Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Prior Antithrombotic Use on Blood Viscosity in Cardioembolic Stroke with Non-Valvular Atrial Fibrillation

Although clinical studies have demonstrated that prior use of antiplatelets was associated with decreased blood viscosity (BV) in patients with acute ischemic stroke, the impact of previous anticoagulant use on blood viscosity in cardioembolic stroke with non-valvular AF (NVAF) has not yet been clearly studied. This single-center retrospective observational study aimed to determine the impact of prior antithrombotic (antiplatelet and anticoagulant) use on BV in patients with cardioembolic stroke (CES) due to NVAF. Patients with CES and NVAF were analyzed with the following inclusion criteria: (1) patients over 20 years of age admitted within five days of stroke onset; (2) ischemic stroke presumably due to an NVAF-derived embolus; (3) compatible cortical/subcortical lesion on brain computed tomography or magnetic resonance imaging; (4) hemoglobin level of 10–18 mg/dL; and (5) receiving antiplatelets within five days or anticoagulants within two days if previously medicated. From the screening of 195 patients (22% of the total stroke population during the study period) who had experienced ischemic stroke with AF, 160 were included for the final analysis. Eighty-nine patients (56%) were taking antithrombotics (antiplatelet, 57%; warfarin, 13%; NOACs, 30%) regularly. Compared to patients without previous antithrombotic use, those with previous antithrombotic use (antiplatelets, warfarin, and NOACs) were significantly associated with decreased systolic BV (SBV) and diastolic BV (DBV) (p < 0.036). In multiple linear regression analysis, hematocrit (Hct) level and prior antithrombotic use were significantly associated with decreased SBV and DBV. Hct was positively correlated with increased SBV and DBV. In Hct-adjusted partial correlation analysis, prior uses of any antithrombotic agents were associated with decreased SBV (r < −0.270, p < 0.015) and DBV (r < −0.183, p < 0.044). In conclusion, this study showed that prior antithrombotic use (antiplatelets, VKAs, and NOACs) was associated with decreased SBV and DBV in patients presenting with acute CES secondary to NVAF. Our results indicated that previous use of NOACs may be a useful hemorheological parameter in patients with acute CES due to NVAF. Accumulation of clinical data from a large number of patients with the risk of stroke occurrence, initial stroke severity, and functional outcome is necessary to assess the usefulness of BV.
THE HARMONIC AND NULL DESCRIPTIONS OF GRAVITATIONAL RADIATION

Abstract : The problem of an axially symmetric space-time containing gravitational waves in the usual Bondi null coordinate system is considered. This Bondi frame is then related to asymptotically harmonic coordinates by means of a characteristic initial value problem. The resultant functional relationship between the null and asymptotically harmonic frames is used to transform Bondi's radiative metric into its equivalent asymptotically harmonic form. This is then compared to the radiative solution which Fock has calculated directly using harmonic coordinates. In agreement with Fock, one finds that the harmonic form of the radiation metric contains logarithmic terms. The treatment clearly shows that these logarithmic metric components do not result from the well known logarithmic terms in the harmonic coordinate description of the light cones for Schwarzschild-like geometries. The principal result of this paper is that they arise from higher order radiative corrections.
The Role of Adiponectin during Pregnancy and Gestational Diabetes

Pregnancy involves a range of metabolic adaptations to supply adequate energy for fetal growth and development. Gestational diabetes (GDM) is defined as hyperglycemia with first onset during pregnancy. GDM is a recognized risk factor for both pregnancy complications and long-term maternal and offspring risk of cardiometabolic disease development. While pregnancy changes maternal metabolism, GDM can be viewed as a maladaptation by maternal systems to pregnancy, which may include mechanisms such as insufficient insulin secretion, dysregulated hepatic glucose output, mitochondrial dysfunction and lipotoxicity. Adiponectin is an adipose-tissue-derived adipokine that circulates in the body and regulates a diverse range of physiologic mechanisms including energy metabolism and insulin sensitivity. In pregnant women, circulating adiponectin levels decrease correspondingly with insulin sensitivity, and adiponectin levels are low in GDM. In this review, we summarize the current state of knowledge about metabolic adaptations to pregnancy and the role of adiponectin in these processes, with a focus on GDM. Recent studies from rodent model systems have clarified that adiponectin deficiency during pregnancy contributes to GDM development. The upregulation of adiponectin alleviates hyperglycemia in pregnant mice, although much remains to be understood for adiponectin to be utilized clinically for GDM.
Enzyme‐Cleaved Bone Marrow Transplantation Improves the Engraftment of Bone Marrow Mesenchymal Stem Cells

