Miracle-dz/UniFAR-FTUs huggingface dataset:
A Basic Right Denied: The Interplay Between Various Factors Contributing to School Dropouts in Pakistan

Enshrined in different conventions nationally and internationally, education is a fundamental right of every child irrespective of identity and location worldwide. Despite the Universal Declaration of Human Rights (UDHR) 1948 and the United Nations (UN) Convention on the Rights of the Child 1989, education is not accessible and affordable for every child globally due to several entwined factors. Focusing on Pakistan’s Sindh Province, this article identifies the numerous factors that lead to school dropouts and illustrates their interconnectedness. Employing Sen’s Capabilities Approach, we show a relation between freedom and function, whereby a capability can only be a function if there is an opportunity. We conclude and suggest that since the basic right of education is denied in Pakistan owing to sociocultural, economic, and political factors, there is a need to make necessary efforts at the parental as well as national policy level to address it. We also ask for ethnographically rich studies that should comparatively and thoroughly bring this dropout problem to the center stage for generating a comprehensive understanding so that this basic right is given to every child of this country.
Itch Beyond the Skin—Mucosal Itch

Itch is a nociceptive sensation linked with reflexes and cognitive motor actions. We traditionally think of itch as a sensation of the skin related to allergy, an insect sting or interestingly, anxiety and frustration. Less understood and considered are the physiological processes involved in the itching sensation that occurs at mucosal and junctional dermal sites, which is extraordinary as from an evolutionary point of view these sites serve important guardian roles, rich in sensory nerves and inflammatory cells. Despite itch being an ancient reflex and evolutionarily conserved phenomenon, better clinical understanding of the nuances between sites of itch sensation may lead to improved clinical outcomes. This review invites readers to appreciate itch beyond the skin by highlighting several specific itch patterns—nasal, oral, auricular, vulvovaginal, anal, and perineal itch—the pathophysiological mechanisms that underlie them, the clinical patterns these may cause, and some unique treatments.
The Visual Dictionary of Antimicrobial Stewardship, Infection Control, and Institutional Surveillance Data

Objectives Data and data visualization are integral parts of (clinical) decision-making in general and stewardship (antimicrobial stewardship, infection control, and institutional surveillance) in particular. However, systematic research on the use of data visualization in stewardship is lacking. This study aimed at filling this gap by creating a visual dictionary of stewardship through an assessment of data visualization in stewardship research. Methods A random sample of 150 data visualizations from published research articles on stewardship were assessed. The visualization vocabulary (content) and design space (design elements) were combined to create a visual dictionary. Additionally, visualization errors, chart junk, and quality were assessed to identify problems in current visualizations and to provide improvement recommendations. Results Despite a heterogeneous use of data visualization, distinct combinations of graphical elements to reflect stewardship data were identified. In general, bar (n=54; 36.0%) and line charts (n=42; 28.1%) were preferred visualization types. Visualization problems comprised colour scheme mismatches, double y-axis, hidden data points through overlaps, and chart junk. Recommendations were derived that can help to clarify visual communication, improve colour use for grouping/stratifying, improve the display of magnitude, and match visualizations to scientific standards. Conclusions Results of this study can be used to guide data visualization creators in designing visualizations that fit the data and visual habits of the stewardship target audience. Additionally, the results can provide the basis to further expand the visual dictionary of stewardship towards more effective visualizations that improve data insights, knowledge, and clinical decision-making.
Cross-Context Responses to Novelty in Rural and Urban Small Mammals

