Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypermutagenic induction of mitotic recombination by ionizing radiation in Mlhl null mouse cells

approved: Mitchell S. Turker Mitotic recombination is a common autosomal mutation in mammalian cells involving crossover events between homologous chromosomes. This process can convert a cell with a heterozygous deficiency to one with a homozygous deficiency, and thus often represents the second step in tumor suppressor gene inactivation. In this study I examined the frequency and spectrum of ionizing radiation (IR)-induced autosomal mutations affecting Aprt activity in a mouse kidney cell line null for the Mihi mismatch repair (MMR) gene. The mutant frequency results demonstrated a hypermutable response to JR and the spectral analysis revealed that most of this response was due to the induction of mitotic recombinational events. High frequency induction of mitotic recombination was not observed in a DNA repair-proficient cell line or a cell line with an MMRindependent mutator type. I also provide evidence that JR exposure did not induce significant numbers of base-substitution in the Mihi null cells. These results demonstrate that IR exposure can initiate a process leading to mitotic recombinational events and that MMR function suppresses these events. My Redacted for privacy results suggest a caveat for use of IR to treat MMR deficient tumors because the combination of high levels of induced mitotic recombinational events and preexisting intragenic mutations might increase malignant potential in surviving
Parámetros genéticos de la fertilidad en dos líneas de conejo de diferente aptitud

En producción de carne de conejo, la eficacia de la producción y el rendimiento económico de las explotaciones depende en gran parte del éxito reproductivo, el cual está condicionado a la fertilidad y al tamaño de camada. La fertilidad puede ser considerada un carácter de la hembra, del macho o de ambos. Depende de un gran número de factores ambientales y genéticos. En otras especies, diversos autores han mostrado que existe poca, casi nula, variación genética en la fertilidad (en vacuno: JANSEN, 1986; SÉLLER and RON, 1992; BOICHARD y MANFREDI, 1994; WEIGEL y REKAYA, 2000; en porcino: VARONA y NOGUERA, 200 l) pero en conejo, Ja información publicada en la literatura acerca de los componentes de varianza de este carácter es muy limitada. Únicamente existen tres trabajos referentes a la repetibilidad (BLASCO et al., 1979) y heredabilidad (KHALIL and SOLIMAN, 1989; MouRA et al., 2001) de la fertilidad de la hembra medida como número de presentaciones al macho y ninguno en relación con la fert ilidad del macho. Hasta el momento, los esfuerzos de Ja selección se han centrado en el tamaño de camada y únicamente se practica una selección de baja intensidad con respecto a este carácter eliminando individuos estériles.
Radioisotope Thermophotovoltaic Generator Design and Performance Estimates for Terrestrial Applications

This work provides the design methods and performance estimates of the radioisotope thermophotovoltaic system (RTPV) for terrestrial applications. The modeling is based on an experimentally tested prototype using two-dimensional high temperature photonic crystal to realize spectral control. The design efforts focus on the optimization of the system efﬁciency and con-tain the heat source number, the size of the energy conversion elements, the insulation conﬁguration, and the heat sink design. An equivalent circuit model was developed for the thermal and electrical performances. Based on a speciﬁc output requirement, an optimized heat source number and energy conversion area can be computed for a certain cell type and insulation design. The selection and characterization of the low bandgap thermophotovoltaic (TPV) cells applicable to the generator are compared and discussed. The generator’s heat sink design uses extended ﬁns and the performance is estimated based on the external operating conditions. Finally, the work provides a design example of a terrestrial RTPV generator with an output level of ∼ 40 W electrical power (W e ) using InGaAsSb cell, reaching an efﬁciency of 8.26%.
Modeling a Nonlinear Binary Distillation Column

Because the process dynamics tend to become too complex to be efficiently controlled, there is always a need to develop innovative control technologies, in order to obtain high economic performance. A way to achieve this objective is to use one of the control strategies which rely on the controlled process model such adaptive control, model predictive control, internal model control, robust control. In order to use one of these control techniques, the process model has to be obtained. The purpose of this paper is to present a model identification method, based on Markov parameters, for a nonlinear chemical process, the propylene/propane binary distillation column.
Pollution dispersion from highways: Enhancing particulate matter capture using aerodynamics

