Miracle-dz/UniFAR-FTUs huggingface dataset:
A Multi-Axis Best Fit to the Collider Supersymmetry Search: The Aroma of Stops and Gluinos at the \sqrt{s} = 7 TeV LHC

In Profumo di SUSY, we presented evidence that CMS&ATLAS may have already registered a handful of deftly camouflaged supersymmetry events at the LHC in the multijet channels. Here, we explore the prospect for corroboration of this suggestion from 5 additional CMS&ATLAS search strategies targeting the production of light stops & gluinos at lower jet counts, which variously depend on heavy flavor tagging and the inclusion or exclusion of associated leptons. The current operating phase of the 7TeV LHC is highly conducive to the production of gluinos & light stops, given the supersymmetric particle mass hierarchy M_t_1<M_g<M_q that naturally evolves from the dynamics of the model named No-Scale FSU5 that we presently study. Moreover, some tension persists against the SM data-driven and MC generated background predictions in certain LHC searches of this variety. We demonstrate that the 1-sigma overlap of the allowed supersymmetric event production for these seven search methodologies roundly envelops the most favorable phenomenological subspace of FSU5, while handily generating a 125GeV Higgs boson mass. In order to test the statistical significance of any correlations across the simulated FSU5 collider response in these seven search strategies, we implement a multi-axis chi^2 fitting procedure, yielding a best overall match in the vicinity of M1/2=610GeV, corresponding to light stop & gluino masses of approximately 665GeV and 830GeV. Consequently, we suggest that FSU5 is a better global fit to the studied LHC data than the SM alone, and moreover that its predictions appear to be meaningfully correlated with observed low-statistics excesses across a wide variety of specialized search strategies. We suspect the already collected 5/fb will be sufficient to either condense or disperse the delicate aroma of stops and gluinos that suffuses the early search.
The centrosomal recruitment of γ-tubulin and its microtubule nucleation activity is α-fodrin guided

ABSTRACT The regulation and recruitment of γ-TuRCs, the prime nucleator of microtubules, to the centrosome are still thrust areas of research. The interaction of fodrin, a sub-plasmalemmal cytoskeletal protein, with γ-tubulin is a new area of interest. To understand the cellular significance of this interaction, we show that depletion of α-fodrin brings in a significant reduction of γ-tubulin in neural cell centrosomes making it functionally under-efficient. This causes a loss of nucleation ability that cannot efficiently form microtubules in interphase cells and astral microtubules in mitosis. Fluorescence Recovery after Photobleaching (FRAP) experiment implies that α-fodrin is important in the recruitment of γ-tubulin to the centrosome resulting in the aforementioned effects. Further, our experiments indicate that the interaction of α-fodrin with certain pericentriolar matrix proteins such as Pericentrin and CDK5RAP2 are crucial for the recruitment of γ-tubulin to the centrosome. Earlier we reported that α-fodrin limits the nucleation potential of γ-TuRC. In that context, this study suggests that α-fodrin is a γ-tubulin recruiting protein to the centrosome thus preventing cytoplasmic microtubule nucleation and thereby compartmentalizing the process to the centrosome for maximum efficiency. Summary statementα-fodrin is a γ-tubulin interacting protein that controls the process of γ-tubulin recruitment to the centrosome and thereby regulates the microtubule nucleation capacity spatially and temporally.
Mitochondrial respiratory complexes: Significance in human mitochondrial disorders and cancers

Mitochondria are pivotal organelles that govern cellular energy production through the oxidative phosphorylation system utilizing five respiratory complexes. In addition, mitochondria also contribute to various critical signaling pathways including apoptosis, damage‐associated molecular patterns, calcium homeostasis, lipid, and amino acid biosynthesis. Among these diverse functions, the energy generation program oversee by mitochondria represents an immaculate orchestration and functional coordination between the mitochondria and nuclear encoded molecules. Perturbation in this program through respiratory complexes' alteration results in the manifestation of various mitochondrial disorders and malignancy, which is alarmingly becoming evident in the recent literature. Considering the clinical relevance and importance of this emerging medical problem, this review sheds light on the timing and nature of molecular alterations in various respiratory complexes and their functional consequences observed in various mitochondrial disorders and human cancers. Finally, we discussed how this wealth of information could be exploited and tailored to develop respiratory complex targeted personalized therapeutics and biomarkers for better management of various incurable human mitochondrial disorders and cancers.
Role of interaction for caller satisfaction in telenursing-A cross-sectional survey study.

