Miracle-dz/UniFAR-FTUs huggingface dataset:
Renin-Angiotensin System: Updated Understanding and Role in Physiological and Pathophysiological States

The classical view of the renin-angiotensin system (RAS) is that of the circulating hormone pathway involved in salt and water homeostasis and blood pressure regulation. It is also involved in the pathogenesis of cardiac and renal disorders. This led to the creation of drugs blocking the actions of this classical pathway, which improved cardiac and renal outcomes. Our understanding of the RAS has significantly expanded with the discovery of new peptides involved in this complex pathway. Over the last two decades, a counter-regulatory or protective pathway has been discovered that opposes the effects of the classical pathway. Components of RAS are also implicated in the pathogenesis of obesity and its metabolic diseases. The continued discovery of newer molecules also provides novel therapeutic targets to improve disease outcomes. This article aims to provide an overview of an updated understanding of the RAS, its role in physiological and pathological processes, and potential novel therapeutic options from RAS for managing cardiorenal disorders, obesity, and related metabolic disorders.
The Predictive Values of White Blood Cell Indices (Lymphocyte and Eosinophilic Granulocyte) for Heart Failure in Acute Coronary Syndrome Patients Following Percutaneous Coronary Intervention: A Prospective Cohort Study

Background White blood cell (WBC) indices are strongly associated with cardiovascular disease, but data on the prognostic values of these parameters in patients with acute coronary syndrome (ACS) following percutaneous coronary intervention (PCI) are sparse. The current study aimed to investigate the relationship between baseline WBC indices levels and the incidence of heart failure (HF) in ACS patients after PCI and explore the predictive values over a 2-year follow-up period. Methods A total of 416 consecutive ACS patients treated with PCI were enrolled and received a median of 27.7 months follow-up. Univariate and multivariate Cox regression analyses and the receiver operating characteristic (ROC) curves were performed. Results Baseline lymphocyte (LYMPH) count, eosinophil (EO) count and eosinophil percentage (EO %) were higher in patients who experienced HF over a 2-year follow-up. In multivariate Cox proportional hazards analysis, LYMPH count, EO count and EO % were independently associated with the occurrence of HF (hazard ratio [HR] = 12.876, P = 0.025; HR = 16.625, P = 0.004; HR = 1.196, P = 0.031, respectively). The area under the ROC curve of baseline EO count predicting the occurrence of HF in ACS patients following PCI was 0.625 (P = 0.037). For patients aged 60 years and above, who had PCI or history of coronary artery bypass grafting, the higher EO count, the higher the risk of HF. Conclusion Elevated baseline LYMPH count, EO count and EO % were independently associated with the incidence of HF in ACS patients following PCI, suggesting that WBC indices might be available, simple, and cost-efficient biomarkers with predictive value, especially for patients aged more than 60 years.
Boosting internal quantum efficiency via ultrafast triplet transfer to 2H-MoTe2 film

Organic systems often allow to create two triplet spin states (triplet excitons) by converting an initially excited singlet spin state (a singlet exciton). An ideally designed organic/inorganic heterostructure could reach the photovoltaic energy harvest over the Shockley-Queisser (S-Q) limit because of the efficient conversion of triplet excitons into charge carriers. Here, we demonstrate the molybdenum ditelluride (MoTe2)/pentacene heterostructure to boost the carrier density via efficient triplet transfer from pentacene to MoTe2 using ultrafast transient absorption spectroscopy. We observe carrier multiplication by nearly four times by doubling carriers in MoTe2 via the inverse Auger process and subsequently doubling carriers via triplet extraction from pentacene. We also verify efficient energy conversion by doubling the photocurrent in the MoTe2/pentacene film. This puts a step forward to enhancing photovoltaic conversion efficiency beyond the S-Q limit in the organic/inorganic heterostructures.
血浆EB病毒DNA载量监测对单倍体造血干细胞移植后淋巴细胞增殖性疾病的预测价值

