Miracle-dz/UniFAR-FTUs huggingface dataset:
PARASITES OF AN ENDANGERED HARVEST MOUSE (REITHRODONTOMYS RAVIVENTRIS HALICOETES) IN A NORTHERN CALIFORNIA MARSH

Abstract: Disease may limit recovery of endangered species. We surveyed parasites in the federally endangered salt marsh harvest mouse (SMHM; Reithrodontomys raviventris halicoetes) and sympatric rodents in Suisun Marsh (Solano County, California, USA) from April 2018 through March 2019. We investigated individual SMHM risk factors (age, sex, reproductive status, and body condition) for infection and relationships among the estimated parasite prevalence and season and habitat management (natural tidal habitats versus diked, nontidal habitats). We captured 625 individual rodents, including 439 SMHM, and tested these for infection with Bartonella spp. , Borrelia spp. , Rickettsia spp. , Francisella tularensis, Leptospira spp. , Cryptosporidium spp. , Giardia spp. , and Toxoplasma gondii by PCR. Over one-third (34.6%, confidence interval [CI], 30.2–39.3%) of SMHM tested positive for at least one parasite. Four percent (CI, 2.8–6.3%) of SMHM were infected with F. tularensis holarctica, a virulent bacterium that causes mortality in rodents shortly after infection. Additionally, we detected three species of Bartonella (B. henselae, B. rochalimae, B. vinsonii arupensis), Leptospira borgpetersenii serovar Ballum, Cryptosporidium sp. (deer mouse [Peromyscus maniculatus] genotype), Cryptosporidium parvum, Giardia intestinalis, and an unidentified Borrelia sp. The only parasite that was associated with habitat management was Bartonella spp. , which was more prevalent in diked than tidal areas. Male SMHM were more likely to be parasitized than females, and individuals in modestly poor body condition were most likely to be infected with Bartonella spp. The estimated sample prevalence of multiple parasites varied by season and by host species. This is the first major parasite assessment in a long-endangered species, and these results will assist managers to incorporate parasitic disease into recovery planning and provide a critical baseline for future investigations, including how climatically induced habitat and species composition changes could alter disease dynamics.
The system of manufacturing : a prospective study

A regenerative motor control of the field reversing type includes a field circuit for energizing the motor field and an armature circuit for energizing the motor armature. An analog signal generating means, typically a multiplier, is coupled to the armature circuit and is operable by a bi-polarity motor operative condition error signal and a bi-polarity field current direction and magnitude signal for energizing the motor armature and for providing deenergization, as well as improved reenergization of the armature, during the transient period between motoring and regenerative operation.
Ephone: embedded cardiac care device in mobile phone

A novel device, named EPhone, developed for rural doctor diagnosing and/or patient monitoring is presented. This device is embedded in a mobile phone and includes amplifier circuit, filter circuit, a microcontroller, a data management, etc. The heart rate, the ST segment deviation and the premature ventricular beats rate are computed insided phone and a normality limit is set for each one. When one of these limits is reached, an ECG strip is transmitted to the Three-level Healthcare Network in Rural China (THNRC) via 2G mobile phones and the device waits to display the receiving answer. The methods used to analyze the ECG were tested with real ECGs and all the QRS complexes were detected. Since many of the users are rural doctors and technically skilled, and it is of paramount importance that the device is very convenient to carry. This has been achieved by providing embedded device and displaying unambiguous messages on a screen of mobile phone. When the communication process was tested, a remarkable difference between the transmitting and receiving signals was not observed.
Association of Systolic and Diastolic Blood Pressure With All-Cause Mortality Among Community-Dwelling Older Adults: A Prospective Observational Study

