Miracle-dz/UniFAR-FTUs huggingface dataset:
Monocyte and neutrophil to high density lipoprotein cholesterol ratios are elevated in patients with vitamin D deficiency

Aim: It is suggested that Vitamin D deficiency may lead to cardiovascular diseases. Monocyte-High density lipoprotein cholesterol (HDL) ratio (MHR) and Neutrophil-HDL ratio (NHR) are markers which may be used as cardiovascular risk factors, which are associated with inflammation. The purpose of this study is to evaluate the MHR and NHR levels in patients with Vitamin D deficiency. Material and Method: This retrospective study included patients who were tested for Vitamin D levels in our clinic. The subjects were separated into two groups based on their Vitamin D levels and laboratory variables including MHR and NHR were compared. Results: The subjects with serum 25 OH D level lower and higher than 20 ng/ml were compared, and MHR and NHR were detected significantly higher in subjects with Vitamin D deficiency (p:0.003 and p<0.001). Conclusion: Our study indicates for the first time in the literature that MHR and NHR levels increase in Vitamin D deficiency. Our findings suggest that the cardiovascular risk which occurs in Vitamin D deficiency may be associated with the observed increased inflammation. It was detected that MHR and NHR ratios may be used to predict cardiovascular diseases in people with Vitamin D deficiency. Our study also showed that the increased cardiovascular risk which occurs in vitamin D deficiency may be associated with the increased inflammation.
Migration Testing of GPPS and HIPS Polymers: Swelling Effect Caused by Food Simulants Compared to Real Foods

Migration kinetic data from general purpose polystyrene (GPPS) and high impact polystyrene (HIPS) were generated for a set of model substances as well as styrene monomer and oligomers at different temperatures (20 °C, 40 °C, 60 °C) using food simulants stipulated in the European Regulation (EU) 10/2011 and real foods like milk, cream and olive oil (20 °C, 40 °C). The extent of polymer swelling was characterized gravimetrically and visual changes of the test specimens after migration contact were recorded. Isooctane and 95% ethanol caused strong swelling and visual changes of HIPS, overestimating real migration into foods especially at high temperatures; GPPS was affected by isooctane only at 60 °C. With 50% ethanol, after 10 days contact at 60 °C or 40 °C both polymers were slightly swollen. Contrary, most of the real foods analyzed caused no detectable swelling or visual changes of the investigated polymers. This study demonstrates that the recommendations provided by EU regulations are not always in agreement with the physicochemical properties of styrenic polymers. The critical point remains the selection of adequate food simulants/testing conditions, since the high overestimation of aggressive media can lead to non-compliance of polystyrene materials even if the migration into real food would be of no concern.
KESEHATAN MENTAL DAN WELL-BEING PENDIDIK KRISTEN DI INDONESIA SELAMA MASA PANDEMI

Penelitian kuantitatif deskriptif ini bertujuan untuk mengetahui kondisi kesehatan mental dan well-being pendidik Kristen di Indonesia selama masa pandemic Covid-19. Pengambilan data dilakukan pada 30 Maret sampai dengan 24 April 2021. Peserta penelitian ini adalah pendidik Kristen yang mengajar di sekolah Kristen, negeri, atau swasta nasional. Hasil temuan menunjukkan pendidik Kristen di Indonesia memiliki vocational passion yang tinggi (89%), kesehatan mental yang baik (97,6%), tingkat well-being spiritual tinggi (94,8%), well-being sosial relatif baik (82,8%), well-being ekonomi cukup baik (79,4%), sedangkan well-being kesehatan hanya 52,8% yang tinggi. Sebanyak 66% pendidik memiliki kepuasan hidup yang tinggi. Uji chi square menunjukkan bahwa komponen well-being (spiritual, ekonomi, sosial, dan kesehatan) mempunyai hubungan yang signifikan dengan tingkat kesehatan mental para pendidik. Tantangan utama yang dihadapi pendidik adalah masalah: teknologi pendukung pembelajaran; kegiatan belajar mengajar yang dirasa tidak maksimal; sikap dan perilaku murid yang kurang disiplin, sopan, kooperatif, dan motivasi; kurangnya relasi dan interaksi antara guru dan guru serta sesama murid; dan beban dan jam kerja yang bertambah yang menyebabkan kelelahan kesehatan fisik dan mental. Implikasi utama dari temuan ini bagi para pengambil keputusan lembaga pendidikan Kristen di Indonesia untuk memberikan perhatian khusus well-being kesehatan dari para pendidik yang telah mengalami kelelahan fisik dengan mengevaluasi dan menyesuaikan ekspektasi, beban kerja, dan jam kerja yang jelas dan membangun ekosistem well-being di sekolah.
Curvilinear and gamma generalized linear models for modeling the dependency of air pollution levels on meteorological conditions in Kathmandu valley