People living or working close to the highways are at risk to higher exposure levels of different air pollutants, one of which is particulate matter. The Antea group has recently proposed the addition of Electrostatic Precipitators (or ESPs) on the top of sound barriers adjacent to highways, in order to capture the particulate matter and safely discard them. This is an attractive, but expensive, supplement. While estimates of the collection efficiency (i.e. what percentage of particulate matter mass entering the ESP is collected by the device) are known, the aerodynamic efficiency of the ESP (i.e. what percentage of pollutants reach the ESP entrance as compared to the mass emitted) is yet to be determined. The net efficiency of the ESP will be the product of the above two efficiencies, making it necessary to study the latter, prior to large-scale installation. Scaled down experiments were performed in a water channel, housed in the Laboratory for Aero and Hydrodynamics at the Delft University of technology. Simultaneous measurements of the flow velocities and dye intensities in the symmetry-plane of the channel were made through planar Particle Image Velocimetry (PIV) and Planar Laser Induced Fluorescence (PLIF). A few flow configurations were studied by varying certain parameters. It was found that: (a) ESP installation is more beneficial on top of shorter sound barriers. (b) Slightly raising the ESP from the top of the sound barrier is advantageous. (c) Installation of ESPs in isolated highway canyons should be done with care, as several flow regimes are observed. First order estimates on the aerodynamic efficiencies of the ESP were determined. This was accompanied by the identification of ESP performance trends that should serve as a guideline for the initial testing of the ESPs at full scale. The guidelines include the physical location and entrance orientation of the ESP. It is known that the collection efficiency of the ESP is a function of the incoming flow velocity. It is recommended that the entrance flow velocities reported here be used as an input for calculating the associated particle collection efficiency. Together, the collection and aerodynamic efficiencies can be used to estimate the overall efficiency of the ESP. If the overall efficiency satisfies a minimum desirable threshold, the field experiments yield promising results, the device clears safety requirements, and the benefits outweigh the costs, the ‘Open Air Line ESP’ can be installed along the highways en masse in the future.
Miniaturized circular array [for intravascular ultrasound]

Intravascular ultrasound demands miniature transducers that can be guided through tiny blood vessels. Other applications in medicine and industry can also benefit from a highly miniaturized catheter based transducer design. The smaller the geometry the more useful and versatile the resulting device will be. Design consideration of geometry versus performance tradeoffs, other acoustic properties in array design and the methods of synthetic aperture beamforming are well known. Therefore, we have focused our paper on the details and intricacies of manufacturing extremely small ultrasound arrays.
WETD /spl minus/ a finite element time-domain approach for solving Maxwell's equations

A family of finite element time-domain methods, WETD(/spl Theta/), is derived to solve the time-varying Maxwell's equations. The proposed methodology is based upon the application of the Faedo-Galerkin procedure and the use of the Whitney 1-forms as bases to result in an ordinary differential equation in time for the electric field. Moreover, the resultant ordinary differential equation is solved by employing central and/or backward difference approximations. Since the WETD methods presented here are used in conjunction with tetrahedral finite element meshes, it imposes no limitations on the problem geometry. Also, in this contribution, a general stability condition has been derived for the WETD(/spl Theta/) method of which the central and backward differences are special cases corresponding to /spl Theta/=1 and /spl Theta/=0, respectively. >
Electrokinetic and Electrochemical Methods for Microbial and Organic Fouling Mitigation at Liquid-Solid Interfaces

Organic and microbial fouling are the initial steps for biofilm formation, resulting in severe fouling problems in many environmental and engineered applications including membrane water filtration. Electro-active methods are proposed to mitigate microbial as well as organic fouling via electrokinetic and/or electrochemical mechanisms. In the first part of this thesis, a parallelelectrode configuration was adopted and the cathode antifouling was evaluated. A carbon nanotube-polyvinylidene fluoride (CNT-PVDF) porous non-Faradaic cathode was first fabricated on top of an ultrafiltration (UF) membrane to produce negative surface charges via capacitive charging at 2 V, which reduced energy requirements (up to 2-fold) in comparison to the unmodified control. A semi-quantitative study was then completed on cathode coatings of different nanomaterials (CNM) to reduce microbial fouling. The bacterial attachment and inactivation were correlated to the electric potential and cathodic H2O2 generation, respectively. Next, a CNT and carbon black (CB) composite cathode was made on a forward osmosis (FO) membrane surface and challenged with synthetic and actual wastewater, which reduced fouling in regard to initial flux loss (~60%) for the actual wastewater and fouling rate (~50%) for both solutions at 2 V in 84 h. In the other part of the thesis, the electrode configuration was improved by fabricating interlaced surface electrodes on a substrate or membrane surface instead of only using a cathode. Insulated interlaced Ag electrodes resulted in optimal bacterial inactivation (84%) and detachment (94% after 15 h biofilm growth) with 2 min treatment at 50 V AC (10 kHz). Interlaced CNT electrodes
Numerical simulation of the hydrodynamic behaviour of mussel farm in currents

