Miracle-dz/UniFAR-FTUs huggingface dataset:
Counseling in menopausal women: How to address the benefits and risks of menopause hormone therapy. A FIGO position paper

Menopause marks the end of menstrual cyclicity and, depending on individual vulnerability, has several consequences related to gonadal steroid deprivation, especially if it is premature. Menopause may be more burdensome for some women than for others. Individual factors, such as personal history, socioeconomic status, ethnicity, and current health conditions, affect symptomatology and, thereby, the menopausal experience. In addition, some menopausal symptoms, such as severe hot flashes, sleep disorders, and depression, are markers of future health risks. Counseling is a fundamental part of health care in the peri‐ and postmenopause periods. It must include an assessment of the patient's symptoms, needs, desires, and risk profile to address the benefits and risks of menopausal hormone therapy (MHT) on an individual basis and promote a healthy lifestyle. Indeed, healthcare practitioners can and must protect the health and lives of mid‐life women by increasing awareness of menopausal symptoms and ensuring healthcare options, especially MHT. The type and duration of MHT should be tailored based on the patient's history, menopausal age, physical characteristics, and current health status so that the benefits always outweigh the risks. This FIGO position paper focuses on the benefits and risks of MHT on health domains, target organs, and systems, and on systemic and vaginal MHT regimens, to provide indications that can be used in the clinical practice for menopausal counseling. Moreover, it offers insights into what FIGO considers the mainstay for the healthcare management of women in peri‐ and postmenopause, worldwide.
“In My Mind, It Was Just Temporary”: A Qualitative Study of the Impacts of Cancer on Men and Their Strategies to Cope

Individuals who are diagnosed and treated for cancer use a variety of strategies to manage its impacts. However, there is currently a lack of research on men’s experience with managing cancer impacts, which is necessary to better support them throughout the cancer care continuum. This study explored the experience of men diagnosed with cancer, focusing on the impacts of the illness and its treatment and men’s strategies to cope. A qualitative descriptive design was used. Thirty-one men (Mage = 52.7 [26–82] years) diagnosed with various cancer types were recruited to take part in individual telephone interviews (n = 14) or online focus groups (n = 17) addressing the impacts of cancer and strategies they used to cope with these impacts. Directed content analysis was performed, using Fitch’s (2008) supportive care framework to guide the analysis. Cancer impacts and strategies used to cope were classified into six categories: physical, psychological, interpersonal, informational, practical, and spiritual. Results indicate that the cancer experience is diverse and multifaceted rather than homogeneous. Medical and supportive care services could be more effectively personalized to meet the diversity of men’s needs by adopting a comprehensive and holistic approach to supportive care. Working in partnership with patients, it appears promising to recognize and identify men’s needs and match them to appropriate resources to provide truly supportive care.
Influence of the choice of b-values and fitting constrains on the calculation of f-maps by intravoxel incoherent motion in human healthy kidneys

Poster: "ECR 2013 / C-1927 / Influence of the choice of b-values and fitting constrains on the calculation of f-maps by intravoxel incoherent motion in human healthy kidneys" by: "M. Kaul, S. Galler, C. R. Habermann, G. B. Adam, J. Hermann; Hamburg/DE"
Beach Tourism in Nigeria: A Case Study of Elegushi Beach Resort, Lagos State

reasoning” (Encarta cited in Okpoko,(ed) 2006). Marx (1963),opined that theories integrate and order empirical findings; they are an economical and efficient means for abstracting, codifying, summarizing, integrating and storing information. In other words, theories provide both knowledge and tool for tourism development. However, there are so many theories applicable to tourism, but since we are dealing with beach tourism, emphasis will be laid on few theories concerning it. 2.1. 1 SYSTEMS THEORY A system according to Ludwig Von Bertalanffy (1976) who propounded the theory “is a set of elements standing in interrelation among themselves with the environments”. For Leiper (1990), a system can be defined as a set of elements or parts that are connected to each other by at least one distinguishing principle. In this case, tourism is the distinguishing principle which connects the different components in the system around a common theme. Everything is connected, there are systems within systems and everything influences and is influenced by everything else. Easton (1953), stated further that a system need not react to disturbances just by oscillating in the neighbourhood of a prior point of equilibrium or by shifting to a new one. It may cope with the disturbance by seeking to change its environment so
3D Hydrogel Encapsulation Regulates Nephrogenesis in Kidney Organoids.

