Miracle-dz/UniFAR-FTUs huggingface dataset:
The effects of family environment cognition and its difference perceived by adolescents and their parents on the treatment effect of non-suicidal self-injury behaviors in adolescents: a 1-year prospective cohort study

Introduction Family environment is the primary environment for adolescent growth and development, which is believed to have an important impact on the occurrence of non-suicidal self-injury (NSSI) behavior in adolescents. This study aimed to explore the effects of family environment cognition and cognitive differences perceived by adolescents and their parents on the treatment effects of NSSI in adolescents and to provide more potential perspectives for NSSI treatment. Methods A one-year prospective longitudinal sub-cohort investigation was carried out among 199 adolescents engaged in NSSI and one of their important guardians from the Longitudinal Psychosomatic Disease Study (LoPDS). The NSSI behaviors of adolescents were evaluated at 3 months, 6 months and 1 year after enrollment. The family environment scale (FES) and NSSI Behavior Questionnaire were used as assessment tools for family environment and adolescents NSSI behaviors. Multiple linear regression was used to investigate the role of family environment perception difference in the treatment effect of adolescent NSSI. Results After one year of follow-up, the perceived self-injury impulse score in recent 2 weeks, self-injury impulse frequency in recent 2 weeks, total number of self-injury in recent 2 weeks decreased significantly. The higher the adolescent family cohesion (Beta: 1.130, 95% CI: 0.886,1.373; p=0.032), parental family expressiveness (Beta: 0.818, 95% CI: 0.375,1.260; p=0.037) and parental family active-recreational orientation score (Beta: 0.609, 95% CI: 0.236,0.981; p=0.048), the better the treatment effect. However, higher adolescent family conflict (Beta: -0.838, 95% CI: -1.377,-0.298; p=0.024) were associated with lower treatment outcomes. The greater the cognitive difference between parents and adolescents in family cohesion (Beta: -1.307, 95% CI: -2.074,-0.539; p=0.014) and family conflict(Beta: -0.665, 95% CI: -0.919,-0.410; p=0.037), the worse the therapeutic effect of NSSI might be. Discussion There were certain differences in the cognition of family relationships between parents and adolescents, and subjective family relationship cognition and cognitive differences had a significant effect on the treatment effect of NSSI in adolescents. Helping them identify the cause of cognitive differences and conducting systematic family therapy from the points of difference may be another perspective to improve the treatment effect of NSSI in adolescents.
Securely Solving Linear Algebraic Equations in a Distributed Framework Enhanced With Communication-Efficient Algorithms

Solving linear algebraic equations (a.k.a., an LAE problem) distributedly in a network with multiple agents has wide applications in distributed control, estimation, and signal processing. A consensus-based distributed computing framework is studied in this paper. Specifically, each agent knows only a subproblem of the LAE, i.e., a subset of all equations, and then all agents apply a consensus-based algorithm to update their estimates of the correct solution of the LAE problem iteratively. Under certain conditions, it has been shown that all the estimates converge to the exact solution exponentially fast. However, such a distributed paradigm is vulnerable to malicious behaviors in an adversarial environment. In this paper, we indicate a number of security threats in this process, and thus develop robust computing solutions against those attacks. With particular attention to low storage overhead, we develop a new alternating projection method to enhance the consensus algorithm. Furthermore, we design an innovative misbehavior detection mechanism by exploiting the homomorphic signature technique. Our method can detect misbehaving agents without the common, yet sometimes infeasible, assumption of local good majority. Another significant contribution presented in this paper is an original component dropping approach for mitigating the communication overhead during the consensus process. From both theoretical and engineering perspectives, we study how the consensus can still be reached when a big portion of elements in exchanged message vectors are dropped. In our preliminary numerical results, roughly 80<inline-formula><tex-math notation="LaTeX">$\%$</tex-math></inline-formula> data transmission can be reduced per epoch at the expense of 35<inline-formula><tex-math notation="LaTeX">$\%$</tex-math></inline-formula> extra epochs to reach the consensus, implying 73<inline-formula><tex-math notation="LaTeX">$\%$</tex-math></inline-formula> reduction in terms of the communication overhead.
Assigning function to active site residues of Schistosoma mansoni thioredoxin/glutathione reductase from analysis of transient state reductive half-reactions with variant forms of the enzyme

