Miracle-dz/UniFAR-FTUs huggingface dataset:
SmDXS5, acting as a molecular valve, plays a key regulatory role in the primary and secondary metabolism of tanshinones in Salvia miltiorrhiza

Red sage, the dry root and rhizome of the herbaceous plant Salvia miltiorrhiza Bunge, is widely used for treating various diseases. The low content of tanshinones (terpenoids) has always restricted development of the S. miltiorrhiza industry. Here, we found that SmDXS5, a rate-limiting enzyme-coding gene located at the intersection of primary and secondary metabolism, can effectively change the transcription level and secondary metabolome profile of hairy roots of S. miltiorrhiza, and significantly increase the content of tanshinones. Agrobacterium rhizogenes was used to infuse S. miltiorrhiza explants, and hairy roots of S. miltiorrhiza expressing the SmDXS5 gene were obtained successfully. We identified 39 differentially accumulated metabolites (DAMs) by metabolomics based on ultra-high performance liquid chromatography quadrupole exactive mass spectrometry and multivariate statistics. These DAMs might be key metabolites of SmDXS5 gene regulation. RNA sequencing was used to compare gene expression between the hairy roots of the SmDXS5 overexpressing group and the blank control (BC) group. Compared with the BC group, 18,646 differentially expressed genes were obtained: 8994 were upregulated and 9,652 downregulated. The combined transcriptome and metabolome analyses revealed that the mevalonate and methylerythritol phosphate pathways and synthase gene expression levels in the SmDXS5 overexpressing group were upregulated significantly, and the accumulation of tanshinone components was increased significantly, which promoted the process of glycolysis and promoted the transformation of carbohydrates to secondary metabolism. Moreover, the expression of SmPAL, the first rate-limiting enzyme gene of the phenylpropane pathway, decreased, reducing the accumulation of phenolic acid, another secondary metabolite. Therefore, SmDXS5 can be defined as a ‘valve’ gene, mainly responsible for regulating the distribution of primary and secondary metabolic flow of tanshinones in S. miltiorrhiza, and for other secondary metabolic pathways. The discovery of SmDXS5 and its molecular valve function in regulating primary and secondary metabolism will provide a basis for the industrial production of tanshinone components, and cultivation of high quality S. miltiorrhiza.
Short-term outcomes of near-infrared imaging using indocyanine green in laparoscopic lateral pelvic lymph node dissection for middle-lower rectal cancer: A propensity score-matched cohort analysis

Laparoscopic lateral pelvic lymph node dissection (LPND) is limited by complex neurovascular bundles in the narrow pelvic sidewall and various post-operative complications. Indocyanine green (ICG) has been applied to increase the number of harvested lymph nodes and reduce the injury of irrelevant vessels in patients with rectal cancer. However, few studies on the recurrence rate of ICG fluorescence imaging-guided laparoscopic LPND were reported. This retrospective study enrolled 50 middle- low rectal cancer patients who were treated by LPND. After propensity score matching, 20 patients were matched in each of the indocyanine green (ICG) guided imaging group (ICG group) and non-ICG guided imaging group (non-ICG group). The average follow-up time was 13.5 months (12–15 months). Our results showed that the total number of harvested lymph nodes in the ICG group was significantly higher than that in the non-ICG group (P < 0.05), and intraoperative blood loss and post-operative hospital stay times in the ICG group were less than those in the non-ICG group (P < 0.05). After 12 months of follow-up, no residual lymph node and local tumor recurrence were found for patients in the ICG group. Four patients in the non-ICG group detected residual lymph nodes at the 3-month visit. Our findings highlighted the importance of ICG fluorescence-guided imaging in LPND because it has unique advantages in improving the number of lymph node dissections, surgical accuracy, and decreasing the residual lymph nodes and local tumor recurrence. In addition, ICG fluorescence guidance technology can effectively shorten the operation time, and it is simple to operate, which is worth popularizing.
Testing Einstein's time dilation under acceleration using Mössbauer spectroscopy

