Miracle-dz/UniFAR-FTUs huggingface dataset:
Connection Level Stability Analysis of the Internet using the Sum of Squares Technique

We study connection-level models of file transfer requests in the Internet, where connection arrivals to each route occur according to Poisson processes and the file-sizes have phase-type distributions. We investigate the use of the Sum-of-Squares (SoS) technique to construct Lyapunov functions that satisfy Foster’s condition for stochastic stability. The methodology is used to numerically establish the connection-level stability of linear and star network topologies when the load on each link is less than its capacity.
06 489-498 Son

Multivariate statistical methods were employed to examine sexual dimorphism in size and shape of Nucella lapillus collected from 16 sheltered sites along coasts of Anglesey and the Lleyn Peninsula, North Wales, UK. Females were significantly larger than males in overall size; among 12 relative measures of shell shape, two ratios (shell width/shell length and aperture length/shell length) were significantly different between males and females, but these differences usually decreased with increasing age (shell length). The observed hypoallometric dimorphism could be a result of selection on increased female fecundity, which may be positively correlated with shell size in N. lapillus as in other gastropod species.
Integration theories and self-rating : the application of cognitive algebra to schema theory

An experiment was conducted to investigate the appropriateness of Anderson's (1981) averaging integration model to self-rating. This model would enable simultaneous estimation of the extremity (or position) and importance (or weight) of those self-schemata involved in a given rating task (Markus, 1977). It was hypothesised that the averaging model of integration could be described geometrically as predictive of a "city-block" metric, such that estimates of proximity (self-descriptiveness of adjective-qualifier pairs) consist of summed estimates of the proximities of each component of the stimulus item to a constant comparitor point. Geometrically, this model therefore predicts that movement through the space in which rating takes place is horizontal and vertical, but never diagonal. This model is contrasted with a euclidean metric in which ratings are predicted from the square root of the summed squared proximities. Stimulus items consisted of pairs of adjectives, each qualified by one of six adverbs.There were two Adjective Type conditions (Abstract, Concrete) and three Instructional Sets, yielding a 6 (qualifier of first adjective) X 6 (qualifier of second adjective) X 2 (adjective type) within-subject factorial design with Instructional Set as a between groups factor. Data were visual-analog ratings from 0 (not at all like me) to 100 (exactly like me). These were subject to a range of model fitting procedures intended to 'identify convergence with the averaging and euclidean models, including Median Polish (Tukey, 1975), IMSL iteration procedures, and residuals ANOVA (Anderson, 1982). Results indicate that neither the averaging nor the euclidean models satifactorally predicted the ratings obtained, as the data departs significantly from each. Of the two models, however, the euclidean model shows superior fit to the data. It is suggested that the results may be consistent with a differential-weight averaging model (Anderson, 1982), although evidence to his conclusion is secondary.
Efficacy, safety and tolerability of pregabalin treatment of painful diabetic peripheral neuropathy: findings from 7 randomized, controlled trials across a range of doses

OBJECTIVE ― to evaluate the efficacy, safety, and tolerability of pregabalin across the effective dosing range; to determine differences in the efficacy of TID and BID dosage schedules; and to use time to event analysis to determine the time to onset of a sustained therapeutic effect using data from 7 trials of pregabalin in painful diabetic neuropathy (DPN). METHODS ― Data were pooled across 7 double-blind, randomized, placebo-controlled trials using pregabalin to treat painful DPN with dosages of 150, 300, and 600 mg/d, administered TID or BID. Only 1 trial included all 3 of these dosages and TID dosing was used in 4. All studies shared fundamental selection criteria and treatment durations ranged from 5-13 weeks. RESULTS ― pooled analysis showed pregabalin significantly reduced pain and pain-related sleep interference associated with DPN (150, 300 and 600 mg/d administered TID vs placebo all P ≤ 0.007). Only the 600 mg/d dosage showed efficacy when administered BID ( P ≤ 0.001). Pain and sleep interference reductions associated with pregabalin appear to be positively correlated with dosage; the greatest effect was observed in patients treated with 600 mg/d. Kaplan-Meier analysis revealed the median time to onset of a sustained ( ≥ 30% at end-point) 1-point improvement was 4 days in patients treated with pregabalin 600 mg/d; 5 days in patients treated with pregabalin 300 mg/d; 13 days in patients receiving pregabalin 150 mg/d; and 60 days in patients receiving placebo. The most common treatment-emergent adverse events were dizziness, somnolence and peripheral edema.
ANTICANCER, ANTIMICROBIAL AND ANTIOXIDANT BIOACTIVE FACTORS DERIVED FROM MARINE FUNGAL ENDOPHYTES; A REVIEW

