Miracle-dz/UniFAR-FTUs huggingface dataset:
A corn-fermented protein ingredient can be included in early nursey diets without compromising pig growth performance and health status

Abstract In nursery diets, ingredients with high protein content and highly digestible nutrients, such as corn-fermented protein product with added yeast mass (GDDY), can be included as an alternative to common protein sources. This study investigated the dietary inclusion of GDDY as an alternative protein source on growth performance and intestinal health of weaned pigs. A total of 594 weaned pigs (5.7 ± 0.9 kg; 18.5 days of age) were allotted to 36 pens in a randomized incomplete block design. Pens were assigned to one of 4 dietary treatments: CON: a common nursery feeding program; SBM75: CON diet replacing 75% of soybean meal (SBM) with GDDY; FM/ESBM: CON diet without fish meal (FM) and enzyme-treated SBM (ESBM) + GDDY; GDDY50: CON diet replacing 50% of SBM, FM, and ESBM with GDDY. Experimental diets were formulated to meet nutrient requirements of nursery pigs and provided in meal form through four phases during the nursery period. Pig growth performance was assessed on days 7, 14, 21, 28, 42, and 53. Pen fecal score was assessed daily from days 0 to 14, and 3 times per week from days 15 to 35. Intestinal health was assessed based on plasma immunoglobulin A (IgA) concentration and the differential sugar absorption test. The total tract digestibility of dry matter (DM), crude protein (CP), gross energy (GE), and phosphorus was also evaluated. From days 0 to 7 and days 7 to 14, dietary treatment had no effect (P > 0.05) on BW, ADG, and ADFI. For the rest of the experimental period, ADG and ADFI were greater (P < 0.05) in pigs fed CON in comparison with those fed SBM75 and GDDY50 and did not differ from pigs fed FM/ESBM. Pigs fed GDDY50 tended (P = 0.082) to have greater serum IgA concentration on day 20 when compared with SBM75 and FM/ESBM pigs. There were no differences among dietary treatments for DM, CP, and GE digestibility. Phosphorus digestibility was higher in FM/ESBM (P < 0.05) compared with SBM75 and GDDY50. These results supported the hypothesis that GDDY can be incorporated in nursery pig diets during the first couple weeks after weaning without affecting growth performance. However, in the late nursery period, inclusion levels starting at 14% can compromise performance.
28 de septiembre

Lafrancaise, Naples Lafrancaise Fecha : 28/09/2007 Sombra : 104,5cm Angulo : 46°15' Naples, Florida, USA Fecha : 28/09/2007 Sombra : 62,5cm Angulo : 35°00' Nuestra escuela es una empresa publica, A - valorados escuela. Hay 24 ninos en esta clase, y 770 ninos en la escuela. Tenemos un gran problema y maravilloso programa de los profesores de toda indole, incluso por el arte! Pelican Marsh cuenta con un programa de noticias por la manana que todos los maestros de la melodia de sus televisores para (.)
A Nonlinear Adaptive Weight-Based Mutated Whale Optimization Algorithm and Its Application for Solving Engineering Problems

Whale optimization algorithm (WOA) is a swarm-based optimization algorithm with exceptional performance and significant originality. In this study, a novel variant of WOA called nonlinear adaptive weight-based mutated WOA (NAWMWOA) is proposed to overcome the shortcomings of original WOA such as easily falling into local optimum and slow convergence speed. In detail, the proposed NAWMWOA includes three novel strategies as comparing with original WOA. Firstly, a nonlinear convergence factor is embedded into the original WOA to balance exploration and exploitation ability. The second improvement is an adaptive weight strategy, which can enhance the exploratory searching trends and improve the solution accuracy. Moreover, the thirdly proposed hybrid mutation strategy has the function of increasing the accuracy and jumping out of the local optimum. The combination of the three strategies significantly improve convergence efficiency and search accuracy of original WOA. To verify the remarkable performance of the proposed NAWMWOA, a series of illustrious WOA variants and state-of-the-art intelligent algorithms is compared with the NAWMWOA on 37 benchmark functions and three typical engineering problems. The details of experimental and statistics results illustrate that the presented NAWMWOA has higher convergence efficiency and better solution accuracy. As a conclusion, the proposed NAWMWOA is a competitive and outstanding algorithm that can effectively solve optimization problems in practical engineering.
Mammoth Extinction: Two Continents and Wrangel Island

