Miracle-dz/UniFAR-FTUs huggingface dataset:
Mahuang Fuzi Xixin decoction ameliorates allergic rhinitis and repairs the airway epithelial barrier by modulating the lung microbiota dysbiosis

Background Allergic rhinitis (AR) is a common disorder, that burdens general well-being. Although the lung is connected to the upper respiratory tract, which is rich in microorganisms, no studies have reported the relationship between lung microbiota and AR. Mahuang Fuzi Xixin decoction (MFXD) is a traditional Chinese medicine (TCM) formula that is widely used to treat AR in the clinic but its underlying mechanism remains unclear. Hypothesis We hypothesized that lung microbiota is associated with the pathogenesis of AR, and MFXD can improve AR by regulating microbiota dysbiosis. Methods The ovalbumin-induced mouse AR model was used to evaluate the therapeutic effect of MFXD on AR. Then 16S rDNA amplicon sequencing, untargeted metabolomics, and other molecular biology technology were used to clarify the effects of MFXD on lung microbes dysbiosis and AR progression. Further, the human nasal epithelial cell line (HNEpCs) was used to evaluate the protective effect of MFXD on epithelial barrier damage caused by specific pathogens. Results MFXD decreased plasma histamine and IgE levels, ameliorated pathological damage, and diminished the expression of tight junction proteins (ZO-1 and occludin) in lung and nasal tissues. MFXD altered AR-induced microbiota dysbiosis in the lungs and also plasma metabolites. Oral administration of MFXD altered microbiota dysbiosis in lung and AR-associated metabolic disorders. The dominant bacteria in the lungs of AR mice damaged the airway barrier, and MFXD reversed this change. Conclusion This study revealed the correlation between the lung microbiota and AR in the mice model. We confirmed that lung microbiota plays a vital role in AR and that MFXD reduced damage to the epithelial barrier of the lungs and nasal mucosa by regulating lung microbiota and plasma metabolism imbalances. Our research provides a reference for the effect of lung microbiota on AR and provides a new idea for the treatment of AR.
On the Feasibility of Position-Flooding in Urban UAV Networks

While the capabilities of Unmanned Aerial Vehicles (UAVs) lay the foundation for exciting new applications, many communication challenges remain unsolved. To make UAV operation safer and more reliable, the establishment of an Unmanned Aerial Traffic Management (UTM) is necessary. The most important functions of such a system are Airspace Monitoring (AM) and Communication Aided Detect and Avoid (CADA). To realize CADA, UAVs must timely communicate their position to other UAVs nearby to avoid collisions. For AM, positions must be forwarded to a ground station e.g. through an ad-hoc network. In this work, we evaluate whether these two functions can be realized for dense urban UAV networks in a decentralized way by using position-flooding. To measure this, we select three flooding protocols from the literature. Further, we propose Rate Decay Flooding (RDF) as a novel flooding protocol, that leverages the fact, that position updates become less urgent the further they have travelled. RDF reduces the traffic density by lowering the data rate with which traffic is forwarded on every hop. All four protocols are evaluated in an open-source simulator. The results show that RDF can support position-flooding in networks more than twice the size compared to the next best protocol. In doing so, it generates 52% less data traffic and thereby allows for the concurrent use of the ad-hoc network for other use-cases such as remote control. Using RDF improves the position uncertainty of neighbors at a distance of 2500m by 180m.
Perceived Relationship Between Horizontal Violence and Patient Safety Culture Among Nurses

