Miracle-dz/UniFAR-FTUs huggingface dataset:
Success factors for indigenous wildlife-based enterprise in Northern Australia

Access to land and resources has not, in itself, been sufficient for improving the wellbeing of Indigenous people living in remote northern Australia. Though exceedingly valuable in other ways, much of the Indigenous estate has limited potential for market-based economic development. However, many Indigenous Australians have become increasingly interested in using natural resources commercially for livelihoods development. This thesis investigates the key factors of success for one such market-based opportunity: Indigenous wildlife-based enterprise. Commercial uses of wildlife have the potential to harness assets available to Aboriginal people living in remote northern Australia for the enhancement of their livelihoods. Indeed, many Indigenous Australians are already using wildlife commercially to supplement their livelihoods, to expand natural resource management capacity and to enhance their ability to perform cultural obligations on country. To investigate factors of success, a set of three case studies of successful Indigenous wildlife-based enterprises were constructed using a grounded theory approach. Research was conducted during nine field trips to three sites: Broome/Dampier Peninsula (WA); Bulman (NT) and Maningrida (NT). These field trips took place between November 2008 and January 2011. A total of 55 days was spent in the field conducting observations and recording interviews with 32 research participants. These qualitative data were analysed using standard coding techniques. Seven key factors were identified as underpinning the success of the enterprises investigated. They were: the resource base; minimal anti-use sentiment; demonstrable sustainability; markets; access; social capital; and supportive organisations and formal institutions. These case studies provide examples of natural resource-based enterprises that have allowed Indigenous people to engage in market-based economic activity in remote northern Australia. The findings of this thesis will be of interest to Indigenous people and communities, development practitioners, policy-makers and natural resource managers working in the fields of Indigenous livelihood development and the sustainable use of wildlife.
Energy from the desert : feasibility of very large scale photovoltaic power generation (VLS-PV) systems

Foreword * Preface * Task 8 Participants * List of Contributors * Acknowledgements * List of Figures and Tables * List of Acronyms and Abbreviations * Executive Summary * Introduction * The Mediterranean Region: Case Study of Very Large Scale Photovoltaics * The Middle East Region: A Top Down Approach for Introducing VLS-PV Plants * The Asian Region: Project Proposals of VLS-PV on the Gobi Desert * The Oceania Region: Realizing a VLS-PV Power Generation System at Perenjori * Desert Region Community Development * Conclusions and Recommendations * Appendix A: Case Studies of VLS-PV Systems in Deserts * Appendix B: Future Possibilities Towards World Major Energy
Genome-wide association for major depressive disorder

Sullivan et al. Page 3 Mol Psychiatry. Author manuscript; available in PMC 2009 October 1. N IH PA Athor M anscript N IH PA Athor M anscript N IH PA Athor M anscript Major depressive disorder (MDD) is a common complex trait with enormous public health significance. As part of the Genetic Association Information Network (GAIN) initiative of the US Foundation for the National Institutes of Health, we conducted a genomewide association study of 435,291 SNPs genotyped in 1,738 MDD cases and 1,802 controls selected to be at low liability for MDD. Eleven of the top 200 signals localized to a 167 kb region overlapping the gene piccolo (PCLO, whose protein product localizes to the cytomatrix of the presynaptic active zone and plays an important role in monoaminergic neurotransmission in the brain) with p-values of 7.7×10−7 for rs2715148 and 1.2×10−6 for rs2522833. We undertook replication of SNPs in this region in 5 independent samples (6,079 MDD independent cases and 5,893 controls) but no SNP exceeded the replication significance threshold when all replication samples were analyzed together. However, there was heterogeneity in the replication samples, and secondary analysis of the original sample with the sample of greatest similarity yielded p=6.4×10−8 for the non-synonymous SNP rs2522833 that gives rise to a serine to alanine substitution near a C2 calcium-binding-domain of the PCLO protein. With the integrated replication effort, we present a specific hypothesis for further studies.
Acceptability of Personal Sensing Among People With Alcohol Use Disorder: Observational Study

