Miracle-dz/UniFAR-FTUs huggingface dataset:
Enthesopathy, a Cause for Persistent Peristomal Pain after Treatment with an Osseointegrated Bone-Anchor: A Retrospective Case Series

ABSTRACT Introduction After limb loss, many patients undergo treatment with an osseointegrated implant. Unfortunately, some develop persistent peristomal pain after surgery. This can be sufficiently severe to reduce the speed of their rehabilitation or may halt the process altogether. The pain may be due to an enthesopathy of the residual muscles. We describe the phenomenon and outcomes of treatment in a series of patients who underwent treatment with an osseointegrated prosthetic limb, bone-anchor. Materials and Methods Over 36 months, we followed 14 patients with symptoms consistent with enthesopathy. Thirteen had undergone treatment with a transfemoral bone-anchor and one underwent treatment with a transhumeral bone-anchor. One patient had a bilateral transfemoral amputation. Analysis of the patients' ages, heights, weight at the time of surgery, length of residual femur, or preoperative dual-energy x-ray absorptiometry scans showed no correlation with the development of enthesopathy pain. Thirteen patients received steroid injections. Most received at least one injection of Adcortyl™ and bupivacaine. Patients were then encouraged to follow a program of physiotherapy to stretch out their enthesis, after injection. Results All patients experienced relief from their symptoms, but only two were rendered completely pain free. The remaining 11 patients gained sufficient control of their symptoms to allow them to continue daily use of their prosthesis with less difficulty or, where rehabilitation had been delayed or halted completely, to resume this process. Conclusion Enthesopathy seems to be a common phenomenon after bone-anchor surgery in individuals with transfemoral amputation. Steroid injections can help to relieve pain, allowing physiotherapy to be carried out. Patients undergoing treatment with a bone-anchor should be advised of the possibility of enthesopathy pain but can be reassured that there is a solution that works well in most cases. Clinical Relevance This article may be of benefit to clinicians who are struggling to manage patients with persistent peristomal pain after insertion of a bone-anchor. It may also encourage further research into measures for securing the soft tissues around the stoma for patients undergoing bone-anchor surgery.
A UWB-Based Lighter-Than-Air Indoor Robot for User-Centered Interactive Applications

Features such as safety and longer flight times render lighter-than-air robots strong candidates for indoor navigation applications involving people. However, the existing interactive mobility solutions using such robots lack the capability to follow a long-distance user in a relatively larger indoor space. At the same time, the tracking data delivered to these robots are sensitive to uncertainties in indoor environments such as varying intensities of light and electromagnetic field disturbances. Regarding the above shortcomings, we proposed an ultra-wideband (UWB)-based lighter-than-air indoor robot for user-centered interactive applications. We developed the data processing scheme over a robot operating system (ROS) framework to accommodate the robot’s integration needs for a user-centered interactive application. In order to explore the user interaction with the robot at a long-distance, the dual interactions (i.e., user footprint following and user intention recognition) were proposed by equipping the user with a hand-held UWB sensor. Finally, experiments were conducted inside a professional arena to validate the robot’s pose tracking in which 3D positioning was compared with the 3D laser sensor, and to reveal the applicability of the user-centered autonomous following of the robot according to the dual interactions.
Water resources system operation optimization analysis during drought based on risk index

According to the characteristic of water resources system operation performance analysis during drought, a multi-objective mixed integer programming model is established, which is based on the principle that the reliability and resilience are maximized, and the vulnerability of reservoir water supply is minimized. Meanwhile, the priority among urban water-supply, agricultural water-supply and so on is considered. In the study of a real system operation, the satisfying trade-off solution of multi-objective decision model is obtained by evaluating the Euclidian distance between some actual objective point and the ideal point. Computing results show the feasibility and effectiveness of practical application of the multi-objective mixed integer programming model on the reservoir operation policy analysis that considering the priority of several water-supply types during drought periods.
2D Materials for Wearable Energy Harvesting

