Miracle-dz/UniFAR-FTUs huggingface dataset:
VIRTUAL TOOLS ECOSYSTEM FOR PERIURBAN GREEN AREAS MONITORING AND PROMOTION: OUTCOMES AND OUTLOOKS OF THE INSUBRIPARKS PROJECT

Abstract. Green areas such as natural and periurban parks provide support to biodiversity and landscape preservation while boosting local economic growth in their hosting territories, thanks to the establishment of eco-tourism activities. Smart management and promotion actions are vital for the sustainable exploitation of such benefits for citizens and visitors. These tasks may be hindered by a lack of economic resources and digital skills of public authorities but also by fragmented local political contexts to which these areas may be subjected. The parks in the Insubria region (between Southern Switzerland and Northern Italy) represent a relevant example of the above. The INSUBRIPARKS project aims at the harmonisation of management and promotion practices for the Insubria parks. The project activities encompass multiple actions, from the establishment of unified territorial marketing strategies to the development of supporting IT tools. Accordingly, this paper provides an overview of the IT tools ecosystem which was designed and developed within the project and an outlook on its role in empowering smart monitoring and promotion for these parks. Tools include a Web portal (enriched with Web mapping components) for a unified presentation of the tourism offers, an analysis framework for social media data exploitation in park visitors’ fluxes assessment, and a mobile tool for users’ engagement in the park areas monitoring. Alongside technical descriptions, lessons learned and residual challenges for the operative adoption of the tools are discussed as to their future improvements.
Low Dehydroepiandrosterone (DHEA) Level Is Associated with Poor Immunologic Response among People Living with HIV/AIDS

Dehydroepiandrosterone (DHEA) is an adrenal steroid converted to potent androgens. This study aimed to discover the association between serum DHEA levels and immunologic response in people with HIV/AIDS (PLWHA). We enrolled patients aged ≥ 18 years who were treated with combination antiretroviral therapy (cART). We measured CD4+ and CD8+ T-cell counts, HIV-RNA titres, and serum DHEA levels. We assigned each patient to a good- or poor-responder group depending on their CD4+ T-cell counts at study enrolment. Participants with CD4+ T-cell counts > 200/µL were assigned to the good-responder group, whilst those with CD4+ T-cell counts < 200/µL were assigned to the poor-responder group. The participants were followed up for 2 years. The poor-responder group showed lower CD4+ T-cell counts and higher HIV PCR titres at their initial HIV diagnosis and in their 2-year follow-up data. Serum DHEA level was lower in the poor-responder group. Multivariable logistic analysis showed that BMI, initial CD4+ T-cell counts, and serum DHEA level were clinical factors associated with poor immunologic responsiveness to cART in PLWHA. Therefore, DHEA may be used as an indicator of the immunological recovery of PLWHA.
Diastereoselective Synthesis of Highly Functionalized Proline Derivatives

An efficient way to access highly functionalized proline derivatives was developed based on a Cu(I)-catalyzed reaction between CF3-substituted allenynes and tosylazide, which involved a cascade of [3 + 2]-cycloaddition/ketenimine and a rearrangement/Alder-ene cyclization to afford the new proline framework with a high diastereoselectivity.
Non-parametric competing risks with multivariate frailty models

