Miracle-dz/UniFAR-FTUs huggingface dataset:
Children : a Population-Based Study

Oral Health-Related Quality of Life (OHRQoL) of children and their families. A population-based cross-sectional study was carried out in Belo Horizonte, MG, Brazil. A representative sample of 1069 male and female preschoolers aged 60 to 71 months was randomly selected from public and private preschools and daycare centers. Data were collected using the B-ECOHIS. In addition, a questionnaire addressing socioeconomic and demographic data was self-administered by the parents/guardians. The criteria used to diagnose malocclusion were based on Foster and Hamilton (1969), Graboswki et al. (2007) and Oliveira et al. (2008). Descriptive, univariate and multiple Poison logistic regression analyses were carried out. The prevalence of malocclusion was observed in 46.2% of the children and deep overbite was the most prevalent type of malocclusion (19.7%), followed by posterior crossbite (13.1%), accentuated overjet (10.5%), anterior open bite (7.9%) and anterior crossbite (6.7%). The impact of malocclusion on OHRQoL was 32.7% among the children and 27.1% among the families. In Poisson multiple regression model adjusted for socioeconomic status, no significant association was found between malocclusion and OHRQoL of the children (PR=1.09, 95% CI: 0.96-1.24) and their families (PR=1.11, 95% CI: 0.94-1.31). It is concluded that children with malocclusion in this sample did not have a negative impact on their OHRQoL and of their families. Impact of Malocclusion on Oral Health-Related Quality of Life a m o n g B r a z i l i a n P r e s c h o o l Children: a Population-Based Study
The Sanitation Hygiene Infant Nutrition Ef fi cacy ( SHINE ) Trial : Rationale , Design , and Methods

Zvitambo Institute for Maternal and Child Health Research, and Ministry of Health and Child Care, Harare, Zimbabwe; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Queen Mary University of London, United Kingdom; Cornell University, Ithaca, New York; University of British Columbia, Vancouver, Canada; University of Michigan, Ann Arbor; Middlebury College, Vermont; George Washington University, Washington D.C.
Inhaled therapies in patients with moderate COPD in clinical practice: current thinking

: COPD is a complex, heterogeneous condition. Even in the early clinical stages, COPD carries a significant burden, with breathlessness frequently leading to a reduction in exercise capacity and changes that correlate with long-term patient outcomes and mortality. Implementation of an effective management strategy is required to reduce symptoms, preserve lung function, quality of life, and exercise capacity, and prevent exacerbations. However, current clinical practice frequently differs from published guidelines on the management of COPD. This review focuses on the current scientific evidence and expert opinion on the management of moderate COPD: the symptoms arising from moderate airflow obstruction and the burden these symptoms impose, how physical activity can improve disease outcomes, the benefits of dual bronchodilation in COPD, and the limited evidence for the benefits of inhaled corticosteroids in this disease. We emphasize the importance of maximizing bronchodilation in COPD with inhaled dual-bronchodilator treatment, enhancing patient-related outcomes, and enabling the withdrawal of inhaled corticosteroids in COPD in well-defined patient groups.
Screening and identification of MicroRNAs expressed in perirenal adipose tissue during rabbit growth

MiRNAs regulate adipose tissue development, which are closely related to subcutaneous and intramuscular fat deposition and adipocyte differentiation. As an important economic and agricultural animal, rabbits have low adipose tissue deposition and are an ideal model to study adipose regulation. However, the miRNAs related to fat deposition during the growth and development of rabbits are poorly defined. In this study, miRNA-sequencing and bioinformatics analyses were used to profile the miRNAs in rabbit perirenal adipose tissue at 35, 85 and 120 days post-birth. Differentially expressed (DE) miRNAs between different stages were identified by DEseq in R. Target genes of DE miRNAs were predicted by TargetScan and miRanda. To explore the functions of identified miRNAs, Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed. Approximately 1.6 GB of data was obtained by miRNA-seq. A total of 987 miRNAs (780 known and 207 newly predicted) and 174 DE miRNAs were identified. The miRNAs ranged from 18nt to 26nt. GO enrichment and KEGG pathway analyses revealed that the target genes of the DE miRNAs were mainly involved in zinc ion binding, regulation of cell growth, MAPK signaling pathway, and other adipose hypertrophy-related pathways. Six DE miRNAs were randomly selected and their expression profiles were validated by q-PCR. In summary, we provide the first report of the miRNA profiles of rabbit adipose tissue during different growth stages. Our data provide a theoretical reference for subsequent studies on rabbit genetics, breeding and the regulatory mechanisms of adipose development.
MSME PERFORMANCE IMPACTED BY IT ADOPTION-AN APPRAISAL OF LITERATURE FROM DEVELOPING AND DEVELOPED COUNTRIES

