Miracle-dz/UniFAR-FTUs huggingface dataset:
Compassion Focussed Therapy ( CFT )

Compassion has its beginnings in Buddhist tradition, and is a theory that is often championed by the Dalai Lama. In many of his statements he states that if you want people to be happy we must focus on compassion; the same can be said of our own personal happiness. Although there is a long tradition of compassion being considered a healing factor, (Most clinicians agree that it is vital to any therapist-Client relationship) in recent years there has been a push for notions of compassion to consider as a standalone therapy (Gilbert2009).
ARTYKUŁ ORYGINALNY/ORIGINAL PAPER Usefulness of anti-cyclic citrullinated peptide autoantibodies assays in differential diagnosis of polyarthritis

An early stage of rheumatoid arthritis (RA) has frequently an atypical course and it is difficult to differentiate it from other types of polyarthritis. It has been proved, that anti-cyclic citrullinated peptide antibodies (anti-CCP) are highly specific marker for RA. Anti-CCP can be found several years before clinical diagnosis of RA. The aim of the study was a retrospective assessment of usefulness of anti-CCP antibodies in differential diagnosis of polyarthritis. We analyzed case histories of 320 patients (pts) with symptoms of polyarthritis, hospitalized in the Department of Rheumatology and Connective Tissue Diseases between 2003 and 2004. The presence of anti-CCP was determined in all patients by enzyme linked immunosorbent assay (ELISA). The positive measurement was obtained in 165 pts. Further analysis was performed in 124 pts with significantly (20-80 RU/ml) and highly (>80 RU/ml) positive measurements of antibodies. During two years of observation, RA was diagnosed (according to the American College of Rheumatology, ACR, criteria) in 97 pts. A therapy with disease modifying antirheumatic drugs was administered in all the patients. The remaining patients did not fulfill the ACR criteria for RA in our observation period. The following diagnoses were established: in 9 pts other connective tissue diseases (4 pts with undifferential connective tissue disease – UCTD, 3 pts with sysReumatologia 2005; 43, 6: 319–322 Artyku3 oryginalny/Original paper
How far have we achieved by systemic therapy for recurrent/metastatic nasopharyngeal carcinoma?

Nasopharyngeal carcinoma of undifferentiated type is distinctive in terms of radical and geographical distribution, with highest incidence in Southern China, Taiwan and Singapore, followed by North Africa and Alaska. Radiotherapy with contemporary techniques like intensity-modulated radiation therapy is the mainstay of treatment for early-stage disease, while concurrent chemoradiation with or without adjunct chemotherapy is indicated in locoregionally advanced disease (1). Nevertheless, about 30% of patients develop recurrence or metastasis despite intensive radical treatment (2). Though most of these relapsed patients have an unfavorable survival outcome, their survival can be significantly prolonged with palliative chemotherapy.
Artificial Intelligence in Ophthalmology in 2020: A Technology on the Cusp for Translation and Implementation.

W ith aging populations, health systems worldwide are struggling to provide adequate eye care at the population level, giving rise to projections of increasing levels of visual impairment (VI) and blindness from major eye diseases in the near future. The substantial burden of VI has overwhelmed global efforts to expand the physical capacity (eye clinics and hospitals and related facilities) and expert availability of eye care providers (eg, ophthalmologists, optometrists). This trend has been observed even in developed nations. Long waiting times to see an ophthalmologist in public hospitals are common in the United States, UK, Australia, Singapore, and Hong Kong. A study in England reported that a delay in care of 22 weeks resulted in harms such as permanent visual acuity deterioration and visual field loss in some patients that could have been avoided with earlier intervention. This reflects the urgent public health need for completely novel solutions to improve the accessibility and availability of eye care services at primary, secondary, and tertiary level for the larger population. Of the major eye diseases, diabetic retinopathy (DR), age-related macular degeneration (AMD), glaucoma, and cataract are major global causes of blindness. DR has alarming projections for prevalence despite established costeffectiveness and guidelines for population screening. This is partly due to staggering growth in the burden of diabetes mellitus (DM), whereby DR is a common end organ manifestation of DM. Similarly, AMD and glaucoma are other leading causes of VI, driven by aging populations. Gaps in population-level screening and management of DR, AMD, and glaucoma are well known and have not been adequately tackled using traditional models of care, which have largely focused on provision of tertiary level eye care.
Notes On the Taxonomy and Distribution of Two Closely Related Species of Ghost Crabs, Ocypode Sinensis and O. Cordimanus (Decapoda, Brachyura, Ocypodidae)

