Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Feminist Movements and Activism in Challenging and Transforming Oppressive Structures and Systems in Different Contexts and Cultures in South Africa

Purpose: The aim of the study was to investigate the role of feminist movements and activism in challenging and transforming oppressive structures and systems in different contexts and cultures. Methodology: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries. Findings: Feminist movements and activism have been pivotal in challenging and transforming oppressive structures and systems globally. Through grassroots organizing, advocacy, and awareness campaigns, feminists have fought against patriarchal norms, gender-based violence, and discriminatory laws. Their efforts have contributed to significant legal reforms, cultural shifts, and increased representation of women in leadership roles. Across diverse contexts and cultures, feminist movements continue to push for gender equality, social justice, and the dismantling of oppressive structures. Unique Contribution to Theory, Practice and Policy: Intersectionality theory, postcolonial feminist theory & transformative feminist activism may be used to anchor future studies on the role of feminist movements and activism in challenging and transforming oppressive structures and systems in different contexts and cultures. Apply machine learning and dimension reduction techniques to genomic data to advance the field of precision medicine. Formulate policies and regulations that address privacy and ethical concerns when dealing with sensitive data, such as genomic information and personal text data
Reimagining Radiology: A Comprehensive Overview of Reviews at the Intersection of Mobile and Domiciliary Radiology over the Last Five Years

(Background) Domiciliary radiology, which originated in pioneering studies in 1958, has transformed healthcare, particularly during the COVID-19 pandemic, through advancements such as miniaturization and digitization. This evolution, driven by the synergy of advanced technologies and robust data networks, reshapes the intersection of domiciliary radiology and mobile technology in healthcare delivery. (Objective) The objective of this study is to overview the reviews in this field with reference to the last five years to face the state of development and integration of this practice in the health domain. (Methods) A review was conducted on PubMed and Scopus, applying a standard checklist and a qualification process. The outcome detected 21 studies. (Key Content and Findings) The exploration of mobile and domiciliary radiology unveils a compelling and optimistic perspective. Notable strides in this dynamic field include the integration of Artificial Intelligence (AI), revolutionary applications in telemedicine, and the educational potential of mobile devices. Post-COVID-19, telemedicine advances and the influential role of AI in pediatric radiology signify significant progress. Mobile mammography units emerge as a solution for underserved women, highlighting the crucial importance of early breast cancer detection. The investigation into domiciliary radiology, especially with mobile X-ray equipment, points toward a promising frontier, prompting in-depth research for comprehensive insights into its potential benefits for diverse populations. The study also identifies limitations and suggests future exploration in various domains of mobile and domiciliary radiology. A key recommendation stresses the strategic prioritization of multi-domain technology assessment initiatives, with scientific societies’ endorsement, emphasizing regulatory considerations for responsible and ethical technology integration in healthcare practices. The broader landscape of technology assessment should aim to be innovative, ethical, and aligned with societal needs and regulatory standards. (Conclusions) The dynamic state of the field is evident, with active exploration of new frontiers. This overview also provides a roadmap, urging scholars, industry players, and regulators to collectively contribute to the further integration of this technology in the health domain.
Development of a Hyperspectral sensor system for model-based remote water constituent inference

This project undertook a model-based inversion of spectral data for remote sensing of water constituents, from satellite based hyperspectral sensors. As the atmosphere effects dominate the observed spectrum, a parameterised model is needed for both the atmosphere, the water/atmosphere interface and the water itself. In order to calibrate these models, a sensor was developed for recording hyperspectral data. This sensor is portable and lightweight so that is can be used to simultaneously gather downwelling irradiance, as well as upwelling irradiance from a boat or other mobile platform during a HICO satellite sensor observation. We present data from apparatus deploying this sensor and perform model based inference on this data, as well as data from the HICO system.
Effect of Phosphate Solubilizing Microorganisms (PSM) on growth of Mentha spicata L.

