Miracle-dz/UniFAR-FTUs huggingface dataset:
Intrinsic structural instabilities of domain walls driven by gradient coupling: Meandering antiferrodistortive-ferroelectric domain walls inBiFeO3

Using Landau-Ginzburg-Devonshire approach, we predict the intrinsic instability of the ferroelectric-ferroelastic domain walls in the multiferroic BiFeO3 emerging from the interplay between the gradient terms of the antiferrodistortive and ferroelectric order parameters at the walls. These instabilities are the interface analogue of the structural instabilities in the vicinity of phase coexistence in the bulk; and so they do not steam from incomplete polarization screening in thin films or its spatial confinement, electrostrictive or flexoelectric coupling. The effect of BiFeO3 material parameters on the 71 degree, 109 degree, and 180 degree walls is explored, and it is shown that the meandering instability appears at 109 degree, and 180 degree walls for small gradient energies, and the walls become straight and broaden for higher gradients. In contrast to the 180 degree and 109 degree domain walls, uncharged 71 degree walls are always straight, and their width increases with increasing the tilt gradient coefficient. The wall instability and associated intrinsic meandering provide a new insight into the behavior of morphotropic and relaxor materials, wall pinning, and mechanisms of interactions between order parameter fields and local microstructure.
Can anisotropy in the galaxy distribution tell the bias?

We use information entropy to analyze the anisotropy in the mock galaxy catalogues from dark matter distribution and simulated biased galaxy distributions from $\Lambda$CDM N-body simulation. We show that one can recover the linear bias parameter of the simulated galaxy distributions by comparing the radial, polar and azimuthal anisotropies in the simulated galaxy distributions with that from the dark matter distribution. This method for determination of the linear bias requires only $O(N)$ operations as compared to $O(N^{2})$ or at least $O(N \log N)$ operations required for the methods based on the two-point correlation function and the power spectrum. We apply this method to determine the linear bias parameter for the galaxies in the 2MASS Redshift Survey (2MRS) and find that the 2MRS galaxies in the $K_{s}$ band have a linear bias of $\sim 1.3$.
Genetic Engineering of Talaromyces marneffei to Enhance Siderophore Production and Preliminary Testing for Medical Application Potential

Siderophores are compounds with low molecular weight with a high affinity and specificity for ferric iron, which is produced by bacteria and fungi. Fungal siderophores have been characterized and their feasibility for clinical applications has been investigated. Fungi may be limited in slow growth and low siderophore production; however, they have advantages of high diversity and affinity. Hence, the purpose of this study was to generate a genetically modified strain in Talaromyces marneffei that enhanced siderophore production and to identify the characteristics of siderophore to guide its medical application. SreA is a transcription factor that negatively controls iron acquisition mechanisms. Therefore, we deleted the sreA gene to enhance the siderophore production and found that the null mutant of sreA (ΔsreA) produced a high amount of extracellular siderophores. The produced siderophore was characterized using HPLC-MS, HPLC-DAD, FTIR, and 1H- and 13C-NMR techniques and identified as a coprogen B. The compound showed a powerful iron-binding activity and could reduce labile iron pool levels in iron-loaded hepatocellular carcinoma (Huh7) cells. In addition, the coprogen B showed no toxicity to the Huh7 cells, demonstrating its potential to serve as an ideal iron chelator. Moreover, it inhibits the growth of Candida albicans and Escherichia coli in a dose-dependent manner. Thus, we have generated the siderophore-enhancing strain of T. marneffei, and the coprogen B isolated from this strain could be useful in the development of a new iron-chelating agent or other medical applications.
A case report of vitiligo following toripalimab therapy for a patient with metastatic melanoma

