Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of the glmU Gene Encoding N-Acetylglucosamine-1-Phosphate Uridyltransferase in Escherichia coli

The physiological properties of the EcoURF-1 open reading frame, which precedes the gbnS gene at 84 min on the Escherichia coli chromosome (J. E. Walker, N. J. Gay, M. Saraste, and A. N. Eberle, Biochem. J. 224:799-815, 1984), were investigated. A thermosensitive conditional mutant in which the synthesis of the gene product was impaired at 43°C was constructed. The inactivation of the gene in exponentially growing cells rapidly inhibited peptidoglycan synthesis. As a result, various alterations of cell shape were observed, and cell lysis finally occurred when the peptidoglycan content was 37% lower than that of normally growing cells. Analysis of the pools of peptidoglycan precursors revealed a large accumulation of N-acetylglucosamine-l-phosphate and the concomitant depletion of the pools of the seven peptidoglycan nucleotide precursors located downstream in the pathway, a result indicating that the mutational block was in the step leading from N-acetylglucosamine-l-phosphate and UTP to the formation of UDP-N-acetylglucosamine. In vitro assays showed that the overexpression of this gene in E. col cells, directed by appropriate plasmids, led to a high overproduction (from 25- to 410-fold) of N-acetylglucosamine-l-phosphate
Euclid preparation

Galaxy cluster counts in bins of mass and redshift have been shown to be a competitive probe to test cosmological models. This method requires an efficient blind detection of clusters from surveys with a well-known selection function and robust mass estimates, which is particularly challenging at high redshift. The Euclid wide survey will cover 15 000 deg2 of the sky, avoiding contamination by light from our Galaxy and our solar system in the optical and near-infrared bands, down to magnitude 24 in the H-band. The resulting data will make it possible to detect a large number of galaxy clusters spanning a wide-range of masses up to redshift ∼2 and possibly higher. This paper presents the final results of the Euclid Cluster Finder Challenge (CFC), fourth in a series of similar challenges. The objective of these challenges was to select the cluster detection algorithms that best meet the requirements of the Euclid mission. The final CFC included six independent detection algorithms, based on different techniques, such as photometric redshift tomography, optimal filtering, hierarchical approach, wavelet and friend-of-friends algorithms. These algorithms were blindly applied to a mock galaxy catalog with representative Euclid-like properties. The relative performance of the algorithms was assessed by matching the resulting detections to known clusters in the simulations down to masses of M200 ∼ 1013.25 M⊙. Several matching procedures were tested, thus making it possible to estimate the associated systematic effects on completeness to < 3%. All the tested algorithms are very competitive in terms of performance, with three of them reaching > 80% completeness for a mean purity of 80% down to masses of 1014 M⊙ and up to redshift z = 2. Based on these results, two algorithms were selected to be implemented in the Euclid pipeline, the Adaptive Matched Identifier of Clustered Objects (AMICO) code, based on matched filtering, and the PZWav code, based on an adaptive wavelet approach.
No evidence of sexual dimorphism in the tails of the swallowtail butterflies Papilio machaon gorganus and

The European swallowtail butterfly ( Papilio machaon ) is so named, because of the long and narrow prominences extending from the trailing edge of their hindwings and, although not a true tail, they are referred to as such. Despite being a defining feature, an unequivocal function for the tails is yet to be determined, with predator avoidance (diverting an attack from the rest of the body), and enhancement of aero dynamic performance suggested. The swallowtail, however, is sexually size dimorphic with females larger than males, but whether the tail is also sexually dimorphic is un -known. Here, museum specimens were used to determine whether sexual selection has played a role in the evolution of the swallowtail butterfly tails in a similar way to that seen in the tail streamers of the barn swallow ( Hirundo rustica ), where the males have longer streamers than those of the females. Previously identified sexual dimor phism in swallowtail butterfly size was replicated, but no evidence for dimorphism in tail length was found. If evolved to mimic antennae and a head to divert a predatory attack, and if
What Strengths and Difficulties Do Mothers with Gynecological Cancer and Healthy Fathers Report in Their Children?

