Miracle-dz/UniFAR-FTUs huggingface dataset:
Differences in solitary and dyadic sexual desire and sexual satisfaction in heterosexual and nonheterosexual cisgender men and women.

BACKGROUND Gender differences in sexual desire have been documented in the literature, with sexual desire being correlated with sexual satisfaction; however, data on sexual desire and sexual satisfaction among nonheterosexual samples are more limited, as are data examining sexual desire toward oneself (solitary) and another person (dyadic). AIM To examine differences between men and women, between heterosexuals and nonheterosexuals, and the interaction of gender and sexual orientation in solitary and dyadic sexual desire (partner and attractive person related) and sexual satisfaction, and to explore the predictive role of solitary and dyadic sexual desire on sexual satisfaction, controlling for gender and sexual orientation. METHODS A cross-sectional study was conducted with an online sample of 1013 participants recruited between 2017 and 2020 (552 women, 54.5%; 461 men, 45.5%; 802 heterosexuals, 79.2%; 211 nonheterosexuals, 20.8%). OUTCOMES Participants completed a web survey with a sociodemographic sheet, the Sexual Desire Inventory-2, and the Global Measure of Sexual Satisfaction. RESULTS Current findings indicated that men scored significantly higher on solitary sexual desire (P < .001, partial η2 = 0.015) and attractive person-related desire (P < .001, partial η2 = 0.015) when compared with women. Likewise, nonheterosexuals scored significantly higher on solitary sexual desire (P < .001, partial η2 = 0.053) and attractive person-related desire (P < .001, partial η2 = 0.033) vs heterosexuals. In addition, partner-related desire (β = 0.33, P < .001) was a positive and significant predictor of sexual satisfaction, whereas solitary desire (β = -0.18, P < .001) and attractive person-related desire (β = -0.23, P < .001) were negative predictors. CLINICAL IMPLICATIONS Sexual desire toward an intimate partner appears to be experienced in similar levels among heterosexual and nonheterosexual men and women, while solitary and attractive person-related sexual desire appears to be more strong among men and nonheterosexual individuals. STRENGTHS AND LIMITATIONS The current study did not use a dyadic-centered approach, only individual perceptions and experiences. However, it explored solitary sexual desire and partner- and attractive person-related sexual desire in a large sample of heterosexual and nonheterosexual men and women as predictors of sexual satisfaction. CONCLUSION Overall, men and nonheterosexual individuals experienced more solitary and attractive person-related sexual desire. In addition, partner-related sexual desire was a positive predictor of sexual satisfaction, whereas solitary sexual desire and attractive person-related desire were negative predictors of sexual satisfaction.
Two-stage impulse noise filtering algorithm based on PCNN noise detection

In order to effectively remove high dense impulse noise in images,a novel two-stage impulse noise filtering algorithm based on improved Pulse Coupled Neural Networks(PCNN)noise detection is put forward.Firstly,the noisy points and signal points are distinguished and located using the synchronous pulse burst property of PCNN,then the noisy points are smoothed by the first adaptive filter based on their local adjacent information of the noisy points,finally,the assistant filtering using the second multi-direction information median filter,which can protect edges details,is adopted.The experimental results show that the proposed algorithm needs no threshold,which has higher accuracy in the noise detection,the impulse noise can be effectively removed,and edges and details can be preserved well.Meanwhile,the denoise images obtained by the proposed algorithm have better objective quality and subjective vision effect than those by the conventional median filter(MF)and other filtering algorithm.This algorithm presents higher signal to noise ratio,stronger capability to reduce noise and better adaptive,more advantage especially to the high noisy polluted image.
Robust ring-opening reaction via asymmetrically coordinated Fe single atoms scaffolded by spoke-like mesoporous carbon nanospheres

