Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of anti-rheumatic drugs during pregnancy

Publisher Summary This chapter discusses that rheumatic diseases management in women of childbearing years involves counseling about contraception and pregnancy. Judicious decisions have to be made according to each case, and issues related to a pregnancy are of particular concern because of the fetus. Some drugs classified as being of higher risk based on animal studies, are used during pregnancy to control maternal disease activity. The common advice to women with autoimmune rheumatic diseases, especially systemic lupus erythematosus (SLE), systemic sclerosis and vasculitic syndromes, has avoided pregnancy because of the perception that maternal or fetal risks were of an unacceptable magnitude. The chapter discusses that there is an agreement that pregnancy should be postponed until major disease activity is treated and certain appropriate medications should be continued to reduce the chances of disease flare during pregnancy. Most of the data on pregnancy and autoimmune rheumatic conditions derive from retrospective analyses, but some prospective studies involve the use of anti-rheumatic drugs that have been performed in the past two decades. During pregnancy, nonsteroidal anti-inflammatory drug (NSAID) is used until the last 6 weeks; low to moderate doses of corticosteroids are relatively safe throughout pregnancy. Women using heparin for treatment of anti-phospholipid antibody syndrome like those taking corticosteroids should take measures to prevent bone loss. Corticosteroids are frequently necessary to control rheumatic disease flares and for prevention of serious organic damage. Among disease-modifying drugs, sulfasalazine, and anti-malarials have the safest record.
Lupus and Serologic Autoimmunity in a IFN-Is Associated with Increased Sensitivity to Autoimmune Disease Risk Variant of IFIH1

Increased IFN- a signaling is a heritable risk factor for systemic lupus erythematosus (SLE). IFN induced with helicase C domain 1 (IFIH1) is a cytoplasmic dsRNA sensor that activates IFN- a pathway signaling. We studied the impact of the autoimmune-disease–associated IFIH1 rs1990760 (A946T) single nucleotide polymorphism upon IFN- a signaling in SLE patients in vivo. We studied 563 SLE patients (278 African-American, 179 European-American, and 106 Hispanic-American). Logistic regression models were used to detect genetic associations with autoantibody traits, and multiple linear regression was used to analyze IFN- a –induced gene expression in PBMCs in the context of serum IFN- a in the same blood sample. We found that the rs1990760 T allele was associated with anti-dsDNA Abs across all of the studied ancestral backgrounds (meta-analysis odds ratio = 1.34, p = 0.026). This allele also was associated with lower serum IFN- a levels in subjects who had anti-dsDNA Abs ( p = 0.0026). When we studied simultaneous serum and PBMC samples from SLE patients, we found that the IFIH1 rs1990760 T allele was associated with increased IFN-induced gene expression in PBMCs in response to a given amount of serum IFN- a in anti-dsDNA–positive This effect was independent of the STAT4 genotype, which modulates sensitivity to IFN- a in a similar way. Thus, the IFIH1 rs1990760 Tallele was associated with dsDNA Abs, and in patients with anti-dsDNA Abs this risk allele increased sensitivity to IFN- a signaling. These studies suggest a role for the IFIH1 risk allele in SLE in vivo. The Journal of Immunology , 2011, 187: 000–000.
POST-TRANSCRIPTIONAL REGULATION OF ALPHA-SYNUCLEIN EXPRESSION BY MIR-7 AND MIR-153

From Basic Neurosciences Division, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens 11527, Greece Running head: Post-transcriptional regulation of SNCA Address correspondence to: Epaminondas Doxakis, Basic Neurosciences Division, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens 11527, Greece. Fax: 30-210-659545; Email: edoxakis@bioacademy.gr
Chordoid Meningioma: A Short Series of Five Cases at a Single Institution and Literature Review

