Miracle-dz/UniFAR-FTUs huggingface dataset:
Associations Between Physical Activity and Hypertension in Chinese Children: A Cross-Sectional Study From Chongqing

Background: Childhood blood pressure is a marker for cardiovascular disease risk later in life. Few studies examined the association between physical activity (PA) and hypertension in Chinese children, and this study aimed to explore this relationship. Methods: A cross-sectional study among pupils was conducted in Chongqing in 2014. In total, 15,203 children aged 6–12 years in Chongqing were included in this study. The duration of self-reported PA on school days and the weekend in pupils were collected with a standardized questionnaire. Results: The results showed that, on school days, only 22.3% of boys and 17.8% of girls engaged in more than 60 min of PA per day; while on the weekend, only 38.5% of boys and 32.0% of girls engaged in at least 60 min of PA per day. There was no strong evidence for an association between PA and systolic or diastolic hypertension in boys. However, in girls, a weak negative association between PA on weekdays and hypertension was observed, and there was a significant interactive effect of PA and obesity on hypertension risk (P for interaction = 0.042). In obese children, PA was positively related to the risk of hypertension. Conclusion: The overall level of PA among pupils in Chongqing was insufficient, and a weak negative relationship between PA and hypertension was found in girls.
The Effects of Climatic Variability on the Feeding Ecology of the Scalloped Hammerhead Shark (Sphyrna lewini) in the Tropical Eastern Pacific

Climatic variability changes ocean productivity and generates systematic cascading effects in marine food webs. Studying the feeding ecology of top predators, such as sharks, can provide insights into the overall health of marine ecosystems. We conducted a 4-year study to evaluate seasonal and inter-annual trophic variations and their relationship with El Niño Southern Oscillation (ENSO) on the largest aggregation of scalloped hammerhead shark (Sphyrna lewini) in the Tropical Eastern Pacific (TEP). We used δ13C and δ15N signatures to gain a better understanding of hammerheads’ feeding strategies as well as variations of their isotopic niche. Our results suggest that the hammerhead sharks in the Galapagos Marine Reserve respond to climatic fluctuations, with La Niña event potentially benefiting their trophic needs as the overall marine productivity increased in the region. This work is the first of its kind in the TEP and provides insights on how climate variability influences the feeding ecology of this critically endangered species. It also highlights the need to incorporate climate-related conservation strategies into the management of this species since ENSO events become more frequent and intense in the face of climate change.
Avens Root (Geum Urbanum L.) Extract Discovered by Target-Based Screening Exhibits Antidiabetic Activity in the Hen’s Egg Test Model and Drosophila melanogaster

Medicinal plant extracts are becoming increasingly important as an alternative for traditional drugs against diabetes mellitus (DM). For this reason, we initialized a target-based screening of 111 root extracts from an open access plant extract library (PECKISH) by ascertaining their in-vitro inhibitory efficacy on α-glucosidase. The two most active extracts Geum urbanum L. (roseroot) and Rhodiola rosea L. (avens root) were further tested for their antidiabetic activities in terms of their impact on different regulatory key points of glucose homeostasis. To this end, various enzyme- and cell culture-based in-vitro assays were employed including the determination of sodium-dependent glucose transporter 1 (SGLT1) activity in Caco-2 monolayers by Ussing chambers and of glucose transporter 4 (GLUT4) translocation in a GFP-reporter cell line. Subsequently, the antidiabetic potential of the root extracts were further evaluated in in-vivo models, namely hen’s eggs test and the fruit fly Drosophila melanogaster. Avens root extract was found to be a more potent inhibitor of the enzymes α-glucosidase and dipeptidyl peptidase-4 (DPP4) than roseroot extract. Most importantly, only avens root extract exhibited antidiabetic activity in the two in-vivo models eliciting a reduced blood glucose level in the in-ovo model and a decline of the triglyceride level in a dietary starch-induced D. melanogaster obesity model. Analyses of the polyphenolic composition of the avens root extract by HPLC revealed a high content of ellagic acid and its derivatives as well as ellagitannins such as pedunculagin, stenophyllanin, stachyurin, casuarinin and gemin A. In conclusion, avens root extract represents a promising medicinal plant that should be considered in further in-vivo studies on hyperglycemia in laboratory rodents and humans.
A Support Vector Machine Based on Liquid Immune Profiling Predicts Major Pathological Response to Chemotherapy Plus Anti-PD-1/PD-L1 as a Neoadjuvant Treatment for Patients With Resectable Non-Small Cell Lung Cancer

