Miracle-dz/UniFAR-FTUs huggingface dataset:
Minimize COVID-19 Infection for Migrant Farmworkers

dear Editor, we read the article entitled “Innovative Cohort Process to Minimize COVID-19 Infection for Migrant Farmworkers During Travel to Iowa” ( Johnson et al., 2022). They mentioned that “With support in place from the top down, employers, workers, and health care providers will be able to prioritize the management of infectious diseases and the needs of essential workers (p. 17). ” The migrant worker community has been described as a “hotspot” for the COVID-19 epidemic in various places, including Southeast Asia (Chookajorn et al., 2021). We agree that it is necessary to minimize COVID-19 infection for migrant workers. Migrant laborers usually have a culture that is different from the local residents. They frequently have a low socioeconomic status, making it harder for them to receive local health care. Migrant workers are more likely to contract COVID-19 when there is a shortage of effective health care (Suphanchaimat, Tuangratananon, et al., 2021). COVID-19 outbreaks have occurred in migrant worker communities in several nations with migrant worker communities (Suphanchaimat, Nittayasoot, et al., 2021; Suphanchaimat, Tuangratananon, et al., 2021). Furthermore, many migrant workers entered countries illegally to work, and there is no official record of their presence for public scrutiny. Concerning the aforementioned issues, detailed planning for COVID-19 management among migrants is difficult and requires competent management. In our view, vaccination is the most efficient COVID-19 prevention method currently available. The immunization of migrant workers is difficult because significant barriers must be overcome for the vaccination to be successful. For example, many migrant workers are undocumented which means they are not covered by vaccination programs. Furthermore, migrant workers may face linguistic and cultural obstacles, making it harder to give information about the benefits of immunization. In many settings, vaccines are primarily given to the local native population, while the migrant/minority population is sometimes overlooked (Suphanchaimat, Tuangratananon, et al., 2021; Teerawattananon et al., 2021). Yet, according to a recent study from Indochina, vaccinations for migrant laborers are extremely cost-effective (Suphanchaimat, Nittayasoot, et al., 2021; Suphanchaimat, Tuangratananon, et al., 2021). It is suggested that migrant workers should not only get priority for vaccination, but also receive vaccination at no cost as a strategy to increase coverage (Suphanchaimat, Tuangratananon, et al., 2021).
The potential role of extracellular vesicles in bioactive compound-based therapy: A review of recent developments

Abstract Recent studies have explored the field of extracellular vesicles (EVs), driving an increasing interest in their application to human health. EVs have unique physicochemical traits to participate in intercellular communication, thus fostering the idea of using EVs to yield synergistic, preventive, and therapeutic effects. Many reports have shown that EVs contain natural bioactive compounds, such as lipids, proteins, RNA, and other active components that regulate biological processes, thereby contributing to human health. Therefore, in this review, we comprehensively elucidate various facets of the relationship between EVs and bioactive compounds that modulate EVs contents, including RNAs and proteins, discussing different forms of biological regulation. The use of EVs for cargo-loading bioactive compounds to exert biological functions and methods to load bioactive compounds into EVs are also discussed. This review highlighted the effect of EV-delivered bioactive compounds on several therapeutic mechanisms and applications, providing new insight into nutrition and pharmacology.
High-throughput UAV-based phenotyping provides insights into the dynamic process and genetic basis of rapeseed waterlogging response in the field.

Waterlogging severely affects the growth, development, and yield of crops. Accurate high-throughput phenotyping is important for exploring the dynamic crop waterlogging response process in the field and the genetic basis of waterlogging tolerance. In this study, a multi-model remote sensing phenotyping platform based on an unmanned aerial vehicle (UAV) was used to assess the genetic response of rapeseed (Brassica napus) to waterlogging by measuring morphological traits and spectral indices in two years. The dynamic responses of the morphological and spectral traits indicated that the rapeseed waterlogging response was severe before the middle stage within 18 days after recovery, but it partly decreased subsequently. Genome-wide association studies identified 289 and 333 loci associated with waterlogging tolerance in two years. Next, 25 loci with at least nine associations with waterlogging-related traits were defined as highly reliable loci, and 13 loci were simultaneously identified by waterlogging tolerance coefficients of morphological traits, spectral indices, and common factors. Forty candidate genes were predicted in the regions of 13 overlapping loci. Our study provides insights into the understanding of dynamic process and genetic basis of rapeseed waterlogging response in the field by a high-throughput UAV phenotyping platform. The highly reliable loci identified in this study are valuable for breeding waterlogging-tolerant rapeseed cultivars.
The quantitative genetics of fitness in a wild seabird

