Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of the Predictors of the Quality of Life in the Postpartum Period: A Cross-Sectional Study

Background: It is necessary to study the predictors of life quality in the early postpartum period. Early diagnosis, timely care and intervention can improve the health of mother and baby. We aimed to evaluate the predictors of the quality of life in the postpartum period. Methods: This cross-sectional study was conducted on 407 eligible women aged 18 to 47 yr, in the postpartum period, selected from clinics affiliated with Shahid Beheshti University of Medical Sciences, Tehran, Tehran, Iran in 2018. Data were collected using a demographic and obstetric questionnaire and Maternal Postpartum Quality of Life (MAPP-QOL) with Cronbach’s alpha coefficients of 0.96 to assess personal details and postpartum quality of life. Data analyzed using SPSS. Linear regression analysis was performed to examine the relationship between maternal predictors and quality of life in the postpartum period. Results: The postpartum quality of life had a significant relationship with income status (P<0.001), Number of Children (P=0.031), mother’s education(P=0.009) and maternal complications (P<0.001). Conclusion: This study confirmed the relationship between maternal predictors and the postpartum quality of life. It could facilitate clinicians and educators to improve the quality of life for postpartum women.
Stable CsPbBr3 Nanocrystals—Decorated Nanoporous Gold for Optoelectronic Applications

Halide perovskite colloidal nanocrystals have recently gained much attention thanks to their superior stability compared with their bulk counterpart and to their unique optical properties. In this paper, two systems combining nanocrystals and nanoporous gold are studied to create an optimal metal semiconductor heterojunction that can be used in photocatalysis and photovoltaic devices. The perovskite degradation phenomenon is observed when the nanoporous gold powder is mixed into the hexane suspension of nanocrystals, while the charge separation efficiency is increased by synthesizing the nanocrystals directly onto the gold porous structure. The analysis of the structural and optical properties evidences an energy transfer efficiency of 47%, along with the high structural stability of the hybrid system.
Sero-Epidemiological Study of Human Hydatidosis in Semnan and Sorkheh, Semnan Province, Iran

Background: To determine the seroprevalence of human cystic echinococcosis/hydatidosis which is one of the most important zoonotic diseases by ELISA using native antigen B in Semnan and Sorkheh, Semnan province, Iran, where no significant information about human infection exists. Methods: Overall, 957 human serum samples were randomly prepared from Semnan, Sorkheh, and its 13 surrounding villages in different seasons from 2017 to 2018. Antigen B was prepared from native hydatid cyst fluid of domestic sheep. All serum samples were evaluated by ELISA while the suspected cases were rechecked. The cut-off was calculated as the X ¯ ±2SD. Results: Overall, 48(5%) out of 957 (422 males and 535 females) were positive for hydatidosis. The seropositivity based on sex showed 20(2.1%) out of 422 in males and 28(2.9%) out of 535 in females. The distribution of seropositive samples based on residence area showed 41 (4.3) out of 882 in urban and 7 (0.7) out of 75 in rural areas. The highest seroprevalence cases was among housewives (2.1%) followed by employers (1.5%). Based on education, source of drinking water, and age groups the highest seropositivity was observed in high school and less, in the plumping water consumers, and 50 to 59 yr old age group, respectively. There was a significant difference between seropositivity with occupation, literacy, and age group (P<0.05). Semnan with 4% seropositivity had the highest prevalence followed by Sorkheh, county. Conclusion: High prevalence of the disease in this area emphasizes the importance of increasing people’s awareness about hydatidosis.
The influence of powdery mildew on chlorophyll a fluorescence and stomatal characteristics of pedunculate oak (Quercus robur L.)

