Miracle-dz/UniFAR-FTUs huggingface dataset:
Alpha B-Crystallin in Muscle Disease Prevention: The Role of Physical Activity

HSPB5 or alpha B-crystallin (CRYAB), originally identified as lens protein, is one of the most widespread and represented of the human small heat shock proteins (sHSPs). It is greatly expressed in tissue with high rates of oxidative metabolism, such as skeletal and cardiac muscles, where HSPB5 dysfunction is associated with a plethora of human diseases. Since HSPB5 has a major role in protecting muscle tissues from the alterations of protein stability (i.e., microfilaments, microtubules, and intermediate filament components), it is not surprising that this sHSP is specifically modulated by exercise. Considering the robust content and the protective function of HSPB5 in striated muscle tissues, as well as its specific response to muscle contraction, it is then realistic to predict a specific role for exercise-induced modulation of HSPB5 in the prevention of muscle diseases caused by protein misfolding. After offering an overview of the current knowledge on HSPB5 structure and function in muscle, this review aims to introduce the reader to the capacity that different exercise modalities have to induce and/or activate HSPB5 to levels sufficient to confer protection, with the potential to prevent or delay skeletal and cardiac muscle disorders.
Chaotic Oscillations in Cascoded and Darlington-Type Amplifier Having Generalized Transistors

This paper describes, based on both numerical and experimental bases, the evolution of chaotic and, in some cases, hyperchaotic attractors within mathematical models of two two-port analog functional blocks commonly used inside radio-frequency systems. The first investigated electronic circuit is known as the cascoded class C amplifier and the second network represents a resonant amplifier with Darlington’s active part. For the analysis of each mentioned block, fundamental configurations that contain coupled generalized bipolar transistors are considered; without driving force or interactions with other lumped circuits. The existence of the structurally stable strange attractors is proved via the high-resolution composition plots of the Lyapunov exponents, numerical sensitivity analysis and captured oscilloscope screenshots.
A Four-Capacitor Model for Interprimary-Winding Capacitances Analysis in the Input-Series Transformer-Integration Converters

The input-series transformer-integration (ISTI) converters are suitable for the high-input voltage multiple-output applications. In these converters, interprimary-winding capacitances are the unique stray capacitances of the integrated transformer, and energy influences of these capacitances cannot be ignored in the high-voltage applications. In order to analyze energy influences of the interprimary-winding capacitances, in this article, a four-capacitor model is proposed to represent these capacitances within arbitrary two primary windings of the integrated transformer. Based on the proposed model, energy varying of the interprimary-winding capacitances is analyzed in detail during each switching period. Furthermore, estimation of the four lumped capacitors is discussed. Finally, three different integrated transformers are designed for a 1-kV/60-W laboratory-made flyback ISTI converter, and validity of the proposed model is verified through the simulating and the experimental comparisons of these integrated transformers.
Initial/final segmentation of Chinese whispered speech based on the auditory model

In this paper, the characteristics of whispered speech are discussed, and a new approach for initial/final segmentation of Chinese whispered speech is proposed on the basis of psychological acoustic theories and experiments. With the mainly four levels of signal processing, this model can represent human's perceptual features of low energy speech, so it is more suitable for the whispered speech recognition. With the experiments of the division between the initial and the final of whispered speech included 386 Chinese syllables at 5dB SNR, the results show that the proposed approach can catch the features of whispered speech more accurately.
The role of older adults in congregational discernment: lessons about LGBTQ+ inclusion

ABSTRACT The role of older adults in Christian congregations is frequently connected to both longevity in the church and financial resources to sustain the work. These two factors can be combined to create a conservative perspective, preservation of the past, and power to influence decisions about change. In a study of 21 congregations across three denominations, the researchers found that while many older adult participants would communicate a negative response to LGBTQ+ inclusion in churches, leadership, and sacraments including marriage, others were committed to and led change, often from a social justice perspective.
A framework to account for flexibility in modeling the value of on-orbit servicing for space systems

