Miracle-dz/UniFAR-FTUs huggingface dataset:
Modeling of volatile contamination transport for surface operations of the Mars Science Laboratory

Gas-phase contamination modeling for space systems typically looks at the free molecular flow regime, Knudsen number » 1, wherein transport is characterized by collisionless motion of contaminant molecules and deposition proportional to grey- or black-body view factors. Such an approach, however, was not applicable to the contamination transport environment [to be] encountered by the NASA Mars Science Laboratory (MSL) during surface operations on the Red Planet. For MSL, we required an understanding of contaminant transport under the Mars-ambient conditions of an approximately 8 Torr CO2 atmosphere in order to provide traceability between hardware outgassing limits and the allowable vapor-phase contaminant concentrations in the vicinity of atmospheric sampling sensors and deposition to prospective solid sample sites on the Martian surface. In setting outgassing requirements for the MSL surface system, an engineering upper-bound estimate--rather than a precise result based on an all-inclusive simulation of the dynamic flow field--of the local contamination density was needed. Here we describe a 3-D, low-speed computational fluid dynamics approach, including molecular diffusion, to determine mixing ratios of contaminants at the atmospheric sample inlets and solid sample inlet deposition rates. Turbulence enhances the effective diffusion, leading to the dilution of the volatile contaminants, which reduces contamination concentration at a distance far from the source in comparison to inviscid or laminar flow fields: Therefore, the approach employed here results in a conservative upper bound compared to one in which turbulence is explicitly addressed. Because contaminant transport in this environment (Peclet number in the range of 50-1000) is advection dominated, spatial contamination concentration is a strongly-peaked function of the wind direction. Results of sample calculations for expected Mar wind speeds (u = 1-20 m/s) and several wind directions are presented.
The effect of contraction on a homogeneous turbulent shear flow

A homogeneous turbulent shear flow in its asymptotic stage of development was subjected to an additional (longitudinal) strain by passing the flow through gradual contraction in the direction perpendicular to that of the mean shear. Two contractions, of area ratio 1.4 and 2.6, were used. Mean velocity and turbulent stress (both normal and shear) distributions were measured at several streamwise locations in the contraction region. The mean velocity distributions agree quite well with calculations based on the (inviscid) Bernoulli equation. Until at least half-way down the contraction with the larger area ratio, the rapid-distortion calculations considering only the streamwise acceleration were found to be reasonably successful in predicting the turbulent intensities. For the smaller-area-ratio contraction, corrections for the ‘natural development’ of the shear flow become important nearly everywhere. Similar calculations considering the shear as the only straining mechanism are generally less successful, although the shear strain rate is at least as rapid as, or even more so than, the longitudinal one. The pressure-rate-of-strain covariance terms estimated from the approximate component energy balance were used to test the adequacy of three models with varying degrees of complexity. Although none of these models appears general enough, their performance is generally adequate for the lower-area-ratio contraction; perhaps not surprisingly, the more complex the model the better its performance.
The influence of structural parameters of CCD on the reconstruction image of digital holograms

The influence of structural parameters of CCD including the size of the pixel, sampling interval and sensitive area on the reconstruction image of digital holograms is discussed. We find that such associating structural parameters interacting with the system related to the optical arrangement for recording the digital holograms, have influences on the brightness, the size and the resolution of the reconstruction image. Considering these influences, we suggest an optimal optical setup for recording high quality digital holograms.
Cervical Lymph Node Metastasis From Recurrent Glioblastoma Detected by MRI and 2-[18F]FDG PET/CT.

ABSTRACT A 53-year-old man diagnosed with recurrent glioblastoma after multimodal treatment on a follow-up brain MRI. Because of a palpable mass in the neck, the patient underwent a whole-body 2-[18F]FDG PET/CT, which revealed hypermetabolic laterocervical confluent lymphadenopathies. A nodal cervical biopsy indicated distant metastases from glioblastoma. Recent studies have confirmed dural meningeal lymphatics, as part of the glymphatic system, which provide clearance of interstitial solutes from the brain parenchyma into cervical lymphatics. Nodal cervical metastases from glioblastoma, using this pathway, are extremely rare and have been almost unthinkable some years ago.
Dimensional Error Compensation Based on Data-Driven Sliding Mode Terminal Iterative Learning Control for CNC Batch Grinding

