Miracle-dz/UniFAR-FTUs huggingface dataset:
This information is current as Mouse and Human Immunology Of Mice and Not Men : Differences between

Mice are the experimental tool of choice for the majority of immunologists and the study of their immune responses has yielded tremendous insight into the workings of the human immune system. However, as 65 million years of evolution might suggest, there are significant differences. Here we outline known discrepancies in both innate and adaptive immunity, including: balance of leukocyte subsets, defensins, Toll receptors, inducible NO synthase, the NK inhibitory receptor families Ly49 and KIR, FcR, Ig subsets, the B cell (BLNK, Btk, and (cid:1) 5) and T cell (ZAP70 and common (cid:2) -chain) signaling pathway components, Thy-1, (cid:2)(cid:3) T cells, cytokines and cytokine receptors, Th1/Th2 differentiation, costimulatory molecule expression and function, Ag-presenting function of endothelial cells, and chemokine and chemokine receptor expression. We also provide examples, such as multiple sclerosis and delayed-type hypersensitivity, where complex multicomponent processes differ. Such differences should be taken into account when using mice as preclinical models of human disease. The Journal of Immunology, 2004, 172: 2731–2738.
Molecular simulation study of the curling behavior of the finite free-standing kaolinite layer

Since kaolinite nanolayers potentially have many important applications, it is crucial to determine the factors that govern their curling behavior. The curling of a single-layer, free-standing kaolinite nanoparticle consisting of nearly 1 million atoms is studied with classical molecular dynamics simulation. Two up-to-date force fields are employed to describe the atomic interactions in the clay. The influence of force field details and of the use of different treatments of interactions (long range correction, potential cut-off radius) on the curling direction is systematically examined. That includes a practically infinite potential cut-off, which means that all atomic interactions are considered explicitly. For every inspected case, the structure is characterized by the overall shape of the particle, the axis of roll-up and particular bond lengths and angles. Both of the two possible curling directions are detected in the present simulations, which contradicts the crystallographic assumption that the constituent tetrahedral sheet can exclusively be on the concave side of curled kaolinite nanolayers.
CASE STUDY Congestion Avoidance in Wireless Networks by Analysis of People Mobility Behavior Study

: Wireless Local Area Networks (WLAN) are mostly used in various standard organizations and universities in the world. A WLAN links two or more devices using some wireless distribution method and usually provides a connection through an Access Point (AP) to the wider internet. This enables the users to move around within the organization or university campus and still be connected to the WLANs. This is a system that enables wireless interconnection of access points in an IEEE 802.11 network. It allows a wireless network to be expanded using multiple APs. The proposed Wireless Distribution System (WDS) preserves the MAC addresses of client packets across links between various APs. This WDS approach analyses people mobility behavior and provides the information about where the most number of users are using the same APs that leads to congestion in wireless networks. Further more, this WDS also gives best solution for Congestion Avoidance in wireless networks.
Neutrophil myeloperoxidase index in pediatric acute appendicitis Neutrofilni mijeloperoksidazni indeks u akutnom apendicitisu kod dece

Background/Aim. Diagnosis of acute appendicitis (AA) remains the most common dilemma of pediatric surgical team. Our aim was to determine whether the neutrophil myeloperoxidase index (MPXI), in combination with other laboratory and clinical parameters, can be useful in diagnosis and follow-up of AA in children. Methods. A prospective investigation of MPXI values in 117 consecutive patients, planned for the surgical intervention due to AA, was performed. The patients were stratified into three groups according to the intraoperative finding: the normal/early, uncomplicated and complicated AA. Laboratory analyses were done preoperativly, on the 1st and on the 3rd postoperative days. Results. The statistically significant difference of MPXI values between the uncomplicated and complicated appendicitis before surgery and the positive correlations between the MPXI and C-reactive protein, as well as inter-leukin-6, before surgery were found. Postoperatively, in the group of uncomplicated, as well as complicated AA, a significant decrease of MPXI was recorded. Conclusion. The MPXI may be used as an informative biomarker in the fol-low-up of AA in children. A wide reference range for the MPXI and individual differences in the values of MPXI in the healthy children, generate difficulties for its use for the initial diagnosis of acute appendicitis. Usefulness of MPXI determination decreases with a delayed diagnosis.
Rapid path planning algorithm for mobile robot in dynamic environment

