Miracle-dz/UniFAR-FTUs huggingface dataset:
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In this paper, we describe a novel approach to measure the susceptibility of smartphone unlock authentication to shoulder surﬁng attacks. In our methodology, participants play the role of attackers, viewing video-recorded footage of PIN and graphical password pattern authentication input with various camera angles, hand positions, phone sizes, and authentication length and strength. Based on the data collected and recording methodology developed, we aim to provide insight into the factors of mobile unlock authentication which best and least resist shoulder surﬁng attacks and examine scenarios where weaknesses may occur. The goal is to identify more effective guidance for mobile device users to avoid observational attacks. We also aim to advance the methodologies used to measure the shoulder surﬁng attack surfaces where baselines of comparisons to preexisting systems (e.g., PINs and patterns) are not standardized. Utilizing the methodology and recordings, other researchers may build upon this approach to analyze future systems and replicate our results.
IscR‐dependent gene expression links iron‐sulphur cluster assembly to the control of O2‐regulated genes in Escherichia coli

IscR is an iron‐sulphur (Fe‐S) cluster‐containing transcription factor that represses transcription of the operon containing its own gene and the iscSUA‐hscBA‐fdx genes, whose products are involved in Fe‐S cluster biogenesis. In this study, global transcriptional profiling of Escherichia coli IscR+ and IscR– strains grown under aerobic and anaerobic conditions indicated that 40 genes in 20 predicted operons were regulated by IscR. DNase I footprinting and/or in vitro transcription reactions identified seven new promoters under direct IscR control. Among these were genes encoding known or proposed functions in Fe‐S cluster biogenesis (sufABCDSE, yadR and yhgI) and Fe‐S cluster‐containing anaerobic respiratory enzymes (hyaABCDEF, hybOABCDEFG and napFDAGHBC). The finding that IscR repressed expression of the hyaA, hybO and napF promoters specifically under aerobic growth conditions suggests a new mechanism to explain their upregulation under anaerobic growth conditions. Phylogenetic footprinting of the DNase I protected regions of seven promoters implies that there are at least two different classes of IscR binding sites conserved among many bacteria. The findings presented here indicate a more general role of IscR in the regulation of Fe‐S cluster biogenesis and that IscR contributes to the O2 regulation of several promoters controlling the expression of anaerobic Fe‐S proteins.
Economía colaborativa: análisis de la producción científica en revistas académicas

Resumo Propiciada pelas novas tecnologias e internet e acrescida pela crise surge a Economia Colaborativa, um movimento que permite a individuos utilizar e trocar servicos ou bens objetivando uma compensacao acordada entre as partes. O objetivo deste estudo e mostrar o estado atual da investigacao cientifica sobre Economia Colaborativa. A metodologia utilizada e uma analise bibliometrica de caracter descritivo e exploratorio dos artigos publicados em revistas indexadas a base de dados Scopus (Elsevier). Mediante uma procura avancada de termos foram identificados e analizados 165 documentos. Os resultados obtidos demonstram o crescente interesse da comunidade cientifica, principalmente nos paises anglo-saxoes (Estados Unidos e Reino Unido) pelo tema nos ultimos cinco anos, motivado por seu rapido crescimento e seus efeitos sobre diversos aspectos do modelo de vida atual. Encontrou-se um maior numero de publicacoes nas areas de ciencias sociais, informatica e empresa, administracao e contabilidade.
Online Submission ID : 207 Creating Meaningful Environment Models for Augmented Reality

This article introduces a framework to generate three-dimensional models for Augmented Reality (AR), which include semantics. Augmented reality applications often associate 3D models with some aspect of reality. While the addition of semantics to 3D models has been studied previously in the field of intelligent virtual environments, AR is different because the semantics are attached to objects existing in the real world. Moreover, little attention has been paid to the process of creating real-world models containing such information. This work describes a method for the creation of “meaningful” models of the environment in an AR application named InventAry. Assisted by an ontology, InventAry enforces the creation of combined geometric and semantic environment model.
Improved Approximation Algorithms for Multidepot Capacitated Vehicle Routing

