Miracle-dz/UniFAR-FTUs huggingface dataset:
Human ApoA-I1 Inhibits the Hydrolysis of HDL Triglyceride and the Decrease of HDL Size Induced by Hypertriglyceridemia and Cholesteryl Ester Transfer Protein in Transgenic Mice

The plasma cholesteryl ester transfer protein (CETP) mediates the exchange of HDL cholesteryl esters with triglycerides of other lipoproteins. Subsequent lipolysis of the triglyceride-enriched HDL by hepatic lipase leads to reductions of HDL size and apoA-I content. To investigate a possible modulation of the effects of CETP by apoA-II, human CETP transgenic mice were cross-bred with transgenic mice expressing human apoA-II and, in some cases, human apoAI and apoC-III (with human-like HDL and hypertriglyceridemia). CETP expression resulted in reductions of HDL and increases in VLDL cholesteryl ester in mice expressing human apoA-II, alone or in combination with apoA-I and apoC-III, indicating that apoA-II does not inhibit the cholesteryl ester transfer activity of CETP. However, CETP expression resulted in more prominent increases in HDL triglyceride in mice expressing both apoA-II and CETP, especially in CETP/apoA-II/apoAl-CIII transgenic mice. CETP expression caused dramatic reductions in HDL size and apoA-I content in apoAl-CIII transgenic mice, but not in apoA-II/AI-CHI transgenic mice. HDL prepared from mice of various genotypes showed inhibition of emulsionbased hepatic lipase activity in proportion to the apoA-II/ apoA-I ratio of HDL. The presence of human apoA-II also inhibited mouse plasma hepatic lipase activity on HDL triglyceride. Thus, apoA-II does not inhibit the lipid transfer activity of CETP in vivo. However, coexpression of apoAII with CETP results in HDL particles that are more triglyceride enriched and resistant to reductions in size and apoAI content, reflecting inhibition of hepatic lipase by apoA-II. The inhibition ofHDL remodeling by apoA-II could explain the relatively constant levels ofHDL containing both apoAI and apoA-ll in human populations. (J. Clin. Invest. 1994. 94:2457-2467.)
COMPREHENSIVE INVITED REVIEW A Critical Update of the Assessment and Acute Management of Patients with Severe Burns

Thomas Charles Lang,* Ruilong Zhao, Albert Kim, Aruna Wijewardena, John Vandervord, Meilang Xue, and Christopher John Jackson Department of Anesthesia, Prince of Wales and Sydney Children’s Hospitals, Randwick, Australia. Sutton Laboratories, The Kolling Institute, St. Leonards, Australia. Departments of Critical Care Medicine and Burns, Reconstructive and Plastic Surgery, Royal North Shore Hospital, St. Leonards, Australia.
Actin Binding to Lipid-inserted a-Actinin

The interaction of a-actinin with lipid films and actin filaments was investigated. First a-actinin was incorporated in lipid films at the air/water interface. Injection of a-actinin into the subphase of a lipid monolayer led to a significant increase of the surface pressure only for lipid films consisting of a mixture of a negatively charged lipid with a high proportion of diacylglycerol. These a-actinin-containing films were transferred onto silanized quartz slides. Photobleaching experiments in the evanescent field allowed quantification of the lateral number density of the lipid-bound a-actinin. In combination with the area increase from the monolayer experiments, the photobleaching measurements suggest that a-actinin is incorporated into the lipid film in such a way that actin binding sites are accessible from the bulk phase. Binding experiments confirmed that the a-actinin selectively binds actin filaments in this configuration. We also showed that, in contrast to actin filaments which are adsorbed directly onto planar surfaces, the a-actinin-bound actin filaments are recognized and cleaved by the actin-severing protein gelsolin. Thus we have constructed an in vitro system which opens new ways for investigations of membrane-associated actin-binding proteins and of the physical behavior of actin filaments in the close neighborhood to membranes.
„I just ran two million regressions”, avagy módszertani paradigmák a kvantitatív társadalomkutatásban

