Miracle-dz/UniFAR-FTUs huggingface dataset:
Photogrammetric Modeling of Linear Features with Generalized Point Photogrammetry

Most current digital photogrammetric workstations are based on feature points. Curved features are quite difficult to be modeled because they cannot be treated as feature points. The focus of the paper is on the photogrammetric modeling of space linear features. In general, lines and curves can be represented by a series of connected points, so called, generalized points in the paper. Different from all existing models, only one collinearity equation is used for each point on the linear curve, which makes the mathematical model very simple. Hereby, the key of generalized point photogrammetry is that all kinds of features are treated as generalized points to use either x or y collinearity equation. A significant difference between generalized point photogrammetry and conventional point photogrammetry is that image features are not necessarily exact conjugates. The exact conjugacy between image features and/or the correspondence between space and image feature are established during bundle block adjustment. Photogrammetric modeling of several space linear features is discussed. Sub-pixel precision has been achieved for both exterior orientation and 3D modeling of linear features, which verifies the correctness and effectiveness of the proposed approach.
Efficient estimation of linear functionals of a probability measure P with known marginal distributions

Suppose that P is the distribution of a pair of random variables (X, Y) on a product space X x V with known marginal distributions Px and Py. We study efficient estimation of functions 0(h) = fh dP for fixed h: X x Y -R under iid sampling of (X, Y) pairs from P and a regularity condition on P. Our proposed estimator is based on partitions of both X and \V and the modified minimum chi-square estimates of Deming and Stephan (1940). The asymptotic behavior of our estimator is governed by the projection on a certain sum subspace of L2(P), or equivalently by a pair of equations which we call the "ACE equations. "
Mysteries of the arc cathode spot: A retrospective glance

The properties and the behavior of arc spots on cathodes, especially in vacuum arcs-the purest form of electrical discharges-are most surprising and very difficult to comprehend and to disclose at first glance. Their experimental exploration and theoretical interpretation took several decades and the task is not yet completed, in spite of many efforts and much progress. It remains an exciting problem and a challenge for future physical investigations, mainly due to the highly complex nature of arc spot operation, which calls for joint endeavors of several disciplines of physics, mathematics, chemistry, and material science. The effort is justified also by the technical applications and their requirements. I point out as a personal view some of these characteristic problems in the understanding of arc spots without claim to completeness. The main issues discussed are the cathode as the decisive electrode for the existence of electrical discharges, comparison with the anode, the strange properties of vacuum arc spots, their relation to glow cathodes and high pressure arc cathodes, the necessarily limited parameter range of arc spots, the astonishing, and the miraculous interplay of very different processes in arc spots cooperating in such a way to implement all the conditions to enable vacuum arcs, the conditions within the expanding cathodic plasma cloud (only briefly discussed) and, finally, arc spots as complex thermodynamic systems and self-organizing dissipative structures.
Fractional Steffensen type inequalities

In this article, we state, prove and discuss new Steffensen type fractional inequalities involving fractional derivatives of Canavati, Riemann–Liouville and Caputo types. Finally, we define functionals as a difference between the right- and left-hand sides of the new fractional Steffensen type inequalities and obtain related analogous of the Lagrange and the Cauchy mean value theorems. Furthermore, exponential convexity is proven.
A training data augmentation approach using GAN for learning of tactile paving images

This paper discusses an approach to training data augmentation for identifying and detecting tactile paving (braille) blocks in image with machine learning. Image recognition system that assists the visually impaired is necessary to efficiently identify the guiding blocks in the image, and machine learning, represented by CNNs, etc., is considered effective for this purpose. However, it is labor intensive to collect a sufficient number of training images from the pedestrian’s perspective in various environments, and furthermore, if the number of training data is insufficient, the final identification performance of the entire system will be degraded. To solve these problems, this paper attempts to generate new training data from a small number of tactile paving images by GAN(Generative Adversarial Network), and demonstrates through evaluation experiments that adding generated images to training data can stabilize learning and improve the rate of correct answers.
Efficient Cryptographic Primitives for Non-Interactive Zero-Knowledge Proofs and Applications

