Miracle-dz/UniFAR-FTUs huggingface dataset:
Emergence of multiple resistance profiles involving azoles, echinocandins and amphotericin B in Candida glabrata isolates from a neutropenia patient with prolonged fungaemia.

ing (NG-MAST) genotyping performed. All six isolates displayed azithromycin MICs . 256 mg/L and contained the A2059G mutation in all four 23S RNA alleles. A single base pair deletion (A) in the mtrR promoter was present in isolates 1, 2, 3 and 6, but absent in isolates 4 and 5. The isolates comprised five different NG-MAST types (Table 1), suggesting independent generation of high-level azithromycin resistance. Limited epidemiological information was available, but isolates 1, 3, 4 and 6 were most likely acquired outside Australia (China and Hong Kong) or from contact with persons who had travelled to one of these countries. Isolate 2 was locally acquired. No details for isolate 5 were available, but it is of note that this isolate was the same NG-MAST type as isolate 4 (ST649). In summary, Australia is now included in the list of countries reporting gonococci with high-level resistance to azithromycin. While our national surveillance programme has detected just 6 isolates displaying high-level azithromycin resistance since 2011, further dissemination of such strains would threaten the long-term efficacy of the current recommended treatments for gonorrhoea.
Youths’ Views on Corruption Control in China

It has been asserted that criminal law and common morality are not sufficient terms to describe specific behaviors as corruption because those in power have the capacity to include or exclude certain behavior as a category in the law. Thus, corruption should not be just treated as an objective behavioral category but as a form of social censure. This article reports on a quantitative and qualitative study that collected the views of Chinese youth on the control of corruption in China. It was found that they agreed with the moral-negative judgements behind the censure of corruption, and that bureaucratic forces can be mobilised to punish the corrupt and degrade their status. Mediation analysis discovered that political functions mediate the association between the moral-negative nature and bureaucratic form of the censure of corruption and status degradation of the censured.
Factors Associated with Rape-Supportive Attitudes: Sociodemographic Variables, Aggressive Personality, and Sexist Attitudes

The objectives of this study were to determine the influence of various sociodemographic variables and estimate the impact of additional psychological factors (aggressive personality traits and the sexual double standard) on rape-supportive attitudes. A sample of 700 men and 800 women from El Salvador aged between 18 and 40 years completed the Social Desirability Scale, the Double Standard Scale, the Aggression Questionnaire, the State-Trait Anger Expression Inventory-2 and the Rape-Supportive Attitude Scale. Results show gender-based and age-based differences in rape-supportive attitudes, as well as an interaction between gender and age. They also highlight the importance of the sexual double standard and aggressive personality traits in explaining such attitudes. Los objetivos de este estudio fueron determinar la influencia de ciertas variables sociodemográficas y estimar el impacto de una serie de factores psicológicos adicionales (rasgos de personalidad agresiva y doble moral sexual) sobre las actitudes favorables hacia la violación. Una muestra comprendida por 700 hombres y 800 mujeres de El Salvador, con edades comprendidas entre los 18 y los 40 años, completaron la Escala de Deseabilidad Social, Escala de Doble Moral, Cuestionario de Agresión, Inventario de Expresión de la Ira Estado-Rasgo 2 y la Escala de Actitudes Favorables hacia la Violación. Los resultados mostraron diferencias en las actitudes favorables hacia la violación en función de la edad y el sexo, así como una interacción entre el sexo y la edad. También muestran la importancia de la doble moral sexual y los rasgos de personalidad agresiva en la explicación de dichas actitudes.
Some Diagnostic Aspect on Abnormal Nitric Oxide Metabolism and Some Pharmacological Aspects of the most used Drugs in Rheumatoid Arthritis