Effects of meteorological parameters including confounding effects of seasonality and lag effects on air pollution levels are investigated and quantified for Kathmandu valley, Nepal using daily local temporal data of 2017-2020 available through air pollution monitoring by Department of Environment and US Embassy, Kathmandu, Nepal, and meteorology monitored by Department of Hydrology and Meteorology, Kathmandu, Nepal. Data modeling are performed through Exponential, Box-Cox transformed and Gamma Generalized Linear Models since air pollution levels are found non-normal with the presence of non-constant error variance in linear modeling. Results depict high proportions of observed air pollution variations (79%-85%) explained by the fitted models with around 5% reduction in PM 10 and PM 1 levels per 1 0 C increase in average temperature and significant increase in surface O 3 level (0.177 Box-Cox transformed value) per 1 0 C increase in average temperature. Similarly, around 0.7% and 2% decrease in PM 1 and PM 10 per 1% increase in relative humidity, 0.032 decrease in transformed value of PM 2.5 per 1 mm increase in rainfall, and 7.3% decrease in PM 10 per 1 m/s increase in wind speed are also detected. Other effects are also quantified in terms of Box-Cox transformed values for statistically significant effects due to relative humidity and wind. In conclusion, meteorological conditions are found significant contributing factors in determining air pollution levels as demonstrated by statistical modeling. On the long run, atmospheric conditions can play vital roles in air pollution situation shifts mainly due to climate change characterized by changes in meteorological values.
An Area-Based Projection Algorithm for SAR Radiometric Terrain Correction and Geocoding

This article describes a projection algorithm between radar and map coordinates based on the representation of radar samples as area elements (AEs) rather than point elements. Each AE on the map grid (geographic grid) is associated with a number of radar grid samples that intersect completely or partially the AE. The association enables the geocoding (i.e., the map projection of radar imagery) with adaptive multilooking, accurately accounting for all radar samples contributing to the geocoded elements according to topography and radar geometry. By using averaging rather than interpolation, the proposed projection does not suffer from interpolation overfitting. The area-based geocoding also enables the generation of the geocoded polarimetric covariance matrix (GCOV) and geocoded synthetic aperture radar (SAR) interferograms with adaptive multilooking. Analogously, the slant-range projection of geocoded data is improved by projecting geographic grid pixels onto the radar grid according to their corresponding location based on the radar geometry without leaving gaps. This approach is used to reduce the computation time of previously published radiometric terrain correction (RTC) algorithms, performing 3.6–6.5 times faster over multilooked data and up to 26.3 times faster over single-look data. We demonstrate the strengths of the proposed area projection (AP) algorithm for RTC and geocoding using Uninhabited Aerial Vehicle SAR (UAVSAR), Sentinel-1B, and ALOS-2/PALSAR-2 data, and evaluate the results in the context of the upcoming NASA-ISRO SAR (NISAR) mission.
Flower and Spikelet Construction in Rapateaceae (Poales)

The family Rapateaceae represents an early-divergent lineage of Poales with biotically pollinated showy flowers. We investigate developmental morphology and anatomy in all three subfamilies and five tribes of Rapateaceae to distinguish between contrasting hypotheses on spikelet morphology and to address questions on the presence of nectaries and gynoecium structure. We support an interpretation of the partial inflorescence (commonly termed spikelet), as a uniaxial system composed of a terminal flower and numerous empty phyllomes. A terminal flower in an inflorescence unit is an autapomorphic feature of Rapateaceae. The gynoecium consists of synascidiate, symplicate, and usually asymplicate zones, with gynoecium formation encompassing congenital and often also postgenital fusions between carpels. Species of Rapateaceae differ in the relative lengths of the gynoecial zones, the presence or absence of postgenital fusion between the carpels and placentation in the ascidiate or plicate carpel zones. In contrast with previous reports, septal nectaries are lacking in all species. The bird-pollinated tribe Schoenocephalieae is characterized by congenital syncarpy; it displays an unusual type of gynoecial (non-septal) nectary represented by a secretory epidermis at the gynoecium base.
SEMA5A-PLXNB3 Axis Promotes PDAC Liver Metastasis Outgrowth through Enhancing the Warburg Effect