Objective Despite the value of undertaking patient safety culture, its association with horizontal violence in nursing workplace is still understudied. This study aimed to investigate the association between the perceived patient safety culture and its relationship with horizontal violence among nurses working in Jordan. Methods A cross-sectional correlational design was used. Nurses working in major governmental hospitals in Jordan were conveniently recruited to complete an online self-administered questionnaire, which included the following tools: Hospital Survey on Patient Safety Culture and Negative Behaviours in Healthcare (NBHC) Survey. The survey was designed to measure attitudes and perceptions on patient safety culture at multiple levels of a healthcare organization with ten dimensions. The Negative Behaviours in Healthcare (NBHC) survey was developed as an adaptation of the Lateral Violence in Nursing Survey (LVNS) with 25 items and two open-ended questions. Results A total of 330 nurses responded to the questionnaire. Nurses moderately perceived patient safety culture (HSOPS mean = 3.5, SD = 1.1). Low incidence of horizontal violence was claimed (mean = 2.1, SD = 1.1). However, it was associated with moderate negative correlation with patient safety culture (r = −0.53, p < 0.001). Regression model revealed that patient safety culture explained an additional 53% of the variance of horizontal violence after controlling the effects of age and length of clinical experience (R-square change: 0.560, SE: 19.7, P: 0.001, CI: 1.21–1.57). Conclusion Despite its low incidence, patient safety culture was found influential to the horizontal violence based on the perspectives of nurses in Jordan. Patient safety culture can be incorporated with other factors that contribute to the development of horizontal violence in nursing workplace.
Optimization of the Zebrafish Larvae Pentylenetetrazol-Induced Seizure Model for the Study of Caffeine and Topiramate Interactions

Epilepsy is a common neurological disorder characterized by seizures that cause neurobiological and behavioral impairment. Caffeine (CAF), which is the most widely consumed stimulant in the world, is reported to influence epileptic seizures and antiepileptic drugs, especially topiramate (TPM). The aim of the study was to optimize the zebrafish larvae pentylenetetrazol-induced seizure model for the study of CAF and TPM interactions, which include the determination of dose space, and the delivery of an analytical method for monitoring CAF, TPM, and CAF metabolite paraxanthine (PAR) in Zebrafish larvae. Methods: The zebrafish larvae, 4 days post-fertilization, were incubated for 18 h with CAF, TPM, or CAF + TPM, with subsequent locomotor activity assessment. Seizures were evoked by adding PTZ solution to obtain a final concentration of 20 mM. Subsequently, the liquid chromatography–mass spectrometry (LC–MS/MS) analytical method was used to simultaneously assess the levels of both CAF and TPM in the larvae. CAF (50 mg/L) and TPM (75 μM) given separately decreased the average larvae locomotor activity compared to the PTZ group but, however, were not able to lower it to the control level. Co-administration of 25 mg/L CAF and 50 μM TPM suppressed the activity to the same level. Adding 25 μM TPM to 50 mg/L CAF decrease the measured CAF level in the larvae. Until proven otherwise, CAF consumption should be regarded as a potential determinant in the modulation of TPM’s efficacy in the management of epileptic seizures. The optimized model will contribute to the standardization of studying CAF and TPM interactions and building the understanding of the molecular bases of the interaction.
Modulation of Autophagy and Cell Death by Bacterial Outer-Membrane Vesicles

Bacteria, akin to eukaryotic cells, possess the ability to release extracellular vesicles, lipidic nanostructures that serve diverse functions in host–pathogen interactions during infections. In particular, Gram-negative bacteria produce specific vesicles with a single lipidic layer called OMVs (Outer Membrane Vesicles). These vesicles exhibit remarkable capabilities, such as disseminating throughout the entire organism, transporting toxins, and being internalized by eukaryotic cells. Notably, the cytosolic detection of lipopolysaccharides (LPSs) present at their surface initiates an immune response characterized by non-canonical inflammasome activation, resulting in pyroptotic cell death and the release of pro-inflammatory cytokines. However, the influence of these vesicles extends beyond their well-established roles, as they also profoundly impact host cell viability by directly interfering with essential cellular machinery. This comprehensive review highlights the disruptive effects of these vesicles, particularly on autophagy and associated cell death, and explores their implications for pathogen virulence during infections, as well as their potential in shaping novel therapeutic approaches.
Investigation of the Fracture and Fragmentation of Implosively Driven Thin-Walled Cylindrical Shell: From Thermodynamic Analysis to CDEM Simulation

