Miracle-dz/UniFAR-FTUs huggingface dataset:
Weighted gene co-expression network analysis identifies key hub genes and pathways in acute myeloid leukemia

Introduction: Acute myeloid leukemia (AML) is the most common type of leukemia in adults. However, there is a gap in understanding the molecular basis of the disease, partly because key genes associated with AML have not been extensively explored. In the current study, we aimed to identify genes that have strong association with AML based on a cross-species integrative approach. Methods: We used Weighted Gene Co-Expression Network Analysis (WGCNA) to identify co-expressed gene modules significantly correlated with human AML, and further selected the genes exhibiting a significant difference in expression between AML and healthy mouse. Protein-protein interactions, transcription factors, gene function, genetic regulation, and coding sequence variants were integrated to identify key hub genes in AML. Results: The cross-species approach identified a total of 412 genes associated with both human and mouse AML. Enrichment analysis confirmed an association of these genes with hematopoietic and immune-related functions, phenotypes, processes, and pathways. Further, the integrated analysis approach identified a set of important module genes including Nfe2, Trim27, Mef2c, Ets1, Tal1, Foxo1, and Gata1 in AML. Six of these genes (except ETS1) showed significant differential expression between human AML and healthy samples in an independent microarray dataset. All of these genes are known to be involved in immune/hematopoietic functions, and in transcriptional regulation. In addition, Nfe2, Trim27, Mef2c, and Ets1 harbor coding sequence variants, whereas Nfe2 and Trim27 are cis-regulated, making them attractive candidates for validation. Furthermore, subtype-specific analysis of the hub genes in human AML indicated high expression of NFE2 across all the subtypes (M0 through M7) and enriched expression of ETS1, LEF1, GATA1, and TAL1 in M6 and M7 subtypes. A significant correlation between methylation status and expression level was observed for most of these genes in AML patients. Conclusion: Findings from the current study highlight the importance of our cross-species approach in the identification of multiple key candidate genes in AML, which can be further studied to explore their detailed role in leukemia/AML.
ASSESS THE IMPACT OF CHILDHOOD NUTRITIONAL STATUS: A CASE STUDY OF DISTRICT KOHLU BALOCHISTAN

In order to assess the impact of childhood nutritional status this research was carried out in district Kohlu Balochistan. Cross-sectional study was carried out. 700 sample sizes were selected among them 313 were males and 387 females respectively. Field survey technique was used. Raw information was thus coded, edited, and installed into SPSS version 22.0. Descriptive analysis was used. Results show that more than half (56%) of the children were female. Majority (70%) of the children belonged from 6-24 months. While, most 30% of the children belonged from 25-59 months. Most 15% of fathers and (49%) of mothers were illiterate. While, 42% of fathers and (33%) of mothers have a primary level of education. Fraction numbers 11% of fathers and only (3%) of mothers hold a high level of education at a formal institution. Majority (65%) of the children having poorer appetite status. More than half (57%) of the children did not lose their body weight. Majority (67%) of the children having chronic diseases at district level. Vast majority (90%) of the children vaccinated at district level. Based on achieved outcomes this research recommended that both public and private sectors related with nutrition management should start the Effective Nutrition Program at district level for children. Beneficial health facilities should be provided at tehsil level.
Effect of Postoperative Non-Weight-Bearing in Trochanteric Fracture of the Femur: A Retrospective Cohort Study Using Propensity Score Matching

