Miracle-dz/UniFAR-FTUs huggingface dataset:
FORMULATION AND ASSESSMENT OF HERBAL EMULGELS IN THE MANAGEMENT OF ACNE: IN VITRO AND IN VIVO INVESTIGATIONS

Objective: The main objective of the current research was to prepare herbal emulgel and analyze the effect of herbal formulation in the treatment of acne. Methods: The plants Tabernaemontana coronaria and Thunbergia alata were selected for the study because of folklore for their medicinal values. The T. coronaria and T. alata test extracts were prepared by soxhlet extraction procedure and subjected to physico-chemical evaluation. The formulated herbal emulgels prepared by dispersion technique were investigated for anti-acne properties by in vitro and in vivo methods. The prepared emulgel formulations were assessed for parameters like viscosity, spreadability, pH, content uniformity, stickiness, zeta potential, particle size, surface morphology, and in vitro diffusion studies. Results: The physico-chemical evaluation of herbal gel revealed that emulgel appeared light green in colour, opaque, and odourless with smooth texture. The emulgels of both the test extracts showed no stickiness, and revealed pH ranging from 5.467±0.13 to 5.889±0.1. When the shear rate was increased, there was a decrease in the viscosity of the test emulgels, with good extrudability. The content uniformity of F5 emulgel for T. coronaria and T. alatawas 99%, and spreadibilty was more with F7 formulation of T. coronaria and F6 formulation of T. alata, respectively. In the stability testing studies, amongst all the formulations prepared, F5 was found to be stable upon storage for six months. In vitro studies, F5 formulation of both the test extracts had a remarkable zone of inhibition; whereas F5 formulation treated histopathological sections in in vivo investigation displayed a decline in the overall damage induced by Propionibacterium acnes. The results showed no statistical significant difference for measurement of zone of inhibition and histopthological studies between the test formulations and standard drug. Conclusion: The study concludes that both herbal formulations were promising agents for the treatment of acne vulgaris.
Fauna and Flora of the Japanese Islands in the Last Glacial Time

This article deals with introducing some problems being debated by the members of the Research Group, relating to the fauna and flora of the Japanese Islands in the Last Glacial time. Though nowhere in Japan the precise chronostratigraphy of this age has been established yet, a tentative clasification based on litho- and biostratigraphy in central Japan by J. SAKAI and others is proposed with tephrochronology and radiometric dating. According to them, the Early stage began with the regression and advent of cold phase of ca. 65, 000yr.B.P., and further with the Middle stage chracterized by climatic ossilation, some peculiar warm phases were corporated. In the Late stage between 25, 000yr.B.P. and 10, 000yr.B.P. was intercalated the maximal cold phase of ca. 20, 000yr. B.P.Concerning the reconstruction of paleoenvironment, I. HIURA made biogeographical and ecological consideration by paying his attention to the species and subspecies distribution of non-dispersal plants and insects like as tribe ASAREAE and tribe CARABINI respectively. On the other hand, the vegetation of the Japanese Islands and its adjacent areas was investigated from the recent and Last Glacial plant geography by M. HOTTA and T. NASU respectively. They suggest significance of the distribution of plant communities to the seasonal structure of precipitation rather than to the temperature control. Summing up those results collectively, the environmental and vegetational studies on the Last Glacial seem to indicate the presence of more arid and extensive steppe-like environment which is absent in the present Japanese Islands.It is characteristic that some of the arctic mammals migrated into Honshu through northern land connection during the Last Glacial. Therefore, the mammalian fauna in that time was composed of arctic immigrants and temperate endemics, that is the mixed fauna. In this sence, that mixed fauna may resemble to the present of mammals in the Maritime Province (Siberia) and Manchuria of the continent. The immigration of those arctic mammals might be undertaken before the maximal phase of ca. 20, 000yr.B.P. In connection with this, the sea level change of those days was discussed. It may probable to say that the lowest sea level was -100m± as being discussed by M. HOSHINO and that the southern land connection did not happen at that time.
Rayleigh waves from a moving thrust fault

