Miracle-dz/UniFAR-FTUs huggingface dataset:
Up-regulation of Osh6 boosts an anti-aging membrane trafficking pathway toward vacuoles

Members of the family of oxysterol-binding proteins mediate non-vesicular lipid transport between membranes and contribute to longevity in different manners. We previously found that a 2-fold up-regulation of Osh6, one of seven yeast oxysterol-binding proteins, remedies vacuolar morphology defects in mid-aged cells, partly down-regulates the target of rapamycin complex 1 (TORC1), and increases the replicative lifespan. At the molecular level, Osh6 transports phosphatidylserine (PS) and phosphatidylinositol-4-phosphate (PI4P) between the endoplasmic reticulum (ER) and the plasma membrane (PM). To decipher how an ER-PM working protein controls vacuolar morphology, we tested genetic interactions between OSH6 and DRS2, whose protein flips PS from the lumen to the cytosolic side of the Golgi, the organelle between ER and vacuoles in many pathways. Up-regulated OSH6 complemented vacuolar morphology of drs2Δ and enriched PI4P on the Golgi, indicating that Osh6 also works on the Golgi. This altered PI4P-enrichment led to a delay in the secretion of the proton ATPase Pma1 to the PM and a rerouting of Pma1 to vacuoles in a manner dependent on the trans-Golgi network (TGN) to late endosome (LE) trafficking pathway. Since the TGN-LE pathway controls endosomal and vacuolar TORC1, it may be the anti-aging pathway boosted by up-regulated Osh6.
Electrospun Core–Sheath Nanofibers with Variable Shell Thickness for Modifying Curcumin Release to Achieve a Better Antibacterial Performance

The inefficient use of water-insoluble drugs is a major challenge in drug delivery systems. Core–sheath fibers with various shell thicknesses based on cellulose acetate (CA) were prepared by the modified triaxial electrospinning for the controlled and sustained release of the water-insoluble Chinese herbal active ingredient curcumin. The superficial morphology and internal structure of core–sheath fibers were optimized by increasing the flow rate of the middle working fluid. Although the prepared fibers were hydrophobic initially, the core–sheath structure endowed fibers with better water retention property than monolithic fibers. Core–sheath fibers had flatter sustained-release profiles than monolithic fibers, especially for thick shell layers, which had almost zero-order release for almost 60 h. The shell thickness and sustained release of drugs brought about a good antibacterial effect to materials. The control of flow rate during fiber preparation is directly related to the shell thickness of core–sheath fibers, and the shell thickness directly affects the controlled release of drugs. The fiber preparation strategy for the precise control of core–sheath structure in this work has remarkable potential for modifying water-insoluble drug release and improving its antibacterial performance.
Principais evidências clínicas da oxigenoterapia hiperbárica no tratamento de úlceras de pé diabético: uma revisão sistemática

Objetivo: Analisar as principais evidências clínicas acerca do uso da oxigenoterapia hiperbárica no tratamento de úlceras de pé diabético. Metodologia: Trata-se de uma revisão sistemática realizada por meio do método PRISMA, nas bases de dados eletrônicas PubMed, Scopus e Web of Science, por meio dos seguintes descritores: “hyperbaric oxygenation” “diabetes”, “diabetic foot”, “leg ulcer” e “ischemia” Foram incluídos textos completos, disponíveis em português, inglês ou espanhol, publicados entre janeiro de 2016 a dezembro de 2021; os estudos precisavam avaliar a proporção de pessoas com úlceras de pé diabético cicatrizadas completamente em participantes randomizados para oxigenoterapia hiperbárica e em um grupo controle. Resultados: 08 artigos compuseram a amostra final desse estudo, com maior frequência de publicação em 2019 (n: 03). Todas as pesquisas apresentaram a metodologia do Ensaio Clínico Randomizado, apresentando nível de evidência forte (II). No geral, identificou-se que a taxa de amputação nos pacientes submetidos a oxigenoterapia hiperbárica foi inferior em relação ao tratamento padrão estabelecido nos ensaios clínicos. Três estudos relataram a redução da área da úlcera e cinco estudos mostraram que a oxigenoterapia hiperbárica aumentou a taxa de cicatrização das úlceras de pé diabético em relação ao tratamento convencional, com resultados estatisticamente significantes. Conclusão: As evidências atuais mostram algumas evidências da eficácia da
Comparison of modified Glasgow-Imrie, Ranson, and Apache II scoring systems in predicting the severity of acute pancreatitis.

