Miracle-dz/UniFAR-FTUs huggingface dataset:
Occurrence of land-plant-specific glycerol-3-phosphate acyltransferases is essential for cuticle formation and gametophore development in Physcomitrella patens.

During the evolution of land plants from aquatic to terrestrial environments, their aerial surfaces were surrounded by cuticle composed of cutin and cuticular waxes to protect them from environmental stresses. Glycerol-3-phosphate acyltransferase (GPAT) harboring bifunctional sn-2 acyltransferase/phosphatase activity produces 2-monoacylglycerol, a precursor for cutin synthesis. Here, we report that bifunctional sn-2 GPATs play roles in cuticle biosynthesis and gametophore development of Physcomitrella patens. Land plant-type cuticle was observed in gametophores, but not in protonema. The expression of ER-localized PpGPATs was significantly upregulated in gametophores than in protonema. Floral organ fusion and permeable cuticle phenotypes of Arabidopsis gpat6-2 petals were rescued to the wild type (WT) by the expression of PpGPAT2 or PpGPAT4. Disruption of PpGPAT2 and PpGPAT4 caused a significant reduction of total cutin loads, and a prominent decrease in the levels of palmitic and 10,16-dihydroxydecanoic acids, which are major cutin monomers in gametophores. Δppgpat2 mutants displayed growth retardation, delayed gametophore development, increased cuticular permeability, and reduced tolerance to drought, osmotic, and salt stresses compared to that of the WT. Genome-wide analysis of genes encoding acyltransferase or phosphatase domains suggested that the occurrence of sn-2 GPATs with both domains may be a key event in cuticle biogenesis of land plants.
Wireless roadside inspection phase II evaluation final report.

The Federal Motor Carrier Safety Administration (FMCSA) Wireless Roadside Inspection (WRI) Program is demonstrating the feasibility and value of electronically assessing truck and coach driver and vehicle safety at least 25 times more often than is possible using only roadside physical inspections. The WRI program is evaluating the potential benefits to both the motor carrier industry and to government. Potential benefits include reduction in accidents, fatalities and injuries on our highways and keeping safe and legal drivers and vehicles moving on the highways. WRI pilot tests were conducted to prototype, test, and demonstrate the feasibility and benefits of electronically collecting safety data messages from in-service commercial vehicles and performing wireless roadside inspections using three different communication systems, Dedicated Short Range Communication (DSRC), Commercial Mobile Radio Services (CMRS), and Universal Identification. This report documents the evaluation of the WRI Program Phase II pilot testing evaluated by the University of Tennessee, under contract from the National Transportation Research Center, Inc. and funded by the Research and Innovative Technology Administration (RITA) of the USDOT.
VIBRATION OF SOLIDS AND STRUCTURES UNDER MOVING LOADS (3RD EDITION)

This book analyzes the effects of moving loads on elastic and inelastic solids, elements and parts of structures and on elastic media, namely beams, continuous beams, beams on elastic foundations, rigid-plastic beams and thin-walled beams, frames, arches, strings, plate elastic spaces and half spaces etc. Vibrations in these structures are produced by various types of moving force (loads), such as vehicles with the inertial effects of their masses and by random loads which move with constant or variable speeds along the structure. This type of loading (varying in time and space) may be found in transport engineering structures which need to carry faster and heavier vehicles while the structures over which the vehicles move are becoming slenderer and lighter. The book provides theoretical formulations for the problem, and mathematical solutions for all cases and their application to civil, mechanical, transport, naval and aircraft structures. The book describes ways to prolong the life of existing/older structures and presents a theoretical guide to the economic design of new civil, mechanical and other engineering structures, such as bridges, rails, sleeper, roadways, airport runways, tunnels, foundations for all types of highways and railways, cranes and other transport structures. (A)
The Regulatory Craft: Controlling Risks, Solving Problems, and Managing Compliance