Background Personal sensing may improve digital therapeutics for mental health care by facilitating early screening, symptom monitoring, risk prediction, and personalized adaptive interventions. However, further development and the use of personal sensing requires a better understanding of its acceptability to people targeted for these applications. Objective We aimed to assess the acceptability of active and passive personal sensing methods in a sample of people with moderate to severe alcohol use disorder using both behavioral and self-report measures. This sample was recruited as part of a larger grant-funded project to develop a machine learning algorithm to predict lapses. Methods Participants (N=154; n=77, 50% female; mean age 41, SD 11.9 years; n=134, 87% White and n=150, 97% non-Hispanic) in early recovery (1-8 weeks of abstinence) were recruited to participate in a 3-month longitudinal study. Participants were modestly compensated for engaging with active (eg, ecological momentary assessment [EMA], audio check-in, and sleep quality) and passive (eg, geolocation, cellular communication logs, and SMS text message content) sensing methods that were selected to tap into constructs from the Relapse Prevention model by Marlatt. We assessed 3 behavioral indicators of acceptability: participants’ choices about their participation in the study at various stages in the procedure, their choice to opt in to provide data for each sensing method, and their adherence to a subset of the active methods (EMA and audio check-in). We also assessed 3 self-report measures of acceptability (interference, dislike, and willingness to use for 1 year) for each method. Results Of the 192 eligible individuals screened, 191 consented to personal sensing. Most of these individuals (169/191, 88.5%) also returned 1 week later to formally enroll, and 154 participated through the first month follow-up visit. All participants in our analysis sample opted in to provide data for EMA, sleep quality, geolocation, and cellular communication logs. Out of 154 participants, 1 (0.6%) did not provide SMS text message content and 3 (1.9%) did not provide any audio check-ins. The average adherence rate for the 4 times daily EMA was . 80. The adherence rate for the daily audio check-in was . 54. Aggregate participant ratings indicated that all personal sensing methods were significantly more acceptable (all P<.001) compared with neutral across subjective measures of interference, dislike, and willingness to use for 1 year. Participants did not significantly differ in their dislike of active methods compared with passive methods (P=.23). However, participants reported a higher willingness to use passive (vs active) methods for 1 year (P=.04). Conclusions These results suggest that active and passive sensing methods are acceptable for people with alcohol use disorder over a longer period than has previously been assessed. Important individual differences were observed across people and methods, indicating opportunities for future improvement.
Status quo on identified transformation products of organic ultraviolet filters and their persistence

Organic micropollutants of concern—including organic UV filters (UVF)—are getting increasing attention. Personal care products such as sunscreens or cosmetic articles often contain large quantities of UVF. These substances enter the environment either directly (during outdoor activities) or indirectly (via sewages from households). Therefore, the removal or degradation of UVF by natural or technical treatment processes is important to understand. UVF are often incompletely removed and transformed to side products of incomplete mineralization by abiotic and biotic processes. An extensive overview on transformation products (TPs) is essential to systematically identify knowledge gaps and to derive research needs. While there are many reviews on the UVF themselves, the number of reviews which focus on their TPs is limited. Consequently, this review gives an overview on the latest findings regarding TPs of UVF. In this publication, known TPs of UVF, which were formed during abiotic and biotic processes, are reviewed. Target substances were defined and a literature database was reviewed for studies on TPs of the target substances. The first list of studies was shortened stepwise, thus generating a final list of studies which contained only the relevant studies. Since biodegradation is one of the most important pathways for removal of organic compounds from the environment, this review presents an overview on known TPs of organic UVF and their biodegradability, which determines their environmental fate. In this way, all identified TPs of UVF were listed and checked for information on their biodegradability. A total of 2731 records of studies were assessed. Forty‐two studies, which assessed 46 processes that lead to the formation of identified TPs, were included in this review. One hundred and seventyseven different TPs resulting from 11 different UVF were identified. Little to no data on the biodegradability was found for TPs. This indicates a severe lack of data on the biodegradability of TPs of organic UVF substances. Since most TPs lack information on biodegradability, further research should provide information on both—identity and biodegradability—of formed TPs to be able to assess their hazardousness for the environment.
Equity-specific effects of interventions to promote physical activity among middle-aged and older adults: Development of a collaborative equity-specific re-analysis strategy

