Miracle-dz/UniFAR-FTUs huggingface dataset:
Long noncoding RNAs are critical regulators of pancreatic islet development and function

Long noncoding RNAs are critical regulators of pancreatic islet development and function Ruth A. Singer Diabetes is a complex group of metabolic disorders with genetic, immunological, and environmental etiologies. Decades of diabetes research have elucidated many genetic drivers of normal islet function and dysfunction. Furthermore, genome wide associated studies (GWAS) have discovered that most diabetes susceptibility loci fall outside of coding regions, which suggests a role for noncoding elements in the development of disease. This highlights our incomplete understanding of the islet regulome and suggests the need for detailed functional analyses of noncoding genes to precisely determine their contribution to diabetes susceptibility and disease progression. Transcriptome analyses have revealed that the eukaryotic genome is pervasively transcribed. Strikingly, only a small proportion of the transcriptome is subsequently translated into protein; the majority is made up non-protein coding RNAs (ncRNAs). The most abundant class of these ncRNAs are called long noncoding RNAs (lncRNAs), defined as transcripts longer than 200 nucleotides that lack protein-coding potential. The establishment of lncRNAs, once dismissed as genomic dark matter, as essential gene regulators in many biological processes has redefined the central role for RNA in cells. While evidence suggests a role for lncRNAs in islets and diabetes, in vivo functional characterization of islet lncRNAs is
randomized , double-blind noninferiority study of quadrivalent live attenuated nfluenza vaccine in adults

Background: Trivalent seasonal influenza vaccines contain 2 A strains and 1 B strain. B strains of 2 antigenically distinct lineages, Yamagata and Victoria, have been co-circulating annually, and the B strain included in vaccines often has not been a lineage match to the major circulating strain. Thus, a vaccine containing B strains from both lineages could broaden protection against influenza. Quadrivalent live attenuated influenza vaccine (Q/LAIV) is an investigational 4-strain formulation of LAIV that contains 2 A strains, A/H1N1 and A/H3N2, and 2 B strains, 1 from each lineage. Methods: A randomized, double-blind, active-controlled study of Q/LAIV was conducted in 1800 adults aged 18–49 years to compare the immunogenicity and safety of Q/LAIV to trivalent LAIV (T/LAIV). Subjects were randomized 4:1:1 to receive an intranasal dose of Q/LAIV (n = 1200) or 1 of 2 matching T/LAIV vaccines, each containing 1 of the B strains included in Q/LAIV (n = 600 total). The primary endpoint was the comparison of the post-vaccination strain-specific geometric mean titers (GMT) of hemagglutination inhibition antibody in Q/LAIV recipients to those in T/LAIV recipients, with immunologic noninferiority of Q/LAIV to be demonstrated if the upper bound of the 2-sided 95% confidence interval (CI) for the ratio of the GMTs [T/LAIV divided by Q/LAIV] was ≤1.5 for all strains. Results and Conclusion: Q/LAIV met the criteria for noninferiority: the ratios of the GMTs for the A/H1N1, A/H3N2, B/Yamagata, and B/Victoria strains were 1.09 (95% CI, 1.01–1.18), 1.05 (95% CI, 0.96–1.14), 1.10 (95% CI, 0.97–1.25), and 0.92 (95% CI, 0.82–1.03), respectively. Solicited symptoms and adverse events were similar in the Q/LAIV and T/LAIV arms. Q/LAIV may confer increased protection against influenza by targeting B strains from both lineages. © 2011 Elsevier Ltd. All rights reserved.
SPOR ORGANİZASYONLARINDA DESTİNASYON PAZARLAMASI İLE MEMNUNİYET ARASINDAKİ İLİŞKİNİN İNCELENMESİ: ANADOLU KUPASI YÜZME MÜSABAKALARINDA BİR ARAŞTIRMA THE RELATIONSHIP BETWEEN DESTINATION MARKETING AND SATISFACTION IN SPORT ORGANIZATIONS: A RESEARCH IN ANATOLIA CUP SWIMMING COMPETITIONS

