Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychology for sustainable shared mobility

What are people’s travel patterns – both users and non-users of carsharing and private cars in European cities? What are the main psychological aspects of and motives for making a travel mode choice? This thesis aims to investigate the relationship of habits with attitudinal, normative and motivational aspects to understand the use of private cars and carsharing. Study I presents a classification of motives considered relevant when selecting a mode of transport. It examines the relative importance of driving habits, car attitudes, descriptive norms and motives for transport mode choices for commuting, shopping trips, child-related trips and leisure trips. Socio-demographic variables primarily predicted child-related and commuting trips. Leisure and shopping trips were mainly predicted by driving habits. Driving habit was a common and robust predictor among all trip purposes. In Study II, three mobility styles are identified among the users of carsharing through cluster analysis: a segment that uses different modes of transportation but has low environmental awareness, a segment highly dependent on private car use but that has high environmental awareness and a third segment which also has high environmental awareness and the highest percentage of car-free households. Two mobility styles were identified for the non-users: a segment less favourable to carsharing, with a medium level of environmental awareness and high dependence on private car use, and a segment with the lowest frequency of travel in general and the highest level of environmental awareness. Study III investigates the determinants of intention to use carsharing services using an integrated model of psychological predictors of travel behaviour, with further discussion about the analysis of invariance (configural, metric, scalar) and its relevance for comparisons between groups. The groups were classified as users and non-users of carsharing in Italy and Sweden. The latent variable control was the main predictor of intention to use carsharing, driving habits had stronger negative effects for users of carsharing than for non-users, subjective norms positively predicted the intention to use carsharing among all groups, trust was a predictor of intention only for the Italian groups and climate morality had a small negative effect on only the Swedish groups. Study IV indicates different preferences of carsharing business models depending on the trip purpose, with a trade-off between free-floating (FF) and round-trip stationbased (RTSB) business models. The peer-to-peer (P2P) business model stood out for short holiday trips. Age, educational level, and income affected the probabilities of choosing different carsharing operators. When it comes to driving habits and trust in the service, users of FF and RTSB differ substantially. The results from this thesis can be used as support for governance aiming to promote sustainable transportation by fostering the use of carsharing.
OTT_A_249425 6583..6591

Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University (Henan Cancer Hospital), Zhengzhou, People’s Republic of China Purpose: To investigate the role of the CXCR4/CXCL12 axis in chemotherapy resistance in refractory/relapsed (R/R) ALL patients. Methods: CXCR4 expression on ALL cells from newly diagnosed or R/R ALL patients were detected using flow cytometry. The CXCR4/CXCL12 signaling pathway was blocked by the CXCR4 inhibitor AMD3100 in a co-culture model of primary drug-resistant ALL cells and umbilical cord mesenchymal stem cells (UCMSCs). Surface CXCR4 expression, apoptosis rate, and apoptosis-related protein expression in primary ALL cells under various treatments were detected. Results: Of the 37 ALL patients examined, CXCR4 expression was higher in R/R patients than that in those with newly diagnosed disease. Similarly, in in vitro co-cultures of drugresistant ALL cells with UCMSCs, the expression of CXCR4 was increased in the presence of vincristine (VCR), but reduced when VCR was combined with the CXCR4 antagonist AMD3100. Additionally, the supernatants of ALL-UCMSC co-cultures contained high CXCL12 concentrations, which were upregulated by VCR and significantly decreased by the combination of VCR plus AMD3100. Furthermore, the apoptosis rate of ALL cells significantly decreased, Bax expression was downregulated, and Bcl-2 was upregulated when ALL was co-cultured with UCMSCs compared with ALL cells alone. With the addition of VCR, the apoptosis rate mildly increased, Bax was upregulated, and Bcl-2 was downregulated. Nevertheless, the above results were further intensified, particularly Bax expression, when VCR was combined with AMD3100. Conclusion: The CXCR4 antagonist could effectively reverse MSC-mediated drug resistance by blocking the CXCR4/CXCL12 axis and sensitizing leukemic cells from R/R ALL patients to chemotherapy drugs.
Moore, David R. and Zobay, Oliver and Mackinnon, Robert C. and Whitmer, William M. and Akeroyd, Michael A. (2017) Lifetime leisure music exposure associated with increased frequency of tinnitus. Hearing

