Miracle-dz/UniFAR-FTUs huggingface dataset:
Combining a sensor software with statistical analysis for modeling vine water de cit impact on grape quality

This work proposes a methodology using temporal data and domain knowledge in order to analyze a complex agronomical feature, namely the in uence of vine water de cit on grape quality. Raw temporal data are available but they are not directly usable to estimate vine water de cit. The methodology associates advanced techniques in computer science and statistics. A preliminary step is required to determine if the amount of water e ectively used by the vine is su cient or not. This step necessitates an ecophysiological model, based on expertise. The expertise is rst formalized in an ontology, under the form of concepts and relationships between them, and then used in conjunction with raw data and mathematical models to design a software sensor. Next the software sensor outputs are put in relation to product quality, assessed by quantitative measurements. This relation is analyzed by regression trees and advanced data analysis methods, such as functional data regression. The methodology is applied to a case study involving an experimental design in French vineyards. The temporal data consist of sap Email address: bch@supagro.inra. fr (Brigitte Charnomordic) Preprint submitted to Computer and Electronics in AgricultureTuesday 10 December, 2013 ow measurements, and the goal is to explain fruit quality parameters (sugar concentration and weight), using vine's water variations at key stages of vine phenological development. The results are discussed, as well as the method genericity and robustness.
The laminin proteins form one of the major networks within basement membranes and are required during development. Five laminin α, three laminin βand three laminin γsubunits are known in vertebrates and over 12 heterotrimeric laminin

The laminin proteins form one of the major networks within basement membranes and are required during development. Five laminin α, three laminin βand three laminin γsubunits are known in vertebrates and over 12 heterotrimeric laminin isoforms are thought to be assembled (Burgeson et al., 1994; Iivanainen et al., 1995; Miner et al., 1995). In vertebrates and invertebrates, laminin isoforms are widely distributed and a variety of phenotypes have been associated with the disruption of different laminins. For example, laminin α 2 mutations are found in some congenital muscular dystrophies (HelblingLeclerc et al., 1995; Sunada et al., 1994; Xu et al., 1994); laminin α3, β3 or γ2 mutations are found in junctional epidermolysis bullosa, a skin blistering disease (Aberdam et al., 1994; Kuster et al., 1997; McGrath et al., 1995); and mutations of the laminin β 2 chain gene disrupts neuromuscular and renal function (Noakes et al., 1995). Multiple defects are observed in mice that lack the laminin α 5 chain and the animals arrest late in embryogenesis (Miner et al., 1998). Mutations in zebrafish indicate that laminin β and γ subunits are important for notochord development (Parsons et al., 2002). In Drosophila, the two laminin αsubunits are required for embryonic viability; mutants have defects in the morphogenesis of heart, somatic muscle and trachea (Henchcliffe et al., 1993; Martin et al., 1999; Yarnitzky and Volk, 1995). Furthermore, there is evidence that one of the Drosophila laminin α subunits is required for the follicle cell/oocyte signaling that establishes the anteroposterior axis of the organism (Deng and Ruohola-Baker, 2000). Although genetic studies have established the diversity and complexity of laminin functions in vivo, the manner by which laminins mechanistically regulate development is not well understood. Traditionally, laminin and basement membranes have been viewed at substrates that support cell adhesion and migration. However, the idea that the supramolecular organization of laminin itself has an instructive role has gained support (Colognato and Yurchenco, 2000). On the surface of 3343 Development 130, 3343-3358 © 2003 The Company of Biologists Ltd doi:10.1242/dev.00481
Do and genotypes influence the plasma concentration and clinical outcome of donepezil treatment?

