Miracle-dz/UniFAR-FTUs huggingface dataset:
Dexmedetomidine Promotes Alveolar Fluid Clearance by Upregulating Na,K-ATPase Expression in a Rat Model of Acute Lung Injury via α2 AR/PI3K/Akt Pathway

Our previous studies have shown that Dexmedetomidine (Dex), α2 adrenergic receptor (α2AR) agonist, reduces pulmonary edema in LPS-induced acute lung injury (ALI), but the mechanism is not clear. The purpose of this study is to explore whether Dex promotes AFC by upregulating the expression of Na,K-ATPase in LPS-induced ALI and possible molecular mechanisms. Histology of the lungs was assayed with H-E staining, and the lung injury score was calculated. PaO2, PaO2/FiO2 , the lung index, wet/dry (W/D) ratio of the lung tissues and alveolar fluid clearance(AFC) was measured; The concentrations of TNF-α, IL-1β, IL-6 in bronchoalveolar lavage fluid (BALF) and serum were measured. Myeloperoxidase (MPO) activity in lung tissues were determined. The apoptosis rate of A549 cells and the expression of Bcl-2 and Bax were evaluated. The expression of Na,K-ATPase , p-PI3K and p-Akt in vivo and in vitro were evaluated. Dex significantly alleviated lung tissue injury induced by LPS. Dex treatment reduced the W/D, lung index and MPO activity, increased PaO2, PaO2/FiO2 and AFC in LPS-induced ALI. In addition, Dex reduced the concentrations of TNF-α, IL-β and IL-6 in BALF and serum. Dex reduced the apoptosis rate, up-regulated the expression of Bcl-2 and down-regulated the expression of Bax in LPS-stimulated A549 cells. Furthermore, Dex increased the expression of α1Na,K-ATPase, β1 Na,K-ATPase and p-PI3K , p-Akt in vivo and vitro. However, these effects of Dex were partially reversed by the α2AR inhibitor yohim-bine or PI3K inhibitor LY294002. Collectively, these results suggest that Dex attenuates pulmonary edema by stimulating AFC via upregulating the Na,K-ATPase expressi-on in LPS-induced acute lung injury by modulating the α2AR/PI3K/Akt signaling pathway.
Reduction of 4-Ethylphenol and 4-Ethylguaiacol Concentration in Red Wines Using Reverse Osmosis and Adsorption

Excessive concentrations of 4-ethylphenol and 4-ethylguaiacol can spoil red wines. A two-stage integrated process was developed to reduce the concentrations of these compounds in impaired wine. A new approach consisting of a reverse-osmosis housing and a hydrophobic adsorptive resin successfully reduced these volatile phenols to acceptable levels. The resulting wines showed a significant reduction in 4-ethylphenol and 4-ethylguaiacol concentrations, but there was a loss of other aroma compounds. This exploratory work is aimed at improving the aromatic profile of spoiled wine with such a process, which in the future could provide enologists with a powerful tool.
Effect of astaxanthin on the lipid levels of hyperlipidemia rat

Objective To observe the effect of astaxanthin on the lipid level of SD rat by high fat feed.Methods 60 SD male rats were randomized into six groups with 10 rats in each group.They were individually housed in metal cages in an air-conditioned room.Throughout the experimental period,they were given restricted amounts of food(40~50 g/d)per diet,with no limit of drinking.Rats in control group were fed with standard diet,ones in hyperlipidemia model group with standard diet containing cholesterol.Rats in astaxanthin group were fed with standard diet containing cholesterol plus astaxanthin,all lasting for 12 weeks.Blood samples were drawn just before the experiment and at the 4th,8th,12th weekend of the experiment.The blood samples were analyzed for total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) and measured enzymatically by automatic facilities.Results Compared with the hyperlipidemia model group,TC,TG and LDL-C level were lower markedly by dietary astaxanthin at the 12th weekend(P0.01),but HDL-C level was higher than that of the hyperlipidemia model.Conclusions Asaxanthin may effect on the lipid level of rat by high fat feed.
The COVID-19 pandemic in Japan: Its impact on a newborn’s childcare environment and on the mother’s sense of loneliness

