Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of mica powder-filled styrene-butadiene rubber compounds on crosslink density and mechanical properties

In this study, four different compounds were produced by adding different proportions of mica powder (0-5-10-20%) to styrene-butadiene rubber. After vulcanization, the crosslink density, hardness, density, tensile strength, elongation percentage, and tearing strength of the compounds were measured. In addition, the effects of crosslink density on mechanical properties were discussed. The physio-mechanical properties of the new compounds produced were compared both among them? selves and with the properties of the rubber being referenced. It was observed that increasing the crosslink density of mica powder provided an advantage in terms of hardness, tensile strength, tearing strength, and percentage elongation properties. To explain the changes in mechanical properties, the tensile fracture surfaces were determined by SEM and energy dispersive spectroscopy. In the light of the obtained results, it was determined that the use of carbon black could be reduced by using mica powder in the rubber industry.
Nutritive Value of Cistus ladanifer L. for Ruminants: Seasonal Variation of Chemical Composition, Digestibility, and Antioxidant Activity of Its Morphological Fractions

Cistus ladanifer has been used in ruminants feeding systems, but there is no information about the seasonal variation in chemical composition and nutritional value of each morphological fraction during its growth cycle. This study characterized the morphological fractions of C. ladanifer (leaves, stems, flower buds, flowers, and seed heads) throughout the year in chemical composition, in vitro digestibility, and antioxidant activity. The leaves were the morphological fraction more variable throughout the seasons, being characterized by low protein level (48.5–114 g/kg dry matter (DM)), moderate cell-wall content (240–267 g NDF/kg DM), high levels of condensed tannins (CT) (131–246 g/kg DM), and low in vitro organic matter digestibility (IVOMD) (29.3–34.3%). The distinctive chemical composition among various morphological fractions allowed the identification of four distinct groups, the first composed by stems, the second by the leaves, the third by the seed heads, and the last one by the flower buds and flowers. All the morphological fractions are sources of bioactive compounds namely phenolic compounds. Leaves are the fraction with higher nutritive value, especially when collected during winter and spring.
The Coronavirus Pandemic: A Possible Model of the Direct and Indirect Impact of the Pandemic on Sleep Quality in Italians

Purpose: This study aimed to assess the direct and indirect impact of COVID-19-related aspects on self-reported sleep quality, considering the moderator role of some psychological variables. Methods: During the first weeks of the lockdown in Italy, 2286 respondents (1706 females and 580 males; age range: 18–74 years) completed an online survey that collected socio-demographic information and data related to the experience with the COVID-19 pandemic. Some questionnaires assessed sleep quality, psychological well-being, general psychopathol-ogy, Post-Traumatic Stress Disorders symptoms, and anxiety. The path analysis was adopted. Results: The study confirms a direct effect of some aspects ascribable to the pandemic, with a mediator role of the psychological variables. Lower sleep quality was directly related to the days spent at home in confinement and the knowledge of people affected by the COVID-19. All the other aspects related to the COVID-19 pandemic influenced sleep quality through the mediator effect of psychological variables. Conclusion: This study highlighted that the psychological condition of the population has been influenced by the COVID-19 pandemic and the government actions taken to contain it, but it has also played an important role in mediating the quality of sleep, creating a vicious circle on people’s health. The results suggest that a health emergency must be accompanied by adequate social support programs to mitigate the fear of infection and promote adequate resilience to accept confinement and social distancing. Such measures would moderate psychological distress and improve sleep quality.
The application of daylighting software for case-study design in buildings

The application of different software, whether simple or complex, can each play a significant role in the design and decision-making on daylighting for a building. This paper, discusses the task to be accomplished, in real case studies, and how various lighting software programs are used to achieve the desired information. The message iterated throughout the paper is one that respects, and even suggests, the use of even the simplest software, that can guide and inform design decisions in daylighting. Daylighting can be complex since the position of the sun varies throughout the day and year as well as do the sky conditions for a particular location. Just because we now have the computing capacity to model every single minute of a day throughout a year, doesn't justify its task. Several projects; an architecture studio, a university office building, a school library and a gymnasium all present different tasks to be achieved. The daylighting problems, the objects and the software application and their outcomes are presented in this paper. Over a decade of projects has led to reflecting upon the importance of computing in daylighting, its staged approach and the result that it can achieve if properly applied.
Using Agaricus bisporus filterate and sodium citrate against Alternaria arborescens toxicity in histopathological and biochemical change in laborotary mices

