Miracle-dz/UniFAR-FTUs huggingface dataset:
Functionalized Gold Nanoparticles Suppress the Proliferation of Human Lung Alveolar Adenocarcinoma Cells by Deubiquitinating Enzymes Inhibition

Functionalized gold nanoparticles (AuNPs) are widely used in therapeutic applications, but little is known regarding the impact of their surface functionalization in the process of toxicity against cancer cells. This study investigates the anticancer effects of 5 nm spherical AuNPs functionalized with tannate, citrate, and PVP on deubiquitinating enzymes (DUBs) in human lung alveolar adenocarcinoma (A549) cells. Our findings show that functionalized AuNPs reduce the cell viability in a concentration- and time-dependent manner as measured by modified lactate dehydrogenase (mLDH) and 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assays. An increased generation of intracellular reactive oxygen species (ROS) and depletion of glutathione (GSH/GSSG) ratio was observed with the highest AuNP concentration of 10 μg/mL. The expression of DUBs such as ubiquitin specific proteases (USP7, USP8, and USP10) was slightly inhibited when treated with concentrations above 2.5 μg/mL. Moreover, functionalized AuNPs showed an inhibitory effect on protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) and wingless-related integration site (Wnt) signaling proteins, and this could further trigger mitochondrial related-apoptosis by the upregulation of caspase-3, caspase-9, and PARP in A549 cells. Furthermore, our study shows a mechanistic understanding of how functionalized AuNPs inhibit the DUBs, consequently suppressing cell proliferation, and can be modulated as an approach toward anticancer therapy. The study also warrants the need for future work to investigate the effect of functionalized AuNPs on DUB on other cancer cell lines both in vitro and in vivo.
Prevalence and Characteristics of Ascending Aorta Dilatation in Pediatric Patients with Bicuspid Aortic Valve and Aortic Valve Stenosis: A Cross-Sectional Analysis

Objective: We aim to examine the prevalence and characteristics of ascending aorta (AA) dilatation in pediatric patients, specifically focusing on its relationship with the bicuspid aortic valve (BAV) and aortic valve stenosis (AS). We also seek to identify potential risk factors and clinical implications of AA dilatation within this population. Materials and Methods: In this retrospective cross-sectional study, 71 pediatric patients who underwent echocardiography between 2010 and 2022 were analyzed. AA dilatation is seen in connective tissue disorders and in BAV. Our objective was to look at the potential diagnoses for pediatric AA dilatation, focusing on associated aortic valve diseases. Patients with genetic syndromes, congenital heart defects, or other cardiac conditions were excluded. Aortic measurements were taken using standard techniques, and z-scores were calculated. Statistical analyses were performed to evaluate associations between aortic dilatation, valvular conditions, and other variables. Results: The median age of 71 patients was 9 years (1 day–18 years). AA dilation was common in patients with AS (36%) and BAV (47%). Isolated aortic root dilation was observed in 49% of cases. AA z-scores were statistically higher in BAV patients (p=0.034), but no difference was found in aortic root z-scores be-tween BAV and non-BAV patients (p=0.117). AA z-scores correlated with aortic root z-scores and BAV presence (p=0.037, p=0.033). Patients with AS had smaller aortic root z-scores compared to those without AS (p=0.003). Smaller aortic root z-scores were also found in patients with both AS and BAV compared to those without either condition (p=0.0001). We could not find a statistically significant difference in AA dilatation in patients with and without AS. Conclusion: AA dilatation is a significant concern in pediatric patients with BAV, especially when AS is present. Routine echocardiography is essential for monitoring and early detection of aortic dilatation. Further studies are needed to understand the long-term implications and to optimize diagnostic approaches.
Matrix-Based Digital Calibration Technique for High-Performance SAR and Pipeline ADCs

