Miracle-dz/UniFAR-FTUs huggingface dataset:
Orbit and properties of the massive X-ray binary BD +60 73=IGR J00370+6122

Context. High-energy X-rays generated in massive binary systems can arise from several different mechanisms. Constraints on the orbital parameters of these systems are therefore necessary to properly understand and interpret the X-ray phenomena. Aims. In this study we aim to determine a spectroscopic orbit for the high-mass X-ray binary system BD +60 73=IGR J00370+6122, to infer the properties of the optical and compact companion, and to interpret the characteristics of the X-ray light curve within the context of our findings. Methods. We acquired 123 spectroscopic observations with the David Dunlap Observatory and Kitt Peak National Observatory telescopes in the optical domain. Using a cross-correlation technique, we measured the radial velocity of each of these spectra relative to the heliocentric rest-frame. An orbital solution was obtained from the resulting radial velocity measurements. Spectra of several spectral standards were also acquired to reassess the spectral classification of the optical companion. Results. The best-fit orbital parameters suggest an eccentricity of e = 0.48 +0.02 −0.03 and a mass-function of f(M) = 0.009 ±0.002, lending further support to the assumption that the companion is a low-mass compact star. We find that the X-ray maximum occurs just after the time of periastron passage, but before the time of superior conjunction when the optical companion could eclipse the compact companion. The spectrum of the optical companion is best matched by the B1Ib spectral standard HD24398, which reaffirms the original classification. Conclusions. The mass-function combined with a plausible range of possible masses for a neutron star companion yields primary masses within the range expected for the spectral type of BD +60 73 for high orbital inclinations. The compact companion cannot be a black hole unless the supergiant has an exceptionally high mass for its B1Ib spectral type or if the inclination of its orbit is very low. The X-ray timing and characteristics can potentially be explained by accretion variations on the compact object; but this would require the companion to be a magnetar.
Absolute radiometric calibration accuracy of the Atmospheric Infrared Sounder (AIRS)

The Atmospheric Infrared Sounder (AIRS) on the EOS Aqua Spacecraft was launched on May 4, 2002. AIRS has demonstrated in-flight NIST traceability and high radiometric accuracy. This accuracy is achieved in orbit by transferring the calibration from a Large Area Blackbody (LABB) to the On-Board Calibrator (OBC) blackbody during preflight testing. The LABB theoretical emissivity is in excess of 0.9999 and temperature uncertainty is less than 30 mK. The LABB emitted radiance is NIST traceable through precision Platinum Resistance Thermometers (PRTs) located on the internal surfaces. The radiometric accuracy predictions for AIRS based on the OBC, LABB, and pre-flight measurements give an accuracy of 0.2K, 3 sigma. AIRS pre-flight calibration coefficients have not changed in flight, preserving the link between observations and pre-flight calibration and characterization. An update is being considered that will improve accuracy and preserve traceability.
Upregulation of miR-142 in papillary thyroid carcinoma tissues: a report based on in silico and in vitro analysis

Papillary thyroid carcinoma (PTC) accounts for approximately 80% of all human thyroid malignancies. Recently, there has been a dramatic rise in the prevalence of thyroid cancer all over the globe. Through analysis of the GEO database, GSE104005, the authors of the current research were able to determine the differential expression of microRNAs (DEMs) as well as their target genes. Real-time PCR was used on a total of 40 samples, 40 of which were from PTC samples and 40 from normal tissues, in order to validate the discovered DEMs and the genes. Gene Ontology (GO) categories were identified, and KEGG was used to conduct pathway enrichment analysis. The multiMiR R package was used to predict target genes of DEMs. Mir-142 was found to be overexpressed in PTC samples, as compared to normal tissues, and this was validated by the identification and validation. In addition, metal ion binding and the cellular response to metal ions were identified as essential pathways in the carcinogenesis of PTC. This demonstrates their significance in the development of this malignancy. The results of our research will serve as the foundation for further research in the area of miRNA-based cancer treatment.
Drug‐Drug Interactions in Elderly Adults in Dentistry Care: a Cross-Sectional Study