Introduction The effects of postoperative early weight-bearing (WB) on walking ability, muscle mass, and sarcopenia have been investigated. Postoperative WB restriction is also reportedly associated with pneumonia and prolonged hospitalization; however, its effect on surgical failures has not been studied. This study aimed to assess whether WB restriction after surgery for trochanteric fracture of the femur (TFF) is useful in preventing surgical failure, considering the unstable fracture type, quality of intraoperative reduction, and tip-apex distance. Patients and Methods This retrospective analysis included 301 patients admitted to a single institution between January 2010 and December 2021, diagnosed with TFF, and who underwent femoral nail surgery. Eight patients were excluded, and finally 293 patients were included in the study. Propensity score (PS) matching yielded 123 cases; 41 patients in the non-WB (NWB) group and 82 patients in the WB group were included in the final analysis. The primary outcome was surgical failure (cutout, nonunion, osteonecrosis, and implant failure). The secondary outcomes were medical complications (pneumonia, urinary tract infection, stroke, and heart failure), change in walking ability, period of hospitalization, and sliding distance of the lag screw. Results Five surgical complications occurred in the NWB group and two in the WB group, with significantly more surgical complications in the NWB group (P = .041). Cutout occurred in two cases, each in the NWB and WB groups. Two cases of nonunion and one case of implant failure occurred in the NWB group, but not in the WB group. Osteonecrosis did not occur in both groups. The secondary outcomes were not significantly different between the two groups. Conclusions The results of this retrospective cohort study using a PS matching approach showed that WB restriction after TFF surgery could not decrease the incidence of surgical failures.
The Load-Modulated Linearizer: A Technique for Intermodulation Cancellation in PA Systems

A novel application utilizing the load-modulated balanced amplifier (LMBA) principle to actively absorb individual out-of-band intermodulation distortion (IMD) components at the output of a power amplifier operating in high compression is presented. The system is able to correct AM/AM distortion by absorbing the unwanted IMD components using active load-modulation. We achieve IMD suppression of about 30dB, while the main PA operates at the P3dB compression point and above, with a phase and amplitude error tolerance of ±2 degrees and ±0.5 dB, respectively. It retains the power conservation properties of the LMBA and achieves linearization at a very low power and complexity penalty.
Effect of wall boundary condition on scalar transfer in a fully developed turbulent flume

We performed direct numerical simulation of fully developed turbulent velocity and temperature fields in a flume, for Reynolds number, based on the wall shear velocity and the height of the flume, Re=171 and Prandtl numbers Pr=1.0 and Pr=5.4. To elucidate exactly the role of the wall boundary condition for passive scalar, the system considered was the flow at constant properties of the fluid. Two types of thermal wall boundary conditions (BCs) for the dimensionless temperature equation were studied: isothermal wall boundary condition—H1, and isoflux wall boundary condition—H2. The profile of the mean temperature was not affected by the type of BC. However, the type of BC has a profound effect on the statistics of the temperature fluctuations in the near-wall region y+<10. Comparison of near-wall statistics of temperature fluctuations shows that at Pr=1 the buffer part of the turbulent boundary layer significantly influences the scalar transfer in the conductive sublayer, whereas at Pr=5.4 the near-wall te.
Estimation of dependence between paired correlated failure times in the presence of covariate measurement error

Summary. In many biomedical studies, covariates are subject to measurement error. Although it is well known that the regression coefficients estimators can be substantially biased if the measurement error is not accommodated, there has been little study of the effect of covariate measurement error on the estimation of the dependence between bivariate failure times. We show that the dependence parameter estimator in the Clayton–Oakes model can be considerably biased if the measurement error in the covariate is not accommodated. In contrast with the typical bias towards the null for marginal regression coefficients, the dependence parameter can be biased in either direction. We introduce a bias reduction technique for the bivariate survival function in copula models while assuming an additive measurement error model and replicated measurement for the covariates, and we study the large and small sample properties of the dependence parameter estimator proposed.
Non-exotic traversable wormhole solutions in linear f ( R , T ) gravity

In this work we analyze traversable wormhole solutions in the linear form of f ( R , T ) = R + λ T gravity satisfying the Null, Weak, Strong, and Dominant Energy Conditions (NEC, WEC, SEC, and DEC respectively) for the entire spacetime. These solutions are obtained via a fully analytical parameter space analysis of the free parameters of the wormhole model, namely the exponents controlling the degree of the redshift and shape functions, the radius of the wormhole throat r 0 , the value of the redshift function at the throat ζ 0 , and the coupling parameter λ . Bounds on these free parameters for which the energy conditions are satisﬁed for the entire spacetime are deduced and two explicit solutions are provided. Even if some of these bounds are violated, leading to the violation of the NEC at some critical radius r c > r 0 , it is still possible to ﬁnd physically relevant wormhole solutions via a matching with an exterior vacuum spacetime in the region where the energy conditions are still satisﬁed. For this purpose, we deduce the set of junction conditions for the form of f ( R , T ) considered and provide an explicit example. These results seem to indicate that a wide variety of non-exotic wormhole solutions are attainable in the f ( R , T ) theory without the requirement of ﬁne-tuning.
Bandgap and optical absorption edge of GaAs1−xBix alloys with 0 < x < 17.8%

