Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of Photothermal and Photodynamic Diode Laser Therapy in Patients with Peri-implant Mucositis: A Systematic Review

Background To determine whether photodynamic laser therapy or photothermal laser therapy demonstrates greater improvements in the clinical signs of peri-implant mucositis as an adjuvant to mechanical debridement. Material and Methods Electronic databases were used to select articles on February 10th, 2022. The clinical outcomes analysed were the plaque index (PI), probing depth (PD) and bleeding of probing index (BoP). The following PICO question was formulated: Among patients with peri-implant mucositis, does photothermal laser therapy (PT) demonstrate greater improvement in clinical inflammatory signs in comparison to antimicrobial photodynamic therapy (aPDT) as an adjuvant to conventional therapy? Results Seven randomized controlled trials (RCTs) were included in the systematic review. The clinical parameters were compared amongst all studies at baseline and 3-month follow-up appointment. aPDT reduced both PI and PD great than PT. PT showed greater reductions in BoP. Conclusions Conclusions are difficult to generalize due to the heterogeneity in the methodology of the included studies. However, this systematic review suggests that aPDT alongside mechanical debridement demonstrated greater improvements in the PI and PD. Other factors besides the laser therapy itself may account for these findings. As for BoP index, PT demonstrated greater improvements due to its photo-biomodulating effects. Clinical Relevance: In patients with peri-implant mucositis, the combination of photothermal diode laser therapy and mechanical debridement entails promising results in treating and preventing the progression of the pathology. Key words:Peri-implant mucositis, Photothermal diode laser therapy, Photodynamic diode laser therapy, Bleeding on probing.
Dietary Debaryomyces hansenii promotes skin and skin mucus defensive capacities in a marine fish model

The present study explores the effects of two supplementation levels of Debaryomyces hansenii (1.1% and 2.2%) as a probiotic in a reference low fish meal-based diet on the skin mucosal tissue in Sparus aurata. This study includes the evaluation of fish performance coupled with a holistic study of the skin mucosa: i) a transcriptomic study of the skin tissue, and ii) the evaluation of its secreted mucus both in terms of skin mucosal-associated biomarkers and its defensive capacity by means of co-culture analysis with two pathogenic bacteria. Results showed that after 70 days of diet administration, fish fed the diet supplemented with D. hansenii at 1.1% presented increased somatic growth and a better feed conversion ratio, compared to fish fed the control diet. In contrast, fish fed the diet including 2.2% of the probiotic presented intermediate values. Regarding gene regulation, the probiotic administration at 1.1% resulted in 712 differentially expressed genes (DEGs), among which 53.4% and 46.6% were up- and down-regulated, respectively. In particular, D. hansenii modulated some skin biological processes related to immunity and metabolism. Specifically, D. hansenii administration induced a strong modulation of some immune biological-related processes (61 DEGs), mainly involved in B- and T-cell regulatory pathways. Furthermore, dietary D. hansenii promoted the skin barrier function by the upregulation of anchoring junction genes (23 DEGs), which reinforces the physical defense against potential skin damage. In contrast, the skin showed modulated genes related to extracellular exosome and membrane organization (50 DEGs). This modulated functioning is of great interest, particularly in relation to the increased skin mucus defensive capacity observed in the bacterial co-culture in vitro trials, which could be related to the increased modulation and exudation of the innate immune components from the skin cells into the mucus. In summary, the modulation of innate immune parameters coupled with increased skin barrier function and cell trafficking potentiates the skin’s physical barrier and mucus defensive capacity, while maintaining the skin mucosa’s homeostatic immune and metabolic status. These findings confirmed the advantages of D. hansenii supplementation in low fish meal-based diets, demonstrating the probiotic benefits on cultured marine species.
Filtres Passe-Bande Compacts à base de Résonateurs Multi-Sections