Non-interactive zero-knowledge (NIZK) proofs have enjoyed much interest in cryptography since they were introduced more than twenty years ago by Blum et al. [BFM88]. While quite useful when designing modular cryptographic schemes, until recently NIZK could be realized efficiently only using certain heuristics. However, such heuristic schemes have been widely criticized. In this work we focus on designing schemes which avoid them. In [GS08], Groth and Sahai presented the first efficient (and currently the only) NIZK proof system in the standard model. The construction is based on bilinear maps and is limited to languages of certain satisfiable system of equations. Given this expressibility limitation of the system of equations, we are interested in cryptographic primitives that are “compatible” with it. Equipped with such primitives and the Groth-Sahai proof system, we show how to construct cryptographic schemes efficiently in a modular fashion. In this work, we describe properties required by any cryptographic scheme to mesh well with Groth-Sahai proofs. Towards this, we introduce the notion of “structure-preserving” cryptographic scheme. We present the first constant-size structure-preserving signature scheme for messages consisting of general bilinear group elements. This allows us (for the first time) to instantiate efficiently a modular construction of round-optimal blind signature based on the framework of Fischlin [Fis06]. Our structure-preserving homomorphic trapdoor commitment schemes yield the first efficient leakage-resilient signatures (in the bounded leakage model) which satisfy the standard security requirements and additionally tolerate any amount of leakage. Furthermore, we build a structure-preserving encryption scheme which satisfies the standard CCA security requirements. While resembling the notion of verifiable encryption, it provides better properties and yields the first efficient two-party protocol for joint ciphertext computation. Note that the efficient realization of such a protocol was not previously possible even using the heuristics mentioned above. Lastly, we revisit the notion of simulation extractability and define “true-simulation extractable” NIZK proofs. Although quite similar to the notion of simulation-sound extractable NIZK proofs, there is a subtle but rather important difference which makes it weaker and easier to instantiate efficiently. As it turns out, in many scenarios this new notion is sufficient.
Development of modern immunization agent against bovine papillomavirus type 1 infection based on BPV1 L1 recombinant protein

Bovine papillomavirus type 1 L1 protein was produced in a baculovirus expression system and purified as virus-like particles (VLPs) by affinity chromatography using lectins. The morphological integrity of VLPs was confirmed by electron microscopy. Differences between the two detected variants were deciphered by mass spectrometry of peptides (MALDI-TOF). Mice were immunized with purified VLPs in doses of 10, 25, or 50 μg in combination with 1% saponin and 15% alhydrogel per dose as adjuvants. Analysis of the humoral immune response revealed increased levels of specific antibodies detected 3 weeks after the first immunization in all groups of animals. This was further significantly increased by the booster applied 3 weeks after the first dose, with the best immune response in a group of mice immunized by the largest dose of antigen. BPV1 L1 VLPs purified by affinity chromatography using lectins could be used for prophylactic immunization in veterinary medicine.
Using a value chain framework for food safety assessment of edible offals in Nairobi, Kenya

