Miracle-dz/UniFAR-FTUs huggingface dataset:
English translation of the first study reporting cyclical periods of increased respiration and eye and body motility during sleep in infants in 1926, with commentary

Abstract This is the first English translation of the work Periodic phenomena in the sleep in children, published in 1926 in the Journal Novoe v refleksologii i fiziologii nervnoi sistemy (Vol. 2, pp. 338–345) by Maria Denisova and Nicholai Figurin; it is the first study to report data on what is currently termed rapid eye movement (REM) sleep. The authors acquired continuous quantitative respiration data, as well as, eye and body movements during sleep in children for up to 6 hours, and discovered several novel features of sleep cycles in healthy infants from birth to about 1 year of age. First, the study reports cyclical periods of increased respiration and eye and body movements, with rapid ocular movements visible under relaxed eyelids (separation: 0.5–1 mm). These observations suggest atonia of REM sleep. Second, the length of the complete cycle (alternating active and quiet sleep phases or states) is about 50 minutes, an estimate that is consistent with later work. Third, the study identifies infant-specific ordering of sleep states, with the active phase beginning after sleep onset, followed by the quiescence phase. Importantly, these published data on sleep cycles precede all published studies related to the state now termed REM sleep by about 30 years (i.e. publishing in Science and in the Journal of Applied Physiology in the 1950s by Eugene Aserinski and Nathaniel Kleitman). In the historical commentary accompanying this translation, the findings of those later works are carefully compared to the original data on respiration and ocular and body motility cycles during sleep in infants, first reported and published by Denisova and Figurin (1926).
Sarcopenia assessed by computed tomography or magnetic resonance imaging is associated with the loss of response to biologic therapies in adult patients with Crohn's disease

Sarcopenia occurs in patients with Crohn's disease (CD). However, the association between sarcopenia and loss of response (LOR) to biologic agents remains unclear. This study explored such an association in CD patients. This retrospective study included 94 CD patients who received biologic therapy. The skeletal muscle cross‐sectional area at the third lumbar was assessed by computed tomography or magnetic resonance imaging for sarcopenia evaluation. A LOR was defined by fecal calprotectin (FC) < 250 μg/g or >50% reduction from baseline levels or other factors, such as the used agent being replaced by other biologic agents. The association between sarcopenia and LOR was assessed by logistic regression analysis. LOR was observed in 54 patients (57.4%). The prevalence of sarcopenia in the LOR group was higher than that in response group (70.4% vs. 40.0%, p = 0.003). Sarcopenia (odds ratio [OR] = 3.89, 95% confidence interval [CI]: 1.31–11.54), Montreal L1 type (OR = 0.20, 95% CI: 0.06–0.60), perianal lesions (OR = 4.08, 95% CI: 1.31–12.70), and monocytes percentage (OR = 1.27, 95% CI: 1.02–1.57) at baseline were independent associated factors for LOR. Sarcopenia was also associated with LOR in patients who received infliximab (OR = 3.31, 95% CI: 1.11–9.87). Montreal L1 type, perianal lesions, and monocytes percentage (Model 1), and with additional consideration of sarcopenia (Model 2), were developed to predict LOR. Model 2 showed better performance than Model 1 (area under the curve [AUC] 0.82 vs. 0.75). Sarcopenia was associated with the LOR to biological agents or infliximab in adult patients with CD.
Evaluation of the Diagnostic Value of Oesophageal Biopsies for Direct Immunofluorescence Microscopy in Mucous Membrane Pemphigoid

