Miracle-dz/UniFAR-FTUs huggingface dataset:
For Whom Does Determinism Undermine Moral Responsibility? Surveying the Conditions for Free Will Across Cultures

Philosophers have long debated whether, if determinism is true, we should hold people morally responsible for their actions since in a deterministic universe, people are arguably not the ultimate source of their actions nor could they have done otherwise if initial conditions and the laws of nature are held fixed. To reveal how non-philosophers ordinarily reason about the conditions for free will, we conducted a cross-cultural and cross-linguistic survey (N = 5,268) spanning twenty countries and sixteen languages. Overall, participants tended to ascribe moral responsibility whether the perpetrator lacked sourcehood or alternate possibilities. However, for American, European, and Middle Eastern participants, being the ultimate source of one’s actions promoted perceptions of free will and control as well as ascriptions of blame and punishment. By contrast, being the source of one’s actions was not particularly salient to Asian participants. Finally, across cultures, participants exhibiting greater cognitive reflection were more likely to view free will as incompatible with causal determinism. We discuss these findings in light of documented cultural differences in the tendency toward dispositional versus situational attributions.
E-commerce - Quais ícones e metáforas são a alma do negócio?

Diferenças culturais podem afetar a maneira como indivíduos percebem e atribuem significados aos ícones e metáforas. O uso apropriado de metáforas e ícones significativos e identificáveis pode reduzir a complexidade, aumentando a usabilidade; e devem ser usados ao se projetar sites de e-commerce. Se o site for para uso de clientes internacionais, as diferenças culturais devem ser consideradas. O mesmo conjunto de ícones de um estudo americano foi testado com brasileiros. Depois, um novo conjunto, formado por ícones de sites brasileiros, foi testado com brasileiros. Encontraram-se discrepâncias. Então, construiu-se um protótipo com os ícones mais significativos; realizaram-se testes com usuários para se determinar um conjunto de ícones mais facilmente "identificáveis".
Why the Crackling Deformations of Single Crystals, Metallic Glasses, Rock, Granular Materials, and the Earth's Crust Are So Surprisingly Similar

Recent experiments show that the deformation properties of a wide range of solid materials are surprisingly similar. When slowly pushed, they deform via intermittent slips, similar to earthquakes. The statistics of these slips agree across vastly different structures and scales. A simple analytical model explains why this is the case. The model also predicts which statistical quantities are independent of the microscopic details (i.e., they are “universal”), and which ones are not. The model provides physical intuition for the deformation mechanism and new ways to organize experimental data. It also shows how to transfer results from one scale to another. The model predictions agree with experiments. The results are expected to be relevant for failure prediction, hazard prevention, and the design of next-generation materials.
Changes in Obesity Phenotype Distribution in Mixed-ancestry South Africans in Cape Town Between 2008/09 and 2014/16

Background: The concept of obesity phenotypes encompasses a different approach to evaluating the relationship between obesity and cardiometabolic diseases. Considering the minimal research on obesity phenotypes in Africa, we investigated these changes from 2008/09 to 2014/16 in the mixed ancestry population in Cape Town, South Africa. Methods: In all, 928 (2008/09) and 1969 (2014/16) ≥20 year old participants were included in two community-based cross-sectional studies. For obesity phenotype classification, a combination of body mass index (BMI) categories and prevalent cardiometabolic disease risk factors were used, with the presence of ≥2 cardiometabolic abnormalities defining abnormal metabolic status. Interaction tests were used to investigate changes in their distribution across the years of study. Results: Distribution of BMI categories differed significantly between the 2 years; normal weight, overweight and obese: 27.4, 27.4, and 45.3% in 2008/09 vs. 34.2, 23.6, and 42.2% in 2014/16 (p = 0.001). There was no differential effect in the distribution of obesity phenotypes pattern across the two time-points (interaction p = 0.126). Across BMI categories, levels of cardiometabolic risk factors linearly deteriorated in both metabolically healthy and abnormal participants (all p ≤ 0.018 for linear trends). Findings were not sensitive to the number of metabolic abnormalities included in the definition of obesity phenotypes. Conclusions: Our study showed negligible differences in obesity phenotypes over time, but a high burden of metabolic abnormalities among normal weight participants, and a significant proportion of metabolically health obese individuals. Further investigation is needed to improve risk stratification and cost-effective identification of individuals at high risk for cardiometabolic diseases.
Gaussian-spherical restricted Boltzmann machines

