Miracle-dz/UniFAR-FTUs huggingface dataset:
THE IMPACT OF A LOCKOUT POLICY ON LEVELS OF ALCOHOL-RELATED INCIDENTS IN AND AROUND LICENSED PREMISES

Mr. Gavan Palk is a Lecturer at CARRS-Q. He has graduate and post-graduate qualifications in law and psychology. He is also currently a PhD scholar investigating policing and law enforcement initiatives to reduce alcohol related violence associated with late night trading clubs and bars. His areas of research interests include alcohol related crime, drink driving, substance misuse in Indigenous communities and countermeasures to reduce alcohol-related harms. 2 Dr Jeremy Davey is Associate Professor and Deputy Director of CARRS-Q. His areas of research interest includes workplace fleet safety programs, drug driving and substance use in the workplace. He is Chief Researcher on a number of fleet safety programs for government and industry. He currently holds a number of ARC and CRC research grants along with other government and industry funded research programs. His areas of research interests include fleet safety programs, drink and drug driving detection and corresponding rehabilitation programs. Abstract This paper reports on the impact of a lockout policy on levels of alcohol-related offences in and around licensed premises. The lockout policy prevents patrons from entering or re-entering late night trading licensed premises for a specific period prior to closure. A modified police activity log was utilised by all first response operational police to record their attendance at incidents in and around licensed premises. Chi-square analyses of the prevalence of incidents before and after implementation of the lockout policy demonstrated that the number of alcohol-related offences requiring police attention was significantly proportionally lower following the liquor trading changes. particularly those related to disturbances and sexual offences were significantly reduced following the introduction of the lockout policy. However, while offences related to property, stealing and assault experienced a reduced trend, these did not reach significance. In contrast, traffic offence rates were unchanged. The findings of the study provide supportive evidence that lockout initiatives have potential as a major crime prevention technique to reduce specific types of alcohol-related offences.
Magnetic Integration Into a Silicon Carbide Power Module for Current Balancing

Threshold-voltage mismatch among paralleled dies leads to unbalanced turn-on peak currents and switching energies, thus degrading reliability. A passive method employing inversely coupled inductors of tens of nH and drive-source resistors reduces current unbalance. An integrated design of the coupled inductors is required to facilitate their practical use in a power module. A layout to achieve inverse coupling, high coupling coefficient, and low voltage stress, magnetic materials suitable for operation at tens of MHz, and high current rating of tens of amperes with small magnetic core are challenging for its implementation. A module with integrated coupled inductors that achieve inverse coupling by utilizing the copper trace of the substrate and bond wires, size comparable to the silicon carbide die, coupling coefficient higher than 0.98, tens of nH operating at tens of MHz, and current rating of tens of amperes was designed, fabricated, and validated in this work. The coupled inductors with magnetic material of low-temperature cofired ceramics are compatible with existing packaging technology for module fabrication. Effectiveness on reducing transient-current mismatch at various input voltages, load currents, and gate resistances was verified by experiments. Compared with the baseline module resembling commercial modules, the module with integrated coupled inductors reduces current unbalance from 36% to 6.4% and turn-on energy difference from 28% to 2.6% while maintaining the same total switching energy and negligible change of voltage stress.
Cytokine Production in Response to Central SARM Is Required for Neuronal Injury and

Four of the ﬁve members of the Toll/IL-1R domain–containing adaptor family are required for signaling downstream of TLRs, promoting innate immune responses against different pathogens. However, the role of the ﬁfth member of this family, sterile a and Toll/IL-1R domain–containing 1 (SARM), is unclear. SARM is expressed primarily in the CNS where it is required for axonal death. Studies in Caenorhabditis elegans have also shown a role for SARM in innate immunity. To clarify the role of mammalian SARM in innate immunity, we infected SARM 2 / 2 mice with a number of bacterial and viral pathogens. SARM 2 / 2 mice show normal responses to Listeria monocytogenes , Mycobacterium tuberculosis , and inﬂuenza virus, but show dramatic protection from death after CNS infection with vesicular stomatitis virus. Protection correlates with reduced CNS injury and cytokine production by nonhematopoietic cells, suggesting that SARM is a positive regulator of cytokine production. Neurons and microglia are the predominant source of cytokines in vivo, supporting a role for SARM as a link between neuronal injury and innate immunity. The Journal of Immunology , 2013, 191: 000–000.
COMPARISON OF NEW DIRECTLY ACTING ANTIVIRALS WITH PEGINTERFERON IN COMBINATION WITH SOFOSBUVIR FOR THE TREATMENT OF CHRONIC HCV INFECTION IN CHRONIC KIDNEY PATIENTS BOTH PRE-DIALYSIS AND ON DIALYSIS

