Miracle-dz/UniFAR-FTUs huggingface dataset:
Triggered Escalating Real-Time Adherence Intervention to Promote Rapid HIV Viral Suppression Among Youth Living With HIV Failing Antiretroviral Therapy: Protocol for a Triggered Escalating Real-Time Adherence Intervention (Preprint)

BACKGROUND Youth living with HIV (YLWH) are confronted with many self-care challenges that can be experienced as overwhelming in the context of normal developmental processes that characterize adolescence and young adulthood. A sizable minority of YLWH have unsuppressed viral loads in the United States attributable to antiretroviral therapy (ART) nonadherence. Interventions to promote sustained viral suppression in YLWH are needed. OBJECTIVE The aim of this study is to evaluate the efficacy of the Triggered Escalating Real-Time Adherence (TERA) intervention in comparison with standard of care (SOC) in YLWH (aged 13-24 years) failing ART on (1) primary outcome measures—HIV viral suppression (VLS), defined as both <200 copies/ml and <50 copies/ml at 12 weeks, and (2) secondary outcome measures—VLS rates and rates of ART adherence at 24, 36, and 48 weeks as well as patterns of adherence over time as measured by an electronic dose monitoring (EDM) device. METHODS The TERA study is a phase 2, multisite clinical trial conducted with 120 YLWH failing ART (randomized 1:1 to TERA or SOC) at participating clinical sites within the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN). Participants are followed for a total of 48 weeks. For TERA arm participants, the first 12 weeks involve delivery of the intervention. For all participants, clinical outcomes are collected throughout follow-up, and adherence is assessed using EDM over the full 48 weeks. During the 12-week intervention period, TERA arm participants receive 3 remote coaching sessions delivered in clinic via videoconferencing timed to coincide with baseline and follow-up clinical visits, text message reminders when the EDM has not been opened at dose time (which escalate to 2-way theory-informed short message service coaching interactions in response to real-time nonadherence), and review of dosing graphs produced by EDM at follow-up visits. RESULTS Launch dates for enrollment varied by site. Enrollment began in April 2018 and is expected to be completed by August 2019, with results presented by the second quarter of 2021. CONCLUSIONS Effective, generalizable, and scalable approaches to rapidly assist YLWH failing to achieve and sustain VLS may have a substantial impact on individual health and efforts to curb transmission. Coaching for a brief but intensive period from remote coaches and using communication channels common to youth may offer multiple unique advantages in promoting self-care. CLINICALTRIAL ClinicalTrials.gov NCT03292432; https://clinicaltrials.gov/ct2/show/NCT03292432 (Archived by WebCite at http://www.webcitation.org/768J8ijjp). INTERNATIONAL REGISTERED REPOR DERR1-10.2196/11416
Comprehending the Pricing Decision of Online Car-Hailing Services in China: Price Regulation Vs Entry Limitation

Online car-hailing service has had an exponential growth in recent years, and poses a substantial threat to taxi service. Yet how to regulate online car-hailing service has not been adequately studied. Based on the regulation of tradition taxi service, price regulation and entry limitation are used to regulate online car-hailing service in this paper. Moreover, we consider two types of online car-hailing service, i.e., high-end service(e.g. UberBlack) and low-end service (e.g., UberX), according to the perceived service level. Then, the optimal platform’s price is formulated. The result shows that the price regulation are likely to increase the optimal platform price, depending on the service type and the taxi price. When the platform offers low-end service and the taxi price is low, the optimal platform price does not change. In contrast, the entry limitation reduces the optimal platform’s price when it achieves the regulation target.
Does Quality Pay

