Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization in Effective Stimulation on the Magnitude, Gating, Frequency Dependence, and Hysteresis of INa Exerted by Picaridin (or Icaridin), a Known Insect Repellent

Picaridin (icaridin), a member of the piperidine chemical family, is a broad-spectrum arthropod repellent. Its actions have been largely thought to be due to its interaction with odorant receptor proteins. However, to our knowledge, to what extent the presence of picaridin can modify the magnitude, gating, and/or the strength of voltage-dependent hysteresis (Hys(V)) of plasmalemmal ionic currents, such as, voltage-gated Na+ current [INa], has not been entirely explored. In GH3 pituitary tumor cells, we demonstrated that with exposure to picaridin the transient (INa(T)) and late (INa(L)) components of voltage-gated Na+ current (INa) were differentially stimulated with effective EC50’s of 32.7 and 2.8 μM, respectively. Upon cell exposure to it, the steady-state current versus voltage relationship INa(T) was shifted to more hyperpolarized potentials. Moreover, its presence caused a rightward shift in the midpoint for the steady-state inactivate curve of the current. The cumulative inhibition of INa(T) induced during repetitive stimuli became retarded during its exposure. The recovery time course from the INa block elicited, following the conditioning pulse stimulation, was satisfactorily fitted by two exponential processes. Moreover, the fast and slow time constants of recovery from the INa block by the same conditioning protocol were noticeably increased in the presence of picaridin. However, the fraction in fast or slow component of recovery time course was, respectively, increased or decreased with an increase in picaridin concentrations. The Hys(V)’s strength of persistent INa (INa(P)), responding to triangular ramp voltage, was also enhanced during cell exposure to picaridin. The magnitude of resurgent INa (INa(R)) was raised in its presence. Picaritin-induced increases of INa(P) or INa(R) intrinsically in GH3 cells could be attenuated by further addition of ranolazine. The predictions of molecular docking also disclosed that there are possible interactions of the picaridin molecule with the hNaV1.7 channel. Taken literally, the stimulation of INa exerted by the exposure to picaridin is expected to exert impacts on the functional activities residing in electrically excitable cells.
IOT FRAME-WORK FOR ENERGY EFFICIENT SMART BUILDING

Internet of Things (IOT) is a vision towards Future Internet where “things” are provided with enough intelligence to communicate with each other without the human intervention. With the proliferation of Internet of Things (iot) Devices such as smart phones, sensors, cameras, and RFID etc. It is possible to collect massive amount of data for localization and tracking of people within commercial buildings. This proposed occupancy monitoring develop effective data fusion techniques for improving occupancy monitoring accuracy using a multitude of sources for the occupancy collection of data, IR sensors are used for the detection of existence of the persons and it will count the people in the buildings entering .
Comparison of Extracorporeal Shock Wave Therapy and Ultrasound-Guided Shoulder Injection Therapy in Patients with Supraspinatus Tendinitis

Background The present study compared the clinical effect of extracorporeal shock wave therapy (ESWT) with that of ultrasound (US)-guided shoulder steroid injection therapy in patients with supraspinatus tendinitis. We hypothesized that the two treatments would show comparable results. Methods The inclusion criteria were age over 20 years and diagnosis of supraspinatus tendinitis using US. Ultimately, 26 patients were assigned using blocked randomization: 13 in the US-guided shoulder injection group and 13 in the ESWT group. Treatment outcomes were evaluated using the pain visual analog scale (pVAS), the American Shoulder and Elbow Society (ASES) score, and the Constant score at baseline and at 1 and 3 months after the procedure. Results At 1 month after the intervention, pVAS, ASES, and constant score were significantly higher in the US-guided shoulder injection group than in the ESWT group, but not at 3 months after the intervention. Both groups showed clinically significant treatment effects at 3 months after the intervention compared to baseline. No significance was shown using equivalence testing. Conclusions US-guided shoulder injection therapy was not superior to ESWT therapy. Considering the complications and rebound phenomenon of steroid injections, interventions using ESWT may be a good alternative to treat patients with supraspinatus tendinitis.
Iterative quantum optimization with an adaptive problem Hamiltonian for the shortest vector problem

