Miracle-dz/UniFAR-FTUs huggingface dataset:
The BP Oil Spill

College Station, September 19 – The Mosbacher Institute brought together an expert panel to discuss the ecological and commercial consequences of the massive spill in the Gulf of Mexico following the now-infamous explosion on the BP Deepwater Horizon drilling platform at the Macondo oil well last year. The panel spoke to an audience of some 70 faculty and students at the Bush School of Government and Public Service.
Quantitative Eeg and Low Resolution Electromagnetic Tomography (loreta) Imaging of Patients with Persistent Auditory Hallucinations

Electrophysiological studies have demonstrated gamma and beta frequency oscillations in response to auditory stimuli. The purpose of this study was to test whether auditory hallucinations (AH) in schizophrenia patients reflect abnormalities in gamma and beta frequency oscillations and to investigate source generators of these abnormalities. This theory was tested using quantitative electroencephalography (qEEG) and low-resolution electromagnetic tomography (LORETA) source imaging. Twenty-five schizophrenia patients with treatment refractory AH, lasting for at least 2 years, and 23 schizophrenia patients with non-AH (N-AH) in the past 2 years were recruited for the study. Spectral analysis of the qEEG and source imaging of frequency bands of artifact-free 30 s epochs were examined during rest. AH patients showed significantly increased beta 1 and beta 2 frequency amplitude compared with N-AH patients. Gamma and beta (2 and 3) frequencies were significantly correlated in AH but not in N-AH patients. Source imaging revealed significantly increased beta (1 and 2) activity in the left inferior parietal lobule and the left medial frontal gyrus in AH versus N-AH patients. These results imply that AH is reflecting increased beta frequency oscillations with neural generators localized in speech-related areas.
Molecularly Targeted Therapy Using Bevacizumab for Non-Small Cell Lung Cancer: a Pilot Study for the New CT Response Criteria

Objective We wanted to compare the efficacy of the new CT response evaluation criteria for predicting the tumor progression-free survival (PFS) with that of RECIST 1.1 in non-small cell lung cancer (NSCLC) patients who were treated with bevacizumab. Materials and Methods Sixteen patients (M:F = 11:5; median age, 57 years) treated with bevacizumab and combined cytotoxic chemotherapeutic agents were selected for a retrospective analysis. The tumor response was assessed by four different methods, namely, by using RECIST 1.1 (RECIST), RECIST but measuring only the solid component of tumor (RECISTsolid), the alternative method reflecting tumor cavitation (the alternative method) and the combined criteria (the combined criteria) that evaluated both the changes of tumor size and attenuation. To evaluate the capabilities of the different measurement methods to predict the patient prognosis, the PFS were compared, using the log rank test, among the responder groups (complete response [CR], partial response [PR], stable disease [SD] and progressive disease [PD]) in terms of the four different methods. Results The overall (CR, PR or SD) response rates according to RECIST, RECISTsolid, the alternative method and the combined criteria were 81%, 88%, 81% and 85%, respectively. The confirmed response rates (CR or PR) were 19%, 19%, 50% and 54%, respectively. Although statistically not significant, the alternative method showed the biggest difference for predicting PFS among the three response groups (PR, SD and PD) (p = 0.07). RECIST and the alternative method showed a significant difference for predicting the prognosis between the good (PR or SD) and poor overall responders (p = 0.02). Conclusion The response outcome evaluations using the three different CT response criteria that reflect tumor cavitation, the ground-glass opacity component and the attenuation changes in NSCLC patients treated with bevacizumab showed different results from that with using the traditional RECIST method.
A Polymorphic Variant in Human Mdm4 Associates with Accelerated Age of Onset of Estrogen Receptor Negative Breast Cancer Department of Surgical Oncology And

