Miracle-dz/UniFAR-FTUs huggingface dataset:
PARP1 Inhibition Halts EBV+ Lymphoma Progression by Disrupting the EBNA2/MYC Axis

PARP1 has been shown to regulate EBV latency. However, the therapeutic effect of PARP1 inhibitors on EBV+ lymphomagenesis has not yet been explored. Here, we show that PARPi BMN-673 has a potent anti-tumor effect on EBV-driven LCL in a mouse xenograft model. We found that PARP1 inhibition induces a dramatic transcriptional reprogramming of LCLs driven largely by the reduction of the MYC oncogene expression and dysregulation of MYC targets, both in vivo and in vitro. PARP1 inhibition also reduced the expression of viral oncoprotein EBNA2, which we previously demonstrated depends on PARP1 for activation of MYC. Further, we show that PARP1 inhibition blocks the chromatin association of MYC, EBNA2, and tumor suppressor p53. Overall, our study strengthens the central role of PARP1 in EBV malignant transformation and identifies the EBNA2/MYC pathway as a target of PARP1 inhibitors and its utility for the treatment of EBNA2-driven EBV-associated cancers. Significance Statement A promising approach to treating EBV-driven malignancies involves targeting cancer and EBV biology. However, investigating host factors that co-regulate EBV latent gene expression, such as PARP1, has been incomplete. Our study demonstrates that the PARP1 inhibitor BMN-673 effectively reduces EBV-driven tumors and metastasis in an LCL xenograft model. Additionally, we have identified potential dysregulated mechanisms associated with PARP1 inhibition. These findings strengthen the role of PARP1 in EBV+ lymphomas and establish a link between PARP1 and the EBNA2/MYC axis. This has important implications for developing therapeutic approaches to various EBV-associated malignancies.
Illumination Invariant Face Recognition Using Gabor Wavelet Function

Illumination variation changes the appearance of faces and makes it very difficult for accurate recognition. Face recognition in an uncontrolled environment is still a challenging task for the researcher. In this paper, we propose a Fourier transform (FT) based illumination normalization and Gabor wavelets based feature extraction for proper face representation for better classification. Implementing FT and Gabor wavelets in this method is to make the system more robust to the various constraints like illumination and noise where the performances of the other systems are degraded. Considering the phase magnitude information in the frequency domain, the illumination is compensated and using the Gabor filters noise and other unwanted disturbances like facial expressions are discarded. The extensive experimental results, on the publicly available Extended Yale-B face database, show that the proposed method performs better than the well known systems even if on the extremely poor illumination images.
Job standardization as a mediator of the using information technologies impact on employee efficiency

The content of work in all types of workplaces has been intensively changing in the last few decades, especially in the part of the way of doing work and increasing efficiency. The mentioned dynamic of changes is caused by alters in the technical system that is increasingly relying on information technology and automation systems, where today one person can perform in certain areas the same amount of work that was previously performed by dozens of employees. Standardization at the time of the fourth technological revolution, can be used to a certain extent to improve the efficiency of the work of employees in all areas and industries, whether it is production or service, but with different intensity. The aim of the paper is to test the mediating influence of job standardization on employee efficiency if the key outputs of the job analysis process are observed as predictors. The paper will test the impact of job analysis segments including information technology using intensity on employee efficiency in the context of the fourth technological revolution and digitalization, directly and indirectly through the mediation of job standardization construct. In the above way, we want to find out the answer to the question of how important the standardization of work is as a vehicle for the efficiency of employees in modern business conditions that require acceptance of the principle of deviating from the standard job description and procedures (dejobbing), which to a certain extent is in logical collision with the standardization of work.
Dual mechanism of photoresponse in composite Si–Au nanolayers on crystalline silicon

Silicon‐based structures comprised of crystalline silicon substrates and active layers of mixed silicon and gold nanoparticles were fabricated and characterized. Several layer compositions were studied. The investigated structures demonstrate very large spectral sensitivity (more than 10 A W−1) in the wide spectral range (400–1000 nm). Such large sensitivity implies presence of photocurrent amplification. A model which involves dual mechanism of the photoresponse was proposed in order to explain the appearance of the photocurrent amplification in the investigated structures.
Terminal regions of a protein are a hotspot for low complexity regions (LCRs) and selection