Objectives To assess the association of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with mortality among older adults in Singapore. Methods Association of SBP and DBP measured in 2009 for 4443 older adults (69.5±7.4 years; 60–97 years) participating in a nationally representative study with mortality risk through end-December 2015 was assessed using Cox regression. Results Higher mortality risk was observed at the lower and upper extremes of SBP and DBP. With SBP of 100–119 mmHg as the reference, multivariable mortality hazard ratios [HRs (95% confidence interval)] were SBP <100 mmHg: 2.41 (1.23–4.72); SBP 160–179 mmHg: 1.51 (1.02–2.22); and SBP ≥180 mmHg: 1.78 (1.12–2.81). With DBP of 70–79 mmHg as the reference, HRs were DBP <50 mmHg: 2.41 (1.28–4.54) and DBP ≥110 mmHg: 2.16 (1.09–4.31). Discussion Management of high blood pressure among older adults will likely reduce their mortality risk. However, the association of excessively low SBP and DBP values with mortality risk needs further evaluation.
55.4: Design of Integrated a‐Si Gate Driver Circuits for Low Power Consumption

We have developed integrated a‐Si:H TFT gate driver circuits on large area TFT‐LCD for low power solution. The proposed driving scheme achieves 40% lower power consumption than that of a conventional a‐Si:H TFT gate drivers by means of double 2‐phase clock system. We have redesigned a‐Si:H gate driver circuit and made the proto type 13.3″WXGA panel.
Cyclin-dependent Kinase 4/6 Inhibitor Palbociclib in Combination with Ralaniten Analogs for the Treatment of Androgen Receptor–positive Prostate and Breast Cancers

Androgen receptor (AR) has essential roles in the growth of prostate cancer and some breast cancers. Inhibition of AR transcriptional activity by targeting its N-terminal domain with ralaniten or an analog such as EPI-7170 causes accumulation of cells in the G1-phase of the cell cycle. Inhibition of cyclin-dependent kinases 4/6 with palbociclib also leads to accumulation of cells in the G1-phase. Here, a combination of EPI-7170 with palbociclib attenuated the in vivo growth of human castration-resistant prostate cancer xenografts that are resistant to antiandrogens. Cell-cycle tracing experiments in cultured cells revealed that EPI-7170 targeted cells in the S-phase, possibly through inducing DNA damage or impairing the DNA damage response, whereas palbociclib targeted the G1–S transition to delay the cell cycle. Combination treatment prevented cells in G1 and G2–M from progressing in the cell cycle and caused a portion of cells in the S-phase to arrest, which contributed to a twofold increase in doubling time to >63 hours compared with 25 hours in control cells. Importantly, sequential combination treatments with palbociclib administered first then followed by EPI-7170, resulted in more cells accumulating in G1 and less cells in the S-phase than concomitant combination which was presumably because each inhibitor has a unique mechanism in modulating the cell cycle in cancer cells. Together, these data support that the combination therapy was more effective than individual monotherapies to reduce tumor growth by targeting different phases of the cell cycle.
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Association of Differential Mast Cell Activation to Granulocytic Inflammation in Severe Asthma.

BACKGROUND Mast cells (MC) play a role in inflammation and both innate and adaptive immunity but their involvement in severe asthma (SA) remains undefined. OBJECTIVE We investigated the phenotypic characteristics of the U-BIOPRED asthma cohort by applying published MC activation signatures to the sputum cell transcriptome. METHODS 84 SA, 20 mild/moderate (MMA) asthma, and 16 non-asthmatic healthy participants were studied. We calculated enrichment scores (ES) for nine MC activation signatures by asthma severity, sputum granulocyte status and three previously-defined sputum molecular phenotypes or transcriptome-associated clusters (TAC1, 2, 3) using gene-set variation analysis. RESULTS MC signatures except unstimulated, repeated FcεR1-stimulated and IFNγ-stimulated were enriched in SA. A FcεR1-IgE-stimulated and a single cell signature from asthmatic bronchial biopsies were highly enriched in eosinophilic asthma and in the TAC1 molecular phenotype. Subjects with a high ES for these signatures had elevated sputum levels of similar genes and pathways. IL-33- and LPS-stimulated MC signatures had greater ES in neutrophilic and mixed granulocytic asthma and in the TAC2 molecular phenotype. These subjects exhibited neutrophil, NF-κB, and IL-1β/TNFα pathway activation. The IFNγ-stimulated signature had the greatest ES in TAC2 and TAC3 that was associated with responses to viral infection. Similar results were obtained in an independent ADEPT asthma cohort. CONCLUSIONS Gene signatures of MC activation allow the detection of SA phenotypes and indicate that MC can be induced to take on distinct transcriptional phenotypes associated with specific clinical phenotypes. IL-33-stimulated MCs signature was associated with severe neutrophilic asthma while IgE-activated MC with an eosinophilic phenotype.
High-speed octave band digital filtering

