Miracle-dz/UniFAR-FTUs huggingface dataset:
CHIME Ages of Monazites from Metamorphic Rocks from the Precambrian Gyeonggi Gneiss Complex in the Shiheung and Seosan Group of the Gyeonggi Massif, South Korea

CHIME ages were obtained from monazites in metamorphic rocks from the Seosan and Siheung Groups in the Gyeonggi gneiss complex, Korean peninsula. Monazite CHIME ages range from 234 to 257 Ma, corresponding to the late Permian to middle Triassic Songrim disturbance due to the collision event between the North and South China blocks within the Gyeonggi gneiss complex in the Korean peninsula. The CHIME ages are consistent with the metamorphic ages from the Hongseong area (231 Ma, Kim et al., 2006) and the Odesan area (245-248 Ma, Oh et al., 2006b) in the Gyeonggi gneiss complex and are older than those from the Dabie-Sulu collision belt (220242 Ma, Yang or of., 2003; Liu et al., 2003, 2004) suggesting that the collision between the North and South China blocks had occurred earlier in Korea than China.
Omega-3 meat enrichment and L-FABP, PPARA, and LPL genes expression are modified by the level and period of tuna oil supplementation in slow-growing chickens

Abstract This study proposes a strategy to manipulate the fatty acid (FA) content in slow-growing Korat chicken (KRC) meat using tuna oil (TO). To determine the optimal level and feeding period of TO supplementation, we conducted a study investigating the effects of dietary TO levels and feeding periods on meat quality, omega-3 polyunsaturated fatty acid (n-3 PUFA) composition, and gene expression related to FA metabolism in KRC breast meat. At 3 wk of age, 700 mixed-sex KRC were assigned to seven augmented factorial treatments with a completely randomized design, each consisting of four replicate pens containing 25 chickens per pen. The control group received a corn-soybean-based diet with 4.5% rice bran oil (RBO), while varying amounts of TO (1.5%, 3.0%, or 4.5%) replaced a portion of the RBO content in the experimental diets. The chickens were fed these diets for 3 and 6 wk, respectively, before being slaughtered at 9 wk. Our results indicated no significant interactions between TO levels and feeding periods on the growth performance or meat quality of KRC (P > 0.05). However, the liver fatty acid-binding protein gene (L-FABP, also known as FABP1), responsible for FA transport and accumulation, showed significantly higher expression in the chickens supplemented with 4.5% TO (P < 0.05). The chickens supplemented with 4.5% TO for a longer period (3 to 9 wk of age) exhibited the lowest levels of n-6 PUFA and n-6 to n-3 ratio, along with the highest levels of eicosapentaenoic acid, docosahexaenoic acid, and n-3 PUFA in the breast meat (P < 0.05). However, even a short period of supplementation with 4.5% TO (6 to 9 wk of age) was adequate to enrich slow-growing chicken meat with high levels of n-3 PUFA, as recommended previously. Our findings indicated that even a short period of tuna oil supplementation could lead to desirable levels of omega-3 enrichment in slow-growing chicken meat. This finding has practical implications for the poultry industry, providing insights into optimal supplementation strategies for achieving desired FA profiles without adversely affecting growth performance or meat quality.
Mühendislik Verilerinde Tek Örnek İçin Parametrik ve Parametrik Olmayan Testler

Veriler normal olarak dagildiginda Tek ornek T- Testi uygulanmalidir. Aksi durumda Wilcoxon Tek Ornek Isaret Siralamasi Testi tercih edilmelidir. Wilcoxon Tek Ornek Isaret Siralamasi Testi Tek ornek T-testinin nonparametrik karsiligidir. Parametrik testlerin uygulama kosullari cogunlukla yerine getirilemediginden, bu tekniklerin alternatifi olan non-parametrik testlerin kullanimi kacinilmaz olmaktadir. Bu arastirmada normal dagilimi test etmek icin kullanilan sut pH verileri 1. ve 2. gun icin bir ciftlikte yetistirilen 9 adet inekten elde edilmistir. Mevcut calismadan elde edilen bulgulara gore 1. gun sut pH verileri normal dagilim gostermistir. Bununla birlikte 2. gun verileri normal dagilim gostermemislerdir. 2. gun verilerinden elde edilen onemli p degerinden (0.000) de goruldugu gibi, 2. gun verilerine tek ornek t testi uygulamamiz mumkun degildir. 2. gun verilerine Wilcoxon Tek Ornek Isaret Siralamasi Testi uygulanmalidir.
Cultural diversity in health care teams: A systematic integrative review and research agenda

