Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification, evaluation, and construction of potential leftover spaces based on parametric design platform: a study of Daxiaoma block in Guangzhou

In the urban renewal context, the leftover spaces in the city need to be uncovered and utilized. However, the existing studies on urban leftover spaces are still inadequate, particularly in the construction of leftover spaces. These studies are mainly based on qualitative and theoretical suggestions, lacking quantitative index-oriented decision-making suggestions. With the extensive integration of the Rhino + Grasshopper parametric platform with urban design, the application of such techniques to the identification and evaluation of leftover spaces could be conducted. Given the above research gap, this study used the parametric platform to measure the spatial type, pedestrian flow potential, and thermal comfort of leftover spaces to identify potential leftover spaces. Then, this study provided specific design recommendations for their spatial construction based on multiple leftover spaces evaluation indicators. The model constructed in this study is helpful to excavate urban leftover spaces with utilization potential at a small spatial scale, such as a block. This model can also provide a scientific design assistance reference, which is an effective tool to improve urban land use efficiency and urban space quality.
Prevalence and risk factors of anxiety and depression in adult patients with epilepsy: a multicenter survey-based study

Background: Depression and anxiety are the most common psychiatric comorbidities in patients with epilepsy (PWE). However, they are often unrecognized and consequently untreated. Objective: The study was conducted to evaluate the prevalence and risk factors of anxiety and depression among Chinese adult PWE. Design: Cross-sectional study. Methods: Adult PWE were recruited from 13 tertiary epilepsy centers from February to September 2022. Generalized Anxiety Disorder-7 and Neurological Disorders Depression Inventory for Epilepsy were applied to evaluate anxiety and depression, respectively. Both univariate and multivariate logistic regression analyses models were performed to explore the risk factors of anxiety and depression. Results: A total of 1326 PWE were enrolled in this study. The prevalence of anxiety and depression was 31.45% and 27.30%, respectively. Being female [odds ratio (OR) = 1.467, 95% CI: 1.134–1.899; p = 0.004], focal and focal to bilateral tonic-clonic seizures (TCSZ) (OR = 1.409, 95% CI: 1.021–1.939; p = 0.036), and seizure occurrence in the last 3 months (OR = 1.445, 95% CI: 1.026–2.044; p = 0.036) were the risk factors for anxiety. Focal and focal to bilateral TCSZ (OR = 1.531, 95% CI: 1.094–2.138; p = 0.013) and seizure occurrence in the last 3 months (OR = 1.644, 95% CI: 1.130–2.411; p = 0.010) were the risk factors for depression. In addition, for every 1-year increment of age, the odds of developing depression were decreased by 3.8% (p = 4.12e−5). Nevertheless, up to 70% of PWE did not receive any treatment for comorbidity. Conclusion: There were approximately 30% of PWE screened positive for anxiety or depression. Both focal and focal to bilateral TCSZ and seizure occurrence in the last 3 months were estimated as risk factors for anxiety and depression. However, the current status of treatment was not optimal.
Smoking status and its relationship with depression among the elderly population in Malaysia: Findings from the National Health and Morbidity Survey 2018

