Miracle-dz/UniFAR-FTUs huggingface dataset:
Title: A genome-scale atlas reveals complex interplay of transcription and translation in 1 an archaeon 2

26 The scale of post-transcriptional regulation and the implications of its interplay with other forms of 27 regulation on environmental acclimation is underexplored for organisms of the domain Archaea. 28 Here, we have investigated the scale of post-transcriptional regulation in the extremely halophilic 29 archaeon Halobacterium salinarum NRC-1 by integrating transcriptome-wide locations of 30 transcript processing sites (TPS) and SmAP1 binding, genome-wide locations of antisense RNAs 31 (asRNAs), and consequences of RNase_2099C knockout on differential expression of all genes. 32 This integrated analysis has discovered that 54% of all protein-coding genes in the genome of 33 this haloarchaeon are likely targeted by multiple mechanisms for putative post-transcriptional 34 processing and regulation, with about 20% of genes likely regulated by combinatorial schemes 35 involving SmAP1, asRNAs, and RNase_2099C. Comparative analysis of mRNA levels (RNA- 36 Seq) and protein levels (SWATH-MS) for 2,579 genes over four phases of batch culture growth 37 in complex medium has generated additional evidence for conditional post-transcriptional 38 regulation of 7% of all protein-coding genes. We demonstrate that post-transcriptional regulation 39 may act to fine-tune specialized and rapid acclimation to stressful environments, e.g., as a switch 40 to turn on gas vesicle biogenesis to promote vertical relocation in anoxic conditions and to 41 modulate frequency of transposition by IS elements of the IS 200 /IS 605 , IS 4 , and IS H3 families. 42 Findings from this study are provided as an atlas
Continuous ﬂuorescence recording as a way to improve Paciﬁc oyster (Crassostrea gigas) models of paralytic shellﬁsh toxin accumulation

– A simple system was used to simulate the e ﬀ ect of alternating toxic (paralytic shellﬁsh poisoning toxins) and non-toxic microalgal diets on oyster feeding behaviors and rates of toxin accumulation. These experimental conditions were meant to reﬂect, to some extent, the incoming and outgoing ﬂuxes of toxic algae observed at the mouth of the Penzé estuary (Northern Brittany, France). Physiological and toxicological parameters were estimated based on ﬂuorescence measurements recorded continuously at the outlet of each experimental tank, which contained a single oyster. Q tox , this variable describes toxin uptake in oysters, it was used (instead of the toxin ingestion rate): i) in simple graphical analyses, ii) as well as in one- and two-compartment models. Results show that toxin uptake varies widely from one individual to another and is not proportional to the concentration of toxic algae in sea water. A one-compartment model with individual ﬂuorescence recordings as “input” data gave questionable results, however, a two-compartment model was found to e ﬀ ectively describe contamination kinetics in oysters. Limitations of this model as well as possible improvements are discussed.
Predicting Transfer in a Game-Based Adaptive Instructional System

Transfer, the application of knowledge to new problem-solving situations, and preparation for future learning are often considered among the primary goals of education, but it is difficult to achieve. This paper presents an initial exploration of young children’s ability to transfer the specific knowledge and skills that they have learned from a game-based adaptive instructional system to the types of math problems they typically see in school. We describe a regression tree model predicting young children’s far transfer performance of specific knowledge and skills following their performance in a game-based adaptive instructional system called My Math Academy . Findings suggest that My Math Academy game-play empirically supports positive performance on a task that involves elements of both far transfer of learning and preparation for future learning.
SELF BALANCING OF BATTERY CELLS AND PV ARRAYS: A REAL-TIME PHYSICAL VALIDATION

This thesis shows, experimentally, that the direct connection of photovoltaic arrays and battery cells can achieve self-balancing by design. This work is motivated by the potential of such self-balancing to reduce overall battery pack cost by eliminating the need for active balancing circuitry. Previous literature proves this self-balancing property mathematically using simple battery and photo-voltaic cell models. The literature also demonstrates self-balancing using both software-and hardware-in-the-loop simulations. In contrast, the goal of this paper is to demonstrate self-balancing through a physical experimental setup. The setup is successful in balancing battery states of charge. However, compared to the exist-ing systems, the self-balancing setup achieves this goal without requiring active equalization circuits.
Nexus Between Risk in Outsourced Activities and Operational Performance of Electricity Distribution Company in Nigeria