The scattering of fragments is a notable characteristic of the explosive detonation of a shelled charge. This study examines the fracture and fragmentation of the shell and the process by which natural fragments form under the strains of implosion. The analysis takes into account both the explosive’s energy output and the casing’s dynamic response. For this purpose, utilizing a thermochemical code as an alternative to the conventionally employed cylinder test, the Jones–Wilkins–Lee equation of state (JWL EOS) was calibrated within a range of relative specific volume up to 13. The detonation of the shelled charge was subsequently analyzed using the continuum–discontinuum element method (CDEM). Following this, the formation mechanisms and scattering characteristics of natural fragments were scrutinized. The analysis found that the shell predominantly experiences shear failure with uniform evolution, displaying a “hysteresis effect” and two mutation stages in the evolution of tensile failure. Within the JWL EOS’s calibrated range, the representation of fragment displacement and velocity improved by 47.97% and 5.30%, respectively. This study provides valuable guidance for designing the power field of warheads and assessing their destructive power.
Expectation Propagation Detection for Polarization Modulation

Polarization modulation (PM) is a recently developed multiple-input multiple-output (MIMO) toward low-cost implementation by exploiting the polarization degree of freedom in an efficient way. In the context of a PM transmitter, an improved expectation propagation (EP) detector is proposed in this contribution, while the bit-error rate (BER) performance and computational complexity are both evaluated and quantified respectively. We demonstrate that the proposed detector outperforms its original EP-based counterpart and traditional linear minimum mean square error (LMMSE) detector as a promising receiver design for PM systems.
The research on fault diagnosis of rolling bearing based on current signal CNN-SVM

This article proposes a novel approach to address the issues of low accuracy in fault diagnosis and the difficulty in installing sensors on rolling bearings in mechanical and electrical equipment systems. To accomplish fault diagnosis of rolling bearings, a network structure algorithm based on convolutional neural network (CNN) and support vector machine (SVM) is presented, which incorporates the electric motor current signal. Firstly, the collected electric motor current signal is subjected to a wavelet filter with a soft-hard threshold to eliminate the noise. Secondly, the processed data is fed as input to a one-dimensional CNN to perform feature extraction and dimensionality reduction. Finally, the dimensionality-reduced features are processed by a SVM to diagnose rolling bearing faults. The research results indicate that the proposed method significantly improves the accuracy of rolling bearing fault diagnosis compared to other approaches, with an accuracy of up to 99.01%. This study introduces an innovative approach that can be applied to the field of rolling bearing fault diagnosis, offering valuable insights for research and application in this domain.
Tourism Economics, the Environment and Development: Analysis and Policy

Part 1 An overview: topics and issues in tourism economics -an overview of this book. Part 2 Tourism and the environment -market and political failures and public economics: tourism, the environment and profit public finance and appropriation of gains from international tourists - some theory with ASEAN and Australian illustations national gains from international tourism in the light of environmental factors - further considerations international competition for tourist development - politics and global environmental deterioration ecotourism, economics and the environment - observations from China investment in ecotourism -assessing its economics why care is needed in applying indicators of the sustainability of tourism, Clem Tisdell and Jie Wen total economic valuation of protected areas, Clem Tisdell and Jie Wen sustaining and maximizing economic gains from tourism based on natural sites - analysis with reference to the Galapagos, Clem Tisdell measuring the costs to tourism of pollution, especially marine pollution - analysis and concepts, C.A. Tisdell et al ecotourism - aspects of its sustainability and compatibility with conservation, social and other objectives. Part 3 Tourism in development and in less developed areas - mainly case studies: seasonality in tourism and the desirability of evening out tourism demand, C.A. Tisdell peripheral tourism - development and management, Andreas Hohl and Clem Tisdell tourism development in India and Bangladesh - general issues, illustrated by ecotourism in the Underbans tourism as an industry for the economic expansion of archipelagoes and small island states, C.A. Tisdell and D. McKee tourism and the economic development of the Maldives, R. Sathiendrakumar and C.A. Tisdell foreign tourism -benefit to China and contribution to development, C.A. Tisdell foreign tourism as an element in P.R. China's economic develpment strategy, C.A. Tisdell and J. Wen investment in China's tourism industry - its scale, nature and policy issues, C.A. Tisdell and J. Wen tourism development in China - its nature, the changing market and business opportunities spatial distribution of tourism in China - economic and other influences, Jie Wen and Clem Tisdell. Part 4 Tourism/recreational use of natural areas and wildlife - issues in environmental conservation: the value of, demand for and supply of National Parks - economic issues raised by recreational use recreational scuba-diving and carrying capacity in marine protected areas, Derrin Davis and Clem Tisdell economic management of recreational scuba diving and the environment, Derrin Davis and Clem Tisdell tourist levies and willingness to pay for a whale shark experience, Derrin David and Clem Tisdell tourism and the conservation of sea turtles - an Australian case study, Clem Tisdell and Clevo Wilson.
Robust adaptive quadrotor position tracking control for uncertain and fault conditions