The identities of two closely related Indo-West Pacific species of ghost crabs, Ocypode sinensis Dai, Song & Yang, 1985, and O. cordimanus Latreille, 1818, are clarified. These two species are different not only in various external characters, but also in the structure of their gastric mills. The distribution of O. sinensis is now extended to include India, Peninsular Malaysia, Taiwan, Japan, and the Philippines.
Signal Left, Turn Right

How have local governments in China been able to break through central policy restrictions in a unitary and authoritarian political system? Why is China’s official discourse in the reform era often so conservative and unfavorable to reform? The author argues the two issues are components of a signaling game between China’s central government and local officials, in which local officials know that the center may be reformist, but the reformist center imitates the rhetoric of a conservative center to control the pace of local liberalization. The result is a gradualist reform of “signaling left, turning right,” with glaring incongruity of speech and actions in the process.
Addition of nivolumab to chemotherapy in patients with advanced gastric cancer: a relevant step ahead, but still many questions to answer

Among the most relevant highlights of the European Society of Medical Oncology (ESMO) 2020 virtual meeting were several important advances for the treatment of gastro-oesophageal cancers, which were presented and discussed at the third presidential session. Two phase III randomised trials studied the addition of Nivolumab to standard chemotherapy in patients with advanced gastro-oesophageal adenocarcinomas, including gastric, junctional and lower third oesophageal locations in the CheckMate649 trial1 and only gastric and junctional locations for the ATTRACTION-4 study.2 In both trials, at least one primary endpoint was met and therefore, we should consider them as positive studies. However, their practical consequences, implying modifications in clinical practice and adoption as standard of care require a careful analysis of all details in both studies. Both studies share a similar design but they also differ in some relevant aspects. CheckMate649 is a global study which accrued patients from all over the world, while ATTRACTION-4 did only so in Japan, Korea and Taiwan. Both had similar stratification factors including tumour cell PD-L1 expression ≥1% vs ≤1% and compared the addition of Nivolumab to conventional platinum-based chemotherapy (CAPOX or FOLFOX for CheckMate649 and CAPOX or S1 plus oxaliplatin for ATTRACTION-4) with the same co-primary end points: centrally assessed progression-free survival (PFS) and overall survival (OS), although for a biomarker selected group only (PD-L1 Combined Positive Score (CPS) ≥5) in CheckMate-649). Nivolumab was able to increase response rate and PFS in both studies. However, OS was only significantly prolonged for patients allocated to the Nivolumab plus chemotherapy …
Metagenomic Analysis of Slovak Bryndza Cheese Using Next-Generation 16S rDNA Amplicon Sequencing

Abstract Knowledge about diversity and taxonomic structure of the microbial population present in traditional fermented foods plays a key role in starter culture selection, safety improvement and quality enhancement of the end product. Aim of this study was to investigate microbial consortia composition in Slovak bryndza cheese. For this purpose, we used culture-independent approach based on 16S rDNA amplicon sequencing using next generation sequencing platform. Results obtained by the analysis of three commercial (produced on industrial scale in winter season) and one traditional (artisanal, most valued, produced in May) Slovak bryndza cheese sample were compared. A diverse prokaryotic microflora composed mostly of the genera Lactococcus, Streptococcus, Lactobacillus, and Enterococcus was identified. Lactococcus lactis subsp. lactis and Lactococcus lactis subsp. cremoris were the dominant taxons in all tested samples. Second most abundant species, detected in all bryndza cheeses, were Lactococcus fujiensis and Lactococcus taiwanensis, independently by two different approaches, using different reference 16S rRNA genes databases (Greengenes and NCBI respectively). They have been detected in bryndza cheese samples in substantial amount for the first time. The narrowest microbial diversity was observed in a sample made with a starter culture from pasteurised milk. Metagenomic analysis by high-throughput sequencing using 16S rRNA genes seems to be a powerful tool for studying the structure of the microbial population in cheeses.
Chinese Herbal Medicine for Symptom Management in Cancer Palliative Care Systematic Review And Meta-analysis

