Miracle-dz/UniFAR-FTUs huggingface dataset:
ANALYSIS OF USE OF COLLOID NANOPARTICLES FOR MYOCARDIAL DELIVERY IN ULTRASOUND-TARGETED MICRO BUBBLE DESTRUCTION

: Introduction: Ultra sound (US) targeted micro bubble destruction (UTMD) is a encouraging method for delivering genetic material to the heart. The aim of this study was to test whether colloid nanoparticles can be delivered to the rat myocardium using UTMD and to determine whether tissue damage and contractile dysfunction occurs in hearts exposed to UTMD in vivo conditions. Material and Methods: This descriptive study was conducted in Rural Health Centre Mubarakpur, District Bahawalpur during January 2019 to July 2019. Hearts from anaesthetized rats were exposed to per ﬂuorocarbon-enhanced sonicated dextrose albumin (PESDA) (at two different micro bubble concentrations) and US at peak pressures of 0.6, 1.2, or 1.8 MPa for 1, 3, or 9 min. During US, pairs of 30 and 100 nm ﬂuorescent nano spheres were infused intravenously. Rats exposed to PESDA alone or US alone showed no functional abnormalities, no capillary ruptures, and no nanosphere delivery. Results: The data are expressed with the mean values and mean+1 standard error means (SEM). The differences in nano particulate delivery, premature ventricular contraction (PVCs), and vascular rupture between groups was assessed using a two way analysis of variance (ANOVA), examining the effect of two ﬁxed factors. Conclusion: UTMD allows for colloid nano particles to be delivered to the rat myocardium through micro vessel rupture sites. The efﬁciency of ultra sound
BIOINFORMATICS Improving HIV coreceptor usage prediction in the clinic using hints from next-generation sequencing data

Motivation: Due to the high mutation rate of human immunodeﬁciency virus (HIV), drug-resistant-variants emerge frequently. Therefore, researchers are constantly searching for new ways to attack the virus. One new class of anti-HIV drugs is the class of coreceptor antagonists that block cell entry by occupying a coreceptor on CD4 cells. This type of drug just has an effect on the subset of HIVs that use the inhibited coreceptor. A good prediction of whether the viral population inside a patient is susceptible to the treatment is hence very important for therapy decisions and pre-requisite to administering the respective drug. The ﬁrst prediction models were based on data from Sanger sequencing of the V3 loop of HIV. Recently, a method based on next-generation sequencing (NGS) data was introduced that predicts labels for each read separately and decides on the patient label through a percentage threshold for the resistant viral minority. Results: We model the prediction problem on the patient level taking the information of all reads from NGS data jointly into account. This enables us to improve prediction performance for NGS data, but we can also use the trained model to improve predictions based on Sanger sequencing data. Therefore, also laboratories without NGS capabilities can beneﬁt from the improvements. Furthermore, we show which amino acids at which position are important for prediction success, giving clues on how the interaction mechanism between the V3 loop and the particular coreceptors might be inﬂuenced. Availability: A webserver is available at
The BRIDGE HadCM3 family of climate models: Geoscientific

Understanding natural and anthropogenic observational datasets, we show that these models produce a good representation of many aspects of the climate system, including the land and sea surface temperatures, precipitation, ocean circulation, and vegetation. This evaluation, combined with the relatively fast computational speed (up to 1000 times faster than some CMIP6 models), motivates continued development and scientiﬁc use of the HadCM3B family of coupled climate models, predominantly for quantifying uncertainty and for long multi-millennial-scale simulations.
Materials & Molecular Research Division RHODAMINE-B ON THE ELECTRODEPOSITION OF ON COPPER

