Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of preoperative tramadol, ibuprofen, ibuprofen/acetaminophen on the anaesthetic efficacy of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis.

The purpose of this double-blind clinical trial was to compare the effect of preoperative tramadol 50 mg, tramadol 100 mg, ibuprofen 600 mg, ibuprofen 600 mg/acetaminophen 1000 mg or placebo 60 min before the administration of inferior alveolar nerve blocks (IANB) of mandibular teeth in patients experiencing symptomatic irreversible pulpitis (SIP). Two hundred and fifty emergency patients diagnosed with SIP were randomly divided into five groups and received medications. Endodontic access was begun 15 min after completion of the IANB, and all patients had profound lip numbness. The Heft-Parker visual analogue scale was used to evaluate pain. Premedication with tramadol 100 mg significantly increased the success rate to 62% than the other groups (p < 0.05). The success rates of ibuprofen, ibuprofen/acetaminophen and tramadol 50 mg groups were not significantly different (p > 0.05). Premedication with tramadol 100 mg enhanced the anaesthetic success of IANB in mandibular molars with SIP.
Long-range Cooper pair splitting Enhanced by Supercurrent

We investigate crossed Andreev reflection (CAR) in a long-range normal metal-superconductor-normal metal junction, with the superconductor carrying a supercurrent along the junction. The energy splitting of quasiparticles in the superconductor induced by the supercurrent opens an energy window, in which CAR can occur over a distance between two normal leads much larger than the superconducting coherence length, with another nonlocal process of elastic cotunneling being completely quenched. As a result, CAR is significantly enhanced within the energy window, and dominates the nonlocal transport, which can be directly measured by the nonlocal differential conductance. The nonlocal entangled electron pairs generated via inverse CAR may belong to opposite or equal energy levels beyond the tunneling limit, and the total entanglement production rate within a unit bias voltage is solely determined by the CAR probability as $\mathcal{P}=2(1-A_2)A_2/h$. Our work indicates that a long-range Cooper pair splitter with high efficiency of nonlocal entanglement production can be implemented by simply driving a supercurrent.
of the nail-bed without

Candida parapsilosis is an emerging fungal pathogen that was once thought to be solely a colonizing organism. C. parapsilosis is increasingly becoming reported as the most common Candida species that causes onychomycosis. Clinical findings include typically severe dystrophy of the nail fold and plate as well as thickening and fragmentation of the plate, particularly in the distal plate. We present a unique case of C. parapsilosis infection of the nail bed without infection of the nail plate and with twenty-nail melanonychia
Opportunism in buyer–supplier exchange: a critical examination of the concept and its implications for theory and practice

Abstract Claims that opportunism is widespread in the process of buyer–supplier exchange are commonplace, but direct supporting evidence for such claims is largely absent from the relevant literature. This article offers a critique of the treatment of opportunism in supply chains by re-establishing the importance of guile in the concept and investigates existing published, empirical measures of buyer and supplier opportunistic behaviour. This article offers evidence that, despite the frequency with which the concept is discussed in the literature and applied in research and the emphasis given to the risks it generates for management, opportunism with guile between buyers and suppliers appears to be rare in practice. This article is the first critical assessment of the concept’s treatment in the Operations Management field, and it argues that practitioners are currently being poorly advised with respect to the phenomenon, as well as drawing conclusions for both practitioners and researchers that differ radically from the prevailing consensus on the subject.
risk factors for FeV 1 decline in mild COPD and high-risk populations

