Miracle-dz/UniFAR-FTUs huggingface dataset:
Evolutionary Analysis of Placental Orthologues Reveals Two Ancient DNA Virus Integrations

The genomes of vertebrates preserve a large diversity of endogenous viral elements (remnants of ancient viruses that accumulate in host genomes over evolutionary time). Although retroviruses account for the vast majority of these elements, diverse DNA viruses have also been found and novel lineages are being described. ABSTRACT The genomes of eukaryotes preserve a vast diversity of ancient viruses in the form of endogenous viral elements (EVEs). Study of this genomic fossil record provides insights into the diversity, origin, and evolution of viruses across geological timescales. In particular, Mavericks have emerged as one of the oldest groups of endogenous viruses infecting vertebrates (≥419 million years [My]). They have been found in the genomes of fish, amphibians, birds, and nonavian reptiles but had been overlooked in mammals. Thus, their evolutionary history and the causes of their demise in mammals remain puzzling questions. Here, we conducted a detailed evolutionary study of two Maverick integrations found on human chromosomes 7 and 8. We performed a comparative analysis of the integrations and determined their orthology across placental mammals (Eutheria) via the syntenic arrangement of neighboring genes. The integrations were absent at the orthologous sites in the genomes of marsupials and monotremes. These observations allowed us to reconstruct a time-calibrated phylogeny and infer the age of their most recent common ancestor at 127 to 262 My. In addition, we estimate the age of the individual integrations at ~102 My, which represents the oldest nonretroviral EVEs found in the human genome. Our findings suggest that active Mavericks still existed in the ancestors of modern mammals ~172 My ago (Jurassic Period) and potentially to the end of the Early Cretaceous. We hypothesize that Mavericks could have gone extinct in mammals from the evolution of an antiviral defense system or from reduced opportunities for transmission in terrestrial hosts. IMPORTANCE The genomes of vertebrates preserve a large diversity of endogenous viral elements (remnants of ancient viruses that accumulate in host genomes over evolutionary time). Although retroviruses account for the vast majority of these elements, diverse DNA viruses have also been found and novel lineages are being described. Here, we analyzed two elements found in the human genome belonging to an ancient group of DNA viruses called Mavericks. We studied their evolutionary history, finding that the elements are shared between humans and many different species of placental mammals. These observations suggest that the elements inserted at least ~102 million years ago (Mya) in the most recent common ancestor of placentals. We further estimated the age of the viral ancestor at around 127 to 262 My. Our results provide evidence for some of the oldest viral integrations in the human genome and insights into the ancient interactions of viruses with the ancestors of modern-day mammals.
A candidate dual AGN in a double-peaked emission-line galaxy with precessing radio jets

We present high resolution radio continuum observations with the Karl G. Jansky Very Large Array at 6, 8.5, 11.5 and 15 GHz of the double-peaked emission-line galaxy 2MASXJ12032061+1319316. The radio emission has a prominent S-shaped morphology with highly symmetric radio jets that extend over a distance of $\sim1.5^{\prime\prime}$ (1.74~kpc) on either side of the core of size $\sim0.1^{\prime\prime}$(116~pc). The radio jets have a helical structure resembling the precessing jets in the galaxy NGC~326 which has confirmed dual active galactic nuclei (AGN). The nuclear bulge velocity dispersion gives an upper limit of $(1.56\pm$0.26$)\times$10$^8$~M$_{\odot}$ for the total mass of nuclear black hole(s). We present a simple model of precessing jets in 2MASXJ1203 and find that the precession timescale is around 10$^5$ years: this matches the source lifetime estimate via spectral aging. We find that the expected super massive black hole (SMBH) separation corresponding to this timescale is 0.02 pc. We used the double peaked emission lines in 2MASXJ1203 to determine an orbital speed for a dual AGN system and the associated jet precession timescale, which turns out to be more than the Hubble time, making it unfeasible. We conclude that the S-shaped radio jets are due to jet precession caused either by a binary/dual SMBH system, a single SMBH with a tilted accretion disk or a dual AGN system where a close pass of the secondary SMBH in the past has given rise to jet precession.
Classicality of quantum information processing

