Miracle-dz/UniFAR-FTUs huggingface dataset:
Estimating fibre orientation in spruce using lighting direction

Softwood is almost entirely composed of fibres and its physical properties depend on their orientation. A method is proposed to estimate the average fibre orientation at each pixel in the inspection image. In this study it is shown that finished wood has distinctive reflectance properties that are a consequence of the microstructure of the wood surface. If the fibres lie parallel to the image plane these properties can be used to estimate fibre orientation. It is argued that the reflectance behaviour reported in this study generalises to a wide range of materials with directional microstructures.
Biportal Endoscopic Posterior Thoracic Laminectomy for Thoracic Spondylotic Myelopathy Caused by Ossification of the Ligamentum Flavum: Technical Developments and Outcomes

Objective Advanced biportal endoscopic surgery techniques can be used to treat thoracic myelopathy secondary to ossification of the ligamentum flavum (OLF). This case series elaborates on a feasible biportal endoscopic technique for thoracic OLF removal and evaluates clinical and radiological outcomes. Methods A biportal endoscopic posterior thoracic laminectomy was performed to remove the thoracic OLF. Surgical techniques have evolved from inside-out piecemeal removal methods to outside-in en bloc removal methods. Preoperative computed tomography was performed to analyze dural ossification and OLF types. Intraoperative videos were reviewed to observe dural ossification and to determine the surgical method. Neurological outcomes were assessed using the Japanese Orthopaedic Association (JOA) score. Results Clinical symptoms and neurological function improved markedly after surgery (JOA score, preoperative: 12.6 ± 1.0, final follow-up: 15.6 ± 1.2). The mean operation time per segment was not short (106.6 ± 38 minutes). At early experience stages, inside-out piecemeal decompression was used and it caused intraoperative spinal cord injury. However, outside-in en bloc decompression technique did not induce neural complications. Postoperative segmental instability and correlated mechanical back pain were not observed. Conclusion The biportal endoscopic posterior thoracic approach is an attractive surgical option to treat thoracic spondylotic myelopathy secondary to OLF. Piecemeal inside-out decompression can induce irreversible spinal cord injury, especially in the early experience stages. Outside-in decompression is more efficient and safer than inside-out pattern procedures by minimizing dural manipulation. Nonetheless, this technique is technically demanding and should only be performed in selected patients after acquiring abundant experience with endoscopic spine surgeries.
Structurally Constrained Initial Impedance Modeling for Poststack Seismic Inversion

The establishment of the initial subsurface model is a crucial step for seismic inversion. An accurate and reasonable initial model can mitigate the ill-posedness of seismic inversion and improve the quality of the inversion result. A common method for building an initial model is well-log data interpolation. However, the traditional well-log interpolation method ignores the structural information of the subsurface, resulting in the constructed initial model lacking geological meaning. We propose a novel structurally constrained modeling method (SCMM) to obtain a geologically reasonable initial impedance model for poststack seismic inversion. Well-log interpolation can be represented as an inverse problem. SCMM constrains the inversion process by using a regularization operator that forces the well-log data to be extended to the entire seismic working area along the subsurface local structural direction. First, we calculate the seismic dip from the poststack seismic profile. Then, we design the structural operator based on the estimated seismic dip information to constrain the interpolation process. Under the framework of inversion, the interpolation objective function can be established by combining the structural operator with the well-log data misfit term, and it can be solved efficiently by the conjugate gradient (CG) algorithm. Synthetic and field data tests show that the initial model built by SCMM is more consistent with the geological rules than that built by the traditional method, and the poststack impedance inversion using SCMM is better than that using the traditional modeling method (TMM) in terms of convergence property and accuracy of inversion result.
Effects of Hyperlipidemia on Osseointegration of Dental Implants and Its Strategies

