Miracle-dz/UniFAR-FTUs huggingface dataset:
NASA Research in Composite Structure Damage Tolerance and Composite Applications In the Oil Industry

Many factors influence the successful introduction of composite materials into structural applications including a recognized need for improvement over existing technology, material property advantages, innovative structural concepts, advanced design capability, and cost. Motivation to use composite structures in the aerospace industry is dri ven primarily by weight saving which provide enhanced performance benefits. Weight saving is also an important factor for special applications proposed for the oil industry, especially deepwater developments. Other assets of composites are also important including fatigue and corrosion resistance. Consideration of reliability and safety is especially important in both industries. Composites exhibit unique failure modes compared to metals and it is important to understanding the reductions in strength caused by damage. Early pioneering work at NASA on composites established that compression; and especially the reduction in compression strength following damage, placed severe limits on the design allowables for highly loaded components such as aircraft wi ng and fuselage structure. Research by NASA established important design constraints for composite structures which were subsequently integrated into guidelines for the design of composites for commercial aircraft. Early research concentrated on establis hing the limitations imposed by the effect of damage on compression strength and to develop innovative ways to improve performance. Approaches studied included: damage tolerant resins and innovative design concepts such as soft -skin stiffened panels, hybrid composites, bonded and bolted stiffeners, and laminate stitching. In addition, test methods were developed to access improvement advancements including: open hole compression, open hole tension, and compression after impact. Optimization design methods were exercised to develop minimum-weight composite comparisons with aluminum designs including consideration of the limitations imposed by damage. Many of the foundation principles in composites developed at NASA have been applied to applications in the oil industry. The paper discusses the pioneering work in damage tolerance conducted at NASA and describes how the technology developed has been applied in the development of composites technology for applications in the oil industry such as spoolable high pressure composite pipe, composite risers, carbon fiber tendons and synthetic fiber mooring ropes. The paper is intended as a memorial to Dr. James H. Starnes, Jr. with whom the author worked closely at NASA in the area of composites mechanics and design for 15 years.
A sinewave fitting procedure for characterizing data acquisition channels in the presence of time base distortion and time jitter

A method is proposed to characterize the nonlinear behaviour of a data acquisition channel using a sinewave fitting procedure. Three error sources are considered: the nonlinear (dynamic) behaviour of the data acquisition channel (amplifiers, sample-and-hold, analog-digital-convertor), the time base distortion and the time jitter. Also the time base distortion and the jitter variance are estimated from the same experiment.
An Approximate Algorithm for Shakedown on Gear Contact

A model of gear contact has been established based on Hertz theory. Local coordinates are constructed on different meshing points because curvature of gear profile is not constant and then distributions of residual stresses and strains are given. Upper and lower bounds for the shakedown limits have been obtained. An approximate algorithm based on a stress invariant hypothesis and a stress/strain relaxation procedure is developed to solve residual stresses and strains accumulation in elastic-plastic stress analysis of gear contact. The steady-state residual stresses of gear under repeat meshing are calculated. The results are useful information for the strength design of gear.
Experiment to visualize equipotential lines in a re al complex circuitry

An experiment is proposed to observe equipotential lines in a complex circuitry using a specific probe. The map of equipotential lines is built sweeping the probe across the circuitry. To validate this approach, an experimental ground plane has been analyzed. Measured results have been faced to a rigorous electromagnetic simulation made with a commercial software based on Maxwell's equations. The equipotential lines observed on the ground plane are similar to those calculated numerically.
Technologies for superconducting nanowire single-photon detector array system

We present the development of key technologies for realization of superconducting nanowire single photon detector array system, which enables high counting rates, and allow spatial and pseudo photon number resolution. Toward the realization of practical large-scale SSPD array system, primary issue is how to avoid heat flow into cryocooler system. One of the challenging tasks is the development of their readout electronics. In the conventional readout technique used for single pixel devices, the number of high-frequency coaxial cables increases proportionally with the number of arrays. This causes a significant increase in the heat load from room temperature, which makes the implementation of the SSPD arrays in a compact refrigerator difficult. To overcome this problem, we proposed applying readout electronics with superconducting single-flux-quantum (SFQ) logic circuitsWe show the implementation and successful operation of four pixels SSPD array connected to SFQ readout electronics with parallel bias scheme in a 0.1W GM cryocooler system.
RhoJ facilitates angiogenesis in glioblastoma via JNK/VEGFR2 mediated activation of PAK and ERK signaling pathways

