Miracle-dz/UniFAR-FTUs huggingface dataset:
Induced in-plane magnetic anisotropy in YIG films

We have studied the symmetry properties of the in-plane induced magnetic anisotropy in {100} and {110} disks of single crystal YIG epitaxially grown on gadolinium gallium garnet (GGG) substrates. The ferromagnetic resonance (FMR) technique was used to determine the values of the cubic and induced magnetic anisotropies. The induced anisotropy is interpreted in terms of a magnetostrictive magnetic potential energy. We find that the effective field induced in the plane of the film is isotropic for {100} disks but for {110} disks the induced anisotropy is uniaxial within the plane.
Is adolescent internet use a risk factor for the development of depression symptoms or vice-versa?

Abstract Background The extent to which digital media use by adolescents contributes to poor mental health, or vice-versa, remains unclear. The purpose of the present study is to clarify the strength and direction of associations between adolescent internet use and the development of depression symptoms using a longitudinal modeling approach. We also examine whether associations differ for boys and girls. Methods Data are drawn from (N = 1547) participants followed for the Quebec longitudinal Study of Child Development (QLSCD 1998–2020). Youth self-reported internet use in terms of the average hours of use per week at the ages of 13, 15, and 17. Youth also self-reported depression symptoms at the same ages. Results After testing sex-invariance, random intercepts cross-lagged panel models stratified by sex, revealed that internet use by girls was associated with significant within-person (time-varying) change in depression symptoms. Girl's internet use at age 13 was associated with increased depression symptoms at age 15 (ß = 0.12) and internet use at age 15 increased depression at age 17 (ß = 0.10). For boys, internet use was not associated with significant time varying change in depression symptoms. Conclusions The present findings support the hypothesis that internet use by adolescents can represent a significant risk factor for the development of depressive symptoms, particularly in girls.
Frequency and Cost of Claims by Injury Type From the Korea Workers’ Compensation Insurance Between 2016 and 2019

Our findings provide useful information on the distribution of workers’ compensation by injury type and types of injuries with high costs. Regarding frequency and costs, hand/wrist/finger injuries were highest in cost, by single-injury type. Therefore, these injuries should be recognized as intervention targets. Objective This study aimed to examine the frequency of worker injuries by affected body part(s) and the associated costs. Methods: We performed a secondary analysis of national workers' compensation claims data from the Korean workers' compensation insurance. The main outcome measures were frequency and cost of claims by injury type. Results: Multiple injuries were ranked as the highest injury type in the number of annual claims and percentage of the total cost/total medical cost. Hand/wrist/finger was the most common single-injury type. The frequency of injury type and the cost amount payable as a percentage of the total cost were the highest for multiple injuries, hand/wrist/finger injuries, and knee/lower leg injuries. Conclusions: Regarding frequency and costs, hand/wrist/finger injuries were highest in cost, by single-injury type. Therefore, these injuries should be recognized as intervention targets.
Computationally efficient algorithms for constraint handling with guaranteed stability and near optimality

Predictive control strategies allow for the systematic handling of constraint, performance and stability. However, the associated algorithms can be computational burdensome and/or difficult to unravel. The aim of this paper is to discuss and compare algorithms based on invariant sets which meet the additional requirement for computational simplicity. There may of course be a concomitant loss of optimality, but as illustrated, this can be minimal and often is a small price to pay when one considers the significant improvements in efficiency.
Serum HMGB1 levels and its clinical significance in elderly patients with intertrochanteric fractures after intramedullary fixation surgery

