Miracle-dz/UniFAR-FTUs huggingface dataset:
STATIONARY SOLUTIONS AND TRANSITION CONDITIONS FOR THE NON-SMOOTH MOTION OF ROTOR SYSTEMS WITH UNILATERAL CONSTRAINTS

, ABSTRACT This paper presents a method for providing stationary solutions for rotor systems with a considerable number of unilateral constraints, such as normal contact due to cracks or delaminations in rotating shafts. In more general manner, systems with moving continua or internal ﬂow, for example a pipe resting on unilateral supports, rank among the same class of problems. It is shown that, by virtue of centrifugal effects, the existence of stationary solutions is not guaranteed without restrictions. Sufﬁcient existence conditions are given for an important class of rotor systems and are based on ﬁndings from the theory of Complementarity Problems. Furthermore, the presented method comprises an approach to assess the stability of the solution and a modiﬁcation is given to determine the velocity jumps when a contact conﬁguration change occurs during the system’s non-smooth evolution.
Detection and Host Defense Pattern Recognition Molecules for Pathogen Domain-Like Receptors: Intracellular Nucleotide-Binding Oligomerization

The nucleotide binding oligomerization domain-like receptor (NLR) family of pattern recognition molecules is involved in a diverse array of processes required for host immune responses against invading pathogens. Unlike TLRs that mediate extracellular recognition of microbes, several NLRs sense pathogens in the cytosol and upon activation induce host defense signaling pathways. Although TLRs and NLRs differ in their mode of pathogen recognition and function, they share similar domains for microbial sensing and cooperate to elicit immune responses against the pathogen. Genetic variation in several NLR genes is associated with the development of inflammatory disorders or increased susceptibility to microbial infection. Further understanding of NLRs should provide critical insight into the mechanisms of host defense and the pathogenesis of inflammatory diseases. The Journal of Immunology, 2006, 177: 3507–3513. n well as ability to the recognizes presence (i.e., (i.e., Three recognition molecules cooperate in host defense include TLRs, nucleotide-binding oligomerization domain (Nod)-like receptors (NLRs), and retinoid barriers and macrophages. A , Secretion of human (cid:4) -defensin-2 by gastric epithelial cells in response to H. pylori is dependent on the type IV secretion system of the bacterium that injects iE-DAP-containing molecules into the host cytosol. Nod1 is then activated, leading to induction of the human (cid:4) -defensin-2 gene via the induction of NF- (cid:2) B. B , The presence of bacterial infection is sensed by epithelial cells from tis-sues, such as the intestine and lung, through the recognition of iE-DAP molecules in the host cytosol. Recognition leads to the induction of che- mokine genes and recruitment of neutrophils to the infection site. C, Elim-ination of commensal and pathogenic bacteria through the secretion of an- timicrobial peptides by Paneth cells. Nod2 is thought to contribute to this process through the regulation of (cid:3) -defensin expression and secretion. D, Stimulation of TLRs induces the production of pro-IL-1 (cid:4) , whereas the activation of Ipaf by flagellin induces the activation of caspase-1 in response to Salmonella . Tolerization of TLR pathways does not affect Ipaf-induced caspase-1 activation because macrophages tolerant to TLR stimulation re-tain their ability to produce high levels of IL-1 (cid:4)
Impaired activation of platelets lacking protein kinase C- (cid:1) isoform

