Miracle-dz/UniFAR-FTUs huggingface dataset:
A Nomogram To Predict The Overall Survival Of Breast Cancer Patients And Guide The Postoperative Adjuvant Chemotherapy In China

Purpose: We aim to construct a nomogram to predict breast cancer survival and guide postoperative adjuvant chemotherapy in China. Patients and methods: A total of 5,504 breast cancer patients from the Tianjin Breast Cancer Cases Cohort were included. Multivariable Cox regression was used to investigate the factors associated with overall survival (OS) and a nomogram was constructed based on these prognostic factors. The nomogram was internal and external validated and the performance was evaluated by area under the curve (AUC) and calibration curve. The partial score was also constructed and strati ﬁ ed them into low, moderate and high-risk subgroups for death according to the tripartite grouping method. Multivariate Cox regression analysis and the propensity score matching method were respectively used to test the association between adjuvant chemotherapy and OS in different risk subgroups. Results: Age, diameter, histological differentiation, lymph node metastasis, estrogen, and progesterone receptor were incorporated into the nomogram and validation results showed this nomogram was well-calibrated to predict the 3-year [AUC =74.1%; 95% con ﬁ dence interval (CI): 70.1 – 78.0%] and 5-year overall survival [AUC =72.3%; 95% CI: 69.6 – 75.1%]. Adjuvant chemotherapy was negatively associated with death in high risk subgroup [Hazard Ratio (HR) = 0.54; 95% CI: 0.37 – 0.77; P <0.001]. However, no signi ﬁ cant association were found in groups with low (HR=1.47; 95% CI: 0.52 – 4.19; P =0.47) and moderate risk (HR=0.78; 95% CI: 0.42 – 1.48; P =0.45). The 1:1 PSM generated 822 pairs of well-matched patients and Kaplan-Meier showed the high-risk patients could bene ﬁ t from chemotherapy, whereas low risk and moderate risk subjects did not appear to bene ﬁ t from chemotherapy. Conclusion: Not all of the breast cancer patients bene ﬁ t equally from chemotherapy. The nomogram could be used to evaluate the overall survival of breast cancer patients and predict the magnitude of bene ﬁ t and guide adjuvant chemotherapy for breast cancer patients after surgery.
Prognostic signi cance of translocator protein in the brain tissue following traumatic brain injury

Qing Bao Jiangsu University A liated Wujin Hospital: Changzhou Wujin People's Hospital Xuesong Yuan wujin hospital a liated with jiangsu university Xiaoxing Bian wujin hospital a liated with jiangsu university Wenfeng Wei wujin hospital a liated with jiangsu university Peng Jin wujin hospital a liated with jiangsu university Wenqing Jiang (  jiangwq@njmu.edu.cn ) Wujin Hospital A liated with Jiangsu University
Baiqian (2017) Lattice Boltzmann parallel simulation of microflow dynamics over structured surfaces. Advances in Engineering Software . ISSN 0965-9978

In the present work, a parallel lattice Boltzmann multiphase model was developed to investigate the effects of surface structures on wettabilities and flow dynamics in a microchannel. The theory of wetting transition was firstly discussed. Then three types including triangular, rectangle and hierarchical shaped microstructures were constructed on the surface to examine the effects on wettabilities and drag reduction. It was found that flow behaviour is strongly affected by the surface morphology of the channel. The results indicated that hierarchical structures on the surface could improve the hydrophobicity significantly. For rectangular structures, they can improve the hydrophobicity with the increase of height and distance ratio h/d of the structures, and the improvement will reach its optimal hydrophobicity when the value h/d is over a certain value of 0.6. Moreover, to accelerate computational speed, the Open Multi-Processing (OpenMP) was employed for the parallelization of the model. A maximum speedup of 2.95 times was obtained for 4 threads on a multi-core CPU platform.
The Competition Graphs of Interval Digraphs

Given a digraph D, we construct the competition graph of D, C(D), on the same vertex set as D with x and Y adjacent in C(D) if and only if there exists a vertex z such that x and y both have arcs to z in D. A digraph is an interval digraph if and only if two intervals S(x) and T(x) on the real line can be assigned to vertex x such that (x,y) \in A(D) if and only if S(x) \cap T(y) \neq 0. In this paper we show that the competition graph of an interval digraph is an interval graph and that every interval graph is in fact the competition graph of some digraph. These results are then related to previous work on competition graphs.
University of Birmingham Measurement of the B-0-B0 and B-0s-B0s production asymmetries in pp collisions at s = 7TeV

