Miracle-dz/UniFAR-FTUs huggingface dataset:
Hydraulic Characteristics of Forced Harmonic Oscillator Constituting Flap-Type Wave Energy Converter: A Numerical Study Using Dynamic Mesh Method (Arbitrary Mesh Interface)

ABSTRACT Chang, P.-S. ; Cho, Y.J., and Hong, C. -B. , 2023. Hydraulic characteristics of a forced harmonic oscillator constituting the flap-type wave energy converter: A numerical study using dynamic mesh method (Arbitrary Mesh Interface). In: Lee, J.L. ; Lee, H. ; Min, B.I. ; Chang, J.-I. ; Cho, G.T. ; Yoon, J.-S. , and Lee, J. (eds.), Multidisciplinary Approaches to Coastal and Marine Management. Journal of Coastal Research, Special Issue No. 116, pp. 558-562. Charlotte (North Carolina), ISSN 0749-0208. In an effort to develop the WEC (Wave Energy Converter) optimized for Korean marine environment, which is structurally different from those in Europe and the United States, we carried out numerical simulation to look into the power generation efficiency of a forced harmonic oscillator constituting the flap-type WEC. The numerical simulations were conducted using the OlaFlow toolbox, which is based on OpenFoam. In doing so, for numerical simulation of great accuracy, the interaction between the flap-type WEC and incoming waves was described using SixDoFSolidBodyMotion solver and dynamic mesh method such as Morphing Mesh and AMI (Arbitrary Mesh Interface), where computational mesh is adjusted fittingly whenever a forced harmonic oscillator undergoes rotational motion. Numerical results indicate that the oscillator's mass is a key design factor that determines the power generation efficiency of the WEC. If an oscillator is heavier than a critical value, rotational motion of oscillator is centered on the second quadrant, and if an oscillator is lighter than a critical value, its motion is centered on the first quadrant, leading to more efficient harvest of wave energy. The maximum rotational displacement of the oscillator in the shoreward direction occurred after the wave crest passed it, with a time lag due to the oscillator's inertia. In contrast, the maximum displacement in the offshore direction occurred before the arrival of the wave crest. Surprisingly, the maximum force of the wave in the shoreward direction was observed in relatively short waves, rather than in long waves, which was unexpected. These results can be ascribed to the fact that when incoming waves are relatively long, a forced harmonic oscillator is deeply laid down due to larger wave force acting on it. Additionally, when the incoming waves are relatively long, the offshore-directed reflected waves from the forced harmonic oscillator appear to contribute to the effect as well. The numerical results also indicate that the wave force caused by fluid viscosity represents approximately 0.1% of the total wave force. As expected, the longer the incoming waves, the greater the moment acting on the hinge of the WEC becomes.
Yacon Juice Residue Supplementation in Low Fish Meal Diet for Black Rockfish (Sebastes schlegelii)

ABSTRACT Lee, T.H. ; Oh, H.Y. ; Kim, K. -D. , and Kim, H.S. , 2023. Yacon juice residue supplementation in low fish meal diet for black rockfish (Sebastes schlegelii). In: Lee, J.L. ; Lee, H. ; Min, B.I. ; Chang, J.-I. ; Cho, G.T. ; Yoon, J.-S. , and Lee, J. (eds.), Multidisciplinary Approaches to Coastal and Marine Management. Journal of Coastal Research, Special Issue No. 116, pp. 538-542. Charlotte (North Carolina), ISSN 0749-0208. This sudy evaluated the effects of Yacon Juice Residue (YJR) on the growth performance, lysozyme and antioxidant enzyme activities, and disease resistance against Streptococcus iniae of juvenile black rockfish (Sebastes schlegelii) fed a low Fish Meal (FM) diet supplemented with soy and corn protein concentrates. We considered a 60% FM-based diet as a High FM (HF) diet; and a diet in which 30% FM was substituted with a mixture of soy and corn protein concentrates was considered a Low FM (LF) diet. Another six experimental diets, prepared in triplicate, consisted of the LF diet supplemented with YJR at levels of 2.5 g/kg, 5 g/kg, and 10 g/kg (designated as LFY2.5, LFY5, and LFY10 diets, respectively). At the end of the 8-week feeding trial, the highest growth performance (final body weight, weight gain and specific growth rate) was observed in fish fed with the HF diet. Furthermore, fish fed the LFY5 and LFY10 diets had significantly higher growth performances than fish fed the LF diet. All the dietary treatments had similar feed efficiency. Higher lysozyme activity were observed in fish fed the HF and LFY10 diets compared to fish fed the other diets. Plasma superoxide dismutase and catalase activities of the LF diet were significantly enhanced by dietary YJR supplementation. Disease resistance of fish against S. iniae was significantly improved by dietary YJR. The findings demonstrate that supplementing the diet with YJR can partially mitigate growth retardation associated with a diet high in soy and corn protein concentrates, as well as enhance fish antioxidant capacity and disease resistance.
Landscape Preference for Tourism Resourceization of Coastal Bridges in Busan, Republic of Korea

