Miracle-dz/UniFAR-FTUs huggingface dataset:
Letters to the editor Analysis of BCL-10 gene mutations Weekly paclitaxel plus Herceptin in metastatic breast cancer patients who relapse

The BCL-10 gene, cloned from the t(l;14)(p22;q32) chromosomal translocation associated with extranodal marginal zone B-cell lymphoma, has been reported to be mutated in human tumours of different histology [1, 2]. The gene codes for two alternative transcripts of 2.8 Kb and 1.3 Kb, which are expressed at low levels in all normal tissues and act as proapoptotic factors [2]. BCL-10 mutant alleles have been reported to have transforming activity in cell culture [1]. Wild type protein exhibits an amino-terminal caspase recruitment domain (CARD) which mediates the dimerization of BCL-10 proteins, determining the binding and cleavage of the zymogen pro-caspase-9, and a carboxy terminal region, rich in serine and threonine residues, whose function is not known [3]. BCL-10 locus at chromosome Ip22 has been reported to be deleted in ovarian cancer [4-6]. In the hypothesis that BCL-10 might act as a tumour suppressor gene in ovarian cancer, we performed mutational analysis of its full coding region, comprising exon-intron junctions, in a panel of eight ovarian cancer cell lines.
High-throughput identification of chrysanthemum gene function and expression: An overview and an effective proposition

Since whole-genome duplication (WGD) of diploid Chrysanthemum nankingense and de novo assembly whole-genome of C. seticuspe have been obtained, they have afforded to perceive the diversity evolution and gene discovery in the improved investigation of chrysanthemum breeding. The robust tools of high-throughput identification and analysis of gene function and expression produce their vast importance in chrysanthemum genomics. However, the gigantic genome size and heterozygosity are also mentioned as the major obstacles preventing the chrysanthemum breeding practices and functional genomics analysis. Nonetheless, some of technological contemporaries provide scientific efficient and promising solutions to diminish the drawbacks and investigate the high proficient methods for generous phenotyping data obtaining and system progress in future perspectives. This review provides valuable strategies for a broad overview about the high-throughput identification, and molecular analysis of gene function and expression in chrysanthemum. We also contribute the efficient proposition about specific protocols for considering chrysanthemum genes. In further perspective, the proper high-throughput identification will continue to advance rapidly and advertise the next generation in chrysanthemum breeding.
Web Service Selection Based on Integrated QoS Assesment

—Currently, web services are the preferred technology for implementation of distributed applications that follow a Service-Oriented Architecture. The promise of reduced cost and time for enabling a large range of company-wide business processes shifts the research focus towards reasoning about web service selection. This paper proposes an approach facilitating clients to select a web service among several ones with the same functionality based on their quality of service (QoS) properties. It provides a mechanism for integrated QoS assessment of web services taking into account all measured QoS properties of the client’s interest. The method estimates the strength of the mutual dependency of the QoS properties using a data set analysis of QoS values accumulated during the web service invocation. The approach is summarized in a step-by-step assessment procedure and is proved through a real web service selection scenario.
Microstrip leaky wave strip antennas

During the late 1870's. a paper presented by H. Ermert at the European Microwave Conference stimulated instant controversy. The paper was devoted to the properties of higher modes on microstrip line, and one of its conclusions was that a "radiation" region exists close to the cutoff of those modes. Because the description of this region, made in that talk and in published papers [1,2], was incomplete and therefore unclear to many, confusion persisted and certaln practical consequences remained hidden. Also in this general perlod. a paper by W. Menzel [3] presented a new traveling-wave antenna on microstrip line fed in its first higher mode and operated near t~ the cutoff of that mode. Menzel proposed his structure as a competitor to a microstrip patch antenna, and he therefore made his antenna short in terms of wavelength. He also assumed that the propagation wavenumber of the flrst higher mode was real in the very region where Ermert said no such solutions exist; since his guided wave, with a real wavenumber, was f a s t in that frequency range, Menzel presumed that i t should radiate. His approximate analysis and his physical reasoning were therefore also incomplete, but his proposed antenna was valid and his measurements demonstrated reasonably successful performance. The present paper flrst explains that the "radiation" region of Ermert is directly related to leaky modes, and that such a representation for this region is both convergent and practical. It then shows that Menzel's antenna Ls in reality a leaky wave antenna that was made too short: an accurate analysis of it not only explatns quantitatively the performance features of the antenna, but also indicates how they can be improved. Numerical values are presented to show what performance characteristics can be expected when leaky wave antennas of this class are properly designed.
Disclosure and Cost of Equity Capital: An Analysis at the Market Level