The biomarkers for the pathological response of neoadjuvant chemotherapy plus anti-programmed cell death protein-1/programmed cell death-ligand 1 (PD-1/PD-L1) (CAPD) are unclear in non-small cell lung cancer (NSCLC). Two hundred and eleven patients with stage Ib-IIIa NSCLC undergoing CAPD prior to surgical resection were enrolled, and 11 immune cell subsets in peripheral blood were prospectively analyzed using multicolor flow cytometry. Immune cell subtypes were selected by recursive feature elimination and least absolute shrinkage and selection operator methods. The support vector machine (SVM) was used to build a model. Multivariate analysis for major pathological response (MPR) was also performed. Finally, five immune cell subtypes were identified and an SVM based on liquid immune profiling (LIP-SVM) was developed. The LIP-SVM model achieved high accuracies in discovery and validation sets (AUC = 0.886, 95% CI: 0.823–0.949, P < 0.001; AUC = 0.874, 95% CI: 0.791–0.958, P < 0.001, respectively). Multivariate analysis revealed that age, radiological response, and LIP-SVM were independent factors for MPR in the two sets (each P < 0.05). The integration of LIP-SVM, clinical factors, and radiological response showed significantly high accuracies for predicting MPR in discovery and validation sets (AUC = 0.951, 95% CI: 0.916–0.986, P < 0.001; AUC = 0.943, 95% CI: 0.912–0.993, P < 0.001, respectively). Based on immune cell profiling of peripheral blood, our study developed a predictive model for the MPR of patients with NSCLC undergoing CAPD treatment that can potentially guide clinical therapy.
The Twists and Turns of Diagnosis and Treatment of Pediatric Neuro-Behcet's Disease: A Case Report and Literature Review

Background: The neurological manifestation of Behcet's disease (BD) is known as Neuro-Behcet's disease (NBD). The lack of a specific diagnostic method for NBD renders the diagnosis and treatment of NBD challenging. Methods and Results: We report a boy aged 11 years and 11 months who underwent right-eye intraocular lens implantation, appendectomy, perianal abscess removal, thalidomide therapy, and infliximab infusions for his Crohn disease. Magnetic resonance venography (MRV) and magnetic resonance imaging (MRI) were performed to address the onset of headache during the course of his treatment, and cerebral venous sinus thrombosis was detected. After the diagnosis of NBD, the patient was treated with anticoagulation therapy (nadroparin calcium), low-dose corticosteroids, and an immunosuppressant (cyclophosphamide), and consequently, he recovered. Conclusion: This case report shows that NBD is prone to misdiagnosis and missed diagnosis and should be diagnosed based on clinical manifestations and results from colonoscopy, pathological examination, and MRI or MRV.
Insights Into the Inhibition of MOX-1 β-Lactamase by S02030, a Boronic Acid Transition State Inhibitor

The rise of multidrug resistant (MDR) Gram-negative bacteria has accelerated the development of novel inhibitors of class A and C β-lactamases. Presently, the search for novel compounds with new mechanisms of action is a clinical and scientific priority. To this end, we determined the 2.13-Å resolution crystal structure of S02030, a boronic acid transition state inhibitor (BATSI), bound to MOX-1 β-lactamase, a plasmid-borne, expanded-spectrum AmpC β-lactamase (ESAC) and compared this to the previously reported aztreonam (ATM)-bound MOX-1 structure. Superposition of these two complexes shows that S02030 binds in the active-site cavity more deeply than ATM. In contrast, the SO3 interactions and the positional change of the β-strand amino acids from Lys315 to Asn320 were more prominent in the ATM-bound structure. MICs were performed using a fixed concentration of S02030 (4 μg/ml) as a proof of principle. Microbiological evaluation against a laboratory strain of Escherichia coli expressing MOX-1 revealed that MICs against ceftazidime are reduced from 2.0 to 0.12 μg/ml when S02030 is added at a concentration of 4 μg/ml. The IC50 and Ki of S02030 vs. MOX-1 were 1.25 ± 0.34 and 0.56 ± 0.03 μM, respectively. Monobactams such as ATM can serve as informative templates for design of mechanism-based inhibitors such as S02030 against ESAC β-lactamases.
Parallel-connected five-level PWM inverters

