Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of alcohol on the symptoms of gouty arthritis and taxonomic structure of gut microbiota in C57BL/6 mice

Gout is an acute arthritis caused by the elevated levels of serum uric acid (UA), and its prevalence has been rapidly increasing. Alcohol abuse could lead to a series of health problems. Multiple pieces of evidence suggest that alcohol intake affects the development and progression of gout, while the gut microbiota plays an important role in the development of gout and the long-term alcohol consumption could affect the stability of the gut microbiota. This study aimed to explore the effects of alcohol intake at different concentrations on gouty arthritis based on the gut microbiota. We investigated the effects of different concentrations of alcohol on gouty arthritis in mouse models of acute gouty arthritis established by injection of monosodium urate (MSU) crystals into C57BL/6 mice. The results indicated that the high-alcohol consumption not only exacerbated joint swelling and pain, increased the levels of UA, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6), but also showed dramatic effects on the composition and structure of the gut microbiota in gouty mice. Two key microorganisms, Parasutterella and Alistipes, could aggravate gout symptoms through lipopolysaccharide biosynthesis, riboflavin metabolism, phenylalanine metabolism, and arginine and proline metabolisms. In conclusion, our study suggested that high-concentrations of alcohol altered the gut microbiota structure in gouty mice induced by MSU crystals, which could exacerbate gouty symptoms by enhancing pro-inflammatory pathways.
Cytomegalovirus Pneumonia in Inflammatory Bowel Disease: Literature Review and Clinical Recommendations

Aim The objective was to elucidate the correlation between CMVP and immunosuppressive therapy in IBD patients, we hope this review could expand on the significance of CMV as an opportunistic pathogen and the potential impact on morbidity and mortality in IBD patients. Methods Records and clinical trajectories linked to CMVP in IBD patients were extracted from the PubMed database, irrespective of language barriers. The reference lists incorporated in these studies were manually inspected. Conclusions were generated using straightforward descriptive analysis. Results In total, 18 IBD patients, including Crohn’s disease (CD, 67%) and Ulcerative Colitis (UC, 33%), affected by CMVP were identified from 17 published articles. A minority of these patients (17%) exhibited active disease, whereas the majority (83%) presented with quiescent disease. Fever (100%) and dyspnea (44%) emerged as the most prevalent clinical symptoms. All the patients had undergone immunosuppressive therapy. A significant proportion, up to 89%, had received thiopurine treatment prior to the CMVP diagnosis. Interestingly, none of the patients were subjected to biological therapy. Half of the patients manifested with Hemophagocytic Lymphohistiocytosis (HLH). Almost all patients (94%) were administered antiviral treatment and a substantial 83% experienced full recovery. Immunosuppressive agents were either tapered or discontinued altogether. A subset of patients, 17%, suffered fatal outcomes. Conclusion Our findings underscore the need for heightened suspicion of CMVP in IBD patients who exhibit symptoms such as fever and dyspnea. During the COVID-19 pandemic, CMVP should be considered a potential differential diagnosis. It was observed that CMVP primarily transpires during CD remission. Azathioprine emerged as the predominant immunosuppressant linked to CMV reactivation. The prompt application of effective antiviral therapy can substantially enhance patient outcomes. CMV vaccine might serve as a viable prevention strategy.
Postgraduate students online learning challenges during COVID-19 within the CoI framework context

Abstract The emergence of COVID-19 in 2020 forced the whole world to a standstill for a while, causing open and distance e-learning institutions like Unisa to adjust all teaching and learning activities and shift to online teaching entirely. This study explores the online learning challenges students in an open and distance e-learning environment in South Africa experienced during the COVID-19 pandemic, as guided by the Community of Inquiry framework. This qualitative content analysis study used thirty honours students’ responses to an open-ended question. Participants could share any thoughts on collaborative learning in an online environment. The key challenges identified by participants were the lack of teacher feedback, communication, online discussion, and interaction linked to teaching presence. The cognitive difficulties include complex modules, challenging questions, and a lack of detailed feedback. The social presence challenges indicated a lack of online support, virtual interaction, and online participation by teachers-to-students and student-to-peer-students. The study recommends the importance of teachers incorporating various facilitation strategies using the Community of Inquiry framework to create an effective online learning environment to assist students in studying remotely.
Role of growth differentiation factor 15 in cancer cachexia (Review)

