Miracle-dz/UniFAR-FTUs huggingface dataset:
Sleep Quality After Quetiapine Augmentation in Patients With Treatment-Resistant Depression and Personality Disorders

Abstract Purpose/Background Quetiapine is a first-line augmenting agent for treatment-resistant depression (TRD) and is used off-label in insomnia. Quetiapine and its active metabolite norquetiapine act mostly on 5-HT2A, 5-HT2C, H1, and D2 as antagonists and on 5-HT1A as partial agonists. Patients with TRD often have comorbid personality disorder (PD), and evidence suggests an association between sleep disturbance and recovery among patients with PD. Here, we aimed to evaluate the effects of quetiapine on sleep in TRD patients with and without PD (PD+/PD−). Methods/Procedures We reviewed health records of 38 patients with TRD (20 TRD/PD+) who had been treated with a pharmacotherapy regimen including quetiapine. Clinical outcomes were determined by comparing changes in sleep items of the Hamilton Depression Rating Scale at the beginning (T0) and after 3 months of an unchanged treatment (T3). Findings/Results Patients with TRD/PD+ and TRD/PD− taking quetiapine showed significant improvement in sleep items from T0 to T3 (P < 0.001, ηp2 ≥ 0.19). There was a significant personality × time interaction for sleep-maintenance insomnia (P = 0.006, ηp2 = 0.23), with TRD/PD+ showing a greater improvement at T3 compared with TRD/PD− (P = 0.01). While exploring other sleep items, no personality × time interaction was found. In the TRD/PD− group, improvement in sleep items was associated with an overall improvement in depressive symptoms (r = 0.55, P = 0.02). Implications/Conclusions Quetiapine induced greater improvements in sleep-maintenance insomnia among TRD/PD+ patients than TRD/PD−. These findings suggest quetiapine could have a therapeutic role for insomnia in PD underscoring a distinct underlying neurobiological mechanism of sleep disturbance in people living with PD.
Chapter 12 - Human settlements, infrastructure and spatial planning

Urbanization is a process that involves simultaneous transitions and transformations across multiple dimensions, including demographic, economic, and physical changes in the landscape. Each of these dimensions presents different indicators and definitions of urbanization. The chapter begins with a brief discussion of the multiple dimensions and definitions of urbanization, including implications for GHG emissions accounting, and then continues with an assessment of historical, current, and future trends across different dimensions of urbanization in the context of GHG emissions (12.2). It then discusses GHG accounting approaches and challenges specific to urban areas and human settlements. In Section 12.3, the chapter assesses the drivers of urban GHG emissions in a systemic fashion, and examines the impacts of drivers on individuals sectors as well as the interaction and interdependence of drivers. In this section, the relative magnitude of each driver's impact on urban GHG emissions is discussed both qualitatively and quantitatively, and provides the context for a more detailed assessment of how urban form and infrastructure affect urban GHG emissions (12.4). Here, the section discusses the individual urban form drivers such as density, connectivity, and land use mix, as well as their interactions with each other. Section 12.4 also examines the links between infrastructure and urban form, as well as their combined and interacting effects on GHG emissions. Section 12.5 identifies spatial planning strategies and policy instruments that can affect multiple drivers, and Section 12.6 examines the institutional, governance, and financial requirements to implement such policies. Of particular importance with regard to mitigation potential at the urban or local scale is a discussion of the geographic and administrative scales for which policies are implemented, overlapping, and / or in conflict. The chapter then identifies the scale and range of mitigation actions currently planned and / or implemented by local governments, and assesses the evidence of successful implementation of the plans, as well as barriers to further implementation (12.7). Next, the chapter discusses major co-benefits and adverse side-effects of mitigation at the local scale, including opportunities for sustainable development (12.8). The chapter concludes with a discussion of the major gaps in knowledge with respect to mitigation of climate change in urban areas (12.9).
The Release of Grape Pomace Phenolics from Alginate-Based Microbeads during Simulated Digestion In Vitro: The Influence of Coatings and Drying Method

