Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognostic efficacy and prognostic factors of TACE plus TKI with ICIs for the treatment of unresectable hepatocellular carcinoma: A retrospective study

Hepatocellular carcinoma (HCC) remains a global challenge due to its high morbidity and mortality rates as well as poor response to treatment. Local combined systemic therapy is widely used in the treatment of unresectable hepatocellular cancer (uHCC). This retrospective study was to investigate the prognostic effect and prognostic factors of transcatheter arterial chemoembolization (TACE) plus tyrosine kinase inhibitors (TKI) with immune checkpoint inhibitors (ICIs) in the treatment of uHCC. A retrospective analysis of 171 patients with uHCC was performed in our hospital from April 27, 2015 to October 18, 2021. According to different treatment options, patients were divided into TACE group (n=45), TACE+TKI group (n=76) and TACE+TKI+ICIs group (n=50). In this study, we found that, the median overall survival (mOS) of TACE+TKI+ICIs group was significantly better than TACE+TKI group and TACE group [24.1 (95% CI 15.1-33.1) months vs 14.9 (95% CI 10.7-19.1) months vs 11.4 (95% CI 8.4-14.5) months, hazard ratio (HR) 0.62; 95% CI 0.47-0.81; P=0.002]. A visible difference in the median progression-free survival (mPFS) interval between the groups was discovered [10.6 (95% CI6.5-14.7) months in TACE+TKI+ICIs group vs. 6.7 (95% CI 5.5-7.9) months in the TACE+TKI group vs. 6 (95% CI 2.3-9.7) months in the TACE group (HR 0.66; 95% CI 0.53-0.83; P<0.001)]. The objective response rates (ORR) in the TACE group, TACE+TKI group, and TACE+TKI+ICIs group were 31.1%, 35.5%, and 42%, and the disease control rate (DCR) were 51.1%, 65.8%, and 80%. There were no adverse events (AEs) of arthralgia, diarrhea, rash, and pruritus in the TACE group. The incidence of grade 3 AEs (Hypertension) in the TACE+TKI+ICIs group was significantly higher than that in TACE+TKI and TACE groups (28% vs 17.1% vs 6.7%, P=0.024), and secondly, the morbidity of rash and pruritus in the TACE+TKI+ICIs group was apparently higher than that in the TACE+TKI group (P<0.05). Multivariate analysis showed that ECOG-PS 2 (HR=2.064, 95%CI 1.335-3.191, P=0.001), Hepatitis B virus (HR=2.539, 95%CI 1.291-4.993, P=0.007), AFP≥400 ng/ml (HR= 1.72, 95%CI 1.12-2.643, P=0.013), neutrophil-lymphocyte ratio (NLR) ≥2.195 (HR=1.669, 95%CI 1.073-2.597, P=0.023) were independent risk factors for OS in uHCC patients. So, TACE+TKI+ICIs therapy can prolong the OS and improve the prognosis of patients effectively, with a well-characterized safety profile.
Editorial: Quality of life in young cochlear implant recipients: Are there controlling factors and regional differences?

COPYRIGHT © 2022 Huber, Lee, Langereis and Vermeulen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Editorial: Quality of life in young cochlear implant recipients: Are there controlling factors and regional di erences?
Interplay between rhizospheric Pseudomonas chlororaphis strains lays the basis for beneficial bacterial consortia

Pseudomonas chlororaphis (Pc) representatives are found as part of the rhizosphere-associated microbiome, and different rhizospheric Pc strains frequently perform beneficial activities for the plant. In this study we described the interactions between the rhizospheric Pc strains PCL1601, PCL1606 and PCL1607 with a focus on their effects on root performance. Differences among the three rhizospheric Pc strains selected were first observed in phylogenetic studies and confirmed by genome analysis, which showed variation in the presence of genes related to antifungal compounds or siderophore production, among others. Observation of the interactions among these strains under lab conditions revealed that PCL1606 has a better adaptation to environments rich in nutrients, and forms biofilms. Interaction experiments on plant roots confirmed the role of the different phenotypes in their lifestyle. The PCL1606 strain was the best adapted to the habitat of avocado roots, and PCL1607 was the least, and disappeared from the plant root scenario after a few days of interaction. These results confirm that 2 out 3 rhizospheric Pc strains were fully compatible (PCL1601 and PCL1606), efficiently colonizing avocado roots and showing biocontrol activity against the fungal pathogen Rosellinia necatrix. The third strain (PCL1607) has colonizing abilities when it is alone on the root but displayed difficulties under the competition scenario, and did not cause deleterious effects on the other Pc competitors when they were present. These results suggest that strains PCL1601 and PCL1606 are very well adapted to the avocado root environment and could constitute a basis for constructing a more complex beneficial microbial synthetic community associated with avocado plant roots.
Cardia function-preserving surgery and anti-reflux anastomotic method after proximal gastrectomy for gastric cancer: Current status and future perspectives