Additive genetic variance in fitness is a prerequisite for adaptive evolution, as a trait must be genetically correlated with fitness to evolve. Despite its relevance, additive genetic variance in fitness has not often been estimated in nature. Here, we investigate additive genetic variance in lifetime and annual fitness components in common terns (Sterna hirundo). Using 28 years of data comprising approximately 6000 pedigreed individuals, we find that additive genetic variances in the zero‐inflated and Poisson components of lifetime fitness were effectively zero but estimated with high uncertainty. Similarly, additive genetic variances in adult annual reproductive success and survival did not differ from zero but were again associated with high uncertainty. Simulations suggested that we would be able to detect additive genetic variances as low as 0.05 for the zero‐inflated component of fitness but not for the Poisson component, for which adequate statistical power would require approximately two more decades (four tern generations) of data collection. As such, our study suggests heritable variance in common tern fitness to be rather low if not zero, shows how studying the quantitative genetics of fitness in natural populations remains challenging, and highlights the importance of maintaining long‐term individual‐based studies of natural populations.
The 100 Most-Cited Papers on Giant Cell Arteritis: A Bibliometric Analysis.

BACKGROUND Giant cell arteritis (GCA) carries significant risk of vascular and visual morbidity. Given its clinical importance, the 100 most frequently cited articles on GCA were systematically identified and bibliometrically analyzed. METHODS All databases belonging to the Web of Science platform were searched for research articles with no restriction on publication date. The distribution of papers among journals, countries of origin, and publication type were evaluated. The correlations between year of publication with total number of citations and annual citation rate were also assessed. RESULTS The top 100 articles on GCA were published between 1946 and 2018 and were cited a median (range) of 229 (153-1,751) times. The papers were published in 30 journals, including nine rheumatology journals (n=45), seven general medical journals (n=21), three ophthalmology journals (n=8), and eleven journals from other fields of research (n=26). Based on corresponding author affiliation, the articles originated from 13 countries, led by the US (n=55), Spain (n=12), and the UK (n=11). Clinical studies (n=73) and non-systematic reviews (n=11) were the most common publication types. The median (range) number of authors per article was 5 (1-44), and 73 individuals had more than one authorship. Year of publication was significantly correlated with annual citation rate (p<0.001) but not with total number of citations (p=0.487). CONCLUSION This bibliometric analysis provides insight into the history and evolution of GCA research, highlighting some of the most influential contributions to the field. The latest landmark papers may not have been identified due to temporal constraints on citation accumulation.
Development of cost efficient ADAS tool platform for automotive industry

This article focuses on the outcomes and key challenges of DESERVE project. The project aims at developing a new platform for Advanced Driver Assistance Systems (ADAS) functions that is based on common software tools to increase interoperability between the software components and consequently reducing their development costs. The design of ADAS functions able to support and cooperate with drivers is an important issue in the Intelligent Transportation Systems (ITS) research. The ADAS design aims at enhancing the driver’s perception of hazards and critical situations, in order to reduce accidents and injuries and to improve road safety. In addition to the development of the automotive components also driver was taken into account by introducing new driver model and driver monitoring technology, in order to allow smooth transition from driver assistance to semiautomatic driving and finally to full automation.
Sleep from acute to chronic traumatic brain injury and cognitive outcomes.

