Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of certain trace minerals in oxidative stress, inflammation, CD4/CD8 lymphocyte ratios and lung function in asthmatic patients

Background Asthma is associated with increased inflammation, oxidative stress and abnormal immune system function. We determined the distributions of several essential trace minerals and assessed their relationships to factors that are associated with the pathophysiological status of patients with mild/moderate asthma. Methods We enrolled 25 asthmatic patients and 25 healthy subjects. We measured: blood trace minerals, zinc (Zn), copper (Cu) and selenium (Se); oxidative stress markers thiobarbituric acid reactive substances (TBARS); antioxidant enzyme activities; percentages of CD4 and CD8 lymphocyte subsets; high-sensitivity C-reactive protein (hs-CRP); and a lung function index (FEV1/FVC%). Results Compared with healthy subjects, asthmatics had lower concentrations of Zn and Se; higher Cu concentrations, and Cu/Zn and Cu/Se ratios; and lower antioxidant enzyme glutathione peroxidase (GPx), glutathione reductase (GR) and catalase activities. Significantly increased concentrations of hs-CRP, TBARS and CD4/CD8 lymphocyte ratios were also observed. Furthermore, plasma TBARS or hs-CRP concentrations were negatively associated with Se concentrations, but were positively associated with Cu/Se ratios. CD4/CD8 lymphocyte ratios were inversely correlated with Se, while it was positively correlated with Cu/Se ratio. FEV1/FVC% was also significantly correlated with Se concentrations, and Cu/Se and Cu/Zn ratios. Conclusions Abnormal distributions of these trace minerals may aggravate oxidative damage and inflammation, increased CD4/CD8 lymphocyte ratios and decreased lung function in asthma.
Genetic control of cell fate specification in Drosophila peripheral nervous system.

INTRODUCTION . 373 PROGRESSIVE DETERMINATION MODEL OF THE GENESIS OF EXTERNAL SENSORY ORGAN . 374 PRONEURAL GENE . 375 The achaete-scute Complex . 375 The Regulation of Proneural Gene Activity . 376 Is the Concept of "Proneural Gene" Generally Applicable? 377 Do Proneural Genes Conrrol Neuronal Type in PNS? 378 SINGLING OUT OF NEURAL PRECURSORS. 379 DIFFERENTIATION AND SPECIFICATION OF NEURAL PRECURSORS . 380 The Role olda in PNS Development . 381 The Role of da in Embryonic CNS Development . 382 THE FATE OF THE PROGENY OF SENSORY ORGAN PRECURSORS. 382 Extrinsic Mechanism: Cell-Cell Interaction . 383 Inrrinsic Mechanism: Asymmetric Distribution of numb Protein. 385 How Do the Extrinsic Mechanism and the Intrinsic Mechanism Interphase? 386 PERSPECTIVE . 388
Microsporidia of the Genus Trachipleistophora—Causative Agents of Human Microsporidiosis: Description of Trachipleistophora anthropophthera N. Sp. (Protozoa: Microsporidia)

Trachipleistophora anthropophthera n. sp. , was found at autopsy in the brain of one and in the brain, kidneys, pancreas, thyroid, parathyroid, heart, liver, spleen, lymph nodes, and bone marrow of a second patient with AIDS. The parasite is similar to the recently described T. hominis Hollister, Canning, Weidner, Field. Kench and Marriott, 1996, in having isolated nuclei, meronts with a thick layer of electron dense material on the outer face of their plasmalemma and sporogony during which spores are formed inside a thick‐walled sporophorous vesicle. In contrast to T. hominis, this species is dimorphic as it forms two kinds of sporophorous vesicles and spores: Type I‐round to oval polysporous sporophorous vesicle. 7‐10 μm in size, usually with eight spores (3.7 × 2.0 μm), thick endospores, subterminal anchoring disc and anisofilar polar filaments forming seven thicker and two thinner terminal coils. This type of sporophorous vesicle is associated with 25‐30 nm filaments extending into the host cell cytoplasm. Type II—smaller, bisporous sporophorous vesicle (4‐5 times 2.2‐2.5 μm) with two, nearly round, thin‐walled spores, 2.2‐2.5 × 1.8‐2.0 μm in size, having 4‐5 isofilar coils. No outside filamentous elements are associated with the bisporous sporophorous vesicle. Both types of sporophorous vesicles were common in the infected brain tissue and could be found within the same cell. The newly described species, together with T. hominis and previously reported Pleistophora‐like parasites from human muscle, likely represent a group of closely related human microsporidia.
Developing a framework to facilitate the assessment of asset management information quality in facilities management operations