We consider a special type of restricted Boltzmann machine (RBM), namely a Gaussian-spherical RBM where the visible units have Gaussian priors while the vector of hidden variables is constrained to stay on an L 2 sphere. The spherical constraint having the advantage to admit exact asymptotic treatments, various scaling regimes are explicitly identified based solely on the spectral properties of the coupling matrix (also called weight matrix of the RBM). Incidentally these happen to be formally related to similar scaling behaviors obtained in a different context dealing with spatial condensation of zero range processes. More specifically, when the spectrum of the coupling matrix is doubly degenerated an exact treatment can be proposed to deal with finite size effects. Interestingly the known parallel between the ferromagnetic transition of the spherical model and the Bose–Einstein condensation can be made explicit in that case. More importantly this gives us the ability to extract all needed response functions with arbitrary precision for the training algorithm of the RBM. This allows us then to numerically integrate the dynamics of the spectrum of the weight matrix during learning in a precise way. This dynamics reveals in particular a sequential emergence of modes from the Marchenko–Pastur bulk of singular vectors of the coupling matrix.
Understanding Infection-Induced Thrombosis: Lessons Learned From Animal Models

Thrombosis is a common consequence of infection that is associated with poor patient outcome. Nevertheless, the mechanisms by which infection-associated thrombosis is induced, maintained and resolved are poorly understood, as is the contribution thrombosis makes to host control of infection and pathogen spread. The key difference between infection-associated thrombosis and thrombosis in other circumstances is a stronger inflammation-mediated component caused by the presence of the pathogen and its products. This inflammation triggers the activation of platelets, which may accompany damage to the endothelium, resulting in fibrin deposition and thrombus formation. This process is often referred to as thrombo-inflammation. Strikingly, despite its clinical importance and despite thrombi being induced to many different pathogens, it is still unclear whether the mechanisms underlying this process are conserved and how we can best understand this process. This review summarizes thrombosis in a variety of models, including single antigen models such as LPS, and infection models using viruses and bacteria. We provide a specific focus on Salmonella Typhimurium infection as a useful model to address all stages of thrombosis during infection. We highlight how this model has helped us identify how thrombosis can appear in different organs at different times and thrombi be detected for weeks after infection in one site, yet largely be resolved within 24 h in another. Furthermore, we discuss the observation that thrombi induced to Salmonella Typhimurium are largely devoid of bacteria. Finally, we discuss the value of different therapeutic approaches to target thrombosis, the potential importance of timing in their administration and the necessity to maintain normal hemostasis after treatment. Improvements in our understanding of these processes can be used to better target infection-mediated mechanisms of thrombosis.
Per- and Polyfluoroalkyl Substances (PFAS): Significance and Considerations within the Regulatory Framework of the USA

Per- and polyfluoroalkyl substances (PFAS) are an emerging environmental crisis. Deemed forever chemicals, many congeners bioaccumulate and are incredibly persistent in the environment due to the presence of the strong carbon-fluorine covalent bonds. Notable PFAS compounds include perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and GenX. Robust toxicological knowledge exists for these substances, but regulatory decisions based on this knowledge has fallen behind. The United States Environmental Protection Agency (EPA) has addressed this issue with the PFAS Action Plan and EPA Council on PFAS, but the regulatory framework is severely lacking. Currently, no federal regulations or standards exist. Many occupational and non-occupational human cohorts exist that can lend knowledge on the environmental implications of PFAS and associated health effects. Occupationally, firefighters face significant exposure risks due to use of PFAS containing aqueous film-forming foams (AFFFs) and personal protective equipment contamination. Non-occupationally, wastewater discharge in North Carolina led to chronic and widespread residential exposure to GenX via drinking water contamination. This public health review seeks to convey the current and future significance of PFAS as an environmental contaminate, to lend considerations on regulatory frameworks within the USA, and to help guide and promote the need for future epidemiological studies in order to tackle this environmental emergency. While the PFAS Action Plan creates a scientific and regulatory foundation, it is important to take these lessons and apply them to future environmental health issues.
Livelihoods and Food Security Among Rural Households in the North-Western Mount Kenya Region