Purpose: Aim of our study was to evaluate the impact of CYP3A4, CYP3A5 and ABCB1 polymorphisms on donepezil disposition and clinical outcome. Methods: Fifty-four Italian patients diagnosed with probable mild to moderate Alzheimer’s disease, treated with donepezil (37 patients 5 mg/day, 17 patients 10 mg/day) were genotyped for CYP3A4 (*1B, *3 and *4), CYP3A5 (*2, *3 and *6) and ABCB1 (3435C>T, 2677G>T/A and 1236C>T) polymorphisms. All patients were evaluated for the degree of cognitive impairment with Mini Mental State Examination (MMSE) screening test at baseline (before treatment) and after at least three months of donepezil treatment at stable dose, when the drug plasma levels were measured. Results: Three patients carried one detrimental CYP3A4 allelic variant, and 12 one functional CYP3A5*1 allele. No statistically significant association was found between CYP3A4 or CYP3A5 genotypes and plasma donepezil concentrations, or between genotypes and clinical response (as measured by change in MMSE score). Nine ABCB1 haplotypes were observed, the most common being 1236C/2677G/3435C (46%) and 1236T/2677T/3435T (41%). Patients homozygous for the T/T/T haplotype had slightly though not significantly lower plasma donepezil concentration to dose ratios than those carrying other genotypes (median (95% CI) 0.18 (0.13-0.45) vs 0.31 (0.30-0.44) mg/l/mg/kg respectively). These patients also showed a slightly better clinical response (as measured by change in MMSE score) than the other genotype groups (median (95% CI) 0 (-1.3-3.3) vs -1.0 (-2.1-0.0), respectively). Conclusions: Our data suggest that the CYP3A4 and CYP3A5 polymorphisms are unlikely to influence donepezil metabolism and/or clinical outcome. On the other hand the ABCB1 polymorphisms may play a role in donepezil disposition and clinical outcome.
American Based Research Journal Vol-8-Issue-11 Nov-2019 ISSN (2304-7151)

Due to long-standing reliance upon negative, fear-based appeals in road safety advertising, this study attempts to examine the effectiveness of threat appeals in persuading Emirati road users to change their attitudes and behaviour in the short and long run. To measure the effectiveness of the threat advertising message, a quasi-experiment was designed, including two groups of Emirati students. Each group is composed of 100 Emirati students selected from two universities. Students were asked to complete a questionnaire at varying time intervals.as the persuasive effects of an advertising message may vary over time. On the other hand, 6 focus groups were constituted. Seven issues related to the impact of road safety ads on young Emiratis were raised and discussed and students proposed a number of suggestions that could help in making road safety awareness more efficient. The findings showed that road safety ads based on threat appeals have positive effects in the short term, but these effects diminish over time. Evidence suggests that threat appeals may influence females rather than males, despite the fact that many of these messages intend to target male road users
Novel Mechanism for the Control of Optimal Colocalization of TCR and CD8 as a

The improved efﬁcacy of high avidity CTL for clearance of virus has been well-documented. Thus, elucidation of the mechanisms that confer the increased sensitivity to peptide ligand demonstrated by high avidity CTL is critical. Using CTL lines of high and low avidity generated from a TCR transgenic mouse, we have found that functional avidity can be controlled by the expression of CD8 (cid:1)(cid:1) vs CD8 (cid:1)(cid:2) and the ability of CTLs to colocalize the TCR and CD8 in the membrane. Colocalization of these molecules was mediated by lipid rafts and importantly, raft disruption resulted in the conversion of high avidity CTL into a lower functional avidity phenotype. These novel ﬁndings provide insights into the control of functional avidity in response to viral infection. The Journal of Immunology, 2002, 169: 3492–3498.
WHAT ABOUT THE WOMEN? RAISING THE PROFILE OF FEMALE ENTREPRENEURS

