Miracle-dz/UniFAR-FTUs huggingface dataset:
University of Birmingham UK South Asian patients’ experiences of and satisfaction towards receiving information about biologics in rheumatoid arthritis

Background: Rheumatoid arthritis (RA) causes painful joint inflammation and is incurable, but treatments control RA. Drug regimens are complex, and patients often do not take their medication as expected. Poor medication adherence can lead to poorly controlled disease and worse patient outcomes. Biologics treatments are expensive and require full engagement from patients. We have previously shown that patients from Black ethnic minority backgrounds do not fully engage into treatment plan. This study explored the patients’ experiences in and satisfaction toward receiving information about biologics and future support preferences in South Asian patients with RA. Methods: Twenty South Asian patients with RA from Royal Wolverhampton Hospitals NHS Trust and Central Manchester University Hospitals NHS Foundation Trust participated in individual semistructured interviews. Interviews were transcribed and data were analyzed by using thematic analysis approach. Results: Four overarching themes describe the patients’ experience in and satisfaction toward receiving information on biologics: 1) current provision of information regarding the “biologics journey” and understanding of RA: in this theme, non-English-speaking patients expressed heightened anxiety about stepping up to biologics; 2) experience and perceptions of biologics: many patients were positive about the biologic experience; however, there were patient-perceived delays in getting on to the biologics; 3) factors influencing willingness to try biologics: in this theme, a number of factors were identified including seeking advice from doctors abroad; and 4) recommendations on the desired information to fully understand the use of biologics: some patients valued group discussions, while others suggested receiving RA and biologic information through a video interaction. Conclusion: This novel study provides insight into South Asian RA patients’ experiences in and satisfaction toward receiving information about biologics. South Asian patients with RA reported a range of perceptions about biologics and support preferences, many of which may not be shared with the non-South Asian population.
S. cerevisiae Bio-Ethanol Production as a Sustainable Energy Source

We rely on fossil fuels, which will be outdated in a few decades. Many people are looking for solutions to the current energy dilemma in renewable energy, notably biofuels. Among the various biofuels, bioethanol looks to be the most cost- So Saccharomyces cerevisiae is a well-known bioethanol producer. Yeast cells are stressed and inhibited during fermentation, limiting their efficiency for commercial bioethanol generation. Adopt alternative signal transduction mechanisms to defeat these yeast cells. This analysis focuses on common and underutilised carbon feedstocks that can be easily transformed into bioethanol. The several types of protectants, genes, and processes that may be used to design yeast strains are addressed. As a result, we've proposed techniques for using this profitable option for long-term bioethanol production.
Vacuole membrane fusion: V 0 functions after trans-SNARE pairing and is coupled to the Ca 2 (cid:2) -releasing channel

ore models of membrane fusion postulate that cylinders of integral membrane proteins can initiate a fusion pore after conformational rearrangement of pore subunits. In the fusion of yeast vacuoles, V-ATPase V 0 sectors, which contain a central cylinder of membrane integral proteolipid subunits, associate to form a transcomplex that might resemble an intermediate postulated in some pore models. We tested the role of V 0 sectors in vacuole fusion. V 0 functions in fusion and proton translocation could be experimentally separated via the differential effects of mutations and inhibitory antibodies. Inactivation of the V 0 subunit Vph1p blocked fusion in the terminal reaction P stage that is independent of a proton gradient. (cid:3) vph1 mutants were capable of docking and trans-SNARE pairing and of subsequent release of lumenal Ca 2 (cid:2) , but they did not fuse. The Ca 2 (cid:2) -releasing channel appears to be tightly coupled to V 0 because inactivation of Vph1p by antibodies blocked Ca 2 (cid:2) release. Vph1 deletion on only one fusion partner sufﬁced to severely reduce fusion activity. The functional requirement for Vph1p correlates to V 0 transcomplex formation in that both occur after docking and Ca 2 (cid:2) release. These observations establish V 0 as a crucial factor in vacuole fusion acting downstream of trans-SNARE pairing.
Health Risk Assessment of Heavy Metals via Ingestion and Dermal Absorption of Water in Mogpog and Boac Rivers, Marinduque, Philippines

— The purpose of this paper was to assess the potential human health risk posed by heavy metals in surface water in Marinduque, specifically Boac and Mogpog River. Secondary data from Regional Environmental Management Bureau were used. The health risk assessment was patterned from the model made by the United States Environmental Protection Agency (US EPA) In this study, the pathways of exposure considered were ingestion, and dermal absorption of water pathways. Result revealed that the mean concentrations of the heavy metals in water varied significantly. Among the two exposure pathways for children, dermal absorption provided a higher Hazard Quotient (HQ) for copper, lead and cadmium. On the contrary, for adults only copper and lead have higher HQ of dermal absorption pathway. Hazard indexes (HI) for adult and children via different exposure pathways were found to be less than the standard value of 1. This means that there is less potential to non-carcinogenic health effects and risks. More so, adults were more at risk to cancer via ingestion of water while for dermal absorption exposure pathway children were more at risk.
THE EXISTENCE OF DAY OF THE WEEK EFFECT IN INDIAN STOCK MARKET

