Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Age and Femoral Tunnel Drilling Technique on the Prevalence of Intra-articular Pathology at Both Primary and Revision ACL Reconstruction

Background: Studies have shown that meniscal and chondral lesions are more common at the time of revision anterior cruciate ligament reconstruction (ACLR) compared with primary surgery; however, few have evaluated the same patients through both primary and revision surgery. Purpose: To describe the prevalence of meniscal and chondral lesions at the time of primary and subsequent revision ACLR and to determine the effect of age and femoral tunnel drilling technique on the development of intra-articular pathology over time. Study Design: Case series; Level of evidence, 4. Methods: All patients who had primary and subsequent revision ACLR in the same knee between 1997 and 2022 were identified from a prospectively collated database. The grading of chondral surfaces in each compartment, the presence of any meniscal tears, and treatment performed were recorded. Patients were grouped according to age and femoral tunnel drilling technique to allow subgroup analysis. Results: Overall, 262 patients were included. Median age at primary surgery was 20.2 years. Lateral meniscal tears were more prevalent than medial tears at both primary (34.7% vs 28.2%; P = .11) and revision surgery (44.3% vs 40.8%; P = .43). Chondral lesions were most frequently found on the patella (8.8%) and the medial femoral condyle (MFC; 8.0%) at primary surgery. Between surgeries, new lesions developed most commonly on the MFC (13.0%) and the lateral femoral condyle (LFC; 11.1%). It was significantly more common for lateral meniscal tears treated with repair or left in situ at primary surgery to be healed at the time of revision surgery than medial tears (P = .01). Significantly more patients who had transtibial drilling of the femoral tunnel had a new meniscal tear at revision surgery (P = .001). Age did not have a significant influence on the prevalence of meniscal pathology. Conclusion: The prevalence of intra-articular pathology increased between primary and revision ACLR. Lateral meniscal tears were more prevalent than medial tears at both surgeries. At revision surgery, new chondral lesions were more commonly found on the MFC than the LFC. The higher incidence of new meniscal tears observed in the transtibial group may reflect the more vertical graft orientation with this technique and its inferior ability to control rotation.
Data Missingness Reporting and Use of Methods to Address It in Critical Care Cohort Studies

IMPORTANCE: Failure to recognize and address data missingness in cohort studies may lead to biased results. Although Strengthening the Reporting of Observational Studies in Epidemiology reporting guidelines advocate data missingness reporting, the degree to which missingness is reported and addressed in the critical care literature remains unclear. OBJECTIVES: To review published ICU cohort studies to characterize data missingness reporting and the use of methods to address it. DESIGN, SETTING, AND PARTICIPANTS: We searched the 2022 table of contents of 29 critical care/critical care subspecialty journals having a 2021 impact factor greater than or equal to 3 to identify published prospective clinical or retrospective database cohort studies enrolling greater than or equal to 100 patients. MAIN OUTCOMES AND MEASURES: In duplicate, two trained researchers conducted a manuscript/supplemental material PDF word search for “missing*” and extracted study type, patient age, ICU type, sample size, missingness reporting, and the use of methods to address it. RESULTS: A total of 656 studies were reviewed. Of the 334 of 656 (50.9%) studies mentioning missingness, missingness was reported for greater than or equal to 1 variable in 234 (70.1%) and it exceeded 5% for at least one variable in 160 (47.9%). Among the 334 studies mentioning missingness, 88 (26.3%) used exclusion criteria, 36 (10.8%) used complete-case analysis, and 164 (49.1%) used a formal method to avoid missingness. In these 164 studies, imputation only was used in 100 (61.0%), an analytic strategy only in 24 (14.6%), and both in 40 (24.4%). Only missingness greater than 5% (in ≥ 1 variable) was independently associated with greater use of a missingness method (adjusted odds ratio 2.91; 95% CI, 1.85–4.60). Among 140 studies using imputation, multiple imputation was used in 87 studies (62.1%) and simple imputation in 49 studies (35.0%). For the 64 studies using an analytic method, 12 studies (18.8%) assigned missingness as an unknown category, whereas sensitivity analysis was used in 47 studies (73.4%). CONCLUSIONS AND RELEVANCE: Among published critical care cohort studies, only half mentioned result missingness, one-third reported actual missingness and only one-quarter used a method to manage missingness. Educational strategies to promote missingness reporting and resolution methods are required.
A rare presentation of vanishing bile duct syndrome in Hodgkin lymphoma: Case report

