Miracle-dz/UniFAR-FTUs huggingface dataset:
An inclusion-consistent solution to the problem of absurd confidence statements: 2. Consistent nonexact-confidence-interval estimation

An example is given of a uniformly most accurate unbiased confidence belt which yields absurd confidence statements with 100% occurrence. In several known examples, as well as in the 100%-occurrence counterexample, an optimal confidence belt provides absurd statements because it is inclusion-inconsistent with either a null or an all-inclusive belt or both. It is concluded that confidence-theory optimality criteria alone are inadequate for practice, and that a consistency criterion is required. An approach based upon inclusion consistency of belts [C(x) C C C(x), for some x, implies γ ≤ γ for confidence coefficients] is suggested for exact interval estimation in continuous parametric models. Belt inclusion consistency, the existence of a proper-pivotal vector [a pivotal vector T(X, θ) such that the effective range of T(x,.) is independent of x], and the existence of a confidence distribution are proven mutually equivalent. This consistent approach being restrictive, it is shown, using Neyman's anomalous 1954 example, how to determine whether any given parametric function can be estimated consistently and exactly or whether a consistent nonexact solution must be attempted. On cite un exemple d'une ceinture de confiance uniformement la plus precise sans biais, donnant lieu a des enonces de confiance absurdes dans une proportion de 100%. Dans maints exemples connus, comme dans le contre-exemple du 100%, une ceinture de confiance optimale donne lieu a des enonces absurdes parce qu'elle est inconsistante sous l'inclusion dans ses rapports avec la ceinture vide, avec la ceinture universelle, ou avec les deux. On conclut que les criteres d'optimalite de la theorie des ensembles de confiance sont, a eux seuls, inadequats pour la pratique et qu'un critere de consistance est requis. Une methode basee sur la consistance sous l'inclusion de ceintures [C(x) C C(x), pour au moins un x, implique que les coefficients de confiance satisfont γ ≤ γ≤] est suggeree pour l'estimation exacte par un intervalle dans un modele parametrique continu. On prouve que la consistance de ceintures sous l'inclusion, l'existence d'un vecteur proprement pivotal [un vecteur pivotal T(X, θ) tel que la codomaine effectif de T(x,.) soil independant de x] et l'existence d'une distribution de confiance sont mutuellement equivalentes. La methode de la consistant etant restrictive, on montre, a l'aide de l'exemple d'anomalie cite par Neyman en 1954, comment determiner si une fonction parametrique donnee peut etre estimee de facon consistante et exacte, ou si on doit plutot chercher une solution consistante non exacte.
Temporal trends in, and associations of, early-career general practitioner prescriptions of second-line Type 2 Diabetes medications, 2010–2018

Introduction Second-line pharmacotherapy for Type 2 Diabetes Mellitus (‘diabetes’) is necessary for optimal glycaemic control and preventing longer-term complications. We aimed to describe temporal trends in, and associations of, Australian general practitioner (GP) registrars’ prescription, and initiation, of ‘new’ second-line oral agents (dipeptidyl peptidase 4 inhibitors, sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide 1 agonists) compared to sulphonylureas. Materials and methods A longitudinal analysis (2010–2018) of data from the Registrar Clinical Encounters in Training project. Analysis included any diabetes problem/diagnosis that involved prescription of sulphonylureas or ‘new’ oral agents. Simple and multiple logistic regression models were fitted within the generalised estimating equations framework. Results 2333 registrars recorded 6064 diabetes problems/diagnoses (1.4%). 835 problems/diagnoses involved sulphonylurea or ‘new’ medication prescription. Of these, 61.0% [95% CI:57.4–64.4] involved ‘new’ medication prescription. 230 problems/diagnoses involved sulphonylurea or ‘new’ medication initiation, with 77% [95%CI:70.8–82.1] involving a ‘new’ medication. There was a significant 52% per year increase in prescribing (OR = 1.52[95% CI:1.38–1.68],p<0.001), and a 77% per (two-to-three-year) time-interval increase in initiation (OR = 1.77,[95% CI:1.30–2.43],p = <0.001) of ‘new’ medications compared to sulphonylureas. ‘New’ medications were prescribed less for non-English-speaking patients. There was some regional variation in prescribing. Conclusion Registrar uptake of ‘new’ oral agents compared to sulphonylureas has increased rapidly.
Pathobiology, Severity, and Risk Stratification of Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference

OBJECTIVES: To review the literature for studies published in children on the pathobiology, severity, and risk stratification of pediatric acute respiratory distress syndrome (PARDS) with the intent of guiding current medical practice and identifying important areas for future research related to severity and risk stratification. DATA SOURCES: Electronic searches of PubMed and Embase were conducted from 2013 to March 2022 by using a combination of medical subject heading terms and text words to capture the pathobiology, severity, and comorbidities of PARDS. STUDY SELECTION: We included studies of critically ill patients with PARDS that related to the severity and risk stratification of PARDS using characteristics other than the oxygenation defect. Studies using animal models, adult only, and studies with 10 or fewer children were excluded from our review. DATA EXTRACTION: Title/abstract review, full-text review, and data extraction using a standardized data collection form. DATA SYNTHESIS: The Grading of Recommendations Assessment, Development, and Evaluation approach was used to identify and summarize relevant evidence and develop recommendations for clinical practice. There were 192 studies identified for full-text extraction to address the relevant Patient/Intervention/Comparator/Outcome questions. One clinical recommendation was generated related to the use of dead space fraction for risk stratification. In addition, six research statements were generated about the impact of age on acute respiratory distress syndrome pathobiology and outcomes, addressing PARDS heterogeneity using biomarkers to identify subphenotypes and endotypes, and use of standardized ventilator, physiologic, and nonpulmonary organ failure measurements for future research. CONCLUSIONS: Based on an extensive literature review, we propose clinical management and research recommendations related to characterization and risk stratification of PARDS severity.
Signaling pathways underlying nitrogen transport and metabolism in plants

Nitrogen (N) is an essential macronutrient required for plant growth and crop production. However, N in soil is usually insufficient for plant growth. Thus, chemical N fertilizer has been extensively used to increase crop production. Due to negative effects of N rich fertilizer on the environment, improving N usage has been a major issue in the field of plant science to achieve sustainable production of crops. For that reason, many efforts have been made to elucidate how plants regulate N uptake and utilization according to their surrounding habitat over the last 30 years. Here, we provide recent advances focusing on regulation of N uptake, allocation of N by N transporting system, and signaling pathway controlling N responses in plants.
A DUAL RECIPROCITY BOUNDARY ELEMENT APPROACH TO THREE-DIMENSIONAL TRANSIENT HEAT CONDUCTION AS APPLIED TO MATERIALS PROCESSING

The dual reciprocity boundary element method (DRBEM) is implemented to solve three-dimensional transient heat conduction problems in the presence of arbitrary sources, typically as these problems arise in materials processing. The DRBEM has a major advantage over conventional BEM, since it avoids the computation of volume integrals. These integrals stem from transient, nonlinear, and/or source terms. Thus there is no need to discretize the inner domain, since only a number of internal points are needed for the computation. The validity of the method is assessed upon comparison with results from benchmark problems where analytical solutions exist. There is generally good agreement. Comparison against finite element results is also favorable. Calculations are carried out in order to assess the influence of the number and location of internal nodes. The influence of the ratio of the numbers of internal to boundary nodes is also examined.
Prevalence of anxiety disorders and association to socioeconomic position. Results from the Lolland Falster Health Study

