Miracle-dz/UniFAR-FTUs huggingface dataset:
A new classification option for NSAID hypersensitivity: Kalyoncu classification.

BACKGROUND The European Network for Drug Allergy (ENDA) proposed a consensus document for hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) in 2011. A subgroup of patients with NSAIDs-exacerbated respiratory disease (NERD) develop urticaria/angioedema type reactions in response to NSAIDs. The Kalyoncu classification might be a novel option to classify patients with NSAID hypersensitivity (NH). In this study, we compare the ENDA and the Kalyoncu classifications. METHODS This study enrolled a total of 196 patients. NH reaction types were categorized as asthma, rhinitis, urticaria/angioedema and anaphylaxis. Based on the reaction history and oral provocation test findings, patients were grouped according to ENDA and Kalyoncu classifications. RESULTS The mean age of the 196 patients was 40.32±13.28 years, and 130 (66.3%) of them were female. Under the ENDA and Kalyoncu classifications, the most common NH subgroups were NERD (32%), and isolated NH (34.2%), the least prevalent NH subgroups were single NSAID-induced delayed reactions (SNIDR) (1.5%), and pseudo Samter's syndrome (11.7%). CONCLUSIONS Our research revealed that the Kalyoncu classification is more descriptive of patients with NERD exhibiting urticaria/angioedema-type reactions. It also provides future risk assessment for development of NERD. For controversial cases, the Kalyoncu classification can be utilized as a new complimentary option alone or in conjunction with ENDA classification.
The BRCT Domain from the Homologue of the Oncogene PES1 in Leishmania major (LmjPES) Promotes Malignancy and Drug Resistance in Mammalian Cells

Around 15% of cancer cases are attributable to infectious agents. Epidemiological studies suggest that an association between leishmaniasis and cancer does exist. Recently, the homologue of PES1 in Leishmania major (LmjPES) was described to be involved in parasite infectivity. Mammalian PES1 protein has been implicated in cellular processes like cell cycle regulation. Its BRCT domain has been identified as a key factor in DNA damage-responsive checkpoints. This work aimed to elucidate the hypothetical oncogenic implication of BRCT domain from LmjPES in host cells. We generated a lentivirus carrying this BRCT domain sequence (lentiBRCT) and a lentivirus expressing the luciferase protein (lentiLuc), as control. Then, HEK293T and NIH/3T3 mammalian cells were infected with these lentiviruses. We observed that the expression of BRCT domain from LmjPES conferred to mammal cells in vitro a greater replication rate and higher survival. In in vivo experiments, we observed faster tumor growth in mice inoculated with lentiBRCT respect to lentiLuc HEK293T infected cells. Moreover, the lentiBRCT infected cells were less sensitive to the genotoxic drugs. Accordingly, gene expression profiling analysis revealed that BRCT domain from LmjPES protein altered the expression of proliferation- (DTX3L, CPA4, BHLHE41, BMP2, DHRS2, S100A1 and PARP9), survival- (BMP2 and CARD9) and chemoresistance-related genes (DPYD, Dok3, DTX3L, PARP9 and DHRS2). Altogether, our results reinforced the idea that in eukaryotes, horizontal gene transfer might be also achieved by parasitism like Leishmania infection driving therefore to some crucial biological changes such as proliferation and drug resistance.
Effective potential at three loops

I present the effective potential at three-loop order for a general renormalizable theory, using the \MSbar renormalization scheme and Landau gauge fixing. As applications and illustrative points of reference, the results are specialized to the supersymmetric Wess-Zumino model and to the Standard Model. In each case, renormalization group scale invariance provides a consistency check. In the Wess-Zumino model, the required vanishing of the minimum vacuum energy yields an additional check. For the Standard Model, I carry out the resummation of Goldstone boson contributions, which provides yet more opportunities for non-trivial checks, and obtain the minimization condition for the Higgs vacuum expectation value at full three-loop order. An infrared divergence due to doubled photon propagators appears in the three-loop Standard Model effective potential, but it does not affect the minimization condition or physical observables and can be eliminated by resummation.
Mucormycosis-related osteomyelitis of the maxilla in a post-COVID-19 patient