In this report, we present the case of vanishing bile duct syndrome in the setting of classical Hodgkin lymphoma. Vanishing bile duct syndrome was diagnosed retrospectively in this patient with Hodgkin lymphoma, who initially presented with a hepatic abnormality presumed to be drug induced. Vanishing bile duct syndrome is characterized by the disappearance of bile ducts, with the progressive damage resulting in cholestasis. Thus, nivolumab therapy was initiated for Hodgkin lymphoma, in place of the standard ABVD (Doxorubicin, bleomycin, vinblastine, dacarbazine) regimen, which resulted in autoimmune hemolytic anemia. Alternatively, GDP (gemcitabine, dexamethasone, and carboplatin) chemotherapy with protocol modification resulted in better tolerance and remission of Hodgkin lymphoma. Granulocyte colony-stimulating factor support and romiplostim supplement were provided to prevent chemotherapy-induced neutropenia and thrombocytopenia, respectively. Due to the deranged liver function in our case, we initially suspected the etiology as drug-induced cholestatic injury. While hepatic failure is the leading cause of mortality among patients with Hodgkin lymphoma-related vanishing bile duct syndrome, our case report suggests a complete remission of vanishing bile duct syndrome following an adequate treatment of Hodgkin lymphoma and an improvement in the hepatic function. To conclude, our report describes the rare case of vanishing bile duct syndrome which heralded the diagnosis of Hodgkin lymphoma, and the effective management of Hodgkin lymphoma which precedes the improvement of hepatic abnormality.
Interictal magnetoencephalography abnormalities to guide intracranial electrode implantation and predict surgical outcome

Abstract Intracranial EEG is the gold standard technique for epileptogenic zone localization but requires a preconceived hypothesis of the location of the epileptogenic tissue. This placement is guided by qualitative interpretations of seizure semiology, MRI, EEG and other imaging modalities, such as magnetoencephalography. Quantitative abnormality mapping using magnetoencephalography has recently been shown to have potential clinical value. We hypothesized that if quantifiable magnetoencephalography abnormalities were sampled by intracranial EEG, then patients’ post-resection seizure outcome may be better. Thirty-two individuals with refractory neocortical epilepsy underwent magnetoencephalography and subsequent intracranial EEG recordings as part of presurgical evaluation. Eyes-closed resting-state interictal magnetoencephalography band power abnormality maps were derived from 70 healthy controls as a normative baseline. Magnetoencephalography abnormality maps were compared to intracranial EEG electrode implantation, with the spatial overlap of intracranial EEG electrode placement and cerebral magnetoencephalography abnormalities recorded. Finally, we assessed if the implantation of electrodes in abnormal tissue and subsequent resection of the strongest abnormalities determined by magnetoencephalography and intracranial EEG corresponded to surgical success. We used the area under the receiver operating characteristic curve as a measure of effect size. Intracranial electrodes were implanted in brain tissue with the most abnormal magnetoencephalography findings—in individuals that were seizure-free postoperatively (T = 3.9, P = 0.001) but not in those who did not become seizure-free. The overlap between magnetoencephalography abnormalities and electrode placement distinguished surgical outcome groups moderately well (area under the receiver operating characteristic curve = 0.68). In isolation, the resection of the strongest abnormalities as defined by magnetoencephalography and intracranial EEG separated surgical outcome groups well, area under the receiver operating characteristic curve = 0.71 and area under the receiver operating characteristic curve = 0.74, respectively. A model incorporating all three features separated surgical outcome groups best (area under the receiver operating characteristic curve = 0.80). Intracranial EEG is a key tool to delineate the epileptogenic zone and help render individuals seizure-free postoperatively. We showed that data-driven abnormality maps derived from resting-state magnetoencephalography recordings demonstrate clinical value and may help guide electrode placement in individuals with neocortical epilepsy. Additionally, our predictive model of postoperative seizure freedom, which leverages both magnetoencephalography and intracranial EEG recordings, could aid patient counselling of expected outcome.
Cutaneous drug reaction secondary to antitubercular regimen: A case report from Nepal

