Miracle-dz/UniFAR-FTUs huggingface dataset:
Study and application of dynamic matrix control in refinery processes

Advanced process control (APC) technologies have been widely used to improve plant profitability and reliability in the last several decades. Dynamic matrix control (DMC) is one of these technologies, and plays an important role in refinery and petrochemical plant APC practice. There are many factors that may impact the success of an APC project, including technological and non-technological issues. The engineering aspects of APC project are discussed and explained by the details of execution of a crude unit APC application. The purpose of this paper is to highlight how to integrate DMC technology and fundamental process control knowledge for getting the APC project done.
Modelling steel demand in the UK

Overinvestment in the steel industry is very costly and often results from an inability to assess the processes determining steel demand. To help understand the factors affecting steel consumption, a simple model for the UK is developed and estimated. The model relates steel consumption to changes in the intensity of use and the level of economic activity. The results indicate that steel intensity of use (SIU) in the UK has declined because of a reduction in the relative size of the manufacturing and construction sectors, a growth in high technology industries, and resource saving technological change. Steel prices are shown to have had little effect on SIU. The model is capable of explaining the general downward direction in SIU and many of the cyclical movements - most notably the temporary upturn in the late 1980s. This represents a substantial improvement on the intensity of use hypothesis.
COLLABORATIVE COMMUNITIES: COHOUSING, CENTRAL LIVING, AND OTHER NEW FORMS OF HOUSING WITH SHARED FACILITIES

nificance are efforts to operate national parks in the Northern Territory on lease-back arrangements with the Aborigines who own the land and participate in management decisions (Alanen 1992). Many Americans and other people may form most of their impressions about Australia from Crocodile Dundee movies and Quantas Airline advertisements, even while expressing curiosity about life "down under. " As both landscape architecture and town planning mature in Australia, we can expect to see the emergence of an increasing number of well-conceived projects and studies that have meaning and implications for a much broader international audience. Robert Freestone’s Model Communities will assist those who wish to place these emerging activities into a broader historical context.
An Empirical Investigation into the Reproduction of Bug Reports for Android Apps

One of the key tasks related to ensuring mobile app quality is the reporting, management, and resolution of bug reports. As such, researchers have committed considerable resources toward automating various tasks of the bug management process for mobile apps, such as reproduction and triaging. However, the success of these automated approaches is largely dictated by the characteristics and properties of the bug reports they operate upon. As such, understanding mobile app bug reports is imperative to drive the continued advancement of report management techniques. While prior studies have examined high-level statistics of large sets of reports, we currently lack an in-depth investigation of how the information typically reported in mobile app issue trackers relates to the specific details generally required to reproduce the underlying failures. In this paper, we perform an in-depth analysis of 180 re-producible bug reports systematically mined from Android apps on GitHub and investigate how the information contained in the reports relates to the task of reproducing the described bugs. In our analysis, we focus on three pieces of information: the environment needed to reproduce the bug report, the steps to reproduce (S2Rs), and the observed behavior. Focusing on this information, we characterize failure types, identify the modality used to report the information, and characterize the quality of the information within the reports. We find that bugs are reported in a multi-modal fashion, the environment is not always provided, and S2Rs often contain missing or non-specific enough information. These findings carry with them important implications on automated bug reproduction techniques as well as automated bug report management approaches more generally.
Regulating the Immune Responses in Mice Distinct Roles of Adenylyl Cyclase VII in