Rhodamine-B chloride (lO~M) has been used as a model substance of plating additives in a study of the electrodeposition of Pb from 1 M NaC104, 0.5 and 5 mM Pb++ (pH 3) on Cu. Ellipsometer measurements during - cyclic voltammetry have shown that the addition of dye results in a more com-, pact bulk deposit than obtained in its absence. It also prevents complete monolayer coverage during formation of the Pb underpotential deposit and shifts the bulk deposition peak to more cathodic potentials during the first potential cycle. Dye effects on potential and micromorphology disappear during subse quent cycling, but reappear after relaxation periods at open circuit. Depletion and readsorption of dye on the surface have been confirmed by spectroscopic ellipsometry. Different optical film models have been investigated for the interpretation of spectroscopic ellipsometer measurements by use of multidimensional analysis.
Use of a novel non-parametric version of DEPTH to identify genomic regions associated with prostate cancer risk

Background : We have developed a GWAS analysis method called DEPTH (DEPendency of association on the number of Top Hits) to identify genomic regions potentially associated with disease by considering overlapping groups of contiguous markers (e.g. single nucleotide polymorphisms, SNPs) across the genome. DEPTH is a machine learning algorithm for feature ranking of ultra-high dimensional datasets, built from well-established statistical tools such as bootstrapping, penalised regression and decision trees. Unlike marginal regression, which considers each SNP individually, the key idea behind DEPTH is to rank groups of SNPs in terms of their joint strength of association with the outcome. Our aim was to compare the performance of DEPTH with that of standard logistic regression analysis. Methods : We selected 1,854 prostate cancer cases and 1,894 controls from the UK for whom 541,129 SNPs were measured using the Illumina Infinium HumanHap550 array. Confirmation was sought using 4,152 cases and 2,874 controls, ascertained from the UK and Australia, for whom 211,155 SNPs were measured using the iCOGS Illumina Infinium array. Results : From the DEPTH analysis we identified 14 regions associated with prostate cancer risk that had been reported previously; five of which would not have been identified by conventional logistic regression. We also identified 112 novel putative susceptibility regions. Conclusions : DEPTH can reveal new risk-associated regions that would not have been identified using a conventional logistic regression analysis of individual SNPs. Impact : This study demonstrates that the DEPTH algorithm could identify additional genetic susceptibility regions that merit further investigation.
Pembelajaran Bahasa Indonesia Siswa di SMA Labschool Pembelajaran Bahasa Indonesia Siswa di SMA Labschool Jakarta Pembelajaran Bahasa Indonesia Siswa di SMA Labschool

materials, s learning at SMA Labschool Jakarta. This research uses a qualitative approach with a phenomenological method. Data collected through observation, interviews, and documentation. Data analysi describing, classifying, interpreting, and narrating data. The results showed: (a) the curriculum, which used the 2013 curriculum; (b) the purpose, which is to shape character, knowledge, skills and la material that emphasizes aspects of experience, knowledge, skills and language attitudes; (d) Strategy and Approach that is student centered learning with a scientific and communicative approach; (d) Media, Crystal Display cover the learning process and outcomes. Abstract: This study aims to gain an in-depth understanding of the curriculum, goals, materials, strategies, approaches, media, and evaluation of Indonesian language learning at SMA Labschool Jakarta. This research uses a qualitative approach with a phenomenological method. Data collected through observation, interviews, and documentation. Data analysis using Creswell's model, namely: organizing, reading, describing, classifying, interpreting, and narrating data. The results showed: (a) the curriculum, which used the 2013 curriculum; (b) the purpose, which is to shape character, knowledge, skills and language attitudes; (c) material, namely text material that emphasizes aspects of experience, knowledge, skills and language attitudes; (d) Strategy and Approach that is student centered learning with a scientific and communicative approach; (d) Media, i.e. paperback, laptop, and Crystal Display; and (e) Evaluation, which measures overall learning activities that cover the learning process and outcomes. depth understanding of the curriculum, goals, trategies, approaches, media, and evaluation of Indonesian language learning at SMA Labschool Jakarta. This research uses a qualitative approach with a phenomenological method. Data collected through observation, interviews, and s using Creswell's model, namely: organizing, reading, describing, classifying, interpreting, and narrating data. The results showed: (a) the curriculum, which used the 2013 curriculum; (b) the purpose, which is to shape nguage attitudes; (c) material, namely text-based material that emphasizes aspects of experience, knowledge, skills and language attitudes; (d) Strategy and Approach that is student centered learning with a i.e. paperback, laptop, and Liquid ; and (e) Evaluation, which measures overall learning activities that
CORRIGENDUM: Astrophysical and laboratory experiments and theories on high energy plasmas