This research focuses on two theories: (i) competing risks and (ii) random effect (frailty) models. The theory of competing risks provides a structure for inference in problems where cases are subject to several types of failure. Random effects in competing risk models consist of two underlying distributions: the conditional distribution of the response variables, given the random effect, depending on the explanatory variables each with a failure type specific random effect; and the distribution of the random effect. In this situation, the distribution of interest is the unconditional distribution of the response variable, which may or may not have a tractable form. The parametric competing risk model, in which it is assumed that the failure times are coming from a known distribution, is widely used such as Weibull, Gamma and other distributions. The Gamma distribution has been widely used as a frailty distribution, perhaps due to its simplicity since it has a closed form expression of the unconditional hazard function. However, it is unrealistic to believe that a few parametric models are suitable for all types of failure time. This research focuses on a distribution free of the multivariate frailty models. Another approach used to overcome this problem is using finite mixture of parametric frailty especially those who have a closed form of unconditional survival function. In addition, the advantages and disadvantages of a parametric competing risk models with multivariate parametric and/or non-parametric frailty (correlated random effects) are investigated. In this research, four main models are proposed: first, an application of a new computation and analysis of a multivariate frailty with competing risk model using Cholesky decomposition of the Lognormal frailty. Second, a correlated Inverse Gaussian frailty in the presence of competing risks model. Third, a non-parametric multivariate frailty with parametric competing risk model is proposed. Finally, a simulation study of finite mixture of Inverse Gaussian frailty showed the ability of this model to fit different frailty distribution. One main issue in multivariate analysis is the time it needs to fit the model. The proposed non-parametric model showed a significant time decrease in estimating the model parameters (about 80% less time compared the Log-Normal frailty with nested loops). A real data of recurrence of breast cancer is used as the applications of these models.
Single Cell in a Gravity Field

The exploration of deep space or other bodies of the solar system, associated with a long stay in microgravity or altered gravity, requires the development of fundamentally new methods of protecting the human body. Most of the negative changes in micro- or hypergravity occur at the cellular level; however, the mechanism of reception of the altered gravity and transduction of this signal, leading to the formation of an adaptive pattern of the cell, is still poorly understood. At the same time, most of the negative changes that occur in early embryos when the force of gravity changes almost disappear by the time the new organism is born. This review is devoted to the responses of early embryos and stem cells, as well as terminally differentiated germ cells, to changes in gravity. An attempt was made to generalize the data presented in the literature and propose a possible unified mechanism for the reception by a single cell of an increase and decrease in gravity based on various deformations of the cortical cytoskeleton.
Jet substructure in ATLAS

Measurements are presented of the jet invariant mass and substructure in proton-proton collisions at sqrt{s} = 7 TeV with the ATLAS detector using an integrated luminosity of 37 pb-1. These results exercise the tools for distinguishing the signatures of new boosted massive particles in the hadronic final state. Two "fat" jet algorithms are used, along with the filtering jet grooming technique that was pioneered in ATLAS. New jet substructure observables are compared for the first time to data at the LHC. Finally, a sample of candidate boosted top quark events collected in the 2010 data is analyzed in detail for the jet substructure properties of hadronic "top-jets" in the final state. These measurements demonstrate not only our excellent understanding of QCD in a new energy regime but open the path to using complex jet substructure observables in the search for new physics.
Updated Perspectives on the Role of Biomechanics in COPD: Considerations for the Clinician

Abstract Patients with chronic obstructive pulmonary disease (COPD) demonstrate extra-pulmonary functional decline such as an increased prevalence of falls. Biomechanics offers insight into functional decline by examining mechanics of abnormal movement patterns. This review discusses biomechanics of functional outcomes, muscle mechanics, and breathing mechanics in patients with COPD as well as future directions and clinical perspectives. Patients with COPD demonstrate changes in their postural sway during quiet standing compared to controls, and these deficits are exacerbated when sensory information (eg, eyes closed) is manipulated. If standing balance is disrupted with a perturbation, patients with COPD are slower to return to baseline and their muscle activity is differential from controls. When walking, patients with COPD appear to adopt a gait pattern that may increase stability (eg, shorter and wider steps, decreased gait speed) in addition to altered gait variability. Biomechanical muscle mechanics (ie, tension, extensibility, elasticity, and irritability) alterations with COPD are not well documented, with relatively few articles investigating these properties. On the other hand, dyssynchronous motion of the abdomen and rib cage while breathing is well documented in patients with COPD. Newer biomechanical technologies have allowed for estimation of regional, compartmental, lung volumes during activity such as exercise, as well as respiratory muscle activation during breathing. Future directions of biomechanical analyses in COPD are trending toward wearable sensors, big data, and cloud computing. Each of these offers unique opportunities as well as challenges. Advanced analytics of sensor data can offer insight into the health of a system by quantifying complexity or fluctuations in patterns of movement, as healthy systems demonstrate flexibility and are thus adaptable to changing conditions. Biomechanics may offer clinical utility in prediction of 30-day readmissions, identifying disease severity, and patient monitoring. Biomechanics is complementary to other assessments, capturing what patients do, as well as their capability.
FATORES RELACIONADOS A CANDIDÍASE VULVOVAGINAL NAS MULHERES EM SEU CICLO VITAL: UMA REVISÃO INTEGRATIVA

