Miracle-dz/UniFAR-FTUs huggingface dataset:
Trend analysis and forecasting of publication activities by Indian computer science researchers during the period of 2010–23

Huge collections of published research documents are available in various repositories in Indian universities and research organizations. The efficient retrieval, estimation of research trends, and identification of research gaps with the global trend in different research areas, can be a great guiding tool for regulating research in the appropriate direction. This research attempts to analyse the trend of research activities carried out by Indian researchers in the discipline of Computer Science from 2010 to 19 and forecast the upcoming research trend for the years 2020–23. A repository of the abstracts based on domains given in the Computer Science Ontology (CSO) published by the Indian researchers is developed from the Scopus database. Document Index Graph document representation model is used to store the repository, shared phrases across the documents are extracted and phrase‐based similarity is computed. Combining the Single‐term and Phrase‐based similarity, the hybrid similarity is generated and similar documents are clustered using the DBSCAN clustering technique. Topics are identified for each cluster using the Latent Dirichlet Allocation algorithm and are automatically labelled using CSO. For each topic, the trend analysis and forecasting have been done using the Auto‐Regressive Integrated Moving Average. For the assessment of the forecasting performance, the dataset from 2010 to 17 is used as a training dataset and 2018–19 as a testing dataset. The average forecasting for the year 2018 for all CSO domains belongs to the Good forecasting category with Mean Absolute Percentage Error (MAPE) 18.34, and 2019 shows reasonable forecasting with MAPE 30.20 as per the MAPE interpretation given by Lewis. For each topic the average forecasting for years 2018–19 shows either Highly accurate, Good or Reasonable forecasting. As a result, the top four domains for the years 2020–23 are also identified which can help initial researchers in the identification of a relevant topic for research and exploration.
The Influence of Leadership, Workload and Work Environment on the Work Motivation of Employees of the Personnel Agency and Resource Development Human South Coast District

This study aims to determine the effect of leadership, workload and work environment on work motivation employees of Agency For Personnel and Human Resources Development Agency (BKPSDM) Pesisir Selatan Regency. The method used in this research is quantitative research with survey and descriptive approach. The population in this study were employees of Agency For Personnel and Human Resources Development Agency (BKPSDM) Pesisir Selatan Regency. The sample used was 48 people using saturated sampling technique. The data analysis technique is multiple linear regression. The results showed that: (1) Leadership has a positive and significant effect on work motivation employees, (2) Workload has a negative and significant effect on work motivation, (3) Work environment has a positive and significant effect on work motivation employees
Effect of the Longitudinal Tensile Creep on the Stiffness of Radiata Pine (Pinus radiata D. Don)

The influence of load on the cellulose microfibrils of single cells or thin wood foils is known. It can decrease the cellulose microfibril angles and, in turn, increase the stiffness. However, this modification of a piece of wood, which is made up of multiple cells, is unknown. The aim of this research was to study the effect of tensile creep on the longitudinal stiffness of radiata pine wood. The modulus of elasticity of each specimen was determined before and after being subjected to tensile creep. The samples were loaded at 1170 N and 1530 N for 20 min at 70 °C. The load was determined as a function of a percentage of the force at the proportional limit. The moduli of elasticity before and post-tensile creep showed no effect on the stiffness of wood at the macroscopic level, but neither were there damage to the cell structure. It can be assumed that there are changes at the microscopic level, but they are not enough to be reflected at the macro scale. It is also challenging to achieve the modifications that occur at the level of a single cell or in thin wood foils; however, the implications of this would be favorable for the development of stronger wood-based products.
LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis

TNF and LTα are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to the Ltb gene within the TNF/LT locus inside MHC. Unlike Ltb, transcription of Tnf and of Lta is tightly controlled, with the Tnf gene being an immediate early gene that is rapidly induced in response to various inflammatory stimuli. Genes of the TNF/LT locus play a crucial role in lymphoid tissue organogenesis, although some aspects of their specific contribution remain controversial. Here, we present new findings and discuss the distinct contribution of TNF produced by ILC3 cells to Peyer’s patch organogenesis.
Single-Step Fast Tissue Clearing of Thick Mouse Brain Tissue for Multi-Dimensional High-Resolution Imaging

