Miracle-dz/UniFAR-FTUs huggingface dataset:
STUDY OF ANTHELMINTIC AND ANTIMICROBIAL ACTIVITY OF PEEL EXTRACT OF PUNICA GRANATUM LINN

Punica granatum linn. (pomegranate) has been used for centuries to confer health benefits in number of diseases . The aim of present study is to identify phytochemical constituents and evaluation of antimicrobial and anthelmintic activities of peel extract of pomegranate. Antimicrobial activity of plant is due to its secondary metabolites. The antimicrobial activity of peel extract in aqueous, ethanol and methanol on E.coli, S.aureus, and B.subtilis was studied at different concentrations (1, 5, 10 mg/ ml). E. coli shows significant zone of inhibition in ethanol extract and S.aureus in aqueous extract, while B. subtilis shows in methanolic extract.The various concentrations (20, 50, 100, and 150 mg/ml) of aqueous, methanol and ethanol extracts were tested in-vitro for anthelmintic potency. It was determined by time required for paralysis and time required for death of earth worms. The peel extract shows dose dependant activity . The short time for paralysis and death was observed for methanol extract at concentration 150 mg/ml. From above observations it was concluded that the methanolic extract shows maximum response in dose dependant manner for antimicrobial and anthelmintic activities.
Right ventricular dysfunction in patients with non- severe idiopathic pulmonary brosis: a cross- sectional prospective single-center study

Sandra de Barros Cobra (  sandrab.cobra@gmail.com ) University of Brasilia https://orcid.org/0000-0003-0837-339X Marcelo Palmeira Rodrigues University of Brasilia Felipe Xavier de Melo University of Brasilia Nathali Mireise Costa Ferreira University of Brasilia Viviane Vieira Passini Soares University of Brasilia Verônica Moreira Amado University of Brasilia César Augusto Melo e Silva University of Brasilia
Recent developments in the physiology and pharmacology of 5 -hydroxy tryptamine

During the past four decades there has been a resurgence of interest in biological amines, in particular 5-hydroxytryptamine (5-HT) and its close relatives. The development of radioligand techniques in the 1980s and their application to amine research has led to increased understanding of the anatomical location of 5-HT neurones, the physiological function of endogenous 5-HT and the effects on different tissues of exogenously applied 5-HT. The pharmacology of 5-HT and 5-HT-type drugs, based on in vitro and in vivo studies, has led to a comprehensive and expanding classification of 5-HT receptors, achieved predominantly by using the growing population of selective 5-HT agonistantagonist ligands as tools. Understanding of the complexities of 5-HT physiology and pharmacology will allow the development of a rational therapeutic approach to various 5-HT-based pathologies such as nausea, migraine, hypertension, gastric stasis disorders and others.
Community Memory of COVID-19 Infections Post Lockdown as a Surrogate for Incubation Time

If the knowledge of the incubation time is helpful in designing non-pharmaceutical interventions such as quarantine measures, can one use the number of cases arising after a lockdown to check (a) if our assumptions of the incubation time were correct and (b) if the quarantine measures were as successful as they could theoretically be. These are the two questions we raise by studying the number of new cases arising after lockdowns in a few European countries. The analysis which purely relies on the publicly available data of the numbers of new infections, rather than extensive contact tracing of individual patients, suggests a “memory” of the infections in the community with a median of 13.3 days. This distribution of the memory of infections which may even be considered as a surrogate of the incubation time in a perfect lockdown, suggests that even a perfect quarantine of 30 days is only 90% complete.
The Cyclin-Dependent Kinase Inhibitor p27kip1 Is Required for Transplantation Tolerance Induced by Costimulatory Blockade1

The cyclin-dependent kinase (CDK) inhibitor p27kip1 is an important negative regulator of the cell cycle that sets a threshold for mitogenic signals in T lymphocytes, and is required for T cell anergy in vitro. To determine whether p27kip1 is required for tolerance in vivo, we performed cardiac allograft transplantation under conditions of combined CD28/CD40L costimulatory blockade. Although this treatment induced long-term allograft survival in wild-type recipients, costimulatory blockade was no longer sufficient to induce tolerance in mice lacking p27kip1. Rejected allografts from p27kip1−/− mice contained more CD4+ T lymphocytes and exhibited more tissue damage than allografts from tolerant, wild-type mice. Infiltrating p27kip1-deficient T cells, but not wild-type T cells, exhibited nuclear expression of cyclins E and A, indicating uncontrolled T cell cycle progression in the graft. The failure of tolerance in p27kip1−/− mice was also accompanied by markedly increased numbers of allospecific, IFN-γ-producing cells in the periphery, and occurred despite apparently normal regulatory T cell activity. These data demonstrate that the CDK inhibitor p27kip1 enforces the costimulatory requirement for the expansion and differentiation of alloimmune effector T lymphocytes in vivo, and point to CDKs as novel targets for immunosuppressive or tolerance-inducing therapies.
OTT_A_239789 3987..3998

