Miracle-dz/UniFAR-FTUs huggingface dataset:
Peramalan Harga Gandum di Tengah Invasi Rusia ke Ukraina dengan Pendekatan Intervensi Fungsi Step

Semenjak konflik antara Federasi Rusia dan Ukraina terjadi, perekonomian dunia terdampak cukup parah terutama harga komoditas dunia. Akibat dari perang di Ukraina, beberapa rantai-pasok komoditas pangan dunia mengalami hambatan, hingga berujung pada krisis pangan di sejumlah wilayah di Afrika dan mulai merambat ke beberapa negara khususnya di Asia. Gandum merupakan salah satu komoditas pangan yang mengalami kenaikan harga akibat dari konflik yang terjadi di Ukraina. Kenaikan harga gandum tersebut berdampak pula terhadap kenaikan harga produk turunan dari gandum, seperti tepung yang merupakan bahan baku pembuatan roti dan mie. Produk mie dan roti di Indonesia merupakan salah satu makanan pokok pengganti nasi, sehingga jika kondisi kenaikan harga gandum tidak diatasi, dikhawatirkan akan terjadi krisis pangan di Indonesia. Penelitian ini akan memodelkan dan memprediksi harga gandum dunia di tengah konflik antara Rusia dan Ukraina dengan pendekatan model intervensi fungsi step. Hasil penelitian menunjukkan bahwa prediksi harga komoditas gandum dunia di tengah invasi Rusia ke Ukraina dengan pendekatan model intervensi fungsi step menunjukkan hasil yang akurat. Model ARIMA(1,1,0) dengan b=0, s=2, dan r=2 menjadi model intervensi fungsi step paling baik. Nilai MAPE yang ditentukan dari pengujian data adalah 14,27%.
Cirurgia de Whipple: Indicação e Técnicas.

Exploramos a cirurgia de Whipple, uma intervenção cirúrgica complexa utilizada no tratamento de tumores pancreáticos e condições periampulares. Discutimos sua história, técnicas cirúrgicas, aprimoramentos e evolução ao longo dos anos. Abordamos as complicações associadas à cirurgia de Whipple, incluindo fístulas pancreáticas, hemorragias, estenoses de anastomose e infecções pós-operatórias, destacando a importância da prevenção e manejo adequado dessas complicações. Exploramos o tratamento adjuvante, como a quimioterapia, que tem o objetivo de reduzir o risco de recorrência do câncer de pâncreas após a cirurgia. Discutimos os cuidados paliativos como parte fundamental do tratamento para pacientes em estágios avançados ou metastáticos do câncer de pâncreas, enfatizando a importância de aliviar sintomas, melhorar a qualidade de vida e fornecer apoio emocional e social. Abordamos a necessidade de uma abordagem personalizada no tratamento do câncer de pâncreas, levando em consideração o estágio da doença e as necessidades individuais do paciente. Concluímos que o tratamento do câncer de pâncreas é um desafio multifacetado, e a combinação de cirurgia, tratamento adjuvante e cuidados paliativos desempenha um papel crucial na melhoria da qualidade de vida e no aumento das chances de sucesso terapêutico para os pacientes.
Lipid reprogramming induced by the NNMT-ABCA1 axis enhanced membrane fluidity to promote endometrial cancer progression

Elucidating the mechanism for the high metastasis capacity of Endometrial cancer (EC) is crucial to improve treatment outcomes of EC. We have recently reported that nicotinamide N-methyltransferase (NNMT) is overexpressed in EC, especially in EC, and predicts poor survival of chemotherapy patients. Here, we aimed to determine the function and mechanism of NNMT on metastasis of EC. Additionally, analysis of public datasets indicated that NNMT is involved in cholesterol metabolism. In vitro, NNMT overexpression promoted migration and invasion of EC by reducing cholesterol levels in the cytoplasm and cell membrane. Mechanistically, NNMT activated ABCA1 expression, leading to cholesterol efflux and membrane fluidity enhancement, thereby promoting EC's epithelial-mesenchymal transition (EMT). In vivo, the metastasis capacity of EC was weakened by targeting NNMT. Our findings suggest a new molecular mechanism involving NNMT in metastasis, poor survival of EC mediated by PP2A and affecting cholesterol metabolism.
Recreation Specialization and Related Concepts in Leisure Research

