Miracle-dz/UniFAR-FTUs huggingface dataset:
OPTH_A_266218 3219..3226

1Department of Cornea, Tilganga Institute of Ophthalmology, Kathmandu, Nepal; 2Department of Microbiology, Tilganga Institute of Ophthalmology, Kathmandu, Nepal Background: Infective keratitis is the most common corneal pathology in developing countries. Updated knowledge is needed for its control and proper management. Methodology: All cases of presumed microbial keratitis that presented in an 18-month period from October 2013 to March 2015 were enrolled. Data collected were demographic profile, risk factors, clinical features, and organisms isolated and their sensitivities. Results: A total of 602 cases of microbial keratitis were enrolled. Mean age of subjects (598 patients) was 47.9 years with 53.8% male. 64.1% worked in agriculture. 38.3% gave history of trauma followed by history of herpetic eye diseases (17.9%) and topical steroid use (14.2%). A total of 473 who were referred came at an average of 21.5 days of symptoms. 14.9% (n=90) of cases were either perforated or impending to perforate at presentation. 69.6% had infiltrate in the visual axis. A total of 516 (85.7%) underwent diagnostic corneal culture. A total of 256 (49.6%) yielded a positive result. Pure bacterial growth was seen in 111 (43.4%), pure fungal growth in 138 (53.9%), and mixed microbial growth was present in 7 (2.7%) cases. Out of 121 bacterial isolates, 95.0% were Gram positive. Streptococcus pneumoniae (45.5%, n=55) was the most common bacterial isolate followed by Staphylococcus aureus (20.6%, n=25). Out of 145 fungal isolates, Aspergillus and Fusarium species were found in equal numbers (n=41, 28.3% each). Over 85% of Grampositive organisms isolated in the study were sensitive to vancomycin, cefazolin, moxifloxacin, and gatifloxacin. Over 80% of Gram-negative organisms were sensitive to gentamicin, tobramycin, and amikacin. Conclusion: Microbial keratitis and associated risk factors occurring in farmers implies a lack of awareness and prevention programs. Delay in reaching tertiary care is resulting in complicated cases. Training of local health workers for prophylaxis, updated guidelines for treating keratitis, and timely referral to higher centers are all important in a chain to decrease the incidence of microbial keratitis.
Exploring Workplace Testing with Real-Time Polymerase Chain Reaction SARS-CoV-2 Testing

Background: Molecular tests (ie, real-time polymerase chain reaction [RT-PCR]) and antigen tests are used to detect SARS-CoV-2. RT-PCR tests are generally considered to be the standard for clinical diagnosis of SARS-CoV-2 due to accuracy and reliability but can take longer to return results than antigen tests. Our aim was to examine if point-of-care (POC) testing for SARS-CoV-2 infection would provide a ﬂexible resource to help achieve workplace safety. We compared test results and time-to-test results between a POC RT-PCR test and a send-out PCR test in a program implemented in summer 2020. Results: POC testing shortened the time to results to 110 minutes in the POC setting from the 754 minutes for send-out tests. The speciﬁcity of POC RT-PCR single POC testing was 98.7% compared with send-out RT-PCR testing and was conﬁrmed at 99.8% in a validation analysis. The sensitivity of the POC testing was 100% compared with send-out RT-PCR, although in a validation analysis, sensitivity appeared as 0% because only the 12 positive or indeterminate samples on the ﬁrst analysis were retested and the majority were false-positives that were correctly ruled out. Conclusions: POC testing for SARS-CoV-2 with RT-PCR technology is possible at reduced time compared with send-out PCR testing. ( J Am Board Fam Med 2022;35:96–101.)
EMERGING TRENDS IN SOCIAL MEDIA AND EMAIL BASED DATA LEAK PREVENTION (DLP) TECHNIQUES

: The field of research that is concerned with the study of threats to the security of organizational data and identifying strategies for prevention of these threats is known as Data Leak Prevention (DLP). The data leaks include releasing information that is sensitive to an untrustworthy third party which may either be intentional or not. At the same time, loss of data denotes the damage or disappearance of such data where the correct copy of data is not with the organization anymore. All of these will correspond to compromises made to the integrity and availability of data. The data leak or loss resulted in a major loss to revenue in the organisation that has been affected and also is a threat to its very existence. All the organizations that make use of electronic storage of data may become vulnerable to such attacks. The authors make an analysis of the threats to data and also the parties that are part of this threat, successful attack on the organization, social network and its impact and all the approaches to DLP used currently.The authors had further studied the model of the DLP through the analysis of the social network. So, the primary goal of the analysis of social network for the DLP was the identification of the patterns of communication in the organization, employing feedback from administrators for identifying any unusual communication for uncovering any data leaks.
Glargine prescribing practices for Type 2 diabetes: is there room for improvement?