Stem cell-derived kidney organoids contain nephron segments that recapitulate morphological and functional aspects of the human kidney. However, directed differentiation protocols for kidney organoids are largely conducted using biochemical signals to control differentiation. Here, the hypothesis that mechanical signals regulate nephrogenesis is investigated in three-dimensional culture by encapsulating kidney organoids within viscoelastic alginate hydrogels with varying rates of stress relaxation. Tubular nephron segments are significantly more convoluted in kidney organoids differentiated in encapsulating hydrogels when compared with those in suspension culture. Hydrogel viscoelasticity regulates the spatial distribution of nephron segments within the differentiating kidney organoids. Consistent with these observations, a particle-based computational model predicts that the extent of deformation of the hydrogel-organoid interface regulates the morphology of nephron segments. Elevated extracellular calcium levels in the culture medium, which can be impacted by the hydrogels, decrease the glomerulus-to-tubule ratio of nephron segments. These findings reveal that hydrogel encapsulation regulates nephron patterning and morphology and suggest that the mechanical microenvironment is an important design variable for kidney regenerative medicine. This article is protected by copyright. All rights reserved.
A rare case of extrarenal Wilms tumor of the uterine corpus: comprehensive genomic profile and review of the literature

Summary Wilms tumor (WT), or nephroblastoma, is an uncommon malignant neoplasm occurring in the kidney of pediatric patients. Its extrarenal location is extremely rare and has been reported in various sites, including the female genital tract, with only 9 cases arising in the uterine corpus. We present the case of an adult woman who underwent total abdominal hysterectomy due to a uterine mass causing persistent abdominal pain. The characteristic triphasic morphology (composed of epithelial, stromal, and blastemal elements) supported by a broad immunohistochemical panel, along with the imaging exclusion of a renal neoplasm, was diagnostic of WT of the uterus. For the first time, a comprehensive genomic profiling of a uterine primary WT was also performed by next-generation sequencing, disclosing alterations at the level of copy number variations in the genes ERBB2, FGFR23, FGF6, FGFR2, and RPS6KB1. All previously reported uterine cases were reviewed, with a summary of their main clinicopathologic characteristics, and the main differential diagnoses are presented. Further reports are needed to improve our knowledge about prognostic factors, clinical behavior and molecular alterations that could guide appropriate therapeutic decision making.
Attention Connect Network for Liver Tumor Segmentation from CT and MRI Images

Introduction: Currently, the incidence of liver cancer is on the rise annually. Precise identification of liver tumors is crucial for clinicians to strategize the treatment and combat liver cancer. Thus far, liver tumor contours have been derived through labor-intensive and subjective manual labeling. Computers have gained widespread application in the realm of liver tumor segmentation. Nonetheless, liver tumor segmentation remains a formidable challenge owing to the diverse range of volumes, shapes, and image intensities encountered. Methods: In this article, we introduce an innovative solution called the attention connect network (AC-Net) designed for automated liver tumor segmentation. Building upon the U-shaped network architecture, our approach incorporates 2 critical attention modules: the axial attention module (AAM) and the vision transformer module (VTM), which replace conventional skip-connections to seamlessly integrate spatial features. The AAM facilitates feature fusion by computing axial attention across feature maps, while the VTM operates on the lowest resolution feature maps, employing multihead self-attention, and reshaping the output into a feature map for subsequent concatenation. Furthermore, we employ a specialized loss function tailored to our approach. Our methodology begins with pretraining AC-Net using the LiTS2017 dataset and subsequently fine-tunes it using computed tomography (CT) and magnetic resonance imaging (MRI) data sourced from Hubei Cancer Hospital. Results: The performance metrics for AC-Net on CT data are as follows: dice similarity coefficient (DSC) of 0.90, Jaccard coefficient (JC) of 0.82, recall of 0.92, average symmetric surface distance (ASSD) of 4.59, Hausdorff distance (HD) of 11.96, and precision of 0.89. For AC-Net on MRI data, the metrics are DSC of 0.80, JC of 0.70, recall of 0.82, ASSD of 7.58, HD of 30.26, and precision of 0.84. Conclusion: The comparative experiments highlight that AC-Net exhibits exceptional tumor recognition accuracy when tested on the Hubei Cancer Hospital dataset, demonstrating highly competitive performance for practical clinical applications. Furthermore, the ablation experiments provide conclusive evidence of the efficacy of each module proposed in this article. For those interested, the code for this research article can be accessed at the following GitHub repository: https://github.com/killian-zero/py_tumor-segmentation.git.
Association between normal saline infusion volume in the emergency department and acute kidney injury in heat stroke patients: a multicenter retrospective study

