Miracle-dz/UniFAR-FTUs huggingface dataset:
Flexible BaTiO3-PDMS Capacitive Pressure Sensor of High Sensitivity with Gradient Micro-Structure by Laser Engraving and Molding

The significant potential of flexible sensors in various fields such as human health, soft robotics, human–machine interaction, and electronic skin has garnered considerable attention. Capacitive pressure sensor is popular given their mechanical flexibility, high sensitivity, and signal stability. Enhancing the performance of capacitive sensors can be achieved through the utilization of gradient structures and high dielectric constant media. This study introduced a novel dielectric layer, employing the BaTiO3-PDMS material with a gradient micro-cones architecture (GMCA). The capacitive sensor was constructed by incorporating a dielectric layer GMCA, which was fabricated using laser engraved acrylic (PMMA) molds and flexible copper-foil/polyimide-tape electrodes. To examine its functionality, the prepared sensor was subjected to a pressure range of 0–50 KPa. Consequently, this sensor exhibited a remarkable sensitivity of up to 1.69 KPa−1 within the pressure range of 0–50 KPa, while maintaining high pressure-resolution across the entire pressure spectrum. Additionally, the pressure sensor demonstrated a rapid response time of 50 ms, low hysteresis of 0.81%, recovery time of 160 ms, and excellent cycling stability over 1000 cycles. The findings indicated that the GMCA pressure sensor, which utilized a gradient structure and BaTiO3-PDMS material, exhibited notable sensitivity and a broad linear pressure range. These results underscore the adaptability and viability of this technology, thereby facilitating enhanced flexibility in pressure sensors and fostering advancements in laser manufacturing and flexible devices for a wider array of potential applications.
Using tracer data to calibrate a flexible, topography driven conceptual hydrological model

This study explores the possibility of calibrating a conceptual hydrological model to tracer (Oxygen-18) data measured in streamflow with the ultimate goal to predict discharge. The hypothesis is that (changes in) Oxygen-18 concentrations in the stream should tell something about the relative contribution of fast runoff compared to slow runoff (groundwater flow) inside the stream. A conceptual hydrological model incorporating both tracer dynamics and discharge should be able to model this. Using tracer previously measured in the Brugga catchment (South-West Germany) by people of the University of Freiburg, both lumped and FLEX-Topo inspired models are developed and calibrated to this data. Results showed that of all models considered, only a FLEX-Topo inspired model, containing a variable groundwater level that is able to occasionally (partially or wholly) submerge the wetland model structure, was able to predict a decent hydrograph when calibrating purely on tracer data. The results indicate that calibration of a FLEX-Topo inspired model to only tracer data is a real possibility, and opens the door to more sophisticated modelling attempts, for instance calibration on multiple tracers or multiple tracer sampling points.
Synthesis of silver nanoparticles formed by Chaerophyllum macrospermum and Eremurus spectabilis biomaterial and investigation of photovoltaic parameters by adding silicon phthalocyanine

Abstract Silver nanoparticles (AgNPs) were obtained by green synthesis using Chaerophyllum macrospermum (CM) and Eremurus spectabilis (ES). These particles were characterized by TEM, XRD, IR, UV, mass, and NMR spectra. TEM images show that the mean particle size of CM-AgNPs was 30 nm and the diameter of ES-AgNPs was 14.2 nm. XRD measurements showed that CM-AgNPs were 30.85 nm and ES-AgNPs 18.80 nm in a perfect face-centered cubic crystal structure. CM-AgNP showed maximum absorption at 453 nm and ES-AgNP at 455 nm; AgNPs exhibited a strong surface plasmon resonance (SPR) and played a role in stabilization. A silicon phthalocyanine compound was synthesized and characterized. The photovoltaic properties of the axial phthalocyanine compound with and without doping of Chaerophyllum macrospermum and Eremurus spectabilis silver nanoparticles were investigated. Better dye-sensitive solar cells were formed by doping silver nanoparticles to phthalocyanine compounds with an increase in the percentage of energy conversion efficiency by 0.26 with ESAgNP doping and 0.76 with CMAgNP doping. Graphical abstract
Research progress of mitophagy in chronic cerebral ischemia