The growing demand for energy in wearable sensors and portable electronics necessitates the development of self‐contained, sustainable, and mobile power sources capable of harvesting environmental energies. Researchers have made significant strides in implementing photovoltaics, thermoelectrics, piezoelectrics, and triboelectrics in 2D materials. This has resulted in significant advancements in wearable energy harvesting systems based on 2D materials. This review discusses the relationship between synthesis procedures, material structures/properties, and device performance in the context of 2D materials‐based wearable energy harvesting technologies. Finally, challenges and future research opportunities are identified and discussed based on current progress.
The influence of intermittent apnea on aortic hemodynamics in healthy young men

Background: Sleep apnea is known as a high-risk factor for cardiovascular disease (CVD); However, the influence of apnea on aortic blood pressure and augmentation index (AIx), which cardiac load and independent risks for a future CVD event, remains unclear. Therefore, this study aimed to examine the influence of intermittent normoxic apnea on aortic arterial hemodynamics in healthy men. Methods: Sixteen healthy young men (23 ± 1.6 years mean ± SD) underwent the repetitive 20-s apnea with a 40 s interval for 20 min. During the interval, each subject maintained a breath pace at 15 breaths/min. Central hemodynamics were evaluated every 5 min by pulse wave analysis from peripheral (radial) arterial pressure waveforms via general transfer function method and compared among three phases defined as “breath” (for 20 s before apnea), “apnea”, and “rebreathe” (for 20 s after apnea). The baseline values were calculated from the first breathing cycle and compared with each breathing phase every 5 min. Results: Aortic systolic blood pressure and AIx were significantly higher at rebreathe phase than the other phases. Likewise, heart rate and double product (aortic systolic blood pressure × heart rate) were significantly higher in rebreathe phase than the other phases. Conclusions: These results suggest that cardiac load is increased by intermittent normoxic apnea, especially during the rebreathing phase.
Promising sequels of a novel nanoformulation of khamira abresham hakim Arshadwala against isoprenaline challenged cardiac damage in rodents

Background: Khamira Abresham Hakim Arshadwala (KAHAW), a distinguished, traditional Unani formulation comprising constituents of herbal, animal, and mineral origin, holds salubrious cardioprotective potential and has been used for cardiac ailments in the Unani system for ages. KAHAW is a ‘sugar-based’ preparation, which hinders its ‘claim to fame’ amongst cardiac patients with diabetes. Hence, it is fascinating to develop a novel nanoformulation of the traditional one and screen its efficacy experimentally on the male Wistar rats (4-week-old) (150-180gm). The objective was to revolutionize this historic gem of a formulation and enhance its therapeutic efficacy, a novel nanoformulation of KAHAW was developed, and its cardioprotective potential screened against isoprenaline (ISO) induced cardiotoxicity in rodents. The results were analyzed with the traditional formulations and two clinically used drugs, Ramipril and Carvedilol. Methods: Various parameters viz; Physical, Enzymatic, Non-enzymatic, and cardiac-specific biomarkers like α/β-MHC expression (Western Blot), Flow cytometry, Cardiac collagen content, and Mitochondrial enzyme assay were assessed on plasma, blood, and tissue samples followed by histomorphological investigations. Results: The effect of nanoformulation showed highly significant results (***p<0.001) when compared to disease control for different parameters viz, Total protein, GPx and GSH, Lipid peroxidation, and Vitamin E. The cardiac-specific biomarkers like α/β-MHC Expression (Western Blot), Flow Cytometry, Cardiac collagen content, and Mitochondrial enzyme assay also advocated the highly significant (***p<0.001) cardioprotective activity of the developed nanoformulation. Conclusions: The research reiterates that the novel nanoformulation offers improved efficacy at a reduced dose against ISO-induced experimental models of myocardial necrosis.
Effect of fillers on compression loading performance of modified re-entrant honeycomb auxetic sandwich structures