A foreground matrix-based digital calibration technique is proposed for high-performance Nyquist analog-to-digital converters (ADCs) to reduce the performance loss due to transistor limitations and unavoidable converter component mismatches. A set of patterns is obtained during foreground calibration and then used during normal operation to correct the ADC output using conventional digital circuitry. This technique is validated through a 12-bit SAR ADC running at 350 MS/s and a test sinusoidal tone at 10 MHz that can be efficiently generated on-chip. The simulation results of the ADC including 2% random capacitive DAC (CDAC) array elements mismatch, employing the proposed calibration methods show 16.4/14.6 dB signal to distortion ratio (SNDR)/ spurious free dynamic range (SFDR) improvement, respectively. Besides, a significant improvement in both differential non-linearity (DNL) and integral non-linearity (INL). The proposed calibration technique is adopted to calibrate a fabricated 13-bit Pipeline ADC that operates at 260 MS/s, which achieves 68.23 dB and 85.82 dB SNDR/SFDR for low frequencies. When measured at 123.129 MHz, the ADC achieves 65.9/80 dB SNDR/SFDR, respectively. The chip was manufactured in TSMC 40-nm CMOS process.
Changes in transitional snowfall season length in northern Eurasia

An earlier study suggested that snow season length over large parts of northern Eurasia has increased due to earlier dates of first snowfall and later dates of last snowfall during 1937–94. In this study, much smaller increases in the length of continuous snow cover have been found over very limited areas of northern Eurasia, while decreases in continuous snow cover have been found over southern Siberia. The transitional snowfall season, defined by the difference between the first (last) snowfall date and the first (last) date of continuous ground snow cover, showed significant increases over much of Siberia. The increase in spring transitional snowfall season length is partly attributable to a later last snowfall date and partially due to earlier disappearance of continuous snow cover. The increase in fall transitional snowfall season length is mostly attributable to an earlier starting date of first snowfall.
A Bibliometric Analysis of Online Self-Disclosure Research

The online environment spreads a strong culture of self-disclosure by providing individuals with countless opportunities for social interaction. This spread has accelerated with the COVID-19 pandemic. As the culture of self-disclosure in the online environment increases, it is curious how families, students, and educators are affected by the situation. It is important for psychological counselors who are engaged in adaptive, preventive, and remedial work in schools to investigate the opportunities and risky aspects of online self-disclosure. It should be carefully examined to see how it will add innovations to counselors' practices. This study aims to present a publication profile on online self-disclosure through bibliometric analysis. In this context, only 256 articles published in English and Turkish related to education, psychology, and family were analyzed. According to the findings, the country with the highest number of publications on online self-disclosure was the USA. The most publishing institutions are universities in the USA. The most productive year on the subject was 2021. It was determined that more and more effective publications were made with adolescents. The most frequently repeated keyword is self-disclosure, while social disruption is the most frequently repeated keyword in terms of psychological factors. It can be said that online self-disclosure is in its infancy in both educational and psychological counseling literature.
The Combination of Energy Storage and Renewable Energies to Reach a Maximum Profit for Power Systems

This paper investigates the effectiveness of the water storage and electricity generation of a pumped-storage hydroelectric plant (PSP) for maximizing total electricity sale revenue of one day as it is integrated into a hybrid power system with the presence of wind power plants (WP) and solar photovoltaic power plants (SP). Four study cases with different rated powers of PSP, including 50, 75, 100 and 125 MW, are implemented to find the most suitable capacity, the optimal hours for water storage and the optimal generation for other hours of the considered PSP. Similarly, the four cases are also investigated for another hybrid power system with the same WP and SP, but PSP is replaced with another conventional hydroelectric plant (CHEP), which does not have a storage function. Five optimization algorithms, including Slime mould algorithm (SMA), Equilibrium optimizer (EO), Jellyfish Algorithm (JS), Coot optimization algorithm (COOT) and War Strategy optimization Algorithm (WSO), are implemented for two hybrid power systems. As a result, EO is the highest performance method with superiority over others in almost all cases. The second hybrid system with PSP can reach a greater revenue than the first hybrid system with CHEP by ${\$}31,638$ , which is about 11% of the total revenue of the first system. In addition, the second system only uses a PSP with a rated power of 75 MW, but the first system must use a higher rated power of 100 MW for CHEP. Clearly, PSP is very effective for hybrid power systems with the integration of renewable power plants in reaching maximum total revenue. However, the comparisons among study cases also indicate that the rated power of PSP should be carefully calculated, otherwise, PSP is no longer applicable.
PENGARUH ORIENTASI BELAJAR TERHADAP KINERJA INOVASI MELALUI INTEGRASI RANTAI PASOKAN PADA PERUSAHAAN FURNITURE ROTAN DI CIREBON

