Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychometric Evaluation of the Polish adaptation of a Self-Report Form of the DSM-5 Level of Personality Functioning Scale (LPFS-SR).

OBJECTIVES This study examined psychometric properties of the Polish adaptation of a Self-Report Form of the DSM-5 Level of Personality Functioning Scale (LPFS-SR). It is a scale designed to measure general impairment, jointly with a detailed assessment of distinguished components of personality functioning characterized in terms of disturbances in self (identity and self-direction) and interpersonal (empathy and intimacy) functioning - Criterion A in the DSM-5 Alternative Model for Personality Disorders (AMPD). METHODS The study involved a non-clinical sample of N = 242 adults (52.9% female; Mage = 30.63 years; SDage = 11.81 years). To provide an evaluation of the criterion validity, Personality Inventory for DSM-5 (PID-5), Personality Inventory for ICD-11 (PiCD), Level of Personality Functioning Scale - Brief Form 2.0 (LPFS-BF 2.0), and Big Five Inventory-2 (BFI-2) were administered. RESULTS Our data supported that identity, self-direction, intimacy, and empathy components of the LPFS-SR can be characterized by a single, global dimension of personality dysfunction, consistent with the assumption that DSM-5 Criterion A is a relatively homogeneous construct. The LPFS-SR showed good reliability estimates and demonstrated conceptually sound associations with the PD severity index and related measures of personality functioning. Moreover, all the LPFS-SR components manifested at least partial distinction from maladaptive personality traits (i.e., Criterion B in the DSM-5 AMPD). CONCLUSIONS These findings provide support for the validity of the Polish adaptation of the LPFS-SR as an operationalization of impairment in the core and common features of personality pathology described in the DSM-5 alternative model.
CRISPR Approaches for the Diagnosis of Human Diseases

CRISPR/Cas is a prokaryotic self-defense system, widely known for its use as a gene-editing tool. Because of their high specificity to detect DNA and RNA sequences, different CRISPR systems have been adapted for nucleic acid detection. CRISPR detection technologies differ highly among them, since they are based on four of the six major subtypes of CRISPR systems. In just 5 years, the CRISPR diagnostic field has rapidly expanded, growing from a set of specific molecular biology discoveries to multiple FDA-authorized COVID-19 tests and the establishment of several companies. CRISPR-based detection methods are coupled with pre-existing preamplification and readout technologies, achieving sensitivity and reproducibility comparable to the current gold standard nucleic acid detection methods. Moreover, they are very versatile, can be easily implemented to detect emerging pathogens and new clinically relevant mutations, and offer multiplexing capability. The advantages of the CRISPR-based diagnostic approaches are a short sample-to-answer time and no requirement of laboratory settings; they are also much more affordable than current nucleic acid detection procedures. In this review, we summarize the applications and development trends of the CRISPR/Cas13 system in the identification of particular pathogens and mutations and discuss the challenges and future prospects of CRISPR-based diagnostic platforms in biomedicine.
Research Article Genetic diversity among pepper (Capsicum spp.) accessions estimated by microsatellite markers

It is essential that the genetic variability of preserved accessions germplasm banks be evaluated and quantified, which allows, for example, the detection of duplicates, generating more reliable data, especially for groups of plants that have a wide genetic variability, as in the case of the Capsicum genus. We examined the DNA from the leaves of nine accessions of Capsicum spp. from the Federal University of Maranhão Germplasm Bank. Amplification was performed using 78 microsatellite primers previously described as potential molecular markers for Capsicum accessions. Thirty-three microsatellite primers produced amplification products, seven of which were polymorphic and used to investigate genetic variability among nine accessions. The proportion of polymorphic loci in pepper accessions was estimated at 21%. A mean of 2.28 alleles was detected per polymorphic locus and the number of alleles ranged from 1 to 3. The highest effective number of alleles was 1.62, and the highest values of mean observed heterozygosity (Ho) and Shannon's diversity index (I) were 0.533 and 0.421, respectively. Private alleles were detected in two accessions: UFMA17 and UFMA35. The
SYMBIOTIC NITROGEN FIXATION UNDER INTEGRATED ORGANIC-MINERAL NITROGEN APPLICATION ON PEANUT IN SANDY SOIL

