Miracle-dz/UniFAR-FTUs huggingface dataset:
Causes of HIV Treatment Interruption during the Last 20 Years: A Multi-Cohort Real-Life Study

In the last years, many antiretroviral drugs (ART) have been developed with increased efficacy. Nowadays, the main reasons for treatment switches are adverse events, proactive strategy or simplification. We conducted a retrospective cohort study to investigate the reason for treatment interruption in the last 20 years. We merged data of eight cohorts of the SCOLTA project: lopinavir/r (LPV), atazanavir/r (ATV), darunavir/r or /c (DRV), rilpivirine (RPV), raltegravir (RAL), elvitegravir/c (EVG), dolutegravir (DTG) and bictegravir (BIC). We included 4405 people with HIV (PWH). Overall, 664 (15.1%), 489 (11.1%), and 271 (6.2%) PWH interrupted the treatment in the first, second, and third years after starting a new ART. Looking at the interruption in the first year, the most frequent causes were adverse events (3.8%), loss to follow-up (3.7%), patients’ decisions (2.6%), treatment failure (1.7%), and simplification (1.3%). In the multivariate analysis regarding experienced patients, treatment with LPV, ATV, RPV or EVG/c, having less than 250 CD4 cells/mL, history of intravenous drug use, and HCV positivity were associated with an increased risk of interruption. In naive people, only LPV/r was associated with an increased risk of interruption, while RPV was associated with a lower risk. In conclusion, our data on more than 4400 PWH show that adverse events have represented the most frequent cause of treatment interruptions in the first year of ART (3.84%). Treatment discontinuations were more frequent during the first year of follow-up and decreased thereafter. First-generation PI in both naïve and experienced PWH, and EVG/c, in experienced PWH, were associated with a higher risk of treatment interruptions.
Quantification of rice canopy nitrogen balance index with digital imagery from unmanned aerial vehicle

With the rise of large-scale crop plantation in China, inexpensive but efficient remote-sensing measures for predicting the nitrogen status of crops are needed for optimal fertilizer management. In this research, a conventional digital camera with a charge coupled device was integrated into an unmanned aerial vehicle (UAV) to capture digital aerial images of paddy rice (Oryza sativa L.) at an altitude of 50 m. The fluorescence emissions of the rice leaves under light excitation were used by Multiplex® to non-destructively assess the chlorophyll and polyphenol content. The nitrogen balance index (NBI) of the rice leaves, known as the ratio of chlorophyll to polyphenols, was used to accurately determine canopy nitrogen concentrations. The dark green colour index (DGCI) available from the aerial images was used to assess the nitrogen concentrations in the field. It was found that DGCI values predicted the nitrogen concentrations and NBI with R2 (coefficient of determination) = 0.672 (p < 0.001) and R2 = 0.711 (p < 0.001), respectively. The results indicated that aerial photography from UAV had the ability to assess plant nitrogen status in the field in large-scale crop plantations.
Multilateral Climate Finance Coordination: Politics and Depoliticization in Practice

Abstract The governance of public climate finance for mitigation and adaptation in developing countries is fragmented on both the international and national levels, with a high diversity of actors with overlapping mandates, preferences, and areas of expertise. In the absence of one unifying actor or institution, coordination among actors has emerged as a response to this fragmentation. In this article, we study the coordination efforts of the two most important multilateral climate funds, the Climate Investment Funds (CIF) and the Green Climate Fund (GCF), on the global level as well as within two recipient countries, Kenya and Zambia. The CIF and the GCF are anchored within the World Bank and the United Nations Framework Convention on Climate Change, respectively, and represent two diverging perspectives on climate finance. We find that on both levels, coordination was depoliticized by treating it as a technical exercise, rendering invisible the political divergences among actors. The implications of this depoliticization are that both funds coordinate mainly with actors with similar preferences, and consequently, coordination did not achieve its objectives. The article contributes to the literatures on coordination, climate finance, and environmental governance by showing how a response to the fragmentation of climate governance did not overcome political fault lines but rather reinforced them.
Pretreatment with Eupatilin Attenuates Inflammation and Coagulation in Sepsis by Suppressing JAK2/STAT3 Signaling Pathway