Background: Intramedullary fixation is a valuable alternative for the treatment of intertrochanteric fractures. However, further development of new biomarkers to predict the prognosis of the patient is still needed for timely and effective treatment and intervention. The present study aimed to explore the serum high-mobility group box 1 (HMGB1) levels in the prognosis of intertrochanteric fracture patients and its correlation with clinical results. Methods: The present prospective cohort study recruited 115 intertrochanteric fracture patients who were admitted from January 2015 to December 2019. All patients were evaluated preoperatively and treated (proximal femoral nail antirotation or intramedullary proximal femoral nail) by the same team. The serum HMGB1, interleukin-6, interleukin-1β, tumor necrosis factor α, and C-reactive protein levels were measured by enzyme-linked immunosorbent assay. Demographic and clinical data of all patients were collected. Harris score was used to assess the prognosis of intertrochanteric fracture patients after 6 months of treatment. Statistical analysis was conducted using SPSS software with P < . 05 as statistically different. Results: The time of the operation and the amount of bleeding in intramedullary proximal femoral nail were remarkably elevated compared with the proximal femoral nail antirotation group (P < .05). The age, proportion of complications and visual analogue score VAS after 72 hours of surgery in the Harris score < 80 group were remarkably increased compared with Harris score ≥ 80 group (P < .05). In addition, we found that the serum HMGB1 levels in Harris score < 80 group were markedly elevated than the patients in Harris score ≥ 80 group at all time points (P < .05). The results showed that the serum HMGB1 levels at postoperative 48 hours had the highest predictive value for predicting poor prognosis in intertrochanteric fracture patients. It was found that HMGB1, age and VAS after 72 hours of surgery were the risk factors for poor prognosis of intertrochanteric fracture patients. Conclusion: This study showed that the serum HMGB1 levels was significantly decreased in intertrochanteric fracture patients with bad prognoses. This study may provide a new approach to screening intertrochanteric fracture patients with worse prognoses in advance.
Construction and evaluation of an antioxidant synergistic system containing vitamin C and vitamin E

Abstract Aims The aim of this study is to develop a liposome that could exert unparalleled antioxidant effects. In the present study, a vitamin C (VC)/vitamin E (VE)-co-loaded multivesicular liposome (VCVE-MVL) was constructed. Methods Vitamins were encapsulated in soybean phosphatidylcholine (SPC) and cholesterol (CHO) by multi-emulsification method. The concentration of VC was determined by Fast Blue method. The concentration of VE was determined by high performance liquid chromatography (HPLC). Vitamin antioxidant capacity in vitro and in vivo was determined using β-carotene bleaching. Results VCVE-MVL with particle diameter of 848.55 ± 0.29 nm and SPAN of 0.16 ± 0.11 were obtained. The encapsulation efficiency of VC reached 48.51% (w/w)±0.15. Compared with VC/VE solution, VCVE-MVL had a higher permeation efficiency. In addition, the in vitro and ex-vivo antioxidant tests verified the adequate antioxidant activity of VCVE-MVL. Conclusions In conclusion, the antioxidant synergistic system we constructed and demonstrated its potential applications in the cosmetics industry.
UHRF1-induced connexin26 methylation is involved in hearing damage triggered by intermittent hypoxia in neonatal rats

Abstract Ubiquitin-like with plant homeodomain and ring finger domains 1 (UHRF1) promotes the maintenance of established patterns of DNA methylation in mammalian cells. Extensive methylation of connexin26 (COX26) during hearing impairment has been demonstrated. The present study aims to determine whether UHRF1 can induce the methylation of COX26 in cochlea damaged by intermittent hypoxia (IH). After the establishment of the cochlear injury model through IH treatment or isolation of the cochlea containing Corti’s organ, pathological changes were observed via HE staining. Expressions of COX26 and UHRF1 were detected by quantitative reverse-transcription polymerase chain reaction and Western blot. The effect of COX26 methylation levels was analyzed by methylation-specific PCR (MSP). Phalloidin/immunofluorescence staining was used to observe structural changes. The binding relationship between UHRF1 and COX26 was verified by chromatin immunoprecipitation. IH caused cochlear damage, accompanied by increased methylation of COX26 and expression of UHRF1 in the cochlea of neonatal rats. CoCl2 treatment caused the loss of cochlear hair cells, downregulation and hypermethylation of COX26, abnormal upregulation of UHRF1, and disordered expressions of apoptosis-related proteins. UHRF1 in cochlear hair cells binds to COX26, and its knockdown upregulated COX26 level. Overexpressed COX26 partially alleviated the CoCl2-caused cell damage. UHRF1 induces COX26 methylation and aggravates the cochlear damage caused by IH.
Assessment of health equity consideration in Cochrane systematic reviews and primary studies on urolithiasis