ABSTRACT Lee, S. ; Lee, H. , and Lee, C. , 2023. Landscape preference for tourism resourceization of coastal bridges in Busan, Republic of Korea. In: Lee, J.L. ; Lee, H. ; Min, B.I. ; Chang, J.-I. ; Cho, G.T. ; Yoon, J.-S. , and Lee, J. (eds.), Multidisciplinary Approaches to Coastal and Marine Management. Journal of Coastal Research, Special Issue No. 116, pp. 523-527. Charlotte (North Carolina), ISSN 0749-0208. Busan's Coastal Ring Road features seven bridges that traverse the city, and the 'Seven Bridges Landmark Project' aims to utilize these bridges to create a unique city brand. The project involves analyzing the environment surrounding each bridge, identifying brand images and storytelling that can be used to establish a long-term marketing strategy. Although the Gwangan Bridge and Yeongdo Bridge is already recognized as a landmark of Busan, the other five bridges are still waiting to be discovered. To increase public interest, the Seven Bridges' storytelling and content should emotionally connect with the audience, providing diverse and compelling content that stimulates the desire to visit. The purpose of this study is to propose a utilization plan for bridge landscape images, which can be used to develop tourism and city branding around the Seven Bridges landmark in Busan. The study focuses on comparing the day and night views of the seven bridges, both from the road and from a distance. A survey of 126 men and women was conducted to compare their preferences for different types of landscapes of the Busan Seven Bridges. The results showed that the night view was preferred over the day view for all seven bridges. Additionally, the study proposes a basic method for utilizing bridge landscapes as a resource for tourism development and identifies future research tasks to be pursued in greater depth.
Palliative medicine specialist and general practitioner interactions: national survey

Objectives The purpose of the study was to investigate the collaboration between primary care and palliative care physicians, which is key to providing comprehensive care, and to identify potential difficulties and needs in referring patients to palliative care. Methods The study was conducted as an online survey, available to primary care and palliative care physicians. The data collected during the survey were used to compare perceptions of different specialty physicians’ perspectives on various aspects regarding palliative care. Results The results of the study showed significant differences in the assessment of the palliative care services availability (73% of primary care physicians rate it poorly comparing to high rating of 60% by palliative care specialists), as well as disparities between the declarations regarding the criteria used to decide on referral to palliative care (achieving the best quality of life) and the actual referral of patients (primary care physicians are third on the list of specialists referring patients to palliative care). Despite the need for adequate cooperation between family physicians and palliative care physicians, some difficulties were identified, such as primary care physicians’ lack of knowledge of the patient palliative care referral criteria, and financial as well as personnel and palliative care facilities’ limitations, were identified. Conclusions The study confirms the need for better cooperation between primary care physicians and palliative care specialists in Poland. It suggests that educating primary care physicians about palliative care referral criteria can improve the patient referrals accuracy.
Guillain-Barré syndrome following primary cytomegalovirus infection in a patient with liver transplantation

