Miracle-dz/UniFAR-FTUs huggingface dataset:
Epigenotoxicity: a danger to the future life

Abstract Environmental toxicants can regulate gene expression in the absence of DNA mutations via epigenetic mechanisms such as DNA methylation, histone modifications, and non-coding RNAs’ (ncRNAs). Here, all three epigenetic modifications for seven important categories of diseases and the impact of eleven main environmental factors on epigenetic modifications were discussed. Epigenetic-related mechanisms are among the factors that could explain the root cause of a wide range of common diseases. Its overall impression on the development of diseases can help us diagnose and treat diseases, and besides, predict transgenerational and intergenerational effects. This comprehensive article attempted to address the relationship between environmental factors and epigenetic modifications that cause diseases in different categories. The studies main gap is that the precise role of environmentally-induced epigenetic alterations in the etiology of the disorders is unknown; thus, still more well-designed researches need to be accomplished to fill this gap. The present review aimed to first summarize the adverse effect of certain chemicals on the epigenome that may involve in the onset of particular disease based on in vitro and in vivo models. Subsequently, the possible adverse epigenetic changes that can lead to many human diseases were discussed.
On the Cohomology of Doi–Hopf Modules

Let H be a Hopf algebra over a field k, and (H, A, C) be a Doi–Hopf datum. The categories of comodules over C and Doi–Hopf modules are then the Grothendieck categories with enough injectives. We study the derived functors of the associated Hom functors, and of the coinvariants functor, and discuss spectral sequences that connect them. We also discuss when the coinvariants functor preserves injectives.
Parasite and host kinases as targets for antimalarials

ABSTRACT Introduction The deployment of Artemisinin-based combination therapies and transmission control measures led to a decrease in the global malaria burden over the recent decades. Unfortunately, this trend is now reversing, in part due to resistance against available treatments, calling for the development of new drugs against untapped targets to prevent cross-resistance. Areas covered In view of their demonstrated druggability in noninfectious diseases, protein kinases represent attractive targets. Kinase-focussed antimalarial drug discovery is facilitated by the availability of kinase-targeting scaffolds and large libraries of inhibitors, as well as high-throughput phenotypic and biochemical assays. We present an overview of validated Plasmodium kinase targets and their inhibitors, and briefly discuss the potential of host cell kinases as targets for host-directed therapy. Expert opinion We propose priority research areas, including (i) diversification of Plasmodium kinase targets (at present most efforts focus on a very small number of targets); (ii) polypharmacology as an avenue to limit resistance (kinase inhibitors are highly suitable in this respect); and (iii) preemptive limitation of resistance through host-directed therapy (targeting host cell kinases that are required for parasite survival) and transmission-blocking through targeting sexual stage-specific kinases as a strategy to protect curative drugs from the spread of resistance.
Laser-frequency locking using light-pressure-induced spectroscopy in a calcium beam

We demonstrate a spectroscopy method that can be applied in an atomic beam, light-pressure-induced spectroscopy (LiPS). A simple pump and probe experiment yields a dispersivelike spectroscopy signal that can be utilized for laser frequency stabilization. The underlying principles are discussed and compared to Monte Carlo simulations. The shape of the dispersive signal is well described by the simulations. The zero crossing point of the signal is redshifted with respect to the atomic resonance by similar to 3 MHz (one-tenth of the natural linewidth) and depends slightly on the laser intensity. The shift of the zero crossing is determined by laser-induced fluorescence and compared with results of Doppler-free saturation spectroscopy. To check the potential of LiPS for frequency stabilization purposes, it was used to frequency-stabilize the laser for 400 min. Frequency fluctuations of only 0.12 MHz were measured.
Advances in trauma care to save lives from traumatic injury: A narrative review

