulating cell proliferation and migration, was significantly upregulated. In vitro assays showed increased c-MYB expression and enhanced pAKT activity after HaCaT cell stimulation by KRT17. We speculate that KRT17 is upregulated under high glucose and promotes keratinocyte proliferation and migration caused hyperkeratosis, through the c-MYB/PI3K-AKT pathway, contributing to delayed wound healing.
Mercury's tides and interior structure

[1] An accurate tide-generating potential series for Mercury has been calculated on the basis of VSOP87 ephemerides for the solar system planets. Due to the 3:2 spin-orbit resonance, the tides on Mercury cannot be divided into the three classically known tidal frequency bands for the Earth: the diurnal, semidiurnal, and long-period tides. Instead, the tides all have periods of the order of one Mercury day, or, equivalently, one Mercury year, and their amplitudes have been calculated with an accuracy of 10−5 m2s−2. Basic Mercury models with varying inner and outer core radii and core sulfur concentration have been constructed in order to test the sensitivity of tides to these parameters. To determine the reaction of Mercury to the tidal forcing, the Love numbers h, l, and k and the gravimetric factor δ were calculated for the interior models. Tidal displacements, gravity variations, and external gravitational potential variations have also been calculated for the models. It is shown that especially the measurement of the external potential variations will be extremely useful for constraining the inner and outer core.
Key design characteristics that influence the performance of stormwater biofilters

Biofilters can be used as a tool to treat urban stormwater and help combat the pollution of watercourses, whilst also offering the opportunity to attenuate and retain stormwater flows. However, their large scale implementation is being hindered by lack of knowledge about the key factors that influence their ability to remove pollutants from stormwater. This paper presents the biofilter design characteristics and operating conditions that influence Total Suspended Solids (TSS), Total Phosphorus (TP) and Total Nitrogen (TN) removal efficiency. The significance of these characteristics was identified by analyzing data from three laboratory-scale biofilter column studies. We found that the most significant factors influencing treatment performance are vegetation presence and type, filter media characteristics (orthophosphate and TN contents), filter media depth, and antecedent soil moisture content. This knowledge can later be used to create a simple predictive model of expected TSS, TP and TN treatment by biofilters.
Peace Festival Project as Culture Commidified in DMZ Area, Korea

Tourism, because of its peculiar nature, depends much on security and safety at the destination. Likewise, Korea needs to assure concrete security and safety to develop tourism in particular. In new millennium, however, Korea has a major issue to be solved. That is to decrease the political tension between South and North so as to accelerate the reunification of the peninsula. In this context, the peace festival tourism project should be placed in the first priority since this will ease the strained political relations between South and North. This paper attempts to review the actual condition of the peace festival tourism project and to examine economic, socio-cultural and political impacts. To analyze the effects of the study, secondary data and information provided by the research & research agency, newspaper articles and the Bank of Korea were utilized.
Preset-Time and Preset-Accuracy Human-in-the-Loop Cluster Consensus Control for MASs Under Stochastic Actuation Attacks

This article investigates a preset-time and preset-accuracy human-in-the-loop cluster consensus control approach for nonlinear multi-agent systems (MASs) on a directed graph under stochastic actuation attacks. First, a new preset-time and preset-accuracy Zeno-free event-triggered observer that requires neither each agent to access the human agent information nor the first $(n-1)$ derivatives of the human agent output is designed by using a preset-time and preset-accuracy convergence performance function. Based on this observer, a preset-time and preset-accuracy intrusion-tolerant controller is put forward for every follower agent, wherein the preset-time convergence and steady-state cluster consensus accuracy are assigned a priori. It is worth mentioning that the control strategy is designed in the form of a transformed error, which not only avoids the infinite gain at the preset-time instant but also operates continuously even beyond the preset-time interval. Meanwhile, the preset time and preset accuracy are not affected by the initial conditions, so that the performance function can be preset arbitrarily. To confirm the effectiveness and advantages of the theoretical results, the proposed strategy for cluster consensus control with preset time and preset accuracy is applied to a single link manipulator system.
Protective Effect of Hedeoma drummondii against Formaldehyde-Induced Testicular Toxicity and Genotoxicity in Wistar Rats