Grape pomace is a byproduct of wineries and a sustainable source of bioactive phenolic compounds. Encapsulation of phenolics with a well-chosen coating may be a promising means of delivering them to the intestine, where they can then be absorbed and exert their health-promoting properties, including antioxidant, anti-inflammatory, anticancer, cardioprotective, and antimicrobial effects. Ionic gelation of grape pomace extract with natural coatings (sodium alginate and its combination with maltodextrins, gelatin, chitosan, gums Tragacanth and Arabic) was performed, and the resulting hydrogel microbeads were then air-, vacuum-, and freeze-dried to prevent spoilage. Freeze-drying showed advantages in preserving the geometrical parameters and morphology of the microbeads compared to other drying techniques. A good relationship was found between the physicochemical properties of the dried microbeads and the in vitro release of phenolics. Freeze-dried microbeads showed the highest cumulative release of phenols in the intestinal phase (23.65–43.27 mgGAE/gMB), while the most suitable release dynamics in vitro were observed for alginate-based microbeads in combination with gelatin, gum Arabic, and 1.5% (w/v) chitosan. The results highlight the importance of developing encapsulated formulations containing a natural source of bioactive compounds that can be used in various functional foods and pharmaceutical products.
Does the Order Matter? A Random Generative Way to Learn Label Hierarchy for Hierarchical Text Classification

Hierarchical Text Classification (HTC) is an essential and challenging task due to the difficulty of modeling label hierarchy. Recent generative methods have achieved state-of-the-art performance by flattening the local label hierarchy into a label sequence with a specific order. However, the order between labels does not naturally exist and the generation of the current label should incorporate the information in all other target labels. Moreover, the generative methods usually suffer from the error accumulation problem. To this end, we propose a new framework named sequence-to-label (Seq2Label) with a random generative way to learn label hierarchy for hierarchical text classification. Instead of using only one specific order, we shuffle the label sequence by a Label Sequence Random Shuffling (LSRS) mechanism so that a text will be mapped to several different order label sequences during the training phase. To alleviate the error accumulation problem, we further propose a Hierarchy-aware Negative Sampling (HNS) strategy with a negative label-aware loss to better distinguish target labels and negative labels. In this way, our model can capture the hierarchical and co-occurrence information of the target labels of each text. The experimental results on three benchmark datasets show that Seq2Label achieves state-of-the-art results.
Temporal Variation of Carbon Monoxide Concentration at Congested Urban Roadways Intersection

The carbon monoxide (CO) is dominant among major traffic emitted pollutants such as respirable suspended particulate matter (RSPM), oxides of nitrogen (NOx), volatile organic carbons(VOCs) and ozone (O3) etc. It is generated by automobiles due to incomplete combustion of the fuel. The vehicles that queue up at an intersection spend more time in idle driving mode generating more pollutant leading to higher pollutant concentrations. Therefore, the trends of average hourly CO concentrations at various locations of congested roadways intersection have been investigated. The four approach roads making intersection have been selected for the present study. CO monitoring has been carried out at 2 selected locations of each approach road. The CO concentration has been monitored from 8:00 AM to 8:00 PM at each location using portable online CO monitor. The average hourly CO concentrations data have been analyzed using MS excel spread sheet for each approach road. The average hourly concentration of monitored CO concentration at all receptors locations shows two peak CO concentration values (i.e., the morning peak and evening peak) throughout the monitoring programme (March to May, 2011). The comparison of monitored values of average 1 hourly CO concentration levels as well as 8 hourly average concentration levels of CO showed non compliance with the prescribed standards (4000 µg/m 3 average hourly and 2000 µg/m 3 average 8 hourly CO concentration). The temporal CO concentration at various approach roads making roadway intersection shows non-uniform. The highest CO concentration has been observed to be towards high rise building and vice-versa. The least CO concentration has been observed towards either low rise building or open area.
Estimation of the metabolisable energy requirements of feedlot light lambs and comparison with the U. S. National Research Council predictions

