Miracle-dz/UniFAR-FTUs huggingface dataset:
Implications of physics, chemistry and biology for dosimetry calculations using theranostic pairs

Theranostics is an emerging paradigm that combines imaging and therapy in order to personalize patient treatment. In nuclear medicine, this is achieved by using radiopharmaceuticals that target identical molecular targets for both imaging (using emitted gamma rays) and radiopharmaceutical therapy (using emitted beta, alpha or Auger-electron particles) for the treatment of various diseases, such as cancer. If the therapeutic radiopharmaceutical cannot be imaged quantitatively, a “theranostic pair” imaging surrogate can be used to predict the absorbed radiation doses from the therapeutic radiopharmaceutical. However, theranostic dosimetry assumes that the pharmacokinetics and biodistributions of both radiopharmaceuticals in the pair are identical or very similar, an assumption that still requires further validation for many theranostic pairs. In this review, we consider both same-element and different-element theranostic pairs and attempt to determine if factors exist which may cause inaccurate dose extrapolations in theranostic dosimetry, either intrinsic (e.g. chemical differences) or extrinsic (e.g. injecting different amounts of each radiopharmaceutical) to the radiopharmaceuticals. We discuss the basis behind theranostic dosimetry and present common theranostic pairs and their therapeutic applications in oncology. We investigate general factors that could create alterations in the behavior of the radiopharmaceuticals or the quantitative accuracy of imaging them. Finally, we attempt to determine if there is evidence showing some specific pairs as suitable for theranostic dosimetry. We show that there are a variety of intrinsic and extrinsic factors which can significantly alter the behavior among pairs of radiopharmaceuticals, even if they belong to the same chemical element. More research is needed to determine the impact of these factors on theranostic dosimetry estimates and on patient outcomes, and how to correctly account for them.
Integrated current-programming controller for DC-DC converters using current-mode analogue processing techniques

This paper reports on the design and simulation of a current-programming controller for DC-DC switched power converters. The proposed analogue circuit allows custom integrated circuit (IC) implementation, which apart from a reduction in cost, mass and weight increases reliability. Current-mode VLSI analogue signal processing techniques are considered, resulting in a compact design suitable for high-frequency cycle-by-cycle control. The control circuitry has been laid-out in a standard 0. 8μm CMOS technology. Post-layout simulation results for this monolithic controller show proper operation at 1Mhz switching frequency.
Properties of Spark Plasma Sintered Compacts and Magnetron Sputtered Coatings Made from Cr, Mo, Re and Zr Alloyed Tungsten Diboride

To enhance the properties of tungsten diboride, we have synthesized and characterized solid solutions of this material with chromium, molybdenum, rhenium and zirconium. The obtained materials were subsequently deposited as coatings. Various concentrations of these transition metal elements, ranging from 0.0 to 24.0 at. %, on a metals basis, were made. Spark plasma sintering was used to synthesize these refractory compounds from the pure elements. Elemental and phase purity of both samples (sintered compacts and coatings) were examined using energy dispersive X-ray spectroscopy and X-ray diffraction. Microindentation was utilized to measure the Vickers hardness. X-ray diffraction results indicate that the solubility limit is below 8 at. % for Mo, Re and Zr and below 16 at. % for Cr. Above this limit both diborides (W,TM)B2 are created. Addition of transition metals caused decrease of density and increase of hardness and electrical conductivity of sintered compacts. Deposited coatings W1−xTMxBy (TM = Cr, Mo, Re, Zr; x = 0.2; y = 1.7–2) are homogenous, smooth and hard. The maximal hardness was measured for W-Cr-B films and under the load of 10 g was 50.4 ± 4.7 GPa. Deposited films possess relatively high fracture toughness and for WB2 coatings alloyed with zirconium it is K1c = 2.11 MPa m1/2.
MODELO CONCEPTUAL PARA EL DESPLIEGUE DE PUBLICIDAD UBICUA SOPORTADO EN UN ESQUEMA DE COOPERACIÓN SMART TV - SMARTPHONE

Advertising has been one of the most valuable marketing tools for years by means of a massive, wide-ranging and vertical approach between customers and advertisers. However, a new tendency known as pervasive advertising suggests an evolution of the classical concept towards a more interactive, customized, and horizontal environment that seeks to improve the impact and efficiency of conventional advertising. As a result of the support of emerging technologies related to the development of smartphones and smart TVs, there are no doubts about pervasive advertising potential and its value as a rich research field. This article introduces a conceptual model, which compiles the most relevant research areas related to pervasive computing applied to advertising supported on a smart TV – smartphone cooperation framework.
Dose calculations with the BEAM Monte Carlo code at extended SSDs

