Miracle-dz/UniFAR-FTUs huggingface dataset:
Cardioprotective Effects of Grapefruit IntegroPectin Extracted via Hydrodynamic Cavitation from By-Products of Citrus Fruits Industry: Role of Mitochondrial Potassium Channels

Citrus flavonoids are well-known for their beneficial effects at the cardiovascular and cardio-metabolic level, but often the encouraging in vitro results are not confirmed by in vivo approaches; in addition, the clinical trials are also inconsistent. Their limited bioavailability can be, at least in part, the reason for these discrepancies. Therefore, many efforts have been made towards the improvement of their bioavailability. Hydrodynamic cavitation methods were successfully applied to the extraction of byproducts of the Citrus fruits industry, showing high process yields and affording stable phytocomplexes, known as IntegroPectin, endowed with great amounts of bioactive compounds and high water solubility. The cardioprotective effects of grapefruit IntegroPectin were evaluated by an ex vivo ischemia/reperfusion protocol. Further pharmacological characterization was carried out to assess the involvement of mitochondrial potassium channels. Grapefruit IntegroPectin, where naringin represented 98% of the flavonoids, showed anti-ischemic cardioprotective activity, which was better than pure naringenin (the bioactive aglycone of naringin). On cardiac-isolated mitochondria, this extract confirmed that naringenin/naringin were involved in the activation of mitochondrial potassium channels. The hydrodynamic cavitation-based extraction confirmed a valuable opportunity for the exploitation of Citrus fruits waste, with the end product presenting high levels of Citrus flavonoids and improved bioaccessibility that enhances its nutraceutical and economic value.
Detectionof Major Depressive Disorder Based on a Combination of Voice Features: An Exploratory Approach

In general, it is common knowledge that people’s feelings are reflected in their voice and facial expressions. This research work focuses on developing techniques for diagnosing depression based on acoustic properties of the voice. In this study, we developed a composite index of vocal acoustic properties that can be used for depression detection. Voice recordings were collected from patients undergoing outpatient treatment for major depressive disorder at a hospital or clinic following a physician’s diagnosis. Numerous features were extracted from the collected audio data using openSMILE software. Furthermore, qualitatively similar features were combined using principal component analysis. The resulting components were incorporated as parameters in a logistic regression based classifier, which achieved a diagnostic accuracy of ~90% on the training set and ~80% on the test set. Lastly, the proposed metric could serve as a new measure for evaluation of major depressive disorder.
Altered composition of the oral microbiome in integrin beta 6-deficient mouse

ABSTRACT In periodontal disease (PD), bacterial biofilms suppress β6 integrin expression transforming growth factor-β1 signaling, resulting in gingival inflammation and bone loss. β6 integrin-null (Itgb6−/− ) mice develop spontaneous PD. The aim of this study was to unravel potential differences in oral microbiome in wild-type (WT) and Itgb6−/− FVB mice. Mouse oral microbiome was analyzed from 3- and 6-month-old WT and Itgb6−/− . The periodontal inflammation and spontaneous bone loss were present in 3-month-old and advanced in 6-month-old Itgb6−/− mice. The observed amplicon sequence variants (ASVs) of alpha diversity showed close similarity in 3-month-old and 6-month-old Itgb6−/− mice. Chao1 and ACE methods revealed that the microbiome in Itgb6−/− mice showed less diversity compared to the WT. UniFrac Principal Coordinate analyses (PCoA) showed a clear spatial segregation and clustering between Itgb6−/− and WT mice in general, and between 3-month- and 6-month-old WT mice. Weighted PCoA showed the tight clustering and distinct separation of individual mouse samples within Itgb6−/− and WT. The most abundant microbial classes varied between the sample groups. However, the genus Aggregatibacter significantly increased in the 6-month-old Itgb6−/− mice. β6 integrin-deficient mice develop periodontal inflammation that may relate to dysbiosis in the microbiome that further promotes the disease process.
An improved volumetric LBM boundary approach and its extension for sliding mesh simulation