Thioredoxin/glutathione reductase (TGR) from the platyhelminthic parasitic worms has recently been identified as a drug target for the treatment of schistosomiasis. Schistosomes lack catalase, and so are heavily reliant on the regeneration of reduced thioredoxin (Trx) and glutathione (GSH) to reduce peroxiredoxins that ameliorate oxidative damage from hydrogen peroxide generated by the host immune response. This study focuses on the characterization of the catalytic mechanism of Schistosoma mansoni TGR (SmTGR). Variant forms of SmTGR were studied to assign the function of residues that participate in the electron distribution chain within the enzyme. Using anaerobic transient state spectrophotometric methods, redox changes for the FAD and NADPH were observed and the function of specific residues was defined from observation of charge transfer absorption transitions that are indicative of specific complexations and redox states. The C159S variant prevented distribution of electrons beyond the flavin and as such did not accumulate thiolate-FAD charge transfer absorption. The lack of this absorption facilitated observation of a new charge transfer absorption consistent with proximity of NADPH and FAD. The C159S variant was used to confine electrons from NADPH at the flavin, and it was shown that NADPH and FAD exchange hydride in both directions and come to an equilibrium that yields only fractional FAD reduction, suggesting that both have similar reduction potentials. Mutation of U597 to serine resulted in sustained thiolate-FAD charge transfer absorption and loss of the ability to reduce Trx, indicating that the C596-U597 disulfide functions in the catalytic sequence to receive electrons from the C154 C159 pair and distribute them to Trx. No kinetic evidence for a loss or change in function associated with the distal C28-C31 disulfide was observed when the C31S variant reductive half-reaction was observed. The Y296A variant was shown to slow the rate of but increase extent of reduction of the flavin, and the dissociation of NADP+. The H571 residue was confirmed to be the residue responsible for the deprotonation of the C159 thiol, increasing its reactivity and generating the prominent thiolate-FAD charge transfer absorption that accumulates with oxidation of the flavin.
A Subthreshold Biased CMOS Ring Oscillator Model Design in 180-nm Process

In this paper, a 180-nm CMOS ring oscillator design, made with halo-implanted transistors and operating in the weak inversion region, is proposed, based on an undergraduate integrated circuit design course methodology for building logic gates and comparing simulated results with reviewed literature data. Halo-implanted channel transistors have a steeper and less distorted voltage characteristic curve compared to uniformly doped channel ones, which makes them a more appropriate option when designing asynchronous digital integrated circuits aimed at low bias and low power. Three gate models were created using weak inversion and pull-up and pull-down networks made with halo-implanted transistors. The results of the study and simulation of the three inverter digital gate topologies showed that the NOT inverter model, as expected, had a higher frequency than the NAND and NOR inverter models. The ring oscillators made with the NOT inverter came up with an 8.25-MHz switching frequency as well as a dynamic power close to 270 nW. A comparison with other ring oscillators from previous studies is also shown.
Collaborating for nature-based solutions: bringing research and practice together

ABSTRACT Nature-based solutions (NBS) is a relatively novel concept and real-world application has only started to proliferate in cities, which motivates addressing early attempts of cross-boundary collaboration for implementing NBS. The aim of this paper is to reflect about the process of transdisciplinary research-practice collaboration on NBS and its associated learnings, potentials and challenges. To do so, this paper reflects on one of the local urban-regional innovation partnerships within the Naturvation research project, which included urban planning practitioners, researchers and public and private organisations, and aimed to understand what NBS can achieve in cities and how to advance implementation through collaboration. This paper is based on embedded research and uses participant observation as methodological inspiration. It draws on two streams of literature to frame the reflections; (a) transdisciplinary research, to reflect on the collaborative process of research and practice engaging in learning and knowledge co-production and (b) boundary concepts, to capture the boundary-spanning nature of NBS. Observations, grey literature and the “network compass” [Schneider, F. , T. Tribaldos, C. Adler, R. O. Biggs, A. de Bremond, T. Buser, C. Krug et al. 2021. “Co-Production of Knowledge and Sustainability Transformations: A Strategic Compass for Global Research Networks. ” Current Opinion in Environmental Sustainability 49: 127–142. https://doi.org/10.1016/j.cosust. 2021.04. 007] were used ex-post to identify and map fields of action and associated potentials and challenges. The process included joint problem understanding and building relations, visioning and creation of roadmaps, targeted collaboration and horizontal learning. This paper suggests that future research-practice collaboration on NBS should focus on relational capacities and communicative skills, and integrating joint reflection and learning as central components for co-producing knowledge. Furthermore, transdisciplinary collaboration requires facilitation and management skills, which should be considered an area of expertise and not taken for granted.
Beam‐scanning leaky‐wave antenna based on CRLH‐metamaterial for millimetre‐wave applications