: The HCV infection has a unique association with chronic kidney disease (CKD). The study was conducted from 20 January 2018 to 20 January 2019. The patients from different hospitals of Lahore were included, in which men and women with age range of 18 to 80 years were present. The medication was administered as 400mg/100mg tables once daily for 12 weeks. The assessments were conducted at screening, baseline, weeks 2, 4, 8, and 12 for on treatment and weeks 4 and 12 after treatment. Out of 100 patients, 97 (97%) achieved SVR 12 after 12 weeks of treatment. Majority (80%) of the participants experienced adverse effects; however, these were mild or moderate in severity. The findings of present study recommend use of both types of medications used, that is, peginterferon with sofosbuvir and Declatasvir/Ledipasvir with sofosbuvir for HCV infected patients with CKD. These medications are well tolerated, effective and safe for treatment of 12 weeks. Comparison New Acting Antivirals In Combination With Sofosbuvir For The Treatment Of Chronic HCV Infection In Chronic Kidney Patients Pre-Dialysis And On Dialysis
User as Innovator in IT development process

—In this paper, the benefits of user participation in value creation in the information technology (IT) development process are discussed. The literature studies allow for the conclusion that user role is very important and new methods are developed to increase user participation. The research results indicate that the user participation, although requested, is limited, therefore in the paper some changes are suggested.
The Market Price of Credit Risk: An Empirical Analysis of Interest Rate Swap Spreads

This paper studies the market price of credit risk incorporated into one of the most important credit spreads in the financial markets: interestrate swap spreads. Our approach consists of jointly modeling the swap and Treasury term structures using a four-factor affine credit framework and estimating the parameters by maximum likelihood. We solve for the implied special financing rate for Treasury bonds and find that the liquidity component of on-the-run bond prices can be very significant. We show that most of the variation in swap spreads is driven by changes in the liquidity of Treasury bonds rather than changes in default risk. We find that there are positive credit premia in swap spreads on average. These premia, however, vary significantly over time and were negative for much of the 1990s. Since the hedge-fund crisis of 1998, credit premia have become positive and are currently at historical highs.
VEMPIC

The comprehensive visual modeling of fluid motion has historically been a challenging task, due in no small part to the difficulties inherent in geometries that are non-manifold, open, or thin. Modern geometric cut-cell mesh generators have been shown to produce, both robustly and quickly, workable volumetric elements in the presence of these problematic geometries, and the resulting volumetric representation would seem to offer an ideal infrastructure with which to perform fluid simulations. However, cut-cell mesh elements are general polyhedra that often contain holes and are non-convex; it is therefore difficult to construct the explicit function spaces required to employ standard functional discretizations, such as the Finite Element Method. The Virtual Element Method (VEM) has recently emerged as a functional discretization that successfully operates with complex polyhedral elements through a weak formulation of its function spaces. We present a novel cut-cell fluid simulation framework that exactly represents boundary geometry during the simulation. Our approach enables, for the first time, detailed fluid simulation with "in-the-wild" obstacles, including ones that contain non-manifold parts, self-intersections, and extremely thin features. Our key technical contribution is the generalization of the Particle-In-Cell fluid simulation methodology to arbitrary polyhedra using VEM. Coupled with a robust cut-cell generation scheme, this produces a fluid simulation algorithm that can operate on previously infeasible geometries without requiring any additional mesh modification or repair.
Digital Innovation Challenges.” In The Collaborative in Luxembourg: Digital Innovation Challenges

