Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment With Liposomal Irinotecan Plus Fluorouracil and Leucovorin for Patients With Previously Treated Metastatic Biliary Tract Cancer: The Phase 2b NIFTY Randomized Clinical Trial.

Importance The NIFTY trial demonstrated the benefit of treatment with second-line liposomal irinotecan (nal-IRI) plus fluorouracil (FU) and leucovorin (LV) for patients with advanced biliary tract cancer (BTC). Objective To report the updated efficacy outcomes from the NIFTY trial with extended follow-up of 1.3 years with reperformed masked independent central review (MICR) with 3 newly invited radiologists. Design, Setting, and Participants The NIFTY trial was a randomized, multicenter, open-label, phase 2b clinical trial conducted between September 5, 2018, and December 31, 2021, at 5 tertiary referral centers in South Korea. Patients with advanced BTC whose disease progressed while receiving first-line gemcitabine plus cisplatin with at least 1 measurable lesion per Response Evaluation Criteria in Solid Tumors, version 1.1, were eligible. Data analysis was completed on May 9, 2022. Interventions Patients were randomized 1:1 to receive LV, 400 mg/m2, bolus and FU, 2400 mg/m2, for a 46-hour infusion intravenously every 2 weeks with or without nal-IRI, 70 mg/m2, before LV intravenously. Patients were treated until disease progression or unacceptable toxic effects. Main Outcomes and Measures Primary end point was progression-free survival (PFS) as assessed by MICR. Secondary end points were PFS as assessed by the investigator, overall survival, and objective response rate. Results A total of 178 patients (75 women [42.1%]; median [IQR] age, 64 [38-84] years) were randomly assigned, and 174 patients were included in the full analysis set (88 patients [50.6%] in the nal-IRI plus FU/LV group vs 86 patients [49.4%] in the FU/LV alone group). In this updated analysis, the median MICR-assessed PFS was 4.2 months (95% CI, 2.8-5.3) for the nal-IRI plus FU/LV group and 1.7 months (95% CI, 1.4-2.6) for the FU/LV alone group (hazard ratio, 0.61; 95% CI, 0.44-0.86; P = .004), in contrast to the 7.1 and 1.4 months reported in the previous study, respectively. The discordance rate for tumor progression date between the MICR and investigators was 17.8% (vs 30% in the previous study). Conclusions and Relevance The NIFTY randomized clinical trial demonstrated significant improvement in PFS with treatment with nal-IRI plus FU/LV compared with FU/LV alone for patients with advanced BTC after progression to gemcitabine plus cisplatin. The combination of nal-IRI plus FU/LV could be considered as a second-line treatment option for patients with previously treated advanced BTC. Trial Registration clinicaltrials.gov Identifier: NCT03524508.
New Modelling of Modified Two Dimensional Fisherface Based Feature Extraction

Biometric researches have been interesting field for many researches included facial recognition. Crucial process of facial recognition is feature extraction. One Dimensional Linear Discriminant Analysis is one of feature extraction method is development of Principal Component Analysis mostly used by researches. But, it has limitation, it can efficiently work when number of training sets greater or equal than number of dimensions of image training set. This limitation has been overcome by using Two Dimensional Linear Discriminant Analysis. However, search value of matrix identity R and L by using Two Dimensional Linear Discriminant Analysis takes high cost, which is O(n 3 ). In this research, the seeking of “Scatter between Class” and “Scatter within Class” by using Discriminant Analysis without having to find the value of R and L advance are proposed. Time complexity of proposed method is O(n 2 ). Proposed method has been tested by using AT&T face image database. The experimental results show that maximum recognition rate of proposed method is 100%.
Enterohemorrhagic Escherichia coli responds to gut microbiota metabolites by altering metabolism and activating stress responses