Food insecurity remains a major concern for numerous rural households in Sub-Saharan Africa who rely on agriculture as their main source of livelihood. The assessment of the links between food security and livelihoods is central for overcoming widespread food insecurity. However, assessments remain challenging due to food security’s multi-dimensionality and the challenge of finding indicators that are comparable and applicable to various contexts. This study addresses this challenge by adapting a food security index (FSI) and uses it to assess the livelihood drivers of food security. The index captures the multi-dimensionality of food security using conventional food security indicators. The assessed indicators include measures of “food consumption score”, “household dietary diversity score”, “coping strategies index”, the “household food insecurity access scale” and “months of adequate household food provisioning”. The study covered 600 randomly selected households representative of three agro-ecological zones located close to large-scale agricultural investment in Mount Kenya region in Kenya. We used linear regression to identify livelihood factors significantly influencing food security. Spearman’s rank-order correlation and student’s T-test demonstrated a strong and significant correlation between the composite FSI index and each classical indicators of food security. Overall, 32% of the households were food secure and 68% were food insecure. Households’ ownership of productive hand tools, followed by off-farm income, consumption of own produced food, type of agro-ecological zone, farm income and number of main crops infested by pests had a significant effect on household food security. All these factors, except the number of main crops infested by pests, positively influenced household food security. Households in humid agro-ecological zone were less food secure than households in semi-humid and semi-arid zones. Household size, the size of accessible land and households’ members’ participation to large agricultural investments (as wage workers or sub-contract farmer) were not significantly influencing food security. Households of the Mount Kenya region need alternative off-farm income sources combined with further support to improve sustainable agriculture management with appropriate hand tools for increased production, and improve value chains to increase farm income.
Humans Optimize Ground Contact Time and Leg Stiffness to Minimize the Metabolic Cost of Running

Trained endurance runners appear to fine-tune running mechanics to minimize metabolic cost. Referred to as self-optimization, the support for this concept has primarily been collated from only a few gait (e.g., stride frequency, length) and physiological (e.g., oxygen consumption, heart rate) characteristics. To extend our understanding, the aim of this study was to examine the effect of manipulating ground contact time on the metabolic cost of running in trained endurance runners. Additionally, the relationships between metabolic cost, and leg stiffness and perceived effort were examined. Ten participants completed 5 × 6-min treadmill running conditions. Self-selected ground contact time and step frequency were determined during habitual running, which was followed by ground contact times being increased or decreased in four subsequent conditions whilst maintaining step frequency (2.67 ± 0.15 Hz). The same self-selected running velocity was used across all conditions for each participant (12.7 ± 1.6 km · h−1). Oxygen consumption was used to compute the metabolic cost of running and ratings of perceived exertion (RPE) were recorded for each run. Ground contact time and step frequency were used to estimate leg stiffness. Identifiable minimums and a curvilinear relationship between ground contact time and metabolic cost was found for all runners (r2 = 0.84). A similar relationship was observed between leg stiffness and metabolic cost (r2 = 0.83). Most (90%) runners self-selected a ground contact time and leg stiffness that produced metabolic costs within 5% of their mathematical optimal. The majority (n = 6) of self-selected ground contact times were shorter than mathematical optimals, whilst the majority (n = 7) of self-selected leg stiffness' were higher than mathematical optimals. Metabolic cost and RPE were moderately associated (rs = 0.358 p = 0.011), but controlling for condition (habitual/manipulated) weakened this relationship (rs = 0.302, p = 0.035). Both ground contact time and leg stiffness appear to be self-optimized characteristics, as trained runners were operating at or close to their mathematical optimal. The majority of runners favored a self-selected gait that may rely on elastic energy storage and release due to shorter ground contact times and higher leg stiffness's than optimal. Using RPE as a surrogate measure of metabolic cost during manipulated running gait is not recommended.
Revenue Statistics in Africa 2018

The LAC average refers to the Revenue Statistics in Latin America and the Caribbean 2018 publication. oe.cd/revenue-statistics-in-latin-america-and-the-caribbean The Republic of the Congo's1 tax-to-GDP ratio in 2016 (16.0%) was lower than the average of the 21 African countries in Revenue Statistics in Africa (18.2%) by 2.2 percentage points and also lower than the LAC average (22.7%). The tax-to-GDP ratio in the Republic of the Congo1 decreased by 0.6 percentage points, from 16.6% in 2015 to 16.0% in 2016. In comparison, the average for the 21 African countries in Revenue Statistics in Africa 2018 remained at 18.2% over the same period. The tax-to-GDP ratio in the Republic of the Congo has increased since 2000, when it was 4.3%. Over the same period, the average for the 21 African countries increased from 13.1% in 2000 to 18.2% in 2016. Across this period, the highest tax-to-GDP ratio in the Republic of the Congo was 16.6% in 2015, with the lowest being 4.3% in 2000.
An Integer Non-Cooperative Game Approach for the Transactive Control of Thermal Appliances in Energy Communities

Non-cooperative scheduling games can be used to coordinate residential loads in order to achieve a common goal while accounting for individual consumer’s interests, privacy, and autonomy. However, a significant portion of the residential flexibility—Thermostatically Controlled Loads (TCLs) such as water and space heating/cooling appliances—has not been fully addressed under this game theoretic approach: their comfort constraints and integer control were not considered. This paper presents a method for properly including TCLs in this framework and discusses its application in energy communities. Specifically, we propose a general mathematical formulation for considering users’ comfort in non-cooperative games. We model the integer nature of the TCLs control with binary variables and show that optimal or close to optimal (less than 1%) solutions are reached. Moreover, different total cost functions can be used depending on the market context and the objective of the demand management program. To illustrate and discuss these aspects in practical applications, we used a case study of an energy community in Spain. The results show that the TC solutions are optimal or only 0.80% worse than optimal; different total cost functions result in different results (load curve smoothing or peak load reduction); consumers’ comfort is respected; and the proposed game model cooperates with consumers in order to minimize community’s costs.
Cocaine Mediates the C Early Career Investigator Commentary BP ellular Mechanism of Satiation