Introduction: To evaluate the diagnostic test for Assymetric Dimethyl Arginine (ADMA), rheumatoid factor (RF), C-reactive protein (CRP), Disease Activity Score with 28 joint ( DAS 28 index ), and to define the effect of untreated rheumatoid arthritis on endothelial function. In order to determine whether ADMA changes depending on the disease evolution, ADMA was used as an indicator for endothelial dysfunction in subclinical atherosclerosis Methods: Using a ELISA technology of DLD-Diagnostika-GMBH for detection of ADMA, the samples of serum and urine have been examined in 70 participants (35 RA who were not treated, 35 healthy controls). RF was defined with the test for agglutination (Latex RF test) in the same participants. Results: Out of 35 examined patients with RA, RF appeared in 18 patients (sensitivity of the test 48.57 %), while ADMA is positive in 20 patients (sensitivity of the test 57.14 %) in the same group. In 23 of the 35 examined patients with RA, we found presence of anti-citrulinated peptide antibodies (anti-CCP2) from the second generation (anti-CCP 2 antibodies ) (sensitivity of the test 65.71%). There is association between ADMA and anti-citrulated peptide antibodies (anti-CCP2) from the second generation in early RA (p<0.05). Conclusion: ADMA higher sensitivity than RF in the detection of asymptomatic subclinical lesions in untreated RA. ADMA has equal sensitivity and specificity from RF in untreated RA.
Annular erythema associated with Sjögren's syndrome preceding overlap syndrome of rheumatoid arthritis and polymyositis with anti-PL-12 autoantibodies.

A 44-year-old woman exhibited swelling with erythema on the bilateral upper eyelids. She was treated with prednisolone 20 mg/day at a different hospital. However, after the prednisolone was discontinued, the lesions relapsed. Four months after onset, the patient came to our clinic. A lip biopsy to investigate possible Sjogren’s syndrome (SS) confirmed lym phocytic infiltration of the minor salivary glands. Circulating autoantibodies to SS-A (anti-SS-A) were positive, but anti-SS-B antibodies were negative. She had no muscle weakness at any site of the body. Serum levels of creatinine kinase were not elevated. She was diagnosed with SS according to the Japanese Ministry of Health revised criteria for the diagnosis of SS (4). The lesions resolved with oral prednisolone 30 mg/day. When the prednisolone dose was reduced to 22.5 mg/day, several lesions of annular erythema (AE) appeared on the lower back (Fig. 1A). A biopsy of the AE lesion showed sleeve-like perivascular and periappendigeal lymphocytic infiltration, which was consistent with AE with SS (AESS) (Fig. 1B, C). The lesions resolved with oral prednisolone 30 mg/day and azathioprine 50 mg/day. Sixteen months after the onset of SS, arthralgia on the bilateral hip, knee, and ankle joints occurred. Oral prednisolone had been tapered to 10 mg/day, and oral azathioprine 50 mg/ day had been maintained. Physical examinations found swelling of the bilateral knee and ankle joints. Circulating anti-CCP antibodies were 453 U/ml (normal value < 15 U/ml). Serum levels of c-reactive protein and matrix metalloproteinase-3 Annular Erythema Associated with Sjogren’s Syndrome Preceding Overlap Syndrome of Rheumatoid Arthritis and Polymyositis with Anti-PL-12 Autoantibodies
The Anti-Communist Resistance in the Făgăraș Mountains (Romania) as a Challenge for Social Memory and an Exercise of Critical Thinking

The Anti-Communist Resistance in the Făgăraș Mountains (Romania) as a Challenge for Social Memory and an Exercise of Critical Thinking. Social memory is dynamic, adaptable to the ensemble of group perceptions on the present. In the first decade after WWII there were numerous active anti-communist armed resistance groups in the Romanian mountains. The most powerful resistance groups operated on the southern and northern sides of the Făgăraș Mountains. According to the results of exploratory research conducted in 2020 the representations of the anti-communist resistance in the mountains in Romanian young people’s memories are feeble. Retrieving representations of the resistance is useful as critical exercise in understanding history, as source of identity comfort and as part of the lesson on totalitarianism. Sociológia 2021, Vol. 53 (No. 3: 266-286) https://doi.org/10.31577/sociologia.2021. 53.3. 10
The challenges and opportunities in using real-world data to drive advances in healthcare in East Asia: expert panel recommendations