Aim: The course of acute pancreatitis is variable with patients at risk of poor outcomes. The purpose of this study was to compare Modified Glasgow-Imrie, Ranson, and APACHE II scoring systems in predicting the severity of acute pancreatitis. Material and Methods: After a brief history, clinical examination and qualifying inclusion criteria, 70 patients (41 women, 29 men) diagnosed with acute pancreatitis were included in the study. The three scores were calculated for each patient and evaluated for their role in the assessment of specific outcomes. Results: 34.3% patients were diagnosed with severe acute pancreatitis, while 65.7% patients had mild acute pancreatitis. A strong positive correlation was found between all the prognostic scores and the severity of disease. In the prediction of the severity of disease according to AUC, it was found that Glasgow-Imrie score had an AUC of 0.864 (0.7560.973), followed very closely by APACHE II score with an AUC of 0.863 (0.7580.968). APACHE II had the highest sensitivity (79.17%) in predicting severity while Glasgow-Imrie score was the most specific (97.83%) of all the scores. Patients with a Glasgow-Imrie score above the cut-off value of 3 had more complications and a longer hospital stay. Conclusion: The Glasgow-Imrie score was comparable to APACHE II score and better than Ranson score statistically in predicting the severity of acute pancreatitis. Its administration in predicting the severity of acute pancreatitis is recommended.
4877 - SURFACE PROFILE EVALUATION BY FRACTAL DIMENSION AND STATISTIC TOOLS

A lot of natural structures in industry applications can be hardly described by conventional methods – statistic tools, because they are complex and irregular. A relatively new approach is the application of fractal geometry that is successfully used in science, but an application in industry is sporadic and experimental only. However, the fractal geometry can be used as a useful tool for an explicit, objective and automatic description of production process data (laboratory, off-line and potential on-line). Industrial data (from production processes, quality control, production tools, etc.) may have a form of digitalized pictures, time series or a topologically one-dimensional interface (especially a surface roughness or a surface profile). The data in a digital form can be described by the fractal geometry, which expressing the complexity degree of structured data (ideally) by means of a single number, the fractal dimension. On this account, we are developing three off-line software tools that can be converted to on-line control tools in the future. The article is intended only on application of the fractal geometry with combination of statistic tool for the classification of dividing lines (a surface profile or a surface roughness evaluation) with example from glass industry.
Validation of single‐station lightning location technique

Lightning discharges are powerful impulsive sources of electromagnetic energy over a wide bandwidth allowing passive methods to determine lightning location through the energy released by the lightning discharge. While multistation lightning location techniques provide high location accuracy, in some instances it is impossible to deploy a multistation network, and for this reason, techniques have been developed to allow single‐station lightning location. We consider the validation of the “Kharkov” single‐station lightning location method proposed by Rafalsky et al. [1995a] , through comparing the locations of ELF/VLF observed sferics determined by the Kharkov technique with the positions of coincident lightning flashes recorded by a commercial lightning detection network. Making use of 85 sferics observed at Robertson Army Barracks, near Darwin, Australia, in the period from 20 November 1997 until 7 January 1998, we find that that ∼68% of Kharkov method bearing estimates are accurate to within 4.1° and that ∼68% of the Kharkov method range estimates are accurate to within 73.2 km.
Phytochemical Analysis and Molecular Identification of Green Macroalgae Caulerpa spp. from Bali, Indonesia

