Miracle-dz/UniFAR-FTUs huggingface dataset:
Analisis Perbandingan Metode Hierarchical dan Non-Hierarchical dalam Pembentukan Cluster Provinsi di Indonesia Berdasarkan Indikator Women Empowerment

The focus on improving the quality of women’s live to lessen discrimination and gender inequality is set in the fifth’s goals of SDGs. In Indonesia, the RPJMN 2020-2024 contains measure to improve the contribution of women to equitable development. The Central Bureau of Statistics has developed several indicators related to gender, including Gender Development Index (GDI) an Gender Empowerment Index (GEI), which contain women’s improvement on education and health as well as their participation in economic and political fields. The Ministry of Women’s Empowerment and Child Protection did a quadrant analysis to split Indonesia’s 34 provinces into four categories based solely on GDI and GEI using the national average as a constraint. This study compares the Hierarchical, K-Means, and Fuzzy C-Means method to form number of clusters in Indonesia based on the gender development and empowerment in 2021 in order to complement the quadrant analysis. To choose the number of optimum cluster, Elbow method and Calinski-Harabasz Index were used and the best k value is five. From the validation with Silhoutte Index, K-Means was chosen as the best clustering model.Keywords: clustering; fuzzy; k-means; hierarchical; women empowerment
Multifunctional agriculture as an integral part of rural development: Spatial concentration and distribution in Czechia

ABSTRACT The main purpose of the article is to present a spatial and temporal assessment of selected broadening and deepening activities associated with multifunctional agriculture in post-socialist Czechia. Although a number of studies of multifunctionality have been published, geographical assessment of multifunctional activities has been quite limited. The authors used quantitative research methods based on different data sources (Farm Structure Survey data and individual databases) to capture the dynamic and spatial distribution of selected multifunctional activities, specifically organic farming, agricultural anaerobic digestion plants, agritourism, and eco-agritourism. The analysis focused on two geographical attributes that influence the farming sector: conditions of an area for agriculture, and the importance of rural space. The results show that the role of multifunctional agriculture was strengthened as an integrating element of rural development in the period 2003–2013. Spatially differentiated growth of a number of farms that were developing broadening and deepening activities was particularly localized in mountainous areas. The authors conclude that multifunctional agriculture plays an integrating role in rural development in such regions because conditions for agriculture are a more crucial geographical attribute in its localization than the importance of rural space.
Journal of Geophysical Research: Biogeosciences Modeling hydrologic controls on sulfur processes in sulfate-impacted wetland and stream sediments

Recent studies show sulfur redox processes in terrestrial settings are more important than previously considered, but much remains uncertain about how these processes respond to dynamic hydrologic conditions in natural ﬁeld settings. We used ﬁeld observations from a sulfate-impacted wetland and stream in the mining region of Minnesota (USA) to calibrate a reactive transport model and evaluate sulfur and coupled geochemical processes under contrasting hydrogeochemical scenarios. Simulations of diﬀerent hydrological conditions showed that ﬂux and chemistry diﬀerences between surface water and deeper groundwater strongly control hyporheic zone geochemical proﬁles. However, model results for the stream channel versus wetlands indicate sediment organic carbon content to be the more important driver of sulfate reduction rates. A complex nonlinear relationship between sulfate reduction rates and geochemical conditions is apparent from the model’s higher sensitivity to sulfate concentrations in settings with higher organic content. Across all scenarios, simulated e − balance results unexpectedly showed that sulfate reduction dominates iron reduction, which is contrary to the traditional thermodynamic ladder but corroborates recent experimental ﬁndings by Hansel et al. (2015) that “cryptic” sulfur cycling could drive sulfate reduction in preference over iron reduction. Following the thermodynamic ladder, our models shows that high surface water sulfate slows methanogenesis in shallow sediments, but ﬁeld observations suggest that sulfate reduction may not entirely suppress methane. Overall, our results show that sulfate reduction may serve as a major component making up and inﬂuencing terrestrial redox processes, with dynamic hyporheic ﬂuxes controlling sulfate concentrations and reaction rates, especially in high organic content settings. important than previously thought. These reactions often take place in wetland, stream, and lake sediments, which can contain a mix of both surface water and underlying groundwater. Our study investigated how water ﬂuxes through these sediments can aﬀect sulfur reactions when the surface water and groundwater chemistry diﬀer signiﬁcantly, such as through inﬂuxes of surface water sulfur from mining activities. Using ﬁeld measurements and a computer model that simulates chemical reactions and water ﬂow, we found that water ﬂux drives water chemistry in wetland and stream sediments. This aﬀects how rapidly sulfur reactions occur, especially in organic-rich wetland sediments. The model showed sulfur reactions to dominate over iron reactions, which contradicts classic chemical thermodynamics. Also, when water ﬂuxes carry high sulfur concentrations into wetland sediments, sulfur reactions out compete production of methane, a strong greenhouse gas. Our results indicate that sulfur reactions can play a prominent role in terrestrial biogeochemistry, and the degree to which it does is aﬀected by hydrological ﬂuxes.
Perspectiva de tiempo futuro en adolescentes escolarizados de dos ciudades de Colombia

