Miracle-dz/UniFAR-FTUs huggingface dataset:
Quality Evaluation of Market Acacia catechu by Fingerprint-Chemical Pattern Recognition

Acacia catechu (L.f.) Willd, a leguminous plant, is included in the 2020 edition of the Chinese Pharmacopoeia and is mainly used to treat eczema, mouth ulcers, diarrhea, bruising, and traumatic hemorrhage. However, there are imported and domestic Acacia catechu samples available in China, and their quality and price are very different, which seriously affects the safety and stability of their clinical application. Importantly, there is no simple and effective method for identifying or classifying grades of Acacia catechu. In this study, 47 batches of commercial Acacia catechu were used for identifying or classifying grades of Acacia catechu using high performance liquid chromatography (HPLC) combined with chemometric analysis. Firstly, gradient elution was adopted with 0.05% phosphoric acid water (A)-methanol (B) as the mobile phase to establish chromatographic conditions. The HPLC chromatograms of 47 batches of Acacia catechu samples were analyzed by the “Similarity Evaluation System for Chromatographic Fingerprint of TCM” software (version 2012A). The common peaks of Acacia catechu were identified to evaluate the similarity. Based on the determination results of fingerprint chromatographic peak area, the quality of the collected Acacia catechu was evaluated by chemometric methods such as CA, PCA, and OPLS-DA. The results showed that the collected Acacia catechu samples were significantly divided into three categories. The first-class samples were all imported Acacia catechu except S9 sample, which was domestic Acacia catechu; the second-class samples were partly domestic Acacia catechu and partly imported Acacia catechu; and the third-class samples were all domestic Acacia catechu. Moreover, OPLS-DA of 47 batches of samples showed that the contents of catechin and the total contents of catechin and epicatechin could be used as key indicators for assessing the quality of Acacia catechu. The developed HPLC fingerprint and quantitative analysis method of multi-indicator components can be used for classification and quality evaluation of market Acacia catechu, which has a significant reference value for developing Acacia catechu grade quality standards.
Measuring Epidemiologic Effects of Enterococcal Bacteremia and Outcomes From a Nationwide Inpatient Sample Database

Introduction Enterococcus is a gram-positive, non-sporing, facultative anaerobe. It is a common cause of nosocomial infections in the United States. Enterococcal bacteremia is primarily a nosocomial infection in the medical intensive care unit (ICU), with a preference for elderly patients with multiple comorbidities. Material and methods This is a retrospective cohort study using the publicly accessible National (Nationwide) Inpatient Sample (NIS) database from October 2015 to December 2017. We examined data from 75,430 patients aged 18 years and older in the NIS who developed enterococcal bacteremia, as identified from the ICD-10 CM codes (B95), to discuss the epidemiologic effects and outcomes of enterococcal bacteremia. Patients were classified based on demographics, and comorbidities were identified. Three primary outcomes were studied: in-hospital mortality, length of stay, and healthcare cost. The secondary outcome was identifying any comorbidities associated with enterococcal bacteremia. Length of stay was defined as days from admission to discharge or death. Healthcare costs were estimated from the hospital perspective from hospital-level ratios of costs-to-charges. SAS 9.4 (2013; SAS Institute Inc., Cary, North Carolina, United States) was used for univariate and multivariate analyses. For data analysis, mortality was modeled using logistic regression. Length of stay and costs were modeled using linear regression, controlling for patient and hospital characteristics. Statistical analyses were performed using SAS. Statistical significance was defined as P<0.05. Results A total of 75,430 patients with enterococcal bacteremia were included in the study. Of this, 44,270 were males and 31,160 females. A total of 50,270 (68.67%) were Caucasians, 11,210 (15.31%) were African Americans, 6,445 (8.80%) were Hispanic and 2,025 (2.77%) were native Americans. Important comorbidities were congestive heart failure (25.91%), valvular disease (8.08%), neurological complications (11.87%), diabetes mellitus with complications (18.89%), renal failure (28.52%), and obesity (11.61%). In-hospital mortality was 11.07%, length of stay was 13.8 days, and a healthcare cost of 41,232.6 USD. Conclusions Enterococcal bacteremia is a nosocomial infection with a preference for the elderly with renal failure, cardiac failure, cardiac valvular diseases, stroke, obesity, and diabetes with complications. Further studies are needed to see whether the mortality caused by enterococcal bacteremia is attributable to comorbidities or to the bacteremia. It is associated with a more extended hospital stay and higher healthcare expenditure. Implementing contact precautions to contain the spread of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus(VRE) has also checked the spread of enterococci. Further prospective studies can be planned using chart-based data.
The Role of Parents in Online Learning Motivation for Sixth-Grade Elementary School Students