Correspondence: Yvonne Elliott-Kemp Grad Dip Diabetes Education University of Queensland School of Nursing and Midwifery 45 Chisholm Road Carrara Gold Coast Queensland 4211 Australia Telephone: 0407425130 E-mail: yvonne_elliott-kemp@ health.qld. gov.au ELLIOTT-KEMP Y, AHERN K & OSTINI R (2011) Journal of Nursing and Healthcare of Chronic Illness 3, 352–360 Glargine prescribing practices for Type 2 diabetes: is there room for improvement? Aim. This study investigated Glargine prescribing practices at an outpatient clinic in a tertiary hospital. Background. Treatment outcomes for people with Type 2 diabetes have improved with the introduction of the basal insulin Glargine. However, to achieve optimal therapeutic results in a safe fashion, this insulin must be titrated in accordance with the manufacturer’s recommendation. Method. Medical records of patients with Type 2 diabetes who had attended an outpatient clinic between 2007–2008 were reviewed. Data collected included the age and gender of the patient, whether the patient’s insulin dose had been titrated, the Haemoglobin A1c (HbA1c) percentage on prescription of Glargine and followup HbA1c results and the time elapsed between the initial and follow-up HbA1c. Findings. Only 14AE6% of all patients had their Glargine insulin prescription adjusted according to the manufacturer’s recommendation. Despite this, prescription of Glargine insulin resulted in 43% of patients reducing their HbA1c result by at least 1%. Conclusion. Findings suggest that Glargine insulin was a contributing factor in the reduction of the patient’s HbA1c. Relevance to clinical practice. This study indicates that Glargine insulin is not consistently prescribed as per the manufacturer’s recommendation. Patient or clinician factors could explain why such a small percentage of patients had their Glargine prescription adjusted appropriately. Individualisation of Glargine insulin adjustment regimes, particularly in patients over the age of 75 years is vital to ensure positive patient outcomes.
The status of PD-L1 and tumor-in ﬁ ltrating immune cells predict resistance and poor prognosis in BRAFi-treated melanoma patients harboring mutant BRAF V600

Background: BRAF inhibitors (BRAFi) improve survival in metastatic melanoma patients (MMP) but the duration of clinical bene ﬁ t is limited by development of drug resistance. Here, we investigated whether the expression of programmed death-ligand 1 (PD-L1) and the density of tumor-in ﬁ ltrating mononuclear cells (TIMC) predict the occurrence of resistance, hence affecting the clinical outcome in BRAFi-treated MMP. Methods: PD-L1 expression (cutoff 5%) was analyzed by immunohistochemistry with two different antibodies in BRAF V600 -mutated formalin- ﬁ xed and paraf ﬁ n-embedded samples from 80 consecutive MMP treated with BRAFi at a single institution. TIMC were evaluated by conventional hematoxylin and eosin staining. Results: Forty-six and 34 patients received vemurafenib and dabrafenib, respectively. Membranous expression of PD-L1 was detected in 28/80 (35%) of patients. At multivariate analysis, absence of tumoral PD-L1 staining [odd ratio (OR) 10.8, 95% con ﬁ dence interval (CI) 2.7 – 43.3, P < 0.001] and the presence of TIMC (OR 6.5, 95% CI 1.7 – 24.3, P < 0.005) were associated with a better response to treatment. Median progression-free survival (PFS) and overall survival were 10 and 15 months, respectively. By multivariate assessment, PD-L1 expression [hazard ratio (HR) 4.3, 95% CI 2.1 – 8.7, P < 0.0001] and absence of TIMC (HR 2.5, 95% CI 1.4 – 4.7, P < 0.002) correlated with shorter PFS. PD-L1 overexpression (HR 6.2, 95% CI 2.8 – 14.2, P < 0.0001) and absence of TIMC (HR 3.1, 95% CI 1.5 – 6.5, P < 0.002) were independent prognostic factors for melanoma-speci ﬁ c survival. Conclusion: Our results provide the ﬁ rst proof-of-principle evidence for the predictive and prognostic relevance of PD-L1 immunohistochemical expression and density of immune cell in ﬁ ltration in BRAF V600 -mutated MMP treated with BRAFi. Background: The management of advanced neuroendocrine tumors (NETs) has recently changed. We assessed the activity of pazopanib after failure of other systemic treatments in advanced NETs. Methods: This was a multicenter, open-label, phase II study evaluating pazopanib as a single agent in advanced NETs (PAZONET study). The clinical bene ﬁ t rate (CBR) at 6 months was the primary end point. Translational correlation of
Reversible data hiding in encrypted images with RSA andElgamal algorithm

