Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing the Clinical Robustness of Digital Health Startups: Cross-sectional Observational Analysis

Background The digital health sector has experienced rapid growth over the past decade. However, health care technology stakeholders lack a comprehensive understanding of clinical robustness and claims across the industry. Objective This analysis aimed to examine the clinical robustness and public claims made by digital health companies. Methods A cross-sectional observational analysis was conducted using company data from the Rock Health Digital Health Venture Funding Database, the US Food and Drug Administration, and the US National Library of Medicine. Companies were included if they sell products targeting the prevention, diagnosis, or treatment phases of the care continuum. Clinical robustness was defined using regulatory filings and clinical trials completed by each company. Public claims data included clinical, economic, and engagement claims regarding product outcomes made by each company on its website. Results A total of 224 digital health companies with an average age of 7.7 years were included in our cohort. Average clinical robustness was 2.5 (1.8 clinical trials and 0.8 regulatory filings) with a median score of 1. Ninety-eight (44%) companies had a clinical robustness score of 0, while 45 (20%) companies had a clinical robustness score of 5 or more. The average number of public claims was 1.3 (0.5 clinical, 0.4 economic, and 0.4 engagement); the median number of claims was 1. No correlation was observed between clinical robustness and number of clinical claims (r2=0.02), clinical robustness and total funding (r2=0.08), or clinical robustness and company age (r2=0.18). Conclusions Many digital health companies have a low level of clinical robustness and do not make many claims as measured by regulatory filings, clinical trials, and public data shared online. Companies and customers may benefit from investing in greater clinical validation efforts.
Remote Control Smart Home System

The invention discloses a robot control smart home system, and relates to the technical field of smart home. The robot control smart home system comprises a movable robot, a processing terminal and ahome device. The movable robot is in communication connection with the processing terminal. The processing terminal is in communication connection with the home device. The movable robot is used for obtaining a user instruction and transmitting the user instruction to the processing terminal. The processing terminal is used for processing the user instruction and generating a control instruction according to the user instruction. The processing terminal is used for transmitting the control instruction to the home device. The home device is used for executing actions according to the control instruction. The robot control smart home system is used for effectively and conveniently controlling the smart home, the use experience of a user can be improved, and the control over the smart home ismore intelligent and convenient.
Distribution of Astigmatism among School Children Who Fail Vision Screening in South India

ABSTRACT Purpose The purpose of this study is to report the distribution of astigmatism among school children in South India. Methods The study was conducted as part of a national school eye screening project named ‘Refractive Error Among Children’ (REACH) between 6 and 17 years of age. Children underwent presenting visual acuity screening, external eye examination, screening for color vision deficiency, and non-strabismic binocular vision anomalies. Those who failed screening underwent, objective and subjective refraction, and identification of other ocular conditions. Astigmatism was defined as cylindrical power greater than 0.50D. Refractive errors were classified into myopia (≤0.50D), hyperopia (≥0.75D), and other refractive errors (between −0.50D and +0.75D). The data on astigmatism were analyzed and were deduced into its vector components (M, J0 and J45). Descriptive statistics and regression analysis were performed. Results Data of 245,565 children from 1047 schools were taken for analysis. The average age was 11.63 ± 3.32 (range:6–17) years. After screening, refractive errors and astigmatism was found to be 6.57% (n = 16157) and 3.69% (n = 9064), respectively. Astigmatism among children aged 6 to 10 years was 1.37%. The mean cylindrical power, J0, and J45 was found to be 1.93 ± 1.06D, 0.06 ± 0.59D, and 0.43 ± 0.81D, respectively. Linear regression showed a decreasing trend in the cylindrical component (p < .001) and shift towards less positive J0 values (p < .001). Higher proportions of astigmatism more than 1.50 D (1.83%,n = 4578) and unilateral astigmatism (1.20%,n = 2952) are evident among refractive errors. Conclusion More than 50% of children who failed vision screening with refractive errors presented with astigmatism. Prevalence was higher among primary school children. Presence of higher magnitude and unilateral astigmatism is amblyogenic and needs early intervention.
MakerWear: A Tangible Construction Kit for Young Children to Create Interactive Wearables

