Miracle-dz/UniFAR-FTUs huggingface dataset:
Fetal Homocysteine and Birth Weight Are Affected by Maternal Homocysteine before Conception and throughout Pregnancy

Background: Increased homocysteine has been associated with pregnancy complications. Methods: We investigated prospectively the effect of maternal homocysteine on normal pregnancy outcome. The study included 93 women and their offspring; 39 of the women took folic acid during the second and/or third trimesters of pregnancy. We measured homocysteine at preconception; at weeks 8, 20, and 32 of pregnancy; during labor; and in the fetal cord; we also recorded birth weight. Results: Mean (SE) maternal total homocysteine (tHcy) increased between 32 weeks of pregnancy and labor [7.98 (1.39) (cid:1) mol/L in unsupplemented women and 6.26 (1.47) (cid:1) mol/L in supplemented women; P < 0.0001 for both]. Fetal tHcy was lower than maternal tHcy [6.39 (1.44) (cid:1) mol/L in unsupplemented pregnancies ( P < 0.0001), and 5.18 (1.39) (cid:1) mol/L in supplemented pregnancies ( P < 0.05)]. Maternal tHcy was correlated from preconception throughout pregnancy (8 weeks, r (cid:2) 0.708; 20 weeks, r (cid:2) 0.637; 32 weeks, r (cid:2) 0.537; labor, r (cid:2) 0.502; P < 0.0001 for all time points) and with fetal tHcy [preconception, r (cid:2) 0.255 ( P < 0.05); 8 weeks, r (cid:2) 0.321 ( P < 0.01); 20 weeks, r (cid:2) 0.469; 32 weeks, r (cid:2) 0.550; labor, r (cid:2)
Different availabilities of reduced nitrogen: Effects on oxidative stress in chicory plants

: The aim of this work was to study the induction of the synthesis of ROS-scavenging molecules and the evolution of enzymatic activities such as ascorbate peroxidase (APX) and polyphenoloxidase (PPO) as a function of different availabilities of reduced nitrogen. Chicory seedlings were grown in nutritive solution for 35 days in controlled conditions. On the 14 th day, one third of the plants was transferred into a nutritive solution containing (NH 4 ) 2 SO 4 60 mM, one third was transferred into a medium containing Urea 60 mM, and the remaining was let grow in the nutrition solution, as a control. Three samplings of leaves were performed, respectively after 21, 28 and 35 days of growth. The urea and ammonium sulphate-treated samples showed higher ascorbic acid and polyphenol contents than the control, together with a lower anthocyanins content. APX showed the highest activity in the urea-treated samples, while the highest PPO activity was to refer to samples treated with ammonium sulphate. The variations in organic components suggest an effect of the supply of reduced nitrogen on the cell redox potential, confirming the importance of fertilization for obtaining high amounts of antioxidant molecules.
Electronic structure and chemical bonding in KTiOPO4

The cluster discrete variational method is used to calculate the electronic structure of fragments of the crystal lattice of KTiOPO4. The influence of various structural elements on the energy band formation and the composition of one-electron states has been studied. The transformation of charge density distribution and of chemical bonding in different cluster models has been considered.
Design and evaluation of an educational tool for understanding functionality in flight simulators

The use of simulation in aircraft development and pilot training is essential as it saves time and money. The ARINC 610C standard describes simulator functionality, and is developed to streamline the use of flight simulators. However, the text based standard lacks overview and function descriptions are hard to understand for the simulator developers, who are the main users. In this report, an educational software tool is conceptualised to increase usability of ARINC 610C. The usability goals and requirements were established through multiple interviews and two observation studies. Consequently, six concepts were produced, and evaluated in a workshop with domain experts. Properties from the evaluated concepts were combined in order to form one concluding concept. A prototype was finally developed and evaluated in usability tests with the potential user group. The results from the heuristic evaluation, the usability tests, and a mean system usability score of 79.5 suggests that the prototyped system, developed for visualising ARINC 610C, is a viable solution.
An exploratory study on psychosocial variables of people participating in Zoophilic Blogs/Websites