Purpose Sepsis is an aggressive and life-threatening organ dysfunction induced by infection. Excessive inflammation and coagulation contribute to the negative outcomes for sepsis, resulting in high morbidity and mortality. In this study, we explored whether Eupatilin could alleviate lung injury, reduce inflammation and coagulation during sepsis. Methods We constructed an in vitro sepsis model by stimulating RAW264.7 cells with 1 μg/mL lipopolysaccharide (LPS) for 6 hours. The cells were divided into control group, LPS group, LPS+ Eupatilin (Eup) group, and Eup group to detect their cell activity and inflammatory cytokines and coagulation factor levels. Cells in LPS+Eup and Eup group were pretreated with Eupatilin (10μM) for 2 hours. In vivo, mice were divided into sham operation group, cecal ligation and puncture (CLP) group and Eup group. Mice in the CLP and Eup groups were pretreated with Eupatilin (10mg/kg) for 2 hours by gavage. Lung tissue and plasma were collected and inflammatory cytokines, coagulation factors and signaling were measured. Results In vitro, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and tissue factor (TF) expression in LPS-stimulated RAW264.7 cells was downregulated by Eupatilin (10μM). Furthermore, Eupatilin inhibited phosphorylation of the JAK2/STAT3 signaling pathway and suppressed p-STAT3 nuclear translocation. In vivo, Eupatilin increased the survival rate of the mice. In septic mice, plasma concentrations of TNF-α, IL-1β and IL-6, as well as TF, plasminogen activator inhibitor 1 (PAI-1), D-dimer, thrombin-antithrombin complex (TAT) and fibrinogen were improved by Eupatilin. Moreover, Eupatilin alleviated lung injury by improving the expression of inflammatory cytokines and TF, fibrin deposition and macrophage infiltration in lung tissue. Conclusion Our results revealed that Eupatilin may modulate inflammation and coagulation indicators as well as improve lung injury in sepsis via the JAK2/STAT3 signaling pathway.
The Effect of Plant-Based and Mycoprotein-Based Meat Substitute Consumption on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis of Controlled Intervention Trials

Background: Climate change is a serious threat to human wellbeing and development. Global reduction of meat intake is key to addressing climate change and other modern sustainability challenges. Plant-based and mycoprotein-based meat substitutes are predicted to play a key role in the reduction of meat intake; however, their impact on human health is unclear. The main objective of this meta-analysis was to assess the short-term effects of meat substitutes on important cardiometabolic biomarkers (total cholesterol, TC; LDL-cholesterol, LDL-C; HDL-cholesterol, HDL-C; triglycerides, TG; systolic blood pressure, SBP; diastolic blood pressure, DBP; fasting blood glucose, FBG; weight) in controlled clinical trials. Methods: Embase and MEDLINE were searched to identify controlled clinical trials with meat substitute interventions and cardiometabolic biomarker outcomes. Standardised mean differences in TC, LDL-C, HDL-C, TG, FBG, SBP, DBP, and weight and 95% confidence intervals were pooled using a random effects model. Risk of bias, heterogeneity, sensitivity, and publication bias were assessed. Of the 934 records identified, 12 studies met the inclusion criteria. In the pooled analyses, the consumption of meat substitutes was associated with significantly lower TC (−0.50 mmol/L [95% CIs −0.70, −0.29]), LDL-C (−0.39 mmol/L [−0.57, −0.21]), and TG (−0.15 mmol/L [−0.29, −0.01]), non-significantly lower FBG (−0.08 [−0.23, 0.08]), SBP (−0.32 [−1.79, 1.41]), and weight (−0.12 [−1.52, 1.27]), and non-significantly higher HDL-C (0.01 [−0.02, 0.05]) and DBP (0.49 [−0.30, 1.28]). There was evidence of publication bias, and some heterogeneity was detected. The certainty of evidence was moderate for the TC and HDL-C results, low for the LDL-C, TG, SBP, DBP, and weight results, and very low for the FBG results. Conclusions: Replacement of some or all meat with plant-based or mycoprotein-based substitutes may lower TC, LDL-C, and TG.
MATLAB-Simulink environment based power quality improvement in photovoltaic system using multilevel inverter