Kuhn ota elfogadott nezet, hogy a kulonboző korok paradigmatikus elmeletei nem csak tartalmilag, hanem modszertanilag is kulonboznek egymastol. Ennek ellenere a modszert alkalmazo tudomany (előadasomban: a kvantitativ tarsadalomkutatas) vagy maguk a modszerek (előadasomban: a statisztikai eszkozok) ritkan reflektalnak erre. Hasonloan ritkan merul fel az a szempont, hogy maganak a statisztikanak is onallo, a tarsadalomtudomanyoktol reszben fuggetlen tortenete van, sajat paradigmakkal, melyek talan az altala szolgalt tudomanyra, annak szemleletere, fogalmaira, kerdesfelteveseire is hatast gyakorolnak. Előadasomban nehany peldaval igyekszem alatamasztani ezt az allaspontomat.
Autonomous quantum error correction with superconducting qubits

In this thesis, we develop several tools in the direction of autonomous Quantum Error Correction (QEC) with superconducting qubits. We design an autonomous QEC scheme based on quantum reservoir engineering, in which transmon qubits are coupled to lossy modes. Through an engineered interaction between these systems, the entropy created by eventual errors is evacuated via the dissipative modes.The second part of this work focus on the recently developed cat codes, through which the logical information is encoded in the large Hilbert space of a harmonic oscillator. We propose a scheme to perform continuous and quantum non-demolition measurements of photon-number parity in a microwave cavity, which corresponds to the error syndrome in the cat code. In our design, we exploit the strongly nonlinear Hamiltonian of a highimpedance Josephson circuit, coupling ahigh-Q cavity storage cavity mode to a low-Q readout one. Last, as a follow up of the above results, we present several continuous and/or autonomous QEC schemes using the cat code. These schemes provide a robust protection against dominant error channels in the presence of multi-photon driven dissipation.
Specificity and Evolution of Post-translational Biotin Addition

Biotin, which serves as a carboxyl group carrier in reactions catalyzed by carboxylases, is essential for life in most organisms. In order to function in carboxylate transfer the vitamin must first be post-translationally linked to a specific lysine residue on the biotin carboxyl carrier of a biotindependent carboxylase in a reaction catalyzed by biotin protein ligases. Although the biotin addition is highly selective for any single carboxylase substrate, previous observations of interspecies biotinylation suggested little discrimination among the biotin carboxyl carriers derived from the carboxylases of a broad range of organisms. Application of single turnover kinetic techniques to measurements of post-translational biotin addition reveals previously unappreciated selectivity that may be of physiological significance. Biotin: A Brief Overview and History Biotin, vitamin B7 or vitamin H, is an essential nutrient that is required by most organisms for viability[1]. It functions as a coenzyme in carboxylation [2] reactions that contribute to important mammalian metabolic processes including fatty acid biosynthesis and breakdown, amino acid catabolism and gluconeogenesis. The mammalian biotin-dependent carboxylases include acetyl-CoA carboxylase, propionyl-CoA carboxylase, pyruvate carboxylase and methyl-crotonyl CoA carboxylase. Loss of function of any of these enzymes has serious consequences for human health[3–5]. Biotin was first identified from studies of the toxic effects of feeding raw egg whites, which contain avidin, to rats. These effects, which included skin lesions, alopecia, and loss of muscle coordination, could be reversed by protective factor X, a heat stable factor from yeast or liver [6]. In 1927 M.A. Boas showed that animals required factor X, which also referred to as vitamin H [6]. György et al. demonstrated that vitamin H and biotin were the same compound[7]. The structure of biotin was determined in 1942 (Figure 1, [8]). Biotin-Dependent Carboxylases Biotin-dependent carboxylases are complex machines that contain a minimum of three activities including a biotin carboxyl carrier (BCC), a biotin carboxylase (BC) and a carboxyl transferase (CT) (Figure 2A,[9]). The biotin coenzyme is linked to a specific lysine residue on the BCC moiety of the enzyme. In some biotin-dependent carboxylases all three activities are encoded in a single polypeptide chain. In others, typically from prokaryotes, dbeckett@umd.edu. HHS Public Access Author manuscript Biochem Soc Trans. Author manuscript; available in PMC 2020 November 30. Published in final edited form as: Biochem Soc Trans. 2018 December 17; 46(6): 1577–1591. doi:10.1042/BST20180425. A uhor M anscript
Ion channels and arteriolar tone: Ion channels and the regulation ofmyogenic tone in peripheral arterioles

