Miracle-dz/UniFAR-FTUs huggingface dataset:
Microrna-2392 Functions as a Tumor Suppressor Gene and Inhibits Malignant Progression of Hepatocellular Carcinoma Via Directly Targeting JAG2

Background Dysregulation of microRNA (miRNA) expression in various cancers and their vital roles in malignant progression of cancers are well investigated. Our previous studies have analyzed miRNAs that promote malignant progression of hepatocellular carcinoma (HCC), this study aim to systematically elucidate metastasis suppressor miRNAs in HCC. Results miR-2392 was significantly down-regulated in HCC. Overexpression of miR-2392 suppressed proliferation, mobility, spheroid formation and maintenance of cancer stem cells (CSC)-like characteristics in HCC cell lines, whereas down-regulation of miR-2392 led to the opposite results. CTCs from HCC patients with lower serum miR-2392 level had stronger cell spheroid formation ability. A negative correlation between the content of miR-2392 in serum and the number of CTC spheroids had been found. We identified Jagged2 (JAG2) as a direct target of miR-2392, miR-2392 inhibited the expression and nuclear accumulation of JAG2 by targeting 3’-UTR of JAG2. HCC cells were treated with LV-miR-2392 inhibitor and JAG2-siRNA to explore the mechanism of miR-2392 and JAG2 on HCC. Down-regulation of JAG2 inhibited the overexpression effects of miR-2392 in vitro and in vivo. JAG2 is highly expressed in HCC and is closely related to poor prognosis and survival of patients. Conclusions Our findings indicated a significant role of the miR-2392/JAG2 axis in suppressing HCC cell growth and aggressiveness, miR-2392 may play a role as a tumor suppressor gene to guide the individualized precise treatment of HCC.
Polygyny and Farm Households' Resilience to Climate Shocks

Climate change and weather shocks pose major challenges for household income security and well-being, especially for smallholder farmers’ communities. In such communities, imperfect risk insurance and labor markets may induce households to use traditional institutions such as polygyny to harness their size and composition to their resilience strategies against these shocks. This paper tests this hypothesis by analyzing how polygyny’s interaction with droughts affects crop yields. For identification, the paper relies on the spatial variation in polygyny’s prevalence across Mali’s rural communes and the randomness of drought episodes. The findings show that polygynous communities are more resilient to drought-induced crop failure. Exploration of the mechanisms shows that polygynous communities diversify their income sources more than monogamous ones, including via child marriage—a phenomenon known to undermine women’s outcomes. As the literature links polygyny to underdevelopment, interventions to eliminate it should make formal resilience and adaptation strategies available to drought-prone communities. Failure to do so may entrench political opposition to enforcing a ban on polygyny and child marriage.
Missing marriage: changing marriage patterns amid social transition in Myanmar

ABSTRACT Across Asia, men and women increasingly delay or abstain from marriage, a change often linked to improvements in female educational attainment and labour force participation. In Myanmar, less than 90 per cent of women aged 45–49 years during the 2014 census had ever married, compared to nearly all men of a similar age. This paper investigates the difference in marriage patterns between males and females in Myanmar. Using a Cox proportional hazards model, we analyse the associations between entry into marriage across age cohorts, and male and female educational attainment and workforce participation. We find that having a high level of education and currently working negatively affect women's chances of marrying across all ages. While higher education similarly affects younger men, we find that higher socioeconomic status substantially improves a man's likelihood of marriage in later life, suggesting lingering gender stereotypes influencing women to remain single in the country.
Mature Diffuse Tectonic Block Boundary Revealed by the 2020 Southwestern Puerto Rico Seismic Sequence