The Anthropocene is the era of urbanization. The accelerating expansion of cities occurs at the expense of natural reservoirs of biodiversity and presents animals with challenges for which their evolutionary past might not have prepared them. Cognitive and behavioral adjustments to novelty could promote animals’ persistence under these altered conditions. We investigated the structure of, and covariance between, different aspects of responses to novelty in rural and urban small mammals of two non-commensal rodent species. We ran replicated experiments testing responses to three novelty types (object, food, or space) of 47 individual common voles (Microtus arvalis) and 41 individual striped field mice (Apodemus agrarius). We found partial support for the hypothesis that responses to novelty are structured, clustering (i) speed of responses, (ii) intensity of responses, and (iii) responses to food into separate dimensions. Rural and urban small mammals did not differ in most responses to novelty, suggesting that urban habitats do not reduce neophobia in these species. Further studies investigating whether comparable response patters are found throughout different stages of colonization, and along synurbanization processes of different duration, will help illuminate the dynamics of animals’ cognitive adjustments to urban life.
Mineralocorticoid Receptor Antagonists in Diabetic Kidney Disease

Diabetic kidney disease (DKD) is a major cause of end-stage kidney disease (ESKD) worldwide. Mineralocorticoid receptor (MR) plays an important role in the development of DKD. A series of preclinical studies revealed that MR is overactivated under diabetic conditions, resulting in promoting inflammatory and fibrotic process in the kidney. Clinical studies demonstrated the usefulness of MR antagonists (MRAs), such as spironolactone and eplerenone, on DKD. However, concerns regarding their selectivity for MR and hyperkalemia have remained for these steroidal MRAs. Recently, nonsteroidal MRAs, including finerenone, have been developed. These agents are highly selective and have potent anti-inflammatory and anti-fibrotic properties with a low risk of hyperkalemia. We herein review the current knowledge and future perspectives of MRAs in DKD treatment.
Arabidopsis Target of Rapamycin Coordinates With Transcriptional and Epigenetic Machinery to Regulate Thermotolerance

Global warming exhibits profound effects on plant fitness and productivity. To withstand stress, plants sacrifice their growth and activate protective stress responses for ensuring survival. However, the switch between growth and stress is largely elusive. In the past decade, the role of the target of rapamycin (TOR) linking energy and stress signalling is emerging. Here, we have identified an important role of Glucose (Glc)-TOR signalling in plant adaptation to heat stress (HS). Glc via TOR governs the transcriptome reprogramming of a large number of genes involved in heat stress protection. Downstream to Glc-TOR, the E2Fa signalling module regulates the transcription of heat shock factors through direct recruitment of E2Fa onto their promoter regions. Also, Glc epigenetically regulates the transcription of core HS signalling genes in a TOR-dependent manner. TOR acts in concert with p300/CREB HISTONE ACETYLTRANSFERASE1 (HAC1) and dictates the epigenetic landscape of HS loci to regulate thermotolerance. Arabidopsis plants defective in TOR and HAC1 exhibited reduced thermotolerance with a decrease in the expression of core HS signalling genes. Together, our findings reveal a mechanistic framework in which Glc-TOR signalling through different modules integrates stress and energy signalling to regulate thermotolerance.
Treatment Outcome and Risk Factors of Adult Newly Diagnosed Epilepsy: A Prospective Hospital-Based Study in Northeast China

Objective: The study was conducted to summarize the treatment outcomes of newly diagnosed epilepsy (NDE) and analyse the risk factors for refractory epilepsy (RE) in Northeast China. Methods: A total of 466 adult patients with NDE were consecutively enrolled in this programme. Clinical data were collected at baseline and each follow-up. Several scales concerning recognition and mood were also completed at the first visit. Results: Seizure-free status was achieved by 52% (n = 244) of the patients; however, 15% (n = 68) manifested RE. A total of 286 (61%) patients continued with the first ASM as monotherapy, among which 186 (40%) patients became seizure-free. Fifteen (22%) patients with RE became seizure-free following ASM adjustment and 34 patients (14%) had breakthrough seizures after being classified as seizure-free. One patient developed RE after attaining seizure-free status. Breakthrough seizures during the first expected interictal interval [Odds ratio (OR) = 5.81, 95% CI: 2.70–12.50], high seizure frequency at baseline (OR = 1.24, 95% CI: 1.04–1.49), younger age of onset (OR = 1.42, 95% CI: 1.12–1.79), and male sex (OR = 2.64, 95% CI: 1.26–5.53) were risk factors for RE. Significance: Treatment outcomes of the majority of NDE cases are good. New risk factors could help physicians more promptly and accurately identify patients who are likely to develop RE. Seizure-free state is not long enough to commence the withdrawal of ASMs. RE is not permanent and seizure-free may be achieved subsequently by appropriate drug adjustment.
Clinical Trials of the BTK Inhibitors Ibrutinib and Acalabrutinib in Human Diseases Beyond B Cell Malignancies

