Miracle-dz/UniFAR-FTUs huggingface dataset:
Nuclear PLCs affect insulin secretion by targeting PPAR (cid:1) in pancreatic (cid:2) cells

Type 2 diabetes is a heterogeneous disorder caused by concomitant impairment of insulin secretion by pancreatic (cid:2) cells and of insulin action in peripheral target tissues. Studies with inhibitors and agonists established a role for PLC in the regulation of insulin secretion but did not distinguish between effects due to nuclear or cytoplasmic PLC signaling pathways that act in a distinct fashion. We report that in MIN6 (cid:2) cells, PLC (cid:2) 1 localized in both nucleus and cytoplasm, PLC (cid:3) 4 in the nucleus, and PLC (cid:1) 1 in the cytoplasm. By silencing each isoform, we observed that they all affected glucose-induced insulin release both at basal and high glucose concentrations. To elucidate the molecular basis of PLC regulation, we focused on peroxisome proliferator-activated receptor- (cid:1) (PPAR (cid:1) ), a nuclear receptor transcription factor that regulates genes critical to (cid:2) -cell maintenance and functions. of PLC (cid:2) 1 and PLC (cid:3) 4 resulted in a decrease in the PPAR (cid:1) mRNA level. By means of a PPAR (cid:1) -promoter-luciferase the could attributed to a PLC action on the PPAR (cid:1) -promoter region. the novel which internal control. When nuclear PLC (cid:1) 1 and PLC (cid:2) 4 were silenced, there was a decrease in PRE response. D ) Silenced ells were starved for 1 h in Krebs buffer with no glucose, and thereafter stimulated with 3 mM glucose for 1 h, and the medium was harvested. PPAR (cid:4) silencing resulted in a decreased insulin secretion, to a greater extent than PLC silencing. In all experiments, results the average of 3 independent experiments.
Absence of Escherichia coli O157:H7 Serotype in Small Indian Mongooses ( Herpestes auropunctatus ) in Grenada and Antimicrobial Drug Resistance of the non-O157 Isolates

Aim: To determine the occurrence of the E. coli including the O157:H7 serotype in mongooses and their antimicrobial drug resistance in Grenada . Study Design: Experimental based study of feces of mongooses captured from six parishes of Grenada from April 2011 to March 2013 during an active rabies surveillance program. Methodology: Fecal samples from 156 mongooses were cultured for E. coli and tested for O157:H7 serotype by the presence of non-sorbitol fermenting colonies and a positive reaction to Original Research Article Results: Of the 156 mongooses, 71 (46%) were culture positive for E. coli . A total of 213 E. coli isolates were recovered and examined for the presence of non-sorbitol fermenting colonies and O157-agglutination. Of the 213 E. coli isolates, only 8 (4%) were non-sorbitol fermenters. However, none of the 213 isolates gave a positive reaction (O157-agglutinating) to the two E. coli O157:H7 latex kits. Antimicrobial susceptibility tests against 12 drugs revealed a low resistance rates to ampicillin (8%), amoxicillin-clavulanic acid (0.5%), ciprofloxacin (1.4%), enrofloxacin (2.3%), gentamicin (0.5%), nalidixic acid (3.3%), and trimethoprim-sulfamethoxazole (5.6%). High resistance rates to streptomycin (38%) and tetracycline (36%) was observed among the E. coli isolates. The susceptibility rate to ampicillin, amoxicillin-clavulanic acid, cefotaxime, ceftazidime, ciprofloxacin, enrofloxacin, gentamicin, imipenem, nalidixic acid and trimethoprim-sulfamethoxazole ranged from 86.9 to 100%. Resistance to two or more antibiotics was observed in 57 (27%) of the E. coli isolates recovered. Conclusion: This study showed that presently, mongooses in Grenada are neither a reservoir for the E. coli O157:H7 serotype nor for multiple drug resistant E. coli strains. Among the 213 non-O157:H7 E. coli isolates, resistance drugs other streptomycin and tetracycline was very low.
Optical coherence tomography holds promise to transform the diagnostic anatomic pathology gross evaluation process

