Miracle-dz/UniFAR-FTUs huggingface dataset:
The Lithosphere-Atmosphere-Ionosphere Coupling of Multiple Geophysical Parameters Approximately 3 Hours Prior to the 2022 M6.8 Luding Earthquake

Investigating various geophysical parameters from the Earth’s crust to the upper atmosphere is considered a promising approach for predicting earthquakes. Scientists have observed that changes in these parameters can occur days to months before earthquakes. Understanding and studying the impending abnormal phenomena that precede earthquakes is both urgent and challenging. On 5 September 2022, a magnitude 6.8 earthquake occurred in Sichuan, China, at 4:52:18 (Universal Time). The earthquake happened approximately 175 km away from an instrumental array established in 2021 for monitoring vibrations and perturbations in the lithosphere, atmosphere, and ionosphere (MVP-LAI). This array consisted of over 15 instruments that regularly monitor changes in various geophysical parameters from the subsurface up to an altitude of approximately 350 km in the ionosphere. Its purpose was to gain insights into the mechanisms behind the coupling of these different geospheres during natural hazards. The seven geophysical parameters from the MVP-LAI system simultaneously exhibited abnormal behaviors approximately 3 h before the Luding earthquake. These parameters include ground tilts, air pressure, radon concentration, atmospheric vertical electric field, geomagnetic field, wind field, and total electron content. The abnormal increase in radon concentration suggests that the chemical channel could be a promising mechanism for the coupling of geospheres. Furthermore, air pressure, the geomagnetic field, and total electron content exhibited abnormal characteristics with similar frequencies. Horizontal wind experienced temporary cessation or weakening, while vertical wind displayed frequent reversals. These anomalies may be attributed to atmospheric resonance before the earthquake. The results demonstrate that the coupling of geospheres, as indicated by the anomalous phenomena preceding an earthquake, could be influenced by multiple potential mechanisms. The multiple anomalies observed in this study provided approximately 3 h of warning for people to prepare for the seismic event and mitigate hazards.
A Comparison of the Oral Microbiota in Healthy Dogs and Dogs with Oral Tumors

Simple Summary The oral microbiota in dogs constitutes a complex community. In recent years, oral microbiota has caught the interest of many as it is thought to play a key role in systemic diseases, including cancer. In this study, our objective was to delineate the core oral microbiome of healthy dogs and to identify any differences between healthy dogs and those with oral tumors. Oral swabs, representing all oral niches, were taken from both groups and analyzed using DNA shotgun sequencing. The core oral microbiota of healthy dogs was determined, consisting of a total of 67 bacterial species. Significantly higher species richness and evenness were observed in healthy dogs, while there was no significant difference in community composition between the healthy dogs and the dogs with oral tumors. To our knowledge, our study is the first to use DNA metagenomic sequencing to determine a core oral microbiome. Our study provides a novel approach and insight into the composition of the oral microbiota of dogs. Abstract The aim of this study was to further describe the oral microbiota of healthy dogs by DNA shotgun sequencing and compare those to dogs with oral tumors. Oral swabs (representative of all niches of the oral cavity) were collected from healthy dogs (n = 24) and from dogs with different oral tumors (n = 7). DNA was extracted from the swabs and shotgun metagenomic sequencing was performed. Only minor differences in microbiota composition were observed between the two groups. At the phylum level, the Bacteroidota, Proteobacteria, Actinobacteriota, Desulfobacterota and Firmicutes were most abundant in both groups. Observed Operational Taxonomic Units—OTUs (species richness) was significantly higher in the healthy patients, but there was no significant difference in the Shannon diversity index between the groups. No significant difference was found in beta diversity between the groups. The core oral microbiota consisted of 67 bacterial species that were identified in all 24 healthy dogs. Our study provides further insight into the composition of the oral microbiota of healthy dogs and in dogs with oral tumors.
Bibliometric analysis of the global research status and trends of mechanotransduction in cancer

