Miracle-dz/UniFAR-FTUs huggingface dataset:
Medullary Thyroid Cancer with Ectopic Cushing's Syndrome: A Case Report and Systematic Review of Detailed Cases from the Literature.

Background: Medullary thyroid cancer (MTC) is a neuroendocrine tumor arising from parafollicular C-cells of the thyroid gland that, in rare cases, can cause a paraneoplastic ectopic Cushing's syndrome (ECS). The development of Cushing's syndrome (CS) in MTC patients is generally associated with advanced disease and poor prognosis. Summary: We described a case of severe CS due to MTC in a young male. We performed a systematic review to identify cases of ECS due to MTC. We searched PubMed, Scopus, and Web of Science for publications between database inception and February 2022 and we collected the patient characteristics, disease presentation, employed treatment strategies, and disease outcomes. In addition to our patient, we identified 96 cases of ECS due to MTC reported in literature. Mean age at diagnosis was 44.4 years (range 10-84), and there was a male predominance (male:female [M:F] = 1.8:1). Most patients (51%) presented with metastatic disease at diagnosis and showed severe hypercortisolism. Seventeen patients developed distant metastasis and hypercortisolism during follow-up. Interestingly, in 48% of patients, the diagnosis of CS followed the diagnosis of MTC with a median time of 48 months but, among patients in whom the diagnosis was concomitant (38%), symptoms due to hypercortisolism were frequently the reason for seeking medical advice. Pathology results showed evidence of adrenocorticotropic hormone (ACTH) or corticotropin releasing hormone (CRH) positive cells in 76% of patients in whom they were tested. The management of hypercortisolism was challenging in most patients with 48% requiring, eventually, definitive treatment with bilateral adrenalectomy (BLA). Recently, some limited evidence has emerged regarding tyrosine kinase inhibitors (TKIs) treatment for hypercortisolism in patients with ECS due to MTC. Despite limited information on survival, prognosis was generally poor and the main causes of death were either complications of CS or disease progression. Conclusions: Despite its rarity, MTC should be considered in the differential diagnosis of ECS. Management of hypercortisolism is a key factor to improve the patient's symptoms but it is often challenging and BLA is frequently required. Further studies are needed for investigating the role of TKIs in patients with MTC with ECS.
BrainGAN: Brain MRI Image Generation and Classification Framework Using GAN Architectures and CNN Models

Deep learning models have been used in several domains, however, adjusting is still required to be applied in sensitive areas such as medical imaging. As the use of technology in the medical domain is needed because of the time limit, the level of accuracy assures trustworthiness. Because of privacy concerns, machine learning applications in the medical field are unable to use medical data. For example, the lack of brain MRI images makes it difficult to classify brain tumors using image-based classification. The solution to this challenge was achieved through the application of Generative Adversarial Network (GAN)-based augmentation techniques. Deep Convolutional GAN (DCGAN) and Vanilla GAN are two examples of GAN architectures used for image generation. In this paper, a framework, denoted as BrainGAN, for generating and classifying brain MRI images using GAN architectures and deep learning models was proposed. Consequently, this study proposed an automatic way to check that generated images are satisfactory. It uses three models: CNN, MobileNetV2, and ResNet152V2. Training the deep transfer models with images made by Vanilla GAN and DCGAN, and then evaluating their performance on a test set composed of real brain MRI images. From the results of the experiment, it was found that the ResNet152V2 model outperformed the other two models. The ResNet152V2 achieved 99.09% accuracy, 99.12% precision, 99.08% recall, 99.51% area under the curve (AUC), and 0.196 loss based on the brain MRI images generated by DCGAN architecture.
COMPARATIVE STUDY OF HERBAL BIOENHANCER CONTAINING NANO FORMULATION FOR ORAL DELIVERY OF PACLITAXEL: PHARMACOKINETIC AND CYTOTOXICITY ANALYSIS