Background: The COVID-imposed social isolation of Japanese mothers has significantly increased their already existing sense of loneliness. We report here on the changes that have occurred in the environment of home childcare and in the mother’s feelings of loneliness during the pandemic and we compare these findings with results from a similar previous study we conducted in 2019. Methods: In 2019, we conducted an online survey of mothers who had infants aged 4-12 months. Many of the survey questions at that time concerned the home childcare environment and the mother’s sense of loneliness. In 2020, during the height of this COVID pandemic, we conducted a follow-up COVID impact survey using the same questionnaire, of a different group mothers, again having infants of 4-12 months, to determine the impact of the pandemic on the mothers of extra-vulnerable young children. Results: The number of women who consulted with their friends or neighbors about childcare during the pandemic had decreased from the more normal times of early 2019, whereas in 2020 there was an increase in the number who consulted with their mother. The mother’s method of gathering childrearing information had shifted away from the face-to-face focus of 2019 to a habit of calling a municipal health center or using social-networking-services (SNS) as a reference. The rate was decreased of a mothers’ frequency of interaction with other parents having children at home as old as their own child. Overall, the number of mothers who felt loneliness was significantly increased. Conclusions: Because of the impact on mothers of the COVID pandemic, specifically around their methods of gathering information concerning childcare, we found that the child-rearing 3 environment in Japan has detrimentally changed since early 2019. Whether or not the mother felt stressed or felt they lacked sufficient information concerning childcare was associated with having an impact on the mother’s sense of loneliness. The importance of the appropriate transmission of information concerning childcare had increased due to this pandemic, so we need to take aggressive actions to help these mothers of small children to prevent harm and tragedies from occurring to the children in their care.
The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer’s Disease

During the last years, epigenetic processes have emerged as important factors for many neurodegenerative diseases, such as Alzheimer’s disease (AD). These complex diseases seem to have a heritable component; however, genome-wide association studies failed to identify the genetic loci involved in the etiology. So, how can these changes be transmitted from one generation to the next? Answering this question would allow us to understand how the environment can affect human populations for multiple generations and explain the high prevalence of neurodegenerative diseases, such as AD. This review pays particular attention to the relationship among epigenetics, cognition, and neurodegeneration across generations, deepening the understanding of the relevance of heritability in neurodegenerative diseases. We highlight some recent examples of EI induced by experiences, focusing on their contribution of processes in learning and memory to point out new targets for therapeutic interventions. Here, we first describe the prominent role of epigenetic factors in memory processing. Then, we briefly discuss aspects of EI. Additionally, we summarize evidence of how epigenetic marks inherited by experience and/or environmental stimuli contribute to cognitive status offspring since better knowledge of EI can provide clues in the appearance and development of age-related cognitive decline and AD.
Interprofessionelle Zusammenarbeit im Gesundheitswesen – gemeinsame Ausbildung im Praxisalltag

Im Gesundheitswesen arbeiten verschiedene Berufsgruppen zum Wohl von Patienten zusammen. Das geschieht oft parallel – echtes gemeinsames, interprofessionelles Arbeiten ist nicht die Regel. Interprofessionelle Ausbildung kann zukünftige Arbeitende im Gesundheitswesen auf das Arbeiten im interprofessionellen Team vorbereiten, wie es im immer komplexer werdenden Gesundheitssystem zwingend nötig sein wird.
Global microbial necromass contribution to soil organic matter