INTRODUCTION Literature exploring smoking status and its association with depression among the elderly population using nationwide data in Malaysia is limited. Hence, a nationwide survey to determine the prevalence of smoking and depression among the elderly (aged ≥60 years) population was undertaken. METHODS This secondary dataset analysis used data from the National Health and Morbidity Survey (NHMS) 2018. Data from 3914 participants were collected on elderly health in the Malaysian population. Sociodemographic characteristics were recorded. Smoking status was grouped as current smokers, former smokers, and non-smokers. A validated Malay language version of the Geriatric Depression Scale (M-GDS-14) was used to screen for depression among the elderly. RESULTS There was a significant association between smoking status with location, gender, employment status, marital status, ethnicity, education level, income, and depression. Current smokers are significantly higher in rural than urban areas. Among depressed participants, 65.7%, 17.1% and 17.2% were non-smokers, former smokers and current smokers, respectively. Multiple logistic regression showed that single (unmarried/separated/ divorced/widowed) participants were more likely to be depressed compared to married participants (AOR=1.68; 95% CI: 1.16–2.43). Whilst unemployed participants were more likely to be depressed than those who were employed (AOR=1.72; 95% CI: 1.22–2.44). Other Bumiputras were more likely to have depression compared to Malay, Chinese and Indian participants. Participants without formal education were more likely to be depressed compared to those having tertiary education. These participants have a 2-fold increased risk of depression (AOR=2.13; 95% CI: 1.02–4.45). Participants whose monthly salaries were <2000 MYR (AOR=3.67; 95% CI: 1.84–7.31) and 1000–1999 MYR (AOR=2.71; 95% CI: 1.23–5.94) were more likely to have depression compared with those who had received ≥3000 MYR. Ever smokers were more likely to be depressed than non-smokers (AOR=1.68; 95% CI: 1.23–2.29). CONCLUSIONS Elderly Malaysians are indeed at risk of developing depression particularly if they had ever smoked. Public health awareness and campaigning are pertinent to disseminate these outcomes in order to spread the awareness associated with smoking-related depression.
Five Reasons Why Some Herniated Intervertebral Discs are Painless

Abstract Herniated intervertebral discs (HIVDs) can cause lower back pain and leg pain, but not all cases are painful. We suggest five potential reasons for painless HIVDs. First, when inflammation resolves or is insufficient, pain may not occur. Second, rare cases exhibit motor or sensory deficits without pain, suggesting a mechanical rather than inflammatory component. Third, changes in gene expression within the dorsal root ganglia may prevent persistent inflammation and pain. Fourth, reorganization of neural circuits in the spinal dorsal horn can reduce nociceptive signals and lead to painlessness. Fifth, effective pain coping strategies and higher pain tolerance may mask any discomfort. Understanding these factors can improve clinicians’ knowledge and aid in pain management.
Xerophytic Lichens from Gypsiferous Outcrops of Arid Areas of Andalusia as a Source of Anti-Phytopathogenic Depsides

In a survey to evaluate the potential of lichens associated with gypsum areas as sources of new antifungal metabolites, six species of lichens were collected in the gypsum outcrops of the Sorbas Desert (Diploschistes ocellatus and Seirophora lacunosa) and the Tabernas Desert (Cladonia foliacea, Acarospora placodiformis, Squamarina lentigera and Xanthoparmelia pokornyi) in southern Spain. Raw lichen acetone extracts were tested against a panel of seven phytopathogenic fungi, including Botrytis cinerea, Colletotrichum acutatum, Fusarium oxysporum f.sp cubense TR4, Fusarium ploriferaum, Magnaporthe grisea, Verticillium dahliae and Zymoseptoria tritici. Active extracts of Cladonia foliacea, Xanthoparmelia pokornyi and Squamarina lentigera were analyzed by HPLC-MS/MS and Molecular Networking to identify possible metabolites responsible for the antifungal activity. A total of ten depside-like metabolites were identified by MS/MS dereplication and NMR experiments, of which one was a new derivative of fumaroprotocetraric acid. The compounds without previously described biological activity were purified and tested against the panel of fungal phytopathogens. Herein, the antifungal activity against fungal phytopathogens of 4′-O-methylpaludosic acid, divaricatic acid and stenosporic acid is reported for the first time. Stenosporic and divaricatic acids displayed a broad antifungal spectrum against seven relevant fungal phytopathogens in a micromolar range, including the extremely resistant fungus F. oxysporum f. sp. cubense Tropical Race 4 (TR4). 4′-O-methylpaludosic acid exhibited specific antifungal activity against the wheat pathogen Z. tritici, with an IC50 of 38.87 µg/mL (87.1 µM) in the absorbance-based assay and 24.88 µg/mL (55.52 µM) in the fluorescence-based assay.
Strategies for combating climate change in drylands agriculture: Synthesis of dialogues and evidence presented at the International Conference on Food Security in Dry Lands, Doha, Qatar, November, 2012

