Miracle-dz/UniFAR-FTUs huggingface dataset:
Master ’ s Final Project Mode of action elucidation studies of new antimicrobial compounds

1 1.INTRODUCTION . 2 1.1. THE HISTORY OF ANTIMICROBIALS . 2 1.2. ANTIMICROBIAL RESISTANCE . 4 1.3. MYCOBACTERIUM TUBERCULOSIS: A GLOBAL PRIORITY FOR ANTIMICROBIAL DISCOVERY . 6 1.4. MECHANISMS OF ANTIMICROBIAL RESISTANCE . 7 1.4. 1.Drug inactivation . 8 1.4. 2.Target overexpression . 8 1.4. 3.Target modification . 8 1.4. 4.Target replacement . 9 1.4. 5.Reduced antimicrobial uptake . 9 1.5. DISCOVERY OF NEW ANTIMICROBIALS . 9 1.5. 1.Hit identification . 10 1.5. 2.Hit to lead . 11 1.6. EXPERIMENTAL APPROACHES TO ELUCIDATE THE MODE OF ACTION OF ANTIMICROBIALS . 12 1.7. DRUG REPURPOSING . 13 1.8. AVERMECTINS . 15 1.9. EPMM COMPOUNDS . 16 2.OBJECTIVES . 17 3.MATERIALS AND METHODS . 18 3.1. BACTERIAL STRAINS, GENERAL GROWTH CONDITIONS AND PRESERVATION . 18 3.1.1.Bacterial strains . 18 3.1.2.Growth conditions . 19 3.1.3.Strain preservation . 19 3.2. COMPOUNDS . 19 3.3. ANTIMICROBIAL SUSCEPTIBILITY TESTING . 20 3.3.1.Broth microdilution susceptibility testing . 20 3.3.2.Minimal Bactericidal Concentration determination . 21 3.3.3.Time-kill kinetics . 21 3.4. MYCOBACTERIUM SMEGMATIS MUTANT ISOLATION . 22 3.4. 1.Mutant isolation in agar plates . 22 3.4. 2.Validation of the resistant phenotype . 22 3.5. SCREENING OF THE MYCOBACTERIUM BOVIS BCG TNSPAZ TRANSPOSITION LIBRARY . 23
High-dimensional decoy-state quantum key distribution over 0.3 km of multicore telecommunication optical ﬁbers

made towards QC using high-dimensional quantum systems encoded into the transverse momentum of single photons but, so far, no approach has been proven to be fully compatible with the existing telecommunication infrastructure. Here, we overcome such a technological challenge and demonstrate a stable and secure high-dimensional decoy-state quantum key distribution session over a 0.3 km long multicore optical ﬁber. The high-dimensional quantum states are deﬁned in terms of the multiple core modes available for the photon transmission over the ﬁber, and the decoy-state analysis demonstrates that our technique enables a positive secret key generation rate up to 25 km of ﬁber propagation. Finally, we show how our results build up towards a high-dimensional quantum network composed of free-space and ﬁber based links. key bit generation probability up to 25 km of ﬁber propagation. Last, we clarify that our technique is fully compatible with research towards quantum communications based on OAM encoded high-dimensional quantum states. We show that a new interface device can be constructed that allows the eﬃcient coupling of 4-dimensional OAM quantum states into multicore ﬁbers. That is, the device allows for the eﬃcient mapping of OAM-encoded to core-path-encoded quantum states, and vice-versa. The device is a modiﬁed version of previous reported OAM mode sorters [25], which is now suitable for multicore ﬁber conﬁgurations. These results pave the way towards a high-dimensional quantum network composed of interconnected free-space and optical ﬁber links.
RADIATION L E U K E M I A IN C57BL/6 MICE III. Correlation of Altered Expression of Terminal Deoxynucleotidyl Transferase to Induction of Leukemia* Be

