Miracle-dz/UniFAR-FTUs huggingface dataset:
Stereospecificity of Hydrogen Abstraction in the Conversion of Arachidonic Acid to 15 R -HETE by Aspirin-treated Cyclooxygenase-2 IMPLICATIONS FOR THE ALIGNMENT OF SUBSTRATE IN THE ACTIVE SITE*

The initial and rate-limiting step in prostaglandin biosynthesis is stereoselective removal of the pro- S hydrogen from the 13-carbon of arachidonic acid. This is followed by oxygenation at C-11, formation of the five-membered ring, and a second oxygenation at C-15 to yield the endoperoxide product, prostaglandin G 2 . Aspi- rin treatment of cyclooxygenase-2 is known to acetylate an active site serine, block prostaglandin biosynthesis, and give 15 R -hydroxyeicosatetraenoic acid (15 R -HETE) as the only product. 15 R -HETE and prostaglandins have opposite stereoconfigurations of the 15-hydroxyl. To un-derstand the changes that lead to 15 R -HETE synthesis in aspirin-treated COX-2, we employed pro- R- and pro-S -labeled [13- 3 H]arachidonic acids to investigate the selectivity of the initial hydrogen abstraction. Remark-ably, aspirin-treated COX-2 formed 15 R -HETE with removal of the pro- S hydrogen at C-13 (3–9% retention of pro- S tritium label), the same stereoselectivity as in the formation of prostaglandins by native cyclooxygenase. To account for this result and the change in oxygenase specificity, we suggest that the bulky serine acetyl group forces a realignment of the omega end of the arachidonic acid carbon chain. This can rationalize abstraction of the C-13 pro- S hydrogen, the blocking of prostaglandin
Nuevo procedimiento para la detección precoz y control de la desnutrición hospitalaria

The serious problem of hospital undernutrition is still being underestimated by medical staff of modern hospitals, despite its impact on clinical evolution and hospitalisation costs. The actual system used to detec undernutrition in hospitals depends on doctor’s sensitivity and not even the 10% of the cases that require intrervention are detected. The screening methods developed so far are not useful for daily clinical practice due to their low
Chinese "SHI...DE" focus constructions: an Optimality-Theoretic proposal

This thesis studies SHI . DE focus constructions, or what have been called cleft sentences, in Chinese. The two main goals are to understand the form and function of this type of construction and to account for its syntactic variations. First, I justify previous claims that shi plays a dual role in SHI . DE focus constructions as a contrastive focus marker and as a ThemeRheme separator. Then I put together a set of restrictions on topical Themes in SHI . DE focus constructions, which I call topical Theme conditions. Finally, based on the data, I propose that the form of SHI . DE focus constructions is shaped by the interaction of four syntactic and pragmatic factors-topical Theme conditions, strong topic fronting, word order and a shi rule. These factors are ranked according to their strengths. The availability of such ranking suggests the possibility of using Optimality Theory to account for the form of SHI . DE focus constructions.
The View from SocialyrPersonality Psychology

The emergence of experimental philosophy is fascinating to watch from the vantage point of so ¢ ial! personality psychology. Although experimental philosophy js quite broad, much of it tackles questions that are fundamentally about social psychology and personality, Understanding how social factors influence people's reasoning about morality, agency, and knowledge is, essentially, a social psychological quest・ion, Undcrstanding how and why people differ from each other in their moral behavior and
Optimal trajectories of aircraft and spacecraft

