Miracle-dz/UniFAR-FTUs huggingface dataset:
Degradation of Arable Soils in Central Yakutia: Negative Consequences of Global Warming for Yedoma Landscapes

Global warming, which is especially intensive (up to 0.08°C yr−1) in permafrost area of Central Yakutia, has dramatic consequences for scarce arable land resources in this region. In Yedoma landscapes, intense permafrost thawing on arable fields unprotected by forest vegetation transforms the surface microtopography with the formation of residual thermokarst mounds (byllars) of 6–10 m in diameter surrounded by a polygonal network of hollows of 0.3–1.5 m in depth above melting ice wedges. This process also takes place on former croplands abandoned in the recent decades because of socioeconomic reasons. It is accompanied by a significant transformation of the previously highly likely homogeneous soil cover composed of Cambic Turbic Cryosols (Sodic) into differentiated complexes of permafrost-affected Stagnic Cambisols or Calcic Solonetzes (Turbic) on the mounds and Calcic Stagnic Solonetzes (Turbic) in the microlows. Surface soil horizons on the mounds have a strongly to very strongly alkaline reaction (pH 8.5–9.5) and low (<2%) organic carbon content; a wavy line of effervescence is found at a depth of 15–30 cm. Soils in the microlows have a close to neutral reaction in the upper horizons (pH 6.2–7.5); higher organic carbon content (2–3%); more pronounced textural differentiation of the profile with the formation of typical natric Btn and, in some cases, overlying eluvial E horizons; deeper (50–60 cm) line of effervescence; and clear stagnic features in the lower part of the profile. In the case of shallow embedding by ice wedge, the lowermost part of the soil in the microlow is characterized by the low bulk density (1.04 g cm−3) because of the appearance of hollows after thawing of the ice-rich transient layer and melting of the top of ice wedges. This may be indicative of the further soil subsidence in the future and the appearance of initial thermokarst lakes (dyuedya) within the Yedoma terrain with its transformation into the alas type of landscape. Rapid thermokarst-driven development of microtopography followed by differentiation of the soil cover with increasing soil alkalinity on the microhighs and soil textural differentiation and overmoistening of deep layers in the microlows prevents the return of abandoned arable land to agriculture in Yedoma landscapes.
High-Intensity Interval Training for Heart Failure Patients With Preserved Ejection Fraction (HIT-HF)-Rational and Design of a Prospective, Randomized, Controlled Trial

Background: The pathophysiology of HF with preserved ejection fraction (HFpEF) has not yet been fully understood and HFpEF is often misdiagnosed. Remodeling and fibrosis stimulated by inflammation appear to be main factors for the progression of HFpEF. In contrast to patients with HF with reduced ejection fraction, medical treatment in HFpEF is limited to relieving HF symptoms. Since mortality in HFpEF patients remains unacceptably high with a 5-year survival rate of only 30%, new treatment strategies are urgently needed. Exercise seems to be a valid option. However, the optimal training regime still has to be elucidated. Therefore, the aim of the study is to investigate the effects of a high-intensity interval (HIT) training vs. a moderate continuous training (MCT) on exercise capacity and disease-specific mechanisms in a cohort of patients with HFpEF. Methods: The proposed study will be a prospective, randomized controlled trial in a primary care setting including 86 patients with stable HFpEF. Patients will undergo measurements of exercise capacity, disease-specific blood biomarkers, cardiac and arterial vessel structure and function, total hemoglobin mass, metabolic requirements, habitual physical activity, and quality of life (QoL) at baseline and follow-up. After the baseline visit, patients will be randomized to the intervention or control group. The intervention group (n = 43) will attend a supervised 12-week HIT on a bicycle ergometer combined with strength training. The control group (n = 43) will receive an isocaloric supervised MCT combined with strength training. After 12 weeks, study measurements will be repeated in all patients to quantify the effects of the intervention. In addition, telephone interviews will be performed at 6 months, 1, 2, and 3 years after the last visit to assess clinical outcomes and QoL. Discussion: We anticipate clinically significant changes in exercise capacity, expressed as VO2peak, as well as in disease-specific mechanisms following HIT compared to MCT. Moreover, the study is expected to add important knowledge on the pathophysiology of HFpEF and the clinical benefits of a training intervention as a novel treatment strategy in HFpEF patients, which may help to improve both QoL and functional status in affected patients. Trial registration: ClinicalTrials.gov, identifier: NCT03184311, Registered 9 June 2017.
Metabolic Energy Contributions During High-Intensity Hatha Yoga and Physiological Comparisons Between Active and Passive (Savasana) Recovery