Whole-body irradiation of a variety of inbred strains of mice has been shown to induce thymic lymphomas (1-3). Although considerable research has been directed at the etiology of radiation-induced leukemia in strains of mice such as C57BL, the factors involved are still problematical. Initially it was proposed that primary tumors in irradiated mice were induced by the activation of a latent endogenous C-type virus, based on the observation that leukemogenic viruses could be obtained by continued passage of cell-free extracts (4-6). However, detailed serological and virological studies have demonstrated that there is little correlation between endogenous ecotropic virus expression and induction of leukemia by irradiation in C57BL/6 mice (7-9). Moreover, irradiation induces leukemia in mice such as the NIH Swiss (10) and C57L (11) which genetically lack an endogenous ecotropie C-type virus. Serological and structural analyses of the virus isolated from radiation-induced leukemia indicate that this virus may be a recombinant virus which may have developed after the primary event of radiation-induced leukemia (12). Thus, it appears that the primary etiological factor in radiation-induced leukemia does not involve complete endogenous ecotropic C-type virus expression. Therefore, this disease is quite distinct from the spontaneous leukemias in AKR mice, which are more clearly associated with active replication of endogenous ecotropic C-type viruses (13, 14). In spite of the lack of a consistent etiological factor associated with radiationinduced leukemia, a number of biological phenomena have been described for radiation-induced leukemias which bear directly on the possible mechanisms of induction. First, the regimen of irradiation has been shown to be extremely important (3), in that a single irradiation of 350 rads is only weakly leukemogenic, whereas four weekly doses of 175 rads is highly leukemogenic. This observation argues against a simple mechanism of somatic mutation and supports a more complex inductive mechanism (6). A second observation is that the primary leukemogenic effects are in the bone marrow. This is illustrated by the ability to block the leukemogenic effect of whole-body irradiation by shielding the legs (15) and by the observation that early after irradiation, preleukemic cells can be transferred to appropriate recipients by bone marrow cells but not by thymocytes (16). This effect is also evident by the ability to induce leukemia in thymeetomized mice which have received a normal thymus
Optimum Path Planning for Multi Mobile Robots with Speed of Work Achievement as Constrain

This paper presents optimum path planning for multi mobile robots that move between an initial point toward a target point then back to the initial point in a way that avoid collision without heavily slow down robots speed. The work system designs for taking into consideration robots velocities as well as time that robots will spend it in their target points, since both could be variant for all robots. In order to achieve the work objectives, time and space method combined with sequential entry method are used to design robots motion. In addition, two priority levels are used of carefully selected priorities to avoid collision between robots; node level priority and robot level priority. In node level priority, the priority gives to robots in a manner that minimize the number of over all system collisions. While in robot level priority the priority gives to robots that cause faster speed for work achievement. The work is tested with different number of robots and different types of maps, and the algorithm proved its efficiency in finding the optimum solution regarding system performance for each robot in the collision points. The proposed algorithm is implemented using VBA programming language.
Investigation of Power Quality in a Hybrid Power System- The case of Paros island complex

This paper examines the power quality of the nine islands complex in Aegean Sea (Paros island complex), which are connected to each other by submarine cables. The power supply of this island complex is provided by a power station (DIESEL) of nominal power 79.43 MW and by renewable energy plants (6 wind farms totaling 13.960 kW) and 34 photovoltaic stations totaling 2982.745 kW, which are located in the islands of the complex. Due to the structure power generation and distribution system in this island complex, it has been considered necessary to study the power quality, which is affected mainly by the connection and disconnection of renewable energy sources as well as the physical characteristics of these sources. The influence of variations in the power parameters of the renewable sources and the harmonic content of electrical quantities were critical issues to be investigated at two selected locations for reasonable time intervals. The assessment of the power quality was done in accordance with the international standards and mainly according to the standard EN 50160. The DRANETZ measurement system recorded the attributable power / energy of the renewable sources and corresponding time plots were formed for the time periods of measurements. Also have been recorded interruptions and reconnections of renewable sources with the grid. It was found that all the standard claims were met and taken in account the experience of the system operator we had concluded that in the island complex the quality was satisfactory. The aim of this investigation was to extract useful information about the power quality and to show how have to work in practice to evaluate the power quality .
Investigating the Application of Project Management Principles to Research Projects – An Exploratory Study

