Miracle-dz/UniFAR-FTUs huggingface dataset:
Deregulation of the Replisome Factor MCMBP Prompts Oncogenesis in Colorectal Carcinomas through Chromosomal

Genetic instability has emerged as an important hallmark of human neoplasia. Although most types of cancers exhibit genetic instability to some extent, in colorectal cancers genetic instability is a distinctive characteristic. Recent studies have shown that deregulation of genes involved in sister chromatid cohesion can result in chromosomal instability in colorectal cancers. Here, we show that the replisome factor minichromosome maintenance complex–binding protein (MCMBP), which is directly involved in the dynamics of the minichromosome maintenance complex and contributes to maintainingsisterchromatidcohesion,istranscriptionallymisregulatedindifferenttypesofcarcinomas.Cellularstudies revealedthatbothMCMBPknockdownandoverexpressionindifferentbreastandcolorectalcelllinesisassociatedwith the emergence of a subpopulation of cells with abnormal nuclear morphology that likely arise as a consequence of aberrant cohesion events. Association analysis integrating gene expression data with clinical information revealed that enhanced MCMBP transcript levels correlate with an increased probability of relapse risk in colorectal cancers and different types of carcinomas. Moreover, a detailed study of a cohort of colorectal tumors showed that the MCMBP proteinaccumulatestohighlevelsincancercells,whereasinnormalproliferatingtissueitsabundanceislow,indicating that MCMBP could be exploited as a novel diagnostic marker for this type of carcinoma.
Ecoulement d'un fluide visqueux autour d'un disque en incidence frontale

Resume : Cette etude met en evidence, par la simulation numerique, les differents regimes hydrodynamiques de l’ecoulement autour d’un disque en incidence frontale, pour une gamme de nombres de Reynolds allant de 0 a 130. On confronte les champs de vitesse, de pression et de vorticite obtenus en ecoulement de Stokes avec les solutions theoriques. Pour des valeurs moderees du nombre de Reynolds, le sillage presente une zone de recirculation axisymetrique et stationnaire. A partir de Re 115, la symetrie axiale se brise au profit d’une symetrie plane . L’obstacle subit alors une force transverse et un couple non-nuls. L’instationnarite apparait pour Re 123 ou un nouveau regime hydrodynamique complexe se met en place.
altered intrinsic regional spontaneous brain activity in patients with optic neuritis: a resting-state functional magnetic resonance imaging study

Objective: To investigate the underlying regional homogeneity (ReHo) in brain-activity deficit in patients with optic neuritis (ON) and its relationship with behavioral performance. Materials and methods: In total, twelve patients with ON (four males and eight females) and twelve (four males and eight females) age-, sex-, and education-matched healthy controls underwent resting-state functional magnetic resonance imaging scans. The ReHo method was used to assess the local features of spontaneous brain activity. Correlation analysis was used to explore the relationship between the observed mean ReHo values of the different brain areas and the visual evoked potential (VEP) in patients with ON. Results: Compared with the healthy controls, patients with ON showed lower ReHo in the left cerebellum, posterior lobe, left middle temporal gyrus, right insula, right superior temporal gyrus, left middle frontal gyrus, bilateral anterior cingulate cortex, left superior frontal gyrus, right superior frontal gyrus, and right precentral gyrus, and higher ReHo in the cluster of the left fusiform gyrus and right inferior parietal lobule. Meanwhile, we found that the VEP amplitude of the right eye in patients with ON showed a positive correlation with the ReHo signal value of the left cerebellum posterior lobe ( r = 0.701, P = 0.011), the right superior frontal gyrus ( r = 0.731, P = 0.007), and the left fusiform gyrus ( r = 0.644, P = 0.024). We also found that the VEP latency of the right eye in ON showed a positive correlation with the ReHo signal value of the right insula ( r = 0.595, P = 0.041). Conclusion: ON may involve dysfunction in the default-mode network, which may reflect the underlying pathologic mechanism.
Late Quaternary environments of the Soviet Union

