Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring the Role of Salicylic Acid in Regulating the Colonization Ability of Bacillus subtilis 26D in Potato Plants and Defense against Phytophthora infestans

Plant colonization by endophytic bacteria is mediated by different biomolecules that cause dynamic changes in gene expression of both bacteria and plant. Phytohormones, in particular, salicylic acid, play a key role in the regulation of endophytic colonization and diversity of bacteria in methaphytobiome. For the first time it was found that salicylic acid influenced motility in biofilms and transcription of the surfactin synthetase gene of the endophytic strain Bacillus subtilis 26D in vitro. Treatment of Solanum tuberosum plants with salicylic acid, along with B. subtilis 26D, increased the number of endophytic cells of bacteria in potato internal tissues and level of transcripts of bacterial surfactin synthetase gene and decreased transcription of plant PR genes on the stage of colonisation with endophytes. Thus, the production of surfactin plays an important role in endophytic colonization of plants, and salicylic acid has an ability to influence this mechanism. Here we firstly show that plants treated with salicylic acid and B. subtilis 26D showed enhanced resistance to the late blight pathogen Phytophthora infestans, which was accompanied by increase in transcriptional activity of plant PR-genes and bacterial surfactin synthetase gene after pathogen inoculation. Therefore, it is suggested that salicylic acid can modulate physiological status of the whole plant–endophyte system and improve biocontrol potential of endophytic strains.
The Clebsch-Gordan coefficients of permutation groups S(2)-S(6)

The Clebsch-Gordan (CG) coefficients of the permutation groups S(2)-S(6) are calculated by using the eigenfunction method. Phases have been chosen in a consistent way to exhibit as many symmetries for the coefficients as is possible, including non-multiplicity free cases. The CG coefficients of S(2)-S(5) and those for (321)*(321) to (321)5 of S(6) are tabulated in the square root form of rationals. These tables together with the S(6) contains/implies S(5) isoscalar factors published earlier provide a complete tabulation of the S(2)-S(6) CG coefficients given in the Young-Yamanouchi basis.
Role of Deubiquitinases in Parkinson’s Disease—Therapeutic Perspectives

Parkinson’s disease (PD) is a neurodegenerative disorder that has been associated with mitochondrial dysfunction, oxidative stress, and defects in mitophagy as well as α-synuclein-positive inclusions, termed Lewy bodies (LBs), which are a common pathological hallmark in PD. Mitophagy is a process that maintains cellular health by eliminating dysfunctional mitochondria, and it is triggered by ubiquitination of mitochondrial-associated proteins—e.g., through the PINK1/Parkin pathway—which results in engulfment by the autophagosome and degradation in lysosomes. Deubiquitinating enzymes (DUBs) can regulate this process at several levels by deubiquitinating mitochondrial substrates and other targets in the mitophagic pathway, such as Parkin. Moreover, DUBs can affect α-synuclein aggregation through regulation of degradative pathways, deubiquitination of α-synuclein itself, and/or via co-localization with α-synuclein in inclusions. DUBs with a known association to PD are described in this paper, along with their function. Of interest, DUBs could be useful as novel therapeutic targets against PD through regulation of PD-associated defects.
Influence of surface coating on the upconversion emission properties of LaPO4:Yb/Tm core-shell nanorods

A solution based hydrothermal method is used for the preparation of LaPO4:Yb–Tm doped and LaPO4:Yb/Tm core-shell upconverted nanorods. The morphologies, structure, formation mechanism, and upconversion emission properties of these nanocrystals are investigated in detail. Tensile strain is observed for LaPO4:Yb–Tm doped material but compressive strain is obtained for LaPO4:Yb/Tm core-shell material. Analysis suggests that the lattice strain plays an important role on the upconversion emission. Bright blue (475 nm) and red (650 nm) upconversion emissions associated to G14→H36 and F32→H36 transitions were observed and a significant higher in upconversion emission intensity is observed in core-shell nanorods. The effective decay time calculated are 230 and 110 μs for core-shell and doped nanorods, respectively, indicating the removal of surface defects due to surface coating. It reveals that the core-shell structure shows better upconversion emission efficiency.
A Study of the 3.3 and 3.4 μm Emission Features in Proto-Planetary Nebulae

