Miracle-dz/UniFAR-FTUs huggingface dataset:
A Mass Spectrometric Approach to the Proteomic Profiling of the Canis lupus familiaris Acquired Enamel Pellicle on Hydroxyapatite Discs

The acquired enamel pellicle (AEP) is a multi-protein film attached to the surface of teeth, which functions to lubricate the dental surface, form an anti-erosive barrier and exhibits antimicrobial properties. The initiation of AEP formation occurs within seconds of exposure to saliva, a biofluid rich in protein species. While there have been many publications on the formation of human AEP there is little research on the composition of canine AEP during its acquisition. The aim of these studies was to explore the composition of canine AEP formation, utilising hydroxyapatite (HA) discs as a tooth substitute matrix, over time. Qualitative and quantitative proteomics techniques using tandem mass tag labelled peptides and LC-MS/MS were used to follow the formation of canine AEP on hydroxyapatite discs over the course of an hour. Proteins adsorbed to the HA surface included highly abundant proteins in canine saliva, antimicrobial proteins, protease inhibitors and the buffering agent carbonic anhydrase. Greater understanding of the canine AEP deepens fundamental knowledge of the early processes driving bacterial colonisation of the tooth surface and subsequent plaque accumulation.
Economic and traffic impacts following the installation of new bicycle facilities: A Denver case study

America is currently experiencing a unique departure from the historical vehicle miles traveled (VMT) trend, often referred to as "peak travel. " Decreasing VMT numbers suggest that the US is currently experiencing an unprecedented change in the way individuals utilize transportation systems. The following research calls on a need to understand the importance of improving alternative transportation infrastructure, namely cycling facilities, and how this impacts local businesses and their communities. This research informs the overarching question, "What are the economic and traffic impacts of cycling facilities? " A mixed methods analysis of retail sales tax, traffic count, and RTD transit access data helped to uncover the economic and traffic impacts following the installation of improved cycling facilities in Denver, CO. In an effort to inform future transportation projects, the findings suggest how the street improvements influenced the local sales tax character of the corridor and what impact they had on bicycle traffic. This research highlights the positive economic impacts and increased levels of bicycle traffic following the installation of new bicycle facilities. There are four broad conclusions within this research. First, Denver exhibits untapped potential for increasing the bicycle mode share, especially when bike trips are combined with transit trips. Second, bicycle facilities are correlated with statistically significant positive economic impacts for local businesses and do not have negative impacts.
Hybridization of zero forcing-minimum mean square error equalizer in multiple input multiple output system

Transmission of high data rate over multipath environment is associated with many wireless applications. However, this transmission results in high delay which leads to ISI distortion and causes high error. The existing LE in MIMO systems such as ZF equalizer used in addressing this problem reduces the ISI distortion completely but results in noise amplification. Likewise, MMSE equalizer only reduces the noise but cannot eliminate ISI. Therefore, this paper proposed a hybrid LE for Wi-Fi over Weibull fading channel. The hybridized ZF-MMSE equalizer was developed using conventional ZF and MMSE equalizers. Digital transmitted signal propagated over Weibull fading channel is received at the receiver through multiple antennas and then combined using MRC. The combined signal is then equalized using hybrid ZF-MMSE to eliminate both the ISI and the amplified noise. The developed model was simulated in MATLAB software environment and evaluation was performed using BER and Pout. The results obtained revealed that the hybrid ZF-MMSE equalizer gave better performance over existing equalizers in a MIMO system. Therefore, the proposed equalizer will help improve the performance of the Wi-Fi technology.
Le projet de liaison Rhin-Rhône à gabarit européen ou les mystères d'un pari