The Multidepot Capacitated Vehicle Routing Problem (MCVRP) is a well-known variant of the classic Capacitated Vehicle Routing Problem (CVRP), where we need to route capacitated vehicles located in multiple depots to serve customers' demand such that each vehicle must return to the depot it starts, and the total traveling distance is minimized. There are three variants of MCVRP according to the property of the demand: unit-demand, splittable and unsplittable. We study approximation algorithms for $k$-MCVRP in metric graphs where $k$ is the capacity of each vehicle, and all three versions are APX-hard for any constant $k\geq 3$. Previously, Li and Simchi-Levi proposed a $(2\alpha+1-\alpha/k)$-approximation algorithm for splittable and unit-demand $k$-MCVRP and a $(2\alpha+2-2\alpha/k)$-approximation algorithm for unsplittable $k$-MCVRP, where $\alpha=3/2-10^{-36}$ is the current best approximation ratio for metric TSP. Harks et al. further improved the ratio to 4 for the unsplittable case. We give a $(4-1/1500)$-approximation algorithm for unit-demand and splittable $k$-MCVRP, and a $(4-1/50000)$-approximation algorithm for unsplittable $k$-MCVRP. Furthermore, we give a $(3+\ln2-\max\{\Theta(1/\sqrt{k}),1/9000\})$-approximation algorithm for splittable and unit-demand $k$-MCVRP, and a $(3+\ln2-\Theta(1/\sqrt{k}))$-approximation algorithm for unsplittable $k$-MCVRP under the assumption that the capacity $k$ is a fixed constant. Our results are based on recent progress in approximating CVRP.
A comparative study on the Refractive Index of Silk Protein Thin Films and Silk Protein Resist Thin Films.

In the last two decades Silk Fibroin due to the combination of unique properties has been exploited as optical materials in biological application. Recently a protocol has been developed to produce a Silk Fibroin resist crosslinkable via UV photolithography. The same protocol has been applied to Sericine to develop a Silk Sericine resist. Despite the use of these materials to develop micro patterns on silicon and glass surfaces, and self-standing micro optical components, their refractive index has never been characterized. In this work, optimizing a method to obtain extremely smooth and thin films we were able to characterize by ellipsometry the refractive index of both Sericine and Fibroin Resist. In addition, we report as reference the refractive index of: silk sericine obtained from formic acid solution and silk fibroin obtained both from formic acid and water solutions. The parameters of the Sellmaier and Cauchy dispersion laws have been determined. The differences of refractive index of Silk Fibroin films produced by different solvents has been explained examining the change in the protein secondary structure, moreover a complete morphological study of the films has been conducted. Graphical abstract
Lacunes

Neurology 1965;15:774-784 Lacunes may be defined as ischemic infarcts of restricted size in the deeper parts of the brain. Absent from the cerebral and cerebellar cortex, they are best known in the chronic healed stage when they form irregular cavities, 0.5 to 15 mm. in diameter, principally in the basal ganglia and basis pontis (Figs. 1, 2, 3, 4, and 5). Although outnumbering all the other varieties of cerebrovascular lesion combined,1 lacunes are not as well known to the neurologist as they deserve to be. The present paper is a survey of the pathological findings in a series of patients with lacunes autopsied at a general hospital. While it was possible to correlate lacunes with the occurrence of cerebral atherosclerosis and arterial hypertension, the clinical details in the cases were so deficient that a good clinicopathologic correlation could not be made. Fig. 1. Section showing lacunes in putamen and head of caudate nucleus Fig. 2. Lacunes in thalamus and opposite putamen Fig. 3. Lacune in basis pontis Fig. 4. Lacune in frontal white matter Fig. 5. Lacunes in deep parietal white matter The term lacune can be traced back to Durand-Fardel2 who in his treatise on softening of the brain described the pathological findings in his case No. 78 as follows: "The striatum on each side showed a certain number of small lacunes with no associated alteration of color or consistency from whose surface there extended a fine meshwork containing very small vessels. " Elsewhere in the same monograph the author described for the first time etat crible (riddled with shot or sievelike) consisting of numerous canals or small round holes in the cerebral tissue from each of which a small vessel projected and which were located in the striatum, thalamus, and cerebral white matter. That he was not …
An Unusual Case of Isolated Native Pulmonic Valve Enterococcus faecalis Endocarditis