Chronic cerebral ischemia (CCI), a condition that can result in headaches, dizziness, cognitive decline, and stroke, is caused by a sustained decrease in cerebral blood flow. Statistics show that 70% of patients with CCI are aged > 80 years and approximately 30% are 45–50 years. The incidence of CCI tends to be lower, and treatment for CCI is urgent. Studies have confirmed that CCI can activate the corresponding mechanisms that lead to mitochondrial dysfunction, which, in turn, can induce mitophagy to maintain mitochondrial homeostasis. Simultaneously, mitochondrial dysfunction can aggravate the insufficient energy supply to cells and various diseases caused by CCI. Regulation of mitophagy has become a promising therapeutic target for the treatment of CCI. This article reviews the latest progress in the important role of mitophagy in CCI and discusses the induction pathways of mitophagy in CCI, including ATP synthesis disorder, oxidative stress injury, induction of reactive oxygen species, and Ca2+ homeostasis disorder, as well as the role of drugs in CCI by regulating mitophagy.
THE EFFECT OF NCO/OH EQUIVALENT WEIGHT RATIOS OF POLYURETHANE (PU) BINDER AND PU BINDER CONTENT ON PROPERTIES OF MEDIUM DENSITY FIBERBOARD (MDF)

The potential of using bio-based binders for medium density fiberboard (MDF) has received increased attention. However, no study was done on the potential of palm-based polyurethane (PU) as biobased binder in MDF. Therefore, an investigation on the effect of equivalent weight ratios of isocyanate (NCO) and hydroxyl group (OH) of palm oil-based PU binder and binder content on the properties of MDF was conducted. Palm oil-based PU binders were prepared at different equivalent weight ratios of NCO and OH at 1.5/1 (PU1.5), 2.0/1 (PU2.0) and 2.5/1 (PU2.5) and binder content at 3%, 5%, 7% and 10% were used in the preparation of MDF. The polyol, NCO and palm oil-based PU binders were characterised using Fourier transform infrared spectroscopy and thermogravimetric analysis. As equivalent weight ratios of NCO and OH and binder content increased, the modulus of rupture, modulus of elasticity and internal bonding of MDF were consistently increased. Thickness swelling and moisture content decreased with increased equivalent weight ratios of NCO and OH and binder content. In general, MDF prepared with PU2.0 with 7% binder content fulfills all British Standard (BS EN 622-5, 2009) requirements, indicating its suitability for MDF application.
Are eruptions reliable precursors to marine volcano collapses?

Volcanoes are sources of numerous threats including lava flows, pyroclastic flows, ash dispersal and landslides or sector collapses. In addition to these commonly known volcanic hazards, volcano-induced tsunamis can occur in the marine environment, introducing a major hazard that can affect populations located far away from the volcanoes. Existing tsunami warning systems generally do not account for volcano-generated tsunamis, due to the multiple source mechanisms that can cause such tsunamis, a limited understanding of precursory signals for these events, and the need for local detection rather than remote sensing. Among these source mechanisms of volcanic tsunamis, sector and lateral collapses are at the high risk-low frequency extreme of risk matrices. Marine volcanoes grow in specific environments, with factors like marine clays, constant full saturation, sediment transport and remobilization, interaction with ocean dynamics, and sea level changes that may impact edifice stability in distinct ways. The majority of historically documented marine volcano collapses occurred at erupting volcanoes, suggesting that eruptions could serve as a remotely detectable warning signal for collapses. However, careful examination of temporal sequences of these examples reveals that collapses do not always follow eruptions. Consequently, there is a need for identifying other, more robust precursors to volcano collapse, in particular in the marine environment, where the consequences of collapses may be widespread.
TUBB3 and KIF21A in neurodevelopment and disease

