Miracle-dz/UniFAR-FTUs huggingface dataset:
Development and prognosis of hepatocellular carcinoma in patients with diabetes

The incidence of diabetes mellitus and hepatocellular carcinoma (HCC) has been increasing worldwide during the last few decades, in the context of an increasing prevalence of obesity and non-alcoholic fatty liver disease (NAFLD). Epidemiologic studies have revealed that patients with diabetes have a 2- to 3-fold increased risk of developing HCC, independent of the severity and cause of the underlying liver disease. A bidirectional relationship exists between diabetes and liver disease: advanced liver disease promotes the onset of diabetes, and HCC is an important cause of death in patients with diabetes; conversely, diabetes is a risk factor for liver fibrosis progression and HCC development, and may worsen the long-term prognosis of patients with HCC. The existence of close interconnections among diabetes, obesity, and NAFLD causes insulin resistance-related hyperinsulinemia, increased oxidative stress, and chronic inflammation, which are assumed to be the underlying causes of hepatocarcinogenesis in patients with diabetes. No appropriate surveillance methods for HCC development in patients with diabetes have been established, and liver diseases, including HCC, are often overlooked as complications of diabetes. Although some antidiabetic drugs are expected to prevent HCC development, further research on the optimal use of antidiabetic drugs aimed at hepatoprotection is warranted. Given the increasing medical and socioeconomic impact of diabetes on HCC development, diabetologists and hepatologists need to work together to develop strategies to address this emerging health issue. This article reviews the current knowledge on the impact of diabetes on the development and progression of HCC.
Impact of claudin‐10 deficiency on amelogenesis: Lesson from a HELIX tooth

In epithelia, claudin proteins are important components of the tight junctions as they determine the permeability and specificity to ions of the paracellular pathway. Mutations in CLDN10 cause the rare autosomal recessive HELIX syndrome (Hypohidrosis, Electrolyte imbalance, Lacrimal gland dysfunction, Ichthyosis, and Xerostomia), in which patients display severe enamel wear. Here, we assess whether this enamel wear is caused by an innate fragility directly related to claudin‐10 deficiency in addition to xerostomia. A third molar collected from a female HELIX patient was analyzed by a combination of microanatomical and physicochemical approaches (i.e., electron microscopy, elemental mapping, Raman microspectroscopy, and synchrotron‐based X‐ray fluorescence). The enamel morphology, formation time, organization, and microstructure appeared to be within the natural variability. However, we identified accentuated strontium variations within the HELIX enamel, with alternating enrichments and depletions following the direction of the periodical striae of Retzius. These markings were also present in dentin. These data suggest that the enamel wear associated with HELIX may not be related to a disruption of enamel microstructure but rather to xerostomia. However, the occurrence of events of strontium variations within dental tissues might indicate repeated episodes of worsening of the renal dysfunction that may require further investigations.
A cross-sectional study of dental students perception of dental faculty gender differences

Objective The objective of this study was to evaluate students’ perceptions of differences in learning from faculty of different gender. Method This cross-sectional study involved pre-doctoral dental students (years 2 to 4) who had a simulation and/or clinical experience working with dental faculty for at least one year. Students completed a self-administered questionnaire with three sections: demographic, difference between faculty related to their knowledge, skill, critical thinking, acceptance of cultural differences, and students’ preferences in working with faculty in specialty clinics. Results A total of 136 students completed the survey (75.4% response rate). Participants were 52.6% women, 62.2% self-identified as Caucasian/White. Students reported that female faculty are more understanding (p = 0.001) and accepting of cultural differences (p<0.001) compared to male faculty (p<0.05). Students reported perceiving female faculty more as being a role model than male faculty (p = 0.034). When comparing male and female students, male student’s perception of male faculty as a role model was significantly higher than female students (p<0.05). There was no significant difference in student’s perceptions between male and female faculty in their knowledge, skills, compassion, critical thinking, providing feedback, communication skills, and grading (p>0.05). Caucasian/White students perceived female faculty as more encouraging for discussions and male faculty as more rigid/inflexible (p<0.05). Conclusions Students perceived female faculty as more understanding and culturally competent compared to male faculty. There were no significant differences in student’s perceptions of male and female faculty in their knowledge, skills, compassion, critical thinking, feedback, communication skills, and grading. Students perceived female faculty as role models more than male faculty.
Structure of measures for which Ehrhard symmetrization is perimeter non-increasing