The B 0 – B 0 and B 0 s – B 0 s production asymmetries, A P ( B 0 ) and A P ( B 0 s ) , are measured by means of a time- dependent analysis of B 0 → J /ψ K ∗ 0 , B 0 → D − π + and B 0 s → D − s π + decays, using a data sample corresponding to an integrated luminosity of 1 . 0 fb − 1 , collected by LHCb in pp collisions at a centre- of-mass energy of 7 TeV. The measurements are performed as a function of transverse momentum and pseudorapidity of the B 0 and B 0 s mesons within the LHCb acceptance. The production asymmetries, integrated over p T and η in the range 4 < p T < 30 GeV / c and 2 . 5 < η < 4 . 5, are determined to be A P ( B 0 ) = ( − 0 . 35 ± 0 . 76 ± 0 . 28 ) % and A P ( B 0 s ) = ( 1 . 09 ± 2 . 61 ± 0 . 66 ) %, where the ﬁrst uncertainties are statistical and the second systematic.
Aberystwyth University Immunogenicity and protection against mycobacterium caprae challenge in goats vaccinated with BCG and revaccinated after one year

Vaccination has been proposed as a supplementary tool for the control of tuberculosis in livestock. The long-term immunogenicity elicited by bacillus Calmette–Guerin (BCG) and the efficacy of revaccination were investigated in thirty goat kids distributed into three groups: unvaccinated controls, BCG (vaccinated at week 0) and BCG-BCG (vaccinated at weeks 0 and 56). Sixty-four weeks after the first vaccination, all animals were challenged with Mycobacterium caprae and examined post-mortem (pathology and bacterial load) at week 73. Antigen-specific interferon-gamma (IFN-γ) release was measured throughout the experiment. At week 59, peripheral blood mononuclear cells were stained for CD4, CD45RO and IFN-γ to determine the presence of antigen-specific cells secreting IFN-γ. The BCG-BCG group showed reductions in rectal temperatures, M. caprae DNA load in pulmonary lymph nodes (LN), the volume of lesions in pulmonary LN, mineralization in lungs, and higher weight gains compared to unvaccinated controls. IFN-γ responses were undetectable from 32 weeks after primary vaccination until revaccination, when the BCG-BCG group showed detectable IFN-γ production and a greater percentage of antigen-specific CD4+CD45RO+IFNγ+ and CD4−CD45RO+IFNγ+ cells compared to the BCG and control groups, which may be an indicator of the mechanisms of protection. Thus, re-vaccination of goats with BCG appears to prolong protection against infection with M. caprae.
The Effect of Amino Acids on Sclerotium Formation of Rhizoctonia solani Kuhn (AG-1) I. Inhibition of Sclerotial Formation by Various Amino Acids

Inhibitive effect of some amino acids on sclerotial formation of Rhizoctonia solani (AG-1) was tested. Few or no sclerotia were formed on sulfur containing amino acids, histidine, leucine, isoleucine, tryptophan or tyrosine amended medium. Among these amino acids, leucine was not inhibitive and was merely unuseful for the formation. Inhibitive amino acids limited sclerotium formation and affected scarcely mycelial growth. Although the structural difference between cysteine and serine or homocysteine and homoserine was small, their effects on the formation were completely reverse. Sulfur or sulfhydryl bond could be an inhibitive principle. D-isomers of stimulative amino acids inhibited the formation. (Received October 18, 1979)
SYNTHESIS AND DEVELOPMENT OF 1,2,4-TRIAZOLYL-BENZOXAZOLE DERIVATIVES AS NOVEL COX-2 INHIBITORS

