Miracle-dz/UniFAR-FTUs huggingface dataset:
Becker Digital

Objective . To test the hypothesis that maternal obesity is an independent risk factor for rectovaginal group B streptococcus (GBS) colonization at term. Study Design . Retrospective cohort study of consecutive women with singleton term pregnancies admitted in labor at Barnes-Jewish Hospital (2004–2008). Maternal BMI ≥ 30 Kg/m 2 (obese) or < 30 Kg/m 2 (nonobese) defined the two comparison groups. The outcome of interest was GBS colonization from a positive culture. Baseline characteristics were compared using Student’s t -test and Chi-squared or Fisher’s exact test. The association between obesity and GBS colonization was assessed using univariable and multivariable analyses. Results . Of the 10,564 women eligible, 7,711 met inclusion criteria. The prevalence of GBS colonization in the entire cohort was relatively high (25.8%). Obese gravidas were significantly more likely to be colonized by GBS when compared with nonobese gravidas (28.4% versus 22.2%, 𝑃 < 0.001 ). Obese gravidas were still 35% more likely than nonobese women to test positive for GBS after adjusting for race, parity, smoking, and diabetes (adjusted OR 1.35 [95% CI 1.21– 1.50]). Conclusion . Maternal obesity is a significant risk factor for GBS colonization at term. Further research is needed to evaluate the impact of this finding on risk-based management strategies.
Digital Commons @ University of Digital Commons @ University of South Florida South Florida

The growing public health burden associated with insufficient physical activity has resulted in the development of numerous health initiatives and products aimed at stabilizing and reversing the negative trends reported in epidemiological literature. A relatively novel product that has only recently made its way to the market are wearable weights. These products are designed to be worn on the lower legs and arms along with regular clothing as a means to increase caloric expenditure. However, no research to date has tested the efficacy of this product. PURPOSE: Compare psychological responses within bouts of aerobic exercise that vary on intensity and the presence of wearable weights. METHODS: Seventeen (11 female, 6 male, mean age = 24 years, mean BMI = 25.0 ) healthy volunteers were tested for aerobic fitness on a treadmill to determine VO2 max (mean = 44 ml x kg-1 x min-1). Participants then completed eight 30-minute walking trials on a treadmill while three ratings of perceived exertion (RPE – overall, RPE - chest and breathing, and RPE - legs ) were monitored while walking at different speeds and with varying combination of upper and lower body wearable weights. The design included two intensities (slow walking and brisk walking) and four conditions (no weights, arm weights, leg weights, and arm and leg weights) for a total of eight experimental trials. RESULTS: Data were analyzed using ANOVA and pairwise
Analysis of Sales Promotion, Perceived Ease of Use and Security on Consumer Decisions to Use DANA Digital Wallet

:- This study intends to analyze the effect of sales promotion, perceived ease of use, and security on consumer decisions to use the DANA digital wallet in DKI Jakarta. The sampling method was using accidental sampling. This research was conducted using a questionnaire method, conducted on 100 respondents. Quantitative analysis includes validity and reliability tests, classical assumption test, coefficient of determination R2, F test, t test and multiple regression analysis. The R2 value of 0.617 shows that 61.7% of the decision to use reached is indeed influenced by independent variables (sales promotion, perceived ease of use, and perception of security). Test the value of F 0,000; which shows sales promotion, perceived ease of use, and perceived security as independent variables simultaneously influence consumer decisions.
Special Section on Transporters in Drug Disposition and Pharmacokinetic Prediction Physiologically Based Pharmacokinetic Modeling of Bosentan Identifies the Saturable Hepatic Uptake As a Major Contributor to Its Nonlinear Pharmacokinetics s

Bosentan is a substrate of hepatic uptake transporter organic anion – transporting polypeptides (OATPs), and undergoes extensive hepatic metabolism by cytochrome P450 (P450), namely, CYP3A4 and CYP2C9. Several clinical investigations have reported a non-linear relationship between bosentan doses and its systemic exposure, which likely involves the saturation of OATP-mediated uptake, P450-mediated metabolism
The Complexities of Translating Idioms Across Cultural Boundaries

This research delves into the intricacies of translating idioms, focusing on the transition from English to Albanian. Idioms, deeply rooted in cultural and historical contexts, present significant challenges for translators because of their non-literal meanings and cultural specificity. The study reviews existing literature on idiom translation, highlighting the difficulties translators face and the strategies they use to maintain the authenticity of the source material. The paper identifies essential translation strategies such as paraphrasing, omission, and finding linguistic equivalents crucial in preserving the original text's intended meaning and essence. It emphasizes the importance of cultural understanding and cross-cultural awareness in the translation process, especially when dealing with fixed expressions and idioms that are culturally bound. Through an analysis of the translation of idioms from English to Albanian, the study reveals the need for coherence and careful consideration of linguistic nuances to convey meaningful messages effectively. It discusses conceptual metaphors, the cultural significance of specific motifs (like animals) in English idioms, and their translation into Albanian. Furthermore, the study explores the implications of idiom translation in the context of English as a Foreign Language (EFL) education. It suggests that teaching idioms by connecting them to their cultural origins and incorporating real-life examples can enhance EFL students' language proficiency and cultural understanding. The paper concludes by emphasizing the role of skilled translators in bridging linguistic and cultural gaps and provides references for further exploration of the topic.
Indeﬁnite Kernel Logistic Regression with Concave-inexact-convex Procedure