In any developing country, Micro, Small & Medium Enterprises (MSMEs) hold the position as the biggest contributor to economic growth. Building on a review of the theoretical and empirical literature, the purpose of this paper is to analyze the benefits of IT adoption in MSMEs in other developing and developed countries. It intends to pave the way for MSMEs to realise that the benefits overweight the challenges. Central questions are: What are the major factors influencing IT adoption in MSMEs? What are the perceived benefits of IT adoption? The paper does a literature review of empirical and non-empirical research papers published in developing and developed countries. From the review of literature, a conceptual framework of the influencing factors on MSME is formed. It further dwells into the benefits of IT adoption and suggests an outlook for the MSMEs.
De la régression logistique vers un modèle additif généralisé : un exemple d'application

Nous presentons un probleme de modelisation en regression logistique sur un exemple medical: comment expliquer la survenue d'un enfant malforme chez des parents «porteurs sains» d'une anomalie chromosomique de structure, a partir de la connaissance de mesures cytogenetiques? Apres une modelisation de type regression logistique «classique» qui s'avere satisfaisante aux yeux des cytogeneticiens, on est amene a chercher si des liens non lineaires seraient plus appropries. La technique recente des modeles additifs generalises peut-elle s'averer efficace dans cette problematique? Nous proposons ici une demarche empirique et exposons le gain obtenu sur la base de donnees etudiee
Psychometric evaluation of the Polish version of the Adherence to Refills and Medications Scale (ARMS) in adults with hypertension

Background: Only 50%–75% of chronically ill patients take their medication as prescribed. The patient is found to adhere to treatment correctly and optimally if they accomplish 80% or more of the treatment plan. A questionnaire titled the Adherence to Refills and Medications Scale (ARMS) has been used in studies involving various populations and proved to be a simple instrument for measuring adherence, with good psychometric properties. Objective: The aim of this study was to develop a Polish version of the ARMS (ARMS-P), an instrument that identifies levels of adherence in the hypertensive population, and evaluate its psychometric properties. Methods: This cross-sectional study included 279 patients, including 166 females (mean age 66.5 years), hospitalized between September 2016 and March 2017 in the Department of Internal Medicine, Occupational Diseases, and Hypertension of Wrocław Medical University, Poland. The 12-item ARMS was translated from English into Polish. The 12 items included in the final questionnaire comprise two subscales: adherence to taking medications (eight items) and adherence to refilling prescriptions (four items). Results: Patients in the good-adherence group were younger ( P = 0.017; P = 0.048), more likely to be professionally active ( P = 0.041), better educated ( P = 0.037), and more likely to have normal blood pressure ( P  0.001). They also measured their blood pressure more often ( P  0.001), and took fewer pills in a day ( P  0.001). Adherent patients were also more likely to take their medication on their own ( P = 0.016) and read information leaflets on the medication ( P  0.001). The study demonstrated that the ARMS-P questionnaire has good psychometric properties that enable its use for assessing adherence in chronically ill patients, including in particular, patients with hypertension. Conclusion: The psychometric properties of the questionnaire are satisfactory (reliability measured by means of Cronbach’s α ). The ARMS-P questionnaire proved to be suitable for use in the Polish population. The use of this screening tool for the assessment of adherence to treatment is recommended in this population of hypertensive patients.
a meta-analysis of data associating DRD4 gene polymorphisms with schizophrenia

