Miracle-dz/UniFAR-FTUs huggingface dataset:
Reporting Incidents in the Psychiatric Intensive Care Unit

Abstract To evaluate the characteristics of the reported workplace violence in a psychiatric intensive care unit (PICU) by analyzing an electronic hospital incident reporting system (IRS). One hundred thirty reports were retrieved from January 2017 to June 2020, referring to assaults committed by patients (71% males) with an average age of 29.8 years (SD, 14.9). The most frequent psychiatric diagnosis was a neurodevelopmental disorder (33%). Physical aggression (84%) was more frequent than the other types of aggression. Nurses and unlicensed assistive personnel were the most frequent victims (65%). Aggressions were more frequent on Friday (18%) and between 4 p.m. and 8 p.m. (35%). A total of 64.9% of the incidents happened in the first 5 days of hospitalization. A significant association between physical aggression and diagnosis of neurodevelopmental disorder emerged. IRS could be helpful to identify high-risk patient groups and develop clinical strategies to reduce adverse events in clinical practice.
The pro‐apoptotic Bax gene modifies susceptibility to craniofacial dysmorphology following gastrulation‐stage alcohol exposure

During early development, alcohol exposure causes apoptotic cell death in discrete regions of the embryo which are associated with distinctive patterns of later‐life abnormalities. In gastrulation, which occurs during the third week of human pregnancy, alcohol targets the ectoderm, the precursor of the eyes, face, and brain. This midline tissue loss leads to the craniofacial dysmorphologies, such as microphthalmia and a smooth philtrum, which define fetal alcohol syndrome (FAS). An important regulator of alcohol‐induced cell death is the pro‐apoptotic protein Bax. The current study determines if mice lacking the Bax gene are less susceptible to the pathogenic effects of gastrulation‐stage alcohol exposure.
Sexual Abuse as a Risk Factor for Opioid Misuse in Pregnancy

ABSTRACT The purpose of this study was to identify a potential relationship between childhood sexual abuse and opioid misuse in pregnancy and to illustrate the need for better integration and collaboration between the medical and psychological disciplines to combat the opioid crisis. We sampled 93 pregnant women at a high-risk pregnancy clinic within a university medical center who were in their second trimester or beyond. Fifty-five women were considered high-risk due to opioid misuse and 38 women were considered high-risk due to medical reasons other than drug use. Our findings reveal both presence of and severity of sexual abuse were significantly associated with opioid misuse in pregnancy, while physical abuse, emotional abuse, and neglect were not. While childhood sexual abuse is a significant risk factor for opioid misuse in pregnancy, most doctors do not feel comfortable asking about trauma history. A public health approach to opioid misuse in pregnancy must consider how “diseases of despair” disproportionately impact women with limited access to adequate psychological and medical care. A preventative model of care, which targets screenings for ACEs in primary care and gynecological visits may help decrease the impact of sexual abuse.
Heat Therapy Can Improve Hepatic Mitochondrial Function and Glucose Control

Similar to the effects of exercise, improvements in hepatic mitochondrial adaptations and glucose control occur in response to heat treatment. This review proposes the novel hypothesis that heat can be used as an alternative therapy to exercise to improve hepatic mitochondrial function and glucose regulation in patients with nonalcoholic fatty liver disease. Although exercise has proven benefits in treating nonalcoholic fatty liver disease, barriers to exercise in the majority of patients necessitate an alternative method of treatment.
Wide-b-and circularly polarised slot antenna by using artificial transmission line