Hyperlipidemia refers to the abnormal increase in plasma lipid level exceeding the normal range. At present, a large number of patients require dental implantation. However, hyperlipidemia affects bone metabolism, promotes bone loss, and inhibits the osseointegration of dental implants through the mutual regulation of adipocytes, osteoblasts, and osteoclasts. This review summarized the effects of hyperlipidemia on dental implants and addressed the potential strategies of dental implants to promote osseointegration in a hyperlipidemic environment and to improve the success rate of dental implants in patients with hyperlipidemia. We summarized topical drug delivery methods to solve the interference of hyperlipidemia in osseointegration, which were local drug injection, implant surface modification and bone-grafting material modification. Statins are the most effective drugs in the treatment of hyperlipidemia, and they also encourage bone formation. Statins have been used in these three methods and have been found to be positive in promoting osseointegration. Directly coating simvastatin on the rough surface of the implant can effectively promote osseointegration of the implant in a hyperlipidemic environment. However, the delivery method of this drug is not efficient. Recently, a variety of efficient methods of simvastatin delivery, such as hydrogels and nanoparticles, have been developed to boost bone formation, but few of them were applied to dental implants. Applicating these drug delivery systems using the three aforementioned ways, according to the mechanical and biological properties of materials, could be promising ways to promote osseointegration under hyperlipidemic conditions. However, more research is needed to confirm.
Golgi-Targeting Anticancer Natural Products

Simple Summary A selected set of natural products that target the structure and function of the Golgi apparatus in cancer cells is highlighted in this review. The potential for modulating these Golgi-mediated signaling pathways for anticancer drug development is also discussed. Abstract The Golgi apparatus plays an important role in maintaining cell homeostasis by serving as a biosynthetic center for glycans, lipids and post-translationally modified proteins and as a sorting center for vesicular transport of proteins to specific destinations. Moreover, it provides a signaling hub that facilitates not only membrane trafficking processes but also cellular response pathways to various types of stresses. Altered signaling at the Golgi apparatus has emerged as a key regulator of tumor growth and survival. Among the small molecules that can specifically perturb or modulate Golgi proteins and organization, natural products with anticancer property have been identified as powerful chemical probes in deciphering Golgi-related pathways and, in particular, recently described Golgi stress response pathways. In this review, we highlight a set of Golgi-targeting natural products that enabled the characterization of the Golgi-mediated signaling events leading to cancer cell death and discuss the potential for selectively exploiting these pathways for the development of novel chemotherapeutic agents.
Estimation of Mouse Carotid Arterial Wall Shear Stress Using High-Frequency Ultrasound Imaging

Wall shear stress (WSS) is a crucial hemodynamic factor that promotes atherosclerosis (plaque) development in arteries; although the relationship between WSS and arterial atherosclerosis has been explored in many animal studies, it is not fully understood. No suitable tool, however, exists for rapidly estimating dynamic WSS in small-animal studies. This study proposes a 40-MHz high-frequency ultrasound (HFUS) imaging system for dynamic WSS estimation based on mouse carotid artery blood flow velocity gradient measurements by vector Doppler imaging (VDI). Aliasing reduces the accuracy of Doppler measurements, which can be prevented by increasing the imaging frame rate. Conventionally, imaging is performed at two tilted angles by alternating between the angles; in the proposed method, the frame rate was doubled by imaging at each tilted angle sequentially and by then temporally aligning the sequences based on pulsatile flow characteristics. Velocity estimation using this method had low errors for both a steady-flow straight-tube and pulsatile flow 60%-stenosis phantom. The method was tested for wild-type (WT) C57BL/6 mice at 16 weeks old and apolipoprotein E knockout (ApoE KO) mice at 16 and 24 weeks old; differences in time-averaged and oscillatory WSS were observed, and histology confirmed that the 24-week ApoE KO mice with the highest oscillatory WSS had the greatest plaque formation. The proposed HFUS WSS imaging method can predict the location and extent of plaque development; thus, this method is useful for small-animal studies investigating the WSS effect on atherosclerotic plaque development.
Communicable Diseases Prevalence among Refugees and Asylum Seekers: Systematic Review and Meta-Analysis

