Miracle-dz/UniFAR-FTUs huggingface dataset:
Neuroscience and CSR: Using EEG for Assessing the Effectiveness of Branded Videos Related to Environmental Issues

The majority of studies evaluating the effectiveness of branded CSR campaigns are concentrated and base their conclusions on data collection through self-reporting questionnaires. Although such studies provide insights for evaluating the effectiveness of CSR communication methods, analysing the message that is communicated, the communication channel used and the explicit brain responses of those for whom the message is intended, they lack the ability to fully encapsulate the problem of communicating environmental messages by not taking into consideration what the recipients’ implicit brain reactions are presenting. Therefore, this study aims to investigate the effectiveness of CSR video communications relating to environmental issues through the lens of the recipients’ implicit self, by employing neuroscience-based assessments. For the examination of implicit brain perception, an electroencephalogram (EEG) was used, and the collected data was analysed through three indicators identified as the most influential indicators on human behaviour. These three indicators are emotional valence, the level of brain engagement and cognitive load. The study is conducted on individuals from the millennial generation in Thessaloniki, Greece, whose implicit brain responses to seven branded commercial videos are recorded. The seven videos were a part of CSR campaigns addressing environmental issues. Simultaneously, the self-reporting results from the participants were gathered for a comparison between the explicit and implicit brain responses. One of the key findings of the study is that the explicit and implicit brain responses differ to the extent that the CSR video communications’ brain friendliness has to be taken into account in the future, to ensure success. The results of the study provide an insight for the future creation process, conceptualisation, design and content of the effective CSR communication, in regard to environmental issues.
STATCOM+BESS MODELLING AND HARMONIC ANALYSIS

In this paper, concepts of Static Compensator plus Battery Energy Storage System (STATCOM+BESS) operation, power control and modelling are reviewed. An implementation in Matlab-Simulink, considering a two level VSC based STATCOM+BESS is realized. Details of the implementation are provided and simulation results are presented. A single, aggregated 50 MVA BESS with the STATCOM connected to an external grid, is considered in the assessment. Harmonic propagation analysis is conducted by considering THD values at the point of connection of the STATCOM+BESS station.
Cross-Sectional and Longitudinal Associations of Lifestyle Behaviors with Pericardial Adipose Tissue: The MESA Study

ABSTRACT Purpose We examined associations of sedentary behavior (SB), light-intensity physical activity (LPA), and moderate-to-vigorous intensity physical activity (MVPA) with pericardial adipose tissue (PAT). Methods Adults from the Multi-Ethnic Study of Atherosclerosis were included from exam years 1 (2000–2002; N = 6057; mean age, 62.2 yr; 52.9% female, 38.0% White; 12.8% Chinese American, 26.7% African American, 22.5% Hispanic American), 2 (2002–2004), and 3 (2004–2005). Weekly volume of SB, LPA, and MVPA (in MET-hours per week) was reported using a questionnaire. PAT volume (in cubic centimeters) was quantified using computed tomography, analysis of covariance, and repeated-measures linear mixed models with adjustment for covariates (sociodemographics, cardiovascular disease risk factors, inflammation, waist circumference) tested cross-sectional and longitudinal associations, respectively. Results In cross-sectional analysis, the highest tertile of SB (β = 2.71; 95% confidence interval (CI), 0.69 to 4.73; P < 0.01) and the middle tertile of MVPA (β = −1.97; 95% CI, −3.92 to −0.02; P < 0.05) were associated with PAT, whereas no association was observed for LPA in fully adjusted models. In longitudinal models, SB, LPA, and MVPA were not associated with PAT in the full study sample; however, LPA was inversely associated with PAT among Whites in stratified analysis (β = −0.54; 95% CI, −0.95 to −0.13; P < 0.05). Conclusions Lower SB and higher LPA (among Whites only) and MVPA may be associated with lower PAT, but additional longitudinal research is needed.
Opti-MSFA: a toolbox for generalized design and optimization of multispectral filter arrays