Distributed faulting typically tends to coalesce into one or a few faults with repeated deformation. The progression of clustered medium‐sized (≥Mw4.5) earthquakes during the 2020 seismic sequence in southwestern Puerto Rico (SWPR), modeling shoreline subsidence from InSAR, and sub‐seafloor mapping by high‐resolution seismic reflection profiles, suggest that the 2020 SWPR seismic sequence was distributed across several short intersecting strike‐slip and normal faults beneath the insular shelf and upper slope of Guayanilla submarine canyon. Multibeam bathymetry map of the seafloor shows significant erosion and retreat of the shelf edge in the area of seismic activity as well as slope‐parallel lineaments and submarine canyon meanders that typically develop over geological time. The T‐axis of the moderate earthquakes further matches the extension direction previously measured on post early Pliocene (∼>3 Ma) faults. We conclude that although similar deformation has likely taken place in this area during recent geologic time, it does not appear to have coalesced during this time. The deformation may represent the southernmost part of a diffuse boundary, the Western Puerto Rico Deformation Boundary, which accommodates differential movement between the Puerto Rico and Hispaniola arc blocks. This differential movement is possibly driven by the differential seismic coupling along the Puerto Rico—Hispaniola subduction zone. We propose that the compositional heterogeneity across the island arc retards the process of focusing the deformation into a single fault. Given the evidence presented here, we should not expect a single large event in this area but similar diffuse sequences in the future.
Numerical simulation of transport phenomena in a bacteria trapping device

In the past two decades, microfluidic devices have been widely improved and developed in a variety of chemical and biological applications, such as crystallization, micro/nano-particle synthesis, polymer engineering, immunology and clinical diagnosis. This project focussed on a new microdevice for application in the biology field, to aid in experimental studies of bacteria growth. The device aims at trapping bacteria in a confined space, continuous supply of nutrients and removal of metabolic products, growth of bacteria in monolayer and easy observation of bacteria metabolic responses to medium changes. For its fabrication, the selection of the optimal parameters should be carefully pondered according to the experimental limitations, e.g. pressure drop/flow rate limits of the micropump, precision of the available manufacturing methods and biological requirements of bacteria motion in a confined channel. In this project, computational fluid dynamics (CFD) was used to investigate the parameters affecting motion and trapping of bacteria in the device, as well as the conditions that promote a better nutrient distribution. A 2D numerical computation model was developed and validated against literature data. The results indicate that bacteria trapping is enhanced by narrower feed channel, shorter microchannels, longer devices and higher ratio between the average velocities of the feed and waste inlet streams. They also show that changes in the inlet average velocity of the feed channel and in the microchannel density does not produce a significant effect on bacteria trapping.
5G network slicing: Fundamental concepts, architectures, algorithmics, projects practices, and open issues

Network slicing (NS) presents the key enabler of cellular network improvements. It allows enhancing the performance of diverse requirements supported for verticals industries. The concept of NS was carefully studied over the previous few years, and the primary operational principles were developed. However, there is an important need for more investigations on studying NS to enable further development. This article offers a deep study related to the NS principle, the recent standardization process for Third Generation Partnership Project and Fifth Generation Public Private Partnership, the diverse broad use cases, NS key concepts, NS architectures, and NS management and orchestration. Besides, it discusses radio access network slicing and sharing, the algorithms, the projects, and the NS practical experience and practices. Finally, this article proposes and highlights a possible solution to several open research issues.
Adsorption of Azo-Anionic Dyes in a Solution Using Modified Coconut (Cocos nucifera) Mesocarp: Kinetic and Equilibrium Study

The effect of adsorbent dose and initial concentration on removing the azo-anionic dyes Congo Red andtartrazine present in a synthetic aqueous solution was studied using natural cellulose (CC) and modified cationic cellulose (MCC) from coconut mesocarp. Three levels of adsorbent dosage (5, 8 and 12 mg/L) and initial concentration (40, 70 and 100 mg/L) were used. Cetyl trimethyl ammonium chloride (CTAC) was used as a modifying agent. TGA and DSC showed that the extracted cellulose was of good quality, composed mostly of cellulose with lignin and hemicellulose traces, and 8% moisture. The FTIR spectrum showed the effectiveness of the modification in the structure of the material with symmetric deformation of the C6H6-Cl group in 1472 cm−1 present in the CTAC. It was found that decreasing the adsorbent dosage and increasing the initial concentration favored the dyes’ adsorption capacity on the two bioadsorbents. Tartrazine removals of 5.67 mg/g on CC and 19.61 mg/g on MCC were achieved, and for CR of 15.52 mg/g on CC and 19.99 with MCC with removal percentages over 97% with the quaternized biomass in all cases. The kinetic and equilibrium study was carried out to identify the mechanisms involved in the adsorption process. The Freundlich model can describe the equilibrium isotherm data of tartrazine on CC and MCC. In contrast, those of CR is defined by the Langmuir and Dubinin–Radushkevic models for CC and MCC, respectively Adsorption kinetics showed that equilibrium was reached at 30 min, with rapid adsorption in the initial minutes with the removal of about 97% of the contaminant in the first 5 min; fitting to kinetic models showed that the kinetics of tartrazine on CC was fitted by Elovich (R2 = 0.756), and on MCC the Elovich (R2 = 0.887) and pseudo-second-order (R2 = 0.999) models. Removing CR on CC was fitted by pseudo-first-order, pseudo-second-order and Elovich models (R2 > 0.98), and when using MCC, all models show a good fitting with R2 = 0.99 in all cases.
Oxidovanadium(V) Complexes Anchored on Carbon Materials as Catalysts for the Oxidation of 1‐Phenylethanol

