Miracle-dz/UniFAR-FTUs huggingface dataset:
Association Between Waist Circumference and the Prevalence of (Pre) Hypertension Among 27,894 US Adults

Aims: This study aimed to investigate the association between waist circumference and the prevalence of (pre) hypertension. Methods: Cross-sectional data from the 2007–2018 National Health and Nutrition Examination Survey were analyzed. The historical trend of abdominal obesity was assessed by the Cochran–Armitage trend test. After preprocessed by the multiple imputation strategy, we used generalized additive models to assess the association of waist circumference with systolic/diastolic blood pressure and performed correlation analysis by the Spearman correlation coefficient. Moreover, we used multivariable logistic regression (non-adjusted, minimally adjusted, and fully adjusted models), restricted cubic spline, and sensitivity analysis to investigate the association between waist circumference and (pre) hypertension. Results: A total of 27,894 participants were included in this study. In the fully adjusted model, waist circumference was positively associated with (pre) hypertension with odds ratios (95% confidence intervals) of 1.28 (1.18–1.40) in the young group and 1.23 (1.15–1.33) in the old group. Restricted cubic spline showed a higher prevalence of (pre) hypertension with the increase of waist circumference. In the subgroup analysis, waist circumference showed a robust trend across all BMI categories with odds ratios (95% confidence intervals) of 3.33 (1.29–8.85), 1.35 (1.17–1.57), 1.27 (1.13–1.41), and 1.09 (1.01–1.17) in underweight, normal weight, overweight, and obese individuals, respectively. Conclusion: This study highlighted waist circumference as a significant biomarker to evaluate the risk of (pre) hypertension. Our results supported the measure of waist circumference regardless of BMI when evaluating the cardiometabolic risk related to fat distribution.
Species Distribution Models of the Spartina alterniflora Loisel in Its Origin and Invasive Country Reveal an Ecological Niche Shift

Spartina alterniflora is a perennial herb native to the American Atlantic coast and is the dominant plant in coastal intertidal wetlands. Since its introduction to China in 1979, it has quickly spread along the coast and has caused various hazards. To control the further spread of S. alterniflora in China, we first reconstructed the history of the spread of S. alterniflora in its invasion and origin countries. We found that S. alterniflora spreads from the central coast to both sides of the coast in China, while it spreads from the west coast to the east coast in America. Furthermore, by comparing 19 environmental variables of S. alterniflora in its invasion and origin countries, it was found that S. alterniflora is more and more adaptable to the high temperature and dry environment in the invasion country. Finally, we predicted the suitable areas for this species in China and America using the maximum entropy (MaxEnt) model and ArcGIS. Overall, through analysis on the dynamic and trend of environmental characteristics during the invasion of S. alterniflora and predicting its suitable area in the invasion area, it guides preventing its reintroduction and preventing its further spread of the species has been found. It has reference significance for studying other similar alien plants and essential enlightening relevance to its invasion and spread in similar areas.
On the Use of Heterogeneous Stock Mice to Map Transcriptomes Associated With Excessive Ethanol Consumption

We and many others have noted the advantages of using heterogeneous (HS) animals to map genes and gene networks associated with both behavioral and non-behavioral phenotypes. Importantly, genetically complex Mus musculus crosses provide substantially increased resolution to examine old and new relationships between gene expression and behavior. Here we report on data obtained from two HS populations: the HS/NPT derived from eight inbred laboratory mouse strains and the HS-CC derived from the eight collaborative cross inbred mouse strains that includes three wild-derived strains. Our work has focused on the genes and gene networks associated with risk for excessive ethanol consumption, individual variation in ethanol consumption and the consequences, including escalation, of long-term ethanol consumption. Background data on the development of HS mice is provided, including advantages for the detection of expression quantitative trait loci. Examples are also provided of using HS animals to probe the genes associated with ethanol preference and binge ethanol consumption.
The Impact of Gut Microbiota on Post-Stroke Management