ABSTRACT A numerical model of mussel farm in current was developed to analyse its hydrodynamic performance, in which the mussel dropper was simulated as a porous media. The Reynolds-Average Naiver–Stokes (RANS) equation was applied to simulate the flow around the mussel farm, and the Darcy–Forchheimer equation was adopted to consider the effect of the porous media. A slew of physical model tests were used to validate the numerical model. The results indicate that our numerical model is appropriate to investigate the hydrodynamic behaviour of the mussel droppers in current. The hydrodynamic performance of mussel farms in different water depths was numerically investigated. In addition, the influence of the mussel dropper density and the oblique current was analysed comprehensively. The results indicate that the shielding effect of mussel droppers is increased with the increasing water depth.
An empirical investigation of demographic and work environment factors affecting the recruitment and retention of accounting professionals

Recruitment and staff retention have become a substantial problem in the Australian professional accountancy environment. Although this issue has been canvassed in the professional literature, little academic research has been conducted into the area. By contrast, staffing problems have been a fertile field for research in foreign countries, especially the US. This thesis presents the results of a survey of practitioners employed by the 20 largest public accountancy firms in Eastern Australia. The method of the survey, ' is broadly similar to that used by some US researchers. These authors have cross-correlated the demographic characteristics of respondents, with their responses to attitudinal questions regarding an array of factors which affect their propensity to enter, and stay within, the profession. Such factors include salary remuneration, working conditions, job satisfaction and working pressure. Hypotheses development is based on contentious issues contemporary to the professional environment, and is divided functionally into the demographic areas of educational background, gender, country of origin, and size of firm. The results provide substantive evidence on a wide field of issues, including: the ability and motivation of university compared with non-university graduates, barriers to female accountants, and the merits and demerits of working in a larger or smaller accountancy firm.
First-Principles Calculation of Principal Hugoniot and K-Shell X-ray Absorption Spectra for Warm Dense KCl

Principal Hugoniot and K-shell X-ray absorption spectra of warm dense KCl are calculated using the first-principles molecular dynamics method. Evolution of electronic structures as well as the influence of the approximate description of ionization on pressure (caused by the underestimation of the energy gap between conduction bands and valence bands) in the first-principles method are illustrated by the calculation. Pressure ionization and thermal smearing are shown as the major factors to prevent the deviation of pressure from global accumulation along the Hugoniot. In addition, cancellation between electronic kinetic pressure and virial pressure further reduces the deviation. The calculation of X-ray absorption spectra shows that the band gap of KCl persists after the pressure ionization of the $3p$ electrons of Cl and K taking place at lower energy, which provides a detailed understanding to the evolution of electronic structures of warm dense matter.
维奈克拉治疗恶性血液病异基因造血干细胞移植后复发25例疗效及安全性