目的 寻找可以协助诊断单倍体造血干细胞移植（haplo-HSCT）后淋巴细胞增殖性疾病（PTLD）的EB病毒DNA（EBV-DNA）载量及其持续时间的最佳临界值。 方法 回顾性分析北京大学血液病研究所2016年1月至12月期间haplo-HSCT后合并EBV感染患者的相关数据，通过构建ROC曲线计算约登指数寻找对PTLD有诊断意义的EBV-DNA载量及其持续时间的临界值。 结果 共纳入94例患者，其中20例（21.3％）发生PTLD，诊断PTLD时中位EBV-DNA载量为70 400（1 710～1370 000）拷贝/ml，EBV血症中位持续时间为23. 5（4～490）d。 二元logistic回归分析显示，PTLD组与非PTLD组两组间EBV-DNA最高载量及EBV血症持续时间差异均有统计学意义（P＝0.018，P＝0.001）。 构建ROC曲线计算约登指数，EBV-DNA载量≥41 850拷贝/ml对PTLD有诊断意义［曲线下面积（AUC）＝0.847］，敏感度、特异度分别为0. 611、0.932；EBV血症持续时间≥20.5 d对PTLD有诊断意义（AUC＝0.833），敏感度、特异度分别为0. 778、0.795。 结论 动态监测haplo-HSCT后PTLD高危患者的EBV载量及关注其持续时间有重要临床意义，有助于预测PTLD的发生并早期采取干预措施。
Increase in convective extreme El Niño events in a CO2 removal scenario

Convective extreme El Niño (CEE) events, characterized by strong convective events in the eastern Pacific, are known to have a direct link to anomalous climate conditions worldwide, and it has been reported that CEE will occur more frequently under greenhouse warming. Here, using a set of CO2 ramp-up and ramp-down ensemble experiments, we show that frequency and maximum intensity of CEE events increase further in the ramp-down period from the ramp-up period. These changes in CEE are associated with the southward shift of the intertropical convergence zone and intensified nonlinear rainfall response to sea surface temperature change in the ramp-down period. The increasing frequency of CEE has substantial impacts on regional abnormal events and contributed considerably to regional mean climate changes to the CO2 forcings.
应用二代流式细胞术和二代测序评估多发性骨髓瘤微小残留病比较

Comparison of next-generation flow cytometry and next-generation sequencing in the assessment of minimal residual disease in multiple myeloma Wang Qingqing,Yao Li,Zhu Mingqing,Yan Lingzhi, Jin Song, Shang Jingjing, Shi Xiaolan, Zhai Yingying, Yan Shuang, Yao Weiqin, You Hongying, Wu Depei, Fu Chengcheng Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, NHC Key Laboratory of Thrombosis and Hemostasis, the First Affiliated Hospital of Soochow University, Suzhou 215000, China Corresponding author: Fu Chengcheng, Email: fuchengchengsz@163.com
Analgesic Effect of Passive Range-of-Motion Exercise on the Healthy Side for Pain after Total Knee Arthroplasty: A Prospective Randomized Trial

Background Exercise can reduce the pain threshold momentarily and induce analgesia, which is called exercise-induced hypoalgesia (EIH). Exercise therapy for inducing EIH may be an effective treatment option for pain. We aimed at investigating whether continuous passive motion (CPM) on both healthy and affected sides could induce EIH and reduce pain in the operated knee in patients after unilateral total knee arthroplasty (TKA). Patients and Methods. In this prospective randomized controlled trial, participants were randomly assigned to two groups: a bilateral group that received bilateral exercise on the operated and healthy sides and a unilateral group that received exercise therapy only on the affected side. We enrolled 40 patients aged ≥60 years who were scheduled to undergo unilateral TKA. Visual analogue scale (VAS) scores and range of motion (ROM) on the operated side were measured immediately before and after CPM on postoperative days 2, 4, 7, and 14. The primary outcome was the difference in the VAS scores before and after CPM on postoperative day 14. The secondary outcome was the difference in the ROM before and after CPM on postoperative day 14. Results Comparison of VAS scores before and after CPM showed no significant intergroup differences on all measurement dates. However, there was a significant difference in values on day 14 (P < 0.05). Both groups showed an increase in ROM after CPM, with significant increments observed on days 2 and 4 in the bilateral group and on day 14 in the unilateral group. There was no significant difference in values on postoperative day 14. Conclusion Post-TKA pain was reduced by performing the same exercise on the healthy knee during CPM therapy. This could be due to EIH, and the results indicated that EIH can also influence postoperative pain immediately after surgery.
Why final obstruent devoicing is weakening

