Miracle-dz/UniFAR-FTUs huggingface dataset:
Overexpression of AHL proteins enhances root hair production by altering the transcription of RHD6‐downstream genes

Abstract AT‐HOOK MOTIF NUCLEAR LOCALIZED (AHL) proteins occur in all sequenced plant species. They bind to the AT‐rich DNA sequences in chromosomes and regulate gene transcription related to diverse biological processes. However, the molecular mechanism underlying how AHL proteins regulate gene transcription is poorly understood. In this research, we used root hair production as a readout to study the function of two Arabidopsis AHL proteins, AHL17, and its closest homolog AHL28. Overexpression of AHL17 or AHL28 greatly enhanced root hair production by increasing the transcription of an array of genes downstream of RHD6. RHD6 is a key transcription factor that regulates root hair development. Mutation of RHD6 completely suppressed the overproduction of root hairs by blocking the transcription of AHL17‐activated genes. The overexpression of AHL17 or AHL28, however, neither affected the transcription of RHD6 nor the accumulation of RHD6 protein. These two AHL proteins also did not directly interact with RHD6. Furthermore, we found that three members of the Heat Shock Protein70 family, which have been annotated as the subunits of the plant Mediator complex, could form a complex with both AHL17 and RHD6. Our research might reveal a previously unrecognized mechanism of how AHL proteins regulate gene transcription.
Visual Image Sequential Motion Detection via Half Quadratic Minimization Method

In this paper, we present a straightforward numerical algorithm for visual image sequential motion detection based on half quadratic minimization method. As for the standard visual image sequences with RGB color representation, an intuitive way is to convert it to grayscale image to achieve an approximate motion detection with relatively low computational load. Instead, we propose a sequential processing scheme for more accurate detection by utilizing the motion detection algorithm separately and then performing fusion on a higher level. In this way, we extend the motion detection technique for grayscale images to be capable of dealing with visual videos. Experiment results show that the proposed algorithm can provide more robust motion detection performance and be successfully utilized in practical visual surveillance applications.
Influence of palm kernel cake on the growth performance, gut health and hematochemical indices of slow-growing broilers

ABSTRACT Four hundred and fifty (450) 3-week-old male and female broiler chicks were randomly allocated to a control diet and four dietary treatments with six replicates in a completely randomized design (CRD) with 15 birds per replicate arranged in a 2 × 2 factorial design to evaluate the effect of palm kernel cake (PKC) diet and multi-blend enzymes on the performance of Sasso broilers. The five dietary treatments were T0 = (control, standard diet), T1 = PKC1*0% (10% PKC with no enzyme), T2 = PKC1*0.05% (10% PKC with enzyme), T3 = PKC2*0% (20% PKC with no enzyme) and T4 = PKC2*0.05% (20% PKC with enzyme). The interactive effect of PKC and enzyme showed improved (p < 0.05) FCR in T1 and T2. Higher counts (p < 0.05) of Lactobacillus spp. were found in PKC2 than in PKC1 and lower Clostridium perfringens counts in T3 compared to T2 at 8 weeks. At week 12, the PKC-enzyme effect resulted in higher (p < 0.05) platelets in the T2 and T4 groups than in the other treatments. The incorporation of 10% PKC with enzyme into the diets of Sasso broilers could maintain bacteria balance in their gut and enhance growth performance.
Blow-up solutions for fully nonlinear equations: Existence, asymptotic estimates and uniqueness

Abstract The primary objective of the paper is to study the existence, asymptotic boundary estimates and uniqueness of large solutions to fully nonlinear equations H ⁢ ( x , u , D ⁢ u , D 2 ⁢ u ) = f ⁢ ( u ) + h ⁢ ( x ) {H(x,u,Du,D^{2}u)=f(u)+h(x)} in bounded C 2 {C^{2}} domains Ω ⊆ ℝ n {\Omega\subseteq\mathbb{R}^{n}} . Here H is a fully nonlinear uniformly elliptic differential operator, f is a non-decreasing function that satisfies appropriate growth conditions at infinity, and h is a continuous function on Ω that could be unbounded either from above or from below. The results contained herein provide substantial generalizations and improvements of results known in the literature.
Runlength-Limited Sequences and Shift-Correcting Codes