Searching the lowest-cost path through a graph is central to many problems, including path planning for a mobile robot. By combining Dijkstra’s algorithm, A* algorithm, and rolling window principle, a new rapid path planning algorithm for a mobile robot in dynamic environment is proposed. First, Dijkstra’s algorithm is applied to find an initial path from the initial state to the goal. As a robot moves along the path, if a possible collision is predicted, a local optimal target state within the detection range of the sensors is selected using the rolling window principle. Then, an optimal path from the robot’s current location to this local target is searched through A* algorithm and a new path which leads the robot to move from current location to the goal is obtained. Compared to other algorithms, such as ant colony optimization algorithm, A* algorithm, and D* algorithm, the proposed algorithm can always find an optimal path during re-planning and at the meantime greatly reduce the re-planning time. The simulation results prove the feasibility and effectiveness of the proposed algorithm.
A Casual Network Based System for Predicting Multi-stage Attack with Malicious IP

: Multi-stage attacks are attacks executed in phases where each phase of the attack solely relies on the completion of the preceding phase. These attacks are so cleverly designed that they are able to elude detection from most network instruction detection systems and they are capable of infiltrating sophisticated defenses. In this paper, we proposed and designed a probabilistic inference system for predicting Multi-stage attack with malicious IP based on a supervised machine learning technique called Casual Network; otherwise known as Bayesian Belief Network (BBN) Model. The BBN model was designed on Unbbayes Simulator. The fusion of the proposed inference system and BBN model will assist in the prediction of perpetrated multi-stage attacks from computing devices and its means of identification on a computer network (IP address) before the completion of the said attack and hence help reduce the effects of this kind of attacks on networks by providing information which can be used as a measure to safeguard against this kind of stylish attack.
Enterocutaneous Fistula: Guidelines for an Evolving Problem

Importance: The care and outcome of enterocutaneous fistula (ECF) have improved greatly over several decades due to revolutionary advances in nutrition, along with dramatic improvements in the treatment of sepsis in the critically ill. However, as the collective experience with damage control surgery has matured, the frequent development of enteroatmospheric fistulas (EAF) in the open abdomen patient has emerged as an even more vexing problem. Despite our best efforts, ECFs and especially EAFs continue to be highly morbid conditions, and sepsis and malnutrition remain the leading causes of death. Aggressive nutritional, metabolic support and multidisciplinary approach is the most significant predictor of outcome with ECFs and EAFs. Observations: Discussion of the historical advances in therapy and their impact on ECFs, as well as review of the classification of ECFs and EAFs, provides a framework for the suggested phased strategy that specifically targets the nutritional and metabolic needs of the ECF/EAF patient. These three phases include (1) diagnosis, resuscitation, and early interval nutrition; (2) definition of fistula anatomy, drainage of collections, nutritional assessment and monitoring, and placement of feeding access; and (3) definitive operative management. Conclusion: The successful management of GI fistula requires a multi- disciplinary team approach including a gastroenterologist, interventional radiologist, enterostomal therapist, dietician, social worker and surgeons. With this coordinated approach, EC fistula can be controlled with acceptable morbidity and mortality.
Comparison of Science and Engineering Concepts in Next Generation Science Standards with Jordan Science Standards

The purpose of this Science Standards Content Crosswalk study is to compare the degree of alignment between Next Generation Science Standards (NGSS) and Jordan’s science standards in K-8. A team of 5 science educators worked together to review each NGSS standard and decide whether there is a conceptual match for it in current Jordan science standards. Rigorous content analysis and interpretation approach was used to make decisions about matches between both sets of standards. Results revealed significant misalignments between the science learning outcomes identified by NGSS and those of Jordan. Results also showed that, Physical Sciences concepts had the highest percentage (58%) of not addressed concepts in 3-5 grade band followed by Earth and Space Sciences (42%) and Life Sciences concepts (36%). However, the highest percentage of not addressed concepts in grade band 6-8 were Earth and Space Sciences (58%) followed by Physical Sciences (46%) and Life Sciences (36%) concepts. This finding can support projections of the needs for new instructional materials and for subject-specific teachers’ professional development. The results also provide a clear direction for the newly established national center for curriculum to revise the national science standards and curricula.
A from fed a diet induces and of HepG2 cells.