Information quality issues have taken an increased importance in academia and industry and have many causes attributed to it. Poor information quality presents significant costs to an organisation, financially and non-financially. However, the issue of information quality has not been explored in depth in the field of facilities management. Thus, within the context of facilities management, this has led to failures in asset management programs undertaken by facilities management organisations and present a significant challenge in the decision-making process by facility managers. Achieving improved asset information quality in facility management operations is thus of immense importance to stakeholders in facilities management. To this end, various methods and frameworks have been developed to assess and improve information quality, but these have very limited scope and not applicable in facilities management organisation undertaking asset management. To this end, this research aims to evaluate the quality of information and determine what factors impact information quality of asset management programs in the facilities management domain. The research adopts an exploratory mixed-method methodology, which allows data to be collected and analysed using qualitative and quantitative techniques to provide greater insight of the phenomenon in facility management operations. The qualitative approach uses thematic analysis to determine what factors affect the quality of information from the information, organisation, and people domain respectively. The results from this analysis show that factors affecting information quality of asset management programs is multidimensional. In addition, 71 information quality attributes has been identified from the qualitative analysis. In the quantitative phase, principal component analysis (PCA) with direct oblimin rotation, ANOVA, and measure of central tendency (MCT) techniques were adopted to identify the specific dimensions of information quality in asset management, the effect of the structure of the organisation on information quality, and the prevalence of information quality issue in asset management respectively. The results from the analysis identified 12 information quality dimensions which was grouped into seven (7) categories. Also a high prevalence of information quality issue experienced by facilities management professionals was observed with a mean value of 7.90 and median value of 8.00 and standard deviation of 1.467 which was normally distributed. Further analysis indicated that the hierarchical structure of the organisation had an effect on information quality which was statistically significant. Based on the result of the analysis, a framework, using a perceptual map premised on multi-dimensional scale (MDS) technique, has been developed that seeks to assess the quality of information of asset management programs in facilities management.
Molecular organization and function of the complement system.

PER SPE CTIVE S AN D SUMMARY . 321 THE PR OTE IN S. 324 C3, C4, and CS. 324 C3blC4b-Binding Proteins . 325 Serine Proteases . 327 Channel-Forming Proteins . 328 Other Regulatory Binding Proteins. 330 THE M ULTIPLE B IN DING SITE S OF C3 331 THE A LTER NA TIVE PATHWA y . 333 The Initial C3 Convertase. 334 The Target Cell-Bound C31CS Convertase . 334 Discrimination and Amplification . 335 T HE CLASSICAL PAT HWA y . 337 Structure. Activation. and Control of CI . 337 Formation, Structure, and Control of the C31CS Convertase . 338 THE MEMB RANE A TTA CK COMP LE X 3 39 Molecular Assembly. 339 Control of MAC Channel Formation . 341 MEMBRANE ATTA CK BY CYT OTOXI C L yMP HOCyTES . 342
Supplementary material for Convex Global 3 D Registration with Lagrangian Duality

1. Generalized distance function 2 1.1. Point-to-point . 2 1.2. Point-to-line . 2 1.3. Point-to-plane . 3 1.4. Discussion . 3
Biotechnological approach : an option for integrated weed management in crop production