Work done on algorithms for the numerical solutions of optimal control problems and their application to the computation of optimal flight trajectories of aircraft and spacecraft is summarized. General considerations on calculus of variations, optimal control, numerical algorithms, and applications of these algorithms to real-world problems are presented. The sequential gradient-restoration algorithm (SGRA) is examined for the numerical solution of optimal control problems of the Bolza type. Both the primal formulation and the dual formulation are discussed. Aircraft trajectories, in particular, the application of the dual sequential gradient-restoration algorithm (DSGRA) to the determination of optimal flight trajectories in the presence of windshear are described. Both take-off trajectories and abort landing trajectories are discussed. Take-off trajectories are optimized by minimizing the peak deviation of the absolute path inclination from a reference value. Abort landing trajectories are optimized by minimizing the peak drop of altitude from a reference value. Abort landing trajectories are optimized by minimizing the peak drop of altitude from a reference value. The survival capability of an aircraft in a severe windshear is discussed, and the optimal trajectories are found to be superior to both constant pitch trajectories and maximum angle of attack trajectories. Spacecraft trajectories, in particular, the application of the primal sequential gradient-restoration algorithm (PSGRA) to the determination of optimal flight trajectories for aeroassisted orbital transfer are examined. Both the coplanar case and the noncoplanar case are discussed within the frame of three problems: minimization of the total characteristic velocity; minimization of the time integral of the square of the path inclination; and minimization of the peak heating rate. The solution of the second problem is called nearly-grazing solution, and its merits are pointed out as a useful engineering compromise between energy requirements and aerodynamics heating requirements.
2021 Pengaruh Sistem Informasi Akademik (SIKAD) dan Kualitas Pelayanan Terhadap Kepuasan Mahasiswa Pada Universitas Islam

2021 ABSTRACT This reaserch was conducted at the Islamic University of Riau in the city Pekanbaru, researchers wanted to see how the level of student satisfaction with the academic information system (SIKAD) and the quality of services provided by the Islamic University of Riau on student satisfaction, especially in the 2018/2019 class, sample size was taken with slovin obtained 394 students from a total population of 27,733 students, while the respondents were 165 students who responded to the questionnaire from the google form, via student email. Along with the current COVID-19 pandemic which has occurred for more than a year until the time this research is conducted in 2021. The analytical tool used in the study is Smart PLS. 3, with evaluation of measurement model and evaluation of structural model. Based on this analysis, it was found that the academic information system (SIKAD) and service quality had an effect on student satisfaction of 93.1%. The test for the feasibility of the model used with the Normed Fit Index (NFI) of 0.841 means that the model that is owned is fit, is in the marginal fit category because it is at a critical value of 0.8 NFI 0.90. Path coefficients to see the magnitude of the effect of exogenous variables on endogenous variables, with the t-statistics method (bootstrapping) both variables have a positive and significant
Feature Selection Method for Inequality Maximum Entropy

Inequality maximum entropy method has alleviated data sparseness with flexible modeling capability more successfully than other probabilistic models in text classification tasks, but feature selection algorithm used by the model can not fully bring its advantage.This paper proposes a new feature selection method.It improves the recognition rate in text classification.Experimental result shows that this algorithm works more effectively in selecting representative features and improves the text classification performance a lot.
Design Sciences and Technology

This paper analyzes the role of design in start-ups that focus on design as the primary source of value creation. These “design-intensive start-ups” (DIS) have, to-date, received little attention, in either the entrepreneurial or the design related literature. In particular, our explorative study focuses on how do DIS leverage design in the first years of the venture and suggests that this type of start-ups use design to: transform the meaning of the product/service offered, provide a different socio-cultural narrative af how value can be created, incorporate the social-capital in the value proposition. Implications of these findings are discussed.
Responses of reinforced concrete pile group in two-layered liquefied soils: shake-table investigations