In this paper, we prove that isotropic Gaussian functions are characterized by a rearrangement inequality for weighted perimeter in dimensions $n \ge 2$ within the class of non-negative weights in $L^1(\mathbb{R}^n) \cap W^{1,1}_{loc}(\mathbb{R}^n)$. More specifically, we prove that within this class generalized Ehrhard symmetrization is perimeter non-increasing for all Borel sets $E$ in all directions $\vec{v}$ if and only if the distribution function is an isotropic Gaussian.
Computing Components of Everyday Stress Responses: Exploring Conceptual Challenges and New Opportunities

Repeated assessments in everyday life enables collecting ecologically valid data on dynamic, within-persons processes. These methods have widespread utility and application and have been extensively used for the study of stressors and stress responses. Enhanced conceptual sophistication of characterizing intraindividual stress responses in everyday life would help advance the field. This article provides a pragmatic overview of approaches, opportunities, and challenges when intensive ambulatory methods are applied to study everyday stress responses in “real time. ” We distinguish between three stress-response components (i.e., reactivity, recovery, and pileup) and focus on several fundamental questions: (a) What is the appropriate stress-free resting state (or “baseline”) for an individual in everyday life? (b) How does one index the magnitude of the initial response to a stressor (reactivity)? (c) Following a stressor, how can recovery be identified (e.g., when the stress response has completed)? and (d) Because stressors may not occur in isolation, how can one capture the temporal clustering of stressors and/or stress responses (pileup)? We also present initial ideas on applying this approach to intervention research. Although we focus on stress responses, these issues may inform many other dynamic intraindividual constructs and behaviors (e.g., physical activity, physiological processes, other subjective states) captured in ambulatory assessment.
Direction decoding of imagined hand movements using subject-specific features from parietal EEG

Objective. Research on the decoding of brain signals to control external devices is rapidly emerging due to its versatile potential applications, including neuroprosthetic control and neurorehabilitation. Electroencephalogram (EEG)-based non-invasive brain–computer interface (BCI) systems decode brain signals to establish an augmented communication and control pathway between the brain and the computer. The development of an efficient BCI system requires accurate decoding of neural activity underlying the user’s intentions. This study investigates the directional tuning of EEG characteristics from the posterior parietal region, associated with bidirectional hand movement imagination or motor imagery (MI) in left and right directions. Approach. The imagined movement directions of the chosen hand were decoded using a combination of envelope and phase features derived from parietal EEGs of both hemispheres. The proposed algorithm uses wavelets for spectral decomposition, and discriminative subject-specific subband levels are identified based on Fisher analysis of envelope and phase features. The selected features from the discriminative subband levels are used to classify left and right MI directions of the hand using a support vector machine classifier. Furthermore, the performance of the proposed algorithm is evaluated by incorporating a maximum-variance-based EEG time bin selection algorithm. Main results. With the time bin selection approach using subject-specific features, the proposed algorithm yielded an average left vs right MI direction decoding accuracy of 73.33% across 15 healthy subjects. In addition, the decoding accuracy offered by the phase features was higher than that of the envelope features, indicating the importance of phase features in MI kinematics decoding. Significance. The results reveal the significance of the parietal EEG in decoding of imagined kinematics and open new possibilities for future BCI research.
Developmental patterns of affective attention across the first 2 years of life

Abstract This study examined patterns of attention toward affective stimuli in a longitudinal sample of typically developing infants (N = 357, 147 females, 50% White, 22% Latinx, 16% African American/Black, 3% Asian, 8% mixed race, 1% not reported) using two eye‐tracking tasks that measure vigilance to (rapid detection), engagement with (total looking toward), and disengagement from (latency to looking away) emotional facial configurations. Infants completed each task at 4, 8, 12, 18, and 24 months of age from 2016 to 2020. Multilevel growth models demonstrate that, over the first 2 years of life, infants became faster at detecting and spent more time engaging with angry over neutral faces. These results have implications for our understanding of the development of affect‐biased attention.
EARLY DIFFERENTIATION BETWEEN SEPSIS AND STERILE INFLAMMATION VIA URINARY GENE SIGNATURES OF METABOLIC DYSREGULATION