Soil organic matter (SOM) plays an important role in mitigating climate change and sustaining soil health and food production 1,2. Mounting evidence suggests that microbial necromass is the main contributor to SOM 3; however, we lack quantification of microbial necromass at a global scale, especially in subsoils. Here, we generate, for the first time, global distribution maps of microbial necromass carbon (C) and nitrogen (N) and contributions to SOM in topsoil and subsoil. Globally, necromass concentrations varied widely across ecosystems and by latitude, contributing 19-60% to SOC and 41-92% to soil N stocks, with particularly large accumulations in boreal and tropical ecosystems. On average, fungal necromass contributions to SOM are 3x greater than bacterial, although this varied across ecosystems. Microbial necromass contributions to SOC are strongly associated with soil C:N ratios and pH; necromass contributions are greater in soils with narrow C:N ratios and higher pH. Microbial necromass is on average 23 and 77 times greater than living microbial biomass in topsoil and subsoil, respectively. These data highlight the importance of necromass contributions to SOM, especially soil N, and the need for spatially resolved necromass data sets that can be used in biogeochemical models to estimate SOM dynamics more accurately.
Effects of Selenium and Vitamin C Supplementation on the Glycemic Markers of Patients with Type II Diabetes: A Randomized Clinical Trial

Introduction:Â Given the global prevalence of diabetes, scientists recommend supplementation with minerals and vitamins to control hyperglycemia in diabetic patients.The present study aimed to investigate the effects of separate and combined selenium and vitamin C supplementation on the glycemic markers of patients with type II diabetes. Â Methods:Â In total, 65 patients with type II diabetes were selected from the patients referring to the Hospital and clinics in Bushehr port, Iran. After matching the samples, the patients were randomly assigned to four groups. The patients in groups one, two, and three respectively received vitamin C (1,000 mg), selenium (100 I¼g), and combined selenium and vitamin C daily and at the same doses for three months. Â In addition, group four received placebo (500 mg). Fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) were measured before and after the intervention. Â Results: In group three, HbA1c and FPG increased significantly compared to the other groups and the control group. Moreover, HbA1c and FPG decreased in groups one and two after the intervention compared to the baseline, which was not considered significant. Â Conclusion:Â According to the results, supplementation with vitamin C and selenium might induce insulin resistance in type II diabetic patients.
Downregulation of AnnexinA5 Gene Expression in Coronary In-Stent Restenosis – A Pilot Study

Background and aims: In- stent restenosis (ISR) is the Achilles heel of angioplasty. AnnexinA5 as an anticoagulant has been shown have anti-inflammatory and anti-atherosclerotic effects. Here we aim to investigating the mRNA expression of AnnexinA5 in peripheral white blood cell of patients with in-stent restenosis. Methods Patients with the history of coronary stent implantation who candidate for re-angiography were entered the study and allocated into two groups according the results of re-angiography; in-stent restenosis (stenosis ≥ 50% in stent) and non-in-stent restenosis (stenosis < 50% in stent). Total RNA of WBC was extracted and cDNA was synthesized using commercial kits. AnnexinA5 expression was assessed with real time PCR and TaqMan probe and reported in relation with GAPDH as a housekeeping gene. Result AnnexinA5 expression was investigated in total 50 participants including 25 ISR and 25 non-ISR. Baseline characteristics including age, sex, smoking habits, hypertension, diabetes mellitus, dyslipidemia and stent in LAD were statistically the same in cases and controls. AnnexinA5 expression in ISR patients was 50% lower than controls. Conclusion AnnexinA5 is down-regulated in ISR and could be considered as a biomarker for predicting ISR and furthermore it could be used as prevention for ISR occurrence.
Preparation of Large-Area Porous Silicon through Cu-Assisted Chemical Etching

Porous silicon (PS) was prepared with catalyst of Cu nanoparticles in HF/H2O2 solutions. The effects of the key fabrication parameters (amount of copper, etching temperature and concentration of H2O2) on the nanostructure of PS were systematically investigated and discussed. The experimental results indicated that the porosity of PS increased with the amount of copper, the reaction temperature and the concentration of H2O2, respectively. Copper can be used as catalyst to assist in etching silicon and the evolution process of copper nanoparticles was explored showing that the mass of copper experienced a drastic reduction in the first 60 seconds. A mechanism is proposed to explain the formation of PS by Cu-assisted chemical etching.
Making a case for the spiritual significance of Dinkho tsa Badimo as sacred ceramics in museum collections