The marine-derived fungi has proven to be a very rich source of extremely potent compounds that have demonstrated a number of biologically active compounds with varying degrees of action such as anticancer, antioxidant, anti proliferative and anti microbial properties. These compounds are of interest as new lead structures for medicine as well as for plant and animal self defense. This review is an attempt to consolidate the latest studies in this field, and to showcase the immense competence of marine microbial flora and fauna as bioactive metabolite producers. Liu and co-workers evaluated the antioxidant activity of an endophytic Xylaria . isolated from the medicinal plant Ginkgo biloba(88) . The results collected indicated that the methanol antioxidant capacity due to the presence of “phenolics” and “flavonoids” compounds among 41identified compounds. Huang and coworkers investigated the antioxidant capacities of endophytic fungal cultures of medicinal Chinese plants and its correlation to their total phenolic contents. They suggested that the phenolic content were the major antioxidant constituents of the endophytes (89).
Species Pattern Analysis in Long-Term Ecological Data Using Statistical and Biclustering Approach

—Analyzing long-term ecological data and appropriate visualization techniques are important for understanding biodiversity mechanisms and predicting effects of environmental changes. In this study, we applied an unconventional approach of finding species pattern, the tendency of species abundance monthly and annually in long-term ecological data, by using statistical and biclustering methods. We tended to find out the similarity between each species after summarizing long-term dataset, and then visualized a correlation matrix and network, which exhibit significant statistical association with each other. For detecting species sets frequently appearing together or showing similar variation in abundance, we also employed a clustering based association mining. For experiments, we used weekly abundance butterfly data from the Environmental Change Network (ECN) in the UK. We could find out how often sets of species show the repeated pattern in long-term species abundance data. The approaches we have described can enable researchers to gain insight of many other relationships like between various species and environmental factors. In addition, combining our methods with detailed analyses or assumptions, such as genetic associations between species and functional subsystems may especially be effective in further analysis.
Ligand Independent Activation of VEGF Receptor 2 by Fluid Shear Stress Regulates Activation of Endothelial Nitric Oxide Synthase

—Fluid shear stress generated by blood flowing over the endothelium is a major determinant of arterial tone, vascular remodeling, and atherogenesis. Nitric oxide (NO) produced by endothelial NO synthase (eNOS) plays an essential role in regulation of vascular function and structure by blood flow, but the molecular mechanisms that transduce mechanical force to eNOS activation are not well understood. In this study, we found that laminar flow (shear stress 5 12 dyne/cm 2 ) rapidly activates vascular endothelial growth factor receptor 2 (VEGFR2) in a ligand-independent manner and leads to eNOS activation in cultured endothelial cells. Flow-stimulated VEGFR2 recruits phosphoinositide 3-kinase and mediates activation of Akt and eNOS. Inhibiting VEGFR2 kinase with selective inhibitors blocks flow-induced activation of Akt and eNOS and production of NO. Decreasing VEGFR2 expression with antisense VEGFR2 oligonucleotides significantly attenuates activation of Akt and eNOS. Furthermore, Src kinases are involved in flow-stimulated VEGFR2 because inhibiting Src kinases by PP2, a selective inhibitor for Src kinases, abolishes flow-induced VEGFR2 tyrosine phosphorylation and downstream signaling. Finally, we show that inhibiting VEGFR2 kinase significantly reduces flow-mediated NO-dependent arteriolar dilation in vivo. These data identify VEGFR2 as a key mechanotransducer that activates eNOS in response to blood flow. ( Circ Res . 2003;93: lll - lll .) anti–phospho-p44/42MAPK Cell Signaling Technologies. monoclo-nal from Transduction Laboratories. 4G10 Upstate polyclonal
Verbal fluency tests assess global cognitive status but have limited diagnostic differentiation: evidence from a large-scale examination of six neurodegenerative diseases