Tinnitus has been linked to noise exposure, a common form of which is listening to music as a leisure activity. The relationship between tinnitus and type and duration of music exposure is not well understood. We conducted an internet-based population study that asked participants questions about lifetime music exposure and hearing, and included a hearing test involving speech intelligibility in noise, the High Frequency Digit Triplets Test. 4950 people aged 17e75 years completed all questions and the hearing test. Results were analyzed using multinomial regression models. High exposure to leisure music, hearing difficulty, increasing age and workplace noise exposure were independently associated with increased tinnitus. Three forms of music exposure (pubs/clubs, concerts, personal music players) did not differ in their relationship to tinnitus. More males than females reported tinnitus. The objective measure of speech reception threshold had only a minimal relationship with tinnitus. Self-reported hearing difficulty was more strongly associated with tinnitus, but 76% of people reporting usual or constant tinnitus also reported little or no hearing difficulty. Overall, around 40% of participants of all ages reported never experiencing tinnitus, while 29% reported sometimes, usually or constantly experiencing tinnitus that lasted more than 5 min. Together, the results suggest that tinnitus is much more common than hearing loss, but that there is little association between the two, especially among the younger adults disproportionately sampled in this study. © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
The effect of seed location on functional connectivity: evidence from an image-based meta-analysis

Introduction Default mode network (DMN) is the most involved network in the study of brain development and brain diseases. Resting-state functional connectivity (rsFC) is the most used method to study DMN, but different studies are inconsistent in the selection of seed. To evaluate the effect of different seed selection on rsFC, we conducted an image-based meta-analysis (IBMA). Methods We identified 59 coordinates of seed regions of interest (ROIs) within the default mode network (DMN) from 11 studies (retrieved from Web of Science and Pubmed) to calculate the functional connectivity; then, the uncorrected t maps were obtained from the statistical analyses. The IBMA was performed with the t maps. Results We demonstrate that the overlap of meta-analytic maps across different seeds’ ROIs within DMN is relatively low, which cautions us to be cautious with seeds’ selection. Discussion Future studies using the seed-based functional connectivity method should take the reproducibility of different seeds into account. The choice of seed may significantly affect the connectivity results.
Agro-morphological changes caused by the accumulation of lead in Corchorus olitorius, a leafy vegetable with phytoremediation properties

Lead (Pb) can enter the food chain through the consumption of contaminated plants and can cause serious health issues. However, research on how Pb accumulation affects morphology of leafy vegetables in South Africa is minimal. This study tested the effect of lead accumulation on vegetative and reproductive traits of Corchorus olitorius. Plants were grown under varying Pb concentrations, and studied for their variation in vegetative and reproductive traits as well as Pb accumulation in leaves, stems and roots. Plants grown within allowable soil concentrations of 150 mg kg–1 Pb accumulated toxic (≥ 10 mg kg–1) Pb in all plant parts without causing any morphological defect, except for a decrease in chlorophyll content. Minor reductions in growth and yield were evident only at 900-1000 mg kg–1 concentration. Pb accumulation increased as its concentration increased in the soil, with a higher accumulation in roots in comparison to aerial parts. In conclusion, C. olitorius can grow and reproduce under toxic Pb levels (≥ 300 mg kg–1) and accumulate toxic amounts of Pb (≥ 10 mg kg–1) without visible morphological defects. Therefore, it is suitable for phytoremediation but unsafe for consumption when it is collected from sites prone to Pb contamination.
The use of Tissue Doppler Imaging for the assessment of changes in myocardial structure and function in inherited cardiomyopathies