This study examines whether disclosure reduces the market cost of capital. A stock’s implied cost of capital is defined as the expected return that equates its current price to the present value of its expected future free cash flows. We compute implied costs of capital for each firm and use their average as a measure of the market cost of capital. Using a sample of management forecasts issued between 1994 and 2010, we find that an increase in disclosure at the aggregate level results in a lower market cost of capital. This result is robust to alternative measures of disclosure and implied cost of capital, and controls for book-to-market, momentum, conditional volatility, and other determinants of cost of capital. Overall, our findings are consistent with disclosure increasing overall information precision, resulting in a decrease in the cost of capital at the market level.
A Family of Coupled-Inductor-Based Soft-Switching DC–DC Converter With Double Synchronous Rectification

In this paper, several new coupled-inductor-based soft-switching dc–dc converters are proposed. These converters are obtained by changing the coupled branch of several existing dc–dc converters. Meanwhile they have similar characteristics to these existing converters, and provide more choices for the practical application. Then by applying an existing efficiency improvement method, which is used in the buck-type soft-switching converter, to all abovementioned converters, several new converters with efficiency improvement characteristics are obtained. This efficiency improvement method utilizes the low conduction performance of the transistor to reduce the loss. In addition, this method has the same control complexity to original topologies, because the auxiliary transistor has the same control timing to one of main transistors. The characteristic of new converters and efficiency improvement method are presented by analyzing two new topologies (boost-type converters). Finally simulation and experimental results are given and analyzed by designing a prototype. Based on these results, soft-switching conditions and efficiency improvement capability are verified.
Self-Adaptive Digital Assistance Systems for Work 4.0

In the era of digital transformation, new technological foundations and possibilities for collaboration, production as well as organization open up many opportunities to work differently in the future. The digitization of workflows results in new forms of working which is denoted by the term Work 4.0. In the context of Work 4.0, digital assistance systems play an important role as they give users additional situation-specific information about a workflow or a product via displays, mobile devices such as tablets and smartphones, or data glasses. Furthermore, such digital assistance systems can be used to provide instructions and technical support in the working process as well as for training purposes. However, existing digital assistance systems are mostly created focusing on the"design for all"paradigm neglecting the situation-specific tasks, skills, preferences, or environments of an individual human worker. To overcome this issue, we present a monitoring and adaptation framework for supporting self-adaptive digital assistance systems for Work 4.0. Our framework supports context monitoring as well as UI adaptation for augmented (AR) and virtual reality (VR)-based digital assistance systems. The benefit of our framework is shown based on exemplary case studies from different domains, e.g. context-aware maintenance application in AR or warehouse management training in VR.
Regulation Interaction Contributing to IL-4 q C-Protein Kinase - Molecule-Associated Protein Signaling Lymphocytic Activation Biochemical and Genetic Evidence for a

Signaling lymphocytic activation molecule-associated protein (SAP), an adaptor molecule that recruits Fyn to the signaling lymphocytic activation molecule (SLAM) family of immunomodulatory receptors, is mutated in X-linked lymphoproliferative disease. CD4 + T cells from SAP-deﬁcient mice have defective TCR-induced and follicular Th cell IL-4 production and impaired T cell-mediated help for germinal center formation; however, the downstream intermediates contributing to these defects remain unclear. We previously found that SAP-deﬁcient CD4 + T cells exhibit decreased protein kinase C (PKC)- u recruitment upon TCR stimulation. We demonstrate in this paper using GST pulldowns and coimmunoprecipitation studies that SAP constitutively associates with PKC- u in T cells. SAP–PKC- u interactions required R78 of SAP, a residue previously implicated in Fyn recruitment, yet SAP’s interactions with PKC- u occurred independent of phosphotyrosine binding and Fyn. Overexpression of SAP in T cells increased and sustained PKC- u recruitment to the immune synapse and elevated IL-4 production in response to TCR plus SLAM-mediated stimulation. Moreover, PKC- u , like SAP, was required for SLAM-mediated increases in IL-4 production, and, conversely, membrane-targeted PKC- u mutants rescued IL-4 expression in SAP 2 / 2 CD4 + T cells, providing genetic evidence that PKC- u is a critical component of SLAM/SAP-mediated pathways that inﬂuence TCR-driven IL-4 production.
Coarticulatory Variability and Directionality in [ (cid:1) , (cid:2) , (cid:3) ]: an EPG study

Articulatory properties of the sibilants [ (cid:1) , (cid:2) ] and non-sibilant [ (cid:3) ] were studied for VCV syllables in Japanese, using the technique of electropalatography. We examined the relation between constriction width and location, and the nature of coarticulatory variability and directionality, specific to the two fricative categories. The results allow us to discuss the phonetic basis of the ‘precision’ in fricative articulations.
Ca V 1.2 and Ca V 1.3 voltage-gated L-type Ca 2+ channels in rat white fat 1 adipocytes.

