Miracle-dz/UniFAR-FTUs huggingface dataset:
Re-evaluation of NCGR Davis Ficus carica and palmata SSR profiles

To date all public records of F. carica SSR profiles are from NCGR Davis. Prior studies of this data have not been received well because several of the stated relationships do not match what is observed in the field. Upon examination of the prior authors methods it is found that the 1979 Nei similarity measures are not valid distance metrics for the profiles thus invalidating their analysis of genetic distance. Further, the data are tensor in nature and it is shown here that "flattening the data" for use in a vector method will change the problem under study. Consequently the present analysis focuses on geometric, statistical, and biostatistical tensor-based methods–finding that only the latter produces results matching what is manually observed among the profiles. Combining this with historical breeding records and morphologic observations reveals that a modest portion of the profiled accessions are mislabeled–and also reveals the existence of previously undocumented close relations. Another area of concern in the prior studies is the statistical partitioning of the complete graph of distances to define clades. In the present analysis it is shown that genetic clades cannot be defined in this profile collection due to lack of cohesion in nearest neighbor components. It is also shown that it is presently intractable to significantly rectify gaps in the sample population by profile enrichment because the number of individuals in an entire population within the estimated profile distribution exceeds 1014. The profiles themselves are found to have very few occurrences of common values between the 15 loci and thus according to Fisher’s theory of epistatic variance no correlation to phenotype attributes is expected–a result verified by the original investigators. Therefore further discovery of appropriate markers is needed to fully capture geno- and pheno-type characteristics in F. carica and F. palmata SSR profiles.
Bandpass Antenna-Filter-Antenna Arrays for Millimeter-Wave Filtering Applications

This paper introduces new wideband antenna-filter-antenna (AFA) uniform arrays that can be utilized as frequency selective surfaces (FSS) with low loss and sharp roll-off response, which are highly desirable characteristics for millimeter wave applications. The design adopts a simple 3layer single polarization structure consisting of two patch antennas and a resonator. Both simulations and measurements are used to characterize the performances of the proposed design. Overall results show 18.5% 10-dB bandwidth. For the targeted band the insertion loss is less than 0.2 dB. Possible applications include quasi-optical amps, grid mixers and radomes for aircraft radar antennas.
Design and performance analysis of cooperative relay systems

Cooperative relay systems have emerged as promising techniques to boost the performance of wireless systems. Recent studies have confirmed that interferences, co-channel interferences (CCIs) and self-interferences, have a huge impact on cooperative relay systems and can cause significant performance degradation. Two problems were observed in this research. Firstly, previous studies on performance analysis of Amplify-and-Forward (AF) relay systems in presence of CCIs have only focused on a specific interference channel model. However, in practical design scenarios, such an assumption is not a realistic proposition. Secondly, analyses of overheads introduced by a time-based relay selection protocol in distributed cooperative systems have been based on an over-pessimistic assumption where all packets involved in a collision are destroyed. Nevertheless, collisions due to the protocol overheads cause the system performance to be degraded but this does not mean that the failure of end-to-end transmission certainly occurs.The thesis aims to analyse the performance of practical cooperative relay systems in the presence of CCIs and self-interferences, by developing exact mathematical methods. A new unified mathematical method for AF relay systems in presence of a random number of arbitrary non-identical CCIs was developed. The obtained new approach derived in terms of a moment generating function of the aggregate interferences' power led to the derivation of new explicit expressions. The new results greatly simplify evaluation of average error rates over diverse practical interference scenarios. Moreover, a new exact mathematical analysis for distributed cooperative relay systems employing a time-based relay selection protocol based on an accurate interference model was presented. This approach led to the derivation of new exact expressions for the spectral efficiency which accounts for both self-interferences and the protocol overheads as well as for different fading scenarios and arbitrary relay locations. This approach provided several advantages over direct approaches, one of which is that it significantly simplified averaging-out the joint random variables involved.
The Current State of Fat Grafting in the Hand: A Systematic Review for Hand Diseases

