Miracle-dz/UniFAR-FTUs huggingface dataset:
Common Genomic Aberrations in Mouse and Human Breast Cancers with Concurrent P53 Deficiency and Activated PTEN-PI3K-AKT Pathway

Simultaneous P53 loss and activation of the PTEN-restricted PI3K-AKT pathway frequently occur in aggressive breast cancers. P53 loss causes genome instability, while PTEN loss and/or activating mutations of PIK3CA and AKT promote cancer cell proliferation that also increases incidences of genomic aberrations. However, the genomic alterations associated with P53 loss and activated PTEN-PI3K-AKT signaling in breast cancer have not been defined. Spatiotemporally controlled breast cancer models with inactivation of both P53 and Pten in adult mice have not been established for studying genomic alterations. Herein, we deleted both floxed Pten and Tp53 genes in the mammary gland epithelial cells in adult mice using a RCAS virus-mediated Cre-expressing system. These mice developed small tumors in 21 weeks, and poorly differentiated larger tumors in 26 weeks. In these tumors, we identified 360 genes mutated by nonsynonymous point mutations and small insertions and deletions (NSPMs/InDels), 435 genes altered by copy number amplifications (CNAs), and 450 genes inactivated by copy number deletions (CNDs). Importantly, 22.2%, 75.9% and 27.3% of these genes were also altered in human breast tumors with P53 and PTEN losses or P53 loss and activated PI3K-AKT signaling by NSPMs/InDels, CNAs and CNDs, respectively. Therefore, inactivation of P53 and Pten in adult mice causes rapid-growing breast tumors, and these tumors recapitulate a significant number of genetic aberrations in human breast tumors with inactivated P53 and activated PTEN-PI3K-AKT signaling. Further characterization of these commonly altered genes in breast cancer should help to identify novel cancer-driving genes and molecular targets for developing therapeutics.
Innovations in microwave filters and multiplexing networks for communications satellite systems

The evolution of microwave filters and multiplexers for space application is described. The many advances are described within the context of the design of the overall communication subsystem. Emphasis is placed on the multipaction and passive intermodulation (PIM) considerations in designing high-power multiplexers. The impact of microwave filter technology in the channel characterization of satellite systems is described. The future directions of research and development are briefly discussed. >
A Hybrid Deep Learning Model for Automatic Modulation Classification

Automatic modulation classification (AMC) is one of the major challenges for cognitive radio (CR), which can enhance the spectrum utilization efficiency. In this study, a hybrid signal and image-based deep learning model is designed for AMC in CR. A convolutional neural network (CNN) is applied in both the deep learning models. The signal-based CNN (SBCNN) is designed with the optimal filter size for the prediction accuracy, which is used as a pre-training deep learning network to extract features with size $24\times 1$ . The features extracted by SBCNN are converted into heat map images, which showed RGB images in the scale range of −30 to +30. Finally, the images are utilized for training and testing the image-based CNN (IBCNN). The dataset used for the experiment is DeepSig: RADIOML2018.01A, which is the latest version. For the IBCNN, the prediction accuracy is 1.96%, 7.99%, and 4.63% higher at signal-to-noise ratio (SNR) 10 dB, and 3.26%, 6.4%, and 4.13% higher at SNR 0 dB as compared to conventional models: ECNN, SCGNet, and LCNN, respectively.
Cooperative control of regenerative braking and hydraulic braking of an electrified passenger car

With the aims of regeneration efficiency and brake comfort, three different control strategies, namely the maximum-regeneration-efficiency strategy, the good-pedal-feel strategy and the coordination strategy for regenerative braking of an electrified passenger car are researched in this paper. The models of the main components related to the regenerative brake and the frictional blending brake of the electric passenger car are built in MATLAB/Simulink. The control effects and regeneration efficiencies of the control strategies in a typical deceleration process are simulated and analysed. Road tests under normal deceleration braking and an ECE driving cycle are carried out. The simulation and road test results show that the maximum-regeneration-efficiency strategy, which causes issues on brake comfort and safety, could hardly be utilized in the regenerative braking system adopted. The good-pedal-feel strategy and coordination strategy are advantageous over the first strategy with respect to the brake comfort and regeneration efficiency. The fuel economy enhanced by the regenerative braking system developed is more than 25% under the ECE driving cycle.
The Relevance of Cluster Initiatives in Rural Areas : Regional Policy in Sweden