Dear Editor, The present report relates to a 65-year-old man who underwent extensive resection of skin cancer on his right face in March 2021. Pathological examination of a preoperative biopsy collected from the patient showed that he suffered from malignant melanoma (the pathological findings of malignant melanoma are shown in Figure S1 and Figure S2). The neck computer tomography (CT) was applied 1 week after the tumorectomy, the metastatic lymphomas were found in the right submandibular region and bilateral submandibular region, and no specific anti-tumor treatment was applied. In May 2021, the patient underwent a PET-CT examination, which revealed multiple metastatic lymph nodes in the Ia, Ib, and III areas of the right neck. The patient was treated with recombinant human interferon α-2b (rhIFN-α-2b) as the first-line regimen from May 10, 2021. One month later, on June 06, 2021, magnetic resonance imaging (MRI) was applied, and new lymph node metastases were developed in the submental area,
Absorption systems at z∼ 2 as a probe of the circumgalactic medium: a probabilistic approach

We characterize the properties of the intergalactic medium (IGM) around a sample of galaxies extracted from state-of-the-art hydrodynamical simulations of structure formation in a cosmological volume of 25 Mpc comoving at $z\sim 2$. The simulations are based on two different subresolution schemes for star formation and supernova feedback: the MUlti-Phase Particle Integrator (MUPPI) scheme and the Effective Model. We develop a quantitative and probabilistic analysis based on the apparent optical depth method of the properties of the absorbers as a function of impact parameter from their nearby galaxies: in such a way we probe different environments from circumgalactic medium to low-density filaments. Absorbers' properties are then compared with a spectroscopic observational data set obtained from high-resolution quasar spectra. Our main focus is on the N$_{\rm{ CIV}}$-N$_{\rm { HI}}$ relation around simulated galaxies: the results obtained with MUPPI and the Effective model are remarkably similar, with small differences only confined to regions at impact parameters $b = [1-3] \times r_{\rm {vir}}$. Using $\mbox{C IV}$ as a tracer of the metallicity, we obtain evidence that the observed metal absorption systems have the highest probability to be confined in a region of 150-400 kpc around galaxies. Near-filament environments have instead metallicities too low to be probed by present-day telescopes, but could be probed by future spectroscopical studies. Finally we compute $\mbox{C IV}$ covering fractions which are in agreement with observational data.
News from the isolated ellipticals NGC 5812, NGC 7507, and NGC 7796

Abstract We report on ongoing photometric and spectroscopic work on a sample of isolated elliptical galaxies. We investigate their globular cluster systems, and use the kinematics of globular clusters and the integrated galaxy light to constrain their dark halos, which are not found in the cases of NGC 5812 and NGC 7507.
Synaptic Remodeling of the Auditory Cortex Following Bilateral Blindness: Evidence of Cross-modal Plasticity

We aimed to evaluate structural dynamic changes of neurons in the auditory cortex after visual deprivation. We longitudinally tracked dendritic spines for 3 weeks after visual deprivation in vivo using a two-photon microscope. GFP-labeled dendritic spines in the auditory cortex were serially followed after bilateral enucleation. The turnover rate, density, and size of the spines in the dendrites were evaluated 1, 2, and 3 weeks after visual deprivation. The turnover rate of the dendritic spines in the auditory cortex increased at 1 week (20.1±7.3%) after bilateral enucleation compared to baseline (12.5±7.9%); the increase persisted for up to 3 weeks (20.9±11.0%). The spine loss rate was slightly higher than the spine gain rate. The average spine density (number of spines per 1 μm of dendrite) was significantly lower at 2 weeks (2W; 0.22±0.06 1/μm) and 3 W (0.22±0.08 1/μm) post-nucleation compared to baseline (0.026±0.09 1/μm). We evaluated the change of synaptic strength in the stable spines at each time point. The normalized spine size in the auditory cortex was significantly increased after bilateral blindness at 1 W postoperatively (1.36±0.92), 2 W postoperatively (1.40±1.18), and 3 W postoperatively (1.36±0.88) compared to baseline. Sensory deprivation resulted in remodeling of the neural circuitry in the spared cortex, via cross-modal plasticity in the direction of partial breakdown of synapses, and enhanced strength of the remaining synapses.
The direct drivers of recent global anthropogenic biodiversity loss

