Miracle-dz/UniFAR-FTUs huggingface dataset:
Prostate cancer risk associated Single Nucleotide Polymorphism affects PSA glycosylation and its function

BACKGROUND: Genetic association studies have reported single nucleotide polymorphisms (SNPs) at Chromosome 19q13.3 to be associated with prostate cancer (PCa) risk. Recently, the Correspondence should be addressed to: A/Prof Jyotsna Batra, Australian Prostate Cancer CentreQueensland, Translational Research Institute, Queensland University of Technology, Woolloongabba, Queensland, Australia 4102. Phone: +61 7 3443 7336, Fax: +61 7 3138 6030, jyotsna.batra@qut.edu. au. Authors Contributions S.S. performed most of the assays (cell-based assays with PSA overexpressing PC3, activity and stability assays using recombinant PSA and F/T PSA analysis) and drafted the manuscript. CS performed recombinant PSA expression along with SS. EW and AB performed the MD analysis. JP helped in experimental analysis. KD performed free/total PSA testing for recombinant PSA variants. HK and US performed endothelial cell assays with recombinant PSA and IGFBP3 assay. The PRACTICAL consortium provided SNP data. RK and HL contributed genotyping and biomarker data, and have mentored and provided ideas on some aspects such as immunoassay and manuscript editing. JC and JB conceived and supervised the project and edited the manuscript. †members from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium are provided in the Supplemental file. Information of the consortium can be found at http://practical.icr. ac.uk/. ‡these authors jointly directed this work. Previous presentation of the manuscript The manuscript has not been submitted to any other journal. Disclosure HL holds patents for free PSA, hK2, and intact PSA assays, and is named on a patent for a statistical method to detect prostate cancer. The marker assay patents and the patent for the statistical model has been licensed and commercialized as the 4Kscore by OPKO Diagnostics. HL receives royalties from sales of this test, and owns stock in OPKO. HHS Public Access Author manuscript Clin Chem. Author manuscript; available in PMC 2020 January 01. Published in final edited form as: Clin Chem. 2019 January ; 65(1): e1–e9. doi:10.1373/clinchem.2018. 295790. A uhor M anscript
What Have We Learned from Studies of IFN-l Variants and Hepatitis C Virus Infection?

Chronic infection with the hepatitis C virus (HCV) is a major cause of cirrhosis and hepatocellular carcinoma. In 2009, genome-wide association studies (GWAS) strongly linked genetic variants in the interferon lambda (IFN-l) chromosomal region to HCV clearance. In 2013, discovery of the IFNL4 gene provided a functional explanation for those GWAS findings. The IFNL4-DG/TT (rs368234815) variant controls generation of the IFN-l4 protein. Paradoxically, the IFNL4-TT allele, which abrogates IFN-l4, associates with higher rates of spontaneous HCV clearance and better response to treatments for HCV infection. The finding that a ‘‘knockout’’ allele for IFN-l4 enhances HCV clearance challenges the paradigm of IFNs as antiviral cytokines. Genetic variants in the IFN-l region have also been associated with hepatic inflammation and fibrosis from various etiologies, however, alleles that are linked with improved HCV clearance associates with worse inflammation and fibrosis. These studies demonstrate that GWAS of infectious diseases may yield important and unexpected biological insights.
Dichotomies in Digital Mental Health

Unstructured Abstract: The uptake and clinical adoption of digital mental health tools like smartphone apps remain limited. While some technology barriers remain, the greatest challenges are no longer technical but rather the dichotomous directions and efforts dividing the space and limiting its potential. This paper focuses on six of these dichotomies including randomized versus pragmatic studies, precision versus population health, free market versus regulation, consumer versus clinical uses, big data versus privacy, open versus proprietary software. Realizing that there is no panacea, the authors suggest a more flexible approach towards digital mental health which offers a pragmatic solution to better appreciate the landscape and pave the way towards progress.
PREVALENCE OF ACANTHOSIS NIGRICANS

