Miracle-dz/UniFAR-FTUs huggingface dataset:
Synthesis of Successful Bicycle Planning in Mid-Size Cities

The Texas Tech Center for Multidisciplinary Research in Transportation worked together with the Texas Department of Transportation to conduct a survey of successful bicycle policies and practices in the United States. The team developed and released an online survey targeted at various groups including Metropolitan Planning Officials, government officials, bicycle users, bicycle advocacy groups, Texas Department of Transportation (TxDOT) employees, and TexITE members. The purpose of this survey was to rate various issues of funding, safety, and organization to create a clear picture of how successful bicycling would appear in Texas, particularly in mid-size cities. Although it is gaining popularity as a means of transportation, bicycling has historically been underutilized in the United States. The federal transportation funding program in the United States has focused on highway construction and maintenance for automotive travel. As a result, many U.S. cities have been developed with very little thought for the use of bicycling for recreation or travel. Insufficient and badly-designed bicycle facilities have caused many problems, including insufficient access, insufficient street markings, limited right-of-way, discontinuity, or heavily motorized vehicle traffic on bike paths. These challenges make it difficult for bicyclists to properly access and use the necessary facilities. The goal of this research project was to synthesize successful practices of bicycle planning in mid-size cities, including reviews of bicycle practices in the U.S. and successful experiences in planning, design, and implementation of bicycle facilities, conduct a survey of successful bicycle policies and practices in the U.S., and identify common problems in bicycling and key factors for promoting bicycling transportation. Key findings include that funding, culture, education, and engineering are equally important for promoting bicycling; funding and consistent commitment is the primary issue for transportation agencies while safety is the primary concern for bicyclists; there are few differences between city sizes for bicycle users and government officials; and that it is likely that bike plans are underutilized in mid-size cities. The research team suggests that the following actions be taken to properly plan and implement effective bicycle strategies: long-range and short-term transportation plans should be made with an aim at building livable societies in which bicycling is given dual consideration with automobile travel; local government agencies should be responsible for developing the bicycle plan and should be given authority to use federal funding for financing bicycle projects; mid-sized cities should have at least one bicycle coordinator employed by the city or local metropolitan planning organization (MPO); and state and local transportation agencies should be aware that promoting bicycling is a long-range endeavor which requires continuous funding support and coordinated planning, design, and maintenance efforts.
In the hands of users with Learning Disabilities: Co-Designing Tangible Users Interfaces for Mental Wellbeing

Involving and engaging people with learning disabilities on issues relating to their mental wellbeing can bechallenging. This research explores how participatory design techniques and principles can be used to engagepeople with learning disabilities in designing technological solutions relevant to them that could monitorand aid their mental wellbeing. Specifically, we explore methods used in a series of co-design workshopsto engage people with learning disabilities in the use of tangible interfaces for mental wellbeing. A varietyof designs, sensors and interventions were explored during the workshops resulting in the development ofmultiple mental wellbeing interfaces. Furthermore, data collection trials using the developed interfaces havedemonstrated the potential to collect real-world labelled data that can be used to train machine learningclassifiers. The co-design approach adopted for the design of the mental wellbeing tangible interfaces ensuredthat effective and suitable devices have been developed
Peritumoral ductular reaction can be a prognostic factor for intrahepaticcholangiocellular carcinoma

