Miracle-dz/UniFAR-FTUs huggingface dataset:
Automation in automotive industries : recent developments

1 Introduction. - 2 Industry clockspeed and competency chain design: an introductory essay. - 3 New perspectives on automation. - 4 Competitive strategies, industrial models and assembly automation templates. - 5 Automation and Inertia. - 6 Automation strategies at the first-tier suppliers in Japan. Process development and product trajectory. Hypothesis on the supplier-assembler relationship. - 7 Anticipating problems with manufacturing during the product development process. - 8 Diffusion patterns of lean practices: lessons from the European auto industry. - 9 The transfer of organizing principles in the world auto industry: Cross-cultural influences on replication at Opel Eisenach. - The Authors of the Book.
Immobilization of Enzymes by Polymeric Materials

Enzymes are the highly efficient biocatalyst in modern biotechnological industries. Due to the fragile property exposed to the external stimulus, the application of enzymes is highly limited. The immobilized enzyme by polymer has become a research hotspot to empower enzymes with more extraordinary properties and broader usage. Compared with free enzyme, polymer immobilized enzymes improve thermal and operational stability in harsh environments, such as extreme pH, temperature and concentration. Furthermore, good reusability is also highly expected. The first part of this study reviews the three primary immobilization methods: physical adsorption, covalent binding and entrapment, with their advantages and drawbacks. The second part of this paper includes some polymer applications and their derivatives in the immobilization of enzymes.
A Megawatt Power Module for Ship Service - Supplement. Volume 1: Program Technical Report

Abstract : This report is Volume 1 of a three volume Final Report on ONR Contract N00014-07-C-0361. Activities documented in this report were performed as a supplement to ONR Grant N00014-06-01-0886. The two programs address the use of energy storage and high speed power generation to reduce fuel consumption of DDG51 Arleigh Burke class ship service generation system by improving efficiency and permitting safe operation on one gas turbine generator set. In the event of turbine failure, the energy storage unit will provide power for critical loads until a second gas turbine generator set can be brought online. Volume 1 of the Final Report documents trade studies and preliminary design of the energy storage flywheel and associated motor/generator, the final system topology, high fidelity modeling and simulation activities, and top level platform integration issues. Volume 2 of the Final Report is a User's Manual for the high fidelity MatLab Simulink system simulation model. Volume 3 of the Final Report documents projected fuel savings, a preliminary interface control matrix, a ship installation study, and a technology development plan.
S-adenosylmethionine Decarboxylase 1 Participates in PM2.5 Exposure Induced Neuronal Apoptosis via Mitochondria-Mediated Pathway

Background: Fine particle (Particulate matter 2.5, PM2.5), as the primary ambient pollutant, is considered harmful to some neurodegenerative diseases, while the specific biochemical mechanism underlying is still unrevealed. Neuronal apoptosis is believed the crucial event in neurodegenerative pathogenesis, but evidence supporting neuronal apoptosis as PM2.5 induced neuronal injury is insufficient. S-adenosylmethionine decarboxylase 1 (AMD1) and its related spermidine synthesis have been shown to participate in cellular apoptosis, but its role in PM2.5 exposure induced neuronal apoptosis was rarely reported. To better understand contribution of AMD1 activity and spermidine in PM2.5 exposure induced neuronal apoptosis, may provide novel therapeutic and preventive targets for air pollution associated neurodegenerative diseases.Methods: In the current work, sixteen C57BL/6 male mice were randomly divided into ambient PM2.5 chamber or filtered air chamber, and the mouse model of whole-body ambient PM2.5 chronic exposure was established. Behavioral and cognitive ability, together with corresponding biomedical index were recorded and tested to evaluated neurotoxicity by PM2.5 exposure in mice. In parallel, PC12 cells and primary hippocampal neurons were applied for PM2.5 treatment to explore the possible cellular and molecular mechanism which may be critically involved in the process. AMD1 activity and cellular spermidine content were modulated by pharmacological approach to examine their participation in PM2.5 triggered neuronal apoptosis, followed by better examination of typical index for mitochondrial membrane potential and mitochondrial-mediated apoptosis pathway signaling.Results: Chronic ambient PM2.5 exposure attenuated spatial learning and memory ability, and triggered neuronal apoptosis together with increased expression of apoptosis-related Bax/Bcl-2 and cleaved caspase-3. PM2.5 exposure impaired AMD1 expression and spermidine synthesis. AMD1 inhibition could mimick PM2.5 exposure induced neuronal apoptosis. Spermidine supplementation rescued against neurotoxicity and inhibited PM2.5 induced apoptosis, in which mitochondrial pathway signaling.Conclusions: Chronic real-time exposure to ambient PM2.5 led to the reduced the ability of spatial learning and memory in mice. Neuronal apoptosis was the key event in the process of neurodegenerative development induced by PM2.5 exposure. AMD1 and spermidine participated in neuronal apoptosis induced by PM2.5 exposure, which was at least partially dependent on mitochondria mediated pathway.
Athens as a Major Congress Destination and the Role of Professional Congress Organizers (PCOs)