The combination of nonlinear indirect and direct adaptive control with an active fault-tolerant framework is proposed in this paper for quadrotor position tracking control under uncertain and fault conditions. An inner loop direct model reference adaptive controller generates the required force while moving along the reference trajectory, while nonlinear indirect adaptive controller maintains the required attitude angles. Furthermore, for uncertain conditions, our proposed framework provides significantly stable characteristics. Otherwise, when a fault occurs at actuators or sensors, the quadrotor vehicle cannot guarantee global asymptotic stability. This study contributes to an active fault-tolerant control strategy for solving the complex position tracking problem using the adaptive two-stage Kalman filter (ATSKF). Based on the fault information, a fault compensation term is added to the control law to improve convergence and system robustness in the presence of uncertain and fault conditions. Finally, simulation results show satisfactory performance for quadrotor vehicle position tracking, even with actuator faults and uncertainties.
Using Community Cultural Wealth: An Asset-Based Approach to Persistence of On-Campus Black and Latinx Collegians

In this qualitative study, we took a novel approach of adopting an asset-oriented mindset based on Yosso's community cultural wealth framework. We conducted individual interviews at a large land-grant institution to understand the experiences of Black- and Latinx-identified on-campus collegians. Our goal was to explore the types of resistant capital employed by collegians of color to address both experienced and anticipated opposition. Resistant capital refers to the skills and strengths individuals use to overcome challenges. In this study, we presented our findings on the challenges and strategies utilized by the participants. By delving deeper into these experiences, we hope to contribute to a more comprehensive understanding of the experiences of underrepresented collegians.
Slotted Waveguide Circularly Polarized Leaky Wave Antenna With Improved Efficiency at W-Band

This article presents a high-efficiency circularly polarized slotted waveguide leaky wave antenna for the W band frequency range. The wall thickness of the slotted waveguide leaky wave antenna containing the radiating slots is tuned to optimize the overall antenna performance. A thin dielectric layer with an array of metallic patches has been used as a linear-to-circular polarization converter. The fabrication challenges of the W band antenna have been overcome by CNC milling machines which provide a high degree of precision and accuracy. The gain of the prototype antenna is above 20 dBi in the intended operating band from 92 GHz to 98 GHz. Furthermore, the antenna provides an average half-power beamwidth (HPBW) of 3.2° in the elevation plane and a cross-polarization level below -18 dB in the main beam direction. The combination of its robust design, reliable fabrication, simple configuration, and superior performance makes the proposed antenna a strong candidate for various W band applications.
Algae Incorporation and Nutritional Improvement: The Case of a Whole-Wheat Pasta

Algae contain high-quality proteins, dietary fiber, minerals, and phenolic compounds, making them promising alternative ingredients. Since pasta is consumed worldwide, it can be an effective vehicle for incorporating algae. This study compares the nutritional and antioxidant composition of whole-wheat pasta without and with enrichment of an algae mixture (containing Himanthalia elongata and Spirulina) and ascertains the influence of the cooking procedure on their features. Spirulina and H. elongata were also analyzed in parallel for comparison purposes. Macronutrients, chlorides and salt, total and free amino acid profiles, and antioxidant properties (total phenolic content and ferric reducing antioxidant power) were analyzed using AOAC, Mohr’s, high performance liquid chromatography with fluorescence detection, and spectrophotometric methods, respectively. The results show a significant increase in fat (70.4%), protein (29.7%), ash (26.5%), and total amino acid (except for serine, tryptophan, isoleucine, and threonine) contents in the raw algae-enriched pasta. The antioxidant activity was also higher (4.15 versus 3.68 g ferrous sulfate eq./g dw, respectively). After cooking, protein, dietary fiber, total amino acids (except threonine) and antioxidant activity were stable in the algae-enriched pasta. Thus, algae can be an excellent ingredient for food applications with health benefits.
How Brand Community Contribute To WOM And Loyalty : Evidence From Railfans Community