The relatively weak performance of sparsely populated areas has been given substantial attention in many regional, national and European Union initiatives. Many rural areas are struggling with development problems such as depopulation, advanced ageing, industrial restructuring and high levels of structural unemployment. In Sweden these issues are mainly associated with the difficulties in the non-metropolitan sparsely populated areas in the northern and southeastern parts. Here, the issue of implementing general cluster policies in sparsely populated regions in order to enhance their economic development is in focus. This research includes an overview of existing Swedish regional growth and development programmes that exemplify the current regional policies. It is found that the concepts of clusters and innovation systems have become important for policy on national and regional levels of government, but the understanding of the concepts is poor. In spite of regional variations in preconditions for cluster development, there are no clear regional modifications in the interpretation of clusters as described in the documents. One conclusion is that regional and local strategies to develop businesses in sparsely populated areas would benefit from using examples from non-metropolitan regions as a point of departure rather than using experiences drawn from high-tech industries located in metropolitan areas usually referenced in the international literature. The routine use of cluster and innovation systems in policy on the regional level underlines the need for more empirically based research on the preconditions for cluster development in sparsely populated areas.
A CMOS Temperature Sensor with a Maximum Accuracy of 1.6 °C after One-Point Calibration

This paper presents a time-domain CMOS oscillator-based temperature sensor with one-point calibration for test cost reduction. Compared with the former CMOS sensors with linear delay lines, the proposed work composed of a temperature-to-pulse generator with adjustable time gain and a time-to-digital converter (TDC) can achieve lower circuit complexity and smaller area. A temperature-dependent oscillator for temperature sensing was used to generate the period width proportional to absolute temperature (PTAT). With the help of calibration circuit, an adjustable-gain time amplifier was adopted to dynamically adjust the amplified width that was converted by the TDC into the corresponding digital code. After calibration, the fluctuation of the sensor output with process variation can be greatly reduced. The maximum inaccuracy after one-point calibration for six package chips was 1.6 °C within a 0 80 °C temperature range. The proposed sensor fabricated in a 0.35-μm CMOS process occupied a chip area of merely 0.07 mm2, achieved a fine resolution of 0.047 °C/LSB, and consumed a low power of 25 μW@10 samples/s.
BROADBAND TRIANGULAR MICROSTRIP ANTENNA WITH U-SHAPED SLOT

The broadband design of a triangular microstrip antenna with a U-shaped slot is demonstrated. With a foam substrate of thickness /spl sim/0.08 /spl lambda//sub 0/, a slotted triangular microstrip antenna with an operating bandwidth of /spl sim/18% is obtained, which is /spl sim/1.8 times that of a corresponding simple triangular patch antenna. Details of the antenna design and experimental results are presented.
PREDICTORS OF POOR PROGNOSIS IN PREGNANT WOMEN WITH COVID-19: A PROSPECTIVE COHORT STUDY IN THE MATERNITY MOTHER AND CHILD UNIVERSITY HOSPITAL OF CASABLANCA MOROCCO

Objective: We aim to study the clinicalcharacteristics, the evolution of COVID-19 on pregnant women and survival factors. Study design: Its a prospective cohortstudy in a large tertiary maternity unit within the Mother and Child University Hospital Ibn Rochd of Casablanca with an average annual birth of over 6950 births. We prospectively collected and analyzed data for a cohort of 40 pregnant patients tested positive for COVID-19 between January 2020 and December 2020 inclusive to assess the effect of COVID-19 on pregnancy. Results: Forty pregnant patients testedpositive for COVID-19, 36 patients gave birth and 4 patients died pregnant. The severity of the symptoms ranged from mild in 20/40 (50%) of the patients, moderate in 7/40 (17,5%), and severe in 13/40 (32,5%). Thirteen of our patients were admitted to invasive care units, six were in their third trimester, and seven in their second trimester nine were intubated and ventilated prior to delivery and three of them required Extracorporeal membrane oxygenation. Among these patients intubated only two survived. Most common comorbidities were gestational diabetes 4/40 (10 %), asthma 4/40 (10 %), preeclampsia 7/40 (17,5%). Of the 40 pregnant patients 31 (77,5%) were in their third trimester, 8 (20%) women in their second trimester, and one in her first trimester. Of the 36 patients who delivered, 12/36 (33,3 %) were preterm delivered by elective C-sections. The death rate was 17,5% (7/40). Conclusion: COVID-19 is associated with high prevalence of preterm birth, caesarean section, and a high mortality rate.
Simple Performance Test for Fatigue Cracking and Validation with WesTrack Mixtures

Viscoelastic characterization of asphalt concrete in indirect tensile (IDT) testing and development of a simple performance test for fatigue cracking are described. A 50-mm gauge length was adopted to measure the horizontal and vertical deformations with surface-mounted linear variable differential transducers on an IDT specimen with a 100- or 150-mm diameter and 38-mm thickness. The effect of a concentrated load under loading strips on vertical displacement within the 50-mm gauge length was evaluated by the digital image correlation method, a noncontact, full-field displacement and strain measurement technique. The theory of viscoelasticity was used to develop analytical solutions for creep compliance and center strain from displacements measured on the specimen surface. These solutions were verified by three-dimensional finite element viscoelastic analysis. IDT creep and strength tests were performed on fine and coarse mixtures from WesTrack with various asphalt contents and air void contents, and various parameters determined from the analysis of these data were compared with the known fatigue performance of these mixtures from the WesTrack testing facility. The fracture energy obtained from viscoelastic analysis of the IDT strength test at 20°C correlated highly with the field performance of these mixtures at WesTrack.
Simultaneous optimization of sailplane design and its flight trajectory

