Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of monocytes in thrombotic diseases: a review

Cardiovascular and cerebrovascular diseases are the number one killer threatening people's life and health, among which cardiovascular thrombotic events are the most common. As the cause of particularly serious cardiovascular events, thrombosis can trigger fatal crises such as acute coronary syndrome (myocardial infarction and unstable angina), cerebral infarction and so on. Circulating monocytes are an important part of innate immunity. Their main physiological functions are phagocytosis, removal of injured and senescent cells and their debris, and development into macrophages and dendritic cells. At the same time, they also participate in the pathophysiological processes of pro-coagulation and anticoagulation. According to recent studies, monocytes have been found to play a significant role in thrombosis and thrombotic diseases of the immune system. In this manuscript, we review the relationship between monocyte subsets and cardiovascular thrombotic events and analyze the role of monocytes in arterial thrombosis and their involvement in intravenous thrombolysis. Finally, we summarize the mechanism and therapeutic regimen of monocyte and thrombosis in hypertension, antiphospholipid syndrome, atherosclerosis, rheumatic heart disease, lower extremity deep venous thrombosis, and diabetic nephropathy.
Cardiovascular health and potential cardiovascular risk factors in young athletes

Introduction Cardiovascular disease remains the most common cause of death worldwide, and early manifestations are increasingly identified in childhood and adolescence. With physical inactivity being the most prevalent modifiable risk factor, the risk for cardiovascular disease is deemed low in people engaging in regular physical exercise. The aim of this study was to investigate early markers and drivers of cardiovascular disease in young athletes pursuing a career in competitive sports. Methods One hundred and five athletes (65 males, mean age 15.7 ± 3.7 years) were characterized by measurement of body impedance to estimate body fat, blood pressure (BP), carotid femoral pulse wave velocity (PWV) to evaluate arterial elasticity, ergometry to assess peak power output, echocardiography to calculate left ventricular mass, and blood tests. Results Systolic BP was elevated in 12.6% and thereby more than twice as high as expected for the normal population. Similarly, structural vascular and cardiac changes represented by elevated PWV and left ventricular mass were found in 9.5% and 10.3%. Higher PWV was independently associated with higher systolic BP (β = 0.0186, p < 0.0001), which in turn was closely correlated to hemoglobin levels (β = 0.1252, p = 0.0435). In this population, increased left ventricular mass was associated with lower resting heart rate (β = −0.5187, p = 0.0052), higher metabolic equivalent hours (β = 0.1303, p = 0.0002), sport disciplines with high dynamic component (β = 17.45, p = 0.0009), and also higher systolic BP (β = 0.4715, p = 0.0354). Conclusion Despite regular physical exercise and in the absence of obesity, we found an unexpected high rate of cardiovascular risk factors. The association of PWV, systolic BP, and hemoglobin suggested a possible link between training-induced raised hemoglobin levels and altered vascular properties. Our results point toward the need for thorough medical examinations in this seemingly healthy cohort of children and young adults. Long-term follow-up of individuals who started excessive physical exercise at a young age seems warranted to further explore the potential adverse effects on vascular health.
Early Draper-mediated glial refinement of neuropil architecture and synapse number in the Drosophila antennal lobe

Glial phagocytic activity refines connectivity, though molecular mechanisms regulating this exquisitely sensitive process are incompletely defined. We developed the Drosophila antennal lobe as a model for identifying molecular mechanisms underlying glial refinement of neural circuits in the absence of injury. Antennal lobe organization is stereotyped and characterized by individual glomeruli comprised of unique olfactory receptor neuronal (ORN) populations. The antennal lobe interacts extensively with two glial subtypes: ensheathing glia wrap individual glomeruli, while astrocytes ramify considerably within them. Phagocytic roles for glia in the uninjured antennal lobe are largely unknown. Thus, we tested whether Draper regulates ORN terminal arbor size, shape, or presynaptic content in two representative glomeruli: VC1 and VM7. We find that glial Draper limits the size of individual glomeruli and restrains their presynaptic content. Moreover, glial refinement is apparent in young adults, a period of rapid terminal arbor and synapse growth, indicating that synapse addition and elimination occur simultaneously. Draper has been shown to be expressed in ensheathing glia; unexpectedly, we find it expressed at high levels in late pupal antennal lobe astrocytes. Surprisingly, Draper plays differential roles in ensheathing glia and astrocytes in VC1 and VM7. In VC1, ensheathing glial Draper plays a more significant role in shaping glomerular size and presynaptic content; while in VM7, astrocytic Draper plays the larger role. Together, these data indicate that astrocytes and ensheathing glia employ Draper to refine circuitry in the antennal lobe before the terminal arbors reach their mature form and argue for local heterogeneity of neuron-glia interactions.
Coordination and divergence in community assembly processes across co-occurring microbial groups separated by cell size