A harvest of 300 radiocarbon dates on extinct elephants (Proboscidea) from the northern parts of the New and Old Worlds has revealed a striking difference. While catastrophic in North America, elephant extinction was gradual in Eurasia (Stuart 1991), where straight-tusked elephants (Palaeoloxodon antiquus) vanished 50 millennia or more before woolly mammoths (Mammuthus primigenius). The range of the woolly mammoths started shrinking before 20 ka ago (Vartanyan et al. 1995). By 12 ka bp, the beasts were very scarce or absent in western Europe. Until the dating of Wrangel Island tusks and teeth (Vartanyan, Garrutt and Sher 1993), mammoths appeared to make their last stand on the Arctic coast of Siberia ca. 10 ka bp. The Wrangel Island find of dwarf mammoths by Sergy Vartanyan, V. E. Garrut and Andrei Sher (1993) stretched the extinction chronology of mammoths another 6 ka, into the time of the pharaohs.
AN ISLAMIC SPIRIT FOR BUSINESS ETHICS AND LEGAL FRAMEWORK OF FINTECH PEER TO PEER LENDING: Why Does Indonesia Need It?

The growth of Fintech Peer-to-Peer (P2P) lending in Indonesia is one of the supports for national economic development. The positive growth of this financial sector is not supported by proportional rules, resulting in the practices of business ethics violation which is detrimental to society. To overcome these problems, the spirit of Islam can be the basis for determining ethical and business measures into a better legal framework for Fintech P2P Lending. This article applies a normative legal research method using a conceptual approach and legislation relevant to the theme of the study. The research results indicate that Fintech P2P Lending in Indonesia needs to be regulated in a qualified legal framework because the existing rules have not been able to solve unethical actions of businessmen. The business concept in Islam also accommodates ethical issues that must be applied in business activities as a harmless commerce spirit. This Islamic spirit can be used as a source of material law in determining a clear legal framework to uphold Fintech P2P Lending business ethics so as not to harm the Indonesian people.Pertumbuhan fintech peer-to-peer (P2P) lending di Indonesia merupakan salah satu penunjang pembangunan ekonomi nasional. Pertumbuhan positif sektor keuangan ini tidak diikuti dengan aturan yang proporsional sehingga menimbulkan praktik-praktik yang melanggar etika bisnis dan sangat merugikan masyarakat. Untuk mengatasi permasalahan tersebut, semangat Islam dapat menjadi landasan untuk menentukan langkah-langkah etis dan bisnis ke dalam kerangka hukum fintech P2P lending yang lebih baik. Artikel ini menggunakan metode penelitian hukum normatif dengan menggunakan pendekatan konseptual dan peraturan perundang-undangan yang relevan dengan tema penelitian. Hasil penelitian dalam artikel ini menunjukkan bahwa fintech P2P Lending di Indonesia perlu diatur dalam kerangka hukum yang mumpuni karena aturan yang ada belum mampu mengatasi tindakan tidak etis dari para pelaku bisnis. Konsep bisnis dalam Islam juga mengakomodir persoalan etika yang harus diterapkan dalam kegiatan bisnis sebagai spirit perdagangan yang tidak merugikan. Semangat keislaman ini dapat dijadikan sebagai sumber hukum materil dalam menentukan kerangka hukum yang jelas untuk menegakkan etika bisnis fintech P2P lending agar tidak merugikan masyarakat Indonesia.
Mantle Metasomatism at the Edge of a Retreating Subduction Zone: Late Neogene Lamprophyres from the Island of Kos, Greece