STUDY OBJECTIVES Traumatic brain injuries (TBI) cause persistent cerebral damage and cognitive deficits. Because sleep may be a critical factor to brain recovery, we characterized the sleep of patients with traumatic brain injury from early hospitalization to years post-injury, and explored the hypothesis that better sleep during hospitalization predicts more favorable long-term cognitive outcomes. METHODS We tested patients with moderate to severe TBI in the hospitalized (n=11) and chronic (n=43) stages using full-night polysomnography, with 82% of the hospitalized group being retested years post-injury. Hospitalized patients with severe orthopedic and/or spinal cord injury (n=14) and healthy participants (n=36) were tested as controls for the hospitalized and chronic TBI groups respectively. Groups had similar age and sex and were compared for sleep characteristics, including slow waves and spindles. For patients with TBI, associations between sleep during hospitalization and long-term memory and executive function were assessed. RESULTS Hospitalized patients with TBI or orthopedic injuries had lower sleep efficiency, higher wake after sleep onset, and lower spindle density than the chronic TBI and healthy control groups, but only hospitalized patients with brain injury had increased proportion of slow-wave sleep. During hospitalization for TBI, less fragmented sleep, more slow-wave sleep, and higher spindle density were associated to more favorable cognitive outcomes years post-injury, while injury severity markers were not associated with these outcomes. CONCLUSION These findings highlight the importance of sleep following TBI, as it could be a strong predictor of neurological recovery, either as a promoter or an early marker of cognitive outcomes.
Identification of a novel DFNA5 mutation, IVS7-2 a > G, in a Chinese family with non-syndromic sensorineural hearing loss

Abstract Background To date, seven DFNA5 mutations have been reported in families with autosomal dominant non-syndromic hearing loss worldwide. All the mutations cause exon 8 skipping at the mRNA level, that led to the protein truncated and the protein could exert a gain of ototoxic function. Objective In this study, we found an autosomal-dominant non-syndromic hearing loss Chinese pedigree which spanned four generations and comprised 43 members. We want to identify the causative gene and mutation. Methods Application of microsatellite markers on DFNA 23 loci preliminary screening of 25 genes, data were analyzed by linkage analysis. Results We mapped the locus to the region between D7S629 and D7S516 (two-point lod-score of 5.39) with the application of 8 microsatellite markers. By direct sequencing of candidate genes in mapping region, we identified a novel missense mutation ivs7-2 A > G in DFNA5 gene, which was faithfully cosegregated with hearing loss in the family. Conclusion and significance The missense mutation in intron 7 of DFNA5 causes skipping of exon 8, resulting in premature termination of the open reading frame. This type of mutation has repeatedly confirmed that it provides more evidence for the previous view and provides a more solid foundation for future research.
Phylogenomic Analysis of Metagenome-Assembled Genomes Deciphered Novel Acetogenic Nitrogen-Fixing Bathyarchaeota from Hot Spring Sediments