The use of phosphate solubilizing microorganisms (PSM) as live microbial biofertilizers provides a promising alternative to chemical fertilizers. In the present study the effect of various doses of PSM culture on growth of spearmint ( Mentha spicata L.) plants were observed.A series of experiments were conducted in pot cultures in randomised block design (RBD). A commercial consortium of Bacillus megaterium, Pseudomonas putida and Aspergillus awamori was used as the PSM culture. The various growth parameters such as Fresh and dry weight, chlorophyll content, Nitrogen content, Phosphate Phosphorous content and potassium content of spearmint were tested after 60, 90 and 120 DAS. The results were encouraging and demonstrated significantly positive effect of increasing doses of PSM culture on various growth parameters of spearmint plants throughout the experiment. Amongst the various treatments, the treatment T 3 (0.03gm PSM culture per Kg sterilized soil) proved to be better for harvest at 90 DAS than the remaining treatments.
Acute Cytomegalovirus Colitis Presenting As Exacerbation of Ulcerative Colitis: A Case Report

This case report presents a 24-year-old female with a history of ulcerative colitis (UC) who sought care for symptoms initially suggestive of the disease exacerbation but was later diagnosed as acute cytomegalovirus (CMV) colitis. The patient's clinical course, marked by watery diarrhea, blood in stools, vomiting, and fever, raised suspicion of a UC flare. However, a nuanced diagnostic approach revealed CMV superinfection, including computed tomography, colonoscopy, and tissue polymerase chain reaction (PCR). The patient's immunosuppressive history, with prior treatment, including intravenous infliximab and azathioprine, contributed to CMV infection. Treatment involved initiation of tofacitinib and antiviral therapy with valganciclovir. This case underscores the diagnostic challenges in distinguishing between infectious complications and UC exacerbations, necessitating a tailored, multidisciplinary approach for optimal management. It highlights the delicate balance required when managing UC patients on immunosuppressive regimens, emphasizing the importance of timely diagnosis and individualized treatment strategies in complex clinical scenarios.
Transcriptomic Responses to Koi Herpesvirus in Isolated Blood Leukocytes from Infected Common Carp

Koi herpesvirus (KHV, CyHV-3) causes severe economic losses in carp farms. Its eradication is challenging due to the establishment of latency in blood leukocytes and other tissues. To understand the molecular mechanisms leading to KHV infection in leukocytes, common carp were bath-exposed to KHV at 17 °C. After confirming the presence of viral transcripts in blood leukocytes at ten days post infection, RNA-Seq was performed on peripheral blood leukocytes on the Illumina NovaSeq. KHV infection triggered a robust immune response mediated by pattern recognition receptors, mainly toll-like receptors (tlr2, tlr5, tlr7, and tlr13), urokinase plasminogen activator surface receptor-like, galectin proteins, and lipid mediators such as leukotriene B4 receptor 1. Enriched pathways showed increased mitochondria oxidative phosphorylation and the activation of signalling pathways such as mitogen-activated protein kinases (MAPKs) and vascular endothelial growth factor (VEGF). KHV-infected leukocytes showed low production of reactive oxygen species (ROS) and glutathione metabolism, high iron export and phagocytosis activity, and low autophagy. Macrophage polarization was deduced from the up-regulation of genes such as arginase non-hepatic 1-like, macrophage mannose receptor-1, crem, il-10, and il-13 receptors, while markers for cytotoxic T cells were observed to be down-regulated. Further work is required to characterise these leukocyte subsets and the molecular events leading to KHV latency in blood leukocytes.
Use of the Proboscis Extension Response Assay to Evaluate the Mechanism of House Fly Behavioral Resistance to Imidacloprid