Background: Communicable diseases remain a significant global health issue. The increase in refugees and asylum seekers associated with conflicts may alter the burden of communicable diseases in host countries. We conducted a systematic review of the prevalence of TB, HBC, HCV, and HIV among refugees and asylum seekers by regions of asylum and origin. Methods: Four electronic databases were searched from initiation to the 25 December 2022. Prevalence estimates were pooled into a random-effect model and were stratified by the region of origin and asylum. Meta-analysis was conducted to explore the heterogeneity of the included studies. Results: The most-reported asylum region was The Americas, represented by the United States of America. Asia and the Eastern Mediterranean was the region of the most-reported origin. The highest reported prevalence of active TB and HIV was among African refugees and asylum seekers. The highest reported prevalence of latent TB, HBV and HCV was among Asian and Eastern Mediterranean refugees and asylum seekers. High heterogeneity was found regardless of the communicable disease type or stratification. Conclusion: This review provided insights about refugees’ and asylum seekers’ status around the world and attempted to connect refugees’ and asylum seekers’ distribution and the burden of communicable diseases.
Litter accumulation, not light limitation, drives early plant recruitment

Theory predicts a decline in grassland diversity under nutrient enrichment and loss of herbivory, and one possible cause is hampered seedling recruitment. Two potential drivers for reduced diversity at the seedling level are diminished light availability caused by surrounding vegetation and accumulation of dead biomass. To test the importance of these two mechanisms on early recruitment, we added seeds of 15 herbaceous grassland plant species and monitored sown and natural seedling emergence during one growing season in a full factorial field experiment with light addition and litter removal under fertilization and exclusion of mammalian herbivores in an experimental grassland in Central Germany. We used modern LED lamps, mimicking the spectrum of natural sun light, to provide light to small‐statured understorey plants. This novel experimental set‐up allowed us to specifically disentangle the roles of light limitation and litter accumulation independently and in combination. In general, herbivore exclusion, but not fertilization increased the amount of litter biomass. Litter removal increased seedling number and richness by 83% and 33%, respectively, while light addition had no significant main effect on seedling recruitment, nor did it interact with any other factors, and did not affect recruitment even when litter was removed. In addition, fertilization had a negative and herbivore exclusion a negligible impact on recruitment, and these effects were independent of litter removal. Furthermore, seedling number and richness were unrelated to light intensity and quality, litter depth, soil moisture, temperature and C:N ratio. Synthesis: These results provide novel insights into the role of light limitation versus litter accumulation driving early recruitment and help understanding the mechanisms that affect diversity in grassland communities via recruitment. Our results highlight the detrimental role of litter accumulation as opposed to surrounding vegetation induced light deficiency driving early recruitment from seeds and call for management actions that reduce the amount of litter when maintaining or restoring diversity.
Nanospectrofluorometry inside single living cell by scanning near-field optical microscopy

Near-field fluorescence spectra with subdiffraction limit spatial resolution have been taken in the proximity of mitochondrial membrane inside breast adenocarcinoma cells (MCF7) treated with the fluorescent dye (JC-1) by using a scanning near-field optical microscope coupled with a confocal laser microspectrofluorometer. The probe–sample distance control is based on a piezoelectric bimorph shear force sensor having a static spring constant k=5 μN/nm and a quality factor Q=40 in a physiological medium of viscosity η=1.0 cp. The sensitivity of the force sensor has been tested by imaging a MCF7 cell surface.
One-Pot Phosphonylation of Heteroaromatic Lithium Reagents: The Scope and Limitations of Its Use for the Synthesis of Heteroaromatic Phosphonates

