Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect Of Content Development On Android Applications On Knowledge Of Dietary Prescriptions On Metabolic Syndrome Risk

Metabolic syndrome is generally defined as meeting 3 (three) of 5 (five) criteria including abdominal obesity, hypertriglyceridemia, low HDL (high density lipoprotein) cholesterol, hypertension and hyperglycemia. About 20-25% of the world's adult population has the metabolic syndrome. The purpose of this study was to determine the effect of the android application on knowledge of dietary prescriptions in the community at risk for metabolic syndrome. The research design is a quasi-experimental study (quasi-experimental study), with a non-randomized control group pre-test - post-test test design that aims to determine the possibility of a causal relationship by intervening or giving treatment to one or more experimental groups, then the results (effect) of intervention was compared with a group that was subjected to different treatments (control group). Characteristics of age (p=0.172), gender (p=0.25) and education (p=0.055). Knowledge before intervention p=0,306 and after intervention p=0,009 in both groups. Knowledge before and after intervention in the case group p=0.0005 and knowledge before and after intervention in the control group p=0.0005. The types of outputs produced in this study are application systems for early detection of metabolic syndrome disease and dietary prescriptions, intellectual property rights and research journal articles. Introducing this android application so that it can be better known to the public in general and developing this android application so that it becomes more interesting and easy to understand.
University of Birmingham Random matrix-based dimensionality reduction for bioluminescence tomography reconstruction

We show how a random matrix can be used to reduce the dimensionality of the bioluminescence tomography reconstruction problem. A randomised low-rank approximation for the sensitivity matrix is computed, and we show how this can be used to reconstruct the bioluminescence source distribution on a randomised basis for the mesh nodes. The distribution on the original mesh can be found easily via a simple matrix multiplication. The majority of the computation required can be performed in advance of the reconstruction, and the reconstruction time itself is of the order milliseconds. This could allow for high frame rate real-time reconstructions to be performed.
Numerical Simulation of Separated Flows

A new numerical method, based on the Vortex Method, for the simulation of two-dimensional separated flows, was developed and tested on a wide range of gases. The fluid is incompressible and the Reynolds number is high. A rigorous analytical basis for the representation of the Navier-Stokes equation in terms of the vorticity is used. An equation for the control of circulation around each body is included. An inviscid outer flow (computed by the Vortex Method) was coupled with a viscous boundary layer flow (computed by an Eulerian method). This version of the Vortex Method treats bodies of arbitrary shape, and accurately computes the pressure and shear stress at the solid boundary. These two quantities reflect the structure of the boundary layer. Several versions of the method are presented and applied to various problems, most of which have massive separation. Comparison of its results with other results, generally experimental, demonstrates the reliability and the general accuracy of the new method, with little dependence on empirical parameters. Many of the complex features of the flow past a circular cylinder, over a wide range of Reynolds numbers, are correctly reproduced.
Evaluation of primers for the detection of deadwood-inhabiting archaea via amplicon sequencing

Archaea have been reported from deadwood of a few different tree species in temperate and boreal forest ecosystems in the past. However, while one of their functions is well linked to methane production any additional contribution to wood decomposition is not understood and underexplored which may be also attributed to lacking investigations on their diversity in this substrate. With this current work, we aim at encouraging further investigations by providing aid in primer choice for DNA metabarcoding using Illumina amplicon sequencing. We tested 16S primer pairs on genomic DNA extracted from woody tissue of four temperate deciduous tree species. Three primer pairs were specific to archaea and one prokaryotic primer pair theoretically amplifies both, bacterial and archaeal DNA. Methanobacteriales and Methanomassiliicoccales have been consistently identified as dominant orders across all datasets but significant variability in ASV richness was observed using different primer combinations. Nitrososphaerales have only been identified when using archaea-specific primer sets. In addition, the most commonly applied primer combination targeting prokaryotes in general yielded the lowest relative proportion of archaeal sequences per sample, which underlines the fact, that using target specific primers unraveled a yet unknown diversity of archaea in deadwood. Hence, archaea seem to be an important group of the deadwood-inhabiting community and further research is needed to explore their role during the decomposition process.
Dijagnoza Brugada sindroma na temelju konfiguracije signala električne aktivnosti srca