Mucous membrane pemphigoid is an autoimmune blistering disorder characterized by predominant involvement of surface-close epithelia and linear depositions of immunoreactants at the dermal-epithelial junction on direct immunofluorescence microscopy. A major diagnostic difficulty is the frequent need for multiple biopsies to facilitate the diagnosis. Although oesophageal involvement is a rare, but life-threatening manifestation, the relevance of oesophageal direct immunofluorescence sampling is unclear. This retrospective monocentric study evaluated 67 non-lesional biopsies from 11 patients with mucous membrane pemphigoid and clinical symptoms suggestive of oesophageal involvement, comprising 31 samples from the oesophagus and 36 samples from other anatomical sites. Five patients (45.5%) exhibited endoscopic findings compatible with oesophageal involvement of mucous membrane pemphigoid. No correlation was identified between the presence of oesophageal lesions and direct immunofluorescence positivity in lesions from the oesophagus (p = 1.0). Oral and cutaneous samples were significantly more frequently positive by direct immunofluorescence than were oesophageal biopsies (p < 0.0001 and p = 0.0195, respectively). Oesophageal samples yielded significantly less IgG reactivity than oral and cutaneous lesions (p < 0.0001 and p = 0.0126, respectively), and less IgA antibody response than oral lesions (p = 0.0036). In conclusion, oesophageal direct immunofluorescence samples were inferior to oral and cutaneous biopsies for the diagnosis of mucous membrane pemphigoid even when oesophageal lesions compatible with mucous membrane pemphigoid were present at the time of biopsy. SIGNIFICANCE The diagnostic gold standard for mucous membrane pemphigoid, a potentially fatal autoimmune blistering disease, is direct immunofluorescence microscopy of a perilesional biopsy. The aim of this study was to assess the diagnostic accuracy and clinical-immunopathological correlations of biopsies obtained from the oesophagus, as its epithelium represents a possible target of autoantibodies in mucous membrane pemphigoid. The results suggest that findings from direct immunofluorescence microscopy of oesophageal biopsies do not correlate with endoscopic findings and symptoms indicative for oesophageal involvement. Thus, these data favour oral or cutaneous perilesional biopsies for direct immunofluorescence microscopy even in the presence of oesophageal lesions and/or symptoms compatible with mucous membrane pemphigoid.
Cost-effectiveness of Low-complexity Screening Tests in Community-based Case-finding for Tuberculosis

Abstract Introduction In high-burden settings, low-complexity screening tests for tuberculosis (TB) could expand the reach of community-based case-finding efforts. The potential costs and cost-effectiveness of approaches incorporating these tests are poorly understood. Methods We developed a microsimulation model assessing 3 approaches to community-based case-finding in hypothetical populations (India-, South Africa-, The Philippines-, Uganda-, and Vietnam-like settings) with TB prevalence 4 times that of national estimates: (1) screening with a point-of-care C-reactive protein (CRP) test, (2) screening with a more sensitive “Hypothetical Screening test” (95% sensitive for Xpert Ultra-positive TB, 70% specificity; equipment/labor costs similar to Xpert Ultra, but using a $2 cartridge) followed by sputum Xpert Ultra if positive, or (3) testing all individuals with sputum Xpert Ultra. Costs are expressed in 2023 US dollars and include treatment costs. Results Universal Xpert Ultra was estimated to cost a mean $4.0 million (95% uncertainty range: $3.5 to $4.6 million) and avert 3200 (2600 to 3900) TB-related disability-adjusted life years (DALYs) per 100 000 people screened ($670 [The Philippines] to $2000 [Vietnam] per DALY averted). CRP was projected to cost $550 (The Philippines) to $1500 (Vietnam) per DALY averted but with 44% fewer DALYs averted. The Hypothetical Screening test showed minimal benefit compared to universal Xpert Ultra, but if specificity were improved to 95% and per-test cost to $4.5 (all-inclusive), this strategy could cost $390 (The Philippines) to $940 (Vietnam) per DALY averted. Conclusions Screening tests can meaningfully improve the cost-effectiveness of community-based case-finding for TB but only if they are sensitive, specific, and inexpensive.
Estimating plume reach and trapping radii for male and female Cydia pomonella (Lepidoptera:Tortricidae) captured in pheromone–kairomone baited traps in Washington State apple orchards under mating disruption

