Miracle-dz/UniFAR-FTUs huggingface dataset:
The immunolocalization of HIF‐2α, GLUT1 and CAIX in porcine oviduct during the estrous cycle

Oxygen (O2) rates in the oviduct are essential to human and animal reproduction. These rates are regulated by the activity of hypoxia markers such as the hypoxia‐inducible factors (HIFs), the glucose transporters (GLUT), and the carbonic anhydrase (CA). In the porcine model, scarce studies have been reported regarding these markers and their effects in reproduction are unknown. The objective was to characterize the immunolocalization of HIF‐2α, GLUT1, and CAIX in porcine oviducts throughout the estrous cycle. Oviducts (ampulla and isthmus) of adult sows (n = 45) were collected for histological and immunohistochemical analysis with HIF‐2α, GLUT1, and CAIX markers. The percentage of immunopositive area was quantified, and the differences among phases of the estrous cycle were analyzed (folicular, early luteal, and late luteal). The three markers showed epithelial presence mainly. Significantly lower expression of HIF‐2α was found in the luteal phases, especially in the isthmus. GLUT1 expression did not change throughout the estrous cycle, but differences were found between the ampulla and isthmus. CAIX expression showed the highest, with a significant downward trend throughout estrous cycle. The ubiquitous expression of hypoxia markers shows the porcine oviduct physiology in relation to O2. The differential expression of HIF‐2α, GLUT1, and CAIX in different subcompartments of the oviduct throughout the estrous cycle contributes to improve the knowledge of the cell physiology of the oviduct, which can be useful in fertilization studies.
A Process for Strategic Positioning in IT Management: 9. JAIS Theory Development Workshop

The management of IT in a corporate context has evolved from technology provider to service partner of the business. To help understand the resulting changes in IT management, this paper presents a grounded theory explaining the process and the effects of strategically positioning an IT department as part of strategy development in IT management. We use a set of three case studies for building our suggested theory for explanation. In uncovering the theory and its constituents from our empirical material, we follow a grounded theory approach. Our research introduces social dynamics in the group of IT executives participating in strategic positioning as an important and novel determinant of planning and im-plementation success. Introducing a detailed process description, our process theory highlights how strategic positioning is currently approached and what effects unfold as a result. Our research helps to better understand how the contemporary role of IT in business has impacted strategizing and managing in the IT context. It shows that IT manage-ment becomes more and more emancipated and that research beyond the content of strategy can help to better understand the success of IT management. This, in turn, can help practitioners to improve their management approaches to better align their IT departments and increase their value contribution.
How Can Nutrition Research Better Reflect the Relationship Between Wasting and Stunting in Children? Learnings from the Wasting and Stunting Project

ABSTRACT Childhood wasting and stunting affect large numbers of children globally. Both are important risk factors for illness and death yet, despite the fact that these conditions can share common risk factors and are often seen in the same child, they are commonly portrayed as relatively distinct manifestations of undernutrition. In 2014, the Wasting and Stunting project was launched by the Emergency Nutrition Network. Its aim was to better understand the complex relationship and associations between wasting and stunting and examine whether current separations that were apparent in approaches to policy, financing, and programs were justified or useful. Based on the project's work, this article aims to bring a wasting and stunting lens to how research is designed and financed in order for the nutrition community to better understand, prevent, and treat child undernutrition. Discussion of lessons learnt focuses on the synergy and temporal relationships between children's weight loss and linear growth faltering, the proximal and distal factors that drive diverse forms of undernutrition, and identifying and targeting people most at risk. Supporting progress in all these areas requires research collaborations across interest groups that highlight the value of research that moves beyond a focus on single forms of undernutrition, and ensures that there is equal attention given to wasting as to other forms of malnutrition, wherever it is present.
Effects of plant diversity and abiotic factors on the multifunctionality of an arid desert ecosystem

