Miracle-dz/UniFAR-FTUs huggingface dataset:
Methylglyoxal products in pre-symptomatic type 1 diabetes

Introduction Progression to type 1 diabetes has emerged as a complex process with metabolic alterations proposed to be a significant driver of disease. Monitoring products of altered metabolism is a promising tool for determining the risk of type 1 diabetes progression and to supplement existing predictive biomarkers. Methylglyoxal (MG) is a reactive product produced from protein, lipid, and sugar metabolism, providing a more comprehensive measure of metabolic changes compared to hyperglycemia alone. MG forms covalent adducts on nucleic and amino acids, termed MG-advanced glycation end products (AGEs) that associate with type 1 diabetes. Methods We tested their ability to predict risk of disease and discriminate which individuals with autoimmunity will progress to type 1 diabetes. We measured serum MG-AGEs from 141 individuals without type 1 diabetes and 271 individuals with type 1 diabetes enrolled in the Fr1da cohort. Individuals with type 1 diabetes were at stages 1, 2, and 3. Results We examined the association of MG-AGEs with type 1 diabetes. MG-AGEs did not correlate with HbA1c or differ between stages 1, 2, and 3 type 1 diabetes. Yet, RNA MG-AGEs were significantly associated with the rate of progression to stage 3 type 1 diabetes, with lower serum levels increasing risk of progression. Discussion MG-AGEs were able to discriminate which individuals with autoantibodies would progress at a faster rate to stage 3 type 1 diabetes providing a potential new clinical biomarker for determining rate of disease progression and pointing to contributing metabolic pathways.
Monitoring the patient–ventilator asynchrony during non-invasive ventilation

Patient–ventilator asynchrony is a major issue during non-invasive ventilation and may lead to discomfort and treatment failure. Therefore, the identification and prompt management of asynchronies are of paramount importance during non-invasive ventilation (NIV), in both pediatric and adult populations. In this review, we first define the different forms of asynchronies, their classification, and the method of quantification. We, therefore, describe the technique to properly detect patient–ventilator asynchronies during NIV in pediatric and adult patients with acute respiratory failure, separately. Then, we describe the actions that can be implemented in an attempt to reduce the occurrence of asynchronies, including the use of non-conventional modes of ventilation. In the end, we analyzed what the literature reports on the impact of asynchronies on the clinical outcomes of infants, children, and adults.
Modeling and estimation of snow depth spatial correlation structure from observations over North America

Estimation of spatial correlations should be an integral part of objective analysis of geophysical variables. However, a statistical assessment of spatial correlations has been absent from studies of objective analysis of snow depth since its debut over 2 decades ago. We show a method for computing regional spatial correlations of observed snow depth and the daily snow depth increment and fitting them to correlation functions to estimate the correlation scale parameters. Both horizontal and vertical distance correlations are computed from station observations over a well sampled part of North America. The vertical and horizontal distance correlations are fitted to exponential functions using the least square method to estimate the correlation scale parameters including the amplitude, which represents short distance correlation. Our assessment suggests a large horizontal e-folding correlation scale for both the observed snow depth and the daily increment, with implications for improving predictions in poorly monitored areas with relatively flat topography. Over mountainous terrain, vertical e-folding correlation scale for observed snow depth is much smaller than that for the daily snow depth increment and for the snow depth increment used in operational snow analyses. That means that optimal interpolation-based analysis of the increments may be more accurate than the interpolation of snow depth data.
Dictating translations with automatic speech recognition: Effects on translators’ performance

