Miracle-dz/UniFAR-FTUs huggingface dataset:
18 months follow-up of deep molecular response 4.5 (MR4.5) with nilotinib in patients with newly diagnosed chronic-phase chronic myeloid leukemia: a prospective, multi-center study in China

Introduction Early stable deep molecular response (DMR) to nilotinib is associated with goal of treatment-free remission (TFR) in patients with chronic-phase chronic myeloid leukemia (CML-CP). It is important to early distinguish between patients who can achieve a DMR and those who are fit for TFR. Methods We performed a multicenter study to explore the early cumulative MR4.5 rate at 18 months with nilotinib in patients with newly diagnosed CML-CP (ND-CML-CP) in China. Of the 29 institutes, 106 patients with ND-CML-CP received nilotinib (300 mg BID). Results and discussion The cumulative MR4.5 rate of nilotinib treatment at 18 months was 69.8% (74/106). The cumulative MMR and MR4.0 rates for nilotinib at 18 months were 94.3% (100/106) and 84.9% (90/106), respectively. Patients with an ultra-early molecular response (u-EMR) at 6 weeks were not significantly different in obtaining DMR or MMR by 24 months compared with those without u-EMR (p = 0.7584 and p = 0.9543, respectively). Our study demonstrated that nilotinib treatment in patients with ND-CML-CP contributed to obtain high early MR4.5.
Identification of CDK1, PBK, and CHEK1 as an Oncogenic Signature in Glioblastoma: A Bioinformatics Approach to Repurpose Dapagliflozin as a Therapeutic Agent

Glioblastoma multiforme (GBM) is the most aggressive and lethal primary brain tumor whose median survival is less than 15 months. The current treatment regimen comprising surgical resectioning, chemotherapy with Temozolomide (TMZ), and adjuvant radiotherapy does not achieve total patient cure. Stem cells’ presence and GBM tumor heterogeneity increase their resistance to TMZ, hence the poor overall survival of patients. A dysregulated cell cycle in glioblastoma enhances the rapid progression of GBM by evading senescence or apoptosis through an over-expression of cyclin-dependent kinases and other protein kinases that are the cell cycle’s main regulatory proteins. Herein, we identified and validated the biomarker and predictive properties of a chemoradio-resistant oncogenic signature in GBM comprising CDK1, PBK, and CHEK1 through our comprehensive in silico analysis. We found that CDK1/PBK/CHEK1 overexpression drives the cell cycle, subsequently promoting GBM tumor progression. In addition, our Kaplan–Meier survival estimates validated the poor patient survival associated with an overexpression of these genes in GBM. We used in silico molecular docking to analyze and validate our objective to repurpose Dapagliflozin against CDK1/PBK/CHEK1. Our results showed that Dapagliflozin forms putative conventional hydrogen bonds with CDK1, PBK, and CHEK1 and arrests the cell cycle with the lowest energies as Abemaciclib.
Huangqi-Danshen decoction protects against cisplatin-induced acute kidney injury in mice

Background: Acute kidney injury (AKI) induced by cisplatin remains a major impediment to the clinical application of cisplatin, necessitating urgent exploration for promising solutions. Huangqi-Danshen decoction (HDD), a Chinese herbal preparation, has been shown by our group to have a reno-protective effect in adenine-induced chronic kidney disease mice and diabetic db/db mice. However, the effect of HDD on cisplatin-induced AKI and its underlying mechanisms are unknown. Methods: The AKI model was established by intraperitoneal injection of cisplatin (20 mg/kg) in C57BL/6 mice. The mice in the treatment group were administrated with HDD (6.8 g/kg/d) for 5 consecutive days before cisplatin challenge. After 72 h cisplatin injection, blood and kidney tissue were subsequently collected for biochemical detection, histopathological evaluation, Western blot analysis, immunohistochemical staining, and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling assay. Ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used to detect changes in renal metabolites. Results: The results showed that HDD significantly reduced serum creatinine and blood urea nitrogen levels and alleviated renal histopathological injury in cisplatin-induced AKI mice. And HDD treatment demonstrated a significant inhibition in apoptosis, inflammation, and oxidative stress in AKI mice. Moreover, non-target metabolomics revealed that HDD significantly restored 165 altered metabolites in AKI mice. Subsequent enrichment analysis and pathway analysis of these metabolites indicated that nicotinate and nicotinamide metabolism was the primary pathway affected by HDD intervention. Further investigation showed that HDD could upregulate nicotinamide adenine dinucleotide (NAD+) biosynthesis-related enzymes quinolinate phosphoribosyltransferase, nicotinamide mononucleotide adenylyltransferase 1, and nicotinamide phosphoribosyltransferase to replenish NAD+ content in the kidney of AKI mice. Conclusion: In summary, HDD exerted a protective effect against cisplatin-induced AKI and suppressed apoptosis, inflammation, and oxidative stress in the kidney of AKI mice, which may be attributed to the modulation of NAD+ biosynthesis.
Continuous Spinal Anesthesia for Labor Analgesia and Cesarean Delivery in a Parturient With Familial Dilated Cardiomyopathy: A Case Report

