Miracle-dz/UniFAR-FTUs huggingface dataset:
Holographic multicondensate with nonlinear terms

We study the influence of nonlinear terms quartic of the charged fields, which do not change the critical points of single condensate solutions, on the phase structure of a holographic model with multi-condensate in probe limit. We include one s-wave order and one p-wave order charged under the same U(1) gauge field in the holographic model and study the influence of the three quartic nonlinear terms of the charged fields with coefficients λs, λp and λsp on the phase structure. We show the influence of each of the three parameters on the phase diagram with other two set to zero, respectively. With these nonlinear terms, we get more power on tuning the phase structure of the holographic system showing multi-condensate, and show how to get a reentrant phase transition as an example.
Supporting Cognitive and Emotional Empathic Writing of Students

We present an annotation approach to capturing emotional and cognitive empathy in student-written peer reviews on business models in German. We propose an annotation scheme that allows us to model emotional and cognitive empathy scores based on three types of review components. Also, we conducted an annotation study with three annotators based on 92 student essays to evaluate our annotation scheme. The obtained inter-rater agreement of α=0.79 for the components and the multi-π=0.41 for the empathy scores indicate that the proposed annotation scheme successfully guides annotators to a substantial to moderate agreement. Moreover, we trained predictive models to detect the annotated empathy structures and embedded them in an adaptive writing support system for students to receive individual empathy feedback independent of an instructor, time, and location. We evaluated our tool in a peer learning exercise with 58 students and found promising results for perceived empathy skill learning, perceived feedback accuracy, and intention to use. Finally, we present our freely available corpus of 500 empathy-annotated, student-written peer reviews on business models and our annotation guidelines to encourage future research on the design and development of empathy support systems.
Structure and bonding of water molecules in zeolite hosts: Benchmarking plane-wave DFT against crystal structure data

Abstract Density-functional theory (DFT) calculations are widely employed to study the interaction of water molecules with zeolite frameworks. However, there have been only few attempts to assess whether these computations reproduce experimental structure data sufficiently well, especially with regard to the hydrogen positions of the water molecules. In this work, a detailed comparison between experimental crystal structures and DFT-optimised structures is made for six water-loaded natural zeolites. For each system, high-quality structure determinations from neutron diffraction data have been reported (bikitaite/Li–BIK, edingtonite/Ba–EDI, gismondine/Ca–GIS, scolecite/Ca–NAT, natrolite/Na–NAT, yugawaralite/Ca–YUG). Using a plane-wave DFT approach, the performance of six pure and three dispersion-corrected exchange-correlation functionals is compared, focusing on an optimisation of the atomic coordinates in a fixed unit cell (with cell parameters taken from experiment). It is found that the PBE and the PW91 functional give the smallest overall deviation between experiment and computation. Of the dispersion-corrected approaches, the PBE–TS functional exhibits the best performance. For the PBE and PBE–TS functionals, the agreement between experiment and DFT is analysed in more detail for different groups of interatomic distances. Regarding the OW–H distances in the water molecules, the DFT optimisations lead to physically realistic bond lengths. On the other hand, DFT has a systematic tendency to underestimate the length of hydrogen bonds. The cation-oxygen distances are mostly in very good agreement with experiment, although some exceptions indicate the necessity of further studies.
Resultant-based Elimination in Ore Algebra

We consider resultant-based methods for elimination of indeterminates of Ore polynomial systems in Ore algebra. We start with deﬁning the concept of resultant for bivariate Ore polynomials then compute it by the Dieudonn´e determinant of the polynomial coeﬃcients. Additionally, we apply noncommutative versions of evaluation and interpolation techniques to the computation process to improve the eﬃciency of the method. The implementation of the algorithms will be performed in Maple to evaluate the performance of the approaches.
Riemannian geometry for restricted positive semidefinite matrices

