Miracle-dz/UniFAR-FTUs huggingface dataset:
The association between monocyte to high-density lipoprotein cholesterol ratio and clinical prognosis of acute ischemic stroke after intravenous thrombolysis therapy

The monocyte-to-high-density lipoprotein cholesterol (HDL) ratio (MHR) is accepted as a novel marker for demonstrating inflammation. We investigated whether the monocyte-to-HDL ratio is related to the 90-day clinical prognosis of acute ischemic stroke (AIS) after intravenous thrombolysis (IVT). Patients with AIS treated with alteplase IVT were included consecutively, and clinical information and laboratory data were collected. The 90-day prognosis of all patients was determined with a clinical assessment using the modified Rankin Scale (mRS). The optimal cutoff values for patients were evaluated by the receiver operating characteristic (ROC) curve method. Then, a multivariate logistic regression model was used to evaluate the risk factors for poor prognosis of IVT in AIS. We retrospectively enrolled 192 patients who were diagnosed with AIS and received IVT between February 2020 and July 2022, with final follow-up on September 30, 2022. The patients in the poor prognosis group had significantly higher monocyte counts, lower HDL levels, and higher MHR values than the good prognosis group. The optimal cutoff value of the MHR for predicting the 3-month outcome of acute pontine infarction was 0.621. Multivariate logistic regression revealed that the MHR (OR = 4.626, 95% CI: 1.156–18.512, P = .030) was strongly associated with poor prognosis in AIS. The MHR is an independent risk factor for the clinical prognosis of AIS patients receiving IVT therapy and shows a certain predictive value.
Long‐term oscillations in rainfall extremes in a 268 year daily time series

We analyze long‐term fluctuations of rainfall extremes in 268 years of daily observations (Padova, Italy, 1725–2006), to our knowledge, the longest existing instrumental time series of its kind. We identify multidecadal oscillations in extremes estimated by fitting the GEV distribution, with approximate periodicities of about 17–21, 30–38, 49–68, 85–94, and 145–172 years. The amplitudes of these oscillations exceed the changes associated with the observed trend in intensity. This finding implies that even if climatic trends are absent or negligible, rainfall and its extremes exhibit an apparent nonstationarity if analyzed over time intervals shorter than the longest periodicity in the data (about 170 years for the case analyzed here). These results suggest that because long‐term periodicities may likely be present elsewhere, in the absence of observational time series with length comparable to such periodicities (possibly exceeding one century), past observations cannot be considered to be representative of future extremes. We also find that observed fluctuations in extreme events in Padova are linked to the North Atlantic Oscillation: increases in the NAO Index are on average associated with an intensification of daily extreme rainfall events. This link with the NAO global pattern is highly suggestive of implications of general relevance: long‐term fluctuations in rainfall extremes connected with large‐scale oscillating atmospheric patterns are likely to be widely present and undermine the very basic idea of using a single stationary distribution to infer future extremes from past observations.
Climate change impacts on the spatial extent of snow-cover in the Australian Alps

Changes in regional climate due to enhancement of the global greenhouse effect have the potential to affect the natural environment of the Australian Alps significantly as well as many mountain-based human activities. In particular, a major physical impact expected due to climate change is a reduction in natural snow cover as a consequence of higher temperatures. This would affect skiing activities and storage of water for irrigation among other impacts. This chapter presents new simulations of future snow cover in the Australian Alps based on the revised scenarios of GIG. Thus this chapter represents an update to Whetton et al (1996), taking into account revisions to projections of future climate change. In addition this chapter also briefly considers impacts of climate change on the alpine environment.
Muscle synergies analysis shows altered neural strategies in women with patellofemoral pain during walking