A patient with long standing history of End Stage Renal Disease (ESRD) on hemodialysis (HD) and breast cancer is admitted for weakness and fever. Blood culture showed Enterococcus faecalis. Transthoracic echocardiogram revealed a 0.8 cm circular echodensity on ventricular surface of pulmonary valve protruding into RV during diastole. She was successfully treated with IV antibiotics.
Population Health Management exploiting Machine Learning to identify High Risk Patients

— Population aging and the increase of chronic conditions incidence and prevalence produce a higher risk of hospitalization or death. This is particularly high for patients with multimorbidity leading to a great consumption of resources. Identifying as soon as possible high-risk patients becomes an important challenge to improve health care service provision and to reduce costs. Nowadays, population health management, based on intelligent models, can be used to assess the risk and identify these “complex” patients. The aim of this study is to validate machine learning algorithms (Naïve Bayes, Cart, C5.0, Conditional Inference Tree, Random Forest, Artificial Neural Network and LASSO) to predict the risk of hospitalization or death starting from administrative and socio-economics data. The study involved the residents in the Local Health Unit of Central Tuscany.
Immunohistochemical Study of Histone Protein 3 Modification in Pediatric Osteosarcoma Identifies Reduced H3K27me3 as a Marker of Poor Treatment Response

The most common pediatric primary malignant bone tumor, osteosarcoma, is often described as genetically non-recurrent and heterogeneous. Neoadjuvant chemotherapy is typically followed by resection and assessment of treatment response, which helps inform prognosis. Identifying biomarkers that may impact chemotherapy response and survival could aid in upfront risk stratification and identify patients in highest need of innovative therapies for future clinical trials. Relative to conventional genetics, little is known about osteosarcoma epigenetics. We aimed to characterize the methylation and phosphorylation status in osteosarcoma using histone markers found in primary diagnostic biopsies and their paired metastases. We constructed two tissue microarray sets from 58 primary diagnostic samples and 54 temporally-separated but related metastatic or recurrent samples, with tissue blocks available from 2002-2022. Clinical charts were reviewed for post-therapy necrosis response, presence of metastatic disease or recurrence, and overall survival. We evaluated 6 histone H3 residues using immunohistochemistry, including H3K4me3, H3K9me3, H3K27me2, H3K27me3, H3S10T11phos, and H3S28phos. Tumors were scored with low (<25%) or high ([≥]25%) nuclear staining of tumor cells. Diagnostic biopsies with low H3K27me3 nuclear staining were associated with poor treatment response ([≤]90% necrosis) at the time of definitive excision (P<0.05). We observed loss of H3S10T11phos expression in metastatic and recurrent resections specimens compared to the primary tumor (P<0.05). Expression patterns for the remaining histone markers did not show significant associations with disease parameters or survival. Although larger cohort studies are needed, these results support the expanded evaluation of histone markers, particularly H3K27me3 and H3S10T11phos, in osteosarcoma biology and risk stratification.
American Journal of Surgery and Clinical Case Reports

: Multiple primary carcinomas (MPCs), first re-ported by Billroth in 1879, are defined as two or more synchronous or metachronous cancers unrelated to each other in the same individual. MPCs are rare, especially synchronous signet ring cell carcinomas (SRCCs) of the digestive tract. In this report, we pres-ent a rare case of a male patient with synchronous SRCCs in the esophagus, stomach, duodenum, ileocecum and colorectum. 1.2. Case Presentation: A 64-year-old man with a medical history of diabetes mellitus presented with symptoms of abdominal dis - tension, diarrhea and back pain accompanied by significant weight loss. Physical examination of the patient revealed no abnormal findings and there was no specific family history. Gastrointestinal endoscopy revealed multiple protruding lesions with central depression and erosion in the esophagus, stomach, duodenum, ileocecum, and colorectum, and biopsy of the lesions indicated SRCC. Immunohistochemical staining showed a negative result for cytokeratin 7 (CK7) and a positive result for cytokeratin 20 (CK20) and mucin 2 (MUC2). Due to the wide range of lesions, systemic chemotherapy was given in this case. The patient eventu - ally died five months after the discharge.
Noninternalizing monoclonal antibodies are suitable candidates for I 125 radioimmunotherapy of small-volume peritoneal carcinomatosis

We have previously shown that, monoclonal antibodies (mAbs) labeled with the Auger electron emitter I are more in vitro, 125 cytotoxic if they remain at the cell surface and do not internalize in the cytoplasm. Here, we assessed the biological efficiency in vivo of internalizing and non internalizing I-labeled mAbs for the treatment of small solid tumors. 125
Economic impacts of hosting a major sporting event : Did the 1998 FIFA World Cup have positive impacts on employment?

