Miracle-dz/UniFAR-FTUs huggingface dataset:
Broadband external cavity tuning in the 3-4 μm window

In this work, a continuous external cavity spectral tuning of 556 cm−1 in the 3–4 μm region is shown for a heterogeneous bound-to-continuum active region design based on the strain-compensated Sb-free material system. The two active regions have center wavelengths at 3.3 μm and 3.7 μm with a total modal overlap factor of 86%. We also show an effective multilayer broadband anti-reflectivity coating in the 3–4 μm region reducing the overall reflectivity over the whole tuning range below 1.4%.
Two mutations in the SBDS gene reveal a diagnosis of Shwachman–Diamond syndrome in a patient with atypical symptoms

We present the case of a 53-yr-old woman with an inherited bone marrow failure coexisting with uncommon extrahematological symptoms, such as cirrhosis and skin abnormalities. Whole-exome sequencing revealed a diagnosis of Shwachman–Diamond syndrome (SDS) with an atypical presentation. Unexpected was the age of disease expression, normally around the pediatric age, with a predominantly median survival age of 36 yr. To our knowledge, she was the first adult patient with a molecular diagnosis of Shwachman–Diamond in Uruguay. The patient was referred to our service when she was 43-yr-old with a history of bone marrow failure with anemia and thrombocytopenia. All secondary causes of pancytopenia were excluded. Bone marrow aspirate and biopsy specimens were hypocellular for the patient's age. Numerous dysplastic features were observed in the three lineages. She had a normal karyotype and normal chromosomal fragility. A diagnosis of low-risk hypoplastic MDS was made. Dermatological examination revealed reticulate skin pigmentation with hypopigmented macules involving the face, neck, and extremities; nail dystrophy; premature graying; and thin hair. Extrahematological manifestations were present (e.g., learning difficulties, short stature). Last, she was diagnosed with cryptogenic liver cirrhosis CHILD C. This rules out all other possible causes of chronic liver disease. This clinical presentation initially oriented the diagnosis toward telomeropathy, so we did a telomeropathy NGS panel that came up negative. Finally, we did an exome sequencing that confirmed the diagnosis of SDS. Using whole-exome sequencing, we were able to find two compound heterozygous mutations in the SBDS gene that were responsible for the phenotype of a patient that was undiagnosed for 10 years. An earlier genetic diagnosis could have influenced our patient's outcome.
Response comments on: A deep dive into the latest European Glaucoma Society and Asia-Pacific Glaucoma Society guidelines and their relevance to India

We agree that Fig. 1 is incompletely labeled and should mention the scleral spur as a structure visible. Inadvertently, the text boxes in Fig. 1 for PACS say “yes” instead of “no.” With that correction, the definitions of PAC are in line with the APGS guidelines. The addition of acetazolamide/mannitol would depend on the level of intraocular pressure (IOP) and whether it can be safely administered. Anti‐glaucoma drugs work even with elevated IOP because they act at the receptor level. In the case of pilocarpine where the desired effect is on the sphincter pupillae, the lack of an effect is because the elevated IOP because of the pupillary block results in sphincter ischemia. We have referenced the European Glaucoma Society (EGS) for the statement. “However, it is also recommended in those whose glaucoma is relatively nonprogressive. ” Because we did not reproduce each statement of the guideline, this was omitted. We agree that “reviewed” may be semantically more accurate that “revised. ” However, the paragraph just before this clearly states “Both the EGS and APGS guidelines discuss setting an IOP target. The panel list agreed that a target IOP should be personalized and constantly re‐evaluated in the milieu of the stage of the disease.
Effects of Sexual Rehabilitation on Sexual Dysfunction in Patients with Cardiovascular Disease: A Systematic Review and Meta-Analysis

