Miracle-dz/UniFAR-FTUs huggingface dataset:
Usefulness of Ultrasound Examination in the Assessment of the Nail Apparatus in Psoriasis

The assessment of psoriatic nail changes in everyday practice is based exclusively on clinical symptoms that do not reflect the entire disease process in the nail apparatus. The use of imaging methods, especially widely available and inexpensive ultrasonography, creates the possibility of additional revealing and assessing grayscale of morphological changes of the ventral nail plate, nail bed, and matrix, as well as the attachment of the finger extensor tendon to the distal phalanx. What is more, it enables the assessment of inflammation severity in the power Doppler technique. A qualitative classification of nail plate morphological changes corresponding to the severity of psoriatic nail changes has been developed so far and attempts are being made to develop a quantitative method to assess not only the presence of changes but also the severity of inflammation. Nail ultrasonography is not commonly performed, although published studies indicate the possible use of this technique in the assessment of psoriatic changes in nail structures. It can be particularly useful in subclinical changes imaging, preceding clinical manifestation of psoriatic nail changes, enthesopathy: subclinical and in the course of psoriatic arthritis, as well as in the assessment of treatment efficacy. This review article aims to summaries the research on ultrasonography of the nail apparatus which has been carried out so far, taking into account its applicability in clinical practice.
Wearable Devices for Physical Monitoring of Heart: A Review

Cardiovascular diseases (CVDs) are the leading cause of death globally. An effective strategy to mitigate the burden of CVDs has been to monitor patients’ biomedical variables during daily activities with wearable technology. Nowadays, technological advance has contributed to wearables technology by reducing the size of the devices, improving the accuracy of sensing biomedical variables to be devices with relatively low energy consumption that can manage security and privacy of the patient’s medical information, have adaptability to any data storage system, and have reasonable costs with regard to the traditional scheme where the patient must go to a hospital for an electrocardiogram, thus contributing a serious option in diagnosis and treatment of CVDs. In this work, we review commercial and noncommercial wearable devices used to monitor CVD biomedical variables. Our main findings revealed that commercial wearables usually include smart wristbands, patches, and smartwatches, and they generally monitor variables such as heart rate, blood oxygen saturation, and electrocardiogram data. Noncommercial wearables focus on monitoring electrocardiogram and photoplethysmography data, and they mostly include accelerometers and smartwatches for detecting atrial fibrillation and heart failure. However, using wearable devices without healthy personal habits will cause disappointing results in the patient’s health.
Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes

Background Several studies have suggested that increased oxidative stress during pregnancy may be associated with adverse maternal and foetal outcomes. As selenium is an essential mineral with an antioxidant role, our aim was to perform a systematic review of the existing literature reporting the effects of selenium supplementation during pregnancy on maternal and neonatal outcomes. Materials and Methods Six electronic databases (Medline, Embase, Cochrane Library, Web of Science, Scopus, and PubMed) were searched for studies reporting the effects of selenium supplementation during pregnancy and the postpartum period on maternal and neonatal outcomes. Only randomised controlled trials on human subjects reported in English and published up to October 2021 were included. Quality assessments were conducted using the modified Downs and Black quality assessment tool. Data were extracted using a narrative synthesis. Results Twenty-two articles were included in our systematic review (seventeen reported on maternal outcomes, two on newborn outcomes, and three on both). Maternal studies reported the effects of selenium supplementation in the prevention of thyroid dysfunction, gestational diabetes, pregnancy-induced hypertension/preeclampsia, oxidative stress, postpartum depression, premature rupture of membranes, intrauterine growth retardation, breastmilk composition, and HIV-positive women. Newborn studies reported the effects of maternal selenium supplementation on foetal oxidation stress, foetal lipid profile, neonatal hyperbilirubinemia, and newborn outcomes in HIV-positive mothers. The majority of studies were inappropriately designed to establish clinical or scientific utility. Of interest, four studies reported that selenium supplementation reduced the incidence of thyroid dysfunction and permanent hypothyroidism during the postpartum period by reducing thyroid peroxidase and thyroglobulin antibody titres. Conclusion The evidence supporting selenium supplementation during pregnancy is poor and there is a need for appropriately designed randomised controlled trials before routine use can be recommended.
Influence factors and spatiotemporal patterns of environmental sound levels in the contiguous United States