Medium-resolution spectra have been obtained of seven carbon-rich proto-planetary nebulae (PPNs) and one young planetary nebula from 3.2 to 3.8 μm, an interval containing the prominent hydrocarbon C–H stretches at 3.3 and 3.4 μm due to aromatic and aliphatic structures, respectively. The 3.3 μm feature is newly identified in IRAS 23304+6147, 22223+4327, and 06530-0213 and is confirmed in Z02229+6208. Three of the PPNs emit in the 3.4 μm feature, two of these being new identifications, IRAS 20000+3239 and 01005+7910, with two others showing possible detections. The 3.3 and 3.4 μm emission features in IRAS 22272+5435 are seen in the nebula offset from the star but not at the position of the central star, consistent with the 2003 results of Goto et al. A similar distribution is seen for the 3.3 μm feature in IRAS 22223+4327. All of the PPNs except IRAS 22272+5435 show Class A 3 μm emission features. These observations, when combined with those of the approximately equal number of other carbon-rich PPNs previously observed, demonstrate that there are large differences in the 3 μm emission bands, even for PPNs with central stars of similar spectral type, and thus that the behavior of the bands does not depend solely on spectral type. We also investigated other possible correlations to help explain these differences. These differences do not depend on the C/O value, since the Class B sources fall within the C/O range found for Class A. All of these 3.3 μm sources also show C2 absorption and 21 μm emission features, except IRAS 01005+7910, which is the hottest source at B0.
Genome-Wide Analysis of microRNAs and Their Target Genes in Dongxiang Wild Rice (Oryza rufipogon Griff.) Responding to Salt Stress

Rice (Oryza sativa) is a staple food for more than half of the world’s population, and its production is critical for global food security. Moreover, rice yield decreases when exposed to abiotic stresses, such as salinity, which is one of the most detrimental factors for rice production. According to recent trends, as global temperatures continue to rise due to climate change, more rice fields may become saltier. Dongxiang wild rice (Oryza rufipogon Griff., DXWR) is a progenitor of cultivated rice and has a high tolerance to salt stress, making it useful for studying the regulatory mechanisms of salt stress tolerance. However, the regulatory mechanism of miRNA-mediated salt stress response in DXWR remains unclear. In this study, miRNA sequencing was performed to identify miRNAs and their putative target genes in response to salt stress in order to better understand the roles of miRNAs in DXWR salt stress tolerance. A total of 874 known and 476 novel miRNAs were identified, and the expression levels of 164 miRNAs were found to be significantly altered under salt stress. The stem-loop quantitative real-time PCR (qRT-PCR) expression levels of randomly selected miRNAs were largely consistent with the miRNA sequencing results, suggesting that the sequencing results were reliable. The gene ontology (GO) analysis indicated that the predicted target genes of salt-responsive miRNAs were involved in diverse biological pathways of stress tolerance. This study contributes to our understanding of DXWR salt tolerance mechanisms regulated by miRNAs and may ultimately improve salt tolerance in cultivated rice breeding using genetic methods in the future.
A comprehensive variability study of the enigmatic WN8 stars: final results

ABSTRACT As a conclusion of our all-sky variability survey of the ‘enigmatic’ variable WN8stars, we have carried out coordinated multisite photometric and spectroscopicobservations of WN8 stars in 1989 and 1994–1995. We conﬁrm the leading role ofthe stellar core in restructuring the whole wind. This emerges as a statistical trend:the higher the level of the 1continuum (i.e. 1core) light variations, the higher thevariability of the P Cygni edges of the optical emission lines. However, the form ofthe correlation between the light and proﬁle variations is g enerally different for eachindividual star. The high level of activity of WN8 stars may be s upported/induced bypulsational instability. Key words: stars: variables: other – stars: Wolf–Rayet. 1 INTRODUCTION WN8 stars are the direct evolutionary descendants of mas-sive and luminous Of stars (Maeder 1996; Crowther SRobert et al. 1989; Antokhin et al. 1995). (b) Their binaryfrequency is very low (Moffat 1989). Apart from theextremely wide wind-interacting visual binary WR 147(WN8+B0.5 V; Williams et al. 1997; Niemela et al. 1997),claims of suspected short-period binarity among WN8 starshave been mainly based on light-curve variations. The bestexamples are HD 96548\WR 40, with two prevailing peri-odicities in light variations,
Risk Models for Developing Pancreatic Fistula After Pancreatoduodenectomy

