Miracle-dz/UniFAR-FTUs huggingface dataset:
Improving coordination skills in young football players aged 8-10 years

The assumptions underlying the current direction of research have been determined by both the decreasing level of the football game in the investigated age group and the failure to exploit the impressive skills that a child aged 8-10 years is able to develop as a result of proper training. In our country, the current game of football for children aged between 8 and 10 years does not focus on the development of their creativity and coordination skills, but predominantly on the systematic tactical game following various predefined play routes. Taking into account the above, we consider it imperative to optimise the coordination skills of young players. The purpose of this research is to improve the level of coordination skills in a team of children aged 8-10 years through means specific to the game of football. During the research, two assessments were performed to determine the level of coordination skills by using the Agility T-Test (BlazePod technology) and Adams Test, which are specific for the assessment of these qualities. The research includes 42 male players aged between 8 and 10 years, as members of two football clubs, namely FC Chelsea Bucharest and FC Tineretul Bucharest. The research methods used are: documentation, experiment, recording, conversation, mathematical statistics and graphical representation. The statistically significant differences allow us to say that the improvements achieved are not random but are also due to the exercise programme intervention. As regards the T-Test specific to coordination skills, an improvement of 0.12 sec is noted for the experimental group and an improvement of only 0.05 sec for the control group.
Evaluation of miR-let-7f, miR-125a, and miR-125b expression levels in sputum and serum samples of Iranians and Afghans with pulmonary tuberculosis

Background and Objectives: The role of microRNAs (miRNAs) in tuberculosis infection is well established. As microRNAs are able to change expression profiles according to different conditions, they can be useful biomarkers. Iranians and Afghans with tuberculosis were studied for three immune-related miRNAs (miR-let-7f, miR-125a, and miR-125b). Materials and Methods: A total of 60 Iranian and Afghan patients with active pulmonary TB were enrolled in the Pulmonary Department of the Pasteur Institute of Iran. Serum and sputum samples were collected simultaneously from all participants. A Real-time PCR was conducted to detect differentially expressed miRNAs. Results: Iranian (P<0.0001) and Afghan (P<0.0001) serum samples and Afghan (P<0.0001) sputum samples overexpressed miR-125a, whereas Iranian sputum samples showed downregulation (P=0.0039). In both Iranian (P<0.0001; P=0.0007) and Afghan (P<0.0001; P<0.0001) serum and sputum samples, miR-125b was overexpressed. Furthermore, miR-let-7f down-regulation was observed in serum and sputum samples (P<0.0001), whereas Iranian sputum samples had no statistically significant differences (P=0.348). Conclusion: Overexpression of miR-125a and miR-125b has been detected in Iranian and Afghan samples. In both races, miR-let-7f downregulation has been confirmed. Identification of miRNA profiles under different conditions opens the door to evaluating potential new biomarkers for diagnosis, disease monitoring, and therapeutic markers in TB infection.
Detection of multi-class arrhythmia using heuristic and deep neural network on edge device

Heart disease is a heart condition that sometimes causes a person to die suddenly. One indication is a rhythm disorder known as arrhythmia. Multi-class Arrhythmia Detection has followed: QRS complex detection procedure and arrhythmia classification based on the QRS complex morphology. We proposed an edge device that detects QRS complexes based on variance analysis (QVAT) and the arrhythmia classification based on the QRS complex spectrogram. The classifier uses two-dimensional convolutional neural network (2D CNN) deep learning. We use a single board computer and neural network compute stick to implement the edge device. The outcomes are a prototype device cardiologists use as a supporting tool for analysing ECG signals, and patients can also use it for self-tests to figure out their heart health. To evaluate the performance of our edge device, we tested using the MIT-BIH database because other methods also use the data. The QVAT sensitivity and predictive positive are 99.81% and 99.90%, respectively. Our classifier's accuracy, sensitivity, predictive positive, specificity, and F1-score are 99.82%, 99.55%, 99.55%, 99.89%, and 99.55%, respectively. The experiment result of arrhythmia classification shows that our method outperforms the others. Still, for r-peak detection, the QVAT implemented in an edge device is comparable to the other methods. In future work, we can improve the performance of r-peak detection using the double-check algorithm in QVAT and cross-check the QRS complex detection by adding 1 class to the classifier, namely the non-QRS class.
Inter-Island Water Crossings by Peary Caribou, South-Central Queen Elizabeth Islands