More than 40 years have passed since Shafer (1969) challenged the existence of the “average camper. ” Recognizing that participants in recreation activities are heterogeneous in their commitments and interests, researchers have emphasized the importance of differentiating users into meaningful homogeneous subgroups. In his seminal article, Bryan (1977) coined the concept of recreation specialization as one approach for identifying, describing, and planning for these subgroups of recreationists. He defined specialization as “a continuum of behavior from the general to the particular, reflected by equipment and skills used in the sport and activity setting preferences” (Bryan, 1977, p. 175). At one end of this continuum are novices or infrequent participants who do not consider the given activity to be a central life interest or show strong preferences for equipment or technique. The other end of this continuum includes more avid participants who are committed to the given activity and use more sophisticated approaches. Recreationists have been thought to progress to higher stages along this continuum reflected by increasing skill, equipment, participation, and commitment (Bryan, 1977), although this assumption has come under some scrutiny (e.g., Kuentzel & Heberlein, 2008). Since Bryan’s (1977) original work, more than three decades of empirical research examining recreation specialization has improved the understanding of diversity within
Educational Endeavours and Unheeded Tales: Mapping Trajectories of Dalit Women in a University

This article analyses the nature of the relationship between scientific research, gender, and caste questions. It aims to present the lived experiences of Dalit women scholars in science from a sociological perspective. Masculinist, self-fashioned gendered ideologies have dominated the scientific practice of natural sciences in general. The participation of Indian women in scientific research is a very recent phenomenon. Women students from marginalised communities are almost invisible in so-called egalitarian educational institutions. They are deprived of academic resources and opportunities and are subjected to constructive discrimination based on their intersectional identity. This study attempts to unfold the lived experiences of Dalit women scholars, particularly in the scientific laboratories, through a feminist perspective. The study is based on Dalit women scholars from a central university in South India. In-depth interviews have been employed as tool of data collection and observed through the lens of feminist perspective. The study found that women scholars from marginalised sections were meagrely represented in science research. The unique experiences of Dalit women scholars have been made visible, which entail discriminatory attitudes and exclusionary practices leading to a struggling academic journey. Interestingly, women scholars have their agency in dealing with the challenges encountered.
Hybrid Source Laterally Diffused MOS Drain Engineering for ESD Robustness

The Hybrid source laterally diffused MOS (LDMOS) eliminates snapback of the LDMOS due to the parasitic bipolar junction transistor (BJT). The safe operating area (SOA) and power to failure are no longer limited by the parasitic BJT, but rather by the drain engineering of the device. The impact of drain engineering schemes on these metrics can be explored in the absence of BJT induced snapback. Under grounded gate, very fast transmission line pulse (vf-TLP) conditions, adopting an optimized stepped shallow trench isolation (STI) drain architecture increased the Hybrid source LDMOS power to failure by 68% without compromising the size of the device.
Clinical Decision Support Systems and Trust in Automation: Case of a Clinical Reminder for Titration of Beta Blockers

Trust in automation depends on more than just the automation itself, but the larger context in which the automation and the human operator are collaborating. This study takes a naturalistic approach to explore providers' trust in a Clinical Decision Support System. Primary Care Providers were shown simulated medical records and a prototype Clinical Reminder indicating that the patient should be titrated with recommended Beta Blockers to address the patient's Heart Failure with reduced ejection fraction. Analysis of responses showed three main themes: Concerns about the medical documentation used to generate the recommendation; Complexity of the patient condition and care delivery context (and how such factors limit possible courses of action); and Concerns about the Clinical Reminder and clinical guideline it is instantiating. These results align with the macrocognitive model of trust and reliance based on sensemaking and flexecution.
Research Progress of TCM Psychological Techniques in the Treatment of Clinical Depression

