Miracle-dz/UniFAR-FTUs huggingface dataset:
Standardization in the UV with Astrosat and its issues related to star cluster studies

Abstract The Ultra-Violet Imaging Telescope (UVIT) is one of the payloads in Astrosat, the first Indian Space Observatory. The UVIT instrument has two 375 mm telescopes: one for the far-ultraviolet (FUV) channel (1300-1800 Å), and the other for the near-ultraviolet (NUV) channel (2000-3000 Å) and the visible (VIS) channel (3200-5500 Å). We shall discuss the issues with standardization in the UV with reference to Astrosat Observations (Cycle A04). I shall discuss the problems faced in data-analysis and how these in turn lead to serious issues dealing with the color-magnitude diagarms, membership and age of the young embedded clusters studied.
The Nature of Space and Time

In these lectures Roger Penrose and I will put forward our related but rather different viewpoints on the nature of space and time. We shall speak alternately and shall give three lectures each, followed by a discussion on our different approaches. I should emphasize that these will be technical lectures. We shall assume a basic knowledge of general relativity and quantum theory. There is a short article by Richard Feynman describing his experiences at a conference on general relativity. I think it was the Warsaw conference in 1962. It commented very unfavorably on the general competence of the people there and the relevance of what they were doing. That general relativity soon acquired a much better reputation, and more interest, is in a considerable measure because of Roger’s work. Up to then, general relativity had been formulated as a messy set of partial differential equations in a single coordinate system. People were so pleased when they found a solution that they didn’t care that it probably had no physical significance. However, Roger brought in modern concepts like spinors and global methods. He was the first to show that one could discover general properties without solving the equations exactly. It was his first singularity theorem that introduced me to the study of causal structure and inspired my classical work on singularities and black holes. I think Roger and I pretty much agree on the classical work. However, we differ in our approach to quantum gravity and indeed to quantum theory itself. Although I’m regarded as a dangerous radical by particle physicists for proposing that there may be loss of quantum coherence I’m definitely a conservative compared to Roger. I take the positivist viewpoint that a physical theory is just a mathematical model and that it is meaningless to ask whether it corresponds to reality. All that one can ask is that its predictions should be in agreement with observation. I think Roger is a Platonist at heart but he must answer for himself. Although there have been suggestions that spacetime may have a discrete structure I see no reason to abandon the continuum theories that have been so successful. General relativity is a beautiful theory that agrees with every observation that has been made. It may require modifications on the Planck scale but I don’t think that will affect many of the predictions that can be obtained from it. It may be only a low energy approximation to some more fundemental theory, like string theory, but I think string theory has been over sold. First of all, it is not clear that general relativity, when combined with various other fields in a supergravity theory, can not give a sensible quantum theory. Reports of
Getting where you want to go

In 1956, referring to the emerging application of electron microscopy to the study of eukaryotic cells, Keith R. Porter wrote, “For those of us who are fortunate to be part of this new development, these are days of great interest and opportunity. ” Those early days left us a rich legacy of knowledge on the internal organization of eukaryotic cells that provides a framework for current research on cell structure and function. In this vein, my long-time quest has been to understand how proteins and organelles travel through the cytoplasm to reach their respective destinations within the cell. This research has led us to elucidate various mechanisms of protein sorting and organelle transport and how defects in these mechanisms cause human disease.
The potential energy landscape in the Lennard-Jones binary mixture model

The potential energy landscape in the Kob-Andersen Lennard-Jones binary mixture model has been studied carefully from the liquid down to the supercooled regime, from T = 2 down to 0.46. One thousand independent configurations along the time evolution locus have been examined at each temperature investigated. From the starting configuration, we searched for the nearest saddle (or quasi-saddle) and minimum of the potential energy. The vibrational densities of states for the starting and the two derived configurations have been evaluated. Besides the number of negative eigenvalues of the saddles other quantities show some signature of the approach of the dynamical arrest temperature.
Thermal X-Ray Line Emission from Accreting Black Holes