Statement of the Problem: Given the increase in the population of the elderly patients and the risk of systemic diseases in these individuals, the prevalence of the intake of various drugs is higher in elderly patients, which exposes them to the side effects of drugs including potential drug-drug interactions (DDIs). Purpose: Therefore, the present study is an attempt to evaluate the drug interactions between the drugs used by the elderly patients visiting Kerman School of Dentistry and the common dental drugs in 2020. Materials and Method: This cross-sectional study was conducted on the elderly patients (≥60 years (who referred to Kerman School of Dentistry for dental problems. After obtaining the oral informed consent and collecting demographic information, the drugs used by the patients and their systemic diseases were questioned, listed, and compared with the drugs mentioned in their files. The drug interactions with the common dental drugs were studied in the elderly patients using the www.drugs.com website. Chi-square, T, ANOVA, Kruskal-Wallis, and Mann-Whitney tests were used to compare the variables. The significance level was 0.05. Results: Of participants included in this study, 78 (52%) were female and 72(48%) were male. The average age of these patients was 71.27 6.32 years. The most common systemic diseases were hypertension (57.3%), heart diseases (42.0%), and diabetes mellitus (40.7%). Our analysis of the DDIs between 11 commonly prescribed dental drugs and 95 drugs used by the patients revealed 212 DDIs (21.7% minor, 68.3% moderate, and 9.9% major interactions). There was a significant relationship between the number of drugs and DDIs, whereas DDIs had no significant relationship with gender and educational level. Conclusion: The results reflected the high percentage of DDIs among the patients. In addition, there was a significant relationship between polypharmacy, which is highly prevalent among the elderly patients, and drug interactions.
Upwind finite-difference calculation of traveltimes

Seismic traveltimes can be computed efficiently on a regular grid by an upwind finite‐difference method. The method solves a conservation law that describes changes in the gradient components of the traveltime field. The traveltime field itself is easily obtained from the solution of the conservation law by numerical integration. The conservation law derives from the eikonal equation, and its solution depicts the first‐arrival‐time field. The upwind finite‐difference scheme can be implemented in fully vectorized form, in contrast to a similar scheme proposed recently by Vidale. The resulting traveltime field is useful both in Kirchhoff migration and modeling and in seismic tomography. Many reliable methods exist for the numerical solution of conservation laws, which appear in fluid mechanics as statements of the conservation of mass, momentum, etc. A first‐order upwind finite‐difference scheme proves accurate enough for seismic applications. Upwind schemes are stable because they mimic the behavior of flu.
Impulse noise measurement in view of noise hazard assessment and use of hearing protectors

Experience shows the occurrence of situations when the measurements of impulse noise parameters are made with measurement equipment unsuitable for such conditions. The results of using such equipment were compared with the results of using equipment with a sufficiently large upper limit of the measurement range. The analysis was carried out on the example of noise generated during shots from a Mossberg smooth-bore shotgun and AKM rifle, as well as produced in the forge. The use of the unsuitable equipment allowed to indicate the exceeding of the exposure limit value of the peak value of the signal (LC peak), but this is not always possible when determining the energy properties of the signal (L EX,8h). While the inadequate properties of the measurement equipment will generally not prevent the conclusion that noise in a particular workplace is hazardous to hearing, the results of measurements cannot be used to select hearing protectors.
The Effectiveness of Mindful Hypnotherapy on Depression, Self-Compassion, and Psychological Inflexibility in Females with Major Depressive Disorder: A Single-Blind, Randomized Clinical Trial

ABSTRACT The effectiveness of the novel intervention mindful hypnotherapy on depression, self-compassion, and psychological inflexibility in females with major depressive disorder was examined in a randomized, clinical trial. Thirty-four participants were randomly allocated into mindful hypnotherapy and waitlist control groups. The intervention group was treated in 8 face-to-face, 60-minute weekly therapy sessions along with mindful hypnosis audio tapes to be used daily. The results of analysis of covariance indicated that there were significant differences between the mindful hypnotherapy and waitlist control groups after intervention and at 2-month follow-up (p < .001). The between-subject test of repeated measures ANOVAs also indicated a clinically significant difference between groups across time (baseline, postintervention, and 2-month follow-up) in depression, F = 53.86, p < . 001, effect size = . 65, and in self-compassion, F = 33.18, p < . 001, effect size = . 53, as well as psychological inflexibility, F = 26.84, p < . 001, effect size = . 48. In conclusion, this study indicates that mindful hypnotherapy is an effective intervention for treating depression as well as reducing psychological inflexibility and improving self-compassion for patients with major depressive disorder.
Pomegranate Peel Extract Sensitizes Hepatocellular Carcinoma Cells to Ionizing Radiation, Induces Apoptosis and Inhibits MAPK, JAK/STAT3, β-Catenin/NOTCH, and SOCS3 Signaling