Technologies can greatly improve translators’ productivity and reduce their workload. Previous research has found that the use of automatic speech recognition (ASR) tools for dictating translations can increase productivity. However, these studies often had small sample sizes and did not consider other important aspects of translators’ performance, such as translation quality and cognitive effort. This study aims to investigate the impact of text input method on translators’ performance in terms of task duration, time allocation, editing operations, cognitive effort, and translation quality, as well as whether text difficulty affects these factors. To do this, 60 Chinese translation trainees were randomly assigned to either a dictation group or a typing group, and completed two English-Chinese translations of varying levels of source-text difficulty. Data were collected using keylogging, subjective ratings, screen recording, and a questionnaire. The results showed that using ASR reduced the typing effort of participants without negatively affecting translation quality, but did not save time or reduce cognitive effort. No effect of text difficulty was observed. Analysis of the revisions made by the dictation group and the results of the post-test questionnaire provide insights into how ASR systems can be optimized for translation purposes.
Suicidal ideation and behavior among perinatal women and their association with sleep disturbances, medical conditions, and known risk factors

Objective Suicide is considered one of the leading causes of maternal mortality, especially among women with postpartum depression. In the current systematic review, we conducted a qualitative data synthesis of recent studies exploring novel risk factors including sleep disturbances and medical conditions, alongside known and significant risk factors for perinatal suicidality. Evidence acquisition We conducted a systematic search of the literature according to PRISMA guidelines on PubMed, PsycNET, and Scopus databases. Search terms were “pregnancy” “OR” “postpartum” “OR” “peripartum” “OR” “perinatal” “OR” “postnatal” combined with the Boolean “AND” operator with “suicide” “OR” “suicidality” “OR” “suicidal ideation” “OR” “suicidal behavior. ” Evidence synthesis The initial search yielded 1,458 records, of which 51 research reports that met inclusion criteria were analyzed. These 51 studies sampled a total of 45,942 participants. Clinically, sleep disturbance, psychopathology, and social support have been identified as dominant risk factors for suicidal behavior among pregnant and postpartum women, as well as medical conditions and aversive life events. Conclusion Monitoring sleep disturbance, depression, and perceived social support is critical given that they are significant risk factors for suicide among perinatal women. Early identification of perinatal women who may be at risk of suicide, although not depressed, is crucial. Limitations The use of tools designed to identify depression to identify suicidal risk, fail to identify women who are at risk but who do not suffer from depression. Other methodological limitations are the lack of longitudinal studies and the complexity of examining suicidal behavior in sample studies.
Approximations of marginal tail probabilities and inference for scalar parameters

SUMMARY In many situations, inference for a scalar parameter in the presence of nuisance parameters requires integration of either a joint density of pivotal quantities or a joint posterior density. For such inference, accurate approximations of marginal tail probabilities are useful to avoid high-dimensional integrals. Two tail probability approximations are developed in this paper. Numerical results given for conditional inference in location-scale and linear regression models show the approximations to be generally accurate even for small sample sizes.
Interleukin-18 and IL-18BP in inflammatory dermatological diseases

Interleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 in vivo, regulating its activity. Moreover, IL-18 exerts an influential function in host innate and adaptive immunity, and IL-18BP has elevated levels of interferon-γ in diverse cells, suggesting that IL-18BP is a negative feedback inhibitor of IL-18-mediated immunity. Similar to IL-1β, the IL-18 cytokine is produced as an indolent precursor that requires further processing into an active cytokine by caspase-1 and mediating downstream signaling pathways through MyD88. IL-18 has been implicated to play a role in psoriasis, atopic dermatitis, rosacea, and bullous pemphigoid in human inflammatory skin diseases. Currently, IL-18BP is less explored in treating inflammatory skin diseases, while IL-18BP is being tested in clinical trials for other diseases. Thereby, IL-18BP is a prospective therapeutic target.
Physiological and transcriptome analysis of Candida albicans in response to X33 antimicrobial oligopeptide treatment