Digital innovation has become a most forwarded proposition of economic policies aiming for economic diversification and technological innovation. Moreover, it appears to be a feasible solution to the problem for Luxembourg that lacks the physical space to foster the development of an industrial sector that would require large areas. Also, diversifying from the well- established large steel industry complex is a plus. However, many obstacles can hinder the effective implementation of sharing economy principles in the digital world. This study underlines the most active industry sector, transportation, which adopts the sharing economy principles. Moreover, it provides the status of sharing economy by the figures showing participation and motivation of people living in the Grand Duchy of Luxembourg. This study also highlights its challenges and related issues in terms of citizen participation and sharing economy based on digital platforms.
Edinburgh Research Explorer Deep Clustering with Concrete K-Means

We address the problem of simultaneously learning a k -means clustering and deep feature representation from unlabelled data, which is of interest due to the potential for deep k -means to outperform traditional two-step feature extraction and shallow clustering strategies. We achieve this by developing a gradient estimator for the non-differentiable k -means objective via the Gumbel-Softmax reparameterisation trick. In contrast to previous attempts at deep clustering, our concrete k -means model can be optimised with respect to the canonical k -means objective and is easily trained end-to-end without resorting to time consuming alternating optimisation techniques. We demonstrate the efficacy of our method on standard clustering benchmarks.
Twitter User Personality Prediction [Analysing Personality of Users from Tweets]

This project report focuses on a novel concept of using social media data of a particular user to reﬂect the underlying personality. In particular, we have stressed on user tweets to gauge the personality trait among a predeﬁned list of personality types. The team has implemented an end to end Personality Prediction model in Python with all considerations involved in a typical Machine Learning pipeline. As such, the system can be used as a benchmark or an extension to build upon further complex models on other social media platforms.
iLeanDMAIC – A methodology for implementing the lean tools iLeanDMAIC – A methodology for implementing the lean tools

Organizations focus must reside in their constant desire for improvement in order to satisfy their clients as a result of high-quality products, thus maximizing their profits through a waste reduction in the flow production. Lean thinking allows organizations to identify and eliminate wastes within the organization. The use of lean tools is considered a simple, efficient and cost-effective solution to achieve productivity and profit. DMAIC (Define, Measure, Analyze, Improve, Control) is a problem-solving methodology that improves processes, allows defect reduction and reduction of process variability, allowing companies to continuously improve their efficiency and performance. In this work, a combined methodology iLeanDMAIC based on Lean Tools and DMAIC was developed, aiming to help organizations to easily and accurately solve their problems. It includes a case-study implementation on an organization of the sector of wood products. We were able to successfully validate this methodology and to show its efficacy in enhancing production. Results using iLeanDMAIC allowed a reduction time in changeover in the assembly machine (from 39 min to 17 min), presenting this a 44% gain on manufacture. iLeanDMAIC can help organizations thrive against their competitors, make their business more cost-effective and efficient. Abstract Organizations focus must reside in their constant desire for improvement in order to satisfy their clients as a result of high-quality products, thus maximizing their profits through a waste reduction in the flow production. Lean thinking allows organizations to identify and eliminate wastes within the organization. The use of lean tools is considered a simple, efficient and cost-effective solution to achieve productivity and profit. DMAIC (Define, Measure, Analyze, Improve, Control) is a problem-solving methodology that improves processes, allows defect reduction and reduction of process variability, allowing companies to continuously improve their efficiency and performance. In this work, a combined methodology iLeanDMAIC based on Lean Tools and DMAIC was developed, aiming to help organizations to easily and accurately solve their problems. It includes a case-study implementation on an organization of the sector of wood products. We were able to successfully validate this methodology and to show its efficacy in enhancing production. Results using iLeanDMAIC allowed a reduction time in changeover in the assembly machine (from 39 min to 17 min), presenting this a 44% gain on manufacture. iLeanDMAIC can help organizations thrive against their competitors, make their business more cost-effective and efficient.
The Mathematics of Subjective Probability