Significance Crafting highly active metal single-atom catalysts (SAC) relies sensitively on the microstructure of introduced metal sites, including structural stability, coordination environment, etc. This work reports the creation of asymmetrically coordinated Fe SAC by nitrogen and phosphorus elements that are supported on unique mesoporous carbon nanospheres (MCNs) possessing spoke-like nanochannels (denoted Fe-N3P-MCN). Abundant interfacial unpaired electrons, confirmed by electron spin resonance, contribute to stable anchoring of Fe sites. Asymmetrical coordination of Fe atoms accelerates the electron-donating and withdrawing during the catalytic process. More intriguingly, Fe-N3P-MCN renders an ultra-high catalytic efficiency for the synthesis of an array of β-amino alcohols. They represent important organic intermediates that are widely exploited in the synthesis of pharmacologically active products, chiral ligands, and chiral auxiliaries.
Genomics-driven breeding for local adaptation of durum wheat is enhanced by farmers’ traditional knowledge

Significance Smallholder farming systems support the livelihoods of estimated two billion people on the planet. They are often characterized by challenging environments critically exposed to the climate crisis, with limited access to inputs including improved seed technology. To achieve the sustainable intesification of smallholder farming systems, crop breeding needs to tailor varietal development to local farmer needs. Here, we devise a method to integrate wheat genomics with participatory varietal selection that allows to capture farmers’ traditional knowledge in a fully quantitative framework and inform breeding decisions. Our work demonstrates that cultural and natural agrobiodiversity can be leveraged together to increase the effectiveness of genomics-driven breeding toward varietal development for smallholder farming systems.
Neuropathic pain feature in cancer-induced bone pain: does it matter? a prospective observational study

Background Cancer-induced bone pain (CIBP) is considered to have both nociceptive and neuropathic components. However, the prevalence, risk factors, and impact of the neuropathic components are yet poorly understood. Methods We estimate the prevalence of neuropathic pain (NP) features in patients with CIBP at a tertiary care pain clinic setting using the Douleur Neuropathique 4 questionnaire and evaluate their associated factors and their impact after 4 weeks of treatment using the Brief Pain Inventory questionnaire and the Edmonton Symptom Assessment System. Results A total of 133 patients were recruited. The estimated prevalence of NP was 30.8% (95% confidence interval 23.6%–39.1%). Initially, the patients with NP had significantly higher average pain scores (6.00 vs. 5.05, P = 0.006), higher total interference scores (5.84 vs. 4.89, P = 0.033), and symptom distress scores (35.88 vs. 26.52, P = 0.002). After 4 weeks of treatment, patients in both groups reported significantly decreased pain intensity and improved quality of life. However, the patients with NP still reported significantly higher average pain (4.61 vs. 3.58, P = 0.048), trending toward higher total interference scores (3.52 vs. 2.99, P = 0.426), and symptom distress scores (23.30 vs. 20.77, P = 0.524). From multivariate analysis, the independent risk factors for NP were younger age, pain in the extremities, and higher average pain scores. Conclusions NP are common in patients with CIBP. These conditions negatively affect pain intensity and the patient’s quality of life before and after treatment.
REVIEW ON COMPOSITE NEGATIVE REFRACTIVE INDEXED MATERIAL WITH LEFT HANDED MAXWELL SYSTEMS

This detailed write-up reviews very nature of negative refraction vis-a-vis existing physical thoughts. Why this project is called as "Left Handed Maxwell Systems" is due to counterintuitive nature of the cross product we need to take in the Maxwell equations, to satisfy that wave vector as opposite to the Poynting vector when the dielectric permittivity and magnetic permeability are both negatives; that is giving us a media of refractive index negative. This detailed note explains these phenomena, with mathematical and possible physical explanations via thought experiment; elaborating concepts of 'backward wave', 'hidden momentum', 'negative root', and several counterintuitive topics. Though several approaches to explain these counterintuitive phenomena have been evolving, yet it is interesting if in the meta-material parlance particle-wave theory be founded! Here we give possible classical explanations to these counterintuitive phenomena and also a new explanation regarding (quantized) energy momentum, wave equation if applied to this negative indexed material: how shall they look, vis-a-vis positive indexed systems.
Multimodal imaging in Best Vitelliform Macular Dystrophy: Literature review and novel insights