Extended Surface to Skin Distance (SSD) beam data are very useful for hemibody and total body irradiation. Monte Carlo simulation provides an alternative mechanism to calculate the dose for such treatment modalities. Comparison of the Monte Carlo results has been done with measured data of two linear accelerators of 6 MV, with results from two commercial 3D treatment-planning systems and with extrapolated data from measurements at 100 cm SSD. The results from the Monte Carlo simulations agreed with the experimental results within 1% and the PDD curves produced from the TPSs were within 2% error. The extrapolated PDD curves had a deviation of about 2%. It was found that d/sub max/ migrated towards the surface with increasing SSD which was predicted by the simulations. Also, the mean photon energy as computed by the simulation was found to be higher at extended SSD which is part of the reason why the PDDs are more penetrating for extended distances.
VR/IS Lab Virtual Actor research overview

This overview presents current research at Sandia National Laboratories in the Virtual Reality and Intelligent Simulation Lab. Into an existing distributed VR environment which we have been developing, and which provides shared immersion for multiple users, we are adding virtual actor support. The virtual actor support we are adding to this environment is intended to provide semi-autonomous actors, with oversight and high-level guiding control by a director/user, and to allow the overall action to be driven by a scenario. We present an overview of the environment into which our virtual actors will be added in Section 3, and discuss the direction of the Virtual Actor research itself in Section 4. We will briefly review related work in Section 2. First however we need to place the research in the context of what motivates it. The motivation for our construction of this environment, and the line of research associated with it, is based on a long-term program of providing support, through simulation, for situational training, by which we mean a type of training in which students learn to handle multiple situations or scenarios. In these situations, the student may encounter events ranging from the routine occurance to the rare emergency. Indeed, the appeal of such training systems is that they could allow the student to experience and develop effective responses for situations they would otherwise have no opportunity to practice, until they happened to encounter an actual occurance. Examples of the type of students for this kind of training would be security forces or emergency response forces. An example of the type of training scenario we would like to support is given in Section 4.2.
MRI Evaluation of the Brain in Children with Attention Deficit and Hyperactivity Disorder; How to Hear the Whispers Early?

Background Attention deficit and hyperactivity disorder (ADHD) is a disorder of the brain characterized by periods of inattention, hyperactivity and impulsive behavior. We aimed to evaluate the role of MRI of the brain in children with ADHD. Materials and Methods This prospective study included 100 children with clinical diagnosis of attention deficit and hyperactivity disorder according to the criteria of IDC-10. There were 79 males and 21females. Their ages ranged between 3 and 14 years old. A cohort of patients were referred from pediatric neurology unit to radiology department in El Minia University hospital, El Minia, Egypt, in the period between January 2017 and December 2017. All of them underwent MRI evaluation of the brain after approval of the ethical committee of our institution and completion of informed consent. Results MRI examination was positive in 66/100 patients and negative in 34 /100 patients. Corpus callosum dysgenesis was the most common finding in 19/66 patients, followed by temporal lobe pathology in 14/66 patients. Fronto-parietal or cerebellar atrophy was found in 11/66 patients. Tuber cinereum lesions, hippocampus sclerosis, heterotopia, pachygyria, hemimegalencephaly, Joubert syndrome and pineal cyst were a spectrum of findings among the remaining positive patients. Conclusion MRI of the brain in children with attention deficit and hyperactivity disorder will be the pivot for diagnosis. Not all patients had cerebellar or fronto-parietal atrophy as presumed before. Temporal lobe, corpus callosum and tuber cinereum must be looked for carefully. Â
Effects of Receiving Two Initial Feedings of Colostrum on the Average Daily Gain and Health of Pre-Weaning Group Housed Holstein Heifer Calves