1 Jahr nach T2) einen Fragebogen zu Stärken und Schwächen des Kindes sowie zur eigenen Belastung durch die Erkrankung, dem Ausmaß sozialer Unterstützung sowie der partnerschaftlichen Bewältigung der Erkrankung. Aufgrund der ge-ringen Fallzahlen zu T3 und T4 konzentriert sich die gegen-wärtige Untersuchung auf die ersten beiden Messzeit-punkte. Ergebnisse: Zu jedem Messzeitpunkt schätzten beide Eltern die Kinder als überwiegend psychisch unauf-fällig und prosozial ein. Diejenigen Mütter, die zu T1 stärker durch die Krebserkrankung belastet waren, berichteten zu T2 auch mehr psychische Auffälligkeiten bei ihren Kindern. Dieser wurde vollständig über das Ausmaß der partnerschaftlichen Bewältigung der Erkrankung zu T1 mediiert. Diskussion: Sollten diese Er-gebnisse repliziert werden, könnten sie hin weisen, dass indizierte Präventionsmaßnahmen bei mit das einer manifesten psychischen bei betroffenen und Jugendlichen unter verhindern. Eine Möglichkeit, die Indikation für eine solche Maßnahme zu stellen, kann in der Einschätzung der individuellen Belastung durch die Krebserkrankung und des Ausmaßes an Unterstützung innerhalb der Partnerschaft illness (DCI) and the scales for social support should be used as predictors of the parents’ individual distress measurements at T1 (depressive mood, progressive anxiety, distress because of illness).
Long-Term Effects of Ramipril on Cardiovascular Events and on Diabetes Results of the HOPE Study Extension Preventive Cardiology

Background —We have previously demonstrated that ramipril reduces vascular events and new diagnoses of diabetes when given for a 4.5-year period. However, it is not known whether the benefits are observed in subgroups of patients at varying risk or on other proven therapies and whether the benefits are sustained beyond the current trial. The 2 aims of this investigation were to assess whether the benefits observed during the HOPE trial were (1) maintained after trial cessation during an additional 2.6 years of follow-up and (2) observed in subgroups based on risk and ancillary treatments. initial study 9297 patients, 174 centers and 4528 patients agreed further follow-up. The rates of use of angiotensin-converting-enzyme inhibitors (ACEIs) in the 2 groups (72% ramipril versus 68% placebo) were similar after the end of the trial. During the posttrial follow-up, patients allocated to ramipril had a 19% further lower relative risk (RR) of myocardial infarction (95% confidence interval [CI], 0.65 to 1.01), a 16% lower RR (95% CI, 0.70 to 0.99) of revascularization, and a 34% lower RR of a new diagnosis of diabetes (95% CI, 0.46 to 0.95). Similar RR reductions in vascular events were observed during and after the active phase of the trial, regardless of baseline risk (RR of 0.76, 0.89, and 0.83 for low-, medium-, and high-risk patients, respectively) or ancillary treatments (RR of 0.90 for aspirin, 0.76 for (cid:1) -blockers, and 0.84 for lipid-lowering medication). benefits of ramipril observed during the active period of the HOPE trial were maintained during posttrial follow-up for cardiovascular death, stroke, and hospitalization for heart failure. Additional reductions in myocardial infarction, revascularization, and the development of diabetes were observed during the follow-up phase despite similar rates of ACEI use in the 2 randomized groups. These benefits were consistent regardless of patient risk or ancillary treatments. ( Circulation . 2005;112:1339-1346.) originally assigned to ramipril and 2211 originally assigned to placebo) who to participate in the study extension and refers to the extension only. The median duration of follow-up for this analysis was 2.6 years. Survival curves were estimated according to the Kaplan-Meier procedure, and treatment groups were compared by the log-rank test. All analyses were performed according to the intention-to-treat principle, were based on the original treatment allocation, and were stratified for treatment allocation to vitamin E versus placebo to account for the factorial study design (there was no interaction between ramipril and vitamin E for any of the end points analyzed), and the level of significance was set at 2 (cid:2) (cid:2) 0.05.
Improving data transfer rate of Hadoop MapReduce framework using data blocks for massive data

