Miracle-dz/UniFAR-FTUs huggingface dataset:
Sensitivity analysis of experimentally determined grounding grid impulse characteristics

The paper presents an experimental determination of the grounding grid impulse characteristics procedure. The measuring circuit configuration and characteristics of the applied equipment are given. Some of the numerous experimental results for three grounding grid configurations are presented. The paper provides the analysis of the results obtained for various impulse current shapes, magnitudes and discharge points. The results shown are related to the cases without soil ionization around the grid elements.
TCM Main Drives Revamping of Pangang

To study how to do, if adapting a Adjustable-Speed AC Drive System to control the equipment, now which is been controlled by the Adjustable-Speed DC Drive. According the operating parameters that requested by the production line of the Cold Rolling Mill of Pangang, the paper proves a revamping project. The project includes the selection of motor, the calculation of the electrical capacity of motor, and the selection of speed-control mode. Also the paper analyses and put forward to the revamping project of related supporting facilities.
Manufacturing system design with optimal diagnosability

This paper addresses the quality issues of advanced manufacturing systems that require frequent reconfiguration to satisfy customers' demands. The approach embodies the diagnosability issues in the design of such systems so that monitoring and identification of the symptoms of the critical quality characteristics can be carried out effectively. A diagnosability matrix model is constructed to delineate the relationships between attributes of quality monitoring and fault diagnosis. Based on this matrix, the conditions of optimal diagnosability are established. Then, a systems approach which is based on axiomatic design theory is applied to achieve optimal design for diagnosability (DFD). An industrial case study demonstrating the application of the optimal DFD approach is described.
Capsaicin and TRPV1 Channels in the Cardiovascular System: The Role of Inflammation

Capsaicin is a potent agonist of the Transient Receptor Potential Vanilloid type 1 (TRPV1) channel and is a common component found in the fruits of the genus Capsicum plants, which have been known to humanity and consumed in food for approximately 7000–9000 years. The fruits of Capsicum plants, such as chili pepper, have been long recognized for their high nutritional value. Additionally, capsaicin itself has been proposed to exhibit vasodilatory, antimicrobial, anti-cancer, and antinociceptive properties. However, a growing body of evidence reveals a vasoconstrictory potential of capsaicin acting via the vascular TRPV1 channel and suggests that unnecessary high consumption of capsaicin may cause severe consequences, including vasospasm and myocardial infarction in people with underlying inflammatory conditions. This review focuses on vascular TRPV1 channels that are endogenously expressed in both vascular smooth muscle and endothelial cells and emphasizes the role of inflammation in sensitizing the TRPV1 channel to capsaicin activation. Tilting the balance between the beneficial vasodilatory action of capsaicin and its unwanted vasoconstrictive effects may precipitate adverse outcomes such as vasospasm and myocardial infarction, especially in the presence of proinflammatory mediators.
Risk Assessment of Ergonomic Risk Factors at Construction Sites

Construction as a complex industry challenges the protection of safety and health of workers who are exposed to many risk factors in construction sites. Exposure to these risk factors may develop Musculoskeletal Disorders (MSDs). The study is aimed at prioritizing Ergonomic Risk Factors (ERFs) in order of risk. To achieve the aim of this study, a questionnaire survey was distributed among respondents randomly selected from construction sites in Malaysia. The results of this study indicated that the most critical ERFs are Extreme hot temperature, Leaning forward/side, twisting the back and Organizational factors, while the least critical ERFs are Kneeling positions on hard surfaces, Holding tools with longitudinal ridges on handles tightly and Using hands or knees as a hammer. Identification of ERFs and their risk levels are the results of this study. Successful safety performance and management necessitate the investigation of ERFs and hazards regarding risk levels.
A broadband low‐profile cylindrical monopole antenna top loaded with a shorted cross patch

