Miracle-dz/UniFAR-FTUs huggingface dataset:
HealthTree Cure Hub: A Patient-Derived, Patient-Driven Clinical Cancer Information Platform Used to Overcome Hurdles and Accelerate Research in Multiple Myeloma

PURPOSE The study of rare diseases, such as multiple myeloma (MM), often experiences unique research hurdles that can delay or prevent lifesaving discoveries. HealthTree Cure Hub is a first-in-class software program designed to overcome these potential research hurdles. METHODS We assessed whether HealthTree Cure Hub improved four commonly experienced research hurdles such as (1) small numbers of patient accrual to clinical trials and research studies, (2) shallow and isolated data sets, (3) high costs to answer research questions, and (4) lack of long-term follow-up patient data. RESULTS As of June 2021, HealthTree Cure Hub, with its unique portal features, has attracted 9,225 patients with MM and diverse demographic backgrounds. While completing an online health profile, patients shared comprehensive data, as well as provided consent to contribute data from electronic medical records. Portal use answered research questions using patient-driven real-world data. This also cultivated relationships with patients and established communication channels that enabled continual patient contact to allow for long-term follow-up. CONCLUSION These results suggest that a patient-driven data capture tool such as HealthTree Cure Hub will help alleviate common research hurdles, which, in turn, will accelerate MM research, develop new hypotheses, and ultimately improve survival. Changing RWE research with the most complete and valid MM patient data set. 10k+ patients in HealthTree. #MultipleMyeloma #RealWorldData
Priming Cardiac Function with Voluntary Respiratory Maneuvers and Effect on Early Exercise Oxygen Uptake.

Oxygen uptake (V'O2) at exercise onset is determined in part by acceleration of pulmonary blood flow (Q'p). Impairments in the Q'p response can decrease exercise tolerance. Prior research has shown that voluntary respiratory maneuvers can augment venous return, but the corollary impacts on cardiac function, Q'p and early-exercise V'O2 remain uncertain. We examined a) the cardiovascular effects of 3 distinct respiratory maneuvers (abdominal, AB; rib cage, RC and deep breathing, DB) under resting conditions in healthy subjects (Protocol 1, n=13) and b) the impact of pre-exercise DB on pulmonary O2 transfer during initiation of moderate intensity exercise (Protocol 2, n=8). In Protocol 1, echocardiographic analysis showed increased RV and LV cardiac output (RVCO and LVCO, respectively) following AB (by +23±13 and +18±15%, respectively, P<0.05), RC (+23±16; +14±15%, P<0.05) and DB (+27±21; +23±14%, P<0.05). In Protocol 2, DB performed for 12 breaths produced a pre-exercise increase in V'O2 (+801±254 ml·min-1 over ~ 6 s), presumably from increased Q'p followed by a reduction in pulmonary O2 transfer during early phase exercise (first 20 s) compared to the control condition (149±51 vs 233±65 ml, P<0.05). We conclude that (1) respiratory maneuvers enhance RVCO and LVCO in healthy subjects under resting conditions, (2) AB, RC and DB have similar effects on RVCO and LVCO, and (3) DB can increase Q'p prior to exercise onset. These findings suggest that pre-exercise respiratory maneuvers may represent a promising strategy to prime V'O2 kinetics and thereby to potentially improve exercise tolerance in patients with impaired cardiac function.
Deubiquitinase ubiquitin‐specific peptidase 10 maintains cysteine rich angiogenic inducer 61 expression via Yes1 associated transcriptional regulator to augment immune escape and metastasis of pancreatic adenocarcinoma

