Miracle-dz/UniFAR-FTUs huggingface dataset:
Modélisation bayésienne avec des splines du comportement moyen d'un échantillon de courbes

37 2.
Regulation of Claudin-1 Expression Via Activation of Ron Tyrosine Regulation of Claudin-1 Expression Via Activation of Ron Tyrosine Kinase and Transforming Growth Factor-Beta Signaling Pathways Kinase and Transforming Growth Factor-Beta Signaling Pathways in Ovarian Carcinoma in Ovarian Carcinoma

Epithelial ovarian carcinoma is the most common cause of death among gynecologic malignancies in the United States. In the U.S., more than 21,000 women will be diagnosed with ovarian cancer and about 15,000 women will die of the disease this year alone. Although migration and invasion play key roles in tumor progression, the specific molecular events leading to dissemination of ovarian tumor cells have not been well delineated. Tight junctions are an integral component of epithelial junction complexes, which play a vital role in maintaining epithelial integrity and cell polarity. Disruption of tight junctions is a hallmark of epithelial cancer development and malignant progression; specifically decreased claudin-1 expression has been associated with progression to tumor malignancy. Herein, we investigate the mechanism by which claudin-1 expression is regulated via activation of the TGF β and RON tyrosine kinase receptor signaling pathways. We propose that claudin-1 expression is regulated by the activation of the TGF β signaling pathway (dysregulated in ovarian carcinomas), particularly SnoN/SkiL, a key TGF β co-repressor. In ovarian carcinoma cells, we observed that treatment with TGF β and MSP1 led to a marked reduction in claudin-1 protein expression. Further, we not only noted that siRNA targeting RON led to upregulated claudin-1 mRNA and protein expression, but similar changes in mRNA and proteins of claudin-1 were observed with SnoN and β -catenin knockdown. Strikingly, with β -catenin knockdown, SnoN levels were notably decreased suggesting that β -catenin could potentially regulate SnoN expression. Collectively, our results demonstrate that claudin-1 expression is regulated by the transcriptional regulators β -catenin and SnoN. Since identification of novel biomarkers could be beneficial in diagnosis, prognosis and prediction of patient outcomes, these observations regarding the cellular events underlying regulation of claudin-1 expression are of translational potential.
Majordomo : How I Manage 17 Mailing Lists Without Answering "-request" Mail

Majordomo is a perl program written to handle routine administration of Internet mailing lists with as little human intervention as possible. Modeled after the Listserv implementations common on BITNET (but unfortunately rare on the Internet), it automates the administration of mailing lists by allowing users to perform the most frequent operations ("subscribe" and "unsubscribe") themselves, while allowing the list owners to either "approve" each of these operations (or initiate them on behalf of a user), or merely monitor them as they are automatically approved. It also automates response to certain other common queries from users, such as "what lists are served by this Majordomo server? ", "what is the topic of list ’foobar’? ", "who is already on list ’foobar’? ", and "which lists managed by this Majordomo server am I already on? ". Majordomo allows individual list owners to manage their own lists (subscribe and unsubscribe users, and change the general information message for their list) without any action by the overall Majordomo owner. It serves both "open" lists (where users can add themselves to the list, and the list owner is merely informed of this action) and "closed" lists (where a subscription request from a user generates an approval request from the Majordomo server to the list owner, who can then either approve or ignore the request). Finally, all interactions with Majordomo by both users and list owners take place totally by electronic mail, so users and list owners do not require login access (nor even direct TCP/IP connectivity) to the machine Majordomo is running on, and no special client software is required.
Considerations about the implementation of a public knowledge base regarding nanotechnology

Nanotechnology ranks among the key technologies that will bring fundamental changes to basic research, many industry sectors and daily life. However, consumers often miss reliable and understandable information on nanomaterials. To create this transparency, the DaNa project collects and evaluates the latest scientific literature before publishing these on the website www.nanoobjects. info. Though all published articles are designed to meet the needs of different recipient groups, a certain knowledge about nanomaterials is presumed due to the nanomaterial-specific structuring of the website. This poses a barrier for interested laymen who usually have a particular nano-related application in mind. These application-oriented facts on nanomaterials already exist on the website but are scattered throughout the different articles. To overcome this, we first analyzed the state of the scattered information and then assessed requirements for a new tool displaying these facts: storage of extracted knowledge in a homogenous way, visualization options and integration of the new database into the existing content management system. We therefore extended our backend to capture knowledge on a semantically higher level in a database called DaNaVis. Based on this database we can increase the accessibility of DaNa's project results by means of interactive visualization components.
Investigation of Creativity Thinking and Problem Solving Skills of Candidate Pre-and Primary School Teachers