Abstract Background Previous studies have shown that intravenous normal saline (NS) may be associated with the incidence of acute kidney injury (AKI). This study aimed to evaluate the association between the volume of NS infusion and AKI in heat stroke (HS) patients. Methods This multicenter retrospective cohort study included 138 patients with HS. The primary outcome was the incidence of AKI. Secondary outcomes included the need for continuous renal replacement therapy (CRRT), admission to the intensive care unit (ICU), length of stay in the ICU and hospital, and in-hospital mortality. Multivariate regression models, random forest imputation, and genetic and propensity score matching were used to explore the relationship between NS infusion and outcomes. Results The mean volume of NS infusion in the emergency department (ED) was 3.02 ± 1.45 L. During hospitalization, 33 patients (23.91%) suffered from AKI. In the multivariate model, as a continuous variable (per 1 L), the volume of NS infusion was associated with the incidence of AKI (OR, 2.51; 95% CI, 1.43–4.40; p = .001), admission to the ICU (OR, 3.46; 95% CI 1.58–7.54; p = .002), and length of stay in the ICU (β, 1.00 days; 95% CI, 0.44–1.56; p < .001) and hospital (β, 1.41 days; 95% CI, 0.37–2.45; p = .008). These relationships also existed in the forest imputation cohort and matching cohort. There were no differences in the use of CRRT or in-hospital mortality. Conclusions The volume of NS infusion was associated with a significant increase in the incidence of AKI, admission to the ICU, and length of stay in the ICU and hospital among patients with HS.
Impacts of climate change on mid‐twenty‐first‐century rainfall in Ireland: a high‐resolution regional climate model ensemble approach

The impacts of climate change on precipitation over Ireland are assessed for the mid‐century period 2041–2060 using an ensemble of downscaled climate simulations, based on medium‐to‐low and high emission scenarios. Results show significant projected decreases in mean annual, spring and summer precipitation amounts by mid‐century. The projected decreases are largest for summer, with reductions ranging from 0 to 13% and from 3 to 20% for the medium‐to‐low and high emission scenarios, respectively. The frequencies of heavy precipitation events show notable increases of approximately 20% during the winter and autumn months. The number of extended dry periods is projected to increase substantially by mid‐century during autumn and summer. The projected increases in dry periods are largest for summer, with values ranging from 12 to 40% for both emission scenarios. Regional variations of projected precipitation change remain statistically elusive.
Water Ingestion in Postural Orthostatic Tachycardia Syndrome: A Feasible Treatment Option?

