Miracle-dz/UniFAR-FTUs huggingface dataset:
Multi-Scale Superpixels Dimension Reduction Hyperspectral Image Classification Algorithm Based on Low Rank Sparse Representation Joint Hierarchical Recursive Filtering

The original Hyperspectral image (HSI) has different degrees of Hughes phenomenon and mixed noise, leading to the decline of classification accuracy. To make full use of the spatial-spectral joint information of HSI and improve the classification accuracy, a novel dual feature extraction framework joint transform domain-spatial domain filtering based on multi-scale-superpixel-dimensionality reduction (LRS-HRFMSuperPCA) is proposed. Our framework uses the low-rank structure and sparse representation of HSI to repair the unobserved part of the original HSI caused by noise and then denoises it through a block-matching 3D algorithm. Next, the dimension of the reconstructed HSI is reduced by principal component analysis (PCA), and the dimensions of the reduced images are segmented by multi-scale entropy rate superpixels. All the principal component images with superpixels are projected into the reconstructed HSI in parallel. Secondly, PCA is once again used to reduce the dimension of all HSIs with superpixels in scale with hyperpixels. Moreover, hierarchical domain transform recursive filtering is utilized to obtain the feature images; ultimately, the decision fusion strategy based on a support vector machine (SVM) is used for classification. According to the Overall Accuracy (OA), Average Accuracy (AA) and Kappa coefficient on the three datasets (Indian Pines, University of Pavia and Salinas), the experimental results have shown that our proposed method outperforms other state-of-the-art methods. The conclusion is that LRS-HRFMSuperPCA can denoise and reconstruct the original HSI and then extract the space-spectrum joint information fully.
Hybrid Polymer Composites Used in the Arms Industry: A Review

Polymer fiber composites are increasingly being used in many industries, including the defense industry. However, for protective applications, in addition to high specific strength and stiffness, polymer composites are also required to have a high energy absorption capacity. To improve the performance of fiber-reinforced composites, many researchers have modified them using multiple methods, such as the introduction of nanofillers into the polymer matrix, the modification of fibers with nanofillers, the impregnation of fabrics using a shear thickening fluid (STF) or a shear thickening gel (STG), or a combination of these techniques. In addition, the physical structures of composites have been modified through reinforcement hybridization; the appropriate design of roving, weave, and cross-orientation of fabric layers; and the development of 3D structures. This review focuses on the effects of modifying composites on their impact energy absorption capacity and other mechanical properties. It highlights the technologies used and their effectiveness for the three main fiber types: glass, carbon, and aramid. In addition, basic design considerations related to fabric selection and orientation are indicated. Evaluation of the literature data showed that the highest energy absorption capacities are obtained by using an STF or STG and an appropriate fiber reinforcement structure, while modifications using nanomaterials allow other strength parameters to be improved, such as flexural strength, tensile strength, or shear strength.
Comparative Transcriptome-Based Mining of Senescence-Related MADS, NAC, and WRKY Transcription Factors in the Rapid-Senescence Line DLS-91 of Brassica rapa

Leaf senescence is a developmental process induced by various molecular and environmental stimuli that may affect crop yield. The dark-induced leaf senescence-91 (DLS-91) plants displayed rapid leaf senescence, dramatically decreased chlorophyll contents, low photochemical efficiencies, and upregulation of the senescence-associated marker gene BrSAG12-1. To understand DLS molecular mechanism, we examined transcriptomic changes in DLS-91 and control line DLS-42 following 0, 1, and 4 days of dark treatment (DDT) stages. We identified 501, 446, and 456 DEGs, of which 16.7%, 17.2%, and 14.4% encoded TFs, in samples from the three stages. qRT-PCR validation of 16 genes, namely, 7 MADS, 6 NAC, and 3 WRKY, suggested that BrAGL8-1, BrAGL15-1, and BrWRKY70-1 contribute to the rapid leaf senescence of DLS-91 before (0 DDT) and after (1 and 4 DDT) dark treatment, whereas BrNAC046-2, BrNAC029-2/BrNAP, and BrNAC092-1/ORE1 TFs may regulate this process at a later stage (4 DDT). In-silico analysis of cis-acting regulatory elements of BrAGL8-1, BrAGL42-1, BrNAC029-2, BrNAC092-1, and BrWRKY70-3 of B. rapa provides insight into the regulation of these genes. Our study has uncovered several AGL-MADS, WRKY, and NAC TFs potentially worthy of further study to understand the underlying mechanism of rapid DLS in DLS-91.
Effect of metal surfaces in on-surface glaser coupling