The amplitude of the Rayleigh waves produced by a finite, propagating dip-slip fault of arbitrary orientation in a homogeneous, isotropic half-space is obtained. The fault is assumed to initiate suddenly at depth and to spread unilaterally to the free surface with constant speed. The Rayleigh-wave amplitude ahead of the fault break is shown to be considerably higher than that behind the initial epicenter. There is severe amplitude modulation in the epicentral region caused by the interference of waves traveling in opposite directions. The numerical results indicate that for Rayleigh waves in the period range of interest in earthquake engineering, a number of simplifications can be made in modeling an earthquake source of this type.
Dense Hybrid Attention Network for Palmprint Image Super-Resolution

Palmprint has attracted increasing attention for biometric recognition in recent years due to its outstanding reliability, user-friendliness and hygiene. However, existing palmprint recognition methods usually require high-quality palmprint images with clear texture and line patterns; however, in practical applications palmprint images are usually of low quality. In this study, we propose a dense hybrid attention (DHA) network for palmprint image super-resolution (SR) by recovering the clear palmprint-specific characteristics. The proposed DHA network first obtains the high-dimensional shallow representation via a single convolution layer, and then jointly learns the local and global palmprint-specific features via parallel convolutional neural network (CNN)- and transformer-based branches. Particularly, we develop two enhanced spatial and channel attention (CA) modules to adaptively emphasize the local position-specific characteristics of palmprints, such that the SR palmprint images can be well recovered with clear texture and edge characteristics. Experimental results on three publicly used palmprint databases clearly show the effectiveness of the proposed method for palmprint image SR.
EVALUSI SISTEM INFORMASI PELAYANAN PERIZINAN BERUSAHAAN SEKTOR INDUSTRI MELALUI ONLINE SINGLE SUBMISSION BERBASIS METODE TECHNOLOGY ACCEPTANCE MODEL DI DPM PTSP KABUPATEN GRESIK

The Online Single Submission (OSS) system has a very positive impact on business actors in making permit applications faster and simpler. The application of the OSS system requires an evaluation regarding the acceptance of the system. This is done so that it becomes a benchmark to assess the acceptance of an information technology by users. This research is motivated to analyze the acceptance of the Online Single Submission (OSS) information system using the Technology Acceptance Model (TAM). This method uses the TAM method, namely the user's perception of the ease of using technology (Perceived Ease of Use), the user's perception of the benefits / usefulness of technology (Perceived Usefulness), acceptance of information systems (Acceptance of IT) accepted by the community. This research was conducted by t-test and F-test. The results of the analysis show that the significant value in hypothesis-1 and hypothesis-2 indicates that the significance value is more than 0.05, which means that variable X has a significant effect on variable Y.
Efficient Cross-Modality Insulator Augmentation for Multi-Domain Insulator Defect Detection in UAV Images

Regular inspection of the insulator operating status is essential to ensure the safe and stable operation of the power system. Unmanned aerial vehicle (UAV) inspection has played an important role in transmission line inspection, replacing former manual inspection. With the development of deep learning technologies, deep learning-based insulator defect detection methods have drawn more and more attention and gained great improvement. However, former insulator defect detection methods mostly focus on designing complex refined network architecture, which will increase inference complexity in real applications. In this paper, we propose a novel efficient cross-modality insulator augmentation algorithm for multi-domain insulator defect detection to mimic real complex scenarios. It also alleviates the overfitting problem without adding the inference resources. The high-resolution insulator cross-modality translation (HICT) module is designed to generate multi-modality insulator images with rich texture information to eliminate the adverse effects of existing modality discrepancy. We propose the multi-domain insulator multi-scale spatial augmentation (MMA) module to simultaneously augment multi-domain insulator images with different spatial scales and leverage these fused images and location information to help the target model locate defects with various scales more accurately. Experimental results prove that the proposed cross-modality insulator augmentation algorithm can achieve superior performance in public UPID and SFID insulator defect datasets. Moreover, the proposed algorithm also gives a new perspective for improving insulator defect detection precision without adding inference resources, which is of great significance for advancing the detection of transmission lines.
Impact of Monitoring Vancomycin Peak and Trough Concentrations versus Trough Concentrations Alone on Dose Adjustments: An Outcomes Analysis