Dans cet article, un resonateur base sur une ligne multi-sections est propose. Le principal atout de ce nouveau resonateur repose sur la reduction de sa longueur par rapport au UIR (Resonateur a Impedance Uniforme). Pour illustrer cet avantage, ce resonateur a ete mis en oeuvre dans un filtre passe-bande interdigite d’ordre 3 avec une frequence centrale a 125 MHz. Ce filtre a ete concu, simule et realise. Les mesures montrent un bon accord avec la simulation. Les performances et la compacite du filtre resultant sont ensuite comparees a un filtre interdigite UIR. Le filtre base sur ce nouveau Resonateur Multi-Sections a une empreinte 4 fois plus petite que le filtre interdigite UIR.
Low Back Pain and Its Risk Factors Among Nurses Working in East Bale, Bale, and West Arsi Zone Government Hospitals, Oromia Region, South East Ethiopia, 2021 –Multicenter Cross-Sectional Study

Background Hospital nursing staff are particularly susceptible to low back pain (LBP) a widespread health issue worldwide. There was little available data on the prevalence of LBP and risk factors related to it in this population. Objective Assessed the prevalence of LBP and risk factors in nurses working in South-East Ethiopia’s Oromia region in the East Bale, Bale, and West Arsi zone government hospitals. Methods A cross-sectional study was carried out within an institution in the East Bale, Bale, and West Arsi zone government hospitals; 440 nurses were chosen to use a process of systematic random sampling, and data was gathered between June 1 and July 30, 2021. Using pre-designed questionnaires, I interrogated participants. After being verified as complete, the gathered data was entered into Epi-data version 3.1 and exported to SPSS version 25 for analysis. Bi variate and multivariate logistic regressions with 95% confidence intervals and crude and adjusted odd ratios were generated and interpreted as necessary. To deem a result statistically significant, a p-value of 0.05 or lower was required. Results A total of 427 nurses engaged in the interview out of the 440 participants that wanted to take part in the study, yielding a response rate of 97.1%. Low back pain was 42.6% more common over a year [95% CI: (0.384, 0.476)]. According to the multivariate analysis, females [AOR = 1.791; 95% CI: (1.121, 2.861)], age higher than forty [AOR=2.388, 95% CI: (1.315, 4.337)], age grouped 31–40 years [(AOR=2.064, 95% CI: 1.233, 3.455)], divorced [(AOR=10.288, 95% CI: (3.063, 34.553)], married [(AOR=1.676 (1.675, 16.999)]. Conclusion The study suggests that implementing preventive measures and offering ergonomic training can help reduce LBP among nurses in these hospitals.
Automatic 3D Postoperative Evaluation of Complex Orthopaedic Interventions

In clinical practice, image-based postoperative evaluation is still performed without state-of-the-art computer methods, as these are not sufficiently automated. In this study we propose a fully automatic 3D postoperative outcome quantification method for the relevant steps of orthopaedic interventions on the example of Periacetabular Osteotomy of Ganz (PAO). A typical orthopaedic intervention involves cutting bone, anatomy manipulation and repositioning as well as implant placement. Our method includes a segmentation based deep learning approach for detection and quantification of the cuts. Furthermore, anatomy repositioning was quantified through a multi-step registration method, which entailed a coarse alignment of the pre- and postoperative CT images followed by a fine fragment alignment of the repositioned anatomy. Implant (i.e., screw) position was identified by 3D Hough transform for line detection combined with fast voxel traversal based on ray tracing. The feasibility of our approach was investigated on 27 interventions and compared against manually performed 3D outcome evaluations. The results show that our method can accurately assess the quality and accuracy of the surgery. Our evaluation of the fragment repositioning showed a cumulative error for the coarse and fine alignment of 2.1 mm. Our evaluation of screw placement accuracy resulted in a distance error of 1.32 mm for screw head location and an angular deviation of 1.1° for screw axis. As a next step we will explore generalisation capabilities by applying the method to different interventions.
Development of Diamond Device-Level Heat Spreader for the Advancement of GaN HEMT Power and RF Electronics