Özet: Bu çalışmada okul öncesi ve sınıf öğretmen adaylarının yaratıcı düşünme ve problem çözme becerilerinin çeşitli değişkenler açısından incelenmesi amaçlanmıştır. Araştırmada nicel araştırma yöntemlerinden betimsel tarama yöntemi kullanılmıştır. Araştırmanın evrenini, Atatürk Üniversitesi Kazım Karabekir Eğitim Fakültesi İlköğretim Bölümü Okul Öncesi Eğitimi ve Sınıf Öğretmenliği Ana Bilim Dallarında öğrenim gören öğretmen adayları oluşturmaktadır. Araştırmada seçkisiz olmayan örnekleme yöntemlerinden amaçsal örnekleme kullanılmış olup, araştırmanın örneklemi söz konusu ana bilim dallarında 1. sınıf ve 4. sınıfta öğrenim görmekte olan 409 öğretmen adayı oluşturmaktadır. Araştırmada veri toplama aracı olarak, öğrencilerin yaratıcılıklarını belirlemek amacıyla Whetton ve Cameron’dan (2002) tarafından geliştirilen ve Türkçe’ye uyarlaması ve geçerlik güvenirlik çalışmaları Aksoy (2004) tarafından yapılan “Ne kadar yaratıcısınız? ” ölçeği ve problem çözme becerilerini ölçmek amacıyla Heppner ve Petersen (1982) tarafından geliştirilerek, Taylan (1990) tarafından Türkçe’ye uyarlanan “Problem çözme envanteri” (PÇE) kullanılmıştır. Bulgulara bakıldığında, öğretmen adaylarının yaratıcı düşünme becerilerinin cinsiyet, öğrenim görülen ana bilim dalı, sınıf ve mezun olunan lise türü değişkenlerine göre anlamlı bir şekilde farklılaştığı görülürken; problem çözme becerilerinin ise sadece cinsiyet değişkenine göre anlamlı bir şekilde farklılaştığı görülmüştür. Ayrıca öğretmen adaylarının yaratıcı düşünme ve problem çözme becerileri arasında orta düzeyle ve pozitif yönde anlamlı bir ilişki olduğu görülmüştür.
UN CRANE DE CHALICOTHERE (MAMMALIA, PERISSODACTYLA) DU MIO CENE SUPERIEUR DE MACEDOINE (GRECE): REMARQUES SUR LA PHYLOGENIE DES CHALICOTHERIINAE

SOMMAIRE Page Resume, Summary. 136 Introduction 137 Macrotherium macedollicum n. sp. 138 Calvarium . 138 Description 138 Vue superieure . 139 Vue laterale. 139 Vue posterieure. 139 Vue ventrale. 140 Comparaisons. 142 "Macrotherium" brevirostris de Tung Gur 142 Macrotherium grande de Sansan . 143 Macrotherium grande de Neudorf . 144 Crâne de La Grive Saint-Alban (Isere) . 145 Maxillaire de Saint Gaudens. 145 Fragment de crâne de Vathylakkos. 147 Mandibule. 147 Description 147 Comparaisons. 147
Perceived barriers to partner notification among sexually transmitted infection clinic patients, Cape Town, South Africa

Background Public health approaches to sexually transmitted infection (STI) prevention in resource-limited countries rely on patients to self-notify sex partners of their STI. However, a majority of partners go uninformed and remain untreated and infectious. Methods Anonymous surveys collected from 776 men and women receiving STI clinic services in Cape Town, South Africa. Results Half of patients surveyed intended to inform their partners, while half did not intend to notify partners. Women were more likely than men to intend to notify their partners. Patients who completed formal education were also more likely to indicate intentions to notify partners. There were no associations between numbers of partners patients had or partner types with intentions to notify partners. Among both men and women, concerns about adverse partner reactions were associated with intentions not to notify partners. Multivariable analyses stratified by gender and controlling for confounds showed that intentions to notify partners were significantly related to men's concerns that their partner could react violently against them and women's concerns that their partner may leave them and refuse to see them again. Conclusions Interventions that assist patients to develop strategies to safely inform their partners are needed to increase patient-initiated partner notification.
Apples and Cardiovascular Health—Is the Gut Microbiota a Core Consideration?

