Miracle-dz/UniFAR-FTUs huggingface dataset:
Rotor Flux Reference Generation Control Strategy for Direct Torque Controlled DFIG

The wind turbines based Doubly Fed Induction Generator (DFIG) is not able to support the voltage and the frequency of the grid during and immediately following the grid failure. This would cause major problems for the systems stability, but the turbines should stay connected to the grid in case of a failure. This can be achieved by using crowbar protection in particularly during voltage dips. When low depth voltage dips occur, the necessity of crowbar protection can be eliminated by using proposed Direct Torque Control (DTC), with a proper rotor flux generation strategy, by which during the fault it will be possible to maintain the machine connected to grid, generating power from the wind, reducing the stator and rotor over currents, eliminating the torque oscillations that nor- mally produce such voltage dips and fast dynamic response accompanies the overall control of the wind turbine. In this chapter, the DFIG performance is analyzed and the results are presented for with proposed control strategy with and without voltage dip, without control strategy with voltage dip, and control strategy during longer voltage dip.
c-yes AND bcl-2 GENES LOCATED ON 18q21.3 IN A FOLLICULAR LYMPHOMA

The c-yesl and bcl-2 genes have been independently mapped analysis showed the breakpoint to be at 14q32.3 and 18q21.3 at the same position of the chromosome band, 18q21.3, which [t(14;18) (q32.3;q21.3)] (Ohno et al., 1985). The FL-18EB is a breakpoint in the t(l4;la) chromosomal translocation. cell line, a derivative of FL-18, was established in vitro by High-molecular-weight genomic. DNAs and mRNA i! olated EBV infection. One half of the FL-18EB cells have a tetraploid
Elastic response of coating materials in thermoelasticity: Indented by a hot punch

Abstract The indentation problem of coating materials in thermoelasticity is investigated. Based on the Papkovitch–Neuber potential functions, general displacement and stress solutions of the coating layer and the substrate body are derived in thermoelasticity. Fourier transform and Bessel function are used to obtain the explicit elastic response. The influences of the layer thickness on the elastic response are studied. Also, three heated indenters are employed to study the indentation behavior involving heat flow. Besides, the influences of the temperature on the elastic response are distinguished. The results involving heat flow show significant effects on the contact behaviors.
Identification and Geometric Characterization of Lie Triple Screw Systems

It is known that the twist space of a (plunging) constant-velocity (CV) coupling with intersecting shafts consists, in all configurations, of a planar field of zero-pitch screws, namely Hunt's fourth special threesystem (with principal pitches (1; 0; 0)), hereafter denoted S_(3;4). The input and output shafts form a mirror symmetry about the system plane, hereafter referred to as the bisecting plane. The persistence of the twist space, i.e. the invariance of its principal and reciprocal principal pitches, is achieved by a parallel mechanism with prescribed connecting chains, with each one of them having mirror symmetric joint axes about the bisecting plane. Recently, the first author reported an important discovery, namely that S_(3;4), though not being a Lie subalgebra of the Lie algebra se(3) of the special Euclidean group SE(3), presents similar characteristics, which underlie the operation of a CV coupling. First, S_(3;4) is closed under two consecutive Lie bracket operations (or a Lie triple product), thus being referred to as a Lie triple system; second, taking the exponential of all twists in S_(3;4) generates a submanifold of SE (3), which is exactly the continuous-motion manifold of the coupling. In this paper, we first give a geometric characterization of the Lie product and the Lie triple product of a screw system. Then, we present a systematic identification of all Lie triple screw systems of se (3), by an approach based on both algebraic Lie group theory and descriptive screw theory.
Treatment of crow’s feet lines and forehead lines with Botox (onabotulinumtoxinA): Development, insights, and impact

Extrinsic and age-related intrinsic factors contribute to the development of facial lines, including lateral canthal lines (called crow’s feet lines [CFL]) and horizontal forehead lines (FHL). OnabotulinumtoxinA is a highly effective treatment for facial lines that inhibits acetylcholine release at the neuromuscular junction. This temporary chemical denervation leads to localized muscle relaxation and subsequent wrinkle reduction. Early studies of onabotulinumtoxinA treatment for facial neuronal disorders such as dystonia documented improvements in FHL and CFL. After the neurotoxin was approved for treating frown lines (glabellar lines [GL]), individuals requested treatment for other rhytids, and physicians continued assessing use in new areas. Once onabotulinumtoxinA was in clinical trial development, its efficacy and safety for CFL and FHL were successively evaluated as required by the US Food and Drug Administration and by key global health authorities, including those in the European Union, Japan, and China. Allergan, collaborating with leading physicians, established clinical programs that included novel safety and efficacy measures to meet regulatory requirements. Global, phase 3, randomized, controlled studies of CFL and FHL met rigorous primary endpoints. Some countries mandated clinical trial data beyond US and European regulations, and Allergan conducted 11 studies in total, fulfilling diverse regulatory and study population data requirements. Adverse events associated with local spread, including brow and eyelid ptosis, diplopia, headache, and eyelid sensory disorder, were infrequent and well tolerated. Consequently, onabotulinumtoxinA treatment of upper facial lines is now established globally as a highly effective, minimally invasive treatment for patients to achieve a natural appearance and look younger.
Treatment of glabellar lines with Botox (onabotulinumtoxinA): Development, insights, and impact