The island of Kos at the eastern end of the South Aegean Volcanic Arc hosts numerous late Neogene amphibole- and mica-bearing lamprophyres. The Sr and Nd isotope compositions of these mantle-derived magmatic rocks correlate negatively, extending from the undepleted end of the mantle array towards values typical for continental crust. The crust-like signature is linked to the addition of subducted Mediterranean sediments, which dominate the Pb isotopic composition of all lamprophyres. The mantle endmember of the Sr–Nd isotope mixing array is strongly enriched in incompatible trace elements and shows anorogenic afﬁnities. Whole-rock geochemistry indicates that the lamprophyres originate from depleted lithospheric mantle above the Hellenic subduction zone that was modiﬁed by (1) K-rich silicic partial melts or supercritical ﬂuids from subducted metasediments and (2) melts that originate from the asthenosphere below the subducting slab. The ﬁrst metasomatic component formed phlogopite–orthopyroxene-rich veins, whereas the second component formed amphibole-bearing clinopyroxenites. Subsequent melting preferentially affected these enriched domains. Variable dilution by contributions from ambient peridotite and mixing between the two components caused the large chemical variation observed in the lamprophyres. The asthenosphere-derived component represents an incipient melt with a carbonatite-like trace element signature (e.g. superchondritic Nb/Ta and Zr/Hf; low Ti/Eu). This metasomatic agent probably was introduced into the mantle wedge along ruptures in the slab of the retreating Hellenic subduction zone. Lamprophyres dominated by the sediment signature have isotopic and chemical similarities to basaltic rocks erupted along the South Aegean Volcanic Arc. The much stronger enrichment in incompatible trace elements of the lamprophyres is related to only minor dilution by melts from the ambient mantle. Partial melting in the lithospheric mantle is attributed to extensional tectonics, probably during a stage of rapid slab rollback, with a limited availability of ﬂuid as a ﬂuxing agent. Lamprophyre emplacement occurred along sinistral en echelon structures in a crustal-scale shear zone, which separates Anatolia from the faster extending Aegean back-arc basin.
The microbial role in carbon cycling within seagrass sediments

Seagrasses are an important feature of coastal systems worldwide, capable of fixing significant amounts of carbon dioxide from the atmosphere into cellular material, potentially helping to alleviate rising carbon dioxide levels. However, the capacity of seagrass beds to act as carbon sinks is largely dependent on the amount of organic matter accumulated within the sediments following transformations by the microbial community. The microbial role in carbon cycling within seagrass sediments has been poorly researched, most likely because the importance of marine microbes in ocean cycling processes was only recently recognized, due to key advancements in molecular biology. This review examines carbon sources within seagrass sediments, their utilization by the microbial community, and their ultimate fates, in order to elucidate current understanding of carbon cycling in seagrass sediments. Future research should incorporate molecular techniques to further establish the microbial role in carbon cycling within seagrass sediments, and ultimately ascertain the capacity of seagrass beds to act as sinks of organic matter.
USE OF TIME-TEMPERATURE EVALUATIONS IN DETECTING THE RESPONSIBLE VEHICLE AND CONTRIBUTING FACTORS OF FOODBORNE DISEASE OUTBREAKS1

An investigation of an outbreak of Clostridium perfringens foodborne illness indicated that turkey or dressing prepared in a school kitchen was responsible. When turkey was again prepared in the kitchen, a bacteriological survey and a time-temperature evaluation were made of the thawing, cooking, chilling, and reheating to which the turkey, stock, or dressing were subjected. During thawing of 22-lb. turkeys in plastic wrappers and in paper bags at room temperature for 18 hr, neither internal nor surface temperatures reached a level at which C. perfringens could grow. Cooking the turkeys in a steamer or in a pot of boiling water raised internal temperatures to a level lethal to vegetative cells. The stock (in gallon jars and a large rectangular pan) and deboned meat (in similar pan) were stored overnight in a reach-in refrigerator. During storage the temperature of both were within a range so that C. perfringens spores could germinate and its vegetative cells multiply for 7–9 hr. The stock was later used i.
The Economic Advantage: Assessing the value of climate-change actions in agriculture

 The ingredients of a strong economic assessment for NDCs and other climate change plans for agriculture include: policy mainstreaming, iterative planning, a balance of project-level and farm-level assessment of costs and benefits, understanding of how costs and benefits are distributed, and appraisal of drivers of behavioural change, economic incentives and the enabling environment for farmers and other private-sector actors.
Performance of Regional Integrated Environment Modeling System (RIEMS) in the Simulation of Surface Air Temperature over East Asia

