Miracle-dz/UniFAR-FTUs huggingface dataset:
Fatores Incentivadores da Publicação de Guidance pelas Empresas do Ibovespa e sua Conformidade com o Pronunciamento de Orientação N° 04/2008 do CODIM Motivating Factors in Guidance Publications by Ibovespa Companies and Their Conformity to CODIM's Guideline Statement 04/2008

As the demand for resources in the national capital market grows, there is a stronger necessity by companies to release result prospects in order to keep or attract new investors. The guidance, a publication of future results, appears in this scenario as a response to this trend. In this perspective, the research investigates probable motivating factors in the publication of guidance by Ibovespa companies, while assessing their response to CODIM’s 04/2008 statement. The investigation comprehended factors related to institutional environments (listing segment at BM&FBovespa and listing of actions in foreign stock exchanges) and three groups of interest (suppliers, employees and investors). Qualitative in nature, this exploratory research has used the technique of content analysis. After analyzing the reference forms from 62 companies, it was possible to verify the disclosure of guidances, in 2010, of 26 of them, or 41.9% of the Ibovespa index. The results indicate that the factors analyzed were considered motivational in the evidencing of future result perspectives and the guidance publications, as recommended by the Institutional Theory and the Theory of Stakeholders. These results suggest that the surveyed companies provide information on future estimates to maintain or ensure its legitimacy in the market and towards its stakeholders. However, the content analysis showed that the guidance published by the companies do not meet in a satisfactory way the Statement 04/2008.
Dokumen Perancangan Perangkat Lunak Exam Management System (EMS) Institut Teknologi Telkom Purwokerto

Abstrak – Teknologi informasi dalam bidang pendidikan berkembang pesat secara eksponensial, hal tersebut dibuktikan oleh adanya berbagai macam e-learning. Learning Management System adalah suatu web belajar yang digunakan oleh mahasiswa maupun dosen untuk mengupload materi, menginput data nilai, merekap absensi mahasiswa, melihat jadwal mengajar. Pada masa pandemi, perguruan tinggi dituntut untuk melakukan seluruh kegiatan belajar mengajar secara daring. Penelitian ini bertujuan untuk menyusun dokumen EMS sebagai acuan dalam sistem ujian online yang terintegrasi tindakan untuk mengintegrasikan seluruh ujian online. Sistem manajemen ujian atau Exam Management System (EMS) adalah sebuah sistem untuk melaksanakan ujian yang digunakan oleh mahasiswa internal dan dapat juga digunakan oleh pihak akademik untuk menunjang pembelajaran secara online. EMS ini ditujukan untuk mengurangi kecurangan dalam pengerjaan soal ujian. EMS dapat membantu dosen dalam mengoreksi hasil ujian mahasiswa serta dapat mengetahui kecurangan saat ujian dikarenakan EMS diperlengkapi dengan fitur plagiarisme. Fitur ini hanya terdapat pada EMS dosen, yang berarti mahasiswa tidak dapat mengakses fitur plagiarism. Sistem ujian ini dibangun berbasiskan website dengan mengimplementasikan algoritma Fisher-Yates Shuffle dan algoritma Lavenshtein Distance. Kedua algoritma tersebut berfungsi untuk mengacak soal membandingkan jawaban pada saat pengoreksian, dan cek plagiarism. EMS dikembangkan dengan menganalisis dan merancang dokumen Deskripsi Perancangan Perangkat Lunak (DPPL). DPPL dijadikan dasar tahapan pengembangan dan implementasi sistem.
Health-related quality of life in edentulous patients