Abstract Purpose The purpose of this study is to describe the prevalence of anxiety disorders in a general population and the association to socioeconomic position (SEP), which has not been described in a Danish context before. Material and methods We present data on anxiety symptoms from respondents in the rural-provincial Lolland-Falster population Health Study (LOFUS). Analyses of the questionnaire responses to the Anxiety Symptom Scale were done by descriptive statistics and logistic regression analyses adjusted for sex and age. Results 14,834 LOFUS respondents who completed the Anxiety Symptom Scale were included; According to the original algorithm 371 (2.5%) had an anxiety disorder. The adjusted odds ratios (aOR) for anxiety disorder were strongly associated to SEP. We found aOR for anxiety to be: 3.8 (confidence interval (CI 95%) 2.54 − 5.92) for respondents with no postsecondary education compared to those with 3+ years of postsecondary education; 11.9 (CI 8.89 − 16.01) for respondents temporarily out of a job compared to those working; 9.4 (CI 6.06 − 14.51) for those experiencing constant financial strain compared to those not experiencing financial strain. Relaxing the criteria for anxiety to item 10 > 1, the prevalence raised to 3.9%. The association was unchanged related to education; however, the aOR dropped to 9 and 8 respectively, for being temporally out of job, or in financial strain every month– when doing same comparisons. Conclusions The 14-day prevalence of anxiety disorder seems low but strongly associated to SEP especially for individuals temporarily out of a job or experiencing financial strain.
Evidence of Seasonal Variation in Body Color in Adults of the Parasitoid Cirrospilus pictus (Hymenoptera: Eulophidae) in Sicily, Italy

Simple Summary Many studies highlighted that the body color variation in insects is an adaptation factor that preserves them from possible population reductions due to adverse conditions such as low temperatures. In this study, the coloration seasonal changes of Cirrospilus pictus, parasitoid of the citrus leafminer Phyllocnistis citrella were observed. Adults were obtained from field sampling carried out during four consecutive years and grouped in different classes depending on sex and color. Results highlighted a phenotypic pigmentation variation in head, thorax, gaster and legs of the adults. Individuals were yellow–green in summer months while having dark pigmentation in autumn and winter months. In both sexes a correlation between color patterns and seasonal temperatures was evident. These observations can contribute to the description of the intraspecific variability of this species, improving its identification. Abstract As part of the studies on the morphological color variation of insects, a case study on the seasonal body color variation of Cirrospilus pictus (Nees) (Hymenoptera: Eulophidae: Eulophinae) parasitoid of leafminers is reported. Observations were made from January 2000 to December 2003 in north-western Sicily (Italy), in relation to sex, body regions of adults and seasonal periods. Wasps parasitizing Phyllocnistis citrella Stainton (Lepidoptera: Gracillariidae) were collected from organic citrus orchards (Citrus limon L., var. “Femminello zagara bianca” and “Femminello comune”). Adults were grouped in classes: yellow males, black males, yellow females, yellow–black females and black females. The results highlighted a phenotypic pigmentation variation in the head, thorax, gaster and legs of individuals influenced by the season of sampling. Adults were yellow–green in summer months, whereas individuals with dark pigmentation were found in autumn and winter months. A correlation between color patterns and seasonal temperatures was found for both females and males. This work provides a contribution to the description of the intraspecific variability of this species, improving its identification.
Evidence of Mie scattering at terahertz frequencies in powder materials

We present experimental results as well as modelling concerning terahertz (THz) wave scattering by powder materials with grain size of the order of the wavelength. The studied material is a mixture of high density polyethylene and fructose powders, whose grain size is varied from a sample to another one while the volume concentration is kept constant. Experimental data are recorded with a THz time-domain spectroscopy set up. The scattering contribution to the total propagation loss in such powders shows a resonant behaviour for grain size roughly equal to the THz wavelength, for which it reaches 80%–90% of the total loss. Modelling using Mie theory allows us to well describe the absorption and scattering phenomena.
RNA‐binding proteins in autoimmunity: From genetics to molecular biology

Autoimmune diseases (ADs) are chronic pathologies generated by the loss of immune tolerance to the body's own cells and tissues. There is growing recognition that RNA‐binding proteins (RBPs) critically govern immunity in healthy and pathological conditions by modulating gene expression post‐transcriptionally at all levels: nuclear mRNA splicing and modification, export to the cytoplasm, as well as cytoplasmic mRNA transport, storage, editing, stability, and translation. Despite enormous efforts to identify new therapies for ADs, definitive solutions are not yet available in many instances. Recognizing that many ADs have a strong genetic component, we have explored connections between the molecular biology and the genetics of RBPs in ADs. Here, we review the genetics and molecular biology of RBPs in four major ADs, multiple sclerosis (MS), type 1 diabetes mellitus (T1D), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA). We anticipate that gaining insights into the genetics and biology of ADs can facilitate the discovery of new therapies.
Interpretable Machine Learning of Two‐Photon Absorption