Mesenchymal stem cell (MSC) therapy is a promising approach to curing bone diseases and disorders. In treating genetic bone disorders, MSC therapy is local or systemic transplantation of isolated and in vitro proliferated MSC rather than bone marrow transplantation. Recent evidence showed that bone marrow MSC engraftment to bone regeneration has been controversial in animal and human studies. Here, our modified bone marrow transplantation (BMT) method solved this problem. Like routine BMT, our modified method involves three steps: (i) isolation of bone marrow cells from the donor, (ii) whole‐body lethal irradiation to the recipient, and (iii) injection of isolated bone marrow cells into irradiated recipient mice via the tail vein. The significant modification is imported at the bone marrow isolation step. While the bone marrow cells are flushed out from the bone marrow with the medium in routine BMT, we applied the enzymes’ (collagenase type 4 and dispase) integrated medium to wash out the bone marrow cells. Then, cells were incubated in enzyme integrated solution at 37°C for 10 minutes. This modification designated BMT as collagenase‐integrated BMT (c‐BMT). Notably, successful engraftment of bone marrow MSC to the new bone formation, such as osteoblasts and chondrocytes, occurs in c‐BMT mice, whereas routine BMT mice do not recruit bone marrow MSC. Indeed, flow cytometry data showed that c‐BMT includes a higher proportion of LepR+, CD51+, or RUNX2+ non‐hematopoietic cells than BMT. These findings suggested that c‐BMT is a time‐efficient and more reliable technique that ensures the disaggregation and collection of bone marrow stem cells and engraftment of bone marrow MSC to the recipient. Hence, we proposed that c‐BMT might be a promising approach to curing genetic bone disorders. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Dielectric breakdown of MgO magnetic tunnel junctions

We have investigated high-quality MgO tunnel junctions with a range of barrier thickness in order to identify the underlying physical mechanism responsible for dielectric breakdown. Two types of dielectric breakdown (“soft” and “hard”) were observed. Soft breakdown was observed in a few percent of the devices. This breakdown mode is not intrinsic and is attributed to tunnel junction imperfections. The hard breakdown occurs because a critical electric field is reached across the tunnel barrier. Other possible breakdown mechanisms, such as thermally driven mass diffusion or charge trapping, were not consistent with the hard dielectric breakdown data and were ruled out.
Hauteur de Faltings de quotients de J0(N), discriminants d'algèbres de Hecke et congruences entre formes modulaires

In this paper we compute the Faltings height of the Jacobian of the modular curve J 0 ( N ). We explain how it is related to the discriminant of the Hecke algebra. This discriminant measures congruences between modular forms. As a corollary we obtain a lower bound for this discriminant. The Faltings height of a quotient A of J 0 ( N ) is also computed.
Electro-Nano Diagnostic Platform Based on Antibody–Antigen Interaction: An Electrochemical Immunosensor for Influenza A Virus Detection