The common observation about calendar anomalies is that, after they are documented and analyzed in the academic literature, they often seem to disappear, reverse, or attenuate. The simple explanation behind this behavior is that investors may have exploited the patterns of previous anomalies in trading behaviors which gradually cause an opposite direction or disappearance of documented anomalies. Therefore an attempt has been made to explore the existence of day-of-the effect in Indian stock market for recent 9 years (From 2010 to 2019). The use of daily data makes it possible to examine the relationship between the changes that occur in stock prices from one trading day to the next and over weekends or, in other words, to study the weekend effect. In particular, it is possible to test whether the rapidity of the process whereby stock prices are formed changes when the market is closed, i.e. whether the process is defined in terms of market time or real time .
Assessment of factors affecting flicker ERGs recorded with RETeval from data obtained from health checkup screening

Purpose To determine the factors significantly associated with the amplitudes and implicit times of the flicker electroretinograms (ERGs) recorded with the RETeval system by analyzing the comprehensive data obtained during a health checkup screening. Methods Flicker ERGs were recorded with the RETeval system from 373 individuals who had a normal fundus and optical coherence tomography images. The sex, age, anthropometric, ophthalmologic, and hematologic data were collected from all participants who were 40- to 89-years-of-age. Univariable and multivariable linear mixed effects regression analyses were performed to identify factors that were significantly associated with the implicit times and amplitudes of the RETeval flicker ERGs. Results Univariable linear mixed effects regression analysis showed significant correlations between the implicit times and the best-corrected visual acuity, the age, the axial length, the blood sugar level, and the blood urea nitrogen level. Analyses by multivariable linear mixed effects regression identified that the axial length (β = 0.28), the age (β = 0.24), and the blood sugar level (β = 0.092) were three independent factors that were significantly correlated with the implicit times of the RETeval flicker ERGs. Univariable linear mixed effects regression analysis also showed significant correlations between the amplitudes of the RETeval flicker ERGs and the age, the platelet count, and the creatinine level. Multivariable linear mixed effects regression models identified the age (β = -0.092), the platelet count (β = 0.099), and the creatinine level (β = -0.12) as three independent factors that were significantly correlated with the amplitudes of the RETeval flicker ERGs. However, the smoking habits, body mass index, and the blood pressure were not significantly correlated with either the implicit times or amplitudes of the RETeval flicker ERGs. Conclusions Our results indicate that the age and some ophthalmologic and hematologic findings but not the anthropometric findings were significantly associated with the implicit times and amplitudes of the RETeval flicker ERGs. Thus, clinicians should remember these factors when analyzing the RETeval flicker ERGs.
A Tilt Sensor Node Embedding a Data-Fusion Algorithm for Vibration-Based SHM

This work describes a miniaturized sensor network based on low-power, light-weight and small footprint microelectromechanical (MEMS) sensor nodes capable to simultaneously measure tri-axial accelerations and tri-axial angular velocities. A real-time data fusion algorithm based on complementary filters is applied to extract tilt angles. The resulting device is designed to show competitive performance over the whole frequency range of the inertial units. Besides the capability to provide accurate measurements both in static and dynamic conditions, an optimization process has been designed to efficiently make the fusion procedure running on-sensor. An experimental campaign conducted on a pinned-pinned steel beam equipped with a network comprising several sensor nodes was used to evaluate the reliability of the developed architecture. Performance metrics revealed a satisfactory agreement to the physical model, thus making the network suitable for real-time tilt monitoring scenarios.
Exploring Factors Influencing the Teaching of Culture and Its Challenges: Teachers’ Perceptions