Background Although team-based work is deemed key to improving the quality of national health care systems, adverse events related to teamwork account for up to one third of all incidents. Health care teams are typically multiprofessional and diverse in many aspects, but cultural diversity is one of the most challenging. Purposes The objective of this review is to systematically analyze the literature to better understand the impact of cultural diversity in health care teams on team processes as well as team and patient outcomes. This study also explores the conditions that enable or hinder team functioning. Methodology Through a systematic integrative literature review, this study builds on the input–process–output–context framework. Multiple searches of the main databases led to identifying 43 relevant articles. Findings The results suggest that, when not proactively managed, cultural diversity may have a negative effect on team communication and integration, increasing team conflict and thereby negatively influencing team performance, team climate, and patient safety, both directly and indirectly. Yet, when managed properly and in the presence of engaged and culturally sensitive leadership, cultural training, and open and transparent procedures, cultural diversity in health care teams can be an asset to health care organizations. Analyzing and aggregating these findings into an integrative framework, our study identifies several themes and a research agenda for future studies on culturally diverse health care teams. Practice Implications Our findings suggest that culturally diverse health care teams experience a number of challenges, pointing to the need for action or structures that enable these teams to perform better, such as emphasizing learning and allowing team members time to get to know each other outside work.
Silver electroceutical technology to treat sarcopenia

Significance Electrical stimulation (ES) treatment showed beneficial effects in recovering skeletal muscle in in vivo and in vitro. Therefore, many clinical studies tried to treat sarcopenia but did not show adequate rehabilitation effects. Here, we elucidate that specific ES conditions are required to recover young and aged skeletal muscle, respectively. According to the specific ES condition, our results show that calcium signaling, senescence, metabolism, and hypertrophic effects are recovered via specific ES conditions. However, suboptimal ES conditions induced muscle damage. In addition, applying specific ES conditions to the aged mice induces hypertrophy and restores contraction force. Consequently, the optimal ES condition we named “silver electroceutical” can be an alternative to treat sarcopenia.
Leaf-level metabolic changes in response to drought affect daytime CO2 emission and isoprenoid synthesis pathways

Abstract In the near future, climate change will cause enhanced frequency and/or severity of droughts in terrestrial ecosystems, including tropical forests. Drought responses by tropical trees may affect their carbon use, including production of volatile organic compounds (VOCs), with implications for carbon cycling and atmospheric chemistry that are challenging to predict. It remains unclear how metabolic adjustments by mature tropical trees in response to drought will affect their carbon fluxes associated with daytime CO2 production and VOC emission. To address this gap, we used position-specific 13C-pyruvate labeling to investigate leaf CO2 and VOC fluxes from four tropical species before and during a controlled drought in the enclosed rainforest of Biosphere 2 (B2). Overall, plants that were more drought-sensitive had greater reductions in daytime CO2 production. Although daytime CO2 production was always dominated by non-mitochondrial processes, the relative contribution of CO2 from the tricarboxylic acid cycle tended to increase under drought. A notable exception was the legume tree Clitoria fairchildiana R.A. Howard, which had less anabolic CO2 production than the other species even under pre-drought conditions, perhaps due to more efficient refixation of CO2 and anaplerotic use for amino acid synthesis. The C. fairchildiana was also the only species to allocate detectable amounts of 13C label to VOCs and was a major source of VOCs in B2. In C. fairchildiana leaves, our data indicate that intermediates from the mevalonic acid (MVA) pathway are used to produce the volatile monoterpene trans-β-ocimene, but not isoprene. This apparent crosstalk between the MVA and methylerythritol phosphate pathways for monoterpene synthesis declined with drought. Finally, although trans-β-ocimene emissions increased under drought, it was increasingly sourced from stored intermediates and not de novo synthesis. Unique metabolic responses of legumes may play a disproportionate role in the overall changes in daytime CO2 and VOC fluxes in tropical forests experiencing drought.
ABEUSAURUS COMAHUENSIS, N.G., N.SP., CARNOSAURIA DEL CRETACICO TARDIO DE PATAGONIA.

