Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring Preclinical Medical Students’ Reflections on their Learning Experience during the COVID-19 Pandemic

The coronavirus disease 2019 (COVID-19) pandemic has posed considerable challenges to higher education. To understand how the new landscape of curriculum delivery affects learning experience, a qualitative descriptive study was conducted among preclinical medical students in Universiti Sultan Zainal Abidin, Malaysia between March 2021 and April 2021. Data were collected using an online Padlet platform which included an open-ended question with additional guided questions whereby students wrote their reflective writings, describing their perceptions on how online learning due to the COVID-19 pandemic affected their education. All reflective writings were transcribed verbatim. Data were analysed based on an established framework of systematic, robust, and credible thematic synthesis. A total of six students provided their reflective writings. The analyses revealed four themes. ‘Adaptability and flexibility’ appeared as the prominent theme, followed by ‘reduced learning acuity’, ‘compromised tacit learning’, and ‘supports from policy and practice’. Students’ adaptability to the new educational practices is indispensable to harvest the advantage of being flexible with online-based learning. It was concluded that key strategies for quality online-based learning during the COVID-19 pandemic include educators’ training on engaging techniques, planning that avoids excessive and successive online classes, support for dedicated learning space at home, family engagement to reduce distractions, and students’ access to quality technological hardware and software. Engineering solutions for affordable and reliable Internet connectivity are the main policy issues. Finally, the study recommends long-term educational goals which should address the irreplaceable aspects of tacit learning that are lost when transitioning to online-based learning.
Phenotypic Selection in Halenia elliptica D. Don (Gentianaceae), an Alpine Biennial with Mixed Mating System

The transition from outcrossing to selfing is a common evolutionary trend in flowering plants, and floral traits change significantly with the evolution of selfing. Whether or not plant traits are subjected to selection remains an open question in species with mixed mating systems. We examined phenotypic selection in two populations of Halenia elliptica with different selfing rates. We found that the pollen–ovule ratio, seed size, plant height, spur length, and pollinator visitation rate in the population with the higher selfing rate were lower than those in the population with the lower selfing rate. Selfing provides reproductive assurance for populations when pollinator service is low, and the floral traits that are associated with selfing syndrome are evident in populations with a higher selfing rate but are subjected to weak selection in each of the two populations with different selfing rates. Directional selection for an early flowering time indicated that late blooming flowers could experience a risk of seed development in alpine environments, and for large plants, selection indicated that seed production could be limited by the available resources. The floral traits that are associated with pollinator attraction and specialization could be subjected to weak selection at the plant level as selfing evolves, and the selective pressures that are independent of pollinators might not change significantly; highlighting the selective biotic and abiotic pressures that shape the morphological traits of plant species and their independence from the mating system.
Utilización de videojuegos en la industria y en la educación

Los videojuegos son productos digitales que se vienen aplicando en diversos contextos que no son necesariamente lúdicos dado que contienen características que permiten la mejora de diversas habilidades de parte de los videojugadores. En el presente artículo se realiza una revisión de las tendencias en la aplicación de videojuegos en la industria y en la educación, tomando como marco el modelo MDA (Mechanics, Dynamics y Aesthetics), así como se revisan algunas definiciones de conceptos necesarios para el entendimiento y análisis de estos productos digitales. Al final, se concluye en la impor­tancia de los videojuegos por su capacidad de generar motivación y enfoque, por lo que su aplicación en entornos distintos a los de entretenimiento generaría muchos beneficios.
National Yearly Trend of Utilization and Procedural Complication of the Watchman Device in the United States