Department of Gastrointestinal Surgery, Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, People’s Republic of China Background: Circular RNAs (circRNAs) have been proven to play important roles in tumorigenesis. However, the mechanism by which circRNAs act on gastric cancer (GC) through epithelial-to-mesenchymal transition (EMT) is unclear. In this study, we identified circ-OXCT1 and elucidated its function on EMT in GC. Methods: Tissue circRNA microarray analysis and qRT-PCR were utilized to determine the expression level of circ-OXCT1 in GC. Luciferase reporter assay and FISH were employed to confirm the interaction between circ-OXCT1 and miR-136. CCK-8, cloning formation, transwell, wound healing, nude mice experiment, circ-OXCT1 overexpression and silencing were conducted to elucidate the function of circ-OXCT1 in vivo and in vitro. Western blot and rescue experiment were carried out to evaluate the changes of EMT-related proteins induced by circ-OXCT1 overexpression or silencing. Results: Circ-OXCT1 was downregulated in GC tissues and cell lines. Its expression level was significantly associated with lymph node metastasis, pathologic stage and overall survival rate through clinicopathologic data analysis. Circ-OXCT1 silencing downregulated SMAD4 expression and accordingly regulated expression of E-cadherin, N-cadherin and vimentin through the transforming growth factor-beta (TGF-β)/Smad signaling pathway by a circ-OXCT1/miR-136/SMAD4 axis, resulting in enhancement of EMT and subsequent boost of cell migration, invasion and nude mice lung metastasis. Conclusion: Our data showed that circ-OXCT1 suppresses gastric cancer EMT and metastasis through TGF-β/Smad signaling pathway. The clinicopathologic data analysis revealed that circ-OXCT1 overexpression could be a novel treatment for advanced GC especially with distant metastasis by targeting the circ-OXCT1/miR-136/SMAD4 axis.
The management of a positional default of atlas in a patient with cervicogenic headache: A case report

Received: September 27, 2015; Accepted: October 17, 2015; Published: October 19, 2015 Cervicogenic headache (CH) is a unilateral headache that can spread to the frontaltemporal and orbital regions and has been defined by the International Headache Society as “pain, referred from a source in the neck” [1]. The prevalence of CH is around 4% in the general population ranging from 15% to 20% of all headaches [2-4]. Although the exact mechanism remains elusive, there appears to be a correlation between mechanical dysfunction of the high cervical spine and the development of CH [4-7].
Wind Power Trading with Variable Demand in Deregulated Electricity Market

In the emerging electricity markets, a suitable trading mechanism is required to accommodate the wind power generations to recover their costs. This paper presents various market strategies in a competitive power market having wind generators. Till now, wind power trading studies has been done on the basis of fixed demand. In real life scenario fixed demand doesn’t exist. In this paper a practical approach is proposed by taking variable demand. Market clearing price has been analyzed in both supply side and demand side bidding scenarios for bid trading models. Wind power can also play a vital role in ancillary services and mitigating the market power, but their costs must be recovered for successful promotion. Trading with wind power must be transparent for free and fair trade of electricity. An MCP index has been modeled to give indication of the MCP variations. This paper can be a guideline for the policy makers and Market Operators to promote the wind power with system transparency. Calculations have been done with the help of MATRIX LABORATORY. KeyTerms—Competitive power market, Bidding, Market clearing price (MCP), MCP Index
An Improved Differential Evolution Algorithm with Novel Mutation Strategy