Abstract The aim of the present work was to compare the estimated metabolisable energy requirements (MER) of fattening light lambs raised in feedlot with the U. S. National Research Council (NRC) predictions. Body weight (BW) gain and feed intake were collected from 15 pens (7 lambs/pen) of Manchega male lambs under on-farm conditions over six weeks. The pens were randomly assigned to three dietary treatments (5 pens/treatment) consisting of three concentrates of different composition and barley straw. Feeds were offered for ad libitum consumption throughout the experimental period. Average daily metabolisable energy intake (MEI) was calculated on a weekly basis for each pen from the average daily consumption of concentrate and barley straw and their respective ME contents. Following, the average daily MER was predicted for each pen from the weekly average of both BW and BW gain, according to two models: One including the adjustment of ME for body maintenance (MEm) for the effect of level of MEI on visceral organ tissue energy use as described by NRC (Model 1), and the other excluding such adjustment (Model 2). Model 1 had no mean bias, and exhibited a higher concordance correlation coefficient and a lower underprediction, supporting the need for the upward adjustment of MEm in accordance with MEI to enhance the precision and accuracy of predicted MER. It was concluded that the NRC method was precise and accurate enough to support its application for calculating the MER of feedlot light lambs. HIGHLIGHTS A dataset comprising metabolisable energy (ME) intake and growth performance data of Manchega male lambs was utilised. The lambs’ ME requirements were predicted according to the U.S. National Research Council (NRC) methods. Our data agree with NRC predictions, supporting its use in feedlot Manchega lambs.
Evaluation of the Inhibitory Effect of Moringa oleifera Leaves Methanolic Extract against In Vitro Growth of Several Babesia Species and Theileria equi and the In Vivo Growth of Babesia microti

The current study evaluated the inhibitory effect of Moringa oleifera leaves methanolic extract (MOL) against the in vitro growth of Babesia bovis (B. bovis), B. caballi, B. bigemina, and Theileria equi (T. equi), as well as in vivo growth of B. microti in mice. Active principles of MOL extract were determined using liquid chromatography mass spectrometry (LC-MS). MOL's anti-piroplasm efficacy was assessed both in vitro and in vivo using the SYBR Green I fluorescence assay. Every 96 hours, the hematological parameters, including red blood cell count (RBCs; 104/UL), hemoglobin content (HGB; g/dl), and hematocrit percent (HCT; %), in the treated mice were monitored using a Celltac MEK6450 automated hematological analyzer. LC-MS of MOL revealed that the most abundant polyphenolic catechism found in the MOL extract was isoquercetin and rutin. MOL inhibited B. bovis, B. caballi, B. bigemina, and T. equi in vitro growth in a dose-dependent way, with IC50 values of 45.29 ± 6.14, 19.16 ± 0.45, 137.49 ± 16.07, and 9.29 ± 0.014 μg/ml, respectively. MOL's in vitro antibabesial activity was enhanced when administrated simultaneously with either diminazene aceturate (DA) or MMV665875 compound from malaria box. In mice infected by B. microti, a combination of MOL and a low dose of DA (12.5 mg·kg−1) resulted in a significant (P < 0.05) reduction in B. microti growth. These findings suggest that MOL is an effective herbal anti-piroplasm therapy, especially when combined with a low dosage of either DA or MMV665875.
Tailoring parenting styles and family-based interventions cross-culturally as an effective prevention strategy for youth substance use: a scoping review