Several studies suggest that the central nervous system coordinates muscle activation by modulating neural commands directed to groups of muscles combined to form muscle synergies. Individuals with patellofemoral pain (PFP) move differently from asymptomatic individuals. Understanding the neural strategies involved in the execution of tasks such as walking can help comprehend how the movement is planned and better understand this clinical condition. The objective of this study was to compare muscle synergies between women with and without PFP during walking. Eleven women with PFP and thirteen asymptomatic women were assessed using three-dimensional kinematics and electromyography (EMG) while walking at self-selected speed. Kinematics of the trunk, pelvis and lower limbs were analyzed through the Movement Deviation Profile. Muscle synergies were extracted from the EMG signals of eight lower limb muscles collected throughout the whole gait cycle. Kinematic differences between the two groups (p<0.001, z-score = 3.06) were more evident during loading response, terminal stance, and pre-swing. PFP group presented a lower number of muscle synergies (p = 0.037), and greater variability accounted for (VAFtotal) when using 3 (p = 0.017), 4 (p = 0.004), and 5 (p = 0.012) synergies to reconstruct all EMG signals. The PFP group also presented higher VAFmuscle for rectus femoris (p = 0.048) and gastrocnemius medialis (p = 0.019) when considering 4 synergies. Our results suggest that women with PFP show lower motor complexity and deficit in muscle coordination to execute gait, indicating that gait in PFP is the result of different neural commands compared to asymptomatic women.
NUMERICAL SIMULATION OF THE INITIATION OF SUBDUCTION AT THE FRACTURE ZONE

In order to predict the future process of crustal and lithospheric movement at the gigantic fracture zone in the Northeastern Pacific, numerical simulation of contact between two kinds of viscous fluid of different density was performed. The results suggest that there occurs downgoing motion of the higher density fluid towards the lower density fluid and that formation of a trench will appear in several tens of million years from the standpoint of both bottom topography and lithospheric structure.
Viewing the morphology of the Mid-Atlantic Ridge from a new perspective

The nature of the volcanic and tectonic response of mid-ocean ridges to magmatic and rifting processes is a key component in understanding how new ocean crust is created. New high-resolution side-scan sonar images of the axis of the slow-spreading Mid-Atlantic Ridge (MAR) show volcanic constructs and faults and fissures that are similar in size and shape to those observed at well-studied subaerial rift zones such as Hawaii and Iceland. The new information provided by these high resolution side-scan sonar images, combined with swath bathymetric coverage, is now allowing us to apply the terrestrial analogs to the MAR to understand dike emplacement, shallow transport of magma, eruption mechanisms, tectonic strain, and crustal evolution.
Comparing reintroduction strategies for the endangered San Francisco gartersnake (Thamnophis sirtalis tetrataenia) using demographic models

For endangered species persisting in a few populations, reintroductions to unoccupied habitat are a popular conservation action to increase viability in the long term. Identifying the reintroduction strategy that is most likely to result in viable founder and donor populations is essential to optimally use resources available for conservation. The San Francisco gartersnake (Thamnophis sirtalis tetrataenia) is an endangered sub-species that persists in a small number of populations in a highly urbanized region of California. Most of the extant populations of San Francisco gartersnakes have low adult abundance and effective population size, heightening the need for establishment of more populations for insurance against the risk of extinction. We used simulations from demographic models to project the probability of quasi-extinction for reintroduced populations of San Francisco gartersnakes based on the release of neonate, juvenile, adult, or mixed-age propagules. Our simulation results indicated that the release of head-started juveniles resulted in the greatest viability of reintroduced populations, and that releases would need to continue for at least 15 years to ensure a low probability of quasi-extinction. Releasing captive-bred juvenile snakes would also have less effect on the viability of the donor population, compared to strategies that require more adult snakes to be removed from the donor population for translocation. Our models focus on snake demography, but the genetic makeup of donor, captive, and reintroduced populations will also be a major concern for any proposed reintroduction plan. This study demonstrates how modeling can be used to inform reintroduction strategies for highly imperiled species.
Predicting use of a gait-stabilizing device using a Wii Balance Board