: Aiming at the defects of differential evolution, such as premature convergence, low accuracy and other shortcomings, an improved differential evolution algorithm with novel mutation strategy(NMSIDE) is presented. The novel mutation strategy is used to avoid being trapped into local minima for NMSIDE. If the evolution of the individual stagnates, the individual will rely on the current best individual to move closer to the global best individual. The mutation rate varies dynamically within the range of values, and the crossover rate is dynamically varied based on the number of iterations. NMSIDE is tested on 11 standard functions and compared with the other state-of-the-art algorithms. The experimental results show that NMSIDE has higher convergence precision, faster convergence speed and better robustness.
A Novel Multitarget Mu- and Delta-Opioid Receptors Agonist HAGD Has Peripherally Restrictive Potent Analgesia with Less Side Effects in Mice and Minimal Impact on Human Sperm Motility

Li FangFang Lanzhou University https://orcid.org/0000-0003-3446-1289 Feng Yue Lanzhou University First A liated Hospital Wei Zhang Lanzhou University First A liated Hospital Biao Xu Lanzhou University School of Basic Medical Sciences Shi-Qiang Han Linxia Hui Autonomous Prefecture Maternity and Childcare Hospital Yi-Qing Wang Lanzhou University First A liated Hospital Xue-Hong Zhang (  zhangxueh@lzu.edu.cn ) Lanzhou University First A liated Hospital
EXPLORING THE EARLY ANTHROPOCENE: IMPLICATIONS FROM THE LONG-TERM HUMAN– CLIMATE INTERACTIONS IN EARLY CHINA

Because human modification has been significant enough to alter the atmospheric chemistry, some scholars argue that our planet Earth is going beyond the Holocene and coming into a new geological epoch, the Anthropocene. While the Anthropocene concept is widely acknowledged, some key issues, such as the starting point of this epoch and how humans influenced climate, are unclear. This paper provides an overview of the long-term, broad-scale interactions between climate evolution and increasingly intensive human activities (mainly farming) in Early China. It firstly reviews both the traditional “climate in charge” hypothesis and Ruddiman’s “anthropogenic greenhouse gases” hypothesis. Then pollen and isotope data on paleo-climate is summarized to shed light on the climatic history in China from ~3500 BCE to ~220 CE. It is followed by an overview of the cultural history within the same time span. Finally, by integrating these two lines of evidence, the dynamic process of the interplay of human activity (particularly farming) and climate is synthetically discussed. Based on the evidence, I argue that the onset of the Anthropocene is a prolonged process with a notable mark in the early centuries CE.
A FEA-based design of 3D printed scaffolds to assist post- surgical bone growth via tissue engineering

Xu Huang a, ; Donna C. Jones ; Zimo Zhu ; Gui-Rong Liu ; John A. van Aalst ; Sajjad Soleimani; Jacob Knorr ; Zhengyuan Shan ; Montserrat Caballero c and Chia-Ying James Lin a Aerospace Engineering & Engineering Mechanics, University of Cincinnati, Cincinnati, b Materials Science and Engineering, University of Cincinnati, Cincinnati, Ohio, USA; c Division of Plastic Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, USA d Biomedical Engineering, University of Cincinnati, Cincinnati, USA
Reactivation of Bovine Tuberculosis in Patient Treated with Infliximab, Switzerland

1. Nattermann H, Horsch F. The Corynebacterium pyogenes infection in cattle. I. Incidence of the pathogen [in German]. Arch Exp Veterinarmed. 1977;31:405–13. 2. Ide A, Decostere A, Stuer P, Stuer E, De Laere A, Verlinde T, et al. Arcanobacterium pyogenes spondylodiscitis in a veterinary surgeon: plea for cooperation between medical and veterinary microbiologists in identification of causal agents of zoonotic infections. Clin Microbiol News. 2006;28:163–7. DOI: 10.1016/j. clinmicnews.2006. 10.004 3. Plamondon M, Martinez G, Raynal L, Touchette M, Valiquette L. A fatal case of Arcanobacterium pyogenes endocarditis in a man with no identified animal contact: case report and review of the literature. Eur J Clin Microbiol Infect Dis. 2007;26:663–6. DOI: 10.1007/s10096007-0354-9 4. Hermida Ameijeras A, Romero Jung P, Cabarcos Ortiz de Barron A, Treviño Castallo M. One case of pneumonia with Arcanobacterium pyogenes [in Spanish]. An Med Interna (Madrid). 2004;21:334–6. 5. Altschul SF, Madden TL, Schäffer AA, Zhang J, Zhang Z, Miller W, et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997;25:3389–402. DOI: 10.1093/nar/25.17. 3389 6. Tamura K, Dudley J, Nei M, Kumar S. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol. 2007;24:1596–9. DOI: 10.1093/molbev/msm092 7. Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG. The CLUSTAL X Windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 1997;25:4876–4882. DOI: 10.1093/ nar/25.24. 4876 8. Saitou N, Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol. 1987;4:406–25. 9. Felsenstein J. Confidence limits on phylogenies: an approach using the bootstrap. Evolution Int J Org Evolution. 1985;39:783–9. 10. Yoshimura H, Kojima A, Ishimaru M. Antimicrobial susceptibility of Arcanobacterium pyogenes isolated from cattle and pigs. J Vet Med. 2000;47:139–43. DOI: 10.1046/j.1439-0450.2000. 00315.x
Corpus Callosum Shape Changes in Early Alzheimer’s Disease: An MRI Study Using the Automatic Deformable Model