Although there is still a long way to go, our understanding of the genetic basis of cardiomyopathies e dilated or hypertrophic e has signiﬁcantly improved over the past decade. This new and intriguing era of cardiogenetics has already answered some important questions concerning the pathophysiology of these disorders, but it has also raised some new questions: how do we deﬁne ‘‘presymptomatic’’ mutation carriers? Should we treat them? Do we have any diagnostic tools to identify the presymptomatic subjects in those families where the underlying mutation has not been identiﬁed yet? To address at least part of these questions, there is a clear need for screening techniques in the early stage of the disease which have to be sensitive and non invasive. In recent years Tissue Doppler Imaging (TDI) has emerged as a well suited technique for these purposes and several interesting papers on this issue have been published.Thispaper reviews the ﬁndings from TDI in several forms of inherited cardiomyopathy. Although the implementation of this technique in everyday clinical practice still requires some reﬁnement, the results from these studies are encouraging and TDI is likely to be complementary to other established screening tools such as ECG and conventional echocardiography.
EPIGENETIC MECHANISM OF CANCER: A SHORT REVIEW

Epigenetics can be understood as change in phenotypic characteristics without any change in genotypic structures. It is infact the study of mitotically and/or meiotically heritable changes in the function of the gene which cannot be explained by changes in sequence of DNA. In fact, all cells of a complex multicellular organism contain the same genetic information but during development, each single cell differentiates into a specific phenotype without any changes in DNA sequence. This characteristic of epigenetics implies that the accuracy of epigenetic modifications is crucial for maintaining the genome integrity and the phenotype of the cell. Cancer has been usually thought of as a genetic disease, but it is now known to be an epigenetic disease as well, caused by genetic alterations. Cancer is a disease of various types, they share many traits but each has its own working. Therefore, making it necessary to study the mechanism of action. Epigenetic attributes are reversible, meaning they can be counter-acted upon, giving a chance of curing this disease. Use of decitabine and zebularine for the treatment of blood/bone marrow cancers via epigenetic mechanisms have been FDA approved. This review summarizes the main epigenetic mechanisms of cancer.
Herbal Medicine ( Shakuyaku-kanzo-to ) Improves Olanzapine-Associated Hyperprolactinemia A Case Report

and eating behavior were significantly associated with weight gain during the early phase of antipsychotic treatment. There are some limitations of this study. First, although the 3 index medications used in the current study could cover wide range of antipsychotics’ propensities to induceweight gain, it is hard to generalize the current result to all antipsychotic-related weight gain. Second, we administered the DR-EBQ retrospectively, and some recall bias might have affected the results. Within the aforementioned limitations, the current study’s findings suggest that changes in patients’ eating behavior while taking antipsychotics seem to be highly associated with weight gain and that prominent characteristics of these changes include increased hunger sensation and loss of control over food craving, especially for sweets. Researchers could adopt the eatingbehavior change assessed by the DR-EBQ as a mediating factor in future studies exploring the biological mechanisms of antipsychotic-induced weight gain. Further studies to revise and upgrade the DR-EBQ for use in diverse clinical and biological studies are also warranted.
Comparing Probabilistic Models for Melodic Sequences

Modelling the real world complexity of music is a challenge for machine learning. We address the task of modeling melodic sequences from the same music genre. We perform a comparative analysis of two probabilistic models; a Dirichlet Variable Length Markov Model (Dirichlet-VMM) and a Time Convolutional Restricted Boltzmann Machine (TC-RBM). We show that the TC-RBM learns descriptive music features, such as underlying chords and typical melody transitions and dynamics. We assess the models for future prediction and compare their performance to a VMM, which is the current state of the art in melody generation. We show that both models perform signiﬁcantly better than the VMM, with the Dirichlet-VMM marginally outperforming the TC-RBM. Finally, we evaluate the short order statistics of the models, using the Kullback-Leibler divergence between test sequences and model samples, and show that our proposed methods match the statistics of the music genre signiﬁcantly better than the VMM.
Low Power Bus Encoding Schemes to Minimization of Crosstalk in Vlsi Interconnects