A method for very fast nonrecursive digital filtering is presented in which over three fourths of the coefficients of the filter impulse response are forced to be zero by the judicious choice of filter center frequency, bandwidth, and window. Nearly half of the remaining coefficients can be discarded by taking advantage of the symmetry of the impulse response, A technique is described for separating a signal into octave bands using the same set of coefficients for each filter operation provided that either the data is "decimated" or the impulse response is "stretched" prior to each pass. Timing comparisons show that this method is faster than Radix 2 FFT convolution using filters with up to 300 coefficients. For many applications, real-time filtering can be achieved by using fixed-point arithmetic and an impulse response having as few as seven nonzero values.
Pipeline for Development of 3 Dimensional motion animation using the 2 Dimensional video

The main idea of this project is to propose an efficient set of techniques to perform the process of motion capture. Motion capture is basically a process of capturing the motion of a person and using it to transfer it to a 3D model created to the user’s desire. The process basically obtains this motion by making the actor wear a motion capture suit which contains markings on their body joints and the changes in the position of these markers are used to obtain the motion. This project has established a set of techniques to make this process easier and cost-efficient. Fabricating a mobile robot that can follow the actor and record the video by keeping him in the required position in the video frame. Then the recorded video is inputted to several deep learning models which in turn can give us the 3D pose of the actor. This motion can be transferred to the required 3D model. Thus, avoiding the use of the mocap suit and multiple cameras to get the motion from the actor.
Utility of the Pediatric Bleeding Questionnaire in Predicting Posttonsillectomy Bleeding

Objective Posttonsillectomy bleeding is a dreadful complication that may be life-threatening. Preoperative coagulation tests have not been shown to be effective in predicting this complication. The Pediatric Bleeding Questionnaire (PBQ) is a validated and sensitive tool in diagnosing children with abnormal hemostatic functions, and the objective of our study was to assess its utility as a preoperative screening tool for predicting posttonsillectomy bleeding. Study Design Prospective single-blinded cohort study. Setting Tertiary care hospital system. Methods All children scheduled for tonsil surgery between 2017 and 2019 in the Galilee Medical Center were included. The PBQ was completed by the caregivers prior to surgery, and all children underwent coagulation tests. Each PBQ item is scored on a scale of −1 to 4, and the total score per candidate is based on summation of all items. Results An overall 272 patients were included in the study with a mean age of 5.2 years; 57.7% were boys. The main finding was that in a multivariable model adjusted to age, a PBQ score of 2 is correlated with increased postoperative bleeding risk (odds ratio, 10.018 [95% CI, 1.20-82.74]; P = .046). The results of the PBQ demonstrated better predictive ability when compared with abnormal coagulation test results (odds ratio, 1.76 [95% CI, 0.63-4.80]; P = .279). Sex was not found to be significant (odds ratio, 1.45 [95% CI, 0.70-3.18]; P = .343). Conclusions This study demonstrated that a PBQ score ≥2 has a higher yield for detecting children at risk for posttonsil surgery bleeding as compared with coagulation studies.
Enhanced heterostructure field effect transistor CAD model suitable for simulation of mixed mode circuits