A majority of the protein-coding genes consist of low-complexity regions (LCRs) in eukaryotes. Volatile LCRs are a novel source of adaptive variation, functional diversification, and evolutionary novelty. LCRs contribute to a wide range of neurodegenerative disorders. Conversely, these regions also play a pivotal role in critical cellular functions, such as morphogenesis, signaling, and transcriptional regulation. An interplay of selection and mutation governs the composition and length of LCRs. High %GC and mutations provide length variability because of mechanisms like replication slippage. The selection is nearly neutral for expansion/contraction within the normal range and purifying above a critical length. Because of the complex dynamics between selection and mutation, we need a better understanding of the coexistence and mechanisms of the two. Our findings indicate that site-specific positive selection and LCRs prefer the terminal regions of a gene and co-occur in most of the Tetrapoda clades. Interestingly, positively selected sites (PSS) are significantly favored in LCRs in eight of the twelve clades studied. We also observed a significant favor of PSSs in the polyQ region of MAML2 in five clades. We also found that PSSs in a gene have position-specific roles. Terminal-PSS genes are enriched for adenyl nucleotide binding, while central-PSS genes are involved in glycosaminoglycan binding. Moreover, central-PSS genes mainly participate in defense responses, but terminal-PSS genes are non-specific. LCR-containing genes have a significantly higher %GC and lower ω (dN/dS) than genes without repeats across the Tetrapoda clade. A lower ω suggests that even though LCRs provide rapid functional diversity, LCR-containing genes face intense purifying selection.
Flavonoid glycoside constituents of the leaves of Solanum melongena collected in Thua Thien Hue and their anti-inflammatory activity

Solanum melongena is a member of Solanum genus that widely cultivated as fruit vegetable in Vietnam. According to Vietnamese traditional medicine, the fruits and whole plants are used to treat toothache, turgescence, pruritus, and haemorrhoids. As part of our project to study the chemical composition and bioactivity of Solanum genus in Vietnam, five flavonoid glycosides including kaempferol-3-O-β-D-glucopyranoside (1), isovitexin (2), kaempferol 3-O-β-D-glucoside-7-O-α-L-rhamnoside (3), kaempferol 3-O-β-D-sophoroside-7-O-α-L-rhamnoside (4), and kaempferol 3-O-β-D-sophoroside (5) were isolated from the methanol extract of the leaves of Solanum melongenagrowing in Thua Thien Hue province, by using various chromatography methods. Their chemical structures were determined by detailed analysis of 1D- and 2D-NMR and HR-ESI-MS data as well as comparison with the literature. Compounds (2) and (5) were isolated from Solanum melongena for the first time while compounds (3) and (4) were the first isolated from the Solanum genus. Besides, compounds 2-4 showed weak anti-inflammatory activities against NO production in RAW 264.7 macrophage line with IC50 values ranging from 54.28 to 91.37 μg/ml.
On the Mass Quantization of Black Holes

Black holes are relatively simple cosmic objects that are characterized by their mass, their angular momentum and their electric charge. However, the laws that govern them are laws that we do not yet fully know. We can only sketch what really happens inside or around them. This paper tries to discover some of its secrets such as its minimum size and the law of the quantification of its mass. Finally, the “myth” of the Planck mass is busted.
Algorithm for soft open points to solve thermal and voltage constraints in low-voltage distribution networks

Thermal and voltage constraints in the low voltage network (0.4 kV) may become more prevalent if increases in load or increases in distributed generation occur. Typically, constraints in the distribution network are solved by replacing the transformer, replacing the feeders, or installing a new substation. One solution to avoid these costly reinforcements is to utilise power electronics. The UK Power Networks project called Flexible Urban Networks – Low Voltage (FUN-LV) explored the use of connecting multiple feeders with power electronics. This paper reports on the design of the control algorithm and demonstrates the operation by presenting field trial results.
Impact of Current Technology in Laparoscopic Adrenalectomy: 20 Years of Experience in the Treatment of 254 Consecutive Clinical Cases