Crops made resistant to herbicides by biotechnology are being widely adopted in various parts of the world. From the genesis of commercialization in 1996 to 2011, herbicide tolerance has consistently been the dominant trait. Those containing transgenes that impart resistance to post-emergence, non-selective herbicides such as glyphosate and glufosinate will have the major impact. These products allow the farmer to more effectively use reduced or no-tillage cultural practices, eliminate use of some of the more environmentally suspect herbicides and use fewer herbicides to manage nearly the entire spectrum of weed species. In some cases, non-selective herbicides used with herbicide resistant crops reduce plant pathogen problems because of the chemicals’ toxicity to certain microbes. Herbicide tolerant crops can be produced by either insertion of a “foreign” gene (transgene) from another organism into a crop, or by regenerating herbicide tolerant mutants from existing crop germplasm.Biotech crops reached 160 million hectares, up 12 million hectares on 8% growth, from 2010 and 94 fold increase in hectarage from 1.7 million hectares in 1996 to 160 million hectares in 2011, makes biotech crops the fastest adopted crop technology in the history of modern agriculture. The inclusion of several transgenes in a single hybrid or variety commonly referred as stacked genes or stacked traits. For example, some corn and cotton hybrids have been genetically engineered to contain two transgenes, one for insect tolerance and another for herbicide tolerance (e.g., Bt/glyphosate, or Bt/glufosinate). Furthermore, some corn hybrids have three traits, two for herbicide tolerance and one for insect tolerance (e.g., Liberty, Clearfield, and Bt). Stacked traits occupied ~25% of the global 160 million hectares. From the genesis of commercialization in 1996 to 2011, herbicide tolerance has consistently been the dominant trait. In 2011, herbicide tolerance deployed in soybean, maize, canola, cotton, sugar beet and alfalfa, occupied 59% or 93.9 million hectares of the global biotech area of 160 million hectares. In 2011, the stacked double and triple traits occupied a larger area (42.2 million hectares, or 26% of global biotech crop area) than insect resistant varieties (23.9 million hectares) at 15%. The stacked genes were the fastest growing trait group between 2010 and 2011 at 31% growth, compared with 5% for herbicide tolerance and 10% for insect resistance. Over the past few years, several herbicide resistant crops (HRCs), both transgenic and non-transgenic, have become available in many countries for commercial cultivation. But in India, the technology of herbicide tolerant crops is in initial stage of field evaluation. Efforts have been made to evaluate and consolidate the agronomic management and advantages of herbicide tolerant transgenic crops.
Hysteroscopic tissue removal systems for the treatment of intrauterine pathology: a systematic review and meta-analysis

Background The use of mechanical tissue removal systems is more frequently implemented as the first line approach for the treatment of intrauterine pathology. Scientific evidence is provided that their use is easier and faster than the conventional resectoscope. It is necessary to objectively evaluate the results on tissue removal systems for the treatment of endometrial pathology as the reports in the literature are still conflicting. Objective To review and compare mechanical hysteroscopic tissue removal systems (Truclear®, Myosure® or IBS®) versus conventional bipolar and monopolar resectoscopy for the treatment of polyp and myoma removal. Operation time, completeness of tissue removal, complication rate, fluid deficit, tolerability and learning curve were evaluated. Methods Electronic databases PubMed; Medline and Web of Science were searched for papers published from 1st January 2010 to 1st May 2019 using terms: (“hysteroscopic” or “hysteroscopy” or “hysteroscopic surgery”) and (“myoma” or “polyps”). Studies were included if they were retrospective, observational and prospective randomized clinical controlled trials if they investigated the techniques between the tissue removal systems (Truclear®, Myosure® or IBS®) and conventional resectoscopy for the treatment of intrauterine pathology. Data were extracted from the included studies by two independent reviewers. Meta-analysis was performed by Rev Man 5 software (Cochrane Collaboration, London, UK). Results: Overall, 498 patients were analysed from five studies in which there was no difference in age and size of pathology treated either by the hysteroscopic tissue removal systems and the conventional resectoscope. Hysteroscopic tissue removal systems showed a significantly higher success rate of complete endometrial pathology removal (P=0.002) and a significantly shorter operation time for polyp removal (P<0.0001) compared to conventional resectoscopy. No significant differences, in terms of complications rate, were found (P=0.09). The fluid deficit was significantly higher in the tissue removal system group, compared to conventional resectoscopy (P=0.02). Conclusion Hysteroscopic tissue removal systems showed a major advantage in successful removal of the pathology and total operation time. It is likely that the tissue removal systems are more accessible and have a lower complication profile including perforation, via falsa and bleeding due to its specific action mechanism and shorter operation time but higher-quality trials will be required to confirm this hypothesis.
Manufacturing and Assessment of Electrospun PVP/TEOS Microfibres for Adsorptive Heat Transformers