Patients bearing liver metastasis of pancreatic adeno carcinoma (PDAC) suffer from poor prognosis due to its short duration and high mortality. Complex tumor microenvironment (TME) exists in liver metastatic niches, and tumor-associated macrophages (TAMs) have play vital roles in metastasis generation and outgrowth. We have discovered that M2 type TAM-derived SEMA5A could bind to its tumor cell-expressed receptor PLXNB3 to promote tumor cell proliferation and outgrowth. We utilized liver metastasis samples of PDAC patients, intrasplenic injection mouse models, and KrasG12D/Trp53R172H/Pdx1-Cre (KPC) mouse models for in vivo study. In mechanism investigation, we have discovered that SEMA5A-PLXNB3 axis could achieve tumor cell proliferation and survival via enhancing aerobic glycolysis termed as the Warburg effects. Targeting this axis may be a potential therapeutic approach for PDAC patients with unresectable liver metastasis.
Consumer Behavioral Intention of Adopting Emerging Healthcare Technology

Gene repair is a new emerging healthcare technology garnering increasing attention. Despite the large potential future market for gene repair, a lack of research exists between the advancement of this innovation and consumer adoption intention. This study develops a theoretical model by contextualizing the unified theory of acceptance and use of technology (UTAUT) into gene repair applications. That model is extended to this specific context by integrating the relevant constructs of perceived risks and trust. Survey data allows empirically testing this new posited model through partial least square-structural equation modeling. Results show the effectiveness of the proposed model and explain the mechanism of consumer behavioral intention in the context of a gene repair application, a proxy of emerging healthcare technology. Specifically, findings show that both social influence and facilitating conditions positively correlate with consumer behavioral intention. In addition, research on trust is extended because performance expectancy and perceived risks fully mediate the correlation between trust and consumer behavioral intention. The findings of both direct and mediation effects contribute to the technology acceptance literature and provide practical implications on the promotion of emerging healthcare technologies.
Towards ‘romantic media ideologies’: digital dating abuse seen through the lens of social media and/or dating in teenage narratives

ABSTRACT The article addresses the teenagers’ perception of those forms of teen dating violence that occur on digital media (i.e., ‘digital dating abuse,’ DDA), such as snooping around, controlling behaviors, and aggravated sexting. It contributes to the strand of studies on DDA and those on the mutual shaping relationship between technology and society by focusing on the interplay between social media usage practices and dating practices among teenagers narrating DDA. We carried out 7 focus groups in Rome with 43 high school students aged 14–16 years, in order to explore whether and how the negotiation with social media platforms and the interaction between dating partners affect the adolescents’ perception of DDA. The thematic analysis reveals that participants refer to idioms of practice informed by media ideologies when seeing DDA as an issue related to social media, or to dating scripts supported by romantic ideologies when seeing it as an issue related to dating. They oscillate between these two interpretative ‘lenses,’ thus intertwining the platform social usage norms and broader societal beliefs surrounding dating relationships. In doing so, they give rise to ‘digital dating scripts’ and ‘romantic media ideologies’ which nowadays rule their dating relationships in a very specific way.
Stability and Stabilization of Almost Periodic Piecewise Linear Systems With Dwell Time Uncertainty

This article is dedicated to the stability and stabilization of almost periodic piecewise linear systems (APPLSs) with the uncertain dwell time of subsystems. Taking into account the uncertainty in dwell time for the first time, a novel mixed-mode time-varying Lyapunov function is constructed. A sufficient condition is proposed to guarantee the exponential stability of the system, where the switching instants over each period are unknown and inaccessible except their bounds. Moreover, a periodic time-scheduled state-feedback control approach is developed to stabilize the APPLS affected by dwell time uncertainty and possibly unstabilizable subsystem dynamics. A stabilizing controller design algorithm is provided to compute the time-varying gains. The effectiveness of the proposed approach is illustrated via a numerical example involving comparative case studies.
SISTEM PENDUKUNG KEPUTUSAN PENERIMA BEASISWA BIDIKMISI DENGAN METODE AHP DAN FUZZY AHP