Background: The challenge of substance use among youth continues to be a highly concerning public health issue across the globe. The notion that parenting lifestyles and family-based intervention can help in the prevention of adolescent substance use have received robust attention from policy makers, researchers’ clinicians and general public, nonetheless, there is scarcity of high quality evidence to support these concepts. Objective: To review available literature which assessed the effects of parenting styles and family-based interventions on the prevention of adolescent substance use. Methods: A scoping review of literature to identify studies published in English between 2012 and 2022 was conducted searching Scopus, MEDLINE, PsychInfo, and CINAHL databases focused on effects of parenting styles and family-based interventions in the prevention of adolescent substance use. Keywords of family-based intervention strategies and possible outcomes of parenting styles on youth substance use were coded from the results, discussion, or conclusion. Strategies were inductively categorized into themes according to the focus of the strategy. Results: A total of 47 studies, published between 2012 and 2022 in English language included. Narrative synthesis illustrated that parental involvement, restriction of mature-rated content, parental monitoring, authoritative parenting styles, and parental support and knowledge can help in the prevention of adolescent substance use. On the contrary, poor parent-child bonding, overprotection, permissive parenting, parental frustrations, authoritarian and harsh parenting styles promoted adolescent substance use disorders. Proximal risk factors like peer influence, previous use of other substances, and risky behaviours had more effect than just parenting styles. Culturally tailored family-based intervention strategies such as “Preventive Parenting”, “Parent Training”, and “Parent Involvement”, with focus on “Technology Assisted Intervention”, particularly “SMART “(Substance Misuse among Adolescents in Residential Treatment) are found as effective family-based intervention strategies to mitigate substance use in youth. Conclusion: Culturally tailored family-based behavioural strategies psychosocial intervention strategies can be considered of the most effective strategies to prevent substance use disorders in youth.
Interaction entre la dermatologie et l’ophtalmologie : méta-analyse et recension systématique des écrits sur la lumière pulsée intense utilisée pour traiter le dysfonctionnement des glandes de Meibomius

Objectifs : Examiner, au moyen d’une méta-analyse, l’efficacité de la thérapie à lumière pulsée intense dans le traitement des symptômes de la sécheresse oculaire. Méthodologie : Cette étude a été réalisée en suivant la grille PRISMA. Les sources documentaires consultées comprennent MEDLINE, Embase, la bibliothèque Cochrane et des résumés de réunions de la SCO, d’ARVO, de l’American Academy of Optometry et de l’American Academy of Ophthalmology. Les articles ont subi trois étapes de tri avant l’extraction des données et la méta-analyse. Résultats : Au départ, nous avons recensé 495 études. Nous en avons retenu 52 après la présélection des titres et 23 après la présélection des résumés. Huit ont été sélectionnées en vue de l’extraction des données. La méta-analyse indique une augmentation importante du temps de rupture du film lacrymal (TRFL) après une thérapie à lumière pulsée (TLP) dans le suivi à moins d’un mois (différence moyenne standardisée [DMS]=1,45; IC :[0,33, 2,57]), le suivi à 1,5 ou 2 mois (DMS=2,08; IC : [1,14, 3,01]) et le suivi à 3 mois (DMS=3,28; IC :[2,78, 3,78]) et aucun changement significatif dans le TRFL dans le suivi à 6 mois (DMS=1,90; IC :[-0,18, 3,98]) ou le suivi à 12 mois des groupes d’une seule étude (DMS=0,0; IC :[-0,48, 0,48]). La méta-analyse indique également une augmentation importante des valeurs du test de Schirmer pendant la période de suivi à moins d’un mois (DMS = 0,91; IC : [0,50, 1,31]) et à six mois (DMS = 0,65; IC : [0,25, 1,04]) et aucun changement significatif des valeurs du test de Schirmer pendant la période de suivi à 1,5 ou 2 mois (DMS=0,41; IC :[-0,93, 1,75]). Conclusions : Les résultats indiquent une augmentation importante du TRFL jusqu’à 5 mois et aucun changement important à 6 mois après une TLP. Ils indiquent également une augmentation importante des valeurs du test de Schirmer au suivi à moins d’un mois et à six mois et aucun changement important de ces valeurs au suivi à un mois. Au bout du compte, la TLP semble prometteuse pour soulager les symptômes de la sécheresse oculaire, mais d’autres études comprenant des périodes de suivi plus longues sont nécessaires.
Grassland rehabilitation after alien invasive tree eradication: landscape degradation and sustainability in rural Eastern Cape