Objective: Verbal fluency is clinically widely used but its utility in differentiating between neurodegenerative dementias and progressive aphasias, and from healthy controls, remains unclear. We assessed whether the total number of words produced, their psycholinguistic properties, and production order effects could differentiate between Alzheimer's disease (AD), behavioural variant of frontotemporal dementia (bvFTD), non-fluent and semantic variants of primary progressive aphasia (PPA), progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and healthy controls. Methods: Category and letter fluency tasks were administered to 33 controls and 139 patients at their baseline clinical visit: 18 AD, 16 bvFTD, 26 nfvPPA, 26 svPPA, 36 PSP, and 17 CBS. We assessed group differences for total words, psycholinguistic word properties, and associations between production order and exemplar psycholinguistic properties. Receiver Operating Characteristic (ROC) curves determined which measure could best discriminate patient groups and controls. Results: Total word count distinguished controls from all patient groups, but neither this measure nor the word properties differentiated the patient groups. ROC curves revealed that, when comparing controls to patients, the strongest discriminators were total word count followed by word frequency. Word frequency was the strongest discriminator for svPPA versus other groups. Fluency word counts were associated with global severity as measured by Addenbrooke's Cognitive Examination-Revised (ACE-R). Conclusions: Verbal fluency is an efficient test for assessing global brain-cognitive health but has limited utility in differentiating between cognitively- and anatomically-disparate patient groups. This outcome is consistent with the fact that verbal fluency requires many different aspects of higher cognition and language.
Modular Equations and Discrete, Genus-Zero Subgroups of SL(2, ℝ) Containing Γ(N)

Abstract Let $G$ be a discrete subgroup of $\text{SL}\left( 2,\,\mathbb{R} \right)$ which contains $\Gamma \left( N \right)$ for some $N$ . If the genus of $X\left( G \right)$ is zero, then there is a unique normalised generator of the field of $G$ -automorphic functions which is known as a normalised Hauptmodul. This paper gives a characterisation of normalised Hauptmoduls as formal $q$ series using modular polynomials.
Changes in Plaque Composition and the Pleiotropic Effects of€Statins

Optimal ICD programming, which focuses on the reduction of therapies, could be a safe and effective strategy in preventing subsequent morbidity and/or mortality from ICD shocks (5), but the effect on outcomes remains to be determined in the setting of ESs. We acknowledge that information regarding the type of appropriate therapies (antitachycardia pacing or shock) and the use of catheter ablation of VT could have been useful. Furthermore, events were not centrally adjudicated. These were significant limitations because these data could have possibly affected interpretation of the clinical outcomes. In conclusion, our findings suggest that ESs are rare events in primary prevention ICD recipients (approximately 1%), are more likely to occur among men, in patients with renal failure and particularly in those with a low ejection fraction. ESs are independently associated with poor outcomes.
Transmission of Pandemic H1N1 Inﬂuenza Virus and Impact of Prior Exposure to Seasonal Strains or Interferon Treatment (cid:1)

Novel swine-origin inﬂuenza viruses of the H1N1 subtype were ﬁrst detected in humans in April 2009. As of 12 August 2009, 180,000 cases had been reported globally. Despite the fact that they are of the same antigenic subtype as seasonal inﬂuenza viruses circulating in humans since 1977, these viruses continue to spread and have caused the ﬁrst inﬂuenza pandemic since 1968. Here we show that a pandemic H1N1 strain replicates in and transmits among guinea pigs with similar efﬁciency to that of a seasonal H3N2 inﬂuenza virus. This transmission was, however, partially disrupted when guinea pigs had preexisting immunity to recent human isolates of either the H1N1 or H3N2 subtype and was fully blocked through daily intranasal administration of interferon to either inoculated or exposed animals. Our results suggest that partial immunity resulting from prior exposure to conventional human strains may blunt the impact of pandemic H1N1 viruses in the human population. In addition, the use of interferon as an antiviral prophylaxis may be an effective way to limit spread in at-risk populations.
SCREENING AND DETECTION OF ALPHA AMYLASE INHIBITORS PRODUCED BY MARINE MICROORGANISMS BY MODIFIED TLC AND RPTLC METHODS

