Miracle-dz/UniFAR-FTUs huggingface dataset:
Attachment Representations and Emotion Regulation Strategies in Parents of Children with Disruptive Behaviour Disorders

Although a growing body of research suggests a robust association between insecure attachment, emotion regulation problems and externalizing problems, as Disruptive Behaviour Disorders (DBD), in children, only a few studies have explored these constructs in their parents. Moreover, the role of the father is often neglected. The current study aimed to investigate attachment representations and emotion regulation strategies in parents with DBD children (considering mothers and father separately), compared with a comparison group. The research involved 100 Italian parents: 36 clinical parents (18 mothers and 18 fathers) of children aged 8-12 years with a diagnosis of DBD, and 64 parents (32 mothers and 32 fathers) of children with no clinical symptoms. Parents’ attachment representations were assessed through the Adult Attachment Interview and their emotional regulation strategies through the Emotion Regulation Questionnaire. The clinical status of children was the result of an evaluation by two mental health experts and a compilation by both parents of the Child Behavior Checklist 6-18 Version. Our results pointed to a greater presence of Insecure-Entangled attachment in DBD mothers and a lower level of Cognitive Reappraisal in DBD fathers compared with comparison parents. Nevertheless, maternal Insecure and paternal Cognitive Reappraisal did not together predict children DBD as the outcome. These preliminary findings make a significant contribution to the topic of emotional functioning of DBD parents, suggesting the importance to further deepen the quality of parenting in the context of DBD children. 1 Department of Educational Science, University of Genoa, Italy E-mail corresponding author: fabiola.bizzi@edu.unige. it
Proposal of Continuous Audit Model Data Integration Framework

The approximation of business areas with the use of new technologies, real-time savings, transactions with several countries and on several continents with different law guarantees are necessary. These warranties can be acquired through Continuous Audit (CA). Some research contributions may be listed as: provide a standardization of data and nomenclatures for the data used by Continuous Audit procedures; re-use of previously developed detection and analysis algorithms; reduction of the development and implementation costs of the processes of continuous audit in organizations due to the standardization of data and the reutilization of algorithm; encouragement for the creation of a repository of public access algorithms. The paper also aims to contribute to the literature with the deepening of ways to access, structure and collect critical and / or necessary data for CA. With the deepening of Audit Data Standard and eXtensible Business Reporting Language (XBRL), as well as creating a basis for future research with the integration of extraction, analysis and exception detection algorithms that are used by CA. Keywords-Continuous Audit; XBRL; Audit; Audit Framework
Progressive Exertional Dyspnea and Fatigue in an Oncology-Patient

Background: Progressive fatigue even further dyspnea are common between oncology patients; however the development of these symptoms in a patient who has been treated with some of the new immune checkpoint inhibitors must make us thinking of a possible adverse event of these drugs. Case Report: We report a case of a 78-year-old man with a history of ischemic heart disease, who presented with fatigue, elevated myocardial enzymes and atrioventricular block in the electrocardiogram. He had been diagnosed of lung cancer and included in a clinical study with combination therapy of ipilimumab and nivolumab. Further investigation during hospitalization revealed also neuromuscular, thyroid and neurological affectation. Also we started immunosuppressive therapy, the patient died fewer days after diagnosis. Conclusion: We report a case of myocarditis due to new immune checkpoint inhibitors use for cancer treatment. Although this type of toxicity has yet been reported, we still lack of a score risk to predict high risk patients or genetic predisposing. Since an early diagnosis and prompt treatment could prevent the fast development we encourage medical practitioners to retain a high degree of suspicion.
Growth Promotion of Switchgrass by Bacterial Endophyte Pantoea agglomerans Strain PaKM Isolated from Seeds

Switchgrass is one of the most promising bioenergy crops for the US. It produces relatively high biomass yield and can grow on marginal lands. However, some traits need to be improved, including stand establishment and stress tolerance. We previously reported that Burkholderia phytofirmans PsJN promoted growth of switchgrass cv. Alamo. However, PsJN was found to be genotype specific in promoting switchgrass growth. In an effort to identify endophytes which have a broad spectrum of growth promotion with more efficiency, we isolated a bacterium from surface-sterilized switchgrass seeds. The bacterium was identified as a Pantoea agglomerans species and named strain PaKM. Our experiments demonstrated that PaKM significantly boosts switchgrass growth/vigor and root system development, and increases biomass yield under in vitro, growth chamber, greenhouse, as well as field conditions. Not only does PaKM promote growth of switchgrass Alamo, but also 8 other switchgrass cultivars tested. PaKM also enhanced salt and drought stress tolerance in vitro. Assays demonstrated that PaKM has the ability to solubilize phosphate and produces high levels of auxin. In summary, PaKM is an efficient growth promoter of switchgrass over a broad spectrum of genotypes and has potential application with low input and sustainable production systems on marginal lands.
ArticleA new GaN-based Device