Title of Thesis: MAKERWEAR: A TANGIBLE CONSTRUCTION KIT FOR YOUNG CHILDREN TO CREATE INTERACTIVE WEARABLES SeyedMajeed Kazemitabaar, Master of Science, 2017 Thesis directed by: Dr. Jon E. Froehlich Department of Computer Science Wearable construction toolkits have shown promise in broadening participation in computing and empowering users to create personally meaningful computational designs. However, these kits present a high barrier of entry for some users, particularly young children (K-6). In this thesis, we introduce MakerWear, a new wearable construction kit for children that uses a tangible, modular approach to wearable creation. We describe our participatory design process, the iterative development of MakerWear, and results from singleand multi-session workshops with 32 children (ages 5-12; M=8.3 years). Our findings reveal how children engage in wearable design, what they make (and want to make), and what challenges they face. As a secondary analysis, we also explore age-related differences. MAKERWEAR: A TANGIBLE CONSTRUCTION KIT FOR YOUNG CHILDREN TO CREATE INTERACTIVE WEARABLES
Phenotypic characterization of human peripheral γδT‐cell subsets in glioblastoma

The antitumoral contribution of γδT cells depends on their activation and differentiation into effectors. This depends on different molecules and membrane receptors, which conditions their physiology. This study aimed to determine the phenotypic characteristics of γδT cells in glioblastoma (GBM) according to five layers of membrane receptors. Among ten GBM cases initially enrolled, five of them who had been confirmed by pathological examination and ten healthy controls underwent phenotyping of peripheral γδT cells by flow cytometry, using the following staining: αβTCR, γδTCR, CD3, CD4, CD8, CD16, CD25, CD27, CD28, CD45, CD45RA, CD56, NKG2D, CD272(BTLA), and CD279(PD‐1). Compared with the controls, the results showed no significant change in the number of γδT cells. However, there was a decrease of double‐negative (CD4−CD8−) Tγδ cells and an increase of naive γδT cells, a lack of CD25 expression, a decrease of the expression of CD279, and a remarkable, but not significant, increase in the expression of the CD27 and CD28 costimulation markers. Among the γδT cell subsets, the number of Vδ2 decreased in glioblastoma and showed no significant difference in the expression of CD16, CD56, and NKG2D. In contrast, the number of Vδ1 increased in glioblastoma with overexpression of CD16, CD56, and NKG2D. Our results showed that γδT cells are prone to adopt a pro‐inflammatory profile in the glioblastoma context, which suggests that they might be a potential tool to consider in T cell‐based immunotherapy in glioblastoma. However, this requires additional investigation on a larger sample size.
Revisiting the therapeutic potential of tocotrienol

The therapeutic potential of the tocotrienol group stems from its nutraceutical properties as a dietary supplement. It is largely considered to be safe when consumed at low doses for attenuating pathophysiology as shown by animal models, in vitro assays, and ongoing human trials. Medical researchers and the allied sciences have experimented with tocotrienols for many decades, but its therapeutic potential was limited to adjuvant or concurrent treatment regimens. Recent studies have focused on targeted drug delivery by enhancing the bioavailability through carriers, self‐sustained emulsions, nanoparticles, and ethosomes. Epigenetic modulation and computer remodeling are other means that will help increase chemosensitivity. This review will focus on the systemic intracellular anti‐cancer, antioxidant, and anti‐inflammatory mechanisms that are stimulated and/or regulated by tocotrienols while highlighting its potent therapeutic properties in a diverse group of clinical diseases.
The clinical outcomes of mixed engraftment patients treated with haploidentical stem cells combined with umbilical cord blood transplantation

Yujie Liu , Lijuan Qi , Tanzhen Wang , Biqi Zhou, Jia Chen, Jinyan Xiao, Yanglan Fang, Qiannan Yang, Yufeng Feng, Depei Wu and Yang Xu Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, PR China; Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, PR China
Video‐blogs and linguistic simplification for students with intellectual disability