A candidíase vulvovaginal (CVV) é ocasionada pelo crescimento anormal de fungos leveduriformes na mucosa do trato genital feminino como consequência de uma série de alterações endócrinas e imunológicas e uso indiscriminado e prolongado de antibióticos. Nesta perspectiva, o presente trabalho teve como objetivo realizar uma busca nas bases de dados a fim de encontrar evidências cientificas que apontem os fatores relacionados a candidíase vulvovaginal nas mulheres em seu ciclo vital. A busca foi realizada nas bases de dados Literatura Latino- Americana e do Caribe em Ciências da Saúde (lilacs); Scientific Electronic Library Online (SciELO); Medical Literature Analysis and Retrieval System Online (Medline/Pubmed) e na Base de Dados de Enfermagem (BDENF), utilizando-se os respectivos Decs/MeSh, bem como os conectores booleanos AND e OR. A partir da busca primária, foram encontradas 403 produções científicas e, após análise dos critérios de exclusão referentes ao ano de publicação e temática, obteve-se 12 artigos elegíveis para esta revisão integrativa. As pesquisas selecionadas envolveram mulheres em idade fértil e gestantes. A maior parte das publicações foram realizadas em 2019 e 2020. Nota-se que o desequilíbrio hormonal foi o fator de risco associado mais prevalente. Dentre os agentes da microbiota identificados a Candida albanis foi o microrganismo mais prevalente em todos os estudos. O corrimento vaginal foi o sintoma mais frequente em todos os estudos. Além disso, nove pesquisas relataram irritação da vulva e vagina, eritema vulvar e prurido vaginal no período fértil, dentre outros sintomas.
Experimental and Numerical Study on Mixed Lubrication Performance of Journal Bearing Considering Misalignment and Thermal Effect

The shaft misalignment under mixed lubrication is an important factor affecting the running performance of the bearing, which can occur under heavy load and unsatisfactory assembly. This paper presents a misaligned journal mixed lubrication model coupling for the asperity contact effect, elastic deformation, viscosity–temperature, and viscosity–pressure effect. The finite difference method was employed to calculate the model, and an experimental apparatus designed in this paper was used to test the friction and temperature characteristics of the specimens. The results show that the pressure field, film thickness, and elastic deformation of the bearing conformed to asymmetric distribution along the axial direction under misalignment conditions and there was a notable end side effect. In addition, the frictional force and side leakage flow were evidently enhanced with the increase in the inclination angle in a certain range. The experimental results showed that there was a visible wear phenomenon on the end sides of the bush and shaft. The research results are beneficial for understanding the mixed lubrication mechanism of misaligned journal bearing.
The Beneficial Effect of Cinnamon and Red Capsicum Intake on Postprandial Changes in Plasma Metabolites Evoked by a High-Carbohydrate Meal in Men with Overweight/Obesity

The relationship of high-carbohydrate (HC) meal intake to metabolic syndrome is still not fully explained. Metabolomics has the potential to indicate metabolic pathways altered by HC meals, which may improve our knowledge regarding the mechanisms by which HC meals may contribute to metabolic syndrome development. The fasting and postprandial metabolic response to HC or normo-carbohydrate (NC) meals with/without cinnamon + capsicum intake was evaluated using untargeted metabolomics and compared between normal-weight (NW) and overweight/obese (OW/OB) healthy men. Healthy male participants (age-matched) were divided into two groups (12 subjects per group). One was composed of men with normal weight (NW) and the other of men with overweight/obesity (OW/OB). On separate visits (with 2–3 week intervals), the participants received standardized HC or NC meals (89% or 45% carbohydrates, respectively). Fasting (0 min) and postprandial (30, 60, 120, 180 min) blood were collected for untargeted plasma metabolomics. Based on each metabolic feature’s intensity change in time, the area under the curve (AUC) was calculated. Obtained AUCs were analyzed using multivariate statistics. Several metabolic pathways were found dysregulated after an HC meal in people from the OW/OB group but not the NW group. The consumption of HC meals by people with overweight/obesity led to a substantial increase in AUC, mainly for metabolites belonging to phospholipids and fatty acid amides. The opposite was observed for selected sphingolipids. The intake of cinnamon and capsicum normalized the concentration of selected altered metabolites induced by the intake of HC meals. A HC meal may induce an unfavourable postprandial metabolic response in individuals with overweight/obesity, and such persons should avoid HC meals.
Bronchodilator Responsiveness Defined by the 2005 and 2021 ERS/ATS Criteria in Patients with Asthma as Well as Chronic Obstructive Pulmonary Disease

