Miracle-dz/UniFAR-FTUs huggingface dataset:
Hemostasis Components as Therapeutic Targets in Autoimmune Demyelination

Several studies in both multiple sclerosis (MS) and experimental autoimmune encephalitis (EAE) have shed light on the vascular mechanisms contributing to MS pathogenesis. The dysregulation of the hemostatic pathways revealed to play a pivotal role. Here, we review the numerous findings providing evidence on the involvement of hemostasis components in MS pathogenesis to highlight why they might be considered potential therapeutic targets in the disease. A literature search for articles from January 1950 to September 2021 was conducted in PubMed and Scopus. A consistent body of evidence supports the pro‐inflammatory activity of activated platelets in MS pathogenesis and the beneficial effect of aspirin administration on the EAE clinical course. Further, neuropathological findings in subjects with MS and experimental studies in EAE have revealed dysregulation of coagulation/fibrinolysis system in autoimmune demyelination. Fibrin deposition in the central nervous system and its interaction with the CD11b receptor on microglia cells seems to drive neuroinflammation and autoimmune demyelination. However, at present, few and controversial clinical data are available on the implementation of drugs targeting fibrin deposition in MS therapy. In conclusion, targeting platelet activation and receptors for fibrin(ogen) deserve further research to hopefully purpose new drugs in the pharmacologic paraphernalia of MS neurologists.
Electrocardiographic Characteristics and Their Correlation with Echocardiographic Alterations in Fabry Disease

Fabry disease (FD) is an X-linked disorder with α-galactosidase A deficiency. Males (>30 years) and females (>40 years) often present with cardiac manifestations, predominantly left ventricular hypertrophy (LVH). The aim of this study was to evaluate electrocardiographic (ECG) characteristics within FD patients to identify gender related differences, and to additionally explore the association of ECG parameters with structural and functional alterations on transthoracic echocardiography (TTE). Retrospective cross-sectional analysis of 45 FD patients with contemporaneous ECG and TTE was performed and compared to age and gender matched healthy controls. FD patients demonstrated alterations in several ECG parameters particularly in males, including prolonged P-wave duration (91 vs. 81 ms, p = 0.022), prolonged QRS duration (96 vs. 84 ms, p < 0.001), increased R-wave amplitude in lead I (8.1 vs. 5.7 mV, p = 0.047), increased Sokolow–Lyon index (25 vs. 19 mV, p = 0.002) and were more likely to meet LVH criteria (31% vs. 7%, p = 0.006). FD patients with impaired basal longitudinal strain (LS) on TTE were more likely to meet LVH criteria (41% vs. 0%, p = 0.018). Those with more advanced FD (increased LV wall thickness on TTE) were more likely to meet LVH criteria but additionally demonstrated prolonged ventricular depolarization (QRS duration 101 vs. 88 ms, p = 0.044). Therefore, alterations on ECG demonstrating delayed atrial activation, delayed ventricular depolarization and evidence of LVH were more often seen in male FD patients. Impaired basal LS, a TTE marker of early cardiac involvement, correlated with ECG abnormalities. Increased LV wall thickness on TTE, a marker of more advanced FD, was associated with more severe ECG abnormalities.
A methodological review on the characterization of microalgal biofilm and its extracellular polymeric substances

Biofilm secreted by microalgae are extracellular polymeric substances (EPSs) composed mainly of polysaccharides, proteins, nucleic acids and lipids. These EPSs immobilize the cells and stabilize biofilm, mediating adhesion towards solid surfaces. The EPSs valorization through industrial exploitations and scientific works is becoming more popular, but the bottleneck of such studies is the lack of consensus among researchers on the selection of detection techniques to be used, especially for novice researchers. It is a daunting task for any inexperienced researcher when they fail to identify the right tools needed for microalgal biofilm studies. In this review, a well‐refined analysis protocol about microalgal biofilm and EPSs were prepared including its extraction and characterization. Pros and cons of various detection techniques were addressed and cutting‐edge methods to study biofilm EPSs were highlighted. Future perspectives were also presented at the end of this review to bridge research gaps in studying biofilm adhesion via EPSs production. Ultimately, this review aims to assist novice researchers in making the right choices in their research studies on microalgal biofilms in accordance to the available technologies and needs.
Rational construction of controllable autoimmune diabetes model depicting clinical features

