Miracle-dz/UniFAR-FTUs huggingface dataset:
Mathematical Modeling of Flow and Diffusion in the Lens of the Eye

The present work is concerned with the development of a simple transient mathematical model for the oxygen diffusion-consumption in the eye lens. The model takes into account the transport of oxygen by diffusion and consumption of oxygen is assumed to follow the Michaelis- Menten’s kinetics. The partial differential equation governing the partial pressure of oxygen has been solved by using implicit Crank-Nicholson’s iteration scheme. The prime objective of the present study is to investigate the effect of model parameters: the Michaelis- Menten’s kinetic constant and maximum rate of consumption on the partial pressure of oxygen in the mammalian lens. The computational results of the model have been presented by graphs and effects of model parameters also have been shown through the graphs and discussed. The present mathematical analysis of oxygen diffusion in the lens may contribute to the knowledge of regulation of tissue oxygen in the lens and quantitative understanding achieved through the analysis may facilitate the design of new therapeutic procedures. This analysis may help in regulating the partial pressure of oxygen in the lens.
Suppression of NF- k B Activation by Infection with Toxoplasma gondii

The interaction of host cells with microbial products or their invasion by pathogens frequently results in activation of the NF- k B family of transcription factors. The studies presented here reveal that in vivo, infection with Toxoplasma gondii results in the activation of NF- k B. To determine whether host cells could activate NF- k B in response to invasion by T. gondii, Western blots, immunoﬂuorescence, and electrophoretic mobility shift assays were used to assess the response of host cells to infection. In these studies, infection of macrophages or ﬁbroblasts with T. gondii did not result in the activation of NF- k B. In addition, the ability of lipopolysaccharide to activate NF- k B was impaired in cultures of macrophages infected with T. gondii . Together, these data demonstrate that invasion of cells by T. gondii does not lead to the activation of NF- k B and suggest that the parasite may actively interfere with the pathways that lead to NF- k B activation.
OTT_A_264394 11537..11547

1Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, People’s Republic of China; 2Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, People’s Republic of China Background: This study aimed at probing into the effect of long non-coding RNA (lncRNA) C-terminal binding protein 1 antisense RNA 2 (CTBP1-AS2) on gastric cancer (GC) cell proliferation and apoptosis, and its regulatory function on miR-139-3p and MMP11. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to examine the expressions of CTBP1-AS2, miR-139-3p and MMP11 mRNA in GC cell lines and clinical specimens. Cell counting kit-8 (CCK-8) assay, flow cytometry and EdU assay were conducted to examine the effects of CTBP1-AS2 and miR-139-3p on GC cell proliferation and apoptosis. Western blot was applied for detecting the expressions of Bax, Bcl-2 and MMP11. A lung metastasis mouse model was used to evaluate metastasis of GC cells in vivo. Bioinformatics, dual-luciferase report assay, RIP and RNA pull-down assays were utilized to validate the targeted relationship between CTBP1-AS2 and miR-139-3p as well as the targeting relationship between miR-139-3p and MMP11. Results: CTBP1-AS2 was highly expressed in GC, and its high expression was strongly associated with increased TNM stage, increased tumor size and low degree of differentiation of the tumor tissues. Meanwhile, CTBP1-AS2 promoted GC cell proliferation, metastasis and suppressed apoptosis, while miR-139-3p could weaken these effects. In addition, CTBP1AS2 was identified as a molecular sponge for miR-139-3p, and MMP11 was verified as a target gene of CTBP1-AS2. CTBP1-AS2 could increase the expression of MMP11 via repressing miR-139-3p. Conclusion: CTBP1-AS2 promotes GC cells and inhibits apoptosis by regulating the miR139-3p/MMP11 molecular axis.
URANS Predictions of Mixing Enhancement with Steady and Pulsed Control Jets