Introduction: The purpose of this study was to report a series of five cases of chordoid meningioma to describe the clinical, pathological, and immunohistochemical features associated with each case and perform a literature review. Methods: A retrospective chart review was performed on five patients diagnosed with chordoid meningioma and treated at the University of Toledo Medical Center between January 2007 and January 2015. Clinical data obtained includes age, sex, presenting clinical symptoms, duration of symptoms, tumor size, tumor location, treatment, extent of resection, follow-up time, adjuvant therapy, recurrence, and permanent deficits at last follow-up. All cases were diagnosed microscopically by a neuropathologist and immunohistochemistry was performed on two cases. Results: All patients were female, average age was 55.6 years (range 43- 73), and the most common symptom experienced was headache (n=5). No patients experienced any systemic manifestations of Castleman syndrome. Tumor locations were temporal lobe (n=3), cervical spine (n=1), and frontal lobe (n=1). Average time for follow-up was 38.8 months. Simpson grade I and IV resections were performed in three and two patients, respectively. Recurrence was seen in one patient who underwent grade I resection, and progression was seen in one patient who underwent grade IV resection. No patients underwent adjuvant therapy. Mild deltoid weakness and blurry vision in two patients were the only two deficits noted post resection. Both tumors that had immunohistochemistry performed were positive for progesterone receptor. Conclusion: Clinical, pathological, and immunohistochemical features of chordoid meningiomas were analyzed and compared with current literature. to highlight and differences in
Inhibition of GLUT4 Translocation by Tbc1d1, a Rab GTPase Activating Protein Abundant in Skeletal Muscle, is Partially Relieved by AMPK Activation*

Tbc1d1 knockdown on cell surface GLUT4. Part A. The relative amount of HA-GLUT4-GFP at the cell surface in basal and insulin-stimulated adipocytes at day 5 of differentiation expressing control shRNA or Tbc1d1 shRNA (KD) was measured as described in the Experimental Procedures. The results are the averages +/- SEM from three measurements. Part B. Tbc1d1 was immunoprecipitated from an SDS/C12E9 lysates of day 5 adipocytes expressing control shRNA or Tbc1d1 shRNA, and equal portions of the immunoprecipitates were immunoblotted for Tbc1d1. A repetition of the experiments in parts A and B starting with the generation of the cells expressing shRNAs gave similar results.
Examples on Oral Communication Analysis Using Nonlinear Techniques.

: This paper analyzes the time series obtained from the digitalization of the oral reading of a text. A control model based on the RS-232 standard is used to extract synthetic time series and to compare their different behavior. Nonlinear techniques are used in order to recognize rules and experimental behavior models. These techniques help us to understand the physical structure of communication and allow us to recognize the existence of internal rules associated with the content of the communication. The proofs made shows similarities between human voice and the binary model based on RS-232.
EAP-Kerberos: Leveraging the Kerberos Credential Caching Mechanism for Faster Re-authentications in Wireless Access Networks

—Although the wireless technology nowadays provides satisfying bandwidth and higher speeds, it still lacks improvements with regard to handoff performance. Existing solutions for reducing handoff delays are speciﬁc to a particular network technology or require expensive upgrades of the whole infrastructure. In this paper, we investigate performance beneﬁts of leveraging the Kerberos ticket cashing mechanism for achieving faster re-authentications in IEEE 802.11 wireless access networks. For this purpose, we designed a new EAP authentication method, EAP-Kerberos, and evaluated re-authentication performance in different scenarios.
OBSESSIVE COMPULSIVE SYMPTOMS IN MIGRAINE WITH AURA AND WITHOUT AURA - A COMPARATIVE STUDY

