Miracle-dz/UniFAR-FTUs huggingface dataset:
Case report: Autoimmune encephalitis with multiple auto-antibodies with reversible splenial lesion syndrome and bilateral ovarian teratoma

Background Reversible splenial lesion syndrome (RESLES) is a spectrum of disease radiologically characterized by reversible lesions caused by multiple factors, primarily involving the splenium of the corpus callosum (SCC). The most common causes of RESLES include infection, antiepileptic drug use and withdrawal, and severe metabolic disorders. Nevertheless, cases of autoimmune encephalitis (AE) are uncommon. Case presentation A 26-year-old female computer programming engineer with no previous medical or psychiatric history reported to the psychiatric hospital due to a 3-day episode of irritability, babbling, limb stiffness, sleepwalking, hallucinations, and paroxysmal mania. Brain MRI revealed abnormal signals of the SCC. Lumbar puncture was performed and further testing for auto-antibodies was conducted in both the CSF and serum. CSF of the patient was positive for anti-NMDAR (titer of 1:3.2) antibodies, and serum was also positive for anti-NMDAR (titer of 1:32) as well as mGluR5 (titer of 1:10) antibodies. Enhanced CT of the pelvis showed an enlarged pelvic mass; bilateral ovarian teratomas (mature teratoma and immature teratoma) were evaluated, which were pathologically confirmed after transabdominal left adnexal resection, right ovarian biopsy, and ovarian cystectomy. The patient considerably improved after intravenous administration of steroids, immunoglobulin, oral prednisone, surgical treatment, and chemotherapy. A follow-up MRI revealed completely resolved lesions. During a 3-month follow-up, the patient experienced complete resolution of symptoms without any sign of recurrence and tumors. The titer of the anti-NMDAR antibody decreased to 1:10 in serum. Conclusion Herein, we report a rare case of AE with overlapping auto-antibodies, along with RESLES and bilateral ovarian teratomas. The current case provides the possibility of the concurrence of mGluR5 antibodies in anti-NMDAR encephalitis. However, the underlying mechanism remains elusive. Furthermore, we provide additional evidence that overlapping antibodies-related pathology may be one of the many causes of RESLES. Nonetheless, caution should be observed in interpreting the observation, considering that this is a single-case study.
Quantitative analysis of knowledge, attitude and practice of workers in chicken slaughter slabs toward food safety and hygiene in Ouagadougou, Burkina Faso

Introduction In low- and middle-income countries, chicken serves as a cheap source of protein and an income source for many households. It is particularly important in the capital, Ouagadougou, Burkina Faso, where chicken is regularly consumed. However, hygiene standards are very low, posing a significant public health risk. Methods To better understand the food safety situation, we conducted a cross-sectional survey of the hygienic practices of 155 randomly selected chicken slaughter outlets and carcass shops with a semi-structured questionnaire. Results and discussion Of the outlets visited, 59% are not licensed, and 63% are not regularly inspected, operating in the dominant, largely unregulated informal sector. More than 80% of the chickens are sourced from village production systems, but around 6% of the birds die during transport. The monetary loss due to chicken death during transportation is around four million USD annually. Market hygiene is poor; 86% of the holding pens have no hard floor and are not washed regularly. Almost all (92%) chickens are slaughtered on bare earth floors; bleeding, plucking, and evisceration are done on a wooden table that is rarely washed. On average, the same scalding water is used for 33 birds, seven scalded at a time. Most respondents (49%) thought that plucking and evisceration were the major cause of contamination of carcasses with foodborne pathogens. Most operators only washed their hands and knives with tap water at the beginning of the slaughtering process. Some shops use refrigerators and freezers to store carcasses before selling. However, they store carcasses with other foods like fish, beef and vegetables, facilitating further cross-contamination. There were rats (26%), cats (39%) and dogs (30%) present at outlets, roaming for food, especially roadside outlets. Training schemes on hygienic food handling practices were favoured by outlets as an approach to improve matters; however, improvements in food safety will be limited without significant upgrades in infrastructure and facilities. Slaughter slabs need a standard house with stable energy, adequate airflow, clean water, toilets, detergents and freezers. Also, they need equipment like knives, tables and dishes made of high-quality, easy-to-clean materials.
Research trends and hotspots of neurodegenerative diseases employing network pharmacology: A bibliometric analysis