a progressive procedure, and of two conditional to of n conditional In our coherence-based approach, and suitable conditional random We of negation, by verifying De Morgan’s Laws. We also show that conjunction and disjunction satisfy the associative and commutative properties, and a monotonicity property. Then, we give some results on coherence of prevision assessments for some families of compounded conditionals; in particular we examine the Fréchet-Hoeffding bounds. Moreover, we study the reverse probabilistic inference from the conjunction C n + 1 of n + 1 conditional events to the family {C n , E n + 1 | H n + 1 } . We consider the relation with the notion of quasi-conjunction and we examine in detail the coherence of the prevision assessments related with the conjunction of three conditional events. Based on conjunction, we also give a characterization of p -consistency and of p-entailment, with applications to several inference rules in probabilistic nonmonotonic reasoning. Finally, we examine some non p-valid inference rules; then, we illustrate by an example two methods which allow to suitably modify non p-valid inference rules in order to get inferences which are p -valid.
KNOWLEDGE ASSESMENT OF DIABETES AND INCIDENCE OF HYPERTENSION IN TYPE 2 DIABETIC PATIENTS

Diabetes is a major and growing global health problem which affects more than 171 million people and the number is expected to rise up to 366 million by 2030. T2DM is a self-manageable disease. Diabetes is not a single disease. Rather, it is a heterogeneous set of syndromes represented by high blood glucose associate to a relative or absolute deficiency of insulin. Patients of type 2 diabetes mellitus (T2DM) are at higher risk of cardiovascular and other secondary complications if the disease is not controlled. Detecting and managing hypertension in patients with diabetes is one of the most effective things that can be done to prevent adverse events. The use of anti-diabetic agents is reserved for the treatment of patients with type 2 diabetes whose symptoms cannot be controlled with diet and exercise alone. In patients with type 2 diabetes, the prevalence of hypertension is higher than in non-diabetic subjects. The main aim of the study is to evaluate the awareness of knowledge, management and treatment of diabetes and incidence of hypertension in type 2 diabetic patients. A descriptive, cross-sectional study was performed in the diabetic patients of Bahawalpur. A structured closed ended questionnaire was designed to assess the knowledge about management, treatment and prevention of diabetes. Descriptive statistics (Frequency, Percentage, Mean and SD) and inferential statistics (Chi-square, Mann-Whitney U, Kruskal Wallis) were applied using Statistical Package for Social Sciences (SPSS) version 20.0. There are thousands of diabetic patients all over Pakistan but in the project our sample size is very less i.e. 112 patients_+ 20% hence a total of 135 patient’s data was collected on the prevalence basis of the disease. Respondents from urban area were 94 (69.6%) while those of rural area respondents were 40 (29.6%). Respondents were divided on the basis of their family history and 100 (74.1) had family history of disease while 35 (25.9%) respondents had no family history of diabetes. 47 (34.8%) respondents suffered from diabetes less than 5 years while 86 (63.7%) volunteers had disease greater than five years. male had more knowledge than the women with the mean rank of 69.60. the respondents with education of graduation or above have the highest mean rank of 77.55 while illiterates had the lowest mean rank of 51.78. These findings demonstrate that immediate need for diabetes awareness programmers in rural areas of Bahawalpur region and the attention of healthcare professionals, researchers and policy makers to take essential steps in reducing the prevalence of diabetes.
Cigarette Smoke-Induced Lung Endothelial and Alveolar Epithelial Injury Cigarette smoke causes lung vascular barrier dysfunction via oxidative stress-mediated inhibition of RhoA and focal adhesion kinase

Cigarette smoke causes lung vascular barrier dysfunction via oxidative stress-mediated inhibition of RhoA and focal adhesion kinase. Am J Physiol Lung Cell Mol Physiol 301: L847–L857, 2011. published October 7, 2011; smoke (CS) is a major cause of chronic lung and cardiovascular diseases. Recent studies indicate that tobacco use is also a risk factor for acute lung injury (ALI) associated with blunt trauma. Increased endothelial cell (EC) permeability is a hallmark of ALI. CS increases EC permeability in vitro and in vivo; however, the underlying mechanism is not well understood. In this study, we found that only 6 h ofexposure to CS impaired endothelial barrier function in vivo, an effect associated with increased oxidative stress in the lungs and attenuated by the antioxidant N -acetylcysteine (NAC). CS also exacerbated lipopolysaccharide (LPS)-induced increase in vascular permeability in vivo. Similar additive effects were also seen in cultured lung EC exposed to cigarette smoke extract (CSE) and LPS. We further demonstrated that CSE caused disruption of focal adhesion complexes (FAC), F-actin ﬁbers, and adherens junctions (AJ) and decreased activities of RhoA and focal adhesion kinase (FAK) in cultured lung EC. CSE-induced inhibition of RhoA and FAK, endothelial barrier dysfunction, and disassembly of FAC, F-actin, and AJ were prevented by NAC. In addition, the deleterious effects of CSE on FAC, F-actin ﬁbers, and AJ were blunted by overexpression of constitutively active RhoA and of FAK. Our data indicate that CS causes endothelial barrier dysfunction via oxidative stress-mediated inhibition of RhoA and FAK.
Detectionof a1-AntitrypsinZ and S Mutationsby PolymeraseChain Reaction-MediatedSite-DirectedMutagenesis