Mahasiswa yang menempuh pendidikan pada suatu perguruan tinggi memiliki peluang utuk mendapatkan bantuan pendidikan berupa berasiswa dari berbagai sumber. Salah satu beasiswa yang paling banya peminatnya adalahbeasiswa Bidik Misi, sehingga tak heran setiap tahun terdapat banyak sekali pendaftar calon penerima beasiswa ini. Peneliian ini dibuat untuk membangun sistem penyeleksian calon penerima beasiswa secara tepat dan cepat. Dengan adanya sistem pendukung keputusan ini dapat membantu proses penyeleksian penerimaan beasiswa dengan lebih efisien. Sistem pendukung keputusan ini menggunakan dua metode yaitu Analytic Hierarchy Process dan menggunakan Fuzzy Analytic Hierarchy Process. Dimana dalam metode AHP memiliki peran dalam penentuan kriteria dan pemberian nilai bobot awal kriteria serta melakukan uji konsisten terhadap nilai dari suatu bobot awal kriteria, lalu dilanjut dengan pengolahan data hingga melakukan perangkingan dengan menggunakan pendekatan fuzzy AHP dengan algoritam Triangular fuzzy number. Hasil akhir dari sistem ini beruapa sebuah hasil perangkingan dimana para hasil dapat dilihat dengan mengurutkan urutan paling atas hingga batas kouta maksimal penerima beasiswa. Hasil uji ketepatan perhitungan sistem dengan penggunaan metode AHP dan F-AHP dengan hasil real memiliki presentasi sebesar 70%
Estimations of free fatty acid (FFA) as a reliable proxy for larval performance in Mediterranean octocoral species

The survival, behavior and competence period of lecithotrophic larvae depends not only on the energy allocation transferred by maternal colonies but also on the amount of energy consumed to sustain embryonic, larval, and post-larval development. The objective of the present work is to understand the effect of energy consumption on the performance of lecithotrophic larvae. To this aim, we analyzed free fatty acid (FFA) content and composition of the larvae of three Mediterranean octocorals (Corallium rubrum, Eunicella singularis and Paramuricea clavata) as a proxy for energy consumption. Results showed that C. rubrum larvae consume more FFA than P. clavata, whereas the energy consumed by E. singularis larvae is high but highly variable. These results are in accordance with the larval behavior of these three species since C. rubrum larvae are characterized by their high swimming activity frequency, P. clavata larvae are almost inactive, and the swimming activity frequency of E. singularis larvae is high, although variable. The differences in FFA composition of the larvae suggest contrasting energetic strategies that could explain the differences in survival and recruitment rates. In fact, high dispersal and recruitment capacities for E. singularis larvae can be inferred from the FFA composition, whereas the high spatial and temporal variability of recruitment observed in C. rubrum may be related to the non-selective transfer of fatty acid (FA) from maternal colonies. Finally, the high recovery rates after mass mortality events observed in P. clavata could be favored by the presence of a specific FA (22:6(n-3)) related to adaptation mechanisms under environmental stresses during the first developmental stages.
Pilot Design of the 1-bit Massive MIMO with Rayleigh-fading Channel

In the wireless communication system, the pilot is essential for channel estimation. This paper study the pilot design of the 1-bit massive multi-input multi-output system with the flat Rayleigh fading channel. This paper aims to design the pilot matrix minimizing the estimation error of the Bussgang linear minimum mean squared error (BLMMSE) channel estimator, of which the estimation error is given by a closed-form formula. An approximate BLMMSE channel estimation error is derived in the low signal-to-noise ratio (SNR) region. The lower bound of the approximate channel estimation error for all possible pilot matrices is derived. The analysis shows that the pilot matrix with pairwise orthogonal and equal-norm row vectors and equal-norm column vectors is optimal in terms of approximate channel estimation error. The hypersphere-based steepest descent (HSD) algorithm is proposed to design the pilot matrix by optimizing the performance of the BLMMSE estimator. The numerical results show that the proposed HSD algorithm has a noticeable improvement in channel estimation compared with the DFT pilot and the random pilot. The HSD algorithm is also valid for the near maximum likelihood estimator and SNR mismatch.
Metoprolol Mitigates Ischemic Heart Remodeling and Fibrosis by Increasing the Expression of AKAP5 in Ischemic Heart