A field experiment was conducted on a sandy soil at Ismailia Agricultural Research Station, Ismailia Governorate, Egypt during the summer season of 2016 to study the influence of organo-mineral fertilizer application on nodulation status, yield and yield components of peanut. Four different types of composts originated from different raw materials (cotton stalks, rice straw and bagasse) were integrated with different doses of mineral nitrogen (0, 25, 50 and 100%). Application of any type of compost resulted in enhancement of the nodulation status, plant growth, peanut yield and its components. However, application of rice straw and cotton stalk composts attain the highest values of all the studied parameters. Moreover, the synergy between 50% mineral-N and 50% from any type of compost was superior in all the studied parameters. These fertilization patterns may be considered the most effective strategy for reducing chemical fertilizer, conserving soil fertility and supporting the sustainable agriculture system under sandy soil conditions for producing peanut.
WHAT THEY SAY AND WHAT THEY DO: COMPARING DESTINATION MARKETING ACTIVITIES RELATED TO MOVIE TOURISM IN CROATIA’S ZADAR COUNTY

Purpose – While influence of movies and television on destination image and tourist destination choice is well documented in tourism literature, understanding of the perceptions of destination marketers in movie locations remains an emerging area of inquiry. Consequently, the objectives of this study are: (a) to assess the perceptions of key destination stakeholders regarding the level of integration of movie-induced tourism and destination marketing after a movie's release, and (b) to compare their perceptions to what can actually be observed, in a relatively popular movieshooting destination such as Zadar County (ZC), Croatia. Methodology – Using the Hudson and Ritchie (2006a) model for exploiting movie marketing opportunities, this study employs multimethod research, combining interviews and observation. First, 10 representatives of the tourism and movie industries in ZC are interviewed about the following four factors: movie-induced tourism, marketing activities, branding, and stakeholder involvement. Second, seven tourism-related websites in ZC are analyzed for presence and quality of the movie-related promotional content. Findings – Interviews reveal that key stakeholders (1) embrace the notion of movie-induced tourism, (2) find movie tourism to be well integrated into destination marketing activities, (3) believe that movies are an integral part of ZC's place branding strategy, and (4) perceive that tourism and movie stakeholders actively and systematically collaborate on advancing the movie tourism. However, website content analysis reveals exactly the opposite. Contribution – Theoretically, this research sheds light on the destination marketers' perspectives in regards to movie-induced tourism. Practically, it offers insights on how to tap the potential benefits of movie tourism.
A Novel Coherent Optical Single-carrier Frequency-division-multiplexing (CO-SCFDM) Scheme For Optical Fiber Transmission System

We propose a novel coherent optical single-carrier frequency-division-multiplexing (CO-SCFDM) scheme, which has significantly lower PAPR while achieves high commonality in parameter design with CO-OFDM system. Moreover, orthogonal band multiplexing (OBM) is applicable for CO-SCFDM system.
Analysis of frequently over-threshold subsynchronous oscillation and its suppression by subsynchronous oscillation dynamic suppressor

To mitigate the frequently over-threshold subsynchronous oscillation (FOSSO) phenomenon which occurred in Hulunbuir power plant in the northeast of China, a novel equipment based on voltage source converter (VSC), named subsynchronous oscillation dynamic suppressor (SSODS) is developed and installed. In this study, the root cause of FOSSO is revealed by analysing the response characteristics of the system. Then the control strategy of the developed SSODS is presented. Damping characteristics of SSODS are analysed by the complex torque coefficient method. To verify the effectiveness of the control strategy and the physical controller of VSC, as well as provide initially optimised controller parameters for the field tests, real-time closed-loop tests are carried out. A novel method of torsional modal frequency measure for onsite commissioning test is proposed. The operation and field verification test of SSODS is introduced, and test results demonstrate that SSODS can mitigate the new SSO phenomenon dramatically, proving the validity of SSODS.
Multi-objective surrogate model-based optimization of a small aircraft engine air-intake duct