Cutaneous adverse drug reactions are known side effects of first-line antitubercular therapy, which ranges from mild pruritus to life-threatening toxic epidermal necrolysis. Severe cutaneous adverse drug reactions can lead to antitubercular therapy discontinuation and further complicates tuberculosis treatment. Here we present the case of a 49-year-old obese male who developed a generalized maculopapular rash within 24 hours of initiation of therapy followed by bullae over palms in 3 days. Antitubercular therapy was immediately discontinued, and he was managed with antihistamines, intravenous fluid, and electrolyte supplementation. He was discharged on antihistamines, a short course of systemic steroids, moxifloxacin, and bedaquiline (second-line antitubercular therapy (ATT)). Proper guidelines about rechallenge therapy will enormously aid in managing cutaneous adverse drug reactions, and efficient treatment of tuberculosis in these patients, and ceasing its progression to multisystemic complications. This article aims to discuss the presentation and management of cutaneous adverse drug reactions in the setting of Nepal.
The Effects of the UK Pregnancies Better Eating and Activity Trial Intervention on Dietary Patterns in Obese Pregnant Women Participating in a Pilot Randomized Controlled Trial

Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections.
The many roles of cyclic di-AMP to control the physiology of Bacillus subtilis

Abstract The dinucleotide cyclic di-AMP (c-di-AMP) is synthesized as a second messenger in the Gram-positive model bacterium Bacillus subtilis as well as in many bacteria and archaea. Bacillus subtilis possesses three diadenylate cyclases and two phosphodiesterases that synthesize and degrade the molecule, respectively. Among the second messengers, c-di-AMP is unique since it is essential for B. subtilis on the one hand but toxic upon accumulation on the other. This role as an “essential poison” is related to the function of c-di-AMP in the control of potassium homeostasis. C-di-AMP inhibits the expression and activity of potassium uptake systems by binding to riboswitches and transporters and activates the activity of potassium exporters. In this way, c-di-AMP allows the adjustment of uptake and export systems to achieve a balanced intracellular potassium concentration. C-di-AMP also binds to two dedicated signal transduction proteins, DarA and DarB. Both proteins seem to interact with other proteins in their apo state, i.e. in the absence of c-di-AMP. For DarB, the (p)ppGpp synthetase/hydrolase Rel and the pyruvate carboxylase PycA have been identified as targets. The interactions trigger the synthesis of the alarmone (p)ppGpp and of the acceptor molecule for the citric acid cycle, oxaloacetate, respectively. In the absence of c-di-AMP, many amino acids inhibit the growth of B. subtilis. This feature can be used to identify novel players in amino acid homeostasis. In this review, we discuss the different functions of c-di-AMP and their physiological relevance.
Electronic Supplementary Material: Evolutionary 1 dynamics of complex multiple games

In matrix A.1, we write the elements in the form ai,α, where i is the strategy of the focal 10 player. Using multiindex notation, α, is a vector written as α = (α1, α2), together representing 11 the group composition. The average payoffs of the two strategies are given by f1 = a1,(1,0)x1+ 12 a1,(0,1)x2 and f2 = a2,(1,0)x1 + a2,(0,1)x2. The replicator equation Eq. (A.2) [1, 2] describes the 13 change in frequency xi of strategy i over time. 14
Analogue Gravity

