Miracle-dz/UniFAR-FTUs huggingface dataset:
Schistosoma mansoni Fibroblast Growth Factor Receptor A Orchestrates Multiple Functions in Schistosome Biology and in the Host-Parasite Interplay

Stem cells play significant roles in driving the complex life cycle of Schistosoma mansoni. Fibroblast growth factor (FGF) receptor A (SmFGFRA) is essential for maintaining the integrity of schistosome stem cells. Using immunolocalization, we demonstrated that SmFGFRA was distributed abundantly in germinal/stem cells of different S. mansoni life stages including eggs, miracidia, cercariae, schistosomula and adult worms. Indeed, SmFGFRA was also localized amply in embryonic cells and in the perinuclear region of immature eggs; von Lichtenberg’s layer and the neural mass of mature eggs; the ciliated surface and neural mass of miracidia; the tegument cytosol of cercariae, schistosomula and adult worms; and was present in abundance in the testis and vitellaria of adult worms of S. mansoni. The distribution pattern of SmFGFRA illustrates the importance of this molecule in maintaining stem cells, development of the nervous and reproductive system of schistosomes, and in the host-parasite interplay. We showed SmFGFRA can bind human FGFs, activating the mitogen activated protein kinase (MAPK) pathway of adult worms in vitro. Inhibition of FGF signaling by the specific tyrosine kinase inhibitor BIBF 1120 significantly reduced egg hatching ability and affected the behavior of miracidia hatched from the treated eggs, emphasizing the importance of FGF signaling in driving the life cycle of S. mansoni. Our findings provide increased understanding of the complex schistosome life cycle and host-parasite interactions, indicating components of the FGF signaling pathway may represent promising targets for developing new interventions against schistosomiasis.
A novel application for DC motor-generator cascade system by changing signal density of digital chaotic oscillator

Presented is a new method for the realization of a chaotic oscillator in a digital environment. First, a two-stroke sampling mathematical regulation is developed for discrete-time oscillator equations to change signal densities of chaotic signals. This proposed mathematical regulation is applied to Lorenz’s chaotic oscillator, which presents a complex dynamical behavior. An application is shown with simulation through a Matlab-Simulink environment with time-dependent density changes of and graphics and phase space graphics that are dependent on different density changes. Further to this, in an experimental study, Lorenz’s chaotic oscillator’s signals with variable density is applied to a DC motor as armature voltage via an 8-bit microcontroller based hardware environment. Chaotic supply voltage is applied to the motor rotor to generate a chaotic angular velocity. Time-dependent density change results of and graphics are obtained and shown on an oscilloscope by converting chaotic rotor angular velocity to electrical signals, through a tacho-generator. The observed results revealed that chaotic signal production with variable density is achieved both in the simulation environment and the experimental environment. Also, it is shown that the proposed program and mathematical equations are feasible in terms of hardware and software implementations.
Bacteria Halotolerant from Karst Sinkholes as a Source of Biosurfactants and Bioemulsifiers

Halotolerant bacteria with biosurfactant (BS) and bioemulsifiers (BE) activity can coexist in Karstic sinkholes with marine influence. Two sinkholes in the Yucatan peninsula were selected to isolate bacteria with BE and BS activity stable in NaCl. The optimal time, the effect of nitrogen and carbon source in the medium, and the conditions (agitation, pH and salinity) for the production of BS and BE compounds in planktonic and sessile (stimulate the formation of biofilms in cell roller) culture were determined. Eighty strains showed the highest emulsification activity (EI24 ≥ 50%) and drop-collapse ≥ 4 mm. 87% of the strains are moderately halotolerant, and 21% bordered the limit of extreme halotolerance. Twenty-four strains maintained or improved their BS and BE activity under salinity conditions at 5% and 10%, being the most active genera Bacillus, Paenibacillus and Lysinibacillus, identified by sequencing of the 16S rRNA gene. The results show that the nitrogen source positively affects the BS and BE activity, regardless of the type of culture. The sessile culture markedly stimulated BS activity with significant differences. However, we did not find a greater influence on the culture conditions. The results suggest that halotolerant bacteria from sinkholes could be implemented in bioremediation and other biotechnological applications.
Why Does Doxycycline Pose a Relatively Low Risk for Promotion of Clostridioides difficile Infection?

