Miracle-dz/UniFAR-FTUs huggingface dataset:
Tobamovirus infection aggravates gray mold disease caused by Botrytis cinerea by manipulating the salicylic acid pathway in tomato

Botrytis cinerea is the causative agent of gray mold disease, and infects more than 1400 plant species, including important crop plants. In tomato, B. cinerea causes severe damage in greenhouses and post-harvest storage and transport. Plant viruses of the Tobamovirus genus cause significant damage to various crop species. In recent years, the tobamovirus tomato brown rugose fruit virus (ToBRFV) has significantly affected the global tomato industry. Most studies of plant-microbe interactions focus on the interaction between the plant host and a single pathogen, however, in agricultural or natural environments, plants are routinely exposed to multiple pathogens. Here, we examined how preceding tobamovirus infection affects the response of tomato to subsequent infection by B. cinerea. We found that infection with the tobamoviruses tomato mosaic virus (ToMV) or ToBRFV resulted in increased susceptibility to B. cinerea. Analysis of the immune response of tobamovirus-infected plants revealed hyper-accumulation of endogenous salicylic acid (SA), upregulation of SA-responsive transcripts, and activation of SA-mediated immunity. Deficiency in SA biosynthesis decreased tobamovirus-mediated susceptibility to B. cinerea, while exogenous application of SA enhanced B. cinerea symptoms. These results suggest that tobamovirus-mediated accumulation of SA increases the plants’ susceptibility to B. cinerea, and provide evidence for a new risk caused by tobamovirus infection in agriculture.
Case report: Improvement in refractory functional seizures, depression, and quality of life with ketamine-assisted therapy

Functional seizures, a primary subtype of functional neurological disorder (FND), are a known cause of serious neurological disability with an increasing awareness of their impact amongst the neuroscience community. Situated at the intersection of neurology and psychiatry, FND is characterized by a range of alterations in motor, sensory or cognitive performance, such as abnormal movements, limb weakness, and dissociative, seizure-like episodes. Functional seizures are known, in part, to have psychological underpinnings; however, the lack of effective and consistent treatment options requires research and novel approaches to better understand the etiology, diagnosis and what constitutes a successful intervention. Ketamine, a selective blocker of the N-methyl-D-aspartate receptor, has a well-established safety and efficacy profile. In recent years, ketamine-assisted therapy has shown increasing potential for treating a broad range of psychiatric conditions, building on its demonstrated rapid-acting antidepressant effects. Here we present a 51-year-old female with refractory daily functional seizures leading to significant disability and a medical history significant for major depressive disorder (MDD) and posttraumatic stress disorder (PTSD). After unsuccessful treatment attempts, the patient underwent a novel protocol with ketamine-assisted therapy. After 3 weeks of ketamine-assisted therapy followed by 20 weeks of intermittent ketamine treatment and ongoing integrative psychotherapy, the patient’s seizures were significantly reduced in frequency and severity. She experienced significant improvements in depressive symptoms and functional ability scores. To our knowledge, this is the first reported case describing improvement in functional seizures following ketamine-assisted therapy. While rigorous studies are needed, this case report encourages further investigation of ketamine-assisted therapy for functional seizures and other functional neurological symptoms.
Preventive health examinations: protocol for a prospective cross-sectional study of German employees aged 45 to 59 years (Ü45-check)

Objective Early identification of health-related risk factors is of great importance for maintaining workability. Screening examinations can help to detect diseases at an early stage and provide more needs-based recommendations. This study aims (1) to assess the individual need for prevention or rehabilitation based on preventive health examinations compared to a questionnaire survey, (2) to assess the results of the preventive health examinations compared to the Risk Index – Disability Pension (RI-DP), (3) to assess the results of the questionnaire survey compared to the RI-DP, (4) to assess the general health status of the sample (target population > 1,000) in German employees aged 45–59, (5) to identify the most common medical conditions. A further study question aims, and (6) to investigate the general health status of the specific occupational groups. Methods Comprehensive diagnostics including medical examination, anamnesis, anthropometric measurements, bioelectrical impedance analysis (BIA), handgrip strength, resting electrocardiogram (ECG), resting blood pressure, pulse wave velocity (PWV), and laboratory blood analyses added by a questionnaire are conducted. The research questions are analyzed in an exploratory manner. Results and conclusion We expect that the results will allow us to formulate recommendations regarding screening for prevention and rehabilitation needs on a more evidence-based level. Clinical Trial Registration: DRKS ID: DRKS00030982.
Editorial: Immunometabolism and therapeutic targeting of aggressive cancers