Autologous fat grafting (AFG) has traditionally been used for facial rejuvenation and soft tissue augmentation, but in recent years, its use has expanded to treat diseases of the hand. Autologous fat grafting is ideal for use in the hand because it is minimally invasive, can restore volume, and has regenerative capabilities. This review summarizes the emerging evidence regarding the safety and efficacy of AFG to the hand in several conditions, including systemic sclerosis, Dupuytren disease, osteoarthritis, burns, and traumatic fingertip injuries. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses-compliant literature search on the use of AFG in hand pathologies was performed on October 8, 2020, in Ovid MEDLINE, Elsevier Embase, Clarivate Web of Science, and Wiley Cochrane Central Register of Controlled Trials. The retrieved hits were screened and reviewed by 2 independent reviewers and a third reviewer adjudicated when required. Reviewers identified 919 unique hits. Screening of the abstracts identified 22 manuscripts which described the use of AFG to treat an identified hand condition. Studies suggest AFG in the hands is a safe, noninvasive option for the management of systemic sclerosis, Dupuytren contracture, osteoarthritis, burns, and traumatic fingertip injuries. While AFG is a promising therapeutic option for autoimmune, inflammatory, and fibrotic disease manifestations in the hand, further studies are warranted to understand its efficacy and to establish more robust clinical guidelines. Studies to date show the regenerative, immunomodulatory, and volume-filling properties of AFG that facilitate wound healing and restoration of hand function with limited complications.
Potentials of Online Media and Location-Based Big Data for Urban Transit Networks in Developing Countries

Big data, collected in the form of social media posts and mobile phone location tracking, have great potential to inform and manage the planning and operation of transit networks in developing countries. Data are widely available, but the challenge, as with developed countries, is figuring out how best to use it. A case study method was used to consider approaches in Nairobi, Kenya; Istanbul, Turkey; and Dhaka, Bangladesh. In Nairobi, GPS location data were collected to generate the first map of the complex Matatu transit network. In Istanbul, automated fare collection systems were processed to understand better the usage of a bus rapid transit system. In Dhaka, researchers were collecting GPS positioning data to manage the city bus networks. Residents of these developing cities were frequent users of online media, as in many cities in the developing countries. This study revealed that integration of online media with location-based data provided a big data scenario that had the potential for supporting transit operations while posing challenges to the management of data mobility. It is not realistic to apply a one-size-fits-all approach to any problem in the developing world, but together the case studies show that with the right approach, technical capacity in transitional cities has the potential to grow to support higher-level data processing and make more efficient and more sustainable policy decisions for crucial urban transit networks in developing countries.
Estimation of production and revenue development in granite artisanal and small scale mining using Markovian model

In this study, an algorithm is proposed for estimating revenue development for artisanal and small scale granite mining based on information of respective gender coefficients of involvement, respective gender granite cracking rates per day, Markovian dynamic programming concept, and standardization cost and criteria. This is particularly important because of a need to evaluate artisanal and small scale mining for standardization and control of practice in terms of gender involvement, environmental health, safety, and job creation. The results show that estimated cost of standardization for granite artisanal and small scale mining in Southwest Nigeria is approximately 10 million naira and that revenue development, exhibiting the Markovian property and criteria, can be expressed as a probabilistic dynamic programming model for forecasting revenue development and expected period it will take an artisanal and small scale mine to reach a cumulative revenue that can cover required costs for standardization of operations.
Effects of the WRITE Symptoms Interventions on Symptoms and Quality of Life Among Patients With Recurrent Ovarian Cancers: An NRG Oncology/GOG Study (GOG-0259)

PURPOSE GOG-259 was a 3-arm randomized controlled trial of two web-based symptom management interventions for patients with recurrent ovarian cancer. Primary aims were to compare the efficacy of the nurse-guided (Nurse-WRITE) and self-directed (SD-WRITE) interventions to Enhanced Usual Care (EUC) in improving symptoms (burden and controllability) and quality of life (QOL). METHODS Patients with recurrent or persistent ovarian, fallopian, or primary peritoneal cancer with 3+ symptoms were eligible for the study. Participants completed baseline (BL) surveys (symptom burden and controllability and QOL) before random assignment. WRITE interventions lasted 8 weeks to develop symptom management plans for three target symptoms. All women received EUC: monthly online symptom assessment with provider reports; online resources; and every 2-week e-mails. Outcomes were evaluated at 8 and 12 weeks after BL. Repeated-measures modeling with linear contrasts evaluated group by time effects on symptom burden, controllability, and QOL, controlling for key covariates. RESULTS Participants (N = 497) reported mean age of 59.3 ± 9.2 years. At BL, 84% were receiving chemotherapy and reported a mean of 14.2 ± 4.9 concurrent symptoms, most commonly fatigue, constipation, and peripheral neuropathy. Symptom burden and QOL improved significantly over time (P < .001) for all three groups. A group by time interaction (P < .001) for symptom controllability was noted whereby both WRITE intervention groups had similar improvements from BL to 8 and 12 weeks, whereas EUC did not improve over time. CONCLUSION Both WRITE Intervention groups showed significantly greater improvements in symptom controllability from BL to 8 and BL to 12 weeks compared with EUC. There were no significant differences between Nurse-WRITE and SD-WRITE. SD-WRITE has potential as a scalable intervention for a future implementation study. Both nurse- and self-directed WRITE Symptoms improved symptom controllability in recurrent ovarian cancer
Plant immunity: Rice XA21-mediated resistance to bacterial infection

