Miracle-dz/UniFAR-FTUs huggingface dataset:
Flexible Endoscopy With Non-invasive Ventilation Enables Clinicians to Assess and Manage Infants With Severe Bronchopulmonary Dysplasia

Objectives The objectives of the study were to determine the efficacy of flexible endoscopy (FE) to assess the approachable aeroesophageal tract (AET) and subsequent changes in clinical management in infants with severe bronchopulmonary dysplasia (sBPD). Methods This retrospective study investigated sBPD infants who received FE measurement from 2011 to 2020. FE was supported with non-invasive ventilation (FE-NIV) of pharyngeal oxygen with nose closure and abdominal compression without any mask or laryngeal mask airway. Data on AET lesions, changes in subsequent management, and FE therapeutic interventions were collected and analyzed. Results Forty-two infants were enrolled in the study. Two thin scopes (1.8- and 2.6-mm outer diameter) were used. FE analysis revealed 129 AET lesions in 38 (90.5%) infants. Twenty-eight infants (66.7%) had more than one lesion. Thirty-five (83.3%) infants had 111 airway lesions where bronchial granulations (28, 25.2%), tracheomalacia (18, 16.2%), and bronchomalacia (15, 13.5%) were the main complications. Eighteen esophageal lesions were found in 15 (35.7%) infants. No significant FE-NIV complications were observed. The FE findings resulted in changes in management in all 38 infants. Thirty-six (85.7%) infants underwent altered respiratory care with pressure titrations (29, 45.3%), shortened suction depth (17, 26.6%), immediate extubation (8, 12.5%), changed insertion depth of endotracheal tube (7, 10.9%) and tracheostomy tube (3, 4.7%). Twenty-one (50%) infants had 50 pharmacotherapy changes, including added steroids, anti-reflux medicine, antibiotics, and stopped antibiotics. Eighteen (42.8%) infants received 37 therapeutic FE-NIV procedures, including 14 balloon dilatations, 13 laser-plasty, and 10 stent implantations. Seven (16.7%) infants underwent surgeries for four tracheostomies and three fundoplications. Conclusion Flexible endoscopy with this non-invasive ventilation could be a safe and valuable technique for direct and dynamic visual measurement of AET, which is essential for subsequent medical decision making and management in infants with sBPD.
Variable and Conserved Regions of Secondary Structure in the β-Trefoil Fold: Structure Versus Function

β-trefoil proteins exhibit an approximate C3 rotational symmetry. An analysis of the secondary structure for members of this diverse superfamily of proteins indicates that it is comprised of remarkably conserved β-strands and highly-divergent turn regions. A fundamental “minimal” architecture can be identified that is devoid of heterogenous and extended turn regions, and is conserved among all family members. Conversely, the different functional families of β-trefoils can potentially be identified by their unique turn patterns (or turn “signature”). Such analyses provide clues as to the evolution of the β-trefoil family, suggesting a folding/stability role for the β-strands and a functional role for turn regions. This viewpoint can also guide de novo protein design of β-trefoil proteins having novel functionality.
Interactome and Ubiquitinome Analyses Identify Functional Targets of Herpes Simplex Virus 1 Infected Cell Protein 0