An aircraft design and its flight trajectory problem should be formulated simultaneously when an exact flight mission is determined or an extremely high-performance level is required. This article presents a block diagonal sequential quadratic programming approach by introducing interface variables between the two problems to efficiently solve simultaneous optimization problems. As numerical examples, the design of a sailplane for a flight distance competition is studied. The need of simultaneous optimization will be demonstrated by comparing a conventional design process; i.e., a lift-drag ratio maximization approach.
Recent developments in office design

Early in this century, extensive research was carried out regarding the worker in the industrial setting with the physical environment as the focus. In the 1930s, the focus became the social environment. Several developments have recently brought the physical environment into prominence and, in particular, the office as a work setting. The US economy has shifted from production to the provision of information and services, with 80 per cent of the workforce predicted to be in the office work setting by the year 2000, compared with 53 per cent today. The work environment is also changing due to advances in technology. This research is in its infancy; and the relationship of the work setting and behaviour, and how it affects productivity, is said to be complex.The existing data suggest that non‐supportive design has negative effects on work and workers, and design appropriate to the work has positive ones. In fact, many businesses have begun changing their design and organizational cultures with positive results. Only time and more observation can reveal what will result from these changes.
Spatial Decision Support System for Urban Planning: Case Study of Harbin City in China

Urban land structure, layout, and land-use mode influence regional sustainable development greatly. However, planners usually cannot work perfectly because of insufficient environmental information for decision making. In recent years, with urban geographic information system (GIS) development many cities have already built up integrated urban information platform to support regional digitalization process. By using spatial data mining technology urban planning related knowledge can be discovered form GIS database to help planners and decision makers in their work. Through analyzing of Chinese cities’ construction mode and developing trend, this paper illustrates how to build up an urban planning spatial decision support system (UPSDSS) based on exploratory spatial data analysis technology support. By spatial data mining form GIS database, UPSDSS can provide related knowledge for urban planning decision making with inference engines (rule inference and case inference) support. As an important part of the .
Overload protection for medium voltage motors controlled by switchgear starters

The author addresses the application of traditional types of overload protective devices, notes some of the difficulties in doing so, and then recommends the better types. It is suggested that a combination of relays may be the best answer. Microprocessor relays, with good memory characteristics, are probably the best protection that can be applied, but they must be studied closely to be properly set. Some of them are furnished with the possibility of custom-building the protection curve. It is noted that this is much easier then to fit the curve including overload, start, and stall protection between the motor start run curve and the motor thermal withstand curve, which is the ultimate overload protection. <<ETX>>
A 2 DOF vibration harvester for broadband and multifrequency harvesting using a single electro-magnetic transducer

The narrow bandwidth of resonant vibration energy harvesters has long been seen as a drawback to exploitation. The narrow bandwidth is necessitated by the requirement to sufficiently amplify small source vibrations, but results in devices vulnerable to changes in excitation frequency, de-tuning due to ageing of components, and also makes efficient harvesting from sources with multiple frequency components difficult. In this paper a harvester based on a 2 degree of freedom oscillator is presented that not only enjoys the wider bandwidth of the higher order system, but configures the electromagnetic transducer in such a way that it requires no more components than the transducer of a typical single degree of freedom harvester. Theoretical models of the harvester system predict a range of possible frequency response functions dependent on easily-adjusted electrical parameters. These predictions are validated with experimental results.
Process, voltage and temperature compensation in a 1-MHz 130nm CMOS monolithic clock oscillator with 2.3% accuracy

This paper presents an on-chip process, voltage and temperature (PVT) compensation technique for a 1-MHz monolithic clock oscillator in a CMOS process. The oscillator is based on carrier mobility and frequency-to-voltage converter (FVC), which is based on charge pump circuit. An adaptive charge current maintains a constant frequency without trimming. Furthermore, a reference voltage with a second-order temperature coefficient further compensates the variation of frequency with temperature. It improves the accuracy of existing carrier-mobility-based oscillator, from 4.5% to 2.3%. The circuit was designed in a 130 nm CMOS 3.3 V device process. The results show that the output frequency is within 2.3% variation in the worst case. The variations of frequency with process, temperature (−40 to 125°C) and power supply are within 1.8%, 0.8% and 0.2%/V, respectively. It achieves a CMOS monolithic clock oscillator insensitive to PVT.
Mode Monitoring and Call-Outs: An Eye-Tracking Study of Two-Crew Automated Flight Deck Operations

