Miracle-dz/UniFAR-FTUs huggingface dataset:
A Blockchain-Based Decentralized Public Key Infrastructure for Information-Centric Networks

How to achieve secure content distribution and accountability in information-centric networking (ICN) is a crucial problem. Subscribers need to verify whether the data came from a reliable source, rather than from a spoofing adversary. Public key cryptography was introduced to achieve a method of authentication that binds the data packet to its owner. In existing prototypes, PKIs, identity-based signatures (IBSs) and recommendation networks are the common schemes used to ensure the authenticity and availability of public keys. However, CA-based PKIs and KGC-based IBSs have been proven to be weak when it comes to resisting security attacks, with recommendation networks being too complex to deploy. In this respect, we designed a novel distributed authentication model as a secure scheme to support public key cryptography. Our model establishes a decentralized public key infrastructure by combining the smart contracts of blockchain and optimized zero-knowledge proof-verifiable presentations by utilizing the DID project, which realizes the management of public key certificates through blockchain and ensures the authenticity and availability of public keys in decentralized infrastructure. Our scheme fundamentally solves the issues of security and feasibility in existing schemes and provides a more scalable solution with respect to authenticating data sources. An experiment demonstrated that our proposal is 20% faster than the original zero knowledge proof scheme in registration.
Subduction, Underplating, and Return Flow Recorded in the Cycladic Blueschist Unit Exposed on Syros, Greece

Exhumed high‐pressure/low‐temperature (HP/LT) metamorphic rocks provide insights into deep (∼20–70 km) subduction interface dynamics. On Syros Island (Cyclades, Greece), the Cycladic Blueschist Unit preserves blueschist‐to‐eclogite facies oceanic‐ and continental‐affinity rocks that record the structural and thermal evolution linked to Eocene subduction. Despite decades of research, the metamorphic and deformation history (P‐T‐D) and timing of subduction and exhumation are matters of ongoing discussion. We suggest that Syros comprises three coherent tectonic slices and that each slice underwent subduction, underplating, and syn‐subduction return flow along similar P‐T trajectories, but at progressively younger times. Subduction and exhumation are distinguished by lineations and ductile fold axis orientations, and are kinematically consistent with previous studies that document top‐to‐the‐S‐SW shear (prograde‐to‐peak subduction), top‐to‐the‐NE shear (blueschist facies exhumation), and then E‐W coaxial stretching (greenschist facies exhumation). Amphibole zonations record cooling during decompression, indicating return flow above a cold slab. Multi‐mineral Rb‐Sr isochrons and compiled metamorphic geochronology show that the three slices record distinct stages of peak subduction (53–52, ∼50, and 45 Ma) that young with structural depth. Retrograde blueschist and greenschist facies fabrics span ∼50–40 and ∼43–20 Ma, respectively, and also young with structural depth. Synthesized data sets support a revised tectonic framework for Syros, involving subduction of structurally distinct coherent slices and simultaneous return flow of previously accreted tectonic slices in the subduction channel shear zone. Distributed, ductile, dominantly coaxial return flow in an Eocene‐Oligocene subduction channel proceeded at rates of ∼1.5–5 mm/yr and accommodated ∼80% of the total exhumation of this HP/LT complex.
DESIGN AND DEVELOPMENT OF ROPE CLIMBING DEVICE FOR MULTI STOREY BUILDINGS

Hoisting devices are a special category of devices used for working on tall buildings and in hazardous locations where it is difficult for human beings to operate. Rope climbing devices have been developed for various functions and wide ranging tasks for construction and material handling in not too tall buildings. The ease of operating rope climbing devices is high as compared to complicated and heavy hoisting systems normally used for tall buildings. Besides, such devices do not cost much. In this paper, the focus is on developing a low cost and reliable vertical climbing that is simple in operation and is useful for construction of buildings of about 5-6 stories. The drive is a simple roller squeeze mechanism based on sugarcane juicer machine concept. The device can be relocated quickly at desired location at the construction site, as opposed to fixed location type systems, and shall be able to carry tools and construction equipment up to 100kg weight using ropes of different diameters.
SLAPP: Abuse of the right to judicial protection with the aim of restricting freedom of expression