Bargaining with reading habit is no need. Reading is not kind of something sold that you can take or not. It is a thing that will change your life to life better. It is the thing that will give you many things around the world and this universe, in the real world and here after. As what will be given by this late quaternary environments of the soviet union, how can you bargain with the thing that has many benefits for you?
Shared Genetic Basis for Type 1 Diabetes, Islet Autoantibodies, and Autoantibodies Associated With Other Immune-Mediated Diseases in Families With Type 1 Diabetes

Type 1 diabetes (T1D) is a polygenic autoimmune disease that is often present with autoantibodies directed against pancreatic islet proteins. Many genetic susceptibility loci are shared with other autoimmune or immune-mediated diseases that also cosegregate in families with T1D. The aim of this study was to investigate whether susceptibility loci identified in genome-wide association studies (GWAS) of T1D were also associated with autoantibody positivity in individuals with diabetes. Fifty single nucleotide polymorphisms (SNPs) were genotyped in 6,556 multiethnic cases collected by the Type 1 Diabetes Genetics Consortium (T1DGC). These were tested for association with three islet autoantibodies—against autoantibodies to GAD (GADA), IA-2 (IA-2A), and zinc transporter 8 (ZnT8A)—and autoantibodies against thyroid peroxidase (TPOA) in autoimmune thyroid disease, gastric parietal cells (PCA) in autoimmune gastritis, transglutaminase (TGA) in celiac disease, and 21-hydroxylase (21-OHA) in autoimmune hypoadrenalism. In addition to the MHC region, we identify SNPs in five susceptibility loci (IFIH1, PTPN22, SH2B3, BACH2, and CTLA4) as significantly associated with more than one autoantibody at a false discovery rate less than 5%. IFIH1/2q24 demonstrated the most unrestricted association, as significant association was demonstrated for PCA, TPOA, GADA, 21-OHA, and IA-2A. In addition, 11 loci were significantly associated with a single autoantibody.
The Relationship between Musculoskeletal Pain and Demographic Variables in Nursing and Midwifery Students

Article Type Original study Authors Fereshteh Amini1*, PhD Fatteme Raiisi2, PhD How to cite this article Amini F, Raiisi F. , The Relationship between Musculoskeletal Pain and Demographic Variables in Nursing and Midwifery Students. 2019; 4(4): 256-262. 1 PhD Student of Health Education and Health Promotion Tarbiat Modares University 2 PhD Cognitive Science (IRCSS) Institute of Cognitive Science Study. Tehran, Iran.
Monitoring functional groups of herbivorous reef fishes as indicators of coral reef resilience : a practical guide for coral reef managers in the Asia Pacific region

Coral reefs are the most structurally complex and taxonomically diverse marine ecosystems on earth, providing ecosystem goods and services for millions of people worldwide. These reefs are seriously threatened by a variety of anthropogenic threats, particularly overexploitation of marine resources, destructive fishing practices and runoff from poor land use practices. Over half of the world’s reefs have already been lost or are under threat from these activities, with serious and widespread declines in reef health reported from around the world. Climate change also represents a new and increasing threat to coral reefs and associated ecosystems. Major threats include rising sea temperatures, rising sea levels and changes in ocean chemistry. Urgent action is now required to halt or reverse these threats and declines in coral reef health. One approach to the protection of reefs during this period of change is to manage for resilience.
Analyse théorique et expérimentale du rôle des paramètres de microstructure sur le comportement des composites a matrice fragile