There is now considerable scientific evidence that a diet rich in fruits and vegetables can improve human health and protect against chronic diseases. However, it is not clear whether different fruits and vegetables have distinct beneficial effects. Apples are among the most frequently consumed fruits and a rich source of polyphenols and fiber. A major proportion of the bioactive components in apples, including the high molecular weight polyphenols, escape absorption in the upper gastrointestinal tract and reach the large intestine relatively intact. There, they can be converted by the colonic microbiota to bioavailable and biologically active compounds with systemic effects, in addition to modulating microbial composition. Epidemiological studies have identified associations between frequent apple consumption and reduced risk of chronic diseases such as cardiovascular disease. Human and animal intervention studies demonstrate beneficial effects on lipid metabolism, vascular function and inflammation but only a few studies have attempted to link these mechanistically with the gut microbiota. This review will focus on the reciprocal interaction between apple components and the gut microbiota, the potential link to cardiovascular health and the possible mechanisms of action.
Wind turbine wake aerodynamics

The aerodynamics of horizontal axis wind turbine wakes is studied. The contents is directed towards the physics of power extraction by wind turbines and reviews both the near and the far wake region. For the near wake, the survey is restricted to uniform, steady and parallel flow conditions, thereby excluding wind shear, wind speed and rotor setting changes and yawed conditions. The emphasis is put on measurements in controlled conditions. For the far wake, the survey focusses on both single turbines and wind farm effects, and the experimental and numerical work are reviewed; the main interest is to study how the far wake decays downstream, in order to estimate the effect produced in downstream turbines. The article is further restricted to horizontal axis wind turbines and excludes all other types of turbines. r 2003 Elsevier Ltd. All rights reserved. duction . 468 view . 469 wake experiments . 470 Global properties . 473 Flow visualisations . 473 Averaged data . 476 Detailed data . 476 3.4. 1. Velocities . 477 3.4. 2. Tip vortex properties . 478 wake computations . 480 The Navier–Stokes equations . 481 Vortex wake modelling . 482 Generalized actuator disc models . 484 Navier–Stokes methods . 487 4.4. 1. Turbulence modelling . 488 4.4. 2. Laminar–turbulent transition . 488 g author. Tel. : +31-15-2785166; fax: +31-15-2785347. ses: n.vermeer@citg.tudelft. nl (L.J. Vermeer), jns@mek.dtu. dk (J.N. S^rensen), crespo@enerflu.etsii. upm.es front matter r 2003 Elsevier Ltd. All rights reserved. 6-0421(03)00078-2
Performance analysis of fast convolution based FBMC-OQAM system

Filter Bank based Multicarrier (FBMC) system is a multicarrier scheme that has recently gained attention due to its better spectral properties compared to OFDM systems. FBMC system is one among the strong contenders for 5G implementations. While better designs of FBMC systems are evolving with time, it is imperative that the hardware complexity is not overlooked. It is important that filter bank designs with reduced computational resources are sought. Reducing computational complexity offers advantages like less power consumption, faster computations and reduced runtime resources. These advantages have more significance in 5G where ultra high speed and ultra low latency are the highlights. Filter bank designs using fast convolution employ less arithmetic resources compared to polyphase filter bank implementations. The fast convolution filter design makes use of only filter's frequency domain sample values for filtering since the filtering is restricted to frequency domain. So the conventional polyphase implementation of filter is completely done away with. In this paper, we present FBMC/OQAM system using Fast Convolution and the performance of the system is evaluated in a communication channel. The system is compared with conventional polyphase FBMC/OQAM system and it is found that fast convolution based system outperforms polyphase implementation of FBMC system in computational complexity and BER performance.
Design, crystal structures and magnetic properties of anionic salts containing fullerene C₆₀ and indium(III) bromide phthalocyanine radical anions.