The management of research projects can be subject to significant uncertainty due to the knowledge creation process that is undertaken. The systematic investigation of a research area requires adoption of a scientific approach along with an appropriate level of creativity and this can present certain challenges in regard to managing research projects. Project management has developed to support industrial projects in areas such as construction, manufacturing and information technology. Therefore, the question arises: Are the standardized techniques of project management adequate to support effective delivery of research projects that involve a high level of knowledge based activities? This paper will report on the results of an exploratory study based on a systematic literature review, which has been carried out in order to improve our understanding of the key features and issues arising from the application of project management principles to research projects. The literature has been considered in regard to the process, structure, people and technology dimensions. The paper includes synthesis of a proposed research agenda in order to advance the knowledge base on the management of research projects.
A Novel Approach Towards Time Sensitive Data

Privacy and confidentiality of data stored in public cloud have been a major issue since cloud storage first came up. Various technologies have been used to protect the data in the cloud. It is an issue in relation to cloud storage. It frees information owners because he has no responsibility of providing information to any expected clients. Hence the need for consistent surveillance and constant security practices. To preserve the integrity of the data, researchers have proposed multiple methods to ensure data security. In any case, until this time, no plans to intensify both fine-grain ability to control and possible control. In this project, client and author ("the evil dictator") are not able to access the data without the client's use of a given secret key. Another enhanced feature is being highlighted here where a technical back up account can grant access to data users. The CPABE policy has been adapted for the storage of private electronic data.
Determining systematic differences in human graders for machine learning-based automated hiring

Firms routinely utilize natural language processing combined with other machine learning (ML) tools to assess prospective employees through automated resume classification based on pre-codified skill databases. The rush to automation can however backfire by encoding unintentional bias against groups of candidates. We run two experiments with human evaluators from two different countries to determine how cultural differences may affect hiring decisions. We use hiring materials provided by an international skill testing firm which runs hiring assessments for Fortune 500 companies. The company conducts a video-based interview assessment using machine learning, which grades job applicants automatically based on verbal and visual cues. Our study has three objectives: to compare the automatic assessments of the video interviews to assessments of the same interviews by human graders in order to assess how they differ; to examine which characteristics of human graders may lead to systematic differences in their assessments; and to propose a method to correct human evaluations using automation. We find that systematic differences can exist across human graders and that some of these differences can be accounted for by an ML tool if measured at the time of training.
Austin Biometrics and Biostatistics Region-Based Tests for Association Analysis of Rare Variants

Despite numerous discoveries based on genome wide association studies of common variants, the heritability of most complex traits remains largely unexplained. Rare variants may play a significant role in disease risk and phenotypic variation. Such variants are known to be associated with mendelian disorders and rare forms of common diseases. They are also known to be associated with complex diseases. Dramatic advances in DNA sequencing technologies have enabled a more comprehensive evaluation of the full spectrum of genetic variation and now enable us to evaluate the role of low frequency and rare variation in complex traits. In this review, I provide an overview of the various methods that are available for testing simultaneous association of multiple rare variants with disease or any other phenotypes in the context of sequencing based association studies. The tests focus on rare variation from a particular genomic region such as a gene and its surrounding regions. I discuss the basic underlying ideas behind many currently available approaches for region-based association testing of rare variants as well as their advantages and limitations.
Model-based Run-Time Software Adaptation for Distributed Hierarchical Service Coordination