This study, as part of a more comprehensive master’s thesis, investigated the perceptions of Thai teachers of English about culture teaching. The aims of the study were twofold: (a) to identify the key factors influencing the teaching of culture in the English language classroom; and (b) to identify the key difficulties and problems in the teaching of culture in the English language classroom. A survey questionnaire was employed to collect the intended data. A total of 556 questionnaires were distributed to the teachers from 26 public universities in 6 geographical regions of Thailand. Eighty-four questionnaires were returned; however, only 65 were qualified for the analysis. The obtained data was analyzed by using SPSS. The descriptive statistics, namely, frequencies and percentages were used to discuss the teachers’ views on the aforementioned aspects. Despite the low return rate, the results indicated that three factors regarding teacher’s knowledge of the foreign culture, course description, and learners’ interest were believed to be significant in influencing the teaching of culture. Also, the teachers in the study pointed to teacher’s limited knowledge of the foreign culture, and learners’ lack of interest in learning the foreign culture as two significant difficulties and problems detrimental to the teaching of culture. Although the results of the study help shed some light on culture teaching in the Thai ELT context, further research is encouraged to either substantiate or challenge the findings obtained from this study.
Biceps femoris architecture and strength in athletes with a prior ACL reconstruction

23 Purpose: To determine if limbs with a history of anterior cruciate ligament (ACL) injury 24 reconstructed from the semitendinosus (ST) display different biceps femoris long head (BF lh ) 25 architecture and eccentric strength, assessed during the Nordic hamstring exercise, compared 26 to the contralateral uninjured limb. Methods: The architectural characteristics of the BF lh 27 were assessed at rest and at 25% of a maximal voluntary isometric contraction (MVIC) in the 28 control (n=52) and previous ACL injury group (n=15) using two-dimensional 29 ultrasonography. Eccentric knee-flexor strength was assessed during the Nordic hamstring 30 exercise. Results: Fascicle length was shorter (p=0.001; d range: 0.90 to 1.31) and pennation 31 angle (p range: 0.001 to 0.006: d range: 0.87 to 0.93) was greater in the BF lh of the ACL 32 injured limb when compared to the contralateral uninjured limb at rest and during 25% of 33 MVIC. Eccentric strength was significantly lower in the ACL injured limb than the 34 contralateral uninjured limb (-13.7%; -42.9N; 95% CI = -78.7 to -7.2; p=0.021; d =0.51). 35 Fascicle length, MVIC and eccentric strength were not different between the left and right 36 limb in the control group. Conclusions: Limbs with a history of ACL injury reconstructed 37 from the ST have shorter fascicles and greater pennation angles in the BF lh compared to the 38 contralateral uninjured side. Eccentric strength during the Nordic hamstring exercise of the 39 ACL injured limb is significantly lower than the contralateral side. These findings have 40 implications for ACL rehabilitation and hamstring injury prevention practices which should 41 consider altered architectural characteristics.
Enhancing cognitive and entrepreneurship competencies through EBL Preparation for disruption era

Purpose – Entrepreneurship-based learning (EBL) is one of the student-center learningmethods that can answer learning challenges in the era of industrial revolution 4.0. EBL is expected to improve students ’ competencies and make students more adaptable to the changes in the world of work in the future. The paper aims to discuss this issue. Design/methodology/approach – This study uses quasi-experiments and divides classes into project class and control class. The project consists of making business proposals, conducting business, liquidating the partnership, and recording business transaction using the Xero platform. The Wilcoxon Signed Ranks Test, Mann – Whitney Test and independent t -test were carried out to test whether there are differences of cognitive abilities and entrepreneurial (general, social and functional) competencies between the project class and control class. Findings – The results of the study shows there are differences of understanding of partnership accounting and the achievement of social and functional entrepreneurial competencies between the project class and control class. Research limitations/implications – This study implies in using EBL to improve entrepreneurial skills for students beyond cognitive abilities. Originality/value – The novelty of this research is the implementation of EBL in partnership accounting topics.
Exploring passengers' attitudes and loyalty in jabodetabek paratransit during Covid-19 pandemic

Paratransit is public transportation without a fixed route and schedule Taxi bikes, taxis, and pedicabs are kinds of paratransit Online paratransit reflects public's lenience and choice of non-mass transportations The covid-19 pandemic has limited the paratransit choices that increase contact with other people This paper aims to explore the factors influencing the paratransit passengers' loyalty in Jabodetabek Four factors are proposed, namely affection, cognition, frequency, and subjective norm This research employs a linear regression in 107 paratransit users The results reveal that the affective factor influences loyalty On the other hand, cognition is weakly significant Subjective norm and frequency do not significantly influence the paratransit passengers' loyalty
Current Progress in Cross-Platform Application Development Evaluation of Frameworks for Mobile Application Development

— Cross-platform development is increasingly driven by web frameworks. Modern frameworks typically support application deployment for different platforms as well as the creation of progressive web apps. This approach is also driven by the increasing number of different device types and platforms. Development efforts can be significantly reduced by utilization of modern frameworks. Hence, several modern frameworks that have proven to be suitable for cross-platform development will be compared in this article. This article will extend our previous research on cross-platform development by several dimensions: at first, research on literature and technology developments regarding cross-platform development is extended. Secondly, we added further frameworks into our analysis. Thirdly, the evaluation approach is systematically extended to discuss each framework on an individual basis. This is driven by a reference architecture and implementation. To create a sound and objective framework comparison, the reference architecture is utilized to implement applications by means of each framework. Subse-quently tests for different mobile devices and platforms are defined. All frameworks are compared according several key metrics. Finally, we describe current strengths and weaknesses of all approaches before giving an outlook on future steps of research.
A theoretical review of conceptual model for E-CRM success in telecommunication companies

