Miracle-dz/UniFAR-FTUs huggingface dataset:
Remoção de agrotóxicos por biorreator de membrana e carvão ativado em efluente industrial

Este estudo teve como objetivo avaliar o potencial de um biorreator de membrana (MBR) piloto para a remoção de agrotóxicos, de formas individual e aliada com o uso de carvão ativado em pó (CAP). A estabilidade do MBR foi monitorada por meio dos parâmetros DQO, pH, SST e permeabilidade. A adição de agrotóxicos foi programada para gerar concentrações de 20 µg.L-1 de 2,4-D, carbendazim e diuron e 1,5 µg.L-1 de atrazina no biorreator. A remoção de agrotóxicos pelo MBR foi avaliada mediante quatro experimentos com variações de TDH (20 e 25 h) e adição de 0,5 g.L-1 de CAP. O MBR demonstrou robustez e estabilidade ao manter a qualidade do permeado mesmo sob elevadas variações de DQO e teor de biomassa. Contudo, promoveu apenas uma remoção parcial dos agrotóxicos estudados. O CAP otimizou a eficácia do sistema; no entanto, foi observada uma perda gradual das eficiências com o tempo, o que destaca a necessidade de mais estudos acerca da duração e da confiabilidade deste material. Palavras-chave: 2,4-D. Atrazina. Carbendazim. Diuron. Pesticidas.
Rate of Multiple Viral and Bacterial CoInfection(s) in Influenza A/H9N2–Infected Broiler Flocks

SUMMARY. Repeated cases of low pathogenic influenza A/H9N2 virus (IAV/H9N2) have been reported in commercial chickens since its emergence in 1998 in Pakistan. However, recently increased mortality and severe respiratory complications under field conditions have been noticed, suggesting concomitant influenza infections with respiratory viral and/or bacterial pathogens. Therefore, the present study aimed to investigate the presence of IAV/H9N2 coinfecting with multiple viral and bacterial pathogens in broiler chicken flocks. We surveyed 60 broiler flocks with respiratory signs from March through July 2019 in Punjab, Pakistan. Suspected flocks were screened for the presence of IAV using a lateral-flow device. Tracheal, cloacal, and bone marrow samples were collected and further tested for seven viral agents (chicken anemia; Newcastle disease; infectious bronchitis; infectious laryngeotracheitis [ILT]; and IAV subtypes H9, H7, and H5) and three bacterial agents (Mycoplasma gallisepticum; Mycoplasma synovae; Ornithobacterium rhinotracheale [ORT]) using PCR assays. Upon initial screening for IAV, 35/60 (58.3%) flocks tested positive. The coinfection of IAV/H9N2 with other pathogens was detected in 25 (71.4%) flocks and only IAV/H9N2 was detected in 10 (28.6%) flocks out of total positive IAV flocks (n = 35). IAV subtypes H5 and H7, ILT, and ORT were not detected throughout the study period. The detection rate of double, triple, and quadruple combinations of coinfections with IAV/H9N2 were 37% (13 flocks), 26% (9 flocks), 9% (3 flocks), respectively. Higher average mortality (28.5%) was found in broiler chicken flocks coinfected with viral and/or bacterial pathogens than in flocks where only H9 low pathogenic IAV/H9N2 was detected (20.8%). In conclusion, higher circulation of IAV/H9N2 with other viral and bacterial pathogens may contribute to higher production and economic losses at the farm level.
Systemic Therapy De-Escalation in Early-Stage Triple-Negative Breast Cancer: Dawn of a New Era?