This paper puts forward reversible concealing plans for figure content pictures encoded by techniques for open key cryptosystems with probabilistic and homomorphic properties. Inside the reversible plan despite the fact that a direct contortion is presented, the inserted infor-mation might be separated, and the special picture might be recuperated from the immediately unscrambled photograph. With the combined strategy, a beneficiary may evacuate a bit of inserted data before unscrambling and expel some other piece of installed data and recuperate the genuine plaintext picture post-decoding. Here we propose to actualize the RSA and ElGamal consolidated calculation for picture encod-ing and decoding.
Mycorrhizae Aided Nitrogen Nutrition and Drought Tolerance in Plants

Mycorrhizas are known to improve host plant nutritional status as a consequence of water transport from the soil to the host plant through the external mycelium as a direct effect or improved host plant nutrition primarily, phosphorus as an indirect effect. The direct hyphal water transport is quantified to be meager and a major part of the benefits of mycorrhizal symbiosis is indirect and nutritionally related. In arid and semi-arid regions where drought occurrence is very frequent and soil moisture content is highly restricted, mycorrhizas can assist in exploiting the soil beyond the rhizosphere that helps the host plant to withstand drought stress conditions. The drought tolerance in mycorrhiza-inoculated plants is quite complex and such response is due to a series of processes such as improved nitrogen (N) availability in soils, extensive root surface area and cationic exchange capacity, collective N assimilatory pathways in plant-mycorrhizal system, luxuriant uptake of nutrients besides remobilization of nutrients to support grain growth. These physiological, biochemical, nutritional and morphological changes in the mycorrhizas associated host plants have contributed to the ability of the host plants to survive under limited water environments. Despite mycorrhiza-assisted and N nutritionally enabled host plant drought tolerance is evident, more research is required to gain insights into the mechanisms involved. This review highlights the role of mycorrhizas on N dynamics in the rhizosphere and enhanced host plant N nutrition that collectively contributes to the sustained crop productivity under drought stress conditions.
HISTOPATHOLOGICAL FINDINGS IN HYSTERECTOMIES DONE FOR ABNORMAL UTERINE BLEEDING

Background: Abnormal uterine bleeding is the bleeding from uterus, abnormal either in amount, duration,frequency, regularity or in its relation to menstruation in the absence of any palpable or detectable pelvic pathology. Hysterectomy is done in situations where medical management can no longer be used. The underlying pathology causing bleeding is categorised as per the FIGO PALM-COEIN guidelines. Material and Methods: The study was conducted at a tertiary care Hospital over a period of two and half years. During this period one hundred and six hysterectomies with clinical indication of abnormal uterine bleeding (AUB) were included in the study. The specimens were received in 10% formalin saline, macroscopic findings noted. Representative sections were taken. Tissue processed, paraffin blocks made, staining done, histopathology findings noted and data analyzed. Results: About 11.5% (106/915) of total hysterectomies were done with clinical indication of abnormal uterine bleeding. Patients’ age ranged from 28 to 58 years; mean 43.7 ± 6.4 years. On histopathological examination 64(60.4%) cases had identifiable cause of bleeding while it was not found in 42(39.6%) cases. Of the cases with identifiable causes abdominal approach was preferred in all 64(100%) cases; adnexae were removed in 52(81.2%) patients. Identifiable causes were adenomyosis in 31(48.4%), leiomyoma in 22(34.3%). About 19(29.6%) cases had dual pathology of leiomyoma and adenomyosis. If the leiomyoma was small or single then bleeding was attributed to adenomyosis. Polyp was seen in 5(7.8%). Other causes included were chronic endometritis in (6; 9.3%) and ovarian malignancy in 1 (1.5%) case. Conclusions: Patients with abnormal uterine bleeding should be thoroughly investigated for coagulation, ovulation and endometrial lesions as no histopathological lesion is detectable in these cases while with detectable lesion adenomyosis and leiomyoma were the most common non neoplastic and neoplastic lesions respectively.
SpaceCustomiser: InterActive