This paper attempts to disclose a new GaN-based device, called the P-Cascode GaN HEMT, which uses only a single gate driver to control both the D-mode GaN and PMOS transistors. The merit of this synchronous buck converter is that it can reduce the circuit complexity of the synchronous buck converter, which is widely used to provide non-isolated power for low-voltage and high-current supply to system chips; therefore, the power conversion efficiency of the converter can be improved. In addition, the high side switch using a single D-mode GaN HEMT, which has no body diode, can prevent the bi-directional flow and thus reduce the power loss and cost compared to a design based on a series of two opposite MOSFETs. The experiment shows that the proposed P-Cascode GaN HEMT efficiency is above 98% when it operates at 500 kHz with 6 W output. With the input voltage at 12 V, the synchronous buck converter provides an adjustable regulated output voltage from 1.2 V to 10 V while delivering a maximum output current of 2 A.
Effects of Cigarette Smoking History on Neurocognitive Recovery Over 8Months of Abstinence in AlcoholDependent Individuals

Background: This study compared the rate and extent of recovery on measures of learning and memory, processing speed, and working memory in treatment-seeking alcohol-dependent individuals (ALC) who were never smokers (nvsALC), former smokers (fsALC), and active smokers (asALC) over the first 8 months of sustained abstinence from alcohol. Assessments after 1 week, 1 month, and 8 months of abstinence in ALC enabled a comparison of the rates of neurocognitive changes from 1 week to 1 month versus 1 to 8 months of abstinence. Methods: ALC and never-smoking controls were administered standardized measures of auditoryverbal and visuospatial learning and memory, processing speed, and working memory. Controls completed a baseline assessment and a follow-up approximately 9 months later. Results: Over 8 months of abstinence, asALC showed poorer recovery than nvsALC on visuospatial learning, and both fsALC and asALC recovered less than nvsALC on processing speed measures. The corresponding recovery rates for the ALC group, as a whole, were greater from 1 week to 1 month than from 1 to 8 months of abstinence; these findings were largely driven by improvements in nvsALC. The recovery levels for fsALC on most measures were similar to those in asALC. Additionally, over 8 months, asALC showed significantly less improvement with increasing age than nvsALC on measures of processing speed and learning and memory. At 8 months of abstinence, asALC were inferior to controls and nvsALC on multiple measures, fsALC performed worse than nvsALC on several tests, but nvsALC were not different from controls on any measure. Conclusions: Overall, ALC showed rapid improvement on measures of visuospatial learning and processing speed during the first month of abstinence from alcohol. Results also provide robust evidence that smoking status influenced the rate and level of neurocognitive recovery over 8 months of abstinence in this ALC cohort.
CMAR_A_307695 4203..4215

1Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, 515031, People’s Republic of China; 2Department of Radiation Oncology, Dongguan Tungwah Hospital, Dongguan, 523110, People’s Republic of China; 3Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, People’s Republic of China
PAPERS Docking approach of inhibitor design for p-secretase of Alzheimer's disease

Amyloid plaques are pathological markers and at the same time indirect cause of Alzheimer's disease. P-secretase catalyzes the cleavage of the amyloid precursor protein and hence the formation of amyloid peptide. Thus, plaque formation could be indirectly hindered by the development of P-secretase inhibitors. In our study, a computational approach of rational drug design for P-secretase is presented. Known inhibitor-enzyme complexes were used for validation of computational docking of the peptides of this system. Predictions were made for the atomic details of the complexes of potent inhibitors.
for the management of medical conditions

GUIDELINES for the management of medical conditions are being used increasingly both in hospitals and in primary health care settings. Their popularity is one response to the greater complexity of medical decision making and the rapid expansion of diagnostic and therapeutic capabilities. Continuing refinements in the treatment of some conditions can result in an expanding range of medical responses to specific conditions which may lead to greater variation in possible outcomes. Protocols for the management of acute myocardial infarction, gastro-intestinal bleeding, or diabetic ketoacidosis are now common in hospital medicine. They reflect a provisional consensus amongst specialists over how to maximize the chances of survival given the currently available treatments and the results of outcome studies. Guidelines can also provide junior hospital doctors and general practitioner trainees with a practical framework within which to assess, monitor and treat patients with complex chronic or acute illness. Following clinical guidelines can help to structure observation, interpretation and understanding, whilst at the same time helping to contain uncertainties on the part of those in training. To this extent, it might be expected that doctors with different levels of experience and expertise would be likely to use clinical guidelines in different ways. Increasing awareness of the need to use limited resources cost-effectively has provided an added impetus to the development of guidelines. Several studies have documented large variations in the rate of hospital referral by general practitioners. Although some of the variation may be explained by the availability of consultants, and also perhaps by chance, much of it remains unexplained (Morris and Roland 1988; Moore and Roland, 1989). For example, differing characteristics of patients, list size, age or the training of general practitioners do not appear to be significant determinants of referral rate (Acheson, 1986; Wilkin and Smith, 1987). In Islington, variability in the number and appropriateness of referrals by general practitioners as perceived by hospital consultants was an important stimulus to the development of the guidelines published here.
Unicellular Ca Signaling ‘Toolkit’ at the Origin of Metazoa