A one-pot lithiation–phosphonylation procedure was elaborated as a method to prepare heteroaromatic phosphonic acids. It relied on the direct lithiation of heteroaromatics followed by phosphonylation with diethyl chlorophosphite and then oxidation with hydrogen peroxide. This protocol provided the desired phosphonates with satisfactory yields. This procedure also had some limitations in its dependence on the accessibility and stability of the lithiated heterocyclic compounds. The same procedure could be applied to phosphonylation of aromatic compounds, which do not undergo direct lithiation and thus require the use of their bromides as substrates. The obtained compounds showed weak antiproliferative activity when tested on three cancer cell lines.
Comparing participation motives of professional and non-professional respondents

In times of declining response rates and over-surveying, improving our understanding of why people participate in surveys is more important than ever. Previous research showed that online panel participants have intrinsic (e.g., topic interest, altruism) and extrinsic (e.g., incentives) participation reasons. Our study expands this research by implementing an experiment using two common forms of survey measurement: ranking and rating. The experiment was fielded in a professional respondents’ sample from a German online panel (n = 407) and in an address-based sample (mail and online) of German non-professional respondents (n = 1,137). Besides extrinsic and intrinsic motivations, the experiment included various study design features (i.e., mode, length, data security) and the mood during the time of contact as possible reasons for participation. The results confirm previous findings regarding the motivations of online panelists but also show important differences between professional and non-professional respondents. Specifically, the main participation reasons of professionals are topic interest (intrinsic) and incentives (extrinsic), while non-professionals are primarily motivated by intrinsic reasons (topic interest and purpose of study). This notion is also supported by the Latent Class Analyses, which showed that three of the four classes for professional respondents had a high probability of naming incentives as one of their main reasons for survey participation, whereas none of the four non-professional clusters rated incentives highly. The differences between the two samples highlight that professional panel members have different motivation structures than participants in general population surveys. This may undermine generalizability, but it also provides opportunities for targeted recruitment.
Rotation of warm nuclei and superdeformation

The Niels Bohr Institute (NBI) has played a leading role in the development of nuclear spectroscopy at high spin and more particularly the study of rotational motion. Indeed, it laid the theoretical foundation stone and contributed to the birth of the workhorse of the field: the Compton-suppressed Ge array. In this article, we will focus, with special emphasis on the contribution of the NBI, on the properties of rotational motion at high excitation energy and on chaotic phenomena associated with nuclear superdeformation.
The Reionization of Cosmic Hydrogen by the First Galaxies

Cosmology is by now a mature experimental science. We are privileged to live at a time when the story of genesis (how the Universe started and developed) can be critically explored by direct observations. Looking deep into the Universe through powerful telescopes, we can see images of the Universe when it was younger because of the finite time it takes light to travel to us from distant sources. Existing data sets include an image of the Universe when it was 0.4 million years old (in the form of the cosmic microwave background), as well as images of individual galaxies when the Universe was older than a billion years. But there is a serious challenge: in between these two epochs was a period when the Universe was dark, stars had not yet formed, and the cosmic microwave background no longer traced the distribution of matter. And this is precisely the most interesting period, when the primordial soup evolved into the rich zoo of objects we now see. The observers are moving ahead along several fronts. The first involves the construction of large infrared telescopes on the ground and in space, that will provide us with new photos of the first galaxies. Current plans include ground-based telescopes which are 24-42 meter in diameter, and NASA’s successor to the Hubble Space Telescope, called the James Webb Space Telescope. In addition, several observational groups around the globe are constructing radio arrays that will be capable of mapping the three-dimensional distribution of cosmic hydrogen in the infant Universe. These arrays are aiming to detect the long-wavelength (redshifted 21-cm) radio emission from hydrogen atoms. The images from these antenna arrays will reveal how the nonuniform distribution of neutral hydrogen evolved with cosmic time and eventually was extinguished by the ultra-violet radiation from the first galaxies. Theoretical research has focused in recent years on predicting the expected signals for the above instruments and motivating these ambitious observational projects.
The Influence of Topography and Lower-Tropospheric Winds on Dryline Morphology