La perspectiva de tiempo futuro (PTF) es un proceso multidimensional de tipo cognitivo motivacional que influye en las decisiones de los adolescentes sobre su futuro. Este estudio pretendió analizar la relación entre la PTF y las variables sociodemográficas edad, grado educativo, género y ciudad de residencia, en una muestra de 982 estudiantes entre los 12 y 18 años de edad cronológica, de nivel socioeconómico medio bajo, que cursan el ciclo de educación media, en cinco colegios de dos ciudades de Colombia. A través de un estudio empírico analítico de corte transversal, con un diseño correlacional, se midieron las dimensiones actitud y orientación temporal y la extensión temporal a través del cuestionario los jóvenes y el futuro. Los resultados muestran que los estudiantes de grado undécimo, de género femenino, residentes en la ciudad de Acacias presentaron las medias más altas en la dimensión de actitud y orientación temporal. Se evidenciaron correlaciones significativas entre las dimensiones actitud y orientación temporal y extensión temporal con las variables sociodemográficas estudiadas. Esto confirma que los adolescentes de ambos géneros presentan interés en la planeación del futuro, la que es mayor según el grado educativo y difiere dependiendo del contexto donde viven.
Gecko-Inspired Controllable Adhesive: Structure, Fabrication, and Application

The gecko can achieve flexible climbing on various vertical walls and even ceilings, which is closely related to its unique foot adhesion system. In the past two decades, the mechanism of the gecko adhesion system has been studied in-depth, and a verity of gecko-inspired adhesives have been proposed. In addition to its strong adhesion, its easy detachment is also the key to achieving efficient climbing locomotion for geckos. A similar controllable adhesion characteristic is also key to the research into artificial gecko-inspired adhesives. In this paper, the structures, fabrication methods, and applications of gecko-inspired controllable adhesives are summarized for future reference in adhesive development. Firstly, the controllable adhesion mechanism of geckos is introduced. Then, the control mechanism, adhesion performance, and preparation methods of gecko-inspired controllable adhesives are described. Subsequently, various successful applications of gecko-inspired controllable adhesives are presented. Finally, future challenges and opportunities to develop gecko-inspired controllable adhesive are presented.
Discriminatory Desires and Disintegrated Sexual Selves: An Investigation into Selective Sexual Preferences and the Limitation of Sexual Autonomy

