Miracle-dz/UniFAR-FTUs huggingface dataset:
Thioredoxin interacting protein (TXNIP) is an independent risk stratifier for breast ductal carcinoma in situ. Modern Pathology . ISSN 1530-0285

: Current clinicopathological parameters are useful predictors of breast ductal carcinoma in situ behaviour, but they are insufficient to define high risk patients for disease progression precisely. Thioredoxin interacting protein (TXNIP) is a key player of oxidative stress. This study aims to evaluate the role of TXNIP as a predictor of ductal carcinoma in situ progression. Tissue microarrays from 776 pure ductal carcinoma in situ and 239 mixed ductal carcinoma in situ and invasive tumors were constructed. All patients were treated at a single institution with a long-term follow-up and TXNIP expression was assessed using immunohistochemistry. TXNIP expression was investigated in terms of associations with clinicopathological and molecular features and patient outcome. Loss/reduced cytoplasmic expression of TXNIP was associated with features of aggressiveness including high nuclear grade ( p =1.6x10 -5 ), presence of comedo necrosis ( p =0.001) and oestrogen receptor negative (ER-)/HER2- ductal carcinoma in situ ( p =4.6x10 -5 ). Univariate analysis showed an inverse association between TXNIP expression and outcome in terms of shorter local recurrence free survival ( p =0.009). Multivariable analyses showed that independent predictors of ductal carcinoma in situ recurrence were low TXNIP expression ( p =0.005, HR=0.51 and 95%CI: 0.32-0.81), larger ductal carcinoma in situ size and high nuclear grade. TXNIP functions as a tumor suppressor gene with loss of its expression associated with ductal carcinoma in situ recurrence. TXNIP can be used as a potentially useful marker in prognostic stratification of ductal carcinoma in situ for management decisions. categorical (Chi-squared p for pure vs in situ and p <0.001 for ductal carcinoma in situ vs No expression was seen in cells of cases local recurrence free TXNIP
ARE CORPORATIONS STRATEGIC IN THEIR PHILANTHROPIC PRACTICES?

This paper examines the diversity of corporate philanthropic practices and aims to determine whether corporations are strategic in their philanthropic giving. Using an original database including firm-level data on dollar donations for charitable purposes among American Fortune 500 companies, this paper looks at the kind of firms that participate in giving, the kind of giving programs these firms set up, and the structure of the foundation giving these firms chose. The definition and identification of strategic philanthropy is discussed and explored. The main empirical findings of this paper provide evidence that at present time firms continue practicing non-strategic philanthropy.
MEASUREMENT AND ANALYSIS OF THE ANNUAL HEAT BUDGET FOR THE SEDIMENTS IN TWO WISCONSIN LAKES<link href='#lno19691410115-note-0001'>1</link>

Temperature was measured in the water, bottom sediments, and bog surrounding Stewart’s Dark Lake and Tub Lake, Wisconsin, five times during 1965-1966. A thermal probe was used to penetrate to depths to 8 m into the bottom. In the deepest water of Stewart’s Dark Lake, with no seasonal temperature fluctuation, a steady-state thermal gradient (0.20%/m) was observed in the bottom sediments. Thermal conductivity of these gelatinous sediments was measured at 1.10 x lo-” cal cm/cm” sec’C; thus prescribing a steady-state heat flow of 2.1 x lO-‘j Cal/cm’ set or 66 Cal/cm2 year. The pattern of isotherms within the bottom sediments and bog demonstrates the importance of solar radiation and the effects of absorption and circulation within these lakes. Seasonal changes in isotherm patterns are similar for both lakes. Seasonal temperature fluctuations are largely damped at depths below 4 m in the surrounding bogs. There is a negative (into the sediments) steady-state thermal gradient associated with the shoreline, but the gradient becomes positive lakeward and landward. Thus, with respect to mean sediment temperatures, each lake is surrounded by a relatively warm rim. The annual heat budget of the sediments at the shoreline in Tub Lake was 3,670 cal/cm2; at a water depth of 8 m, it was 70 cal/cm2. The mean annual budget for the entire sediments of Stewart’s Dark Lake was 730 Cal/cm2 and for Tub Lake was 970 cal/cm2. These values represent about 10 and 12%, respectively, of the total annual heat budgets for the water in each lake. The heat budget of the sediments is dependent on the amplitude of temperature variations of the overlying water and the thermal properties of the sediment.
Comparative Evaluation of Input Features Used for Deep Neural Networks to Recognize Semantic Indoor Scene from Time-Series Images Obtained Using Mobile Robot