Purpose Cardiovascular disease (CVD) is one of the leading causes of death, accounting for one-third of all deaths worldwide. Patients with CVD are three times more likely to complain of sexual dysfunction than healthy people. Causes of sexual dysfunction in patients with CVD include physical/mental changes and drug side effects. The prevalence of sexual dysfunction in patients with CVD has been estimated to be up to 89%. Ordinary treatments such as pharmacotherapy cannot effectively reduce sexual problems. Therefore, sexual rehabilitation has a broad spectrum, including exercise therapy such as pelvic floor muscle treatment, appropriate counseling, a multidisciplinary approach, and partner rehabilitation. In this study, systematic review and meta-analysis was performed to investigate the effect of sexual rehabilitation on sexual problems in patients with CVD. Materials and Methods Comprehensive literature searches were conducted using MEDLINE, Cochrane Library electronic database, and EMBASE through June 2022. Questionnaire scores at the end point as outcomes of the study were recorded as were standardized mean difference (SMD) with their 95% confidence intervals (CIs). Meta-regression analysis was conducted for each moderator. We performed a risk of bias evaluation for included studies using the RoB 2 tool. Results The overall SMD in the meta-analysis for sexual rehabilitation versus no-sexual rehabilitation was 0.430 (95% CI, 0.226–0.633). There was a statistical difference between groups. SMD changes were 0.674 (95% CI, 0.308–1.039) at one month and 0.320 (95% CI, 0.074–0.565) at six months. The regression analysis with all variables (number of patients, study duration, and questionnaire types) revealed no significance. Conclusions This study indicates that sexual rehabilitation is an effective method with high therapeutic potential for sexual dysfunction of patients with CVD. However, for clinical application, well-designed studies with many patients should be conducted in the future and the standardization of rehabilitation protocols is required.
Thermodynamic Model of Ideal Magnetostriction

A self-consistent model of ideal magnetostriction is presented on a thermodynamic basis for the coupling between magnetostriction of ferromagnets and the behaviour of magnetization or induction curves (an anhysteretic approach is developed). The model is based on a rigorous adherence to the energy conservation law which is written in a characteristic differential form. The author employed an additional assumption concerning the presence of saturation effects to obtain a magnetic equation of state for some ferromagnetic materials. The coefficient κ is introduced for the coupling between magnetic and mechanical processes. A mechanical equation of state (the expression for magnetostriction) is derived using the thermodynamic Maxwell reciprocity relations. The separation of strains into magnetic and purely mechanical parts comes about as a logical consequence of the self-consistent approach. The conclusion is made that the well-known Villari and Joule effects can be treated as a coupling between magnetic and mechanical processes within the framework of an invariant coupling coefficient. The behaviour of the magnetostrictional modulus of elasticity for ferromagnetic materials is discussed and, as is shown, it takes on negative values within a certain range of the magnetic field and mechanical stress. The last Section of the paper concentrates briefly on the strength problems. Modeling results are in a good agreement with experiments.
Determining the relative permittivity and thickness of a lossless dielectric overlayer on a metal film using optically excited surface plasmon polaritons

Numerical simulations based on the exact Fresnel equations are used to show that it is possible to determine uniquely the relative permittivity and thickness of a thin lossless dielectric film adsorbed on a gold or silver layer. The calculations, which include the effects of up to 1% random noise on the experimental data, show clearly that there is no degeneracy in the solutions of the Fresnel equations even for films as thin as 2 nm. It is shown that gold is preferable to silver as a substrate when the overlayer properties need to be determined accurately. It is further shown that, if the overlayer is bounded by water rather than air, then the experimental constraints would preclude the use of silver as a substrate but measurements would still be possible with gold.
First clinical experience using the DiamondTemp catheter and a novel omnipolar high-resolution mapping system for atrial fibrillation ablation