The lattice Boltzmann method (LBM) has been emerging as a promising alternative CFD approach for complex fluid flows. With LBM, no-slip/free-slip wall boundary conditions are implemented via straightforward particle bounce-back/specular reflections on a solid surface, thus enable the use of Cartesian grid for accurate boundary representation. For curved boundary that is commonly encountered with complex geometry, available point-wise based LBM extrapolation/interpolation boundary schemes can not guarantee the exact hydrodynamic flux conditions. To address this fundamental issue, a volumetric LBM boundary scheme was proposed in 1998, which ensures an exact treatment of hydrodynamic fluxes on solid surface and establishes a generic framework for realizing hydrodynamic boundary conditions on curved surface. This dissertation presents the development of an improved volumetric LBM boundary scheme. The basic idea is when reflecting (scattering) back the fluid particles from solid boundary, particles should be distributed in the affected volume according to local flow information rather than uniformly as in the original volumetric LBM boundary formulation. To realize this, a scattering correction procedure is formulated and added to the originally proposed volumetric LBM boundary scheme framework. In particular, the procedure redistributes the surface scattered particles based on local velocity variation. As a result, it reduces the solution dependence on actual boundary location/orientation with respect to the computational grid, demonstrates an improved order of accuracy for flow solutions with arbitrarily located boundary. Accuracy of this approach has been demonstrated on typical flow benchmark problems that involve curved boundaries. In the second part of this dissertation, the proposed volumetric LBM boundary scheme is extended to sliding-mesh interface condition for flow simulation involving rotating geometries. A volumetric LBM sliding-mesh interface scheme couples the flow solutions on both sides of sliding interface, and conserves the mass and momentum flux across it. Accuracy of this scheme is demonstrated by performing a LBM-sliding mesh simulation of flow past a rotating propeller.
Genome-wide identification, phylogeny and expression analyses of group III WRKY genes in cotton (Gossypium hirsutum)

Abstract Cotton (Gossypium hirsutum) is an important economic crop, so it is of great significance to analyze its molecular mechanisms of resistance to Verticillium Wilt. The WRKY gene family encodes transcription factors (TFs) involved in plant resistance to biotic and abiotic stress. Here, we identified 17 group III WRKY genes in cotton based on the cotton genome project. The phylogenetic relationship and evolutionary of WRKY Group III TFs in Arabidopsis thaliana and G. hirsutum showed that all the WRKY Group III TFs were divided into two clades. Overall, Group III WRKYs with similar motif patterns showed a tendency to cluster into the same group in the phylogenetic tree. Elements related to jasmonic acid (JA) and salicylic acid (SA) regulation were identified in the promoter region of most WRKY Group III genes. The expression levels of five Group III genes were up-regulated more than two-fold and three genes were down-regulated after Verticillium dahliae Kleb. infection. Moreover, three group III GhWRKY genes with JA or SA regulatory element in the promoter region could be significantly induced by JA or SA, respectively. Subcellular localization and transcriptional activation analysis in yeast showed that Cot_14615 protein localized to the nucleus of mesophyll cells in Nicotiana tabacum and had transcription activation function. Our data on cotton group III WRKY genes can serve as a basis for further studies into their potential function in cotton resistant to Verticillium Wilt.
Corn Snakes Show Consistent Sarcomere Length Ranges Across Muscle Groups and Ontogeny

Abstract The force-generating capacity of muscle depends upon many factors including the actin-myosin filament overlap due to the relative length of the sarcomere. Consequently, the force output of a muscle may vary throughout its range of motion, and the body posture allowing maximum force generation may differ even in otherwise similar species. We hypothesized that corn snakes would show an ontogenetic shift in sarcomere length range from being centered on the plateau of the length-tension curve in small individuals to being on the descending limb in adults. Sarcomere lengths across the plateau would be advantageous for locomotion, while the descending limb would be advantageous for constriction due to the increase in force as the coil tightens around the prey. To test this hypothesis, we collected sarcomere lengths from freshly euthanized corn snakes, preserving segments in straight and maximally curved postures, and quantifying sarcomere length via light microscopy. We dissected 7 muscles (spinalis, semispinalis, multifidus, longissimus dorsi, iliocostalis (dorsal and ventral), and levator costae) in an ontogenetic series of corn snakes (mass = 80–335 g) at multiple regions along the body (anterior, middle, and posterior). Our data shows all of the muscles analyzed are on the descending limb of the length-tension curve at rest across all masses, regions, and muscles analyzed, with muscles shortening onto or past the plateau when flexed. While these results are consistent with being advantageous for constriction at all sizes, there could also be unknown benefits of this sarcomere arrangement for locomotion or striking.
Triterpenoid Saponins from Washnut (Sapindus mukorossi Gaertn.)—A Source of Natural Surfactants and Other Active Components

Sapindus mukorossi Gaertn. , also called the washnut, is a tropical tree of the Sapindaceae family. The plant owes its name to its cleaning and washing properties used by the local population as a natural detergent. The most important ingredients of the plant are triterpenoid saponins contained in many parts of the plant, inducing fruits, galls, or roots. The tree also contains other valuable, biologically active compounds that are obtained by extraction methods. Raw or purified extract and isolated saponins are valuable plant products that can be used in the food, pharmaceutical, cosmetic, and chemical industries. This review includes the most important biological and surfactant properties of extracts and isolated saponins obtained from various parts of the plant.
Turkish Attributions to Marriage: the Role of Family of Origin Functioning and Perceived Parenting

