Miracle-dz/UniFAR-FTUs huggingface dataset:
Tectonic Relations Between İzmir-Ankara Zone and Karaburun Belt

Bati Anadolu'da Izmir cevresinde uc tektonik kusak yer almaktadir. Bu kusaklar dogudan batiya dogru, Menderes masifi, Izmir-Ankara zonu ve Karaburun kusagidir. Menderes masifi, en ust duzeyleri Alt Eosene kadar cikan metamorfik kayalardan olusmustur. Menderes masifi uzerine bindirmis olan Izmir-Ankara zonu, Manisa'dan Seferihisar'a kadar uzanan genis bir bolgede Kampaniyen-Daniyen yasinda olan filis fasiyesinde tortul kayalar ve mafik volkanik arakatkilardan yapili bir matriks ve matriks icinde yuzen boylan 20 km yi asan kirectasi bloklarindan olusmus bir birim Ue temsil edilir. Bornova karmasigi adi verilen bu birimin, matriksinin cokelimi sirasinda kirectasi blok ve megabloklari tortullasma ortamina tasinmis ve bunun sonucu bloklarin cevresinde yumusak Sediment deformasyonlari gozlenen karmasik dokanak yapilan gelismistir. Bu kirectasi megabloklarinin eksikli olculebilen kesitlerinin birlestirilmesiyle elde edilen genellestirilmis stratigrafisi, Karaburun yarimadasinda yuzeylenen karbonat istifine benzerdir. Aynca litolojik ve paleontolojik karsilastirmalar da bu bloklarin Karaburun istifine ait parcalar oldugunu gostermektedir. Karaburun yarimadasinda Ust Kretase, Balikliova koyu cevresinde acisal uyumsuzlukla Triyas-Alt Kretase devamli serisi uzerine tabanda ince bir karbonat ve ustte filis fasiyesinde kirintili tortullarla oturur. Bunun disinda, Karaburun ilce merkezi ve yarimadanin Anadolu'ya baglandigi Urla ilcesi yakininda olmak uzere iki yerde, Bornova karmasigi benzeri kayalarla Karaburun karbonat istifinin iliskisi gozlenmektedir. Bu iki yorede karmasik ic yapili bu kayalarla karbonat istifinin dokanagi, Bornova karmasigi icerisindeki megabloklarin cevresindekine benzer sekildedir ve normal stratigrafik iliskilerle aciklanamayacak yapisal karsiliklar sunar. Tum veriler Karaburun karbonat istifinin Izmir-Ankara zonunun platformu oldugunu ve bu platformun filis cokelimi sirasinda naplasmaya ugradigini gostermektedir. Ilerleyen naptan kopan kutleler Bornova karmasigi icindeki megabloklari olusturmustur. Buna karsilik Karaburun karbonat kusagi ise daha buyuk olcekte allokton kutle seklinde nap paketinin kendisi veya filis ortamina ilerlemis burnunu teskil etmektedir.
Propranolol Does Not Affect Incidence of Spontaneous Bacterial Peritonitis in Cirrhotic Patients With Ascites

Gastrointest Endosc 1999;50:688–91. 4. Da Cruz GMG. Generalized gastrointestinal polyposis. Am J Gastroenterol 1967;47:504–10. 5. Murai N, Fukuzake T, Nakamura T, et al. Cronkhite-Canada syndrome associated with colon cancer. Report of a case. Jpn J Surg 1993;23:825–9. 6. Russell DM, Bhathal PS, St John DJ. Complete remission in Cronkhite-Canada syndrome. Gastroenterol 1983;85:180–5. 7. Murata I, Yoshikawa I, Endo M, et al. Cronchite-Canada syndrome. Report of two cases. J Gastroenterol 2000;35:706– 11. 8. Viranuvatti V, Damrongsak C, Chainuvatti T, et al. CronkhiteCanada syndrome. Report of a case with spontaneous recovery. J Med Assoc Thailand 1981;64:261–6. 9. Malhotra R, Sheffield A. Cronkhite-Canada syndrome associated with colon carcinoma and adenomatous changes in C-C polyps. Am J Gastroenterol 1988;83:772. 10. Nakamura Y, Takagi S, Omoto R, Makino T, Yoshii T. A case of Cronkhite-Canada syndrome associated with cancer development of a gastric polyp [in Japanese with English abstract]. Stomach Intest 1979;14:1217–22.
Three essays on earnings management, financial irregularities, and capital structure

