Miracle-dz/UniFAR-FTUs huggingface dataset:
Review and Prospect of GNSS Receiver Autonomous Integrity Monitoring

The rapid development of the global satellite navigation systems poses a new challenge to the safety of civil aviation,and integrity monitoring becomes a more prominent problem.Receiver autonomous integrity motoring(RAIM) is one focus of research,for which the system must provide the required navigation performance for civil aviation specified in terms of the four parameters of accuracy,integrity,availability and continuity.Recent developments in related fields are reviewed,including RAIM with single and multiple satellite failures,and under Gaussian noise environment.The review especially involves the monitoring algorithm,the protection limit and availability,and then points out shortcomings of present research.In addition,new trends and recent research results are introduced.Finally,future research directions are examined.
Network pharmacology and molecular docking analysis reveals the mechanism of asiaticoside on COVID-19

Background Asiaticoside (AS) is a saponin extracted from the traditional Chinese herbal medicine Centella Asiatica, which has the effects of reducing inflammatory infiltration and anti-oxidation in pneumonia and combating pulmonary fibrosis. We hypothesize that AS might have therapeutic potential for the treatment of the coronavirus disease 2019 (COVID-19). With the help of network pharmacology and molecular docking techniques, this study discussed the underlying molecular mechanism of AS in the treatment of COVID-19. Methods The molecular structure of AS was obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) system. The targets of AS were achieved using PharmMapper, SwissTargetPrediction, and the Comparative Toxicogenomics Database (CTD). The targets corresponding to COVID-19 were obtained using GeneCards, Online Mendelian Inheritance in Man (OMIM), and CTD database. Then, a target protein-protein interaction (PPI) network was formed using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database. A network of AS, COVID-19, and their co-targets was built using Cytoscape. Afterwards, the co-targets were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. Moreover, the predictions of crucial targets were further investigated by performing molecular docking with AS. Results A total of 45 core targets of AS were found to be engaged in the pathogenesis of COVID-19. The KEGG enrichment analysis indicated that AS might be protective against COVID-19 through inflammation- and immune-related signaling pathways, including interleukin-17 (IL-17) signaling, T helper 17 (Th17) cell differentiation pathway, Coronavirus disease-COVID-19, MAPK, the PI3K-Akt signaling pathway, and so on. The results of molecular docking showed that AS had a high affinity with those core targets. Conclusions The beneficial effect of AS on COVID-19 might be through regulating multiple immune or inflammation-related targets and signaling pathways.
The HIFα-Stabilizing Drug Roxadustat Increases the Number of Renal Epo-Producing Sca-1+ Cells

Inhibition of the prolyl-4-hydroxylase domain (PHD) enzymes, leading to the stabilization of hypoxia-inducible factor (HIF) α as well as to the stimulation of erythropoietin (Epo) synthesis, is the functional mechanism of the new anti-anemia drug roxadustat. Little is known about the effects of roxadustat on the Epo-producing cell pool. To gain further insights into the function of PHD inhibitors, we characterized the abundance of mesenchymal stem cell (MSC)-like cells after roxadustat treatment of mice. The number of Sca-1+ mesenchymal cells following roxadustat treatment increased exclusively in the kidneys. Isolated Sca-1+ cells demonstrated typical features of MSC-like cells, including adherence to tissue culture plates, trilineage differentiation potential, and expression of MSC markers. Kidney-derived Sca-1+ MSC-like cells were cultured for up to 21 days. Within the first few days in culture, cells stabilized HIF-1α and HIF-2α and temporarily increased Epo production upon incubation in hypoxia. In summary, we have identified a Sca-1+ MSC-like cell population that is involved in renal Epo production and might contribute to the strong anti-anemic effect of the PHD inhibitor roxadustat.
Improving Visual-Patient-Avatar Design Prior to Its Clinical Release: A Mixed Qualitative and Quantitative Study

