Miracle-dz/UniFAR-FTUs huggingface dataset:
SEVERITY OF THE COMPONENTS OF HARDINESS IN VICTIMIZED ADOLESCENT MIGRANTS

Due to chronic stress associated with changes in living conditions and new socio-cultural context, adolescent migrants are at high risk of experiencing bullying, violence, and aggression. Hence, the question arises as to what personality traits should be formed as a basis for adolescent migrants to maintain a productive level of efficiency, functionality, and establish normal relationships with peers. The author claims that this trait is hardiness. The paper provides a theoretical and empirical analysis of the problem of hardiness of victimized adolescents from migrant families and a number of excerpts from the works of various authors on the victimhood of adolescents and adolescent migrants. A total of 72 teenage migrants were involved in the experimental study. At the first stage of the study, the features of victim behavior in adolescent migrants were determined. At the second stage, the level of hardiness and its components in adolescent migrants was identified. The correlation analysis of hardiness indicators and victim behavior characteristics revealed reliable relationships between the components of hardiness and the indicators of victimhood. The results of the study yielded the conclusion that hardiness is a resource for overcoming the victimhood in adolescent migrants.
Barriers to Adoption of Wellness Programs: A Worked Example of an Augmented Best-Fit Framework Synthesis

s were reviewed if they appeared to fit the problem of practice. Full-texts were downloaded for further review if the abstract noted the use of a potentially relevant theory and evaluated the phenomenon of program adoption. Diffusion Theory (DT) was selected due to its overwhelmingly frequent mention as well as its direct applicability to this paper’s problem of
Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences

and Tom70. In this study, we show that many preproteins contain additional internal MTS-like signals (iMTS-Ls) in their mature region that share the characteristic properties of presequences. These features allow the in silico prediction of iMTS-Ls. Using Atp1 as model substrate, we show that iMTS-Ls mediate the binding to Tom70 and have the potential to target the protein to mitochondria if they are presented at its N terminus. The import of preproteins with high iMTS-L content is significantly impaired in the absence of Tom70, whereas preproteins with low iMTS-L scores are less dependent on Tom70. We propose a stepping stone model according to which the Tom70-mediated interaction with internal binding sites improves the import competence of preproteins and increases the efficiency of their translocation into the mitochondrial matrix.
EVALUATION OF DIFFERENT OPTIMIZED PARAMETERS DURING COMPOSTING PROCESS

Composting process can be increased and improved by optimizing different parameters. These important parameters include pH, C: N, Moisture %, temperature, aeration and weight of the windrow. The reading of the temperature and oxygen was taken on daily basis while the reading of other optimized was taken weekly. It was concluded that the variation in the reading of these optimized parameters were observed at the start and end of the process and this variation in the value of the optimized parameters was a positive sign of early degradation of organic waste.
Human T-Cell Leukemia Virus Type I Tax Associates with and Is Negatively Regulated by the NF-iB2 plOO Gene Product: Implications for Viral Latency

Human T-cell leukemia virus type I (HTLV-I) is the etiologic agent of the adult T-cell leukemia, an aggressive and often fatal malignancy of activated human CD4 T cells. HTLV-I encodes an essential 40-kDa protein termed Tax that not only transactivates the long terminal repeat of this retrovirus but also induces an array of cellular genes. Tax-mediated transformation of T cells likely involves the deregulated expression of various cellular genes that normally regulate lymphocyte growth produced by altered activity of various endogenous host transcription factors. In particular, Tax is capable of modulating the expression or activity of various host transcription factors, including members of the NF-KB/Rel and CREB/ATF families, as well as the cellular factors HEB-1 and p67s"r. An additional distinguishing characteristic of HTLV-I infection is the profound state of viral latency that is present in circulating primary leukemic T cells. In this study, we demonstrate that HITLV-I Tax can physically associate with plO0, the product of the Rel-related NF-KB2 gene, both in transfected cells and in HTLV-I-infected leukemic T-cell lines. Furthermore, the physical interaction of Tax with plO0 leads to the inhibition of Tax-induced activation of the HTLV-I and human immunodeficiency virus type 1 long terminal repeats, reflecting plO0-mediated cytoplasmic sequestration of the normally nucleariy expressed Tax protein. In contrast, a mutant of Tax that selectively fails to activate nuclear NF-KB expression does not associate with plO0. Together, these results suggest that the cytoplasmic interplay of Tax and plO0 may play an important role in the initiation and maintenance of HTLV-I latency observed in adult T-cell leukemia.
The effect of melatonin on delirium incidence in orthopedic patients: a clinical trial study