Purpose: The objective of this study was to investigate metabolic energy contributions during high-intensity hatha yoga (HIHY) and to compare changes in physiological variables between active and passive recovery methods. Methods: The study involved 20 women yoga instructors (n = 20) who performed 10 min of HIHY (vigorous sun salutation). Upon completion, they were randomly assigned to either active (walking; n = 10) or passive (savasana; n = 10) recovery groups for a period of 10 min. During HIHY, physiological variables such as heart rate (HRpeak and HRmean), oxygen uptake (VO2peak and VO2mean), and blood lactate concentrations (peak La−) were measured. Energetic contributions (phosphagen; WPCR, glycolytic; WGly, and oxidative; WOxi) in kJ and % were estimated using VO2 and La− data. Furthermore, the metabolic equivalents (METs) of VO2peak and VO2mean were calculated. To compare different recovery modes, HRpost, ΔHR, VO2post, ΔVO2, recovery La−, and recovery ΔLa− were analyzed. Results: The results revealed that HRpeak, VO2peak, and peak La− during HIHY showed no differences between the two groups (p > 0.05). Values of HRpeak, HRmean, METs of VO2peak and VO2mean, and La− during HIHY were 95.6% of HRmax, 88.7% of HRmax, 10.54 ± 1.18, 8.67 ±. 98 METs, and 8.31 ± 2.18 mmol·L−1, respectively. Furthermore, WOxi was significantly higher compared with WPCR, WGly, and anaerobic contribution (WPCR + WGly), in kJ and % (p < 0.0001). VO2post and recovery ΔLa− were significantly higher in the active recovery group (p < 0.0001, p = 0.0369, respectively). Values of ΔVO2 and recovery La− were significantly lower in the active group compared with the passive group (p = 0.0115, p = 0.0291, respectively). Conclusions: The study concluded that high-intensity hatha yoga which was performed for 10 min is a suitable option for relatively healthy people in the modern workplace who may have hatha yoga experience but do not have time to perform a prolonged exercise. Following active recovery, they can participate in further HIHY sessions during short breaks. Furthermore, a faster return to work can be supported by physiological recovery.
Foliar Application or Seed Priming of Cholic Acid-Glycine Conjugates can Mitigate/Prevent the Rice Bacterial Leaf Blight Disease via Activating Plant Defense Genes

Xanthomonas Oryzae pv. oryzae (Xoo) causes bacterial blight and Rhizoctonia solani (R. solani) causes sheath blight in rice accounting for >75% of crop losses. Therefore, there is an urgent need to develop strategies for the mitigation of these pathogen infections. In this study, we report the antimicrobial efficacy of Cholic Acid-Glycine Conjugates (CAGCs) against Xoo and R. solani. We show that CAGC C6 is a broad-spectrum antimicrobial and is also able to degrade biofilms. The application of C6 did not hamper plant growth and showed minimal effect on the plant cell membranes. Exogenous application of C6 on pre-infection or post-infection of Xoo on rice susceptible genotype Taichung native (TN1) can mitigate the bacterial load and improve resistance through upregulation of plant defense genes. We further demonstrate that C6 can induce plant defense responses when seeds were primed with C6 CAGC. Therefore, this study demonstrates the potential of CAGCs as effective antimicrobials for crop protection that can be further explored for field applications.
Stability of MDS-UPDRS Motor Subtypes Over Three Years in Early Parkinson's Disease

