Miracle-dz/UniFAR-FTUs huggingface dataset:
Toxicity of Three Optical Brighteners: Potential Pharmacological Targets and Effects on Caenorhabditis elegans

Optical brighteners (OBs) have become an integral part of our daily lives and culture, with a growing number of applications in various fields. Most industrially produced OBs are derived from stilbene, which has been found in environmental matrices. The main objectives for this work are as follows: first, to identify protein targets for DAST, FB-28, and FB-71, and second, to assess their effects in some behaviors physiologic of Caenorhabditis elegans. To achieve the first objective, each OB was tested against a total of 844 human proteins through molecular docking using AutoDock Vina, and affinities were employed as the main criteria to identify potential target proteins for the OB. Molecular dynamics simulations took and validated the best 25 docking results from two protein databases. The highest affinity was obtained for the Hsp70-1/DAST, CD40 ligand/FB-71, and CD40 ligand/FB-28 complexes. The possible toxic effects that OBs could cause were evaluated using the nematode C. elegans. The lethality, body length, locomotion, and reproduction were investigated in larval stage L1 or L4 of the wild-type strain N2. In addition, transgenic green fluorescent protein (GFP) strains were employed to estimate changes in relative gene expression. The effects on the inhibition of growth, locomotion, and reproduction of C. elegans nematodes exposed to DAST, FB-71, and FB-28 OBs were more noticeable with respect to lethality. Moreover, an interesting aspect in OB was increased the expression of gpx-4 and sod-4 genes associated with oxidative stress indicating a toxic response related to the generation of reactive oxygen species (ROS). In all cases, a clear concentration-response relationship was observed. It is of special attention that the use of OBs is increasing, and their different sources, such as detergents, textiles, plastics, and paper products, must also be investigated to characterize the primary emissions of OBs to the environment and to develop an adequate regulatory framework.
Stock Return Prediction Model in Indonesia

Stock returns are influenced by various things both external and internal. External factors that influence it include market sentiment and the circulation of information about the economy of the company's industry sector. Market sentiment is a reflection of the attitude and mood of investors towards the company. As a result, other investors try to anticipate the consequences of this attitude, so strategies emerge in investing. One of the strategies is the momentum of when to buy or sell an investment as a result of the investor's consideration of a situation to make their financial decision-making processes. This research aims to develop a model based on momentum estimations to determine when to buy and sell from each investment. Specifically, the study focuses on analysing the impacts of momentum factors along with beta, alpha and total risk factors on equity returns in Indonesia, using logistic regression to predict the likelihood of the returns. By combining influential factors, this model can make predictions with an accuracy of 85.6 per cent. The study has implications for investment strategy in Indonesia, particularly during episodes of downturn. The research is limited due to its reliance on the logistic regression model. This is the first study to include a momentum factor, along with beta, alpha, and total risk to predict the likelihood of equity returns in Indonesia. Keywords— Investment; Momentum; Return Prediction; Emerging Markets
Airborne microbes in five important regions of Chinese traditional distilled liquor (Baijiu) brewing: regional and seasonal variations

Baijiu is one of the six primary distilled spirits in the world. It is produced through the solid-state fermentation of grains in the open environment, so high-quality Baijiu brewing largely depends on terrior. Environmental microbes are one of the most important factors affecting the quality, quantity, and flavors of Baijiu. As atmosphere is a pool and transport pathway for microbes from the ambient environment to Baijiu brewing ecosystems, we explored the functional microbes of Baijiu brewing in five important regions. The regions fell into two topographical types, namely, plain and river-valley. In total, 41 functional microbes were identified rich (relative abundance >0.1%) in at least one of the regions, such as the fungi of Aspergillus, Candida, Cladosporium, Debaryomyces, Penicillium, Pichia, Rhizopus, Saccharomyces, and Wickerhamomyces and the bacteria of Acetobacter, Bacillus, Clostridium, Enterobacter, Lactobacillus, Methanosarcina, Methanobacterium, Methanobrevibacter, and Pseudomonas. However, some functional bacteria (e.g., Clostridia, Gluconacetobacter, and Weissella) and fungi (e.g., Dekkera, Eurotium, Issatchenkia, Mucor, and Phoma) were not rich or were not detected in the atmosphere. Airborne microbiomes and the Phylogenetic Diversity (PD) index were significantly different between the main brewing season (winter) and the summer break in each region, except for the fungi in one region. In winter, airborne microbiomes were significantly different among almost all the regions. The relative abundance of bacterial fermentation function in each region increased from summer to winter. The relative abundances of fungal yeast function were higher in winter for the plain regions but were higher in summer for the river-valley regions. In sum, our results suggested that: (1) atmosphere was one but not the sole important source of functional microbes for Baijiu brewing and (2) microbiomes in different regions might be quite different but they could share some major functions related to Baijiu brewing.
Edge-Side Fine-Grained Sparse CNN Accelerator With Efficient Dynamic Pruning Scheme