From the early sixties, the Rhine-Rhone Canal project gave rise to numerous announcements according to which the project was to be carried out shortly, but gave also rise to a lot of forecasts and assessment studies which suggested to decision makers not to realize it. Even though waterborne transport is generally regarded as little promising especially for sites where the network is allowing too many locks, the realization of the project was enacted in 1995 in a French Act. According to this Act, the project is to reach completion by 2010. Nevertheless, in 1961, French Commissaire au Plan sent a letter to the Prime Minister in order to suggest that the project should be cancelled definitively. His arguments were based on a fascinating description of what transport needs should be in the future and have actually become on. In France as well as in Germany, from the '70s onwards, the waterborne market share is on a decreasing trend. The only efficient part of the waterborne network is the part free of lock, one on which freight prices are competitive enough compared with railway prices thus balancing a lower commercial speed. But when locks density increases, the commercial speed on rivers decreases lower and lower while operating costs are necessary increase. With one lock every 10 km, and even more, the Rhine-Rhone Canal will be a weak competitor of the railway which offers already a capacity several times more important than the future capacity of the canal. The Rhine shipping route and the lessons that can be drawn from it, as well as the example of the Rhine-Main-Danube Canal, are frequently used by the Rhine-Rhone lobby in the French debate. On the contrary, the technical and economic comparisons show that the German example proves the poor interest of the very costly French project. In addition, this paper presents the stratagems by which politicians were deceived despite several official forecasts and evaluation studies.
A New Approach to Reducing Social Engineering Impact

In recent years, the security research community has been very active in proposing different techniques and algorithms to face the proliferating security vulnerabilities. However, social engineering remains an alarming threat to the most secured networks. Security administrators are certainly aware of the gravity of the human factor, whatever is the strength of the technological measures. The human factor is still a difficult-to-surround notion and a difficult to quantify concept. It is rarely considered in the early stages of the development lifecycle of software, assuming traditional security considerations have been taken into account. In this chapter, we discuss the added-value of context as a way to deal with social engineering. Based on a case study describing a typical attack, we provide a first attempt to model this parameter.
Terrorist Learning: A New Analytical Framework

ABSTRACT Terrorists learn every day to gain further knowledge on how to achieve their violent objectives. Consequently, understanding terrorist learning forms a crucial part of the fight to counter terrorism. However, while existing literature within terrorism studies has examined a number of different parts of the learning process, there currently fails to exist a comprehensive framework to encompass the learning process as a whole. This article will rectify this oversight by drawing on wider learning literature to develop a new analytical framework for terrorist learning that provides a definition, considers the actors involved and identifies processes and outcomes. Consequently, the full landscape of current and potential research in this important area is revealed.
lookedup4you: Mikrostruktur und Makrostruktur und all das: Erfahrungen mit der Produktion eines Online-Nachschlagewerks als studentisches Projekt

Students of the department of library and information science at the University of Applied Sciences Hamburg produced on behalf of the consumer advice center North Rhine-Westphalia an online reference work for young persons addressing diverse questions of consumer protection and consumer rights from the perspective of adolescents. All steps of the production of an online reference work from the creation of a user model, the gathering of content, the development of an information-architecture to the creation of an appealing interface-design are described. In their lessons learned the two participating professors/project managers come to the conclusion that the production of an online reference work offers an ideal case study for a holistic project in the complex field of knowledge organization. However, for the success of a reference work project the following accompanying measures should be taken:provision of institutionalized knowledge-transferbetween workgroups, regular work reports and group meetings, reliable time management and workshops. Phases of concentrated production should be followed by phases of common reflection.
LFA-1 Mechanotransduced via High-Affinity Migrational Guidance of Neutrophils Is