The aim of this study was to investigate the factors that contribute to the attraction of major congress events in Athens, Greece and the role of professional congress organizers (PCOs) in this process. To meet this aim we used a questionnaire distributed through Google Forms to 30 PCO executives in the major Athens area. The questionnaire used qualitative and quantitative methods and contained both open and closed answer questions. Result showed that most PCOs organize local events with medical congresses being the main activity (96.7%). The vast majority of PCO’s use the social media or digital marketing to approach clients (with Facebook being the principal tool, 89.7%), as only 33.3% of the Greek PCOs can afford to participate as exponents to major congress tourism exhibitions worldwide because of their small size and limited resources. This means that the role of PCOs in the attraction of major congress events in Athens is limited. Additionally, PCOs revealed that most congresses organized in Athens last only 1-2 days (74%), with a mean number of participants on average about 300 people. Respondents also think that Athens can become a major congress tourism destination as it has certain advantages (good congress infrastructure, excellent weather, priceless archaeological sites, a unique sea front, night life, good shopping places and opportunities for short excursions) that need to be exploited, as well as the Athens Visitor & Conventions Bureau of which they share a positive view. The current study shows that conjoint efforts of the state, the private sector and certain congress tourism stakeholders are needed (adopting advanced development strategies and using intensive marketing tools, including ambassador programs and adequate bidding processes) in order for Athens to attract international congress events and be established as a major congress tourism destination.
Historical abundance and distribution of the native flat oyster (Ostrea angasi) in estuaries of the Great Southern region of Western Australia help to prioritise potential sites for contemporary oyster reef restoration

Reefs of the flat oyster ( Ostrea angasi ) were once common along the southern coasts of Australia. Historical and current literature relating to O. angasi was used to identify bays and estuaries where this species once existed. In many estuaries of Western Australia, current populations are significantly lower than historical levels, including in Princess Royal Harbour and Oyster Harbour, near Albany. The main causes of the declines included overfishing, combined with the use of destructive fishing methods, such as dredging. Other factors, suchas sedimentation, increased nutrient input and loss of seagrass, may have contributed to the loss of oyster reefs, and may have inhibited effective recovery. The possible impact of the protozoan pathogen Bonamia exitiosa is uncertain, although it is known to have severely affected flat oyster populations in other parts of the world. The fact that O. angasi reefs in Oyster Harbour did not recover after the fishery ceased suggests that restoration activities, aimed at restarting the ecosystem services that the oyster reefs once provided, should be undertaken. This paper suggests that the historical presence of O. angasi could be an effective starting point for prioritising potential restoration sites and details the prioritisation protocol that was used in recent restoration activities.
Wound Dressings: Results of Studies Over 13 Years

Many materials were used in and on experimentally inflicted wounds in many studies over a 13-year period. No material prevented decay. The individual tree had a greater effect on the wound than the treatments. Some individual trees of a species closed and compartmentalized wounds rapidly and effectively, regardless of treatment, while other trees did not close and compartmentalize treated or control wounds. The width of healthy wood behind wounds in red maple was the major factor affecting the course of the wound. Results are given from wounds on 275 treated and dissected trees.
Digital wet laboratories: blended learning to improve student learning

