Miracle-dz/UniFAR-FTUs huggingface dataset:
Possibility of Subjective Quality of Life Improvement during Individual Music Intervention in Elderly People with Severe Dementia: The Pilot Study

Quality of Life (QOL) is a worldwide issue resulting from a sudden increase in dementia and is intensified by increasing severity consequent to decreasing cognitive function. Music therapy could potentially stimulate cognitive function people with dementia. However, relatively few studies have investigated QOL during music intervention. Therefore, we investigated the effects during an interactive music intervention on subjective QOL, as well as evaluation methods in elderly people with severe dementia. We performed behavioral analyses during group leisure activities in the weeks before and after interactive music intervention (once weekly for 5 weeks) using “music with a special personal meaning”. The participants were 3 elderly people with severe dementia. We measured emotional states and spontaneity to represent subjective QOL measurement, and combined a single-subject reversal design (A-B-A) with a multiple baseline design among the participants. Compared with the ratio during the participants’ leisure activities, their average “sustained attention” activity ratio during music intervention dramatically increased. Moreover, the average ratio of post-intervention during leisure activities was higher than one of pre-intervention. Furthermore, the average “fun”, “satisfaction”, and “spontaneous speech” activity ratios during music intervention also increased, comparing with leisure activities. Interactive intervention involving music with a special personal meaning activates attentional functions and awakens positive emotions in elderly people with severe dementia, suggesting a subjective QOL improvement. The behavioral analysis evaluation method used herein requires an analytical precision and limitation of dependent variables; however, it is an effective way to understand people with severe dementia and communication issues.
TITLE The Effects of Mothers and " Security " Blankets Upon Learning in Children

ABSTRACT This study investigated the effects of availability of a familiar human att4. -ment object (the mother) and familiar inanimate attachment ou, ct (the child's blanket) on a child's emotionality and learning of a discrimination task. A total of 64, land 3-year-old children were assigned to groups (nonattached, mother-attached, or blanket-attached), and given a simple conditioning-extinction-reconditioning task in an unfamiliar play setting. Children in the groups with either human or inanimate attachment did significantly better on the discrimination task with less visible distress than the children who had no attachment object available. The presence of the attachment objects also faciiitated the 2and 3-year-olds habituation to an unfamiliar environment.
Choice of Design Techniques for Scaling Mission Critical High Volume Applications

--In today’s Services business, self-servicing models with thousands of users operating “Anytime Anywhere” concurrently and generating millions of transactions have increased the performance requirements multi-fold. However, these systems are monolithic and are not flexible for business transformations and changes. To scale beyond this, many organizations have started to transform these systems to new generation of multi-core platforms. This being architecturally different, the existing applications will have to be decomposed and re-architected to run as parallel components, have near zero contention and take advantage of these new generation platforms. This paper studies the choice of design techniques with the elements of concurrency and parallelism to arrive at an optimal setup to scale the performance of high volume mission critical real time applications on modern platforms. The choices are further validated with the simulation runs conducted to narrow down the combination setup giving the best performance. The results, analysis and the recommendations aim to provide an approach to the design architects in transforming mission critical applications.
Modelling exchange rate volatility with random level shifts

Recent literature has shown that the volatility of exchange rate returns displays long memory features. It has also been shown that if a short memory process is contaminated by level shifts, the estimate of the long memory parameter tends to be upward biased. In this paper, we directly estimate a random level shift model to the logarithm of absolute returns of ve exchange rates series, in order to assess whether random level shifts can explain this long memory property. Our results show that there are few level shifts for the ve series, but once they are taken into account, the long memory property of the series disappears. We also provide out-of-sample forecasting comparisons, which show that, in most cases, the random level shift model outperforms the popular ARFIMA model in forecasting volatility. We further support our results using a variety of robustness checks. JEL Classi cation Number: C22, F37.
ASSIMILATION FOR WEAKLY DAMPED AND DRIVEN