According to the recent Global Burden of Disease (GBD) study, stroke is the leading cause of death and disability, particularly in aged population (Collaborators, 2019). In the last decades, the mortality rate of stroke has significantly decreased, and the disability-adjusted life year (DALY) and years lived with disability (YLD) have been controlled (Collaborators, 2019). Nevertheless, stroke remains as a major health concern in both developed and developing countries (Collaborators, 2019). Novel therapeutic methods and improved management in stroke prevention and post-stroke recovery are still urgently demanded. In a long period, most studies focused on the cardiovascular and neurological aspects of stroke, while only a small group of researchers kept an eye on the pathological alterations in gastrointestinal tract of stroke patients (Schaller et al., 2006). These studies mainly discussed the consequences of impaired nutritional status in stroke events (Schaller et al., 2006). Notably, in the past ten years, the ecosystem of microbiota in gastrointestinal tract has been linked to various physiological and pathological processes (Donaldson et al., 2016). Increasing evidences have demonstrated that the compositional changes of gut microbiota complexity are involved in diverse gastrointestinal disorders (Manichanh et al., 2006) and metabolic dysfunctions such as obesity and diabetes (Wen et al., 2008; Ridaura et al., 2013), which may also contribute to the nutrition status after stroke. Moreover, gut microbiota is recently considered to communicate with central nervous system in a bidirectional pattern (Collins et al., 2012). The metabolic products of gut microbiota regulate not only normal brain development but also various brain disorders through neural, immunological, endocrinal and metabolic pathways (Collins et al., 2012). Therefore, deep insights into the relationship between gut microbiota and stroke could provide novel avenues to improve post-stroke recovery and prevent stroke recurrence. More than 85% of stroke events are caused by the blockage of blood flow, namely ischemic stroke (Moskowitz et al., 2010), thus we focused on ischemic stroke in this review. We summarized recent advances in the interactions between commensal gut microbiota and ischemic stroke: how stroke insult changes gut microbiota composition and how these shifts reversely influence stroke outcome and prognosis. We also attempted to figure out the clues from latest literatures by which gut microbiota may affect the major aspects during post-stroke management, including the controls of body temperature, blood glucose, blood pressure, oxygen and hydration (Bhalla et al., 2001). The concerns on gut microbiota will provide researchers novel therapeutic potentials for ischemic stroke and remind clinicians for special cares in post-stroke management.
Gut and Brain: Investigating Physiological and Pathological Interactions Between Microbiota and Brain to Gain New Therapeutic Avenues for Brain Diseases

Brain physiological functions or pathological dysfunctions do surely depend on the activity of both neuronal and non-neuronal populations. Nevertheless, over the last decades, compelling and fast accumulating evidence showed that the brain is not alone. Indeed, the so-called “gut brain,” composed of the microbial populations living in the gut, forms a symbiotic superorganism weighing as the human brain and strongly communicating with the latter via the gut–brain axis. The gut brain does exert a control on brain (dys)functions and it will eventually become a promising valuable therapeutic target for a number of brain pathologies. In the present review, we will first describe the role of gut microbiota in normal brain physiology from neurodevelopment till adulthood, and thereafter we will discuss evidence from the literature showing how gut microbiota alterations are a signature in a number of brain pathologies ranging from neurodevelopmental to neurodegenerative disorders, and how pre/probiotic supplement interventions aimed to correct the altered dysbiosis in pathological conditions may represent a valuable future therapeutic strategy.
Oil removal from crude oil-in-saline water emulsions using chitosan as biosorbent

ABSTRACT The sorption of oil from crude oil-in-saline water emulsions was studied using chitosan as biosorbent. The main parameters investigated were chitosan dosage, contact time, and initial crude oil concentration at fixed initial pH. The results showed that the sorption equilibrium was reached within 120 min at oil content as low as 20 mg L−1. Sorption depends on initial oil concentration and sorbent dosage and may reach up to 95% efficiency in the most favorable conditions. The residual oil concentrations obtained after sorption were always beneath the official limit of oil discharge into environment.
The Cytopathic Effect of Different Toxin Concentrations From Different Clostridioides difficile Sequence Types Strains in Vero Cells