Oak powdery mildew (Erysiphe alphitoides (Griffon and Maubl.) U. Braun and S. Takam. )) is one of the most common foliar pathogenic organism of oaks, exploiting harmful effects, particularly on young seedlings. To assess and evaluate these negative effects, an experiment was conducted under semi-controlled conditions with 20 one-year-old seedlings of Quercus robur L. infected with E. alphitoides, half of them showing 50% of leaf coverage by epiphytic mycelia and the other half a coverage of 75%. The results of the present study have shown that all observed parameters of chlorophyll a fluorescence transient were highly effective in the detection of severe biotic stress. Moreover, the studied parameters of slow fluorescence kinetics were also considerably influenced, with the coefficient of non-photochemical fluorescence quenching and the Stem-Volmer type non-photochemical fluorescence quenching parameters showing the fastest responses. In case of leaf stomatal traits, the decrease of stomata guard cell width coupled with the increase of stomatal density was observed as the protective mechanism of Q. robur against the stressor. The overall results showed the adverse effects of powdery mildew infection on the photosynthesis of pedunculate oak seedlings, which progressed in time and depended on the severity of the infection. The importance of the results of the present study lays in evaluation and monitoring of the effects of powdery mildew development on the photosynthetic apparatus of one-year-old Q. robur seedlings, which is the most vulnerable stage for the infection by the mentioned pathogen.
Network Intrusion Detection using MRF Technique

With the advent of the internet, cyber-attacks are changing rapidly and the security situation on the internet is not always optimistic. Machine Learning (ML) and In-depth Learning (DL) methods for community-based access to entry and present a quick teaching definition of the entire ML/DL method. Representative papers all the way have been listed, read, and summarized primarily based on their temporary or thermal interactions. Because information is critical to ML/DL strategies, it describes the amount of commonly used public databases used in ML/DL, discusses the complexities of using ML/DL for Internet protection and provides guidelines for course guides. KDD a set of information is a symbol of standing that is widely recognized within the study of the Acquisition strategies. A lot of work is underway to develop innocent identification strategies as information courses used to read and test the diagnostic version are equally problematic because high-quality information can improve offline access. This paper provides a KDD knowledge test set by recognizing the 4 Basic Courses, Content, Traffic and Handling in which all information attributes can be categorized using the Modified Random Forest (MRF). The test was completed by identifying the remaining 2 metric metrics, Visual Rate (DR) and False Noise Scale (FAR) of the Intervention Detection System (IDS). As a result of this evidence-based evaluation of the data set, the contribution of all 4 character studies in DR and FAR has been proven to help determine the validity of the information set.
Assessing the Validity and Reliability of the Dimensional Anhedonia Rating Scale (DARS) for the Iranian Population

Background: Dimensional Anhedonia Rating Scale (DARS) is the best questionnaire for assessing anhedonia, but it is unavailable for the Iranian population. Anhedonia is common in ordinary people but is often neglected, leading to major depression. Objectives: This study examined the psychometric properties of (DARS) in the Iranian population. Methods: This psychometric study was conducted on a sample of 474 general Iranian population in 2020 using the convenience sampling method. The participants completed the DARS and Beck Depression Inventory (BDI-II). The Pearson correlation coefficient was also used to determine convergent validity between DARS and BDI-II. Data were analyzed using SPSS software version 24. Results: Cronbach’s alpha (internal consistency) for the total score was 0.84. The relationship between DARS and depression (r = -0.37; P < 0.01) showed relevant convergent validity. The test-retest reliability coefficient (3-week interval) equaled 0.77. Exploratory factor analysis with a varimax rotation showed four factors. These four factors explained 0.64 of the total variance. Confirmatory factor analysis showed a good fitness for the 4-factor model construct. Conclusions: DARS is useful in assessing anhedonia in the normal population. According to the results, this scale has acceptable validity and reliability in the Iranian population and can be implemented in therapeutic interventions and research.
Effect of Different Glucose Monitoring Methods on Bold Glucose Control: A Systematic Review and Meta-Analysis

Objective To evaluate the effectiveness of different glucose monitoring methods on blood glucose control and the incidence of adverse events among patients with type 1 diabetes mellitus. Methods Using the method of literature review, the databases PubMed, Cochrane, and Embase were retrieved to obtain relevant research literature, and the selected studies were analyzed and evaluated. This study used Cochrane software RevMan5.4 to statistically analyze all the data. Results A total of 15 studies were included in this study, including 10 randomized controlled trials and 5 crossover design trials, with a total of 2071 patients. Meta-analysis results showed that continuous blood glucose monitoring (CGM) could significantly reduce the HbA1c level of patients, weighted mean difference (WMD) = −2.69, 95% confidence interval (CI) (-4.25, -1.14), and P < 0.001 compared with self-monitoring of blood glucose (SMBG). Meanwhile, the incidence of severe hypoglycemia in the CGM group was significantly decreased, risk ratio (RR) = 0.52, 95% CI 0.35-0.77, and P = 0.001. However, there was no statistical difference in the probability of diabetic ketoacidosis between CGM and SMBG groups, RR = 1.34, 95% CI 0.57-3.15, and P = 0.5. Conclusion Continuous blood glucose monitoring is associated with lower blood glucose levels than the traditional blood glucose self-test method.
Self-Declared Physical Activity Levels and Self-Reported Physical Fitness in a Sample of Italian Adolescents during the COVID-19 Pandemic