Objective: The main objective of this study was to develop novel formulation containing herbal bioenhancer to increase the bioavailability of poorly water-soluble anticancer drug. Material and methods: Paclitaxel (PTX) loaded bioenhancer nanoparticle prepared by Emulsification solvent evaporation method by using Eudragit RLPO as a polymer and to evaluate its in-vivo pharmacokinetics (PK) and cytotoxicity studies The result is reduced oral bioavailability, which limits the use of paclitaxel, a crucial anticancer medication, when taken orally. Though multiple formulation approaches have been taken to fight this low absorption profile but consequence of different herbal bioenhancer, happening CYP3A and P-gp inhibitor on augmentation of paclitaxel plasma. Result: The prepared nanoparticles were evaluated for in vitro cell cytotoxicity study by MTT assay on lung cancer cell line and pharmacokinetic profile. The result revealed good in vitro properties with bioenhancer. Conclusion: The goal of the present work is to asses any modification in oral pharmacokinetics of paclitaxel. Therefore, it can be concluded that addition of bioenhancer with antitumor drug can enhance its prolifertive effect. However, further in vivo studies are recommended to establish the fact.
CNN Based Ensemble Approach for Malfunction Detection from Machine Sounds

Together with the meaning and essence of data for the company nowadays; The variety of data also differs. One of these differentiating data types is sound. Borusan Makina ve Güç Sistemleri A. Ş. the data obtained from the Caterpillar construction machines of. The machine sound gives clues about many malfunctions. Artificial intelligence systems of the heard sound will be integrated into business processes. Every tone can be converted. With this, the properties and estimates of the sound grids are used. In this direction; While the incident is getting in the way of his business, an unfortunate project occurs with a similar visitor. The traditional will use a meaningful method by listening to the producer's sound and technology and innovation to develop easy blueprints of decisions that cannot be diverted to sound data. Thanks to the real-time model with short-term audio recording, it is instantly predicted whether there is a problem in the machine. Free from personal and technical comments; By examining the patterns of sound waves, it is aimed to be made without cancellation.
FABRICATION OF MEBENDAZOLE LOADED SOLID LIPID NANOPARTICLES: FORMULATION, OPTIMIZATION, CHARACTERIZATION, STABILIZATION, AND IN-VITRO EVALUATION

The research focused on the formulation, optimization, characterization stabilization and in vitro evaluation of Mebendazole loaded solid lipid nanoparticles (MEB-SLN) using response surface methodology. MEB-SLN was developed using the melt-emulsification ultrasonication method. The optimized formulation contains Compritol 888 ATO as a solid lipid and Poloxamer 407 as a surfactant. The optimized MEB-SLN was spherical, and had an average size of 230.4nm, and zeta potential of -21.9mV. The physiochemical characterization included the evaluation of surface morphology, drug entrapment, x-ray diffraction studies, and differential scanning calorimetry. In vitro drug release studies revealed that MEB-SLN would release drugs for up to 24 hrs. The formulation was found to be significantly quite stable in the refrigerator than at room temperature, as per stability tests. As a result of these findings, MEB-SLN was identified as a possible drug carrier. This provides a framework for further exploration of the developed formulation.
Enhanced Thrombin Generation Is Associated with Worse Left Ventricular Scarring after ST-Segment Elevation Myocardial Infarction: A Cohort Study

Acute myocardial infarction (AMI) is associated with heightened thrombin generation. There are limited data relating to thrombin generation and left ventricular (LV) scarring and LV dilatation in post-MI LV remodeling. We studied 113 patients with ST-segment elevation myocardial infarction (STEMI) who had undergone primary percutaneous coronary intervention (PPCI) (n = 76) or pharmaco-invasive management (thrombolysis followed by early PCI, n = 37). Endogenous thrombin potential (ETP) was measured at baseline, 1 month and 6 months. Cardiovascular magnetic resonance imaging was performed at baseline and 6 months post-MI. Outcomes studied were an increase in scar change, which was defined as an increase in left ventricular infarct size of any magnitude detected by late gadolinium enhancement, adverse LV remodeling, defined as dilatation (increase) of left ventricular end-diastolic volume (LVEDV) by more than 20% and an increase in left ventricular ejection fraction (LVEF). The mean age was 55.19 ± 8.25 years and 91.2% were men. The baseline ETP was similar in the PPCI and pharmaco-invasive groups (1400.3 nM.min vs. 1334.1 nM.min, p = 0.473). Each 10-unit increase in baseline ETP was associated with a larger scar size (adjusted OR 1.020, 95% CI 1.002–1.037, p = 0.027). Baseline ETP was not associated with adverse LV remodeling or an increase in LVEF. There was no difference in scar size or adverse LV remodeling among patients undergoing PPCI vs. pharmaco-invasive management or patients receiving ticagrelor vs. clopidogrel. Enhanced thrombin generation after STEMI is associated with a subsequent increase in myocardial scarring but not LV dilatation or an increase in LVEF at 6 months post-MI.
Not just by rates of recidivism: how NYC black men define success after prison