This thesis comprises of three essays. The first essay is titled ‘Do Acquiring Firms Manage Earnings? ’ and is co-authored with Professor Anand M. Vijh. The second essay is titled ‘Do Firms Have a Target Leverage? Evidence from Credit Markets’ and is joint work with Professors Anand M. Vijh and Redouane Elkamhi. The third is essay is single authored and titled ‘Bondholder Wealth Effects of Fraudulent Reporting. ’ In the first essay, we investigate possible earnings management by inflating discretionary accruals in a sample of 1,719 cash acquirers and 895 stock acquirers during 1989-2005. Following previous literature, we document higher ROA-matched discretionary accruals for stock acquirers than for cash acquirers. However, simulation evidence with quarterly data shows that ROA-matched discretionary accruals are misspecified for both high-growth and low-growth firms. This is relevant to the current investigation because the median sales growth rate equals 12.1% for cash acquirers and 38.5% for stock acquirers (besides similar differences in other growth measures). We propose a new discretionary accrual measure that controls for both ROA and sales growth. This measure is well-specified and powerful in detecting earnings management in stratified random samples, and it leads to an insignificant difference between discretionary accruals of cash and stock acquirers. Other tests of acquirer incentives to manage earnings, market reaction to earnings management, and time delay between earnings announcement and merger announcement strengthen the evidence against earnings management attributed to stock acquisitions. In the second essay, we propose credit market based test of whether firms have a target leverage. The static tradeoff theory of capital structure hypothesizes that firms have a target leverage which optimizes firm value in the presence of benefits and costs of leverage (such as taxes and bankruptcy costs). If firms adjust their actual leverage toward this target leverage over time, then rational investors should consider both current and target leverage in pricing contracts whose value depends on the firm’s default risk. Using
Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations*

Background: The mechanism by which SHP2 mutations cause LEOPARD syndrome is poorly understood. Results: LEOPARD syndrome mutations impair SHP2 activity but increase its propensity for an open and active conformation. Conclusion: LEOPARD syndrome SHP2 mutants bind preferentially to upstream activators to prolong substrate turnover, thus engendering gain-of-function phenotypes. Significance: The study provides a framework for understanding how individual SHP2 mutations cause diseases. SHP2 is an allosteric phosphatase essential for growth factor-mediated Ras activation. Germ-line mutations in SHP2 cause clinically similar LEOPARD and Noonan syndromes, two of several autosomal-dominant conditions characterized by gain-of-function mutations in the Ras pathway. Interestingly, Noonan syndrome SHP2 mutants are constitutively active, whereas LEOPARD syndrome SHP2 mutants exhibit reduced phosphatase activity. How do catalytically impaired LEOPARD syndrome mutants engender gain-of-function phenotypes? Our study reveals that LEOPARD syndrome mutations weaken the intramolecular interaction between the N-SH2 and phosphatase domains, leading to a change in SHP2 molecular switching mechanism. Consequently, LEOPARD syndrome SHP2 mutants bind upstream activators preferentially and are hypersensitive to growth factor stimulation. They also stay longer with scaffolding adapters, thus prolonging substrate turnover, which compensates for the reduced phosphatase activity. The study provides a solid framework for understanding how individual SHP2 mutations cause diseases.
ORTHOTOPIC LIVER TRANSPLANTATION IN HIGH-RISK PATIENTS