Trauma resuscitation may be seen through sequential steps that occur in parallel and in series; these interventions are at both the patient and system level to optimize and individualize trauma care. ABSTRACT Recent advances on trauma management from the prehospital setting to in hospital care led to a better surviving severe trauma rate. Mortality from exsanguination remains the first preventable mortality. Damage-control resuscitation and surgery are evolving and thus some promising concepts are developing. Transfusion toolkit is brought on the prehospital scene while temporary bridge to hemostasis may be helpful. Panel transfusion products allow an individualized ratio assumed by fresh frozen or lyophilized plasma, fresh or cold-stored whole blood, fibrinogen, four-factor prothrombin complex concentrates. Growing interest is raising in whole blood transfusion, resuscitative endovascular balloon occlusion of the aorta use, hybrid emergency room, viscoelastic hemostatic assays to improve patient outcomes. Microcirculation, traumatic endotheliopathy, organ failures and secondary immunosuppression are point out since late deaths are increasing and may deserve specific treatment. As each trauma patient follows his own course over the following days after trauma, trauma management may be seen through successive, temporal, and individualized aims.
Digital physiotherapy assessment vs conventional face-to-face physiotherapy assessment of patients with musculoskeletal disorders: A systematic review

Background This systematic review aimed to assess the certainty of evidence for digital versus conventional, face-to-face physiotherapy assessment of musculoskeletal disorders, concerning validity, reliability, feasibility, patient satisfaction, physiotherapist satisfaction, adverse events, clinical management, and cost-effectiveness. Methods Eligibility criteria: Original studies comparing digital physiotherapy assessment with face-to-face physiotherapy assessment of musculoskeletal disorders. Systematic database searches were performed in May 2021, and updated in May 2022, in Medline, Cochrane Library, Cinahl, AMED, and PEDro. Risk of bias and applicability of the included studies were appraised using the Quality Assessment of Diagnostic Accuracy Studies-2 tool and the Quality Appraisal of Reliability Studies tool. Included studies were synthesised narratively. Certainty of evidence was evaluated for each assessment component using GRADE. Results Ten repeated-measures studies were included, involving 193 participants aged 23–62 years. Reported validity of digital physiotherapy assessment ranged from moderate/acceptable to almost perfect/excellent for clinical tests, range of motion, patient-reported outcome measures (PROMs), pain, neck posture, and management decisions. Reported validity for assessing spinal posture varied and was for clinical observations unacceptably low. Reported validity and reliability for digital diagnosis ranged from moderate to almost perfect for exact+similar agreement, but was considerably lower when constrained to exact agreement. Reported reliability was excellent for digital assessment of clinical tests, range of motion, pain, neck posture, and PROMs. Certainty of evidence varied from very low to high, with PROMs and pain assessment obtaining the highest certainty. Patients were satisfied with their digital assessment, but did not perceive it as good as face-to-face assessment. Discussion Evidence ranging from very low to high certainty suggests that validity and reliability of digital physiotherapy assessments are acceptable to excellent for several assessment components. Digital physiotherapy assessment may be a viable alternative to face-to-face assessment for patients who are likely to benefit from the accessibility and convenience of remote access. Trial registration The review was registered in the PROSPERO database, CRD42021277624.
A MARKOV RENEWAL APPROACH TO THE ASYMPTOTIC DECAY OF THE TAIL PROBABILITIES IN RISK AND QUEUING PROCESSES

It is well known that various characteristics in risk and queuing processes can be formulated as Markov renewal functions, which are determined by Markov renewal equations. However, those functions have not been utilized as they are expected. In this article, we show that they are useful for studying asymptotic decay in risk and queuing processes under a Markovian environment. In particular, a matrix version of the Cramér–Lundberg approximation is obtained for the risk process. The corresponding result for the MAP/G/1 queue is presented as well. Emphasis is placed on a straightforward derivation using the Markov renewal structure.
Andexanet alfa in acute aortic syndrome: first UK experience.