Aviation industry is constantly striving for more efficient design processes in respect to optimal time, human and computational resources utilization. This implies a need for application of an approximation techniques enabling for fast responses generation with maintained level of results quality. This study focuses on an advancement of aerodynamic shape optimization process of a small aircraft engine intake system by introduction of a surrogate modelling step into the design loop. The multi-objective metamodel assisted optimization is carried out in order to reduce pressure losses along the engine intake duct and increase flow homogeneity at the engine compressor intake plane. Latin Hypercube Design method is utilized in order to sample the design space. A set of initial objective function evaluations is generated with application of Reynolds-averaged Navier–Stokes solver. The ensemble of samples is further used to train a Kriging-based surrogate model. The Efficient Global Optimization algorithm basing on the Expected Improvement function is employed to gradually increase the metamodel prediction quality by usage of sequential sampling technique. Finally, the optimal point predicted by the Kriging surrogate is validated against the high-fidelity model with usage of the Computational Fluid Dynamics code. The paper presents an application of the abovementioned methodology to the design process of the I-31T aircraft turboprop engine intake system. Proposed Kriging-based optimization workflow is utilized in order to reduce pressure losses and improve flow homogeneity in the engine air-intake duct.
Prediction of Alpine Foehn from time series of GNSS troposphere products using machine learning

Abstract. Remote sensing of water vapor using the Global Navigation Satellite System (GNSS) is a well-established technique and reliable data source for Numerical Weather Prediction (NWP). One of the phenomena rarely studied using GNSS are foehn winds. Since foehn winds are associated with significant humidity gradients between lee/luv side of a mountain range, tropospheric estimates from GNSS are also affected by their occurrence. Time series reveal characteristic features like distinctive minima/maxima and significant decrease in correlation between the stations. However, detecting such signals becomes increasingly difficult for large data sets. Therefore, we suggest the application of machine learning algorithms for detection and prediction of foehn events from GNSS troposphere products. The present study uses long-term time series of high-quality GNSS troposphere products from the Automated GNSS Network Switzerland (AGNES) as well as records of operational foehn index to investigate the performance of several different classification algorithms based on appropriate statistical metrics. The two best-performing algorithms are fine-tuned and employed on two years of test data. The results show very promising results, especially when reprocessed GNSS products are utilized. Detection- and alarm-based measures reach levels of 70–85 % for both tested algorithms and thus are comparable to those from studies using data from meteorological stations and NWP. For operational prediction, some limitations due to the availability and quality of GNSS products in near-real time (NRT) exist. However, they might be mitigated to a significant extend by provision of additional NRT products and improved data processing in the future.
Live Recombinant NDV-Vectored H5 Vaccine Protects Chickens and Domestic Ducks From Lethal Infection of the Highly Pathogenic H5N6 Avian Influenza Virus

The H5 subtype highly pathogenic avian influenza virus (HPAIV) has been introduced to South Korea every 2 or 3 years via wild migratory waterfowls, causing devastating damages to the poultry industry. Although most damages and economic losses by HPAIV are focused on chicken layers, domestic ducks are known to play a major role in the farm-to-farm transmission. However, most HPAIV vaccine studies on poultry have been performed with oil-emulsion inactivated vaccines. In this study, we developed a live recombinant Newcastle disease virus (NDV)-vectored vaccine against H5 HPAIV (rK148/ES2-HA) using a previously established NDV vaccine strain (K148/08) isolated from a wild mallard duck. The efficacy of the vaccine when administered via the oculonasal route or as a spray was evaluated against lethal H5 HPAIV infection in domestic ducks and chickens. Oculonasal inoculation of the rK148/ES2-HA in chickens and ducks elicited antibody titers against HPAIV as early as 1 or 2 week after the single dose of vaccination, whereas spray vaccination in ducks elicited antibodies against HPAIV after the booster vaccination. The chickens and ducks vaccinated with rK148/ES2-HA showed high survival rates and low viral shedding after H5N6 HPAIV challenge. Collectively, vaccination with rK148/ES2-HA prevented lethal infection and decreased viral shedding in both chickens and ducks. The vaccine developed in this study could be useful in suppressing the viral shedding in H5 HPAIV outbreaks, with the ease of vaccine application and fast onset of immunity.
A Combination of Chemotherapy and Oncolytic Virotherapy Sensitizes Colorectal Adenocarcinoma to Immune Checkpoint Inhibitors in a cDC1-Dependent Manner