The BTK inhibitors ibrutinib and acalabrutinib are FDA-approved drugs for the treatment of B cell malignances. Both drugs have demonstrated clinical efficacy and safety profiles superior to chemoimmunotherapy regimens in patients with chronic lymphocytic leukemia. Mounting preclinical and clinical evidence indicates that both ibrutinib and acalabrutinib are versatile and have direct effects on many immune cell subsets as well as other cell types beyond B cells. The versatility and immunomodulatory effects of both drugs have been exploited to expand their therapeutic potential in a wide variety of human diseases. Over 470 clinical trials are currently registered at ClinicalTrials.gov to test the efficacy of ibrutinib or acalabrutinib not only in almost every type of B cell malignancies, but also in hematological malignancies of myeloid cells and T cells, solid tumors, chronic graft versus host disease (cGHVD), autoimmune diseases, allergy and COVID-19 (http:www.clinicaltrials.gov). In this review, we present brief discussions of the clinical trials and relevant key preclinical evidence of ibrutinib and acalabrutinib as monotherapies or as part of combination therapies for the treatment of human diseases beyond B cell malignancies. Adding to the proven efficacy of ibrutinib for cGVHD, preliminary results of clinical trials have shown promising efficacy of ibrutinib or acalabrutinib for certain T cell malignancies, allergies and severe COVID-19. However, both BTK inhibitors have no or limited efficacy for refractory or recurrent solid tumors. These clinical data together with additional pending results from ongoing trials will provide valuable information to guide the design and improvement of future trials, including optimization of combination regimens and dosing sequences as well as better patient stratification and more efficient delivery strategies. Such information will further advance the precise implementation of BTK inhibitors into the clinical toolbox for the treatment of different human diseases.
Basal Ganglia Local Field Potentials as a Potential Biomarker for Sleep Disturbance in Parkinson's Disease

Sleep disturbances, specifically decreases in total sleep time and sleep efficiency as well as increased sleep onset latency and wakefulness after sleep onset, are highly prevalent in patients with Parkinson's disease (PD). Impairment of sleep significantly and adversely impacts several comorbidities in this patient population, including cognition, mood, and quality of life. Sleep disturbances and other non-motor symptoms of PD have come to the fore as the effectiveness of advanced therapies such as deep brain stimulation (DBS) optimally manage the motor symptoms. Although some studies have suggested that DBS provides benefit for sleep disturbances in PD, the mechanisms by which this might occur, as well as the optimal stimulation parameters for treating sleep dysfunction, remain unknown. In patients treated with DBS, electrophysiologic recording from the stimulating electrode, in the form of local field potentials (LFPs), has led to the identification of several findings associated with both motor and non-motor symptoms including sleep. For example, beta frequency (13–30 Hz) oscillations are associated with worsened bradykinesia while awake and decrease during non-rapid eye movement sleep. LFP investigation of sleep has largely focused on the subthalamic nucleus (STN), though corresponding oscillatory activity has been found in the globus pallidus internus (GPi) and thalamus as well. LFPs are increasingly being recognized as a potential biomarker for sleep states in PD, which may allow for closed-loop optimization of DBS parameters to treat sleep disturbances in this population. In this review, we discuss the relationship between LFP oscillations in STN and the sleep architecture of PD patients, current trends in utilizing DBS to treat sleep disturbance, and future directions for research. In particular, we highlight the capability of novel technologies to capture and record LFP data in vivo, while patients continue therapeutic stimulation for motor symptoms. These technological advances may soon allow for real-time adaptive stimulation to treat sleep disturbances.
“ Use of OSINT in a colombian context and sentiment Analysis ”