目的 观察维奈克拉（VEN）治疗异基因造血干细胞移植（allo-HSCT）后复发恶性血液病患者的疗效及安全性。 方法 回顾性分析2021年2月至2021年11月在中国医学科学院血液病医院接受VEN治疗的25例allo-HSCT后复发患者的临床资料，其中微小残留病（MRD）阳性患者15例（抢先治疗组），形态学复发患者10例（挽救治疗组）。 两组VEN剂量均为400 mg/d，联合唑类抗真菌药物时减量至100 mg/d。 结果 ①抢先治疗组男7例，女8例，中位年龄32（18～52）岁；急性髓系白血病（AML）13例，急性淋巴细胞白血病（ALL）1例，原发性骨髓纤维化（PMF）1例；MRD阳性至应用VEN中位时间为2. 5（0～12.5）个月。 VEN中位疗程数为2（1～4）个。 第1疗程治疗第7天VEN中位血药浓度为1 945（688～5 383）µg/L。 VEN治疗1疗程后8例患者MRD转为阴性（获得主要反应），4例MRD较治疗前下降50％，3例无效，总体反应率（ORR）为80％（12/15）。 9例治疗第7天VEN血药浓度<1 000 µg/L或>3 000 µg/L患者中3例（33.3％）MRD转阴，6例VEN血药浓度1 000～3 000 µg/L患者中5例（83.3％）MRD转阴。 5例患者出现3/4级中性粒细胞减少，5例患者出现3/4级血小板减少，无新发严重感染致死病例。 ②挽救治疗组男7例，女3例，中位年龄44（28～59）岁；AML 6例，ALL 2例，不典型慢性髓性白血病（aCML）1例，骨髓增生异常综合征难治性血细胞减少伴有多系发育异常（MDS-RCMD）1例；复发至应用VEN中位时间为0（0～1）个月；VEN中位疗程数为1（1～2）个；第1疗程治疗第7天VEN中位血药浓度为2 419（1 200～6 155）µg/L。 VEN治疗1疗程后3例获得完全缓解（CR）（主要反应），3例获得部分缓解（PR），4例无效，ORR为60％（6/10）。 4例治疗第7天VEN血药浓度>3 000 µg/L患者中1例获得CR，6例VEN血药浓度1 000～3 000 µg/L患者中2例获得CR。 10例患者均出现3/4级中性粒细胞减少及3/4级血小板减少。 1例患者因严重肺感染死亡。 ③中位随访4. 5（1～8.5）个月，抢先治疗组、挽救治疗组总生存（OS）率分别为（70.2±12.7）％、（50.0±15.8）％（χ2＝1.873，P＝0.171）。 1疗程VEN治疗获得主要反应、未获得主要反应患者的OS率分别为（90.9±8.7）％、（36.2±14.7）％（χ2＝6.843，P＝0.009）。 3例存在TP53突变的患者在VEN治疗后均获得主要反应。 结论 应用VEN对allo-HSCT后复发的恶性血液病患者进行抢先/挽救治疗有一定疗效且耐受性良好，监测VEN血药浓度有望提高疗效。 VEN抢先/挽救治疗1个疗程未获得主要反应的患者预后较差，需尽早转换其他治疗方案。
Методы и алгоритмы оперативного решения задач оценивания показателей возможностей и устойчивости функционирования информационной системы

Now the important problems of structure dynamic control (SDC) theory are the evaluation and estimation of stability, goal, and informational-technological abilities for modern information system (IS). Our investigation shows that this problem can be solved by attainability set construction of SDC models. Preliminary evaluation of attainability sets for the SDC models lets allows to reduce the time (needed) required for solution of IS SDC tasks. Therefore in practice the different approximation of attainability sets are used. Methods and algorithms of evaluation of attainability sets for the SDC models are proposed.
MCDM-ECP: Multi Criteria Decision Making Method for Emergency Communication Protocol in Disaster Area Wireless Network

Disaster Area Wireless Networks (DAWNs) are widely deployed in natural or man-made disaster scenes, since the communication infrastructure may be completely destroyed by the disaster. This paper proposes a hybrid network architecture for DAWNs due to the mobility of first responders and refugees. Based on the link characterization of DAWNs, we choose four essential criteria and propose a multi-criteria decision-making method for emergency communication protocol (MCDM-ECP), which utilizes the analytic hierarchy process (AHP) method and Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS) method to find the optimal next-hop node in DAWNs. Routing discovery and routing maintenance processes are included in the novel protocol. The simulation results show that MCDM-ECP performs better than other classical protocols both in energy consumption and packet received rate (PRR) for long-term emergency communications.
Compact ammonia sources toward the G 10.5+0.00 HII region complex.

We present observations of the (2, 2) and (3, 3) inversion transitions of ammonia toward a group of compact H II regions near l=10°. 5, b=0°. 0, made at 4″ resolution using the VLA. We detected three distinct ammonia sources in a region of ∼2' in diameter. The densest and hottest cloud, having a line center velocity of 66.9±0.2 km s −1 , is associated with the G 10.47+0.03 cluster of ultracompact H II regions. It exhibits a core-halo structure; with a core of ∼0.08 pc in size surrounded by an envelope of ∼0.25 pc in diameter. The peak optical depth in the main line of the (2, 2) and (3, 3) transitions are 25 and 37, respectively
Apoptotic RBM38, TUSC2 and ANO1 Proteins ใน Human Serum Proteome มีความสัมพันธ์กับภาวะ

