Miracle-dz/UniFAR-FTUs huggingface dataset:
Perspectives on benefit of early and prereperfusion hypothermia by pharmacological approach in stroke

Stroke kills or disables approximately 15 million people worldwide each year. It is the leading cause of brain injury, resulting in persistent neurological deficits and profound physical handicaps. In spite of over 100 clinical trials, stroke treatment modalities are limited in applicability and efficacy, and therefore, identification of new therapeutic modalities is required to combat this growing problem. Poststroke oxidative damage and lactic acidosis are widely-recognized forms of brain ischemia/reperfusion injury. However, treatments directed at these injury mechanisms have not been effective. In this review, we offer a novel approach combining these well-established damage mechanisms with new insights into brain glucose handling. Specifically, emerging evidence of brain gluconeogenesis provides a missing link for understanding oxidative injury and lactate toxicity after ischemia. Therefore, dysfunctional gluconeogenesis may substantially contribute to oxidative and lactate damage. We further review that hypothermia initiated early in ischemia and before reperfusion may ameliorate gluconeogenic dysfunction and subsequently provide an important mechanism of hypothermic protection. We will focus on the efficacy of pharmacologically assisted hypothermia and suggest a combination that minimizes side effects. Together, this study will advance our knowledge of basic mechanisms of ischemic damage and apply this knowledge to develop new therapeutic strategies that are desperately needed in the clinical treatment of stroke.
Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer

Quercetin belongs to the broader category of polyphenols. It is found, in particular, among the flavonols, and along with kaempferol, myricetin and isorhamnetin, it is recognized as a foreign substance after ingestion in contrast to vitamins. Quercetin occurs mainly linked to sugars with the most common compounds being quercetin-3-O-glucoside or as an aglycone, especially in the plant population. The aim of this review is to present a recent bibliography on the mechanisms of quercetin absorption and metabolism, bioavailability, and antioxidant and the clinical effects in diabetes and cancer. The literature reports a positive effect of quercetin on oxidative stress, cancer, and the regulation of blood sugar levels. Moreover, research-administered drug dosages of up to 2000 mg per day showed mild to no symptoms of overdose. It should be noted that quercetin is no longer considered a carcinogenic substance. The daily intake of quercetin in the diet ranges 10 mg–500 mg, depending on the type of products consumed. This review highlights that quercetin is a valuable dietary antioxidant, although a specific daily recommended intake for this substance has not yet been determined and further studies are required to decide a beneficial concentration threshold.
Evaluation of Clostridium difficile Toxin B Results by Polymerase Chain Reaction from Stool Specimens

Objective: Clostridium difficile is a Gram-positive, anaerobic, spore-forming bacterium that spreads via the fecal-oral route and causes asymptomatic carriage or mild diarrheal diseases such as pseudomembranous enterocolitis. C. difficile is the commonest cause of nosocomial and antibiotic-associated diarrhea in North America and Europe. It can produce two toxins called A and B. Strains producing toxins can lead to a more serious disease picture that causes megacolon, perforation or septic shock. The use of molecular methods with high specificity and SONUÇLARININ DEĞERLENDİRİLMESİ method. The data obtained are interpreted as positive, negative or invalid results. Results: A total of 109 samples were tested. 66 (61%) of the stool samples belonged to male and 43 (39%) female patients. Twenty-five (23%) of the patients were under the age of 18 and 36 (33%) under the age of 18 years. Of the samples, 26 (24%) were from intensive care units, 60 (55%) were from services and 23 (21%) were from polyclinics. It was found 109 from stool samples. 9 (8%), C. difficile PCR test toxin B positive, 100 (92%) negative. Conclusion: The most important cause of nosocomial diarrhea is C. difficile . The main predisposing factor of infection is the use of antibiotics. Prophylaxis or even one dose of antibiotic therapy may be sufficient for the development of C. difficile infection. Rapid and accurate diagnosis by PCR is important for early initiation yaş
Research on Emotion Analysis and Psychoanalysis Application With Convolutional Neural Network and Bidirectional Long Short-Term Memory

