Miracle-dz/UniFAR-FTUs huggingface dataset:
Early-start antiplatelet therapy after operation in patients with spontaneous intracerebral hemorrhage and high risk of ischemic events (E-start): Protocol for a multi-centered, prospective, open-label, blinded endpoint randomized controlled trial

Background For severe spontaneous intracerebral hemorrhage (sSICH) patients with high risk of ischemic events, the incidence of postoperative major cardiovascular/cerebrovascular and peripheral vascular events (MACCPE) is notable. Although antiplatelet therapy is a potential way to benefit these patients, the severe hemorrhagic complications, e.g., intracranial re-hemorrhage, is a barrier for early starting antiplatelet therapy. Objectives This randomized controlled trial aims to identify the benefit and safety of early starting antiplatelet therapy after operation for sSICH patients with high risk of ischemic events. Methods This study is a multicenter, prospective, randomized, open-label, blinded-endpoint trial. We will enroll 250 sSICH patients with a high risk of ischemic events (including cerebral infarcts, transient ischemic attack, myocardial infarction, pulmonary embolism, and deep venous thrombosis). The participants will be randomized in a 1:1 manner to early-start group (start antiplatelet therapy at 3 days after operation) and normal-start group (start antiplatelet therapy at 30 days after operation). The early-start group will receive aspirin 100 mg daily. The control group will not receive antithrombotic therapy until 30 days after operation. The efficacy endpoint is the incidence of MACCPE, and the safety endpoint is the incidence of intracranial re-hemorrhage. Discussion The Early-Start antiplatelet therapy after operation in patients with spontaneous intracerebral hemorrhage trial (E-start) is the first randomized trial about early start antiplatelet therapy for operated sSICH patients with a high risk of ischemic events. This study will provide a new strategy and evidence for postoperative management in the future. Clinical trial registration ClinicalTrials.gov, identifier NCT04820972; Available at: https://clinicaltrials.gov/ct2/show/NCT04820972? term=NCT04820972&draw=2&rank=1. Chinese Clinical Trial Registry, identifier ChiCTR2100044560; Available at: http://www.chictr. org.cn/showproj.aspx? proj=123277.
Analytic Scattering Theory for Jacobi Operators and Bernstein–Szegö Asymptotics of Orthogonal Polynomials

We study semi-infinite Jacobi matrices [Formula: see text] corresponding to trace class perturbations [Formula: see text] of the “free” discrete Schrödinger operator [Formula: see text]. Our goal is to construct various spectral quantities of the operator [Formula: see text], such as the weight function, eigenfunctions of its continuous spectrum, the wave operators for the pair [Formula: see text], [Formula: see text], the scattering matrix, the spectral shift function, etc. This allows us to find the asymptotic behavior of the orthonormal polynomials [Formula: see text] associated to the Jacobi matrix [Formula: see text] as [Formula: see text]. In particular, we consider the case of [Formula: see text] inside the spectrum [Formula: see text] of [Formula: see text] when this asymptotic has an oscillating character of the Bernstein–Szegö type and the case of [Formula: see text] at the end points [Formula: see text].
Alternative strategies for Chlamydia treatment: Promising non-antibiotic approaches

Chlamydia is an obligate intracellular bacterium where most species are pathogenic and infectious, causing various infectious diseases and complications in humans and animals. Antibiotics are often recommended for the clinical treatment of chlamydial infections. However, extensive research has shown that antibiotics may not be sufficient to eliminate or inhibit infection entirely and have some potential risks, including antibiotic resistance. The impact of chlamydial infection and antibiotic misuse should not be underestimated in public health. This study explores the possibility of new therapeutic techniques, including a review of recent studies on preventing and suppressing chlamydial infection by non-antibiotic compounds.
On the dynamics of Translated Cone Exchange Transformations

In this paper we investigate translated cone exchange transformations, a new family of piecewise isometries and renormalize its first return map to a subset of its partition. As a consequence we show that the existence of an embedding of an interval exchange transformation into a map of this family implies the existence of infinitely many bounded invariant sets. We also prove the existence of infinitely many periodic islands, accumulating on the real line, as well as non-ergodicity of our family of maps close to the origin.
On Borel maps, calibrated ${\ensuremath {\sigma }}$-ideals, and homogeneity