Acanthosis nigricans (AN) is characterized by dark, coarse and thickened skin with a velvety texture, being symmetrically distributed on the neck, the axillae, antecubital and popliteal fossae, and groin folds, histopathologically characterized by papillomatosis and hyperkeratosis of the skin. A high prevalence of AN has been observed recently. Different varieties of AN include benign, obesity associated, syndromic, malignant, acral, unilateral, medication-induced and mixed AN. Diagnosis is largely clinical with histopathology needed only for confi rmation. Other investigations needed are fasting lipoprotein profi le, fasting glucose, fasting insulin, hemoglobin and alanine aminotransferase for obesity associated AN and radiological investigations (plain radiography, ultrasonography, magnetic resonance imaging/computerized tomography) for malignancy associated AN. The most common treatment modalities include retinoids and metformin.
Potential Roles of Total Body PET/CT in Pediatric Imaging

Total-Body (TB) PET/computed tomography (CT) provides a substantial gain in the physical sensitivity of PET, leading to vastly improved image quality or can enable imaging applications that are either not possible with conventional PET or suffer from poor signal-to-noise. The paradigm-shifting promise of TB-PET/CT lies in its capability to perform dynamic, delayed, and low-dose imaging, which have the potential to increase the range of diseases and disorders that can be investigated or managed using PET. Here we discuss the use of TB-PET/CT and describe protocols that take advantages of this unique innovation applied to the needs of the pediatric population.
BJRD15680 1..7

1HUSEYIN TOPRAK, MD, 1HUSEYIN YETIS, MD, 1ALPAY ALKAN, MD, 2MEKIYA FILIZ, PhD, 1SERPIL KURTCAN, MD, 1AYŞE ARALASMAK, MD, 3MEHMET Ş AKSU, MD and 3YAŞAR CESUR, MD Department of Radiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey Department of Child Psychology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey Department of Pediatric Endocrinology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
Impaired h-c Coupling Indicates Inhibitory Dysfunction and Seizure Risk in a Dravet Syndrome Mouse Model

Nico A. Jansen,1 Carlos Perez,2 Maarten Schenke,1 Anouk W. van Beurden,1 Anisa Dehghani,1 Rob A. Voskuyl,1 Roland D. Thijs,3,4 Ghanim Ullah,2 Arn M.J.M. van den Maagdenberg,1,3p and Else A. Tolner1,3p Department of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands, Department of Physics, University of South Florida, Tampa, Florida 33620, Department of Neurology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands, and Stichting Epilepsie Instellingen Nederland, 2103 SW Heemstede, The Netherlands
Human Interphase Nuclei

A total of 1,000 lymphocyte interphase nuclei per proband from 90 females and 138 males age 1 wk to 93 years were analyzed by in situ hybridization for loss of the X and Y chromosomes, respectively. Both sex chromosomes showed an age-dependent loss. In males, Y hypoploidy was very low up to age 15 years (0.05%) but continuously increased to a frequency of 1.34% in men age 76-80 years. In females, the baseline level for X chromosome loss is much higher than that seen for the Y chromosome in males. Even prepubertal females show a rate of X chromosome loss, on the order of 1.5%-2.5%, rising to -4.5%-5% in women older than 75 years. Dividing the female probands into three biological age groups on the basis of sex hormone function (<13 years, 13-51 years, and >51 years), a significant correlation of X chromosome loss versus age could clearly be demonstrated in women beyond age 51 years. Females age 51-91 years showed monosomy X at a rate from 3.2% to 5.1%. In contrast to sex chromosomal loss, the frequency of autosomal monosomies does not change during the course of aging: Chromosome 1 and chromosome 17 monosomic cells were found with a constant incidence of 1.2% and 1%, respectively. These data also indicate that autosome loss in interphase nuclei is not a function of chromosome size.
The Landscape of Genome-Wide and Gender-Specific Microsatellites in Indo-Pacific Humpback Dolphin and Potential Applications in Cetacean Resource Investigation