Psychiatric symptoms, such as anxiety, depression and obsessive compulsive symptoms are seen more in migraine patients than general population with some research suggesting higher comorbidity in migraine with aura than migraine without aura. Establishing of these symptoms is important in terms of successful management. The aim of the study was to compare the levels of obsessive-compulsive symptoms between migraine with aura and migraine without aura and to detect the relationship of the levels of these disorders with duration of disease and frequency of the attacks. The sample of 30 migraine patients was included in the study out of whom 19 patients were of migraine without aura and 11 were migraine with aura. Migraine diagnosis was made by psychiatrist trained in treating headaches and OC symptoms were evaluated by means of the Yale-Brown Obsessive Compulsive Screening Scale. All 30 patients were diagnosed as per new international classiﬁcation of headache disorders (ICHD-III) criteria and were selected as per inclusion and exclusion criteria and after well informed written consent. It was found that among the patients of migraine with aura, most of them had sensory type of aura. Most of the patients out of the total sample were also found to contain obsessive and compulsive symptoms out of which contamination obsession and cleaning compulsion were most common.
Antioxidant Activity and Total Polyphenol Content of Medicinal Herbs with Adaptogenic Effect to Human Body

Nowadays, medicinal herbs with an adaptogenic effect to human body start be very popular not only in medicine but also in food industry due to the high amount of bioactive compounds. The aim of this study was to determine antioxidant activity, total polyphenol, flavonoid and phenolic acid content of five plants with adaptogenic affect to human body: Eurycoma longifolia Jack. , Lepidium meyenii Walp. , Turnera diffusa Wild. , Tribulus terrestris L. and Rhodiola rosea L. The antioxidant activity was detected by DPPH and phosphomolybdenum method, total polyphenol content with Folin – Ciocalteu reagent, flavonoids content by aluminium chloride method and total phenolic acid content by Arnova reagent. The highest antioxidant activity by DPPH and phosphomolybdenum method was determined in the sample of Rhodiola rosea L. (6.82 mg TEAC – Trolox equivalent antioxidant capacity per g of sample and 315.37 mg TEAC per g). In this sample was also measured the highest content of total polyphenols (76.64 mg GAE – gallic acid equivalent per g of sample) and phenolic acid (25.10 mg CAE – caffeic acid equivalent per g of sample). Total flavonoid content (20.80 mg QE – quercetin equivalent per g of sample) was the highest in sample of Tribulus terrestris L. Results showed that medicinal herbs with adaptogenic effect are rich for polyphenol compounds with antioxidant activity and can be use more in food industry as functional food additives.
Linewidth enhancement factor in a microcavity Brillouin laser: supplement

This document provides supplementary information to “ L inewidth enhancement factor in a microcavity Brillouin laser . ” In section 1, we discuss the equivalence of the α factor and the normalized detuning of the Brillouin laser, as well as its connections to the α factor commonly used in semiconductor lasers. In section 2, we review the frequency discriminator measurements used in the main text to determine laser frequency noise. In section 3, we present a full analysis of the Brillouin laser noise, including the effects of pump phase noise. In section 4, a measurement of the α factor enhanced noise measured on a second device is presented. In section 5 measurement of the relative intensity noise of the Brillouin laser is presented. In section 6, we study the effect of the anti-Stokes process on the α -factor linewidth enhancement in a cascaded Brillouin laser system.
A novel deep penetrating eddy current probe based on phase shifted fields and its application to inspection of defects

Due to the skin eﬀect of eddy currents, the depth of cracks which can be detected by the traditional eddy current probe is very limited. In order to improve the ability of eddy current probes to inspect deep cracks in metal thick-walled structures, a new eddy current probe using an excitation system with phase shifted ﬁelds was proposed. Its feasibility for detecting deep cracks was veriﬁed by simulation and experiments. The results showed that the penetration depth of eddy currents in austenitic stainless steel is eﬀectively enhanced by using the new probe.
Impact of Vocational Training on Employment and Earnings of Federally Administered Tribal Area’s Youth in Pakistan