Wide bandgap power electronics have been commercialized for many applications. Gallium nitride (GaN) high electron mobility transistor (HEMT) has superior performance in high power and high frequency applications. The thermal dissipation issues such as self-heating have been hurdles for power density and frequency increases. The efforts of thermal management for hot spots elimination have been ongoing to improve device reliability. GaN HEMT can be fabricated on different substrates. The power density has been shown to increase significantly by using substrate with high thermal conductivity. The proximity of diamond device-level heat spreader to active device areas not only improves thermal performance but also changes device characteristics. This overview emphasizes on the dependency of material and processing improvements on the advancement of the integration of GaN HEMT and diamond. This work first overviews the recent advancement of diamond growth processing technology, diamond properties improvement, and the reduction of thermal boundary resistance between GaN and diamond based on mechanisms. Then, the recent advancement of enabled and exploratory integration between GaN HEMT and diamond, device passivation, power density, and performance improvements are summarized. It is followed by a discussion of critical factors to be considered for GaN-on-diamond HEMT device design and optimization for high power and high frequency applications.
Vibronic spectra of molecules – an experiment with a quantum computer simulator

In addition to the exciting fundamental questions of quantum computing and implementation possibilities of quantum computers, it is important to look for application areas of quantum computing, to point out practical cases which justify the need for this technology. Besides the well-known qubit-based quantum computers, there are also devices based on other foundations that can surpass the capabilities of classical computers. Among these, devices operating on the basis of boson sampling have a naturally occurring application: the approximate calculation of the vibrational spectrum of molecules. Two separate research groups, Huh et al. [14] and Wang et al. [22] created quantum simulators based on boson sampling, which were successfully used to calculate the transition probabilities between specific states of small molecules. Following the methodology found in these two articles, this paper presents how the calculations of transition probabilities can be performed on a classical computer using a quantum computer simulator which is based on Gaussian boson sampling.
An Improved Brushless Doubly Fed Generator With Interior PM Rotor for Wind Power Applications

This paper presents a novel interior permanent magnet brushless doubly fed generator (IPM-BDFG) for wind power applications, which is based on the magnetic field modulation theory. The basic structure and working principle of the IPM-BDFG are put forward first. As the rotor structure has a great influence on the performance of the IPM-BDFG, the merits of the IPM rotor are discussed by comparing with the surface-mounted rotor. In order to solve the asymmetry phenomena and reduce the harmonics caused by the introduction of field modulation ring, a three-segmented structure for the outer rotor is adopted. Finally, the performances of the proposed IPM-BDFG are validated by using finite-element analysis (FEA). The FEA results show that the IPM-BDFG with segmented outer rotor has excellent performances and owns good potential in the applications of future large-scale wind power generation systems.
in The Century of Space Science

To permit slight tilting adjustment of a bearer ring with respect to the shaft of an associated printing cylinder upon interposition of a layer of resilient, shock-absorbent, wear-resistant material between the shaft and the shaft-receiving opening of the bearer ring, and to allow for inaccuracies of fit due to this elastic insert, the bearer ring is formed with openings therethrough in alignment with similar openings formed in the end face of the associated cylinder, exact positioned alignment between the bearer ring and the printing cylinder being obtained by introducing adjustment pins through these openings, the adjustment pins having relatively eccentrically offset sections in the bores of the bearer ring and the printing cylinder so that, upon rotation of the eccenter pins, exact concentricity of the bearer ring and the printing cylinder can be obtained.
Atlantic meridional overturning circulation and the Southern Hemisphere supergyre