Microsatellites are one of the important genome characterizations that can be a valuable resource for variety identification, genetic diversity, phylogenetic analysis, as well as comparative and conservation genomics research. Here, we developed comprehensive microsatellites through genome-wide mining for the threatened cetacean Indo-Pacific humpback dolphin (Sousa chinensis). We found 87,757 microsatellites with 2–6 bp nucleotide motifs, showing that about 32.5 microsatellites per megabase comprises microsatellites sequences. Approximately 97.8% of the markers developed in this study were consistent with the published identified markers. About 75.3% microsatellites were with dinucleotide motifs, followed by tetranucleotide motifs (17.4%), sharing the same composition pattern as other cetaceans. The microsatellites were not evenly distributed in the S. chinensis genome, mainly in non-coding regions, with only about 0.5% of the markers located in coding regions. The microsatellite-containing genes were mainly functionally enriched in the methylation process, probably demonstrating the potential impacts of microsatellites on biological functions. Polymorphic microsatellites were developed between different genders of S. chinensis, which was expected to lay the foundation for genetic diversity investigation in cetaceans. The specific markers for a male Indo-Pacific humpback dolphin will provide comprehensive and representative male candidate markers for sex identification, providing a potential biomolecular tool for further analysis of population structure and social behavior of wild populations, population trend evaluation, and species conservation management.
Observer design for state and clinker hardness estimation in cement mill

This paper addresses a solution to state and clinker hardness estimation in industrial cement mill process. A Takagi-Sugeno model with unmeasurable premise variables is developed for the nonlinear model of a cement mill. Bsed on this model, a nonlinear observer is proposed in order to estimate the state variables and also the clinker hardness, which is an unknown input of the process. The convergence of the estimation error is studied using the Lyapunov theory and the input-to-state stability (ISS) approach. An optimization problem with LMI constraints is then provided for the synthesis of this observer. Finally, simulation results and some discussions about the robustness of the observer are given.
Fuzzy Equalization Strategy Based on Multilayer Circuits

In this study, the influence of the external current and the equalization current on the working current of the lithium battery during the equalization process is fully analyzed, a fuzzy equalization approach based on a multilayer circuit is proposed, with external current and the battery's SOC as inputs, and fuzzy rules to output a suitable equalization current to keep the battery's operating current within the permitted range. It is verified by simulation that the proposed fuzzy control strategy can limit the operating current of the lithium battery within the range of [-3A-3A], and the maximum operating current of the battery is reduced by 50% compared with the unbalanced strategy. It can ensure the safety in the process of battery balancing.
Over GHz bandwidth SAW filter based on 32° Y-X LN/SiO2/poly-Si/Si heterostructure with multilayer electrode modulation

Enhancing the central frequency ( fc) and bandwidth (BW) and reducing insertion loss (IL) are essential steps in surface acoustic wave (SAW) filter applications in the 5G era. With this in mind, we construct a 32° Y-X LiNbO3(300 nm)/SiO2(300 nm)/poly-Si(1 μm)/Si heterostructure to avoid both acoustic leakage through the waveguide effect and electrical loss through the introduction of a poly-Si layer. By separately modulating the electrode thicknesses of series and parallel resonators, the spurious modes can be mitigated out of the filter passband, preventing them from negatively impacting the filter characteristics. Moreover, to reduce Ohmic loss, an optimized design for an Al/Cu/Ti multilayer electrode is proposed as a replacement for the Cu/Ti electrode resonators built on Al/Cu/Ti electrodes provide a high resonance frequency of 3.76 GHz, a large electromechanical coupling coefficient of 23%, and a maximum quality factor of 1510 (twice that of the Cu/Ti electrodes). Finally, SAW filters with an fc of 3728 MHz and a 3-dB BW of 1052 MHz are implemented, with IL of 0.92 dB. The achieved specifications demonstrates that one-chip SAW filter is expected to become n77 band filtering solution.
Prediction of Mortality in Acute Thermal Burn Patients Using the Abbreviated Burn Severity Index Score: A Single-Center Experience

Background Burn injuries are highly variable and dynamic. The outcome of patients is influenced by various factors and requires prompt therapeutic interventions, including fluid resuscitation, for a favorable result. Although having varying shortcomings, many scoring indexes are developed and validated in Western countries to predict mortality in a burn patient. The Abbreviated Burn Severity Index (ABSI) estimates survival expectancy in a burn patient via various negative prognostic factors. This study describes the pattern of burn injuries to validate the ABSI as an outcome predictor in burnt patients. Methodology From January to December 2018, 100 patients participated in this observational research conducted in the Department of Surgery at Mahatma Gandhi Hospital’s Burn Ward, a part of Dr. Sampurnanand Medical College, Jodhpur. Risk factors for death from a burn were patients’ age and gender, the depth of the burn, the inhalation burn, and the total burned body surface area (TBSA). The area under the receiver operating curve (AUROC) was used to determine how well it could predict burn deaths. Results This study included 100 patients (69 men and 31 women, with a ratio of 2.22:1). In total, 73 patients survived, and 27 died (a mortality rate of 27%). The fatality rate increased with increased burn surface area, reaching 100% in patients with >80% burns (p < 0.0001). Additionally, those with an ABSI of >11 expressed 100% mortality rate (p < 0.0001). Conclusions In this study, older age, high burned surface area, concomitant inhalational burns, full-thickness burns, and a higher ABSI were found to be significant predictors of mortality.
Research Hotspots and Effectiveness of Transcranial Magnetic Stimulation in Pain: A Bibliometric Analysis

