Miracle-dz/UniFAR-FTUs huggingface dataset:
VB-MAPP: Verbal Behavior Milestones Assessment and Placement Program, Protocol

VB-MAPP proporciona a educadores y padres un medio eficaz para evaluar el aprendizaje, el lenguaje y las habilidades sociales de niños y niñas con autismo u otras necesidades educativas especiales. El VB-MAPP tiene como fundamentos el análisis del lenguaje de B. F. Skinner, los principios del análisis de conducta y los hitos del desarrollo. El VB-MAPP ofrece un enfoque de evaluación exhaustivo y bien fundamentado que puede ayudar a identificar las barreras que impiden el aprendizaje y el desarrollo lenguaje, ayudando a orientar el desarrollo de planes educativos individualizados. VB-MAPP está compuesto de la presente guía y del protocolo individual. La presente guía proporciona para cada hito una explicación detallada, sus criterios de puntuación y multitud de ejemplos. La guía describe las posibles barreras al aprendizaje y la evaluación de la transición, así como instrucciones generales de puntuación y consejos para el evaluador. El contenido del protocolo del VB-MAPP se resume a continuación: • Evaluación de los hitos del lenguaje. Se centra en 170 hitos que constituyen la base del lenguaje, el aprendizaje y el desarrollo social. Los hitos están secuenciados en tres niveles de desarrollo (0-18 meses, 18-30 meses y 30-48 meses) Se incluyen criterios de medida objetivos para evaluar los resultados de la intervención. Incluye una evaluación específica de la conducta ecoica creada por la Dra. Barbara Esch, analista de conducta y terapeuta del lenguaje. La escala ha sido adaptada a las características propias del español para esta edición. Las secciones del VB-MAPP tienen colores diferentes a fin de facilitar su uso. • Evaluación de barreras. Cubre 24 barreras que pueden impedir la adquisición de nuevas habilidades. • Evaluación de la transición. Una evaluación abreviada de 18 áreas que sirve de guía para la planificación de las necesidades educativas del estudiante. • Análisis de tareas y habilidades de apoyo. Una lista de comprobación de aproximadamente 750 habilidades que apoyan los hitos del lenguaje y que pueden integrarse con el currículum de enseñanza.
Effect of Helicobacter pylori Eradication on Epigenetic Changes in Gastric Cancer-related Genes

It is known that gastric carcinogenesis results from the progressive changes from chronic gastritis to gastric atrophy, intestinal metaplasia, dysplasia, and invasive carcinoma. Several genetic and epigenetic alterations are involved in this process, and Helicobacter pylori (H. pylori) infection is believed to induce the initiation and progression of these steps. From an epigenetic point of view, H. pylori induces hypermethylation of genes involved in the development of gastric cancer and regulates the expression of various microRNAs (miRNAs). These H. pylori-related epigenetic changes are accumulated not only at the site of neoplasm but also in the adjacent non-cancerous gastric mucosa. Thereby, a state vulnerable to gastric cancer known as an epigenetic field defect is formed. H. pylori eradication can have an effective chemopreventive effect in gastric carcinogenesis. However, the molecular biological changes that occur in the stomach environment during H. pylori eradication have not yet been established. Several studies have reported that H. pylori eradication can restore infection-related changes, especially epigenetic alterations in gastric cancer-related genes, but some studies have shown otherwise. Simply put, it appears that the recovery of methylated gastric cancer-related genes and miRNAs during H. pylori eradication may vary among genes and may also differ depending on the histological subtype of the gastric mucosa. In this review, we will discuss the potential mechanism of gastric cancer prevention by H. pylori eradication, mainly from an epigenetic perspective.
Random telegraph signal and 1/f noise in forward-biased single-walled carbon nanotube film-silicon Schottky junctions

The electronic noise of single-walled carbon nanotube (CNT) film-Silicon Schottky junctions under forward bias is experimentally characterized. The superposition of a stable 1/f noise and a temporally unstable Lorentzian noise is observed, along with a random telegraph signal (RTS) in the time domain. The data analysis shows that the Lorentzian noise results from the RTS current fluctuations. The data agree well with theoretical descriptions of noise in Schottky junctions due to carrier trapping and detrapping at interface states. Understanding the noise properties of CNT film-Si junctions is important for the integration of CNT film electrodes into silicon-based devices.
Temporal Lobe Epilepsy in Multiple Sclerosis Resembling Autoimmune Limbic Encephalitis