Many studies suggest that species diversity and abiotic factors promote ecosystem multifunctionality. However, whether ecosystem multifunctionality is impacted by phylogenetic diversity remains controversial. The present study tested this in an arid desert ecosystem in Ebinur Lake Basin using soil C:N ratio, soil pH, and soil salinity as abiotic factors, and species diversity and phylogenetic diversity as indicators of plant diversity. The effects of plant diversity and abiotic factors on single ecosystem functions (nutrient cycling, carbon stocks, water regulation, and wood production) and ecosystem multifunctionality were studied. We used structural equation modeling to assess the relationships among different functional groups and factors. The results showed that: (1) abiotic factors, particularly pH and C:N ratio in soil, had the strongest positive impact on multifunctionality (P < 0.001). The phylogenetic diversity and species diversity showed inconsistent changes, and their contribution to multifunctionality were not outstanding. (2) Abiotic factors were closely related to different ecosystem functions. Soil C:N had a significant positive effect on carbon stocks (P < 0.001), with an effect index of 0.89. Soil pH significantly enhanced nutrient cycling and water regulation. The role of plant diversity varied with the combination of different ecosystem functions. Phylogenetic diversity and species diversity influenced wood production, but showed opposite functions. (3) The importance of four single-ecosystem functions in an arid region was ranked as follows: carbon stocks > water regulation > nutrient cycling > wood production, emphasizing the importance of carbon elements in these ecosystems. These results improve our understanding of the drivers of multifunctionality in arid ecosystems, facilitating the elucidation of the influence of abiotic factors and phylogenetic diversity.
The Moderating Role of Interorganizational Information Systems in Maximizing the Operational Performance of Dyadic Business Relationships: a Conceptual Model

—The objective of this study is twofold: first, to examine how the structure of a buyer-supplier relationship impacts the operational performance of the supplier involved in the dyadic relationship and second, to test the moderating impact of interorganizational information systems (IOS) usage (assessed through the dimensions of volume, diversity and depth) on the relationship between the structure of a buyer-supplier relationship and the operational performance of the supplier involved in the dyadic relationship. To do so, the marketing and IOS literatures are reviewed to propose a model and seven research hypotheses. Then, the methodology we intend to use to test our conceptual framework is explained. Lastly, the anticipated theoretical contributions and practical implications of the study are discussed.
RUNNING HEAD: ANXIETY SENSITIVITY AND CHRONIC ILLNESS Investigating the Relationship Between Anxiety Sensitivity and Chronic Illness: A Replication and Extension By:

In the United States, chronic illness and anxiety disorders are two of the largest burdens on the healthcare system. Almost half the population of the United States has been diagnosed with a chronic illness, and anxiety disorders are the most commonly diagnosed mental illness. The comorbidity between chronic illness and anxiety is fairly common and well-studied. Previous research has shown connections between anxiety and hypertension, heart disease, high cholesterol, and arthritis. One factor that may maintain the comorbidity between anxiety and chronic illness is anxiety sensitivity (AS) and its three subfactors: physical, social, and cognitive. The goal of this study was to investigate the relationship between the subfactors of AS and four chronic illnesses. In addition, the study looked at the role of anxiety sensitivity in those with multiple chronic illnesses and decreased quality of life. Data were gathered from a community sample of 1,002 community individuals. Significant relationships were found between hypertension and physical AS, and high cholesterol and cognitive AS. All subfactors of AS were related to having multiple chronic illnesses, and chronic illness was indicative of decreased quality of life. ANXIETY SENSITIVITY AND CHRONIC ILLNESS 3 Investigating the Relationship Between Anxiety Sensitivity and Chronic Illness: A Replication and Extension
Boosting SEO Tactics: Using SEO Tools

— Search engine optimization – commonly abbreviated to SEO – is the process wherebyin which a web site, or more specifically a web page or document, is constructed or modified amended in such a way as to improve its placement in the search engine results pages or SERPs. The site content analyzer3 tool is the perfect tool which is used to measure the content quality. The Site content analyzer3 tool provide a number of useful parameters named as: keyword density, keyword weight, keyword distribution; discover the most relevant keyword and key phrases, find out the quality of in-site links, overview the whole site-wide picture and many more. The Total Backlink Analyzer tool is an online tool used for finding the backlinks of Websites.This tool generates the total no. of important links connected to the website.
PPA_A_319193 1707..1715