Best Vitelliform Macular Dystrophy (BVMD) is a dominantly inherited retinal disease caused by dominant variants in the BEST1 gene. The original classification of BVMD is based on biomicroscopy and color fundus photography (CFP); however, advancements in retinal imaging provided unique structural, vascular, and functional data and novel insights on disease pathogenesis. Quantitative fundus autofluorescence studies informed us that lipofuscin accumulation, the hallmark of BVMD, is unlikely to be a primary effect of the genetic defect. It could be due to a lack of apposition between photoreceptors and retinal pigment epithelium in the macula with subsequent accumulation of shed outer segments over time. Optical Coherence Tomography (OCT) and adaptive optics imaging revealed that vitelliform lesions are characterized by progressive changes in the cone mosaic corresponding to a thinning of the outer nuclear layer and then disruption of the ellipsoid zone, which are associated with a decreased sensitivity and visual acuity. Therefore, an OCT staging system based on lesion composition, thus reflecting disease evolution, has been recently developed. Lastly, the emerging role of OCT Angiography proved a greater prevalence of macular neovascularization, the majority of which are non-exudative and develop in late disease stages. In conclusion, effective diagnosis, staging, and clinical management of BVMD will likely require a deep understanding of the multimodal imaging features of this disease.
Optical Interconnection For Multiprocessor Computer Bus Systems

The drastically reduced costs and improved performance of fiber optic components in recent years offers an opportunity to economically incorporate high-bandwidth optical communication links within a large-scale multiprocessor system. In this paper, the design, implementation, and initial performance of a fiber optic bus for a tightly coupled multiprocessor system are discussed. This optical bus ulitizes a multiple fiber-multiple star configuration with data rates of up to 80 MHz. It transmits bus control line information by repetitively scanning the control lines and transmitting their states as a packet of bits. It is currently being used for a 30-processor system called the Heidelberg Polyp, which has a custom bus design. However, the design approach is a general one that could easily be adapted to other buses, especially asynchronous buses such as the VME bus.
A unified model of drag force for bubble-propelled catalytic micro/nano-motors with different geometries in low Reynolds number flows

Motion of catalytic micro/nano-motors with various geometries is mainly determined by the drag force and the propulsion force acting on the motors as they move in low Reynolds number flows. A unified solution of drag force along with drag coefficient for all circular cross-sectional types of micro/nano-motors is derived. The effect of the geometric parameters of a micro/nano-motor, such as the semi-cone angle θ, the ratio ξ of length to larger radius, on the drag coefficient is identified. Results provided in this work are useful for optimizing the design and fabrication of catalytic micro/nano-motors, which can be potentially used in biomedical and environmental engineering.
Practical strategies for the prevention and management of chronic postsurgical pain

Chronic postsurgical pain (CPSP) is a multifactorial condition that affects a significant proportion of patients undergoing surgery. The prevention and management of CPSP require the identification of preoperative risk factors to screen high-risk patients and establish appropriate perioperative pain management plans to prevent its development. Active postoperative pain management should be provided to prevent CPSP in patients with severe pain following surgery. These tasks have become important for perioperative team members in the management of CPSP. This review article provides a comprehensive overview of the latest research on the role of perioperative team members in preventing and managing CPSP. Additionally, it highlights practical strategies that can be employed in clinical practice, covering the definition and risk factors for CPSP, including preoperative, intraoperative, and postoperative factors, as well as a risk prediction model. The article also explores various treatments for CPSP, as well as preventive measures, including preemptive analgesia, regional anesthesia, pharmacological interventions, psychoeducational support, and surgical technique modification. This article emphasizes the importance of a comprehensive perioperative pain management plan that includes multidisciplinary interventions, using the transitional pain service as an example. By adopting a multidisciplinary and collaborative approach, perioperative team members can improve patient outcomes, enhance patient satisfaction, and reduce healthcare costs. However, further research is necessary to establish targeted interventions to effectively prevent and manage CPSP.
Local tissue mechanics control cardiac pacemaker cell embryonic patterning