Background: Early diagnosis of COPD is often not achieved due to limited recognition and limited access to the pulmonary function test. Our hypothesis was that lung function decline may be different between populations with mild COPD and those who are at high risk and do not receive treatment. Patients and methods: Subjects with mild COPD and those from a high-risk COPD population were recruited from a community-based COPD epidemiological study after obtaining consent. Baseline clinical characteristics, symptom questionnaire, spirometry, low-dose computed tomography (LDCT) chest scan, and blood plasma biomarker data were collected initially and then 1 year later. Results: A total of 617 participants were recruited, and 438 eventually completed the first-year follow-up visit; 72 participants (46 males) were in the mild COPD group, and 225 participants (165 males) were in the high-risk group. The mean forced expiratory volume in the first second of expiration (FEV 1 ) decline in the mild COPD group was 129 mL, which was significantly higher than the 30 mL decline in the high-risk population group ( P = 0.005). Group category (odds ratio [OR] = 0.230) and COPD Assessment Test (CAT) score (OR = 9.912) were independent risk factors for an FEV 1 % predicted decline of . 15% for all participants. In the mild COPD group, patients with a higher CAT (OR = 5.310) and Emphysema Index (OR = 5.681) were associated with a FEV 1 % predicted decline of . 15% at the first-year follow-up. No factor showed a significantly predictive effect on FEV 1 decline in the high-risk COPD group. Conclusion: Group category was an independent influential factor associated with FEV 1 decline.
Across Estimates Using Contiguous

eScholarship provides open access, scholarly publishing services to the University of California and delivers a dynamic research platform to scholars worldwide. Abstract: We use policy discontinuities at state borders to identify the effects of minimum wages on earnings and employment in restaurants and other low-wage sectors. Our approach generalizes the case study method by considering all local differences in minimum wage policies between 1990 and 2006. We compare all contiguous county pairs in the U.S. that straddle a state border and find no adverse employment effects. We show that traditional approaches that do not account for local economic conditions tend to produce spurious negative effects due to spatial heterogeneities in employment trends that are unrelated to minimum wage policies. Our findings are robust to allowing for long term effects of minimum wage changes. Abstract— We use policy discontinuities at state borders to identify the effects of minimum wages on earnings and employment in restaurants and other low-wage sectors. Our approach generalizes the case study method by considering all local differences in minimum wage policies between 1990 and 2006. We compare all contiguous county-pairs in the United States that straddle a state border and ﬁnd no adverse employment effects. We show that traditional approaches that do not account for local economic conditions tend to produce spurious negative effects due to spatial heterogeneities in employment trends that are unrelated to minimum wage policies. Our ﬁndings are robust to allowing for long-term effects of minimum wage changes.
the CD94/NKG2C killer lectin-like receptor

Title: Imprint of human cytomegalovirus infection on the NK cell receptor repertoire. of in ABSTRACT Expression of activating (KLR) specific for HLA-E was analysed in peripheral blood lymphocytes (PBL) from healthy adult blood donors; the expression of other NK cell receptors (i.e. CD94/NKG2A, KIR, CD85j, CD161, NKp46, NKp30 and NKG2D) was also studied. Human cytomegalovirus (HCMV) infection, as well as the HLA-E and KIR genotypes were considered as potentially relevant variables associated with CD94/NKG2C expression. The proportion of NKG2C+ lymphocytes varied within a wide range ( (cid:1) 0.1-22.1%), and a significant correlation (r=0.83; p<0.001) between NKG2C+ NK and T cells was noticed. The HLA-E genotype and the number of activating KIR genes of the donors were not significantly related to the % of NKG2C+ lymphocytes. By contrast, a positive serology for HCMV, but not for other herpesviruses (i.e. Epstein-Barr and Herpes Simplex), turned out to be strongly associated (p<0.001) with increased proportions of NKG2C+ NK and T cells. Remarkably, the CD94/NKG2C+ population expressed lower levels of NCR (i.e. NKp30, NKp46) and included higher proportions of KIR+ and CD85j+ cells than CD94/NKG2A+ cells. Altogether, these data support that HCMV infection selectively shapes the NKR repertoire of NK and T cells from healthy carrier individuals. their autoreactivity HLA-E+
Long-term outcomes are poor in intravenous drug following