- Dynamic software adaptation addresses software systems that need to change their behavior at run-time. A software adaptation pattern models how the components that make up an architecture pattern cooperate to change the software configuration at run-time. This paper describes a model-based run-time adaptation pattern for distributed hierarchical service coordination in service-oriented applications, in which multiple service coordinators are organized in a distributed hierarchical configuration.
TOURISM DEVELOPMENT OF OHRID (NORTH

The study investigates the current level of tourism development of Ohrid by applying the Tourism Area Life Cycle (TALC) model. The main aim is to assess how much the city has changed due to tourism expansion. In this line, the research explores each TALC stage by an in-depth analysis of Ohrid’s urban transformation. By employing qualitative and quantitative data, the study deeply elaborates many secondary sources along with the TALC model. The results point that some parts of Ohrid (like the old town) is experiencing negative reshaping as a result of tourism, thus provoking unsustainable quantitative growth in a spatially limited, non-expandable, and particularly fragile segment. The general findings indicate that over the years, tourism in Ohrid has exceeded its carrying capacity, beginning to cause damage to the social, cultural, and environmental fabric of the city. Hence, the study recommends that local tourism decision-makers must shift the focus of tourism policy towards qualitative growth, or Ohrid will either lose its environmental balance or its authenticity and livability, and most likely both.
NMD SERVER: NATURAL MEDICINES DATABASE FOR DRUG DISCOVERY

Cancer is the most frequently diagnosed disease globally and the second leading cause of the death. Natural Medicines are the alternative form of treatment that includes use of various plants. It is one of the safe treatment option to treat cancer and safer than allopathic medicines in order to reduce side effects. NMD Server: Natural Medicines Database for Drug Discovery is a unique and significant database of its kind, giving researchers, medical practitioners, pharmaceutical industries and students of Life Sciences an instant access to over 354 records of Natural Medicines which may be developed and used for treatment of Cancer. This database constitutes the specific information related to Natural Medicines and their respective target sites. NMD Server: Natural Medicines Database for Drug Discovery provides all the information (database fields) regarding the physiological parameters of database and is considered to be the linked table with pre-determined values and names that are included to aid in populating the fields of the linked tables. There have been many different types of fields with its respective data types that have been designated on the basis of data provided. NMDdock Tools have been integrated in this database for convenience for users like docking analysis of target and natural medicine, Sensitivity & Specificity analysis of natural medicine, Linear Correlation and Regression tool, Sequence Manipulation of target, Statistical Analysis. For the precise information about any particular drug, connectivity has been made with other databases and applications based highly bioinformatics tools have been embedded for convenience of users. Article DOI: https://dx.doi. org/10.20319/lijhls.2017. 32.216224 This work is licensed under the Creative Commons Attribution-Non-commercial 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA.
Suicidal digoxin intoxication in 61 year old patient

: Digoxin is one of the oldest drugs used in cardiology. It belongs to subgroup of cardiac glycosides. Currently, due to limited indications for use, cases of poisoning with this group of drugs are becoming less common. Ease of poisoning results from the low therapeutic index and symptoms of intoxication may include many different systems. The most serious symptoms of overdose are cardiac arrhythmias. We present a case of a patient with suicide poisoning due to ingestion of 30 tablets of 0.1mg digoxin.
HYPOTHYROIDISM SYMPTOMS AND SIGNS