B virus core antibody on incidence of posttransfusion hepatitis. Lancet 1991; 338: 1040. 18. Chazouilleres O. Mamish D, Kim M. et al. "Occult" hepatitis B virus as source of infection in liver transplant recipients. Lancet 1994; 343: 142. 19. European FK506 Multicentre Liver Study Group. Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. Lancet 1994; 344: 423. 20. McDiarmid SV. Busuttil RW. Ascher NL. et al. FK506 (tacrolimus) compared with cyclosporine for primary immunosuppression after pediatric liver transplantation. Transplantation 1995; 59: 530. 21. Neuhaus P, Blumhardt G, Bechstein WOo et al. Comparison of FK506and cyclosporine-based immunosuppression in primary orthotopic liver transplantation. Transplantation 1995; 59: 31. 22. Hepatitis and hepatocellular carcinoma in South Asia. WHO Assignment Report ICO RPD002SEA 1982. 23. Ihara H, Kato T, Ikeda H, Sekiguchi S. Evaluation of HI method as an anti-HBc screening test. Jpn J Transfusion Med 1990;
Immunoelectron microscopy of rhodopsin and vitamin A in the pineal organ and lateral eye of the lamprey.

Rhodopsin- and vitamin A-immunoreactive sites were studied in the pineal organ of the larval and adult brook lamprey (Lampetra planeri Bloch), as well as in the retina of the larval lateral eye, at the electron microscopic level. In the pineal organ, several types of photoreceptor cells could be distinguished by their morphology and the immunoreactivity of their outer segments. The different kinds of photoreceptor cells were located at different levels of the pineal organ according to their distance from the "pineal window". The most superficial level, the so-called pellucida, appears to represent an exclusively "cone-type" area containing slender, rhodopsin-immunonegative (UV-blue-sensitive? ) photoreceptors only. The second level, the pineal retina, contained predominantly rod-type photoreceptors, i.e., large, strongly rhodopsin-immunopositive (green-sensitive) photoreceptors medially, and few, small, weakly rhodopsin-immunopositive (blue-green-sensitive? ) cells bilaterally. At the deepest level, the pineal atrium, there were both rod- and cone-type photoreceptor cells, the latter possibly representing red-sensitive elements. Vitamin A immunoreactivity was found in the outer segments of the pineal photoreceptor cells, in the cytoplasm and mitochondria of inner segments and perikarya, as well as in nuclear euchromatin and compact nucleoli. A similar gold labelling of organelles was observed in the ependyma and pineal neurons. The vitamin A immunoreaction of the outer segments suggests retinoids are present as chromophores of the photopigments. In the peripheral retina of the larval lateral eye, vitamin A immunoreactivity was found in some organelles of the undifferentiated photoreceptor cells, neurons, pigment epithelium and Müllerian cells. The localization of immunoreactive vitamin A in nuclei, nucleoli and cytoplasm including mitochondria appears to strengthen the case for an interaction of retinoids in the function of these organelles.
Person-centred care: more than just improving patient satisfaction?

This editorial refers to ‘Effects of person-centred care in patients with chronic heart failure: the PCC-HF study’†, by I. Ekman et al. , on page 1112 ARTICLE Health policy has increasingly signalled a move away from an emphasis on specific organs and disease, towards placing the ‘whole’ person at the centre of medicine.1 The health professional must try to understand what the illness means for the individual, within a social and psychological context. This necessitates listening to that particular person's point of view, with the ultimate goal of sharing responsibility with them.2 Clinicians should learn to ask not only ‘what is the matter? ’, but ‘what matters? ’ In other words, what are the patient's interests, concerns, and fears about the specific conditions, symptoms, or treatment options? 3 This moves us from the strictly biomedical view to a broader bio-psycho-social and spiritual view, with power shared between the healthcare professional and the patient.4 Despite widespread pressure for a move from the paternalistic ‘doctor knows best’ approach, progress has been rather slow. All agree that improved communication between patients and professionals is a legitimate goal, but a survey across several developed countries has reported that the majority of patients are not asked for their ideas or opinions about treatment.5 This is particularly troubling as disease management shifts towards chronic rather than acute disease. Many factors influence how person-centred the interactions between a healthcare professional and a patient may be, including the characteristics of the patient and the professional, the context of the interaction, and …
Ancient genomes from North Africa evidence prehistoric migrations to the Maghreb from both the Levant and Europe

