Miracle-dz/UniFAR-FTUs huggingface dataset:
Cultured Myoblasts Derived from Rat Soleus Muscle Show Altered Regulation of Proliferation and Myogenesis during the Course of Mechanical Unloading

The structure and function of soleus muscle fibers undergo substantial remodeling under real or simulated microgravity conditions. However, unloading-induced changes in the functional activity of skeletal muscle primary myoblasts remain poorly studied. The purpose of our study was to investigate how short-term and long-term mechanical unloading would affect cultured myoblasts derived from rat soleus muscle. Mechanical unloading was simulated by rat hindlimb suspension model (HS). Myoblasts were purified from rat soleus at basal conditions and after 1, 3, 7, and 14 days of HS. Myoblasts were expanded in vitro, and the myogenic nature was confirmed by their ability to differentiate as well as by immunostaining/mRNA expression of myogenic markers. The proliferation activity at different time points after HS was analyzed, and transcriptome analysis was performed. We have shown that soleus-derived myoblasts differently respond to an early and later stage of HS. At the early stage of HS, the proliferative activity of myoblasts was slightly decreased, and processes related to myogenesis activation were downregulated. At the later stage of HS, we observed a decrease in myoblast proliferative potential and spontaneous upregulation of the pro-myogenic program.
Digital cervical cancer screening: a reliable One-Stop method ?

BackgroundWorldwide, cervical cancer (CC) is considered the fourth most common cancer in women. Globocandata stated 311,365 CC related mortalities in the world in 2018, 90% of them occurred in low-income countries. In Jordan, CC ranks as the 12th most common cancer among women. The primary aim of this report is to be able to decide if digital screening (DS) is reliable and worth using in our one stop gynecology clinics. Materials and MethodsThis study was done for all women who attended one stop out-patient gynecology services for routine CC screening between 1/1/2019 and 31/12/2019. Inclusion criteria requested women to be 18 years of age or more, healthy, and had previously normal cervical smear (conventional Pap smear (CPS) or Liquid based cytology (LBC)) i.e., all previous screening tests results were normal. ResultsA total number of 94 patients agreed to have the DS method done, mean age was 43 years. 25.5% were found to have abnormal screening results on DS. When compared to the national data of 12.5% abnormal smears in Liquid‐based cytology (LBC), there was a statistically significant difference in the numbers of abnormal screening results between both methods (p value of 0.000). LBC is used in most centers for CCS in Jordan ConclusionThe digital cervical screening method saves time and offers a one stop clinic management, therefore minimizing lost to follow up rate, and where colposcopy is indicated. Additionally, DS should be considered in low resource countries.
Multi Objective FSSO Optmized Vertical Handoff Algorithm for Software Defined Access Network

- The possibility of programmable organizations has presently re-picked up significant speed because of the rise of the product depicted Networking (SDN) worldview. SDN, every now and again known as a "revolutionary new idea in systems administration", vows to emphatically work on local area the executives and empower advancement through network programmability. Vertical handoff is viewed as a vital period of SDNs to sup-port cell clients switch between organizations of different Radio access innovation's. it's far planned under the thoughts of improving the pleasant of-supplier necessities and device help usage. on this artworks, we build a multi-objective advancement rendition for vertical hand-off to clear up the issue that ongoing vertical handoff calculations do now not thoroughly remember the impact of clients and the organization all through handoff process. The metaheuristic set of rules of squirrel inquiry improvement (SSO) is utilized to cure the handoff issues in SDN. The proposed form is carried out utilizing python environmental elements and broke down as far as throughput, impeding and bundle dropping possibilities.
Sandfly-Borne Phleboviruses in Portugal: Four and Still Counting