Abstract A qualitative study using data from semi-structured interviews of 17 formerly incarcerated African American men was used to provide an understanding of post-prison success defined by the men after having been in the community at least 3 years. Rejecting traditional notions of success related to rates of recidivism as the defining element of success, success, as defined by the men in the study included several components. The findings of this study demonstrate that success is a construct inclusive of material, social, and psychological components. Various themes emerged from the data to which respondents attached importance that were linked to each component of success. These findings can enhance the practice for a range of human service providers and others who work with justice-involved African American men and enable them to better understand and serve this population, while also encouraging the development of additional methods to address the challenges related to release post-prison, reentry policy, and reentry programing.
Seasonal Variations in the Assembly of Dung Beetles (Coleoptera: Geotrupidae and Scarabaeidae) Attracted to Macaque Feces in Temperate Forests in Japan

Abstract Dung beetles attracted to the feces of wild Japanese macaques (Primates: Macaca fuscata Blyth) were studied at two temperate sites in Japan, Kinkazan (dominated by deciduous forest) and Yakushima (dominated by evergreen forest), to determine if temporal variations occur in the dung beetle community. Data from 428 pitfall traps baited with fresh Japanese macaque feces and placed during 15 sampling periods from 2015 to 2019 were analyzed. We captured 1,682 beetles (two families, five genera, and nine species) from Kinkazan and 1,102 beetles (two families, four genera, and nine species) from Yakushima. More than 50% of the beetles captured were small (body size < 10 mm) tunnelers (species of Onthophagus Latreille and Caccobius Thomson). Large (body size > 10 mm) tunnelers (species of Phelotrupes Jekel and Copris acutidens Motschulsky) were common in Kinkazan, and dwellers (species of Aphodius Illiger) were frequently obtained in Yakushima. At both sites, the capture rate and number of trapped beetles were greater during the summer and autumn (Kinkazan: 90–100%; Yakushima: 64–95%) than during other seasons. For several species, the number of beetles collected in each trap was positively correlated with mean temperature, but no relationship with rainfall was observed. From an ecological viewpoint, dung beetles burying seeds embedded in macaque feces might affect plant fitness in the initial stages.
Follow-up evaluation of the Fibra Study: sociodemographic, cognitive, and frailty characterization of older adults in Campinas and Ermelino Matarazzo, SP

Abstract Objective To investigate and compare the sociodemographic, cognitive and frailty profile of participants from the Frailty in Brazilian Older Adults (Fibra) study regarding follow-up (FW) and baseline (BL) measurements carried out in 2016-2017 and 2008-2009, respectively. Methods A total of 1,284 older adults living in Campinas and Ermelino Matarazzo (SP), Brazil, participated in the BL, comprising a pooled sample. At FW, 549 older adults (42.7%) were interviewed again; 192 had died (14.9%) and 543 were lost to follow-up (42.4%). Sex, age, education, marital status, family income, housing arrangement, cognitive status (Mini-Mental State Examination) and frailty phenotype (score ≥3 out of 5) were evaluated at both timepoints. Intergroup and intragroup differences were verified by Pearson's chi-square and McNemar's tests. Statistical significant level was set at p<0.05 Results The survivors were younger (72.2±5.3 years) than the deceased (75.5±6.8 years) and individuals included in the FW were mostly married, higher educated, cognitively unimpaired and pre-frail. Between BL and FW there was an increase in the number of participants who lived alone (17.1% vs. 22.0%), had no partner (46.4% vs. 55.4%), a family income <3 minimum wages (52.2% vs. 62.2%), cognitive impairment (17.7% vs. 23.5%) and frailty (9.8% vs. 24.5%). Conclusion Between BL and FW there was an increase in the physical, cognitive and social vulnerability of the older adults. These results reinforce the importance of public policies that favor the quality of life of older people and a reduction in health inequities throughout life.
21st Century Teaching Skills and Teaching Standards Competence Level of Teacher