AIMS AND OBJECTIVES The aim of this study was to explore caller satisfaction with interaction, and the association to overall satisfaction with calls. BACKGROUND In the era of expanding healthcare at distance, the telephone remains a common tool for the provision of nursing care. Interaction between telenurse and caller in telenursing is vital for safety, satisfaction and adherence reasons. Few studies have quantitatively explored interaction in calls and how it relates to overall satisfaction with calls. DESIGN Cross-sectional survey study with a deductive approach. METHODS A total of 466 callers to the Swedish Medical Advisory Service completed the Telenursing Interaction and Satisfaction Questionnaire. Satisfaction with four theoretically defined components of interaction were compared using repeated measures ANOVA. Associations between satisfaction with interaction and overall satisfaction with calls were evaluated with ordinal logistic regression models with and without adjustment for age, sex, health status, waiting time, time for call, main result of the call and expectations. The study followed the STROBE checklist. RESULTS Callers were most satisfied with affective support, followed by professional-technical competence, health information and decisional control-in that order. A summated score of satisfaction with interaction was positively and significantly associated with overall satisfaction with calls before and after adjustment for waiting time, main result of call and variables related to the individual caller. CONCLUSIONS Caller satisfaction with interaction is generally high but can be improved, especially regarding decisional control. Satisfaction with interaction is important for overall satisfaction with calls. RELEVANCE TO CLINICAL PRACTICE This study provides support for professionals at all levels in telenursing organisations to pay attention to interactional matters. The development of best practice for telenurses needs to consider all four components of interaction to enhance satisfaction with calls.
On the Tachocline Zone Location in the Sun, the Luminosity Transport time scale, the Rotational Inertia and their Time Variation in Standard Solar Evolution Models

Studies with GONG Standard Solar Evolution Models sampling the evolution of the sun from its ZAMS stage show the following. The location of the tachocline zone is nearly fixed as it is not affected by shell burning although it co-moves with the expansion of the sun up to the present age of 4.6 Gyr. The luminosity transport time scale of the sun is entirely dominated by photon diffusion and during the evolution has decreased from over 204000 years to 187000 years. The rotational inertia of the sun shows a small gradual increase from
Identifiability of linear time-invariant differential-algebraic systems application of differential algebra

A system is identifiable if and only if the relationship between the parameters and the input-output behaviour of the system is unique. If a system is not identifiable, then accurate parameter estimation is not possible because identical input-output behaviour can be obtained for several values of the parameters. Most identifiability work in the literature has focused on ordinary differential equation (ODE) models. In this work we propose a method for testing linear time-invariant (LTI) differential-algebraic (DAE) systems for identifiability. Our method is computationally efficient, allows the treatment of systems that are nonlinear in the parameters, and allows the construction of an identifiable realization of the system.
Using cosmic microwave background radiation analysis tools for flow anisotropies in relativistic heavy-ion collisions

Recently we have shown that there are crucial similarities in the physics of cosmic microwave background radiation (CMBR) anisotropies and the flow anisotropies in relativistic heavy-ion collision experiments (RHICE). We also argued that, following CMBR anisotropy analysis, a plot of root-mean-square values of the flow coefficients, calculated in a laboratory-fixed frame for RHICE, can yield important information about the nature of initial state anisotropies and their evolution. Here we demonstrate the strength of this technique by showing that elliptic flow for noncentral collisions can be directly determined from such a plot without any need for the determination of the event plane.
Spin-selective tunneling from nanowires of the candidate topological Kondo insulator SmB6