Introduction Candida albicans is an opportunistic pathogenic fungus, which frequently causes systemic or local fungal infections in humans. The evolution of its drug-resistant mutants necessitate an urgent development of novel antimicrobial agents. Results Here, we explored the antimicrobial activity and inhibitory mechanisms of X33 antimicrobial oligopeptide (X33 AMOP) against C. albicans. The oxford cup test results showed that X33 AMOP had strong inhibitory activity against C. albicans, and its MIC and MFC were 0.625 g/L and 2.5 g/L, respectively. Moreover, SEM and TEM showed that X33 AMOP disrupted the integrity of cell membrane. The AKP, ROS, H2O2 and MDA contents increased, while the reducing sugar, soluble protein, and pyruvate contents decreased after the X33 AMOP treatment. This indicated that X33 AMOP could damage the mitochondrial integrity of the cells, thereby disrupting the energy metabolism by inducing oxidative stress in C. albicans. Furthermore, transcriptome analysis showed that X33 AMOP treatment resulted in the differential expression of 1140 genes, among which 532 were up-regulated, and 608 were down-regulated. These DEGs were related to protein, nucleic acid, and carbohydrate metabolism, and their expression changes were consistent with the changes in physiological characteristics. Moreover, we found that X33 AMOP could effectively inhibit the virulence attributes of C. albicans by reducing phospholipase activity and disrupting hypha formation. Discussion These findings provide the first-ever detailed reference for the inhibitory mechanisms of X33 AMOP against C. albicans and suggest that X33 AMOP is a potential drug candidate for treating C. albicans infections.
Airway remodeling heterogeneity in asthma and its relationship to disease outcomes

Asthma affects an estimated 262 million people worldwide and caused over 461,000 deaths in 2019. The disease is characterized by chronic airway inflammation, reversible bronchoconstriction, and airway remodeling. Longitudinal studies have shown that current treatments for asthma (inhaled bronchodilators and corticosteroids) can reduce the frequency of exacerbations, but do not modify disease outcomes over time. Further, longitudinal studies in children to adulthood have shown that these treatments do not improve asthma severity or fixed airflow obstruction over time. In asthma, fixed airflow obstruction is caused by remodeling of the airway wall, but such airway remodeling also significantly contributes to airway closure during bronchoconstriction in acute asthmatic episodes. The goal of the current review is to understand what is known about the heterogeneity of airway remodeling in asthma and how this contributes to the disease process. We provide an overview of the existing knowledge on airway remodeling features observed in asthma, including loss of epithelial integrity, mucous cell metaplasia, extracellular matrix remodeling in both the airways and vessels, angiogenesis, and increased smooth muscle mass. While such studies have provided extensive knowledge on different aspects of airway remodeling, they have relied on biopsy sampling or pathological assessment of lungs from fatal asthma patients, which have limitations for understanding airway heterogeneity and the entire asthma syndrome. To further understand the heterogeneity of airway remodeling in asthma, we highlight the potential of in vivo imaging tools such as computed tomography and magnetic resonance imaging. Such volumetric imaging tools provide the opportunity to assess the heterogeneity of airway remodeling within the whole lung and have led to the novel identification of heterogenous gas trapping and mucus plugging as important predictors of patient outcomes. Lastly, we summarize the current knowledge of modification of airway remodeling with available asthma therapeutics to highlight the need for future studies that use in vivo imaging tools to assess airway remodeling outcomes.
Cognitive-behavioural therapy reduces psychological distress in younger patients with cardiac disease: a randomized trial.

AIMS To test whether usual outpatient cardiac rehabilitation (CR) supplemented by a cognitive-behavioural therapy (CBT) intervention may reduce anxiety and depression compared with usual CR. METHODS AND RESULTS In this multicentre randomized controlled trial, 147 cardiac patients (67% men, mean age 54 years, 92% with coronary artery disease) with psychological distress defined as a hospital anxiety and depression scale (HADS) anxiety or depression score ≥8 were randomized to five sessions of group CBT plus usual CR (intervention, n = 74) or CR alone (control, n = 73). Patients with severe distress or a psychiatric diagnosis were excluded. The intervention was delivered by cardiac nurses with CBT training and supervised by a psychologist. A reference, non-randomized group (background, n = 41) of consecutive patients without psychological distress receiving usual CR was included to explore the effect of time on HADS score. The primary outcome, total HADS score after 3 months, improved more in the intervention than in the control group [the mean total HADS score improved by 8.0 (standard deviation 5.6) vs. 4.1 (standard deviation 7.8), P < 0.001]. Significant between-group differences were maintained after 6 months. Compared with the control group, the intervention group also had greater adherence to CR (P = 0.003), more improvement in the heart-related quality of life (HeartQoL) at 6 months (P < 0.01), and a significant reduction in cardiac readmissions at 12 months (P < 0.01). The background group had no significant change in HADS score over time. CONCLUSION Brief CBT provided by cardiac nurses in relation to CR reduced anxiety and depression scores, improved HeartQoL and adherence to CR, and reduced cardiovascular readmissions. The programme is simple and may be implemented by CR nurses.
Heat Transfer in Nanofluids—A Review