The traditional method for maintenance of space systems consists in building reliable satellites through redundancy and replacing them in case of failure, or whenever an upgrade is necessary. On-orbit servicing could change this paradigm. What would be the missions for which servicing would be most interesting, and what price would they be willing to pay for the capability to be serviced? The answer to these questions would provide valuable guidelines as to which servicing technologies to develop, and at what cost. Assuming that the technologies enabling automated servicing are available, traditional metrics and models are first proposed to systematically evaluate servicing cost-effectiveness within a representative trade space of serviceable missions and servicing infrastructures. It is shown that though it can capture some elements of cost-effectiveness, the traditional approach tends to underestimate the value of servicing and demonstrate cost advantages smaller than the cost uncertainty. This issue is solved by then proposing a new approach to on-orbit servicing. First, the intrinsic value of servicing is studied separately from its cost. Furthermore, a first framework to evaluate the flexibility provided by on-orbit servicing to space systems is developed. This framework is used to define models of the value of servicing for two families of space systems faced with different types of uncertainty: commercial systems with uncertain market and military missions with dynamic requirements. For commercial missions with uncertain market, modeling servicing as an option on life extension shows that space systems should not systematically be designed for the longest possible lifetime. Instead, the optimal design life decreases with increasing uncertainty. The maximum servicing price that would make servicing economically interesting is evaluated as a function of uncertainty and the value of flexibility is illustrated on two current examples. For military missions, a small number of satellites with the option to maneuver is considered as an alternative to global coverage for flexibility with respect to contingency location. It is shown that while this alternative has little value in the case of a low Earth orbit radar constellation, it has interesting potential for geostationary communication satellites.
Improvement of Power and Performance in NAND and D-Latch Gates Using CNFET Technology

In this paper, low power and high speed D-latch and nand gates (as sample of combinational and sequential circuits) are designed based on cnfet and cmos technology. The performance of D-latch and nand is compared in two technologies of 65nm and 90nm in cmos and cnfet technology. The circuit designs are simulated using hspice. Finally, the power consumption and delay and pdp as well as rise and fall time are compared in various voltages and frequencies. The results show that cnfetD-latch and nand gates have better delay and power consumption in comparison to cmos technology.
PERFIL DO GESTOR ESPORTIVO BRASILEIRO: UMA REVISÃO DE LITERATURA

A discussao acerca da gestao esportiva e da relevância dos gestores esportivos encontra-se em fase inicial no Brasil, onde ainda nao foram bem definidas algumas de suas caracteristicas, bem como alguns de seus papeis dentro do processo evolutivo do esporte. Portanto, o objetivo deste estudo e aprofundar os conhecimentos acerca do perfil do gestor esportivo em nivel nacional. A pesquisa caracteriza-se por ser um estudo de revisao, para o recolhimento dos dados foram utilizadas as bases eletronicas, onde foram selecionados estudos desenvolvidos no periodo de 2000 a 2013 sobre o perfil do gestor brasileiro. Resultaram 12 estudos, sendo oito artigos originais um artigo de revisao, duas dissertacoes de mestrado e um trabalho de conclusao de curso. Os principais resultados apontaram o perfil das caracteristicas dos gestores, como sendo em sua grande maioria do sexo masculino, com formacao em educacao fisica, e com pouco tempo de experiencia no cargo. Conclui-se que o perfil do gestor no Brasil e pouco estudado, dificultando uma comparacao entre os estudos, o que acaba inibindo o apontamento de algumas caracteristicas que podem ser importantes para definir o cargo de gestor.
Yang-Mills instantons in an asymptotically locally flat background: Taub-NUT vs. Taub-Bolt

We present arguments for the existence of a one-parameter family of self-dual Yang-Mills instantons in the background of Taub-NUT and Taub-Bolt spaces. These solutions are finite everywhere and generically carry a non-integer Pontryagin charge. The Taub-NUT space configurations can be considered as interpolating (when varying the NUT parameter) between the Prasad-Sommerfield and BPST instantons.
Criterios de ubicación de algoritmos de inteligencia computacional en la web de las cosas: Revisión sistemática de la literatura