URANS CFD predictions are reported for a single round jet at high Reynolds number and high subsonic Mach number (Re = 10 6 , M = 0.9) excited by steady and pulsed control jets (CJs). Comparison has been made with experimental validation data to assess the ability of k-ε based URANS modelling for predicting CJ-driven flow control of near-field jet mixing and potential core length reduction. The well-known overprediction of the clean (unexcited) core length with this level of turbulence closure remains, but, taking this into account, the relative effect of CJs on core length reduction was predicted remarkably well. For example, steady CJs and pulsed CJs in symmetric/antisymmetric modes indicated a core length reduction (relative to the unexcited case) of 43%/45%/60% in CFD predictions, compared to 48%/40%/51% in measurements. Comparison of radial profiles showed that URANS modelling was also able to predict the 3D near field behaviour induced by CJs throughout the jet cross-section. The vortex structures produced in the pulsed CJ predictions were compared. Symmetric and antisymmetric modes produced different vortex structures; these caused different levels of enhanced mixing in the two azimuthal modes, and explained the better performance of antisymmetric pulsing.
The Design of User-Centric Mobile Crowdsensing with Cooperative D2D Communications

Ubiquitous sensor-rich smartphones have promoted MCS, an emerging people-centric sensing paradigm for urban IoT. However, using cellular networks to transmit the big data collected by MCS would incur expensive financial costs for both participating phone users and the MCS organizer. A promising solution to this is to integrate the low-cost D2D communication into the MCS design. However, using D2D in MCS will require cooperative interactions among self-interested and strategic participating phone users, which significantly complicates the “human-in-the-loop” MCS design in both the digital and human dimensions, and brings a branch of new challenges: data communication and networking become more complex; D2D connections among opportunistically encountered phone users must be secure, fast, and user-transparent; and participating phone users need to be properly incentivized. In dealing with these challenges, this article covers recent developments of D2D-enabled MCS from both the theoretical and practical perspectives. Future research questions in this rapidly growing field are also discussed.
Home Medication Regimens Increase in Complexity After Admission for Fall in the Older Trauma Patient

Background Hospitalization for the older trauma patient is an opportunity to assess polypharmacy. We hypothesized that medication regimen complexity (RxCS) and pain medication prescriptions (PRxs) would increase in older home-going patients admitted for a fall. Methods We retrospectively chart reviewed patients ≥45 years old admitted for a fall at a level 1 trauma center who were discharged home with full medication documentation. RxCS was compared pre-admission and post-discharge with Wilcoxon signed-rank tests; opioid and non-opioid PRxs were compared with Fisher’s exact test, α = . 05. Results 103 patients met inclusion criteria; 58% were ≥65 years old. RxCS (9 [.5-13] to 11 [4.5-15], P < .01) increased on discharge. Opioid PRx rates increased significantly in all age groups. Non-opioid PRx rates increased significantly for patients <65 but not for patients ≥65. Conclusions Admission for a fall was associated with increases in RxCS, while PRx changes were age-dependent. Providers should recognize that admissions for older patients who fall after trauma are underutilized opportunities to address polypharmacy in high-risk patients.
Cronin effect at RHIC

The Cronin effect is studied with identified particle spectra from 200GeV d+Au collision at RHIC. The nuclear modification factor RdAu of baryons (proton etc.) rise faster than those of mesons (pions, kaons and phi etc.) and show a baryon/meson scaling behavior similar to that found at Au+Au collisions at same energy. The particle‐species dependence of the Cronin effect is observed to be significantly smaller than that at lower energies. The eta asymmetry is also reported and shows contrary trends to prediction based on initial multiple parton scattering model. These measurements indicate that the final state effect plays an important role in the Cronin effect.
Relaxations of the 3-partition problem