The Einstein time dilation formula was tested in several experiments. Many trials have been conducted to measure the transverse second-order Doppler shift by Mössbauer spectroscopy using a rotating absorber, to test the validity of this formula. Such experiments are also able to test if the time dilation depends only on the velocity of the absorber, as assumed by Einstein's clock hypothesis, or whether the present centripetal acceleration contributes to the time dilation. We show here that because the experiment requires γ-ray emission and detection slits of finite size, the absorption line is broadened, by geometric longitudinal first-order Doppler shifts immensely. Moreover, the absorption line is non-Lorentzian. We obtain an explicit expression for the absorption line for any angular velocity of the absorber. The analysis of the experimental results in all previous experiments which did not observe the full absorption line itself were wrong and the conclusions doubtful. The only proper experiment was done by Kündig (1963 Phys. Rev. 129 2371), who observed the broadening, but associated it with random vibrations of the absorber. We establish necessary conditions for the successful measurement of a transverse second-order Doppler shift by Mössbauer spectroscopy. We indicate how the results of such an experiment can be used to verify the existence of a Doppler shift due to acceleration and to test the validity of Einstein's clock hypothesis.
Primary pulmonary T-cell lymphoma after operation for small intestinal stromal tumor: A case report

Background The risk of gastrointestinal stromal tumor (GIST) in combination with other primary malignancies is high, which occurs before and after the diagnosis of GIST. Primary pulmonary T-cell lymphoma is a rare type of non-Hodgkin lymphoma. Case presentation We report a 53-year-old male patient who was admitted to our hospital with fever, cough, and expectoration for 2 weeks. Chest computed tomography (CT) showed a cavitary mass in the left lower lobe with multiple nodules in the upper lobes of both lungs. The patient had a history of surgery for small intestinal stromal tumors and was treated with oral imatinib after surgery. Lung biopsy was diagnosed as lymphomatoid granulomatosis, tending to grade 3. The pathological diagnosis was corrected by surgery and genetic testing for lung non-Hodgkin CD8-positive cytotoxic T-cell lymphoma with Epstein–Barr virus (EBV) infection in some cells. After multiple chemotherapies, the CT scan showed a better improvement than before. The patient is still under follow-up, and no tumor recurrence has been found. Conclusion Patients with a history of GIST should be monitored for other malignancies. The clinical symptoms and imaging examinations of primary pulmonary T-cell lymphoma are not characteristic, and the definite diagnosis still depends on pathological examination. The patient was treated with the CHOP chemotherapy regimen after the operation, the curative effect was good.
Effective theories of flavor and the nonuniversal MSSM

Flavor symmetries a la Froggatt-Nielsen provide a compelling way to explain the hierarchies of fermionic masses and mixing angles in the Yukawa sector. In supersymmetric (SUSY) extensions of the Standard Model where the mediation of SUSY breaking occurs at scales larger than the breaking of flavor, this symmetry must be respected not only by the Yukawas of the superpotential but also by the soft-breaking masses and trilinear terms. In this work we show that contrary to naive expectations, even starting with completely flavor blind soft breaking in the full theory at high scales, the low-energy sfermion mass matrices and trilinear terms of the effective theory, obtained upon integrating out the heavy mediator fields, are strongly nonuniversal. We explore the phenomenology of these SUSY flavor models after the latest LHC searches for new physics.
STATISTICAL PROPERTIES OF SUPER-HOT SOLAR FLARES

We use Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) high-resolution imaging and spectroscopy observations from ∼6 to 100 keV to determine the statistical relationships between measured parameters (temperature, emission measure, etc.) of hot, thermal plasma in 37 intense (GOES M- and X-class) solar flares. The RHESSI data, most sensitive to the hottest flare plasmas, reveal a strong correlation between the maximum achieved temperature and the flare GOES class, such that “super-hot” temperatures >30 MK are achieved almost exclusively by X-class events; the observed correlation differs significantly from that of GOES-derived temperatures, and from previous studies. A nearly ubiquitous association with high emission measures, electron densities, and instantaneous thermal energies suggests that super-hot plasmas are physically distinct from cooler, ∼10–20 MK GOES plasmas, and that they require substantially greater energy input during the flare. High thermal energy densities suggest that super-hot flares require strong coronal magnetic fields, exceeding ∼100 G, and that both the plasma β and volume filling factor f cannot be much less than unity in the super-hot region.
On thermality of CFT eigenstates