The emergence of globalization has made outsourcing become one of the most used corporate strategies for providing top‐notch services to various service industry which the electricity distribution sector is not left out. The study aims at examining the outsourced risk and operational performance of electricity distribution company in Nigeria using Benin Electricity Distribution Company (BEDC) as a case study. The study employed survey research design with a sample size of 14 business managers who were selected purposively. The data collected were analyzed using correlation analysis to determine the risk inherent outsourced activities posed are associated with operational performances. The findings of the study shows that the Pearson correlation value r = 0.333 between security & privacy risk and operational performance indicates a positive and low relationship at (P=0.245; P>0.05) significant level, the Pearson correlation value r = 0.311 between operational risk and operational performance indicates a positive and low relationship at (P=0.279; P>0.05) significant level , and the Pearson correlation value r = 0.543 between financial risk and operational performance indicates a positive and moderate at (P=0.045; P<0.05) significant level in the study area. In line with the findings, the study concludes that all risks factors are contributing element to operational performance except for financial risk having a moderate influence on operational performance in the study area and recommends that as much as risk is an important factor in business, the services of outsourced vendors should be cautioned so as not to expose the organization to too much of risk.
Identification of Metallo-ß-Lactamase Inhibitors via Enzyme Assay and HPLC-MS Monitoring

The vast overuse of antibiotics along with extrachromosomal gene insertion between different bacterial species has led to the Darwinian consequence of antibiotic resistance. Amongst the contributing factors to the rise of bacterial resistances are the production of |3-lactamases, which pose a major impediment to treatment with (3-lactam drugs such as penicillins and carbapenems. SPM-1 is a metallo-(3-lactamase (MBL) that confers antibiotic resistance to bacteria through zinc-mediated hydrolysis of (3-lactams. Bacteria that express the SPM-1 metalloenzyme show reduced sensitivity to P-lactam drugs. One method to defeat this form of resistance is to administer a (3-lactam antibiotic with a potent (3-lactamase inhibitor as a combination therapy. The administration of clavulanic acid with amoxicillin, marketed as Augmentin'TM, has proven to be clinically successful against serine-based (3-lactamases. The introduction of new inhibitors can reinstall the use of now currently ineffective antibiotics. Natural products are a source of structurally diverse therapeutics preselected by evolution for potent activity. The coevolution of metallo-(3-lactamases and bacteria has already been shown to have produced several natural product inhibitors of the enzymes and the screening of natural product extracts is a promising source of metallo-(3-lactamase inhibitors. Due to the complexity and highly absorptive properties of natural product extracts, many screening techniques including UV-VIS spectrophotometry are incapable of detecting inhibitors in extract with any selectivity or sensitivity. Following the separation of extract components by techniques such as high performance liquid chromatography (HPLC), metallo-(3-lactamase inhibitors can be screened for higher selectively at micromolar concentrations.
On the Farrell-Jones Isomorphism Conjecture

In this thesis, we study three different aspects of the Farrell-Jones Conjecture (FJC). The first is the study of the conjecture for groups admitting nice but not necessarily proper actions on CAT(0)-spaces (stabilizers can be infinite). It is a natural question that if the point stabilizers of the action satisfy the conjecture, whether the original group satisfies the conjecture. For this, we introduce the notion of hyperdiscrete group actions. Every proper action is hyperdiscrete. There are many other interesting examples. It turns out this new notion of group actions mostly fit into the framework for proving FJC developed by A. Bartels, W. Lück and H. Reich. The second is the study of inheritance properties of the conjecture. We study the problem that if a group has a subgroup of finite index satisfying the conjecture, whether the group itself satisfies the conjecture. We reduce the problem to a special case and results obtained for this special case strongly suggests the rationalized conjecture is invariant under commensuration. The third part of this thesis is a joint work with J. Lafont and S. Prassidis. We study the Farrell Nil-groups associated to a virtually cyclic group, which is the obstruction to reduce the family of virtually cyclic groups used in FJC to the family of finite groups. We indeed study the more general Farrell Nil-groups associated to a finite order automorphism of a ring R. We show that any such Farrell Nil-group is either trivial, or infinitely generated (as an abelian group). Building on this first result, we then show that any finite group that occurs in such
Opinion: Recent Developments and Future Directions in Studying the Chemistry of the Mesosphere and Lower Thermosphere