Abstract. Significance: Real-time histology can close a variety of gaps in tissue diagnostics. Currently, gross pathology analysis of excised tissue is dependent upon visual inspection and palpation to identify regions of interest for histopathological processing. Such analysis is limited by the variable correlation between macroscopic and microscopic findings. The current standard of care is costly, burdensome, and inefficient. Aim: We are the first to address this gap by introducing optical coherence tomography (OCT) to be integrated in real-time during the pathology grossing process. Approach: This is achieved by our high-resolution, ultrahigh-speed, large field-of-view OCT device designed for this clinical application. Results: We demonstrate the feasibility of imaging tissue sections from multiple human organs (breast, prostate, lung, and pancreas) in a clinical gross pathology setting without interrupting standard workflows. Conclusions: OCT-based real-time histology evaluation holds promise for addressing a gap that has been present for >100 years.
On Testing Modified Gravity : with Solar System Experiments and Gravitational Radiation

Three theories of gravitation – general relativity, the chameleon and Horava gravity - are confronted with experiment, using standard and adapted post-Newtonian (PN) tools. The laboratory is provided by the Solar System, binary pulsars and future detections at gravitational wave observatories. We test Horava gravity by studying emission of gravitational radiation in the weak-field limit for PN sources using techniques that take full advantage of the parametrized post-Newtonian (PPN) formalism. In particular, we provide a generalization of Einstein’s quadrupole formula and show that a monopole persists even in the limit in which the PPN parameters are identical to those of General Relativity. Based on a technique called non-relativistic General Relativity, we propose a phenomenological way to measure deviations from General Relativity coming from an unknown UV completion. Finally, we systematically show that the self-interacting chameleon at orders three and higher do not jeopardize the chameleon theory for Solar System type objects.
PPA_A_295383 1017..1026

1Department of Pharmacy, Tokyo Medical University Hospital, Tokyo, Japan; 2Department of Practical Pharmacy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan; 3Division of Biostatistics, Tohoku University Graduate School of Medicine, Miyagi, Japan; 4Department of Breast Surgery, Tokyo Medical University Hospital, Tokyo, Japan; 5Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan; 6Department of Emergency & Palliative Medicine, Faculty of Medicine, Saitama Medical University, Saitama, Japan Purpose: The importance of shared decision-making (SDM) between physicians and patients is increasingly recognized. In Japan, patients have shown more willingness to participate in treatment if medical professionals provide sufficient information; however, relationships between physicians and patients have traditionally been asymmetric, with patients accepting information from physicians without discussion. To explore the benefits of SDM in cancer treatment, including confidence in treatment decisions, satisfaction with treatment, and trust in healthcare providers, this study developed Japanese versions of the Control Preference Scale (CPS) and Information Needs Questionnaire (INQ). Patients and Methods: Reliability and validity of the CPS and INQ were tested with 49 breast cancer patients. Results: The CPS showed good test–retest reliability (kappa coefficient: 0.61, weighted kappa coefficient: 0.61, Kendall’s tau coefficient: 0.61) and acceptable criterion validity. The INQ showed adequate consistency; the mean number of circular triads and coefficient of consistency were 3 (range 0–19) and 0.9 (range 0.37–1), respectively. Using the CPS and INQ to identify patients’ roles in decision-making and information needs, results further suggested that breast cancer patients in Japan want to participate in SDM. Medical issues, including disease spread and cure, were found to be of high interest, while social and psychological issues, including sexual attractiveness, genetic risk, and family impact, tended to be low. Conclusion: The Japanese CPS and INQ can be used to assess patients’ needs to improve care. Further, as patients’ information needs change along the care trajectory, these tools should be used throughout treatment.
Morphology Control of MAPbI 3 Perovskite Thin Film as An Active Layer of Solar Cells