pain, the World Healt opioids, adjuvants, and relief approach. How Editor: Zhenhua He. Received: November 23, 2015; revised: January 5, 2016; accepted: January 19, 2016. From the Hong Kong Institute of Integrative Medicine (VCHC, XW, EPH, AYLL, SYSW, JCYW), The Chinese University of Hong Kong, Hong Kong, China; School of Public Health and Primary Care (VCHC, XW, PL, JZ, MF, SYSW), The Chinese University of Hong Kong, Hong Kong, China; Comprehensive Cancer Trials Unit (EPH), The Chinese University of Hong Kong, Hong Kong, China; Department of Family and Community Medicine (YZ), Texas Tech University, Lubbock; Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), Faculty of Health (YZ, ALZ), University of Technology Sydney, Sydney, Australia; Traditional & Complementary Medicine Research Program (ALZ), School of Health Sciences and Health Innovations Research Institute, RMIT University, Melbourne, Australia; Department of Medicine and Therapeutics (AYLL, JCYW), The Chinese University of Hong Kong, Hong Kong, China; and Chinese Medicine Department (ETCZ, BFLN), Hong Kong Hospital Authority, Hong Kong, China. Correspondence: Xinyin Wu, School of Public Health Building, Prince of Wales Hospital, 5/F, Shatin, New Territories, Hong Kong, China. (e-mail: wuxinyin@cuhk.edu.hk). YZ and ALZ contributed equally to the article. This systematic review was supported by Hospital Authority of Hong Kong (Reference number: 8110016609). VCHC is Honorary Research Fellow of the Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), Faculty of Health, University of Technology Sydney, Sydney, Australia. The remaining authors declare no conflict of interest. Supplemental Digital Content is available for this article. Copyright # 2016 Wolters Kluwer Health, Inc. All rights reserved. This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. ISSN: 0025-7974 DOI: 10.1097/MD.0000000000002793
The Study of Investment Motivation and Managerial Problems of Taiwanese Companies in Cambodia

Due to the increasing competition from China and Southeast Asia countries, many Taiwanese companies have to invest in a foreign country in order to maintain a competitive advantage. However, the risk in foreign investment is much higher than in domestic investment because most of the companies are not familiar with the situation and culture of the foreign country. Therefore, the company has to be caution in making a foreign investment decision. The objective of this study is to investigate the investment motivation and managerial problems of Cambodia’s Taiwanese companies by using the questionnaire method. The methodology used in this study is a questionnaire approach. Totally 46 valid replies from companies were received. The results showed that motivations for more than half of Taiwanese companies are no exchange control and developing market. The major problems faced by Taiwanese companies are: poor administrative efficiency, insufficient infrastructure, insufficient power supply and high cost, difficulty in managing employees due to cultural differences. Hopefully, the result of this study can be used as a reference for Taiwanese companies seeking investment in Cambodia. More updated information is needed in further research to compare the current and earlier situations.
Risk of Osteoporosis in Patients With Atrial Fibrillation Using Non–Vitamin K Antagonist Oral Anticoagulants or Warfarin