Penelitian ini bertujuan untuk mengetahui pengaruh Orientasi Belajar terhadap Kinerja Inovasi melalui Integrasi Rantai Pasokan pada perusahaan rotan di Cirebon. Penelitian ini menggunakan metode kuantitatif dengan jumlah responden sebanyak 127 responden dengan menggunakan metode purposive sampling. Pengujian hipotesis ini dilakukan dengan metode Structural Equation Model (SEM) dengan bantuan software AMOS. Hasil menunjukan bahwa Orientasi Belajar pengaruh positif terhadap Kinerja Inovasi, Orientasi Belajar pengaruh positif terhadap Integrasi Rantai Pasokan, dan Integrasi Rantai Pasokan pengaruh positif terhadap Kinerja Inovasi.
Hatchability and hatching time of Arab Chicken eggs With Different Heat Sources

This study was conducted to determine the hatchability and hatching time of Arab chicken eggs in incubators with different heat sources. The research was carried out at the Poultry Laboratory of the Faculty of Animal Science, University of Mataram. A total of three hundred fertile eggs were placed into two different types of incubators which were an electric incubator (EI) and an oil lamp heating incubator (OLHI). Each treatment was repeated three times (150 eggs/treatment). The data were analysed using the t-student test. The results showed that the fertility of Arab chicken eggs incubated using the electric incubator (EI) was 85.2% and OLHI incubator was 90.7%. Embryo viability at EI was 85.6% and OLHI was 90.5%. The hatchability of EI was 70.9% and OLHI was 83.8%, and the hatching weight of EI was 29.6 g, while the OLHI hatching machine was 28.9 g, and the hatching time of eggs on the EI incubator was 21.3 days and OLHI was 21.7 days. Different types of incubators had no significant effect (P>0,05) on the fertility of eggs, embryo viability, hatching time, and hatching weight but it had an effect (p=0.043) on the hatchability. In conclusion, the heat source of the kerosene lamp was better than that of an electric heating incubator
Stability of the Stationary Flow of an Incompressible Liquid

The work presents four methods for assessing the stability of stationary vortex structures in multiple continuous regions. First one is based on linearized Navier - Stokes equations using modal analysis. The second method considers non-linear equations and is focused on the stability of the stationary flow at the inner point of the region. The third method is focused on the qualitative analysis of the dependence of an input power, performance and dissipation function. The fourth method is based on the analysis of the potential energy of the flowing liquid. Each of the mentioned methods will be described by a mathematical model, from which it will be possible to assess the influence of boundary conditions and the shape of the area on the mentioned stability.
Basic Characteristics and Earthquake Risk Analysis of the Anning River Fault Zone in the West of Sichuan Province

On the basis of the image interpretation,geological investigation of the field by Quaternary mapping,sample collecting and difference GPS measuring of the surface etc.,We study the relationship between quaternary geomorphologic features in the Anninghe River Fault Zone.And the adjacent region and the activity of Anninghe Fault Zone.And we analyze the activity characteristics of the Anninghe River Fault Zone since Late Quaternary,and discuss the risk of strong earthquakes in the Anninghe River Fault Zone.The results show that the Anninghe River Fault Zone featured a strong left-lateral strike slip and thrust since the Late Quaternary.The Anninghe River Fault Zone can be divided into two parts;in the north segment,the last earthquake event may occurred around the 15th century AD,in the south segment,the last event may occurred in 1536 in Xichang City of Sichuan Province.The strong-earthquake risk in the north segment of the Anninghe River Fault Zone is higher than the one in the south segment and the future strong earthquake's magnitude will be 7.5 or so.
Determination of Tympanostomy Tube Types for Otitis Media with Effusion in Patients with Cleft Palate: Comparison between Paparella Type 1 and Type 2 Tubes