Background: Employing network pharmacology in neurodegenerative diseases (NDs) has been extensively studied recently. However, no comprehensive study has conducted on this subject employing bibliometrics so far. The purpose of this study was to find out the developmental trends and hotspots, and to predict potential research directions in this filed. Methods: Relevant research were collected from the Web of Science Core Collection Bibliometrics and visual analysis were executed using CiteSpace, VOSviewer, Histcite and R-bibliometrix. Results: A total of 420 English articles on network pharmacology in NDs published in 2008–2022 were obtained from the WOSCC database. From 2008 to 2022, annual publications showed a steady growing trend, especially in 2014–2022. China, Beijing Univ Chinese Med, Frontiers in Pharmacology, and Geerts H are the most prolific country, institution, journal, and author, respectively. China, Nucleic Acids Research, and Hopkins AL are the most highly cited country, journal, and author, respectively. Moreover, network pharmacology and Alzheimer’s disease are the focal areas of current researches according to analysis of co-cited references and keywords. Finally, in the detection of burst keywords, systems pharmacology and database are new approaches to disease and drug research, while traditional Chinese medicine (TCM) and Alzheimer’s disease are hot research directions. The above keywords are speculated to be the research frontiers. Conclusion: Network pharmacology and Alzheimers’ disease are the main topics of researches on network pharmacology in NDs. Network pharmacology and the TCM treatment of Alzheimer’s disease have been the recent research hotspots. To sum up, the potential for exploring TCM treatment of AD with network pharmacology is huge.
Celsr1 and Celsr2 exhibit distinct adhesive interactions and contributions to planar cell polarity

Cadherin EGF LAG seven-pass G-type receptor (Celsr) proteins 1-3 comprise a subgroup of adhesion GPCRs whose functions range from planar cell polarity (PCP) signaling to axon pathfinding and ciliogenesis. Like its Drosophila ortholog, Flamingo, mammalian Celsr1 is a core component of the PCP pathway, which, among other roles, is responsible for the coordinated alignment of hair follicles across the skin surface. Although the role of Celsr1 in epidermal planar polarity is well established, the contribution of the other major epidermally expressed Celsr protein, Celsr2, has not been investigated. Here, using two new CRISPR/Cas9-targeted Celsr1 and Celsr2 knockout mouse lines, we define the relative contributions of Celsr1 and Celsr2 to PCP establishment in the skin. We find that Celsr1 is the major Celsr family member involved in epidermal PCP. Removal of Celsr1 function alone abolishes PCP protein asymmetry and hair follicle polarization, whereas epidermal PCP is unaffected by loss of Celsr2. Further, elimination of both Celsr proteins only minimally enhances the Celsr1 −/− phenotype. Using FRAP and junctional enrichment assays to measure differences in Celsr1 and Celsr2 adhesive interactions, we find that compared to Celsr1, which stably enriches at junctional interfaces, Celsr2 is much less efficiently recruited to and immobilized at junctions. As the two proteins seem equivalent in their ability to interact with core PCP proteins Vangl2 and Fz6, we suggest that perhaps differences in homophilic adhesion contribute to the differential involvement of Celsr1 and Celsr2 in epidermal PCP.
Linking top and subsoil types, alteration and degassing processes at Rotokawa geothermal field, New Zealand