Simple Summary High levels of bioactive factors in colostrum may benefit the growth of dairy calves when provided after the loss of macromolecule absorption ability at the gastrointestinal level. We explored the effects of feeding two feedings of colostrum instead of only one on dairy calves and analyzed the impact of growth and disease during the pre-weaning period. Calf rearing accounts for a significant expense on farms. Therefore, raising calves without additional costs becomes important economically and for improving animal welfare. Feeding calves with two feedings of colostrum did not significantly affect growth but increased total serum protein in those calves. Abstract We studied the effect on average daily gain (ADG) and health of an additional colostrum feeding to Holstein dairy heifers 12–16 h after the first colostrum feeding, provided within 2 h of birth. Calves (n = 190) with an average birth weight of 38.8 kg (29.5–52.6 kg) were randomly enrolled in blocks to either the control (CON) or colostrum (COL). The CON received 3 L of acidified pasteurized whole milk, and the COL received 3 L of pasteurized colostrum [average: 25.5 (24.7–26.4)% Brix]. Calves were group-housed, weighed, withers height measured weekly. Serum was obtained and analyzed with a% Brix refractometer. Mixed linear models were used to assess the differences in ADG, body weight, and height between the treatment and control. There was no difference in ADG between the COL and CON. However, serum % Brix was higher in the COL group (9.7%) than in the CON group (9.2%). Calves in the COL had more antibiotic treatments for respiratory diseases but fewer antibiotic treatments for otitis than the CON. In conclusion, providing an extra feeding of colostrum did not contribute to ADG of Holstein heifers during the pre-weaning period but did provide them with a higher total serum protein concentration.
Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications

The ever-growing field of materials with applications in the biomedical field holds great promise regarding the design and fabrication of devices with specific characteristics, especially scaffolds with personalized geometry and architecture. The continuous technological development pushes the limits of innovation in obtaining adequate scaffolds and establishing their characteristics and performance. To this end, computed tomography (CT) proved to be a reliable, nondestructive, high-performance machine, enabling visualization and structure analysis at submicronic resolutions. CT allows both qualitative and quantitative data of the 3D model, offering an overall image of its specific architectural features and reliable numerical data for rigorous analyses. The precise engineering of scaffolds consists in the fabrication of objects with well-defined morphometric parameters (e.g., shape, porosity, wall thickness) and in their performance validation through thorough control over their behavior (in situ visualization, degradation, new tissue formation, wear, etc.). This review is focused on the use of CT in biomaterial science with the aim of qualitatively and quantitatively assessing the scaffolds’ features and monitoring their behavior following in vivo or in vitro experiments. Furthermore, the paper presents the benefits and limitations regarding the employment of this technique when engineering materials with applications in the biomedical field.
Metodología TPACK para Capacitar al Docente en el Uso y Producción de Recursos Educativos Abiertos

The new global trend is to give knowledge through the Internet, whether through educational resources specific in knowledge areas, or through scientific publications, all within the framework of the open education movement. This implies a new conception of teaching with the use of technology, research output in open access journals, teaching strategy design in line with new trends. According to this, the following project is presented as one that has the purpose of projecting a plan of teaching training based on the TPACK model, in order to produce open educational resources, followed by scientific writing and communication that evidencing the educational practices with OER. The plan develops in three stages arranged through courses, with the aim of gradually inserting the teacher within the open educational movement, with an initial time establish to sensitize and motivate to join this new paradigm of teaching, then it will be promote the production of educational resources which will be arranged in specialized repositories. Finishing with the projection of the research and scientific publication of the academic act.
Availability of food resources and habitat structure shape the individual‐resource network of a Neotropical marsupial

Abstract Spatial and temporal variation in networks has been reported in different studies. However, the many effects of habitat structure and food resource availability variation on network structures have remained poorly investigated, especially in individual‐based networks. This approach can shed light on individual specialization of resource use and how habitat variations shape trophic interactions. To test hypotheses related to habitat variability on trophic interactions, we investigated seasonal and spatial variation in network structure of four populations of the marsupial Gracilinanus agilis in the highly seasonal tropical savannas of the Brazilian Cerrado. We evaluated such variation with network nestedness and modularity considering both cool‐dry and warm‐wet seasons, and related such variations with food resource availability and habitat structure (considered in the present study as environmental variation) in four sites of savanna woodland forest. Network analyses showed that modularity (but not nestedness) was consistently lower during the cool‐dry season in all G. agilis populations. Our results indicated that nestedness is related to habitat structure, showing that this metric increases in sites with thick and spaced trees. On the other hand, modularity was positively related to diversity of arthropods and abundance of fruits. We propose that the relationship between nestedness and habitat structure is an outcome of individual variation in the vertical space and food resource use by G. agilis in sites with thick and spaced trees. Moreover, individual specialization in resource‐rich and population‐dense periods possibly increased the network modularity of G. agilis. Therefore, our study reveals that environment variability considering spatial and temporal components is important for shaping network structure of populations.
The development of a virtual learning environment site to support year one industrial design undergraduates: a case study