Mode awareness has been suggested as a critical factor in safe operations of automated aircraft. This study investigated mode awareness by measuring eye point of gaze of both pilots during simulated commercial flights, while recording call-outs and tracking aircraft performance. The results of this study show that the compliance to manufacturer or air carrier procedures regarding mode monitoring and call-outs was very low. However, this did not seem to have a negative effect on the flight path or safety during our observations. Crews exhibited a proliferation of strategies to keep track of status and behavior of the automation, often with little reliance on the flight mode annunciations of the primary flight display. The data confirm the limitations of current flight mode annunciator designs, and suggest that mode awareness is a more complex phenomenon than what can be captured by measuring eye point of gaze and communication alone.
Impacts of Phantom Off-Center Positioning on CT Numbers and Dose Index CTDIv: An Evaluation of Two CT Scanners from GE

The purpose of this work is to evaluate the impacts of body off-center positioning on CT numbers and dose index CTDIv of two scanners from GE. HD750 and APEX scanners were used to acquire a PBU60 phantom of Kagaku and a 062M phantom of CIRS respectively. CT images were acquired at various off-center positions under automatic tube current modulation using various peak voltages. CTDIv were recorded for each of the acquisitions. An abdomen section of the PBU60 phantom was used for CT number analysis and tissue inserts of the 062M phantom were filled with water balloons to mimic the human abdomen. CT numbers of central regions of interests were averaged using the Fiji software. As phantoms were lifted above the iso-center, both CTDIv and CT numbers were increased for the HD750 scanner whilst they were approximately constant for the APEX scanner. The measured sizes of anterior-posterior projection images were also increased for both scanners whilst the sizes of lateral projection images were increased for the HD750 scanner but decreased for the APEX scanner. Off-center correction algorithms were implemented in the APEX scanner. Matching the X-ray projection center with the system’s iso-center could improve the accuracy of CT imaging.
Potential Retrofitting of Existing Campus Buildings to Green Buildings

Green building is building that the focus is to maximize the energy efficiency and resources used. While, retrofitting is the process of renovate or refurnish the existing building. Therefore by retrofit existing buildings that comply with green building requirement, it improves the environmental attributes of the buildings. In Malaysia, existing buildings and its communities contribute over 40% of green house gases to the environment. This paper describes a study that explores the potential to retrofit existing campus buildings that response to sustainable green building standard. A validation survey was carried out and the data collected was analysed using SPSS in order to confirm the significance of retrofitting Universiti Teknologi Malaysia (UTM) buildings toward green building initiative. The results show that all the twenty eight identified green elements recorded average index of higher than 3.5 which means that there is significant needs to retrofit the existing buildings to green buildings. This study concludes that it is urgently need for the campus to response to green building requirements in order to achieve higher energy effeciency and this can be done through effective etrofitting of existing buildings.
Guaranteed cost H infinity control of multi-time-delayed discrete-time linear system with modeling uncertainties and disturbance

This paper considers the networked control problem of a class of discrete-time linear system with noise disturbance and modeling uncertainties. Based on guaranteed cost control theory and dynamic dissipative control theory, the sufficient conditions for the system to be stabilizable by memoryless state feedback controller are given. In terms of linear matrix inequality (LMI) method, we demonstrate that the controller can be designed by a simple procedure. Compare with the existed papers which studied the system with modeling uncertainties or time-delay or noise disturbance, this paper considers not only modeling uncertainties and multiple time-delay, but also exterior noise disturbance in Networked Control system (NCS).
A simulated annealing technique for multiobjective optimization of intelligent structures

A multiobjective optimization procedure is developed to address the combined problems of the synthesis of structures/controls and the actuator-location problem for the design of intelligent structures. Continuous and discrete variables are treated equally in the formulation. Multiple and conflicting design objectives such as vibration reduction, dissipated energy, power and a performance index are included by utilizing an efficient multiobjective optimization formulation. Piezoelectric materials are used as actuators in the control system. A simulated annealing algorithm is used for optimization and an approximation technique is used to reduce computational effort. A numerical example using a cantilever box beam demonstrates the utility of the optimization procedure when compared with a previous nonlinear programming technique.
Machined waveguide twist

A solution to the problem of obtaining a 90 degrees twist in a machined-aluminium block waveguide is presented. At the waveguide input, half the waveguide wide-dimension is machined into one aluminum block the mirror image being machined into a second block. The technique involves gradually reducing the width of the input waveguide in one block, and simultaneously increasing the depth of the waveguide in the opposite block until the output waveguide depth is equal to the input waveguide width. Care must be taken to maintain a constant waveguide cutoff frequency through the length of the twisted section so that a good match is obtained. Two twists made using this technique in WR-22 waveguide are shown to give satisfactory results. >