Miracle-dz/UniFAR-FTUs huggingface dataset:
Fire Management in the Inter Galatic Interface or 30 Years of Fire Management at Merritt Island National Wildlife Refuge/Kennedy Space Center, Florida

Prescribed burning is essential on Merritt Island National Wildlife Refuge. Not only is it needed to manage the volatile fuels, but also to manage the complex system of fire maintained habitats found here. Fire management on the Refuge presents unique challenges. In addition to the restraints to prescribed burning that are common to many prescribed burning programs, Refuge fire managers must also consider the special needs of an operational space port. By using an active program of education, demonstration and negotiation with the Space Center, the Refuge has been able to maintain a prescribed burning program that has reduced the detrimental effects of unwanted wildland fires when they occur.
Evaluation of CIN2/3 Lesion Regression in GynTect® DNA Methylation-Marker-Negative Patients in a Longitudinal Study

Simple Summary Precancerous cervical lesions, especially among young women, are frequently cleared by the immune system. Consequently, immediate surgical treatment is not mandatory and patients are monitored closely for up to 24 months. To avoid anxiety and to allow for a more individualized treatment, molecular markers that could predict the outcome of the lesion would be desirable. Women with a high risk of progression could be identified earlier. In this study, we could show that the majority of lesions that were negative for the cancer-associated methylation markers comprising the test GynTect® have regressed over time. Abstract Cervical intraepithelial neoplasia (CIN) grade 2/3 has a high spontaneous regression rate, especially among women ≤29 years of age. To reduce overtreatment, reliable prognostic biomarkers would be helpful. The main aim of this study was to analyze the negative predictive value of the methylation marker panel GynTect® for lesion regression. In this prospective, multicenter, longitudinal observational proof-of-concept study, women aged ≤29 years with histologically confirmed CIN2 (n = 24) or CIN3 (n = 36) were closely monitored without treatment for up to 24 or 12 months, respectively. The outcome was either regression, persistence, or progression of the lesion. For each patient, a single baseline sample (V0) for cytology, hrHPV detection and methylation analysis was taken. In a primary analysis, the negative predictive value (NPV) of a GynTect®-negative test result at V0 for regression was determined. We tested the null hypothesis NPV ≤ 70% against the alternative hypothesis NPV ≥ 90%. Twelve of the eighteen GynTect®-negative CIN2 patients showed regression (NPV = 67%, 90% CI 44–85%, p = 0.53). Of the 27 GynTect®-negative CIN3 lesions, 15 regressed (NPV = 56%, 90% CI 38–72%, p = 0.92). Although the majority of GynTect®-negative lesions regressed, the postulated NPV of ≥90% was not observed. Thus, the clinical relevance for an implementation of the GynTect® assay for patients undergoing watchful waiting remains questionable. Further studies with longer observation periods should be undertaken.
Measures of reliability in high frequency longitudinal white matter multi-shell diffusion and inhomogeneous magnetization transfer database

Longitudinal imaging studies are widely used to capture and characterize progressive brain changes. However, evaluation of the reproducibility and the variation of measures in MRI is crucial to reliably detect or predict brain changes with quantitative MRI measures. Using the coefficient of variation and intraclass correlation, we evaluated the reproducibility of diffusion and myelin-based MRI measures from a multi-shell diffusion and inhomogeneous magnetization transfer MRI dataset of twenty healthy adults, each with five MRI acquisitions over six months. Moderate to high reproducibility of diffusion and myelin measures is observed within white matter tracks of interests.
Comparative Analysis of Physicochemical Properties and Storability of a New Citrus Variety, Yellowball, and Its Parent

Although numerous citrus varieties have recently been developed to enhance their quality, information on their quality characteristics is limited. We assessed the quality characteristics of Yellowball, a novel citrus variety, by evaluating its appearance, storability, sensory properties, functionality, and metabolite profiles and then comparing these characteristics with those of its parent varieties, Haruka and Kiyomi. The metabolite profiles between the citrus varieties differed significantly, resulting in distinct physicochemical and functional qualities. The storability of Yellowball was significantly increased compared with that of its parent varieties owing to its strong antifungal activity and unique peel morphology, including the stoma and albedo layers. While we did not investigate the volatile compounds, overall functional activities, and detailed characteristics of each metabolite, our data provide valuable insights into the relationship between citrus metabolites, peel morphology, physicochemical properties, and storability, and demonstrate the potential of Yellowball as a promising variety in the citrus industry.
Downward flux of particulate dimethylsulphoniopropionate (dmspp) in the tropical open-ocean