Significance The mechanisms plants employ to resist infection were unknown until just a few decades ago. We now understand that plants utilize diverse classes of immune receptors to recognize and respond to pathogenic microbes and pests. This paper describes the development of the plant immunity field, from early studies on the genetics of disease resistance to our increasing knowledge of how plant receptors interact with their microbial ligands, with an emphasis on the rice immune receptor XA21 and its bacterial ligand. In this article, we describe the development of the plant immunity field, starting with efforts to understand the genetic basis for disease resistance, which ∼30 y ago led to the discovery of diverse classes of immune receptors that recognize and respond to infectious microbes. We focus on knowledge gained from studies of the rice XA21 immune receptor that recognizes RaxX (required for activation of XA21 mediated immunity X), a sulfated microbial peptide secreted by the gram-negative bacterium Xanthomonas oryzae pv. oryzae. XA21 is representative of a large class of plant and animal immune receptors that recognize and respond to conserved microbial molecules. We highlight the complexity of this large class of receptors in plants, discuss a possible role for RaxX in Xanthomonas biology, and draw attention to the important role of sulfotyrosine in mediating receptor–ligand interactions.
The Effects of ACMI Flight Crew’s Long Term Outstation Hotel Stay on Accumulated Fatigue

Abstract ACMI flight crews spend considerable time away from home on outstations. This manuscript suggests that long term stay carries its own considerations in regards to rest recovery with practical implications for Fatigue Risk Management. Four recovery factors are identified and are to be correlated with 28 crew behaviors. The end result might indicate improvement considerations for airline management organizing a long term contract with ACMI crews.
Application of Magnetic Resonance Imaging in Neoadjuvant Treatment of Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignant tumors of the human digestive system. Due to its insidious onset, many patients have already lost the opportunity for radical resection upon tumor diagnosis. In recent years, neoadjuvant treatment for patients with borderline resectable PDAC has been recommended by multiple guidelines to increase the resection rate of radical surgery and improve the postoperative survival. However, further developments are required to accurately assess the tumor response to neoadjuvant therapy and to select the population suitable for such treatment. Reductions in drug toxicity and the number of neoadjuvant cycles are also critical. At present, the clinical evaluation of neoadjuvant treatment is mainly based on several serological and imaging indicators; however, the unique characteristics of PDAC and the insufficient sensitivity and specificity of the markers render this system ineffective. The imaging evaluation system, magnetic resonance imaging (MRI), has its own unique imaging advantages compared with computed tomography (CT) and other imaging examinations. One key advantage is the ability to reflect the changes more rapidly in tumor tissue components, such as the degree of fibrosis, microvessel density, and tissue hypoxia. It can also perform multiparameter quantitative analysis of tumor tissue and changes, attributing to its increasingly important role in imaging evaluation, and potentially the evaluation of neoadjuvant treatment of pancreatic cancer, as several current articles have studied. At the same time, owing to the complexity of MRI and some of its limitations, its wider application is limited. Compared with CT imaging, few relevant studies have been conducted. In this review article, we will investigate and summarize the advantages, limitations, and future development of MRI in the evaluation of neoadjuvant treatment of PDAC.
Clinical Practice Patterns With Pediatric Loudness Perception Measures.

PURPOSE Obtaining a patient's loudness discomfort level (LDL) can assist the audiologist in defining their dynamic range so that the hearing device fitting can ensure that low-level sounds are audible, average-level sounds are comfortable, and more intense sounds are loud but not too loud. A 2016 survey showed that 67.5% of 350 pediatric audiologist reported to never or rarely measure LDLs with pediatric patients. The purpose of this study was to identify factors influencing this previously reported limited use of LDL measures. METHOD Sixty-two pediatric audiologists in the United States were surveyed using a questionnaire that sought to improve our understanding of the (non)use of loudness perception measures with pediatric patients and to assess familiarity with various loudness perception measurements. In addition, the questionnaire gathered information about the needs of pediatric audiologists in relation to LDL measures. RESULTS Audiologist report being largely unfamiliar with methods of assessing loudness perception in children, with categorical loudness scaling being the method with which they are most familiar. In addition, audiologists reported being more willing and able to measure LDLs in older compared to younger pediatric patients. Limited use of pediatric loudness perception measures appears to be driven by a lack of familiarity with measurement methods and the belief that loudness perception measures may not be useful for clinical practice. CONCLUSIONS Findings highlight audiologists' need for further information regarding the relevance of loudness perception measurements with pediatric patients and the need for easy-to-implement LDL measurement procedures for pediatric patients of all ages.
Antegrade Instillation of UGN-101 (Mitomycin for Pyelocalyceal Solution) for Low-Grade Upper Tract Urothelial Carcinoma: Initial Clinical Experience