We present model X-ray spectra of accreting black holes with hot advection-dominated accretion flows, paying attention to thermal emission lines from the hot plasma. We discuss the emission-line diagnostics that are potentially observable with the next generation of X-ray observatories, emphasizing the possibilities for determining the outer radius of the hot plasma, the presence of a wind, and the relative importance of photoionization. We present example spectra of V404 Cyg in quiescence, the Galactic center black hole Sagittarius A*, and the nucleus of M87.
Casimir effect for arbitrary materials: contributions within and beyond the light cone

We obtain an expression for the Casimir force within a planar cavity without making particular models or assumptions about the nature of its walls. We obtain the energy and stress tensor in a closed ancillary system that has the same optical response as the target system, but that allows a fully quantum-mechanical treatment of the electromagnetic degrees of freedom. Our results constitute a generalization of the Lifshitz formula, applicable to a wide class of materials, which could be semi-infinite or finite, local or spatially dispersive, homogeneous or layered, dissipative or dissipationless. We discuss the incorporation of evanescent fields in the formalism, the electromagnetic normal modes of the system, its thermodynamic properties, and the generalization of our results to arbitrary geometries.
Risk factors and SCN5A-H558R polymorphism for atrial fibrillation in Tibetans living at different altitudes

Several studies have found associations of genes with atrial fibrillation (AF), including SCN5A-H558R. However, there are limited data of these associations among populations living at different altitudes. We investigated the relationship between the SCN5A-H558R polymorphism and AF in Tibetans living at different altitudes in Qinghai, China. General clinical and genotype data were obtained from 72 patients with AF and 109 non-AF (NAF) individuals at middle altitudes, and from 102 patients with AF and 143 NAF individuals at high altitudes. Multifactor logistic regression was performed to determine associations and AF risk factors. SCN5A-H558R genotypes differed significantly between the AF and NAF groups (P < .0125) and the G allele was an independent AF risk factor (P < .05) at both altitudes, with no significant differences according to altitude (P > .0125). At middle altitudes, age, red blood cell distribution width (RDW-SD), left atrial internal diameter (LAD), and G allele were independent AF risk factors. At high altitudes, age, smoking, hypertension, RDW-SD, free triiodothyronine, LAD, and G allele were independent AF risk factors (P < .05). The G allele of SCN5A-H558R might be an independent risk factor of AF both high and middle altitude, but there are some differences in other clinical risk factors of AF.
A conserved module in the formation of moss midribs and seed plant axillary meristems

Different evolutionary lineages have evolved distinct characteristic body plans and anatomical structures, but their origins are largely elusive. For example, seed plants evolve axillary meristems to enable lateral branching. In moss, the phyllid (leaf) midrib containing specialized cells is responsible for water conduction and support. Midribs function like vascular tissues in flowering plants but may have risen from a different evolutionary path. Here, we demonstrate that midrib formation in the model moss Physcomitrium patens is regulated by orthologs of Arabidopsis LATERAL SUPPRESSOR (LAS), a key regulator of axillary meristem initiation. Midribs are missing in loss-of-function mutants, and ectopic formation of midrib-like structures is induced in overexpression lines. Furthermore, the PpLAS/AtLAS genes have conserved functions in the promotion of cell division in both lineages, which alleviates phenotypes in both Physcomitrium and Arabidopsis las mutants. Our results show that a conserved regulatory module is reused in divergent developmental programs, water-conducting and supporting tissues in moss, and axillary meristem initiation in seed plants.
Theory, design, and experimental verification of a reflectionless bianisotropic Huygens' metasurface for wide-angle refraction.