The incidence and mortality of gastric cancer ranked 5th and 3rd worldwide, respectively, in 2018, and the incidence of gastroesophageal junction adenocarcinoma increased over the past 40 years. Radical resection and lymph node dissection is the preferred treatment for gastric cancer. Proximal gastrectomy or total gastrectomy is usually performed for gastroesophageal junction adenocarcinoma and upper gastric cancer. Owing to the resection of the cardia structures, the incidence of reflux esophagitis increases significantly after proximal gastrectomy and total gastrectomy, resulting in poor postoperative quality of life. To reduce the incidence of reflux esophagitis and improve patients’ postoperative quality of life, various methods to preserve the function of the cardia or to perform anti-reflux reconstruction have emerged. In this manuscript, we systematically introduced the advantages and problems of various anti-reflux anastomotic method after proximal gastrectomy, and cardia-preserving gastrectomy including endoscopic resection (ER), local gastrectomy by gastroscopy combined with laparoscopy, segmental gastrectomy, subtotal gastrectomy, and cardia-preserving radical gastrectomy. Cardia-preserving radical gastrectomy has the advantage of more thorough lymph node dissection and wider indications than those for subtotal gastrectomy. However, the clinical efficacy of cardia-preserving radical gastrectomy requires verification in prospective and controlled clinical trials. Cardia-preserving radical gastrectomy is a promising approach as one of the more reasonable anti-reflux surgeries.
Expression patterns of maize PIP aquaporins in middle or upper leaves correlate with their different physiological responses to drought and mycorrhiza

Here we report the effect of Rhizophagus irregularis on maize leaf expression of six plasma membrane aquaporin isoforms from PIP1 and PIP2 subfamilies under severe drought development and recovery. The novelty of our study is the finding that leaf-specific mycorrhizal regulation of aquaporins is dependent on the position of the leaf on the shoot and changes in parallel with the rate of photosynthesis and the stomatal response to drought. The transcripts were isolated from the upper third (L3) or ear (L5) leaf, which differed greatly in physiological response to stress within each symbiotic variant. Aquaporins expression in upper L3 leaves appeared to be largely not sensitive to drought, regardless of symbiotic status. In contrast, L5 leaf of non-mycorrhizal plants, showed strong down-regulation of all PIPs. Mycorrhiza, however, protected L5 leaf from such limitation, which under maximal stress was manifested by 6-fold and circa 4-fold higher transcripts level for PIP1s and PIP2s, respectively. Distinct expression patterns of L3 and L5 leaves corresponded to differences in key parameters of leaf homeostasis - stomatal conductance, photosynthetic rates, and accumulation of ABA and SA as phytohormonal indicators of drought stress. In result symbiotic plants showed faster restoration of photosynthetic capability, regardless of leaf position, which we recognize as the hallmark of better stress tolerance. In summary, arbuscular mycorrhiza alleviates short-term drought effects on maize by preventing the down-regulation of plasma membrane aquaporins within middle leaves, thereby affecting stomatal conductance.
Recalibration of myoelectric control with active learning

Introduction Improving the robustness of myoelectric control to work over many months without the need for recalibration could reduce prosthesis abandonment. Current approaches rely on post-hoc error detection to verify the certainty of a decoder's prediction using predefined threshold value. Since the decoder is fixed, the performance decline over time is inevitable. Other approaches such as supervised recalibration and unsupervised self-recalibration entail limitations in scaling up and computational resources. The objective of this paper is to study active learning as a scalable, human-in-the-loop framework, to improve the robustness of myoelectric control. Method Active learning and linear discriminate analysis methods were used to create an iterative learning process, to modify decision boundaries based on changes in the data. We simulated a real-time scenario. We exploited least confidence, smallest margin and entropy reduction sampling strategies in single and batch-mode sample selection. Optimal batch-mode sampling was considered using ranked batch-mode active learning. Results With only 3.2 min of data carefully selected by the active learner, the decoder outperforms random sampling by 4–5 and ~2% for able-bodied and people with limb difference, respectively. We observed active learning strategies to systematically and significantly enhance the decoders adaptation while optimizing the amount of training data on a class-specific basis. Smallest margin and least confidence uncertainty were shown to be the most supreme. Discussion We introduce for the first time active learning framework for long term adaptation in myoelectric control. This study simulates closed-loop environment in an offline manner and proposes a pipeline for future real-time deployment.
PDX1 is the cornerstone of pancreatic β-cell functions and identity