This study was designed to find out the therapeutic efficiency of Argaricus bisporus fungi in the treatment of toxicity caused by fungus Alternaria aborescens, in the study (30) of female mice injury experimentally six groups of a single dose of (0.5)lµ size oral dosing using a stomach tube . Results of the study pathological macroscopic and histopathological ability of toxic fungus filtarate to the events of infection when an autopsy after (21days) from injury was infiltration of cells of the inflammatory and as well as caused histological clear in the cross-section of the liver tissue, including the occurrence of vaculation of hepatic cells and the presence of bubbles in the cytoplasmic cells and the expansion of the hepatic siousoid , causing hydropic degeneration. Resalts showed a clear effect within the kidney tissues leading to atrophy in glomeruli, lymphocytic infiltration and hemorrhage, in addition to the degradation of urinary tubule cells , which affects the functions of the kidney leading to renal fialure . proved the results obtained from the study of histological sections impact the effective and positive role for the test in the treatment represented by a restoration of the Liver and kidneys tissues to be mounted typical natural.
Sex-Related Differences of Matrix Metalloproteinases (MMPs): New Perspectives for These Biomarkers in Cardiovascular and Neurological Diseases

It is now established that sex differences occur in clinical manifestation, disease progression, and prognosis for both cardiovascular (CVDs) and central nervous system (CNS) disorders. As such, a great deal of effort is now being put into understanding these differences and turning them into “advantages”: (a) for the discovery of new sex-specific biomarkers and (b) through a review of old biomarkers from the perspective of the “newly” discovered sex/gender medicine. This is also true for matrix metalloproteinases (MMPs), enzymes involved in extracellular matrix (ECM) remodelling, which play a role in both CVDs and CNS disorders. However, most of the studies conducted up to now relegated sex to a mere confounding variable used for statistical model correction rather than a determining factor that can influence MMP levels and, in turn, disease prognosis. Consistently, this approach causes a loss of information that might help clinicians in identifying novel patterns and improve the applicability of MMPs in clinical practice by providing sex-specific threshold values. In this scenario, the current review aims to gather the available knowledge on sex-related differences in MMPs levels in CVDs and CNS conditions, hoping to shed light on their use as sex-specific biomarkers of disease prognosis or progression.
Constrained mean‐variance mapping optimization for truss optimization problems

Truss optimization is a complex structural problem that involves geometric and mechanical constraints. In the present study, constrained mean‐variance mapping optimization (MVMO) algorithms have been introduced for solving truss optimization problems. Single‐solution and population‐based variants of MVMO are coupled with an adaptive exterior penalty scheme to handle geometric and mechanical constraints. These tools are explained and tuned for weight minimization of trusses with 10 to 200 members and up to 1,200 nonlinear constraints. The results are compared with those obtained from the literature and classical genetic algorithm. The results show that a MVMO algorithm has a rapid rate of convergence and its final solution can obviously outperform those of other algorithms described in the literature. The observed results suggest that a constrained MVMO is an attractive tool for engineering‐based optimization, particularly for computationally expensive problems in which the rate of convergence and global convergence are important.
CNS TB-IRIS Following Cessation of Adalimumab in an Adolescent With Crohn’s Disease

Abstract Immune reconstitution inflammatory syndrome to tuberculosis (TB-IRIS) is an inflammatory response to M. tuberculosis infection that arises following restoration of the immune system and is increasingly recognized as a risk in patients treated with tumor necrosis factor α inhibitors who develop active tuberculosis infection. We present the case of a 19-year-old man treated with adalimumab for Crohn’s disease who presented with disseminated miliary tuberculosis. His treatment course was complicated by central nervous system TB-IRIS following cessation of his immunosuppression. We review the presentation and differential diagnosis of TB-IRIS, as well as risk factors for developing IRIS and the treatment of IRIS in this population.
The Experience Cylinder, an immersive interactive platform: The Sea Stallion's voyage: a case study

—This paper describes the development of an experimental interactive installation, a so-called “experience cylinder”, intended as a travelogue and developed specifically to provide a narrative about the Viking ship Sea Stallion’s voyage from Roskilde to Dublin and back. The installation provides a framework for individual experience of the Sea Stallion's voyage, where a user among the audience interacts with the installation. Interaction is mainly by position and gesture tracking and feedback is by selection and projection of objects, such as photos, videos, background images, synthesized sound and recited stories. All combine to provide an individual path of choice through a coherent story told by means of a cylindrical screen, enclosing a space providing 3D positional sound following the interacting user and exploiting data such as wind, wave and weather logs through 3D sound effects. While being intended to tell a story about a certain voyage the resulting installation has been developed as an open interactive platform suitable for story-telling/travelogue. First and foremost the platform provides an approach to easy and intuitive navigation within heterogeneous media material comprising a large number of media objects.
miR-218: A Stress-Responsive Epigenetic Modifier