Acute inﬂammation triggers the innate immune response of neutrophils that efﬁciently trafﬁc from the bloodstream to concentrate at high numbers at the site of tissue infection or wounding. A gatekeeper in this process is activation of b 2 integrins, which form bond clusters with ICAM-1 on the endothelial surface. These bond clusters serve dual functions of providing adhesive strength to anchor neutrophils under the shear forces of blood ﬂow and directional guidance for cell polarization and subsequent transmigration on inﬂamed endothelium. We hypothesized that shear forces transmitted through high-afﬁnity LFA-1 facilitates the cooperation with the calcium release-activated channel Orai1 in directing localized cytoskeletal activation and directed migration. By using vascular mimetic microﬂuidic channels, we observed neutrophil arrest on a substrate of either ICAM-1 or allosteric Abs that stabilize a high- or low-afﬁnity conformation of LFA-1. Neutrophils captured via low-afﬁnity LFA-1 did not exhibit intracellular calcium ﬂux, F-actin polymerization, cell polarization, or directional migration under shear ﬂow. In contrast, high-afﬁnity LFA-1 provided orientation along a uropod–pseudopod axis that required calcium ﬂux through Orai1. We demonstrate how the shear stress of blood ﬂow can transduce distinct outside–in signals at focal sites of high-afﬁnity LFA-1 that provide contact-mediated guidance for neutrophil emigration. The Journal of Immunology , 2011, 187: 000–000. ydrodynamic shear stress is an omnipresent and necessary component of the multistep process of leukocyte recruitment providing mechanical forces that act on leukocyte adhesion receptors following contact with the vessel wall. E-selectin and L -selectin to a high-afﬁnity state and binding of integrins with ICAM-1 on inﬂamed endothelium. As LFA-1/ICAM-1 bonds take up tensile forces they colocalize with Orai1 and facilitate cooperation with IP 3 mediated calciosomes to activate calcium ﬂux, which in turn catalyzes recruitment of Rap-1 GTPases and cytoskeletal elements such as Talin to LFA-1 cytodomains to direct pseudopod projection. C , Shape polarization is guided locally by the dynamic redistribution of LFA-1/ICAM-1 clusters, Orai1, and assembly of the F-actin cytoskeleton, which drives directional migration in a manner dependent on direction of shear stress.
Erzeugung präziser Referenzdaten für die 3D-Kopfposenschätzung

Zusammenfassung In dieser Arbeit wird eine Methode zur Erzeugung von Referenzdaten für die 3D-Kopfposenschätzung mit Hilfe eines Vicon MX Motion-Capture-Systems vorgestellt. Im Rahmen der Arbeit wurden jeweils 22 Videos von sechs Probanden mit einer handelsüblichen RGB-Kamera mit einer Frequenz von 30 Bildern pro Sekunde aufgenommen. Die Videosequenzen zeigen Szenarien, welche aus Drehbewegungen des Kopfes um die drei Raumachsen unter verschiedenen Beleuchtungsbedingungen bestehen. Die Videos wurden mit einer Auflösung von 800 × 600 Bildpunkten im RGB24-Format aufgenommen, welche eine weitere Bildverarbeitung zur Detektion charakteristischer Merkmale zulässt. Über die Referenzdaten der Kopfposition hinaus wurden Informationen über die Blickrichtung der Probanden aufgezeichnet, indem die Probanden aufgefordert wurden, Punkte bekannter Koordinaten auf einem Bildschirm zu verfolgen. Dieser Beitrag liefert eine detaillierte Beschreibung des Messaufbaus und der Durchführung. Ziel ist es eine Methode vorzustellen, um aus den 3D-Trajektorien der Marker des Motion-Capture-Systems Referenzdaten für den Zustandsvektor des Kopfes zu bestimmen. Darüber hinaus wird ein mit der vorgestellten Methode erzeugter Datensatz zur Validierung von erscheinungsbasierten Algorithmen zur Kopfposenschäztung bereitgestellt.
The business impact of information systems : a unified theory and empirical test