Previous studies of outcomes in people who inject drugs (PWID) with infective 36 endocarditis (IE) have often been retrospective, had a small sample size, the duration 37 of follow-up has been short and limited to patients who were operated on. PWID treated IE 01/01/2006 and 31/12/2016 were identified from a 41 prospectively collected database. PWID hospitalised with other infections acted as a 42 novel comparison group. Outcomes were all-cause mortality, cause of death, relapse, 43 recurrence and re-operation.
, the Agent of Lyme Disease burgdorferi Borrelia Inflammatory Response to Signaling through CD14 Attenuates the

Lyme disease is a chronic inﬂammatory disorder caused by the spirochetal bacterium, Borrelia burgdorferi . In vitro evidence suggests that binding of spirochetal lipoproteins to CD14, a pattern recognition receptor expressed on monocytes/macrophages and polymorphonuclear cells, is a critical requirement for cellular activation and the subsequent release of proinﬂammatory cytokines that most likely contribute to symptomatology and clinical manifestations. To test the validity of this notion, we assessed the impact of CD14 deﬁciency on Lyme disease in C3H/HeN mice. Contrary to an anticipated diminution in pathology, CD14 (cid:1) / (cid:1) mice exhibited more severe and persistent inﬂammation than did CD14 (cid:2) / (cid:2) mice. This disparity reﬂects altered gene regulation within immune cells that may engender the higher bacterial burden and serum cytokine levels observed in CD14 (cid:1) / (cid:1) mice. Comparing their in vitro stimulatory activity, live spirochetes, but not lysed organisms, were a potent CD14-independent stimulus of cytokine production, triggering an exaggerated response by CD14 (cid:1) / (cid:1) macrophages. Collectively, our in vivo and in vitro ﬁndings support the provocative notion that: 1) pattern recognition by CD14 is entirely dispensable for elaboration of an inﬂammatory response to B. burgdorferi , and 2) CD14-independent signaling pathways are inherently more destructive than CD14-dependent pathways. Continued study of CD14-independent signaling pathways may provide mechanistic
ADI-MRTD Algorithm for Periodic Structures Analysis

In this paper, a novel algorithm based on the alternating direction implicit (ADI) multiresolution time-domain (MRTD) method for periodic structure simulation is proposed. By applying the multiresolution analysis in accordance with wavelet theory, the spatial sampling rate of the conventional finite-difference time-domain (FDTD) is significantly reduced by the MRTD method. The ADI method is then used to remove the Courant-Friedrich-Levy (CFL) limit that the MRTD method experiences. The periodic boundary condition (PBC) is directly implemented in the time domain using a constant transverse wave-number (CTW) wave. Numerical results are presented to confirm the efficiency and accuracy of the proposed method.
PopulationClonal Expansion of the Bystander T Cell Feeding Antigen Occurs despite Normal Induction of Bystander Suppression by

The induction of bystander suppression, whereby the response against one Ag is suppressed when it is presented in the context of an Ag to which tolerance is already established, would be an important property of oral tolerance, because it would allow treatment of autoimmune and hypersensitivity responses where the initiating Ag is not known. Although bystander suppression has been described in oral tolerance, it is not known how its effects are mediated at the level of the bystander T cells. In addition, previous studies have not compared regimes in which Ag is fed in a tolerogenic or immunogenic manner, meaning that the possible effects of Ag competition have not been excluded. In this study we have used two populations of Ag-speciﬁc TCR transgenic CD4 (cid:1) T cells to examine the cellular basis of bystander suppression associated with oral tolerance in mice in vitro and in vivo. Our results show that bystander responses can be inhibited by feeding Ag and that these effects are more pronounced in mice fed protein in tolerogenic form than after feeding Ag with mucosal adjuvant. However, the expansion of the bystander-speciﬁc CD4 (cid:1) T cells is not inﬂuenced by the presence of oral tolerance. Thus, bystander suppression does not reﬂect clonal deletion or reduced clonal expansion of the bystander T cells, but may act by altering the functional differentiation of bystander T cells. The Journal of Immunology, 2004, 173: 6059–6064. transgenic CD4 (cid:1) T cells of different Ag speciﬁcities whose clonal expansion can be monitored directly. We show that feeding OVA in a tolerogenic regimen is associated with suppression of in vivo responses to a second Ag (hemagglutinin (HA) 3 ) when ad-ministered together with OVA at the time of challenge and that similar, but lesser, effects may occur in the presence of produc-tively primed T cells. However, the clonal expansion of the bystander HA-speciﬁc CD4 (cid:1) T cell population was not affected by the induction of oral tolerance, suggesting that bystander suppression alters the functional differentiation of naive T cells, rather than causes a quantitative difference in their clonal expansion.
A method of finding the initial approximation for Newton's method