To create great learning environments we need to actively engage our learners. Microbiology laboratory work experience for students is a powerful motivator; students returning from placement back to university often buzz with stories and look forward to a future place in industry. Unfortunately, opportunities for working in industry are limited and thus the next best thing is to ensure that university laboratory practicals also actively engage students. Traditional laboratory practical classes can be supported by and better simulate the activities undertaken in the workplace through the blending of computer-aided instruction with wet practical exercises.
TOWARD AUTOMATION OF MOBILITY MEASURES IN PORTLAND, OREGON: MICROSCOPIC VALIDATION OF ARCHIVED FREEWAY SENSOR DATA

Intelligent transportation systems (ITS) provide the surveillance infrastructure for both advanced transportation management and advanced traveler information. Having shifted toward a much more intensified data rich environment, it is now possible to consider automatically generating mobility measures as part of an overall traffic management and information system. Many regions use inductive loop detector technology for measuring key traffic parameters such as flow, occupancy and average speed. Mobility-related measures can be produced from these data, including vehicle miles traveled, vehicle hours traveled, average speed, travel time, delay and other nationally accepted parameters that measure transportation system performance. The Portland, Oregon metropolitan region is developing a system to automate the generation of mobility measures using inductive loop detector data. In this paper, we describe a rigorous, microscopic validation process that has been developed to validate the inductive loop detector data using ground truth video. In addition, we present several methods for converting the validated data to useful visualizations which are helpful for transportation management and operations.
CRISP(R)ation musculaire

Les dystrophies musculaires sont un ensemble de pathologies musculaires rares, caractérisées par une faiblesse et une dégénérescence progressive du muscle. Ce sont des maladies d’origine génétique causées par la mutation d’un ou de plusieurs gènes impliqués dans les fonctions musculaires. Malgré des progrès significatifs réalisés dans le champ des biothérapies au cours des dernières années, il n’existe pas, à ce jour, de traitement curatif disponible pour ces pathologies. Les études menées depuis la découverte de l’outil d’édition génomique CRISPR-Cas9 ont néanmoins permis des avancées significatives et prometteuses dans le traitement des dystrophies musculaires. Le système CRISPR-Cas9 permet une édition stable et permanente du génome et doit permettre d’éviter les traitements longs et répétitifs. Dans cette revue, nous aborderons les dernières avancées thérapeutiques utilisant le système CRISPR-Cas9 dans le cadre des dystrophies musculaires d’origine génétique.
Open Shortest Path First (OSPF)

The purpose of routing protocols is to learn of available routes that exist on the enterprise network, build routing tables and make routing decisions. Some of the most common routing protocols include IGRP, EIGRP, OSPF, IS-IS and BGP. There are two primary routing protocol types although many different routing protocols defined with those two types. Link state and distance vector protocols comprise the primary types. Distance vector protocols advertise their routing table to all directly connected neighbors at regular frequent intervals using a lot of bandwidth and are slow to converge. When a route becomes unavailable, all router tables must be updated with that new information. The problem is with each router having to advertise that new information to its neighbors, it takes a long time for all routers to have a current accurate view of the network. Distance vector protocols use fixed length subnet masks which aren't scalable. Link state protocols advertise routing updates only when they occur which uses bandwidth more effectively. Routers don't advertise the routing table which makes convergence faster. The routing protocol will flood the network with link state advertisements to all neighbor routers per area in an attempt to converge the network with new route information. The incremental change is all that is advertised to all routers as a multicast LSA update. They use variable length subnet masks, which are scalable and use addressing more efficiently.
KETERLIBATAN KELUARGA DALAM MANAJEMEN, KEPEMILIKAN KELUARGA, DAN KINERJA PERUSAHAAN: BUKTI EMPIRIS DARI BURSA EFEK INDONESIA