Satellite and conventional radio telemetry were used to obtain information on daily and seasonal movements of Peary caribou ( Rangifer tarandus pearyi ) on south-central Queen Elizabeth Islands, Northwest Territories, Canada. Seventeen Peary caribou were captured in 1993 and fitted with telemetry neck collars. Seven collars housed both a Satellite Platform Transmitter Terminal package and radio telemetry package; the other 10 collars all housed only the radio telemetry package. Three of the collared caribou, along with at least 16 of their companion animals, made inter-island water crossings by swimming between Ile Vanier and Massey or between Massey Island and Ile Marc in August 1993. Of particular note is that two-month-old calves, as well as adult caribou, were involved in some of the frigid saltwater crossings. The water crossing between Ile Vanier and Massey Island required a minimum straight-line swim of 2.5 km and that between Massey Island and Ile Marc a minimum 1.6 km swim, depending on points of entry and exit from the water. That evidence composes the first documented account of Peary caribou swimming between any of the Queen Elizabeth Islands. Key words: Peary caribou, Queen Elizabeth Islands, Northwest Territories, inter-island summertime water crossings, swimming
Impacto a largo plazo de la Cirugía Bariátrica en la remisión de la Diabetes tipo 2

Introducción: La cirugía bariátrica ha surgido como una estrategia prometedora para abordar la remisión de la diabetes tipo 2, ofreciendo un rayo de esperanza para aquellos que enfrentan este desafío metabólico. Resultados: La cirugía bariátrica/metabólica ha demostrado una mejora sostenida en la remisión de la diabetes tipo 2 a largo plazo. A pesar de que las tasas de remisión disminuyen con el tiempo, la cirugía sigue siendo más efectiva que otras intervenciones médicas o cambios en el estilo de vida. Además, los mecanismos subyacentes a esta mejoría podrían incluir la reducción de la necesidad de medicamentos y mejoras en el control metabólico. Sin embargo, la duración de la diabetes y los cambios de peso a corto plazo no son predictores consistentes de la remisión, mientras que otros factores como el tipo de procedimiento bariátrico y la duración de la enfermedad pueden desempeñar un papel crucial en el pronóstico. Conclusiones: Los hallazgos indican que la cirugía bariátrica tiene un impacto positivo y sostenible en la remisión de la diabetes tipo 2, a pesar de una disminución en las tasas con el tiempo. Esta influencia en la remisión se atribuye a una combinación de factores, incluyendo la pérdida de peso, mejoras en el control metabólico y cambios en marcadores metabólicos.
Individuals with Diabetes Mellitus Have a Dry Eye Phenotype Driven by Low Symptom Burden and Anatomic Abnormalities