Growth differentiation factor 15 (GDF15), a member of the transforming growth factor-β family, is a stress-induced cytokine. Under normal circumstances, the expression of GDF15 is low in most tissues. It is highly expressed during tissue injury, inflammation, oxidative stress and cancer. GDF15 has been established as a biomarker in patients with cancer, and is associated with cancer cachexia (CC) and poor survival. CC is a multifactorial metabolic disorder characterized by severe muscle and adipose tissue atrophy, loss of appetite, anemia and bone loss. Cachexia leads to reductions in quality of life and tolerance to anticancer therapy, and results in a poor prognosis in cancer patients. Dysregulated GDF15 levels have been discovered in patients with CC and animal models, where they have been found to be involved in anorexia and weight loss. Although studies have suggested that GDF15 mediates anorexia and weight loss in CC through its neuroreceptor, glial cell-lineage neurotrophic factor family receptor α-like, the effects of GDF15 on CC and the potential regulatory mechanisms require further elucidation. In the present review, the characteristics of GDF15 and its roles and molecular mechanisms in CC are elaborated. The targeting of GDF15 as a potential therapeutic strategy for CC is also discussed.
Isolation of Volatile Compounds by Microwave-Assisted Extraction from Six Veronica Species and Testing of Their Antiproliferative and Apoptotic Activities

This study was conducted to determine the differences in the chemical composition of the essential oils and hydrosols of six different Veronica species (V. agrestis, V. anagalloides, V. austriaca ssp. jacquinii, V. beccabunga, Veronica cymbalaria, and V. officinalis) and to test their antiproliferative and apoptotic activities, according to the authors’ knowledge, because of insufficient research and lack of information. Also, the goal was to determine which obtained samples were better in achieving antiproliferative and apoptotic activities and due to which volatile components. Therefore, essential oils (EOs) and hydrosols (HYs) were isolated from the above-mentioned Veronica species by microwave-assisted extraction (MAE). Phytochemical identification of the free volatile compounds was performed using a GC equipped with a flame ionization detector and a mass spectrometer. Their antiproliferative and apoptotic activities against two human cancer cell lines, breast cancer cell line MDA-MB-231 and bladder cancer cell line T24, were determined. The main compounds identified in the studied Veronica EOs and HYs were terpinen-4-ol (0.34–6.49%), linalool (0.34–6.61%), (E)-caryophyllene (0.97–7.55%), allo-aromadendrene (0.18–2.21%), caryophyllene oxide (1.42–23.83%), benzene acetaldehyde (0.26–13.34%), and β-ionone (1.08–16.53%). In general, HYs of the tested Veronica species showed higher antiproliferative activity (IC50 13.41–42.05%) compared to EOs (IC50 158.1–970.4 µg/mL) on MDA-MB-231 and T24 cancer cell lines after 48 and 72 h. V. agrestis EO showed the best apoptotic effect among the EOs on the MDA-MB-231 cancer cell line (10.47 ± 0.53% and 9.06 ± 0.74% of early/late apoptosis, compared with control 3.61 ± 0.62% and 0.80 ± 0.17% of early/late apoptosis, respectively) and among the HYs V. cymbalaria showed 9.95 ± 1.05% and 3.06 ± 0.28% of early/late apoptosis and V. anagalloides 8.29 ± 1.09% and 1.95 ± 0.36% of early/late apoptosis compared with control (for EO was 7.45 ± 1.01% and 0.54 ± 0.25%, and for HY was 4.91 ± 1.97% and 0.70 ± 0.09% of early/late apoptosis, respectively) on the T24 cancer cell line. Future research will include other Croatian species of the genus Veronica to gain a more complete insight into the biological activity of the volatile products of this genus for potential discovery of drugs based on natural plant extracts.
Analysis of the Christmas Storm Over Northern Italy