An empirical study of the automotive supplier industry in Europe and Japan uncovers wide differences in management practice -- and in results DESPITE FREQUENT EFFORTS to estimate the general effect of quality programs on corporate performance, managers have rarely tried to document the connection between specific actions and specific results. That attention to quality pays has become, for the most part, an article of nearly scriptural faith. What exact kind of attention, however, and what exact form and magnitude of payment -- questions of this sort have usually been left among the apocrypha. To help answer such questions as these, McKinsey, together with the Technical University of Darmstadt in Germany, undertook a detailed study of the quality practices of automotive industry suppliers in both Europe and Japan. A breakdown of the companies studied follows. To identify the key success factors of quality management, we grouped the companies in our sample by two measures: a "process quality indicator" (PQI) and a "design quality indicator" (DQI). We defined process quality according to industry-wide, clearly quantifiable measures, both internal and external, which we calculated for each company so as to take into account the complexities of different processes and products. Because no corresponding measures exist for design quality, we developed a scoring system to assess each company's quality goals, as well as the tools that it used in the design phase. This helped us understand its ability to design products that meet customer needs and to produce them with low defect rates. We then used PQI and DQI to arrive at a comprehensive view of total quality. The combination of these rankings resulted in four different performance clusters, which we refer to as the phases of quality management. Impact of quality By analyzing these performance clusters, we discovered four different -- and progressive -- levels of quality management, each of which has a corresponding management approach: Phase I: Inspection. An inspection department is responsible for product control, mainly at the end of the process. Phase II: Assurance. The production department strives for better understanding of -- and control over -- the production process, using tools such as statistical process control (SPC). These companies have begun to orient themselves toward zero defects. Phase III: Prevention. Trying to "design to zero defects," Phase III companies encourage intense cross-functional cooperation, especially between RD design quality, sales growth. …
Wideband Antenna Development.

Abstract : A pair of wideband antennas was designed, fabricated and tested. The transmit antenna and the receive antenna are eight (8) ft paraboloidal reflectors with open horn feeds. The system can transmit and receive a 200 ps wide baseband pulse with a gain-aperture of 200 sq m, good fidelity, and time sidelobes below 25 db. These antennas are the first practical high gain, short pulse experimental models ever constructed. (Author)
Arm movements during slipping

Slip-initiated falls often cause injury and death, especially in older adults. Previous research involving perturbed walking has to a large extent focused on lower extremity reactions, yet arm responses are often part of postural reactions to such perturbations. This research is focused on arm responses to an unexpected slip. In Aim 1, the relationship between slip severity and shoulder biomechanics was examined. In Aim 2, we determined if the vestibular system is involved in the triggering of arm responses. The correlation between shoulder moment magnitude and the extent of the body center of mass (COM) perturbation was examined in Aim 3.Subjects (17 younger and 12 older adults) were exposed to two conditions: (1) baseline dry (subjects knew the floor was dry), and (2) unexpected slip (a diluted glycerol solution was spread on the floor beneath the stance/left foot). Shoulder Euler angles and moments in flexion/extension and abduction/adduction were derived. The spherical elevation angle was used to further describe shoulder kinematics. Slip severity was quantified using measures reported in the literature.Although arm responses were bilateral, only left (side of slipping foot) shoulder biomechanics, specifically moment generation rates, spherical elevation angle, and abduction angle were positively correlated with slip severity. Left shoulder responses were triggered later than left hip and knee responses. Delayed shoulder moment onsets, slower abduction moment generation rate, and reduced range of motion were found in older adults compared to their younger counterparts. Aim 2 results indicated a weak but statistically significant positive relationship between the timing of the slip-initiated downward head acceleration and the onset of the left shoulder flexion/extension moment (true only when slip severity was controlled in the analysis). In Aim 3, increased left shoulder flexion generation rate correlated with decreased COM perturbation.In conclusion, evidence presented in this study implies (1) arm responses play a role in balance recovery, (2) a legs-to-arms response sequence appears to drive the reaction to a slip, although the potential implication of the vestibular system cannot be ruled out, (3) age-related effects on arm responses may aggravate the risk of slips and falls in older adults.
Wearable Textile Antenna： Fabrics Investigation

