Miracle-dz/UniFAR-FTUs huggingface dataset:
Bacterial Pathogens in the Food Industry: Antibiotic Resistance and Virulence Factors of Salmonella enterica Strains Isolated from Food Chain Links

Salmonella is one of the most important foodborne pathogens. Fifty-three strains of Salmonella deposited in the Culture Collection of Industrial Microorganisms—Microbiological Resources Center (IAFB) were identified using molecular and proteomic analyses. Moreover, the genetic similarity of the tested strains was determined using the PFGE method. Main virulence genes were identified, and phenotypical antibiotic susceptibility profiles and prevalence of resistance genes were analyzed. Subsequently, the occurrence of the main mechanisms of β-lactam resistance was determined. Virulence genes, invA, fimA, and stn were identified in all tested strains. Phenotypic tests, including 28 antibiotics, showed that 50.9% of the strains were MDR. The tet genes associated with tetracyclines resistance were the most frequently identified genes. Concerning the genes associated with ESBL-producing Salmonella, no resistance to the TEM and CTX-M type was identified, and only two strains (KKP 1597 and KKP 1610) showed resistance to SHV. No strains exhibited AmpC-type resistance but for six Salmonella strains, the efflux-related resistance of PSE-1 was presented. The high number of resistant strains in combination with multiple ARGs in Salmonella indicates the possible overuse of antibiotics. Our results showed that it is necessary to monitor antimicrobial resistance profiles in all food chain links constantly and to implement a policy of proper antibiotic stewardship to contain or at least significantly limit the further acquisition of antibiotic resistance among Salmonella strains.
Infra-quantum mechanics and critical examination of Bell's theorem on locality The principles of a revolution of epistemology revealed in the descriptions of microstates

This is an improved remake of a previous work submitted with the same title. An epistemologicalphysical, strictly qualitative discipline, IQM (infra-quantum mechanics), is constructed independently of the mathematical formalism of QM. IQM emerges under exclusively the constraints imposed by: the cognitive situation of a human being who decides to construct communicable and consensual knowledge on microstates; general requirements of human conceptualization. IMQ brings into evidence how the mathematical formalism of QM manages to signify. It explicates an integrated expression of a radically new type of descriptional form, transferred on the registering devices of macroscopic apparatuses and primordially statistical. IMQ is then considered globally and its relations with space, time, geometry, consensus, as well as with Einstein's theories, are specified. It appears that: there exists an order of progressive constructability of our conceptualizations of physical reality; this order withstands inclusion of concepts constructed inside macroscopic physics, into the primordial transferred representation of microstates; consequently the aim of directly unifying Einstein's theories, with QM, appears to be impossible. Bell's theorem on locality expresses exclusively this impossibility. Causality appears to be a modelizing concept that cannot be implemented into our primordial representations of physical entities.
Oviposition behaviour in Drosophila melanogaster: Genetic and behavioural decoupling between oviposition acceptance and preference for natural fruits

In phytophagous insects, oviposition behaviour is an important component of habitat selection and, given the multiplicity of genetic and environmental factors affecting its expression, is defined as a complex character resulting from the sum of interdependent traits. Here, we study two components of egg‐laying behaviour: oviposition acceptance (OA) and oviposition preference (OP) in Drosophila melanogaster using three natural fruits as resources (grape, tomato and orange) by means of no‐choice and two‐choice experiments, respectively. This experimental design allowed us to show that the results obtained in two‐choice assays (OP) cannot be accounted for by those resulting from no‐choice assays (OA). Since the genomes of all lines used are completely sequenced, we perform a genome‐wide association study to identify and characterize the genetic underpinnings of these oviposition behaviour traits. The analyses revealed different candidate genes affecting natural genetic variation of both OA and OP traits. Moreover, our results suggest behavioural and genetic decoupling between OA and OP and that egg‐laying behaviour is plastic and context‐dependent. Such independence in the genetic architectures of OA and OP variation may influence different aspects of oviposition behaviour, including plasticity, canalization, host shift and maintenance of genetic variability, which contributes to the adoption of adaptive strategies during habitat selection.
Enhancement of axion decay constants in type IIA theory?