Andexanet alfa was employed to reverse the anticoagulant effect of direct oral anticoagulants in 3 patients who required emergent surgery for repair of type A aortic dissection. Its use was instrumental in securing haemostasis. However, we caution against the administration of Andexanet alfa prior to cardiopulmonary bypass as it can induce heparin resistance and complicate the perioperative monitoring of anticoagulation during CPB.
Detection of Luminous Intracluster Extreme-Ultraviolet Emission from Abell 1795

We have observed the rich cluster Abell 1795 for 90,000 s, using the deep survey telescope aboard the Extreme-Ultraviolet Explorer, with the Lex/B (69-190 eV) passband filter. Very luminous emission was detected, with a marked softening of the spectrum toward the limiting sensitivity radius of 10' (~0.67 Mpc, assuming here and thereafter a Hubble constant of 75 km s−1 Mpc−1), where the EUV intensity is 6 times higher than that expected from the low-energy tail of the thermal X-ray emission, and the resulting EUV luminosity (a model-independent quantity) exceeds that of the X-ray band. The consequence of a thermal model interpretation is the existence of a warm (sub-MK) intracluster gas that is dynamical (cooling times ≤10−4 of a Hubble time) and that contains a significant fraction, perhaps all, of the total missing mass of the cluster. Alternative interpretations of the data also invoke assumptions that have significant ramifications in our understanding of clusters.
MIMOSA: A resource consisting of improved methylome imputation models increases power to identify DNA methylation-phenotype associations

DNA methylation has been shown to be involved in the etiology of many complex diseases, yet the specific key underlying methylation sites remain largely unknown. One strategy to identify putative causal CpG sites and enhance disease etiology understanding is to conduct methylome-wide association studies (MWASs), in which predicted or measured DNA methylation that is associated with complex diseases can be identified. However, current MWAS models are trained with relatively small reference datasets, limiting the ability to adequately handle CpG sites with low genetic heritability. Here, we introduce a new resource, MWAS Imputing Methylome Obliging Summary-level mQTLs and Associated LD matrices (MIMOSA), a set of models that substantially improve the prediction accuracy of DNA methylation and subsequent MWAS power through the use of a large, summary-level mQTL dataset provided by the Genetics of DNA Methylation Consortium (GoDMC). With the analyses of GWAS summary statistics for 28 complex traits and diseases, we demonstrate that MIMOSA considerably increases the accuracy of DNA methylation prediction in blood, crafts fruitful prediction models for low heritability CpG sites, and determines markedly more CpG site-phenotype associations than preceding methods.
Chains that realize the Gromov invariant of hyperbolic manifolds

For any closed hyperbolic manifold of dimension $n \geq 3$, suppose a sequence of $n$-cycles representing the fundamental homology class have norms converging to the Gromov invariant. We show that this sequence must converge to the uniform measure on the space of maximal-volume ideal simplices. As a corollary, we show that for a hyperbolic $n$-manifold $L$ ($n \geq 3$) with totally-geodesic boundary, the Gromov norm of ($L,\partial L$) is strictly greater than the volume of $L$ divided by the maximal volume of an ideal $n$-simplex.
A harmonic balance technique for the analysis of periodic attractors and their bifurcations in CNNs

The occurrence of periodic attractors in CNNs is investigated through a harmonic balance technique. It is shown that for a N-cell CNN described by the template [a/sub -1/, a/sub 0/, a/sub 1/], this technique leads to a set of 3N nonlinear equations, that can be reduced to 2N+1 equations through suitable algebraic manipulations. The technique allows to determine all the limit cycles and most of the bifurcation phenomena occurring in the network. The results are in good agreement with those observed by the time-simulation of the network.
Evidence and concepts for non-local transport

Until a few years ago, most transient transport studies observed primarily diffusive plasma transport responses to fast, localized perturbations. Recently, several experiments have, in addition, observed `non-local' electron heat responses. Most remarkably, in `cold-pulse' experiments the abrupt edge cooling via radiative processes can induce both a diffusive cooling response moving in from the edge and, simultaneously, a rising electron temperature in the central core of tokamak plasmas - an opposite response even before the diffusive cooling from the edge reaches the centre! These and other non-local electron heat transport conundra from recent experiments are reviewed. The models and physical processes advanced to explain these puzzling phenomena are also discussed. The importance of resolving this transport enigma is emphasized.
Personal Narratives of Mental Illness: From Hostage to Survivor