Diabetes has been a worldwide healthcare problem for many years. Current methods of treating diabetes are still largely directed at symptoms, aiming to control the manifestations of the pathology. This creates an overall need to find alternative measures that can impact on the causes of the disease, reverse diabetes, or make it more manageable. Understanding the role of key players in the pathogenesis of diabetes and the related β-cell functions is of great importance in combating diabetes. PDX1 is a master regulator in pancreas organogenesis, the maturation and identity preservation of β-cells, and of their role in normal insulin function. Mutations in the PDX1 gene are correlated with many pancreatic dysfunctions, including pancreatic agenesis (homozygous mutation) and MODY4 (heterozygous mutation), while in other types of diabetes, PDX1 expression is reduced. Therefore, alternative approaches to treat diabetes largely depend on knowledge of PDX1 regulation, its interaction with other transcription factors, and its role in obtaining β-cells through differentiation and transdifferentiation protocols. In this article, we review the basic functions of PDX1 and its regulation by genetic and epigenetic factors. Lastly, we summarize different variations of the differentiation protocols used to obtain β-cells from alternative cell sources, using PDX1 alone or in combination with various transcription factors and modified culture conditions. This review shows the unique position of PDX1 as a potential target in the genetic and cellular treatment of diabetes.
The station scientist: Examining the impact of race and sex of broadcast meteorologists on credibility, trust, and information retention

Broadcast meteorologists hold a set of skills unique in a newsroom. Not only must a broadcast meteorologist utilize communication skills similar to that of a newscaster, they are also typically versed in some physical science. In addition, the field of meteorology has an unfortunate disparity when examining job statistics as they relate to race and biological sex. Generally speaking, men outnumber women in broadcast television positions three to one, and minorities are often outnumbered or excluded from coverage altogether. Drawing on Uses and Gratifications and Media System Dependency Theory, this project examined the effects of race and biological sex on the audience perceptions of forecaster trust, credibility, and information retention. Two experiments were conducted, and analysis of variance was utilized to examine the hypotheses and research questions. The first experiment tested the manipulations of forecaster race and sex in the form of a mock weather hit – using a student sample. The results generally suggest that there are mixed findings for the effects of forecaster race and sex on the dependent variables of trust, credibility, and information retention. The second experiment tested the same two manipulations from experiment one on a non-student sample. The results are discussed in terms of how individuals may perceive forecasters given their race, sex, or degree level, and the potential implications for processing information or forming attitudes and decisions based off this behavior.
Restoring bigcone Douglas-fir post-fire in drought-stricken Southern California: Assessing the effects of site choice and outplanting strategies

Introduction Forest restoration is a powerful tool to combat the dual threats of drought and fire, both of which have been increasing in frequency and severity in recent years in the Western United States. The hard-hit region of Southern California is home to the endemic bigcone Douglas-fir, Pseudotsuga macrocarpa (Vasey), whose abundance and range have been impacted by multiple large fires within the last two decades. Methods To better understand the ecology of these trees, and thereby improve the potential for restoration in light of predicted future conditions, we outplanted 1,728 seedlings into burned areas with varying levels of pre-planting fire severity and proximity to water (near canyon bottom and upslope). Within each planting area, seedlings were planted into one of four microhabitats; under conspecifics, under the codominant oak species [Quercus chrysolepis (Liebm)], in the open (no woody canopy), or in the open within a microsite feature such as a log, rock or a small shaded hole. At each site and within each microhabitat, half the seedlings were treated with oak-soil amendments (soil from under the oak) and half with spring watering (4 months after planting). To better understand the influence of outplanting conditions, we tracked the survival of the seedlings over the next two years. Results and discussion Short-term (March to June) survivorship following planting was quite high and the most significant die-off of seedlings occurred during the first dry season (June to November) despite strong droughts in the second and third dry seasons. Overall, only 7.3% (127 of 1,728) of seedlings survived. Seedling success depended strongly on the microhabitat and summer watering, though not in necessarily intuitive ways. Seedlings that received supplemental water during the first summer did worse than unwatered seedlings. The most successful microhabitats for planting were open sites with microsite features and sites underneath canyon live oak, while sites under mature bigcone Douglas-firs had the lowest rates of survival. Position on the slope had no effect on outcomes and soil amendment had a weak negative effect on seedling survival.
Editorial: Women in animal behavior and welfare: 2021

COPYRIGHT © 2022 Guelfi and Kemper. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Editorial: Women in animal behavior and welfare: 2021
Identification of an immune-related gene prognostic index for predicting prognosis, immunotherapeutic efficacy, and candidate drugs in amyotrophic lateral sclerosis

