Miracle-dz/UniFAR-FTUs huggingface dataset:
MetaDTA: Meta-learning-based drug-target binding affinity prediction

We propose a meta-learning-based model for drug-target binding affinity prediction (MetaDTA), for which no information on the protein structures or binding sites is available. We formulate our method based on the At-tentive Neural Processes (ANPs) (Kim et al., 2019), where the binding affinities for each target protein are modeled as a regression function of the compounds. Known drug-target binding affinity pairs are used as support set data to determine the regression function. We designed few-shot prediction experiments with a small number of support set data, similar to the typical situations in actual drug discovery processes. Experimental results showed that the proposed method outperforms the sequence-based baseline models with the same amount of limited data.
Review: The potential of seminal ﬂ uid mediated paternal – maternal communication to optimise pregnancy success

fertilisationandassuchthemechanismstoestablishantigen-speci ﬁ ctolerancemustbeinitiatedveryearlyduringpregnancy. Weandothersproposethatthesemechanismsareinitiatedatthetimeofinseminationwhenpaternalantigensare ﬁ rstintroducedto thematernalimmunesystem.Itisunclearwhethersuchmechanismswouldalsobeinvolvedindomesticspecies,suchascattle, whereimplantationoccursweekslateringestation.Anewparadigmdetailingtheimportanceofpaternal – maternalcommunication atthetimeofinseminationisbecomingevidentasitrelatestomaternaltolerancetofoetalantigenandultimatelypregnancysuccess.
Effect of Sunflower Seed Oil Moisturizer Creams on Transepidermal Water Loss in Atopic Dermatitis Pediatric Patients

: Atopic dermatitis (AD) is a chronic disease associated with disruption of skin barrier. There is an increase of transepidermal water loss (TEWL) in AD, therefore moisturizers application is essential. Sunflower seed oil (SSO) is one of natural moisturizer contain essential fatty acid that has emollient and occlusive effect. The aim of this study was to ascertain the effect of SSO on TEWL in AD pediatric patients. A hundred and twenty-four pediatric subjects with and without history of AD recruited into one cross-sectional study and three randomize-controlled studies, including the measurement of TEWL on six anatomical sites, the effect of 15% SSO moisturizer cream in healthy skin, comparison of 15% SSO moisturizer cream to controlled, and comparison of 20% SSO moisturizer to 5% urea moisturizer cream in AD patients, respectively. The moisturizer was applied twice daily on forearm or lower leg for two weeks. The TEWL values was measured by Tewameter® 300. The result showed that the highest TEWL values on the extensor part of lower leg (10.72 g/m2/h). The application of 15% SSO moisturizer showed a positive impact on skin barrier by reducing TEWL value in healthy skin (average decrease 9.34 g/m2/h, p< 0.01). TEWL decrement value between 15% SSO group compared to controlled group were not significant (p= 0.283). While, TEWL decrement value of 20% SSO group had similar results compared to 5% urea group (p= 0.309). We concluded that 20% SSO can be used as an alternative and can work as well as urea on AD pediatric patients.
SEASONAL VARIATION IN AIRTIGHTNESS

Airtightness of buildings is necessary to obtain healthy, sustainable and energy efficient buildings. Measuring the airtightness of a building has become more common lately, much due to the higher energy use in leaky buildings. The airtightness of a building can for example be measured in order to attain a certification, or on demand from a developer. In some studies, there have been large seasonal variations in airtightness. In most cases, the buildings are more leaky in wintertime, but there are also some investigations that show the opposite. In the current project, the aim is to investigate how, and if, the airtightness varies over the year. The airtightness is measured, using a blower door, approximately eight times a year, in three different buildings. The air leakages in the buildings are also detected and the air velocities at a number of leakages are measured. Two of the buildings are one-family, two story, wooden frame houses and one is a multi-family, concrete building (where one apartment is measured). In Swedish wooden houses, the air barrier is often a polyethylene foil, which is also the case in these two buildings. The measurements have been analyzed with respect to indoor/outdoor temperature and indoor/outdoor relative humidity. The trend in the measurements is that the airtightness is lower (more leaky envelope) when the indoor air is drier (low relative humidity). Consequently, the air leakage is largest during the winter measurements. The decrease in airtightness from summer to winter is in the order of 8-10%.
High-performance zinc oxide thin-film transistors for large area electronics