Transcranial magnetic stimulation, as a relatively new type of treatment, is a safe and non-invasive method for pain therapy. Here, we used CiteSpace software to visually analyze 440 studies concerning transcranial magnetic stimulation in pain research from 2010 to 2021, indexed by Web of Science, to clarify the research hotspots in different periods and characterize the process of discovery in this field. The United States ranked first in this field. Lefaucheur JP, Fregni F, and Andrade ACD made great contributions to this field of study. The most prolific institution was University of São Paulo. The four main hot keywords were neuropathic pain, motor cortex, connectivity, and non-invasive brain stimulation. There were three main points that were generally accepted: (1) definite analgesic effect of high-frequency rTMS of M1 contralateral to pain side in neuropathic pain; (2) there are inconclusive recommendations regarding rTMS of the dorsolateral prefrontal cortex (DLPFC) in fibromyalgia and neuropathic pain; (3) there is low-quality evidence that single doses of high-frequency rTMS of the motor cortex may have short-term effects on chronic pain. This bibliometric analysis indicated that prospective, multi-center, large-sample, randomized controlled trials are still needed to further verify the effectiveness of various transcranial magnetic stimulation parameters in pain research.
Kukoamine A Improves Mycoplasma pneumoniae Pneumonia by Regulating miR-222-3p/Superoxide Dismutase 2

Mycoplasma pneumoniae pneumonia (MPP) represents a common respiratory disease in children patients. Kukoamine A (KuA) is a spermine alkaloid found in the Chinese herb Cortex Lycii radices, which has a variety of pharmacological properties. However, no study has been reported on the role of KuA in MPP. Exosomes, a type of lipid bilayer-enclosed extracellular vesicles, can be delivered to the target cells, where they regulate function and physiology. With the use of human alveolar basal epithelial cells (HABECs) as an in vitro model, in this study, we sought to characterize the changes in levels of superoxide dismutase 2 (SOD2) and proinflammatory cytokines including IL-6 and TNF-α in HABECs in response to exosomes, which were isolated from peripheral blood serum of MPP patients. We found that, compared to normal, MPP patients exhibited a significant up-regulated miR-222-3p. Further, exosomal miR-222-3p downregulated SOD2 activity but promoted nuclear NF-κB activity and expression of IL-6 and TNF-α in HABECs, ultimately leading to an oxidative stress condition. Interestingly, such stimulating effects were attenuated by the pretreatment of KuA. This study suggests a critical role possessed by KuA in MPP by regulating the miR-222-3p/SOD2 axis, which represents a promising strategy for the treatment of MPP.
Classification of Buchsbaum subvarieties of codimension 2 in projective space.

For n = 3 the rational quartic is the only "nongeneral-type" Buchsbaum curve. So in this paper we do the cases n = 4 and n = 5. If Υ is of general type, then we follow the tradition and consider it s classified. From (*) we compute the intersection numbers HK of Υ by the Chern classes of */y. One simple observation is that with HK9 pa(Y) and pe(7nH) given s those of the nongeneral-type nonsingular Buchsbaum varieties, the Buchsbaum property is open in the family (see Corollary 1. 5). The surfaces under consideration have very small degree and sectional genus and have been studied by various authors, e.g. Lanteri [La], Livorni [Ll]—[L3] and Okonek [ l]—[O3]. Here we give an outline of the simple argument for the readers' convenience. As an easy application, we see (Corollary 2.4) that the moduli spaces of K 3 surfaces of genus 7 and genus 8 are unirational.
Hand Grip Strength as an Index of Health Does Not Associate With Insomnia: A Cross-Sectional Study