Herpes simplex virus 1 (HSV-1) can productively infect multiple cell types and establish latent infection in neurons. Infected cell protein 0 (ICP0) is an HSV-1 E3 ubiquitin ligase crucial for productive infection and reactivation from latency. However, our knowledge about its targets especially in neuronal cells is limited. We confirmed that, like in non-neuronal cells, ICP0-null virus exhibited major replication defects in primary mouse neurons and Neuro-2a cells. We identified many ICP0-interacting proteins in Neuro-2a cells, 293T cells, and human foreskin fibroblasts by mass spectrometry–based interactome analysis. Co-immunoprecipitation assays validated ICP0 interactions with acyl-coenzyme A thioesterase 8 (ACOT8), complement C1q binding protein (C1QBP), ovarian tumour domain-containing protein 4 (OTUD4), sorting nexin 9 (SNX9), and vimentin (VIM) in both Neuro-2a and 293T cells. Overexpression and knockdown experiments showed that SNX9 restricted replication of an ICP0-null but not wild-type virus in Neuro-2a cells. Ubiquitinome analysis by immunoprecipitating the trypsin-digested ubiquitin reminant followed by mass spectrometry identified numerous candidate ubiquitination substrates of ICP0 in infected Neuro-2a cells, among which OTUD4 and VIM were novel substrates confirmed to be ubiquitinated by transfected ICP0 in Neuro-2a cells despite no evidence of their degradation by ICP0. Expression of OTUD4 was induced independently of ICP0 during HSV-1 infection. Overexpressed OTUD4 enhanced type I interferon expression during infection with the ICP0-null but not wild-type virus. In summary, by combining two proteomic approaches followed by confirmatory and functional experiments, we identified and validated multiple novel targets of ICP0 and revealed potential restrictive activities of SNX9 and OTUD4 in neuronal cells.
Efficacy of Laparoscopic Surgery Combined With Leuprorelin in the Treatment of Endometriosis Associated With Infertility and Analysis of Influencing Factors for Recurrence

Objective To explore the curative effect of laparoscopic surgery combined with leuprorelin in the treatment of endometriosis with infertility and the related factors of recurrence after treatment. Methods A total of 158 patients with endometriosis and infertility were selected in our hospital from January 2019 to June 2020. Patients were randomly divided into the control group and the observation group, with 79 patients in each group. Patients in the control group was treated by laparoscopy surgery combined with dydrogesterone, while those in the observation group was treated with laparoscopic surgery combined with leuprorelin. The hormone levels, recurrence rate, pregnancy rate and adverse reaction of the two groups were compared. Combined with clinical and pathological information, the related factors of postoperative recurrence were analyzed. Results After treatment, the levels of luteinizing hormone, follicle-stimulating hormone and estradiol in the observation group were lower than those in the control group (P < 0.05). The recurrence rate at 12 months after operation in the observation group was lower than that in the control group, and the pregnancy rate was higher than that in the control group (P < 0.05). However, there was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Preoperative dysmenorrhea was an independent risk factor for postoperative recurrence in patients with endometriosis, and postoperative pregnancy was a protective factor for postoperative recurrence in patients with endometriosis (P < 0.05). Conclusion Laparoscopy combined with leuprorelin in the treatment of endometriosis with infertility can improve hormone levels, increase the pregnancy rate and reduce the recurrence rate. Preoperative dysmenorrhea is an independent risk factor for postoperative recurrence, which should be quantified and included in the recurrence risk prediction model. Postoperative pregnancy can reduce the recurrence rate after operation, and patients with fertility requirements should be encouraged to make activ preparations for postoperative pregnancy.
Analysis of Methods of Electrical Load of Permanent Magnet Synchronous Generator for Small Wind Turbines

The article compares the different ways to create and regulate electrical load of synchronous generator with permanent magnets (PMSG) in the low-power wind turbines with vertical axis (VAWT). Briefly describes the methods that allow you to adjust the electromotive force of PMSG. But focuses on such in which the simplest unregulated three phase PMSG is applied, and control of electric load is carried out by means of semiconductor converters. The methods of adjusting the electrical load were relied to each other in terms of complexity and thus of realize cost and of the value and energy efficiency. As a compromise between these indicators a combined method with a low-power DC-DC-converter, which operate at low winds, and passive control –at high winds is proposed. The research was conducted by computer simulation in Matlab/Simulink. Streszczenie: W artykule porównano różne sposoby powstawania i regulowania obciążenia elektrycznego generatorów synchronicznych z magnesami trwałymi (PMSG) w elektrowniach wiatrowych małej mocy, o pionowej osi obrotu (VAWT). Krótko opisano metody regulujące siłę elektromotoryczną PMSG. Skupiono się na metodach, w których stosuje się najprostsze trójfazowe PMSG, a regulację ich obciążenia elektrycznego prowadzi się za pomocą przetworników półprzewodnikowych. Sposoby regulowania obciążenia elektrycznego porównano pod względem efektywności energetycznej. Jako kompromis między tymi wskaźnikami zaproponowano mieszany sposób z DC-DC-przekształtnikiem małej mocy, pracującym przy niskich wiatrach i sterowaniem pasywnym – przy dużych wiatrach. Badania prowadzono z użyciem symulacji komputerowej w środowisku Matlab/Simulink.
Numerical Investigation on the Performance of an External Compression Supersonic Air Intake Using By-Pass Technique