trans10-18:1 enriched fraction beef barley grain-based lipogenic gene expression reduces viability Beef fat is a natural source of trans (t) fatty acids, and is typically enriched with either t 10-18:1 or t 11- 18:1. Little is known about the bioactivity of individual t -18:1 isomers, and the present study compared the effects of t 9-18:1, cis ( c )9-18:1 and trans (t) -18:1 fractions isolated from beef fat enriched with either t 10-18:1 (HT10) or t 11-18:1 (HT11). All 18:1 isomers resulted in reduced human liver (HepG2) cell viability relative to control. Both c 9-18:1 and HT11were the least toxic, t 9-18:1had dose response increased toxicity, and HT10 had the greatest toxicity ( P o 0.05). Incorporation of t 18:1 isomers was 1.8 – 2.5 fold greater in triacylglycerol (TG) than phospholipids (PL), whereas Δ 9 desaturation products were selec- tively incorporated into PL. Culturing HepG2 cells with t 9-18:1 and HT10 increased ( P o 0.05) the Δ 9 desaturation index ( c 9 – 16:1/16:0) compared to other fatty acid treatments. HT10 and t 9-18:1 also in- creased expression of lipogenic genes (FAS, SCD1, HMGCR and SREBP2) compared to control ( P o 0.05), whereas c 9-18:1 and HT11 did not affect the expression of these genes. Our results suggest effects of HT11 and c 9-18:1 were similar to BSA control, whereas HT10 and t -9 18:1 (i.e. the predominant trans fatty acid isomer found in partially hydrogenated vegetable oils) were more cytotoxic and led to greater expression of lipogenic genes.
Mechanisms and relevant genes of drug resistance in gastric cancer

Gastric cancer (GC) is one of the most common malignancies in China, and chemotherapy is an important treat ment for GC. However, drug resistance remains the main barrier to successful chemotherapy. Drug resistance is a complex phenomenon resulting from a combination of factors and mechanisms. The number of known relevant genes implicated in this phenomenon is growing rapidly. This review focuses on the mechanisms involved in the occurrence of drug resistance and explores the functions of several relevant genes in GC chemotherapy resistance.
OTT_A_230875 6339..6349

Sujie Gao Defeng Song Yiting Liu 3 Hongwei Yan Xuebo Chen 1Department of Anesthesia, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, People’s Republic of China 130033; 2Department of General Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province 130033, People’s Republic of China; 3Department of Radiology, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing 100036, People’s Republic of China; 4Department of General Surgery, Chinese Medicine Hospital, Liuhe, Jilin Province 135300, People’s Republic of China Introduction: Gastric cancer (GC) is one of the most malignancies leading to human mortality due to its development, progress, metastasis and poor prognosis, despite the development of remarkable chemotherapy and surgery. The 5-fluorouracil (5-Fu) is an effective antigastric cancer agent. However, a fraction of GC patients acquire 5-Fu chemoresistance. Methods: In this study, the CagA protein was detected from CagA-positive gastric cancer patients by qRT-PCR and immunohistochemistry. The 5-Fu resistant gastric cancer cell line was generated from MKN45-CagA cells which was transfected with CagA overexpression vector. Cellular glucose metabolism was determined by measurements of glucose uptake, lactate product and glycolysis enzymes. Results: We report that the Helicobacter pylori (H. pylori)-secreted Cytotoxin-associated gene A (CagA) oncoprotein is positively correlated with 5-Fu resistance of gastric cancer. From totally 72 CagA-positive gastric cancer patients, CagA high-expressed patients showedmore resistance to 5-Fu than CagA low-expressed patients. Moreover, statistical analysis revealed that CagA mRNA and protein expressions were significantly upregulated in 5-Fu resistant gastric cancer patients. We observed that CagA protein is upregulated in 5-Fu resistant gastric cancer cells compared with sensitive cells. Interestingly, cellular glucose metabolism was upregulated; the glucose uptake and lactate production were significantly higher in 5-Fu resistant gastric cancer cells. The Akt phosphorylation and expressions of glycolysis key enzymes, Hexokinase 2 and LDHA, were significantly upregulated in 5-Fu resistant gastric cancer cells. On the other way, inhibition of glycolysis or Akt pathway effectively overcame 5-Fu resistance from both in vitro and in vivomodels. Finally, we report that the combination of Akt or glycolysis inhibitor with 5-Fu could synergistically enhance the cytotoxicity of 5-Fu to CagA-overexpressed gastric cancer cells. Discussion: In summary, our study demonstrated a CagA-Akt-glycolysis-5-Fu resistance axis, contributing to the development of new therapeutic agents against chemoresistant human gastric cancer.
Schematic generation of characteristic polynomials and the Hosoya indices of mono- and di-substituted polymer graphs of linear chains and cycles