Effective policies to halt biodiversity loss require knowing which anthropogenic drivers are the most important direct causes. Whereas previous knowledge has been limited in scope and rigor, here we statistically synthesize empirical comparisons of recent driver impacts found through a wide-ranging review. We show that land/sea use change has been the dominant direct driver of recent biodiversity loss worldwide. Direct exploitation of natural resources ranks second and pollution third; climate change and invasive alien species have been significantly less important than the top two drivers. The oceans, where direct exploitation and climate change dominate, have a different driver hierarchy from land and fresh water. It also varies among types of biodiversity indicators. For example, climate change is a more important driver of community composition change than of changes in species populations. Stopping global biodiversity loss requires policies and actions to tackle all the major drivers and their interactions, not some of them in isolation.
The study of multi-frequency scattering of 10 radio pulsars

We present the results of the multi-frequency scatter time measurements for ten radio pulsars that were relatively less studied in this regard. The observations were performed using the Giant Meterwave Radio Telescope at the observing frequencies of 150, 235, 325, 610 and 1060~MHz. The data we collected, in conjunction with the results from other frequencies published earlier, allowed us to estimate the scatter time frequency scaling indices for eight of these sources. For PSR J1852$-$0635 it occurred that its profile undergoes a strong evolution with frequency, which makes the scatter time measurements difficult to perform, and for PSR J1835$-$1020 we were able to obtain reliable pulse broadening estimates at only two frequencies. We used the eight frequency scaling indices to estimate both: the electron density fluctuation strengths along the respective lines-of-sight, and the standardized amount of scattering at the frequency of 1 GHz. Combining the new data with the results published earlier by Lewandowski et al., we revisited the scaling index versus the dispersion measure (DM) relation, and similarly to some of the earlier studies we show that the average value of the scaling index deviates from the theoretical predictions for large DM pulsars, however it reaches the magnitude claimed by L\"ohmer et al. only for pulsars with very large DMs ($>$650 pc cm$^{-3}$). We also investigated the dependence of the scattering strength indicators on the pulsar distance, DM, and the position of the source in the Milky Way Galaxy.
Change Toward Healthier Lifestyles Is Associated With Better Health-Related Quality of Life in Long-Term Colorectal Cancer Survivors.

BACKGROUND Little is known about how changes in a constellation of lifestyle factors affect health-related quality of life (HRQoL) in colorectal cancer (CRC) survivors. Our study aimed to investigate the association between changes in healthy lifestyle and HRQoL over time in survivors of stage I-IV CRC. METHODS We included 2,283 long-term (≥5 years postdiagnosis) survivors. A healthy lifestyle score (HLS) comprising smoking, alcohol consumption, diet, physical activity, and body fatness was derived at diagnosis and 5-year follow-up (5YFU) and categorized as low, moderate, or high. We assessed HRQoL with the EORTC Quality of Life Questionnaire-Core 30 at 5YFU and 10-year follow-up. We used multivariable linear regression and linear mixed models to explore associations between changes in HLS and HRQoL over follow-up. RESULTS A low baseline HLS was associated with poorer functioning and global health/QoL and a higher symptom burden at 5YFU compared with a high baseline HLS. An improved HLS from baseline to 5YFU was associated with better functioning, higher global health/QoL, and fewer symptoms at 5YFU than a maintained-high HLS. In longitudinal analyses, improved HLS was associated with better functioning at follow-up. Survivors with a maintained-high or an improved HLS reported generally less fatigue, pain, and dyspnea at follow-ups compared with survivors with a maintained-low or decreased HLS. CONCLUSIONS Change toward a healthier lifestyle since diagnosis was associated with better HRQoL in long-term CRC survivors. Our results support the importance of maintaining and/or promoting a healthier lifestyle among CRC survivors postdiagnosis.
SWIFT-BAT HARD X-RAY SKY MONITORING UNVEILS THE ORBITAL PERIOD OF THE HMXB IGR J18219−1347