Background The DiamondTemp (DT) radiofrequency ablation (RFA) catheter has been introduced as a new tool for atrial fibrillation (AF) ablation. The new technology allows for temperature-controlled irrigated ablation and real-time lesion assessment. Recently, the EnSite X mapping system became commercially available allowing for omnipolar and ultra-high-resolution mapping. We aimed to assess the feasibility of the new DT RFA catheter in performing AF ablation procedures in conjunction with the novel EnSite X system under routine clinical conditions. Methods We analyzed data from 10 consecutive patients who underwent AF ablation using the DT RFA catheter guided by EnSite X. Procedural data and short-term follow-up were assessed as well as potential technical issues. Results Nine out of 10 patients underwent de-novo pulmonary vein isolation (PVI), and 1 patient underwent repeat ablation. First-pass isolation was observed in 7/10 patients. Total procedure duration (skin-to-skin) was 88.9 ± 30.1 min, and left atrium dwell time was 70 ± 22.3 min. The mean number of RF applications needed for PVI and additional ablation was 70.52 ± 26.70. The HD Grid SE mapping catheter was utilized in 8 patients and the Advisor SE in 2 patients. Bidirectional block of the applied lines was achieved in all patients. No steam pops were observed, and no intraprocedural complications occurred. Conclusions This first clinical series demonstrated that temperature-controlled irrigated ablation in combination with the novel omnipolar and high-resolution mapping system resulted in rapid, efficient, and durable lesion formation under routine clinical conditions. Randomized controlled trials are needed to elucidate the impact on lesion formation, long-term outcomes, and reproducibility of our initial findings.
Watermarking of vector map based on wavelet transform

An algorithm for watermarking of vector map based on discrete wavelet transform is presented in this paper. The watermarking information is represented by a bi-valued sequence. We embed the watermark repeatedly in the magnitude of the DWT coefficients vertices, which are extracted from the map. Considering the precision of the watermarked map might be violated and the map's usability might be damaged, the intensity of the watermark should be adjusted in the spatial domain until it meets the precision standard. Experiment results show that the watermark is significant but not violate the map's precision. The proposed algorithm is robust against some attacks.
DEVELOPMENT OF A MACHINE LEARNING MODEL FOR PREDICTING 28-DAY MORTALITY OF SEPTIC PATIENTS WITH ATRIAL FIBRILLATION

ABSTRACT ABSTRACT Introduction: Septic patients with atrial fibrillation (AF) are common in the intensive care unit accompanied by high mortality. The early prediction of prognosis of these patients is critical for clinical intervention. This study aimed to develop a model by using machine learning (ML) algorithms to predict the risk of 28-day mortality in septic patients with AF. Methods: In this retrospective cohort study, we extracted septic patients with AF from the Medical Information Mart for Intensive Care III (MIMIC-III) and IV database. Afterward, only MIMIC-IV cohort was randomly divided into training or internal validation set. External validation set was mainly extracted from MIMIC-III database. Propensity score matching was used to reduce the imbalance between the external validation and internal validation data sets. The predictive factors for 28-day mortality were determined by using multivariate logistic regression. Then, we constructed models by using ML algorithms. Multiple metrics were used for evaluation of performance of the models, including the area under the receiver operating characteristic curve, sensitivity, specificity, recall, and accuracy. Results: A total of 5,317 septic patients with AF were enrolled, with 3,845 in the training set, 960 in the internal testing set, and 512 in the external testing set, respectively. Then, we established four prediction models by using ML algorithms. AdaBoost showed moderate performance and had a higher accuracy than the other three models. Compared with other severity scores, the AdaBoost obtained more net benefit. Conclusion: We established the first ML model for predicting the 28-day mortality of septic patients with AF. Compared with conventional scoring systems, the AdaBoost model performed moderately. The model established will have the potential to improve the level of clinical practice.
Cytotoxic Activity of Herbal Medicines as Assessed in Vitro: A Review

Since time immemorial, human beings have sought natural medications for treatment of various diseases. Weighty evidence demonstrates the use of chemical methodologies for sensitive evaluation of cytotoxic potentials of herbal agents. However, due to the ubiquitous use of cytotoxicity methods, there is a need for providing updated guidance for the design and development of in vitro assessment. The aim of this review is to provide practical guidance on common cell‐based assays for suitable assessment of cytotoxicity potential of herbal medicines and discussing their advantages and disadvantages Relevant articles in authentic databases, including PubMed, Web of Science, Science Direct, Scopus, Google Scholar and SID, from 1950 to 2022 were collected according to selection criteria of in vitro cytotoxicity assays and protocols. In addition, the link between cytotoxicity assay selection and different factors such as the drug solvent, concentration and exposure duration were discussed.
Hochschild homology with coefficients in an $H$-unital ideal