Visual-Patient-avatar, an avatar-based visualisation of patient monitoring, is a newly developed technology aiming to promote situation awareness through user-centred design. Before the technology’s introduction into clinical practice, the initial design used to validate the concept had to undergo thorough examination and adjustments where necessary. This mixed qualitative and quantitative study, consisting of three different study parts, aimed to create a design with high user acceptance regarding perceived professionalism and potential for identification while maintaining its original functionality. The first qualitative part was based on structured interviews and explored anaesthesia personnel’s first impressions regarding the original design. Recurrent topics were identified using inductive coding, participants’ interpretations of the vital sign visualisations analysed and design modifications derived. The second study part consisted of a redesign process, in which the visualisations were adapted according to the results of the first part. In a third, quantitative study part, participants rated Likert scales about Visual-Patient-avatar’s appearance and interpreted displayed vital signs in a computer-based survey. The first, qualitative study part included 51 structured interviews. Twenty-eight of 51 (55%) participants mentioned the appearance of Visual-Patient-avatar. In 23 of 51 (45%) interviews, 26 statements about the general impression were identified with a balanced count of positive (14 of 26) and negative (12 of 26) comments. The analysis of vital sign visualisations showed deficits in several vital sign visualisations, especially central venous pressure. These findings were incorporated into part two, the redesign of Visual-Patient-avatar. In the subsequent quantitative analysis of study for part three, 20 of 30 (67%) new participants agreed that the avatar looks professional enough for medical use. Finally, the participants identified 73% (435 of 600 cases) of all vital sign visualisations intuitively correctly without prior instruction. This study succeeded in improving the original design with good user acceptance and a reasonable degree of intuitiveness of the new, revised design. Furthermore, the study identified aspects relevant for the release of Visual-Patient-avatar, such as the requirement for providing at least some training, despite the design’s intuitiveness. The results of this study will guide further research and improvement of the technology. The study provides a link between Visual-Patient-avatar as a scientific concept and as an actual product from a cognitive engineering point of view, and may serve as an example of methods to study the designs of technologies in similar contexts.
Enhancing the in vivo stability of polycation gene carriers by using PEGylated hyaluronic acid as a shielding system

To increase the in vivo stability of cationic gene carriers and avoid the adverse effects of their positive charge, we synthesized a new shielding material by conjugating low molecular weight polyethylene glycol (PEG) to a hyaluronic acid (HA) core. The HA-PEG conjugate assembled with the positively charged complex, forming a protective layer through electrostatic interactions. DNA/polyetherimide/HA-PEG (DNA/PEI/HA-PEG) nanoparticles had higher stability than both DNA/polyethyleneimine (DNA/PEI) and DNA/PEI/HA complexes. Furthermore, DNA/PEI/HA-PEG nanoparticles also showed a diminished nonspecific response toward serum proteins in vivo. The in vivo transfection efficiency was also enhanced by the low cytotoxicity and the improved stability; therefore, this material might be promising for use in gene delivery applications.
Stress, Inflammation and Metabolic Biomarkers Are Associated with Body Composition Measures in Lean, Overweight, and Obese Children and Adolescents

The aim of this study was to examine the associations between multiple indices of stress, inflammation and metabolism vs. body composition parameters in 121 (43 boys, 78 girls) children and adolescents, aged 5–15 y. Subjects were divided into two groups: normal weight (N) (N = 40, BMI z-score = −0.1923 ± 0.6), and overweight/obese (OB) (N = 81, BMI z-score = 2.1947 ± 1.4). All subjects completed the State-Trait Anxiety Inventory for Children (STAIC) and Children’s Depression Inventory, and underwent cortisol measurements in hair, diurnal series of saliva, and morning serum. Circulating concentrations of high sensitivity C-reactive protein (hsCRP) and other inflammation biomarkers were also obtained. Body composition analysis was performed with a clinically validated, advanced bioimpedance apparatus (BIA), while heart rate variability (HRV) was measured as a stress biomarker by photoplethysmography (PPG). The OB group had a higher STAIC-state score, waist-to-hip ratio, skeletal muscle mass, and total and abdominal fat mass, and a lower percent fat-free mass (FFM) and bone density than the N group. HRV did not differ between the groups. In the entire population, percent fat mass correlated strongly with circulating hsCRP (r = 0.397, p = 0.001), ferritin, and other inflammatory biomarkers, as well as with indices of insulin resistance. A strong correlation between serum hsCRP and hair cortisol was also observed (r = 0.777, p < 0.001), suggesting interrelation of chronic stress and inflammation. Thus, body fat accumulation in children and adolescents was associated with an elevation in clinical and laboratory biomarkers of stress, inflammation, and insulin resistance. BIA-ACC and PPG can be utilized as a direct screening tool for assessing overweight- and obesity -related health risks in children and adolescents.
Association between sleep insufficiency and dyslipidemia: a cross-sectional study among Greek adults in the primary care setting

