Miracle-dz/UniFAR-FTUs huggingface dataset:
The Resolution of Kaplan Fiber Injuries Is Observed in a Majority of Cases at 9 Months After Acute Primary Anterior Cruciate Ligament Reconstruction: A Radiological Study

Background: The natural history of Kaplan fiber (KF) injuries after acute primary anterior cruciate ligament (ACL) reconstruction (ACLR) remains unknown. Purpose/Hypothesis: The purpose of this study was to evaluate the temporal change in the magnetic resonance imaging (MRI) appearance of the KF complex after acute primary ACLR. It was hypothesized that KF injuries would resolve with time. Study Design: Case series; Level of evidence, 4. Methods: A retrospective MRI analysis was conducted on 89 patients with ACL-injured knees to assess the change in the radiological appearance of KFs after primary ACLR. Patients who had undergone index MRI and ACLR within 90 days of the injury and further MRI at 9 months after surgery were included. Diagnostic criteria to identify radiological evidence of a KF injury and its subsequent resolution were applied, including the presence of high signal intensity on fluid-sensitive sequences, which is indicative of a pathological process radiologically. The proximity of KFs to the femoral cortical suspensory device (CSD) was noted on MRI scans and quantified in millimeters. Results: A KF injury was identified in 30.3% (27/89) of patients, with isolated high signal intensity observed in an additional 18.0% (16/89). At 9 months, MRI evidence of the reconstitution of the KF complex was found in 51.9% (14/27) of patients, with persistent discontinuity in the remaining patients (13/27). All patients (16/16) with isolated high signal intensity had complete resolution on repeat MRI scans. KF thickening was observed in 26.1% (12/46) of patients with previously healthy KFs and in 25.0% (4/16) with isolated high signal intensity. The CSD was positioned in close proximity (≤6 mm) to the center of the KF attachment in 61.8% (55/89) of patients, and this was associated with increased rates of KF thickening. Conclusion: The KF injury resolved radiologically in over half of the patients at 9 months after acute primary ACLR. High signal intensity in the region of the KFs on index MRI scans resolved in all cases, with evidence of residual KF thickening in only one-quarter of cases on repeat MRI scans, equivalent to the rate in those with healthy KFs. As such, it is not advisable to use high signal intensity on preoperative MRI scans as the sole criterion for the diagnosis of a KF injury. The position of the CSD after ACLR was intimately related to the KF attachment in the majority of patients, which was associated with KF thickening on postoperative MRI scans.
There are three major Neisseria gonorrhoeae β-lactamase plasmid variants which are associated with specific lineages and carry distinct TEM alleles

Neisseria gonorrhoeae is a significant threat to global health with an estimated incidence of over 80 million cases each year and high levels of antimicrobial resistance. The gonococcal β-lactamase plasmid, pbla, carries the TEM β-lactamase, which requires only one or two amino acid changes to become an extended-spectrum β-lactamase (ESBL); this would render last resort treatments for gonorrhoea ineffective. Although pbla is not mobile, it can be transferred by the conjugative plasmid, pConj, found in N. gonorrhoeae . Seven variants of pbla have been described previously, but little is known about their frequency or distribution in the gonococcal population. We characterised sequences of pbla variants and devised a typing scheme, Ng_pblaST that allows their identification from whole genome short-read sequences. We implemented Ng_pblaST to assess the distribution of pbla variants in 15 532 gonococcal isolates. This demonstrated that only three pbla variants commonly circulate in gonococci, which together account for >99 % of sequences. The pbla variants carry different TEM alleles and are prevalent in distinct gonococcal lineages. Analysis of 2758 pbla-containing isolates revealed the co-occurrence of pbla with certain pConj types, indicating co-operativity between pbla and pConj variants in the spread of plasmid-mediated AMR in N. gonorrhoeae . Understanding the variation and distribution of pbla is essential for monitoring and predicting the spread of plasmid-mediated β-lactam resistance in N. gonorrhoeae .
NPLC0393 from Gynostemma pentaphyllum ameliorates Alzheimer's disease‐like pathology in mice by targeting protein phosphatase magnesium‐dependent 1A phosphatase

