Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of Subjective Indicators of Quality of Life in Makurdi

Quality of life measurements are an appropriate means for achieving an understanding of Human needs. This study analyses the quality of life in Makurdi town of Benue state, Nigeria using subjective indices. A sample of 400 respondents was determined based on Taro Yamane formula; and questionnaires were administered on them. The data collected was analysed using descriptive statistics. The result of the study shows that demographically, males and people within the age group of 31-40years and educated people dominated the study area. The result of the study shows that only 1% of the respondents are currently on top of the ladder of quality of life, enjoying the best possible life in the study area. About 74% of the respondent occupied step 5 below. This implies that majority of the people in the study area are currently far from desired quality of life. The study also reveals that in the next five years, about 47% of the people hope to be between steps 6-10 on the quality of life ladder in the study area. This shows an increase of 21% when compare with the current situation in the same range. However, the best possible quality of life in the next five years will remain constant with only 1%. The study reveals that the general well-being of people in Makurdi town on the basis of their experiences of positive, good, pleasant, happiness, joyfulness and contentment is low hence majority of the people have no such experiences but rather the opposite which include negative, bad, unpleasant, sad, angry and discontent. It therefore means that majority of the residents of Makurdi town are in the lower levels on the ladder of quality of life. This study recommends deliberate effort by government and NGOs to provide the basic social amenities and social security packages that will improve people’s quality of life in the town.
Chemical Insights into Topical Agents in Intraocular Pressure Management: From Glaucoma Etiopathology to Therapeutic Approaches

Glaucoma encompasses a group of optic neuropathies characterized by complex and often elusive etiopathology, involvihttng neurodegeneration of the optic nerve in conjunction with abnormal intraocular pressure (IOP). Currently, there is no cure for glaucoma, and treatment strategies primarily aim to halt disease progression by managing IOP. This review delves into the etiopathology, diagnostic methods, and treatment approaches for glaucoma, with a special focus on IOP management. We discuss a range of active pharmaceutical ingredients used in glaucoma therapy, emphasizing their chemical structure, pharmacological action, therapeutic effectiveness, and safety/tolerability profiles. Notably, most of these therapeutic agents are administered as topical formulations, a critical aspect considering patient compliance and drug delivery efficiency. The classes of glaucoma therapeutics covered in this review include prostaglandin analogs, beta blockers, alpha agonists, carbonic anhydrase inhibitors, Rho kinase inhibitors, and miotic (cholinergic) agents. This comprehensive overview highlights the importance of topical administration in glaucoma treatment, offering insights into the current state and future directions of pharmacological management in glaucoma.
Managing Binge Eating Disorder in a Young Adolescent Female: Barriers to Treatment and Recommendations

Binge eating disorder (BED) is a behavioral disorder characterized by chronic and compulsive overeating. It is the most prevalent eating disorder in the USA, affecting almost 3% of the US population. In this study, we describe a case of BED in an adolescent Caucasian female who could not obtain specialized treatment because of financial constraints and saw a child and adolescent psychiatrist for medication management. Her treatment plan combined bupropion with family therapy and resulted in successful alleviation of her symptoms, allowing her to achieve a better quality of life. This case shows how pragmatism by PCPs can help manage patients who cannot obtain specialized care for their BED.
Design and Implementation of an Intelligent Warning Management System for Grinding Based on Deep Forest Overflow Particle Size Prediction

As the main equipment for grinding and classifying minerals in the mineral processing plant, the hydrocyclone's overflow particle size distribution is an important parameter and indicator for measuring working conditions. However, in the harsh environment of actual production, failures occur from time to time and the detection cycle is long. This article uses machine learning methods to achieve online real-time prediction of overflow particle size distribution, and provides a data visualization platform to improve enterprise work efficiency.
Complement in Human Pre-implantation Embryos: Attack and Defense