Abstract The effects of topography, wind shear, and zonal wind speed on dryline formation and evolution are investigated using a three-dimensional nonhydrostatic mesoscale model. Rather than conduct a case study a parameter study was performed to examine factors that control the depth and strength of the dryline circulation. This study reveals that the potential for convective storm formation is greatest in those environments in which the cross-dryline flow is weak above the dryline location. This results in boundary layer flow nearly parallel to the north–south-oriented dryline boundary. Under these conditions, the subsiding westerly flow and elevated residual layer formation do not strengthen the capping inversion above the eastern convective boundary layer. In addition, moist air parcels from near the surface are able to reside within the dryline updraft resulting in higher midtropospheric relative humidity subsequently increasing the likelihood of convective storm initiation. As downslope westerly flo.
Formation of the observed double neutron star systems

Abstract We investigate the properties of the immediate progenitors of the double neutron star (DNS) systems detected in the Galactic disc. An analysis of the effect of supernovae on orbital dynamics combined with recent results from the study of hypercritical accretion onto neutron stars shows that the observed systems could not have been formed had the explosion been symmetric. Their formation, however, can be explained if kick velocities are imparted to neutron stars at birth. For this case, we calculate the range of possible DNS progenitors as a function of the kick magnitude and of the time elapsed since the second supernova. For each of the observed systems, we derive a minimum kick magnitude needed for its formation, which, for the close ones, exceeds 200 km s−1.
Enhancing the Anti-Migration Performance and Mechanical Properties of EPDM Insulation through Functionalized GO

The excessive migration of small molecular plasticizers in solid propellants may lead to debonding and changes in combustion characteristics, affecting the safety of solid rocket motors. Herein, two functionalized graphene oxides (GO) were used to enhance the anti-migration performance of EPDM insulation. GO, 3-Aminopropyltriethoxysilane-modified GO (AGO) and octadecylamine-modified GO (HGO) were filled into EPDM to fabricate EPDM insulation. The anti-migration properties and migration kinetics of EPDM insulations were studied using immersion tests. Moreover, the mechanical properties, including the tensile properties, crosslink density, hardness, and aging resistance of different EPDM insulations, were also explored. Compared with GO, AGO, and HGO obviously enhanced the anti-migration and mechanical properties of the EPDM insulations. This study shows that the anti-migration performance of EPDM insulation can be enhanced by functionalized GO.
Astronomy. Herschel will open a new vista on infant stars and galaxies ...

With the biggest mirror yet flown in space, Europe9s new Herschel Space Observatory will peer through a new wavelength window at the cool regions of the universe. It will be launched together with Planck, a mission to map the cosmic microwave background radiation in unprecedented detail (see related story). In addition to studying the formation of galaxies and stars, astronomers hope to use Herschel to study comets, asteroids, and planetary atmospheres in our solar system and how debris disks around stars form into planets.
Impact of N- and Ga-face polarity on the incorporation of deep levels in n-type GaN grown by molecular beam epitaxy

Deep levels in N-face and Ga-face n-type GaN grown by plasma-assisted molecular beam epitaxy were detected, analyzed and compared using deep level optical spectroscopy (DLOS) and conventional thermal deep level transient spectroscopy (DLTS), which together enable deep level detection throughout the GaN band gap. A redistribution of band gap states was observed between the two GaN crystal growth polarities but with a similar total trap density. Most significant was a tenfold concentration increase in a trap at EC-0.25 eV that is likely related to nitrogen vacancies for the N-face polarity material, with no significant change for the Ga-vacancy-related level at EC-2.60 eV. The DLOS results suggest that carbon impurities, which generate several GaN band gap states, appear to incorporate differently for both crystal polarities with the potential carbon interstitial at EC-1.28 eV being undetected for N-face material. Finally, low concentrations of several new levels in the N-face n-GaN not previously observed .