Significance The acquisition of agricultural techniques during the so-called Neolithic revolution has been one of the major steps forward in human history. Using next-generation sequencing and ancient-DNA techniques, we directly test whether Neolithization in North Africa occurred through the transmission of ideas or by demic diffusion. We show that Early Neolithic Moroccans are composed of an endemic Maghrebi element still retained in present-day North African populations, resembling the genetic component observed in Later Stone Age communities from Morocco. However, Late Neolithic individuals from North Africa are admixed, with a North African and a European component. Our results support the idea that the Neolithization of North Africa involved both the development of Epipaleolithic communities and the migration of people from Europe. The extent to which prehistoric migrations of farmers influenced the genetic pool of western North Africans remains unclear. Archaeological evidence suggests that the Neolithization process may have happened through the adoption of innovations by local Epipaleolithic communities or by demic diffusion from the Eastern Mediterranean shores or Iberia. Here, we present an analysis of individuals’ genome sequences from Early and Late Neolithic sites in Morocco and from Early Neolithic individuals from southern Iberia. We show that Early Neolithic Moroccans (∼5,000 BCE) are similar to Later Stone Age individuals from the same region and possess an endemic element retained in present-day Maghrebi populations, confirming a long-term genetic continuity in the region. This scenario is consistent with Early Neolithic traditions in North Africa deriving from Epipaleolithic communities that adopted certain agricultural techniques from neighboring populations. Among Eurasian ancient populations, Early Neolithic Moroccans are distantly related to Levantine Natufian hunter-gatherers (∼9,000 BCE) and Pre-Pottery Neolithic farmers (∼6,500 BCE). Late Neolithic (∼3,000 BCE) Moroccans, in contrast, share an Iberian component, supporting theories of trans-Gibraltar gene flow and indicating that Neolithization of North Africa involved both the movement of ideas and people. Lastly, the southern Iberian Early Neolithic samples share the same genetic composition as the Cardial Mediterranean Neolithic culture that reached Iberia ∼5,500 BCE. The cultural and genetic similarities between Iberian and North African Neolithic traditions further reinforce the model of an Iberian migration into the Maghreb.
An accurate retrieval through R-MAC+ descriptors for landmark recognition

The landmark recognition problem is far from being solved, but with the use of features extracted from intermediate layers of Convolutional Neural Networks (CNNs), excellent results have been obtained. In this work, we propose some improvements on the creation of R-MAC descriptors in order to make the newly-proposed R-MAC+ descriptors more representative than the previous ones. However, the main contribution of this paper is a novel retrieval technique, that exploits the fine representativeness of the MAC descriptors of the database images. Using this descriptors called "db regions" during the retrieval stage, the performance is greatly improved. The proposed method is tested on different public datasets: Oxford5k, Paris6k and Holidays. It outperforms the state-of-the-art results on Holidays and reached excellent results on Oxford5k and Paris6k, overcame only by approaches based on fine-tuning strategies.
Mobilisation or dilution? Nitrate response of karst springs to high rainfall events

Nitrate (NO 3 − ) contamination of groundwater associated with agronomic activity is of major concern in many countries. Where agriculture, thin free draining soils and karst aquifers coincide, groundwater is highly vulnerable to nitrate contamination. As residence times and denitrification potential in such systems are typically low, nitrate can discharge to surface waters unabated. However, such systems also react quickest to agricultural management changes that aim to improve water quality. In response to storm events, nitrate concentrations can alter significantly, i.e. rapidly decreasing or increasing concentrations. The current study examines the response of a specific karst spring situated on a grassland farm in South Ireland to rainfall events utilising high-resolution nitrate and discharge data together with on-farm borehole groundwater fluctuation data. Specifically, the objectives of the study are to formulate a scientific hypothesis of possible scenarios relating to nitrate responses during storm events, and to verify this hypothesis using additional case studies from the literature. This elucidates the controlling key factors that lead to mobilisation and/or dilution of nitrate concentrations during storm events. These were land use, hydrological condition and karstification, which in combination can lead to differential responses of mobilised and/or diluted nitrate concentrations. Furthermore, the results indicate that nitrate response in karst is strongly dependent on nutrient source, whether mobilisation and/or dilution occur and on the pathway taken. This will have consequences for the delivery of nitrate to a surface water receptor. The current study improves our understanding of nitrate responses in karst systems and therefore can guide environmental modellers, policy makers and drinking water managers with respect to the regulations of the European Union (EU) Water Framework Directive (WFD). In future, more research should focus on the high-resolution monitoring of karst aquifers to capture the high variability of hydrochemical processes, which occur at time intervals of hours to days.
COMPARISON OF LACTATE DEHYDROGENASE [N SIMULATED HIBERNATING AND ACTIVE ROOM TEMPERATURE TURTLES