Background Complication from the Watchman device (Boston Scientific Corp, Marlborough, Massachusetts) is operator-dependent, with the latest EWOLUTION trial showing low complication rates (1.8%) thought to be due to maturing physician experience. Objectives The objective of this study is to understand the yearly trend of utilization and complication rates of the Watchman device in hospitalized patients. Methods The national inpatient sample (NIS) was queried for all hospitalization with primary atrial fibrillation or flutter from 2016 to 2019 with percutaneous left atrial appendage occlusion (LAAO). The frequency of peri-procedural complications, including death, stroke, major bleeding requiring blood transfusion, pericardial effusion, post-op hypotension, cardiac arrest, postprocedural CHF, implant displacement/leak, systemic embolism, and requiring repeat procedures, were assessed. Results From 2016 to 2019, an estimated 60,350 LAAO procedures were performed. The majority of the procedure was done in white (84.88%), males (58.40%), with a mean age of 76, at teaching hospitals (88.27%). Complication rates were around 5.72%, with no change from 2016 to 2019 (annual percentage change, APC: 6.23; p-value: 0.170) despite rapid increase in yearly utilization of Watchman from 1.12% in 2016 to 5.45% in 2019 (APC: 62.30; p-value of 0.013). Pericardial effusion (3.41%) was the most common complication, followed by bleeding requiring transfusion (1.40%) that had no significant change over time. Conclusion Our study demonstrates that trend of complications with the Watchman device implantation in the real-world practice didn’t improve over time, possibly due to characteristics inherent to the device and patient population. Hence, we expect a further drop in nationwide complication rates with the improved design of Watchman-FLX and increased placement experience.
Prediction of Solitary Plasmacytoma of Bone in Elderly Patients: A Nomogram and a Risk Classification System for Overall Survival

Background Solitary plasmacytoma of bone (SPB) is an isolated plasmacytoma of bone origin, most commonly seen in the elderly, with a poor prognosis. So far, there is no precise nomogram to predict the overall survival (OS) of elderly patients with SPB. Our goal is to construct and validate a nomogram for elderly patients with SPB. Methods This study collected all elderly patients with SPB in the Surveillance, Epidemiology and End Results (SEER) database from 2000 to 2018, and the variables included were age, sex, race, marital status, primary site, grade, stage, surgery, chemotherapy, and radiotherapy. Independent prognostic factors were identified using univariate and multivariate Cox analysis. The nomogram was constructed to predict 1-, 2-, and 3-year OS of elderly patients with SPB. The receiver-operating characteristic (ROC) and the calibration curves were used to differentiate and calibrate the nomogram. The clinical validity of the nomogram was evaluated by decision curve analysis (DCA). The total OS scores of all elderly SPB patients were calculated and divided into two risk subgroups for comparison. Results A total of 1837 patients diagnosed with SPB were screened from the SEER database, with a final inclusion of 1180 patients (age ≥ 60 years). Age, radiotherapy, and marital status were significantly correlated with OS. These characteristics were further incorporated into the creation of the nomogram for predicting 1-, 2-, and 3-year OS of elderly patients with SPB. For this predictive model, the area under the ROC curves, calibration curves, and DCA have good performance in terms of differentiation, consistency, and validity, respectively. In addition, patients in the high-risk group (≥96) had a worse prognosis than those in the low-risk group (<96). Conclusion We constructed a nomogram and a risk classification system that could provide an intuitive and effective tool for clinicians to better predict the OS of elderly SPB patients.
An iterative algorithm for the position of time-varying phase screens in the atmospheric turbulence

When considering the time-variant characteristics of atmospheric turbulence in the numerical simulation research, it is very essential to generate the phase screens that meet the requirement. Meanwhile, in the numerical simulation of light propagation along an inhomogeneous turbulent path, the reasonable position of phase screens is also very important. In this article, an iterative algorithm of phase screen position based on the multilayer model of phase screens is given. And the phase screens are also continuously interpolated in order to meet the need of dynamic movement. Moreover, an example of light propagation combining the time-variant phase screens in two-layer system is provided under condition of the Hufnagel-Valley5/7. Thereafter, the characteristics of the optical wavefront and intensity changed with time are analyzed. The results show that the statistical properties of the generated phase screen coincides well with theoretical model of atmospheric turbulence in the low and high frequency region which is mainly concerned. The variance of Zernike coefficients of the optical wavefront in numerical simulation agrees with theoretical values basically. Although there is certain error existence in the probability density distribution of intensity fluctuation between simulation results and theoretical analyses, the trend of it is consistent with the lognormal distribution. Thus, the feasibility and validity of the above mentioned iterative algorithm is vindicated.
The effect of risk on supply chain performance and operator performance: The case study of rice supply chains