Background: Clinical studies suggest that doxycycline poses a low risk for promotion of Clostridioides difficile infection, but the microbiologic explanation for this finding is unclear. Methods: Mice treated with oral doxycycline, oral azithromycin, subcutaneous ceftriaxone, doxycycline plus ceftriaxone, or azithromycin plus ceftriaxone were challenged with 104 colony-forming units of 2 different C. difficile strains on day 2 of 5 of treatment. The concentration of C. difficile was measured in stool 2 and 5 days after challenge. The impact of the treatments on the microbiota was assessed by sequencing. Results: Doxycycline and azithromycin treatment did not promote colonization by either C. difficile strain in comparison to saline controls. Doxycycline treatment significantly reduced ceftriaxone-induced overgrowth of a C. difficile strain with doxycycline minimum-inhibitory concentration (MIC) of 0.06 µg/mL (P<0.01) but not a strain with doxycycline MIC of 48 µg/mL (P>0.05); azithromycin treatment did not reduce ceftriaxone-induced overgrowth of either strain. 16S rRNA amplicon sequencing revealed significantly lower bacterial diversity in the stool of ceftriaxone-treated mice, in comparison to doxycycline-treated and azithromycin-treated mice. Conclusions: These findings suggest that doxycycline may have a low propensity to promote C. difficile colonization because it causes relatively limited alteration of the indigenous microbiota that provide colonization resistance and because it provides inhibitory activity against some C. difficile strains.
Research on Simulation and Performance Optimization of Mach 4 Civil Aircraft Propulsion Concept

Supersonic civil aircraft is of a promising area in the development of future civil transport, and aircraft propulsion system is one of the key issues which determine the success of the aircraft. To get a good conceptual design and performance investigation of the supersonic civil aircraft engine, in this article, a fast, versatile as well as trust-worthy numerical simulation platform was established to analyze the Mach 4 turbine-based combined cycle (TBCC) engine concept so as to be applied to the supersonic civil aircraft. First, a quick and accurate task requirement analysis module was newly established to analyze the mission requirement of the Mach 4 supersonic civil aircraft. Second, the TBCC engine performance simulation model was briefly presented and the number of engines on the supersonic civil aircraft was analyzed, considering single engine inoperative. Third, the Stone model and the DLR method were investigated to estimate the engine jet noise and the NOx emission of the Mach 4 supersonic civil aircraft. Finally, a multiobjective optimization tool made up of a response surface method and a genetic algorithm was developed to optimize the design parameters and the control law of the TBCC engine, in order to make the Mach 4 supersonic civil aircraft engine with better performance, lower noise, and lower emissions. The uniqueness of the developed analysis tool lies in that it affords a numerical simulation platform capable of investigating the task requirement analysis module of the supersonic civil aircraft, engine jet noise prediction model, and the NOx emission prediction model, as well as a multiobjective performance optimization tool, which is beneficial for the conceptual design and performance research of Mach 4 supersonic civil aircraft’s propulsion system.
Knowledge about HIV/AIDS and Attitudes towards Sexuality of Undergraduate Students at a Peruvian University

In Peru, there are some concerning difficulties in ascertaining the situation of sexually transmitted diseases, which makes it even more difficult to prevent and improve this situation. The objective of this article was to inquire what knowledge the students at a Peruvian university have about HIV/AIDS in order to determine the relationship between this knowledge and attitude towards sexuality. This was a cross-sectional study with a non-experimental design, involving a quantitative approach and a correlation measurement. 294 students were included in the study. The data collection technique used was the survey for each study variable with a Cronbach's alpha of . 884 for the first variable and . 704 for the second variable. Spearman's Rho coefficient correlation test was used to contrast the results. Among the results, a significant and reverse correlation was obtained between knowledge about HIV/AIDS and attitudes towards sexuality (r = -.304, p-value = .000). Likewise, only 54.8% of the students were found to have adequate knowledge regarding HIV/AIDS and 75.17% had normal attitude towards sexuality. It has been concluded that the more the adequate knowledge about HIV, the less students present risk-taking attitudes towards sexuality, and given the evidence of risky sexual behaviour in all age groups, as well as a significant number engaging in regular risk sexual behaviour, we suggest that universities implement sex education programs permanently regardless of the academic cycle.
PACk: An Efficient Partition-based Distributed Agglomerative Hierarchical Clustering Algorithm for Deduplication