: Objective: The objective of this research work is to assess the most frequent symptoms of hypothyroidism in patients with medical detection of the underactive thyroid gland due to insufficient production of the thyroid hormones proved by the tests of laboratory. Methodology: This research was carried out in Mayo Hospital Lahore in the duration of thirteen months. All the patients were suffering of probable under active thyroid gland depending on the symptoms of this disease were the part of this study. Tests of radioimmunoassay & evaluation of thyroid hormones production carried out. Interview carried out to record the symptoms and information of demography. SPSS software was in use for the collection of information. Results: The interview for three times carried out of fifty patients who finished questionnaires during the period of this research work. Female were greater in quantity than male. The most frequent signs were intolerance from cold, gain of weight & menorrhagia. The most frequent symptoms were pallor & edema. The serious nature of this disease was present in four patients. Mild type presentation was the most common appearance of the hypothyroidism about sixty percent. Conclusions: The most frequent symptoms & signs of underactive thyroid in the centre regions of Pakistan glands were very different from the outcomes of other studies. The condition of nourishment & Social demography, the level of illiteracy and personnel hygiene are some of the possible reasons. Unluckily, coexistence of some signs & symptoms are not the associate with underactive thyroid gland. It shows that valid medical and laboratory results are the only authentic procedures for the detection of the underactive thyroid gland.
A simple assembly planner for the insertion of ring-shaped deformable objects

Purpose The aim of this work is to develop a simple planner that is able to automatically plan the motion for a dual-arm manipulator that assembles a ring-shaped elastic object into a cylinder. Moreover, it is desirable to keep the amount of deformation as small as possible, because stretching the object can permanently change its size thus failing to perfectly fit in the cylindrical part and generating undesired gaps between the object and the cylinder. Design/methodology/approach The assembly task is divided in two parts: assembly task planning and assembly step planning. The first one computes key configurations of the robot’s end-effectors, and it is based on a simple heuristic method, whereas the latter computes the robot’s motion between key configurations using an optimization-based planner that includes a potential-energy-based cost function for minimizing the object’s deformation. Findings The optimization-based planner is shown to be effective for minimizing the deformation of the ring-shaped object. A simple heuristic approach is demonstrated to be valid for inserting deformable objects into a cylinder. Experimental results show that the object can be kept without deformation for the first part of the assembly task, thus reducing the time it is being stretched. Originality value A simple assembly planner for inserting ring-shaped deformable objects was developed and validated through several experiments. The proposed planner is able to insert ring-shaped objects without using any sensor (visual and/or force) feedback. The only feedback used is the position of the robot’s end-effectors, which is usually available for any robot.
Formulation and Evaluation of Microspheres: A Review

: The use of microspheres circumvents all of the disadvantages that are encountered while using powders and granulates. Pharmaceuticals embedded in the Microsphere matrix are released continuously and at a constant rate. Microspheres are free-flowing and roll with practically no friction that means there is no abrasion, guaranteeing a dust-free environment. Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers having a particle size ranging from 1-1000 μm. The range of techniques for the preparation of microspheres offers a Variety of opportunities to control aspects of drug administration and enhance the therapeutic efficacy of a given drug. The term nano-spheres are often applied to the smaller spheres (sized 10 to 500 nm) to distinguish them from larger microspheres.
Use of Mobile Devices in Teaching and Learning in Traditional Higher Institutions in Nigeria

Studies have shown that using smart mobile devices for teaching and learning tends to complement the traditional method of teaching in schools, enhance active learning, and supports problem solving abilities of students. The main objectives of this study are to identify the level of awareness on possibility of the use of Smart (mobile) devices in learning higher institutions; if any, the extent of utilization of Smart (mobile) devices in education; the factors influencing the extent of utilization; and the strategies for effective utilization of Smart (mobile) devices in higher education in Nigeria. Data was collected by means of a survey from 135 students on full-time study in higher institutions. The data collected was analyzed using the SPSS software. Statistical methods and processes are used to evaluate the strength of relationships between the variables measured at various levels. The result of analysis indicated that students’ ownership of and readiness to use their own mobile device is a critical success factor in the implementation of m-learning. This is because it phases out the issue of cost of providing the device for the students and resolves the issues concerned with usability which was earlier identified as a challenge to m-learning.
UNIVERSAL OPTIMALITY AND FOURIER INTERPOLATION

the results of the paper “Universal optimality of the E 8 and Leech lattices and interpolation formulas” by H. Cohn, A. Kumar, S.D. Miller, D. Radchenko, and M. Viazovska, that is about to appear in Annals of Mathematics.