Glioblastoma (GBM) is a highly vascularized malignant tumor that depends on new blood vessel formation. Small molecules targeting the angiogenic process may be an effective anti-GBM therapeutic strategy. We previously demonstrated that RhoJ promoted the progression and invasion of GBM. RhoJ has also been shown to be expressed in endothelial cells and plays an important role in regulating endothelial cell migration and tumor angiogenesis. Therefore, we aimed to evaluate the role and mechanism of actions of RhoJ in GBM angiogenesis. We analyzed the expression of RhoJ in different grade gliomas and investigated its role in GBM angiogenesis in vivo and in vitro. Furtherly, RNA sequencing (RNA-seq), Western blotting and immunofluorescence were performed to identify the molecular mechanism of RhoJ in regulating endothelial cell behavior and GBM angiogenesis. Here, we found that silencing RhoJ resulted in inhibition of HUVEC cell migration and blood vessel formation. Overexpression of RhoJ promoted the expression of CD31, EpCAM and moesin, suggesting RhoJ facilitated angiogenesis and the malignant progression of GBM. RNA-seq data showed that VEGF/TNF signaling pathway positively regulated RhoJ. The expression levels of RhoJ was upregulated with the stimulation of VEGF, and reduced by the treatment of JNK inhibitor SP600125. It was also found that the activity of PAK-BRAF-ERK was down-regulated upon RhoJ and JNK knockdown. In conclusion, these results suggested that RhoJ plays an essential role in regulating GBM angiogenesis through the JNK/VEGFR2-PAK-ERK signaling pathway and there might exist a VEGF-JNK/ERK-VEGF circuitry. Thus, RhoJ may be a candidate therapeutic target for anti-angiogenesis treatment in GBM.
DESIGN AND IMPLEMENTATION OF LASER POWDER BED FUSION ADDITIVE MANUFACTURING TESTBED CONTROL SOFTWARE

The National Institute of Standards and Technology developed a facility titled the Additive Manufacturing Metrology Testbed to advance the research in laser powder bed fusion (LPBF) processes. The testbed adopted an open control architecture which allows full access to all key process parameters. Although LPBF control is a very important topic, very little literature can be found on how this is implemented. This paper reviews the testbed control software design and implementation. Scan path planning, galvo motion control, and laser power control are detailed with select highlights. Comparison with commercial machine control software is made, and recent experiments utilizing the advanced features of the testbed control software are also discussed.
Dual mode cross-slotted filters realized with superconducting films

A planar superconducting single stage dual mode filter has been investigated and tested. The basic element of the device is a square patch resonator diagonally crossed by unequal slots to provide both a size reduction and a simple way to couple the two degenerate modes. The effect of further cuts, realized on the conductor surface, is also investigated with respect to the power handling capability and miniaturization requirements. Two different filter topologies operating in C band with 1% fractional bandwidth have been designed and fabricated using Nb and YBa2Cu3O7 films grown on 10×10×0.5 mm3 LaAlO3 (100) substrates. Device response is studied performing power and intermodulation measurements. Third order products start to appear above the noise floor (−120 dBm) at input power Pin≈−20 dBm, whereas thermomagnetic breakdown is observed above 20 dBm.
Preparing Advanced Clinicians and Practitioners: A Model for Mentorship in Occupational Therapy Practice