The studies of the Bulung Boni and Bulung Anggur (Caulerpa spp.) species and secondary metabolites are still very limited. Proper identification will support various aspects, such as cultivation, utilization, and economic interests. Moreover, understanding the secondary metabolites will assist in developing algae-based products. This study aimed to identify these indigenous Caulerpa algae and analyze their bioactive components. The tufA sequence was employed as a molecular marker in DNA barcoding, and its bioactive components were identified using the GC-MS method. The phylogenetic tree was generated in MEGA 11 using the maximum likelihood method, and the robustness of the tree was evaluated using bootstrapping with 1000 replicates. This study revealed that Bulung Boni is strongly connected to Caulerpa cylindracea. However, Bulung Anggur shows no close relationship to other Caulerpa species. GC-MS analysis of ethanolic extracts of Bulung Boni and Bulung Anggur showed the presence of 11 and 13 compounds, respectively. The majority of the compounds found in these algae have been shown to possess biological properties, such as antioxidant, antibacterial, anticancer, anti-inflammation, and antidiabetic. Further study is necessary to compare the data obtained using different molecular markers in DNA barcoding, and to elucidate other undisclosed compounds in these Caulerpa algae.
The Distribution and Function of Virtual Reflexive Constructions in English

This paper sheds new light on the distributional and functional properties of virtual reflexive constructions (VRCs) in English (e.g., This problem solves ITSELF). VRCs describe the level of ease involved in performing the action denoted by the verb. They typically involve metaphorical interpretations, are compatible with adverbs such as virtually, and obtain a primary stress on the reflexive pronoun object. Two claims are presented in this paper: first, the subject of VRCs can be regarded as a crucial contributing factor (i.e., an essential factor in a causal relation). This analysis explains the metaphorical interpretations of VRCs, their compatibility with adverbs such as virtually, and the primary emphasis placed on the reflexive pronoun object. Second, VRCs typically act as anticausativizing causative verbs with no anticausative alternants via metaphor. Namely, VRCs express metaphorical anticausative situations. Causative verbs that can alternate with intransitive anticausative verbs (e.g., break, open, melt) tend to prefer the intransitive anticausative usage when describing anticausative situations (e.g., the vase broke) because intransitive anticausatives are simpler in form and less marked than VRCs. On the other hand, causative verbs with no anticausative alternant (e.g., write, sell) are more likely to occur in VRCs when describing anticausative situations. In other words, VRCs enable these causative verbs to express metaphorical anticausative situations. This analysis is supported by a corpus-based investigation.
Detection of virulence factor encoding genes on Escherichia coli isolated from broiler chicken in Blitar District, Indonesia

Abstract. Efendi MH, Faridah HD, Wibisono FM, Wibisono FJ, Nisa N, Fatimah F, Ugbo EN. 2022. Detection of virulence factor encoding genes on Escherichia coli isolated from broiler chicken in Blitar District, Indonesia. Biodiversitas 23: 3437-3442. Broiler chicken is a source of protein that is widely consumed by the public. However, broiler chicken production sometimes decreases due to infectious diseases such as colibacillosis caused by pathogenic Escherichia coli possessing virulence genes. Virulence factors function to facilitate colonization and invasion of host cells to cause disease. The presence of these virulence factors is encoded by various genes such asthe increased serum survival gene and P fimbriae gene which plays a role in surface adhesion. The present study aims to detect the presence of virulence genes from extended-spectrum beta-lactamase (ESBL) producing E.coli isolated from broiler chickens in the Blitar District. A total of 110 cloacal swabs collected by systematic random sampling from broiler poultry farms in four different sub-districts were screened for ESBL-producing E. coli and virulence genes by phenotypic and molecular methods, respectively. Out of 110 E.coli recovered, 95 (86.4%) were observed to show a high level of resistance to the tested antibiotics, and 34 (35.7%) were ESBL-producers. Among ESBL producing E. coli isolates, 22 (73.5%) and 1 (2.9%) were found to have the iss and papC gene virulence factors, respectively using the polymerase chain reaction (PCR) method. The results of this study indicate that virulence genes can be found in E. coli from poultry farms. The iss gene is the most predominant virulence gene. The reportof these virulence factors in E. coli isolated from broiler could impose a serious potential public health problem.
WSRT and VLA observations of HI in the direction of 3C-10

