Miracle-dz/UniFAR-FTUs huggingface dataset:
Control strategy of a novel energy recovery system for parallel hybrid hydraulic excavator

With the high fuel prices, the demands for energy saving and green emission of engineering machinery have been increased rapidly. Due to the complex working condition and frequent load changing, the efficiency of the hydraulic excavator is low. The aim of this article is to propose a control strategy for energy recovery system of hydraulic excavator driven by the parallel hybrid system. The mathematical models of the main components and the simulation models of the proposed system and a conventional energy recovery system are built. Then, according to the load characteristic, a control strategy based on the working condition and state of charge of the battery is given. The co-simulation for the hybrid hydraulic excavator system is established. The results show that the proposed energy recovery system and control strategy can not only improve the energy recovery efficiency but also reduce fuel consumption and emission of the power system.
Finding Biomarkers in Antioxidant Molecular Mechanisms for Ensuring Food Safety of Bivalves Threatened by Marine Pollution

Aquaculture production as an important source of protein for our diet is sure to continue in the coming years. However, marine pollution will also likely give rise to serious problems for the food safety of molluscs. Seafood is widely recognized for its high nutritional value in our diet, leading to major health benefits. However, the threat of marine pollution including heavy metals, persistent organic pollutants and other emerging pollutants is of ever-growing importance and seafood safety may not be guaranteed. New approaches for the search of biomarkers would help us to monitor pollutants and move towards a more global point of view; protocols for the aquaculture industry would also be improved. Rapid and accurate detection of food safety problems in bivalves could be carried out easily by protein biomarkers. Hence, proteomic technologies could be considered as a useful tool for the discovery of protein biomarkers as a first step to improve the protocols of seafood safety. It has been demonstrated that marine pollutants are altering the bivalve proteome, affecting many biological processes and molecular functions. The main response mechanism of bivalves in a polluted marine environment is based on the antioxidant defense system against oxidative stress. All these proteomic data provided from the literature suggest that alterations in oxidative stress due to marine pollution are closely linked to robust and confident biomarkers for seafood safety.
An Occlusion Aware Five-view Stereo System and Its Application in Video Post-production

Extracting the live-action elements from videos has been a time-consuming process in the post-production pipeline. The disparity map, however, shows the order of elements in a scene by indicating the distance between the elements and the camera, which could potentially become an effective tool for separating videos into ordered layers and preserving the 3D structure of the elements. In this research, we explored the possibility of simplifying the live-action video element extraction technique with disparity sequences. We developed a five-view disparity estimation and enhancement system with a two-axis setup that helps reduce the occlusions in stereo vision. The system is independent from temporal reconstruction hence is compatible with both dynamic and stationary camera paths. Our results show that the disparities from our system have visually and quantitatively better performance than the traditional binocular stereo method, and its element extraction result is comparable with the existing mature matting techniques in most cases. Ideally, the system design could be applied in cinematography by replacing the center camera with a cinematographic camera, and the output can be used for video object extraction, visual effects composition, video’s 2D to 3D conversion, or producing the training data for neural-network-based depth estimation research.
Global Genomic and Proteomic Analysis Identified Critical Pathways Modulated by Proto-Oncogene PELP1 in TNBC