a1-Antitrypsin (A1AT) deficiencyis a relativelycommon autosomal recessive disease, resuftingmost often from a singlebase paIr (1 bp)substitutioncalled the Z mutation. Previousgenetictestsfor carriers and affected patients have relied on quantitative binding of radioactive probes to an amplified gene product, because the mutation does not occur within a restriction enzyme site. Using polymerase chain reaction (PCR)-mediated site-directed mutagenesis, one can introduce a base substitution near the mutationsite,suchthatan inexpensiverestrictionenzyme (Taq I) can be used to differentiatenormal subjects, carriers, and affected patients. We have applied this method to the detection of the Z mutation and the S mutation, which In heterozygotes with a Z allele may lead to the development of symptoms similar to those in ZZ homozygous subjects.
Septic Patients Bene ted from Positive Microbial Culture in Mortality: A Propensity Score Matching (PSM) of the Chinese Epidemiological Study of Sepsis (CHESS) Study

Wei Chang Jiangsu Provincial Key Laboratory of Critical Care Medicine,Department of Critical Care Medicine, Zhongda Hospital, Southeast University Jianfeng Xie Southeast University Zhongda Hospital Qin Sun Southeast University Zhongda Hospital Fei Peng Southeast University Zhongda Hospital Qing Li Southeast University Zhongda Hospital Ming Xue Southeast University Zhongda Hospital Yuan Zhao Southeast University Zhongda Hospital Haibo Qiu Southeast University Zhongda Hospital Yi Yang (  yiyiyang2004@163.com ) Nanjing Zhongda Hospital, Southeast University https://orcid.org/0000-0003-1661-3568
a including phenotype with abnormal anchoring and

Mutations in PLOD3, encoding lysyl hydroxylase 3, cause a complex connective tissue disorder including recessive dystrophic epidermolysis bullosa-like blistering phenotype with abnormal anchoring fibrils and type VII collagen deficiency. Matbio (2018), Abstract Epidermolysis bullosa (EB), the paradigm of heritable skin fragility disorders, is associated with mutations in as many as 20 distinct genes. One of the clinical variants, recessive dystrophic EB (RDEB), demonstrates sub-lamina densa blistering accompanied by alterations in anchoring fibrils due to mutations in COL7A1 . In this study, we characterized a patient with widespread connective tissue abnormalities including skin blistering similar to that in RDEB. Whole exome sequencing, combined with genome-wide homozygosity mapping, identified a homozygous missense mutation in PLOD3 encoding lysyl hydroxylase 3 (LH3). No mutations in COL7A1 , the gene previously associated with RDEB, were detected. The level of LH3 was dramatically reduced in the skin and fibroblast cultures from the patient. The blistering in the skin occurred below the lamina densa and was associated with variable density and morphology of anchoring fibrils. The level of type VII collagen expression in the skin was markedly reduced. Analysis of hydroxylysine and its glycosylated derivatives (galactosyl-hydroxylysine and glucosyl-galactosyl-hydroxylysine) revealed marked reduction in glycosylated hydroxylysine. Collectively, these findings indicate that PLOD3 mutations can result in a dystrophic EB-like phenotype in the spectrum of connective tissue disorders and add it to the list of candidate genes associated with skin fragility. colored in yellow. Ferrous iron molecules are shown as brown spheres, and 2-oxoglutarate as black CPK representation. (e and Western blotting revealed markedly reduced LH3 protein levels in fibroblasts cultured from the skin of