The Regulatory Craft tackles one of the most pressing public policy issues of our time -the reform of regulatory and enforcement practice. Malcolm K. Sparrow shows how the vogue prescriptions for reform (centered on concepts of customer service and process improvement) fail to take account of the distinctive character of regulatory responsibilities -which involve the delivery of obligations rather than just services. In order to construct more balanced prescriptions for reform, Sparrow invites us to reconsider the central purpose of social regulation -the abatement or control of risks to society. He recounts the experiences of pioneering agencies that have confronted the risk-control challenge directly, developing operational capacities for specifying risk-concentrations, problem areas, or patterns of noncompliance, and then designing interventions tailored to each problem. At the heart of a new regulatory craftsmanship, according to Sparrow, lies the central notion, "pick important problems and fix them. " This beguilingly simple idea turns out to present enormously complex implementation challenges and carries with it profound consequences for the way regulators organize their work, manage their discretion, and report their performance. Although the book is primarily aimed at regulatory and law-enforcement practitioners, it will also be invaluable for legislators, overseers, and others who care about the nature and quality of regulatory practice, and who want to know what kind of performance to demand from regulators and how it might be delivered. It stresses the enormous benefit to society that might accrue from development of the risk-control art as a core professional skill for regulators.
Genome-wide identification and analysis of GDSL-type esterases/lipases in watermelon (Citrullus lanatus)

Background The GDSL esterase and lipase families play important roles in abiotic stress, pathogen defense, seed development and lipid metabolism. Identifying the lipase activity of a putative GDSL lipase is necessary to determine its function. Systematic analysis of the GDSL gene family is still lacking in Citrullus lanatus. Results In this study, we identified 65 watermelon GDSL-type esterase/lipase genes and divided these genes into 6 clades based on phylogeny. The phylogenetic relationship of watermelon GDSL genes compared with Arabidopsis thaliana GDSL esterases/lipases was also determined, and these genes were divided into four groups related to morphological development, abiotic stress response, pathogen defense, and secondary metabolism. The chromosomal location of these genes revealed that they are distributed unevenly across all 11 watermelon chromosomes. Analysis of duplication events suggested that segmental duplication and tandem duplication were the major driving forces of GDSL family evolution. Synteny analysis indicated that GDSLs in watermelon were highly homologous to those in Arabidopsis thaliana, melon and cucumber. Transcriptome analyses showed the tissue-specific and common expression of the GDSL genes in leaf and root tissues and identified nitrogen-related genes under low nitrogen (N) stress compared with optimal N conditions. Conclusions Our results provide a basis for selecting candidate watermelon GDSL genes for further studies to determine the biological functions of the GDSL genes in watermelon.
Room Temperature Logic Inverter on Epitaxial Graphene-on-Silicon Device

The inverting operation of a logic inverter, using two back-gate epitaxial graphene-on-silicon field-effect transistors (GOSFETs), is demonstrated at room temperature. Thanks to the asymmetric ambipolarity of the fabricated GOSFETs, owing to the undesirable back-gate leakage, the on/off state current has been dramatically reduced. This results in a well matched input/output voltage levels for a wide VDD range from more than 1 V down to 0.5 V. The inverting operation of the device is obtained at as low VDD bias as 0.5 V. Voltage gains higher than the unity are also obtained. The experimental results are in good agreement with the simulation results made for the case of asymmetric ambipolar transistors.
INDUCTIVE LOOP VEHICLE DETECTOR: INSTALLATION ACCEPTANCE CRITERIA AND MAINTENANCE TECHNIQUES (ABRIDGMENT)

This paper represents only one step in relieving the pressures of design and maintenance in the field of vehicle detection. The emphasis is placed on enabling the traffic engineer to predict during the design phase whether the system will work with available loop detector amplifiers. Emphasis is also on outlining an exact method of evaluating the sensitivity of a loop and lead in system before the loop detector amplifier is attached to the system. Installation acceptance testing, which includes the measurement of loop resistance, insulation resistance, and inductance, should also include a test for the sensitivity of the loop and lead in system to a standard vehicle or vehicle model. Information on maintenance techniques describes a loop - oscillater, frequency - counter test device and gives procedures and data so that the device can be used to enhance maintenance capability.
Principles of Mechanics and Biomechanics

What is biomechanics? is it moving? - force and movement of force applying the rules for balance - equilibrium solving problems with drawings - vector analysis remedial equipment - machines and mechanisms why do structures fail? - materials, human tissues and stress analysis motion and change of motion - introduction to dynamics a tendency to flow - introduction to fluid mechanics.
Transit Stops, Stations, and Transfer Facilities: Evaluating Performance from the Perspective of Transit System Managers