Background: Peritumoral ductular reaction (DR) was reported to be related to the prognosis of combined hepatocellular-cholangiocarcinoma and hepatocellular carcinoma. Non-mucin-producing intrahepatic cholangiocarcinoma (ICC) which may be derived from small bile duct cells or liver progenitor cells (LPCs) was known to us. However, whether peritumoral DR is also related to non-mucin-producing ICCs remains to be investigated. Methods: Forty-seven patients with non-mucin-producing ICC were eventually included in the study and clinicopathological variables were collected. Immunohistochemical analysis and immunofluorescence staining for cytokeratin 19, proliferating cell nuclear antigen, and α-smooth muscle actin were performed in tumor and peritumor liver tissues.Results: A significant correlation existed between peritumoral DR and local inflammation and fibrosis. (r = 0.357, 95% CI, 0.037-0.557; P = 0.008 and r = 0.742, 95% CI, 0.580-0.849; P < 0.001, respectively). Patients with obvious peritumoral DR had high recurrence rate (81.8% vs 56.0%, P = 0.058) and poor overall and disease-free survival time (P = 0.01 and P = 0.03, respectively) comparing with mild peritumoral DR. Compared with the mild peritumoral DR group, the proliferation activity of LPCs/ cholangiocytes was higher in obvious peritumoral DR, which, however, was not statistically significant. (0.43±0.29 vs 0.28±0.31, P = 0.172). Furthermore, the correlation analysis showed that the DR grade was positively related to the portal/septalα-SMA level (r = 0.359, P = 0.001). Conclusions: Peritumoral DR was associated with local inflammation and fibrosis. Patients with non-mucin-producing ICC having obvious peritumoral DR had a poor prognosis. Peritumoral DR could be a prognostic factor for ICC. However, the mechanism should be further investigated.
Evaluate on substrates for mass production of entomopathogenic fungus Beauveria bassiana (Balsamo)

The present investigation entitled “Mass Production of entomopathogenic fungai Beauveria bassiana (Metsch.) on liquid and solid media” was carried out at Bio Control Laboratory, Department of Entomology, Sardar Vallabhbhai Patel University of Agriculture and Technology, Meerut during 2018-19. In all there were eight treatments including control replicated thrice in a randomized block design. The results obtained in the study are summarized. The effect of different substrates for the mass production of Beauveria bassiana spore/ml was significantly higher recorded. Data recorded on 7, 14, 21, 28, 35 after the day after inoculation of various treatments in the, T10 Savoured dextrose broth (SDB), was the best treatment by bringing down the B. Bassiana production up to (49.48) spore/ml in liquid medium during the 2018-19 years. The other treatments in order of spore producing was with T11 Potato dextrose broth (PDB) (38.52), in liquid medium and solid medium in the treatment and T8 Cowpea Vigna unguiculata + Molasses + 1% YE + 1.0 g Dextrose (28.73), followed by with T7 Black gram Vigna mungo + Molasses + 1% YE + 1.0 g Dextrose (27.52 spore/ml, T5 Cowpea Vigna unguiculata + Molasses + 1% YE (17.53 spore/ml), T4 Black gram Vigna mungo + Molasses + 1% YE (14.87 spore/ml), T2 Cowpea Vigna unguiculata + Molasses (10.50 spore/ml), T1 Black gram Vigna mungo + Molasses (8.35 spore/ml), T9 Gram Cicer aeritinum + Molasses + 1% YE + 1.0 g Dextrose (3.92 spore/ml), T6 Gram Cicer aeritinum + Molasses + 1% YE (2.85 spore/ml) and T3 Gram Cicer aeritinum + Molasses respectively.
Costs and Emissions Reductions from the Competitive Renewable Energy Zones (CREZ) Wind Transmission Project in Texas

Wind power has the potential to significantly reduce air emissions from the electric power sector, but the best wind sites are located far from load centers and will require new transmission lines. Texas currently has the largest installed wind power capacity in the U.S., but a lack of transmission capacity between the western part of the state, where most wind farms are located, and the major load centers in the east has led to frequent wind curtailments. State policymakers have addressed this issue by approving a $5 billion transmission project, the Competitive Renewable Energy Zones (CREZ), which will expand the transmission capacity to 18,456 MW by 2014. In this paper, we examine the impacts of large-scale wind power in ERCOT, the power market that serves 85% of the state’s load, after the completion of the CREZ project. We assess the generation displaced and the resulting emissions reductions. We then examine the public costs of wind to estimate the CO2 abatement cost. We develop an economic dispatch model of ERCOT to quantify the generation displaced by wind power and the emissions reductions in 2014. Since there is uncertainty about the amount of new wind developed between now and 2014, three wind penetration scenarios were assessed that correspond to wind supplying 9%, 14% and 21% of ERCOT’s total generation. In the 21% wind energy penetration scenario, the CREZ transmission capacity is fully utilized, and wind displaces natural gas 74% of the time and coal 26% of the time. This results in CO2, NOX, SO2 and Hg emissions reductions of 19%, 17%, 13%, and 15%, and a CO2 abatement cost of $60 per ton of CO2. Lower wind penetrations result in gas being displaced more frequently, lower emissions reductions and an abatement cost up to $91 per ton of CO2. Our results should be compared with other technologies and policies so that policymakers can costeffectively reduce emissions.
Leading the Organisation to Learn: The 10 Levers for Putting Knowledge and Learning to Work