The second messenger cAMP plays a critical role in regulating immune responses. Although well known for its immunosuppressive effect, cAMP is also required for the development of optimal immune responses. Thus, the regulation of this second messenger needs to be ﬁnely tuned and well balanced in a context dependent manner. To further understand the role of cAMP synthesis in the functions of the immune system, we focus on a speciﬁc adenylyl cyclase (AC) isoform, AC VII (AC7), which is highly expressed in the immune system. We show that mice deﬁcient of AC7 are hypersensitive to LPS-induced endotoxic shock. Macrophages from AC7-deﬁcient mice produce more of the proinﬂammatory cytokine, TNF- a , in response to LPS. The inability to generate intracellular cAMP response to serum factors, such as lysophosphatidic acid, is a potential cause for this phenotype. Thus, AC7 functions to control the extent of immune responses toward bacterial infection. However, it is also required for the optimal functions of B and T cells during adaptive immune responses. AC7 is the major isoform that regulates cAMP synthesis in both B and T cells. AC7-deﬁcient mice display compromised Ab responses toward both T cell-independent and T cell-dependent Ags. The generation of memory T cells is also reduced. These results are the ﬁrst to ascribe speciﬁc functions to an AC isoform in the immune system and emphasize the importance of cAMP synthesis by this isoform in shaping the immune responses. The Journal of Immunology , 2010, 185: 335–344. wild-type s and unique of AC7 in the immune system potential function of this AC isoform in immune the functions of AC7 in both and Ab responses in vivo. AC7-deﬁcient mice severe embryonic lethality ( we bone chimeric mice AC7 is only deleted in the system. AC7-deﬁcient bone marrow cells able regenerate the immune system and the ratio of B cells and T cells appeared to be normal. the chimeric mice showed reduced total numbers of lymphocytes, AC7 might play a role in hematopoiesis. These chimeric mice displayed hypersensitivity to LPS-induced endotoxic shock. In vitro analyses using BMDMs suggest that AC7 senses factor(s) present in the serum to control the extent of TLR signaling via intracellular cAMP changes. In contrast, chimeric mice carrying AC7-deﬁcient immune system displayed compromised Ab responses to challenges with either T cell-independent (TI) or T cell-dependent (TD) Ags. We show that AC7 is the major AC isoform that regulates cAMP synthesis in both B cells and T cells. Our results demonstrate that the speciﬁc AC isoform, AC7, has multifaceted roles in regulating both innate and adaptive immune responses. It prevents hyperactive immune responses to bacterial infection while enabling optimal Ab responses. This is the ﬁrst study that ascribes the functions of a speciﬁc AC isoform in the immune system and it highlights the importance of the dynamic regulation
Effects of an Intervention with educational phone calls to improve adherence and metabolic control in people with type 2 diabetes mellitus: A randomized clinical trial

of intervention with telephone calls in outpatients with poorly controlled atención e invitó al estudio a todos los adultos con glycosylated hemoglobin at three months. 94 participants were recruited (47 in each group). Mean age was 59.8 Results: years (SD: 10.2), 69.2 % were women. At three months, only 14/47 participants in the control group and 13/47 participants in the intervention group had HbA1c measurement. Among these, the percentage of those who achieved a ≥ 1% decrease in HbA1c was 35,7% (5/14) in the control group and 53,8% (7/13) in the intervention group (RR: 0,72, 95% CI: 0,35-1,47). No diﬀerences were found in adherence to treatment between groups. No statistically signiﬁcant diﬀerences Conclusions: were found for the outcomes of interest. This is possibly due to the low percentage of participants who were able to complete follow-up. Innovative solutions are needed to improve the control of people with DM2.
Leishmaniasisand Th2-Like Responses in Visceral IL-4 Generation: Evidence for Mixed Th1-Inducible Nitric Oxide Synthase Activity and That Correlates with Leishmania donovani of Antimonial-Sensitive and -Resistant Strains against Both Pentavalent Vaccination Induces Complete Protection Kinetoplastid 

The emergence of an increasing number of Leishmania donovani strains resistant to pentavalent antimonials (SbV), the ﬁrst line of treatment for visceral leishmaniasis worldwide, accounts for decreasing efﬁcacy of chemotherapeutic interventions. A kinetoplastid membrane protein-11 (KMP-11)-encoding construct protected extremely susceptible golden hamsters from both pentavalent antimony responsive (AG83) and antimony resistant (GE1F8R) virulent L. donovani challenge. All the KMP-11 DNA vaccinated hamsters continued to survive beyond 8 mo postinfection, with the majority showing sterile protection. Vaccinated hamsters showed reversal of T cell anergy with functional IL-2 generation along with vigorous speciﬁc anti-KMP-11 CTL-like response. Cytokines known to inﬂuence Th1- and Th2-like immune responses hinted toward a complex immune modulation in the presence of a mixed Th1/Th2 response in conferring protection against visceral leishmaniasis. KMP-11 DNA vaccinated hamsters were protected by a surge in IFN- (cid:1) , TNF- (cid:2) , and IL-12 levels along with extreme down-regulation of IL-10. Surprisingly the prototype candidature of IL-4, known as a disease exacerbating cytokine, was found to have a positive correlation to protection. Contrary to some previous reports, inducible NO synthase was actively synthesized by macrophages of the protected hamsters with concomitant high levels of NO production. This is the ﬁrst report of a vaccine conferring protection to both antimony of response in VL CTL-like
InjuryOntogeny and Functions in Acute Liver and Resident Kupffer Cells Display Different Infiltrating Monocyte-Derived Macrophages