The ultimate goal of the classicality program is to quantify the amount of quantumness of certain processes. Here, classicality is studied for a restricted type of process: quantum information processing (QIP). Under special conditions, one can force some qubits of a quantum computer into a classical state without affecting the outcome of the computation. The minimal set of conditions is described and its structure is studied. Some implications of this formalism are the increase of noise robustness, a proof of the quantumness of mixed state quantum computing, and a step forward in understanding the very foundation of QIP.
Nonminimally coupled scalar field in teleparallel gravity: boson stars

We study the nonminimally coupled complex scalar field within the framework of teleparallel gravity. Coupling of the field nonminimally to the torsion scalar destroys the Lorentz invariance of the theory in the sense that the resulting equations of motion depend on the choice of a tetrad. For the assumed static spherically symmetric spacetime, we find a tetrad which leads to a self-consistent set of equations, and we construct the self-gravitating configurations of the scalar field—boson stars. The resulting configurations develop anisotropic principal pressures and satisfy the dominant energy condition. An interesting property of the configurations obtained with sufficiently large field-to-torsion coupling constant is the outwardly increasing energy density, followed by an abrupt drop towards the usual asymptotic tail. This feature is not present in the boson stars with the field minimally or nonminimally coupled to the curvature scalar, and therefore appears to be a torsion-only effect.
Fresh Produce Delivery to Middle School Youth: Outcomes of a Case Study in Providing Fresh Fruit and Vegetables to Underserved Youth

Purpose The purpose of this study was to evaluate a weekly school-based fruit and vegetable delivery via a mobile market on urban middle schoolers’ nutrition behaviors. Design One-group, pretest-posttest design, quasi-experimental intervention in middle schoolers (6th-8th graders, N = 158) in Kansas City, MO Intervention Weekly delivery of free produce via a mobile market over 12 weeks. Measures A self-administered survey to assess self-report consumption of fruits, vegetables, soda, and sports drinks. Analysis Univariate and bivariate analyses were used. Proportions were compared and chi-square tests were conducted to compare youth at baseline and 12 weeks. Results More youth reported consuming fresh fruit (73.8% to 83.3%; χ2 = 7.76, P = .005) and vegetables (66.4% to 71.3%; χ2 = 13.55, P = <.001) from baseline to follow-up. Less youth reported soda (49.0% to 52.8%; χ2= 6.33, P = .012) and sports drinks (41.8% to 38.2%; χ2= 12.32, P < .001) from baseline to follow-up. Conclusions A mobile produce delivery intervention, like the Healthy Harvest Mobile Market, may be an effective strategy to increase fruit and vegetable consumption for adolescents.
Clinical Outcomes of Percutaneous Endoscopic Lumbar Discectomy Assisted With Sequential SNRB in Treating Lumbosacral Contiguous Double-Level Disc Herniation.