Incorporating relativistic physics into quantum tunneling can lead to exotic behavior such as perfect transmission through Klein tunneling. Here, we probed the tunneling properties of spin-momentum-locked relativistic fermions by designing and implementing a tunneling geometry that uses nanowires of the topological Kondo insulator candidate samarium hexaboride. The nanowires are attached to the end of scanning tunneling microscope tips and used to image the bicollinear stripe spin order in the antiferromagnet Fe1.03Te with a Neel temperature of about 50 kelvin. The antiferromagnetic stripes become invisible above 10 kelvin concomitant with the suppression of the topological surface states in the tip. We further demonstrate that the direction of spin polarization is tied to the tunneling direction. Our technique establishes samarium hexaboride nanowires as ideal conduits for spin-polarized currents. Description Nanowire tip probes magnetism The material samarium hexaboride (SmB6) has been predicted to be a topological insulator that also features strong electronic correlations. Topological insulators exhibit so-called spin-momentum locking, which has been put to use in spintronics applications. Aishwarya et al. exploited these properties to achieve spin-polarized tunneling through a scanning tunneling microscope (STM) tip. The researchers mounted an SmB6 nanowire onto a trimmed tungsten tip. This combined tip was then used to image the magnetic state in the material Fe1+xTe. Unlike conventional spin-polarized STM, the authors’ setup does not require the application of an external magnetic field, which makes for a less-invasive probe. —JS A scanning tunneling microscope equipped with a samarium hexaboride (SmB6) nanowire tip is used to image magnetism in Fe1+xTe.
Roughness Suppression in Electrochemical Nanoimprinting of Si for Applications in Silicon Photonics

Metal‐assisted electrochemical nanoimprinting (Mac‐Imprint) scales the fabrication of micro‐ and nanoscale 3D freeform geometries in silicon and holds the promise to enable novel chip‐scale optics operating at the near‐infrared spectrum. However, Mac‐Imprint of silicon concomitantly generates mesoscale roughness (e.g., protrusion size ≈45 nm) creating prohibitive levels of light scattering. This arises from the requirement to coat stamps with nanoporous gold catalyst that, while sustaining etchant diffusion, imprints its pores (e.g., average diameter ≈42 nm) onto silicon. In this work, roughness is reduced to sub‐10 nm levels, which is in par with plasma etching, by decreasing pore size of the catalyst via dealloying in far‐from equilibrium conditions. At this level, single‐digit nanometric details such as grain‐boundary grooves of the catalyst are imprinted and attributed to the resolution limit of Mac‐Imprint, which is argued to be twice the Debye length (i.e., 1.7 nm)—a finding that broadly applies to metal‐assisted chemical etching. Last, Mac‐Imprint is employed to produce single‐mode rib‐waveguides on pre‐patterned silicon‐on‐insulator wafers with root‐mean‐square line‐edge roughness less than 10 nm while providing depth uniformity (i.e., 42.9 ± 5.5 nm), and limited levels of silicon defect formation (e.g., Raman peak shift < 0.1 cm−1) and sidewall scattering.
Modulation of the mammalian GABAA receptor by type I and type II positive allosteric modulators of the α7 nicotinic acetylcholine receptor

Positive allosteric modulators of the α7 nicotinic acetylcholine (nACh) receptor (α7‐PAMs) possess promnesic and procognitive properties and have potential in the treatment of cognitive and psychiatric disorders including Alzheimer's disease and schizophrenia. Behavioural studies in rodents have indicated that α7‐PAMs can also produce antinociceptive and anxiolytic effects that may be associated with positive modulation of the GABAA receptor. The overall goal of this study was to investigate the modulatory actions of selected α7‐PAMs on the GABAA receptor.
Distinct neuroanatomical correlates of interference-related verbal episodic memory test in healthy older adults

ABSTRACT Verbal learning test can include a trial of interference process that intrude initial learning and impose additional cognitive stress. However, it has been unclear whether the multiple memory processes underly different brain structural bases. We measured performances of word retrieval that represents distinct memory processes (initial learning, interference, and retention) and regional gray matter morphology from 230 cognitively unimpaired older adults. We identified three distinct multivariate pattern modes using canonical correlation analysis that map correspondence between memory and brain morphometry. The first mode comprised weights highly loaded on temporal lobe and overall performances. The second mode reflected subcortical volumes and initial learning performances. The third mode comprised thickness in the lateral prefrontal and parietal cortex and captured an ability to resist retroactive interference effect. While overall test performance reflected the temporal lobe and whole-gray matter volume, the interim trial of interference signifies neural correlates extending to subcortical and frontoparietal regions.
The Study of Deep Eutectic Solvent Based on Choline Chloride and l-(+)-Tartaric Acid Diethyl Ester for Transdermal Delivery System