Background In the 2021 ERS/ATS interpretive strategies for routine lung function tests, a positive bronchodilator response (BDR) was updated as a change of >10% relative to the predicted value in forced expiratory volume in 1 second (FEV1) or forced vital capacity (FVC). We aimed to explore the differences between the 2005 and 2021 ERS/ATS criteria applied to patients with asthma as well as chronic obstructive pulmonary disease (COPD). Methods BDR test data about asthma patients aged 6–80 years and COPD patients aged 18–80 years were derived from the National Respiratory Medicine Center, First Affiliated Hospital of Guangzhou Medical University, from January 2017 to March 2022. BDR results defined by the 2005 and 2021 ERS/ATS criteria were named 2005-BDR and 2021-BDR, respectively. We compared differences between 2005-BDR and 2021-BDR and analyzed the trend in the proportion of positive BDR (BDR+) with the level of airflow obstruction. Results A total of 4457 patients with asthma and 7764 patients with COPD were included in the analysis. The percentages of 2005-BDR+ and 2021-BDR+ were 63.32% and 52.84% for asthma, 30.92% and 22.94% for COPD, respectively. Of patients with 2005-BDR+, 81.86% for asthma and 70.18% for COPD showed 2021-BDR+ results, and these patients had higher FEV1%pred, FVC%pred (all P<0.05). Whichever BDR criterion was adopted, the proportion of BDR+ had an upward linear trend with the increased degree of airflow obstruction in COPD, but exhibited an approximate inverted U-shaped curve in asthma. In COPD, the proportion of BDRFEV1 was negatively associated with the degree of airflow obstruction, while BDRFVC was positively associated (all P<0.05). Conclusion Compared with 2005-BDR+, the proportion of 2021-BDR+ reduced markedly in patients with asthma and COPD, but their trends with the degree of airflow obstruction did not change. Patients with consistent BDR+ had higher initial FEV1%pred and FVC%pred.
The Moderating Role of Maternal Education and Employment on Child Health in Pakistan

Background: Pakistan has challenges in fulfilling its universal responsibilities of providing better health facilities to everyone. The Sustainable Development Goals (SDGs) aim to reduce maternal and infant mortality rates. Despite declines in mother and child death, the total mortality ratio has marginally increased. However, neonatal death has not decreased significantly. Family planning is important for controlling population growth and improving child as well as maternal health. Pakistan’s government has unceasingly tried to enhance the provision of contraceptive facilities, but still, an unmet need for family planning (UMNFP) exists in our country. Women are said to have UMNFP if they want to limit or space childbearing, but they are not using contraception methods for any reason. The study aimed to explore the effect of the UMNFP and to investigate the moderating role of a mother’s education and employment status on a child’s health. Methods: We analyzed the data of 2,244 women in this study. To investigate the study objectives, we utilized the secondary dataset of the Pakistan Demographic and Health Survey (PDHS) 2017–18 (publicly available on the website of the National Institute of Population Studies) and applied binary logistic regression using SPSS 24. Results: Results suggest a positive effect of a woman’s age (25 to 39 years), maternal education (higher), father’s education (higher), family’s wealth status (richest), mass media exposure, and adequate birth spacing (at least for 33 months) on a child’s health. On the other hand, there is an indirect association between maternal employment, unmet need for family planning, and a child’s health. The moderating role of maternal education and employment on the relationship between household wealth status and a child’s health is positive. Conclusions: We conclude that the strong predictors of child health are UMNFP, maternal education, and employment. The link between the met need for family planning and the child’s health is positive. The moderating effect of maternal education and household wealth status on a child’s health is progressive. Similarly, the interaction effect of a mother’s employment and household wealth status on a child’s health is positive. Finally, we concluded that the link between the health of the child and household wealth status is much more diverse and positive when the mother is highly educated and currently employed.
The overset grid method, applied to the solution of the incompressible Navier-Stokes equations in two and three spatial dimensions