Murine double minute 4 (MDM4) shares significant structural ho-mology with murine double minute 2 (MDM2) and interacts and regulates transcriptional activity of the tumor suppressor p53. In tumors with wild-type p53, there is often overexpression of MDM2 or MDM4 leading to functional inactivation of p53. A single-nucleotide polymorphism (SNP) in the promoter of human MDM2 (SNP309) was shown to associate with increased MDM2 expression and increased risk of cancer. This study evaluated the association of a SNP in human MDM4 (C>T) with age of onset of breast cancer in two independent cohorts. In cohort 1 of 675 patients , the average age of diagnosis for women with estrogen receptor (ER)-positive and ER-negative breast cancers was 53.2 and 48 years, respectively. In this cohort, homozygous variant (TT) carriers developed ER-negative carcinomas at an earlier age than homozygous wild-type (CC) or heterozygous (TC) such that the age at diagnosis was accelerated by 5.
Evaluation of adrenal reserve in patients with differential thyroid cancer receiving thyroid hormone suppression therapy- case-control comparative study

Background Patients with differentiated thyroid cancer (DTC) are exposed to subclinical exogenous hyperthyroidism for the suppression of thyroid-stimulating hormone (TSH). In this study, we aimed to evaluate the adrenal reserve in DTC patients receiving suppression therapy. Materials and Methods The study included 55 DTC patients on suppression therapy and 32 healthy volunteers. Basal serum cortisol of all participants and adrenocorticotropic hormone (ACTH) of the patient group were measured. A standard-dose ACTH test (0.25 mg) was performed in patients with a basal cortisol < 14.5 mcg/dL. Results
Evaluating the Sustainability of Heritage Tourism and Historic Preservation in New Bern, North Carolina

After nearly a half century of suburbanization economic development specialists and urban planners have begun to appreciate the unique aesthetic and heritage landscapes of underutilized downtown areas as potential geographic spaces for economic growth. Consequently fostering heritage tourism and recreation industries that take advantage of these unique spaces has become a cornerstone of many downtown redevelopment plans. A growing pool of literature on the subject of sustainable tourism has noted that heritage tourism is ideologically and institutionally different from other forms of the industry as concepts of long term planning cultural awareness and resource conservation are important to both tourism sustainability and heritage management. While there is an increasingly diverse collection of literature available on the subject of sustainable urban heritage tourism there is greater need for more studies of this unique type of tourism in a market environment and to assess the degree to which heritage tourism and historic preservation are sustainable as a viable industry according to information gathered through chiefly qualitative methods. This thesis focuses specifically on the socio-cultural sustainability of heritage tourism and historic preservation in the area of downtown New Bern North Carolina. Interpretation and presentation of preservation and heritage are applied selectively and there is dissonance and disagreement amongst certain groups concerning the role of tourism in New Bern. Nevertheless qualitative research shows that community support economic diversity long term management and conservation of the built and natural environment qualify New Bern's urban heritage tourism industry as more sustainable than tourism industries elsewhere.
Roles of Accessory Subunits in (cid:1) 4 (cid:2) 2* Nicotinic Receptors

Accessory subunits in heteromeric nicotinic receptors (AChRs) do not take part in forming ACh binding sites. (cid:1) 5 and (cid:2) 3 subunits can function only as accessory subunits. We show that both (cid:1) 5 and (cid:2) 3 efficiently assemble in human (cid:1) 4 (cid:2) 2* AChRs expressed in permanently transfected human embry- onic kidney (HEK) cell lines. Only ( (cid:1) 4 (cid:2) 2) 2 (cid:1) 5, not ( (cid:1) 4 (cid:2) 2) 2 (cid:2) 3 AChRs, have been detected in brain. The (cid:1) 4 (cid:2) 2 (cid:1) 5 line expressed 40% more AChRs than the parent (cid:1) 4 (cid:2) 2 line and was equally sensitive to up-regulation by nicotine. The (cid:1) 4 (cid:2) 2 (cid:2) 3 line expressed 25-fold more AChRs than the parental line and could not be further up-regulated by nicotine. Relative sensitivity to activation by ACh depends on the accessory subunit, (cid:2) 2 con-ferring the greatest sensitivity, (cid:1) 5 less, and (cid:2) 3 and (cid:1) 4 much less. Accessory subunits form binding sites for positive alloste- ric modulators, as illustrated by the observation that (cid:1) 5 con-ferred high sensitivity to galanthamine. In the presence of (cid:1) 5 or (cid:2) 3, stable, partially degraded, dead end intermediates accu-mulated within the cells. These may have the form (cid:1) 5 (cid:1) 4 (cid:2) 2 (cid:1) 5. The efficiency with which (cid:1)
Study on classification based on image fusion with curvelet transform