Environmental sound levels represent the cumulative contributions of many types - and possibly an uncountable number - of sound sources. This recommends a statistical approach to modeling. Using 1.5 million hours of acoustical data from hundreds of sites, regression models were built to predict sound levels across the contiguous United States. These models discern often nonlinear and interacting relationships between measured sound levels and nonacoustic environmental summaries extracted from nationwide geospatial data layers. Tens of potential explanatory factors were examined including climate, topography, human activity, and time of day and year. Mapping sound levels at landscape scales and diagnostic tools, like partial dependence functions, can reveal the effects of influential factors on measured sound levels. These results illustrate the foundations of many spatiotemporal patterns, provide tools for understanding current acoustical conditions and demonstrate the potential consequences of shifts in environmental conditions.
Overexpression of Soybean GmWRI1a Stably Increases the Seed Oil Content in Soybean

WRINKLED1 (WRI1), an APETALA2/ethylene-responsive-element-binding protein (AP2/EREBP) subfamily transcription factor, plays a crucial role in the transcriptional regulation of plant fatty acid biosynthesis. In this study, GmWRI1a was overexpressed in the soybean cultivar ‘Dongnong 50’ using Agrobacterium-mediated transformation to generate three transgenic lines with high seed oil contents. PCR and Southern blotting analysis showed that the T-DNA was inserted into the genome at precise insertion sites and was stably inherited by the progeny. Expression analysis using qRT-PCR and Western blotting indicated that GmWRI1a and bar driven by the CaMV 35S promoter were significantly upregulated in the transgenic plants at different developmental stages. Transcriptome sequencing results showed there were obvious differences in gene expression between transgenic line and transgenic receptor during seed developmental stages. KEGG analysis found that the differentially expressed genes mainly annotated to metabolic pathways, such as carbohydrated metabolism and lipid metabolism. A 2-year single-location field trial revealed that three transgenic lines overexpressing GmWRI1a (GmWRI1a-OE) showed a stable increase in seed oil content of 4.97–10.35%. Importantly, no significant effect on protein content and yield was observed. Overexpression of GmWRI1a changed the fatty acid composition by increasing the linoleic acid (C18:2) content and decreasing the palmitic acid (C16:0) content in the seed. The three GmWRI1a-OE lines showed no significant changes in agronomic traits. The results demonstrated that the three GmWRI1a overexpression lines exhibited consistent increases in seed oil content compared with that of the wild type and did not significantly affect the seed yield and agronomic traits. The genetic engineering of GmWRI1a will be an effective strategy for the improvement of seed oil content and value in soybean.
A novel and efficient synthesis of 1, 2, 3,4-tetrahydropyrimidine carboxamide derivatives by Biginelli reaction and their in vitro antibacterial activity

Introduction and Aim: An efficient aspect of two step synthesis of tetrahydro pyrimidine carboxamide derivatives were developed by Biginelli reaction. The two-step synthesized 1,2,3,4-tetrahydropyrimidinecarboxamide compounds were evaluated by In-vitro studies like antifungal and bacterial activities. Few compounds were shown excellent zone of inhibition against fungal and Microbial activities. In this study showed significant effect of antifungal and bacterial action against tetrahydro pyrimidine derivatives. Materials and Methods: In this procedure to synthesize 1,2,3,4-tetrahydropyrimidinecarboxamide derivatives, ethyl acetoacetate, cytosine, para-toluene sulphonic acid and ethanol were used. Results: The synthesized compounds of 1,2,3,4-tetrahydropyrimidine carboxamide derivatives through Biginelli reaction used an efficient catalyst such as para-toluene sulphonic acid and solvent ethanol. In this study tested compounds have developed into two step protocol for synthesis of diversely substituted novel pyrimidines. Conclusion: In this study the synthesized 1,2,3,4-tetrahydropyrimidine carboxamide (THPC) shows significant inhibiting action against Gram +ve, Gram –ve bacterial and fungal growth.
Targeting the NOD-, LRR- and Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome in Psoriasis and Fatigue