This work is motivated by the problem of error correction in bit-shift channels with the so-called $ (d,k) $ input constraints (where successive $ 1 $'s are required to be separated by at least $ d $ and at most $ k $ zeros, $ 0 \leq d < k \leq \infty $). Bounds on the size of optimal $ (d,k) $-constrained codes correcting a fixed number of bit-shifts are derived. The upper bound is obtained by a packing argument, while the lower bound follows from a construction based on a family of integer lattices. Several properties of $ (d, k) $-constrained sequences that may be of independent interest are established as well; in particular, the capacity of the noiseless channel with $ (d, k) $-constrained constant-weight inputs is characterized. The results are relevant for magnetic and optical storage systems, reader-to-tag RFID channels, and other communication models where bit-shift errors are dominant and where $ (d, k) $-constrained sequences are used for modulation.
Умножение классов сопряженности, операторные узлы и характеристические функции матричного аргумента@@@

We extend the classical construction of operator colligations and characteristic functions. Consider the group $G$ of finite block unitary matrices of size $\alpha+\infty+. +\infty$ ($k$ times). Consider the subgroup $K=U(\infty)$, which consists of block diagonal unitary matrices (with a block 1 of size $\alpha$ and a matrix $u\in U(\infty)$ repeated $k$ times). It appears that there is a natural multiplication on the conjugacy classes $G//K$. We construct 'spectral data' of conjugacy classes, which visualize the multiplication and are sufficient for a reconstruction of a conjugacy class.
Brown-Teitelboim instantons and thermodynamics of de Sitter and anti–de Sitter space

We study the instantons (or bounces) in the Brown-Teitelboim (BT) mechanism of relaxation of cosmological constant which is a cosmological version of the Schwinger mechanism. The BT mechanism is a false vacuum decay of (A)dS$_{d+1}$ (and $R^{1, d}$) spaces via spontaneous nucleations of spherical $(d-1)$-branes and thus ostensibly has bearings on (A)dS$_{d+1}$/CFT$_d$ holography. In this paper we focus on the four-dimensional case, although the higher or lower-dimensional generalization is straightforward. As is the case with pair productions near black hole and de Sitter horizons, we show that the BT instanton action for a membrane nucleation encodes the first law of thermodynamics of (Anti) de Sitter space. In particular, the membrane instanton precisely accounts for the change of entropy of (A)dS space before and after nucleation, in good accordance with AdS$_{d+1}$/CFT$_d$ in which the $(d-1)$-branes make up all degrees of freedom of AdS$_{d+1}$ space. In light of this lesser-known perspective presented here we also make remarks on (1) (A)dS/CFT and (2) complexity. For the complexity we observe that the Lorentzian bounce action may have close connection to complexity.
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

BACKGROUND Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in which the risk of disease is influenced by complex genetic and environmental contributions. Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong evidence for the existence of additional risk loci. METHODS We genotyped more than 500,000 single-nucleotide polymorphisms (SNPs) in DNA samples from 1311 case subjects with SLE and 1783 control subjects; all subjects were North Americans of European descent. Genotypes from 1557 additional control subjects were obtained from public data repositories. We measured the association between the SNPs and SLE after applying strict quality-control filters to reduce technical artifacts and to correct for the presence of population stratification. Replication of the top loci was performed in 793 case subjects and 857 control subjects from Sweden. RESULTS Genetic variation in the region upstream from the transcription initiation site of the gene encoding B lymphoid tyrosine kinase (BLK) and C8orf13 (chromosome 8p23.1) was associated with disease risk in both the U.S. and Swedish case-control series (rs13277113; odds ratio, 1.39; P=1x10(-10)) and also with altered levels of messenger RNA in B-cell lines. In addition, variants on chromosome 16p11.22, near the genes encoding integrin alpha M (ITGAM, or CD11b) and integrin alpha X (ITGAX), were associated with SLE in the combined sample (rs11574637; odds ratio, 1.33; P=3x10(-11)). CONCLUSIONS We identified and then confirmed through replication two new genetic loci for SLE: a promoter-region allele associated with reduced expression of BLK and increased expression of C8orf13 and variants in the ITGAM-ITGAX region.
A IMPLEMENTAÇÃO DA TECNOLOGIA BLOCKCHAIN NOS MODELOS REGISTRAIS IMOBILIÁRIOS: O MODELO DE TÍTULO NORTE-AMERICANO E O MODELO DE DIREITOS BRASILEIRO SOB A PERSPECTIVA DA ANÁLISE ECONÔMICA DO DIREITO