Neuronal migration and axon growth and guidance require precise control of microtubule dynamics and microtubule-based cargo transport. TUBB3 encodes the neuronal-specific β-tubulin isotype III, TUBB3, a component of neuronal microtubules expressed throughout the life of central and peripheral neurons. Human pathogenic TUBB3 missense variants result in altered TUBB3 function and cause errors either in the growth and guidance of cranial and, to a lesser extent, central axons, or in cortical neuronal migration and organization, and rarely in both. Moreover, human pathogenic missense variants in KIF21A, which encodes an anterograde kinesin motor protein that interacts directly with microtubules, alter KIF21A function and cause errors in cranial axon growth and guidance that can phenocopy TUBB3 variants. Here, we review reported TUBB3 and KIF21A variants, resulting phenotypes, and corresponding functional studies of both wildtype and mutant proteins. We summarize the evidence that, in vitro and in mouse models, loss-of-function and missense variants can alter microtubule dynamics and microtubule-kinesin interactions. Lastly, we highlight additional studies that might contribute to our understanding of the relationship between specific tubulin isotypes and specific kinesin motor proteins in health and disease.
Burden of disease and injury in Aboriginal and Torres Strait Islander Peoples: the Indigenous health gap.

BACKGROUND Disparities in health status between Aboriginal and Torres Strait Islander peoples and the total Australian population have been documented in a fragmentary manner using disparate health outcome measures. METHODS We applied the burden of disease approach to national population health datasets and Indigenous-specific epidemiological studies. The main outcome measure is the Indigenous health gap, i.e. the difference between current rates of Disability-Adjusted Life Years (DALYs) by age, sex and cause for Indigenous Australians and DALY rates if the same level of mortality and disability as in the total Australian population had applied. RESULTS The Indigenous health gap accounted for 59% of the total burden of disease for Indigenous Australians in 2003 indicating a very large potential for health gain. Non-communicable diseases explained 70% of the health gap. Tobacco (17%), high body mass (16%), physical inactivity (12%), high blood cholesterol (7%) and alcohol (4%) were the main risk factors contributing to the health gap. While the 26% of Indigenous Australians residing in remote areas experienced a disproportionate amount of the health gap (40%) compared with non-remote areas, the majority of the health gap affects residents of non-remote areas. DISCUSSION Comprehensive information on the burden of disease for Indigenous Australians is essential for informed health priority setting. This assessment has identified large health gaps which translate into opportunities for large health gains. It provides the empirical base to determine a more equitable and efficient funding of Indigenous health in Australia. The methods are replicable and would benefit priority setting in other countries with great disparities in health experienced by Indigenous peoples or other disadvantaged population groups.
Genetic diversity and relationship of mango and its wild relatives (Mangifera spp.) based on morphological and molecular markers

ABSTRACT Mango and its wild relatives (Mangifera spp.) are essential for future mango breeding, including preservation programs, because they provide many beneficial genes (agronomic traits), particularly those related to resistance to biotic and abiotic stressors. However, there is a limited understanding of the genetic diversity and relationships of this germplasm. This study aimed to determine the diversity and relationship between endemic mango and its wild relatives (Mangifera spp.) from Borneo Island, Indonesia, using leaf morphology and the internal transcribed spacer (ITS) region. Fifteen samples of Mangifera, covering 12 species, were used. Morphologically, the endemic Mangifera had a low diversity of only 0.22. Based on the ITS sequence, Mangifera endemic to Borneo had a high level of genetic diversity (0.069). In addition, this sequence had a total variable number of 215 bp, of which 110 bp were singleton sites, 89 informative parsimony and 41 indels. Phylogenetic analysis showed that Mangifera was grouped into three clusters for leaf morphological traits and four clades for the ITS region. In this case, the furthest relationship was pointed out by ‘Hampalam’ (M. laurina) and ‘Tambusui’ (M. macrocarpa), as well as by ‘Rawa-Rawa’ (M. similis) and ‘Samputar’ (M. torquenda). In contrast, the closest relationship was shown by ‘Hambawang Damar’ (M. foetida) and ‘Hambawang Puntara’ (M. foetida), including ‘Samputar’ (M. torquenda) and ‘Pauh’ (M. quadrifida). In particular, the common mango (M. indica) was closely related to ‘Asam Buluh’ and ‘Hampalam’ (M. laurina) and distantly related to ‘Pauh’ (M. quadrifida) and ‘Rawa-Rawa’ (M. similis).
Portsmouth: a window on the world?