Inflammasomes are intracellular, multi-protein signaling complexes of the innate immune system that activate and control inflammatory responses in nucleated cells. Among these inflammasomes, the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome, a cytosolic sensor that modulates inflammatory responses in nucleated cells upon detection of various danger signals and microbial motifs, has been shown to a play a role in a wide range of pathologies and associated symptomatologies, including psoriasis and associated fatigue. Activation of the NLRP3 inflammasome can lead to caspase-1-dependent release of inflammatory cytokines, which potentially act on surrounding cells and may contribute to symptoms of fatigue. In this review, we will present recent developments in NLRP3 inflammasome research as it relates to psoriasis and fatigue, with a focus on the intracellular signaling pathways governing NLRP3 inflammasome regulation and promising pharmacological therapeutics that inhibit NLRP3 inflammasomal pathways.
Crop rotation to diversify the soil microbiome in the semi-arid area of Inner Mongolia, China

ABSTRACT The introduction of leguminous crops for crop rotation can mitigate the negative effects of continuous cropping on soil health. In this experiment, we designed ten cropping patterns to optimise the rotation effect with different combinations of crop types, planting years, and order in a mainly potato-growing region. A 5-year cycle with three crops, undertaken in Inner Mongolia since 2009, was used to test soil properties and microbial structure. The relative abundance of plant growth-promoting bacteria (PGPB) was 32.1% in the cycle oats oats alfalfa alfalfa alfalfa and 22.4% in 5-year mono-cropping of alfalfa, which was higher than that of mono-cropping of potatoes and other crop rotations. Soil moisture was the main factor influencing bacterial and fungal communities. The effect of the type of plant introduced into the rotation on soil was greater than that of the number of years a certain crop was planted in the rotation, and this effect was greater than that of planting order. The findings suggest that the rotation of oats and alfalfa mixed → alfalfa → oats → potatoes → potatoes is a suitable 5-year cycle to maintain biodiversity and better soil physico-chemical properties for sustainable agriculture.
An Analysis of Environmental Dimensions Affected in Adoption of Hydrogen Fuel Cell Vehicles: A Study in Shah ALAM Industrial AREA, Selangor

The aim of the study is to identify the perceptions of respondents on environmental dimensions hat affected in adoption of hydrogen fuel cell vehicles. The study was conducted at Shah Alam industrial areas of Selangor, Malaysia, with the number of respondents are 120 respondents with various job positions that related with engineering and automobiles industry. The findings of the research shows that the dimensions of HFCV Internal Environmental total score of the items statement is 3.40 with the percentage of agreement in implementation is 3.72 percent, HFCV Environmental Information Systems shows that the total score of the items statement is 3.63 with the percentage of agreement on use to great extend is 42.5 percent, HFCV Cooperation with Customers shows that the total score of the items statement is 3.81 with the percentage of agreement on implementation is 44.2 percent. The findings on HFCV Eco Design shows that the total score of items statement is 4.02 with the percentage of agreement on implementation is 42.3 percent, HFCV Environmental Organizational Culture shows that the total score of the items statement is 3.37 with the percentage of agreement is 34.2 percent, HFCV Environmental Leadership shows that the total score of the items statement is 3.34 with the percentage of agreement is 48.2 percent. HFCV Proactive Green Innovation shows that the total score of items statement is 4.10 ahead of automobile got the highest mean score of 4.32 with the percentage of agreement is 41 percent. HFCV Environmental performance shows that the total score of the items statement is 3.87 with the percentage of agreement is 39 percent and the last environmental dimensions was HFCV Environmental Risks shows that the total score of the item statement is 4.00 with the percentage of agreement is 40 percent
Privacy-preserving Information Security for the Energy Grid of Things