Teachers’ roles have changed dramatically over the last decades – from traditional spoon-feeders to facilitators of learning. Teacher education institutions play a huge role in getting them ready for the field. Thus, this study probed the 21st century teaching skills and teaching standards competence level of the CTE graduates of Mindoro State College of Agriculture and Technology (MinSCAT) who graduated in the years 2016, 2017 and 2018. Two hundred and fifteen (215) participating teachers (MinSCAT Graduates) and their immediate supervisors answered a two-part questionnaire through Google Forms exploring the extent of the graduates’ skills and competence. The data collected were sorted and subjected to t-Test, ANOVA and multiple linear regression. The results showed that the teachers’ skills and competence are of high to very high extent. Specifically, the graduates received high ratings on their effective communication skills, life and career skills, and personal growth and professional development. The teachers showed remarkable performances in the light of these indicators. One way ANOVA revealed that there are significant differences in the level of the graduates’ 21st century teaching skills and teaching standards competence level in terms of their indicators. The study recommends for the CTE faculty and students to hold frequent dialogues and consultations to ensure the development of potential and acquisition of 21st century teaching skills and teaching standard competence of the CTE students and to address students’ challenges. Consistent sensitivity to the needs of the faculty and the students should be given preferential attention to develop the culture of excellence in the department.
Pemanfaatan Teknologi Informasi Berbasis E-Commerce Terhadap Peningkatan Kualitas dan Kinerja SDM Untuk Meningkatkan Profit UKM di Masa Pandemi

Pengabdian ini berjudul penerapan ilmu manajemen dalam Pemanfaatan Teknologi Informasi Berbasis E-commerce Terhadap Peningkatan Kualitas Dan Kinerja Sumber Daya Manusia Untuk Meningkatkan Profit UMKM Di Masa Pandemi. Tujuan umum dari kegiatan pengabdian kepada masyarakat ini adalah Memberikan pengetahuan dan tools Pemanfaatan Teknologi Informasi Berbasis E-commerce Terhadap Peningkatan Kualitas Dan Kinerja Sumber Daya Manusia Untuk Meningkatkan Profit UMKM Di Masa Pandemi. Metode yang digunakan adalah metode survey dan penyampaian materi secara langsung serta simulasi dan diskusi mengenai manajemen, pengelolaan keuangan, pemasaran produk dan penerapan MSDM dalam pengembangan UKM Jabar Juara kota Depok. Kesimpulan dari pengabdian kepada masyakat ini adalah bahwa akan dilakukan pendampingan dalam manajemen dalam pengembangan Sumber Daya Manusia dengan cara memberikan wawasan terkait urgensi penggunaan E-commerce untuk meningkatkan penjualan di masa Pandemi
The effect of woody endocarpium of walnut alcoholic extract on acetic acid-induced ulcerative colitis in rats

Various pharmacological effects including anti-inflammatory and anti-oxidant properties were shown for woody endocarpium of walnut alcoholic extract (WEW). In the study, the effect of the WEW extract in acetic acid induced ulcerative colitis in rats was evaluated. Thiol, glutathione peroxidase (GPX), malondialdehyde (MDA), superoxide dismutase (SOD) and gastric acid levels and pathological changes in the colon were investigated in the control group (C), ulcerative colitis group (UC), UC groups treated with WEW extract (10, 20, and 50 mg/kg) and sulfasalazine. Levels of gastric acid, MDA and pathological scores in colon were increased but SOD, GPX and thiol levels were decreased in UC animals compared to those of the control group (p<0.001). Treatment with the highest concentration of extract significantly improved level of thiol and pathological scores compared to the UC group (p<0.05 to p<0.001). Treatment with the two higher concentrations of extract also significantly decreased acid level compared to the UC group (p<0.01 to p<0.001). There was significant improvement in MDA due to treatment with the all concentrations of the extract (p<0.001). Sulfasalazine treatment also significantly improved most parameters compared to the UC group but did not changed pathological scores (p<0.05 to p<0.001). These results indicated a possible preventive therapeutic effect for the WEW extract on UC.
High precision, low disturbance calibration of the High Voltage system of the CMS Barrel Electromagnetic Calorimeter

The CMS Electromagnetic Calorimeter is made of scintillating lead tungstate crystals, using avalanche photodiodes (APD) as photo-detectors in the barrel part. The high voltage system, consisting of 1224 channels, biases groups of 50 APD pairs, each at a voltage of about 380 V. The APD gain dependence on the voltage is 3pct/V. A stability of better than 60 mV is needed to have negligible impact on the calorimeter energy resolution. Until 2015 manual calibrations were performed yearly. A new calibration system was deployed recently, which satisfies the requirement of low disturbance and high precision. The system is discussed in detail and first operational experience is presented. Presented at NDIP17 8th International Conference on New Developments In Photodetection High precision, low disturbance calibration of the High Voltage system of the CMS Barrel Electromagnetic Calorimeter Badder Marzocchia,∗, on behalf of the CMS Collaboration aUniversità La Sapienza and INFN, Rome, Italy
Cloud Computing and Networking for SmartFarm AgriTech