: To explore the association between DRD4 polymorphisms and schizophrenia risk, a meta-analysis was carried out with 41 case–control articles. Specifically, we included 28 articles (5,735 cases and 5,278 controls) that pertained to the 48 bp variable number tandem repeat (VNTR) polymorphism, nine articles (1,517 cases and 1,746 controls) that corresponded to the 12 bp tandem repeat (TR), six articles (1,912 cases and 1,836 controls) that addressed the 120 bp TR, 10 articles (2,927 cases and 2,938 controls) that entailed the − 521 C . T polymorphism, six articles (1,735 cases and 1,724 controls) that pertained to the − 616 C . G polymorphism, and four articles (1,191 cases and 1,215 controls) that involved the − 376 C . T polymorphism. Pooled analysis, subgroup analysis, and sensitivity analysis were performed, and the data were visualized by means of forest and funnel plots. Results of pooled analysis indicated that the − 521 CC variant ( P z = 0.009, odds ratio [OR] = 1.218, 95% confidence interval [CI] = 1.050–1.413) and genotype L/L (ie, long allele) of the 120 bp TR were risk factors of schizophrenia ( P z = 0.004, OR = 1.275, 95% CI = 1.081–1.504). The 48 bp VNTR, the 12 bp TR, the − 616 C . G polymorphism, and the − 376 C . T polymorphism were not associated with schizophrenia. Additional research is warranted to explore the association between polymorphisms of DRD4 and schizophrenia risk.
Evaluation of phytochemical antioxidant levels by hydrogen peroxide scavenging assay

The aim of this study was to determine the antioxidant capacity of some phytochemicals by using an H2O2 scavenging assay. Betaine, Allantoin and Nicotinamide were put to the test. Even though hydrogen peroxide (H2O2) is not intrinsically reactive, it can be transformed into the extremely reactive and harmful hydroxyl radical (HO), which is then able to interact with nucleotides in deoxyribose nucleic acid and in that way trigger breakage of the strand resulting in carcinogenesis, mutagenesis, etc. Antioxidants aid in the protection of cells from the harmful effects of reactive oxygen species that are known to induce oxidative stress. Excessive production of these reactive oxygen species in the human body is associated with many chronic degenerative diseases such as diabetes, neurodegenerative disease, cancer, etc. The effective way to minimize levels of oxidative stress is the ability to scavenge these reactive oxygen species (ROS). Also, phytochemicals are able to act as antioxidants, and in that way play a vital role in the prevention of disease caused by oxidative stress. The ability of a compound to scavenge H2O2 is a good predictor of its potential antioxidant function. The hydrogen peroxide (H2O2) scavenging assay was determined using the Ruch et al., 1989 method, and a UV-VIS spectrophotometer. In conclusion, our samples had marvellous H2O2 scavenging activity and possessed good antioxidant capability, and were compared with the ascorbic acid (vitamin c) as standard natural antioxidant/ as reference antioxidant. The samples were also able to scavenge H2O2 in a concentration-dependent way, according to our results
Human Geography of the Late Upper Paleolithic in Western Europe: Present State of the Question

The indications of human abandonment of northwestern Europe and of increased population density in southwestern Europe during the Last Glacial Maximum (centered on 18-20,000 B.P.) are linked in a proposed causal relationship. Evidence for subsistence intensification and growth of socioterritorial complexity associated with developments in cave art in the Franco-Cantabrian region are intepreted in light of the human geographical and environmental background. The localized "Solutrean" phenomenon is seen as an indication of the existence of a human refugium in the favored environments of southwestern Europe, while the "Magdalenian" is interpreted as evidence of a biogeographical rebound on the part of hunter-gatherer populations under less severe Tardiglacial conditions in western Europe. The general model is one which seeks to explore the effects of range contraction and reexpansion upon the complex of human adaptive strategies.
Identification of a Munc 13-sensitive step in chromaffin cell large 1 dense-core vesicle exocytosis 2

