Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypoxia preconditioning promotes mesenchymal stem cells survival and vascularization through the activation of MALAT1/miR-195/VEGFA axis

Background: Previous studies have demonstrated that hypoxia preconditioning (HP) can promote mesenchymal stem cells (MSCs) survival and vascularization. Long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a newly discovered regulator of MSCs viability and differentiation. Evidences have indicated that MALAT1 can be strongly induced by hypoxia. This study aimed to investigate the role of MALAT1 in HP mediated MSCs survival and vascularization as well as the relevant underlying mechanism in vitro.Methods: MSCs were obtained from C57BL/6 mice and cultured in vitro. Cells at the third passage were divided into the following groups: normoxia (N), hypoxia preconditioning (HP), HP + MALAT1, HP + MALAT1 NC, HP+si-MALAT1 and HP +si-MALAT1 NC. The normoxia group was cultured in 20% O2 for 24 h. All the other groups were exposed to hypoxia (1% O2) for 24 hours. MALAT1 and relevant scramble RNA were transfected in the HP+MALAT1 and HP+MALAT1 NC groups respectively. HP+si-MALAT1 and HP +si-MALAT1 NC groups were transfected with MALAT1 siRNA and relevant siRNA scramble respectively. MSCs proliferation, apoptosis and vascular densities were evaluated. Bioinformatics and dual luciferase reporter assay were performed. Relevant biomarkers were examined in different experimental groups.Results: MSCs survival and vascularization were significantly enhanced in the HP group. Transfection of MALAT1 further strengthened the viability and angiogenic potential of MSCs in the condition of HP, whereas its knockdown attenuated cells survival and vascularization. MALAT1 and vascular endothelial growth factor A (VEGFA) were obviously increased after hypoxia exposure, while miR-195 was decreased. miR-195 targeted and downregulated VEGFA. miR-195 was a target of MALAT1. Overexpression of MALAT1 led to a decreased level of miR-195, accompanied with an augmented expression of VEGFA. However, both miR-195 and VEGFA exhibited contrary alterations after MALAT1 blockage. Conclusion: HP enhanced MSCs survival and vascularization potential in vitro, and the activation of MALAT1/miR-195/VEGFA axis might be involved in this procedure. This study reveals a new molecular mechanism of HP mediated MSCs survival and vascularization. It will be conducive for the development of novel strategies to improve the therapeutic efficiency of MSCs based on HP.
Motivational analysis of tourists who visit a city with inscriptions World Heritage Site, Granada, Spain

In recent times, it has been noticed that cultural tourism attracts millions of people. One interesting aspect is the analysis of WHS (World Heritage Site) destinations or cultural destinations that have an inscription WHS. This research has the goal of analysing the different groups of tourists who visit a cultural destination with an inscription WHS, specifically the city of Granada (Spain). For this, segmentation was performed, studying the socio-demographic profile of the tourists and their assessment of the attributes of this destination. For the tourist segmentation, two models have been followed. Four different groups of tourists were found: alternative, cultural, emotional and heritage. In this last one, the relationship between curiosity about the culture of the tourist destination and the heritage visited has a determining role. This study makes an important contribution to the literature regarding the links between the tourist and the historic and monumental heritage they visit and their tourist behaviour.
Improving project management skills and techniques

Presents basic elements needed for organizing, scheduling, monitoring, and controlling various types of projects common in business, industry, and construction. Integrates computer software to address needs of project management. Presents basic elements needed for organizing, scheduling, monitoring, and controlling various types of projects common in business, industry, and construction. Integrates computer software to address needs of project management.
MANAGEMENT OF ARTERIAL COMPLICATIONS AFTER LIVING DONOR LIVER TRANSPLANTATION