Between the 24th and the 26th of December 2013 Northern Italy was interested by heavy and diffuse precipitations events. The same stormy event, called "Christmas storm", interested all European area producing numerous damages and diseases especially in France and UK. The aim of the present research paper is to describe such meteorological event for Veneto and Trentino regions and to investigate if it has been exceptional or not compared with typical climate of the area. First of all, a definition of extreme events is proposed, followed by a meteorological description of the event. After that, the reported precipitation values are compared with long time series (about 30 years) of historical observed precipitation and temperature data. Finally, a detailed description of the soil impacts is reported.
Elevated CO2 reduced antimony toxicity in wheat plants by improving photosynthesis, soil microbial content, minerals, and redox status

Introduction Antimony (Sb), a common rare heavy metal, is naturally present in soils at low concentrations. However, it is increasingly used in industrial applications, which in turn, leads to an increased release into the environment, exerting a detrimental impact on plant growth. Thus, it is important to study Sb effects on plants under the current and future CO2 (eCO2). Methods To this end, high Sb concentrations (1500 mg/kg soil) effects under ambient (420 ppm) and eCO2 (710 ppm) on wheat growth, physiology (photosynthesis reactions) and biochemistry (minerals contents, redox state), were studied and soil microbial were evaluated. Results and discussion Our results showed that Sb uptake significantly decreased wheat growth by 42%. This reduction could be explained by the inhibition in photosynthesis rate, Rubisco activity, and photosynthetic pigments (Cha and Chb), by 35%, 44%, and 51%, respectively. Sb significantly reduced total bacterial and fungal count and increased phenolic and organic acids levels in the soil to decrease Sb uptake. Moreover, it induced oxidative markers, as indicated by the increased levels of H2O2 and MDA (1.96 and 2.8-fold compared to the control condition, respectively). To reduce this damage, antioxidant capacity (TAC), CAT, POX, and SOD enzymes activity were increased by 1.61, 2.2, 2.87, and 1.86-fold, respectively. In contrast, eCO2 mitigated growth inhibition in Sb-treated wheat. eCO2 and Sb coapplication mitigated the Sb harmful effect on growth by reducing Sb uptake and improving photosynthesis and Rubisco enzyme activity by 0.58, 1.57, and 1.4-fold compared to the corresponding Sb treatments, respectively. To reduce Sb uptake and improve mineral availability for plants, a high accumulation of phenolics level and organic acids in the soil was observed. eCO2 reduces Sb-induced oxidative damage by improving redox status. In conclusion, our study has provided valuable insights into the physiological and biochemical bases underlie the Sb-stress mitigating of eCO2 conditions. Furthermore, this is important step to define strategies to prevent its adverse effects of Sb on plants in the future.
Integrated Analysis of the Transcriptome and Metabolome of Brassica rapa Revealed Regulatory Mechanism under Heat Stress

Affected by global warming; heat stress is the main limiting factor for crop growth and development. Brassica rapa prefers cool weather, and heat stress has a significant negative impact on its growth, development, and metabolism. Understanding the regulatory patterns of heat–resistant and heat–sensitive varieties under heat stress can help deepen understanding of plant heat tolerance mechanisms. In this study, an integrative analysis of transcriptome and metabolome was performed on the heat–tolerant (‘WYM’) and heat–sensitive (‘AJH’) lines of Brassica rapa to reveal the regulatory networks correlated to heat tolerance and to identify key regulatory genes. Heat stress was applied to two Brassica rapa cultivars, and the leaves were analyzed at the transcriptional and metabolic levels. The results suggest that the heat shock protein (HSP) family, plant hormone transduction, chlorophyll degradation, photosynthetic pathway, and reactive oxygen species (ROS) metabolism play an outstanding role in the adaptation mechanism of plant heat tolerance. Our discovery lays the foundation for future breeding of horticultural crops for heat resistance.
Responses of Two-Row and Six-Row Barley Genotypes to Elevated Carbon Dioxide Concentration and Water Stress

