Miracle-dz/UniFAR-FTUs huggingface dataset:
SECURITY ISSUES IN FLYING AD-HOC NETWORKS (FANETs)

Technological advancements in Unmanned Aerial Vehicles (UAV) encourage the use of multi-UAV systems in military and civil applications. The most important benefit of the multi-UAV system is to fulfill missions that require collaborative and cooperative behavior which depends on communication between UAVs. Flying Ad-Hoc Network (FANET) is a technique that both solves the coverage range problem between ground station and the UAVs; and supports real time data transfer without any infrastructure. FANET, which can be considered another type of ad-hoc network, holds all security issues of ad-hoc networks. Besides, it might also have new security problems, because it consists of UAVs. In this paper, FANET security limitations and challenges are surveyed. In addition, open research areas are also discussed.
Ictal Electroencephalographic Characteristics of Nodding Syndrome: A Comparative Case‐Series from South Sudan, Tanzania, and Uganda

Nodding syndrome (NS) is a poorly understood form of childhood‐onset epilepsy that is characterized by the pathognomonic ictal phenomenon of repetitive vertical head drops. To evaluate the underlying ictal neurophysiology, ictal EEG features were evaluated in nine participants with confirmed NS from South Sudan, Tanzania, and Uganda and ictal presence of high frequency gamma oscillations on scalp EEG were assessed. Ictal EEG during the head nodding episode predominantly showed generalized slow waves or sharp‐and‐slow wave complexes followed by electrodecrement. Augmentation of gamma activity (30–70 Hz) was seen during the head nodding episode in all the participants. We confirm that head nodding episodes in persons with NS from the three geographically distinct regions in sub‐Saharan Africa share the common features of slow waves with electrodecrement and superimposed gamma activity. ANN NEUROL 2022;92:75–80
Revision Hip Arthroscopy With Labral Reconstruction for Irreparable Labral Tears in Athletes: Minimum 2-Year Outcomes With a Benchmark Control Group

Background: The incidence of revision hip arthroscopy with labral reconstruction in athletes is increasing. However, the outcomes of revision hip arthroscopy with labral reconstruction in athletes have not been well established. Purposes: (1) To report minimum 2–year patient–reported outcome (PRO) scores and return to sports (RTS) characteristics for high–level athletes undergoing revision hip arthroscopy with labral reconstruction and (2) to compare clinical results with those of a propensity–matched control group of high–level athletes undergoing revision hip arthroscopy with labral repair. Study Design: Cohort study; Level of evidence, 3. Methods: Data were prospectively collected and retrospectively reviewed for athletes at any level who underwent a revision hip arthroscopy and a labral reconstruction between April 2010 and March 2019. Minimum 2–year PROs were reported for the modified Harris Hip Score (mHHS), the Nonarthritic Hip Score (NAHS), the Hip Outcome Score–Sport Specific Subscale (HOS-SSS), the visual analog scale (VAS) for pain, and RTS. The percentages of athletes achieving the minimal clinically important difference (MCID) and the maximum outcome improvement satisfaction threshold (MOIST) were also recorded. These patients were propensity matched in a 1: 1 ratio to athletes undergoing revision hip arthroscopy with labral repair for comparison. Results: A total of 46 athletes (N = 47 hips) were reported from 50 (n = 51 hips) athletes who underwent revision with labral reconstruction. A subanalysis of 30 propensity–matched athletes undergoing revision labral reconstruction was performed, with a mean follow–up time of 26.3 ± 2.4 months and an age of 28.5 ± 10.1 years, and compared with a revision labral repair group. Significant improvements were obtained for the mHHS, the NAHS, the HOS-SSS, and the VAS from preoperative to the latest follow–up (P < .001), with an achievement MCID rate of 61.5%, 72%, 62.5%, and 76.9% for the mHHS, the NAHS, the HOS-SSS, and the VAS, respectively. The rate for re–revision surgery (2 tertiary arthroscopy and 1 conversion to total hip arthroplasty) was 10%, and 14 patients (63.6%) were able to RTS. Improvements in PROs, rates of achieving MCID/MOIST, rate of re–revision surgery (re-revision hip arthroscopy, P = .671; conversion to total hip arthroplasty, P > .999), and RTS rate (P = .337) were similar when compared with those of the propensity–matched control labral repair group (P > .05). Conclusion: Revision hip arthroscopy with labral reconstruction, in the context of an irreparable labral tear, seems to be a valid treatment option in the athletic population, demonstrating significant improvements in all PROs and low rates of undergoing revision surgery. Athletes experienced a similar magnitude of improvement in PROs, RTS rate, and revision surgery rate to that of a propensity–matched control group of athletes undergoing revision hip arthroscopy with labral repair.
Changing Trends in Estrogen Receptors/Progesterone Receptors/Human Epidermal Growth Factor Receptor 2 Prevalence Rates Among Jordanian Patients With Breast Cancer Over the Years