Objectives; This study aimed to investigate sociodemographic and psychometric features of people participating in zoophilic blogs/websites. Methods: One-hundred six subjects provided information through an online questionnaire. Measures of drug misuse, sexual impulsivity, and depression symptoms were included. Results: Childhood sexual abuse, earlier onset of sexual interest in animals, preference for male animals, and higher levels of sexual impulsivity were associated with higher zoophilic interest. Conclusion: The strength of sexual interest may be associated with negative events in childhood, early onset of anomalous sexual interest, and higher sexual impulsiveness, characteristics commonly seen among paraphilic persons.
Biodegradation of Microplastics in Drinking Water, A review

Microplastics are emerging as an ever-increasing threat to the environment and are becoming an issue of concern among researchers. Microplastics are often detected in the environment, the risks they pose are debated and largely unknown. One important challenge in determining the threats of microplastics to humans and the environment is the heterogeneity of the physical and chemical properties, the nature and concentration of the particles and the difficulty in identifying standardized detection systems. Microplastics can reach drinking water supplies from surface run-off, degraded plastic waste, atmospheric deposition, and wastewater effluent. The effluent from wastewater treatment plants is one of the most important factors behind the contamination of microplastics. Microplastics in drinking water supplies have recently been detected. This article presents an analysis and review of available literature on the effects of microplastics on freshwater, agriculture, and ecosystems, as well as emerging treatment methods with an emphasis on microplastic biodegradation. The article will display a model used to measure the export of microplastic waste from land to sea. Finally, the policy and regulation and the way the Sustainable Development Goals will reduce microplastic emissions will be addressed.
for the rates of compact binary coalescences by ground-based gravitational-wave

We present an up-to-date, comprehensive summary of the rates for all types of compact binary coalescence sources detectable by the Initial and Advanced versions of the ground-based gravitational-wave detectors LIGO and Virgo. Astrophysical estimates for compact-binary coalescence rates depend on a number of assumptions and unknown model parameters, and are still uncertain. The most conﬁdent among these estimates are the rate predictions for coalescing binary neutron stars which are based on extrapolations from observed binary pulsars in our Galaxy. These yield a likely coalescence rate of 100 Myr − 1 per Milky Way Equivalent Galaxy (MWEG), although the rate could plausibly range from 1 Myr − 1 MWEG − 1 to 1000 Myr − 1 MWEG − 1 [1]. We convert coalescence rates into detection rates based on data from the LIGO S5 and Virgo VSR2 science runs and projected sensitivities for our Advanced detectors. Using the detector sensitivities derived from these data, we ﬁnd a likely detection rate of 0 . 02 per year for Initial LIGO-Virgo interferometers, with a plausible range between 2 × 10 − 4 and 0 . 2 per year. The likely binary neutron-star detection rate for the Advanced LIGO-Virgo network increases to 40 events per year, with a range between 0 . 4 and 400 per year.
CORPORATE ENTREPRENEURSHIP AND INCREASING COMPETITIVENESS WITH SPECIFIC REFERENCE OF ENTERPRISES IN MACEDONIA

: Corporate entrepreneurship is new modern management concept in which essence is management with changing environment and constant innovation. Application of the concept of corporative entrepreneurship enables enterprises successful market appearance and achieving competitive advantage. This concept is focused on preparation of enterprises for achievement of innovative capability in different forms. In the applied part of this paper will be performed standard statistical tests such as ANOVA, frequency analysis, will be tested reliability of the questions (variables) in the questionnaire. Basic contribution in this paper is about expansion of the literature in this area and measurement of the intensity of investment as an indicator for the presence of corporative entrepreneurship and increase in the competitive advantage. On the basis of the results will be proposed directions for overcoming of the known state and improving of the working quality of the enterprises through the corporative entrepreneurship concept.
An account of transforms on \bar {{\cal A}/{\cal G}}

In this article we summarize and describe the recently found transforms for theories of connections modulo gauge transformations associated with compact gauge groups. Specifically, we put into a coherent picture the so-called loop transform, the inverse loop transform, the coherent state transform and finally the Wick rotation transform which is the appropriate transform that incorporates the correct reality conditions of quantum gravity when formulated as a dynamical theory of connections while preserving the simple algebraic form of the Hamiltonian constraint.
Source and Distribution of Polycyclic Aromatic Hydrocarbon (PAHs) in Surface Sediment from Chalong Bay, Phuket,