Les composites a matrice ceramique renforcee par des fibres ceramiques longues et continues offrent des perspectives interessantes pour repondre a des besoins de l'industrie de realiser des pieces de hautes performances devant assurer avec fiabilite des fonctions thermo-structurales. Ils presentent des valeurs de tenacite et de resistance specifique interessantes, malgre la fragilite des constituants. Leur emploi pose le delicat probleme du dimensionnement des pieces et de leur fiabilisation. Us si cette recherche, basee sur une approche micro mecanique, tente- t-elle d'apporter des premiers elements de reponse quant au role des parametres de la microstructure sur le comportement de ces materiaux sous des sollicitations mecaniques simples a temperature ambiante. L'accent a ete mis sur le controle des parametres de l'elaboration de composites unidirectionnels SiC/verre LAS, ainsi que sur leurs caracterisations physico-chimiques, ou l'etat de cristallisation du verre et les phenomenes de diffusion d'elements a l'interface fibre-matrice ont pu etre identifies. Puis une methodologie experimentale de caracterisation micro mecanique des composites ceramiques a ete developpee. Elle se compose d'une analyse de l'interface fibre-matrice par la technique de micro indentation instrumentee. Elle a permis d'etablir des correlations entre la rigidite de l'interface et le comportement en flexion trois points des composites. La traction sous microscope optique, constituant la deuxieme experimentation, a permis d'identifier les phenomenes de rupture qui interviennent lors du chargement. L'interpretation des phenomenes de fissuration et l'etude de la sensibilite des parametres de la microstructure s'appuient sur des. Simulations numeriques qui integrent principalement la notion de glissement interfacial et les statistiques de rupture. Ces simulations sont relatives a des modeles pouvant decrire la fissuration multiple dans les composites mono filamentaires, et la propagation d'une fissure matricielle dans une plaque renforcee par des fibres.
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B cells acquire membrane-bound cognate antigens from the surface of the APCs by forming an IS, similar to that seen in T cells. Recognition of membrane-bound antigens on the APCs initiates adhesion of B lymphocytes to the antigen-tethered surface, which is followed by the formation of radial lamellipodia-like structures, a process known as B cell spreading. The spreading response requires the rearrangement of the submembrane actin cytoskeleton and is regulated mainly via signals transmitted by the BCR. Here, we show that cytoplasmic calcium is a regulator of actin cytoskeleton dynamics in B lymphocytes. We find that BCR-induced calcium mobilization is indispensible for adhesion and spreading of B cells and that PLC and CRAC-mediated calcium mobilization are critical regulators of these processes. Measuring calcium and actin dynamics in live cells, we found that a generation of actin-based membrane protrusion is strongly linked to the dynamics of a cytoplasmic-free calcium level. Finally, we demonstrate that PLC and CRAC channels regulate the activity of actin-severing protein cofilin, linking BCR-induced calcium signaling to the actin dynamics. J. Leukoc. Biol. 93: 000–000; 2013.
Clinical significance of serum total oxidant/ antioxidant status in patients with operable and advanced gastric cancer

Purpose: Oxidative stress was significantly associated with the development of malignancies. The purpose of this study was to evaluate the significance of serum total oxidant/antioxidant status in operable advanced gastric cancer patients. Materials and methods: A total of 284 patients who underwent curative resection for primary stage III gastric cancer were enrolled. Total oxidant status, total antioxidant status
Amniotic membrane extract and eye drops: a review of literature and clinical application

: The amniotic membrane (AM) has a long history of use in the treatment of various diseases of the ocular surface. It contains pluripotent cells, highly organized collagen, anti-fibrotic and anti-inflammatory cytokines, immune-modulators, growth factors, and matrix proteins. It is used to promote corneal healing in severely damaged eyes. Recently, AM extract and AM extract eye drops have been successfully used in clinical applications, including dry eye and chemical burns. We provide an overview on the recent progress in the preparation, mechanisms of action, and use of AM extract/AM extract eye drops for corneal and external eye diseases.
Tuberculous Uveitis: Distribution of Mycobacterium tuberculosis in the Retinal Pigment Epithelium

The diagnosis of intraocular tuberculosis has been a challenge until the introduction of polymerase chain reaction (PCR) to detect the mycobacterial-specific DNA sequence in the intraocular fluids. Such investigations have confirmed diverse manifestations of intraocular tuberculosis including retinal vasculitis and serpiginouslike choroiditis. The latter may manifest with multifocal lesions involving the inner choroid, which coalesce to form a geographic pattern simulating serpiginous choroiditis. Although, clinically, the choroiditis appears to involve primarily the inner choroid and retinal pigment epithelium (RPE), the presence of mycobacterium at these anatomic sites has not been documented. Herein, we describe a case of panuveitis that was clinically of unknown cause but for which histopathologic examination of the globe disclosed selective distribution of acid-fast organisms in the RPE. These were confirmed to be Mycobacterium tuberculosis by microdissection of the RPE, followed by real-time PCR.
Climate change effects in El Yunque National Forest, Puerto Rico, and the Caribbean region.