Mucormycosis is a rare, invasive fungal infection that progresses aggressively and requires prompt surgery and appropriate treatment. The number of cases of mucormycosis in coronavirus disease 2019 (COVID-19) patients has recently increased, and patients with uncontrolled diabetes mellitus are particularly at an elevated risk of infection. This report presents a case of mucormycosis-related osteomyelitis of the maxilla in a 37-year-old man with diabetes mellitus. The patient complained of severe and persistent pain in the right maxilla, accompanied by increased tooth mobility and headache. On contrast-enhanced computed tomographic images, gas-forming osteomyelitis of the right maxilla was observed. Destruction of the maxilla and palatine bone then proceeded aggressively. Sequestrectomy was performed on the right maxilla, and the histopathological diagnosis was mucormycosis. Further investigation after the first operation revealed the patient's history of COVID-19 infection.
Prevalence and Associated Risk Factors of Vestibular Dysfunction in Females with Menopause

Background: Hormonal changes during menopause affect the vestibular system by interfering with homeostasis and by disrupting the enzyme cycles and neurotransmitter function. It has been observed that females have a higher risk of falling and this may increase after menopause. Balance in women is significantly affected by menopause. Objective: To find the prevalence of vestibular dysfunction in menopausal females and to find the risk factors associated with vestibular dysfunction. Methods: The analytical cross-sectional study was conducted from May to October 2021, the data was collected from 385 women in district Jhelum who had menopause after the age of 45 years. Non-probability convenient sampling was used to collect data. The Berg balance scale, activity-specific balance confidence scale, and a self-made questionnaire for risk factors were used in the study. Results: According to the activity-specific balance confidence scale, 24.4% of the population had high, 60.5% moderate, and 15.1% low physical functioning. A score of less than 67% indicated that 48.1% of patients had a risk for falls in the future. Berg balance scale showed that 6.8% of patients had a high, 22.9% medium, and 60.4% low risk of falling, a score less than 45 demonstrated that 55.8% had a higher fall risk. Diabetes, hypertension, heart disease, and smoking were all statistically significant risk factors for falls (p≤0.001). Conclusion: The current study concludes that there is a significant risk of developing vestibular dysfunction, with an increased risk of falls after menopause in females. Hearing loss is the most common risk factor while obesity also has a great impact on the vestibular system. But there is an increased chance of falls in participants with stroke and hypertension.
How double dynamics affects the large deformation and fracture behaviors of soft materials

Numerous mechanically strong and tough soft materials comprising of polymer networks have been developed over the last two decades, motivated by new high-tech applications in engineering and bio-related fields. These materials are characterized by their dynamic complexities and large deformation behaviors. In this Review, we focus on how chain dynamics affects the large deformation and fracture behaviors of soft materials. To favor readers without a rheology background, first we review the linear rheology behaviors of several simple networks. We show that, by playing with the physical entanglement, chemical cross-linking, and physical association of the building polymers, a very rich panel of dynamic responses can be obtained. Then, we show examples of how chain dynamics affects the deformation and fracture behaviors of dually cross-linked hydrogels having chemical cross-linkers and physical bonds. We also provide examples on the unique deformation behavior of physical double-network gels made from triblock polymers. Thereafter, examples of the influence of chain dynamics on the crack initiation and growth behaviors are presented. We show that even for chemically cross-linked double-network hydrogels that exhibit elastic behaviors in a common deformation window, the chain dynamics influences the damage zone size at the crack tip. Finally, we conclude this Review by proposing several directions for future research.
H i in Virgo’s “Red and Dead” Dwarf Ellipticals—A Tidal Tail and Central Star Formation