The changes of consumer expectations and habits, required to destinations as a strategic evaluation and to be included to marketing process. This aspect of destination marketing are carried out by the way of different activities. The sport organizations that is a tool of destination marketing is playing an important role in this context. In this study it is aimed to investigate the relationship between the satisfaction and destination marketing in Anatolia Cup Swimming Competition organized in Isparta. In the study, 416 athletes, coaches, managers and referees which participated in organizations were surveyed. The results of study revealed that some of the dimensions of destination marketing such as contribution of organization to its surrounding, the city event performed, the structure of organization, accommodation-food and beverage companies have got a significant effect on satisfaction levels of participants.
Mobile Phone-Based Intervention in Hypertension Management

Hypertension is known as the major risk factor for cardiovascular mortality and morbidity. Antihypertensive agents are directed to prevent many of the harmful effects of elevated blood pressure, yet medication nonadherence hinders the effectiveness of these therapies. Nowadays the use of mobile phone has vastly spread among communities. The rapid adoption of smartphone technology creates a promising and interesting platform to overcome medication nonadherence. This review aimed to critically appraise whether mobile phone-based interventions are effective in increasing adherence in hypertensive patients. Literature searching was done in 3 databases: PubMed, Cochrane, and ProQuest. Findings were narrowed down using selection criteria. Relevant studies were to be critically appraised based on the guideline from Centre for Evidence-Based Medicine, Oxford University. We found that the reduction of blood pressure in participants who were given reminder through mobile phones was greater in comparison to control: systolic (94.4% vs 41.2%, p 0.003), diastolic (94.4% vs 76.5%, p0.04). Patients who were nonadherent at baseline benefit more from mobile phone-based intervention in comparison to adherent patients at baseline: RR 2.3 (95% CI: 1.4-4.4, p<0.001) vs RR 1.3 (95% CI: 1.0-1.6, p<0.05). In conclusion, mobile phone-based interventions were effective in increasing medication adherence in hypertensive patients. Clinical practice guidelines should consider this nonpharmacological method for a better blood pressure regulation.
Nuclear microsatellite and mitochondrial DNA analyses reveal the regional genetic structure and phylogeographical history of a sanguivorous land leech, Haemadipsa japonica, in Japan

Abstract Recent molecular studies have indicated that phylogeographical history of Japanese biota is likely shaped by geohistory along with biological events, such as distribution shifts, isolation, and divergence of populations. However, the genetic structure and phylogeographical history of terrestrial Annelida species, including leech species, are poorly understood. Therefore, we aimed to understand the genetic structure and phylogeographical history across the natural range of Haemadipsa japonica, a sanguivorous land leech species endemic to Japan, by using nine polymorphic nuclear microsatellites (nSSR) and cytochrome oxidase subunit one (COI) sequences of mitochondrial DNA (mtDNA). Analyses using nSSR revealed that H. japonica exhibited a stronger regional genetic differentiation among populations (G'ST = 0.77) than other animal species, probably because of the low mobility of land leech. Analyses using mtDNA indicated that H. japonica exhibited two distinct lineages (A and B), which were estimated to have diverged in the middle Pleistocene and probably because of range fragmentation resulting from climatic change and glacial and interglacial cycles. Lineage A was widely distributed across Japan, and lineage B was found in southwestern Japan. Analyses using nSSR revealed that lineage A was roughly divided into two population groups (i.e., northeastern and southwestern Japan); these analyses also revealed a gradual decrease in genetic diversity with increasing latitude in lineage A and a strong genetic drift in populations of northeastern Japan. Combined with the largely unresolved shallow polytomies from the mtDNA phylogeny, these results implied that lineage A may have undergone a rapid northward migration, probably during the Holocene. Then, the regional genetic structure with local unique gene pools may have been formed within each lineage because of the low mobility of this leech species.
Early optical detection of cerebral edema in vivo.