With the top loading of a shorted cross patch of equal arm lengths, a cylindrical monopole antenna can have a low profile (about 7.5% of the free‐space wavelength of the center operating frequencies) and broadband operation (larger than 23%). In addition, by comparing to the case of top loading a shorted rectangular patch, the obtained conical radiation patterns of the proposed low‐profile monopole antenna are much more uniform in all of the ϕ‐planes. Details of the proposed antenna and experimental results are presented. © 2002 John Wiley & Sons, Inc. Microwave Opt Technol Lett 32: 186–188, 2002.
Demonstration of Propulsion System for Microsatellite Based on Hydrogen Peroxide in SOHLA-2L Project

An innovative Panel ExTension SATellite (PETSAT) and propulsion system for PETSAT, are presented in this paper. First, we outline what PETSAT is. Next, based on PETSAT ethos, design policy of the propulsion system is provided. According to the policy, we designed propulsion system and concretely estimated and assembled mono-propellant and bipropellant systems, and it indicated that monopropellant propulsion with 50-60 seconds of specific impulse and 1 N of thrust is probable. In the case of bi-propellant, 120-150 seconds of specific impulse is valid even based on the design policy. We conducted captive tests of mono-propellant and bi-propellant propulsions with a breadboard model of propulsion system for PETSAT, and obtained good operations and performances. Based on the test results, we designed and manufactured flight model propulsion system for PETSAT. We are planning to demonstrate it in SOHLA-2L project progressed by the Space Oriented Higashiosaka Leading Association (SOHLA). SOHLA-2L will be the first on-orbit demonstrator of PETSAT in 2008.
An Overview of Some Plant Based Products With Hepatoprotective Activity

In folk medicine there are various medicinal amalgamation possessing hepatoprotective activity. This activity is of significance because several toxins cause liver injury. Hence, many pharmaceutical companies are targeting herbal medicines for the treatment of liver abnormalities and towards evolving a safe and effective formulation with desired route of administration. In current review we have focused on the studies showing hepatoprotective effect using marine compounds and plant derived compounds. Liver disorder, a global health problem, usually include acute or chronic hepatitis, heptoses, and cirrhosis. It may be due to toxic chemicals and certain antibiotics. Uncontrolled consumption of alcohol also affects liver in an unhealthy way. To cure liver disorders several formulations of medicinal plants are being used. It is observed that hepatoprotective effect of plant is mostly due to flavonoids, alkaloids, terpenoids, steroids, and glycoside. A single drug cannot be useful for all the types of liver disorders. Several plant extracts for liver illness results from poisonous chemicals, viruses, extra alcohol consumption, and repeated administration of medication. By using standards of protection and efficacy, manufacture of plant products need to be ruled out. Current review provides an understanding of ethnopharmocology, toxicology of several medicinal plants manifesting hepatoprotective potential. Despite of varied database analysis new discoveries and their probabilities, evidences on viral hepatitis treatment or liver cirrhosis is inadequate. Further information about phytotherapy, toxicology, quality control studies shall be endorsed. Further in depth studies are required to discover quality trait like SAR, MOA, safety and toxicity and therapeutic potential of phytoconstituents in clinical settings.
Exploring the level of utilizing management reports in decision-making in Croatian companies

Effective business decisions have a positive impact on the overall business of a company. Each business decision should be based on relevant, high-quality, and reliable information prepared by a management accountant in accordance with managers’ specific requirements. In order to be support the efficient decision-making process, the management accounting information should be appropriate for a particular business decision, and it should reflect the role, responsibility, and value it has for a manager that participates in the decision-making. This paper aims to investigate whether the management accounting information system is developed in Croatian companies. In order to collect data for the analysis, a web survey was conducted on a representative sample of Croatian companies. Overall, 225 companies from the real sector participated in the survey. The results have shown that managers consider management reports an important basis in decisi-on-making. Furthermore, the findings of this stu dy have shown that managers in large companies use management reports to a greater extent in decision-making than managers in micro, small, and medium-sized companies do.
Comparison of temperature and humidity during MIS 11 and MIS 5e interglacials with the Holocene using stable isotopes in tufa deposits from northern France