Data integrity is becoming more challenging task as the technology changes scales down in the direction of Deep Sub Micron (DSM) technology. Interconnects architecture design are now measured the bottleneck in the design of Integrated Circuits. In the DSM technology, a coupling capacitance between interconnects is the foremost factor in the total wire capacitance. The combination effect (capacitance formation) dominates the utilization of energy in the run-instant on chip bus. Bus Encoding is the most commonly used technique to change the data pattern before sending data on the bus it reduces the coupling effect on the bus then cuts the power dissipation. The proposed encoding method is the condition based temporal transition data encoding technique, i.e., upper bit inversion, lower bit inversion, upper-lower bit inversion. By using this encoding techniques, it saves the power and reduces the delay.
A Communications-based Mission Planning Tool Concept for Low-cost Tactical UXV Operations

Abstract : New concepts for communications-based tactical decision aids, which can be used for low-costtactical UXV operations, are investigated to provide input for future mission planning tools thatcould be developed for the Royal Canadian Navy. The proposed tactical decision aids provideinformation on where and when communications between a UXV and its base station will beeffective and not effective as a function of the current and future environmental conditions. Therequired signal propagation calculations use data from an Environment Canada numericalweather prediction model and a terrain elevation database. A description is provided of theapproach used to calculate the base quantities (signal-to-noise ratio, , bit error rate) thatare required to form the tactical decisions aids. Example tactical decision aids are calculated fora specific case to demonstrate how this information could be used for planning UXV routes. Theexample case clearly shows regions where communications are effective and not effectivewithin a realistic environment. Experimental trials are required to test the hypothesis that theproposed method is capable of accurately now-casting and forecasting the times and places forwhich a UXV will have effective communication with its base station.
The Impact of the Global Financial Crisis on Real Estate Development Finance in Queensland

Before the Global Financial Crisis many providers of finance had growth mandates and actively pursued development finance deals as a way of gaining higher returns on funds with regular capital turnover and re-investment possible. This was able to be achieved through high gearing and low presales in a strong market. As asset prices fell, loan covenants breached and memories of the 1990‟s returned, banks rapidly adjusted their risk appetite via retraction of gearing and expansion of presale requirements. Early signs of loosening in bank credit policy are emerging, however parties seeking development finance are faced with a severely reduced number of institutions from which to source funding. The few institutions that are lending are filtering out only the best credit risks by way of constrictive credit conditions including: low loan to value ratios, the corresponding requirement to contribute high levels of equity, lack of support in non-prime locations and the requirement for only borrowers with well established track records. In this risk averse and capital constrained environment, the ability of developers to proceed with real estate developments is still being constrained by their inability to obtain project finance. This paper will examine the pre and post GFC development finance environment. It will identify the key lending criteria relevant to real estate development finance and will detail the related changes to credit policies over this period. The associated impact to real estate development projects will be presented, highlighting the significant constraint to supply that the inability to obtain finance poses.
Concolic Testing of Concurrent Software in the Context of Weak Memory Models