ABSTRACT Enterohemorrhagic Escherichia coli (EHEC) is a major cause of severe bloody diarrhea, with potentially lethal complications, such as hemolytic uremic syndrome. In humans, EHEC colonizes the colon, which is also home to a diverse community of trillions of microbes known as the gut microbiota. Although these microbes and the metabolites that they produce represent an important component of EHEC’s ecological niche, little is known about how EHEC senses and responds to the presence of gut microbiota metabolites. In this study, we used a combined RNA-Seq and Tn-Seq approach to characterize EHEC’s response to metabolites from an in vitro culture of 33 human gut microbiota isolates (MET-1), previously demonstrated to effectively resolve recurrent Clostridioides difficile infection in human patients. Collectively, the results revealed that EHEC adjusts to growth in the presence of microbiota metabolites in two major ways: by altering its metabolism and by activating stress responses. Metabolic adaptations to the presence of microbiota metabolites included increased expression of systems for maintaining redox balance and decreased expression of biotin biosynthesis genes, reflecting the high levels of biotin released by the microbiota into the culture medium. In addition, numerous genes related to envelope and oxidative stress responses (including cpxP, spy, soxS, yhcN, and bhsA) were upregulated during EHEC growth in a medium containing microbiota metabolites. Together, these results provide insight into the molecular mechanisms by which pathogens adapt to the presence of competing microbes in the host environment, which ultimately may enable the development of therapies to enhance colonization resistance and prevent infection.
Increasing Primary Care Utilization of Medication-Assisted Treatment (MAT) for Opioid Use Disorder

Background: With increasing prevalence of opioid use disorders (OUDs) there is an urgent need for OUD trained front line primary care providers (PCPs) who can help improve patient adherence to addiction treatment. Unfortunately, most physicians have had limited training for treating patients with addiction, leaving clinicians under prepared. To address this need, we created a Medication-Assisted Treatment (MAT) training program specifically designed for PCPs. Intervention: A 4-hour PCP focused buprenorphine office-based implementation training was designed to supplement the 8-hour SAMHSA DATA 2000 waiver training. The intent of the supplemental training is to increase PCP likelihood of implementing MAT through practical evidenced-based implementation, addressing barriers reported by waivered PCPs. Methods: We developed and validated a new pre- and postsurvey instrument that assesses changes in participants knowledge, skills, and attitudes. Data were entered into REDCap, and composite scales were created and analyzed to determine pre–post differences. Results: A total of 183 participants completed pre–post evaluations. Pre–post comparisons indicated substantial improvement in learner levels of confidence in implementing MAT care processes and in their interactions with MAT patients (df = 4, F = 203.518, P < .001). Participants described themselves as more comfortable identifying patients who would benefit from MAT (t = 15.04, P < .001), more competent in implementing MAT (t = 21.27, P < .001) and more willing (t = 15.56, P < .001) to implement MAT after training. Conclusion: Evidence suggests that a new MAT training program that supplements the SAMHSA waiver training increases confidence and willingness to implement MAT among PCPs. Efforts to replicate this success to allow for further generalization and policy recommendations are warranted.
A critical review of ustekinumab for the treatment of active ulcerative colitis in adults

ABSTRACT Introduction Ustekinumab is a humanized monoclonal antibody, targeting the p40 subunit common to both human interleukin 12 and 23, approved by the European Medicines Agency and US Food and Drug Administration for the treatment of moderate-to-severe ulcerative colitis. Areas covered In this review, the results of the phase 3 UNIFI and the real-world studies assessing the efficacy and safety of ustekinumab in moderate-to-severe ulcerative colitis are discussed, as well as limitations of these studies. Predictive factors of response, the interest of therapeutic drug monitoring and the positioning of ustekinumab in specific situations are also addressed. Finally, in the light of data presented, the positioning of ustekinumab in the therapeutic algorithm of ulcerative colitis will also be considered. Expert opinion Ustekinumab has been shown to be effective to induce and maintain clinical, endoscopic and histologic remission in moderate-to-severe ulcerative colitis both in phase 3 and real-world studies, with a favorable safety profile. Overall, its favorable risk–benefit ratio, its efficacy on extra-intestinal manifestations and in biologics failure patients make ustekinumab an ideal candidate as first, second, or third-line therapy in ulcerative colitis.
CARACTERIZACION DE LAS EVOLUTAS DE CURVAS PLANAS Characterization of the evolutes of planes curves