Multilevel PWM inverters have significant advantages over the conventional one because of the capability of operating the motor with nearly sinusoidal current waveforms and higher output voltages. In order to increase the power rating of the inverter, connection in parallel would be effective in the present case. In high-power applications, for instance, the carriers should be synchronized to the modulating sinusoidal waves. Moreover, for the interphase reactor, lower order harmonic application is prohibited. In practice, to improve the harmonic characteristics of the parallel-connected five-level inverter, two modulation strategies have been devised and designed in this paper. It is found that the DC current flow through the DC power supplies can be controlled by means of phase shifting of the injected third order harmonics. In the case of a static VAr compensator (SVC), the output capacitor voltages can be controlled by means of this technique.
Intracellular Recording of Cardiomyocytes by Integrated Electrical Signal Recording and Electrical Pulse Regulating System

The electrophysiological signal can reflect the basic activity of cardiomyocytes, which is often used to study the working mechanism of heart. Intracellular recording is a powerful technique for studying transmembrane potential, proving a favorable strategy for electrophysiological research. To obtain high-quality and high-throughput intracellular electrical signals, an integrated electrical signal recording and electrical pulse regulating system based on nanopatterned microelectrode array (NPMEA) is developed in this work. Due to the large impedance of the electrode, a high-input impedance preamplifier is required. The high-frequency noise of the circuit and the baseline drift of the sensor are suppressed by a band-pass filter. After amplifying the signal, the data acquisition card (DAQ) is used to collect the signal. Meanwhile, the DAQ is utilized to generate pulses, achieving the electroporation of cells by NPMEA. Each channel uses a voltage follower to improve the pulse driving ability and isolates each electrode. The corresponding recording control software based on LabVIEW is developed to control the DAQ to collect, display and record electrical signals, and generate pulses. This integrated system can achieve high-throughput detection of intracellular electrical signals and provide a reliable recording tool for cell electro-physiological investigation.
Dam monitoring with fiber optics deformation sensors

The monitoring of dams represents an important task in the management of hydroelectric systems. Their economic, social and environmental value imposes to know well the real behavior of the structure and its foundations. This paper shows in two practical cases the possibility to improve the quality of deformation measurements by an appropriate fiber optics sensor network. The first case is a study showing the technical and economical feasibility to install an extended, spatial fiber optics deformation sensor network to detect the relative deflection of an entire shell dam. At this purpose of theoretical study has been evaluated on the base of typical load situations with their effective deflections on the Schiffenen dam, a shell-shaped concrete structure near Fribourg. The second case concerns the development and realization of two long fiber optics deformation sensors anchored in the rock to monitor the displacement of the dam relatively to its underground. These sensors have been installed in the Emosson shell dam.
Early Intervention in Severe Autism: Positive Outcome Using Exchange and Development Therapy

Early intervention programs positively affect key behaviors for children with autism spectrum disorder (ASD). However, most of these programs do not target children with severe autistic symptomatology associated with intellectual disability (ID). This study aimed to investigate the psychological and clinical outcomes of children with severe autism and ID enrolled in the Tailored and Inclusive Program for Autism—Tours (TIPA-T). The first step of the TIPA-T is the Exchange and Development Therapy (EDT): an individual neurofunctional intervention consisting of one-to-one exchanges between a child and a therapist taking place in a pared-down environment. It aims to rehabilitate psychophysiological abilities at the roots of social communication through structured sequences of “social play. ” Cognitive and socio-emotional skills and general development were evaluated with the Social Cognitive Evaluation Battery scale and the Brunet–Lézine Scale—Revised, respectively, before and after 9 months of intervention in 32 children with ASD and ID. Autistic symptomatology was evaluated with the Behavior Summarized Evaluation—Revised scale at five time-points in a subset of 14 children, both in individual and group settings. Statistically significant post-intervention improvements were found in cognitive and socio-emotional skills. All but one child showed improvements in at least one social domain, and 78% of children gained one level in at least four social domains. Twenty-nine children improved in cognitive domains, with 66% of children improving in at least three cognitive domains. Autistic symptomatology evaluated in one-to-one settings significantly decreased with therapy; this reduction was observed in more than 85% of children. In group settings, autistic symptomatology also decreased in more than 60% of children. Global developmental age significantly increased by 3.8 months. The TIPA-T, including EDT in particular, improves socio-emotional skills of most children with ASD and reduces autistic symptomatology, yet with heterogeneous outcomes profiles, in line with the strong heterogeneity of profiles observed in ASD. At the group level, this study highlights the benefits of the TIPA-T for children with severe autism and associated ID. Assessment of autistic core symptoms showed an improvement of social interaction, both in one-to-one and group evaluations, demonstrating the generalizability of the skills learned during the EDT.
Feedback linearisation oriented approach to Q-V control of grid connected photovoltaic units