COPYRIGHT © 2023 Ždralević and Pouysségur. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. TYPE Editorial PUBLISHED 12 June 2023 DOI 10.3389/fonc.2023. 1226078
Impact of plaque and luminal morphology in balloon angioplasty of the femoropopliteal artery: an intravascular ultrasound analysis

Objective To assess the effect of plaque and luminal morphologies in balloon angioplasty of femoropopliteal lesions using intravascular ultrasound (IVUS). Methods This retrospective, observational study analyzed 836 cross-sectional images using IVUS, from 35 femoropopliteal arteries of patients who underwent endovascular treatment between September 2020 and February 2022. Pre- and post-balloon angioplasty images were matched per 5 mm. Post-balloon angioplasty images were grouped into successful (n = 345) and unsuccessful (n = 491) groups. Plaque and luminal morphologies (such as severity of calcification, vascular remodeling, and plaque eccentricity) were extracted before the balloon angioplasty procedure to identify the predictors of unsuccessful balloon angioplasty. Additionally, 103 images with severe dissection were analyzed using IVUS and angiography. Results In univariate analyses, the predictive factors for unsuccessful balloon angioplasty were vascular remodeling (p < .001), plaque burden (p < .001), lumen eccentricity (p < .001), and balloon/vessel ratio (p = .01). Predictive factors for severe dissections were the guidewire route (p < .001) and balloon/vessel ratio (p = .04). In multivariate analysis, the predictive factors for unsuccessful balloon angioplasty included lumen eccentricity (odds ratio [OR]: 3.99, 95% confidence interval [CI]: 1.28–12.68, p = .02) and plaque burden (OR: 1.03, 95% CI: 1.02–1.04; p < .001). For severe dissections, the independent risk factor was an eccentric guidewire route (OR: 2.10, 95% CI: 1.22–3.65, p = .01). Conclusion High plaque burden and luminal eccentricity were risk factors for failed femoropopliteal artery balloon angioplasty. Additionally, eccentric guidewire routes predicted severe dissection.
Response of cetaceans to fluctuations of pelagic fish stocks and environmental conditions within the Celtic Sea ecosystem

Inshore waters off the south coast of Ireland are an important foraging area for a range of cetacean species. Some of the main prey species of these cetaceans are herring and sprat, two economically valuable fish species in the region. The Celtic Sea herring stock suffered a marked decline in 2013. The present study aimed to investigate potential changes in the ecosystem associated to the herring decline and to determine the potential impacts on predators. Here we analyzed sightings information of common dolphins, fin, minke, humpback and unidentified whale species, acoustic data of herring and sprat, and a range of environmental variables mainly derived from satellites. Firstly, we characterized spatio-temporal patterns in the relative abundance of predator and prey species, and environmental variables, and compared periods before and since the herring decline. Since the 2013 herring decline, (i) the herring stock has mainly concentrated in south-eastern coastal waters and southern offshore Irish waters, (ii) sprat density has increased, (iii) chlorophyll concentration has decreased, (iv) sea surface temperature has risen, and (v) the euphotic layer has extended deeper. Secondly, we modelled the effects of prey density and environmental conditions on the relative abundance and distribution of cetaceans, as well as the effects of environmental conditions on prey density, between 2005-2018 by applying Hurdle Generalized Additive Models. The models for herring and sprat support the idea that these species have different environmental relationships, for example herring tended to be found in shallower waters than was the case for sprat. The presence and relative abundance of common dolphins were significantly affected by both environmental conditions and herring density, whereas whale species presence and relative abundance were found to be correlated with sea surface temperature and prey density. The model results suggest differences in prey choice among whale species. Understanding the dynamic relationships between predators, prey and the environment is important to inform an ecosystem-based approach to fisheries management.
A semi purified hydroalcoholic fraction from Caesalpinia bonduc seeds causes ergosterol biosynthesis inhibition in Candida albicans resulting in cell membrane damage