We present the case of a man in his 60s with a 5-month medical history of deceased donor liver transplantation, who developed Guillain-Barré syndrome (GBS) secondary to a primary cytomegalovirus (CMV) infection. This was confirmed by molecular tests and serology antibodies that ruled out other frequent aetiologies. Therapy with intravenous immunoglobulin and valganciclovir was started and the patient gradually improved over the weeks. GBS is the most common aetiology of paralysis worldwide, and it is an autoimmune-mediated neuropathy that is frequently caused by a preceding infection. Few cases of GBS have been reported in the context of liver transplant recipients, and those related to CMV infection are extremely rare. This case highlights the importance of considering GBS as a possible differential diagnosis in patients with solid organ transplantation, and it contributes to the knowledge of other infrequent aetiologies of this condition.
A nucleoid-associated protein is involved in the emergence of antibiotic resistance by promoting the frequent exchange of the replicative DNA polymerase in M. smegmatis

Antibiotic resistance in M. tuberculosis exclusively originates from chromosomal mutations, either during normal DNA replication or under stress, when the expression of error-prone DNA polymerases increases to repair damaged DNA. To bypass DNA lesions and catalyze error-prone DNA synthesis, translesion polymerases must be able to access the DNA, temporarily replacing the high-fidelity replicative polymerase. The mechanisms that govern polymerase exchange are not well understood, especially in mycobacteria. Here, using a suite of quantitative fluorescence imaging techniques, we discover that, as in other bacterial species, in M. smegmatis, the replicative polymerase, DnaE1, exchanges at a timescale much faster than that of DNA replication. Interestingly, this fast exchange rate depends on an actinobacteria-specific nucleoid-associated protein (NAP), Lsr2. In cells missing lsr2, DnaE1 exchanges less frequently, and the chromosome is replicated more faithfully. Additionally, in conditions that damage DNA, cells lacking lsr2 load the complex needed to bypass DNA lesions less effectively and, consistently, replicate with higher fidelity but exhibit growth defects. Together, our results show that Lsr2 promotes dynamic flexibility of the mycobacterial replisome, which is critical for robust cell growth and lesion repair in conditions that damage DNA. Importance Unlike many other pathogens, M. tuberculosis has limited ability for horizontal gene transfer, a major mechanism for developing antibiotic resistance. Thus, the mechanisms that facilitate chromosomal mutagenesis are of particular importance in mycobacteria. Here, we show that Lsr2, a nucleoid-associated protein, has a novel role in DNA replication and mutagenesis in the model mycobacterium M. smegmatis. We find that Lsr2 promotes the fast exchange rate of the replicative DNA polymerase, DnaE1, at the replication fork and is important for the effective loading of the DnaE2-ImuA’-ImuB translesion complex. Without lsr2, M. smegmatis replicates its chromosome more faithfully and acquires resistance to rifampin at a lower rate, but at the cost of impaired survival to DNA damaging agents. Together, our work establishes Lsr2 as a potential factor in the emergence of mycobacterial antibiotic resistance.
Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat Streptococcus pyogenes skin and soft tissue infection

We have developed GmPcides from a peptidomimetic dihydrothiazolo ring-fused 2-pyridone scaffold that have antimicrobial activities against a broad-spectrum of Gram-positive pathogens. Here we examine the treatment efficacy of GmPcides using skin and soft tissue infection (SSTI) and biofilm formation models by Streptococcus pyogenes. Screening our compound library for minimal inhibitory (MIC) and minimal bactericidal (MBC) concentrations identified GmPcide PS757 as highly active against S. pyogenes. Treatment of S. pyogenes biofilm with PS757 revealed robust efficacy against all phases of biofilm formation by preventing initial biofilm development, ceasing biofilm maturation and eradicating mature biofilm. In a murine model of S. pyogenes SSTI, subcutaneous delivery of PS757 resulted in reduced levels of tissue damage, decreased bacterial burdens and accelerated rates of wound-healing, which were associated with down-regulation of key virulence factors, including M protein and the SpeB cysteine protease. These data demonstrate that GmPcides show considerable promise for treating S. pyogenes infections.
Epigenetic Modulation to perturb the SYNGAP1 Intellectual Disability (ID) that ameliorates synaptic and behavioural deficits