Recent advances in optical clearing techniques have dramatically improved deep tissue imaging by reducing the obscuring effects of light scattering and absorption. However, these optical clearing methods require specialized equipment or a lengthy undertaking with complex protocols that can lead to sample volume changes and distortion. In addition, the imaging of cleared tissues has limitations, such as fluorescence bleaching, harmful and foul-smelling solutions, and the difficulty of handling samples in high-viscosity refractive index (RI) matching solutions. To address the various limitations of thick tissue imaging, we developed an Aqueous high refractive Index matching and tissue Clearing solution for Imaging (termed AICI) with a one-step tissue clearing protocol that was easily made at a reasonable price in our own laboratory without any equipment. AICI can rapidly clear a 1 mm thick brain slice within 90 min with simultaneous RI matching, low viscosity, and a high refractive index (RI = 1.466), allowing the imaging of the sample without additional processing. We compared AICI with commercially available RI matching solutions, including optical clear agents (OCAs), for tissue clearing. The viscosity of AICI is closer to that of water compared with other RI matching solutions, and there was a less than 2.3% expansion in the tissue linear morphology during 24 h exposure to AICI. Moreover, AICI remained fluid over 30 days of air exposure, and the EGFP fluorescence signal was only reduced to ~65% after 10 days. AICI showed a limited clearing of brain tissue >3 mm thick. However, fine neuronal structures, such as dendritic spines and axonal boutons, could still be imaged in thick brain slices treated with AICI. Therefore, AICI is useful not only for the three-dimensional (3D) high-resolution identification of neuronal structures, but also for the examination of multiple structural imaging by neuronal distribution, projection, and gene expression in deep brain tissue. AICI is applicable beyond the imaging of fluorescent antibodies and dyes, and can clear a variety of tissue types, making it broadly useful to researchers for optical imaging applications.
Effects of Maca on Muscle Hypertrophy in C2C12 Skeletal Muscle Cells

With aging, sarcopenia and the associated locomotor disorders, have become serious problems. The roots of maca contain active ingredients (triterpenes) that have a preventive effect on sarcopenia. However, the effect of maca on muscle hypertrophy has not yet been investigated. The aim of this study was to examine the effects and mechanism of maca on muscle hypertrophy by adding different concentrations of yellow maca (0.1 mg/mL and 0.2 mg/mL) to C2C12 skeletal muscle cell culture. Two days after differentiation, maca was added for two days of incubation. The muscle diameter, area, differentiation index, and multinucleation, were assessed by immunostaining, and the expression levels of the proteins related to muscle protein synthesis/degradation were examined by Western blotting. Compared with the control group, the muscle diameter and area of the myotubes in the maca groups were significantly increased, and the cell differentiation index and multinucleation were significantly higher in the maca groups. Phosphorylation of Akt and mTOR was elevated in the maca groups. Maca also promoted the phosphorylation of AMPK. These results suggest that maca may promote muscle hypertrophy, differentiation, and maturation, potentially via the muscle hypertrophic signaling pathways such as Akt and mTOR, while exploring other pathways are needed.
Elevated Alpha 1(I) to Alpha 2(I) Collagen Ratio in Dermal Fibroblasts Possibly Contributes to Fibrosis in Systemic Sclerosis