Simple Summary The proto-oncogene PELP1 is commonly overexpressed in many cancers including triple negative breast cancer (TNBC). In this study, we utilized global proteomic and RNA-seq approaches to elucidate the molecular mechanisms by which PELP1 contributes to the progression of TNBC. Global quantitative proteome analysis revealed that the oncogenic activities of PELP1 involve regulation of the expression of ribosomal proteins, as well as ribosomal regulatory complexes. RNA-seq studies discovered that PELP1 modulates the functions of c-Myc in TNBC, which is a known regulator of ribosomal proteins. Furthermore, TCGA-TNBC data confirmed PELP1 has high expression in TNBC, and this pattern exhibited a positive correlation with c-Myc and regulators of ribosomal proteins. Collectively, our studies suggest that PELP1 contributes to TNBC progression by modulation of ribosome biogenesis pathways. Abstract The PELP1 oncogene is commonly overexpressed in many cancers, including triple negative breast cancer (TNBC). However, the mechanisms by which PELP1 contributes to TNBC progression are not well understood. To elucidate these mechanisms, we generated CRISPR-Cas9 mediated PELP1 knockout TNBC cell lines, and alterations in the proteome were examined using global data-independent acquisition mass spectrometry (DIA-MS). Further mechanistic studies utilized shRNA knockdown, Western blotting, and RNA-seq approaches. TCGA data sets were utilized for determining the status of PELP1 in TNBC patient tumors and for examining its correlation with ribosomal proteins. Global DIA-MS studies revealed that 127 proteins are upregulated while 220 proteins are downregulated upon PELP1-KO. Bioinformatic analyses suggested that the oncogenic activities of PELP1 involve regulation of expression of ribosomal proteins and ribosomal complexes. RNA-seq studies further suggested PELP1 modulates the functions of transcription factor c-Myc in TNBC. TCGA data confirmed PELP1 has high expression in TNBC patient tumors, and this high expression pattern correlates with c-Myc, a regulator of ribosomal proteins. Collectively, our global approach studies suggest that PELP1 contributes to TNBC progression by modulation of cell cycle, apoptosis, and ribosome biogenesis pathways.
Glacial geomorphology and chronology in the Selamiut Range - Nachvak Fiord area, Torngat Mountains, Labrador

The summits of the Selamiut Range are the highest in the Torngat Mountains of northern Labrador and contain some of the only permanent ice bodies of the eastern Canadian mainland. As they may have constituted a physical barrier to ice moving eastward from the Ungava ice-dispersal centre, their glacial history is elaborate in a regional context. Consequently a complex interaction of local and regional ice masses is manifest in the morphochronological record dating from the Late Quaternary through the Holocene. -- Physiographically the Selamiut Range is a plateau, dominated by deep cirques and cirque outlet valleys with precipitous bounding rock walls. Colluvial processes are extremely active and consequently many surficial units have been extensively remodelled in dynamic landscape systems. -- The northern half of the field area contains a wealth of glacial and periglacial landform assemblages and former local and regional ice activity has been determined from the cross-cutting relationships of certain morainic features. -- Within the McCornick River Valley a sequence of shorelines documents the depths and extent of ice-dammed lakes during glaciation. A further 33 metre marine limit demarcates former sea level during the final glaciation of the area. -- Three glaciations or stillstands are suggested for the field area after consideration of the landform evidence and are named the Ivitak, Nachvak and Superguksoak Glaciations. -- The adoption of a 1.5 cm ka ⁻¹ soil development rate dates the three glaciations or stillstands for the Selamiut/Nachvak area; the Ivitak Glaciation at >>40 ka; the Nachvak Glaciation at c.23 ka; and the Superguksoak I Glaciation at 10-12 ka. B.P. Two further Neoglacial events were restricted to the cirque basins and are correlated locally by a combination of pedology, lichenometry and morphologic superimposition. -- A number of chronocorrelative inferences are made for northern Labrador based upon the existing empirical data. Glacial styles appear to differ quite considerably from fiord to fiord along the coastal section of the Torngat Mountains. The solution of discrepancies within the general northern Labrador chronology resides in the successful construction of an absolute dating framework for the marine limits of the region. Relative chronologies may then attain a significant applicability.
Hybrid MBlur: A Systematic Approach to Augment Rasterization with Ray Tracing for Rendering Motion Blur in Games

Motion blur is commonly used in game cinematics to achieve photorealism by modelling the behaviour of the camera shutter and simulating its effect associated with the relative motion of scene objects. A common real-time post-process approach is spatial sampling, where the directional blur of a moving object is rendered by integrating its colour based on velocity information within a single frame. However, such screen space approaches typically cannot produce accurate partial occlusion semi-transparencies. Our real-time hybrid rendering technique leverages hardware-accelerated ray tracing to correct post-process partial occlusion artifacts by advancing rays recursively into the scene to retrieve background information for motion-blurred regions, with reasonable additional performance cost for rendering game contents. We extend our previous work with details on the design, implementation, and future work of the technique as well as performance comparisons with post-processing.
A Multivariate Analysis of Depression Prevalence in Psoriasis Patients: A Cohort Study