BACKGROUND The development of cancer is thought to involve the dynamic crosstalk between the tumor cells and the microenvironment they inhabit. Such crosstalk is thought to involve mechanotransduction, a process whereby the cells sense mechanical cues such as stiffness, and translate these into biochemical signals, which have an impact on the subsequent cellular activities. Bibliometric analysis is a statistical method that involves investigating different aspects (including authors’ names and affiliations, article keywords, journals and citations) of large volumes of literature. Despite an increase in mechanotransduction-related research in recent years, there are currently no bibliometric studies that describe the global status and trends of mechanotransduction-related research in the cancer field. AIM To investigate the global research status and trends of mechanotransduction in cancer from a bibliometric viewpoint. METHODS Literature on mechanotransduction in cancer published from January 1, 1900 to December 31, 2022 was retrieved from the Web of Science Core Collection. Excel and GraphPad software carried out the statistical analysis of the relevant author, journal, organization, and country information. The co-authorship, keyword co-occurrence, and keyword burst analysis were visualized with VOSviewer and CiteSpace. RESULTS Of 597 publications from 745 institutions in 45 countries were published in 268 journals with 35510 citation times. With 270 articles, the United States is a well-established global leader in this field, and the University of California system, the most productive (n = 36) and influential institution (n = 4705 citations), is the most highly active in collaborating with other organizations. Cancers was the most frequent publisher with the highest H-index. The most productive researcher was Valerie M. Weaver, with 10 publications. The combined analysis of concurrent and burst keywords revealed that the future research hotspots of mechanotransduction in cancer were related to the plasma membrane, autophagy, piezo1/2, heterogeneity, cancer diagnosis, and post-transcriptional modifications. CONCLUSION Mechanotransduction-related cancer research remains a hot topic. The United States is in the leading position of global research on mechano-oncology after almost 30 years of investigations. Research group cooperations exist but remain largely domestic, lacking cross-national communications. The next big topic in this field is to explore how the plasma membrane and its localized mechanosensor can transduce mechanical force through post-transcriptional modifications and thereby participate in cellular activity regulations and cancer development.
Neural-Network for Position Estimation of a Cable-Suspended Payload Using Inertial Quadrotor Sensing

: This paper considers a standard quadrotor drone with a cable-suspended payload and minimal sensor configuration. A neural network estimator is proposed to perform accurate real-time payload position estimation. A novel proprioceptive feedback measurement method is proposed, and a neural network has been trained with domain randomization. The network shows accurate zero-shot estimation, even with excitations never seen by the system before. This preliminary work has been tested in a simulated environment and aims to show that only onboard inertial sensing is enough to achieve the sought task. The presented work may open new applications for drone transportation in real environments subject to several perturbations.
The Social Change and the Shaping of Developmental Mode for the Minimum Living Security System in China

Since the Minimum Living Security System( MLSS) for urban- rural poor residents has been established,this system has been playing a very important role in securing the living of the poor in urban and rural area. Especially,during the first decade of 21st century the MLSS realizes the new development,and some new characteristics and developmental trends are emerging. Based on the statistics of MLSS on Beijing and China as a whole,this paper analyzes the development of MLSS in China,argues that the MLSS system has been expanded in China,there are some differences between urban MLSS and rural MLSS,the development of urban MLSS is inconsistent with the development trends of the disposable income of urban residents. The importance of MLSS is increasing,but the benefit level of MLSS is still low in contrast to some countries like Sweden,the total assistance rate of MLSS is going up,but in general the MLSS recipients accounts for about 5% of the total population,and the rate of social assistance differs from one provincial unite to another,etc.
CRISPR/Cas9-mediated Targeted Mutagenesis of Inulin Biosynthesis in Rubber Dandelion

