Miracle-dz/UniFAR-FTUs huggingface dataset:
Building First-Order Energy Modeling Intuition in Computer Architecture Lectures

Computer architecture students today arguably do not have as close a connection to energy as they do to performance. Specifically, they are not trained to reason about energy in a quantifiable way. Architecture students are taught that performance and energy are considered equally important. However, most course material focuses on a performance-driven narrative, meaning that students learn about processors, memories, networks, and systems with a strong sense of the performance implications, but with little intuition for the energy implications. On the other hand, VLSI students concretely learn about energy, but they are immersed in a world of gates and transistors and do not connect their understanding about energy back up to the abstraction of SoC-level components. How can we bridge this gap to enable architecture students to reason about the energy implications of hardware design concepts, directly within a computer architecture class? In this work, we attempt to mitigate these challenges by introducing a teaching methodology that integrates energy into pipeline diagrams. We include examples of specific classroom tools including the representation of an energy map, and we show how pipeline diagrams augmented with an energy map can enable first-order quantitative comparisons of performance, energy, and power across different design points. The approach is simple enough for lecture, in-class activities, and in exams. We hope this approach can train future students in thinking from first principles in evaluating performance-energy tradeoffs.
Research on bipolar disorder: symptoms, etiology and treatment

Bipolar disorder (BD) is a globally prevalent mental illness that negatively impacts both personal and public health outcomes. The extant academic research on BD has achieved significant advancements. The symptoms of BD are characterized by alternating episodes of extreme mood states of mania and depression, and the causes of this psychiatric disorder can be attributed to biological factors, psychological factors and environment-gene interactions. The available treatments to this disorder including medication, electroconvulsive therapy (ECT), psychotherapy, social support, and life change. This literature focuses on the main symptoms, causes and conventional therapies for BD, intending to contribute to advances in clinical research on BD. Based on well-regarded publications in psychiatry, the paper found many limitations in the extant study of BD, and future research is thus needed to fill the research gaps.
The effects of different types of Tai Chi exercise on anxiety and depression in older adults: a systematic review and network meta-analysis

Background The body of evidence supporting the beneficial effects of Tai Chi in reducing anxiety and depressive symptoms in older adults is steadily increasing. Nonetheless, there remains a scarcity of studies directly comparing the clinical effectiveness of various Tai Chi exercises in addressing anxiety and depressive symptoms in older adults. Thus, this study aimed to systematically review and analyze the therapeutic efficacy of four types of Tai Chi interventions in enhancing anxiety and depressive symptoms in older adults. Methods During the period up to July 26, 2023, searches were conducted in the Web of Science, PubMed, the Cochrane Library, CNKI, and the Chinese Scientific Journal Database (VIP). The language scope encompassed both English and Chinese. Two independent reviewers conducted the literature review and data extraction. Review Manager 5.4 was employed for traditional meta-analysis and risk assessment, while version 15 of STATA software was used for generating evidence and funnel plots for network meta-analysis. This study was registered in PROSPERO number CRD 42023442270. Result In this analysis, a total of 20 studies were included, involving 1798 participants. The findings of the pairwise meta-analysis revealed that Tai Chi intervention was more effective than the control group in reducing anxiety (SMD: −1.19, 95% CI: −2.04, −0.34, p < 0.05) and depression (SMD: −0.65, 95% CI: −0.95, −0.65, p < 0.05) symptoms among older adults. The network meta-analysis specifically focused on anxiety symptoms and found that Yang-style Tai Chi (69.9%) had the most favorable outcome, followed by the 24-form Simplified Tai Chi (66.8%). In terms of depression symptoms, the Tai Chi Exercise Program (92.6%) had the highest performance, followed by Yang-style Tai Chi (77.9%). Conclusion The findings of this study imply that Tai Chi can have beneficial outcomes in the reduction of anxiety and depressive symptoms among older individuals. Specifically, when examining various forms of Tai Chi interventions, it was observed that Yang-style Tai Chi exhibited a greater efficacy in alleviating anxiety symptoms, whereas Tai Chi exercise programs demonstrated a higher effectiveness in improving depressive symptoms. Nonetheless, it is strongly advised that older adults select an exercise program that aligns with their interests and preferences, as this can enhance social integration and overall well-being. Systematic Review Registration https://www.crd. york.ac. uk/prospero/display_record. php? ID=CRD42023442270, identifier [CRD42023442270].
Benign Paroxysmal Positional Vertigo After Joint Replacement Surgeries: Case Series