SpaceCustomiser is an ongoing research focusing on the development of digital methodologies and tools for designs based on non-Euclidean geometries. This paper describes SpaceCustomiser: InterActive, which deals with the development of digital design strategies based on non-Euclidean geometries, whereas the body in movement generates interactively architectural SPACE. The input – movement – is being electronically processed in such a way that the output represents a continuous, real-time modification of the space. For this purpose an on-site-built InterFace employing sensor/actuator technology enables translation of the recorded movement into spatial configurations. The InterAction between the body and the architectural space gives insight into how the human body shapes space.
A randomly mutagenized xylose reductase increases the 1 ethanol productivity in xylose-utilizing Saccharomyces 2 cerevisiae

1 Baker’s yeast Saccharomyces cerevisiae has been genetically engineered to 2 ferment the pentose sugar xylose present in lignocellulose biomass. One of the reactions 3 controlling the rate of xylose utilization is catalyzed by xylose reductase (XR). In 4 particular, the cofactor specificity of XR is not optimized with respect to the downstream 5 pathway and the reaction rate is insufficient for high xylose utilization in S. cerevisiae. 6 The current study describes a novel approach to improve XR for ethanol production in S. 7 cerevisiae . The cofactor binding region of XR was mutated by error-prone PCR and the 8 resulting library was expressed in S. cerevisiae . The S. cerevisiae library expressing the 9 mutant XR was selected in sequential anaerobic batch cultivation. At the end of the 10 selection process, a strain (TMB 3420) harboring the XR mutations N272D and P275Q 11 was enriched from the library. The V max of the mutated enzyme was increased by an order 12 of magnitude compared to the native enzyme and the ratio of NADH/NADPH utilization 13 was increased significantly. The ethanol productivity from xylose in TMB 3420 was 14 increased ~ 40 times compared to the parent strain (0.32 g/gDW×h vs. 0.007 g/gDW×h), 15 and the anaerobic growth rate was increased from ~ 0 h -1 to 0.08 h -1 . The improved traits 16 of TMB 3420 were readily transferred to the parent strain by reverse engineering of the 17 mutated XR gene. Since integrative vectors were employed in the construction of the 18 library, transfer of the improved phenotype does not prerequisite multi-copy expression 19 from episomal plasmids.
Abattoir and Coprological Prevalence of Fasciolosis and its Vectors: Infection Intensity and Species Diversity

: A cross-sectional study was carried out to estimate the coprologic and abattoir prevalence as well as the burden of bovine and ovine fasciolosis.The study also identified the density of its vectors in endemic areas of central highland district of Ethiopia. The standard sedimentation and the McMaster egg counting techniques were used to determine the egg counts, estimation of herd egg output and subsequently the egg shedding index. Overall fasciola infections were only diagnosed in 605 (53.8%) animals coprologically. The highest prevalence was for sheep (60.1%) and followed by cattle (49.2%). The overall herd level infection prevalence, as estimated from the egg-shedding index, was 50.9±29.3. In both sheep and cattle, the highest and the lowest prevalence were observed during the months of November and April, respectively. In abattoir, about 1061 (81%) livers examined were positive for fasciolosis. F. hepatica was a dominant (87.9%) species identified followed by F. gigantica (6.3 %). Among the genera collected, Lymnaea species were the most abundant (1470) snail encountered. The present study plainly disclosed the high prevalence of fasciolosis both at herd and individual animal level and at abattoir survey. The eggs shedding index seemed to be useful approach in current epidemiological survey than the individual animal coprologic examination. The high pathogenecity of fasciolosis substantiate the need of at least one or two strategic treatment during the dry season. Further studies concerning the effects of altitudinal and climatic factors associated with the epidemiology of fasciolosis should be undertaken. higher prevalence of fasciolosis
THE POTENTIAL OF NEW URBANISM IN VILNIUS