Quantum optimization algorithms hold the promise of solving classically hard, discrete optimization problems in practice. The requirement of encoding such problems in a Hamiltonian realized with a finite -- and currently small -- number of qubits, however, poses the risk of finding only the optimum within the restricted space supported by this Hamiltonian. We describe an iterative algorithm in which a solution obtained with such a restricted problem Hamiltonian is used to define a new problem Hamiltonian that is better suited than the previous one. In numerical examples of the shortest vector problem, we show that the algorithm with a sequence of improved problem Hamiltonians converges to the desired solution.
Composition and reactivity of volatile organic compounds in the South Coast Air Basin and San Joaquin Valley of California

Abstract. Comprehensive aircraft measurements of volatile organic compounds (VOCs) covering the South Coast Air Basin (SoCAB) and San Joaquin Valley (SJV) of California were obtained in the summer of 2019. Combined with the CO, CH4, and NOx data, the total calculated gas-phase hydroxyl radical reactivity (cOHRTOTAL) was quantified to be 6.1 and 4.6 s−1 for the SoCAB and SJV, respectively. VOCs accounted for ∼ 60 %–70 % of the cOHRTOTAL in both basins. In particular, oxygenated VOCs (OVOCs) contributed >60 % of the cOHR of total VOCs (cOHRVOC) and the total observed VOC mixing ratio. Primary biogenic VOCs (BVOCs) represented a minor fraction (<2 %) of the total VOC mixing ratio but accounted for 21 % and 6 % of the cOHRVOC in the SoCAB and SJV, respectively. Furthermore, the contribution of BVOCs to the cOHRVOC increased with increasing cOHRVOC in the SoCAB, suggesting that BVOCs were important ozone precursors during high ozone episodes. Spatially, the trace gases were heterogeneously distributed in the SoCAB, with their mixing ratios and cOHR being significantly greater over the inland regions than the coast, while their levels were more evenly distributed in SJV. The results highlight that a better grasp of the emission rates and sources of OVOCs and BVOCs is essential for a predictive understanding of the ozone abundance and distribution in California.
Association between Chronological Age and IGF-1, IGFBP-3, and CTX Levels in Saliva of Children through Younger Adult Population with Varying Periodontal Status

The quest for the most precise and non-invasive technology to monitor the pubertal growth spurt is driven by the role of growth determination in orthodontics. The objective of this study was to estimate the levels of salivary insulin-like growth factor-1 (IGF-1), IGF-binding protein-3 (IGFBP-3), and cross-linked C-terminal telopeptide of type I collagen (CTX1), and to analyze whether the levels of these biomarkers vary among different chronological age groups with and without periodontal disease. Eighty participants were divided into three groups based on their chronological age: group 1: 6–12 years; group 2: 13–19 years; and group 3: 20–30 years. The assessed clinical parameters included the simplified oral hygiene index (OHI-S), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment loss (CAL), and community periodontal index (CPI). Using ELISA kits, the IGF-1, IGFBP-3, and CTX1 levels in the saliva samples were estimated. The salivary concentration of IGFBP-3 was significantly associated with age and gender (p < 0.01). However, no significance was observed between subjects with and without periodontal disease. Significant associations existed between the values of IGF-1, IGFBP-3, and CTX1 in saliva among subjects from the various chronological age groups. Estimation of salivary IGF-1 and IGFBP-3 could serve as a useful tool in the assessment of growth maturity and bone remodeling patterns during orthodontic treatment planning.
Efficacy and Safety of Plazomicin in the Treatment of Enterobacterales Infections: A Meta-analysis of Randomized Controlled Trials