The auxetic sandwich panels for structures have been designed to provide impact protection. The aim of this work is to modify an auxetic (re-entrant) honeycomb cell to reduce the stress concentrations within the cell structure, and further enhancement of this design. The auxetic structure was filled to achieve a greater energy absorbance and enhance safety applications. Analytical and elastic three-dimensional finite element approaches were used to investigate the structural strength performance. The basic model (i.e. modified re-entrant strut cell design) consisted of the honeycomb auxetic polypropylene (PP) structure sandwiched between two steel plates (known as safety panels) which were placed under static compression loading. The cell geometry and size were then modified to reduce the stress concentration zones. The structure cells were filled with silly putty and polyvinyl chloride (PVC) foam. The effect of the filling the cells on the stress concentration and energy absorbance were analysed using elastic stress and deformation analysis methods. During the stress path analysis, it was found that an increase in Young’s modulus of the filling was directly proportional to a decrease in internal stresses. It was concluded that while filling the basic model with soft materials reduced the stress concentration, but it led to a reduction in the energy absorbance capability. Further on, the lower stress produced by the enhanced could be useful to prevent significant penetration of the protective panel. Compared to similar structures of steel, auxetic foam panels have the advantage of having only a fraction of the weight and being corrosion resistant at the same time as keeping impact strength. Graphical abstract
Polymerase Chain Reaction Study of Human Bocavirus in Children with Acute Gastroenteritis

The present study aimed to detect Human bocavirus (HBoV) in stool samples from young children below 5 years complaining of acute gastroenteritis (GE) in addition to detection of rotavirus, norovirus, and astrovirus. The study included 90 children below 5 years with acute GE with excluded bacterial pathogens. The determination of the presence of HBoV was performed by nested polymerase chain reaction (PCR) beside determination of astrovirus and norovirus by multiplex PCR and rotavirus antigen by enzyme-linked immunosorbent assay (ELISA). The most prevalent virus among the studied viruses was rotavirus (33.3%) detected by ELISA for antigen in the stool. The other three viruses detected by molecular methods were bocavirus (14.4%), astrovirus (13.3%), and norovirus (10%). Mixed viral infection with two or more viruses was detected in 16 children (17.8%). The most common was bocavirus and rotavirus in 6 patients (37.5%). In the study of demographic and clinical presentations of the children with HBoV, the affected children were mainly females, i.e., 10 (76.9%), from rural residence i.e., 11 (84.6%) with the mild classification of GE in 7 children (53.8%) and moderate GE in 6 children (46.2%) and none of them had severe GE. Fever was the most common presenting sign in those children (53.8%) followed by vomiting (46.2%). The study highlights the existence of HBoV in children with acute GE under the age of five. The infection associated with this virus was either mild or moderate in severity. The combined viral infection was common especially associated with rotavirus. There is a need for further additional study to identify the type of the circulated strain of bocavirus and the confections with other pathogens.
Foam Synthesis of Nickel/Nickel (II) Hydroxide Nanoflakes Using Double Templates of Surfactant Liquid Crystal and Hydrogen Bubbles: A High-Performance Catalyst for Methanol Electrooxidation in Alkaline Solution

This work demonstrates the chemical synthesis of two-dimensional nanoflakes of mesoporous nickel/nickel (II) hydroxide (Ni/Ni(OH)2-NFs) using double templates of surfactant self-assembled thin-film and foam of hydrogen bubbles produced by sodium borohydride reducing agent. Physicochemical characterizations show the formation of amorphous mesoporous 2D nanoflakes with a Ni/Ni(OH)2 structure and a high specific surface area (165 m2/g). Electrochemical studies show that the electrocatalytic activity of Ni/Ni(OH)2 nanoflakes towards methanol oxidation in alkaline solution is significantly enhanced in comparison with that of parent bare-Ni(OH)2 deposited from surfactant-free solution. Cyclic voltammetry shows that the methanol oxidation mass activity of Ni/Ni(OH)2-NFs reaches 545 A/cm2 gcat at 0.6 V vs. Ag/AgCl, which is more than five times higher than that of bare-Ni(OH)2. Moreover, Ni/Ni(OH)2-NFs reveal less charge transfer resistance (10.4 Ω), stable oxidation current density (625 A/cm2 gcat at 0.7 V vs. Ag/AgCl), and resistance to the adsorption of reaction intermediates and products during three hours of constant-potential methanol oxidation electrolysis in alkaline solution. The high-performance electrocatalytic activity of Ni/Ni(OH)2 nanoflakes is mainly derived from efficient charge transfer due to the high specific surface area of the 2D mesoporous architecture of the nanoflakes, as well as the mass transport of methanol to Ni2+/Ni3+ active sites throughout the catalyst layer.
Strong Coupling between a Single Quantum Emitter and a Plasmonic Nanoantenna on a Metallic Film