Supply chain risks hinder the cooperation among members, negatively affecting the supply chain and enterprises’ performance. This study applies structural equation modeling (SEM) to demonstrate the relationship between risk, supply chain performance, and business performance in the Mekong Delta, Vietnam. Research data were collected from 142 rice enterprises. The result demonstrates that risks occurring in the supply chain negatively influenced the performance of the rice supply chain and the performance of rice enterprises. Besides, the study shows that rice supply chain performance positively impacts on rice business performance in the Mekong Delta, Vietnam.
Bar Load-Velocity Profile of Full Squat and Bench Press Exercises in Young Recreational Athletes

The purpose of this study was to determine the mean propulsive velocity (MVP) at various percentages of one repetition maximum (1RM) in the full squat and chest press exercises. A total of 96 young women and 256 young men (recreational athletes) performed an incremental test (50–60–70–80% 1RM) comprising the bench press and full squat exercises in two different sessions. The individual load and velocity ratios were established through the MPV. Data were analyzed using SPSS software version 25.0, with the significance level set at 5%. The following findings were revealed: highly linear load-velocity relationships in the group of women (r = 0.806 in the squat, and r = 0.872 in the bench press) and in the group of men (r = 0.832 and r = 0.880, respectively); significant differences (p < 0.001) in the MPV at 50–70–80% 1RM between the bench press and the full squat in men and at 70–80% 1RM in women; and a high variability in the MPV (11.49% to 22.63) in the bench press and full squat (11.58% to 25.15%) was observed in women and men (11.31% to 21.06%, and 9.26% to 24.2%) at the different percentages of 1RM evaluated. These results suggest that the load-velocity ratio in non-strength-trained subjects should be determined individually to more precisely establish the relative load to be used in a full squat and bench press training program.
Exploration of Art Education of Colleges and Universities under Covid-19 from the Perspective of Pragmatism

The paper is to discuss how "education is life", an idea put forward by Dewey, an American pragmatist philosopher and educator, is reflected in the art education in Chinese college and universities from the perspective of pragmatism Considering the fact the Covid-19 is sweeping all over the globe and there is no sign that the trend of this global pandemic is going to slow down, the paper is to find the relationship between art education and social life of the college and universities students under this background. The paper begins with an interpretation of the connotation of “Education is Life”, and then it gives reader a brief introduction of the perspective the paper adopts, Pragmatism. The main body of the paper discusses the opportunities and challenges of art education under the outbreak of the Covid-19. At the end of the paper, the author summarizes the enlightenment of art education, and puts forward that people-oriented teaching should be adopted to maintain the consistency between life and education. The study hopes to give readers some insights on the harmony development of art education under this unexpected global event.
A perspective on 21st design challenges facing the urgency of solutions for global sustainability