Analogue gravity is a research programme which investigates analogues of general relativistic gravitational fields within other physical systems, typically but not exclusively condensed matter systems, with the aim of gaining new insights into their corresponding problems. Analogue models of (and for) gravity have a long and distinguished history dating back to the earliest years of general relativity. In this review article we will discuss the history, aims, results, and future prospects for the various analogue models. We start the discussion by presenting a particularly simple example of an analogue model, before exploring the rich history and complex tapestry of models discussed in the literature. The last decade in particular has seen a remarkable and sustained development of analogue gravity ideas, leading to some hundreds of published articles, a workshop, two books, and this review article. Future prospects for the analogue gravity programme also look promising, both on the experimental front (where technology is rapidly advancing) and on the theoretical front (where variants of analogue models can be used as a springboard for radical attacks on the problem of quantum gravity).
nab-Paclitaxel for the treatment of pancreatic cancer

Background Nanoparticle albumin-bound paclitaxel (nab-P) plus gemcitabine (Gem) became a standard treatment option for metastatic pancreatic cancer (MPC) following positive results from a global phase III trial (MPACT). A large number of studies have now published results on the use of nab-P/Gem to treat advanced and early-stage disease, warranting a comprehensive review. The main goal of this systematic review is to summarize the efficacy and safety data of nab-P/Gem for the treatment of pancreatic cancer (PC). Methods This systematic review includes results from studies that either published results in a peer-reviewed journal or presented the results at a major oncology conference. Results Sixty-two studies were included (50 in the advanced/metastatic setting and 12 in the locally advanced setting). Most studies on the treatment of MPC were exclusively first line (33/50). Nevertheless, the studies in this review comprised a broad spectrum of patients, including those <65 and ≥65 years of age and those with a Karnofsky performance status of 70–100. Median overall survival (OS) in studies of nab-P/Gem in the advanced/metastatic setting ranged from 8.7 to 13.5 months. In addition, 15 studies of patients with advanced/metastatic PC examined nab-P/Gem as a backbone on which to add a variety of agents, including cancer stem cell inhibitors, stromal disrupting agents, and immune-modulating agents (median OS, 6.9–17 months). Ongoing trials are investigating nab-P/Gem with or without other agents across disease settings. Discussion Studies conducted after MPACT have demonstrated that nab-P/Gem is an effective regimen for the first-line treatment of MPC for a wide range of patients. Regimens using nab-P/Gem as a backbone on which to combine additional agents are being studied actively, particularly in the advanced disease setting. Ongoing studies will yield valuable insights on the utility of nab-P–containing regimens to improve patient outcomes in PC in both earlier-stage and advanced disease.
The Correlation between Residential Density and Greenhouse Gas Emissions in Surabaya City

Population growth is happening in cities, including Surabaya as the second largest metropolitan region in Indonesia. The population growth has an impact to the residential density, whereas residential is usually the largest part of land use in urban areas. In urabaya, residential use covers more than 60% of the total area. The intensive use of residential area has impacts on the environment. One significant issue is the consumption of energy that produces greenhouse gas emissions. This study is aimed at explaining the relationships between residential density and greenhouse gas emissions in Surabaya City, Indonesia. The residential density will be divided into three categories, i.e. low, medium and high density. The category of density is taken from the Identification Report of Surabaya Spatial Plan. The results of this study indicate that there are significant differences in the electrical energy consumption for the household sector in each residential density. These differences are mainly influenced by variables such as car ownership, ventilation system, the use of electrical power, cooking fuel and the way to use the home appliances. The highest total energy consumption per month exists in high density type. Although the average smallest energy consumption per household exists in medium density, the total energy consumption in medium density is much greater than that in the low density because the number of households in medium density is greater. The final result shows that the correlation between the total production of GHG emissions (CO2) and density has a direct or positive relationship, which means that the greater the density, the higher the production rate of GHG emissions (CO2).
Automated Search for Logistic Knowledge Tracing Models