Curvelet transform for image fusion can represent directional edges better than wavelet-based method, and can preserve spectral information more effectively as well. The abilities of capturing texture characteristics of high-resolution images and keeping color information of multispectral (MS) images make the fused images suitable to be classified for higher classification accuracy. To test the effect of curvelet transform on images classification, this paper uses a tunable HIS_Brovey method and curvelet-based method to fuse panchromatic (PAN) and MS IKONOS images respectively at first; then classifies the original MS image and the two fused images, the same training sites of samples are selected during the classification processing; and finally evaluates the classified images. The results show that original MS image, the HIS-Brovey-based fused image and curvelet-based fused image have the overall classification accuracies of 79.80%, 82.83% and 86.87% respectively, among which the curvelet-based classified image obtains the highest accuracy, which indicates that curvelet-based image fusion is more suitable for classification compared with the tunable HIS-Brovey-based fusion method.
The CNES_CLS11 Global Mean Sea Surface Computed from 16 Years of Satellite Altimeter Data

This article focuses on the determination and the validation of the new Mean Sea Surface from the CNES/CLS. This new model merges multiple satellite altimeters over 16 years of observations. Particular attention was paid on the analysis of the oceanic variability. Then a novel method was applied to remove this variability and to take into account different kinds of errors that affect the data. Several types of validations were performed to estimate the quality of the shortest topographic structures and to quantify the accuracy of the mean oceanic content at a larger scale.
Individuos centrales como protagonistas del proceso de innovación: un estudio con blogs españoles relacionados con alimentación = Central individuals as leading actors in the innovation process: a case study with Spanish food-related weblogs

En el momento actual, el sector agroalimentario espanol atraviesa una de sus etapas mas inciertas. Mientras el consumo extradomestico se desploma, el domestico se ralentiza por la busqueda de formulas mas racionales que resulten en un menor gasto. Las exportaciones, la valvula de escape, crecen a ritmos nunca antes vistos abriendose paso en escenarios internacionales especialmente regulados. Como consecuencia de este entorno, el esfuerzo dirigido hacia la innovacion se convierte en ineludible para las companias del sector. Ante este hecho, el mismo consumidor se perfila como un recurso muy importante para la obtencion de informacion acerca de nuevas ideas y necesidades no satisfechas que, gracias a Internet y a la Web 2.0 , se encuentra ahora mas que nunca al alcance de la empresa. Este trabajo de investigacion aborda el estudio de una de estas redes sociales online , basado en el examen del comportamiento innovador de los individuos que las forman y en la identificacion de aquellos que socialmente destacan sobre los demas. El documento finaliza con una reflexion y justificacion globales e indica ademas ciertos aspectos de utilidad para el mundo empresarial y sendas lineas de investigacion futura. The Spanish food sector experiences at the present an especially uncertain conjunction. Whereas the extra-domestic consumption collapses, the domestic consumption slows down. Moreover, consumers look for more rational options at lower costs. In contrast, exports grow at really high rates in particularly regulated international scenarios. As a result of this scene, innovation efforts are unavoidable for food companies. In view of this, the very consumer, who is now easily reachable on the Internet and Web 2.0, represents a valuable resource for obtaining information about new ideas and uncovered needs. This research paper, working with one of these online social networks, presents an examination of the innovative behavior of individuals who conform them and identifies those who are more socially prominent when compared to the rest. Finally, the study concludes indicating aspects of general concern as well as some brief pieces of advice for practitioners and possible future lines of research
Towards Programming the Radio Environment with Large Arrays of Inexpensive Antennas