Let $\mu$ be a Borel measure on a compactum $X$. The main objects in this paper are $\sigma$-ideals $I(dim)$, $J_0(\mu)$, $J_f(\mu)$ of Borel sets in $X$ that can be covered by countably many compacta which are finite-dimensional, or of $\mu$-measure null, or of finite $\mu$-measure, respectively. Answering a question of J. Zapletal, we shall show that for the Hilbert cube, the $\sigma$-ideal $I(dim)$ is not homogeneous in a strong way. We shall also show that in some natural instances of measures $\mu$ with non-homogeneous $\sigma$-ideals $J_0(\mu)$ or $J_f(\mu)$, the completions of the quotient Boolean algebras $Borel(X)/J_0(\mu)$ or $Borel(X)/J_f(\mu)$ may be homogeneous. We discuss the topic in a more general setting, involving calibrated $\sigma$-ideals.
Box fermentation and solar drying improve the nutrient composition and organoleptic quality of chocolate from cocoa beans

Chocolate is a well-liked and popular food product made from the cocoa bean. The objective of this research was to evaluate the effects of box fermentation and solar drying of cocoa bean on chocolate quality. Fermentation was carried out in a perforated wooden box for 168 h with periodic turning after every 48 h. The succession of microorganisms during fermentation and total microbial count were monitored. Both the fermented and unfermented samples were solar dried. During drying the change in weight of the beans, amount of solar radiation, and ambient wind speed of the atmosphere were measured. The approximate nutrient (crude protein, crude fat, total ash, crude fiber, and carbohydrate) and phytochemical (phenol) contents of the dried cocoa beans were evaluated. Sensory properties of chocolate, produced from the two samples (box fermented and dried as well as unfermented and dried) were compared. The initial temperature of the fermenting cocoa mash was 30°C. It rose to 46°C by the 96th h of fermentation and sharply declined to 38°C by the 120th h. Candida, Pseudomonas and Staphylococcus spp were probable organisms identified with the fermenting mass at the initial stage of the fermentation. Lactic acid bacteria dominated after 72 h. Bacillus spp was also observed until the 168th h. Solar drying of unfermented bean lasted for 4 days, while that of fermented bean lasted for 3 days. Fermentation increased the crude protein, total ash and carbohydrate contents of the cocoa beans. It also improved the appearance, and aroma of chocolate from the cocoa beans. Graphical Abstract Production of chocolate from the coco bean.
Ureteropelvic junction obstruction in infants: Open or minimally invasive surgery? A systematic review and meta-analysis

Introduction The historical gold standard treatment for ureteropelvic junction obstruction (UPJO) was the open Anderson–Hynes dismembered pyeloplasty (OP). Minimally invasive surgery (MIS) procedures, including laparoscopic pyeloplasty (LP) and robot-assisted laparoscopic pyeloplasty (RALP), have been reported to achieve better outcomes (i.e., decreased morbidity, reduced postoperative pain, superior esthetic results, and shortened length of hospital stay, LOS), with a success rate similar to OP. The main limitation of the MIS approach is the age and weight of patients, limiting these procedures to children >1 year. This study aims to evaluate the feasibility and benefits of MIS pyeloplasty compared to OP to surgically treat UPJO in children <1 year of age. Materials and methods A systematic review was independently performed by two authors. Papers comparing both techniques (MIS pyeloplasty vs. OP) in infants were included in the meta-analysis. Data (mean ± DS or percentage) were analyzed using Rev.Man 5.4 A p < 0.05 was considered significant. Results Nine studies (eight retrospective and one prospective) meet the inclusion criteria. A total of 3,145 pyeloplasties have been included, with 2,859 (90.9%) OP and 286 (9.1%) MIS. Age at operation was 4.9 ± 1.4 months in OP vs. 5.8 ± 2.2 months in MIS, p = ns. Weight at surgery was 6.4 ± 1.4 kg in OP vs. 6.9 ± 1.4 kg in MIS, p = ns. Operative time was 129.4 ± 24.1 min for OP vs. 144.0 ± 32.3 min for MIS, p < 0.001. LOS was 3.2 ± 1.9 days for OP vs. 2.2 ± 0.9 days for MIS, p < 0.01. Postoperative complications were present in 10.0 ± 12.9% of OP vs. 10.9 ± 11.6% in MIS, p = ns. Failure of surgery was 5.2 ± 3.5% for OP vs. 4.2 ± 3.3% for MIS, p = ns. Conclusion The development of miniaturized instruments and technical modifications has made MIS feasible and safe in infants and small children. MIS presented a longer operative time than OP. However, MIS seemed effective for treating UPJO in infants, showing shortened LOS compared to OP. No differences have been reported with regard to the incidence of postoperative complications and failure of pyeloplasty. Given the low quality of evidence of the meta-analysis according to the GRADE methodology, we would suggest limiting MIS procedures in infants to only those high-volume centers with experienced surgeons.
ZNF24 regulates the progression of KRAS mutant lung adenocarcinoma by promoting SLC7A5 translation