This paper presents empirical results of an innovative beam-scanning leaky-wave antenna (LWA), which enables scanning over a wide angle from - 35° to + 34.5° between 57 and 62 GHz, with broadside radiation centred at 60 GHz. The proposed LWA design is based on composite right/left-handed transmission-line (CRLH-TL) concept. The single-layer antenna structure includes a matrix of 3 × 9 square slots that is printed on top of the dielectric substrate; and printed on the bottom ground-plane are Π- and T-shaped slots that enhance the impedance bandwidth and radiation properties of the antenna. The proposed antenna structure exhibits metamaterial property. The slot matrix provides beam scanning as a function of frequency. Physical and electrical size of the antenna is 18.7 × 6 × 1.6 mm 3 and 3. 43λ 0 × 1. 1λ 0 × 0. 29λ 0 , respectively, where λ 0 is free space wavelength at 55 GHz. The antenna has a measured impedance bandwidth of 10 GHz (55-65 GHz) or fractional bandwidth of 16.7%. Its optimum gain and efficiency are 7.8 dBi and 84.2% at 62 GHz.
Seasonal and circadian patterns of herring gull (Larus smithsoniansus) movements reveal temporal shifts in industry and coastal island interaction

Anthropogenic food subsidies attract opportunistic generalists like gulls in high densities, which may lead to negative impacts on human communities and local ecosystems. Managing impacts requires understanding why gulls use particular natural or industrial sites at different times of day or phases of the breeding cycle. Use of natural and human‐influenced habitats likely varies temporally as gulls alter schedules and site selection to match the predictability of different resources as they vary through space and time relative to patterns in human activities (seasonal industries, the work week, working hours) and natural rhythms (daylight, tide cycles), while gull resource requirements and restrictions to movement also shift with changing reproductive demands. We quantified seasonal and circadian patterns in American herring gull (Larus smithsoniansus) interactions with anthropogenic and natural sites throughout breeding using GPS data from 15 gulls tracked over 3 years from two colonies. We examined the weekly probability of gull occurrence at distinct destinations (e.g. breeding colony, islands, offshore, fish processing plants), and how occurrence varied with time of day, weekday/weekend, tide phase and colony, using GLMMs with a binomial response for destination‐specific occurrence. Probability at the colony varied predictably through the breeding season (highest attendance from dusk to dawn, during incubation and early chick rearing), providing confidence in the modelling approach for detecting temporal patterns in behaviour. Gulls visited other islands mostly outside incubation and early chick rearing, and from dusk through the night, likely roosting. Occurrence offshore where interaction with fishing vessels is possible was highest from dusk to dawn, and differed among colonies, but was the most likely destination during incubation and early chick rearing. Occurrence at fish plants gradually increased until after fledging when attendance was highest from Aug‐Oct coincident with the peak of Atlantic herring (Clupea harengus) processing and was more likely during the weekdays, during working hours, and during low and flood tide. Gulls in southwest Nova Scotia, Canada, have the behavioural flexibility to adapt to both natural rhythms and human schedules when beneficial, enabling them to thrive in a region where industry and natural resources are abundant. These findings can provide information to guide when and where to test different subsidy management strategies locally, while also considering potential increased pressures on island ecosystems. We emphasise that management outcomes of reductions of food subsidies for opportunistic species depend on multiple factors, including availability of alternative food sources and timing of use.
Augmented tour construction heuristics for the travelling salesman problem

Tour construction heuristics serve as fundamental techniques in optimizing the routes of a traveling salesman. These heuristics remain significant as foundational methods for generating initial solutions to the Traveling Salesman Problem (TSP), facilitating subsequent applications of tour improvement heuristics. These heuristics effectively comprise the iterative application of city node selection and insertion. However, thus far, no attempts have been made to enhance the basic structure of tour construction heuristics to bring a better initial solution for the advanced heuristics. This study aims to enhance tour construction heuristics without compromising their theoretical complexity. Specifically, an iterative step of partial tour deconstruction has been introduced to the existing heuristics. This additional step has been implemented and evaluated with three highly performing tour construction heuristics: the farthest insertion heuristic, the max difference insertion heuristic, and the fast max difference insertion heuristic. The results demonstrate that augmenting these heuristics with the partial tour deconstruction step improves the best, worst, and average solutions while preserving their theoretical complexity
Predicting the Future Performance of the Planned Seismic Network in Mainland China

The new broadband seismic network in China will increase the number of stations from approximately 950 to 2000. The higher-resolution monitoring of the frequent smaller earthquakes expected inside Mainland China can be quantified via the completeness magnitude (Mc) metric. Using the Bayesian Magnitude of Completeness (BMC) method, we generate the spatial distribution of Mc predicted for the new network, based on the prior model calibrated on the current earthquake catalog (2012 to 2021) and network configuration. If 99% of Mainland China is at present covered down to Mc = 2.7, this threshold will soon fall to Mc = 2.0. This means approximately 3 times more earthquakes available per year. Based on the observation that seismic precursors are most likely to be observed at least at 3 units below the mainshock magnitude, the new seismic network shall achieve the goal of almost total coverage for optimal seismic-based earthquake prediction research.
Archaeome structure and function of the intestinal tract in healthy and H1N1 infected swine