We report a case of successful continuous spinal anesthesia (CSA) for labor analgesia and cesarean delivery in a patient with familial dilated cardiomyopathy (DCM). A 33-year-old pregnant woman diagnosed with DCM was scheduled for a vaginal delivery under labor analgesia. An accidental intrathecal catheter was placed, and labor analgesia was provided by CSA. The vaginal delivery was converted to a cesarean delivery, and an intrathecal catheter was used for transition, which avoided hemodynamic changes and allowed the patient to safely undergo cesarean delivery. CSA is a reliable and rapidly titratable technique that provides excellent analgesia without hemodynamic changes in patients with DCM undergoing labor analgesia and subsequent cesarean delivery.
Analysis of distribution characteristics of Hevea brasiliensis in the Xishuangbanna area based on HJ-1 satellite data

The distribution situation of the rubber tree Hevea brasiliensis in the Xishuangbanna area in 2011 was estimated using decision tree classification of HJ-1 satellite data and field sampling data.A quantitative evaluation of climatic characteristics and topography was conducted on this basis by spatial analysis in a geographic information system using digital elevation model and climatic data.The climate boundary of Hevea brasiliensis distribution as well as the range of altitude,slope and aspect tolerated by the species in the Xishuangbannaarea were determined.The results show that the classification information acquired from HJ-1 satellite data is accurate enough to allow the dynamic monitoring of key vegetation issues.Eighty percent of Hevea brasiliensis forest was found at an elevation of 600-1300 m,with a maximum of 2100 m.Ninety percent of forest was on slopes from 0-24 degrees.The species appeared not to be sensitive to aspect and to favor areas with an average annual temperature of 18C-with a maximum temperature of 25C,and minimum temperature of 14C.The relationship between slope,elevation and distribution frequency of Hevea brasiliensis can be modeled by a Gauss function.Quantification of the climatic and topographic extent of forest distribution has a significant role in the management and restoration of damaged forest ecosystems.
Texture-Semantic Collaboration Network for ORSI Salient Object Detection

Salient object detection (SOD) in optical remote sensing images (ORSIs) has become increasingly popular recently. Due to the characteristics of ORSIs, ORSI-SOD is full of challenges, such as multiple objects, small objects, low illuminations, and irregular shapes. To address these challenges, we propose a concise yet effective Texture-Semantic Collaboration Network (TSCNet) to explore the collaboration of texture cues and semantic cues for ORSI-SOD. Specifically, TSCNet is based on the generic encoder-decoder structure. In addition to the encoder and decoder, TSCNet includes a vital Texture-Semantic Collaboration Module (TSCM), which performs valuable feature modulation and interaction on basic features extracted from the encoder. The main idea of our TSCM is to make full use of the texture features at the lowest level and the semantic features at the highest level to achieve the expression enhancement of salient regions on features. In the TSCM, we first enhance the position of potential salient regions using semantic features. Then, we render and restore the object details using the texture features. Meanwhile, we also perceive regions of various scales, and construct interactions between different regions. Thanks to the perfect combination of TSCM and generic structure, our TSCNet can take care of both the position and details of salient objects, effectively handling various scenes. Extensive experiments on three datasets demonstrate that our TSCNet achieves competitive performance compared to 14 state-of-the-art methods. The code and results of our method are available at https://github.com/MathLee/TSCNet.
RRS James Cook Cruise 29, 01 Nov-22 Dec 2008: SOFine cruise report; Southern Ocean Finestructure