Tumor resistance is typically blamed for the failure of radiotherapy and chemotherapy to treat cancer in clinic patients. To improve the cytotoxicity of tumor cells using radiation in conjunction with specific tumor-selective cytotoxic drugs is crucial. Pomegranate has received overwhelmingly positive feedback as a highly nutritious food for enhancing health and treating a variety of ailments. In the present study, we aimed to examine the effects as well as mechanism of action of pomegranate peel extract (PPE) and/or γ-radiation (6-Gy) on hepatocellular carcinoma (HCC) cell lines HepG2. The findings of this study showed that PPE treatment of HepG2 cells considerably slowed the proliferation of cancer cells, and its combination with γ-irradiation potentiated this action. As a key player in tumor proliferation, and inflammatory cascade induction, the down-regulation of STAT3 following treatment of irradiated and non-irradiated HepG2 cells with PPE as recorded in the present work resulted in reduction of tumor growth, via modulating inflammatory response manifested by (down-regulation of TLR4 expression and NFKB level), suppressing survival markers expressed by reduction of JAK, NOTCH1, β-catenin, SOCS3, and enhancing apoptosis (induction of tumor PPAR-γ and caspase-3) followed by changes in redox tone (expressed by increase in Nrf-2, SOD and catalase activities, and decrease in MDA concentration). In conclusion, PPE might possess a considerable therapeutic potential against HCC in addition to its capability to enhance response of HepG2 cells to gamma radiation,
Development and evaluation of the Food Bank Health and Nutrition Assessment

Abstract Objective: Efforts to improve the nutritional quality and health promotion in the charitable food system have been undertaken. Though methods exist to track these efforts in terms of food banks’ inventory, there are not research-tested tools to assess, monitor and influence policy, systems and environmental (PSE) changes. The study objective was to develop and evaluate a novel assessment tool that could be used to evaluate a food bank’s efforts to improve the promotion of health and nutritious foods. Design: The study had five phases: (1) initial development; (2) iterative review and revisions; (3) pilot testing; (4) content validity assessment and (5) inter-rater and test-retest assessment. The Food Bank Health and Nutrition Assessment (FB-HANA) was drafted after reviewing existing policies, nutrition-focused charitable food systems guidance and similar tools for food pantries. Setting: Midwestern United States. Participants: Eleven food banks. Results: Stakeholders and pilot testers provided initial feedback to refine the FB-HANA’s flow, ease of completion and collection of contextual information. External experts rated the FB-HANA and each of the eight objectives as content valid. A set of two assessments completed by twenty-six community-based professionals, employed by Extension and fourteen food bank staff across eleven food banks, supported moderate to excellent inter-rater and test-retest reliability for the FB-HANA overall and each of its objectives. Conclusions: Evidence suggests that the FB-HANA can be used by either food bank or community-based professionals, such as Extension staff, to provide a perspective on ways food banks promote health and nutrition through PSE approaches.
Acute Liver Failure: Biomarkers Evaluated by the Acute Liver Failure Study Group

There has been a growing interest in identifying prognostic biomarkers that alone or with available prognostic models (King’s College Criteria, KCC; MELD and ALFSG Prognostic Index) would improve prognosis in acute liver failure (ALF) patients being assessed for liver transplantation. The Acute Liver Failure Study Group (ALFSG) has evaluated 15 potential prognostic biomarkers: serum AFP; apoptosis-associated proteins; serum actin-free Gc-globulin; serum glycodeoxycholic acid; sRAGE/RAGE ligands; plasma osteopontin; circulating MBL, M-, L-, H-ficolin and CL-1; plasma galectin-9; serum FABP1; serum Lct2; miRNAs; factor V; thrombocytopenia, and sCD163. The ALFSG also has reported on 4 susceptibility biomarkers: keratins 8 and 18 (K8/K18) gene variants; polymorphisms of genes encoding putative APAP-metabolizing enzymes (UGT1A1, UGT 1A0, UGT 2B15, SULT1A1, CYP2E1, and CYP3A5) as well as CD44 and BHMT1; single nucleotide polymorphisms (SNPs) of genes associated with human behavior, rs2282018 in the arginine vasopressin (AVP) gene and rs11174811 in the AVP receptor 1A gene. Finally, rs2277680 of the CSCL16 gene in HBV-ALF patients. In conclusion, we have reviewed the prognostic and susceptibility biomarkers studied by the ALFSG. We suggest that a better approach to predicting the clinical outcome of an ALF patient will require a combination of biomarkers of pathogenic processes such as cell death, hepatic regeneration, and degree of inflammation that could be incorporated into prognostic models such as KCC, MELD or ALFSG PI.
Physical mechanism of effective work function modulation caused by impurity segregation at Ni silicide/SiO2 interfaces