Introduction. In this world of technical advancement, conventional resources are at the stage of destruction. To avoid such problems, we are going to use an alternative energy source namely solar by photovoltaic effect. The demand for multilevel inverters increased as they are used for different dynamic (high) voltage and dynamic (high) power appliances as they are capable of producing the output wave shape with low total harmonic distortion. Novelty. A new multilevel inverter is used in adding a (bidirectional) two way switch in between the capacitor and a traditional H-bridge module. This produces a better sine wave. By series connection of these two H-bridge modules, nine levels output voltage including zero is possible. The purpose of the proposed topology is reduction in the number of switches and it gives the good result with comparatively less power loss when it is compared with the other normal basic traditional inverters of the same output quality. Methods. In this paper, sinusoidal pulse width modulation technique is used for the working of the switches in the multilevel inverter. The results are verified by using simulation and also experimental setup is done. From the results it is observed that the proposed topology with reduced number of switches gives lower electromagnetic interference, lower harmonic distortion. Practical value. The total harmonic distortion value in the simulation is 14.4 % and practically it is 13.8 %.
Dysregulation of circRNA-0076906 and circRNA-0134944 is Correlated with Susceptibility to Osteoporosis and Osteoporotic Fracture in Postmenopausal Females from the Chinese Han Population

Introduction Many circRNAs, such as circRNA-0076906 and circRNA-0134944, have been reported to participate in the pathogenesis of osteoporosis via sponging miRNAs in postmenopausal female patients. In this study, we aimed to study potential signaling pathways underlying the role of certain circRNAs, miRNAs and their target genes in the pathogenesis of osteoporotic fracture in postmenopausal females. Methods Quantitative real-time PCR was performed to analyze the expression of circRNAs, miRNAs and their targets genes. Luciferase assays were carried out to explore the regulatory relationship between circ_0076906/miR-548i/OGN and circ_0134944/miR-630/TLR4. Results Osteoporosis and fracture were positively correlated to the expression of circ_0134944, miR-548i and TLR4, but negatively correlated to the expression of circ_0076906, miR-630 and OGN in the peripheral blood and bone tissue samples of postmenopausal women. Luciferase activities of wild-type circ_0076906 and OGN were inhibited by miR-548i, and the luciferase activities of wild-type circ_0134944 and TLR4 were suppressed by miR-630 in MG-63 and U-2 OS cells. Inhibition of circ_0076906 expression in MG-63 and U-2 OS cells activated the expression of miR-548i and inhibited the expression of OGN. Moreover, the overexpression of circ_0134944 in MG-63 and U-2 OS cells suppressed the expression of miR-630 and enhanced the expression of TLR4. Conclusion This study implied that the dysregulation of circRNA-0076906 and circRNA-0134944 modulated their specific signaling and thus contributed to the severity of osteoporosis, increasing the risk of osteoporotic fracture.
Development and validation of a prognostic nomogram for neuroendocrine prostate cancer, based on the SEER database

Background The tumor biology of neuroendocrine prostate cancer (NEPC) is different from that of ordinary prostate cancer, herefore, existing clinical prognosis models for prostate cancer patients are unsuitable for NEPC. The specialized individual situation assessment and clinical decision-making tools for NEPC patients are urgently needed. This study aimed to develop a valid NEPC prognostic nomogram and risk stratification model to predict risk associated with patient outcomes. Methods We collected 340 de-novo NEPC patients from the SEER database, and randomly selected 240 of them as the training set and the remaining 100 as the validation set. Cox regression model was used to screen for risk factors affecting overall survival (OS) and cancer-specific survival (CSS) and construct a corresponding nomogram. The receiver operating characteristic (ROC) curves, calibration curves, C-indexes, and decision curve analysis (DCA) curves are used to verify and calibrate nomograms. Results NEPC prognosis nomograms were constructed by integrating independent risk factors. The C-indexes, ROC curves, calibration curves, and DCA curves revealed excellent prediction accuracy of the prognostic nomogram. Furthermore, we demonstrated that NEPC patients in the high-risk group had significantly lower OS and CSS than those in the low-risk group with risk scores calculated from nomograms. Conclusions The nomogram established in this research has the potential to be applied to the clinic to evaluate the prognosis of NEPC patients and support corresponding clinical decision-making.
Qualitative theory of the nonlinear behavior of coupled Josephson junctions