Gait-stabilizing devices (GSDs) are effective at preventing falls, but people are often reluctant to use them until after experiencing a fall. Inexpensive, convenient, and effective methods for predicting which patients need GSDs could help improve adoption. The purpose of this study was to determine if a Wii Balance Board (WBB) can be used to determine whether or not patients use a GSD. We prospectively recruited participants ages 70–100, some who used GSDs and some who did not. Participants first answered questions from the Modified Vulnerable Elders Survey, and then completed a grip-strength test using a handgrip dynamometer. Finally, they were asked to complete a series of four 30-second balance tests on a WBB in random order: (1) eyes open, feet apart; (2) eyes open, feet together; (3) eyes closed, feet apart; and (4) eyes closed, feet together. The four-test series was repeated a second time in the same random order. The resulting data, represented as 25 features extracted from the questionnaires and the grip test, and data from the eight balance tests, were used to predict a subject’s GSD use using generalized functional linear models based on the Bernoulli distribution. 268 participants were consented; 62 were missing data elements and were removed from analysis; 109 were not GSD users and 97 were GSD users. The use of velocity and acceleration information from the WBB improved upon predictions based solely on grip strength, demographic, and survey variables. The WBB is a convenient, inexpensive, and easy-to-use device that can be used to recommend whether or not patients should be using a GSD.
Assessment of post-traumatic stress disorder and health-related quality of life among patients recovered from mild-to-moderate COVID-19 and their close contacts: A cross-sectional study

The pandemic of COVID-19 is a traumatic event with distressing implications for mental health and several aspects of life. This study aimed to assess Post-traumatic Stress Disorder (PTSD) and Health-Related Quality of Life (HRQoL) among patients who experienced mild-to-moderate COVID-19 and their household contacts. This cross-sectional descriptive study was conducted between May 2020 and November 2020, in Ismailia and Suez governorates. A convenient sampling method was used. The sample size was calculated according to the prevalence of PTSD in COVID-19 patients to be 200 adult participants from both sexes, 100 patients with history of recent COVID-19 infection (up to 2 months after recovery) and their close family. COVID-19 was confirmed by a nasal swab sample tested by PCR in addition to suggestive symptoms and/or positive computed tomography lung findings. Data was collected by using the Arabic version of the Post-Traumatic Stress disorder checklist 5 (PCL5-PTSD) and the Arabic version of Health-Related Quality of Life (HRQoL). The questionnaire was collected through interviews at the Endemic and Infectious diseases and Family medicine outpatient clinics. Of the 200 studied participants, evidence of PTSD was found in 112 (56%) participants; all COVID-19 cases and 12 of their close-contact relatives. Impaired HRQoL was evident in 107 (53.5%) participants; all the COVID-19 cases and 7 contacts. The mean values total scores of the PTSD and HRQoL and its domains were significantly higher among cases compared to their contacts. The most frequently impaired domain was social (55%), psychological (54.5%), impairment (53.5%) followed by physical (48.5%) and the least was health perception (33.5%). The mean values of PTSD, HRQoL and their domains were significantly higher among participants who recalled respiratory symptoms and who had comorbid illness. The odds ratio of PTSD and HRQoL was 0.27 (95% CI: 0.2–0.36) and 0.3 (95% CI: 0.23–0.39) in participants who had more than a case of COVID-19 within their families. All the studied COVID-19 participants showed PTSD and impaired HRQoL, compared to 12% and 7% of their contacts, respectively. Past COVID-19 was associated with impairment of all domains of HRQoL and the most affected were the physical, psychological and impairment domains.
How do US corporations communicate interculturally with their Chinese stakeholders: Analysis of GM Company’s social media posts from the cultural value perspective

Social Media is an important means of communication with audiences around the world. The purpose of this study was to explore whether GM—a famous US auto company adapts its US Cultural values to suit the prevalent cultural values of its Chinese stakeholders on Chinese social media. Content analysis was used to evaluate the cultural content of GM Company’s posts on Weibo and Twitter. Although influenced by the special features of the car industry, there is still enough evidence that the communication style of the US auto Company makes cultural adaption on Chinese social media, reflecting more Chinese prevalent cultural values.
A microbial functional group‐based module for simulating methane production and consumption: Application to an incubated permafrost soil