There is a development and an increasing interest in wearable antennas and electronics in civil, medical, sport wear and military domains. In this paper, our study focuses on the investigation of using different fabrics suitable for wearable application. The substrate of the patch antenna is made of three different very low cost textile materials. Radiating element and ground plane are made of copper tape. The three antennas operate at 6 GHz. measured results are compared with simulations and good agreement was observed.
Nonlinear Dynamics of Deployable and Maneuverable Space Structures

Abstract : The research goals of this URI efforts are: (1) to study the effects of nonlinearities on the dynamics of deployable and maneuverable structures, including the possibility of chaotic or transient dynamics, (2) to design experiments to study slewing transients of flexible structures both to test the analytical models and to explore for possible unmodelled dynamic effects, (3) to study the motion of unfolding of deployable structures, and (4) to advance computational capability for the simulation of dynamic controlled deployment and maneuver of large flexible structures. The accomplishments include: (1) developed a soliton deployment strategy for folded panel space structures, (2) showed spatially complex and chaotic solutions of a twisted elastica, (3) established evidence for transition from soliton to chaotic transient dynamics, (4) developed a robust cable controlled flexible robot arm structure, (5) completed the structural modelling, attribute assignment and visualization capabilities of an interactive graphic 3-D system for dynamic and static structural analysis, and 6) completed work on coarse-grained parallel processing for nonlinear structural dynamics by developing new explicit and implicit analysis and automatic domain partitioning algorithm for load balancing among processors. Nonlinear structural dynamics, Space structures, Structural computational mechanics, Structural modeling
Hybrid convergent ablation versus endocardial catheter ablation for atrial fibrillation: A systematic review and meta‐analysis

Endocardial catheter ablation (ECA) for atrial fibrillation (AF) has limited efficacy. Hybrid convergent procedure (HCP) with both epicardial and endocardial ablation is a novel strategy for AF treatment. In this meta‐analysis, we aimed to evaluate the efficacy and safety of HCP in AF ablation.
Intra-Inter View Interaction Network for Light Field Image Super-Resolution

Light field (LF) cameras, which can record real-word scenes from multiple viewpoints in a single shot, are widely used in 3D reconstruction, re-focusing, and virtual reality etc. However, the inherent trade-off between spatial resolution and angular resolution of LF images hinders their applications for scenarios requiring high resolutions. In this paper, we propose a novel intra-inter view interaction network for LF image super-resolution, termed as LF-IINet, to exploit the correlations among all views and simultaneously preserve the parallax structure of LF views. The proposed LF-IINet consists of two parallel branches. Specifically, the top branch extracts global inter-view information, and the bottom branch first independently maps each view to deep representations and then models the correlations among all intra-view features via proposed multi-view context block (MCB). The two branches interact with each other by proposed inter-assist-intra feature updating module (IntraFUM, where the intra feature are updated with the assistance of the inter feature) and intra-assist-inter feature updating module (InterFUM, where the inter feature are updated with the assistance of the intra feature). In this way, our LF-IINet incorporates rich angular and spatial information for LF image super-resolution. Extensive comparison with state-of-the-art methods demonstrates that our method achieves superior performance visually and quantitatively. Furthermore, quantitative results also show that our method is effective for LF images with either small or large disparities. Our code is shared in https://github.com/GaoshengLiu/LF-IINet.
A Single-MOSFET Analog High Resolution-Targeted (SMART) Multiplier for Machine Learning Classification