: Reducing social inequalities in physical activity (PA) has become a priority for public health. However, evidence concerning the impact of interventions on inequalities in PA is scarce. This study aims to develop and test the application of a strategy for re-analyzing equity-speciﬁc e ﬀ ects of existing PA intervention studies in middle-aged and older adults, as part of an international interdisciplinary collaboration. This article aims to describe (1) the establishment and characteristics of the collaboration; and (2) the jointly developed equity-speciﬁc re-analysis strategy as a ﬁrst result of the collaboration. To develop the strategy, a collaboration based on a convenience sample of eight published studies of individual-level PA interventions among the general population of adults aged ≥ 45 years was initiated (UK, n = 3; The Netherlands, n = 3; Belgium, n = 1; Germany, n = 1). Researchers from these studies participated in a workshop and subsequent e-mail correspondence. The developed strategy will be used to investigate social inequalities in intervention adherence, dropout, and e ﬃ cacy. This will allow for a comprehensive assessment of social inequalities within intervention beneﬁts. The application of the strategy within and beyond the collaboration will help to extend the limited evidence regarding the e ﬀ ects of interventions on social inequalities in PA among middle-aged and older adults.
Use of poxvirus display to select antibodies specific for complex membrane antigens

ABSTRACT Antibody discovery against complex antigens is limited by the availability of a reproducible pure source of concentrated properly folded antigen. We have developed a technology to enable direct incorporation of membrane proteins such as GPCRs and into the membrane of poxvirus. The protein of interest is correctly folded and expressed in the cell-derived viral membrane and does not require any detergents or refolding before downstream use. The poxvirus is selective in which proteins are incorporated into the viral membrane, making the antigen poxvirus an antigenically cleaner target for in vitro panning. Antigen-expressing virus can be readily purified at scale and used for antibody selection using any in vitro display platform.
6‐Shogaol prevents benzo (A) pyrene‐exposed lung carcinogenesis via modulating PRDX1‐associated oxidative stress, inflammation, and proliferation in mouse models

In this study, we have investigated the chemopreventive role of 6‐shogaol (6‐SGL) on benzopyrene (BaP) exposed lung carcinogenesis by modulating PRDX1‐associated oxidative stress, inflammation, and proliferation in Swiss albino mouse models. Mice were exposed to BaP (50 mg/kg b.wt) orally twice a week for four consecutive weeks and maintained for 16 weeks, respectively. 6‐SGL (30 mg/kg b.wt) were orally administered to mouse 1 h before BaP exposure for 16 weeks. After the experiment's termination, 6‐SGL (30 mg/kg b.wt) prevented the loss in body weight, increased lung weight, and the total number of tumors in the mice. Moreover, we observed that 6‐SGL treatment reverted the activity of BaP‐induced lipid peroxidation and antioxidants in mice. Also, 6‐SGL impeded the phosphorylation of MAPK family proteins such as Erk1, p38, and Jnk1 in BaP‐exposed mice. PRDX1 is an essential antioxidant protein that scavenges toxic radicals and enhances several antioxidant proteins. Overexpression of PRDX1 substantially inhibits MAPKs, proliferation, and inflammation signaling axis. Hence, PRDX1 is thought to be a novel targeting protein for preventing BaP‐induced lung cancer. In this study, we have obtained the 6‐SGL treatment in a mouse model that reverted BaP‐induced depletion of PRDX1 expression. Moreover, pretreatment of 6‐SGL (30 mg/kg b.wt) significantly inhibited enhanced proinflammatory cytokines (TNF‐α, IL‐6, IL‐β1, IL‐10) and proliferative markers (Cyclin‐D1, Cyclin‐D2, and PCNA) in BaP‐exposed mice. The histopathological studies also confirmed that 6‐SGL effectively protected the cells with less damage. Thus, the study demonstrated that 6‐SGL could be a potential phytochemical and act as a chemopreventive agent in BaP‐induced lung cancer by enhancing PRDX1 expression.
The jugular venous‐to‐arterial PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_{\mathrm{2}}}}}$ difference during rebreathing and end‐tidal forcing: Relationship with cerebral perfusion