Before the accelerated transformation of reality, we question the human role in the technological context, placing the need of thinking about the importance of intrinsically human competences. In the scope of design, a field of practice and academic discipline, the challenge for the profession and the future education is huge. Above all, these challenges have to do with large scale and with processes requiring the ability to deal with more complex conceptual frameworks, with a set of context dimensions involving economic, ecological, social, cultural, and political issues of societies in permanent change. The design community recognizes the value of designer's multidisciplinary skills and the ability to lead processes involving large socio-technical systems. However, today the designer faces the challenge of multidisciplinary working teams where skills go far beyond their traditional abilities. The thinking and practice of design reveals a set of core values ​​and virtues of the designers that allows a strategic positioning of these professionals in the complex problem-solving context. Nevertheless, designers will have an increasingly demanding role in creating products, services and experiences which mean a profession under pressure to evolve towards a more complex activity requiring new general and specialized skills. The objective of our reflection is about designer’s competencies transition demand, an imperative requiring technological and management skills and leadership capacity on sustainable solutions complex processes. Despite this recognition, designers must be prepared about collaboration and cooperation skills, a necessity more and more in tension with a reality where the whole potential of design to deal with complexity remains unaware. Design community reflects about designer’s strategic value for facing global challenges and points out the complexity approach as a requirement of design education in the future. Considered a condition for design expansion this concern is also revealed in design education research contributions. This contextual disposition makes possible to regard an alignment about a direction to pursue. This paper presents a reflection about this problematic field which intends to be a contribution to understand how design discipline can evolve meeting the designer’s community recognition of the necessity of a set of updated critical dimensions for design activity. This reflection looks at the design community before a strong demand for an evolution, pushing to a design education deep transformation. This kind of evolution for design may occur first in the professional practice and will be primarily caused, in our perspective, by the desirable and the unavoidable impact on design processes of a design community's new mindset about core principles.
ATM Pathway Is Essential for HPV–Positive Human Cervical Cancer-Derived Cell Lines Viability and Proliferation

Infection with some mucosal human papillomavirus (HPV) types is the etiological cause of cervical cancer and of a significant fraction of vaginal, vulvar, anal, penile, and head and neck carcinomas. DNA repair machinery is essential for both HPV replication and tumor cells survival suggesting that cellular DNA repair machinery may play a dual role in HPV biology and pathogenesis. Here, we silenced genes involved in DNA Repair pathways to identify genes that are essential for the survival of HPV-transformed cells. We identified that inhibition of the ATM/CHK2/BRCA1 axis selectively affects the proliferation of cervical cancer-derived cell lines, without altering normal primary human keratinocytes (PHK) growth. Silencing or chemical inhibition of ATM/CHK2 reduced the clonogenic and proliferative capacity of cervical cancer-derived cells. Using PHK transduced with HPV16 oncogenes we observed that the effect of ATM/CHK2 silencing depends on the expression of the oncogene E6 and on its ability to induce p53 degradation. Our results show that inhibition of components of the ATM/CHK2 signaling axis reduces p53-deficient cells proliferation potential, suggesting the existence of a synthetic lethal association between CHK2 and p53. Altogether, we present evidence that synthetic lethality using ATM/CHK2 inhibitors can be exploited to treat cervical cancer and other HPV-associated tumors.
Use of Xenogenic Collagen Matrices in Peri-Implant Soft Tissue Volume Augmentation: A Critical Review on the Current Evidence and New Technique Presentation

Plastic peri-implant surgical procedures aiming to increase soft tissue volume around dental implants have long been well-described. These are represented by: pedicle soft tissue grafts (rotational flap procedures and advanced flap procedures) and free soft tissue grafts (epithelialized, also called free gingival graft (FGG), and non-epithelialized, also called, connective tissue graft (CTG) or a combination of both. To bypass the drawback connected with autologous grafts harvesting, xenogenic collagen matrices (XCM)s and collagen-based matrices derived from porcine dermis (PDXCM)s have been introduced, as an alternative, in plastic peri-implant procedures. Aim: This review is aimed to evaluate and to critically analyze the available evidence on the effectiveness of XCMs and PDXCMs in soft tissue volume augmentation around dental implants. Moreover, a clinical case with a new soft tissue grafting procedure technique (Guided Soft Tissue Regeneration, GSTR) is presented. Material and Methods: An electronic search was performed on the MEDLINE database, SCOPUS, Cochrane Library and Web of Science. The electronic search provided a total of 133 articles. One hundred and twenty-eight not meeting the inclusion criteria were excluded. Seven articles of human randomized clinical trials were selected. A total number of 108 patients were treated with CTG, and 110 patients with XCM. Results: in peri-implant soft tissue augmentation procedures, XCMs seem an effective alternative to CTGs, associated with lower patient morbidity and lower operative times.
Análise de segurança da distribuição de raízes na ICP-Brasil