Myogenic tone is a hall-mark feature of arterioles in the microcirculation. This pressure-induced, contractile activation of vascular smooth muscle cells (VSMCs) in the wall of these microvessels importantly contributes to the regulation and maintenance of blood pressure; blood flow to and within organs and tissues; and capillary pressure and fluid balance. Ion channels play a central role in the genesis and maintenance of myogenic tone. Mechanosensitive ion channels such as TRPC6 may serve as one of the sensors of pressure-induced membrane stress/strain, and TRPC6 along with TRPM4 channels are responsible for pressure-induced VSMC depolarization that may be bolstered by the activity of Ca2+-activated Cl− channels and inhibition of voltage-gated K+ (KV) channels, inwardly-rectifying K+ (KIR) channels and ATP-sensitive K+ (KATP) channels. Membrane potential depolarization activates voltage-gated Ca2+ channels (VGCCs), with CaV1.2 channels playing a central role. Calcium entry through CaV1.2 channels, which is amplified by Ca2+ release through IP3 receptors in the form of Ca2+ waves in some arterioles, provides the major source of activator calcium responsible for arteriolar myogenic tone. Stabilizing negative-feedback comes from depolarizationand Ca2+-induced activation of large-conductance Ca2+-activated K+ channels and depolarization-induced activation of KV channels. Myogenic tone also is dampened by tonic activity of KIR and KATP channels. While much has been learned about ion channel expression and function in myogenic tone, additional studies are required to fill in our knowledge gaps due to significant regional differences in ion channel expression and function and a lack of data specifically from VSMCs in arterioles.
Inspection Time and ADHD Symptoms in Children with Cerebral Palsy

Objective—To examine between-group differences in the associations between aspects of processing speed assessed with an inspection time task, and attention-deficit/hyperactivity disorder (ADHD) symptoms. Research Design—Two groups comprised of 34 children with cerebral palsy (CP) and 70 nonaffected peers (Control), ages 8 – 16, participated in a prospective correlational study. Measures included a visual inspection time task and the Conners’ Parent Rating Scale – Revised: Long Version. Results—Children with CP exhibited significantly slower processing speed, and more symptoms of inattention and hyperactivity than Controls. Significant associations between inspection time and ADHD symptoms were found only in the Control group. Conclusions—Findings have implications for clinical assessment and understanding of attentional risks associated with CP.
Systemic Lupus Erythematosus Is Associated With Increased Prevalence of Atherosclerotic Cardiovascular Disease in Hospitalized Patients

Objectives: To assess the prevalence of atherosclerotic cardiovascular disease (ASCVD) and its individual phenotypes of coronary artery disease (CAD), peripheral artery disease (PAD), and cerebrovascular disease (CVD) by age and sex in a large cohort of patients with SLE hospitalized in the United States. Methods: A nested case-control study of adults with and without SLE was conducted from the January 1, 2008-December 31, 2014 National Inpatient Sample. Patients hospitalized with a diagnosis of SLE were matched (1:3) by age, sex, race, and calendar year to patients hospitalized without a diagnosis of SLE. The prevalence of CAD, PAD, and CVD were evaluated and associations with SLE were determined after adjustment for common cardiovascular risk factors. Results: Among the 252,676 patients with SLE and 758,034 matched patients without SLE, the mean age was 51, 89% were women, and 49% were white. Patients with SLE had a higher prevalence of ASCVD compared to those without SLE (25.6% vs. 19.2%; OR 1.45, 95% CI 1.44 to 1.47, P<.001). After multivariable adjustment, SLE was associated with a greater odds of ASCVD (aOR 1.46, 95% CI 1.41–1.51). The association between SLE and ASCVD was observed in women and men and was attenuated with increasing age. SLE was also associated with increased odds of CAD (aOR 1.42, 95% CI 1.40–1.44), PAD (aOR 1.25, 95% CI 1.22–1.28), and CVD (aOR 1.68, 95% CI 1.65–1.71). Corresponding author: Jeffrey S. Berger, MD, MS, Associate Professor of Medicine and Surgery, Co-Director, Center for the Prevention of Cardiovascular Disease, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, 530 First Avenue, Skirball 9R, New York, NY 10016, Tel. 212-263-4004; Fax. 212-263-3988, jeffrey.berger@nyumc.org. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. HHS Public Access Author manuscript Mayo Clin Proc. Author manuscript; available in PMC 2020 August 01. Published in final edited form as: Mayo Clin Proc. 2019 August ; 94(8): 1436–1443. doi:10.1016/j.mayocp. 2019.01. 044. A uhor M anscript
Azteca instabilis: First Report of the Ant in the Tropical Dry Forest at Tamaulipas, Mexico