Health injustice is defined as “unnecessary, preventable, unjustified and unfair health differences. ” One of the most important scientific sources on the prevention and management of urolithiasis are Cochrane reviews in this field. Given that the first step in eliminating health injustice is to identify the causes, the aim of the present study was to evaluate equity considerations in Cochrane reviews and the included primary studies on urinary stones.
A liquid crystal microwave wavelength selector

Many thermotropic liquid crystals have a high optical built by stacking 55 strips of aluminium with mylar spacers at each end. The crucial thickness of the mylarbirefringence. While this has been used extensively in low voltage driven liquid crystal displays it has yet to spaced gaps is only 75.0mm, which may be readily filled with a relatively small amount of liquid crystal. To be significantly exploited with microwaves, even though the birefringence extends into this frequency range. facilitate alignment of the liquid crystal, the aluminium slats are individually coated with a polyimide film, which A few microwave modulation devices involving waveguide or microstrip-line structures, which use the large is rubbed along the short axis direction of the slats to provide homogeneous alignment of the liquid crystal dielectric anisotropy of LC materials, have been reported. However, possibly through a perceived lack of suitable molecules. These coated aluminium slats are then stacked as the above array and capillary filled with E7 geometries for use of thin films of liquid crystal in the microwave wavelength range, few practicable devices nematic. Alternate slats are connected to an ac voltage source of 1 kHz, allowing the application of the same have been developed. Recently, however, a range of experiments and theoretical voltage across every gap. Figure 2 shows the frequencyand voltage-dependent models have been presented which show strongly enhanced transmission of electromagnetic radiation through thin, resonant transmission peaks for the sample with voltages varying from 0.0 to 7.0 V (running up the curves). This periodic metallic samples containing very narrow slits. Surface waves in the slits may set up coupled standing type of sample, for which there is no diffraction, can be described as a pseudo, or ‘metal-filled’ Fabry–Perot, the waves resulting in resonant field enhancements within the slits and strong transmission. We have now two highly reflecting surfaces being the front and back surfaces of the aluminium slats. developed this idea one stage further by filling the slits with liquid crystal, which leads to a voltage-controlled wavelength selector at microwave frequencies. The geometry utilised is shown in figure 1, where a very deep zero-order transmission metallic grating is
The Enormous Outburst of the 7.9 km s -1 Water-Maser Feature in Orion KL

We report on a spectacular flare in the water-vapor maser emission from the KL nebula, which we found in 1997 December. The flare, at a velocity of 7.9 km s" 1 , continued to increase in intensity exponentially and had a flux density greater than 3.5xlO 6 Jy. The central velocity of the flare component was 7.9 km s" 1 and the line width was less than 40 kHz. We did not detect a "rapid" time variation in the intensity. The flare component is currently increasing steadily. A preliminary VLBI observation was made using a Japanese domestic VLBI network, called J-Net, in order to determine the location of the flare. Its position is Q = 05 h 32 m 46 s . 6, 5 = -5°24'27. "2 (1950.0) ± 1". In this region, strong outbursts were reported during the period from 1979 August to 1985 November (Matveenko et al. 1988, AAA 49.131.147). Both the central velocity and the position of the present flare seems to be the same as that of previous ones. This suggests a common origin of these phenomena.
A Novel Memory Type in C. elegans Exhibits Post-Training Consolidation

