Miracle-dz/UniFAR-FTUs huggingface dataset:
The Earthscan reader in sustainable agriculture

Part 1: Agrarian and Rural Perspectives * The Post-War Task * Thinking Like a Mountain * The Unsettling of America * Ecological Literacy * An Amish Perspective * Becoming Native to this Place * Creating Social Capital * Part 2: Agroecological Perspectives * Reality Cheques* The External Costs of Agricultural Production in the United States* From Pesticides to People: Improving Ecosystem Health in the Northern Andes * Agroecology and Agroecosystems * The Doubly Green Revolution * Part 3: Social Perspectives * Reversals, Institutions and Change * The Hawkesbury Experience: Tales from a Road Less Travelled * Social Capital and the Collective Management of Resources * Gateway to the Global Garden: Beta/Gamma Science for Dealing with Ecological Rationality * Ecological Basis for Low-toxicity Integrated Pest Management (IPM) in Rice * Part 4: Perspectives from Industrialized Countries * Landscapes Lost and Found * The Farm as Natural Habitat * Diet and Health: Diseases and Food * Coming in to the Foodshed * Part 5: Perspectives from Developing Countries * Rethinking Agriculture For New Opportunities * Soil Recuperation in Central America: How Innovation was Sustained after Project Intervention * Sustainable Rural Life and Agroecology, Santa Catarina State, Brazil * Lessons of Cuban Resistance * Benefits from Agroforestry in Africa, with Examples from Kenya and Zambia * Reducing Food Poverty by Increasing Agricultural Sustainability in Developing Countries *
Strategic assessment of the risk posed to marine mammals by the use of airguns in the Antarctic Treaty area

This publication item contains 4 PDF documents: the risk assessment (RA) proper as submitted to ATCM / CEP in 2009 and three comprehensive reviews by international experts within the field of marine mammals and noise. The latter were commissioned by the AWI in 2011 and address both the RA and an evaluation of the RA by the Federal Environment Agency (UBA), the German Competent Authority for implementing the Protocol on Environmental Protection to the Antarctic Treaty. The UBA evaluation is available at http://www.umweltbundesamt. de/antarktis-e/archiv/evaluation_airguns_antarctic. pdf .
Understanding the link between pain invalidation and depressive symptoms: The role of shame and social support in people with chronic pain

Pain invalidation (e.g., having pain discounted) is a risk factor for depression among people with chronic pain, but the mechanisms remain unclear. Shame is a common, yet understudied, aspect of the pain experience. This study investigated whether pain-related shame helps explain the relationship between pain discounting and heightened depressive symptoms. The secondary aim was to examine whether social support can protect against the harmful effects of discounting. Patients with chronic pain (N = 305) were recruited from outpatient pain clinics. Participants completed an online cross-sectional survey and data were analyzed using moderated mediation analysis. Greater discounting was associated with greater depressive symptoms, and pain-related shame significantly mediated this relationship. Perceived social support attenuated the relationship between discounting and depressive symptoms. Greater attention towards pain-related shame as a treatment target is needed. Individual- and system-level interventions are required to address pain invalidation and bolster support for this population.
One‐year outcomes of deep brain stimulation in refractory Tourette syndrome

Deep brain stimulation (DBS) is one option for treating refractory Tourette syndrome (TS); however, it remains unclear which preoperative factors are predictive of DBS outcomes. This study investigated the efficacy of DBS targeting the anteromedial globus pallidus internus and evaluated predisposing factors affecting the outcomes of DBS in a single center in Korea.
Molecular Carcinogenesis