The compositional dependence of the fundamental bandgap of pseudomorphic GaAs1−xBix layers on GaAs substrates is studied at room temperature by optical transmission and photoluminescence spectroscopies. All GaAs1−xBix films (0 ≤ x ≤ 17.8%) show direct optical bandgaps, which decrease with increasing Bi content, closely following density functional theory predictions. The smallest measured bandgap is 0.52 eV (∼2.4 μm) at 17.8% Bi. Extrapolating a fit to the data, the GaAs1−xBix bandgap is predicted to reach 0 eV at 35% Bi. Below the GaAs1−xBix bandgap, exponential absorption band tails are observed with Urbach energies 3–6 times larger than that of bulk GaAs. The Urbach parameter increases with Bi content up to 5.5% Bi, and remains constant at higher concentrations. The lattice constant and Bi content of GaAs1−xBix layers (0 < x ≤ 19.4%) are studied using high resolution x-ray diffraction and Rutherford backscattering spectroscopy. The relaxed lattice constant of hypothetical zincblende GaBi is estimated t.
A back‐tracking procedure for optimization of simplex meshes

SUMMARY This work presents a back-tracking procedure for the optimization of meshes. It can be applied to all ill-shaped elements in a mesh in order to improve quality in mesh optimization. Basically, the original mesh is reconstructed in regions around the ill-shaped elements by means of a set of deletion and reconstruction operations based on visibility tests. The back-tracking procedurexes problems related to the quality of generated meshes in general and can be applied in two or three dimensions. The procedure works by deleting elements ranked below a predened shape quality measure. It is important to mention that, although the presented procedure was devised for advancing-front algorithms, it can also be used in meshes generated by dierent approaches, such as Delaunay and others, requiring no modication. The proposed procedure is applicable to simplex elements (triangles and tetrahedra), although ideally it could be extended to other types of elements. Examples of improved meshes using the back-tracking procedure are presented, in which the quality of these meshes is assessed in order to validate the procedure proposed in this work. Copyright ? 2005 John Wiley & Sons, Ltd.
Simplification of the Lyapunov matrix equation A_{T}PA - P = -Q

It is shown that in solving for the symmetric matrix P the number of linear equations and unknowns can be reduced from \frac{1}{2}n(n + 1) to \frac{1}{2}n(n - 1) by introducing a skew-symmetric matrix. This corresponds to an earlier result for the equation A_{1}^{T}P_{1} + P_{1}A = -Q .
Neural network-based compensation control of mobile robots with partially known structure

This study proposes an inverse non-linear controller combined with an adaptive neural network proportional integral (PI) sliding mode using an on-line learning algorithm. The neural network acts as a compensator for a conventional inverse controller in order to improve the control performance when the system is affected by variations on their dynamics and kinematics. Also, the proposed controller can reduce the steady-state error of a non-linear inverse controller using the on-line adaptive technique based on Lyapunov's theory. Experimental results show that the proposed method is effective in controlling dynamic systems with unexpected large uncertainties.
The black hole–bulge relation in active galactic nuclei

