Miracle-dz/UniFAR-FTUs huggingface dataset:
Dietary selenium intake and the risk of kidney stones in adults, an analysis of 2007–2018 National Health and Nutrition Examination Survey, a cross-sectional study

Purpose To evaluate the association between dietary selenium intake and the risk of kidney stones in adults. Materials and methods We performed a cross-sectional analysis using data from 2007 to 2018 National Health and Nutrition Examination Survey (NHANES). Dietary intake information of 30,184 participants was obtained using first 24-h dietary recall interview, and kidney stones were presented by a standard questionnaire. The quartile analysis, stratified analysis and non-linearity analysis were used to estimate the association between dietary selenium intake and kidney stones after an adjustment for potential confounders. Results The multiple logistic regression indicated that the fourth quantile (Q4) of dietary selenium intake had a lower risk of kidney stones than the first quantile (Q1) in Model 3 (OR 0.82, P < 0.05). The stratified analyses indicated there were statistical differences between dietary selenium intake and kidney stones among younger (age < 50) (OR 0.65, P < 0.01), male (OR 0.73, P < 0.01) and overweight/obese (BMI ≥ 25.0) (OR 0.80, P < 0.05) individuals in Model 3. The non-linear relationship was founded between dietary selenium intake and kidney stones in all participants, younger, male and overweight/obese individuals after adjusting for confounding factors. Conclusion Our study revealed an inverse relation between the level of dietary selenium intake and the risk of kidney stones for the United States population, especially for younger (age < 50), male and overweight/obese (BMI ≥ 25.0) individuals. The study provides preliminary guidance on dietary selenium intake for the prevention of kidney stones in different populations. Further studies are required to confirm our findings and clarified the biological mechanisms.
Inhibiting Cytoprotective Autophagy in Cancer Therapy: An Update on Pharmacological Small-Molecule Compounds

Autophagy is a self-degradation process in which damaged proteins and organelles are engulfed into autophagosomes for digestion and eventually recycled for cellular metabolism to maintain intracellular homeostasis. Accumulating studies have reported that autophagy has the Janus role in cancer as a tumor suppressor or an oncogenic role to promote the growth of established tumors and developing drug resistance. Importantly, cytoprotective autophagy plays a prominent role in many types of human cancers, thus inhibiting autophagy, and has been regarded as a promising therapeutic strategy for cancer therapy. Here, we focus on summarizing small-molecule compounds inhibiting the autophagy process, as well as further discuss other dual-target small-molecule compounds, combination strategies, and other strategies to improve potential cancer therapy. Therefore, these findings will shed new light on exploiting more small-molecule compounds inhibiting cytoprotective autophagy as candidate drugs for fighting human cancers in the future. Graphical Abstract
Editorial: Neural mechanisms of impulsivity and compulsivity and their clinical and therapeutic corollaries

COPYRIGHT © 2022 Tzagarakis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Editorial: Neural mechanisms of impulsivity and compulsivity and their clinical and therapeutic corollaries
“What makes this a wug?” Relations among children’s question asking, memory, and categorization of objects

Children ask many questions, but do not always receive answers to the questions they ask. We were interested in whether the act of generating questions, in the absence of an answer, is related to children’s later thinking. Two experiments examined whether children retain the questions they ask in working memory, and whether the type of questions asked relate to their categorization. Four to ten-year-old children (N = 42 in Experiment 1, N = 41 in Experiment 2) were shown 12 novel objects, asked three questions about each, and did not receive answers to their questions. Children recalled their questions in the first experiment and categorized variants of the novel objects in the second experiment. We found that children have robust working memory for their questions, indicating that these questions may relate to their subsequent thinking. Additionally, children generalize category boundaries more narrowly or broadly depending on the type of question they ask, indicating that children’s questions may reflect an underlying bias in how they think about the world. These findings suggest that future research should examine questions in the absence of answers to understand how inquiry affects children’s cognitive development.
The role of neutrophils in the dysfunction of central nervous system barriers

Leukocyte migration into the central nervous system (CNS) represents a central process in the development of neurological diseases with a detrimental inflammatory component. Infiltrating neutrophils have been detected inside the brain of patients with several neuroinflammatory disorders, including stroke, multiple sclerosis and Alzheimer’s disease. During inflammatory responses, these highly reactive innate immune cells can rapidly extravasate and release a plethora of pro-inflammatory and cytotoxic factors, potentially inducing significant collateral tissue damage. Indeed, several studies have shown that neutrophils promote blood-brain barrier damage and increased vascular permeability during neuroinflammatory diseases. Recent studies have shown that neutrophils migrate into the meninges and choroid plexus, suggesting these cells can also damage the blood-cerebrospinal fluid barrier (BCSFB). In this review, we discuss the emerging role of neutrophils in the dysfunction of brain barriers across different neuroinflammatory conditions and describe the molecular basis and cellular interplays involved in neutrophil-mediated injury of the CNS borders.
The evidence base on the environmental, economic and social outcomes of agroforestry is patchy—An evidence review map