Understanding the epigenetic role of microRNAs (miRNAs) has been a critical development in the field of neuropsychiatry and in understanding their underlying pathophysiology. Abnormalities in miRNA expression are often seen as key to the pathogenesis of many stress-associated mental disorders, including major depressive disorder (MDD). Recent advances in omics biology have further contributed to this understanding and expanded the role of miRNAs in networking a diverse array of molecular pathways, which are essentially related to the stress adaptivity of a healthy brain. Studies have highlighted the role of many such miRNAs in causing maladaptive changes in the brain’s stress axis. One such miRNA is miR-218, which is debated as a critical candidate for increased stress susceptibility. miR-218 is expressed throughout the brain, notably in the hippocampus and prefrontal cortex (PFC). It is expressed at various levels through life stages, as seen by adolescent and adult animal models. Until now, a minimal number of studies have been conducted on human subjects to understand its role in stress-related abnormalities in brain circuits. However, several studies, including animal and cell-culture models, have been used to understand the impact of miR-218 on stress response and hypothalamic-pituitary-adrenal (HPA) axis function. So far, expression changes in this miRNA have been found to regulate signaling pathways such as glucocorticoid signaling, serotonergic signaling, and glutamatergic signaling. Recently, the developmental role of miR-218 has generated interest, given its increasing expression from adolescence to adulthood and targeting the Netrin-1/DCC signaling pathway. Since miR-218 expression affects neuronal development and plasticity, it is expected that a change in miR-218 expression levels over the course of development may negatively impact the process and make individuals stress-susceptible in adulthood. In this review, we describe the role of miR-218 in stress-induced neuropsychiatric conditions with an emphasis on stress-related disorders.
Molecular detection of a polymorphism in the p53 codon 72 gene and its association with prostate cancer

The role of the current study in detecting polymorphisms in the gene P53codon72, a gene that has morphological polymorphism and has an important role in the incidence of diseases, especially cancers such as prostate cancer, samples for the study were collected from 50 patients with prostate cancer from the auditors of the Imam Hussein Center for Cancer and Diseases Blood in Al-Hussein, peace be upon him, Teaching Hospital - Holy Karbala Governorate - Iraq After diagnosis by a specialist surgeon and 50 phenotypically healthy individuals as a control group, the (DNA) was extracted from the blood of both healthy and all patients study groups, and molecular detection of polymorphism of nucleotides was performed in Genes of the study using PCR-RFLP Molecular detection results in P53codon72 The results showed that there were highly significant differences between the genotype (Pro-Pro) and between the infected and healthy groups as well as the genotype (Arg-Arg), while there was no significant relationship between the genotype (Arg-Pro) and between the infected and healthy groups. The results also showed highly significant differences between the three genotypes (Arg/ Arg, Aro/Pro, Pro/Pro) and between the two groups sick and healthy.
Dataset of Indicators for the Assessment of Ecosystem Services Affected by Agricultural Soil Management

Ecosystem services represent an important concept for assessing the sustainability of agricultural management. However, in practical applications, it can be difficult to find indicators suitable for specific services or specific spatial scales. In order to create a toolbox of indicators for assessing the actual or potential supply of ecosystem services in the context of agricultural land and soil management, we conducted a keyword-based literature review in Web of Science Core Collection and SCOPUS, using the terms ecosystem service AND indicator AND agricultur*. The search was performed in January 2019 and was restricted to journal articles written in English. After eliminating duplicates, we identified 180 articles, out of which 121 met our selection criteria. We extracted information on addressed ecosystem services and indicators which used a full-text review. Where studies used ecosystem service definitions other than the Common International Classification of Ecosystem Services (CICES V.5.1), indicators were assigned to the corresponding CICES class or classes. We used the information derived from the review to create factsheets for 37 ecosystem services. Each factsheet provides tables with available indicators applicable at multiple spatial scales that range from field to global, information on the type of input data required, and a reference to the article or articles that the indicator was taken from. The dataset provides a toolbox for researchers to find indicators that fit their respective research needs.
Multi-Resolution Collaborative Fusion of SAR, Multispectral and Hyperspectral Images for Coastal Wetlands Mapping

The hyperspectral, multispectral, and synthetic aperture radar (SAR) remote sensing images provide complementary advantages in high spectral resolution, high spatial resolution, and geometric and polarimetric properties, generally. How to effectively integrate cross-modal information to obtain a high spatial resolution hyperspectral image with the characteristics of the SAR is promising. However, due to divergent imaging mechanisms of modalities, existing SAR and optical image fusion techniques generally remain limited due to the spectral or spatial distortions, especially for complex surface features such as coastal wetlands. This paper provides, for the first time, an efficient multi-resolution collaborative fusion method for multispectral, hyperspectral, and SAR images. We improve generic multi-resolution analysis with spectral-spatial weighted modulation and spectral compensation to achieve minimal spectral loss. The backscattering gradients of SAR are guided to fuse, which is calculated from saliency gradients with edge preserving. The experiments were performed on ZiYuan-1 02D (ZY-1 02D) and GaoFen-5B (AHSI) hyperspectral, Sentinel-2 and GaoFen-5B (VIMI) multispectral, and Sentinel-1 SAR images in the challenging coastal wetlands. Specifically, the fusion results were comprehensively tested and verified on the qualitative, quantitative, and classification metrics. The experimental results show the competitive performance of the proposed method.
On the Size and Weight of Passive Components: Scaling Trends for High-Density Power Converter Designs