This study aimed to investigate the spatial distribution and apportionment of potential sources of the 16 US-EPA priority PAHs in surface sediments of Chalong Bay, Phuket, Thailand. A total 28 of sediment samples were collected from areas with high maritime activity in Chalong Bay, subjected to conventional high recovery Soxhlet extraction, purified with SiO 2 column chromatography, and quantified by Gas Chromatography-Mass Spectrometry (GC/MS). Total concentration of PAHs (Σ 16 PAHs) ranged from 31.15 to 1696 ng g −1 dry weight, with an average of 198.2 ± 318.5 ng g −1 dry weight. Binary diagnostic ratios plots were used to distinguish between petrogenic and pyrogenic sources. Most of the PAHs in sediments originated from pyrolytic sources. PCA analysis explained 82.3 % of the variance by only 4 predominant components. The first principal component (PC1) (26.7 %) was mainly contributed to urban street runoff and municipal wastewater discharge. PC2 (25.8 %) represented vehicular combustion sources, PC3 (19.1 %) was attributed to petrogenic sources, and PC4 (10.7 %) was only associated with Naphthalene. The sources of PAHs distributed around Chalong Bay included oil spills, combustion of fossil fuels by shipping, urban street runoff, and municipal wastewater discharge. Each type of sources affected different locations along shores of Chalong Bay.
SEISMIC CHARACTERIZATION OF A SHALLOW GAS-HYDRATE-BEARING RESERVOIR ON THE NORTH SLOPE OF ALASKA

Occurrence of gas hydrates on the North Slope of Alaska has been recognized for over three decades. Large-scale well-log studies over the entire North Slope, including detailed temperature profiling in the shallow subsurface, suggest widespread gas-hydrate occurrence, which is facilitated by the depressed geothermal gradient and thick permafrost (Collett et al., 1988). The Milne Point Unit (MPU) is one of several large, active oil fields on the North Slope of Alaska (Figure 1) characterized by a thick, near-surface gas-hydrate-stability zone (HSZ) as documented by many well-log-inferred gas-hydrate occurrences. These factors, along with moderate well coverage, a modern 3-D seismic survey and complex structure make MPU an ideal location for characterizing shallow, onshore gas-hydrate occurrence and distribution.
Soil Organic Matter Dynamics Along Gradients in Temperature and Land Use on the Island of

We studied soil organic matter (SOM) dynamics in allophanic soils (Udands) along independent gradients of temperature (altitude) and land use (forest-pasture) on the island of Hawaii. Using an integrated '3C signal derived from land conversion along with measurements of soil respiration and soil carbon, we separated rapid, intermediate, and very slow turnover SOM pools, and estimated turnover times for the large intermediate pool. These estimates were compared to independent estimates using either bomb-derived soil 14C or the Century soil organic matter model. All calculations based on a three-pool SOM structure yield rates of turnover that are 3 times slower than those produced by a single pool model. Accordingly, analyses of potential feedbacks between changes in climate, atmospheric C02, and soil carbon should incorporate the heterogeneous nature of soil organic matter. We estimate that roughly three-quarters of the carbon in the top 20 cm of these soils has turnover times less than 30 yr. Turnover times for intermediate SOM double with a 10'C change in mean annual temperature, suggesting that recalcitrant pools of SOM may be as sensitive to changes in temperature as the smaller labile pools.
CMAR_A_310529 5091..5100

1Department of Urology, East Hospital, Ji’an Hospital, Jiangxi, 343000, People’s Republic of China; 2Department of Urology, East Hospital, Tongji University School of Medicine, Shanghai, 200123, People’s Republic of China Introduction: Long noncoding RNAs (lncRANs) as suppressive or oncogenic genes have been substantiated in prostate cancer (PCa). In the current study, the role and molecular mechanism of lncRNA AATBC in the progression of PCa was evaluated. Methods: LncRNA AATBC and miR-1245b-5p expression were evaluated using RT-qPCR. CCK-8, colony-formation, apoptosis and transwell assay were used to analyze the in vitro role. The xenograft model was used to explore the in vivo role. Bioinformatics analysis and a dual luciferase assay, RIP and RNA pull down were used to confirm the interaction between lncRNA AATBC and 1245b-5p, as well as 1245b-5p and CASK. Results: Firstly, we certified that the expression of AATBC was augmented in PCa, and knockdown of AATBC could significantly inhibit the growth of PCa in vitro and in vivo. Mechanistically, our results manifested that AATBC could directly bind to miR-1245b-5p. In addition, miR-1245b-5p played cancer-suppressive role in PCa cells. Moreover, CASK was attested as the target of miR-1245b-5p, and CASK was demonstrated to exert as oncogene in the progression of PCa. Finally, rescue assays illustrated that miR-1245b-5p downregulation or CASK restoration could greatly resist the restrained effects of AATBC knockdown on PCa progression. Conclusion: AATBC could accelerate the progression of PCa through regulating miR1245b-5p/CASK axis, which provided a potential therapeutic target for PCa treatment.
OP-AOBP170013 1..8