An effective work function (Φeff) modulation caused by impurity doping in Ni-FUSI/SiO2 systems has been systematically investigated. To clarify the physical origin, we reveal the relationship between changes of Φeff modulation factors at gate electrode interfaces and Φeff modulation ranges (ΔΦeff) in two different doping processes (predoping and post-doping). In the predoping process, in which impurities (As or B) are implanted into polycrystalline Si gate before Ni fully silicided gate formation, both the crystal structure of the Ni silicide layer and the impurity concentration at the Ni silicide/SiO2 interface change depending on the impurity species. On the other hand, the impurity post-doping process, in which impurities are implanted and introduced to the Ni silicide/SiO2 interface after Ni silicide formation, makes it possible to introduce the desired amount of impurities into the interface without any structural change of the Ni silicide. In both cases, dependence of ΔΦeff on interface impurity con.
Recommendations for the Management of Incidental Musculoskeletal Findings on MRI and CT

The Canadian Association of Radiologists (CAR) Incidental Findings Working Group consists of both academic subspeciality and general radiologists tasked with either adapting American College of Radiology (ACR) guidelines to meet the needs of Canadian radiologists or authoring new guidelines where appropriate. In this case, entirely new guidelines to deal with incidental musculoskeletal findings that may be encountered on thoracoabdominal computed tomography or magnetic resonance imaging were drafted, focussing on which findings should prompt recommendations for further workup. These recommendations discuss how to deal with incidental marrow changes, focal bone lesions, abnormalities of the pubic symphysis and sacroiliac joints, fatty soft tissue masses, manifestations of renal osteodystrophy and finally discuss opportunistic osteoporosis evaluation.
The sweet side of wound healing: galectins as promising therapeutic targets in hemostasis, inflammation, proliferation, and maturation/remodeling

ABSTRACT Introduction Understanding the molecular and cellular processes involved in skin wound healing may pave the way for the development of innovative approaches to transforming the identified natural effectors into therapeutic tools. Based on the extensive involvement of the ga(lactoside-binding)lectin family in (patho)physiological processes, it has been well established that galectins are involved in a wide range of cell-cell and cell-matrix interactions. Areas covered In the present paper, we provide an overview of the biological role of galectins in repair and regeneration, focusing on four main phases (hemostasis, inflammation, proliferation, and maturation/remodeling) of skin repair using basic wound models (open excision vs. sutured incision). Expert opinion The reported data make a strong case for directing further efforts to treat excisional and incisional wounds differently. Functions of galectins essentially result from their modular presentation. In fact, Gal-1 seems to play a role in the early phases of healing (anti-inflammatory) and wound contraction, Gal-3 accelerates re-epithelization and increases tensile strength (scar inductor). Galectins have also become subject of redesigning by engineering to optimize the activity. Clinically relevant, these new tools derived from the carbohydrate recognition domain platform may also prove helpful for other purposes, such as potent antibacterial agglutinins and opsonins.
Autoimmune diseases as comorbidities for liver, gallbladder, and biliary duct cancers in Sweden

Autoimmune diseases are associated with many cancers but there is a lack of population‐based studies with different autoimmune diseases that have a long follow‐up. This is also true of hepatobiliary cancers, which include hepatocellular cancer (HCC) and rarer entities of gallbladder cancer (GBC), intra‐ and extrahepatic cholangiocarcinoma (iCCA and eCCA), and ampullary cancer.
Efficacy of zinc glycinate reducing zinc oxide on intestinal health and growth of nursery pigs challenged with F18+ Escherichia coli