Six oxidovanadium(V) aroylhydrazone complexes derived from (3,5‐di‐tert‐butyl‐2‐hydroxybenzylidene)‐2‐hydroxybenzohydrazide (H2L1) and (3,5‐di‐tert‐butyl‐2‐hydroxybenzylidene)‐2‐aminobenzohydrazide (H2L2), namely, [VOL1(OEt)][VOL1(OEt) (EtOH)] (1), [VOL2(OEt)] (2), [Et3NH][VO2L1] (3), [VO2(HL2)]⋅2 EtOH (4), [(VOL1)2(μ‐O)] (5), and [(VOL2)2(μ‐O)] (6), were synthesized and characterized by elemental analysis, IR, 1H NMR, and 51V NMR spectroscopies, ESI‐MS and, for 1–5, single‐crystal XRD. The compounds have VO3+ (1 and 2), VO2+ (3 and 4), and V2O34+ (5 and 6) cores. They are active homogeneous catalysts in the microwave‐assisted, solvent‐free peroxidative oxidation of 1‐phenylethanol to acetophenone by tBuOOH. The immobilization of the oxidovanadium complexes (1, 2, 4, and 5) on oxidized carbon materials improved the oxidation efficiency and allowed catalyst reuse with the preservation of activity.
Contemporary analysis of small and medium business failure in Sri Lanka

Small and Medium Enterprises (SME) businesses are most important for Sri Lanka because they make large contribution for the national economy of the country. SME contribute 45% of national income and 52% of total Gross Domestic Product (G.D.P) in Sri Lanka. SMEs represent the 80% of all businesses in Sri Lanka. As a source of employment SMEs contribute 35% of employment of Sri Lanka. According to the statistics of the industry , SMEs are engaged to the different business in the country such as manufacturing, trading, mining, education, apparel, tourism support services, export and imports, agriculture and different other sectors. In Sri Lanka village based and city-based SMEs are operating around the country. due to the higher value of the SMEs, recent researchers have paid attention on the SME development and related problems of them. With the recent globalization trends and complex economic scenarios, SMEs have to face to the different kind of failures.
Stress Testing MQTT Server for Private IOT Networks

The rapid development of the Internet of Things (IoT) and the wide area of application rise the IoT concept to be the future of the internet. Indeed, IoT environment has a special nature with a lot of constraints in term of resource consumption. Moreover, the data exchanged between things and the internet is big data. In order to achieve efficiency in IoT communication, many technologies and new protocols based on these technologies have been developed. This paper aims to study the performance of Message Queuing Telemetry Transport (MQTT) by implementing this protocol on test-bed network infrastructure and analyzing the performance properties such as delay jitter, packet loss and throughput for real time and non-real time scenarios. Finally, future research issues in MQTT protocol are suggested.
Enhancing the smart building supervisory system effectiveness