Preface In order to obtain a master's degree, all I have to do is answer the last question at my final presentation. Before I will be allowed to answer it, however, a number of tasks have to be performed. One of them is writing this thesis. In order to be able to write this thesis, I needed something to write about. I have been in the fortunate position to be able to do research on a quite wide variety of subjects. Most of this research was carried out at the computer science department of the Radboud University Nijmegen. I was situated in the formal methods group, a very inspiring environment. Aliated with this group-and a reason I chose this group-is Hans Zantema. Hans Zantema is a professor at Eindhoven University of Technology, and part time so at Radboud University Nijmegen. As such, Hans Zantema was my supervisor during the course of my master's research. Hans Zantema proved to be a great supervisor for me. Hans was able to inspire me into investigating a great variety of problems. While discussing my progress, Hans would find new angles, new questions or solutions. By gently steering me in the right direction, Hans was a tremendous help to keep me focused. My supervisor at my own university, the University of Twente, was Walter Kern. Walter has also been a great help in the research I did. Like Hans, Walter was able to come up with creative angles to look at problems. An important contribution of Walter was to introduce me to bin packing games. This turned out to be a very fruitful research direction, which ultimately led to the main part of this thesis. For writing this thesis, I decided to make a selection of results obtained during my research. In making this decision, I selected a central topic that could serve as a backbone for related results. This central topic is the 3-partition problem. In particular, the nearly-feasible instances, a type of infeasible 3-partition problem for which a certain half-integral relaxation has a solution. Before I started writing this thesis, I have written an article on this very topic [9]. I wrote this together with my supervisor Hans Zantema, and it is currently in submission. For me, writing this article has been a great practice. In addition, it allowed me to obtain some focus while doing this research. There are, however, some major …
Optimal multi-epoch combination of direct imaging observations for improved exoplanet detection

Exoplanets detection by direct imaging remains one of the most challenging field of modern astronomy. The signal of the star can prevent the detection of orbiting companions in single datasets, but combining information from several observations helps boost the detection limits. We propose a new algorithm named PACOME, based on PACO’s approach, which optimally combines, in a maximum likelihood sense, multi-epoch datasets and improves the detection sensitivity of potential exoplanets by taking into account their orbital motions. The efficiency of the algorithm is tested on the well-known exoplanetary system 51 Eridani.
European Data Protection Regulation and the Blockchain Analysis of the Critical Issues and Possible Solution Proposals

—The blockchain represents an Internet revolution in terms data usage, storage, anonymity, encryption, and so on. The technical evolution of the blockchain also has an impact on the Internet of Things (IoT) phenomena. However, we should take into account the legal issues related to the data protection and privacy law. Technological solutions are welcome, but it is necessary, before developing applications, to consider the risks to the fundamental rights and freedoms which we cannot dismiss. Personal data is a value. It is important to evaluate the European Regulation n. 2016/679, General Data Protection Regulation (GDPR) that applies from May 25th 2018. The GDPR introduces Data Protection by Design and by Default, Data Protection Impact Assessment (DPIA), data breach notiﬁcation and signiﬁcant administrative ﬁnes in respect of infringements of the Regulation. It is fundamental to evaluate the blockchain and its compliance with the GDPR principles. Regarding the data protection and security risks, there are some issues with potential consequences for data and liability. A correct law analysis allows evaluating risks preventing the wrong use of personal data. The contribution describes the main general principles according to the GDPR and the aspects related to the blockchain.
Lapse risk in life insurance contracts

We investigate the drivers of lapses in life insurance contracts of a large Italian insurance company. We consider both traditional (with proﬁt or participating) and unit-linked policies. We develop two diﬀerent types of analyses. First of all, we investigate the determinants of lapse decisions by policyholders looking at microdata on each contract. Then, through a panel study, we include macroeconomic variables. We show that the determinants of lapses for the two types of contracts are quite diﬀerent. No evidence supporting the Interest Rate Hypothesis, i.e. a positive correlation between interest and lapse rates, is detected. Instead some evidence that a positive correlation of lapse rates with personal ﬁnancial/economic diﬃculties, also known as the Emergency Fund Hypothesis, emerges. Some behavioral ﬁnance insights come out.
ACQUIRING L2 PRONOUN INTERPRETATION BIASES IMPLICIT LEARNING AT THE DISCOURSE LEVEL IN L2 ENGLISH

Learners of a nonnull subject language (e.g., English) whose ﬁ rst language (L1) is a null subject language (e.g., Spanish) can show some optionality in the interpretation of overt subject pronouns in the second language (L2). By exposing L2 learners to nativelike interpretations of pronouns in discourse, we aim at understanding how exposure can promote implicit learning of pronoun comprehension biases in a L2. A sentence comprehension task was used with intermediate-pro ﬁ ciency English L2 speakers (L1 Spanish) that included a pretest, an exposure phase using the priming technique,animmediateposttest,andadelayedposttestadministered6 – 10dayslater.Englishlearners showed a signi ﬁ cant increase in nativelike pronoun interpretations both in the immediate posttest and in the delayed posttest, in comparison to the pretest. The results show that exposure through priming can be effective in changing L2 participants ’ interpretations and that effects of exposure are persistent and may aid in the successful acquisition of pronoun resolution biases.
Comparative analysis of sensitivity coefficient using traditional beta of CAPM and downside beta of D-CAPM in automobile manufacturing companies