—Human living indoor environments are changing continuously according to our various lifestyles and activities. Human-symbiotic robots require advanced capabilities of environmental understanding and adaptation. For robotic environmental adaptation, numerous machine-learning-based approaches have been proposed. Moreover, numerous types of features such as brightness, edges, texture, etc. have been used for learning networks. This study was conducted to evaluate combinations of supervised-learning-based indoor scene recognition methods and their input features. This paper presents a framework to provide image features of three types according to learning strategies. The experimentally obtained results evaluate using two open benchmark datasets revealed suitable combinations of input features including weights obtained from category maps of Counter Propagation Networks (CNNs) used for Deep Neural Networks (DNNs). We demonstrate a suitable combination of features from scene images used for semantic indoor scene recognition. Particularly, higher recognition accuracy is obtain-able using original time-series images for learning with CNNs.
Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in 1 Humans 2 3

1) Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center 6 Munich at the University of Tübingen, Tübingen, Germany 7 2) German Center for Diabetes Research (DZD e. V.), Tübingen, Germany 8 3) Department of Internal Medicine IV, University of Tübingen, Germany 9 4) Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, 10 Germany 11 5) Department Pharmacy and Biochemistry, Faculty of Science, Eberhard Karls 12 Universität Tübingen, Tübingen, Germany 13 14
Detection of Misbehaving Nodes in Mobile Ad hoc Network

— Mobile Ad-hoc Network (MANET) is an indivisible part for communication of mobile devices. It is a dynamic wireless network that can be formed without any pre existing infrastructure in which each node can act as a router. It is easy to deploy node failure and network traffic to impersonate another node in MANET. Mobile ad hoc network has no clear line of defense, so, it is accessible to both legitimate network users and misbehaviors. In the presence of misbehaviors, one of the main challenges is to design the trust reputation system that can protect MANET from various misbehaviors. The main objective of the work is to detect the misbehavior using trust based mobility system. Mobility is exploited in order to detect the misbehavior. This model is carried out in two cases which exploit mobile nodes to collect and broadcast trust information to achieve trust convergence and provides the authentication to the mobile nodes in order to detect the misbehavior. Each node would evaluate its own trust vector parameters about neighbors through monitoring neighbor’s pattern of traffic in network. Simulation results shows that the mobility oriented trust system provides better detection efficiency, packet delivery ratio, low delay and good misbehaving node detection based on delay constraint.
Performance Evaluation of DSDV and AODV Protocols for Green Corridor Management in a Metropolitan City

—Air pollution is a serious health concern in densely populated metropolitan cities. congestion is a major challenge, especially in medical emergency cases, such as transportation of life saving drugs, accident victims, or transplant organs. In this paper, we propose a signal free corridor based air pollution management for ambulances by maintaining proper speed in which ambulances do not encounter any signals, decreasing the vehicle density and air pollution at junctions. Performance evaluation of Destination Sequenced Distance Vector Protocol (DSDV) and Ad-Hoc On Demand Distance Vector Protocol (AODV) for the vehicular environment in multiple scenarios has been simulated and the results are encouraging .
Disorders in

Background and aims : Musculoskeletal disorders and lack of mental health are two very important problems among employed people. The present study was conducted to compare the ROSA and RULA methods in risk assessment of catching to musculoskeletal disorders and to find the relationship with mental health on computer users. Methods : Present study was a descriptive - analytic cross-sectional study. 71 employees were selected from Isfahan University of Medical Sciences. Data collection was carried out in five stages as follows: 1) demographical data investigation 2) Prevalence investigation of musculoskeletal disorders with Nordic questionnaire, assessment of ergonomic factors risk in among employees using 3) ROSA method 4) RULA method 5) Evaluation of mental health. The collected data were analyzed by SPSS 20 software. Results : Assessment of staff body posture during work with two methods of ROSA and RULA had a direct and significant relationship (R=0.808 and p<0.001). Also, the final score of ROSA had a direct and significant relationship (R= 0.555 and p<0.001) with mental health of the staff. Conclusion : Given that two methods of ROSA and RULA have a direct and desirable correlation with each other, each of these two methods can be used interchangeably with great confidence. In addition, the increase risk of musculoskeletal disorders was associated with mental health reduction in the staff.
Regulation of Human UDP-Glucuronosyltransferase 2B15 and 2B17 by miR-376c in prostate cancer cell lines