Alzheimer's disease (AD) is a neurodegenerative disease with clinical hallmarks of progressive cognitive impairment and memory loss. Gynostemma pentaphyllum ameliorates cognitive impairment, but the mechanisms remain obscure. Here, we determine the effect of triterpene saponin NPLC0393 from G. pentaphyllum on AD‐like pathology in 3×Tg‐AD mice and elucidate the underlying mechanisms. NPLC0393 was administered daily in vivo by intraperitoneal injection for 3 months and its amelioration on the cognitive impairment in 3×Tg‐AD mice was assessed by new object recognition (NOR), Y‐maze, Morris water maze (MWM), and elevated plus‐maze (EPM) tests. The mechanisms were investigated by RT‐PCR, western blot, and immunohistochemistry techniques, while verified by the 3×Tg‐AD mice with protein phosphatase magnesium‐dependent 1A (PPM1A) knockdown (KD) through brain‐specific injection of adeno‐associated virus (AAV)‐ePHP‐KD‐PPM1A. NPLC0393 ameliorated AD‐like pathology targeting PPM1A. It repressed microglial NLRP3 inflammasome activation by reducing NLRP3 transcription during priming and promoting PPM1A binding to NLRP3 to disrupt NLRP3 assembly with apoptosis‐associated speck‐like protein containing a CARD and pro‐caspase‐1. Moreover, NPLC0393 suppressed tauopathy by inhibiting tau hyperphosphorylation through PPM1A/NLRP3/tau axis and promoting microglial phagocytosis of tau oligomers through PPM1A/nuclear factor‐κB/CX3CR1 pathway. PPM1A mediates microglia/neurons crosstalk in AD pathology, whose activation by NPLC0393 represents a promising therapeutic strategy for AD.
An Evaluation of the Use of Low-Fidelity and High-Fidelity Mannequins in Clinical Simulations in a Module Preparing Final Year Children’s and General Nursing Students for Internship Placement

ABSTRACT Internationally, the use of simulation-learning environments in nursing education has escalated over the last number of years. Simulations have been recognized as providing clinical opportunities for student nurses to gain experience in a safe and controlled learning environment. A module specifically preparing fourth year children’s and general nursing students for internship was developed. Preparation work for these simulation sessions included a video for the students to watch which demonstrated evidence-based care using sample simulations. This research aims to evaluate two simulation scenarios, using low-fidelity and high-fidelity mannequins for children’s nursing students as part of a nursing module preparing them for internship practice placement. This mixed-methods evaluation survey of students was conducted in one School of Nursing in a Higher Education Institute in Ireland in the academic year 2021–2022. A simulated learning package was created using a partnership approach with members from the Higher Education Institute and the clinical learning site and piloted with 39 students. This was evaluated using an anonymous, online questionnaire with 17 student responses. An ethical exemption was granted for this evaluation. All students reported the use of the simulations, including the pre-simulation video as beneficial to enhance their learning and to prepare them for internship. The use of low-fidelity and high-fidelity mannequins enhanced their learning process. Students recommended implementing further simulations throughout their programme to enhance their learning experiences. The findings of this evaluation can provide guidance to aid future development of interactive simulations in preparing students for practice placements. Both low fidelity and high fidelity have their places in simulation and education, depending on the scenario and associated learning outcomes. Collaboration between academia and clinical practice is crucial, to bridge the theory-practice gap and demonstrate a positive relationship between staff in both settings.
15q26.3 deletions distal to IGF1R cause growth retardation, congenital heart defect and skeletal anomalies: Case report and review of literature