With increasing calls of electrification for trans-portation (e.g, electric vehicles, hybrid or electric aircraft), the need for systematic guidelines that gauge passive component specific energy density for weight-optimized converter design has be-come apparent. Observing a lack of data sets and corresponding modeling process for passive components that usually dominate a converter's weight, this work proposes a transformation that estimates the specific energy density of passive components from comprehensively surveyed volumetric energy density data and empirical specific density models, and thus forms a convenient guideline for converter weight optimization. The proposed model is then applied to a converter designed for electric aircraft applications to showcase the component mass estimation and selection process along with estimation accuracy.
Dynamic performance improvement of New York state power grid with multi-functional multi-band power system stabiliser-based wide-area control

This study demonstrates the application of a wide-area control scheme based on multi-functional multi-band power system stabilisers (MF-MBPSS) in New York State grid for the purpose of system stability improvement. The aspects of oscillation damping, frequency and voltage closed-loop control are considered. The study describes useful techniques for placing and tuning of MF-MBPSSs based on simulation models and suitable techniques for very large power grids. The application of these concepts is demonstrated on a transient stability model of Eastern Interconnection. Results show a reduction of system frequency nadir during generation outages, significant improvement in damping of post-disturbance swings and capabilities to contribute to long-term voltage stability using only a modest amount of dynamic reactive power resources.
ROBUST CONTROL FOR DC-DC BUCK CONVERTER UNDER PARAMETRIC UNCERTAINTIES

 DC-DC Buck Converters are widely used in applications demanding the supply of a constant load voltage. Howev- er, the dynamic behavior of the buck converter may change due to uncertainties such as load and input voltage variations, as well as variations in the components of the buck converter itself. Because of these variations and the nonlinear behavior due to switching, makes the controller design presents some challenges on obtain the desired performance. In order to guarantee stability of the system and to preserve its dynamic performance under parametric uncertainties, in this paper a robust control tech- nique, based on parametric uncertainties, is studied. The controller is designed by robust pole-placement technique based on a desired performance in closed-loop, specified by a family of characteristic polynomials. The design procedure is formulated as a set of linear constraints solved via linear programming methods. A classical controller, based on pole-placement technique, is used for performance comparison. For performance assessment, several tests were carried out in Matlab/Simulink environment. By calculating the ISE (integral square error) performance index, the obtained results show that the proposed controller obtain robust performance. quadrado integral) mostram que o controlador proposto apresenta desempenho com melhor desempenho robusto. Palavras-chave  conversor buck, conversores CC-CC, incertezas paramétricas, programação linear.
Multi-Omic Biomarkers for Patient Stratification in Sjogren’s Syndrome—A Review of the Literature

Sjögren’s syndrome (SS) is a heterogeneous autoimmune rheumatic disease (ARD) characterised by dryness due to the chronic lymphocytic infiltration of the exocrine glands. Patients can also present other extra glandular manifestations, such as arthritis, anaemia and fatigue or various types of organ involvement. Due to its heterogenicity, along with the lack of effective treatments, the diagnosis and management of this disease is challenging. The objective of this review is to summarize recent multi-omic publications aiming to identify biomarkers in tears, saliva and peripheral blood from SS patients that could be relevant for their better stratification aiming at improved treatment selection and hopefully better outcomes. We highlight the relevance of pro-inflammatory cytokines and interferon (IFN) as biomarkers identified in higher concentrations in serum, saliva and tears. Transcriptomic studies confirmed the upregulation of IFN and interleukin signalling in patients with SS, whereas immunophenotyping studies have shown dysregulation in the immune cell population frequencies, specifically CD4+and C8+T activated cells, and their correlations with clinical parameters, such as disease activity scores. Lastly, we discussed emerging findings derived from different omic technologies which can provide integrated knowledge about SS pathogenesis and facilitate personalised medicine approaches leading to better patient outcomes in the future.
COMMENT: Some more exact enumeration results for 1D cellular automata

The author presents exact enumeration results for the elementary cellular automation rules 22, 30, 45 and 120 in Wolfram's notation. Obtained by a new algorithm, they improve previous results considerably. They confirm the existence of 'hidden' power-behaved long-range correlations in the patterns created by these rules.