Changes in climate patterns are having their most acute effect on people living in the world’s dry areas and marginal lands. As these rural communities are largely dependent on agriculture for their livelihoods, it follows that improvements in agricultural research and 'integrated agro-ecosystem' approaches are probably the primary protection from climate related problems. This is also why agricultural innovation, research, technology transfer and capacity building should be strategic priorities of the UNFCCC. Strategies for Combating Climate Change in Drylands Agriculture The case for agriculture as a strategic solution to climate change in rural areas.
Axisymmetric rotating flow with free surface in a cylindrical tank

The flow induced by a disk rotating at the bottom of a cylindrical tank is characterised using numerical techniques – computation of steady solutions or time-averaged two-dimensional and three-dimensional direct simulations – as well as laser-Doppler velocimetry measurements. Axisymmetric steady solutions reveal the structure of the toroidal flow located at the periphery of the central solid body rotation region. When viewed in a meridional plane, this flow cell is found to be bordered by four layers, two at the solid boundaries, one at the free surface and one located at the edge of the central region, which possesses a sinuous shape. The cell intensity and geometry are determined for several fluid-layer aspect ratios; the flow is shown to depend very weakly on Froude number (associated with surface deformation) or on Reynolds number if sufficiently large. The paper then focuses on the high Reynolds number regime for which the flow has become unsteady and three-dimensional while the surface is still almost flat. Direct numerical simulations show that the averaged flow shares many similarities with the above steady axisymmetric solutions. Experimental measurements corroborate most of the numerical results and also allow for the spatio-temporal characterisation of the fluctuations, in particular the azimuthal structure and frequency spectrum. Mean azimuthal velocity profiles obtained in this transitional regime are eventually compared to existing theoretical models.
Exploring the Therapeutic Potential of Ethyl 3-Hydroxybutyrate in Alleviating Skeletal Muscle Wasting in Cancer Cachexia

Cachexia (CAC) is a debilitating metabolic syndrome. Although dietary interventions are attractive, long-term adherence to specific diets is difficult to maintain and can lead to systemic side effects. Ethyl 3-hydroxybutyrate (EHB) is a commonly used food additive found in wine and Tribolium castaneum. In this study, we investigated the effects of EHB administration in cachectic mice. After a single intraperitoneal injection of EHB into mice, 3-hydroxybutyrate (3-HB) levels were significantly increased in the serum and gastrocnemius of mice. The administration of EHB alleviated cachexia-related symptoms, ameliorated skeletal muscle atrophy, and improved survival in cachectic mice. In addition, the supplementation of cachectic mice with 3-HB by EHB administration significantly reduced tumor weights, indicating the anti-tumor effects of 3-HB. Remarkably, the addition of 3-HB to the culture medium significantly attenuated the C2C12 myotube atrophy induced by the culture supernatant of CT26 cell lines, highlighting its potential to counteract the destructive effects of tumor-derived elements on muscle tissue. NMR-based metabolomics analysis provided insights into the underlying mechanisms and revealed that the anti-cachexia effects of 3-HB treatment can be attributed to three key mechanisms: the promotion of the TCA cycle and the attenuation of proteolysis, the promotion of protein synthesis and the improvement of metabolic homeostasis, and a reduction in inflammation and an enhancement of the antioxidant capacity. This study provided compelling evidence for the protective effects of 3-HB treatment on the cachectic gastrocnemius and highlighted the efficacy of EHB administration as a ketone supplementation approach to achieve nutritional ketosis without the need for dietary restriction.
Scurvy and food selectivity in childhood: a case report