Candida species are currently developing resistance to prevailing commercially available drugs, which raises an instantaneous need to discover novel antifungals. To cope with this shocking situation, phytochemicals are the richest, safest, and most potent source of excellent antimicrobials with broad-spectrum activity. The aim of the current study is to explore the anticandidal potential of the various fractions purified from the hydroalcoholic extract of C. bonduc seed. Out of five fractions purified from the hydroalcoholic extract, fraction 3 (Fr. 3) recorded the best activity against C. albicans (8 μg/mL) and thus this species was chosen for further mechanism of action studies. The phytochemical examination reveals that Fr. 3 was found to contain steroids and triterpenoids. This was further supported by LC-QTOF-MS and GCMS analyses. Our findings show that Fr. 3 targets the ergosterol biosynthesis pathway in C. albicans by inhibiting the lanosterol 14-α demethylase enzyme and downregulating expression of its related gene ERG11. Molecular docking outcomes disclosed favorable structural dynamics of the compounds, implying that the compounds present in Fr. 3 would be able to successfully bind to the lanosterol 14-α demethylase, as evidenced by the docked compounds’ strong interaction with the target enzyme’s amino acid residues. Considering virulence factors, the Fr. 3 recorded significant antibiofilm activity as well as germ-tube reduction potential. Furthermore, Fr. 3 enhances the production of intracellular reactive oxygen species (ROS). This suggests that the antifungal activity of Fr. 3 was associated with membrane damage and the induction of ROS production, resulting in cell death. Fluorescence microscopic analysis of PI stained Candida further showed changes in the plasma membrane permeability, which causes severe loss of intracellular material and osmotic balance. This was demonstrated by the potassium ion leakage and release of genetic materials. Finally, the erythrocyte lysis assay confirmed the low cytotoxicity of Fr. 3. Both in silico and in vitro results suggest that Fr. 3 has the potential to propel forward novel antifungal drug discovery programmes.
Comparison of anterior and posterior approaches in Treating odontoid fractures: a meta-analysis and systematic review

Background Odontoid fractures account for 15%–20% of cervical injuries. Although the operation methods vary in different types, the superiority of overall outcomes of the anterior approach (AA) and posterior approach (PA) in treating odontoid fractures still remains controversial. Thus, a meta-analysis was performed comparing AA and PA for these fractures. Methods The relevant studies were searched in PubMed/MEDLINE, Cochrane Library, EMBASE, China Biological Medicine (CBM), and Wanfang Database from the onset of conception to June 2022. Prospective or retrospective comparative studies on AA and PA for odontoid fractures were screened, referring to fusion rates (primary outcomes), complications, and postoperative mortality rates. A meta-analysis of the primary outcomes and a systematic review of other outcomes were performed; the procedure was conducted with Review Manager 5.3. Results Twelve articles comrising 452 patients were included, and all publications were retrospective cohort studies. The average postoperative fusion rate was 77.5 ± 17.9% and 91.4 ± 13.5% in AA and PA, respectively, with statistical significance [OR = 0.42 (0.22, 0.80), P = 0.009]. Subgroup analysis showed a difference in fusion rates between AA and PA in the elderly group [OR = 0.16 (0.05, 0.49), P = 0.001]. Five articles referred to postoperative mortality, and the mortality rates of AA (5.0%) and PA (2.3%) showed no statistical difference (P = 0.148). Nine studies referred to complications, with a rate of 9.7%. The incidence of complications in AA and PA groups was comparable (P = 0.338), and the incidence of nonfusion and complications was irrelevant. The prevalent cause of death was myocardial infarction. The time and segmental movement retention of AA were possibly superior to those of PA. Conclusion AA may be superior in regard to operation time and motion retention. There was no difference in complications and mortality rates between the two approaches. The posterior approach would be preferred in consideration of the fusion rate.
A Data Valuation Model to Estimate the Investment Value of Platform Companies: Based on Discounted Cash Flow