ABSTRACT Aim: The aim of this study is to determine the role of family of origin functioning and perceived parenting styles in explaining the meanings that individuals attribute to the concept of heterosexual marriage in a Turkish sample. Method: One hundred seventy-five Turkish individuals reached by online-sampling were included in the study. In the data analysis, multiple linear regression analysis was conducted. Fındıngs: Analysis results showed that while the predictivity of affective responsiveness, communication, behavioral control, and roles dimensions of the family of origin functioning were found significant, it was seen that emotionally depriving mother/father, normative mother/father, exploitative/abusive father, belittling/criticizing father, and conditional/achievement father perceptions shape the concept of marriage. Conclusıon: This study showed that the elements related to the family of origin system and perceived parenting styles play a role in the formation of meanings that individuals attribute to heterosexual marriage.
A Survey on Evaluating the Quality of Autonomic Internet of Things Applications

The rapid evolution of the Internet of Things (IoT) facilitates the development of IoT applications in domains such as manufacturing, smart cities, retail, agriculture, etc. Such IoT applications collect data, analyze, and extract insightful information to enable decision-making and actuation. There is an unprecedented growth of IoT applications that automate decision-making and actuation without requiring human intervention, which we term autonomic IoT applications. The increasing scale of such applications necessitates holistic measurement and evaluation of application quality. Existing literature has evaluated quality from an end-user perspective, which may be unsuitable when dealing with the complexity of modern IoT applications, especially when they are autonomic. In this paper, we refer to IoT application quality as the aggregate quantitative value of various IoT quality metrics measured at each stage of the autonomic IoT application life cycle. We present an in-depth survey of current state-of-the-art techniques and approaches for evaluating quality of IoT applications. In particular, we survey various definitions to identify the factors that contribute to understanding and evaluating quality in IoT. Furthermore, we present open issues and identify future research directions towards realizing fine-grained quality evaluation of IoT applications. We envision that the identified research directions will, in turn, enable real-time diagnostics of IoT applications and make them quality-aware. This survey can serve as the basis for designing and developing modern, resilient quality-aware autonomic IoT applications.
Non-equilibrium neutrino emissivities and opacities of neutron star matter

The neutrino emissivity of neutron star matter out of the β equilibrium is calculated. Such condition can prevail in a neutron star matter undergoing rapid compression. The formulae for the neutrino emissivity from direct and modified β processes are expressed in terms of the difference between the chemical potentials for the plasma composed of neutrons, protons, and electrons, δμ = μ n - μ p - μ e
CtIP Regulates Mitotic Spindle Assembly by Modulating the TPX2-Aurora A Signaling Axis

CtBP-interacting protein (CtIP) plays a critical role in controlling the homologous recombination-mediated DNA double-stranded break (DSB) repair pathway through DNA end resection, and recent studies suggest that it also plays a role in mitosis. However, the mechanism by which CtIP contributes to mitosis regulation remains elusive. Here, we show that depletion of CtIP leads to a delay in anaphase progression resulting in misaligned chromosomes, an aberrant number of centrosomes, and defects in chromosome segregation. Additionally, we demonstrate that CtIP binds and colocalizes with Targeting protein for Xklp2 (TPX2) during mitosis to regulate the recruitment of TPX2 to the spindle poles. Furthermore, depletion of CtIP resulted in both a lower concentration of Aurora A, its downstream target, and very low microtubule intensity at the spindle poles, suggesting an important role for the CtIP-TPX2-Auroa A complex in microtubule dynamics at the centrosomal spindles. Our findings reveal a novel function of CtIP in regulating spindle dynamics through interactions with TPX2 and indicate that CtIP is involved in the proper execution of the mitotic program, where deregulation may lead to chromosomal instability.
Very promising hole in Bell's theorem

Nakhmanson 1/7 The J. S. Bell's theorem is based on the following assertion: if Pa is a probability of result a measured on the particle 1 in the point A having a condition (e.g. angle of analyzer) α , and Pb is a probability of result b measured on the particle 2 in the distant point B having a condition β , then β has no influence on the Pa , and vice versa. Here Bell and others saw the indispensable requirement of local realism and "separability". Mathematically it can be written as
Effect Of Exercise on Muscle Mass, Fat Mass, Bone Mass, Muscular Strength and Physical Performance in Community Dwelling Older Adults: Systematic Review and Meta-Analysis