PURPOSE Estrogen receptors (ERs), progesterone receptors (PRs), and human epidermal growth factor receptor 2 (HER2) are the mainstay of breast cancer management, and their prevalence rates vary among different populations possibly related to ethnic/genetic and/or socioeconomic status. In a previous study conducted at the King Hussein Cancer Center (published 2006), Jordan ER/PR/HER2 rates for patients diagnosed in 2003-2004 were 50.8%/57.5%/17.5%, respectively. The aim of this study is to revisit the prevalence rates to see if they have changed over the years with changing socioeconomic status. MATERIALS AND METHODS We retrieved clinicopathologic data of all patients (1,185) diagnosed with breast cancer during 2018. The data included age, histologic type, grade, and ER/PR/HER2 status as determined by immunohistochemistry and/or fluorescence in situ hybridization for HER2. RESULTS The mean age of patients was 52 (median = 51, range = 25-92) years, and the majority (73.2%) had invasive carcinoma of no special type. ER/PR/HER2 were 77.0%/72.4%. /23.8%, respectively. Triple-negative breast cancers were 10.1%. In comparison with previous results of 2006, the changes are statistically significant. Similar changes were seen in other Middle Eastern populations. The current rates are close to those of Western populations. CONCLUSION Rates of ER/PR/HER2 expression have significantly changed and are close to those of Western populations for ER/PR. We propose that such changes are secondary to the adoption of a westernized lifestyle and socioeconomic changes. Rates of ER/PR/HER2 expression have significantly changed over the years and approached Western population rates.
The effects of acute oral naltrexone pretreatment on the abuse potential of intranasal methamphetamine, and the relationship between reward/punishment sensitivity and methamphetamine’s effects

One potential medication for treating methamphetamine use disorder is the opioid antagonist naltrexone (NLTX). Despite encouraging preclinical findings, the results of clinical studies have been mixed. The primary aim of the current trial was to examine the effects of acute NLTX pretreatment on the subjective and reinforcing effects of intranasal methamphetamine. Nonmedical psychostimulant users completed outpatient testing sessions in which they received oral placebo (0 mg) or NLTX (50 mg) before intranasal methamphetamine (30 mg/70 kg). Primary outcome measures were peak positive subjective effects (e.g. drug ‘Liking’) assessed on a visual analog scale (0–100), and methamphetamine self-administration using an operant self-administration task. Participants also completed a probabilistic categorization task to assess reward and punishment learning sensitivity. Complete data were available from 13 male and 1 transgender (male-to-female) participant (age: 33.4 ± 7.6 years). Intranasal methamphetamine significantly increased subjective ratings of drug ‘Liking’, ‘Good Effect’ and ‘High’ from baseline (P’s < 0.01), but did not significantly vary as a function of placebo or NLTX pretreatment. Similarly, methamphetamine self-administration did not vary between the placebo and NLTX pretreatment conditions. This sample did not demonstrate a significant ‘bias’ in learning from positive and negative outcomes (i.e. reward and punishment sensitivity), and reward/punishment sensitivity was not correlated with the effects of methamphetamine or the effects of NLTX on methamphetamine. The current study argues against the use of NLTX as a stand-alone medication for treating methamphetamine use disorder.
Bayesci Genelleştirilmiş Lineer Karma Modellerde Önsel Seçimleri ve Karşılaştırılması