We describe the Bathyarchaeota bins that are likely to be acetogens with a wide range of metabolic potential. These bins did not exhibit methanogenic machinery, suggesting methane production may not occur by all subgroup lineages of Bathyarchaeota. Phylogenetic analysis support that both ILS200 and ILS300 belonged to the Bathyarchaeota. The discovery of new bathyarchaeotal MAGs provides additional knowledge for understanding global carbon and nitrogen metabolism under extreme conditions. ABSTRACT This study describes the phylogenomic analysis and metabolic insights of metagenome-assembled genomes (MAGs) retrieved from hot spring sediment samples. The metagenome-assembled sequences recovered three near-complete genomes belonging to the archaeal phylum. Analysis of genome-wide core genes and 16S rRNA-based phylogeny placed the ILS200 and ILS300 genomes within the uncultivated and largely understudied bathyarchaeal phylum, whereas ILS100 represented the phylum Thaumarchaeota. The average nucleotide identity (ANI) of the bin ILS100 was 76% with Nitrososphaeria_archaeon_isolate_SpSt-1069. However, the bins ILS200 and ILS300 showed ANI values of 75% and 70% with Candidatus_Bathyarchaeota_archaeon_isolate_DRTY-6_2_bin_115 and Candidatus_Bathyarchaeota_archaeon_BA1_ba1_01, respectively. The genomic potential of Bathyarchaeota bins ILS200 and ILS300 showed genes necessary for the Wood-Ljungdahl pathway, and the gene encoding the methyl coenzyme M reductase (mcr) complex essential for methanogenesis was absent. The metabolic potential of the assembled genomes included genes involved in nitrogen assimilation, including nitrogenase and the genes necessary for the urea cycle. The presence of these genes suggested the metabolic potential of Bathyarchaeota to fix nitrogen under extreme environments. In addition, the ILS200 and ILS300 genomes carried genes involved in the tricarboxylic acid (TCA) cycle, glycolysis, and degradation of organic carbons. Finally, we conclude that the reconstructed Bathyarchaeota bins are autotrophic acetogens and organo-heterotrophs. IMPORTANCE We describe the Bathyarchaeota bins that are likely to be acetogens with a wide range of metabolic potential. These bins did not exhibit methanogenic machinery, suggesting methane production may not occur by all subgroup lineages of Bathyarchaeota. Phylogenetic analysis support that both ILS200 and ILS300 belonged to the Bathyarchaeota. The discovery of new bathyarchaeotal MAGs provides additional knowledge for understanding global carbon and nitrogen metabolism under extreme conditions.
Acute Fatigue Responses to Occupational Training in Military Personnel: A Systematic Review and Meta-Analysis

ABSTRACT Introduction Military personnel are required to undertake rigorous physical training to meet the unique demands of combat, often leading to high levels of physiological stress. Inappropriate recovery periods with these high levels of physical stress may result in sub-optimal training and increased risk of injury in military personnel. However, no reviews have attempted to examine the magnitude of training-induced stress following military training activities. The aim of this systematic review was to assess the magnitude of physiological stress (physical, hormonal, and immunological) following task-specific training activities in military personnel. Methods An extensive literature search was conducted within CINAHL, PubMed, Scopus, SportDiscus, and Web of Science databases with 7,220 records extracted and a total of 14 studies eligible for inclusion and evaluation. Study appraisal was conducted using the Kmet scale. Meta-analysis was conducted via forest plots, with standard mean difference (SMD, effect size) and inter-trial heterogeneity (I2) calculated between before (preactivity) and after (12–96 hours postactivity) military-specific activities for biomarkers of physiological stress (muscle damage, inflammation, and hormonal) and physical performance (muscular strength and power). Results Military training activities resulted in significant levels of muscle damage (SMD = −1.28; P = .003) and significant impairments in strength and power (SMD = 0.91; P = .008) and testosterone levels (SMD = 1.48; P = .05) up to 96 hours postactivity. There were no significant differences in inflammation (SMD = −0.70; P = .11), cortisol (SMD = −0.18; P = .81), or insulin-like growth factor 1 (SMD = 0.65; P = .07) when compared to preactivity measures. Conclusions These findings indicate that assessments of muscle damage, anabolic hormones like testosterone, strength, and power are effective for determining the level of acute stress following military-specific activities. With regular monitoring of these measures, appropriate recovery periods may be implemented to optimize training adaptations and occupational performance, with minimal adverse training responses in military personnel.
Religiosity, Sexual Satisfaction, and Relationship Satisfaction: The Moderating Role of Sexual Mindfulness and Sexual Sanctification

Abstract There are a variety of conditions under which religiosity may be positively or negatively associated with sexual and relationship satisfaction. To better understand these conditions, we conducted two studies using two separate samples: one with individuals (1,695 individuals), and one with couples (481 dyads), to test how sexual sanctification and sexual mindfulness moderate these associations. Across studies sexual mindfulness was positively associated with sexual and relationship satisfaction for the individual and partner, but there was no evidence for moderation; sexual sanctification was consistently associated with higher sexual and relationship satisfaction, and in some cases moderated the association between religiosity and both sexual and relationship satisfaction for women and men. In Study 1, religiosity was associated with lower sexual and relationship satisfaction for both men and women when sexual sanctification was low, but not with either type of satisfaction when sexual sanctification was high. In Study 2, religiosity was positively associated with sexual satisfaction for men but only when sexual sanctification was high. The combined evidence indicates that sexual sanctification may be one factor that distinguishes whether religion helps or hinders sexual and relationship satisfaction.
Combination of Houttuynia cordata polysaccharide and Lactiplantibacillus plantarum P101 alleviates acute liver injury by regulating gut microbiota in mice.