Background: Temporal lobe seizures are typical symptoms in patients with Autoimmune Limbic Encephalitis (ALE), but also occur in the context of Multiple Sclerosis (MS). We here report a series of four patients with Temporal Lobe Epilepsy (TLE) and MS with features of ALE, focusing on clinical, MRI, EEG and serological findings. Arch Clin Med Case Rep 2021; 5 (6): 941-949 DOI: 10.26502/acmcr.96550438 Archives of Clinical and Medical Case Reports 942 Case series: Four patients diagnosed with relapsingremitting (RR) or primary progressive (PP) forms of MS according to the amended McDonald criteria from 2017 and TLE with additional features of ALE (according the Graus criteria from 2016) were retrospectively identified based on medical records from five German tertiary epilepsy centers. All patients (female) suffered from additional limbic symptoms including memory disturbances and depression. All patients had additional signs of bilateral temporomesial affection on MRI and bilateral temporal slowing and epileptiform activity on EEG. Three patients had CSFspecific oligoclonal bands. In two patients TLE with additional limbic symptoms preceded MS, in one patient MS preceded TLE, and in one patient TLE and MS occurred simultaneously. In all cases, serum and CSF samples were negative for well-characterized neuronal antibodies. Conclusions: Our case series showed that TLE and MS symptoms may resemble the symptoms of ALE. Diagnosing of overlapping MS and ALE could not be made definitively because neither clinical symptoms nor temporomesial MRI findings could help clearly to distinguish between MS and antibody-negative ALE.
A Revisit to YACRIT: Yet Another Channel Router with Interchangeable Terminals

This paper presents new algorithms for routing two rows of interchangeable terminals across a two-layer channel. In this case, the number of horizontal tracks required for routing is reduced significantly by simply interchanging the terminals in each cell. It has been found that on the average approximately 40% channel area or often more is saved just by interchanging the terminals. In practice, actually, on the design table of forming the final net list from a net list just given in the form of rows of terminals necessary for routing, or partially constructed channel instances are given for rearranging their terminals so that area required for routing is minimized. The number of horizontal tracks per net is assumed to be one, i.e., no-dogleg routing is performed, and subsequently with the help of each of the algorithms developed in this paper at least one feasible solution is always computed without doglegging. A generalized study is also encountered considering existence of more than two cells on a side of the given channel where cells are fixed at their relative positions though the terminals within a cell are interchangeable; intercell interchanges of terminals are not allowed.
Selection and Fusion of Indicators for Network Security Situational Awareness

Network security situational awareness process collects security data from system log and security tools, extracts values of situational indicators and fuses these indicators values into security situation value. The security situational value reflects the all-side security situation of cyberspace. The selection and fusion of indicators become critical to precision of situation value. In the paper, an approach will be introduced to select indicators based on a hierarchical framework of network security situational awareness. These indicators will be fused into situation value depended on formulas that are deduced in accordance with the hierarchical framework.
Zero-voltage-switching technique in high-frequency off-line converters

Zero-voltage switching (ZVS) is implemented using a half-bridge (HB) topology for high-frequency offline applications. Two ZVS techniques are discussed: one is a quasiresonant technique (QRC) the other a multiresonant technique (MRC). A breadboarded HB ZVS-QRC is presented which operates from a 300+or-50 V input with maximum output power of 75 W (5 V, 15 A) and an efficiency of 83.5% at low line and full load and 79.2% at high line and full load. In ZVS-MRCs, all semiconductor devices are operated with no abrupt changes of the voltage across the devices. The technique permits utilization of junction capacitances of all semiconductor devices and the transformer leakage inductance to form a multiple-resonant-tank network to implement zero-voltage switching for all semiconductor devices. Employing this technique, a HB ZVS-MRC is breadboarded with the same specifications as the HB ZVS-QRC. The efficiency of the HB ZVS-MRC is slightly lower than that of the HB ZVS-QRC, 81.7% at full load and low line and 78.5% at full load and high line. <<ETX>>
A solar battery charger with improved energy utilization

It is desirable to extract maximum power from solar cells under various sunlight insolation conditions, for battery charging applications. An economical solar battery charger and its control principle are proposed and implemented by the authors. The operating principles, effects of circuit parameters and comparative test results are presented in the paper. The test results show that the proposed charger improves the energy utilization at both low and high insolation conditions. <<ETX>>
Microcontroller-Based Variable Speed Drive for Three-Phase Induction Motor in Cooling Applications

This paper presents an electronic VSD (variable speed drive) for three-phase IM (induction motor) using a microcontroller. The VSD is designed for cooling applications where the IM is coupled to a cooling fan. The drive receives temperature feedback from objects to be cooled and output a corresponding frequency to the IM. A prototype of the VSD is constructed to control a 175 W, four pole, squirrel cage three-phase IM. The heart of the control circuit is a low-cost microchip's PIC16F777 microcontroller which is programmed using C language to generate variable frequency SPWM (sinusoidal pulse width modulation) switching signals. These switching signals are fed to an IGBT inverter. The VSD constructed can be switched between two modes of speed control: automatic temperature-controlled mode and manual user-controlled mode. Cost savings using the prototype are demonstrated.
Age and Not the Preferred Limb Influences the Kinematic Structure of Pointing Movements