— In this paper, we propose a solution to diagnose Alzheimer's pathology; we are interested in changing the shape of the Corpus Callosum (CC). It is the commissure of the brain and Alzheimer diseases manifests by a significant reduction of its volume. To do this, we used a classification method based on decision trees and the Active Shape Model (ASM) to extract the lesion study. For the deformable model, we added the following contribution: integration of a priori knowledge to automate the initialization of the average shape. For the pretreatment step, we used the median filter. Our method is validated by a physician to diagnose Alzheimer's disease.
Original Contribution Fruit and Vegetable Intakes and Risk of Colorectal Cancer in the NIH–AARP Diet and Health Study

The authors examined the associations between fruit and vegetable intakes and risk of colorectal cancer in the NIH–AARP Diet and Health Study. Diet was assessed with a food frequency questionnaire at baseline. Relative risks and 95% confidence intervals were estimated by using the Cox proportional hazards model. During 5-year follow-up of 488,043 men and women aged 50–71 years, 2,972 incident colorectal cancer cases were identified. The respective 10th and 90th percentiles of total fruit and vegetable intake (servings/1,000 kcal per day) were 1.4 and 5.2 for men and 1.8 and 6.5 for women. Compared with that for the lowest quintile of vegetable intake, the multivariate relative risk for the highest quintile was 0.82 (95% confidence interval: 0.71, 0.94) for men and 1.12 (95% confidence interval: 0.90, 1.38) for women. Increased risk of colorectal cancer was observed for very low intake of total fruits and vegetables by men (multivariate relative risk for <1 vs. 2.0 servings/1,000 kcal per day 1⁄4 1.26, 95% confidence interval: 1.03, 1.54). Among subgroups of vegetables, green leafy vegetables were associated with a lower risk of colorectal cancer for men (multivariate relative risk for the highest quintile vs. the lowest 1⁄4 0.86, 95% confidence interval: 0.74, 0.99). Intake of fruits was not related to risk of colorectal cancer in men or women.
Prevalence and Predictors of Central line Associated Infection in Jordanian Adult Patients hospitalized in Intensive Care Units

Background. Central line associated blood stream infection is one of the main oncerns worldwide. Reduction of this problem is the main goal of nurses working in intensive care units to improve patients’ safety and quality of care. Little is known about the endemic burden of this problem in developing countris. Aims and Objectives. This study aimed to estimate the prevalence of central line associated bloodstream infection in adult patients hospitalized in intensive care units, in Jordan. Moreover, the study aimed at identifying significant predictors of central line associated bloodstream infection. Methods. A retrospective design was used. The setting of this study was a University affiliated hospital in northern Jordan. Data from 300 medical records for adult patients hospitalized in intensive care units of the selected hospital, during the period from 1st January 2014 to 1st December 2015 were retrieved and recorded using researchers developed tools. Results. The prevalence of central line-association bloodstream infection in intensive care units was 17.7 per 1000 central line days. Smoking, respiratory related disorders, blood transfusion, femoral site of central venous catheter significantly predicted the infection. Conclusion. Assessment for risk factors contributing to infection in patients hospitalized in intensive care units is essential to build nursing care strategies targeting risky groups. Furthermore, establishing a national-wide surveillance programs at hospitals of national and regional levels to prevent such infection in intensive care units are required. INTERNATIONAL JOURNAL OF HEALTHCARE TECHNOLOGY AND MANAGEMENT Article ID: IJHTM_08_26_001 (Online) ISSN: 1741-5144 (Print) ISSN: 1368-2156 VOLUME 2017, ISSUE 5, JULY – AUGUST Available Online at https://www.ijmrnd. com/journal/international-journal-of-healthcaretechnology-and-management/ © IJMRND Publications International Journals of Modern Research & Development (IJMRND) Page 2
Antibodies Bind to DNase I By