Introduction: Delirium is an acute psychiatric condition that can lead to very unpleasant consequences in post-operative orthopedics patients. Therefore, extensive studies have been done on the diagnosis, prevention and treatment of cognitive impairment especially delirium in patients admitted to the intensive care unit, orthopedic surgeries, organ transplantation and heart surgery departments. The aim of this study was to determine the efficacy of melatonin on prevention of delirium in orthopedics patients. Materials and methods: The present study was a double-blind randomized clinical trial which was performed on 100 patients admitted to orthopedics department. Patients were randomly divided into two groups to achieve optimal matching, using random numbers table. The first group received sublingual melatonin from the day before the surgery and on days 1, 2 and 3 after the operation, and second group received placebo. All of the two groups were evaluated for delirium on a daily basis (from day before surgery to 3 days later) at a specific and identical hour by a fixed and definite person by using the CAM test. Result: In this study, 100 patients were examined. The results showed that the mean age in the case group was 42.88 years with a standard deviation of 12.53, while the control group was 46.94 years with a standard deviation of 15.42 and there was no significant difference between the two groups according to p =0.152. Also, there was no significant difference in gender and educational level of patients in the two groups. The results of the CAM test showed no significant difference between the two groups on the day before and the first, second and third days after the operation. Conclusion: According to the results of this study, the administration of melatonin did not have an effect on the incidence of delirium in the orthopedics department, but extensive multi-center studies and the use of different doses of the drug could be useful in determining the optimal dose of melatonin.
signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells

Oncogene-induced senescence (OIS), the proliferative arrest en- gaged in response to persistent oncogene activation, serves as an important tumor-suppressive barrier. We show here that ﬁ nite lifespan human mammary epithelial cells (HMEC) undergo a p16/ RB- and p53-independent OIS in response to oncogenic RAS that requires TGF- β signaling. Suppression of TGF- β signaling by expression of a dominant-negative TGF- β type II receptor, use of a TGF- β type I receptor inhibitor, or ectopic expression of MYC permitted continued proliferation upon RAS expression. Surprisingly, unlike ﬁ broblasts, shRNA-mediated knockdown of ATM or CHK2 was unable to prevent RAS-mediated OIS, arguing that the DNA damage response is not required for OIS in HMEC. Abrogation of TGF- β signaling not only allowed HMEC lacking p53 to tolerate oncogenic RAS but also conferred the capacity for anchorage-independent growth. Thus, the OIS engaged after dysregulated RAS expression provides an early barrier to malignant progression and is mediated by TGF- β receptor activation in HMEC. Understanding the mechanisms that initiate and maintain OIS in epithelial cells may provide a foundation for future therapies aimed at reengaging this proliferative barrier as a cancer therapy.
Neurotoxicity of Fruits, Seeds and Leaves of Plants in the Annonaceae Family