Simple Summary Triple-negative breast cancer is a life-threatening disease, even when identified at early stages. Recent advances have allowed the improvement of life expectancy via a personalized approach with the addition of newer chemotherapies, immunotherapies, and targeted therapies, but at the cost of added side effects. It has become increasingly clear that not all patients need such aggressive treatment. Here, we provide an overview of emerging opportunities to use less toxic therapies in patients at lower risk of recurrence or with mutations that can be effectively targeted using novel approaches. We provide a comprehensive review of completed and ongoing clinical trials with information on how to best stratify these patients for treatments to obtain maximum benefit without unnecessary toxicities. Abstract Early-stage triple negative breast cancer (TNBC) has been traditionally treated with surgery, radiation, and chemotherapy. The current standard of care systemic treatment of early-stage II and III TNBC involves the use of anthracycline-cyclophosphamide and carboplatin-paclitaxel with pembrolizumab in the neoadjuvant setting followed by adjuvant pembrolizumab per KEYNOTE-522. It is increasingly clear that not all patients with early-stage TNBC need this intensive treatment, thus paving the way for exploring opportunities for regimen de-escalation in selected subgroups. For T1a tumors (≤5 mm), chemotherapy is not used, and for tumors 6–10 mm (T1b) in size with negative lymph nodes, retrospective studies have failed to show a significant benefit with chemotherapy. In low-risk patients, anthracycline-free chemotherapy may be as effective as conventional therapy, as shown in some studies where replacing anthracyclines with carboplatin has shown non-inferior results for pathological complete response (pCR), which may form the backbone of future combination therapies. Recent advances in our understanding of TNBC heterogeneity, mutations, and surrogate markers of response such as pCR have enabled the development of multiple treatment options in the (neo)adjuvant setting in order to de-escalate treatment. These de-escalation studies based on tumor mutational status, such as using Poly ADP-ribose polymerase inhibitors (PARPi) in patients with BRCA mutations, and new immunotherapies such as PD1 blockade, have shown a promising impact on pCR. In addition, the investigational use of (bio)markers, such as high levels of tumor-infiltrating lymphocytes (TILs), low levels of tumor-associated macrophages (TAMs), and complete remission on imaging, also look promising. In this review, we cover the current standard of care systemic treatment of early TNBC and review the opportunities for treatment de-escalation based on clinical risk factors, biomarkers, mutational status, and molecular subtype.
An overview of Large-Eddy Simulation for wind loading on slender structures

Understanding and predicting the effects of wind loading on a structure is necessary for a safe, effective, and economical engineering design. Wind tunnel techniques are expensive and often provide data that is not sufficiently detailed for the structural engineer. With increasing advances in computational capabilities, it has recently become feasible to investigate these flows using numerical techniques. Of these, one of the most effective approaches to simulate the turbulence observed in natural wind is Large-Eddy Simulation (LES). The application of LES to analyse wind loading, and aeroelastic effects on structures are only a recent venture in the field. This paper reviews the progress made over the last few decades for the analysis of wind flow around slender structures, and the more recent analysis incorporating the effects of freestream turbulence. Firstly, a review of the literature for generating freestream turbulence is carried out, and are assessed based on their flaws and strengths. A number of these are subsequently used for the analysis of surface pressures on an isolated tall model building. Subsequently, a review is made into wind tunnel analysis and LES for the aeroelastic analysis of bridge sections. The recent advances in the understanding of turbulence effects on the aeroestatic responses are summarised. The future of LES and its relationship wind tunnel analysis for wind loading analysis are discussed.
Energy consumption of the hydrogen separation process from a mixture with natural gas

The importance of energy storage methods increases in the global energy industry. One of such methods is the production/generation of hydrogen and its further use called power-to-gas technology. Without highly efficient, reliable and cheap energy storage solutions, the energy sector, especially in Poland, may face significant problems related to climate protection and reduction of greenhouse gas emissions to the atmosphere in the nearest future. One alternative way to store and transport hydrogen is to blend small amounts of hydrogen (up to about 15%) into existing natural gas net-works. When hydrogen is required, it can be separated near end-users using separation membranes. The paper presents the possibilities of using membrane technology in the process of obtaining hydrogen as fuel after its storage. The membrane separation technology can be used to separate mixtures of various gases, such as H 2 , O 2 , CO, CO 2 , or CH 4 . The paper presents selected problems of the analysis of the hydrogen separation process from a mixture with natural gas for polymeric membranes with different separation properties. The structure of the separation system has been selected in order to obtain the appropriate purity of the separated gas. The energy consumption of the process of hydrogen separation from a mixture with natural gas was determined for such a system.
Sp1 S-Sulfhydration Induced by Hydrogen Sulfide Inhibits Inflammation via HDAC6/MyD88/NF-κB Signaling Pathway in Adjuvant-Induced Arthritis