: Federally Admininstered Tribal Areas Development Authority (FATA-DA) imparted vocational training to more than fifty two thousands individual in seventy different potential technologies/trades. This study was conducted with the aim to evaluate the socio-economic impact of those training in FATA. Survey was initiated in the year 2018 and primary data was collected from 400 respondents selected through a disproportionate stratified random sampling procedure. Both descriptive statistics and regression analysis were undertaken for the analysis of data. The findings revealed that FATA-DA training has made a substantial contribution to young people's socioeconomic development. After completing FATA-DA training, youth employment increased by 1.94 times and monthly earnings by 1.63 times. It was also shown that the respondents' age had a substantial positive link with their employment and wages. According to the study, respondents who had some work experience prior to Institute Based Training (IBT) were able to get jobs faster and earn more money than those who did not. The study also identified certain programme quality shortcomings, such as a lack of effective career counselling for trainees, a lack of proper linkage of IBT with the relevant sector, a lack of post-training financial support, and a lack of internship opportunities. This study was the first-ever evaluation study of the vocational training program of FATA-DA. The study suggests that policymakers should concentrate on the quality parameters of any vocational training programme during implementation in order to achieve the best possible results.
Phishing Awareness and Susceptibility of System Users

The significant rise in the occurrences of phishing events or attacks is very disturbance from the society view point as it extends varied sects of people each year. With an enormous amount of money lost to online crimes, security on the web becomes increasingly important. Security experts need to understand the ways by which individual’s interaction with phishing attacks and their way of behavior. There is a need for a deeper understanding of people Attitude, Intentions, Behavior, in order to protect them from falling into the clutches of the cybercriminals. This research work has attempted in order to understand potential risks of information security posed by computer system users as they are the weakest link in the information security range of defense. The study examines the awareness of users to decrease the risk of e-mail phishing by studying the awareness of phishing among Computer System users.
Typical Shape Differences in the Subtalar Joint Bones Between Subjects with Chronic Ankle Instability and Controls

: Bone shapes, particularly those defining the subtalar joint (STJ), have not received much attention yet as a risk factor for developing chronic ankle instability (CAI) after sustaining a lateral ankle sprain (LAS). This study aimed to compare three ‐ dimensional (3D) shape variations in the STJ bones within individuals with CAI and healthy controls. 3D statistical shape models (SSMs) of the STJ bones were built to describe the bone shape variations observed within a population consisting of 26 individuals with unilateral CAI and 26 healthy controls. Using the SSMs and analysis of covariance test, age ‐ and gender ‐ adjusted shape variations in the bones were compared within individuals with CAI and healthy controls. The mean age of the CAI patients (14 males and 12 females) and healthy controls (12 males and 14 females) was 29 (standard deviation [SD]=11) and 36 years (SD=11), respectively. Tali and calcanei did not significantly vary between ipsilateral CAI and their contralateral ankle. Two shape modes, one for the talus ( p =0.015, variations in the curvature of the talar lateral process and the inclination angle of the talar neck relative to the body) and one for the calcaneus ( p =0.003, variations in the medial and lateral tuberosities, and the contour of the anterior articular surface), described significant shape differences between the CAI patients and healthy controls. The CAI patients generally had flatter talar joint surfaces and a flattened calcaneal ground ‐ contact surface. These findings suggest that specific bone shapes may increase the risk of developing CAI after sustaining a LAS. © 2019 The Authors. Journal of Orthopaedic Research ® published by Wiley Periodicals, Inc. on behalf of Orthopaedic Research Society. J Orthop Res 37:1892 – 1902, 2019 age and gender, an analysis of covariance (ANCOVA) test was performed considering the age and gender as covariate factors. To assess whether the shape parameters (i.e., b values) across all tali and calcanei for each mode of shape variation conform to a normal distribution, a Kolmogorov – Smirnoff test was applied prior to our statistical analyses. All statistical analyses were carried out using SPSS (version 22; Chicago, IL).
BELIEFS AND KNOWLEDGE ABOUT CANCER AMONG EDUCATED SAUDI WOMEN IN RIYADH CITY