BACKROUND Polysaccharides and probiotics can play an excellent role in the treatment of liver disease by regulating gut microbiota. Recently, the combined therapeutic effect of probiotics and polysaccharides has attracted the attention of researchers. Here, Houttuynia cordata polysaccharide (HCP) combined with Lactiplantibacillus plantarum P101 was used to prevent CCl4 -induced acute liver injury (ALI) in mice, and its effect on gut microbiota regulation was explored. RESULTS Results showed that in mice, HCP combined with L. plantarum P101 significantly alleviated oxidative stress and inflammatory injury in the liver by activating Nrf2 signal and inhibiting NF-κB signal. The analysis of gut microbiota revealed that the combination of HCP and L. plantarum P101 increased the abundances of beneficial bacteria such as Alloprevotella, Roseburia and Akkermansia, but decreased those of the pro-inflammatory bacteria Alistipes, Enterorhabdus, Anaerotruncus and Escherichia-Shigella. In addition, correlation analysis indicated that the expression of Nrf2 and TLR4/NF-κB was connected with the changes in gut microbiota composition. HCP combined with L. plantarum P101 can regulate the gut microbiota and then mediate the gut-liver axis to activate the antioxidant pathway and inhibit inflammatory responses, thereby alleviating CCl4 -induced ALI. CONCLUSION Our study provided a new perspective for polysaccharides combined with probiotics in the treatment of liver disease. This article is protected by copyright. All rights reserved.
Art skill-based rehabilitation training for upper limb sensorimotor recovery post-stroke: A feasibility study

Objective The objective of this study was to assess the feasibility of delivering Art skill-based Rehabilitation Training (ART), a novel upper limb motor training program, to patients with stroke as an adjunct to standard care in an inpatient setting. Design Feasibility study. Setting Inpatient stroke rehabilitation unit at a university hospital. Participants Thirty-eight patients admitted to a stroke rehabilitation unit with upper limb motor impairment were enrolled in the ART program facilitated by trained non-healthcare professionals between December 2017 and June 2021. Intervention The ART program included nine, one-hour sessions of supervised tracing and freehand drawing tasks completed with both hands. This program was intended to be delivered at a frequency of three times per week over a duration of 3 weeks or for the length of inpatient stay. Main outcome measures Feasibility outcomes included ART program adherence, acceptability, and safety. Results Thirty-two (84%) participants with subacute stroke completed the ART program and 30 (79%) were included in the study analysis. Participants completed 93–100% of the ART tasks in a median [IQR] of 8 [6–10] ART sessions over a median [IQR] duration of 15 [7–19] days. ART program facilitators effectively provided upper limb assistance to patients with more severe upper limb impairments. Adherence and acceptability were high and no study-related adverse events occurred. Conclusion The ART program was feasible to deliver and highly acceptable to patients with stroke. Further research is warranted to explore the impact of ART on upper limb sensorimotor function and use.
An Approach on Determination on Coal Quality using Digital Image Processing

Worldwide coal in the 21st century will be influenced by concerns about the effects of coal combustion on the local, regional and global environment and on human health. Reliable coal quality data can help decision maker to better assess the risks and limit the possible environmental degradation and impact on health. Although millions of coal analysis have been performed worldwide, existing national quality databases are generally of limited use because much of the data are not readily accessible; geographic coverage are not comprehensive; analytical data may not be accurate; samples may not be representative, or current. This paper attempts to gives a fast, accurate, user-friendly and computerized method for analysis of coal quality using techniques of digital image processing for its better utilization.