Abstract Background The Internet provides individuals with intellectual disability with access to information and participation in a broader society, but it also presents risks when content is difficult to comprehend. This study aimed to test whether students with intellectual disability enhanced their comprehension of online blogs as a function of the format (text vs. video) and linguistic simplification. Method Young students with intellectual disability read or watched text and video‐blog posts about environment, health, society, and technology in their original version or a linguistically simplified/easy‐to‐read version. Then, they completed tests that assessed their reading processing (e.g., calibration) and comprehension of blog content. Results Participants predicted that they would correctly answer 80% of the comprehension questions, but their average comprehension of the blog posts was 55%, regardless of the condition. Previous levels of students' reading comprehension skills predicted their blog comprehension scores and interacted with format and simplification. Those participants with higher reading comprehension skills learned more from non‐simplified than from simplified blog posts while those with lower levels of reading comprehension skills did not benefit from linguistic simplification nor video‐blog format although the difference with regard to higher comprehenders was lower in the video and simplified conditions. Conclusions Improving reading comprehension abilities of students with intellectual disability is essential to prevent the digital divide while linguistic simplification is not a useful accommodation and even counterproductive for higher reading comprehenders.
The prognostic impact of myosteatosis on overall survival in gynecological cancer patients: A meta‐analysis and trial sequential analysis

Myosteatosis is a novel imaging biomarker for survival in gynecological cancer patients; however, the evidence is inconsistent. This meta‐analysis aims to investigate the impact of myosteatosis on overall survival in the gynecological oncology setting. Three databases (PubMed, EMBASE and Web of Science) were systematically searched for relevant literature up to October 30, 2021. A random‐effects model was used to evaluate the predictive effect of myosteatosis on overall survival in the gynecological cancer population. The Newcastle‐Ottawa Scale was used to assess the methodological quality of the included studies. Trial sequential analysis was used to control the risk of random errors. Twelve studies with a total of 2519 patients were included. Myosteatosis was associated with a 50% increased mortality risk (HR 1.50, 95% CI 1.24‐1.82, P < .001) in gynecological cancer patients. Subgroup analyses stratified by study design, statistical model, treatment, sample size and stage confirmed the predictive value of myosteatosis on survival. However, the prognostic ability of myosteatosis only was held in the American and European populations but lost in Asians. Additionally, myosteatosis was not associated with the increased mortality in endometrial and cervical cancers, except for ovarian cancers. Overall, myosteatosis is a powerful predictor of reduced overall survival in gynecological cancer patients.
Evaluating Equity Through the Social Determinants of Hearing Health

Hearing loss in adults is a significant public health problem throughout the world. Undiagnosed and untreated hearing loss causes a measurable impact on health and social, occupational, and emotional well-being of those affected. In spite of a wide array of health care resources to identify and manage hearing loss, there exist vast disparities in outcomes, as well as access to and utilization of hearing healthcare. Hearing rehabilitation outcomes may vary widely among different populations and there is a pressing need to understand, in a broader sense, the factors that influence equitable outcomes, access, and utilization. These factors can be categorized according to the widely accepted framework of social determinants of health, which is defined by the World Health Organization as “the conditions in which people are born, grow, work, live, and age. ” According to Healthy People 2030, these determinants can be broken into the following domains: healthcare access and quality, education access and quality, social and community context, economic stability, and neighborhood and built environment. This article defines these domains and examines the published research and the gaps in research of each of these domains, as it pertains to hearing health and healthcare. Herein, we review foundational sources on the social determinants of health and hearing-related research focused on the topic. Further consideration is given to how these factors can be evaluated in a systematic fashion and be incorporated into translational research and hearing health care.
Molecular and clinical descriptions of patients with GABAA receptor gene variants ( GABRA1, GABRB2, GABRB3, GABRG2 ): A cohort study, review of literature, and genotype–phenotype correlation

γ‐Aminobutyric acid (GABA)A‐receptor subunit variants have recently been associated with neurodevelopmental disorders and/or epilepsy. The phenotype linked with each gene is becoming better known. Because of the common molecular structure and physiological role of these phenotypes, it seemed interesting to describe a putative phenotype associated with GABAA‐receptor–related disorders as a whole and seek possible genotype–phenotype correlations.
Allometry in the corpus callosum in neonates: Sexual dimorphism