The literature reported higher depression rates in psoriasis patients compared to the general population. Our study aimed to verify whether variability in depression prevalence was due to using different diagnostic tools. We also aimed to determine whether dysfunctional coping strategies might increase the depression burden. We assessed psoriasis severity by the Psoriasis Area Severity Index (PASI) and PSOdisk. We analyzed mental alterations of 120 outpatients by Hamilton Depression and Anxiety Rating Scales (HAM-D and HAM-A), Symptom Checklist-90-Revised (SCL-90-R), plus coping strategies and quality of life by Coping Orientation to Problems Experienced (COPE) Inventory and 36-Item Short Form Health Survey (SF-36). We divided our cohort into five subgroups from minimal to severe psoriasis using the PSOdisk total score. Depression prevalence varied according to the assessment criteria for specificity, frequency, and severity. Different mood disorders other than major depression emerged when we used DSM-IV-TR criteria. Correlation analysis of the criteria we used to diagnose depression or depressed mood indicated that a dysfunctional coping strategy was highly and positively correlated only in patients of the severe subgroup. Differently, a negative correlation emerged between the SF-36 Mental Summary Component (MSC) and behavioral disengagement, thus suggesting that psychopathological distress might induce patients with a marked/severe psoriasis to adopt dysfunctional coping strategies. Dermatologists are fundamental in detecting comorbid depression, referring psoriasis patients to mental health specialists to achieve adequate treatments, and preventing suicide risk.
Proprioceptive and Visual Feedback Responses in Macaques Exploit Goal Redundancy

A common problem in motor control concerns how to generate patterns of muscle activity when there are redundant solutions to attain a behavioral goal. Optimal feedback control is a theory that has guided many behavioral studies exploring how the motor system incorporates task redundancy. This theory predicts that kinematic errors that deviate the limb should not be corrected if one can still attain the behavioral goal. Studies in humans demonstrate that the motor system can flexibly integrate visual and proprioceptive feedback of the limb with goal redundancy within 90 ms and 70 ms, respectively. Here, we show monkeys (Macaca mulatta) demonstrate similar abilities to exploit goal redundancy. We trained four male monkeys to reach for a goal that was either a narrow square or a wide, spatially redundant rectangle. Monkeys exhibited greater trial-by-trial variability when reaching to the wide goal consistent with exploiting goal redundancy. On random trials we jumped the visual feedback of the hand and found monkeys corrected for the jump when reaching to the narrow goal and largely ignored the jump when reaching for the wide goal. In a separate set of experiments, we applied mechanical loads to the arm of the monkey and found similar corrective responses based on goal shape. Muscle activity reflecting these different corrective responses were detected for the visual and mechanical perturbations starting at ∼90 and ∼70 ms, respectively. Thus, rapid motor responses in macaques can exploit goal redundancy similar to humans, creating a paradigm to study the neural basis of goal-directed motor action and motor redundancy. SIGNIFICANCE STATEMENT Moving in the world requires selecting from an infinite set of possible motor commands. Theories predict that motor commands are selected that exploit redundancies. Corrective responses in humans to either visual or proprioceptive disturbances of the limb can rapidly exploit redundant trajectories to a goal in <100 ms after a disturbance. However, uncovering the neural correlates generating these rapid motor corrections has been hampered by the absence of an animal model. We developed a behavioral paradigm in monkeys that incorporates redundancy in the form of the shape of the goal. Critically, monkeys exhibit corrective responses and timings similar to humans performing the same task. Our paradigm provides a model for investigating the neural correlates of sophisticated rapid motor corrections.
Pickering Emulsions Stabilized with Curcumin-Based Solid Dispersion Particles as Mayonnaise-like Food Sauce Alternatives