The homocoupling of alkynes at metal surfaces, which was disclosed recently, is a promising reaction for efficient construction of conjugated nanostructures at metal surfaces. However, the role of the metal substrate as well as the mechanistic course of this process have not been investigated. The metal surface could act cooperatively (a) for two-dimensional confinement to properly orient the organic reactant and (b) also as an active mediator in the C–C bond-forming reaction. Herein we report covalent coupling of the dimers of 1,4-diethynylbenzene at various metal surfaces. The model reaction was investigated experimentally by STM and also by theoretical DFT calculations. Detailed statistical analysis and the theoretical results strongly support the involvement of the metal surface in the C–C bond-forming process. On the basis of these investigations, a model with two possible reaction pathways is suggested to describe the process: C–C coupling via direct CH activation and C–C coupling via alkynyl activa.
ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange

Low‐density lipoprotein (LDL)‐cholesterol delivery from late endosomes to the plasma membrane regulates focal adhesion dynamics and cell migration, but the mechanisms controlling it are poorly characterized. Here, we employed auxin‐inducible rapid degradation of oxysterol‐binding protein‐related protein 2 (ORP2/OSBPL2) to show that endogenous ORP2 mediates the transfer of LDL‐derived cholesterol from late endosomes to focal adhesion kinase (FAK)‐/integrin‐positive recycling endosomes in human cells. In vitro, cholesterol enhances membrane association of FAK to PI(4,5)P2‐containing lipid bilayers. In cells, ORP2 stimulates FAK activation and PI(4,5)P2 generation in endomembranes, enhancing cell adhesion. Moreover, ORP2 increases PI(4,5)P2 in NPC1‐containing late endosomes in a FAK‐dependent manner, controlling their tubulovesicular trafficking. Together, these results provide evidence that ORP2 controls FAK activation and LDL‐cholesterol plasma membrane delivery by promoting bidirectional cholesterol/PI(4,5)P2 exchange between late and recycling endosomes.
Schottiin, a new prenylated isoflavones from Psorothamnus schottii and antibacterial synergism studies between methicillin and fremontone against methicillin-resistant Staphylococcus aureus ATCC 1708

Abstract Bioactivity guided isolation of an ethanol extract of the root of Psoromanthus schottii (Family Fabaceae) afforded a new prenylated isoflavone, named schottiin (5,7,5’-trihydroxy-4’-O-methyl-6’-(3,3-dimethylallyl)-isoflavone) (1), together with four other isoflavones, including fremontone (2), 5,7,4’,5’-tetrahydroxy-2’-(3,3-dimethylallyl)-isoflavone (3), glycyrrhisoflavone (4) and fremontin (5), of which 3 and 4 identified as isomeric mixture. Structures of 1-5 were determined by full spectroscopic analyses. A comprehensive 2 D NMR spectral data has allowed revising the structure of fremontone as 2 from previously reported 2 A. Compound 2 showed weak in-vitro antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). A combination study using a checkerboard assay between fremontone (2) and methicillin exhibited a synergistic activity with 8-fold decrease in MIC of methicillin, as well as an additive effect with vancomycin against MRSA ATCC 1708. Compounds 1 and 2 also showed moderate antiplasmodial activity against chloroquine-sensitive (D6) and -resistant (W2) strains of Plasmodium falciparum with no cytotoxicity to mammalian Vero cells. Graphical Abstract
Attribute Amnesia in the Auditory Domain