Background: Various classifications have been proposed to subtype Parkinson's disease (PD) based on their motor phenotypes. However, the stability of these subtypes has not been properly evaluated. Objective: The goal of this study was to understand the distribution of PD motor subtypes, their stability over time, and baseline factors that predicted subtype stability. Methods: Participants (n = 170) from two prospective cohorts were included: the Early PD Longitudinal Singapore (PALS) study and the National Neuroscience Institute Movement Disorders Database. Early PD patients were classified into tremor-dominant (TD), postural instability and gait difficulty (PIGD), and indeterminate subtypes according to the Movement Disorder Society's Unified PD Rating Scale (MDS-UPDRS) criteria and clinically evaluated for three consecutive years. Results: At baseline, 60.6% patients were TD, 12.4% patients were indeterminate, and 27.1% patients were PIGD subtypes (p < 0.05). After 3 years, only 62% of patients in TD and 50% of patients in PIGD subtypes remained stable. The mean levodopa equivalent daily dose (LEDD) was higher in the PIGD subtype (276.92 ± 232.91 mg; p = 0.01). Lower LEDD [p < 0.05, odds ratio (OR) 0.99, 95% confidence interval (CI): 0.98–0.99] and higher TD/PIGD ratios (p < 0.05, OR 1.77, 95% CI: 1.29–2.43) were independent predictors of stability of TD subtype with an area under the curve (AUC) of 0.787 (95%CI: 0.669–0.876), sensitivity = 57.8%, and specificity = 89.7%. Conclusion: Only 50–62% of PD motor subtypes as defined by MDS-UPDRS remained stable over 3 years. TD/PIGD ratio and baseline LEDD were independent predictors for TD subtype stability over 3 years.
Data-Driven Mapping With Prediction Neural Network for the Future Wide-Swath Satellite Altimetry

Two-dimensional mapping of sea surface height (SSH) for future wide-swath satellite altimetry (WSA) is a challenge at present. So far, considering the utilization of data-driven methods is a new researching direction for SSH mapping. In general, the data-driven mapping methods rely on the spatial-temporal relationship of the observations. These methods require training in large volumes, and the time cost is high, especially for the WSA observations. This paper proposed the prediction neural networks for mapping (Mapping-PNN) method to improve the training efficiency and maintain stable data and mapping capabilities. By 10-year wide-swath satellite along track observing system simulation experiments (OSSEs) on the HYCOM data, the experiment results indicate that the method introduced in this paper can improve the training efficiency and meet the grid mapping expectations. Compared with other methods, the root mean squared error (RMSE) of the mapping-PNN method can be limited within the range of ~1.8 cm, and the new method can promote the observation of the ocean phenomena scale with < ~40 km, which reaches state of the art.
Moderate-Intensity Physical Exercise Affects the Exercise Performance and Gut Microbiota of Mice

The gut microbiota is closely associated with the health of the host and is affected by many factors, including exercise. In this study, we compared the gut microbial changes and exercise performance over a 14-week period in mice that performed exercise (NE; n = 15) and mice that did not perform exercise (NC; n = 15). Mice were subjected to stool collection and exercise tests one week prior to adaptive training and after 2, 6, 10, and 14 weeks of exercise. Bacteria associated with the stool samples were assessed via Illumina-based 16S rRNA gene sequencing. While there was no significant difference in body weight between the groups (p > 0.05), the NE group had a significantly higher exercise performance from weeks 2–14 (p < 0.01) and lower fat coefficient (p < 0.01) compared with the NC group. The Shannon index of the gut microbiota in the NC group was higher than that in the NE group at weeks 6 and 10, and the Chao1 index was higher than that in the NE group at week 14. Exercise performance positively correlated with the relative abundance of Phascolarctobacterium. Grouped time series data analysis demonstrated that Bifidobacteria, Coprococcus, and one unnamed genus in the Clostridiales order were significantly increased in the NE group, which correlated with increased glucose, flavonoid, arginine, and proline metabolism. In conclusion, moderate-intensity treadmill exercise significantly increased the exercise performance of mice and changed the core bacteria and bacterial metabolic activity. These results provide a reference for studying the effects of exercise intervention and exercise performance on the gut microbiota of mice.
Solid‐state structure of cyclic dipeptides: an X‐ray and computational study of cis‐ and trans‐diketopiperazines of N‐methyl‐phenylalanine with the thia‐pipecolic acids and thia‐prolines

Ten new crystal structures of cis and trans bicyclic diketopiperazines (DKPs) of thia-pipecolic acid (with sulfur in the β, γ or δ position) or thia-proline (with sulfur in the β or γ position) and N-methyl phenyl­alanine [(NMe)Phe]: cyclo[(β-S)Pip-(NMe)Phe], cyclo[(γ-S)Pip-(NMe)Phe], cyclo[(δ-S)Pip-(NMe)Phe], cyclo[(β-S)Pro-(NMe)Phe] and cyclo[(γ-S)Pro-(NMe)Phe] were determined with X-ray crystallography. Density functional theory calculations of these molecules in the gas phase succeed in reproducing the observed molecular conformations in the crystal remarkably well. This illustrates the weak to moderate impact of intermolecular packing forces in the absence of classical N—H⋯O hydrogen bonds. The effect of sulfur on the geometry of the DKP ring and details of amide bond non-planarity are discussed. Molecular flexibility of the DKP ring, as estimated from the calculated deformation energies of its endocyclic ring torsion angles, is not in general the decisive factor for the occurrence of multiple symmetry independent molecules in the unit cell (Z′ > 1), though in some cases a correlation is observed.
Bricks, clicks and Calk: Clustering services for citizen‐centred delivery