Today's brand community is not only a marketing medium for companies, but also a long-term business strategy to maintain the existence of a brand. Brand community strategies tend to be found in products owned by consumers directly such as ownership of motorized vehicles, automotive, mobile phones, and electronic devices. However, there are also service companies that implement brand community strategies, one of which is PT. Indonesian Railroad (Persero). This study aims to analyze the influence of the brand community on word of mouth and loyalty to the Railfans community of PT. Kereta Api Indonesia (Persero) in the Central Java Region. This research is a type of quantitative research using a survey method using a questionnaire given to Railfans members in the Central Java region. Sampling was determined using the purposive sampling method, with a total of 130 Railfans members. The data obtained were analyzed using the AMOS Structural Equation Model (AMOS SEM). The results showed that community identification did not have a positive effect on participation. The satisfaction of community members has a positive influence on participation. Community-brand member relationships have a positive influence on participation. Participation has a positive influence on word of mouth. Participation has a positive influence on loyalty.
Moored Observations to Define the Structure and Energetics of Non-Linear Internal Wave Generation Over the New Jersey Shelf

Abstract : LONG-TERM GOALS: To further our understanding of NLIW generation, to aid our NLIW prediction ability, and to quantify NLIW effects on acoustics, optics, energy dissipation, and momentum transfer in the coastal ocean. OBJECTIVES: What environmental factors define the structure and energetics of non-linear internal wave generation, and how can theses be used to predict intensity and quality of a wave packet. Specifically: * Under what conditions (stratification, barotropic forcing and topography) are NLIWs generated? What factors determine whether waves of elevation or waves of depression form? How are these influenced by the location of the shelf-break front? * What are the generation mechanisms? 1. barotropic via either a nonlinear version of Baines' (1982), or a controlled hydraulic flow which is released at low Froude numbers; or, 2. baroclinic, whereby a nearly-linear internal tide is generated and undergoes nonlinear transformations either locally or after having propagated many wavelengths. * What are the conversion efficiencies (i.e., the rates of energy transfer from linear to nonlinear waves, or from barotropic to baroclinic waves), and what fraction is dissipated locally? What fraction radiates away from the shelf break (forming the red beams in figure 2). * How do the near-bottom and near-surface signatures differ for these two types of waves. How important is the bottom stress? Can a surface expression for waves of elevation be detected?
A Study on IFN-γ and IL-10 Gene Expression Changes in Gallus gallus Embryo Infected with Pseudomonas aeruginosa and Its Possible Restoration by Bakreshwar Hot Spring Water

Bakreswar hot spring is a naturally occurring hot spring located at Birbhum district in West Bengal, India. The surface temperatures of the hot springs varies between 35°C to 66°C. The water of hot spring is alkaline with pH 9 and has curative properties. Pseudomonas aeruginosa is an important pathogen causing hospital acquired infections and in this study we used multi-drug resistance (MDR) isolate. The motive of the study is to compare the IL-10 and IFN-γ gene expression changes in Gallus gallus domesticus embryo infected with Pseudomonas aeruginosa by using the Bakreswar hot spring water.The curative properties of the hot spring water collected from Agnikund (65°C) was studied on 14thdays old chick eggs infected with Pseudomonas aeruginosa. After harvesting and allantoic fluid collection, RNA extraction was done and cDNA synthesis and RT-PCR were performed. After infection of the chick embryo with MDR Pseudomonas aeruginosa, both IL-10 and IFN-Ƴ gene expressions were increased, but in the curative sets those were challenged with Bakreswar hot spring water IL-10 and IFN- γ both gene expressions were decreased. From this study we may conclude that hot spring water of Bakreswar has antimicrobial activity against Pseudomonas aeruginosa due to which it decreses the cytokine gene expressions.