According to ICTV, there are currently 66 known phlebovirus species. More than 40 of these viruses were isolated or detected in phlebotomine sandflies and some of them are known pathogens. In Portugal, information about sandfly-borne phleboviruses is scarce and scattered sandfly-borne diseases are neglected and often not considered in differential diagnoses. The main objective of this work was to gather the existing information and to raise awareness about the circulating phleboviruses in this country. To date, Massilia and Alcube phleboviruses have been isolated from sandflies in southern Portugal. Human infections with Toscana and Sicilian phleboviruses have been reported, as well as seroprevalence in cats and dogs. More studies are needed in order to understand if the viruses isolated during the entomological surveys have an impact on human health and to fully understand the real importance of the already recognized pathogens in our country.
Identifikasi Dini Kerusakan Jalan Flexible Pavement Dengan Menggunakan Algoritma PCA

Identifikasi of road damage and how to handle early is important so that the use of the road remains optimally. The delay in the repair process will exacerbate the damage to the road itself, and will certainly increase the cost of repairs. PCA algorithm was chosen because it is a technique that is commonly used to draw the features of the data on a high-dimensional scale. While the input of the system that is built in the form of a digital image of the damaged roads, has a relatively large dimensions to be used directly by the algorithm of pattern recognition, such as neural networks. Research results obtained this type of cracking cracked 67% and cracking the other 33%. This can be caused by a few things, namely the shooting process is not perfect, as the distance is too far, the less light, the edge detection process less well due to the method used is not appropriate. Index Terms—road damage, PCA, cracking, image, egde detection
Simultaneous measurement of pressure and temperature in a supersonic ejector using FBG sensors

In this work, we have demonstrated the use of fiber Bragg grating (FBG) sensors for simultaneous measurement of wall static pressure and temperature in a supersonic ejector. Supersonic ejectors are ground-based high-speed aerodynamic test facilities characterized by harsh conditions, such as high pressure and temperature gradients. An FBG-based sensor setup was developed consisting of a pressure measuring bare FBG and a specially designed pressure-insensitive FBG temperature probe that can be mounted on the wall of the supersonic ejector. The FBG temperature probe was used for temperature measurement as well as temperature compensation of the pressure measuring FBG sensor. Wall static pressure measurements in the supersonic ejector were carried out at different tank pressures and Mach number flows. The FBG pressure measurements were validated with those of standard piezoresistive-based sensor measurements. Both responses were found to match closely, with FBG sensors having a faster response time and higher pressure resolution. Fluid structure interaction simulation was carried out in Comsol Multiphysics to understand the interaction of high-speed turbulent flow with FBG sensor. The FBG strain profile due to flow-induced stress and its dependence on flow pressure was studied. A detailed analysis of the effect of preceding fiber length on FBG pressure measurement was carried out. FBG sensors, due to their miniature size, ability to withstand harsh environments and multi-parameter sensing capability, can be used in ground-based aerodynamic test facilities with minimal intrusion into the flow.
Sustainable Control Tactics of the Cereal Leafminer Syringopais Temperatella Led. (Lep., Scythrididae) in Jordan: Resistant Cultivars and Combined Use of Tillage and Insecticides

The cereal leafminer, Syringopais temperatella Led. (Lep., Scythrididae) is considered one of the most serious insect pests that infests wheat in the field, and causes economic damages to the crop in Jordan. However, little attention has been paid to the susceptibility of common wheat cultivars and no attention has been paid to the combined use of tillage regime and insecticides against S. temperatella. Concomitan tly, this study aimed at investigating the susceptibility of the most commonly grown wheat cultivars in Jordan to S. temperatella under field conditions, and the effect of the combined use of tillage regime and insecticide applications in controlling the pest on wheat. The 1st experiment was set up to determine the susceptibility of four common wheat cultivars to the pest in the 2016/2017 cropping season, while the 2nd one was set up to investigate the effect of the combined use of tillage regime and insecticides against the pest in 2017/2018 cropping season in Al-Qasr, Karak. Four common wheat cultivars (Deer Alla, Em-Qees, Sham, and Horani 27), were used in the 1st experiment, while in the 2nd experiment, 6 different treatments were done using the wheat cultivar, Horani 27, namely, T1: no-tillage, T2: deep plowing in summer, T3: deep plowing in summer and treating seeds with diazinon, T4: chisel plow at seed sowing time with treating seeds with diazinon, T5: no-tillage and treating seeds with diazinon, and T6: chisel plow at seed sowing time. In the two experiments, data on larvae number, infestation, grain and straw weights, and plant height were recorded. Results showed that infestation and larvae numbers were the lowest, and grain and straw weights were the highest in Horani 27 compared to other cultivars. Data showed that the lowest infestation and larvae number were obtained in the no-tillage, and grain and straw weights were the highest in deep plowing in summer and treating seeds with diazinon. While the tallest plant was recorded in deep plowing in summer and deep plowing in summer by treating seeds with diazinon. In conclusion, Horani 27 is the least susceptible cultivar to the pest, and no-tillage reduces larvae number and infestation while plowing in summer by treating seeds with diazinon increased yield and strawweight, and plant height.
Activity of Apo-Lactoferrin on Pathogenic Protozoa