BACKGROUND For patients with lumbosacral contiguous double-level disc herniation, there has been no consensus on which level(s) should be treated. Selective nerve root block (SNRB) can identify the pain-generating nerve root; however, its diagnostic accuracy remains controversial due to potential spread of the injectate. Sequential SNRB from S1 to L5 may improve the diagnostic specificity. OBJECTIVES To examine the clinical and radiographic outcomes of percutaneous endoscopic lumbar discectomy (PELD) assisted with sequential SNRB from S1 to L5 in patients who had lumbosacral contiguous double-level disc herniation. STUDY DESIGN A retrospective design was used. SETTING This study was conducted in a university-affiliated tertiary hospital in Shanghai, China. METHODS Fifty-eight consecutive patients with lumbosacral contiguous double-level disc herniation were included (January 2018 to January 2021). Sequential SNRB from S1 to L5 was performed to identify the symptomatic level(s), followed by PELD based on the results of sequential SNRB. Clinical outcomes were assessed by the Visual Analog Scale (VAS), Oswestry Disability Index (ODI), and modified Macnab criteria. Pre- and post-operation radiologic and clinical parameters were evaluated. Demographics were retrieved from medical records. RESULTS Patients were followed-up with an average duration of 18.6 months. Among the 58 patients, 21 received surgical treatment at L4/L5 level, 25 at L5/S1 level, and 12 at both levels based on the results of sequential SNRB from S1 to L5. Compared with preoperative values, mean VAS scores for leg and back pain, as well as the ODI score, improved significantly after the surgery. There were no significant differences in the clinical outcomes between patients receiving surgical treatment at L4/L5, L5/S1, or both levels. According to the Macnab criteria, 49 patients (84.5%) had excellent or good results. LIMITATIONS This study used a retrospective design with relatively small sample size and medium follow-up duration. CONCLUSIONS Sequential SNRB from S1 to L5 was an effective approach to guide PELD treatment for patients with lumbosacral contiguous double-level disc herniation. Health care providers may consider using this approach to facilitate future clinical practice.
Dynamics of the inflationary flow equations

We present a dynamical analysis of the inflationary flow equations. Our technique uses the Hubble 'jerk' parameter {xi}{identical_to}(m{sub Pl}{sup 4}/16{pi}{sup 2})H{sup -2}(dH/d{phi}d{sup 3}H/d{phi}{sup 3}) (where H is the Hubble parameter and {phi} the inflaton) as a discriminant of stability of fixed points. The results of the analysis are used to explain qualitatively the distribution of various observable parameters (e.g. the tensor-scalar ratio, r, and scalar spectral index, n{sub s}) seen in numerical solutions of the flow equations using stochastic initial conditions. Finally, we give a physical interpretation of the flow in phase-space in terms of slow-roll motion of the inflaton.
Neuromuscular blocking agent induced hypersensitivity reaction exploration: an update

Acute hypersensitivity reactions (AHRs) occurring in present-day anaesthesia can have severe, sometimes fatal, consequences and their incidence is increasing. The most frequent allergens responsible for AHR during anaesthesia are neuromuscular blocking agents (NMBAs) (70% of the cases) followed by antibiotics (18%), patent blue dye and methylene blue dye (5%), and latex (5%). Following an AHR, strategies for subsequent anaesthetic procedures (especially the choice of an NMBA) may be difficult to formulate due to inconclusive diagnostic analysis in up to 30% of AHRs. Current diagnosis of AHR relies on the detection of mast cell degranulation products and drug-specific type E immunoglobulins (IgE) in order to document an IgE-mediated anaphylaxis (IgE endotype). Nonetheless, other IgE-independent pathways can be involved in AHR, but their detection is not currently available in standard situations. The different mechanisms (endotypes) involved in peri-operative AHR may contribute to the inconclusive diagnostic work-up and this generates uncertainty concerning the culpable drug and strategy for subsequent anaesthetic procedures. This review provides details on the IgE endotype; an update on non-IgE related endotypes and the novel diagnostic tools that could characterise them. This detailed update is intended to provide explicit clinical reasoning tools to the anaesthesiologist faced with an incomplete AHR diagnostic work-up and to facilitate the decision-making process regarding anaesthetic procedures following an AHR to NMBAs.
ASW-Net: Adaptive Spectral Wavelet Network for Accurate Fetal ECG Extraction

Noninvasive fetal ECG (FECG) is of great significance for monitoring fetal health. However, it is challenging to extract FECG signals from the abdominal ECG signal (AECG) due to the complexity of the task: 1) FECG signals are routinely mixed with noise; 2) FECG signals are aliased with maternal ECG signals in the time and frequency domain. To solve such problems, an adaptive spectral wavelet network (ASW-Net) is proposed for FECG extraction, where the adaptive spectral wavelet module, which can improve the computational efficiency by replacing convolution operation with element-wise Hadamard product in the frequency domain, is first developed to extract FECG components with different frequencies; then, the residual attention module is devised to distinguish FECG signals from noise by capturing waveform details; finally, the inverse spectral wavelet module is designed to reconstruct FECG signals from multi-resolution FECG components. Experiments conducted on the benchmarks demonstrate that the proposed ASW-Net outperforms the state-of-the-art methods.
Sequential Transmission of Influenza Viruses in Ferrets Does Not Enhance Infectivity and Does Not Predict Transmissibility in Humans

