Miracle-dz/UniFAR-FTUs huggingface dataset:
After‐school programmes response to the COVID‐19 pandemic: Lessons learned from Barcelona, Spain

Abstract This article explores the role of after‐school programmes (ASPs) in serving underserved families in Barcelona, Spain, during the lockdown phase of the COVID‐19 pandemic. Using a mixed‐method approach, this exploratory study surveyed 31 directors of ASPs administered by the Pere Tarrés Foundation. These ASPs serve almost 2000 children living under the federal poverty level in Catalonia, Spain. Results showed that the primary needs of children and their families revolved around: a digital divide that prevented them from accessing education remotely, financial difficulties, mental and behavioural problems and difficulty navigating pandemic‐related information. The study also explores the ASPs' contributions to address such needs, like engaging families, schools and social and health services to meet the urgent needs of the families, reinforcing school learning, providing support for managing emotions and providing guidance to families to help them better understand health information and gain access to available social and financial resources.
Made-up mouths with preen oil reveal genetic and phenotypic conditions of starling nestlings

Abstract Animal coloration results from pigments, nanostructures, or the cosmetic use of natural products, and plays a central role in social communication. The role of cosmetic coloration has traditionally been focused in scenarios of sexual selection, but it could also take place in other contexts. Here, by using spotless starlings (Sturnus unicolor) as a model system, we explore the possibility that nestlings cosmetically use their intensely yellow-colored uropygial secretion to signal their genetic and/or phenotypic quality. In agreement with the hypothetical cosmetic use of the uropygial secretion, (i) video recorded nestlings collected secretion with the bill at the age of feathering, (ii) cotton swabs turned to the color of secretion after rubbing with them nestlings’ gape, and (iii) gape and skin colorations correlated positively with that of secretion. Furthermore, we found that (iv) secretion coloration has a genetic component, and (v) associated positively with Vitamin E supplementation and (vi) with plasma carotenoid concentration, which highlights the informative value of nestling secretion. Finally, (vii) coloration of begging-related traits and of secretion of nestlings predicted parental feeding preferences. Consequently, all these results strongly suggest that the cosmetic use of colored uropygial secretion might also play a role in parent-offspring communication, complementing or amplifying information provided by the flamboyant colored gapes and skin of nestlings. The use of makeups by offspring for communication with relatives has been scarcely explored and we hope that these results will encourage further investigations in birds and other taxa with parental care.
Build Loyalty Through Experience Management

I SEPTEMBER 2007 I www.asq. org reat organizations establish strong emotional connections with their customers. Emotional connectivity with customers decommoditizes a business, elevating a brand beyond price and features to a higher level of meaning and commitment for customers. Connecting emotionally with customers requires an organization to create a cohesive, authentic and sensory-stimulating total customer experience that resonates, pleases, communicates effectively and differentiates the organization from the competition. Maintaining an emotional connection requires systematic management of the customers’ experiences with an organization and its offerings from the customers’ perspectives. Why is this important? Because it is the customers’ overall experiences with an organization and the goods or services it offers that evoke the perception of value that determines brand preference. Actual experiences of customers trump all else. It is important to systematically manage customers’ experiences. All organizations are service ones in the sense that all create value for customers through performances (services). Some firms are hybrids, creating value through manufactured goods and services. The services can facilitate the sale of the goods, directly generate revenue or do both. Other firms exclusively market services. But G
Computational fluid dynamics study of unconventional air vehicle configurations

Abstract Two unconventional micro air vehicles developed by the Naval Research Laboratory are described. One of the vehicles employs flapping wings which is inspired by the flight of birds or insects but does not copy it directly. The second vehicle is a stop-rotor hybrid vehicle employing a pair of single blade, rotary/fixed wing panels, attached at their roots to separate coaxial shafts. An unstructured grid based incompressible flow solver, called feflo, is used to simulate the flow past these novel configurations in order to determine the flight characteristics of these vehicles.
Supply Chain Management using Blockchain and Non-Fungible Tokens