Fruits, seeds, twigs and leaves of several plants in the Annonaceae family contain neurotoxic compounds called acetogenins. Overconsumption of at least one of these fruits, graviola (Annona Muricata), caused an atypical form of Parkinson’s disease on the islands of Guadeloupe, Guam and New Caledonia. It does not respond to the standard treatment with L-Dihydroxyphenylalanine (L-DOPA). This type of atypical Parkinsonism is similar to progressive supranuclear palsy, but with important differences. It is characterized by L-DOPA-resistant Parkinsonism, tremor, subcortical dementia and abnormal eye movements suggestive of Progressive Supranuclear Palsy (PSP). Patients also have hallucinations and dysautonomia, which are not characteristic of PSP. Furthermore, the oculomotor abnormalities and the tremor, which is jerky, differ from what is observed in classical PSP patients. The neurotoxicity is caused by mitochondrial dysfunction. A class of compounds called Acetogenins (ACGs) inhibits the mitochondrial NADH: Ubiquinone Oxidoreductase (complex-I of the respiratory chain). These compounds are lipophilic polyketides that are found in plants in the Annonaceae family. They have two toxicophores: a γ-Butyrolactone and one or more Tetrahydrofuran (THF) or Tetrahydropyran (THP) rings. There is also a long chain alkyl group on the other end of the molecule. Even though it strongly affects the physical-chemical properties of ACGs, it is not a toxicophores. Over 400 ACGs have been found in different plants in the Annonaceae family. They can be identified by Nuclear Magnetic Resonance (NMR) and liquid chromatography coupled to mass spectrometry (LC-MS). They form adducts with Ca 2+ and Mg 2+ , which helps to confirm their presence in samples.
Mutagenesis and Stress Responses Induced in Escherichia coli by Hydrogen Peroxide

Killing of Escherichia coli by hydrogen peroxide proceeds by two modes. Mode one killing appears to be due to DNA damage, has a maximum near 1 to 3 mM H202, and requires active metabolism during exposure, Mode two killing is due to uncharacterized damage, occurs in the absence of metabolism, and exhibits a classical multiple-order dose-response curve up to at least 50 mM H202 (J. A. Imlay and S. Linn, J. Bacteriol. 166:519-527, 1986). H202 induces the SOS response in proportion to the degree of killing by the mode one pathway, i.e., induction is maximal after exposure to 1 to 3 mM H202. Mutant strains that cannot induce the SOS regulon are hypersensitive to peroxide. Analysis of the sensitivities of mutants that are deficient in individual SOS-regulated functions suggested that the SOS-mediated protection is due to the enhanced synthesis of recA protein, which is rate limiting for recombinational DNA repair. Specifically, strains wholly blocked in both SOS induction and DNA recombination were no more sensitive than mutants that are blocked in only one of these two functions, and strains carrying mutations in uvrA, -B, -C, or -D, sfiA, umuC or -D, ssb, or dnA, -B, -D, -F, -G, -H, -1, or -J were not abnormally sensitive to killing by 1202. After exposure to H202, mutagenesis and filamentation also occurred with the dose response characteristic of SOS induction and mode one kiling, but these responses were not dependent on the lexA-regulated umuC mutagenesis or sfiA filamentation functions, respectively.
PPA_A_268953 2263..2277

1University of Lyon, University of SaintEtienne, Centre Hygée, HESPER EA 7425, Rue de la Marandière, Saint-Priest-enJarez, 42270, France; 2Oncogeriatrics Department, Lyon Sud Teaching Hospital & Claude Bernard University, Lyon, France; 3Transversal Unit of Patient Education of Department of Rhône, Hospices Civils de Lyon, Lyon 69004, France; 4Public Health Department, Centre Hygée, Institut de Cancérologie Lucien Neuwirth, HESPER EA 7425, Saint-Priest-en-Jarez 42270, France; 5Pharmacy Department, Lyon Sud Teaching Hospital & Claude Bernard University, Lyon, France; 6Medical Oncology Department, Lyon Sud Teaching Hospital & Claude Bernard University, Lyon, France; 7Department of Clinical Research and Innovation, Léon Bérard Cancer Centre, Lyon, France; 8Clinical Epidemiology Unit, Robert Debré Hospital, AP-HP, INSERM CIC-EC 1426; INSERM 1123 ECEVE, University of Paris, Paris, France Introduction: A patient education program has been developed in the field of cancer for supporting cancer patients undergoing oral anticancer therapies. Its implementation was tested in 3 different settings. The objectives of this study were to 1) identify barriers and facilitators for implementing the patient education program, 2) identify practices encouraging or hindering implementation and 3) produce recommendations for its dissemination. Methods: Twenty semi-structured interviews were conducted with caregivers from all three establishments. Results: The main factors associated with successful implementation were as follows: prescribers’ representations on patient education, considered of low value; on oral anticancer therapies, considered too dangerous to be handled by the patient him/herself, the indefinite legitimacy of certain professions in charge of patient education programs; patients’ engagement in their care pathway and provision of caregivers. Conclusion: Recommendations include developing patient education culture within the environment of the medical doctors’ curriculum, to consider contextual, pre-existing cooperative units for implementing patient education, to systematically send patients to patient education programs without practicing triage. Successful implementation of patient education critically depends on the prescribing physicians’ perceived value of patient education. Patient education should become mandatory, integrated as part of the cancer care pathway. Physicians lack the necessary time and/or means to assess patients’ capacity for engagement, without adequate strategies for their support. Therefore, physicians should systematically refer all patients to patient education, where nurses can tailor their coaching of cancer patients. Trial Registration: The study protocol was approved by the IRB SUD EST I (N° EudraCT: 2016-A00113-48). All participants were given written and verbal information about the study and gave informed consent to participate.
Investigation of a Non-isolated Reduced Redundant Power Processing DC/DC Converter for High-Power High Step-Up Applications