This paper examines the effects on employment due to a mega-sport event and more precisely this study demonstrates that the 1998 Football World cup in France had a significant positive effect on employment in the host regions. Moreover, it shows the impact differences between the host regions where some have been more affected than other. This work is the first to analyze the effect on employment in the host regions using a Difference in Difference approach. The basic DID model is then improved to add new parameters in the regression. It is one of the rare studies to find a significant positive impact on the economy owing of the World cup or the Olympic Games.
EXPLORING THE ATTRIBUTES OF OPEN PUBLIC SPACES IN THE DEVELOPING CITIES

Open Public Spaces, according to Commission for Architecture and the Built Environment (CABE), are vital elements of urban fabrics that animate communities in cities. These significant spaces not only provide the residents with different facilities, but also promote social, economic, environmental and health opportunities. Successful open public spaces meet the needs of people of various social classes, ethnicities, and different backgrounds in general. Despite its importance within the city, the lack of appropriate design and planning strategies in developing cities have resulted in a degradation of the urban environment and subsequently the quality of urban life. The problem needs to be addressed with sensitivity to space as well as the people- its main users. The research, therefore, aims to explore the attributes of successful open public spaces that contributes to enhance the quality of public life from users’ perspective. The research focuses on one case study: Horsh Al-Sanawbar, Beirut, Lebanon, which is perceived as the largest green public space in the heart of Beirut, where it plays a significant role in enhancing the public quality within the city. The paper argues that open public space dimensions consist of several attributes that makes an open public space successful, where these spaces can act as catalysts for enhancing the quality of life within the developing city. To prove this hypothesis, the paper adopts a qualitative approach, first, through desk research for defining the main keyword, and examining data from previous works and articles on the same topic wrote by various architects, urban planners, and theorists. Second a field methodology will be supported by questionnaire survey, walking interviews, and onsite observations regarding the four key attributes of successful open public spaces that are: physical, social, functional, and perceptual attributes. The author finally suggests a series of dimensions found in the design and development of open public spaces, that will contribute to create a design guideline for using the attributes in achieving better open public spaces.
in neurological practice

© Feeling unhappy about being ill seems so understandable – but it is easy to forget that the majority of people do not suffer from sustained low mood when they have a physical disease, even a chronic and disabling one (see Robertson and Katona 1997, for review). For those who do have a depressive disorder co-existent with physical illness, the result seems to be a lower quality of life, and worse outcomes from treatment (Creed et al. 2002). The recognition and treatment of co-existent depression ought therefore to be a part of the management of all chronic disease, and neurology is no exception. Review articles, like chess games, have a limited number of conventional openings. The next move in developing the current argument would normally be to lament the hopelessness of most doctors when it comes to recognizing depression in their clinical practice, before going on to offer the Psychiatrists’ Gambit – routine use of a screening instrument followed by treatment, or referral for high scorers. Variations revolve around the specifi cs of the recommended screening instrument and antidepressant medication. This line is familiar and looks plausible, but it has a fl aw and that is – we don’t know exactly what we mean by depression. If we don’t know what we’re looking for then it’s not surprising that depression is under-recognized or that advice about best treatment is so hard to come by.
MEDICAL SCIENCES AND PUBLIC

Results and Discussion : Clinical data from 50 children diagnosed with traumatic brain injury (TBI) who were admitted to our hospital were used to assess the study results. The age of the children ranged from 2 to 16 years, with a mean age of 9.6 years. Among them, 38 children (76%) had blunt trauma, while 12 (24%) had penetrating trauma.
Multilevel Governance of Global Environmental Change: Self-regulation of industry and the law