With the rapid development of the Internet of Things (IoT), it has become a common concern of academia and industry to provide real-time high performance services for edge-side applications and to bestow intelligence on massive edge-side devices. Due to the limitations of storage space, volume and power consumption of edge side devices, it is difficult for existing convolutional neural networks with large number of parameters and large amount of computation to match them. Network pruning can effectively alleviate the excessive parameters and computation issues in CNNs. However, fine-grained pruning is not hardware friendly, while other structured pruning schemes will result in a much higher loss of accuracy under the same compression ratio. In this paper, an model compression strategy is given including the proposed efficient fine-grained pruning scheme, a dynamic pruning & training method, and a weight importance judgment method. Depending on this strategy, sparse VGG16 (ResNet50) model can be obtained by training from scratch, and achieves a total of <inline-formula> <tex-math notation="LaTeX">$16\times $ </tex-math></inline-formula> compression ratio with 1/32 indexing overhead. Further, a light-weight, high-performance sparse CNN accelerator with modified systolic array is proposed. Implementing VGG16 and ResNet50 on the proposed accelerator, the experimental results show that compared with the most advanced design, the proposed accelerator can achieve 8.13 Frames Per Second (FPS) with <inline-formula> <tex-math notation="LaTeX">$2.17\times $ </tex-math></inline-formula> better power efficiency and at most <inline-formula> <tex-math notation="LaTeX">$4.14\times $ </tex-math></inline-formula> better calculation density.
Study on the shelf life and nutritional quality of cowpea (Vigna unguiculata L. Walp) and moth bean (Phaseolus aconitifolius Jacq.) sprouts

Title of Thesis : Study on the shelf life and nutritional quality of cowpea (Vigna unguiculata L. Walp) and moth bean (Phaseolus aconitifolius Jacq.) sprouts Full Name of the Degree Holder : SIMRAN ARORA Admission Number : 2011FST120M Title of the Degree : Master of Science Name of Discipline : Food Science and Technology Name and Address of Major Advisor : Dr. Saleem Siddiqui, Professor and Head Centre of Food Science and Technology CCS Haryana Agricultural University Hisar-125004 Degree Awarding University : CCS Haryana Agricultural University Hisar-125 004 (Haryana), India Year of Award of Degree : 2013 Major Subject : Food Science and Technology Total Number of Pages in Thesis : 48 + viii + I Number of Words in Abstract : 419
The Design of Broadband Circularly Polarized Multi-beam Antenna with Linearly Polarized Feeding Source and Transmitarray Unit