We report results from free-drifting sediment trap deployments at 200 m depth which enable measurement of the diel variations in the downward flux of detrital particulate dimethylsulphoniopropionate (DMSPp) over periods of 24-72 hours in three contrasting trophic regimes of the tropical northeastern Atlantic Ocean off Mauritania. The source of DMSPp was the phytoplankton living in surficial water layers. The three regimes exhibited similar strong diel cycles, the nocturnal fluxes being up to 100-fold lower than the daytime fluxes. High (or low) detrital DMSPp, fluxes were associated with high (or low) numbers of pteropods trapped inside the sampling cups. Thus, contamination of sinking material is likely to have occurred, promoting an overestimate of the daytime fluxes. It is concluded that the transport of DMSPp at depths deeper than 200 m is strongly influenced by the downward migration of pteropods during the daylight: hours. This mode of transport is shown to be a general process in tropical waters for accelerating DMSPp sedimentation. Under these oceanic and experimental conditions the daily DMSPp flux at 200 m accounted for only about 0.1 % of the DMSPp standing stock. Hence, the DMSPp downward flux is likely to have a minor influence in the upper ocean budget of DMSPp.
Skeletal muscle cell protein dysregulation highlights the pathogenesis mechanism of myopathy-associated p97/VCP R155H mutations

p97/VCP, a hexametric member of the AAA-ATPase superfamily, has been associated with a wide range of cellular protein pathways, such as proteasomal degradation, the unfolding of polyubiquitinated proteins, and autophagosome maturation. Autosomal dominant p97/VCP mutations cause a rare hereditary multisystem disorder called IBMPFD/ALS (Inclusion Body Myopathy with Paget’s Disease and Frontotemporal Dementia/Amyotrophic Lateral Sclerosis), characterized by progressive weakness and subsequent atrophy of skeletal muscles, and impacting bones and brains, such as Parkinson’s disease, Lewy body disease, Huntington’s disease, and amyotrophic lateral ALS. Among all disease-causing mutations, Arginine 155 to Histidine (R155H/+) was reported to be the most common one, affecting over 50% of IBMPFD patients, resulting in disabling muscle weakness, which might eventually be life-threatening due to cardiac and respiratory muscle involvement. Induced pluripotent stem cells (iPSCs) offer an unlimited resource of cells to study pathology’s underlying molecular mechanism, perform drug screening, and investigate regeneration. Using R155H/+ patients’ fibroblasts, we generated IPS cells and corrected the mutation (Histidine to Arginine, H155R) to generate isogenic control cells before differentiating them into myotubes. The further proteomic analysis allowed us to identify differentially expressed proteins associated with the R155H mutation. Our results showed that R155H/+ cells were associated with dysregulated expression of several proteins involved in skeletal muscle function, cytoskeleton organization, cell signaling, intracellular organelles organization and function, cell junction, and cell adhesion. Our findings provide molecular evidence of dysfunctional protein expression in R155H/+ myotubes and offer new therapeutic targets for treating IBMPFD/ALS.
Who Owns Scotland

This is a comprehensive account and analysis of landownership in Scotland. Drawing on a wide range of sources, it lists the owners of Scotland, and analyzes the current pattern of landownership and how it has evolved over the centuries. Illustrated with maps of all 33 Scottish counties, the book documents the ownership of 75 per cent of Scotland, listing not only the legal owners but also the people behind the companies and trusts which own the country. It details the extent of land held by overseas interests, the aristocracy, companies, charitable bodies and the state. This book is designed to inform and provoke. It reviews the history and politics of land reform in Scotland, analyzes the extent of available information on this controversial subject, and provides a critique of the existing ownership pattern and land tenure pattern. The book concludes by proposing a radical programme of land reform for a future Scottish parliament.
Impact of Quantitative Computed Tomography-Based Analysis of Abdominal Adipose Tissue in Patients with Lymphoma