This Opinion article begins with a review of important advances in the science of the Mesosphere and Lower Thermosphere (MLT) region of the atmosphere that have occurred over the past two decades since the founding of Atmospheric Chemistry and Physics . The emphasis is on chemistry (although, of course, this cannot be decoupled from discussion of atmospheric physics and dynamics), and the primary focus is on work during the past 10 years. Topics that are 15 covered include: observations (satellite, rocket and ground-based techniques); the variability and connectedness of the MLT on various length- and time-scales; airglow emissions; the cosmic dust input and meteoric metal layers; and noctilucent (or polar mesospheric) ice clouds. The paper then concludes with a discussion of important unanswered questions and likely future directions for the field over the next decade.
An empirical study on factors influencing job satisfaction of human resource in bank and insurance companies of Nepal

A B S T R A C T Job satisfaction is the positive emotional feeling of an employee towards his/her job. It is one of the most important outcomes of an organization which depends upon the various motivational factors. Out of various motivational theories, this research work has used Herzberg’s Two Factor Theory of motivation to understand the impact of motivational factors on job satisfaction of human resource working in bank and insurance companies of Nepal. Due to the use of the theory, the assumed 15 motivational factors are classified in to two groups-i.e; hygiene factor and motivator factor and later on each of the motivational factors are further grouped in to motivational and de-motivation factors in order to meet the assumption of independent sample t-test through IBM SPSS 25 version. To test internal consistency reliability of questions related to 15 constructs, Cronbach alfa(α) coefficient has been calculated. To create consistency with sample size assumed in Herzberg’s theory of motivation, this research paper has collected primary data from 200 respondents through face-to-face interview method with structured questionnaire. The results of this research work have partially accepted the conclusion of Herzberg’s theory of motivation. Through the result of independent sample t-test, it has been found that, relation with colleague and allowances do not significantly effect on the level of job satisfaction of human resource whereas the remaining 13 motivational factors-i.e.; salary, bonus, vehicle facility, trainings, job promotion, work environment, rules & regulations, loan facility, relation with superior, awards, challenging job, relation with subordinate and job security do significantly effect on job satisfaction of human resource. This research paper concludes that to improve the job satisfaction of human resource, the bank and insurance companies of Nepal should increase their time, effort and finance on the remaining 13 motivational factors rather than on the 2 motivational factors.
IFMSA Policy Proposal Neglected Tropical Diseases

, Human African trypanosomiasis (sleeping sickness disease), dengue and chikungunya, onchocerciasis, rabies, scabies and ectoparasites, leprosy, lymphatic filariasis, food-borne trematodiases, yaws, Trachoma, chromoblastomycosis and other deep mycoses, cysticercosis, soil-transmitted helminths [1]
Daytime Top-of-the-Atmosphere Cirrus Cloud Radiative Forcing Properties at Singapore

AbstractDaytime top-of-the-atmosphere (TOA) cirrus cloud radiative forcing (CRF) is estimated for cirrus clouds observed in ground-based lidar observations at Singapore in 2010 and 2011. Estimates are derived both over land and water to simulate conditions over the broader Maritime Continent archipelago of Southeast Asia. Based on bookend constraints of the lidar extinction-to-backscatter ratio (20 and 30 sr), used to solve extinction and initialize corresponding radiative transfer model simulations, relative daytime TOA CRF is estimated at 2.858–3.370 W m−2 in 2010 (both 20 and 30 sr, respectively) and 3.078–3.329 W m−2 in 2011 and over water between −0.094 and 0.541 W m−2 in 2010 and −0.598 and 0.433 W m−2 in 2011 (both 30 and 20 sr, respectively). After normalizing these estimates for an approximately 80% local satellite-estimated cirrus cloud occurrence rate, they reduce in absolute daytime terms to 2.198–2.592 W m−2 in 2010 and 2.368–2.561 W m−2 in 2011 over land and −0.072–0.416 W m−2 in 2010 and −0.
DESIGN AND OPTIMIZATION OF MICROCRYSTAL PRODUCED BY SONOPRECIPITATION TECHNIQUE: OPTIMIZATION OF PROCESS PARAMETERS