The Agglomerative Hierarchical Clustering (AHC) algorithm is widely used in real-world applications. As data volumes continue to grow, efficient scale-out techniques for AHC are becoming increasingly important. In this paper, we propose a Partition-based distributed Agglomerative Hierarchical Clustering (PACk) algorithm using novel distance-based partitioning and distance-aware merging techniques. We have developed an efficient implementation of PACk on Spark. Compared to the state-of-the-art distributed AHC algorithm, PACk achieves 2X to 19X (median=9X) speedup across a variety of synthetic and real-world datasets.
THỰC TRẠNG TỰ CHĂM SÓC VÀ NHU CẦU PHỤC HỒI CHỨC NĂNG CỦA NGƯỜI CAO TUỔI TẠI PHƯỜNG VỊ XUYÊN THÀNH PHỐ NAM ĐỊNH NĂM 2021

Mục tiêu nghiên cứu: mô tả thực trạng tự chăm sóc và xác định các yếu tố liên quan đến nhu câu phục hồi chức năng của người cao tuổi. Đối tượng và phương pháp nghiên cứu: nghiên cứu mô tả cắt ngang trên 384 NCT của Phường Vị Xuyên Thành phố Nam Định. Kết quả: về khả năng thực hiện chức năng sinh hoạt hàng ngày: có 52,1% NCT cần sự trợ giúp về ăn uống; 28,4% NCT cần trợ giúp về thay quần áo; 43,5% NCT cần trợ giúp ngồi; 9,1% NCT cần trợ giúp đứng. Ảnh hưởng của giảm khả năng vận động và sinh hoạt lên NCT: 33,1% NCT bị những cảm giác trên làm gián đoạn công việc và 8,1% NCT bị những cảm giác đau khiến không thể ngủ được. Có 49,7% NCT có nhu cầu về PHCN; những người có khó khăn về vận động và những người có khó khăn về hoạt động sinh hoạt hàng ngày có nhu cầu PHCN cao hơn so với những người không với OR lần lượt là 2,16 và 1,24 (p < 0,05). Kết luận: NCT có nguy cơ giảm khả năng về vận động do vậy cần PHCN nhằm giúp giảm bớt những khó khăn trong sinh hoạt hàng ngày và có chất lượng cuộc sống tốt hơn.
On The Current State of Scholarly Retrieval Systems

The enormous growth in the size of scholarly literature makes its retrieval challenging. To address this challenge, researchers and practitioners developed several solutions. These include indexing solutions e.g. ResearchGate, Directory of Open Access Journals (DOAJ), Digital Bibliography & Library Project (DBLP) etc., research paper repositories e.g. arXiv.org, Zenodo, etc., digital libraries, scholarly retrieval systems, e.g., Google Scholar, Microsoft Academic Search, Semantic Scholar etc., digital libraries, and publisher websites. Among these, the scholarly retrieval systems, the main focus of this article, employ efficient information retrieval techniques and other search tactics. However, they are still limited in meeting the user information needs to the fullest. This brief review paper is an attempt to identify the main reasons behind this failure by reporting the current state of scholarly retrieval systems. The findings of this study suggest that the existing scholarly retrieval systems should differentiate scholarly users from ordinary users and identify their needs. Citation network analysis should be made an essential part of the retrieval system to improve the search precision and accuracy. The paper also identifies several research challenges and opportunities that may lead to better scholarly retrieval systems.
Measuring H2O concentrations in olivine by secondary ion mass spectrometry: Challenges and paths forward

Abstract Trace concentrations of H2O in olivine strongly affect diverse mantle and magmatic processes. H2O in olivine has been difficult to accurately quantify due to challenges in sample preparation and measurement, as well as significant uncertainties in standard calibrations. Here we directly compare secondary-ion mass spectrometry (SIMS) measurements of the olivine standards of Bell et al. (2003, hereafter Bell03) and Withers et al. (2012, hereafter Withers12) upon which most SIMS and Fourier transform infrared (FTIR) spectroscopy analyses are based. In the same SIMS session, we find that the olivine standards from the two studies are offset by ~50%, forming lines of different slope when comparing SIMS measurements to the independent nuclear reaction analysis (NRA) in Bell03 and elastic recoil detection analysis (ERDA) in Withers12. This offset is similar to the ~40% offset that exists in the FTIR absorption coefficients determined by those two studies, and points to the NRAERDA data as the cause for the offset more than different IR absorption characteristics of the different olivines. We find that the Withers12 olivine standards form the most precise calibration line, and that the measured Bell03 olivine standards have issues of reproducibility and accuracy due to the presence of hydrous inclusions (as documented previously by Mosenfelder et al. 2011). Owing to the limited availability of the Withers12 olivine standards, however, we recommend using orthopyroxene standards (Kumamoto et al. 2017) to calibrate H2O in olivine by SIMS due to similar calibration slopes. We revise the reference values of current orthopyroxene standards to account for uncertainties in the Bell et al. (1995) manometry data. With these revised values, the orthopyroxene calibration line is within 12% of the Withers12 olivine line, which is within the long-term uncertainty of the SIMS olivine measurements. We apply our SIMS calibration protocol to revise estimates of the partition coefficients for H2O between olivine and melt, resulting in a value of 0.0009 ± 0.0003 at pressures ~0.2–2 GPa. This brings into closer agreement between the partition coefficients determined from experimental studies and those based on natural studies of olivine-hosted melt inclusions.
Isolation and Characterization Cellulose Nanosphere from Different Agricultural By-Products