ABSTRACT Modern buildings are managed by the BMS (Building Management System), a supervisory system that controls its mechanical and electrical devices. The automatic detection of faults and malfunctions plays a crucial role in the monitoring and control processes of electrical devices located in a smart building. The integration of this functionality within a BMS allows to improve the consistency and the effectiveness of the control network and to recognize and report in real-time the system’s malfunctioning. The research focuses on the definition of Fault Detection procedures to verify the successful implementation of sequential commands given by control and supervisory system. The authors realize a tool to control and manage in real-time the data coming from the sensors to verify the effective implementation of a command. The procedure is based on the following important assumption – we must be able to associate the trend of a given reference magnitude with each command. By monitoring the magnitude’s status and comparing them with default threshold values, the algorithms determine the command execution. Authors apply the proposed strategies on the F40 building, located in the ENEA R.C. ‘La Casaccia’, to detect faults and anomalies that can be traced to probable cyber intrusion or devices malfunctioning.
Batería de Evaluación de Cognición Social en Psicología Forense: Adaptación y Validación

Assessment Battery for Social Cognition in Forensic Psychology: Adaptation and Validation The aim of the study was to adapt and validate a battery for the evaluation of subdomains of social cognition with the forensic population in Colombia and Mexico from a selection of instruments used in clinical neuropsychology. We reviewed the relevance of the subdomains that compose social cognition as evidence of content validity through the assessment of different psychologists, experts in forensic psychology, neuropsychology and measurement and evaluation, using the modified ANGOFF method and a reliability analysis according to the Rasch model and Cronbach's Alpha coefficient. Subsequently, a pilot study was performed with 20 people deprived of liberty in Colombian and Mexican prisons. INFIT calibrations of 1.17 and 1.04, and OUTFIT calibrations of 1.08 and 1.18, with separation rates of 2.66 and 1.63, and reliability of . 88 and . 73 were found in Colombians and Mexicans respectively; these data provide evidence of the validity of the adapted battery.
Evaluation of cooking time and organoleptic traits of improved Dolichos (Lablab purpureus (L.) sweet) genotypes

In Lablab bean, cooking time and organoleptic qualities are major factors that influence its adoption and consumption. Its production in Kenya has been constrained by low yielding varieties, pests, poor agronomy and varieties with non-preferred taste and flavor. This study was initiated to evaluate cooking time and organoleptic traits of six Dolichos genotypes, (G2, B1, M5, LG1, W7 and G2), that had been bred at the University of Eldoret and two checks (Local Variety and DL1002). Cooking time and organoleptic studies were carried out on-farm in Meru County, Ruiri sub location using an organized farmer group (Ruiri farmers group) that comprised of ten panelists (seven women and three men). There was a high significant difference (P ≤ 0.001) among the six improved genotypes and the two checks in terms of cooking time and sensory attributes evaluated. Cooking time ranged from 87 to 159 min, with genotype M5 taking the shortest time (87 min) and local variety taking the longest time (159 min) to cook, respectively. In overall acceptability, genotypes G2, G1, M5 and B1 were highly rated because of their short cooking time and good organoleptic attributes. High variability among the genotypes evaluated could be exploited even further in breeding programs to produce genotypes that take even less time to cook and with even better organoleptic characters for easy adoption by farmers. Key words: Lablab (Lablab purpureus), cooking time, organoleptic traits.
Static Characteristics and Leakage Rates of Smooth Annular Seals Based on a New Solution Method for Gas-Liquid Two-Phase Conditions

This paper proposes a new solution method for the leakage and static characteristics of smooth annular seal under a homogeneous gas-liquid two-phase flow based on a bulk-flow model. In this solution method, the Rayleigh–Plesset equation is introduced into the governing equations to describe the behavior of bubbles considering mixture compressibility. Detailed comparisons between Childs’ experimental leakage rates and predicted ones based on the proposed method are conducted, and the predicted results show good agreement with the experimental results, with a maximum error of 11.2%. Moreover, static characteristics of the seal, including leakage rates, gas volume fraction (GVF) distribution, pressure distribution, mixture density, and viscosity within the seals, are investigated based on the present method. The results show that as the inlet gas volume fraction increases from 0% to 10%, the local gas volume fraction of each axial position will increase, however, the seal leakage, mixture density, and mixture viscosity will decrease. Bubble radius has little effect on the leakage rates and the static characteristics of the seals. Additionally, comparisons between the characteristics of the model seals with different clearances show that the leakages of the seals with bigger clearance behave more sensitively to the inlet GVF changes.
Hand-Drawn Sketch Recognition With Double-Channel CNN