Molecules with strong two‐photon absorption (TPA) are important in many advanced applications such as upconverted laser and photodynamic therapy, but their design is hampered by the high cost of experimental screening and accurate quantum chemical (QC) calculations. Here a systematic study is performed by collecting an experimental TPA database with ≈900 molecules, analyzing with interpretable machine learning (ML) the key molecular features explaining TPA magnitudes, and building a fast ML model for predictions. The ML model has prediction errors of similar magnitude compared to experimental and affordable QC methods errors and has the potential for high‐throughput screening as additionally validated with the new experimental measurements. ML feature analysis is generally consistent with common beliefs which is quantified and rectified. The most important feature is conjugation length followed by features reflecting the effects of donor and acceptor substitution and coplanarity.
Microscopic analysis of generation-recombination noise in semiconductors under dc and time-varying electric fields

We present a microscopic analysis of current fluctuations in a semiconductor sample in the presence of trapping–detrapping processes and conventional scattering mechanisms. An ensemble Monte Carlo simulation is used for calculations. To ensure the linearity of the system, we use a model where the characteristic times of the different microscopic mechanisms are considered as energy independent. We analyze the behavior of thermal and generation-recombination noise spectra under static (dc field) and time-varying (ac field) conditions. Under dc bias we confirm the validity of the microscopic model by comparing the results of the simulation with analytical predictions. When an ac field is applied, amplitude modulation of the semiconductor response takes place due to generation-recombination processes. This modulation leads to the upconversion of the low-frequency generation-recombination spectrum, which is evidenced (even in the absence of dc current) and analyzed under different physical conditions.
Analysis of a Dryline during IHOP: Implications for Convection Initiation

Abstract A detailed analysis of a dryline that formed on 22 May 2002 during the International H2O Project (IHOP) is presented. The dryline was classified as a null case since air parcels lifted over the convergence boundary were unable to reach the level of free convection preventing thunderstorms from forming. A secondary dryline associated with a distinct moisture discontinuity developed to the west of the primary dryline. The primary dryline exhibited substantial along-frontal variability owing to the presence of misocyclones. This nonlinear pattern resembled the precipitation core/gap structure associated with cold fronts during one of the analysis times although the misocyclones were positioned within the gap regions. Radar refractivity has been recently shown to accurately retrieve the low-level moisture fields within the convective boundary layer; however, its use in forecasting the initiation of convection has been restricted to qualitative interpretations. This study introduces the total derivati.
A Case Manager-Led Pneumonia Care Bundle in a Subacute Rehabilitation Facility

Purpose of the Study: To evaluate the relationship between a case manager-led pneumonia care bundle at skilled nursing facilities (SNFs) and 30-day hospital readmissions for pneumonia. Primary Practice Settings: The primary practice settings included patients hospitalized with pneumonia at 2 community hospitals between October 2018 and June 2019 and who were subsequently transferred to an SNF. Methodology and Sample: A retrospective cohort study was completed comparing patients in the preintervention cohort who received pneumonia standard of care versus patients in the postintervention cohort who received a case manager-led evidence-based pneumonia care bundle at an SNF. From October 2018 to June 2019, patients admitted with pneumonia to 2 community hospitals in Northwest New Jersey were enrolled in the preintervention cohort. Patients admitted with pneumonia from January 2020 to June 2021 were enrolled in the postintervention group. The primary outcome was to reduce 30-day readmission rates for all patients discharged from the hospital to an SNF with pneumonia. Results: Ninety-nine patients were enrolled in the preintervention cohort and 34 patients were enrolled in the postinterventions cohort. Thirty-day readmission rates were lower in the postintervention cohort (24.2% vs. 17.7%). This reduction in readmission rates was clinically significant, demonstrating a 27% reduction for all patients discharged from the hospital to an SNF with pneumonia. Implications for Case Management Practice: Individualized pneumonia self-management education can be easily implemented in SNFs to improve quality-of-care outcomes for patients. Our health care system collaborates with several SNFs to decrease 30-day hospital readmission. The pneumonia care bundle includes specific measures to improve the transition of care for patients with pneumonia by decreasing the variability of patient care after discharge from the hospital to an SNF. It was hypothesized that to decrease readmissions from the SNFs, we needed to address the quality of care provided by the SNFs by using a 2-prong approach; education of SNF staff on the pneumonia care bundle, and in-person weekly follow-up visits in the SNF until discharge from the SNF to the patient's home.
Identifying socioeconomic and biophysical factors driving forest loss in protected areas

