Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlation of Serum Insulin-Like Growth Factor-1 and Hand Wrist Radiographs as Skeletal Maturity Indicators: an Ex-Vivo Study

Introduction: Conventional Hand and Wrist radiographs, have certain drawbacks of exposing orthodontic patients to unnecessary radiation hazards and subjectivity to errors. Serum insulin-like growth factor 1 (IGF-1) levels have been reported to increase until the pubertal peak in literature. The present study aims to assess the relationship between serum IGF-1 and skeletal maturity indicators Materials and Methods: Lateral cephalograms of 60 patients were assigned SMI stage according to Fishman’s classification system. The serum IGF-1 levels of the patients were also evaluated. Correlation between the serum IGF-1 levels, age of the patient, and their SMI stage was analyzed. Results: Pearson's coefficient of correlation revealed a non-significant weak positive correlation (p=0.69; >0.05) between age and IGF-1 levels, and a non-significant weak negative correlation (p =0.52; >0.05) between SMI stages and IGF-1 levels. Results of the ANOVA test indicated that there was no significant difference between mean IGF-1 levels across the different age groups and eleven SMI groups. However, there was a significant difference noted in the mean IGF-1 levels and the restructured SMI categories and groups. Conclusion: The moderate correlation between age and serum IGF-1 fluctuations during puberty underscores the hormone's pivotal role in adolescent growth. This positions serum IGF-1 as a potentially specific and reliable marker for assessing mandibular growth modifications, offering a radiation-free alternative to conventional radiographic methods
Stratospheric ozone vertical distribution from far-infrared balloon spectra and statistical analysis of the errors

A daytime and nighttime vertical distribution of ozone is retrieved from far-infrared emission spectra recorded by a balloon-borne Fourier transform spectrometer with 0.0033-cm−1 resolution. The accuracy achieved is approximately 11% in the 27- to 39-km altitude range. The global-fit analysis performed on several different spectral intervals and on several different limb-scanning sequences allows a statistical evaluation of individual error components due to frequency-dependent and time-dependent uncertainty sources, as well as to spectral noise. The statistical evaluation of the error component due to the latter source is in good agreement with the estimate given by the nonlinear least squares fitting algorithm. The possible causes of the observed 9.5% difference between day and night column densities in the 29- to 34-km altitude range are discussed. Our altitude profiles are compared with the results of previous analyses of the same data set and with the results obtained using other instruments during the same campaign of measurements.
Política Industrial 4.0: Reflexões Sobre os Casos do Brasil e da Argentina

Historicamente, a política industrial tem sido objeto de constantes discussões e controvérsias, tanto no contexto teórico quanto na esfera de política econômica de países desenvolvidos e em desenvolvimento. Nesse sentido, o principal foco deste artigo consiste em abordar, de forma exploratória e contextual, a questão da política industrial e sua relação com a indústria 4.0, principalmente no contexto latino-americano. Especificamente são discutidos aspectos relacionados ao papel do Estado e sua capacidade como orquestrador da política industrial, e todo o contexto institucional que envolve o processo inovativo e a introdução da política industrial 4.0 no Brasil e na Argentina. As principais conclusões da pesquisa apontam para uma desindustrialização acelerada de ambos os países nos últimos anos e para uma política para indústria 4.0 em estágios iniciais ou de preparação socioeconômica do sistema, assim como uma política de caráter passivo pela definição de seus objetivos e pelo horizonte pautado por ações que não envolvem, no longo prazo, grandes projetos de desenvolvimento tecnológico ou substituição de importações.
Salud mental en adultos atendidos en un centro de referencia en Chiapas, México, 2012-2018