In goal-directed movements, effective open-loop control reduces the need for feedback-based corrective submovements. The purpose of this study was to determine the influence of hand preference and aging on submovements during single- and two-joint pointing movements. A total of 12 young and 12 older right-handed participants performed pointing movements that involved either elbow extension or a combination of elbow extension and horizontal shoulder flexion with their right and left arms to a target. Kinematics were used to separate the movements into their primary and secondary submovements. The older adults exhibited slower movements, used secondary submovements more often, and produced relatively shorter primary submovements. However, there were no interlimb differences for either age group or for the single- and two-joint movements. These findings indicate that open-loop control is similar between arms but compromised in older compared to younger adults.
Intersection detection and recognition for autonomous urban driving using a virtual cylindrical scanner

In this study, the authors propose an effective real-time approach for intersection detection and recognition during autonomous driving in an unknown urban environment. The authors approach use point cloud data acquired by a three-dimensional laser scanner mounted on the vehicle. Intersection detection and recognition are formulated as a classification problem whereby roads are classified as segments or intersections and intersections are subclassified as T-shaped or +-shaped. They first construct a novel model called a virtual cylindrical scanner for efficient feature-level representation of the point cloud data. Then they use support vector machine classifiers to resolve the classification problem according to the features extracted. A series of experiments on real-world data sets and in a simulation environment demonstrate the effectiveness and robustness of the authors approach, even in highly dynamic urban environment. They also performed simulation experiments to investigate effects of several critical factors on their proposed approach, such as other vehicles on the road and the advance detection distance.
Filament-Based Fabrication and Performance Analysis of Fiber Bragg Grating Sensors Using Ultrashort Pulse Laser

The method of ultrashort pulse filamentation induced refractive index modification is employed to inscribe fiber Bragg grating (FBG) in single-mode optical fiber (SMF). Line-by-line index inscription technique is used to write refractive index modulation in the core of SMF. The proposed pulse filamentation based index modification enables controlled and flexible writing of FBGs in optical fibers. Performance analysis of the fabricated FBG has been carried out for temperature, contact force, pressure, and axial strain sensing. The in-fiber FBG exhibits sensing performance very similar to FBGs commercially available to date. Then, the written FBG is engineered to demonstrate highly sensitive contact force sensor.
Metabolomic analysis of plasma and intramuscular adipose tissue between Wagyu and Holstein cattle

In this experiment, we studied the effects of breed differences in intramuscular adipogenic capacity on the metabolomic profiles of plasma and intramuscular adipose tissue between Wagyu (high intramuscular adipogenic capacity) and Holstein (low intramuscular adipogenic capacity) using capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS). We showed that the intramuscular fat content, intramuscular adipocyte size and the expression of adipogenic transcription factors (C/EBPβ and C/EBPα) of Wagyu were significantly higher than those of Holstein. Metabolites detected at significantly higher levels in Wagyu plasma were related to the tricarboxylic acid cycle, lipid synthesis, fatty acid metabolism, diabetes, and glucose homeostasis. In contrast, metabolites detected at significantly higher levels in Holstein plasma were related to choline metabolism, the ethanolamine pathway, glutathione homeostasis, nucleic acid metabolism, and amino acid metabolism. Metabolites detected at significantly higher levels in Holstein intramuscular adipose tissue were related to nucleic acid metabolism, amino acid metabolism, amino sugar metabolism, beta oxidation, and the ethanolamine pathway. There were no metabolites significantly higher levels in Wagyu intramuscular adipose tissue. These results indicate candidate biomarkers of breed differences in intramuscular adipogenic capacity between Wagyu and Holstein.
Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled Receptor D Induces Release of the Inflammatory Cytokine IL-6 and Is Dependent on NF-κB Signaling

G protein-coupled receptors (GPCRs) have emerged as key players in regulating (patho)physiological processes, including inflammation. Members of the Mas-related G protein coupled receptors (MRGPRs), a subfamily of GPCRs, are largely expressed by sensory neurons and known to modulate itch and pain. Several members of MRGPRs are also expressed in mast cells, macrophages, and in cardiovascular tissue, linking them to pseudo-allergic drug reactions and suggesting a pivotal role in the cardiovascular system. However, involvement of the human Mas-related G-protein coupled receptor D (MRGPRD) in the regulation of the inflammatory mediator interleukin 6 (IL-6) has not been demonstrated to date. By stimulating human MRGPRD-expressing HeLa cells with the agonist β-alanine, we observed a release of IL-6. β-alanine-induced signaling through MRGPRD was investigated further by probing downstream signaling effectors along the Gαq/Phospholipase C (PLC) pathway, which results in an IkB kinases (IKK)-mediated canonical activation of nuclear factor kappa-B (NF-κB) and stimulation of IL-6 release. This IL-6 release could be blocked by a Gαq inhibitor (YM-254890), an IKK complex inhibitor (IKK-16), and partly by a PLC inhibitor (U-73122). Additionally, we investigated the constitutive (ligand-independent) and basal activity of MRGPRD and concluded that the observed basal activity of MRGPRD is dependent on the presence of fetal bovine serum (FBS) in the culture medium. Consequently, the dynamic range for IL-6 detection as an assay for β-alanine-mediated activation of MRGPRD is substantially increased by culturing the cells in FBS free medium before treatment. Overall, the observation that MRGPRD mediates the release of IL-6 in an in vitro system, hints at a role as an inflammatory mediator and supports the notion that IL-6 can be used as a marker for MRGPRD activation in an in vitro drug screening assay.
Multithreshold logic circuits implemented with operational amplifiers