Background Methanogenic archaea represent a less investigated and likely underestimated part of the intestinal tract microbiome in swine. Aims/Methods This study aims to elucidate the archaeome structure and function in the porcine intestinal tract of healthy and H1N1 infected swine. We performed multi-omics analysis consisting of 16S rRNA gene profiling, metatranscriptomics and metaproteomics. Results and discussion We observed a significant increase from 0.48 to 4.50% of archaea in the intestinal tract microbiome along the ileum and colon, dominated by genera Methanobrevibacter and Methanosphaera. Furthermore, in feces of naïve and H1N1 infected swine, we observed significant but minor differences in the occurrence of archaeal phylotypes over the course of an infection experiment. Metatranscriptomic analysis of archaeal mRNAs revealed the major methanogenesis pathways of Methanobrevibacter and Methanosphaera to be hydrogenotrophic and methyl-reducing, respectively. Metaproteomics of archaeal peptides indicated some effects of the H1N1 infection on central metabolism of the gut archaea. Conclusions/Take home message Finally, this study provides the first multi-omics analysis and high-resolution insights into the structure and function of the porcine intestinal tract archaeome during a non-lethal Influenza A virus infection of the respiratory tract, demonstrating significant alterations in archaeal community composition and central metabolic functions.
The CRYSTAL-FACE Mission

The Cirrus Regional Study of Tropical Anvils and Cirrus Layers - Florida Area Cirrus Experiment (CRYSTAL-FACE) was a measurement campaign designed to investigate tropical cirrus cloud physical properties and formation processes. Understanding the production of upper tropospheric cirrus clouds is essential for the successful modeling of the Earth's climate. The mission was staged in July 2002 with flights of 6 aircraft from Key West, Florida. Several aircraft were used for in situ and remote sensing of aerosols, ice crystals, meteorological fields, radiative fluxes, and gas concentrations. The NASA ER-2 and WB-57, the Proteus aircraft, owned by Northrop Grumman and operated by Scaled Composites, CIRPAS provided the DeHavilland UV-l8A, "Twin Otter" aircraft, the University of North Dakota provided a Cessna Citation II aircraft , and NSF supported the ELDORA radar onboard the Naval Research Laboratory P-3 aircraft. In this presentation, I will describe some of the flights, the conditions, and some of the results from the mission.
$F0$ Estimation and Voicing Detection With Cascade Architecture in Noisy Speech

As a fundamental problem in speech processing, pitch tracking has been studied for decades. While strong performance has been achieved on clean speech, pitch tracking in noisy speech is still challenging. Severe non-stationary noises not only corrupt the harmonic structure in voiced intervals but also make it difficult to determine the existence of voiced speech. Given the importance of voicing detection for pitch tracking, this study proposes a neural cascade architecture that jointly performs pitch estimation and voicing detection. The cascade architecture optimizes a speech enhancement module and a pitch tracking module, and is trained in a speaker-independent and noise-independent way. It is observed that incorporating the enhancement module improves both pitch estimation and voicing detection accuracy, especially in low signal-to-noise ratio (SNR) conditions. In addition, compared with frameworks that combine corresponding single-task models, the proposed multi-task framework achieves better performance and is more efficient. Experimental results show that the proposed method is robust to different noise conditions and substantially outperforms other competitive pitch tracking methods.
Preventive and Therapeutic Effects of Total Flavonoids of Willow Buds on Acute Pancreatitis in Mice

Zhang et al. : Effects of Total Flavonoids of Willow Buds on Acute Pancreatitis in Mice To explore the preventive and therapeutic effects of total flavonoids of willow buds on acute pancreatitis is the objective of the study. The willow buds of Salix babylonica L. (~1 cm) were harvested from Shenyang Institute of Technology between March 2020 to April 2020. Ultrasound-assisted extraction of total flavonoids of willow buds was conducted and an L-arginine-induced acute pancreatitis mouse model was established. The content of naringenin was determined by Agilent 1100 high-performance liquid chromatography. Serum biochemical test, serum oxidation test and plasma leukocyte content was determined and HE staining was performed. The protective and therapeutic effects of total flavonoids of willow buds on acute pancreatitis in mice were investigated. Total flavonoids of willow buds effectively decreased the activity of serum amylase, lipase and malondialdehyde, reduced plasma white blood cells and increased serum calcium content and superoxide dismutase activity in acute pancreatitis mice; total flavonoids of willow buds alleviated the pathological injury of the pancreas in acute pancreatitis mice. In conclusion, total flavonoids of willow buds may reduce pancreatic injury via reducing the inflammatory response and increasing the activity of antioxidant enzymes, which is a promising natural anti-acute pancreatitis drug.