Through animal models, particularly non-obesity diabetes model (NOD), pathological understandings of human autoimmune diabetes have been gained. However, features of those mouse models and the human disease are not sufficiently analogous; it is therefore not unexpected that interventions based on the mouse data fail at an alarming rate in clinical settings. An improvised model that maximally resembles the real pathological course is highly desirable. Here we devised a ‘double-hit’ strategy, pancreas was first hit by chemical damage (streptozotocin, STZ) to unleash auto-antigens, then hit second time by transient immune-inflammation (regulatory T cell depletion). Comparing to NOD model, this strategy not only induced classical diabetic symptoms, but also depicted the crucial pathogenic features absent in conventional models, such as CD8+ T cell dominant infiltrates, strong ketoacidosis and epitope-specific T cell responses. In addition, this model allowed synchronized control of disease onset, permitting more refined temporal analysis of disease progression. We believe that this model would yield research outcomes with clinically relevant prediction power unattainable previously.
BoNT/A in the Urinary Bladder—More to the Story than Silencing of Cholinergic Nerves

Botulinum neurotoxin (BoNT/A) is an FDA and NICE approved second-line treatment for overactive bladder (OAB) in patients either not responsive or intolerant to anti-cholinergic drugs. BoNT/A acts to weaken muscle contraction by blocking release of the neurotransmitter acetyl choline (ACh) at neuromuscular junctions. However, this biological activity does not easily explain all the observed effects in clinical and non-clinical studies. There are also conflicting reports of expression of the BoNT/A protein receptor, SV2, and intracellular target protein, SNAP-25, in the urothelium and bladder. This review presents the current evidence of BoNT/A’s effect on bladder sensation, potential mechanisms by which it might exert these effects and discusses recent advances in understanding the action of BoNT in bladder tissue.
Safety and Efficacy of Matrix-Associated Autologous Chondrocyte Implantation With Spheroids for Patellofemoral or Tibiofemoral Defects: A 5-Year Follow-up of a Phase 2, Dose-Confirmation Trial

Background: Matrix-associated autologous chondrocyte implantation (ACI) is a well-established treatment for cartilage defects. High-level evidence at midterm follow-up is limited, especially for ACI using spheroids (spherical aggregates of ex vivo expanded human autologous chondrocytes and self-synthesized extracellular matrix). Purpose: To assess the safety and efficacy of 3-dimensional matrix-associated ACI using spheroids to treat medium to large cartilage defects on different locations in the knee joint (patella, trochlea, and femoral condyle) at 5-year follow-up. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 75 patients aged 18 to 50 years with medium to large (4-10 cm2), isolated, single cartilage defects, International Cartilage Repair Society grade 3 or 4, were randomized on a single-blind basis to treatment with ACI at 1 of 3 dose levels: 3 to 7, 10 to 30, or 40 to 70 spheroids/cm2 of defect size. Outcomes were assessed via changes from baseline Knee injury and Osteoarthritis Outcome Score (KOOS), International Knee Documentation Committee score, and modified Lysholm assessments at 1- and 5-year follow-up. Structural repair was evaluated using MOCART (magnetic resonance observation of cartilage repair tissue) score. Treatment-related adverse events were assessed up to 5 years for all patients. The overall KOOS at 12 months was assessed for superiority versus baseline in a 1-sample, 2-sided t test. Results: A total of 73 patients were treated: 24 in the low-dose group, 25 in the medium-dose group, and 24 in the high-dose group. The overall KOOS improved from 57.0 ± 15.2 at baseline to 73.4 ± 17.3 at 1-year follow-up (P < .0001) and 76.9 ± 19.3 at 5-year follow-up (P < .0001), independent of the applied dose. The different defect locations (patella, trochlea, and weightbearing part of the femoral condyles; P = .2216) and defect sizes (P = .8706) showed comparable clinical improvement. No differences between the various doses were observed. The overall treatment failure rate until 5 years was 4%. Most treatment-related adverse events occurred within the first 12 months after implantation, with the most frequent adverse reactions being joint effusion (n = 71), arthralgia (n = 14), and joint swelling (n = 9). Conclusion: ACI using spheroids was safe and effective for defect sizes up to 10 cm2 and showed maintenance of efficacy up to 5 years for all 3 doses that were investigated. Registration: NCT01225575 (ClinicalTrials.gov identifier); 2009-016816-20 (EudraCT number).
DFT Study of the Molecular and Electronic Structure of Metal-Free Tetrabenzoporphyrin and Its Metal Complexes with Zn, Cd, Al, Ga, In