This study proposes a new control scheme to manage active and reactive power injections into the distribution grids provided by photovoltaic (PV) generating units. Such scheme is derived by resorting to the so-called ‘feedback linearisation’ theory, which relies on the central concept to algebraically transform non-linear systems dynamics into fully or partly linear ones, so that linear control techniques can be applied. To do this, a suitable state transformation is required, in order to simplify the form of the power system to be controlled. The developed scheme receives as input the reference signal for the PV unit voltage (generated by a maximum power point tracker controller) and the one for the desired reactive power and produces as output the modulating signal of the grid interface pulse width modulation inverter. A detailed simulation campaign on a medium voltage grid connected PV power plant is performed in the PSCAD-EMTDC electromagnetic environment, in order to verify the effectiveness of the proposed control algorithm and to highlight its main advantages with respect to traditional regulation methodologies.
Filtering Performance of Digital Alternate Array on Target Tracking

For target tracking of agile digital array, we propose a novel model called alternate array. The model means that total array is divided into vertical subarray at the present moment, and vertical subarray is transformed into horizontal subarray at the next moment, then the subarray comes to the first subarray divisions, and so on. Alternate array gives rise to differences of statistical characters of measurement error. Filtering performance is influenced by the feature of measurement data. In the paper, we come up with a new method based on Kalman filter (KF) to solve the difficulty. The new method merges pre-processing and data fusion thought together. Simulation results demonstrate the validity of the proposed algorithm.
Genomic and Transcriptomic Analysis Provide Insights Into Root Rot Resistance in Panax notoginseng

Panax notoginseng (Panax notoginseng (Burk.) F.H. Chen), a plant of high medicinal value, is severely affected by root rot during cultivation. Here, we generated a reference genome of P. notoginseng, with a contig N50 size of 241.268 kb, and identified 66 disease-resistance genes (R-genes) as candidate genes for breeding disease-resistant varieties. We then investigated the molecular mechanism underlying the responses of resistant and susceptible P. notoginseng genotypes to Fusarium oxysporum infection at six time points by RNA-seq. Functional analysis of the genes differentially expressed between the two genotypes indicated that genes involved in the defense response biological process like hormone transduction and plant-pathogen interaction are continuously and highly expressed in resistant genotype during infection. Moreover, salicylic acid and jasmonic acid levels gradually increased during infection in the resistant genotype. Coexpression analysis showed that PnWRKY22 acts as a hub gene in the defense response of the resistant genotype. Finally, transiently overexpressing PnWRKY22 increased salicylic acid levels in P. notoginseng leaves. Our findings provide a theoretical basis for studying root rot resistance in P. notoginseng.
A Breakdown of the Psychomotor Components of Input Device Usage

Summary: This study investigates the breakdown of the psychomotor components of three different input devices, the mouse, trackball, and RollerMouse TM using the Stochastic Optimized Submovement Model. Primary movement time (PMT), Total Movement Time (TMT), Primary Movement Distance (PMD), and Total Movement Distance (TMD) were examined for each device. Results showed that psychomotor variables related to the primary phase of movement help to pinpoint how performance efficiency is affected by a particular device. For example, the relationship between % PMD and efficiency suggests that a device that affords users an initial accurate movement decreases the need for more or longer corrective submovements, thus reducing movement time.
Two-Stage Energy Management for Energy Storage System by Using Stochastic Model Predictive Control Approach