We examined two assumptions of the modified rebreathing technique for the assessment of the ventilatory central chemoreflex (CCR) and cerebrovascular CO2 reactivity (CVR), hypothesizing: (1) that rebreathing abolishes the gradient between the partial pressures of arterial and brain tissue CO2 [measured via the surrogate jugular venous PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_{\mathrm{2}}}}}$ and arterial PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_{\mathrm{2}}}}}$ difference (Pjv‐aCO2)] and (2) rebreathing eliminates the capacity of CVR to influence the Pjv‐aCO2 difference, and thus affect CCR sensitivity. We also evaluated these variables during two separate dynamic end‐tidal forcing (ETF) protocols (termed: ETF‐1 and ETF‐2), another method of assessing CCR sensitivity and CVR. Healthy participants were included in the rebreathing (n = 9), ETF‐1 (n = 11) and ETF‐2 (n = 10) protocols and underwent radial artery and internal jugular vein (advanced to jugular bulb) catheterization to collect blood samples. Transcranial Doppler ultrasound was used to measure middle cerebral artery blood velocity (MCAv). The Pjv‐aCO2 difference was not abolished during rebreathing (6.2 ± 2.6 mmHg; P < 0.001), ETF‐1 (9.3 ± 1.5 mmHg; P < 0.001) or ETF‐2 (8.6 ± 1.4 mmHg; P < 0.001). The Pjv‐aCO2 difference did not change during the rebreathing protocol (−0.1 ± 1.2 mmHg; P = 0.83), but was reduced during the ETF‐1 (−3.9 ± 1.1 mmHg; P < 0.001) and ETF‐2 (−3.4 ± 1.2 mmHg; P = 0.001) protocols. Overall, increases in MCAv were associated with reductions in the Pjv‐aCO2 difference during ETF (−0.095 ± 0.089 mmHg cm−1 s−1; P = 0.001) but not during rebreathing (−0.028 ± 0.045 mmHg · cm−1 · s−1; P = 0.067). These findings suggest that, although the Pjv‐aCO2 is not abolished during any chemoreflex assessment technique, hyperoxic hypercapnic rebreathing is probably more appropriate to assess CCR sensitivity independent of cerebrovascular reactivity to CO2.
Sodium Tanshinone IIA Sulfonate Attenuates Tumor Oxidative Stress and Promotes Apoptosis in an Intermittent Hypoxia Mouse Model