Rationale and objectives Considering the great insufficiency in the survival prediction and therapy of amyotrophic lateral sclerosis (ALS), it is fundamental to determine an accurate survival prediction for both the clinical practices and the design of treatment trials. Therefore, there is a need for more accurate biomarkers that can be used to identify the subtype of ALS which carries a high risk of progression to guide further treatment. Methods The transcriptome profiles and clinical parameters of a total of 561 ALS patients in this study were analyzed retrospectively by analysis of four public microarray datasets. Based on the results from a series of analyses using bioinformatics and machine learning, immune signatures are able to be used to predict overall survival (OS) and immunotherapeutic response in ALS patients. Apart from other comprehensive analyses, the decision tree and the nomogram, based on the immune signatures, were applied to guide individual risk stratification. In addition, molecular docking methodology was employed to screen potential small molecular to which the immune signatures might response. Results Immune was determined as a major risk factor contributing to OS among various biomarkers of ALS patients. As compared with traditional clinical features, the immune-related gene prognostic index (IRGPI) had a significantly higher capacity for survival prediction. The determination of risk stratification and assessment was optimized by integrating the decision tree and the nomogram. Moreover, the IRGPI may be used to guide preventative immunotherapy for patients at high risks for mortality. The administration of 2MIU IL2 injection in the short-term was likely to be beneficial for the prolongment of survival time, whose dosage should be reduced to 1MIU if the long-term therapy was required. Besides, a useful clinical application for the IRGPI was to screen potential compounds by the structure-based molecular docking methodology. Conclusion Ultimately, the immune-derived signatures in ALS patients were favorable biomarkers for the prediction of survival probabilities and immunotherapeutic responses, and the promotion of drug development.
Experimental assessment of fractal scale similarity in turbulent flows. Part 2. Higher-dimensional intersections and non-fractal inclusions

Results from an earlier experimental assessment of fractal scale similarity in one-dimensional spatial and temporal intersections in turbulent flows are here extended to two- and three-dimensional spatial intersections. Over 25000 two-dimensional (2562) intersections and nearly 40 three-dimensional (2563) intersections, collectively representing more than 2.3 billion data points, were analysed using objective statistical methods to determine which intersections were as fractal as stochastically scale-similar fractal gauge sets having the same record length. Results for the geometry of Sc [Gt ]1 scalar isosurfaces and the scalar dissipation support span the range of lengthscales between the scalar and viscous diffusion scales λD and λν. The present study finds clear evidence for stochastic fractal scale similarity in the dissipation support. With increasing intersection dimension n, the data show a decrease in the fraction of intersections satisfying the criteria for fractal scale similarity, consistent with the presence of localized non-fractal inclusions. Local scale similarity analyses on three-dimensional (643) intersections directly show such intermittent non-fractal inclusions with characteristic lengthscale comparable to λν. These inclusions lead to failure of the relation among codimensions Dn≡D−(3−n) when applied to simple average dimensions, which has formed the basis for most previous assessments of fractal scale-similarity. Unlike the dissipation support geometry, scalar isosurface geometries from the same data were found not to be as fractal as fractional Brownian motion gauge sets over the range of scales examined.
Characterization of plasma membrane proteins in stylosanthes leaves and roots using simplified enrichment method with a nonionic detergent

Plant plasma membranes (PMs) play an important role in maintaining the stability of the intracellular environment and exchanging information with the external environment. Therefore, deciphering dynamics of PM proteome provides crucial information for elucidating cellular regulation in response to diverse stimuli. In the study, we developed a simplified method for enriching PM proteins in leaf and root tissues of a tropical forage Stylosanthes by combining differential centrifugation and Brij-58 treatment. Both immunoblot analysis and mass spectrometry demonstrated that the representation and abundance of PM proteins were increased in the enrichment fraction, and the contamination of other organellar proteins was decreased. A total of 426 and 388 proteins were predicted to be PM proteins in leaves and roots, respectively. Functional analysis classified these PM proteins into six major categories (transporter, enzyme, receptor, membrane structure protein, vesicular trafficking and chaperone), and orthologs of many PM proteins regulating the responses to abiotic and biotic stresses have been detected. In addition, the sequence analysis, subcellular localization and gene expression analyses of a newly identified receptor-like kinase, SgRKL1, has been performed. Together, these results show that the simplified PM enrichment method can be successfully applied to different plant tissue types and to study the dynamics of PM proteome of Stylosanthes in response to multiple stresses.
Reading motivation, self-regulated reading strategies and English vocabulary knowledge: Which most predicted students’ English reading comprehension?

This study explored how reading motivation, self-regulated reading strategies and English vocabulary knowledge influenced students’ English reading comprehension simultaneously in one model. A total of 543 students from five universities in Southern China completed a reading motivation questionnaire, a reading strategy questionnaire, two vocabulary knowledge tests, and a reading comprehension test. Multiple regression analysis results showed that reading efficacy and enjoyment, and vocabulary knowledge (i.e., both vocabulary breadth and depth) significantly predicted reading comprehension. When students were grouped into high, average, and low achievers on the reading test, monitoring strategies and vocabulary depth were found to significantly predict reading comprehension for the high achievers.