1Department of Preventive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, 31441, Eastern Province, Saudi Arabia; 2Department of Restorative Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, 31441, Eastern Province, Saudi Arabia; 3College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, 31441, Eastern Province, Saudi Arabia Purpose: Dental fear is associated with the avoidance of dental visits and negative oral health outcomes. It is important to assess distribution of dental fear and preference for emergency dental treatment among adult population during COVID-19. Therefore, the purpose of this study was to evaluate dental fear and emergency dental treatment among adults in COVID-19 quarantine centers in Greater Dammam, Saudi Arabia. Materials and Methods: Male and female adults (N=606) in quarantine centers for COVID19 participated in this cross-sectional study (June–July 2020). Dental Fear Survey was used to collect data on dental fear. The participants also provided their responses about emergency dental treatment/dental attendance patterns in addition to demographic information. Results: The mean DFS score of the sample was 39.08 ± 19.47, and 23.1% of the participants were a little fearful and 22.6% were highly fearful. About 36.8% reported that they would prefer to visit a dental office in case of dental emergency mostly for dental pain and fractured tooth during the COVID-19 pandemic. Only 10.4% of the participants reported visiting a dentist in less than 3 months, 35.8% in less than 6 months, 52.5% between 6 and 12 months and more, and 1.3% never visited the dentist. DFS scores significantly differed among participants who visited the dentist in less than 3 months (31.86 ± 14.57), less than 6 months (37.70 ± 18.57), between 6 and 12 months and more (40.78 ± 20.23), and never visited the dentist (65.75 ± 14.74) (P < 0.001). The timing of last dental visit (P < 0.001), female gender (P 0.039), and dental pain (P < 0.001) were the significant predictors of dental fear. Conclusion: Dental fear was common among adults with a predilection for the female gender. Increased dental fear was significantly related to dental pain and reduced dental attendance. Only one-third of adults were willing to perform emergency dental visits.
Localização e navegacão de um robô móvel omnidirecional: caso de estudo da competição robot@factory

—The Robot@Factory competition, was recently included in Robotica, the main Robotics Portuguese Competition. This robot competition takes place in an emulated factory plant, where Automatic Guided Vehicles (AGVs) must cooperate to perform tasks. To accomplish their goals the AGVs must deal with localization, navigation, scheduling and cooperation problems, that must be solved autonomously. The presented robot competition can play an important role in education due to the inherent multi-disciplinary concepts that are involved, motivating students to technological areas. It also plays an important role in research and development, because it is expected that the outcomes that will emerge here, will later be transfered to other application areas, such as service robots and manufacturing. By presenting a scaled down factory shop ﬂoor, this competition creates a benchmark that can be used to compare different approaches to the problems that arise on this kind of environments. Also, the ability, in some restricted areas, to alter the environment, can promote the test and evaluation of different localization mechanisms, something that is usually, more restricted in other competitions, opening this area to be explored and benchmarked. In this paper it is discussed one of the possible approaches, that can be applied to the robot competition, serving as reference to the actual and new potential participating teams.
KINETOSTATIC ANALYSIS OF KNEE JOINT USING MBS SIMULATION

The paper presents the kinetostatic analysis of the right and left knee joints using a multibody system that replicates the human body lower limbs. The model is developed in MSC Adams and it composed of 7 kinematic elements (pelvis, right and left femur, right and left tibia and right and left foot) interconnected through 6 spherical joints constrained to 1 degree of freedom each (DOF). To simulate the MBS system we have developed laws of motion for 6 major joints composing the human lower limbs structure (right and left hip, right and left knee and right and left ankle). The laws of motion were determined based on kinematic data generated by a depth camera. Thus, determining the MBS model kinematics we were able to conduct the kinetostatic analysis using the inverse dynamic analysis principles. The MBS system was simulated during bipedal cycle walk of 2 steps in 3 loading cases: normal weight (43.38 Kg), with an additional weight of 34.46% equivalent of 146.599 N and with an additional weight of 64.93% equivalent of 276.233 N. The kinetostatic analysis has provided the ground reaction forces variation with respect to time for left and right knee joints (LKJ, RKJ) in the 3 loading cases.
The Architecture of the Nuclear Pore Complex