Abstract. The arboreal ant Azteca instabilis (F. Smith 1862) was found in flowers of the epiphytic bromeliad Tillandsia baileyi (Rose ex Small) at a tropical dry forest. This is the first report of A. instabilis at Tamaulipas, expanding its distribution in the northern neotropics. The knowledge is important for further establishment of conservation strategies for ants and epiphytes.
Assessment of Insecticide Expenditure and Thrips Targeted Management Expense in Dry Bulb Onion Crops in Idaho, Oregon, and Washington

Abstract. Data from the 2020 USDA chemical use survey for onions, Allium cepa L. , were combined with survey data collected at industry meetings to estimate expenditure for commonly applied active ingredients used to manage insect pests of dry bulb onions produced in the Pacific Northwest states of Idaho, Oregon, and Washington. The portion of insecticide expenditure used to manage thrips, Thrips tabaci (Lindeman), was also estimated. Total expenditure to manage insect pests was estimated to be 13.8 million US dollars. Approximately 82% of total insecticide expenditure, 11.4 million US dollars, was used to manage thrips.
Robust online voltage control with an unknown grid topology

Voltage control generally requires accurate information about the grid's topology in order to guarantee network stability. However, accurate topology identification is a challenging problem for existing methods, especially as the grid is subject to increasingly frequent reconfiguration due to the adoption of renewable energy. Further, running existing control mechanisms with incorrect network information may lead to unstable control. In this work, we combine a nested convex body chasing algorithm with a robust predictive controller to achieve provably finite-time convergence to safe voltage limits in the online setting where the network topology is initially unknown. Specifically, the online controller does not know the true network topology and line parameters, but instead must learn them over time by narrowing down the set of network topologies and line parameters that are consistent with its observations and adjusting reactive power generation accordingly to keep voltages within desired safety limits. We demonstrate the effectiveness of the approach using a case study, which shows that in practical settings the controller is indeed able to narrow the set of consistent topologies quickly enough to make control decisions that ensure stability.
Evaluation of the Performance of an Immersive System for Tele-education

Tele-education was already a solution for people who cannot attend lessons in person (such as inaccessibility in rural areas or illness issues). However, COVID has revealed problems in tele-education with current technology, causing adolescents and children to slow down their learning curves and experience problems of social distancing with their classmates. This paper presents a user study to validate an immersive communication system for tele-education purposes. This system streams in real time a class using 360-degree cameras, allowing remote students to explore the whole scene and improving the feeling of being in the classroom with their colleagues. Additionally, the prototype provides notifications to the remote students about events (such as a changes in the teacher’s presentation or classmates raising their hands) that occur outside their viewport to indicate in which direction they should move their heads to visualize them. To validate the system and investigate its possible added value, socioemotional factors such as presence, perceived quality, usability, and usefulness of the notifications were evaluated through a user test using questionnaires. The obtained results show that using immersive tele-education systems can improve the presence, as well as the benefits of the notifications on the experience of the remote students.
An Exploration of Account Sharing Practices on Media Platforms