This study aimed to assess Oral Health-Related Quality of Life (OHQoL) and satisfaction in patients who had complete denture treatment and were diagnosed with systemic diseases. Eighty edentulous patients using new complete dentures were separated into four groups according to their diseases [diabetes mellitus (DM)/osteoporosis (OP)/hypertension (HP)/healthy (control)]. The groups answered the Turkish version of the United Kingdom-Oral Health-Related Quality of Life (OHQoL-UK) and Visual Analog Scale (VAS) questionnaire four weeks after treatment. OHQoL-UK scores were slightly higher for females regardless of the type of disease. Compared with the control participants (57.95±5.33), the scores of the OHQoL-UK were not significantly different in OP and HP groups except for the DM group (58.7±5.37, 58.9±6.44, 45.3±5.19 respectively). DM was significantly associated with the increase of OHQoL values (p<0.05). Patients in all groups reported significantly higher “physical health” scores than other subdomains of OHQoL-UK, although positive correlations were determined among them. Presence of disease had no relationship to the VAS scores. This study shows that systemic diseases might not affect and predict patients' satisfaction with their complete dentures and OHQoL. DM is an independent risk factor for oral health. Satisfaction with the prosthesis might concern a patient's level of OHQoL.
New Era of CPR: Application of I-Technology in Resuscitation

Introduction The present study evaluated the performance and acceptance of a cardiopulmonary resuscitation (CPR) feedback application for the iPhone (“PocketCPR®”) designed to improve chest compression performance. Methods We randomly assigned participants into two groups to perform chest compression with (study group) or without (control group) using the “PocketCPR®” on a manikin. The participants performed totally four sets of chest compression simulating two CPR scenarios. In the first scenario, no advanced airway was inserted while in the second scenario, advanced airway was inserted. We measured and compared the rate and depth of chest compression between the groups in both scenarios. Participants in study group also finished a questionnaire on the use of feedback application. Results The mean compression depth of the study group was significantly deeper both in the first scenario (5.22 cm; 4.56 cm, p=0.002; 5.30 cm; 4.56 cm, p=0.001) and the second scenario (5.34 cm; 4.56 cm, p<0.001; 5.35 cm; 4.49 cm, p<0.001). However, the mean compression rate of study group was significantly slower than the control group both in the first scenario (105.19; 118.58, p<0.001; 105.23; 119.36, p<0.001) and the second scenario (106.10; 121.08, p<0.001, 106.61; 117.42, p=0.002). Conclusion A mobile phone feedback application “PocketCPR®” improves chest compression quality by increasing the compression depth in laboratory setting. Further study is indicated to demonstrate its benefit in clinical setting.
Design of a Compact Wireless EEG Recorder With Extra-High Sampling Rate and Precise Time Synchronization for Auditory Brainstem Response

This paper proposed a compact wearable Electroencephalography (EEG) acquisition and analysis system targeting for event-related, wide-bandwidth biopotentials including Auditory Brainstem Response (ABR). The proposed system enables a 2-channel high EEG sampling mode with a sampling rate up to 16kHz, and an 8-channel low EEG sampling mode with a sampling rate of 4kHz. An audio codec is integrated generating synchronized audio stimulation and potential audio recording. A Bluetooth 5 based in-the-air protocol is designed featuring lossless neural data compression algorithm and lost-packet-retransmission strategy. Hydrogels are used as the tissue interface on the electrodes to improve the conductivity and stability. A precise time synchronization method with a standard deviation of $0.07\mu \text{s}$ is implemented for timestamping when external stimulus is requested. A Graphic User Interface (GUI) is developed for remote control of the proposed device as well as for real-time display of the acquired neural signal and analysis results. Both bench test and in-vivo click-ABRs test on human subject were performed on the proposed device. The experimental results proved the ability of the proposed EEG recorder to acquire high-time-resolution ABRs while giving periodic auditory stimulation.
METHODOLOGICAL REVIEW OF ANALYSES OF RURAL TRANSPORTATION IMPACTS IN DEVELOPING COUNTRIES

Studies of rural transportation impacts have been carried out over the last 20 years, with emphasis on the methodology and underlying models of causal relationships. The historical sequence of rural impact methodologies and the research on rural mobility and migration carried out in several countries during the last 10 years are examined. Particular emphasis is placed on the Kenya Rural Access Road Program research, Southeast Asian Research for SEATAC, and the Mexico Mobility Study. Present impact methodologies focus too narrowly on agricultural effects, despite early observations of wide-ranging impacts. They also fail to predict the significant increases in nonfarm traffic and related economic benefits that are signaled by the relatively high value placed on travel time demonstrated in the behavior of many rural travelers. This value reflects the importance of nonfarm employment and the benefits of increased mobility and service accessibility, which are crucial to adequate impact evaluation. A causal model of impacts is described, which defines the relationships between access change and rural socioeconomic development, including the role of intervening variables. Conclusions are drawn concerning the types of models that appear most promising for future impact analysis.
Machine learning activation energies of chemical reactions

