Miracle-dz/UniFAR-FTUs huggingface dataset:
High-Pressure Technologies for the Recovery of Bioactive Molecules from Agro-Industrial Waste

Large amounts of food waste are produced each year. These residues require appropriate management to reduce their environmental impact and, at the same time, economic loss. However, this waste is still rich in compounds (e.g., colorants, antioxidants, polyphenols, fatty acids, vitamins, and proteins) that can find potential applications in food, pharmaceutical, and cosmetic industries. Conventional extraction techniques suffer some drawbacks when applied to the exploitation of food residues, including large amounts of polluting solvents, increased time of extraction, possible degradation of the active molecules during extraction, low yields, and reduced extraction selectivity. For these reasons, advanced extraction techniques have emerged in order to obtain efficient residue exploitation using more sustainable processes. In particular, performing extraction under high-pressure conditions, such as supercritical fluids and pressurized liquid extraction, offers several advantages for the extraction of bioactive molecules. These include the reduced use of toxic solvents, reduced extraction time, high selectivity, and the possibility of being applied in combination in a cascade of progressive extractions. In this review, an overview of high-pressure extraction techniques related to the recovery of high added value compounds from waste generated in food industries is presented and a critical discussion of the advantages and disadvantages of each process is reported. Furthermore, the possibility of combined multi-stage extractions, as well as economic and environmental aspects, are discussed in order to provide a complete overview of the topic.
Boundary-Spanning in Disaster Risk Reduction and Recovery through Solution-Focused Coaching Approach

Universities must forge new links, form coalitions and facilitate engagement with local stakeholders to reduce future natural disaster impacts. This paper introduces a conceptual framework and key features of an integrated model of boundary-spanning strategies and solution-focused coaching (SFC) approach in disaster risk reduction and recovery (DRRR). The model is based on stakeholders’ strengths, relationship-building. It is a goal setting approach in DRRR that uses boundary spanning strategies to empower multi-stakeholders in envisioning a more resilient community in the face of future disaster. Through stakeholders-community boundary spanners collaborations, DRRR shared goals and plans are co-produced. Keywords: Boundary-spanning, solution-focused coaching, disaster risk reduction and recovery eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v7i19. 3208
Recommendations to Improve African-American/Black Students’ Experiences and Achievement in Asynchronous Online Community College Courses

ABSTRACT This brief is rooted in the purpose and findings of a qualitative study that explored the experiences and perspectives of African-American/Black community college students in asynchronous online learning environments. A growing number of African-American/Black students are enrolling in California community colleges and online courses. However, African-American/Black students have disproportionately poor academic outcomes in online community college courses, and little is known regarding their online learning experiences. Key recommendations in this brief center on the importance of promoting and investing in online student services, providing opportunities for online student communities, and investing in ongoing online faculty training.
Forecasting California Pesticide Demand using PUR Dataset

Pesticide use related to agriculture and non-agricultural uses has increased six-fold during the last three decades. California has been collecting pesticide use since 1990, and that is recognized as the most comprehensive pesticide reporting program in the world. The program includes the information for 1003 active ingredients and 309 end use commodities. This study aims to develop a relationship between end uses and chemicals to determine the possible impact of end-uses for pesticide demand. In this study, we develop a comprehensive relationship between the pesticide end-uses and active ingredients and analyze pesticide demand using the historical data available from the PUR dataset and agricultural production data using stochastic simulation methods.
Nutritional support practices at an intensive care unit in Johannesburg, South Africa

Objectives: Nutritional support is a fundamental component of holistic patient care in the intensive care unit (ICU). There is a paucity of local data pertaining to nutritional support practices at ICUs in South Africa. The aim of this study was to determine nutritional support practices at an academic hospital ICU in Johannesburg, South Africa. Methods: In this cross-sectional, descriptive and retrospective study, a simple random sampling method was utilised to select 50 data collection days from a three-month period (1 August–31 October 2018). Data relevant to the study were extracted from the ICU charts of patients who received formulae-based enteral and/or parenteral nutrition on the selected days. Charts were categorised into acute phase days (≤ 72 hours from ICU admission) and recovery phase days (> 72 hours from ICU admission). Results: A total of 387 ICU charts were included in the final sample, comprising 114 acute phase and 273 recovery phase days. Overall, enteral nutrition was prescribed on 296 (76.5%) chart days while parenteral nutrition was prescribed on 111 (28.7%) chart days. The median daily fluid balance was approximately 600 ml positive. Target protein and calorie intake was achieved on 67 (17.3%) and 110 (28.4%) chart days respectively. Conclusion: Although protein and calorie intake was suboptimal in comparison with the recommended targets, it is in keeping with general international trends. Regular audits, training of staff, attention to minimising feeding interruptions and encouraging the timely initiation of enteral nutrition are recommended interventions that may be useful in achieving nutritional targets.
YB-1 as an Oncoprotein: Functions, Regulation, Post-Translational Modifications, and Targeted Therapy

Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD) that also belongs to the family of DNA- and RNA-binding proteins. YB-1 is present in both the nucleus and cytoplasm and plays versatile roles in gene transcription, RNA splicing, DNA damage repair, cell cycle progression, and immunity. Cumulative evidence suggests that YB-1 promotes the progression of multiple tumor types and serves as a potential tumor biomarker and therapeutic target. This review comprehensively summarizes the emerging functions, mechanisms, and regulation of YB-1 in cancers, and further discusses targeted strategies.
The Effect of Accumulation of Leaf Litters and Allelochemicals in the Soil to the Sustainability of the Newly Introduced Crop Plants

Indonesia is the second-largest vanilla production and the third-largest cocoa production in the world, but it sustained for a short period. The unsustainability of these crops is speculated to occur because of the change in leaf litter accumulation which affected the sustainability of soil organic carbon that plays an important role in maintaining soil health and fertility. To find out methods that could improve the sustainability of the production, a literature review was conducted. The articles, related to the sustainability of vanilla and cacao production, were collected using Google Scholar, Wiley Online Library, ResearchGate, and Google Chrome browser. Keywords were employed to find the articles includingsoil organic carbon, cocoa plantation, vanilla, leaf litter, and allelochemical. This current article review foundthat introducing crop by clearing of previously existing vegetation could severely reduce the rate of leaf litter accumulation. Consequently, in a prolonged period, the soil organic carbon and soil fertility are very low and are unable to support the healthy growth and production of the crops. To restore production, the plantation then is returned to more traditional agroforestry such as replanting shading trees and addition of mulch. However, in the higher density of canopy, the crop production is low attributed partly to the decreasing soil pH which increases the impact of allelochemical. This review concluded that the sustainability of leaf litter accumulation is crucial to maintain soil health, but mitigation is required to reduce the impact of allelochemical accumulation.
Field Pull-Out Test and Analysis of Fiberglass Anchors in Sanshandao Gold Mine

The Sanshandao gold mine is developed near the sea and has high-chloride ion content in the groundwater, resulting in serious corrosion of metal anchors and difficulty in maintaining metal anchors. To solve the corrosion problem of anchor rods in Sanshandao, the use of fiberglass anchor rods, instead of metal anchor rods, is proposed. To verify the feasibility of fiberglass anchor application, a fiberglass anchor (diameter: 27 mm) pulling test was conducted at the Sanshandao gold mine. The test results show that (1) the pull-out resistance of fiberglass anchor rods is better than those of metal pipe slit anchor rods and threaded anchor rods currently used in the Sanshandao gold mine; (2) the failure of fiberglass anchor rods is mainly because of the destruction of anchor washer discs and nuts, whose rods play only 69.90–77.7% of their performance and remain intact; (3) the fiberglass anchor rod was damaged to different degrees several times before the pulling failure, and the damage was accompanied by sound; (4) the fiberglass anchor continued to bear pressure after each damage until complete failure occurred; and (5) the anchor washer disc relative to the nut to allow the pressure effect can avoid nut pressure collapse and improve the pulling performance of the anchor rod to a certain extent simultaneously. Through the test, it was proved that the 27 mm fiberglass anchor can meet the support demand of the Sanshandao gold mine. It also provides an important reference for the promotion and application of fiberglass anchor rods in similar mines.
The Cooch Behar -Assam Tornado of 19 April 1963

The physical, meteorological and kinematical aspects of a severe tornado that occurred in Coach Behar-Assam area on 19 April 1963 are studied in the present paper with the aid of available survey reports and meteorological data, It is e3tlmated that the pressure defect inside the tornado war about 100 millibars, the strength of the updraft was 165 knots, and the tangential velocity of rotation was 184 knows. The Vortex motion inside the evaluating tornado is discussed.
Stigma Music of Human Life in Indonesia Orchestral Music

Music continues to surround human life from time to time; music is inextricably linked to human life from the moment man is born. Music also plays a role in bringing changes to human life in a better direction and maybe vice versa. In our daily lives, we cannot avoid the sounds or vibrations that come to our ears through the strains of music. Our lives are approached by music wherever we are. Music is a part of our lives. The researcher here wants to find out more about how the music process develops over time and its stigma to the operation of social change in society with the concept of musicology with qualitative methods, where the stigma of music tends to go, how researcher wants to better understand music by using methods of theoretical anthropological studies from time to time until the birth of music, on the other hand, what changes happen after the music is born. Stigma against music has certainly affected social life in society. Stigma towards more popular music such as orchestral music is one of the music whose bearer style is more likely to be passionate in the listener. Here the author wants to invite the music listener community to hear and explore the meaning of music and bring an appreciation stigma to his life. In addition, the author seeks to confirm that the music listener community can listen and explore the meaning of music and bring a positive stigma to his life. In addition, the author also would like the songwriters to explore more songs that stigmatize music by continuing to support people's appetite for a better humanity.
Differences in Physical Characteristics of the Lower Extremity and Running Biomechanics Between Different Age Groups