With software becoming ubiquitous and increasingly complex, software reliability also becomes more important. Research on software testing and verification tries to create automated solutions which exhaustively search for software bugs. One promising example for these research efforts is concolic testing, a testing technique that combines concrete with symbolic execution and which is implemented in various recent testing tools. However, testing of concurrent software still remains a challenge. One of the main difficulties for testing concurrent software is determining the order in which the statements from different threads have to be executed. The reason for this being a challenge is that the number of possible executions can be intractably big. Furthermore, weak memory models, which describe the memory architectures of modern processors, can further increase the number of possible executions. Weak memory models allow certain deviations from the expected thread-local program order. For example, the effects of a write from one thread to a memory location might not become immediately visible in another thread which reads from this particular memory address. This results from modern memory hierarchies when computations are distributed over several computing cores. The consequence of such behaviours can be software bugs that are hard or even impossible to detect with conventional testing techniques. Most testing tools are based on the assumption of the Sequential Consistency model, i.e., that these effects cannot occur. This thesis presents CONCRESTWMM, a concolic testing tool for concurrent software that is able to simulate the effects of weak memory models during an execution of a program under test. CONCRESTWMM is implemented as an extension of the tool CONCREST, a testing tool for concurrent software. As a central component, CONCRESTWMM adds a WMM-Scheduler. By using WMM-schedules it is possible to select a WMM and to trigger effects of this model at specific points during the execution of a test case. Thus, the tool CONCRESTWMM offers the possibility to discover bugs that can occur on real-world processor architectures that do not adhere to Sequential Consistency but to another WMM. Two WMMs are implemented as part of this thesis. First, the WMM Sequential Consistency which can be used to simulate the behaviour of CONCREST and second, the Partial Store Order (PSO) WMM, a model which allows to delay the effect of a write event. Memory barriers are a common means to limit the deviation of executions from Sequential Consistency. By using memory barriers it is possible to force the effect of writes to become visible. Support for memory barriers is also implemented in CONCRESTWMM. Since many concurrent applications and data structures make use of a Compare and Swap (CAS) operation, a CAS operation is also implemented as part of CONCRESTWMM. The CAS operation updates a memory cell with a new value if the cell contains an expected old value. The built-in operation offers the
and for Secure

This document describes how to specify Ed25519 keys and signatures in DNS Security (DNSSEC). It uses the Edwards-curve Digital Security Algorithm (EdDSA) with the Ed25519 parameter choice. Abstract This document describes how to specify Ed448 keys and signatures in DNS Security (DNSSEC). It uses the Edwards-curve Digital Security Algorithm (EdDSA) with the Ed448 parameter choice. Abstract This document adds recommendations for adoption of ssh-curves from the [I-D.ietf-curdle-ssh-curves], adds some new Modular Exponential (MODP) Groups, and deprecates some previously specified Key Exchange Method algorithm names for the Secure Shell (SSH) protocol. It also updates [RFC4253], [RFC4419], [RFC4462], and [RFC5656] by specifying the set key exchange algorithms that currently exist and which ones MUST, SHOULD, MAY, and SHOULD NOT be implemented. methods use the SHA-2 family of hashes. Abstract This document specifies how the elliptic curve secure remote protocol (EC-SRP) is applied to SIP authentication. SIP Client and server perform mutual authenticate by using the modern ’zero knowledge’ method without disclosing the password in the process. It has low computation complexity and low bandwidth consumption due to the use of elliptical curve cryptography. This makes it more suitable for resource-constrained environments,e.g. wireless network. The security of the scheme is based on the computational intractability of the elliptic curve discrete logarithm problem. It is resilient to various kinds of attacks, including off-line dictionary attacks.
Calculating Product and Customer Sophistication on a Large Transactional Dataset

—The market basket transactions observed at micro-scale (each individual product bought by each individual customer at each store visit) over a large population for a long time, offer a detailed picture of customers’ shopping activity. Given the high cardinality of such a detailed dataset, data mining techniques have been developed to let the hidden knowledge emerge from it. In this technical report, we propose to use the system of all customer-product connections as a whole. We create a framework able to exploit the characteristics of the customer-product matrix and we test it on a unique transaction database, recording the micro-purchases of a million customers observed for several years at the stores of the top national supermarket retailer. We propose it as a novel analytic paradigm for market basket analysis, a paradigm that is challenging both conceptually, given the high complexity of the structures we build, and computationally, given the scale of the data it needs to analyze.