Benign paroxysmal positional vertigo (BPPV) is characterized by brief episodes of vertigo triggered by changes in head position caused by the displacement of otoliths from the utricle to the semicircular canals, particularly the posterior canal. This study explored the potential link between BPPV, the patient's preexisting conditions, and surgery-related factors including surgical positioning, duration of the procedure, exposure to vibratory forces, and anesthesia effects. This report presents two cases of BPPV following major joint replacement surgery. The first case involved a 65-year-old male with a history of diet-controlled diabetes who had undergone right-sided total hip replacement. The second case was that of a 60-year-old female with a history of osteoporosis managed with bisphosphonate therapy and left-sided knee replacement. Both patients developed vertigo symptoms one day postoperatively and were diagnosed with BPPV. In both cases, the Dix-Hallpike test confirmed the right-sided posterior canal BPPV diagnosis, and the patients were successfully treated using the Epley maneuver. Notably, there was no recurrence of vertigo at the four-week follow-up. These cases highlight the importance of considering BPPV in patients presenting with vertigo symptoms after joint replacement surgery, especially in the presence of comorbidities like diabetes and osteoporosis which possibly increase susceptibility to BPPV. This article presents two cases of benign paroxysmal positional vertigo (BPPV) following non-otologic surgery. It explores the pathophysiological mechanism underlying BPPV after such surgeries and also discusses the diagnosis and treatment approaches. This underscores the need for prompt diagnosis and treatment of BPPV to improve postoperative outcomes.
Relationship between Internet addiction and body mass index and the predictive role of emotion dysregulation

In recent years, the widespread use of the Internet has led to increasing concerns about problematic behaviors related to excessive Internet use and their potential consequences. This study aimed to investigate the relationship between Internet addiction (IA), body mass index (BMI), and emotion dysregulation (ED). Specifically, the study aimed to determine if IA significantly predicts obesity and if both Internet addiction and obesity can be significantly predicted by ED. 367 school-attending adolescents (Mage = 13.35; SD = 0.82; 49% girls) in Tekab participated in the study. Participants completed the Difficulties in Emotion Regulation Scale (DERS) and the Internet Addiction Test (IAT), while BMI was calculated using self-reported data to assess their obesity levels. The results indicated that ED significantly predicted both IA and increased BMI levels (p < 0.001). Furthermore, IA also significantly predicted elevated BMI levels (p < 0.001). Our findings showed that ED significantly predicted both higher IA and BMI values, while IA also significantly predicted elevated BMI levels These results have important implications for treatment. To address excessive Internet use or overeating behavior in individuals with either condition, it may be necessary to target the underlying emotional dysregulation that contributes to the problem.
REGIONAL ANESTHESIA A randomized controlled trial comparing the recovery time after spinal anesthesia with 2% hyperbaric prilocaine 50 mg vs. 0.5% hyperbaric bupivacaine 12.5 mg for cystoscopic procedures