OBJECT Cerebral edema is a significant cause of morbidity and mortality in diverse disease states. Currently, the means to detect progressive cerebral edema in vivo includes the use of intracranial pressure (ICP) monitors and/or serial radiological studies. However, ICP measurements exhibit a high degree of variability, and ICP monitors detect edema only after it becomes sufficient to significantly raise ICP. The authors report the development of 2 distinct minimally invasive fiberoptic near-infrared (NIR) techniques able to directly detect early cerebral edema. METHODS Cytotoxic brain edema was induced in adult CD1 mice via water intoxication by intraperitoneal water administration (30% body weight intraperitoneally). An implantable dual-fiberoptic probe was stereotactically placed into the cerebral cortex and connected to optical source and detector hardware. Optical sources consisted of either broadband halogen illumination or a single-wavelength NIR laser diode, and the detector was a sensitive NIR spectrometer or optical power meter. In one subset of animals, a left-sided craniectomy was performed to obtain cortical biopsies for water-content determination to verify cerebral edema. In another subset of animals, an ICP transducer was placed on the contralateral cortex, which was synchronized to a computer and time stamped. RESULTS Using either broadband illumination with NIR spectroscopy or single-wavelength laser diode illumination with optical power meter detection, the authors detected a reduction in NIR optical reflectance during early cerebral edema. The time intervals between water injection (Time Point 0), optical trigger (defined as a 2-SD change in optical reflectance from baseline), and defined threshold ICP values of 10, 15 and 20 mm Hg were calculated. Reduction in NIR reflectance occurred significantly earlier than any of the ICP thresholds (p < 0.001). Saline-injected control mice exhibited a steady baseline optical signal. There was a significant correlation between reflectance change and tissue specific gravity of the cortical biopsies, further validating the dual-fiberoptic probe as a direct measure of cerebral edema. CONCLUSIONS Compared with traditional ICP monitoring, the aforementioned minimally invasive NIR techniques allow for the significantly earlier detection of cerebral edema, which may be of clinical utility in the identification and thus early treatment of cerebral edema.
Exploring the Needs of Patients Undergoing Hemodialysis: A Qualitative Study

Background: Many studies have focused on patients’ experiences living with hemodialysis therapy; however, there is little research exploring their needs. Therefore, the purpose of this study was to explore hemodialysis patients’ needs in Saudi Arabia. Methods: A qualitative research design with semi-structured interviews was used. Data were collected from Aghrass Medical Center, Jeddah, Saudi Arabia. Data were analyzed using thematic analysis. Results: A total of 16 hemodialysis patients underwent in-depth interviews. The mean age of the participants was 49 ± 14.93 years of age. More than half of the participants were male (56.25%), and most of them were married (75%). Regarding the clinical characteristics, all patients had three sessions in a week, and the average duration was four hours per session. The mean number of years on dialysis therapy was 3.80 ± 2.8. Using thematic analysis, four themes emerged. These were the impact of fatigue and need for fatigue self-management, need for family and social support, psychological and emotional support from healthcare professionals, and changes in the patients' role performance and their need for adaptation. Conclusions: This study highlights the aspects of needs among hemodialysis patients from their own perspective. Four themes of needs emerged from this study. Consequently, healthcare professionals should assess patients’ needs frequently to ensure high-quality care.
Robotic gait training in patients with cerebral palsy: a retrospective analysis

Objective: The present study sought to retrospectively evaluate the efficacy of robotic gait training in children with cerebral palsy (CP) gross motor function classification system (GMFCS) levels II, III and IV. Method: The medical records from 69 patients with CP, who participated in the Lokomat® protocol, were analyzed using a retrospective approach. The results from the Gross Motor Function Measure (GMFM), 6-minute walk test (6MinWT), 10-meter walk test (10MWT) and Timed Up and Go (TUG) test were analyzed before and after the protocol was administered. Results: An improvement in GMFM was observed for all GMFCS levels. GMFCS level III patients showed a significant improvement in the 6MinWT (p= 0.01), and GMFCS level IV patients displayed a significant improvement in GMFM dimension B (p= 0.03). All tests showed a significant improvement when compared to their performance before the application of the protocol. Conclusion: The study suggests that all patients diagnosed with CP benefit from gait training, using the Lokomat® system, within their expected motor frame.
CFD study of a horizontal axis wind turbine NREL Phase II