: Smart grid infrastructure relies on information exchange between multiple actors in order to ensure system reliability. These actors include but are not limited to smart loads, grid control, and energy management technologies. As information exchange between these actors is susceptible to cyber-attacks, security and privacy issues are indispensable to ensure a reliable and stable grid. This position paper proposes a privacy-preserving, trust-augmented secure scheme for a smart grid implementation.
Infrastructural Sector and Corporate Image: Evidence from India

In recent years, the corporate image concept has attracted a lot of interest among managers, consultants and academics, as it is perceived by many to be of pivotal importance to companies in a marketplace where differentiation is increasingly difficult these days. Lots of studies have been conducted on the topic by the earlier researchers; still there has been a lack of systematic conceptual knowledge on the term “corporate image in infrastructural sector”. This research work is an attempt to synthesize some of the key prior research on the concept corporate image and its effect on consumer loyalty. The purpose of the study was also to measure the impact of brand awareness and service quality on developing corporate image in telecommunication, a basic infrastructural sector in Patna, India.
Path planning of mobile robot by mixing experience with modified artificial potential field method

In this article, a new method is proposed to help the mobile robot to avoid many kinds of collisions effectively, which combined past experience with modified artificial potential field method. In the process of the actual global obstacle avoidance, system will invoke case-based reasoning algorithm using its past experience to achieve obstacle avoidance when obstacles are recognized as known type; otherwise, it will invoke the modified artificial potential field method to solve the current problem and the new case will also be retained into the case base. In case-based reasoning, we innovatively consider that all the complex obstacles are retrieved by two kinds of basic build-in obstacle models (linear obstacle and angle-type obstacle). Our proposed experience mixing with modified artificial potential field method algorithm has been simulated in MATLAB and implemented on actual mobile robot platform successfully. The result shows that the proposed method is applicable to the dynamic real-time obstacle avoidance under unknown and unstructured environment and greatly improved the performances of robot path planning not only to reduce the time consumption but also to shorten the moving distance.
The possibility of using anti-human monoclonal antibody CD3 as pan T-cell marker in guinea pigs

The present study was aimed to evaluate the possibility of using anti-human monoclonal antibody CD3 as pan T-cell marker in the guinea pigs’ trachea and lung in early and late manifestations of the allergic inflammatory process. Materials and methods.We have studied the distribution and quantitative changes of CD3-positive lymphocytes in trachea and lung of guinea pigs using histological, immunohistochemical, statistical methods in conditions of experimental inflammatory process. Results. Our results revealed the applicability of anti-Human monoclonal antibody CD3 (Clone SP7, «DAKO», Denmark) cross-reaction with T-cells of guinea pigs’ tracheas and lungs. The most statistically significant elevation of the number of CD3-positive lymphocytes, in comparison with the control group (p*/**<0.05), observed in the experimental group III in the late stages of experimental inflammatory process. The elevation of the number of CD3-positive lymphocytes persists even after the termination of the allergen action, which indicates the continuation of the reaction of pulmonary local adaptive immunity to the allergen. Conclusions. The results of our study may be useful in conditions of the deficiency of guinea pig-specific tests. The immunohistochemical assessment of guinea pigs’ trachea and lungs proved the possibility to use anti-Human monoclonal antibody CD3 as a panT-cell marker in guinea pigs. We demonstrated the activation of adaptive immune response (T-cells), represented by their immunohistochemical changes, predominantly in the late stages of experimental inflammatory process.
Docking and Ligand Binding Affinity: Uses and Pitfalls