Background: Cystoscopy is a urologic procedure performed as a diagnostic or a therapeutic intervention, usually requiring spinal anesthesia (SA). Bupivacaine is a frequently used spinal anesthesia agent. However, the prolonged duration of its effect is a disadvantage. Prilocaine may be an alternative for spinal anesthesia in cystoscopy, which has a shorter duration of action compared to bupivacaine. We compared recovery time of 2% hyperbaric prilocaine 50 mg vs. 0.5% hyperbaric bupivacaine 12.5 mg for cystoscopic procedures under spinal anesthesia. Methods: This study was a randomized controlled trial involving 66 patients who underwent cystoscopy in Dr. Cipto Mangunkusumo National General Hospital under SA. Subjects were randomized into two groups, i.e. prilocaine group to receive SA with hyperbaric prilocaine 2% 50 mg + fentanyl 25 µg and bupivacaine group to receive hyperbaric bupivacaine 0.5% 12.5 mg + fentanyl 25 µg. Following SA, the time to lift the leg 45 degrees and time to regain the ability to walking unsupported were noted in both groups and statistically compared. Hemodynamic changes in SpO2 and NIBP at fixed periods, as well as adverse effects were recorded. Results: Hemodynamic changes and adverse effects were comparable between the two groups. The mean time to lift a leg 45 degrees (93.88 min vs. 180.36 min; P < 0.001) and the time until the patient walked (144.91 min vs. 259.76 min; P < 0.002) were significantly short in the prilocaine group. The mean regression time for prilocaine and bupivacaine SA was 69.36 ± 35.85 and 131.88 ± 79.43 min respectively; the difference being significant (P < 0.001). Conclusion: Hyperbaric prilocaine 2% has a shorter recovery period when compared to hyperbaric bupivacaine 0.5% for spinal anesthesia and is appropriate for the length of the cystoscopy, making it a viable spinal anesthetic option.
FAUNA FROM THE TENSLEEP SANDSTONE IN WYOMING

New collections from the Tensleep sandstone in the Wind River basin and Big Horn basin of Wyoming contain 9 species of brachiopods, 1 scaphopod, 1 gastropod, and 1 trilobite. All specimens are either referable to previously described species or are impossible to identify specifically. This fauna strengthens the conclusion that the Tensleep sandstone in this region is Des Moinesian [Pennsylvanian] in age.
Potentially Inappropriate Prescribing and Potential Prescribing Omissions and Their Association with Adverse Drug Reaction-Related Hospital Admissions

Background: This study aimed to determine the prevalence of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) and their association with ADR-related hospital admissions in patients aged ≥ 65 years admitted acutely to the hospital. Methods: Information on medications and morbidities was extracted from the Adverse Drug Reactions in an Ageing Population (ADAPT) cohort (N = 798: N = 361 ADR-related admissions; 437 non-ADR-related admissions). PIP and PPOs were assessed using Beers Criteria 2019 and STOPP/START version 2. Multivariable logistic regression (adjusted odds ratios (aOR), 95%CI) was used to examine the association between PIP, PPOs and ADR-related admissions, adjusting for covariates (age, gender, comorbidity, polypharmacy). Results: In total, 715 (90%; 95% CI 87–92%) patients had ≥1 Beers Criteria, 555 (70%; 95% CI 66–73%) had ≥ 1 STOPP criteria and 666 patients (83%; 95% CI 81–86%) had ≥ 1 START criteria. Being prescribed at least one Beers (aOR = 1.66, 95% CI = 1.00–2.77), or meeting STOPP (aOR = 1.07, 95% CI = 0.79–1.45) or START (aOR = 0.72; 95%CI = 0.50–1.06) criteria or the number of PIP/PPO criteria met was not significantly associated with ADR-related admissions. Patients prescribed certain drug classes (e.g., antiplatelet agents, diuretics) per individual PIP criteria were more likely to have an ADR-related admission. Conclusion: There was a high prevalence of PIP and PPOs in this cohort but no association with ADR-related admissions.
Anti-inflammatory and Antioxidant Activity of Cucumis sativus and Citrus macroptera Herbal Formulation: An In-Vitro Study