Abstract Objective To provide recommendations for overcoming the challenges associated with the generation and use of real-world evidence (RWE) in regulatory approvals, health technology assessments (HTAs), and reimbursement decision-making in East Asia. Methods A panel of experts convened at the International Society for Pharmacoeconomics and Outcomes Research Asia Pacific 2020 congress to discuss the challenges limiting the use of RWE in healthcare decision-making and to provide insights into the perspectives of regulators, HTA agencies, the pharmaceutical industry, and physicians in China, Japan, and Taiwan. A nonsystematic literature review was conducted to expand on the themes addressed. Results The use of RWE in regulatory approvals, HTAs, and reimbursement decision-making remains limited by legal/regulatory, technical, and attitudinal challenges in East Asia. Conclusions We recommend approaches and initiatives that aim to drive improvements in the utilization of RWE in healthcare decision-making in East Asia and other regions. We encourage large-scale collaborations that leverage the full range of skills offered by different stakeholders. Government agencies, hospitals, research organizations, patient groups, and the pharmaceutical industry must collaborate to ensure appropriate access to robust and reliable real-world data and seek alignment on how to address prioritized evidence needs. Increasingly, we believe that this work will be conducted by multidisciplinary teams with expertise in healthcare research and delivery, data science, and information technology. We hope this work will encourage further discussion among all stakeholders seeking to shape the RWE landscape in East Asia and other regions and drive next-generation healthcare.
Neural networks in finance : gaining predictive edge in the market

Preface 1. Introduction 2. What Are Neural Networks 3. Estimation of a Network with Evolutionary Computation 4. Evaluation of Network Estimation 5. Estimation and Forecasting with Artificial Data 6. Times Series: Examples from Industry and Finance 7. Inflation and Deflation: Hong Kong and Japan 8. Classification: Credit Card Default and Bank Failures 9. Dimensionality Reduction and Implied Volatility Forecasting
The Efficacy and Safety of 200 Days Valganciclovir Cytomegalovirus Prophylaxis in High‐Risk Kidney Transplant Recipients

Late‐onset cytomegalovirus (CMV) disease is a significant problem with a standard 3‐month prophylaxis regimen. This multicentre, double‐blind, randomized controlled trial compared the efficacy and safety of 200 days’ versus 100 days’ valganciclovir prophylaxis (900 mg once daily) in 326 high‐risk (D+/R–) kidney allograft recipients. Significantly fewer patients in the 200‐day group versus the 100‐day group developed confirmed CMV disease up to month 12 posttransplant (16.1% vs. 36.8%; p < 0.0001). Confirmed CMV viremia was also significantly lower in the 200‐day group (37.4% vs. 50.9%; p = 0.015 at month 12). There was no significant difference in the rate of biopsy‐proven acute rejection between the groups (11% vs. 17%, respectively, p = 0.114). Adverse events occurred at similar rates between the groups and the majority were rated mild‐to‐moderate in intensity and not related to study medication. In conclusion, this study demonstrates that extending valganciclovir prophylaxis (900 mg once daily) to 200 days significantly reduces the incidence of CMV disease and viremia through to 12 months compared with 100 days’ prophylaxis, without significant additional safety concerns associated with longer treatment. The number needed to treat to avoid one additional patient with CMV disease up to 12 months posttransplant is approximately 5.
A Ranking Analysis of the Management Schools in Greater China (2000–2010): Evidence From the SSCI Database

The authors rank the management schools in Greater China (including Mainland China, Hong Kong, Taiwan, and Macau) based on their academic publications in the Social Sciences Citation Index management and business journals from 2000 to 2010. Following K. Ritzberger's (2008) and X. Yu and Z. Gao's (2010) ranking method, the authors develop six indices to rank institutions from several aspects, including both the quantity and quality of publications. By doing so, they provide a clear viewpoint about which institutions achieve high levels of academic performance in management and business research. They also find that (a) there is still a large gap in research rankings between business schools in Mainland China and in Hong Kong; (b) some institutions perform well in quantity rankings but poorly in quality rankings; (c) the development of the general management and operation disciplines are much more mature than that of the finance and accounting disciplines in Greater China; and (d) most outstanding institutions cooperate with developed countries at a moderate level. The authors state their contributions and future directions as well.
Progression-Free Survival (PFS) by Blinded Independent Central Review (BICR) and Updated Overall Survival (OS) of Sunitinib versus Placebo for Patients with Progressive, Unresectable, Well Differentiated Pancreatic Neuroendocrine Tumor (NET)