As noted by Ziffra et al.,1 although not completely understood, the pathophysiology of postural orthostatic tachycardia syndrome (POTS) appears to be multifactorial. Autonomic nervous system dysfunction,2 increased sympathetic tone,3 and physical deconditioning4,5 are some of the suggested contributory factors. As such, the recording of a detailed history and the performance of a thorough physical examination including measuring orthostatic parameters are crucially important.
Does gender influence forest management?: Exploring cases from East Africa and Latin America

The influence of gendered relationships on access to forests and on forest sustainability remains a concern for scholars and practitioners. This paper presents a comparative study of forest management across four countries in East Africa and Latin America: Kenya, Uganda, Bolivia and Mexico. It focuses on one question: Do varying proportions of women (low, mixed, high) in forest user groups influence their likelihood of adopting forest resource enhancing behavior? We found that higher proportions of females in user groups, and especially user groups dominated by females, perform less well than mixed groups or male dominated ones. We suggest that these differences may be related to three factors: gender biases in technology access and dissemination, a labor constraint faced by women and a possible limitation to women’s sanctioning authority. Mixed female and male groups offer an avenue for exploiting the strengths of women and men, while tempering their individual shortcomings.
Incompatibility of antimalarial drugs: challenges in formulating combination products for malaria

Abstract Lipophilic drugs require more advance formulation, especially if the intention is to make solutions or semisolid formulations. This also accounts for most antimalarial drugs. Although some of these antimalarial drugs are soluble in lipid vehicles, few of them, such as lumefantrine (LF), are also poorly soluble in oily vehicles. Trying to dissolve and formulate LF as a liquid formulation together with other antimalarial drugs is, therefore, a major task. When mixed in solution together with artemether (AR), precipitation occurs, sometimes with LF precipitating out on its own, and sometimes with AR precipitating out alongside LF. In this study, it was hypothesized that the use of fatty acids could lead to enhanced solubility in lipid formulation. Addition of the fatty acid solved the dissolution challenges, making LF soluble for over a year at room temperature (21–23 °C); but further research is needed to test the mechanism of action of the fatty acid. In addition, design of experiments (MODDE® 13) revealed that the amount of fatty acid in the formulation was the only significant factor for LF precipitation.
Role of hospitalisation for substance misuse in marital status transitions: a 47-year follow-up of a Swedish birth cohort

Background Substantial research suggests that the risk of substance misuse is higher among individuals who remain unmarried or experience marital dissolution, whereas marriage tends to be protective. However, few studies have considered the role of substance misuse for transitions between discrete marital status categories. The current study aims to estimate associations between substance misuse and marital status transitions from ages 20–66. Methods Our study population was a national Swedish cohort born in 1953 (n=71 901), followed from 1973 to 2019. Annual marital status and hospitalisation records for substance misuse were derived from the Total Population and National Patient registers, respectively. We used a five-state multistate model to estimate associations between substance misuse and marital status transitions—the state space included never married, married, divorced and widowed with death as the absorbing state. We further used fixed-effect models to estimate the effects of substance misuse on transitions out of marriage. Results Findings suggested that individuals’ substance misuse was associated with an increased risk of transitioning from married to divorced (HR=3.54, 95% CI 3.40 to 3.69) or widowed (HR=1.71, 95% CI 1.46 to 2.01), and transitioning to death from all states. Substance misuse was also negatively associated with transitioning from never married to married (HR=0.59, 95% CI 0.57 to 0.61), and into remarriage after divorce (HR=0.86, 95% CI 0.80 to 0.92). The fixed-effect results suggested that substance misuse increased the risk of transitioning to divorce and widowhood, net of sociodemographic characteristics. Conclusion Substance misuse is associated with an increased risk of marital dissolution and death when accounting for nearly 50 years of marital biographies.
Heightened long-term cardiovascular risks after exacerbation of chronic obstructive pulmonary disease