Protein kinase C (PKC) isoforms have been implicated in several platelet functional responses, but the contribution of individual isoforms has not been thoroughly evaluated. Novel PKC isoform PKC- (cid:1) is activated by glycoprotein VI (GPVI) and protease-activated receptor (PAR) agonists, but not by adenosine diphosphate. In human platelets, PKC- (cid:1) –selective antagonistic (RACK; receptor for activated C kinase) peptide signiﬁcantly inhibited GPVI and PAR-induced aggregation, dense and (cid:2) granule secretion at low agonist concentrations. Consistently, in murine platelets lacking PKC- (cid:1) , platelet aggregation and secretion were also impaired. PKC-mediated phosphorylation of tSNARE protein syntaxin-4 was strongly reduced in human platelets pretreated with PKC- (cid:1) RACK peptide, which may contribute to the lower levels of granule secretion when PKC- (cid:1) function is lost. Furthermore, the level of JON/A binding to activated (cid:2) IIb (cid:3) 3 receptor was also signiﬁcantly decreased in PKC- (cid:1) (cid:4) / (cid:4) mice compared with wild-type littermates. PKC- murine platelets showed signiﬁcantly lower agonist-induced thromboxane (TXA 2 ) release through reduced extracel-lular signal–regulated kinase phosphorylation. Finally, PKC- (cid:1) (cid:4) / (cid:4) mice displayed unstable thrombus formation and prolonged arterial occlusion in the FeCl 3 in vivo thrombosis model compared with wild-type mice. Inconclusion,PKC- (cid:1) isoformplaysasigniﬁ-cant role in platelet functional responses downstream of PAR and GPVI receptors. (Blood.2009;113:2557-2567) a regulator in agonist-induced inside-out signaling and ﬁbrinogen In the study, we show for the ﬁrst time that GPVI and PAR activation, but not P2Y receptor activation, causes Thr538 phosphorylation on PKC- (cid:1) , and this isoform has a signiﬁcant role in platelet aggregation and activation of (cid:2) IIb (cid:4) 3 receptors. Further-more, this PKC isoform also mediates the agonist-induced ATP release, P-selectin expression, and TXA 2 generation downstream of GPVI and PAR signaling. More signiﬁcantly, we also demonstrated unstable thrombus formation and prolonged arterial occlusion in PKC- (cid:1) / mice compared with WT littermates in the FeCl 3 in vivo thrombosis model. From these results, we conclude that PKC- (cid:1) plays an important role in GPVI- and PAR-mediated platelet activation. between WT and PKC- (cid:1) (cid:9) / (cid:9) murine platelets, or in the presence of the RACK or control peptide in human platelets (data not shown). These results demonstrate that PKC- (cid:1) positively regulates aggregation and dense granule secretion on GPVI- and PAR-mediated platelet activation in platelets. direct functional role in TXA 2 generation through regulating ERK phosphorylation on GPVI and PAR platelet activation.
rpoD Operon Promoter Used by cH-RNA Polymerase in Bacillus subtilis

Three promoters direct transcription of the sigA (rpoD) operon in Bacillus subtilis. Promoters P1 and P2 are used during the exponential growth phase, whereas P3 is used only during the stationary phase. We examined the use of these promoters in promoter-probe plasmids and found that expression from P3 was prevented by a mutation in spoOH, which encodes the secondary RNA polymerase sigma factor (7H. Moreover, we found that r H-containing RNA polymerase efficiently and accurately used the P3 promoter in vitro. Evidently, this operon, which is essential for exponential growth, is transcribed during the early phase of sporulation by this secondary form of RNA polymerase. Comparison of the nucleotide sequences of the P3 promoter and the spoVG promoter, which also is used by CH -RNA polymerase, revealed sequences at the -10 and -35 regions of these promoters that may signal recognition of promoters by gH-RNA polymerase. The operons that include the structural genes for the primary RNA polymerase sigma factors in Escherichia coli and Bacillus subtilis are similar. In E. coli the promoter- proximal gene of the operon, rpsU, encodes the ribosomal protein S21, the second gene, dnaG, encodes the DNA primase, and, finally, rpoD encodes the primary RNA polymerase sigma factor C70 (2, 12). In the B. subtilis operon, the second and third genes, dnaE and rpoD, which encode DNA primase and the primary sigma factor, a4 ((rA), respectively, are homologous to dnaG (18) and rpoD (6), respectively, of E. coli. However, the first gene, P23 in the B. subtilis
Intend And Accomplishment Of Protected Infrastructure In Disseminated RFID Systems

: Privacy protection is the primary concern when RFID applications are deployed in our daily lives. Due to passive tags that are computationally weak, the non-encryption-based simulation protocols have been recently developed, in which wireless jamming is used. However, the existing private tag access protocols without sharing secrets depends on impractical assumptions hence difficult to deploy. To tackle this issue we redesign RFID architecture by dividing RFID reader into an RF activator and Trusted Shield Device (TSD). Then we proposed new coding scheme namely Random Flipping Random Jamming (RFRJ), to protect the tags contents. Analysis and simulation results validate our distributed architecture with the RFRJ coding scheme, which protects tag’s privacy against various adversaries like encoding collision, random guessing attack, correlation attack, eavesdropping, and ghost and leech attack.
IMPACT OF SERUM URIC ACID CONCENTRATION ON ULTRASOUND SCANNED PREGNANT WOMEN IN CALABAR, NIGERIA