Background: Laparoscopic adrenalectomy (LA), which avoids large abdomen incisions, is considered the gold standard technique for the treatment of benign small- and medium-size adrenal masses (<6 cm) and weighing < 100 g. A trascurable mortality and morbidity rate, short hospitalization and patient rapid recovery are the main advantages compared to traditional surgery. During the past decade, a new surgical technology has been developed that expedites a “clipless” adrenalectomy. Here, the authors analyze a clinical series of 254 consecutive patients who were affected by adrenal gland neoplasms and underwent LA by the transabdominal lateral approach over the two last decades. A literature review is also presented. Methods: Preoperative, intraoperative and postoperative data from 254 patients who underwent LA between January 2003 and December 2022 were retrospectively collected and reviewed. Diagnosis was obtained on the basis of clinical examination, laboratory values and imaging techniques. Doxazosin was preoperatively administered in the case of pheochromocytoma (PCC) while spironolactone and potassium were employed to treat Conn’s disease. The same surgeon (CG) performed all the LA and utilized the same laparoscopic transabdominal lateral approach. Different dissection tools—ultrasonic, bipolar or mixed scissors—and hemostatic agents were used during this period. The following results were obtained: 254 patients were included in the study; functioning tumors were diagnosed in 155 patients, 52 patients were affected by PCCs, 55 by Conn’s disease, 48 by Cushing’s disease. Surgery mean operative time was 137.33 min (range 100–180 min) during the learning curve adrenalectomies and 98.5 min (range 70–180) in subsequent procedures. Mean blood loss was respectively 160.2 mL (range 60–280) and 96.98 mL (range 50–280) in the first 30 procedures and the subsequent ones. Only three conversions (1.18%) to open surgery occurred. No mortality or postoperative major complications were observed, while minor complications occurred in 19 patients (3.54%). In 153 out of 155 functioning neoplasms, LA was effective in the normalization of the endocrine profile. According to our experience, a learning curve consisting of 30 cases was identified. In fact, a lower operative time and a lower complication rate was reported following 30 LA. Conclusions: LA is a safe procedure, even for masses larger than 6 cm and PCCs. Undoubtedly, the development of surgical technology has made it possible reducing operative times, performing a “clipless” adrenalectomy and extending the indications in the treatment of more complex patients. A multidisciplinary team, in referral high-volume centers, is recommended in the management of adrenal pathology. A 30-procedure learning curve is necessary to improve surgical outcomes.
T-HSER: Transformer Network Enabling Heart Sound Envelope Signal Reconstruction Based on Low Sampling Rate Millimeter Wave Radar

The four stages (first heart sound (S1), systole, second heart sound (S2), and diastole) of heartbeat sounds recorded by contact seismocardiogram (SCG) reflect the health of the heart, but these stages are challenging to measure by noncontact millimeter wave radar. If the sampling rate of millimeter wave radar is increased, this will increase the amount of data storage needed for the long-term monitoring of human vital signs. This article presents an algorithm for reconstructing the envelope of high-frequency heart sound signals using low-frequency millimeter wave radar signals, as well as a heart sound envelope segmentation algorithm based on peak points. Its design principle is a combination of signal processing and a transformer network, which is called T-HSER. This technique maps the low-frequency radar signal into a high-frequency heart sound envelope signal through the transformer network and determines the four different stages of the heart sound using appropriate thresholds. Based on the training of more than 30000 heartbeats of 25 healthy subjects and the prediction evaluation of six subjects, the T-HSER algorithm is shown to reconstruct the high-frequency heart sound envelope signal with high correlation. Moreover, the mean correlation can reach 0.85 on one minute of data, which is higher than that of the bidirectional long short-term memory algorithm, and can effectively distinguish the four stages of the heart sound so that the mean absolute error (MAE) between the predicted value and the ground truth of S1 and S2 is within a tolerable range (70 ms). At the same time, the algorithm is suitable for low sampling rate radar, which greatly reduces the amount of data storage required.
Cricket Scotland Women’s Twenty-20 International Cricket Council World Cup Qualifier: A Pilot Prospective Cohort Injury Study