U ovom radu su prikazani postupci dijagnosticiranja i klasificiranja bolesti srca, koja se naziva Brugada sindrom, na temelju konfiguracije signala električne aktivnosti srca. Prikazi signala akcijskog potencijala srca i signala elektrokardiograma u obliku krivulja pružaju informacije o pravilnosti ili nepravilnosti električne srčane aktivnosti odnosno o pravilnom ili nepravilnom radu srčanog mišića. Kako je elektrokardiogram najpouzdaniji alat za dijagnosticiranje i klasifikaciju ovog sindroma, opisani su para-metri tj. konfiguracije elektrokardiograma na temelju kojih se otkriva Brugada sindrom i klasificiraju definirani tipovi tog sindroma. Razumijevanje poveznica Brugada sindroma i parametara elektrokardiogramskog signala pomaže liječnicima da lakše upoznaju i shvate Brugada sindrom, što je veoma značajno za dijagnosticiranje, ali i za postupak terapije i liječenja ove bolesti.
Design of a wide field-of-view, compact head-mounted display based on free-form prisms tiling

With the advent of high brightness microdisplay, augmented reality head mounted display (AR-HMD) has rapidly developed and applied. Various optical schemes emerge one after another. However, it is still a huge challenge to realize large field of view (FOV), high resolution and keep the compact form of head mounted display. We propose a novel free-form prism tiling optical system, which can simultaneously realize large field of view, high resolution and compact optical see-through augmented reality HMD. It can overcome the FOV/resolution invariant and solves the problem that the optical axes of the display channels don’t coincide with the visual axis of the human eye. The optical system consists of two microdisplays, two free-form prisms and a compensation lens which are attached together. The prisms are partially overlapped to provide the same field of view and reduce the seam at the transition region of adjacent FOV. The optical see-through system we designed achieves large FOV of 52.8°×52.8° (70° diagonally) and resolution of 33.7 pixels/degree, and has good optical performance. We emulated the system with distortion and illuminance pre-conditioning and discussed the remaining problems and future work.
Resolving the Inner Cavity of the HD 100546 Disk: A Candidate Young Planetary System?

The inner 100 AU of HD 100546 is studied via far-ultraviolet long-slit spectroscopy with the Hubble Space Telescope Space Telescope Imaging Spectrograph (STIS). The star is surrounded by reflection nebulosity, which can be traced 100 AU in the continuum, and by emission from H I Lyα, N I, Si II, and fluorescent H2 transitions. The Lyα emission can be traced up to 200 AU along the system semimajor axis and 300 AU along the semiminor axis. The radial surface brightness profile and the presence of both reflection nebulosity and molecular gas suggest that we have detected the flared surface of the disk predicted from analysis of the IR spectral energy distribution. When corrected for the r-2 falloff in illumination from the Herbig Be star, the reflection nebulosity, neutral atomic gas, and H2 emission all reveal the presence of a central cavity extending 0. ″13 ± 0. ″025 (13 AU) from the star, more than 20 times larger in radius than would be expected from dust sublimation alone. The reflection nebulosity within the cavity is centered on a location 0. ″05 (5 AU) to the southeast of the star along the system semimajor axis. The pericenter asymmetry in the cavity is inconsistent with cavity formation by the combined effects of ice sublimation, radiation pressure blowout on small grains, or other disk chemistry that should produce azimuthally symmetric features. The STIS data are also consistent with a current accretion rate onto the Herbig Be star no higher than a few times 10-9 M☉ yr-1, an order of magnitude lower than seen in 5-8 Myr old Herbig Ae stars. The low accretion rate, large cavity, pericenter asymmetry, and deficit of warm dust grain emission observed over 2-8 μm are all consistent with dynamical sculpting of the disk by one or more bodies within the disk. An upper limit to the flux from any chromospherically active, low-mass companion is a factor of 5-10 fainter than AU Mic (M1 Ve; t = 12 Myr) at the distance of HD 100546. This upper limit firmly excludes a low-mass stellar companion within the cavity but does not exclude a less active and/or luminous brown dwarf. The absence of similar central clearing in younger Herbig Ae stars suggests that any companion must become externally detectable late in the evolution of the disk, favoring a giant planet as the source of the structure in the HD 100546 disk.
Polyphenols as Drivers of a Homeostatic Gut Microecology and Immuno-Metabolic Traits of Akkermansia muciniphila: From Mouse to Man