What makes a good transit stop, station, or transfer facility? The answer depends on who you ask. Passengers, transit system managers, adjacent businesses and residents, and local governments that host them can all have strong, and sometimes conflicting, ideas about what makes a good stop or station. This paper examines this question from the transit system managers’ perspective, who must consider both the logistical and political factors inherent to transit operations and the perspectives of customers they seek to attract to their systems. To do this we administered an online survey methodology to estimate magnitudes of perceived importance for a wide array of possible stop/station objectives. Much of the previous literature on transit stops/stations is descriptive, often listing positive attributes of a good stop/station with little explanatory analysis of (1) how listed factors contribute to transit service connectivity, (2) tradeoffs among factors, or (3) their relative importance. This paper specifically addresses this third shortcoming, creating a ranked list of objectives by operators’ stated level of importance. In a nutshell respondents believe that safety, security, and the absence of pedestrian/vehicle conflicts are most important to a good stop/station, followed by ease of transferring and cost-effectiveness. Many other factors rank much further below these. These findings suggest that transit operators are well aware of travelers’ perceptions of the importance of “out-of-vehicle” travel experiences in defining the transit experience.
Transmission Lines, Matching, and Crosstalk

ELECTRICAL LENGTH Electrical Length vs. Physical Length Standing Waves Antenna Effects and Effective Permittivity Unshielded Conductor Radiation PCB Trace Radiation Electrically-Large Ca Properties of Electrically-Small Metallic Objects CABLE MODELING Purpose of a Cable High-Fidelity Speaker Wire Candidates Selecting the Cable Model Failure of the Lumped-Circuit Model Characteristic Impedance Characteristic Impedance of a dc Power Bus Reducing the Characteristic Impedance Influence of Dielectric Constant Coax and Twin-Lead Thinly Coated Twin-Lead Beads in Coax Dielectric Resistance and Insulators Cable Capacitance and Audio Cables Grounding Strap Impedance ESD Signal Wire Guideline Twisted Pair When the Line Can Be Ignored Line Resonance Multiple Receiver Loading Proximity Effect Characteristic Impedance Formula TRANSMISSION LINES AND MATCHING Voltage Reflection and Transmission Coefficients Impedance Mismatch VSWR and SWR The Cost of a VSWR > 1 Distinguishing between the Load and Source Transient and Steady-State Input Impedance Transient Reflections Matching at the Receiver and its Cost Shunt Matching with Distributed Receivers Microstrip Branching Shunt Diode Matching Shunt RC Matching Matching at the Driver and its Cost Series Matching with Multiple Receivers Effects of Nonzero Source and Load Reflection Coefficients Signal Bounce as a Function of Time Settling Time Settling Time vs Reflection Coefficient Receiver Voltage when Rise Time = Line Delay Receiver Voltage when Rise Time
DEVELOPMENT OF THE U.S. AIR EXPRESS INDUSTRY: 1970-1990

This article describes development of the air express industry in the U.S. from 1970 through 1990. During this 20-year period, the industry matured from infancy. Services provided by air express firms began to define the acceptable level of service in the minds of many shippers. Air express development also impacted other modes of U.S. transportation. And, while U.S. air express enabled firms to expand and improve their product and service offerings, many businesses took for granted these services. This article looks at the origin of major U.S. air express services. It describes the distinguishing characteristics of air express in the U.S. and the impact of U.S. laws on this industry. Competition with the U.S. Postal Service and consolidation within the industry also are discussed. The trend toward globalization of business is covered because of its impact on air express in the U.S.
Sorafenib-associated hand-foot skin reaction: practical advice on diagnosis, mechanism, prevention, and management

ABSTRACT Introduction: Sorafenib is a multitargeted tyrosine kinase inhibitor, which has been mainly used in the treatment of advanced hepatocellular carcinoma and renal cancer. However, hand-foot skin reaction (HFSR), as one of the most common adverse reactions, have hindered its long-term clinical application. At present, the mechanism of its occurrence has not been clearly studied and it leads to the lack of effective means of intervention. This article reviews known mechanism and management methods of HFSR caused by sorafenib. Areas covered: The author reviews HFSR caused by the treatment of sorafenib including the mechanism and management. English language reports located through PubMed are reviewed. Expert opinion: There are some conjectures about the mechanism of HFSR. However, the mechanism of HFSR induced by sorafenib is still unclear at present. In the absence of understanding the mechanism of HFSR, the most common method for clinical treatment of sorafenib-induced HFSR is dose down-regulation or discontinuation of treatment, which affects efficacy and even survival. Future research should focus on the mechanism of HFSR to find out new ways for prevention. Precautionary measures before the occurrence of HFSR can also be studied in the future.
From the DoD CIO: The Net-Centric Information Enterprise