The Eigenstate Thermalization Hypothesis (ETH) provides a way to understand how an isolated quantum mechanical system can be approximated by a thermal density matrix. We find a class of operators in (1+1)-d conformal field theories, consisting of quasi-primaries of the identity module, which satisfy the hypothesis only at the leading order in large central charge. In the context of subsystem ETH, this plays a role in the deviation of the reduced density matrices, corresponding to a finite energy density eigenstate from its hypothesized thermal approximation. The universal deviation in terms of the square of the trace-square distance goes as the 8th power of the subsystem fraction and is suppressed by powers of inverse central charge (c). Furthermore, the non-universal deviations from subsystem ETH are found to be proportional to the heavy-light-heavy structure constants which are typically exponentially suppressed in √ h/c, where h is the conformal scaling dimension of the finite energy density state. We also examine the effects of the leading finite size corrections. ar X iv :1 70 5. 03 00 1v 2 [ he pth ] 2 6 A ug 2 01 7
Canny Algorithm, Cosmic Strings and the Cosmic Microwave Background

We describe a new code to search for signatures of cosmic strings in cosmic microwave anisotropy maps. The code implements the Canny algorithm, an edge detection algorithm designed to search for the lines of large gradients in maps. Such a gradient signature which is coherent in position-space is produced by cosmic strings via the Kaiser–Stebbins effect. We test the power of our new code to set limits on the tension of the cosmic strings by analyzing simulated data, with and without cosmic strings. We compare maps with a pure Gaussian scale-invariant power spectrum with maps which have a contribution of a distribution of cosmic strings obeying a scaling solution. The maps have angular scale and angular resolution comparable to what current and future ground-based small-scale cosmic microwave anisotropy experiments will achieve. We present tests of the codes, indicate the limits on the string tension which could be set with the current code, and describe various ways to refine the analysis. Our results indicate that when applied to the data of ongoing cosmic microwave experiments such as the South Pole Telescope project, the sensitivity of our method to the presence of cosmic strings will be more than an order of magnitude better than the limits from existing analyses.
OBSERVATIONAL TEST OF STOCHASTIC HEATING IN LOW-β FAST-SOLAR-WIND STREAMS

Spacecraft measurements show that protons undergo substantial perpendicular heating during their transit from the Sun to the outer heliosphere. In this paper, we use Helios 2 measurements to investigate whether stochastic heating by low-frequency turbulence is capable of explaining this perpendicular heating. We analyze Helios 2 magnetic field measurements in low-β fast-solar-wind streams between heliocentric distances r = 0.29 AU and r = 0.64 AU to determine the rms amplitude of the fluctuating magnetic field, δBp, near the proton gyroradius scale ρp. We then evaluate the stochastic heating rate Q⊥stoch using the measured value of δBp and a previously published analytical formula for Q⊥stoch. Using Helios measurements we estimate the “empirical” perpendicular heating rate that is needed to explain the T⊥p profile. We find that Q⊥stoch ∼ Q⊥emp, but only if a key dimensionless constant appearing in the formula for Q⊥stoch lies within a certain range of values. This range is approximately the same throughout the radial interval that we analyze and is consistent with the results of numerical simulations of the stochastic heating of test particles in reduced magnetohydrodynamic turbulence. These results support the hypothesis that stochastic heating accounts for much of the perpendicular proton heating occurring in low-β fast-wind streams.
Planetary nebulae as kinematic tracers of galaxy stellar halos

Abstract The kinematic and dynamical properties of galaxy stellar halos are difficult to measure because of the faint surface brightness that characterizes these regions. Spiral galaxies can be probed using the radio Hi emission; on the contrary, early-type galaxies contain less gas, therefore alternative kinematic tracers need to be used. Planetary nebulae (PNe) can be easily detected far out in the halo thanks to their bright emission lines. It is therefore possible to map the halo kinematics also in early-type galaxies, typically out to 5 effective radii or beyond. Thanks to the recent spectroscopic surveys targeting extra-galactic PNe, we can now rely on a few tens of galaxies where the kinematics of the stellar halos are measured. Here, I will review the main results obtained in this field in the last decades.
Using Expressive Arts Therapy to Develop Coping Mechanisms to Manage Substance Use