Clostridioides difficile is one of the leading causes of healthcare-associated diarrhea, with severity ranging from mild, self-limiting disease, to life-threatening toxic megacolon. C. difficile infection (CDI) pathogenesis is mediated by the TcdA and TcdB toxins. This work aimed to draw correlations between toxin levels, bacterial strains, and disease severity in 63 CDI patients. C. difficile typing was performed by multi-locus sequence types (MLST). Toxin concentrations were measured using the TOX A/B test. In addition, cell cytotoxicity assay was performed following Vero cell exposure to stool extracts (24 h). The most prevalent sequence types (ST) were ST2, ST4, ST6, ST13, ST37, ST42, and ST104, with highest toxin levels produced by ST42 and ST104 (302.5 and 297.1 ng/ml, respectively). These strains had a stronger cytopathic effect (CPE) on Vero cells as compared to strains with lower toxin concentrations (p < 0.001), as manifested by lower cell counts and higher percentages of cell rounding and adhesion loss. Although no association was found between ST, toxin concentrations, and disease severity, a diverse in vitro effect of different STs on the viability and activity of Vero cells was observed. These findings suggest that disease severity is affected by both host immune responses and by bacterial characteristics.
Impact of Climate Change on Water Availability in Water Source Areas of the South-to-North Water Diversion Project in China

The South-to-North Water Diversion project (SNWD project) is a mega water project designed to help solve water shortages in North China. The project’s management and operation are highly influenced by runoff change induced by climate change in the water source areas. It is important to understand water availability from the source areas in the context of global warming to optimize the project’s regulation. Based on the projections of nine GCMs, the future runoff in the water source areas of the three diversion routes was simulated by using a grid-based model RCCC-WBM (Water Balance Model developed by Research Center for Climate Change). Results show that temperature will rise by about 1.5°C in the near future (2035, defined as 2026–2045) and 2.0°C in the far future (2050, defined as 2041–2060) relative to the baseline period of 1956–2000. Although GCM projections of precipitation are highly uncertain, the projected precipitation will likely increase for all three water source areas. As a result of climate change, the simulated runoff in the water source areas of the SNWD project will likely increase slightly by less than 3% relative to the baseline period for the near and far future. However, due to the large dispersion and uncertainty of GCM projections, a high degree of attention should be paid to the climate-induced risk of water supply under extreme situations, particularly for the middle route of the SNWD project.
Fiber Rearrangement and Matrix Compression in Soft Tissues: Multiscale Hypoelasticity and Application to Tendon

It is widely accepted that the nonlinear macroscopic mechanical behavior of soft tissue is governed by fiber straightening and re-orientation. Here, we provide a quantitative assessment of this phenomenon, by means of a continuum micromechanics approach. Given the negligibly small bending stiffness of crimped fibers, the latter are represented through a number of hypoelastic straight fiber phases with different orientations, being embedded into a hypoelastic matrix phase. The corresponding representative volume element (RVE) hosting these phases is subjected to “macroscopic” strain rates, which are downscaled to fiber and matrix strain rates on the one hand, and to fiber spins on the other hand. This gives quantitative access to the fiber decrimping (or straightening) phenomenon under non-affine conditions, i.e. in the case where the fiber orientations cannot be simply linked to the macroscopic strain state. In the case of tendinous tissue, such an RVE relates to the fascicle material with 50 μm characteristic length, made up of crimped collagen bundles and a gel-type matrix in-between. The fascicles themselves act as parallel fibers in a similar matrix at the scale of a tissue-related RVE with 500 μm characteristic length. As evidenced by a sensitivity analysis and confirmed by various mechanical tests, it is the initial crimping angle which drives both the degree of straightening and the shape of the macroscopic stress-strain curve, while the final linear portion of this curve depends almost exclusively on the collagen bundle elasticity. Our model also reveals the mechanical cooperation of the tissue’s key microstructural components: while the fibers carry tensile forces, the matrices undergo hydrostatic pressure.
Assessment of Myocardial Function During Blood Pressure Manipulations Using Feature Tracking Cardiovascular Magnetic Resonance