The generation of structured grids around complex geometries is generally a difficult task. Thistask is typically a major bottleneck in the overall solution procedure; however, the overset gridmethod can be used to relieve much of this burden. An overset grid consists of a set of simplecomponent grids, which can overlap arbitrarily (provided there is sufficient overlap to interpolatefrom). The union of all simple grids should then delineate the global domain. This allows complex domains to meshed using a series of simple meshes. Interpolation boundary conditions are enforced at internal boundaries to ensure a continuous solution. Standard tri-linear interpolation is typically used for this purpose, although there are alternative methods that attempt to enforce global conservation.A new CFD code has been developed that incorporates the overset grid method in three spatialdimensions. This code uses the steady state, finite volume discretisation method. SIMPLE pressure velocity coupling has been used on a colocated grid with Rhie-Chow interpolation for face velocities. Different interpolation methods have been compared for the information transfer at internal boundaries from one grid to the next. It has been shown that for a variety of test cases, continuous and accurate solutions are obtained from one grid to another, which are comparable to those of the single-block or block-structured solutions, or to experimental data (where available). A new hole cutting algorithm and bulk correction outlet condition are presented. Improvements to existing digital tree data structures are also described.Lid driven cavity flow, the flow around rotating cylinders, and flow impingement onto a concavesurface are considered in order to demonstrate the method. The flow over a backward facing step, over a multi-element airfoil, through a bifurcating artery and over a wing-body junction are then considered (with experimental comparison). This demonstrates the range of applicability of the method. In all cases, the overset method offers significant advantages over block-structured solutions that are available in the literature. It is shown that greater numerical efficiency is generally achievable via the use of an overset simulation: Since the gridding is flexible, high aspect ratio cells need not propagate into the domain (as is often the case for a block-structured arrangement). Also, much of the domain away from localised regions of geometrical complexity can be meshed with efficientCartesian grids.
Effects of Circuit Training on Patients with Knee Osteoarthritis: A Systematic Review and Meta-Analysis

The most prevalent joint disease is osteoarthritis (OA), which affects an estimated 240 million individuals worldwide. Knee osteoarthritis (KOA) is one of the top 10 causes of disability worldwide. The aim of this study is to systematically evaluate the effect of circuit training (CT) on patients with KOA. We searched through PubMed, Scopus, ScienceDirect, Cochrane, and Google Scholar up to 12 February 2022. We used random-effects statistical analysis for continuous variables and reported the results as a standardized mean difference (SMD) with 95 percent confidence intervals (CI). Seven trials involving 346 patients were included. A significant improvement in the intervention group was observed for the parameter, pain level (SMD −0.96, 95% CI −1.77 to −0.14; p = 0.02; seven trials, 346 participants; high quality evidence), while no significant improvement was found in physical function (SMD 0.03, 95% CI −0.44–0.50; p = 0.89; five trials, 294 participants; high-quality evidence), quality of life (SMD −0.25, 95% CI −1.18–0.68; p = 0.60; three trials, 205 participants; high-quality evidence), the activity of daily living (SMD 0.81, 95% CI −0.85–2.48; p = 0.34; three trials, 223 participants; high-quality evidence), and knee stiffness (SMD −0.65, 95% CI −1.96–0.66; p = 0.33; two trials, 71 participants; high-quality evidence). The findings in this meta-analysis suggest that CT could effectively complement the conventional treatment of KOA, particularly in alleviating pain. However, comprehensive data on the guidelines for the CT approach would be needed to adequately examine the effects of CT on quality of life and biochemical markers in patients with KOA.