Immune checkpoint therapy has shown great promise in the treatment of cancers with a high mutational burden, such as mismatch repair-deficient colorectal carcinoma (dMMR CRC). However, many patients fail to respond to immune checkpoint therapy. Using a mouse model of dMMR CRC, we demonstrated that tumors can be further sensitized to immune checkpoint therapy by using a combination of low-dose chemotherapy and oncolytic HSV-1. This combination induced the infiltration of CD8+ and CD4+ T cells into the tumor and the upregulation of gene signatures associated with the chemoattraction of myeloid cell subsets. When combined with immune checkpoint therapy, the combination promoted the infiltration of activated type 1 conventional dendritic cells (cDC1s) into the tumor. Furthermore, we found this combination strategy to be dependent on cDC1s, and its therapeutic efficacy to be abrogated in cDC1-deficient Batf3−/− mice. Thus, we demonstrated that the adjuvanticity of dMMR CRCs can be improved by combining low-dose chemotherapy and oncolytic HSV-1 in a cDC1-dependent manner.
Prevalence and Triggering Factors of Childhood Anemia: An Application of Ordinal Logistic Regression Model

Introduction Anemia is indeed a significant risk factor for children's health as it affects growth retardation and has severe short and prolonged effects that follow in morbidity and death. Notwithstanding such ways to tackle anemia, the prevalence remains high in India and poses a severe public health concern. Objectives The primary focus of this study was to find the prevalence and to determine the factors associated with the anemia of children under five years of age in India. Problem Statement. The increasing prevalence of childhood anemia and the life-threatening consequences for millions of children in India are a major concern. Knowing the relevant associated factors with childhood anemia is essential to reduce the frequency and severity level. Study design. For analysis purposes, this study utilized a cross-sectional study design. Methodology. Using the Indian Demographic and Health Survey 2015–16 data, we used chi-squared and gamma tests to find the association. Then, we utilized multinomial logistic regression and ordinal logistic regression to find the better model and the influencing factors of anemia in India. Results In our study, we have found that children with highly educated mothers were 36.7% less likely (OR = 0.633, P ≤ 0.001, 95% CI: 0.608, 0.658) to be higher anemic than the children with not educated mother. Children with moderate and severe anemic mothers were 163.3% (OR = 2.633, P ≤ 0.001, 95% CI: 2.565, 7.704) more likely to be higher anemic than the children with not anemic mother. Not stunting children were 21.9% (OR = 0.781, P ≤ 0.001, 95% CI: 0 .764, 0.797) less likely to be higher anemic than the stunting children. Children aged 36–59 months were 73.9% (OR = 0.361, P ≤ 0.001, 95% CI: 0.353, 0.369) less likely to be higher anemic than the children aged 6–24 months. Again, the ACI value revealed that ordinal logistic regression was a better-fitted model for these data. Conclusion and contribution. The variables such as stunting, underweight, wasting, child age, size of the child, and source of drinking water were the most critical indicators for child anemia in India. In summary, our study result indicated the major socioeconomic and demographic factors associated with childhood anemia in India, which can help the policymaker to take quick decision to reduce the severity level.
Shrinking cities in China: Evidence from the latest two population censuses 2010–2020