This article examines the apparent tension, recently highlighted by Amia Srinivasan, between sexual autonomy and one’s responsibility to critically engage with their desires in the context of Selective Sexual Preferences (SSP). Many see SSP, criteria employed for excluding and including potential sexual partners, as a fundamental expression of one’s sexual autonomy. Simultaneously, these preferences mirror oppressive social structures and have detrimental effects on already marginalized groups. Noting this politicalness, authors like Srinivasan hold that we have an obligation to critically engage with our desires. Such engagement impedes, however, our sexual autonomy, which presupposes we are all free in developing and enacting our desires. Sexual autonomy and moral responsibility seem to be at odds. This article argues that this tension is a fabrication. More specifically, it posits that SSP are morally objectionable because they signify a limitation of one’s own sexual autonomy and that of others. To do so, this article moves beyond the dominant liberal approach to autonomy and examines sexual autonomy through the lens of Catriona Mackenzie’s Integrated Bodily Perspective. Together with empirical findings regarding effeminophobia in the gay community, this reconceptualization shows that SSP signify a twofold limitation of sexual autonomy. SSP may be a symptom of the limited sexual autonomy of the individual expressing them. As SSP reify oppressive social norms, they can contribute to the disintegration of others’ sexual perspectives, thus constituting a limitation of their sexual autonomy as well. Consequently, this article argues that sexual autonomy is not limited by our obligation of critical reflection but can rather be enhanced by it. It lastly considers the position of critical reflection and argues that while insufficient, critical reflection marks a necessary, possible, and fruitful starting point for approximating sexual justice.
Estructura genética de poblaciones humanas del Curso Superior del río Aconcagua mediante SNPs informativos de ancestría

La arqueologia y la historia del Valle de Aconcagua dan cuenta de una gran variabilidad cultural. Recientes prospecciones arqueologicas sugieren que desde el Periodo Alfarero Temprano se visualizan dos areas diferenciadas culturalmente: valle de Putaendo y valle de Los Andes. Estas areas muestran diferencias en relacion al tipo de ceramica, desarrollo de petroglifos y patrones mortuorios. Junto con ello, las caracteristicas geograficas del valle de Aconcagua, especificamente la presencia del rio Aconcagua se presenta como una posible barrera geografica que influiria en el flujo de personas. A pesar de las implicancias que puede traer el estudiar poblaciones mestizas, las poblaciones de Aconcagua presentan caracteristicas demograficas que permitirian acercarnos a dilucidar estas diferencias, por lo que en este estudio se evaluo la existencia de diferencias geneticas entre las poblaciones del Curso Superior del rio Aconcagua (valle de Aconcagua) dada las diferencias culturales y la presencia del rio Aconcagua en el area. Se genotipificaron 40 individuos del valle de Putaendo, 28 individuos del valle de Santa Maria y 45 individuos del valle de Los Andes para 148 SNPs informativos de ancestria. Los resultados de ancestria muestran que las tres poblaciones presentan en promedio proporciones de los componentes ancestrales europeo (~54%), africano (~6%), indigena del norte (~13%) e indigena del sur (~27%) muy similares. El analisis de componentes principales muestra que no existe subestructuracion genetica entre las poblaciones del valle de Aconcagua, formando un unico cluster. Los valores de FST entre las poblaciones son muy bajos, lo cual es congruente con una escasa diferenciacion genetica entre las poblaciones. El analisis Discriminante de Componentes Principales muestra una sutil diferencia entre el valle de Putaendo y el valle de Santa Maria y el valle de Los Andes. El analisis de asignacion es coherente con los demas resultados, mostrando que el ~39% de los individuos es asignado correctamente a la poblacion a la cual pertenece. Los resultados sugieren una baja senal de diferenciacion genetica entre las poblaciones en estudio, aunque esta puede haber sido influenciada por el proceso de mestizaje durante la colonizacion europea, la cantidad de marcadores usados y/o la potencia de estos para distinguir dicha diferenciacion o que el rio Aconcagua no funciono necesariamente como una barrera el flujo de personas entre los valles existentes, sino mas bien como una barrera cultural y, posteriormente politico-administrativa.
L’escitalopram : un inhibiteur sélectif et un modulateur allostérique du transporteur de la sérotonine Escitalopram: A selective inhibitor and allosteric modulator of the serotonin transporter