—In kernel methods, the kernels are often required to be positive deﬁnite, which restricts the use of many indeﬁnite kernels. To consider those non-positive deﬁnite kernels, in this paper, we aim to build an indeﬁnite kernel learning framework for kernel logistic regression. The proposed indeﬁnite kernel logistic regression (IKLR) model is analysed in the Reproducing Kernel Kre˘ın Spaces (RKKS) and then becomes non-convex. Using the positive decomposition of a non-positive deﬁnite kernel, the derived IKLR model can be decomposed into the difference of two convex functions. Accordingly, a concave-convex procedure is introduced to solve the non-convex optimization problem. Since the concave-convex procedure has to solve a sub-problem in each iteration, we propose a concave-inexact-convex procedure (CCICP) algorithm with an inexact solving scheme to accelerate the solving process. Besides, we propose a stochastic variant of CCICP to efﬁciently obtain a proximal solution, which achieves the similar purpose with the inexact solving scheme in CCICP. The convergence analyses of the above two variants of concave-convex procedure are conducted. By doing so, our method works effectively not only under a deterministic setting but also under a stochastic setting. Experimental results on several benchmarks suggest that the proposed IKLR model performs favorably against the standard (positive-deﬁnite) kernel logistic regression and other competitive indeﬁnite learning based algorithms.
The Description Logic Handbook

This introduction presents the main motivations for the development of Description Logics (DLs) as a formalism for representing knowledge, as well as some important basic notions underlying all systems that have been created in the DL tradition. In addition, we provide the reader with an overview of the entire book and some guidelines for reading it. We first address the relationship between Description Logics and earlier semantic network and frame systems, which represent the original heritage of the field. We delve into some of the key problems encountered with the older efforts. Subsequently, we introduce the basic features of DL languages and related reasoning techniques. DL languages are then viewed as the core of knowledge representation systems, considering both the structure of a DL knowledge base and its associated reasoning services. The development of some implemented knowledge representation systems based on Description Logics and the first applications built with such systems are then reviewed. Finally, we address the relationship of Description Logics to other fields of Computer Science.We also discuss some extensions of the basic representation language machinery; these include features proposed for incorporation in the formalism that originally arose in implemented systems, and features proposed to cope with the needs of certain application domains.
Immunotherapeutic IL-6R and targeting the MCT-1/IL-6/CXCL7/PD-L1 circuit prevent relapse and metastasis of triple-negative breast cancer

Rationale: Multiple copies in T-cell malignancy 1 (MCT-1) is a prognostic biomarker for aggressive breast cancers. Overexpressed MCT-1 stimulates the IL-6/IL-6R/gp130/STAT3 axis, which promotes epithelial-to-mesenchymal transition and cancer stemness. Because cancer stemness largely contributes to the tumor metastasis and recurrence, we aimed to identify whether the blockade of MCT-1 and IL-6R can render these effects and to understand the underlying mechanisms that govern the process. Methods: We assessed primary tumor invasion, postsurgical local recurrence and distant metastasis in orthotopic syngeneic mice given the indicated immunotherapy and MCT-1 silencing (shMCT-1). Results: We found that shMCT-1 suppresses the transcriptomes of the inflammatory response and metastatic signaling in TNBC cells and inhibits tumor recurrence, metastasis and mortality in xenograft mice. IL-6R immunotherapy and shMCT-1 combined further decreased intratumoral M2 macrophages and T regulatory cells (Tregs) and avoided postsurgical TNBC expansion. shMCT-1 also enhances IL-6R-based immunotherapy effectively in preventing postsurgical TNBC metastasis, recurrence and mortality. Anti-IL-6R improved helper T, cytotoxic T and natural killer (NK) cells in the lymphatic system and decreased Tregs in the recurrent and metastatic tumors. Combined IL-6R and PD-L1 immunotherapies abridged TNBC cell stemness and M2 macrophage activity to a greater extent than monotherapy. Sequential immunotherapy of PD-L1 and IL-6R demonstrated the best survival outcome and lowest postoperative recurrence and metastasis compared with synchronized therapy, particularly in the shMCT-1 context. Multiple positive feedforward loops of the MCT-1/IL-6/IL-6R/CXCL7/PD-L1 axis were identified in TNBC cells, which boosted metastatic niches and immunosuppressive microenvironments. Clinically, MCT-1high/PD-L1high/CXCL7high and CXCL7high/IL-6high/IL-6Rhigh expression patterns predict worse prognosis and poorer survival of breast cancer patients. Conclusion: Systemic targeting the MCT-1/IL-6/IL-6R/CXCL7/PD-L1 interconnections enhances immune surveillance that inhibits the aggressiveness of TNBC.
Affirmative Action and Equality of Opportunity in College Admissions