Background Warfarin, a vitamin K antagonist, has been shown to affect bone mineral density and cause osteoporosis. However, studies investigating the relationship between non–vitamin K antagonist oral anticoagulants (NOACs) and osteoporosis are limited. We thus compared the risk of osteoporosis in patients with atrial fibrillation treated with either NOACs or warfarin. Methods and Results This nationwide, retrospective cohort study used Taiwan's National Health Insurance Research Database. All adult patients in Taiwan who were newly diagnosed with atrial fibrillation and treated with NOACs or warfarin between January 2012 and December 2015 were included and classified into their respective cohorts. Patients who received NOACs were subcategorized into the rivaroxaban, dabigatran, and apixaban subgroups. Propensity score matching was performed for each head‐to‐head comparison. Adjusted hazard ratios (aHRs) for the risk of osteoporosis were calculated using Cox proportional hazards regression models, with adjustment for confounders. Overall, 17 008 patients were included, with 8504 in each cohort. NOACs were associated with a lower osteoporosis risk than warfarin (aHR=0.82; 95% CI=0.68–0.97). A subgroup effect of treatment duration was identified (namely, the lower osteoporosis risk with NOAC compared with warfarin became stronger in those with longer treatment duration [P for interaction <0.001]). Furthermore, significantly lower risks of osteoporosis were observed in the rivaroxaban (aHR=0.68; 95% CI=0.55–0.83) and apixaban (aHR=0.38; 95% CI=0.22–0.66) subgroups, but not in the dabigatran subgroup (aHR=1.04; 95% CI=0.85–1.27). Conclusions Compared with warfarin, rivaroxaban and apixaban were associated with a significantly lower risk of osteoporosis in patients with atrial fibrillation.
[Preliminary. Do not circulate without permission.] How much do tax-benefit policies of East Asian countries equalize opportunities among their citizens?

Employing the method of Roemer et al. (2003), the present paper studies the extent to which tax-benefit policies of three East Asian countries – Korea, Japan, and Taiwan – equalize opportunities among their citizens for income acquisition. According to Roemer et al. (2003), equality of opportunity for income acquisition is achieved in a country when it is the case that the distributions of post-fisc income are the same for different types of citizens in that country, where a citizen’s type is defined by the socio-economic status of his/her parents. We classify types according to the level of parents’ education. In terms of the optimal tax rates required for equalizing opportunities for income acquisition among citizens, the level of unequal opportunity in Korea and Taiwan are found to be similar to those of Spain, Italy, and the United States reported in Roemer et al. (2003). The observed tax rates in these countries are, however, lower than those of the aforementioned three countries, and there are very large differences between the optimal and the observed tax rates. This implies that the tax-benefit policies of Korea and Taiwan have played very little role in correcting unequal opportunities for income acquisition among their citizens. Japan is different; the EOp tax rate is less than the observed tax rate or equal to zero. This is because the individuals classified as the least advantaged type in Japan are much better off than those in Korea and Taiwan, due to data availability. Our analysis also implies that relatively equal distribution of outcomes in East Asian countries is not due to small variation in outcomes across types, but perhaps due to small variation in outcomes across effort levels in each type.
Molecular characterization of the CP gene and 3'UTR of Chilli veinal mottle virus from South and Southeast Asia

Twenty-four isolates of Chilli veinal mottle virus (ChiVMV) from China, India, Indonesia, Taiwan and Thailand were analysed to determine their genetic relatedness. Pathogenicity of virus isolates was confirmed by induction of systemic mosaic and/or necrotic ringspot symptoms on Capsicum annuum after mechanical inoculation. The 3′ terminal sequences of the viral genomic RNA were determined. The coat protein (CP) coding regions ranged from 858 to 864 nucleotides and the 3′ untranslated regions (3′UTR) from 275 to 289 nucleotides in length. All isolates had the inverted repeat sequence GUGGNNNCCAC in the 3′UTR. The DAG motif, conserved in aphid-transmitted potyviruses, was observed in all isolates. All 24 isolates were considered as belonging to ChiVMV because of their high CP amino acid and nucleotide identity (more than 94·8 and 89·5%, respectively) with the reported ChiVMV isolates including the pepper vein banding virus (PVBV), the chilli vein-banding mottle virus (CVbMV) and the CVbMV Chiengmai isolate (CVbMV-CM1). Based on phylogenetic analysis, ChiVMV isolates including all 24 isolates tested, PVBV, CVbMV and CVbMV-CM1 can be classified into three groups. In addition, a conserved region of 204 amino acids with more than 90·2% identity was identified in the C terminal of the CP gene of ChiVMV and Pepper veinal mottle virus (PVMV), and may explain the serological cross reaction between these two viruses. The conserved region may also provide useful information for developing transgenic resistance to both ChiVMV and PVMV.
Qualitative analysis of food spectrum of five species of anuran tadpoles from Arunachal Pradesh, India