Abstract Regional climate models (RCMs) have the potential for more detailed surface characteristic and mesoscale modeling results than general circulation models (GCMs). These advantages have drawn significant focus on RCM development in East Asia. The Regional Integrated Environment Modeling System, version 2.0 (RIEMS2.0), has been developed from an earlier RCM, RIEMS1.0, by the Key Laboratory of Regional Climate-Environment for Temperate East Asia (RCE-TEA) and Nanjing University. A numerical experiment covering 1979 to 2008 (simulation duration from 1 January 1978 to 31 December 2008) with a 50-km spatial resolution was performed to test the ability of RIEMS2.0 to simulate long-term climate and climate changes in East Asia and to provide a basis for further development and applications. The simulated surface air temperature (SAT) was compared with observed meteorological data. The results show that RIEMS2.0 simulation reproduced the SAT spatial distribution in East Asia but that it was underestimated. The simulated 30-year averaged SAT was approximately 2.0°C lower than the observed SAT. The annual and interannual variations in the averaged SAT and their anomalies were both well reproduced in the model. A further analysis of three sub-regions representing different longitudinal ranges showed that there is a good correlation and consistency between the simulated results and the observed data. The annual variations, interannual variations for the averaged SAT, and the anomalies in the three sub-regions were also captured well by the model. In summary, RIEMS2.0 shows stability and does well both in simulating the long-term SAT in East Asia and in expressing sub-regional characteristics.
Transarterial Radioembolization (TARE) in Patients with Hepatocellular Carcinoma: A Comparison of Palliative with Bridging-to-Transplant Concepts

Simple Summary Liver transplantation (LT) is the best potentially curative treatment for unresectable, early-stage hepatocellular carcinoma (HCC) in cirrhotic patients. Bridging-to-transplant therapies, including transarterial radioembolization (TARE), are performed to delay tumor progression until the LT can be performed but also offer potential benefits regarding post-transplant progression-free survival. This study confirms the good results of bridging-to-transplant TARE, of LT as a curative treatment of HCC, and also shows the importance of TARE in the palliative, multimodal treatment of patients with HCC. Abstract We investigated transarterial radioembolization (TARE) as a palliative measure and bridging-to-transplant therapy in hepatocellular carcinoma (HCC) patients. A total of 167 patients (50 bridging, 117 palliative) with 245 TARE procedures were assessed. Fourteen patients underwent subsequent liver transplantation (LT). Patients undergoing LT exhibited significantly prolonged progression-free survival (PFS) compared to those with bridging-without-transplant (p = 0.033). No significant differences were observed between patients with bridging-without-transplant and palliative cases (p = 0.116). Median overall survival (OS) post-TARE was 16.6 months, with estimated OS rates at 6/12 months of 82.0%/60.5%, respectively. Patients who underwent LT demonstrated statistically significantly longer OS compared to those with bridging-without-transplant (p = 0.001). No marked outcome distinctions were found between bridging-without-transplant and palliative groups. The findings underscored the superiority of LT over alternative treatments. TARE served as an important component in non-LT scenarios, allowing for subsequent therapeutic options. The study reflected the highly variable and complex situations of patients with HCC, emphasizing the need for further investigations to define an optimal multimodal approach.
Nanozyme-assisted amplification-free CRISPR/Cas system realizes visual detection

The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR associated) system has proven to be a powerful tool for nucleic acid detection due to its inherent advantages of effective nucleic acid identification and editing capabilities, and is therefore known as the next-generation of molecular diagnostic technology. However, the detection technologies based on CRISPR/Cas systems require preamplification of target analytes; that is, target gene amplification steps through isothermal amplification or PCR before detection to increase target analyte concentrations. This creates a number of testing limitations, such as extended testing time and the need for more sophisticated testing instruments. To overcome the above limitations, various amplification-free assay strategies based on CRISPR/Cas systems have been explored as alternatives, which omit the preamplification step to increase the concentrations of the target analytes. Nanozymes play a pivotal role in enhancing the sensitivity of CRISPR-based detection, enabling visual and rapid CRISPR assays. The utilization of nanozyme exceptional enzyme-like catalytic activity holds great promise for signal amplification in both electrochemical and optical domains, encompassing strategies for electrochemical signal sensors and colorimetric signal sensors. Rather than relying on converting a single detection target analyte into multiple analytes, these methods focus on signal amplification, the main mechanism of which involves the ability to form a large number of reporter molecules or to improve the performance of the sensor. This exploitation of nanozymes for signal amplification results in the heightened sensitivity and accuracy of detection outcomes. In addition to the strategies that improve sensor performance through the application of nanozymes, additional methods are needed to achieve visual signal amplification strategies without preamplification processes. Herein, we review the strategies for improving CRISPR/Cas systems that do not require preamplification, providing a simple, intuitive and preamplification-free CRISPR/Cas system detection platform by improving in-system one-step amplification programs, or enhancing nanozyme-mediated signal amplification strategies.
Multiple Regulatory Signals and Components in the Modulation of Bicarbonate Transporters