Systemic sclerosis (SSc) is characterized by excessive collagen deposition in the skin and internal organs. Activated fibroblasts are the key effector cells for the overproduction of type I collagen, which comprises the α1(I) and α2(I) chains encoded by COL1A1 and COL1A2, respectively. In this study, we examined the expression patterns of α1(I) and α2(I) collagen in SSc fibroblasts, as well as their co-regulation with each other. The relative expression ratio of COL1A1 to COL1A2 in SSc fibroblasts was significantly higher than that in control fibroblasts. The same result was observed for type I collagen protein levels, indicating that α2(I) collagen is more elevated than α2(I) collagen. Inhibition or overexpression of α1(I) collagen in control fibroblasts affected the α2(I) collagen levels, suggesting that α1(I) collagen might act as an upstream regulator of α2(I) collagen. The local injection of COL1A1 small interfering RNA in a bleomycin-induced SSc mouse model was found to attenuate skin fibrosis. Overall, our data indicate that α2(I) collagen is a potent regulator of type I collagen in SSc; further investigations of the overall regulatory mechanisms of type I collagen may help understand the aberrant collagen metabolism in SSc.
Impact of marketing communication and information sharing on the productivity of India's small and medium-sized businesses (SMEs)

The purpose of this research is to investigate the influence that marketing communication and information sharing have on the performance of businesses. The relationship between marketing communication, information sharing, client retention, and personalization, as well as the success of the firm, is investigated in this approach. In this research endeavour, a questionnaire was the instrument of choice for data collecting. A questionnaire was constructed with the help of previously discovered scale items relevant to marketing communication, information sharing, customer retention, personalization, and business performance. This led to the development of the questionnaire. The staff members of India's small and medium-sized firms (SMEs) each received one of the 500 questionnaires that were handed out to them. Partial Least Square was the statistical tool that was used to do the analysis of the data (PLS). It has been discovered that effective marketing communication has a beneficial effect on the retention of existing customers, which in turn leads to improved company performance. Additionally, the exchange of information has a beneficial effect on customisation, which ultimately leads to the performance of the company.
Cytotoxicity, Epidermal Barrier Function and Cytokine Evaluation after Antiseptic Treatment in Bioengineered Autologous Skin Substitute

Bioengineered autologous skin substitutes (BASS) technology is an emerging field for skin burn therapy. However, further studies on BASS characterization, viability against standard procedures for wound healing, and protocol optimization are necessary for the improvement of BASS technology for clinical use. The aim of this study is to evaluate the effect of common antiseptics for clinical use in BASS, focusing on cell viability, inflammatory cytokine pattern, and epithelium and skin barrier integrity, in order to establish the most adequate treatment for wound care after BASS grafting. Human keratinocytes (hKT) and dermal fibroblasts (hDF) were isolated from foreskin samples and integrated into hyaluronic acid-based BASS. The following antiseptics were applied every 48 h: ethanol (70%), chlorhexidine digluconate (1%), sodium hypochlorite (0.02%), povidone iodine (100 mg/mL), and polyhexanide (0.1%), during a follow-up of 16 days. Sodium hypochlorite was the only treatment that showed a high cell viability percentage throughout the evaluation time compared to other antiseptic treatments, as well as a similar cytokine secretion pattern as control BASS. No significant differences were found regarding epidermal barrier function. These findings point towards sodium hypochlorite being the least aggressive antiseptic treatment for BASS post-transplantation wound care.
Computer Vision-Based Hazard Identification of Construction Site Using Visual Relationship Detection and Ontology

Onsite systematic monitoring benefits hazard prevention immensely. Hazard identification is usually limited due to the semantic gap. Previous studies that integrate computer vision and ontology can address the semantic gap and detect the onsite hazards. However, extracting and encoding regulatory documents in a computer-processable format often requires manual work which is costly and time-consuming. A novel and universally applicable framework is proposed that integrates computer vision, ontology, and natural language processing to improve systematic safety management, capable of hazard prevention and elimination. Visual relationship detection based on computer vision is used to detect and predict multiple interactions between objects in images, whose relationships are then coded in a three-tuple format because it has abundant expressiveness and is computer-accessible. Subsequently, the concepts of construction safety ontology are presented to address the semantic gap. The results are subsequently recorded into the SWI Prolog, a commonly used tool to run Prolog (programming of logic), as facts and compared with triplet rules extracted from using natural language processing to indicate the potential risks in the ongoing work. The high-performance results of Recall@100 demonstrated that the chosen method can precisely predict the interactions between objects and help to improve onsite hazard identification.
A Novel Crossbeam Structure with Graphene Sensing Element for N/MEMS Mechanical Sensors