Formaldehyde (FA) is an oxidative stress inducer and a known carcinogen. Hedeoma drummondii has been shown to have potential as a chemopreventive agent. The aim of this study was to assess the protective effect of H. drummondii on FA-induced genotoxic damage, sperm quality parameters, and histological changes of the testis. The male Wistar rats used were divided into the following groups: (G1) 100 mg/kg H. drummondii; (G2) 10 mg/kg FA; (G3) 100 mg/kg H. drummondii + 10 mg/kg FA; (G4) phosphate-buffered saline; (G5) 100 mg/kg α-tocopherol; (G6) 100 mg/kg α-tocopherol + 10 mg/kg FA; and (G7) soybean oil. The results showed a sperm concentration of 23.66 ± 1.52 versus 33.67 cells/mL ( p = 0.02 ), and a percentage of motility of 29.66 ± 1.51 versus 33.33 ( p = 0.620 ), for groups G3 and G6, respectively. Histopathological (H&E) and immunohistochemical analysis of superoxide dismutase showed damage in the germinal epithelium (GE) in G2. While in groups G3 and G6, the histological structure was preserved. A protective effect on sperm DNA fragmentation was also observed for treated groups (G3 and G6, p < 0.0001 vs. G2). While in groups G3 and G6 the histological structure was preserved. A protective effect on sperm DNA fragmentation was also observed for treated groups (G3 and G6). In conclusion, FA exposure significantly reduces sperm quality parameters, causes sperm DNA damage, and alters GE in the testis, while H. drummondii has a protective effect against FA-induced sperm genotoxic damage, similar to α-tocopherol.
Encoder-Free Multiaxis Physics-Aware Fusion Network for Remote Sensing Image Dehazing

Current methods for remote sensing image dehazing confront noteworthy computational intricacies and yield suboptimal dehazed outputs, thereby circumscribing their pragmatic applicability. To this end, we propose encoder-free multiaxis physics-aware fusion network (EMPF-Net), a novel EMPF-Net that exhibits both light-weighted characteristics and computational efficiency. In our pipeline, we contend that conventional u-shaped networks allocate substantial computational resources to encode haze-degraded features, which play a subordinate role in the reconstruction process. Consequently, our encoder stages solely incorporate down-sampling operations. To improve the representation efficiency and enhance the generalization capabilities, we devise a multiaxis partial queried learning block (MPQLB) that primarily concentrates on learning dimension-wise queries, instead of relying solely on strictly correlated content of the input features. Furthermore, we augment the reconstruction procedure by incorporating ground truth supervision into each stage via a supervised cross-scale transposed attention module (SCTAM). It calculates attention maps under the guidance of clean images, thereby suppressing less informative features to propagate to the subsequent level. In addition, to address the challenge of ineffective intralevel feature fusion, which result in insufficient elimination of haze-degraded information and have a negative impact on the quality of reconstructed images, we introduce a physics-aware intralevel fusion module (PIFM). This module harnesses a physical inversion model to facilitate the intralevel feature interaction and alleviate the interference of dehazing-irrelevant information. Our proposed EMPF-Net is evaluated on 12 publicly available datasets, and the experimental results substantiate our superiority in terms of both metrical scores and visual quality, despite being equipped with a modest parameter count of 300k. Our approach is readily accessible at https://github.com/chdwyb/EMPF-Net.
Mapping thermokarst lakes in different physical states on the central Tibetan plateau

ABSTRACT Mapping and monitoring the spatial–temporal evolution of thermokarst lakes on the Tibetan Plateau can significantly contribute to the estimation of climate change impacts on permafrost degradation. Remote sensing-based methods have been developed to monitor the interannual changes of thermokarst lakes. However, the seasonal changes, which are vital for understanding thermokarst lake dynamics, are commonly overlooked. This paper developed automatic methods which integrated the normalized difference water index (NDWI), modified normalized difference water index (MNDWI), principal component analysis (PCA), and independent component analysis (ICA) with Markov random field (MRF) for rapid mapping of thermokarst lakes in different physical states characterized by season changes. To validate the effectiveness, the proposed methods were applied to map thermokarst lakes on the central Tibetan Plateau, using four Sentinel-2 images representing different evolutionary states. Specifically, the area-to-point regression kriging (ATPRK) method was employed to downscale the 20-m short-wave infrared (SWIR) band to 10 m. Using manually digitized lakes as a reference, the proposed methods achieved an average Kappa coefficient of 0.79, significantly outperforming the water index thresholding method that merely attained 0.44. The results corroborate that the proposed methods can be robustly applied in mapping thermokarst lake dynamics with both interannual and seasonal trends on the Tibetan Plateau.
Plasmodium Infection–Cure Cycles Increase the Capacity of Phagocytosis in Conventional Dendritic Cells