A new adsorbent coating for the adsorber unit of an adsorption heat pump made of hybrid, organic–inorganic microfibres was prepared and characterized. Different coatings were obtained by the electrospinning of polyvinylpyrrolidone (PVP) solutions added with different quantities of tetraethyl orthosilicate (TEOS). PVP is a polymer with water adsorption capability and the TEOS addition allowed to increase the thermal stability of microfibres. The aim, indeed, was to preserve the polymeric structure of microfibres in order to obtain coatings with high flexibility and mechanical strength. The results demonstrated that TEOS concentrations in the range of 5–13 wt. % produced microfibre coatings of non-woven textile structure with both good water affinity and good thermal stability. SEM images of coatings showed that the deposited microfibre layers have both a high surface area and a high permeability representing a significant advantage in adsorption systems.
Untangling causality in midlatitude aerosol–cloud adjustments

Abstract. Aerosol–cloud interactions represent the leading uncertainty in our ability to infer climate sensitivity from the observational record. The forcing from changes in cloud albedo driven by increases in cloud droplet number (Nd) (the first indirect effect) is confidently negative and has narrowed its probable range in the last decade, but the sign and strength of forcing associated with changes in cloud macrophysics in response to aerosol (aerosol–cloud adjustments) remain uncertain. This uncertainty reflects our inability to accurately quantify variability not associated with a causal link flowing from the cloud microphysical state to the cloud macrophysical state. Once variability associated with meteorology has been removed, covariance between the liquid water path (LWP) averaged across cloudy and clear regions (here characterizing the macrophysical state) and Nd (characterizing the microphysical) is the sum of two causal pathways linking Nd to LWP: Nd altering LWP (adjustments) and precipitation scavenging aerosol and thus depleting Nd. Only the former term is relevant to constraining adjustments, but disentangling these terms in observations is challenging. We hypothesize that the diversity of constraints on aerosol–cloud adjustments in the literature may be partly due to not explicitly characterizing covariance flowing from cloud to aerosol and aerosol to cloud. Here, we restrict our analysis to the regime of extratropical clouds outside of low-pressure centers associated with cyclonic activity. Observations from MAC-LWP (Multisensor Advanced Climatology of Liquid Water Path) and MODIS are compared to simulations in the Met Office Unified Model (UM) GA7.1 (the atmosphere model of HadGEM3-GC3.1 and UKESM1). The meteorological predictors of LWP are found to be similar between the model and observations. There is also agreement with previous literature on cloud-controlling factors finding that increasing stability, moisture, and sensible heat flux enhance LWP, while increasing subsidence and sea surface temperature decrease it. A simulation where cloud microphysics are insensitive to changes in Nd is used to characterize covariance between Nd and LWP that is induced by factors other than aerosol–cloud adjustments. By removing variability associated with meteorology and scavenging, we infer the sensitivity of LWP to changes in Nd. Application of this technique to UM GA7.1 simulations reproduces the true model adjustment strength. Observational constraints developed using simulated covariability not induced by adjustments and observed covariability between Nd and LWP predict a 25 %–30 % overestimate by the UM GA7.1 in LWP change and a 30 %–35 % overestimate in associated radiative forcing.
Widespread targeting of nascent transcripts by RsmA in Pseudomonas aeruginosa

Significance Members of the CsrA/RsmA family of global posttranscriptional regulators play critical roles in the control of virulence in a variety of bacteria. These regulators often function to inhibit the translation of target mRNA species and have been thought to act by binding full-length transcripts. Here we show that in the opportunistic pathogen Pseudomonas aeruginosa, RsmA associates with hundreds of transcripts as they are being synthesized by RNA polymerase, some of which are also targeted by another global posttranscriptional regulator called Hfq. Our findings identify which transcripts in P. aeruginosa are targeted by RsmA, reveal connectivity between RsmA and Hfq in this organism, and suggest that the cotranscriptional level of regulation may be an important one for this class of regulator. In the opportunistic pathogen Pseudomonas aeruginosa, RsmA is an RNA-binding protein that plays critical roles in the control of virulence, interbacterial interactions, and biofilm formation. Although RsmA is thought to exert its regulatory effects by binding full-length transcripts, the extent to which RsmA binds nascent transcripts has not been addressed. Moreover, which transcripts are direct targets of this key posttranscriptional regulator is largely unknown. Using chromatin immunoprecipitation coupled with high-throughput DNA sequencing, with cells grown in the presence and absence of the RNA polymerase inhibitor rifampicin, we identify hundreds of nascent transcripts that RsmA associates with in P. aeruginosa. We also find that the RNA chaperone Hfq targets a subset of those nascent transcripts that RsmA associates with and that the two RNA-binding proteins can exert regulatory effects on common targets. Our findings establish that RsmA associates with many transcripts as they are being synthesized in P. aeruginosa, identify the transcripts targeted by RsmA, and suggest that RsmA and Hfq may act in a combinatorial fashion on certain transcripts. The binding of posttranscriptional regulators to nascent transcripts may be commonplace in bacteria where distinct regulators can function alone or in concert to achieve control over the translation of transcripts as soon as they emerge from RNA polymerase.
Structure Image Method for Simulating Multi-Room Acoustics and Applications