Objective: To evaluate the performance of published fistula risk models by external validation, and to identify independent risk factors for postoperative pancreatic fistula (POPF). Background: Multiple risk models have been developed to predict POPF after pancreatoduodenectomy. External validation in high-quality prospective cohorts is, however, lacking or only performed for individual models. Methods: A post hoc analysis of data from the stepped-wedge cluster cluster-randomized Care After Pancreatic Resection According to an Algorithm for Early Detection and Minimally Invasive Management of Pancreatic Fistula versus Current Practice (PORSCH) trial was performed. Included were all patients undergoing pancreatoduodenectomy in the Netherlands (January 2018–November 2019). Risk models on POPF were identified by a systematic literature search. Model performance was evaluated by calculating the area under the receiver operating curves (AUC) and calibration plots. Multivariable logistic regression was performed to identify independent risk factors associated with clinically relevant POPF. Results: Overall, 1358 patients undergoing pancreatoduodenectomy were included, of whom 341 patients (25%) developed clinically relevant POPF. Fourteen risk models for POPF were evaluated, with AUCs ranging from 0.62 to 0.70. The updated alternative fistula risk score had an AUC of 0.70 (95% confidence intervals [CI]: 0.69–0.72). The alternative fistula risk score demonstrated an AUC of 0.70 (95% CI: 0.689–0.71), whilst an AUC of 0.70 (95% CI: 0.699–0.71) was also found for the model by Petrova and colleagues. Soft pancreatic texture, pathology other than pancreatic ductal adenocarcinoma or chronic pancreatitis, small pancreatic duct diameter, higher body mass index, minimally invasive resection and male sex were identified as independent predictors of POPF. Conclusion: Published risk models predicting clinically relevant POPF after pancreatoduodenectomy have a moderate predictive accuracy. Their clinical applicability to identify high-risk patients and guide treatment strategies is therefore questionable.
Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish

Podocytes are exquisitely fashioned kidney cells that serve an essential role in the process of blood filtration. Congenital malformation or damage to podocytes has dire consequences and initiates a cascade of pathological changes leading to renal disease states known as podocytopathies. In addition, animal models have been integral to discovering the molecular pathways that direct the development of podocytes. In this review, we explore how researchers have used the zebrafish to illuminate new insights about the processes of podocyte ontogeny, model podocytopathies, and create opportunities to discover future therapies.
Preparation of VO2 Films with Metal–Insulator Transition on Sapphire and Silicon Substrates by Inductively Coupled Plasma-Assisted Sputtering

We have achieved single phase crystalline VO2 film growth on sapphire (0001) and Si(100) substrates by the introduction of inductively coupled plasma (ICP)-assisted sputtering with an internal coil. The VO2 film on Si substrate showed a metal–insulater (M–I) transition at a temperature of 60°C with three orders of change in resistivity, with a small hysteresis width of 2.2°C for temperature. On the other hand, we could not eliminate vanadium oxides with excess oxygen such as V2O5 and V3O7 from stoichiometric VO2 in conventional reactive magnetron sputtering, regardless of the control maintained over the deposition conditions. The growth of VO2 film under a relatively wide range of deposition conditions in ICP-assisted sputtering is expected to aid in the development of integrated devices based on the M–I transition that is due to strong electron correlation.
Developing and Applying an Urban Resilience Index for the Evaluation of Declining Areas: A Case Study of South Korea’s Urban Regeneration Sites