In the task of hand-drawn sketch recognition, traditional deep learning methods have the insufficient of feature extraction and low recognition rate. To improve the insufficient, a novel algorithm based on double channel convolution neural network is proposed. First of all, the hand-drawn sketch is preprocessed to get a smooth sketch. And the contour extraction algorithm is adopted to get the contour of the sketch. The sketch and its contour are then used as input images of the CNN respectively. Finally, through performing feature fusion at the full connection layer, the classification results are obtained using the softmax classifier. The experimental results show that the proposed method can effectively improve the recognition rate of hand-drawn sketch.
Agreement Between Physician Evaluation and the Composite Response Index in Diffuse Cutaneous Systemic Sclerosis

Diffuse cutaneous systemic sclerosis (SSc) is a highly heterogeneous disease. A provisionally approved Composite Response Index in diffuse cutaneous SSc (CRISS) was developed as a 1‐year outcome measure for clinical trials. Our goal was to further validate the CRISS by examining agreement between CRISS definitions for improved/non‐improved with physicians' evaluation of disease.
Teaching Friendship Skills to Adolescents with Autism Spectrum Disorder: Current Situation and Lessons

Difficulty in communication and social interaction has certain impacts on the skills of making friends and building friendships among adolescents with autistic spectrum disorder (ASD). This study focusing on the current status of teaching friendship skills to adolescents with ASD among 125 teachers and 101 parents found that (i) adolescents with ASD mostly struggle with making new friends, participating in group activities, and helping others; (ii) teachers and parents encounter difficulties in selecting the contents, approaches and methods to teach adolescents with ASD to make friends; and (iii) there is a lack of resources that provide teachers and parents with teaching activities and methodology to effectively support adolescents with ASD to make friends.
Improvements of antimicrobial and barrier properties of waterborne polyurethane containing hydroxyapatite-silver nanoparticles

Abstract Three series of waterborne polyurethane (WBPU)/hydroxyapatite (HA) nanocomposite dispersions were prepared with varying HA and 2,2-dimethylol propionic acid (DMPA) content. It was found that the homogeneous distributed HA was highly dependent on the HA and DMPA content, with homogeneous HA found with up to 0.56, 0.95, and 1.33 mol% HA content with respect to 17.03, 22.05, and 24.02 mol% DMPA content, respectively. The hydrogen bonding increased with increased HA content in each series. The tensile strength, Young’s modulus, glass transition temperature, and water vapor permeability (WVP) resistance all increased up to the optimum HA content. The maximum tensile strength, Young’s modulus, glass transition temperature, and WVP resistance were found with 1.33 mol% HA and 24.02 mol% DMPA content, the concentrations at which the maximum homogeneous dispersed HA was observed in the WBPU/HA nanocomposites. A strong antibacterial property was also recorded when 1.33 mol% HA and 24.02 mol% DMPA content in hydroxyapatite-silver polyurethane (WBPU-C/HA3-Ag) coatings were tested against Escherichia coli and Staphylococcus aureus.
Kovid 19 ile İlgili Gelişmeleri Kaçırma Korkusu Ölçeğinin Geliştirilmesi: Geçerlik ve Güvenirlik Çalışması

The purpose of this research is to develop a scale on the fear of missing out on developments related to Covid 19, which is one of the most important agenda items in the world nowadays. For this purpose, Explanatory Factor Analysis (EFA) was performed on data collected from 397 people and Confirmatory Factor Analysis (CFA) was performed on data collected from 346 people. As a result of EFA, five items, one-dimensional structure which explains 47,867% of the total variance was obtained. Subsequently, according to the DFA result, the structure obtained in EFA was confirmed. In addition, measurement invariances of the scale obtained according to gender and marital status were examined. While only strict invariance could not be achieved in gender, all types of invariance in marital status were provided. Within the scope of the criterion validity, a moderate, positive relationship was found between the fear of missing out related to Covid 19 (FoMOC 19) and the fear of missing out (FoMO) and the fear of Covid 19. FoMOC 19 had low-level significant positive relationship with social media addiction and internet addiction; but there was a significant negative, low relationship with psychological resilience. Regarding reliability, Cronbach's Alpha and Mcdonald's ω values were found to be above . 70 on both EFA and CFA data. Discussions were held within the scope of the results obtained, limitations and recommendations were mentioned.