Given the prime importance of UGT2B15 and UGT2B17 in inactivating testosterone and dihydrotestosterone, control of their expression and activity in the prostate is essential for androgen signalling homeostasis in that organ. Although several studies provide evidence of transcriptional control of UGT2B15 and UGT2B17 by various endogenous and exogenous compounds, potential post-transcriptional regulation of UGT2B15 and UGT2B17 by microRNAs in prostate cancer cells has not been examined. The present study identified a putative miR-376c target site in the 3’-untranslated regions (UTR) of both UGT2B15 and UGT2B17 mRNAs. In accord with the possibility that this miRNA negatively regulates UGT2B15 and UGT2B17 expression, there is an inverse correlation in the levels of miR-376c and UGT2B15/UGT2B17 mRNAs in prostate cancer cell lines versus normal prostate tissue. In LNCaP cells, transfection of miR-376c mimics inhibited the glucuronidations of testosterone, 4-methylumbelliferone (a substrate of UGT2B15) and androsterone (a substrate of UGT2B17). MiR-376c reduced both UGT2B15 and UGT2B17 mRNA and protein levels, and the activity of luciferase reporters containing UGT2B15 or UGT2B17 3’-UTRs. This microRNA-mediated repression was significantly abrogated by mutating the miR-376c binding site in the 3’-UTRs of both UGTs. Collectively, these data indicate that the expression of UGT2B15 and UGT2B17 is negatively regulated by the binding of miR-376c to the 3’-UTRs of UGT2B15 and UGT2B17 in prostate cancer cells. This represents the first evidence for post-transcriptional regulation of UGT2B15 and UGT2B17 by miRNAs in prostate cancer cells and may have importance in regulating androgen receptor signalling. predict potential miRNA target Using this the present study identified a potential miR-376c target site in the 3’-UTRs of both UGT2B15 and UGT2B17. We further demonstrated that this site mediates the down-regulation of both UGT2B15 and UGT2B17 expression by miR-376c. This represents the first evidence for post-transcriptional regulation of UGT2B15 and UGT2B17 by miRNAs in prostate cancer cells.
Sensing Amino Acids with Nanopore

Primary structure identification of peptides and proteins is essential for the advancement of proteomics, as it determines how these biopolymers fold and perform their biological function. Previous works found that, very often, even subtle changes in the primary sequence of a protein can cause debilitating pathologies [1]. Currently, the most common method for protein sequencing and proteomic analysis is mass spectrometry (MS), a technique that involves fractionating a protein into many smaller peptides and then obtaining the mass-to-charge ratio of each new peptide from the mass spectrometer [2]. However, known limitations affecting this method are: 1) low abundance of precursor peptide and poor fractionation efficiency; 2) The sensitivity varies among different analytes and between instrument models. For example, matrixassisted laser desorption/ionization-time of flight MS suffers from significant loss of sensitivity on samples with high concentration of salts; 3) Accurate sequencing becomes challenging with mass spectrometry in certain instances as some amino acids have similar mass and charges; 4) MS instruments are too expensive and sophisticated for broad application [3].
Part 3. Biotechnology and biology ANALYSIS Of SNPS F279Y AND S555G IN GROWTH HORmONE RECEPTOR GENE IN BEEf AND DAIRY CATTLE BREEDS

Summary. Effect of growth hormone on animal growth and metabolism is mediated by interaction with the specific receptor ( GHR ). Marker-assisted selection programs in cattle include SNPs in GHR gene regarding their association with fertility and lactation performance. The aim was to analyze the relation between SNPs F279Y and S555G in GHR gene with growth traits in Aberdeen-Angus and tp draw comparisons with beef and dairy cattle of other countries. SNP genotyping was performed with PCR-RFLP methods. Statistical methods included Pearson’s chi-squared test, Pearson’s correlation coefficient r and ANOVA. The allele and genotype frequencies of SNP F279Y ( rs385640152 ; g. 914T>A ) are: T — 0.69 and A — 0.31; TT — 62.1%, TA — 13.8% and AA — 24.1% (n = 58); SNP S555G ( rs109300983 ; g. 257A>G ) are: A — 0.86 and G — 0.14; AA — 73.1%, AG — 25.0% and GG — 1.9% (n = 58). Population is in Hardy-Weinberg equilibrium for S555G , contrary to F279Y . Animals with AA -genotype of SNP F279Y are characterized by the higher ADG (+40–100 g/day), as well as body weight at 8 month (+10–30 kg) and 2 years (up to +40 kg). In total dairy breeds group the frequency of T-allele in SNP F279Y negatively correlated with milk yield ( r=–0.713 ).
Preserving Confidentiality in Wireless Medical Data

In recent times, healthcare applications are widely being used for remote patient monitoring and in hospitals using wireless sensor networks. Wireless medical sensor networks are highly vulnerable to different kind of attacks such as eavesdropping, modification, data breach etc which is a potential threat to patient sensitive physiological data. Security for wireless medical sensor networks is one of the major requirements in order to attain few issues like authentication, integrity and confidentiality. A considerable measure of work has been done to secure wireless medical sensor networks. The existing healthcare solutions can protect information amid transmission but in any case fails to stop inside attack where the sensitive patient data will be revealed by the malicious database administrator. The proposed system presents a practical approach to overcome this issue by making use of multiple data servers for storing patient sensitive data. The primary contribution of this system is secure transmission of patient sensitive data to multiple data servers and performing statistical analysis on the patient data using Paillier cryptosystem and EIGamal cryptosystems by ensuring patients’ privacy.
S  C  I  L  H   I  S  S