IGR J18219−1347 is a hard X-ray source discovered by INTEGRAL in 2010. We have analyzed the X-ray emission of this source exploiting the Burst Alert Telescope (BAT) survey data up to 2012 March and the X-Ray Telescope (XRT) data that include also an observing campaign performed in early 2012. The source is detected at a significance level of ∼13 standard deviations in the 88 month BAT survey data, and shows a strong variability along the survey monitoring, going from high intensity to quiescent states. A timing analysis on the BAT data revealed an intensity modulation with a period of P0 = 72.44 ± 0.3 days. The significance of this modulation is about seven standard deviations in Gaussian statistics. We interpret it as the orbital period of the binary system. The light curve folded at P0 shows a sharp peak covering ∼30% of the period, superimposed to a flat level roughly consistent with zero. In the soft X-rays the source is detected only in 5 out of 12 XRT observations, with the highest recorded count rate corresponding to a phase close to the BAT folded light-curve peak. The long orbital period and the evidence that the source emits only during a small fraction of the orbit suggests that the IGR J18219−1347 binary system hosts a Be star. The broadband XRT+BAT spectrum is well modeled with a flat absorbed power law with a high-energy exponential cutoff at ∼11 keV.
A discussion of Bl conservation on a two dimensional magnetic field plane in watt balances

The watt balance is an experiment being pursued in national metrology institutes for precision determination of the Planck constant h. In watt balances, the 1/r magnetic field, expected to generate a geometrical factor Bl independent to any coil horizontal displacement, can be created by a strict two dimensional, symmetric (horizontal r and vertical z) construction of the magnet system. In this paper, we present an analytical understanding of magnetic field distribution when the r symmetry of the magnet is broken and the establishment of the Bl conservation is shown. By using either Gauss’s law on magnetism with monopoles or conformal transformations, we extend the Bl conservation to arbitrary two dimensional magnetic planes where the vertical magnetic field component equals zero. The generalized Bl conservation allows a relaxed physical alignment criteria for watt balance magnet systems.
Effects of Benzene: Hematological and Hypersensitivity Manifestations in Resident Living in Oil Refinery Areas

Literature is teeming with publications on industrial pollution. Over the decades, the main industrial pollutants and their effects on human health have been widely framed. Among the various compounds involved, benzene plays a leading role in the onset of specific diseases. Two systems are mainly affected by the adverse health effects of benzene exposure, both acute and chronic: the respiratory and hematopoietic systems. The most suitable population targets for a proper damage assessment on these systems are oil refinery workers and residents near refining plants. Our work fits into this area of interest with the aim of reviewing the most relevant cases published in the literature related to the impairment of the aforementioned systems following benzene exposure. We perform an initial debate between the two clinical branches that see a high epidemiological expression in this slice of the population examined: residents near petroleum refinery areas worldwide. In addition, the discussion expands on highlighting the main immunological implications of benzene exposure, finding a common pathophysiological denominator in inflammation, oxidative stress, and DNA damage, thus helping to set the basis for an increasingly detailed characterization aimed at identifying common molecular patterns between the two clinical fields discussed.
BANYAN. VI. DISCOVERY OF A COMPANION AT THE BROWN DWARF/PLANET-MASS LIMIT TO A TUCANA–HOROLOGIUM M DWARF

We report the discovery of a substellar companion to 2MASS J02192210–3925225, a young M6 γ candidate member of the Tucana–Horologium association (30–40 Myr). This L4 γ companion has been discovered with seeing-limited direct imaging observations; at a 4″ separation (160 AU) and a modest contrast ratio, it joins the very short list of young low-mass companions amenable to study without the aid of adaptive optics, enabling its characterization with a much wider suite of instruments than is possible for companions uncovered by high-contrast imaging surveys. With a model-dependent mass of 12–15 M Jup ? > , it straddles the boundary between the planet and brown dwarf mass regimes. We present near-infrared spectroscopy of this companion and compare it to various similar objects uncovered in the last few years. The J0219–3925 system falls in a sparsely populated part of the host mass versus mass ratio diagram for binaries; the dearth of known similar companions may be due to observational biases in previous low-mass companion searches.
Statistical Gravitational Waveform Models: What to Simulate Next?