In the present research investigations we have synthesized a series of 2-(dialkylamino)-N-(5-(5-aryl-4-ureido-4H-1,2,4-triazol-3-yl)benzoxazol-2-yl)acetamides (Xa1-16). The newly synthesised derivatives were characterized by using the data of IR, 1 H NMR and Mass Spectral analysis. Thus synthesized and characterized targeted compounds were further screened for their in vitro COX-2 inhibition activity by using TMPD Assay method. The IC 50 values of Compounds Xa 13, 14, 15 and 16 were found to be more potent COX-2 inhibitors comparable to that of standard refecoxib, remaining compounds were shown mild to moderate COX-2 inhibitory activity. Thus, this class of compounds apart from the ease of synthesis and higher yield may serve as excellent candidates for selective COX-2 inhibition analysis.
255 Rapid Turnover of Effector–Memory CD4 (cid:2) T Cells in Healthy

UK Abstract Memory T cells can be divided into central–memory (T CM ) and effector–memory (T EM ) cells, which differ in their functional properties. Although both subpopulations can persist long term, it is not known whether they are maintained by similar mechanisms. We used in vivo labeling with deuterated glucose to measure the turnover of CD4 (cid:2) T cells in healthy humans. The CD45R0 (cid:2) CCR7 (cid:3) T EM subpopulation was shown to have a rapid proliferation rate of 4.7% per day compared with 1.5% per day for CD45R0 (cid:2) CCR7 (cid:2) T CM cells; these values are equivalent to average intermitotic (doubling) times of 15 and 48 d, respectively. In contrast, the CD45RA (cid:2) CCR7 (cid:2) naive CD4 (cid:2) T cell population was found to be much longer lived, being labeled at a rate of only 0.2% per day (corresponding to an intermitotic time of approximately 1 yr). These data indicate that human CD4 (cid:2) T EM cells constitute a short-lived cell population that requires continuous replenishment in
Research on factors influencing the provincial technical inefficiency of forest parks under multi-output targets in China

: Forest parks are designed to provide economic, social and ecological effects. Based on provincial statistical data related to forest parks in mainland China and collection of each year from 2004 to 2015, the present study employed stochastic frontier analysis to demonstrate the provincial technical efficiency and inefficiency of the multiple output targets established for these forest parks, including economic, social, and ecological products. By referring to the supply- demand theory, a Tobit model was used to measure and analyze the effects of supply factors and demand factors on the provincial technical inefficiency of these forest parks. This study showed that the mean of provincial technical efficiency of China ’ s forest parks was only 0. 3684 from 2004 to 2015, leaving plenty of room for promotion. The average of total inefficiency was as high as 0.6316, and the mean of technical inefficiency was also as high as 0. 5144. The efficiency values of forest parks for the main forest regions in China listed in descending order were: Southwest Forest Region, Southern Forest Region, North Forest Region, Northeast Forest Region and Northwest Forest Region. For influencing factors of demand, a nonlinear and U-shaped relationship was observed between GDP per capita and provincial technical inefficiency of these forest parks. Meanwhile, the population density and urbanization rate did exhibit a positive influence on the provincial technical inefficiency of these forest parks. For influencing factors of supply, high- level tourism resource density, high- grade highway density, forest coverage, and investment intensity illustrated a negative influence on the provincial technical inefficiency of these forest parks to varying degrees.
Effect of (cid:1) 2-Adrenergic Receptor Stimulation on Interleukin-18-Induced Intercellular Adhesion Molecule-1 Expression and Cytokine Production

(cid:1) -Adrenergic receptor (AR) agonists have been demonstrated to modulate the production of inflammatory mediators. Recent studies implied that (cid:1) 2-AR agonists might be useful for chronic inflammatory diseases caused by interleukin (IL)-18. In the present study, we found that norepinephrine, epinephrine, or isoproterenol down-regulated IL-18 (100 ng/ml)-induced inter- cellular adhesion molecule (ICAM)-1 expression on monocytes in a dose-dependent manner (10 (cid:1) 8 –10 (cid:1) 4 M), but did not effect B7.1 and B7.2 expression after 24-h incubation. The modula- tory effect of these catecholamines on ICAM-1 expression was antagonized by (cid:1) 2-AR antagonist, but not by (cid:2) 1-, (cid:2) 2-, or (cid:1) 1-AR antagonist. (cid:1) 2-AR-selective agonists salbutanol and terbutaline down-regulated IL-18-induced ICAM-1 expression on monocytes, but (cid:2) 1-, (cid:2) 2-, or (cid:1) 1-AR agonist had no effect. In the same manner, salbutanol and terbutaline as well as norepi- nephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor- (cid:2) or interferon- (cid:3) through the stimulation of (cid:1) 2-AR. Together with the previous finding that ICAM-1/lymphocyte func- tion-associated antigen-1 interaction plays a crucial role in the IL-18-initiated cytokine network, the present study strongly suggested that the stimulation of (cid:1) 2-AR inhibited the IL-18-activated cytokine cascade through the inhibitory effect on ICAM-1 expression, contributing to finding a new method for clinical treatment.
Binding of High Affinity Heparin to Antithrombin I 11