Mixed-signal machine-learning classification has recently been demonstrated as an efficient alternative for classification with power expensive digital circuits. In this paper, a single-MOSFET analog multiplier is proposed for classifying high-dimensional input data into multi-class output space with less power and higher accuracy than state-of-the-art mixed-signal linear classifiers. A high-resolution (i.e., multi-bit) multiplication is facilitated within a single-MOSFET by feeding the features and feature weights into, respectively, the body and gate inputs. High-resolution classifier that considers the decisions of the individual predictors is designed at 180nm technology node and operates at 100MHz in near/subthreshold region. To evaluate the performance of the classifier, a reduced MNIST dataset is generated by downsampling the MNIST digit images from 784 features to 48 features. The system is simulated across a wide range of PVT variations, exhibiting average accuracy of 92% (2% improvement over state-of-the-art), energy consumption of 67.3pJ per classification (over 8 times lower than state-of-the-art classifiers), area of 27,570 $\mu \text {m}^{2}$ per binary classifier, and a stable response under PVT variations. Finally, to provide ground for future work on ultra-low-power deep and convolutional networks, scalability and robustness of the proposed multiplier is evaluated with a convolutional neural network on CIFAR-10. Similar classification accuracy with digital and SMART hardware has been observed. All the code and simulation files are available at an online public GitHub repository, https://github.com/faridken/SMART-Multiplier-for-ML.
Iowa women as tourists and consumers of souvenirs

This study shows how Iowa women tourists differ in their travel behavior, souvenir purchases, and the status of textiles and clothing in the souvenir market. Interviews characterized 42 women, half each in the early-adulthood (EA) and middle-adulthood (MA) eras of Levinson (1978. 1986). Seven were unmarried. Reported annual family incomes were <$10,000 to >$75,000. Trip-planning styles and souvenir-purchase styles classify the informants into five groups. Group I. Low-involvement Travelers, were in EA, made unplanned souvenir purchases, and were minimal trip planners. These nine formed the least well-traveled group of any. and made the lowest average number of purchases of personal souvenirs, but the second highest of gifts. Textiles constituted 35% of their purchases. Group II. Laid-back Travelers, were seven minimal trip planners who made either planned or both planned and unplanned souvenir purchases. Selectiveness is apparent in the low average numbers of purchases in all categories despite high incomes. Textiles were 29% of their purchases. Group III, Centrist Travelers, made pre-planned trips but unplanned purchases. These five purchased the fewest gifts and few personal souvenirs, perhaps due to the unplanned nature of purchases and a low emphasis on family. Textiles constituted 30% of their purchases. Group IV. Goal-attainment Travelers, pre-planned their trips and made both planned and unplanned purchases. The average numbers of purchases of personal souvenirs by these eight were second highest of the
Tumor Volume Reduction Rate to Induction Chemotherapy is a Prognostic Factor for Locally Advanced Head and Neck Squamous Cell Carcinoma: A Retrospective Cohort Study

Introduction: Aim of this retrospective cohort study is to evaluate the prognostic value of tumor volume reduction rate status post-induction chemotherapy in locally advanced head and neck squamous cell carcinoma. Methods: Patients newly diagnosed from year 2007 to 2016 at a single center were included in this retrospective study. All patients had received induction Taxotere, Platinum, Fluorouracil followed by daily definitive intensity-modulated radiotherapy for 70 Gy in 35 fractions concurrent with or without cisplatin-based chemotherapy. Tumor volume reduction rate was measured and calculated by contrast-enhanced computed tomography images at diagnosis, and after at least 1 cycle of induction chemotherapy, and analyzed though a univariate and multivariate Cox regression model. Results: Ninety patients of the primary cancer sites at hypopharynx (31/90, 34.4%), oropharynx (29/90, 32.2%), oral cavity (19/90, 21.1%), and larynx (11/90, 12.2%) were included in this study, with a median follow-up time interval of 3.9 years. In multivariate Cox regression analysis, the tumor volume reduction rate of the primary tumor (TVRR-T) was also an independently significant prognostic factor for disease-free survival (DFS) (hazard ratio 0.77, 95% confidence interval 0.62-0.97; P-value = .02). Other factors including patient's age at diagnosis, the primary cancer site, and RECIST (Response Evaluation Criteria in Solid Tumors), were not significantly related. At a cutoff value using 50% in Kaplan–Meier survival analysis, the DFS was higher with TVRR-T ≥ 50% group (log-rank test, P = .024), and a trend of improved overall survival. (log-rank test, P = .069). Conclusion: TVRR-T is a probable prognostic factor for DFS. With a cut-off point of 50%, TVRR-T may indicate better DFS.
Polyphenols Targeting MAPK Mediated Oxidative Stress and Inflammation in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disorder, predominantly symmetric, which causes joint inflammation, cartilage degeneration and bone erosion, resulting in deformity and the loss of physical function. Although the management of RA has steadily improved, the pathophysiological mechanism is incompletely elucidated, and therapeutic options are still limited. Due to shortcomings in the efficacy or safety profiles of conventional RA therapies, therapeutic alternatives have been considered. Therefore, natural extracts containing polyphenolic compounds can become promising adjuvant agents for RA global management, due to their antioxidant, anti-inflammatory and apoptotic properties. Polyphenols can regulate intracellular signaling pathways in RA and can generate different immune responses through some key factors (i.e., MAPK, interleukins (ILs 1 and 6), tumor necrosis factor (TNF), nuclear factor light k chain promoter of activated receptor (NF-κB), and c-Jun N-terminal kinases (JNK)). The critical function of the Toll like-receptor (TLR)-dependent mitogen-activating protein kinase (MAPK) signaling pathway in mediating the pathogenic characteristics of RA has been briefly discussed. Oxidative stress can trigger a change in transcription factors, which leads to the different expression of some genes involved in the inflammatory process. This review aims to provide a comprehensive perspective on the efficacy of polyphenols in mitigating RA by inhibiting signaling pathways, suggesting future research perspectives in order to validate their use.
The Development of TLM Models for Nonlinear Optics