Application of machine learning (ML) to the prediction of reaction activation barriers is a new and exciting field for these algorithms. The works covered here are specifically those in which ML is trained to predict the activation energies of homogeneous chemical reactions, where the activation energy is given by the energy difference between the reactants and transition state of a reaction. Particular attention is paid to works that have applied ML to directly predict reaction activation energies, the limitations that may be found in these studies, and where comparisons of different types of chemical features for ML models have been made. Also explored are models that have been able to obtain high predictive accuracies, but with reduced datasets, using the Gaussian process regression ML model. In these studies, the chemical reactions for which activation barriers are modeled include those involving small organic molecules, aromatic rings, and organometallic catalysts. Also provided are brief explanations of some of the most popular types of ML models used in chemistry, as a beginner's guide for those unfamiliar.
Influence of Leachate Matrix on Oxidation Performance of Ozonation and AOPs

Landfill leachate is a critical environmental issue that should be adequately treated to prevent it from spreading to the environment. This study explored the influence of raw leachate matrix and treated leachate matrix on O3, O3/H2O2, and O3/PS performance. O3 and AOPs were conducted in a laboratory-scale batch reactor. The findings showed the degradation of p-cresol, COD, and humic substances was much slower in treated leachate matrix than in raw leachate matrix. However, color was found easier to remove in treated leachate. The results revealed a synergic effect between molecular O3 and dissolved organic matter in the raw leachate as the O3 performance was enhanced in the presence of raw leachate matrix, except for color removal. The highest degradation of more than 90% was achieved in O3/H2O2 to remove COD, p-cresol, and humic substances, although it is the most affected by the leachate matrix. This study provides vital insight into the notable performance of O3/PS in color removal regardless of the influence of leachate matrix, suggesting that the sulfate radical-induced oxidation outperformed O3 and O3/H2O2 in reducing nitrogen-containing compounds.
Quantifying function in the zebrafish embryonic heart: A study on the role of timed mechanical cues

ii ACKNOWLEDGEMENTS . iv TABLE OF CONTENTS . vi LIST OF FIGURES . xi CHAPTER 1: HYPOTHESIS AND AIMS . 1 1.1 Chapter Introduction . 1 1.2 Aim 1 . 2 1.3 Aim 2 . 2 1.4 Aim 3 . 3 1.5 Overview of Results . 4 1.6 Dissertation Organization . 5 CHAPTER 2: LITERATURE REVIEW . 6 2.1 Congenital Heart Defect Statistics . 6 2.2 Epigenetics . 6 2.3 Animal Models in Heart Development Research . 7 2.4 Early Heart Development in the Zebrafish . 10 2.5 Pumping Mechanics of the Embryonic Heart . 13 2.6 Mechanical Stress and Fluid Dynamics in the Embryonic Heart . 16 2.7 Cellular Response to Mechanical Stress . 21 2.8 Effect of Blood Flow on Heart Development . 24
Clohesyomyces symbioticus sp. nov., a fungal endophyte associated with roots of water smartweed (Persicaria amphibia)

The widespread aquatic plant Persicaria amphibia (water smartweed, Polygonaceae) occurs in both flooded aquatic habitats and moist terrestrial environments. Its physiological versatility and wide geographic range highlight its resilience to stress and make the species intriguing for the study of fungal endophytes. Endophytes occur within living plant tissues and are known from diverse aquatic, marine, and terrestrial plants, where they often mitigate plant responses to stress. As part of a study evaluating endophyte communities associated with aquatic plants in lentic waters of Arizona, USA, we isolated a distinctive clade of endophytes from healthy, living roots of seasonally inundated P. amphibia, which we describe here on the basis of morphology and evidence from four loci as new species Clohesyomyces symbioticus (Lindgomycetaceae, Pleosporales, Dothideomycetes, Ascomycota). Clohesyomyces has long been considered a monotypic genus comprising the saprobic species C. aquaticus, presently known from submerged wood in freshwater systems in Asia and Australia. Description of Clohesyomyces symbioticus highlights the occurrence of endophytism in this genus and expands its geographic scope to the western hemisphere.
Von Willebrand factor and esophageal varices in children with chronic liver diseases