Only 20% of children worldwide reach the suggested physical activity (PA) levels, and the COVID-19 restrictions seemed to have worsened this situation. In addition, physical fitness (PF) is a crucial marker of health and combined with PA could predict future health status. The aim of this study was to compare reported PA and PF levels in a sample of Italian adolescents. We administered the International PA Questionnaire and International Fitness Enjoyment Scale to 208 adolescents aged 16.0 ± 1.5 (N = 166 females, 16 ± 2.0 years) recruited from a high school in the province of Milan (Italy). The majority of the subjects were “Minimally active” but reported adequate PF levels. In particular, subjects who reported a “Very good” PF perception, had a lower PA level. The misperception of reported PA and PF from our sample could reduce the future PA level in adolescents and lead to a negative spiral of disengagement in PA. These findings should lead to more attention on and improvements to PA promotion in the adolescent population after the restrictions caused by the COVID-19 pandemic.
Evaluasi Dampak Program Pelatihan Desain Grafis BLK Komunitas As Syifa Syech Yusuf di Kota Depok Terhadap Alumni Peserta 2019-2020

Dalam rangka menyiapkan ketersediaan sumberdaya manusia yang berdaya saing dan siap kerja dari kalangan pesantren untuk memenuhi kebutuhan tenaga kerja, Kementerian Ketenagakerjaan memberikan ruang kepada komunitas di Lembaga Pendidikan Keagamaan dan/atau Lembaga Keagamaan Non Pemerintah untuk bersinergi dalam program-program yang terkait dengan pelatihan kerja. Penelitian ini bertujuan mengukur indikator impact (dampak) dan menganalisis faktor-faktor yang memengaruhi pencapaian impact Program Pelatihan Desain Grafis di BLK Komunitas As Syifa Kota Depok berdasarkan aspek input, activities dan outcome. Teknik penarikan sampel menggunakan stratified random sampling sebanyak 84 sampel terhadap populasi 112 orang. Penelitian ini merupakan penelitian evaluasi sumatif dengan pendekatan kuantitatif. Analisis data pada penelitian ini adalah analisis deskriptif univariat dan bivariat, dengan keseluruhan pengolahan data menggunakan alat bantu SPSS. Analisis bivariat dilakukan menggunakan cross tabulation dengan uji Chi-square (? 2) dan Kendall’s Tau. Hasil penelitian menunjukkan capaian indikator dampak yakni: 1) alumni yang bekerja sebanyak 25 orang (49%); dan 2) alumni yang berwirausaha sebanyak 5 orang (9.8%). Sisanya merupakan responden dengan status belum bekerja oleh karena meneruskan pendidikan sebanyak 10 orang (19.6%) dan atau sedang mencari pekerjaan sebanyak 11 orang (21.6%). Indikator pada variabel outcome yang mempengaruhi dampak program pelatihan desain grafis di BLKK As Syifa adalah indikator Soft skill serta indikator Pengetahuan peluang usaha/kerja bidang desain grafis.
Alagille Syndrome in an Infant: A Rare Case Report

Alagille syndrome is a rare autosomal dominant disorder that affects multiple organs and systems including liver, heart, bones, vascular system, and kidneys and also causes facial abnormalities. Majority of the cases involve mutation in one copy of the JAG1 gene while rarely some patients may have mutations in NOTCH2 gene. There is substantial variation in the extent of symptomatology with which patients may present. However, mostly patients present in infancy with symptoms concerning liver like jaundice, pruritus due to cholestasis, vitamin A, D, E and K deficiencies. Additional symptoms include specific triangular facies, back pain due vertebras involvement and kidney failure. Diagnosis is generally made up on the basis of clinical manifestations, genetic studies and liver biopsy. Additional laboratory tests concerning the affecting organs like liver function tests etc. may further aid up in the diagnosis. There is no specific treatment and may require symptomatic treatment with multiple disciplinary approach. A 7 months old boy is presented as a case of Alagille syndrome with its typical features.
Edinburgh Research Explorer Identification of the Core Promoter and Variants Regulating Chicken CCKAR Expression