Parametre tahmininde ve model seciminde uzman goruslerin modele katilmasini ongoren Bayesci yaklasimda en onemli nokta parametreler hakkinda onsel bilgi secimi ve kullanimidir. Bu nedenle, bu calismada, onsel dagilimlarin secimleri tanitilmis, genellestirilmis lineer karma modeller icin farkli onseller ile elde edilen modeller hem parametre tahmini hem de model uyumu anlaminda karsilastirilmistir. Akciger kanseri hastalarinin yasam kaliteleri ve aldiklari tedavinin ciktilarini olcmek amaciyla yapilan bir calismaya ait gercek bir veri kullanilmistir. SAS 9.3 programinda Markov Zinciri Monte Carlo algoritmasi ile elde edilen parametre tahminleri bulunmus ve modeller kurulmustur. Farkli onsel secimleri ile Sapma Bilgi kriteri (DIC) ne gore en iyi model bilgilendirici onsel dagilim ile elde edilen model olmustur.
MCR-1-dependent lipid remodelling compromises the viability of Gram-negative bacteria

ABSTRACT The global dissemination of the mobilized colistin resistance gene, mcr-1, threatens human health. Recent studies by our group and others have shown that the withdrawal of colistin as a feed additive dramatically reduced the prevalence of mcr-1. Although it is accepted that the rapid reduction in mcr-1 prevalence may have resulted, to some extent, from the toxic effects of MCR-1, the detailed mechanism remains unclear. Here, we found that MCR-1 damaged the outer membrane (OM) permeability in Escherichia coli and Klebsiella pneumonia and that this event was associated with MCR-1-mediated cell shrinkage and death during the stationary phase. Notably, the capacity of MCR-1-expressing cells for recovery from the stationary phase under improved conditions was reduced in a time-dependent manner. We also showed that mutations in the potential lipid-A-binding pocket of MCR-1, but not in the catalytic domain, restored OM permeability and cell viability. During the stationary phase, PbgA, a sensor of periplasmic lipid-A and LpxC production that performed the first step in lipid-A synthesis, was reduced after MCR-1 expression, suggesting that MCR-1 disrupted lipid homeostasis. Consistent with this, the overexpression of LpxC completely reversed the MCR-1-induced OM permeability defect. We propose that MCR-1 causes lipid remodelling that results in an OM permeability defect, thus compromising the viability of Gram-negative bacteria. These findings extended our understanding of the effect of MCR-1 on bacterial physiology and provided a potential strategy for eliminating drug-resistant bacteria.
An Extremely Low‐Frequency Vortex Magnetic Field Modifies Protein Expression, Rearranges the Cytoskeleton, and Induces Apoptosis of a Human Neuroblastoma Cell Line

Homogeneous extremely low‐frequency electromagnetic fields (ELF‐EMFs) alter biological phenomena, including the cell phenotype and proliferation rate. Heterogenous vortex magnetic fields (VMFs), a new approach of exposure to magnetic fields, induce systematic movements on charged biomolecules from target cells; however, the effect of VMFs on living systems remains uncertain. Here, we designed, constructed, and characterized an ELF‐VMF‐modified Rodin's coil to expose SH‐SY5Y cells. Samples were analyzed by performing 2D‐differential‐gel electrophoresis, identified by MALDI‐TOF/TOF, validated by western blotting, and characterized by confocal microscopy. A total of 106 protein spots were differentially expressed; 40 spots were downregulated and 66 were upregulated in the exposed cell proteome, compared to the control cell proteome. The identified spots are associated with cytoskeleton and cell viability proteins, and according to the protein–protein interaction network, a significant interaction among them was found. Our data revealed a decrease in cell survival associated with apoptotic cells without effects on the cell cycle, as well as evident changes in the cytoskeleton. We demonstrated that ELF‐VMFs, at a specific frequency and exposure time, alter the cell proteome and structurally affect the target cells. This is the first report showing that VMF application might be a versatile system for testing different hypotheses in living systems, using appropriate exposure parameters. © 2022 Bioelectromagnetics Society.
Leveraging single‐cell sequencing to unravel intratumour heterogeneity and tumour evolution in human cancers

Intratumour heterogeneity (ITH) and tumour evolution are well‐documented phenomena in human cancers. While the advent of next‐generation sequencing technologies has facilitated the large‐scale capture of genomic data, the field of single‐cell genomics is nascent but rapidly advancing and generating many new insights into the complex molecular mechanisms of tumour biology. In this review, we provide an overview of current single‐cell DNA sequencing technologies, exploring how recent methodological advancements have enumerated new insights into ITH and tumour evolution. Areas highlighted include the potential power of single‐cell genome sequencing studies to explore evolutionary dynamics contributing to tumourigenesis through to progression, metastasis, and therapy resistance. We also explore the use of in situ sequencing technologies to study ITH in a spatial context, as well as examining the use of single‐cell genomics to perform lineage tracing in both normal and malignant tissues. Finally, we consider the use of multimodal single‐cell sequencing technologies. Taken together, it is hoped that these many facets of single‐cell genome sequencing will improve our understanding of tumourigenesis, progression, and lethality in cancer, leading to the development of novel therapies. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
DNAH14 variants are associated with neurodevelopmental disorders