SLAPP (Strategic Lawsuits Against Public Participation) is a phenomenon that has been present around the world for decades, threatening various human rights and freedoms and undermining the very meaning and the purpose of judicial protection of rights. Considering that conducted research indicated a high probability of their presence in the Republic of Serbia, the aim of the paper is to present and analyze the notion of SLAPP, as well as to deliberate over some potential solutions that can be implemented in order to prevent use of this legal tool. After presenting numerous SLAPP examples from comparative case-law and analyzing the SLAPP concept, the paper turns to the rights that are most endangered by the submission of these lawsuits and provides an overview of relevant jurisprudence of the European Court of Human Rights. Results of the research show not only that ratified international instruments require prevention of abuses embodied in SLAPP suits, but also that the real purpose of these lawsuits can be achieved by using other methods, that will be more complicated to suppress. Finally, given that the initiative to combat this legal anomaly has already been launched within the European Union, the paper concludes that the Republic of Serbia should use the momentum and start tackling this issue sooner rather than later.
Research on Green Innovation Design Method of Active Manufacturing Using TRIZ

For the innovation issue in active remanufacturing design process, green innovation design method of active manufacturing is proposed using theory of inventive problem solving (TRIZ). TRIZ conflict resolution principal and environmental quality function deployment are combined to improve the design of parts for remanufacturing using the active remanufacturing association table of design parameters and engineering parameters. The knowledge mapping and extraction mechanism of green innovation design of active manufacturing is established analyzing the existing active remanufacturing design conflicts. The green design conflict resolution method of active remanufacturing integrating TRIZ and knowledge mapping is given and the design scheme is evaluated from aspects of remanufacturing performances, life cycle energy consumption and costs. The appropriate computer-aided design system has been developed which improves efficiency and success rate of the structural green design for active remanufacturing. Finally, the design case of transmission input shaft verified the feasibility of the method.
Ecological Momentary Assessment to Obtain Signal Processing Technology Preference in Cochlear Implant Users

Background: To assess the performance of cochlear implant users, speech comprehension benefits are generally measured in controlled sound room environments of the laboratory. For field-based assessment of preference, questionnaires are generally used. Since questionnaires are typically administered at the end of an experimental period, they can be inaccurate due to retrospective recall. An alternative known as ecological momentary assessment (EMA) has begun to be used for clinical research. The objective of this study was to determine the feasibility of using EMA to obtain in-the-moment responses from cochlear implant users describing their technology preference in specific acoustic listening situations. Methods: Over a two-week period, eleven adult cochlear implant users compared two listening programs containing different sound processing technologies during everyday take-home use. Their task was to compare and vote for their preferred program. Results: A total of 205 votes were collected from acoustic environments that were classified into six listening scenes. The analysis yielded different patterns of voting among the subjects. Two subjects had a consistent preference for one sound processing technology across all acoustic scenes, three subjects changed their preference based on the acoustic scene, and six subjects had no conclusive preference for either technology. Conclusion: Results show that EMA is suitable for quantifying real-world self-reported preference, showing inter-subject variability in different listening environments. However, there is uncertainty that patients will not provide sufficient spontaneous feedback. One improvement for future research is a participant forced prompt to improve response rates.
Neutrophils Mediate Pulmonary Artery Thrombosis In Situ

Pulmonary embolism is a life-threatening condition, which can result in respiratory insufficiency and death. Blood clots occluding branches of the pulmonary artery (PA) are traditionally considered to originate from thrombi in deep veins (usually in legs). However, growing evidence suggests that occlusion of the vessels in the lungs can develop without preceding deep vein thrombosis (DVT). In this work, we used an inferior vena cava (IVC) complete ligation model of DVT in Wistar rats to explore the possibility and mechanisms of PA thrombosis under the conditions where all routes of thrombotic mass migration from peripheral veins are blocked. We demonstrate that rats both with normal and reduced neutrophil counts developed thrombi in the IVC, although, neutropenia caused a substantial decrease in thrombus size and a shift from fresh fibrin toward mature fibrin and connective tissue inside the thrombus. Massive fibrin deposition was found in the PA branches in the majority of DVT rats with normal neutrophil counts, but in none of the neutropenic animals. Neutrophil ablation also abolished macroscopic signs of lung damage. Altogether, the results demonstrate that thrombi in the lung vasculature can form in situ by mechanisms that require local neutrophil recruitment taking place in the DVT setting.
Generation of hiPSC-Derived Skeletal Muscle Cells: Exploiting the Potential of Skeletal Muscle-Derived hiPSCs