Suspended nanoparticles in conventional fluids, called nanofluids, have been the subject of intensive study worldwide since pioneering researchers recently discovered the anomalous thermal behavior of these fluids. The enhanced thermal conductivity of these fluids with small-particle concentration was surprising and could not be explained by existing theories. Micrometer-sized particle-fluid suspensions exhibit no such dramatic enhancement. This difference has led to studies of other modes of heat transfer and efforts to develop a comprehensive theory. This article presents an exhaustive review of these studies and suggests a direction for future developments. The review and suggestions could be useful because the literature in this area is spread over a wide range of disciplines, including heat transfer, material science, physics, chemical engineering and synthetic chemistry.
Sharing of misinformation is habitual, not just lazy or biased

Significance Misinformation is a worldwide concern carrying socioeconomic and political consequences. What drives its spread? The answer lies in the reward structure on social media that encourages users to form habits of sharing news that engages others and attracts social recognition. Once users form these sharing habits, they respond automatically to recurring cues within the site and are relatively insensitive to the informational consequences of the news shared, whether the news is false or conflicts with their own political beliefs. However, habitual sharing of misinformation is not inevitable: We show that users can be incentivized to build sharing habits that are sensitive to truth value. Thus, reducing misinformation requires changing the online environments that promote and support its sharing.
Very low HDL levels: clinical assessment and management

ABSTRACT In individuals with very low high-density lipoprotein (HDL-C) cholesterol, such as Tangier disease, LCAT deficiency, and familial hypoalphalipoproteinemia, there is an increased risk of premature atherosclerosis. However, analyzes based on comparisons of populations with small variations in HDL-C mediated by polygenic alterations do not confirm these findings, suggesting that there is an indirect association or heterogeneity in the pathophysiological mechanisms related to the reduction of HDL-C. Trials that evaluated some of the HDL functions demonstrate a more robust degree of association between the HDL system and atherosclerotic risk, but as they were not designed to modify lipoprotein functionality, there is insufficient data to establish a causal relationship. We currently have randomized clinical trials of therapies that increase HDL-C concentration by various mechanisms, and this HDL-C elevation has not independently demonstrated a reduction in the risk of cardiovascular events. Therefore, this evidence shows that (a) measuring HDL-C as a way of estimating HDL-related atheroprotective system function is insufficient and (b) we still do not know how to increase cardiovascular protection with therapies aimed at modifying HDL metabolism. This leads us to a greater effort to understand the mechanisms of molecular action and cellular interaction of HDL, completely abandoning the traditional view focused on the plasma concentration of HDL-C. In this review, we will detail this new understanding and the new horizon for using the HDL system to mitigate residual atherosclerotic risk.
Clonal mast cell disorders and hereditary α‐tryptasemia as risk factors for anaphylaxis