Correspondence Dr. Song Zhao, Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Erqi District, 450052 Zhengzhou, Henan Province, China. Email: drzsong@163.com Abstract Long noncoding RNAs (lncRNAs) have been implicated in the biology of esophageal cancer via mRNA degradation or translational inhibition. CDH3 is also aberrantly expressed in numerous cancers. This study was conducted with the hypothesis that ADAMTS9‐AS2 or CDH3 methylation plays a role in esophageal cancer cell activity and in vivo development. Firstly, mRNA levels of ADAMTS9‐AS2 and CDH3 in esophageal cancer tissues and cells were detected by reverse‐transcription quantitative polymerase chain reaction. Afterward, esophageal cancer OE21 cells were treated with overexpression of ADAMTS9‐AS2, siRNA against ADAMTS9‐AS2, overexpression of CDH3 and demethylating agent 5‐aza‐dc. The biological functions of esophageal cancer OE21 cells were assayed to define the regulatory mechanisms of ADAMTS9‐AS2 in esophageal cancer. The interactions among ADAMTS9‐ AS2, DNMT1/DNMT3 (A/B) and CDH3 were detected by MSP, RNA pull‐down, RIP, and ChIP assays. The in vitro findings were reproduced in nude mice to explore the role of ADAMTS9‐AS2 in the development of esophageal cancer in vivo. Esophageal cancers expressed low levels of ADAMTS9‐AS2 and high levels of CDH3. Methylation of CDH3 promoter was induced by ADAMTS9‐AS2 via DNMT1/DNMT3 (A/B). Furthermore, proliferation, invasion, and migration of esophageal cancer cells were inhibited by ADAMTS9‐AS2 via downregulation of CDH3. Suppressed esophageal cancer development in vivo was also detected after ADAMTS9‐AS2 overexpression. Overexpressed ADAMTS9‐AS2 aids in the suppression of esophageal cancer development, which is achieved via inducing CDH3 promoter methylation.
Ambient Temperature Effects on the Spring and Autumn Somatic Growth Trajectory Show Plasticity in the Photoneuroendocrine Response Pathway in the Tundra Vole

Seasonal mammals register photoperiodic changes through the photoneuroendocrine system enabling them to time seasonal changes in growth, metabolism, and reproduction. To a varying extent, proximate environmental factors like ambient temperature (Ta) modulate timing of seasonal changes in physiology, conferring adaptive flexibility. While the molecular photoneuroendocrine pathway governing the seasonal responses is well defined, the mechanistic integration of nonphotoperiodic modulatory cues is poorly understood. Here, we explored the interaction between Ta and photoperiod in tundra voles, Microtus oeconomus, a boreal species in which the main impact of photoperiod is on postnatal somatic growth. We demonstrate that postweaning growth potential depends on both gestational and postweaning patterns of photoperiodic exposure, with the highest growth potential seen in voles experiencing short (8 h) gestational and long (16 h) postweaning photoperiods—corresponding to a spring growth program. Modulation by Ta was asymmetric: low Ta (10 °C) enhanced the growth potential of voles gestated on short photoperiods independent of postweaning photoperiod exposure, whereas in voles gestated on long photoperiods, showing a lower autumn-programmed growth potential, the effect of Ta was highly dependent on postweaning photoperiod. Analysis of the primary molecular elements involved in the expression of a neuroendocrine response to photoperiod, thyrotropin beta subunit (tshβ) in the pars tuberalis, somatostatin (srif) in the arcuate nucleus, and type 2/3 deiodinase (dio2/dio3) in the mediobasal hypothalamus identified dio2 as the most Ta-sensitive gene across the study, showing increased expression at higher Ta, while higher Ta reduced somatostatin expression. Contrastingly dio3 and tshβ were largely insensitive to Ta. Overall, these observations reveal a complex interplay between Ta and photoperiodic control of postnatal growth in M. oeconomus, and suggest that integration of Ta into the control of growth occurs downstream of the primary photoperiodic response cascade revealing potential adaptivity of small herbivores facing rising temperatures at high latitudes.
Improved protein structure prediction with trRosettaX2, AlphaFold2, and optimized MSAs in CASP15

We present the monomer and multimer structure prediction results of our methods in CASP15. We first designed an elaborate pipeline that leverages complementary sequence databases and advanced database searching algorithms to generate high‐quality multiple sequence alignments (MSAs). Top MSAs were then selected for the subsequent step of structure prediction. We utilized trRosettaX2 and AlphaFold2 for monomer structure prediction (group name Yang‐Server), and AlphaFold‐Multimer for multimer structure prediction (group name Yang‐Multimer). Yang‐Server and Yang‐Multimer are ranked at the top and the fourth, respectively, for monomer and multimer structure prediction. For 94 monomers, the average TM‐score of the predicted structure models by Yang‐Server is 0.876, compared to 0.798 by the default AlphaFold2 (i.e., the group NBIS‐AF2‐standard). For 42 multimers, the average DockQ score of the predicted structure models by Yang‐Multimer is 0.464, compared to 0.389 by the default AlphaFold‐Multimer (i.e., the group NBIS‐AF2‐multimer). Detailed analysis of the results shows that several factors contribute to the improvement, including improved MSAs, iterated modeling for large targets, interplay between monomer and multimer structure prediction for intertwined structures, etc. However, the structure predictions for orphan proteins and multimers remain challenging, and breakthroughs in this area are anticipated in the future.
Genetic and epigenetic prognosticators of neuroendocrine tumours of the GI tract, liver, biliary tract and pancreas: A systematic review and meta‐analysis