L-type channel antagonists are of therapeutic benefit in the treatment of 26 hyperlipidaemia and insulin resistance. Our aim was to identify L-type 27 voltage gated Ca 2+ channels in white fat adipocytes, and determine if they 28 affect intracellular Ca 2+ , lipolysis and lipogenesis. We used a 29 multidisciplinary approach of molecular biology, confocal microscopy, Ca 2+ 30 imaging and metabolic assays, to explore this problem using adipocytes 31 isolated from adult rat epididymal fat pads. Ca V 1.2, Ca V 1.3 and Ca V 1.1 32 alpha 1 , beta and alpha 2 delta subunits were detected at the gene expression 33 level. The Ca V 1.2 and Ca V 1.3 alpha1 subunits were identified in the plasma 34 membrane at the protein level. Confocal microscopy with fluorescent 35 antibodies labelled Ca V 1.2 in the plasma membrane. Ca 2+ imaging revealed 36 that the intracellular Ca 2+ concentration, [Ca 2+ ] i , was reversibly decreased 37 by removal of extracellular Ca 2+ , an effect mimicked by verapamil, 38 nifedipine and Co 2+ , all blockers of L-type channels. Whereas the Ca 2+ 39 channel agonist The finding that the 40 magnitude of these effects correlated with basal [Ca 2+ ] i suggests that 41 adipocyte [Ca 2+ ] i is controlled by L-type Ca 2+ channels that are 42 constitutively active at the adipocyte depolarized membrane potential. 43 Pharmacological manipulation of L-type channel activity modulated both 44 basal and catecholamine-stimulated lipolysis but not insulin-induced 45 glucose uptake or lipogenesis. We conclude that white adipocytes have 46 constitutively active L-type Ca 2+ channels which explains sensitivity of 47 lipolysis to Ca 2+ channel modulators. Our data suggest Ca V 1.2 as a potential 48 novel therapeutic target in the treatment of obesity. 49
The Open Nursing Journal Morphine Use Did Not Eliminate the Effect of Pain on Complications After Acute Myocardial Infarction.

: Background: Patients with Acute Myocardial Infarction (AMI) are usually present complaining of severe chest pain. This pain results from an imbalance between oxygen supply and demand, leading to severe complications. Different guidelines recommend using Morphine as a drug of choice for treating this pain. Objective: This study aimed to check the effect of chest pain and Morphine use on complications rate after AMI. Methods: This was a prospective observational study with a consecutive sample of 300 patients with AMI. Data were collected by direct patients interview and medical records review in the emergency departments & Intensive Care Units (ICU). Any complication developed within the hospital stay and after AMI was recorded. All correlated variables were analyzed using the binary logistic regression model. Results: The sample than 13%, 7%, 63%, 25%, Morphine the of of chest pain increased the occurrence of complications. Morphine administration did not have any protective effect against the development of these complications. Thus, it is recommended to update different policies and guidelines to use other types of chest pain relief methods, e.g . , treating the underlying cause of chest pain and addressing the imbalance between oxygen supply and demand.
Blockade Therapies in Patients with Metastatic Urothelial Carcinoma

Deniz Tural (  deniztural@gmail.com ) Istanbul Bakirkoy Dr Sadi Konuk Egitim ve Arastirma Hastanesi https://orcid.org/0000-0003-21446469 Fatih Selçukbiricik Koç Üniversitesi: Koc Universitesi Ömer Fatih Ölmez Istanbul Medipol University: Istanbul Medipol Universitesi Ahmet Taner Sümbül Başkent Üniversitesi: Baskent Universitesi Mustafa Erman Hacettepe University: Hacettepe Universitesi Hasan Şenol Coşkun Akdeniz Üniversitesi: Akdeniz Universitesi Mehmet Artaç Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi: Necmettin Erbakan Universitesi Meram Tip Fakultesi Saadettin Kılıçkap İstinye Üniversitesi: Istinye Universitesi
by Razin A. Shaikh, Sara Sabrina Zemljic,

In this report we present a new model of concepts, based on the framework of variational autoencoders, which is designed to have attractive properties such as factored conceptual domains, and at the same time be learnable from data. The model is inspired by, and closely related to, the β -VAE model of concepts, but is designed to be more closely connected with language, so that the names of concepts form part of the graphical model. We provide evidence that our model—which we call the Conceptual VAE —is able to learn interpretable conceptual representations from simple images of coloured shapes together with the corresponding concept labels. We also show how the model can be used as a concept classiﬁer, and how it can be adapted to learn from fewer labels per instance. Finally, we formally relate our model to G¨ardenfors’ theory of conceptual spaces, showing how the Gaussians we use to represent concepts can be formalised in terms of “fuzzy concepts” in such a space.
Towards Secure and Verifiable Computation of KNN Queries in Outsourced Environments