Simple Summary This study investigated the detection and discrimination of the neonicotinoid insecticide imidacloprid by behaviorally resistant and susceptible house flies (Musca domestica L.). Flies were allowed to contact a sucrose solution containing either a low or a high concentration of imidacloprid with their tarsi alone or with both their tarsi and proboscis. The proboscis extension response (PER) for each house fly was recorded at 0, 2, and 10 s following the start of tarsal contact with the test solution. Following proboscis contact with the sucrose solution containing a high concentration of imidacloprid, behaviorally resistant flies had a significant reduction in PER (within 2 s), while imidacloprid-susceptible flies showed no differences in PER associated with the concentration of imidacloprid. When only the tarsi were allowed to contact either solution, there were no significant differences in PER observed for either fly strain (resistant or susceptible). These results suggest that behaviorally resistant house flies detect imidacloprid and can discriminate among low and high concentrations following proboscis contact but not tarsal contact with a sucrose solution containing imidacloprid. Understanding the mechanisms responsible for behavioral resistance to insecticides by the house fly is critical for creating sustainable pest management strategies for this fly. Abstract The house fly, Musca domestica L. , is a significant human and livestock pest. Experiments used female adult house flies glued onto toothpicks for controlled exposure of their tarsi alone (tarsal assay) or their tarsi and proboscis (proboscis assay) with a sucrose solution containing imidacloprid at either a low (10 µg/mL) or high (4000 µg/mL) concentration. Proboscis extension response (PER) assays were used to characterize the response of imidacloprid-susceptible and behaviorally resistant house fly strains to contact with sucrose solutions containing either a low or high concentration of imidacloprid. In each assay, 150 female flies from each fly strain were individually exposed to sucrose solutions containing either a low or high concentration of imidacloprid by deliberate contact of the fly tarsi to the test solution. The PER for each fly was subsequently recorded at 0, 2, and 10 s following the initial tarsal contact. A significant and rapid reduction in PER was observed only for the behaviorally resistant fly strain and only following contact by the flies’ proboscis with the sucrose solution containing the high imidacloprid concentration. The results suggest that chemoreceptors on the fly labellum or internally on the pharyngeal taste organs are involved in the detection of imidacloprid and discrimination of the concentration, resulting in an avoidance behavior (proboscis retraction) only when imidacloprid is at sufficient concentration. Further research is needed to identify the specific receptor(s) responsible for imidacloprid detection.
Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies

Worldwide urbanization and subsequent migration have accelerated the emergence and spread of diverse novel human diseases. Among them, diseases caused by viruses could result in epidemics, typified by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which hit the globe towards the end of December 2019. The global battle against SARS-CoV-2 has reignited interest in finding alternative treatments for viral infections. The marine world offers a large repository of diverse and unique bioactive compounds. Over the years, many antiviral compounds from marine organisms have been isolated and tested in vitro and in vivo. However, given the increasing need for alternative treatment, in silico analysis appears to provide a time- and cost-effective approach to identifying the potential antiviral compounds from the vast pool of natural metabolites isolated from marine organisms. In this perspective review, we discuss marine-derived bioactive metabolites as potential therapeutics for all known disease-causing viruses including the SARS-CoV-2. We demonstrate the efficacy of marine-derived bioactive metabolites in the context of various antiviral activities and their in silico, in vitro, and in vivo capacities.
Modeling the Recent Changes in the Arctic Ocean CO2 Sink (2006–2013)

The Arctic Ocean (AO) and its associated marginal seas have recently experienced rapid climate and environmental changes, most notably sea‐ice area (SIA) loss and warming potentially impacting its uptake of carbon dioxide (CO2). We used the state‐of‐the‐art ECCO2‐Darwin coupled ocean‐biogeochemistry model to simulate the 2006–2013 period and investigate the impact of changing SIA on the CO2 uptake of the AO. We find that the mean annual CO2 sink of the AO is 153 ± 14 TgC a−1 and the CO2 sink decreased at a rate of 3.6 TgC a−1 even though SIA decreased by 8 × 104 km2 a−1 over the same period. Extreme SIA loss in 2007 resulted in a 185.4 TgC CO2 sink, an increase ∼20% over the 2006–2013 mean. In contrast, extreme SIA loss of 2012 resulted in a CO2 sink of the AO of only 146.3 TgC due to two main factors: (1) increased both wind speed and stratification in the Eastern Siberian Sea absorbing less CO2 and (2) decreased primary production and area of air‐sea gas exchange in the Chukchi and Nordic Seas. Our model captures a trend of decreasing CO2 sink in most of the Chukchi Sea during fall but does not show the changes in winter CO2 sink in the Nordic and Barents Seas as previous independent studies have suggested. Our results indicate that future AO‐atmosphere CO2 exchange will be determined by complex interplay of SIA and other environmental drivers.
Calculations of the Radiation Dose for the Maximum Hormesis Effect