Invasive herbivores can dramatically impact the nitrogen (N) economy of native hosts. In deciduous species, most N is stored in stem tissues, while in evergreen conifer species N is stored in needles, making them potentially more vulnerable to herbivory. In eastern forests of the USA, the long-lived, foundational conifer eastern hemlock (Tsuga canadensis) is under the threat of extirpation by the invasive hemlock woolly adelgid (HWA: Adelges tsugae). We assessed the impact of HWA infestation on the patterns of seasonal foliar N availability in hemlock planted in a deciduous forest understory. Over the course of a year, we sampled needles and twigs and measured N, carbon (C), C:N ratio, and total protein concentrations. Tissue sampling events were timed to coincide with key lifehistory transitions for HWA to determine the association between HWA development and feeding with these foliar nutrients. In uninfested trees, needle and twig N concentrations fluctuated across seasons, indicating the potential importance of N storage and remobilization for the N economy of eastern hemlock. Although N levels in HWAinfested trees also cycled annually, the degree to which N concentrations fluctuated seasonally in tissues was significantly affected by HWA feeding. These fluctuations exceeded N levels observed in control trees and coincided with HWA feeding. HWA feeding generally increased N concentrations but did not affect protein levels, suggesting that changes in N do not occur via adelgid-induced protein breakdown. Herbivore-induced mobilization of N to feeding sites and its rapid depletion may be a significant contributor to eastern hemlock mortality in US forests.
Identiﬁcation of the Hypoxia-Inducible Factor 1 (cid:3) -Responsive HGTD-P Gene as a Mediator in the Mitochondrial Apoptotic Pathway

Hypoxia-inducible factor 1 (cid:1) (HIF-1 (cid:1) ) controls the cellular responses to hypoxia, activating transcription of a range of genes involved in adaptive processes such as increasing glycolysis and promoting angiogenesis. However, paradoxically, HIF-1 (cid:1) also participates in hypoxic cell death. Several gene products, such as BNip3, RTP801, and Noxa, were identiﬁed as HIF-1 (cid:1) -responsive proapoptotic proteins, but the complicated hypoxic cell death pathways could not be completely explained by the few known genes. Moreover, molecules linking the proapoptotic signals of HIF-1 (cid:1) directly to mitochondrial permeability transition are missing. In this work, we report the identiﬁcation of an HIF-1 (cid:1) -responsive proapoptotic molecule, HGTD-P. Its expression was directly regulated by HIF-1 (cid:1) through a hypoxia-responsive element on the HGTD-P promoter region. When overex-pressed, HGTD-P was localized to mitochondria and facilitated apoptotic cell death via typical mitochondrial apoptotic cascades, including permeability transition, cytochrome c release, and caspase 9 activation. In the process of permeability transition induction, the death-inducing domain of HGTD-P physically interacted with the voltage-dependent anion channel. In addition, suppression of HGTD-P expression by small interfering RNA or antisense oligonucleotides protected against hypoxic cell death. Taken together, our data indicate that HGTD-P is a new HIF-1 (cid:1) -responsive proapoptotic molecule that activates mitochondrial apoptotic cascades. The tester cDNA was hybridized with excess driver cDNA digested with RsaI (the ﬁrst hybridization), and subtracted single-stranded cDNA was converted to double-stranded DNA by a second hybridization with another adaptor-linked ﬁrst hy- bridization. The subtracted cDNA was ampliﬁed by PCR with the primer set located in the adaptors and inserted into the TA vector (Clontech). Cell culture, hypoxic conditions, and cell death analysis. PC-3 prostatic cancer cells were cultured in RPMI medium containing 10% fetal bovine serum under 5% CO 2 . Primary cortical neuronal cells were prepared from a postnatal day 1 BALB/c mouse as described (1). On day 4 of culture, cytosine arabinoside was added at a ﬁnal concentration of 10 (cid:4) M in order to prevent nonneuronal cell proliferation, and neurons were used on day 7. For hypoxic conditions, cells in medium gassed with 95% N 2 –5% CO 2 were transferred to a hypoxic chamber equipped with an air lock and continuously gassed with 0.5% O 2 –5% CO 2 , with the balance being nitrogen. Apoptotic cells exhibiting altered DNA morphology
MONTE-CARLO METHODS IN GLOBAL ILLUMINATION