The effort to produce plasmas that can approach the conditions where ignition by fusion reactions can take place has generated a series of new experiments and theories on high energy plasmas whose results are relevant to the understanding of important phenomena in astrophysics. In particular, magnetic reconnection processes that occur in collisionless regimes where the effects of finite electrical resistivity are no longer significant are observed in magnetically confined plasmas where the peak electron temperatures approach or exceed 10 keV. In addition, means have been devised to control the onset of reconnection, for instance by injecting or producing high energy particle populations in regions of the plasma column where the factor which drives reconnection-the pressure gradient-resides. The relationship of these results to space physics regimes such as those characteristic of the Solar Corona or of planetary magnetospheres is discussed. Another important process is that of the so-called anomalous viscosity: the rate of angular momentum transfer which is higher than that expected from the effects of (discrete) ion-ion collisions. To explain the observation of accretion on compact objects (e.g. Neutron stars or black holes) it is, in fact, necessary to assume an effective viscosity with a rather specific spatial profile. Toroidal laboratory experiments where plasma rotation is induced by the injection of energetic neutral beams show definite evidence of anomalous viscosity which theoretical models can explain. As for the spatial profile, the support laboratory experiments have provided to the so-called "Principle of Profile Consistency" of the electron temperature, that translates into a specific class of relevant transport coefficients, can be considered as a starting basis to deal with the problem of the viscosity characterizing accretion disks. Finally, the scattering of high energy particle populations produced within thermal plasmas by collective modes such as lower hybrid modes (in the so-called slide-away regime), magnetosonic and whistler modes (as observed in deuterium-tritium plasmas where 3.5 MeV alpha -particles are produced) and bursting processes associated, for instance, with the so-called "fishbone" modes are described. The applicability is pointed out to such diverse issues in space physics as the observation of ion-conics in the Earth's magnetosphere and the process by which the transverse energy level of electrons emitting synchrotron radiation are repopulated.
Feature Extraction and Classification for Segmentation of Overlapping Cervical Cells by Multiple Level Set Functions Optimization

: Feature Extraction and classification is an important task in medical applications. In medical examination of specimens the presence of blood reduces the accuracy and it leads to false results. In this work an algorithm for extraction of features is given by moment invariants. Using Legendre moment invariants seven moments are calculated and normalization is done using the central moments. The classification of the specimen to identify whether it is normal or abnormal is done with the help of Artificial Neural Networks. Pap smear test is usually done in the lower part of the cervix of humans.To find any unusual developments the specimen is viewed under the microscope to find any abnormal changes which leads to cancer. Proper examining of cell images reduces the deaths of cervical cancer. Feature extraction is by using Legendre Moment Invariants where moment’s upto seven are calculated. With the help of Artifical Neural Networks classification is done. Thetype of learning used is Supervised Learning.Segmentation of overlapping cells is done with the help of level set functions taking into account the unary and binary constraints. Instead of segmenting the cell as a whole, individual cells within the clumps are identified and segmented. In this manner the specimen examination and classification in medical diagnosis for the treatment of diseases is improved.
Applied Research Branch Strategic Policy Human Resources Development Canada Direction générale de la recherche appliquée Politique stratégique Développement des ressources humaines Canada