The role of entrepreneurs has been raised within education circles (Davies, 2002), is covered in the media and is one of the focal points of the current government (Nicholson, 1998). Does this profile-raising of entrepreneurs cover all entrepreneurs or only a section? This paper sets out to investigate female entrepreneurship. Could it be that only men are born with the entrepreneurial drive and Ms Roddick is a genetic exception; or could it be that entrepreneurs are made, but women do not fit the mould? According to the song, “behind every great man, there has to be a great woman” (Lennox, 1985), are then potential female entrepreneurs suppressing their drive in order to support their husbands’ careers? Or are the “sisters doin’ it for themselves” (Lennox, 1985) but just not being recognised for doing so? This paper is not intended as a feminist diatribe, nor a veneration of ‘girl power’, but it does set out to investigate the potential for female entrepreneurship, together with its’ incidence in wider society. Reflecting upon current theoretical perspectives regarding entrepreneurial creation and/or development, the existence and opportunities for female entrepreneurs are investigated. A disparity was identified between that of US and UK women entrepreneurs, citing clear differences between recognition and typology of male and female entrepreneurs (McManus, 2000), although a distinct lack of empirical evidence exists regarding female entrepreneurship. Gender differences alone did not explain the reasons for differing rates of entrepreneurship, nor did the existence of a ‘glass ceiling’ (Fryer, 1997) or other discriminatory factors (Brindley and Ritchie, 1999). In addition, differences between male and female entrepreneurs were highlighted (Deakins, 1999) which agreed with the work by Cromie and Hayes (1988). As such, the recommendations of this paper are for a greater empirical analysis of female entrepreneurs incorporating all of Rees’ 1992 definitions due to the gender differences which exist. In addition, a strategy for the raising of the recognition of female entrepreneurs in wider society is proposed within the paper – identifying the need and potential routes for the amplified recognition of female entrepreneurs. This aims to ‘break’ some of the panes of both the glass ceiling and the ‘greenhouse’ which provides the pressure on recognised female entrepreneurs.
Delft University of Technology Architectural design education in varietate unitas

A fascinating and rich landscape of personal views and approaches can be seen in architectural design and in architectural design education. This variation may be confusing for students. This paper focuses on the question: is the framework of generic elements that we developed for explicating the design process helpful to compare the differences in architectural design approaches? The results of interviewing a variety of 15 architectural, urban and landscape designers show all kinds of personal approaches that have a set of five underlying generic elements in common. Therefore, the framework may be helpful for teachers and students to describe these personal approaches and may help students in understanding differences and similarities and in finding out what their own personal approach may be.
RMHP_A_310295 2453..2463

1Department of Health Statistics, School of Public Health, Shanxi Medical University, Taiyuan, People’s Republic of China; 2Department of Epidemiology and Biostatistics, Xuzhou Medical University, Xuzhou, People’s Republic of China; 3Shanxi Provincial Key Laboratory of Major Diseases Risk Assessment, Shanxi Medical University, Taiyuan, People's Republic of China; 4Department of Cardiology, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China Purpose: This study sought to develop models with good identification for adverse outcomes in patients with heart failure (HF) and find strong factors that affect prognosis. Patients and Methods: A total of 5004 qualifying cases were selected, among which 498 cases had adverse outcomes and 4506 cases were discharged after improvement. The study subjects were hospitalized patients diagnosed with HF from a regional cardiovascular hospital and the cardiology department of a medical university hospital in Shanxi Province of China between January 2014 and June 2019. Synthesizing minority oversampling technology combined with edited nearest neighbors (SMOTE+ENN) was used to pre-process unbalanced data. Traditional logistic regression (LR), k-nearest neighbor (KNN), support vector machine (SVM), random forest (RF), and extreme gradient boosting (XGBoost) were used to build risk identification models, and each model was repeated 100 times. Model discrimination and calibration were estimated using F1-score, the area under the receiveroperating characteristic curve (AUROC), and Brier score. The best performing of the five models was used to identify the risk of adverse outcomes and evaluate the influencing factors. Results: The SME-XGBoost was the best performing model with means of F1-score (0.3673, 95% confidence interval [CI]: 0.3633–0.3712), AUC (0.8010, CI: 0.7974–0.8046), and Brier score (0.1769, CI: 0.1748–0.1789). Age, N-terminal pronatriuretic peptide, pulmonary disease, etc. were the most significant factors of adverse outcomes in patients with HF. Conclusion: The combination of SMOTE+ENN and advanced machine learning methods effectively improved the discrimination efficacy of adverse outcomes in HF patients, accurately stratified patients at risk of adverse outcomes, and found the top factors of adverse outcomes. These models and factors emphasize the importance of health status data in determining adverse outcomes in patients with HF.
THERAPEUTIC POTENTIAL OF CANNABIS