This study mainly focuses on the emotion analysis method in the application of psychoanalysis based on sentiment recognition. The method is applied to the sentiment recognition module in the server, and the sentiment recognition function is effectively realized through the improved convolutional neural network and bidirectional long short-term memory (C-BiL) model. First, the implementation difficulties of the C-BiL model and specific sentiment classification design are described. Then, the specific design process of the C-BiL model is introduced, and the innovation of the C-BiL model is indicated. Finally, the experimental results of the models are compared and analyzed. Among the deep learning models, the accuracy of the C-BiL model designed in this study is relatively high irrespective of the binary classification, the three classification, or the five classification, with an average improvement of 2.47% in Diary data set, 2.16% in Weibo data set, and 2.08% in Fudan data set. Therefore, the C-BiL model designed in this study can not only successfully classify texts but also effectively improve the accuracy of text sentiment recognition.
Aging and Microbiome in the Modulation of Vaccine Efficacy

From infancy through to old age, the microbiome plays an important role in modulating the host-immune system. As we age, our immune system and our gut microbiota change significantly in composition and function, which is linked to an increased vulnerability to infectious diseases and a decrease in vaccine responses. Our microbiome remains largely stable throughout adulthood; however, aging causes a major shift in the composition and function of the gut microbiome, as well as a decrease in diversity. Considering the critical role of the gut microbiome in the host-immune system, it is important to address, prevent, and ameliorate age-related dysbiosis, which could be an effective strategy for preventing/restoring functional deficits in immune responses as we grow older. Several factors, such as the host’s genetics and nutritional state, along with the gut microbiome, can influence vaccine efficacy or reaction. Emerging evidence suggests that the microbiome could be a significant determinant of vaccine immunity. Physiological mechanisms such as senescence, or the steady loss of cellular functions, which affect the aging process and vaccination responses, have yet to be comprehended. Recent studies on several COVID-19 vaccines worldwide have provided a considerable amount of data to support the hypothesis that aging plays a crucial role in modulating COVID-19 vaccination efficacy across different populations.
Karaktererősségek a nyelvórán – Pozitív pszichológiai intervenciók az egyetemi nyelvoktatási gyakorlatban

A nyelvoktatás módszertanának nagy kihívása, hogy hogyan tudjuk a nyelvtanulók képességeit minél eredményesebben kibontakoztatni, köztük a jelenleg az oktatásban és a munkaerőpiacon is fókuszban lévő XXI. századi képességeket. A pozitív pszichológia képviselői rámutattak, hogy a pszichés jóllét hatékonyabb tanulási folyamatot eredményez (Seligman et al., 2009), így vélhetően a pozitív pszichológia elméleti elgondolásai és gyakorlati intervenciói az oktatás, így a nyelvoktatás területén is érvényesek lehetnek. A karaktererősségek fejlesztésére szolgáló pozitív pszichológiai intervenciók egy jól alkalmazható keretrendszert jelentenek, amelyek pozitívan hatnak az egyéni, illetve csoportos jóllét összetevőire, például az élettel való elégedettségre, a belső motivációra, a stresszkezelésre, a megküzdésre, a feladat iránti elkötelezettségre, a csoportban való együttműködésre és a rezilienciára (Cable et al., 2015; Harzer-Ruch, 2015; Meyers & Van Woerkom, 2016). A tanulmány célja, hogy szakirodalmi áttekintéssel bemutassa a pozitív pszichológia eszme- áramlatának főbb irányvonalait és az ebből kiinduló pozitív pedagógiai hatásrendszer alapgondola- tait, majd megvizsgálja a pozitív pszichológia egyik központi fogalmát, a karaktererősségeket és az ezekre épülő, az oktatásban alkalmazható intervenciókat, amelyeknek hatékonysága kutatásokkal igazolt. A tanulmány kitér arra is, hogy a karaktererősségekre építő pozitív pszichológiai interven- ciókat hogyan lehet a nyelvoktatásban, a nyelvórai gyakorlatban alkalmazni, a középiskolás-egyete- mista korosztály viszonylatában.
IMPLEMENTASI METODE VECTOR SPACE MODEL UNTUK DETEKSI EMOSI MENGGUNAKAN DATA TEKS TWITTER