To date, the radiation-adaptive response has been reported as a low-dose-related phenomenon and has been associated with radiation hormesis. Well-known cancers are caused by non-radiation active reactants, in addition to radiation. A model of suppression for radiation-specific cancers was previously reported, but the model did not target radiation-nonspecific cancers. In this paper, we describe kinetic models of radiation-induced suppressors for general radiation non-specific cancers, estimating the dose M that induces the maximum hormesis effect while satisfying the condition that the risk is approximately proportional to a dose above NOAEL (No Observed Adverse Effect Level). The radiation hormesis effect is maximal when the rate constant for generation of a risk-reducing factor is the same as the rate constant for its decomposition. When the two rate constants are different, the dose M at which the radiation hormesis effect is maximized depends on both rate constants, but the dose M increases as the two rate constants approach each other, reaching a maximum dose. The theory proposed in this paper can only explain existing experiments with extremely short error bar lengths. This theory may lead to the discovery of unknown risk-reducing factor at low doses and the development of risk-reducing methods in the future.
Comparative study between 0.5% bupivacaine versus 0.5% ropivacaine in peribulbar anesthesia for cataract surgery

Background: For intraocular surgery, the optimal local anesthetic agent must have a rapid onset of action and a sufficient duration of effect so as to enable a painless, motionless procedure without prolonging akinesia. Aims and Objective: This prospective, comparative observational study compares ropivacaine and 0.5% bupivacaine for cataract surgery peribulbar block. Hyaluronidase is utilized in both groups because it promotes local anesthetic diffusion. Material and Methods: Present prospective, observational, comparative study performed at the Department of Anesthesia Tertiary Care Teaching Institute of India for the duration of 1 year. All eligible patients were allocated in two groups as GROUP B and GROUP R. GROUP B: 10 mL of 0.5% bupivacaine and 15 I.U. /mL of hyaluronidase. GROUP R: 10 mL of 0.5% ropivacaine and 15 I.U. /mL of hyaluronidase. Patients were assessed for sensory block, eyelid, and ocular movements at an interval of 2 min, and Visual Analog Scale score for pain assessment. Results: Age and gender did not differ significantly between the two study groups, according to the findings. Comparable and similar patient characteristics distinguished the two study groups. (P>0.05). The difference in onset of eyelid motor blockade between the two groups was not statistically significant. The difference in the onset of motor blockade [ocular movement] between the two groups was not statistically significant (P>0.05). (P>0.05) Analgesia duration differed significantly between the two groups in a statistical sense. Ropivacaine exhibits a significantly prolonged duration of analgesic effect than bupivacaine (P≤0.05). Conclusion: Peribulbar block utilizing 0.5% ropivacaine is a more favorable and secure option for a local anesthetic that effectively extends postoperative pain alleviation, in comparison to the use of 0.5% bupivacaine.
Protein Stability in Pasteurized Cow and Goat Milk using Protein Gel Electrophoresis

Milk is a nutritious beverage that contains whey, casein, and milk fat globule membrane (MFGM) proteins. Pasteurization kills pathogenic microorganisms in milk, making it safe to drink. A high heat load during processing can affect the protein quality of milk. In this study, protein gel electrophoresis (Native and SDS-PAGE) was used to view the protein profiles of retail cow and goat milk samples pasteurized at different temperatures (145, 165, or 280 °F) compared to commercially spray dried milk (356–482 °F). SDS-PAGE provided better resolution of the milk proteins compared to Native-PAGE. There were clear species differences in the MFGM proteins. This could be used to spot adulteration of goat milk with cow milk, however none of the samples showed signs of adulteration. There were no overt patterns of protein degradation with increasing pasteurization temperature. However drying reduced band intensity, especially MFGM and whey proteins in the goat milk sample. Whereas most samples came from different herds where genetics and environmental conditions varied, two of the goat milk samples were from the same herd, one fresh and one spray dried. It was evident from these two samples that spray drying can alter proteins in goat milk. Even so, if fresh milk is unavailable or unaffordable, dry milk remains a valuable protein source.
ADVANCEMENTS IN ANTENNA ARRAY DESIGN FOR 5G COMMUNICATION NETWORKS: A COMPREHENSIVE REVIEW