Background: Cricket is the world’s second most popular spectator sport with the Twenty-20 form emerging as one of the most popular match formats for male and female players. Little research has been conducted into the injury profile of Women’s Twenty-20 cricket. As a first step toward implementing injury reduction and prevention strategies, injury surveillance was conducted for Cricket Scotland during the Women’s Twenty-20 International Cricket Council World Cup Qualifier (held from 29th August-07th September 2019). Objectives: To describe the incidence, nature, anatomical location and mechanisms of new medical attention injuries sustained by Cricket Scotland Women’s Twenty-20 Team during the Women’s Twenty-20 International Cricket Council World Cup Qualifier in order to best inform appropriate stakeholders regarding future injury reduction and prevention strategies. Design: Prospective cohort study. Methods : Injury data was collected prospectively by the team physiotherapist during the period 28th August-07th September 2019 for Cricket Scotland Women’s Twenty-20 Team during the Women’s Twenty-20 International Cricket Council World Cup Qualifier
Hidden Sources of Anti-Muslim Attitudes: Joint Effects of Interactions and Exposure to Out-Groups

Abstract Interactions between social identity groups can reduce perceptions of threatening out-groups and improve inter-group attitudes. But these interactions have an inevitable side effect: while an interaction may improve attitudes among its participants, the same interaction can increase exposure to out-groups in the proximity of the interaction, leading to increased perceptions of threat among those not participating in the interaction. With such negative externalities in mind, this paper argues that the presence of a large number of out-group members both improves and aggravates native attitudes toward out-groups in the same area, which may, in the aggregate, conceal a hot spot of anti-immigration attitudes. This study examines the effects of interaction and exposure through a series of surveys of native attitudes toward Muslim immigrants in the Netherlands. While the exposure effect was not observed, empirical analyses suggest that brief interactions tend to worsen negative attitudes toward Muslims, possibly due to their physical and religious appearances. This highlights the importance of visual cues in shaping inter-group relations, as these visual cues may prompt natives to sort out interactions based on appearance, hindering efforts to promote inter-group contact between Muslims and non-Muslims.
Nivel de conocimiento sobre periimplantitis de los residentes de la especialidad de Periodoncia e Implantes de la Escuela Profesional de Estomatología de la Universidad Andina del Cusco

Antecedentes: El tratamiento con implantes dentales se ha incrementado rápidamente a nivel mundial, pero cabe resaltar que también han incrementado los casos con enfermedades periimplantarias, como la periimplantitis; por lo tanto, se debe valorar la importancia del conocimiento de estas enfermedades por parte de los especialistas en periodoncia e implantes, quienes en su práctica profesional evidenciarán esta patología, para que así puedan prevenir, diagnosticar y tratar la periimplantitis. Objetivo: Determinar el nivel de conocimiento sobre la periimplantitis de los residentes de la especialidad de Periodoncia e Implantes de la Escuela Profesional de Estomatología de la Universidad Andina del Cusco, durante el 2017. Material y métodos: El estudio fue aplicativo, cuantitativo, descriptivo y transversal; basado en la aplicación de un cuestionario validado en una muestra integrada por 50 estudiantes matriculados en la especialidad de Periodoncia e Implantes de la Escuela Profesional de Estomatología de la Universidad Andina del Cusco, durante el segundo semestre académico de 2017. Resultados: El 44 % de los residentes de la especialidad de Periodoncia e Implantes tiene un nivel medio de conocimiento sobre la periimplantitis; el 36 %, un nivel bajo; y el 20 %, un nivel alto. Conclusiones: Se determinó que los residentes encuestados de la especialidad de Periodoncia e Implantes de la Escuela Profesional de Estomatología de la Universidad Andina del Cusco tienen un nivel medio de conocimiento sobre la periimplantitis; de forma específica, se estableció que el nivel de conocimiento dependerá del año y semestre que cursen los residentes.
Eight-Day Fast and a Single Bout of Exercise: The Effect on Serum Methylarginines and Amino Acids in Men