OnabotulinumtoxinA is an injectable medication that produces muscle relaxation through local chemical denervation at the neuromuscular junction. Discovery of onabotulinumtoxinA’s aesthetic benefits occurred serendipitously in the 1980s at the intersection of several medical disciplines, including ophthalmology, neurology, otolaryngology, and dermatology. Patients receiving onabotulinumtoxinA for blepharospasm, hemifacial spasm, and dystonia noticed their periorbital wrinkles disappearing, particularly frown lines between the eyebrows called glabellar lines (GL). Aesthetic use of onabotulinumtoxinA necessitated rigorous training programs and vigilant monitoring by Allergan. Approval for the GL indication was based on 2 similarly designed, double-blind, randomized, multicenter clinical studies. Subjects with moderate to severe GL receiving onabotulinumtoxinA achieved significantly greater improvement in GL severity than those receiving placebo. In subsequent studies, more than 80% of subjects were satisfied with onabotulinumtoxinA treatment through day 60, and many reported looking approximately 4 years younger at weeks 4 and 12 than at baseline. OnabotulinumtoxinA has a rapid onset of action, and peak effect occurs between 30 and 60 days. The median duration of response for dynamic GL in the initial studies was 120 days and response progressively improved with subsequent treatments. OnabotulinumtoxinA was well tolerated, and the 2 most common adverse events, headache and blepharoptosis, tended to decrease in frequency with repeat treatment. The novel use of onabotulinumtoxinA for treating GL was an important step in addressing the clinical need for a noninvasive, straightforward, office-based procedure for facial lines that also left patients extremely satisfied with its treatment effects and represented the beginning of its widespread use for numerous aesthetic indications.
18q21.1q21.32 Deletion in a Patient With Juvenile Cerebral Infarction

The chromosome 18q deletion syndrome is a well-recognized chromosomal aberration characterized by intellectual disability, facial dysmorphism, short stature, microcephaly, cardiac anomalies, such as atrial and ventricular septal defect, and hypotonia; however, the phenotype is highly variable depending on the combination of genes within the chromosomal aberration regions. Thus far, no association was found between 18q deletion and cerebral infarction. Herein, we report a case of 18q deletion syndrome that caused juvenile cerebral infarction. A 32-year-old woman with an intellectual disability and facial dysmorphism presented with sudden-onset left-sided weakness. Brain magnetic resonance imaging revealed a striatocapsular infarction. Abnormalities in thrombotic profiles and embolic sources could not be identified. Microarray-based comparative genomic hybridization analysis detected a microdeletion in chromosome 18 encompassing the cytoregion 18q21.1q21. 32. The deletion region contains the TCF4 and SMAD4 genes, whose haploinsufficiency causes the causative genes of Pitt-Hopkins syndrome (PTHS) and juvenile polyposis/hereditary hemorrhagic telangiectasia (JPHT or JPHHT), respectively. The patient’s facial features were characteristic of PTHS, including a broad, beaked nasal bridge and a wide mouth with a bow-shaped upper lip. On the contrary, the patient did not show breathing abnormalities, which is one of the hallmarks of PTHS. We could not elucidate the relationship between cerebral infarction and genes included in the deleted region of 18q. However, if patients with chromosomal aberrations have cerebral infarctions, investigating the genes included within the chromosomal aberration regions may increase our knowledge of the genes involved in juvenile cerebral infarction.
Adapted tissue assay for the assessment of ileal granulocyte degranulation following in ovo inoculation with select bacteria or coccidial challenge in chickens