The liver has a remarkable capacity to regenerate after injury; yet, the role of macrophages (MF) in this process remains controversial mainly due to difﬁculties in distinguishing between different MF subsets. In this study, we used a murine model of acute liver injury induced by overdose of N- acetyl-p-aminophenol (APAP) and deﬁned three distinct MF subsets that populate the liver following injury. Accordingly, resident Kupffer cells (KC) were signiﬁcantly reduced upon APAP challenge and started recovering by self-renewal at resolution phase without contribution of circulating Ly6C hi monocytes. The latter were recruited in a CCR2-and M-CSF–mediated pathway at the necroinﬂammatory phase and differentiated into ephemeral Ly6C lo MF subset at resolution phase. Moreover, their inducible ablation resulted in impaired recovery. Microarray-based molecular proﬁling uncovered high similarity between steady-state KC and those recovered at the resolution phase. In contrast, KC and monocyte-derived MF displayed distinct prorestorative genetic signature at the resolution phase. Finally, we show that inﬁltrating monocytes acquire a prorestorative polarization manifested by unique expression of proangiogenesis mediators and genes involved with inhibition of neutrophil activity and recruitment and promotion of their clearance. Collectively, our results present a novel phenotypic, ontogenic, and molecular deﬁnition of liver-MF compartment following acute injury. The Journal of Immunology , 2014, 193: 000–000.
Epidemic Dynamics of a Fractional-Order SIR Weighted Network Model and Its Targeted Immunity Control

With outbreaks of epidemics, an enormous loss of life and property has been caused. Based on the influence of disease transmission and information propagation on the transmission characteristics of infectious diseases, in this paper, a fractional-order SIR epidemic model is put forward on a two-layer weighted network. The local stability of the disease-free equilibrium is investigated. Moreover, a conclusion is obtained that there is no endemic equilibrium. Since the elderly and the children have fewer social tiers, a targeted immunity control that is based on age structure is proposed. Finally, an example is presented to demonstrate the effectiveness of the theoretical results. These studies contribute to a more comprehensive understanding of the epidemic transmission mechanism and play a positive guiding role in the prevention and control of some epidemics.
Early School Leaving and Transition to Adulthood: A Case Study of a Spanish Mediterranean Region

In this study, the processes of transition to adulthood of early school leavers were analysed with special emphasis on the heterogeneity of situations that arise in this group. A quantitative methodology has been used including data collection via questionnaires with a total sample of 580 participants (306 women and 274 men) in the age range 26–28. Firstly, we have analysed the influence of educational level and gender in emancipation, employment, and parenting processes. Secondly, seven models of transition were identified based on the combination of main markers of transition to adulthood. Results showed the strong impact of educational level and gender on youth transitions, and the great vulnerability of youth with a low educational level specifically in employment and being these difficulties greater for women.
The Effects of the Project Management Office on Companies Performance - A Case Study on a Project-Oriented Company

The purpose of this paper is to investigate the specific role of the Project Management Office (PMO) in a multiproject environment that how we can implement it with more efficiency. Research indicates that project management becomes increasingly difficult when there are many overlapping projects in a project-oriented company, resulting in a need for enhanced governance controls to increase success rates. It caused with implementation of a system that helps project management, the system named Project Management Office (PMO) that is special for companies that are project-oriented and has many overlapping projects. The Project Management Office with a special model that will explain let us to have management of multiple projects efficiently in a projectoriented company. Using a case study to test the method of research found that PMOs perform the PMO effects to different degrees and it is through performing these that the PMO delivers value to the company. After the system implementation, a qualitative evaluation was carried out by a document analysis and questionnaire application.
Modular Service Design of Information Technology-Enabled Services