(1) Background: The objective of this study was to determine physical and biomechanical changes in age groups upon running. (2) Method: 75 male adults (20–80s) participated in the study. Bone mineral density and lower extremity joint strength were measured according to age-increase targeting. Based on age, correlations among running characteristics, impulse, impact force, maximum vertical ground reaction force, loading rate, lower extremity joint 3D range of motion, joint moment, and power upon running motion were calculated. (3) Result: Older runners tended to show lower bone mineral density, extremity maximum strength, stride time, and stride distance, with smaller RoM and joint power of ankle and knee joints in the sagittal plane, compared with younger subjects. However, there were no significant correlations between age and impact variables (i.e., impulse, impact force, peak GRF, and loading rate) during running. (4) Conclusion: Older runners tend to show weaker physical strength characteristics, such as bone mineral density and muscle strength and lower joint functionality of ankle and knee joints during running, compared with younger runners. Therefore, strengthening the lower extremity muscle and improving dynamic joint function, especially for ankle joints, can be helpful for injury prevention during running.
Observing the Developmental Progression of Pretend Play across the Preschool Years

ABSTRACT Pretend play is an important, universal activity of early childhood, but research to date contains multiple inconsistencies in definitions and measurement of pretend play. To begin to resolve this issue, we conducted a first study of the multiple different behaviors of pretend play in the preschool years (3–5 years), and investigated their developmental progression. Pretend play can be defined by five core behaviors, theorized to develop in this order: object substitution, attributing pretend properties, social interactions, role play, and metacommunication. We created a new observational measure to capture all five simultaneously for the first time, and used this measure in 34 hours of naturalistic observation of preschoolers (N = 73) engaged in play. Children’s age was a significant, positive predictor of engagement in the higher-level pretense behaviors (social interactions, role play, metacommunication), and of engagement in multiple behaviors simultaneously. This study provides initial support for the theorized developmental progression of pretend play and provides a framework for future research.
Prevalence and type of injuries among gym members in Saudi Arabia

Introduction: Strenuous exercise and misuse of fitness machines can lead to injury. We conducted this study to better understand the extent of the problem and identify the causes of injuries, so we can develop and implement preventive measures to reduce the risk of injuries. Methods: A cross-sectional study was conducted through a self-filled online questionnaire prepared in Arabic. The questionnaire was distributed through social media to gym members between 18 and 55 years old. Results: In this study, we were able to collect 285 responses to our questionnaire. Most of the participants were females (71.6%) and more than half of the respondents were between 25 and 34 years of old (54.4%). The reliability results of the questionnaire showed that Cronbach's alpha was 0.749. Considering the prevalence of injuries among gym members in this study, we found that 29.2% of participants reported having injuries that were related to the gym with a mean frequency of 2.13 times. Moreover, the main affected body part because of injuries was the shoulder (40.5%), followed by foot (32.4%) and back (25.7%). Among 83 members who indicated having injuries at the gym, 58.1% of them reported visiting a hospital because of the injuries and 11.6% of them reported the need for surgical intervention. Moreover, the incidence of injuries was significantly higher in males than females (53.1%, 19.6%, P = 0.000) and obese participants rather than normal-weight participants (48.4%, 28.9%, P = 0.024). Conclusion: We had developed a validated questionnaire with good reliability to assess the prevalence of gym-related injuries, their causes, and type. Our results showed that the prevalence of injuries among gym members was 29.2%. This prevalence of our study was lower than reported in other studies. However, most of the reported injuries were among males. The most common sites of injury were the shoulder, foot, and back. The most common causes of injury were torsion, severe stress, and iron weights. Moreover, our data confirmed the previous literature that injuries caused by gym exercise could lead to serious consequences that lead to lower quality of life.
The Emerging Role of Dual GLP-1 and GIP Receptor Agonists in Glycemic Management and Cardiovascular Risk Reduction