Background Clinical treatment of RAS mutant cancers is challenging because of the complexity of the Ras signaling pathway. SLC7A5 is a newly discovered downstream gene of the Ras signaling pathway, but the regulatory mechanism is unclear. We aimed to explore the molecular mechanism and role in KRAS mutant lung adenocarcinoma progression. Methods Key gene that regulated SLC7A5 in KRAS mutant lung adenocarcinoma was screened by RNA sequencing and bioinformatics analysis. The effect of this gene on the expression of SLC7A5 was studied by RNAi. The regulatory mechanism between the two genes was investigated by immunofluorescence, CoIP, pulldown and yeast two-hybrid assays. The location of the two genes was determined by inhibiting Ras and the downstream pathways PI3K-AKT and MEK-ERK. By in vivo and in vitro experiments, the effects of the key gene on the biological functions of KRAS mutant lung adenocarcinoma were explored. Results We found a novel gene, ZNF24, which upregulated SLC7A5 protein expression rather than mRNA expression in KRAS mutant lung adenocarcinoma. Endogenous protein interactions occurred between ZNF24 and SLC7A5. Ras inhibition reduced the expression of ZNF24 and SLC7A5. ZNF24 and SLC7A5 are located downstream of the MEK-ERK and PI3K-AKT pathways. In vivo and in vitro functional experiments confirmed that the ZNF24-SLC7A5 signaling axis promoted the proliferation, invasion and migration of KRAS mutant lung adenocarcinoma. Conclusions ZNF24 promoted the growth of KRAS mutant lung adenocarcinoma by upregulating SLC7A5 protein expression, which suggested that ZNF24 is a new biomarker of KRAS mutant tumors and could be a new potential therapeutic target for Ras-driven tumors.
A GHKNN model based on the physicochemical property extraction method to identify SNARE proteins

There is a great deal of importance to SNARE proteins, and their absence from function can lead to a variety of diseases. The SNARE protein is known as a membrane fusion protein, and it is crucial for mediating vesicle fusion. The identification of SNARE proteins must therefore be conducted with an accurate method. Through extensive experiments, we have developed a model based on graph-regularized k-local hyperplane distance nearest neighbor model (GHKNN) binary classification. In this, the model uses the physicochemical property extraction method to extract protein sequence features and the SMOTE method to upsample protein sequence features. The combination achieves the most accurate performance for identifying all protein sequences. Finally, we compare the model based on GHKNN binary classification with other classifiers and measure them using four different metrics: SN, SP, ACC, and MCC. In experiments, the model performs significantly better than other classifiers.
Yap1-mediated Flr1 expression reveals crosstalk between oxidative stress signaling and caffeine resistance in Saccharomyces cerevisiae

Caffeine, a methylxanthine derivative, affects various physiological conditions such as cell growth, proliferation, and energy metabolism. A genome-wide screening for genes required for caffeine resistance in Schizosaccharomyces pombe revealed several candidates, including Pap1 and downstream target genes involved in caffeine efflux. We found that Yap1, a budding yeast AP-1 homolog required for oxidative stress response, has a caffeine tolerance function. Although the Yap1 mutant is not sensitive to caffeine, overexpression of Yap1 renders cells resistant to high concentrations of caffeine. Caffeine sensitivity of mutants lacking two multidrug transporters, Pdr5 or Snq2, is completely recovered by Yap1 overexpression. Among Yap1-dependent target genes, FLR1, a fluconazole-resistant gene, is necessary but not sufficient for caffeine tolerance. Low concentrations of hydrogen peroxide induce Yap1 activation, which restores cell viability against caffeine toxicity. Intriguingly, oxidative stress-mediated cellular adaptation to caffeine toxicity requires Yap1, but not Flr1. Moreover, caffeine is involved in reduction of intracellular reactive oxygen species (ROS), as well as mutation rate and Rad52 foci formation. Altogether, we identified novel reciprocal crosstalk between ROS signaling and caffeine resistance.
USDA’s revised biotechnology regulation’s contribution to increasing agricultural sustainability and responding to climate change