Pancreatic adenocarcinoma (PAAD) remains an extremely fatal malignancy with a high mortality rate worldwide. This study focuses on the roles of ubiquitin‐specific peptidase 10 (USP10) and cysteine rich angiogenic inducer 61 (Cyr61) in macrophage polarization, immune escape, and metastasis of PAAD. USP10 showed a positive correlation with Yes1 associated transcriptional regulator (YAP1), which, according to the TCGA‐PAAD database, is highly expressed in PAAD and indicates poor patient prognosis. USP10 knockdown increased ubiquitination and degradation of YAP1, which further decreased the programmed cell death ligand 1 (PD‐L1) and Galectin‐9 expression, suppressed immune escape, and reduced the proliferation and metastasis of PAAD cells in vitro and in vivo. Cyr61, a downstream factor of YAP1, was overexpressed in PAAD cells after USP10 silencing for rescue experiments. Overexpression of Cyr61 restored the PD‐L1 and Galectin‐9 expression in cells and triggered M2 polarization of macrophages, which enhanced the immune escape and maintained the proliferation and metastasis ability of PAAD cells. In conclusion, this work demonstrates that USP10 inhibits YAP1 ubiquitination and degradation to promote Cyr61 expression, which induces immune escape and promotes growth and metastasis of PAAD.
Ultrasound-assisted modification of gelation properties of proteins- a review.

Protein gels have diverse applications in the food, pharmaceutical, and cosmetic sector due to their affordability, biodegradability, and edibility. However, the inherent properties of some native proteins have a few drawbacks that have to be tailored to meet the needs of specific functions as the food ingredients. The protein gelation properties mainly depend on the protein molecular structure, primarily the folding and unfolding of secondary structural elements (α-helix and β-sheets) with distinctive functions. In the past, a great amount of work (thermal, chemical, and enzymatic methods) has been carried out to enhance the gelation and functional properties of proteins. Recently, the traditional methods have been replaced with non-thermal physical methods that enhance the properties for better applications. One such approach is the use of Ultrasonic technology as a low-cost green technology to modify the molecular orientation attributed to the native chemistry and functionality of that proteins. Ultrasonic technology is important in food systems and can be effectively used as an alternative method to improve the protein gelling characteristics to form high-quality gels. This article is aimed to comprehensively collate some of the vital information published on the mechanism of protein gelation by ultrasonication and review the effects of ultrasound-assisted extraction and treatments on gelation properties of different proteins. The enhanced gelation properties by the ultrasound application open a new stage of technology that enables the proteins for better utilization in the food processing sector. This article is protected by copyright. All rights reserved.
Effects of rosuvastatin combined with clopidogrel bisulfate on blood lipids, cardiac function and inflammatory factor levels in elderly patients with coronary heart disease.

OBJECTIVE To investigate the effects of rosuvastatin combined with clopidogrel bisulfate on blood lipids, cardiac function, and inflammatory factor levels in elderly patients with coronary heart disease (CHD). METHODS A total of 100 elderly patients with CHD treated in our hospital from January 2018 to January 2020 were retrospectively selected and assigned to the control group (n=50) and the observation group (n=50) according to different types of medications. The control group was treated with clopidogrel bisulfate, while the observation group was treated with clopidogrel bisulfate combined with rosuvastatin. T1, T2, T3, and T4, which indicated 5, 10, 15, and 20 days after medication respectively, were set up to observe the changes of relevant indexes in the two groups after medication. The changes in blood lipids, cardiac function, and inflammatory factors were compared between the two groups. RESULTS The clinical efficacy of the observation group was superior to the control group (P<0.05). No significant differences were determined in the levels of TC and LDL-C at T1 and T2 between the two groups (P>0.05); however, the observation group obtained lower TC and LDL-C levels than the control group at T3 and T4 (P<0.05). The levels of hs-CRP, TNF-α, BNP and NT-proBNP were not significantly different between the two groups at T1 and T2 (P>0.05), and lower levels of hs-CRP, TNF-α, BNP and NT-proBNP were observed in the observation group than in the control group at T3 and T4 (P<0.05). The two groups presented no significant differences in the left ventricular ejection fraction (LVEF) level and the Wall Motion Score Index (WMSI) score (P>0.05). After treatment, the observation group scored higher in the LVEF level and lower in the WMSI score than the control group (both P<0.05). The adverse reaction rate of the two groups was similar (P>0.05). CONCLUSION Rosuvastatin combined with clopidogrel bisulfate is effective in the treatment of elderly patients with CHD, which can effectively improve the cardiac function of patients and reduce the levels of blood lipids and inflammatory factors.
Factores determinantes de la externalización del proceso de recepción, fabricación y distribución desde la perspectiva de los recursos y relacional