Westerbork Synthesis Radio Telescope HI observations combined with Effelsberg 100 m antenna observations have been made of the galactic supernova remnant 3C 10 (Tycho) with an angular resolution similar or equal to 50 '' and a velocity resolution of 0.62 km s(-1) and with the VLA with resolutions of similar to 13 '' and 1.3 km s(-1), respectively. HI absorption against 3C 10 was detected in the velocity range -60 less than or equal to v less than or equal to 10 km s(-1). The most negative velocity component is at -57 km s(-1). HI absorption in the direction of extragalactic source 3C11.1 and two additional sources close to 3C 10 (distance less than or similar to 1 degrees) was obtained using the Very Large Array. Comparison of the spectra together with two other sources from Taylor and Roberts (1993) (distance less than or similar to 2 degrees) leads to the conclusion that 3C 10 is at a distance of 4.5 kpc. The implications of this distance are discussed. The HI absorption at -48 km s(-1) in the direction of 3C 10 shows a filament of size similar to 4'. Self-absorption near 3C 10 is also detected at this velocity, and an upper limit of 25 K for the spin temperature can be derived. A comparison with a high resolution 100 mu. IRAS image is discussed. The HI absorption at low velocities (-20 less than or equal to v less than or equal to +10 km s(-1)) shows primarily large scale structure. For this gas a spin temperature of 75 K can be derived. All distances are based on R. = 8.5 kpc.
A review of movement models in open population capture–recapture

Understanding rates of survival and recruitment is critical to population management, and capture–recapture methods of estimation are widely used. Spatial models allow for a spatial detection process and can include the movement of activity centres between sampling times. Movement is often treated as a random walk with the step length governed by a probability kernel. However, the movement component of open population spatially explicit capture–recapture models (open SECR) has evolved haphazardly and comparison among studies is difficult. We review published studies, document suitable probability kernels and address the issues of scale and buffer dependence in open SECR by a combination of simulation and case studies on ovenbirds Seiurus aurocapilla and tigers Panthera tigris. Flexible 2‐parameter kernels, such as the bivariate t ‐distribution, fit better than the popular bivariate normal and resulted in higher estimates of survival. We reconcile different parameterizations of the bivariate t ‐distribution and identify a problem when the kernel is defined in terms of its margins. Movement models failed to separate mortality and emigration in simulated data when the data were a random mixture of long and short movements. Our estimates of ovenbird survival were buffer‐dependent, and we interpret this as a sign that the data are inadequate for joint modelling of survival and movement. Estimates of tiger survival were more nearly asymptotic on buffer width. We repeat the warning of earlier authors that movement models are effective for separating mortality and emigration only when the data span the range of movement. We appeal for more complete and consistent reporting of movement models and identify topics for future research.
Number of bonds in the site-diluted lattices: sampling and fluctuations

We have calculated analytically the mean value and the variance of the number of bonds on the lattices of dimension $d$ for the given occupation of sites. We consider both kinds of site occupation: with the fixed concentration $n_s$ of occupied sites and with the probability $p$ for a site to be occupied. We found that the variance are smaller in the former case and not depends from the dimensionality of the hypercubic lattice. Whereas in the last case it grows with the space dimensionality. The ratio of variances are quite different in the limit of $p\to 1$. Finally, we demonstrate the relevance of the level of fluctuations on the precision of energy calculations for the Ising model in the Monte Carlo simulations.
Numerical analysis of viscoelastic Maxwell fluid flow through a radiative axisymmetric semi‐porous channel

The non‐Newtonian fluids have abundant implications in versatile fields of chemical, mechanical, and biological engineering. Furthermore, the non‐Newtonian fluids flowing through the porous medium are very useful in petroleum and industrial engineering. Heat transport analysis with radiation has major appliances in fusion reactors, heat exchangers, solar energy, aircrafts engines, turbine cooling, and many others. Having all these important appliances in view, the present study is focused on the heat transfer analysis of an incompressible two‐dimensional viscoelastic magnetohydrodynamic Maxwell non‐Newtonian liquid flow in a porous space. The magnetic field is uniformly applied tangential to the flow direction and the lower‐channel wall is heated by induction as a consequence of the Lorentz force. The effect of thermal radiation is taken to foresee the physical occurrence of heat kinetics from an applied point of view. Similarity transformation is considered in reducing the governing partial differential equations into ordinary differential equations and a numerical solution is computed using the shooting technique. The results obtained are compared with the published literature. The effects of flow quantities are illustrated graphically and analyzed with physical meaning. In view of engineering applications, the effects of Reynolds on skin friction coefficient and rate of heat transfer are presented.
The Effects of High-Intensity Power Training versus Traditional Resistance Training on Exercise Performance