In this article three forms appear to determine evo lute of a plane curve. The first form consists of defining fields of Jacobi througho ut a normal straight line to plane curve end evolute will be the geometric place where these fields are annulled. Second it consists of using some results of the contact theory and singularities, that is to say the set formed by the points is verified that are center of circles that contact of order 3 has with plane c urve is the evolute of this curve. Finally evolute is determined of like the surroundi ng of normal straight lines the plane curve.
Dimensional analysis of windscreen noise

It is shown that data on wind noise in spherical and cylindrical windscreens may be represented by a single universal curve if the data are plotted in nondimensional form. Appropriate dimensionless variables are a dimensionless frequency ( fD/V) plotted against a sound pressure coefficient (p1/3/ρV2) or a dimensionless spectral density fS/ρ2V4), where f is frequency, D is screen diameter, V is wind speed, p1/3 is sound pressure of the wind noise in a 1/3‐octave band, ρ is fluid density, and S is spectral density of the wind noise at frequency f. Data obtained from various disparate sources form a single curve with surprisingly small scatter for values of dimensionless frequency ( fD/V) up to 5.
Duchenne cardiomyopathy: targeting ROS and NOX4 as a promising therapeutic strategy

Duchenne muscular dystrophy (DMD; OMIM#310200) is a pediatric muscle disorder, affecting approximately 1 in every 5000 male births worldwide [1]. DMD is caused by mutations in the X-linked DMD gene, resulting in the absence of the functional form of its major protein product Dystrophin. The absence of Dystrophin results in several detrimental downstream effects, such as disruption of calcium (Ca) homeostasis, oxidative stress, inflammation, and mitochondrial dysfunction. Ultimately, these impairments make cardiac myocytes extremely vulnerable for degeneration, necrosis and thereby contributing to the progressive phase of cardiac fibrosis (Reviewed by [2]). Adverse myocardial remodeling and chronic cardiomyopathy are major causes of morbidity and early mortality of most DMD patients. Initially, left ventricular (LV) dilation and hypertrophy develop to cope with the higher muscle wall stress, induced by pressure/volume overload. Subsequently, rhythm abnormalities (mainly supraventricular arrhythmias) and remodeling of the heart architecture occur that progress to dilated cardiomyopathy (DCM). In particular, repetitive mechanical stress causes apoptosis and myocardial fibrotic deposition. Eventually, heart failure and arrhythmias will develop as the disease progresses (Reviewed by [3]). Here, we focus on the increased oxidative stress as a major contributor to the development and progression of heart failure and more specifically in Duchenne cardiomyopathy.
Triple‐combination clindamycin phosphate 1.2%/benzoyl peroxide 3.1%/adapalene 0.15% gel for moderate‐to‐severe acne in children and adolescents: Randomized phase 2 study

Topical clindamycin phosphate 1.2%/benzoyl peroxide 3.1%/adapalene 0.15% gel (IDP‐126) is the first fixed‐dose triple‐combination formulation in development for acne. This post hoc analysis investigated efficacy and safety of IDP‐126 in children and adolescents with moderate‐to‐severe acne.
An Efficient Feedback Coding Scheme With Low Error Probability for Discrete Memoryless Channels

Existing fixed-length feedback communication schemes are either specialized to particular channels (Schalkwijk-Kailath, Horstein), or apply to general channels but either have high coding complexity (block feedback schemes) or are difficult to analyze (posterior matching). This paper introduces a new fixed-length feedback coding scheme which achieves the capacity for all discrete memoryless channels, has an error exponent that approaches the sphere packing bound as the rate approaches the capacity, and has O(n log n) coding complexity. These benefits are achieved by judiciously combining features from previous schemes with new randomization technique and encoding/decoding rule. These new features make the analysis of the error probability for the new scheme easier than for posterior matching.
A Particle-Path based Method for Monte Carlo Density Estimation

Radiosity computation on scenes including objects with a complex geometry, or with a large number of faces and meshes with very different sizes, is very complex. We present a new method (based on the photon maps method 6 ) where density estimation on the tangent plane at each surface point is performed for irradiance computation by using photon paths instead of photon impacts. Other density estimation techniques require locally simple and flat surfaces in order to be able to compute approximations to irradiance. This requirement is not present in this method, because it does not use photon impacts. Thus we claim the algorithm is more independent of geometry. The algorithm requires fast ray-disc intersection tests, so we propose techniques for speeding up this part of the process. We compare this approach with the photon map technique, both qualitatively (in terms of its ability to handle complex geometry), and quantitatively (in terms of time and storage complexity). We obtained results which show that better images are obtained with some extra cost both in time and memory.
Increasing the Impact of Program Evaluation: The Importance of Challenging Assumptions and Incorporating New Perspectives