The corpus callosum (CC) is the largest fiber tract in the human brain, allowing interhemispheric communication by connecting homologous areas of the two cerebral hemispheres. In adults, CC size shows a robust allometric relationship with brain size, with larger brains having larger callosa, but smaller brains having larger callosa relative to brain size. Such an allometric relationship has been shown in both males and females, with no significant difference between the sexes. But there is some evidence that there are alterations in these allometric relationships during development. However, it is currently not known whether there is sexual dimorphism in these allometric relationships from birth, or if it only develops later. We study this in neonate data. Our results indicate that there are already sex differences in these allometric relationships in neonates: male neonates show the adult‐like allometric relationship between CC size and brain size; however female neonates show a significantly more positive allometry between CC size and brain size than either male neonates or female adults. The underlying cause of this sexual dimorphism is unclear; but the existence of this sexual dimorphism in neonates suggests that sex‐differences in lateralization have prenatal origins.
Estimation of fluid status using three multifrequency bioimpedance methods in hemodialysis patients

Segmental eight‐point bioimpedance has been increasingly used in practice. However, whether changes in bioimpedance analysis components before and after hemodialysis (HD) using this technique in a standing position is comparable to traditional whole‐body wrist‐to‐ankle method is still unclear. We aimed to investigate the differences between two eight‐point devices (InBody 770 and Seca mBCA 514) and one wrist‐to‐ankle (Hydra 4200) in HD patients and healthy subjects in a standing position.
TCHis mitigate oxidative stress and improve abnormal behavior in a prenatal valproic acid-exposed rat model of autism.

Objective Troxerutin is known for its anti-inflammatory and antioxidative effects in nerve impairment. The purpose of this study is to investigate the effect of troxerutin and cerebroprotein hydrolysate injections (TCHis) on prenatal valproic acid (VPA)-exposed rats. Methods The VPA was administered to pregnant rats on gestational day 12.5 to induce a model of autism. The offsprings were given the treatment of TCHis on postnatal day (PND) 21-50. On PND 43-50, the behavioral analysis of offsprings was performed after the treatment of TCHis for 1 h. On PND 50, the offsprings were harvested and the brains were collected. The hippocampus and prefrontal cortex were isolated for relevant biochemical detections. Results The administration of TCHis increased the pain sensitivity and improved abnormal social behaviors in prenatal VPA-exposed rats. Prenatal expose of VPA induced neuronal loss and apoptosis, enhanced reactive oxygen species (ROS) production, and promoted oxidative stress in hippocampus and prefrontal cortex, while these effects were reversed by the postnatal treatment of TCHis. In addition, postnatal administration of TCHis ameliorated mitochondrial function in hippocampus and prefrontal cortex of prenatal VPA-exposed rats. Conclusion This study concluded that postnatal treatment of TCHis reduced oxidative stress and ameliorated abnormal behavior in a prenatal VPA-induced rat model of autism.
VivoPartial Reduction in Regulatory T Cells In Metastatic Melanoma Induces a Selective Immunotoxin, LMB-2, to Patients with Administration of a CD25-Directed