Barley (Hordeum vulgare L.) is a crucial cereal crop globally, and its productivity is influenced by environmental factors, including elevated carbon dioxide (CO2) levels and water stress. The aim of this study is to investigate the effects of water stress and increased CO2 concentration on the growth, physiological responses, and yield of two-row and six-row barley genotypes. Univariate data analysis revealed significant effects of CO2 concentration on most traits except chlorophyll a (Chla), crop antioxidant capacity as evaluated by the activity of plant extracts to scavenge the 2,2-diphenyl-1-picrylhydrazyl (DPPH), and on the maximum quantum yield of photosystem II (Fv/Fm). Mean comparisons showed that elevated CO2 increased certain traits such as shoot dry weight (ShDW) (34.1%), root dry weight (RDW) (50.8%), leaf area (LA) (12.5%), grain weight (GW) (64.1%), and yield-related traits and combination of significant indices (CSI) (72.5%). In comparison, Proline (−19.3%), Malondialdehyde (MDA) (−34.4%) levels, and antioxidant enzyme activities, including ascorbate peroxidase (APX) (−39.1%), peroxidase (POX) (−26.1%), and catalase (CAT), (−34.4%) decreased. Water stress negatively affected ShDW (−40.2%), GW (−43.7%), RDW (−28.5%), and LA (−28.8%), while it positively affected DPPH (36.0%), APX (54.8%), CAT (85.1%), and MDA (101%). Six-row barley genotypes (Goharan and Mehr) had the highest yield under normal humidity and elevated CO2 concentrations, while under water stress conditions, their yield decreased more than two-row genotypes (Behrokh and M9316). Principal component analysis and heatmapping revealed that two-row barley genotypes exhibited the highest stress resistance under elevated CO2 concentrations, with the highest levels of secondary metabolites.
An overview of the aetiologic agents of diarrhoea diseases in children: How far have we gone in management and control?

Diarrhoea disease is the second leading cause of death amongst Nigerian children (after malaria) with a prevalence rate in Nigeria of 18.8% which is one of the worst in sub-Sahara Africa. A major contributor to childhood morbidity and mortality, causes 4 million deaths each year in under-fives with each child experiencing about 5 episodes of diarrhoea yearly. We review diarrhoea diseases in children with focus on infectious diarrhoea with the aim of looking at the progress made so far in its management and control. Diarrhoea can be classified into acute and chronic; secretory, osmotic, inflammatory or due to impaired motility; infectious and non-infectious. In developing countries, infections are the most common causes of acute watery diarrhoea in children, whereas chronic diarrhoea results from non-infectious causes like inherited metabolic disorders, sensitivity to gluten orneoplasm. Diagnosis includes a careful history from the patient, examination of stool sample and examination of faecal swab samples where stool is not available. Diarrhoea in this age group is mostly of infectious origin and can be viral, bacterial, parasitic or fungi. Treatment in this environment is primarily supportive with oral or intravenous fluid and preventive measures include domestic hygiene promotion, breast-feeding promotion, improved weaning practices, probiotic use, oral rehydration therapy with additional L-glutamine, zinc supplementation and vaccination against childhood infectious diseases like rotavirus, measles and cholera. An aluminmagnesium silicate, Smectite® has been found to be of potential benefit in the management of diarrhoea. Use of Rotavirus vaccines, probiotics and Smectite® is being advocated.
Improving prediction of computational job execution times with machine learning

Predicting resource consumption and run time of computational workloads is crucial for efficient resource allocation, or cost and energy optimization. In this paper, we evaluate various machine learning techniques to predict the execution time of computational jobs. For experiments we use datasets from two application areas: scientific workflow management and data processing in the ALICE experiment at CERN. We apply a two‐stage prediction method and evaluate its performance. Other evaluated aspects include: (1) comparing performance of global (per‐workflow) versus specialized (per‐job) models; (2) impact of prediction granularity in the first stage of the two‐stage method; (3) using various feature sets, feature selection, and feature importance analysis; (4) applying symbolic regression in addition to classical regressors. Our results provide new valuable insights on using machine learning techniques to predict the runtime behavior of computational jobs.
Candidate genes associated with heat stress and breeding strategies to relieve its effects in dairy cattle: a deeper insight into the genetic architecture and immune response to heat stress