Pickering emulsions, which are emulsions stabilized by colloidal particles, are being increasingly positioned as novel strategies to develop innovative food product solutions. In this context, the present work aims to develop Pickering emulsions stabilized by natural-based curcumin-loaded particles produced by the solid dispersion technique as promising mayonnaise-like food sauce alternatives. Two particle formulations (KC1 and KC2) were produced using k-carrageenan as the matrix material and different curcumin contents, then employed in the preparation of three Pickering emulsion formulations comprising different oil fractions (φ) and particle concentrations (KC1 φ 0.4 (4.7%), KC2 φ 0.4 (4.7%) and KC2 φ 0.6 (4.0%)). The creaming index tests accompanied by the optical microscopy analysis evidenced the good stability of the developed products for the tested period of 28 days. The final products were tested concerning color attributes, pH, oxidative stability, textural, and nutritional composition, and compared with two commercial mayonnaises (traditional and light products). Overall, the produced emulsions were characterized by a bright yellow color (an appealing attribute for consumers), an acidic pH (similar to mayonnaise), and a considerably improved oxidative stability, implying a foreseeable longer shelf life. The sauce KC1 φ 0.4 (4.7%) showed a similar texture to the light commercial mayonnaise, being a promising alternative to conventional sauces, holding a low-fat content and potentially added benefits due to the curcumin and virgin olive oil intrinsic properties.
Derivation Factors of Smart Space Awareness for Effective CPTED

Crime prevention activities that take place in the physical environment, such as police patrolling, can work effectively when they are combined with intelligent detection that uses information technology (IT). Many different real-world factors must be considered when implementing intelligent detection methods. In risky real-world situations, fixed factors, static factors, and a variety of dynamic factors all play important roles. This study aimed to determine the variable factors involved in risky situations by performing an analysis on data from specific crime incidents. Factors related to the occurrence of the specific crime were determined and risk of occurrence was calculated using these factors with a multi-factor convergence scheme. The analysis and risk calculation performed in this study are expected to contribute to the development of a more efficient and intellectualized prevention service, as these can help provide information about real-time risk levels for particular public safety situations.
TRPV4 Inhibition Exerts Protective Effects Against Resistive Breathing Induced Lung Injury

Introduction TRPV4 channels are calcium channels, activated by mechanical stress, that have been implicated in the pathogenesis of pulmonary inflammation. During resistive breathing (RB), increased mechanical stress is imposed on the lung, inducing lung injury. The role of TRPV4 channels in RB-induced lung injury is unknown. Materials and Methods Spontaneously breathing adult male C57BL/6 mice were subjected to RB by tracheal banding. Following anaesthesia, mice were placed under a surgical microscope, the surface area of the trachea was measured and a nylon band was sutured around the trachea to reduce area to half. The specific TRPV4 inhibitor, HC-067047 (10 mg/kg ip), was administered either prior to RB and at 12 hrs following initiation of RB (preventive) or only at 12 hrs after the initiation of RB (therapeutic protocol). Lung injury was assessed at 24 hrs of RB, by measuring lung mechanics, total protein, BAL total and differential cell count, KC and IL-6 levels in BAL fluid, surfactant Protein (Sp)D in plasma and a lung injury score by histology. Results RB decreased static compliance (Cst), increased total protein in BAL (p < 0.001), total cell count due to increased number of both macrophages and neutrophils, increased KC and IL-6 in BAL (p < 0.001 and p = 0.01, respectively) and plasma SpD (p < 0.0001). Increased lung injury score was detected. Both preventive and therapeutic HC-067047 administration restored Cst and inhibited the increase in total protein, KC and IL-6 levels in BAL fluid, compared to RB. Preventive TRPV4 inhibition ameliorated the increase in BAL cellularity, while therapeutic TRPV4 inhibition exerted a partial effect. TRPV4 inhibition blunted the increase in plasma SpD (p < 0.001) after RB and the increase in lung injury score was also inhibited. Conclusion TRPV4 inhibition exerts protective effects against RB-induced lung injury.
Vedolizumab Attenuates Immune-Checkpoint-Therapy-Induced Infliximab-Refractory Colitis