We use qualitative mathematical methods for the analysis of the time dependence of the phase differences and, hence, the dynamic I‐V characteristics for two coupled Josephson point junctions. All our qualitative results are supported by numerical calculations. The case of a single point junction is reviewed and extended; it is proved that periodic trajectories in the phase plane are attractors and that they are therefore unique for a given junction and dc driving current I. Center of mass and relative coordinates are introduced for two inductively coupled junctions and the latter coordinate is shown to remain bounded. All static solutions are obtained and their stabilities analyzed. We find that the end of stability of a given solution is never a Hopf bifurcation and, hence, is marked by a finite jump to a dynamic or another static solution. The dynamic solutions are analyzed using perturbation theory for strongly coupled junctions. An approximation for the beating mode in weakly coupled junctions is pres.
The Development of New Agents for Post-Hematopoietic Stem Cell Transplantation Non-Infectious Complications in Children

Hematopoietic stem cell transplantation (HSCT) is often the only curative treatment option for patients suffering from various types of malignant diseases and some non-cancerous conditions. Nevertheless, it is associated with a high risk of complications leading to transplant-related mortality and long-term morbidity. An increasing number of therapeutic and prevention strategies have been developed over the last few years to tackle the complications arising in patients receiving an HSCT. These strategies have been mainly carried out in adults and some are now being translated into children. In this manuscript, we review the recent advancements in the development and implementation of treatment options for post-HSCT non-infectious complications in pediatric patients with leukemia and other non-malignant conditions, with a special attention on the new agents available within clinical trials. We focused on the following conditions: graft failure, prevention of relapse and early interventions after detection of minimal residual disease positivity following HSCT in acute lymphoblastic and myeloid leukemia, chronic graft versus host disease, non-infectious pulmonary complications, and complications of endothelial origin.
Infant Responding Under Conjugate vs.Continuous Reinforcemen

The peiformance of six human infants (aged 16 to 20 weeks) was compared under a conjugateversus a continuousreinforcement schedule. The contingent visual stimulus, a sequence of 5 colored lights, their intensity varying in proportion to response amplitude under the conjugate but not under the continuous schedule, was presented alone and together with a constant auditory contingent stimulus-ehimes placed behind the lights-under both schedules. The target operant response-a foot press of a vertical panel-produced the lights with/without the tinkling chimes. A reversal design counterbalanced with alternating treatments was implemented for each half of the participants. Visual inspection of the graphedoperant frequencies for all six infants, and one-tail binomial tests, showed at p < 0.008 that: (a) the two contingent-stimulus complexes, visual alone and visual-plus auditory, functioned as reinforcers of leg thrusts under both reinforcement schedules; the visual-pIus-auditory consequence was a more effective reinforcer for leg-thrust operants than was the visual consequence alone; and, (c) compared to the continuous CRF schedule, the conjugate-reinforcement schedule generated higher peak responding.
Nanosize fabrication using etching of phase-change recording films

An etching technique called phase-change etching was developed. In this technique, only crystalline regions in a phase-change recording film are selectively etched by an alkaline solution, and amorphous regions remain on the sample surface, which means that a phase-change recording film can be used as a resist for pattern formation. By combination of this technique and phase-change recording, fabrication of the dot pattern with a size of about 1∕10 of the fabricating spot was demonstrated. This result indicates the possibility of nanosize fabrication using the phase-change etching technique.
Numerical Analysis on Dual Holes Interactions