The literature has proposed ways to modularize information-technology-enabled services (ITeS) with limited success. We argue that applying design principles (DPs) can address this gap and revitalize the service modularization literature. With a qualitative research study, we develop exemplar DPs and a set of prioritized DPs for ITeS. We contribute to the literature by demonstrating how complex service systems, specifically ITeS, can be modularly designed. Our DPs show how different ITeS design elements or service attribute combinations impact the outcome-driven design of service experience. Based on the findings, we present a modular service design framework and a service design method that adopts DPs to create effective modular ITeS designs. We also offer ways to conceptualize and apply service modularization to improve the adoption of the modular service design by service designers and managers. Graphical Abstract
Increasing the energy density of high‐moisture wastes of beverage industry by hydrothermal pretreatment: Comparison of thermochemical conversion behaviors

Hydrothermal pretreatment is an effective method to increase the energy density of biowastes with high moisture content. Since the hydrothermal pretreatment slightly modifies the lignocellulosic structure, the thermochemical conversion behavior of the biomass also changes. In the present study, grape pomace (GP) and fermentation sludge (FS) were hydrothermally pretreated at 220°C and 90 minutes. The fuel properties, pyrolysis, and combustion behaviors of the corresponding hydrochars were compared. After pretreatment, the fixed carbon content (wt%) of GP increased by 7.2% and that of FS by 16.8%, while the ash content (wt%) of GP decreased by 77.6% and that of FS by 38.8%. Due to a decrease in both H/C and O/C, the heating value of GP and FS increased by 11% and 36%, respectively. Upon pretreatment, ignition temperatures were shifted from 245.8°C to 295.8°C for GP and 273°C to 279°C for FS. Burnout temperatures were also shifted to 725°C for GP, and 700°C for FS. The increase in activation energies after pretreatment (from 20.4 to 32 kJ/mol for GP, from 24.3 to 36.3 kJ/mol for FS) showed that the pyrolysis process was slowed down. The main volatile compounds (compounds containing C═O and CO2) detected from Fourier transform infrared (FTIR) in the pyrolysis of GP were formed at higher temperatures after hydrothermal pretreatment. In the pyrolysis of FS, the main volatile compounds (CO2 and CH4) were seen at lower temperatures after pretreatment. According to the fast pyrolysis results in Py‐GC/MS, hydrothermal pretreatment caused an increase in esters and a decrease in fatty acids and ketones. Phenols were the dominant group in the pyrolysis products of GP after pretreatment, while other hydrocarbons, esters, and aromatic hydrocarbons were seen in FS besides phenols.
miR 31-3p Has the Highest Expression in Cesarean Scar Endometriosis

Micro-RNAs expression can vary between different forms of endometriosis, but data on miRNA expression in cesarean scar endometriosis is lacking. The present study is comprised of 30 patients with endometriosis in the cesarean scar (scar endometriosis, SE), 14 patients with deep infiltrating endometriosis (DIE), 47 patients with endometrioma (ovarian endometrial cyst, OE), and 33 patients with healthy ovarian tissue as the control group (CG). In the initial experiment to identify possible dysregulated miRNAs, the levels of 754 miRNAs in formalin-fixed paraffin-embedded tissue (FFPE) samples from OE, high-grade ovarian cancer, endometrioid ovarian cancer, and CG were measured. We identified seven potentially dysregulated miRNAs: miR-1-3p, miR-31-3p, miR-125b-1-3p, miR-200b-3p, miR-548d, miR-502, and miR-503. We then examined the expression profiles of each of these miRNAs individually in the SE, DIE, OE, and CG FFPE samples using RT-qPCR. miR-31-3p had significantly higher levels of expression and miR-125b-1-3p had significantly lower levels of expression in SE compared to the controls. Overall, the higher expression levels of miR-31-3p and the lower expression levels of miR-125b-1-3p are consistent with the benign nature of SE. Importantly, the results of the present study demonstrate the possibility of using miRNA to monitor the risk of malignant transformation of endometriosis tissue.
Etlingera elatior Flower Aqueous Extract Protects against Oxidative Stress-Induced Nephropathy in a Rat Model of Type 2 Diabetes