Among the existing circularly polarized multi-beam transmitarray antennas, circularly or linearly-to-circularly polarized transmitarray units are always required. Naturally, designing circularly polarized units is more challenging than linear polarization. To simplify design and increase operation bandwidth, a novel method using linearly polarized transmitarray units and feeding sources is proposed for designing the circularly polarized multi-beam antenna. Broadband circular polarization is realized by utilizing sequential rotation technology and 1-bit phase compensation of linearly polarized transmit-array units. Meanwhile, beam scanning is achieved by using linearly polarized feeding sources offset. To validate the design, two multi-beam antenna samples are demonstrated. Simulated and measured results show that the designed multi-beam transmitarray antennas can realize beam scanning to 0°, ±10°, and ±20° in E-plane and H-plane. Moreover, two antennas maintain –10-dB impedance bandwidth and 3-dB axial ratio (AR) bandwidth at 8.5–10.4 GHz and 8.5–10.5 GHz, respectively. The proposed circularly polarized multi-beam transmitarray antennas have the advantages of broadband operation, simple design, and low cost.
The Importance of Educational Expenditure Toward Human Resources Quality and Economic Growth: An Empirical Approach

This paper examines the critical significance of education in improving the calibre of human resources and stimulating economic development. This paper explores diversity and intricate ways in which education contributes to economic development through the enhancement of individual capabilities, the encouragement of inventive thinking, and the advancement of the general welfare of society. The paper emphasizes the critical need for significant public funding in education as a fundamental element for long-term economic progress and the improvement of personal well-being. By synthesizing empirical evidence and research findings from multiple studies, this paper provides substantial support for the notion that educational expenditure has a crucial influence on both economic growth and the development of high-quality human resources. It analyses the various manifestations and purposes of expenditures on education, illustrating its crucial contribution to the development of human capital, the improvement of productivity, and the general well-being of society. The discourse further delves into the strategic significance of education in the formulation of policies, arguing in Favor of its prioritization as a pivotal economic policy. Effective educational investment, according to the paper, is not only crucial for providing individuals with the necessary skills for gainful employment, but also for enhancing their earning capacity and promoting the generation of social value. In summary, the paper underscores the critical role that education plays in fostering social progress and economic prosperity. It is imperative that policymakers acknowledge the enduring advantages of education and allocate resources in a manner that guarantees its continued prominence in approaches designed to attain economic and social goals.
Transitioning from coal to solar: A cost-benefit analysis for sustainable power generation in Indonesia

The greenhouse gas (GHG) emissions contribution from power generation in Indonesia reaches 40% of the total (GHG) emissions in the energy sector because of the use of fossil fuels. The government aims to minimize GHG emissions in the power generation sector, one of which is the phase-out of coal power plants and replacing them with integrated photovoltaic (PV) power plants with battery energy storage systems (BESS). A cost-benefit analysis compared two development scenarios for 2023–2060. The base scenario continues developing coal power plants, and the phase-out scenario replaces coal power plants with integrated PV power plants and BESS. The analysis is solely focused on the financial costs and benefits for power plant investors. The results indicate that the present value of costs for the base scenario from 2023–2036 is initially lower compared to the phase-out scenario. However, in the long term, the costs of the phase-out scenario will gradually decrease and become more affordable. The benefit-cost ratio for the phase-out scenario is 2.36, while the base scenario is 2.12, indicating that the phase-out scenario is more prospective for future development. Additionally, the phase-out scenario has the advantage of achieving the net-zero emissions target by 2056 compared to the base scenario.
Bivariate step-stress accelerated life test for a new three-parameter model under progressive censored schemes with application in medical

In this article, a new three-parameter lifetime model called the Gull alpha power exponentiated exponential (GAPEE) distribution is introduced and studied by combining the Gull alpha power family of distributions and the exponentiated exponential distribution. The shapes of the probability density function (PDF) for the GAPEE distribution can be asymmetric shapes, like unimodal, decreasing, and right-skewed. In addition, the shapes of the hazard rate function (hrf) for the GAPEE distribution can be increasing, decreasing, and upside-down shaped. Several statistical features of the GAPEE distribution are computed. Eight estimation methods such as the maximum likelihood, Anderson-Darling, right-tail Anderson-Darling, left-tailed Anderson-Darling, Cramér-von Mises, least-squares, weighted least-squares, and maximum product of spacing are discussed to estimate the parameters of the GAPEE distribution. The flexibility and the importance of the GAPEE distribution were demonstrated utilizing three real-world datasets related to medical sciences. The GAPEE distribution is extremely adaptable and outperforms several well-known statistical models. A bivariate step-stress accelerated life test based on progressive type-I censoring using the model is presented. Minimizing the asymptotic variance of the maximum likelihood estimate of the log of the scale parameter at design stress under progressive type-I censoring yields an expression for the ideal test plan under progressive type-I censoring.
Relación entre Emisiones Contaminantes, Crecimiento Económico y Consumo de Energía. El caso de Ecuador 1971-2010