Let k be a field and I an H-unital two-sided ideal of an associative unital k-algebra A. Then, based on Wodzicki’s work, we show that the Hochschild homology groups of A with coecients in I are isomorphic to the Hochschild homology groups of I.
Nerve growth factor causes epinephrine release dysfunction by regulating phenotype alterations and the function of adrenal medullary chromaffin cells in mice with allergic rhinitis

The presence of allergic rhinitis (AR) is an increased risk factor for the occurrence of bronchial asthma (BA). Nerve growth factor (NGF), in addition to its key role in the development and differentiation of neurons, may also be an important inflammatory factor in AR and BA. However, the pathogenesis of the progression of AR to BA remains to be elucidated. The present study aimed to investigate the ability of NGF to mediate nasobronchial interactions and explore possible underlying molecular mechanisms. In the present study, an AR mouse model was established and histology of nasal mucosa tissue injury was determined. The level of phenylethanolamine N-methyl transferase in adrenal medulla was determined by immunofluorescence. Primary adrenal medullary chromaffin cells (AMCCs) were isolated and cultured from the adrenal medulla of mice. The expression levels of synaptophysin (SYP), STAT1, JAK1, p38 and ERK in NGF-treated and untreated AMCCs were detected by reverse-transcription-quantitative PCR and western blotting. The epinephrine (EPI) and norepinephrine (NE) concentrations were measured by ELISA. It was found that the expression of SYP in AMCCs was enhanced in the presence of NGF, whereas, the concentration of EPI decreased significantly under the same conditions. Furthermore, NGF mediated the phenotypic and functional changes of AMCCs, resulting in decreased EPI secretion via JAK1/STAT1, p38 and ERK signaling. In conclusion, these findings could provide novel evidence for the role of NGF in regulating neuroendocrine mechanisms.
Low Bone Mineral Density and Associated Risk Factors in Elite Cyclists at Different Stages of a Professional Cycling Career

ABSTRACT Purpose This study aimed to assess the prevalence of low bone mineral density (BMD) in male and female elite cyclists at different stages of a professional cycling career and to identify potential risk factors of low BMD. Methods In this cross-sectional study, 93 male and female early career, advanced career, and postcareer elite cyclists completed dual-energy x-ray absorptiometry at the hip, femoral neck, lumbar spine, and total body; blood sampling; assessment of training history and injuries; and the bone-specific physical activity questionnaire. Backward stepwise multiple regression analyses were conducted to explore associations between BMD and its potential predictors in early and advanced career (i.e., active career) cyclists. Results With a mean Z-score of −0.3 ± 0.8, −1.5 ± 1.0, and −1.0 ± 0.9, low BMD (Z-score < −1) at the lumbar spine was present in 27%, 64%, and 50% of the early, advanced, and postcareer elite male cyclists, respectively. Lumbar spine Z-scores of −0.9 ± 1.0, −1.0 ± 1.0, and 0.2 ± 1.4 in early, advanced, and postcareer elite female cyclists, respectively, indicated low BMD in 45%, 45%, and 20% of these female subpopulations. Regression analyses identified body mass index, fracture incidence, bone-specific physical activity, and triiodothyronine as the main factors associated with BMD. Conclusions Low BMD is highly prevalent in elite cyclists, especially in early career females and advanced career males and females. These low BMD values may not fully recover after the professional cycling career, given the substantial prevalence of low BMD in retired elite cyclists. Exploratory analyses indicated that low BMD is associated with low body mass index, fracture incidence, lack of bone-specific physical activity, and low energy availability in active career elite cyclists.
SU‐FF‐I‐30: Generating Attenuation‐Based Tube Current Modulation (TCM) Schema Based On Voxelized Patient Models to Be Used in Simulations Estimating Organ Dose From CT