This study attempts to identify the direction of urban regeneration projects in declining areas by using the concept of urban resilience to cope with climate change and disaster. To this end, urban resilience was classified into a Green Resilient Infrastructure (GRI) and an Interactive Safety System (ISS), through a review of previous studies, and categorized into vulnerability, adaptability, and transformability. A total of 12 detailed indicators were derived and indexed using Euclidean distance. Using the indicators, three Korean urban regeneration targets, in Daegu, Mokpo, and Seosan, were selected to evaluate resilience before and after the urban regeneration plan. Consequently, the postplanning resilience index improved in all three target sites, compared to before the regeneration plan. Additionally, previously the regeneration plan showed lower index values in comparison to places not designated as urban regeneration areas. These results suggest that urban resilience needs to be considered in future urban regeneration projects, and that resilience indicators can be used as a means to set the direction of urban regeneration projects. To improve the overall resilience of a region, these indices can help local government establish a reference point for urban resilience in its region.
Case report: Emapalumab for active disease control prior to hematopoietic stem cell transplantation in refractory systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome

Introduction Macrophage activation syndrome (MAS), a secondary form of hemophagocytic lymphohistiocytosis, is a serious life-threatening complication associated with systemic juvenile idiopathic arthritis (sJIA). MAS is characterized by fever, hepatosplenomegaly, liver dysfunction, cytopenias, coagulation abnormalities, and hyperferritinemia and may progress to multiple organ failure and death. Overproduction of interferon-gamma is a major driver of hyperinflammation in murine models of MAS and primary hemophagocytic lymphohistiocytosis. A subset of patients with sJIA may develop progressive interstitial lung disease, which is often difficult to manage. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can potentially be a curative immunomodulatory strategy for patients with sJIA refractory to conventional therapy and/or complicated by MAS. The use of emapalumab (anti-interferon gamma antibody) for the active control of MAS in refractory cases of sJIA and associated lung disease has not been reported. Herein we report a patient with refractory sJIA complicated by recurrent MAS and lung disease that was managed with emapalumab and ultimately followed by an allo-HSCT, which resulted in permanent correction of the underlying immune dysregulation and improvement of lung disease. Case Report We present a 4-year-old girl with sJIA complicated by recurrent MAS and progressive interstitial lung disease. She developed a progressively worsening disease that was refractory to glucocorticoids, anakinra, methotrexate, tocilizumab, and canakinumab. She had a chronic elevation of serum inflammatory markers, notably soluble interleukin-18, and CXC chemokine ligand 9 (CXCL9). Emapalumab, initiated at 6 mg/kg (1 dose) and continued at 3 mg/kg twice weekly for a total of 4 weeks, resulted in MAS remission along with normalization of inflammatory markers. The patient received a matched sibling donor allo-HSCT after a reduced-intensity conditioning regimen with fludarabine/melphalan/thiotepa and alemtuzumab, along with tacrolimus and mycophenolate mofetil for graft-vs.-host disease prophylaxis. At 20 months following her transplant, she has maintained a full donor engraftment with complete donor-derived immune reconstitution. She had complete resolution of sJIA symptoms including marked improvement in her lung disease along with normalization of serum interleukin-18 and CXCL9 levels. Conclusion The use of emapalumab followed by allo-HSCT could help achieve a complete response in refractory cases of sJIA complicated by MAS who have failed standard treatment.
Smart Load Monitoring and Controlling Approach Connected to Solar System Using ESP32 and Blynk

This paper presents a smart load monitoring and controlling approach in which power is generated from rooftop solar-battery system. Using the proposed system, the residential customers can monitor and control the power generation and also the consumption of their individual loads continuously and remotely using their mobile gadgets. Information about the amount of energy generation and consumption in any specified timeframe can help users to become more conscious in energy use and thus energy wastage can be reduced. To implement the proposed system, a prototype was developed using an IOT based microcontroller ESP-32. Necessary data i.e. power generation and then consumption by loads are collected using different sensors. Then the system sends the required notifications to the users on their mobile phones using the Blynk app even though they are not at home. The proposed system can also protect the battery through automatically turned off at low battery state when an automatic generator can be used as backup.
Possible and probable languages

Abstract Frederick J. Newmeyer, Possible and Probable Languages: A Generative Perspective on Linguistic Typology. Oxford: Oxford University Press, 2005, x + 278 pages, ISBN 0-19-927433-9, £ 60 (hardback), ISBN 0-19-927434-7, £ 22.99 (paperback).
Bifunctional carbon nanotube networks for supercapacitors