Objetivo: Determinar la frecuencia de trastornos mentales y su relación con variables demográficas, antecedentes familiares y consumo de alcohol y drogas en adultos atendidos en la Unidad de Atención a la Salud Mental San Agustín, de Tuxtla Gutiérrez, Chiapas, México, durante el período 2012-2018. Material y métodos: Estudio de diseño transversal que incluyó el registro de 4612 adultos, de entre 18 y 60 años de edad, vistos en el servicio de consulta externa de la unidad de atención referida durante el período 2012-2018. Resultados: El 50 % de los probandos fueron mujeres; y el 60 % tenían entre 18 y 39 años. Los trastornos más frecuentes encontrados fueron esquizofrenia (31,2 %), trastornos del estado de ánimo (24,1 %) y trastornos de ansiedad (21,9 %). Las variables de edad, sexo, antecedentes familiares, consumo de alcohol y drogas ilícitas se asociaron definidamente con los trastornos más frecuentes, destacando el hecho de que los trastornos del ánimo presentaron mayor prevalencia entre los jóvenes y las mujeres. Conclusión: Los hallazgos respecto a los trastornos más prevalentes, así como algunos de los factores asociados a los mismos en este estudio, son consistentes con los encontrados en otros países de la región. Esto puede constituirse en un componente importante de estrategias que mejoren perspectivas y procedimientos en la atención a la población chiapaneca con problemas de salud mental.
Secondary Metabolites from the Nematode-Trapping Fungus Dactylellina haptotyla YMF1.03409

As a representative nematode-trapping fungus, Dactylellina haptotyla can capture and kill nematodes by producing traps, known as adhesive knobs. In this paper, the strain of D. haptotyla YMF1.03409 was studied by means of medium screening, fermentation, and purification and identification of crude extracts. Eighteen compounds were obtained from D. haptotyla YMF1.03409, including two new metabolites, nosporins C (1) and D (2). The known metabolites were identified to be 3-chloro-4-methoxybenzaldehyde (3), 3-chloro-4-methoxybenzoic acid (4), 2-chloro-1-methoxy-4-(methoxymethyl)benzene (5), 3-hydroxy-3-methyloxindole (6), nicotinic acid (7), succinic acid (8), 3,4-dihydroxybutanoic acid (9), 5′-O-methyladenosine (10), uridine (11), 2′-deoxyuridine (12), thymidine (13), 3-(phenylmethyl)-2,5-morpholinedione (14), methyl-β-D-glucopyranoside (15), 1,2-benzenedicarboxylic acid bis(2-methyl heptyl) ester (16), β-sitosterol (17), and 3β,6α-diol-stigmastane (18). The bioactive assay showed that these compounds had no obvious nematicidal activity against the nematodes Meloidogyne incognita and Panagrellus redivivus.
Phytochemical Analysis and Biological Activities
of Reamuria vermiculata Leaves,
Stem and Roots Extracts

In the present study, the phenolic compounds, mineral composition, of ethanol and water extracts from different Reamuria vermiculata parts (leaves, stems and roots) was investigated. The antioxidant and antimicrobial proprieties were screened using experimental and computational approaches. Results have reported that the fraction aqueous of roots had a higher amount of polyphenol, flavonoid and tanins than stems and leaves (1153.29 mg GAE/g, 308.16 mg CE/g, 31.84 mg CE/g DW) respectively. Also, the same extract has significant scavenging activity to decrease free radicals especially for DPPH (IC50 = 0.04 mg/mL), ABTS radicals (IC50 = 0.002 mg/mL) and β-carotene (IC50 = 0.06 mg/mL). In addition, the minerals K, Mg, Na, and Ca were detected as considerably high quantities in leaves. Moreover, the ethanol extract of roots exhibited an antimicrobial property against bacterial strains Listeria monocytogenes with MIC =0.0781 mg/ml, staphylococcus aureus and Bacillus subtilis with MIC = 0.3125 mg/ml. The overall results provided some valuable information that spices have powerful antioxidant and antimicrobial potentials, which could be an interesting material for industrial purposes.
Embolia cutis Medicamentosa (Nicolau syndrome): case series