In this paper, the implementation of SmartFarm AgriTech is done using IoT and cloud computing. The current world population is 7.9 billion and supposed to reach 12 billion by 2050, and it is difficult to feed such population in the future. So, for feeding the entire population, the agriculture sector should be embedded with the latest technologies. People living in urban city will be covered with their work and day to day activities which makes it really difficult to travel the village and monitor their cultivation regularly. Without proper maintenance of farms, it is hard to get the desired results, so using the cloud computing, IOT, networking, and many other technologies, one can easily maintain and monitor the crops, weather, water, and spraying fertilizers whenever needed. This SmartFarm AgriTech System is designed using Raspberry Pi and Arduino as the main microcontrollers to control the various sensors, relay-switch, and motor. AWS and ThingSpeak are used to create server and APIs to collect and store the data through Internet or via a Local Area Network (LAN). In addition to that, a GUI (Graphical User Interface) application is also created to control and monitor the data coming from Raspberry Pi and Arduino board.
Synthesis, characterization, anti-inflammatory and anti-oxidant activities of novel 2, 4-di substituted 1, 5- benzodiazepine derivatives

The study's goal is to synthesis novel benzodiazepine analogues, some of which are chalcones. The elemental analysis, infrared, and 1H nuclear magnetic resonance examinations examined the structures of the newly produced substances. To test for anti-inflammatory and anti-oxidant properties, all substances bearing a descriptor were evaluated. Here, 1,5-(disubstituted phenyl)-2,4-pentadien-1-one derivatives are created from scratch using a new process. By condensing cinnamaldehyde with different aromatic ketones in the presence of 10% NaOH as a base, 1,5-(disubstituted phenyl)-2,4-pentadien-1-one was produced. 2-(substituted phenyl)-3-styryl-2,3-dihydro-1H-benzodiazepine derivatives were synthesised from 1,5-(disubstituted phenyl)-2,4-pentadien-1-one on cyclization with o-phenylene diamine in the presence of NaOH as base. Carrageenan and formalin-induced rat paw edoema technique was used to evaluate the antioxidant and anti-inflammatory activities of the final synthesised benzodiazepine derivatives. Compared to the usual ascorbic acid and diclofenac sodium, the compounds displayed significant anti-inflammatory effect. This means that nitro, chloro, fluoro, and bromo included electron withdrawing groups, which caused an increase in anti-inflammatory action. Most of the produced drugs had strong anti-inflammatory efficacy.
Molecular Interaction Analysis of Homodihydrocapsaicin as COX-2 Inhibitor

Pemanfaatan Capsicum frutescens L sebagai terapi berbagai penyakit salah satunya inflamasi di dalam tubuh, menjadi fokus saat ini dikarenakan mengandung senyawa bersifat farmakologis seperti homodihydrocapsaicin. Senyawa yang diperoleh homodihydrocapsaicin didownload SMILES dari aplikasi PubChem dengan (CID: 3084336) diunduh dari database PubChem, Protein COX-2 (ID 6cox) diunduh dari Protein Data Bank. Proses preparasi protein dan ligan, docking, visualisasi maupun analisis mengadopsi penelitian sebelumnya. Tujuan penelitian menganalisis interaksi molekuler senyawa homodihydrocapsaicin sebagai Inhibitor COX-2. Interaksi senyawa homodihydrocapsaicin dan COX-2 membentuk beberapa ikatan residu asam amino yang membentuk ikatan hidrofobik, ikatan hydrogen, dan gaya van der Waals. Energi ikatan yang terbentuk adalah -284.86 cal/mol, sehingga senyawa homodihydrocapsaicin sebagai terapi inflamasi dengan menghambat mediator inflamasi (COX-2). Capsicum frutescens L. dapat dimanfaatkan sebagai terapi inflamasi didalam tubuh.
Spontaneous Coronary Artery Dissection Presenting As ST-Segment Elevation Myocardial Infarction

Spontaneous coronary artery dissection (SCAD) is a non-traumatic spontaneous separation of a coronary wall that can present as acute myocardial infarction. Pregnant females are already at a considerably higher risk of acute myocardial infarction when compared to non-pregnant women of child-bearing age, and dissection explains the majority of these cases. Here, we present a 36-year-old female at 36-weeks gestation who experienced ventricular fibrillation arrest after ST-segment elevation myocardial infarction (STEMI) secondary to spontaneous dissection of the left anterior descending (LAD) coronary artery.