It is essential for early human life that immunological responses to developing embryos are tightly regulated. An imbalance in the activation and regulation of the human complement system occurs in pregnancy complications, such as pre-eclampsia and recurrent miscarriage. We hereby present the first full analysis of the expression and deposition of complement molecules in human pre-implantation embryos. Thus far, immunological imbalance has been considered in stages of pregnancy following implantation. We here show that complement activation and deposition takes place on developing human embryos already at the pre-implantation stage. Using confocal microscopy, we observed deposition of activation products such as C1q, C3 and C5 on healthy developing embryos, which highlights the need for strict complement regulation. The early embryos express the complement membrane inhibitors CD46, CD55 and CD59 and bind the soluble regulators C4bp and factor H. These findings show that complement targets human embryos, and indicate potential adverse pregnancy outcomes, if regulation of activation fails. In addition, single-cell RNA sequencing of embryos at oocyte, zygote, 4-cell and 8-cell stages showed expression of complement genes, e.g. C1s, C2, C3, C5, factor B and factor D. This shows that the embryonic cells themselves have the capacity to express C3 and C5, which may become activated and function as mediators of cellular signaling. The specific local embryonic expression of complement components, regulators, and deposition of activation products on the surface of embryos suggests that complement has immunoregulatory functions and may impact cellular homeostasis and differentiation at the earliest stage of human life. Statement of significance While canonical functions of the complement system relate to pathogen-defence, it is known to drive certain immune pathologies. The work here described shows, for the first time, expression and localization of a full range of complement molecules in human pre-implantation embryos. We demonstrate complement attack against early embryos, and show presence of embryonic defence mechanisms. Furthermore, we reveal early embryonic production of complement activators, suggesting non-canonical roles in cell signalling and development. Our findings thus reveal a fundamental role for complement at the earliest stages of human embryogenesis. Our data opens up for future studies into the role of complement, both in relation to infertility and pregnancy complications, as well as basic cellular processes during early human development.
Diversidade da macrofauna edáfica em agroflorestas de diferentes estádios sucessionais Soil macrofauna community in the agroforesty of the diferents sucession levels

The conversion of natural ecosystems for systems of agricultural production, causes changes in the community's of the fauna of the soil structure. This study objective was to evaluate the diversity of the soil macrofauna community as indicating of the soil quality in agroforestry systems. The work was developed in the city of Esperantina, state of the Piaui, where had been studied five systems: agroforestry systems with three (SAF3), six (SAF6) and ten years of handling (SAF10), agriculture of cut and burn (ACQ) and an area with native forest (FN). Five litter and soil samples in each system had been collected. The density and the diversity of the macrofauna were available. In the ACQ was observed lower values of the evaluated indices. The SAF had presented higher values of diversity comparing to ACQ and FN, showing the efficiency of the agroforesty handling for the macrofauna.
Carbonate carbon isotope evolution of seawater across the Ediacaran–Cambrian transition: evidence from the Keping area, Tarim Basin, NW China

Abstract Sedimentary rocks from the Ediacaran–Cambrian boundary record important biological, climatic and geotectonic changes during this time. To date, only few geochemical investigations on the upper Ediacaran – upper Cambrian rocks in the Tarim Basin have been carried out. Here, we report high-resolution δ13Ccarb records from the Penglaiba, the Wushi phosphorite and the Dongergou sections from Ediacaran–Cambrian Series 3 in the Keping area of the Tarim Basin. The sections display several obvious δ13Ccarb shifts; δ13Ccarb values increased from 3‰ to 6.7‰ across the Qigebulage Formation. Moreover, a negative δ13Ccarb shift across the Ediacaran–Cambrian boundary is apparent; δ13Ccarb values decreased to a minimum of −9.8‰ in the Wushi phosphorite section (−7.7‰ in Dongergou section and −5.4‰ in Penglaiba section), followed by a positive carbonate carbon isotopic excursion across the Yuertusi Formation into the middle of the overlying Xiaoerbulak Formation. Furthermore, more or less invariable positive δ13Ccarb values characterize the middle and upper Xiaoerbulak Formation. The most negative δ13Ccarb value (−14.3‰) occurred near the base of the Shayilik Formation, which is the absolute minimum value among the studied sections of the Cambrian Series 2 to Cambrian Series 3 transition in the world. The δ13C data from Keping, Tarim Basin are in good agreement with carbon isotope profiles recorded in South China, and these events may reflect the perturbation of the carbon cycle in the Tarim Basin during the Ediacaran–Cambrian and the Cambrian Series 2 – Cambrian Series 3 transitions.
The incidental catch of seabirds by longline fisheries: worldwide review and technical guidelines and mitigation

The content of this report was originally prepared as three separate background papers describing longline fisheries of the world, the nature and extent of incidental catch of seabirds in those fisheries and a description of technical and operational measures that can mitigate such incidental catch. An FAO appointed Technical Working Group (TWG) of experts in the field of fishing technology, seabird biology and fisheries management reviewed the content and decided to compile it into one document. The report, first in general terms, describes the interaction of seabirds with longline fisheries with reference to typical behaviour patterns of seabirds and why and how the incidental longline catch of seabirds has become an international issue. The various longline fisheries (demersal and pelagic) of the world are described with regard to technology and effort. The pelagic fisheries, which mainly target tunas, swordfish and billfishes are operated widely from temperate to tropical waters in all oceans. The most important demersal fisheries are found in the North Atlantic and the North Pacific but a longline fisheries for Patagonian tootfish has been developed in the Southern Ocean over the last few years. Certain longline fisheries result in large numbers of seabirds being hooked on setting lines. The major "problem" fisheries are the demersal fisheries of the Northeast Pacific, North Atlantic, Southern Ocean and the Atlantic coast of South America, and the tuna pelagic fisheries of cool temperate seas in the North Pacific and the Southern Ocean. However, data on the incidental catch of seabirds are lacking for a number of longline fisheries, including the Pacific coast of South America, the Mediterranean Sea and in tropical waters of all oceans. Species of seabirds most commonly taken are the albatrosses and large petrels of the family Procellariidae. A comprehensive number of mitigation measures for reducing the incidental catch of seabirds in longline fisheries has been developed during the past 5-10 years. These are all described in detail in the report. With widespread use of such mitigation measures, a significant reduction in incidental catch of seabirds is achievable at a minimal cost and with much potential financial benefit to longline fisheries.
Pharmaceuticals and Personal Care Products as Emerging Water Contaminants