Introduction Embolia cutis medicamentosa or Nicolau syndrome is a rare drug reaction associated with the administration of various injectable medications. The pathogenesis of the disease is unknown, though intra and periarterial injection of the drug is a possible cause. The aim of this study was to describe and analyze the clinical characteristics of Nicolau syndrome in patients examined in daily dermatological practice. Methods We performed a retrospective chart review, between January 2011 and December 2020, in patients diagnosed with Nicolau syndrome, from the cases of a private dermatology medical office in Târgu Mureș, Romania. Results During the 10-year period, 7 patients were diagnosed with Nicolau syndrome. Of these, 4 (57%) patients were males and 3 (43%) were females, The male to female ratio was 1.33. The median age was 64 (interquartile range, IQR, 62–71), with the youngest patient being diagnosed at age 61 and the oldest at age 74. Regarding the drugs classes that caused Nicolau syndrome, these were intravenous antibiotics in 57%, and non-steroidal anti-inflammatory drugs in 43% of cases. Conclusion All patients healed in a period of 6 to 8 weeks. No complications occurred. In conclusion, Nicolau syndrome is a rare side effect of injectable drug administration.
Tissue Distributions and Toxic Effects of Hexavalent Chromium in Laboratory-Exposed Periwinkle (Littorina littorea Linnaeus)

Simple Summary The increased application of chromium compounds in several fields has resulted in elevated levels of toxic hexavalent chromium (Cr6+) in the aquatic environment, thus creating the potential for bioaccumulation of Cr6+ in the tissues as well as eliciting various toxic effects in organisms. The present study investigated the effects of Cr6+ exposure on the tissue distribution, proximate composition, and histopathology of an aquatic mollusk, periwinkle (Littorina littorea). The animals were exposed to sublethal concentrations of Cr6+ (0.42, 0.84, and 4.2 mg/L) for 30 days. Exposure to Cr6+ resulted in changes in the proximate composition and histological architecture of L. littorea. There was a low potential for bioaccumulation of Cr6+ in the tissue of L. littorea. Thus, its consumption did not pose any serious health risks to humans. Abstract The increased use of hexavalent chromium (Cr6+) in various industrial applications has contributed to its elevated levels in the environment, especially the aquatic environment. Thus, there is the potential for accumulation of Cr6+ in the tissues of aquatic organisms and consequent toxic effects. The toxic effects of Cr6+ in aquatic organisms have been widely reported; however, little is known about the patterns of tissue accumulation of Cr6+ and its toxicity in aquatic mollusks. Thus, the present study investigated the effects of Cr6+ exposure on the tissue distribution, proximate composition, and histopathology of an aquatic mollusk, periwinkle (Littorina littorea). The animals were exposed to sublethal concentrations of Cr6+ (0.42, 0.84, and 4.2 mg/L) for 30 days, after which the condition index, tissue accumulation, proximate composition, and histopathological effects were determined. The control animals were maintained in a medium that did not contain Cr6+ (0 mg/L). The condition index did not differ significantly among the groups. The levels of Cr6+ in the tissues differed significantly among the different tissue types while there was no significant effect of the exposure concentration, except in the foot tissue. The proximate parameters (protein, carbohydrates, lipid, crude fiber, and moisture contents) differed significantly among the groups. The protein contents of the exposed animals were significantly lower than those of the control animals and the histological architecture of the major organs was altered in the chromium-exposed animals. The findings from this study indicate a low potential of L. littorea to bioaccumulate Cr6+ in its tissues at the low exposure concentrations tested in this study; as such, its consumption may not pose any serious health risks to humans. However, changes in the proximate composition and histological architecture of the exposed L. littorea show that Cr6+ is potentially toxic to periwinkles.
Immunotherapy in patients with brain metastasis: advances and challenges for the treatment and the application of circulating biomarkers

The central nervous system (CNS) is one of the most frequent metastatic sites of various cancers, including lung cancer, breast cancer and melanoma. The development of brain metastases requires a specific therapeutic approach and is associated with high mortality and morbidity in cancer patients. Advances in precision medicine and the introduction in recent years of new drugs, such as immunotherapy, have made it possible to improve the prognosis of these patients by improving survival and quality of life. New diagnostic techniques such as liquid biopsy allow real-time monitoring of tumor evolution, providing molecular information on prognostic and predictive biomarkers of response to treatment in blood or other fluids. In this review, we perform an exhaustive update of the clinical trials that demonstrate the utility of immunotherapy in patients with brain metastases and the potential of circulating biomarkers to improving the results of efficacy and toxicity in this subgroup of patients.
Deletion of Salmonella enterica serovar Typhi tolC reduces bacterial adhesion and invasion toward host cells