As both investment attraction and mergers and acquisitions targeting information technology and platform companies are becoming more important in the digital-centric economic environment, interest in valuing corporate data assets is increasing. Accordingly, among the income approaches used in business valuation, this study presents a data valuation model based on discounted cash flow. This model is expected to be useful for corporate investment decision-making. The assumptions used in this study for the estimation of data income include intangible asset value, exclude net asset value, and data attribution is centered on technology, human resources, and market factors. In particular, data attribution accounts comprise ordinary data research and development, data labor costs, and data advertising expenses. Data costs were divided into those incurred during collection, storage, curation, analysis, and utilization. Financial statements and related data from a real estate information platform operator over three years were collected and used to simulate the data valuation model. The simulation reveals that the operator possesses KRW 472.6 billion in data assets. Ultimately, the data valuation model developed in this study can contribute to strengthening platform operators’ investment attraction, guaranteeing financial sustainability, and transparency and data assetization.
The Global Resonance of Human Rights: What Google Trends Can Tell Us

W here is the human rights discourse most resonant? We use aggregated cross-national Google search data to test two divergent accounts of why human rights appeal to some populations but not others. The top-down model predicts that nationwide interest in human rights is attributable mainly to external factors such as foreign direct investment, transnational NGO campaigns, or international legalization, whereas the bottom-up model highlights the importance of internal factors such as economic growth and persistent repression. We find more evidence for the latter model: not only is interest in human rights more concentrated in the Global South, but the discourse is also most resonant where people face regular state violence. In drawing these inferences, this article confronts high-level debates over whether human rights will remain relevant in the future, and whether the discourse still animates counter-hegemonic modes of resistance. The answer to both questions, our research suggests, is “ yes. ”
Sparse inference using approximate message passing

The Variational Garrote is a promising new approach for sparse solutions of ill-posed linear inverse problems (Kappen and Gomez, 2012). We reformulate the prior of the Variational Garrote to follow a simple Binomial law and assign a Beta hyper-prior on the parameter. With the new prior the Variational Garrote, we show, has a wide range of parameter values for which it at the same time provides low test error and high retrieval of the true feature locations. Furthermore, the new form of the prior and associated hyper-prior leads to a simple update rule in a Bayesian variational inference scheme for its hyperparameter. As a second contribution we provide evidence that the new procedure can improve on cross-validation of the parameters and we find that the new formulation of the prior outperforms the original formulation when both are cross-validated to determine hyperparameters.
A Visual Speech Intelligibility Benefit Based on Speech Rhythm

This study examined whether visual speech provides speech-rhythm information that perceivers can use in speech perception. This was tested by using speech that naturally varied in the familiarity of its rhythm. Thirty Australian English L1 listeners performed a speech perception in noise task with English sentences produced by three speakers: an English L1 speaker (familiar rhythm); an experienced English L2 speaker who had a weak foreign accent (familiar rhythm), and an inexperienced English L2 speaker who had a strong foreign accent (unfamiliar speech rhythm). The spoken sentences were presented in three conditions: Audio-Only (AO), Audio-Visual with mouth covered (AVm), and Audio-Visual (AV). Speech was best recognized in the AV condition regardless of the degree of foreign accent. However, speech recognition in AVm was better than AO for the speech with no foreign accent and with a weak accent, but not for the speech with a strong accent. A follow-up experiment was conducted that only used the speech with a strong foreign accent, under more audible conditions. The results also showed no difference between the AVm and AO conditions, indicating the null effect was not due to a floor effect. We propose that speech rhythm is conveyed by the motion of the jaw opening and closing, and perceivers use this information to better perceive speech in noise.
Lecture 8/9: Global convergence of Gradient Descent