Background: Coronary autoregulation is a feedback system, which maintains near-constant myocardial blood flow over a range of mean arterial pressure (MAP). Yet in emergency or peri-operative situations, hypotensive or hypertensive episodes may quickly arise. It is not yet established how rapid blood pressure changes outside of the autoregulation zone (ARZ) impact left (LV) and right ventricular (RV) function. Using cardiovascular magnetic resonance (CMR) imaging, measurements of myocardial tissue oxygenation and ventricular systolic and diastolic function can comprehensively assess the heart throughout a range of changing blood pressures. Design and methods: In 10 anesthetized swine, MAP was varied in steps of 10–15 mmHg from 29 to 196 mmHg using phenylephrine and urapidil inside a 3-Tesla MRI scanner. At each MAP level, oxygenation-sensitive (OS) cine images along with arterial and coronary sinus blood gas samples were obtained and blood flow was measured from a surgically implanted flow probe on the left anterior descending coronary artery. Using CMR feature tracking-software, LV and RV circumferential systolic and diastolic strain parameters were measured from the myocardial oxygenation cines. Results: LV and RV peak strain are compromised both below the lower limit (LV: Δ1.2 ± 0.4%, RV: Δ4.4 ± 1.2%, p < 0.001) and above the upper limit (LV: Δ2.1 ± 0.4, RV: Δ5.4 ± 1.4, p < 0.001) of the ARZ in comparison to a baseline of 70 mmHg. LV strain demonstrates a non-linear relationship with invasive and non-invasive measures of oxygenation. Specifically for the LV at hypotensive levels below the ARZ, systolic dysfunction is related to myocardial deoxygenation (β = −0.216, p = 0.036) in OS-CMR and both systolic and diastolic dysfunction are linked to reduced coronary blood flow (peak strain: β = −0.028, p = 0.047, early diastolic strain rate: β = 0.026, p = 0.002). These relationships were not observed at hypertensive levels. Conclusion: In an animal model, biventricular function is compromised outside the coronary autoregulatory zone. Dysfunction at pressures below the lower limit is likely caused by insufficient blood flow and tissue deoxygenation. Conversely, hypertension-induced systolic and diastolic dysfunction points to high afterload as a cause. These findings from an experimental model are translatable to the clinical peri-operative environment in which myocardial deformation may have the potential to guide blood pressure management, in particular at varying individual autoregulation thresholds.
1-MNA Ameliorates High Fat Diet-Induced Heart Injury by Upregulating Nrf2 Expression and Inhibiting NF-κB in vivo and in vitro

High levels of free fatty acids (FFA) are closely associated with obesity and the development of cardiovascular diseases. Recently, nicotinamide adenine dinucleotide (NAD) metabolism has emerged as a potential target for several modern diseases including diabetes. Herein, we explored the underlying mechanisms of NAD metabolism associated with the risk of cardiovascular disease. Our study found that nicotinamide N-methyltransferase (NNMT) mRNA levels were significantly increased in the hearts of FFA-bound-albumin-overloaded mice and in H9C2 cells treated with palmitic acid (PA). We studied the mechanisms underlining the anti-inflammatory and anti-oxidant activities of 1-methylnicotinamide (1-MNA), a metabolite of NNMT. We found a significantly higher level of reactive oxygen species, inflammation, apoptosis, and cell hypertrophy in PA-treated H9C2 cells and this effect was inhibited by 1-MNA treatment. in vivo, 1-MNA improved inflammation, apoptosis, and fibrosis damage in mice and this inhibition was associated with inhibited NF-κB activity. In conclusion, our study revealed that 1-MNA may prevent high fatty diet and PA-induced heart injury by regulating Nrf2 and NF-κB pathways.
A Novel Monocyte Subset as a Unique Signature of Atherosclerotic Plaque Rupture