Background: High-intensity interval training (HIIT) features short, repeated bursts of relatively vigorous exercise with intermittent periods of rest or low-intensity exercise. High-intensity power training (HIPT), in combination with HIIT and traditional resistance training (TRT), is characterized as multijoint high-intensity resistance exercises with low interset rest periods. HIPT requires people to finish the exercise as fast as possible, which increases acute physiological demands. The aim of the study was to investigate the differences between eight-week HIPT or TRT on exercise performance. Methods: Twenty-four college students were recruited and randomly assigned to either the HIPT or TRT group in a counterbalanced order. The power of upper and lower limbs (50% 1RM bench press and vertical jump) and anaerobic power were tested before and after the training (weeks 0 and 9). The results were analyzed by two-way analysis of variance (ANOVA) or Friedman’s test with a significance level of α = 0.05 to compare the effects of the intervention on exercise performance. Results: There were significant differences in the explosive force of the upper and lower limbs between the pretest and post-test in both the HIPT and TRT groups (p < 0.05). However, only the HIPT group showed a significant difference in the mean power on the Wingate anaerobic test between the pretest and post-test (p < 0.05). Conclusions: Both HIPT and TRT can improve upper and lower limb explosive force. HIPT is an efficient training protocol, which took less time and produced a better improvement in mean anaerobic power.
Influence of Transfer Entropy in the Short-Term Prediction of Financial Time Series Using an ∊-Machine

Predicting the values of a financial time series is mainly a function of its price history, which depends on several factors, internal and external. With this history, it is possible to build an ∊-machine for predicting the financial time series. This work proposes considering the influence of a financial series through the transfer of entropy when the values of the other financial series are known. A method is proposed that considers the transfer of entropy for breaking the ties that occur when calculating the prediction with the ∊-machine. This analysis is carried out using data from six financial series: two American, the S&P 500 and the Nasdaq; two Asian, the Hang Seng and the Nikkei 225; and two European, the CAC 40 and the DAX. This work shows that it is possible to influence the prediction of the closing value of a series if the value of the influencing series is known. This work showed that the series that transfer the most information through entropy transfer are the American S&P 500 and Nasdaq, followed by the European DAX and CAC 40, and finally the Asian Nikkei 225 and Hang Seng.
An “Alternative to the Pen”? Perspectives for the Design of Historiographical Videogames

This article presents how the tools of videogame design can be used to convey historical arguments, and to what extent historians could benefit from creating such videogames. We begin by positioning our argument within the literature on the writing of history, linking it to formal and writing issues, which leads us to delve into various definitions of what “videogames for history” could be, and what operational frameworks could be derived from those definitions. We then confront some key principles of design to a selection of actual videogame projects to discuss the possibility of “historiographical game design” to be considered as “an alternative to the pen” (Chapman, 2013, p. 329) for historians. Our goal is to identify general principles in the design of historiographical videogames, to provide an improved and refined definition of these games from a design perspective and to formulate general guidelines to inform further explorations through research-creation projects.
SSPECIALREG: Stata module to estimate binary choice model with discrete endogenous regressor via special regressor method

sspecialreg estimates a binary choice model that includes one or more endogenous regressors using Lewbel and Dong's special regressor method (Econometric Reviews, 2015; Journal of Econometrics, 2000). This assumes that the model includes a particular 'special regressor', V, that is exogenous and appears additively in the model. It must be continuously distributed with a large support. A special regressor with thick tails (greater kurtosis) will be more useful as a special regressor. This method has advantages over the linear probability model (estimated with OLS or IV), maximum likelihood and control function methods. The xtspecialreg command estimates the model in a panel data setting, with the data xtset or tsset.