: Decreased expression of chicken cholecystokinin A receptor ( CCKAR ) attenuates satiety, which contributes to increased food intake and growth for modern broilers. The study aims to deﬁne the core promoter of CCKAR , and to identify variants associated with expression activity. A 21 kb region around the CCKAR was re-sequenced to detect sequence variants. A series of 5 (cid:48) -deleted promoter plasmids were constructed to deﬁne the core promoter of CCKAR . The effects of sequence variants located in promoter (PSNP) and conserved (CSNP) regions on promoter activity were analyzed by comparing luciferase activity between haplotypes. A total of 182 variants were found in the 21 kb region. There were no large structural variants around CCKAR . pNL − 328/+183, the one with the shortest insertion, showed the highest activity among the six promoter constructs, implying that the key cis elements regulating CCKAR expression are mainly distributed 328 bp upstream. We detected signiﬁcant activity differences between high-and low-growth associated haplotypes in four of the six promoter constructs. The high-growth haplotypes of constructs pNL − 1646/+183, pNL − 799/+183 and pNL − 528/+183 showed lower activities than the low-growth haplotypes, which is consistent with decreased expression of CCKAR in high-growth chickens. Lower expression of the high-growth allele was also detected for the CSNP5-containing construct. The data suggest that the core promoter of CCKAR is located the 328 bp region upstream from the transcription start site. Lower expression activities shown by the high-growth haplotypes in the reporter assay suggest that CSNP5 and variants located between 328 bp and 1646 bp upstream form a promising molecular basis for decreased expression of CCKAR and increased growth in chickens.
Pregnancy in Pulmonary Arterial Hypertension: A Multidisciplinary Approach

Pulmonary arterial hypertension (PAH), a female predominant disease, carries a high maternal and fetal mortality in pregnancy despite improved insight and the development of novel therapies. The high risk is attributed to the adaptive changes that take place to promote healthy fetal development during pregnancy, which can adversely affect the already compromised right ventricle in patients with PAH. While in the prior era emphasis was placed on termination of pregnancy, here we will illustrate through a multidisciplinary approach and meticulous planning at an expert center, these high-risk women can undergo successful childbirth.
Multi-Target Effects of ß-Caryophyllene and Carnosic Acid at the Crossroads of Mitochondrial Dysfunction and Neurodegeneration: From Oxidative Stress to Microglia-Mediated Neuroinflammation

Inflammation and oxidative stress are interlinked and interdependent processes involved in many chronic diseases, including neurodegeneration, diabetes, cardiovascular diseases, and cancer. Therefore, targeting inflammatory pathways may represent a potential therapeutic strategy. Emerging evidence indicates that many phytochemicals extracted from edible plants have the potential to ameliorate the disease phenotypes. In this scenario, ß-caryophyllene (BCP), a bicyclic sesquiterpene, and carnosic acid (CA), an ortho-diphenolic diterpene, were demonstrated to exhibit anti-inflammatory, and antioxidant activities, as well as neuroprotective and mitoprotective effects in different in vitro and in vivo models. BCP essentially promotes its effects by acting as a selective agonist and allosteric modulator of cannabinoid type-2 receptor (CB2R). CA is a pro-electrophilic compound that, in response to oxidation, is converted to its electrophilic form. This can interact and activate the Keap1/Nrf2/ARE transcription pathway, triggering the synthesis of endogenous antioxidant “phase 2” enzymes. However, given the nature of its chemical structure, CA also exhibits direct antioxidant effects. BCP and CA can readily cross the BBB and accumulate in brain regions, giving rise to neuroprotective effects by preventing mitochondrial dysfunction and inhibiting activated microglia, substantially through the activation of pro-survival signalling pathways, including regulation of apoptosis and autophagy, and molecular mechanisms related to mitochondrial quality control. Findings from different in vitro/in vivo experimental models of Parkinson’s disease and Alzheimer’s disease reported the beneficial effects of both compounds, suggesting that their use in treatments may be a promising strategy in the management of neurodegenerative diseases aimed at maintaining mitochondrial homeostasis and ameliorating glia-mediated neuroinflammation.
Ocrelizumab in Patients with Active Primary Progressive Multiple Sclerosis: Clinical Outcomes and Immune Markers of Treatment Response