Quantitative abdominal adipose tissue analysis is important for obtaining information about prognosis and clinical outcomes on a wide array of diseases. In recent years, the effects of abdominal adipose tissue compartments in patients with lymphoma and the changes in their distribution after therapies have been studied. This information could facilitate the improvement of therapies in patients with lymphoma, to prevent or treat both visceral obesity and sarcopenia. Opportunistic analysis of body composition on computed tomography (CT) images might contribute to the improvement of patient management and clinical outcomes together with implementation of targeted patient-tailored therapies. The purpose of this literature review is to describe the role of CT to evaluate abdominal adipose tissue quantity and distribution in patients with lymphoma.
Factors affecting the adoption of destination management systems by stakeholders: Proposal of an explanatory model

Despite Destination Management Systems’ (DMSs) important role in management and promotion of destinations, the research on factors influencing their adoption is scarce. This paper aims to empirically analyse the influence of a comprehensive range of factors on DMS adoption and propose a model. A questionnaire survey was applied to tourism players in a Portuguese region (Centro) without DMSs. Results were subsequently analysed using Principal Component Analyses and multiple linear regressions. The study corroborates the findings of previous research. However, it also provides new insights, revealing a positive influence of available resources and strategic vision of stakeholders on the stakeholders’ willingness to adopt DMSs and a negative impact of alternative web platforms and inexistence of complementary DMSs, on adoption intentions, being proposed the model—DMSs’ Adoption Model (DeMSAM).
Effect of Dietary Patterns on Inflammatory Bowel Disease: A Machine Learning Bibliometric and Visualization Analysis

Aims: This study aimed to analyze the related research on the influence of dietary patterns on IBD carried out over the past 30 years to obtain the context of the research field and to provide a scientific basis and guidance for the prevention and treatment of IBD. Methods: The literature on the effects of dietary patterns on inflammatory bowel disease published over the past three decades was retrieved from the Web of Science Core Collection (WoSCC) database. CiteSpace, VOSviewer, the R software (version 4.3.0) bibliometrix package, the OALM platform, and other tools were used for the analyses. Results: The growth of scientific papers related to this topic can be divided into two stages: before and after 2006. Overall, the growth of the relevant literature was in line with Price’s literature growth curve. Subrata Ghosh and Antonio Gasbarrini are the authors with the highest academic influence in the field, and Lee D. ’s research results are widely recognized by researchers in this field. Among the 72 countries involved in the study, the United States contributed the most, while China developed rapidly with regard to research being carried out in this area. From a regional perspective, countries and institutions in North America, Europe, and East Asia have made the most significant contributions to this field and have the closest cooperation. Among the 1074 articles included in the study, the most influential ones tended to consider the mechanism of the effect of dietary patterns on IBD from the perspective of the microbiome. Multiple tools were used for keyword analysis and mutual verification. The results showed that NF-κB, the Mediterranean diet, fatty acids, fecal microbiota, etc., are the focus and trends of current research. Conclusions: A Mediterranean-like dietary pattern may be a good dietary habit for IBD patients. Carbohydrates, fatty acids, and inulin-type fructans are closely related to IBD. Fatty acid, gut microbiota, NF-κB, oxidative stress, and endoplasmic reticulum stress are the hot topics in the study of the effects of dietary patterns on IBD and will be emerging research trends.
Targeting Epithelium Dysfunction and Impaired Nasal Biofilms to Treat Immunological, Functional, and Structural Abnormalities of Chronic Rhinosinusitis