Dry eye disease is an umbrella term that includes a variety of symptoms and signs. A link between diabetes mellitus and dry eye disease exists, but the associated phenotype needs further examination. Thus, our aim was to determine how diabetes mellitus relates to the dry eye disease phenotype. A prospective, cross-sectional study was conducted at the Miami Veteran Affairs Medical Center ophthalmology clinic between October 2013 and September 2019. Participants included a volunteer sample of 366 South Florida veterans with one or more symptoms or signs of dry eye disease [Dry Eye Questionnaire-5 ≥ 6 OR tear break-up time ≤ 5 OR Schirmer’s test score ≤ 5 OR corneal fluorescein staining ≥ 2]. Participants were divided into three groups: (1) individuals without diabetes mellitus (controls); (2) individuals with diabetes mellitus but without end-organ complications; and (3) individuals with diabetes mellitus and end-organ complications. Dry eye metrics were compared across groups. The main outcome measures included ocular symptom questionnaires [e.g., 5-item Dry Eye Questionnaire, Ocular Surface Disease Index, and ocular pain assessment] and clinical parameters obtained from an ocular surface evaluation. A total of 366 individuals were included (mean age 59 ± 6 years; 89% males; 39% White; 11% diabetes mellitus and end-organ complications; 15% diabetes mellitus but without end-organ complications). Individuals with diabetes mellitus and end-organ complications had lower symptom scores on the dry eye disease and pain-specific questionnaires compared to individuals with diabetes mellitus but without end-organ complications and controls (Ocular Surface Disease Index: 42.1 ± 24.5 vs. 38.9 ± 25.1 vs. 23.6 ± 16.2; p < 0.001; numerical rating scale of ocular pain intensity: 4.9 ± 3.2 vs. 4.3 ± 2.7 vs. 3.5 ± 2.7; p = 0.02). Eyelid laxity was also more severe in the group with diabetes mellitus and end-organ complications (0.69 ± 0.64 vs. 0.73 ± 0.72 vs. 1.08 ± 0.77; p = 0.004) compared to the two other groups. The diabetic dry eye disease phenotype is driven by signs more so than by symptoms, with anatomic eyelid abnormalities being more frequent in individuals with diabetes mellitus and end-organ complications. Given this, ocular surface abnormalities in individuals with DM may be missed if screened by symptoms alone. As such, individuals with DM should undergo a slit lamp examination for signs of ocular surface disease, including anatomic abnormalities.
Prolactin and vascular disease; a first cautious assessment

Although peripartum cardiomyopathy (PPCM) is a rare disease, it has very serious consequences for both mother and child. No single cause has been held responsible for the pathogenesis. Recent studies have indicated that increased proteolytic cathepsin D activity in cardiomyocytes results in 16 kDa prolactin fragments with anti-angiogenic and apoptotic properties, which may contribute to the development of PPCM. In support of these findings, lowering full-length prolactin production by bromocriptine therapy has been reported to prevent impairment of cardiac function. PPCM is associated with an increased co-existence of preeclampsia, however, a causal relationship has been disputed. We hypothesize that the pathophysiology of PPCM and preeclampsia share the same molecular pathway: increased activity of trophoblastic matrix metalloproteinases at the feto-maternal interface may aggravate proteolysis of full-length prolactin, and subsequently the formed 16 kDa prolactin fragments may contribute to deterioration of PPCM and preeclampsia. Therefore, we argue that it may be worthwhile to explore whether prolactin inhibition is not only beneficial for PPCM patients, but also for the much more prevalent preeclamptic women.
Ambient noise tomography across the Central Andes

We provide a dispersion misﬁt map as well as uncertainty envelopes for our V sv model and observe striking ﬁrst-order correlations with our shallow results ( ∼ 5 km) and the morphotectonic provinces as well as subtler geological features indicating our results are robust. Our results reveal for the ﬁrst time the full extent of the mid-crustal Andean low-velocity zone that we tentatively interpret as the signature of a very large volume Neogene batholith. This study demonstrates the efﬁcacy of integrating seismic data from numerous regional broad-band seismic networks to approximate the high-resolution coverage previously only available though larger networks such as the EarthScope USArray Transportable Array in the United States.
Influence of Debris Cover on Ogive-like Surface Morphology of Bilchenok Glacier in Kamchatka

ABSTRACT Bilchenok Glacier is a surging glacier in the Kamchatka Peninsula, Russia, which most recently surged in 1982 and is currently in its quiescent phase. Field research in 1998 revealed an ogive-like repeated pattern of transverse ridges and intervening gently sloping ice at the surface of the ablation area of this glacier. It was also observed that most of the glacial surface was covered by volcanic rocks and ash, and the debris thickness on the ridges was more than 1 m, whereas the gently sloping ice was covered by thin debris. We posit that the pattern of the debris thickness is caused by the unique conditions of Bilchenok Glacier, namely, the restricted position of its debris supply at the foot of the rock walls beside the icefall and its surging behavior. The distance between the ridges might indicate the total horizontal displacement attributable to surges. The dependence of the ablation rate on the debris thickness can result in a highly undulating ice surface between the ridge and the gently sloping ice. We estimate the effect of the debris thickness on the ice surface profile using a simple model and this model successfully predicts that high ice relief can be caused by different ablation rates in the debris cover thickness.
Extensional salt tectonics in a contractional orogen: A newly identified tectonic event in the Spanish Pyrenees