A previously described heterophil degranulation assay was adapted for use with ileal mucosal tissue via quantification of β-D-glucuronidase and assay end product 4-methylumbelliferone (4-MU). Three initial experiments evaluated the effect of in ovo inoculations of Citrobacter freundii (CF) or mixed lactic acid bacteria (LAB) on ileal granulocyte degranulation. Inoculations were administered on embryonic d18, body weights (BW) were recorded on day of hatch (DOH) and d10 to calculate body weight gain (BWG), and ileal mucosal scrapings were collected on DOH or d10 for the 4-MU assay. In all experiments, treatments were statistically analyzed relative to control groups. Treatments minimally affected BWG in all in ovo experiments (p > 0.05) relative to respective control groups. Similarly, ileal degranulation in in ovo treatments did not statistically differ (p > 0.05). Based on BWG, in ovo treatments may have induced low-level inflammation unable to elicit detectable changes via the 4-MU assay. Four subsequent experiments were conducted to evaluate effects of Eimeria maxima (EM) on ileal degranulation. Treatments included non-inoculated controls and low, medium, or high EM infection. Across all four experiments, final BW or BWG over the inoculation period were suppressed (p < 0.05) in EM groups relative to respective controls with the exception of EM-low (p = 0.094) and EM-medium (p = 0.096) in one trial. Ileal mucosal scrapings for the 4-MU assay were collected on day of peak lesions. Resulting values were reduced (p < 0.05) for EM treated birds in three experiments with the exception of EM-medium (p = 0.247). No differences were observed in one experiment (p = 0.351), which may have been attributed to a variation in strain of infecting Eimeria. Although refinement for low level inflammation is warranted, results indicate successful adaptation of the 4-MU assay for use with intestinal tissue during significant gastrointestinal inflammation.
ABVENTURE-P pilot trial of physical therapy versus standard of care following ventral hernia repair: Protocol for a randomized controlled trial

Hernia disease is one of the most common reasons patients seek surgical treatment, yet nearly 1 in 4 patients seeking ventral hernia repair in the United States suffer from chronic pain, disability, and diminished physical activity. The relationships between the anterior abdominal wall, lower back, diaphragm, and pelvic floor are critical in providing function and quality of life, yet management of hernia disease has been limited to surgical restoration of anatomy without taking into consideration the functional relationships of the abdominal core. Therefore, the primary goal of this study is to evaluate the feasibility of implementing physical therapy targeted to improving stability and function in this population. A secondary goal is to estimate whether pre-operative abdominal core function predicts responsiveness to physical therapy. This study is a registry-based randomized controlled trial (NCT05142618: Pilot Trial of Abdominal Core Rehabilitation To Improve Outcomes After Ventral Hernia Repair (ABVENTURE-P)). All participants will be randomized to one of two post-operative treatment arms: standard of care plus up to 16 sessions of physical therapy, or standard of care alone. Primary timepoints include pre-operative (baseline) and ten weeks after surgery, with intermediate or secondary timepoints 30 days, 6 months, and 1 year post-operative. At each timepoint, participants will undergo functional and patient-reported outcome testing. We will also collect data on retention rate and treatment adherence. An intention to treat approach is planned for all analyses, using all participants who were randomized and have available data at the 10-week timepoint. This is a pilot and feasibility trial, hence our goals are to establish safety and initial efficacy of the PT intervention, retention and adherence to both PT and control arms, whether pre-operative abdominal core function predicts responsiveness to PT, and to collect a large enough sample to power a future definitive multi-center randomized controlled trial.
Regulation of the phagocytic activity of astrocytes by neuroimmune mediators endogenous to the central nervous system

The phagocytic activity of glial cells is essential for maintaining normal brain activity, and its dysfunction may contribute to the central nervous system (CNS) pathologies, including neurodegenerative diseases. Phagocytic activity is one of the well-established neuroimmune functions of microglia. Although emerging evidence indicates that astrocytes can also function as CNS phagocytes in humans and rodents, limited information is available about the molecular mechanism regulating this function. To address this knowledge gap, we studied modulation of the phagocytic activity of human U118 MG astrocytic cells and murine primary astrocytes by four CNS inflammatory mediators and bacterial endotoxin lipopolysaccharide (LPS). LPS and cytochrome c (CytC) upregulated, while interferon (IFN)-γ downregulated, phagocytosis of latex beads by human astrocytic cells and phagocytosis of synaptosomes by murine primary astrocytes. Interleukin (IL)-1β and tumor necrosis factor (TNF)-α had no effect on the phagocytic activity of human astrocytic cells but upregulated this function in murine astrocytes. Varying effects of combinations of the above inflammatory mediators were observed in these two cell types. LPS- and CytC-induced phagocytic activity of human astrocytic cells was partially mediated by activation of toll-like receptor 4 (TLR4). By monitoring other functions of astrocytes, we concluded there were no correlations between the effects of the mediators studied on astrocyte phagocytic activity and their secretion of cytokines, cytotoxins, or glutamate. Our study identified four candidate CNS regulators of astrocyte phagocytic activity. Future investigation of molecular mechanisms behind this regulation could identify novel therapeutic targets allowing modulation of this astrocyte-mediated clearance mechanism in CNS pathologies.
STAR-FC: Structure-Aware Face Clustering on Ultra-Large-Scale Graphs