Multiple recurrent genetic and epigenetic aberrations have been associated with worse prognosis in multiple studies of neuroendocrine tumours (NETs), but these have been mainly small cohorts and univariate analysis. This review and meta‐analysis will focus upon the literature available on NETs of the gastrointestinal (GI) tract, liver, biliary tract and pancreas. PubMed and Embase were searched for publications that investigated the prognostic value of (epi)genetic changes of neuroendocrine tumours. A meta‐analysis was performed assessing the association of the (epi)genetic alterations with overall survival (OS), disease‐free survival (DFS) or locoregional control (LRC). In the pancreas DAXX/ATRX [hazard ratio (HR) = 3.29; 95% confidence interval (CI) = 2.28–4.74] and alternative lengthening telomeres (ALT) activation (HR = 8.20; 95% CI = 1.40–48.07) showed a pooled worse survival. In the small bowel NETs gains on chromosome 14 were associated with worse survival (HR 2.85; 95% CI = 1.40–5.81). NETs from different anatomical locations must be regarded as different biological entities with diverging molecular prognosticators, and epigenetic changes being important to the pathogenesis of these tumours. This review underpins the prognostic drivers of pancreatic NET which lie in mutations of DAXX/ATRX and ALT pathways. However, there is reaffirmation that prognostic molecular biomarkers of small bowel NETs should be sought in copy number variations (CNVs) rather than in single nucleotide variations (SNVs). This review also reveals how little is known about the prognostic significance of epigenetics in NETs.
SHFL inhibits enterovirus A71 infection by triggering degradation of viral 3Dpol protein via the ubiquitin–proteasome pathway

Enterovirus A71 (EV‐A71) is a highly contagious virus that poses a major threat to global health, representing the primary etiological agent for hand–foot and mouth disease (HFMD) and neurological complications. It has been established that interferon signaling is critical to establishing a robust antiviral state in host cells, mainly mediated through the antiviral effects of numerous interferon‐stimulated genes (ISGs). The host restriction factor SHFL is a novel ISG with broad antiviral activity against various viruses through diverse underlying molecular mechanisms. Although SHFL is widely acknowledged for its broad‐spectrum antiviral activity, it remains elusive whether SHFL inhibits EV‐A71. In this work, we validated that EV‐A71 triggers the upregulation of SHFL both in cell lines and in a mouse model. Knockdown and overexpression of SHFL in EVA71‐infected cells suggested that this factor could markedly suppress EV‐A71 replication. Our findings further revealed an intriguing mechanism of SHFL that it could interact with the nonstructural proteins 3Dpol of EV‐A71 and promoted the degradation of 3Dpol through the ubiquitin–proteasome pathway. Furthermore, the zinc‐finger domain and the 36 amino acids (164–199) of SHFL were crucial to the interaction between SHFL and EV‐A71 3Dpol. Overall, these findings broadened our understanding of the pivotal roles of SHFL in the interaction between the host and EV‐A71.
RetroGREAT signaling: The lessons we learn from yeast

The mitochondrial retrograde signaling (RTG) pathway of communication from mitochondria to the nucleus was first studied in yeast Saccharomyces cerevisiae. It rewires cellular metabolism according to the mitochondrial state by reprogramming nuclear gene expression in response to mitochondrial triggers. The main players involved in retrograde signaling are the Rtg1 and Rtg3 transcription factors, and a set of positive and negative regulators, including the Rtg2, Mks1, Lst8, and Bmh1/2 proteins. Retrograde regulation is integrated with other processes, including stress response, osmoregulation, and nutrient sensing through functional crosstalk with cellular pathways such as high osmolarity glycerol or target of rapamycin signaling. In this review, we summarize metabolic changes observed upon retrograde stimulation and analyze the progress made to uncover the mechanisms underlying the integration of regulatory circuits. Comparisons of the evolutionary adaptations of the retrograde pathway that have occurred in the different yeast groups can help to fully understand the process.
Evaluation of 28-day repeated doses oral toxicity of essential oil from Psidium glaziovianum Kiaersk leaves on various biological parameters in Swiss mice