Cell therapies for muscle wasting disorders are on the verge of becoming a realistic clinical perspective. Muscle precursor cells derived from human induced pluripotent stem cells (hiPSCs) represent the key to unrestricted cell numbers indispensable for the treatment of generalized muscle wasting such as cachexia or intensive care unit (ICU)-acquired weakness. We asked how the cell of origin influences efficacy and molecular properties of hiPSC-derived muscle progenitor cells. We generated hiPSCs from primary muscle stem cells and from peripheral blood mononuclear cells (PBMCs) of the same donors (n = 4) and compared their molecular profiles, myogenic differentiation potential, and ability to generate new muscle fibers in vivo. We show that reprogramming into hiPSCs from primary muscle stem cells was faster and 35 times more efficient than from blood cells. Global transcriptome comparison revealed significant differences, but differentiation into induced myogenic cells using a directed transgene-free approach could be achieved with muscle- and PBMC-derived hiPSCs, and both cell types generated new muscle fibers in vivo. Differences in myogenic differentiation efficiency were identified with hiPSCs generated from individual donors. The generation of muscle-stem-cell-derived hiPSCs is a fast and economic method to obtain unrestricted cell numbers for cell-based therapies in muscle wasting disorders, and in this aspect are superior to blood-derived hiPSCs.
Distribution of Adiponectin Receptors in the Brain of Adult Mouse: Effect of a Single Dose of the Adiponectin Receptor Agonist, AdipoRON, on Ischemic Stroke

Adiponectin exhibits pleiotropic effects, including anti-inflammatory, anti-apoptotic, anti-oxidant, and neuroprotective ones. Although some studies have documented brain expression in different rodent models of its receptors, AdipoR1 and AdipoR2, their global distribution remains incomplete. Here, we demonstrated that both AdipoR are widely distributed in the brains of adult mice. Furthermore, by double immunostaining studies, we showed that AdipoR1 and AdipoR2 are mainly expressed in neurons and blood vessels. Then, considering the wide distribution of both receptors and the neuroprotective effects of adiponectin, we tested the therapeutic effect of a single injection of the adiponectin receptor agonist, AdipoRON (5 mg.kg−1), 24 h after stroke in a model of middle cerebral artery occlusion technique (MCAO). Under our experimental conditions, we demonstrated that AdipoRON did not modulate the infarct volume, cell death, neuroinflammatory parameters including microglia activation and oxidative stress. This study suggests that a protocol based on multiple injections of AdipoRON at a higher dose after MCAO could be considered to promote the therapeutic properties of AdipoRON on the brain repair mechanism and recovery.
Assessment of Financial Development of Countries Based on the Matrix of Financial Assets

Building an adequate system of indicators to assess the financial development of countries and its practical application can improve the robustness and effectiveness of government decision-making. This paper aims to create such a system. The study used the methods of structured system, comparative, matrix, and gap analysis. The key outcome of the study is a matrix system of indicators for assessing the financial development of countries. This indicator system is based on a matrix of all financial assets. Elements of the matrix of financial assets were calculated in relation to the population and used as indicators of the level of financial development of countries as a whole and in the context of financial instruments and sectors of the economy. Simultaneous recording of financial assets across the entire range of financial instruments and sectors of the economy, as well as their interrelations, is a relatively new direction for financial development assessment. The study produced criteria for the qualitative assessment of the level of the financial development of countries. Testing of the developed matrix system of indicators and criteria for financial development was carried out on current and potential members of OECD (OECD+) for the period 2018–2019. As part of the testing, the level of financial development of the analyzed countries was calculated, their ranking was gauged, and international positions were determined. A structural analysis of the financial development of OECD+ countries in terms of types of financial assets (instruments) and sectors of the economy was carried out. Promising areas of Italy’s financial development have been identified. The test results confirmed that the matrix system of indicators and the developed criteria are an objective and convenient tool for assessing the level of financial development of countries. Their use makes it possible to increase the complexity and quality of the analysis of financial development, and it also forms a platform for making evidence-based and effective decisions in the development of national strategic documents.
S‐ and C‐band modified PIFAs in MIMO arrangement on cylindrical ground plane