During earthquakes, the response of pile foundations in liquefiable sand reinforced by densification techniques is still a very complex dynamic soil-structure interaction problem. Two shake-table experiments were conducted to investigate the behavior of a reinforced concrete (RC) low-cap pile group embedded in liquefiable soils. Discussion is focused on the behavior of soil-pile-superstructure systems prior to and during liquefaction of the medium-dense and dense sand stratums, which are involved in restoring force characteristics at the superstructure and pile group effect. The test results demonstrated a stiffness reduction and dependent nonlinear behavior appearing in the liquefied medium-dense sand; however, an overall stiffening response was observed in liquefied dense sand. The pile group effect seemed insignificant in liquefied medium-dense sand, but was very significant in the liquefied dense sand. 摘要目的探讨中密和密实砂液化场地混凝土低承台群桩和地基动力响应存在的差异性, 并揭示引起这种差异性的原因, 以期获得加密后砂土液化场地混凝土低承台群桩和地基动力反应的基本特征与规律。 创新点1. 利用振动台试验, 成功实施中密和密实砂液化场地低承台群桩基振动台试验; 2. 基于试验结果, 对比中密和密实砂层液化场地群桩和地基的动力响应规律, 考察两种液化场地条件下群桩效应基本特征。 方法1. 通过对比白噪声扫频, 获得中密砂和密实砂层液化场地下体系模态参数的差异性 (图2 和表1); 2. 通过对比砂层孔压、 加速度和位移 (图3-8), 获得中密砂和密实砂液化场地动力反应显著的差异性; 3. 基于上部结构和承台的位移与加速度, 讨论中密砂和密实砂液化场地上部结构动力反应与回复力特性 (图9 和10); 4. 基于桩上记录的应变时程, 考虑桩的非线性, 反算混凝土桩的弯矩时程, 对比两类场地群桩弯矩存在的差异性, 获得两类场地对群桩效应的影响效应 (图12-14)。 结论1. 密实砂液化场地加速度在砂层液化后未出现弱化现象, 表现出明显的循环流动性, 密实砂液化场地比中密砂液化场地刚度更大; 2. 上部结构动力响应与砂土密实状态密切相关; 3. 中密砂液化场地桩的最大弯矩发生在土层分界处, 而密实砂液化场地中桩的最大弯矩发生在桩头处; 4. 群桩效应在密砂层中更显著, 而在中密砂层并不显著。
Design and optimization of a three-terminal piezoresistive pressure sensor for catheter based in vivo biomedical applications

In recent times, catheters with integrated transducers have been extensively investigated in the field of biomedical engineering, especially for use in in vivo neonatal intensive care systems. An integral module of such systems is a blood pressure sensor that must fulfill the competing requirements of high sensitivity and small area. Typically, microelectromechanical systems-based membrane structures with integrated piezoresistors are used to realize such miniaturized blood pressure sensors. Conventionally, the electromechanical transduction of membrane deformation into an equivalent electrical signal is accomplished by piezoresistors connected in a fully active Wheatstone bridge configuration. However, such a configuration requires a large area for the placement of piezoresistors and layout of interconnects. Even though piezoresistors connected in a half-active Wheatstone bridge configuration overcome the area constraint, such an arrangement still suffers from reduced electrical sensitivity. In this paper we propose a novel three-terminal single-element piezoresistor membrane-based miniaturized blood pressure sensor for less than 1 French catheter application. Design and optimization of the sensor is performed using numerical simulations to satisfy the competing requirements of high sensitivity, low structural non-linearity and high mechanical stability. Simulations are carried out to optimize the piezoresistor position, piezoresistor doping concentration and relative dimensions of the piezoresistor and the membrane. Results depict that sensor with a die size of 175 × 150 × 50 μm3 results in an electrical sensitivity of 14.03 μA A–1 mmHg–1. Finally, a set of design guidelines are outlined for optimizing the performance of three-terminal piezoresistor-based blood pressure sensors.
The impact of a vortex ring on a porous screen

In this paper, we re-examine the issue raised by Morton (2000) regarding the impact of a vortex ring on a porous screen. We show, through a systematic experiment, that Morton's observation can only occur at very low Reynolds number or above a certain critical Reynolds number, which is dependent on the porosity of the screen. In particular, we found that a primary vortex ring of moderate Reynolds number impacting a porous screen can also undergo vortex rebound similar to that observed in vortex ring–solid wall interaction. At a higher Reynolds number, the self-induced flow of the primary vortex ring around the axis of symmetry passes through the screen as a jet-like flow, which later regenerates into a new vortex ring of the same sign but weaker circulation. At an even higher Reynolds number, the primary vortex ring has sufficient energy to pass through the screen via a possible mechanism of vortex stretching and reconnection, and continues as a modified ring in its lee.
Cumulative Ductility and Hysteretic Behavior of Small Buckling-Restrained Braces