Objective: Intermittent hypoxia, a significant feature of obstructive sleep apnea, has pro-tumorigenic effects. Here, we investigated the effect of sodium tanshinone IIA sulfonate on oxidative stress and apoptosis in a mouse model of Lewis lung carcinoma with intermittent hypoxia. Methods: Mice were randomly assigned to normoxia (control), normoxia plus sodium tanshinone IIA sulfonate (control + sodium tanshinone IIA sulfonate), intermittent hypoxia, and intermittent hypoxia + sodium tanshinone IIA sulfonate groups. Intermittent hypoxia administration lasted 5 weeks in the intermittent hypoxia groups. Lewis lung carcinoma cells were injected into the right flank of each mouse after 1 week of intermittent hypoxia exposure. Sodium tanshinone IIA sulfonate was injected intraperitoneally in the control + sodium tanshinone IIA sulfonate and intermittent hypoxia + sodium tanshinone IIA sulfonate groups. Tumor oxidative stress was evaluated by detection of malondialdehyde and superoxide dismutase. The apoptosis of tumor cells was evaluated by the terminal deoxynucleotidyl transferase dUTP nick-end labeling assay as well as by Western blot analysis of B-cell lymphoma 2-associated X protein and cleaved caspase-3 expression. Additionally, the expression of hypoxia-induced factor-1α, nuclear factor erythroid 2-related factor 2, and nuclear factor kappa B was also evaluated by Western blot. Results: Compared with the control group, the intermittent hypoxia treatment significantly increased Lewis lung carcinoma tumor growth and oxidative stress (serum malondialdehyde) but decreased serum levels of SOD and pro-apoptotic markers (terminal deoxynucleotidyl transferase dUTP nick-end labeling staining, B-cell lymphoma 2-associated X protein, and cleaved caspase-3). These changes were significantly attenuated by intraperitoneal injection of sodium tanshinone IIA sulfonate. Lower nuclear factor erythroid 2-related factor 2 and higher nuclear factor kappa B levels in the intermittent hypoxia group were clearly reversed by sodium tanshinone IIA sulfonate treatment. In addition, sodium tanshinone IIA sulfonate administration decreased the high expression of hypoxia-induced factor-1α induced by intermittent hypoxia. Conclusion: Intermittent hypoxia treatment resulted in high oxidative stress and low apoptosis in Lewis lung carcinoma–implanted mice, which could be attenuated by sodium tanshinone IIA sulfonate administration possibly through a mechanism mediated by the nuclear factor erythroid 2-related factor 2/nuclear factor kappa B signaling pathway.
The features of cerebral permeability and perfusion detected by dynamic contrast-enhanced magnetic resonance imaging with Patlak model in relapsing–remitting multiple sclerosis

Objective: To investigate the features of cerebral permeability and perfusion detected by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with Patlak model in relapsing–remitting multiple sclerosis (RRMS) and their correlations with Expanded Disability Status Scale (EDSS) scores and disease duration. Patients and methods: Twenty-seven RRMS patients underwent conventional MRI and DCE-MRI with 3.0 T magnetic resonance scanner were enrolled in the study. A Patlak model was used to quantitatively measure MRI biomarkers, including volume transfer constant (K trans ), fractional plasma volume (V p ), cerebral blood flow (CBF), and cerebral blood volume (CBV). The correlations of MRI biomarkers with EDSS scores and disease duration were analyzed. Results: The MRI biomarkers K trans , V p , CBF, and CBV of contrast-enhancing (CE) lesions were significantly higher ( P , 0.05) than those of non-enhancing (NE) lesions and normal-appearing white matter (NAWM) regions. The skewness and kurtosis of K trans values in CE lesions were significantly higher ( P , 0.05) than that of NE lesions. No significant correlation was found among the biomarkers with EDSS scores and disease duration ( P . 0.05). Conclusion: Our study demonstrated the abnormalities of permeability and perfusion characteristics in multiple sclerosis (MS) lesions and NAWM regions by DCE-MRI with Patlak model. The K trans , V p , CBF, and CBV of CE lesions were significantly higher than that of NE lesions, but these MRI biomarkers did not associate with the severity and duration of the disease. The skewness and kurtosis of K trans value in CE lesions were significantly higher than that in NE lesions, indicating that these parameters of K trans histogram can be used to distinguish the pathology of MS lesions. MRI biomarkers, including K trans , V p , CBF, and CBV. The K trans and V p reflect the permeability characteristics of microcirculation, while CBF and CBV reflect cerebral perfusion. The artificial color mappings were performed, and the correlation among imaging biomarkers, EDSS scores, and disease duration were also analyzed. The coefficient of skewness is a measure for the degree of symmetry in the variable distribution. If skewness = 0, it represents normal distribution. If skewness is , 0, it represents the distribution skewed to the left, otherwise to the right. The kurtosis reflects a heavy- or light-tailed distribution. The kurtosis for a standard normal distribution is three. CE and NE lesions were measured on postcontrast T1-weighted images and precontrast FLAIR respectively. NAWM regions