With the advent of better detection, more micro-contaminants are being found in water. Many of these micro-contaminants come from medical therapies and personal care products. These chemicals are comprised of a wide-range of substances including pharmaceuticals, dietary supplements, veterinary drugs, fragrances, hair care products, body lotions, oral care, and cosmetics. Many of these products enhance our quality of life and in some cases, provide life-saving therapies. But, they come with an environmental cost. Scientific research has found sub-therapeutic levels of many of these chemicals in our waterways and in our finished drinking water, causing concern about the potential environmental and public health impacts associated with very low, chronic exposure. As tailored therapies and personal care products are developed, it is crucial to consider how to control emerging contaminants from medical therapies and personal care products. Specific actions and policies can be implemented now by adopting upstream approaches to prevent waste and decrease environmental exposures.
A Multi-Attention Feature Distillation Neural Network for Lightweight Single Image Super-Resolution

In recent years, remarkable performance improvements have been produced by deep convolutional neural networks (CNN) for single image super-resolution (SISR). Nevertheless, a high proportion of CNN-based SISR models are with quite a few network parameters and high computational complexity for deep or wide architectures. How to more fully utilize deep features to make a balance between model complexity and reconstruction performance is one of the main challenges in this field. To address this problem, on the basis of the well-known information multi-distillation model, a multi-attention feature distillation network termed as MAFDN is developed for lightweight and accurate SISR. Specifically, an effective multi-attention feature distillation block (MAFDB) is designed and used as the basic feature extraction unit in MAFDN. With the help of multi-attention layers including pixel attention, spatial attention, and channel attention, MAFDB uses multiple information distillation branches to learn more discriminative and representative features. Furthermore, MAFDB introduces the depthwise over-parameterized convolutional layer (DO-Conv)-based residual block (OPCRB) to enhance its ability without incurring any parameter and computation increase in the inference stage. The results on commonly used datasets demonstrate that our MAFDN outperforms existing representative lightweight SISR models when taking both reconstruction performance and model complexity into consideration. For example, for ×4 SR on Set5, MAFDN (597K/33.79G) obtains 0.21 dB/0.0037 and 0.10 dB/0.0015 PSNR/SSIM gains over the attention-based SR model AFAN (692K/50.90G) and the feature distillation-based SR model DDistill-SR (675K/32.83G), respectively.
Evaluating alternative macroinvertebrate sampling methodologies in wetlands: Influence of sieve mesh size on relationships between environmental and assemblage variables

By definition, a macroinvertebrate is any invertebrate that is large enough to be retained on a 500-μm mesh sieve. Although macroinvertebrates (hereafter invertebrates) are important in food webs and sensitive to environmental conditions, they are often omitted from wetland condition monitoring programs because use of this fine-mesh sieve makes sample collection and processing time consuming and expensive. The objective of this study was to identify a more cost-effective approach for obtaining invertebrate-based data that can be used to evaluate wetland condition. In 2014 and 2015, invertebrates and associated particulate matter (PM; living and dead plants, sediment) were collected from 27 wetlands in the Iowa Prairie Pothole Region using a stovepipe sampler. Sample material retained on a 500-μm mesh sieve was preserved. In the laboratory, samples were washed through a series of sieves that separated invertebrates and particulate matter into four size fractions. The 6-mm fraction included material retained on the 6-mm sieve, the 4-mm fraction included material retained on both 4and 6-mm sieves, the 2-mm size fraction included material retained on 2-, 4-, and 6-mm sieves, and the 500-μm fraction was the sum total of material retained on 2-, 4-, 6-, and 500-μm sieves (i.e., the entire sample). Volume of each sample size fraction and time required to separate invertebrates from PM were recorded. Invertebrates were identified to family (mollusks, insects, isopods), order (amphipods, decapods), or class (annelids), and numbers of individuals were recorded. Subsequently, invertebrates were again washed through the sieve column in the absence of PM, and organisms in each size fraction were identified and counted. Values for invertebrate numerical density and taxon richness variables were quantified for each of the four invertebrate size fractions and when PM was present (+ PM) and absent (PM). Invertebrate assemblage variables were related to environmental variables indicative of wetland condition (e.g., turbidity, chloride concentration,
A Simple and Efficient CRISPR Technique for Protein Tagging