Malaria stands as one of the most pervasive human infectious diseases globally and represents a prominent cause of mortality. Immunity against clinical malaria disease is achieved through multiple infection and treatment cycles, culminating in a substantial reduction in parasite burden. To investigate this phenomenon, we established a murine model involving repeated infection–cure cycles, whereby mice were infected with the lethal rodent malarial parasite Plasmodium berghei ANKA and subsequently treated with the anti-malarial drug pyrimethamine. Our earlier study revealed a significant decrease in the capacity of conventional dendritic cells (cDCs) to produce cytokines upon stimulation in infection-cured mice. In the present study, we aimed to further elucidate the modulation of cDC functionality during repeated infection–cure cycles by examining their phagocytic capacity. Administering fluorescent beads to mice resulted in no significant difference in the total number of bead-positive cells within the spleens of both uninfected and 3-cure (three cycles of infection–cure) mice. However, the proportion of the CD11c+F4/80− population within bead-positive cells was notably higher in 3-cure mice compared to uninfected mice. Subsequent in vitro analysis of bead phagocytosis by purified CD11c+cDCs revealed that the cDC2 subset from 3-cure mice exhibited significantly enhanced phagocytic capacity in comparison to their uninfected counterparts. These findings underscore the substantial impact of repeated infection–cure cycles on various facets of cDC function, potentially influencing the trajectory of immune responses against subsequent malaria infections.
Theory and Key Technology of Updating Geospatial Database Based on Multiresource Spatial Data

Integration and updating of geospatial data is a key problem in Geomatics. Conflation and integration computer environment of multi-scale spatial data are valid implement technology of spatial data integration. The unified information service platform of multi-resource spatial data is an effective means to get spatial information service. Using satellite image data and applying GIS spatial objects generalization technology to update spatial database are effective approaches. In this paper, the theory and technology of spatial data integration and updating are throughly analyzed, and we also present that integration of geospatial data enhances the service ability of spatial database, and the updating upgrade the value of geospatial information service.
Progonocimicids (Hemiptera, Coleorrhyncha) from the Middle Jurassic Haifanggou Formation, western Liaoning, northeast China support stratigraphic correlation with the Daohugou beds

Jiang, J.-Q. , Cai, C. -Y. & Huang, D. -Y. , October 2015. Progonocimicids from the Middle Jurassic Haifanggou Formation, western Liaoning, northeast China support stratigraphic correlation with the Daohugou beds. Alcheringa 40, XXX–XXX. ISSN 0311-5518. The hemipteran suborder Coleorrhyncha includes only 37 extant species assigned to the family Peloridiidae. However, the suborder’s fossil record is diverse and abundant. The extinct family Progonocimicidae is very common in Middle Jurassic strata of northeastern China, especially in the Daohugou beds of Ningcheng County, Inner Mongolia, and the Haifanggou Formation in Beipiao, Liaoning Province. We re-studied the established progonocimicid species and examined 27 new specimens, indicating that the species from Daohugou are junior synonyms of those from Haifanggou. The progonocimicids from the Haifanggou Formation are assigned to two species of Cicadocoris: C. brunneus (=Mesoscytina brunnea, =Mesocimex lini) and C. sinensis (=Cicadocoris anisomeridis). Both species are common in the Daohugou beds and the Haifanggou Formation. This discovery is of significance for biostratigraphic correlation of these two lithostratigraphic units. It also contributes to our understanding of the geological age of the famous Daohugou biota, which has yielded the earliest known feathered dinosaurs and diverse early mammals. Jia-Qian Jiang [jiaqianjiang@126.com], State Key Laboratory of Palaeobiology and Stratigraphy; Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, Nanjing 210008, PR China; and Graduate School, University of Chinese Academy of Sciences, 19A Yuquanlu, Beijing 100049, PR China. Chen-Yang Cai [caichenyang1988@163.com], Di-Ying Huang [dyhuang@nigpas.ac. cn], State Key Laboratory of Palaeobiology and Stratigraphy, Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, Nanjing 210008, PR China.
An Active Resistor for Ultra Low Power Applications

The paper regards a new active resistor for ultra-low power applications. Thanks to the chosen topology, based on feedback and operational amplifier, it allows to accurately emulate the voltage versus current characteristic (V-I) of a component with respect to the process, temperature and power supply variations. Furthermore, using a transistor in a series configuration as reference, it is possible to obtain very high resistance values with up to 10 times less area with respect to the resistors available in standard complementary metal-oxide-semiconductor (CMOS) technology. The circuit has been simulated using 1.2-V transistors of a 130nm CMOS technology. Compared with a standard p+ poly-silicon resistors, it exhibits equivalent performance parameters using less area.
Global Warming and Climate Change - Effect and Strategies for its Mitigation

This article surveys predicted and projected rates of glohal warming and climate change due to emission of GHGs and their consequences especially effects on nature , society , glaciers and stream flow , agriculture and fauna. Effects on forests may result in shift of species , drop in productivity and growth , increased incidence of insects. To counter these problems , a worldwide strategy has to be taken up to mitigate or slow down these processes. In this strategy the international agencies can playa dominant role in fixing targets for reduction of emission. Geo-engineering can be put to use but the forests have the biggest opportunity as they absorb CO 2 and function as carbon sinks. The introduction of carbon credits is advocated , as an incentive.