The purpose of this study is to examine the factors influencing the decision to outsource the process of receipt, manufacture and delivery of orders. Most research into outsourcing decisions and their determinants has been performed from the view of the transactions costs theory, mainly by analyzing specificity as the most important factor at the time of taking the outsourcing decision. In this respect, and in an attempt to fill this gap in the literature, this work analyzes the outsourcing process from the relational and resource-based view Therefore, and from these perspectives, other variables that may explain the decision to outsource have been taken as a reference. These va- riables include the core competences, relational capabilities and the competitiveness or performance of the activity. This work also contains an analysis of the relationship between the outsourcing process and both the geographical area and the turnover . The results reflect that the operation performance and the possibility of establishing relational capabilities are the factors that most influence the outsourcing of the process under study, rather than the fact that the operation may be valuable or generate core competences for the firm. It is also shown that the geographical area and the turnover both have a positive relationship with the outsourcing of the process of reception, manufactu- re and distribution of orders.
Age‐specificity and generalization of behavior‐associated structural and functional networks and their relevance to behavioral domains

Behavior‐associated structural connectivity (SC) and resting‐state functional connectivity (rsFC) networks undergo various changes in aging. To study these changes, we proposed a continuous dimension where at one end networks generalize well across age groups in terms of behavioral predictions (age‐general) and at the other end, they predict behaviors well in a specific age group but fare poorly in another age group (age‐specific). We examined how age generalizability/specificity of multimodal behavioral associated brain networks varies across behavioral domains and imaging modalities. Prediction models consisting of SC and/or rsFC networks were trained to predict a diverse range of 75 behavioral outcomes in a young adult sample (N = 92). These models were then used to predict behavioral outcomes in unseen young (N = 60) and old (N = 60) subjects. As expected, behavioral prediction models derived from the young age group, produced more accurate predictions in the unseen young than old subjects. These behavioral predictions also differed significantly across behavioral domains, but not imaging modalities. Networks associated with cognitive functions, except for a few mostly relating to semantic knowledge, fell toward the age‐specific end of the spectrum (i.e., poor young‐to‐old generalizability). These findings suggest behavior‐associated brain networks are malleable to different degrees in aging; such malleability is partly determined by the nature of the behavior.
Evaluation of correlation between CD44, radiotherapy response, and survival rate in patients with advanced stage of head and neck squamous cell carcinoma (HNSCC)

Cancer stem cells (CSCs) constitute a distinctive subpopulation of cancer cells that are competent in tumor initiation, invasion, recurrence, and resistance to chemoradiotherapy. CD44, a hyaluronic acid (HA) receptor has been considered as a potential CSC marker in head and neck cancer. The purpose of this study is to evaluate the correlation between CD44 and clinicopathological parameters, treatment response, survival, and recurrence.
An integrated DEMATEL–ANP approach for identification and prioritization of factors affecting fall from height accidents in the construction industry