EVMS Strelitz Diabetes Research Center and Neuroendocrine Unit, Norfolk, VA; University Hospital Gasthuisberg, Leuven, Belgium; University Hospital Timone, Paoli-Calmettes Institute and RENATEN Network, Marseille, France; Paoli-Calmettes Institute, Marseille, France; Seoul National University Hospital, Seoul, Republic of Korea; Cliniques Universitaires Saint-Luc, Brussels, Belgium; Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France; The Christie NHS Foundation Trust, Manchester, United Kingdom; McGill University Hospital Centre, Montreal, QC, Canada; Medical oncology, University Hospital, Bordeaux, France; Chang Gung Memorial Hospital and Chang Gung University, Taipei, Republic of China; Zentralklinik Bad Berka GmbH, Bad Berka, Germany; Hospital Universitario 12 de Octubre, Madrid, Spain; British Columbia Cancer Agency, Vancouver, BC, Canada; Washington University School of Medicine, St. Louis, MO; University of Western Australia, Perth, Australia; Pfizer Oncology, La Jolla, CA; Beaujon University Hospital, Clichy, France
Long-Term Outcomes of Pediatric Enterovirus Infection in Taiwan: A Population-Based Cohort Study

Introduction: The major burden of diseases in childhood has shifted from infectious diseases to chronic health conditions in recent decades. Although the rates of infectious diseases have decreased, the incidence of chronic diseases stemming from infectious agents continues to grow. Enterovirus is a major infectious disease of childhood and has been linked to numerous chronic diseases. We analyzed population-based data from Taiwan's National Health Insurance Research Database (NHIRD) to investigate the correlations between enterovirus infection and major chronic health conditions in children. Method: Children diagnosed with enterovirus (EV) infection during 1999–2003 were identified from the Longitudinal Health Insurance Database 2000 (LHID 2000), a subdataset of Taiwan's National Health Insurance Research Database (NHIRD). A total of 14,168 patients were selected after excluding patients with existing chronic diseases and missing data. Another 14,168 children matched by age and sex were selected as the control group. Five primary outcomes, including attention deficit and hyperactivity disorder (ADHD), epilepsy, asthma, allergic rhinitis, and atopic dermatitis, were recorded. Results: The risks of ADHD, asthma, allergic rhinitis, and epilepsy were significantly increased in the EV group compared with the control group. The risk of atopic dermatitis was significantly increased in the crude model. However, there were no significant differences in the adjusted model. The risks of ADHD, asthma, allergic rhinitis, and epilepsy were also significantly increased in patients with severe EV infection compared with patients with non-severe EV infection. Conclusion: Chronic diseases, such as ADHD, epilepsy, asthma, allergic rhinitis, and atopic dermatitis were shown to be associated with enterovirus infection during childhood. EV infection during early childhood might have long-term public health implications and thus prevention strategies should be implemented.
Dealer’s perception towards aqua feeds-A case study of avanti feeds limited, Kovvur, West Godavari Dt. of Andhra Pradesh

The first feed company was set up at Nellore district in Andhra Pradesh named as “Water Base” in the year 1992. The Indian aqua industry has collaborated with East Asian countries like Taiwan, Thailand etc. All the machinery and 83% of raw materials are imported from East Asian Countries. The R&D aspects are also imported from other countries but in India, the research and development departments are still underdeveloped. A sample of 200 dealers was taken for the purpose of this study with a structured questionnaire was drafted and distributed to dealers for collecting the primary data. Applying the theoretical models and the related statistical tools, the data collected by the researcher in the form of primary and secondary data, the hypothesis were tested and arrived at conclusions on the problem.
Title page Generation mechanism and dual dynamic simulations of surface patterns in single-point diamond turning of single-crystal copper