Huygens' metasurfaces are electrically thin devices which allow arbitrary field transformations. Beam refraction is among the first demonstrations of realized metasurfaces. As previously shown for extreme-angle refraction, control over only the electric impedance and magnetic admittance of the Huygens' metasurface proved insufficient to produce the desired reflectionless field transformation. To maintain zero reflections for wide refraction angles, magnetoelectric coupling between the electric and magnetic response of the metasurface, leading to bianisotropy, can be introduced. In this paper, we report the theory, design, and experimental characterization of a reflectionless bianisotropic metasurface for extreme-angle refraction of a normally incident plane wave towards 71.8$^\circ$ at 20 GHz. The theory and design of three-layer asymmetric bianisotropic unit cells are discussed. The realized printed circuit board structure was tested via full-wave simulations as well as experimental characterization. To experimentally verify the prototype, two setups were used. A quasi-optical experiment was conducted to assess the specular reflections of the metasurface, while a far-field antenna measurement characterized its refraction nature. The measurements verify that the fabricated metasurface has negligible reflections and the majority of the scattered power is refracted to the desired Floquet mode. This provides an experimental demonstration of a reflectionless wide-angle refracting metasurface using a bianisotropic Huygens' metasurface at microwave frequencies.
Assessment of Oncology Patient Engagement and Interest in Virtual Mind-Body Programming: Moving Toward Personalization of Virtual Care

PURPOSE: Accelerated by the COVID-19 pandemic, the virtual platform has become a prominent medium to deliver mind-body therapies, but the extent to which patients engage in virtual mind-body programming remains unclear. This study aims to assess oncology patient engagement in a virtual mind-body program. METHODS: We surveyed oncology patients enrolled in a live-streamed (synchronous) virtual mind-body program in May 2021. Patients self-reported engagement by weekly attendance. We applied multivariate regression to identify associations of engagement with sociodemographic and clinical factors. As an exploratory analysis, we used machine learning to partition engagement subgroups to determine preferential interest in prerecorded (asynchronous) mind-body therapy videos. RESULTS: Among 148 patients surveyed (response rate: 21.4%), majority were female (94.5%), White (83.1%), age 65 years or older (64.9%), retired (64.2%), and in survivorship (61.8%). Patient engagement ranged from 1 to 13 classes/week (mean [standard deviation]: 4.23 [2.56]) and was higher for female (β, .82; 95% CI, 0.01 to 1.62), non-White (β, .63; 95% CI, 0.13 to 1.13), and retired patients (β, .50; 95% CI, 0.12 to 0.88). The partition model identified three engagement subgroups: employed (low engagers), retired White (intermediate engagers), and retired non-White (high engagers). Particularly, low engagers had preferential interest in meditation videos (odds ratio, 2.85; 95% CI, 1.24 to 6.54), and both low and high engagers had preferential interest in Tai Chi videos (odds ratio, 2.26; 95% CI, 1.06 to 4.82). CONCLUSION: In this cross-sectional study among oncology patients, engagement in virtual mind-body programming was higher for female, non-White, and retired patients. Our findings suggest the need for both synchronous and asynchronous mind-body programming to meet the diverse needs of oncology patients.
Symmetry breaking in a 3D bluff-body wake

The dynamics of a three-dimensional axisymmetric bluff-body wake are examined at low Reynolds regimes where transitions take place through spatio-temporal symmetry breaking. A linear stability analysis is employed to identify the critical Reynolds number associated with symmetry breaking, and the associated eigenmodes, known as global modes. The analysis shows that the axisymmetric stable base flow breaks the rotational symmetry through a pitchfork $m=1$ bifurcation, in agreement with previously reported results for axisymmetric wakes. Above this threshold, the stable base flow is steady and three-dimensional with planar symmetry. A three-dimensional global stability analysis around the steady reflectionally symmetric base flow, assuming no homogeneous directions, predicts accurately the Hopf bifurcation threshold, which leads to asymmetric vortex shedding. DNS simulations validate the stability results and characterize the flow topology during the early chaotic regime.
Gut microbiome in type 1 diabetes: the immunological perspective