This research sought to determine how parental roles affected children's motivation for online learning during the COVID-19 pandemic. This study employed a quantitative correlational survey as its methodology. The questionnaire was used to collect data for this study. While SEM-PLS (Structural Equation Modeling-Partial Least Square) analysis is used to test hypotheses, CFA (Confirmatory Factor Analysis) is used to assess validity and reliability. SmartPLS 3.0 software is used to assist in all data processing. The factor analysis results indicated a sufficient correlation between the 30 items of the instruments used to support the structure of each variable. According to the results of the SEM analysis, parents significantly impact their children's desire to learn online at home when it comes to the online learning system utilized by elementary school students. Four indicators measure parents' performance: providing guidance (PG), learning facilities (LF), rewards and praise (RP), and attention and supervision (AS) (AS). The results of this study indicate that parental roles (LF, PG, and RP) affect learning motivation, as indicated by P-values of (0.000 0.05), (0.035 0.05), and (0.006 0.05), respectively. In contrast, US indicators have no effect on parental roles and learning motivation, as indicated by the P-value of (0.879 0.05 In order to improve the home education system while still leaving a positive impression on children, parents' roles must become more child-centered. Due to their rigorous nature, the instrument validity techniques of CFA and the data analysis techniques of SEM enhance the validity and reliability of research findings
The impact of mental simulation on subsequent tourist experience – dual evidence from eye tracking and self-reported measurement

ABSTRACT Tourism research has always sought to find ways to improve tourists’ experience evaluation and create added value for them. However, the academic community has focused on the on-site and post-travel stages of tourists, and neglected the pre-travel stage. This study examines the influence of guided mental simulation of an upcoming tourist experience on subsequent on-site tourist experience and experience evaluation. The research simulated real-world experience with tour videos shot from the first-person perspective, and measured the variables using both eye movements and self-reporting. Multivariate ANOVA and multigroup analysis were then performed on the data. The results showed that a process simulation of tourists having an engagement experience and an outcome simulation of tourists having a sight-seeing experience resulted in a higher engagement level and higher emotional response during the on-site experience, higher evaluation of the experience, and a greater impact of engagement level on their evaluation. This study expands the research on tourists’ psychological experience in the pre-travel stage. Results indicate that the period from the moment consumers book or purchase the tourist product to the moment they actually embark on the tourist experience is a valuable marketing window.
An Effective Approach for Automated Lung Node Detection using CT Scans

Background: Pulmonary or benign nodules are classified as nodules with a diameter of 3 cm or less and defined as non-cancerous nodules. The early diagnosis of malignant lung nodules is important for a more reliable prognosis of lung cancer and less invasive chemotherapy and radiotherapy procedures. Objective: This study aimed to introduce an improved hybrid approach for efficient nodule mask generation and false-positive reduction. Material and Methods: In this experimental study, nodule segmentation preprocessing was conducted to prepare the input computed tomography (CT) scans for the U-Net convolutional neural network (CNN) model, and includes the normalization of CT scans and transfer of pixel values corresponding to the radiodensity of Hounsfield Units (HU). A U-Net CNN was developed based on lung CT scans for nodule identification. Results: The U-net model converged to a dice coefficient of 0.678 with a sensitivity of 75%. Many false positives were considered in every real positive, at 11.1, reduced in the proposed CNN to 2.32 FPs (False Positive) per TP (True Positive). Conclusion: Based on the disadvantages of the largest nodule, the similarity of extracted features of the current study with those of others was imperative. The improved hybrid approach introduced was useful for other image classification tasks as expected.
The Influence of Financial Behaviour on Financial Risk Tolerance In Investment Decision: A Conceptual Paper

