Miracle-dz/UniFAR-FTUs huggingface dataset:
THE CONTINUUM RANDOM TREE. I1

Exact and asymptotic results for the uniform random labelled tree on n vertices have been studied extensively by combinatorialists. Here we treat asymptotics from a modern stochastic process viewpoint. There are three limit processes. One is an infinite discrete tree. The other two are most naturally represented as continuous two-dimensional fractal tree-like subsets of the infinite-dimensional space 11. One is compact; the other is unbounded and self-similar. The proofs are based upon a simple algorithm for generating the finite random tree and upon weak convergence arguments. Distributional properties of these limit processes will be discussed in a sequel.
Contributions à l'analyse non linéaire : équations différentielles à variable convexe : viabilité à l'ordre deux

La premiere partie de cette these est consacree au probleme suivant : soit une convexe compact qui se deforme avec le temps suivant une loi de type differentiel, comment interpreter ce phenomene en terme de solution d'une equation differentielle ou la variable d'etat serait une convexe compact ? Ce type de probleme apparait, par exemple, en controle optimal ou dans l'etude des ensembles atteignables d'une inclusion differentielle. On precisera ici les notions de differentielles d'une multi application et de champs de vecteurs sur l'ensemble des convexes compacts et on donnera un resultat d'existence. On etudiera surtout les champs de vecteurs construits avec une nouvelle operation (dite de convolution) sur les convexes compacts, liee au groupe des rotations en dimension finie. La deuxieme partie traite de la viabilite d'un ferme pour une inclusion differentielle du second ordre. Il s'agit d'etablir des conditions d'existence de solutions qui demeurent localement dans le ferme. La construction de solutions passe par l'etude du fibre tangent de ce ferme, a travers deux approches : a) la notion d'admissibilite sur le fibre tangent (avec S. Gautier, R. Morchadi) b) l'introduction d'une fonction speciale sur ce fibre. On evite ainsi les hypotheses fortes sur le fibre tangent donnees par Cornet-Haddad ou Auslender-Mechler.
2013 Weymann i inni ANG tp rec rec

This paper presents the methodology and results of comparative tests of tractor engine emission powere d by diesel and two types of biofuels: rapeseed oil methyl esters and c amelina oil methyl esters. Measurements of the CO 2 emissions, toxic exhaust gas components (CO, HC, NO x) and mass, quantity, size of particulate matter (P M) are also included.
Growth hormone-induced phosphorylation of EGF receptor in 3T3-F442A cells: modulation of EGF-induced trafficking and signaling

ERK activation in regulating the trafficking itinerary of the EGF-stimulated EGFR. Finally, we observed augmentation of early aspects of EGF signaling (EGF-induced ERK2 activation and EGF-induced Cbl tyrosine phosphorylation) by GH cotreatment; the GH effect on EGF-induced Cbl tyrosine phosphorylation was also prevented by MEK1 inhibition. These data indicate that GH, by activating ERKs, can modulate EGF-induced EGFR trafficking and signaling and expand our understanding of mechanisms of crosstalk between the GH and EGF signaling systems. both does intrinsic tyrosine activation, slows rate of EGF-induced and EGF-induced EGFR These results suggest that GH may affect EGF signaling of EGFR trafficking.
Tumor Necrosis Factor- (cid:1) -Induced Cytokine-Induced Neutrophil Chemoattractant-1 (CINC-1) Production by Rat Gastric Epithelial Cells: Role of Reactive Oxygen Species and Nuclear Factor- (cid:2) B

Rat cytokine-induced neutrophil chemoattractant-1 (CINC-1), a counterpart of the human growth-regulated oncogene product (GRO), has been suggested to participate in neutrophil recruit- ment in an experimental model of gastritis in rat. However, the mechanism(s) involved in regulation of CINC-1 production by the gastric mucosa remains unclear. The aim of this study was to investigate the mechanism(s) of CINC-1 production by rat gastric mucosa in vitro. All experiments were performed using rat normal gastric mucosal cell line (RGM-1). RGM-1s were stimulated with tumor necrosis factor (TNF)- (cid:1) , and CINC-1 mRNA levels (reverse transcription-polymerase chain reaction) and protein
Migrational Adaptation and Current Diabetes and Overall Mortality among Various United States and Worldwide Races/Ethnicities