We show that the global attractor of a weakly damped and driven Korteweg-de Vries equation (KdV) is embedded in the long-time dynamics of an ordinary diﬀerential equation called a determining form. In particular, there is a one-to-one identiﬁcation of the trajectories in the global attractor of the damped and driven KdV and the steady state solutions of the determining form. Moreover, we analyze a data assimilation algorithm (down-scaling) for the weakly damped and driven KdV. We show that given a certain number of low Fourier modes of a reference solution of the KdV equation, the algorithm recovers the full reference solution at an exponential rate in time.
Analysis of Role of Knowledge Management in Economic Growth

: K nowledge and ideas have been emerged as key drivers for the economic growth in current scenario. Firm specific, Sector specific and General knowledge are the three forms of knowledge that play a significant role in economic growth. The well qualified human capital has positive impact on economic growth through total factor productivity Past researches show that there is direct relationship between new ideas and human capital. As a result, investment in human capital led to growth in physical capital which in turn leads to economic growth. An attempt has been made to analyze the various factors affecting knowledge management and two economic growth models have been developed on the basis of those factors. Role of knowledge management in economic growth has been discussed by highlighting various important applications of knowledge management. This paper provide a light to the researcher for further development of scope of knowledge management in various economic sectors.
PREVENTIVE MEASURES; EDUCATIONAL PROGRAMS

Over the past twenty years there has been a series of research based educational and rehabilitation initiatives used to reduce drink driving in Queensland, Australia. This conceptual paper examines the implications of the variety of different approaches to education and rehabilitation they have employed. It is proposed that there needs to be both clarity and selectivity in targeting programmes and new strategies and approaches to implementation in this problem area. Four research based statewide and regional programmes are examined which include two high school programmes, a rehabilitation programme and a prevention programme designed for a juvenile detention centre population. The programmes are analysed in terms of targets, theoretical and pedagogical models, evaluation outcomes and implementation and continuity constraints. The findings demonstrate outcome effectiveness for well-designed behaviour change programmes and the need for programme designers to determine their target group and to focus programmes on the target’s particular needs. It is possible to define a general school population and its need for knowledge, information and appropriate social skills however ensuring continuity for such programmes is a major problem. Evaluation findings also indicate that there may be very different theoretical paradigms required for effective programmes for those who already have involvement in drink driving and other criminal behaviours. Research and educational attention should move to selecting and trialing the types of theoretical paradigms and implementation strategies that are relevant for particular and diverse groups. Attention is drawn to the problems faced by model interventions in finding and establishing a continuing role in densely packed and dynamic school curricula and proposes possible alternative approaches. Finally, the very different situation of the programme poor environment of juvenile detention centres and the competing personal and developmental issues faced by these young persons is discussed. Background Over the past twenty years the Centre for Accident Research and Road Safety in Queensland has been involved in a series of research based educational initiatives to reduce drink driving by young people. Not unlike other western countries in the late seventies and early eighties transport and health authorities became deeply concerned by the high incidence of alcohol affected young people in the road fatality tolls. In Australia, more than half the fatal crashes
Machine Learning Techniques Applied to Human-Robot Collaboration

— Human-robot collaboration (HRC) is one of the hot topics in the robotics community in the last years, under the Industry 4.0 paradigm. Collaborative robots reduce human-operator fatigue and the risk of injuries, being a safe working buddy. With this aim, this contribution proposes a variable impedance control algorithm exploiting a Model-Based Reinforcement Learning (MBRL) impedance controller to assist human-operators in collaborative tasks, reducing his/her physical effort. An ensemble of neural networks (ANNs) is used to learn a human-robot interaction dynamics model, catching dynamics uncertainties. Such learned model is then used by a model predictive controller (MPC) with cross-entropy method (CEM) to online optimize the impedance control parameters ( i.e. , stiffness and damping parameters). The proposed approach will be validated through an experimental procedure (a FRANKA Emika manipulator will be used as a test platform) involving a lifting task of an unknown payload (3 kg), comparing the obtained results with model-free optimization control strategies.
The Development and Evaluation of Procedures to Assess Child Self-report Item Validity