Introduction Insomnia is one of the most prevalent diseases globally, with many adults around the world suffering from at least one of its symptoms. It has a significant effect on the body's normal physiology and may lead to the development of chronic diseases that impair the main functional domains of health and cognition if left untreated. Handgrip strength (HGS) has previously been linked to several diseases that occur in tandem with insomnia. Thus, this study aimed to investigate the association between HGS and insomnia. Materials and methods This is a cross-sectional study in which the involved participants were approached in different locations. The participants were surveyed using the Insomnia Severity Index (ISI) to evaluate the presence of insomnia. A hydraulic hand dynamometer was used to measure the HGS of the participants' right and left hands. Results A total of 494 questionnaires were collected, including 365 (74%) males and 129 females (26%). About 16% of females had insomnia, compared to 15% of males. There was no significant association between gender and insomnia (P=0.873). The difference between the mean HGS for the right and left hands among males and females was not statistically significant (P>0.05). The correlation coefficients of the right and left HGS scores with insomnia were r=0.019 and r=0.018, respectively, which showed no statistically significant association (P>0.05). Conclusions The study found no significant association between HGS and insomnia. The study recommends conducting further large-scale studies focusing on specific groups in the population to understand the relationship between HGS and chronic sleep disturbance.
Behind the Skyscrapers: An Assessment of Dubai’s Cultural and Creative Scene

Dubai has witnessed an upsurge of creative and cultural initiatives within the years of 2020 and 2021 with strong plans and strategies of becoming the hub of creative economy in the coming years. This research traces the arts, culture, and creativity within the city to produce a comprehensive timeline and an assessment of the repository of its physical manifestations in the city. Focusing on three main districts: Dubai Historical District, Al Serkal Avenue, and Dubai Design District, the narrative of arts and gentrification are explored in relationship to governance, urban development, and social life. The findings reflect on the path of culture and creativity in Dubai’s urban fabric and explores the resilience of its network in relation to factors such as community engagement, financial risks, tourist activity, and global changes to assess best practices and envisage a plan of action for the new strategies put forth.
retrospective assessment of the early and medium outcomes of on-pump beating-heart versus off-pump CABG in patients with moderate left ventricular dysfunction (LVEF)

Aim: To compare the early and medium outcomes of on-pump beating-heart (OPBH) coronary artery bypass grafting (CABG) and off-pump CABG (OPCABG) in patients with left ventricular ejection fraction (LVEF) between 30% and 40%. Material & Methods: This study was conducted as a retrospective observation over a period of 1 year at the Department of Cardiothoracic and Vascular Surgery, Indira Gandhi Institute of medical Sciences, Patna, Bihar, India.130 patients were selected for this study. All patients were divided into 2 groups, according to the revascularization method: OPCABG group and OPBH group. Results: LVEF before discharge significantly improved from 34.39 ± 4.21 to 44.27 ± 7.29 in the OPBH group and from 34.27±4.61 to 42.66 ± 8.20in the OPCABG group (P<0.001). All survival patients have been echocardiographically examined after 6 months which showed a significant higher early postoperative LVEF in the OPBH group than in the OPCABG group (45.28 ± 6.10 versus 44.42 ± 7.08%, respectively; P=0.002). Conclusion: The OPBH technique was a safe and an acceptable alternative for surgical revascularization in patients with moderate left ventricular dysfunction which provided better midterm MACE-free survival compared with OPCABG.
Nonlinear Positioning Control for Underactuated Unmanned Surface Vehicles in the Presence of Environmental Disturbances

This article presents a nonlinear positioning control method for underactuated marine surface vehicles via the adaptive heading assignment to resist unknown environmental disturbances. A coordinate system rotated about the desired position is established and three control objectives are presented, namely, the along-track error minimization, the yaw-track error minimization, and the rotated adaption of this coordinate system. The last control objective is to minimize the cross-track error by properly making use of the sway disturbance force. The cross-track stability analysis shows that the proposed adaptive law to adjust the rotated coordinate system can make the cross-track system globally bounded and locally exponentially stable when the control gain of the proposed adaptive law is appropriately set. Both simulated and experimental validations demonstrate that the vehicle can keep the preset desired position when the sway disturbance force added to the vehicle hull is close to zero and the vehicle orientation toward the opposite mean disturbance force is maintained at the same time.