The harm of heart failure mainly causes patients to develop dyspnea, fatigue, fluid retention, and other symptoms, which impair patients' activity tolerance and lead to a dramatic decrease in patients' quality of life. The purpose of this study was to verify whether metoprolol regulates AKAP5 expression and test the role of AKAP5 postinjury in mitigating cardiac infarction-associated tissue remodeling and fibrosis. Sprague-Dawley (SD) rats underwent coronary artery ligation (CAL), which was followed immediately with metoprolol daily. And western blot and coimmunoprecipitation experiments were performed to detect the expression of related proteins in the sham-operated group, model group, and drug-treated group. HW/BW ratio and cardiac expression of COL1 and COL3 were increased in rats following CAL compared with shams. Treatment with metoprolol postinjury was associated with a decrease in HW/BW ratio and COL1/COL3 expression compared to uncontrolled rats. CAL resulted in decreased cardiac AKAP5 expression compared to the control group, while metoprolol treatment restored levels compared to baseline shams. Cardiac expression levels of NFATc3/p-NFATc3 and GATA4 were modest at baseline and increased with injury, whereas metoprolol suppressed gene expression to below injury-associated changes. Immunoprecipitation indicated that AKAP5 could bind and regulate PP2B. In summary, we know that metoprolol alleviates ischemic cardiac remodeling and fibrosis, and the mechanism of alleviating remodeling may improve cardiac AKAP5 expression and AKAP5-PP2B interaction.
Tumor Location as a Prognostic Factor in T1 Colorectal Cancer

The incidence of T1 colorectal cancer is expected to increase because of the prevalence of colorectal cancer screening and the progress of endoscopic treatment such as endoscopic submucosal dissection or endoscopic full-thickness resection. Currently, the requirement for additional surgery after endoscopic resection of T1 colorectal cancer is determined according to several treatment guidelines (in USA, Europe, and Japan) referring to the following pathological findings: lymphovascular invasion, tumor differentiation, depth of invasion, and tumor budding, all of which are reported to be risk factors for lymph node metastasis. In addition to these factors, in this review, we investigate whether tumor location, which is an objective factor, has an impact on the presence of lymph node metastasis and recurrence. From recent studies, left-sided location, especially the sigmoid colon in addition to rectum, could be a risk factor for lymph node metastasis and cancer recurrence. The treatment of T1 colorectal cancer should be managed considering these findings.
Functional Properties of Protein Hydrolyzate from Ribbon Fish (Lepturacanthus Savala) as Prepared by Enzymatic hydrolysis

ABSTRACT Fish protein hydrolyzates (FPH) are breakdown products of hydrolysis and are gaining importance in the field of nutraceuticals and functional foods due to their bioactive properties, high nutritional value, solubility, and digestibility. This study aimed to evaluate the effect of hydrolysis time (1–5 h) on the functional properties of FPH prepared from ribbon fish by using the alcalase enzyme. Results showed that the enzymatic hydrolysis time affected the protein content, degree of hydrolysis (DH) and properties of protein hydrolyzates. The protein content of hydrolyzates was significantly (P < .05) increased with an increase in time from 1 to 5 h. Similarly, a trend was observed in the case of DH% (P < .05) as well. Enzyme hydrolysis time had substantially changed the secondary structure of the protein that decreased the crystalline structure of protein hydrolyzate as reported in FT-IR results. On the other hand, a significant reduction in the hydrolyzates’ particle size was noticed with increased hydrolysis time. Furthermore, protein hydrolyzates (1–5 h) exhibited an enhanced solubility, oil-holding capacity, ACE-I inhibitory, and DPPH radical scavenging activity. Statistical results showed an inverse correlation between hydrolysis time and particle size (r = – 0.969), while other parameters such as DH% (r = 0.994), OHC (r = 0.984), ACE-I inhibitory (r = 0.948) and DPPH radical scavenging properties (r = 0.928) presented a positive correlation with hydrolysis time. Therefore, the present work reveals that protein hydrolyzates, when subjected to a greater enzymatic hydrolysis time, enhanced certain properties of the hydrolyzate, which may be beneficial for functional food development.