Cognitive pretesting (CP) is an interview methodology for pretesting the validity of items during the development of self-report instruments. The present research evaluates a systematic approach to the analysis of CP data. Materials and procedures were developed to rate self-report item performance with CP interview text data. Five raters were trained in the application of that system. Estimates of inter-rater reliability found acceptable to substantial levels of inter-rater agreement. Results from the present study suggest that excellent inter-rater reliability can be achieved in the evaluation of CP data. Guidelines for systematically rating the qualitative data collected using CP methods are provided. Future research should focus on empirical demonstrations of how such rating procedures can lead to improvements in self-report instruments. during the construction of the Elementary School Success Profile (ESSP) child questionnaire (Bowen et al., 2004), a self-report instrument for use with children in middle childhood. The CP data coding system reported here includes two components: a validity codebook detailing item performance rating criteria and procedures, and rater training in the application of those criteria and procedures. The efficacy of these procedures is evaluated by assessing the inter-rater reliability achieved when five trained raters apply the rating system.
Quantitation and Localization Peripheral Mononulear Cells: Molecular Marker of Human Mucosal But Not Substance P (Neurokinin-1) Receptor Is a

Reciprocal communication between the immune sytem and the neuroendocrine system is mediated via a common chemical language of shared ligands and receptors. The neuropeptide substance P (SP) has been implicated as a mediator of immuno-modulation. The evidence for substance P receptors on human lymphocytes is, however, controversial. The aims of the present study are to investigate substance P receptor (SPR) expression in human peripheral and mucosal mononuclear cells and to identify cellular sites of expression in human colonic mucosa. Using reverse-transcriptase PCR, we demonstrate that PBMC isolations are negative for SPR mRNA expression, whereas lamina propria mononuclear cell (LPMC) isolations express on average eight SPR mRNA transcripts per cell. In situ hybridization performed on surgically resected colonic tissue conﬁrms the expression of SPR mRNA in LPMC in vivo. SPR mRNA signal was detected in LPMC, lymphoid follicles, and epithelium. The complementary technique of immunohistochemistry gave a similar distribution of SPR expression that colocalized with CD45 immunoreactivity. Dual-ﬂuorochrome ﬂow cytometry revealed SPR expression by CD4, CD45RO, CD45RA, CD8, CD19, and CD14 LPMC subsets, but not PBMC. Our ﬁndings suggest that SPR expression is distinctive of human colonic mucosal mononuclear cells and support a direct role for SP in mucosal immunomodulation. The Journal of Immunology, 1998, 161: 2232–2240. bidirectional communication between the nervous system and the system. Intersystem cross-talk is by common
the substantiation of health claims related to various constituent(s) supported

human studies, which investigated the effects of the food(s)/food constituent(s) on appropriate measures of the claimed effects, were provided. The Panel considers that no conclusions can be drawn from any of the references provided for the scientific substantiation of the claims evaluated in this opinion. On the basis of the data presented, the Panel concludes that a cause and effect relationship has not been established between the consumption of the food(s)/food constituent(s) and the claimed effects evaluated in this opinion.
OTT_A_266085 10499..10513

1Mayo Clinic Florida Division of Hematology Oncology, Jacksonville, FL 32224, USA; 2Mayo Clinic Florida Department of Cancer Biology, Jacksonville, FL 32224, USA Abstract: The majority of patients with castrate-resistant prostate cancer will have metastatic disease at the time of diagnosis. Investigative efforts on new therapeutics for this patient population have improved with the development of androgen signaling inhibitors, such as abiraterone and enzalutamide, and PARP inhibitors, such as rucaparib and olaparib, to accompany the previously FDA-approved docetaxel, cabazitaxel, sipuleucel-T, and Radium 223. However, new therapeutic strategies are necessary to prolong survival as progression after these agents is inevitable. CDK4/6 inhibitors have advanced the field of estrogen receptor positive breast cancer treatment and are being investigated in prostate cancer given the role of androgen receptor signaling effects on the cell cycle. Response to CDK4/6 inhibitors may be predicted by the tumors’ genomic profile and may provide insight into combinatory therapy with CDK4/6 inhibitors in order to delay resistance or provide synergistic effects. Here, we review the use of CDK4/6 inhibitors in prostate cancer and potential combinations based on known resistance mechanisms to CDK4/6 inhibitors, prostate cancer regulatory pathways, and prostate-cancer-specific genomic alterations.
Complement Activation Lipopolysaccharide Is Independent of Acute Lung Injury Induced by