Objectives: To evaluate the effect of serum uric acid elevation on the fetus and to determine the existence of a connection between hyperuricemia and gestational hyperten sion (pre-eclampsia). Materials and method: A prospective cross-sectional case-controlled ultrasound scan study was done on 200 singleton pregnant women between 20 to 40 weeks gestational age in a 12-month period. The age range for the cases and control were from 15 to 39 years. Uric acid concentration in the serum obtained from all the women was analyzed utilizing manual colorimetric method. Pearson’s correlation and the student t-tests were used to analyze the data obtained. Results : Maternal serum uric acid had negative correlation with fetal heart rate (FHR) (p = 0.025) and a positive correlation with estimated gestational age (EGA) (p = 0.040) including estimated fetal weight EFW (p = 0.046). A significant positive correlation between uric acid and proteinuria (p = 0.009) was observed. Uric acid was higher in pre-eclamptics than gestational hypertensives (8.528±2.679 mg/dl versus 6.542±1.746 mg/dl, p = 0.016). Also, uric acid in pregnancy induced hypertension (PIH) was higher than the normotensives (7.535±2.165 mg/dl versus 5.437±1.636 mg/dl). Conclusion : Maternal hyperuricemia predisposes to fetal bradycardia which may have possibly led to the two fetal demise recorded in the present study. Increased EFW with hyperuricemia may be due to higher body mass index (BMI) of the subjects. Therefore, high serum uric acid has a significant role in foretelling the appearance of preeclampsia but not gestational hypertension.
A Ca 2 (cid:49) -induced Ca 2 (cid:49) Release Mechanism Involved in Asynchronous Exocytosis at Frog Motor Nerve Terminals

The extent to which Ca 2 (cid:49) -induced Ca 2 (cid:49) release (CICR) affects transmitter release is unknown. Continuous nerve stimulation (20—50 Hz) caused slow transient increases in miniature end-plate potential (MEPP) frequency (MEPP-hump) and intracellular free Ca 2 (cid:49) ([Ca 2 (cid:49) ] i ) in presynaptic terminals (Ca 2 (cid:49) -hump) in frog skeletal muscles over a period of minutes in a low Ca 2 (cid:49) , high Mg 2 (cid:49) solution. Mn 2 (cid:49) quenched Indo-1 and Fura-2 fluorescence, thus indicating that stimulation was accompanied by opening of voltage-dependent Ca 2 (cid:49) channels. MEPP-hump depended on extracellular Ca 2 (cid:49) (0.05—0.2 mM) and stimulation frequency. Both the Ca 2 (cid:49) - and MEPP-humps were blocked by 8-( N,N -diethylamino)octyl3,4,5-trimethoxybenzoate hydrochloride (TMB-8), ryanodine, and thapsigargin, but enhanced by CN (cid:50) . Thus, Ca 2 (cid:49) -hump is generated by the activation of CICR via ryanodine receptors by Ca 2 (cid:49) entry, producing MEPP-hump. A short interruption of tetanus ( (cid:44) 1 min) during MEPP-hump quickly reduced MEPP frequency to a level attained under the effect of TMB-8 or thapsigargin, while resuming tetanus swiftly raised MEPP frequency to the previous or higher level. Thus, the steady/equilibrium condition bal-ancing CICR and Ca 2 (cid:49) clearance occurs in nerve terminals with slow changes toward a greater activation of CICR (priming) during the rising phase of MEPP-hump and toward a smaller activation during the decay phase. A short pause applied after the end of MEPP- or Ca 2 (cid:49) -hump affected little MEPP frequency or [Ca 2 (cid:49) ] i , but caused a quick increase (faster than MEPP- or Ca 2 (cid:49) -hump) after the pause, whose magnitude increased with an increase in pause duration ( (cid:44) 1 min), suggesting that Ca 2 (cid:49) entry-dependent inactivation, but not depriming process, explains the decay of the humps. The depriming process was seen by giving a much longer pause ( (cid:46) 1 min). Thus, ryanodine receptors in frog motor nerve terminals are endowed with Ca 2 (cid:49) entry-dependent slow priming and fast inactivation mechanisms, as well as Ca 2 (cid:49) entry-dependent activation, and involved in asynchronous exocytosis. Physiological significance of CICR in presynaptic terminals was discussed.
Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma

Purpose: Dioscin, a natural glycoside derived from many plants, has been proved to exert anti-cancer activity. Several studies have found that it reverses TGF- β 1-induced epithelial – mesenchymal transition (EMT). Whether dioscin can reverse EMT by pathways other than TGF- β is still unknown. Methods: We used network-based pharmacological methods to systematically explore the potential mechanisms by which dioscin acts on lung cancer. Cell Counting Kit-8 assay, scratch healing, Transwell assay, Matrigel invasion assay, immuno ﬂ uorescence assay, and Western blotting were employed to con ﬁ rm the prediction of key targets and the effects of dioscin on EMT. Results: Here, using network-based pharmacological methods, we found 42 possible lung cancer-related targets of dioscin, which were assigned to 98 KEGG pathways. Among the 20 with the lowest p-values, the PI3K-AKT signaling pathway is involved and signi ﬁ cantly related to EMT. AKT1 and mTOR, with high degrees (re ﬂ ecting higher connectivity) in the compound-target analysis, participate in the PI3K-AKT signaling pathway. Molecular docking indicated the occur-rence of dioscin-AKT1 and dioscin-mTOR binding. Functional experiments demonstrated that dioscin suppressed the proliferation, migration, invasion, and EMTof human lung adenocarcinoma cells in a dose-dependent manner, without TGF- β stimulation. Furthermore, we determined that dioscin downregulated p-AKT, p-mTOR and p-GSK3 β in human lung adenocarcinoma cells without affecting their total protein levels. The PI3KinhibitorLY294002 augmented these changes. Conclusion: Dioscin suppressed proliferation, invasion and EMT of lung adenocarcinoma cells via the inactivation of AKT/mTOR/GSK3 β signaling, probably by binding to AKT and mTOR, and inhibiting their phosphorylation.
About an Immune System Understanding for Cloud-native Applications Biology Inspired Thoughts to Immunize the Cloud Forensic Trail

—There is no such thing as an impenetrable system, although the penetration of systems does get harder from year to year. The median days that intruders remained undetected on victim systems dropped from 416 days in 2010 down to 99 in 2016. Perhaps because of that, a new trend in security breaches is to compromise the forensic trail to allow the intruder to remain undetected for longer in victim systems and to retain valuable footholds for as long as possible. This paper proposes an immune system inspired solution, which uses a more frequent regeneration of cloud application nodes to ensure that undetected compromised nodes can be purged. This makes it much harder for intruders to maintain a presence on victim systems. Basically, the biological concept of cell-regeneration is combined with the information systems concept of append-only logs. Evaluation experiments performed on popular cloud service infrastructures (Amazon Web Services, Google Compute Engine, Azure and OpenStack) have shown that between 6 and 40 nodes of elastic container platforms can be regenerated per hour. Even a large cluster of 400 nodes could be regenerated in somewhere between 9 and 66 hours. So, regeneration shows the potential to reduce the foothold of undetected intruders from months to just hours.
Modeling and Simulation Versions of Business Process using Petri Nets

— This paper proposes a solution for modeling and simulating flexible Business Processes (BP) using version concepts. It advocates a Model Driven Architecture approach to handle versions of BP. The paper presents, first, a meta model (VBP2M: Versioned Business Process Meta model) for modeling versions of BP considering six perspectives of business processes: process, functional, operation, informational, organizational and intentional perspectives. Then, it proposes an extension of the meta model of Petri nets (PN) to support the version concepts. Finally, it defines mapping rules to translate versions of BP modeled in accordance with the VBP2M to PN models, with graphical representations, in order to be able to simulate the behavior of each version of BP.
Robots Hiper-Redundantes: Clasificación, Estado del Arte y Problemática

Los robots hiper-redundantes son aquellos que tienen un número muy elevado de grados de libertad. En su uso cotidiano, la redundancia es referida para indicar una repetición o un uso excesivo de un concepto. En el campo de la robótica, la redundancia puede ofrecer numerosos beneficios frente a los robots convencionales. Los robots hiper-redundantes poseen una mayor habilidad para sortear obstáculos, son tolerantes a fallos en algunas de sus articulaciones y también pueden ofrecer ventajas cinemáticas. En este artículo se presentan los conceptos generales para entender este tipo de robots, así como una clasificación de los mismos, su potencial, su problemática y su evolución a lo largo de la historia.
Flexible Process Modeling Determined by Existing Human Expert Domain Knowledge Bases