The SOFINE research project aims to investigate two important, inter-related aspects of the physics of the Antarctic Circumpolar Current (ACC) and the Southern Ocean overturning circulation: (a) the ‘frictional’ processes that slow down the ACC as it meanders around major bathymetric obstacles and flows over small-scale topographic roughness; and (b) the meso- and small-scale phenomena that move water masses across the ACC and modify their properties in the process. These issues will be studied using a collection of data gathered during cruise JC 29, which is described in this report. The JC 29 cruise consisted primarily of a series of transects across the standing meander that the ACC forms around the northern edge of the Kerguelen Plateau. The transects delineate a double box (Fig. 2), with the outer transects sampling the ACC as it enters and exits the meander, and the inner transect surveying the current in an area within the meander and downstream of some complex small-scale topography. During the transects, hydrographic, velocity and microstructure profiles were obtained with a CTD, lowered ADCP and VMP-5500 (a free-fall vertical microstructure profiler) suite, and quasi-continuous measurements of upperocean currents and high-resolution bathymetry were made with vessel-mounted ADCPs and a multibeam system. A variety of profiling floats (including EM-APEX, Iridium and standard Argo units) were also deployed at the upstream end of the meander, with the goal of obtaining measurements of the downstream evolution of water mass properties and both thermohaline and shear finestructure. Opportunistic measurements of upper-ocean turbulence were obtained with an ISW tethered turbulence profiler. Finally, a cluster of three short-term (2.5 weeks) moorings and two long-term (> 1 year) moorings were deployed at the southern end of the inner transect to measure the generation of internal waves by flow-topography interaction at a small ridge and the mesoscale eddy statistics of the area, respectively. The short-term moorings were successfully recovered toward the end of the cruise.
Does the ankle affect knee hyperextension during gait in hemiparetic stroke? A pilot study

Background Knee hyperextension is common following stroke because of changes in joint range of motion (ROM), muscle tone and strength on the hemiparetic side. There is no clear consensus in the literature as to the cause of knee hyperextension during the stance phase of gait. Objectives Our study aimed to determine the feasibility of methods to investigate the association between ankle joint function and knee hyperextension in patients with hemiparetic stroke during the stance phase of gait. Methods We used a cross-sectional observational study to assess bilateral ankle muscle strength using a handheld dynamometer, ROM using a digital inclinometer and muscle tone using the Modified Tardieu Scale. The knee angles of the hemiparetic leg during the stance phase of gait were assessed using the Kinovea movement analysis software. Data were analysed using the Statistical Package for the Social Sciences with significance level set at 0.05 and 95% confidence intervals. Results Twelve participants were included, and no alterations were necessary to the planned methodology. We found positive associations in six participants between the tibialis anterior muscle tone and the hemiparetic knee angles during heel strike, terminal stance and pre-swing phases (p < 0.05, p < 0.01 and p < 0.01, respectively). Conclusion The results of the data analysis suggests that there may be a correlation between tibialis anterior muscle tone and knee hyperextension, a larger study will be imperative to confirm this association. Clinical implications The methods described in our pilot study are feasible for a larger study to be conducted with the recommendations considered.
Uso del índice topográfico de humedad (ith) para el diagnóstico de la amenaza por desborde fluvial, estado trujillo-Venezuela Use of the topographic wetness index (TWI) for the diagnosis of the river overflow threat, Trujillo State-Venezuela

In this analysis, an optimal location for the building of the new Trujillo’s Social Service Hospital was determined by taking into account two main constraints: The first one is related to land availability, which by the time of this study was limited to the area between the River Castan and the Valera-Trujillo highway. The second constraint is the susceptibility of this area to debris flood processes. Therefore a debris flood hazard analysis for the area is applied to set which zones can potentially hold the hospital’s infrastructure within a minimum of flood vulnerability. This hazard analysis is mainly based on the spatial distribution of soil moisture and surface saturation, computed by the topographic wetness index (TWI), together with other derived spatial information, which was finally integrated by means of a Boolean model.
Gestion durable des sédiments : co-valorisation sédiments-fibres