This study examined the effects of different types of tympanostomy tubes in pediatric patients undergoing cleft palate (CP) surgery in order to provide guidance for the proper insertion of tympanostomy tubes in the management of otitis media with effusion (OME). A total of 101 ears with middle ear effusion in 51 patients with CP were included in this study. Patients underwent palatoplasty and tympanostomy tube surgery at the same time. The type of tube inserted (Paparella type 1 or 2), the severity of CP, and types of palatoplasty surgeries were investigated. All patients were followed up for at least 6 months, and recurrence rates, complications, and reinsertion surgery were evaluated. The rate of OME recurrence after spontaneous tube extrusion was significantly higher in the type 1 group than in the type 2 group (44.3% vs. 19.4%, respectively, p = 0.016). Persistent eardrum perforation was more common in the type 2 group than in the type 1 group (41.9% vs. 12.9%, respectively, p = 0.001). The tube reinsertion rate was higher in the type 1 group than in the type 2 group (22.9% vs. 3.2%, respectively, p = 0.015). The tube reinsertion rate decreased to 8.6% in cases of palatoplasty with Sommerlad’s technique, even with type 1 tube insertion, which was not significantly different from the reinsertion rate in the type 2 group (3.7%, p = 0.439). The Paparella type 1 tube would be a better choice in cases of palatoplasty performed using Sommerlad’s technique, particularly considering the higher rate of persistent eardrum perforation after extrusion associated with the Paparella type 2 tube. Alternatively, a larger size type 2 tube may be considered in other surgeries to decrease the frequency of recurrence and tube reinsertion.
Simulation of the Effects of Geometry on Performance of Luminescent Solar Concentrator Photovoltaic Devices

This computational study presents the influences of device geometry, including shape, size, and thickness, on the performance of luminescent solar concentrator photovoltaic (LSC-PV) devices. LSC-PV device optical performance was simulated for 8 different device shapes: circular, regular triangular, pentagonal, hexagonal, square, and three rectangular with varying aspect ratios, with 10 different surface areas from 1 cm2 to 1 m2, and 10 different thicknesses from 0.2 to 5 cm; for 11 different concentrations, 10–110 parts per million (ppm), of 4 different organic dyes. Each of the LSC-PV devices employs monocrystalline silicon PV cells. The irradiance, as well as spectral distribution of irradiance received by the PV cells, has been simulated by means of Monte Carlo ray tracing to calculate the electrical power and power conversion efficiencies. The results show that triangles, pentagons, and hexagons have better optical performance than squares or circles. Furthermore, the optical internal loss of the LSC-PV device is positively correlated with the device size in which edge performance is relatively poor in larger size devices, and increasing lightguide thickness has a limited impact on the edge performance of the planar LSC-PV devices. Higher dye concentrations and greater stokes’ shifts of the dyes led to more significant edge emissions. The best performance of 3.24% was attained for 1-cm-thick, 100 cm2 small triangular units suitable for matrix-dense packing, using 110 ppm of LR305 dye with a high photoluminescence quantum yield (95%) and a relatively large stokes shift (29 nm).
8-Oxoguanine-DNA-Glycosylase Gene Polymorphism and the Effects of an Alternating Magnetic Field on the Sensitivity of Peripheral Blood.