Surface geothermal expressions such as mud pools, fumaroles, mineral deposits, collapse pits, and hydrothermal eruption craters vary in scale and type over space and time. The evolution in space and time of these surficial thermal features strongly relates to alteration processes caused by hydrothermal fluids. The changes in the physical and mechanical properties of top and subsoils that can control fluid flow, degassing patterns, and occurrence of geothermal hazards remain understudied. The thermal area located south of the Rotokawa geothermal field (New Zealand) includes a variety of major natural surface thermal features and widespread sulphur deposits precipitated by acid–sulphate fluids in steam-heated zones. Decades of sulphur mining induced the formation of new thermal features. Such a setting represents an exemplary case study for investigating old and recently formed thermal features, soil characteristics, types and patterns of superposed hydrothermal alteration, and degassing processes. We combined field and laboratory methods to define groups of thermal features, soil types, and associated alteration. Their spatial distribution indicates that fluid circulation, alteration intensity, and degassing are strongly influenced by the local and regional geological and structural settings, as well as by mining activity. We found that at the water table level and within excavated areas, acidic fluids led to the deposition of mud deposits, sinters, and stromatolites around warm springs and mud pools. In the vadose, steam-heated portions, fluids generally leach and degrade the Taupo Pumice, resulting in broad unstable grounds and collapse structures, while extensive sulphur-encrusted grounds and sulphur-rich soils formed in excavated sites. In this framework, the degassing and fluid circulation within the top and subsoils are strongly affected by the dominant soil layer type, and in turn by its granulometry, texture, and alteration state. Our study of top and subsoils yields precious insights into surface expression variability, fluid–rock interaction processes, and sulphur deposition patterns within steam-heated zones. Processes at such a scale may strongly influence the migration of thermal manifestations, gas outputs, and ground subsidence within geothermal environments. From a broader perspective, our results will help assess the evolution of geothermal activity and related hazards in similar areas worldwide.
Automatic identification of conodont species using fine-grained convolutional neural networks

Conodonts are jawless vertebrates deposited in marine strata from the Cambrian to the Triassic that play an important role in geoscience research. The accurate identification of conodonts requires experienced professional researchers. The process is time-consuming and laborious and can be subjective and affected by the professional level and opinions of the appraisers. The problem is exacerbated by the limited number of experts who are qualified to identify conodonts. Therefore, a rapid and simple artificial intelligence method is needed to assist with the identification of conodont species. Although the use of deep convolutional neural networks (CNN) for fossil identification has been widely studied, the data used are usually from different families, genera or even higher-level taxonomic units. However, in practical geoscience research, geologists are often more interested in classifying species belonging to the same genus. In this study, we use five fine-grained CNN models on a dataset consisting of nine species of the conodont genus Hindeodus. Based on the cross-validation results, we show that using the Bilinear-ResNet18 model and transfer learning generates the optimal classifier. Area Under Curve (AUC) value of 0.9 on the test dataset was obtained by the optimal classifier, indicating that the performance of our classifier is satisfactory. In addition, although our study is based on a very limited taxa of conodonts, our research principles and processes can be used as a reference for the automatic identification of other fossils.
Marine sediment nitrogen isotopes and their implications for the nitrogen cycle in the sulfate-methane transition zone

Introduction Recent work has proposed that the nitrogen isotopes in marine sediments can be impacted by anaerobic oxidation of methane (AOM), since nitrogen uptake by anaerobic methanotrophic archaea (ANME) modifies the nitrogen isotope compositions of bulk sediment. Thus, unraveling the AOM-driven nitrogen cycle in the sulfate-methane transition zone (SMTZ) becomes significant. Additional study of the nitrogen cycle between sediment and interstitial water in SMTZ is needed. Methods To better understand the nitrogen cycle in the SMTZ, we analyzed NH4+ concentrations of interstitial water and nitrogen isotopes of sediment in the core GC10 from the southwestern Taiwan Basin in the South China Sea. Results The defined SMTZ is located at 560–830 cmbsf, based on methane and sulfate concentrations, as well as TS/TOC ratios, δ13CTIC and δ34S values. In the SMTZ, the NH4+ concentration decreases, the δ15NTN shows a negative excursion, δ15Ndecarb displays a positive excursion. Discussions NH4+ concentration decrease is interpreted by sulfate-reducing ammonium oxidation (SRAO). The δ15NTN shows negative excursion, which is most likely interpreted to N2 (δ15N=0‰) released from SRAO that was fixed into marine sediment via ANME nitrogen fixation. The δ15Ndecarb shows a negative correlation with NH4+ concentrations, indicating that it was controlled by organic matter decomposition. In the SMTZ, the methane competes with organic matter for becoming the substrate of sulfate reduction bacteria, which possibly decreases the organic matter degradation rate and causes δ15Ndecarb relative positive excursion. Although δ15Ndecarb is controlled by organic matter degradation, δ15NTN still reveals a negative excursion in the SMTZ. This likely indicates that nitrogen uptake by ANME/AOM microbial consortiums mainly modifies the nitrogen isotope of soluble nitrogen in the SMTZ. Conclusions This study indicates unique geochemistry processes in SMTZ will modify nitrogen characteristics in sediment/interstitial water, and the latter can serve as a proxy for AOM.
SPIRALS, BRIDGES, AND TAILS: A GALAXY EVOLUTION EXPLORER ULTRAVIOLET ATLAS OF INTERACTING GALAXIES