Dimensional error of workpiece is an important index that indicts the grinding accuracy of machine tools. Conventional error compensation strategies focus on modeling one or several error factors for a particular CNC machining type, which are time consuming and costly. Based on data-driven sliding mode terminal iterative learning control, a new dimensional error compensation method is proposed in this paper. The compensation algorithm based on an iterative sliding surface and an objective function is established using the terminal experimental data. A modified NC program is fed to the machine tool to push the workpiece dimension towards desired. The theoretical analysis and experimental results show the proposed compensation method can effectively improve the batch grinding accuracy of the machine tool, which shows good perspective in manufacturing industry.
A laser-driven undulator x-ray source: simulation of image formation and dose deposition in mammography

Since overcoming some of the inherent limitations of x-ray tubes becomes increasingly harder, it is important to consider new ways of x-ray generation and to study their applications in the field of medical imaging. In the present work we investigate a novel table-top-sized x-ray source, developed in a joint project within the Cluster of Excellence "Munich Center for Advanced Photonics". It uses laser-accelerated electrons emitting x-ray radiation in a short period undulator. This source has the potential to deliver tunable x-rays with a very narrow spectral bandwidth. The main purpose of this contribution is to investigate the performance of this source in the field of mammography and to compare it to that of conventional x-ray tubes. We simulated the whole imaging process from the electron beam dynamics through the generation of the synchrotron radiation in the undulator up to the x-ray-matter interaction and detection in the mammographic setting. A Monte Carlo simulation of the absorption and scattering processes based on the Geant4 software toolkit has been developed that uses a high-resolution voxel phantom of the female breast for the accurate simulation of mammography. We present simulated mammograms generated by using quasi-monochromatic undulator radiation and by using the polychromatic spectrum of a conventional x-ray tube.
Delivery of B. subtilis into Animal Intestine Using Chitosan-Derived Bioresorbable Gel Carrier: Preliminary Results

The oral delivery of bacteria in the human intestine is of great interest because of its potential to correct the gut microbiota and treat inflammatory bowel diseases. The aim of this study was to evaluate sodium N-(2-sulfonatoethyl)chitosan gel cross-linked with glutaraldehyde as a delivery carrier for probiotic bacteria to the gut using in vitro and in vivo experiments. The bacterial test strain was B. subtilis 20. The cytotoxicity of the gel was evaluated via cell culture using flow cytometry and light microscopy. The gel as a delivery system was assessed by the dye release in medium with different pH levels in vitro, and by bacterial titer monitoring in mouse feces using the microbiology method in vivo. Results of an in vitro experiment showed that tested gel has no cytotoxicity. The use of gel as a carrier for bacterial delivery into the intestine was more effective than oral gavage of bacterial suspension. Therefore, gel delivery of bacteria decreased the titer level by up to two times. However, a gavage of bacterial suspension decreased the titer level by over 200 times. Tested gel has the potential to be a carrier for the safe delivery of bacteria to the intestine through the stomach, reducing the rate of the elimination of probiotic bacteria from the intestine.
Effects of Thermal Treatment on the Mechanical Properties of Bamboo Fiber Bundles

Bamboo is known as a typical kind of functional gradient natural composite. In this paper, fiber bundles were extracted manually from various parts of the stem in the radial direction, namely the outer, middle, and inner parts. After heat treatment, the mechanical properties of the fiber bundles were studied, including the tensile strength, elastic modulus, and fracture modes. The micromechanical properties of the fiber cell walls were also analyzed. The results showed that the mean tensile strength of the bamboo fiber bundles decreased from 423.29 to 191.61 MPa and the modulus of elasticity increased from 21.29 GPa to 27.43 GPa with the increase in temperature. The elastic modulus and hardness of the fiber cell walls showed a positive correlation with temperature, with the modulus of elasticity and the hardness increasing from 15.96 to 18.70 GPa and 0.36 to 0.47 GPa, respectively. From the outside to the inside of the bamboo stems, the tensile strength and elastic modulus showed a slight decrease. The fracture behavior of the fiber bundles near the outside approximates ductile fracture, while that of the bundles near to the inside tend to be a brittle fracture. The fracture surfaces of the bamboo bundles and the single fibers became smoother after heat treatment. The results show that bamboo fiber bundles distributed near the outside are most suitable for industrial development under heat treatment at 180 °C. Therefore, this study can provide a reasonable scientific basis for the selective utilization, functional optimization, and bionic utilization of bamboo materials, which has very important theoretical and practical significance.
Langevin unification of fractional motions

We present a physical Langevin-based theory explaining the emergence and pervasiveness of the following ‘fractional motions’: Brownian motion, Lévy motion, fractional Brownian motion and fractional Lévy motion. A general form of micro-level Langevin dynamics, with infinitely many degrees of freedom, is considered. Transcending from the micro-level to the macro-level the infinitely many degrees of freedom collapse to two characteristic exponents, and the aforementioned fractional motions emerge universally. The exponents categorize the fractional motions and determine their statistical and topological properties. The theory establishes a unified ‘Langevin bedrock’ to fractional motions—which are widely applied prototypical models of random transport in the sciences.
An intelligent vision recognition method based on deep learning for pointer meters