Objective To examine the risk of adverse cardiovascular (CV) events following an exacerbation of chronic obstructive pulmonary disease (COPD). Methods This retrospective cohort study identified patients with COPD using administrative data from Alberta, Canada from 2014 to 2019. Exposure periods were 12 months following moderate or severe exacerbations; the reference period was time preceding a first exacerbation. The primary outcome was the composite of all-cause death or a first hospitalisation for acute coronary syndrome, heart failure (HF), arrhythmia or cerebral ischaemia. Time-dependent Cox regression models estimated covariate-adjusted risks associated with six exposure subperiods following exacerbation. Results Among 1 42 787 patients (mean age 68.1 years and 51.7% men) 61 981 (43.4%) experienced at least one exacerbation and 34 068 (23.9%) died during median follow-up of 64 months. The primary outcome occurred in 43 564 (30.5%) patients with an incidence rate prior to exacerbation of 5.43 (95% CI 5.36 to 5.50) per 100 person-years. This increased to 95.61 per 100 person-years in the 1–7 days postexacerbation (adjusted HR 15.86, 95% CI 15.17 to 16.58) and remained increased for up to 1 year. The risk of both the composite and individual CV events was increased following either a moderate or a severe exacerbation, though greater and more prolonged following severe exacerbation. The highest magnitude of increased risk was observed for HF decompensation (1–7 days, HR 72.34, 95% CI 64.43 to 81.22). Conclusion Moderate and severe COPD exacerbations are independent risk factors for adverse CV events, especially HF decompensation. The impact of optimising COPD management on CV outcomes should be evaluated.
Explicit Effects and Effect Constraints in ReML

An important aspect of building robust systems that execute on dedicated hardware and perhaps in constrained environments is to control and manage the effects performed by program code. We present ReML, a higher-order statically-typed functional language, which allows programmers to be explicit about the effects performed by program code and in particular effects related to memory management. Allowing programmers to be explicit about effects, the regions in which values reside, and the constraints under which code execute, makes programs robust to changes in the program source code and to compiler updates, including compiler optimisations. ReML is integrated with a polymorphic inference system that builds on top of region-inference, as it is implemented in the MLKit, a Standard ML compiler that uses region-based memory management as its primary memory management scheme.
The Complex(ity) Landscape of Checking Infinite Descent

Cyclic proof systems, in which induction is managed implicitly, are a promising approach to automatic verification. The soundness of cyclic proof graphs is ensured by checking them against a trace-based Infinite Descent property. Although the problem of checking Infinite Descent is known to be PSPACE-complete, this leaves much room for variation in practice. Indeed, a number of different approaches are employed across the various cyclic proof systems described in the literature. In this paper, we study criteria for Infinite Descent in an abstract, logic-independent setting. We look at criteria based on Büchi automata encodings and relational abstractions, and determine their parameterized time complexities in terms of natural dimensions of cyclic proofs: the numbers of vertices of the proof-tree graphs, and the vertex width—an upper bound on the number of components (e.g., formulas) of a sequent that can be simultaneously tracked for descent. We identify novel algorithms that improve upon the parameterised complexity of the existing algorithms. We implement the studied criteria and compare their performance on various benchmarks.
Privacy Preserving Multi-source Cross-domain Recommendation based on Knowledge Graph

The cross-domain recommender systems aim to alleviate the data sparsity problem in the target domain by transferring knowledge from the auxiliary domain. However, existing works ignore the fact that the data sparsity problem may also exist in the single auxiliary domain, and sharing user behavior data is restricted by the privacy policy. In addition, their cross-domain models lack interpretability. To address these concerns, we propose a novel multi-source cross-domain model based on knowledge graph. Specifically, to avoid the insufficiency of single auxiliary domain, we construct a knowledge graph comprehensively leveraging items from multiple auxiliary domains. In order to avoid the leakage of user privacy when user information is transferred to multiple domains, we construct graph for information transfer between items to effectively avoid the propagation of users’ private information between different domains. We implicitly integrate the user-item interaction by transferring the learned item embeddings. To improve the interpretability of cross-domain knowledge transfer, we propose a knowledge graph-based retrieval and fusion method to transfer knowledge derived from multiple auxiliary domains. An attention-based fusion network is designed to enhance the representation of the targeted user and items with the transferred item embedding. We perform extensive experiments on three real-world datasets, demonstrating that our model outperforms the state-of-the-arts.