Rubber dandelion (Taraxacum kok-saghyz) is a natural rubber-producing dandelion that has the potential to become an industrial crop. Inulin is a storage carbohydrate in rubber dandelion, and its synthesis competes with rubber production for assimilated carbon. We used the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) system to simultaneously target two sites in the gene that encodes 1-fructan:fructan-1-fructosyl transferase gene (1-FFT), a key enzyme in inulin biosynthesis. Agrobacterium rhizogenes and Agrobacterium tumefaciens-mediated plant transformation methods were used to generate transgenic plants with CRISPR/Cas9 elements. Transformation rates were 71% and 64% via A. rhizogenes and A. tumefaciens-mediated transformations, respectively. Mutagenesis was confirmed by the loss of restriction site method and Sanger sequencing. Of 13 transgenic plants obtained via A. rhizogenes, six showed editing of both target sites within the 1-FFT gene. Transgenic rubber dandelion plants were obtained within 10 weeks using A. rhizogenes-mediated transformation, which was much faster than the 6 months required for A. tumafaciens transformants. Of 11 transgenic plants obtained via A. tumefaciens, five showed mutations in both target sites. Reverse-transcription polymerase chain reaction confirmed Cas9 expression in all edited transformants. Both A. rhizogenes-mediated double-mutant transformants and A. tumefaciens-mediated double mutant transformants had lower levels of inulin than wild-type plants. Moreover, A. rhizogenes-mediated transformants had a higher rubber content than wild-type plants. Therefore, the present study validates the use of CRISPR/Cas9 gene editing as an efficient tool for the generation of useful mutations in rubber dandelion and could be implemented in future crop improvement approaches.
The electrical structure of the crust along Mianning-Yibin profile in the eastern edge of Tibetan plateau and its tectonic implications

A magnetotelluric sounding was carried out in the eastern edge of Tibetan plateau along Mianning-Yibin that starts from Kangdian Geo-axis (KDG) eastward crossing the Daliangshan block (DLSb) and ends in Sichuan basin block (SCb). A 2-D modeling with consideration of topography is used with the NLCG (Nonlinear conjugate gradient method) inversion.2-D electrical structure model of crust and upper mantle was constructed.The upward arched high conductive layer (HCL) exists in the crust of both KDG and DLSb, but not in SCb.The HCL has a low resistivity of 3～10 Ωm and its top is about 10～15 km deep (the shallowest less than 10km) with a thickness about 15～25 km.The crustal electrical structure combined with that of Shimian-Leshan profile indicates that the HCL is continuous and extends for more than 100 km in south-north direction.The high conductivity of HCL may be related to partial melt of rocks and some quantity of salt fluid prone to deformation and flow.The flow of HCL under the pushing force from Tibetan plateau is directed to E and/or SE in eastern Tibet plateau, and then turns to S or SSE in DLSb due to the obstruction of Sichuan basin.In EW direction it crosses the west boundary of DLSb, Anninghe fault (ANHf) and Zemuhe fault (ZMHf). The crust flow layer in the eastern DLSb underthrusts eastward beneath SCb.The relationship between the flow of HCL and the tectonic deformation of the crust and the seismicity is analysed in the article.
Effect of Adding a Phytogenic Plant Additive (PFA) in some Productive Traits of Broiler Chickens

This experiment was conducted in Poultry house of the Department of Animal Production / College of Agriculture / University of Basrah 19/11/2020 to 23/12/2020to find out the effect of adding the plant additive ((PFA) to feed and water at different time periods on some productive traits of broiler. Two hundred and fifty-two unsexed 1-day-old (ROSS 308) broiler chicks were randomly distributed in 7 groups each one consisting of 3 replicates (12 birds/replicate) as follows : The results showed that the addition of the phytoogenic to the diet or water led to a significant improvement (p≤0.05)in the productive characteristics, which included body weight, weight gain, feed intake, and feed conversion coefficient, compared to the control group The results showed that the addition of the phytoogenic to the diet or water led to a significant improvement (p≤0.05)in the productive characteristics, which included body weight, weight gain, feed intake, and feed conversion coefficient, compared to the control group.
Genome-Wide Analysis of Cation/Proton Antiporter Family in Soybean (Glycine max) and Functional Analysis of GmCHX20a on Salt Response