Deep eutectic solvents (DESs) based on choline chloride (C) and l-(+)-tartaric acid diethyl ester (L) were prepared and used in transdermal drug delivery system (TDDS). The internal chemistry structure including the formation and changes of hydrogen bonds of choline chloride and l-(+)-tartaric acid diethyl ester DES was characterized via attenuated total reflection Fourier transform infrared (ATR-FTIR) and 1H nuclear magnetic resonance (1H NMR) spectroscopy. The stoichiometric ratio of choline chloride to l-(+)-tartaric acid diethyl ester as well as water content affected the viscosity, glass transition temperature (Tg), and drug solubility of the DES. The viscosity and glass transition temperature of the DES (CL14) prepared at the ratio of 1:4 of choline chloride to l-(+)-tartaric acid diethyl ester were 1.19 Pa·s and − 44.01°C, respectively, and decreased to 0.10 Pa·s and − 55.31°C when 10% water (CL1410) was added. Taking diclofenac diethylamine (DDEA), the nonsteroidal anti-inflammatory drug as model, drug solubility was as high as 60 mg/ml and 250 mg/ml in CL14 and CL1410, respectively. The cumulative amount of DDEA was 4.63 ± 2.67 μg/cm2 and 15.27 ± 4.63 μg/cm2 for CL14 and CL1410, respectively, at 8 h. The mechanism of percutaneous permeability by the DES may be the disturbance of stratum corneum (SC) lipids as well as changes in the protein conformations. CL14 and CL1410 were also verified as low-cytotoxic and nonirritant. Therefore, the DESs studied are promising to be used in drug solubilization enhancement and transdermal drug delivery system.
End-to-End Continuous/Discontinuous Feature Fusion Method with Attention for Rolling Bearing Fault Diagnosis

Mechanical equipment failure may cause massive economic and even life loss. Therefore, the diagnosis of the failures of machine parts in time is crucial. The rolling bearings are one of the most valuable parts, which have attracted the focus of fault diagnosis. Many successful rolling bearing fault diagnoses have been made based on machine learning and deep learning. However, most diagnosis methods still rely on complex signal processing and artificial features, bringing many costs to the deployment and migration of diagnostic models. This paper proposes an end-to-end continuous/discontinuous feature fusion method for rolling bearing fault diagnosis (C/D-FUSA). This method comprises long short-term memory (LSTM), convolutional neural networks (CNN) and attention mechanism, which automatically extracts the continuous and discontinuous features from vibration signals for fault diagnosis. We also propose a contextual-dependent attention module for the LSTM layers. We compare the method with the other simpler deep learning methods and state-of-the-art methods in rolling bearing fault data sets with different sample rates. The results show that our method is more accurate than the other methods with real-time inference. It is also easy to be deployed and trained in a new environment.
Systematic pan-cancer analysis identifies CDC45 as having an oncogenic role in human cancers

Cell division cycle 45 (CDC45) is an essential protein required for the initiation of DNA replication. In the present study, the role of CDC45 across 33 cancers was systematically investigated. It was observed that the expression of CDC45 was significantly upregulated in most cancers, exhibiting a marked negative correlation with the overall survival. Next, there was no significant difference in prognosis between the genomically altered and unaltered groups with respect to clinical outcomes. A decreased level of CDC45 at the DNA promoter region was also identified in several cancers. Furthermore, CDC45 expression was associated with the levels of tumor-infiltrating immune cells in some specific cancer types. In addition, CDC45 was associated with m6A methylation, and CDC45 expression was primarily positively correlated with ‘writers’ and ‘readers’ in various cancers, particularly HNRNPC, RBM15 and YTHDC1. Gene enrichment analysis was also performed. In addition, the AUC of each cancer with respect to its 1-, 3-, and 5-year survival rates were explored. Finally, CCK-8 assays, EdU assays and cell cycle analysis were conducted. In conclusion, the present study demonstrated that CDC45 may be a potential biomarker and target for cancer treatment.
Synthesis of ring-A modified lupeol derivatives and their anti-proliferative activity: identification of potent lead active against MCF-7 breast cancer cells