Background: Liver transplantation is perceived as the only curative treatment for patients with end-stage liver disease. Arterial complications are one of the most serious complications after living donor liver transplantation (LDLT). Aim of the work: To assess the different modalities of management and outcome of early and late arterial complications and to analyze the risk factors of such complications after living donor liver transplantaiton. Patients and Methods: This is a retrospective study in which 293 LDLT operations were done between 2008 and May 2017 at Ain Shams center for organ transplantation ( ASCOT ). After approval of Ethics committee and the research council, Ain shams university school of medicine, we did this retrospective cohort study that analyzed the incidence, risk factors, management and outcome of HA complications in adults and pediatrics recipients in the period from 2008 to May 2017, where patients were observed from POD 1 until the end 2017 or until death of patients. Results: In our study early arterial complications are more higher and more serious than late arterial complications. Mortality rate in patients with early complications exceeds 50%. In late complications it was 20%. Conclusion: Urgent surgical management is life saving in cases of early hepatic artery thrombosis (HAT). Arterial reconstruction is technically difficult. LD retransplant has been performed in a very small number worldwide. Emergency living donor retransplantation is life saving in cases of early (HAT). Arterial reconstruction using left gastric artery and splenic artery is feasible in LD retransplant and arterial reconstruction after HAT. Early diagnosis and surgical or radiological intervention is the corner stone to save the recipient.
REVISÃO SISTEMÁTICA DE ESTUDOS SOBRE COMPUTAÇÃO DESPLUGADA NA EDUCAÇÃO BÁSICA E SUPERIOR DE 2014 A 2020: TENDÊNCIAS NO CAMPO

Este artigo tem como objetivo apresentar uma Revisão Sistemática da Literatura (RSL) de publicações científicas sobre Computação Desplugada (CD) na Educação Básica e no Ensino Superior, publicadas de 2014 a 2020 em alguns dos principais meios acadêmicos brasileiros relacionados à Computação e Educação: SBIE, WIE, WCBIE, RBIE, RENOTE, WEI, WIT e ANPED. Para tanto, seguiram-se as etapas definidas no protocolo de pesquisa e a consulta às bases de dados eletrônicos. Dos estudos pesquisados, foram selecionados para análise sessenta e sete que atenderam aos critérios de inclusão estabelecidos. Os principais resultados indicam que há um aumento nas pesquisas quanto ao uso da CD na Educação Básica, especialmente no Ensino Fundamental e em escolas públicas. A maior parte dos estudos se baseia nas atividades do livro Computer Science Unplugged e em atividades desplugadas autorais. Os conceitos mais trabalhados nos estudos são Algoritmo, Lógica de Programação e Números Binários. A maioria dos estudos analisados são desenvolvidos sem associação explícita a alguma disciplina da Base Nacional Curricular Comum (BNCC).
Preventing Stroke in Sickle Cell Disease: 2021. The Role of Transcranial Doppler Ultrasound (TCD) When the Use of Transfusion is Problematic

In 2009, as an invited Commentary to the article: “STOP” ing the Harm: When is State Intervention Justified? [1], I wrote that while TCD is an indicator of risk, not a biopsy diagnosis (such as proof of cancer), at some point in the velocity spectrum the high velocity detected by TCD reaches what many—myself included--believe is an unacceptable risk of stroke [2]. Even at the low end of the intervention window, 200 cm/sec Time Averaged Mean of the Maximum (TAMM), the point where periodic transfusion is recommended based on the STOP Trial [3], the risk is at least 10 times background and it goes up from there. The risk is markedly attenuated (>90%) by transfusion. Stroke by its nature is permanent. While some strokes are minor and survival with recovery is the expected outcome, it is not assured.
Analysis of the Vibration of the Input Bevel Pinion in RAN (Royal Australian Navy) Wessex Helicopter Main Rotor Gearbox WAK143 Prior to Failure.

Abstract : Following the crash of an RAN Wessex helicopter caused by the catastrophic fatigue failure of the input spiral bevel pinion in the main rotor gearbox, routine recordings of the gearbox vibration have been analyzed by ARL. It has been shown that conventional spectral analysis of the vibration is unable to give adequate indication of the presence of the fatigue crack but that an alternative technique of vibration analysis called signal averaging can give warning of the crack 42 hours before failure. Enhancement of the signal average using a computer enables detection of the crack as early as 103 hours before failure.
Arabic For Dummies