Sandy To, born in 1967, is currently a professor at The Hong Kong Polytechnic University and an associate director of State Key Laboratory of Ultra-precision Machining Technology. She received her PhD degree from The Hong Kong Polytechnic University, Hong Kong, China, in 2000. Her research interests include ultra-precision machining technology, material science and technology. E-mail: sandy.to@polyu.edu. hk
Perceived economic effects of the war in Ukraine: survey-based evidence from Italian firms

ABSTRACT Using data from an Italian business survey and a quasi-experimental analysis, we document the effects of the Russian invasion of Ukraine on firms’ expectations. The conflict led firms to revise upward their inflation expectations and their own expected prices changes and made them more pessimistic about the general macroeconomic outlook and their business conditions. These effects did not materialize immediately after the Russian invasion but built up in the second and third weeks thereafter.
Extreme Candidates as the Beneficent Spoiler? Range Effect in the Plurality Voting System

How does the entrance of radical candidates influence election results? Conventional wisdom suggests that extreme candidates merely split the votes. Based on the range effect theory in cognitive psychology, we hypothesize that the entrance of an extreme candidate reframes the endpoints of the ideological spectrum among available candidates, which makes the moderate one on the same side to be perceived by the voters as even more moderate. Through two survey experiments in the United States and Taiwan, we provide empirical support for range effect in the vote choice in the plurality system. The results imply that a mainstream party can, even without changing its own manifesto, benefit from the entrance of its radical counterpart; it explains why the mainstream party may choose cooperation strategically. Our findings also challenge the assumption in regression models that the perceived ideological positions of candidates are independent of each other.
Physiochemical and protein profiling of Bacaurea ramiflora (Burmese grape) - an underutilized fruit crop in Arunachal Pradesh

A survey was conducted in the Napit, Pekung and Runne village of East Siang district of Arunachal Pradesh, India during the period 2015-2016 for the documentation on the variability of Bacaurea ramiflora (Burmese grape) in this region. These plants are found wild or in the homestead garden. From the investigation two types of morphotype could be identified in this region (mild acidic and sweet type). Study on its different physical and quality parameters revealed that the sweetness ranges from 12.5 to 16.5° Brix and the fruit parameters like fruit weight, pulp weight, fruit juice, TSS, total sugar and acidity are found to be significant among the genotypes. However, the biochemical marker (SDS PAGE) revealed monomorphic banding pattern and no variable is found in among the genotypes which can be confirmed using molecular marker in the near future.
Nectar secretion and pollen production in protandrous flowers of Campanula patula L. (Campanulaceae)

Nectar secretion was noted both in the male and female floral phases of the protandrous flowers of Campanula patula (Campanulaceae). Female-biased sugar accumulation was evidenced and plasticity in the duration of sexual phases observed. Flowers in the male phase produced twofold less nectar with lower sugar concentrations compared to female-phase flowers. The sugar mass content averaged 0.6 mg ±0.45 SD per flower in the male phase and 1.4 ±0.5 SD per flower in the female phase. The pollen mass averaged 0.16 mg ±0.10 SD per flower. An understanding of the evolution of functional relationships between floral sexes requires consideration of the compensation of the reproductive costs, including the plastic response to interdependent factors, i.e., photosynthesis and growth, the effect of pollinators, pollen robbers, and external environmental forces.
Habitat Preference of an Endangered Hill Stream Catfish Olyra longicaudata (McClelland) From Arunachal Pradesh, India

Habitat predilection of Olyra longicaudata, was studied systematically in a mountain stream of Dengka village of papumpare district Arunachal Pradesh, India. The enumeration of habitat parameters in-situ revealed that this catfish has the specialized and distinguishable habitat fondness in lotic system. This fish is basically bottom dweller and prefers the places with rocky stream beds, devoid of clay and detrital deposits, surrounding areas enriched with larval and aquatic insects, crustaceans, annelids, molluscs etc. The fish prefers shallower and clear running water but cool, soft, slightly alkaline with high level of dissolved oxygen and under a good cover of riparian vegetation. The population properties of the species showed a dismal picture with adult count going remarkably down.