Cellulose nanospheres (CN) have been considered a leading type of nanomaterial that can be applied as a strengthening material in the production of nanocomposites. This work aimed to isolate and characterize the properties of CN from different agricultural by-products. CNs were successfully isolated from rice straw, corncob, Phulae pineapple leaf and peel using acid hydrolysis (60% H2SO4) combined with homogenization-sonication (homogenized at 12,000 rpm for 6 min and ultrasonicated for 10 min). The results showed that the CN from rice straw (RS-CN) and corncob (CC-CN) exhibited high yields (22.27 and 22.36%) (p < 0.05). All hydrolyzed CNs exhibited a spherical shape with a diameter range of 2 to 127 nm. After acid hydrolysis, Fourier transform infrared (FTIR) results showed no impurities. X-ray diffraction (XRD) showed that the structure of cellulose was changed from cellulose-I to cellulose-II. However, cellulose-I remained in pineapple peel cellulose nanosphere (PP-CN). The crystalline index (CI) ranged from 43.98 to 73.58%, with the highest CI obtained in the CC-CN. The CN from all sources presented excellent thermal stability (above 300 °C). The functional properties, including water absorption Index (WAI), water solubility index (WSI) and swelling capacity were investigated. PP-CN showed the highest WAI and swelling capacity, while the PL-CN had the highest WSI (p < 0.05). Among all samples, CC-CN showed the highest extraction yield, small particle size, high CI, and desirable functional properties to be used as a material for bio-nanocomposites film.
Influence of adhesive type on the flexural behaviour of RC slabs strengthened with NSM-CFRP systems

This work was supported by FEDER funds through the Operational Program for Competitiveness Factors – COMPETE and National Funds through FCT (Portuguese Foundation for Science and Technology) under the project FRPLongDur POCI-01-0145-FEDER-016900 (FCT PTDC/ECM-EST/1282/2014) and partly financed by the project POCI-01-0145-FEDER-007633. Finally, the authors also like to thank the S&P Clever Reinforcement Iberica Lda. company for providing the materials.
Directed Fluidized Bed in Drying Machines: Main Stages of Optimization Calculation

The article deals with the study of main hydrodynamic characteristics of the directed fluidized bed in gravitation shelf dryers. The algorithm to calculate hydrodynamic characteristics of the directed fluidized bed in the dryer’s workspace is described. Every block of algorithm has theoretical model of calculation. Principles of disperse phase motion in various areas in the gravitation shelf dryer are established. The software realization of author’s mathematic model to calculate disperse phase motion trajectory in free and constrained regime, disperse phase residence time in the dryers’s workspace, polydisperse systems classification is proposed in the study. Calculations of disperse phase motion hydrodynamic characteristics using the software product ANSYS CFX, based on the author’s mathematic model, are presented in the article. The software product enables to automatize calculation simultaneously by several optimization criteria and to visualize calculation results in the form of 3D images. The data on the construction of a computational model and computational grid for modeling the gas flow motion is presented. The results of determining the gas flow velocities field in the workspace of a gravitational shelf dryer distinguishing the specific zones of the drying agent’s motion are demonstrated. High and low-intensity places of gas flow are established in the dryer.The residence time of particles in the dryer is calculated depending on the technological and design parameters of the drying process, in particular, the constraint degree of the particle flow. The influence degree of the dryer’s features and its operating mode on the expected “hydrodynamic” residence time of the material in the device is established. The obtained value of the “hydrodynamic” residence time of the material in the device is compared with the drying time to find the optimal design of the dryer.
The release kinetic of drug encapsulated poly(L-lactide-co-ɛ-caprolactone) core-shell nanofibers fabricated by emulsion electrospinning