An almost complete skull of a carnosaur from the Allen Formation (Maasqichtian of Rio Negro Province) is described as the holotype of A belisaurus comahuensis. It is a high skull with a broad interorbital roof, a huge preorbital opening, squamosal nearly horizontal with the quadratojugal process ventraly directed, very wide infratemporal fenestra, very long quadrate, orbital opening large with almost closed orbita. The differences with Tyrannosauridae and other Cretaceous carnosaurs families appear so significant as to propose a new family, Abelisauridae, likely of gondwanic distribution. ·
Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study.

PURPOSE Gemcitabine plus cisplatin (GC) and methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) were compared in patients with locally advanced or metastatic transitional-cell carcinoma (TCC) of the urothelium. PATIENTS AND METHODS Patients with stage IV TCC and no prior systemic chemotherapy were randomized to GC (gemcitabine 1,000 mg/m2 days 1, 8 and 15; cisplatin 70 mg/m2 day 2) or standard MVAC every 28 days for a maximum of six cycles. RESULTS Four hundred five patients were randomized (GC, n = 203; MVAC, n = 202). The groups were well-balanced with respect to prognostic factors. Overall survival was similar on both arms (hazards ratio [HR], 1.04; 95% confidence interval [CI], 0.82 to 1.32; P = .75), as were time to progressive disease (HR, 1.05; 95% CI, 0.85 to 1.30), time to treatment failure (HR, 0.89; 95% CI 0.72 to 1.10), and response rate (GC, 49%; MVAC, 46%). More GC patients completed six cycles of therapy, with fewer dose adjustments. The toxic death rate was 1% on the GC arm and 3% on the MVAC arm. More GC than MVAC patients had grade 3/4 anemia (27% v 18%, respectively), and thrombocytopenia (57% v 21%, respectively). On both arms, the RBC transfusion rate was 13 of 100 cycles and grade 3/4 hemorrhage or hematuria was 2%; the platelet transfusion rate was four patients per 100 cycles and two patients per 100 cycles on GC and MVAC, respectively. More MVAC patients, compared with GC patients, had grade 3/4 neutropenia (82% v 71%, respectively), neutropenic fever (14% v 2%, respectively), neutropenic sepsis (12% v 1%, respectively), and grade 3/4 mucositis (22% v 1%, respectively) and alopecia (55% v 11%, respectively). Quality of life was maintained during treatment on both arms; however, more patients on GC fared better regarding weight, performance status, and fatigue. CONCLUSION GC provides a similar survival advantage to MVAC with a better safety profile and tolerability. This better-risk benefit ratio should change the standard of care for patients with locally advanced and metastatic TCC from MVAC to GC.
Design and Optimization of a High Gain Multiband Patch Antenna for Millimeter Wave Application

This paper presents an enhanced Quadri-band microstrip patch antenna, using defective slots in the ground plane, designed to operate in the millimeter wave band, formulated using cavity model and simulated by an EM-simulator, based on finite element method: HFSSv15 (High Frequency Structure Simulator). The proposed antenna incorporates two symmetric patterns of “U” shaped slots with an “I” shaped slot engraved in the middle of the ground plane. The resulting antenna has four frequency bands; the first resonant frequency is located in the Ka band, at about 27Ghz, the second at nearly 35Ghz, the third at 41Ghz and the last one at 51GHz. Those resonant frequencies could be shifted by tuning the slots dimensions introduced if the ground plane of the proposed antenna .
The importance of glucose‐dependent insulinotropic polypeptide receptor activation for the effects of tirzepatide

Tirzepatide is a unimolecular co‐agonist of the glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) receptors recently approved for the treatment of type 2 diabetes by the US Food and Drug Administration and the European Medicine Agency. Tirzepatide treatment results in an unprecedented improvement of glycaemic control and lowering of body weight, but the contribution of the GIP receptor‐activating component of tirzepatide to these effects is uncertain. In this review, we present the current knowledge about the physiological roles of the incretin hormones GLP‐1 and GIP, their receptors, and previous results of co‐targeting the two incretin hormone receptors in humans. We also analyse the molecular pharmacological, preclinical and clinical effects of tirzepatide to discuss the role of GIP receptor activation for the clinical effects of tirzepatide. Based on the available literature on the combination of GLP‐1 and GIP receptor activation, tirzepatide does not seem to have a classical co‐activating mode of action in humans. Rather, in vitro studies of the human GLP‐1 and GIP receptors reveal a biased GLP‐1 receptor activation profile and GIP receptor downregulation. Therefore, we propose three hypotheses for the mode of action of tirzepatide, which can be addressed in future, elaborate clinical trials.
A Learning-Based Framework for Quantized Compressed Sensing