Ocrelizumab is a B-cell-depleting monoclonal antibody approved for the treatment of relapsing-remitting multiple sclerosis (RRMS) and active primary progressive MS (aPPMS). This prospective, uncontrolled, open-label, observational study aimed to assess the efficacy of ocrelizumab in patients with aPPMS and to dissect the clinical, radiological and laboratory attributes of treatment response. In total, 22 patients with aPPMS followed for 24 months were included. The primary efficacy outcome was the proportion of patients with optimal response at 24 months, defined as patients free of relapses, free of confirmed disability accumulation (CDA) and free of T1 Gd-enhancing lesions and new/enlarging T2 lesions on the brain and cervical MRI. In total, 14 (63.6%) patients and 13 patients (59.1%) were classified as responders at 12 and 24 months, respectively. Time exhibited a significant effect on mean absolute and normalized gray matter cerebellar volume (F = 4.342, p = 0.23 and F = 4.279, p = 0.024, respectively). Responders at 24 months exhibited reduced peripheral blood ((%) of CD19+ cells) plasmablasts compared to non-responders at the 6-month point estimate (7.69 ± 4.4 vs. 22.66 ± 7.19, respectively, p = 0.043). Response to ocrelizumab was linked to lower total and gray matter cerebellar volume loss over time. Reduced plasmablast depletion was linked for the first time to sub-optimal response to ocrelizumab in aPPMS.
Development of novel paracetamol/naproxen co-crystals with an improvement in naproxen solubility.

Co-crystals are new solid forms of drugs that could resolve more than one problem associated with drugs formulations like solubility, stability, bioavailability, mechanical and tableting properties. A preliminary theoretical study for estimating the possible bonding between the co-crystal components (paracetamol and naproxen) was performed using the ChemOffice program. The results revealed a high possibility for bonding between paracetamol and naproxen and indicated the ability of molecular mechanics study to predict the co-crystal design. In this work, four different methods were used for the preparation of three different ratios 1:1, 2:1, and 1:2 of paracetamol:naproxen co-crystals. The four methods are liquid-assisted grinding, solvent evaporation method, ultrasonic-assisted co-crystallization, and microwave-assisted co-crystallization. The characterization of the prepared co-crystal was performed by Fourier transform infrared spectroscopy, Thermogravimetric Analysis, Differential scanning calorimetry, Powder X-Ray diffraction, and Field emission scanning electron microscopy. The results showed that the most successful method for co-crystal production was solvent evaporation methods. The FTIR and DSC results indicated the formation of paracetamol-naproxen co-crystals when prepared by using the solvent evaporation method in the three ratios 1:1 (N1), 2:1 (N2), and 1:2 (N3). Moreover, the PXRD results confirm the previous conclusions. A solubility study was conducted to compare the water solubility of pure paracetamol and naproxen with co-crystals solubility. The naproxen solubility was improved by more than two times in (1:1) and (1:2) paracetamol/naproxen co-crystals. To conclude, this work succeeded in formation of new paracetamol/naproxen co-crystals, which can be considered as a new promising technique for formulation of these two drugs with an obvious enhancement in naproxen solubility and crystallinity. This could be exploited in preparation of tablets with possible enhancement in dissolution and bioavailability, however, further work is needed to prove this assumption.
Assessing International Product Design And Development Graduate Courses: The mIT-Portugal Program

The Product Design and Development (PDD) course is part of the graduate curriculum in the Engineering Design and Advanced Manufacturing (EDAM) study in the MIT-Portugal Program. The research participants included about 110 students from MIT, EDAM, and two universities in Portugal, Instituto Superior Tecnico—Universidade Tecnica de Lisboa (IST) and the Universidade do Porto (FEUP). We investigated the PDD EDAM course in the context of the two other groups who studied a similar course in a different setting. Research tools included questionnaires, with questions related to students’ learning outcomes and perceptions as well as focus groups with EDAM faculty and students. We assessed the EDAM course format of several concentrated two-week long periods compared with a regular semester based on students and faculty feedback. In a question related to the product life cycle stages the MIT and EDAM students listed on average a higher number of items than that of the IST and FEUP students, indicating a higher level of learning. The learning approach that follows the MIT PDD course has been instrumental in successfully incorporating hands-on activities and student-faculty interactions into the EDAM program.