Understanding the current and expected future conditions of natural resources under a changing climate is essential to making informed management decisions. However, the ever-increasing volume of useful scientific information about climate change makes it difficult for managers and planners to effectively sort through and apply the emerging science. This report provides a knowledge base of peer-reviewed climate change science for El Yunque National Forest (also administratively designated as the Luquillo Experimental Forest), Puerto Rico, and the greater Caribbean region. We summarized scientific findings from over 240 peer-reviewed sources, covering a wide range of potential effects including changes to drivers and stressors and the effects of climate change on ecological, physical, social, and economic systems. Projected and observed changes include increases in air temperatures, an extension of the dry season, and changes in cloud cover that may lead to significant alterations to the diverse plant and animal communities of the Caribbean region. Species in cloud forests on isolated mountain peaks may be most at risk, due to sensitivities to moisture and a limited chance for migration. Changes in extreme weather patterns, including an increase in hurricane intensity and more frequent drought events, are projected to alter the distribution of tropical forest vegetation. Tourism patterns and recreational opportunities may change with an increase in extreme weather and impacts from sea level rise. The information presented in this report provides a starting point for natural resource managers, planners, and stakeholders to assess the vulnerability of local resources to climate change as part of a broader decision-making framework.
Use of Satellite Data and Farmers Eye Estimate for Crop Yield Modelling

Forecasting of crop production is one of the most important aspects of agricultural statistics system. Yield forecasts in the country at present are based on the traditional approach of crop condition and the area under the crop. The main factors affecting crop yield are agricultural inputs and weather. Use of these factors forms one class of models of forecasting crop yields. Another approach uses crop vigor through remotely sensed satellite data. In this regard several studies have been undertaken to establish relationship between spectral parameters through vegetation indices and the crop yield. Shah [12] used satellite data and geographical information system (GIS) technology for developing crop yield models. Verma et al. [22] presented a study on evaluation of crop cut method and farmers reports for estimating crop production. The results of the study showed that farmers eye estimates are remarkably close to actual production figures. In the present study an attempt is made to use farmers eye estimate of crop yield more objectively as an auxiliary variable along with the spectral vegetation indices obtained from satellite data to develop an improved crop yield model. The crop yield data is obtained from the general crop estimation surveys (GCES) based on crop cutting experiments. The farmer's eye estimates of the crop yield of the fields which have been selected for GCES and the satellite data of the corresponding area are obtained at the time of maximum vegetative growth stage of crop (about 4-6 weeks before harvest) when they have the highest correlation with the crop yield. The findings of this study suggest that a reliable and timely crop yield forecast may be obtained by using the NDVI from remote sensing satellite spectral data along with the farmer's eye estimate of yield as the two explanatory variables.
a triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells

: Trinucleotide CAG repeat expansion in the coding region of genes has a propensity to form polyglutamine (polyQ) aggregates that contribute to neuronal disorders. Strategies in elevating autophagy to disintegrate the insoluble aggregates without injuring cells have become a major goal for therapy. In this work, a triazole derivative, OC-13, was found accelerating autophagic clearance of polyQ aggregation in human neuroblastoma cells following induction of the enhanced green fluorescence-conjugated chimeric protein that enclosed 79 polyQ repeats (Q79-EGFP). OC-13 accelerated autophagy development and removed nuclear Q79-EGFP aggregates. The increase of Beclin-1, turnover of LC3-I to LC3-II and degradation of p62 supported autophagy activation. Pretreatment of autophagy inhibitor, bafilomycin A1, not only suppressed autophagolysome fusion, but also impeded aggregate eradication. The study also showed that c-Jun N-terminal kinase/Beclin-1 pathway was activated during OC-13 treatment and c-Jun N-terminal kinase inhibitor impaired autophagy and final breakdown. Autophagic clearance of the insoluble aggregates demonstrated the feasibility of OC-13 in alleviating neuronal disorders because of expanded glutamine stretches.
Effects of Fermented Soya Bean Supplements on Serum Insulin and Leptin Levels of High Fat Diet-induced Type 2 Diabetes Mellitus in Rabbits