The main purpose of this research was to compare the two widely-used pricing models, capital asset pricing model (CAPM) and downside capital asset pricing model (D-CAPM), in the automobile manufacturing industry so as to suggest more suitable model that can be used to estimate the expected return rate in such industries. The comparison was made through defining four hypotheses each focusing on the risk premium correlation rate as an independent variable with the expected return in the two models, CAPM traditional beta and D-CAPM downside beta, the expected return rate of the two models, and finally the deviation rate of the expected return from the realized return in both models. The statistical results of testing the hypotheses proved the superiority of D-CAPM over CAPM to determine the expected return rate in automobile manufacturing companies.
HOMOLOGY STABILTY FOR THE SPECIAL LINEAR GROUP OF A FIELD AND MILNOR-WITT K-THEORY

Let F be a ﬁeld of characteristic zero and let f t,n be the stabilization homomorphism H n (SL t ( F ) , Z ) → H n (SL t +1 ( F ) , Z ). We prove the following results: For all n , f t,n is an isomorphism if t ≥ n + 1 and is surjective for t = n , conﬁrming a conjecture of C-H. Sah. f n,n is an isomorphism when n is odd and when n is even the kernel is isomorphic to I n +1 ( F ), the ( n + 1)st power of the fundamental ideal of the Witt Ring of F . When n is even the cokernel of f n − 1 ,n is isomorphic to K MW n ( F ), the n th Milnor-Witt K -theory group of F . When n is odd, the cokernel of f n − 1 ,n is isomorphic to 2 K M n ( F ), where K M n ( F ) is the n th Milnor K -group of F .
Identification of the lactate threshold and the blood glucose threshold in resistance exercise

The purpose of this study was to verify the possibility of identifying the blood glucose threshold (GT) as well as to compare and correlate the GT with the lactate threshold (LT) during resistance exercises. healthy male volunteers aged 24.4 ± 1.2 years and adapted to resistance training were submitted to an incremental resistance exercise with graded intensities according to their maximal workload (kg) performed for 1 repetition (1RM) on both leg press (LP) and bench press (BP). The intensities applied for each 1 min stage were of 10%, 20%, 25%, 30%, 35%, 40%, 50%, 60%, 70%, 80% and 90% of 1RM, respectively, or until volitional exhaustion. Blood lactate and glucose measurements were done each 2 min rest between each stage ( YSI 2300 S). The blood lactate and glucose responses were similar for both exercises. No differences were verified for the relative intensity (% 1RM) at which the inflection point of blood lactate and glucose curves were observed respectively for LP (36.6 ± 1.4% and 32.9 ± 1.5%) and BP (31.2 ± 1.2% and 31.2 ± 1.8%) (p > 0.05). Additionally, a high correlation was verified between LT and GT identified both on LP (r = 0.80) and SR (r = 0.73) (p < 0,05). It was concluded that it is possible to identify the LT and GT on resistance exercises. However, additional studies should investigate the meaning of these thresholds and their validity for exercise evaluation and training prescription.
Control of the lateral Casimir force between corrugated surfaces (4 pages)

The general perturbative expression for the lateral Casimir force between two plates covered by longitudinal corrugations of arbitrary shape is obtained. This expression is applicable for corrugation periods larger than the separation distance. The cases of asymmetric corrugations are considered, which allow one to increase the maximum to minimum force ratio and affect the character of equilibrium points. This opens opportunities to control the lateral Casimir forces for use in microelectromechanical devices based entirely on the vacuum fluctuation properties.
Genetic diversity and connectivity of Beveridge Reef's marine biodiversity in an Indo-Pacific wide context