15q26 deletion is a rare genomic disorder characterized by intrauterine and postnatal growth retardation, microcephaly, intellectual disability, and congenital malformations. Here, we report a 4‐month‐old female with intrauterine growth retardation, short stature, pulmonary hypertension, atrial septal defect and congenital bowing of long bones of the legs. Chromosomal microarray analysis showed a de novo deletion of approximately 2.1 Mb at 15q26.3 region that does not include IGF1R. Our analysis of patients documented in the literature and the DECIPHER database with 15q26 deletions distal to IGF1R, including 10 patients with de novo pure deletions, allowed us to define the smallest region of overlap to 686 kb. This region includes ALDH1A3, LRRK1, CHSY1, SELENOS, SNRPA1, and PCSK6. We propose haploinsufficiency of one or more genes, besides IGF1R, within this region may contribute to the clinical findings in patients with 15q26.3 deletion.
Real-time reliability evaluation of two-phase Wiener degradation process

ABSTRACT Reliability modeling and evaluation for the two-phase Wiener degradation process are studied. For many devices, the degradation rates could possibly increase or decrease in a non smooth manner at some point in time due to the change of degradation mechanism. A two-phase Wiener degradation process with an unobserved change point is used to model the degradation process. And we assume that the change point varies randomly from device to device. Furthermore, we integrate historical data and up-to-date observation data to improve the degradation modeling and evaluation based on Bayesian method. The change point between the two phases was obtained based on the Akaike information criterion (AIC) and the criterion of the residual sum of squares. Finally, a real example of liquid coupling devices (LCDs) and a numeric example are discussed to demonstrate the effectiveness of the proposed method. The results show that the proposed method is effective and efficient.
Improved Minmax Control for Industrial Networked Systems Over Imperfect Communication

To cope with control issues of the networked control system under packet losses and uncertainty, an improved state space model-based linear quadratic (LQ) control is proposed in this paper. By extending the state vector with the set-point tracking error, the novel state space model provides more degrees of freedom for the relevant controller design through adjusting the corresponding weighting coefficients of the state variables and tracking error separately. Under such advantages, the proposed LQ scheme provides improved control performance compared with conventional LQ strategy in which only the original state variables can be weighted. A case study on the temperature regulation of an industrial coke furnace under uncertainty and packet losses is introduced to verify the effectiveness of the proposed control scheme in comparison with conventional LQ strategy.
Towards probing the internal angular momentum distribution in red giants from solar-like oscillations

As red giants show very low surface velocities, rotational splitting has not been detected so far in their comb-like structure from solar-like oscillations. We propose to study the rotational splitting of l=3 modes to discriminate between the competing effects of rotational splitting and finite mode lifetime. Modes of different radial orders probe different depth. The information of rotational splitting with respect to the radial order could lead to an estimate of the magnitude of differential rotation inside their convective layers. This is a first attempt to measure the magnitude of the differential rotation in these evolved stars. An extensive spectroscopic multi-site campaign to study solar-like oscillations in two promising targets, γ Psc and θ 1 Tau is being set up for the second half of 2010. The observational result will be confronted with state-of-the-art models. Independent from the outcome on differential rotation, strong constraints on the models of red giants will be set. γ Psc and θ 1 Tau will provide an optimal case to test the underlying physics.
Hepatitis delta virus RNA decline post inoculation in human NTCP transgenic mice is biphasic