This paper describes the development and initial evaluation of a site within a university virtual learning environment (VLE). This was designed to support more conventional teaching and learning on a first year undergraduate ‘design practice’ module. The first use of the VLE site in practice was evaluated from a triangulated set of qualitative data: staff observation, a student questionnaire and student reflections posted on a discussion board. The paper firstly outlines the background driving the development of the Design Practice module site on the VLE. Secondly the planning and emerging structure of the site is described. Thirdly the strategy and data collection methods to evaluate student use of the site is described. Fourthly this is followed by a discussion based on data gained. Conclusions are then drawn.
Proceedings of the 13th International Software Product Line Conference

Welcome to the Software Product Line Conference for 2009. SPLC is the premiere conference on software product line strategies. We believe the program includes topics of interest to researchers and practitioners. We have tutorials for beginners, research workshops for the most advanced researcher, and lots of content in between. Much of the content of SPLC has been supplied by you, the product line community. We thank you for your support and hope that you will continue to support future SPLCs. Volunteer to help and, above all, continue to send those great papers. We invite you to join the SPLC group on LinkedIn.com so that you can actively contribute year round and check www.splc. net periodically for new information. We have tried to be sensitive to the economic climate by seeking content about different approaches to adopting software product lines and about economic models that can illuminate the cost savings experienced by software product line organizations. With many organizations experiencing fundamental changes in business strategy, now is an excellent time to consider new product development strategies. Despite the trying economic times, we received 82 submissions to the technical program this year as well as numerous tutorial and workshop proposals. We have accepted 30 of those submissions for presentation during the technical program. Of these, a number are written by industry people and present practical information about real implementations of the software product line approach. In addition to those papers, the technical program presents keynote speakers who are recognized experts and offers working sessions that provide opportunity for conference attendees to actively participate. The tutorials, research workshops, and doctoral symposium that precede the technical program also contribute to the exciting atmosphere during the conference week.
The Limits of CD Metrology

One of the many technology decisions facing the semiconductor industry for the 32 nm node (and beyond) is the selection of the best critical dimension (CD) metrology equipment to meet the needs of process equipment suppliers and semiconductor manufacturers. Over the past three years Intel ® has fabricated a variety of test structures and performed a number of technology evaluations aimed at determining the limits of today’s CD metrology. In this paper we discuss the capability of those technologies to measure structures having dimensions representative of the 45 nm, 32 nm, and 22 nm nodes.
APPENDIX B A General‐Purpose Nonlinear Approach to the Computation of Sideband Phase Noise in Free‐Running Microwave and
 RF
 Oscillators

The harmonic balance method, used in calculating phase noise in nonlinear circuits, has some magic to it for most of us. Here is a look at our magic-lady (Figure B-1). The amplifier shown in Figure B-2 was the world’s first validation of the Compact Software Harmonic Balance Simulator, being able to correctly calculate the noise and gain of this 10 GHz amplifier. It uses measured Spice parameters. The success of the harmonic balance method was written up amongst others in Communications Quarterly, shown in Figure B-3, covering both amplifiers and oscillators. We want to look at the contribution of active devices like field effect transistors (FETs) and BIPs as well as a novel algorithm for the computation of near-carrier noise in free-running microwave oscillators by the nonlinear harmonic-balance (HB) technique [1]. The application of the HB methodology to nonlinear noise analysis is very effective, because frequency-domain analysis is well suited for describing the mechanism of noise generation in nonlinear circuits. This topic has received the interest of several research teams; however, until the first edition of this book, a rigorous treatment of noise analysis in autonomous circuits had not appeared in the technical literature. The usual approach, relying on a simple noise model of the active device and the frequency-conversion analysis, is not sufficient to describe the complex physical behavior of a noisy oscillator. Instead, we apply the following approach:
The Emerging Roles of π Subunit-Containing GABAA Receptors in Different Cancers

Cancer is one of the leading causes of death in both developed and developing countries. Due to its heterogenous nature, it occurs in various regions of the body and often goes undetected until later stages of disease progression. Feasible treatment options are limited because of the invasive nature of cancer and often result in detrimental side-effects and poor survival rates. Therefore, recent studies have attempted to identify aberrant expression levels of previously undiscovered proteins in cancer, with the hope of developing better diagnostic tools and pharmaceutical options. One class of such targets is the π-subunit-containing γ-aminobutyric acid type A receptors. Although these receptors were discovered more than 20 years ago, there is limited information available. They possess atypical functional properties and are expressed in several non-neuronal tissues. Prior studies have highlighted the role of these receptors in the female reproductive system. New research focusing on the higher expression levels of these receptors in ovarian, breast, gastric, cervical, and pancreatic cancers, their physiological function in healthy individuals, and their pro-tumorigenic effects in these cancer types is reviewed here.