ABSTRACT Objectives. The decision-making trial and evaluation laboratory (DEMATEL) technique integrated with the analytic network process (ANP) is used for determination and prioritization of cause–effect relationships among factors affecting construction falls. Methods. Considering the 135 fall accidents collected between 2013 and 2018 from 15 residential construction projects, 70 factors and sub-factors affecting the occurrence of construction falls were determined based on safety experts’ opinions. Questionnaires based on the former and the latter were then distributed among 10 occupational health and safety specialists to determine the effectiveness of the factors. The interactions and important degree of each factor are specified, using the DEMATEL–ANP approach. Results. Findings showed that organizational factors and their sub-factors have the greatest impact on construction falls and were considered as causal variables ( D – R > 0), while individual and environmental factors were considered as the effect variables ( D – R < 0). The results of prioritization using the ANP method showed that the work platform altitude, psychological/occupational stresses and interactions were ranked as the first through third priorities affecting the falls, respectively. Conclusions. It is necessary to implement a systematic strategy to reduce the unsafe conditions in construction projects and to pay more attention to organizational factors.
Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies

Background: Alpha-synucleinopathies (AS) are characterized by pathologic aggregations of alpha-synuclein (α-syn) in the central nervous system, and comprise dementia with Lewy bodies, Parkinson’s disease, and multiple system atrophy. Previous studies on AS have reported findings of α-syn pathology in the peripheral nervous system of multiple organs, including the heart. Objective: The aim of this study was to further investigate and confirm the presence of cardiac α-syn in AS compared to other major neurocognitive disorders in a neuropathologically confirmed cohort. Methods: All deceased patients with performed autopsy and with neuropathologically confirmed AS at the Clinical Department of Pathology in Lund 2010–May 2021 were evaluated for inclusion. Cases with insufficiently sampled cardiac tissue or only limited neuropathological investigation were excluded. An age-matched group of individuals with other neurodegenerative diseases, having no α-syn in the CNS, served as controls. In total, 68 AS and 32 control cases were included in the study. Immunohistochemistry for detection of cardiac α-syn aggregates was performed. Results: The AS group had a significantly higher prevalence of cardiac α-syn pathology (p≤0.001) than the control group, 82% and 0%, respectively. Conclusion: This study confirms the association between AS and the presence of cardiac α-syn in a neuropathologically confirmed cohort. This motivates further research on potential pathophysiological effects on cardiac function in AS patients.
Recent Developments in Upscalable Printing Techniques for Perovskite Solar Cells

Just over a decade, perovskite solar cells (PSCs) have been emerged as a next‐generation photovoltaic technology due to their skyrocketing power conversion efficiency (PCE), low cost, and easy manufacturing techniques compared to Si solar cells. Several methods and procedures have been developed to fabricate high‐quality perovskite films to improve the scalability and commercialize PSCs. Recently, several printing technologies such as blade‐coating, slot‐die coating, spray coating, flexographic printing, gravure printing, screen printing, and inkjet printing have been found to be very effective in controlling film formation and improving the PCE of over 21%. This review summarizes the intensive research efforts given for these printing techniques to scale up the perovskite films as well as the hole transport layer (HTL), the electron transport layer (ETL), and electrodes for PSCs. In the end, this review presents a description of the future research scope to overcome the challenges being faced in the printing techniques for the commercialization of PSCs.
Long noncoding RNA polymorphisms and colorectal cancer risk: Progression and future perspectives

Colorectal cancer (CRC) is one of the most common cancers causing death worldwide. Many long noncoding RNAs (lncRNAs) have possible carcinogenic or tumor suppressor functions. Some lncRNA polymorphisms are useful for predicting cancer risk, and may help advance personalized therapy management. While the use of lncRNAs as biomarkers is promising, there are still drawbacks, and further studies are needed to verify the consistency of current outcomes in large‐scale populations and different ethnicities. Single nucleotide polymorphisms (SNPs) can disrupt a lncRNAs' function, thus enhancing or hindering disease occurrence. SNPs can directly influence the lncRNA expression by interfering with transcription factor binding or affecting indirectly a regulatory factors' expression. Moreover, the association between lncRNAs and other RNAs or proteins may be disrupted by SNPs. This research sought to assess the association between lncRNA polymorphisms and CRC risk, as well as clinical and therapeutic consequences in certain cases.
Peritumoral matrilin‐2 staining may be useful in distinguishing basal cell carcinoma from folliculocentric basaloid proliferation