ABSTRACT The paper presents a procedure for the synthesis or multithreshold circuits with up to four thresholds. The circuit has three operational amplifiers as its kernel. Given the weight-threshold vector of the boolean function which has to be obtained, the values of the different elements of the circuit are easily obtained. Noise immunity has been computed and has an acceptable value. One example of synthesis is included.
Recovery from Liver Failure and Fibrosis in a Rat Portacaval Anastomosis Model after Neurointermediate Pituitary Lobectomy

Liver diseases, including cirrhosis, viral hepatitis, and hepatocellular carcinoma, account for approximately two million annual deaths worldwide. They place a huge burden on the global healthcare systems, compelling researchers to find effective treatment for liver fibrosis-cirrhosis. Portacaval anastomosis (PCA) is a model of liver damage and fibrosis. Arginine vasopressin (AVP) has been implicated as a proinflammatory-profibrotic hormone. In rats, neurointermediate pituitary lobectomy (NIL) induces a permanent drop (80%) in AVP serum levels. We hypothesized that AVP deficiency (NIL-induced) may decrease liver damage and fibrosis in a rat PCA model. Male Wistar rats were divided into intact control (IC), NIL, PCA, and PCA+NIL groups. Liver function tests, liver gene relative expressions (IL-1, IL-10, TGF-β, COLL-I, MMP-9, and MMP-13), and histopathological assessments were performed. In comparison with those in the IC and PCA groups, bilirubin, protein serum, and liver glycogen levels were restored in the PCA+NIL group. NIL in the PCA animals also decreased the gene expression levels of IL-1 and COLL-I, while increasing those of IL-10, TGF-β, and MMP-13. Histopathology of this group also showed significantly decreased signs of liver damage with lower extent of collagen deposition and fibrosis. Low AVP serum levels were not enough to fully activate the AVP receptors resulting in the decreased activation of cell signaling pathways associated with proinflammatory-profibrotic responses, while activating cell molecular signaling pathways associated with an anti-inflammatory-fibrotic state. Thus, partial reversion of liver damage and fibrosis was observed. The study supports the crucial role of AVP in the inflammatory-fibrotic processes and maintenance of immune competence. The success of the AVP deficiency strategy suggests that blocking AVP receptors may be therapeutically useful to treat inflammatory-fibrotic liver diseases.
Effectivity of Health Education with Telenursing on the Self-care Ability of Coronary Artery Disease Patients: A Systematic Review

BACKGROUND: Coronary artery disease (CAD) develops chronically and progressively, causes recurrence and premature death, so a good knowledge of changes in self-care behavior by patients is needed. Telenursing can be a medium for health education to allow patients to receive information and for nurses to follow up on health conditions without being obstructed by distance, place, time, and carried out sustainably. So far, telenursing has not been reviewed as a recent intervention to deliver education to CAD patients. AIM: This systematic review aimed to determine the effectiveness of health education interventions with telenursing on the self-care of CAD patients based on the implementation media. METHODS: Systematic reviews were conducted based on items found in CINAHL EBSCO, PubMed, ScienceDirect, and Google Scholar from 2008 to 2019. The combination of keywords used Indonesian and English language. All articles were assessed using the Joanna Briggs Institute critical appraisal tool for randomized controlled trial (RCT) and quasi-experiment. After that, the study found was synthesized narratively. RESULTS: A total of 11.319 titles were identified, and seven studies met inclusion criteria with 3313 participants. Six studies were RCT studies, and one was a quasi-experimental study. The results of the narrative synthesis conducted on seven articles showed that health education by telenursing was effective in improving self-care ability, such as maintaining blood pressure, body mass index, hemoglobin A1c levels, fasting blood glucose, and low-density lipoprotein within normal limits. In addition, there was also an increase in physical activity, dietary compliance (consumption of fruits, vegetables and fish), control of salt intake, smoking, and alcohol cessation. The media used were phone calls and text messages. CONCLUSION: This review provides evidence that health education interventions effectively improve the self-care abilities of CAD patients with the media used are text messages and telephone calls.