Two salts containing fullerene C60 and indium(III) bromide phthalocyanine (Pc) radical anions have been obtained as single crystals: (TBA(+))3(C60˙(-)){In(III)(Br)(Pc)˙(-)}(Br(-))·C6H4Cl2 (1) and (TEA(+))2(C60˙(-)){In(III)(Br)(Pc)˙(-)}·C6H4Cl2·C6H14 (2) where TBA(+) and TEA(+) are tetrabutyl- and tetraethylammonium cations, respectively. The presence of both radical anions is supported by spectra of 1 and 2 in the NIR and IR-ranges. The salts contain zigzag C60˙(-) chains with 10.136 and 10.383 Å center-to-center (ctc) distances in 1 and a uniform ctc distance of 10.186 Å in 2. In 1, the C60˙(-) radical anions are dimerized in the 180-140 K range to form singly bonded (C60(-))2 dimers, whereas they remain monomeric in 2. Effective packing of planar In(Br)(Pc)˙(-) and spherical C60˙(-) is attained by introducing fullerene spheres between the phenylene substituents of Pc allowing the formation of multiple van der Waals contacts between them. The effective magnetic moment of 1 at 300 K is 2. 35μ(B), indicating a contribution of both C60˙(-) and In(Br)(Pc)˙(-) species having S = 1/2 spin state. There is strong antiferromagnetic coupling of spins between fullerenes in the chains and fullerenes and phthalocyanines in the monomeric phase of 1 with the Weiss temperature of -120 K in the 300-180 K range. The formation of diamagnetic (C60(-))2 dimers switches off magnetic coupling and magnetically isolates In(Br)(Pc)˙(-) (Weiss temperature is only -1 K in the 140-10 K range). Magnetic behavior of 2 is described by the Curie-Weiss law with weak ferromagnetic coupling of spins with Θ = +7.6 K in the 50-300 K range. Both salts manifest single Lorentzian EPR lines at room temperature with g = 1.9911 and a linewidth (ΔH) of 25.4 mT (1) and g = 1.9956 and ΔH = 7.5 mT (2) which can be attributed to both C60˙(-) and In(Br)(Pc)˙(-) species having strong exchange interaction. An asymmetric signal with the main component at g = 1.989-1.965 in the dimeric phase of 1 was attributed to the In(Br)(Pc)˙(-) radical anions.
The ordering of events in a prototyping platform

The performance of software-based verification strategies is not keeping up with the increasing complexity of modern system-on-chip (SoC) designs. Therefore modular prototyping platforms are proposed to validate SoC designs. Most of these platforms consist of real processors combined with programmable logic, e.g. FPGA, that communicate through a board-level interconnect system. Usually, the programmable logic and the interconnect system do not run at the target clock speed of the future design. Hence, the emulated processes of the prototyping platform have to be synchronized to provide an accurate system validation. Most synchronization concepts are only able to synchronize the process data flows if data is time-independent. In this paper we present an event-based prototyping platform consisting of real processors combined with FPGAs. This platform emulates events with cycle accuracy, even though the processes operate in different scaled clock domains. Therefore we are able to validate time-dependent data flows.
Upgrades to the Flagstaff Astrometric Scanning Transit Telescope: A Fully Automated Telescope for Astrometry

The Flagstaff Astrometric Scanning Transit Telescope (FASTT) is a fully automated telescope that takes about 41,000 CCD frames of data a year for various research projects. All aspects of the telescope's operation have been automated (e.g., target selection, observing, reduction of data, and collation of results), and manpower needs are now under one person per year, mostly involved with routine maintenance and the dissemination of data. This paper describes the FASTT instrumental system, methods used with its automated operation, and the various FASTT research projects. Among the projects, astrometry is provided in support of various spacecraft missions, to predict occultation events, calculate dynamical masses for selective asteroids, and improve the ephemerides for thousands of asteroids, the planets Jupiter to Pluto, and 17 satellites of Jupiter through Neptune. Although most of the FASTT observing program involves the solar system, FASTT stellar astrometry was used to set up a number of astrometric calibration regions along the celestial equator, verify the Hipparcos link to the International Celestial Reference Frame, determine accurate positions for a large sample of radio stars, and investigate systematic errors in the FK5 star catalog. Furthermore, the FASTT produces accurate magnitudes that are being used to investigate the shapes of thousands of asteroids. By the end of year 2003, the FASTT will have produced over 190,000 positions of solar system objects in a program to provide a very large and homogeneous database for each object that will extend over many years and include positions accurate to ±47 to ±300 mas, depending on the magnitude of each observed object (3.5 < V < 17.5). Moreover, extensive efforts have been undertaken to improve the systematic accuracy of FASTT equatorial positions by applying corrections in the reductions for differential color refraction, distortions in the focal plane, and correcting for a positional error that is dependent on magnitude. The systematic accuracy of FASTT observations is now about ±20 mas in both right ascension and declination. FASTT data have contributed very significantly to recent successful spacecraft missions and to a dramatic improvement in the predictions made for occultation events.
The no-slip boundary condition: a review