Abstract: The objective of this study is to investigate the relationship between pollutant emissions, economic growth and energy consumption in Ecuador for the period 1971-2010. The methodology is based in econometrics time series involving the same stationarity tests, vector autoregression (VAR) and Johansen cointegration was used. The results do not support the Environmental Kuznets Curve (EKC) hypothesis for the case of Ecuador; however, we can observe a monotonically increasing linear relationship, which states that GDP is associated with increased levels of CO 2 emissions in the long term; with respect to energy consumption (EC) is an inverse relationship in the long term, in other words, as energy consumption increases, GDP decreases found. Given the relationship between environmental degradation and product for the Ecuadorian case and taking into account the empirical evidence developed, Ecuador should seek mechanisms to help sustain its economic growth process without compromising the environment. Resumen: En este trabajo se busca comprobar si las emisiones contaminantes son el resultado del crecimiento economico y el consumo de energia en el Ecuador para el periodo 1971-2010. La metodologia se baso en econometria de series de tiempo las mismas que incluyeron pruebas de estacionaridad, vectores autorregresivos (VAR) y cointegracion de Johansen. Los resultados obtenidos permitieron concluir que la hipotesis de la Curva de Kuznets Ambiental (CKA) en forma de U invertida no se cumple para el caso ecuatoriano; sin embargo, se puede observar una relacion lineal monotona creciente, la cual senala que el PIB esta asociado a crecientes niveles de emisiones de CO 2 a largo plazo; con respecto al consumo de energia (CE) se encontro una relacion inversa en el largo plazo, es decir, a medida que aumenta el consumo de energia, el PIB disminuye. Dada la relacion entre degradacion ambiental y el PIB para el caso ecuatoriano y tomando en consideracion la evidencia empirica desarrollada, el Ecuador debera buscar mecanismos que ayuden a sostener su proceso de crecimiento economico sin comprometer el medio ambiente.
Smith ScholarWorks Smith ScholarWorks

Violence is a serious problems for cities like Chicago and has been exacerbated by the use of social media by gang-involved youths for taunting rival gangs. We present a corpus of tweets from a young and powerful female gang member and her communicators, which we have annotated with discourse intention, using a deep read to understand how and what triggered conversations to escalate into aggression. We use this corpus to develop a part-of-speech tagger and phrase table for the variant of English that is used, as well as a classiﬁer for identifying tweets that express grieving and aggression
The role of miRNAs in T helper cell development, activation, fate decisions and tumor immunity

T helper (Th) cells are central members of adaptive immunity and comprise the last line of defense against pathogen infection and malignant cell invasion by secreting specific cytokines. These cytokines then attract or induce the activation and differentiation of other immune cells, including antibody-producing B cells and cytotoxic CD8+ T cells. Therefore, the bidirectional communication between Th cells and tumor cells and their positioning within the tumor microenvironment (TME), especially the tumor immune microenvironment (TIME), sculpt the tumor immune landscape, which affects disease initiation and progression. The type, number, and condition of Th cells in the TME and TIME strongly affect tumor immunity, which is precisely regulated by key effectors, such as granzymes, perforins, cytokines, and chemokines. Moreover, microRNAs (miRNAs) have emerged as important regulators of Th cells. In this review, we discuss the role of miRNAs in regulating Th cell mediated adaptive immunity, focusing on the development, activation, fate decisions, and tumor immunity.
Transplantasi Hukum Ekonomi Syari`ah di Indonesia