Nowadays, pointer instruments remain the main state monitoring devices in the power industry, because they have strong mechanical stability to resist electromagnetic interferences compared with digital instruments. Although the object detection algorithms based on deep learning have widely been used in the field of instrument detection, the meter recognition process still relies on threshold segmentation to recognize object points and on Hough transform to extract the meter pointer. An intelligent vision recognition method based on YOLOv5 and U2-Net network (YLU2-Net) is proposed to improve the accuracy and efficiency of meter recognition in a complex environment. Firstly, the pointer meter is located in the instrument images by using the YOLOv5 network as a region of interest (RoI). Then, the instrument RoI is processed by means of perspective transformation and image resizing. Thirdly, an improved U2-Net image segmentation method with the deep separable convolution and the focal loss function is devised to distinguish the pointers and scales from the background in the instrument RoI. Further, a dimension reduction reading method with the polar coordinate transformation is developed to calculate the meter reading accurately and efficiently. Finally, the ablation experiment is conducted to test the performance of each algorithm module in our method, and the competition experiment is completed to compare our method with other state-of-the-art ones. The experimental results verify the accuracy and efficiency of the YLU2-Net recognition method proposed.
Tectonic advection of contacts enhances landscape transience

Contrasts in bedrock erodibility have been shown to drive landscape transience, but it is unclear whether horizontal tectonic displacements would enhance such effects. Furthermore, one might expect these factors to coexist, as tectonic convergence helps to create rock strength contrasts in settings like the Himalayas. How do landscapes respond when contacts separating units are raised vertically and shifted horizontally by tectonics? To evaluate such questions, we use landscape evolution models to simulate the exposure of a weak unit in a landscape equilibrated to a strong unit. We explore different simulations varying factors like weak unit erodibility, diffusivity, contact dip, and topographic advection rate. In these simulations, we assess the migration of the main drainage divide as well as changes in channel steepness and topographic relief within the strong unit. Our model results show that the horizontal movement of a contact does enhance drainage divide migration and increases in channel steepness, especially when the contact migrates along rivers with low drainage areas. Across all simulations, however, increases in topographic relief are minimal and temporary. Unexpected behaviors emerge in our simulations in which the mass balance of topography is influenced by horizontal tectonic displacements. For example, the exposure of the weak unit causes a gradual decline in the steepness of the strong unit. We interpret such behaviors to be artifacts related to the fixed boundaries of our domain and likely unrepresentative of natural landscapes. Instead, we focus on simulations where advection does not influence the mass balance of topography. These models show that the horizontal movement of contacts can enhance landscape transience, but this transience is marked by features one can use as diagnostic characteristics. Detecting such characteristics in natural landscapes featuring tectonic convergence would be difficult, however, due to the natural coincidence of factors such as faulting, folding, and landslides.
Ethosomes: a potential nanocarrier for transdermal drug delivery‏

Ethosomal system is a lipid vesicular nanocarrier that holds a high concentration of alcohols. This nanocarrier is optimized for the dermal and transdermal delivery of medicinal drugs with various physicochemical features. Since its release in 1996, ethosomes have been subjected to subsequent studies to modify the original formula via the addition of different components, leading to the development of novel ethosomal system types. These new carriers are prepared via a variety of methods and characterized through different parameters, including vesicular size, zeta potential, entrapment efficiency, and skin permeation. The ethosomes efficacy in dermal/transdermal administration is evaluated via clinical studies as well as a wide range of in vivo models. Ethosomal dispersions are frequently incorporated into topical preparations, including gels, patches, and lotions, due to their stability and convenience. This article provides a thorough overview of ethosomal systems from the standpoint of ethosomal types, beginning with classical ethosomes and progressing to binary ethosomes and transethosomes. In addition, this work provides a comprehensive overview of the components of the ethosomal system and their contribution to the final properties of ethosomes, besides highlighting the different methods of preparation and the common dosage forms used as ethosomes' vehicles.
Concurrent Trypanosomosis, Babesiosis and Toxocarosis in a Dog: a Case Report