The popularity of cloud computing has increased significantly in the last few years due to scalability, cost efficiency, resiliency, and quality of service. Organizations are more interested in outsourcing the database and DBMS functionalities to the cloud owing to the tremendous growth of big data and on-demand access requirements. As the data is outsourced to untrusted parties, security has become a key consideration to achieve the confidentiality and integrity of data. Therefore, data owners must transform and encrypt the data before outsourcing. In this paper, we focus on a Secure and Verifiable Computation for k-Nearest Neighbor (SVC-kNN) problem. The existing verifiable computation approaches for the kNN problem delegate the verification task solely to a single semi-trusted party. We show that these approaches are unreliable in terms of security, as the verification server could be either dishonest or compromised. To address these issues, we propose a novel solution to the SVC-kNN problem that utilizes the random-splitting approach in conjunction with the homomorphic properties under a two-cloud model. Specifically, the clouds generate and send verification proofs to end-users, allowing them to verify the computation results efficiently. Our solution is highly efficient from the data owner and query issuers’ perspective as it significantly reduces the encryption cost and pre-processing time. Furthermore, we show the correctness of our solution using Proof by Induction methodology to prove the Euclidean Distance Verification. Finally, with a thorough analysis and the empirical results on a real data set, we demonstrate the efficiency and effectiveness of our protocol. College of Science and Mathematics Computer Science MONTCLAIR STATE UNIVERSITY Towards Secure and Verifiable Computation of KNN Queries in Outsourced Environments
Exactly azimuthal pixelizations of the sky

We investigate various pixelizations of the sky which allow for fast spherical transforms, for implementation in full sky CMB experiments such as Planck and MAP. We study the effect of varying pixel shape and area on the extraction of the CMB power spectrum. We argue for the benefits of having a truly azimuthal, or `igloo' pixelization. Such pixelizations are simple and allow for fast, exact simulations of pixelized skies. They also allow for precise correction to be made which accounts for the effects of pixel smoothing on extracted multipole moments.
Compensating noise and reverberation in far-field Multichannel Speaker Verification

—Speaker verification (SV) suffers from unsatisfactory performance in far-field scenarios due to environmental noise and the adverse impact of room reverberation. This paper investigates utilizing a multichannel pre-processing pipeline including a time-domain neural beamformer (FaSNet), multi-channel Wiener filter (MWF), and weighted prediction error (WPE). This approach is compared to the existing state-of-the-art approaches. We examine the importance of enrollment in pre-processing which has been largely overlooked in previous studies. Experimental evaluation shows that pre-processing can improve the SV performance as long as the enrollment files are processed similarly to the test data and that test and enrollment occur within similar SNR ranges. The integration of FaSNet, MWF, and WPE achieved improved performance compared to the existing state-of-the-art pre-processing approaches. We also show that our approach generalizes to unseen real recorded data while being trained on simulated data.
Contributed comment on Article by Hahn, Murray, and Carvalho

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Contributed comment on Article by Hahn, Murray, and Carvalho Daria Bystrova, Julyan Arbel, Thibaud Rahier
Central limit theorem for CβE pair dependent statistics in mesoscopic regime

We extend our results on the ﬂuctuation of the pair counting statistic of the Circular Beta Ensemble (cid:80) i (cid:54) = j f ( L N ( θ i − θ j )) for arbitrary β > 0 in the mesoscopic regime L N = O ( N 2 / 3 − (cid:15) ) . In addition, we obtain similar results for bipartite statistics.
Bone-mineral density: clinical signi ﬁ cance, methods of quanti ﬁ cation and forensic applications

: Bone-mineral density (BMD) is a measure of the inorganic mineral content in bone, and is one of the more informative assessments of bone quality in both clinical studies and forensic investigations. Several factors, such as age, sex, disease, genetics, and lifestyle, affect BMD measurements, and normative standards must be applied for speci ﬁ c groups and individuals. One of the most common disorders associated with low BMD is osteoporosis and increased fracture risk, due to a decrease in bone strength and an increase in bone fragility. Medical conditions like diabetes or hyperthyroidism and other parameters like peak bone mass and postmenopausal estrogen de ﬁ ciency also impact BMD. Single- and dual-energy photon absorptiometry, quantitative computet tomography, and magnetic resonance imaging are some of the technological modalities for BMD quanti ﬁ cation, and each presents distinct advantages and limitations, depending on the purpose of the analysis, the speci ﬁ c characteristics of the individual, the bone site under examination, and the equipment and trained personnel available. Recently, BMD values were applied to forensic medicine in a variety of scenarios ranging from age and sex estimation to the assessment of malnutrition and the use of ﬁ nite-element modelling. Despite technical and methodological inconsistencies reported in the literature on BMD readings, there is scope for expanding the use of this variable in forensic settings. postmenopausal bone loss at the distal forearm and hip that lasts throughout postmenopausal life, and a bone loss at the lumbar