Multispectral imaging captures spatial information across a set of discrete spectral channels and is widely utilized across diverse applications such as remote sensing, industrial inspection, and biomedical imaging. Multispectral filter arrays (MSFAs) are filter mosaics integrated atop image sensors that facilitate cost-effective, compact, snapshot multispectral imaging. MSFAs are pre-configured based on application—where filter channels are selected corresponding to targeted absorption spectra—making the design of optimal MSFAs vital for a given application. Despite the availability of many design and optimization approaches for spectral channel selection and spatial arrangement, major limitations remain. There are few robust approaches for joint spectral-spatial optimization, techniques are typically only applicable to limited datasets and most critically, are not available for general use and improvement by the wider community. Here, we reconcile current MSFA design techniques and present Opti-MSFA: a Python-based open-access toolbox for the centralized design and optimization of MSFAs. Opti-MSFA incorporates established spectral-spatial optimization algorithms, such as gradient descent and simulated annealing, multispectral-RGB image reconstruction, and is applicable to user-defined input of spatial-spectral datasets or imagery. We demonstrate the utility of the toolbox by comparing against other published MSFAs using the standard hyperspectral datasets Samson and Jasper Ridge, and further show application on experimentally acquired fluorescence imaging data. In conjunction with end-user input and collaboration, we foresee the continued development of Opti-MSFA for the benefit of the wider research community.
Realization of a Class of Analog Signal Processing / Signal Generation Circuits: Novel Configurations Using Current Feedback Op-Amps

In this paper, we demonstrate that, when treated as 4-terminal building blocks, the current feedback op-amps (CFOA) or transimpedance op-amps are more versatile than the traditional 3-terminal op-amps and 3-terminal Current Conveyors (CC), In realising a class of analog signal processing / signal generation functions which include impedance converters / inverters, voltage-controlled impedances (both grounded and floating), active filters (both current mode and voltage mode) and single-resistance-controlled/voltage-controlled sinusoidal oscillators. Novel CFOA-based configurations are, therefore, derivable which provide features all of which are not possible with the available op-amp-based or CC-based reallsations. The workability of the new structures is substantiated by experimental results based upon the commercially available transimpedance op-amp AD844.
An exploratory study of using speculative artefacts in co-design

ABSTRACT This paper presents a case study exploring the use of speculative artefacts framed within the Fictional Inquiry co-design technique. The case is derived from a project investigating current practices and potential future strategies to improve patients’ hand hygiene standards at the Department of Oncology of Aarhus University Hospital. This paper explores how five speculative artefacts were designed and used to inquire into participants’ experiences of their hand hygiene, both concerning current practice and future ideas. Our study demonstrates how the speculative artefacts used in Fictional Inquiry supported participant’s immersion and engagement in co-design sessions and how the artefacts were used to maintain momentum throughout the session.
Inhibiting the Musculoskeletal Pathological Processes in Post-knee Replacement Surgery With Osteopathic Manipulative Treatment: A Systematic Review

Total knee arthroplasty (TKA) is a very common surgical treatment approach for severe osteoarthritis. Complications of TKA include loss of range of motion and prolonged analgesic requirement for pain control. Osteopathic manipulative techniques (OMT) have been utilized to address localized muscular stiffness to improve range of motion; however, limited studies directly correlate OMT and TKA recovery. This review highlights the therapeutic benefits OMT can have in the postoperative management of arthroplasty with respect to range of motion, edema, pain perception, and ability to perform activities of daily living. This review revealed the use of OMT would positively influence range of motion by manipulation of localized musculature and can result in decreased demand for analgesics. This can, in turn, shorten hospital stay and return the ability of patients to perform activities of daily living earlier than without OMT. Increased research is needed to strengthen these findings on the benefits of OMT in the postoperative management of arthroplasty.
An Improved Algorithm Based on LEACH in WSN

In wireless sensor network(WSN),to effectively balance energy of nodes and prolong survival time of the network is a key problem.To solve the problem,this paper proposes an algorithm named cluster control based on low energy adaptive clustering hierarchy(CC-LEACH) based on LEACH.Using this algorithm,cluster heads are selected by the sink.Simulation results show that the method has advantages in terms of energy balance and network lifespan.
Subject To Change: Creating Great Products & Services for an Uncertain World Adaptive Path on Design (Adaptive Path)