We investigate a sample of three dwarf elliptical galaxies in the Virgo Cluster that have significant reservoirs of H i. We present deep optical imaging (from CFHT and KPNO), H i spectra (Arecibo), and resolved H i imaging (VLA) of this sample. These observations confirm their H i content and optical morphologies, and indicate that the gas is unlikely to be recently accreted. The sample has more in common with dwarf transitionals, though dwarf transitionals are generally lower in stellar mass and gas fraction. VCC 190 has an H i tidal tail from a recent encounter with the massive spiral galaxy NGC 4224. In VCC 611, blue star-forming features are observed that were not seen by shallower SDSS imaging.
Suicidality as a Predictor of Overdose among Patients with Substance Use Disorders

Increasing rates of overdose and overdose deaths are a significant public health problem. Research has examined co-occurring mental health conditions, including suicidality, as a risk factor for intentional and unintentional overdose among individuals with substance use disorder (SUD). However, this research has been limited to single site studies of self-reported outcomes. The current research evaluated suicidality as a predictor of overdose events in 2541 participants who use substances enrolled across eight multi-site clinical trials completed within the National Drug Abuse Treatment Clinical Trials Network between 2012 to 2021. The trials assessed baseline suicidality with the Concise Health Risk Tracking Self-Report (CHRT-SR). Overdose events were determined by reports of adverse events, cause of death, or hospitalization due to substance overdose, and verified through a rigorous adjudication process. Multivariate logistic regression was performed to assess continuous CHRT-SR score as a predictor of overdose, controlling for covariates. CHRT-SR score was associated with overdose events (p = 0.03) during the trial; the likelihood of overdose increased as continuous CHRT score increased (OR 1.02). Participants with lifetime heroin use were more likely to overdose (OR 3.08). Response to the marked rise in overdose deaths should integrate suicide risk reduction as part of prevention strategies.
X-ray Reverberation Observational Modelling in Active Galactic Nuclei

X-ray reverberation in Active Galactic Nuclei, believed to be the result of the reprocessing of coronal photons by the underlying accretion disc, has allowed us to probe the properties of the inner-most regions of the accretion flow and the central black hole. Our current model (KYNREFREV) computes the time-dependent reflection spectra of the disc as a response to a flash of primary power-law radiation from a point source corona located on the axis of the black hole accretion disc (lamp-post geometry). Full relativistic effects are taken into account. The ionization of the disc is set for each radius according to the amount of the incident primary flux and the density of the accretion disc. We detect wavy residuals around the best-fit reverberation model time lags at high frequencies. This result suggests that the simple lamp-post geometry does not fully explain the X-ray source/disc configuration in Active Galactic Nuclei. There has been a noticeable progress into the development of codes for extended coronae (Wilkins+16, Chainakun & Young 2017, Taylor & Reynolds 2018a,b). Indeed, the model from Chainakun & Young (2017), consisting of two axial point sources illuminating an accretion disc that produce the reverberation lags is able to reproduce the observed time-lag versus frequency spectra. The goal of this paper is to observationally justify the need for an extended corona in order to provide (in the near future) with a mathematical formulation of a model for an extended corona in its simplest form.
Theoretical X-Ray Absorption Debye-Waller Factors

An approach is presented for theoretical calculations of the Debye-Waller factors in x-ray absorption spectra. These factors are represented in terms of the cumulant expansion up to third order. They account respectively for the net thermal expansion � (1) (T), the mean-square relative displacements � 2 (T), and the asymmetry of the pair distribution function � (3) (T). Similarly, we obtain Debye-Waller factors for x-ray and neutron scattering in terms of the mean-square vibrational amplitudes u 2 (T). Our method is based on density functional theory calculations of the dynamical matrix, together with an efficient Lanczos algorithm for projected phonon spectra within the quasiharmonic approximation. Due to anharmonicity in the interatomic forces, the results are highly sensitive to variations in the equilibrium lattice constants, and hence to the choice of exchangecorrelation potential. In order to treat this sensitivity, we introduce two prescriptions: one based on the local density approximation, and a second based on a modified generalized gradient approximation. Illustrative results for the leading cumulants are presented for several materials and compared with experiment and with correlated Einstein and Debye models. We also obtain Born-von Karman parameters and corrections due to perpendicular vibrations.
Noncollinearity-modulated Electronic Properties of Monolayer 
CrI3