Objetivo: Determinar y caracterizar el estado actual del conocimiento acerca de los criterios de ubicación del procesamiento de datos, utilizando técnicas de inteligencia computacional en un Ecosistema de Objetos Inteligentes de la Web de las Cosas. Metodología: La revisión sistemática que se presenta a continuación se basa en los estudios realizados por Petersen y Kitchenham , se plantearon cuatro preguntas de investigación, se aplicó el método PICOC para identificar las palabras clave, se planteó una cadena de búsqueda y cuatro motores de búsqueda, se plantearon los criterios de inclusión y exclusión de estudios primarios, así como los criterios de evaluación de la calidad, la estrategia de extracción de datos y el método de síntesis. Resultados: Se lograron responder las cuatro preguntas de investigación planteadas, encontrando que la mayoría de los estudios carecen de una implementación en las tres ubicaciones analizadas y un único estudio que compara el desempeño obtenido por un algoritmo de inteligencia computacional al procesar información en distintas ubicaciones del ecosistema. Conclusiones: Se demostró la necesidad de continuar realizando estudios en el área de la localización del procesamiento en ecosistemas inteligentes utilizando técnicas de inteligencia computacional para el procesamiento en distintas ubicaciones. Además, se evidencia una necesidad en hacer un mayor énfasis en la comparativa del rendimiento obtenido al realizar implementaciones teniendo en cuenta distintas técnicas de inteligencia computacional.
Optimal pathways control fixation of multiple mutations during cancer initiation

Cancer starts after initially healthy tissue cells accumulate several specific mutations or other genetic alterations. The dynamics of tumor formation is a very complex phenomenon due to multiple involved biochemical and biophysical processes. It leads to a very large number of possible pathways on the road to final fixation of all mutations that marks the beginning of the cancer, complicating the understanding of microscopic mechanisms of tumor formation. We present a new theoretical framework of analyzing the cancer initiation dynamics by exploring the properties of effective free-energy landscape of the process. It is argued that although there are many possible pathways for the fixation of all mutations in the system, there are only few dominating pathways on the road to tumor formation. The theoretical approach is explicitly tested in the system with only two mutations using analytical calculations and Monte Carlo computer simulations. Excellent agreement with theoretical predictions is found for a large range of parameters, supporting our hypothesis and allowing us to better understand the mechanisms of cancer initiation. Our theoretical approach clarifies some important aspects of microscopic processes that lead to tumor formation.
Battlestar Galactica est-elle une série féministe ?

in unconventional social roles, accustoming the audience to the idea that they are capable. Such a choral feminism transforms the vision of the gendered division of labor, but the devices used are bound to our fantasies of omnipotence, denying the rough edges of reality and the feminized experience of care, which limits its reach. However, in the final episodes, the fantasies of erasing difference through cloning and interchangeability, and of going beyond the limits of the body through esoteric and transhuman experience, are overshadowed by the representation of the sexuality of ageing and ailing adults as well as a return to the reality of the body’s vulnerability.
Grounding of Modal Conditionals in Agent Systems

W pracy rozpatruje sie zjawisko gruntowania wyrazen jezyka naturalnego w postaci modalnych okresow warunkowych. Modalnośc reprezentowana jest przez trzy operatory modalne: mozliwości, przekonan i wiedzy. Zaklada sie, ze znaczenie tych wyrazen powinno byc zakotwiczone w subiektywnej i niepelnej wiedzy mowcy (agenta). W myśl tego zalozenia proponowany jest oryginalny model realizujący gruntowanie rozpatrywanych wyrazen
Feldenkrais to Improve Interoceptive Processes and Psychological Well-being in Female Adolescent Ballet Dancers: A Feasibility Study

ABSTRACT The Feldenkrais Method® (FM) is a form of somatic education aiming to increase brain-body communication, reportedly via interoceptive mechanisms. Although empirically proven to improve perceived interoceptive ability and psychological well-being in adults, feasibility in adolescents remains unclear. We therefore used a combined randomized control-group pretest-posttest design with qualitative interviews to explore the feasibility of an eight-week FM intervention to enhance interoceptive processes and psychological well-being in a population of adolescent female recreational ballet dancers. Participants’ (N = 12, M age = 14.25 ± 1.29) interoceptive accuracy, perceived interoceptive ability, and psychological well-being were measured pre- and post-intervention, followed by individual interviews. Interview responses demonstrated high enjoyment, increased perceived embodied criticality, and reduced social comparison, supported by a significant increase in self-reported attention regulation (p = .042) in the intervention group. These preliminary findings support the feasibility of FM in this population and thus warrant further research using well-powered randomized controlled trials.
Development of Unified Viscoplastic-Damage Model for Crashworthiness Analysis of Boron Steel Safety Components with Tailored Microstructures