H1N1 is a kind of influenza A virus that causes serious health issues throughout the world. Its symptoms are more serious than seasonal flu and can sometimes be lethal. For this reason, rapid, accurate, and effective diagnostic tests are needed. In this study, an electrochemical immunosensor for the sensitive, selective, and practical detection of the H1N1 virus was developed. The sensor platform included multi-walled carbon nanotube gold-platinum (MWCNT-Au-Pt) hybrid nanomaterial and anti-hemagglutinin (anti-H1) monoclonal antibody. For the construction of this biosensor, a gold screen-printed electrode (AuSPE) was used as a transducer. Firstly, AuSPE was modified with MWCNT-Au-Pt hybrid nanomaterial via drop casting. Anti-H1 antibody was immobilized onto the electrode surface after the modification process with cysteamine was applied. Then, the effect of the interaction time with cysteamine for surface modification was investigated. Following that, the experimental parameters, such as the amount of hybrid nanomaterial and the concentration of anti-H1 were optimized. Under the optimized conditions, the analytical characteristics of the developed electrochemical immunosensor were investigated for the H1N1 virus by using electrochemical impedance spectroscopy. As a result, a linear range was obtained between 2.5–25.0 µg/mL with a limit of the detection value of 3.54 µg/mL. The relative standard deviation value for 20 µg/mL of the H1N1 virus was also calculated and found as 0.45% (n = 3). In order to determine the selectivity of the developed anti-H1-based electrochemical influenza A immunosensor, the response of this system towards the H3N2 virus was investigated. The matrix effect was also investigated by using synthetic saliva supplemented with H1N1 virus.
Integrated Voltage Harmonics Factors Estimation of Single-Phase Multilevel Voltage Source Inverter under Simple Quarter-Wave-Symmetric Space Vector PWM Control

The harmonics-related voltage characteristics of the simple quarter-wave-symmetric space vector pulse width modulation (QWS-SVPWM) technique for single-phase multilevel voltage source inverter (MLVSI) are presented. The just offered approach applies the integer part of the reference voltage sample as the coordinate of the first modulating space vector and the fractional part as the duty cycle of the second (adjacent) modulating vector. This significantly reduces the computational costs. The considered harmonics factors are the output voltage THD and n-order weighted THDs. It is the latter that are appropriate for the load circuit elements current and voltage THD assessment when the load simplified equivalent circuits are the respective-order ones. Here the range of the voltage amplitude modulation index is considerably extended for the characteristics dependences thanks to using LabVIEW signal simulation model instead of PSIM model of the whole inverter system. The simulation results confirm the low-frequency QWS-SVPWM readiness to provide a high quality supplying loads by the single-phase MLVSI with enough high number of the levels.
A note on the occurrence of cloud in meteorologically sensitive areas and the implications for advanced infrared sounders

The geographical distribution and persistence of meteorologically sensitive areas (derived using adjoint forecast‐error tracking techniques) are investigated with respect to the occurrence of cloud. Using sensitivity patterns and cloud structures simulated from the ECMWF forecast model a high degree of correlation is found which, if realistic, could limit the ability of space‐based advanced infrared sounders to measure important meteorological features. The result underlines the need to develop techniques to use infrared sounder observations in the presence of cloud. Copyright © 2002 Royal Meteorological Society
Convertir des grammaires d’arbres adjoints à composantes multiples avec tuples d’arbres (TT-MCTAG) en grammaires à concaténation d’intervalles (RCG)

Cet article étudie la relation entre les grammaires d’arbres adjoints à composantes multiples avec tuples d’arbres (TT-MCTAG), un formalisme utilisé en linguistique informatique, et les grammaires à concaténation d’intervalles (RCG). Les RCGs sont connues pour décrire exactement la classe PTIME, il a en outre été démontré que les RCGs « simples » sont même équivalentes aux systèmes de réécriture hors-contextes linéaires (LCFRS), en d’autres termes, elles sont légèrement sensibles au contexte. TT-MCTAG a été proposé pour modéliser les langages à ordre des mots libre. En général ces langages sont NP-complets. Dans cet article, nous définissons une contrainte additionnelle sur les dérivations autorisées par le formalisme TT-MCTAG. Nous montrons ensuite comment cette forme restreinte de TT-MCTAG peut être convertie en une RCG simple équivalente. Le résultat est intéressant pour des raisons théoriques (puisqu’il montre que la forme restreinte de TT-MCTAG est légèrement sensible au contexte), mais également pour des raisons pratiques (la transformation proposée ici a été utilisée pour implanter un analyseur pour TT-MCTAG).
Determination the characteristic parameter of nano-film based on spectroscopic ellipsometry by improved adaptive genetic algorithm