ABSTRACT Objective: The aim of this study was to characterize early urinary gene expression differences between patients with sepsis and patients with sterile inflammation and summarize in terms of a reproducible sepsis probability score. Design: This was a prospective observational cohort study. Setting: The study was conducted in a quaternary care academic hospital. Patients: One hundred eighty-six sepsis patients and 78 systemic inflammatory response syndrome (SIRS) patients enrolled between January 2015 and February 2018. Interventions: Whole-genome transcriptomic analysis of RNA was extracted from urine obtained from sepsis patients within 12 hours of sepsis onset and from patients with surgery-acquired SIRS within 4 hours after major inpatient surgery. Measurements and Main Results: We identified 422 of 23,956 genes (1.7%) that were differentially expressed between sepsis and SIRS patients. Differentially expressed probes were provided to a collection of machine learning feature selection models to identify focused probe sets that differentiate between sepsis and SIRS. These probe sets were combined to find an optimal probe set (UrSepsisModel) and calculate a urinary sepsis score (UrSepsisScore), which is the geometric mean of downregulated genes subtracted from the geometric mean of upregulated genes. This approach summarizes the expression values of all decisive genes as a single sepsis score. The UrSepsisModel and UrSepsisScore achieved area under the receiver operating characteristic curves 0.91 (95% confidence interval, 0.86–0.96) and 0.80 (95% confidence interval, 0.70–0.88) on the validation cohort, respectively. Functional analyses of probes associated with sepsis demonstrated metabolic dysregulation manifest as reduced oxidative phosphorylation, decreased amino acid metabolism, and decreased oxidation of lipids and fatty acids. Conclusions: Whole-genome transcriptomic profiling of urinary cells revealed focused probe panels that can function as an early diagnostic tool for differentiating sepsis from sterile SIRS. Functional analysis of differentially expressed genes demonstrated a distinct metabolic dysregulation signature in sepsis.
De novo putative loss‐of‐function variants in TAF4 are associated with a neuro‐developmental disorder

TATA‐binding protein associated factor 4 (TAF4) is a subunit of the Transcription Factor IID (TFIID) complex, a central player in transcription initiation. Other members of this multimeric complex have been implicated previously as monogenic disease genes in human developmental disorders. TAF4 has not been described to date as a monogenic disease gene. We here present a cohort of eight individuals, each carrying de novo putative loss‐of‐function (pLoF) variants in TAF4 and expressing phenotypes consistent with a neuro‐developmental disorder (NDD). Common features include intellectual disability, abnormal behavior, and facial dysmorphisms. We propose TAF4 as a novel dominant disease gene for NDD, and coin this novel disorder “TAF4‐related NDD” (T4NDD). We place T4NDD in the context of other disorders related to TFIID subunits, revealing shared features of T4NDD with other TAF‐opathies.
lncKRT16P6 promotes tongue squamous cell carcinoma progression by sponging miR-3180 and regulating GATAD2A expression

Tongue squamous cell carcinoma (TSCC) is characterized by a poor prognosis and its 5-year overall survival rate has not improved significantly. However, the precise molecular mechanisms underlying TSCC remain largely unknown. Through RNA screening, the present study identified a novel long noncoding RNA (lncRNA), keratin 16 pseudogene 6 (lncKRT16P6), which was upregulated in TSCC tissues and cell lines and associated with TSCC tumor stage and differentiation grade. Inhibition of lncKRT16P6 expression reduced TSCC cell migration, invasion and proliferation. lncKRT16P6 sponged microRNA (miR)-3180 and upregulated GATA zinc finger domain containing 2A (GATAD2A) expression. miR-3180 inhibition reversed the lncKRT16P6 depletion-induced attenuation of TSCC malignancy and GATAD2A depletion reversed the miR-3180 silencing-induced enhancement of TSCC malignancy. In summary, the present study revealed a potential competitive endogenous RNA (ceRNA) regulatory pathway in which lncKRT16P6 modulates GATAD2A expression by binding miR-3180, ultimately promoting tumorigenesis and metastasis in TSCC. Therefore, lncKRT16P6 may be used as a prognostic biomarker and therapeutic target for clinical intervention in TSCC.
Diversity of Parengyodontium spp. strains isolated from the cultural heritage environment: Phylogenetic diversity, phenotypical diversity, and occurrence