MOTS CLÉS Dépression ; Escitalopram ; R-citalopram ; Transporteur membranaire de la sérotonine ; Inhibiteur sélectif de la recapture de la sérotonine Résumé Le citalopram (Séropram®) est un antidépresseur de type inhibiteur sélectif de la recapture de la sérotonine (ISRS) composé, à part égale, d’énantiomère S (escitalopram) et d’énantiomère R (R-citalopram). Il a été démontré que l’escitalopram présente une efficacité supérieure et un délai d’action plus court que la forme racémique (le citalopram). À l’inverse, le R-citalopram, non seulement dépourvu de propriété inhibitrice de la recapture de la sérotonine, contrecarre les effets du escitalopram observés aussi bien in vitro qu’in vivo. Le mécanisme par lequel le R-citalopram exerce son action n’est pas encore pleinement connu, cependant, l’hypothèse d’une interaction allostérique entre les énantiomères et le transporteur membranaire de la sérotonine (SERT) a été proposée. En effet, des études in vitro ont révélé l’existence d’au moins deux sites de liaison distincts sur le SERT : (1) un site primaire à haute affinité ou site orthostérique, responsable de l’inhibition de la recapture de la sérotonine (5-HT) et (2) un site allostérique à basse affinité qui module la liaison des ligands au site primaire. En présence de escitalopram seul, sa liaison au site allostérique renforce sa propre fixation au site primaire et augmente l’efficacité de l’inhibition de la recapture de la 5-HT. En revanche, en présence des deux énantiomères, la liaison du R-citalopram au site allostérique diminue l’action du escitalopram sur le SERT. L’hypothèse d’un tel mécanisme d’action ouvre un large champ de recherche ayant pour objectif de développer des antidépresseurs allostériques susceptibles
Livestock-Poisoning Plants of California

Author(s): Forero, Larry; Nader, Glenn; Craigmill, Arthur; Ditomaso, Joseph M; Puschner, Birgit; Maas, John | Abstract: Horses, goats, sheep, and cattle can sicken or die if they eat from a poisonous plant. The best strategy is just to keep these plants out of reach. Here are photos, ID info, and poisoning symptoms for more than 30 hazardous ornamental and range plants.
Human Health Risks of Persistent Organic Pollutant Exposures in the Canadian Arctic

Biomonitoring equivalents (BEs) are conversions of an external reference dose to an internal dose, against which biomonitoring data can be directly compared. In this work, BEs were developed for chlordane and toxaphene using one-compartment pharmacokinetic models. Since the technical form of chlordane was used in deriving BEs for the individual isomers, a secondary objective of this study was to examine the toxicities of the components of technical chlordane in a HEPG2 cell culture experiment. Oral reference doses were identified from various national and international regulatory agencies and sources. Pharmacokinetic parameters for chlordane and toxaphene were obtained from experimental data in rodent models. A set of BEs have been derived for the main chlordane isomers, cis-chlordane, trans-chlordane, cis-nonachlor, and transnonachlor, and the chlordane metabolite, oxychlordane. BEs were also derived for the main toxaphene isomers found in biota, Parlars No. 26, 50, and 62. Based on the LC50 from the in vitro study, trans-nonachlor was the most toxic, and the trans-isomers were more toxic than the cis-isomers (LC50: trans-nonachlor 0.010 mM; technical chlordane 0.051 mM; trans-chlordane 0.052 mM; oxychlordane 0.063 mM; cis-chlordane 0.077 mM; cis-nonachlor 0.088 mM). The derived BE values can be used as screening guidelines to assess the risk of biomonitoring data in human populations. The results of a HEPG2 cell culture experiment suggest that trans-nonachlor is more toxic than technical chlordane and, therefore, the BE for this compound may need to be
Depression, and Drug Adherence in Type 2 Diabetes Mellitus in Primary Care in the Kingdom of Bahrain