Past research in information technology (IT) has yielded many competing models and different antecedents of IT acceptance have been proposed and analysed (Venkatesh et al., 2003). Especially in these times, when considering “the unprecedented decline of the global economy is impacting the IT industry with worldwide IT spending forecast to total $3.2 trillion in 2009, a 3.8 per cent decline from 2008 revenue of nearly $3.4 trillion” (Gartner, 2009) it is of vital relevance to estimate as accurate as possible the returns and risks involved in IT investments. In their systematic and comprehensive analysis, in which they “use a combination of quantitative and qualitative techniques”, Moody et al. (2009) identify the top 5 most influential core theories of the Information Systems (IS) field. These theories currently dominate the IS field in explaining the acceptance and adoption of IT investments. However, as this thesis points out, the existing theories contradict at some critical points. Additionally, there is a significant overlap between the theories. Finally some of the theories seem to lack a consistent operationalization in order to make it applicable in an empirical context. This thesis presents a new, comprehensive theory that explains and predicts the acceptance of information systems, as well as the (financial) returns or business impact. The theory is called: Unified Theory of Information System Success (UTISS) The overall goal of this Masters Thesis is (1) to formulate the UTISS theory that unifies the current IS paradigms: the Technology Acceptance Model, the IS Success Model, the Task to Performance Chain, and the Unified Theory of Acceptance and Use of Technology, (2) to extent its foundations by including other reference disciplines (i.e. marketing and software engineering), and (3) to empirical validate UTISS. After presenting the comprehensive model, a combination of qualitative and quantitative techniques are used to show that (1) the UTISS model is sufficiently operationalized and hence can be applied meaningful to empirical contexts, and (2) the theory appears to be useful in assessing current IS implementations. During their extensive longitudinal healthcare investigation, Devaraj & Kohli (2003) proposed and concluded that “the driver of IT impact is not the investment in technology, but the actual usage of the technology”. The findings in this thesis support their conclusion as well as their suggestion that careful investigation and estimation of IT usage is relevant, especially for those who are practically involved in IT projects.
A Case of Neuropsychiatric Systemic Lupus Erythematosus With Hair Loss as the First Diagnostic Symptom

Neuropsychiatric systemic lupus erythematosus is a serious complication of systemic lupus erythematosus. A 33-year-old female patient had repeated hair loss for more than 3 years. A dermatologic examination showed several pieces of irregularly shaped hair loss patterns in the center of the patient's scalp. The systemic treatment included oral hydroxychloroquine, aspirin enteric-coated tablets and prednisone, and intrathecal injection of dexamethasone and methotrexate. The local treatment included intralesional injection of triamcinolone acetonide and lidocaine in the lesion area, 0.1% tacrolimus ointment for external use. After 2-month treatment, hair regrew in a non-scarring patchy alopecia region with no further hair loss.
In Silico Integration of Transcriptome and Interactome Predicts an ETP-ALL-Specific Transcriptional Footprint that Decodes its Developmental Propensity

Early T precursor acute lymphoblastic leukemia (ETP-ALL) exhibits poor clinical outcomes and high relapse rates following conventional chemotherapeutic protocols. Extensive developmental flexibility of the multipotent ETP-ALL blasts with considerable intra-population heterogeneity in terms of immunophenotype and prognostic parameters might be a target for novel therapeutic interventions. Using a public gene expression dataset (GSE28703) from NCBI GEO DataSets with 12 ETP-ALL and 40 non-ETP-ALL samples, such heterogeneity was found to be reflected in their transcriptome as well. Hub genes were identified from the STRING-derived functional interaction network of genes showing differential expression between ETP-ALL and non-ETP-ALL as well as variable expression across ETP-ALL. Nine genes (KIT, HGF, NT5E, PROM1, CD33, ANPEP, CDH2, IL1B, and CXCL2) among the hubs were further validated as possible diagnostic ETP-ALL markers using another gene expression dataset (GSE78132) with 17 ETP-ALL and 27 non-ETP-ALL samples. Linear dimensionality reduction analysis with the expression levels of the hub genes in ETP-ALL revealed their divergent inclinations towards different hematopoietic lineages, proposing them as novel indicators of lineage specification in the incompletely differentiated ETP-ALL blasts. This further led to the formulation of a personalized lineage score calculation algorithm, which uncovered a considerable B-lineage-bias in a substantial fraction of ETP-ALL subjects from the GSE28703 and GSE78132 cohorts. In addition, STRING-derived physical interactome of the potential biomarkers displayed complete segregation of the B-lineage-skewed markers from other lineage-associated factors, highlighting their distinct functionality and possible druggability in ETP-ALL. A panel of these biomarkers might be useful in pinpointing the dominant lineage specification programmes in the ETP-ALL blasts on a personalized level, urging the development of novel lineage-directed precision therapies as well as repurposing of existing therapies against leukemia of different hematopoietic lineages; which might overcome the drawbacks of conventional chemotherapy.
Morphing wing optimization for steady level flight