We introduce the manifold of restricted n×n positive semidefinite matrices of fixed rank p, denoted S (n, p)∗. The manifold itself is an open and dense submanifold of S (n, p), the manifold of n × n positive semidefinite matrices of the same rank p, when both are viewed as manifolds in Rn×n. This density is the key fact that makes the consideration of S (n, p)∗ statistically meaningful. We furnish S (n, p)∗ with a convenient, and geodesically complete, Riemannian geometry, as well as a Lie group structure, that permits analytical closed forms for endpoint geodesics, parallel transports, Fréchet means, exponential and logarithmic maps. This task is done partly through utilizing a reduced Cholesky decomposition, whose algorithm is also provided. We produce a second algorithm from this framework to estimate principal eigenspaces and demonstrate its superior performance over other existing algorithms.
Association of ERα-36 expression with the de novo resistance of tamoxifen in ER-positive breast cancer.

BACKGROUND Approximately 70-80% of breast cancer express ER-alpha and hormonal therapies, given significant improvements in patient survival. About 50% of ER-positive breast cancer patients with advanced disease insensitive to tamoxifen treatment when diagnosed. Recent studies have shown that ERα-36 is a crucial factor in the resistance of tamoxifen. OBJECTIVE This study aims to determine the association between ERα-36 expression and de novo resistance of tamoxifen in patients with ER-positive breast cancer. METHODS This study was an observational study using a cross-sectional method and was conducted at Wahidin Sudirohusodo Hospital and Unhas Hospital. ERα-36 protein expression was assessed using an immunohistochemistry assay. The association of ERα-36 expression and resistance of tamoxifen was tested with the Chi-square test. RESULTS A total of 50 locally advanced breast cancer cases were included in this study, 22 cases (44%) had overexpression of ERα-36, and 28 cases (56%) had not, 24 cases (48%) had experience resistance to tamoxifen and 26 cases (52%) had not. There was a significant association between ERα-36 expressions and resistance of tamoxifen (p = 0.000). CONCLUSIONS There was an association between the expression of ER-α36 with de novo resistance of tamoxifen in ER-positive breast cancer. ER-α36 could act as a worth considering biomarker for de novo resistance of tamoxifen in therapeutic strategies.
Aligning Health Care and Social Services to Reduce Hospitalizations and Emergency Department Visits

Background: Integration of social services in health care delivery is increasingly recognized as a potential strategy for improving health and reducing the use of acute care services. Collaborative models that provide older adults with case management, linkages to social services, and assistance with health care navigation have emerged as promising strategies. Objective: The objective of this study was to evaluate the Community Care Connections (CCC) program, a cross-sector collaboration designed to align social and health care services for older adults. Research Design: We compared hospitalizations and emergency department (ED) visits 90 days after enrollment with a propensity score–matched group of non-CCC patients. Subgroup analyses were also conducted for adults with hypertension, diabetes, and high cholesterol. Subjects: A total of 1004 patients enrolled in CCC between June 1, 2016, and November 15, 2018, and 1004 matched patients from the same metropolitan area. Measures: Mean hospitalizations and ED visits per patient 90 days after CCC enrollment. Results: Mean hospitalizations were lower among CCC patients 90 days after enrollment than among non-CCC adults [difference=−0.039, 95% confidence interval (CI): −0.077 to −0.001, P=0.044]. They were also lower among CCC patients with hypertension (difference=−0.057, 95% CI: −0.103 to −0.010, P=0.017). However, 90 days after enrollment mean ED visits were higher among CCC patients relative to non-CCC adults (difference=0.238, 95% CI: 0.195–0.281, P<0.001). Conclusions: Connecting older adults to social services while being served by the health care system may lead to decreases in hospitalizations. Cross-sector partnerships that address social and economic needs may reduce the use of costly health care services.
Reduction of endotoxicity in Bordetella bronchiseptica by lipid A engineering: Characterization of lpxL1 and pagP mutants