A novel single-feed wide band planar single layer circularly polarised (CP) slot antenna is presented. This low cost slot antenna consists of an L-shaped feeding stub with metamaterial inspired complementary split ring resonator (MICSRR) and a wide 45° rotated symmetric square aperture. Broadband impedance and CP radiation bandwidth (BW) is achieved by using a novel artificial exciting stub with defecting CSRRs on it. By controlling the excitation phase of L-shaped stub, a desirable circular polarisation can be generated and both impedance and CP BWs are considerably increased by up to 89%. The operating frequency ranges in S/C band about 1.5 octaves from 2.4–6.22 GHz that covers most of the commercial wireless communication systems, such as WLAN (IEEE 802.11 (2.4/3.6/4.9/5/5.9 GHz)), LTE and WiMAX (2.5/3.5/5.8 GHz). The measured BWs of 3-dB axial ratio and voltage standing wave ratio < 2 are around 91% (2.4–6.4 GHz) and 89% (2.4–6.22 GHz), respectively. The measured boresight gain is less than 6 dBic over the CP BW.
A novel, de novo intronic variant in POGZ causes White–Sutton syndrome

White–Sutton syndrome (WHSUS), which is caused by heterozygous pathogenic variants in POGZ, is characterized by a spectrum of intellectual disabilities and global developmental delay with or without features of autism spectrum disorder. Additional features may include hypotonia, behavioral abnormalities, ophthalmic abnormalities, hearing loss, sleep apnea, microcephaly, dysmorphic facial features, and rarely, congenital diaphragmatic hernia (CDH). We present a 6‐year‐old female with features of WHSUS, including CDH, but with nondiagnostic clinical trio exome sequencing. Exome sequencing reanalysis revealed a heterozygous, de novo, intronic variant in POGZ (NM_015100.3:c.2546‐20T>A). RNA sequencing revealed that this intronic variant leads to skipping of exon 18. This exon skipping event results in a frameshift with a predicted premature stop codon in the last exon and escape from nonsense‐mediated mRNA decay (NMD). To our knowledge, this case is the first case of WHSUS caused by a de novo, intronic variant that is not near a canonical splice site within POGZ. These findings emphasize the limitations of standard clinical exome filtering algorithms and the importance of research reanalysis of exome data together with RNA sequencing to confirm a suspected diagnosis of WHSUS. As the sixth reported case of CDH with heterozygous pathogenic variants in POGZ and features consistent with WHSUS, this report supports the conclusion that WHSUS should be considered in the differential diagnosis for patients with syndromic CDH.
SMART: An Open-Source Extension of WholeBrain for Intact Mouse Brain Registration and Segmentation

Abstract Mapping immediate early gene (IEG) expression across intact mouse brains allows for unbiased identification of brain-wide activity patterns underlying complex behaviors. Accurate registration of sample brains to a common anatomic reference is critical for precise assignment of IEG-positive (“active”) neurons to known brain regions of interest (ROIs). While existing automated voxel-based registration methods provide a high-throughput solution, they require substantial computing power, can be difficult to implement and fail when brains are damaged or only partially imaged. Additionally, it is challenging to cross-validate these approaches or compare them to any preexisting literature based on serial coronal sectioning. Here, we present the open-source R package SMART (Semi-Manual Alignment to Reference Templates) that extends the WholeBrain R package framework to automated segmentation and semi-automated registration of intact mouse brain light-sheet fluorescence microscopy (LSFM) datasets. The SMART package was created for novice programmers and introduces a streamlined pipeline for aligning, registering, and segmenting LSFM volumetric datasets across the anterior-posterior (AP) axis, using a simple “choice game” and interactive menus. SMART provides the flexibility to register whole brains, partial brains or discrete user-chosen images, and is fully compatible with traditional sectioned coronal slice-based analyses. We demonstrate SMART’s core functions using example datasets and provide step-by-step video tutorials for installation and implementation of the package. We also present a modified iDISCO+ tissue clearing procedure for uniform immunohistochemical labeling of the activity marker Fos across intact mouse brains. The SMART pipeline, in conjunction with the modified iDISCO+ Fos procedure, is ideally suited for examination and orthogonal cross-validation of brain-wide neuronal activation datasets.
Kefir milk consumption decreases sperm alterations due to the high‐fat diet in adult male rats