1 Glossary 3 Abbreviations . 3 Operators and known functions . 4 Notations . 4
Double-diﬀerential Measurements of Mesonless Charged-current Muon Neutrino Interactions on Argon with Final-State Protons using the MicroBooNE Detector

4 Event selection 6 4.1 CC inclusive preselection . 6 4.2 Containment volume . 11 4.3 CC0πNp selection . 11 4.4 Choice of phase-space limits . 11 4.5 Overall selection performance . 15
Chapter 1 Erdös-Rényi Random Graphs

In this chapter we will introduce and study the random graph model introduced by Erdös and Rényi in the late 1950’s. This example has been extensively studied and a very nice account of many of the results can be found in the classic book of Bollobás (2001), so here we will give a brief account of the main results on the emergence of a giant component, in order to prepare for the analysis of more complicated examples. In contrast to other treatments, we mainly rely on methods from probability and stochastic processes rather than combinatorics. To define the model, we begin with the set of vertices V = {1, 2, . n}. For 1 ≤ x < y ≤ n let ηx,y be independent = 1 with probability p and 0 otherwise. Let ηy,x = ηx,y. If ηx,y = 1 there is an edge from x to y. Here, we will be primarily concerned with situation p = λ/n and in particular with showing that when λ < 1 all of the components are small, with the largest O(log n), while for λ > 1 there is a giant component with ∼ g(λ)n vertices. The intuition behind this result is that a site has a Binomial(n − 1, λ/n) number of neighbors, which has mean ≈ λ. Suppose that we start with I0 = 1, and for t ≥ 1 let It be the set of vertices not in ∪t−1 s=0Is that are connected to some site in It−1. Then when t is not too large the number of points in It, Zt = |It|, is approximately a branching process in which each individual in generation t has an average of λ children. If λ < 1 the branching process dies out quickly and all components are small. When λ > 1, the branching process survives with probability g(λ), and all sites with surviving branching processes combine to make the giant component.
Renormalization of quantum field theory on curved space-times, a causal approach

Le sujet de la these est la construction d'une theorie perturbative des champs quantiques en interaction sur un espace-temps courbe, suivant un point de vue concu par Stueckelberg et Bogoliubov et developpe par Epstein-Glaser sur l'espace de Minkowski plat. En 2000 un progres important fut realise par Brunetti et Fredenhagen qui reussirent a etendre la theorie d'Epstein-Glaser en exploitant le point de vue developpe par Radzikowski pour definir les etats quantiques sur un espace-temps courbe en terme d'ensembles de front d'onde. Ces resultats furent ulterieurement generalises par Fredenhagen, Brunetti, Hollands, Wald, Rejzner, etc. Aux theories de Yang-Mills et de la gravitation. Cependant, meme pour des theories sans invariance de jauge, de nombreux details mathematiques sont restes inexplores et parfois sans verification. Dans cette these, on construit d'une facon totalement rigoureuse cette theorie dans le cas des champs sans invariance de jauge. Dans mon travail, j' ai revisite completement cette theorie, resolvant au passage plusieurs questions laissees en suspens, incorporant de nombreux resultats nouveaux autour de ce programme et, le cas echeant, apportant des details beaucoup plus precis sur les contre-termes dans le processus de renormalisation, une comprehension plus approfondie des ambiguites et une description geometrique des ensembles de front d'onde. L'ensemble de la these utilise un large eventail de techniques mathematiques : de la geometrie differentielle et pseudo riemannienne, des techniques d'analyse micro-locale et de geometrie symplectique pour les fronts d'onde, de l'analyse fonctionnelle, des resultats fins de la theorie des distributions,