Monovalent cation proton antiporters (CPAs) play crucial roles in ion and pH homeostasis, which is essential for plant development and environmental adaptation, including salt tolerance. Here, 68 CPA genes were identified in soybean, phylogenetically dividing into 11 Na+/H+ exchangers (NHXs), 12 K+ efflux antiporters (KEAs), and 45 cation/H+ exchangers (CHXs). The GmCPA genes are unevenly distributed across the 20 chromosomes and might expand largely due to segmental duplication in soybean. The GmCPA family underwent purifying selection rather than neutral or positive selections. The cis-element analysis and the publicly available transcriptome data indicated that GmCPAs are involved in development and various environmental adaptations, especially for salt tolerance. Based on the RNA-seq data, twelve of the chosen GmCPA genes were confirmed for their differentially expression under salt or osmotic stresses using qRT-PCR. Among them, GmCHX20a was selected due to its high induction under salt stress for the exploration of its biological function on salt responses by ectopic expressing in Arabidopsis. The results suggest that the overexpression of GmCHX20a increases the sensitivity to salt stress by altering the redox system. Overall, this study provides comprehensive insights into the CPA family in soybean and has the potential to supply new candidate genes to develop salt-tolerant soybean varieties.
Adverse childhood experiences and mental ill-health - obesity comorbidity among British adolescents – A national cohort study

Background Mental ill-health and obesity are increasingly prevalent in childhood with both conditions likely to co-occur. Less is known about associations between adverse childhood experiences (ACEs) and mental ill-health and obesity (MH-OB) comorbidity in adolescence. The aim of this study was to examine associations between ACEs and MH-OB comorbidity in adolescents from a national cohort study. Methods Participants; 10,734 adolescents (males = 50.3%) from the Millennium Cohort Study with 6 ACEs (for e.g., parental MH, drug/alcohol misuse, physical punishment) collected prospectively between ages 3-11 years. MH-OB comorbidity (binary indicator) was based on objectively measured BMI (for overweight/obesity) and self-reported depression/anxiety at ages 14 and 17. Associations between: 1.total ACE scores (0, 1, 2 or ≥3) and additionally each individual ACE, and MH-OB, were analysed used logistic regression, separately at 14 and 17 years. Results At age 14, ACE scores were associated with higher odds for MH-OB comorbidity, with a gradient of increasing odds ratios (OR) with increasing ACEs. Individuals with 1 (OR:1.22[95%CI: 1.1-1.6]), 2 (OR:1.7[1.3-2.3]), or ≥3ACEs (OR:2[1.5-2.6]) had increased odds for MH-OB comorbidity compared to those with 0 ACEs. At age 17, associations between ACE scores and MH-OB were attenuated and observed in individuals with ≥3ACEs (OR:1.54, 1.1-2.3). Parental MH (OR:1.5, 1.2-1.9), intimate-partner violence (OR:1.2, 1.1-1.6), physical punishment (OR:1.3, 1.1-1.6), bullying (OR:2, 1.6-2.5) were associated with MH-OB comorbidity age 14. However, only parental MH (OR:1.5, 1.1-2.1) and bullying (OR:1.6, 1.2-2.1) were associated with MH-OB comorbidity at age 17. Conclusion ACEs are associated with increased risk of MH-OB comorbidity in between ages 14 and 17. These findings provide timely opportunity for interventions to reduce risk and are pertinent given that MH and obesity contribute significantly to global burden of disease and track across the lifecourse.
Attenuation of amyotrophic lateral sclerosis via stem cell and extracellular vesicle therapy: An updated review

Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly fatal neurological disease characterized by upper and lower motor neuron degeneration. Though typically idiopathic, familial forms of ALS are commonly composed of a superoxide dismutase 1 (SOD1) mutation. Basic science frequently utilizes SOD1 models in vitro and in vivo to replicate ALS conditions. Therapies are sparse; those that exist in the market extend life minimally, thus driving the demand for research to identify novel therapeutics. Transplantation of stem cells is a promising approach for many diseases and has shown efficacy in SOD1 models and clinical trials. The underlying mechanism for stem cell therapy presents an exciting venue for research investigations. Most notably, the paracrine actions of stem cell‐derived extracellular vesicles (EVs) have been suggested as a potent mitigating factor. This literature review focuses on the most recent preclinical research investigating cell‐free methods for treating ALS. Various avenues are being explored, differing on the EV contents (protein, microRNA, etc.) and on the cell target (astrocyte, endothelial cell, motor neuron‐like cells, etc.), and both molecular and behavioral outcomes are being examined. Unfortunately, EVs may also play a role in propagating ALS pathology. Nonetheless, the overarching goal remains clear: to identify efficient cell‐free techniques to attenuate the deadly consequences of ALS.
Green Synthesis of Gold, Silver, Copper, and Magnetite Particles Using Poly(tartaric acid) Simultaneously as Coating and Reductant