In this review article, we will explore the foundations of different classes of docking and scoring functions, their possible limitations, and their suitable application domains. We also provide assessments of several scoring functions on weakly-interacting protein-ligand complexes, which will be useful information in computational fragment-based drug design or virtual screening.
BACTERIOCIN ASSOCIATED GENES IN FRENCH AND UKRAINIAN FERMENTED VEGETABLE ISOLATES OF LACTIPLANTIBACILLUS PLANTARUM

Lactiplantibacillus plantarum species is known for the high diversity of the loci encoding bacteriocin (plantaricin) production. The aim of this work was to study the distribution of pln genes in French and Ukrainian isolates of L. plantarum originated from fermented plant material. PCR with the primers to plnA, plnB, plnC, plnD, plnEF, plnI, plnK, plnJ, plnG, plnN, plnW genes was performed to find out the peculiarities of L. plantarum strains. French and Ukrainian isolates shared none of the identical combinations of genes from plantaricin regulon indicating the diversity of pln loci in L. plantarum of fermented plant origin from the distant geographical regions. Certain combinations of genes from plantaricin regulon could be proposed as indicators marking the geographical origin of L. plantarum strains. Among the studied isolates, some resembled the described in the literature L. plantarum strains, and others contained unique combinations of pln genes.
Vortex-induced vibration of a tube array with a large pitch-to-diameter ratio value

To study the vortex-induced vibration behaviors of tube arrays with large pitch-to-diameter ratio values, an experiment has been conducted by testing the responses of an elastically mounted tube in a fixed normal triangular tube array with five rows and a pitch-to-diameter ratio value of 2.5 in a water tunnel subjected to cross-flow. The amplitude curves, power spectral density, and response frequencies were obtained in both in-line and transverse directions through the experiment. The results show that the responses obtained from the in-line direction are quite different from those obtained from the transverse direction. In the in-line vibration, there were two excitation regions, yet in the transverse vibration, there was only one excitation region. Moreover, in the in-line vibration, two obvious prominent peaks can be observed in the power spectral density of the vibration signal. The second prominent peak is a subharmonic peak. The frequency corresponding to the subharmonic peak was nearly twice as high as that corresponding to the first peak. However, in the transverse vibration, only a single broad peak existed in the power spectral density of the vibration signal. The hysteresis and the “lock-in” phenomena appeared in both the in-line and transverse vibrations. The results of study are beneficial for designing and operating devices mounted with large pitch-to-diameter ratio tube arrays, and for further research on the vortex-induced vibration of tube arrays.
Evaluación nutracéutica de un pan tipo coyota a partir de harinas de trigo, frijol y nopal con mermelada de higo

En el presente trabajo se desarrolló un pan tipo coyota a partir de una harina compuesta de trigo, frijol y nopal. La coyota obtenida con la mezcla 80%, 18% y 2% de harinas de trigo, frijol y nopal presentó 14.0%, 49.58%, y 16.18% en el contenido de proteína, carbohidratos y lípidos, respectivamente. En comparación con las coyotas comerciales, la coyota formulada contiene 100% más proteína y 16% y 17% menos carbohidratos y grasas, respectivamente. Demuestra un contenido de fenoles totales de 0.65 mg EAG/g y una capacidad antioxidante de 0.05 mg ET/g evaluada por el método de ABTS. De acuerdo con esto, se generó un producto natural, innovador y nutritivo y de valor agregado usando productos de la región centro norte del estado de Zacatecas.
Velocity estimation in digital controlled DC servo drives

This paper deals with the design of the extended observer in a digital control system for a DC servomotor. The suggested extended observer is able both to estimate the shaft speed and to filter the quantized signal from the position transducer. The developed observer enables proper estimation of the plant state variables, even in the case of the constant or a slow varying load torque disturbances. Useful procedures for the adjustment of observer gains are proposed and verified.