Cumulative ductility is defined as a ratio of total energy to elastic energy which is dissipated by an element of the structural system during cyclic loading. An element of the structural system is categorized hysteretic if the cumulative ductility factor fulfills certain criteria. This study investigated both analytically and experimentally Small Buckling-Restrained Braces (SBRBs). The core of bracings was modeled using Menegotto-Pinto and bilinear functions. The restrained bracing members were in the shape of square hollow steel section. They were made of the assembly of two L-shaped steel sections. From the experimental study on four SBRB specimens, it was proven that the proposed SBRBs have performed relatively stable hysteretic curves up to two percent of strain and the cumulative ductility factor of 199–450. This value is sufficient for the Buckling-Restrained Brace (BRB) elements as elastoplastic structural components. The comparisons of the hysteretic behaviors resulted by SBRB specimens using the Menegotto-Pinto functions and experiments exhibited good agreements, while the amount of energy dissipated by the SBRB specimens using the bilinear model agreed well with the experimental results. Based on the behavior of the experimental hysteretic, implementing the proposed SBRBs as components in ductile truss system is recommended.
Peripheral signature of altered synaptic integrity in young onset cannabis use disorder: A proteomic study of circulating extracellular vesicles

Abstract Background Rates of Cannabis Use Disorder (CUD) are highest amongst young adults. Paucity of brain tissue samples limits the ability to examine the molecular basis of cannabis related neuropathology. Proteomic studies of neuron-derived extracellular vesicles (NDEs) isolated from the biofluids may reveal markers of neuropathology in CUD. Methods NDEs were extracted using ExoSORT, an immunoaffinity method to enrich NDEs from plasma samples from patients with young onset CUD and matched controls. Differential proteomic profiles were explored with Label Free Quantification (LFQ) mass spectrometry. Selected proteins were validated using orthogonal methods. Results A total of 231 (±10) proteins were identified in NDE preparations from CUD and controls of which 28 were differentially abundant between groups. The difference in abundance of properdin (CFP gene) was statistically significant. SHANK1 (SHANK1 gene), an adapter protein at the post-synaptic density, was nominally depleted in the CUD NDE preparations. Conclusion In this pilot study, we noted a decrease in SHANK1 protein, involved in the structural and functional integrity of glutamatergic post-synapse, a potential peripheral signature of CUD neuropathology. The study shows that LFQ mass spectrometry proteomic analysis of NDEs derived from plasma may yield important insights into the synaptic pathology associated with CUD.
Can Machines Ever Learn from Their Own Mistakes?

Consider the task ofbalancing a broomhandle or pole on an outstretched hand. Could an explanation ofthe task be given such that someone (or something) would be able to do it? This is not a trivial control problem and requires a considerable amount of skill involving sensory and motor coordination. It is also difficult to describe clearly in terms of rules. The pole-balancing problem is important and sheds light on some ofthe issues involved in balancing in general. For example, the complex tasks ofwalking or maintaining the balance ofa rocket in flight. Is it possible to devise a controllerwhich could learn to balance a pole through experience? Considering this question leads to a more general query. Could machines ever discover control strategies for themselves? Such machines would make extremely useful tools. This article will explore some aspects ofmachine learning relevant to control engineering. The pole-balancing problem will be used to illustrate some ofthe issues involved.
Hampton Roads Sea Level Rise Preparedness and Resilience Intergovernmental Pilot Project. Phase 2 Report: Recommendations, Accomplishments and Lessons Learned

3 Introduction . 4 The Hampton Roads Intergovernmental Pilot Project . 6 Process of Selection of the Case Study Location . 7 Process of Selection of Scenarios . 10 Case Study Overview . 13 Watershed Context and Scenarios . 14 Infrastructure at Risk, Dependencies, and Interdependency Evaluation . 18 Conclusion . 31 References . 31
On the equitable distribution of points on the circle

In this thesis, we discuss the problem of breaking a stick representing resources, so that, as recipients arrive one at a time they get approximately even parts. To do this, we model the placement of points evenly distributed on the circle. The thesis is in two parts, firstly a review of the various models including the Stick Breaking model of Erdős, hopping around the circle based on the Steinhaus three gap theorem (with Golden (Fibonacci) hops being optimal), a Binary Splitting model and Random distributions. The second part consists of comparing and contrasting these models using various measures, such as, largest and smallest gap and overall discrepancies. Some of the results we have obtained are; the demonstration that of all uniform distributions, the hop model is the most even, and the random model the least even. We also have found simpler methods for describing the various distributions of points and discrepancy in Stick Breaking, as well as, the Golden hop. A comparison is also made with the distributions in the Benford first digit problem which has led to a novel approach to calculate the first digit distributions other than Benford.
RESEARCH ARTICLE Inﬂammation, Immunity, Fibrosis, and Infection Temporal induction of intestinal epithelial hypoxia-inducible factor-2 (cid:2) is sufﬁcient to drive colitis