La série de documents de recherche comprend des études et des travaux de recherche réalisés sous l'égide de la Direction générale de la recherche appliquée, Politique stratégique (PS). Il s'agit notamment de recherches secondaires sous forme d'études de base et d'analyses documentaires qui appuient les efforts de recherche de PS. The Influence of Employee Involvement on Productivity: A Review of Research
and Predictors of the Trajectories of Self-Reported Attentional Fatigue in Women With Breast Cancer Undergoing Radiation Therapy

This study of breast cancer patients who underwent radiation therapy (RT) examined how attentional fatigue changed from the time of simulation to four months after the completion of RT and investigated whether specific variables predicted initial levels of attentional fatigue and characteristics of the trajectories of attentional fatigue. Seventy-three women completed a number of measures (i.e., Attentional Function Index, General Sleep Disturbance Scale, Center for Epidemiologic Studies-Depression scale, Spielberger State-Trait Anxiety Inventories, Brief Pain Inventory) over six months. Descriptive statistics and hierarchical linear modeling were used for data analysis. Large amounts of inter-individual variability were found in the trajectories of attentional fatigue. At baseline, higher levels of attentional fatigue were associated with younger age, not working, a higher number of comorbidities, and higher levels of trait anxiety. The trajectory of attentional fatigue improved over time for women with a higher body mass index at baseline. This study is the first to identify predictors of inter-individual variability in attentional fatigue in women with breast cancer undergoing RT. The various predictors should be considered in the design of future correlational and interventional studies in this population.
Barriers and Facilitators Related to Heart-healthy Lifestyle Among Persons with Acute Coronary Syndrome Syndrome, Bangladesh, Barriers, Facilitators, Heart-healthy Lifestyle., Smoking, Physical Exercise, Dietary Lifestyle, Qualitative Descriptive Study

A case-control study to Abstract: Leading a healthy lifestyle is one of the important ways of dealing with acute coronary syndrome. However, lifestyle information has been insufficiently documented in the literature in a context of Bangladesh. Thus, this study aimed to explore barriers and facilitators of heart-healthy lifestyle among persons with acute coronary syndrome in Bangladesh. This study used a qualitative descriptive method. Qualitative data were gathered via four focus group discussions that included 22 male participants with acute coronary syndrome, 18 of whom undertook in-depth interviews as did 11 family members. Content analysis process was used to analyze the data. Findings indicated that smoking cessation barriers were incapable of dealing with nicotine withdrawal symptoms; confronting stress and tension; and beliefs that smoking helps work productively. Physical activity barriers were constraints imposed by physical conditions; exercise not being a habit, lack of time, and lack of knowledge. Dietary barriers included facing hunger from lesser food amounts; conflict over food preferences; insufficient knowledge; insufficient support; and low income. Facilitators to modify heart-healthy lifestyle were commitment to follow advice; perceived benefits; perceived awareness; support; income adequacy; and basic education. The results provide understanding of the factors related to modify heart-healthy lifestyles among persons with acute coronary syndrome in Bangladesh. This evidence contributes to the development of useful interventional strategies in order to lifestyle modification which contribute to prevent complications of the disease and prolonging life. Pacific Rim Int J Nurs Res 2018; 22(3)
A CORRELATION STUDY ON COMMUNICATION PATTERN, FINANCIAL WELL BEING AND MONEY ATTITUDE OF MARRIED COUPLES

called as Statistical Research Design, it is an analysis of the past as opposed to the future. It facilitates in studying frequencies, averages and other statistical calculations. The research paper studies the signicant relationship between Communication Pattern & Financial Well Being, Money Attitude & Financial Well Being and Communication Pattern & Money Attitude of married couples at Coimbatore city. Incorporating descriptive research as the research design, the study used survey method sourcing primary data from 500 respondents (250 couples). Married couples in Coimbatore City were the population of the study and the period of the study was from June 2018 - Oct 2020. Regarding instrumentation, for Communication Pattern Questionnaire of Christensen and Heavey (1990) with 11 items and Money Attitude Questionnaire by Kent T. Yamauchi and Donald I. Templer (1982) with 29 were used. Due to the non availability of a comprehensive Indianised scale, the researcher constructed a scale for Financial Well Being. Correlation Analysis was conducted to test the null hypothesis and the results revealed that there is a signicant relationship between between Communication Pattern & Financial Well Being, Money Attitude & Financial Well Being and Communication Pattern & Money Attitude.
Education Costs As An Investment In Human Capital