"Short, but powerful. Easy to read, yet profound. Ive been searching for just this book: the one perfect book that summarizes the essence of modern product design. This is it. The lessons are as powerful as they are simple: The product is NOT the goal. Successful products are systems. Focus on the experience. This requires empathy, agile product management, real understanding of the target audience. This book practices what it preaches. I will use it in my courses for MBA students. You should use it for, well, for everyone. Short, simple, persuasive, and powerful. " Don Norman Author of Emotional Design and Design of Future Things Co-Founder Nielsen Norman group "Customers dont care about how innovative you are. They just want to be happy and satisfied. Learn from Adaptive Path a passion for finding and solving the problems that will matter to customers no matter what the future brings. " Scott Berkun Author, The Myths of Innovation "Wake up. The future of business isnt about flying cars and robot butlers. Creating the future is really about changing the way your company connects with its customers. Use this book as your guide. " Jeffrey Veen Design Manager, Google "Subject to Change presents complex, challenging ideas in simple, compelling language, with illuminating examples and no shortage of memorable phrases. At once authoritative and nimble, the book itself is an example of the kind of experience the authors admire. No matter who you are, it will change the way you think about design. " Michael Bierut Partner, Pentagram Author, 79 Short Essays on Design "The principles set out in Subject to Change are essential for the design of any product, but especially relevant for the fast-moving world of web software. It used to be the case that a software product was designed once, and refreshed every couple of years. Software is no longer a product. It is a process, a dynamic service that evolves as it responds to constant interaction with its users. The essence of Web 2.0 design is to create a dynamic framework that harnesses the collective intelligence of customers in such a way that the software becomes almost alive. This terrific book teaches the mindset required for this new kind of design. " Tim OReilly Founder and Publisher, OReilly Media
Extracellular matrix deposition precedes muscle-tendon integration during murine forelimb morphogenesis

The development of a functional vertebrate musculoskeletal system requires the combination of contractile muscle and extracellular matrix (ECM)-rich tendons that transmit muscle-generated force to bone. Despite the different embryologic origins, muscle and tendon integrate at the myotendinous junction (MTJ) to seamlessly connect cells and ECM across this interface. While the cell-cell signaling factors that direct development have received considerable attention, how and when the ECM linking these tissues is deposited remains unknown. To address this gap, we analyzed the 3D distribution of different ECM and the influence of skeletal muscle in forelimbs from wildype (WT) and muscle-less Pax3Cre/Cre mice. At E11.5, prior to MTJ integration, an aligned ECM was present at the presumptive insertion of the long triceps into the WT ulna. Mechanically robust tendon-like and muscle compartmentalization structures, positive for type I collagen, type V collagen, and fibrillin-2, still formed when muscle was knocked out. However, MTJ-specific ECM was not observed when muscle was absent. Our results show that an ECM-based template forms independent of muscle, but muscle is needed for the proper assembly of ECM at the MTJ. Summary statement An aligned ECM template connects tendon and muscle during limb development, independent of muscle progenitor migration into the limb; however, the assembly of MTJ-specific ECM requires the presence of muscle.
Assessment of the Readability and Quality of Online Patient Education Material for Chronic Medical Conditions

Patient education materials (PEMs) were assessed from chronic health condition associations to determine their quality and if they were above the 6th grade reading level (GRL) recommended by the Centers for Disease Control and National Institutes of Health. PEMs from 55 associations were assessed for their GRL using ten readability scales and underwent a difficult word analysis. The associations had their quality assessed using two methods: the Journal of the American Medical Association (JAMA) Benchmarks and Health on the Net Foundation Code of Conduct certification (HONCode). Two thousand five hundred and ninety PEMs, collected between June and November 2021, were analyzed. The overall GRL average was 10.8 ± 2.8, with a range of 0 to 19. Difficult word analysis showed that 15.8% ± 4.8 contained complex words of 3 or more syllables and 25.7% ± 6.3 contained words which were unfamiliar. No association displayed all four indicators of quality according to JAMA Benchmarks or held an up-to-date HONCode certification. The PEM readability continues to be written at a level above the recommended GRL. Additionally, the lack of quality indicators from the associations’ websites may make it difficult for older adults to identify the sources as credible. This represents an opportunity to optimize materials that would be understood by a wider audience.
A dual wideband high gain 2 × 2 multiple‐input‐multiple‐output monopole antenna with an end‐launch connector model for 5G millimeter‐wave mobile applications