Objective To investigate the potential association between sleep insufficiency and dyslipidemia (DL) in the primary care setting using self-reported questionnaires. Material and Methods 957 adults aged between 19 and 86 years old from the rural area of Thrace, Greece were enrolled in this cross-sectional study. Multistage stratifed cluster sampling was used and the subjects were classifed into three groups according to sleep duration [short (<6h), normal (6-8h), and long (>8h) sleep duration]. DL was defined by a positive response to the question “Have you ever been told by a doctor or health professional that your blood cholesterol or triglyceride levels were high? ”, or if they were currently taking antilipidemic agents. Sleep quality, utilizing Epworth sleepiness scale, Athens insomnia scale, Pittsburgh sleep quality index and Berlin questionnaire, was also examined. Results DL prevalence was significantly associated with short sleep duration (aOR=2.18, p<0.001) and insomnia (aOR=1.43, p=0.050), while its relation with poor sleep quality (aOR=1.31, p=0.094) and risk for obstructive sleep apnea (aOR=1.32, p=0.097) were of marginal statistical significance. Concerning insomnia subtypes, DL was significantly associated with difficulties maintaining sleep (aOR=2.99, p<0.001) and early morning awakenings (aOR=1.38, p=0.050), but not difficulties initiating sleep (aOR=1.18, p=0.328). Conclusion This study reveals an association between sleep pathology and DL. Thus, early pharmacological and cognitive or behavioral interventions that improve sleep are deemed necessary in order to decrease DL burden.
Understanding the PEDOT:PSS, PTAA and P3CT-X Hole-Transport-Layer-Based Inverted Perovskite Solar Cells

The power conversion efficiencies (PCEs) of metal-oxide-based regular perovskite solar cells have been higher than 25% for more than 2 years. Up to now, the PCEs of polymer-based inverted perovskite solar cells are widely lower than 23%. PEDOT:PSS thin films, modified PTAA thin films and P3CT thin films are widely used as the hole transport layer or hole modification layer of the highlyefficient inverted perovskite solar cells. Compared with regular perovskite solar cells, polymer-based inverted perovskite solar cells can be fabricated under relatively low temperatures. However, the intrinsic characteristics of carrier transportation in the two types of solar cells are different, which limits the photovoltaic performance of inverted perovskite solar cells. Thanks to the low activation energies for the formation of high-quality perovskite crystalline thin films, it is possible to manipulate the optoelectronic properties by controlling the crystal orientation with the different polymer-modified ITO/glass substrates. To achieve the higher PCE, the effects of polymer-modified ITO/glass substrates on the optoelectronic properties and the formation of perovskite crystalline thin films have to be completely understood simultaneously.
Numerical study on adjustment of the main flow field with guide vanes in transition zone for an S-duct

A 30°/30° S-duct is often employed by a modern civil and military aircraft. Due to the vortex generators have poor control effect on the flow separation in the large curvature S-duct, so a new method adjusting the direction of the main flow in the transition zone for S-duct is proposed in the present study. These studies are carried out by solving Navier-Stokes equations with SST k-ω turbulence model. In order to explore the control mechanism of guide vanes on the flow field for S-duct, the internal flow field of S-duct with/without guide vanes is analyzed and compared in detail, including the velocity distribution on the symmetry plane, the secondary vortex intensity at different cross sections, turbulent kinetic energy on different cross sections, total pressure distribution on different cross sections, three-dimensional streamline, and so on. The results show that guide vanes can not only effectively adjust the direction of the main flow, but also restrain the flow separation, reduce the total pressure loss, and improve the uniformity of flow field.
Tapped Inductor Quasi-Z-source Inverters