There is a growing stream of research to seek for a solution to improve financial risk tolerance (FRT) in investment decisions, which is most likely conducted from financial institutions and was revealed that there are varieties of factors contribute to this aspect. The literature demonstrated that FRT is considered as the powerful factor that encourages investors’ intentions towards investments. Study shows that the FRT can be improved through positive financial behaviour. Hence it is essential to explore financial behaviour and FRT influences in investment decision from studies around the world and Malaysian market. Therefore, this wide discussion will benefit financial practitioners and institutions in financial practices. In addition, this study surely contribute some additional insights towards existing literature.
Repetitive Transcranial Magnetic Stimulation for Neuropathic Pain and Neuropsychiatric Symptoms in Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Neuropathic pain and neuropsychiatric symptoms are common complications reported by the traumatic brain injury (TBI) population. Although a growing body of research has indicated the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for the management of neurological and psychiatric disorders, little evidence has been presented to support the effects of rTMS on neuropathic pain and neuropsychiatric symptoms in patients with TBI in all age groups. In addition, a better understanding of the potential factors that might influence the therapeutic effect of rTMS is necessary. The objective of this preregistered systematic review and meta-analysis was to quantify the effects of rTMS on physical and psychological symptoms in individuals with TBI. We systematically searched six databases for randomized controlled trials (RCTs) of rTMS in TBI patients reporting pain and neuropsychiatric outcomes published until March 20, 2022. The mean difference (MD) with 95% confidence intervals (CIs) was estimated separately for outcomes to understand the mean effect size. Twelve RCTs with 276 TBI patients were ultimately selected from 1605 records for systematic review, and 11 of the studies were included in the meta-analysis. Overall, five of the included studies showed a low risk of bias. The effects of rTMS on neuropathic pain were statistically significant (MD = −1.00, 95% CI -1.76 to -0.25, P = 0.009), with high heterogeneity (I2 = 76%). A significant advantage of 1 Hz rTMS over the right dorsolateral prefrontal cortex (DLPFC) in improving depression (MD = −6.52, 95% CI -11.58 to -1.46, P = 0.01) was shown, and a significant improvement was noted in the Rivermead Post-Concussion Symptoms Questionnaire-13 (RPQ-13) scores of mild TBI patients after rTMS (MD = −5.87, 95% CI -10.63 to -1.11, P = 0.02). However, no significance was found in cognition measurement. No major adverse events related to rTMS were reported. Moderate evidence suggests that rTMS can effectively and safely improve neuropathic pain, while its effectiveness on depression, postconcussion symptoms, and cognition is limited. More trials with a larger number of participants are needed to draw firm conclusions. This trial is registered with PROSPERO (PROSPERO registration number: CRD42021242364.
Statistical Facts of Artificial Stock Market

The paper reports the construction of artificial stock market that emerges the similar statistical facts with real data in Indonesian stock market. We use the individual but dominant data, i.e.: PT TELKOM in hourly interval. The artificial stock market shows standard statistical facts, e.g.: volatility clustering, the excess kurtosis of the distribution of return, and the scaling properties with its breakdown in the crossover of Levy distribution to the Gaussian one. From this point, the artificial stock market will always be evaluated in order to have comprehension about market process in Indonesian stock market generally.
Borna disease virus antigen distribution in naturally infected bicolored white-toothed shrews, Crocidura leucodon, supporting its role as reservoir host species