: With the improvement of social productivity, social pressure is generally increasing. Depression caused by social factors is increasing day by day. Although Western antidepressant drugs have achieved clinical efficacy, they often have large side effects, poor group tolerance, and high recurrence rate. At present, the TCM concept has achieved remarkable results in the treatment of mental diseases. This article will review the research of various TCM psychological techniques in the treatment of clinical depression.
Special Issue Guest Editorial: The Challenges of Experimental Designs in Entrepreneurship Education Research - An Interview With Thomas D. Cook

Research into entrepreneurship education is on the rise, yet the assessment of causality resulting from various teaching methods and their impacts on students and society at large remains limited. Consequently, incorporating experimental designs into entrepreneurship education research becomes imperative to move the field forward. Establishing cause-and-effect relationships, discerning which approaches yield desired outcomes (and which do not), contributes to a clearer understanding of the connections between educational activities and their results. This special issue underscores the importance of experiments as a methodological tool for showcasing causality. In this editorial, we expand on the reasons for the need for more experiments within the field. Additionally, we feature an interview with Dr. Thomas D. Cook, a pioneer in education research experiments, and offer an overview of the articles included in this special issue. We finish with a shortlist of tips for anyone interested in conducting experiments.
The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios

NOTICE: this is the author’s version of a work that was accepted for publication in FEBS Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in:
Mesure de risque : détection du régime de crise et calcul de la Value-at-Risk

This work aims to study the behavior of financial assets' returns and to measure market risk. Using the hidden Markov model, we classify the data according to the criteria of crisis by detecting the crisis en non-crisis regimes. By adopting the power laws to model the tail of the distribution and by taking into account this classification, we measure the Value-at-Risk (VaR) and we propose a new indicator for portfolio management.
Density‐driven current between reed belts and open water in a shallow lake

Differential heating of surface waters of lakes caused by shading from vegetation can induce convection, which could be significant for the ecosystem because the chemistry and biology can differ in the reed belt zone compared to the open lake. This process has been given little attention in the literature. In the present study surface currents just outside a reed belt as well as radiation and water temperature profiles within and outside the vegetated belt were measured in a shallow lake in southern Sweden to determine the lateral flux between the two zones. The measured surface current directed toward the vegetation was about 1 cm/s. Net radiation at the water surface was 85% lower within the vegetation than in the open lake. The water surface temperature during sunny days was on average 0.5°C warmer outside the reed belt, and at maximum 1°C warmer. The lateral heat flux from the open water into the water within the reeds was estimated to ∼200 W/m2 during midday on sunny days, which corresponded to a calculated maximum current of 1.5 cm/s. This current between the open water and the reed vegetation is presumably the main water exchange process between the two zones during sunny summer days with low wind speeds.
Analysis and Attack Detection in GSM Mobile Network With an Intelligent Jammer Using ANFIS Classifier

A Mobile Ad hoc Network (MANET) is an autonomous system comprising mobile nodes that self-organize and connect via wireless networks, without reliance on a predefined infrastructure. These nodes are inherently susceptible to jamming, a form of denial-of-service attack that renders mobile services unavailable in the affected area. In this work, we introduce an intelligent jammer, constructed based on the Received Signal Strength Index-based Transmission Power Control (RSSITPC) Algorithm. This algorithm leverages Received Signal-Strength Indicator (RSSI) data to ascertain the optimal transmission powers for neighboring nodes and dynamically adjust these powers. The design of the intelligent jammer system incorporates a circuit interface, power unit, power detector, and GSM scanner. It employs a DAC-centered RSSITPC Algorithm to differentiate the jamming signal from legitimate signals by comparing the voltage in the received signal. Following the design phase, a Jamming Attack (JA) analysis is conducted, utilizing metrics such as the Packet Send Ratio (PSR) and Packet Delivery Ratio (PDR). Subsequently, a Hybrid Cross-layer Rate Adaptation (CLRA) Scheme is implemented to enhance JA detection and improve Wireless Link Utilization. The Adaptive Neuro-Fuzzy Interference System (ANFIS) classifier is then used to categorize data as either attack or regular data. For regular data, the Control Channel Attack Prevention (CCAP) algorithm is applied as a preventive measure. The proposed system’s effectiveness is validated through comparative performance analysis with other widely used systems. Additionally, considerations are made for the adaptability of these methodologies to evolving intrusion techniques and changing network environments, as well as their scalability in larger, more complex networks.
The roles of T cells in psoriasis