In this paper, we investigate a class of screen conformal invariant lightlike hypersurfaces of an indeﬁnite Sasakian manifold. The geometric conﬁguration of such hypersurfaces is established. We prove that its geometry is closely related to the one of leaves of its conformal screen distributions. We also prove that, in any leaf of a conformal screen distribution of an invariant lightlike hypersurface of an indeﬁnite Sasakian space form, the parallelism and semi-parallelism notions are equivalent.
COMPARISON OF ANTIHYPERLIPIDAEMIC ACTIVITY OF EUGENIA JAMBOLANA FRUIT WITH PUNICA GRANATUM FRUIT IN DIET INDUCED HYPERLIPIDAEMIC RATS

Objective: To compare the antihyperlipidemic effects of Eugenia Jambolana fruit pulp with Punica Granatum fruit in diet induced hyperlipidaemic rats at the same dose level. Methods: An experimental randomized control study was conducted on seventy five male albino rats over a period of 14 weeks in University of Health Sciences Lahore. They were divided into five groups labelled A, B, C, D and E with fifteen rats in each group. Group A was kept as normal control, groups B, C, D and E were given hyperlipidaemic diet for six weeks. In group B no further intervention was done, group C and D were given ethanolic extract of Eugenia Jambolana and Punica Granatum respectively for eight weeks. Group E was given combination of both for same duration. Serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-c), lowdensity lipoprotein cholesterol (LDL-c) and triglycerides (TG) were measured at zero, six and fourteen weeks. Results : At fourteenth week significant reductions in TC, LDL-c and TG and a rise in HDL-c was observed in interventional groups C, D and E as compared to experimental hyperlipidaemic control group B ( p <0.05). There was no significant difference at baseline (zero weeks) serum TC, HDL-c, LDL-c and TG of groups A, B, C, D and E; p > 0.57, p > 0.22, p > 0.56, p > 0.76, respectively. On sixth week, there was no significant difference between groups B, C, D and E ( p > 0.05). However, 15 rats of group A had significant lower levels of cholesterol, high density lipoproteins, low density lipoproteins and triglycerides when compared to 60 rats of groups B, C, D and E ( p <0.05). Conclusion: In male albino rats combination of ethanolic extracts of Eugenia Jambolana and Punica Granatum fruit pulps was most effective in lowering serum total cholesterol and triglycerides while decrease in low density lipoprotein cholesterol and rise in high density lipoprotein cholesterol was same as the extracts given alone.
The role of heritage structural engineering and why it is important for future generations

Abstract This paper explores why heritage structural engineering is essential to our society and our future profession. Society has become consumer-driven, where the latest technology or fashion is more important than our understanding our history and how it has shaped us and where we are today. Our engineering heritage with some exceptions has suffered. Structures which are old and yet have many interesting or unique features and which could be reused are demolished to make way for a modern building. Similarly, our industrial heritage and equipment are neglected, or the site redeveloped for housing or similar without any thought to its history and its heritage and how it might be usefully retained for future use by society. From a sustainability point of view and reducing the carbon footprint, it is far more economical to reuse a building or structure than demolish it and at the same time can save significant costs. We are all responsible for preserving history, but in particular, all engineers have the responsibility for preserving the engineering masterpieces and our heritage for future generations. This paper examines what we need to do to train the younger structural engineers in the art of structural heritage engineering and why the history and conservation of structural engineering are so important for the future.
Availability Bias and the COVID-19 Pandemic: A Case Study of Legionella Pneumonia

Cognitive biases, such as the availability heuristic or availability bias, can inadvertently affect patient outcomes. These biases may be magnified during times of heightened awareness of a particular disease. Failure to identify cognitive biases when managing patients during the coronavirus disease 2019 (COVID-19) pandemic can delay the institution of the right treatment option and result in poor health outcomes. We present a case of delayed diagnosis of Legionella pneumonia due to COVID-19-related availability bias. We discuss some methods to mitigate the effects of this bias and the importance of challenging trainees to recognize these pitfalls in medical training.
Bupropion for Smoking Cessation in Patients With AMI Because persistent smoking after acute myocardial infarction

Results A total of 392 patients were randomized (mean age 53.9 10.3 years); 83.5% were male; 64.9% had STsegment elevation myocardial infarction). Patients smoked a mean of 23.2 10.6 cigarettes/day for a mean of 32.9 12.4 years. At 12 months, point prevalence abstinence rates were 37.2% in the bupropion group and 32.0% in the placebo group (p 0.33; % difference after adjusting for between center differences 3.9%). Continuous abstinence rates were 26.8% and 22.2%, respectively (p 0.34). Major adverse cardiac event rates were similar (13.0% vs. 11.0%, respectively; p 0.64).