Folliculocentric basaloid proliferation (FBP) is a benign and reactive proliferation which can histopathologically mimic basal cell carcinomas (BCCs). The incidental presence of FBP during the excision of a BCC can occasionally lead to excessive tissue removal. One distinguishing feature of BCCs is that they invade the stroma, whereas FBPs generally do not.
Effects of Electroencephalogram Biofeedback on Emotion Regulation and Brain Homeostasis of Late Adolescents in the COVID-19 Pandemic.

PURPOSE The purpose of this study was to examine the effects of electroencephalogram (EEG) biofeedback training for emotion regulation and brain homeostasis on anxiety about COVID-19 infection, impulsivity, anger rumination, meta-mood, and self-regulation ability of late adolescents in the prolonged COVID-19 pandemic situation. METHODS A non-equivalent control group pretest-posttest design was used. The participants included 55 late adolescents in the experimental and control groups. The variables were evaluated using quantitative EEG at pre-post time points in the experimental group. The experimental groups received 10 sessions using the three-band protocol for five weeks. The collected data were analyzed using the Shapiro-Wilk test, Wilcoxon rank sum test, Wilcoxon signed-rank test, t-test and paired t-test using the SAS 9.3 program. The collected EEG data used a frequency series power spectrum analysis method through fast Fourier transform. RESULTS Significant differences in emotion regulation between the two groups were observed in the anxiety about COVID-19 infection (W = 585.50, p = .002), mood repair of meta-mood (W = 889.50, p = .024), self-regulation ability (t = -5.02, p < .001), self-regulation mode (t = -4.74, p < .001), and volitional inhibition mode (t = -2.61, p = .012). Neurofeedback training for brain homeostasis was effected on enhanced sensory-motor rhythm (S = 177.00, p < .001) and inhibited theta (S = -166.00, p < .001). CONCLUSION The results demonstrate the potential of EEG biofeedback training as an independent nursing intervention that can markedly improve anxiety, mood-repair, and self-regulation ability for emotional distress during the COVID-19 pandemic.
Interaction of Anagrelide drug molecule on pristine and doped boron nitride nanocages: a DFT, RDG, PCM and QTAIM investigation

Abstract Nowadays, a nanostructure-based drug delivery system is one of the most noticeable topics to be studied, and in this regard, boron nitride nanoclusters are promising drug carriers for targeted drug delivery systems. In this article, the interaction mechanism of Anagrelide (AG) drug with B12N12 and Al- and Ga-doped B12N12 nanocages have been investigated using DFT with B3LYP/6-31 G (d, p) method in both gas and water media. All our studied complexes are thermodynamically stable, and doped nanocage complexes have higher negative adsorption energy (EAd.) and negative solvation energy than AG/B12N12 complexes which correspond to the stability of these systems in both media. The negative highest EAd value is 64.98 kcal/mol (63.17 kcal/mol) and 65.69 kcal/mol (65.11 kcal/mol) in gas (water) media for complex F (AG/AlB11N12) and complex I (AG/GaB11N12) respectively, which refers to the highest stability of these systems. The enhanced values of dipole moment (from 12.40 (12.65) Debye to 17.21 (17.69) Debye in complex F (complex I)) also confirm their stability. The QTAIM and RDG analysis endorse the strong adsorption nature of the AG drug onto the AlB11N12, and GaB11N12 nanocages, which is consistent with the adsorption energy as chemisorption occurs for these complexes. According to the electronic properties, doped nanocages show high sensitivity that infers their promising nature for drug delivery purposes. Thus, complex F and complex I are promising drug delivery systems, and doped nanocages (AlB11N12 and GaB11N12) are better carriers than pristine nanocages for the AG drug delivery system. Communicated by Ramaswamy H. Sarma