Background The interest in natural remedies is increasing rapidly as they can serve as alternatives to synthetic drugs and reduce their potential side effects. Current research is focused on examining the antioxidant and anti-inflammatory characteristics of a combination of Cucumis sativus and Citrus macroptera extract in an in-vitro context. The combination of citrus, cucumber, and glycerol extract could serve as an effective alternative to synthetic antioxidants and anti-inflammatory drugs and lower the side effects of the available synthetic drugs. This extract can be used to treat potentially malignant oral disorders like oral leukoplakia, oral submucous fibrosis, and oral lichen planus, which are attributed to its antioxidant properties. Aim To evaluate the anti-inflammatory and antioxidant activity of formulation of C. sativus, C. macroptera, and glycerol extract. Materials and methods The cucumber and citrus fruits were separated, cleaned, and dried. The cucumber was then peeled, its seeds cleaned, and the pulp cut into pieces. Using a laboratory mortar and pestle, a 5 ml extract was prepared. The citrus fruit was cut in half, its seeds were removed, and a 5 ml extract was prepared from their pulp only. These two extracts were combined to form a 10 ml extract solution with 8 ml of glycerol. The extracts were combined, shaken for 24 hours, filtered, and stored at 4°C. Assays like the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, Hydrogen Peroxide (H2O2) assay, Bovine serum albumin (BSA) assay, and Egg albumin (EA) denaturation assay were performed to assess their anti-inflammatory and antioxidant properties. Results The antioxidant and anti-inflammatory properties of the extract showed comparable activity (percentage of inhibition: 76% in BSA and EA assays; 90% in DPPH and H2O2 assays) to that of the standard values (percentage of inhibition: 78% in BSA and EA assays; 92% in DPPH and H2O2 assays) at concentrations 30, 40, and 50 µl in the BSA assay, EA assay, DPPH, and H2O2 assay. The maximum concentration at which the antioxidant and anti-inflammatory effects were appreciable was 50 µl in all assays. Conclusion This study concluded that the combination of cucumber, citrus, and glycerol extract could serve as an effective alternative to synthetic antioxidants and anti-inflammatory drugs currently available. These extracts can provide a promising solution in the field of drug development for treating lesions caused by free radicals and oxidative stress in the oral cavity.
Algorithmic Bias or Algorithmic Reconstruction? A Comparative Analysis Between AI News and Human News

Despite a substantial body of scholarship at the intersection of artificial intelligence (AI) and journalism, it remains relatively unexplored as to how AI-generated news is different from news produced by professional journalists in terms of news bias. To fill the gap, this study compares human versus GPT-2-generated news in terms of the linguistic features, tone, and bias toward gender and race/ethnicity on two highly controversial issues, namely abortion and immigration, using news transcripts from CNN and Fox News. In doing so, the study adopts a mixed-method content analysis approach, including dictionary and coreference analysis, topic modeling and semantic network analysis, and manual content analysis. The results reveal that although AI news differs from human news in terms of language features and thematic areas, machine news is not necessarily more biased compared to human news regarding gender and race/ethnicity. Implications are discussed for future scholarship on
Digital Commons @ East Tennessee State University Digital Commons @ East Tennessee State University

A master plan in higher education is developed to address the academic and workforce needs of a particular state. The master plan helps serve as the roadmap for implementation of proposed strategies to reach state goals in education and degree attainment. In Tennessee, Drive to 55 is a state-wide effort to increase the number of Tennesseans with a higher education credential to 55% by the year 2025. In an attempt to gain a deeper understanding of the key elements within state master plans, an independent review of ten state plans was conducted. The states involved in the analysis were Tennessee, Virginia, West Virginia, New York, Colorado, Arkansas, Nevada, Louisiana, Connecticut, and Massachusetts. The informal review revealed four key elements of state master plans in higher education: accessibility, affordability, accountability, and success. A consensus to reach underserved, underrepresented, or nontraditional students could be found among all ten states. Increasing accessibility to higher education can help abridge achievement gaps and eliminate disparities. Through responsible planning, management of resources, and assistance of those with demonstrated financial need, a quality higher education degree or credential that is affordable could be obtained. Accountability is measured in various ways by the ten states; however, clear expectations for performance are needed to ensure student success and positive institutional outcomes are experienced. A key element of success was noted to be college readiness and characteristics of students including determination and grit. Nine out of the ten states reviewed had some form of performance-based funding measures in place; providing incentives for institutions to help students successfully complete degree programs.
UvA-DARE (Digital Academic Repository) A numerical approach to evaluating the transient distribution of a quasi birth-death process