The strong coupling between single quantum emitters and resonant optical micro/nanocavities is beneficial for understanding light and matter interactions. Here, we propose a plasmonic nanoantenna placed on a metal film to achieve an ultra-high electric field enhancement in the nanogap and an ultra-small optical mode volume. The strong coupling between a single quantum dot (QD) and the designed structure is investigated in detail by both numerical simulations and theoretical calculations. When a single QD is inserted into the nanogap of the silver nanoantenna, the scattering spectra show a remarkably large splitting and anticrossing behavior of the vacuum Rabi splitting, which can be achieved in the scattering spectra by optimizing the nanoantenna thickness. Our work shows another way to enhance the light/matter interaction at a single quantum emitter limit, which can be useful for many nanophotonic and quantum applications.
Composition of Structural Behavior Factors in Codes of China,Japan,Europe and USA for Earthquake-Resistance and Their Corresponding Ductility Demands

The composition of structural performance factors for base shear determination in the codes of China, Japan, Europe and USA for earthquake-resistance are discussed. In USA, it includes overstrength factors of both the material and the structural system and the ductility, in EC8 it contains the ductility factor,and the structural overstrength factor in structural system with high ductility. In Japan and China, it reflects only the ductility. Because in Japan a load factor of 1.4 is introduced, it has the biggest earthquake forces for structural design. Based on the composition of the structural behavior factors, it can be deduced that the USA code puts the most severe demand on the plastic deformation capacity of structural members against earthquakes, Eurocode 8 lies on the second, and the Chinese code is on the third. The Japan code may have the least demand on the ductility although it contains similar requirements on detailing of members and joints.
Optimal operation model for wind-powered pumped storage system

Three feasible schemes for operation of wind-powered pumped storage system were proposed as follows: all of wind power was supplied to pumped storage plants for water pumping;part of wind power was directly transported to grid,while the rest was supplied to pumped storage plants for water pumping based on the capacity of grid and output of wind farm;all of wind power was directly transported to grid.An optimal operation model for wind-powered pumped storage system was established.With the model,the minimum capacity for conventional power plants in normal operation and the installed capacity for pumped storage plants needed in grid with certain amount of wind power were calculated,and an economic evaluation model was developed.Based on the evaluated result,the optimal operation scheme for wind-powered pumped storage system was selected.
A Simple Adiabatic Model for Vertical Variation of Halocline Slope in the Beaufort Gyre

The Beaufort Gyre is a large wind-driven circulation in the Canada Basin of the Western Arctic Ocean between approximately 120◦ − 180◦ W and 70◦ − 85◦ N. Figure 1 shows the bathymetry and spatial pattern of salinity at 200 m in the Beaufort Gyre. The gyre is a persistent feature in the upper ∼300 m of the ocean, driven primarily by the climatological anticyclonic winds associated with the wintertime Beaufort High sea level pressure system. The winds cause Ekman downwelling, which pumps low-salinity surface water into the gyre interior, deepens the halocline, and sets up the resulting anticyclonic circulation. Although the climatological mean winds are anticyclonic, there is considerable seasonal variability; the winds are strongly anticyclonic during the winter and weakest (potentially even cyclonic) during the summer. Nevertheless, the upper-ocean circulation is persistently anticyclonic due to the bowl-shaped deformation of the isopycnals associated with the freshwater storage [9]. The surface waters of the Arctic are relatively fresh due to the excess of precipitation over evaporation in the basin and due to its drainage of numerous large river systems and low-salinity Pacific inflow. The freshwater content (m) is defined as
Evaluation of 6-Hydroxydopamine and Rotenone In Vitro Neurotoxicity on Differentiated SH-SY5Y Cells Using Applied Computational Statistics