Purpose: UGN-101 (mitomycin for pyelocalyceal solution) is a recently approved chemoablative treatment for low-grade (LG) upper tract urothelial carcinoma (UTUC). While approved for retrograde or antegrade administration, previous reports discuss only patients treated by retrograde approach. We report our techniques for antegrade administration along with early outcomes from our cohort of patients who have undergone UGN-101 administration via nephrostomy. Materials and Methods: UGN-101 is administered as 6 weekly instillations in patients who have undergone endoscopic ablation of LG UTUC. We outline our approach in patients thought to have LG UTUC from initial ureteroscopy to nephrostomy placement, UGN-101 administration and eventual nephrostomy removal. We discuss early durability of response along with adverse events with special attention to ureteral strictures. Results: Eight patients underwent antegrade UGN-101 administration during the study period, all of whom underwent followup ureteroscopy with complete response in 4 patients. Three patients reported 5 adverse events—3 grade 1, 1 grade 2 requiring 1 week delay of treatment and 1 asymptomatic ureteral stricture. Median followup was 7 months. Conclusions: We outline our approach for antegrade administration of UGN-101 and discuss early results along with adverse events. Future studies should evaluate our method’s potential to increase patient comfort, improve logistics and decrease risk of adverse events.
Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, the current status and potential of SCL development through a comprehensive review from fabrication to applications to commercialization are discussed. First, the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications are discussed. Then, the latest advances in diagnostic and therapeutic SCLs for clinical translation are reviewed. Later, the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices are summarized. An outlook, future opportunities, and challenges for developing next‐generation SCL devices are also provided. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.
Glucocorticoid receptors participate in epilepsy in FCDII patients and MP model rats: A potential therapeutic target for epilepsy in patients with focal cortical dysplasia II (FCDII)

ABSTRACT Background Glucocorticoid receptors (GRs) and mineralocorticoid receptors (MRs) are involved in neuronal excitability, neurogenesis, and neuroinflammation. However, the roles of GRs and MRs in epilepsy in focal cortical dysplasia II (FCDII) have not been reported. Research Design and Methods We evaluated GRs and MRs expression and distribution in FCDII patients and methylazoxymethanol-pilocarpine-induced epilepsy model rats (MP rats), and the effects of a GR agonist on neurons in human FCDII and investigated the electrophysiological properties of rats’ neurons after lentivirus-mediated GR knockdown or overexpression and GR agonist or antagonist administration. Results GR expression (not MR) was decreased in specimens from FCDII patients and model rats. GR agonist dexamethasone reduced neuronal excitatory transmission and increased neuronal inhibitory transmission in FCDII. GR knockdown increased the excitability of cultured neurons, and GR overexpression rescued the hyperexcitability of MP-treated neurons. Moreover, dexamethasone decreased neuronal excitability and excitatory transmission in MP rats, while GR antagonist exerted the opposite effects. Dexamethasone reduced the seizure number and duration by approximately 85% and 60% in MP rats within one to two hours. Conclusions These results suggested that GRs play an important role in epilepsy in FCDII and GR activation may have protective and antiepileptic effects in FCDII.
Time to blur the blast boundaries

As prognostic classification systems for myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are further refined with the incorporation of cytogenetic and molecular data, 3 it is becoming increasingly challenging to submit to a 20% bone marrow blast cutoff to arbitrarily distinguish MDS from AML. This is particularly relevant as available treatments for patients with MDS and AML continue to expand, with often markedly different regimens recommended to a patient according to the semantics of the MDS definition versus the AML definition. Take, for example, the case of a healthy 57yearold female patient with “MDS” who has 18% blasts, diploid cytogenetics, and an NPM1 mutation. If this case were considered strictly as highrisk MDS, she would most likely be recommended to receive a hypomethylating agent (HMA) alone instead of an intensive chemotherapy (IC) approach despite the known chemosensitivity of NPM1 mutations (even in the presence of underlying multilineage dysplasia) and her age and performance status, which would clearly advocate for IC had this been alternatively diagnosed as AML. 6