Airborne transmission in ferrets is used to gauge the pandemic potential of emerging influenza viruses; however, some emerging influenza viruses that transmit between ferrets do not spread between humans. Therefore, we evaluated sequential rounds of airborne transmission in ferrets as a strategy to enhance the predictive accuracy of the ferret model. ABSTRACT Airborne transmission in ferrets is a key component of pandemic risk assessment. However, some emerging avian influenza viruses transmit between ferrets but do not spread in humans. Therefore, we evaluated sequential rounds of airborne transmission as an approach to enhance the predictive accuracy of the ferret model. We reasoned that infection of ferrets via the respiratory route and onward transmission would more closely model transmission in humans. We hypothesized that pandemic and seasonal viruses would transmit efficiently over two rounds of transmission, while emerging avian viruses would fail to transmit in a second round. The 2009 pandemic H1N1 (pdm09) and seasonal H3N2 viruses were compared to avian-origin H7N9 and H3N8 viruses. Depending on the virus strain, transmission efficiency varied from 50 to 100% during the first round of transmission; the efficiency for each virus did not change during the second round, and viral replication kinetics in both rounds of transmission were similar. Both the H1N1pdm09 and H7N9 viruses acquired specific mutations during sequential transmission, while the H3N2 and H3N8 viruses did not; however, a global analysis of host-adaptive mutations revealed that minimal changes were associated with transmission of H1N1 and H3N2 viruses, while a greater number of changes occurred in the avian H3N8 and H7N9 viruses. Thus, influenza viruses that transmit in ferrets maintain their transmission efficiency through serial rounds of transmission. This answers the question of whether ferrets can propagate viruses through more than one round of airborne transmission and emphasizes that transmission in ferrets is necessary but not sufficient to infer transmissibility in humans. IMPORTANCE Airborne transmission in ferrets is used to gauge the pandemic potential of emerging influenza viruses; however, some emerging influenza viruses that transmit between ferrets do not spread between humans. Therefore, we evaluated sequential rounds of airborne transmission in ferrets as a strategy to enhance the predictive accuracy of the ferret model. Human influenza viruses transmitted efficiently (>83%) over two rounds of airborne transmission, demonstrating that, like humans, ferrets infected by the respiratory route can propagate the infection onward through the air. However, emerging avian influenza viruses with associated host-adaptive mutations also transmitted through sequential transmission. Thus, airborne transmission in ferrets is necessary but not sufficient to infer transmissibility in humans, and sequential transmission did not enhance pandemic risk assessment.
Should I Stay or Should I Go? Behavioral Acts That Negatively Affect Relationships’ Prospects

Intimate relationships are not easy to keep as the high rates of divorce and singlehood testify. The current research aimed to examine the behavioral acts which are likely to have a negative effect on people's willingness to continue an intimate relationship. More specifically, by using qualitative research methods on a sample of 269 Greek-speaking participants, Study 1 identified 88 acts that have a negative impact on people's willingness to continue an intimate relationship. Study 2 employed quantitative research methods on a sample of 536 Greek speaking participants, and classified these acts into six broader factors. The one with the most negative impact was rated to be the “Does not care about me,” followed by the “Does not treat well our children,” and the “Tries to control me. ” Women and single participants rated the identified factors more negatively than men and participants who were in a relationship or married. Significant main effects of age, sex, relationship status and having children were also found for several factors.
Quantum state discrimination with quantum coherence