: The graphs of polymer chains (such as, chain with two pendant vertices at one end and chain with two pendant vertices at each end) and of cycles (such as, cycle with one pendant vertex and cycle with two adjacent pendant vertices) have been considered. Algorithms have been developed for expressing of matching polynomial (MP) coefficients of such graphs as matrix products and subsequently been utilized to express the CP coefficients (in case of monocycles) and the Hosoya indices of such graphs in matrix product forms. Facile computer programs can be made with these algorithms. Melting points (in Kelvin) and motor octane number (MON) have been found to obey linear relationship with the Hosoya indices whereas the boiling points (in Kelvin) bear a excellent linear relationship with the logarithm of Hosoya indices of two kinds of alkanes represented by the linear chains.
Extrapolation of Galactic Dust Emission at 100 Microns to Cosmic Microwave Background Radiation Frequencies Using FIRAS

We present predicted full-sky maps of submillimeter and microwave emission from the di(cid:134)use interstellar dust in the Galaxy. These maps are extrapolated from the 100 k m emission and 100/240 k m (cid:209)ux ratio maps that Schlegel, Finkbeiner, & Davis generated from IRAS and COBE /DIRBE data. Results are presented for a number of physically plausible emissivity models. The correlation of COBE /FIRAS data with the simple Schlegel, Finkbeiner, & Davis ( l 2 emissivity power law) extrapolation is much tighter than with other common dust templates such as H I column density or 100 k m emission. Despite the apparent success of the Schlegel, Finkbeiner, & Davis extrapolation, the assumed l 2 emissivity is inconsistent with the FIRAS data below 800 GHz. Indeed, no power-law emissivity function —ts the FIRAS data from 200 to 2100 GHz. In this paper we provide a formalism for a multicomponent model for the dust emission. A two-component model with a mixture of (cid:147)(cid:147) silicate ˇˇ and (cid:147)(cid:147) carbon-dominated ˇˇ grains (motivated by Pollack et al.) provides a —t to an accuracy of D 15% to all the FIRAS data over the entire high-latitude sky. Small systematic di(cid:134)erences are found between the atomic and molecular phases of the ISM. COBE /DMR has observed microwave emission that is correlated with thermal dust emission. However, this emission is higher than our model predicts by factors of 1.2, 2.4, and 20 at 90, 53, and 31 GHz, respectively. This provides evidence that another emission mechanism dominates dust emission at frequencies below D 60 GHz. Our predictions for the thermal (vibrational) emission from Galactic dust at l \ 3000 GHz are available for general use. These full-sky predictions can be made at the DIRBE resolution of 40 @ or at the higher resolution of from the Schlegel, Finkbeiner, & Davis 6 @ . 1 DIRBE-corrected IRAS maps.
A small secreted protein from Zymoseptoria tritici interacts with a wheat E3 ubiquitin to promote disease