Male Cydia pomonella (L.) (Lepidoptera:Tortricidae) dispersion has largely been studied in nonmating disrupted orchards due to synthetic pheromone interference with capture in monitoring traps. Little is known about female dispersion. This study aimed to characterize male and female dispersion in mating disrupted commercial apple orchards. Sterile C. pomonella recapture data from single-trap multiple-release experiments using PHEROCON CM-DA COMBO + AA Lure-baited orange Pherocon VI delta traps was interpreted to determine pheromone–kairomone lure-baited trap effective area, trap deployment density for effective monitoring, and absolute male and female C. pomonella density in mating disrupted Washington commercial apple orchards. The maximum plume reach of the pheromone–kairomone lure in mating disrupted orchards was <5 m from the baited trap for both sexes. Maximum dispersive distances for 95% of the released C. pomonella in mating disrupted orchards were 106 and 135 m for males and females, yielding trapping areas of 3.87 and 6.16 ha, respectively. Estimates were consistent across 3 growing seasons and represent the first records of male and female dispersal distance and monitoring trap efficacy from commercial C. pomonella mating disrupted apple orchards. With relevance to commercial monitoring programs and economic thresholds in mating disrupted orchards, traps should be deployed at a density of 1 per 3–6 ha. Capture of a single male or female C. pomonella corresponds to at least 82–104 C. pomonella within the 3–6 ha trapping area. This refined C. pomonella capture interpretation in pheromone–kairomone baited traps in mating disrupted commercial apple orchards yields more precise damage estimates and assists in insecticide-use decision making.
Tool kits in regional science : theory, models, and estimation

Complex Socio-Economic Systems in Regional Science. - New Developments in Input-Output Analysis. - Interregional Computable General Equilibrium Models. - Optimality Versus Stability: Pattern Formation in Spatial Economics. - Urban and Hinterland Evolution Under Growing Population Pressure. - Socio-Spatial Dynamics and Discrete Non-Linear Probabilistic Chains. - Principles of Neural Spatial Interaction Modeling. - Quick but not so Dirty ML Estimation of Spatial Autoregressive Models. - Innovation Diffusion Theory: 100 Years of Development. - Urban Economics at a Cross-Road. - Conclusion.
A novel EGFR variant EGFRx maintains glioblastoma stem cells through STAT5.

BACKGROUND Glioblastomas are universally lethal brain tumors containing tumor-propagating glioblastoma stem cells (GSCs). EGFR gene amplification or mutation is frequently detected in GBMs and is associated with poor prognosis. However, EGFR variants in GSCs and their role in the maintenance of GSCs and progression of GBM are unclear. METHODS EGFR variants were detected through bioinformatic HISAT-StringTie-Ballgown pipeline and verified through 5' RACE, RT-PCR, ribonuclease protection, and northern blotting assays. EGFRx function was investigated through neurosphere, cell viability, intracranial xenograft and RNA-seq assays. EGFRx-STAT5 signaling was investigated through western blotting, coimmunoprecipitation, immunofluorescence, luciferase reporter, RT-PCR and CUT&Tag assays. RESULTS We identified a novel EGFR variant (EGFRx), that is specifically expressed in GSCs. Unlike the EGFRvIII variant, which lacks exons 2-7, EGFRx is characterized by the absence of exons 2-14, and encodes an EGFR protein that does not possess the entire extracellular ligand-binding domain. We observed that EGFRx exhibits significant glycosylation, is required for GSC self-renewal, proliferation, and tumorigenesis, and highly active in glioblastomas compared to normal brain tissue. Mechanistically, EGFRx constitutively and specifically activates STAT5 in GSCs through spontaneous asymmetric dimerization of the kinase domain. CONCLUSIONS EGFRx plays essential roles in the maintenance of the GSC phenotype through constitutive activation of STAT5 and promotes GBM progression, suggesting that EGFRx-STAT5 signaling represents a promising therapeutic target for GBM.
Probe Beam Dichroism and Birefringence in Stimulated Raman Scattering in Polyatomic Molecules.

Dichroism and birefringence in Stimulated Raman Scattering (SRS) in polyatomic molecules were studied theoretically. General expressions describing the change of the polarization matrix of the probe laser beam transmitted through initially isotropic molecular sample excited by the pump laser beam have been derived. Arbitrary polarization states and propagation directions of the incoming pump and probe beams were considered. The expressions were written in terms of spherical tensor operators that allowed for separation of the field polarization tensor and the molecular part containing three scalar values of nonlinear optical susceptibility χ(3)Kpu with Kpu = 0,1,2. The geometry of almost collinear propagation of the pump and probe beams through the molecular sample was considered in greater details. It was shown that the dichroism and birefringence refer to the nonlinear optical susceptibility element χ(3)2 and that their contributions to the SRS signal can be separated experimentally by using an appropriate probe beam polarization analyzer installed in front of the photodetector. Particular cases of the off-resonant SRS and resonant SRS have been considered. The results obtained were expressed in terms of the Stokes polarization parameters of the pump and probe beams.
Environmental Hazards and Disasters: Contexts, Perspectives and Management