Biotechnology can provide a valuable tool to meet UN Sustainable Development Goals and U.S. initiatives to find climate solutions and improve agricultural sustainability. The literature contains hundreds of examples of crops that may serve this purpose, yet most remain un-launched due to high regulatory barriers. Recently the USDA revised its biotechnology regulations to make them more risk-proportionate, science-based, and streamlined. Here, we review some of the promising leads that may enable agriculture to contribute to UN sustainability goals. We further describe and discuss how the revised biotechnology regulation would hypothetically apply to these cases.
Adaptive composite learning dynamic surface control for chaotic fractional-order permanent magnet synchronous motors

This paper aims to address the tracking problem of uncertain fractional-order permanent magnet synchronous motors with parametric uncertainties. To guarantee the system stability and offset the effect of parametric uncertainties, an adaptive backstepping composite learning neural control scheme based on interval excitation is presented. Moreover, dynamic surface technique is exploited to overcome the technical limitation of “explosion of complexity” caused by standard backstepping framework. In virtue of stability analysis and illustrative simulation, it is confirmed that the proposed control scheme not only attenuates the tracking error as small as possible, but also achieves satisfactory parametric convergence with high estimation precision.
(In)frequently asked questions: On types of frequency and their role(s) in heritage language variability

In recent years, researchers have become increasingly interested in exploring frequency as a source of variability in heritage speakers’ (HSs) knowledge of their heritage language (HL). While many of these studies acknowledge that frequency can affect the shape of HL grammars, there is still no clear consensus about (a) what “frequency” means in the context of HL acquisition and (b) how to operationalize its multiple subtypes. In this paper, we provide a critical overview of frequency effects in HL research and their relevance for understanding patterns of inter/intra-speaker variability. To do so, we outline how prior research has defined, measured, and tested frequency, and present—as well as evaluate—novel methodological approaches and innovations recently implemented in the study of frequency effects, including a new analysis of how self-reported lexical frequency reliably predicts HSs’ production of subjunctive mood in Spanish. Our aim is to highlight the immense potential of such work for addressing long-standing questions about HL grammars and to propose new lines of inquiry that will open up additional pathways for understanding HL variability.
Perceived partial social integration, levels of distress and resilience, and COVID-19 vaccine rejection of Jewish and Arab citizens of Israel

Introduction The present study examines the role of perceived partial social integration (PPSI) in determining the rejection of the COVID-19 vaccine of Jewish and Arab citizens of Israel. Methods The research hypotheses are examined using a relatively large sample of the Israeli public, including 208 Arab and 600 Jewish adults, who have responded to an anonymous questionnaire pertaining, among other issues, to partial social integration and the individual level of vaccine uptake. Results Higher levels of PPSI were found to be associated with higher levels of vaccine rejection, in both Jewish and Arab samples. The Arab minority group regards themselves as less socially integrated into the Israeli society and therefore rejects the COVID-19 vaccine to a greater extent than the majority group. The Arab respondents expressed a higher level of psychological distress and a lower level of resilience compared with the Jewish participants. The perceived partial social integration score significantly predicted the levels of distress and resilience of the Jewish but not the Arab sample. Discussion The study indicates that increasing the vaccination rates depends more substantially on trust in the authorities than on leveraging greater pressure on individuals that reject the vaccine. Increased trust in the authorities and regarding oneself as an integral component of society are two vital conditions for vaccine acquiescence. Insufficient social integration is a major reason for vaccine rejection.
Identification of LTBP2 gene polymorphisms and their association with thoracolumbar vertebrae number, body size, and carcass traits in Dezhou donkeys