Bicarbonate transporters are responsible for the appropriate flux of bicarbonate across the plasma membrane to perform various fundamental cellular functions. The functions of bicarbonate transporters, including pH regulation, cell migration, and inflammation, are highlighted in various cellular systems, encompassing their participation in both physiological and pathological processes. In this review, we focused on recently identified modulatory signaling components that regulate the expression and activity of bicarbonate transporters. Moreover, we addressed recent advances in our understanding of cooperative systems of bicarbonate transporters and channelopathies. This current review aims to provide a new, in-depth understanding of numerous human diseases associated with the dysfunction of bicarbonate transporters.
Network analysis of multimorbidity and health outcomes among persons with spinal cord injury in Canada

Introduction Multimorbidity, defined as the coexistence of two or more health conditions, is common in persons with spinal cord injury (SCI). Network analysis is a powerful tool to visualize and examine the relationship within complex systems. We utilized network analysis to explore the relationship between 30 secondary health conditions (SHCs) and health outcomes in persons with traumatic (TSCI) and non-traumatic SCI (NTSCI). The study objectives were to (1) apply network models to the 2011–2012 Canadian SCI Community Survey dataset to identify key variables linking the SHCs measured by the Multimorbidity Index-30 (MMI-30) to healthcare utilization (HCU), health status, and quality of life (QoL), (2) create a short form of the MMI-30 based on network analysis, and (3) compare the network-derived MMI to the MMI-30 in persons with TSCI and NTSCI. Methods Three network models (Gaussian Graphical, Ising, and Mixed Graphical) were created and analyzed using standard network measures (e.g., network centrality). Data analyzed included demographic and injury variables (e.g., age, sex, region of residence, date, injury severity), multimorbidity (using MMI-30), HCU (using the 7-item HCU questionnaire and classified as “felt needed care was not received” [HCU-FNCNR]), health status (using the 12-item Short Form survey [SF-12] Physical and Mental Component Summary [PCS-12 and MCS-12] score), and QoL (using the 11-item Life Satisfaction questionnaire [LiSAT-11] first question and a single item QoL measure). Results Network analysis of 1,549 participants (TSCI: 1137 and NTSCI: 412) revealed strong connections between the independent nodes (30 SHCs) and the dependent nodes (HCU-FNCNR, PCS-12, MCS-12, LiSAT-11, and the QoL score). Additionally, network models identified that cancer, deep vein thrombosis/pulmonary embolism, diabetes, high blood pressure, and liver disease were isolated. Logistic regression analysis indicated the network-derived MMI-25 correlated with all health outcome measures (p <0.001) and was comparable to the MMI-30. Discussion The network-derived MMI-25 was comparable to the MMI-30 and was associated with inadequate HCU, lower health status, and poor QoL. The MMI-25 shows promise as a follow-up screening tool to identify persons living with SCI at risk of having poor health outcomes.
EFFECT OF NITROGEN LEVELS ON DIFFERENT VARIETIES OF FODDER TEOSINTE (EUCHLAENA MAXICANA (L.) SCHROD) IN NEW ALLUVIAL ZONE OF WEST BENGAL

nitrogen levels on different varieties of teosinte [Euchlaena maxicana (L.) Schrod] in new alluvial zone of West Bengal. The soil of the experimental field was sandy loam alluvial soil. The soil was neutral in reaction pH 6.8, oxydizable organic carbon 0.43 per cent, total nitrogen 0.047 per cent, available phosphorus 46 kg/ha and available potassium 241 kg/ha. The experiment was laid out in factorial randomized block design with 12 treatments and three replications. The treatments were first factor teosinte variety with five levels viz., JHT04-1, JHT-04-2, JHT-04-3, TL-1 and Improved Sirsa and second factor nitrogen with three levels viz., N 30 , N 60 and N 90 . The significantly highest green fodder yield of 403.13, 447.92 and 473.07 q/ha was recorded with variety TL-1 treatment, N 90 treatment and combined effect of TL-1 × N 90 treatment, respectively. The increasing nitrogen levels increased plant height, plant population, dry matter yield and green fodder yield. The increasing trend of crude protein was observed with increasing nitrogen levels. Among the varieties, TL-1 and JHT-043 performed well in all aspects in new alluvial zone of West Bengal.