ABSTRACT Despite its rarity, symptomatic micronutrient deficiency remains a public health problem. Scurvy is the differential diagnosis for bleeding disorders and hematological and rheumatological diseases, especially in patients with eating disorders. However, it is unrelated to autism spectrum disorders or other neurodevelopmental disorders. A previously healthy 10-year-old boy living in São Paulo, Brazil, had a history of significant food selectivity unrelated to autism spectrum disorder, resulting in symptomatic ascorbic acid deficiency (scurvy). This resulted in pain and purpuric lesions on the lower limbs, gingival edema, bleeding during tooth brushing, asthenia, weakness, malaise, and sadness. Therefore, dietary anamnesis is important for routine monitoring of child growth and development. This process helps prevent nutritional deficiencies, facilitates early diagnosis of eating disorders, and enables multidisciplinary follow-up for these patients.
Addressing the Spatiotemporal Patterns of Heatwaves in Portugal with a Validated ERA5-Land Dataset (1980–2021)

This study presents a comprehensive analysis of heatwaves in mainland Portugal from 1 October 1980 to 30 September 2021 (41 hydrological years). It addresses a research gap by providing an updated assessment using high-resolution reanalysis daily minimum and maximum temperature data (Tmin and Tmax) from the gridded ERA5-Land dataset, overcoming the lack of publicly available daily temperature records. To assess the representation of the previous dataset, nine different grid-point locations across the country were considered. By comparing monthly ERA5-Land temperature data to ground-based records from the Portuguese Met Office, a monthly validation of the data was conducted for the longest common period, demonstrating good agreement between the two datasets. The heatwave magnitude index (HWMI) was employed to establish the temperature thresholds and thus identify heatwaves (defined as three or more consecutive days above the threshold). With over 640 Tmin heatwave days recorded at each of the nine ERA5-Land grid-points, data analysis revealed a discernible upward trend in Tmin heatwaves. The grid-point situated in the capital city’s urban area, i.e., Lisbon, exhibited the highest number of Tmin heatwave days. With an average of more than 800 Tmax heatwave days over the 41-year period, the northern and interior regions of Portugal had the greatest number of occurrences, reaching up to 916. A kernel rate estimation method was applied to further investigate the annual frequency of Tmin and Tmax heatwave occurrences. Results exhibited clear temperature changes, with a widespread increase in the number of heatwave days over the past two decades, particularly for Tmax. In summary, the occurrence of this phenomenon displayed significant spatial variations, with the southern interior and coastal grid-points experiencing a greater increase in annual Tmax heatwave days, rising from 10 to 30 between 2018 and 2019.
Doping impacts of La2O3 on physical, structural, optical and radiation shielding properties of (30-x)BaCO3–30TiO2–40SiO2-xLa2O3 (0 ≤ x ≤ 6) glasses for optoelectronic applications

Herein, synthesis of novel barium silicate glasses doped with La2O3 in the system (30-x)BaCO3–30TiO2–40SiO2-xLa2O3, BTSL (0 ≤ x ≤ 6) via fast melt-quenching technique was carried out. Further, to confirm the amorphous behaviour of prepared glass samples, x-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM) were carried out. The density of all prepared glasses was determined using Archimedes’ principle and found to be in an increasing manner. To investigate the doping influence of La2O3 on the glasses, few more physical properties like molar volume (Vm), polaron radius (rp), and field strength (Fs) were also studied and found to be increased due to incorporation of La2O3 into BTSL glassy system. Moreover, to explore the structural, functional, and bonding mechanism of the glasses, FTIR, Raman and 29Si-MAS-ssNMR spectroscopies were performed. Further, to investigate the numerous optical parameters, UV–visible spectroscopy was executed, and energy band gaps were found in the decreasing manner as increasing the La2O3 concentrations. Additionally, to study the optoelectronic properties, refractive indices (η) and optical dielectric constant (ε) were determined and revealed the increasing behaviour and found suitable material for optoelectronic devices. Furthermore, the radiation shielding parameters, mass attenuation coefficient (MAC), linear attenuation coefficient (LAC), etc were determined using Phy-X/PSD software and these parameters are increased owing to the doping of La2O3. Among all fabricated glasses, (30-x)BaCO3–30TiO2−40SiO2−6La2O3, BTS6L glass exhibited outstanding optical and radiation attenuation properties; can be tailored for the fabrication of optoelectronic and radiation protection devices.
Molecular geometry and biological activity of 2-(4-substituted-phenylimino)thiazolidin- 4-one compounds