Abstract Core-shell nanofibers for biomedical applications have been successfully prepared by emulsion electrospinning, utilizing the model drug Tetracycline hydrochloride (TCH) water solution as the “aqueous phase” and hydrophobic polymer solution as the “organic phase. ” The morphology of nanofibers was assessed by scanning electron microscopy (SEM) and the core-shell structure was confirmed by inverted fluorescence microscopy and transmission electron microscopy (TEM). The improved hydrophilicity might be caused by the presence of the emulsifier Span 80 on the surface of the nanofibers. The mechanical properties study showed that core-shell nanofibers membranes were softer and more elastic than blended nanofibers. In vitro drug release study showed that the TCH could release continuously for 34 days. The release mechanism of the nanofibers followed Fickian diffusion at low drug efficiency, but drug diffusion was the best fit with the First-order kinetic model when increasing drug loading rates. Overall, emulsion core-shell nanofibers could be used as a promising drug reservoir for sustained and continuous drug release behaviors. Meanwhile, the study of drug release kinetics was used in conjunction with model drug properties to develop a wider range of nanofibers carriers and biomaterials. GRAPHICAL ABSTRACT
A miniaturized 28 GHz 4‐bit phase shifter in 65 nm LP CMOS for multi‐channel 5‐G radios

A 65 nm LP CMOS 4‐bit phase shifter for 28 GHz 5G applications is presented. Sharing inductor footprints and using a switched inductor allow ~50% of layout size reduction, compared to conventional design. On‐wafer testing shows that the fabricated phase shifter exhibits 14.3 dB average insertion loss over the 27.5–28.35 GHz band. Measured input and output return losses are >7.2 dB. Measured RMS phase and gain error are 9.4° and 2.7 dB at 28 GHz, respectively. Measured input P1dB is >11 dBm. The chip area excluding pads is 0.067 mm2, ×2 more compact than previous Ka‐band phase shifters, to the best of authors' knowledge. The presented phase shifter allows low‐cost IC implementation of multi‐channel 5G transceivers.
Pseudohyperkalemia after total splenectomy in a dog: a case report

A 16-year-old, 7.4 kg, castrated male Cocker Spaniel presenting anorexia and weight loss was referred due to a splenic mass, and total splenectomy was performed to resolve clinical signs. Following surgery, the dog developed mild hyperkalemia (6.27 mmol/L) without any clinical symptoms. Further investigations were conducted to determine the cause of hyperkalemia. The serum-plasma potassium difference was measured (1.05 mmol/L), and pseudohyperkalemia was diagnosed. The cause of pseudohyperkalemia was considered as thrombocytosis after splenectomy. The dog did not receive any specific treatment to lower blood potassium. To our knowledge, we report the first case of post-splenectomy pseudohyperkalemia in a dog.
Assessment of Vegetative Growth and Genetic Integrity of Vanilla planifolia Regenerants after Cryopreservation

Vanilla planifolia Jacks. ex Andrews is the vanilla species with the most commercial and greatest economic importance. It has been used as a case study in different cryopreservation studies that involve three vitrification-based approaches: droplet-vitrification (D-V), V-cryoplate (V-Cp) and D-cryoplate (D-Cp). The aim of this study was to compare the impact of these cryogenic techniques on vegetative growth (survival, stem length and leaf number) between cryo-derived plants and in vitro-derived controls during 12 months of greenhouse growth. Genetic stability was also assessed using the inter-simple sequence repeat (ISSR) markers. There were no significant differences found in the survival and stem lengths of the in vitro-derived regenerants and cryo-derived plants. A significant increase in the number of leaves was only detected in cryo-derived plants when using the V-Cp method. The electrophoretic profiles, based on seven ISSR primers, detected low variability: 81 total bands and 27% polymorphism. This is the first report on the assessment of vegetative growth and genetic integrity in cryo-derived V. planifolia plants recovered under greenhouse conditions. Of the three cryogenic approaches, D-Cp appears to yield V. planifolia regenerants plants with more vigorous vegetative growth and a lower level of polymorphism. Future research should focus on the reproductive growth of vanilla regenerants.