Hot stamped boron steel panels with tailored properties are popular as car safety components for maximised energy absorption. In this study, dynamic and quasi-static tensile tests (strain rate: 0.001/s – 500/s) combined with microstructural observation were carried out to study the mechanical properties of press hardened boron steel with various microstructures (martensite volume fraction: 0 – 100%) at room temperature. Based on the test results, a physically-based unified viscoplastic-damage constitutive model has been developed and determined, which takes the volume fraction of martensite into account. Thus the crashworthiness and failure mode of boron steel parts having graded microstructure distributions can be described through a single set of equations.
Physiological and Genomic Characterization of Two Novel Bacteroidota Strains Asinibacterium spp. OR43 and OR53

Asinibacterium spp. (Family Chitinophagaceae, Phylum Bacteroidota) are abundant in environments contaminated with heavy metals. We characterized the physiology and genome of two Asinibacterium species to elucidate their ability to survive and grow at ambient conditions in the uranium-contaminated environments. Both strains were able to grow at pH 4.5 or 50 mM nitrate under aerobic conditions and did not grow with alternative electron acceptors under anaerobic conditions. Asinibacterium sp. OR53 grew in medium with uranium concentrations up to 300 µM uranium while Asinibacterium sp. OR43 could not grow at uranium concentrations > 200 µM. Elemental mapping using energy dispersive X-ray spectroscopy indicate that uranium co-localized with phosphorus-containing compounds on the cell surface. Genes potentially encoding resistance mechanisms to a variety of heavy metals were detected in the genomes of both strains. The localization of uranium and missing acidic and alkaline phosphatase genes in the genome suggest that biosorption of uranium to the lipopolysaccharide layer might be the mechanism of uranium resistance. In summary, Asinibacterium spp. OR43 and OR53 are physiologically similar to closely related strains within the Chitinophagaceae family but are uniquely acclimated to the presence of uranium and other heavy metals prevalent in the subsurface at Oak Ridge, Tennessee.
Efficacy of Clinical Guidelines in Identifying All Japanese Patients with Hereditary Breast and Ovarian Cancer

Clinical screening using the National Comprehensive Cancer Network (NCCN) testing criteria may fail to identify all patients with hereditary breast and ovarian cancers. Thus, this study aimed to evaluate the strategy of expanding target patients for genetic testing among Japanese patients. We reviewed the medical records of 91 breast cancer patients who underwent genetic testing. Among 91 patients, eight were diagnosed with pathogenic or likely pathogenic variants: BRCA1 (n = 4) and BRCA2 (n = 4). Among 50 patients meeting the testing criteria of the guidelines, 6 (12%) were diagnosed with pathogenic or likely pathogenic variants. The sensitivity and specificity of screening using the testing criteria were 75% and 47%, respectively. Expanding the NCCN criteria to include all women diagnosed with breast cancer aged ≤65 years achieved 88% sensitivity but 8% specificity. The expansion of the NCCN criteria could benefit Japanese patients; however, larger studies are necessary to change clinical practice.
Functional ecosystem parameters: Soil respiration and diversity of mite (Acari, Mesostigmata) communities after disturbance in a Late Cambrian bedrock environment