ABSTRACT. A series of 2-(4-substituted-phenylimino)thiazolidin-4-one compounds was synthesized via heterocyclizing the corresponding N-aryl-2-chloroacetamides with ammonium thiocyanate. Their chemical structures were elucidated based on an extensive analysis of their spectroscopic data, including infrared, 1H NMR, 13C NMR, and mass analyses. The possible tautomeric forms of synthesized thiazolidine-4-ones were studied. The tautomerization equilibrium parameters, ΔH, ΔG, and Keq were calculated using the DFT/B3LYP methodology, where it has been indicated that the tautomeric form, phenylimino, is more favourable than the phenylamino form. The antibacterial and antioxidant properties of the synthesized thiazolidin-4-ones were investigated. 2-(Chlorophenyl-imino)thiazolidin-4-one displayed potent antibacterial activity against E. coli (88.46%) and S. aureus (91.66%), and highest percent of inhibition (81.8%, ABTS assay). KEY WORDS: N-aryl-2-chloroacetamides, Ammonium thiocyanate, 2-(Arylimino)thiazolidin-4-ones, Mulliken’s charges, Dipole moment, ABTS assay Bull. Chem. Soc. Ethiop. 2023, 37(5), 1275-1286. DOI: https://dx.doi. org/10.4314/bcse.v37i5. 18
Psychometric properties of the Career Adapt-Abilities Scale–Short Form: evidence from Chinese elite athletes

Objectives The present study aimed to examine the psychometric properties of the Chinese version of the Career Adapt-Abilities Scale-Short Form (CAAS-SF) among a sample of Chinese elite athletes. Methods A sample of Chinese elite athletes (n = 770) was invited to participate in this study. First, the factor structure of the Chinese version of the CAAS-SF was examined, and six measurement models (CFA, H-CFA, B-CFA, ESEM, H-ESEM, and B-ESEM) were constructed and compared. Second, the internal consistency reliability of the Chinese version of the CAAS-SF was examined. Finally, structural equation modeling (SEM) was employed to assess the nomological validity of the Chinese version of the CAAS-SF. Results The results showed that the hierarchical ESEM (H-ESEM) model best represented the factor structure of the CAAS-SF among Chinese elite athletes. It suggests that the higher-order factor of career adaptability explains the four distinctive but interrelated specific factors of concern, control, curiosity, and confidence. Cronbach's alpha coefficients (0.84–0.90), composite reliability (0.81–0.96), and coefficient omega hierarchical (0.855–0.94) of the Chinese version of the CAAS-SF were larger than the cutoff values, which suggest satisfactory reliability. The results of the SEM revealed that the higher-order factor of career adaptability was positively associated with career decision self-efficacy (β = 0.676, p < 0.001). This result is consistent with previous findings (r = 0.65, p < 0.01) and provided support for the nomological validity of the CAAS-SF among Chinese elite athletes. Conclusion The findings of the present study indicated that the Chinese version of the CAAS-SF displayed satisfactory reliability and validity and could be used to assess the career adaptability of Chinese elite athletes. In addition, the total score of the CAAS-SF is suggested to be used in future research and practical works.
The Triassic paleontology of Ghost Ranch

A hand tool apparatus uses a cutting tool with a first width and a tool axis to machine a hole in an object. The hole has a second width at least as large as the first width of the cutting tool. The tool axis passes through a predetermined point on a surface of the object. The apparatus includes an actuating assembly including a housing. The housing contains an axial feed mechanism configured for moving the cutting tool in an axial direction, a spindle motor configured for rotating the cutting tool about the tool axis, and a radial offset mechanism. The radial offset mechanism is configured for moving the axial feed mechanism in a radial direction such that the tool axis is offset from a principal axis. A motor is configured for rotating said axial feed mechanism and the cutting tool about the principal axis.