This paper presents a tool for creating student models in logistic regression. Creating student models has typically been done by expert selection of the appropriate terms, beginning with models as simple as IRT or AFM but more recently with highly complex models like BestLR. While alternative methods exist to select the appropriate predictors for the regression-based models (e.g., step-wise selection or LASSO), we are unaware of their application to student modeling. Such automatic methods of model creation offer the possibility of better student models with either reduced complexity or better fit, in addition to relieving experts from the burden of searching for better models by hand with possible human error. Our new functions are now part of the preexisting R package LKT. We explain our search methods with two datasets demonstrating the advantages of using the tool with stepwise regression and regularization (LASSO) methods to aid in feature selection. For the stepwise method using BIC, the models are simpler (due to the BIC penalty for parameters) than alternatives like BestLR with little lack of fit. For the LASSO method, the models can be made simpler due to the fitting procedure involving a regularization parameter that penalizes large absolute coefficient values. However, LASSO also offers the possibility of highly complex models with exceptional fit.
CAJMS The First Diagnosed Case of Steroid-induced Kaposi's Sarcoma in Mongolia

Objectives: Kaposi's sarcoma (KS) is a vascular neoplasm with four main types. We report the first diagnosed case of steroid-induced KS in a non-HIV patient in Mongolia. Methods: A 57-year-old man presented hemorrhagic spots on his body after seven months of corticosteroid therapy due to the glomerulonephritis. Upon examination, the morphology, histopathology and immunohistochemistry indicated human herpes virus-8 (HHV-8) positive KS. Results: After the dose reduction of corticosteroids the lesions remarkably diminished in size and almost resolved as observed at the six-month follow-up. Conclusion: Medical professionals should be aware of the appearance of KS in patients receiving immunosuppressive therapies.
A Framework for Automated Generation of Questions Across Formal Domains

In this work, questions are tasks posed to secondary students to help them understand a subject, or to help educators assess their level of competency in it. Automated question generation is important today as content providers in education try to scale their eﬀorts. In particular, MOOCs need a continuous supply of new questions in order to oﬀer educational content to thousands of students, and to provide a fair assessment process. This paper innovates in three ways; (1) we describe question generation across domains, and, previous eﬀorts as instances of a general framework; (2) we establish ﬁrst-order logic as a suitable formal tool to describe question scenarios, questions and answers; and (3) we generalize a published question generation method based on logic programming and theorem proving to work across domains. We apply this approach to three domains in high school education—geometry, algebra and mechanics (physics)—and report initial results.
International Journal of Life science and Pharma Research Analysis of Phytoconstituents and Antimicrobial Properties of Bacopa monnieri (L.) Against Clinical Pathogen

: There are numerous therapeutic uses for medicinal plants in treating and managing numerous diseases. Traditional medicinal plants were mostly needed in the current scenario. The world's warmer and wetlands regions are home to the medicinal herb Bacopa monnieri (L.). It has been utilized for ages in Ayurvedic systems. The Bacopa monnieri was one of the traditional medicinal plants. These are commonly called "Brahmi," and the Tamil vernacular name is "Neerbrahmmi. " It is easy to cultivate and grow in all seasons. These peculiar active ingredients, also known as memory enhancement and phytoconstituents were enriched in this medicinal plant. The present study focused on analyzing phytoconstituents and the antimicrobial activity of Bacopa monnieri leaves. The efficacy of phytoconstituents on the antimicrobial activities concerning minimum inhibitory concentrations was performed with different polar and non-polar solvents of the respective plant. The phytoconstituents such as alkaloids, amino acids, coumarins, flavonoids, glycosides, phenols, phlobatannins, quinones, reducing sugars, saponins, steroids, tannins, and terpenoids were recorded, respectively. Antibacterial activity performed with following human clinical bacteria like Clostridium butyricum, Escherichia coli, Staphylococcus aureus, and Streptococcus pneumoniae, and the antifungal activity against human clinical such as Aspergillus flavus, A.niger, Aspergillus sp. , and Penicillium sp. were determined. Among the two solvent extractions, the aqueous extract showed a more significant result than the benzene extract. According to the MIC, the antimicrobial properties of B.monnieri with different extracts were analyzed. The very minimum concentration has shown better inhibitions against microbes. The present study explored the antimicrobial properties of human clinical pathogens. So, the B.monnieri aqueous extract of leaves was suggested for the treatment of microbial infections.