Electronic customer relationship management (E-CRM) is a modern tool to secure and maintain competitive advantage that focuses on customers. Telecommunication companies nowadays are attentive to the employees, in their effort to enhance job satisfaction through the development of E-CRM. This study aims to integrate theories for a development model to enhance employee satisfaction in telecommunication companies that employed the method of summarizing theoretical reviews. This study contributed to the knowledge in the domain of E-CRM and the success factors in organizations. Therefore, it is important to improve a readily available model that combines every theory that correlated with the current study. The adopted model in telecommunication companies ensures the successful adoption of E-CRM that affects employee satisfaction and enhances individual performance. Additionally, this study contributed to the improvement of an integrated model that combines technology, organization, and individual factors influencing telecommunication companies in developing countries.
Prevalence And Socio - Demographic Determinants Of Sexual Dysfunction Among Married Women Of Reproductive Age Group In South West Nigeria

TO (2020) Prevalence and Socio - Demographic Determinants of Sexual Dysfunction among Married Women of Reproductive Age Group in South West Nige- ria. 5: 046. Abstract Background information: Healthy sexual functioning is an import- ant contributor to women’s sense of well-being and quality of life. Sexual Dysfunction (SD) refers to a problem during any phase of the sexual response cycle that prevents the individual from experiencing satisfaction from the sexual activity. It affects the self-esteem, quality of life and has threatened homes, therefore imperative to study this aspect of human life so as to improve the stability of families in our society. Aim: To determine the prevalence and determinant of sexual dys- function among married women in Osogbo metropolis. Method: This is a descriptive cross sectional study in which 500 interviewer administered pre-tested, semi-structured questionnaires were analysed using SPSS statistical software version 23. Results: Majority of respondents 306 (61.2%) were within the ages of 30-44 with the mean age of 34.8+2 years. Majority of respondents 63% were married. Of all the 500 respondents, 338(67.6%) have heard about sexual dysfunction before the study, The prevalence of one form of sexual dysfunction among the respondents was 444 (89%), and was found to be associated with fear, sadness and guilt in 6.4%, 8.8% and 17% of respondents respectively. Majority of the respondents 316 (63.2%) were desirous of change in their love life due to sexual dysfunction. Monogamous family setting, professionals and women within the ages of 30-44 years were significantly more likely have sexual dysfunction. However, there was no significant association between, a low family income, being overweight or obese, being diabetic or hypertensive with sexual dysfunction. Conclusion: This study shows high prevalence of one form or the other of sexual dysfunction among the respondents. It is therefore recommended that awareness about sexual dysfunctions through health education interventions should be scaled among women of reproductive age in Nigeria.
Quantifying information and uncertainty of rock property estimation from seismic data

Geophysical prospecting consists of making a quantitative inference about subsurface properties from geophysical measurements. Due to many ineluctable difficulties, observed data are almost always insufficient to uniquely specify the rock properties of interest. Hence, inevitable uncertainty remains after the estimation. The sources of the uncertainty arise from many factors: inconsistency in data acquisition conditions, insufficient available data as compared to the subsurface complexities, limited resolution, imperfect dependence between observed data and target rock properties, and our limited physical knowledge. While the uncertainty has been identified for a long time, quantitative framework to discuss the uncertainty has not been well established. The objective of this dissertation is to quantify uncertainty of rock property estimation and to reduce it by using multiple seismic observables. Using existing laboratory data and rock physics model parameters, we establish the general relationships between rock properties and pairs of seismic attributes. We show how optimal selections of seismic attributes allow us to better distinguish different rock property effects. One of the novel innovations in this work is to combine statistical formulations—information theory and Bayes decision theory—with rock physics models to quantitatively describe the dependence of seismic attributes on several important rock properties. Various sources of uncertainty about rock property estimation are quantified using the developed formulations. Furthermore, We propose a method of combining stochastic simulations and Bayes inversion to quantify the uncertainty about the dependence between seismic observables and target rock properties, caused by ignorance of other rock properties. We apply this method to explore scale effects
Brown adipose tissue and seasonal variation in people

This is an uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association, publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online at http://diabetes.diabetesjournals. org. Diabetes Publish Ahead of Print, published online August 20, 2009