Sporadic heterozygous mutations in SYNGAP1 affects social and emotional behaviour that are often observed in intellectual disability (ID) and autism spectrum disorder (ASD). Although neurophysiological deficits have been extensively studied, the epigenetic landscape of SYNGAP1 mutation-mediated intellectual disability is unexplored. Here, we have surprisingly found that the p300/CBP specific acetylation marks of histones are significantly repressed in the adolescent hippocampus of Syngap1+/- mouse. To establish the causal relationship of Syngap1+/- phenotype and the altered histone acetylation signature we have treated 2-4 months old Syngap1+/- mouse with glucose-derived carbon nanosphere (CSP) conjugated potent small molecule activator (TTK21) of p300/CBP lysine acetyltransferase (CSP-TTK21). The enhancement of the p300/CBP specific acetylation marks of histones by CSP-TTK21 restored deficits in spine density, synaptic function, and social preferences of Syngap1+/- mouse that is very closely comparable to wild type littermates. The hippocampal RNA-Seq analysis of the treated mice revealed that the expression of many critical genes related to the ID/ASD reversed due to the treatment of the specific small molecule activator. This study could be the first demonstration of the reversal of autistic behaviour and neural wiring upon the modulation of altered epigenetic modification (s).
Intensity mismatch asymmetry in tinnitus – in which direction should participants pay attention?

The effects attention has on intensity deviant Mismatch Negativity responses is an unknown factor in basic sensory neuroscience. It would be useful to understand how attention would affect responses to intensity deviants compared to each other (upward vs downward), and compared to other sensory dimensions such as frequency. Overall, previous research indicates that attention may modulate neuronal gain in healthy participants and change the amplitudes of evoked responses, and may mainly affect the responses to regularly repeating (standard) stimuli rather than deviants. Gain may respond differently in participants with tinnitus and/or hyperacusis under the same conditions compared to controls. Overall, results of the passive task condition were consistent with previous research. Auditory attention magnified MMN in response to upward deviants, while visual attention attenuated it in both control and tinnitus groups. However, auditory attention selectively enhanced downward deviant MMN in the tinnitus group (compared to passive attention). Using the auditory attention paradigm may be advantageous in MMN studies on tinnitus/hyperacusis because the observed differences would be particularly large.
Self-Supervised Electrocardiograph De-noising

The electrocardiogram (ECG) records heart-beats and is potentially life-saving. However, the ECG signals (e.g., recorded by the standard ECG monitoring system or the Holter ECG monitoring system) heavily suffered from the noises. Thus, the recorded signals involve meaningful cardiac deflections, other biological waves (e.g., caused by the muscle or electrode movements), and even some noises from the monitoring devices (e.g., the power cables). These noise sources would result in inaccurate analyses of cardiac diseases, thus requiring the ECG de-noising methods in data pre-processing phase before the diagnoses. Previous work provided various ECG de-noising approaches, typically based on some filter algorithms or some wave decomposition algorithms. Most of these approaches did not profoundly consider the ECG signals’ specific data structure, and were not adaptive to the signals recorded by various devices or different skin electrodes. Inspired by the ECG recording theory, we find it available to extract noise information from noisy ECG signals directly. We propose a new ECG de-noising method implemented by the neural network, which de-noise the ECG signals without the supervision of the clean signals. The procedure in the self-supervision is straightforward: we first estimate and simulate the noise signals according to the given noisy ECG signals, and then “subtract” the simulated noises to obtain the de-noised ECG signals by the neural network. Experiments on a public dataset verify that our approach is adaptive to ECG signals from different patients and devices. Also, it is proven that the classification on the ECG signals de-noised by the proposed de-noising methods outperforms those with the traditional de-noising methods.
Dissecting the heat stress altering immune responses and skin microbiota in fish in a recirculating aquaculture system in Singapore