Este trabalho analisa a distribuição de certificados raízes na ICPBrasil do ponto de vista de segurança. Uma prova de conceito simples é apresentada para substituir o certificado raiz distribuído no repositório oficial por um certificado falso, comprometendo a base de certificados confiados da máquina cliente, mesmo quando o procedimento sugerido de verificação é respeitado. Finalmente, algumas recomendações são apresentadas para fortalecer a distribuição de certificados, na esperança de contribuir para tornar a ICPBrasil mais robusta.
Title-Inflammatory Signaling Pathways in Allergic and Infection-Associated Lung Diseases

Lung inflammation can be caused by pathogen infection alone or by allergic disease, leading to pneumonitis. Most of the allergens (antigens) that cause allergic lung diseases, including asthma and hypersensitivity pneumonitis (HP), are derived from microorganisms, such as bacteria, viruses, and fungi, but some inorganic materials, such as mercury, can also cause pneumonitis. Certain allergens, including food and pollen, can also cause acute allergic reactions and lead to lung inflammation in individuals predisposed to such reactions. Pattern recognition-associated and damage-associated signaling by these allergens can be critical in determining the type of hypersensitization and allergic disease, as well as the potential for fibrosis and irreversible lung damage. This review discusses the signs, symptoms, and etiology of allergic asthma, and HP. Furthermore, we review the immune response and signaling pathways involved in pneumonitis due to both microbial infection and allergic processes. We also discuss current and potential therapeutic interventions for infection-associated and allergic lung inflammation.
Advertising Equal Cost Multipath routes in BGP

This document describes an extensible mechanism that will allow a BGP [BGP4] speaker to advertise ECMP routes for a destination to its peers. It uses an existing, Multi Hop Capability [M-HOP], to advertise multiple paths that it is using to its peers. The mechanism described in this document is only applicable to routers that have the ability to inject multiple routing entries in their forwarding table.
Umbilical Cord Mesenchymal Stem Cells Ameliorate Inflammation-Related Tumorigenesis via Modulating Macrophages

Mesenchymal stem cells (MSCs) have been documented to be effective for the therapy of inflammation-related diseases but raised concerns on possible tumorigenic effects. Since most of the tumors are induced or promoted by chronic inflammation, one could expect that MSCs might be beneficial for the cancer therapy because of their potent roles on inhibiting inflammation. This study is aimed at performing a safety evaluation and evaluating the role of human umbilical cord mesenchymal stem cells (HUC-MSCs) on tumorigenesis. We found that HUC-MSCs cultured within 20 generations had no significant changes in proliferation, cell cycle, cellular senescence, apoptosis, and expression of mesenchymal stem cell markers. HUC-MSCs were unable to form any tumor in immunodeficiency or normal mice with or without inflammatory stimulation. Intriguingly, we observed that HUC-MSCs inhibited tumorigenesis in B16-derived or AOM/DSS-induced colon cancer models. We reasoned that the effect of HUC-MSCs on tumorigenesis might be through regulating the inflammatory response. Indeed, HUC-MSCs dramatically ameliorated the disease symptoms and pathological changes of DSS-induced colitis mice. We deciphered the mechanism that HUC-MSCs inhibited tumorigenesis through reducing the proportion of macrophages, which were decreased in the mice suffered from AOM/DSS-induced colon cancer. Correspondingly, the expression levels of TNF-α and IL-6, which were secreted by macrophages, were significantly decreased in the plasma of colon cancer and colitis mice after injection of HUC-MSCs. This study revealed the role of inhibiting macrophages and shed light on the therapeutic application of HUC-MSCs in inflammation-induced tumorigenesis.