ABSTRACT Introduction Type 1 diabetes (T1D) is a prevalent, and yet uncurable, autoimmune disease targeting insulin-producing pancreatic β-cells. Despite a known genetic component in T1D onset, genetics alone cannot explain the alarming worldwide rise in T1D incidence, which is attributed to a growing impact of environmental factors, including perturbations of the gut microbiome. Areas covered Intestinal commensal bacteria plays a crucial role in host physiology in health and disease by regulating endocrine and immune functions. An aberrant gut microbiome structure and metabolic function have been documented prior and during T1D onset. In this review, we summarize and discuss the current studies depicting the taxonomic profile and role of the gut microbial communities in murine models of T1D, diabetic patients and human interventional trials. Expert opinion Compelling evidence have shown that the intestinal microbiota is instrumental in driving differentiation and functions of immune cells. Therefore, any alterations in the intestinal microbiome composition or microbial metabolite production, particularly early in life, may impact disease susceptibility and amplify inflammatory responses and hence accelerate the course of T1D pathogenesis.
Identification, 16S rRNA–based characterization, and antimicrobial profile of Gallibacterium isolates from broiler and layer chickens

Gallibacterium spp. , particularly G. anatis, have received much attention as poultry pathogens in recent years. We report here the presence and antimicrobial resistance profile of 69 Gallibacterium isolates obtained from 2,204 diagnostic submissions of broiler and layer chickens in 2019–2021. Gallibacterium-positive chickens had lesions primarily in the respiratory tract, reproductive tract, and related serosal surfaces. Gallibacterium spp. were initially identified based on their typical cultural characteristics on blood agar. The isolates were confirmed by a genus-specific PCR spanning 16S-23S rRNA and MALDI-TOF mass spectrometry. Phylogenetic analysis based on 16S rRNA gene sequence revealed distinct clades. Of the 69 isolates, 68 clustered with the reference strains of G. anatis and 1 with Gallibacterium genomospecies 1 and 2. Antimicrobial susceptibility testing of 58 of the 69 isolates by a MIC method showed variable responses to antimicrobials. The isolates were all susceptible to enrofloxacin, ceftiofur, florfenicol, and gentamicin. There was a high level of susceptibility to trimethoprim–sulfamethoxazole (98.0%), streptomycin (98.0%), amoxicillin (84.0%), sulfadimethoxine (71.0%), and neomycin (71.0%). All of the isolates were resistant to tylosin. There was resistance to penicillin (98.0%), erythromycin (95.0%), clindamycin (94.0%), novobiocin (90.0%), tetracycline (88.0%), oxytetracycline (76.0%), and sulfathiazole (53.0%). A high rate of intermediate susceptibility was observed for spectinomycin (67.0%) and sulfathiazole (40.0%). Our findings indicate a potential role of G. anatis as an important poultry pathogen and cause of subsequent disease, alone or in combination with other pathogens. Continuous monitoring and an antimicrobial susceptibility assay are recommended for effective treatment and disease control.
Role of the mechanosensitive piezo1 channel in intervertebral disc degeneration

Intervertebral disc degeneration (IDD) is a multifactorial skeletal disease involving mechanical, genetic, systemic, and biological factors, and it is characterized by apoptosis of the nucleus pulposus cells and breakdown of the extracellular matrix (ECM), which will impair the structure and function of the intervertebral disc (IVD), and cause low back pain. Recently, the piezo1 is recognized as a critical mechanically activated ion channel of IDD. Numerous studies have reported that the piezo1 ion channel was aberrantly activated in the degenerated disc tissues and deeply participated in the pathogenesis of IDD. Inactivating or interfering with the piezo1 channel could effectively prevent the progression of IDD under the experimental conditions. It may be a promising target for the prevention and treatment of the disabling disease. Therefore, we have to make a comprehensive investigation and understanding of the mechanisms and functions of the piezo1 in the biomechanics of the spine. This study mainly elucidates the role of the piezo1 channel in IDD, which may facilitate the development of therapeutic targets for this disease.
Oseen Flow in Paint Marbling.