Resume : Dans un contexte de gestion durable de dechets solides, des solutions de valorisation de sols fins a problemes (sediments marins et fillers de carriere) sont recherchees. La filiere de valorisation matiere retenue est basee sur d’une part, le reemploi de fibres dechets si possible, et d’autre part, la stabilisation a base de liants hydrauliques faiblement doses. Cette co-valorisation constitue une nouvelle approche innovante dans les traitements des sediments marins ou fines de carriere avec des ajouts de liants hydrauliques. Une etude preliminaire a porte dans le cas de fibres naturelles sur le caractere absorbant et la mesure du taux d’absorption. Puis une etude sur des melanges a ete entreprise dont l’objectif etait la valorisation de sediments marins de La Baule Le Pouliguen et de fillers issus de carrieres proches de Bayeux. L’application visee concerne l’elaboration d’un materiau pour le domaine routier. Sur ces melanges, l’analyse a porte sur les performances mecaniques des melanges fibres (fibres de lin, fibres geosynthetiques rigides Kevlar et lisses a base de polypropylene). Les proprietes mecaniques des melanges sont fonction du choix de la nature, de la quantite de fibres ajoutee et de leur longueur mais aussi de leurs proprietes intrinseques. Les essais consideres sont la compression simple, la traction indirecte et de mouillage-sechage. Des tendances sur les parametres optimaux ont ete mises en evidence. Mots-cles : Sediments – Filler – Fibres naturelles – Fibres geosynthetiques Valorisation – Materiau – Stabilisation/solidification – Compression – Traction – Gestion durable
Utilization of Mirror Visual Feedback for Upper Limb Function in Poststroke Patients: A Systematic Review and Meta-Analysis

Mirror visual feedback (MVF), a noninvasive treatment method, is attracting attention as a possibility to promote the recovery of upper limb function in stroke patients. However, the cognitive effects of this therapy have received limited attention in the existing literature. To address this gap, we conducted a systematic review and meta-analysis to investigate the relationship between upper limb function and cognition in stroke patients and to evaluate the effect of MVF on improving upper limb function. A comprehensive search was performed on the Embase, MEDLINE, and PubMed databases to identify original articles and clinical studies published between 2013 and 2022. Qualitative analysis was performed using the Cochrane Risk of Bias tool, and in the quantitative analysis, a random-effects model was used as the effect model, and standard mean difference (SMD) was used as the effect measure. Eight studies that met the inclusion criteria were entered in the analysis. Data extraction included an assessment tool for upper extremity function. Results of the quantitative analysis demonstrate that MVF was effective in improving upper extremity function in stroke patients (SMD = 0.94, 95% CI 0.69 to 1.20). In conclusion, this systematic review and meta-analysis provides evidence supporting the effectiveness of MVF in improving upper limb function in stroke patients. However, further studies are needed to investigate the cognitive effects of MVF and elucidate the underlying mechanisms.
Large predatory marine reptiles from the Albian–Cenomanian of Annopol, Poland

Abstract During the Early–Late Cretaceous transition, marine ecosystems in Eurasia hosted a diverse set of large predatory reptiles that occupied various niches. However, most of our current knowledge of these animals is restricted to a small number of bonebed-like deposits. Little is known of the geographical and temporal extent of such associations. The middle Albian – middle Cenomanian phosphorite-bearing succession exposed at Annopol, Poland produces numerous ichthyosaurian and plesiosaurian fossils. These are mostly isolated skeletal elements (e.g. teeth, vertebrae), but disarticulated partial skeletons and an articulated, subvertically embedded ichthyosaur skull are also available. The following taxa are identified: ‘Platypterygius’ sp. , cf. Ophthalmosaurinae, Ichthyosauria indet. , Polyptychodon interruptus, Pliosauridae indet. , Elasmosauridae indet. and Plesiosauria indet. The large-sized ichthyosaur ‘Platypterygius’ and the pliosaurid Polyptychodon interruptus predominate within the upper Albian – middle Cenomanian deposits. The Annopol record, combined with data from England, France and western Russia, suggests that ‘Platypterygius’ and Polyptychodon interruptus formed a long-term, stable ecological sympatry in marine ecosystems of the European archipelago, at least during the Albian – middle Cenomanian. In addition, the marine reptile assemblage from Annopol is distinct from other Eurasian ecosystems in containing also elasmosaurids in its Albian portion.
Exploring Human Metabolome after Wine Intake—A Review