Often accounts and profiles on media platforms discount the real-world complexities of sharing by naively designing technology that supports one user per account. While recently popular media platforms like Netlfix and Disney+ have started responding here, the solutions are simplistic. Within research, despite recent interest, a holistic narrative of the practicalities of sharing and support which could be effectively leveraged for future design of media platforms that support sharing is yet to be investigated. This paper reports a set of user focus groups and expert interviews that present a holistic set of 5 challenges confronting this scope. We further situate these findings in two practical examples of sharing, one current and one near-future, to demonstrate the real-world applicability of said findings by both explicating the challenges and using them as a lens to start exploring responses in each case.
DE‐SLAM: SLAM for highly dynamic environment

Simultaneous localization and mapping (SLAM) is crucial for autonomous mobile robots. Most of the current SLAM systems are based on an assumption: the environment is static. However, the real environment is full of dynamic elements, such as pedestrians or vehicles, as well as changes in illumination and appearance over time. In this paper, DE‐SLAM, a visual SLAM system that can deal with short‐term and long‐term dynamic elements at the same time is proposed. A novel dynamic detection and tracking module that utilizes both semantic and metric information is proposed, and the localization accuracy is highly improved by eliminating features falling on the dynamic objects. A unified loop detection, loop check and global optimization module is used to perform loop closure. Experimental results on datasets and real environments show that DE‐SLAM outperforms other state‐of‐the‐art SLAM systems in dynamic environments.
Using the Health and Retirement Study for Research on the Impact of the Working Conditions on the Individual Life Course

Abstract The aim of this paper is to evaluate the utility of the Health and Retirement Study (HRS) for studying the impact of working conditions on individuals’ health, well-being and labor supply decisions at older ages. I provide a brief overview of the information on working conditions that is currently available in the HRS and discuss implications for studies on the effects of working conditions on the individual life course. I conclude with a discussion of how recent and projected trends in the U.S. workforce are reflected in the current HRS survey content.
Therapeutic goal of diabetes mellitus

Madam, The recent report by Lahiri et al., on therapeutic goal of diabetes mellitus is very interesting. [1] Lahiri et al., found that “Knowledge of diabetes was significantly high among higher educated; poor among women, house-wives, and rural people. ’’[1] We agree with this conclusion. However, some issues on this work should be mentioned. The important problem is the definition of good control of glucose homeostasis among the subjects. There is no clear definitive definition in this work. The authors referred to blood glucose in this work which might not be acceptable in laboratory medicine. Indeed, the good clinical chemistry parameter to determine the control of blood glucose in diabetic patients should be hemoglobin A1C or fructosamine.
Characterization of enhanced interferometric gravitational-wave detectors and studies of numeric simulations for compact-binary coalescences

Gravitational waves are a consequence of the general theory of relativity. Direct detection of such waves will provide a wealth of information about physics, astronomy, and cosmology. A worldwide effort is currently underway to make the first direct detection of gravitational waves. The global network of detectors includes the Laser Interferometer Gravitational-wave Observatory (LIGO), which recently completed its sixth science run. A particularly promising source of gravitational waves is a binary system consisting of two neutron stars and/or black holes. As the objects orbit each other they emit gravitational radiation, lose energy, and spiral inwards. This produces a characteristic “chirp” signal for which we can search in the LIGO data. Currently this is done using matched-filter techniques, which correlate the detector data against analytic models of the emitted gravitational waves. Several choices must be made in constructing a search for signals from such binary coalescences. Any discrepancy between the signals and the models used will reduce the effectiveness of the matched filter. However, the analytic models are based on approximations which are not valid through the entire evolution of the binary. In recent years numerical relativity has had impressive success in simulating the final phases of the coalescence of binary black holes. While numerical relativity is too computationally expensive to use directly in the search, this progress has made it possible to perform realistic tests of the LIGO searches. The results of such tests can be used to improve the efficiency of searches. Conversely, noise in the LIGO and Virgo detectors can reduce the efficiency. This must be addressed by characterizing the quality of the data from the detectors, and removing from the analysis times that will be detrimental to the search. In this thesis we utilize recent results from numerical relativity to study both the degree to which analytic models match realistic waveforms and the ability of LIGO searches to make detections. We also apply the matched-filter search to the problem of removing times of excess noise from the search.