Abstract Background In the present study, we aimed to compare the efficacy and safety of plazomicin with comparators for the treatment of Enterobacterales infections. Methods Randomized controlled trials (RCTs) assessing plazomicin for Enterobacterales infections were searched on the PubMed, Embase, and Cochrane Library databases. Meta-analyses were used to evaluate the efficacy and safety in RCTs. Results A total of 3 RCTs consisting of 761 patients were included in the present analysis. The study population included complex urinary tract infections (cUTIs), bloodstream infections (BSIs), and hospital-acquired pneumonia (HAP). Plazomicin had a clinical remission rate in the modified intention-to-treat (MITT) population that was similar to that of comparators (odds ratio [OR], 1.02; 95% CI, 0.60–1.73; I2 = 45%) in the pooled analysis of the 3 studies. The overall microbiologic eradication rate in the microbiological MITT (mMITT) population was similar to that of the comparators group (OR, 1.46; 95% CI, 0.72–2.95; I2 = 0%). However, the microbiologic recurrence rate of plazomicin for Enterobacterales was lower than that in the comparators group (OR, 0.38; 95% CI, 0.17–0.86; P = .02; I2 = 0%). No signiﬁcant differences were found between plazomicin and comparators for the risk of any adverse events (OR, 0.78; 95% CI, 0.55–1.11; I2 = 0%). Conclusions Plazomicin is as good as comparators in terms of efficacy and tolerance in the treatment of Enterobacterales infections. Therefore, plazomicin is a suitable choice for antibiotic treatment in adult patients with cUTIs, BSIs, or HAP.
Evaluation and Management of Hypoparathyroidism Summary Statement and Guidelines from the Second International Workshop

This clinical practice guideline addresses the prevention, diagnosis, and management of hypoparathyroidism (HypoPT) and provides evidence‐based recommendations. The HypoPT task forces included four teams with a total of 50 international experts including representatives from the sponsoring societies. A methodologist (GG) and his team supported the taskforces and conducted the systematic reviews. A formal process following the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology and the systematic reviews provided the structure for seven of the guideline recommendations. The task force used a less structured approach based on narrative reviews for 20 non‐GRADEd recommendations. Clinicians may consider postsurgical HypoPT permanent if it persists for >12 months after surgery. To predict which patients will not develop permanent postsurgical HypoPT, we recommend evaluating serum PTH within 12 to 24 hours post total thyroidectomy (strong recommendation, moderate quality evidence). PTH > 10 pg/mL (1.05 pmol/L) virtually excludes long‐term HypoPT. In individuals with nonsurgical HypoPT, genetic testing may be helpful in the presence of a positive family history of nonsurgical HypoPT, in the presence of syndromic features, or in individuals younger than 40 years. HypoPT can be associated with complications, including nephrocalcinosis, nephrolithiasis, renal insufficiency, cataracts, seizures, cardiac arrhythmias, ischemic heart disease, depression, and an increased risk of infection. Minimizing complications of HypoPT requires careful evaluation and close monitoring of laboratory indices. In patients with chronic HypoPT, the panel suggests conventional therapy with calcium and active vitamin D metabolites as first‐line therapy (weak recommendation, low‐quality evidence). When conventional therapy is deemed unsatisfactory, the panel considers the use of PTH. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
γ-Radiation Enhanced Luminescence of Thiol-Capped Quantum Dots in Aqueous Solution

Quantum dots (QDs) have attracted great attention due to their unique optical properties. High fluorescence efficiency is very important for their practical application. In this study, we report a simple and efficient strategy to enhance the photoluminescence of water-dispersed thiol-capped QDs using γ-radiation. Three kinds of QDs with different surface ligands and cores (MPA-CdTe, MPA-CdSe and Cys-CdTe) were fabricated and irradiated by high-energy γ-ray in an aqueous solution. Their photoluminescence intensities were significantly enhanced after irradiation, which were closely related to the radiation dose and the structure of QDs. The positions of the fluorescence emission peaks did not shift obviously after irradiation. The mechanism of photoluminescence enhancement was discussed based on the results of photoluminescence (PL) spectra, UV-visible light absorption (UV-vis) spectra, transmission electron microscope (TEM), X-ray diffraction (XRD) patterns, Fourier transform infrared (FT-IR) spectra and X-ray photoelectron spectroscopy (XPS). This method can be employed to uniformly treat large batches of QDs at room temperature and without other chemicals.
The Role of Transcription Factor PPAR-γ in the Pathogenesis of Psoriasis, Skin Cells, and Immune Cells