These remarks, which were given as the 2022 Recipient of the Peter H. Rossi Award for Contributions to the Theory or Practice of Program Evaluation, emphasize ways to increase the impact of program evaluation. First, is the importance of asking good questions, including ones that challenge the assumptions and models that dominate the field. Relatedly, we need to question the assumption that “one size fits all” and recognize the variation that exists—across contexts, time, and individuals. The key question is what works for whom under what conditions, and this also pushes us to think about why effects differ and what is driving those differences, that is, the underlying mechanisms. It is also important to incorporate new perspectives to improve our questions, models, research design, and interpretation, thus helping to address the aforementioned points. We should both welcome diverse perspectives into the research community and listen carefully to the communities we seek to study and incorporating their insights. Although the examples focus on a career in education research, the implications of the points are relevant for any aspect of social policy.
Investigation of Ultrasonic Emulsifying Processes of a Linseed Oil and Water Mixture

Ultrasonic emulsifying processes of immiscible liquids can be used to obtain stable emulsions. The authors used an ultrasonic sandwich head with an energy concentrator to obtain a suitable value of the energy density necessary for the emerge of ultrasonic cavitation. Two piezoelectric ring (Dext = 50 mm) transducers of Pz-26 type produced by FERROPERM were used to design the ultrasonic sandwich head. The frequency of the ultrasonic wave was 18.4 kHz and the excitation time of the ultrasonic transducer exiting 5 minutes. Visible bubbles during the generation of ultrasonic waves appeared in the mixture after exceeding the cavitation threshold. The authors determined also the cavitation threshold by measuring the electrical voltage conducted to the transducers. To receive long-lasting emulsion, the electrical voltage attained 300 Vpeak. The dispersion dependence on the emulsifying time was determined. The emulsion of linseed oil and water was stable through some months without surfactants.
A computational approach for the identification of distant homologs of bacterial riboswitches based on inverse RNA folding

Riboswitches are conserved structural ribonucleic acid (RNA) sensors that are mainly found to regulate a large number of genes/operons in bacteria. Presently, >50 bacterial riboswitch classes have been discovered, but only the thiamine pyrophosphate riboswitch class is detected in a few eukaryotes like fungi, plants and algae. One of the most important challenges in riboswitch research is to discover existing riboswitch classes in eukaryotes and to understand the evolution of bacterial riboswitches. However, traditional search methods for riboswitch detection have failed to detect eukaryotic riboswitches besides just one class and any distant structural homologs of riboswitches. We developed a novel approach based on inverse RNA folding that attempts to find sequences that match the shape of the target structure with minimal sequence conservation based on key nucleotides that interact directly with the ligand. Then, to support our matched candidates, we expanded the results into a covariance model representing similar sequences preserving the structure. Our method transforms a structure-based search into a sequence-based search that considers the conservation of secondary structure shape and ligand-binding residues. This method enables us to identify a potential structural candidate in fungi that could be the distant homolog of bacterial purine riboswitches. Further, phylogenomic analysis and evolutionary distribution of this structural candidate indicate that the most likely point of origin of this structural candidate in these organisms is associated with the loss of traditional purine riboswitches. The computational approach could be applicable to other domains and problems in RNA research.
Action Observation Training to Improve Upper Limb Function in Infants with Unilateral Brain Lesion – a Feasibility Study