The number of thoracolumbar vertebrae in Dezhou donkeys varies from 22 to 24 and is associated with body size and carcass traits. In mammals, the latent transforming growth factor beta binding protein 2 (LTBP2) has been found to have some functions in the development of thoracolumbar vertebrae. The relationship between LTBP2 and TLN (the number of thoracolumbar vertebrae) of Dezhou donkeys is yet to be reported. The purposes of this study are as follows: 1) to quantify the effect of thoracolumbar vertebrae number variation of Dezhou donkeys on body size and carcass trait; 2) to study the distribution of single nucleotide variants (SNVs) in the LTBP2 gene of Dezhou donkeys; and 3) to explore whether these SNVs can be used as candidate sites to study the mechanism of Dezhou donkey muti-thoracolumbar vertebrae development. The TLN, body size, and carcass traits of 392 individuals from a Dezhou donkey breed were recorded. All animals were sequenced for LTBP2 using GBTS liquid chip and 16 SNVs were used for further analysis. We then analyzed the relationship between these SNVs with TLN, body size, and carcass traits. The results showed that: 1) c.5547 + 860 C > T, c.5251 + 281 A > C, c.3769 + 40 C > T, and c.2782 + 3975 A > G were complete genetic linkages and significantly associated with thoracic vertebrae number (TN) (p < 0.05) (wild-type homozygotes had more TN than heterozygotes); 2) c.1381 + 768 T > G and c.1381 + 763 G > T were significantly associated with lumber vertebrae number (LN) (p < 0.05); 3) c.1003 + 704 C > T, c.1003 + 651 C > T, c.1003 + 626 A > G, and c.812 + 22526 T > G were significantly associated with chest circumference (CHC), front carcass weight (CWF), after carcass weight (CWA), and carcass weight (CW) (p < 0.05) (wild-type homozygotes were larger than other genotypes in CHC, CWF, CWA, and CW); and 4) the effect of variation is not consistent in c.565 + 11921 A > G, c.565 + 6840 A > G, c.565 + 3453 C > T, and c.494 + 5808 C > T. These results provide useful information that the polymorphism of LTBP2 is significantly associated with TLN, body size, and carcass traits in Dezhou donkeys, which can serve as a molecule marker to improve donkey production performance.
Appraisal of coral bleaching thresholds and thermal projections for the northern Red Sea refugia

Corals in the northern Red Sea exhibit high thermal tolerance despite the increasing heat stress. It is assumed that corals throughout the Red Sea have similar bleaching thresholds (32°C or higher), and hence greater bleaching tolerance of corals in the northern Red Sea region is likely due to lower ambient water temperatures (25–28°C) that remain well below the corals’ physiological maxima. Whether bleaching patterns across the Red Sea are independent of the local maximum monthly mean of seawater temperature and aligned with an assumed 32°C threshold has yet to be determined. Here, we used remotely sensed surface sea temperature data spanning 1982–2020 to model spatial distributions of Degree Heat Weeks across the Red Sea in relation to assumed coral thermal threshold values of 30, 31, and 32°C. We also used the Coupled Model Intercomparison Project Phase 5 model outputs to predict warming trends in the Red Sea under different greenhouse gas representative concentration pathways (RCPs). We show that applying 32°C thresholds dramatically reduces effective Degree Heat Weeks in the north, but not in central or southern Red Sea regions, a finding that is consistent with historical bleaching observations throughout the Red Sea. Further, model predictions under the most extreme RCP8.5 scenario exhibited ~3°C warming by the end of the 21st century (1998-2020) throughout the Red Sea with less pronounced warming for the northern Red Sea (2–2.5°C) compared to the central and southern regions (2.7–3.1°C). This warming rate will remain below the assumed thermal threshold for the northern Red Sea which should help this region to serve as refugia (i.e., maintaining favorable temperatures) for corals to persist for decades ahead. Together, our results support the notion that corals have similar thresholds throughout the Red Sea; hence, coral bleaching thresholds are independent of the local maximum monthly mean. Consequently, where regional warming projections suggest the northern Red Sea will not reach assumed bleaching thresholds (32°C) before the end of the 21st century, coral reefs in the northern region may be among the last standing against climate change.