Neurodevelopmental disorders (NDD) are complex and multifaceted diseases involving genetic and environmental sciences. Rapid developments in sequencing techniques have made it possible to identify new disease‐causing genes. Our study aimed to identify novel genes associated with NDDs. Trio whole‐exome sequencing was performed to evaluate potential NDD variants. We identified three unrelated patients with compound heterozygous DNAH14 variants. The detailed clinical information and genetic results of the recruited patients were obtained and systematically reviewed. Three compound heterozygous DNAH14 variants were identified as follows: c.6100C > T(p.Arg2034Ter) and c.5167A > G(p.Arg1723Gly), c. 12640_12641delAA(p.Lys4214Valfs*7) and c.4811T > A(p.Leu1604Gln), andc.7615C > A(p.Pro2539Thr) and c.11578G > A(p.Gly3860Ser), including one nonsense, one frameshift, and four missense variants, which were not existent or with low minor allele frequencies based on the gnomAD database. The missense variants were assumed to be damaging or probably damaging by using multiple bioinformatics tools. Four of these variants were located in the AAA+ ATPase domain, while two were located in the C‐terminal domain. Most affected amino acids were highly conserved in various species. A spectrum of neurological and developmental phenotypes was observed, including seizures, global developmental delay, microcephaly, and hypotonia. Thus, our findings indicate that variants of DNAH14 could lead to previously unrecognized NDDs.
Supervised Learning in Multilayer Spiking Neural Networks With Spike Temporal Error Backpropagation

The brain-inspired spiking neural networks (SNNs) hold the advantages of lower power consumption and powerful computing capability. However, the lack of effective learning algorithms has obstructed the theoretical advance and applications of SNNs. The majority of the existing learning algorithms for SNNs are based on the synaptic weight adjustment. However, neuroscience findings confirm that synaptic delays can also be modulated to play an important role in the learning process. Here, we propose a gradient descent-based learning algorithm for synaptic delays to enhance the sequential learning performance of single spiking neuron. Moreover, we extend the proposed method to multilayer SNNs with spike temporal-based error backpropagation. In the proposed multilayer learning algorithm, information is encoded in the relative timing of individual neuronal spikes, and learning is performed based on the exact derivatives of the postsynaptic spike times with respect to presynaptic spike times. Experimental results on both synthetic and realistic datasets show significant improvements in learning efficiency and accuracy over the existing spike temporal-based learning algorithms. We also evaluate the proposed learning method in an SNN-based multimodal computational model for audiovisual pattern recognition, and it achieves better performance compared with its counterparts.
Crying in the first 12 months of life: A systematic review and meta‐analysis of cross‐country parent‐reported data and modeling of the “cry curve”

Abstract Crying is an ubiquitous communicative signal in infancy. This meta‐analysis synthesizes data on parent‐reported infant cry durations from 17 countries and 57 studies until infant age 12 months (N = 7580, 54% female from k = 44; majority White samples, where reported, k = 18), from studies before the end Sept. 2020. Most studies were conducted in the United States, the United Kingdom, and Canada (k = 32), and at the traditional cry “peak” (age 5–6 weeks), where the pooled estimate for cry and fuss duration was 126 mins (SD = 61), with high heterogeneity. Formal modeling of the meta‐analytic data suggests that the duration of crying remains substantial in the first year of life, after an initial decline.
Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Lung Cancer Risk: Results from a Pooled Analysis of Case–Control Studies (SYNERGY)