Rapid globalisation and advancing technologies have connected the world, leading to businesses constantly trying to improve their supply chain for customer satisfaction and financial growth. Current solutions lack traceability and transparency with companies facing a 20% loss in goods every year. This report offers a potential solution by providing a blockchain-powered platform comprising a web and mobile application that utilises the power of NFTs. The supply chain member will transfer and accept the goods through the application that inherently conducts this process through tokenization of goods into NFTs. The Ethereum Blockchain is used because of its immutable nature, decentralisation and support of NFTs which further assist in the traceability of ownership. The businesses will be able to track the goods through another web portal offered as a part of the platform. The consumers will also be able to view and trace the origin of products at a store through the mobile application. Certain limitations have been identified in the platform, the key one revolving around the traceability of homogeneous goods from different suppliers. The current progress has revolved around research regarding the technical implementation, development of the mobile application for the supply chain members, and the tokenization of products into NFTs. The next steps involve integration of the application with the NFT tokenization process and creating the web dashboard for the supply chain managers. The report highlights the implementation, feasibility as well as the schedule for project development. Additionally, future plans include integration with Enterprise Resource Planning to create a trusted and traceable supply chain management system with features of accounting and smart analytics.
Vemurafenib effectively controlled Chemotherapy-refractory Intrahepatic Cholangiocarcinoma with BRAF V600E Mutation: a case report and literature review

Zusammenfassung Hintergrund Die Chemotherapie ist die erste Behandlungsoption für das lokal fortgeschrittene oder metastasierte intrahepatische Cholangiokarzinom (ICC). Nach einer Erstlinien-Chemotherapie gibt es jedoch keine Standardzweitlinienbehandlung oder zielgerichtete Wirkstoffe für diese Patienten. Fallpräsentation Hier stellen wir einen fortgeschrittenen ICC-Patienten vor, der eine radikale Entfernung und eine adjuvante Chemotherapie (Gemcitabin + Cisplatin) erhalten hat. Aber der Patient bleibt nur 6 Monate frei von Krankheitsanzeichen (No Evidence of Disease) nach dem Ende der Chemotherapie. Dann erhielt er eine palliative Operation, Strahlentherapie und systemische Chemotherapie (Tegafur+Oxaliplatin (SOX) und Nab-Paclitaxel+Gemcitabin (AG)). Leider war die Krankheit immer noch nicht unter Kontrolle. Als eine BRAF-V600E-Mutation im Tumorgewebe durch eine Next Generation Sequencing Analyse (NGS) gezeigt wurde, begann dieser Patient mit der Einnahme von Vemurafenib in einer Dosierung von 720–960 mg zweimal täglich und erreichte ein progressionsfreies Überleben von 7 Monaten mit signifikanter Remission der klinischen Symptome. Schlüsselwörter Die BRAF V600E Mutation ist bei ICC ziemlich selten, daher wird sie in der Klinik nicht routinemäßig untersucht. Allerdings kann Präzisionsmedizin durch die NGS-Technologie verwirklicht werden, sodass die Ärzte bei der Behandlung der auf Chemotherapie-refraktären ICC die personalisierten genomischen Informationen nutzen können.
Utilization, Spending, and Price of Opioid Medications in the US Medicaid Programs Between 1991 and 2019.