The present work aims to study the aerodynamic characteristics of the NREL phase II (generated only with S809 profile along the span for an untwisted case) rotor that is a horizontal axis downwind wind turbine rotor and which is assumed to stand isolated in the space. The two dimensional steady-incompressible flow Reynolds average NavierStokes equations, are solved by using the commercial CFD package Ansys Fluent. The 2D computations are first performed on S809 airfoil in order to define the most suitable model to be used; the turbulence closure model has been chosen among four possible candidates (standard , Spalart-Allmaras, based on comparison of pressure coefficient for the different configurations with experimental results. Secondly, through a three dimensional study we tried to simulate the experiment for wind speed velocities of 7.2, 10.56, 12.85, 16.3, and 9.18m/s. Results of pressure and torque for considered wind turbine rotor have been directly compared to the available experimental data. The comparisons show that CFD results along with the turbulence model used can predict the span-wise loading of the wind turbine rotor with reasonable agreement. The work presented here is the first stage of project that aims at giving a better understanding of the main influence of the rotational effect on boundary layer separation, and identify the stalled configuration in order to control this latter in future work.
Adjuvant effect of inhaled particulate matter containing free radicals following house-dust mite induction of asthma in mice

Abstract Introduction Exposures to particulate matter (PM) from combustion sources can exacerbate preexisting asthma. However, the cellular and molecular mechanisms by which PM promotes the exacerbation of asthma remain elusive. We used a house dust mite (HDM)-induced mouse model of asthma to test the hypothesis that inhaled DCB230, which are PM containing environmentally persistent free radicals (EPFRs), will aggravate asthmatic responses. Methods Groups of 8–10-week-old C57BL/6 male mice were exposed to either air or DCB230 aerosols at a concentration of 1.5 mg/m3 4 h/day for 10 days with or without prior HDM-induction of asthma. Results Aerosolized DCB230 particles formed small aggregates (30–150 nm). Mice exposed to DCB230 alone showed significantly reduced lung tidal volume, overexpression of the Muc5ac gene, and dysregulation of 4 inflammation related genes, Ccl11, Ccl24, Il-10, and Tpsb2. This suggests DCB230 particles interacted with the lung epithelium inducing mucous hypersecretion and restricting lung volume. In addition to reduced lung tidal volume, compared to respective controls, the HDM + DCB230-exposed group exhibited significantly increased lung tissue damping and up-regulated expression of Muc5ac, indicating that in this model, mucous hypersecretion may be central to pulmonary dysfunction. This group also showed augmented lung eosinophilic inflammation accompanied by an up-regulation of 36 asthma related genes. Twelve of these genes are part of IL-17 signaling, suggesting that this pathway is critical for DCB230 induced toxicity and adjuvant effects in lungs previously exposed to HDM. Conclusion Our data indicate that inhaled DCB230 can act as an adjuvant, exacerbating asthma through IL-17-mediated responses in a HDM mouse model.
Distributions of Downwelling Radiance at 10 and 20 μm in the High Arctic

Abstract In the Arctic, most of the infrared (IR) energy emitted by the surface escapes to space in two atmospheric windows centred at 10 and 20 μm. As the Arctic warms and its water vapour burden increases, the 20 μm cooling-to-space window, in particular, is expected to become increasingly opaque (or “closed”), trapping more IR radiation, with implications for the Arctic’s radiative energy balance. Since 2006, the Canadian Network for the Detection of Atmospheric Change has measured downwelling IR radiation with Atmospheric Emitted Radiance Interferometers at the Polar Environment Atmospheric Research Laboratory at Eureka, Canada, providing measurements of the 10 and 20 μm windows in the High Arctic. In this work, measurements of the distribution of downwelling 10 and 20 µm brightness temperatures at Eureka are separated based on cloud cover, providing a comparison to an existing 10 µm climatology from the Southern Great Plains. The downwelling radiance at both 10 and 20 μm exhibits strong seasonal variability as a result of changes in cloud cover, temperature, and water vapour. Given the 20 µm window’s limited transparency, its ability to allow surface IR radiation to escape to space is found to be highly sensitive to changes in atmospheric water vapour and temperature. When separated by season, brightness temperatures in the 20 µm window are independent of cloud optical thickness in the summer, indicating that this window is opaque in the summer. This may have long-term consequences, particularly as warmer temperatures and increased water vapour “close” the 20 μm window for a prolonged period each year.
DETERMINANT OF GOOD CORPORATE GOVERNANCE AND FREE CASH FLOW EFFECT ON EARNING MANAGEMENT