ABSTRACT Parengyodontium album is a fungal species that frequently occurs in the cultural heritage environment. Although three subclades were initially described in the species, no study has sought to determine the occurrence of each subclade in the cultural heritage context. These subclades are easily distinguishable phylogenetically, but their morphological identification is more difficult. Eighteen strains isolated from different cultural sites and initially identified as P. album were studied phylogenetically, morphologically, and in terms of their susceptibility to econazole nitrate 0.2%, an antifungal product used as preservation treatment in cultural heritage domain. The phylogenetic study revealed that all studied strains belonged to P. album subclade 1 or P. torokii (P. album subclade 3) and none belonged to P. album subclade 2. The morphological study revealed the best characteristics to differentiate the three subclades/species, namely, the ability of the strains to grow at 32 C and 35 C on potato dextrose agar (PDA) medium and the shape of conidia. Finally, the strains displayed variable susceptibilities to econazole nitrate, with no apparent link to any particular subclade/species.
A Gauge Condition for Studying the Origin of Intrinsic Magnetospheres

We propose an analytical model based on the solution of the magnetohydrodynamics (MHD) equations for studying the origin of intrinsic magnetospheres. For this purpose, we reveal a new gauge condition for the electromagnetic vector potential, which eases the solution of such complex system of non-linear equations. Using this model, we analyse the deformation of the terrestrial magnetic field due to the presence of the solar wind. By comparing with experimental observations, we have found that the geometrical configuration of the magnetosphere, before, and after the magnetic field of the Earth started to deviate the solar wind, has not changed notably, and that the solar wind should have had a finite conductivity. This model can also be used to perform linear stability analysis of fluid and magnetic instabilities.
Spatial Correlation Between Myocyte's Repolarization Times and Their Alternans Drives T-Wave Alternans on the ECG

Objective: T-wave alternans (TWA) manifests as beat-to-beat fluctuations of T-wave morphology on the electrocardiogram (ECG), with physiological bases not fully understood. Using a biophysical model of the ECG, we demonstrate and give explicit relations that TWA depends on the i) spatial covariance between myocytes' repolarization time and alternans; and ii) global alternans (common to every myocyte). Methods: We quantified the spatial covariance and global alternans by means of two new metrics, <inline-formula><tex-math notation="LaTeX">$\mathcal {R}$</tex-math></inline-formula> index and <inline-formula><tex-math notation="LaTeX">$\bar{\delta }$</tex-math></inline-formula>, respectively. They were validated on both synthetic and real signals. Computerized simulations were generated using a biophysical model linking the action potentials with the surface ECG. Then, the metrics were computed in STAFF-III dataset, containing ECGs from patients who underwent coronary angioplasty with prolonged balloon inflations, and the time courses of the metrics were analyzed together with TWA measured on the surface ECG. Results: The metrics properly estimated the spatial covariance and global alternans in the synthetic data. In the STAFF-III dataset, the <inline-formula><tex-math notation="LaTeX">$\mathcal {R}$</tex-math></inline-formula> index progressively increased from baseline to the fourth minute of inflation (median <inline-formula><tex-math notation="LaTeX">$\Delta \mathcal {R}=0.81$</tex-math></inline-formula> ms; p<inline-formula><tex-math notation="LaTeX">$< $</tex-math></inline-formula>0.05), whereas <inline-formula><tex-math notation="LaTeX">$\bar{\delta }$</tex-math></inline-formula> was mostly unaltered during the intervention (<inline-formula><tex-math notation="LaTeX">$\bar{\delta }=0$</tex-math></inline-formula> ms). Conclusion: We reported, for the first time, that TWA is significantly driven by the myocyte's spatial covariance between their repolarization times and alternans, and not by global alternans, when TWA is generated by regional ischemia. Significance: The metrics may reveal new complementary insights into the mechanisms underlying TWA.
Initiator tRNA lacking 1-methyladenosine is targeted by the rapid tRNA decay pathway in evolutionarily distant yeast species