This article presents the design, analysis, and realization of a new printed multiple‐input‐multiple‐output (MIMO) antenna with a very high gain and wide bandwidth for the millimeter‐wave (mm‐wave) 28/38 GHz fifth generation (5G) new radio (NR) applications. The proposed MIMO antenna consists of four identical patch elements in a 2 × 2 configuration to achieve high gain with wide operating bandwidth. The proposed antenna holds an attractive compact size of 31.891 × 37.528 mm2. The proposed MIMO configuration is designed on a 0.508 mm thick Rogers‐5870 substrate material with a loss tangent of 0.0009 and a relative dielectric constant of 2.33. An effective technique for folding the feed line and applying a new protruding ground is introduced to obtain good mutual coupling. The fabricated prototype of the proposed antenna is tested to verify the simulation results for the validation of the suggested design approach. The suggested MIMO antenna exhibits −10 dB impedance bandwidth of 2.6 GHz (27.4–30.0 GHz) and 3.3 GHz (36.7–40.0 GHz) to cover the intended frequency range for 5G applications with isolation less than −22 band peak gains of 18 and 14.5 dBi at 27.5 and 38.8 GHz, respectively. To validate the MIMO performance of the proposed antenna several MIMO diversity parameters such as mean effective gain (MEG), envelope correlation coefficient (ECC), and diversity gain (DG) are evaluated. Determined results indicate ECC < 0.001, DG > 9.995, and an average MEG of −3 dB at the operating bands. The proposed antenna exhibits good agreement between the simulated and measured results, which confirm its suitability for forthcoming mm‐wave 5G MIMO systems and services.
Human Hair Follicle-Derived Mesenchymal Stromal Cells from the Lower Dermal Sheath as a Competitive Alternative for Immunomodulation

Mesenchymal stromal cells (MSCs) have unique immunomodulatory capacities. We investigated hair follicle-derived MSCs (HF-MSCs) from the dermal sheath, which are advantageous as an alternative source because of their relatively painless and minimally risky extraction procedure. These cells expressed neural markers upon isolation and maintained stemness for a minimum of 10 passages. Furthermore, HF-MSCs showed responsiveness to pro-inflammatory environments by expressing type-II major histocompatibility complex antigens (MHC)-II to a lesser extent than adipose tissue-derived MSCs (AT-MSCs). HF-MSCs effectively inhibited the proliferation of peripheral blood mononuclear cells equivalently to AT-MSCs. Additionally, HF-MSCs promoted the induction of CD4+CD25+FOXP3+ regulatory T cells to the same extent as AT-MSCs. Finally, HF-MSCs, more so than AT-MSCs, skewed M0 and M1 macrophages towards M2 phenotypes, with upregulation of typical M2 markers CD163 and CD206 and downregulation of M1 markers such as CD64, CD86, and MHC-II. Thus, we conclude that HF-MSCs are a promising source for immunomodulation.
The Role of Sphingolipid Signaling in Oxidative Lung Injury and Pathogenesis of Bronchopulmonary Dysplasia