Abstract Many recent palaeoclimatic studies have focused on Pleistocene interglacials, especially Marine Isotopic Stages (MIS) 5e and 11, as analogs to our modern interglacial (MIS 1). In continental area, archives allowing comparison between interglacials remain scarce. Calcareous tufa deposits, as they are characteristic of these periods and can provide long, almost continuous, palaeoclimatic records through their isotopic content, appear highly suitable for such investigation. In this paper, δ18O and δ13C values from the three well-dated tufas of Saint-Germain-le-Vasson, Caours, and La Celle are combined to compare temperature and moisture conditions prevailing during MIS 1, 5e, and 11, in the Paris Basin. Both Pleistocene interglacials, and especially their optima, appear stronger than the Holocene: MIS 11 was wetter and warmer than both the Holocene and MIS 5e, which itself experienced wetter conditions than the Holocene. These observations are consistent with palaeontological data from the studied sites, especially malacological assemblages, which record, as at other European tufa sites, a relative depletion of molluscan diversity during the Holocene compared with the Pleistocene (MIS 5 and 11) interglacials.
AUTS2 Gene: Keys to Understanding the Pathogenesis of Neurodevelopmental Disorders

Neurodevelopmental disorders (NDDs), including autism spectrum disorders (ASD) and intellectual disability (ID), are a large group of neuropsychiatric illnesses that occur during early brain development, resulting in a broad spectrum of syndromes affecting cognition, sociability, and sensory and motor functions. Despite progress in the discovery of various genetic risk factors thanks to the development of novel genomics technologies, the precise pathological mechanisms underlying the onset of NDDs remain elusive owing to the profound genetic and phenotypic heterogeneity of these conditions. Autism susceptibility candidate 2 (AUTS2) has emerged as a crucial gene associated with a wide range of neuropsychological disorders, such as ASD, ID, schizophrenia, and epilepsy. AUTS2 has been shown to be involved in multiple neurodevelopmental processes; in cell nuclei, it acts as a key transcriptional regulator in neurodevelopment, whereas in the cytoplasm, it participates in cerebral corticogenesis, including neuronal migration and neuritogenesis, through the control of cytoskeletal rearrangements. Postnatally, AUTS2 regulates the number of excitatory synapses to maintain the balance between excitation and inhibition in neural circuits. In this review, we summarize the knowledge regarding AUTS2, including its molecular and cellular functions in neurodevelopment, its genetics, and its role in behaviors.
The rarA gene as part of an expanded RecFOR recombination pathway: Negative epistasis and synthetic lethality with ruvB, recG, and recQ

The RarA protein, homologous to human WRNIP1 and yeast MgsA, is a AAA+ ATPase and one of the most highly conserved DNA repair proteins. With an apparent role in the repair of stalled or collapsed replication forks, the molecular function of this protein family remains obscure. Here, we demonstrate that RarA acts in late stages of recombinational DNA repair of post-replication gaps. A deletion of most of the rarA gene, when paired with a deletion of ruvB or ruvC, produces a growth defect, a strong synergistic increase in sensitivity to DNA damaging agents, cell elongation, and an increase in SOS induction. Except for SOS induction, these effects are all suppressed by inactivating recF, recO, or recJ, indicating that RarA, along with RuvB, acts downstream of RecA. SOS induction increases dramatically in a rarA ruvB recF/O triple mutant, suggesting the generation of large amounts of unrepaired ssDNA. The rarA ruvB defects are not suppressed (and in fact slightly increased) by recB inactivation, suggesting RarA acts primarily downstream of RecA in post-replication gaps rather than in double strand break repair. Inactivating rarA, ruvB and recG together is synthetically lethal, an outcome again suppressed by inactivation of recF, recO, or recJ. A rarA ruvB recQ triple deletion mutant is also inviable. Together, the results suggest the existence of multiple pathways, perhaps overlapping, for the resolution or reversal of recombination intermediates created by RecA protein in post-replication gaps within the broader RecF pathway. One of these paths involves RarA.
The Efficacy of a Commercial Physical Activity Monitor in Longitudinal Tracking of Pulmonary Hypertension Patients