- In this research paper, a new technique has been proposed to process the massive data in Hadoop MapReduce framework to improve data rate by using synchronous data transmission, sending block of data from source to destination. The proposed method shows how to divide the data blocks in an efficient manner for achieving satisfactory data transfer rate by adjusting the split size or using appropriate size of staffs. In traditional system, normally data transfer is accomplished through a small block of 8 bit while in the proposed system data transfer is performed through a block size of 80 byte to 132 byte. Moreover, the traditional system needs to add 3 extra bits with a block of data during data transmission while the proposed system attaches additional 32 byte with a block of data. For this reason, our proposed system takes more time to transfer small size data but it transfer big size data very faster than the current systems. From the simulation results, it is observed that the proposed model is more efficient and provides satisfactory performance for the big size data
Supervision of Heterogeneous e-Learning Environments: the case of the International E-MI@GE Project Supervision of International E-MI@GE

— The International E-Miage project (IEM) is an engineering curriculum composed of more than twenty international sites that deliver official French degrees. The IEM computational environment comprises many tools, platforms and users that make it very difficult to establish an up-to-date global overview of the whole set of learning entities implied into this digital campus. Therefore, we present in this paper a tracking framework able to produce, exchange and store in a unified way all activities performed by users on the various IEM learning systems and resources. A rich Internet application has been designed to demonstrate how the collected data can be computed to build a real-time and detailed cartography of each IEM partner, or to produce useful statistics information about a (set of) partner.
ASSESSMENT OF QUALITY OF LIFE AND RISK FACTORS IN PATIENTS WITH DIABETIC FOOT ULCER Patients

of the was to assess the impact of on the quality of life of subjects with Diabetic ulcer. Diabetic foot ulcer causes changes in the daily lives of patients, creates limitations to perform daily activities and an enormous on the quality of life both and The also to determine the risk factors contributing to the development of Diabetic foot ulcer. A in study. The mean of the study was In the obtained mean and standard deviation of total QOL of patients was Also, there was a significant association found between the variables gender, BMI and presence of neuropathy with the QOL The major risk factors identified towards the development of DFU are Peripheral Neuropathy (66.66%), lack of foot care (76.19%) and poorly controlled blood sugar level (61.90%). The study found out that the quality of life and its dimension in patients with DFU's are in low range. While health education is a fundamental obligation of health care professional it is paramount that patients adopt the guidelines of feet care and integrate them into daily life in trying to prevent diabetic foot and its consequences. score of DFS QOL subscales. Mann-Whitney U test was used to find the association between the mean scores of domains of DFS and gender. The data collected for the study was analysed statistically by using the statistical program for social sciences (SPSS version 20). The results were expressed in 95% confidence interval. The results were also presented in the form of frequency format and diagrammatic representation whenever necessary. For inferential statistics the relationship between quality of life and variables (Age, Gender, Presence of Neuropathy, greater BMI), the results were considered statistically significant whenever the p-value was less than 0.05.
Contrasting behavior of the p18 INK4c and p16 INK4a tumor suppressors in both replicative and oncogene-induced senescence

The CDK inhibitors, p18 INK4c and p16 INK4a , both have the credentials of tumor suppressors in human cancers and mouse models. For p16 INK4a , the underlying rationale is its role in senescence but the selective force for inactivation of p18 INK4c in incipient cancer cells is less clear. Here we show that in human fibroblasts undergoing replicative or oncogene-induced senescence, there is a marked decline in the levels of p18 INK4c protein and RNA, which mirrors the accumulation of p16 INK4a . Downregulation of INK4c is not dependent on p16 INK4a and RAS can promote the loss of INK4c without cell cycle arrest. Down-regulation of p18 INK4c correlates with reduced expression of menin and E2F1 but is unaffected by acute cell cycle arrest or inactivation of the retinoblastoma protein (pRb). Collectively, our data question the idea that p18 INK4c acts as a backup for loss of p16 INK4a and suggest that the apparent activation of p18 INK4c in some settings represents delayed senescence rather than increased expression. We propose that the contrasting behavior of the two very similar INK4 proteins could reflect their respective roles in senescence versus differentiation.
An On-Demand Single-Electron Time-Bin Qubit Source