This book discusses Monte Carlo algorithms and their application to solve the global illumination rendering problem of computer graphics. Mathematically, photo-realistic rendering is equivalent to the solution of an integral equation that can be successfully attacked by Monte Carlo integration techniques. The book first discusses the theory of light-surface interaction and the equations that describe materials and the transfer of the illumination. We examine Monte Carlo and quasi-Monte Carlo approaches, which can be used to solve these equations. A considerable space is devoted to variance reduction techniques, including importance sampling, correlated sampling, the Metropolis method, weighted importance sampling, etc. Then the book presents random walk algorithms, like path tracing, light tracing, bi-directional path tracing, photon mapping, instant radiosity, Metropolis light transport, etc. Stochastic iterative techniques are also surveyed. Finally, implementation details are shortly addressed taking the example of path tracing.
Two-dimensional numerical simulation of the resistive reconnection layer

In this paper a two-dimensional, time dependent, numerical simulation of a reconnection current layer in incompressible resistive magnetohydrodynamics with uniform resistivity in the limit of very large Lundquist numbers is presented. Realistic boundary conditions derived consistently from the outside magnetic field are used, and the effect of the back pressure from flow into the separatrix region is also taken into account. It is found that within a few Alfven times the system evolves from an arbitrary initial state to a steady state consistent with the Sweet–Parker model, even if the initial state is Petschek-like.
PRACTICE OF EPIDEMIOLOGY META-ANALYSIS Breastfeeding in Infancy and Blood Pressure in Later Life: Systematic Review and Meta-Analysis

The influence of breastfeeding on blood pressure in later life is uncertain. The authors conducted a systematic review of published studies from which estimates of a mean difference (standard error) in blood pressure between breastfed and bottle-fed subjects could be derived. They searched MEDLINE and Excerpta Medica (EMBASE) bibliographic databases, which was supplemented by manual searches of reference lists. Fifteen studies (17 observations) including 17,503 subjects were summarized. Systolic blood pressure was lower in breastfed compared with bottle-fed infants (pooled difference: –1.4 mmHg, 95% confidence interval (CI): –2.2, –0.6), but evidence of heterogeneity between study estimates was evident ( χ 216 = 42.0, p < 0.001). A lesser effect of breastfeeding on systolic blood pressure was observed in larger ( n ≥ 1,000) studies ( – 0.6 mmHg, 95% CI: –1.2, 0.02) compared with smaller ( n < 1,000) studies ( – 2.3 mmHg, 95% CI: –3.7, –0.9) ( p for difference in pooled estimates = 0.02). A small reduction in diastolic blood pressure was associated with breastfeeding (pooled difference: – 0.5 mmHg, 95% CI: –0.9, –0.04), which was independent of study size. If causal, the small reduction in blood pressure associated with breastfeeding could confer important benefits on cardiovascular health at a population level. Understanding the mechanism underlying this association may provide insights into pathways
Research Online Research Online The Wiki: an environment to revolutionise employees' interaction with The Wiki: an environment to revolutionise employees' interaction with corporate knowledge corporate knowledge

Abstract Some corporations have adopted a Wiki on their Intranets for employees to collectively store, edit and access workrelated material such as reports, best-practice features, and documents. As such collaborative software moves from the social to the corporate arena, it is bound to challenge management authority, engaging the knowledge worker in a more participatory knowledge capability and environment. This paper explores the implication that this revolution has for the interaction of corporate users with technology that will lead to a profound change in organisational culture. ABSTRACT Some corporations have adopted a Wiki on their Intranets for employees to collectively store, edit and access workrelated material such as reports, best-practice features, and documents. As such collaborative software moves from the social to the corporate arena, it is bound to challenge management authority, engaging the knowledge worker in a more participatory knowledge capability and environment. This paper explores the implication that this revolution has for the interaction of corporate users with technology that will lead to a profound change in organisational culture.