Although acute lung injury (ALI) is an important problem in humans, its pathogenesis is poorly understood. Airway instillation of bacterial LPS, a known complement activator, represents a frequently used model of ALI. In the present study, pathways in the immunopathogenesis of ALI were evaluated. ALI was induced in wild-type, C3 (cid:1) / (cid:1) , and C5 (cid:1) / (cid:1) mice by airway deposition of LPS. To assess the relevant inﬂammatory mediators, bronchoalveolar lavage ﬂuids were evaluated by ELISA analyses and various neutralizing Abs and receptor antagonists were administered in vivo. LPS-induced ALI was neutrophil-dependent, but it was not associated with generation of C5a in the lung and was independent of C3, C5, or C5a. Instead, LPS injury was associated with robust generation of macrophage migration inhibitory factor (MIF), leukotriene B 4 (LTB4), and high mobility group box 1 protein (HMGB1) and required engagement of receptors for both MIF and LTB4. Neutralization of MIF or blockade of the MIF receptor and/or LTB4 receptor resulted in protection from LPS-induced ALI. These ﬁndings indicate that the MIF and LTB4 mediator pathways are involved in the immunopathogenesis of LPS-induced experimental ALI. Most strikingly, complement activation does not contribute to the development of ALI in the LPS model. The Journal of Immunology, 2008, 180: 7664–7672. the molecular mechanisms of acute lung injury (ALI),
Reticulum Calreticulin to MHC Class I in the Transferred Sequentially from gp96 and Ovalbumin-Derived Precursor Peptides Are

Cellular peptides generated by proteasomal degradation of proteins in the cytosol and destined for presentation by MHC class I (MHC-I) are associated with several chaperones. Heat shock proteins 70, 90, and the TCP-1 ring complex have been implicated as important cytosolic players for chaperoning these peptides. In this study, we report that gp96 and calreticulin are essential for chaperoning peptides in the endoplasmic reticulum. Importantly, we demonstrate that cellular peptides are transferred sequentially from gp96 to calreticulin and then to MHC-I forming a relay line. Disruption of this relay line by removal of gp96 or calreticulin prevents the binding of peptides by MHC-I and hence presentation of the MHC-I–peptide complex on the cell surface. Our results are important for understanding how peptides are processed and trafﬁcked within the endoplasmic reticulum before exiting in association with MHC-I H chains and b 2-microglobulin as a trimolecular complex. The Journal of Immunology , 2010, 184: 000–000.
Mechanical and tribological properties of FFF 3D-printed polymers: A brief review