In order to obtain accurate nano-film characteristic parameters in the ellipsometry measurement process, an optimization algorithm for solving the thickness and complex refractive index of nano films by spectroscopic ellipsometry is proposed. An improved adaptive genetic algorithm (IAGA) has been proposed to process nano-film data, this method combines the evolutionary algebraic attenuation factor with the adaptive genetic algorithm. It can solve the problem that the genetic algorithm is premature and easy to fall into the local optimization. The algorithm is used to calculate the film parameters of silicon dioxide nano film thickness standard template with standard value of 49.7±0.4 nm in this paper. The results show that the relative error of the calculation results of the film thickness is less than 3%, and the error of refractive index is less than 0.1. At the same time, it is verified by experiments that the IAGA algorithm model can effectively optimize the number of iterations, and has the advantages of fast convergence speed and high measurement efficiency.
A Review on Advanced Nanomaterials for Antibacterial Applications

The management of infectious diseases is one of the major public health challenges of the 21st century. Mutation of the microbes, biofilm formation, and other structural-morphological behaviors have resulted in pathogens acquiring multi-drug resistance. The development of advanced materials that can provide long-lasting and effective protection against harmful microbes is becoming a need of the hour. Biocompatibility, efficient microbial inactivation, thermal and chemical stability of nanomaterials help to reduce the excessive use of antibiotics and, thus, to overcome antimicrobial resistance. Metal and metal oxide nanostructures, graphene, carbon dots, and other two-dimensional materials exhibit excellent antimicrobial properties. This review provides a comprehensive overview of antibacterial mechanisms and factors that help to inactivate the bacteria by nanomaterials. It also points out the enhanced antibacterial behaviors of the modified nanomaterials for future research concerns.
Analysis of Heart Sound Signals using Sparse Modeling with Gabor Dictionary

We propose applying sparse modeling using matching pursuit with a Gabor dictionary of scaled time-frequency atoms to analyze and approximate the heart sound signals of the PhysioNet2016 challenge. The time and frequency resolution of the dictionary is governed by a scaling factor, and the atoms temporally overlap by 50% of their temporal duration. We aim to optimize the time and frequency resolution of the dictionary to achieve the highest approximation quality at the desired sparsity. We also investigate the approximation quality of matching pursuit with a reduced size dictionary constructed from either overlapping or nonoverlapping atoms with downsampled frequency resolution. Experimental analysis shows that a dictionary of balanced time and frequency resolution performs well for highly sparse approximations of the signals. Moreover, the highest approximation quality is obtained when the approximation become less sparse, with a dictionary containing atoms of high time and low frequency resolution. On the other hand, a half-size dictionary of overlapping atoms with downsampled frequency resolution performs well in comparison to the original full-size dictionary. Furthermore, the approximation quality is highly degraded when the dictionary contains nonoverlapping atoms rather than atoms with downsampled frequency resolution.
A field study of nocturnal stratocumulus II Turbulence structure and entrainment

Tethered balloon‐borne instrumentation has been used to study the small‐scale air motion and temperature variations occurring within a layer of nocturnal stratocumulus. The observations indicate a very sharp and intermittently turbulent entrainment interfacial layer with some evidence for a characteristic entrainment scale of about 10m. Within the cloud layer convective motions are apparent and these take the form of cold, downward moving plumes which increase in scale away from cloud top. They are generated by the large radiative loss from the upper part of the cloud. Some statistical features of the turbulence field in cloud are discussed and compared with other observations from stratocumulus and the daytime convective boundary layer.
Fabrication of Flexible All-Solid-State Asymmetric Supercapacitor Device via Full Recycling of Heated Tobacco Waste Assisted by PLA Gelation Template Method