Mentoring is essential at all stages of a professional career. However, little has been written about the effectiveness of programs for practicing clinicians. This study was designed to address the need for evidence about the effectiveness of formal mentorship programs by describing the impact of the STAR mentorship program on a group of clinicians specializing in sensory integration and processing challenges. This study utilized an exploratory, retrospective, survey research design. Course evaluations were examined from 240 subjects following participation in a one-week, small group mentorship training program. Qualitative methods were adapted for use in this study. Sixteen codes, with operational definitions, were developed to analyze the surveys. Ninety-six percent indicated that the program met or exceeded their expectations; only 12.5% had a negative comment. Impact on psychosocial function was reflected by 22% of the participants. Comments related to impact on career function were indicated by 45% of the participants. Ninety-four percent provided positive comments about the program structure, and 74% responded with positive comments regarding content of the program. Positive outcomes were associated with this one mentorship program, suggesting a need for more in-person, structured mentored learning experiences. Mentorship is recommended as a method to address the growing need within the profession to support career development, build knowledge, skill and attitudes, and aspirations/commitment as well as enhance professionalism/professional development.
NDS_A_337135 145..154

1Section of Clinical Genetics and Metabolism, Department of Pediatrics, University of Colorado, Aurora, CO, USA; 2Met Ed Co, Boulder, CO, USA; 3Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA; 4University Medical Center HamburgEppendorf, Hamburg, Germany; 5Department of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Cardiology of the Developmental Age, Pomeranian Medical University, Szczecin, Poland; 6Inherited Metabolic Diseases Clinic, Children’s Hospital Colorado, Aurora, CO, USA; 7Nutrition and Metabolism, NOVA Medical School | Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisboa, 1169-056, Portugal; 8CINTESIS Center for Health Technology and Services Research, Porto, Portugal; 9Reference Centre of Inherited Metabolic Diseases, Centro Hospitalar Universitário de Lisboa Central, Lisboa, 1169-045, Portugal; 10Hospital Universitario Ramon y Cajal, Madrid, Spain Abstract: Phenylketonuria (PKU) is one of the most common inherited metabolic disorders, and historically has required affected individuals to follow a severely protein-restricted diet with medical food for life. A novel enzyme substitution therapy, pegvaliase, allows many adults with PKU on therapy to have a reduction in blood phenylalanine (Phe) while on an unrestricted diet. However, there is limited information on optimal nutrition management of individuals with PKU on pegvaliase therapy. This manuscript summarizes a virtual European meeting focused on nutrition management of individuals on pegvaliase therapy, including three case studies and a patient perspective that together provide clinical insights into the real-world management of individuals with PKU on pegvaliase.
PGPM_A_341723 1679..1687

1Biochemistry and Molecular Biology Department, National Hepatology & Tropical Medicine Research Institute, Cairo, Egypt; 2Gastroenterology and Tropical Medicine Department, Faculty of Medicine, Minia University, Minia, Egypt; 3Department of Dermatology, Andrology and STDs, Faculty of Medicine, Minia University, Minia, Egypt; 4Clinical Pharmacology Department, Faculty of Medicine, Benha University, Benha, Egypt; 5Biochemistry Department, Faculty of Medicine, October 6 University, 6th of October City, Egypt; 6Clinical Nutrition Department, National Nutrition Institute, Cairo, Egypt; 7Clinical and Chemical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt; 8Faculty of Pharmacy, Fellow of Clinical Pharmacology, Cairo University Hospitals, Giza, Egypt; 9Pharmacy Practice and Clinical Pharmacy Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Egypt; 10Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt; 11Department of Dermatology, Andrology, Sexual Medicine and STDs, Faculty of Medicine, Helwan University, Cairo, Egypt Background: Acne vulgaris (AV) is a chronic inflammatory disease that affects the pilosebaceous unit. Leptin (LEP) gene polymorphisms is associated with higher risk of multiple disorders. Insulin-like growth factor-1 (IGF-1) exerts comedogenic effect by stimulating the sebaceous glands. Isotretinoin is an effective oral therapy for AV with many side effects including hyperlipidemia and increased serum levels of liver enzymes. Purpose: To evaluate the impact of LEP gene rs7799039 polymorphism in acne patients’ clinical response lipid profile and liver enzymes following 6 months oral isotretinoin therapy in Egyptian AV patients. Methods: One hundred eligible AV patients received 0.5 mg/kg oral isotretinoin for 6 months. Patients’ demographics and clinical data were obtained. Body mass index (BMI), lipid profile, liver enzymes and IGF-1 were measured at baseline and after 6 months of therapy. Genotyping was done for LEP gene rs 7799039. Results: Six month administration of oral isotretinoin in Egyptian AV patients is associated with significantly elevated aspartate transaminase (AST) in CC and AC genotypes (P<0.001). Significant alanine aminotransferase (ALT) elevation was observed in CC, AC and AA genotypes (P <0.001, 0.004, 0.002, respectively). Total cholesterol (TC), triglycerides (TG) and low density lipoprotein (LDL) were elevated significantly P<0.001) in the three genotypes. IGF-1 was decreased significantly in CC and AC genotypes (P<0.001). CC genotype is associated with highest response (P<0.001). Conclusion: LEP rs7799039 gene had an impact on the clinical response, lipid profile and liver enzymes in AV patients treated with oral isotretinoin. LEP rs7799039 CC genotype is predicted to be the treatment candidate for 6 month oral isotretinoin.
An Optimization Reconstruction Algorithm Based on Regularization and Backtracing