The peroxisome proliferator-activated receptor PPAR-γ is one of three PPAR nuclear receptors that act as ligand-activated transcription factors. In immune cells, the skin, and other organs, PPAR-γ regulates lipid, glucose, and amino acid metabolism. The receptor translates nutritional, pharmacological, and metabolic stimuli into the changes in gene expression. The activation of PPAR-γ promotes cell differentiation, reduces the proliferation rate, and modulates the immune response. In the skin, PPARs also contribute to the functioning of the skin barrier. Since we know that the route from identification to the registration of drugs is long and expensive, PPAR-γ agonists already approved for other diseases may also represent a high interest for psoriasis. In this review, we discuss the role of PPAR-γ in the activation, differentiation, and proliferation of skin and immune cells affected by psoriasis and in contributing to the pathogenesis of the disease. We also evaluate whether the agonists of PPAR-γ may become one of the therapeutic options to suppress the inflammatory response in lesional psoriatic skin and decrease the influence of comorbidities associated with psoriasis.
A Comparative Analysis of the Core Proteomes within and among the Bacillus subtilis and Bacillus cereus Evolutionary Groups Reveals the Patterns of Lineage- and Species-Specific Adaptations

By integrating phylogenomic and comparative analyses of 1104 high-quality genome sequences, we identify the core proteins and the lineage-specific fingerprint proteins of the various evolutionary clusters (clades/groups/species) of the Bacillus genus. As fingerprints, we denote those core proteins of a certain lineage that are present only in that particular lineage and absent in any other Bacillus lineage. Thus, these lineage-specific fingerprints are expected to be involved in particular adaptations of that lineage. Intriguingly, with a few notable exceptions, the majority of the Bacillus species demonstrate a rather low number of species-specific fingerprints, with the majority of them being of unknown function. Therefore, species-specific adaptations are mostly attributed to highly unstable (in evolutionary terms) accessory proteomes and possibly to changes at the gene regulation level. A series of comparative analyses consistently demonstrated that the progenitor of the Cereus Clade underwent an extensive genomic expansion of chromosomal protein-coding genes. In addition, the majority (76–82%) of the B. subtilis proteins that are essential or play a significant role in sporulation have close homologs in most species of both the Subtilis and the Cereus Clades. Finally, the identification of lineage-specific fingerprints by this study may allow for the future development of highly specific vaccines, therapeutic molecules, or rapid and low-cost molecular tests for species identification.
E-commerce Platform Based on Multi-distribution Pattern

Since the popularity of the Internet has brought a vast Market for e-commerce, the prevalence of social network integrates e-commerce into everyday life well and make the idea that everyone is the seller and everyone can do business come true. How to make the traditional e-commerce platform support the pattern based on the social network is a matter of great urgency. In order to adapt to the social network, this paper designs and implements an e-commerce platform based on multilevel distribution.
A Novel Beam Alignment Scheme for Mobile Millimeter-Wave Communications Based on Compressed Sensing Aided-Kalman Filter