Thin-film transistors (TFTs) based on metal oxide semiconductors are currently being studied as potential alternatives to silicon based technologies for electronic applications where low-cost, mechanical flexibility, large-area processing and optical transparency are required. Despite their relatively brief history, the charge carrier mobilities of state-of-the-art ZnO TFTs now exceeds those obtained from mainstream technologies such as hydrogenated amorphous silicon (a-Si:H) transistors, making metal oxide semiconductor technology a strong candidate for a whole host of future electronic applications. This chapter reviews the recent progress in the field of oxide semiconductor electronics with particular emphasis on materials and TFT performance. Current status of transparent oxides based electronics Chapter 2 25 2.
End of Life Management: Solar Photovoltaic Panels

Solar photovoltaic (PV) deployment has grown at unprecedented rates since the early 2000s. As the global PV market increases, so will the volume of decommissioned PV panels, and large amounts of annual waste are anticipated by the early 2030s. Growing PV panel waste presents a new environmental challenge, but also unprecedented opportunities to create value and pursue new economic avenues. This report, prepared jointly by the International Renewable Energy Agency (IRENA) and the International Energy Agency Photovoltaic Power Systems Programme (IEA-PVPS), is the first-ever projection of PV panel waste volumes to 2050. It highlights that recycling or repurposing solar PV panels at the end of their roughly 30-year lifetime can unlock an estimated stock of 78 million tonnes of raw materials and other valuable components globally by 2050. If fully injected back into the economy, the value of the recovered material could exceed USD 15 billion by 2050. Sectors like PV recycling will be essential in the world's transition to a sustainable, economically viable and increasingly renewables-based energy future. To unlock the benefits of such PV end-of-life industries, the institutional groundwork must be laid in time to meet the expected surge in panel waste. Policy action is needed to addressmore » the challenges ahead, with enabling frameworks being adapted to the needs and circumstances of each region or country. « less
Program Evaluation and Review: Online Training for Apprenticeship Trades

Due to the alleged skill shortage across Canada, Red River College in Winnipeg partnered with Apprenticeship Manitoba for the purpose of designing, developing and delivering an alternate model of program delivery for apprenticeship education comprised of distributed learning using hybrid or blended learning methodology. This case study identifies the experiences and recommendations of individuals associated with the project. This case study is significant as the literature is void of empirical data relating to any model of training delivery for apprenticeship training in Canada or elsewhere.
Longitudinal Bunch Shaping at Picosecond Scales using Alpha-BBO Crystals at the Advanced Superconducting Test Accelerator

The Integrable Optics Test Accelerator (IOTA) electron injector at Fermilab will enable a broad range of experiments at a national laboratory in order to study and develop solutions to the limitations that prevent the propagation of high intensity beams at picosecond lengths. One of the most significant complications towards increasing short-beam intensity is space-charge, especially in the vicinity of the gun. A few applications that require a longitudinally shaped electron beam at high intensities are for, the generation of THz waves and dielectric wakefields, each of which will encounter the effects of longitudinal space-charge. This paper investigates the effects of longitudinal space-charge on alpha-BBO UV laser shaped electron bunches in the vicinity of the 11⁄2cell 1.3 GHz cylindrically symmetric RF photocathode gun.
Seventh Grade Science and Technology Course Evaluation Activities in the unit of Human and Environment According to the Science Process Skills

This study is a comparison study between science process skill attainments that students built as a result of learning products in the implementation process of 7th grade Human and Environment Unit and the anticipated science process skill attainments in the science and technology curriculum. Sample of the study consists of 22 students enrolled in a primary school in 2007-2008 school years in Marmara District in Turkey. However, data of 11 students are used for this study. Data are gathered through document analysis, interviews and analysis of video recordings during the implementation of activities. Interviews are performed in order to determine science process skills that might be shown in outside the classroom activities such as homework. Results of the study showed that students are using more science process skills during the activities than indicated in the curriculum. These skills are listed as prediction and note taking, observation and filling in the form, classroom discussion, writing an essay and preparing a report. Summary
Optimization of 90 and120 dB- Shielding Effectiveness for Plane Electromagnetic Waves at Center Frequencies (3 and 3000) MHz