classification-based literature review was performed on the mechanical and tribological properties of 3D-printed polymers. Kim et al., (2017) investigated the mechanical properties of single and dual-material 3D-printed products using PLA and ABS filaments via full factorial design of experiment (DOE) and analysis of variance (ANOVA). The investigation was performed by varying the infill percentages at 50% and 100% with orientation directions of x-axis, y-axis, and 45° angle. The findings showed that dual-material 3D-printed products have an average ultimate tensile strength of 43.26 MPa compared to single-material 3D-printed products. 3D-printed materials using PLA in the x-direction and with an infill percentage of 100% gave the best mechanical properties with a surface roughness of 1.938 μm. Moreover, the orientation direction in AM samples contributed to its anisotropic properties (Ahn et al., 2002). Hence, these infill and orientation direction factors improved the mechanical properties of 3D-printed products making them more rigid and firm. The compressive effect of internal structures and pattern on mechanical properties was examined by Galeta et al., (2016). A honeycomb structure (H) 3D-printed along the y-axis in a plaster-based powder zp130, with an appropriate binder zb56 (Z310 printer) had a maximum tensile strength of 13.92 MPa. The maximum (1.78 MPa/g) and minimum (0.21 MPa/g) results of specific tensile strengths at failure break were achieved in the same honeycomb data set. Similarly, Domínguez-Rodríguez examined the 3D-printed structures filled with honeycomb patterns in the longitudinal direction (0/90 40%) and found that the honeycomb structure had the most effective stiffness and strength properties compared to rectangular patterns. The combination of local plastic deformation and buckling between interchange layers contributed significantly to the properties 1991).
GENDER AND EFFORTFUL AVOIDANCE 1 Gender and comorbidity moderate the relationship between mood disorder

3 We must often decide how much effort to exert or withhold to avoid undesirable outcomes 4 or obtain rewards. In depression and anxiety, levels of avoidance tend to be excessive and 5 reward-seeking is reduced. Yet outstanding questions remain about the links between 6 motivated action/inhibition and anxiety and depression symptoms, and whether they differ 7 between men and women. Here we examined the relationship between anxiety and 8 depression symptoms and performance on effortful active and inhibitory avoidance (Study 9 1) and reward seeking (Study 2) in humans. Undergraduates and paid online workers 10 (NAvoid = 545, NReward = 310; NFemale = 368, NMale = 450, MAge = 22.58, RangeAge = 17-62) 11 were assessed on the Beck Depression Inventory (BDI-II) and the Beck Anxiety Inventory 12 (BAI) and performed an instructed online avoidance or reward-seeking task. Participants 13 had to make multiple presses on active trials and withhold presses on inhibitory trials to 14 avoid an unpleasant sound (Study 1) or obtain points towards a monetary reward (Study 15 2). Overall, men deployed more effort than women in both avoidance and reward-seeking, 16 and anxiety symptoms were negatively associated with active reward-seeking accuracy. 17 Gender moderated the relationship between anxiety symptoms and inhibitory avoidance, 18 such that women with higher anxiety showed reduced inhibitory avoidance accuracy. 19 Anxiety symptoms predicted poorer active avoidance performance for those high in 20 depression symptoms only. Our results illuminate effects of gender and symptom 21 comorbidity in the relationship between mood disorder symptoms and the motivation to 22 actively and effortfully respond to obtain positive and avoid negative outcomes. 23
Sulphilimine/Sulfilimine cross‐links in Goodpasture's disease

The sulphilimine/sulfilimine cross‐link of the Goodpasture (GP) autoantigen is a novel molecular mechanism (structural constraint) for conferring immune privilege to a site which otherwise is susceptible to structural changes that induce an immunogenic and pathogenic conformation. Perturbation of the assembly or cleavage of the sulphilimine/sulfilimine cross‐links could be a key factor in the aetiology of Goodpasture's disease in susceptible individuals.
AlGaAs/Si dual‐junction tandem solar cells by epitaxial lift‐off and print‐transfer‐assisted direct bonding

A novel method is developed to realize a III‐V/Si dual‐junction photovoltaic cell by combining epitaxial lift‐off (ELO) and print‐transfer‐assisted bonding methods. The adoption of ELO enables III‐V wafers to be recycled and reused, which can further lower the cost of III‐V/Si photovoltaic panels. For demonstration, high crystal quality, micrometer‐thick, GaAs/AlGaAs/GaAs films are lifted off, transferred, and directly bonded onto Si wafer without the use of any adhesive or bonding agents. The bonding interface is optically transparent and conductive both thermally and electrically. Prototype AlGaAs/Si dual‐junction tandem solar cells have been fabricated and exhibit decent performance.