Hyperhomocysteinemia (HHcy ) is known as an independent risk factor for cardiovascular diseases. It can induce apoptosis of vascular smooth muscle cells. Currently, proteomic has been widely applied in scientific and clinical researches. This research is a preliminary study that used proteomic technique for comparative protein expressions with focusing on the molecular basis of CVD in HHcy condition. The aim of this study was to identify protein profiles between control (non-HHcy) group and three groups of HHcy. Chemiluminescense immunoassay was used for determination of plasma homocysteine levels. Protein expressions in human serum were determined and analyzed by gel electrophoresis and LC/MS-MS technique. Proteins were quantified by using DeCyderMS analysis software. Jvenn was used for comparing protein lists with venn diagram. Function and class of protein were demonstrated by using PANTHER software. The interaction of chemical and protein was predicted by using STITCH V.5. 0. Eight unique proteins were upregulated in hyperhomocysteinemia groups, including MUC-19, LPAR1, MAPO2, GPALPP1, FECH, TUSC2, RBM38 and ANO1. Notably, RBM38, TUSC2, and ANO1 found in subjects with plasma homocysteine levels more than 50 µmol/L were discovered and linked to CVD risks via apoptotic signaling pathways. This study provided better insight into the interaction between expressed proteins profiles after post-translational modification which may resulted in induction of physiological alteration that may related to homocysteine-induced CVD. BRCA1, breast cancer; KAT2B, K ( lysine ) acetyltransferase 2B; SIRT1, sirtuin 1; Haem, heme b; TP53, tumor protein p53, CDKN2A, cyclin-dependent kinase inhibitor 2A; ATM, ataxia telangiectasia mutated). **, *** represented unique proteins from case group II and case group III, respectively.
RELATIONSHIP BETWEEN MULTI-DIMENSIONAL RESOURCES AND FINANCIAL PERFORMANCE OF MUMIAS SUGAR COMPANY, KENYA

: Multidimensional resources consist of more than one feature/design which is considered complex or needs to be assessed from several points of view. It therefore encourages the management focus on value creation performance improvement of the organizations. Traditionally, governments have a number of times come to the aid of various organizations when they seem to hit the rock bottom. This however does not seem to be the solution to such organizations since most of them keep on nose-diving as much as the intervention is in place. Although much has been written on the various multidimensional resources, comparatively little is known about its effect on the financial performance of the sugar producing firms. It is therefore in this line that this study intended to establish whether multi-dimensional resources, affect the financial performance of the sugar producing firms and more so Mumias Sugar Company. The study was guided by the Resource-Dependence theory (RDT). The study adopted a mixed research design and targeted employees working in Mumias Sugar Company and farmers (former members of defunct Mumias Out growers Company (MOCO) in Mumias town. This included the Chief Executive Officer, the managing director, the departmental managers, the supervisors and the representatives of MOCO a total of 236 respondents. A sample of the study population was done. Questionnaires and were used as data collection instruments. To determine the validity of the questionnaire items, research experts were used to examine them, and their suggestions and comments used as a basis to modify the research items. Cronbach alpha coefficient was used as a reliability test. A value of above 0.7 confirmed the reliability of the research Sugar Company. The study recommend that the government before putting any direct injections in terms of finances to the sugar companies need to do a cost benefit analysis but more so an in-depth research on how such finance would be put to valuable use. The government should also review on the management of the Mumias Sugar Company and consider privatization of the sugar milling companies the stakeholders and more so the farmers do not feel that it is the right solution to the sugar crisis in the sugar belt areas.
Entropy, Gravity and the Mass-Boom

Verlinde presents the gravitational force as due to gradients of entropy, an emergent force, with far reaching consequences. Using the Hawking-Bekenstein entropy formulation, we arrive at the conclusion that the Mass-Boom effect, presented elsewhere, forces the entropy of the universe to increase. Then the Mass-Boom is directly related to the existence of gravity. The principle of Mach implies that the Mass-Boom is responsible for the expansion of the universe. Thus, the Mass-Boom effect is a necessary condition for: 1) the increase of entropy with time, 2) the existence of gravity, and 3) for the expansion of the universe. The universe seems to initially appear and grow out of polarization: positive mass-boom (energy) versus negative gravitational potential energy boom, adding both always to zero. Polarization is then the cause of creation and evolution of the universe.