The ocean's role in climate manifests itself through its high heat capacity, its own rich internal dynamics and its ability to transport vast quantities of heat and freshwater. Of particular interest is the global ocean circulation associated with the Atlantic meridional overturning (AMOC). Because observations are sparse, the detailed global structure of the AMOC remains poorly understood, particularly the pathways along which water returns to the Atlantic to compensate the export of North Atlantic Deep Water (NADW). Here we provide the first quantitative 3‐dimensional global view of the AMOC using a Lagrangian reconstruction which integrates hundred of thousands water particle trajectories in an ocean model. The resulting pattern elucidates the role of the wind in structuring the pathways of the AMOC. In particular, the Lagrangian analysis reveals a strong link with the three subtropical gyres of the southern hemisphere (SH), which merge into a “supergyre” spanning the three ocean basins. The coupling between the upper ocean wind‐driven circulation and the overturning in the model suggests that changes in the SH winds can alter the pathways of the AMOC, and therefore the water properties and the associated heat and freshwater transports.
A Protocol for Organoids from the Urine of Bladder Cancer Patients

This study investigates the feasibility of establishing urine-derived tumor organoids from bladder cancer (BC) patients as an alternative to tissue-derived organoids. BC is one of the most common cancers worldwide and current diagnostic methods involve invasive procedures. Here, we investigated the potential of using urine samples, which contain exfoliated tumor cells, to generate urine-derived BC organoids (uBCOs). Urine samples from 29 BC patients were collected and cells were isolated and cultured in a three-dimensional matrix. The establishment and primary expansion of uBCOs were successful in 83% of the specimens investigated. The culturing efficiency of uBCOs was comparable to cancer tissue-derived organoids. Immunohistochemistry and immunofluorescence to characterize the uBCOs exhibited similar expressions of BC markers compared to the parental tumor. These findings suggest that urine-derived BC organoids hold promise as a non-invasive tool for studying BC and evaluating therapeutic responses. This approach could potentially minimize the need for invasive procedures and provide a platform for personalized drug screening. Further research in this area may lead to improved diagnostic and treatment strategies for BC patients.
The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene

Lycopene is a compound of colored origin that shows strong antioxidant activity. The positive effect of lycopene is the result of its pleiotropic effect. The ability to neutralize free radicals via lycopene is one of the foundations of its pro-health effect, including the ability to inhibit the development of many civilization diseases. Therefore, this study focuses on the importance of the antioxidant effect of lycopene in inhibiting the development of diseases such as cardiovascular diseases, diseases within the nervous system, diabetes, liver diseases, and ulcerative colitis. According to the research mentioned, lycopene supplementation has significant promise for the treatment of illnesses marked by chronic inflammation and oxidative stress. However, the majority of the supporting data for lycopene′s health benefits comes from experimental research, whereas the evidence from clinical studies is both scarcer and less certain of any health benefits. Research on humans is still required to establish its effectiveness.
Exploring Diverse Bioactive Secondary Metabolites from Marine Microorganisms Using Co-Culture Strategy

The isolation and identification of an increasing number of secondary metabolites featuring unique skeletons and possessing diverse bioactivities sourced from marine microorganisms have garnered the interest of numerous natural product chemists. There has been a growing emphasis on how to cultivate microorganisms to enhance the chemical diversity of metabolites and avoid the rediscovery of known ones. Given the significance of secondary metabolites as a means of communication among microorganisms, microbial co-culture has been introduced. By mimicking the growth patterns of microbial communities in their natural habitats, the co-culture strategy is anticipated to stimulate biosynthetic gene clusters that remain dormant under traditional laboratory culture conditions, thereby inducing the production of novel secondary metabolites. Different from previous reviews mainly focusing on fermentation conditions or metabolite diversities from marine-derived co-paired strains, this review covers the marine-derived co-culture microorganisms from 2012 to 2022, and turns to a particular discussion highlighting the selection of co-paired strains for marine-derived microorganisms, especially the fermentation methods for their co-cultural apparatus, and the screening approaches for the convenient and rapid detection of novel metabolites, as these are important in the co-culture. Finally, the structural and bioactivity diversities of molecules are also discussed. The challenges and prospects of co-culture are discussed on behave of the views of the authors.
The impact of the corporate governance on firm performance: Evidence from the Greek listed firms