Poly(tartaric acid) is a relatively recently described polymer that can be easily synthesized and scaled up from a readily available renewable material (tartaric acid). This article demonstrates its use in a green synthesis of gold nanoparticles, silver nanoparticles, copper particles, and magnetite nanoparticles. In this case poly(tartaric acid) acts both as a reductant and as a coating agent. To our knowledge this is the first green synthesis of several different types of nanoparticles using only one reagent (polytartrate) as both reductant and coating. The resulting particles were analyzed by XRD, TEM/SEM, EDX, FTIR, DLS, zeta-potential, XPS, and UV/VIS spectroscopy. Preliminary studies of the thermal behavior of mixtures of different types of particles with poly(tartaric acid) were also conducted. The obtained particles show different sizes depending on the material, and the coating allows for better dispersibility as well as potential further functionalization, making them potentially useful also for other applications, besides the inclusion in polymer composites.
Heterogeneous 3-D Sequential CFETs With Ge (110) Nanosheet p-FETs on Si (100) Bulk n-FETs

In this study, we report on the fabrication and characterization of 3-D sequential complementary field-effect-transistors (CFETs) using the direct wafer bonding (DWB) technology and a low-temperature process for monolithic 3-D (M3D) integration. The device features a high-performance top Ge (110)/<inline-formula> <tex-math notation="LaTeX">$\langle 110\rangle $ </tex-math></inline-formula> channel on a bottom Si CMOS. To ensure high performance without causing damage to the bottom Si n-FETs, the maximum thermal budget during the fabrication of the top Ge p-FETs was limited to 400 °C. We systematically investigated the mobility enhancement of the thin Ge (110) nanosheet (NS) channel p-FETs as a function of channel orientation. Our results demonstrate that the low effective hole mass along the <inline-formula> <tex-math notation="LaTeX">$\langle 110\rangle $ </tex-math></inline-formula> direction on Ge (110) wafer provides record-high mobility of 400 cm2/<inline-formula> <tex-math notation="LaTeX">$\text{V}\cdot \text{s}$ </tex-math></inline-formula> (corresponding to 760 cm2/<inline-formula> <tex-math notation="LaTeX">$\text{V}\cdot \text{s}$ </tex-math></inline-formula> when normalized by footprint) at room temperature, which is the highest reported among the Ge p-FETs with similar channel thicknesses.
RADIO TRACKING THE MOVEMENTS AND ACTIVITIES OF HARBOR PORPOISES, PHOCOENA PHOCOENA (L.), IN THE BAY OF FUNDY, CANADA

•In all observed cases, the movement of radio-tagged porpoises coincided with the direction of tidal flow in the major channels and passages of the region. Analysis of 39.2 hours of ventilation sequences revealed that radio-tagged porpoises were relatively inactive from midnight until 0600 and more active during other periods. This report documents the results of a study on the movements and activities of radio-tagged harbor porpoises, Phocoenaphocoena, in the "Bay of Fundy, Canada. The primary objective of this research was to determine the home ranges of individual harbor porpoises during the summer months. The study also provided insights into the behavior and ac­
Acceptance of Digital Sales and Marketing Tools: A Customer Perspective on Intention to Use

: Digital sales and marketing tools are important for the success of modern business-to-business (B2B) companies. While many of these information systems or tools can also be used by the customer, surprisingly little is known about the customer’s perception of these tools and the acceptance process itself. This research targets this research gap by developing and testing a structural equation model (PLS-SEM) to investigate customer perceptions and intentions to use digital sales and marketing tools, namely sales configurators. An online questionnaire was developed, and the responses of 113 B2B professionals were analyzed. The results showed that customers’ intention to use digital sales and marketing tools was influenced by ease of use and perceived usefulness. Ease of navigation and information quality also played a significant role in the acceptance process of these tools.