Two-dimensional, supersonic flow field computation with by-pass holes has been conducted using Euler equation. An algorithm based on finite difference McCormack's technique is used to solve the subsonic-supersonic flow problem with and without by-passing. Trials on by-pass locations were also made. Operation without bypass shows the movement of the normal shock wave upstream which refers to an off-design operating regime. At a distance of 1.271 m measured from the cowl lip, the region of normal shock wave was localized near the throat which approximately represents the on-design perform 0ance condition (cells 8-9). When the flow is bypassed from the rear passages, the normal shock wave is sucked inside the flow passage save poor performance. Results show that by-passing provides a fast reaction to maintain a steady performance which meets the requirements of ondesign operation. The Mach number variation corresponding to each case is presented. Results show that the tendency to unity Mach number near the cowl lip sector can be achieved using by-pass expelled. The influence of by-pass on the total pressure recovery and relative pressure is also discussed.
Fully industrialised single photon avalanche diodes

Single Photon Avalanche diodes (SPADs) were first realized more than five decades ago[1][1], and have now been industrialized for mass production in the 130 nm CMOS technology node by STMicroelectronics (STM). In this paper we present the latest STM SPAD with an excellent NIR photon detection probability (>5% at 850nm), a dark count rate median of 100 cps at room temperature and a low breakdown voltage of 14.2V. The dead time of the SPAD is approximately 25 ns, leading to a maximum count rate of 40 Mcps. Thanks to the 130 nm gate length of the CMOS technology used and the associated high digital gate density, complex digital signal processing can be implemented allowing fully integrated systems to be realized. The low bias required by the SPAD makes it possible for voltage generation to be achieved on-chip (e.g. charge pumped). We introduce our first generation time-of-flight system (VL6180) based on the STM SPAD technology, which is capable of ranging up to 60 cm in 60 ms. Ranging capabilities and accuracy are measured using a set of moving targets with reflectance of 5%, 17% and 88% in a fully automated test bed. To the best of our knowledge this was the first high volume SPAD-based device. To our knowledge this is the first time details of SPAD performance over production volumes and lifetime have been presented.
Spice simulation of substrate potential shift in HVCMOS technologies

High voltage CMOS active devices inherently include a parasitic vertical PNP bipolar transistor. When activated it injects holes into the substrate causing a dangerous potential shift. In this work a spice-modeling approach based on transistor layout is presented to simulate substrate de-biasing in Smart Power ICs. The proposed model relies on a parasitic substrate network without the need of a parasitic BJT in HVCMOS compact models. The results are compared with TCAD simulations at different temperatures showing good agreement. Potential shift of the substrate is analysed for different geometrical configurations to estimate the effect of P+ grounding schemes and backside contact.
Modeling, Simulation and Harmonic Reduction of Three-Phase Multilevel Cascaded Inverters with SVPWM for Photovoltaic System

This paper presents a control for a three-phase an eleven-level cascaded H-bridge inverter for photovoltaic (PV) system. The maximum power point tracking (MPPT) is capable of extracting maximum power from the PV array connected to each DC link voltage level. The MPPT algorithm is solved by fuzzy logic controller. Space vector pulse width modulation (SVPWM) algorithm uses a simple mapping to generate gate signals for the inverter. This is done to achieve high dynamic performance with low total harmonic distortion (THD). The validity of the system is verified through MATLAB/Simulink and results are compared with three-phase three-level, five-level, seven-level and nine-level cascaded H-bridge inverter for PV system in terms of THD. Finally, simulation results are presented to verify the effectiveness and accuracy of the proposed system.
International ocean discovery program expedition 368 preliminary report: South China Sea Rifted Margin Testing hypotheses for lithosphere thinning during continental breakup: Drilling at the South China Sea rifted margin