We have used the widths of Hβ and [O III] emission lines to investigate the black hole-bulge relation in radio-loud active galactic nuclei (AGNs), radio-quiet AGNs and narrow-line Seyfert I galaxies (NLS1s). The central black hole mass, M bh , is estimated from the Hβ linewidth and the optical luminosity, and the bulge velocity dispersion, a, is directly estimated from the width of the [O III] line. We have found that radio-quiet AGNs follow the established M bh -σ relationship in nearby inactive galaxies, while radio-loud AGNs and NLS1s deviate from this relationship. There are two plausible interpretations for the deviation of radio-loud AGNs. One is that the size of broad-line regions (BLRs) emitting the HAS line is overestimated because of the overestimation of optical luminosity. The other is that the dynamics of BLRs and/or narrow-line regions in radio-loud AGNs is different from that in radio-quiet AGNs. The deviation of NLS1s may be due to the small inclination of BLRs to the line of sight or the reliability of the [O III] linewidth as the indicator of stellar velocity dispersion because of its complex multiple components.
Cognitive trends in an urban Indian elderly community: Glycated hemoglobin and geriatric depression play a bigger role than age

Abstract Objectives: To explore the cognitive profile in urban Indian older adults and observe the prevalence of cognitive impairment associated with age, glycated hemoglobin (HbA1c) levels, vitamin B12, and other psychosocial factors Methods: Urban community dwelling older adults (55 to 85years, n=123) underwent a detailed demographic and cognitive assessment comprising of tests from different cognitive domains (memory, executive function, visuospatial abilities, and verbal fluency). Serum samples were collected from a subset of participants (n=60) to determine HbA1c and vitamin B12 levels. Results: Performance in all cognitive domains declined with age. The decline became prominent around age 70. HbA1c correlated inversely with processing speed and executive function. Vitamin B12 did not correlate with performance on any cognitive test. Geriatric depression correlated inversely with visuospatial abilities. Surprisingly, stepwise multiple regression revealed that HbA1c and geriatric depression contributed to 28% variance on Montreal Cognitive Assessment whereas participant age did not contribute significantly. Mild Cognitive Impairment (MCI) was observed in 17% of participants. Participants classified as MCI had higher levels of HbA1c and geriatric depression, and lower performance in all cognitive domains compared to non MCI participants. Conclusion: Although cognitive performance declined with age, HbA1c and geriatric depression played a greater role than age in predicting cognitive decline. This study highlights the prevalence of metabolism linked changes in cognition in community dwelling Indian older adults.
Impact of Synchronized Left Ventricular Pacing in Cardiac Resynchronization Therapy

Background: The adaptive cardiac resynchronization therapy (aCRT) algorithm enables synchronized left ventricular pacing (sLVP) to produce fusion with intrinsic right ventricular activation in normal atrioventricular (AV) conduction. Although sLVP presents benefits over biventricular pacing (BVP), the adequate sLVP rate for better clinical outcomes remains unclear. This study aimed to assess the association between sLVP rates and clinical outcomes. Methods: Among our cohort of 271 consecutive patients who underwent CRT implantation between April 2016 and August 2021, we evaluated 63 patients who underwent CRT without considerably prolonged AV conduction and applied the aCRT algorithm (48 men, mean age: 64 {+/-} 14 years; median follow-up period: 316 days [interquartile range: 212-809 days]). Results: At the 6-month follow-up after CRT implantation, the frequency of CRT responders was 71% (n = 45). The sLVP rate was significantly higher in responders than in non-responders (75 {+/-} 30 vs. 47 {+/-} 40 %, p = 0.003). Receiver operating characteristics (ROC) curve analysis revealed that the optimal cut-off value during the sLVP rate was 59.4% for prediction of CRT responders (area under the curve, 0.70; sensitivity, 80%; specificity, 61%; positive predictive value, 84%; and negative predictive value, 55%). Kaplan-Meier analysis demonstrated that the higher sLVP group (sLVP {greater than or equal to}59.4%, n = 43) had better prognosis (cardiac death and heart failure hospitalization) than the lower sLVP group (sLVP <59.4%, n = 20) (log-rank p<0.001), and multivariate Cox hazard analysis revealed that a higher sLVP rate was associated with good prognosis (p<0.001). Conclusion: sLVP was associated with CRT response, and higher sLVP rate ([≥] 59.4%) is important for good prognosis in patients with aCRT.
Association of select psychiatric disorders with incident brain aneurysm and subarachnoid hemorrhage among veterans