Paint marbling refers to techniques for creating intricate designs in colored paints floating on a liquid surface. If the marbling motions are executed slowly, then this layer of paints can be modeled as a two-dimensional incompressible Newtonian fluid. In this highly constrained model many marbling techniques can be exactly represented by closed form homeomorphisms. Homeomorphisms can be composed and compute the composite mapping at any resolution. Computing homeomorphisms directly is orders of magnitude faster than finite-element methods in solving paint marbling flows. Most marbling patterns involve drawing rakes from one side of the tank to the other; and these can be modeled by exact closed form homeomorphisms. But pictorial designs for flowers and animals use short strokes of a single stylus; presented is an exact velocity field for Oseen fluid flow and its application to creating short stroke marbling homeomorphisms.
Beliefs and barriers of COVID-19 vaccination hesitancy among Sudanese healthcare workers in Sudan: A cross sectional study

ABSTRACT Vaccine hesitancy is one of the major global health impedances. Due to the unprecedented developing rate, the COVID-19 vaccine engendered a high level of hesitancy worldwide. The aim of this study is to assess hesitancy of COVID-19 vaccine among healthcare workers in Sudan. An online-based cross-sectional survey was conducted in Sudan between May and June 2021 using conventional sampling. An anonymous online questionnaire was distributed to healthcare workers (HCW) through different social media platforms and 930 healthcare workers agreed to participate. Data were cleaned in excel sheet and then statistically analyzed using R software version 4.0. 2. Of total participants, 67.3% of them were females. Over three-fifths of the study participants agreed that COVID-19 vaccine is important and should be mandatory. A total of 570 (61.3%) agreed that COVID-19 vaccines are safe, whilst 584 (62.8%) had concerns regarding side effects of the vaccine and 533 (57.3%) believe insufficient trials were conducted. A total of 375 (40.3%) accept vaccination absolutely, while 292 (31.4%) accept with some hesitation and only 48 (5.2%) refuse absolutely. Insufficient information about side effects (42.6%) and the vaccine (39.9%) were the most common concerns regarding COVID-19 vaccination. Majority of Sudanese healthcare workers believed that COVID-19 vaccination should be mandatory. A high reliance on social media was observed among healthcare workers in Sudan for information on the COVID-19 pandemic.
Transition Propagation Graph Neural Networks for Temporal Networks

Researchers of temporal networks (e.g., social networks and transaction networks) have been interested in mining dynamic patterns of nodes from their diverse interactions. Inspired by recently powerful graph mining methods like skip-gram models and graph neural networks (GNNs), existing approaches focus on generating temporal node embeddings sequentially with nodes' sequential interactions. However, the sequential modeling of previous approaches cannot handles the transition structure between nodes' neighbors with limited memorization capacity. In detail, an effective method for the transition structures is required to both model nodes' personalized patterns adaptively and capture node dynamics accordingly. In this article, we propose a method, namely transition propagation graph neural networks (TIP-GNN), to tackle the challenges of encoding nodes' transition structures. The proposed TIP-GNN focuses on the bilevel graph structure in temporal networks: besides the explicit interaction graph, a node's sequential interactions can also be constructed as a transition graph. Based on the bilevel graph, TIP-GNN further encodes transition structures by multistep transition propagation and distills information from neighborhoods by a bilevel graph convolution. Experimental results over various temporal networks reveal the efficiency of our TIP-GNN, with at most 7.2% improvements of accuracy on temporal link prediction. Extensive ablation studies further verify the effectiveness and limitations of the transition propagation module. Our code is available at https://github.com/doujiang-zheng/TIP-GNN.
Instability of the rhodium magnetic moment as the origin of the metamagnetic phase transition in α-FeRh

Based on ab initio total energy calculations we show that two magnetic states of rhodium atoms together with competing ferromagnetic and antiferromagnetic exchange interactions are responsible for a temperature-induced metamagnetic phase transition, which is experimentally observed for stoichiometric $\ensuremath{\alpha}\ensuremath{-}\mathrm{FeRh}. $ Taking into account the results of previous and newly performed first-principles calculations we present a spin-based model, which allows us to reproduce this first-order metamagnetic transition by means of Monte Carlo simulations. Further inclusion of spacial variation of exchange parameters leads to a realistic description of the experimental magnetovolume effects in $\ensuremath{\alpha}\ensuremath{-}\mathrm{FeRh}. $