Accurately estimating methane (CH4) flux in terrestrial ecosystems is critically important for investigating and predicting biogeochemistry‐climate feedbacks. Improved simulations of CH4 flux require explicit representations of the microbial processes that account for CH4 dynamics. A microbial functional group‐based module was developed, building on the decomposition subroutine of the Community Land Model 4.5. This module considers four key mechanisms for CH4 production and consumption: methanogenesis from acetate or from single‐carbon compounds and CH4 oxidation using molecular oxygen or other inorganic electron acceptors. Four microbial functional groups perform these processes: acetoclastic methanogens, hydrogenotrophic methanogens, aerobic methanotrophs, and anaerobic methanotrophs. This module was used to simulate dynamics of carbon dioxide (CO2) and CH4 concentrations from an incubation experiment with permafrost soils. The results show that the model captures the dynamics of CO2 and CH4 concentrations in microcosms with top soils, mineral layer soils, and permafrost soils under natural and saturated moisture conditions and three temperature conditions of −2°C, 3°C, and 5°C (R2 > 0.67; P < 0.001). The biases for modeled results are less than 30% across the soil samples and moisture and temperature conditions. Sensitivity analysis confirmed the importance of acetic acid's direct contribution as substrate and indirect effects through pH feedback on CO2 and CH4 production and consumption. This study suggests that representing the microbial mechanisms is critical for modeling CH4 production and consumption; it is urgent to incorporate microbial mechanisms into Earth system models for better predicting trace gas dynamics and the behavior of the climate system.
Shared genetic links between bladder cancer and obesity-related traits: A conjunctional false discovery rate study

Bladder cancer (BCa) is a common cancer worldwide and is often linked with obesity-related comorbidities, but little is known about the underlying genetic mechanisms. To investigate these mechanisms, we used various quantitative tools, including conditional quantile-quantile (Q-Q) plots, conditional false discovery rate (cFDR), and conjunctional conditional false discovery rate (ccFDR), to explore the pleiotropic enrichment of risk loci between BCa and obesity-related traits. We also performed an expression quantitative trait locus (eQTL) analysis to assess the relationship between shared risk loci and gene expression. Finally, we conducted functional annotation using Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene ontology (GO) analysis. Our findings indicated that there was successive enrichment for a range of obesity-related traits, including body fat percentage, body mass index, fasting insulin, type 2 diabetes mellitus, fasting glucose, high-density lipoprotein cholesterol, total triglycerides, and waist-to-hip ratio. Using the tools mentioned above, we identified 18 significant SNPs and 18 closely related genes (cFDR<0.01) under the condition of 8 obesity-related traits. The SNPs included rs143004880, rs73301337, rs10798572, rs11594929, rs17019138, rs2877, rs149795948, rs142509736, rs12727575, rs1571277, rs12131828, rs635634, rs76895963, rs118081211, rs7044247, rs138895564, rs4135275, and rs148023060. Additionally, we identified 15 novel loci using ccFDR, including rs143004880, rs73301337, rs10798572, rs11594929, rs17019138, rs2877, rs142509736, rs1571277, rs635634, rs76895963, rs12131828, rs118081211, rs7044247, rs138895564, and rs4135275. Of the 2 significant loci that modify gene expression, rs12131828 and rs635634 were identified. The functional annotation indicated that the conditional risk genes mainly participated in the regulation of gene silencing. Our study provided evidence of pleiotropic enrichment between BCa and 8 obesity-related traits, and we identified potential genetic mechanisms underlying this relationship. These findings may help in developing targeted clinical treatments for BCa.
SEKTÖREL AÇIDAN ENERJİNİN ARTAN ÖNEMİ: KONYA İLİ İÇİN BİR DOĞALGAZ TALEP TAHMİNİ DENEMESİ