CD25 (cid:1) CD4 (cid:1) T regulatory (Treg) cells regulate peripheral self tolerance and possess the ability to suppress antitumor responses, which may in part explain the poor clinical response of cancer patients undergoing active immunization protocols. We have previously shown that in vitro incubation of human PBMC with LMB-2, a CD25-directed immunotoxin, signiﬁcantly reduced CD25 (cid:1) FOXP3 (cid:1) CD4 (cid:1) Treg cells without impairing the function of the remaining lymphocytes. In the current study, eight patients with metastatic melanoma were treated with LMB-2 followed by MART-1 and gp100-speciﬁc peptide vaccination. LMB-2 administration resulted in a preferential, transient reduction in mean circulating CD25 (cid:1) CD4 (cid:1) T cell number, from 83 (cid:2) 16 cells/ (cid:3) l to a nadir of 17 (cid:2) 5 cells/ (cid:3) l, a 79.1% reduction. FOXP3 analysis revealed a less robust depletion with mean FOXP3 (cid:1) CD4 (cid:1) Treg cell number decreasing from 74 (cid:2) 15 cells/ (cid:3) l to 36 (cid:2) 8 cells/ (cid:3) l, a 51.4% reduction. FOXP3 (cid:1) CD4 (cid:1) Treg cells that survived LMB-2-mediated cytotoxicity expressed little or no CD25. Similar to the peripheral blood, immunohistochemical analysis showed a 68.9% mean reduction in FOXP3 (cid:1) CD4 (cid:1) Treg cell frequency in evaluable lesions. Despite inducing a reduction in Treg cell numbers in vivo, LMB-2 therapy did not augment the immune response to cancer vaccination and no patient experienced an objective response or autoimmunity. These data demonstrate the capacity of a CD25-directed immunotoxin to selectively mediate a transient partial reduction in circulating and tumor-inﬁltrating Treg cells in vivo, and suggest that more comprehensive Treg cell elimination may be required to bolster antitumor responses in patients with metastatic melanoma. The Journal of Immunology, 2007, 179: 4919–4928.
MESTRADO EM: ECONOMIA MONETÁRIA E FINANCEIRA EXCESS RETURNS AND NORMALITY

In this dissertation, I assess under which circumstances normality can be a good descriptive model for the U.S. excess returns. I explore two possible sources of deviations from normality: structural breaks and regime switching in long term aggregate time series. In addition, I study temporal aggregation (i.e., considering the frequency of data as a variable) for excess returns in short term time series. My main findings are summarized as follows. First, using long spanning monthly time series data from 1871 to 2010, I find that (1) there are structural breaks in monthly excess returns between pre-WWII and post-WWII data; and, (2) while pre-WWII data is consistent with normality, post-WWII data is not. Second, I provide evidence of two market regimes for excess returns in post-WWII data. These regimes may be seen as bull and bear market conditions. Third, using high frequency post-WWII data, I check for aggregational Gaussianity, from daily to annual data. I find that Gaussianity depends on the frequency of data: it may hold for highly aggregate data (starting from semi-annual to annual data) but it does not hold for high frequency data (less than semi-annual). My main contribution is to demonstrate the ”normality survival” when frequency is taken as a variable. After a careful look at the available literature on aggregational Gaussianity, I found no previous applications and results for excess returns.
CMAR_A_279831 1699..1708

1Obstetrics and Gynecology Hospital, Fudan University, Shanghai, People’s Republic of China; 2Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, People’s Republic of China; 3Institutes of Biomedical Sciences of Shanghai Medical School, Fudan University, Shanghai, People’s Republic of China; 4Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, People’s Republic of China
COMPARISON OF COLLOID (POLYGELINE) OVER CRYSTALLOID (LACTATED RINGER) PRELOADING IN PREVENTING HYPOTENSION IN PATIENTS UNDERGOING CAESAREAN-SECTION UNDER SPINAL ANAESTHESIA

Objective: To assess efficacy of colloid (Polygeline) over crystalloid (Lactated Ringer) preloading in preventing hypotension in patients undergoing caesarean-section under spinal anaesthesia. Study design: Randomized control trial. Settings: The study was conducted in department of Anesthesiology and Intensive care Combined Military Hospital Peshawar over a period of 6 months from 01 March 2007 to 31 August 2007. Material and Methods: One hundred patients fulfilling the inclusion criteria were selected for study and divided into two groups of 50 each. Group A was given 500 ml Polygeline as preloading solution while group B received 1 liter of Ringer’s Lactate as preloading solution just before administration of spinal anaesthesia. Heart rate and systolic blood pressure were recorded at 01 min, 05 mins, 10 mins, 15 mins, 20 mins, 30 mins and 45 mins after the performance of spinal block. Dose of ephedrine given to treat hypotension after the block was also recorded. Results: There was significant difference in terms of heart rate and systolic arterial pressure 1 and 5 minutes after block between both the groups. There was also significant difference in terms of dose of ephedrine between both the groups. Conclusion: Polygeline is more effective than Ringer’s Lactate as preloading fluid in preventing hypotension for caesarean section under spinal anaesthesia.