Chronic rhinosinusitis (CRS) with (CRSwNP) or without (CRSsNP) nasal polyps is a prevalent and heterogeneous disorder existing as a spectrum of clinical conditions with complex underlying pathomechanisms. CRS comprises a broad syndrome characterized by multiple immunological features involving complex interactions between the genes, the microbiome, host- and microbiota-derived exosomes, the epithelial barrier, and environmental and micromilieu exposures. The main pathophysiological feature is an epithelial barrier disruption, accompanied by microbiome alterations and unpredictable and multifactorial immunologic overreactions. Extrinsic pathogens and irritants interact with multiple epithelial receptors, which show distinct expression patterns, activate numerous signaling pathways, and lead to diverse antipathogen responses. CRSsNP is mainly characterized by fibrosis and mild inflammation and is often associated with Th1 or Th17 immunological profiles. CRSwNP appears to be associated with moderate or severe type 2 (T2) or Th2 eosinophilic inflammation. The diagnosis is based on clinical, endoscopic, and imaging findings. Possible CRS biomarkers from the peripheral blood, nasal secretions, tissue biopsies, and nasally exhaled air are studied to subgroup different CRS endotypes. The primary goal of CRS management is to maintain clinical control by nasal douching with isotonic or hypertonic saline solutions, administration of nasal and systemic steroids, antibiotics, biologic agents, or, in persistent and more severe cases, appropriate surgical procedures.
Optimizing Neurology Inpatient Documentation: A Pilot Study of a Novel Discharge Documentation EHR Tool

Background and Purpose Clinical documentation of patient acuity is a major determinant of payer reimbursement. This project aimed to improve case mix index (CMI) by incorporating a novel electronic health record (EHR) discharge documentation tool into the inpatient general neurology service at the University of California, Los Angeles (UCLA) Medical Center. Methods We used data from Vizient AMC Hospital: Risk Model Summary for Clinical Data Base (CBD) 2017 to create a discharge diagnosis documentation tool consisting of dropdown menus to better capture relevant secondary diagnoses and comorbidities. After implementation of this tool, we compared pre- (July 2017-June 2019) and post-intervention (July 2019-June 2021) time periods on mean expected length of stay (LOS) and mean CMI with two sample T-tests and the percentage of encounters classified as having Major Complications/Comorbidities (MCC), with Complication/Comorbidity (CC), and without CC/MCC with tests of proportions. Results Mean CMI increased significantly from 1.2 pre-intervention to 1.4 post-intervention implementation (P < .01). There was a pattern of increased MCC percentages for “Bacterial infections,” “Other Disorders of Nervous System”, “Multiple Sclerosis,” and “Nervous System Neoplasms” diagnosis related groups post-intervention. Conclusions This pilot study describes the creation of an innovative EHR discharge diagnosis documentation tool in collaboration with neurology healthcare providers, the clinical documentation improvement team, and neuro-informaticists. This novel discharge diagnosis documentation tool demonstrates promise in increasing CMI, shifting diagnosis related groups to a greater proportion of those with MCC, and improving the quality of clinical documentation.
Dialectical Medicine: Z Syndrome and Use of Pathological Substances, The Clinical Case

Since the beginning of humanity man develops without stimulation for internal consciousness, although technological evolution grows in a linear sense, the human mind remains stagnant, exchanging the ancient human slavery for the mental slavery of money and fear. Z Syndrome was described in September 2022 as a family neuroadaptation disease, dearly childhood, as central dysfunction to biological family asynchrony, with multiple neuroendocrine, neuro epigenetic alterations, associated with chronic filial hypodopaminergic state, all unconscious, in which family disease is harmful among family members. This is a dysfunction common to every human being, and Z Syndrome has initial dopaminergic pathophysiology, and is connected to other medical areas. The dialectic function of the reality of the religious, of the doctor, of the legal professional, of a political leader, who now has the choice between the biological truth of his diagnoses, of his families, and of his countries, whether a disease, disorder or just dysfunction, directly influences the collective future. All children to this day, are growing and developing neuro adapted, without biological family synchrony, and without real free will. Statistics will hardly solve studies of the human mind, which is always limited to linearity without clinical coding in the field of medicine. Dissecting intimately the love of attachment, the sublimation of charity and gaining fluid intelligence, is the result of the unique and REAL CHANGE, which is the treatment of Z Syndrome. The reflection and evaluation of the work performed to any addition should be revaluated, as many are being harmed. With a lot of love and joy that I dedicate this work to all professional specialists, scientists and my parents, because without you, this diagnosis would not be possible.
Comparison of Techniques for Future Spaceborne GMTI