Unambiguous quantum state discrimination, assisted by an auxiliary system, generally requires quantum correlations as a resource. A particular case of unambiguous quantum state discrimination requiring only quantum discord without entanglement was introduced by Roa \emph{et al}. [\href{this https URL}{Phys. Rev. Lett. {\bf 107}, 080401 (2011)}]. Also, after the resource-theoretic formulation of quantum coherence, the transformation relations between quantum coherence and quantum correlations have been studied extensively. We propose here a protocol that requires only coherence to unambiguously discriminate nonorthogonal quantum states, and also quantify the required coherence for the optimal unambiguous quantum state discrimination strategy in some particular cases.
Effect of interchain coupling on conducting polymer luminescence: Excimers in derivatives of poly(phenylene vinylene)

Optical excitation of a chain in a polymer film may result in formation of an excimer, a superposition of on-chain excitons and charge-transfer excitons on the originally excited chain and a neighboring chain. The excimer emission is red-shifted compared to that of an on-chain exciton by an amount depending on the interchain coupling $t_\perp$. Setting up the excimer wavefunction and calculating the red shift, we determine average $t_\perp$ values, referred to a monomer, of 0.52 eV and 0.16 eV for poly(2,5-hexyloxy $p$-phenylene cyanovinylene), CN-PPV, and poly[2-methoxy, 5-(2'-ethyl-hexyloxy)-1, 4 p-phenylene vinylene], MEH-PPV, respectively, and use them to determine the effect of interchain distance on the emission.
Linear growth and prevalence of the different components of the metabolic syndrome (MetS) in young obese nondiabetic children (below 5 years) in comparison to older obese children (6-12 years)

Background and aim: In Qatar, the prevalence of metabolic syndrome (MetS) in children and adults is increasing in parallel with the markedly increasing trends in obesity rates. Objective: The aim of our study was to assess the prevalence of different components of MetS, measure plasma atherogenic indexes (AIP), and to evaluate linear growth in young obese nondiabetic children (< 5 years) in comparison to older obese children (6-12 years). Methods: We analysed the anthropometric and biochemical profile of 135 random sample obese children who attended to the Paediatric Clinic of Hamad Medical Centre (HGH) in Doha (Qatar) from January 2018 to December 2019. Results: A large proportion of children presented with obesity, around the age of 5 years, were obese at the end of their first year of life (63.8%) and more were obese at the 2 years of age (82.6%). Significantly rapid gain in weight and linear growth occurred during the first 6 months of postnatal life. Moreover, some metabolic risk factors and high AIP occurred more frequently in older obese children compared to young obese children. Conclusions: This study documented the early occurrence of different components of the MetS in young obese children and the progressive increase of their prevalence in older prepubertal children. Most of obese children who presented at or below 5 years of age had significant obesity and rapid linear growth during the first two years (infancy). These two findings pointed out to the necessity to impose early detection and preventive measures on a national scale. (www.actabiomedica.it)
Steam turbine power prediction based on encode-decoder framework guided by the condenser vacuum degree

The steam turbine is one of the major pieces of equipment in thermal power plants. It is crucial to predict its output accurately. However, because of its complex coupling relationships with other equipment, it is still a challenging task. Previous methods mainly focus on the operation of the steam turbine individually while ignoring the coupling relationship with the condenser, which we believe is crucial for the prediction. Therefore, in this paper, to explore the coupling relationship between steam turbine and condenser, we propose a novel approach for steam turbine power prediction based on the encode-decoder framework guided by the condenser vacuum degree (CVD-EDF). In specific, the historical information within condenser operation conditions data is encoded using a long-short term memory network. Moreover, a connection module consisting of an attention mechanism and a convolutional neural network is incorporated to capture the local and global information in the encoder. The steam turbine power is predicted based on all the information. In this way, the coupling relationship between the condenser and the steam turbine is fully explored. Abundant experiments are conducted on real data from the power plant. The experimental results show that our proposed CVD-EDF achieves great improvements over several competitive methods. our method improves by 32.2% and 37.0% in terms of RMSE and MAE by comparing the LSTM at one-minute intervals.