Setting the pace of life and constraining the role of members in food webs, body size can affect the structure and dynamics of communities across multiple scales of biological organization (e.g., from the individual to the ecosystem). However, its effects on shaping microbial communities, as well as underlying assembly processes, remain poorly known. Here, we analyzed microbial diversity in the largest urban lake in China and disentangled the ecological processes governing microbial eukaryotes and prokaryotes using 16S and 18S amplicon sequencing. We found that pico/nano-eukaryotes (0.22−20 μm) and micro-eukaryotes (20−200 μm) showed significant differences in terms of both community composition and assembly processes even though they were characterized by similar phylotype diversity. We also found scale dependencies whereby micro-eukaryotes were strongly governed by environmental selection at the local scale and dispersal limitation at the regional scale. Interestingly, it was the micro-eukaryotes, rather than the pico/nano-eukaryotes, that shared similar distribution and community assembly patterns with the prokaryotes. This indicated that assembly processes of eukaryotes may be coupled or decoupled from prokaryotes’ assembly processes based on eukaryote cell size. While the results support the important influence of cell size, there may be other factors leading to different levels of assembly process coupling across size classes. Additional studies are needed to quantitatively parse the influence of cell size versus other factors as drivers of coordinated and divergent community assembly processes across microbial groups. Regardless of the governing mechanisms, our results show that there are clear patterns in how assembly processes are coupled across sub-communities defined by cell size. These size-structured patterns could be used to help predict shifts in microbial food webs in response to future disturbance.
A comprehensive review on motion trajectory reconstruction for EEG-based brain-computer interface

The advance in neuroscience and computer technology over the past decades have made brain-computer interface (BCI) a most promising area of neurorehabilitation and neurophysiology research. Limb motion decoding has gradually become a hot topic in the field of BCI. Decoding neural activity related to limb movement trajectory is considered to be of great help to the development of assistive and rehabilitation strategies for motor-impaired users. Although a variety of decoding methods have been proposed for limb trajectory reconstruction, there does not yet exist a review that covers the performance evaluation of these decoding methods. To alleviate this vacancy, in this paper, we evaluate EEG-based limb trajectory decoding methods regarding their advantages and disadvantages from a variety of perspectives. Specifically, we first introduce the differences in motor execution and motor imagery in limb trajectory reconstruction with different spaces (2D and 3D). Then, we discuss the limb motion trajectory reconstruction methods including experiment paradigm, EEG pre-processing, feature extraction and selection, decoding methods, and result evaluation. Finally, we expound on the open problem and future outlooks.
Comprehensive Review of Hypertensive Disorders Related to Pregnancy