We propose a source capable of on-demand emission of single electrons with a wave packet of controllable shape and phase. The source consists of a hybrid quantum system, relying on currently experimentally accessible components. We analyze in detail the emission of single electron time-bin qubits, which we characterize using the well known electronic Hong-Ou-Mandel (HOM) interferometry scheme. Specifically, we show that, by controlling the phase difference of two time-bin qubits, the Pauli peak, the electronic analogue of the well known optical HOM dip, can be continuously removed. The proposed source constitutes a promising approach for scalable solid-state architectures for quantum operations using electrons and possibly for an interface for photon to electron time-bin qubit conversion.
Comprehensive assessment of T-cell receptor (cid:1) -chain diversity in (cid:2)(cid:1) T cells

The adaptive immune system uses several strategies to generate a repertoire of T- and B-cell antigen receptors with sufﬁcient diversity to recognize the uni-verseofpotentialpathogens.In (cid:1)(cid:2) T cells, which primarily recognize peptide antigens presented by major histocompatibility complex molecules, most of this receptor diversity is contained within the third complementarity-determining region (CDR3) of the T-cell receptor (TCR) (cid:1) and (cid:2) chains. Although it has been estimated that the adaptive immune system can generate up to 10 16 distinct (cid:1)(cid:2) pairs, direct assessment of TCR CDR3 diversity has not proved amenable to standard capillary electrophoresis-based DNA sequencing. We developed a novel experimentalandcomputationalapproach to measure TCR CDR3 diversity based on single-molecule DNA sequencing, and usedthisapproachtodeterminetheCDR3 sequence in millions of rearranged TCR (cid:2) genes from T cells of 2 adults. We ﬁnd that total TCR (cid:2) receptor diversity is at least 4-fold higher than previous estimates, and the diversity in the subset of CD45RO (cid:3) antigen-experienced (cid:1)(cid:2) T cells is at least 10-fold higher than previous estimates. These methods should prove valuable for assessment of (cid:1)(cid:2) T-cell repertoire
Normally-off integrated jfet power switches in wide bandgap semiconductors and methods of making

A normally-wide-band gap semiconductor device comprising an integrated power VJFET off switch is described. The power switch can be implemented in a hybrid or monolithic Riddick to, single or multi-can be integrated with the control circuit built in the chip wide band gap power semiconductor module. Devices are high-power, high-temperature-resistant may be used for the electronic component, and radiation resistance. How to make the device are also described.
University of Birmingham Observation of the Doubly Charmed Baryon cc + +

A highly significant structure is observed in the Λ þ c K − π þ π þ mass spectrum, where the Λ þ c baryon is reconstructed in the decay mode pK − π þ . The structure is consistent with originating from a weakly decaying particle, identified as the doubly charmed baryon Ξ þþ cc . The difference between the masses of the Ξ þþ cc and Λ þ c states is measured to be 1334 . 94 (cid:2) 0 . 72 ð stat : Þ (cid:2) 0 . 27 ð syst. Þ MeV =c 2 , and the Ξ þþ cc mass is then determined to be 3621 . 40 (cid:2) 0 . 72 ð stat : Þ (cid:2) 0 . 27 ð syst. Þ (cid:2) 0 . 14 ð Λ þ c Þ MeV =c 2 , where the last uncertainty is due to the limited knowledge of the Λ þ c mass. The state is observed in a sample of proton-proton collision data collected by the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1 . 7 fb − 1 , and confirmed in an additional sample of data collected at 8 TeV.
The Tourism Industry Competitive Potential Management

The tourist branch enterprises competitiveness aspects are considered in the article. Major strategic opportunities for the development industry as well as disadvantages are specified. The competitiveness indices of the countries, which are formed in the components and are consolidated into the subindex, are singled out. The changes in the positions of Ukraine and some countries of the world in the competitiveness index in the tourism sector are analyzed. The properties of competitive advantages are considered and divided into internal and external ones.
Mild Concussive Head Injury Results in Increased Brain Substance P Immunoreactivity