- The aim of the present work was to prepare microparticles by sonoprecipitation method for targeted drug delivery of Beclometasone dipropionate (BDP), an anti-inflammatory corticosteroid available for the treatment of asthma. Experimental designing employed using Design-Expert 5.0 software (StatEase, QD Consulting, Penzance, UK) with linear as design model. The factors investigated were addition rate, stabilizer conc. and sonication time. The addition rate of solvent i.e acetone was studied at 50(-1), 100(0) and 150(1) g /min, stabilizer conc. were 0.5(1), 1(0) and 1.5 %( 1) and sonication time investigated were 1(-1), 2(0) and 3 (1) min. Dry powder were characterized by XRD, DSC, SEM, FTIR, flow property, Particle Size, Particle Distribution and Aerodynamic Particle Size Analysis.It is worth that the particles were uniform in the presence of long time of sonication showed the highest FPF loaded and FPF emitted of 41 (2%) and 84( 4%) respectively, depositing mainly on stages 3 and 4, with much lower amounts collected on the higher stages of the MSLI.
Evaluation of the efficacy of Piper nigrum and Syzygium aromaticum essential oils in association with some antibiotics and the toxicological properties of the combination

The antimicrobial activity of spices of human daily diet has been widely demonstrated. Yet, their capacity of promoting antibiotic activity has not been explored adequately. In this work, the chemical composition of essential oils of Piper nigrum and Syzygium aromaticum from Chad were determined and their antimicrobial effect in combination with different antibiotics towards Staphylococcus aureus,Salmonella enteritidis and Salmonella typhi were assessed . Moreover, the in vivo toxicity of theessential oils alone and in combination with antibiotics was performed. Results indicate that the essential oil of P. nigrum was mostly composed of limonene (18.59%), beta-pinene (11.51%), linalool (10.17%), alpha-pinene (9.96%), while for S. aromaticum essential oil, only three compounds represented about 89% of the identified compounds. They were respectively beta caryophyllene (43.63%), eugenol (42.67%) and alpha-humulene (3.73%). Regarding the antimicrobial properties, Syzygium aromaticum essential oil (EO) used alone was more active than P. nigrum EO with a minimuminhibitory concentration (MIC) of 625 ppm towards all the strains. In combination with selected antibiotics, S. aromaticum gave better results with less indifference association, the best being with gentamicin. This association of the different EOs with gentamicin proved not to be acutely toxic to rats after 14 days of observation at doses ten times the MIC. These results indicated that spices used in human diets can be used for the production of hybrid drugs containing antibiotic and natural substances.
Parameter estimation for the bivariate Lomax distribution based on censored samples

In this paper, we estimate the parameters of the bivariate Lomax distribution of Marshall-Olkin bsed on right censored sample. The advantage of using the EM algorithm is that the observed data vector is viewed as being incomplete but regarded as an observable function of complete data. Then the EM algorithm exploits the reduced complexity of maximum likelihood estimation for complete data. We also derive the standard deviations of the estimates for this bivariate Lomax distribution. A simulation study is conducted to compare the estimated values with the true values.
Advancements in Compiler Design and Optimization Techniques

The modern period has seen advancements in compiler design, optimization technique, and software system efficiency. The influence of the most recent developments in compiler design and optimization techniques on program execution speed, memory utilization, and overall software quality is highlighted in this study. The design of the compiler is advanced by the efficient code that is now structured in research with high-speed performance without manual intervention. The influence of the most recent developments in compiler design and optimization techniques on program execution speed, memory utilization, and overall software quality is highlighted in this paper's thorough analysis.
A portable reflected-sunlight spectrometer for CO2 and CH4