Com os avanços das tecnologias e as transformações que elas sugerem no mercado, o presente artigo tem o intuito de abordar os modelos registrais imobiliários norte-americano e brasileiro, respectivamente, o registro de documentos e o registro de direitos. Nesse sentido, são apresentadas as características e conformações desses modelos, tanto no aspecto de proteção do terceiro adquirente quanto no modo de transmissão da propriedade. Posteriormente, vislumbra-se o impacto que a tecnologia blockchain terá frente a esses modelos registrais, questionando o seu ideal disruptivo ou meramente auxiliar. Ademais, são apresentados os reflexos que a inserção da rede blockchain trará em cada modelo, discutindo-se a sua viabilidade diante dos modelos registrais com características diametralmente opostas. Por fim, busca-se analisar a introdução da blockchain nos modelos registrais sob à ótica da Análise Econômica do Direito, concluindo-se que a depender do modelo utilizado a blockchain pode auxiliar ou não como um redutor das falhas de mercado.
Potential release of trace metal ions from metallic orthodontic appliances and dental metal implants: A Review of in vitro and in vivo experimental studies

Metallic wear nanoparticles, corrosion products and trace metal ions release from metallic materials, e.g. metallic alloys and pure metals, implanted into the human and animal's body in orthodontic surgery is becoming a major cause for concern. Additionally, metallic wear nanoparticles can themselves undergo a corrosion process contributing to the total level of dissolved metal ions. This review briefly provides an overview of both metallic alloys and pure metals used in implant materials in dental surgery. A short section is dedicated to important biomaterials and their corrosive behavior in both real solutions and various types of media that model human and animal's biological fluids and tissues. The present review gives an overview of analytical methods, techniques and different approaches applied to the measurement of in vivo and in vitro trace metals released into body fluids and tissues from patients and animals carrying metal dental implants and metallic orthodontic appliances. Reference levels of ion concentrations in body fluids and tissues that have been determined by a host of studies are compiled, reviewed and presented in this paper. This review summarizes data, describing the potential toxicity of metal wear debris, free metallic ions and corrosion products release from metallic orthodontic appliances (metal surgical implants) in vivo and in vitro. Finally, a collection of published clinical data on in vivo and in vitro released trace metals from metal dental implants is included.
BRIEF REVIEW ON PROPHYLAXIS AND TREATMENT OF CARIES DISEASE.

Nilviane Pereira Dias 1 , Thaysa Moreira Vasconcelos 1 , Lorena Trivilin Menezes 1 , Leandro Moreira Tempest 1,2 , Idiberto José Zotarelli Filho 2 and Simone Andreia Gubolin 1,2 . 1. University Center North Paulista (Unorp) São José do Rio Preto – SP, Brazil. 2. Post graduate and continuing education (Unipos), Street Ipiranga, 3460, São José do Rio Preto SP, Brazil 15020-040. Manuscript Info Abstract . Manuscript History
The Nitsche phenomenon for weighted Dirichlet energy

Abstract The present paper arose from recent studies of energy-minimal deformations of planar domains. We are concerned with the Dirichlet energy. In general the minimal mappings need not be homeomorphisms. In fact, a part of the domain near its boundary may collapse into the boundary of the target domain. In mathematical models of nonlinear elasticity this is interpreted as interpenetration of matter. We call such occurrence the Nitsche phenomenon, after Nitsche’s remarkable conjecture (now a theorem) about existence of harmonic homeomorphisms between annuli. Indeed the round annuli proved to be perfect choices to grasp the nuances of the problem. Several papers are devoted to a study of deformations of annuli. Because of rotational symmetry it seems likely that the Dirichlet energy-minimal deformations are radial maps. That is why we confine ourselves to radial minimal mappings. The novelty lies in the presence of a weight in the Dirichlet integral. We observe the Nitsche phenomenon in this case as well, see our main results Theorem 1.4 and Theorem 1.7. However, the arguments require further considerations and new ingredients. One must overcome the inherent difficulties arising from discontinuity of the weight. The Lagrange–Euler equation is unavailable, because the outer variation violates the principle of none interpenetration of matter. Inner variation, on the other hand, leads to an equation that involves the derivative of the weight. But our weight function is only measurable which is the main challenge of the present paper.
Hierarchical porous zeolitic imidazolate frameworks (ZIF-8) and ZnO@N-doped carbon for selective adsorption and photocatalytic degradation of organic pollutants