Background: Brain aneurysms represent a significant cause of hemorrhagic stroke. Prior research has demonstrated links between stress and stroke, including brain aneurysms. We aimed to determine relationships between select psychiatric disorders and aneurysms and aneurysmal SAH. Methods: We performed retrospective, case-control study of a National Veterans Affairs population with two experimental groups (aneurysm-only and aneurysmal SAH) and 10-fold controls per group matched by age, date, and clinical data source. The studied the presence of 4 psychiatric disorders: Posttraumatic stress disorder (PTSD), major depressive disorder (MDD), generalized anxiety disorder (GAD), and other mood disorders. Our main outcomes Unadjusted and multivariable adjusted ORs of PTSD, MDD, GAD, and mood disorders within aneurysm-only and aSAH groups. Results: In 6,320,789 US Veterans who were enrolled for at least 5 years in Medicare and/or the Veterans Health Administration, we identified 35,094 cases of aneurysm without SAH and 5749 cases of aneurysm with SAH between 1/2005 and 12/2019. In analyses adjusted for sex, hypertension, and tobacco use, patients with aneurysm were more likely than matched controls to have a history of PTSD (OR 1.48), MDD (OR 1.33), GAD (OR 1.26), and other mood disorders (OR 1.34) (all p values <0.0001). Similarly, patients with aSAH were more likely than controls to have a history of PTSD (OR 1.35), MDD (OR 1.38), GAD (OR 1.18), and other mood disorders (OR 1.30) (all p values <0.0001). Conclusions: The study, the largest of its kind, further suggests links between psychiatric disorders and stroke. This is important as patients with aneurysms are not routinely screened for such psychiatric risk factors. Additional research on this topic could lead to novel strategies to improve stroke prevention.
The impact of Short Tandem Repeats on grey matter brain imaging derived phenotypes in UK Biobank

We performed a genome-wide association study of 143,067 highly polymorphic short tandem repeats (STRs) with MRI brain grey matter volumes (GMVs) on 10,702 UK Biobank (UKB) participants, including 8,751 in the discovery stage and 1,701 in the replication analysis. STRs' repeat lengths were estimated from the UKB whole-genome sequencing data using Expansion Hunter software. A total of 262 STRs reached genome-wide significance in the analyses of the autosomal and sex chromosomes' (P = 6.9 x 10-8) in association with MRI-GMVs. Replication in a second batch extraction in the UKB and linkage disequilibrium (LD) analyses confirmed 12 associations of five STRs with hippocampal, intra-calcarine cortex, and cerebellum volumes with no evidence of single nucleotide polymorphisms (SNP) in LD detected in the surrounding DNA regions. Our study highlights the importance of STR variants involved in the genetic architecture of grey matter volumes.
An assessment of rates and covariates of mpox diagnosis and vaccination provides evidence to refine eligibility criteria for mpox vaccination among gay, bisexual and other men who have sex with men in the Netherlands

Background: The 2022 multicountry mpox outbreaks predominantly affected gay, bisexual and other men who have sex with men (GBMSM) in non-endemic countries. Mpox vaccination is most effective if targeting GBMSM most at risk. It is unknown to what extent eligibility criteria for vaccination align with evidence on risk factors for mpox in GBMSM. Methods: We conducted an online self-report survey among GBMSM in the Netherlands between 29 July and 30 August 30, 2022, corresponding to the first month of the Dutch mpox vaccination campaign. GBMSM were recruited via advertisements on social media and gay dating apps. Participants reported on their sexual behaviour, mpox diagnosis, and/or vaccination since the start of the outbreak. Results: Of the 2,460 participants, 73 (3.0%) were diagnosed with mpox and 485 (19.7%) had been vaccinated. Using population sample weights, we estimated that, of the sexually active GBMSM population aged 18-80 years in the Netherlands, 1.1% had been diagnosed with mpox and 7.8% had been vaccinated. In multivariable logistic regression analyses, we found that current HIV-PrEP use, having 20 or more sex partners in the past 12 months and having sex in sex venues or at parties in the past two months were independent risk factors for mpox diagnosis.