Patients with pulmonary arterial hypertension (PAH) have quality of life (QoL) limitations, decreased exercise capacity, and poor prognosis if left untreated. Standard exercise testing is routinely performed for the evaluation of patients with PAH but may be limited in its ability to monitor activity levels in daily living. We evaluated the validity of the commercial Fitbit Charge HR as a tool to assess real time exercise capacity as compared to standard exercise testing in patients with PAH. Ambulatory pediatric and adult PAH patients were enrolled and given a Fitbit with instructions to continuously wear during waking hours. Subjects underwent a 6-minute walk test (6MWT), cardiopulmonary exercise test (CPET) and an SF-36 QoL survey on the day of enrollment and follow-up. Twenty-seven ambulatory subjects with PH were enrolled and 21 had sufficient data for analyses (median age 25, range 13-59, 14 F) were enrolled. Daily steps measured by the Fitbit had a positive correlation with 6MWT distance (r = 0.72, p = 0.03) and an inverse correlation with WHO functional class. On the QoL survey, 77% reported improvement in energy/fatigue (p = 0.055). At follow up there was a strong correlation between Fitbit steps and role limitations due to physical problems (r = 0.88, p = 0.020) and weaker correlations with less related QoL markers. These findings suggest activity monitors may have potential as a simple/novel method of assessing longitudinal exercise capacity and activity levels in PAH patients. Further study in larger cohorts of patients is warranted to determine the best accelerometric correlates with outcomes.
Integrated Cuk-forward converter for photovoltaic-based LED lighting

An integrated Cuk-forward converter for a photovoltaic (PV)-based light emitting diodes (LED) lighting system is presented. In this converter, the Cuk converter delivers the solar energy via PV cell modules to a battery bank in charging mode during the daytime. However, the zero voltage switching (ZVS) forward converter drives the LED lighting system in discharging mode during the night time. Power switches in the Cuk converter and ZVS forward converter are integrated to reduce the component count and the synchronous switch is used in the circuit to reduce the conduction losses and increase the circuit efficiency. Thus, the advantages of the proposed converter are smaller size, lighter weight, fewer components and higher efficiency. Experimental results based on the laboratory prototype rated at 200 W are presented to verify the effectiveness of the proposed converter.
Cognitive Load Assessment of a Vibrotactile Posture Feedback Chair

In this paper, we evaluate the cognitive load of using a vibrotactile posture feedback chair while performing standard office tasks. Our specific application is seated posture guidance in the office environment. We have instrumented a standard office chair with sensors and vibrotactile actuators to detect and correct a user's seated posture in real-time. A pilot study with 20 subjects (age 25±3.2 years, weight 71.6±17.7kg) was conducted to determine the impact on performance in a typing task while responding to the vibrotactile feedback. We found that 55% of the subjects showed statistically significant decrease in typing performance (p<0.05) during the phases with feedback compared to the phases without feedback. However, 70% of the subjects exhibited an improvement in typing speed from the first to last feedback phases. These findings suggest that although the feedback system temporarily induces greater cognitive load, the load decreases with increased familiarity with the feedback system.
Early Flame Detection by Using Dynamic Accumulated Model

In order to solve the problem of early fire detection in the large space, a dynamic accumulated model is presented. The motion object is firstly obtained by using adaptive background subtraction. Three combined rules for flame detection are utilized. Dynamic accumulated model is implemented to compute the edge flicker of the motion object. Two features including circularity and area change are utilized to distinguished flame from other moving object. Experimental results indicate that the presented method has quick respond and can be used in outdoor environment.
What’s new on the front-line of gout pharmacotherapy?