Nucleocytoplasmic transport, the regulated trafficking of macromolecules in and out of the nucleus, occurs primarily through nuclear pore complexes (NPCs). NPCs are massive macromolecular machines embedded in the nuclear envelope which generate ~40 nanometer transport channels to facilitate transport. Because of its size and complexity (~1000 subunits, ~120 MDa), the structure of the NPC has remained poorly understood. This thesis presents a bottom-up approach to understanding the structure and function of the NPC through reconstitution of the proteins and structural and biochemical studies. The first three chapters present work towards determining the composite structure of the symmetric core of the NPC. X-ray crystal structures are described for many of the components of the symmetric core. This includes a heterohexameric coat nucleoporin complex containing Nup120, Nup85, Nup145C, Sec13, Seh1, and Nup84, revealing how these proteins assemble into one of the main subcomplexes in the NPC. Reconstitution of the symmetric core components and analysis of the protein-protein interaction between the components provides a detailed biochemical map for the protein interaction network in the NPC. X-ray crystal structures of overlapping fragments facilitate the generation of accurate atomic model for full-length proteins. An iterative, sequential docking approach is developed to dock these models into a cryoelectron tomographic reconstruction of the human NPC, yielding a composite model for the structure of the symmetric core of the NPC. In the next two chapters, this analysis is extended to the cytoplasmic-specific decorations of the NPC. The structure of the C-terminal domain of Nup358 is reported and its catalytic activity is described. Lastly, reconstitution of human DDX19 activation by the NPC reveals mechanistic insight into how the NPC directly regulates the last step of mRNA export.
Embedded Personal Physicalizations

— With the emergence of quantiﬁed-self, smart devices, Internet of Things and ubiquitous robotics, we envision new opportunities to create dynamic embedded physicalizations. In particular, we see new challenges arising in the context of personal and casual physicalizations at home. In this paper, we discuss the research directions and potential beneﬁts of dynamic embedded physicalizations in the residential context, or Embedded Personal Physicalizations .
Heritability of Carotid Artery Atherosclerotic Lesions

Background and Purpose—Ultrasound examination of the carotid arteries yields several quantitative measures that may serve as intermediate phenotypes in genetic studies. This study was undertaken to compare the heritabilities of 3 ultrasound measures: intima-media thickness (IMT), plaque score, and maximal stenosis. Methods—We studied 565 individuals from 154 families ascertained by an affected parent with carotid artery atherosclerosis. IMT, plaque score, and maximal stenosis of the carotid arteries were examined by B-mode ultrasound and analyzed quantitatively. Heritability estimates were obtained by variance component analysis as implemented in the program SOLAR (sequential oligogenic linkage analysis routines). Covariates were age, sex, weight, height, body mass index (BMI), arterial hypertension, diabetes mellitus, amount of nicotine consumed, and plasma levels of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, LDL/HDL ratio, lipoprotein(a) [Lp(a)], triglycerides, factor VIII, factor XIII, fibrinogen, and von Willebrand factor (vWF). Results—After accounting for the covariables age, sex, hypertension, diabetes mellitus, and Lp(a), heritability of IMT was estimated as h 0.61 0.17 (P 0.001). Variation of plaque score was influenced by age, sex, hypertension, diabetes mellitus, hypercholesterolemia, amount of nicotine consumed, factor VIII, and vWF. When these were considered, no significant heritability could be detected. Heritability of stenosis was estimated as h 0.47 0.07 (P 0.006), with age, sex, BMI, hypertension, diabetes mellitus, amount of nicotine consumed, and LDL/HDL ratio as covariates. Conclusions—Among the 3 ultrasound measures studied, IMT had the highest heritability. IMT was strongly influenced by genetic determinants other than those influencing known risk factors. This makes IMT a promising candidate for use as an intermediate phenotype in genetic studies aiming to identify novel genes for atherosclerosis. (Stroke. 2005;36:5-8.)
Emerging therapeutic paradigms to target the dysregulated JAK/ STAT pathways in hematological malignancies