Makin maraknya penggunaan jejaring sosial dalam hal ini adalah Twitter, maka menjadikan aplikasi tersebut sebagai big data atau kumpulan data yang sangat besar. Secara tidak langsung penggunaan Twitter akan memberikan dampak, baik itu dampak positif maupun negatif. Salah satu dampak negatif yang terjadi adalah penyalahgunaan dari pengguna, dimana yang awal mulanya digunakan untuk ajang saling berbagi aktivitas keseharian, sekarang berganti untuk promosi kegiatan prostitusi yang berakhir dengan sebuah kejahatan pembunuhan, sehingga muncul penelitian tentang Twitter Forensic untuk menyelidiki kasus seseorang berdasarkan data-data yang terdapat pada Twitter. Penelitian ini adalah sangat penting, karena dengan mengetahui emosi seseorang berdasarkan data posting yang ada di akun Twitter nya, sehingga dapat menambahkan data penunjang untuk kegiatan Twitter Forensic yang memang belum dilakukan sampai saat ini. Beberapa jenis emosi yang dipergunakan pada penelitian ini adalah senang, sedih, dan marah. Salah satu cara untuk mengetahui emosi adalah dengan memanfaatkan kumpulan data Twitter sebagai data latih dan data uji untuk mengklasifikasi emosi pengguna yang dilihat dari status atau tweet yang dipublikasikan menggunakan text mining. Sistem dibuat untuk mengklasifikasikan tweet berdasarkan jenis emosinya. Sebelum mempelajari tweet untuk membentuk model pembelajaran, tweet melalui tahap pemrosesan awal (preproccessing) yang terdiri dari case folding (pengubahan huruf besar menjadi kecil), tokenizing (pemisahan per-kata), dan filtering (karakter dan stoplist). Kemudian menghitung bobot tiap kata dengan metode TF-IDF(Term Frequency- Inverse Document Frequency), serta mengukur tingkat similaritas menggunakan metode VSM (Vector Space Model). Tiga kali pengujian dilakukan dengan total data latih 225 tweet, sebanyak 45 data latih pada pengujian tahap pertama, 75 data latih tahap kedua, dan 105 data latih untuk tahap ketiga. Hasilnya menunjukkan akurasi klasifikasi emosi tweet berkisar antara 65% – 75%.
Improved the coconut shell biochar properties for bio-electricity generation of microbial fuel cells from synthetic wastewater

A microbial fuel cell (MFC) is a green device that utilizes chemical energy in organic materials to generate electricity. The low-cost electrode used in this study was made from agricultural waste, coconut shells. The electrochemical properties were improved by combining oxidizing agents and microwave heating processes. The modified coconut shell electrode outperformed virgin biochar by 30.89-fold (230.13±10.11 m2/g). The maximum open-circuit voltage, current density, and power density are respectively 995.00±5.00 mV, 841.67±14.43 mA/m2, and 283.42±9.67 mW/m2. This study demonstrated that modified coconut shell biochar could be used as a low-cost alternative electrode for electricity generation.
Confirmatory Analysis of the Indonesian Version of the Centrality Religiosity Scale

Religiosity in studies of sociology and psychology of religion is generally measured by using a scale constructed for a particular religious tradition. The Centrality of Religiosity Scale (CSR) developed by Huber & Huber (2012) is a religiosity measure scale that can be used by adherents of different religions. Research on religiosity in heterogeneous Indonesian society requires an instrument that can be used by various religious adherents. The purpose of this study is to translate and test the reliability and validity of CSR from English to Indonesian. The translated CRS is a 15-item version that is divided into 5 dimensions, namely ideology, knowledge, experience, public worship, and private worship. This study was conducted in 2 stages. It began with translating the English version of the CRS-15 measuring instrument into Indonesian which was carried out using the back forward translation method from Brislin (1980). The next stage was to test the psychometric appropriateness of CRS-15 using confirmation analysis which was conducted on data from 328 research respondents who were recruited using a convenient sampling technique. The results of statistical analysis showed satisfactory reliability results (α=.787). In addition, it was also indicated that the Indonesian version of the CRS consists of 14 items and could be used in studies of religiosity in Indonesian-speaking communities.
Ciencia cognitiva y neuromarketing: investigación académica, tecnologías emergentes y desafíos profesionales

Analizar la eficacia de las comunicaciones que llevan a cabo los anunciantes es el primer paso para conocer si se están alcanzando los objetivos de comunicación previstos. Cada persona se enfrenta, diariamente, a miles de mensajes persuasivos y, durante décadas, se ha utilizado una gran variedad de técnicas de medición cuya principal limitación es su dependencia de la voluntad y capacidad de los consumidores para describir sus niveles de atención, emociones, preferencias y futuros comportamientos de compra. Es a finales del siglo XX cuando nace un paradigma que aporta nuevos métodos para profundizar y avanzar en el conocimiento de los mecanismos de la persuasión, especialmente en aquellos relacionados con la influencia de los aspectos emocionales del relato, y en cómo contribuyen en nuestros cambios cognitivos; este paradigma, aplicado al ámbito de la mercadotecnia, implica adaptar las técnicas de la neurociencia a las comunicaciones de marketing, dando lugar al neuromarketing. El objetivo de este monográfico es profundizar en el conocimiento de esta disciplina que, a pesar de contar con poco más de dos décadas de historia, dispone ya de un extenso corpus científico fundamentado en investigaciones empíricas.
Pengaruh E-WOM, Product Quality, Dan Price Terhadap Brand Image Melalui Perceived Value