The problem of modifying the classical Newton's method to calculate a localized solution of a system of non-linear equations with the aim of extending the range of convergence of iterations, of urgent importance in computational mathematics, is solved. Using the proposed modification, the conditions of convergence ofthe classical procedure are satisfied in the range of localization of the solution obtained. It is assumed that a simple isolated solution exists.
Video clip training improved emergency medicine residents’ interpretation ability of visual ejection fraction

Background: Information on cardiac contractility is very important in resuscitation of critically ill patients. However, the measurement of ejection fractions by echocardiography is very difficult to perform for non-cardiologists. We developed a video clip to train emergency medicine residents to measure visual ejection fraction and compared the improvement in their interpretation ability with that following the conventional training method. Objectives: Improvement of interpreting ability of vEF in short period. Methods: A total of 27 multicentre emergency medicine residents were recruited and divided into conventional training group (N = 13) and video clip training group (N = 14). Self-training was done for 1 week. Pre-test and post-test comprising 20 questions were used for evaluation, and scores and interpretation time were recorded. Results: The score of the video clip training group showed a statistically significant improvement in contrast to the conventional training group (the score of pre- and post-test, ±5% scoring method: correct answer; video clip training group, 5.4/20 to 10.4/20 (p < 0.001) versus conventional training group, 5.8/20 to 6.7/20 (p = 0.204)). Furthermore, there was a statistically significant reduction in the interpretation time (interpretation time of video clip training group, 417.7–358.8 s (p = 0.005) versus conventional training group, 416.8–411.5 s (p = 0. 497)). Conclusion: In the video clip training group, interpretation accuracy improved, and the interpretation time was shorter than that of the conventional training group. Based on these results, we conclude that improvement in the visual ejection fraction interpretation ability by emergency medicine residents can be expected.
THE Evaluation of Anthelmintic Potential of Alpinia galanga Aerial Parts

The aim of this study was to look into the anthelmintic potential of Alpinia galanga aerial parts extracts. The anthelmintic function of petroleum ether, methanolic, and aqueous extracts of Alpinia galanga aerial parts was tested using Indian adult earthworm Pheritima posthuma as experimental worms. Methanolic (50 and 100 mg/kg) and aqueous (100 mg/kg) extracts both demonstrated strong anthelmintic activity, with the methanolic extract being more effective than the aqueous extract. Paralysis was observed at (5.40±0.03416) and (2.40±0.03416) minutes in the case of methanolic extract at 50 mg/kg and 100 mg/kg concentrations, respectively, and death at (8.30±0.02887) and (6.40±0.04282) minutes. Paralysis was observed at (5.40±0.03416) and (2.40±0.03416) minutes in the case of methanolic extract at 50 mg/kg and 100 mg/kg concentrations, respectively, and death at (8.30±0.02887) and (6.40±0.04282) minutes. As compared to the standard compound, the methanolic extract of the aerial sections of Alpinia galanga displayed substantial anthelmintic activity in a dose-dependent
Research on the Degree of Correlation between Physiological Signals and Emotion Based on Multinomial Logistics Regression