Individuals are often unable to report an attribute of an object to which they recently attended, if they expected to report a different attribute, a phenomenon known as attribute amnesia (AA). To date, all AA studies have occurred in the visual domain. The purpose of this study was to explore the boundary conditions of AA by testing if AA also occurs in the auditory domain and, if so, for which attributes. It was found that AA was present when reporting the location (p = .003) and the number of tones (p < .001) of an auditory stimulus, but not when reporting its pitch (p = .383). These findings can be understood in terms of the organisation of the primary cortical areas and help explain the differences between visual working memory and auditory working memory.
Innovative educational approaches to house calls in the time of COVID‐19

It is estimated that 1.9 million older adults are completely homebound with many more requiring the assistance of others to leave their home. Many of these patients are best served with home-based medical care, and yet medical trainees receive limited training to provide care in the home environment. Incorporating house calls into residency training is integral to teaching resident physicians about the care of homebound older adults. Although the COVID-19 pandemic has shifted medical education online, it remains important that we provide opportunities for trainees to build longitudinal primary care relationships, learn geriatric care in the home environment, and receive feedback from attending preceptors directly observing their clinical care. The Johns Hopkins Home-based Medicine (JHOME) program provides home-based primary care to older adults in Baltimore, Maryland, and is a unique opportunity for longitudinal training in this setting. Internal medicine residents in the general internal medicine (GIM) track of the Johns Hopkins Bayview (JHB) Internal Medicine Residency Program follow a panel of 4–5 homebound older adult patients during their second and third years of residency and see them at home every 3 months during their community-based practice rotation. Typically, attending preceptors and residents see patients in the home together, allowing preceptors to directly observe the visit and provide feedback. In response to the COVID-19 pandemic, the JHOME team adapted house call education to limit the number of visitors in the home while still preserving opportunities for practice-based learning. Following 9 months of piloting several visit approaches, we surveyed residents to gather their perspectives and plan for future education.
Socio-Demographic Predictors of Willingness to Pay for Premium of National Health Insurance: A Cross-sectional Survey of Six Districts in Sierra Leone

Background: The government of Sierra Leone introduced Social Health Insurance Scheme as a measure to remove financial barriers that beset the people in accessing health to ensure universal coverage. Under this policy, the citizens were encouraged to subscribe to the scheme to avoid out of pocket payment for healthcare at the point of use. This study was conducted to find out the predictors of willingness among the people to pay for health insurance premium. Methods: A cross-sectional study design was employed in six selected districts in Sierra Leone. Quantitative data was collected for this study through the use of semi-structured questionnaire with a sample size of 1185 respondents. Data was analysed into descriptive and inferential statistics using the contingent valuation model. Statistical analysis was run at 5% significant level using Stata version 14.0 software. Results: The results showed that majority of the respondent are willing to join and pay a monthly premium of Le 10 000 (US$1.03) with an estimated mean contribution of about Le 14 089 (US$1.44) and the top five predictors of willingness to pay (WTP) were household monthly income, age, district of resident, gender, and educational qualification. Conclusion: The findings on predictors of WTP premium of Sierra Leone National Social Health Insurance (SLeNSHI), suggests that the socio-demographic characteristics of the population are important in premium design and payment. Efforts at improving the socio-economic statuses of the population could be helpful in premium design and payment.
Plastic brains and gastrointestinal strains: The microbiota–gut–brain axis as a modulator of cellular plasticity and cognitive function (commentary on Darch et al., 2021)