Rehabilitating grassland, a threatened biome, requires a comprehensive management approach that integrates the environmental, economic and social matters in sustaining this system. In the Eastern Cape of South Africa, three Quaternary catchments (QCs) (T35B, T12A & S50E) have been severely invaded by Invasive Alien Plants (IAPs) as well as altered by agrarian intensification and human development. Working for Water (WfW) Alien Plant Clearing Programme have been clearing IAPs in these catchments for the past twelve years. The current research aimed at establishing various degradation gradients occurring in the QCs. This was done by conducting land cover classification and change analysis over time, evaluating soil quality and assessing the success of the WfW program by quantifying the net primary production (NPP) and evapotranspiration (ET) trends on the cleared areas. A novel management scheme for decision makers, driver-pressure-state-impact-response (DPSIR) framework, was therefore suggested for managing these QCs sustainably. The soil analysis showed that phosphorus (P) levels are significantly different (P<0.05) between invaded, cleared and natural sites. High nitrogen (N) and pH were associated with Acacia proliferation in acidic soils. Object based image analysis (GEOBIA) was used for the land use land cover (LULC) classification using Landsat 8 OLI & TIRS imagery. LULC change analyses were carried out on two reference bases [National land cover (NLC) 2000 & Edited NLC (ENLC) 2000]. Land cover change analysis was facilitated by using a framework introducing labels to describe land cover change. Annual MODIS ET (MOD16)/NPP (MOD17) data were used to evaluate the rehabilitation progress in T12A using WfW clearing data. A DPSIR management framework, structuring the sustainable indicators at the QCs in a logical manner, was developed for decision and policy makers for dealing with management issues related to land use, water resources and soil quality management. The present research recommends that additional soil samples need to be collected for validation of soil nutrients status. Medium resolution Landsat imagery used for the LULC mapping provided accuracies of greater than 80%, but could not differentiate between invasive and indigenous trees. Hyperspectral or higher resolution imagery should be explored for mapping and delineating IAPs. Using coarse resolution MODIS products to model ET/NPP did not provide adequate detail of the cleared patches to describe the actual status of WfW clearings and their rehabilitation progress. Stellenbosch University https://scholar.sun.ac.za
Implementing Precision Health Care Program at Hospitals in Indonesia

Background: A precision healthcare approach is needed in the context of the healthcare system, especially as an effort to improve the self-management activities of diabetes patients. Accordingly, this study explores the perception of the possibility of implementing a precision healthcare program in hospitals through interviews with policymakers and health professionals. Methods: The purposive sampling via one-on-one, in-depth semi-structural interviews was conducted to collect the data in this study. The data saturation was achieved after interviewing 17 policymakers and health professionals in the selected hospitals. The participants discussed the possibility of a program being implemented in Indonesia and the challenges to implementing the program, as well as discovering the solutions. The narratives were analyzed by the Colaizzi phenomenological analytic method. Results: The three themes that were identified to illustrate the perception of the possibility of implementing precision health care programs at hospitals in Indonesia were as follows: 1) Precision health care for diabetes related to genetics, big data, and patient preference; 2) Barriers to implementing precision health care in Indonesian hospitals; and 3) The implementation of precision health care succeeded step by step. Conclusion: More time is needed to implement Indonesia’s precision healthcare concept. It requires time; however, applying the concept has great potential to be developed in reducing the risk of complications caused by diabetes mellitus in the future.
Lymphangioleiomyomatosis With Atypical Presentation Following Pneumothorax: A Case Report

Lymphangioleiomyomatosis (LAM) is a rare systemic disease that typically presents like cystic lung disease. High-resolution computed tomography (CT) is the recommended imaging technique, with cysts being the hallmark: typically multiple, well-circumscribed, thin-walled, with a variable diameter (usually <2 cm) and widespread in distribution. The gold standard for diagnosis is a biopsy. LAM should be considered in the differential diagnosis of cystic lung diseases. The authors report a case of LAM presenting with a pneumothorax, which due to its atypical imaging characteristics, mimicked another uncommon cystic disease. A multidisciplinary approach is crucial when dealing with presentations of rare diseases.