The electronic and molecular structures of metal-free tetrabenzoporphyrin (H2TBP) and its complexes with zinc, cadmium, aluminum, gallium and indium were investigated by density functional theory (DFT) calculations with a def2-TZVP basis set. A geometrical structure of ZnTBP and CdTBP was found to possess D4h symmetry; AlClTBP, GaClTBP and InClTBP were non-planar complexes with C4v symmetry. The molecular structure of H2TBP belonged to the point symmetry group of D2h. According to the results of the natural bond orbital (NBO) analysis, the M-N bonds had a substantial ionic character in the cases of the Zn(II) and Cd(II) complexes, with a noticeably increased covalent contribution for Al(III), Ga(III) and In(III) complexes with an axial –Cl ligand. The lowest excited states were computed with the use of time-dependent density functional theory (TDDFT) calculations. The model electronic absorption spectra indicated a weak influence of the nature of the metal on the Q-band position.
Impacts of COVID-19 Regime on Labor Within Food Systems: Whither BRICS Now and Beyond?

The advent of COVID-19 has reconfigured foodscape across the globe, BRICS inclusive. Some of the familiar sites where people in BRICS found food in pre-pandemic period has become increasingly threatened while many have completely disappeared, leaving behind dark food deserts. Information on the extent of the devastation caused by the pandemic is still emerging. Such information is pivotal to the articulation of affirmative programs and policies. This article, therefore, explores the impact of the pandemic on food systems of BRICS to indicate how the alliance may positively influence the repositioning of each country member’s foodscape to achieve food security both now and beyond this pandemic. This article uses content analysis of relevant documents and draws from functionalist’s perspective to outline various impacts of the pandemic on food systems. It argues that creating enabling environment for labor, making food security a common goal of BRICS as a body as well as putting in place mechanisms supporting local food systems will invariably ensure food security across various levels in BRICS.
Correlation-Based Network Analysis of the Influence of Bemisia tabaci Feeding on Photosynthesis and Foliar Sugar and Starch Composition in Soybean

Simple Summary Bemisia tabaci affects plant performance by feeding directly from its energy sources, making it difficult to quantify crop damage, which is indirectly assessed through losses in productivity. The goal of this study was to characterize the influence of B. tabaci feeding on soybean, an economically valuable crop, and attempt to identify the optimal parameter for direct quantification of crop damage. A correlation network was created to extract biological interactions between the plant and B. tabaci nymphs at different densities and plant stages. Nymphs were more abundant during the vegetative stage, and a strong correlation between the density of nymphs and starch and fructose content was observed. The photosynthetic parameter turn-over number N was positively correlated with nymph density at a low-infestation level and negatively correlated with nymphs when they occur at a high infestation level. This association between nymph density and N may allow for development of a ranking scale to predict pest density, representing a useful tool for evaluating the potential impact of B. tabaci on soybean, especially in large areas, where nymph monitoring can be time-consuming. Abstract Bemisia tabaci (MEAM1) represents a species of economic importance in soybean. One of the obstacles to the management of B. tabaci is the quantification of damage by the pest because damage is indirectly inferred through losses in productivity. The objective of this study was to characterize the influence of B. tabaci feeding on soybean by assessing effects on photosynthetic parameters and the sugar and starch content of soybean leaves. The goal was to identify the optimal parameter to directly quantify pest damage on crop yield. Correlation networks were created among data on sugar content (fructose, glucose, and sucrose), starch and photosynthetic parameters (initial fluorescence, performance index on absorption basis, and turn-over number), and the number of nymphs at each of three infestations level (low, medium, and high) during both the vegetative and reproductive stage of the crop. In general, nymphs were more abundant during the vegetative stage. Starch content was strongly correlated with nymph density. A strong positive correlation was observed between fructose and nymph density during the vegetative stage. Among the photosynthetic parameters, the turn-over number N was positively correlated with nymph density at a low-infestation level and negatively correlated with nymphs when they occurred at a high-infestation level. B. tabaci feeding affected the plant’s physiology and its interaction is reflected in part by the relationships among photosynthetic parameters as well as the levels of sugars and starch. This understanding might be useful in developing better monitoring tools for pest management.
Spectrograms Fusion-based End-to-end Robust Automatic Speech Recognition