The demographic transition makes it necessary to establish new recommendations about the components that are most affected by aging, such as: muscle mass, fat mass, bone mass, muscle strength, and physical performance. Exercise has been identified as a factor that improves those conditions. The aim of this review is to synthetize and analyze the results of exercise interventions on muscle mass, fat mass, bone mass, strength and physical performance in community dwelling older adults (OA). A systematic search was carried out in eleven databases, using validated terms as “aged”, “exercise” and others. For the meta-analysis, we differentiated by type of exercise and outcome. Twenty-nine randomized clinical trials were obtained for the review and 24 clinical trials for meta-analysis. This study identified an increase of 1.0 kg (95% Confidence Interval [CI] 0.3 -1.7) in total muscle mass (TMM) and 0.4 kg (95%CI 0.0,0.7) in appendicular muscle mass (AMM); a decrease of -3.7 kg (95% CI -5.8, -1.5) in total fat mass and -3.7% (95%CI -5.8, -1.5) in fat percentage after the resistance exercise intervention by 2-3 times per week. A -3.0% (95%CI -4.6, -1.3) decrease was observed in fat percentage after the aerobic exercise intervention. The quality of the evidence was ranked from high to very low; the risk of bias most common was performance bias and other bias. This study suggests that resistance exercise is the intervention that shows a positive effect on muscle fat mass, and bone mass. More research is needed for other exercise interventions.
Influence of Parenting on Maladaptive Schemas and Emotion Regulation in Adolescents Presenting With Self-Injurious Behavior in a Tertiary Care Hospital of North India

Introduction: Parenting is a key factor in development of cognitive and emotional patterns of viewing self, others, and the world. The present study aimed to explore the influence of parenting on early maladaptive schemas (EMS) and emotion regulation in individuals presenting with self-injurious behavior. Method: A total of 32 adolescents with self-injurious behavior aged 15 to 18 years participated in this cross-sectional exploratory study. Measures used were Parental Handling Questionnaire, Difficulties in Emotion Regulation Scale, and Young Schema Questionnaire—Short Form. Results: The results indicate a significant negative correlation of parental care with lack of emotional clarity (r = −0.403, P < .05) with schema of self-punitiveness (r = −0.179, P < .05) and a significant positive correlation with emotional inhibition (r = 0.423, P < .05) and schema of admiration seeking (r = 0.364, P < .05). Parental control was found to be significantly positively correlated with schemas of pessimism (r = 0.350, P < .05) and significantly negatively correlated with admiration seeking (r = 0.477, P < .01). Parenting was also found to be a significant predictor for emotion regulation and EMS (P < .05). Conclusion: Parenting has a significant influence on emotional regulation and EMS. Findings have a bearing on future research and targeted interventions in clinical care settings.
Pediatric Residency Training amid the COVID-19 Pandemic: Exploring the Impact of Supervision and Clinical Practice Guidelines on Clinical and Financial Outcomes

Objective This study is aimed at calculating the magnitude of the effect of clinical practice guidelines (CPG) and supervision in inhibiting the negative impact of the COVID-19 pandemic on clinical and financial outcomes of non-COVID-19 inpatient care by pediatric residents in academic medical center (AMC) hospitals during the COVID-19 pandemic. Methods The cohort retrospective study was conducted. This study collected patient data from pediatric residency programs. A research cohort consisted of non-COVID-19 pediatric patients at Dr. Soetomo General Academic Hospital. This study compared the subgroup of patients treated during the pandemic with those treated before the pandemic. The results were analyzed using SPSS 26.0 and Smart-PLS. Results There was a 41.4% decrease in pediatric inpatients during the pandemic with an increased severity level and complexity level, a reduction of 7.46% availability of supervisors, an increase of 0.4% in readmission < 30 days, an increase of 0.31% in-hospital mortality, an increase the total costs of care, and a decrease of insurance claim profit. CPG did not moderate the effect of the COVID-19 pandemic on the clinical outcomes (β = −0.006, P = 0.083) but moderated the financial outcomes (β = −0.022, P = 0.000), by reducing the total cost of care and increasing insurance claim profit. Supervision moderated the effect of the COVID-19 pandemic on the clinical outcomes (β = 0.040, P = 0.000) by increasing aLOS and on the financial outcomes (β = −0.031, P = 0.000) by reducing the total cost of care and increasing insurance claim profit. This study model had a 24.0% variance of explanatory power for clinical outcomes and 49.0% for financial outcomes. This study's structural model effectively predicted clinical outcomes (Q2 = 0.238) and financial outcomes (Q2 = 0.413). Conclusion Direct supervision inhibited the negative impact of the COVID-19 pandemic on both clinical and financial outcomes of non-COVID-19 inpatient care by pediatric residents, while CPG only inhibited the negative impact on financial outcomes. Implication of This Study. In a disaster, the availability of CPG and direct supervision makes AMC hospitals able to inhibit the negative impact of disasters on clinical and financial outcomes.
Spectral curves and the generalised theta divisor.

Let X be a smooth, irreducible, projective curve over an algebraically closed field of characteristic 0 and let g = gx ̂ 2 be its genus. We show in this paper that a generic vector b ndle on X of rank n and any fixed degree can be obtained s the direct image of a line b ndle on an n-sheeted (ramified) covering of X. From this we deduce results concerning linear Systems on the moduli space of vector bundles of rank n and degree 0.