Abstract. Mapping the greenhouse gases (GHGs) carbon dioxide (CO2) and methane (CH4) above source regions such as urban areas can deliver insights into the distribution and dynamics of local emission patterns. Here, we present the prototype development and an initial performance evaluation of a portable spectrometer that allows for measuring CO2 and CH4 concentrations integrated along a long (>10 km) horizontal path component through the atmospheric boundary layer above a target region. To this end, the spectrometer is positioned at an elevated site from which it points downward at reflection targets in the region, collecting the reflected sunlight at shallow viewing angles. The path-integrated CO2 and CH4 concentrations are inferred from the absorption fingerprint in the shortwave–infrared (SWIR) spectral range. While mimicking the concept of the stationary California Laboratory for Atmospheric Remote Sensing – Fourier Transform Spectrometer (CLARS-FTS) in Los Angeles, our portable setup requires minimal infrastructure and is straightforward to duplicate and to operate in various locations. For performance evaluation, we deployed the instrument, termed EM27/SCA, side by side with the CLARS-FTS at the Mt. Wilson Observatory (1670 m a.s.l.) above Los Angeles for a 1-month period in April/May 2022. We determined the relative precision of the retrieved slant column densities (SCDs) for urban reflection targets to be 0.36 %–0.55 % for O2, CO2 and CH4, where O2 is relevant for light path estimation. For the partial vertical column (VCD) below instrument level, which is the quantity carrying emission information, the propagated precision errors amount to 0.75 %–2 % for the three gases depending on the distance to the reflection target and solar zenith angle. The comparison to simultaneous CLARS-FTS measurements shows good consistency, but the observed diurnal patterns highlight the need to take light scattering into account to enable detection of emission patterns.
Ex Vivo Angiogenesis Modeling: A Simple and Cost-Effective Model for Studying Tumor Angiogenesis

Objectives: Endothelial cells (ECs), as the main cell types in the micro- and macro-vascular structure, are crucial to many vital physiological processes occurring in human body among which are both physiologic and pathologic angiogenesis. Due to their great heterogeneity, it is recommended that the ECs of each tissue should be studied separately. Recently, targeting angiogenesis in cancer has become one of the main strategies for cancer management. Accordingly, this study aimed to introduce a simple, cost-effective, and practical model for studying tumor angiogenesis, which can contribute to studies focused on antiangiogenic-based treatments for cancer. Materials and Methods: In this original study, the explants of both normal and tumor tissues of mouse lung and 4T1 mouse cancer model were cultured separately in a collagen type 1 bed. Sprouting ECs formed a network of vessel-liked structures that were photographed as a model for investigating cancerous and normal angiogenesis. These ECs were then isolated from the collagen matrix using collagenase to confirm their endothelial nature. Results: The results showed that the cells invading the collagen matrix and forming a vessel-liked network were of endothelial nature. They were also found to have EC-specific characteristics and express EC-specific markers. These embedded cells may have been treated with the desired drug or further isolated from the collagen matrix and investigated in a genome or protein level. Conclusions: In sum, this modeling had the potential to become a suitable model for studying the pathological angiogenesis such as tumors in human and animal tissues.
The Determinants and Effects of Voluntary Adoption of a Cumulative 1 Voting System: Evidence from China 2

: Using a unique sample of China’s listed firms, we find that firms with strong corporate 8 governance are more likely to adopt the Cumulative Voting System (CVS) and CVS adoption improves 9 firm performance. Further analyses show that the positive relationship between CVS adoption and firm 10 performance is more significant for firms with less mutual funds’ owners hip, in a weak firm information 11 environment, and whose managers have more power. Finally, we find three channels – professionalism 12 of board directors, controlling shareholders’ expropriation , and managerial entrenchment- through which 13 CVS adoption affects firm performance. This study enriches the literature on corporate governance in 14 general and the literature on the principal-principal problems in particular. Our findings also have 15 important policy implications for minority shareholder protection. 16