ABSTRACT Whole-cell vaccines against Gram-negative bacteria commonly display high reactogenicity caused by the endotoxic activity of lipopolysaccharide (LPS), one of the major components of the bacterial outer membrane. Underacylation of the lipid A moiety of LPS has been related with reduced endotoxicity in several Gram-negative species. Here, we evaluated whether the inactivation of two genes encoding lipid A acylases of Bordetella bronchiseptica, i.e. pagP and lpxL1, could be used for the development of less reactogenic vaccines against this pathogen for livestock and companion animals. Inactivation of pagP resulted in the loss of the secondary palmitate chain at position 3' of lipid A, but hardly affected the potency of the LPS to activate the Toll-like receptor 4 (TLR4). Inactivation of lpxL1 resulted in the loss of the secondary 2-hydroxy laurate group present at position 2 of lipid A and, unexpectedly, in the additional loss of the glucosamines that decorate the phosphate groups at positions 1 and 4' and in an increase in LPS molecules carrying O-antigen. The resulting LPS showed greatly reduced potency to activate TLR4 in HEK-Blue reporter cells expressing human or mouse TLR4 as well as in porcine macrophages. Characterization of the lpxL1 mutant revealed many pleiotropic phenotypes, including increased resistance to SDS and rifampicin, increased susceptibility to cationic antimicrobial peptides, decreased auto-aggregation and biofilm formation, and a tendency to decreased infectivity of macrophages, which are all related to the altered LPS structure. We suggest that the lpxL1 mutant will be useful for the generation of safer vaccines.
Adverse perioperative outcomes among patients undergoing gastrointestinal cancer surgery: Quantifying attributable risk from malnutrition.

BACKGROUND Preoperative malnutrition adversely impacts perioperative outcomes among patients with gastrointestinal (GI) cancer. The attributable risk (AR) that nutrition status contributes towards negative outcomes is poorly understood. DESIGN Adults undergoing GI cancer surgeries were identified within the ACS-NSQIP database (2005-2017). Emergency surgeries, outpatients, and cases with an ASA status >III were excluded. Adjusted multivariable models were constructed to determine the associations between markers of nutrition status (BMI, >10% weight loss in last 6-months, functional status, and albumin) and adverse perioperative outcomes (presence and number of complications, death, 30-day readmission, and length of stay). Predictive accuracy statistics and population attributable risk (PAR) were determined. RESULTS The final sample included 78,662 cases. Patients with greater than 10% weight loss six months preceding surgery (compared to those who did not), had a significantly increased risk of complications (RR = 1.28, 95% CI 1.20,1.37) and odds of death (OR = 1.37, 95% CI 1.18,1.59). A totally dependent functional status (compared to independent status) was associated with a 3.3 times higher odds of death (OR = 3.30, 95% CI 1.53,7.15). Multivariable models were not predictive of adverse outcomes; the PAR from the markers ranged 1-2%. CONCLUSIONS Ten-percent weight loss in preceding 6-months was associated with increased risk of adverse perioperative outcomes among adults undergoing GI cancer surgery. The contribution of nutrition status markers to surgical outcomes as assessed by PAR was small (1-2%), a finding not previously reported. Future intervention studies should include validated nutrition risk markers, control for effects of perioperative variables, and evaluate PAR within the immediate/long-term postoperative periods. This article is protected by copyright. All rights reserved.
Comparison of RNA‐ and DNA‐based methods for measurable residual disease analysis in NPM1‐mutated acute myeloid leukemia

Reverse transcriptase quantitative PCR (RT‐qPCR) is considered the method of choice for measurable residual disease (MRD) assessment in NPM1‐mutated acute myeloid leukemia (AML). MRD can also be determined with DNA‐based methods offering certain advantages. We here compared the DNA‐based methods quantitative PCR (qPCR), droplet digital PCR (ddPCR), and targeted deep sequencing (deep seq) with RT‐qPCR.
The Role of NLRP3 Inflammasome in Cerebrovascular Diseases Pathology and Possible Therapeutic Targets