Akkermansia muciniphila is a mucosal symbiont considered a gut microbial marker in healthy individuals, as its relative abundance is significantly reduced in subjects with gut inflammation and metabolic disturbances. Dietary polyphenols can distinctly stimulate the relative abundance of A. muciniphila, contributing to the attenuation of several diseases, including obesity, type 2 diabetes, inflammatory bowel diseases, and liver damage. However, mechanistic insight into how polyphenols stimulate A. muciniphila or its activity is limited. This review focuses on dietary interventions in rodents and humans and in vitro studies using different phenolic classes. We provide critical insights with respect to potential mechanisms explaining the effects of polyphenols affecting A. muciniphila. Anthocyanins, flavan-3-ols, flavonols, flavanones, stilbenes, and phenolic acids are shown to increase relative A. muciniphila levels in vivo, whereas lignans exert the opposite effect. Clinical trials show consistent findings, and high intervariability relying on the gut microbiota composition at the baseline and the presence of multiple polyphenol degraders appear to be cardinal determinants in inducing A. muciniphila and associated benefits by polyphenol intake. Polyphenols signal to the AhR receptor and impact the relative abundance of A. muciniphila in a direct and indirect fashion, resulting in the restoration of intestinal epithelial integrity and homeostatic crosstalk with the gut microbiota by affecting IL-22 production. Moreover, recent evidence suggests that A. muciniphila participates in the initial hydrolysis of some polyphenols but does not participate in their complete metabolism. In conclusion, the consumption of polyphenol-rich foods targeting A. muciniphila as a pivotal intermediary represents a promising precision nutritional therapy to prevent and attenuate metabolic and inflammatory diseases.
EFFECT OF COPING STRATEGIES PROGRAM ON QUALITY OF LIFE AND BURDEN OF CARE AMONG FAMILY CAREGIVERS OF ALZHEIMER PATIENTS

Background : Improving the effective coping strategies of caregivers of Alzheimer's patients lead to a decrease in care pressure and ultimately, promotion of their health. Aim: To evaluate the effect of coping strategies program on quality of life and burden of care among caregivers of Alzheimer patients at Port Said City. Design : A quasi-experimental design was applied. Setting : This study was carried out at neurologic outpatient clinics of the psychiatric hospital in Port Said city. Subjects : Purposive sample (110) of all family caregivers of the Alzheimer's patients were included in this study. Tools of data collection : The Family Caregivers' Socio-Demographic Information Questionnaire; Caregivers' Burden Scale; and Short Form Health-Related Quality of Life translated Scale were used. Results: Mean age of the caregivers was 41.36 ± 12.74 years and 70.9% of them were females. There was a reduction in total caregivers’ burden in post-test phase of the program compared to the pre and follow-up stages. In addition, there were highly statistically significant differences between total items of the caregiver burden assessment through all phases of the program. Also, there was an obvious improvement in the caregivers’ quality of life levels during the program. Conclusion: After implementation of the program, those Caregivers who received the designed program reduced their care burden experienced and affected their quality of life positively. Recommendations : Continuous health educations programs for caregivers of Alzheimer's patients are necessary needed and further studies using a large study sample size in different settings are highly recommended.
Organoid Technology and Its Role for Theratyping Applications in Cystic Fibrosis