Ceramics as cultural heritage objects have been extensively studied with the main focus being on their functions as vessels used for the transportation, storage, processing and serving of food, and through this study of foodstuffs an exploration of past lifeways, social exchanges and processes. Part of these social processes include beliefs, myths and rituals, particularly those of rulers and chiefs that promote the welfare and wellbeing of a community and assist in social cohesion such as rainmaking. Oftentimes these intangible practices are carried out through tangible conduits such as ceramic vessels, whether to hold potions or mix medicines. Few studies however have focussed their attention on these artefacts, and likewise few have focussed on rituals in domestic settings as used by. In this context, the small ancestral vessel, or Dinkho tsa Badimo, as used by families to engage the ancestors is the focus of the present research. Past museum collection practices could be the cause for this oversight, as these vessels were misidentified, misclassified and incorporated into collections as common household wares, which they resemble. However, highlighting the significance and importance of Dinkho tsa Badimo as a separate class of ceramics, which could be considered ’sacred’, requires particular consideration in curatorial practice informed by appropriate cultural protocols. This article, based on interviews with traditional healers and supplemented with published references seeks to underline the importance of the use of ancestral ceramic vessels in the spiritual practices of Sesotho-Setswana cultural groups of Southern Africa.
Solvent Molecules in Crystalline C60

A set of samples C{sub 60}(cr) was prepared and studied using X-ray diffraction analysis, {sup 1}H NMR, differential scanning calorimetry (DSC), and gas adsorption methods for elucidating the state of residual solvents in C{sub 60}. The solvent molecules were found to be adsorbed at interfaces of the microcrystals of C{sub 60}(cr); sintering of the microcrystals on heating is assumed to be responsible for entrapping some of the solvent molecules in the sample. This may explain the difficulty of removal of the solvents from fullerene samples. The disappearance of the orientational phase transition in DSC curves of mechanically treated samples was interpreted in terms of space defects in the crystals of C{sub 60}.
Risk Factors Contributing to Racial/Ethnic Disparities in Iron Deficiency in US Women

Iron deficiency (ID) in women of reproductive age can negatively impact women's health, pregnancy outcomes and the health and development of their infants. Disparities in rates of iron deficiency by race and ethnicity in the US are persistent, but their causes are not well understood. This study was conducted to describe risk factors for ID and sources of racial/ethnic disparities in ID burden. Adult women ages 20–49 years (N = 1,069) from the National Health and Nutrition Examination Survey 2015–16 who completed the questionnaire and laboratory examinations were included in the analysis. Risk factors for ID (serum ferritin (SF) < 12 µg/L) were examined in three domains: diet (total iron intake, total vitamin C intake, Healthy Eating Index (HEI) score), sociodemographic and acculturation (race/ethnicity, age, place of birth, interview language), and health (BMI, depression symptoms). Prevalence of ID overall and in subgroups were assessed in mean models accounting for the survey design. Associations of risk factors with ID were examined in logistic regression models using survey commands in SAS. In total, 153 women (11.3%) had ID. Prevalence of ID was highest in Mexican American (20.5%, n = 213) and non-Hispanic Black women (19.9%, n = 234) and lower in other Hispanic (13.5%, n = 136) and non-Hispanic, non-Black women (7.7%, n = 486) (p < 0.001). Non-US birth and Spanish language interview were associated with 67% (p = 0.01) and 77% (p = 0.001), respectively, greater risk of ID. Low iron intake and Healthy Eating Index (HEI) were not associated with risk of ID in this sample, while vitamin C intake was inversely associated with risk of ID (β (95% CI): 1.81 (1.0–3.29), p = 0.0. Finally, neither BMI nor depression symptoms was associated with ID in this sample. Stratified and multivariable analyses will be conducted in the 2015–16 and 2017–18 NHANES surveys combined to explore risk factors by race/ethnicity. Sociodemographic and lifestyle characteristics are predictive of ID risk in US women. Planned analyses will generate race/ethnicity-specific risk profiles and identify actionable targets for intervention to reduce racial/ethnic disparities in ID prevalence. None.
Numerical study on mean flow field of turbulent dual offset jet