We have used the Galaxy Evolution Explorer (GALEX) ultraviolet telescope to study stellar populations and star formation morphology in a well-defined sample of 42 nearby optically selected pre-merger interacting galaxy pairs. Galaxy interactions were likely far more common in the early universe than in the present; thus our study provides a nearby well-resolved comparison sample for high-redshift studies. We have combined the GALEX near-ultraviolet (NUV) and far-ultraviolet images with broadband optical maps from the Sloan Digitized Sky Survey to investigate the ages and extinctions of the tidal features and the disks. The distributions of the UV/optical colors of the tidal features and the main disks of the galaxies are similar; however, the tidal features are bluer on average in NUV − g when compared with their own parent disks; thus tails and bridges are often more prominent relative to the disks in UV images compared to optical maps. This effect is likely due to enhanced star formation in the tidal features compared to the disks rather than reduced extinction; however, lower metallicities may also play a role. We have identified a few new candidate tidal dwarf galaxies in this sample. Other interesting morphologies such as accretion tails and “beads on a string” are also seen in these images. We also identify a possible “Taffy” galaxy in our sample, which may have been produced by a head-on collision between two galaxies. In only a few cases are strong tidal features seen in H i maps but not in GALEX.
Cardiac regeneration: Options for repairing the injured heart

Cardiac regeneration is one of the grand challenges in repairing injured human hearts. Numerous studies of signaling pathways and metabolism on cardiac development and disease pave the way for endogenous cardiomyocyte regeneration. New drug delivery approaches, high-throughput screening, as well as novel therapeutic compounds combined with gene editing will facilitate the development of potential cell-free therapeutics. In parallel, progress has been made in the field of cell-based therapies. Transplantation of human pluripotent stem cell (hPSC)-derived cardiomyocytes (hPSC-CMs) can partially rescue the myocardial defects caused by cardiomyocyte loss in large animals. In this review, we summarize current cell-based and cell-free regenerative therapies, discuss the importance of cardiomyocyte maturation in cardiac regenerative medicine, and envision new ways of regeneration for the injured heart.
Editorial: Neuroprotection and disease modification in Parkinson’s disease: Volume II

Consejo Nacional de Investigaciones Cientificas y Tecnicas, Universidad Abierta Interamericana-Centro de Altos Estudios en Ciencias Humanas y de La Salud, UAI-CAECIHS CONICET, Buenos Aires, Argentina, CNRS, IBDM, UMR7288, Aix-Marseille University, Marseille, France, Instituto de Ciencias Biomedicas, Facultad de Ciencias de la Salud, Universidad Autonoma de Chile, Santiago de Chile, Chile, Observatorio de Salud Pública, Pontificia Universidad Católica Argentina (UCA), Buenos Aires, Argentina, Department of Physiology, Faculty of Medicine, University of Buenos Aires (UBA), Buenos Aires, Argentina, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
DenseNet weed recognition model combining local variance preprocessing and attention mechanism