An omni‐directional antenna in multiple input multiple output (MIMO) arrangement is presented that covers S‐band (2.3–2.5 GHz) and C‐band (4.4–5.1 GHz) wireless communication applications. One pair of modified PIFA‐like radiating structures is used for each of the two bands. These elements are placed on a cylindrical ground plane with bents which is cut from a cylindrical conducting surface to accommodate a device which has a unique shape. Simulated and measured MIMO parameters such as the total active reflection coefficient (TARC), envelope correlation coefficient (ECC), mean effective gain (MEG), and channel capacity loss (Closs) are computed and presented. Performance results are very satisfactory for a MIMO antenna. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2137–2143, 2016
A kommunkáció rejtett zavara: a pragmatikai kommunikációs zavar

A pragmatikai kommunikációs zavar (PKZ) mint önálló diagnosztikai kategória a 2013-ban kiadott DSM-5-ben jelent meg a nyelvi és kommunikációs zavarok között. A nemzetközi gyakorlatban az 1980-as években írták le először olyan gyermekek tüneteit, akik a felszínen tipikusnak tűnő nyelvfejlődési útjuk ellenére súlyos szociális-kommunikációs és pragmatikai nehézségekkel küzdenek (Rapin‒Allen 1983). Hazánkban jelenleg kezdeti szakaszban jár ennek a fejlődési zavarnak a megés felismerése, szűrése, diagnosztikája, illetve az intervenció módszereinek kidolgozása. A PKZ-val élő gyermekek ‒ a gyakran rejtve maradó fejlődési zavaruk következtében ‒ iskolai előmenetelük során tipikusan fejlődő kortársaikhoz képest egyre nagyobb és látványosabb hátrányba kerülnek, és ez tanulási nehézségekben, magatartási és viselkedési problémákban, figyelmi nehézségekben, szociális és kommunikációs esetlenségben nyilvánul meg. Jelen tanulmány célja a PKZ tüneteinek, hétköznapi megnyilvánulási formáinak a megismertetése a gyakorló pedagógusokkal annak érdekében, hogy felismerjék a tanítványaik között esetleg érintett gyermekeket.
Acoustic correction of monumental churches with ceramic material: The case of the Cathedral of Benevento (Italy)

In this work, soundproof systems for the acoustic correction of large spaces, such as monumental churches, are studied. The Cathedral of Benevento is considered as a case study. Dated back to the seventh century, the church was destroyed during the Second World War and rebuilt in the mid-twentieth century, using marble for the floor and smooth plaster for the side walls. In the current state, the cathedral exhibits an excessive reverberation time (about 10 s) that causes poor understanding of speech and not good listening to musical performances. It is difficult to perform any form of acoustic correction inside the cathedral, since the walls and the ceiling cannot be covered with traditional sound-absorbing material due to architectural and aesthetic reasons. Therefore, the possibility of using ceramic material applied to the side walls for the acoustic correction of low-frequency components and transparent micro-perforated sheets placed under the ceiling for the acoustic correction of medium- and high-frequency components are considered. The work is divided into three phases: in the first phase, measurement of the current acoustic characteristics of the cathedral is performed. In the second phase, sound absorption material is investigated and in the third phase, the effects of insertion of soundproof systems on the acoustic characteristics of the cathedral are theoretically evaluated by means of a room acoustic software.
Uji Aktivitas Antibakteri Kulit Batang Alpukat (Persea americana Mill) Terhadap Bakteri Staphylococcus aureus Dan Escherichia coli