Depression stands out as the predominant risk factor among Type 2 diabetes (T2DM) patients. Depression and its association with drug adherence in T2DM patients are lacking in Bahrain. The current study aimed to examine the association depression in relation to drug adherence in T2DM in primary care centers in the Kingdom of Bahrain. This was a cross-sectional study that enrolled 455 people with T2DM. Data on demographics, risk behavior, and diabetes details were noted. Measuring tools such as patient health questionnaire (PHQ-9) to measure depression severity, and General Medication Adherence Scale (GMAS) were used to assess medical adherence respectively. Categorical variables and continuous variables were presented in a frequency table and mean ± SD/ Median (Min, Max) respectively. The data was analyzed using SPSS 24.0 software. The statistical significance threshold was set at p=0.05. The study involved participants with an average age of 54.5 ± 11.5 (M±SD) years. The frequency of depression based on PHQ-9 and medical adherence as per GMAS among T2DM patients was 30.5% and 79.1% respectively. There was a significant association between the prevalence of depression and adherence (x2 =25.03; P=0.001). Age (r=-0.121; P= 0.010), education (r=-0.096; P=0.040), family income (r=-0.101; P=0.031), physical activity (r=-0.193; P=0.001), and self-rated diabetes control within the last visit (r=-0.200; P=0.001) were significantly negatively correlated with PHQ – 9 scale. Likewise, age (r=-0.231; p=0.001), education (r=-0.123; p=0.008), nationality (r=-0.185; p=0.001), physical activity (r=-0.108; p=0.021), and self-rated diabetes control within the last visit (r=-0.139; p=0.003) were significantly negatively correlated with the GMAS scale. Our findings suggest that medical adherence is linked to depression. Age, height, education, family income, physical activity, and self-rated diabetes control in the previous visit are all important factors that are correlated to depression and drug adherence.
Advances in Nanoparticle-Enhanced Thermoelectric Materials from Synthesis to Energy Harvesting: A Review

This comprehensive review analysis examines the domain of composite thermoelectric materials that integrate nanoparticles, providing a critical assessment of their methods for improving thermoelectric properties and the procedures used for their fabrication. This study examines several approaches to enhance power factor and lattice thermal conductivity, emphasizing the influence of secondary phases and structural alterations. This study investigates the impact of synthesis methods on the electrical characteristics of materials, with a particular focus on novel techniques such as electrodeposition onto carbon nanotubes. The acquired insights provide useful guidance for the creation of new thermoelectric materials. The review also compares and contrasts organic and inorganic thermoelectric materials, with a particular focus on the potential of inorganic materials in the context of waste heat recovery and power production within industries. This analysis highlights the role of inorganic materials in improving energy efficiency and promoting environmental sustainability.
Super-Enhancer Dysregulation in Rhabdoid Tumor Cells Is Regulated by the SWI/SNF ATPase BRG1

Simple Summary Rhabdoid tumors are a group of rare and aggressive pediatric cancers that are associated with dismal survival rates. These tumors are classified within the ~20% of all cancers showing mutations in the subunits of the SWI/SNF chromatin remodeling complex. Chromatin remodelers are large protein complexes that control gene expression at least in part through regulating DNA accessibility. In rhabdoid tumor cell lines, which harbor inactivating mutations in the SMARCB1 gene, the SWI/SNF subunit BRG1—a synthetic lethal target in these cells—retains functionality in chromatin remodeling and regulation of the rhabdoid genome. The aim of this study was to assess the contribution of BRG1 to rhabdoid gene regulation across multiple rhabdoid cell lines. These data provide valuable insights in understanding how gene regulation following SMARCB1 loss is achieved, which may be broadly applicable to other cancers marked by SWI/SNF subunit mutation. Abstract Mutations in the SWI/SNF chromatin remodeling complex occur in ~20% of cancers. In rhabdoid tumors defined by loss of the SWI/SNF subunit SMARCB1, dysregulation of enhancer-mediated gene expression is pivotal in driving oncogenesis. Enhancer dysregulation in this setting is tied to retention of the SWI/SNF ATPase BRG1—which becomes essential in the absence of SMARCB1—but precisely how BRG1 contributes to this process remains unknown. To characterize how BRG1 participates in chromatin remodeling and gene expression in SMARCB1-deficient cells, we performed a genome-wide characterization of the impact of BRG1 depletion in multiple rhabdoid tumor cell lines. We find that although BRG1-regulated open chromatin sites are distinct at the locus level, the biological characteristics of the loci are very similar, converging on a set of thematically related genes and pointing to the involvement of the AP-1 transcription factor. The open chromatin sites regulated by BRG1 colocalize with histone-marked enhancers and intriguingly include almost all super-enhancers, revealing that BRG1 plays a critical role in maintaining super-enhancer function in this setting. These studies can explain the essentiality of BRG1 to rhabdoid tumor cell identity and survival and implicate the involvement of AP-1 as a critical downstream effector of rhabdoid tumor cell transcriptional programs.