Models of gravitational waveforms play a critical role in detecting and characterizing the gravitational waves (GWs) from compact binary coalescences. Waveforms from numerical relativity (NR), while highly accurate, are too computationally expensive to produce to be directly used with Bayesian parameter estimation tools like Markov-chain-Monte-Carlo and nested sampling. We propose a Gaussian process regression (GPR) method to generate accurate reduced-order-model waveforms based only on existing accurate (e.g. NR) simulations. Using a training set of simulated waveforms, our GPR approach produces interpolated waveforms along with uncertainties across the parameter space. As a proof of concept, we use a training set of IMRPhenomD waveforms to build a GPR model in the 2-d parameter space of mass ratio $q$ and equal-and-aligned spin $\chi_1=\chi_2$. Using a regular, equally-spaced grid of 120 IMRPhenomD training waveforms in $q\in[1,3]$ and $\chi_1 \in [-0.5,0.5]$, the GPR mean approximates IMRPhenomD in this space to mismatches below $4.3\times 10^{-5}$. Our approach can alternatively use training waveforms directly from numerical relativity. Beyond interpolation of waveforms, we also present a greedy algorithm that utilizes the errors provided by our GPR model to optimize the placement of future simulations. In a fiducial test case we find that using the greedy algorithm to iteratively add simulations achieves GPR errors that are $\sim 1$ order of magnitude lower than the errors from using Latin-hypercube or square training grids.
Hydrosols of Veronica Species—Natural Source of Free Volatile Compounds with Potential Pharmacological Interest

In this study, free volatile compounds (FVCs) were isolated from the water fractions (hydrosols) of 10 Croatian Veronica species obtained by hydrodistillation (HD) and microwave-assisted extraction (MAE). The use of different isolation techniques is important for the analysis of the influence of extraction conditions on the qualitative and quantitative composition of the isolated constituents. The composition of the hydrosols was analyzed using gas chromatography and mass spectrometry. The compounds β-ionone and benzene acetaldehyde were detected in all 10 Veronica hydrosols studied. E-caryophyllene was also identified in all isolates except the MAE isolate of V. arvensis L. Caryophyllene oxide was isolated in all isolates apart from the HD isolate of V. catenata Pennell. (E)-β-Damascenone is significantly present in all isolates except the MAE isolates of V. catanata and V. cymbalaria Bodard. In these two species, α-muurolol was identified in a high percentage. The same basic phytochemical constituents and compounds characteristic of a given Veronica species suggest the importance of further research. Antioxidant activity was tested for all extracts using two methods, ORAC and DPPH. Therefore, it is crucial to identify as many specialized metabolites from Veronica species as possible, especially hydrosols, which are natural products of potential pharmacological interest.
Stochastic and deterministic processes shape bioenergy crop microbiomes along a vertical soil niche

Abstract Sustainable biofuel cropping systems aim to address climate change while meeting energy needs. Understanding how soil and plant‐associated microbes respond to these different cropping systems is key to promoting agriculture sustainability and evaluating changes in ecosystem functions. Here, we leverage a long‐term biofuel cropping system field experiment to dissect soil and root microbiome changes across a soil‐depth gradient in poplar, restored prairie and switchgrass to understand their effects on the microbial communities. High throughput amplicon sequencing of the fungal internal transcribed spacer (ITS) and prokaryotic 16S DNA regions showed a common trend of root and soil microbial community richness decreasing and evenness increasing with depth. Ecological niche (root vs. soil) had the strongest effect on community structure, followed by depth, then crop. Stochastic processes dominated the structuring of fungal communities in deeper soil layers while operational taxonomic units (OTUs) in surface soil layers were more likely to co‐occur and to be enriched by plant hosts. Prokaryotic communities were dispersal limited at deeper depths. Microbial networks showed a higher density, connectedness, average degree and module size in deeper soils. We observed a decrease in fungal‐fungal links and an increase of bacteria–bacteria links with increasing depth in all crops, particularly in the root microbiome.