Sparse recovery from undersampled random quantization measurements is a recent active research topic. Previous work asserts that stable recovery can be guaranteed via the basis pursuit dequantizer (BPDQ) if the measurements number is large enough, considering random sampling patterns. In this letter, we study a learning-based method for optimizing the sampling pattern, within the framework of sparse recovery via BPDQ from their uniformly quantized measurements. Given a set of representative training signals, the method finds the sampling pattern that performs the best on average over these signals. We compare our approach with the random sampling and other state-of-the-art sampling methods, which shows that it achieves superior reconstruction performance. We demonstrate that proper accounting for sampling and careful sampler design has a significant impact on the performance of quantized compressive sensing methods.
Intake of Fruit and Glycemic Control in Korean Patients with Diabetes Mellitus Using the Korea National Health and Nutrition Examination Survey

Background Despite the well-recognized health benefits of fresh fruit consumption, there is still substantial uncertainty about its potential effects on glycemic control in patients with type 2 diabetes mellitus (T2DM). Methods We examined the association of fresh fruit consumption and glycemic control in patients with T2DM using data from the 6th Korea National Health and Nutrition Examination Survey. The study sample was divided into three groups based on weekly fruit consumption frequency for the analysis. Results Patients with the highest fruit intake were older than those in the other two groups, and women were more likely to consume fruits in general. Being a current smoker and weekly alcohol intake also showed negative correlations according to the fruit intake tertiles. Fruit consumption was positively correlated with better hemoglobin A1c (HbA1c) levels. Moreover, patients in the highest tertile of fruit intake were 3.48 times more likely to be in good glycemic control defined as HbA1c <7%. Conclusion We observed that fruit consumption can be helpful in glycemic control in Korean patients with T2DM.
The metagenome‐derived esterase PET40 is highly promiscuous and hydrolyses polyethylene terephthalate (PET)

Polyethylene terephthalate (PET) is a widely used synthetic polymer and known to contaminate marine and terrestrial ecosystems. Only few PET‐active microorganisms and enzymes (PETases) are currently known, and it is debated whether degradation activity for PET originates from promiscuous enzymes with broad substrate spectra that primarily act on natural polymers or other bulky substrates, or whether microorganisms evolved their genetic makeup to accepting PET as a carbon source. Here, we present a predicted diene lactone hydrolase designated PET40, which acts on a broad spectrum of substrates, including PET. It is the first esterase with activity on PET from a GC‐rich Gram‐positive Amycolatopsis species belonging to the Pseudonocardiaceae (Actinobacteria). It is highly conserved within the genera Amycolatopsis and Streptomyces. PET40 was identified by sequence‐based metagenome search using a PETase‐specific hidden Markov model. Besides acting on PET, PET40 has a versatile substrate spectrum, hydrolyzing δ‐lactones, β‐lactam antibiotics, the polyester‐polyurethane Impranil® DLN, and various para‐nitrophenyl ester substrates. Molecular docking suggests that the PET degradative activity is likely a result of the promiscuity of PET40, as potential binding modes were found for substrates encompassing mono(2‐hydroxyethyl) terephthalate, bis(2‐hydroxyethyl) terephthalate, and a PET trimer. We also solved the crystal structure of the inactive PET40 variant S178A to 1.60 Å resolution. PET40 is active throughout a wide pH (pH 4–10) and temperature range (4–65 °C) and remarkably stable in the presence of 5% SDS, making it a promising enzyme as a starting point for further investigations and optimization approaches.
Effects of a Theory-Based Educational Program on Health Behaviors and Cardiovascular Health Outcomes Among Overweight Postmenopausal Women