Face clustering is a promising method for annotating unlabeled face images. Recent supervised approaches have boosted the face clustering accuracy greatly, however their performance is still far from satisfactory. These methods can be roughly divided into global-based and local-based ones. Global-based methods suffer from the limitation of training data scale, while local-based ones are inefficient for inference due to the use of numerous overlapped subgraphs. Previous approaches fail to tackle these two challenges simultaneously. To address the dilemma of large-scale training and efficient inference, we propose the STructure-AwaRe Face Clustering (STAR-FC) method. Specifically, we design a structure-preserving subgraph sampling strategy to explore the power of large-scale training data, which can increase the training data scale from <inline-formula><tex-math notation="LaTeX">${10^{5}}$</tex-math><alternatives><mml:math><mml:msup><mml:mn>10</mml:mn><mml:mn>5</mml:mn></mml:msup></mml:math><inline-graphic xlink:href="lu-ieq1-3299263.gif"/></alternatives></inline-formula> to <inline-formula><tex-math notation="LaTeX">${10^{7}}$</tex-math><alternatives><mml:math><mml:msup><mml:mn>10</mml:mn><mml:mn>7</mml:mn></mml:msup></mml:math><inline-graphic xlink:href="lu-ieq2-3299263.gif"/></alternatives></inline-formula>. On this basis, a novel hierarchical GCN training paradigm is further proposed for better capturing the dynamic local structure. During inference, the STAR-FC performs efficient full-graph clustering with two steps: graph parsing and graph refinement. And the concept of node intimacy is introduced in the second step to mine the local structural information, where a calibration module is further proposed for fairer edge scores. The STAR-FC gets 93.21 pairwise F-score on standard partial MS1M within 312 seconds, which far surpasses the state-of-the-arts while maintaining high inference efficiency. Furthermore, we are the first to train on an ultra-large-scale graph with 20 M nodes, and achieve superior inference results on 12 M testing data. Overall, as a simple and effective method, the proposed STAR-FC provides a strong baseline for large-scale face clustering.
Synthesis of InSb nanowire architectures : building blocks for Majorana devices

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Parameter estimation for complex thermal-fluid flows using approximate Bayesian computation

9 Approximate Bayesian computation (ABC) is a data-driven technique that uses many low-cost numerical 10 simulations to estimate unknown physical or model parameters (e.g., boundary conditions and material 11 properties), as well as their uncertainties, given reference data from real-world experiments or higher-fidelity 12 numerical simulations. In this study, ABC is used to estimate unknown parameters in complex thermal-fluid 13 flows, and the technique is demonstrated on a periodically forced high-temperature jet and a steadily forced 14 helium-air plume. In the first case, computational reference data are used to assess the accuracy of ABC 15 when estimating the frequency, amplitude, and mean of the periodic velocity forcing at the jet inlet. These 16 tests show that ABC provides accurate and reasonably certain estimates of inflow parameters even when 17 the model simulations imperfectly represent the physics underlying the reference data. These tests also 18 show that measurements far from the inlet can be used to perform the estimation, and that temperature 19 measurements can be used to infer velocity inflow parameters. For the second case, ABC is used to estimate 20 the inlet Richardson number and its uncertainty given experimental measurements of the Strouhal number 21 within the plume. Once again, the approach is able to accurately estimate unknown parameters with 22 relatively low uncertainty. As a result, ABC is shown to be a versatile technique for estimating unknown 23 physical parameters when knowledge of a real-world system is limited or incomplete. 24
UBQLN2 and HSP70 participate in Parkin‐mediated mitophagy by facilitating outer mitochondrial membrane rupture

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two aging‐related neurodegenerative diseases that share common key features, including aggregation of pathogenic proteins, dysfunction of mitochondria, and impairment of autophagy. Mutations in ubiquilin 2 (UBQLN2), a shuttle protein in the ubiquitin‐proteasome system (UPS), can cause ALS/FTD, but the mechanism underlying UBQLN2‐mediated pathogenesis is still uncertain. Recent studies indicate that mitophagy, a selective form of autophagy which is crucial for mitochondrial quality control, is tightly associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and ALS. In this study, we show that after Parkin‐dependent ubiquitination of damaged mitochondria, UBQLN2 is recruited to poly‐ubiquitinated mitochondria through the UBA domain. UBQLN2 cooperates with the chaperone HSP70 to promote UPS‐driven degradation of outer mitochondrial membrane (OMM) proteins. The resulting rupture of the OMM triggers the autophagosomal recognition of the inner mitochondrial membrane receptor PHB2. UBQLN2 is required for Parkin‐mediated mitophagy and neuronal survival upon mitochondrial damage, and the ALS/FTD pathogenic mutations in UBQLN2 impair mitophagy in primary cultured neurons. Taken together, our findings link dysfunctional mitophagy to UBQLN2‐mediated neurodegeneration.