To improve the robustness of automatic speech recognition (ASR), speech enhancement (SE) is often used as a front-end noise-removal process. Although there is complemen-tarity between the mapping-based and the mask-based SE system, one of the SE systems has been conventionally used as the front-end of ASR. We propose a spectrogram fusion (SF)-based end-to-end (E2E) robust ASR system, in which the mapping-based and masking-based SE are used as the front-end simultaneously. We adopt SF to combine the advantages of mapping-based and masking-based SE systems. SF and ASR modules are connected in an E2E manner, and joint training is conducted to finetune the front-end and the back-end. We compared the performance of different front-ends after joint training. From the experiments using Aishell and PNL 100 Nonspeech Sounds datasets, we found that the fusion of two SEs are beneficial for ASR, especially under low signal-to-noise ratio, where a relative improvement of more than 7% is achieved.
Addressing Beliefs Surrounding Urban Sustainability: The Need for a Contextual Urban Model

While talking about practical advancement at city level, nearby administration is perhaps the main factor and can’t be avoided among the numerous significant angles; financial aspects, innovation, and climate, as metropolitan maintainability includes staggered administration and complex political elements. Utilizing the hypothesis of contextualism established by S. Pepper, this paper first and foremost considers the significance of ‘feasible’ and investigates the utilization and more extensive ramifications of the word ‘reasonable’ all through as conceived by contextualism. While featuring how metropolitan maintainability can be surveyed, this paper scrutinizes explicit strategies for evaluating metropolitan supportability. It endeavors to connect the basic way of thinking of contextualism to the idea of nearby administration as far as metropolitan administration. It then, at that point, investigates the disconnected part of these standards involving the city of Curitiba for instance. Anyway the model of the city of Curitiba demonstrated hard to survey, as there are excessively many variables to consider. It is felt that this contextual analysis is useful as a showing of the possible significance of the context oriented metropolitan model. We accept it impossible that this will be addressed soon, however it is critical to check out it and an answer for this logical inconsistency ought to be focused on.
Allium-Based Phytobiotic for Laying Hens’ Supplementation: Effects on Productivity, Egg Quality, and Fecal Microbiota

The poultry industry is constantly demanding novel strategies to improve the productivity and health status of hens, prioritizing those based on the holistic use of natural resources. This study aimed to assess the effects of an Allium-based phytobiotic on productivity, egg quality, and fecal microbiota of laying hens. One hundred and ninety-two 14-week-old Lohmann Lite LSL hens were allocated into an experimental farm, fed with a commercial concentrate with and without the Allium-based phytobiotic, and challenged against Salmonella. Productivity, egg quality, and fecal microbiota were monitored for 20 weeks. Results showed that the phytobiotic caused an increase on the number of eggs laid (p < 0.05) and in the feed conversion rate (p < 0.05); meanwhile, egg quality, expressed as egg weight, albumin height, haugh units, egg shell strength, and egg shell thickness remained unchanged (p > 0.05), although yolk color was decreased. Fecal microbiota structure was also modified, indicating a modulation of the gut microbiota by increasing the presence of Firmicutes and Bacteroidetes but reducing Proteobacteria and Actinobacteria phyla. Predicted changes in the functional profiles of fecal microbiota suggest alterations in metabolic activities that could be responsible for the improvement and maintenance of productivity and egg quality when the phytobiotic was supplemented; thus, Allium-based phytobiotic has a major impact on the performance of laying hens associated with a possible gut microbiota modulation.
The Relationship Between Self-care Behaviors with Religious Attitudes, Anxiety, and Depression in Patients with Heart Failure