Out of Africa migrations ~60,000 years ago led to widespread populating of Earth. Ancient migration distances appear related to medical observations including diabetic risk alleles and altitude adaptation. Our objective is to show that ancient migration distance is related to current survival. We measured migration distances and correlated these with diabetes and other US mortality rates and international life expectancy among various racial/ethnic groups. For diabetes there are strong, negative correlations with US mortality rates of ethnic groups and migration distance (r= - 0.70, p< 0.00059), which are confirmed using overall US mortality rates (r=-0.84, p<1x10 5 ). There is further confirmation using cardiovascular mortality (r= - 0.86), cancer (r= - 0.71) and sepsis (r= - 0.73). A second data set, World Health Organization 2012 life expectancy data from 192 countries confirm the above US correlations showing a moderate, positive correlation with migration distance (r= 0.41, p < 3 x 10 -8 ). R 2 analysis indicates that 71% (95% CI=0.48-0.90) of the overall US mortality rate is related to migration distance. When evaluating worldwide life expectancy, migration distance retains 17% (95% CI=0.07-0.27) of its effect on survival. Our data are consistent with migrational adaptation being associated with enhanced US diabetes and other disease survivals for some ethnicities. There is superimposition of substantial influences of current healthy lifestyles/effective health care policies from life expectancy analyses. These interrelationships suggest the dimension of migrational adaptation be further evaluated in the demography of survival research and public health care policy.
Predictive analysis using resilient and traditional backpropagation algorithm

Artificial neural networks can be used in many applications like analysis, manipulation, predictions on the given statistical data. Neural-net is the function which is used to train the multi-layered perceptron when discussed about the regression analysis ,i.e to maximize the func-tional relationship between predictors(input variables) and the response variables(output). Hence neural networks can be used as an exten-sion of generalized linear models(supervised learning). This paper deals with the brief introduction about multi-layered perceptron and the validation of resilient backpropagation and the traditional backpropagation algorithms. A real time bank dataset is considered and predictions is being done on the Churning rates of Customers by the above two algorithms. It is observed that resilient backpropagation algorithm gives more accurate and precise results in comparison with traditional backpropagation algorithm by the number of steps taken by both the algorithms in convergence of the whole neural network and the error rate of both the algorithms.
DIAGNOSTIC VALUE OF PCR OF SALMONELLA ENTERICA SEROVAR ENTERITIDIS IN POULTRY AND HUMAN CONTACTS

A total of 110 chicken samples were collected randomly from naturally infected farms in Al-Rahmania district in Behera Province, Egypt where birds suffered from mottled liver with yellowish discoloration, distended gallbladder, slight air sacculitis, congested lungs and enlarged spleens. Liver, heart, spleen and cloacal swabs from chickens were sampled for isolation of Salmonella enterica serovar Enteritidis (SE). In addition, 50 human stool samples were collected from persons suffering from pyrexial illness with diarrhea and vomiting for several days hospitalized in areas surrounding examined poultry farms to be investigated for presence of SE by bacteriological examination. The obtained results of bacteriological examination revealed that Salmonella spp. were isolated from 4 out of 110 (3.63 %) of examined broiler chicken samples and 2 out of 50 (4 %) of examined stool samples. The serological identification of Salmonella isolates by using polyvalent and monovalent (O) and (H) Salmonella antisera clarified that 3 isolates from chicken isolates were proved to be SE and one isolate from human isolates was proved to be SE. At the same time, all positive samples were re-examined by using Polymerase chain reaction (PCR) where its result revealed that 4 isolates out of 6 were SE . The obtained results of the current work confirmed the diagnostic value of PCR detection of SE in poultry and surrounding people in which PCR is very sensitive, very specific and relatively rapid test.
Preconditioned Conjugate-Gradient Methods for Nonsymmetric Systems of Linear Equations.

Abstract : In this paper, we present a class of iterative descent methods for solving large, sparse, nonsymmetric systems of linear equations whose coefficient matrices have positive-definite symmetric parts. Such problems commonly arise from the discretization of non-self-adjoint elliptic partial differential equations. The methods we consider are modelled after the conjugate gradient method. They require no estimation of parameters and their rate of convergence appears to depend on the spectrum of A rather than ATA. Their convergence can also be accelerated by preconditioning techniques.
a copy of Prevalence of Panton-Valentine Leukocidin (PVL) and antimicrobial resistance in community-acquired clinical Staphylococcus aureus in an urban Gambian hospital : a 11-year period retrospective pilot study community-acquired