In this study, a MATLAB computer program has been prepared and developed in three dimension views for computing the total shielding effectiveness (SE) as a function of both shield thickness and incidence angle to evaluate the optimum shield thickness that provide (90 and 120 )dB shielding effectiveness for both transverse electric (TE) and transverse magnetic (TM) field, respectively. This investigation has been done using two sets of good conductor materials including non-magnetic materials [Copper and Aluminum] and a set of magnetic materials [Nickel and stainless steel] to identify which of them provide a thinner shield requirements for both TE and TM – modes at center frequencies of (3 and 3000) MHz.
Humanoid and its potential applications

Ministry of Economy, Trade and Industry (METI) of Japan had run an R&D project on humanoid robotics. We call it HRP. In the project, platforms for humanoid robotics research were developed at first and contributors of the project carried R&D on the applications of humanoid robots with consideration given to the needs of industries by using the platforms. In this paper, we describe the explored five applications that are suitable to use humanoid robots and expected to open new industry.
Examining organic acid production potential and growth‐coupled strategies in Issatchenkia orientalis using constraint‐based modeling

Growth‐coupling product formation can facilitate strain stability by aligning industrial objectives with biological fitness. Organic acids make up many building block chemicals that can be produced from sugars obtainable from renewable biomass. Issatchenkia orientalis is a yeast strain tolerant to acidic conditions and is thus a promising host for industrial production of organic acids. Here, we use constraint‐based methods to assess the potential of computationally designing growth‐coupled production strains for I. orientalis that produce 22 different organic acids under aerobic or microaerobic conditions. We explore native and engineered pathways using glucose or xylose as the carbon substrates as proxy constituents of hydrolyzed biomass. We identified growth‐coupled production strategies for 37 of the substrate‐product pairs, with 15 pairs achieving production for any growth rate. We systematically assess the strain design solutions and categorize the underlying principles involved.
Stigma, epistemic injustice, and “looked after children”: The need for a new language

Abstract This article examines the processes that contribute to the stigmatization of a group of people typically identified as “children in care” or “looked after children. ” In particular, we will look at the ways that we (adults, professionals, and carers) interact with these children, based on their status as both children and members of a socially marginalized and disadvantaged group, and how these modes of interaction can inhibit dialogue—a dialogue that is needed if we are to base our conceptions regarding the needs of these children on a more accurate understanding of their experiences and perspective. The problem is particularly challenging because the very terminology we use in the care community to identify this group is a product of the damaging preconceptions that have affected our interactions with its members and, we argue, it serves to reinforce those preconceptions. Using Fricker's work on epistemic injustice, in conjunction with evidence regarding how accusations of abuse and neglect of these children have been addressed in numerous cases, we illustrate the problems we have in hearing the voices of members of this group and the harmful effects this has on their own ability to understand and articulate their experiences. These problems represent “barriers to disclosure” that need to be surmounted if we are to establish a more inclusive dialogue. Currently, dialogue between these children and those of us charged to “look after” them is too often characterized by a lack of trust: not only in terms of the children feeling that their word is not taken seriously, that their claims are not likely to be believed, but also in their feeling that they cannot trust those to whom they might disclose abuse or neglect. The goals of the paper are modest in that we aim simply to open up the debate on how to meet this epistemic challenge, noting that there are specific problems that extend beyond those already identified for hearing the voices of other victims of epistemic injustice. Explicitly recognizing the nature and extent of the problem still leaves us a long way from its solution, but it is a crucial start.
Consecutive action of two BAHD acyltransferases promotes tetracoumaroyl spermine accumulation in chicory