The use of two-dimensional materials could thin down electronic devices to atomic layers, a regime where the precise control of electronic transport becomes a great challenge. A single layer of the ferromagnetic semiconductor CrI${}_{3}$ has an electronic structure that is significantly modulated by noncollinear magnetization. By introducing a ferromagnetic domain wall, a one-dimensional conduction channel just a few nanometers wide can be formed in the insulating monolayer. These conducting wires can be spatially relocated, ``rewritten'', by applying a magnetic field or injecting spin waves, suggesting reprogrammable electronic nanodevices.
Implementation of binder-free SnO2 NWs@C electrode and LiTFSI-based electrolyte for high-performance lithium-ion battery

This study has investigated the effect of carbon coating on the electrochemical performance of SnO2 Nanowires (NWs) as an electrode along with a bis (trifluoromethane) sulfonimide lithium (LiTFSI)-based electrolyte in a lithium-ion battery (LIB). The vapor–liquid–solid approach has been used to grow SnO2 NWs on the stainless steel mesh current collector. The obtained results have demonstrated that the utilization of the LiTFSI-based electrolyte improved the battery performance with the SnO2 NWs electrode over the LiPF6-based electrolyte. This may be due to the formation of a stable and thin solid electrolyte interphase layer. Since bare SnO2 NWs exhibit inferior cycling stability due to their high volumetric expansion and poor conductivity, incorporating carbon coating could improve performance. Although the initial discharge specific capacity obtained for the carbon-coated SnO2 NWs (SnO2 NWs@C) electrode (1328.4 mAh g−1) was in the order of the first discharge capacity for the SnO2 NWs, the SnO2 NWs@C electrode possessed capacity retention with six times improvement as compared to the pristine SnO2 NWs after 120 cycles. The Coulombic efficiency of 99% has been achieved for the SnO2 NWs@C electrode over 120 cycles. Field emission scanning electron microscopy images revealed that the carbon coating could keep the overall structure of the electrode upon cycling. It has been evidenced that the SnO2 NWs@C electrode with LiTFSI-based electrolyte has an excellent potential to implement in high-performance LIBs.
Wideband on-chip terahertz spectrometer based on a superconducting filterbank

Abstract. Terahertz spectrometers with a wide instantaneous frequency coverage for passive remote sensing are enormously attractive for many terahertz applications, such as astronomy, atmospheric science, and security. Here we demonstrate a wide-band terahertz spectrometer based on a single superconducting chip. The chip consists of an antenna coupled to a transmission line filterbank, with a microwave kinetic inductance detector behind each filter. Using frequency division multiplexing, all detectors are read-out simultaneously, creating a wide-band spectrometer with an instantaneous bandwidth of 45 GHz centered around 350 GHz. The spectrometer has a spectral resolution of F / ΔF = 380 and reaches photon-noise limited sensitivity. We discuss the chip design and fabrication, as well as the system integration and testing. We confirm full system operation by the detection of an emission line spectrum of methanol gas. The proposed concept allows for spectroscopic radiation detection over large bandwidths and resolutions up to F / ΔF ∼ 1000, all using a chip area of a few cm2. This will allow the construction of medium resolution imaging spectrometers with unprecedented speed and sensitivity.
On the Sensitivity of Magnetic Cycles in Global Simulations of Solar-like Stars