In 2002 the annual conference of the Society for Post-Medieval Archaeology was directed at a theme of international interest, Cities in the World, 1500-2000. This volume results from that conference and sets out to investigate a wide range of new archaeological and historical approaches to the development of large towns and cities in Britain, Europe and the World in the early modern period. Post-Medieval archaeologists working in European contexts should find much of interest in the experiences, investigations and interpretations of 19th and 20th century cities such as Boston, Jamestown and New York in North America and Sydney in Australia. Papers drawing upon recent research provide a contemporary international perspective on recent research in urban historical archaeology.
Maternal taurine as a modulator of Cl– homeostasis as well as of glycine/GABAA receptors for neocortical development

During brain and spinal cord development, GABA and glycine, the inhibitory neurotransmitters, cause depolarization instead of hyperpolarization in adults. Since glycine and GABAA receptors (GABAARs) are chloride (Cl–) ion channel receptor, the conversion of GABA/glycine actions during development is influenced by changes in the transmembrane Cl– gradient, which is regulated by Cl– transporters, NKCC1 (absorption) and KCC2 (expulsion). In immature neurons, inhibitory neurotransmitters are released in a non-vesicular/non-synaptic manner, transitioning to vesicular/synaptic release as the neuron matures. In other word, in immature neurons, neurotransmitters generally act tonically. Thus, the glycine/GABA system is a developmentally multimodal system that is required for neurogenesis, differentiation, migration, and synaptogenesis. The endogenous agonists for these receptors are not fully understood, we address taurine. In this review, we will discuss about the properties and function of taurine during development of neocortex. Taurine cannot be synthesized by fetuses or neonates, and is transferred from maternal blood through the placenta or maternal milk ingestion. In developing neocortex, taurine level is higher than GABA level, and taurine tonically activates GABAARs to control radial migration as a stop signal. In the marginal zone (MZ) of the developing neocortex, endogenous taurine modulates the spread of excitatory synaptic transmission, activating glycine receptors (GlyRs) as an endogenous agonist. Thus, taurine affects information processing and crucial developmental processes such as axonal growth, cell migration, and lamination in the developing cerebral cortex. Additionally, we also refer to the possible mechanism of taurine-regulating Cl– homeostasis. External taurine is uptake by taurine transporter (TauT) and regulates NKCC1 and KCC2 mediated by intracellular signaling pathway, with-no-lysine kinase 1 (WNK1) and its subsequent kinases STE20/SPS1-related proline-alanine-rich protein kinase (SPAK) and oxidative stress response kinase-1 (OSR1). Through the regulation of NKCC1 and KCC2, mediated by the WNK-SPAK/OSR1 signaling pathway, taurine plays a role in maintaining Cl– homeostasis during normal brain development.
Ecological significance of standing dead phytomass: Marcescence as a puzzle piece to the nutrient cycle in temperate ecosystems

The plant economics spectrum (PES) drives nutrient cycling through effects on soil decomposers. However, dead phytomass may remain standing or unshed (marcescent), hardly accessible to decomposers and be photodegraded. In arid zones, the significant part of marcescent phytomass can be decomposed without touching the ground. In temperate zones, photodegradation of marcescent phytomass is low but prompts important chemical changes, which affect its subsequent decomposability in the soil and alters the surrounding environment. It is unknown, however, how common marcescence is among different taxa and in which habitats, and how it is coordinated by PES traits. We sampled standing (marcescent) and lying (shed) dead phytomass from a broad spectrum of 127 herbaceous temperate species in a common garden experiment and related these parameters to PES traits, species ecological preferences and phylogeny. Nearly all species (97%) kept their phytomass marcescent. Tall species with a small leaf area and high leaf carbon had a high level of marcescence. Marcescent species also preferred sites affected by severe (but not necessarily frequent) disturbance. The degree of marcescence was considerably conserved in phylogeny. Synthesis. Marcescence extends PES trait effects on ecosystems, particularly in immature habitats, being a common but overlooked phenomenon of the temperate flora.
A Review on the Crosstalk between Insulin and Wnt/β-Catenin Signalling for Bone Health