As the world's largest developing country, most Chinese cities are experiencing both population shrinkage and spatial expansion in the context of rapid urbanisation. To address the negative impacts of urban shrinkage in a targeted manner, it is necessary to accurately identify shrinking cities in China. In this study, we utilise the sixth and latest seventh population census data to identify and map shrinking cities in China that are experiencing population loss between 2010 and 2020. As a result, we identified 1507 shrinking districts and counties (52% of all 2896 districts and counties in China), with a total area of 4.4 million km2, covering almost 46% of China's territory. In addition, we further found that from 2010 to 2020, there are 266 shrinking cities in China, an increase of 86 (12%) compared with 2000–2010. This indicates that the situation of shrinking cities in China has become more critical. From the perspective of spatial distribution, Chinese shrinking cities are clustered, mainly in the northeast and central regions. We also plot the proportion of shrinkage in a deformed form to reveal which prefecture-level cities are losing population from 2010 to 2020. Our findings provide policymakers and urban planners with a reference and warning that measures should be taken to adjust the growth-oriented planning paradigm to reverse the negative impact of population loss on urban development.
An effective work-function tuning method of nMOSCAP with high-k/metal gate by TiN/TaN double-layer stack thickness

We evaluated the TiN/TaN/TiAl triple-layer to modulate the effective work function (EWF) of a metal gate stack for the n-type metal–oxide–semiconductor (NMOS) devices application by varying the TiN/TaN thickness. In this paper, the effective work function of EWF ranges from 4.22 to 4.56 eV with different thicknesses of TiN and TaN. The thinner TiN and/or thinner in situ TaN capping, the closer to conduction band of silicon the EWF is, which is appropriate for 2-D planar NMOS. Mid-gap work function behavior is observed with thicker TiN, thicker in situ TaN capping, indicating a strong potential candidate of metal gate material for replacement gate processed three-dimensional devices such as FIN shaped field effect transistors. The physical understandings of the sensitivity of EWF to TiN and TaN thickness are proposed. The thicker TiN prevents the Al diffusion then induces the EWF to shift to mid-gap. However, the TaN plays a different role in effective work function tuning from TiN,due to the Ta–O dipoles formed at the interface between the metal gate and the high-k layer.
Effect of Two Distraction Techniques on Children’s Behaviour, Anxiety and Pain in the Dental Setting

Aim: The aim of the current study was to evaluate the influence of using virtual reality (VR) eyeglasses on anxiety and pain perception during pulp therapy treatment in pediatric patients. Methodology: 60 children, aged 4-6 years who were planned to receive vital pulp therapy (pulpotomy) in the mandibular primary molars were randomly divided into two equal groups (30 child per group); an experimental group (non-pharmacological behavior management and VR were used) and a control group (non-pharmacological behavior management was used). The behavior and anxiety of each child were recorded during dental examination, during and after treatment using Frankl behavior rating scale and Venham picture test respectively. Pain perception was recorded using Wong Baker’s face pain scale at end of treatment. Results: There were a significant improvement in the child behavior, pain perception and anxiety score (p<0.05) with use of VR eyeglasses during dental treatment. Conclusion: Results of the current study demonstrated that VR eyeglasses could successfully decrease pain perception, anxiety and improve behavior during dental treatment. KEYWORD: Dental, Child, Anxiety, Pain, Behavior, Distraction, Virtual reality. (22) Aya Naguib Abd El Haleem, et al. E.D. J. Vol. 68, No. 1 as the child’s first dental experience is critical in shaping his or her attitude toward dentistry (Vishwakarma et al., 2017). Preventing pain will improve the dentist-patient relationship, create confidence, reduce fear and anxiety, and improve positive dental attitudes for future visits (Talo et al., 2017). In general, child behavior during dental visits can be managed through non-pharmacological or pharmacological approaches according to situation. Distraction is considered as one of well-used behavioral modification techniques during children dental visits (Anthonappa et al., 2017). Also, VR is considered as a feasible distractive technique for control of child anxiety, pain and behavior during dental visit (Atzori et al., 2018; Koticha et al., 2019). Systematic review of Custodo et al., 2020; Cunningham et al., 2021 demonstrated the limited well-designed clinical trial in assessment of VR effectiveness in anxiety, pain and behavior control for children during dental visits, thus the current study was designed as a step in formation of evidence of VR effusiveness as distractive approach during dental visit. PATIENTS AND METHODS