In this paper, a nonisolated high step-up dc/dc converter, belonging to the family of reduced redundant power processing converters (R2P2), is investigated for high-power applications. The selection of this topology as the most suitable for such applications among those belonging to the R2P2 family is justified. Emphasis is given on the theoretical analysis of the real step-up voltage ratio of the converter, and voltage and current stresses under continuous and discontinuous conduction modes of operation, taking into account the nonideality of the topology components, namely the parasitic resistances of semiconductor devices and inductors and the voltage drop of diodes. The theoretical analysis and the behavior of the selected converter are experimentally validated through a 2 kW prototype. Moreover, the overall efficiency of the chosen converter is experimentally investigated for various step-up voltage ratios and for a high-power range, considering a waste heat recovery system for a maritime application.
Mathematical Characteristics for the Automated Recognition of Musical Recordings

: - In this paper, a very efficient novel methodology for the automatic recognition of musical recordings is presented. The core of this system employs a set of mathematical characteristics, extracted from a musical recording, whose determination was based on human perception. For the automatic recognition realization a musical signal is sampled, similar features are extracted from it and they are compared with model ones, via proper comparison algorithms. Thus, automatic recognition of musical recordings that may have suffered a very high distortion of an arbitrary type is accomplished, with a considerable success rate.
Rhodium and its inorganic compounds

Rhodium 7440-16-6 Rh 102.91 Rhodium(III) chloride: Trihydrate 13569-65-8 RhCl3 · 3 H2O 263.32 Tetrahydrate no details RhCl3 · 4 H2O 281.33 Hydrate 20765-98-4 RhCl3 · x H2O – Anhydrate 10049-07-7 RhCl3 209.27 Rhodium(III) nitrate 10139-58-9 Rh(NO3)3 288.92 Rhodium(III) sulfate 10489-46-0 Rh2(SO4)3 493.99 Rhodium(II) acetate 5503-41-3 Rh(C2H3O2)2 220.99 Potassium pentachlororhodate(III) 65980-75-8 K2RhCl5 358.37 Sodium hexachlororhodate(III) 14972-70-4 Na3RhCl6 384.60 Ammonium hexachlororhodate(III) 15336-18-2 (NH4)3RhCl6 369.74 Chloropentaamine rhodium chloride(III) no details [Rh(NH3)5Cl]Cl2 294.42
HemiPhysio App: A smartwatch-based application for measuring upper limbs movement in children with Hemiparesis

—A smartwatch’s constant contact with the wrist provides opportunity to measure the differences in the movements of hands (upper limbs) in children with Hemiparetic Cerebral Palsy (CP) while performing daily physical activity (e.g., walking, eating). Children with Hemiparesis have significant weakness (spastic, contractures) on one side of the body that leads to impaired functions on that side. This paper gives the concept and design of a “HemiPhysio” app to collect the activity-related data of both upper limbs using sensors in a smartwatch. The machine learning models trained on collected data are then used to detect the impaired functions by the smartwatch. The child is then instructed for appropriate movement or correcting posture using alert or haptics. The HemiPhysio app should work for dynamic motion activities (e.g., walking) and for the static posture activities (e.g., eating), as well as the related upper limbs movements in these activities. The goal of our application is to encourage Hemiparetic children to use both hands during daily activities.
Malicious Tra�c classi�cation using Long Short-Term Memory (LSTM) model