Histone deacetylase 6 (HDAC6) acts as a regulator of the nuclear factor kappa-B (NF-κB) signaling pathway by deacetylating the non-histone protein myeloid differentiation primary response 88 (MyD88) at lysine residues, which is an adapter protein for the Toll-like receptor (TLR) and interleukin (IL)-1β receptor. Over-activated immune responses, induced by infiltrated immune cells, excessively trigger the NF-κB signaling pathway in other effector cells and contribute to the development of rheumatoid arthritis (RA). It has also been reported that HDAC6 can promote the activation of the NF-κB signaling pathway. In the present study, we showed that HDAC6 protein level was increased in the synovium tissues of adjuvant-induced arthritis rats. In addition, hydrogen sulfide (H2S) donor S-propargyl-cysteine (SPRC) can inhibit HDAC6 expression and alleviate inflammatory response in vivo. In vitro study revealed that HDAC6 overexpression activated the NF-κB signaling pathway by deacetylating MyD88. Meanwhile, sodium hydrosulfide (NaHS) or HDAC6 inhibitor tubastatin A (tubA) suppressed the pro-inflammatory function of HDAC6. Furthermore, the reduced expression of HDAC6 appeared to result from transcriptional inhibition by S-sulfhydrating specificity protein 1 (Sp1), which is a transcription factor of HDAC6. Our results demonstrate that Sp1 can regulate HDAC6 expression, and S-sulfhydration of Sp1 by antioxidant molecular H2S ameliorates RA progression via the HDAC6/MyD88/NF-κB signaling pathway.
Flow management and its impacts on operational performance

Abstract Based on the organisational capability perspective and the concept of flow management, this study examines the inter-relationships between the management of five flows (human, information, decision, logistics and production flows) and their effects on operational performance. The research model was empirically tested using data from 321 Australian companies. The results show that human flow management (HFM) has a positive effect on the management of the other four flows. Further, information flow management (IFM) is positively associated with logistics flow management (LFM), whereas decision flow management (DFM) is positively associated with both production flow management (PFM) and LFM. The results also show that HFM, PFM and LFM can improve operational performance directly, whereas IFM and DFM only enhance operational performance indirectly. Our findings contribute to flow management theories and practices.
Real-Time Marketing

W obecnych warunkach intensywnego rozwoju nowoczesnych technologii funkcjonowanie przedsiebiorstw zyskalo nowe cechy i mozliwości. Technologie obliczeniowe i elektronicznej wymiany informacji wielorako wplywają na sposoby dzialania firm. Z jednej strony stanowią narzedzia pomocne do usprawniania pracy przedsiebiorstw, z drugiej zaś mogą byc podstawą do tworzenia nowych przedsiewziec biznesowych. Wnioski zawarte w monografii ukazują koniecznośc poglebiania wiedzy na temat zastosowania nowych technologii w zarządzaniu przedsiebiorstwem na wielu polach jego dzialalności. Uświadomienie sobie szans i zagrozen, ktore pojawiają sie wraz z nimi zwieksza mozliwości firm w walce konkurencyjnej.
UALL conference 21 - 22 March 2005 Theme - Widening participation Assessment and Evaluation in Work Based Learning

Research and development carried out at the Centre for Outcomes-Based Education, has provided new ways of enabling students at the Open University to be accredited at higher education level for their learning in the workplace and their prior experiential learning. One of our approaches to the assessment of work-based learning involves recognising the learning that has taken place in National Qualifications Framework (NQF) level 3 qualifications, such as National Vocational Qualifications (NVQ), and enabling students to achieve 30 credits at higher education level through specially designed assessment. The assessment strategy is based on the mapping of learning outcomes from relevant NQF level 3 qualifications onto the generic learning outcomes for 30 credits of work-based learning at higher education level. When this process has been completed, the unmapped learning outcomes can be identified and the assessment strategy can be developed to ensure that students qualify for the full 30 credits at HE level 1. This route into undergraduate study was developed following our research into various employment sectors which highlighted a need to build a pathway between sub-HE and HE learning as a way of encouraging widening participation at university level. Built into this assessment strategy is a support strand which guides students through their studies so that they are well placed to successfully complete this 'conversion' course. Successful completion will enable the individual to be confident about their own skills both in the workplace and at their ability to study at higher education level. This learning and teaching strategy is based on the theory of self-efficacy put forward by theorists such as Dweck, 1999; and Bandura, 1997. Students who have completed this course will therefore be in a good position to further their studies at this higher level.
The Role of Religious Faith in Financial Exclusion