Aim of the study To evaluate the role of plasma level of von Willebrand factor antigen (vWF-Ag) as a possible predictor for the presence of esophageal varices (EVs) in children with chronic liver diseases (CLDs). Material and methods All patients underwent upper esophagogastroduodenoscopy (EGD) and were categorized as group I (had EVs) and group II (had no EVs). The following patient data were determined: Child-Pugh score (CPS), plasma vWF-Ag, vWF-Ag/thrombocyte ratio (VITRO) score, aspartate transaminase (AST) to platelet ratio index (APRI) score, AST/alanine transaminase (ALT), platelet count/spleen diameter, grading of EVs (small, medium and large) and categorizing the stage of liver fibrosis. Results The analysis included 50 patients with CLD; 30 (60%) were female. The commonest etiological diagnoses were autoimmune hepatitis (AIH) (20%) and extra-hepatic biliary atresia (EHBA) (12%). 26% of cases were categorized as undiagnosed CLD. The CPS showed CPS-A 34%, CPS-B 44% and CPS-C 22%. The vWF-Ag was found at a high level of 243.52 ±195.97, with a highly statistically significant difference in discriminating the EVs with 74% accuracy at a cut-off value of 108.99 IU/ml, p < 0.0001. Also, ROC analysis was performed for discriminating large esophageal varices with 84% accuracy at a cut-off value of 475.85 mg%. The VITRO score at a cut-off value of 1.72 could detect EVs with 70% sensitivity, 86.7% specificity, and 80% accuracy. Conclusions High vWF-Ag is a valuable prognostic tool for estimating the presence of EVs, and higher vWF-Ag is associated with increased grade of EVs.
The Emerging Role of MicroRNAs in Bone Diseases and Their Therapeutic Potential

MicroRNAs (miRNAs) are a class of small (20–24 nucleotides), highly conserved, non-coding RNA molecules whose main function is the post-transcriptional regulation of gene expression through sequence-specific manners, such as mRNA degradation or translational repression. Since these key regulatory molecules are implicated in several biological processes, their altered expression affects the preservation of cellular homeostasis and leads to the development of a wide range of pathologies. Over the last few years, relevant investigations have elucidated that miRNAs participate in different stages of bone growth and development. Moreover, the abnormal expression of these RNA molecules in bone cells and tissues has been significantly associated with the progression of numerous bone diseases, including osteoporosis, osteosarcoma, osteonecrosis and bone metastasis, among others. In fact, miRNAs regulate multiple pathological mechanisms, including altering either osteogenic or osteoblast differentiation, metastasis, osteosarcoma cell proliferation, and bone loss. Therefore, in this present review, aiming to impulse the research arena of the biological implications of miRNA transcriptome in bone diseases and to explore their potentiality as a theragnostic target, we summarize the recent findings associated with the clinical significance of miRNAs in these ailments.
A review of durian plant-bat pollinator interactions

ABSTRACT Durian (Durio zibethinus) brings in princely revenue for the fruit economy in Southeast Asia, ushering the current trend of clearing forests for durian plantations. Despite the thorny fruit’s popularity and increasing bat-durian papers, not many associate their vital plant-pollinator relationship. This unfamiliarity has led to the persisting negative connotations of bats as agricultural pests and worse, a disease carrier amplified by the Covid-19 pandemic. This review focuses on the bat-durian relationship comprising botanical insights and pollination ecology in relevance to the wider pteropodid-plant interactions. The majority of the studies compiled have concluded that bats are the most effective pollinator for durian than insects. Six fruit bat species (Chiroptera: Pteropodidae) have been recorded pollinating durian flowers, with several other pteropodid species speculated to pollinate durian, including in non-native countries. Lastly, we address the research gaps for the bat-durian relationship, which can also be applied to other chiropterophilous plants.
Interactions of nutrient and water availability control growth and diversity effects in a Salix two‐species mixture