Background and Aims Chronic infection with hepatitis B and hepatitis delta viruses (HDV) is considered the most serious form of viral hepatitis due to more severe manifestations of and accelerated progression to liver fibrosis, cirrhosis, and hepatocellular carcinoma. There is no FDA-approved treatment for HDV and current interferon-alpha treatment is suboptimal. We characterized early HDV kinetics post inoculation and incorporated mathematical modeling to provide insights into host-HDV dynamics. Methods We analyzed HDV RNA serum viremia in 192 immunocompetent (C57BL/6) and immunodeficient (NRG) mice that did or did not transgenically express the HDV receptor - human sodium taurocholate co-transporting peptide (hNTCP). Results Kinetic analysis indicates an unanticipated biphasic decline consisting of a sharp first-phase and slower second-phase decline regardless of immunocompetence. HDV decline after re-inoculation again followed a biphasic decline; however, a steeper second-phase HDV decline was observed in NRG-hNTCP mice compared to NRG mice. HDV-entry inhibitor bulevirtide administration and HDV re-inoculation indicated that viral entry and receptor saturation are not major contributors to clearance, respectively. The biphasic kinetics can be mathematically modeled by assuming the existence of a non-specific binding compartment with a constant on/off-rate and the steeper second-phase decline by a loss of bound virus that cannot be returned as free virus to circulation. The model predicts that free HDV is cleared with a half-life of 18 minutes (standard error, SE: 2.4), binds to non-specific cells with a rate of 0.06 hour-1 (SE: 0.03), and returns as free virus with a rate of 0.23 hour-1 (SE: 0.03). Conclusions Understanding early HDV-host kinetics will inform pre-clinical therapeutic kinetic studies on how the efficacy of anti-HDV therapeutics can be affected by early kinetics of viral decline. LAY SUMMARY The persistence phase of HDV infection has been studied in some animal models, however, the early kinetics of HDV in vivo is incompletely understood. In this study, we characterize an unexpectedly HDV biphasic decline post inoculation in immunocompetent and immunodeficient mouse models and use mathematical modeling to provide insights into HDV-host dynamics. Understanding the kinetics of viral clearance in the blood can aid pre-clinical development and testing models for anti-HDV therapeutics.
Subversion of the Complement System by Pseudomonas aeruginosa

Pseudomonas aeruginosa is an opportunistic pathogen heavily implicated in chronic diseases. Immunocompromised patients that become infected with P. aeruginosa usually are afflicted with a lifelong chronic infection, leading to worsened patient outcomes. ABSTRACT Pseudomonas aeruginosa is an opportunistic pathogen heavily implicated in chronic diseases. Immunocompromised patients that become infected with P. aeruginosa usually are afflicted with a lifelong chronic infection, leading to worsened patient outcomes. The complement system is an integral piece of the first line of defense against invading microorganisms. Gram-negative bacteria are thought to be generally susceptible to attack from complement; however, P. aeruginosa can be an exception, with certain strains being serum resistant. Various molecular mechanisms have been described that confer P. aeruginosa unique resistance to numerous aspects of the complement response. In this review, we summarize the current published literature regarding the interactions of P. aeruginosa and complement, as well as the mechanisms used by P. aeruginosa to exploit various complement deficiencies and the strategies used to disrupt or hijack normal complement activities.
Prediction of shunt response in idiopathic normal pressure hydrocephalus by combined lumbar infusion test and preoperative imaging scoring

Idiopathic normal pressure hydrocephalus (iNPH) is a potentially treatable disorder, but prognostic tests or biomarkers are lacking. The aim was to study the predictive power of clinical, neuroimaging and lumbar infusion test parameters (resistance to outflow Rout, cardiac‐related pulse amplitude PA and the PA to intracranial pressure ICP ratio).
Une approche de type k-plus proches voisins pour la régression fonctionnelle

Soit $(X,Y)$ un couple aleatoire a valeurs dans $\mathcalH\times\mathbbR$, ou $\mathcalH$ est un espace de Hilbert de dimension infinie. Nous etablissons la convergence faible d'un estimateur de type plus proches voisins de la fonction de regression de $Y$ sur $X$, construit a partir d'observations independantes du couple $(X,Y)$. Comme methode generale, nous proposons de reduire la dimension de $\mathcalH$ en ne considerant que les $d$ premiers coefficients de la projection de $X$ dans une base orhonormale de $\mathcalH$, puis d'appliquer une regression de type plus proches voisins dans $\mathbbR^d$. La dimension et le nombre de voisins sont automatiquement choisis a partir des observations, en utilisant un outil classique de ``data-splitting''.
A Synoptic Climatology of the Elevated Mixed-Layer Inversion over the Southern Great Plains in Spring. Part II: The Life Cycle of the Lid