ABSTRACT In this study, the feasibility of Action Observation Training (AOT) in combination with sensor-based measurements in infants at high risk of Unilateral Spastic Cerebral Palsy (UCP) were evaluated. Over a four-week period, eight infants at high risk of UCP performed AOT at home while wearing sensors with assistance of caregivers. Sensor data were compared to clinical assessments of upper limb function, the Hand Assessment for Infants (HAI) and the Mini-Assisting Hand Assessment (Mini-AHA). AOT training time and acceptance by the caregivers were considered as indicators for feasibility. The excellent training adherence and positive feedback of the caregivers showed that the AOT was feasible in this patient group and setting. Sensor measurements were accepted and displayed significant correlations with hand function. These preliminary results indicate the potential of wearable sensors to record upper limb function over the course of AOT for infants at high risk of UCP. Thus, AOT in combination with sensor measurements are proposed as a feasible training tool to complement usual care.
Correlation and efficacy of TACE combined with lenvatinib plus PD‐1 inhibitor in the treatment of hepatocellular carcinoma with portal vein tumor thrombus based on immunological features

Although the appearance of portal vein tumor thrombus (PVTT) is significantly associated with unfavorable prognosis, there is insufficient evidence to confirm the efficacy and safety of the triple combination of transarterial chemoembolization (TACE), lenvatinib, and programmed cell death‐1 (PD‐1) inhibitor for patients with hepatocellular carcinoma (HCC) and PVTT. Furthermore, it remains unclear which patient type can obtain the best survival benefit from this combination therapy.
Finite element modeling of CMUTs using a perfectly matched layer for fast simulation

Capacitative micromachined ultrasonic transducer (CMUT) cells generate plate waves within the substrate on which they are constructed. Analysis of CMUT cells using finite element simulation requires a solid model with an absorbing boundary for elimination of plate wave reflections from the model boundary. Although this method performs well for eliminating the reflections, it significantly increases the mesh size and hence the simulation time. An observation on the nature of the plate wave modes generated by a CMUT cell shows that more than 97% of the outgoing power is carried in the lowest order anti-symmetric (A/sub 0/) Lamb wave mode. In this paper, a perfectly matched layer for the termination of the A/sub 0/ mode is proposed. Boundary elements tuned for the A/sub 0/ mode, reduce the reflected wave amplitude to -6 dB of the incident wave amplitude for operation frequencies up to 5 MHz. For a particular simulation model with 17,000 nodes, the proposed boundary elements reduce the mesh size by 30%.
Spacecraft Coating-Induced Charging: Materials and Modeling Study of Environmental Extremes

AU = astronomical unit 1:496 10 km b1, b2 = secondary electron range magnitudes _ D, _ Dphoton = electron and photon dose rates E0 = activation energy related to trap energy depth below the conduction band edge Emax = energy at which maximum secondary emission max occurs E inc = incident electron energy J emit = emitted current due to backscattered electron emission J inc, J ions inc = incident electron and ion currents J emit, J photo emit = emitted current due to ion-induced and photoninduced secondary electron emission J emit = emitted current due to electron-induced secondary electron emission Jnet = net current kRIC = radiation-induced conductivity proportionality constant n1, n2 = secondary electron range exponents ne = electron number density qe = magnitude of electron charge R, Rphoton = incident electron and photon ranges RJ = radius of Jupiter 6:991 10 km RS = radius of the sun 6:960 10 km r = heliocentric distance from the sun T = temperature Te, Tp = electron and proton temperatures Teff = effective plasma temperature Y eh = electron-hole pairs created per absorbed photon S="IR = solar absorptivity-to-infrared emissivity ratio max = maximum secondary electron yield = radiation-induced conductivity exponent "r = relative dielectric constant
The Turbulent Wall Jet Measurements and Modeling

The turbulent wall jet, even limiting attention to the topographically simple cases beloved of academics, arguably provides more puzzles for those seeking an ordered set of rules to describe turbulence than any other class of turbulent shear layer. Formally, we can regard a wall jet as a boundary layer in which, by virtue of the initially supplied momentum, the velocity over some region in the shear layer exceeds that in the free stream. Wall jets are of great and diverse engineering importance. While some of the best known and most challenging applications lie in the field of advanced airfoil design, these aerodynamic roles are far outweighed in number and, probably, in economic importance by the use of wall jets in problems of heating, cooling or ventilating-areas where traditionally design has proceeded unfettered by any deep concern about the turbu­ lence structure of the flows in question. Two major industrial applications are the film-cooling of the lining walls of gas-turbine combustion chambers and of the leading stages of