This article explores the relationship between board quality and firm performance. The authors investigate any association between corporate governance and firm performance using a sample of listed firms on the Athens Stock Exchange (ATHEX) from 2008 to 2016 and two distinct performance models. This article expands on a previous study by Kalantonis et al. (2021) by including financial performance as assessed by both return on assets (ROA) and Tobin’s Q. This investigation provides a global and comprehensive view of how specific aspects of corporate governance (CG) have influenced Greek listed companies during the period 2008–2016. Extending analysis also allows to capture the dynamics of the Greek financial crisis as well as the recent legal institutional framework concerning CG. The authors found that firms with more independent board members performed poorly in terms of ROA, while board size (BS) is positively related to performance in terms of Tobin’s Q. Furthermore, a positive relationship was found between CEO duality (CEOD) and firm performance both in terms of ROA and Tobin’s Q, and no relationship was found between board gender diversification and firm performance. Finally, it was concluded that the investigated GC aspects affect more the firms’ performance than the firms’ earnings management.
Temporal complexity in photoplethysmography and its influence on blood pressure

Objective: The temporal complexity of photoplethysmography (PPG) provides valuable information about blood pressure (BP). In this study, we aim to interpret the stochastic PPG patterns with a model-based simulation, which may help optimize the BP estimation algorithms. Methods: The classic four-element Windkessel model is adapted in this study to incorporate BP-dependent compliance profiles. Simulations are performed to generate PPG responses to pulse and continuous stimuli at various timescales, aiming to mimic sudden or gradual hemodynamic changes observed in real-life scenarios. To quantify the temporal complexity of PPG, we utilize the Higuchi fractal dimension (HFD) and autocorrelation function (ACF). These measures provide insights into the intricate temporal patterns exhibited by PPG. To validate the simulation results, continuous recordings of BP, PPG, and stroke volume from 40 healthy subjects were used. Results: Pulse simulations showed that central vascular compliance variation during a cardiac cycle, peripheral resistance, and cardiac output (CO) collectively contributed to the time delay, amplitude overshoot, and phase shift of PPG responses. Continuous simulations showed that the PPG complexity could be generated by random stimuli, which were subsequently influenced by the autocorrelation patterns of the stimuli. Importantly, the relationship between complexity and hemodynamics as predicted by our model aligned well with the experimental analysis. HFD and ACF had significant contributions to BP, displaying stability even in the presence of high CO fluctuations. In contrast, morphological features exhibited reduced contribution in unstable hemodynamic conditions. Conclusion: Temporal complexity patterns are essential to single-site PPG-based BP estimation. Understanding the physiological implications of these patterns can aid in the development of algorithms with clear interpretability and optimal structures.
Distributed Poisson Surface Reconstruction

Screened Poisson surface reconstruction robustly creates meshes from oriented point sets. For large datasets, the technique requires hours of computation and significant memory. We present a method to parallelize and distribute this computation over multiple commodity client nodes. The method partitions space on one axis into adaptively sized slabs containing balanced subsets of points. Because the Poisson formulation involves a global system, the challenge is to maintain seamless consistency at the slab boundaries and obtain a reconstruction that is indistinguishable from the serial result. To this end, we express the reconstructed indicator function as a sum of a low‐resolution term computed on a server and high‐resolution terms computed on distributed clients. Using a client–server architecture, we map the computation onto a sequence of serial server tasks and parallel client tasks, separated by synchronization barriers. This architecture also enables low‐memory evaluation on a single computer, albeit without speedup. We demonstrate a 700 million vertex reconstruction of the billion point David statue scan in less than 20 min on a 65‐node cluster with a maximum memory usage of 45 GB/node, or in 14 h on a single node.