—In compressed sensing (CS), the traditional matching pursuit algorithms have a narrow adaptability to the sparsity and a higher time complexity. To expand the adaptability to sparsity and reduce the time complexity, a regularized-subspace pursuit (R-SP) algorithm is proposed. The regularization rule of the regularized orthogonal matching pursuit (ROMP) algorithm and the backtracing mechanism of the subspace pursuit (SP) algorithm are used to improve the accuracy of atom selection. The results of experiment show that in one-dimensional signal, the reconstruction probability of each algorithm is almost the same when the sparsity K is small. However, when the sparsity K increases, the R-SP algorithm has higher reconstruction probability and obvious advantages of reconstruction time. In two-dimensional images, the reconstruction performance of R-SP algorithm is slightly worse than ROMP algorithm. What’s more, the R-SP algorithm widens the range of sparsity K , shortens the reconstruction time and achieves the complementary advantages when compared with other algorithms.
Living with Incomprehension and Uncertainty

Introduction Omnipresence of non-comprehension and ignorance Nature of incomprehension Incomprehension versus Misunderstanding Incomprehension in personal experience Incomprehension in relation to governance Incomprehension and ignorance within systems of belief Incomprehensible constraints on comprehensive capacity Experiencing incomprehension personally Incomprehension in the face of information overload Incomprehensible inadequacy of collective response Being misunderstood and incomprehension of the other Re-cognition, epistemology and metaphysics Towards the systematic reframing of incomprehension through metaphor (Annex A) Towards the dynamic art of partial comprehension (Annex B) Conclusion References
Improving the N-version programming process through the evolution of a design paradigm

The application of the N-version programming (NVP) technique in a project that reused the revised specification of a real, automatic airplane landing problem. The study involved 40 students, who formed 15 independent programming teams to design, program, test, and evaluate the application. The impact of the paradigm on the software development process, the improvement of the resulting N-version software (NVS) product, the insight, experience, and learning in conducting this project, various testing procedures applied to the program versions, several quantitative measures of the resulting NVS product, and some comparisons with previous projects are discussed. The effectiveness of the revised NVP design paradigm in improving software reliability by providing fault tolerance is demonstrated. >
Development of domestic tourism in the context of a pandemic

Preserving the health of the population occupies a special place at the legislative level, in the socio-economic strategies for the development of regions and the country as a whole. The preservation of human health depends not only on one's own desire to preserve it, including the current state of the state and the development of the country's tourism industry. Recreation and recreation for modern people, who mainly live in cities and megacities characterized by a high level of pollution due to the intensity of economic activity, are of particular importance for maintaining health and life expectancy. An increase in people's life expectancy is considered at the state level as an important indicator of people's well-being, improving the level and quality of life. Russia has created unique conditions and opportunities for the development of domestic tourism, which, with reasonable organization, investments, including the creation of public-private partnerships, and improving the efficiency of services provided, allow us to carry out our activities in the field of preserving and maintaining public health, increasing the duration and quality of life. Domestic Russian tourism can be considered as the basis for the socio-economic development of territories at any level, as well as as an industry whose contribution to the country's GDP can be significant.
Gender Was Associated with Depression but Not with Gastrointestinal Dysfunction in Patients with Parkinson's Disease