Recommended Citation Jian, Z. , Larsen, H. , Zarikian, C. , Jian, Z. , Christian Larsen, H. , Alvarez Zarikian, C. , Bowden, S. , Cukur, D. , Dadd, K. , Ding, W. , Ferré, E. , Ferreira, F. , Gewecke, A. , Huang, E. , Jiang, S. , Jin, H. , Kurzawski, R. , Li, Y. , Li, B. , Lin, J., Liu, C. , Liu, C. , Mohn, G. , Ningthoujam, L. , Osono, N. , Peate, D. , Persaud, P., Qiu, N. , Satolli, S. , Schindlbeck, J., Straub, S. , Tian, L. , & Van Der Zwan, F. (2018). International ocean discovery program expedition 368 preliminary report: South China Sea Rifted Margin Testing hypotheses for lithosphere thinning during continental breakup: Drilling at the South China Sea rifted margin. Integrated Ocean Drilling Program: Preliminary Reports (368), 1-54. https://doi.org/10.14379/iodp.pr. 368.2018
Collaborative working environment and knowledge databank for agroforestry training and education

The aim of the AgroFE project (http://www.agrofe.eu) is to develop vocational training in the field of agroforestry in six countries. Several levels of training are targeted by the project, levels N3-N4 relate to farmers and future farmers, levels N5-N6 affect (future) advisors, trainers, teachers, and technicians who are working in the domain. In the context of ICT related to the AgroFE project there are four components: the collaborative tools, the knowledge databank, the tools for training and a portal that integrates the tools. The Agrof-MM Erasmus+ project reinforces the AgroFE project that ended in December 2015. The objective of the Agrof-MM project is to train European agricultural stakeholders in agroforestry practices. The project will give them the opportunity to familiarise themselves with agroforestry, and to improve their knowledge of it, in order to work towards the development of agroforestry in the Mediterranean and mountain regions of Europe.
Symmetrical and Asymmetrical of TAM: Consumer Emotional Value and Service Innovation on Consumer Purchase Decisions

This article presents the results of the mapping carried out taken from various sources, with a total of 34 papers used as mapping materials. Based on the existing theory, TAM consists of several factors, namely risk factors, usability, and added value. The community can accept the stronger these three factors, the more robust technology. These factors can lead to an acceptance of feelings of emotional value or commonly refer to as perceived emotional value. A person can receive emotional value after using the technology, and an emotional value can occur because of innovation. These two things can make a decision someone will use the technology. This study aims to determine the symmetrical and asymmetrical relationship between TAM and Emotional Value, Service Innovators, and also Consumer Purchase Decisions.
Student-instructor communication during a crisis: college students’ disclosures about academic struggles and perceived instructor supportiveness and flexibility during the COVID-19 pandemic

ABSTRACT This study investigates student disclosures of academic struggles to their instructors during the COVID-19 pandemic. An online survey was administered to U.S. college students (N = 458) who were enrolled in classes during the COVID-19 pandemic. Students’ breadth, depth, and frequency of disclosures of academic struggles were examined in conjunction with students’ perceptions of instructor characteristics, such as instructor supportiveness and flexibility, contextual criteria for disclosure, and risk of disclosure. The study findings indicate that instructor supportiveness and instructor flexibility were significant predictors of the breadth of student disclosures. Students’ depth and frequency of disclosures also were significantly predicted by instructor supportiveness. Further, students’ perceptions of the risk of disclosure were significantly related to both instructor supportiveness and instructor flexibility. Finally, students’ disclosure of academic struggles to their instructors during the COVID-19 pandemic were significantly predicted by the contextual criteria important reason and conversational appropriateness. Analysis of open-ended survey responses indicated that students are willing to disclose their academic struggles to instructors who are open-minded and willing to self-disclose their own struggles. The implications of the present study results on instructor-student communication in times of crisis and post-COVID-19 are discussed.
Design of an Inverter with Facts Capability for Distributed Energy Sources