A new Coniacian–early Santonian extensional salt tectonics event has been identified in the Cotiella thrust sheet of the central Spanish Pyrenees. We present a new interpretation of the Cotiella thrust system and describe exceptional outcrop examples of postrift, gravity-driven extensional growth faults. The thrust sheet contains three, kilometer-scale extensional faults with as much as 5.5 km of Coniacian–lower Santonian growth strata in their hanging walls. These postrift listric growth faults detached on the prerift Triassic evaporites on the uplifted and eroded southern flanks of Early Cretaceous rift basins. Early Alpine (late Santonian–Maastrichtian) contractional deformation reactivated and reversed the displacement on both the Early Cretaceous rift faults and some of the postrift-salt detachment faults. Hanging walls of the listric growth faults deformed into major antiforms, but the original extensional geometries are well preserved. Continued Alpine shortening incorporated these reactivated extensional fault systems into the thin-skinned thrust sheets of the southern Pyrenees. These postrift extensional structures account for significant thickness variations in the postrift succession and for along-strike changes in the styles of the thrust structures. The Late Cretaceous extensional salt tectonics is interpreted to result from gravity-induced northward sliding on the Early Cretaceous rift margin, toward the axis of the rift basin. The listric growth faults are similar to those found on the Gulf of Mexico margin, in the southern North Sea, and the South Atlantic margins.
Elsholtzia ciliata Essential Oil Exhibits a Smooth Muscle Relaxant Effect

A recent in vivo study in pigs demonstrated the hypotensive properties of essential oil extracted from the blossoming plant Elsholtzia ciliata. This study was designed to examine the effect of E. ciliata essential oil (EO) on smooth muscle contraction. Tension measurements were performed on prostate strips and intact aortic rings isolated from rats. Results showed that EO caused a concentration-dependent reduction in phenylephrine-induced contraction of both the prostate and aorta, with a more pronounced inhibitory effect in the prostate. The IC50 of EO for the prostate was 0.24 ± 0.03 µL/mL (n = 10) and for the aorta was 0.72 ± 0.11 µL/mL (n = 4, p < 0.05 vs. prostate). The chromatographic analysis identified elsholtzia ketone (10.64%) and dehydroelsholtzia ketone (86.23%) as the predominant compounds in the tested EO. Since both compounds feature a furan ring within their molecular structure, other furan ring-containing compounds, 2-acetylfuran (2AF) and 5-methylfurfural (5MFF), were examined. For the first time, our study demonstrated the relaxant effects of 2AF and 5MFF on smooth muscles. Further, results showed that EO, 2AF, and 5MFF altered the responsiveness of prostate smooth muscle cells to phenylephrine. Under control conditions, the EC50 of phenylephrine was 0.18 ± 0.03 µM (n = 5), while in the presence of EO, 2AF, or 5MFF, the EC50 values were 0.81 ± 0.3 µM (n = 5), 0.89 ± 0.11 µM (n = 5), and 0.69 ± 0.23 µM (n = 4), respectively, p < 0.05 vs. control. Analysis of the affinity of EO for α1-adrenergic receptors in the prostate suggested that EO at a certain range of concentrations has a competitive antagonistic effect on α1-adrenergic receptors. In conclusion, EO elicits a relaxant effect on smooth muscles which may be related to the inhibition of α1-adrenoreceptors.
Riparian vegetation after dam construction on mountain rivers in China

In order to know the change and the response mechanism of riparian vegetation to hydroelectric dams, three diversion‐type stations on the following mountain rivers, Manyue River, Xiaoyuan River and Baili River, were studied. Plants were investigated in consecutive 1 m2 along three separate 12‐m‐long belt transects that were selected along every 100 m upstream and downstream sections of these rivers. The results showed that, first, 125 plant species that consist of 14 trees, 30 shrubs and 81 herbs in a total of 216 quadrats were recorded. Second, there were significant differences on plant communities (species richness, species cover) amongst rivers, which can also be found in terms of the upstream versus downstream. This suggested that the dams had resulted in changes in riparian plant communities, but differences caused by reservoir were within the natural range of variation found across the rivers. Third, we found the number of some xerophytes and highland plants, such as Cupressus funebris, is significantly increased in downstream of dams and some species that adaptated to tranquil reaches and lakes largely increased in upstream of the dams, such as Azolla imbircata and Polygonum nepalense. This revealed that the construction of dams had changed the riparian habitat, the composition and diversity of riparian plants between downstream and upstream of dams. Integrated operation and management of the whole basin should be taken for the health of river system. Copyright © 2013 John Wiley & Sons, Ltd.
Immobilization of Tyrosinase and Its Application