Agroforestry is often seen as a panacea that offers multiple environmental, economic, and social benefits. However, the validity of generalized statements on agroforestry outcomes is doubtful because the evidence base is unclear. Systematic reviews and meta-analyses exist on the topic in addition to many case studies that address specific outcomes of individual agroforestry practices at different sites. However, the overall picture of available scientific evidence on agroforestry outcomes remains opaque due to the wide diversity of existing agroforestry practices, outcome indicators, and spatial locations. To clarify whether and in which areas the research landscape allows conclusions to be drawn about the potential benefits or drawbacks of agroforestry compared to other land uses, an evidence review map was created for the purpose of this study. Based on a systematic literature search and screening, 64 systematic review articles were finally identified that summarize ecological, economic, or social outcomes of at least one agroforestry practice compared to another land use as control. The thematic and spatial coverage of the systematic reviews on agroforestry outcomes is mapped to identify density and research gaps in the evidence base. Moreover, the comprehensibility of the study selection for each identified systematic review is critically assessed. The resulting evidence review map discloses a solid evidence base for environmental outcomes and productivity aspects of individual agrisilvicultural practices, as well as for agroforestry systems when considering an aggregate level. However, the outcomes of individual silvopastoral and agrosilvopastoral practices have been less studied in the literature. A global coverage at the level of individual agroforestry practices is only available for impacts on climate change mitigation. Major research gaps were identified for systematic analysis of social outcomes of all agroforestry types. The results of the evidence mapping highlight further research needs, but also urge for caution in making generalized statements about the benefits of agroforestry.
New approach for designing an underwater free-space optical communication system

Ocean observation system that involves multiple underwater vehicles and seafloor nodes plays an important role in better learning the ocean, where underwater wireless communication is mandatory for massive data interaction. Optical communication that has wide bandwidth and comprehensive working distance is the preferred method compared to acoustic and other methods. However, the presence of directionality makes the optical method difficult to use especially when the transceiver is equipped on a motive vehicle. In this study, an underwater free-space optical communication method of transmitting information is proposed. Characteristics of underwater optical transmission, as well as the photoelectric signal processing and modulation and demodulation algorithms, are studied and modeled. New approach for realizing underwater free-space optical communication is proposed and simulated. A prototype including a free-space optical transmitter and a receiver is developed; tests in different scenarios were carried out, and the results were observed: (1) by using the minimum number of LEDs, the effect of uniform lighting in space is achieved, and the transmitter coverage reaches 160°. (2) When the power of the transmitter is 10 W and the communication rate is 1 Mbps, the maximum communication distance reaches 13 m.
Application of the Haar wavelet transform to solving integral and differential equations

A survey on the use of the Haar wavelet method for solving nonlinear integral and differential equations is presented. This approach is applicable to different kinds of integral equations (Fredholm, Volterra, and integro-differential equations). Application to partial differential equations is exemplified by solving the sine-Gordon equation. All these problems are solved with the aid of collocation techniques. Computer simulation is carried out for problems the exact solution of which is known. This allows us to estimate the precision of the obtained numerical results. High accuracy of the results even in the case of a small number of collocation points is observed.
Interaction of advanced micro/nano electronics and materials with marine environment

COPYRIGHT © 2022 Pu, Zhu and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. TYPE Opinion PUBLISHED 11 August 2022 DOI 10.3389/fmars.2022. 940297
Global research trend of esophageal squamous cell carcinoma from 2012 to 2022: a bibliometric analysis