Conventional thinking treats the wireless channel as a constraint, so wireless network designs to date target endpoint designs that best utilize the channel. Examples include rate and power control at the transmitter, sophisticated receiver de-coder designs, and high-performance forward error correction for the data itself. We instead explore whether it is possible to reconﬁgure the environment itself to facilitate wireless communication. In this work, we instrument the environment with a large array of inexpensive antenna (LAIA) elements, and design algorithms to conﬁgure LAIA elements in real time. Our system achieves a high level of programmability through rapid adjustments of an on-board phase shifter in each LAIA element. We design a channel decomposition algorithm to quickly estimate the wireless channel due to the environment alone, which leads us to a process to align the phases of the LAIA elements. Variations of our core algo-rithm then improve wireless channels on the ﬂy for single-and multi-antenna links, as well as nearby networks operating on adjacent frequency bands. We implement and deploy a 36-element LAIA array in a real indoor home environment. Experiments in this setting show that, by reconﬁguring the wireless environment, we can achieve a 24% TCP throughput improvement on average and a median improvement of 51.4% in Shannon capacity over baseline single-antenna links. Over baseline multi-antenna links, LAIA achieves an improvement of 12.23% to 18.95% in Shannon capacity.
JMIR Serious Games

This editorial provides a behavioral science view on gamification and health behavior change, describes its principles and mechanisms, and reviews some of the evidence for its efficacy. Furthermore, this editorial explores the relation between gamification and behavior change frameworks used in the health sciences and shows how gamification principles are closely related to principles that have been proven to work in health behavior change technology. Finally, this editorial provides criteria that can be used to assess when gamification provides a potentially promising framework for digital health interventions.
Sex Determination of Human Mandible Using Metrical Parameters

InTROdUCTIOn Sex determination of bone is a very important part of study in Anthropology and Forensic science, as further interpretations and analysis will be based on it. Normally morphological and metric methods are used to determine the sex of a bone. The advantage of metric analysis is that obtained data can be easily comparable with the other studies [1]. Sex of an unknown individual can be determined based on the data from the morphology and metric features of skull and mandible, soft tissues, forensic odontology, as well as by DNA analysis of teeth [2].
The Prevention of Schizophrenia: What Interventions Are Safe and Effective? Risk Assessment Measures Primary Prevention Prevention of Schizophrenia Prevention of Schizophrenia Secondary Prevention Prevention of Schizophrenia Tertiary Prevention Historical Antecedents of Early Intervention

Obstetric complications appear to increase the risk of developing schizophrenia, and post-World War II improvements in obstetric care may have contributed to a decline in the incidence of the illness in the developed world. Educating providers and consumers of psychiatric and obstetric services about the risk of obstetric complications in increasing the risk of schizo-phrenia could bring about a farther small decrease in the incidence of the illness, safely and at low cost. On the other hand, attempts to prevent the occurrence of schizophrenia by treating people who manifest high-risk indicators prior to the development of the illness have a low probability of success and a high probability of unintended negative consequences. Early intervention with people who have developed the full schiz-ophrenia syndrome is likely to have few negative effects and may yield benefits, although it is not yet clear that it will. Illness prevention strategies can be categorized into primary , secondary, and tertiary phases. According to Caplan (1964), primary prevention aims to prevent the occurrence of illness and to promote health; when successful it reduces the incidence (the occurrence of new cases) of an illness in the population. Secondary prevention consists of identifying illness early and intervening to decrease its duration; in this way, secondary prevention reduces prevalence (the number of currently existing cases). Tertiary prevention describes the prevention of complications and disability from an illness. This article will discuss examples of preventive interventions in each category that might conceivably be effective in schizophrenia. An example of a primary prevention approach would be a campaign to improve obstetric care for women with schizophrenia and for the first degree relatives of people with schizophrenia in an attempt to decrease the incidence of the illness in their offspring. A proposed form of secondary prevention is to treat people with pre-morbid symptoms of schizophrenia and other at-risk features before they develop the full syndrome (McGorry and Jackson 1999). Efforts to provide the earliest treatment possible to people with symptoms of the full syndrome would be considered tertiary prevention under Caplan's definition. Prevention approaches must be based on an assessment of the risk posed by potentially harmful factors. Risk measures of illness may be based on either absolute differences between groups or relative differences between groups. Measures of absolute difference are preferred when preventive interventions are being considered because the goal is usually an absolute reduction in occurrence. Population attributable risk, an …
The interleuldn-1 family: 10 years of discovery’