Introduction. Part I: Getting Started. Chapter 1: You Already Know a Little Arabic. Chapter 2: The Nitty-Gritty: Basic Arabic Grammar. Chapter 3: 'as-salaamu 'alaykum! : Greetings and Introductions. Part II: Arabic in Action. Chapter 4: Getting to Know You: Making Small Talk. Chapter 5: This Is Delicious! Eating In and Dining Out. Chapter 6: Going Shopping. Chapter 7: Around Town. Chapter 8: Enjoying Yourself: Recreation. Chapter 9: Talking on the Phone. Chapter 10: At the Office and Around the House. Part III: Arabic on the Go. Chapter 11: Money, Money, Money. Chapter 12: Asking for Directions. Chapter 13: Staying at a Hotel. Chapter 14: Getting from Here to There: Transportation. Chapter 15: Planning a Trip. Chapter 16: Handling an Emergency. Part IV: The Part of Tens. Chapter 17: Ten Ways to Pick Up Arabic Quickly. Chapter 18: Ten Things You Should Never Do in an Arab Country. Chapter 19: Ten Favorite Arabic Expressions. Chapter 20: Ten Great Arabic Proverbs. Part V: Appendixes. Appendix A: Verb Tables. Appendix B: Arabic-English Mini-Dictionary. Appendix C: Answer Key. Appendix D: About the CD. Index.
Error free WDM transmission of 8x10 Gbit/s over km of LEAF optical fiber

The performance of a novel non-zero dispersion-shifted large effective area fiber in a wavelength division multiplexing (WDM) system is described. Error-free transmission for 8x10 Gbit/s in the red band and 4x10 Gbit/s in the blue band over 450 km (5 x 90 km) is achieved. No four-wave mixing components were observed due to the large effective area of LEAF fiber.
Enhancing student learning through the assessment of outcomes:developing and demonstrating essay writing skills

This paper documents current developments in the UK Open University (UK/OU) with reference to the requirement in the UK that all Higher Education institutions now have to describe their programmes in terms of learning outcomes. In response to this, the UK/OU set up a three-year Learning Outcomes and Their Assessment (LOTA) Project to explore and implement an outcomes-based approach to curriculum design and delivery throughout the university. The intended learning outcomes for all courses and all programmes of study have now been documented in course and programme specifications. Currently the challenge is to ensure that assessment strategies and assessment methods support the development of the stated outcomes and enable them to be appropriately assessed. The LOTA Project has always seen assessment as part of the learning process through both formative and summative assignments. In many OU courses academic essays are used to assess students work, both throughout a course and in the final examination. The paper goes on to describe an action research project that set out to examine the extent to which assessment through essays encouraged students to both develop and demonstrate the outcomes claimed by each course. The aim of the project was to explore the process of essay writing and essay marking. It involved pairs of tutors who exchanged and double-marked the essays of two of their students throughout the course and met at the end of the year to compare their experiences. The assessment materials provided by the course team were examined and the progress of the students analysed through their essays. The evidence suggests that essay writing can be used to assess learning outcomes but that present practice shows these are not explicit and that many students fail to demonstrate them. With clearer guidance to tutors and to students, both cognitive and communication skills could be developed more effectively and assessed more rigorously. The findings contribute to on-going work to find better ways of enhancing students' learning through the articulation and assessment of outcomes. The paper concludes that moving towards an outcomes-based curriculum, with appropriate assessment strategies, can enhance student learning but the process needs to be more transparent and to explicitly encourage a meta-cognitive approach.
Mechanically Mediated Crosstalk in Heart

This review covers aspects of the cardiac mechanotransduction field at different levels, and advocates the possibility that mechanoelectro-chemical transduction forms part of a network of mechanically linked crosstalk in heart – Mechanically Mediated Crosstalk (MMC). It assembles evidence and observations in the literature to promote this hypothesis. Mechanical components can provide the bond between interactions at molecular, cellular, and macro levels to enable the crosstalk. Stretch activated channels exist in heart, but stresses and strains can affect other membrane channels or receptors. A cellular mechanical change can thus promote several ionic or downstream changes. Cell signal cascades have been implicated and, mostly via intracellular Ca, can affect membrane electrophysiology. MMC could shape downstream signals to alter intracellular Ca. MMC also spans other regulatory systems and processes, such as the autonomic nervous system, and in addition, operates through to the whole heart as an integrative system. Finally, supporting the hypothesis, if elements of the normal crosstalk become deranged it contributes to cardiovascular disease and, potentially, lethal arrhythmia.
Financial Forecasting Using Evolutionary Computational Techniques