This essay critically examines the efficacy of race-based affirmative action in U.S. college admissions, arguing that it fails to adequately address the root causes of racial inequality and often does not benefit the most marginalized individuals within minority groups. By exploring affirmative action through the lens of political philosophy, particularly John Rawls' conception of social justice, the essay contends that a focus on socioeconomic status rather than race would more effectively promote equality of opportunity and align with Rawlsian principles. The analysis draws on various studies and theoretical perspectives to highlight the limitations of race-based affirmative action, including its tendency to benefit economically advantaged members of minority groups and its inadequacy in addressing the diverse and complex backgrounds of individuals within these groups. The essay proposes socioeconomic affirmative action as a more equitable alternative, supported by empirical evidence suggesting that such an approach could increase both socioeconomic and racial diversity in higher education institutions. The conclusion underscores the need for systemic reforms beyond admissions policies to truly achieve a just and equitable society.
Evaluation of Zinc solubilization potential by different strains of Fluorescent Pseudomonads

: Zinc solubilizing ability of Pseudomonas fluorescent was evaluated using zinc oxide, zinc carbonate and zinc sulphide in both plate and broth media assays. Forty bacterial strains and 0.1% of each chemical source in six replications were used. Colony and halo diameters were measured after incubating the plates for 48h in incubator. Zn solubilizing ability of 40 mentioned strains in three replications was studied with ZnO and ZnCO 3 solutions in broth assay. The soluble zinc and pH were measured after five days. The results showed, only 8 of 40 strains could form clearing zone in plate assay. Halo diameter, ratio of the halo diameter to the colony diameter and area respectively for zinc oxide and zinc carbonate were as following, respectively: 0.60- 1.32 cm, 1.20-2.64 and 0.95-2.60 cm 2 , 0.13-1.70 cm, 0.27-2.99 and 0.31-4.10 cm 2 . There were no halos observed in zinc sulphide. The concentration of soluble Zn for ZnO was 28-625 mg/l and pH was shifted from 7.0-7.2 to 3.90-6.50 and for ZnCO 3 was 247-753 mg/l and pH was shifted from 7.0-7.2 to 3.5-6.3 after 5 days of inoculation 28 ºC
Wave‐Particle Interaction of Alfvén Waves in Jupiter's Magnetosphere: Auroral and Magnetospheric Particle Acceleration

We investigate spatial and temporal scales at which wave‐particle interaction of Alfvén waves occurs in Jupiter's magnetosphere. We consider electrons, protons, and oxygen ions and study the regions along magnetic flux tubes where the plasma is the densest, that is, the equatorial plasma sheet, and where the plasma is the most dilute, that is, above the ionosphere, where auroral particle acceleration is expected to occur. We find that within a dipole L‐shell of roughly 30, the electron inertial length scale in the auroral region is the dominating scale, suggesting that electron Landau damping of kinetic Alfvén waves can play an important role in converting field energy into auroral particle acceleration. This mechanism is consistent with the broadband bidirectional electron distributions frequently observed by Juno. Due to interchange‐driven mass transport in Jupiter's magnetosphere, its magnetosphere‐ionosphere coupling is expected to be mostly not in local force balance. This might be a key reason for the dominant role of Alfvénically driven stochastic acceleration compared to the less frequently occurring, locally forced‐balanced, and thus static mono‐energetic unidirectional acceleration. Outside of approximately L = 30, the ion gyroperiod is the dominating scale suggesting that ion cyclotron damping of heavy ions plays a major role in heating magnetospheric plasma. We also present properties of the dispersion relationship and the polarization relationships of kinetic Alfvén waves including the important effects from the relativistic correction due to the displacement current in Ampère's law.
Freshening of the Labrador Sea surface waters in the 1990s: Another great salinity anomaly?