Organisations that continue to learn and diffuse collective knowledge throughout their company are the most successful organisations of the 90s. This book shows you how to implement organisational learning in your company; today. The "learning organisation", "knowledge management", "intellectual capital": these are key words, words which are finding their way into every popular business journal, magazine and newspaper. Plus, key thinkers are now arguing that knowledge is an organisation's only sustainable competitive advantage. The successful organisations of today and tomorrow are those that can capture and harness knowledge. These are the learning organisations. Executives, managers and strategic thinkers are looking for ways to increase organisational learning. Leading the Organisation to Learn bridges the gap; providing a 10-step model and supporting processes to put the theory into practice. Author : Mick Cope is organisational development manager for BT. He is a popular speaker at conferences and has had many papers published on organisational learning and change management.
Hybrids of Thiazolidin-4-Ones and 1,3,4-Thiadiazole: Synthesis and Biological Screening of A Potential New Class of Acetylcholinesterae Inhibitors

Using propanoic acid and thiosemicarbazide as starting materials, a new sequence of thiazolidin-4-one analogs with thiadiazole derivative was synthesized in appreciable yield. Spectral techniques such as IR, 1H NMR, 13C NMR, and MS were used to validate the structures of the synthesized compounds (4a-t). In vitro acetylcholinesterase inhibitory activity of these synthesized compounds was assessed using an Ellman's method spectrophotometer and donepezil as a standard drug. Compounds 2-((5-ethyl-1,3,4-thiadiazol-2-yl)imino)-5-(4-methylbenzylidene)thiazolidin-4-one(4o) and 5-(4-(benzyloxy)benzylidene)-2-((5-ethyl-1,3,4-thiadiazol-2-yl)imino)thiazolidin-4-one(4i) were found to be potent AChE enzyme inhibitors, with pIC50 (mM) values of 1.30±0.007 and 1.22±0.002, respectively. Finally, these significant results could pave the way for the development of new AChE inhibitors and will serve as the basis for future research.
A Critical State of Multiple Simultaneous Link Disruptions

Links of a transportation network are subject to several forms of frequent non-severe disruptions like traffic incidents, snowing, flooding, road-space reallocations, road-space infiltrations, infrastructural failures, etc. Disregarding the cause, they may be viewed as multiple simultaneous disruptions on links’ capacities. Though the disruption or failure of a single link is widely studied, the area of multiple simultaneous disruptions on transportation networks is under-researched. Also, most of the existing studies assume probability distributions of capacity disruptions to be known. The objective of this paper is to study multiple simultaneous disruptions and to establish a consequent critical state. The authors assign different levels on links’ capacities and search for probability distributions over those levels that would result in a critical state. The critical state is modeled as the one which effects in poor network performance, and comparably equal expected path costs, that makes it hard for a user to identify the better path (i.e. it induces maximum indifference on expected utilities of alternative paths). The authors formulate the critical state link disruption problem as a minimax optimization problem, and solve it using a coevolutionary algorithm. The authors evaluate network performance in terms of expected system travel time. The formulation is exemplified by finding expected system travel time at the critical state on test networks. It is also shown how the performance at critical state can be used to measure network robustness.
Routing with Energy Threshold for WSN-IoT Based on RPL Protocol

Internet of Things (IoT) enables things to have connectivity through the internet. The number of things is growing fast and has to be uniquely identified through the Internet to communicate with other things. In Wireless Sensor Networks (WSNs) each node can be considered as a thing. WSN node resources are very limited due to the need to communicate using low power and usually through unreliable links. Such limitations need an energy efficient routing protocol. WSN is considered as a type of Low power and Lossy Network (LLN). The routing protocol for low power and lossy network (RPL) is being adopted for LLN and has been standardized to enable connectivity of WSN over IoT. RPL constricted a topology similar to tree topology. Nodes in RPL optimized its path using an objective function (OF). OF depends on different node/link metrics in the optimization process. In this paper, an Energy Threshold RPL (ETRPL) protocol is proposed. ETRPL depends on a new objective function to enhance energy consumption of RPL protocol by taking into account the remaining energy of the preferred parent node. ETRPL is implemented using Cooja simulator. The results show that ETRPL provides an increase in the remaining energy of at least 87.4% for a small area with high number of nodes. ETRPL also performed better with regards to Time Delay, Packet Reception Ratio, and the number of dead nodes in a small area. For a large area, the performance is not encouraging. Thus the proposed ETRPL protocol is useful for IoT networks with relatively small areas.
Collective urban design : shaping the city as a collaborative process