widely held right up to the present day (see for example Iverson & Salmons 2007). There is a less well established view that the process is rather one of lenition or weakening. Although this view is not always explicitly presented as such, it is inherent in proposals to treat final devoicing in terms of feature reduction or deletion (see for example Mascaró 1987, Brockhaus 1995, Lombardi 1995, Jessen & Ringen 2002). The present paper has two main goals. The first is to show that the available evidence clearly favours the weakening account of final devoicing. The second is to present a unified model of phonological strength that unequivocally classifies final devoicing as weakening. Of course it all depends on what we mean by strengthening and weakening. Like most scientific generalisations, the notion of strength in phonology is a metaphor. Its initial value flows from the way it allows us to put a name to a set of generalisations that would otherwise go unexpressed. This brings us to the first of the three main reasons I will present for rejecting the strengthening account of devoicing: it subverts important generalisations we can otherwise make about processes that uncontrovertibly do count as weakening, such as debuccalisation and spirantisation. The generalisations concern (i) the phonetic impact of weakening, (ii) the otherwise general tendency for final position to promote weakening and (iii) the way in which final devoicing sometimes interacts directly with weakening processes in the same language. The other two reasons for rejecting the strengthening account coincide with the two main arguments used to support it. One is based on the observation that obstruent voicing, such as commonly occurs intervocalically, is clearly a weakening process. Since devoicing apparently has the opposite phonetic effect, so the argument goes, it should surely be viewed as strengthening. The other argument takes the form of a claim that devoicing strengthens final obstruents in order to demarcate the right edge of words (Iverson & Salmons 2007). As I will try to show below, neither of these arguments is particularly convincing. The first is based on a faulty conception of voicing as an entity that remains uniform across different segment types and phonological contexts. The second is based on the questionable assumption that processes with a demarcative function are necessarily strengthening in nature. If strength is to be more than pure metaphor, we need to establish whether it correlates with any known phonetic property and whether it has any unitary presence in phonological representation. It is widely supposed that strength has a basis in sonority or degree of articulatory aperture. Neither of these definitions provides us with a unified
The Prevalence of Migraine in Inflammatory Bowel Disease, a Systematic Review and Meta-Analysis

Background: Patients with inflammatory bowel disease (IBD) suffer from a wide range of comorbidities such as migraine. In studies, the prevalence of migraine in cases with IBD was reported differently. The goal of this systematic review and meta-analysis was to estimate the pooled prevalence of migraine in IBD cases. Methods: Two researchers independently and systematically searched PubMed, Scopus, EMBASE, Web of Science, and google scholar. They also searched the gray literature including references of the included studies and conference abstracts which were published up to May 2021. Cross-sectional studies were included. Results: The literature search revealed 840 articles, and after deleting duplicates, 650 remained. For the meta-analysis, 10 studies were included. Totally, 62,554 patients were evaluated. The pooled prevalence of migraine in patients with IBD was 19% (95% CI: 15–22%). The pooled prevalence of migraine in ulcerative colitis (UC) was 10% (95% CI: 4–15%) (I2 = 99.8%, P < 0.001). The pooled prevalence of migraine in the Crohn's disease (CD) group was 24% (95% CI: 17–30%) (I2 = 98.8%, P < 0.001). The pooled odds of developing migraine in IBD cases was 1.51 (95% CI: 1–2.27) (I2 = 90.8%, P < 0.001). Conclusions: The result of this systematic review and meta-analysis showed that the pooled prevalence of migraine in patients with IBD was 19% (95% CI: 15–22%).
Outcome of Obstructed Total Anamalous Pulmonary Venous Connection (TAPVC) Repair Patients with Milrinone Versus Milrinone and Inhaled Nitric Oxide (INO): A Prospective Randomized Observational Study