Psoriasis is a recurring inflammatory skin condition characterized by scaly, red patches on the skin. It affects approximately 3% of the US population and is associated with histological changes such as epidermal hyperplasia, increased blood vessel proliferation, and infiltration of leukocytes into the skin’s dermis. T cells, which are classified into various subtypes, have been found to play significant roles in immune-mediated diseases, particularly psoriasis. This paper provides a review of the different T lymphocyte subtypes and their functions in psoriasis, as well as an overview of targeted therapies for treating psoriasis.
Nomenclature and correlation of the North American continental Tertiary

This report presents a provincial time scale for the North American continental Tertiary. It proposes a standardized terminology of purely temporal significance based on North American mammal-bearing units, of which the constituents are defined in terms of precisely analyzed faunas and the related stratigraphy. With such a nomenclature, exact information may now be conveyed without facing the continual dilemma between trying to conform to the European standard time scale or using American formation names as time units. The latter has been increasingly the practice in spite of inevitable ambiguities. In addition, it will be possible to discuss problems of relative age relationship and stratigraphic correlation without the distraction of endless controversies over epoch boundaries. More than 300 significant rock and faunal units are defined, located, and delimited and, if necessary, discussed in the glossary. They have been analyzed in accordance with the most recent data afforded by field research and work on collections by the various specialists. The correlation chart is in reality a graphic abstract, giving a bird’s-eye view of the North American continental Tertiary as it is known to date. Tentative correlations with the European scale are added. The bibliography is selected for convenience rather than completeness.
Uranium Deposits of the Mount Isa Region and Their Relationship to Deformation, Metamorphism, and Copper Deposition

The Mount Isa region contains over 20 uranium deposits, few of which contain economic concentrations of uranium. They are thought to be significant in the exploration for new copper deposits, based on the model that the uranium deposits are located in the pathways of oxidized hydrothermal fluids that formed the postmetamorphic Mount Isa copper orebodies. There are two uranium deposit types, both hosted in volcanosedimentary rocks. We suggest that they represent one mineralization event but different metamorphic histories. Examples in the eastern low-grade metamorphic zone are dominated by a brannerite-anatase-apatite assemblage and are low in uranium. The examples in the western high-grade metamorphic zone are characterized by uraninite and titanite with higher uranium concentrations. The chemical association of U, Ti, and Ca is consistent for all deposits; however, phosphate is only important at low metamorphic grade. The most likely mechanism of formation in the lower metamorphic grade Anderson’s Lode example is the complete replacement of chlorite in the sedimentary host-rock matrix by the mineralizing assemblage. In this model, chlorite acted as a reductant, allowing the deposition of uranium from an oxidized fluid. This mechanism of uranium deposition is similar to that proposed for unconformity-type uranium deposits. We conclude that these uranium deposits are metamorphosed equivalents of Proterozoic unconformity-type uranium deposits found elsewhere in northern Australia. At Anderson’s Lode, brannerite and apatite were concentrated in veinlets by pressure dissolution after the deposition of the original assemblage. These pressure dissolution seams are cut by premetamorphic quartz-chlorite veins. Examples at higher metamorphic grade have textures that suggest uranium deposition was pre- to synmetamorphic at the latest. This precludes any genetic or temporal connection between the uranium deposits and the postmetamorphic Mount Isa copper deposit.
Temporal and spatial patterns of foraging in two syntopic ant species, Manica yessensis and Formica lemani, on Mount Fuji, Japan