Kasus infeksi disebabkan oleh bakteri atau mikroba yang masuk ke dalam jaringan tubuh dan berkembang biak di dalam jaringan. contoh bakteri yang dapat menyebabkan infeksi adalah Staphylococcus aureus dan Escherichia coli. Tanaman yang dipercaya dapat menghambat pertumbuhan bakteri salah satunya adalah kulit batang alpukat (Parsea Americana Mill). Penelitian antibakteri ini menggunakan teknik difusi cakram. Jenis penelitian eksperimental laboratorium. Menggunakan 7 konsentrasi ekstrak dengan 3 kali pengujian untuk dua jenis bakteri. Ekstrak kulit batang alpukat konsentrasi 20%, 40%, 60%, 80% dan 100%. kontrol positif amoxycillin 50 ml dan control negatif aquades. Analisis data dilakukan secara deskriptif dengan mengukur nilai zona hambat pada uji aktivitas antibakteri untuk bakteri S.aureus dan E.coli. Uji statistik ANOVA juga digunakan untuk penelitian ini. Hasil penelitian menunjukkan bahwa ekstrak kulit batang alpukat memiliki aktivitas antibakteri pada bakteri S.aureus dan E.coli. Hasil yang didapatkan pada penelitian ini menunjukkan bahwa semua konsentrasi memiliki aktivitas antibakeri, namun konsentrasi terbesar yaitu 100% rata-rata nilai zona hambat pada bakteri S.aureus dan E.coli yaitu 12,00 dan 11,33.
Glutathione Peroxidase GPX1 and Its Dichotomous Roles in Cancer

Simple Summary Glutathione peroxidase 1 (GPX1), as one of the most important antioxidant enzymes, maintains cellular redox balance by regulating reactive oxygen species levels. In this review, we summarize and discuss the relationship between GPX1 genetic polymorphisms and cancer susceptibility, as well as the dichotomous roles of GPX1 aberrant expressions in the occurrence and development of human malignancies via various biological mechanisms. Our work may deepen the understanding of the critical clinical values and future directions of GPX1 as a potential prognostic biomarker and novel cancer therapeutic target. Abstract As the first identified selenoprotein, glutathione peroxidase 1 (GPX1) is a widely and abundantly expressed antioxidant enzyme. GPX1 utilizes glutathione as a substrate to catalyze hydrogen peroxide, lipid peroxide, and peroxynitrite, thereby reducing intracellular oxidative stress. The GPX1 gene is regulated at transcriptional, post-transcriptional, and translational levels. Numerous case-control studies and meta-analyses have assessed the association between a functional genetic polymorphism of the GPX1 gene, named Pro198Leu (rs1050450 C>T), and cancer susceptibility in different populations. GPX1 polymorphism has type-specific effects as a candidate marker for cancer risk, but the association between GPX1 variants and cancer susceptibility remains controversial in different studies. GPX1 is abnormally elevated in most types of cancer but has complex dichotomous roles as tumor suppressor and promoter in different cancers. GPX1 can participate in various signaling pathways to regulate tumor biological behaviors, including cell proliferation, apoptosis, invasion, immune response, and chemoresistance. In this review, we comprehensively summarize the controversial associations between GPX1 polymorphism and cancer risks and further discuss the relationships between the aberrant expressions of GPX1 and tumorigenesis. Further studies are needed to elucidate the clinical significance of GPX1 as a potential prognostic biomarker and novel therapeutic target in various malignancies.
House price prediction with gradient boosted trees under different loss functions

ABSTRACT Many banks and credit institutions are required to assess the value of dwellings in their mortgage portfolio. This valuation often relies on an Automated Valuation Model (AVM). Moreover, these institutions often report the models accuracy by two numbers: The fraction of predictions within and range from the true values. Until recently, AVMs tended to be hedonic regression models, but lately machine learning approaches like random forest and gradient boosted trees have been increasingly applied. Both the traditional approaches and the machine learning approaches rely on minimising mean squared prediction error, and not the number of predictions in the and range. We investigate whether introducing a loss function closer to the AVMs actual loss measure improves performance in machine learning approaches, specifically for a gradient boosted tree approach. This loss function yields an improvement from to of predictions within of the true value on a data set of transactions from the Norwegian housing market between 2013 and 2015, with the biggest improvements in performance coming from the lower price segments. We also find that a weighted average of models with different loss functions improves performance further, yielding of the observations within of the true value.