The authors described hypertensive disorders of pregnancy, mainly preeclampsia and chronic hypertension in pregnancy, by discussing the pathophysiology, the central role of abnormal placentation, the release of antiangiogenic factors in the circulation and immunological factors, the clinical outcome in the mother and the fetus, and the diagnostic criteria and principles of management of both conditions. They also discussed possible screening methods and prevention of preeclampsia using low-dose aspirin and eclampsia prophylaxis. Abstract Hypertensive disorder of pregnancy is a common complication during pregnancy that affects approximately 10% of pregnancies and is responsible for nearly 14% of maternal deaths worldwide. It affects the mother and the fetus simultaneously, sometimes putting the health of the mother and the fetus at odds with each other. It may present with only hypertension and proteinuria or with life-threatening complications in the mother such as eclampsia; stroke; acute pulmonary edema; acute renal failure; disseminated intravascular coagulation; placental abruption; hemolysis, elevated liver enzymes, and low platelet syndrome; pregnancy loss; and fetal growth restriction and prematurity resulting from the frequent need of delivering preterm in the fetus. In this review, we aimed to describe hypertensive disorders of pregnancy, mainly preeclampsia and chronic hypertension in pregnancy, by discussing the pathophysiology, the central role of abnormal placentation, the release of antiangiogenic factors in the circulation and immunological factors, the clinical outcome in the mother and the fetus, and the diagnostic criteria and principles of management of both the conditions. We also discuss possible screening methods and prevention of preeclampsia using low-dose aspirin and eclampsia prophylaxis.
A Strict Patient Selection Protocol Could Be the Key to Success for Transanal Minimally Invasive Surgery (TAMIS)

This study investigated the feasibility of transanal minimally invasive surgery (TAMIS), as well as its excision quality, its oncologic outcomes, and its impact on anorectal function. Patients who underwent TAMIS at a single colorectal unit of a tertiary university hospital for benign rectal lesions or earlystage malignant rectal lesions, along with unsuitable patients for radical interventions, were included. TAMIS seemed to be a feasible technique with adequate oncologic outcomes and high excision quality, which preserved patients ’ quality of life. Abstract Objectives In recent years, the local excision of benign rectal lesions or early-stage rectal cancers using minimally invasive surgical techniques has replaced radical interventions that caused impairment in patients’ quality of life. The aim of the present study was to investigate the feasibility of transanal minimally invasive surgery (TAMIS), as well as its excision quality, its oncologic outcomes, and its impact on anorectal function. Methods Patients who underwent TAMIS at a single colorectal unit of a tertiary university hospital from 2015 until 2020 for benign rectal lesions or early-stage malignant rectal lesions, along with unsuitable patients for radical interventions, were included in the present study. Results Twenty-five patients underwent TAMIS for rectal lesions. Their median distance from the anal verge was 7 cm (range 4–12 cm) and their median size was 3.8 cm (range 2–6 cm). The median operative duration was 75 minutes (range 30–150 minutes) and the median hospitalization interval was 2 days (range 1–6 days). In addition, the negative resection rate was 100% and the recurrence rate was 4% during an average follow-up period of 30 months (range 3–36 months). Two patients (8%) presented short-term complications, and in 1 patient (4%) a hybrid technique was required. Seventeen patients (68%) reported moderate incontinence symptoms 6 weeks postoperatively that subsided in all patients 3 months postoperatively. Conclusions TAMIS seemed to be a feasible technique with adequate oncologic outcomes and high excision quality, which preserved patients’ quality of life. The impact of TAMIS on anorectal function after neoadjuvant chemoradiotherapy for rectal cancer should be further investigated, however.
Metrics for Monitoring Preoperative Optimization Programs for Total Joint Arthroplasty

Preoperative optimization programs are becoming more common for patients seeking total joint arthroplasty; yet, limited research has been conducted to monitor the long-term effects of these programs on patient outcomes. Our aim was to develop a set of metrics that programs can use to monitor the success of preoperative optimization programs. As part of a larger survey of orthopaedic nurses, we collected data regarding current monitoring techniques for preoperative optimization programs and the feasibility of collecting specific variables. Surgical factors such as length of stay and 30-day readmissions were most often used to monitor the success of preoperative optimization programs. Surgical factors were the most likely to be accessible using the electronic medical record. Surgical factors and patient characteristics are the most feasible components for programs to monitor in order to track the outcomes of patients participating in preoperative optimization programs.
RSA-Public Key Cryptosystems Based on Quadratic Equations in Finite Field