Abstract : Defense transformation hinges on the recognition that information is one of our greatest sources of power. Information can be leveraged to allow decision makers at all levels to make better decisions faster and act sooner. Ensuring timely and trusted information is available where it is needed, when it is needed, and to those who need it most is the heart of the capability needed to conduct Net-Centric Operations.
Marketing the movies

This article focuses on the evolution of the roles which marketing has played in the film industry from film’s origins to the present day. It focuses on how technological innovations and shifts in public taste have upgraded marketing considerations to its current prominence within the film world. Current filmmaking is depicted as an insecure, sometimes desperate business where marketing considerations predominate over all aspects of film production including artistic considerations.
The Impact of Congenital Heart Diseases on Growth Parameters in Children and Their Correlations with Leptin Levels

Children with congenital heart disease (CHD) prone to stunted growth by different parameters including weight, height and head circumference compared to a control groups, to accomplish such aim (110) children aged ranged (20 days – 13 years with CHD) have enrolled in this study, (83) patients with a cyanotic CHD (75.45%) and (27) cyanotic type (24.54%) were compared with (171) healthy controls of similar age and sex groups. This study was done in Al-Hilla teaching hospital during the period November 1, 2017 to October 11, 2018. The results indicate a significant (2.06) retardation in all parameters in patients with CHD related to control and there is a significant retardation in weight (z = 3.06) in children with cyanotic CHD related to a cyanotic type. Also there is a significant retardation (z = 1.01) in height gain in children with cyanotic related to a cyanotic type and finally there is a significant (z = 2.09) decrease in head circumference in children with cyanotic CHD related to a cyanotic type. Serum leptin levels were also lowered in all patients with CHD. The results concluded that children with (CHD) experience early and continues decrement of all growth parameter during their life.
Architecture on the wire: Resilience through vitality

What is clear in Man on Wire is that Petit's WTC wire-walk powerfully amplified something we experience everyday, although mostly unnoticed and wrapped in the habitual, as part of being alive: vitality, or the feeling of life itself. The event was deeply moving because it brought a whispering background movement to the foreground, shifting the ground of experience momentarily, monumentally, and memorably.
Microbiology in civil engineering : proceedings of the Federation of European Microbiological Societies Symposium held at Cranfield Institute of Technology, UK, 3-5 September 1990