By extending Bückner’s superposition principle and alternating iteration method, this presentation studies the dual holes interactions. A newly developed numerical scheme is embedded in the conventional Gauss-Legendre quadrature routine for evaluating the boundary integral holding stress singularities. This developed scheme can avoid numerical singularity and facilitate the achieved stress field to be exact as that of analytical solution; however the chosen Gaussian integration points must enter a large quantity. This presentation uses an infinite plate with a centered hole strained by remote axial loading as a testing example, and the numerical results are capable of reaching the analytical solution in the evaluation. The accurate stress estimation in the stress field of the dual holes interacting can therefore locate the dual holes in a very close proximity and no divergence will occur during evaluating the interacting stress concentration between holes.
Joint Cardiac T1 Mapping and Cardiac Cine Using Manifold Modeling

The main focus of this work is to introduce a single free-breathing and ungated imaging protocol to jointly estimate cardiac function and myocardial T1 maps. We reconstruct a time series of images corresponding to k-space data from a free-breathing and ungated inversion recovery gradient echo sequence using a manifold algorithm. We model each image in the time series as a non-linear function of three variables: cardiac and respiratory phases and inversion time. The non-linear function is realized using a convolutional neural networks (CNN) generator, while the CNN parameters, as well as the phase information, are estimated from the measured k-t space data. We use a dense conditional auto-encoder to estimate the cardiac and respiratory phases from the central multi-channel k-space samples acquired at each frame. The latent vectors of the auto-encoder are constrained to be bandlimited functions with appropriate frequency bands, which enables the disentanglement of the latent vectors into cardiac and respiratory phases, even when the data are acquired with intermittent inversion pulses. Once the phases are estimated, we pose the image recovery as the learning of the parameters of the CNN generator from the measured k-t space data. The learned CNN generator is used to generate synthetic data on demand by feeding it with appropriate latent vectors. The proposed approach capitalizes on the synergies between cine MRI and T1 mapping to reduce the scan time and improve patient comfort. The framework also enables the generation of synthetic breath-held cine movies with different inversion contrasts, which improves the visualization of the myocardium. In addition, the approach also enables the estimation of the T1 maps with specific phases, which is challenging with breath-held approaches.
Identification of a pluripotency-inducing small compound, PLU, that induces callus formation via Heat Shock Protein 90-mediated activation of auxin signaling

Plants retain the ability to generate a pluripotent tissue called callus by dedifferentiating somatic cells. A pluripotent callus can also be artificially induced by culturing explants with hormone mixtures of auxin and cytokinin, and an entire body can then be regenerated from the callus. Here we identified a pluripotency-inducing small compound, PLU, that induces the formation of callus with tissue regeneration potency without the external application of either auxin or cytokinin. The PLU-induced callus expressed several marker genes related to pluripotency acquisition via lateral root initiation processes. PLU-induced callus formation required activation of the auxin signaling pathway though the amount of active auxin was reduced by PLU treatment. RNA-seq analysis and subsequent experiments revealed that Heat Shock Protein 90 (HSP90) mediates a significant part of the PLU-initiated early events. We also showed that HSP90-dependent induction of TRANSPORT INHIBITOR RESPONSE 1, an auxin receptor gene, is required for the callus formation by PLU. Collectively, this study provides a new tool for manipulating and investigating the induction of plant pluripotency from a different angle from the conventional method with the external application of hormone mixtures.
Exponential sums for O(2n+1,q) and their applications

For a nontrivial additive character \lambda and a multiplicative character \chi of the finite field with q elements (q a power of an odd prime), and for each positive integer r, the exponential sums \sum \lambda ((\tr w)^r) over w\in {SO}(2n+1,q) and \sum \chi (\det w)\lambda ((\tr w)^r) over {O}(2n+1,q) are considered. We show that both of them can be expressed as polynomials in q involving certain exponential sums. Also, from these expressions we derive the formulas for the number of elements w in {SO}(2n+1,q) and {O}(2n+1,q) with (\tr w)^r=\beta , for each \beta in the finite field with q elements.