This book deals with two urban design issues: City Planning and Architectural Design. The relationship between these two issues has been regarded as an 'eternal' topic in the domain of urban design. The book offers a method to create a harmonious, individual and environmentally friendly collective form, through a collaborative design process. In order to achieve this purpose, civil engineers, city planners and architects have to work together, sharing a common object. The Master Architect Design Collaboration Method, which is studied mainly in this book, is a design method to create mixed types of collective forms. This method can be used for urban renewal projects and urban development projects. To understand the design process and method, the following is discussed: the issue of collective form creation and its history, design coordination, design communication and design development. Finally, the book discusses the urban design method from a practical point of view. This book is aimed at people working in public sectors, building engineers, city planners, architects and students and contributes to the making of urban design strategies and the carrying out of urban design processes.
An Examination of Kaizen Drift in Japanese Genba

II ACKNOWLEDGEMENTS IV LIST OF FIGURES X LIST OF TABLES X ATTESTATION OF AUTHORSHIP XI BIOGRAPHY XII CHAPTER ONE: INTRODUCTION 13 1.1 KAIZEN AND ITS INTERPRETATION IN THE ANGLOSPHERE 13 1.2 EMERGENCE OF THE QUALITY MOVEMENT 15 1.2. 1 Genba is All 16 1.2. 2 Kaizen Diffusion 16 1.2. 3 Intergenerational Diffusion of Kaizen 17 1.2. 4 Kaizen Drift 18 1.3 RESEARCH QUESTIONS 18 1.4 OVERVIEW OF RESEARCH METHOD 20 1.5 THESIS OUTLINE 22 1.6 DEFINITIONS 23 CHAPTER TWO: LITERATURE REVIEW 29 2.
Iron curtains : gates, suburbs, and privatization of space in the post-socialist city

List of Illustrations and Tables viii Series Editors Preface xi Acknowledgements xii 1 Introduction 1 2 Public, Private, Privatism 14 3 The Post-socialist City 34 4 Post-modern Urbanism Revisited 60 5 Sofia: Wither the Socialist City 81 6 The Ninth Ring: Suburbanizing Sofia 105 7 Iron Curtains I: Gated Homes 131 8 Iron Curtains II: Gated Complexes 149 9 Architecture of Disunity 170 10 Possibilities 191 References 198 Index 220
A clinical and in-silico study exploring the association of CASP-3, NF-kB, miR-187, and miR-146 in pre-eclampsia

ABSTRACT Introduction Apoptosis is involved in pathogenesis of Pre-eclampsia (PE), further research is needed to determine its molecular mechanism. Methods The study recruited two groups (controls; 09, PE; 11). Biochemical tests, RT-PCR and ELISA were employed for analysis of genes and MicroRNAs (miRNA). Bioinformatics tools were employed for interactomics analysis. Results There was increased apoptosis in maternal placental tissue (MPT) and Maternal Blood Cells (MBC) as demonstrated by expression of CASP3 and NF-κB1. miR-146-5p and 187-5p were downregulated in MBC and MPT but upregulated in fetal placental tissue (FPT). Discussion An increased apoptosis in MBC and MPT is a significant contributory factor for PE in pregnancy, while FPT is immune to the aforementioned effects. Graphical abstract
SOX10 Regulates Melanoma Immunogenicity through an IRF4–IRF1 Axis