Parasites and other eventually pathogenic organisms require the ability to adapt to different environmental conditions inside the host to assure survival. Some host proteins have evolved as defense constituents, such as lactoferrin (Lf), which is part of the innate immune system. Lf in its iron-free form (apo-Lf) and its peptides obtained by cleavage with pepsin are microbicides. Parasites confront Lf in mucosae and blood. In this work, the activity of Lf against pathogenic and opportunistic parasites such as Cryptosporidium spp. , Eimeria spp. , Entamoeba histolytica, Giardia duodenalis, Leishmania spp. , Trypanosoma spp. , Plasmodium spp. , Babesia spp. , Toxoplasma gondii, Trichomonas spp. , and the free-living but opportunistic pathogens Naegleria fowleri and Acanthamoeba castellani were reviewed. The major effects of Lf could be the inhibition produced by sequestering the iron needed for their survival and the production of oxygen-free radicals to more complicated mechanisms, such as the activation of macrophages to phagocytes with the posterior death of those parasites. Due to the great interest in Lf in the fight against pathogens, it is necessary to understand the exact mechanisms used by this protein to affect their virulence factors and to kill them.
2–18 GHz balanced antipodal Vivaldi conformal phased array antenna with resistive load and shorting posts

In this paper, a 2–18 GHz balanced antipodal Vivaldi conformal phased array antenna is proposed. Firstly, the conformal array achieves a low profile of 0. 11λLow by using the tightly coupling mechanism. Here, the gap‐induced element resonance (GIER) and the common mode resonance occur in the operating band, limiting the impedance bandwidth. Thus, the resistors are loaded to eliminate the GIER by suppressing the resonant current. Furthermore, the shorting posts are used to remove the common mode resonance by decreasing the resonant length. A transition structure between the stripline (SL) and the ground coplanar waveguide (GCPW) is designed to feed the antenna. The simulated results show that the array achieves a 9:1 bandwidth (2–18 GHz) for active VSWR <2.5 at broadside. Besides, the active VSWR is less than 2.5 for ±60° scanning in E‐plane and 3.8 for ±45° scanning in H‐plane. A 12 × 8 array prototype is fabricated and measured to validate the performance of the array. The measured results show a good agreement with the simulation.
Classification of Deprivation Indices That Applied to Detect Health Inequality: A Scoping Review

Introduction: Many studies around the world are undertaken to establish the association between deprivation and public health indicators. Both separate indicators (e.g., income, education, occupation, public security and social support) and complex models (indices) include several indicators. Deprivation indices are actively used in public health since the mid 1980s. There is currently no clear classification of indices. Methods: In the current review, data related to deprivation indices are combined and analyzed in order to create a taxonomy of indices based on the results obtained. The search was carried out using two bibliographic databases. After conducting a full-text review of the articles and searching and adding relevant articles from the bibliography, and articles that were already known to the authors, sixty studies describing the use of sixty deprivation indices in seventeen countries were included in the narrative synthesis, resulting in development of a taxonomy of indices. When creating the taxonomy, an integrative approach was used that allows integrating new classes and sub-classes in the event that new information appears. Results: In the review, 68% (41/60) of indices were classified as socio-economic, 7% (4/60) of indices as material deprivation, 5% (3/60) of indices as environmental deprivation and 20% (12/60) as multidimensional indices. Conclusions: The data stimulates the use of a competent approach, and will help researchers and public health specialist in resolving conflicts or inconsistencies that arise during the construction and use of indices.
A Hybrid Route Selection Scheme for 5G Network Scenarios: An Experimental Approach