Plant growth is constrained by resource availability and interactions among limiting resources—abundance in one resource (e.g., nutrients) might promote growth, thereby causing the depletion of other resources (e.g., water), potentially inducing stress or mortality. In a diverse plant community, complementary resource use has been hypothesized to increase the overall productivity, but how diversity effects vary with interacting water and nutrient limitation and through time is not known. Here, we address this knowledge gap in a controlled pot experiment where species composition (two Salix species in monoculture or mixture), nutrient addition, and watering frequency (for fixed total water inputs) were varied during two growing seasons. High nutrient availability promoted plant growth and nitrogen accumulation at the pot scale, as well as increased allocation aboveground, but also triggered more intense water stress and mortality, as larger plants depleted soil water during warm periods. Supplying water more frequently slightly alleviated water stress under high nutrient availability, thus promoting growth and nitrogen accumulation. The species mixtures performed better than the average of the mixture constituents (positive net diversity effects) and increasingly so through time. The complementarity and selection effects, respectively, increased and decreased under both high nutrient availability and high watering frequency. Overall, these results suggest that as plants grow larger, plant interactions and resource partitioning intensify, causing the positive diversity effects, but also that drought consequences might be exacerbated in plant communities rapidly growing thanks to high nutrient supply.
Blackberry phenolic and volatile extracts inhibit cytokine secretion in LPS-inflamed RAW264.7 cells

The anti-inflammatory activity of blackberries has been attributed to phenolic compounds, especially anthocyanins. The present study hypothesized that volatiles could contribute to anti-inflammatory activity as well. The anti-inflammatory properties of three blackberry genotypes varying in total volatile and phenolic contents were assessed by measuring concentrations of nitric oxide (NO), interleukin-6 (IL-6) and tumor necrosis factor -α (TNF-α) within LPS-inflamed RAW264.7 murine macrophage cells after a preventive treatment of either a phenolic or a volatile extract. Extracts from blackberry genotypes A2528T, A2587T and Natchez had total phenolic contents of 4315, 3369 and 3680 µg/mL, respectively, and total volatile contents of 283, 852 and 444 ng/mL, respectively. Phenolic and volatile extracts of all genotypes significantly lowered the secretion of NO, IL-6 and TNF-α in ranges varying between 20-42%, 34-60% and 28-73% inhibition, respectively. Volatile extracts exhibited greater anti-inflammatory properties than phenolic extracts, despite being present at much lower concentrations in the berries. Further research is needed to assess bioavailability and anti-inflammatory effect of blackberry volatiles in vivo.
Tanshinone I Mitigates Steroid-Induced Osteonecrosis of the Femoral Head and Activates the Nrf2 Signaling Pathway in Rats

Steroid-induced osteonecrosis of the femoral head (SIONFH) is a frequent orthopedic disease caused by long-term or high-dose administration of corticosteroids. Tanshinone I (TsI), a flavonoid compound isolated from Salvia miltiorrhiza Bunge, has been reported to inhibit osteoclastic differentiation in vitro. This study aimed to investigate whether TsI can ameliorate SIONFH. Herein, SIONFH was induced by intraperitoneal injection of 20 μg/kg lipopolysaccharide every 24 h for 2 days, followed by an intramuscular injection of 40 mg/kg methylprednisolone every 24 h for 3 days. Four weeks after the final injection of methylprednisolone, the rats were intraperitoneally administrated with low-dose (5 mg/kg) and high-dose (10 mg/kg) TsI once daily for 4 weeks. Results showed that TsI significantly alleviated osteonecrotic lesions of the femoral heads as determined by micro-CT analysis. Furthermore, TsI increased alkaline phosphatase activity and expressions of osteoblastic markers including osteocalcin, type I collagen, osteopontin, and Runt-related transcription factor 2 and decreased tartrate-resistant acid phosphatase activity and expressions of osteoclastic markers including cathepsin K and acid phosphatase 5. TsI also reduced inflammatory response and oxidative stress and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway in the femoral heads. Taken together, our findings show that TsI can relieve SIONFH, indicating that it may be a candidate for preventing SIONFH.