We analyzed the changes in ecosystem functions (soil respiration and Mesostigmata mite abundance, species richness and diversity) on various habitats after flooding by highly mineralized and acidic drainage water with fine As‐rich pyrite sediments, on a fragment of a natural ecosystem. In total, 177 plots that represented six types of habitats (undisturbed: pine mixed forests, Salix spp. thickets, Juncus effusus communities, wet meadows, and disturbed: bare ground and dead Salix spp. thickets) were sampled twice, in June 2019 and September 2020. Our study revealed that flooding affected essential ecosystem parameters, such as soil Mesostigmata mite abundance, species richness and diversity, and soil respiration, via an extreme decrease of soil pH. In total, 968 mites were collected from pooled data from the two samplings. Mite abundance, species richness and diversity were mainly shaped by habitat type and soil pH, and partially by soil respiration. These parameters were lower in disturbed habitats (bare ground and dead Salix spp. thickets) as compared with undisturbed ones. The highest mean mite density was recorded from mixed forests (4750 ± 600 ind. m−2) and wet meadows (2678 ± 361 ind. m−2), whereas the lowest in bare ground (449 ± 113 ind. m−2) and dead Salix spp. thickets (537 ± 146 ind. m−2). We noticed that mite diversity may be helpful to predict future changes in the physicochemical parameters of soils in disturbed areas. The vegetation patches built up by species adapted to grow in habitats characterized by relatively high metal and metalloid content (J. effusus and Salix spp.) represent an intermediate state of function of ecosystems in the study area.
Temporal Modulation of Drug Desensitization Procedures

Drug hypersensitivity reactions are an unavoidable clinical consequence of the presence of new therapeutic agents. These adverse reactions concern patients afflicted with infectious diseases (e.g., hypersensitivity to antibiotics), and with non-infectious chronic diseases, such as in cancers, diabetes or cystic fibrosis treatments, and may occur at the first drug administration or after repeated exposures. Here we revise recent key studies on the mechanisms underlying the desensitization protocols, and propose an additional temporal regulation layer that is based on the circadian control of the signaling pathway involved and on the modulation of the memory effects established by the desensitization procedures.
Enhanced convergence of periodic potentials in stratified media through asymptotic extractions

1 Sorbonne Universites, UPMC Univ Paris 06, UR2, L2E, F-75005, Paris, France, guido.valerio@upmc.fr 2 Maxtena Inc., Bethesda, MD 20814 USA, s.paulotto@gmail.com 3 Department of Information Engineering, Electronics and Telecommunications, Sapienza University of Rome, 00184, Rome, Italy, baccarelli@diet.uniroma1. it, galli@diet.uniroma1. it 4 Department of Electrical and Computer Engineering, University of Houston, Houston, TX 77204-4005 USA, wilton@uh.edu, djackson@uh.edu 5 Electromagnetics consultant, Albuquerque, NM 87123-2421 USA, w.johnson24@comcast.net
Experimental studies on condensed-phase ineractions of hypergolic propellants

Current research is focused on the development of novel experimental techniques that can be used to obtain an understanding of the physical and chemical processes during the condensed-phase interaction of hypergolic pairs. A drop test setup, coupled with a high speed camera, was developed to conduct time-resolved studies on the pre-ignition, ignition and post-ignition events during the drop-on-pool impingement interactions of two hypergolic liquids. Thin-wire thermocouples were used to trace the temperatures of the liquid reactants as well as the gaseous products formed during the pre-ignition process which has a very short time scale. In addition, a confined interaction setup, coupled with rapid scan Fourier transform infrared (FTIR) spectroscopy, was developed to study the gaseous species evolved from the early reactions that occur upon the mixing of small quantity of liquid hypergols. One major objective of this research is to develop an understanding of the preignition reactions between the oxidizer nitric acid (HNO3) and two target fuels: monomethylhydrazine (MMH), one of the most well-known hydrazine-based fuels, and N,N,N,’N’-tetramethylethylenediamine (TMEDA), which may be one of the most promising alternative fuels. This is also a part of an effort to provide experimental support for the MMH-RFNA and TMEDA-RFNA mechanisms that are being developed by the Army Research Laboratory (ARL). A three-stage hypergolic ignition process was revealed by both the temperature measurements in the drop tests and the pre-ignition products analysis in the confined
A PULSATING WATER TUNNEL

Since the basic mechanism of sand transportation in wave motion is so far unknown, there is a great need for observations of such transportation in large waves, especially, because of the possible difference of transportation in prototype wave motion from that in small model waves. By means of the apparatus described in the present paper the water and sediment motion near the bed can be reproduced on a prototype scale with the only modification that velocities at all points are in phase.