Microenvironmental patterning during sinoatrial node morphogenesis is critical for sustaining cardiac pacemaker cell function. Cardiac pacemaker cells (CPCs) initiate the electric impulses that drive the rhythmic beating of the heart. CPCs reside in a heterogeneous, ECM-rich microenvironment termed the sinoatrial node (SAN). Surprisingly, little is known regarding the biochemical composition or mechanical properties of the SAN, and how the unique structural characteristics present in this region of the heart influence CPC function remains poorly understood. Here, we have identified that SAN development involves the construction of a “soft” macromolecular ECM that specifically encapsulates CPCs. In addition, we demonstrate that subjecting embryonic CPCs to substrate stiffnesses higher than those measured in vivo results in loss of coherent electrical oscillation and dysregulation of the HCN4 and NCX1 ion channels required for CPC automaticity. Collectively, these data indicate that local mechanics play a critical role in maintaining the embryonic CPC function while also quantitatively defining the range of material properties that are optimal for embryonic CPC maturation.
Regulating the Wettability of Hard Carbon through Open Mesochannels for Enhanced K+ Storage.

Hard carbons are deemed as promising anode materials for high-performance potassium-ion battery, but their commercialization is still hindered by the insufficient K+ transfer kinetics and poor potassiophilicity. Herein, these issues are addressed by improving the wettability of hard carbon, which can be achieved by the introduction of open mesochannels. A series of such hollow mesoporous carbon capsules with different dimensions are synthesized, which exhibit markedly enhanced wettability with electrolyte compared to the microporous counterparts. Various characterizations confirm its effects on promoting the kinetics and potassiophilicity of as-synthesized carbons, which can be additionally improved by S-doping. As a result, the 2D mesoporous carbon anode exhibits excellent rate capability (122.2 mAh g-1 at 4 A g-1 ), high reversible capacity (396.6 mAh g-1 at 0.1 A g-1 after 200 cycles), and outstanding cycling stability (197.0 mAh g-1 at 2 A g-1 after 1400 cycles). In addition, the hollow mesoporous architecture can effectively buffer the volume expansion and thus stabilize the carbon anodes, as visualized by in situ transmission electron microscopy. This work provides new insight for enhanced K+ storage performance from the perspective of anode wettability with electrolyte, as well as a universal anode design that combines mesochannels architecture with heteroatom doping.
The Initial Myelination in the Central Nervous System

Myelination contributes not only to the rapid nerve conduction but also to axonal insulation and protection. In the central nervous system (CNS), the initial myelination features a multistep process where oligodendrocyte precursor cells undergo proliferation and migration before differentiating into mature oligodendrocytes. Mature oligodendrocytes then extend processes and wrap around axons to form the multilayered myelin sheath. These steps are tightly regulated by various cellular and molecular mechanisms, such as transcription factors (Olig family, Sox family), growth factors (PDGF, BDNF, FGF-2, IGF), chemokines/cytokines (TGF-β, IL-1β, TNFα, IL-6, IFN-γ), hormones (T3), axonal signals (PSA-NCAM, L1-CAM, LINGO-1, neural activity), and intracellular signaling pathways (Wnt/β-catenin, PI3 K/AKT/mTOR, ERK/MAPK). However, the fundamental mechanisms for initial myelination are yet to be fully elucidated. Identifying pivotal mechanisms for myelination onset, development, and repair will become the focus of future studies. This review focuses on the current understanding of how CNS myelination is initiated and also the regulatory mechanisms underlying the process.
Decentralized stabilization of fuzzy large-scale systems