The need for food products of animal origin is increasing worldwide. Satisfying these needs in a way that has minimal impact on the environment requires cutting-edge technologies and techniques to enhance the genetic quality of cattle. Heat stress (HS), in particular, is affecting dairy cattle with increasing frequency and severity. As future climatic challenges become more evident, identifying dairy cows that are more tolerant to HS will be important for breeding dairy herds that are better adapted to future environmental conditions and for supporting the sustainability of dairy farming. While research into the genetics of HS in the context of the effect of global warming on dairy cattle is gaining momentum, the specific genomic regions involved in heat tolerance are still not well documented. Advances in omics information, QTL mapping, transcriptome profiling and genome-wide association studies (GWAS) have identified genomic regions and variants associated with tolerance to HS. Such studies could provide deeper insights into the genetic basis for response to HS and make an important contribution to future breeding for heat tolerance, which will help to offset the adverse effects of HS in dairy cattle. Overall, there is a great interest in identifying candidate genes and the proportion of genetic variation associated with heat tolerance in dairy cattle, and this area of research is currently very active worldwide. This review provides comprehensive information pertaining to some of the notable recent studies on the genetic architecture of HS in dairy cattle, with particular emphasis on the identified candidate genes associated with heat tolerance in dairy cattle. Since effective breeding programs require optimal knowledge of the impaired immunity and associated health complications caused by HS, the underlying mechanisms by which HS modulates the immune response and renders animals susceptible to various health disorders are explained. In addition, future breeding strategies to relieve HS in dairy cattle and improve their welfare while maintaining milk production are discussed.
Vision-based Safe Maneuvers with Detection of 10cm Height Obstacles

An increasing number of new vehicles are being equipped with parking and backing-up assistant systems. Those systems both help the driver in conducting difficult maneuvers and in detecting the presence of obstacles to prevent collisions. The authors present a stereovision system that detects and monitors obstacles inside a 6m area in front or behind a vehicle. They use wide-angle cameras to detect side-appearing obstacles. The aim is at detecting pedestrian and cars, but also curbs, stopping blocks and small rocks which are ignored by most of other systems. This paper presents the low height obstacle (about 10cm) detection algorithm used in this system. The biggest challenge is to separate those obstacles from ground surface because the height variation with the ground is small and they correspond to very few pixels in the image (mainly with wide angle camera). The authors have developed a real-time wide angle stereo algorithm which detects obstacles in three stages: first, a plane that approximates the ground surface separates main obstacles such as pedestrians and cars from the ground. Second, a specific algorithm detects low height obstacles and small (10cm*10cm) objects by searching for small height transitions on the ground surface. Third, a free-space algorithm gathers information to compute the area where a vehicle can safely drive. The low height obstacle detection algorithm is the main contribution of the paper. The authors show detection results under typical urban situations and evaluate its detection rate. Drivable surface is correctly marked and low height obstacles are detected up to 6 meters.
The Effect of Service Communication Process and Customer Service Officer Complaint Handling on Satisfaction and Loyalty (Literature Review Marketing Management)

Article Literature Review of the Effect of Service Communication Process and handling complaints of customer service officers on customer satisfaction and loyalty of PT Bank Rakyat Indonesia (Persero) is a scientific article aimed at building research hypotheses of influence between variables that will be used in further research, within the scope of marketing management science. This Literature Review Article Writing Method is the Research Library Method, sourced from online media such as Google Scholar, Mendeley, and other academic online media. The results of the article literature article are 1) the service communication process affects satisfaction; 2) Handling of Customer Service Officer complaints affects satisfaction; 3) the Service communication process affects customer loyalty; 4) Handling of Customer Service Officer complaints affects customer loyalty, and 5) satisfaction affects customer loyalty. In addition to these two exogenous variables that affect the endogenous variable of customer satisfaction and loyalty, there are still many other factors, including brand reputation variables, strategic locations, commitment, and trust.