The importance of Public Key Cryptosystems (PKCs) in the cryptography field is well known. They represent a great revolution in this field. The PKCs depend mainly on mathematical problems, like factorization problem, and a trapdoor one-way function problem. Rivest, Shamir, and Adleman (RSA) PKC systems are based on factorization mathematical problems. There are many types of RSA cryptosystems. Rabin’s Cryptosystem is considered one example of this type, which is based on using the square order (quadratic equation) in encryption function. Many cryptosystems (since 1978) were implemented under such a mathematical approach. This chapter provides an illustration of the variants of RSA-Public Key Cryptosystems based on quadratic equations in Finite Field, describing their key generation, encryption, and decryption processes. In addition, the chapter illustrates a proposed general formula for the equation describing these different types and a proposed generalization for the Chinese Remainder Theorem.
A Parallel Corpus-Based Approach to the Crime Event Extraction for Low-Resource Languages

These days, a lot of crime-related events take place all over the world. Most of them are reported in news portals and social media. Crime-related event extraction from the published texts can allow monitoring, analysis, and comparison of police or criminal activities in different countries or regions. Existing approaches to event extraction mainly suggest processing texts in English, French, Chinese, and some other resource-rich and well-annotated languages. This paper presents a parallel corpus-based approach that follows a closed-domain event extraction methodology to event extraction from web news articles in low-resource languages. To identify the event, its arguments, and the arguments’ roles in the source-language part of the corpus we utilize an enhanced pattern-based method that involves the multilingual synonyms dictionary with knowledge about crime-related concepts and logic-linguistic equations. The event extraction from the target-language part of the corpus uses a cross-lingual crime-related event extraction transfer technique that is based on supplementary knowledge about the semantic similarity patterns of the considered pair of languages. The presented approach does not require a preliminarily annotated corpus for training making it more attractive to low-resource languages and allows extracting TRANSFER, CRIME, and POLICE types of events and their seven subtypes from various topics of news articles simultaneously. Implementation of our approach for the Russian-Kazakh parallel corpus of news portals articles allowed obtaining the F1-measure of crime-related event extraction of over 82% for the source language and 63% for the target language.
Fabrication of High-Temperature Polymer- Derived Ceramic Thin-Film Heat Flux Sensor by 3-D Printing and Laser Pyrolysis

Heat flux density is an important parameter for evaluating the high-temperature performance of turbine blades. Accurate heat flux density data play a significant role in the design and manufacture of turbine blades and their heat-dissipation performance. Current studies have shown that thin-film heat flux sensors (TFHFSs) are suitable for signal monitoring of complex turbine blade surfaces. However, TFHFSs have a multilayer structure, which is difficult to achieve using traditional physical vapor deposition (PVD). In this article, we propose an approach to fabricate high-temperature polymer-derived ceramic (PDC) TFHFSs using 3-D printing and laser pyrolysis. Through direct ink writing (DIW), sensitive, antioxidant, and thermal resistance layers were written directly on an alumina substrate. The sensitive layer was rendered electrically conductive owing to laser-induced graphitization. Thus, the structure of multilayer TFHFS can be quickly achieved using the proposed method. The results showed that the sensor can operate at 800 °C. Its sensitivity was 1.349 mV/(kW/ $\text{m}^{{2}}{)}$ . Thus, it is feasible to prepare TFHFSs by 3-D printing and laser pyrolysis, which provides a new in situ integrated manufacturing method for fabricating heat flux sensors suitable for working in harsh environments such as aviation.
LiDAR Inertial Odometry Based on Indexed Point and Delayed Removal Strategy in Highly Dynamic Environments