2 History of the no-slip condition 2 2.1 The previous centuries . 2 2.2 Terminology . 3 2.3 Traditional situations where slip occurs . 3 2.4 Newtonian liquids: no-slip? slip? 4
Replacement of oral proton pump inhibitors with intravenous pantoprazole to effectively control gastric acid hypersecretion in patients with Zollinger-Ellison syndrome

OBJECTIVES:In patients with Zollinger-Ellison syndrome (ZES) or other conditions requiring oral doses of proton pump inhibitors, it frequently becomes necessary to use parenterally administered gastric acid inhibitors. However, i.v. histamine-2 receptor antagonists are not effective at usual doses and lose their effectiveness because of tachyphlaxis. With the approval in the United States of i.v. pantoprazole, a substituted benzimidazole available in i.v. formulation, it will become possible to acutely manage gastric acid secretion in the acute care setting of a hospital. This study was developed to monitor the safety and establish the efficacy of i.v. pantoprazole as an alternative to oral proton pump inhibitors for the control of gastric acid hypersecretion in patients with ZES.METHODS:The efficacy of replacing oral PPI therapy with i.v. pantoprazole was evaluated in 14 ZES patients. After study enrollment, patients taking their current doses of oral PPI (omeprazole or lansoprazole) were switched to pantoprazole i.v. for 6 days during an 8-day inpatient period in the clinical research center. Effective control was defined as an acid output (AO) of <10 mEq/h (<5 mEq/h in patients with prior gastric acid-reducing surgery). RESULTS:The mean age of the 14 patients enrolled in the study was 52.4 yr (range = 38–67). Mean basal AO was 0.55 ± 0.32 mEq/h and mean fasting gastrin was 1089 pg/ml (range = 36–3720). Four patients were also diagnosed with the multiple endocrine neoplasia type I syndrome, nine were male, and two had previously undergone acid-reducing surgery. Before study enrollment, gastric acid hypersecretion was controlled in nine of 14 patients with omeprazole (20–200 mg daily) and five of 14 with lansoprazole (30–210 mg daily). In the oral phase of the study all patients had adequate control of gastric acid secretion, with a mean AO of 0.55 ± 0.32 mEq/h (mean ± SEM). Thereafter, 80 mg of i.v. pantoprazole was administered b.i. d. for 7 days by a brief (15 min) infusion and the dose was titrated upward to a predetermined maximum of 240 mg/24 h to control AO. A dose of 80 mg b.i. d. of i.v. pantoprazole controlled AO in 13 of 14 of the patients (93%) for the duration of the study (p > 0.05 compared to baseline values for all timepoints). One sporadic ZES patient (oral control value = 0.65 mEq/h on 100 mg of omeprazole b.i.d. p.o.) was not controlled with 80 mg of i.v. pantoprazole b.i. d. and dosage was titrated upward to 120 mg b.i. d. after day 2.CONCLUSIONS:There were no serious adverse events observed. Intravenous pantoprazole provides gastric acid secretory control that is equivalent to the acid suppression observed with oral proton pump inhibitors. Most ZES patients (93%) maintained effective control of AO previously established with oral PPIs when switched to 80 mg of i.v. pantoprazole b.i. d. ; however, for difficult-to-control patients, doses >80 mg b.i. d. may be required.
Distance Metric Learning with Application to Clustering with Side-Information

Many algorithms rely critically on being given a good metric over their inputs. For instance, data can often be clustered in many "plausible" ways, and if a clustering algorithm such as K-means initially fails to find one that is meaningful to a user, the only recourse may be for the user to manually tweak the metric until sufficiently good clusters are found. For these and other applications requiring good metrics, it is desirable that we provide a more systematic way for users to indicate what they consider "similar. " For instance, we may ask them to provide examples. In this paper, we present an algorithm that, given examples of similar (and, if desired, dissimilar) pairs of points in ℝn, learns a distance metric over ℝn that respects these relationships. Our method is based on posing metric learning as a convex optimization problem, which allows us to give efficient, local-optima-free algorithms. We also demonstrate empirically that the learned metrics can be used to significantly improve clustering performance.