We investigate the possibility of enhancement of effective axion decay constant in well controlled constructions in string theory. To this end, we study the dynamics of axions arising in the compactifications of type IIA string theory on Calabi-Yau orientifolds with background fluxes (with non-perturbative effects included to ensure stabilization of all moduli). In this setup, we attempt to obtain large effective axion decay constant in two different ways: by searching for a direction in field space in which the potential is sufficiently flat and by arriving at a very explicit stringy embedding of the Kim-Nilles-Peloso (KNP) alignment mechanism. We do not find super-Planckian effective decay constants by either of the approaches. Furthermore, we find that the alignment angle of KNP mechanism can not be made arbitrarily small by adjusting the fluxes.
On gravitational interactions for massive higher spins in AdS3

In this paper we investigate gravitational interactions of massive higher spin fields in three dimensional AdS space with arbitrary value of cosmological constant including flat Minkowski space. We use the frame-like gauge description for such massive fields adapted to the three-dimensional case. First, we carefully analyze the procedure of switching on gravitational interactions in the linear approximation in the example of a massive spin-3 field and then proceed with the generalization to the case of an arbitrary integer spin field. As a result we construct a cubic interaction vertex linear in a spin-2 field and quadratic in a higher spin field on the AdS3 background. As in the massless case the vertex does not contain any higher derivative corrections to the Lagrangian and/or gauge transformations. Thus, even after switching on gravitational interactions, one can freely consider any massless or partially massless limits as well as the flat one. This article is part of a special issue of Journal of Physics A: Mathematical and Theoretical devoted to ‘Higher spin theories and holography’.
Interacting supernovae and supernova impostors. SN 2007sv: the major eruption of a massive star in UGC 5979

We report the results of the photometric and spectroscopic monitoring campaign of the transient SN 2007sv. The observables are similar to those of Type IIn supernovae, a well-known class of objects whose ejecta interact with pre-existing circumstellar material (CSM). The spectra show a blue continuum at early phases and prominent Balmer lines in emission; however, the absolute magnitude at the discovery of SN 2007sv (M-R=-14.25 +/- 0.38) indicate it to be most likely a supernova impostor. This classification is also supported by the lack of evidence in the spectra of very high velocity material as expected in supernova ejecta. In addition, we find no unequivocal evidence of broad lines of alpha- and/or Fe-peak elements. The comparison with the absolute light curves of other interacting objects (including Type IIn supernovae) highlights the overall similarity with the prototypical impostor SN 1997bs. This supports our claim that SN 2007sv was not a genuine supernova, and was instead a supernova impostor, most likely similar to the major eruption of a luminous blue variable.
The Extension of Surgery Predicts Acute Postoperative Pain, While Persistent Postoperative Pain Is Related to the Spinal Pathology in Adolescents Undergoing Posterior Spinal Fusion

Persistent pain after posterior spinal fusion affects 12 to 42% of patients with adolescent idiopathic scoliosis. The incidence of persistent pain among surgically treated children with Scheuermann kyphosis and spondylolisthesis is not known. The aim of our study was to determine the predictors and incidence of acute and chronic postoperative pain in adolescents undergoing posterior spinal fusion surgery. The study was a retrospective analysis of a prospectively collected pediatric spine register data. The study included 213 consecutive patients (158 AIS, 19 Scheuermann kyphosis, and 36 spondylolisthesis), aged 10–21 years undergoing posterior spinal fusion at a university hospital between March 2010 and March 2020. The mean (SD) daily postoperative opioid consumption per kilogram was significantly lower in the spondylolisthesis patients 0.36 mg/kg/day (0.17) compared to adolescent idiopathic scoliosis 0.51 mg/kg/day (0.25), and Scheuermann kyphosis 0.52 mg/kg/day (0.25) patients after surgery (p = 0.0004). Number of levels fused correlated with the daily opioid consumption (rs = 0.20, p = 0.0082). The SRS-24 pain domain scores showed a statistically significant improvement from preoperative levels to two-year follow-up in all three groups (p ≤ 0.03 for all comparisons). The spondylolisthesis patients had the lowest SRS pain domain scores (mean 4.04, SD 0.94), reporting more pain two years after surgery, in comparison to AIS (mean 4.31, SD 0.60) (p = 0.043) and SK (mean 4.43, SD 0.48) patients (p = 0.049). Persistent postoperative pain in adolescents undergoing posterior spinal fusion is related to disease pathology while higher acute postoperative pain is associated with a more extensive surgery. Spondylolisthesis patients report more chronic pain after surgery compared to AIS and SK patients.
The role of the inner disk in mass accretion to the star in the early phase of star formation