Over the past decades, an increase of male infertility through the decrease of sperm count has been noted. It has been suggested that environmental factors and lifestyle could a negative impact over sperm quality. Among these factors, the consumption of foods high in fat, which leads to overweight and obesity, can negatively influence fertility. The present study was designed to highlight the protective effect of Kefir, natural probiotic, against the decline in sperm quality related to fat high diet. Thirty adult rats were divided into four groups: Control (1 ml/100 g of body weight (bw) of semi‐shimmed cow milk), KM (1 ml/100 g bw of Kefir milk), HFD (1 ml/100 g bw of semi‐shimmed cow milk + high‐fat diet) and KM/HFD (1 ml/100 g bw Kefir milk + high‐fat diet). After 60 days of treatment, sperm quality, biochemical assays of lipids profil, blood cell count and histological examination in testis were assessed. The results described an improved of sperm density (64.28 106 ml vs 54.14 106 ml), viability (70.50% vs 55.33%), mobility (65.40% vs 63.60%) and morphological abnormalities (52% vs 25%) in the KM/HFD group compared to HFD group. In the same group, the lipid profil (Triglycerides (128.39 mg/dl vs 102.85 mg/dl), C‐LDL (13.65 mg/dl vs 15.32 mg/dl) and C‐HDL (23.21 mg/dl vs 19.15 mg/dl)) was corrected compared to HFD group. The histological observation of testis revealed a normal spermatogenesis compared to seminiferous tubules of HFD group, which showed a serious disruption and damage of testicular epithelium exerted by the high‐fat diet. These findings corroborated the previous beneficial effect of Kefir and brought new insights into its beneficial effect against deteriorated spermatogenesis in obese adult rats.
Direct oral anticoagulants versus warfarin for secondary prevention of cerebral infarction and bleeding in older adults with atrial fibrillation

Direct oral anticoagulants (DOACs) have been used for both primary and secondary prevention of cerebral infarction in older patients with atrial fibrillation (AF). However, whether DOACs are more effective and safer than warfarin for secondary prevention of cerebral infarction in older patients with AF remains unclear.
Visual Assistance in Development and Validation of Bayesian Networks for Clinical Decision Support

The development and validation of Clinical Decision Support Models (CDSM) based on Bayesian networks (BN) is commonly done in a collaborative work between medical researchers providing the domain expertise and computer scientists developing the decision support model. Although modern tools provide facilities for data-driven model generation, domain experts are required to validate the accuracy of the learned model and to provide expert knowledge for fine-tuning it while computer scientists are needed to integrate this knowledge in the learned model (hybrid modeling approach). This generally time-expensive procedure hampers CDSM generation and updating. To address this problem, we developed a novel interactive visual approach allowing medical researchers with less knowledge in CDSM to develop and validate BNs based on domain specific data mainly independently and thus, diminishing the need for an additional computer scientist. In this context, we abstracted and simplified the common workflow in BN development as well as adjusted the workflow to medical experts needs. We demonstrate our visual approach with data of endometrial cancer patients and evaluated it with six medical researchers who are domain experts in the gynecological field.
Recurrent aphthous stomatitis: A comprehensive review and recommendations on therapeutic options

Recurrent aphthous stomatitis (RAS) is a common chronic disease in the oral mucosa that affects about 20% of the population. It is characterized by solitary or multiple, recurrent, small ulcers with erythematous haloes and yellow/gray floors. RAS can be managed through a wide variety of preventative measures and therapies, intending to reduce ulcer pain, stimulate ulcer healing, and/or prevent ulcer recurrence. First‐line treatment options include topical medications in the form of corticosteroids (triamcinolone acetonide), anti‐inflammatory drugs (amlexanox), antibiotics (doxycycline), and antiseptics (lidocaine). In more severe cases of RAS where local treatment is insufficient, systemic drugs in the form of corticosteroids (prednisone), immunomodulatory drugs (thalidomide), and antibiotics/antimicrobials (clofazimine) can prove effective. This review will summarize current treatment options for RAS with discussion of prevention, topical measures, natural treatments, systemic therapies, and new potential therapies. Furthermore, this review will provide recommendations on therapeutic options for RAS based on disease severity and patient circumstances.
Preparing for selection success: Socio‐demographic differences in opportunities and obstacles