The neuroinflammatory neuropeptide substance P (SP) has been im-plicated in oedema development following traumatic brain injury. Whether the neuropeptide plays a role in concussive head injury is unknown. Accordingly, we have used a newly developed model of mild head injury in rats to characterise the release of SP following concussive brain injury. Following brain trauma, there was no evidence of motor or cognitive deficits over the ensuing 3 weeks. Despite this, increased SP immunoreactivity was present in perivascular axons, some pyramidal neurones and astrocytes when compared to sham animals. Our findings suggest that concussive brain injury predisposes an individual to diffuse brain swelling, which may have implications in the management of sports related concussion.
Quarks in a Box

The determination of the masses of the light quarks requires solving the hadronic binding prob- lem of quantum chromodynamics (QCD), the fundamental theory describing the strong interactions between the quarks. Due to asymptotic freedom, the high-momentum sector of QCD can be treated by perturbative methods, however, on the low energy hadronic scale the running coupling of QCD becomes large. As a consequence, perturbative methods are not adequate for the hadronic binding problem, the scenario of which is dominated by the QCD vacuum state. The only known way to solve rather than model the problem is through ab-initio numerical sim- ulations by high-end computers on a (cid:2)nite discrete space-time lattice. In this paper, which is intended for a non-expert audience, we give an illustrated introduction to the hadronic binding problem and its treatment by computer simulation on Tera-scale computers. We focus on the (cid:2)nite-size approach as pursued by the GRAL project to G o to more R ealistic A nd L ighter quark masses, the main obstacle to current simulations.
Growth, production and water use eﬃ­ ciency of chicory ( Cichorium endivia L.) in hydroponic systems using brackish waters

: Plants response to the same level of salinity can be increased in hydroponic cultivation compared to under soil conditions. The study aimed at evaluating the chicory growth in DFT (Deep Flow Technique) hydroponic system using brackish water, comparing the results with those obtained in NFT (Nutrient Film Technique) system. The experiment was carried out in a random­ ized block design with eight replicates. Each plot (replicate) was represented by a hydroponic channel with 15 plants. Four treatments were used, consisting of plants grown in the DFT system submitted to three levels of electrical conduc­ tivity of nutrient solution ­ ECsol (2.57, 3.43 and 4.75 dS/m) and in the NFT sys­ tem under ECsol of 2.57 dS/m. Plant height, number of leaves, fresh and dry matter of shoot, water consumption, water use eﬃciency and water content in shoot at 20 and 25 days after transplanting (DAT) were evaluated. In each har­ vest, a mean value was obtained per plot through of the harvest collection of ﬁve plants. At 25 DAT, the largest reductions in production and water use eﬃ­ ciency of chicory were observed under higher salinity (ECsol 4.75 dS/m). In the DFT system no symptoms of toxicity that could be attributed to salinity were
An Endoplasmic Reticulum Stress Response in Arabidopsis Is Mediated by Proteolytic Processing and Nuclear Relocation of a Membrane-Associated Transcription Factor, bZIP28

Stresses leading to the accumulation of misfolded proteins in the endoplasmic reticulum (ER) elicit a highly conserved ER stress response in plants called the unfolded protein response (UPR). While the response itself is well documented in plants, the components of the signaling pathway are less well known. We have identiﬁed three membrane-associated basic domain/ leucine zipper (bZIP) factors in Arabidopsis thaliana that are candidates for ER stress sensors/transducers. One of these factors, bZIP28, an ER-resident transcription factor, is activated in response to treatment by tunicamycin (TM), an agent that blocks N-linked protein glycosylation. Following TM treatment, bZIP28 is processed, releasing its N-terminal, cytoplasm-facingdomain,whichistranslocatedtothenucleus. Expressionofatruncated formofbZIP28,containingonlythecytoplasmic domain of the protein, upregulated the expression of ER stress response genes in the absence of stress conditions. Thus, bZIP28 serves as a sensor/transducer in Arabidopsis to mediate ER stress responses related to UPR. ofplantcellsisparticularlysensitivetostress,anddisturbancesin