Background: Staphylococcus aureus is a major human pathogen. Panton-Valentine leukocidin (PVL) is a virulence factor produced by some strains that causes leukocyte lysis and tissue necrosis. PVL-associated S. aureus (PVL-SA) predominantly causes skin and soft-tissue infections (SSTIs) but can also cause invasive infections such as necrotizing pneumonia. It is carried by both community-associated methicillin susceptible S. aureus (CA-MSSA) and methicillin resistant S. aureus (CA-MRSA). This study aims to determine the prevalence of PVL-SA among patients seen at an urban Gambian hospital and associated antibiotic resistance. Methods: Archived clinical S. aureus (70 invasive bacteraemia and 223 non-invasive SSTIs) from 293 patients were retrieved as well as relevant data from clinical records where available. Antibiotic susceptibility was assessed using disc diffusion according to Clinical Laboratory Standards Institute (CLSI) guidelines. Genomic DNA was extracted and the presence of lukF and lukS PVL genes was detected by conventional gel-based PCR. Result: PVL-SA strains accounted for 61.4% (180/293) of S. aureus isolates. PVL prevalence was high in both Gambian bacteraemia and SSTIs S. aureus strains. Antimicrobial resistance was low and included chloramphenicol (4.8%), cefoxitin ciproﬂoxacin erythromycin gentamicin Conclusion: PVL expression is high among clinical S. aureus strains among Gambian patients. Reporting of PVL-SA clinical infections is necessary to enable the monitoring of the clinical impact of these strains in the population and guide prevention of the spread of virulent PVL-positive CA-MRSA strains. Staphylococcus aureus ( S. aureus ) is a major human pathogen with several virulence factors. We performed a retrospective analysis to investigate the prevalence of one such virulence factor (PVL) amongst clinical S. aureus samples. We found a high prevalence in our setting but antimicrobial resistance including methicillin resistance was low.
DDDT_A_275148 5077..5085

Department of Orthopedic Surgery, Xiang’an Hospital of Xiamen University, Xiamen City, Fujian, People’s Republic of China Purpose: The long-term survival rate of osteosarcoma, which is the most common type of primary malignant bone tumor, has stagnated in past decades. Acacetin is a natural flavonoid compound that has antioxidative and anti-inflammatory effects and exhibits extensive therapeutic effects on various cancers. In this study, the anticancer potential of acacetin and the underlying molecular mechanisms were examined in human osteosarcoma cells (SJSA and HOS). Materials and Methods: HOS and SJSA cell lines were exposed to different concentrations of acacetin. Cell proliferation and viability were assessed by CCK-8 and colonyformation assays. Hoechst 33258 fluorescent staining was employed to detect apoptosis. Cell apoptosis was measured by an annexin V-FITC/PI assay by flow cytometry. The alteration in the mitochondrial membrane potential was detected by a JC-1 Assay Kit. Apoptosis-related protein expression was determined by Western blotting. Intracellular reactive oxygen species (ROS) production was detected by fluorescence microscopy and flow cytometry. Subsequently, the activation of the ROS/JNK signaling pathway was investigated. Results: Acacetin could inhibit proliferation and induce apoptosis in SJSA and HOS cells. The acacetin treatment resulted in the activation of caspase-3, −8, and −9 and cleaved PARP. Further studies showed that acacetin-induced apoptosis was attributed to ROS. In addition, we found that acacetin induced the activation of the downstream c-Jun N-terminal kinase (JNK) signaling pathway. Subsequently, after treatment with the ROS scavenger GSH and the JNK inhibitor SP600125, the apoptosis-inducing effect triggered by acacetin was significantly attenuated. Conclusion: The results of the present study indicate that acacetin may induce apoptosis to inhibit cell growth by activating the ROS/JNK signaling pathway in SJSA and HOS cells, suggesting that acacetin may be a promising candidate for the management of osteosarcomas.
E ﬀ ect of Juvenile Hormone on Resistance against Entomopathogenic Fungus Metharizium robertsii Di ﬀ ers between Sexes