Polyspecificity is a well-known property of the anti-DNA antibodies produced by autoimmune animals. In our search for antigen targets of anti-DNA antibodies within tissue extracts, we identified a 32-kD polypeptide that was recognized by a large panel of anti-DNA antibodies. Direct sequencing of this protein disclosed its identity with DNase I. 22 monoclonal anti-DNA antibodies bound to DNase I in direct and competitive immunoassays; out of 15 autoantibodies that did not bind DNA, none had the ability to bind DNase I. The ability of anti-DNA antibodies to interfere with DNase I enzymatic activity was evaluated in an assay based on the enzyme digestion of phage double strand DNA. Six monoclonal anti-single strand DNA antibodies that did not bind double strand DNA were tested in this assay. Three out of six inhibited DNase I-mediated digestion of phage DNA. The interaction of anti-DNA antibodies with DNase I was further investigated by testing their ability to bind a synthetic peptide that corresponds to the catalytic site of the molecule. 4 out of 22 anti-DNA antibodies bound the active site peptide; two of these had been shown to inhibit DNase I enzymatic activity. This report shows that anti-DNA antibodies recognize both DNA and its natural ligand DNase I. Some anti-DNA antibodies inhibit DNase I enzymatic activity, thus displaying the potential to modulate DNA catabolism. The dual specificity of anti-DNA antibodies offers a clue for understanding the mechanisms that lead to anti-DNA antibody production in autoimmune animals.
Study and implementation of self-adaptive structures

A new and variable micro structure to change spatially and temporally the capacity of local heat removal through selfadaptive longitudinal vortex generators (LVGs) are studied in this project. The ideal solution is that LVGs move in function of substrate temperature. Therefore, it is very important to obtain the highest tip deflection of the micro structures to create more turbulence within a micro channel (MC) increasing the heat transfer between the coolant and the hot zone. The results show the highest tip deflection was achieved in bimetallic micro structures, approximately 50μm. However, in triangular micro structures the highest tip deflection was lower than 1μm. A comparison between all the designs was made to see the best self-adaptive structure within a MC to improve the heat transfer enhancement.
Auditory vertical localization in the median plane with conflicting spectral and dynamic cues

Both spectral and dynamic cues provide information for front-back and vertical localization. However, the relative importance of two cues to vertical localization is still unclear. The spectral cue has conventionally been regarded as a dominant one and the contribution of dynamic cue was often neglected. In present work, a psychoacoustic experiment was conducted to examine the relative importance of spectral and dynamic cues to vertical localization in the median plane. By modifying the headrelated transfer functions (HRTFs) used in a dynamic virtual auditory display, binaural signals with conflicting spectral cue and dynamic variation of interaural time difference (ITD) were created and presented by headphone. Results indicated that dynamic cue dominates the vertical localization below the frequency of 3 kHz, and the spectral cue dominates the vertical localization above the frequency of 3 kHz. For stimuli with full audible bandwidth, conflicting spectral and dynamic cues results in two splitting auditory events or perceived virtual sources corresponding to different frequency band. The vertical positions of high-frequency and low-frequency virtual source are consistent with the spectral cue and dynamic cues, respectively. Therefore, both spectral and dynamic cues are important to vertical localization but each is effective at different frequency range.
and Fauna and setting of the Adelolophus hutchisoni type locality in the Upper Cretaceous (Campanian) Wahweap Formation of Utah

We report new data on the type locality of the hadrosaurid ornithischian Adelolophus hutchisoni Gates et al., 2014 from the Campanian-aged Wahweap Formation of southern Utah, and the remainder of the vertebrate assemblage from the site. The type locality (UCMP V98173) is a previously-reported U.S. Geological Survey locality (USGS D815) and is stratigraphically low in the upper member of the Wahweap Formation. Additional taxa from the same site include acipenseriforms (sturgeon), amiiforms (bowfin), and lepisosteiforms (gar fish), baenid and trionychid turtles, and both theropod and ornithischian dinosaurs.