1 dense-core vesicle exocytosis 2 Kwun-nok M. Man, Cordelia Imig, Alexander M. Walter, Paulo S. 3 Pinheiro, David R. Stevens, Jens Rettig, Jakob B. Sørensen, Benjamin 4 H. Cooper, Nils Brose, and Sonja M. Wojcik. 5 6 Department of Molecular Neurobiology, Max Planck Institute of Experimental 7 Medicine, D-37075 Göttingen, Germany 8 Leibniz Institute for Molecular Pharmacology, D-13125 Berlin, Germany 9 Department of Neuroscience and Pharmacology, Faculty of Health and Medical 10 Sciences and Lundbeck Foundation Center for Biomembranes in Nanomedicine, 11 University of Copenhagen, 2200N Copenhagen, Denmark 12 Department of Physiology, Saarland University, D-66421 Homburg, Saar, Germany 13
FORMULATION AND EVALUATION OF FLOATING TABLET OF METOPROLOL SUCCINATE USING COMBINATION OF POLYMERS

the the The research was aimed to formulate and evaluate floating tablets of Metoprolol Succinate using a combination of natural polymers such as guar gum and xanthan gum as well as a combination of natural and synthetic polymer such as guar gum and HPMC by direct compression and wet granulation method. Metoprolol succinate is a β1- selective adrenergic blocker, used in the management of hypertension, angina pectoris etc. Since the drug has relatively short half-life about 3-7hrs, multiple administration is required every 3-7hrs. The addition of gel-forming polymer, and gas-generating agent was essential to achieve buoyancy. Pre -compression parameters like angle of repose, flow rate, bulk density, tapped density, carr’s index and hausner's ratio of all formulations showed good flow properties. The four batches of floating tablets were formulated with different polymers and were evaluated for hardness, friability, weight variation, drug content uniformity, Invitro buoyancy, swelling Index, Invitro drug release, adhesion retention period. The formulations containing natural polymers have better-sustained release. It releases the drug upto 12hrs and also shows good buoyancy. The formulation containing (Guar gum + Xanthan gum) prepared by wet granulation method was found to be best among all the formulation batches. It shows floating lag time (20sec) and prolonged floating duration upto (12 hrs) which was controlled release characteristic. The maximum release observed at 11 hrs was 98.88%. The result indicate that floating tablet of Metoprolol Succinate containing Guar gum and Xanthun gum prepared by wet granulation method provide better option for controlled release and improve bioavailability.
Target and distractor learning in visual search :age-related differences

Education 1987 1991 Georgia Institute of Technology Degree: Doctor of Philosophy in Psychology (1991) Thesis: An analysis of ability-performance relationships as a function of practice and age. (APA Division 21 Briggs Dissertation Award) Degree: Master of Science in Psychology (1989) Thesis: Target and distractor learning in visual search: Age-related differences. (Monie A. Ferst Sigma Xi Thesis Award)
association of systolic blood pressure drop with intravenous administration of itraconazole in children with hemato-oncologic disease

Purpose: Although few adverse effects have been reported for itraconazole, a widely used antifungal therapy for febrile neutropenia, we found intravenous (IV) itraconazole to be associated with serious cases of blood warranted during IV administration of itraconazole in this group of patients.
Targeting the Human Cancer Pathway Protein Interaction Network by Structural Genomics*

Structural genomics provides an important approach for characterizing and understanding systems biology. As a step toward better integrating protein three-dimensional (3D) structural information in cancer systems biology, we have constructed a Human Cancer Pathway Protein Interaction Network (HCPIN) by analysis of several classical cancer-associated signaling pathways and their physical protein-protein interactions. Many well known cancer-associated proteins play central roles as “hubs” or “bottlenecks” in the HCPIN. At least half of HCPIN proteins are either directly associated with or interact with multiple signaling pathways. Although some 45% of residues in these proteins are in sequence segments that meet criteria sufficient for approximate homology modeling (Basic Local Alignment Search Tool (BLAST) E-value <10−6), only ∼20% of residues in these proteins are structurally covered using high accuracy homology modeling criteria (i.e. BLAST E-value <10−6 and at least 80% sequence identity) or by actual experimental structures. The HCPIN Website provides a comprehensive description of this biomedically important multipathway network together with experimental and homology models of HCPIN proteins useful for cancer biology research. To complement and enrich cancer systems biology, the Northeast Structural Genomics Consortium is targeting >1000 human proteins and protein domains from the HCPIN for sample production and 3D structure determination. The long range goal of this effort is to provide a comprehensive 3D structure-function database for human cancer-associated proteins and protein complexes in the context of their interaction networks. The network-based target selection (BioNet) approach described here is an example of a general strategy for targeting co-functioning proteins by structural genomics projects.
Relation Between Math Anxiety and Playing Computer Games: Students Perceptions