Screening and detection of marine actinomycetes producing alpha amylase inhibitor was carried out by modified TLC plate method and new RPTLC plate method respectively. Out of 200 isolates only one α-amylase inhibitor producing strain was isolated from the marine sediment collected from Tamilnadu coast of Bay of Bengal. The strain showed some similarities with strain Streptomyces lateritius like antibiotic production and similar sporophore formation. However, more differences were observed with respect to carbon sources utilization, hence it was designated as Streptomyces lateritius var TP4/6. This paper involves development of modified TLC and RPTLC method for screening of proteinaceous amylase inhibitors. These methods are more reliable than existing methods like starch plate, starch agar plate and TLC plate method for primary screening of alpha amylase inhibitors. Our strain TP4/6 characteristics were compared with the existed strain Streptomyces lateritius and concluded that it is a variety of the existed one. This was the first report on screening and detection of proteinaceous
STARTUP FOR OPERATING A SOLID CELL BASED ON TRANSIENT ANALYSES

In this paper, conservations of charge, mass, and energy are implemented to establish the basic relationship between voltage and current as well as the mathematical model for investigating the transient behavior of a planar SOPC. Typical response time and temperature ramp rate of the SOFC under steady operating conditions are calculated first and ascend with increasing current density. Furthermore, transient behavior is investigated by setting a series of step functions of current density to simulate various startup operating modes. To avoid the temperature ramp rate being too high during the startup period, stepwise increment of the current density seems to be more suitable. For example, the three-step increment series of 300 mA/cm2, 500 mA/cm2 and 640 mA/cm2 would result in a temperature ramp rate complied with a given specification, e.g., less than 5°C per minute, while the total response time is in a moderate range as well. work established a mathematical model, including electrochemical reactions and heat transfer phenomena in the active area of an SOFC, and performed transient analyses for optimizing the operating conditions in the startup stage. It is shown that the average temperature increment rate during the startup stage of SOFCs can be modulated by imposing a series of step functions of current density to simulate various startup operating modes. The outcome of this work provides a simple and practical calculation procedure for investigating the transient behaviors of SOFCs, which can offer the necessary design database for prototyping integrated system applications.
inBALB/cmice following intranasal challengewithviable enterotoxigenicEscherichia coli

The immunogenicity induced in BALB/c mice following intranasal challenge with a viable nonlethal dose (1.2 10 CFU) of enterotoxigenic Escherichia coli (ETEC) strain E23477A (O139:H28:CS1:CS3:LT:ST) was studied over a 140-day period. Serum IgG and IgM antibodies against coli surface antigen 3 (CS3), O139 lipopolysaccharide and heat-labile enterotoxin were measured by day 14 and remained at elevated levels out to day 140. The serum IgG response to the somatic antigens (CS3 and O139 lipopolysaccharide) was significantly greater (Po 0.05) than the IgG response to heat-labile enterotoxin, and the serum IgG response to CS3 was significantly greater (Po 0.05) than the IgG response to O139 lipopolysaccharide. The predominant serum IgG subclasses to CS3 were IgG1 and IgG2a, and they were significantly greater (Po 0.05) than IgG2b and IgG3. The predominant serum IgG subclass response to O139 lipopolysaccharide was initially IgG3 until day 56, after which IgG1 was predominant. The serum subclass response to CS3 indicated a mixed T helper 1/2 (Th1/Th2) profile, whereas the response to O139 lipopolysaccharide was primarily that of a Th2-type, at least over time. Fecal IgG and IgA responses to CS3 and O139 lipopolysaccharide were detected by day 14 and were measured out to day 140, with the CS3 fecal antibody responses being significantly greater (Po 0.05) than the O139 lipopolysaccharide and heat-labile enterotoxin fecal antibody responses. The aim of this study is the development of the intranasal mouse model that can aid in better understanding the immunopathology of ETEC infection and in screening of vaccine candidates prior to volunteer trials.
OBO EDIT: A TOOL FOR CLASSIFING THE BIOLOGICAL DATA