Abstract The incretin pathway is a self-regulating feedback system connecting the gut with the brain, pancreas, and liver. Its predominant action is on the postprandial glucose levels, with extraglycemic effects on fat metabolism and endovascular function. Of the two main incretin hormones released with food ingestion, the actions of glucagon-like peptide-1 (GLP-1) have been exploited for therapeutic benefit. However, little attention has been paid to glucose-dependent insulinotropic polypeptide (GIP) until the recent experimental introduction of dual agonists, or “twincretins”. Interestingly, simultaneous activation of both receptors is not only replicative of normal physiology, it seems to be an innovative way to enhance their mutual salubrious actions. In patients with type 2 diabetes, dual agonists can have powerful benefits for glucose control and weight reduction. Additionally, there is mounting evidence of their favorable cardiovascular impact, making them potentially appealing pharmacologic agents of choice in the future. Although we seem to be poised on the horizons of exciting new breakthroughs, much knowledge has yet to be gained before these novel agents are ready for prime time.
Price Equations for Understanding the Response of Ecosystem Function to Community Change

The relationship between biodiversity and ecosystem function (BEF) remains unclear in many natural ecosystems, partially for lack of theoretical and analytical tools that match common characteristics of observational community data. The ecological Price equation promises to meet this need by organizing many different species-level changes into a few ecologically meaningful categories that sum to total ecosystem function change. Current versions of the ecological Price equation focus on species richness and presence-absence. However, abundance and relative abundance are better estimated in samples and are likely showing a stronger response to global change. Here, we present a novel, abundance-based version of the ecological Price equation in both discrete and continuous forms and explain the similarities and differences between this method and a related, previously developed richness-based method. We also present new empirical techniques for applying the Price equation to ecological data. Our two demonstration analyses reveal how additive effects of increasing abundance on total function are modified by concurrent selection effects due to shifts in species’ composition as well as intraspecific change in species’ per capita function. The ecological Price equations derived here complement existing approaches and together offer BEF researchers analytical tools and a unifying framework for studying BEF in observational community data.
Recent Evolution in Problems and Methods in Aerodynamics

The Tenth Lanchester Memorial Lecture “Recent Evolution in Problems and Methods in Aerodynamics” was given before the Society on 11th May 1967 by Professor Paul Germain, Director General of ONERA. The Chair was taken by the President, Mr. M. B. Morgan, CB, MA, CEng, FRAeS. Opening the proceedings the President said that they had had a memorable series of lectures in memory of that great man Lanchester and at many of them it had been a great pleasure to have with them his widow, and his brother Mr. George Lanchester and his wife. They were delighted to have them present that evening. They were fortunate to have as their lecturer Professor Germain, a distinguished French Scientist. It was particularly appropriate that their lecturer should come from France when Franco-British aeronautical ties were already close. Professor Germain was well known to the aeronautical research fraternity. Born at St. Malo in 1920, after graduating in Paris he joined ONERA and later became Professor at, first, Poitiers, then Lille and Paris. Since 1962 he had been Director of ONERA. His theoretical work in the transonic and supersonic aerodynamics fields was well known and they also knew him well personally because he had paid numerous visits to research centres in this country. Professor Germain was France’s National delegate to AGARD and Mr. Morgan knew from personal knowledge the intense interest Professor Germain had taken in that international organisation. He held an Honorary Doctorate from Louvain University, was a Correspondent of the Academy of Sciences, Paris, a Fellow of the American Institute of Aeronautics and Astronautics, a Foreign Honorary Member of the American Academy of Arts and Sciences and a member of the International Academy of Astronautics.
Identification and Validation of Dilated Cardiomyopathy-Related Genes via Bioinformatics Analysis

Purpose Dilated cardiomyopathy (DCM) is a type of cardiomyopathy that can easily cause heart failure and has a high mortality rate. Therefore, there is an urgent need to study the underlying mechanism of action of dilated cardiomyopathy. In the present study, we aimed to explore potential miRNA–mRNA pairs and drugs related to DCM. Methods The Microarray data were collected from the Gene Expression Omnibus (GEO) database. Bioinformatics analysis differentially expressed miRNAs and mRNAs in each microarray were obtained. The target genes of miRNAs were obtained from the miRWalk 2.0 database, and the intersection of these two gene sets (miRNA target genes and differentially expressed mRNAs in the microarray) was obtained. Pathway and Gene Ontology (GO) enrichment analyses were performed in the KOBAS database. Cytoscape software was used to construct the miRNA–mRNA network, and the final hub genes were obtained. Furthermore, we predicted several candidate drugs related to hub genes using DSigDB database. To confirm the abnormal expression of hub genes, qRT-PCR was performed. Results In total, eight differentially expressed miRNAs and 92 differentially expressed mRNAs were identified. In addition, 47 differentially expressed miRNA target genes were identified. According to the analysis results of the miRNA-mRNA network, we identified hsa-miR-551b-3p, hsa-miR-770-5p, hsa-miR-363-3p, PIK3R1, DDIT4, and CXCR4 as hub genes in DCM. Several candidate drugs, which are related to the hug genes, were identified. Conclusion In conclusion, in our study, we identified several hub genes that may be involved in the pathogenesis of DCM. Several drugs related to these hub genes may be used as clinical therapeutic candidates.