Cystic fibrosis (CF) is a autosomal recessive, multisystemic disease caused by different mutations in the CFTR gene encoding CF transmembrane conductance regulator. Although symptom management is important to avoid complications, the approval of CFTR modulator drugs in the clinic has demonstrated significant improvements by targeting the primary molecular defect of CF and thereby preventing problems related to CFTR deficiency or dysfunction. CFTR modulator therapies have positively changed the patients’ quality of life, especially for those who start their use at the onset of the disease. Due to early diagnosis with the implementation of newborn screening programs and considerable progress in the treatment options, nowadays pediatric mortality was dramatically reduced. In any case, the main obstacle to treat CF is to predict the drug response of patients due to genetic complexity and heterogeneity. Advances in 3D culture systems have led to the extrapolation of disease modeling and individual drug response in vitro by producing mini organs called “organoids” easily obtained from nasal and rectal mucosa biopsies. In this review, we focus primarily on patient-derived intestinal organoids used as in vitro model for CF disease. Organoids combine high-validity of outcomes with a high throughput, thus enabling CF disease classification, drug development and treatment optimization in a personalized manner.
Alpha-Lipoic Acid and Its Enantiomers Prevent Methemoglobin Formation and DNA Damage Induced by Dapsone Hydroxylamine: Molecular Mechanism and Antioxidant Action

Dapsone (DDS) therapy can frequently lead to hematological side effects, such as methemoglobinemia and DNA damage. In this study, we aim to evaluate the protective effect of racemic alpha lipoic acid (ALA) and its enantiomers on methemoglobin induction. The pre- and post-treatment of erythrocytes with ALA, ALA isomers, or MB (methylene blue), and treatment with DDS-NOH (apsone hydroxylamine) was performed to assess the protective and inhibiting effect on methemoglobin (MetHb) formation. Methemoglobin percentage and DNA damage caused by dapsone and its metabolites were also determined by the comet assay. We also evaluated oxidative parameters such as SOD, GSH, TEAC (Trolox equivalent antioxidant capacity) and MDA (malondialdehyde). In pretreatment, ALA showed the best protector effect in 2.5 µg/mL of DDS-NOH. ALA (1000 µM) was able to inhibit the induced MetHb formation even at the highest concentrations of DDS-NOH. All ALA tested concentrations (100 and 1000 µM) were able to inhibit ROS and CAT activity, and induced increases in GSH production. ALA also showed an effect on DNA damage induced by DDS-NOH (2.5 µg/mL). Both isomers were able to inhibit MetHb formation and the S-ALA was able to elevate GSH levels by stimulating the production of this antioxidant. In post-treatment with the R-ALA, this enantiomer inhibited MetHb formation and increased GSH levels. The pretreatment with R-ALA or S-ALA prevented the increase in SOD and decrease in TEAC, while R-ALA decreased the levels of MDA; and this pretreatment with R-ALA or S-ALA showed the effect of ALA enantiomers on DNA damage. These data show that ALA can be used in future therapies in patients who use dapsone chronically, including leprosy patients.
Stress-associated metabolites vary with both season and habitat across populations of a climate sentinel species