Tujuan Penelitian ini adalah untuk mengetahui Pengaruh Ukuran Komite Audit, Proporsi Dewan Komisaris Independen, Kepemilikan Institusional, Kepemilikan Manajerial, dan Free Cash Flow baik secara simultan maupun parsial terhadap Manajemen Laba. Data yang digunakan adalah sumber yang telah ada baik data internal maupun eksternal dan data dapat diakses melalui internet dan publikasi informasi. Data yang digunakan yaitu laporan keuangan perusahaan manufaktur periode 2018-2020. Metode analisis data menggunakan regresi linear berganda. Hasil penelitian menunjukkan bahwa Kepemilikan Institusional berpengaruh positif secara signifikan terhadap Manajemen Laba, Free Cash Flow berpengaruh negatif terhadap Manajemen Laba. Sedangkan, Ukuran Komite Audit, Proporsi Dewan Komisaris Independen, dan Kepemilikan Manajerial tidak berpengaruh terhadap Manajemen Laba
Macrophage Heterogeneity and Its Impact on Myocardial Ischemia-Reperfusion Injury: An Integrative Review

Abstract The coronary reperfusion following acute myocardial infarction can paradoxically trigger myocardial ischemia-reperfusion (IR) injury. This complex phenomenon involves the intricate interplay of different subsets of macrophages. These macrophages are crucial players in the post-infarction inflammatory response and subsequent myocardial anti-inflammatory repair. However, their diverse functions can lead to both beneficial and detrimental effects. On one hand, these macrophages play a crucial role in orchestrating the inflammatory response, aiding in the clearance of cellular debris and initiating tissue repair mechanisms. On the other hand, their excessive infiltration and activation can contribute to the perpetuation of the inflammatory cascade, leading to additional myocardial injury and adverse cardiac remodeling. Multiple mechanisms contribute to the IR injury mediated by macrophages, including oxidative stress, apoptosis, and autophagy. These processes further exacerbate the damage to the already vulnerable myocardial tissue. To address this delicate balance, therapeutic strategies aiming to target and modulate macrophage polarization and function are being explored. By fine-tuning the immune inflammatory response, such interventions hold promise in mitigating post-infarction myocardial injury and fostering a more favorable environment for myocardial healing and recovery. Through advancements in this area of research, potential anti-inflammatory interventions may pave the way for improved clinical outcomes and better management of patients after acute myocardial infarction.
Mortality patterns of patients with tonsillar squamous cell carcinoma: a population-based study

Objective Tonsillar squamous cell carcinoma (TSCC) and second primary malignancies (SPMs) are the most common causes of mortality in patients with primary TSCC. However, the competing data on TSCC-specific death (TSD) or SPM-related death in patients with TSCC have not been evaluated. This study aimed to analyze the mortality patterns and formulate prediction models of mortality risk caused by TSCC and SPMs. Methods Data on patients with a first diagnosis of TSCC were extracted as the training cohort from the 18 registries comprising the Surveillance, Epidemiology, and End Results (SEER) database. A competing risk approach of cumulation incidence function was used to estimate cumulative incidence curves. Fine and gray proportional sub-distributed hazard model analyses were performed to investigate the risk factors of TSD and SPMs. A nomogram was developed to predict the 5- and 10-year risk probabilities of death caused by TSCC and SPMs. Moreover, data from the 22 registries of the SEER database were also extracted to validate the nomograms. Results In the training cohort, we identified 14,530 patients with primary TSCC, with TSCC (46.84%) as the leading cause of death, followed by SPMs (26.86%) among all causes of death. In the proportion of SPMs, the lungs and bronchus (22.64%) were the most common sites for SPM-related deaths, followed by the larynx (9.99%), esophagus (8.46%), and Non-Melanoma skin (6.82%). Multivariate competing risk model showed that age, ethnicity, marital status, primary site, summary stage, radiotherapy, and surgery were independently associated with mortality caused by TSCC and SPMs. Such risk factors were selected to formulate prognostic nomograms. The nomograms showed preferable discrimination and calibration in both the training and validation cohorts. Conclusion Patients with primary TSCC have a high mortality risk of SPMs, and the competing risk nomogram has an ideal performance for predicting TSD and SPMs-related mortality. Routine follow-up care for TSCC survivors should be expanded to monitor SPMs.