Spatiotemporal characteristics of terrestrial foraging were studied in two ant species, Manica yessensis and Formica lemani, in a volcanic desert on the southeast slope of Mount Fuji, Gotenba, Japan. Both ants are common in this habitat, and they construct underground nests in this dry area with sparse vegetation. Nests of M. yessensis have multiple nest‐openings on the surface, whereas nests of F. lemani have very few openings, but their nesting and foraging areas overlap completely. A “mark‐and‐observe” method applied to M. yessensis demonstrated that worker ants of this species move between openings more than 3 m away. A study plot (6 m × 12 m quadrat) was set up, in which all nest‐openings of both species were mapped. Day‐long observations on numbers of foragers in this plot revealed that foraging M. yessensis are active in morning and evening, while F. lemani continues foraging all day, but both species cease activity at night. Associations between locations of foragers and nest‐openings differed significantly between the two species, that is, surface foraging of M. yessensis workers was largely confined to the vicinity of their nest‐openings, whereas foragers of F. lemani travelled far from their nest‐openings. The function of multiple nest‐openings in M. yessensis is discussed.
Biostratigraphy, chemostratigraphy and thermal maturity of the A1-NC198 exploration well in the Kufra Basin, SE Libya

Abstract The A1-NC198 exploration well was drilled in the Kufra Basin in 2007 by RWE Dea and represented only the third well in a large, 400 000 km 2 frontier basin. Despite being dry and lacking any hydrocarbon shows, the well provides important data to improve the understanding of the regional petroleum play. In the 1980s and 1990s the basin9s prospectivity was questioned largely because of supposed (1) lack of structuration, (2) lack of source rock and (3) thermal immaturity at Silurian level. Following a series of academic and industry studies over the past 10 years, these assertions can no longer be upheld. The analysis of available seismic has proven the existence of Murzuq-style fault blocks as well as late Ordovician glacial erosional relict buried hills, potentially forming suitable structural and stratigraphic traps. The presence of hot shale in the Kufra Basin is evidenced by typical seismic onlaps of strong amplitude reflectors at base Silurian levels, shallow drilling results and outcrop spectral gamma-ray evidence. A spore colouration study of A1-NC198 cuttings indicates a deep oil window maturity for the Silurian, implying potential oil generation in the basin if suitable Silurian source rocks exist. The stratigraphy of the A1-NC198 succession was analysed by means of biostratigraphy and chemostratigraphy, which form the basis for improved well correlations within the basin.
The Relationship between the Presence of Cardiohepatic Syndrome and Mortality in Heart Failure with Reduced Ejection Fraction.

OBJECTIVE Heart failure (HF) is a major health burden that commonly affects liver function. Therefore, cardiohepatic syndrome (CHS) has been defined to describe the relationship between the heart and the liver. In this study, we aimed to evaluate the effect of CHS on long-term mortality in HF with reduced ejection fraction (HFrEF). METHODS Patients followed at the outpatient HF clinic of our hospital with HFrEF between 2010 and 2018 were retrospectively analyzed. CHS was defined as elevation of at least two of three cholestasis parameters (total bilirubin, alkaline phosphatase, and gamma-glutamyl transferase) above the upper limit of normal. Patients were divided into two groups according to the presence of CHS. The endpoint was all-cause mortality. Patients were followed up for a median of 4.4 (3.3-5.9) years. RESULTS A total of 469 patients were included in the study. The mean age of the group was 52.2 ± 11.9 years and 75.5% of the patients were males. About 22.4% (n = 105) of the patients had CHS. Patients with CHS were older and had more comorbidities than patients without CHS. Furthermore, significantly worse left and right ventricular functions were observed in CHS (+) group. All-cause mortality was significantly higher in CHS (+) group (61.9% vs. 19.5%, P < 0.001). Multivariate analysis revealed the presence of CHS (HR: 2.92, 95% CI: 2.09-4.07, P < 0.001) as an independent predictor of long-term mortality. CONCLUSION The presence of CHS is associated with increased long-term mortality in outpatients with HFrEF. As an easy parameter to assess from routine laboratory parameters, CHS should be used to evaluate the long-term prognosis of patients with HFrEF.