ABSTRACT Relating physiological stress to habitat quality could refine conservation efforts. Habitat quality, which is often inferred from patch occupancy or demographic rates, might be measured in a more timely and nuanced way using metrics of physiological stress. To understand whether stress-associated hormones vary with metrics of habitat quality, we measured fecal glucocorticoid metabolite (FGM) levels in the American pika (Ochotona princeps), a small mammal with well-defined habitat (talus), which can vary in quality depending on the presence of subsurface ice features. In spring and fall 2018, we collected feces noninvasively from pika territories in taluses “with” or “without” subsurface ice to capture seasonal variation in FGM between habitat types. We used linear mixed effects models to explore the interactions among season, habitat metrics (including subsurface ice status), and subsurface temperature as predictors of FGM. We found support for interacting effects on FGM levels, which covaried with season, elevation, putative ice presence, graminoid to forb ratio, graminoid cover, and measures of acute subsurface heat exposure. However, only one subsurface temperature metric differed according to putative presence of subsurface ice. Our results contribute to the growing evidence that FGMs might be developed as a tool to assess habitat quality.
Polymorphism of prolactin (PRL) gene exon 5 and its association with egg production in IPB-D1 chickens.

The prolactin (PRL) gene regulates the egg production and incubation in laying chickens. Local chickens' reproductive systems will disrupt as a result of the incubation period activity, and they will lay fewer eggs. This study aimed to determine the prolactin gene polymorphism in IPB-D1 hens and its relationship to egg production. The polymorphism of the exon 5 prolactin gene was examined on 112 samples of the IPB-D1 chicken DNA collection from the Division of Animal Genetics and Breeding, Faculty of Animal Sciences, IPB University. By performing the phenol-chloroform method, the genomic DNA was obtained. A polymerase chain reaction (PCR) product with a size of 557 bp was produced as a result of the DNA amplification. Three single-nucleotide sequences were discovered. Three single-nucleotide polymorphisms (SNPs), g.7835A > G, g.7886A > T, and g.8052T > C, were found in exon 5 of the PRL gene. Each mutation was polymorphic and in Hardy-Weinberg equilibrium. The point mutation g.8052T > C significantly impacted the egg production of IPB-D1 chickens, according to the SNP association analysis on egg production, and may serve as a marker to enhance the selection for the features of egg production in IPB-D1 chickens.
Information Technology in Health-Care Systems and Primary Health Care

BACKGROUND: Health information technology (HIT) is being increasingly necessary to manage the ever-increasing amount of data generate by the health system in general, including primary health care (PHC). AIM: This study aimed to provide an overview of HIT being currently use in the health systems and PHC as well as to highlight the advantages and disadvantages of HIT options. METHODS: This is a narrative literature review of papers, documents, and websites that address and discuss HIT for the health systems. The analysis of the retrieved materials provided an overview of the importance of HIT for the health system, the various options of health technology currently available, as well as the future trends. Strengths and weaknesses have been highlighted as well. RESULTS: HIT is being increasingly used in the health sector, as an indispensable tool to handle the extraordinary amount of data being generated by the health system but also as an instrument to improve the quality of health care through the reduction of medical errors and health care-associated costs, improvement of patient follow-up and monitoring, and also as a tool that informs and guides clinical decision-making. A large variety of HIT options is available, including telehealth, telemedicine, mobile health, electronic medical records, electronic health records, personal health records, electronic prescriptions (e-prescriptions), wearables, metadata, and even artificial intelligence. Each HIT option has its own advantages and disadvantages. PHC could benefit from the implementation of various HIT options. CONCLUSIONS: The decision which HIT option(s) to employ will depend on many factors, but the process needs to employ small steps, strong political will, cooperation, and coordination between all stakeholders.
Estimation and testing for the parameters of ARCH(q) under ordered restriction

Abstract. In this paper, we study a stationary ARCH(q) model with parameters α0,α1,α2,…,αq. It is known that the model requires all parameters αi to be non‐negative, but sometimes the usual algorithm based on Newton–Raphson's method leads us to obtain some negative solutions. So this study proposes a method of computing the maximum likelihood estimator (MLE) of parameters under the non‐negative restriction. A similar method is also proposed for the case where the parameters are restricted by a simple order: α1≥α2≥⋯≥αp. The strong consistency of the above two estimators is discussed. Furthermore, we consider the problem of testing homogeneity of parameters against the simple order restriction. We give the likelihood ratio (LR) test statistic for the testing problem and derive its asymptotic null distribution.