A stability criterion in terms of Lyapunov's direct method is derived to guarantee the asymptotic stability of fuzzy large-scale systems. Based on this criterion and the decentralized control scheme, a set of fuzzy controllers is synthesized via the technique of parallel distributed compensation to stabilize a fuzzy large-scale system which consists of a few interconnected subsystems represented by Takagi-Sugeno fuzzy models. Finally, a numerical example with simulations is given to illustrate the results.
Starting the five steps Stomer-Cowell method by Adams-Bashforth method for the solution of the first order ordinary differential equations

We developed a five-step Stomer-Cowell method using method of interpolation and collocation of power series approximate solution to obtain non linear systems of equation which is solved for the unknown parameters to give a continuous linear multi step method. The continuous linear multi-step is evaluated at selected grid points to give discrete linear multi-step method which serve as the corrector. The predictors are developed using the same approach but it is implemented using block method which gives constant order predictors. Basic properties of the corrector viz; order zero stability; convergence and stability interval were verified. The method was tested on some numerical examples and found to give better approximation.
The Satisfaction With Care of Patients With Schizophrenia in Taiwan: A Cross-Sectional Survey of Patient-Centered Care Domains

ABSTRACT Background Pharmacological interventions combined with nonpharmacological treatments such as patient-centered care (PCC)-related activities are widely used to enhance outcomes in patients with schizophrenia. However, few studies have examined and identified the PCC factors essential to achieving better outcomes in patients with schizophrenia. Purpose This study was designed to identify the Picker-Institute-identified PCC domains associated with satisfaction and to determine which of these domains are most important in the context of schizophrenia care. Methods Data were collected using patient surveys in outpatient settings and record reviews at two hospitals in northern Taiwan between November and December 2016. PCC data were collected in five domains: (a) support of patient autonomy; (b) goal setting; (c) collaboration and integration of healthcare services; (d) information, education, and communication; and (e) emotional support. The outcome measure was patient satisfaction. The study controlled for demographic factors, including age, gender, education, occupation, marriage, and urbanization level in the respondent's area of residence. Clinical characteristics included the Clinical Global Impressions severity and improvement index scores, previous admission, previous emergency department visit, and readmission within 1 year. Methods were adopted to prevent common method variance bias. Multivariable linear regression with stepwise selection and the generalized estimating equation were used to analyze the data. Results After controlling for confounding factors, the generalized estimating equation model found only three PCC factors significantly associated with patient satisfaction, which differed slightly from the results of the multivariable linear regression. These three factors are as follows, in order of importance: information, education, and communication (parameter = 0.65 [0.37, 0.92], p < .001); emotional support (parameter = 0.52 [0.22, 0.81], p < .001); and goal setting (parameter = 0.31 [0.10, 0.51], p = .004). Conclusions The three critical PCC-related factors were evaluated in terms of enhancing patient satisfaction in patients with schizophrenia. Practicable strategies related to these three factors should also be developed for implementation in clinical settings.
Radiation of waves by a cylinder submerged in water with ice floe or polynya

The problems of radiation (sway, heave and roll) of surface and flexural-gravity waves by a submerged cylinder are investigated for two configurations, concerning; (i) a freely floating finite elastic plate modelling an ice floe, and (ii) two semi-infinite elastic plates separated by a region of open water (polynya). The fluid of finite depth is assumed to be inviscid, incompressible and homogeneous. The linear two-dimensional problems are formulated within the framework of potential-flow theory. The method of mass sources distributed along the body contour is applied. The corresponding Green’s function is obtained by using matched eigenfunction expansions. The radiation load (added mass and damping coefficients) and the amplitudes of vertical displacements of the free surface and elastic plates are calculated. Reciprocity relations which demonstrate both symmetry of the radiation load coefficients and the relation of damping coefficients with the far-field form of the radiation potentials are found. It is shown that wave motion essentially depends on the position of the submerged body relative to the elastic plate edges. The results of solving the radiation problem are compared with the solution of the diffraction problem. It is noted that resonant frequencies in the radiation problem correlate with those frequencies at which the reflection coefficient in the diffraction problem has a local minimum.