There is a growing tendency for industrial consumers to invest in both photovoltaic (PV) and energy storage systems (ESSs) to meet their electricity requirements. However, the uncertainty of load demand and PV output brings great challenges for ESS operation. In this paper, a stochastic model predictive control (MPC) approach-based energy management strategy for ESSs is proposed. A non-parametric probabilistic prediction method embedded in time series correlation is adopted to describe the uncertainty of load demand and PV output. Then, a two-stage energy management model is proposed aiming at minimizing the total operation cost. The upper stage can generate an hourly operation strategy for ESSs, while the lower stage focuses on a more detailed minute-level operation strategy. The hourly operation strategy is also used as a basis to guide the ESS operation in the lower stage. Besides, a chance constraint was introduced to achieve a win–win solution between PV power consumption and electricity tariff, while the terminal value constraint of the capacity of ESSs to better cope with the uncertainty beyond the prediction time window. Finally, the numerical results showed that the proposed method can achieve an effective ESS energy management strategy.
Antcin K Inhibits TNF-α, IL-1β and IL-8 Expression in Synovial Fibroblasts and Ameliorates Cartilage Degradation: Implications for the Treatment of Rheumatoid Arthritis

Extracts from Taiwan’s traditional medicinal mushroom, Antrodia cinnamomea, exhibit anti-inflammatory activities in cellular and preclinical studies. However, this paper is the first to report that Antcin K, a triterpenoid isolated from A. cinnamomea, inhibits proinflammatory cytokine production in human rheumatoid synovial fibroblasts (RASFs), which are major players in rheumatoid arthritis (RA) disease. In our analysis of the mechanism of action, Antcin K inhibited the expression of three cytokines (tumor necrosis factor alpha [TNF-α], interleukin 1 beta [IL-1β] and IL-8) in human RASFs; cytokines that are crucial to RA synovial inflammation. Notably, incubation of RASFs with Antcin K reduced the phosphorylation of the focal adhesion kinase (FAK), phosphoinositide 3-kinase (PI3K), protein kinase B (AKT) and nuclear factor-κB (NF-κB) signaling cascades, all of which promote cytokine production in RA. Intraperitoneal injections of Antcin K (10 mg/kg or 30 mg/kg) attenuated paw swelling, cartilage degradation and bone erosion, and decreased serum levels of TNF-α, IL-1β, IL-8 in collagen-induced arthritis (CIA) mice; in further experiments, IL-6 levels were similarly reduced. The inhibitory effects of Antcin K upon TNF-α, IL-1β and IL-8 expression in human RASFs was achieved through the downregulation of the FAK, PI3K, AKT and NF-κB signaling cascades. Our data support clinical investigations using Antcin K in RA disease.
Universitµa degli Studi di Parma

-induced phase transition in DmTTF-CA 132.1 Aim of the work . 132.2 Experimental . 152.3 Valence instability . 152.4 Dimerization instability . 182.5 Soft-mode and dielectric properties . 212.6 Discussion and conclusions . 273 Electric ﬂeld eﬁect on TTF-CA phases 303.1 Aim of the work . 303.2 Experimental . 313.3 Results . 313.4 Discussion and perspectives . 39
Effect of Asymmetrical Edge Disconnection on Equivalent Series Resistance of Metalized Polypropylene Capacitors

In order to investigate the effect of asymmetrical partial edge disconnection on the Equivalent Series Resistance (ESR) of Metalized polypropylene capacitors an experimental study has been made. Theoretical analysis made using PSPICE simulation package reveals that electrode resistance of individual turn rises from 10 to 30% depending on the location of the turn. This rise is not measureable at all the frequencies as ESR is frequency dependent and it includes resistance due to electrodes and dielectric losses. Metalized polypropylene capacitors were made with partial edge disconnection at one end (asymmetrical) with different magnitudes of edge disconnection by masking during the process of zinc spraying. Measurements of ESR have been made in a wide range of frequencies from 20 Hz to 50 MHz and the theoretical results are validated through the experimental data. A short time step stress test was conducted on the capacitors, which can be further developed as a type test to identify the capacitors with partial edge disconnection.