This paper proposed a high inversion gain single stage Boost inverter,which introduces a tapped inductor impedance network into the traditional quasi-Z-source inverters(qZSI),called tapped inductor quasi-Z-source inverters(TL-qZSI). The tapped inductor network includes one tapped inductor and two diodes and is used to replace one inductor of the traditional qZSI.Similar to the tapped inductor Z-source inverter(TL-ZSI),the proposed inverter also can provide high inversion gain,which is lower than that of TL-ZSI.This paper analyzed the circuit operation principle,boost inversion features and its control strategy.Design consideration was also discussed.Experimental results were provided to verify its effectiveness and demonstrate the real characteristics of the proposed circuit.
Large Deflection Mechanical Characteristics of Graphene Films

Considering the mechanical behavior analysis of graphene film for micro-pressure sensor, the load-deflection models in graphene film are established based on the large deflection elastic theory of circular film. With regard to the typical load-deflection models, the effects of the film parameters, including elastic modulus and film layer, on deflection deformation and vibration behavior are computed numerically and simulated by using nonlinear statics analysis and mode analysis units with ANSYS software. The results show that the prestressing force has a significant impact on the deflection deformation at low load, and especially there is a linear relation between load and deflection in the pressure range from 0 to 3.6 k Pa. However, a decreasing effect on the deflection deformation is produced by the above-mentioned film parameters with the increase of pressure load. Also, the natural frequency and mode shape characteristics mainly depend on the prestressing force instead of these two film parameters. This phenomenon verifies the used validity of spherical shell theoretical model because of the average relative error less than 0.49% between the analytical solution and ANSYS simulation results in the presence of prestressing force in the aforementioned pressure range.
‘They are Alone in Their Parenthood’: Parenting Support and (Re)building Community

This article uniquely contributes to critical discussions about parenting support in contemporary social science research that has examined the recent political and public attention on parenting. The studies highlight the increased attention on individualised parenting support focused on the parent–child relationship. Based on an analysis of 310 family support projects initiated in Finland, this research found that another orientation exists alongside individualised parenting support, which has gained only little attention in recent studies about parenting support. That alternative focuses on a communal parenting support, wherein parenting support is conducted by means of community (re)building. This article summarises how anxiety about parenting overlaps with discussions about community as well as ‘the family decline’, creating a need for community (re)building. In this study, I show how concern within family support projects is harnessed to establish ‘communion’, representing a third category alongside the more common sociological notions of ‘society’ and ‘community’. However, fundamental tensions appear as projects attempt to build community, which I also discuss in this article.
Nutritional Characterization of Strychnos madagascariensis Fruit Flour Produced by Mozambican Communities and Evaluation of Its Contribution to Nutrient Adequacy

The indigenous fruit Strychnos madagascariensis is usually processed to flour, called nfuma, being highly consumed during staple food shortage. This study aimed to evaluate the nutritional composition of nfuma and its nutrient adequacy. Flours from four districts of Mozambique were analyzed using AOAC methods for proximate composition, HPLC for sugar, amino acids (AA), vitamin E and carotenoids and ICP-MS and FAAS for minerals. The results showed that nfuma stands out for its high content of fat (26.3–27.8%), mainly oleic acid, fiber (>6%), vitamin E (6.7 to 8.0 mg/100 g) and carotenes (2.2 to 2.6 mg/100 g). The main amino acids of nfuma protein were Arg, Asp and Glu, and Lys was the limiting one. The mineral composition reveals K (~1200 to 1700 mg/100 g) as the main macromineral followed by Mg > Ca > Na. The main trace element was Mn (~4 mg/100 g) followed by Fe > Zn > Cu > Cr > Co. Aluminum (~3 mg/100 g) was the main non-essential element and Rb, Ni, Sr, Ba, V, Cd were also quantified. Assuming the daily consumption of 50 g, nfuma provides 82% of Vitamin A dietary reference value for toddlers, while the consumption of 100 g contributes to 132% and 60% of Mn and vitamin A DRV for adults, respectively. Despite the nutritional advantages of nfuma, this flour can be a source of Ni, highlighting the importance of the study of good practices in its preparation to decrease the exposure to non-essential elements.
Organizational Culture and Its Association with Job Satisfaction among Hospital Employees