: Since the mid-1980s, the traditional “bricks-and-mortar” approach to delivering a single service through face-to-face contacts in government offices has been improved by the creation of one-stop walk-in centres that provide multiple services of a related or unrelated nature, by telephone call centres that provide both personal service and interactive voice response, and by the rapid growth of service delivery through the Internet. The challenge for governments is to determine how best to join up services within and between departments, across levels of government, between governmental and non-governmental service providers, and across channels. This article focuses on the delivery of government services by bringing them together in “clusters” and delivering them through more than one service channel. The article explains the concept of service clustering and provides a model of its major components; uses this model as a framework for describing innovative clustering initiatives in several countries; and examines the implications of service clustering for public administration, with particular reference to privacy and security issues. Sommaire: Depuis le milieu des annees 1980, I'approche traditionnelle brique et mortier adoptee pour la prestation d'un service unique par le biais de contacts personnels dans les bureaux du gouvernement a connu une amelioration avec la mise en place des guichets uniques qui offrent de nombreux services de nature connexe ou non, de centres d'appels telephoniques fournissant a la fois des services personnels et une reponse vocale interactive, et grâce au developpement rapide de la prestation de services par Internet. Pour les gouvernements, le defi consiste a determiner comment regrouper les services au sein d'un ministere et entre les ministeres, entre les paliers de gouvernement, entre les foumisseurs de services gouvernementaux et non gouvernementaux, et entre les mecanismes de prestation. Le present article se concentre sur la prestation des services gouvernementaux regroupes et fournis par l'intermediaire de plusieurs mecanismes de prestation. Il explique le concept de regroupement des services et presente un modele de ses principales composantes; il se sert de ce modele comme cadre pour decrire les initiatives innovatrices en matiere de regroupernent de services dans plusieurs pays; enfin, il examine les repercussions du regroupernent des services sur l'administration publique, en particulier du point de vue de la confidentialite et de la securite.
Mesomorphic phase transitions of 3F7HPhF studied by complementary methods

ABSTRACT Physical properties and the phase sequence of (S)-4′-(1-methylheptyloxycarbonyl)biphenyl-4-yl 4-[7-(2,2,3,3,4,4,4-heptafluorobutoxy) heptyl-1-oxy]-2-fluorobenzoate exhibiting the liquid crystalline paraelectric smectic A*, ferroelectric smectic C* and antiferroelectric smectic CA* phases were studied by complementary methods in the temperature range from −125 to 120 °C. Differential scanning calorimetry measurements together with polarizing optical microscopy provided the phase sequence, including the glass transition and a cold crystallization. X-ray diffraction was used to obtain the unit-cell parameters of the crystal phase, as well as the layer thickness and correlation length in the liquid crystalline smectic phases. The tilt angle was found to reach 45°, as determined from the measurements of the layer thickness and molecular modeling. Relaxation processes in the smectic phases and the fragility parameter were studied using frequency-domain dielectric spectroscopy.
Ethanolic Extract of Papaya (Carica papaya) Leaf Exhibits Estrogenic Effects In Vivo and In Silico

The menopause women have the low level of estrogen in the body. The lack of estrogen changes physiological function in women’s body that affects in health condition. Carica papaya L. leaf contains flavonoid quercetin which exhibits estrogenic effect. The aim of this study is to determine the estrogenic effect of papaya leaves extract (PLE) in vivo, and in silico . Papaya leaves were extracted by ethanol 70% maceration. The in silico study were done by molecular docking between quersetin and Estrogen Receptor (ERα and ERβ) to obtain the docking score. Based on this study, docking score of quercetin was almost similar to the native ligand of ER. The in vivo study was done as follow: 36 female rats Sprague Dawley divided into six groups. The groups are shame-ovariectomized (S-OVX), control ovariectomized (OVX), CMC-Na control (OVX+CMC-Na), positive control (OVX+Estradiol), and the PLE treatment groups dose 750 mg/kgBW (OVX+750mg/kgBW) and dose 1000 mg/kgBW (OVX+1000 mg/kgBW). Administrations of PLE were done in three weeks orally, while estradiol was administrated intraperitonially. The mammae and uterine were sliced for analysis. Based on the study, the treatment of PLE increased the number of mammae lobules and uterine weight as well as estrogen does. In summary, PLE can be developed as a source of phytoestrogens. Keywords: Carica papaya L. , phytoestrogen, estrogen receptor, mammae lobule, uterine
ETUDE DE L’INFLUENCE D’UN RECUIT SUR LA PASSIVITE D’UN ALLIAGE DE TITANE DANS UNE SOLUTION SALINE A 3,5% NaCl