Addiction can be characterized as compulsive drug use despite severe negative consequences and psychostimulant abuse having a detrimental societal and economic impact (1). A defining feature of addiction is the transition from occasional drug use to a compulsive need to seek and consume drugs. Glutamatergic input to the nucleus accumbens (NAc) is an important neural circuit pathway in addiction, and exposure to environmental cues previously associated with drug use can initiate craving and drug-seeking behaviors by activating glutamatergic projections from the prefrontal cortex to the NAc (2). Specifically, the prelimbic region of the medial prefrontal cortex, which sends significant projections to the core of the NAc, is associated with initiation of drug seeking (3), whereas the ventral infralimbic projects primarily to the shell of the NAc and is implicated in the inhibition of drug seeking (4). Studying the prelimbic to NAc core neural circuit is relevant in the context of drug reinstatement because the prelimbic region regulates goal-directed behavior and actionoutcome contingencies, key features of cue-induced reinstatement models. In this issue of Biological Psychiatry, Spencer et al. (5) explored the molecular and cellular events that occur during the transition from a highly motivated state of drug seeking to the temporary state of satiation that follows the consumption of cocaine. The authors devised a novel model of cocaine reinstatement that allowed for the study of transient synaptic plasticity (t-SP) during specific phases of relapse: 1) nonreinforced drug seeking, 2) drug use, and 3) a return to the nonreinforced drug-seeking state. Previously, the authors demonstrated that cocaine-associated cues induced drugseeking behaviors along with a rapid transient increase in dendritic spine head diameter (dh) and increased synaptic potentiation in the NAc core (6). Interestingly, the increased synaptic potentiation was positively correlated with cocaine seeking that required prefrontal cortex activity (6). It should be noted that the enhanced potentiation following cocaine withdrawal is in contrast to findings that cocaine reduces the ability of prefrontal inputs to induce long-term potentiation and long-term depression (7). One interesting possibility raised by these studies is that cocaine reduces the ability of stimuli unassociated with drug use to induce synaptic plasticity, whereas cue-associated stimuli readily induce plasticity. Thus, exposure to cocaine permits environmental cues to elicit rapid t-SP. Moreover, increased synaptic potentiation after cocaine use may reflect the uncontrollable desire to seek and consume cocaine, which is not evident in the case of natural rewards such as sucrose (8). What is not understood are the events that occur during the transition from a highly motivated state of drug seeking to drug use, which results in temporary satiation reflected by the decrease in motivation to seek
Psychiatric Emergency in Children and Adolescents: A Retrospective Study in Parma Local Health Unit

The mental health care system in Italy is based on Law 180/70 which leaves great regional autonomy about the management of adolescent patients suffering from psychiatric diseases. The aim of this study is the evaluation of demographic, social, and clinical features of minors admitted to psychiatric wards, as starting point to improve individualized services for them. Data about all under 18s consecutively admitted to Parma's psychiatric wards from 2013 to 2015 were retrospectively collected from medical records. Diagnoses were classified according to ICD-10 criteria, and statistical analysis was performed using SPSS statistical software (IBM SPSS Statistics 22.0) for Windows. Clinical samples include 51 cases, 30 males (mean age: 15.5 years, ranging from 12 to 17 years) and 21 females (mean age: 15.9, ranging from 14 to 17 years). The most frequent diagnosis is conduct disorder (39.2%), with higher prevalence among males. Following this, 23.5% of the patients present comorbidity issues and 9.8% suffer from personality disorders, which is more frequent among females. High percentages of foreigners (31.4%), adopted minors (15.7%), and drug users (40%) are reported. Furthermore, data reveal that unprotective family environment, registered in 80.4% of cases, plays an important role as risk factor for the development of mental disease, readmissions in psychiatric wards, and discharge to residential facilities. Readmissions, as well as compulsory treatments (11 cases), are mainly required in case of conduct disorders and comorbidity diagnosis. Lastly, in contrast with the situation before hospital admission, most patients (63.3%) are discharged and sent to community residential facilities. Findings can be useful to improve the management of psychiatric emergencies in minors, focusing on their specific needs, such as conduct disorders and substance abuse, and to face emerging challenges, for example, mental health disease associated with the growing phenomenon of immigration.