This paper considers a continuous-time quasi birth-death ( QBD ) process, which informally can be seen as a birth-death process of which the parameters are modulated by an external continuous-time Markov chain. The aim is to numerically approximate the time-dependent distribution of the resulting bivariate Markov process in an accurate and efficient way. An approach based on the Erlangization principle is proposed and formally justified. Its performance is investigated and compared with two existing approaches: one based on numerical evaluation of the matrix exponential underlying the QBD process, and one based on the uniformization technique. It is shown that in many settings the approach based on Erlangization is faster than the other approaches, while still being highly accurate. In the last part of the paper, we demonstrate the use of the developed technique in the context of the evaluation of the likelihood pertaining to a time series, which can then be optimized over its parameters to obtain the maximum likelihood estimator. More specifically, through a series of examples with simulated and real-life data, we show how it can be deployed in model selection problems that involve the choice between a QBD and its non-modulated counterpart.
Extracellular vesicles in the Chronic Myeloid Leukemia scenario: an update about the shuttling of disease markers and therapeutic molecules

Extracellular vesicles (EVs) are various sets of cell-derived membranous structures containing lipids, nucleic acids, and proteins secreted by both eukaryotic and prokaryotic cells. It is now well recognized that EVs are key intercellular communication mediators, allowing the functional transfer of bioactive chemicals from one cell to another in both healthy and pathological pathways. It is evident that the condition of the producer cells heavily influences the composition of EVs. Hence, phenotypic changes in the parent cells are mirrored in the design of the secreted EVs. As a result, EVs have been investigated for a wide range of medicinal and diagnostic uses in different hematological diseases. EVs have only recently been studied in the context of Chronic Myeloid Leukemia (CML), a blood malignancy defined by the chromosomal rearrangement t(9;22) and the fusion gene BCR-ABL1. The findings range from the impact on pathogenesis to the possible use of EVs as medicinal chemical carriers. This review aims to provide for the first time an update on our understanding of EVs as carriers of CML biomarkers for minimal residual disease monitoring, therapy response, and its management, as well as the limited reports on the use of EVs as therapeutic shuttles for innovative treatment approaches.
Enlarged colony housing promotes linear progression of subchondral bone remodeling in joint instability rat models

Objective: Osteoarthritis (OA) is a disease with high prevalence and an unmet medical need for disease modifying treatments. In rat models, OA-like subchondral bone and cartilage changes can be induced by instability surgery with different severity levels. Factors which determine structural changes additionally comprise the study duration and activity-impacted joint loading. Methods: A medial meniscal tear (MMT) or anterior cruciate ligament transection with partial meniscectomy (ACLT+pMx) was induced unilaterally in rats housed in a rat colony cage (RCC), allowing high activity levels including jumping and stair climbing. In parallel, ACLT+pMx rats were housed in Type IV cages. The time course of OA-related changes was investigated at 4, 8, 12, and 16 weeks after surgery by micro-CT, gait analysis and joint diameter measurements. Results: Gait disturbance was observed after 2 weeks and to a similar extend in all models. The increase in ipsilateral joint diameters peaked after 2 weeks and were more pronounced after ACLT+pMx compared to MMT-surgery, but independent of housing. Micro-CT analysis revealed that increases in osseous tibial width were most distinct after ACLT+pMx in RCC and progressed continuously until week sixteen. In contrast, osseous tibial width of ipsilateral joints in MMT RCC and ACLT+pMx Type IV groups did not increase further after week twelve. In contralateral joints, this parameter was not affected, regardless of the model or caging. However, a significant increase in bone volume fraction and trabecular thickness was observed over time in the femur and tibia of both ipsilateral and contralateral knees. Here, the medial tibial compartment of the operated joint was most affected and linear changes were most pronounced in the ACLT+pMx RCC group. Conclusion: Increased movement of animals in colony cages leads to robust structural changes in subchondral bone after surgically induced joint instability over time, while in regular Type IV housing maximal changes are reached in week twelve. The new insights into the differentiation of the models, particularly with respect to the linear progression of bone changes in ACLT+pMx in the RCC, may be useful for the design of chronic OA-studies within a longer lifespan and therefore supporting the development of novel therapies.