: Juvenile hormone has been suggested to be a potential mediator in the trade-o ﬀ between mating and insects’ immunity. Studies on various insect taxons have found that juvenile hormone interferes with humoral and cellular immunity. Although this was shown experimentally, studies using highly virulent parasites or pathogens are lacking so far. In this study, we tested if juvenile hormone administration a ﬀ ected resistance against entomopathogenic fungi, Metharizium robertsii , in the mealworm beetle, Tenebrio molitor . In previous studies with T. molitor, juvenile hormone has been found to reduce a major humoral immune e ﬀ ector-system (phenoloxidase) in both sexes and decrease the encapsulation response in males. Here, we found that juvenile hormone administration prolonged survival time after infection with M. robertsii in males but reduced survival time in females. This study indicates that the e ﬀ ects of juvenile hormone on insect immunity might be more complicated than previously considered. We also suggest that there might be a trade-o ﬀ between speciﬁc and non-speciﬁc immunity since, in males, juvenile hormone enhances speciﬁc immunity but corrupts non-speciﬁc immunity. Our study highlights the importance of using real parasites and pathogens in immuno-ecological studies.
APPLICATION OF SURPLUS PRODUCTION MODELS TO THE INDIAN OCEAN BIGEYE ( Thunnus obesus ) TUNA FISHERY

Surplus production models characterized by an increasing level of complexity were applied to the Indian Ocean bigeye tuna (Thunnus obesus) fishery to assess the current status of the stock and provide reference points to fishery managers. Data included catch rates standardised based on generalized linear models including several environmental and technical covariates to derive abundance indices for bigeye tuna on a 5- by 5 and 1- by 1 degree basis for 1960-2008 and 1980-2008, respectively. The results of the models were consistent in terms of diagnostic and suggested that the bigeye tuna stock would be close to a situation of MSY, with a biomass in 2008 comprised between 1.17-1.3 times the biomass at the maximum sustainable yield (MSY) and a fishing mortality in 2008 equal to 65-79% of the fishing mortality at MSY (F MSY ) for the base case runs. A sensitivity analysis performed to account for uncertainty in some input parameters and based on the 1980-2008 standardised CPUE time series showed that the results were quite robust to the parameter changes with F 2008 /F MSY and B 2008 /B MSY comprised between 0.7-0.84 and 1-1.28, respectively. The use of random walks on catchability showed a sharp shift upward in the abundance index time series in 1977-78 that could suggest a problem in the standardisation process linked to the implementation of deep longline in the late 1970s. Overall, the diagnostic and fisheries indicators derived from surplus production models were shown to be consistent with results derived in the course of the 2009 Working Party on Tropical Tunas from more complex models such as SS3 and ASPM.
Exact gravitational threshold correction in the Ferrara-Harvey-Strominger-Vafa model

We consider the automorphic forms which govern the gravitational threshold correction $F_1$ in models of heterotic/IIA duality with N=2 supersymmetry in four dimensions. In particular we derive the full nonperturbative formula for $F_1$ for the dual pair originally considered by Ferrara, Harvey, Strominger and Vafa (FHSV). The answer involves an interesting automorphic product constructed by Borcherds which is associated to the ``fake Monster Lie superalgebra. '' As an application of this result we rederive a result of Jorgenson & Todorov on determinants of $\bar \partial$ operators on $K3$ surfaces.
HYPOGLYCEMIC AND ANTIDIABETIC ACTIVITIES OF AQUEOUS EXTRACT OF PSEUDOLACHNOSTYLIS MAPROUNEIFOLIA VAR. MAPROUNEIFOLIA PAX (EUPHORBIACEAE) STEM BARK IN EXPERIMENTAL WISTAR RATS

The present scientific work was designed to investigate potential hypoglycaemic and antidiabetic activities of aqueous extract of Pseudolachnostylis maprouneifoilia var. maprouneifolia stem bark and its soluble fractions in experimental Wistar rats. Results indicated, in normal treated animals, at the highest oral dose of 600 mg/kg body weight, aqueous extract reached significant reduction of blood glucose to 68.5±0.1 mg/dl while its chloroform, ethylacetate, n- butanol and residual aqueous soluble fractions reduced blood glucose level from 81.5. ±0.2 to 77.2±0.1 mg/dl compared to untreated group (86.8±0.1 mg/dl, 0% reduction of blood glucose) after 180 min of observation. Glibenclamide reached until 66.6±0.3 mg/dl (23.88%) reduction of blood glucose These results indicated that samples of P. maprouneifolia var . maprouneifolia stem abrk and glibenclamide possess hypoglycaemic activity. On the other hand, the administration of aqueous extract and its fractions in treated diabetic Wistar rats at the highest oral dose of 600 mg/kg body weight causes significant reduction of glucose level ranging from 140.4 ±1.7 to 170.8±1.3 mg/dl compared to untreated diabetic animals with (202.7±0.3 mg/kg) after 180 min of observation. The observed concentration of glucose in diabetic rats after 180 min of observation was high and these animals were submitted to a particular treatment aiming the reduction of glucose level under 100 mg/dl. Thus, after 21 days of treatment, the aqueous extract and its fractions produced significant reduction of glucose level in treated diabetic animals ranging from 119.3±0.5 to 128.6 ±0.3 mg/dl at Day 21 and from 86.3±1.1 to 90.0±0.7 at Day 30 compared to untreated diabetic animals (248.3±0.2 and 257.6±0.3 mg/dl respectively) as a sign of their antidiabetic properties. These results demonstrated that these samples have hypoglycaemic and antidiabetic activities. In addition, aqueous extract showed good antihyperglycemic effect in treated animals. Glibenclamide used as a reference product exhibited high activities compared to the tested samples. These results constitute a scientific base supporting and justifying the use of P. maprounefolia var. maprouneifolia stem bark for the treatment of diabetes mellitus type 2 in traditional medicine in Democratic Republic of Congo and other African countries where it is found.
Correlation Between Daily Energy Intake from Fat with Insulin Resistance in Patients with Polycystic Ovary Syndrome