Medical marijuana use is controversial in the American society. While the states move to legalize marijuana for medical or recreational use, research is needed to elucidate the adverse effects and potential therapeutic benefits of marijuana therapy. This review provides the current information on potential indications, pharmacology, toxicity, and contraindications for medical cannabis. Understanding of the potential uses of cannabinoids in various medical conditions will benefit the patients and healthcare providers. Legalization of marijuana use in 21 states of the US and the district of Columbia has called attention for health care providers.
Smart Data Recognition System For Seven Segment LED Display

An automatic data capturing system gives an alternative and effective way of data collection instead of manual data collection in the laboratory especially for the experiment that needs to be carrying out in a long period of time. It is able to solve the common mistakes made by human like misread or mistype the data. Thus, a new smart data recognition system for seven segment LED display is developed to make the whole process of data collection more systematic and accurate. An image is captured and saved automatically in an image file, and then it is processed through MATLAB software to identify the digits displayed on the LED display. Once the image is pre-processed, image analyzed, and image recognized, the final output values obtained are transferred to the exciting Excel file for further process depends on the user.
Oxidation Experiment of Coal Spontaneous Combustion Model Compounds

Coal spontaneous combustion causes huge losses in the process of coal mining and transportation. It is significant to research the mechanism of coal spontaneous combustion. Researchers have proposed theories about coal spontaneous combustion such as the bacterium-effect theory, pyrite-effect theory, phenyl-effect theory, coal-oxygen complex effect theory and free radical reactions theory, etc. Among all the theories, the coal-oxygen complex effect theory is widely agreed. However, its detail mechanism needs further studying. The model compounds are widely adopted for studying chemical reaction of complex system, such as the petroleum refining and the coal liquefaction. Benjamin once used more than 50 kinds of model compounds to study the bridge bonds crack in the coal liquefaction. Liu et al. selected methanol as model compound to study the effect of activator in bio-oil process. Because the molecule structures of the coal are complex and irregular, the experimental tests of spontaneous combustion are usually be disturbed and the existing research results of coal spontaneous combustion can not exactly describe the oxidation process of coal-surface-activate-groups. In order to Oxidation Experiment of Coal Spontaneous Combustion Model Compounds
Robust stability analysis for feedback systems with simultaneous uncertainties via IQCs

The robust stability of feedback interconnections is studied for a class of continuous-time causal linear systems over finite-energy signals of non-uniformly lower-bounded support. The stability of the feedback system with simultaneous uncertainties in the plant and the controller is exploited via integral quadratic constraints (IQCs), in which the plants and controllers are taken from two path-connected uncertainty sets with respect to the Feintuch's time-varying gap metric. Subsequently, the robust stability of the two-port networked system is characterised by means of the combination of IQCs and the time-varying gap. In particular, some robust stability criteria are applicable to the linear systems that do not have strong graph representations.
Minimum Wage in Mexico

This paper presents using regressions. First, the Mexico ferent trends. The trends studied are: exponential, linear, logarithmic, polynomial, power and mo ing average. The model that is adjusted to real conditions of oped by regressions through the data analysis of 25 years from 1993 until figures shown, it is clearly observed respect to exponential, linear, logarithmic, gression Model of fourth order adjusted to real conditions of the Mexico paper.
COMPARISON OF EFFICACY AND SAFETY OF TWO ARTIFICIAL TEARS IN PATIENTS WITH MILD TO MODERATE DRY EYE SYMPTOMS: A RANDOMIZED, PARALLEL STUDY