Background : Increase in body fat and obesity are the main risk factors for type 2 diabetes mellitus which leads to several complications that affect many organs of the body when poorly controlled. Plant food sources rich in fibre and antioxidants play an important role in the management of diabetes mellitus. This study aimed to evaluate the effects of fermented soya bean supplements on serum insulin and leptin levels of high fat diet-induced type 2 diabetes mellitus in rabbits. Methods : Twenty rabbits of both sexes weighing, 1–2kg were used. Type 2 diabetes was induced by feeding the animals with a high fat diet for eight weeks. Blood glucose levels were determined after the induction period and rabbits having 130 mg/dL and above were selected for the study. The animals were grouped into four groups with five (n=5) rabbits in each group: Group 1 (diabetic control), received distilled water ad libitum for six weeks; Groups 2, 3 and 4 (diabetic rabbits) were fed with 12.5%, 25% and 50% fermented soya bean supplements respectively for a period of six weeks. Fasting blood glucose levels were determined at weekly interval during the treatment period. At the end of the experiment, the rabbits were euthanized by cervical dislocation and blood samples were collected for the determination of insulin, and leptin levels. Data obtained were analysed using ANOVA. Results : The result showed a significant decrease (P≤0.05) in leptin levels (ng/mL) in groups 2, 3 and 4 (11.30 ± 0.20, 9.20 ± 2.06 and 6.40 ± 1.36, respectively) as compared with the control (18.8 ± 1.59). Insulin levels were also decreased in all the treated groups when compared with the control, though not statistically significant, it may be biologically significant. Conclusion : The results of the study show that fermented soya bean supplementation possesses anti-diabetic properties and may help in the control of hyperleptinaemia
Identification of a system required for the functional surface localization of sugar binding proteins with class III signal peptides in Sulfolobus solfataricus

The hyperthermophilic archaeon Sulfolobus solfataricus contains an unusual large number of sugar binding proteins that are synthesized as precursors with a class III signal peptide. Such signal peptides are commonly used to direct archaeal flagellin subunits or bacterial (pseudo)pilins into extracellular macromolecular surface appendages. Likewise, S. solfataricus binding proteins have been suggested to assemble in higher ordered surface structures as well, tentatively termed the bindosome. Here we show that S. solfataricus contains a specific system that is needed for the functional surface localization of sugar binding proteins. This system, encoded by the bas (bindosome assembly system) operon, is composed of five proteins: basABC, three homologues of so‐called bacterial (pseudo)pilins; BasE, a cytoplasmic ATPase; and BasF, an integral membrane protein. Deletion of either the three (pseudo)pilin genes or the basEF genes resulted in a severe defect of the cells to grow on substrates which are transported by sugar binding proteins containing class III signal peptides, while growth on glucose and maltose was restored when the corresponding genes were reintroduced in these cells. Concomitantly, ΔbasABC and ΔbasEF cells were severely impaired in glucose uptake even though the sugar binding proteins were normally secreted across the cytoplasmic membrane. These data underline the hypothesis that the bas operon is involved in the functional localization of sugar binding proteins at the cell surface of S. solfataricus. In contrast to surface structure assembly systems of Gram‐negative bacteria, the bas operon seems to resemble an ancestral simplified form of these machineries.
Complete Genome Sequence of Bifidobacterium animalis subsp. lactis BLC1

ABSTRACT Bifidobacterium animalis subsp. lactis BLC1 is a probiotic bacterium that is widely exploited by food industries as the active ingredient of various functional foods. Here we report the complete genome sequence of B. animalis subsp. lactis BLC1, which is expected to provide insights into the biology of this health-promoting microorganism and improve our understanding of its phylogenetic relatedness with other members of the B. animalis subsp. lactis taxon.