— The evaluation of final workpiece properties at process end can be realized by process modeling instead of destructive testing methods. In this paper, we give an overview about different modeling strategies. They are focused on the amount of available domain knowledge. White box models try to model the reality by physical principles and black box models are mainly data driven. Grey box models are hybrid variants. The different strategies are applied to the domain of resistance spot welding. The proposed approaches are able to improve the quality of resistance spot welding.
DIABETES MELLITUS AND HYPERTENSION: A PROSPECTIVE COMMUNITY-BASED STUDY

Objective: To evaluate the current prevalence and distribution of diabetes and hypertension and their relationship within the Studied people. Methods: Door-to-door population based survey work was conducted to collect data regarding diabetes and hypertension and their associated risk factors (sociodemographic and biochemical) from 2,453 members of households of studied people. Blood samples were collected from 114 willing participants for the biochemical analysis. Data were analyzed using chi-square test at both 2.5% and 5% level of significance. Results: Overall crude prevalence of hypertension was 15.85% in studied people. Male (17.43%) showed a higher hypertensive rate than female (14.35%). The rate of hypertension in diabetic (47.37%) patients was very high in comparison to non-diabetic (22.10%) group of people. Mean BP (SBP/DBP) in diabetic and non-diabetic subjects were 139.52/92.36 mmHg and 118.34/81.26 mmHg respectively. Significant increase of both SBP (p<0.01) and DBP (p<0.05) were observed in diabetic subjects in contrast to non diabetic group of people. Chi-square test revealed that there was a significant (p<0.025) increase of hypertension in diabetic group of people. Conclusions: The results indicate that the hypertension as well as blood pressure was significantly associated with diabetes.
Case Fatality Rate and Some Demographic Characteristics Among Children in Al- Elwyia Pediatric Teaching Hospital During Influnza Pandemic 2009

Background: Influenza A (H1N1) virus is the subtype of influenza A virus that was the most common cause of human influenza (flu) in 2009. Other strains of H1N1 are endemic in pigs (swine influenza) and in birds (avian influenza). In June 2009, the World Health Organization declared the new strain of swine-origin H1N1 as a pandemic. This strain is often called swine flu by the public media. Aim : This study was designed to know case fatality rate and some demographic characters during 2009 influnza pandemic among children in Al- Elwyia teaching hospital Baghdad Iraq. Methods : Cross sectional study of 342 cases with signs and symptoms of influenza were studied. Samples were tested with real time polymerase chain reaction (PCR) . Results : Case fatality rate was estimated to be 0.5% . Males and the age group of 6-12years age group are predominantly affected with pandemic influenza. Conclusion : Pediatric H1N1 case fatality rate is comparable to national and global case fatality rate.
Chronic heart failure management: Novelties and perspectives (Part I)

Chronic heart failure (HF) is the important medical and social problem due its high mortality and treatment cost. Despite improvements in outcomes in the last few decades for HF, there still remains a need for novel therapies as many patients incompletely recover with existing therapies and progress to advanced HF. In this review, we will discuss recent advances in the management of HF with a focus on upcoming therapies that hold the greatest promise for clinical use.
CIA_A_273934 2019..2029

1College of Nursing, Ewha Womans University, Seoul, South Korea; 2School of Nursing, Duke University, Durham, NC, USA; 3Weill Cornell Medicine, New York, NY, USA; 4Department of Comics and Animation Technology, Sejong University, Seoul, South Korea Purpose: The purpose of this study was to assess the feasibility and examine the preliminary effectiveness of a mobile application-based meal assistant training program (APP) for use by direct care workers (CAs) assisting residents with dementia in long-term care facilities in South Korea. Methods: We adopted a mixed methods research design, which included a preand postintervention study and focus group interviews for the feasibility assessment. Participants included 23 dyads of older adults with dementia and their CAs from a long-term care facility in South Korea. Upon completion of the APP intervention, focused group interviews were conducted with six CAs and five nurses. Results: The results of paired t-tests showed that the effects of the APP intervention on the older adults with dementia and their CAs were not significant; however, the results of the focused group interviews support the potential usefulness of the APP for CAs. Conclusion: The APP may be applicable to long-term care workers who need meal assistant skills education.