ABSTRACT Introduction Gout is the most common form of inflammatory arthritis affecting millions of persons around the world. Painful flares and tophaceous deposits are debilitating, reduce quality of life and put strain on health-care systems. Areas Covered This review provides an overview of the treatment of gout flares and lowering serum urate. First line agents are discussed with emphasis on emerging evidence. Novel therapies are also covered. Expert opinion Lifestyle modifications form a part of gout prevention. NSAIDs, colchicine, and glucocorticoids are first line agents for gout flares. The IL-1β antagonists are highly effective for arresting flares but their cost-effectiveness render them salvage therapies. Allopurinol is an agent of first choice for urate lowering therapy. In Southeast Asian and Black populations, screening for HLA*B58:01 mutation is a cost-effective approach to decrease the occurrence of allopurinol hypersensitivity syndrome. Febuxostat is another efficacious urate lowering therapy, but has received a U.S. FDA black box warning for cardiovascular safety. Novel uricosurics are a class for continued drug development; verinurad and arhalofenate are agents with future promise. For patients with recalcitrant gout, pegloticase is effective. Its immunogenicity significantly threatens the achievement of sustained urate lowering responses. Abrogating pegloticase’s immunogenicity with immunomodulatory co-therapy may lend to sustained efficacy.
Risk Identification in Cogeneration (Combined Heat and Power) Projects: A Polish Case Study

The purpose of the article is to define the risk factors in cogeneration projects and to demonstrate that a lack of sufficient identification of risks in different phases affects project implementation. A theoretical study is conducted, which aims to identify risk factors in cogeneration projects, based on case studies of such projects in Poland. The study offers a view at CHP (combined heat and power) projects as extremely dependent on the external environment of the organisation. These projects are subject to many external regulations due to their environmental impact and dynamically changing technical aspects. The biggest technical errors occur at the planning and construction stages. The biggest economic and financial risks occur at the execution stage after 2% and 3% of additional design costs occur, respectively. The authors estimated the risks at different stages of the project and concluded that the total cost of failure in correct identification of the risks at the planning stage exceeded PLN 1.5 billion, which amounted to almost 60% of the total additional costs of materialised project risk. Consequently, the biggest challenges in the area of CHP project management at the planning stage are a thorough identification of risks, and the pricing and planning reactions to risk.
Demonstration of enhancing second harmonic generation wi th doubly resonant metamaterial

We investigate the enhancement of second harmonic (SH) generation in doubly resonant metamaterial. The unit cell consists of two coupled resonators, one of which resonates at the fundamental frequency, whereas the other resonates around the SH frequency. We observe that the SH generation in the doubly resonant metamaterial is 4.6 times as large as that in a singly resonant metamaterial in microwave frequency region.
Assessment of LoRaWAN Transmission Systems Under Temperature and Humidity, Gas, and Vibration Aging Effects Within IIoT Contexts

Within the big picture of the Internet of Things (IoT), a brand new paradigm has risen since few years ago in the context of industrial scenarios: the industrial IoT (IIoT), whose aim is to transplant all of the features, characteristics, and scopes of the IoT into industrial settings. The latter ones might be subject to a wide range of environmental conditions from the point of view of both temperature and relative humidity, along with harmful gases exposure and vibration due to, for instance, machinery. Therefore, whenever their monitoring is performed by means of devoted infrastructures, such extreme working conditions must be born in mind during the pertaining design phases. Mostly, industrial monitoring is put into effect by resorting to wireless sensor networks (WSNs) enabled by low-power wide area network (LPWAN) technologies. This set of facilities includes an ample heterogeneity of standards and techniques. However, the long-range (LoRa) modulation and the LoRa wide area network (LoRaWAN) protocol extensively proved to be reliable and robust alternatives. Thus, in this article, the variations of hardware performances of a LoRaWAN sensor node, in terms of transmission capabilities, due to the changes of temperature and relative humidity, vibration, and gaseous atmospheres, such as CO, NO, and NO2, which are typical of industrial processes, are investigated. In so doing, an aging process due to the aforementioned phenomena was induced. To this end, a measurement campaign within controlled environments (i.e., a climatic chamber, a fume extraction plant, and an ad hoc vibration test bench) was sorted out, whose results show a physiological performances drop that neither undermines the network reliability nor damages the sensor node electronics.