Malicious traffic classification is the initial and primary step for any network-based security systems. This traffic classification systems include behavior-based anomaly detection system and Intrusion Detection System. Existing methods always relies on the conventional techniques and process the data in the fixed sequence, which may leads to performance issues. Furthermore, conventional techniques require proper annotation to process the volumetric data. Relying on the data annotation for efficient traffic classification may leads to network loops and bandwidth issues within the network. To address the above-mentioned issues, this paper presents a novel solution based on artificial intelligence perspective. The key idea of this paper is to propose a novel malicious classification system using Long Short-Term Memory (LSTM) model. To validate the efficiency of the proposed model, an experimental setup along with experimental validation is carried out. From the experimental results, it is proven that the proposed model is better in terms of accuracy, throughput when compared to the state-of-the-art models. Further, the accuracy of the proposed model outperforms the existing state of the art models with increase in 5% and overall 99.5% in accuracy.
T Cell Memory + Maintenance of CD8 Latent Virus Influences the Generation and

The inﬂuence of latent virus on CD8 (cid:1) T cell memory is poorly understood. HSV type 1 speciﬁcally establishes latency in trigeminal ganglia (TG) after corneal infection of mice. In latently infected TG, IL-15 deprivation reduced the following: 1) accumulation of HSV-speciﬁc CD8 (cid:1) effector T cells (HSV-CD8 eff ), 2) accumulation of CD127 (cid:1) putative HSV-CD8 memory precursors, and 3) the size and functionality of the memory (HSV-CD8 mem ) population. Although compromised in IL-15 (cid:2) / (cid:2) mice, the HSV-CD8 mem pool persisted in latently infected tissue, but not in noninfected tissue of the same mice. Anti-IL-2 treatment also dramatically reduced the size of the HSV-CD8 eff population in the TG, but did not inﬂuence the concomitant generation of the CD127 (cid:1) putative HSV-CD8 mem precursor population or the size or functionality of the HSV-CD8 mem pool. Thus, the size of the memory pool appears to be determined by the size of the CD127 (cid:1) CD8 mem precursor population and not by the size of the overall CD8 eff pool. HSV-CD8 mem showed a higher basal rate of proliferation in latently infected than noninfected tissue, which was associated with a reduced population of CD4 (cid:1) FoxP3 (cid:1) regulatory T cells. Thus, the generation, maintenance, and function of memory CD8 (cid:1) T cells is markedly inﬂuenced by latent virus. The Journal of Immunology, 2006, 177: 8356–8364.
THE ROLE OF SOME ANTIOXIDANTS ON ALLEVIATION THE HARMFUL EFFECTS OF SALINITY ON GROWTH AND YIELD OF WHEAT (Triticum aestivum L

Salt stress up to 11.5 dSm -1 impaired wheat growth by reducing shoot dry weight, shoot length, number of tillers, and leaf number per plant. Imposition of salt stress also had adverse effects on flag leaf nitrogen and phosphorous content and membrane stability index percentage, and yield as well as its components (spike length, number of spikelet per spike, grain number per spike, grain weight per spike and 100 grain weight), in addition quality of grains (carbohydrates, protein, phosphorous and potassium percentage). Application of both antioxidants increased significantly all growth and yield characteristics as well as improvement root structure. Moreover, salt induced reduction in growth and yield and its quality ameliorated by exogenously applied antioxidants, in particular, ascorbic acid (AsA) due to increasing all mentioned characters as compared to untreated plants under corresponding salinity level. Anatomically, increasing salinity levels decreased thickness of adventitious root, vascular cylinder, and thickness of either epidermis or metaxylem vessels. Treatment with either ascorbic acid or α-tocopherol at 100 mg/L and their interactions with salinity increased all the above mentioned parameters in both nonsalinized and salinized plants. Ascorbic acid is the most effective in this concern. to overcome destructive effect of salinity after 40 and 50 days from sowing.