Removing organic contaminants such as dyes from water is essential to purify wastewater. Herein, zeolitic imidazolate framework-8 (ZIF-8) and ZnO@N-doped C are reported as effective adsorbents and photocatalysts for the adsorption and degradation of organic dyes. The materials showed effective and selective adsorption toward anionic dyes such as methyl blue (MeB) dye in the presence of fluorescein (FLU) dye. The adsorption capacities of ZnO@N-doped C for MeB and FLU dyes are 900 mg g−1 and 100 mg g−1, respectively. According to UV-Vis diffuse reflectance spectroscopy (DRS) data, ZnO@N-doped C has a lower bandgap (2.07 eV) than ZIF-8 (4.34 eV) and ZnO (3.12 eV). Thus, ZnO@N-doped C serves as an effective photocatalyst for the degradation of both dyes under UV exposure. The degradation efficiency capacity of the dye (50 mg L−1) is >90% using 200 mg L−1 of the photocatalyst. The mechanism of adsorption and photocatalysis is investigated. The photodegradation pathway of the dye involved the generation of oxidative hydroxy radicals (OH˙), which can degrade the dyes. The degradation products of FLU were recorded using mass spectrometry.
Designing for Audience Engagement
 Exploring the Use of Online Metrics in the GLAM Sector

Many heritage and cultural professionals have emphasised the ability of online content to reach beyond museums’ traditional audiences, yet one of the largest surveys to date shows no significant change in the demographic breakdown of online and on-site visitors. This paper aims to investigate the discrepancy between the data and the narrative, using two case studies to illustrate the pitfalls of using common social media metrics such as ‘views’, ‘likes’, and ‘shares’. Drawing from the authors’ previous sector-wide study, the paper highlights what shapes these numbers, and questions how useful they are as a measure of ‘audience engagement’. Finally, it looks to computational methods to explore nuanced alternatives that could supersede these metrics in the coming decade.
Blood HBV DNA in newborns from HBsAg-positive mothers might be predictive of immunization response

Background: In Ivory Coast, as in the rest of sub Saharan Africa, despite the introduction of anti-hepatitis B vaccine, toddlers and children remain a segment of the population frequently infected with Hepatitis B Virus (HBV). The conditions of early HBV transmission, and notably the materno-fetal route remain summarily documented in sub Saharan Africa. Methods: From June to November 2018, we analyzed the socio-demographical, serological, and viral features related to HBV transmission in expectant mothers and their newborns who came for delivery at the CHU Cocody Abidjan. Results: Out of 1628 contacted expectant mothers, a subset of 508 accepted to participate to the study, including 163 who were positive for HBsAg. All 56 mothers who transmitted either HBsAg or HBV DNA to their babies were presenting HBV DNA loads >5.0 log10 IU/mL Remarkably, fates of newborns either positive for HBsAg or HBV DNA who completed immune-prophylaxis were drastically different at 9-12 months. While a majority (90%) of HBsAg (+)-only babies became anti-HBs (+), 62.5% DNA-positive newborns failed to mount a proper anti-HBs response. Overall, 10.7% of newborns with at least one positive HBV marker at birth develop a bona fide chronic infection at 9 months. Conclusions: In Ivory Coast, pregnant women presenting HBV DNA loads above 5.0Log10 IU/mL are at risk of maternofetal transmission. Presence of HBV DNA in the blood of newborns represents a better predictor of anti-HBV immunization failure than HBsAg presence. An adaptation of immunization procedures with a passive immune prophylaxis targeting specifically newborns at risk should be urgently considered.
An Effective Algorithm for Quadratic Optimization with Non-Convex Inhomogeneous Quadratic Constraints