Immobilized enzymes are more robust and resistant to environmental changes than free enzymes in solution. More crucially, the immobilized enzyme systems' heterogeneity enables facile recovery of enzymes and products, multiple reuses, continuous enzymatic processes, quick reaction termination, and a more comprehensive range of bioreactor designs. This paper examines recent findings on enzyme immobilization using diverse approaches for various uses. The information gathered from the reactions catalyzed by the encapsulated tyrosinase provided a good view of hetero-biocatalysts in the phenol biosensor industries. This review proposes an effective method for immobilizing tyrosinase biomolecules into a silica aerogel matrix. Silica matrix has been utilized to encapsulate a wide range of biomolecules, mainly in sol-gel composites. We also discovered that silica aerogel synthesized from sol-gel method retains all the immobilized enzyme activity. The use of a silica matrix for enzyme immobilization, in conjunction with a moderate immobilization method, results in the successful retention of enzyme activity. Future studies should explore practical encapsulating approaches and inventively modified supports to enhance the commercialization of immobilized enzymes and offer fresh perspectives to the industrial sector.
Global Sea Surface Temperature Forecasts Using a Pairwise Dynamic Combination Approach

AbstractThis paper dynamically combined three multivariate forecasts where spatially and temporally variant combination weights are estimated using a nearest-neighbor approach. The case study presented combines forecasts from three climate models for the period 1958–2001. The variables of interest here are the monthly global sea surface temperature anomalies (SSTA) at a 5° × 5° latitude–longitude grid, predicted 3 months in advance. The forecast from the static weight combination is used as the base case for comparison. The forecasted sea surface temperature using the dynamic combination algorithm offers consistent improvements over the static combination approach for all seasons. This improved skill is achieved over at least 93% of the global grid cells, in four 10-yr independent validation segments. Dynamically combined forecasts reduce the mean-square error of the SSTA by at least 25% for 72% of the global grid cells when compared against the best-performing single forecast among the three climate mode.
Relation Between Grain Size and Correlation Length of Snow

In the past it has often been difficult to compare results of different types of snow-structural information. Grain-size and correlation length are such parameters of granular media, and there exist different definitions and different measurement methods for both of them. The relation between these parameters is analyzed from theoretical and from experimental points of view, considering optical and microwave properties. For spherical ice grains the connecting formulas are simple, but for other shapes the two parameters are not directly related. Care must be taken in the measurement procedure. Especially if grain-size is regarded as the maximum extent of connected ice particles, the results are likely to lead to extreme overestimates. Therefore it is concluded that grain-size should be complemented by an additional size parameter, namely, the surface-to-volume ratio of equivalent spheres, i.e. a measure of the correlation length. Methods to determine this quantity in the laboratory have been known for a long time. Methods to obtain such measurements in the field are described here.
Tipologi Pembaruan Hukum Keluarga Islam di Ghana

This article describes the development of Islamic family law in Ghana, from marriage, polygamy to divorce, as well as the typology in its renewal. Islamic family law has been regulated in Islamic law. However, in practice, the life of the nation and state always requires development and renewal, in line with the changing times, places, times, and conditions. Using historical methods, descriptive in nature, with inductive analysis, and arranged in the form of a narrative that is creative and in-depth. The formulation of the problem is: (1) How is the development of Islamic family law in Ghana? (2) What is the typology of Islamic family law reform in Ghana? The result is that the development of Islamic family law in Ghana was influenced by customary law and colonial law. The typology of reform combines intradoctrinal reform and extradoctrinal reform, which emphasizes rational and contextual considerations to create a modern and just society.