Edible offals comprise those parts of the animal considered fit for human consumption apart from the skeletal muscle, fat and attached skin. Edible offals form an important source of affordable animal protein and a delicacy for the larger Kenyan market. The offals are mainly traded in the informal markets which supplies at least 80% of the domestic market and where hygiene levels are low. The Meat Control Act Chapter 356, Laws of Kenya (Revised 2012) requires that offals be obtained from an officially declared food animal that has been slaughtered in a licensed slaughterhouse and declared fit for human consumption. According to the Meat Control Act, slaughterhouses in Kenya are classified as either export or local. The latter is subdivided into categories A, B, and C depending on their daily capacity, land size and the area they are authorized to supply meat and meat products. Each export slaughterhouse, category A and B slaughterhouses require a minimum of three meat inspectors to carry out inspection of carcasses and offals. The Directorate of Veterinary Services is the main regulator in Kenya on matters concerning safety of meat at the slaughterhouses. The Director of Veterinary Services appoints meat inspectors and veterinary officers who are responsible for ascertaining the safety of meat and meat products from the slaughterhouses. The meat inspectors also verify that slaughter facilities, staff, processes and equipment conform to food safety requirements. Offals, like carcass meat, should be handled under utmost hygiene conditions to minimize contamination or excessive growth of microorganisms. The current practices in slaughterhouses is that each set of edible offals is packaged separately in either polythene bags, plastic containers, meat transport containers or carriers and dispatched to the market. In some instances, stomachs and intestines are packaged for dispatch together with the lungs and hearts for transportation to distances over 50 km in either refrigerated or non-refrigerated containers or carriers. Some of these practices could compromise the safety of the offals. In this paper, we review the challenges faced in maintaining safety of edible offals especially at the slaughterhouses, distributors and retailers level from regulators' point of view.
EXPERIMENTS OF WATER FORMATION ON WARM SILICATES

When dust grains have a higher temperature than they would have in dense clouds, and when H, H2, and O2 have a negligible residence time on grains, the formation of water should still be possible via the hydrogenation of OH and Eley–Rideal-type reactions. We determined that the OH desorption energy from an amorphous silicate surface is at least 143 meV (1656 K). This is 400 K higher than the value previously used in chemical models of the interstellar medium and is possibly as high as 410 meV (4760 K). This extends the temperature range for the efficient formation of water on grains from about 30 K to at least 50 K, and possibly over 100 K. We do not find evidence that water molecules leave the surface upon formation. Instead, through a thermal programmed desorption experiment, we find that water formed on the surface of an amorphous silicate desorbs at around 160 K. We also measured the cross-sections for the reaction of H and D with an O3 layer on an amorphous silicate surface at 50 K. The values of the cross-sections, σH = 1.6 ± 0.27 Å2 and σD = 0.94 ± 0.09 Å2, respectively, are smaller than the size of an O3 molecule, suggesting the reaction mechanism is more likely Eley–Rideal than hot-atom. Information obtained through these experiments should help theorists evaluate the relative contribution of water formation on warm grains versus in the gas phase.
Association of antihypertensive drugs with fracture and bone mineral density: A comprehensive drug-target Mendelian randomization study

Background Observational studies have investigated the associations between antihypertensive drugs and fracture risk as well as bone mineral density (BMD), but yielding controversial results. Methods In this study, a comprehensive drug-target Mendelian randomization (MR) analysis was conducted to systematically examine the associations between genetic proxies for eight common antihypertensive drugs and three bone health-related traits (fracture, total body BMD [TB-BMD], and estimated heel BMD [eBMD]). The main analysis used the inverse-variance weighted (IVW) method to estimate the causal effect. Multiple MR methods were also employed to test the robustness of the results. Results The genetic proxies for angiotensin receptor blockers (ARBs) were associated with a reduced risk of fracture (odds ratio [OR] = 0.67, 95% confidence interval [CI]: 0.54 to 0.84; P = 4.42 × 10-4; P-adjusted = 0.004), higher TB-BMD (β = 0.36, 95% CI: 0.11 to 0.61; P = 0.005; P-adjusted = 0.022), and higher eBMD (β = 0.30, 95% CI: 0.21 to 0.38; P = 3.59 × 10-12; P-adjusted = 6.55 × 10-11). Meanwhile, genetic proxies for calcium channel blockers (CCBs) were associated with an increased risk of fracture (OR = 1.07, 95% CI: 1.03 to 1.12; P = 0.002; P-adjusted = 0.013). Genetic proxies for potassium sparing diuretics (PSDs) showed negative associations with TB-BMD (β = -0.61, 95% CI: -0.88 to -0.33; P = 1.55 × 10-5; P-adjusted = 1.86 × 10-4). Genetic proxies for thiazide diuretics had positive associations with eBMD (β = 0.11, 95% CI: 0.03 to 0.18; P = 0.006; P-adjusted = 0.022). No significant heterogeneity or pleiotropy was identified. The results were consistent across different MR methods. Conclusions These findings suggest that genetic proxies for ARBs and thiazide diuretics may have a protective effect on bone health, while genetic proxies for CCBs and PSDs may have a negative effect.
Trauma-related guilt as a mediator between post-traumatic stress disorder and suicidal ideation