Abstract Fully substituted phenolamide accumulation in the pollen coat of Eudicotyledons is a conserved evolutionary chemical trait. Interestingly, spermidine derivatives are replaced by spermine derivatives as the main phenolamide accumulated in the Asteraceae family. Here, we show that the full substitution of spermine in chicory (Cichorium intybus) requires the successive action of two enzymes, that is spermidine hydroxycinnamoyl transferase-like proteins 1 and 2 (CiSHT1 and CiSHT2), two members of the BAHD enzyme family. Deletion of these genes in chicory using CRISPR/Cas9 gene editing technology evidenced that CiSHT2 catalyzes the first N-acylation steps, whereas CiSHT1 fulfills the substitution to give rise to tetracoumaroyl spermine. Additional experiments using Nicotiana benthamiana confirmed these findings. Expression of CiSHT2 alone promoted partially substituted spermine accumulation, and coexpression of CiSHT2 and CiSHT1 promoted synthesis and accumulation of the fully substituted spermine. Structural characterization of the main product of CiSHT2 using nuclear magnetic resonance revealed that CiSHT2 preferentially catalyzed N-acylation of secondary amines to form N5,N10-dicoumaroyl spermine, whereas CiSHT1 used this substrate to synthesize tetracoumaroyl spermine. We showed that spermine availability may be a key determinant toward preferential accumulation of spermine derivatives over spermidine derivatives in chicory. Our results reveal a subfunctionalization among the spermidine hydroxycinnamoyl transferase that was accompanied by a modification of free polyamine metabolism that has resulted in the accumulation of this new phenolamide in chicory and most probably in all Asteraceae. Finally, genetically engineered yeast (Saccharomyces cerevisiae) was shown to be a promising host platform to produce these compounds.
webSCST: an interactive web application for single-cell RNA-sequencing data and spatial transcriptomic data integration

SUMMARY Integrative analysis of single-cell RNA-sequencing (scRNA-seq) data with spatial data for the same species and organ would provide each cell sample with a predictive spatial location, which would facilitate biological study. However, publicly available spatial sequencing datasets for specific species and organs are rare and are often displayed in different formats.In this study we introduce a new web-based scRNA-seq analysis tool, webSCST, that integrates well-organized spatial transcriptome sequencing datasets categorized by species and organs, provides a user-friendly interface for raw single-cell processing with popular integration methods, and allows users to submit their raw scRNA-seq data once to obtain predicted spatial locations for each cell type. AVAILABILITY AND IMPLEMENTATION webSCST implemented in shiny with all major browsers supported is available at http://www.webscst. com. webSCST is also freely available as an R package at https://github.com/swsoyee/webSCST.
Preliminary efficacy and safety analysis: 12-month results in 83 patients using a novel approach of widefield radiation therapy for extensive skin field cancerization with or without keratinocyte cancers

Abstract Purpose Evaluate the use of widefield radiation therapy (RT) in the management of extensive skin field cancerization (ESFC) with/without keratinocyte cancer (KC). Methods The National Dermatology Radiation Oncology Registry is a multidisciplinary collaboration (dermatologists and radiation oncologists). It captures disease description, prior therapies, radiation prescription, clinical effect, skin cosmesis scores, and toxicity data. This analysis included 12-month follow-up data on 89 treated fields from a subset of 83 patients. Results Clinical success (>90% field clearance) was 96% (ESFC, n = 63) and 88% (ESFC with KC, n = 26). Complete lesion response was seen in 96% of evaluable (n = 25) ESFC with KC. Recurrence (4/89 [5%]) and appearance of new lesions (10/89 [11%]) were minimal. Cosmetic outcome was excellent/good in 98% ESFC and 96% ESFC with KC. Grade 1–2 acute radiation dermatitis occurred in up to 80% of treated fields. The frequency of Grade 3 acute skin toxicities was low. Conclusions Registry data demonstrate the potential for widefield RT to treat patients with significant skin pathology who have exhausted other therapies and require durable, minimally invasive treatment options. At 12 months, observed clinical success rates were higher than those reported for topical interventions for ESFC. Ongoing follow-up is required to determine longer term outcomes.
Quality indicators in hemodialysis: A 5‐year experience of national campaigns in France