Objective To investigate the association between gender and gastrointestinal (GI) dysfunctions, as well as gender and other motor symptoms/nonmotor symptoms, in a sample of PD patients. Methods 186 patients with PD were recruited into this study and divided into male PD group (M-PD) and female PD group (FM-PD). Demographic and PD-related clinical information of the participants were collected by the same neurologist. PD patients were objectively assessed by a spectrum of rating scales of motor symptoms and nonmotor symptoms (including GI dysfunctions). The data were analyzed by SPSS 20 statistical software. Results Totally 95 cases (51.08%) were in the M-PD group and 91 cases (48.92%) in the FM-PD group. There were no significant differences in age, BMI, and lifestyles between the two groups (P > 0.05). Males had higher educational level (P = 0.002). Females were more likely to have early satiety and loss of appetite (P = 0.025, P = 0.001). There were no significant differences in LED disease duration, age of motor symptoms onset, types of motor symptoms onset, location of motor symptoms onset, and phenotype of motor symptoms between the two groups (P > 0.05). Females had significantly higher UPDRS-III and HAMD scores than males (P = 0.037, P = 0.034). There were no significant differences in PQSI, ESS, RLS, RBD, HAMA, HAMD, and MoCA scores between the two groups. Gender was associated with HAMD (OR = 0.682, P = 0.019). Conclusions Gender is a risk factor for depression, but not for GI dysfunctions in patients with PD.
Using Medial Surfaces to Produce Graded Voronoi Cell Infill Structures for 3D Printed Objects

Many methods of additive manufacturing rely on infill structures to decrease part mass and print time. However, standard infill patterns generally use a uniform density or require time-consuming analysis to generate a density field tailored to part geometry. We propose a Voronoi cell based infill structure which uses the medial surfaces of the object to locate thin regions and increase local material density. The Voronoi cell structure reduces transition points within the infill, producing a more even gradient in density, while the weighting scheme ensures that traditionally weaker portions of the model receive adequate internal support.
Microbiological and clinical effects of a Proanthocyanidin-enriched extract from Rumex acetosa in periodontally healthy carriers of Porphyromonas gingivalis

Rumex acetosa significantly inhibits the adhesion of Porphyromonas gingivalis (P.g.) to eukaryotic host cells in vitro. The objective of this randomized placebo-controlled pilot-trial was to analyze effects of a mouth rinse containing 0.8 % (w/w) of a quantified proanthocyanidin-enriched extract from Rumex acetosa (RA1) on microbiological, clinical, and cytological parameters in systemically healthy individuals without history of periodontitis, harboring P.g. intraorally. 35 subjects received a supragingival debridement (SD) followed by mouth rinsing (3 times daily) with either RA1 mouth rinse solution (test) or placebo (control) for 7 days as adjunct to routine oral hygiene. Supragingival biofilm samples were taken at screening visit, baseline (BL), 2, 4, 7 and 14 days after SD. P.g. and 11 other oral microorganisms were detected and quantified by rtPCR. Changes in the oral microbiota composition of one test and one control subject were assessed via high throughput 16S rRNS gene amplicon sequencing. Approximal Plaque Index (API) and the modified Sulcular Bleeding Index (SBI) were assessed at BL, 7- and 14-days following SD. Brush biopsies were taken at BL and 14 d following SD. Intergroup comparisons revealed no significant microbiological, cytological, and clinical differences at any timepoint. However, a significant reduction in SBI at day 14 (p=0.003) and API at day 7 (p=0.02) and day 14 (p=0.009) was found in the test group by intragroup comparison. No severe adverse events were observed. The results indicate that RA1 mouth rinse is safe but does not seem to inhibit colonization of P.g. or improve periodontal health following SD.