Objective: To determine whether monitoring both steady-state peak and trough serum vancomycin concentrations or steady-state trough serum vancomycin concentrations alone resulted in differences between two groups of patients in terms of dose adjustment, clinical outcome, and toxicity. Design: The study was a retrospective chart review of patients treated with vancomycin during two time periods. Group 1 represented patients hospitalized between July 1, 1996, and January 31, 1997. These patients routinely had vancomycin peak and trough concentrations measured. Group 2 represented patients hospitalized from July 1, 1997, to January 31, 1998, who were monitored with trough vancomycin concentrations only. Setting: A university teaching hospital. Patients: Adults at least 18 years of age who received a constant dose of intravenous vancomycin for at least three consecutive days were eligible for inclusion in the study. Patients were selected from lists generated by the Microbiology Department. The lists contained vancomycin serum concentrations measured during those time frames. Main Outcome Measures: The main outcome measure was to assess whether dose adjustments by prescribers were influenced by both vancomycin peak and trough concentrations or by the trough concentration alone. Results: Forty-nine and 37 patients met the criteria for inclusion into group 1 and group 2, respectively. The mean duration of therapy in group 1 (15 ± 10 d) was not statistically different from that of group 2 (14 ± 12 d). Patients in both groups received a mean daily vancomycin dose of approximately 1,500 mg. In analyzing treatment decisions, trough concentration was the only significant factor influencing a change in total daily dose of vancomycin (p = 0.038). Furthermore, although the method of vancomycin serum concentration monitoring varied between the two groups, the mean clinical outcome parameters were comparable. Conclusions: Prescribers tended to adjust vancomycin regimens based only on trough serum concentrations; monitoring peak serum vancomycin concentrations did not enhance patient care. Mean outcome parameters in the two groups were comparable.
Biocontrol: Could the Agroecosystem be the Starting Point for New Human Infection? A Review

Biocontrol is defined as the use of living organism to control pests, also resulting in plant growth promotion. Due to the beneficial effects of many microbes on plant health, their use in agriculture is going to increase rapidly and widely, also stimulated by the recent Integrated Pest Management rules. Nevertheless, their impact on human health and environment is still poorly investigated. Unfortunately, some of the commercial products are based on biocontrol agents that are reported in literature as true or opportunistic human and animal pathogens or phylogenetically closest relatives, such as Pantoea, Burkholderia, Pseudomonas or Paenibacillus. This evidence in combination with the outbreaks of human infections associated with consumption of raw fruits and vegetables open new questions on the role of agroecosystem in the human pathogen infection cycle.
An Anomalous Genesis Potential Index for MJO Modulation of Tropical Cyclones

AbstractModulation of tropical cyclone (TC) genesis by the Madden–Julian oscillation (MJO) has been quantitatively diagnosed by using a climatological genesis potential index (GPI). Analysis of TC genesis during November–April of 1979–2014 indicates the most effective factors controlling intraseasonal TC genesis are 850-hPa relative vorticity weighted by the Coriolis parameter fζr850 and 500-hPa vertical motion ω500. The total vertical wind shear and maximum potential intensity are unimportant, and the role of 600-hPa relative humidity is greatly represented by ω500. The MJO modulates TC genesis primarily through changing low-level vorticity induced by its Rossby wave gyres and meridional shears of equatorial zonal winds. A new intraseasonal GPI (ISGPI) is proposed to quantify the MJO’s modulation of TC genesis. The ISGPI significantly improves representation of intraseasonal variation of TC genesis in the tropics and in each subregion of the southern Indian Ocean, Australian monsoon, and South Pacific. I.
Synthesis of Graphene Aerogel for Adsorptive Removal of Tetracycline from Water: Impact of Operating Parameters