This research paper presents a comprehensive review of recent advancements in antenna array design, specifically tailored for 5G communication networks. The evolution of 5G technology demands novel antenna solutions to meet the increasing demand for higher data rates, lower latency, and improved spectral efficiency. The paper explores various antenna array architectures, including phased arrays, MIMO systems, and beamforming techniques, highlighting their respective advantages and challenges. Furthermore, the study discusses the integration of advanced materials and technologies in antenna design to enhance performance parameters. Key considerations such as size, power consumption, and cost-effectiveness are also addressed. The presented insights contribute to the ongoing efforts to optimize antenna arrays for the next generation of communication networks.
Modification of 4-(4-chlorothiophen-2-yl)thiazol-2-amine derivatives for the treatment of analgesia and inflammation: synthesis and in vitro, in vivo, and in silico studies

Inflammation is a protective response to a variety of infectious agents. To develop a new anti-inflammatory drug, we explored a pharmacologically important thiazole scaffold in this study. In a multi-step synthetic approach, we synthesized seven new thiazole derivatives (5a–5g). Initially, we examined the in vitro anti-inflammatory potentials of our compounds using COX-1, COX-2, and 5-LOX enzyme assays. After in vitro confirmation, the potential compounds were subjected to in vivo analgesic and anti-inflammatory studies. The hot plate method was used for analgesia, and carrageenan-induced inflammation was also assayed. Overall, all our compounds proved to be potent inhibitors of COX-2 compared to celecoxib (IC50 0.05 μM), exhibiting IC50 values in the range of 0.76–9.01 μM . Compounds 5b, 5d, and 5e were dominant and selective COX-2 inhibitors with the lowest IC50 values and selectivity index (SI) values of 42, 112, and 124, respectively. Similarly, in the COX-1 assay, our compounds were relatively less potent but still encouraging. Standard aspirin exhibited an IC50 value of 15.32 μM. In the 5-LOX results, once again, compounds 5d and 5e were dominant with IC50 values of 23.08 and 38.46 μM, respectively. Standard zileuton exhibited an IC50 value of 11.00 μM. Based on the COX/LOX and SI potencies, the compounds 5d and 5e were subjected to in vivo analgesic and anti-inflammatory studies. Compounds 5d and 5e at concentrations of 5, 10, and 20 mg/kg body weight were significant in animal models. Furthermore, we explored the potential role of compounds 5d and 5e in various phlogistic agents. Similarly, both compounds 5d and 5e were also significantly potent in the anti-nociceptive assay. The molecular docking interactions of these two compounds with the target proteins of COX and LOX further strengthened their potential for use in COX/LOX pathway inhibitions.
Microbial Response to Varying Concentrations of Crude Oil Pollution of Agricultural Soils in Ondo State, Nigeria

This research investigated the effects of varying concentrations of crude oil on the population of crude oil degrading microorganisms in crude oil polluted agricultural soils from IgodanLisa, ObaIle and Ido-Ani areas of Ondo State, Nigeria. The soil samples were exposed to 14% (w/w) crude oil and analyzed monthly for six periods using standard microbiological techniques for the cultivation and enumeration of crude oil degrading bacteria and fungi. Results indicated that the crude oil degrading microbial populations were significantly altered. The population of crude oil degrading microbes were higher (1.03 x 10 1.10 x 10 cfu/g for bacteria and 1.07 x 10 – 8.67 x 10 sfu/g for fungi) in polluted than unpolluted (1.53 x 10 – 9.40 x 10 cfu/g for bacteria and 1.17 x 10 – 5.17 x 10 sfu/g for fungi) soils and also varied with increase in the amount of crude oil spilled and time. The mean count indicated that the microbiological status of the soil samples were not negatively impacted at 1-4% crude oil contamination and the effect on soil micro flora is a function of both concentration and contact time.