Memories are often categorized into types, reflecting their behavioural, anatomical and molecular diversity: these classifications both aid understanding of the differences among varieties of memory and help delineate the unifying cross-species principles underlying them. In the nematode worm Caenorhabditis elegans, we find that an associative memory of the pairing of the normally attractive odorant benzaldehyde and starvation depends on de novo transcription and translation, is independent of CREB, and is produced by massed training: a pattern which does not correspond to any of the well-characterized molecular categories of invertebrate memory. Further, as has been shown for many memories in vertebrates, but not previously in nematodes, we find that formation of this memory continues after removal of the stimuli initially causing it, and that it is labile to disruption through protein synthesis inhibition following training, but that inhibition of proteasomal activity does not extend the duration of the memory. Previous findings have implicated insulin pathway signalling as a key component of this benzaldehyde/starvation memory, however we find that the transcriptional activity required for the memory is likely to be independent of the transcription factors that function at the terminus of this pathway. These findings better characterize this model associative memory in relation to other invertebrate memory types and identify ways in which it both shares their traits and differs from them.
A novel adjuvant formulation induces robust Th1/Th17 memory and mucosal recall responses in Non-Human Primates

After clean drinking water, vaccination is the most impactful global health intervention. However, development of new vaccines against difficult-to-target diseases is hampered by the lack of diverse adjuvants for human use. Of particular interest, none of the currently available adjuvants induce Th17 cells. Here, we develop and test an improved liposomal adjuvant, termed CAF®10b, that incorporates a TLR-9 agonist. In a head-to-head study in non-human primates (NHPs), immunization with antigen adjuvanted with CAF®10b induced significantly increased antibody and cellular immune responses compared to previous CAF® adjuvants, already in clinical trials. This was not seen in the mouse model, demonstrating that adjuvant effects can be highly species specific. Importantly, intramuscular immunization of NHPs with CAF®10b induced robust Th17 responses that were observed in circulation half a year after vaccination. Furthermore, subsequent instillation of unadjuvanted antigen into the skin and lungs of these memory animals led to significant recall responses including transient local lung inflammation observed by Positron Emission Tomography-Computed Tomography (PET-CT), elevated antibody titers, and expanded systemic and local Th1 and Th17 responses, including >20% antigen-specific T cells in the bronchoalveolar lavage. Overall, CAF®10b demonstrated an adjuvant able to drive true memory antibody, Th1 and Th17 vaccine-responses across rodent and primate species, supporting its translational potential.
Homogeneous estimates for oscillatory integrals.

Let u(x,t) be the solution to the free time-dependent Schrodinger equa- tion at the point (x,t) in space-time Rn+1 with initial data f. We characterize the size of u in terms Lp(Lq)-estimates with power weights. Our bounds are given by norms of f in homogeneous Sobolev spaces ˙ H s (R n ). Our methods include use of spherical harmonics, uniformity properties of Bessel functions and interpolation of vector valued weighted Lebesgue spaces.
MousePZT: A Simple, Reliable, Low-Cost Device for Vital Sign Monitoring and Respiratory Gating in Mice Under Anesthesia

Small animal studies in biomedical research often require anesthesia to reduce pain or stress experienced by research animals and to minimize motion artifact for imaging or other measurements. Anesthetized animals should be closely monitored to avoid complications and unintended effects of altered physiology during such procedures. Many currently available monitoring devices can be expensive, invasive, or interfere with experimental design. Here, we present a low-cost device, based on a simple piezoelectric sensor, with a custom circuit and computer software that allows for measurements of both respiratory rate and heart rate in a non-invasive, minimal contact manner. We find the accuracy of the MousePZT device in measuring respiratory and heart rate under anesthesia and with pharmacologically induced changes in heart rate match those of commercial or more invasive systems. We also demonstrate that changes in respiratory rate can precede changes in heart rate associated with alterations in anesthetic depth. Additional circuitry on the device outputs a respiration locked trigger signal for respiratory-gating of imaging or other data acquisition that has high sensitivity and specificity for detecting respiratory cycles. We provide detailed construction documents and all necessary microcontroller and computer software, enabling straightforward adoption of this device.
Understanding Cooperation in Inter-Organisational Systems