Classification of the huge amount of information got more attention since the concept semantic web developed. The sharing of information between people and application efficiently is an important concern of last few decade. Many classification techniques like taxonomy, keyword, thesaurus, data model and ontology exist to classify and defining different biological concepts. To avoid replication and provide conceptual, syntactic and semantic view of data computer scientists adopt ‘ontology’ for classification. Open Biomedical Ontology Editor (OBO-Editor) is a tool that provides a common platform to share different biomedical and biological information under an umbrella.
Efﬁcient Infection of a Human B Cell Line with Cell-Free Kaposi’s Sarcoma-Associated Herpesvirus

Kaposi’s sarcoma-associated herpesvirus (KSHV) is causatively linked to two B cell lymphoproliferative disorders, multicentric Castleman’s disease and primary effusion lymphoma. Latently infected B cells are a major KSHV reservoir, and virus activation from tonsillar B cells can result in salivary shedding and virus transmission. Paradoxically, human B cells (primary and continuous) are notoriously refractory to infection, thus posing a major obstacle to the study of KSHV in this cell type. By performing a strategic search of human B cell lymphoma lines, we found that MC116 cells were efﬁciently infected by cell-free KSHV. Upon exposure to recombinant KSHV.219, enhanced green ﬂuorescent protein reporter expression was detected in 17 to 20% of MC116 cells. Latent-phase transcription and protein synthesis were detected by reverse transcription-PCR and detection of la-tency-associated nuclear antigen expression, respectively, in cell lysates and individual cells. Selection based on the puromycin resistance gene in KSHV.219 yielded cultures with all cells infected. After repeated passaging of the selected KSHV-infected cells without puromycin, latent KSHV was maintained in a small fraction of cells. Infected MC116 cells could be induced into lytic phase with histone deacetylase inhibitors, as is known for latently infected non-B cell lines, and also selectively by the B cell-spe-ciﬁc pathway involving B cell receptor cross-linking. Lytic-phase transition was documented by red ﬂuorescent protein reporter expression, late structural glycoprotein (K8.1A, gH) detection, and infectious KSHV
The Actin Side-binding Domain of Gelsolin Also Caps Actin Filaments FOR

Gelsolin is an actin filament-severing and -capping protein which is inhibited by polyphosphoinositides (PPI). Severing requires gelsolin binding to the side of the filaments through a site in segments 2 and 3 (52-3) to position another site in segment 1 (Sl) to sever filaments. In this paper, we report that 52-3, like S1, caps actin filaments. Since neither S1 and 52-3 caps as well as gelsolin, and neither severs actin filament, S2-3 may ac- tively contribute to severing by capping filaments coop-eratively with S1. We used deletional mutagenesis to 10-cate the S2-3 sequence required for actin filament side binding, capping, and PPI binding and found that these sites are located close to the NH, terminus of 52 (resi-dues 161-172). S3, a segment which has no known func- tion up to now and does not by itself bind actin, contrib-utes to stable capping and may contain an additional PPI-binding site.
A Log-Tool Suite for Embedded Systems

—Logging is a common method to monitor the operation of a system and to identify failures of services and system components. When developing software for an embedded system there are stricter restrictions that result from the limited hardware resources. The performance of the hardware as well as the available memory is limited. Furthermore, embedded systems are often not accessible for a long period of time. This paper presents tools to improve existing logging methods without compromising existing development ﬂows. Essentially, these tools on one hand transparently pre-process the source code in order to optimize logging instructions and add on the other hand a post-processing step when analyzing log-ﬁles. The presented tools were evaluated by integrating them to an industrial project where they show a signiﬁcant improvement of the logging performance.
GESTIÓN DE PROYECTOS DE SOFTWARE PARA INSTITUCIONES PÚBLICAS

This paper presents an approach to manage aspect related to software projects for public administration under the notion of service providers, following Venezuela state laws and government lines. The nation is particularly interested in free Fecha de Recepción del Artículo: 20 de Octubre de 2006 Fecha de Aceptación del Artículo 4 de Diciembre de 2006 Artículo