Objective: The aim of the present study was to investigate the possible correlation between the percentage of daily energy intake from fat (PEF) with insulin resistance (IR) in women with polycystic ovary syndrome (PCOS). Methods: In this cross-sectional study, a total of 186 females with PCOS were screened. Daily dietary intake data were collected by a trained nutritionist using the 24-h dietary recall method over three consecutive days. A total of 111 subjects who had complete data were divided into two groups based on the percentage of daily energy intake from fat (PEF): the normal PEF (NPEF) group (PEF < 30%) and the high PEF (HPEF) group (PEF ≥ 30%). Pearson’s correlation analysis and stepwise multivariate linear regression analysis were used to analyze the correlation of PEF with homeostasis model assessment of insulin resistance (HOMA-IR). Results: The total prevalence rate of overweight/obesity was 80.2%. There were significant differences in waist circumference (WC), body mass index (BMI), fasting insulin, and HOMA-IR (P < 0.001) among the normal weight, the overweight, and the obese groups, but no significant differences were observed in total energy and dietary macronutrients intake in the three groups. The daily intake of fat and protein, fasting insulin, and HOMA-IR in the NPEF group were significantly higher than those in the HPEF group. Pearson’s correlation analysis showed PEF in PCOS women was negatively correlated with BMI (r= −0.189, p=0.047) and HOMA-IR (log-transformed) (r= −0.217, p=0.022). Further, stepwise multivariate linear regression analysis showed PEF was negatively correlated with HOMA-IR (p<0.05). Conclusion: The percentage of daily energy intake from fat is negatively correlated with IR in women with PCOS.
Patient Portal Service: An Exploration of Patients’ Experience and Perception

— The New Zealand government is currently implementing electronic health records and encouraging general practices to enroll their patients into a patient portal service. Although literature shows the benefits of such a system for healthcare providers and patients, there is a lack of empirical research around patient’s experiences and requirements. This study aims to bring to light these through a survey research of a major patient portal. The survey data reveals issues around lack of consultation around the design, inconsistency in service uptake and lack of training on the use of the service. Overall, it reveals that the current patient portal system is not designed to the patient’s expectations.
ERG Expression and the Efficacy of Docetaxel Combined with Androgen Deprivation Therapy in Metastatic Hormone-Sensitive Prostate Cancer

Background: Our study aimed to analyze the potential association between clinical parameters and ERG expression and the outcome of docetaxel chemotherapy among patients with metastatic hormone-sensitive prostate cancer (mHSPC). Patients and methods : Fifty-five patients with mHSPC were treated with docetaxel in addition to androgen deprivation therapy (ADT). Patient characteristics, clinical factors, and tumor expression of ERG by immunohistochemistry were analyzed with respect to therapeutic response and survival data. Results : Relapse free survival (RFS) and overal survival (OS) were 10.5 and 40.4 months, respectively, and both correlated with PSA response (RFS: 16.8 with a ≥50% decrease in PSA vs. 5.9 months in the case of  50% decrease, p  0.001; OS: 40.4 vs. 11.6 months, respectively, p  0.001). There was an association between OS and early progression (OS: 40.4 months with progression after 12 months vs. 17.9 months with progression within 12 months, p=0.009). ERG expression was detected in 21 (42%) samples. ERG positivity was associated with favorable RFS (ERG pos. vs. neg.: 26.0 vs. 11.4 months, p=0.003). Conclusion: ERG expression may have a potential predictive value with respect to the effectiveness of docetaxel chemotherapy combined with ADT.