Background S. Typhi is a Gram-negative bacterium that causes typhoid fever in humans. Its virulence depends on the TolC outer membrane pump, which expels toxic compounds and antibiotics. However, the role of TolC in the host cell adhesion and invasion by S. Typhi is unclear. Objective We aimed to investigate how deleting the tolC affects the adhesion and invasion of HT-29 epithelial and THP-1 macrophage cells by S. Typhi in vitro. Methods We compared the adhesion and invasion rates of the wild-type and the tolC mutant strains of S. Typhi using in vitro adhesion and invasion assays. We also measured the expression levels of SPI-1 genes (invF, sipA, sipC, and sipD) using quantitative PCR. Results We found that the tolC mutant showed a significant reduction in adhesion and invasion compared to the wild-type strain in both cell types. We also observed that the expression of SPI-1 genes was downregulated in the tolC mutant. Discussion Our results suggest that TolC modulates the expression of SPI-1 genes and facilitates the adhesion and invasion of host cells by S. Typhi. Our study provides new insights into the molecular mechanisms of S. Typhi pathogenesis and antibiotic resistance. However, our study is limited by the use of in vitro models and does not reflect the complex interactions between S. Typhi and host cells in vivo.
Guided Direct Time-of-Flight Lidar Using Stereo Cameras for Enhanced Laser Power Efficiency

Self-driving vehicles demand efficient and reliable depth-sensing technologies. Lidar, with its capability for long-distance, high-precision measurement, is a crucial component in this pursuit. However, conventional mechanical scanning implementations suffer from reliability, cost, and frame rate limitations. Solid-state lidar solutions have emerged as a promising alternative, but the vast amount of photon data processed and stored using conventional direct time-of-flight (dToF) prevents long-distance sensing unless power-intensive partial histogram approaches are used. In this paper, we introduce a groundbreaking ‘guided’ dToF approach, harnessing external guidance from other onboard sensors to narrow down the depth search space for a power and data-efficient solution. This approach centers around a dToF sensor in which the exposed time window of independent pixels can be dynamically adjusted. We utilize a 64-by-32 macropixel dToF sensor and a pair of vision cameras to provide the guiding depth estimates. Our demonstrator captures a dynamic outdoor scene at 3 fps with distances up to 75 m. Compared to a conventional full histogram approach, on-chip data is reduced by over twenty times, while the total laser cycles in each frame are reduced by at least six times compared to any partial histogram approach. The capability of guided dToF to mitigate multipath reflections is also demonstrated. For self-driving vehicles where a wealth of sensor data is already available, guided dToF opens new possibilities for efficient solid-state lidar.
Çalışma Yaşamında Bilinçli Farkındalığın Örgütsel Sağlığa Etkisi Üzerine Bir Araştırma

Mindfulness; It is stated that it is theorized simply as “receptive attention and awareness towards current events and experiences”. This study was carried out to determine the effect of mindfulness on organizational health. Data were collected from 620 actively working white and blue-collar volunteers in Istanbul. The sample was reached through the convenience sampling method. Analyzes were carried out on 615 valid surveys. According to the correlation analysis, a positive, highly significant relationship was found between Mindfulness and Organizational Health (r= 782, p<0.01). As a result of regression analysis; The power of mindfulness to explain organizational health was found to be 61.1%. When the interaction on the basis of sub-dimensions was examined, it was determined that mindfulness had an impact on the sub-dimensions of organizational health. When the analyzes to test the explanatory power and effect are examined; When the β value is examined, it is seen that the independent variable has an effect. When the findings were examined, it was determined that the effect power of the mindfulness dimension was 78.2%. As a result of the regression analyses, it was determined that there was a significant relationship and interaction between the dependent variable and the independent variable. In addition, when this interaction was examined on the basis of sub-dimensions, it was determined that the sub-dimension with the most impact was the general level. As a result of the research, it was determined that as mindfulness increases, healthy perception and attribution of organizations also increases. In fact, it has been determined that employees with high mindfulness consider their organizations to be healthy at a general level. It appears that results are consistent with the literature. When their influence power is examined, it is seen that there are different factors that are likely to affect organizational health. It is recommended that the effect of the personality factor, which may affect the variables of the study, be examined in future studies. Keywords: Organizational Behavior, Mindfulness, Organizational Health.
The origins and relationships of lower invertebrates