Graphene aerogel (GA) was synthesized by chemical reduction of graphene oxide (GO) using ethylene diamine as a reducing agent, which was then followed by a freeze-drying process. The morphology and surface properties of GA, GO samples were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDX), and Brunauer-Emmett-Teller (BET). GA was then used to study the adsorption process of tetracycline (TC) in aqueous solutions. Different parameters influencing the adsorption efficiency of GA such as pH, adsorbent load, initial concentration of TC, contact time were investigated. The results showed that when GO was transformed to GA, the XRD characteristic peak at about 10.8˚ was shifted to broad peaks at 26˚ and 43˚, implying that the crystalline structure of GO was converted to GA which contained a large percent of amorphous structure and a smaller crystalline structure formed by stacking layers of graphene. The C/O ratio in GA sample was significantly increased compared to GO samples (6.5/1 compared to 1.38/1), suggesting that oxygen-containing functional groups (-OH, -C=O, -O-…) in GO were drastically reduced. The optimal conditions for the adsorption of TC were 10 mg L-1 TC solution, pH 7.0 at 75 min, 0.1 g L-1 of adsorbent, and at 30 °C. The adsorption process was better described by Langmuir isotherm model (R2=0.9938) compared to Freundlich one (R2=0.1302). The maximum adsorption capacity (Qmax) of GA calculated by the Langmuir model was 107.5 mg g-1, significantly higher than other common adsorbents. GA presented a stable and promising adsorbent for TC removal in water.
Study on the Fluctuations of Typical Glaciers and Lakes in the Tibetan Plateau Using Remote Sensing

Glaciers and lakes on the Tibetan Plateau play an important role in the earth's climatic system.The remote sensing techniques and the Geographic Information System technology is an efficient tool to analyze the status and fluctuations of glaciers and lakes.In this paper,the variations of typical glaciers and lakes throughout the Tibetan Plateau were investigated by analyzing the datasets from aerial photos,satellite images,topographical and the derived digital elevation models during the period of 1960-2000.The results show that variation of lake area depends clearly on local climate change.Over the past 30 years,the most of lakes in the middle Tibetan Plateau,such as the Seling Lake and Nam Lake,expanded and glaciers around the lakes retreated dramatically.It is inferred that the increasing of precipitation,decreasing of potential evaportranspiration and runoff from glacier melting are responsible mainly for the lake expanding.However,the lakes in the head regions of the Yellow River in the northeastern plateau shrunk in the period of 1960-2000 despite of glacier retreating.In the source regions of the Yellow River,the changing trend of precipitation,although positive,is not significant while temperature increased apparently,indicating water loss of the lakes enhanced through increasing of evaportranspiration and thus lakes shrunk in the past 30 years.It is also argued that ecosystem regression resulted from human activity in the regions played an important role in the lake shrinking.
Pain Management During Adult Laparoscopic Appendectomy: A Systematic Review

The opioid epidemic has become a critical public health issue, driven by the widespread distribution and misuse of prescription opioids. This paper investigates analgesic management in the context of laparoscopic appendectomy (LA) as an alternative to open appendectomy, aiming to reduce the reliance on opioids for postoperative pain control. A comprehensive literature review was conducted from January 1, 2003, to November 1, 2023, utilizing PubMed, ProQuest, and ScienceDirect databases. The search focused on peer-reviewed experimental and observational studies involving adults (18 years and older) undergoing LA. The original search resulted in 18,258 publications, which were then screened using PRISMA guidelines. Among the filtered 18 studies included for analysis and review, the transition from open to LA demonstrated a consistent decrease in postoperative pain, leading to a reduced need for opioid prescriptions. Analgesic strategies included the use of local anesthetics (lidocaine, bupivacaine, ropivacaine), spinal/epidural anesthesia, nerve blocks, and a multimodal approach with NSAIDs and acetaminophen. Studies demonstrated the efficacy of local anesthetics in reducing postoperative pain, prompting a shift toward non-opioid analgesics. The use of spinal/epidural anesthesia and nerve blocks further supported the trend of minimizing opioid prescriptions. While some variations in anesthetic approaches existed, overall, patients undergoing LA required fewer opioid doses, reflecting a positive shift in postoperative pain management. Patients undergoing LA experienced lower rates of readmission, reduced post-operative pain, better cosmetic outcomes, and shorter recovery times, contributing to a diminished demand for opioid medications. This review underscores the potential for non-opioid analgesic strategies in surgical contexts, aligning with the broader imperative to address the opioid epidemic and promote safer and more sustainable pain management practices.
An Optimized Ka-Band Low Profile Dual-Polarized Transmitarray Antenna With 2D Beam Switching