Open source intelligence (OSINT) is a cyber-intelligence branch used to obtain and analyze information Revista Vínculos http://revistas.udistrital. edu.co/ojs/index.php/vinculos 1. Estudiante Ingeniería de Sistemas. Escuela Colombiana de Ingeniería Julio Garavito. Correo electrónico: ricardo.pinto@mail.escuelaing.edu.co 2. Estudiante Ingeniería de Sistemas. Escuela Colombiana de Ingeniería Julio Garavito. Correo electrónico: martin.hernandez@mail.escuelaing.edu.co 3. Estudiante Ingeniería de Sistemas. Escuela Colombiana de Ingeniería Julio Garavito. Correo electrónico: cristian.pinzon@mail.escuelaing.edu.co 4. Doctor en Informática; profesor asistente, Escuela Colombiana de Ingeniería Julio Garavito. Correo electrónico: daniel.diaz@escuelaing.edu.co 5. Especialista en Seguridad Informática; jefe División de Ciberdefensa, Dirección de Cibernética Naval. Armada Nacional. Correo electrónico: juan. garciaru@armada.mil. co A+T AcTuAlidAd TecnologicA INTELIGENCIA DE FUENTES AbIERTA (OSINT) PARA OPERACIONES DE CIbERSEGURIDAD.
Investigation of structural problems on the ground and walls of Diyarbakir Historical Behram Pasha Mosque by the georadar (GPR) method

Behram Pasha Mosque is one of the historical mosques, which is the work of Mimar Sinan [1], located in the southwest of Diyarbakır’s Suriçi Region. Georadar (GPR) method is one of the geophysical applications in which possible gaps, fractures, collapses, etc. damages are determined non-destructively on the walls and floors of historical buildings. Therefore, in one of the historic mosques in Diyarbakir Behram Pasha Mosque, expert geophysical engineers carried out the GPR scanning of the grounds and walls without damaging the mosque’s physical structure. In GPR surveys, the depth of investigation (penetration) was chosen as 20 m on the ground and 4 m on the wall. It is aimed to show the anomaly structures in the study area and its immediate surroundings due to the determination of the underground void structures and the continuity of the surface fractures at the research depth. In GPR studies, it has been determined that there are cracks and fractures on the walls of the mosque, of which the smallest was 12 cm and the largest was 40 cm, water leakage on the ground, deterioration due to corrosion, and partial collapses. The regions with the detected deformations are marked on the radar sections. The study was completed with the thought that the determined structural problems will contribute to the restoration and strengthening works to be done in the future in the mosque as an up-to-date guide.
Experimental Assessment of IEEE 802.11-based V2I Communications

Connected and automated vehicles are becoming a reality, and the necessity of assessing the performance of their technical enablers plays a pivotal role in the automotive field. Several technologies have been proposed by different standardization bodies, with the aim of enabling the connectivity between vehicles, and between vehicles and the infrastructure. Before the deployment of any technology, it is fundamental to perform a testing and validation phase, which is often performed in simulation environments. However, in order to assess the actual performance of a V2X (Vehicle-to-Everything) communication technology, field tests are of utmost importance. In this paper, we present the results of an extensive field test campaign of non-mmWave and mmWave IEEE 802.11 technologies for V2I (Vehicle-to-Infrastructure) communications, namely, IEEE 802.11p, IEEE 802.11ac, and IEEE 802.11ad. We assess the performance of each of them, in terms of connection stability, received signal level, Round Trip Time and UDP throughput, in both Line-Of-Sight and Non-Line-Of-Sight conditions. Our results show that, although not specifically designed for vehicular communications, IEEE 802.11ac and IEEE 802.11ad emerge as very promising technologies.
Ordering of Huge Biometric Information in Database System