Wine has a rich history dating back to 2200 BC, originally recognized for its medicinal properties. Today, with the aid of advanced technologies like metabolomics and sophisticated analytical techniques, we have gained remarkable insights into the molecular-level changes induced by wine consumption in the human organism. This review embarks on a comprehensive exploration of the alterations in human metabolome associated with wine consumption. A great number of 51 studies from the last 25 years were reviewed; these studies systematically investigated shifts in metabolic profiles within blood, urine, and feces samples, encompassing both short-term and long-term studies of the consumption of wine and wine derivatives. Significant metabolic alterations were observed in a wide variety of metabolites belonging to different compound classes, such as phenolic compounds, lipids, organic acids, and amino acids, among others. Within these classes, both endogenous metabolites as well as diet-related metabolites that exhibited up-regulation or down-regulation following wine consumption were included. The up-regulation of short-chain fatty acids and the down-regulation of sphingomyelins after wine intake, as well as the up-regulation of gut microbial fermentation metabolites like vanillic and syringic acid are some of the most important findings reported in the reviewed literature. Our results confirm the intact passage of certain wine compounds, such as tartaric acid and other wine acids, to the human organism. In an era where the health effects of wine consumption are of growing interest, this review offers a holistic perspective on the metabolic underpinnings of this centuries-old tradition.
A Dynamic and Pseudo-Homogeneous MBs-icELISA for the Early Detection of Aflatoxin B1 in Food and Feed

Aflatoxin B1 (AFB1) is one of the most toxic and harmful fungal toxins to humans and animals, and the fundamental way to prevent its entry into humans is to detect its presence in advance. In this paper, the monoclonal antibody mAbA2-2 was obtained via three-step sample amplification and multi-concentration standard detection using a subcloning method based on the limited dilution method with AFB1 as the target. A dynamic and pseucdo-homogeneous magnetic beads enzyme-linked immunosorbent assay (MBs-icELISA) was established using the prepared antibody as the recognition element and immunomagnetic beads as the antigen carrier. The MBs-icELISA showed good linear correlation in the concentration range of 0.004–10 ng/mL with R2 = 0.99396. The limit of detection (LOD) of the MBs-icELISA for AFB1 was 0.0013 ng/mL. This new ELISA strategy significantly shortened AFB1 detection time through improved sensitivity compared to the conventional ELISA method.
Precision Medicine in Type 2 Diabetes Mellitus: Utility and Limitations

Abstract Type 2 diabetes mellitus (T2DM) is one of the most widespread diseases in Western countries, and its incidence is constantly increasing. Epidemiological studies have shown that in the next 20 years. The number of subjects affected by T2DM will double. In recent years, owing to the development and improvement in methods for studying the genome, several authors have evaluated the association between monogenic or polygenic genetic alterations and the development of metabolic diseases and complications. In addition, sedentary lifestyle and socio-economic and pandemic factors have a great impact on the habits of the population and have significantly contributed to the increase in the incidence of metabolic disorders, obesity, T2DM, metabolic syndrome, and liver steatosis. Moreover, patients with type 2 diabetes appear to respond to antihyperglycemic drugs. Only a minority of patients could be considered true non-responders. Thus, it appears clear that the main aim of precision medicine in T2DM is to identify patients who can benefit most from a specific drug class more than from the others. Precision medicine is a discipline that evaluates the applicability of genetic, lifestyle, and environmental factors to disease development. In particular, it evaluated whether these factors could affect the development of diseases and their complications, response to diet, lifestyle, and use of drugs. Thus, the objective is to find prevention models aimed at reducing the incidence of pathology and mortality and therapeutic personalized approaches, to obtain a greater probability of response and efficacy. This review aims to evaluate the applicability of precision medicine for T2DM, a healthcare burden in many countries.