The appearance of this retrospective article in the December 1994 issue ofThe FASEB Journal marks anexact 10th anniversary since the seminal papers under review were published, in November and December 1984 (2, 3). Dr. Dinarelloalso wrote a review on the biology of interleukin-1 in an earlyissue of the FJ (2: 108-155, 1988), which,with its current 930 citations, has become the mostwidely quoted of any FJ review and a contributor to the total number of citations that led to the author being listed by the Institute of Scientific Information as the 8th most cited scientist in 1992.
Journal Pre-proofs Transdiagnostic Structural Neuroimaging features in Depression and Psycho‐ sis: A Systematic Review

Background: Previous research suggests that there may be similarities in structural brain changes seen in patients with depression and psychosis compared to healthy controls. However, there is yet no systematic review collating studies comparing structural brain changes in depression and psychosis. Establishing shared and specific neuroanatomical features could aid the investigation of underlying biological processes. Aims: To identify structural neuroimaging similarities and differences between patients with depression and psychosis. Method: We searched PubMed, PsychInfo, Embase, NICE Evidence, Medline and the Cochrane Library were searched from inception to 30/06/2021 using relevant subject
Development of a conditionally immortalized human pancreatic (cid:12) cell line

Diabetic patients exhibit a reduction in β cells, which secrete insulin to help regulate glucose homeostasis; however, little is known about the factors that regulate proliferation of these cells in human pancreas. Access to primary human β cells is limited and a challenge for both functional studies and drug discovery progress. We previously reported the generation of a human β cell line (EndoC- β H1) that was generated from human fetal pancreas by targeted oncogenesis followed by in vivo cell differentiation in mice. EndoC- β H1 cells display many functional properties of adult β cells, including expression of β cell markers and insulin secretion following glucose stimulation; however, unlike primary β cells, EndoC- β H1 cells continuously proliferate. Here, we devised a strategy to generate conditionally immortalized human β cell lines based on Cre-mediated excision of the immortalizing transgenes. The resulting cell line (EndoC- β H2) could be massively amplified in vitro. After expansion, transgenes were efficiently excised upon Cre expression, leading to an arrest of cell proliferation and pronounced enhancement of β cell–specific features such as insulin expression, content, and secretion. Our data indicate that excised EndoC- β H2 cells are highly representative of human β cells and should be a valuable tool for further analysis of human β cells.
Entornos virtuales 3D como herramienta para promover el trabajo colaborativo en educación

La incorporacion cada vez mas acelerada de las Tecnologias de la Informacion y la Comunicacion (TIC) a la educacion, esta generando una serie de cambios y transformaciones en las formas en que nos representamos y llevamos a cabo los procesos de ensenanza y aprendizaje. Estos cambios pueden observarse en los entornos tradicionales de educacion formal, pero tambien en la aparicion de nuevos entornos educativos basados total o parcialmente en las TIC.