Background As a mental health issue, suicide is a growing global concern, with patients who have post-traumatic stress disorder (PTSD) being at particularly high risk. This study aimed to investigate whether the link between PTSD and suicidal ideation is mediated by trauma-related guilt. Methods Data were obtained from Wave 1, Time 1 (November 2016), and Time 2 (March 2017) of the National Survey for Stress and Health (NSSH) in Japan. The NSSH is an online longitudinal survey conducted on Japan’s national population aged 18 years and older. The cumulative response rate of the survey was 66.7% at Time 2. A total of 1,005 patients with PTSD were included for analyses. The severity of PTSD symptoms was assessed with PTSD DSM-5 Checklist, and the trauma-related guilt were assessed using the two subscales (hindsight-bias/responsibility and global guilt scale) of the trauma-related guilt inventory (TRGI). Suicidal ideation was evaluated using the suicidal ideation attributes scale (SIDAS). Pearson’s correlation was used to investigate the associations among PTSD symptoms, TRGI scores, and SIDAS scores. Causal mediation analysis was applied to evaluate the causal relationship between PTSD, trauma-related guilt, and suicidal ideation. Results Pearson’s correlation did not show patients’ age, gender, and household income significantly associated with SIDAS scores. On the other hand, severities of PTSD symptoms (r = 0.361, p < 0.001) and trauma-related guilt (r = 0.235, p < 0.001) were positively associated with SIDAS scores. After adjusting for age, gender, and household income, the mediation analysis revealed that trauma-related guilt significantly mediates the effects of PTSD symptoms on suicidal ideation. Conclusion Our results implied that trauma-related guilt may represent a critical link between PTSD and suicidal ideation, which may be a noteworthy target for therapeutic intervention.
RNA interference in cytochrome P450 monooxygenase (CYP) gene results in reduced insecticide resistance in Megalurothrips usitatus Bagnall

Genes of the cytochrome P450 (CYP450) superfamily are known to be involved in the evolution of insecticide resistance. In this study, the transcriptomes of two Megalurothrips usitatus Bagnall (Thysanoptera: Thripidae) strains (resistant and susceptible) were screened for detoxification genes. MusiDN2722 encodes a protein composed of 504 amino acid residues with a relative molecular mass of 57.3 kDa. Multiple sequence alignment and phylogenetic analysis showed that MusiDN2722 is a member of the CYP450 family and has characteristics of the conserved CYP6 domain shared by typical CYP450 family members. RT-qPCR (real-time quantitative polymerase chain reaction) analysis showed that MusiDN2722 was upregulated in the acetamiprid-resistant strain compared with the susceptible strain (p < 0.05), and the relative expression level was significantly higher at 48 h after exposure than at 24 h after exposure. The interference efficiency of the injection method was higher than that of the membrane-feeding method. Silencing of MusiDN2722 through RNA interference significantly increased the sensitivity of M. usitatus to acetamiprid. Overall, this study revealed that MusiDN2722 plays a crucial role in the resistance of M. usitatus to acetamiprid. The findings will not only advance our understanding of the role of P450s in insecticide resistance but also provide a potential target for the sustainable control of destructive pests such as thrips.
Assessing milk products quality, safety, and influencing factors along the dairy value chain in eastern Democratic Republic of the Congo