This paper examines past and current usages of expressive arts therapy in developing coping mechanisms for substance use recovery and explores possibilities for further integration in the adolescent and young adult population around the world. Abundant information is available on the effects of drugs and other substances on mental health, but more research is needed on how the integration of expressive arts therapy can enhance substance abuse programs for these populations. According to the CDC, elevated adverse effects on mental health occurred during the COVID-19 pandemic in the US with young adults reporting increased substance use (Czeisler et al., 2020). The integration of expressive arts therapy into programs can increase the awareness of its benefits and provide a wider range of options for coping with a substance use disorder (SUD). Current research shows a need for further investigation on how expressive arts therapy can be used to develop coping mechanisms for these populations. Research on the arts in action can be found separately but more information is needed on holistic integration of the expressive arts as many findings included dated short-term interventions utilizing one or two art forms on very narrow populations with little to no follow-up. This review examines existing practices and contributes toward a better understanding of developing coping mechanisms to manage substance use through expressive arts therapy.
Gravitational wave opacity from gauge field dark energy

We show that astrophysical gravitational waves can undergo an anomalous modulation when propagating through cosmic gauge field dark energy. A sufficiently strong effect, dependent on the gauge field energy density, would appear as a redshift-dependent opacity, thereby impacting the use of gravitational wave standard sirens to constrain the expansion history of the Universe. We investigate a particular model of cosmic gauge field dark energy and show that at early times it behaves like dark radiation, whereas a novel interaction causes it to drive cosmic acceleration at late times. Joint constraints on the cosmological scenario due to type 1a supernovae, baryon acoustic oscillations, and cosmic microwave background data are presented. In view of these constraints, we show that standard siren luminosity distances in the redshift range 0.5 < z < 1.5 would systematically dim by at most 1%.
Quantum Coarse-Graining: An Information-theoretic Approach to thermodynamics

We investigate fundamental connections between thermodynamics and quantum information theory. First, we show that the operational framework of thermal operations is nonequivalent to the framework of Gibbs-preserving maps, and we comment on this gap. We then introduce a fully information-theoretic framework generalizing the above by making further abstraction of physical quantities such as energy. It is technically convenient to work with and reproduces known results for finite-size quantum thermodynamics. With our framework we may determine the minimal work cost of implementing any logical process. In the case of information processing on memory registers with a degenerate Hamiltonian, the answer is given by the max-entropy, a measure of information known from quantum information theory. In the general case, we obtain a new information measure, the "coherent relative entropy", which generalizes both the conditional entropy and the relative entropy. It satisfies a collection of properties which justifies its interpretation as an entropy measure and which connects it to known quantities. We then present how, from our framework, macroscopic thermodynamics emerges by typicality, after singling out an appropriate class of thermodynamic states possessing some suitable reversibility property. A natural thermodynamic potential emerges, dictating possible state transformations, and whose differential describes the physics of the system. The textbook thermodynamics of a gas is recovered as well as the form of the second law relating thermodynamic entropy and heat exchange. Finally, noting that quantum states are relative to the observer, we see that the procedure above gives rise to a natural form of coarse-graining in quantum mechanics: Each observer can consistently apply the formalism of quantum information according to their own fundamental unit of information.
Updated constraints on non-standard neutrino interactions from Planck

We provide updated bounds on non-standard neutrino interactions based on data from the Planck satellite as well as auxiliary cosmological measurements. Two types of models are studied - A Fermi-like 4-point interaction and an interaction mediated by a light pseudoscalar - and we show that these two models are representative of models in which neutrinos either decouple or recouple in the early Universe. Current cosmological data constrain the effective 4-point coupling to be GX ⩽ (0.06 GeV)-2, corresponding to GX ⩽ 2.5 × 107 GF. For non-standard pseudoscalar interactions we set a limit on the diagonal elements of the dimensionless coupling matrix, gij, of gii ⩽ 1.2 × 10-7. For the off-diagonal elements which induce neutrino decay the bound is significantly stronger, corresponding to gij ⩽ 2.3 × 10-11(m/0.05 eV)-2, or a lifetime constraint of τ ⩾ 1.2 × 109 s (m/0.05 eV)3 . This is currently the strongest known bound on this particular type of neutrino decay. We finally note that extremely strong neutrino self-interactions which completely suppress anisotropic stress over all of cosmic history are very highly disfavored by current data Δ χ2 ∼ 104).
Dexmedetomidine compared to ketofol for sedation in pediatric patients undergoing dental procedures: a double-blind, randomized clinical trial