could be an obstacle of early diagnosis. Also low level of knowledge about oral cancer was found among young adults in Jazan region. [15] A study conducted in Riyadh area aimed to assess the awareness of cancer among hospital attendants. The findings of that study revealed a low awareness of the ABSTRACT Introduction: Negative cultural beliefs as well as financial barriers could reduce early detection and affect provision of optimal care for cancer patients. Even with sufficient resources provided for a prevention program, inability to identify those internal obstacles could decrease the program impact. The main aim of this study was to determine the knowledge and misconceptions about cancer among Saudi educated women . Methods: This is a cross sectional study carried out in the form of a survey using convenient sample of 155 educated Saudi female. The study participants were interviewed personally in major commercial centres in Riyadh city. A written consent was obtained before data collection and the response rate was very high in this study, since the data collected by trained data collectors using personal interview method. The data were entered and cleaned, then analysed using SPSS software version 20. Results: About 32% of study participants think they have adequate information about cancer. While the majority believes, cancer is a common disease in Saudi Arabia. Around 60% think that all the people who have cancer almost die. Only 17% believe traditional methods such as herbs, spell, or oriental medicine could treat cancer. Around 37% think that cancer is a God punishment, and 25% think that evil eye and envy is a cause of cancer. Conclusion: this study found younger, more educated women, women with positive familial history of cancer, or women obtained information from scientific sources have significantly higher level of knowledge of cancer and less false beliefs and misconceptions.
The TraT protein of Folac-- unlike TraT of F or R 6-5 not restore outer membrane integrity in the SSA class of permeability mutants of Salmonel la typhimurium-- does

The TraT proteins produced by F or related plasmid R6-5 restore the normal permeability bartier function of outer membrane of antibiotic-supersensitive SS-A mutants of Salmonella typhimurium. Despite of extensive homology between TraT proteins of F and Folac the protein of Folac, synthesized under repressed or derepressed conditions from traT introduced on different plasmids, did not complement the SS-A phenotype.
STRENGTHENING ECOLOGY OF CITIZENSHIP AS A SUSTAINABLE DEVELOPMENT

This article discusses the reality of the current destruction of nature caused by various aspects of human action. The virtue of civic virtue in the environmental field is getting lower and the decline of morals is characterized by the widespread destruction of nature through various actions, the indiscriminate disposal of garbage and industrial waste, the decline in the quality of fresh air and clear water. This is a condition that reinforces the attention of all parties will be important and urgent efforts to strengthen conservation awareness and maintain the balance of the environment so that the balance can still be maintained and maintained. This condition certainly requires an alternative step solution that includes all components of society, especially in the school as the basis of citizenship education. One of the efforts to maintain and maintain and preserve the balance is the role of Citizenship Education (Civics), especially Citizenship Education is treated as an ecological education that is practically starting from school to be applied in the home environment as a practice of habituation of environmental care for virtue internalization and compassion to the wider environment (community). This argument when viewed from the point of Citizenship Education is the main estuary of Civic learning ie civic virtue.
Integrating strategic human capital and strategic human resource management

Human capital is an important construct in a variety of fields spanning from micro scholarship in psychology to macro scholarship in economics. Within the various disciplinary perspectives, research focuses on slightly different aspects and levels of human capital within organizations, which may give opportunities for integration. The current paper aims to increase knowledge about human capital within organizations by integrating two streams of research which focus directly on human capital, but have approached human capital in different ways: strategic human capital (SHC), and strategic HRM. We describe both SHC and strategic HRM research streams and propose areas of integration, and directions for future research on human capital in organizations.
The Merging and Integration of Two General Aviation Companies: A Case Study in Effective Leadership

The purpose of this study is to identify the optimal leadership skills and qualities necessary for the effective merger and integration of two general aviation companies, the Cessna Aircraft Company and Beechcraft Corporation. The purposive sample used in this study is comprised of leadership interviews identified as having significant industry knowledge and internal information on the initiative. This research study is significant in that it provides relevant insights regarding the importance and effectiveness of desired leadership skills throughout a successful merger and integration process. Companies will continue to merge and integrate, including aviation companies, for variety of reasons including: growth stimulation, diversification of business interests, elimination of compe-tition, pricing power related to supply chains, or tax benefits. As evident in this research study, there are determining factors regarding leadership that effect a successful merger and integration.