This study identifies a novel SOX10/IRF4 pathway that regulates noncanonical induction of IRF1 independent of the JAK–STAT pathway and can be targeted to improve the efficacy of anti-PD-1 therapy in melanoma. Loss-of-function mutations of JAK1/2 impair cancer cell responsiveness to IFNγ and immunogenicity. Therefore, an understanding of compensatory pathways to activate IFNγ signaling in cancer cells is clinically important for the success of immunotherapy. Here we demonstrate that the transcription factor SOX10 hinders immunogenicity of melanoma cells through the IRF4–IRF1 axis. Genetic and pharmacologic approaches revealed that SOX10 repressed IRF1 transcription via direct induction of a negative regulator, IRF4. The SOX10–IRF4–IRF1 axis regulated PD-L1 expression independently of JAK–STAT pathway activity, and suppression of SOX10 increased the efficacy of combination therapy with an anti-PD-1 antibody and histone deacetylase inhibitor against a clinically relevant melanoma model. Thus, the SOX10–IRF4–IRF1 axis serves as a potential target that can bypass JAK-STAT signaling to immunologically warm up melanoma with a "cold" tumor immune microenvironment. Significance: This study identifies a novel SOX10/IRF4 pathway that regulates noncanonical induction of IRF1 independent of the JAK–STAT pathway and can be targeted to improve the efficacy of anti-PD-1 therapy in melanoma.
Longitudinal survival trends of patients with cancer with surgically managed appendicular metastatic bone disease: systematic review

Background: Advances in systemic cancer therapies have improved survival for patients with metastatic carcinoma; however, it is unknown whether these advances have translated to improved survival for patients with appendicular metastatic bone disease (A-MBD) after orthopedic interventions. We conducted a study to evaluate the trend in overall survival for patients who underwent orthopedic surgery for A-MBD between 1968 and 2018. Methods: A systematic search of Embase and Medline to identify studies published since 1968 evaluating patients treated with orthopedic surgery for A-MBD was conducted for a previously published scoping review. We used a meta-regression model to assess the longitudinal trends in 1-, 2- and 5-year overall survival between 1968 and 2018. The midpoint year of patient inclusion for each study was used for analysis. We categorized primary tumour types into a tumour severity score according to prognosis for a further meta-regression analysis. Results: Of the 5747 studies identified, 103 were retained for analysis. Meta-regression analysis showed no significant effect of midpoint study year on survival across all time points. There was no effect of the weighted average of tumour severity scores for each study on 1-year survival over time. Conclusion: There was no significant improvement in overall survival between 1968 and 2018 for patients with A-MBD who underwent orthopedic surgery. Orthopedic intervention remains a poor prognostic variable for patients with MBD. This finding highlights the need for improved collection of prospective data in this population to identify patients with favourable survival outcomes who may benefit from personalized oncologic surgical interventions.
Verbal and oral apraxia in patients with acute stroke: Frequency, relationship, and some risk factors.

Verbal and oral apraxia are two possible consequences of stroke. It seems that there are not sufficient studies regarding the frequency of these disorders. This study aimed to evaluate the frequency of Verbal and oral apraxia. In addition, the relationship between apraxia and some variables such as age, gender, and education, as well as the relationship between types of apraxia with each other, and damaged areas of the brain in apraxia of the oral system in Persian-speaking patients with stroke were studied. In this descriptive-analytical study, 42 patients participated using the convenient sampling method. Verbal and oral apraxia were assessed using the oral and verbal apraxia tasks for adults test. Data were analyzed using independent t-test, Chi-square, and Fisher's exact test. The frequency of patients with oral apraxia was 35.7%, those with verbal apraxia was 2.3%, and the combination of both verbal and oral apraxia was 4.7%. People with apraxia were significantly older than those without apraxia. There was not any significant relationship between apraxia and gender, apraxia and education, and oral apraxia with verbal apraxia (p < 0.05). The present study's findings showed the high frequency of post-stroke apraxia and the high rate of its incidence with age.
The comfort assessment in healthy adults during constant‐flow mode in noninvasive ventilator

From the point of view of machine construction and hydrodynamics, this paper innovatively proposes that the essence of high‐flow nasal cannula (HFNC) is a constant‐flow mode in noninvasive ventilator (NIVCFM). This study enrolled healthy adults as study subjects to assess the subjective comfort assessed by visual analog scoring scale of NIVCFM/HFNC and objective comfort measured by the noise level generated by NIVCFM/HFNC, aiming to provide a scientific basis for the rational clinical application of NIVCFM/HFNC.