Disasters undermine societal well-being, causing loss of lives and damage to social and economic infrastructures. Disaster resilience is central to achieving the 2030 Sustainable Development Goals, especially in regions where extreme inequality combines with the increasing frequency and intensity of natural disasters. Disaster risk reduction and resilience requires participation of wide array of stakeholders ranging from academicians to policy makers to disaster managers. Disaster Resilient Cities: Adaptation for Sustainable Development offers evidence-based, problem-solving techniques from social, natural, engineering and other disciplinary perspectives. It connects data, research, conceptual work with practical cases on disaster risk management, capturing the multi-sectoral aspects of disaster resilience, adaptation strategy and sustainability. The book links disaster risk management with sustainable development under a common umbrella, showing that effective disaster resilience strategies and practices lead to achieving broader sustainable development goals. Provides foundational knowledge on integrated disaster risk reduction and management to show how resilience and its associated concept such as adaptive and transformative strategies can foster sustainable development Brings together disaster risk reduction and resilience scientists, policy-makers and practitioners from different disciplines Case studies on disaster risk management from natural science, social science, engineering and other relevant disciplinary perspectives
Strigolactones promote plant freezing tolerance by releasing the WRKY41‐mediated inhibition of CBF/DREB1 expression

Cold stress is a major abiotic stress that adversely affects plant growth and crop productivity. The C‐REPEAT BINDING FACTOR/DRE BINDING FACTOR 1 (CBF/DREB1) transcriptional regulatory cascade plays a key role in regulating cold acclimation and freezing tolerance in Arabidopsis (Arabidopsis thaliana). Here, we show that max (more axillary growth) mutants deficient in strigolactone biosynthesis and signaling display hypersensitivity to freezing stress. Exogenous application of GR245DS, a strigolactone analog, enhances freezing tolerance in wild‐type plants and strigolactone‐deficient mutants and promotes the cold‐induced expression of CBF genes. Biochemical analysis showed that the transcription factor WRKY41 serves as a substrate for the F‐box E3 ligase MAX2. WRKY41 directly binds to the W‐box in the promoters of CBF genes and represses their expression, negatively regulating cold acclimation and freezing tolerance. MAX2 ubiquitinates WRKY41, thus marking it for cold‐induced degradation and thereby alleviating the repression of CBF expression. In addition, SL‐mediated degradation of SMXLs also contributes to enhanced plant freezing tolerance by promoting anthocyanin biosynthesis. Taken together, our study reveals the molecular mechanism underlying strigolactones promote the cold stress response in Arabidopsis.
Critical assessment of protein intrinsic disorder prediction (CAID) ‐ Results of round 2

Protein intrinsic disorder (ID) is a complex and context‐dependent phenomenon that covers a continuum between fully disordered states and folded states with long dynamic regions. The lack of a ground truth that fits all ID flavors and the potential for order‐to‐disorder transitions depending on specific conditions makes ID prediction challenging. The CAID2 challenge aimed to evaluate the performance of different prediction methods across different benchmarks, leveraging the annotation provided by the DisProt database, which stores the coordinates of ID regions when there is experimental evidence in the literature. The CAID2 challenge demonstrated varying performance of different prediction methods across different benchmarks, highlighting the need for continued development of more versatile and efficient prediction software. Depending on the application, researchers may need to balance performance with execution time when selecting a predictor. Methods based on AlphaFold2 seem to be good ID predictors but they are better at detecting absence of order rather than ID regions as defined in DisProt. The CAID2 predictors can be freely used through the CAID Prediction Portal, and CAID has been integrated into OpenEBench, which will become the official platform for running future CAID challenges.
The Dragon Millennium: Chinese Business in the Coming World Economy