This paper presents the basic results of the morphing wing planform optimization of an experimental unmanned air vehicle for minimum drag at steady level flight. The aerodynamic design tool that consists of the three-dimensional panel method, two-dimensional boundary layer solution and generalized reduced gradient method-based optimization is appropriate for fixed wing and morphing wing conceptual and preliminary design. The morphing concept is implemented into the solution with the geometric constraints of the wing planform and the airfoil shape design variables. The drag that is created by other components of the aircraft is calculated according to empirical formulas. Wing drag and aircraft drag comparisons between baseline wing (BASE), optimum fixed wing and morphing wing are discussed with the obtained planform and airfoil shapes.
Local monitoring by low cost devices and free and open sources softwares

The purpose of local monitoring is to closely model displacements, evolution and deformations of civil engineering structures and model local phenomena like landslides. For certain applications, latency of the monitoring results is not a crucial point. In other cases a small latency is fundamental: for example, a suspected Alpine landslide that insists on villages. In these cases, contiunous quasi real time monitoring by permanent stations is required. Here, a typical monitoring configuration is given by a GNSS reference permanent station, outside the monitored area, in a stable site and several permanent stations in the monitored area. Data can be processed and the results can be monitored in a quasi continuous way by automated procedures. In these situations, the use of low cost GNSS receivers could be interesting because it can significantly increase the number of monitored points without notably increasing the network cost. This investigation is the scope of our work and several experiments have been set up and performed to assess them. To reach our goals, geodetic and low cost receivers are teamed up: Leica GR10 as reference station and several single frequency u-blox 7P receivers. Once the aquisition phase is completed data are processed with commercial (Leica GeoOffice), academic (Bernese) and free and open source softwares (goGPS and RTKLIB). The results are compared in the final step of the project, accuracy and reliability of solutions are discussed. Their results will be described in the presentation and the full paper.
AN ERYTHEMATO SQUAMOUS DISEASE (ESD) DETECTION USING DBN TECHNIQUE

ESD is a serious type of skin disease that increases over the past decades in the world and as a sequel to curing strategy in the medical field, automatic detection of ESDs using dermoscopic images has been still challenging and complicated task. This kind of difficulty occurs in the diagnosis of ESD owing to the following factors such as indistinct ESD borders, poor color contrast, location-dependent, shape variations, and complex structures of the ESDs. The progressing public health burden issues have to be detected early and treated in proper ways to prevent further spreading to other organs of the body through which medical professionals and researchers can save several lives. When there is an abnormal change in the appearance of the skin, then there is a chance for the subject that may be affected by ESD. To obtain better solutions, the computer vision methods must be paired with dermatology knowledge for efficient ESD detection. Hence, it is important to develop Deep Belief Network (DBN) based detection techniques to assist clinicians to diagnose ESD at early stages.
Effect of Temperature and Relative Humidity on Onion farms and its Monitoring by using IoT Based Smart Farming System

Onion cultivation in many parts of India and Karnataka State have affected by a rapid change in the climatic conditions. The objective of this research paper is to analyse the effect of volatile atmospheric conditions such as temperature and relative humidity (RH) in open and greenhouse farming on onion cultivation and provide an early alert to maintain a favourable environment for better yielding of onion by using a smart farming system. The smart farming system developed by using IoT, is built for monitoring the onion crop with the help of different types of sensors. The data gathered by these sensors are analysed to assess the favourable and adverse effect of the climatic parameters on the onion crop and making decisions for the cultivation of crops or maintain favourable environmental conditions in a greenhouse to minimize the loss due to crop failure. The system also provides an early information to the farmers about the variations in environmental factors and their effect on the crop in different stages of its growth. For an onion crop the variations of these parameters cause the bolting. This unfavourably conditions effect on the quality of the onion produced. The smart framing system proposed is suitable for monitoring the changes in the environmental factors, and to analyse the effect of these parameters both in a greenhouse and open environment. The result obtained by experiments of this research specifies that the percentage bolting is more in an open environment than a greenhouse. The greenhouse will produce a better yielding due to controlled parameters.