Simultaneous localization and mapping (SLAM) is considered a challenge in environments with many moving objects. This paper proposes a novel LiDAR inertial odometry framework, LiDAR inertial odometry-based on indexed point and delayed removal strategy (ID-LIO) for dynamic scenes, which builds on LiDAR inertial odometry via smoothing and mapping (LIO-SAM). To detect the point clouds on the moving objects, a dynamic point detection method is integrated, which is based on pseudo occupancy along a spatial dimension. Then, we present a dynamic point propagation and removal algorithm based on indexed points to remove more dynamic points on the local map along the temporal dimension and update the status of the point features in keyframes. In the LiDAR odometry module, a delay removal strategy is proposed for historical keyframes, and the sliding window-based optimization includes the LiDAR measurement with dynamic weights to reduce error from dynamic points in keyframes. We perform the experiments both on the public low-dynamic and high-dynamic datasets. The results show that the proposed method greatly increases localization accuracy in high-dynamic environments. Additionally, the absolute trajectory error (ATE) and average RMSE root mean square error (RMSE) of our ID-LIO can be improved by 67% and 85% in the UrbanLoco-CAMarketStreet dataset and UrbanNav-HK-Medium-Urban-1 dataset, respectively, when compared with LIO-SAM.
A novel autophagy-related subtypes to distinguish immune phenotypes and predict immunotherapy response in head and neck squamous cell carcinoma

Both the absence of autophagy and excessive autophagy is double-edged sword in tumorigenesis. Due to the specificity of autophagy, its role in head and neck squamous cell carcinoma (HNSCC) is still unclear. In this study, we established five autophagy-related patterns in 1165 HNSCC patients with distinct cellular and molecular characteristics. Additionally, we developed a new scoring system (ATPscore) based on the differentially expressed genes (DEGs) among these five patterns, to represent the individual autophagy regulation pattern. ATPscore was shown to be significantly correlated with tumor immune microenvironment (TIME) infiltration, immune phenotypes, molecular subtypes, and genetic variations. We further found that ATPscore was both an independent prognostic factor and a potent predictor of clinical response to immune-checkpoint inhibitors (ICIs)-based immunotherapy. We further verified the value of key gene SRPX in ATPscore in HNSCC cell lines with the in-depth research of ATPscore and found that it is closely related to immune subtypes, molecular subtypes, and immune activation-related markers. Our research could help us to understand the underlying mechanisms of tumor immunity and provide a solid foundation for the combination of autophagy-targeted therapies with immunotherapies for clinical application in HNSCC.
Uterine Artery Embolization in a Patient With Large Uterine Fibroids

A woman in her 20s with no past medical history presented to the emergency department with a 4-day history of abdominal pain. Imaging revealed several large uterine fibroids that compressed various intra-abdominal structures. Options of observation, medical management, surgical management with abdominal myomectomy, and uterine artery embolization (UAE) were discussed. The patient was counseled about the associated risks of UAE and myomectomy. Since both procedures have a risk of infertility, the patient elected to proceed with uterine artery embolization due to the less invasive nature of the procedure. She was discharged after one day in the hospital following the procedure and readmitted three days later for suspected endometritis. The patient was treated with antibiotics for five days and discharged home. Eleven months post-procedure, the patient became pregnant. The patient had achieved a full-term delivery at 39 weeks and two days via a cesarean section secondary to a breech presentation.
A publicação voluntária de informações socioambientais como forma de legitimação das organizações do terceiro setor e acesso ao mercado de doações

O objetivo desta pesquisa, realizada através de dados secundários, é responder qual o padrão mais propício para a publicação de relatórios socioambientais no Terceiro Setor, considerando os seus benefícios frente a legitimação das organizações e a captação de recursos junto ao mercado de doações. A situação atual marcada pelo empobrecimento do mundo, o anacronismo dos governos e suas políticas públicas e a forte tendência de desglobalização fizeram com que os recursos destinados ao Terceiro Setor fossem contingenciados causando uma enorme dependência do mercado de doações. Esta pesquisa é composta por uma sintética introdução, a fundamentação teórica que sustenta o trabalho realizado, as análises realizadas e, por fim, as conclusões, limitações e sugestões para novos estudos. Foi possível concluir que a divulgação de informações corporativas, de forma voluntária, além de apoiar a construção da legitimidade das organizações, é imprescindível como prática de governança e tende a ser um elemento catalizador para o sucesso da captação de recursos e o acesso ao mercado de doações do Terceiro Setor. Concluiu-se também que o Terceiro Setor ao realizar suas demonstrações socioambientais deve considerar o padrão preconizado pelo Global Reporting Initiative, sendo integradas com o Relato Integrado.