Genetic knock-in using homology directed repair is an inefficient process, requiring selection of few modified cells and hindering its application to primary cells. Here we describe Homology independent gene Tagging (HiTag), a method to tag a protein of interest by CRISPR in up to 66% transfected cells with one single electroporation. The technique has proven effective in various cell types, can be used to knock in a fluorescent protein for live cell imaging, to modify the cellular location of a target protein and to monitor levels of a protein of interest by a luciferase assay in primary cells.
Bubble-Mediated Production of Few-Layer Graphene via Vapor–Liquid Reaction between Carbon Dioxide and Magnesium Melt

It is urgent to develop novel technologies to convert carbon dioxide to graphene. In this work, a bubble-mediated approach via a chemical reaction between carbon dioxide gas and magnesium melt to fabricate a few-layer graphene was illustrated. The morphology and defects of graphene can be regulated by manipulating the melt temperature. The preparation of graphene at 720 °C exhibited an excellent quality of surface and graphitization degree. The high-quality few-layer graphene can be grown under the combined effect of carbon dioxide bubbles and in-situ grown MgO. This preparation method possesses the advantages of high efficiency, low cost, and environmental protection, which may provide a new strategy for the recovery and reuse of greenhouse gases.
An evaluation of tick and Lyme disease information on health unit websites in Ontario

Climate change has allowed for the expansion and intensification of blacklegged ticks; the vector of Lyme disease. Projections estimate that by the year 2049 all health units in Ontario will have suitable environmental conditions for the establishment of this vector. A review of website content from health units in Ontario was performed to assess the quality of tick and Lyme disease information provided to the public and health care providers. Websites were evaluated based on criteria such as the provision of Lyme disease information (i.e., transmission, symptoms, treatment, etc.), the inclusion of misleading or incorrect information, and visuals provided. The quality of textual and visual information varied substantially across the 35 health units analyzed. Eleven health units were found to provide misleading or incorrect information. Disparities were found between areas with current Lyme disease risk and those without. The majority of health units did not include satisfactory visual content pertaining to ticks. Given the expected expansion and intensification of blacklegged tick populations across the province, all health units must ensure the information communicated to the public about ticks and Lyme disease is of high-quality and consistent. We conclude with specific recommendations to improve the textual and visual content of websites.
In-Depth Analysis of Transistor Influence on OxRAM Performance in Memory Bitcell, With Technology Scaling Perspectives

An oxide-based random access memory (OxRAM) coupled with a MOSFET selector is widely used in memory bitcell for ReRAM technology, but the consequences of the choice of the selector parameters on the reliability are not fully understood yet. This work has the aim to provide new insights on this topic with a specific focus on scaling perspectives. Accordingly, we go through the characterization of different one-transistor one-resistor (1T1R) structures embedding the same OxRAM and selectors of different sizes where the implication of the selector in set and reset operations is separately analyzed. The set current compliance is found to be the most important metric to control the low-resistive state. The reset analysis demonstrates that the OxRAM will always switch at the same bias independently of the selector once the transistor contribution is compensated. Endurance analysis reveals that an excess of reset bias degrades the cyclability of the system. Thus, we asset that in terms of scaling, the right balance between the transistor properties and the programming conditions have to be taken into account.
Analyzing Impacts of SRAM, FF and Combinational Circuit on Chip-Level Neutron-Induced Soft Error Rate

Soft error jeopardizes the reliability of semiconductor devices, especially those working at low voltage. In recent years, silicon-onthin-box (SOTB), which is a FD-SOI device, is drawing attention since it is suitable for ultra-low-voltage operation. This work evaluates the contributions of SRAM, FF and combinational circuit to chip-level soft error rate (SER) based on irradiation test results. For this evaluation, this work performed neutron irradiation test for characterizing single event transient (SET) rate of SOTB and bulk circuits at 0.5 V. Using the SBU and MCU data in SRAMs from previous work, we calculated the MBU rate with/without error correcting code (ECC) and with 1/2/4-col MUX interleaving. Combining FF error rates reported in literature, we estimated chiplevel SER and each contribution to chip-level SER for embedded and highperformance processors. For both the processors, without ECC, 95% errors occur at SRAM in both SOTB and bulk chips at 0.5 V and 1.0 V, and the overall chip-level SERs of the assumed SOTB chip at 0.5 V is at least 10 x lower than that of bulk chip. On the other hand, when ECC is applied to SRAM in the SOTB chip, SEUs occurring at FFs are dominant in the high-performance processor while MBUs at SRAMs are not negligible in the bulk embedded chips. key words: soft error rate, chip-level, SRAMs, flip flops, combinational circuits
Coastal Mass Tourism Diversification And Sustainable Development In Southern Europe

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