Informasi Naskah Abstrak Diterima: 09 Oktober Revisi: 11 Oktober Terbit: 16 Desember The objective of this study is to examine the effect of family involvement in firm’s management and family ownership on financial performance. The sample of this study are 8 family firms that listed in Indonesian stock exchange during 2012-2015. This research used multiple regression technique. The results of this study indicated that family ownership had a negative effect on campanies financial performance, while the family involvement in the firm’s management had no significant effect on campanies financial performance Kata Kunci: Family Ownership, Family Involvement, Financial Performance
First Steps in Bridging the Gap between the Virtual Learning Environment and Social Media - Students Attitudes

Social media has a growing history of use within an educational context, for no other reason than the student sitting in a lecture theatre may be tweeting their friends on a smartphone. This paper describes some initial work on harnessing the power of social media to draw students into a virtual learning environment (VLE). The work has had two main halves with the first focussed on how students currently use social networks and whether they would “give permission” to have academic activities “marketed” to them using these channels. The second half looks at how RSS can be used as a basic mechanism to “plumb” the VLE into social networks so that students can be alerted to any new activity happening within the VLE, and the design principles required to ensure barriers are not put up between the VLE and social media.
Dynamic interplay between the intermediate filament protein nestin and Cyclin-dependent kinase 5

Cellen har ett s.k. cytoskelett som bl.a. ger stadga at cellen och deltar i dess form- och rorelsefunktioner. Intermediarfilamenten ar en viktig del av cytoskelettet och de har lange varit kanda for sina vasentliga roller i att uppratthalla den cellulara organisationen och vavnadernas integritet. Pa senare ar har man insett att intermediarfilamenten har en storre funktionell mangsidighet an man tidigare tankts sig, i och med att en rad olika studier har visat betydelsen av intermediarfilamenten vid olika signaleringprocesser. Dessa proteinnatverk samverkar namligen med kinaser och andra viktiga signalfaktorer och deltar darmed i cellens signaleringmaskineri. Intermediarfilamentproteinet nestin anvands ofta som en markor for stamceller men dess fysiologiska funktioner ar i stort sett okanda. Interaktion mellan nestin och ett signalkomplex bestaende av cyklin-beroende kinas 5 (eng. Cyclin-dependent kinase, Cdk5) och dess aktivatorprotein p35 upptacktes i vart laboratorium fore denna avhandling paborjades. Darfor var syftet med min avhandling att undersoka den funktionella betydelsen av nestin i regleringen av Cdk5/p35 komplexet. Cdk5 ar ett multifunktionellt kinas som reglerar bade utvecklingen och stressreaktioner i nerver och muskler. Vi visade att nestin skyddar neuronala stamceller under oxidativ stress genom dess formaga att hamma Cdk5s skadliga aktivitet. Genom att forankra Cdk5/p35 komplexet, reglerar nestin den subcellulara lokaliseringen av Cdk5/p35 och minskar klyvningen av p35 till den mer stabila aktivatorn p25. Vi demonstrerade ocksa aktiveringsmekanismen for Cdk5 under differentiering av muskelceller. Proteinkinas C zeta (PKCzeta) avslojades ha en formaga att accelera klyvningen av p35 till p25, och darmed oka aktiviteten hos Cdk5. Nestin kunde genom sin formaga att reglera Cdk5 signalkomplexet styra muskelcellernas differentiering. Denna doktorsavhandling har pa ett avgorande vis okat forstaelsen av de reglerande mekanismer som styr Cdk5 aktivering. Avhandling presenterar nestin och PKCzeta som kritiska faktorer i denna reglering. Vidare innehaller avhandlingen ny information om de cellulara funktionerna hos nestin som vi har visat vara en viktig reglerare av cellernas overlevnad och differentiering.
Using Portal Technology for Managing Information in an Aerospace Manufacturing Environment