The periods of magnetic activity cycles in the Sun and solar-type stars do not exhibit a simple or even single trend with respect to rotation rate or luminosity. Dynamo models can be used to interpret this diversity and can ultimately help us understand why some solar-like stars do not exhibit a magnetic cycle, whereas some do, and for the latter what physical mechanisms set their magnetic cycle period. Three-dimensional nonlinear MHD simulations present the advantage of having only a small number of tunable parameters, and produce in a dynamically self-consistent manner the flows and the dynamo magnetic fields pervading stellar interiors. We conduct a series of such simulations within the EULAG-MHD framework, varying the rotation rate and luminosity of the modeled solar-like convective envelopes. We find decadal magnetic cycles when the Rossby number near the base of the convection zone is moderate (typically between 0.25 and 1). Secondary, shorter cycles located at the top of the convective envelope close to the equator are also observed in our numerical experiments, when the local Rossby number is lower than 1. The deep-seated dynamo sustained in these numerical experiments is fundamentally nonlinear, in that it is the feedback of the large-scale magnetic field on the large-scale differential rotation that sets the magnetic cycle period. The cycle period is found to decrease with the Rossby number, which offers an alternative theoretical explanation to the variety of activity cycles observed in solar-like stars.
Metabolic Implications of Antiepileptic Therapy Among Children with Epilepsy

An important consideration within the side effects profile of antiseizure medications (ASM) is the impact of these medications on metabolic parameters. Scientific literature is replete with descriptions of the adverse metabolic profile of the older or first and second generation ASMs, such as carbamazepine, valproate, phenytoin, phenobarbitone, and to a lesser extent, among the newer ASMs. [1] ASMs, particularly enzymeinducing drugs, can precipitate early atherosclerosis. However, in resource-limited settings such as India, these older medications continue to maintain a stronghold in the epilepsy therapeutic armamentarium due to their affordability and wide availability. Hence, epilepsy practitioners in our settings must be aware of these metabolic effects.
The little dippers: transits of star-grazing exocomets?

We describe EPIC 205718330 and EPIC 235240266, two systems identified in the K2 data whose light curves contain episodic drops in brightness with shapes and durations similar to those of the young `dipper' stars, yet shallower by ˜1-2 orders of magnitude. These `little dippers' have diverse profile shapes with durations of ≃0.5-1.0 d and depths of ≃0.1-1.0 per cent in flux; however, unlike most of the young dipper stars, these do not exhibit any detectable infrared excess indicative of protoplanetary discs, and our ground-based follow-up spectra lack any signatures of youth while indicating that these objects are kinematically old. After ruling out instrumental and/or data processing artefacts as sources of the dimming events, we investigate possible astrophysical mechanisms based on the light curve and stellar properties. We argue that the little dippers are consistent with transits of star-grazing exocomets, and speculate that they are signposts of massive non-transiting exoplanets driving the close-approach orbits.
Mirror symmetry and Landau–Ginzburg Calabi–Yau superpotentials in F-theory compactifications

We study the Landau–Ginzburg (LG) theory mirror to two-dimensional (2D) N = 2 gauged linear sigma models on toric Calabi–Yau manifolds. We derive and solve new constraint equations for LG elliptic Calabi–Yau superpotentials depending on the physical data of dual linear sigma models. In the Calabi–Yau threefold case, we consider two examples. First, we give the mirror symmetry of the canonical line bundle over the Hirzebruch surfaces Fn. Second, we find a special geometry with the affine so(8) Lie algebra toric data extending the geometry of elliptically fibred K3. This geometry leads to a pure N = 1 six-dimensional SO(8) gauge model from the F-theory compactification. For Calabi–Yau fourfolds, we give a new algebraic realization for ADE hypersurfaces.
Discrete cosmological models in the Brans–Dicke theory of gravity

We consider the problem of building inhomogeneous cosmological models in scalar-tensor theories of gravity. This starts by splitting the field equations of these theories into constraint and evolution equations, and then proceeds by identifying exact solutions to the constraints. We find exact, closed form expressions for geometries that correspond to the initial data for cosmological models containing regular arrays of point-like masses. These solutions extend similar methods that have recently been applied to Einstein’s equations, and provides sufficient initial conditions to perform numerical integration of the evolution equations. We use our new solutions to study the effects of inhomogeneity in cosmologies governed by scalar-tensor theories of gravity, including the spatial inhomogeneity allowed in Newton’s constant. Finally, we compare our solutions to their general relativistic counterparts, and investigate the effect of changing the coupling constant between the scalar and tensor degrees of freedom.