Background The opioid epidemic and drug abuse are critical public health challenges in the United States. The number of deaths from exceeding the recommended opioid dose is increasing. Objective To describe the recent trends in utilization, spending, and cost of opioid medications in the US Medicaid population between 1991 and 2019. Methods This retrospective, descriptive study was designed to evaluate the utilization of, spending on, and cost of opioids from 1991 to 2019 in the Medicaid population. We extracted data from the Centers for Medicare & Medicaid Services national Medicaid pharmacy files. The opioids received included fentanyl, meperidine, morphine, hydromorphone, oxymorphone, hydrocodone, hydrocodone plus acetaminophen, oxycodone, oxycodone plus acetaminophen, tapentadol, and tramadol. The number of prescriptions and reimbursement spending were calculated for each medication per quarter year. The average per-prescription reimbursement as a proxy of drug price was calculated as the reimbursement amount divided by the number of prescriptions per quarter year. The market shares by spending and utilization were also calculated for each opioid medication. Results The number of all opioid prescriptions in Medicaid increased from approximately 2.1 million in 1991 to approximately 41.6 million in 2015, and then reduced to approximately 19.1 million in 2019. During this 29-year study period, the opioid medications that were used as monotherapy were hydrocodone (246.8 million prescriptions), oxycodone (111.9 million prescriptions), and tramadol (75.2 million prescriptions). The total spending in the Medicaid population on opioids was $19.4 billion, including approximately $7.3 billion spending on oxycodone, approximately $3.7 billion on fentanyl, and approximately $3.3 billion on hydrocodone. The majority of opioid prices increased over time, and the highest average costs per opioid prescription in 2019 were $1188 for oxymorphone, $641 for tapentadol, and $198 for fentanyl. Conclusions The utilization of and spending on opioid medications in Medicaid increased over time, peaked in 2015, and then declined with the initiation of nationwide programs to combat the opioid epidemic. Effective cost-containment strategies and programs to combat the abuse of opioids are warranted in Medicaid programs.
Diterpenoids from Streptomyces: Structures, Biosyntheses and Bioactivities

Bacteria, especially Streptomyces spp. , have emerged as a rich source for natural diterpenoids with diverse structures and broad bioactivities. Here, we review diterpenoids biosynthesized by Streptomyces, with an emphasis on their structures, biosyntheses, and bioactivities. Although diterpenoids from Streptomyces are relatively rare compared to those from plants and fungi, their novel skeletons, biosyntheses and bioactivities present opportunities for discovering new drugs, enzyme mechanisms, and applications in biocatalysis and metabolic pathway engineering.
Factors affecting the first-born child's attitude toward the second child in Shanghai.

OBJECTIVE This study aimed to investigate factors associated with the attitude of the first-born child (FBC) towards the birth of the second child in China, in order to provide guidance for the preparation of a multi-child family. SUBJECTS AND METHODS A questionnaire, including requesting information for gender, age, health, parents' education and household income, was randomly distributed participating FBCs. The anxiety level, psychological, emotional and behavioral manifestations of the FBCs were evaluated. F-test and t-test were performed to identify significant factors associated with the FBC's attitude towards the second child. Out of the 65 surveys distributed, 61 were recovered and analyzed. RESULTS Our analysis indicated that female FBCs (total score vs. male, 45.38±4.02 vs. 42.95±4.29, p=0.031) with parents of higher education (p=0.020 in psychological and p=0.025 in behavioral manifestations) were in general more receptive to the second child. The FBC's health, school years and household income were not significant factors associated with their attitude towards the second child (p>0.05). Our analysis also found that the FBC's attitude towards the arrival of the second child was largely positive, and older children with parents of higher education were more likely to be receptive to the second child. CONCLUSIONS The findings of this study could provide guidance for parents to better prepare the psychological, emotional and behavioral states of the FBCs and family, enabling the FBCs with a positive attitude towards the second child. This finding is instrumental to promote a harmonious family atmosphere and growth environment for both the first- and second-born children.
Genome‐wide association studies in Japanese women identified genetic loci associated with wrinkles and sagging