A physical mechanism that drives FU Orionis-type outbursts is reconsidered. We study the effect of inner part of a circumstellar disk covering a region from near the central star to the radius of approximately $5$ AU (hereafter, the inner disk). Using the fluctuated mass accretion rate onto the inner disk $\dot{M}_{\rm out}$, we consider the viscous evolution of the inner disk and the time variability of the mass accretion rate onto the central star $\dot{M}_{\rm in}$ by means of numerical calculation of an unsteady viscous accretion disk in a one-dimensional axisymmetric model. First, we calculate the evolution of the inner disk assuming an oscillating $\dot{M}_{\rm out}$. It is shown that the time variability of $\dot{M}_{\rm in}$ does not coincide with $\dot{M}_{\rm out}$ due to viscous diffusion. Second, we investigate the properties of spontaneous outbursts with temporally constant $\dot{M}_{\rm out}$. Outburst occur only in a limited range of mass accretion rates onto the inner disk $10^{-10}<\dot{M}_{\rm out}< 3\times 10^{-6}~{\rm M}_{\odot} {\rm yr}^{-1}$ due to gravo-magneto limit cycle (GML). Finally, we discuss the case with a combination of episodic $\dot{M}_{\rm out}$ and accretion outbursts cause by the GML in the inner disk. The GML can drive accretion outbursts onto the star even for the case of fluctuating $\dot{M}_{\rm out}$, although fluctuations of $\dot{M}$ decay during transmitting the inner disk inwards. We newly identified two modes of outburst which are spontaneous one and stimulated one. In a stimulated mode of outburst, $\dot{M}_{\rm out}$ does appear directly in $\dot{M}_{\rm in}$ (the latter defining the stellar accretion luminosity). In a spontaneous mode of outburst, $\dot{M}_{\rm out}$ appears as the interval between outbursts.
STAR-FORMING GALAXIES AS THE ORIGIN OF THE ICECUBE PeV NEUTRINOS

Star-forming galaxies, due to their high star formation rates, and hence large number of supernova remnants (SNRs) therein, are huge reservoirs of cosmic rays (CRs). These CRs collide with gases in galaxies and produce high-energy neutrinos through proton–proton collisions. In this paper, we calculate the neutrino production efficiency in star-forming galaxies by considering realistic galaxy properties, such as the gas density and galactic wind in star-forming galaxies. To calculate the accumulated neutrino flux, we use the infrared luminosity function of star-forming galaxies recently obtained by the Herschel PEP/HerMES survey. The intensity of CRs producing PeV neutrinos in star-forming galaxies is normalized with the observed CR flux at EeV (1 EeV = 10 18 ? > eV), assuming that SNR or hypernova remnants in star-forming galaxies can accelerate protons to EeV energies. Our calculations show that the accumulated neutrino emission produced by CRs in star-forming galaxies can account for the flux and spectrum of the sub-PeV/PeV neutrinos under reasonable assumptions on the CR confinement time in these galaxies.
The Progress of Non-Viral Materials and Methods for Gene Delivery to Skeletal Muscle