Abstract In continuation of our research program aimed at the development of new natural product-based anticancer agents, a series of lupeol derivatives (5a-5k and 6a-6i) were prepared with the introduction of aryl functionalities and amino acids at C-3 position. All the synthesised derivatives were assessed for in vitro anticancer activity against four human cancer cell lines using MTT assay. Interestingly, the compounds 5j, 5k, and 6 g showed potent activity against MCF7 cells as compared with the parent compound. Further, the flowcytometry analysis revealed that the 5j,5k, and 6 g arrest the cells at the G2/M phase and induce the early apoptosis in MCF7 cells. In addition, the selected compounds inhibit the BcL2 expression and increase the Bax protein expression in MCF7 cells. Overall, these results indicated that the lupeol derivatives could serve as a promising launch point for the development of anticancer agents. Graphical Abstract
Comparative assessment of a 1.5T endorectal coil and a 3.0T phased-array coil available for prostate MRI

The effectiveness of 3.0T phase array coil images was tested by comparing signal-to-noise ratios for the same coil images relative to 1.5T endorectal coil images. Signal intensities were measured in the three regions of prostate, central and peripheral (right and left) after 40 patients with prostate cancer were imaged during the period between Jan. 2008 and Oct. 2009 with T2 W, T1 W, and DW images obtained respectively using endorectal coil on a 1.5T MR scanner and phase array coil on a 3.0T MR scanner. For quantitative analysis, comparisons of average SNRs for the same ROIs were made between groups scanned with a 1.5T and a 3.0T MR scanner. The signal-to-noise ratios were shown to increase more sharply when using a phase array coil at a 3.0T MR scanner compared to using an endorectal coil at a 1.5T MR scanner.
Blood Pressure Classification Using the 2017 ACC/AHA Guideline and Heart Failure in Patients With Cancer

PURPOSE Despite the growing recognition of the importance of hypertension in patients with cancer, little is known about whether high blood pressure (BP) among patients with cancer is associated with incident heart failure (HF) and other cardiovascular disease (CVD) events and what BP levels are linked to these events. We examined the association of BP classification on the basis of the 2017 American College of Cardiology/American Heart Association BP guideline with the risk of HF and CVD events in patients with cancer. METHODS We studied 33,991 patients with a history of breast, colorectal, or stomach cancer (median age, 53 years; 34.1% men). Patients receiving treatment with BP-lowering medications or having a history of CVD including HF were excluded. Using BP measurements at baseline, 33,991 participants were categorized as having normal BP (n = 17,444), elevated BP (n = 4,733), stage 1 hypertension (n = 7,502), or stage 2 hypertension (n = 4,312). The primary outcome was HF. RESULTS Over a mean follow-up of 2.6 ± 2.2 years, 779 HF events were recorded. After multivariable adjustment, the hazard ratios (HRs) for HF were 1.15 (95% CI, 0.93 to 1.44) for elevated BP, 1.24 (95% CI, 1.03 to 1.49) for stage 1 hypertension, and 1.99 (95% CI, 1.63 to 2.43) for stage 2 hypertension. A stepwise increase in risk with BP categories was also observed in other CVD events. This association was observed even in patients undergoing active cancer treatment. The relationship between hypertension and the risk of developing HF in patients with cancer was confirmed in the Korean National Health Insurance Service database. CONCLUSION Medication-naïve stage 1 and 2 hypertension was associated with a greater risk of HF and other CVD events in patients with cancer. Our results suggest the importance of multidisciplinary collaboration (eg, oncologists and cardiologists) to establish the optimal management strategy for hypertension in patients with cancer.
Outcomes of a Data-Driven Physician Practice Redesign

This study evaluated a practice redesign to improve access into a specialty practice. The secondary goal was to improve financial performance, while avoiding an increase in physician burnout. Historical demand was utilized to calculate capacity. Next, data-driven schedules were developed for this practice. We also transitioned schedules from five 8-hour to four 10-hour workdays. Access was improved for news (100% increase), consultations (16% increase), and procedures (70% increase). Gross revenue increased by 10.62% and physician burnout reduced by 25%. This project offers insights into improving the efficiency of a resource-constrained practice, while improving financial performance and reducing burnout.