Dairying is one of the new promising economic sectors in eastern Democratic Republic of Congo (DRC), but still not explored enough to ensure consumers' safety. This study aimed to assess the health risks and nutritional profile of milk products along the value chain in South-Kivu and Tanganyika provinces. A total of 288 milk actors, including 160 producers, 35 collectors and 93 vendors, were concerned for interview and milk samples collection. A total of 302 milk samples (159 raw, 44 pasteurized, 76 fermented and 19 white cheese so-called “Mashanza”) were collected for physicochemical [pH, fat, non-fat dry matter (NFDM), lactose, protein, freezing point, density] and microbiological (total Aerobic Mesophilic Flora, Escherichia coli, Total Coliforms, Fecal Coliforms, Salmonella and Staphylococci) analyses. Results revealed that the physicochemical characteristics of the milk mostly varied according to the type of milk and the regions. The pasteurized milk from Tanganyika presented the best physicochemical parameters [crude protein (CP) = 4.36%, Fat = 4.06%, NFDM = 12%, lactose = 5.4%, density = 1.02 and pH = 6.59] compared to other types of milk. For microbiology, no E. coli was recorded but Salmonella and Staphylococci were found in all the milk types with the values not exceeding 3 × 104 CFU ml−1 and 3 × 103 CFU ml−1, respectively. This implies a long-term consumers' health issue if appropriate measures are not taken by milk actors along the value chain. The microbiological quality was influenced by the ecologies of production axis (representing the production zones) and by handling methods and infrastructures used by the actors involved along the value chain. Factors related to animal husbandry, milking method, milk processing and packaging had no significant effect on the physicochemical parameters under study. These results indicated that health risks for milk consumers are accrued by production practices and handling by milk actors due to shortage of required skills and appropriate equipment along the milk value chain. Observance of hazard analysis critical control point (HACCP) measures is carefully required along the milk value chain nodes to improve the quality of milk produced and sold and thus reduce the risks among consumers in South-Kivu and Tanganyika provinces.
Antimicrobial peptides´ immune modulation role in intracellular bacterial infection

Intracellular bacteria cause a wide range of diseases, and their intracellular lifestyle makes infections difficult to resolve. Furthermore, standard therapy antibiotics are often unable to eliminate the infection because they have poor cellular uptake and do not reach the concentrations needed to kill bacteria. In this context, antimicrobial peptides (AMPs) are a promising therapeutic approach. AMPs are short cationic peptides. They are essential components of the innate immune response and important candidates for therapy due to their bactericidal properties and ability to modulate host immune responses. AMPs control infections through their diverse immunomodulatory effects stimulating and/or boosting immune responses. This review focuses on AMPs described to treat intracellular bacterial infections and the known immune mechanisms they influence.
Endothelial activation impairs the function of small extracellular vesicles

Small extracellular vesicles are nanosized vesicles (30–200 nm) that can ferry proteins, nucleic acids, and lipids between cells and therefore, have significant potential as biomarkers, drug delivery tools or therapeutic agents. SEVs of endothelial origin have been shown to -among other functions-reduce in vitro ischemia/reperfusion (I/R) injury in cardiomyocytes, but whether a pro-inflammatory state of the endothelium impairs the functionality of these SEVs remains to be elucidated. To test this, human umbilical vein endothelial cells cells were treated with TNF-α 10 ng/mL and the expression of the pro-inflammatory parameters VCAM-1, ICAM-1 and eNOS were determined by Western blot. SEVs were isolated from endothelial cells treated with or without TNF-α 10 ng/mL using size exclusion chromatography. The size and concentration of SEVs was measured by Nanoparticle Tracking Analysis. The expression of the surface marker CD81 was determined by immunoassay, whereas their morphology was assessed by electron microscopy. The function of endothelial SEVs was assessed by evaluating their cardioprotective effect in an ex vivo model of global I/R using isolated hearts from adult C57BL/6 mice. Treatment of HUVECs with TNF-α induced the expression of VCAM-1 and ICAM-1, whereas eNOS levels were decreased. TNF-α did not affect the production, size, morphology, or expression of CD81. SEVs significantly reduced the infarct size as compared with untreated mice hearts, but SEVs isolated from TNF-α treated cells were unable to achieve this effect. Therefore, a pro-inflammatory state induced by TNF-α does not alter the production of endothelial SEVs but impairs their function in the setting of I/R injury.