With the significant rise in demand for network utilization, such as data transmission and device-to-device (D2D) communication, fifth-generation (5G) networks have been proposed to fill the demand. Deploying 5G enhances the utilization of network channels and allows users to exploit licensed channels in the absence of primary users (PUs). In this paper, a hybrid route selection mechanism is proposed, and it allows the central controller (CC) to evaluate the route map proactively in a centralized manner for source nodes. In contrast, source nodes are enabled to make their own decisions reactively and select a route in a distributed manner. D2D communication is preferred, which helps networks to offload traffic from the control plane to the data plane. In addition to the theoretical analysis, a real testbed was set up for the proof of concept; it was composed of eleven nodes with independent processing units. Experiment results showed improvements in traffic offloading, higher utilization of network channels, and a lower interference level between primary and secondary users. Packet delivery ratio and end-to-end delay were affected due to a higher number of intermediate nodes and the dynamicity of PU activities.
Atractylone Alleviates Ethanol-Induced Gastric Ulcer in Rat with Altered Gut Microbiota and Metabolites

Background Gastric ulcer (GU) is the most common multifactor gastrointestinal disorder affecting millions of people worldwide. There is evidence that gut microbiota is closely related to the development of GU. Atractylone (ATR) has been reported to possess potential biological activities, but research on ATR alleviating GU injury is unprecedented. Methods Helicobacter pylori (H. pylori)-induced GU model in zebrafish and ethanol-induced acute GU model in rat were established to evaluate the anti-inflammatory and ulcer inhibitory effects of ATR. Then, 16S rRNA sequencing and metabolomics analysis were performed to investigate the effect of ATR on the microbiota and metabolites in rat feces and their correlation. Results Therapeutically, ATR inhibited H. pylori-induced gastric mucosal injury in zebrafish. In the ulceration model of rat, ATR mitigated the gastric lesions damage caused by ethanol, decreased the ulcer area, and reduced the production of inflammatory factors. Additionally, ATR alleviated the gastric oxidative stress injury by increasing the activity of superoxide dismutase (SOD) and decreasing the level of malondialdehyde (MDA). Furthermore, ATR played a positive role in relieving ulcer through reshaping gut microbiota composition including Parabacteroides and Bacteroides and regulating the levels of metabolites including amino acids, short-chain fatty acids (SCFAs), and bile acids. Conclusion Our work sheded light on the mechanism of ATR treating GU from the perspective of the gut microbiota and explored the correlation between gut microbiota, metabolites, and host phenotype.
Lack of Bone Mineral Density Testing in Men With Hypogonadism: A Clinical Conundrum