Temporal induction of intestinal epithelial hypoxia-inducible factor-2 is a notable feature of inﬂammatory bowel disease and chronic induction of hypoxia-inducible factor (HIF)-1 (cid:2) and HIF-2 (cid:2) (endothelial PAS domain protein 1, EPAS1) play important, but opposing, roles in its pathogenesis. While activa- tion of HIF-1 (cid:2) decreases intestinal inﬂammation and is beneﬁcial in colitis, activation of HIF-2 (cid:2) exacerbates colitis and increases colon carcinogenesis in animal models, primarily due to the role of epithelial HIF-2 (cid:2) in mounting a potent inﬂammatory response. Previous work from our laboratory showed that mice overexpressing intestinal epi- thelial HIF-2 (cid:2) led to massive intestinal inﬂammation and decreased survival. As oxygen homeostasis and HIFs are critical in embryonic development, it is not clear whether the observed intestinal inﬂammatory response was secondary to developmental defects. To address this question, the present study used a mouse model to temporally modulate expression of intestinal epithelial HIF-2 (cid:2) to assess its role in mediating inﬂammatory response. Remarkably, activation of HIF-2 (cid:2) in intestinal epithelial cells in adult mice increased expression of proinﬂammatory mediators; however, no decrease in survival was observed. Furthermore, in an acute model of colitis, activation of HIF-2 (cid:2) was sufﬁcient to exacerbate colitis. These data conﬁrm our previous ﬁnding that epithelial HIF-2 (cid:2) mediates inﬂammatory response and demonstrates that activation of HIF-2 (cid:2) is sufﬁcient to exacerbate colitis. HIF-1 (cid:2) has well-characterized protective roles in IBD; however, the role of HIF-2 (cid:2) has been less studied. Using novel HIF-2 (cid:2) mouse models, we show that activation of HIF-2 (cid:2) in intestinal epithelial cells is sufﬁcient to exacerbate colitis.
Influencia del consumo moderado de cerveza sobre la toxicocinética del aluminio: estudio agudo

Objective: Aluminium has lately been implicated as one of the possible causal factors contributing to Alzheimer’s disease and other neurodegenerative disorders due to this metal is conducive to oxidative stress in the brain. According to different researches, it has been suggested that silicon may interfere in the toxicokinetic of this metal. The present study has examined the effect of beer consumption as a source of silicon on the bioavailability of aluminium and the possible role of beer consumption in averting aluminium’s neurotoxicity. Material and methods: In a three-day study, male rats were subjected to acute exposure to aluminium while being given two types of beer, i.e., alcoholic and non-alcoholic beer, to drink at two intake levels, one equivalent to moderate to low consumption in humans (0.5 l/d; 27.5 g alcohol/d) and another equivalent to moderate to high consumption in humans (1 l/d; 55 g alcohol/day). Aluminium and silicon were determined by ICP-MS and ICPOES, respectively. Results: The results obtained seem indicate that at moderately high levels of alcoholic beer intake the silicon present in the beer was able to reduce aluminium uptake in the digestive tract, increasing its excretion by faecal route. In addition, a possible interaction of both elements at level of distribution and renal excretion is suggested. Conclusion: In consequence, moderate beer consumption, possibly affording a protective factor for the toxic effect of aluminium, one of the environmental factors for Alzheimer’s disease.
Optimal local laws and CLT for the circular Riesz gas

We study the long-range one-dimensional Riesz gas on the circle, a continuous system of particles interacting through a Riesz (i.e inverse power) kernel. We establish near-optimal rigidity estimates on gaps valid at any scale. Leveraging on these local laws and using a Stein method, we provide a quantitative Central Limit Theorem for linear statistics. The proof is based on a mean-field transport and on a fine analysis of the fluctuations of local error terms through the study of Helffer-Sj\"ostrand equations. The method can handle very singular test-functions, including characteristic functions of intervals, using a comparison principle for the Helffer-Sj\"ostrand equation.