There is a growing drive to improve the heterogeneity of medical school cohorts. However, those from lower socio‐economic groups remain under‐represented. Understanding the methods used by applicants to prepare for medical school selection, and the challenges they face with respect to opportunities and access, may provide important insights to this lack of diversity. This research considered the influence of socio‐demographic background on preparation for medical school selection and on the successful offer of a place.
Operational tolerance is not always permanent: A 10‐year prospective study in pediatric liver transplantation recipients

Immunosuppression withdrawal can be safely performed in select liver transplantation recipients, but the long‐term outcomes and sustainability of tolerance have not been well studied. We completed a 10‐year prospective, observational study of 18 pediatric liver transplantation recipients with operational tolerance to (1) assess the sustainability of tolerance over time, (2) compare the clinical characteristics of patients who maintained versus lost tolerance, (3) characterize liver histopathology findings in surveillance liver biopsies; and (4) describe immunologic markers in patients with tolerance. Comparator patients from two clinical phenotype groups termed “stable” and “nontolerant” patients were used as controls. Of the 18 patients with operational tolerance, the majority of patients were males (n = 14, 78%) who were transplanted for cholestatic liver disease (n = 12, 67%). Median age at transplantation was 1.9 (range, 0.6–8) years. Median time after transplantation that immunosuppression had been discontinued was 13.1 (range, 2.9–22.1) years. As many as 11 (61%) maintained tolerance for a median of 10.4 (range, 1.9–22.1) years, whereas 7 (39%) lost tolerance after a median of 3.2 (range, 1.5–18.6) years. Populations of T regulatory cells (%CD4+ CD25hi CD127lo) were significantly higher in patients with tolerance (p = 0.02). Our results emphasize that spontaneous operational tolerance is a dynamic and nonpermanent state. It is therefore essential for patients who are clinically stable off immunosuppression to undergo regular follow‐up and laboratory monitoring, as well as surveillance biopsies to rule out subclinical rejection.
Glycolytic oscillations in HeLa cervical cancer cell spheroids

Previous studies have unravelled glycolytic oscillations in cancer cells, such as HeLa cervical and DU145 prostate cancer cells, using a monolayer culture system. Here, we demonstrate glycolytic oscillations in HeLa cervical cancer cell spheroids. Experiments revealed that a small number of HeLa cells in spheroids exhibited heterogeneous oscillations with a higher frequency than those in monolayers. Model analyses and our previous experiments indicated that the higher frequencies of oscillations in spheroids were mostly due to the increase in glycolytic enzyme activity in the cells, and to the decrease in glucose concentration by diffusional transport of glucose from the surface to inside the spheroids, as well as the increase in cell density through spheroid formation. These results and our previous studies imply that more malignant cancer cells tend to exhibit glycolytic oscillations with higher frequencies than less malignant cells. Adjacent cells in spheroids oscillated within a 10% difference in frequency, but did not synchronize with each other. This suggests that weak cell‐to‐cell interactions might exist among HeLa cells connected with cadherins in the spheroid microenvironment; however, the interactions were not strong enough to induce synchronization of glycolytic oscillations.
Mikrobielle Probleme in der Papierfabrikation. Teil 3. Monitoring

The early recognition of problems caused by microorganisms and efficiency control of countermeasures require representative monitoring of deposit formation. Current procedures include slime boards or automated measurement of oxygen consumption. Ideally information should be acquired on line, continously, and in real time. Frictional resistance, which can be measured as pressure drop over a tube section, matches these criteria to a certain extent. A new method is presented : the differential turbidity measurement (DTM). Two optical sensors are combined, one of them being cleaned periodically. Subtraction of the data reveals the contribution of the deposit on the measuring window of the uncleaned probe. With this device, the effects of a conventional slimicide and a product containing peracetic acid with improved environmental characteristics could be demonstrated.
Robust tracking of bicycle crank angles using magneto-inertial sensors, domain constraints and functional frame alignment techniques