A graphene membrane acts as a highly sensitive element in a nano/micro–electro–mechanical system (N/MEMS) due to its unique physical and chemical properties. Here, a novel crossbeam structure with a graphene varistor protected by Si3N4 is presented for N/MEMS mechanical sensors. It substantially overcomes the poor reliability of previous sensors with suspended graphene and exhibits excellent mechanoelectrical coupling performance, as graphene is placed on the root of the crossbeam. By performing basic mechanical electrical measurements, a preferable gauge factor of ~1.35 is obtained. The sensitivity of the graphene pressure sensor based on the crossbeam structure chip is 33.13 mV/V/MPa in a wide range of 0~20 MPa. Other static specifications, including hysteresis error, nonlinear error, and repeatability error, are 2.0119%, 3.3622%, and 4.0271%, respectively. We conclude that a crossbeam structure with a graphene sensing element can be an application for the N/MEMS mechanical sensor.
Extraction and Evaluation of Bioactive Compounds from Date (Phoenix dactylifera) Seed Using Supercritical and Subcritical CO2 Techniques

Date (Phoenix dactylifera) seed is a potential source of natural antioxidants, and the use of innovative green and low temperature antioxidant recovery techniques (using CO2 as solvent) such as supercritical fluid (SFE) and subcritical (SubCO2) extractions can improve their yields and quality in the extracts. SFE, SubCO2 and Soxhlet techniques were employed to enrich antioxidants in extracts from Sukari (SKSE), Ambara (AMSE), Majdool (MJSE) and Sagai (SGSE) date seeds. Extract yields were evaluated and modelled for SFE extract using response surface methodology. Significantly higher (p < 0.05) phenolics (143.48–274.98 mg GAE/100 g), flavonoids (78.35–141.78 mg QE/100 g), anthocyanins (0.39–1.00 mg/100 g), and carotenoid (1.42–1.91 mg BCE/100 g) contents were detected in extracts obtained using SFE and SubCO2 methods. The evaluation of in vitro antioxidant properties showed that SFE and SubCO2 seed extracts demonstrated promising antioxidant (13.42–23.83 µg AAE/mL), antiradical (228.76–109.69 µg/mL DPPH IC50), ferric reducing antioxidant power (1.43–2.10 mmol TE/100 g) and ABTS cation scavenging (375.74-717.45 µmol TE/100 g) properties that were significantly higher than Soxhlet extracts. Both SFE and SubCO2 techniques can be effectively utilized as innovative and environmentally friendly alternatives to obtain high quality antioxidant rich extracts from date seed. These extracts may have potential functional and nutraceutical applications.
Effects of Oral Health Interventions in People with Oropharyngeal Dysphagia: A Systematic Review

People with oropharyngeal dysphagia (OD) are at risk of developing aspiration pneumonia. However, there is no “best practice” for oral health interventions to improve swallowing-related outcomes, the incidence of aspiration pneumonia, and oral health in people with OD. Systematic literature searches were conducted for oral health interventions in OD in PubMed, Embase, CINAHL, and PsycINFO until July 2021. Original articles published in English and reporting pre- and post-intervention measurements were included. The methodology and reporting were guided by the PRISMA checklist. The methodological quality of the eight included studies was rated using the QualSyst critical appraisal tool. The oral health interventions in people with OD were diverse. This study shows little evidence that regular oral care and the free water protocol or oral disinfection reduced the incidence of aspiration pneumonia in people with OD. Oral cleaning, twice a day with an antibacterial toothpaste in combination with intraoral cleaning or the free water protocol, proved to be the most promising intervention to improve oral health. The effect of improved oral health status on swallowing-related outcomes could not be established. Increasing awareness of the importance of oral health and implementing practical oral care guidelines for people involved in the daily care of people with OD are recommended.
The Pointing Behavior of Deaf and Hearing Mothers in the Course of Their Infants' Signed/Spoken Language Acquisition