A positive association between insulin resistance and osteoporosis has been widely established. However, crosstalk between the signalling molecules in insulin and Wingless (Wnt)/beta-(β-)catenin transduction cascades orchestrating bone homeostasis remains not well understood. The current review aims to collate the existing evidence, reporting (a) the expression of insulin signalling molecules involved in bone-related disorders and (b) the expression of Wnt/β-catenin signalling molecules involved in governing insulin homeostasis. The downstream effector molecule, glycogen synthase kinase-3 beta (GSK3β), has been identified to be a point of convergence linking the two signal transduction networks. This review highlights that GSK3β may be a drug target in the development of novel anabolic agents and the potential use of GSK3β inhibitors to treat bone-related disorders.
APPLICATION MULTIPLEX PCR FOR EARLY DETECTION ESCHERICHIA COLI CONTAMINATION IN SOME DRINKING WATER RESOURCES IN ABEPURA, PAPUA INDONESIA

Abstract Microbial detection takes a long time to produce positive results, so a quicker detection method was chosen. Multiplex polymerase chain reaction (m-PCR) identified bacterial strains in less than 24 hours, detects E.coli specifically, and is faster than traditional methods. The goal of this study was to use m-PCR to detect early pathogenic E.coli bacteria in several drinking water sources in the Abepura district of Papua Indonesia as a parameter of pollution and water quality. The Chelex100 and microwave combination method was used to extract DNA. The first round of testing was done at four different concentrations: 0.125, 0.250, 0.375, and 0.500 M. The purity of the extracted DNA was good, ranging from 1.80 to 1.94. The optimum primer concentration for multiplexing applications is 0.25 uM for lt primer; 0.125 uM for stx2 and eae primer, with an annealing temperature of 55oC. m-PCR has been shown to quickly detect pathogenic E. coli in water samples. In the PCR process, E.coli DNA template was obtained with high purity (1.80-1.94) and concentration (576.9-4301.6 ng/uL) . Each multiplex set included three primer pairs for the target gene lt-eae-stx2 on ETEC-EPEC and EHEC respectively. The m-PCR process showed excellent results, and this findings can be considered as a reference for water analysis in several drinking sources in Papua Province.
Optimality conditions via a unified direction approach for (approximate) efficiency in multiobjective optimization

The presented paper addresses scalarization techniques for multiobjective optimization problems. A new scalarization technique for solving a general multiobjective optimization problem is proposed. This scalarization method is called the unified direction method, because it generalizes the Pascoletti–Serafini approach (direction approach). Some theoretical results related to the suggested scalarization technique are established, especially the ability of the method for generating (properly, weakly) efficient solutions is shown. Moreover, the relation between approximate optimal solutions of the proposed single objective problem and approximate (weakly, properly) efficient solutions of the multiobjective optimization problem is investigated. In fact, easy-to-check, necessary and sufficient conditions for ϵ-(weak, proper) efficiency are obtained. Moreover, the effectiveness of the proposed approach is illustrated with some illustrative computational examples.
Joint Resource Allocation for User-Centric Cell-Free Integrated Sensing and Communication Systems

The cell-free massive multiple-input multiple-out (MIMO) is an appealing architecture for supporting integrated sensing and communication (ISAC), since its macro diversity can resist the large-scale fading and enhance the detection probability. This letter focuses on user-centric cell-free massive MIMO ISAC system, which is jointly designed with the vector orthogonal frequency division multiplexing integrated signal. We set the sum-rate of the proposed ISAC system as the unified metric, and investigate a joint user scheduling and power allocation scheme. We effectively relax the non-convex resource allocation issue as a linear fractional program. Subsequently, we introduce a low-complexity branch and bound algorithm based on piecewise concave overestimating functions, which can efficiently maximize the sum-rate. Simulation results demonstrate that our proposed system provides superior sum-rate performance than the centralized and classical cell-free counterparts.