Abstract The objective of this study was to investigate effects of zinc glycinate (ZnGly) supplementation reducing zinc oxide (ZnO) in feeds on intestinal health and growth of nursery pigs challenged with F18+Escherichia coli (E. coli). In total, 72 nursery pigs (BW 6.5 ± 0.5 kg) were allotted in a randomized complete block design to nine treatments: (1) NC: no challenge/no supplement; (2) PC: E. coli challenge/no-supplement; (3) E. coli challenge/ZnO at 2,500 mg/kg; (4, 5, and 6) E. coli challenge/ZnGly at 400, 800, and 1,200 mg/kg; and (7, 8, and 9) E. coli challenge/ZnGly at 400 mg/kg and ZnO at 700, 1,400, and 2,357 mg/kg. Pigs were fed for 28 d based on two phases (phase 1: 14 d and phase 2: 14 d). On day 7, challenged groups were orally inoculated with F18+E. coli at 6 × 109 CFU/mL whereas NC received saline solution. The PC showed reduced ADG (P = 0.076) and G:F (P = 0.055) during phase 1 and increased fecal score (P < 0.05) during the first week of postchallenge when compared with NC, whereas supplementation of ZnGly from 0 to 1,200 mg/kg linearly increased (P = 0.092) G:F and decreased (P < 0.05) the fecal score of the pigs challenged with F18+E. coli. Supplementation of ZnGly from 0 to 1,200 mg/kg had quadratic effects on TNF-α (P = 0.065; minimum 1.13 pg/mg at 850 mg/kg ZnGly), IL-8 (P = 0.093; minimum 0.53 ng/mg at 494 mg/kg), and protein carbonyl (P = 0.054; minimum 2.30 pg/mg at 675 mg/kg) and linearly increased mRNA expressions of ZIP4 (P = 0.057) and ZnT5 (P = 0.075) in the jejunum of the pigs. Supplementation of ZnGly from 0 to 1,200 mg/kg linearly increased (P < 0.05) the relative abundance of Actinobacteria and had quadratic effects on Cyanobacteria (minimum 0.67% at 625 mg/kg ZnO) and Proteobacteria (maximum 45.6 g/d at 735 mg/kg) at the phylum level, with linearly decreased (P < 0.05) Enterobacteriaceae at the family level in the jejunal mucosa-associated microbiota of the pigs. There was no difference in growth performance during the overall period, although pigs fed with ZnO at 2,500 mg/kg had greater (P < 0.05) ADG than pigs fed with ZnGly at 400 mg/kg during the first week of the post challenge period. In conclusion, ZnGly could be an alternative to the pharmaceutical use of ZnO without negatively affecting the growth of nursery pigs by enhancing intestinal Zn absorption, reducing intestinal inflammation and oxidative stress, and providing positive changes in jejunal mucosa-associated microbiota.
Parametric amplifiers driven by two pump waves

Parametric amplifiers (PAs) are well-suited for optical communication systems. Not only can PAs provide high gain for arbitrary signal wavelengths, they can also conjugate the signals and convert their wavelengths. The four-sideband model of parametric amplifiers driven by two pump waves will be reviewed and used to describe the conditions required to produce broad-bandwidth gain. The flexibility of the two-pump architecture allows it to produce gain that is nearly independent of the signal polarization, and idlers whose spectral widths are comparable to that of the signal.
What are scientifically valuable developments for ALMA enhancement?

The Atacama Large Millimeter/submillimeter Array (ALMA) is already producing a growing number of impressive and scientifically compelling results during its first two years of operation as the most powerful mm/submm interferometer in the world. However, ALMA still has some scientific weak points due to the technological limitations. In order to maintain ALMA as the state-of-the-art facility over the course of its projected life of 30+ years, continuing technical upgrades and developments for new capabilities are essential. We have already performed future development studies and projects for ALMA enhancement, which are the main development focus for the next 5 - 10 years. We should now start the discussion of the technical requirements and the potential science achievable with larger scale developments which are envisioned in the next 10 - 20 years, because it is emphasized that the larger scale project will likely result in higher impact, groundbreaking ALMA science in the year 2034 and beyond.