: Borna Disease is a severe, immunopathological disorder of the central nervous system, caused by infection with Borna Disease Virus (BDV). The main known naturally affected animal species in endemic areas in central Europe are horses and sheep[24]. In this study we present evidence of shrew mice (Crocidura leucodon) as a vector of BDV. The widespread presence of viral antigen and –RNA in the organs of this animal species without producing pathological lesions differs from the classical hosts such as equines, small ruminants and other domestic animals naturally infected with BDV. The detection of BDV in the shrew mice was achieved by immunohistochemistry and by TaqMan® Real Time RT-PCR. RT-PCR mplification products were sequenced, and the sequences were compared with those from horses and sheep originating from the same geographical region, which had died from Borna Disease (BD). Borna disease virus antigen distribution in naturally infected bicolored white-toothed shrews, Crocidura leucodon, supporting its role as reservoir host ABSTRACT Borna Disease is a severe, immunopathological disorder of the central nervous system, caused by infection with Borna Disease Virus (BDV). The main known naturally affected animal species in endemic areas in central Europe are horses and sheep[24]. In this study we present evidence of shrew mice (Crocidura leucodon ) as a vector of BDV. The widespread presence of viral antigen and –RNA in the organs of this animal species without producing pathological lesions differs from the classical hosts such as equines, small ruminants and other domestic animals naturally infected with BDV. The detection of BDV in the shrew mice was achieved by immunohistochemistry and by TaqMan ® Real Time RT-PCR. RT-PCR amplification products were sequenced, and the sequences were compared with those from horses and sheep originating from the same geographical region, which had died from Borna Disease (BD). Joest-Degen
REFERENCE VALUE FOR HIGH-SENSITIVITY C-REACTIVE PROTEIN IN THE NORTHERN PAKISTANI POPULATION

Objective: High- sensitivity C - reactive protein (hS-CRP) is an acute phase protein that is often used for the risk estimation of cardiovascular diseases. Objective was to find out the reference range of hS-CRP in the healthy adult northern Pakistani population and compare the distribution in relation with age, gender, body mass index (BMI), ethnicity and smoking. Study Design: Cross-sectional study Place and Duration of Study: Army Medical College Rawalpindi from Nov 2007 - Mar 2009 Subjects and Methods: In this cross-sectional study a total of 297 healthy adults (>18 years) comprising 207 males, 90 females, Punjabis (n=178) and Pathans (n=119) were randomly included from Rawalpindi, Lahore, Peshawar and Sawabi Districts. History and clinical examination were carried out. Serum hS-CRP was analysed in Clinical Pathology Laboratory, Army Medical College Rawalpindi by two site sequential chemiluminiscent immunometric assay kit on immulite 1000(USA). Data were analysed by SPSS-16. Results: The reference values for hS-CRP are presented as median (2.5th-97.5th percentile). In the healthy adult population of Northern Pakistan it was 1.84 mg/L (0.37-4.81) mg/l; in Punjabis 1.75 (0.30-4.65) mg/l and in Pathans 1.93 (0.50-5.30) mg/l. Females had higher hS-CRP levels 2.05 (0.53-5.66) mg/l as compared to the males1.76 (0.31-5.06) mg/l. Smokers had relatively higher hS-CRP 1.98 mg/l (0.47-5.56) mg/l than non-smokers 1.68 mg/l (0.30-4.60). Our data also revealed that hS-CRP had significant positive correlation with advancing age (r=0.20; p <0.05) and increasing BMI (r=0.29; p <0.01). Conclusion: The reference range for hS-CRP in the population of Northern Pakistan is 0.37-4.81 mg/l. Pathans have higher hS-CRP levels than Punjabis. Demographic factors including age and BMI were positively correlated to the distribution of hS-CRP.
Intraspecies allometric equations derived using phase 1 clinical adult pharmacokinetic parameters for pediatric dosing of lamivudine, nevirapine, and zidovudine