ABSTRACT Background: Obstructed total anomalous pulmonary venous connection (TAPVC) typically present with severe cardiovascular decompensation and requires urgent surgical management. Pulmonary arterial hypertension (PAH) is a major risk factor affecting mortality. Perioperative management focuses on providing inotropic support and managing potential pulmonary hypertensive episodes. Milrinone and inhaled nitric oxide (iNO) efficiently reduce pulmonary artery pressure (PAP) and help to improve the outcome. The aim was to determine the outcome of patients with high PAP with milrinone alone and a combination of iNO and milrinone. Material and Method: After ethical committee approval, the study was conducted over a period of 3 years in 80 patients with obstructed TAPVC repair. A total of 80 patients having severe PAH (supra systemic arterial pressure) randomly divided into two groups with 40 patients in each (M & MN). Group M (milrinone) patients received milrinone and Group MN (milrinone & iNO) patients received both milrinone (after opening aortic cross clamp) and iNO (post operative ICU). Ventilation time, hospital stay, ICU stay, complications, in hospital mortality were compared between both groups. Result: Ventilation time, Intensive Care Unit (ICU) stay, hospital stay for group M was 8.02 ± 5.74 days, 11.25 ± 7.33 day, 14.92 ± 8.55 days, respectively, and for group MN was 5.02 ± 1.78 days, 8.27 ± 3.24 days, 10.3 ± 3.18 days, respectively. In hospital mortality for group M and MN was 10% and 2.5%, respectively. P value for each variable was significant < 0.05 (except mortality). Conclusion: Most of the patients with obstructed TAPVC had severe PAH. Management of severe PAH with a combination of milrinone with iNO had a better outcome than milrinone alone.
STRUCTURED ROBUST STABILITY ANALYSIS OF AN INVERTED PENDULUM SYSTEM WITH A FIXEDFEEDBACK

Robust stability analysis of inverted pendulum system with a fixed linear quadratic feedback is carried out using µ analysis tools. A mathematical model of inverted pendulum system is presented and linearized about the desired equilibrium point. A linear quadratic control feedback matrix is used in the configuration of the nominal inverted pendulum system for its stabilization. After this, uncertainties in the inverted pendulum with a fixed feedback, is modeled in linear fractional transformation form , which is suitable for structured singular value computation. Both parametric and modeling uncertainties are considered in the inverted pendulum system. After deriving out uncertain system model, mixed µ analysis method which is a structured uncertainty analysis method, is used to compute the uncertainty bound that does not cause instability of the inverted pendulum under feedback. A simulation test for validity of the results is provided.
急性淋巴细胞白血病微小残留病检测与临床解读中国专家共识（2023年版）

Chinese consensus on minimal residual disease detection and interpretation of patients with acute lymphoblastic leukemia (2023) Laboratory Diagnosis Group, Chinese Society of Hematology, Chinese Medical Association Corresponding author: Wu Depei, the First Affiliated Hospital of Soochow University, National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, Suzhou 215006, China, Email: wudepei@suda.edu.cn; Huang Xiaojun, Peking University People's Hospital, Peking University, Institute of Hematology, National Clinical Research Center for Blood Diseases, Beijing 100044, China, Email: huangxiaojun@bjmu. edu.cn
Comparison of Radioactive Iodine Activities in Terms of Short- and Long-term Results in Ablation Therapy in Patients with Low-risk Differentiated Thyroid Cancer

Objectives: The aim of this study was to compare the treatment responses after ablation with 30-50 mCi radioactive iodine (RAI) and 100 mCi RAI in patients with differentiated thyroid cancer (DTC) who were in the low-risk group according to 2015 American Thyroid Associations Classification (ATA 2015) criteria. Methods: Between February 2016 and August 2018, 100 patients who received RAI treatment in our clinic after total thyroidectomy and who were in the low-risk group DTC were included in this retrospective study. These patients were divided into 2 groups: low-activity (30-50 mCi) (group 1) and high-activity (100 mCi) (group 2). While 54 patients were treated with low activity, 46 patients received high activity RAI. The 2 groups were compared according to the 1st- and 3rd-year treatment response status. Results: According to the first-year follow-up, 15 patients were accepted as indeterminate response and 85 patients as excellent response. Three (5.5%) of the patients who were accepted as indeterminate response were in group 1 and 12 (26%) were in group 2. According to the third year follow-up, 1 patient in group 1 and 3 patients in group 2 were accepted as indeterminate response. No biochemical incomplete response or recurrent disease was detected. In the chi-square analysis performed to investigate the relationship between the first-year treatment response and RAI activities, a significant relationship was found (p=0.004). In the Mann-Whitney U test performed to investigate the parameters that may be effective in the treatment response, only the preablative serum thyroglobulin value was shown to have a significant difference between the two groups (p=0.01). In the long-term follow-up of the patients, based on the third year treatment response data, chi-square analysis was performed to evaluate the two groups in terms of treatment responses, and no statistically significant relationship was found (p=0.73). Conclusion: Ablation with 30-50 mCi can be safely applied in DTC patients who are in the ATA 2015 low-risk group and are planned for RAI ablation treatment.
Making invisible visible - Electron tomography shows a lattice surface layer in whole-mounts of Lactobacillus brevis