Ca2þ signaling pathways control many physiological processes in almost all types of animal cells such as fertilization, muscle contraction, hormone release, and learning and memory. Each animal cell type expresses a unique group of molecules from the Ca2þ signaling ‘toolkit’ to control spatiotemporal patterns of Ca2þ signaling. It is generally believed that the complex Ca2þ signaling ‘toolkit’ has arisen from the ancestral multicellular organisms to fit unique physiological roles of specialized cell types. Here, we demonstrate for the first time the presence of an extensive Ca2þ signaling ‘toolkit’ in the unicellular choanoflagellate Monosiga brevicollis. Choanoflagellates possess homologues of various types of animal plasma membrane Ca2þ channels including the store-operated channel, ligand-operated channels, voltageoperated channels, second messenger-operated channels, and 5 out of 6 animal transient receptor potential channel families. Choanoflagellates also contain homologues of inositol 1,4,5-trisphosphate receptors. Furthermore, choanoflagellates master a complete set of Ca2þ removal systems including plasma membrane and sarco/endoplasmic reticulum Ca2þ ATPases and homologues of 3 animal cation/Ca2þ exchanger families. Therefore, a complex Ca2þ signaling ‘toolkit’ might have evolved before the emergence of multicellular animals.
Noninvasive In Vivo Characterization of Human Carotid Plaques with Acoustic Radiation Force Impulse (ARFI) Ultrasound: Comparison with Histology Following Endarterectomy

Ischemic stroke from thromboembolic sources is linked to carotid artery atherosclerotic disease with a trend toward medical management in asymptomatic patients. Extent of disease is currently diagnosed by noninvasive imaging techniques that measure luminal stenosis, but it has been suggested that a better biomarker for determining risk of future thromboembolic events is plaque morphology and composition. Specifically, plaques that are composed of mechanically-soft lipid/ necrotic regions covered by thin fibrous caps are the most vulnerable to rupture. An ultrasound technique that noninvasively interrogates the mechanical properties of soft tissue, called acoustic radiation force impulse (ARFI) imaging, has been developed as a new modality for atherosclerotic plaque characterization using phantoms and atherosclerotic pigs, but the technique has yet to be validated in vivo in humans. In this preliminary study, in vivo ARFI imaging is presented in a case-study format from four patients undergoing clinically-indicated carotid endarterectomy and compared to histology. In two type Va plaques, characterized by lipid/necrotic cores covered by © 2014 World Federation for Ultrasound in Medicine amp; Biology. All rights reserved. Corresponding author: cmgallip@bme.unc. edu, Phone: (919) 843-6647, Address: 152 MacNider Bldg. CB #7575, Chapel Hill, NC 27599, USA. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author Manuscript Ultrasound Med Biol. Author manuscript; available in PMC 2016 March 01. Published in final edited form as: Ultrasound Med Biol. 2015 March ; 41(3): 685–697. doi:10.1016/j.ultrasmedbio. 2014.09. 016. N IH -P A A uhor M anscript N IH -P A A uhor M anscript N IH -P A A uhor M anscript fibrous caps, mean ARFI displacements in focal regions were high relative to the surrounding plaque material, suggesting soft features covered by stiffer layers within the plaques. In two type Vb plaques, characterized by heavy calcification, mean ARFI peak displacements were low relative to the surrounding plaque and arterial wall, suggesting stiff tissue. This pilot study demonstrates the feasibility and challenges of transcutaneous ARFI for characterizing the material and structural composition of carotid atherosclerotic plaques via mechanical properties, in humans, in vivo.
CLEP_A_258373 1029..1038