Introduction: Organizations are dynamic places; health care organizations are service organizations with a complex social system of employees. Organizational culture is commonly defined as the shared values, beliefs, and assumptions that guide employees' behavior and work style, thus affecting performance and job satisfaction. This study examines organisational culture and determines the association between organizational culture and job satisfaction. Methodology: It was a descriptive cross-sectional survey study where the study population was categorized into clinical and non-clinical categories. A total of 196 employees from 18 to 60years of age were included using stratified random sampling. Organizational Culture is measured using factors: Innovation and risk-taking, Openness, Identity, Result Orientation and Management Support. Job satisfaction is measured using variables: Job nature, Job security, Talent used in the job, working hours, relationship with co-workers and supervisors, and Job recognition. Participants’ responses were recorded on the Likert scale. ANOVA, T-test, and chi-square test were used to analyze the data Results: The study finds that "Identity" and Openness" are dominant cultural factors. 90.5% of the employees who said Organisation culture is good rated their satisfaction level as good.100% of the clinical staff said they take pride in working for the organisation and study and culture and Job satisfaction association P-value is <0.001. Conclusion: The study setting finds a strong association between Organizational Culture and job satisfaction and finds majority of the employees are highly satisfied Key words: Organization Culture, Job Satisfaction, and Job Satisfaction Association.
ABSTRACT PLANNING SYSTEMS IN AUTONOMOUS ROBOTS PLANIFICACIÓN ABSTRACTA EN LOS SISTEMAS DE ROBOTS AUTÓNOMOS

This paper proposes a model of motion planning for a mobile robot that integrates within a hierarchy of abstraction of the problem a planning technique based on cases and path planning technique that uses approximate decomposition cells. The implementation of the model is evaluated within a Lego NXT robot and the results of this evaluation showed improvement over the movement planner appCells.
ZnO Electrodeposition Model for Morphology Control

In this research, a model for electrodeposition of zinc oxide (ZnO) nanostructures over indium-doped tin-oxide (ITO) glass using pulsed current and zinc chloride as source of zinc was proposed. For the model, reactions kinetics rate constants were evaluated by obtaining the reaction product solid mass of the various species through time using an electrochemical quartz crystal microbalance (EQCM). To obtain a mathematical model of the electrodeposition using Ansys CFX 2D simulation software, the reaction kinetics rates were used to calculate mass transfer in the volume closest to the surface. The model was applied to the experimental electrodeposition conditions to validate its accuracy. Dense wurtzite nanostructures with controlled morphology were obtained on a indium-doped tin-oxide (ITO) glass. Sample characterization was performed using high-resolution field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM) on focused ion beam milled (FIBed) sheets from wurtzite mono-crystals. Average crystallite size was evaluated by X-ray diffraction (XRD) using the Scherrer equation, and superficial areas were evaluated by Brunauer, Emmett, and Teller (BET) method. Through the experimental results, a chemical model was developed for the competing reactions based on the speciation of zinc considering pH evolution, and kinetic constants, on the oxygen rich aqueous environment. Owing to the model, an accurate prediction of thickness and type of electrodeposited layers, under given conditions, is achieved. This allows an excellent control of the optical properties of Wurtzite as a photon absorber, for an efficient separation of the electron-hole pair for conduction of the electric charges formed. The large surface area, and small wurtzite crystallites evenly distributed on the thin film electrodeposited over the ITO conductive layer are promising features for later dye-sensitized photovoltaic cell production.