Introduction The purpose of this paper is to effectively and accurately identify weed species in crop fields in complex environments. There are many kinds of weeds in the detection area, which are densely distributed. Methods The paper proposes the use of local variance pre-processing method for background segmentation and data enhancement, which effectively removes the complex background and redundant information from the data, and prevents the experiment from overfitting, which can improve the accuracy rate significantly. Then, based on the optimization improvement of DenseNet network, Efficient Channel Attention (ECA) mechanism is introduced after the convolutional layer to increase the weight of important features, strengthen the weed features and suppress the background features. Results Using the processed images to train the model, the accuracy rate reaches 97.98%, which is a great improvement, and the comprehensive performance is higher than that of DenseNet, VGGNet-16, VGGNet-19, ResNet-50, DANet, DNANet, and U-Net models. Discussion The experimental data show that the model and method we designed are well suited to solve the problem of accurate identification of crop and weed species in complex environments, laying a solid technical foundation for the development of intelligent weeding robots.
Electron microscopic imaging and NanoSIMS investigation on physiological responses of Aspergillus niger under Pb(II) and Cd(II) stress

In the bioremediation process, coexistence of lead (Pb) and cadmium causes complex toxicity, resulting in the difficulty of bioremediation. This study investigated the physiological responses and bioaccumulation mechanisms of the typical filamentous fungus Aspergillus niger under the coexistence of Pb and Cd. Four treatments were set up, i.e., control, sole Pb, sole Cd, and coexistence of Pb and Cd. The morphology of A. niger were observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), respectively. Then, nano-scale secondary ion mass spectrometry (NanoSIMS) was applied to accurately investigate the distribution of heavy metals in the fungal cells under the coexistence of Pb and Cd. Finally, the metallogenic process and mineral types were simulated by Geochemist’s Workbench (GWB). The electron microscopic and NanoSIMS imaging showed that Pb and Cd were accumulated in both the extracellular and intracellular regions of the A. niger cells. In particular, the accumulated Pb content was ten times higher than that of Cd. However, Cd showed stronger toxicity than Pb to A. niger. Compared with the control treatment, Cd stress resulted in a two-fold increase of cell diameter and more extracellular substances, whereas the cell diameter increased nearly four times in the coexistence treatment. Moreover, the bioaccumulation of Pb was more intense than that of Cd during competitive sorption. The GWB simulation confirmed that Pb2+ can form multiple minerals (e.g., PbC2O4, PbHPO4, and Pb3(PO4)2, etc.), which significantly weakened its toxicity on the cell surface. This study elucidated the morphological characteristics of A. niger and competitive bioaccumulation under the coexistence of Pb and Cd, which would facilitate the application of microorganisms to the bioremediation of coexisted metals.
Asymptomatic carotid stenosis is associated with both edge and network reconfigurations identified by single-subject cortical thickness networks

Background and purpose Patients with asymptomatic carotid stenosis, even without stroke, are at high risk for cognitive impairment, and the neuroanatomical basis remains unclear. Using a novel edge-centric structural connectivity (eSC) analysis from individualized single-subject cortical thickness networks, we aimed to examine eSC and network measures in severe (> 70%) asymptomatic carotid stenosis (SACS). Methods Twenty-four SACS patients and 24 demographically- and comorbidities-matched controls were included, and structural MRI and multidomain cognitive data were acquired. Individual eSC was estimated via the Manhattan distances of pairwise cortical thickness histograms. Results In the eSC analysis, SACS patients showed longer interhemispheric but shorter intrahemispheric Manhattan distances seeding from left lateral temporal regions; in network analysis the SACS patients had a decreased system segregation paralleling with white matter hyperintensity burden and recall memory. Further network-based statistic analysis identified several eSC and subgraph features centred around the Perisylvian regions that predicted silent lesion load and cognitive tests. Conclusion We conclude that SACS exhibits abnormal eSC and a less-optimized trade-off between physical cost and network segregation, providing a reference and perspective for identifying high-risk individuals.