With one-step deposition, organic-inorganic perovskite solar cells with planar structure configuration can be produced. This technique has excellent potential for easy fabrication but it results in poor coverage of the film and thus affects the solar cells performance. In this research, morphology control was performed to improve the structure of the MAPbI 3 active layer by flowing hot air during one-step deposition. This allows the fabrication of simple, reproducible MAPbI 3 perovskite thin film with reduced pinhole formation. The hot airflow during the spin coating process homogeneously distributed grains of about 110 nm in size. A power conversion efficiency of 0.91 % was obtained with fill factor of 0.31 under a homemade sun simulator. The results indicate that hot airflow with reduced pinhole formation is a likely choice to control the morphology of thin film perovskite MAPbI 3 for solar cells.
Novel function of a dynein light chain in actin assembly during clathrin-mediated endocytosis

machinery necessary for normal internalization of native cargo in yeast. Tda2 has not been classified in any protein family. Unexpectedly, solving the crystal structure of Tda2 revealed it belongs to the dynein light chain family. However, Tda2 works independently of the dynein motor complex and microtubules. Tda2 forms a tight complex with the polyproline motif–rich protein Aim21, which interacts physically with the SH3 domain of the Arp2/3 complex regulator Bbc1. The Tda2–Aim21 complex localizes to endocytic sites in a Bbc1- and filamentous actin–dependent manner. Importantly, the Tda2–Aim21 complex interacts directly with and facilitates the recruitment of actin-capping protein, revealing barbed-end filament capping at endocytic sites to be a regulated event. Thus, we have uncovered a new layer of regulation of the actin cytoskeleton by a member of a conserved protein family that has not been previously associated with a function in endocytosis.
Consiglio Nazionale delle Ricerche Fake accounts detection on Twitter

Fake followers are those Twitter accounts created to inﬂate the number of followers of a target account. Fake followers are dangerous to the social platform and beyond, since they may alter concepts like popularity and inﬂuence in the Twittersphere—hence impacting on economy, politics, and Society. In this paper, we provide several contributions. First, we review the most relevant existing criteria (proposed by Academia and Media) for anomalous Twitter accounts detection, and later we assess their capability to detect fake followers. In particular, we contribute with the creation of a gold standard of veriﬁed human, as well as with a set of known fake accounts. We test the above cited criteria against these two data sets, showing that the analyzed mechanisms provide unsatisfactory performance in revealing fake followers. Moreover, building upon these results, we also introduce a novel taxonomy to discriminate fake followers from legitimate ones and spammers. The ﬁndings reported in this paper, other than being supported by a thorough experimental methodology and being interesting on their own, also pave the way for further investigation.
Nonlinear MDOF system characterization and identi cation using the Hilbert-Huang transform

The Hilbert transform is one of the most successful approaches to tracking the varying nature of vibration of a large class of nonlinear systems thanks to the extraction of backbone curves from experimental data. Because signals with multiple frequency components do not admit a well-behaved Hilbert transform, it is inherently limited to the analysis of single-degree-of-freedom systems. In this study, the joint application of the complexification-averaging method and the empirical mode decomposition enables us to develop a new technique, the slow-flow model identification method. Through numerical and experimental applications, we demonstrate that the proposed method is adequate for characterizing and identifying multi-degree-offreedom nonlinear systems.
Towards a Policy-Framework for the Deployment and Management of Cloud Services

—As the adoption of Cloud Computing is growing, the automated deployment of cloud-based systems is becoming more and more important. New standards, such as TOSCA (OASIS), allow the modeling of interoperable Cloud services. It is now possible to build reusable and portable cloud services that can be (semi-) automatically deployed by different cloud-deployment-engines at various Cloud environments. However, there is still an acceptance problem among potential users, especially in the enterprise segment, that stems from security issues like data security. To improve security in automatic Cloud management engines, this paper proposes a framework for processing non-functional requirements of Cloud services.
A new approach of 2D discrete cosine transform with Mobius inverse formula

The 2D discrete cosine transform (DCT) is an important mathematical tool in digital image processing and many other fields. Our aim is mainly to present an algorithm of 2D DCT, which turns N/spl times/N DCT into N separate 1D DCT and addition operations, and then to implement DCT with an arithmetic Fourier transform (AFT), which has turned out to be an important alternative to the known traditional methods of fast Fourier transform (FFT) in terms of accuracy, complexity and speed. The total number of multiplications and additions is only half of that required for the corresponding traditional method. Simulation results show that this method is feasible and its computational complexity is lower than the row-column algorithm.
The Eﬀects of Frankincense on Oral Squamous Cell Carcinoma Cell Line