Tulisan ini bertujuan untuk mengkaji bagaimana transplantasi hukum yang terjadi pada proses pembentukan hukum perbankan syariah, dan bagaimana solusi alternatif transplantasi pada hukum perbankan syariah. Metode yang digunakan adalah penelitian filosofis dengan menggunakan data sekunder yang berbasis pada kajian kepustakaan. Hasil penelitian menunjukan bahwa dalam pembentukan hukum perbankan syariah terbukti melakukan transplantasi hukum terutama pada perbankan-perbankan syariah yang sudah lama eksis di negara-negara lain di dunia muslim, seperti di mesir, pakistan, malaysia, arab saudi dan lain-lain. Dan salah satu hal yang menjadi solusi agar perbankan syariah ini mampu menjawab tantangan riba pada perbankan adalah dengan melakukan transplantasi hukum zakat kedalam hukum perbankan syariah.
Development of New Models of Oral Mucosa to Investigate the Impact of the Structure of Transmembrane Mucin-1 on the Mucosal Pellicle Formation and Its Physicochemical Properties

The mucosal pellicle (MP) is a biological film protecting the oral mucosa. It is composed of bounded salivary proteins and transmembrane mucin MUC1 expressed by oral epithelial cells. Previous research indicates that MUC1 expression enhances the binding of the main salivary protein forming the MP, MUC5B. This study investigated the influence of MUC1 structure on MP formation. A TR146 cell line, which does not express MUC1 natively, was stably transfected with genes coding for three MUC1 isoforms differing in the structure of the two main extracellular domains: the VNTR domain, exhibiting a variable number of tandem repeats, and the SEA domain, maintaining the two bound subunits of MUC1. Semi-quantification of MUC1 using dot blot chemiluminescence showed comparable expression levels in all transfected cell lines. Semi-quantification of MUC5B by immunostaining after incubation with saliva revealed that MUC1 expression significantly increased MUC5B adsorption. Neither the VNTR domain nor the SEA domain was influenced MUC5B anchoring, suggesting the key role of the MUC1 N-terminal domain. AFM-IR nanospectroscopy revealed discernible shifts indicative of changes in the chemical properties at the cell surface due to the expression of the MUC1 isoform. Furthermore, the observed chemical shifts suggest the involvement of hydrophobic effects in the interaction between MUC1 and salivary proteins.
Temperature and Precipitation Trend Analysis over the Last 30 Years in Southern Tigray Regional State, Ethiopia

Long term Precipitation and temperature variations are one of the main determinants of climate variability of one’s area. The aim of this study is to determine trends variation in climatic elements of temperature and precipitation in the southern zone of Tigray regional state, Ethiopia. The station is assumed for the study of climatic records over southern zone of the region in detection for probable trends. The daily, monthly and annual precipitation totals and temperature observed at korem meteorological station were used for the period of 1981-2010 for Precipitation and 1985 - 2010 for minimum and maximum temperature. Summary of descriptive statistics and Mann Kendall test methods were employed for the observed data analysis to demonstrate any existence of possible trends. The main findings of the study indicated that the mean and maximum temperature had a general increasing trend of 0.0013°C with high value of coefficient of determination (R2 = 0.004); however, minimum temperature showed decreasing trend of -0.1043°C. In general, annual temperature from 1985 - 2010 of the area showed a warming trend. Besides analysis of the 30 years (1981-2010) annual precipitation showed a coefficient of variation ranging from 33.77 - 233 %. It indicated that the precipitation dissemination of the area is not normal with large year to year variances. The observed warming temperature and fluctuation of rainfall is most likely explained by the increasing climate change and variability during the last decades in the area.
Do you remember your first drama lesson? Critical Incident methodologies for future practice

Reading accounts of the summer camps for drama education organised by the Hellenic Theatre/Drama & Education Network reminded me of an early inciting incident in my own drama teaching: working as an intern on a summer camp for children from remote and regional Western Australia while I was a student at university. In reflecting on the experience, I thought it important to do more than indulge in an exercise in nostalgia. In my current work as a semi-retired teacher at Murdoch University, I work with students on Critical Incident methodology. This article merges reflection and reflexivity as a process of personal professional growth.