The evaluation of monocyte subset distribution among acute coronary syndrome (ACS) patients according to culprit coronary plaque morphology has never been explored. We evaluated whether there were significant differences in frequency of circulating monocyte subsets isolated from ACS patients according to optical coherence tomography (OCT) investigation of plaque erosion and rupture. We enrolled 74 patients with non-ST-elevation ACS (NSTE-ACS), 21 of them underwent OCT investigation of the culprit coronary plaque and local macrophage infiltration (MØI) assessment. As control, we enrolled 30 chronic coronary syndrome (CCS) patients. We assessed the frequency of monocyte subsets in the whole study population, in reliance on their CD14 and CD16 expression (classical, CM: CD14++CD16–; intermediates, IM: CD14++CD16+; non-classical, NCM: CD14+CD16++). Then, we tested the effect of lipopolysaccharide (LPS) (a CD14 ligand) on peripheral blood mononuclear cells (PBMCs) of NSTE-ACS patients, quantifying the inflammatory cytokine levels in cell-culture supernatants. Our data proved that monocyte subsets isolated from NSTE-ACS patients represent a peculiar biological signature of the pathophysiological mechanism lying beneath atherosclerotic plaque with a ruptured fibrous cap (RFC) as compared with plaque erosion. Moreover, the magnitude of LPS-mediated effects on IL-1β, IL-6, and IL-10 cytokine release in cell-culture supernatants appeared to be greater in NSTE-ACS patients with RFC. Finally, we described a fourth monocyte population never explored before in this clinical setting (pre-classical monocytes, PCM: CD14+CD16–) that was prevalent in NSTE-ACS patients as compared with CCS and, especially, in patients with RFC and culprit plaque with MØI.
A Review of Microalgal Biofilm Technologies: Definition, Applications, Settings and Analysis

Biofilm-based algal cultivation has many advantages over the conventional suspended growth methods and has received increased attention as a potential platform for algal production, wastewater treatment (nutrient removal), and a potential pathway to supply feedstock for microalgae-based biorefinery attempts. However, the attached cultivation by definition and application is a result of a complex interaction between the biotic and abiotic components involved. Therefore, the entire understanding of the biofilm nature is still a research challenge due to the need for real-time analysis of the system. In this review, the state of the art of biofilm definition, its life cycle, the proposed designs of bioreactors, screening of carrier materials, and non-destructive techniques for the study of biofilm formation and performance are summarized. Perspectives for future research needs are also discussed to provide a primary reference for the further development of microalgal biofilm systems.
REMOVAL OF PENTACHLOROPHENOL FROM AQUEOUS SOLUTIONS BY ADSORPTION ON DATE-PITS AVTIVATED CARBON

Adsorbable organic halide (AOX) compounds known with their toxic effect, produced as by-product for drinking water disinfection. The present work studied the removal of pentachlorophenol (PCP) as a model AOX compound in water. The use of a locally prepared date-pit activated carbon (DPAC) as adsorbent of pentachlorophenol from aqueous solutions was examined over pH range (2-11) and at different temperatures 25, 35, 45 and 55 ̊C. Langmuir, Frendulich, Temkin and Redlich-Peterson isotherm models were tested for modeling the adsorption isotherm at equilibrium. date-pit activated carbon examined by Elemental Analysis and FTIR.
Synthesis of a Trivalent
 P
 ‐Chloro‐Dithienophosphole and Its Reactivity with Organometallic Reagents

: P -chloro-dithieno[3,2-b :2’,3’-d ]phosphole was synthesized and isolated from the reaction of an aminophosphole and HCl. Developed to act as a common starting material for P -functionalized phospholes, the compound exhibits a surprising reactivity by generating dimeric biphospholes. Despite this apparent sensitivity, when reacting with organolithium and Grignard reagents, a series of differently P -functionalized dithieno[3,2-b :2’,3’-d ]phospholes was accessible. Unexpectedly, organolithium reagents showed reduced reactivity with the chlorophosphole, limiting yields of the desired products due to the competing dimerization. Nonetheless, P - functionalized phospholes were isolated from reactions of the title compound with both Grignard and organolithium reagents in yields equivalent to, or higher, than by previous methods. A bithiophene-bridged bisphosphole system was also successfully synthesized without the necessity of generating a bis(dichlorophosphino) reagent. Finally, the isolated P -functionalized phospholes were analyzed for their photophysical properties. In general, these compounds are strong absorbers in the UV/visible range of the optical spectrum. The phospholes’ emissions were consistent with several previously reported, however, with low quantum yields.