Background: Cytotoxic eﬀects of Frankincense resin have been shown on some cancer cell lines. Due to its low side eﬀects, this studywasdesignedtoevaluatetheanticancerpropertiesof watersolubleelementsof Frankincenseoleo-gum-resinonhumanoral squamous cell carcinoma cell line. Methods: Oleo-gum-resin was macerated in ethanol. After ﬁltration, the water soluble fraction of dried residue was extracted. KB cells were treated with 0, 62.5, 125, 250 and 500 µ g/mL concentrations of obtained Frankincense aqueous fractions and with Dox-orubicinaspositivecontrol. Frankincenseinducedcellcytotoxicity; apoptosisandproliferationwereinvestigatedusingWSTassay, Annexin V-FITC/PI, and Ki-67 staining, respectively. Data were analyzed using Kruskal-Wallis test by SPSS 17 software. Results: IC 50 of 137.21 µ g/mLwasobtainedfromFrankincenseaqueousfractionafter48hours. Thepercentageof apoptoticcellswas elevatedinatime-anddose-dependentmanner. TherewasnostatisticaldiﬀerenceintheKi-67expressionof KBcells,usingdiﬀerent concentration of Frankincense aqueous fraction after 24 and 48 hours (P = 0.083). Doxorubicin inhibited cells growth essentially through apoptosis. Conclusions: Frankincense aqueous fractions seem to suppress KB cell growth through the induction of apoptosis and necrosis rather than the inhibition of proliferation and hence might be a potential anticancer agent. Structural analysis and puriﬁcation of potent components are suggested for determining more deﬁnitive results.
Socio-demographic Characteristics and Client Care Satisfaction among Older-Adult Admitted in The Two Tertiary Hospitals in Osun State, Nigeria

The study investigated socio-demographic characteristics and client care satisfaction among older- adult admitted in the two tertiary hospitals in Osun state, Nigeria. The study specifically examined the relationship between caring behaviour of nurses and clients’ care satisfaction; and the effect of socio- demographic characteristics on clients’ care satisfaction. The study employed a descriptive research design using two hypotheses. The population for the study were older adults admitted in the two tertiary hospitals in Osun State. A total number of one hundred and seventy-seven (177) respondents were selected from the two hospitals. A self-developed questionnaire was used to elicit information from the respondents. The face and content validity of the instrument was validated by experts in the field of Tests & Measurement. Reliability of the instrument was ascertained through Cronbach’s Alpha and Cronbach’s alpha value of 0.802 was gotten . Inferential statistics of Pearson Product Moment Correlation Statistics and Chi-square were used to analyse the two stated hypotheses at 0.05 level of significance. The findings of the study revealed that the caring behaviour of nurses was positively related to patients care satisfaction while socio-demographic characteristics such as gender, period of admission and age were correlates of patients care satisfaction. It was recommended among others that Nurses should be more active in patients’ care by developing active listening skills and sensitive to patients' needs.
Depression Detection using speech as Input Signal

In this paper we propose a method for computer based depression detection. It is focusing on two aspects: gathering conversations and getting only the patient’s audio and creating a deep learning model for automatic depression detection. Convolutional Neural Network (CNN) classifier is used to find patterns in audio characteristics of the depressed patients. This training is carried out on DAIC-WOZ Dataset from USC’s Institute of Creative Technologies and it was released as part of the AVEC(Audio/Visual Emotional Challenge) 2016. There is a sample imbalance in the dataset, as there are more number of non-depressed patients in the dataset. To remove this sample imbalance, we introduce random sampling before the model training.
Minimal Parameter Homotopies for the L2 Optimal Model Order Reduction Problem

The problem of finding a reduced order model, optimal in the L2 sense, to a given system model is a fundamental one in control system analysis and design. The problem is very difficult without the global convergence of homotopy methods, and a number of homotopy based approaches have been proposed. The issues are the number of degrees of freedom, the well posedness of the finite dimensional optimization problem, and the numerical robustness of the resulting homotopy algorithm. Homotopy algorithms based on several formulations are developed and compared here. The main conclusions are that dimensionality is inversely related to numerical well conditioning and algorithmic efficiency is inversely related to robustness of the algorithm.
Keratins in Skin Epidermal Development and Diseases Keratins in Skin Epidermal Development and Diseases