Immune checkpoint inhibitors (ICIs), such as nivolumab and ipilimumab, have drastically changed treatments of advanced melanoma. However, ICI-related enterocolitis is often the most common adverse event, and represents the main reason for ICI discontinuation and mortalities. Here, we report the case of a metastatic melanoma treated with vedolizumab for ICI-induced colitis. A 67-year-old man treated with ipilimumab and nivolumab developed ICI-induced colitis and grade 3 diarrhea refractory to methylprednisolone and infliximab. After his third dose of vedolizumab, oral prednisolone ceased, and the colitis had completely resolved with no recurrence. This case report supports vedolizumab use in treating severe colitis which failed to resolve with first- and second-line immunosuppressive therapy.
Relationships between Physical Activity Parenting Practices and Children’s Activity Measured by Accelerometry with Children’s Activity Style as a Moderator—A Cross Sectional Study

The objective was to examine the associations between physical activity parenting practices (PAPP) and children’s levels of moderate-to-vigorous physical activity (MVPA), and time spent sedentary (SED) during non-school time in weekdays and weekends when children’s activity style was taken into account. Study participants were 88 children (mean age 6.3 (SD 0.3) years); 51.0% girls) and their parents who took part in A Healthy School Start Plus in Sweden. The independent variables included PAPPs Structure, Neglect/control, and Autonomy promotion and children’s activity style as moderator, assessed through validated parent questionnaires. Dependent variables were the MVPA and SED in minutes, measured by accelerometry. Structural equation modeling was used to examine the associations between PAPPs and children’s MVPA and SED with children’s activity style as a moderator. No significant associations between the PAPPs Structure, Neglect/control, and Autonomy promotion and measures of physical activity were found (p > 0.13). The moderating role of activity style improved the model fit and the final model had a reasonable fit to the data. Our results suggest that in future studies, with the aim to explore the relationship between PAPP and children’s physical activity, the activity style of the children should be included as a moderator.
Pathogens and Antibiotic Susceptibilities of Global Bacterial Keratitis: A Meta-Analysis

Bacterial keratitis (BK) is the most common type of infectious keratitis. The spectrum of pathogenic bacteria and their susceptibility to antibiotics varied with the different regions. A meta-analysis was conducted to review the global culture rate, distribution, current trends, and drug susceptibility of isolates from BK over the past 20 years (2000–2020). Four databases were searched, and published date was limited between 2000 and 2020. Main key words were “bacterial keratitis”, “culture results” and “drug resistance”. Forty-two studies from twenty-one countries (35 cities) were included for meta-analysis. The overall positive culture rate was 47% (95%CI, 42–52%). Gram-positive cocci were the major type of bacteria (62%), followed by Gram-negative bacilli (30%), Gram-positive bacilli (5%), and Gram-negative cocci (5%). Staphylococcus spp. (41.4%), Pseudomonas spp. (17.0%), Streptococcus spp. (13.1%), Corynebacterium spp. (6.6%) and Moraxella spp. (4.1%) were the most common bacterial organism. The antibiotic resistance pattern analysis revealed that most Gram-positive cocci were susceptive to aminoglycoside (86%), followed by fluoroquinolone (81%) and cephalosporin (79%). Gram-negative bacilli were most sensitive to cephalosporin (96%) and fluoroquinolones (96%), followed by aminoglycoside (92%). In Gram-positive cocci, the susceptibility trends of fluoroquinolones were decreasing since 2010. Clinics should pay attention to the changing trends of pathogen distribution and their drug resistance pattern and should diagnose and choose sensitive antibiotics based on local data.
Dynamically-Tunable Dataflow Architectures Based on Markov Queuing Models

Dataflow architectures are fundamental to achieve high performance in data-intensive applications. They must be optimized to elaborate input data arriving at an expected rate, which is not always constant. While worst-case designs can significantly increase hardware resources, more optimistic solutions fail to sustain execution phases with high throughput, leading to system congestion or even computational errors. We present an architecture to monitor and control dataflow architectures that leverage approximate variants to trade off accuracy and latency of the computational processes. Our microarchitecture features online prediction based on queuing models to estimate the response time of the system and select the proper variant to meet the target throughput, enabling the creation of dynamically-tunable systems.