Over the past decade, there has been increasing biochemical evidence that the Janus kinase (JAK)signal transducer and activator of transcription (STAT) pathway is aberrantly activated in malignant cells from patients with a wide spectrum of cancers of the blood and immune systems. The emerging availability of small molecule inhibitors of JAK kinases and other signaling molecules in the JAK-STAT pathway has allowed preclinical studies validating an important role of this pathway in the pathogenesis of many hematologic malignancies, and provided motivation for new strategies for treatment of these diseases. Here, a roundtable panel of experts reviews the current preclinical and clinical landscape of the JAK-STAT pathway in acute lymphoid and myeloid leukemias, lymphomas and myeloma, and chronic myeloid neoplasms. Corresponding author: Richard A. Van Etten, MD PhD, Chao Family Comprehensive Cancer Center, University of California, Irvine, 839 Medical Sciences Court, Sprague Hall, Room 124, Irvine, CA 92697-4047, vanetten@uci.edu, Tel (949) 824-2655, Fax (949) 824-4023. Authorship contributions T.I. M. , R.A. V. and W.H. W. designed the outline strategy. T.I. M. wrote the preliminary version of the paper. All authors participated in writing significant sections of the paper. Conflict of interest Disclosures O. Abdel-Wahab: No conflicts of interest J-J. Kiladjian: Advisory boards: Novartis, Sanofi, Shire, AOP Orphan; Research grants: Celgene, Novartis. S. Kumar: No conflicts of interest T. Mughal: Speakers’ bureau: Bristol-Myers Squibb; Consultancy: Incyte and Novartis S. Rosen: No conflicts of interest G. Saaulius: No conflicts of interest R. Van Etten: Consultancy: Bristol-Myers Squibb, TEVA Pharmaceuticals; Research support: TEVA Pharmaceuticals. A. Wiestner: No conflicts of interest W. Wilson: No conflicts of interest NIH Public Access Author Manuscript Leuk Lymphoma. Author manuscript; available in PMC 2015 September 01. Published in final edited form as: Leuk Lymphoma. 2014 September ; 55(9): 1968–1979. doi:10.3109/10428194.2013. 863307. N IH -P A A uhor M anscript N IH -P A A uhor M anscript N IH -P A A uhor M anscript
COPD_A_295321 1109..1118

1Nepal Health Research Council (NHRC), Kathmandu, Nepal; 2Department of Community Medicine, Maharajgunj Medical Campus, Kathmandu, Nepal; 3Institute of Occupational, Social and Environmental Medicine, Goethe University, Frankfurt am Main, Germany; 4Monitoring Evaluation and Operational Research (MEOR) Project, Abt Associates, Kathmandu, Nepal; 5KIST Medical College, Lalitpur, Nepal; 6Public Health Foundation of India, Bangalore, India
Comparing university education in open and focused majors: A look to the future

Article history: Received 4 September 2021 Received in revised form 8 December 2021 Accepted 26 December 2021 This study aims to redirect the human resources of university graduates towards the actual needs required of society. The huge increase in the number of graduates in the Arab world is not matched by economic growth and therefore organized labor markets that can harness the skills of graduates and invest in developing the new and future required skills to meet the challenges of the labor market. This study presents a broad comparison between the narrow and general concepts adopted in education. The study aims to provide an analysis of what should be the future direction of higher education in countries and how this can be applied to education systems in Arab countries such as Saudi Arabia. Finally, it makes evidencebased recommendations to support such strategic choices, and the study concludes that a broad system that does not integrate with market needs and operates away from serious partnership with stakeholders and employer groups will certainly fail to meet national needs and national aspirations, as the data analysis revealed. University students are gathering in majors to saturate the labor market with graduates with low potential to compete in the job market, and this has led to the recommendation to take serious steps that would stimulate efficiency and responsiveness to the system. New programs and curricula that reflect market demand Shifting resources towards such a system will benefit universities as they can focus on meeting skills needs and employers who can hire skilled employees through active participation in building skill sets.