The lower invertebrates - from sponges to annelids - have been investigated for over a century, but there are fundamental problems that are only now coming under scrutiny. This book gives fresh impetus to the subject area, presenting a broad synthesis of current trends and pointing out areas likely to develop rapidly over the next few years. It emphasizes particularly active research areas, such as ultrastructural (TEM, SEM) work and phylogenetic methods - especially cladistics.
Isolating advective signatures in temperature logs

Geothermics as a discipline of Geophysics deals with the description of the thermal regime, its variation in time, and the associated processes. These processes can be quantified by their characteristic thermal signature observed in temperature records. Heat transfer in the Earth’s crust occurs primarily by thermal diffusion. On the other hand, heat advection due to groundwater flow in general is a more efficient transport mechanism. Therefore, the subsurface temperature field can be a sensitive indicator of even small flow rates. The challenge is to isolate the desired thermal signature from interfering signatures. This is achieved by eliminating the thermal signatures of all other processes and factors from the temperature data which may be caused by heterogeneity of thermal rock properties, heat generation, and transient variations of the ground surface temperature. Otherwise, these signatures may be misinterpreted leading to false conclusions. This work focuses on quantifying groundwater flow (Darcy flow) and eliminating technical perturbations from temperature logs. Both main topics complement each other because the analysis of groundwater flow on temperature data will benefit from an improved database. In turn, the flow analysis provides useful information to constrain results from classic approaches, for instance interpretation of hydraulic data. The factors and processes which eventually disturb a flow analysis are introduced. The importance of disturbing effects depends on both magnitude and shape of the superposed thermal signatures. Subsurface Darcy flow can be identified by its characteristic thermal signature. Here, a simple geothermal technique is proposed for quantifying regional strata-bound flow based on a detailed analysis of borehole temperatures. Depending on the spatial
Acoustic waves in finely layered media

The propagation of acoustic waves through a periodically stratified medium is examined theoretically and experimentally with the purpose of determining how the velocity of the composite material depends on the periodicity structure, the material properties, and frequency. A numerical simulation of a recently published experiment shows that the propagator method gives results in close agreement with the experimental observations. Using eigenvalue analysis, an expression for the sound velocity and scattering loss is calculated for all frequencies. The results show that, for frequencies lower than a certain critical (or limiting) frequency, the propagation is dispersive and no loss occurs. Above this frequency the waves are evanescent and suffer scattering loss at each interface. An expression for the limiting frequency is derived which takes into account the contrast in impedance between the two media.
Do community entrepreneurial development shape the sustainability of tourist villages?

This study looks at the role of community entrepreneurial development in mediating the linkages between geographical conditions, local wisdom, and traditional culture on the sustainability of tourism villages. In this study, this hypothesis was evaluated quantitatively. Respondents filled out a questionnaire as a research instrument. Village officials, the Tourist Awareness Group (Pokdarwis), and the community in Cikolelet Tourism Village, Banten Province, participated in this research. 140 individuals were selected for this study using purposive sampling, and the data were analyzed using a structural equation model (SEM). According to the conclusions of this study, geographical conditions, local wisdom, and traditional culture have a beneficial and statistically significant influence on community entrepreneurial development but do not directly affect the sustainability of tourism villages. Community entrepreneurial development influences the sustainability of tourist villages. Furthermore, community entrepreneurial development mediates the relationship between geographical conditions, local wisdom, and traditional culture on the sustainability of tourist villages. These findings recommend that tourism stakeholder cooperation between village officials, the Tourist Awareness Group, and the community must collaborate in the sustainability of the tourist village. This paper offers novelty by investigating community entrepreneurial development variables as mediators of the influence of geographical conditions, local wisdom, and traditional culture on the sustainability of tourist villages with exploratory quantitative analysis. In contrast, previous research only used explorative qualitative analysis, at least in the tourism sector, from an Indonesian perspective.