List of contributors Introduction Gerd Winter Part I. Earth System Analysis: 1. Dimensions and mechanisms of global climate change Peter Lemke 2. Global climate change - what can we learn from the past? Stefan Rahmstorf Part II. Society and Institutions of Global Environmental Change: 3. The social embeddedness of global environmental governance Karl-Werner Brand and Fritz Reusswig 4. Globalising a green civil society Asher Alkoby Part III. Self-Regulation of Industry and the Law: 5. Private authority, global governance and the law Martin Herberg 6. Responsibility of transnational corporations in international environmental law: three perspectives Andre Nollkaemper 7. Transboundary corporate responsibility in environmental matters: fragments and foundations for a future framework Jonas Ebbesson 8. The diffusion of environmental policy innovations Kerstin Tews 9. Process related measures and global environmental governance Christian Tietje 10. The impact of the U.S.A. on regime formation and implementation Thomas Giegerich 11. Transnational bureaucracy networks, a resource of global environmental governance? Michael Warning 12. The EU - a regional model? Ludwig Kraemer 13. Transition and governance: the case of post-Communist states Stephen Stec, Alexios Antypas and Tamara Steger 14. Multilateral environmental agreements and the compliance continuum Jutta Brunnee 15. On clustering international environmental agreements Konrad von Moltke 16. Institutions, knowledge and change: findings from the quantitative study of environmental regimes Helmut Breitmeier 17. Regulatory competition and developing countries and the challenge for compliance - push and pull measures Joyeeta Gupta 18. Policy instrument innovation in the European Union: a realistic model for international environmental governance? Andrew Jordan, Rudiger K. W. Wurzel and Anthony R. Zito 19. Financial instruments and cooperation in implementing international agreements for the global environment Charlotte Streck 20. Global environmental change and the nation state: sovereignty bounded? Peter H. Sand 21. Whose environment? - concepts of commonality in international environmental law Michael Bothe 22. Globalising environmental liability: the interplay of national and international law A. E. Boyle 23. The legal nature of environmental principles in international, EU and exemplary national law Gerd Winter.
Studio del metodo dell'assorbimento diretto della CO2 per l'analisi del radiocarbonio

L’attuale rilevanza rappresentata dalla stretta relazione tra cambiamenti climatici e influenza antropogenica ha da tempo posto l’attenzione sull’effetto serra e sul surriscaldamento planetario cosi come sull’aumento delle concentrazioni atmosferiche dei gas climaticamente attivi, in primo luogo la CO2. Il radiocarbonio e attualmente il tracciante ambientale per eccellenza in grado di fornire mediante un approccio “top-down” un valido strumento di controllo per discriminare e quantificare il diossido di carbonio presente in atmosfera di provenienza fossile o biogenica. Ecco allora che ai settori applicativi tradizionali del 14C, quali le datazioni archeometriche, si affiancano nuovi ambiti legati da un lato al settore energetico per quanto riguarda le problematiche associate alle emissioni di impianti, ai combustibili, allo stoccaggio geologico della CO2, dall’altro al mercato in forte crescita dei cosiddetti prodotti biobased costituiti da materie prime rinnovabili. Nell’ambito del presente lavoro di tesi e stato quindi esplorato il mondo del radiocarbonio sia dal punto di vista strettamente tecnico e metodologico che dal punto di vista applicativo relativamente ai molteplici e diversificati campi d’indagine. E’ stato realizzato e validato un impianto di analisi basato sul metodo radiometrico mediante assorbimento diretto della CO2 ed analisi in scintillazione liquida apportando miglioramenti tecnologici ed accorgimenti procedurali volti a migliorare le performance del metodo in termini di semplicita, sensibilita e riproducibilita. Il metodo, pur rappresentando generalmente un buon compromesso rispetto alle metodologie tradizionalmente usate per l’analisi del 14C, risulta allo stato attuale ancora inadeguato a quei settori applicativi laddove e richiesta una precisione molto puntuale, ma competitivo per l’analisi di campioni moderni ad elevata concentrazione di 14C. La sperimentazione condotta su alcuni liquidi ionici, seppur preliminare e non conclusiva, apre infine nuove linee di ricerca sulla possibilita di utilizzare questa nuova classe di composti come mezzi per la cattura della CO2 e l’analisi del 14C in LSC.