Changes in serum concentration of methylarginines and amino acids after exercise are well documented, whereas the effects of exercise applied together with fasting are still debated and not thoroughly studied. Thus, we hypothesised that alterations in methylarginines such as ADMA, SDMA and L-NMMA might be responsible for decreased exercise performance after 8 days of fasting. Additionally, we propose that conditions in which the human body is exposed to prolonged fasting for more than a week elicit a distinctly different response to exercise than after overnight fasting. A group of 10 healthy men with previous fasting experience participated in the study. The exercise test was performed until exhaustion with a gradually increasing intensity before and after the 8-day fast. Blood samples were collected before and immediately after exercise. ADMA, SDMA, L-NMMA, dimethylamine and amino acids were analysed in serum samples by ID-LC-MS/MS. SDMA, L-NMMA and dimethylamine significantly decreased after 8 days of fasting, whereas ADMA did not change. BCAA, Phe, alanine and some other amino acids increased after fasting. Exercise-induced changes in amino acids were distinct after an 8-day fast compared to overnight fasting. A decrease in physical performance accompanied all of these alterations. In conclusion, our data indicate that neither methyl-arginine changes nor the Trp/BCAA ratio can explain exercise-induced fatigue after fasting. However, the observed decrease in hArg concentration suggests the limited synthesis of creatine, possibly contributing to reduced physical performance.
EMPREENDEDORISMO E A SUA IMPORTÂNCIA NO ATUAL CENÁRIO ECONÔMICO E SOCIAL

O presente artigo traz uma síntese do que tem sido publicado e estudado sobre empreendedorismo. O objetivo é oferecer referencial teórico básico a quem pretende entender melhor a importância do empreendedorismo no cenário atual. A proposta principal é apresentar as variáveis que geralmente passam despercebidas pelos líderes envolvidos no processo de busca de melhoria e inovação. Nos dias atuais, o empreendedorismo tem sido de grande importância para o desenvolvimento econômico e social. E a Administração e a ciência que oferecem ferramentas que possibilitam identificar a importância do empreendedorismo nestes cenários, além de possibilitar e ampliar estratégias para desenvolver uma sociedade mais empreendedora. O empreendedorismo tem uma cultura que deve ser difundida em todos os níveis organizacionais, estimulando a criatividade dos colaboradores por meio de remuneração com o intuito de mantê-los motivados, melhorando assim o clima organizacional e resultando no aumento de melhor desempenho. Deste modo, o artigo aborda uma pesquisa bibliográfica descritiva, que busca por meio de métodos, dados e informações, oferecer um melhor aprendizado sobre o assunto.
GESTALTS IN CAD-PLANS Analysis of a similarity concept

CAD plans in the domain of architecture contain thousands of design fragments (cases) which could be helpful for later use. In FABEU we try to find those fragments which are usable, to evaluate and adapt them to the actual problem. The presented paper reduces the notion of usefulness to one of similarity and describes a similarity criteria that is based on detection of "gestalts". Furthermore, it describes methods of how to confirm the usefulness of cases found using this criteria.
Improved adaptive fault‐tolerant control design for hypersonic vehicle based on interval type‐2 T‐S model

This study proposes an improved adaptive fault estimation and accommodation algorithm for a hypersonic flight vehicle that uses an interval type‐2 Takagi‐Sugeno fuzzy model and a quantum switching module. First, an interval type‐2 Takagi‐Sugeno fuzzy model for the hypersonic flight vehicle system with elevator faults is developed to process the nonlinearity and parameter uncertainties. An improved adaptive fault estimation algorithm is then constructed by adding an adjustable parameter. The quantum switching module is also applied to the estimation part to select an appropriate algorithm in different fault cases. The estimation results from the given fuzzy observer are used to design a type‐2 fuzzy fault accommodation controller to stabilize the fuzzy system. The stability of the proposed scheme is analyzed using the Lyapunov stability theory. Finally, the validity and availability of the method are verified by a series of comparisons on numerical simulation results.