Background With the natural cessation of estrogen, after menopause, women, especially those who are overweight, are at a high risk for cardiovascular disease. Diet control and adequate physical activity (PA) are recommended as the essence of promoting cardiovascular health for women after menopause. Objective The aim of this study was to examine the effects of a theory-based educational program on health behaviors and cardiovascular health outcomes among overweight postmenopausal Chinese women compared with conventional didactic education. Methods In this randomized controlled trial, 288 participants were randomly allocated to intervention (n = 144) or control (n = 144) groups. The control group received conventional didactic education. The intervention group received a 3-month theory-based educational program. Primary outcomes were PA and dietary behavior. Secondary outcomes included cardiovascular health knowledge, self-efficacy in PA and diet, and cardiovascular health outcomes. Data were collected at baseline (T0), 3 months (T1), 6 months (T2), and 12 months (T3). Results The intervention group demonstrated significantly greater improvements in PA, dietary behavior, self-efficacy in PA and diet, and several cardiovascular health outcomes (body weight, body mass index, waist circumference, blood pressure, and Framingham risk score [body mass index]) at postintervention compared with the control group (all Ps < .05). These significant effects maintained at T2, and the effects on self-efficacy in PA and diet also were maintained at T3. Conclusions A theory-based educational program may be an effective strategy for improving PA, dietary behavior, self-efficacy in PA and diet, and several cardiovascular health outcomes for overweight postmenopausal Chinese women. However, further strategies are needed to enhance the sustainability of the positive changes.
Cytokine receptor-like factor 1 (CRLF1) promotes cardiac fibrosis via ERK1/2 signaling pathway

Cardiac fibrosis is a cause of morbidity and mortality in people with heart disease. Anti-fibrosis treatment is a significant therapy for heart disease, but there is still no thorough understanding of fibrotic mechanisms. This study was carried out to ascertain the functions of cytokine receptor-like factor 1 (CRLF1) in cardiac fibrosis and clarify its regulatory mechanisms. We found that CRLF1 was expressed predominantly in cardiac fibroblasts. Its expression was up-regulated not only in a mouse heart fibrotic model induced by myocardial infarction, but also in mouse and human cardiac fibroblasts provoked by transforming growth factor-β1 (TGF-β1). Gain- and loss-of-function experiments of CRLF1 were carried out in neonatal mice cardiac fibroblasts (NMCFs) with or without TGF-β1 stimulation. CRLF1 overexpression increased cell viability, collagen production, cell proliferation capacity, and myofibroblast transformation of NMCFs with or without TGF-β1 stimulation, while silencing of CRLF1 had the opposite effects. An inhibitor of the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway and different inhibitors of TGF-β1 signaling cascades, comprising mothers against decapentaplegic homolog (SMAD)-dependent and SMAD-independent pathways, were applied to investigate the mechanisms involved. CRLF1 exerted its functions by activating the ERK1/2 signaling pathway. Furthermore, the SMAD-dependent pathway, not the SMAD-independent pathway, was responsible for CRLF1 up-regulation in NMCFs treated with TGF-β1. In summary, activation of the TGF-β1/SMAD signaling pathway in cardiac fibrosis increased CRLF1 expression. CRLF1 then aggravated cardiac fibrosis by activating the ERK1/2 signaling pathway. CRLF1 could become a novel potential target for intervention and remedy of cardiac fibrosis.
Beaver Reintroduction Correlates with Spotted Frog Population Restoration and Terrestrial Movement Patterns of Newly Metamorphosed Columbia Spotted Frogs in the Owyhee Uplands of Southwestern Idaho

iv LIST OF TABLES . viii LIST OF FIGURES . ix CHAPTER I: AN OVERVIEW OF THE ECOLOGY AND CONSERVATION STATUS OF COLUMBIA SPOTTED FROGS (Rana luteiventris) IN FRAGMENTED HABITAT PATCHES IN THE OWYHEE UPLANDS OF SOUTHWESTERN IDAHO .
Stability Verification of Quantum non-i.i.d. sources

We introduce the problem of stability verification of quantum sources which are non-i.i. d. The problem consists in ascertaining whether a given quantum source is stable or not, in the sense that it produces always a desired quantum state or if it suffers deviations. Stability is a statistical notion related to the sparsity of errors. This problem is closely related to the problem of quantum verification first proposed by Pallister et. al. [1], however, it extends the notion of the original problem. We introduce a family of states that come from these non-i.i. d. sources which we call a Markov state. These sources are more versatile than the i.i. d. ones as they allow statistical deviations from the norm instead of the more coarse previous approach. We prove in theorem 1 that the Markov states are not well described with tensor products over a changing source. In theorem 2 we further provide a lower bound on the trace distance between two Markov states, or conversely, an upper bound on the fidelity between these states. This is a bound on the capacity of determining the stability property of the source, which shows that it is exponentially easier to ascertain this with respect to n, the number of outcomes from the source.