Highly conducting and porous carbon nanotube (CNT) networks are used as the sole electron conducting material in supercapacitors. The high conductivity of CNT networks and the high surface area allow the replacement of both the metallic current collector and the active material that forms one side of the electrochemical double layer. The combination of both functions in one single layer leads to lightweight charge storage devices that can be manufactured using simple and cheap room temperature methods. The authors have demonstrated that the specific capacitance of such CNT electrodes is comparable to that of other carbon electrodes.
First-order reversal curve diagrams of magnetic entities with mean interaction field: A physical analysis perspective

A new approach to the quantitative and physical analysis of first-order reversal curve (FORC) diagrams is presented. Each hysteron in the FORC method represents a magnetic cluster. Starting with a model for a ferromagnetic, isotropic, and monodomain sphere, and adding anisotropy and domain structure, three different types of “basic hysterons” are obtained: vertical reversible and irreversible, and linear. The FORC diagrams of basic hysterons with a mean interaction field were obtained by simulation. From them, the relationships between the characteristics of the hysterons and the FORC distribution function were extracted. Different sets of hysterons can lead to the same FORC distribution function. A positive mean interaction field tends to merge the hysterons on the FORC diagram, while a negative mean interaction field introduces repulsion between them.
Spectral decomposition and multiple periodicities in the photometric light curves of RS CVn stars

A search is made for multiple-periodic structure in a major subset of the RS CVn class of chromospherically active, binary-star systems using a rigorous numerical approach appropriate to unevenly spaced, gapped data. The goal is to characterize properly the spectral content of RS CVn binary light curves and evaluate how this information can constrain current models for the system. Thirty-six RC CVn systems were observed down to a statistical noise level of about 0.01 m. Most of the systems exhibit multiple periodic structure; 14 show changes in the photometric period on a timescale of a few hundred days. A preference is found for photometric periods with timescales near the orbital and half-orbital periods. The effect is particularly strong for the shorter period systems and is interpreted as evidence for synchronous, or near-synchronous, rotation. 9 refs.
Switching between emotions in the twenty-first century attention economy

ABSTRACT The use of naturalistic stimuli in cognitive neuroscience experiments inspires and requires theoretical foundations that bring together different cognitive domains, such as emotion, language, and morality. By zooming in on the digital environments in which we often perceive emotional messages today, and inspired by the Mixed and Ambiguous Emotions and Morality model, we here argue that successfully processing emotional information in the twenty-first century will often have to rely not only on simulation and/or mentalizing, but also on executive control and attention regulation.
Genome-Wide Genetic Structure of Henan Indigenous Chicken Breeds

Simple Summary There are five indigenous chicken breeds in Henan Province, China; however, comprehensive knowledge of their genetic basis is lacking. Therefore, using whole genome resequencing, we examined the genetic make-up, genomic diversity, and migration history of the indigenous Henan chicken populations as well as the selection factors and genes behind the distinct phenotypes of Henan gamecocks. These results will make it easier to comprehend the traits of the germplasm and the potential for using native breeds from Henan. Abstract There are five indigenous chicken breeds in Henan Province, China. These breeds have their own unique phenotypic characteristics in terms of morphology, behavior, skin and feather color, and productive performance, but their genetic basis is not well understood. Therefore, we analyzed the genetic structure, genomic diversity, and migration history of Henan indigenous chicken populations and the selection signals and genes responsible for Henan gamecock unique phenotypes using whole genome resequencing. The results indicate that Henan native chickens clustered most closely with the chicken populations in neighboring provinces. Compared to other breeds, Henan gamecock’s inbreeding and selection intensity were more stringent. TreeMix analysis revealed the gene flow from southern chicken breeds into the Zhengyang sanhuang chicken and from the Xichuan black-bone chicken into the Gushi chicken. Selective sweep analysis identified several genes and biological processes/pathways that were related to body size, head control, muscle development, reproduction, and aggression control. Additionally, we confirmed the association between genotypes of SNPs in the strong selective gene LCORL and body size and muscle development in the Gushi-Anka F2 resource population. These findings made it easier to understand the traits of the germplasm and the potential for using the Henan indigenous chicken.