In millimeter wave (mmWave) communications, fast and reliable beam alignment is crucial to the achievable data rate. The problem is even more challenging when either the transmitter or the receiver, or both move that need timely update of the best beam pair. Some existing work tracks the channel changes by Kalman filter (KF). Alternatively, compressed sensing (CS) approaches are useful to reconstruct the channel based on the sparsity of mmWave channels. However, the aforementioned methods either need a full scan over all possible beam pairs or require frequent beam training, leading to high overhead. In this paper, a novel beam alignment scheme based on an integrated KF and CS framework is proposed for the single-user mmWave channel. Since the CS performance is heavily dependent on the sparsity level, the proposed method increases the signal sparsity level by applying adaptive CS on the observation residual computed from the previous estimate of the support to predict the angles of the dominant paths, while the corresponding path gains are tracked by the reduced-order KF. To further exploit the spatial correlation of sparse signals, our approach considers the adaptation of the sensing matrix based on the previous estimate to enhance the estimation accuracy, and the weighted CS is adopted for shrinking the possible range of solutions. To balance the estimation accuracy and alignment overhead, a switching mechanism is proposed that determines the timing for switching the estimation policy between beam training and beam tracking. Simulations are performed to evaluate the performance of the proposed method subject to numerous important factors, such as signal-to-noise ratio (SNR), number of available beams, overhead for beam alignment, beam variation rate, and the dominance of line-of-sight path.
Enhancing Classification in Zero-Shot Learning with the Aid of Perceptron

Since it is costly to obtain labeled instances for each class, and new classes emerge over time, there are no instances in training set for some classes in image classification. These classes are called test classes and to classify them, Zero-Shot Learning (ZSL) was developed. However, ZSL makes use of training classes to classify the test classes, which raises the domain shift problem. To deal with the domain shift problem, a new algorithm called PPG was developed in this study, which has its roots in the perceptron algorithm. PPG is able to update the prototypes of the test classes considering the transfer matrix learned using the training classes. By integrating PPG into the state-of-the-art ZSL methods, a better classification of the test classes was achieved.
The Impact of Store Image and Store Satisfaction in Determining Consumers’ Loyalty toward Convenience Stores in Indonesia

This research was conducted to assess and determine how both store image and store satisfaction could affect people’s or consumers’ level of loyalty toward convenience stores in Indonesia, particularly during the current COVID-19 pandemic which had inadvertently made the business environment in Indonesia to be full of uncertainty. The convenience sampling method was chosen to be implemented in this study to ensure that all respondents who participated in this study had satisfied and conformed with the criteria of the respondents set in this study, in which, respondents should be those who live in Indonesia who’ve purchased any kind of products at least 5 times from any convenience stores located within the Jabodetabek area for the past 6 months. Moreover, using questionnaires to obtain all of the data required from the respondents, a total of 250 respondents participated in this study, in which, a total of 227 data had been deemed valid and usable, thus confirming these 227 data will be further analyzed in this study using PLS-SEM method to determine the relationships between variables assessed and discussed in this study. After thoroughly examining and analyzing all of these dataPenelitian ini dilakukan guna menentukan bagaimana pengaruh yang diberikan oleh store image dan store satisfaction terhadap tingkat loyalitas konsumen terhadap sektor ritel minimarket (convenience stores) di Indonesia, terutama di masa pandemi COVID-19 yang secara tidak langsung telah membuat dunia ataupun sektor bisnis di Indonesia menjadi penuh dengan ketidakpastian. Adapun convenience sampling dipilih sebagai metode sampling pada studi ini guna memastikan bahwa memang seluruh responden yang berpartisipasi pada penelitian ini telah memenuhi seluruh persyaratan ataupun kriteria responden yang telah ditetapkan, yang dimana seluruh responden adalah warga Indonesia yang pernah berbelanja di minimarket apapun di daerah Jabodetabek minimal 5 kali dalam kurun waktu 6 bulan terakhir. Adapun kuesioner digunakan pada penelitian ini, yang dimana dari sebanyak 250 kuesioner yang disebarkan kepada responden, sebanyak 227 data dinyatakan valid serta dapat digunakan untuk dianalisis secara lebih lanjut pada penelitian ini. Adapun setelah menganalisis seluruh data dengan menggunakan metode PLS-SEM, peneliti dapat menyimpulkan bahwa store image dan store satisfaction berperan positif dan signifikan di dalam memengaruhi tingkat loyalitas dari konsumen pada sektor minimarket yang ada di Indonesia. , the researchers would like to conclude that both store image and store satisfaction were found as two variables that positively and significantly affected consumers’ level and state of loyalty toward convenience stores in Indonesia during the current COVID-19 pandemic.