This article presents an optimized dual-polarized transmitarray antenna (TA) designed for MIMO applications at the Ka-band, capable of switching beams in two directions. The antenna aperture uses a small unit cell with three layers of Taconic RF-35 dielectric substrates, which can be easily fabricated using PCB technology. The unit cell achieved a 360-degree phase shift and a transmission magnitude exceeding–0.4 dB at 28 GHz. We used nine dual-polarized patch antennas in a cross shape, each with a 10.5 dBi gain at 28 GHz, to switch the beams in two directions without changing the feed location. We optimized the phase distribution in the TA aperture and adjusted the feed antenna’s $F/D$ and tilt to achieve a high-gain antenna with low-gain roll-off during beam switching. The fabricated TA exhibited excellent agreement with the full-wave simulation results. It achieved ±15 degrees and ±30 degrees beam tilts in the x- and y- directions, with less than 0.8 dB gain roll-off for both polarizations.
Metastatic Ovarian Serous Adenocarcinoma Clinically Presenting as Inflammatory Breast Cancer

Metastatic disease to the breast is a rare event, accounting for 0.5-2% of all breast cancers. Outside of metastases from the contralateral breast, malignant ovarian epithelial tumors are the most common origin of these metastases. Here, we present a very rare case of a high-grade ovarian serous adenocarcinoma presenting clinically as inflammatory breast cancer in a 70-year-old woman.
Identity Of Handling Water Pollution Caused By Petroleum Pollution In Indonesia By Adsorption

Indonesia is a maritime country known for its vast territorial waters of sea, reservoirs, rivers, lakes, and bays compared to its land area which makes Indonesia rich in natural resources of sea and other waters. However, many problems are faced when preserving the sea such as marine pollution in the form of petroleum spills which are very dangerous for marine ecosystems. Therefore, there needs to be a handling effort to overcome this. The purpose of this research is to provide information about handling by adsorption to overcome petroleum pollution. The preparation method is carried out by analyzing articles from various literature sources such as journals, scientific papers, report books, and Google Scholar. The conclusion is that the treatment that can be applied to overcome the pollution of the sea and other waters due to petroleum in Indonesia by adsorption using activated carbon cassava peel, cocoa pod skin, water hyacinth, banana peel, and banana stem is classified as effective, efficient and economical management and has its advantages in reducing the levels of parameters contained in petroleum waste.
The IRAK-M death domain: a tale of three surfaces

The anti-inflammatory interleukin-1 receptor associated kinase-M (IRAK-M) is a negative regulator of MyD88/IRAK-4/IRAK-1 signaling. However, IRAK-M has also been reported to activate NF-κB through the MyD88/IRAK-4/IRAK-M myddosome in a MEKK-3 dependent manner. Here we provide support that IRAK-M uses three surfaces of its Death Domain (DD) to activate NF-κB downstream of MyD88/IRAK-4/IRAK-M. Surface 1, with central residue Trp74, binds to MyD88/IRAK-4. Surface 2, with central Lys60, associates with other IRAK-M DDs to form an IRAK-M homotetramer under the MyD88/IRAK-4 scaffold. Surface 3; with central residue Arg97 is located on the opposite side of Trp74 in the IRAK-M DD tetramer, lacks any interaction points with the MyD88/IRAK-4 complex. Although the IRAK-M DD residue Arg97 is not directly involved in the association with MyD88/IRAK-4, Arg97 was responsible for 50% of the NF-κB activation though the MyD88/IRAK-4/IRAK-M myddosome. Arg97 was also found to be pivotal for IRAK-M’s interaction with IRAK-1, and important for IRAK-M’s interaction with TRAF6. Residue Arg97 was responsible for 50% of the NF-κB generated by MyD88/IRAK-4/IRAK-M myddosome in IRAK-1/MEKK3 double knockout cells. By structural modeling we found that the IRAK-M tetramer surface around Arg97 has excellent properties that allow formation of an IRAK-M homo-octamer. This model explains why mutation of Arg97 results in an IRAK-M molecule with increased inhibitory properties: it still binds to myddosome, competing with myddosome IRAK-1 binding, while resulting in less NF-κB formation. The findings further identify the structure-function properties of IRAK-M, which is a potential therapeutic target in inflammatory disease.