ABSTRACT Only a small number of the many medicinally important species in the genus Psidium L. have had their safety assessed. Psidium glaziovianum, a plant native to Brazil, is reported to exert antinociceptive and anti-inflammatory effects; however, there are no apparent reports of long-term safety following administering of repeated doses. The aim of this study was to examine the effects of 28-day oral of treatment at 250, 500 or 1,000 mg/kg Psidium glaziovianum essential oil (PgEO) on behavioral and physiological parameters in male and female Swiss mice. First, PgEO was chemically characterized by gas chromatography mass spectrometry (GC-MS). The following parameters were examined: motor activity, body temperature, blood glucose, urine, hematology, biochemistry, histology, and oxidative stress. Characterization of PgEO revealed 48 components which were dominated by sesquiterpenes 1,8-cineol (24.29%), α-pinene (19.73%) and β-pinene (17.31%). Data showed that PgEO treatment in mice increased activities of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) without markedly affecting body weight, hematological or biochemical parameters, as well as water or food consumption. Administration of PgEO in repeated daily dosages over 28 days did not significantly alter exploratory or locomotor activities. Based upon our findings, PgEO administration daily for 28 days, exhibited low toxicity and absence of effects on the nervous system. Data demonstrated that PgEO produced hypoglycemic and antioxidant actions which need to be considered in safety assessment.
Facts on the ground : archaeological practice and territorial self-fashioning in Israeli society

Archaeology in Israel is truly a national obsession, a practice through which national identity and national rights have long been asserted. But how and why did archaeology emerge as such a pervasive force there? How can the practices of archaeology help answer those questions? In this stirring book, Nadia Abu El-Haj addresses these questions and specifies for the first time the relationship between national ideology, colonial settlement, and the production of historical knowledge. She analyzes particular instances of history, artifacts, and landscapes in the making to show how archaeology helped not only to legitimize cultural and political visions but, far more powerfully, to reshape them. Moreover, she places Israeli archaeology in the context of the broader discipline to determine what unites the field across its disparate local traditions and locations. Boldly uncovering an Israel in which science and politics are mutually constituted, this book shows the ongoing role that archaeology plays in defining the past, present, and future of Palestine and Israel. "
Target tracking algorithm based on node height regulate and considering node moving energy consumption

Aiming at the problem of low tracking accuracy caused by the sparse deployment of UWSN nodes in the process of target tracking based on underwater wireless sensor network (UWSN), a target tracking algorithm based on the regulate of node height and the consideration of node mobile energy consumption is proposed. First of all, the optimal height solution methods are given when the target height is known and unknown. Secondly, a dynamic coefficient is introduced to adjust the weight between tracking accuracy and energy consumption, and an objective function is established to comprehensively consider the target tracking accuracy and node moving energy consumption, so as to realize the dynamic regulate of node height. The simulation results show that the algorithm can achieve good and stable tracking effect and effectively reduce the energy consumption caused by node movement.
Diagnostik und Therapie der ankylosierenden Spondylarthritis – ein Update

Bornem Die ankylosierende Spondylarthritis stellt eine häufige rheumatologische Erkrankung dar, die nach wie vor diagnostisch und therapeutisch zahlreiche Herausforderungen bietet. Trotz besserem Verständnis der Pathogenese bleibt die diagnostische Abgrenzung zu den häufigeren unspezifischen Rückenschmerzen schwierig. Therapeutisch haben sich in der medikamentösen Behandlung ebenso wie bei den chirurgischen Verfahren neue Möglichkeiten ergeben. Der Artikel stellt ein Update zur Diagnostik und der Therapie der AS und den Entwicklungen der letzten Jahre dar.
Shared-bicycle demand forecast using convolutional LSTM network