Background: Among the blood-borne parasitic infections of dogs, trypanosomosis and babesiosis are highly prevalent in the Indian subcontinent and highly pathogenic. Methods: A six-month-old dog was presented with complaint of lethargy, anorexia and loss of body weight over the previous 15 days on October 11, 2021. A full clinical and targeted haematologic and parasitological examination was undertaken. Results: Wet smears were positive for the motile trypanosomes while stained thin blood smears showed large number of extracellular trypanosomes and intra-erythrocytic ring-like inclusion bodies of Babesia spp. A high burden of Toxocara canis was identified on coprological examination. Conclusion: This report describes the clinical manifestation of concurrent infection of haemoparasites and gastrointestinal nematodes in Pakistani dogs, and highlights the importance of prompt veterinary intervention.
Interfacial properties of single-crystalline CeO2 high-k gate dielectrics directly grown on Si (111)

Interfacial properties of single-crystalline CeO2 high-k dielectrics directly grown on Si (111) were investigated by comparing metal–insulator–semiconductor field-effect transistors (MISFETs) without any interfacial layer [(w/o-IL); direct growth of CeO2 on Si] and those with an interfacial layer (w-IL). FET characteristics, such as the drain current and the S factor, for the w/o-IL MISFET were much worse than those for the w-IL MISFET. The in-gap states attributed to the oxygen defects were detected in the CeO2 directly grown on Si by x-ray photoelectron spectroscopy measurements. The large interface state density induced by the oxygen defects at the CeO2/Si interface may deteriorate the w/o-IL MISFET performances.
AVE 0991 Suppresses Astrocyte-Mediated Neuroinflammation of Alzheimer’s Disease by Enhancing Autophagy

Purpose Our previous study has shown that AVE 0991, a nonpeptide analogue of Ang-(1-7), ameliorates cognitive decline and inhibits NLRP3 inflammasome of astrocytes in Alzheimer’s disease model mice. Additionally, several studies have suggested that activation of autophagy appears to effectively inhibit the progression of neuroinflammation. However, it is unclear whether AVE 0991 can modulate astrocyte autophagy to suppress neuroinflammation in Alzheimer’s disease. Materials and Methods APP/PS1 mice and Aβ-treated primary astrocytes were used as the research objects in vivo and in vitro, respectively. Water maze test was used to evaluate cognitive function of mice, Nissl staining and immunofluorescence staining was used to assess neuronal damage. ELISA kits were used to detect the levels of Ang-(1-7) and Aβ in the cortex, and qRT-PCR was used to detect the expression of cortical inflammation-related mediators. The expression of autophagy-related proteins in cortex were detected by Western blot. The upstream molecular responses involved in inflammation inhibition by AVE 0991 were validated by means of using the Mas1 antagonist and autophagy inhibitor. Results We found that 30 days of intraperitoneal administration of AVE 0991 improved. Aβ deposition, neuronal death, and cognitive deficits in APP/PS1 Alzheimer’s disease model mice. Moreover, AVE 0991 treatment greatly suppressed astrocyte-mediated inflammation and up-regulated the expression of autophagy. Furthermore, the inhibitory effect of AVE 0991 on the expression of inflammatory factors was reversed by 3-MA, an autophagy inhibitor. Conclusion These findings suggest that regulation of autophagy is critical for inhibiting astrocyte neuroinflammatory responses and demonstrate a potential neuroprotective mechanism by which AVE 0991 could suppress neuroinflammatory responses by enhancing autophagy.
Robust variance estimation for rate ratio parameter estimates from individually matched case-control data

The asymptotic variance and robust variance estimators of rate ratios estimated using conditional logistic regression from individually-matched case-control data are derived when the presumed proportional hazards model is misspecified. The robust variance estimators are easily computed using Schoenfeld residuals generated from standard partial likelihood estimation software for failure time data. Simulation studies indicate that the robust variance estimators perform well for typical sizes and that the 'rare disease' version should be adequate for all practical purposes. It was also found that model misspecification must be quite extreme before the model-based, i.e. inverse information, variance is significantly biased and that the robust variance estimators are somewhat more variable than the model-based. We conclude that the model-based variance estimator can be used when model misspecification is not severe. The robust estimator should be used when the presumed model clearly fits the data poorly. Copyright Biometrika Trust 2003, Oxford University Press.
TIME-RESOLVED ANALYSIS IN TRANSMISSION ELECTRON MICROSCOPY AND ITS APPLICATION TO THE STUDY OF THE DYNAMICS OF VORTICES

A new method for investigating dynamic processes in transmission electron microscopy is proposed and demonstrated for Lorentz microscopy measurement of vortex motion in a Nb thin film. A selected portion of the electron beam current, modulated by the dynamics of the specimen, is led through the probe aperture at the image plane and measured as sequential counts of electrons or as a correlation function. The free energy barrier of the vortex hopping and the local creeping velocity are determined. In addition, the feasibility of observing the elastic flow of vortices is shown. {copyright} {ital 1997} {ital The American Physical Society}