514 Received 29 December 2000 Accepted 17 March 2001 Abstract Anuran tadpoles were collected from amphibian habitats of Arunachal Pradesh during the breeding season from March to September. Taxonomic identification of the tadpoles was done with the help of existing literature (Sahu, 1981). Gut content analysis of five species of tadpoles was done to know the food consumed. Tadpoles between stage 30 to 38 (Gosner, 1960) were selected for the study. Bufo melanostictus, Amolops afghanus, Euphlyctis cyanophlyctis, Rana danieli and Rhacophorus maximus were studied. This is the first study on food habit of tadpoles in Arunachal Pradesh and will help in the study of habitat deterioration and floristic composition of amphibian habitats in future.
Production of Japanese Horseradish (Wasabia japonica (Miq.) Matsumara) in Poland. Chemical Contents of Roots

Japanese horseradish [Wasabia japonica (Miq.) Matsumara or Eutrema wasabi (Siebold) Maxim. ], is a vegetable species originated from Japan. Currently, wasabi is grown in many other countries across the world such as: New Zealand, Taiwan, South Korea, Israel, Brazil, Thailand, Columbia, Canada, USA, Great Britain and China. The crop has never been cultivated commercially in Poland. The main aim of the present study was to find out if the crop can be grown commercially in Poland and to establish the chemical contents of roots produced in Poland and Japan. In previous studies, it was noted that wasabi might be grown under polycarbonate cover in Poland. The chemical evaluation included measuring the amount of dry matter, polyphenols, antioxidant potential, reducing substances, total proteins, starch and raw fiber. The roots produced in Poland had more dry matter (30.46%), less total proteins (12.14%) and reducing substances (43.64 mg g-1) than the Japanese ones. Starch and raw fiber contents were on the same level in the roots produced in both countries. The antioxidant potential and polyphenols in the Japanese roots (6.11 mg g-1 and 7.83 mg g-1 respectively)were higher than in the Polish ones (1.45 mg g-1 and 3.25 mg g-1 respectively). In the climatic conditions of Poland, it might be possible to produce wasabi roots under the polycarbonate cover with their chemical contents at least in part similar to the original roots produced in Japan.
Optimization of extracellular thermophilic highly alkaline lipase from thermophilic bacillus sp isolated from hotspring of Arunachal Pradesh, India

Studies on lipase production were carried out with a bacterial strain (Bacillus sp LBN 2) isolated from soil sample of hotspring of Arunachal Pradesh, India. The cells were cultivated in a mineral medium with maximum production at 1% groundnut oil. The optimum temperature and initial medium pH for lipase production by the organism were 500C and 9.0 respectively. The molecular mass was found to be 33KDa by SDS PAGE. The optimal pH and temperature for activity were 10 and 600C respectively. The enzyme was found to be stable in the pH range of 8–11 with 90% retention of activity at pH 11. The enzyme retained 90% activity at 600C and 70% of activity at 700C for 1h. The lipase was found to be stable in acetone followed by ethanol. The present findings suggested the enzyme to be thermophilic alkaline lipase.
Southeast Asian islands and Oceania: human genetics

The Neolithic period was a time of great change in island Southeast Asia and Oceania. Many characteristics of the peoples living in this region today have their foundation in the Neolithic, including their languages, modes of subsistence, and many aspects of modern culture. The same is true of their biology. The Neolithic period saw major population movements from mainland Asia, substantially changing the biological makeup of communities in what are today the island nations of Taiwan, the Philippines, Indonesia, Papua New Guinea, and Solomon Islands. Descendants of these Neolithic voyagers ultimately developed the advanced seafaring skills necessary to explore and settle the remote islands of the vast Pacific Ocean.