: Mathematics is seen as the most frustrating subject and has the highest failure rate, and is the subject that students tend to fear the most, and this anxiety turns into a math phobia. Due to the complexity of mathematics, some students are anxious about learning it. Therefore, the objective of this paper was to analyze the relationship of playing computer games to the level of mathematical anxiety in students. The methodology chosen for this study is a correlational research design. The selected sample was represented by 76 students from the music high school "Lorenc Antoni" and the lower school "Heronjtë e Lumës" Prizren from Kosovo. A questionnaire with two sections was used for data collection, where the first section measures the level of students' anxiety about mathematics and the second section measures students' liking for computer games. The results from this research show that there is a correlation between students' anxiety about mathematics and playing computer games, and vice versa. Consequently, it is argued from students' perceptions that their mathematics anxiety is likely to affect the learning environment by playing computer games.
Occupational Therapy Students’ Perceptions of Feedback During Pre-Fieldwork Simulation Debrief: Useful and Why

Abstract Simulation is increasingly used in occupational therapy education with the objectives of developing practice skill competency and enhancing clinical reasoning. Debriefing, an integral part of the simulation process, is critical to achieving these objectives. This study sought to determine the types of debrief feedback Master of Science in Occupational Therapy (MScOT) students perceived as most useful and why, and how the advocacy inquiry model of debriefing influenced self-reported increases in clinical reasoning, client care, and planned implementation of feedback in practice. Using an embedded mixed method design with secondary data analysis, sixty-three first-year MScOT students provided 357 descriptions of the most useful feedback they received during 10-minute, facilitator-led debrief sessions after six simulations. Qualitative analysis revealed useful feedback was related to specific skills, interviewing and communication, the process of practice, strengths and encouragement, and client-centeredness. The advocacy inquiry approach was a useful delivery method of feedback. Logistic regression indicated that reported use of the advocacy inquiry model increased the likelihood by 4.7 times that students reported the debrief facilitated clinical reasoning. When advocacy inquiry was used in conjunction with providing feedback on specific skills, students were 5.3 times more likely to report planned implementation of the feedback in practice. Students value a variety of types of feedback during simulation debriefs. Debriefs using the advocacy inquiry method may be particularly useful for facilitating the development of clinical reasoning in the context of simulation-based fieldwork education.
RELACIÓN ENTRE EL USO DE LA TIERRA Y SU FERTILIDAD EN LAS LADERAS DE LA SIERRA NORTE DE OAXACA, MÉXICO RELATIONSHIP BETWEEN LAND USE AND SOIL FERTILITY ON THE HILLSIDES OF THE SIERRA NORTE OF OAXACA, MÉXICO

Soil management under hillside conditions requires special care because of the risks of erosion and degradation. In these terrains, land use varies from primary forests to intensive agriculture, and changes in use are frequent. Hillside lands of the Sierra Norte of Oaxaca have suffered an intense change of use, but its effect on chemical soil properties, particularly those related to fertility, has not been studied. Diagnosing the changes in these hillside soils at due time can be useful for their adequate management and for relieving the impact of their exploitation. In this paper, pH, organic matter and organic carbon (MO and Corg), nitrogen (N), extractable Olsen phosphorus (Pols), exchangeable calcium, potassium, magnesium, and sodium (Cai, Ki, Mgi, and Nai), exchangeable acidity (Ai), exchangeable bases (SB), and cationic exchange capacity (CIC) -chemical properties related to hillside soil fertility –were evaluated in three microwatersheds, representative of ethnic regions with high degree of marginalization (Mazateca, Cuicateca, and Mixe) of the Sierra Norte of Oaxaca. Within each micro-watershed, the land use system affects chemical soil properties. For example, pH of the systems with forestry use within each micro-watershed was lower than the one of those with agricultural use, whereas the MO percentage in the soil of systems with annual agricultural use was similar or higher than that of some forestry systems. Independently of the micro-watershed, the land use systems related to agriculture: coffee, traditional tilling, conservation tillage, and maize intercropped with fruit trees, presented the highest contents of Pols and MO; therefore, these systems may be an alternative for land use in hillside areas.