The observed Labrador Sea surface salinities for 1951–2001 in region [55W–40W, 45N–55N] show freshening in the 1990s which may rival the Great Salinity Anomaly (GSA) of the 1970s [ Dickson et al., 1988 ]. The 1990s freshening is distinct in the lowest range of salinity values associated with the coastal waters. The variability of the highest salinity values, provided by the North Atlantic Current entering the Labrador Sea, shows that the high salinity Atlantic waters were not widely present in the 1970's and 1990s. This can be interpreted as weakened transport of saline waters to the area. This explanation is consistent with an Arctic‐North Atlantic model results forced by NCEP/NCAR Reanalysis data (for 1958–2001) which suggest that these periods are associated with a reduced meridional overturning. The model also associates the coastal freshening with southward current anomalies which are well correlated with the number of icebergs crossing 48N.
Interactive X-Ray Vision Mediated Reality

In this poster, we explore a novel approach to improve the spatial perception of embedded virtual objects in a mixed reality environment by manipulating the material appearance of real objects. Addressing the challenge of establishing a perceptually robust connection to the real world in situated visualizations, our approach provides a means for seamlessly integrating virtual objects with their real-world counterparts. This approach, which we refer to as glass phantom rendering, aims, in particular, to improve the perception of containment, emulating the characteristics of real-world glass-encased exhibits in museums. Visual results from our proof-of-concept implementation demonstrate an enhanced perception of virtual objects being embedded inside real-world objects, setting the stage for further exploration to optimize and more deeply explore this and other similar effects in
Collision Resistance from Multi-Collision Resistance for all Constant Parameters

A t -multi-collision-resistant hash function ( t -MCRH) is a family of shrinking functions for which it is computationally hard to find t distinct inputs mapping to the same output for a function sampled from this family. Several works have shown that t -MCRHs are sufficient for many of the applications of collision-resistant hash functions (CRHs), which correspond to the special case of t = 2. An important question is hence whether t -MCRHs for t > 2 are fundamentally weaker objects than CRHs. As a first step towards resolving this question, Rothblum and Vasudevan (CRYPTO ’22) recently gave non-black-box constructions of infinitely-often secure CRHs from t -MCRHs for t ∈ { 3 , 4 } assuming the MCRH is sufficiently shrinking. Earlier on, Komargodski and Yogev (CRYPTO ’18) also showed that t -MCRHs for any constant t imply the weaker notion of a distributional CRH. In this paper, we remove the limitations of prior works, and completely resolve the question of the power of t -MCRHs for constant t in the infinitely-often regime, showing that the existence of such a function family always implies the existence of an infinitely-often secure CRH. As in the works mentioned above, our construction is non-blackbox and non-constructive. We further give a new domain extension result for MCRHs that enables us to show that the underlying MCRH need only have arbitrarily small linear shrinkage (mapping (1 + ϵ ) n bits to n bits for any fixed ϵ > 0) to imply the existence of CRHs.
Lidar-radar synergistic method to retrieve ice, supercooled and mixed-phase clouds properties Answers to referees

The presented work addresses a significant gap in current climate and weather forecasting models by proposing a novel method for retrieving microphysical properties of mixed-phase clouds. Recognizing the limited representation of these clouds due to the complexity of underlying processes, the study leverages airborne or satellite radar and lidar measurements within an extended variational method. The key innovation lies in the simultaneous retrieval of ice and supercooled water properties, achieved by exploiting the distinct sensitivities of lidar and radar signals. The method is rigorously developed, considering the sensitivity of these instruments and relying on a robust a priori framework. Validation using DARDAR-MASK products and airborne in situ measurements demonstrates promising results, showcasing the method’s potential to enhance our understanding of mixed-phase cloud processes. The work is well-structured, providing clear insights into the motivation, methodology, and validation approach, and it contributes significantly to the broader goal of improving climate and weather prediction models. Overall, the research exhibits a commendable quality, combining scientific rigor with practical applicability. The abstract effectively introduces the paper’s focus on addressing the challenges in representing mixed-phase clouds in climate and weather forecasting models. The proposed method for retrieving microphysical properties of mixed-phase clouds is clearly outlined. The use of airborne or satellite radar and lidar measurements, along with a variational method, enhances the understanding of cloud processes. The abstract sets a comprehensive context for the reader, emphasizing the importance of accurate representation of mixed-phase clouds in models. Section 2 is well-written and provides a comprehensive explanation of the methodology. In section 3 the introduction of the ASTAR campaign and the specific context of the study is clear and sets the stage effectively. The integration of in situ measurements and remote sensing data, especially the use of the Polar Nephelometer as a reference, enhances the robustness of the comparison. Section
Thyroid disease.

Procedure Appropriateness Category Relative Radiation Level US thyroid Usually Appropriate O CT neck with IV contrast May Be Appropriate ☢☢☢ CT neck without IV contrast May Be Appropriate ☢☢☢ MRI neck without and with IV contrast Usually Not Appropriate O MRI neck without IV contrast Usually Not Appropriate O I-123 uptake scan neck Usually Not Appropriate ☢☢☢ I-131 uptake scan and Tc-99m pertechnetate scan neck Usually Not Appropriate ☢☢☢☢ CT neck without and with IV contrast Usually Not Appropriate ☢☢☢ FDG-PET/CT whole body Usually Not Appropriate ☢☢☢☢