approve\=! : " 11J. ,A A.Ad A I \ X )1 l(/ll'd UP Y;r C7 4C;:;:::; :; AN ABSTRACT OF THE THESIS OF Hua Liu for the Master of Science Degree in Biology presented on March 6, 1977 Title: Comparison of lactate dehydrogenase in simulated hibernating and active room The Red-eared slider (Trachemys scripta) is remarkably tolerant to the anoxic conditions of hibernation. During the winter. these turtles hibernate under a thin layer of mud where the temperature is approximately 5 °C and the oxygen availability is close to zero. During hibernation, the turtles are dependent upon anaerobic glycolysis as the primary source of energy generation. As lactate dehydrogenase (LDH) is a key enzyme of the anaerobic pathway, the possible molecular adaptations of LDH in hibernating turtles were investigated in this study. Ten turtles were placed into simulated hibernation at 5 °C for five 1110nths. Control animals were placed in similar conditions at room temperature. Since LDH can exists in the forms of five isozymes, we analyzed LDH isolated from the turtle heart skeletal muscle, and liver by electrophoresis, followed by densitometric analysis. The densitometry was performed to determine if differences in the percentage of the LDH isozymes in these tissues occurred between hibernating and room temperature turtles. The activity ofLDH was also determined at 5 °C and 30°C for each of the above tissues in both groups of turtles. No statistical differences were found in the mean percentage of LDH isozymes when comparing similar tissues between hibernating and room temperature turtles. However. hibernating turtles had higher LDH activities in all tissues tested as compared to the room temperature turtles. At 5 °C the mean LDH activity of the hibernating turtle skeletal muscle was 3.5 times greater, heart and liver were 1.75 times greater than that oflike tissues in room temperature turtles, while at 30°C the mean LDH activity in skeletal muscle was 2.0 and liver 1.5 times greater in hibernating turtles, respectively. Thus, it appears that the LDH activity of hibernating turtles, particularly within skeletal muscle, does adapt during hibernation, a feature which contributes to their survival during these prolonged and extreme periods. COMPARISON OF LACTATE DEHYDROGENASE [N SIMULATED HIBERNATING AND ACTIVE ROOM TEMPERATURE TURTLES
IM Balanced: Influence Maximization Under Balance Constraints

Influence Maximization (IM) is the problem of finding a set of influential users in a social network, so that their aggregated influence is maximized. IM has natural applications in viral marketing and has been the focus of extensive recent research. One critical problem, however, is that while existing IM algorithms serve the goal of reaching a large audience, they may obliviously focus on certain well-connected populations, at the expense of key demographics, creating an undesirable imbalance, an illustration of a broad phenomenon referred to as algorithmic discrimination. Indeed, we demonstrate an inherent trade-off between two objectives: (1) maximizing the overall influence and (2) maximizing influence over a predefined "protected" demographic, with the optimal balance between the two being open to different interpretations. To this end, we present IM-Balanced, a system enabling end users to declaratively specify the desired trade-off between these objectives w.r. t. an emphasized population. IM-Balanced provides theoretical guarantees for the proximity to the optimal solution in terms of both objectives and ensures an efficient, scalable computation via careful adaptation of existing state-of-the-art IM algorithms. Our demonstration illustrates the effectiveness of our approach through real-life viral marketing scenarios in an academic social network.