Financial forecasting or specially stock market prediction is one of the hottest field of research lately due to its commercial applications owing to high stakes and the kinds of attractive benefits that it has to offer. In this project we have analyzed various evolutionary computation algorithms for forecasting of financial data. The financial data has been taken from a large database and has been based on the stock prices in leading stock exchanges . We have based our models on data taken from Bombay Stock Exchange (BSE), S&P500 (Standard and Poor’s) and Dow Jones Industrial Average (DJIA). We have designed three models and compared those using historical data from the three stock exchanges. The models used were based on: 1. Radial Basis Function parameters updated by Particle swarm optimization. 2. Radial Basis Function parameters updated by Least Mean Square Algorithm. 3. FLANN parameters updated by Particle Swarm optimization. The raw input for the experiment is the historical daily open, close, high, low and volume of the concerned index. However the actual input to the model was the parameters derived from these data. The results of the experiment have been depicted with the aid of suitable curves where a comparative analysis of the various models is done on the basis on various parameters including error convergence and the Mean Average Percentage Error (MAPE). Key Words: Radial Basis Functions, FLANN, PSO, LMS
FLOW STABILIZATION AND ENHANCED TRAFFIC PERFORMANCE USING INTER-VEHICLE COMMUNICATION AND DISTRIBUTED INTELLIGENCE

This paper demonstrates stabilization of traffic flow and potentially increased highway capacity resulting from a novel, intelligent, in-vehicle speed adaptation algorithm based on medium-range inter-vehicle communication (IVC). The implemented algorithm stabilizes traffic flow on highways by using this data to essentially remove oscillation energy from unstable traffic oscillation modes and thus damp incipient stop-and-go waves. In a refinement, extended floating car data will be used to detect and monitor positions of sharp speed gradients, jam entrances and end positions. The results provide further support for the use of IVC to make traffic flow intelligent and find sustainable solutions to congestion and traffic safety. For the covering abstract see E134653.
Maternal efficiency in beef cattle is not compromised by selection for leanness or feed efficiency

Beef cattle producers are concerned that selecting for carcass traits such as leanness, or for increased feed efficiency, might be deleterious to maternal efficiency and limit the use of genetic improvement technologies such as Estimated Breeding Values (EBVs). We define maternal efficiency by production parameters such as days to calving, birth weight, growth rate, weaning weight, as well as efficiency measures such as total intake and kg weaned per megajoule of metabolisable energy consumed per cow calf unit – kg weaned/MJ ME intake. Selecting for leanness in cattle is of economic benefit due to the relationship to higher yielding carcasses (Nkrumah et al., 2004). Net Feed Intake (NFI) is a trait used to measure feed efficiency in beef cattle, and is calculated as the actual amount of feed eaten by an individual animal less the expected amount of feed consumed based on the animal’s growth rate and body weight (Koch et al., 1963). Low NFI (high efficiency) is economically desirable due to the potential to reduce feed costs and increase stocking rates. Both traits affect the body condition of dams and this is closely linked to maternal traits in cattle (Morris on et al., 1999; Roche et al., 2000; Meikle et al., 2004). This experiment aims to quantify the impact on the breeder herd of selection for leanness or feed efficiency over three breeding cycles. The impact of level of nutrition was also assessed.
Schools in Disadvantaged Areas: Recognising Context and Raising Quality

Both educational attainment and school quality are typically lower in disadvantaged areas than others and much recent policy attention has been focused on each. This paper looks at the quality problem, exploring the relationships between disadvantaged contexts, what schools do, and the quality of schooling that they provide. The findings suggest that disadvantaged contexts impact on the organisation and processes of schools and that these effects differ significantly from one area to another, in ways that are not reflected by the usual indicators of disadvantage. School managers respond by adapting organisational design and processes. They are, however, constrained in these responses by the limited and short-life funding available, by the lack of evidence of good practice in specific contexts, and by lack of flexibility over major issues of organisation design and curriculum. Challenging contexts and the constraints on school responses together exert a downward pressure on quality. The paper argues that because school processes and quality are affected by context, school improvement in disadvantaged areas will not be achieved by generic measures, but only by policies tailored to disadvantaged areas and sensitive to differences between these areas. It suggests ways in which school improvement policies could be contextualised in order to raise quality in the poorest areas.
Runway image shape as a cue for judgment of approach angle.