Abstract This study has delved into personal narratives extracted from online blogs to build a systematic view of mental illness trajectory through the portrayal offered by bloggers. One hundred and thirty-three blogs were reviewed and narrative analysis was used to interpret a final sample of 12 blogs. The results offer two main narratives—the hostage and the survivor—which illustrate, within the context of social and self-stigma, the need for an identity reformulation in order to reach recovery. The two narratives also led to the design of a model for mental illness trajectory (MMIT). The breaking down of mental illness trajectory into phases could be advantageous to promoting tailored interventions for specific stages of recovery. The importance of referring to lived experience when trying to understand and develop better treatments for mental illness has been well established. This study contributes to the growing body of research that includes the voice of the person with mental illness offering not only a vivid portrayal of life with mental health issues but also an understanding of the trajectory to recovery.
Tendencies for Comparing Up and Down: An Examination of the Directional Subscales of the Iowa-Netherlands Comparison Orientation Measure

Abstract People vary in their individual tendencies to compare to others—referred to as social comparison orientation (SCO). Researchers have heretofore developed and validated a scale to assess SCO—the Iowa-Netherlands Comparison Orientation Measure (INCOM). The standard INCOM assesses non-directional comparisons, but not directional comparisons to better- and worse-off others. The goal of the present research was to examine the factor structure and validity of directional (and non-directional) comparison tendencies using the expanded INCOM. Across four archival studies and one pre-registered study using student and non-student samples, we provide evidence for 1) a 3-factor structure for the INCOM with non-directional, directional-upward, and directional-downward SCO dimensions, 2) inter-correlations among the SCO dimensions suggesting convergent validity of the directional scales, 3) greater endorsement of non-directional, then directional-upward, and directional-downward SCO, 4) lower SCO among older individuals and members of racial/ethnic minority groups, and 5) strong and consistent associations of directional-upward SCO with well-being and affect, appearance beliefs (e.g., body satisfaction), social emotions (e.g., envy), and agency-related motivations and consequences in interpersonal contexts, but smaller and less consistent associations of non-directional and directional-downward SCO with outcomes (with notable exceptions). Taken together, this research indicates that SCO is a multi-faceted individual difference variable.
Model reduction and pollution source identification from remote sensing data

We consider a source identification problem related to determination of contaminant source parameters in lake environments using remote sensing measurements. We carry out a numerical example case study in which we employ the statistical inversion approach for the determination of the source parameters. In the simulation study a pipeline breaks on the bottom of a lake and only low-resolution remote sensing measurements are available. We also describe how model uncertainties and especially errors that are related to model reduction are taken into account in the overall statistical model of the system. The results indicate that the estimates may be heavily misleading if the statistics of the model errors are not taken into account.
Predictors of Subsidence and its Clinical Impact After Expandable Cage Insertion in Minimally Invasive Transforaminal Interbody Fusion

Study Design. Retrospective review of prospectively collected multisurgeon data. Objective. Examine the rate, clinical impact, and predictors of subsidence after expandable minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) cage. Summary of Background Data. Expandable cage technology has been adopted in MI-TLIF to reduce the risks and optimize outcomes. Although subsidence is of particular concern when using expandable technology as the force required to expand the cage can weaken the endplates, its rates, predictors, and outcomes lack evidence. Materials and Methods. Patients who underwent 1 or 2-level MI-TLIF using expandable cages for degenerative lumbar conditions and had a follow-up of >1 year were included. Preoperative and immediate, early, and late postoperative radiographs were reviewed. Subsidence was determined if the average anterior/posterior disc height decreased by >25% compared with the immediate postoperative value. Patient-reported outcomes were collected and analyzed for differences at the early (<6 mo) and late (>6 mo) time points. Fusion was assessed by 1-year postoperative computed tomography. Results. One hundred forty-eight patients were included (mean age, 61 yr, 86% 1-level, 14% 2-level). Twenty-two (14.9%) demonstrated subsidence. Although statistically not significant, patients with subsidence were older, had lower bone mineral density, and had higher body mass index and comorbidity burden. Operative time was significantly higher (P = 0.02) and implant width was lower (P < 0.01) for subsided patients. Visual analog scale-leg was significantly lower for subsided patients compared with nonsubsided patients at a >6 months time point. Long-term (>6 mo) patient-acceptable symptom state achievement rate was lower for subsided patients (53% vs. 77%), although statistically not significant (P = 0.065). No differences existed in complication, reoperation, or fusion rates. Conclusions. Of the patients, 14.9% experienced subsidence predicted by narrower implants. Although subsidence did not have a significant impact on most patient-reported outcome measures and complication, reoperation, or fusion rates, patients had lower visual analog scale-leg and patient-acceptable symptom state achievement rates at the >6-month time point. Level of Evidence. Level 4.
Associations of intimate partner violence and maternal comorbidities: a cross-sectional analysis of the Pregnancy Risk Assessment Monitoring System