Part 1: Introduction. Microbes in Civil Engineering Environments - D R Cullimore, Regina Water Research Institute, Canada. Part 2: Overviews of the Main Microbiological Processes Relevant to Civil Engineering. Microbes in Civil Engineering Environments: Biofilms and biofouling - D R Cullimore, Regina Water Research Institute, Canada . Bio-corrosion in Civil Engineering - A K Tiller, National Corrosion Service, NPL, UK . Biodeterioration - K Seal, Cranfield Biotechnology Ltd, UK. Part 3: Water Supply Engineering.0 Bacterial Growth Potential in the Distribution System - O Adams & Y Kott, Technion-Israel Institute of Technology, Israel.Engineered Water Systems and Waterborne Disease - G J Mistry & R van Woerkom, Thames Water Enterprises, UK. Study on Biofouling Forming in the Industrial Cooling Water Systems - Gy Lakatos, Ecological Institute of Kossuth University, Hungary.Part 4: Engineering Materials.0 Major Biodeterioration Aspects of Buildings in Romania - A Popescu and T Beschea, Bucharest, Romania.The Biodeterioration of Polyester Polyurethane in soil/marine contact - M J Kay, L H G Morton & E L Prince, Lancashire Polytechnic, UK.Influence of Materials on the Microbiological Colonization of Drinking Water - D Schoenen, Hygiene-Institute, W Germany.Degradation of Concrete in Sewer Environment by Biogenic Sulfuric Acid Attack - A C A van Mechelen & R B Polder, Institute for Building Materials and Structures, The Netherlands.Micromorphological Aspects of the Microbial Decay of Wood - R Venkatasamy, R Mouzouras, E B G Jones, & S T Moss, Portsmouth Polytechnic, UK.Part 5: Groundwater Engineering.0 Biofouling in Sierra Colorado Water Supply: A Case Study - R E Alcalde, Departamento Provincial de Aguas, Argentina & M A Gariboglio, Universidad Nacional de al Plata, Argentina.Iron Biofouling in Groundwater Abstraction Systems: Why and How? - P Howsam & S F Tyrrel Silsoe College, CIT, UK. Complexity of Causes of Well Yield Decrease - I Savic, Faculty of Science, University of Belgrade, Yugoslavia, F Barbic, O Krajcic, Institute for Technology of Nuclear and Other Mineral Raw Materials, Yugoslavia.Theoretical Evaluation of Production Losses from a Water Well Which Involves Biofouling - D R Cullimore, Regina Water Research Institute, Canada.Occurrence and Derivation of Iron-binding Bacteria in Iron-Bearing Groundwater - K Olanczuk-Neyman, Gdansk Technical University, Poland. \b Part 6: Land Drainage and Reclamation and Waste Disposal\b0. Biotreatment of Contaminated Land - B Ellis & R J F Bewley, Biotreatment Ltd., UK.Clogging Problems in a Subsurface Pressure Distribution System for Waste Water Disposal - G Cherier, AFBSN, J Lesavre & A Zairi, CREATE, France.Elimination of Ochre Deposits from Drainpipe Systems - A Beliovich, Ben-Gurion University of the Negev, Israel. \b Part 7: Geotechnic
Evaluating Transition Metal Barrier Heights with the Latest DFT Exchange–Correlation Functionals – the MOBH35 Benchmark Dataset

A new database of transition metal reaction barrier heights – MOBH35 – is presented. Benchmark energies (forward and reverse barriers and reaction energy) are calculated using DLPNO-CCSD(T) extrapolated to the complete basis set limit using a Weizmann1-like scheme. Using these benchmark energies, the performance of a wide selection of density functional theory (DFT) exchange–correlation functionals, including the latest from the Truhlar and Head-Gordon groups, is evaluated. It was found, using the def2-TZVPP basis set, that the ωB97M-V (MAD 1.8 kcal/mol), ωB97X-V (MAD 2.1 kcal/mol) and SCAN0 (MAD 2.1 kcal/mol) hybrid functionals are recommended. The double-hybrid functionals PWPB95 (MAD 1.6 kcal/mol) and B2K-PLYP (MAD 1.8 kcal/mol) did perform slightly better but this has to be balanced by their increased computational cost.
Cognitive and noncognitive predictors of success

Significance To examine cognitive and noncognitive predictors of success, we conducted a megaanalysis of prospective, longitudinal data on over 10,000 cadets at the US Military Academy at West Point. Cognitive ability was negatively related to physical ability and grit. While cognitive ability predicted academic and military grades, the noncognitive attributes of physical ability and grit were more prognostic of other achievement outcomes, including successful completion of initiation training and 4-y graduation. When predicting success, how important are personal attributes other than cognitive ability? To address this question, we capitalized on a full decade of prospective, longitudinal data from n = 11,258 cadets entering training at the US Military Academy at West Point. Prior to training, cognitive ability was negatively correlated with both physical ability and grit. Cognitive ability emerged as the strongest predictor of academic and military grades, but noncognitive attributes were more prognostic of other achievement outcomes, including successful completion of initiation training and 4-y graduation. We conclude that noncognitive aspects of human capital deserve greater attention from both scientists and practitioners interested in predicting real-world success.
Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations

The recent advent of endovascular procedures has created the unique opportunity to collect and analyze thrombi removed from cerebral arteries, instigating a novel subfield in stroke research. Insights into thrombus characteristics and composition could play an important role in ongoing efforts to improve acute ischemic stroke therapy. An increasing number of centers are collecting stroke thrombi. This paper aims at providing guiding information on thrombus handling, procedures, and analysis in order to facilitate and standardize this emerging research field.