Since Jon A. Wolff found skeletal muscle cells being able to express foreign genes and Russell J. Mumper increased the gene transfection efficiency into the myocytes by adding polymers, skeletal muscles have become a potential gene delivery and expression target. Different methods have been developing to deliver transgene into skeletal muscles. Among them, viral vectors may achieve potent gene delivery efficiency. However, the potential for triggering biosafety risks limited their clinical applications. Therefore, non-viral biomaterial-mediated methods with reliable biocompatibility are promising tools for intramuscular gene delivery in situ. In recent years, a series of advanced non-viral gene delivery materials and related methods have been reported, such as polymers, liposomes, cell penetrating peptides, as well as physical delivery methods. In this review, we summarized the research progresses and challenges in non-viral intramuscular gene delivery materials and related methods, focusing on the achievements and future directions of polymers.
Modelling Fast-Alfvén Mode Conversion Using SPARC

We successfully utilise the SPARC code to model fast-Alfvén mode conversion in the region cA >> cs via 3-D MHD numerical simulations of helioseismic waves within constant inclined magnetic field configurations. This was achieved only after empirically modifying the background density and gravitational stratifications in the upper layers of our computational box, as opposed to imposing a traditional Lorentz Force limiter, to ensure a manageable timestep. We found that the latter approach inhibits the fast-Alfvén mode conversion process by severely damping the magnetic flux above the surface.
Zinc Chloride Enhances the Antioxidant Status, Improving the Functional and Structural Organic Disturbances in Streptozotocin-Induced Diabetes in Rats

Background and Objectives: Diabetes mellitus (DM) is a complex disease affecting the whole metabolic balance of the body and resulting in multiple organ complications: cardiovascular, neuronal, renal, etc. Our study focuses on investigating the effect of zinc chloride (Zn) on certain blood parameters suggestive for assessing the metabolic disturbances, the liver and kidney function, the oxidative stress and the immune defense capacity in experimental-induced DM with streptozotocin (STZ) and cholesterol in rats. Materials and Methods: The animals were assigned to three groups, as follows: Group 1 (Control): buffer citrate solution 0.1 mL/100 g body; Group 2 (STZ): 20 mg/kg body STZ and fat diet (10 g cholesterol/100 g diet); Group 3 (STZ+Zn): 20 mg/kg body STZ + 5 mg/kg body Zn chloride and the same fat diet. DM was induced by administering STZ in a single take daily, for three consecutive days, Zn and citrate buffer were administered orally for a month. The protocol was approved by the Ethics Committee of the University ‘Grigore T Popa’ Iasi, in agreement with the International Regulations about the handling of laboratory animals. Results: The use of STZ in rats fed with cholesterol was correlated with important weight gain, hyperglycemia, the intensification of the transaminases activity and the increase in serum alkaline phosphatase, cholesterol, triglyceride, urea, creatinine and in malondialdehyde. Conclusions: The treatment with Zn resulted in weight loss and a decrease in blood sugar in diabetic rats. Supplementation with Zn notably reduced oxidative stress, preserved the pancreatic architecture and restored the liver and kidney function and structure in STZ-induced DM in rats.
The Use of Medicinal Plant-Derived Metallic Nanoparticles in Theranostics

In the quest to effectively diagnose and treat the diseases that afflict mankind, the development of a tool capable of simultaneous detection and treatment would provide a significant cornerstone for the survival and control of these diseases. Theranostics denotes a portmanteau of therapeutics and diagnostics which simultaneously detect and treat ailments. Research advances have initiated the advent of theranostics in modern medicine. Overall, theranostics are drug delivery systems with molecular or targeted imaging agents integrated into their structure. The application of theranostics is rising exponentially due to the urgent need for treatments that can be utilized for diagnostic imaging as an aid in precision and personalised medicine. Subsequently, the emergence of nanobiotechnology and the green synthesis of metallic nanoparticles (MNPs) has provided one such avenue for nanoscale development and research. Of interest is the drastic rise in the use of medicinal plants in the synthesis of MNPs which have been reported to be potentially effective in the diagnosis and treatment of diseases. At present, medicinal plant-derived MNPs have been cited to have broad pharmacological applications and have been studied for their potential use in the treatment and management of cancer, malaria, microbial and cardiovascular diseases. The subject of this article regards the role of medicinal plants in the synthesis of MNPs and the potential role of MNPs in the field of theranostics.
Identification and Quantification of Key Phytochemicals, Phytohormones, and Antioxidant Properties in Coccinia grandis during Fruit Ripening