Abstract Context Intimate partner violence (IPV) occurs when an intimate partner inflicts physical, sexual, and/or emotional assault with coercive control and is a traumatic experience with repercussions that can be exacerbated when a woman is pregnant. While screening for IPV during pregnancy is recommended to occur regardless of risk, less than 50% of pregnant women are screened. Objectives Identifying clinical factors commonly associated with IPV during pregnancy may improve screening rates, thus our primary objective was to examine associations between IPV and maternal comorbidities. Methods We conducted a cross-sectional analysis of the Pregnancy Risk Assessment Monitoring System (PRAMS) Phase 8 spanning 2016 through 2019. Bivariate and multivariable logistic regression was utilized to calculate adjusted odds ratios (AORs) to determine associations between IPV and diabetes, anxiety, hypertension, depression, asthma, polycystic ovary syndrome (PCOS), and thyroid disease. Results More than 40% of women experiencing IPV reported a history of depression or anxiety. The occurrence of IPV was higher among women with depression (AOR 3.48, CI 3.14–3.85), anxiety (AOR 2.98, CI 2.64–3.37), hypertension (AOR 1.21, CI 1.02–1.44), and asthma (AOR 1.37; CI 1.17–1.59) than women without those respective conditions, but not among diagnoses of diabetes, PCOS, or thyroid disorders. Conclusions Our findings show that pregnant individuals reporting having experienced IPV were more likely to report having certain comorbidities compared to those who did not report experiencing IPV. Given the low rates of screening, knowing clinically relevant associations may increase screening sensitivity among clinicians and, in turn, increase the likelihood that individuals experiencing IPV receive supportive care.
Environment Enrichment Facilitates Long-Term Memory Consolidation through Behavioral Tagging

Abstract The behavioral tagging (BT) hypothesis provides crucial insights into the mechanism of long-term memory (LTM) consolidation. Novelty exposure in BT is a decisive step in activating the molecular machinery of memory formation. Several studies have validated BT using different neurobehavioral tasks; however, the novelty given in all studies is open field (OF) exploration. Environment enrichment (EE) is another key experimental paradigm to explore the fundamentals of brain functioning. Recently, several studies have highlighted the importance of EE in enhancing cognition, LTM, and synaptic plasticity. Hence, in the present study, we investigated the effects of different types of novelty on LTM consolidation and plasticity-related protein (PRP) synthesis using the BT phenomenon. Novel object recognition (NOR) was used as the learning task for rodents (male Wistar rats), while OF and EE were two types of novel experiences provided to the rodents. Our results indicated that EE exposure efficiently leads to LTM consolidation through the BT phenomenon. In addition, EE exposure significantly enhances protein kinase Mζ (PKMζ) synthesis in the hippocampus region of the rat brain. However, the OF exposure did not lead to significant PKMζ expression. Further, our results did not find alterations in BDNF expression after EE and OF exposure in the hippocampus. Hence, it is concluded that different types of novelty mediate the BT phenomenon up to the same extent at the behavioral level. However, the implications of different novelties may differ at molecular levels.