Future spaceborne radar systems will provide an increased flexibility for the radar operation compared to today's systems such as TerraSAR-X, Radarsat-2, or COSMO Skymed. This enables new strategies for the data acquisition. In this paper it is analyzed which flexibilities in the design of the high resolution wide swath synthetic aperture radar (HRWS-SAR) satellite are useful for the ground moving target indication (GMTI) capability of the system. In order to do so, first the possible flexibilities are introduced. Then a signal modeling including these flexibilitites is developed. Based on this, the use of these degrees of freedom for GMTI data acquisition is analyzed.
Azimuth Ambiguity Suppression for SAR via Variable PRF and Complex Image Deconvolution

The azimuth ambiguity phenomenon has widely existed in synthetic aperture radar (SAR). The false targets introduced by the ambiguity phenomenon may seriously affect the interpretation of SAR images. It is difficult for existing methods to suppress the azimuth ambiguity effectively at low oversampling rates. In this letter, we propose an approach of azimuth ambiguity suppression for SAR. The transmitted pulse sequence is changed to a nonuniform sampling pattern with multiple pulse repetition frequency (PRF) cycling. By taking the structural similarity of the ambiguity features as reference information, the Richardson–Lucy (RL) algorithm is utilized to suppress the ambiguity of SAR images through complex image deconvolution. The proposed method only requires simple changes to the transmitted pulse sequence and can be implemented without changing the hardware of existing SAR systems. It offers the capability to suppress the azimuth ambiguity of SAR at low oversampling rates. Experiments on real measured SAR data have verified the feasibility of the proposed method.
A Case of BRCA2-Pathogenic Variant Breast Cancer With Metachronous Endometrial Cancer and Pancreatic Cancer

Since the popularization of cancer screening and an improvement in treatment over the last two decades, multiple primary malignant neoplasms (MPMNs) have been increasingly reported. We report a patient who developed metachronous MPMNs in the breast, the endometrium, and the pancreas over a period of 13 years. A 42-year-old woman was first diagnosed with breast cancer and underwent breast-conserving surgery with adjuvant radiation therapy and endocrine therapy. Four years after breast surgery, she was diagnosed with endometrial cancer and underwent a laparoscopic modified radical hysterectomy with bilateral oophorectomy with pelvic lymph node dissection followed by adjuvant chemotherapy. However, there was peritoneal dissemination of endometrial cancer 1 year after surgery, which could be removed laparoscopically followed by adjuvant chemotherapy. Ten years after breast cancer surgery, pleural metastasis of breast cancer was diagnosed and treated by endocrine therapy. Thirteen years after breast cancer surgery, a pancreatic tumor with multiple liver masses emerged. It was difficult to diagnose whether primary or metastasis cancer by the results of the pathological analysis. Finally, we diagnosed primary pancreatic cancer with liver metastasis by clinical examination with the BRCA2-pathogenic variant. These tumors were well responded to chemotherapy and the patient survived during a follow-up period of 8 months. According to MPMNs, breast cancer patients should be followed-up carefully for the possibility of BRCA pathogenic variant and development of different primary malignant neoplasms.
Temporal Success Analyses in Music Collaboration Networks: Brazilian and Global Scenarios

Collaboration is a part of the music industry and has increased over recent decades; but little do we know about its effects on success and evolution. Our goal is to analyze how success has evolved over collaboration networks and compare its global scenario to a local, thriving one: the Brazilian music industry. Specifically, we build collaboration networks from data collected from Spotify's Global and Brazilian daily charts, analyze them and identify collaboration profiles in such networks. Analyses over their topological characteristics reveal collaboration patterns mapped into four different profiles: Standard, Niche, Ephemeral and Absent, where the two first have a higher level of success. Furthermore, we do deeper by evaluating the temporal evolution of such profiles through case studies: pop and k-pop globally, and pop and forró in Brazil. Overall, our findings emphasize the importance of collaboration profiles in assessing success, and show differences between the global and Brazilian scenarios.