Turkiye’de 1980’li yillardan itibaren iktisadi anlamda yapisal bir degisim/donusum surecine girilmistir. Bu surecte enerji kullanimi acisindan dogalgaz temel girdi olarak kabul edilmistir. Gunumuzde bircok sektorde dogalgazini tuketimi surekli olarak artmaktadir. Ekonomik gelisme acisindan enerjinin onemi herkes tarafindan kabul edildigine gore, dogalgaz talebi konusunda gelecege yonelik ongorulurde bulunulmasi, istikrarli bir ekonomik gelisme acisindan onem arz etmektedir. Bu calismada bolgesel acidan onemli bir gelisme potansiyeline sahip olan Konya’da, gelecek donemlerde enerjinin guvenilir ve saglikli bir sekilde tedarik edilebilmesi acisindan dogalgaz talebine iliskin ongorulerde bulunulmasi amaclanmistir. Bu amac dogrultusunda yapilan analizlerde hanehalki dogal gaz talebinin aylar itibari ile dalgalanmalar ve mevsimsellik gosterecegi beklenmektedir. Sanayi sektoru icin yapilan analizlerde ise tuketimin yillar itibari ile bir artis trendine girecegi ongorulmektedir.
Late-Holocene Flood History, Flood-Frequency, and Paleoclimate Analysis of the Central Black Hills, South Dakota

Stratigraphic records in four basins in the central Black Hills in combination with hydraulic calculations show that all basins have experienced multiple large floods in the last 2,000 years with flow rates substantially larger than those gaged historically. Floodfrequency analyses for the study reaches account for 29 paleofloods inferred from interpretation of stratigraphic records locally extending back 1,000 to almost 2,000 years. The addition of paleoflood data to the gaged and historical data significantly reduced uncertainties related to flood-frequency. For all study reaches the 95-percent confidence intervals about the low-probability quantile estimates (100-, 200-, and 500-year recurrence-intervals) were reduced by at least 78 percent relative to those for the gaged records only. In some cases, 95-percent uncertainty intervals were reduced by 99 percent
Use of Peroral Pancreatoscopy in the Diagnosis of Elusive Intraductal Papillary Mucinous Neoplasm With High-Grade Dysplasia

ABSTRACT Intraductal papillary mucinous neoplasm (IPMN) is a premalignant lesion of the pancreas that can occasionally manifest as recurrent acute pancreatitis. In this report, we discuss a unique case of a 49-year-old woman who presented with recurrent acute pancreatitis of an unknown cause for several years. Workup using peroral pancreatoscopy eventually showed main-duct IPMN with high-grade dysplasia as the obscure cause of recurrent acute pancreatitis. This case report highlights the clinical course of main-duct IPMN and the evolving role of peroral pancreatoscopy in patients with recurrent acute pancreatitis.
Triple isotope composition of oxygen in atmospheric water vapor

Recently, an excess of 17O (17O‐excess) has been demonstrated in meteoric water and ice cores. Based on theory and experiments, it has been suggested that this excess originates from evaporation of ocean water into under‐saturated air. However, there has never been direct demonstration of this excess in marine vapor. Here, we present results of the first measurements of δ17O and δ18O in vapor samples collected over the South Indian and the Southern Oceans. Our data show the existence of 17O‐excess in marine vapor and also clear negative correlation between 17O‐excess and relative humidity. Thus, 17O‐excess is useful for constraining oceanic humidity in hydrological and climatic models. Using the obtained values of 17O‐excess, we estimated the fractionation factor between H218O and H216O for diffusion in air above the ocean (18αdiff). The new estimation of 18αdiff (1.008) is larger than the widely accepted value in hydrological studies.
Current complementary and alternative therapy forgastroesophageal reflux disease

Abstract Gastroesophageal reflux disease (GERD) is a widely prevalent gastrointestinal disorder, affecting ∼13.3% of the global population. There are shortages and limitations of current GERD treatment modalities, and complementary and alternative therapy (CAT) is a promising option to fill in the gap. Dietary and lifestyle modifications might play an important and complementary role in alleviating GERD symptoms. Traditional Chinese medicine and brain–gut behavior therapy, particularly transcutaneous electrical acustimulation and diaphragmatic breathing therapy were shown to be useful adjuncts or alternatives in treating GERD. CAT may help to relieve GERD symptoms, minimize medication dosage, and slow the demand for surgery. The aim of this review was to summarize the existing evidence of some common CATs in treating symptomatic GERD, including dietary modification, lifestyle change, traditional Chinese medicine, and brain–gut behavior therapy.