In this study, a flexible all-solid-state asymmetric supercapacitor (FASC) device has been successfully fabricated via full recycling of heated tobacco waste (HTW). Tobacco leaves and cellulose acetate tubes have been successfully carbonized (HTW-C) and mixed with metal oxides (MnO2 and Fe3O4) to obtain highly active materials for supercapacitors. Moreover, poly(lactic acid) (PLA) filters have been successfully dissolved in an organic solvent and mixed with the as-prepared active materials using a simple paste mixing method. In addition, flexible MnO2- and Fe3O4-mixed HTW-C/PLA electrodes (C-MnO2/PLA and C-Fe3O4/PLA) have been successfully fabricated using the drop-casting method. The as-synthesized flexible C-MnO2/PLA and C-Fe3O4/PLA electrodes have exhibited excellent electrical conductivity of 378 and 660 μS cm−1, and high specific capacitance of 34.8 and 47.9 mF cm−2 at 1 mA cm−2, respectively. A practical FASC device (C-MnO2/PLA//C-Fe3O4/PLA) has been assembled by employing the C-MnO2/PLA as the positive electrode and C-Fe3O4/PLA as the negative electrode. The as-prepared FASC device showed a remarkable capacitance of 5.80 mF cm−2 at 1 mA cm−2. Additionally, the FASC device manifests stable electrochemical performance under harsh bending conditions, verifying the superb flexibility and sustainability of the device. To the best of our knowledge, this is the first study to report complete recycling of heated tobacco waste to prepare the practical FASC devices. With excellent electrochemical performance, the experiments described in this study successfully demonstrate the possibility of recycling new types of biomass in the future.
Functional Analysis of Bna-miR399c-PHO2 Regulatory Module Involved in Phosphorus Stress in Brassica napus

Phosphorus stress is one of the important factors restricting plant growth and development, and the microRNA (miRNA) family is involved in the regulation of the response to plant nutrient stress by repressing the expression of target genes at the post-transcriptional or translational level. miR399 is involved in the transportation of phosphate in multiple plants by improving tolerance to low Pi conditions. However, the effect of miR399 on the response of low Pi stress in rapeseed (Brassica napus L.) is unclear. The present study showed a significant increase in taproot length and lateral root number of plants overexpressing Bna-miR399c, while the biomass and Pi accumulation in shoots and roots increased, and the anthocyanin content decreased and chlorophyll content improved under low Pi stress. The results illustrate that Bna-miR399c could enhance the uptake and transportation of Pi in soil, thus making B. napus more tolerant to low Pi stress. Furthermore, we confirmed that BnPHO2 is one of the targets of Bna-miR399c, and the rejection of Pi in rapeseed seedlings increased due to the overexpression of BnPHO2. Hence, we suggest that miR399c-PHO2 module can effectively regulate the homeostasis of Pi in B. napus. Our study can also provide the theoretical basis for germplasm innovation and the design of intelligent crops with low nutrient input and high yield to achieve the dual objectives of income and yield increase and environmental protection in B. napus.
Age of Information for Short-Packet Relay Communications in Cognitive-Radio-Based Internet of Things With Outdated Channel State Information

It is crucial to consider time-critical communications in cognitive-radio-based Internet of Things (CR-IoT), which increasingly rely on the exchange of short-packet information to efficiently monitor and control. Therefore, the age of information (AoI) is exploited as a timeliness metric in this paper to investigate the freshness of received information at the remote server with dual-hop short-packet communications in underlay CR-IoT. Since short-packet communications are sensitive to time delay, the influence of outdated factors in the channel state information (CSI) cannot be ignored, so we develop the system under the condition of outdated CSI with Nakagami- ${m}$ fading channels. Considering the impact of outdated CSI and packets error, we investigate the performance of dual-hop short-packet communications under the classical automatic repeat-request (ARQ) protocol and truncated ARQ (TARQ) protocol, and obtain the approximated expressions of the average AoI and the average peak AoI (PAoI), respectively. Accordingly, the blocklength and the number of retransmissions can be optimized by Fibonacci and iterative algorithms to minimize the average PAoI under two protocols, respectively. Simulation results substantiate the influence of each parameter on the system performance differently under two different protocols. Moreover, the AoI of the dual-hop is also better than that of the single-hop due to the interference threshold of the primary user.