Issue: Jan-Feb 2021 Financial inclusion may be thought of at two levels: having a bank account, reflecting access to banks and financial literacy; and financial deepening, as reflected in operating interest-bearing deposit or loan accounts. As a sizable proportion of the Muslims in the country subscribes to the belief that ‘Riba is Haram’, such religious prohibition to subscribe to interest-bearing banking products may lead to exclusion from financial deepening. While many countries have overcome this deficiency by hosting Islamic banking in their conventional banking systems, India is an exception. The objective of this paper is to examine the prevalence of financial exclusion owing to religious faith in India. A careful analysis of district-level data on deposit accounts, and population census data on urbanization and religious composition, suggests exclusion of Muslims from financial deepening. Regression analysis confirms that faith-based financial exclusion is significant in many states of India. A few private initiatives of recent years to offer interest-free banking services have attracted a large clientele, indicating unmet demand. The lack of a policy response means denying financial inclusion for large segments of population.
Design of Single-User-Mode Computer-Based Examination System for Senior Secondary Schools in Onitsha North Local Government Area of Anambra State, Nigeria

Computer-Based System for in Onitsha Abstract This work is concerned with the design of a single-user-mode computer-based examination system. It focused on trends in online computer-based examination and carried out a critical review of current paper-based test systems employed in Senior Secondary Schools in Nigeria. An alternative system to provide solutions to the current challenges identified in the existing system was then proposed. The system was designed using the object SSADM methodology and implemented using rapid PHP IDE on a Windows 10 system, using PHP, HTML, CSS and MySQL technologies and Apache server as the application server. Source Code folder for the designed CBT system is available at https://villagemath.net/journals/ver/v3i1/ABAH-HONMANE-AGE-OGBULE-CBT.zip with the Installation Guide and Setup information provided in Appendix A. Ayo et al. (2007) proposed a model for e-Examination in Nigeria where all applicants are subjected to online entrance examination as a way of curbing the irregularities as proposed by the Joint Admissions Matriculation Board (JAMB), the body saddled with the responsibility of conducting entrance examinations into all the Nigerian universities. This model was designed and tested in Covenant University, one of the private universities in Nigeria. Their findings revealed that the system has the potentials to eliminate some of the problems that are associated with the traditional methods of examination such as impersonation and other forms of examination malpractices. The model was later adopted for use by Covenant University and JAMB for its computer based examination paving way for a seamless transition from the PPT form of examination. A study by Ayo (2007) on Nigerian University stated that 81.3% of the applicants were computer literate, while the remaining 18.7% were guided through the examination. The total number 1023 (75.7%) of respondents who participated in the e-examination conducted in Covenant University took electronic examination for the first time and as such found the examination easy, a few found it a little challenging but adjusted with time. The study revealed that only 327 (24.2%) of the applicants had not been involved in any form of electronic examination before, and found it difficult. While the system developed in the study is web based, the present work seeks to develop a system that can function without network interference and cheaper to set up and maintain since it is targeted at secondary schools while does not have the same financial weight like the government agencies and higher institutions which the model of the study by Ayo et al. was aimed at. speed and performances differences fifty-five MCQs
Experimental Investigation on Strengthening of Soft Clay Brick Masonry Columns under Compression with Fiber-Reinforced Inorganic and Organic Matrixes

Masonry made with soft clay brick is commonly used in gravity load bearing of construction in India. The masonry piers and walls typically fail by vertical splitting. The purpose of this study is to improve the strength of masonry columns under compression using wrapping for additional confinement. The compressive load carrying performance and capacity of masonry columns wrapped with fiber reinforced composites in organic and inorganic matrixes are compared. For the purpose of overall improvements in cost and durability, glass and basalt fiber reinforcement is used. 30-40% improvement in the compressive performance of masonry prisms was achieved for both Organic and Inorganic matrixes. However, the specimens with inorganic matrixes were found to exhibit higher ductility compared to organic matrixes. Glass fibers were found to be more effective in wrapping masonry specimens compared to Basalt fiber specimens owing to its higher fiber count per unit length. Analytical models for predicting the compressive capacity of masonry columns with wrapping are verified against the experimental results.
2-D Orthogonal Multibeam Antenna Arrays for 5G Millimeter-Wave Applications