Environmental factors, probiotics and feed additives affect microbiota diversity in fish. Water temperature disrupts the composition and diversity of microbiota, with temperature changes triggering stress and immune responses in fish. In Singapore, water heat treatment is used to control and prevent disease outbreaks in farmed fish. Although gut microbiota responses to heat stress have been reported, little is known about the effects of heat treatment on fish immune responses and fish skin microbiota dynamics. Over a 3-mo interval, we investigated microbiota dynamics and fish immune responses associated with a heat treatment practice in a commercial fish farm with a recirculating aquaculture system (RAS). Tank water temperature was raised to 37-39 °C for 1 hour, every 2 weeks. Tank water and fish microbial communities were analysed by 16S amplicon sequencing, and host molecular expressions were determined by qPCR. We inferred that heat treatment increased stress and immune responses that protected fish from opportunistic infections. However, overreaction to temperature stress can cause dysbiosis of the skin microbiota and death. We also suggested the value of the skin microbiota Pseudomonadota: Bacteroidota (P:B) ratio as a biomarker for aquaculture fish health. IMPORTANCE Aquaculture is an emerging economic activity to supply high-quality animal protein and reduce reliance on wild-caught fish products. Recently, there has been emphasis on intensive aquaculture, using a Recirculating Aquaculture System (RAS). In RAS, management of pathogens/parasites prevalence is a major challenge. Developing practical solutions for producing healthy juveniles in nursery systems will make profound contributions to sustainable aquaculture. In this study, we used an unconventional strategy, exposing juveniles to the pathobiome in the environment, followed by non-lethal heat shock treatments to enhance immunity. Short-term stress induced heat shock proteins that protected fish from opportunistic infections. We concluded that manipulating environmental-microbial-host interactions, together with enhanced functional capacity of fish immune response, has potential for disease control in aquaculture.
Site 516: Rio Grande Rise

Principal results: Hydraulic piston core (HPC) objectives were successfully completed at Site 516 on the upper flanks of the Rio Grande Rise. HPC Holes 516 and 516A penetrated to 183 m sub-bottom, with 85% core recovery and duplication of the uppermost 70 m of the section. Holes 516B, 516C, 516D, and 516E were drilled for instrument development tests and heat flow measurements, and would have continued as rotary holes except for weather and bit loss problems. Rotary drilling at Hole 516F continued to 1270.6 m sub-bottom and recovered a virtually complete sedimentary se-
DESIGN OF X-BAND INTEGRATED FILTERING PYRAMIDAL HORN ANTENNA

An X-band pyramidal horn antenna with a fourth order Chebyshev filtering function is presented in this paper. Four resonators are implemented in linear rectangular waveguide in the filter design. The last stage resonator provides not only resonance pole but also radiation function. To achieve high directivity, a pyramidal horn is attached to the filter output port, with negligible effect on the filter performance. Theoretical results are calculated based on the coupling matrix between the resonators. Finally, a pyramidal horn antenna operating at 10 GHz is designed and fabricated for demonstration. The measured results have found to be in good agreement with the simulated ones.
Comparison of healthcare quality for uninsured and underinsured children through community health centres in Canada and the USA: a scoping review protocol

Introduction Children and youth who are uninsured or underinsured in Canada and the USA have limited options where they can receive healthcare. In both countries, community health centres (CHCs) have been established as a solution to provide quality care to children without adequate insurance, including those who are newcomers or refugees. However, little is known about how well these models deliver paediatric care. Cross-country analysis provides an important viewpoint to identify areas of success and growth. The purpose of this scoping review is to compare quality of care for uninsured and underinsured children through CHCs in the USA and Canada. Methods This scoping review follows the methodological guidelines from the Joanna Briggs Institute Evidence synthesis. The protocol has been registered with the Open Science Framework Registries and can be accessed online. A search will be conducted in electronic databases of peer-reviewed literature (Ovid MEDLINE ALL, CINAHL Complete via EbscoHost, Scopus; Health Business Elite via EbscoHost and Sociological Abstracts via ProQuest) as well as the grey literature. Two reviewers will review all titles and abstracts for inclusion in full-text review. Studies that meet inclusion criteria will be included in full-text review. Data will be extracted into Covidence, using the Donabedian model as a conceptual framework. Findings will be synthesised in a narrative format. Ethics and dissemination As this study only uses publicly available data, ethics approval is not required. Findings will be shared at national and international conferences and published in a peer-reviewed journal. In addition, findings will be prepared into a policy brief or white paper to be shared with relevant policy stakeholders to advocate for a better model of care for marginalised children and youth.