This paper considers the NP (Non-deterministic Polynomial)-hard problem of finding a minimum value of a quadratic program (QP), subject to m non-convex inhomogeneous quadratic constraints. One effective algorithm is proposed to get a feasible solution based on the optimal solution of its semidefinite programming (SDP) relaxation problem.
Control of bilateral teleoperators with time delays using only position measurements

A major drawback in the control of bilateral teleoperators is time delays. The nature of the communication channel that interconnects the local and the remote manipulators imposes these delays, which can be time‐varying. Several commercially available robots do not incorporate velocity sensors, and velocities are usually estimated using dirty derivatives. In this paper, we are interested in the control of bilateral teleoperators with variable time delays and without requiring velocity measurements. The proposal makes use of a second‐order dynamical controller that backpropagates damping to the local and the remote manipulators. If sufficient damping is injected in the controller and under the common passivity assumption of the human operator and the environment, it is proved that position errors and velocities are bounded. Invoking Barbalat's lemma, when the human and the environment do not inject forces in the system, it is shown that position error and velocities globally asymptotically converge to zero. A simulation comparison with other two control techniques shows the performance of the novel proposal. Experimental results evidence the robustness of the proposed scheme to interconnecting time delays.
On Zariski topologies on polyrings

We consider universal algebras (K, +, Ω) consisting of an Abelian group (K, +) and a family Ω of additional operations distributive with respect to the group addition, that is, such that the unary operations obtained from them by fixing all but one argument are endomorphisms of the group. We call such algebras polyrings. Particular instances of polyrings are Abelian groups, rings, modules, algebras over a ring, differential rings, and so on. We note that in the class of all polyrings expanding a given group, there is a most expanded polyring. The signature of a polyring K has, besides functional symbols for the group addition and the operations in Ω, a functional symbol for the operation of taking the inverse element in the group and constant symbols for all the elements of K. The set of terms over K in the variables x1, . , xn is denoted by K[x1, . , xn]. We identify the set K with the Cartesian product of n copies of the set K as well as with the section K × {0} of the set K given by the point 0, thereby considering that K ⊆ K. Given a number n, we write x⃗, 0⃗, K⃗ instead of (x1, . . . , xn), (0, . . . , 0), K. We denote the pointwise addition on K⃗ by the same symbol +; for example, x⃗ + y⃗ denotes (x1 + y1, . . . , xn + yn). Any term in which the addition symbol does not occur is called a monomial, and any sum of monomials a polynomial. Clearly, every term over a polyring can be represented by a polynomial. Define the degree of a term with respect to given variables by letting it equal to: the number of occurrences of these variables in the term if it is a monomial, the greatest of the degrees of the monomials occurring in the term if it is a polynomial, and the degree of the polynomial representing the term in the general case. The degree with respect to all variables is just called the degree. The following lemma shows that in polyrings each function defined by a term coincides with an endomorphism up to a function defined by a term of lesser degree; this is the only place using the assumption that the group is Abelian.
Recent Insights into Pregnancy and Lactation-Associated Osteoporosis (PLO)

Abstract During pregnancy and lactation, female physiology adapts to fulfill the fetal and neonatal calcium and phosphorus requirements. The physiological changes that take place during these periods do not affect maternal skeleton resistance to fracture in most of the cases. However, there is a small percentage of women that do experience fragility fractures during these times of life. Pregnancy and lactation-associated osteoporosis (PLO) is an infrequent condition defined by the occurrence of non-traumatic fractures – most frequently vertebral – during the third trimester of gestation and/or the first months of postpartum. Its physiopathology has not yet been completely elucidated. Several authors have reported that risk factors for secondary osteoporosis might be present in up to 80% of the cases of PLO patients. According to recent studies, genetic factors might also play a relevant role in PLO. Given its rarity, the available literature on this condition is limited. Most of the published data consist on case reports and case series articles. There are not any randomized controlled trials regarding this disorder. Although there is consensus about discontinuation of lactation and calcium and vitamin D supplementation as the first steps in the treatment of these patients, there is still controversy regarding the long-term and/or pharmacological management of this condition. Recent data on the use of teriparatide in this population looks promising. In this review, we aimed to revise and summarize current knowledge about the physiopathology and management of PLO.