Accurate and real-time bicycle demand forecasting helps shared-bicycle operators to allocate shared-bicycle more reasonably and efficiently. Thus making full use of resources and providing convenience for people to the greatest extent. We use convolutional LSTM to form Encoding-Forecasting Structure, and use open-source mobike data set of Beijing to train our model. By evaluating the model through these metrics RMSE,MAE,R2, we found that the Encoding-Forecasting Structure has better fitting ability and accuracy.
Study on spectral adaptive transformation based on chromatic aberration

The spectral reflectance of multispectral images can provide more valuable information about object characteristics. In order to improve the utilization of the spectrum, the reflectance reconstruction requires the same system calibration and illumination of the image acquisition. Therefore, Khan proposed the concept of multispectral constancy, which is to transform the multispectral image data into a standard representation through spectral adaptive transformation. Khan used the linear mapping method to solve SAT to convert the multispectral image data obtained under unknown illumination into the image data under standard light source. In order to further improve the spectral utilization rate and expand the application range of multispectral cameras, an algorithm to improve multispectral constancy based on chromatic aberration index is proposed in this paper. The algorithm uses chromatic aberration as the objective function to solve the spectral adaptive transformation. In this paper, ten light sources are used as unknown light sources, SFU and X-rite are used as training and testing datasets, and multispectral camera channels are simulated by Equi-Gaussian and Equi-Energy filters with different number of channels to train and test 5, 6, 8, and 10 channels of data. In this paper, the color difference under different light sources is used as the evaluation index to test the performance of the proposed algorithm, and compared with the Khan method for calculating SAT multispectral constancy. The experimental results show that the spectral constancy algorithm based on color difference can perform better, and expand the application of different kinds of unknown light sources in multispectral constancy.
The Determinants of International Tourism Demand for Egypt: Panel Data Evidence

Tourism industry has been an important contributor to the Egyptian economy. Egypt is one of the most important tourist destinations in the Middle East and North Africa. The purpose of this study is to recognize the main determinants of the international tourism flows to Egypt. The annual panel data set includes the number of tourist arrivals from most important generating countries during the period 1990-2008, and a number of possible explanatory variables.
Evaluating the usability of 3D thematic maps: A survey with visually impaired students

The pilot survey presented herein explores the possibilities given by three-dimensional (3D)-printed maps to students with visual impairment (VI) for learning the spatial distribution of geographic phenomena. The main research questions are: (a) whether students with VI can perceive two phenomena depicted on the same 3D-printed map and (b) whether they perform better when interacting with individual tactile maps for each spatial phenomenon than when interacting with a single 3D-printed map displaying the two spatial phenomena simultaneously. Our analysis indicates that 3D-printed maps can be a valuable alternative for the education of students with VI even when they represent two spatial phenomena simultaneously.
Diagnostic reliability in teledermatology: a systematic review and a meta-analysis

Objectives To compare teledermatology and face-to-face (F2F) agreement in primary diagnoses of dermatological conditions. Design Systematic review and meta-analysis Methods MEDLINE, Embase, Cochrane Library (Wiley), CINAHL and medRxiv were searched between January 2010 and May 2022. Observational studies and randomised clinical trials that reported percentage agreement or kappa concordance for primary diagnoses between teledermatology and F2F physicians were included. Titles, abstracts and full-text articles were screened in duplicate. From 7173 citations, 44 articles were included. A random-effects meta-analysis was conducted to estimate pooled estimates. Primary outcome measures were mean percentage and kappa concordance for assessing diagnostic matches between teledermatology and F2F physicians. Secondary outcome measures included the agreement between teledermatologists, F2F dermatologists, and teledermatology and histopathology results. Results 44 studies were extracted and reviewed. The pooled agreement rate was 68.9%, and kappa concordance was 0.67. When dermatologists conducted F2F and teledermatology consults, the overall diagnostic agreement was significantly higher at 71% compared with 44% for non-specialists. Kappa concordance was 0.69 for teledermatologist versus specialist and 0.52 for non-specialists. Higher diagnostic agreements were also noted with image acquisition training and digital photography. The agreement rate was 76.4% between teledermatologists, 82.4% between F2F physicians and 55.7% between teledermatology and histopathology. Conclusions and relevance Teledermatology can be an attractive option particularly in resource-poor settings. Future efforts should be placed on incorporating image acquisition training and access to high-quality imaging technologies. Trial registration number 10.17605/OSF.IO/FJDVG