In this article, a 2-D $16 \times 16$ Butler matrix-based passive multibeam antenna array (MBAA) and a 2-D active–passive hybrid MBAA (APHMBAA) are both presented for fifth-generation (5G) millimeter-wave (mmWave) applications, which demonstrate that a 2-D coverage can be achieved by two types of 1-D beamformers in two orthogonal planes at analog beamforming level. For the 2-D passive MBAA (PMBAA), the 16 beams are controlled by two stages of substrate integrated waveguide (SIW) Butler matrices placed orthogonally. A novel 2-D interconnection method for connecting these two-stage Butler matrices is implemented based on the flexibility of the SIW without any connectors, cables, and soldering operations and then possesses the advantages of low cost, extensible, and integrated easily in the mmWave bands. The measured results exhibit that the operating bandwidth is 15.38% for the single-stage Butler matrix-based antenna array. Meanwhile, the maximal beam gain of the 2-D PMBAA is 9.4 dBi and its accurate beam directivity is also observed. For the 2-D APHMBAA, the multiple beams are generated by the Butler matrix-based passive beamformers in the vertical direction, whereas the beamforming on the horizontal direction is realized by the active networks utilizing mmWave active beamformer chips. Compared to the proposed 2-D PMBAA, the horizontal scanning performance of the hybrid framework is more flexible. What is more, its costs and complexity are both reduced tempestuously in comparison with an active multibeam array. The measured results show that the maximum measured beam gain of the array is 10.9 dBi and the chip channel gain is 27 dB. A wide 2-D spatial angle is covered simultaneously by the proposed hybrid beamforming scheme.
In Vitro Antimicrobial Potential of CAPE and Caffeamide Derivatives against Oral Microbes

Caffeic acid phenethyl ester (CAPE) is a natural component isolated from propolis and used in traditional medicine. We aimed to investigate the antimicrobial properties and action mechanism of CAPE and caffeamide derivatives (26G and 36M) against oral disease microbes. We resolved the minimum inhibitory and bactericidal concentrations of 26G and 36M and their stability at different temperatures and pH. We also evaluated their effect on biofilm formation and antibiotic resistance gene expression in methicillin-resistant Staphylococcus aureus (MRSA). Our results revealed that 26G and 36M showed the best anticancer and antimicrobial activities, respectively, compared with the other four caffeamide derivatives. Both 26G and 36M showed heat-dependent decreases in antimicrobial activity. The 36M derivative was stable irrespective of pH, whereas 26G was not stable under high pH conditions. Biofilm formation and antibiotic resistance-related gene expression were consistent with their respective phenotypes. This study provides evidence for the potential application of CAPE and caffeamide derivatives in dental medicine to cure or prevent oral diseases.
Joint wall clutter mitigation and data-driven model for through-wall detection

ABSTRACT Wall effects such as the strong front wall return and the propagation of the signal as it travels through the wall must be taken into account in through-wall detection. First of all, compensation of through-wall propagation effects such as attenuation and dispersion should be considered in imaging procedure assuming effective removal of the strong front wall return (called wall clutter). However, the wave backscattered from the target behind the wall is usually submerged in the wall clutter. In addition, the wall parameters are unknown in practical situation. Therefore, how to detect a target behind the wall without prior knowledge of wall characteristics is becoming a new challenge that is difficult to solve. In this article, a novel method jointing wall clutter mitigation and data-driven model (DDM) is proposed to address this new challenge. First, the total echo is decomposed into wall, target, and noise subspaces using singular value decomposition (SVD), while the image entropy is introduced as an evaluation criterion for selecting the sub-spaces boundary, and therefore the wall clutter is mitigated. Then, through-wall detection problem is cast as a regression one using DDM model and the regression problem is solved by means of Support Vector Machine (SVM). It is demonstrated that the proposed method can efficiently detect the target behind the wall without prior knowledge of its characteristics.