We describe a new enhanced model for deep submicron heterostructure field effect transistors (HFET's) suitable for implementation in computer aided design (CAD) software packages such as SPICE. The model accurately reproduces both above-threshold and subthreshold characteristics of both n- and p-channel deep submicron HFET's over the temperature range 250-450 K. The current-voltage (I-V) characteristics are described by a single, continuous, analytical expression for all regimes of operation, thereby improving convergence. The physics-based model includes effects such as velocity saturation in the channel, drain-induced barrier lowering (DIBL), finite output conductance in saturation, frequency dispersion, and temperature dependence. The output resistance and the transconductance are accurately reproduced, making the model suitable for simulation of mixed mode (digital/analog) circuits. The model has been extensively verified against experimental data for two HFET technologies with gate lengths down to 0.3 /spl mu/m.
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR

Supplemental Digital Content is available in the text. Background: The sarcoplasmic reticulum (SR) Ca2+-ATPase 2 (SERCA2) mediates Ca2+ reuptake into SR and thereby promotes cardiomyocyte relaxation, whereas the ryanodine receptor (RYR) mediates Ca2+ release from SR and triggers contraction. Ca2+/CaMKII (CaM [calmodulin]-dependent protein kinase II) regulates activities of SERCA2 through phosphorylation of PLN (phospholamban) and RYR through direct phosphorylation. However, the mechanisms for CaMKIIδ anchoring to SERCA2-PLN and RYR and its regulation by local Ca2+ signals remain elusive. The objective of this study was to investigate CaMKIIδ anchoring and regulation at SERCA2-PLN and RYR. Methods: A role for AKAP18δ (A-kinase anchoring protein 18δ) in CaMKIIδ anchoring and regulation was analyzed by bioinformatics, peptide arrays, cell-permeant peptide technology, immunoprecipitations, pull downs, transfections, immunoblotting, proximity ligation, FRET-based CaMKII activity and ELISA-based assays, whole cell and SR vesicle fluorescence imaging, high-resolution microscopy, adenovirus transduction, adenoassociated virus injection, structural modeling, surface plasmon resonance, and alpha screen technology. Results: Our results show that AKAP18δ anchors and directly regulates CaMKIIδ activity at SERCA2-PLN and RYR, via 2 distinct AKAP18δ regions. An N-terminal region (AKAP18δ-N) inhibited CaMKIIδ through binding of a region homologous to the natural CaMKII inhibitor peptide and the Thr17-PLN region. AKAP18δ-N also bound CaM, introducing a second level of control. Conversely, AKAP18δ-C, which shares homology to neuronal CaMKIIα activator peptide (N2B-s), activated CaMKIIδ by lowering the apparent Ca2+ threshold for kinase activation and inducing CaM trapping. While AKAP18δ-C facilitated faster Ca2+ reuptake by SERCA2 and Ca2+ release through RYR, AKAP18δ-N had opposite effects. We propose a model where the 2 unique AKAP18δ regions fine-tune Ca2+-frequency-dependent activation of CaMKIIδ at SERCA2-PLN and RYR. Conclusions: AKAP18δ anchors and functionally regulates CaMKII activity at PLN-SERCA2 and RYR, indicating a crucial role of AKAP18δ in regulation of the heartbeat. To our knowledge, this is the first protein shown to enhance CaMKII activity in heart and also the first AKAP (A-kinase anchoring protein) reported to anchor a CaMKII isoform, defining AKAP18δ also as a CaM-KAP.
The Impact of Changes in Work Arrangements During COVID-19 Pandemic on the Lifestyle of Qatar's Working Population