— At the stage of post-industrial development of social production, human capital becomes the basis for the income of the majority of the population in the form of wages, and determines the standard of living in a region or country, which, in turn, reflects the level of development of productive forces and the nature of production relations. The fall in real incomes of the population observed in recent years is an objectively observed risk of violating the conditions of a decent life and free development of a person, guaranteed by Art. 7 of the Constitution of the Russian Federation [1]. At the same time, as the results of the study show, to a certain extent, there is a direct proportional relationship between the level of education, the level of income of the population in the form of wages and the quality of life in a post-industrial society, which determines the relevance of the topic of this study. This dependence weakens at the mesoscale of the economy, but retains its importance at the mini-and micro level, although it is limited by subjective factors associated with the instability of the labor market.
Flexibility of Noncompetitive Avidin-Biotin Immunoassay: Immunoassay of Lutropin Applied to Different Signal Detection Systems

the noncompetitive avidin-biotin immunoassay (NASA) of Iutropin (LH) for use with radiometric, fluorometnc, time-resolved fluorometric, and luminometric detection systems by changing the enzyme substrate or conjugating avidin with different labels. The corresponding methods were used to determine LH in 40 urine samples, and the results were compared with those obtained by an immunoenzymometric assay (IEMA), also based on the NABA principle. Scatter plots of the results showed a linear relation with high correlation coefficients (r = 0.972-0.983), and bias plots showed good agreement between the four comparison methods and the lENA. The results indicate that the effectiveness of the NABA of LH is independent of the signal detection system. This means good flexibility for the user in choice of instrument and signal detection system. Additional Keyphrues: replaced immunoassays in detection macromolecules.
Agrobacterium -mediated transformation of durum wheat ( Triticum turgidum L. var. durum cv Stewart) with improved efﬁciency

An efﬁcient Agrobacterium -mediated durum wheat transformation system has been developed for the production of 121 independent transgenic lines. This improved system used Agrobacterium strain AGL1 containing the superbinary pGreen/pSoup vector system and durum wheat cv Stewart as the recipient plant. Acetosyringone at 400 m M was added to both the inoculation and cultivation medium, and picloram at 10 mg l 2 1 and 2 mg l 2 1 was used in the cultivation and induction medium, respectively. Compared with 200 m M in the inoculation and cultivation media, the increased acetosyringone concentration led to signiﬁcantly higher GUS ( b -glucuronidase) transient expression and T-DNA delivery efﬁciency. However, no evident effects of acetosyringone concentration on regeneration frequency were observed. The higher acetosyringone concentration led to an improvement in average ﬁnal transformation efﬁciency from 4.7% to 6.3%. Furthermore, the concentration of picloram in the co-cultivation medium had signiﬁcant effects on callus induction and regeneration. Compared with 2 mg l 2 1 picloram in the co-cultivation medium, increasing the concentration to 10 mg l 2 1 picloram resulted in improved ﬁnal transformation frequency from 2.8% to 6.3%, with the highest frequency of 12.3% reached in one particular experiment, although statistical analysis showed that this difference in ﬁnal transformation efﬁciency had a low level of signiﬁcance. Stable integration of foreign genes, their expression, and inheritance were conﬁrmed by Southern blot analyses, GUS assay, and genetic analysis. Analysis of T 1 progeny showed that, of the 31 transgenic lines randomly selected, nearly one-third had a segregation ratio of 3:1, while the remainder had ratios typical of two or three independently segregating loci.