With the increase in life expectancy and consequent aging of the world’s population, the prevalence of many neurodegenerative diseases is increasing, without concomitant improvement in diagnostics and therapeutics. These diseases share neuropathological hallmarks, including mitochondrial dysfunction. In fact, as mitochondrial alterations appear prior to neuronal cell death at an early phase of a disease’s onset, the study and modulation of mitochondrial alterations have emerged as promising strategies to predict and prevent neurotoxicity and neuronal cell death before the onset of cell viability alterations. In this work, differentiated SH-SY5Y cells were treated with the mitochondrial-targeted neurotoxicants 6-hydroxydopamine and rotenone. These compounds were used at different concentrations and for different time points to understand the similarities and differences in their mechanisms of action. To accomplish this, data on mitochondrial parameters were acquired and analyzed using unsupervised (hierarchical clustering) and supervised (decision tree) machine learning methods. Both biochemical and computational analyses resulted in an evident distinction between the neurotoxic effects of 6-hydroxydopamine and rotenone, specifically for the highest concentrations of both compounds.
A destabilizer of both Wnt/β-catenin and Ras/ERK pathways suppresses cancer stem cell activation in colorectal cancer

Cancer stem cells (CSCs) are a tumor cell subpopulation that drives tumor progression and metastasis, leading to poor overall survival of patients. In colorectal cancer (CRC), hyper-activation of Wnt/β-catenin signaling by mutation of both Adenomatous polyposis coli (APC) and K-Ras increases the size of the CSC population. We previously showed that the CPD0857 inactivates Wnt/β-catenin signaling by promoting ubiquitin-dependent proteasomal degradation of β-catenin and Ras proteins, thereby decreasing proliferation and increasing apoptosis of CRC lines. CPD0857 also decreased growth and invasiveness of CRC cells harboring mutant K-Ras resistant to EGFR mAb therapy. Here, we show that CPD0857 treatment decreases proliferation and increases neuronal differentiation of neural progenitor cells (NPCs). CDP0857 effectively reduced expression of CSC markers and suppressed self-renewal capacity. CPD0857 treatment also inhibited proliferation and expression of CSC markers in D-K-Ras MT cells carrying K-Ras, APC and PI3K mutations, indicating inhibition of PI3K/AKT signaling. Moreover, CPD0857-treated xenograft mice showed regression of tumor growth and decreased numbers of CSCs in tumors. We conclude that CPD0857 could serve as the basis of a drug development strategy targeting CSCs activated through Wnt/β-catenin-Ras MAPK-PI3K/AKT signaling in CRCs.
Response to Russell Scott ( Referee # 1 )

In this paper, the authors examine the transpiration of a grazed savanna in Africa to determine what are the controls on annual ET partitioning. They do this by using 6 yrs of eddy covariance data and three different partitioning techniques. They conclude that early season rainfall timing strongly controlled annual T/ET by affecting the growing season dynamics primarily of grasses rather than the trees.
Metal-poor Stars Observed with the Southern African Large Telescope II. An Extended Sample

We present results from high-resolution (R ∼ 40,000) spectroscopic observations of over 200 metal-poor stars, mostly selected from the RAVE survey, using the Southern African Large Telescope. We were able to derive stellar parameters for a total of 108 stars; an additional sample of 50 stars from this same effort was previously reported on by Rasmussen et al. Among our newly reported observations, we identify 84 very metal-poor (VMP; [Fe/H] < −2.0, 53 newly identified) stars and three extremely metal-poor (EMP; [Fe/H] < −3.0, one newly identified) stars. The elemental abundances were measured for carbon, as well as several other α-elements (Mg, Ca, Sc, and Ti), iron-peak elements (Mn, Co, Ni, and Zn), and neutron-capture elements (Sr, Ba, and Eu). Based on these measurements, the stars are classified by their carbon and neutron-capture abundances into carbon-enhanced metal-poor (CEMP; [C/Fe] > +0.70), CEMP subclasses, and by the level of their r-process abundances. A total of 17 are classified as CEMP stars. There are 11 CEMP-r stars (eight newly identified), one CEMP-s star (newly identified), two possible CEMP-i stars (one newly identified), and three CEMP-no stars (all newly identified) in this work. We found 11 stars (eight newly identified) that are strongly enhanced in r-process elements (r-II; [Eu/Fe] > +0.70), 38 stars (31 newly identified) that are moderately enhanced in r-process elements (r-I; +0.30 < [Eu/Fe] ≤ + 0.70), and one newly identified limited-r star.