Premature infants are born with developing lungs burdened by surfactant deficiency and a dearth of antioxidant defense systems. Survival rate of such infants has significantly improved due to advances in care involving mechanical ventilation and oxygen supplementation. However, a significant subset of such survivors develops the chronic lung disease, Bronchopulmonary dysplasia (BPD), characterized by enlarged, simplified alveoli and deformed airways. Among a host of factors contributing to the pathogenesis is oxidative damage induced by exposure of the developing lungs to hyperoxia. Recent data indicate that hyperoxia induces aberrant sphingolipid signaling, leading to mitochondrial dysfunction and abnormal reactive oxygen species (ROS) formation (ROS). The role of sphingolipids such as ceramides and sphingosine 1-phosphate (S1P), in the development of BPD emerged in the last decade. Both ceramide and S1P are elevated in tracheal aspirates of premature infants of <32 weeks gestational age developing BPD. This was faithfully reflected in the murine models of hyperoxia and BPD, where there is an increased expression of sphingolipid metabolites both in lung tissue and bronchoalveolar lavage. Treatment of neonatal pups with a sphingosine kinase1 specific inhibitor, PF543, resulted in protection against BPD as neonates, accompanied by improved lung function and reduced airway remodeling as adults. This was accompanied by reduced mitochondrial ROS formation. S1P receptor1 induced by hyperoxia also aggravates BPD, revealing another potential druggable target in this pathway for BPD. In this review we aim to provide a detailed description on the role played by sphingolipid signaling in hyperoxia induced lung injury and BPD.
Role of the Mediator Complex and MicroRNAs in Breast Cancer Etiology

Transcriptional coactivators play a key role in RNA polymerase II transcription and gene regulation. One of the most important transcriptional coactivators is the Mediator (MED) complex, which is an evolutionary conserved large multiprotein complex. MED transduces the signal between DNA-bound transcriptional activators (gene-specific transcription factors) to the RNA polymerase II transcription machinery to activate transcription. It is known that MED plays an essential role in ER-mediated gene expression mainly through the MED1 subunit, since estrogen receptor (ER) can interact with MED1 by specific protein–protein interactions; therefore, MED1 plays a fundamental role in ER-positive breast cancer (BC) etiology. Additionally, other MED subunits also play a role in BC etiology. On the other hand, microRNAs (miRNAs) are a family of small non-coding RNAs, which can regulate gene expression at the post-transcriptional level by binding in a sequence-specific fashion at the 3′ UTR of the messenger RNA. The miRNAs are also important factors that influence oncogenic signaling in BC by acting as both tumor suppressors and oncogenes. Moreover, miRNAs are involved in endocrine therapy resistance of BC, specifically to tamoxifen, a drug that is used to target ER signaling. In metazoans, very little is known about the transcriptional regulation of miRNA by the MED complex and less about the transcriptional regulation of miRNAs involved in BC initiation and progression. Recently, it has been shown that MED1 is able to regulate the transcription of the ER-dependent miR-191/425 cluster promoting BC cell proliferation and migration. In this review, we will discuss the role of MED1 transcriptional coactivator in the etiology of BC and in endocrine therapy-resistance of BC and also the contribution of other MED subunits to BC development, progression and metastasis. Lastly, we identified miRNAs that potentially can regulate the expression of MED subunits.
Tolerability on Serious Adverse Events of First-Line Bevacizumab and Cetuximab for RAS Wild-Type Metastatic Colorectal Cancer: A Systematic Review and Meta-Analysis

Proper medication management is crucial in metastatic colorectal cancer because of its substantially low survival rate. There has been advancing evidence on the efficacy of the two most prescribed targeted agents (bevacizumab and cetuximab); however, comprehensive analyses on their safety are limited. This study aims to comprehensively assess the clinical safety of first-line bevacizumab and cetuximab-based chemotherapy in unresectable RAS wild-type metastatic colorectal cancer patients and to provide guidance on the selection of appropriate targeted therapeutic agents. Keyword searches of MEDLINE, Cochrane Library, and ClinicalKey were conducted per PRISMA guidelines. We performed pooled analysis on safety outcomes from six studies which administered FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin) or FOLFIRI (5-fluorouracil, leucovorin, irinotecan) as backbone chemotherapy. Thirty different adverse events from six categories were compared. First-line bevacizumab-based chemotherapy substantially lowered the risks of adverse events related to the dermatological (RR 0.24, 95% CI: 0.11–0.53, p < 0.00001) and renal systems (RR 0.57, 95% CI: 0.37–0.86, p = 0.007), while significantly increasing the incidence of cardiovascular adverse events (RR 4.65, 95% CI: 1.83–11.78, p = 0.001). Thus, first-line cetuximab-based chemotherapy increases patient susceptibility to dermatological and renal adverse events, especially with rash and electrolyte disorders, whereas bevacizumab-based chemotherapy increases cardiovascular risks such as hypertension and arrhythmia.