Abstract Context The 2012 Endocrine Society Clinical Practice Guidelines recommend that men aged 50 years or older with a diagnosis of hypogonadism undergo bone mineral density (BMD) testing. Objective The objective of this study was to determine the frequency at which men aged 50 years or older with a diagnosis of hypogonadism undergo BMD testing, and if found to have low BMD, are subsequently treated with an osteoporosis medication. Methods A retrospective chart review was conducted at a large academic medical center. Inclusion requirements were an International Classification of Diseases (ICD)-9 or -10 code for hypogonadism at any time between July 1, 2012 and September 30, 2020. Patients were followed until the date of BMD assessment or censoring (September 30, 2021). BMD results and treatment with osteoporosis medication were recorded. Results A total of 10 169 men with hypogonadism were identified, of whom the mean age was 63.4 (± 9.2), 86.3% White, mean body mass index 31.3 with prevalence of chronic kidney disease, type 2 diabetes, and hypertension of 20.6%, 36.9%, and 68.2%, respectively. The percentage that underwent BMD testing was 7.2%, of which 352 (48.4%) and 87 (12.0%) had osteopenia and osteoporosis, respectively. Among the 87 patients with osteoporosis, 57.5% were treated with an osteoporosis medication. Conclusion Only 7.2% of hypogonadal men underwent BMD testing, and among them, 12.0% were found to have osteoporosis. Among those with osteoporosis, 57.5% underwent treatment with osteoporosis medication. Further studies are needed to determine why so few men with hypogonadism undergo BMD assessment and what systems can be put in place to overcome this clinical conundrum.
Impact of Carbon Nanotubes on the AC Breakdown of Mineral Oil with the Presence of Polyvinylpyrrolidone

The research on the nanofluid as an alternative transformer oil has been widely attracted the concern of many researchers as the effectiveness as insulation and cooling agent of the existing transformer oil is not achieved satisfactory to accommodate the rising demand of high voltage rate. In this study, nanofluid with a nanomaterial, Carbon Nanotube (CNT), with and without Polyvinylpyrrolidone (PVP) has been formulated, and their AC breakdown voltage of the mineral oil (MO) according to IEC 60156 standard has been characterized. The concentration of CNT study is 0.005, 0.01, 0.015 and 0.02 g/L. It is found that the optimum concentration in nanofluids without PVP is 0.005g/L of nanofluids concentration with the highest breakdown voltage 53.52. In comparison, the highest breakdown voltage for nanofluids with PVP is 33.4kV at 0.01g/L. The existence of PVP in the nanofluids seems not significantly affect the dielectric performance of the degradation of the nanofluid from 5% to 43%. Hence, nanofluids with CNT addition are proofed as a good additive in insulation oil for future transformer applications.
Modeling of Excess‐3 to BCD code converter for nano system using quantum‐dot cellular automata technology

This work proposes a novel quantum‐dot cellular automata (QCA) layout for an Excess‐3 to BCD code converter for nano systems that is low in cell complexity. The suggested design uses a QCA clock‐phase‐based technique to evaluate integration with other complex circuits. The results obtained using the QCADesigner simulation tool demonstrate the superiority of the recommended layout over prior identical reverse counterpart designs by evaluating the cell numbers used, the space occupied, and the latency as design metrics. The suggested layout has a 56% decrease in occupied space and a 37.5% reduction in delay when compared to similar reverse counterpart scalable designs. In addition, the energy dissipation of the suggested structure was calculated and compared to previous comparable work (reverse equivalent) to confirm its reliability. The suggested circuit may be employed in bigger and more complicated circuits due to its advantage in numerous performance measurement parameters.
Detection methods for depth profiling of light elements using high energy alpha particles

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A Deep Learning Computer-Aided Diagnosis Approach for Breast Cancer

Breast cancer is a gigantic burden on humanity, causing the loss of enormous numbers of lives and amounts of money. It is the world’s leading type of cancer among women and a leading cause of mortality and morbidity. The histopathological examination of breast tissue biopsies is the gold standard for diagnosis. In this paper, a computer-aided diagnosis (CAD) system based on deep learning is developed to ease the pathologist’s mission. For this target, five pre-trained convolutional neural network (CNN) models are analyzed and tested—Xception, DenseNet201, InceptionResNetV2, VGG19, and ResNet152—with the help of data augmentation techniques, and a new approach is introduced for transfer learning. These models are trained and tested with histopathological images obtained from the BreakHis dataset. Multiple experiments are performed to analyze the performance of these models through carrying out magnification-dependent and magnification-independent binary and eight-class classifications. The Xception model has shown promising performance through achieving the highest classification accuracies for all the experiments. It has achieved a range of classification accuracies from 93.32% to 98.99% for magnification-independent experiments and from 90.22% to 100% for magnification-dependent experiments.