Background: End stage kidney disease (ESKD) is associated with increased morbidity and mortality. Hemodialysis (HD) is the main technique used for kidney replacement therapy. Dialyzed patients are expected to live less than one half as long as their counterparts without ESKD. Improving quality of care may help to improve mortality in this population. Methods: The French National Authority for Health has carried out three consecutive national campaigns over 5 years for the assessment of quality indicators (QCI) during HD. QCI included anemia management, iron status evaluation, nutritional status assessment, and annual transplantation access. Results: From 2013 to 2017, 227 health facilities participated, and 33,319 files were analyzed. Median age was 72 years old (IQR25–75 = 61–81), and 58.25% of patients were men. Median time in HD was 39.4 months (IQR25–75 = 20.7–72.7). Most of the patients underwent in‐center HD (85.41%). Overweight and obese patients accounted, respectively, for 28.39% and 21.32%, and malnutrition was present in 38.61%. A contra‐indication for renal transplantation was found in 68.3% of patients. All QCI improved over 5 years. Conclusion: Developing QCI based on guidelines is crucial to assure appropriate care of HD patients. Repeating campaigns over 5 years in France improves the quality of care among physicians.
Association between Community Violence, Disorder and School Environment with Bullying among School Adolescents in Sao Paulo – Brazil

The role of contextual-level factors in bullying is still not clear, and evidence is mostly from high-income countries. Our objective was to investigate the association between community violence, disorder, school environment and bullying among school adolescents. We used data from a representative sample of 9th grade Brazilian adolescents (n = 2108) from the Sao Paulo Project for the social development of children and adolescents (SP - PROSO). Multilevel logistic regression models stratified by sex were used to assess the association between variables at student and school/neighbourhood level and bullying victimization or perpetration. For both sexes, we found that adolescents who perceived high violence between students and high school disorder were more likely to be bullies and victims. Boys who perceived high community violence and disorder in their neighbourhood were more likely to be bullies (OR3tertile = 2.73 CI95%: 1.57–4.74). Girls attending schools where the principal reported high community violence and disorder in the neighbourhood (ORhigh = 10.24 CI95%: 2.11–49.59) and inside the school (ORhigh = 6.83 CI95%: 1.48–31.56) were more likely to be bullies. Boys from schools whose principal perceived violence between students were less likely to be victims (ORhigh = 0.35 CI95%: 0.16–0.78) and bullies (ORhigh = 0.21 CI95%: 0.07–0.64). Girls attending schools with signs or posters about tolerance/gender equality and about violence were less (OR = 0.12 CI95%: 0.03–0.50) and more likely (OR = 25.88 CI95%: 4.28–156.63) to report being bullies, respectively. Community violence, disorder and school environment were associated with bullying victimization and perpetration among adolescents. Sex-specific associations should be further investigated. Prevention and management of school violence in adolescence should consider contextual-level characteristics.
Trauma re-engagement and PTSD in older medically ill veterans: implications for trauma-informed care

Abstract Objectives We characterize rates and correlates of PTSD and of trauma re-engagement without PTSD in medically ill older Veterans, as well as supportive strategies, with the goal of advancing trauma-informed care. Methods We interviewed medically ill older Veterans (N = 88, M age 75.13, SD = 6.14) with primary care screening measures for PTSD and trauma re-engagement, and open-ended questions to assess supportive strategies. Results One-fifth (20.5%) presented with probable PTSD, associated with greater trauma exposures (r=.57, p<.001), whereas two-fifths (43.2%) reported re-engagement with military memories without PTSD, associated with having a spouse/partner (t = 2.27, p=.028). Of those who experienced trauma, half reported thinking more about the trauma recently and becoming more emotional on certain days. In response to the question ‘What gives you strength as you think about the future with your illness’ Veterans described support of family, healthcare, worldview, personal control, acceptance, and health behaviors. Conclusion Memories of trauma are common with medical illness. Age-friendly trauma-informed care could consider factors that patients describe as sources of strength with illness.