Abstract : One cue for visual judgment of glidepath angle has been referred to as form ratio. Form ratio is defined as the ratio of vertical height of the runway to width of the far end in the runway retinal image. The ability of pilots to judge form ratios was compared with the ability to judge approach angles in the nighttime 'black hole' situation in two experiments. In one experiment, 16 pilots observed a stationary model of a lighted airport runway under nighttime conditions at different simulated approach angles from a simulated distance of 8,000 ft from threshold. Pilots made verbal judgments of approach angle using the categories 'low,' 'high,' and 'OK,' and on half the trials also estimated form ratios. In the second experiment, 20 pilots made observations both in a similar static condition at simulated distances of 8,000 ft and 26,000 ft from threshold, and in a dynamic condition in which they controlled the model to produce (i) specified values of form ratio (1.0, 2.0, and 3.0) or (ii) a 3 deg approach angle, as the model approached them between 8,000 and 26,000 ft. The simulated approach speed was 125 knots. Responses in both static and dynamic conditions indicated a general tendency to over-estimate form ratios and approach angles less than 3 deg. Intersubject and intrasubject variability of form ratio and approach angle responses were comparable.
Establishing STEM educational leadership: the RMIT SHEER centre

The disciplines of Science, Technology, Engineering and Mathematics (STEM) are critical for Australia's national productivity and global competitiveness. Demand for tertiary graduates with STEM skills will continue to exponentially exceed supply in Australia in the next 25 years. Leadership in the promotion of STEM learning and teaching is critical to the development of future graduates to meet these needs. Over the past three years, the College of Science, Engineering and Health at RMIT University has undertaken extensive consultations and research to develop a model of educational leadership for tertiary staff in the STEM disciplines. This paper reports upon the data collection and consultation processes involved in the establishment of a STEM educational research centre. By drawing together STEM discipline scholars, best practice learning and teaching and industry-led work-integrated learning, a Science, Health and Engineering Educational Research (SHEER) Centre has been created to provide leadership, management and strategic direction of STEM educational research. The new Centre is expanding cross-disciplinary learning opportunities through the introduction of workshops that connect industry, staff and students in emerging industry-focussed STEM initiatives.
Zastosowanie odpornego sterowania siłowego w manipulatorze rehabilitacyjnym

Streszczenie Artykul prezentuje zastosowanie metody sterowania odpornego Active Disturbance Rejection Control (ADRC) w ukladzie regulacji z modelem manipulatora robotycznego do zadan wspomagania rehabilitacji stawu kolanowego. Ze wzgledu na wielowymiarowośc badanego manipulatora oraz obecnośc w nim silnie nieliniowych, zmiennych w czasie oraz sprzezonych skrośnie elementow dynamiki, sterowanie rozwazanym systemem jest zadaniem nietrywialnym. Niepewnośc modelowania moze byc jednak w technice ADRC na bieząco odsprzegana od systemu, zwiekszając tym samym jego odpornośc parametryczną i zakloceniową. W artykule przedstawiono wyniki eksperymentalne dzialania podejścia ADRC dla dwoch przypadkow: treningu izometrycznego oraz izotonicznego. Otrzymane rezultaty pozwalają stwierdzic, ze metoda ADRC stanowi interesującą alternatywe dla klasycznych technik sterowania stosowanych w manipulatorach rehabilitacyjnych.
LEGAL FORM AND CULTURAL SYMBOL

Writers in information and communication studies often assume the stability of objects under investigation: network nodes, databases, information. Legal writers in the intellectual property tradition often assume that cultural artefacts exist as objects prior to being governed by copyright law. Both assumptions are fallacious. This introduction conceptualizes the relationship of legal form and cultural symbol. Starting from an understanding of copyright law as part of systems of cultural production, it is argued that copyright law constructs the artefacts it seeks to regulate as objects that can be bought and sold. In doing so, the legal and aesthetic logic of cultural symbols may clash, as in the case of digital music (the central focus of this special issue).