Epidermal keratinocyte (KC), the major cell type in the skin epidermis, plays critical roles in forming a permeability barrier to separate internal organs from external stimuli. Keratins, constituting about 30 – 80% of the total protein in KCs, form the major intermediate filament cytoskeleton of KC. Keratins consist of 54 unique genes in humans and they are expressed in cell-, differentiation- and development-dependent manner. While keratin pairs K5-K14 and K1-K10 are normally associated with KCs at different cell differentiation stages, other keratin pairs such as K6-K16/K17 and K8 – K18 and are usually not expressed in normal skin interfollicular epidermis, but are elevated during wounding, inflammatory skin diseases such as psoriasis or malignant conversion of KC. The expression and function of keratins are tightly regulated at both transcriptional and post-transcriptional levels. Inherited or spontaneous mutations in keratins or abnormal keratin regulations or modifications can cause KC and cutaneous tissue fragility, skin hypertrophic and inflammatory conditions or malignant transformation of KC, therefore accounting for a large number of disorders in human skin. Here we review the recent literature on how keratins are nor- mally expressed during skin development and how mutations or misregulations of these keratins are involved in the pathogenesis of skin diseases. and epidermal blistering. Autosomal mutations of the suprabasal KC markers K10 and K1 are associated with hyperkeratosis skin disease “ Epidermolytic/Bullous ichthyosis ” and are caused by an increase in suprabasal cell fragility/blistering, inflammation, proliferation of basal cells and hyperkeratosis of epithelium. In skin wounds, inflammatory skin diseases such as psoriasis, or squamous cell carcinomas (SCCs), suprabasal cells express high levels of K6, K16 and K17 (keratins associated with activated KC), and these keratins decrease KC adhesion and differentiation and promote immune cell activation and KC proliferation. K8/K18 expression is found in poorly differentiated SCCs with increased invasiveness. K8 or K18 expression in KC leads to decreased cell – cell contact and an increase protection against apoptosis, as well as invasiveness and malignant transformation potential of KC.
study of co-authorship in Translation Studies

The main aims of this article are, on the one hand, to gain a better understanding of co-authorship practices in Translation Studies (TS) by examining how they have evolved over time and, on the other, to find out whether there is a citation advantage for co-authored works. Most of the data used for this study have been retrieved from BITRA (Bibliography of Interpreting and Translation), containing over 69,000 TS records. The analysis covering 54 years has focused on parameters including the percentage of co-authored documents versus single-authored, co-authored contributions by document type, evolution of co-authorship over time, mean number of authors per contribution, citations of co-authored vs. single-authored documents, or the ratio of international cooperation in TS. In order to complement the bibliometric analysis, we also weigh up the advantages and disadvantages of co-authorship taking a more qualitative approach. Our data yield the following interesting results. Firstly, the number of co-authored documents and the number of citations accrued by co-authored documents are on the increase. Secondly, there is a slight co-authorship citation advantage in the case of journal articles. Thirdly, the average number of authors is nowadays higher in TS as compared with other disciplines in Humanities. Fourthly, the ratio of international collaboration is rather poor, below 10%. Our findings represent an initial insight into the evolution and current situation of co-authorship in TS, and hopefully it might prove inspiring and a valuable starting point not only for future research, but also for research assessment policies that should be permeable to new trends in publication patterns in TS.
Estimation of Naringenin in Salacia reticulata Wight, Fishing Targets and Harmonizing the Ligand for Type 2 Diabetes

Type 2 diabetes mellitus is characterized by insulin resistance and hyperglycemia and accounts for 90 per cent of diabetes cases. Salacia reticulata Wight, a climbing shrub indigenous to India and Sri Lanka, is an important source of anti-diabetic compounds. In this study, the abundance of naringenin was estimated in various tissues of the plant using RP-HPLC. The highest concentration of naringenin was found in fresh and dried roots at 3.4 and 3.2 %, respectively. Through in silico analysis affinity of naringenin to PPAR-γ, 11β-Hydroxysteroid-Dehydrogenase I, PPAR-α, PPAR-δ and Glycogen Synthase Kinase - 3β, the targets for type 2 diabetes mellitus drug targets were -8.7, -8.4, -7.1, -8.4 and -7.8 kcal/mol, respectively.