BACKGROUND The production of reactive oxygen species (ROS) in animals and cells often results from exposure to low-intensity factors, including magnetic fields. Much of the discussion about the initiation of oxidative stress and the role of ROS and radicals in the effects of magnetic fields has centered on radical-induced DNA damage. METHODS The DNA concentration in the final solution was determined spectrophotometrically. Typing of the polymorphic variant rs1052133 of the 8-oxoguanin DNA glycosylase (hOGG1) gene was performed by polymerase chain reaction. An enzyme immunoassay was performed to determine the level of 8-oxyguanine in DNA. To process samples exposed to an alternating magnetic field, the authors developed a device for the automated study of biological fluids in an alternating magnetic field. The content of hydrogen peroxide in aqueous solutions of DNA was determined using the spectrophotometric method. RESULTS It was experimentally determined that an increase in the concentration of hydrogen peroxide in an aqueous medium by 3-5 times under the action of a low-frequency magnetic field reduces the resistance of the genomic material to oxidative modification and the accumulation of 8-oxyguanine in DNA. A model is proposed for the mechanism of action of a low-frequency magnetic field on aqueous solutions of nucleic acids and proteins, which satisfies the model of a chemical oscillator for the transformations of reactive oxygen species in an aqueous medium. The model illustrates the oscillating nature of the processes occurring in an aqueous solution of DNA and makes it possible to predict changes in the concentration of hydrogen peroxide in an aqueous solution of biopolymers, depending on the frequency of the acting low-intensity magnetic field. CONCLUSIONS The key element in the mechanisms involved in the effects of low-intensity magnetic field on living systems is the occurrence of ROS generation in the aquatic environment of chemical oscillators, in which the competition of physical and chemical processes (electron transfers, reactions of decay and addition of radicals, spin magnetically induced conversion, synthesis, and decay of the longest-lived form-hydrogen peroxide) is controlled by a magnetic field.
Antifungal analysis of incorporation of the essential oil of Cymbopogon citratus (D.C.) Stapf into polymethyl methacrylate

ABSTRACT Objective: Evaluated the antifungal effect of the incorporation of different concentrations of the essential oil Cymbopogon citratus (capim santo), into polymethylmethacrylate (PMMA) against Candida albicans. Methods: Fifty specimens were fabricated and divided into five groups: Group 1, PMMA + 10% essential oil (n=10); Group 2, PMMA + 15% essential oil (n=10); Group 3, PMMA + 20% essential oil (n=10); Group 4, PMMA + 25% essential oil (n=10); Group 5, PMMA (n=10). PMMA powder was mixed with the monomer and the mixture was placed in disc-shaped cavities measuring 15 mm in diameter, 2 mm thick. To evaluate the antifungal activity of the experimental specimens, the standard strain of Candida albicans was tested. After incubation, the colony count of each plate was performed using a digital colony counter, obtaining the number of colony forming units (CFU) and the Kruskal-Wallis test was applied. Results: There was statistically significant difference in the CFU count of Candida albicans as a consequence of the addition of Cymbopogon citratus essential oil to PMMA (p < 0.001) and values were significantly higher in comparison with those of all the other groups, when the essential oil was incorporated as incorporated into the PMMA in the concentration of 20%. In the other concentrations, no difference in values was observed in comparison with the Control Group without essential oil of Cymbopogon citratus. Conclusion: The acrylic resin with the essential oil incorporated into it in different concentrations provided no effect against development of the genus Candida.
To (Dis)agree with Automation: Effects of Automation Levels on Trust Attitude and Trust Behavior in High-Risk Situations

When automation takes over many functions and is highly reliable, humans often insufficiently monitor the correct system functioning. We investigated this phenomenon by introducing automation at the action implementation stage in two conditions: Participants working with monitored automation could veto the automation, whereas participants working with consensual automation had to agree with the automation. Based on neuropsychological research on cognitive dissonance, we expected that participants would devote more resources to checking the monitored automation compared to participants working with consensual automation, because the justification of a potential disagreement (veto) should be based on sufficient information. Additionally, we examined effects of risk on trust attitude and behavior when participants worked in virtual reality at either 0.5- or 70-meters altitude. We found a decrease in dissonance discomfort and an increase in self-reported trust across experimental blocks. At high risk, participants monitored automation significantly more. However, no main effects of automation were found.
Accounting and the exploitation of the natural world: Studies from a historical perspective

This article introduces the Special Issue of Accounting History on the topic of accounting and the exploitation of the natural world. After exploring the ambivalent nature of the word ‘exploitation’, with both positive and negative senses, the article reviews some earlier contributions to the historical accounting research literature relevant to the Special Issue. The four substantive research papers in the Special Issue are discussed and put into broader contexts, and the article identifies some potentially fruitful avenues for further research into how accounting has been implicated in the exploitation of the natural world in the past. The article concludes with brief tributes to two recently deceased accounting academics, Professor Tom Schneider and Professor Mike Jones, whose contributions to the Special Issue and to stimulating research into accounting for biodiversity, respectively, are acknowledged.