Protected areas (PAs) are a commonly used strategy to confront forest conversion and biodiversity loss. Although determining drivers of forest loss is central to conservation success, understanding of them is limited by conventional modeling assumptions. We used random forest regression to evaluate potential drivers of deforestation in PAs in Mexico, while accounting for nonlinear relationships and higher order interactions underlying deforestation processes. Socioeconomic drivers (e.g., road density, human population density) and underlying biophysical conditions (e.g., precipitation, distance to water, elevation, slope) were stronger predictors of forest loss than PA characteristics, such as age, type, and management effectiveness. Within PA characteristics, variables reflecting collaborative and equitable management and PA size were the strongest predictors of forest loss, albeit with less explanatory power than socioeconomic and biophysical variables. In contrast to previously used methods, which typically have been based on the assumption of linear relationships, we found that the associations between most predictors and forest loss are nonlinear. Our results can inform decisions on the allocation of PA resources by strengthening management in PAs with the highest risk of deforestation and help preemptively protect key biodiversity areas that may be vulnerable to deforestation in the future.
Constructive and destructive interaction modes between two tandem flexible flags in viscous flow

Two tandem flexible flags in viscous flow were modelled by numerical simulation using an improved version of the immersed boundary method. The flexible flapping flag and the vortices produced by an upstream flag were found to interact via either a constructive or destructive mode. These interaction modes gave rise to significant differences in the drag force acting on the downstream flapping flag in viscous flow. The constructive mode increased the drag force, while the destructive mode decreased the drag force. Drag on the downstream flexible body was investigated as a function of the streamwise and spanwise gap distances, and the bending coefficient of the flexible flags at intermediate Reynolds numbers (200 ≤ Re ≤ 400).
PV-θ view of the zonal mean state of the atmosphere

ABSTRACT The relation between zonal mean potential vorticity (PV) in potential temperature (θ) coordinates and the zonal mean zonal wind in January and in July is studied. PV-anomalies are defined with respect to a reference state that is at rest with respect to the rotating earth. Two important PV-anomalies are identified. One PV-anomaly, the ‘Ex-UTLS PV-anomaly’, coincides approximately with the extratropical tropopause (310–360 K). It is a permanent feature of the zonal mean state. The other PV-anomaly is located higher in the stratosphere. It exhibits a strong seasonal cycle, i.e. in winter, it is strongly positive, while in summer, it is weakly negative. In the Northern Hemisphere winter, the Ex-UTLS PV-anomaly and the stratospheric PV-anomaly are separated by a ‘surf-zone’, which is characterised by a negative PV-anomaly pole-wards of a positive PV-anomaly. Piecewise PV-inversion reveals that (1) the Ex-UTLS PV-anomaly induces the westerly winds in the troposphere and the lower stratosphere, including the subtropical jet, that (2) the positive stratospheric PV-anomaly induces the stratospheric polar night jet and that (3) the negative polar cap stratospheric PV-anomaly in summer reduces the westerly wind speeds in the troposphere and induces easterly winds in the stratosphere. The Ex-UTLS PV-anomaly is manifest mainly as an isentropic density- (or mass-) anomaly. Piecewise PV-inversion of these anomalies in isolation should account for this by an appropriate adjustment of the lower boundary condition.