Summary. In the wake of post-Soviet privatization, Vilnius has embraced westernized models for growth and development. The city is changing rapidly in a backlash against Soviet planning practice and with an influx of funding from the European Union and private investment. City plans aim for sustainable growth and development while tackling the revitalization of So-viet-era residential districts and control of suburban sprawl. This paper examines how planning efforts in Vilnius can benefit from the principles of New Urbanism as the reach of these popular American planning fundamentals provide convenient remedies to challenges in the redeveloping city.
Accelerating Commercialization of Wide-Bandgap Power Electronics [Expert View]

Silicon (Si) power devices have dominated power electronics because of their low-cost volume production, excellent starting material quality, ease of processing, and proven reliability. Although Si power devices continue to make significant progress, they are approaching their operational limits, primarily because of their relatively low bandgap and critical electric field, which result in high conduction and switching losses and in poor high-temperature performance. Si carbide (SiC) and gallium nitride (GaN) power devices are revolutionizing power electronics because of their favorable material properties, which allow for highly efficient power devices with a reduced form factor and reduced cooling requirements.
Challenges and Inspection Done on Some Businesses by the Department of Labour in the South African Government

This article surveys enactment administration in the South African Department of Labour considering at the protagonists of the national office, provincial offices and labour midpoints. The study objective was to recognise the glitches and hindrances in executing equally the structural and distinct enactment administration structure. The verdicts were that, though around are well advanced enactment administration outlines, they have not really been successfully implemented. There are four categories of obstructions distressing the application of enactment administration. The first category is that of problems of measurement and design. The second category is that of the gaming of the system and a lack of compliance in the signing and evaluation of individual performance agreements by senior officials. The third category is lack of capacity which includes inadequate information technology systems and poor quality of staff. The fourth category is that of accountability. There needs to be strong accountability of bureaucracies if performance is to be taken seriously and public bureaucracies are to work effectively. Afresh self-governing South Africa adopted New Public Management (NPM) reforms as part of its public service reform programme. Cameron (2009) in a 10-year review of the country’s public service reform argues that although there are elements of NPM in the South African government’s programme, they have been implemented in a lukewarm fashion. There are nevertheless well developed NPM frameworks, including elaborate organisational and individual performance management systems. This article examines enactment administration in the South African Department of Labour (DOL). Policy making resides in a relatively small national government department and implementation is the accountability of labour centres, which have a certain degree of autonomy in providing certain labour services. There are also provincial offices of the DOL whose function is to support labour centres. The article examines the two main components of the DOL, namely the Public Employment Services (PES) and Inspection Enforcement Services (IES). The research objective was to identify the problems and obstacles in implementing both the organisational
Chemical Composition and Antibacterial Activity of Essential Oil of Lantana camara L.

: The chemical constituents of essential oil from the fresh leaves of Lantana camara L. was examined by GC-FID and GC-MS technique. Hydro distillation method was used to extract the essential oil and the yield was 0.25%v/w. Forty-one components (93.25%) were identified, among the major components were -caryophyllene (27.0%), -humulene (11.8%), sabinene (9.7%), bicyclogermacrene (8.1%) and davanone (4.7%). The disc diffusion method was used for antibacterial testing. The essential oil exhibited significant antibacterial activity against Escherichia coli, Bacillus subtilis, Bacillus cereus and Staphylococcus aureus.
Immune factors in human embryo culture and their significance

Summary. There is increasing evidence that human development before implantation is regulated by embryonically and maternally derived growth factors. The “regulators” of embryonic origin such as soluble human leukocyte antigen G, platelet-activating factor, Th1/Th2 cytokines, insulin-like growth factor, epidermal growth factor, transforming growth factor α, colony-stimulating factor, platelet-derived growth factor may be used as indicators of embryo viability and implantation potential. The data prove the inﬂ uence of growth factors on the development and growth of preimplantation embryos. Though there is a lot of research in the field of biomarkers during folliculogen-esis and maternal-fetal interface, only few of them deal with regulators derived from embryonic cells to the cultivation medium. The aim of our study was to summarize the research dealing with immune markers produced by embryos in vitro and to estimate their impact on the cell growth, viability and implantation potential.