Pada masa sekarang ini, perkembangan ekonomi juga sangat mempengaruhi gaya hidup masyarakat. Gaya hidup yang berkembang, akan mengakibatkan hobi yang berkembang pula seperti hobi berpetualang di alam bebas. Fenomena ini dimanfaatkan oleh perusahaan untuk memproduksi serta menyediakan kelengkapan kegiatan alam, salah satunya yaitu Eiger. Penelitian ini dilakukan bertujuan untuk mengetahui pengaruh Electronic Word Of Mouth (E-WOM), Product Quality, dan Price terhadap Brand Image melalui Perceived Value pada Produk Eiger (Penjualan secara online). Penelitian ini merupakan penelitian kuantitatif dengan menyebarkan kuesioner kepada 115 responden yang merupakan pengguna Produk Eiger, pernah melakukan pembelian Produk Eiger secara online, dan konsumen yang mengikuti instagram @EigerAdventure. Analisis data pada penelitian ini menggunakan analisis PLS-SEM dengan SmartPLS 3.0. Hasilnya adalah variabel Electronic Word Of Mouth (E-WOM), Product Quality, dan Price dinyatakan berpengaruh secara positif dan signifikan terhadap Perceived Value. Kemudian untuk variabel Product Quality, Price, dan Perceived Value juga dinyatakan berpengaruh secara positif dan signifikan terhadap Brand Image. Sedangkan variabel Electronic Word Of Mouth (E-WOM) dinyatakan berpengaruh secara positif namun tidak signifikan terhadap Brand Image.
Growth Differentiation Factor-15 as a Biomarker for Sarcopenia in Patients With Chronic Obstructive Pulmonary Disease

Purpose Sarcopenia is an important factor contributing to comorbidities in patients with chronic obstructive pulmonary disease (COPD) and is an independent risk factor for increased mortality. The diagnostic process for sarcopenia requires specific equipment and specialized training and is difficult procedurally. A previous study found that GDF15 levels are associated with skeletal muscle mass and function in patients with COPD. However, whether circulating GDF15 levels can be used for the prediction of sarcopenia in patients with COPD is unknown. Methods This study included 235 patients with stable COPD who were divided into a development set (n = 117) and a validation set (n = 118), and we followed the definition of sarcopenia as defined by the guidelines from the Asian Working Group for Sarcopenia. Serum concentrations of GDF15 were measured using an enzyme-linked immunosorbent assay (ELISA), and construction of a nomogram and decision curve analysis were performed using the R package “rms. ” Results In this study, serum GDF15 levels were negatively associated with skeletal muscle mass (r = –0.204, p = 0.031), handgrip strength (r = –0.274, p = 0.004), quadriceps strength (r = –0.269, p = 0.029), and the thickness (r = –0.338, p < 0.001) and area (r = –0.335, p < 0.001) of the rectus femoris muscle in patients with COPD. Furthermore, the serum levels of GDF15 in patients with sarcopenia were significantly higher than those in controls. Importantly, serum levels of GDF15 could effectively predict sarcopenia in patients with COPD based on the development set (AUC = 0.827) and validation set (AUC = 0.801). Finally, a nomogram model based on serum GDF15 levels and clinical features showed good predictive ability (AUC > 0.89) in the development and validation sets. Conclusion Serum GDF15 levels could be used to accurately and easily evaluate sarcopenia in patients with COPD.
Mycorrhizal status of Plantago coronopus L. in relation to edaphic parameters in a coastal dune of Oran