A numerical investigation on the mean flow and turbulence characteristics of dual offset jet for various separation distances between the two jets with a fixed offset height of the lower jet from the bottom wall is reported in this study. The numerical simulations have been performed by solving the Reynolds-averaged Navier-Stokes equations (RANS) with two-equation standard k − ϵ turbulence model. The Reynolds number based on the jet width and the inlet turbulence intensity are considered as 15,000 and 5%, respectively. The computational results for the mean flow reveal that after issuing from the nozzles, the adjacent shear layers of the offset jets meet together at the merging point and then the merged jets reattaches on the bottom wall at the reattachment point before they combine together at the combined point forming a single jet flow. In the far downstream, the flow field behaves like a classical single wall jet flow. The self-similarity of mean flow field is achieved at far down stream of combined point. An increase in separation distance between the two jets ( d / w ) results in a decrease in magnitude of the streamwise maximum velocity of the combined jet but with same rate of decay. The converging region of the jets has depicted considerable growth of turbulence as the jet centrelines bend towards the merging point. According to the mean flow results, the distances of the reattachment point and the combined point from the nozzle exit gradually increase with the progressive increase in separation distance between the two jets within the range d/w = 3–8.
A Review on Molecular Docking

Molecular docking is computational modeling of structure complexes formed by two or more interacting molecule. The goal of molecular docking is prediction of three dimensional structure of interest. Molecular docking software mostly used in drug improvement. Molecules and effortless entrance to structural databases has befallen essential mechanism. Molecular Docking provide a collection of expensive tools for drug design and analysis. Simple prophecy of molecules and easy way in to structural databases has become essential components on the desktop of the medicinal chemist. The most important application of molecular docking is virtual screening. A variety of docking programs were residential to imagine the three dimensional structure of the molecule and docking gain can also be analyze with the assist of dissimilar computational methods. Molecular docking is a key tool in structural molecular biology and computer-assist drug design. Docking can be worn to execute virtual screening on large libraries of compounds, rank the results, and suggest structural hypotheses of how the ligands reduce the target, which is precious in lead optimization.
Facile construction of novel Ag2O combined TiO2 nanocomposites with enhanced dye degradation under visible-light photocatalytic activity

ABSTRACT The Ag2O/TiO2 composite photocatalysts (PCs) were synthesised in a facile manner into applied photocatalytic decomposition of methylene blue (MB) dye under visible-light treatment. Then, physicochemical belongings of as-fabricated PCs were analytically categorised by powder XRD, FT-IR, HRSEM with an EDXS, HRTEM, UV-Vis DRS and PL spectroscopy. Associated with the pristine TiO2 and Ag2O, the united Ag2O/TiO2 NC exposed greater photo-decomposition actions (~95.4%) in MB dye under visible-light treatment. The photo-degradation rate constant of Ag2O/TiO2 heterostructured composite was about 0.03504 min−1, which is almost 1.8 and 1.2 times superior to pristine TiO2 and Ag2O NPs, individually. Besides, the as-fabricated Ag2O/TiO2 NC exhibits high reutilising stability for the next five consecutive consumptions. Hence it proposes that the liability for strong visible-light fascination capacity, narrow bandgap, effectual separation and hindered the recombination of photo-excited electron-hole (e−/h+) pairs by the construction of greatly dispersed Ag2O NPs.
Impact of electronic word of mouth to the purchase intention - the case of Instagram

This research aims to discover and confirm the factors of e-WOM that influence users' shopping intentions on Instagram. The data was collected from 700 customers who belong to Gen Y and Gen Z from 18 to 39 years old who live and work in Vietnam. The research model and the scales were built from the empirical research of e-WOM from Lim (2016); Park et al. (2007); Prendergast et al. (2010). Quantitative methods were performed by Cronbach's Alpha reliability testing, EFA discovery factor analysis, regression, and ANOVA test. The research results showed that the fourth factor of e-WOM positively impacts users' purchase intent on Instagram with decreasing levels as Information Provider's Expertise, the quantity of e-WOM, and the Source credibility of e-WOM, and the quality of e-WOM, respectively. Also, users' purchase intention on Instagram under the impact of e-WOM varies by gender, but there is no difference by age and income.