Purpose: There are several TCM algorithms in CT acquisition currently used including x‐y plane modulation, z‐axis only modulation and combined (x,y,z) modulation techniques. While these have been used to reduce radiation dose in general, methods do not yet exist to assess their impact on reducing organ dose. This study establishes a generalizable process to generate TCM schema from various attenuation‐based algorithms for use in Monte Carlo simulation methods to assess organ dose from voxelized patient models. Methods and Materials: A previously validated scanner‐specific Monte Carlo‐based CT scanner model was altered to allow simulation of a topogram with the x‐ray tube held at an assigned gantry angle. An Anterior‐Posterior (AP) and a Lateral topogram were simulated on a voxelized patient model. A cylindrical mesh tally was used to calculate attenuation for every slice location along the cranial‐caudal direction of the patient and for angular increments around the gantry of the patient. A plot of patient attenuation versus table position was obtained for both topograms. The ideal TCM was calculated for each table position and the entire three‐dimensional TCM schema was generated by interpolating between the ideal TCM plots to maintain smooth tube current transitions for the remainder of the gantry rotation. Results: Using this generalizable model, we were able to generate the attenuation‐based TCM schema for a voxelized patient model. Conclusion: The results of this study demonstrate the ideal TCM schema for a specific TCM algorithm, but this generalizable model can be used to generate the ideal TCM schema for any combination of gantry angle, table location, and width of detector data. Therefore, this generalizable model can be used to generate TCM schema based on all types of attenuation‐based TCM algorithms and for any voxelized patient model.
Resonant inelastic x-ray scattering ofMnO:L2,3edge measurements and assessment of their interpretation

The resonant inelastic x-ray scattering (RIXS) of $\mathrm{MnO}$ measured with high energy resolution across the ${\mathrm{L}}_{2,3}$ absorption edges of Mn is characterized by a very rich spectral structure due to the local electronic excitations. The spectra are dominated by dd and charge transfer excitations, both dipole allowed in the RIXS process. The spectra strongly depend on the energy and polarization of the incident photons. This vast experimental basis allows an accurate determination of the main parameters of theoretical models used to describe highly correlated electron systems like $\mathrm{MnO}$. We show the results for the single impurity Anderson model and the single ion crystal field model and we compare them. Both models reproduce well the dd excitation spectrum, but the former can also predict satisfactorily the charge transfer excitations.
Disrupted redox balance in utero-placenteal junction may be the main culprit in the occurrence of abruptio placenta.

OBJECTIVE To determine the oxidant/antioxidant balance and proinflammatory status in amniotic fluids collected during cesarean section of patients diagnosed with abruptio placenta. PATIENTS AND METHODS Twenty-five patients diagnosed with ablatio placenta with intact membranes who went to emergency cesarean section were included in the study. A diagnosis of AP was made in those who had at least one of the following criteria or, in suspicious cases, two findings. (i) Antepartum hemorrhage starting after 20 weeks of gestation, (ii) presence of retroplacental hematoma on ultrasonography, (iii) severe fetal distress or death, (iv) localized or diffuse uterine tenderness or pain. The control group consisted of 25 patients who presented for delivery, who were not diagnosed with AP, and whose membranes were intact. NF-κB, total oxidant capacity (TOC), total antioxidant capacity (TAC), and oxidative stress index (TOC/TAC=OSI) levels were measured in amniotic fluids collected during cesarean section from both groups. RESULTS Amniotic fluid TAS values of the AP group were significantly lower than the healthy controls (1.14±0.33 vs. 9.05.±3.40, p<0.01). Amniotic fluid TOS values were significantly increased in the AP group (36.1±8.10 vs. 11.4±2.77, p<0.02). OSI values were significantly higher in the AP group (31.6±9.03 vs. 1.26±0.02, p<0.01). Amniotic fluid NF-κB expression of the AP group was approximately 5 times higher than the control group (10.4±2.56 ng/mL vs. 1.86±0.30 ng/mL, p<0.01). High blood pressure and smoking history were significantly higher in the AP group. Gestational age and fetal birth weight of the AP group were lower than the control group. CONCLUSIONS Since the increase in amniotic fluid oxidant capacity and proinflammatory cytokine synthesis cannot be neutralized by the antioxidant system, hypoxic cell damage may lead to premature separation of the placenta.
Quantum entanglement criteria

Abstract We review the main criteria used to detect entanglement in quantum systems. The main properties of each criteria are summarized depending on whether the criteria provides a sufficient or necessary condition, whether it involves density matrix or operators, or if the criteria is phase sensitive. We show that several criteria have much in common and they could be related mathematically. We also discuss the features of entanglement which are useful in quantum information technology.