Abstract Background: Exposure to polycyclic aromatic hydrocarbons (PAH) occurs widely in occupational settings. We investigated the association between occupational exposure to PAH and lung cancer risk and joint effects with smoking within the SYNERGY project. Methods: We pooled 14 case–control studies with information on lifetime occupational and smoking histories conducted between 1985 and 2010 in Europe and Canada. Exposure to benzo[a]pyrene (BaP) was used as a proxy of PAH and estimated from a quantitative general population job-exposure matrix. Multivariable unconditional logistic regression models, adjusted for smoking and exposure to other occupational lung carcinogens, estimated ORs, and 95% confidence intervals (CI). Results: We included 16,901 lung cancer cases and 20,965 frequency-matched controls. Adjusted OR for PAH exposure (ever) was 1.08 (CI, 1.02–1.15) in men and 1.20 (CI, 1.04–1.38) in women. When stratified by smoking status and histologic subtype, the OR for cumulative exposure ≥0.24 BaP μg/m3-years in men was higher in never smokers overall [1.31 (CI, 0.98–1.75)], for small cell [2.53 (CI, 1.28–4.99)] and squamous cell cancers [1.33 (CI, 0.80–2.21)]. Joint effects between PAH and smoking were observed. Restricting analysis to the most recent studies showed no increased risk. Conclusions: Elevated lung cancer risk associated with PAH exposure was observed in both sexes, particularly for small cell and squamous cell cancers, after accounting for cigarette smoking and exposure to other occupational lung carcinogens. Impact: The lack of association between PAH and lung cancer in more recent studies merits further research under today's exposure conditions and worker protection measures.
RISK ANALYSIS FOR THE FIRE SAFETY OF AIRLINE PASSENGERS.

The purpose of this report is to describe the National Institute of Standards and Technology’s work to date relating to the general methodology being developed for the project Risk Analysis for the Fire Safety of Airline Passengers and the software being used to facilitate this methodology. The approach selected involved the use of influence diagrams. Therefore, a brief discussion of influence diagrams is given. The status of their application to the water mist system for passenger planes is given and the overall approach to carrying out the project is described. An example is included that shows how the process works, but the case is fictional, not intended to be realistic. report is to describe the National Institute of Standards and Technology's work to date relating to the general methodology being developed for the project Risk Analysis for the Fire Safety of Airline Passengers and the software being used to facilitate this methodology. The approach selected involved the use of influence diagrams. Therefore, a brief discussion of influence diagrams is given. The status of their application to the water mist system for passenger planes is given and the overall approach to carrying out the project is described. An example is included that shows how the process works, but the case is fictional, not intended to be realistic.
Characteristic Resistive Switching of Rare-Earth Oxyhydrides by Hydride Ion Insertion and Extraction.

Resistive switching induced by ion migration is promising for applications such as random-access memory (ReRAM) and neuromorphic transistors. Hydride ions (H-) are an interesting candidate as the migration ion for resistive switching devices because they have fast diffusion in several compounds at room temperature and doping/dedoping can be used effectively to achieve significant changes in the electronic conductivity. Here, we report reversible resistive switching characteristics in rare-earth oxyhydrides (REHxO(3-x)/2) induced by field insertion/extraction of H-. The current-voltage measurements revealed that the resistive switching response, hysteresis, and switching voltage vary greatly with the H-/O2- ratio in the films. We fabricated a ReRAM device using Ti/YH1.3O0. 85/MoOx structure and confirmed the bipolar-type operation with the resistance switching ratio of 1 order of magnitude over 1000 cycles. The composition gradient of H-/O2- in YHxO(3-x)/2 films, in addition to the hydrogen-absorbing ability of the top electrode, is essential for effective device operation. Our findings show that hydride-conducting solid-state electrolytes are suitable for resistive switching device development.
Study on Performance of Adaptive Maximum Torque Per Amp Control in Induction Motor Drives at Light Load Operation

Efficient operation of induction motor at light loads has been getting wide attention recently because the operating of induction motor at light loads occupies big portion of its operating regions in many applications such as environment friendly vehicle. As one of approaches to improve efficiency, Adaptive Maximum Torque Per Amp (Adaptive MTPA) control for induction motor drives has been proposed to achieve a desired torque with the minimum possible stator current. However, the Adaptive MTPA control was validated only at heavy load where, in general, control scheme tends to perform better than at light loads since the error in measurement of sensors is lower and signal to noise is better. Thus, although the performance of a control scheme is good at rated operating point, its performance at light load is somewhat in doubt in practice. This has led to considerable interest in efficiency of Adaptive MTPA control at light loads. This work experimentally demonstrates performance of Adaptive MTPA control at light loads regardless of rotor resistance variation, thus showing its good performance over all operating conditions.