Background & objective: Hospital phobia and anxiety are still prevalent issues in the pediatric patients. Various sedative regimes have been in dental practice, but the evidence for safe and effective sedative drugs in this population is scarce. We compared the safety and efficacy of intravenous combination of ketamine plus propofol (ketofol) with dexmedetomidine (Dex) as a sedative premedication in anxious children undergoing dental pulp therapy. Methodology: This double-blind, randomized clinical study recruited 40 anxious children who were to undergo dental pulp therapy. The study participants were allocated into two groups (20 subjects each). Subjects in Group I received ketofol solution (ketamine/propofol mixture, each mL contains 2 mg of ketamine plus 4 mg of propofol). A loading dose of 0.3125 mL/kg was administered intravenously (IV) over 10 min, followed by maintenance infusion at a rate of 0.05-0.125 mL/kg/h. Subjects in Group II received the Dex solution (4 µg/mL). A loading dose of 2 µg/kg was administered IV over 10 min, followed by a maintenance infusion of 0.1-1 µg/kg/h. Non-invasive blood pressure, SpO2, heart rate (HR), and respiratory rate (RR) were assessed at baseline, at 2 min, and then at 5 min intervals till 60 min. Ramsay sedation score was assessed before, during, and after the procedure and Aldrete's recovery rating score was assessed at the end of the procedure. Results: Compared to the Dex group, the ketofol group showed a statistically significant shorter sedation onset (P = 0.017) but longer discharge time as well as higher rescue dose and a number of interruptions (P < 0.001). There was more stable respiration in Dex group, but with significantly more bradycardia. The mean arterial blood pressure showed some episodes of significant elevations with ketofol compared to Dex, while a biphasic response was observed in the Dex group. Conclusion: The use of Dex induced successful sedation of children who underwent tooth pulp therapy in terms of minimizing the number of interruptions during the procedure, the frequency of rescue drugs administration as well as the total procedure and discharge times. Dexmedetomidine showed no adverse respiratory effects but was associated with bradycardia and biphasic mean blood pressure alterations that require careful titration. Abbreviations: HR: heart rate; IV: Intravenous; RSS: NMDA: N-Methyl D-Aspartate PACU: Post Anesthesia Care Unit; Ramsay sedation score Citation: Hussien RM, Emam DF, Shoukry AA. Dexmedetomidine compared to ketofol for sedation in pediatric patients undergoing dental procedures: a double-blind, randomized clinical trial. Anaesth. pain intensive care 2022;26(5):595-601; DOI: 10.35975/apic.v26i5. 2016
A RARE EARLY-TYPE STAR REVEALED IN THE WING OF THE SMALL MAGELLANIC CLOUD

Sk 183 is the visually brightest star in the N90 nebula, a young star-forming region in the Wing of the Small Magellanic Cloud (SMC). We present new optical spectroscopy from the Very Large Telescope which reveals Sk 183 to be one of the most massive O-type stars in the SMC. Classified as an O3-type dwarf on the basis of its nitrogen spectrum, the star also displays broadened He i absorption, which suggests a later type. We propose that Sk 183 has a composite spectrum and that it is similar to another star in the SMC, MPG 324. This brings the number of rare O2- and O3-type stars known in the whole of the SMC to a mere four. We estimate physical parameters for Sk 183 from analysis of its spectrum. For a single-star model, we estimate an effective temperature of 46 ± 2 kK, a low mass-loss rate of ∼10−7 M☉ yr−1, and a spectroscopic mass of 46+9−8 M☉ (for an adopted distance modulus of 18.7 mag to the young population in the SMC Wing). An illustrative binary model requires a slightly hotter temperature (∼47.5 kK) for the primary component. In either scenario, Sk 183 is the earliest-type star known in N90 and will therefore be the dominant source of hydrogen-ionizing photons. This suggests Sk 183 is the primary influence on the star formation along the inner edge of the nebula.