The last decade has witnessed rapid advances in DNA sequencing technologies and bioinformatic approaches, leading to fast and cost-effective phylogenetic identification of microbial communities and gut microbiota in particular. These breakthroughs have been revolutionary for different fields, from ecology and agriculture to biological and medical sciences. Remarkably, the communication between these trillions of microorganisms, the gut they inhabit and the brain has been found to be both extensive and dynamically bidirectional. The microbiota–gut–brain axis has been associated with mechanisms mediating neurodevelopment, behaviour, cognition and many neurological and psychiatric disorders (Cryan et al., 2019). This extra level of complexity has been revealed with respect to brain function and dysfunction and fits into a broader conceptualisation of the centrality of bidirectional brain–body interactions in health and disease. Does this mean that more neuroscientists should consider the role of the microbiota–gut–brain axis in their studies of brain structure and function? A new study in this issue of EJN adds weight to this argument, particularly for those who study learning, memory and associated cellular plasticity. Darch et al. (2021) provided new insights into the role of the microbiome as a potential modulator of synaptic plasticity in the hippocampus of adult mice. They evaluated the electrophysiological properties of hippocampal slices from germ-free (GF) adult mice (C57/Bl6 wild types at 8–12 weeks of age), raised in the absence of microbiota, in comparison with their conventionally (Conv) raised counterparts. While the GF mice showed normal basal synaptic excitability and presynaptic function, postsynaptic long-term potentiation (LTP) was altered in GF male (but not female) mice, demonstrating sex-dependent changes in synaptic plasticity in the absence of microbiota (keeping in mind that GF mice lack microbes in all parts of their body, not just the gut). However, the hippocampal CA1 neurons of these GF mice showed enhanced dendritic input–output coupling (both sexes), suggesting a compensatory hyperexcitability. In summary, Darch et al. (2021) uncover a sex-specific alteration in dendritic signalling and associated synaptic plasticity in the hippocampus of mice induced by the absence of microbiota. These findings have implications for how we might understand the regulation of synaptic plasticity and associated learning and memory mechanisms. These new Received: 20 May 2021 Revised: 1 June 2021 Accepted: 2 June 2021
Mapping the morphological changes of deposited gold nanoparticles across an imprinted groove

The gradient gold layer morphology below the percolation threshold along a channel groove imprinted into a pressure-sensitive adhesive polymer film is studied. In order to elucidate the complex nanostructure of the sputter-deposited gold nanoparticle layer, nanobeam grazing-incidence small-angle X-ray scattering and imaging ellipsometry are used. Thus, the complex nanostructure of this metal–polymer nanocomposite can be detected, distinguished and identified. The presence of macroscopically curved structures, as introduced by the imprinted ridges, can cause deviations from the mean metal nanoparticle morphology, probed on the `flat' sample area outside the ridges. The phase-separated morphology of the polymer film is rather unaffected by the imprint structure but leads, in addition, to a selective growth of gold on polystyrene-rich domains.
Psilocybin and MDMA for the treatment of trauma-related psychopathology

Abstract This review examines the role of trauma in psychiatric morbidity and analogous psychoneurobiological changes. Trauma is a necessary criterion for Post-Traumatic Stress Disorder (PTSD), however, trauma history is highly correlated with a variety of psychiatric conditions. Some evidence suggests that Major Depressive Disorder (MDD) is the most common psychiatric condition that arises following trauma. Approximately 50% of PTSD cases present with co-morbid MDD. Overlapping symptomatology and neurobiology between these conditions underlie the debate over whether these phenomena result from problematic nosology or whether comorbid MDD + PTSD is a distinct phenotype of trauma-related psychopathology. Regardless, similar treatment approaches have been employed historically, with varying success. The drug-assisted psychotherapy treatment model, which combines pharmacological and psychotherapeutic approaches, is currently being trialled as a novel treatment approach in psychiatry. Both psilocybin- and 3,4-Methylenedioxymethamphetamine (MDMA)-assisted psychotherapy have received Food and Drug Administration ‘breakthrough therapy’ designation for the treatment of resistant MDD and PTSD, respectively. This paper reviews the therapeutic rationale of both psilocybin and MDMA for treating both trauma-related MDD and PTSD.
Hospital Board of Directors’ Composition and Financial Performance: Empirical Evidence from Taiwan