Cooperation in inter-organisational networks usually requires considerable up-front investments in information technology (IT) specific for this cooperation. It is therefore of great importance that participants in a network select the partners for which it is most likely that cooperation will succeed. This requires a thorough understanding of the network from every perspective. This paper presents an approach to facilitate such understanding by using graphical snapshots of relevant properties of each participant, based on concrete, quantifiable data. The graphical snapshots provide a bird's eye view of the network that enables matching partners to form groups based on similarity. The approach has been applied in a case study that analysed e-customs, a large distributed system that connects the customs organisations of a number of member states of the European Union. The graphical snapshots obtained by applying our approach showed similarities and disparities between countries that indicate opportunities and challenges in IT integration. Results suggest that if in need of successful cooperation in groups within an inter-organisational network, our approach will help the architect to ask the right questions. We have validated our approach by showing the results to experts in the e-customs project, who confirmed our findings.
Quantifying the contribution of subject and group factors in brain activation

Research in neuroscience often assumes universal neural mechanisms, but increasing evidence points towards sizeable individual differences in brain activations. What remains unclear is the extent of the idiosyncrasy and whether different types of analyses are associated with different levels of idiosyncrasy. Here we develop a new method for addressing these questions. The method consists of computing the within-subject reliability and subject-to-group similarity of brain activations and submitting these values to a computational model that quantifies the relative strength of group- and subject-level factors. We apply this method to a perceptual decision-making task (N=50) and find that activations related to task, reaction time (RT), and confidence are influenced equally strongly by group- and subject-level factors. Both group- and subject-level factors are dwarfed by a noise factor, though higher levels of smoothing increases their contributions relative to noise. Overall, our method allows for the quantification of group- and subject-level factors of brain activations and thus provides a more detailed understanding of the idiosyncrasy levels in brain activations.
A Unified Filtering Method for Estimating Asymmetric Orientation Distribution Functions: Where and How Asymmetry Occurs in the Brain

Numerous filtering methods have been proposed for estimating asymmetric orientation distribution functions (ODFs) for diffusion magnetic resonance imaging (dMRI). It can be hard to make sense of all these different methods, which share similar features and result in similar outputs. The objectives of this work are two-fold: to disentangle the various filtering methods proposed in the past for estimating asymmetric ODFs, and to study the occurrence of asymmetric patterns in dMRI brain acquisitions. Hence, we describe a new filtering equation for estimating asymmetric ODFs resulting from the unification of these previously proposed filtering methods. Our method is distributed as an open-source GPU-accelerated python software to facilitate its integration into any existing dMRI processing pipeline. Following its validation on toy datasets, we apply our method to multi-shell multi-tissue fiber ODF reconstructions for 21 subjects from the Human Connectome Project in test-retest acquisitions. Our results show that our method estimates branching, fanning, bending, ending and other complex asymmetric fiber configurations in less than 2 minutes. Also, our novel number of fiber directions (NuFiD) index reveals that the filtering reduces the number of peak directions in the resulting asymmetric representation. Finally, our MNI-aligned template of asymmetries, describing the degree of asymmetry of each voxel, suggests that at least 60% of brain voxels in a dMRI acquisition contain asymmetric fiber configurations.
Bathing induced

This chapter, although concentrating on non-epileptic events induced by bath will also consider epileptic disorders provoked by bathing to avoid confusion and misunderstanding. Probably the best-known paroxysmal disorder triggered by bathing is hot water epilepsy-a rare form of reflex epilepsy. It was mainly reported in countries where traditionally bathing is performed with very hot water and/or pouring water over the head [1]. Hot water epilepsy is more common in children and most frequently happens in boys with complex partial seizures constituting the main clinical presentation. In older children and adults with hot water-induced seizures, brain lesions have been revealed [2]. Hot water also precipitates epileptic seizures in patients with Dravet syndrome, and the occurrence of hot-water induced seizures in children before 1 year of age with other risk factors (i.e. complex febrile seizures) may predict the development of Dravet syndrome [3]. Bathing epilepsy-synonymously called water immersion epilepsy-has been described in children worldwide with a median age of onset 7 months, presenting with autonomic seizures, precipitated by bathing in normal temperature (36–38◦C) water [4]. There are several non-epileptic disorders triggered by bathing. Bathing is a known precipitator of paroxysms in children with alternating hemiplegia of child-