The kinetics of high affinity heparin binding to human antithrombin III has been studied by stopped flow fluorimetry, using the 40% antithrombin fluorescence enhancement resulting from this interaction. At p 0.15, pH 7.4, and 25 “C, the observed pseudo-first order rate constant varies hyperbolically with heparin concentration with a limiting rate constant of 440 & 90 s-’, demonstrating that heparin binding is a two-step process involving a conformational change in antithrombin III. An identical dependence is produced when antithrombin is varied, consistent with a symmetrical mechanism in which heparin binding induces a conformational change in antithrombin rather than perturbing an equilibrium between two conformational states of the protein. The rate constant for dissociation of the antithrombin-heparin complex is 1.1-1.5 s-l at p 0.15, as determined from the ordinate intercept at low heparin concentrations or by dissociation of the antithrombin-heparin complex with iodide. Observation of single pseudo-first order binding rates over a 400-fold heparin concentration range with no detectable lags is compatible with the initial binding step being in rapid equilibrium with a KD of 4.3 f 1.3 X lo-’ M at p 0.15. Variation in ionic strength primarily affects the KO for the initial binding step with little effect on the conformational change rate constants, implying that binding involves ionic interactions. Calculation of the overall dissociation equilibrium constant from these rate parameters agrees with the directly determined value of 7.2 f 1.9 X lo-’ M at p 0.15. A major function of the conformational change is, thus, to increase the affinity of heparin for antithrombin III greater than 300-fold. The implications of these findings for the mechanism of the heparin-catalyzed inhibition of coagulation proteases by antithrombin 111 are discussed.
SIGN-CHANGING SOLUTIONS FOR p -LAPLACIAN EQUATIONS WITH JUMPING NONLINEARITY AND THE FUˇCIK SPECTRUM

We study the existence of sign-changing solutions for the p Laplacian equation where λ is a positive parameter and the nonlinear term f has jumping nonlinearity at inﬁnity and is superlinear at zero. The Fuˇcik spectrum plays an important role in the proof. We give suﬃcient conditions for the existence of nontrivial Fuˇcik spectrum.
Systematic Reviews and Meta- and Pooled Analyses Parental, In Utero, and Early-Life Exposure to Benzene and the Risk of Childhood Leukemia: A Meta-Analysis

Benzene is an established cause of adult leukemia, but whether it is associated with childhood leukemia remains unclear. We conducted a meta-analysis in which we reviewed the epidemiologic literature on this topic and explored causal inference, bias, and heterogeneity. The exposure metrics that we evaluated included occupational and household use of benzenes and solvents, traffic density, and traffic-related air pollution. For studies of occupational and household product exposure published from 1987 to 2014, the summary relative risk for childhood leukemia was 1.96 (95% confidence interval (CI): 1.53, 2.52; n = 20). In these studies, the summary relative risk was higher for acute myeloid leukemia (summary relative risk (sRR) = 2.34, 95% CI: 1.72, 3.18; n = 6) than for acute lymphoblastic leukemia (sRR = 1.57; 95% CI: 1.21, 2.05; n = 14). The summary relative risk was higher for maternal versus paternal exposure, in studies that assessed benzene versus all solvents, and in studies of gestational exposure. In studies of traffic density or traffic-related air pollution published from 1999 to 2014, the summary relative risk was 1.48 (95% CI: 1.10, 1.99; n = 12); it was higher for acute myeloid leukemia (sRR = 2.07; 95% CI: 1.34, 3.20) than for acute lymphoblastic leukemia (sRR = 1.49; 95% CI: 1.07, 2.08) and in studies that involved detailed models of traffic pollution (sRR = 1.70; 95% CI: 1.16, 2.49). Overall, we identified evidence of associations between childhood leukemia and several different potential metrics of benzene exposure.
Examination of Best-time Estimation for Each Tourist Spots by Interlinking using Geotagged Tweets