Ce travail est focalise sur l’etude des performances physico-chimique d'alliages de titane biphase α+β (Ti-6Al-4V) au cours d’un recuit et sur la nature des produits de corrosion apres essai d’immersion. Les microstructures obtenues ont ete observees ainsi que des mesures de la microdurete HV afin d’estimer les modifications apportees. Le comportement a la corrosion dans une solution saline a 3,5% NaCl a ete analyse par des testes electrochimiques a savoir le suivi du potentiel en circuit ouvert, des essais potentiodynamiques et des testes de spectroscopies d’impedances electrochimiques suives parune analyse de diffraction au rayons X en incidence rasante afin d’identifie les d’oxydes formes en urface.
A New Era in the Management of Atopic Dermatitis

Atopic dermatitis is a notoriously itchy condition that has profound effects on patient quality of life. The pathophysiology of this disease involves immune dysregulation, genetics, and environmental triggers contributing to barrier dysfunction characteristic of this disease. With advances in knowledge of atopic dermatitis pathophysiology, novel drugs have changed the lives of many patients. Furthermore, as dermatologic diseases are often a large component of primary care, it is important for the nurse practitioner to be aware of updates in management. The purpose of this article is to provide an updated review on the treatment of atopic dermatitis including novel therapies.
MANAGEMENT OF PROGRESSIVE LUNG CANCER PATIENTS AFTER FIRST-LINE EGFR TYROSINE KINASE INHIBITOR THERAPY

Various tyrosine kinase inhibitor (TKI) drugs have been widely used as therapy for cancer that has EGFR mutations, or abnormal EGFR activation. However, patients who have a mutation in the gene that activates EGFR only benefit from EGFRTKI therapy for less than one year, because after that resistance occurs. In the management of patients according to NCCN 2017, patients who experience progress after receiving TKI as the first-line therapy must undergo an examination to identify the presence of T790M mutation. If the T790M mutation is positive, the choice of therapy that needs to be provided is the third generation (Osimertinib). Many recent studies have proved the significance of the effectiveness and response of Osimertinib therapy in lung cancer with EGFR T790M mutation. We reported the management of a pulmonary adenocarcinoma patient with positive EGFR mutation who had received first-line EGFR TKI who had progressive disease and T790M mutation in Dr. Seotomo Hospital. The patient finally received Osimertinib through an Early Access Program with a therapeutic response that improved significantly.
Changes in soil exchangeable nutrients across different land uses in steep slopes of Mizoram, North-east India

Land use change resulting from anthropogenic pressure on land has led to degraded soil quality, especially in the hilly tropical regions where ecosystems are generally fragile and susceptible to soil degradation from cultivation. Hence, sustainable land uses and management practices are crucial for agricultural production and ecological balance, particularly in these regions. The present study investigates the impact of various hill land uses (Natural forest-NAF, Jhum fallow-JF, Home garden-HG, Acacia pennata plantation-AP and Current Jhum-CJ) on soil exchangeable nutrients in steeply sloping agro-ecosystems of Mizoram, North-east India. Soil samples were collected from three different depths (0-10, 10-20 & 20-30 cm) and analyzed for pH, Pavail, Na, K, Mg, Mn and Ca. Our results indicated that land use and soil depths had a significant impact on soil pH, Pavail and soil exchangeable cations (p<0.05). Conversion of native forests for cultivation negatively affected soil properties as indicated by the reduced soil exchangeable cations in cultivated lands (AP & CJ) in relation to the natural forest (NAF) and Jhum fallow (JF). Soils under longer periods of fallow (>12 years) led to increases in soil available nutrients indicating the role of vegetation cover in conserving and enhancing soil available nutrients and vice-versa. In addition, Home garden (HG) showed moderately higher available soil nutrients signifying the role of sustainable management practices such as the addition of organic amendments and mixed cropping, leading to increased soil available nutrient content.