The word biometrics is derived from the Greek words 'bios' and 'metric' which means living and calculation appropriately. Biometrics is the electronic identification of individuals based on their physiological and biological features. Biometric attributes are data take out from biometric test which can be used for contrast with a biometric testimonial. Biometrics composed methods for incomparable concede humans based upon one or more inherent material or behavioral characteristics. In Computer Science, bio-metrics is employed as a kind of recognition access management and access command. Biometrics has quickly seemed like an auspicious technology for attestation and has already found a place in the most sophisticated security areas. A systematic clustering technique has been there for partitioning huge biometric databases throughout recognition. As we tend to are still obtaining the higher bin-miss rate, so this work is predicated on conceiving an ordering strategy for recognition of huge biometric database and with larger precision. This technique is based on the modified B+ tree that decreases the disk accesses. It reduced the information retrieval time and feasible error rates. The ordering technique is employed to proclaims a person’s identity with a reduced rate of differentiation instead of searching the whole database. The response time degenerates, further-more because the accuracy of the system deteriorates as the size of the database increases. Hence, for vast applications, the requirement to reduce the database to a little fragment seems to attain higher speeds and improved accuracy.
LPG Delivery Sequencing for Real-Time Continuous Incoming Purchasing Orders

The research study presents a developed calculation algorithm for delivery sequencing for real-time purchasing orders in LPG (Liquefied Petroleum Gas) delivery business in Thailand. In practice, customers call the LPG call center requesting services and each customer’s order mostly requires an immediate service. Then routing and scheduling is done in real time. That the delivery provider needs to make a decision all the time due to the incoming orders are increasing making things more complicated in routes and schedules. As a result, the delivery cannot determined well enough in an appropriate time period. Hence, the objective of this study is to develop a sequential delivery calculation algorithm for LPG Delivery in real-time continuous incoming purchasing orders for calculating an appropriate total distance and reducing lead time before dispatching. This algorithm has been developed for sequencing and routing a fleet of vehicles from a distribution center (DC) to multiple delivery points. The vehicle routing method applies heuristics techniques on vehicle capacities and distances to minimize the travel distance and do the sequencing by on a real time basis. The system is divided into 3 phases. The first phase is to collect the gradually incoming data for calculation. As soon as a customer orders LPG, the system uses the Google MAP API for generating a distance data matrix to calculate the distance between customer’s location and the depot. The second phase is order assignment under the restriction; vehicle capacity and distances between routes and mapping out an appropriate route by using Nearest Neighbor Heuristics and 2-opt improvement. Finally, the third phase is to schedule the dispatches. The significance of the sequencing system is that it is all executed in real time. The findings in the research can be used by integrating the system to help the involved users in reducing the decision-making time for efficient routing, leading to less lead time before dispatching goods, having an efficient fleet control, and a right in time delivery with an appropriate total distance. To summarize, the system provides significantly better routes than those determined manually.
Temporal changes in unisexual and sexual Ambystoma salamander populations in southeast Michigan

Climate change drives changes in organisms’ geographic ranges that can lead to shifts in population structure. Unisexual (all female) Ambystoma salamanders reproduce via kleptogenesis, resulting in ploidy-variable offspring. I analyzed genetic data of historic and modern-day unisexual and A. laterale samples from the University of Michigan’s E. S. George Reserve using epidermal cell nuclei measurements and microsatellite loci. I found that population composition has shifted away from the more northern-distributed A. laterale and toward populations dominated by unisexuals in five out of six ponds. There was a significant relationship between the proportion of A. laterale to unisexuals and pond size but not between the proportion of A. laterale and mean and maximum temperature, or canopy cover. Changes in population composition could help reveal the susceptibility of amphibians to climate change and whether adaptation can keep pace with rapid environmental change.