The association between Hymenoptera venom‐triggered anaphylaxis (HVA) and clonal mast cell‐related disorders (cMCD) has been known for decades. However, recent breakthroughs in peripheral blood screening for KIT p.D816V missense variant have revealed the true extent of this clinical association whilst adding to our understanding of the underlying aetiology. Thus, recent large studies highlighted the presence of KIT p.D816V among 18.2% and 23% of patients with severe Hymenoptera venom‐triggered anaphylaxis. A significant proportion of those patients have normal serum basal tryptase (BST) levels, with no cutaneous findings such as urticaria pigmentosa or other systemic findings such as organomegaly that would have suggested the presence of cMCD. These findings of an increased prevalence suggest that the impact of cMCD on anaphylaxis could be clinically underestimated and that the leading question for clinicians could be changed from ‘how many patients with cMCD have anaphylaxis? ’ to ‘how many patients with anaphylaxis have cMCD? ’. The discovery of hereditary α‐tryptasemia (HαT)—a genetic trait caused by an increased copy number of the Tryptase Alpha/Beta 1 (TPSAB1) gene‐, first described in 2016, is now known to underlie the majority of cases of elevated BST outside of cMCD and chronic kidney disease. HαT is the first common heritable genetic modifier of anaphylaxis described, and it is associated with increased risk for severe HVA (relative risk = 2.0), idiopathic anaphylaxis, and an increased prevalence of anaphylaxis in patients with cMCD, possibly due to the unique activity profile of α/β ‐tryptase heterotetramers that may potentiate immediate hypersensitivity reaction severity. Our narrative review aims to highlight recent research to have increased our understanding of cMCD and HαT, through recent lessons learned from studying their association with HVA. Additionally, we examined the studies of mast cell‐related disorders in food and drug allergy in an effort to determine whether one should also consider cMCD and/or HαT in cases of severe anaphylaxis triggered by food or drugs.
Comparison of several space target tracking filters

In this paper, we present a comparative study of several nonlinear filters, namely, extended Kalman Filter (EKF), unscented KF (UKF), particle filter (PF), and recursive linear minimum mean square error (LMMSE) filter for the problem of satellite trajectory estimation. We evaluate the tracking accuracy of the above filtering algorithms and obtain the posterior Cramer-Rao lower bound (PCRLB) of the tracking error for performance comparison. Based on the simulation results, we provide recommendations on the practical tracking filter selection and guidelines for the design of observer configurations.
Immobility and the High Risk of Not Recovering Function in Older Adults

Abstract Purpose The objective of the study was to explore the experiences of older adults with immobility posthospitalization. Design We conducted a focused ethnography qualitative study. Methods Data collection included in-depth interviews with 10 individuals ages 69–82 years who had been hospitalized for at least 1 week, field notes, and observations of mobility. An inductive approach was used to analyze the data. Findings Older adults believe mobility is a central element in their life. Hospitalizations lasting 1 week or longer often result in a loss of the older adult's ability to function as before, a pattern that we identified as The Crushing Assault: Consequences of Immobility. Rehabilitation involves a Rocky Road to Regaining Mobility that is challenging but possible. Conclusions Immobility after hospitalization has unexpected and profound consequences that are life-changing and distressing for older adults at home. Recovering function is prolonged and difficult. An individualized training program that includes flexibility and progressive resistance exercises is recommended over longer periods and with extended medical follow-up. Clinical Relevance Lingering problems with immobility at home are frequently overlooked. Active programming promoting preservation of function and an optimistic attitude as well as focusing on milestones to reach are key to optimal function.
Segmenting the Eye Fundus Images for Identification of Blood Vessels

Retinal (eye fundus) images are widely used for diagnostic purposes by ophthalmologists. The normal features of eye fundus images include the optic nerve disc, fovea and blood vessels. Algorithms for identifying blood vessels in the eye fundus image generally fall into two classes: extraction of vessel information and segmentation of vessel pixels. Algorithms of the first group start on known vessel point and trace the vasculature structure in the image. Algorithms of the second group perform a binary classification (vessel or non-vessel, i.e. background) in accordance of some threshold. We focus here on the binarization [4] methods that adapt the threshold value on each pixel to the global/local image characteristics. Global binarization methods [5] try to find a single threshold value for the whole image. Local binarization methods [3] compute thresholds individually for each pixel using information from the local neighborhood of the pixel. In this paper, we modify and improve the Sauvola local binariza.