Wrinkles and sagging are caused by various factors, such as ultraviolet rays; however, recent findings demonstrated that some individuals are genetically predisposed to these phenotypes of skin aging. The contribution of single nucleotide polymorphisms (SNPs) to the development of wrinkles and sagging has been demonstrated in genome‐wide association studies (GWAS). However, these findings were mainly obtained from European and Chinese populations. Limited information is currently available on the involvement of SNPs in the development of wrinkles and sagging in a Japanese population. Therefore, we herein performed GWAS on wrinkles at the outer corners of the eyes and nasolabial folds in 1041 Japanese women. The results obtained revealed that 5 SNPs (19p13.2: rs2303098 (p = 3.39 × 10−8), rs56391955 (p = 3.39 × 10−8), rs67560822 (p = 3.50 × 10−8), rs889126 (p = 3.78 × 10−8), rs57490083 (p = 3.99 × 10−8)) located within the COL5A3 gene associated with wrinkles at the outer corners of the eyes. Regarding nasolabial folds, 8q24.11 (rs4876369; p = 1.05 × 10−7, rs6980503; p = 1.25 × 10−7, rs61027543; p = 1.25 × 10−7, rs16889363; p = 1.38 × 10−7) was suggested to be associated with RAD21 gene expression. These SNPs have not been reported in other populations, and were first found in Japanese women population. These SNPs may be used as markers to examine the genetic predisposition of individuals to wrinkles and sagging.
Enhancing Atorvastatin In Vivo Oral Bioavailability in the Presence of Inflammatory Bowel Disease and Irritable Bowel Syndrome Using Supercritical Fluid Technology Guided by wbPBPK Modeling in Rat and Human

Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are common disorders that can change the body’s physiology and drugs pharmacokinetics. Solid dispersion (SD) preparation using supercritical fluid technology (SFT) has many advantages. Our study aimed to explore the effect of IBS and IBD on atorvastatin (ATV) pharmacokinetics, enhance ATV oral bioavailability (BCS II drug) using SFT, and analyze drug-disease-formulation interaction using a whole-body physiologically based pharmacokinetic (wbPBPK) model in rat and human. A novel ATV formulation was prepared using SFT and characterized in vitro and in vivo in healthy, IBS, and IBD rats. The resulting ATV plasma levels were analyzed using a combination of conventional and wbPBPK approaches. The novel formulation increased ATV solubility by 20-fold and resulted in a zero-order release of up to 95%. Both IBS and IBD increased ATV exposure after oral and intravenous administration by more than 30%. The novel SFT formulation increased ATV bioavailability by 28, 14, and 18% in control, IBD, and IBD rat groups and resulted in more consistent exposure as compared to raw ATV solution. Higher improvements in ATV bioavailability of more than 2-fold upon receiving the novel SFT formulation were predicted by the human wbPBPK model as compared to receiving the conventional tablets. Finally, the established wbPBPK model could describe ATV ADME in the presence of IBS and IBD after oral administration of raw ATV and using the novel SFT formula and can help scale the optimized ATV dosing regimens in the presence of IBS and IBD from rats to humans.
Nanohybrids that consisit of p-type, nitrogen-doped ZnO and graphene nanostructures: synthesis, photophysical properties, and biosensing application

ZnO, a promising material for optoelectronic applications, has attracted considerable attention due to its wide and direct band gap and large exciton binding energy. To understand the applications of this material, fabrication of high quality p-type ZnO is a key step. However, a reliable p-type doping of this material remains a major challenge. In this study, we report p-type nitrogen-doped ZnO nanoparticle, grown in a nitrogen doped graphene layer matrix by a plasma heating process using a natural protein and zinc nitrate as the precursors. The structural characterizations are developed by several microscopic techniques including the field emission electron microscopy, high resolution transmission electron microscopy, x-ray photoelectron spectroscopy, and micro-Raman analysis. In addition, the ultraviolet (UV)–visible absorption characteristics and photoluminescence properties of the samples are studied. Its p-type conduction behaviour is confirmed by the Hall effect measurement, which was ascribed to the high nitrogen dopant concentration in the Zn-poor ZnO, and the related mechanism for the p-type behaviour is also discussed. Moreover, the results of the glucose detection based on the strong green luminescence of glucose indicate that the nitrogen-doped ZnO nanodots/nitrogen-doped graphene layer nanohybrid is also a competitive candidate in the biosensing field.
Building an Intelligent Health System Using an Evolutionary Architectural Model of Middleware