Background Esophageal cancer is currently a worldwide health problem. Esophageal squamous cell carcinoma (ESCC) is the most common pathological type of esophageal cancer, and its treatment methods and therapeutic effects are relatively limited, so it also requires the unremitting efforts of basic and clinical researchers to overcome difficulties. Bibliometric analysis can help sort out global research trends and hotspots, but no bibliometric analysis of ESCC has been reported. Therefore, we performed this study to analyze the global trends and potential hotspots of ESCC to indicate future research directions. Methods The articles related to ESCC research were collected from the WoS Core Collection SCI-EXPANDED database from 2012 to 2022. The article information was analyzed by BiblioShiny and VOSviewer. Results were presented as bar and network visualization to describe the current trend of ESCC research. This was a retrospective study evaluating data that is publicly available online and at libraries and institutional review board approval, as such, was not demanded. Results The global publication trend illustrated a strong growth in the ESCC research field (annual growth rate of 11.4%) and the citation trend increased from an average of 2.98 citations per article per year in 2012 to an average of 3.84 citations per article per year in 2019. With the corresponding author’s country, China contributed the largest number (5,063 articles). The scholars from China and USA had the most collaboration (427 times). China had the largest number of institutions conducting ESCC research. Oncotarget, Oncology Letters, and Annals of Surgical Oncology published the most articles, while Cancer Research, International Journal of Cancer, and Journal of Clinical Oncology had the most local citations. Furthermore, the clinical research hotspots involved in the treatment of ESCC and the basic research hotspots involved in tumor malignant phenotype have received the most attention in recent years. Conclusion Our study demonstrated that the research of ESCC has developed rapidly in recent years, and the academic institutions in China have played a decisive role in this field. The global research purpose is to find effective therapies against ESCC, so some emerging hotspots related to ESCC treatment, such as endoscopic therapy, chemoradiotherapy, immunotherapy, tumor microenvironment, and the epithelial-mesenchymal transition will receive more attention and develop rapidly in the future.
The genus Chrysanthemum: Phylogeny, biodiversity, phytometabolites, and chemodiversity

The ecologically and economically important genus Chrysanthemum contains around 40 species and many hybrids and cultivars. The dried capitulum of Chrysanthemum morifolium (CM) Ramat. Tzvel, i.e., Flos Chrysanthemi, is frequently used in traditional Chinese medicine (TCM) and folk medicine for at least 2,200 years. It has also been a popular tea beverage for about 2,000 years since Han Dynasty in China. However, the origin of different cultivars of CM and the phylogenetic relationship between Chrysanthemum and related Asteraceae genera are still elusive, and there is a lack of comprehensive review about the association between biodiversity and chemodiversity of Chrysanthemum. This article aims to provide a synthetic summary of the phylogeny, biodiversity, phytometabolites and chemodiversity of Chrysanthemum and related taxonomic groups, focusing on CM and its wild relatives. Based on extensive literature review and in light of the medicinal value of chrysanthemum, we give some suggestions for its relationship with some genera/species and future applications. Mining chemodiversity from biodiversity of Chrysanthemum containing subtribe Artemisiinae, as well as mining therapeutic efficacy and other utilities from chemodiversity/biodiversity, is closely related with sustainable conservation and utilization of Artemisiinae resources. There were eight main cultivars of Flos Chrysanthemi, i.e., Hangju, Boju, Gongju, Chuju, Huaiju, Jiju, Chuanju and Qiju, which differ in geographical origins and processing methods. Different CM cultivars originated from various hybridizations between multiple wild species. They mainly contained volatile oils, triterpenes, flavonoids, phenolic acids, polysaccharides, amino acids and other phytometabolites, which have the activities of antimicrobial, anti-viral, antioxidant, anti-aging, anticancer, anti-inflammatory, and closely related taxonomic groups could also be useful as food, medicine and tea. Despite some progresses, the genetic/chemical relationships among varieties, species and relevant genera have yet to be clarified; therefore, the roles of pharmacophylogeny and omics technology are highlighted.
Expression and regulation of 42Sp50 in spotted scat (Scatophagus argus)

42Sp50 is an isoform of the eukaryotic translation elongation factor 1 A (eEF1A) and is vital for fish ovarian development. Spotted scat (Scatophagus argus) is a popular marine cultured fish species in Southern Asia and China, and its artificial reproduction is complicated, with a relatively low success ratio in practice. In this study, the 42Sp50 gene was cloned from spotted scat. Tissue distribution analysis showed that 42Sp50 was mainly expressed in the ovary. qRT-PCR showed that 42Sp50 expression levels gradually decreased insignificantly in the ovaries from phase II to IV. Western blot analysis showed that 42Sp50 was highly expressed in the ovary, while it was almost undetectable in the testis. Immunohistochemistry analysis stained 42Sp50 mainly in the cytoplasm of the previtellogenic oocytes in ovaries of normal XX-female and sex-reversed XY-female. Aside from fish and amphibians, 42Sp50 was also identified in some reptile species using genomic database searching. Analyses of the transcriptome data from four different fish species (Hainan medaka (Oryzias curvinotus), silver sillago (Sillago sihama), Nile tilapia (Oreochromis niloticus), and Hong Kong catfish (Clarias fuscus)) revealed ovaries biased expression of 42Sp50 in all, similar to spotted scat. While the neighbor genes of 42Sp50 did not show ovary biased expression in the fish species analyzed. Bisulfite Sequencing PCR (BSP) results showed that the DNA methylation level of 42Sp50 promoter was low in ovaries, testes, and muscles. The luciferase reporter assay demonstrated that Dmrt4 activated 42Sp50 expression in the presence of Sf1 or Foxh1. These results suggest that 42Sp50 may be involved in regulating the early phase oocytes development of spotted scat.
Simultaneous quantitation of 17 endogenous adrenal corticosteroid hormones in human plasma by UHPLC-MS/MS and their application in congenital adrenal hyperplasia screening