This report contributes a genetic diversity survey of representative marine reef species of Beveridge Reef and Niue. Population genetic (mtDNA) sequence data was generated for five species collected from Beveridge Reef and Niue: the surgeonfishes, Acanthurus nigrofuscus , Acanthurus triostegus ; the grouper, Cephalopholis argus ; the urchin, Echinometra mathaei ; and the clam, Tridacna maxima . This data was combined with existing genetic datasets provided by the Diversity of the Indo-Pacific Network (DIPnet, http://diversityindopacific.net/), and available in the publicly accessible Genomic Observatory Metadatabase (GeOMe, www.geome-db.org). The compiled data was analysed to describe the genetic diversity, genetic uniqueness, and genetic distinctiveness of Beveridge Reef relative to Niue and other Indo-Pacific locations.
Neglected cardiovascular risk factors.

Download the Issue @ a Glance podcast Subscribe to the EHJ Podcast ! [Graphic][1] Obesity and the metabolic syndrome are highly prevalent conditions. The metabolic syndrome not only precedes cardiovascular conditions, and hence represents an important cluster of risk factors,1,2 but also remains relevant in patients with established coronary artery disease and heart failure and other cardiovascular conditions.3 It is still unclear, if—in the setting of cardiac dysfunction—it represents an adverse risk factor for clinical outcomes. The obesity paradox complicates the definition of its role in these patients.4–6 The epidemiological implications of metabolic syndrome in heart failure have been studied intensely, as many of its components contribute to the incidence and severity of heart failure. In particular, insulin resistance, diabetes mellitus, and lipid abnormalities represent the main components that contribute to disease progression. Yet, other components of the metabolic syndrome, i.e. overweight and obesity as well as high blood pressure, are favourably associated with outcome in heart failure. This complex interaction of risk factors is extensively discussed in a timely Clinical Review entitled ‘ The role of metabolic syndrome in heart failure ’ by Pasquale Perrone-Filardi from the Federico II University of Naples in Italy.7 Proper identification of subjects at increased risk for cardiovascular events plays a central role in our efforts to improve the prevention and management of cardiovascular disease and to decrease the related costs. Despite their high predictive value on a population level, traditional risk factors fail to predict individual risk fully. Thus, the discovery of novel risk markers remains an unmet need. In the second … [1]: /embed/inline-graphic-1.gif
COMPARATIVE ANALYSIS OF ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY TREATMENT METHODS FOR HEPATIC ECHINOCOCCOSIS INVASION IN BILIARY TRACT WITHOUT JAUNDICE

: Objectives: To investigate the clinical effect of radical resection of ERCP(Endoscopic retrograde cholangiopancreatography) in patients with hepatic Echinococcosis and biliary tract without jaundice, the research was carried out in Qinghai province at Qinghai university Affiliated hospital. The objectives of study were to assess Comparative analysis of ERCP treatment methods for hepatic Echinococcosis invasion and biliary tract without jaundice Methodology: A nalysis of 29 cases of hepatic bubble hydatid invasion and biliary tract without jaundice treated by our department from January 2015 to March 2018, according to the different treatment methods, 9 cases (experimental group) and radical resection of patients with ERCP+ENBD were divided into 20 cases with radical resection of two-stage lesions ( Control group), the operation time of each group, the amount of blood loss during operation, the biliary leakage of postoperative complications, the average length of hospital stay, the average hospitalization cost, the median time of carrying peritoneal drainage tube after operation, preoperative, 3 days after operation, 7 days ALT, AST, ALP, and other liver work indexes were analyzed. Results: There was no significant difference between the two groups in the average length of hospital stay, average hospitalization cost, general data (sex, age, location of lesion, size of lesion, etc.), liver function index before and after operation (AST, albumin, PT, INR, 3 days after Operation ALP, AST, albumin, PT and INR, etc.). 0.05). However, there was a statistically significant difference between postoperative biliary complications (biliary leakage) and the median time of postoperative drainage tube (P<0.05). Conclusion: For hepatic bubble hydatid invasion and biliary tract without jaundice, the first stage of ERCP+ENBD, two-stage lesion radical resection can significantly reduce the occurrence of postoperative biliary complications (biliary leakage), and ERCP+ENBD has the advantages of minimally invasive, simple, safe surgical technique in liver resection patients