Abstract This study documents the cycle of lid formation and dissipation over the central U.S. during the spring season(defined as April, May, and June). The primary area of interest is Kansas, Oklahoma, and Texas; however, thestudy encompasses the surrounding states and the source regions for the elevated mixed layer, such as thewestern U.S. and northern Mexico. The database includes conventional surface and rawinsonde observations,as well as derived parameters that define the lid structure. We examine the temporal and spatial variability oflid occurrence and the associated surface/500-mb synoptic patterns to determine the periodicity of lid occurrence,seasonal tendencies, and relationships between different slages of the lid cycle and specific synoptic flow types. Our results indicate that the lid cycle has a mean period of about one week. Synoptic typing shows that thereare basically two types of lid cycles: one that begins with a surface high pressure incursion into the southernPlains, and one that be.
Temperature decoupled viscosity-density product measurement in liquid by utilizing a dual-mode AlN-based acoustic wave resonator

In this letter, we report a two-in-one acoustic wave resonator with Rayleigh and Lamb modes for temperature decoupled viscosity-density product sensing. The Lamb mode of the resonator is sensitive to both the viscosity-density product and the ambient temperature, while the Rayleigh mode only responds to the ambient temperature and is not affected by liquid properties. These unique characteristics of the two modes are due to the different spatial distributions of the acoustic energy. Taking advantage of the aforementioned features, a beat frequency strategy is proposed to decouple the temperature influence from the viscosity-density product measurement, thus realizing temperature independent viscosity-density product sensing in a single acoustic wave resonator chip. Experimental results show that the accurate measurement of the viscosity-density product can be achieved in Newtonian liquids with a sensitivity of −0.36 MHz/kg m−2 s−0.5 within a wide temperature range from 20 °C to 80 °C. Our work holds great promise for liquid property measurement occasions with large fluctuations in ambient temperature, such as oil and gas exploration, automobile, and aeronautic applications.In this letter, we report a two-in-one acoustic wave resonator with Rayleigh and Lamb modes for temperature decoupled viscosity-density product sensing. The Lamb mode of the resonator is sensitive to both the viscosity-density product and the ambient temperature, while the Rayleigh mode only responds to the ambient temperature and is not affected by liquid properties. These unique characteristics of the two modes are due to the different spatial distributions of the acoustic energy. Taking advantage of the aforementioned features, a beat frequency strategy is proposed to decouple the temperature influence from the viscosity-density product measurement, thus realizing temperature independent viscosity-density product sensing in a single acoustic wave resonator chip. Experimental results show that the accurate measurement of the viscosity-density product can be achieved in Newtonian liquids with a sensitivity of −0.36 MHz/kg m−2 s−0.5 within a wide temperature range from 20 °C to 80 °C. Our work holds great.
Pain, mental health and healthcare utilization: Impact of the COVID‐19 pandemic on youth with chronic pain, parents and siblings

Paediatric chronic pain was a public health emergency before the novel coronavirus (COVID‐19) pandemic, and this problem is predicted to escalate. Pain tends to occur intergenerationally in families, and youth with chronic pain and their parents have high rates of mental health issues, which can further exacerbate pain. Siblings of youth with chronic pain have been largely overlooked in research, as well as the impact of the pandemic on posttraumatic stress disorder (PTSD) symptoms and healthcare utilization.
On the Dynamics of the Largest Active Region of the Solar Cycle 24

Abstract We have studied the dynamics of the solar active region (AR) NOAA 12192 using full-disc continuum images and the vector magnetograms observed by the Helioseismic and Magnetic Imager (HMI) onboard Solar Dynamics Observatory (SDO). AR 12192 is the largest region of the solar cycle 24. It underwent a noticeable growth and produced 6 X-class, 22 M-class and 53 C-class flares during its disc passage. But the most peculiar fact of this AR is that it was associated with only one CME in spite of producing several X-class flares. In this work, we present the area evolution of this giant sunspot group during the first three rotations when it appeared as AR 12172, AR 12192 and AR 12209, respectively. We have also attempted to make a comparative study of the flare-related photospheric magnetic field and Lorentz force changes for both the eruptive and non-eruptive flares produced by AR 12192.