Abstract:This longitudinal pilot study examined the pointing behavior of two Israeli Deaf mothers and one hearing mother over the course of their infant's signed/spoken language acquisition. Three aspects were analyzed: (a) frequency of use; (b) function; and (c) pointing form. The findings indicated that the Deaf mothers used pointing more frequently than the hearing mother, but pointing was produced by all mothers to denote present referents and locations and to complement messages conveyed in speech/signing. All three mothers consistently used hand and handshape pointing, though only the Deaf mothers used the Israeli Sign Language (ISL) handshape for possessives. The duration of the Deaf mothers' pointing varied during the study period. The findings suggest that pointing gradually becomes sign-like units used by the Deaf mothers and changes according to their infants' growing communicative abilities. In contrast, the form of the hearing caregiver's pointing remains steady, as well as the reinforcement-complementary role it plays alongside speech. The results illustrate the significance of parental modifications in the course of their infants' signed/spoken language acquisition as a model that can help children learn new forms, functions, and structures.
Derangements and Reversibility of Energy Metabolism in Failing Hearts Resulting from Volume Overload: Transcriptomics and Metabolomics Analyses

Derangements in cardiac energy metabolism have been shown to contribute to the development of heart failure (HF). This study combined transcriptomics and metabolomics analyses to characterize the changes and reversibility of cardiac energetics in a rat model of cardiac volume overload (VO) with the creation and subsequent closure of aortocaval fistula. Male Sprague–Dawley rats subjected to an aortocaval fistula surgery for 8 and 16 weeks exhibited characteristics of compensated hypertrophy (CH) and HF, respectively, in echocardiographic and hemodynamic studies. Glycolysis was downregulated and directed to the hexosamine biosynthetic pathway (HBP) and O-linked-N-acetylglucosaminylation in the CH phase and was further suppressed during progression to HF. Derangements in fatty acid oxidation were not prominent until the development of HF, as indicated by the accumulation of acylcarnitines. The gene expression and intermediates of the tricarboxylic acid cycle were not significantly altered in this model. Correction of VO largely reversed the differential expression of genes involved in glycolysis, HBP, and fatty acid oxidation in CH but not in HF. Delayed correction of VO in HF resulted in incomplete recovery of defective glycolysis and fatty acid oxidation. These findings may provide insight into the development of innovative strategies to prevent or reverse metabolic derangements in VO-induced HF.
Autogenous Dentin Particulate Graft for Alveolar Ridge Augmentation with and without Use of Collagen Membrane: Preliminary Histological Analysis on Humans

(1) Background: The phenomenon of ankylosis of the dental elements has led clinicians to think that properly treated dentin and cement may be a potential graft for alveolar ridge augmentation. Currently, there are no studies in the literature able to histomorphometrically compare the healing patterns of an autogenous dentin particulate graft with the association, or not, of resorbable membranes. The aim of this pilot study is to histologically compare bone after an alveolar ridge augmentation using an autogenous dentin particulate graft with and without a resorbable collagen membrane. (2) Methods: this clinical trial enrolled six patients with defects requiring bone augmentation. Two procedures were performed in all six adult human patients in order to perform a study–control study: in Group 1, a ridge augmentation procedure with an autogenous dentin particulate graft and a resorbable collagen membrane was performed, and, in Group 2, an alveolar ridge preservation without a membrane was performed at the same time (T0). At 4 months, a biopsy of the bone tissues was performed using a 4 mm trephine bur in order to perform a histomorphometric analysis. (3) Results: The histomorphometric analysis demonstrated that Group 1 presented 45% of bone volume, 38% of vital bone, and 7% of residual graft. On the contrary, membrane-free regenerative procedures demonstrated 37% of bone volume, 9% of vital bone, and 27% of non-resorbed graft. In all cases, the regenerated bone allowed the insertion of implants with a standard platform, and no early failures were recorded. (4) Conclusions: Autogenous dentin particulate grafts seem to work best when paired with a membrane.