Cerebrovascular diseases are pathological conditions involving impaired blood flow in the brain, primarily including ischaemic stroke, intracranial haemorrhage, and subarachnoid haemorrhage. The nucleotide-binding and oligomerisation (NOD) domain-like receptor (NLR) family pyrin domain (PYD)-containing 3 (NLRP3) inflammasome is a protein complex and a vital component of the immune system. Emerging evidence has indicated that the NLRP3 inflammasome plays an important role in cerebrovascular diseases. The function of the NLRP3 inflammasome in the pathogenesis of cerebrovascular diseases remains an interesting field of research. In this review, we first summarised the pathological mechanism of cerebrovascular diseases and the pathological mechanism of the NLRP3 inflammasome in aggravating atherosclerosis and cerebrovascular diseases. Second, we outlined signalling pathways through which the NLRP3 inflammasome participates in aggravating or mitigating cerebrovascular diseases. Reactive oxygen species (ROS)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), ROS/thioredoxin-interacting protein (TXNIP) and purinergic receptor-7 (P2X7R) signalling pathways can activate the NLRP3 inflammasome; activation of the NLRP3 inflammasome can aggravate cerebrovascular diseases by mediating apoptosis and pyroptosis. Autophagy/mitochondrial autophagy, nuclear factor E2-related factor-2 (Nrf2), interferon (IFN)-β, sirtuin (SIRT), and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) reportedly alleviate cerebrovascular diseases by inhibiting NLRP3 inflammasome activation. Finally, we explored specific inhibitors of the NLRP3 inflammasome based on the two-step activation of the NLRP3 inflammasome, which can be developed as new drugs to treat cerebrovascular diseases.
A retrospective case‐control cohort analysis of comorbidity and health expenditure in hospitalized adults diagnosed with obesity utilizing ICD‐10 diagnostic coding

The cost and comorbidity of obesity in hospitalized inpatients, is less known. A retrospective study of patients presenting to a large district hospital in Western Sydney (April 2016‐February 2017) using clinical, pathological as well as diagnostic coding data for obesity as per ICD‐10. Of 43 212 consecutive hospital presentations, 390 had an obesity‐coded diagnosis (Ob, 0.90%), of which 244 were gender and age‐matched to a non‐obesity coded cohort (NOb). Weight and BMI were higher in the Ob vs NOb group (126 ± 37 vs 82 ± 25 kg; BMI 46 ± 12 vs 29 ± 8 kg/m2, P < .001) with a medical record documentation rate of 62% for obesity among Ob. The Ob cohort had 2‐5× higher rates of cardiopulmonary and metabolic complications (P < .001), greater pharmacologic burden, length of stay (LOS, 225 vs 89 hours, P < .001) and stay in intensive care but no differences in the prevalence of mental disorders. Compared with BMI <35 kg/m2, inpatients with BMI >35 kg/m2 were 5× more likely to require intensive care (OR 5.08 [1.43‐27.3, 95% CI], P = .0047). The initiation of obesity‐specific interventions by clinical teams was very low. People with obesity who are admitted to hospital carry significant cost and complications, yet obesity is seldom recognized as a clinical entity or contributor.
Public sensemaking of active packaging technologies: A feature-based perspective

Taking a point of departure in the idea that technology features can act as cues for sensemaking, we explore how the public makes sense of new active packaging technologies; technologies that absorb or release substances from or into the packaging atmosphere, preserving the freshness and safety of food products. Based on data from ten focus groups across five countries (Ireland, Denmark, Italy, Spain and China), we show that sensemaking occurs at two feature-proximity levels. At the first level, we observe the production of proximal representations, where salient technology features drive the sensemaking process and how the individuals come to understand the essence of the technology. At the second level, we observe the production of distal representations, where distinct technology features become less salient, and the holistic understanding of the technology takes over in how individuals come to understand the locus of the technology in broader contexts. Our insights contribute to theory regarding public sensemaking of novel technologies and have practical implications for stakeholders who aim to increase their adoption prospects.
Anti-lipopolysaccharide antibody mitigates ruminal lipopolysaccharide release without acute-phase inflammation or liver transcriptomic responses in Holstein bulls

Anti-lipopolysaccharide (LPS) antibody administration has the potential benefits of neutralizing and consequently controlling rumen-derived LPS during subacute ruminal acidosis. Four Holstein bulls were used in this crossover study with a 2-week wash-out period. Anti-LPS antibody (0 or 4 g) was administered once daily for 14 days. Significantly lower ruminal LPS and higher 1-h mean ruminal pH were identified in the 4 g group. However, blood metabolites, acute-phase proteins, cytokines, and hepatic transcriptomes were not different between the two groups. Therefore, anti-LPS antibody administration mitigated ruminal LPS release and pH depression without accompanying responses in acute-phase inflammation or hepatic transcriptomic expression.
Current Trends in Facial Feminization Surgery: An Assessment of Safety and Style