<p><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">La présente étude a été menée dans le but de contribuer à une meilleure compréhension de l'adaptation des psammo-halophytes à leurs environnements hostiles à travers la détermination de leur statut mycorhizien. </span><span style="vertical-align: inherit;">Il s'agissait de l'évaluation du statut mycorhizien de </span></span><em><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">Plantago </span></span></em> <em><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">coronopu</span></span></em><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">s L. en relation avec les paramètres édaphiques de sa rhizosphère dans une dune du littoral oranais. </span><span style="vertical-align: inherit;">Des échantillons de sol rhizosphérique et de racines ont été prélevés sur trois sites situés sur les dunes de Bomo-plage, à l'ouest d'Oran. </span><span style="vertical-align: inherit;">Les paramètres de colonisation mycorhizienne de la plante et les paramètres physico-chimiques du substrat ont été déterminés. </span><span style="vertical-align: inherit;">Les résultats ont montré que le substrat avait une texture sablo-limoneuse, il était légèrement salin, très pauvre en eau et en nutriments, avec une forte charge de calcaire total et une faible teneur en carbone organique et en azote total. </span><span style="vertical-align: inherit;">Les racines ont été colonisées par des champignons de type mycorhizes arbusculaires avec une fréquence moyenne élevée (61,34%). </span><span style="vertical-align: inherit;">Les résultats de l'analyse en composantes principales ont révélé que les paramètres mycorhiziens étaient positivement corrélés avec la salinité du sol, le carbone organique et la matière organique, l'azote total et le limon. </span><span style="vertical-align: inherit;">Cependant, la corrélation entre les paramètres mycorhiziens et le pH,</span></span></p>
Chaotic Motion of a Charged Particle around a Weakly Magnetized Schwarzschild Black Hole Containing Cosmic String

在它被另一个粒子或光子踢以后，我们讨论原来围着在最深处的稳定的圆形的轨道包含宇宙的绳的一个微弱地吸引的黑洞正在转的一个控告的粒子将逃跑到无穷的条件。 我们发现踢的粒子的运动是混乱的。 有不同起始的光线的速度的踢的控告的粒子的批评逃跑精力和速度被获得。
Binary ethanol-water solvents affect betalain contents and health-promoting properties of red Celosia argentea inflorescence extracts

The present work aimed to compare the betalain profiles and contents in the red inflorescence of Celosia argentea extract obtained using different ethanol-water ratios. The impact of betalain content on the health-promoting properties was also evaluated. Freeze-dried inflorescence powder was extracted three times with aqueous-ethanol (0, 20, 40, 60, and 80% (v/v) ethanol). The highest total betacyanin content was found in the 40 and 60% aqueous-ethanolic extracts. Total phenolic content and antioxidant activities of the extracts increased with increasing ethanol concentration. The antioxidant activities measured by oxygen radical absorbance capacity (ORAC) assay of the 60 and 80% aqueous-ethanolic extracts were significantly higher than that of ascorbic acid. The IC50 of α-glucosidase inhibitory activities of all extracts were comparable to that of acarbose. Phenolics were the major responsible compounds for antioxidant (r = 0.975, p < 0.01 by ORAC assay), α-amylase (r = -0.725, p < 0.01), and lipase (r = 0.607, p < 0.05) inhibitory activities, whilst betacyanins corresponded to α-glucosidase inhibitory activities (r = 0.627, p < 0.05). The 60% aqueous-ethanolic extract was superior to the others in terms of colour, phytochemical contents, and health-promoting activities. These extracts can be utilised as natural food colorant, functional ingredients, and nutraceuticals.
Association of long and short interpregnancy intervals with maternal outcomes

Background: Interpregnancy interval (IPI) is spacing between live birth and beginning a new pregnancy. Both long and short IPIs have been associated with adverse maternal outcomes. There is paucity in the Indian literature regarding the impact of IPI on maternal outcomes. Materials and Methodology: The cross-sectional study was conducted in the Department of Obstetrics and Gynecology, King George's Medical University, Lucknow, from July 2019 to June 2020. Women with previous abortions, previous stillbirth, nulliparity, or multiple pregnancies were excluded. A pre-structured pro forma was used for demographic details. IPI was categorized as <6 months, 6 to <24 months, 24 to <60 months, and 60 months. Maternal outcomes were studied, and odds ratios were calculated. Results: There were 6984 deliveries in the period. A total of 4812 women were enrolled after following the inclusion and exclusion criteria. Of 4812 women, 142 (2.9%) had IPI <6 months, 3336/4812 women (69.3%) had IPI 6 to <24 months, 1144/4812 women (23.7%) had IPI 24 to <60 months, and 3.9% women (190/4812) had IPI ≥60 months. High risk of fetal malposition (OR 3.84), fetal growth restriction (OR 2.06), and hypertension (OR 1.86) were seen in women with short IPI <6 months. Women with longer IPI (≥ 60 months) had higher chances of preterm labor (OR 3.82), oligoamnios (OR 2.54), gestational diabetes (OR 2.19), and anemia (OR 1.45) Conclusion: Three-fourths of women had IPI less than 24 months recommended as minimum interval by WHO. Efforts are needed to increase awareness and availability of contraceptive choices for postpartum women to ensure adequate spacing.