Coccinia grandis contains secondary metabolites, such as flavonoids, phenolic acids, terpenoids, alkaloids, sterols, and glycosides, which are known to have in vitro antioxidant, antidiabetic, anti-inflammatory, and antidyslipidemic activities. C. grandis fruits change dramatically during ripening, and the differences in the phytochemicals contribute to various uses. This study reports the phytochemical compounds and antioxidant activities during ripening of C. grandis for the first time. Characterizations were conducted on the physiologically active substances in C. grandis fruits at three ripening stages, and a total of 25 peaks were identified. Key phytochemicals in the ripening stages of C. grandis were identified, and the major substances that contributed to antioxidant properties were selected and quantitatively analyzed. Although the concentration of tiliroside increased during aging, hydroxycinnamic acid (chlorogenic and p-coumaric acids), flavonols (rutin), and triterpenes (cucurbitacins B and D) with antioxidant effects decreased. Therefore, phenolic compounds and cucurbitacins dominate immature C. grandis quantitatively. Regarding phytohormones, the gibberellin A4 content decreased as the fruits matured, but indoleacetic acid and salicylic acid increased with fruit maturity. The antioxidant capacities determined by DPPH and ABTS consistently decreased with increasing maturity. Accordingly, the extracts of immature C. grandis fruits have high levels of bioactive compounds and can be used to develop food additives and health supplements.
Why Are Peculiar Type Ia Supernovae More Likely to Show the Signature of a Single-degenerate Model?

Although type Ia supernovae (SNe Ia) are very useful in many astrophysical fields, their exact progenitor nature is still unclear. A basic method to distinguish the different progenitor models is to search the signal from the single-degenerate (SD) model, e.g., the signal for the existence of a nondegenerate companion before or after supernova explosion. Observationally, some SNe Ia show such signals, while the others do not. Here, we propose a universal model to explain these observations based on the spin-up/spin-down model, in which a white dwarf (WD) will experience a spin-down phase before supernova explosion, and the spin-down timescale is determined by its initial mass, i.e., the more massive the initial WD, the shorter the spin-down timescale and then the more likely the SN Ia is to show the SD signature. Therefore, our model predicts that the SNe Ia from hybrid carbon–oxygen–neon WDs are more likely to show the SD signature observationally, as some peculiar SNe Ia showed.
Charged current neutrino interactions in hot and dense matter

We derive the charged current absorption rate of electron and anti-electron neutrinos in dense matter using a fully relativistic approach valid at arbitrary matter degeneracy. We include mean field energy shifts due to nuclear interactions and the corrections due to weak magnetism. The rates are derived both from the familiar Fermi's Golden Rule, and from the techniques of finite temperature field theory, and shown to be equivalent. In various limits, these results can also be used to calculate neutral current opacities. We find that some pieces of the response have been left out in previous derivations and their contribution at high density can be significant. Useful formulae and detailed derivations are presented and we provide a new open source implementation of these opacities for use in radiation hydrodynamic simulations of core-collapse supernovae and neutron star mergers.
The Association Between Child Abuse and Aggressive Behavior: A Three-Level Meta-Analysis

Child abuse is considered to be an essential factor in the development of aggressive behavior. The intensity of the positive relations between child abuse and aggressive behavior differed considerably among researches despite the fact that abundant studies have observed this relation. According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) approach, a three-level meta-analysis was employed to obtain reliable estimates for the sizes of effects and investigate some potential moderators of the relation between child abuse and aggressive behavior. The present study obtained 51 studies (30,566 participants; 680 effect sizes) through performing the detailed literature search. It was found that child abuse was positively associated with aggressive behavior in the current study. In addition, the present meta-analysis observed significant moderating effects for type of child abuse, culture, measurement of child abuse, and publication year in the association between child abuse and aggressive behavior. This study suggests that child abuse is a predictor for the development of aggressive behavior in humans. Moreover, child abuse is an important aspect for consideration in efforts toward strengthening of interventions targeting individuals’ aggressive behavior.