Background: Facial feminization surgery (FFS) plays an instrumental role in the process of gender affirmation. These procedures are becoming increasingly appreciated for their ability to improve patient satisfaction and gender identity in a way that alleviates gender dysphoria and improves the quality of life. Despite the recent surge in popularity across the US, the current literature lacks evidence on the safety profile of combined facial feminization procedures. Our goal was to determine the safety profile of facial feminization procedures registered on a national surgical database. Methods: Patients with a primary diagnosis of gender dysphoria undergoing facial surgical procedures were identified from the National Surgical Quality Improvement Program database between the years 2013 and 2018. Demographic characteristics along with 30-day postoperative complications were recorded. Logistic regression models adjusted for confounders were used to determine the independent predictors of postoperative complications. Results: A cohort of 77 patients who underwent a total of 220 procedures was identified. The number of patients undergoing surgery per year increased from three (3.9%) in 2013 to 41 (53.2%) in 2018, a 13.6-fold increase. The most commonly performed procedure was forehead contouring/frontal sinus setback, performed on 52 patients (67.5%), followed by orbital contouring (n = 37, 48%), rhinoplasty (n = 34, 44%), mandibuloplasty (n = 34, 44%), chondrolaryngoplasty (n = 27, 35.1%), genioplasty (n = 11, 14%), brow lift (n = 9, 11.7%), cheek augmentation (n = 9, 11.7%), and lip lift (n = 7, 9.1%). The number of patients who underwent 5 or more procedures in a single anesthetic event was 41 (53.2%). The complication rate was 3.9%. Univariate analysis suggested an association between older age and postoperative morbidity (P < 0.02). However, this was not found to be an independent predictor on multivariate analysis adjusted for confounders (P < 0.083). Additionally, an increase in operative time and the number of procedures performed during a single anesthetic were not independent predictors of 30-day postoperative complications (P < 0.317 and P < 0.19, respectively). Conclusions: FFS can be safely performed and has a low risk of postoperative morbidity. The number of patients seeking FFS surgery has risen exponentially, with the highest demand seen for the reconstruction of the upper facial third. These findings should guide expectations for patients seeking FFS, as well as for plastic surgeons looking to perform multiple procedures per anesthetic event.
Evaluating the Intra-Rater and Inter-Rater Reliability of Fixed Tension Scale Instrumentation for Determining Isometric Neck Strength.

PURPOSE The purpose of this study was to evaluate the reliability of a fixed tension scale instrumentation, comparing the intra-rater and inter-rater reliability between seating and standing measurement techniques. Instrumentation developed from this study will be utilized to assess isometric neck strength in future studies comparing neck strengthening protocols. METHODS Isometric neck strength for eight movements (cervical/capital flexion, cervical/capital extension, left/right lateral flexion, left/right cervical rotation) as well as anthropometric measurements were evaluated for thirty-one participants through the use of a novel neck strength assessment protocol. RESULTS The fixed tension scale instrumentation and methods used in this study demonstrated good to excellent intra-rater reliability (ICC range from 0.78 to 0.97) as well as moderate to excellent inter-rater reliability (ICC range from 0.73 to 0.91) for both measurement techniques. PRACTICAL APPLICATIONS This study will provide foundational knowledge for the reliable assessment of neck strength. Additionally, the findings will provide a cost-effective, portable, and reliable instrument for measuring isometric neck strength. CONCLUSIONS Seated and standing measurement techniques demonstrated similar intra and inter-rater reliability. Inter-rater reliability tended to be lower with motions (capital flexion and extension) that required the participants to face directly towards or away from the instrumentation. This could be due to participant positioning or unfamiliarity with those specific movements. The assessment protocol utilized in this study demonstrated comparable inter-rater reliability to another cost-effective method for evaluating isometric neck strength.