Emotion recognition based on physiological signals has attracted many researchers in emotion computing abroad in recent years. The study found little research done on the degree of correlation between physiological signals and emotion. In this paper, from the perspective of a variety of physiological signals, degree of correlation was researched between the physiological signals and various emotions. Using the Augsburg University database in Germany and the Southeast University MPED database in China as sources for emotional physiology data. The data of ECG, respiratory signal and skin conductance signal under the emotions of joy, anger and sadness were taken as the research objects. Based on Augsburg University data and MPED data, Multinomial Logistics Regression method was used to complete the research and analysis of correlation degree. The results show that: To research the degree of correlation between physiological signals and emotion can improve the accuracy of emotion recognition. Using the same analysis method based on different databases (Augsburg University database and MPED), the degree of correlation is the same, namely, Joy and anger have the largest correlation with ECG signals, the smallest correlation with RSP, Sadness has the largest correlation with RSP, and the smallest correlation with ECG.
The impact of investor concerns on oil prices based on the perspective of literature analysis

From the perspective of literature analysis, using the Web of Science database, this paper statistically analyzes the literature on investor concerns and oil prices, and makes a literature review about the impact of investors' concerns on oil prices. This study found that since 2017, theory and practice circles for its attention gradually improved, especially the journal Energy Economics. Chinese funds, especially the National Natural Science Foundation of China, have given more support to research in this field. As to the impact of investors' attention on oil prices, most scholars have analyzed this issue from different angles, and believe that the former is one of the most important influencing factors of the latter.
Aplicação da metodologia DMAIC no gerenciamento de resíduos polímericos industriais

Currently, recycling of materials at the end of consumer goods’ working life has been in the spotlight in society, especially due to the environmental benefits generated by this practice. For this reason, recycling becomes a key fator within large companies, allowing them to generate revenue from processes’ waste while disposing that residue adequately. The goal of this Project is to search for a solution to increase the recycling index in a company located at the region know as “Vale do Paraíba” in Brazil. With that in mind, the DMAIC – a lean six sigma methodology for project management was used, and the wastes considered were polymeric waste consisting of polypropelene (PP) and polyethylene (PE), as well as pellets produced by extrusion. These materials were submitted to Differential Scanning Calorimetry (DSC) analysis for purposes of characterizing the wastes behavior under temperature variations and identifying the optimal parameters for extrusion. The results show that there is no change on the properties of the materials after the extrusion process, and the optimal point at which processing of the wastes becomes financially viable, allowing the prodution of pellets which can be used as raw material in other processes.
Analysis of Two Diverse Nursing Records Applications: Mixed Methods Approach

Abstract Introduction Poor adoption of electronic health records among healthcare workers can diminish their impact. Healthcare informatics solutions development should diligently acknowledge end-user needs. This study compares a user experience and perceived quality of the nursing process integration in two different applications for electronic documentation of the nursing care plan. Both applications were designed and tested in Slovenia. Methods In the first phase, final year undergraduate nursing students were recruited (n=73) and randomly assigned into two groups. Each group used one of the applications for a duration of five hours. A survey among students was conducted. In the second phase, additional students were recruited (n=40) and invited to participate in qualitative analysis of the unfavourably rated application. Results The modern, visually improved application was favourably rated by students in terms of all aspects of application usability. However, students reported a significant number of inadequacies regarding the nursing process methodology integration. On the contrary, the students using the poorly rated and visually outdated application reported no such concerns. Qualitative analysis of student reflections identified additional positive features of software design that were not detected in survey results analysis. Conclusion This study showed that a user-centred approach can be used to compare diverse electronic solutions. Detected discrepancies in findings using qualitative and quantitative analysis show the importance of integrating diverse research approaches for adequate evaluation of software solutions. Furthermore, this study design promotes empowerment of healthcare workers to participate in the development and critical evaluations of software solutions.