Background and Aim: Heart failure is one of the major concerns and problems associated with anxiety and depression, which cause changes in self-care behaviors. This study aimed to investigate the relationship between self-care behaviours with religious attitudes, anxiety, and depression in patients with heart failure. Materials and Methods This descriptive cross-sectional study was performed in 114 patients selected by the quota sampling method. Data collection tools included a demographic information questionnaire, a European questionnaire of self-care behaviour in patients with heart failure, hospital anxiety, and depression questionnaire, and a religious attitude questionnaire. Data analysis was performed by using SPSS software and Pearson statistical tests, regression analysis, t-test, and ANOVA, and the significance level was considered p <0.05. Results The mean age of the participants was 55.47± 13.90 years. Hypertension (15.8%) and diabetes with hypertension (14%) were the most common underlying diseases in the participants. The mean self-care score of the patients was 38. 92±7.86 and was moderate. The mean scores of anxieties, depression and religious attitude were 9.83±4.22, 9.61±4.75and 69.05±10.08, respectively, and were moderate. There was also a significant relationship between self-care with anxiety and depression (p <0.05). Conclusion Self-care is directly related to anxiety and depression and the effect of anxiety is much greater than depression. Therefore, according to the results of the present study, if we could reduce the anxiety and stress of these patients with different methods, we can promote self-care and improve their health status.
AUTOMATED ARABIC ESSAY SCORING BASED ON HYBRID STEMMING WITH WORDNET

Schools, universities, and other educational institutions have been forced to close their doors because of the coronavirus outbreak. E-learning has become an option and has long been discussed about the need to integrate it into the educational process-learning uses a variety of evaluation methods, one of which is the essay. This research introduces a new model for Arabic Automated Essay Grading (AAEG) that has been developed to reduce human bias mistakes and costs while saving time. However, (AAEG) is still in its infancy. The model relies on new hybrid stemming with Arabic WordNet (AWN). The primary goal of stemming is reducing inflectional forms of words to root words. The hybrid method is based on different techniques: Extended Light Stemmer, ISRI, and looking at tables (AWN). Data used in this study consists of 3050 words with their roots were retrieved from (AWN) and then stemmed using algorithms (Light10, ISRI, Hybrid.). For evaluation, the metrics used were accuracy, precision, recall, and F1-score. While comparing the performance of the different stemming algorithms, the hybrid stemming method had the greatest results, therefore the (AAEG) will improve with Hybrid Stemming.
Effect of Blood Flow Restriction on Functional, Physiological and Structural Variables of Muscle in Patients with Chronic Pathologies: A Systematic Review

The main objective of this systematic review of the current literature is to analyze the changes that blood flow restriction (BFR) causes in subjects with neuro-musculoskeletal and/or systemic pathologies focusing on the following variables: strength, physiological changes, structural changes and cardiocirculatory variables. The search was carried out in seven databases, including randomized clinical trials in which therapeutic exercise was combined with the blood flow restriction tool in populations with musculoskeletal pathologies. Outcome variables are strength, structural changes, physiological changes and cardiocirculatory variables. Twenty studies were included in the present study. Although there is a lot of heterogeneity between the interventions and evaluation instruments, we observed how the restriction of blood flow presents significant differences in the vast majority of the variables analyzed. In addition, we observed how BFR can become a supplement that provides benefits when performed with low intensity, similar to those obtained through high-intensity muscular efforts. The application of the BFR technique can provide benefits in the short and medium term to increase strength, muscle thickness and cardiovascular endurance, even improving the physiological level of the cardiovascular system. In addition, BFR combined with low-load exercises also achieves benefits comparable to high-intensity exercises without the application of BFR, benefiting patients who are unable to lift high loads.