Title A small secreted protein from Zymoseptoria tritici interacts with a wheat E3 ubiquitin to promote disease Authors(s) Karki, Sujit Jung; Reilly, Aisling; Zhou, Binbin; Mascarello, Maurizio; Burke, James; Doohan, Fiona M. ; Douchkov, Dimitar; Schweizer, Patrick; Feechan, Angela Publication date 2021-02-02 Publication information Journal of Experimental Botany, 72 (2): 733-746 Publisher Oxford University Press Item record/more information http://hdl.handle. net/10197/12757 Publisher's statement This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Publisher's version (DOI) 10.1093/jxb/eraa489
Case Report: Using Biometrics for Participant Identification in a Research Study: A Case Report

This paper illustrates the use of biometrics through the application of an iris-based biometrics system for identifying twins and their parents in a longitudinal research study. It explores the use of biometrics (science of measuring physical or anatomical characteristics of individuals) as a technology for correct identification of individuals during longitudinal studies to help ensure data fidelity. Examples of these circumstances include longitudinal epidemiological and genetic studies, clinical trials, and multicenter collaborative studies where accurate identification of subjects over time can be difficult when the subject may be young or an unreliable source of identification information. The use of technology can automate the process of subject identification thereby reducing the need to depend on subject recall during repeated visits thus helping to ensure data quality. This case report provides insights that may serve as useful hints for those responsible for planning system implementation that involves participants' authentication that would require a more secure form of identification.
The spectrum of CYP21A2 gene mutations in patients with 2l-hydroxylase deficiency -induced congenital adrenal hyperplasia in a Chinese cohort CURRENT POSTED

Background 21-hydroxylase deficiency (21-OHD) caused by the CYP21A2 gene mutations is the most popular form of congenital adrenal hyperplasia. It is an autosomal recessive disorder results in the defective synthesis of cortisol and aldosterone. The incidences of various CYP21A2 gene mutations and the genotype-phenotype correlations vary among different populations. Therefore, the aim of current study was to identify the spectrum of CYP21A2 gene mutations of patients from northern China and analyze the genotype-phenotype correlation. Methods The clinical and molecular data of 22 patients were analyzed in this study. Locus-specific polymerasechain reaction and Sanger sequencing were applied to identify gene micro-conversions, and multiplex ligation-dependent probe amplification as an alternative to Southern blotting was used to detect large fragment deletions/conversions. Then the genotypes were categorized in to Null, A, B, C and D groups to analyze the relationships between genotypes and phenotypes. Results Molecular defects were detected in 44 alleles (100%). Micro-conversion mutation IVS2-13A/C> G (70.5%) is most common in our cohort, followed by large gene deletions and conversions (22.7%). The other mutations present were p.R357W (4.5%) and E6 Cluster (2.3%). Genotypes of 22 patients (100%) were consistent with the predictive phenotypes. Conclusions In this study, we collected 22 21-OHD patients’ clinical and mutations data in Chinese population, especially in northern China. Micro-conversions were the most popular mutations and the frequencies were consistent with other cohorts. Moreover, thegenotypes and phenotypes in 21-OHDwere well correlated. This studyidentifiedthe mutation spectrum of CYP21A2gene and conduced to genetic counseling and prenatal diagnosis. of the correlation between genotypes and phenotypes, genetic for Locus-specific PCR and Sanger sequencing to point mutations,
the jixueteng against cariogenic and periodontal pathogens

a dried stem of Spatholobus suberectus is a traditional Chinese medicine, and is used to improve the circulation of the blood and to enrich the blood cells. To examine an antimicrobial eﬀect of the Jixueteng against oral bacteria, we mixed bacterial suspension of Actinomyces viscosus, Streptococcus mutans, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Veillonella parvula or Candida albicans with a water extract of the Jixueteng to calculate a survival rate by a cultural method. As the result, the Jixueteng extract exhibited antimicrobial activities for S. mutans, F. nucleatum, P. gingivalis, V. parvula, and salivary bacteria. These results suggest that ingredients of the Jixueteng extract are available for drug discovery for periodontitis.