Health Information Systems in industry are undergoing a paradigm shift in uniformity. The needs for health professionals to utilize universal patient records require various legacy health applications to be integrated in a logical, orderly process. The Smart Hospital Management System is an infrastructure solution that seeks to unify health patient management subsystems together while retaining the existing performance and reliability requirements of the individual subsystems. The infrastructure oriented application of The Open Group Architecture Framework, presented in this research work, ensures that integrity and an enterprise-level perspective are considered throughout the development process. This includes a consideration of the problem space and scenarios, constraints, requirements, risks, enablers and inhibitors of the legacy application architectures. The proposed integration solution with TOGAF components, addresses the need for health institutions to unify their legacy operations in a consistent and best practice compliant manner to ensure universal patient records are thorough, comprehensive and provide robust security mechanisms to make certain that privacy regulation compliance and protection against identity theft are vital. 
Stomata on the abaxial and adaxial leaf surfaces contribute differently to leaf gas exchange and photosynthesis in wheat

Summary Although stomata are typically found in greater numbers on the abaxial surface, wheat flag leaves have greater densities on the adaxial surface. We determine the impact of this less common stomatal patterning on gaseous fluxes using a novel chamber that simultaneously measures both leaf surfaces. Using a combination of differential illuminations and CO2 concentrations at each leaf surface, we found that mesophyll cells associated with the adaxial leaf surface have a higher photosynthetic capacity than those associated with the abaxial leaf surface, which is supported by an increased stomatal conductance (driven by differences in stomatal density). When vertical gas flux at the abaxial leaf surface was blocked, no compensation by adaxial stomata was observed, suggesting each surface operates independently. Similar stomatal kinetics suggested some co‐ordination between the two surfaces, but factors other than light intensity played a role in these responses. Higher photosynthetic capacity on the adaxial surface facilitates greater carbon assimilation, along with higher adaxial stomatal conductance, which would also support greater evaporative leaf cooling to maintain optimal leaf temperatures for photosynthesis. Furthermore, abaxial gas exchange contributed c. 50% to leaf photosynthesis and therefore represents an important contributor to overall leaf gas exchange.
Granule Cells Constitute One of the Major Neuronal Subtypes in the Molecular Layer of the Posterior Cerebellum

Abstract The migration of neurons from their birthplace to their correct destination is one of the most crucial steps in brain development. Incomplete or incorrect migration yields ectopic neurons, which cause neurologic deficits or are negligible at best. However, the granule cells (GCs) in the cerebellar cortex may challenge this traditional view of ectopic neurons. When animals are born, GCs proliferate near the pia mater and then migrate down to the GC layer located deep in the cerebellar cortex. However, some GC-like cells stay in the molecular layer, a layer between the pia mater and GC layer, even in normal adult animals. These cells were named ectopic GCs nearly 50 years ago, but their abundance and functional properties remain unclear. Here, we have examined GCs in the molecular layer (mGCs) with a specific marker for mature GCs and transgenic mice in which GCs are sparsely labeled with a fluorescent protein. Contrary to the previous assumption that mGCs are a minor neuronal population, we have found that mGCs are as prevalent as stellate or basket cells in the posterior cerebellum. They are produced during a similar period as regular GCs (rGCs), and in vivo time-lapse imaging has revealed that mGCs are stably present in the molecular layer. Whole-cell patch-clamp recordings have shown that mGCs discharge action potentials similarly to rGCs. Since axonal inputs differ between the molecular layer and GC layer, mGCs might be incorporated in different micro-circuits from rGCs and have a unique functional role in the cerebellum.