Diabetes mellitus (DM) is a known systemic disease with increasing global prevalence and multi-organ complications including diabetic nephropathy (DN). The trend of using medicinal plants in the management of DM is increasing exponentially. Etlingera elatior is a medicinal plant that contains chemicals and antioxidants that delay the oxidation process. However, available data focusing on its use on DN are inconsistent and scarce. This study aims to investigate the antidiabetic and nephroprotective effects of E. elatior flower aqueous extract (EEAE) in a type 2 DM rat (T2DR) model. The T2DR model was developed using a combination of a high-fat diet (HFD) and a low dose of streptozotocin (STZ) at 35 mg/kg. Thirty-two Sprague Dawley male rats were randomly divided into four groups (n = 8): (1) control (normal rat), (2) T2DR (untreated-type 2 diabetic rat), (3) Met (250 mg/kg metformin-treated T2DR), and (4) EEAE (1000 mg/kg EEAE-treated T2DR). All treatments were administered orally for 6 weeks. EEAE significantly reduced fasting blood glucose (FBG), microalbuminuria, serum creatinine, and serum blood urea nitrogen. EEAE also reduced malondialdehyde (MDA) and enhanced the levels of antioxidant markers—superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and total antioxidant capacity (T-AOC). The inflammatory marker (interleukin (IL)-6) and fibrosis markers (transforming growth factor-beta (TGF-β), and connective tissue growth factor (CTGF)) were significantly decreased in the EEAE-treated group. The T2DR group developed DN, which was characterized by segmental sclerosis of the glomeruli associated with focal tubular atrophy and interstitial fibrosis. Interestingly, the histology of kidney tissue in the EEAE group was preserved. This effect was similar to that of the control drug metformin. In summary, the antidiabetic and nephroprotective effects might be related to the antioxidant properties and anti-inflammatory effects of the EEAE. The antidiabetic activity could be due to the presence of the active compound cyanidin-3-O-glycosides, which is an anthocyanin antioxidant, that is present in the EEAE. E. elatior has the potential to be developed as a natural source of antioxidants that can be used for the prevention or even the treatment of DM. These findings could lead to future research into the therapeutic use of E. elatior in alleviating the progression of DM and thus preventing nephropathy.
Improvement and self-assessment in the quality management of the enterprises (Doskonalenie i samoocena w zarzadzaniu jakoscia w przedsiebiorstwie)

This paper presents the theoretical basis for self-assessment of quality management in the wider perspective of improvement. The choice of approach to quality management determines the range of the self-assessment possibilities of the level of maturity with regards to the company quality. The basis for self-reference can be by implementing the principles of excellence according to the EFQM model. The results of the analysis show that, in terms of requirements and normative principles of quality management system (QMS) is not consistent with the principles of the EFQM excellence. Therefore, the level of perfection of normative QMS evaluated according to criteria of the EFQM model may not be the highest (mature). Moreover, the EFQM self-assessment model shows the relationship of comprehensive quality management (TQM), with which it is connected by means of both the principles and elements. Assuming that TQM is not an integral part of the normative QMS, we can say that the TQM self-assessment is more about the improvement than the self-assessment of the normative self-QMS.
SIMULATION AND ANALYSIS STUDIES FOR A MODIFIED ALGORITHM TO IMPROVE TCP IN LONG DELAY BANDWIDTH PRODUCT NETWORKS

It is well known that TCP has formed the backbone of the Internet stability and has been well tuned over years. Today the situation has changed, that is because the internetworking environment become more complex than ever, resulting in changes in TCP congestion control are produced and still in progress. In this paper we use an analytic fluid approach in order to analyze the different features of slow start, traditional swift start, and modified swift start algorithms. We then use simulations to confirm our analytic results which are promising enough.