Accurate investigation of adrenal hormone levels plays a vital role in pediatric endocrinology for the detection of steroid-related disorders. This study aims to develop a straightforward, sensitive UHPLC-MS/MS method to quantify 17 endogenous adrenal corticosteroid hormones in human plasma. These hormones are the main ingredients in the synthetic and metabolic pathways of adrenal corticosteroid hormones. Chromatographic separation was achieved on a C18 column before electrospray ionization triple-quadrupole mass spectrometry in multiple reaction monitoring mode with a run time of 7 min. The samples were extracted by liquid-liquid extraction and required no derivatization. Analytical performance was evaluated, including linearity, analytical sensitivity, accuracy, precision, and specificity. Plasma specimens from 32 congenital adrenal hyperplasia (CAH) patients and 30 healthy volunteers were analyzed to further reveal the diagnostic value of multiple steroid hormones in the synthetic and metabolic pathways of adrenal corticosteroid in CAH diagnosis. All hormones were effectively extracted and separated using our method. The method was essentially free from potential interference of isomers or structural analogues. The imprecisions were <10%. The lower limits of quantification varied from 0.05 to 15.0 ng/ml. Good linearity coefficients (r 2 > 0.998) were also obtained for most hormones in the required concentration range, except for 21-deoxycortisol (r 2 = 0.9967) and androstenediol (r 2 = 0.9952). The recoveries for the steroid hormones ranged from 91.7 to 109.8%. We developed the UHPLC-MS/MS method for the simultaneous measurement of steroid hormones. The results showed that measurement of steroid hormones simultaneously could improve the diagnostic efficiency of CAH.
Open Research Online Analysing the co-evolution of embedded regulatory capabilities in ﬁrms and the state: the case of South Africa’s medical device sector

Analysing the co-evolution of embedded regulatory capabilities in firms and the state: the case of South Africa’s medical device sector Conference or Workshop Item How to cite: Mkwashi, Andrew; Kale, Dinar; Mugwagwa, Julius and Wield, David (2021). Analysing the co-evolution of embedded regulatory capabilities in firms and the state: the case of South Africa’s medical device sector. In: 17th Globelics International Conference 2021, 3-5 Nov 2021, Heredia, Costa Rica.
Mutual privacy and good manners on the social web

On social media we read comments of our family, friends, acquaintances and even strangers. These comments are sometimes positive and fun to read, but sometimes they might be oﬀensive, threatening or even breaching the privacy of other people. Within this research paper, we explore implicit social norms, behaviours and privacy expectations on social networking services by trying to identify to what extent people intervene online ‘friends’ that behave undesirable and breach other people’s privacy. Also, we explore the bystander eﬀect and to what extent it inﬂuences whether people actually intervene or not. Finally, we describe a possible and very general design concept for social media, with the ultimate goal of increasing the degree to which users of social media intervene and stimulating good manners on the social web. Our research is a qualitative exploratory research in which we have conducted in-depth inter-views among users that intensively make use of social media. Within our research, we ﬁnd that deciding to intervene on social media is something very personal, as each individual has its own implicit norms and social expectations. People often intervene their online ‘friends’ using a private approach. Additionally, we ﬁnd that the severity of a privacy violation and the relationship one has with a privacy violator are two important factors inﬂuencing whether someone chooses to intervene. Besides this, we also ﬁnd that the bystander eﬀect in the way it is presented in related literature is quite limited when it comes to intervention on social networking sites. However, users do adapt their behaviour and use of language if they are aware of the presence of ‘online bystanders’.
Development characterization of SiC fiber reinforced B 4 C composite

This study is conducted to investigate the effects of silicon carbide short fiber (SiC f ) reinforcement on processing and properties of boron carbide ceramic. Studies have been carried out on the hot pressing, mechanical property measurement, microstructure evolution and oxidation study of SiC f reinforced B 4 C composite. B 4 C-SiC f composites have been prepared by hot pressing at 1950℃ with varying SiC f content in the range of 10 vol% to 30 vol%. All the composites are densified to near theoretical density. It is noticed that hardness of composite is decreased and fracture toughness of composite is increased by addition of SiC fiber. Hardness of the composites are found in the range of 32 GPa to 38 GPa. Fracture toughness of the composites are obtained to be higher than that of the monolithic boron carbide. The values are measured in the range of 4.3 MPa  m -½ to 5.1 MPa  m -½ . In microstructure evolution it is found that SiC fibers are uniformly distributed throughout the matrix. The developed B 4 C-SiC f composites have been found to have good resistance to oxidation at 800℃ in air.