1 Abstract – A review of techniques for modelling dispersive and nonlinear materials using the TLM method is presented. The materials are those commonly used in optics, although the methodology is directly transferable to microwave and lower frequencies. It is shown that use of the Duffing model for devices exhibiting both nonlinear and dispersive nature provides more physically meaningful results than those of a simple Kerr model.
Overexpression of ZNT1 and NRAMP4 from the Ni Hyperaccumulator Noccaea caerulescens Population Monte Prinzera in Arabidopsis thaliana Perturbs Fe, Mn, and Ni Accumulation

Metalliferous soils are characterized by a high content of metal compounds that can hamper plant growth. The pseudometallophyte Noccaea caerulescens is able to grow on metalliferous substrates by implementing both tolerance and accumulation of usually toxic metal ions. Expression of particular transmembrane transporter proteins (e.g., members of the ZIP and NRAMP families) leads to metal tolerance and accumulation, and its comparison between hyperaccumulator N. caerulescens with non-accumulator relatives Arabidopsis thaliana and Thlaspi arvense has deepened our knowledge on mechanisms adopted by plants to survive in metalliferous soils. In this work, two transporters, ZNT1 and NRAMP4, expressed in a serpentinic population of N. caerulescens identified on the Monte Prinzera (Italy) are considered, and their expression has been induced in yeast and in A. thaliana. In the latter, single transgenic lines were crossed to test the effect of the combined over-expression of the two transporters. An enhanced iron and manganese translocation towards the shoot was induced by overexpression of NcZNT1. The combined overexpression of NcZNT1 and NcNRAMP4 did perturb the metal accumulation in plants.
On the benefits of virtual network topology control based on attractor selection model in changing environments (フォトニックネットワーク)

Virtual Network Topology (VNT) is one efficient way to transfer IP packets over wavelength-routed optical networks. In recent years various new services have emerged, and IP traffic has been highly fluctuated. Therefore, adaptability against changes of traffic is one of the most important characteristics to accommodate the IP traffic efficiently. To achieve the adaptability, we have proposed a VNT control method using an attractor selection model. In this paper, we investigate the effect of number of transmitters/receivers that restrict the number of lightpaths between node pairs of our method via computer simulations. Simulation results indicate that to achieve an adaptive VNT controls to the changes of network environments, enough number of transmitters/receivers is crucial. With this case, our VNT control based on attractor selection achieves good adaptability to the traffic change and lower control durations.