In this work, a wind energy inverter with flexible AC transmission system (FACTS) capability is presented. The proposed inverter is placed between the wind turbine and the grid, same as a regular inverter, and is able to regulate reactive power transferred to the grid. This inverter is equipped with distribution static synchronous compensators option in order to control the reactive power of the local feeder lines. Using the proposed inverter for small-to medium-size wind applications will eliminate the use of capacitor banks as well as FACTS devices to control the reactive power of the distribution lines. The goal of this work is to introduce new ways to increase the penetration of renewable energy systems into the distribution systems. This will encourage the utilities and customers to act not only as a consumer, but also as a supplier of energy. Moreover, designing such inverters with FACTS capabilities will significantly reduce the total cost of the renewable energy application. The inverter is designed in such a manner to meet all the requirements of a power system network such as compatibility with IEEE standards, total harmonic distortion (THD), efficiency, and total cost of the system. The proposed control strategy regulates the reactive power using modulation index. SHE modulation technique is used. This will help to reduce the THD value and will replace the use of an extra L-C filter to the system. The function of the proposed inverter is to transfer active power to the grid as well as keeping the reactive power of the local power lines within the satisfactory limit regardless of the incoming active power from the wind turbine. The simulations have been done in MATLAB/Simulink.
Przełomowe innowacje jako sposób rozwoju uniwersyteckiej przedsiębiorczości na przykładzie masowych otwartych kursów online MOOCs

Zmiany zachodzące w otoczeniu spoleczno-gospodarczym wplywają zarowno na sfere dzialalności komercyjnej, jak i niekomercyjnej roznych organizacji. Dotyczy to rowniez obszaru szkolnictwa wyzszego, w ramach ktorego ciągle poszukuje sie rozwiązan spelniających oczekiwania interesariuszy – począwszy od pracownikow, przez studentow i doktorantow, koncząc na rynku pracy i spoleczenstwie ogolem. Zmiany te rodzą istotne dylematy i wymagają podjecia zdecydowanych dzialan. Celem artykulu jest proba zarysowania jednego z mozliwych kierunkow rozwoju wspolczesnych szkol wyzszych w ramach dośc powszechnej wśrod wielu autorow koncepcji przedsiebiorczego uniwersytetu z wykorzystaniem teorii przelomowych innowacji Christensena.
Assessment the Effect of Human Umbilical Cord Wharton's Jelly Stem Cells on the Expression of Homing Genes; CXCR4 and VLA-4 in Cell Line of Breast Cancer

Background: Breast cancer is the most common cancer in women. The prevalence of breast cancer in Western women is one in eight. Although the prevalence of breast cancer in Iran is lower than in Western countries (one in every 10-12 women), the incidence of breast cancer in it is 5-10 years earlier than in Western countries. Breast cancer is the second leading cause of cancer death among women after lung cancer. Therefore, finding new therapeutic methods could potentially help to reduce breast cancer mortality and increase the survival rate. Wharton jelly stem cells with mesenchymal morphology play an important role in inhibiting the progression of ovarian, osteosarcoma, and breast cancer by inducing apoptosis and reducing metastasis. Several environmental and genetic factors are involved in the occurrence of breast cancer. CXCR4 and VLA-4 genes are important genetic factors in breast cancer that play a role in cell survival, migration, proliferation, and metastasis of several types of cancer, especially breast cancer. Therefore, inhibition of these two genes by Wharton's Jelly Stem Cells could be a novel and effective therapeutic target in breast cancer. The aim of this study was to investigate the effect of Wharton jelly stem cells secretion on the expression of CXCR4 and VLA-4 genes in cancer cells. Materials and Methods: These cells were exposed to Wharton's Jelly Stem Cells after culturing breast cancer cells. RNA was extracted from treated cells. The expression of CXCR4 and VLA-4 genes was evaluated by real-time PCR. Results: The results of the MTT and Scratching tests showed a significant difference compared to the control group. Also, the results of Real-time PCR showed a significant decrease in the expression of CXCR4 and VLA-4 genes compared to the control group. Conclusion: The results of this study showed that different concentrations of Wharton Jelly Stem Cells reduce cancer cell growth and expression of CXCR4 and VLA-4 homing genes in MDA-MB-231 breast cancer cells. Therefore, Wharton Jelly Stem Cells can be considered as an effective treatment for breast cancer.