Introduction Economic Policy and the Development of the Firm Chinese State-Owned Enterprises under the Dual Influence of the Government and the Market by David Li The Evolutions of Chinese Township and Village Enterprises by Qi Hantang The Future of Private Enterprises in China by Wang Xueli Outlook on Selected Industries The Structure and Development of China's Financial Markets by Chen Baizhu and Feng Yi Different Behaviors of Chinese Auto Makers in Technology Introduction and Assimilation by Chen Jin The Oil Dragon's Move: What It Means for China and the World by Xu Xiaojie and Deng Shengliang China Ascendant: Competition, Cooperation, and Capitalism Challenges of Competing in China for Multinationals by Edward Tse Project and Location Selection in China: Lessons for Foreign Companies by Luo Yadong The Internationalization of Chinese Enterprises: Evidence from the United Kingdom by Lu Tong The Lure of Chinese Management Chinese Small Business Management: A Tentative Theory by Siu Wai-Sum Raising the Dragon: Adaptive Entrepreneurship and Chinese Economic Development by Cheah Hock Beng Developing Virtuous Corporations with Chinese Characteristics for the 21st Century by Ip Po-Keung Index
Från feodalism till kapitalism skatternas roll i det svenska samhällets omvandling 1720-1910

Skatterna har spelat en avgorande roll i alla historiska samhallen, dar detfunnits en statsmakt. Deras utformning och betydelse i Sverige fran 1700-talets till 1900-talets borjan diskuteras i denna skrift. Under den behandladeperioden genomgick det svenska samhallet stora forandringar som starktpaverkade skatternas utformning och deras ekonomiska och politiska innebord. I skriften diskuterar de bagge forfattarna skatteforandringarna ur historieteoretiskaaspekter. Fragan om deras samband med samhallsutvecklingenbehandlas ur ett overgripande historiematerialistiskt perspektiv, varvid forandringarnai statens funktioner agnas sarskild uppmarksamhet. Dareftervisar Kekke Stadin hur overgangen fran feodalism till kapitalism i Sverige paverkadebeskattningen av en sektor i naringslivet, dar den stora samhallsomvandlingenrelativt tidigt fick patagliga foljder, namligen sagverksnaringen. Hur och varfor de gamla grundskatterna avskaffades och de nya progressivaskatterna infordes omkring sekelskiftet 1900 ar temat for Stellan Dahlgrensframstallning i skriftens tredje och sista huvudavsnitt.
Detection of locally adapted genomic regions in wild rice (Oryza rufipogon) using environmental association analysis

Abstract Oryza rufipogon is the wild progenitor of cultivated rice Oryza sativa and exhibits high levels of genetic diversity across its distribution, making it a useful resource for the identification of abiotic stress–tolerant varieties and genes that could limit future climate-changed–induced yield losses. To investigate local adaptation in O. rufipogon, we analyzed single nucleotide polymorphism (SNP) data from a panel of 286 samples located across a diverse range of climates. Environmental association analysis (EAA), a genome-wide association study (GWAS)-based method, was used and revealed 15 regions of the genome significantly associated with various climate factors. Genes within these environmentally associated regions have putative functions in abiotic stress response, phytohormone signaling, and the control of flowering time. This provides an insight into potential local adaptation in O. rufipogon and reveals possible locally adaptive genes that may provide opportunities for breeding novel rice varieties with climate change–resilient phenotypes.
Recent advances in pyroptosis, liver disease, and traditional Chinese medicine: A review

In recent years, the incidence of liver disease has increased, becoming a major cause of death. Various liver diseases are intricately linked to pyroptosis, which is one of the most common forms of programmed cell death. As a powerful weapon in the fight against liver diseases, traditional Chinese medicine (TCM) can affect pyroptosis via a number of routes, including the classical, nucleotide oligomerization domain‐like receptors protein 3/caspase‐1/gasdermin D (GSDMD) pathway, the nonclassical lipopolysaccharide/caspase‐11/GSDMD pathway, the ROS/caspase‐3/gasdermin E pathway, the caspase‐9/caspase‐3/GSDMD pathway, and the Apaf‐1/caspase‐11/caspase‐3 pathway. In this review, we provide an overview of pyroptosis, the interplay between pyroptosis and liver diseases, and the mechanisms through which TCM regulates pyroptosis in liver diseases. The information used in the text was collected and compiled from the databases of PubMed, Web of Science, Scopus, CNKI, and Wanfang Data up to June 2023. The search was not limited with regard to the language and country of the articles. Research and review articles were included, and papers with duplicate results or unrelated content were excluded. We examined the current understanding of the relationship between pyroptosis and liver diseases as well as the advances in TCM interventions to provide a resource for the identification of potential targets for TCM in the treatment of liver diseases.