1Centre for Pharmacoepidemiology, Karolinska Institutet, T2, Karolinska University Hospital, Stockholm, Sweden; 2The National Board of Health and Welfare, Stockholm, Sweden; 3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Purpose: To evaluate associations between first-time use of direct oral anticoagulants or vitamin K antagonists and bleeding risk or mortality in the elderly with atrial fibrillation in a real-world setting in Sweden. Patients and Methods: The study population comprises first-time users, above age 60, of dabigatran, apixaban, rivaroxaban, or warfarin, with first atrial fibrillation occurrence within 6 months before dispensing (2012–2016). Outcomes were gastrointestinal, any, or intracranial bleeding, and mortality. Exposure started at first dispensing of a study drug. Follow-up continued until outcome, end of drug supply, dispensing of another study drug, death or end of study (December 2016). We conducted a propensity score matched, nationwide register-based cohort study including three treatment groups: direct thrombin inhibitors, direct factor Xa inhibitors and vitamin K antagonists, each compared to the other two, focusing on subgroups of age and sex. Cox proportional hazard models adjusted for CHA2DS2VASc and HAS-BLED scores provided hazard ratios with 95% confidence intervals. Results: The matched study populations consisted of 7,264 patients for the direct thrombin inhibitors vs vitamin K antagonists comparison, 12,566 patients for the direct factor Xa inhibitors vs vitamin K antagonists comparison and 6,606 patients for the direct factor Xa inhibitors vs direct thrombin inhibitors comparison, in total 26,436 patients. Numerically high, but imprecise, hazard ratios for gastrointestinal bleeding were observed for women aged 75–80, 80–85, or above 85 years, eg 6.00 (1.02, 113.47) for direct thrombin inhibitors vs vitamin K antagonists. For both sexes, numerically high hazard ratios for any bleeding were observed in ages 80–85, or above 85 years, eg 2.90 (1.01, 10.41) for direct thrombin inhibitors vs vitamin K antagonists. Numerically high HRs for intracranial bleeding were observed for women aged 75–80 or 80–85 years, eg 2.70 (0.65, 18.19) for direct factor Xa inhibitors vs vitamin K antagonists. Excess mortality was observed in both sexes, across age groups, for naive and experienced anticoagulant users. Conclusion: The observed increased gastrointestinal bleeding risk in first-time users of direct thrombin inhibitors or direct factor Xa inhibitors is consistent with previous studies. The possible risk of excess mortality merits further studies.
Masters Thesis: A Study on Yaw-Misaligment: Combined Optimization of Wind Farm Power Production and Structural Loading

Climate change gives incentive for the transition to sustainable energy sources such as wind energy. To make wind energy cost competitive with fossil fuel sources, wind turbines are commonly placed in groups. As wind turbines extract energy from the wind, a wake occurs behind the turbine characterized by reduced a wind speed and increased turbulence. This wake causes down stream turbines to incur decreased power production and increased loading. Due to this aerodynamic interaction between these turbines, the energy production is sub-optimal. A control strategy to mitigate these losses is by imposing yaw misalignment with the incoming wind flow. This induces a lateral force which will cause the wake to deflect, with the goal to avoid downstream turbines. A side effect of wake deflection is partial wake overlap which has the potential to increase the fatigue loading of wind turbines. One way to decrease the cost of energy, is to increase the power production without significantly affecting the loads. Therefore, this thesis aims to quantify the load variations due to partial wake overlap and evaluate the benefits of a combined optimization of power and loads over traditional control strategies. For this purpose, we design a computational framework which computes the wind farm power production and the wind turbine rotor loads based on the yaw settings. To investigate the influence of partial wake overlap on the rotor fatigue, the differential flapwise and edgewise bending moments at hub height are computed. FLORIS is used to compute the power and CCBlade to determine the loads, supplemented with an algorithm to find the velocity distributions as hub height. The optimal yaw settings are found using a gradient-based optimization algorithm algorithm. The simulation results show that partial wake overlap can significantly increase asymmetric loading of the rotor and that yaw misalignment is beneficial in situations where the wake can be sufficiently directed away from the downstream turbines. Furthermore, a combined optimization of power and loads in all wind directions has been found to increase the average power production by 1.53% and decrease the average differential flapwise and edgwise loads by respectively 42.67% and 45.70% compared to greedy control settings. Although results are promising, Master of Science Thesis Mike T. van Dijk
Bone Marrow in Perspectives to Cure Breast Cancer

There are perspectives to cure breast cancer, and the main strategy in that way is the exact estimation of tumor dissemination at diagnosis. It is well proved that disseminated tumor cells in the bone marrow are the most important prognostic factor in operable breast cancer [1]. Its prognostic role become visible at late periods after surgery (sometimes, 25 years). Taking in mind that women with breast cancer are around 60-year-old, one may see that the relapses arises usually after 80. It appears in brain, lung and other distant organs as hematologic metastases, and unfortunately, nothing is possible to do in the most of those cases, so the main reasons of deaths in breast cancer are distant metastases.
OTT_A_208926 5389..5393

1The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing 210008, People’s Republic of China; 2Department of Oncology of Yizheng Hospital, Nanjing Drum Tower Hospital Group, Yizheng 211400, People’s Republic of China; 3Department of General Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, People’s Republic of China; 4Department of Pathology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, People’s Republic of China; 5Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, People’s Republic of China; 6Department of Oncology, Nanjing Second People’s Hospital, Nanjing 210003, People’s Republic of China; 7The Medical Department, 3D Medicines Inc, Shanghai 201114, People’s Republic of China Background: Gallbladder cancer (GBC) is the main pathological type of biliary tract