One would expect that locating the global minimum when training a neural network via gradient descent would be a very difficult task. However, surprisingly, in practice we find that the optimization error does go to zero while training, indicating that these models do generalize quite well and reach the global minima. [1] Approaches such as landscape analysis that analyze the geometry of the objective function fail to sufficiently demonstrate why gradient descent attains the global minimum.
Two-Sample Tests for Inhomogeneous Random Graphs in Lr Norm: Optimality and Asymptotics

In this paper we study the two-sample problem for inhomogeneous Erd˝os-R´enyi (IER) random graph models in the L r norm, in the high-dimensional regime where the number of samples is smaller or comparable to the size of the graphs. Given two symmetric matrices P, Q ∈ [0 , 1] n × n (with zeros on the diagonals), the two-sample problem for IER graphs (with respect to the L r norm (cid:107) · (cid:107) r ) is to test the hypothesis H 0 : P = Q versus H 1 : (cid:107) P − Q (cid:107) r ≥ ε , given a sample of m graphs from the respective distributions. In this paper, we obtain the optimal sample complexity for testing in the L r norm, for all integers r ≥ 1 . We also derive the asymptotic distribution of the optimal tests under H 0 and develop a method for consistently estimating their variances. This allows us to efﬁciently implement the optimal tests with precise asymptotic level and establish their asymptotic consistency. We validate our theoretical results by numerical experiments for various natural IER models.
Un résultat sur le comportement asymptotique des solutions de systèmes dynamiques monotones

In this Note, we consider a general class of dynamical semi-systems which have a first integral. In this setting, we can show that the asymptotic behaviour of solutions depends only on the first integral On considere une classe assez generale de semi-systemes dynamiques monotones ayant une integrale premiere monotone. Dans ce cadre, on montre que le comportement asymptotique des solutions ne depend que de l'integrale premiere
Curve interactions in R^2: An analytical and stochastical approach

In the last few years a lot of work has been done in the investigation of Brownian motion with point interaction(s) in one and higher dimensions. Roughly speaking a Brownian motion with point interaction is nothing else than a Brownian motion whose generator is disturbed by a measure supported in just one point. The purpose of the present work is the introducing of curve interactions of the two dimensional Brownian motion for a closed curve \(\mathcal{C}\). We will understand a curve interaction as a self-adjoint extension of the restriction of the Laplacian to the set of infinitely often continuously differentiable functions with compact support in \(\mathbb{R}^{2}\) which are constantly 0 at the closed curve. We will give a full description of all these self-adjoint extensions. In the second chapter we will prove a generalization of Tanaka's formula to \(\mathbb{R}^{2}\). We define \(g\) to be a so-called harmonic single layer with continuous layer function \(\eta\) in \(\mathbb{R}^{2}\). For such a function \(g\) we prove \begin{align} g\left(B_{t}\right)=g\left(B_{0}\right)+\int\limits_{0}^{t}{\nabla g\left(B_{s}\right)\mathrm{d}B_{s}}+\int\limits_{0}^{t}\eta\left(B_{s}\right)\mathrm{d}L\left(s,\mathcal{C}\right) \end{align} where \(B_{t}\) is just the usual Brownian motion in \(\mathbb{R}^{2}\) and \(L\left(t,\mathcal{C}\right)\) is the connected unique local time process of \(B_{t}\) on the closed curve \(\mathcal{C}\). We will use the generalized Tanaka formula in the following chapter to construct classes of processes related to curve interactions. In a first step we get the generalization of point interactions in a second step we get processes which behaves like a Brownian motion in the complement of \(\mathcal{C}\) and has an additional movement along the curve in the time- scale of \(L\left(t,\mathcal{C}\right)\). Such processes do not exist in the one point case since there we cannot move when the Brownian motion is in the point. By establishing an approximation of a curve interaction by operators of the form Laplacian \(+V_{n}\) with "nice" potentials \(V_{n}\) we are able to deduce the existence of superprocesses related to curve interactions. The last step is to give an approximation of these superprocesses by a sytem of branching particles. This approximation gives a better understanding of the related mass creation.