Department of Pathology, Haartman Institute, P.O. Box 21, FI-00014 University of Helsinki, Finland Nanomicroscopy Center, Department of Applied Physics, P.O. Box 3500, FI-02150 Aalto University School of Science and Technology, Espoo, Finland Department of Biomedical Engineering & Computational Science, P.O. Box 9203, FI-02015 Aalto University School of Science and Technology, Finland Department of Physics, P.O. Box 64, FI-00014 University of Helsinki, Finland Department of Basic Veterinary Sciences, P.O. Box 6, FI-00014 University of Helsinki, Finland Corresponding author, Peter.Engelhardt@Helsinki.Fi
Adaptive Exponential Stabilization of Chained Form Systems with Application to Mobile Robot

This paper investigates the adaptive stabilization problem for chained form systems with strong nonlinear drifts. A parameter separation technique is introduced to transform the nonlinear parameterized system into a linear-like parameterized system. Then, using the parameter separation, input-state-scaling technique and integrator backstepping procedure, an adaptive state feedback controller is obtained. The adaptive control based switching strategy is proposed to eliminate the phenomenon of uncontrollability. Global exponential regulation of the closed-loop system and the boundedness of other signals are guaranteed. The proposed scheme can be applied to the adaptive control of mobile robot with small angle measurement error. Simulation results demonstrate the validity of the presented algorithm.
Sun protection, progress, myths, and inconsistencies (a proposal for the democratization of ISO 24443)

The concept of modern human sun protection is no more than one hundred years, but real development of it, including protection against UVA + UVB radiation (and more recently also the IR and blue light), has been no more than 30 years. One fundamental issue while formulating sunscreens is the photostability of the UV filters, which is particularly feeble for the UVA. The gold standard for the determination of sunscreen UVA protection “in vitro” is ISO 24443:2021. Still, interlaboratory results are not as consistent as expected. The Technical Committee for Cosmetics (ISO TC 217) has tried to standardize the method with precise specifications for the materials and equipment used. In particular, the standardization of UV exposure sources based on Xe arc lamps. This fact requires expensive equipment out of the reach of many laboratories to achieve adequate temperature control on the samples. In this paper, it will be shown that, within the experimental error, satisfactory results were achieved with a cheap commercial LED source irradiating only in the UVA spectra. Evidence is presented to conclude that other more relevant factors must be considered as the main cause of uncertainties.
A review about the role of additives in nerve tissue engineering: growth factors, vitamins, and drugs

Abstract Notably the integration of additives such as growth factors, vitamins, and drugs with scaffolds promoted nerve tissue engineering. This study tried to provide a concise review of all these additives that facilitates nerve regeneration. An attempt was first made to provide information on the main principle of nerve tissue engineering, and then to shed light on the effectiveness of these additives on nerve tissue engineering. Our research has shown that growth factors accelerate cell proliferation and survival, while vitamins play an effective role in cell signalling, differentiation, and tissue growth. They can also act as hormones, antioxidants, and mediators. Drugs also have an excellent and necessary effect on this process by reducing inflammation and immune responses. This review shows that growth factors were more effective than vitamins and drugs in nerve tissue engineering. Nevertheless, vitamins were the most commonly used additive in the production of nerve tissue. Graphical Abstract
FGF homologous factors are secreted from cells to induce FGFR‐mediated anti‐apoptotic response

FGF homologous factors (FHFs) are the least described group of fibroblast growth factors (FGFs). The FHF subfamily consists of four proteins: FGF11, FGF12, FGF13, and FGF14. Until recently, FHFs were thought to be intracellular, non‐signaling molecules, despite sharing structural and sequence similarities with other members of FGF family that can be secreted and activate cell signaling by interacting with surface receptors. Here, we show that despite lacking a canonical signal peptide for secretion, FHFs are exported to the extracellular space. Furthermore, we propose that their secretion mechanism is similar to the unconventional secretion of FGF2. The secreted FHFs are biologically active and trigger signaling in cells expressing FGF receptors (FGFRs). Using recombinant proteins, we demonstrated their direct binding to FGFR1, resulting in the activation of downstream signaling and the internalization of the FHF‐FGFR1 complex. The effect of receptor activation by FHF proteins is an anti‐apoptotic response of the cell.