Portal technologies are becoming increasingly popular as a way to manage large amounts of complex information. This presentation is an overview of the development processes used on a portal project for managing information in an aerospace manufacturing environment. The focus here is on the pre-production usability research, which included interviews with and observations of content owners, content users, management and others, to document processes, terminology, and artifacts; user navigation was also analyzed. The final results were recommendations for a documents directory structure (taxonomy), content for the portal pages based on user profiles, prototype mock-ups, and recommendations based on user navigation.
Standardized Measurement Error: A Universal Measure of Data Quality for Averaged Event-Related Potentials (v_r1)

Event-related potentials (ERPs) can be very noisy, and yet there is no widely accepted metric of ERP data quality. Here we propose a universal measure of data quality for ERP research—the standardized measurement error (SME)—which is a special case of the standard error of measurement. Whereas some existing metrics provide a generic quantification of the noise level, the SME quantifies the data quality (precision) for the specific amplitude or latency value being measured in a given study (e.g., the peak latency of the P3 wave). It can be applied to virtually any value that is derived from averaged ERP waveforms, making it a universal measure of data quality. In addition, the SME quantifies the data quality for each individual participant, making it possible to identify participants with low-quality data and “bad” channels. When appropriately aggregated across individuals, SME values can be used to quantify the combined impact of the single-trial EEG noise and the number of trials being averaged together on the effect size and statistical power in a given experiment. If SME values were regularly included in published papers, researchers could identify the recording and analysis procedures that produce the highest data quality, which could ultimately lead to increased effect sizes and greater replicability across the field.
R248Q mutation of p53 alters molecular tra�cking and targeted drug responses in high-grade serous ovarian carcinoma

Background p53 mutations are detected in up to 96% of high-grade serous ovarian carcinoma (HGSOC). Moreover, mutant p53 may cause oncogenic gain-of-function phenotypes in sustained activation of epidermal growth factor receptor (EGFR) signaling. In this study, we investigated whether p53 mutation could affect EGFR-related signaling and the corresponding therapeutic strategies in HGSOC.Methods For this study, we selected the p53 R248Q mutant (p53 R248Q ), which has the highest mutation frequency in ovarian cancer. Since we have previously demonstrated that the combined inhibition of EGFR and MDM2-p53 pathways by ge�tinib and JNJ-26854165 exerts a strong synergistic lethal effect on p53-mutated HGSOC cells, the ge�tinib and JNJ-26854165 responses in different p53 status cells were evaluated by cell viability and target protein expression assays.Results We showed that the phosphorylation of AKT, a critical molecule of EGFR downstream signaling, increased signi�cantly when p53 R248Q was transiently overexpressed. Immunocytochemistry analysis further showed that upon p53 R248Q overexpression, several AKT-dependent mediators translocate in unique patterns within the cell. Subsequent analysis revealed that under the combined inhibition of ge�tinib and JNJ-26854165, the cytonuclear tra�cking of EGFR and MDM2 is disrupted. Moreover, when we further compared ge�tinib and JNJ-26854165 responses in different p53 status cells, we found that the sensitivity to the single- or combined-inhibition treatments is also altered in p53 R248Q -overexpressing cells.Conclusions Our �ndings suggest that the R248Q mutation of p53 causes signi�cant changes in signaling transduction, molecular tra�cking and drug responses, which help to advance our understanding of p53 and to improve therapeutic strategies for HGSOC.
Modeling and characterization of substrate resistance for deep submicron ESD protection devices

As device dimensions continue to shrink, higher current densities and lower voltage tolerances make ESD, or Electrostatic Discharge, an increasingly important issue to guard against for ensuring reliability. Industry data show that one-third of all customer returns are due to ESD. IC chips are protected against ESD by on-chip protection circuits, which are connected between the I/O pads and the internal circuitry. The protection circuit, which consists of protection devices, is designed to rapidly discharge high current in an ESD event. Typically, the design of ESD protection circuits is an empirical approach. Several candidate circuits are fabricated, characterized, and evaluated for key physical and performance parameters using known testing techniques. Different combinations of device geometries and process technologies are evaluated until a suitable circuit with the desired characteristics is found. This resource intensive design approach clearly motivates a simulation based solution which enables quicker turnaround as well as obvious cost-savings in materials and resources.