The board of directors of a nonprofit proprietary hospital is responsible for supervising and managing major operational matters and reviewing operational results. This study investigates how hospital financial performance is influenced by director and supervisor characteristics among the board members of nonprofit proprietary hospitals in Taiwan. Data were obtained from the Division of Medical Services of the Ministry of Health and Welfare. A generalized linear model was used to evaluate 32 non-profit proprietary hospitals for the years 2006 to 2017, totaling 363 observations. The empirical results revealed a significant positive correlation between the proportion of directors with management qualifications and hospital financial performance. Moreover, the results represented that a higher proportion of board members with a medical background did not correspond to higher hospital financial performance. Although doctors accounted for the highest proportion of board members, indicating their key role in hospital management, the need for board members with management expertise cannot be ignored. Therefore, a balance between directors with management experience and medical knowledge on the board of directors is beneficial for hospital financial performance.
Effects of regular exercise on inflammasome activation-related inflammatory cytokine levels in older adults: a systematic review and meta-analysis

ABSTRACT Exercise has been found to play important roles in regulating inflammation, although the mechanisms are unclear. The present systematic review and meta-analysis aimed to investigate whether regular exercise could regulate inflammation through inflammasome activation signalling in older adults. Five databases were searched, and 19 randomised controlled trials (RCTs) studying effects of regular exercise on inflammasome activation-related inflammatory cytokines interleukin (IL)-1β and IL-18 and other key molecules involved in inflammasome activation signalling such as NOD-like receptor family pyrin domain containing 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), caspase-1 in older adults aged 50 years or older were included. The results showed that regular exercise could significantly decrease the levels of IL-1β and IL-18, important end-products of inflammasome activation in older adults. Subgroup analyses showed that aerobic exercise is the most effective training modality, and low-to-moderate intensity and mixed intensity are better compared with high intensity to decrease IL-1β and IL-18. The effect of regular exercise on key molecules involved in inflammasome activation signalling including NLRP3, ASC and caspase-1 is understudied and needs to be further investigated. These findings demonstrate that regular exercise could effectively decrease inflammasome activation-related inflammatory cytokine levels in older adults.
RETRACTED: Conservative oxygen supplementation versus usual oxygen supplementation among septic medical intensive care units patients: A before-after investigation

Patients admitted in the intensive care unit (ICU) are always managed with excessive high fraction of inspired oxygen and have hyperoxia for a significant period of time, which has potential harms. The guidelines for the management of patients in ICUs do not provide the target values for partial pressure of oxygen or arterial oxyhemoglobin saturations. The study was a before-after investigation comparing two time periods in which different oxygenation strategies were applied. Data of oxygen control, outcome measures, and mortality of a total of 273 patients (>18 years) admitted at least for 2 days in ICUs and received treatment for the sepsis were retrospectively collected and analyzed. Patients were received usual oxygen supplementation (targeted partial pressure of oxygen: 150 mmHg; a high fraction of inspired oxygen: 0.4; UOS cohort; n = 142) or conservative oxygen supplementation (targeted partial pressure of oxygen: 70–100 mmHg; a high fraction of inspired oxygen as low as possible; COS cohort; n = 131). Mechanical ventilation-free hours were significantly higher for patients of COS cohort than those of UOS cohort (77.99 ± 21.26 h/patient vs 70.01 ± 23.57 h/patient, p = 0.016). ICUs length of stays of patients of COS cohort was fewer than those of UOS cohort (7.05 ± 2.13 days/patient vs 7.69 ± 2.43 days/patients, p = 0.016). The probability of survival of patients was higher among patients of COS cohort than those of UOS cohort (p = 0.049). A higher number of patients from UOS cohort needed vasopressors than those from COS cohort (55 vs 35, p = 0.039). Conservative oxygen supplementation to maintain partial pressure of oxygen was improved outcome measures and decreases mortality as compared to that of usual oxygen supplementation. Level of Evidence: III. Technical Efficacy Stage: 4.