—Numerous studies have been conducted to analyze social media data in real time and to extract events occurring in the real world. A benefit of analysis using data with position information is that it can accurately extract an event from a target area to be analyzed. However, because data with position information are scarce among all social media data, the amount to analyze is insufficient for almost all areas: we cannot fully extract most events. Therefore, efficient analytical methods must be devised for accurate extraction of events with position information, even in areas with few data. For this study, we estimate the time of biological season observation in areas and sightseeing spots with interlinkage of tweet location information. Herein, we explain the analysis results obtained using information from interpolation and analysis of cherry blossoms in Japan in 2016.
Mathematical Modeling and Control of COVID-19 Using Super Twisting Sliding Mode and Nonlinear Techniques

Since the outbreak of the COVID-19 epidemic, several control strategies have been proposed. The rapid spread of COVID-19 globally, allied with the fact that COVID-19 is a serious threat to people's health and life, motivated many researchers around the world to investigate new methods and techniques to control its spread and offer treatment. Currently, the most effective approach to containing SARS-CoV-2 (COVID-19) and minimizing its impact on education and the economy remains a vaccination control strategy, however. In this paper, a modified version of the susceptible, exposed, infectious, and recovered (SEIR) model using vaccination control with a novel construct of active disturbance rejection control (ADRC) is thus used to generate a proper vaccination control scheme by rejecting those disturbances that might possibly affect the system. For the COVID-19 system, which has a unit relative degree, a new structure for the ADRC has been introduced by embedding the tracking differentiator (TD) in the control unit to obtain an error signal and its derivative. Two further novel nonlinear controllers, the nonlinear PID and a super twisting sliding mode (STC-SM) were also used with the TD to develop a new version of the nonlinear state error feedback (NLSEF), while a new nonlinear extended state observer (NLESO) was introduced to estimate the system state and total disturbance. The final simulation results show that the proposed methods achieve excellent performance compared to conventional active disturbance rejection controls.
ANTIBACTERIAL ACTIVITIES OF ESSENTIAL OILS ISOLATED FROM TWO SPECIES CUPRESSUS ARIZONICA GREENE AND CUPRESSUS SEMPERVIRENS L. (VAR. HORIZONTALIS AND PYRAMIDALIS )

Cupressus sempervirens L. and Cupressus arizonica Greene are two cone-bearing coniferous woody plant species of the Cupressaceae family found in Lebanon. The essential oils of the introduced species Cupressus arizonica Greene and those of each of the two native varieties of the species C. sempervirens L. (var. pyramidalis and horizontalis), both collected in Lebanon, were isolated from their cones by hydrodistillation. By using the agar disc diffusion method, we aim at studying the antibacterial activity of each of these oils against two bacterial strains, namely the Gram-positive Staphylococcus epidermidis and the Gram-negative Escherichia coli . A significant antibacterial activity was obtained by all plant extracts tested. However, this study revealed that both varieties of the species C. sempervirens exhibited an inhibitory activity slightly greater than that of the C. arizonica against the Gram-positive bacteria, whereas C. arizonica showed a slightly greater inhibitory activity against the Gram-negative bacteria used in this study.
Key questions on the epigenetics of herpes simplex virus latency

The human pathogen, herpes simplex virus (HSV), has established a successful mechanism to persist long term in its host by maintaining a latent infection in neurons. Latent infection is defined as long-term carriage of the viral genome but lack of detectible infectious virus and the ability to reactivate following a specific stimulus. During latency, the HSV genome exists as a nuclear, unintegrated episome. Although multiple factors regulate entry into latent infection, the epigenetic structure of the latent HSV genome in neurons differs from the configuration of the viral genome during lytic infection of nonneuronal cells and therefore appears to play a central role in regulating viral gene transcription. Since the initial discoveries of chromatiniza-tion of the HSV genome during latency, multiple new developments have been made in how the viral genome could be epigenetically silenced in a way that promotes long-term persistence while maintaining the ability to reactivate. Here, we highlight recent developments and incor-porate new questions that will ultimately help understand how HSV latency occurs in neurons and how the epigenetic structure of the viral genome may ultimately impact clinical HSV-asso-ciated disease. located on the of