Purpose: Artificial tears are commonly used for symptomatic treatment of dry eye disease (DED). We compared the efficacy and safety of two preservative-free lubricant eye drops; Osmodrops (carboxymethylcellulose 0.5%, glycerin 0.9%; Cipla Ltd.) and Optive TM (carboxymethyl cellulose 0.5%; Allergan Inc.) in patients with mild to moderate DED. Methods: In this prospective randomized study, patients with mild to moderate DED (Dry Eye severity level 2 as per Dry Eye Workshop [DEWS] II grading system) were randomized (1:1) to receive Osmodrops or Optive 4 times daily for the duration of 8 weeks. Efficacy outcomes included Ocular Surface Disease Index (OSDI), tear break-up time (TBUT), and corneal fluorescein staining. Safety outcomes included the number and frequency of adverse events (AE). Results: Out of 178 patients enrolled, 93 (52.25%) and 85 (47.75%) were randomized to receive Osmodrops and Optive eye drops, respectively. After 8 weeks, both groups demonstrated benefit in alleviating the ocular symptoms. The mean OSDI score significantly declined from baseline to weeks 4 and 8 in Osmodrops (69.00±11.27 to 44.89±8.17 and 24.29±8.06, p<0.001) and Optive (69.58±10.63 to 47.22±8.30 and 25.23±9.75, p<0.001) groups. There was no significant difference in OSDI scores between the groups at either of the study visits. Patients in both groups exhibited significant improvement in TBUT and corneal fluorescein staining scores at weeks 4 and 8 (p<0.001). No AEs were reported. Conclusions: Both eye drops were found to be effective in decreasing the OSDI score and improving the tear film stability in patients with mild to moderate dry eye symptoms.
Review Analyzer: An Opinion Mining Based System

: In the last decade there has been a tremendous increase in the use of internet. People are becoming more tech savvy and are using online reviews to compare products before buying them. The field of opinion mining is hence about to boom and a huge scope for exploration exists in this field. Now a days there are various sites that offer a comparison of various products. A new problem that arises is of Opinion spam , that is, people giving fake opinions in order to try and increase or decrease the popularity of a product. This paper tries to study the various algorithms found in multiple papers.
ROSAT observation of two supersoft sources in the Large Magellanic Cloud

We present the results of ROSAT observation of CAL 83 and the new discovered soft source RX J0527.8-6954 in the Large Magellanic Cloud (LMC). Both sources have remarkably similar spectra which can be described by black-body radiation. The best fit values of N H = (1-2) × 10 21 cm −2 clearly indicate a LMC membership for both sources. The sources exhibit black-body temperatures of kT bb = 20-40 eV and radiate at the Eddington limit or even beyond. These sources may represent a new class of bright low-mass X-ray binaries (LMXB) which could help to solve the millisecond pulsar birthrate problem
Work-Related Symptom and Injuries Among Vehicle Maintenance Worker: an Overview

Vehicle Maintenance workers involve a task that is performed infrequently and exceptional conditions mainly to inspect, maintain and repair. The overview looks at past research on vehicle maintenance worker associate injuries and symptoms that influence their health and work. The purpose of this paper is to illustrate the issues, gather information and statistics on type of injuries, illness or symptoms arise from maintenance vehicle work to provide an effective way of understanding its nature of work. Methods search of the scientific database and the internet using the following keyword; ‘Vehicle maintenance worker’, ‘mechanic workers’, with injuries, incident and disease. Further point out other risk factors that influence work-related symptom and injuries, the program suggested, ergonomic implementation as a further approach to solving the rising issues with regards to maintenance vehicle sector. This paper administers a good understanding of car maintenance and its work task. By this knowledge, more flexible approach and efficient prevention can be done as a platform in tackling down work-related disease and injuries.
Sewage reflects the distribution of human faecal <i><fc>L</fc>achnospiraceae</i>

Sandra L. McLellan,1* Ryan J. Newton,1 Jessica L. Vandewalle,1 Orin C. Shanks,2 Susan M. Huse,3,4 A. Murat Eren3 and Mitchell L. Sogin3 Great Lakes Water Institute, School of Freshwater Sciences, University of Wisconsin-Milwaukee, 600 E. Greenfield Ave, Milwaukee, WI 53204, USA. U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, 26 West Martin Luther King Drive, Cincinnati, OH 45268, USA. Josephine Bay Paul Center, Marine Biological Laboratory at Woods Hole, 7 MBL Street, Woods Hole, MA 02543, USA. Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Providence, RI 02912, USA.