The crank angle is an important outcome in biomechanical analyses of cycling. Wireless inertial and magnetic measurement systems are unobtrusive and have the potential to measure crank angles more advantageously than ergometers, encoders or cameras. However, magnetic field disturbances and large centripetal accelerations during pedaling introduce tracking errors. The aim of this study was to validate two magnetometer-free sensor-to-body frame alignment methods for tracking the bicycle crank angle using wireless inertial and magnetic measurement systems. A passive complementary filter is presented for tracking the crank angle using an inertial and magnetic measurement system mounted on the bicycle frame and another on the crank arm. Sensor-to-body frame alignment is performed for both inertial and magnetic measurement systems using functional calibration techniques that do not require magnetometer measurements. The filter also performs dynamic tracking of the crank arm inertial and magnetic measurement system without magnetometer data by exploiting domain constraints and compensating for centripetal accelerations. The filter was validated at a slow, medium and fast pedaling cadence using stereophotogrammetry. The filter produced absolute errors of 1.3° ± 0.9° or less in all three tests. In contrast, large and variable absolute errors (11.6° ± 7.6°, 14.2° ± 10.7° and 14.0° ± 10.2°, respectively) were found with a standard passive complementary filter using a traditional static pose calibration that relies on magnetometer data. The proposed filter operated with low and consistent errors despite the presence of magnetic interferences, whereas traditional magnetometer-based approaches produced unacceptable results. This study contributes toward the ultimate goal of outdoor cycling analysis using inertial and magnetic measurement system technology by accomplishing magnetometer-free frame alignment and centripetal acceleration compensation when tracking crank angles.
Performance analysis of aodv, dsdv and aomdv using wimax in NS-2

WiMAX(IEEE 802.16) technology empowers ubiquitous delivery of wireless broadband facility for fixed and mobile users. WiMAX standard describes numerous physical and MAC layer characteristics. Here, an attempt is made to implement some of these physical and MAC layer structures including the mobility extension 802.16e. NS2 (Network Simulator-2) is chosen as the simulator to implement these features as NS2 provides suitable library to simulate network scenario. The performance of the simulated module is analyzed by running AODV, DSDV and AOMDV routing protocols on a wired-cum-wireless WiMAX scenario. The throughput for each routing protocol is calculated for varying number of mobile nodes or subscriber stations.
COMPARISON OF SIMULATION METHODOLOGIES FOR SUCTION AND DISCHARGE SYSTEMS

Suction and discharge systems have an important role in the efficiency of reciprocating machines. Several authors have dedicated attention to this subject, proposing different simulation methodologies to solve the pulsating flow that prevails in such systems. In this work, two numerical approaches are applied to predict the unsteady gas flow through the suction muffler of a reciprocating refrigeration compressor: a linear acoustic method and a finite volume model. The acoustic model considers mufflers as Helmholtz resonators and requires empirical loss coefficients to bring about pressure oscillation damping. In the finite volume methodology, the governing equations are integrated over control volumes placed along the solution domain, resulting in a system of algebraic equations that is then solved. Both models are implemented into a computaional code written to simulate the dynamic behavior of refrigeration compressors. Numerical results for pressure pulsation in the suction chamber, compressor capacity and compressor consuption are compared with experimental data to assess each model capability. Although the present paper is concerned with suction systems of refrigeration compressors, the analysis can be extended to other applications, such as IC engines.
A Systematic Review of Empirical Emergency Management Network Research: Formation and Development, Properties, and Performance

Although network analysis has gained much attention in emergency management studies, there are few systematic reviews of emergency management network studies in public administration. After reviewing 44 journals, this article identified and reviewed a total of 58 studies that conducted network analysis in the context of emergency management. Based on existing literature, this article summarizes the common and unique factors driving network formation and development, describes the structural characteristics of emergency management networks, and reports the performance measures that have been used to evaluate network performance. It concludes by addressing research gaps, presenting propositions and recommendations for future research, and highlighting implications for emergency management practice. The context of this review is emergency management, but the three network research streams focused upon—network formation and development, network properties, and network performance—are relevant to all management and policy domains. This review also underscores the need to further explore the dynamic process of network formation and outcomes of network relationships and structures.