Supplemental Digital Content is available in the text Working from home might become the “new normal” or it might be imposed during any public health crises or potential future outbreaks. Thus, organizations need to adapt their polices and rules to fit this new work environment in a way that ensures the health, wellbeing, and safety of their employees. Objectives: To explore the impact of changing work arrangements during COVID-19 on diet, physical activity, body weight, and sleep of Qatar's working population. Methods: A web-based survey targeting working adults who were residing in Qatar during the period of home confinement was conducted. Results: About 47% of 1061 participants reported weight gain. Higher proportions of participants reported consuming more fatty foods (P = 0.007), more sugary foods (P = 0.001), and greater increase in screen and sitting/reclining times (P < 0.001) among the work from home (WFH) group. Participants with higher adverse dietary changes score were more likely to report weight gain in both the WFH (adjusted OR 1.38, 95% CI 1.28 to 1.49), and working regularly groups (adjusted OR, 1.31, 95% CI 1.20 to 1.43) with P < 0.001. Conclusion: Qatar's working population experienced adverse lifestyle changes which were more prominent among those who shifted to WFH.
Methodological Reconciliation of CP and MLSS and Their Agreement with the Maximal Metabolic Steady State

ABSTRACT The critical power (CP) and maximal lactate steady state (MLSS) are operational surrogates of the maximal metabolic steady state (MMSS). However, their concordance and their agreement with MMSS remain variable likely because of methodological factors. Purpose This study aimed to compare the concordance between CP and MLSS estimated by various models and criteria and their agreement with MMSS. Methods After a ramp test, 10 recreationally active males performed four to five severe-intensity constant-power output (PO) trials to estimate CP and three to four constant-PO trials to determine MLSS and identify MMSS. CP was computed using the three-parameter hyperbolic (CP3-hyp), two-parameter hyperbolic (CP2-hyp), linear (CPlin), and inverse of time (CP1/Tlim) models. In addition, the model with the lowest combined parameter error identified the “best-fit” CP (CPbest-fit). MLSS was determined as an increase in blood lactate concentration ≤1 mM during constant-PO cycling from the 5th (MLSS5–30), 10th (MLSS10–30), 15th (MLSS15–30), 20th (MLSS20–30), or 25th (MLSS25–30) to 30th minute. MMSS was identified as the greatest PO associated with the highest submaximal steady-state V˙O2 (MV˙O2ss). Results Concordance between the various CP and MLSS estimates was greatest when MLSS was identified as MLSS15–30, MLSS20–30, and MLSS25–30. The PO at MV˙O2ss was 243 ± 43 W. Of the various CP models and MLSS criteria, CP2-hyp (244 ± 46 W) and CPlin (248 ± 46 W) and MLSS15–30 and MLSS20–30 (both 245 ± 46 W), respectively, displayed, on average, the greatest agreement with MV˙O2ss. Nevertheless, all CP models and MLSS criteria demonstrated some degree of inaccuracies with respect to MV˙O2ss. Conclusions Differences between CP and MLSS can be reconciled with optimal methods of determination. When estimating MMSS, from CP the error margin of the model estimate should be considered. For MLSS, MLSS15–30 and MLSS20–30 demonstrated the highest degree of accuracy.
Robust synthesis of dispersive mirrors

The robust synthesis based on simultaneous optimization of reflectivity of multiple designs located in a small neighborhood of a pivotal design is presented. Efficiency of this technique is demonstrated by the synthesis and successful experimental realization of two types of high dispersive mirror. The first type of fabricated dispersive mirror covers 690-890 nm wavelength range and provides the dispersion of -300 fs2 at 800 nm. We perform 4 independent coating runs to proof reliability of robust design method. The second type of mirror provides -4500 fs2 of group delay dispersion in wavelength range 1027-1033 nm.
Harmonic Response Analysis of Multi-Storey Building

For high rise structures depending upon the precision required and limit state considered an engineer shall perform response analysis with suitable idealization for loading and geometry of the structure. The structural response for wind loads can be made more realistic by assuming wind loads as harmonic instead of quasi static approaches of equivalent static loads. Any sustained cyclic load produces a harmonic response in the building. When the natural frequency of a multi storey building matches the frequency of forcing excitations resonance occurs causing maximum displacement. In the present context, Harmonic response technique is then adopted on ANSYS platform for a fifteen storey structure bare frame and employing mode superposition method displacements of the structure at various floor levels are evaluated. Peak displacement is then visualized from the frequency v/s displacement graph obtained from mode superposition of reduced modes at forcing frequencies.