All tRNAs have numerous modifications, lack of which often results in growth defects in the budding yeast Saccharomyces cerevisiae and neurological or other disorders in humans. In S. cerevisiae, lack of tRNA body modifications can lead to impaired tRNA stability and decay of a subset of the hypomodified tRNAs. Mutants lacking 7-methylguanosine at G46 (m7G46), N2,N2-dimethylguanosine (m2,2G26), or 4-acetylcytidine (ac4C12), in combination with other body modification mutants, target certain mature hypomodified tRNAs to the rapid tRNA decay (RTD) pathway, catalyzed by 5’-3’ exonucleases Xrn1 and Rat1, and regulated by Met22. The RTD pathway is conserved in the phylogenetically distant fission yeast Schizosaccharomyces pombe for mutants lacking m7G46. In contrast, S. cerevisiae trm6/gcd10 mutants with reduced 1-methyladenosine (m1A58) specifically target pre-tRNAiMet(CAU) to the nuclear surveillance pathway for 3’-5’ exonucleolytic decay by the TRAMP complex and nuclear exosome. We show here that the RTD pathway has an unexpected major role in the biology of m1A58 and tRNAiMet(CAU) in both S. pombe and S. cerevisiae. We find that S. pombe trm6Δ mutants lacking m1A58 are temperature sensitive due to decay of tRNAiMet(CAU) by the RTD pathway. Thus, trm6Δ mutants had reduced levels of tRNAiMet(CAU) and not of eight other tested tRNAs, overexpression of tRNAiMet(CAU) restored growth, and spontaneous suppressors that restored tRNAiMet(CAU) levels had mutations in dhp1/RAT1 or tol1/MET22. In addition, deletion of cid14/TRF4 in the nuclear surveillance pathway did not restore growth. Furthermore, re-examination of S. cerevisiae trm6 mutants revealed a major role of the RTD pathway in maintaining tRNAiMet(CAU) levels, in addition to the known role of the nuclear surveillance pathway. These findings provide evidence for the importance of m1A58 in the biology of tRNAiMet(CAU) throughout eukaryotes, and fuel speculation that the RTD pathway has a major role in quality control of body modification mutants throughout fungi and other eukaryotes.
Supersonic downflows in the vicinity of a growing pore. Evidence of unresolved magnetic fine structu

Aims. The velocity and magnetic fine structure of the chromosphere at the leg of an emerging magnetic loop is investigated at a location of supersonic downflows. Methods. We analyze a time series of spectropolarimetric data in the Hei 1083 nm triplet covering a time interval of≈70 minutes. The temporal evolution as well as the topology of the magnetic field in the downflow region are investigated. We apply an inv ersion technique based on a genetic algorithm using the Milne-Eddington approach. The technique is very reliable and robust in retrieving maps of the velocity and the magnetic field vector for both atm ospheric components separately. Results. We observe redshifts corresponding to a downflow speed of up t o 40 km s −1 in the vicinity of a growing pore. These supersonic downflows always coexist with a second atmospheric com ponent almost at rest (slow component) within the same resolution element. The redshifted component is more inclined to the solar normal than the slow component and has a different field strength. Conclusions. We interpret this downflow as a consequence of the draining of the rising loops. The different magnetic field orientation of the redshifted and the slow component give rise to two possible interpretations: an uncombed structure of the chromosphere, similar to the differently inclined flux-tubes in the penumbra of a sunspot, or a cloud-like structure containing gas at different velocities in two separate height layers of the solar atmosphere.
Segmentación de imágenes en viñedos para la medición autónoma de variables vitícolas

Resumen En el presente trabajo se ofrece un estudio experimental para segmentacion de madera sobre imagenes de vinedos en condiciones realistas de clima e iluminacion. Los resultados son muy alentadores y se presenta la medicion del diametro de tronco en las vides fotografiadas como un caso de uso real. Se consideran tres tecnoloǵias de segmentacion: K-means, Gaussian Mixture y Support Vector Machines. Ademas de diametro de tronco se exponen otros casos en donde nuestro enfoque es potencialmente util dentro del contexto de Viticultura de Precision.