The aim of this study was to simulate pediatric pharmacokinetic parameters using data from a clinical trial in healthy adults who were administered a pediatric fixed-dose combination of lamivudine (3TC)/zidovudine (AZT)/ nevirapine (NVP) (30/60/50 mg) granules for reconstitution and fast disintegrating tablets. Using the area under the curve (AUC) from noncompartmental analysis, the relative bioavailability of the test suspension and test tablet to the reference suspension was 93.7% and 104.5% for lamivudine, 82.9% and 97.9% for nevirapine, and 94.2% and 93.6% for zidovudine, respectively. The 90% CI for C max , AUC 0–t , and AUC t–∞ were 85.69%–102.54%, 96.13%–117.79%, and 82.63%–106.72%, respectively, for lamivudine; 83.33%–109.15%, 99.94%–124.54%, and 98.22%–122.43%, respectively, for zidovudine; and 87.71%–109.20%, 89.31%–106.26%, and 85.95%–102.82%, respectively, for nevirapine. Pharmacokinetic parameters were generated using the pharmacokinetics (PK) PK TM module in GastroPlus ® modeling and simulation software. Pediatric pharmacokinetic parameters were simulated using adult clinical data and pediatric physiologic variables as inputs to the PK TM module. The resulting virtual pediatric subjects’ PK data were regressed against pediatric body weight (BW), body surface area (BSA), and postgestational age (PGA), respectively. Clearance and volume of distribution were linearly correlated with BW ( R 2 = 1.000) but obeyed the polynomial equation of the third order with the PGA of the subjects ( R 2 ubjects . Simulation of pediatric pharmacokinetic parameters using adult PK data and pediatric physiologic parameters as input produced pediatric PK total clearance and volume of distribution, which were linearly correlated with BW but polynomially correlated with the PGA of children. By making appropriate allowances for a specific enzyme’s maturation rate and presence, allometric scaling of pediatric doses of antiretroviral drugs lamivudine, nevirapine, and zidovudine could be more reliably determined using a linear expression based on BW and BSA and polynomial expression based on child’s PGA of up 12 years.
OUTBURSTS BY LOW-MASS WHITE DWARFS IN SYMBIOTIC VARIABLES

We have investigated the nature of P Cygni-like features in the high resolution IUE spectra of the symbiotic variables BF Cyg and EG And by looking for orbital phase-dependent variations in the structure and velocity of the C IV (1550 A) resonance doublet in 10 archival IUE high-dispersion spectra of these systems and by comparing their profiles with P Cygni-like features seen in IUE high-dispersion spectra of other symbiotic stars. For BF Cyg, we find maximal P Cygni absorption equivalent widths and terminal velocities of 900 mA and -240 Km s-1 respectively, full emission velocity widths at the 10% intensity level of 300-400 km s-1, depending on phase, Phi, variations in the width of the P Cygni absorption, shortward velocity shifts of the C IV emission line in all but two orbital phases, relative to the C IV velocity at Phi = 0.01, and absorption sub-structure within the C IV P Cygni lines which coincide in velocity from image to image. In EG And the C IV P Cygni absorption equivalent width is, on average, 300 mA with a terminal velocity of -217 km s-1 (which includes the systemic radial velocity contribution of -93 km s-1). The presence in one image, of a strong absorption feature at He II (1640), having a precise velocity coincidence with the C IV P Cygni absorption component, suggests that the absorbing material responsible for both line features is associated with outflow and P Cygni self-absorption from the vicinity of the hot component. In both BF Cyg and EG And, the structure and behavior of the P Cygni profiles may rule out their origin in the red giant wind or in an expanding circumbinary shell. Our results support the hot component wind interpretation of Mikolajewska et al. (1989). Motivated by the low-mass white dwarf shown to be present in BF Cyg (Mikolajewska et al. 1989), we have carried out quasi-static evolutionary model calculations with accretion onto a 0.55 solar mass white dwarf accreting at the rate of 2 X 10-8 solar mass yr-1. The sequence of 3800 quasi-static models, the first to be reported for a low-mass hot white dwarf (Mwd < 0.8 solar mass) accreting at a high rate, yields an unexpected outburst behavior in response to accretion at that rate, when compared to evolutionary sequences with accretion onto higher mass white dwarfs. A series of three major thermonuclear shell flashes and one lower energy shell flash is revealed with the timescale during outburst and the inter-outburst timescale substantially shorter than expected for a 0.55 solar mass white dwarf. Implications for the observations of symbiotic systems thought to contain low-mass white dwarfs, are discussed.
Search for the rare radiative decay W→πγ in pp̄ collisions at √s=1.96TeV

Department of Energy (US); National Science Foundation (US); Istituto Nazionale di Fisica Nucleare (Italia); Ministry of Education, Culture, Sports, Science and Technology (Japan); National Research Council of Canada; Swiss National Science Foundation; Alfred P. Sloan Foundation; Bundesministerium fur Bildung und Forschung (Deutschland); National Research Foundation of Korea; Science and Technology Facilities Council (UK); The Royal Society (UK); Russian Foundation for Basic Research; Ministerio de Ciencia e Innovacion (Espana); Slovak Research and Development Agency; Academy of Finland; Australian Research Council.