Miracle-dz/UniFAR-FTUs huggingface dataset:
Global Landslide Forecasting System for Hazard Assessment and Situational Awareness

Landslides triggered by extreme rainfall can be devastating, resulting in loss of life, property, and infrastructure. Landslide forecasting systems provide an opportunity to build awareness of potential hazards and ultimately take preemptive measures. There is currently a dearth of forecasting systems that provide regional or global coverage, but these systems can offer important situational awareness in data-sparse, ungauged, or large-scale catchments. A near global, primarily satellite-based system called the Landslide Hazard Assessment for Situational Awareness (LHASA) provides near real-time estimates of potential landslide hazard and exposure around the world. In this work, a precipitation forecast module is introduced into LHASA to complement the existing LHASA framework and provide an estimate of landslide hazard up to 3 days in advance at 1 km resolution. The model-based Goddard Earth Observing System-Forward Processing (GEOS-FP) precipitation forecast product is used as the forcing input for the model in place of the satellite-based Integrated Multi-satellitE Retrievals for Global Precipitation Mission product. Soil moisture and snow depth from the GEOS-FP assimilated product are also incorporated. The study period January 2020–January 2021 is used to test the model performance against the LHASA near real-time estimates at multiple spatiotemporal scales. Validation of the model is carried out using a collection of rainfall-triggered landslide inventories from around the world as case studies to demonstrate the potential utility and limitations of this system. The rescaling of the GEOS-FP precipitation product is a critical step in incorporating the forecasted precipitation data within LHASA-Forecast (LHASA-F). Combining different streams of forecasted data within the LHASA-F framework shows promise, particularly for larger events at the 1- and 2-days lead time for events. Results indicate that for the case studies evaluated, the LHASA-F is generally able to resolve major landslide events triggered by extreme rainfall, such as from tropical cyclones. The analysis shows that landslide forecast outputs may be represented differently depending on the user’s needs. This framework serves as a first milestone in providing a global predictive view of landslide hazard.
Mutations in cye-1, a Caenorhabditis elegans cyclin E homolog, reveal coordination between cell-cycle control and vulval development

required maternally, but not zygotically for embryonic development. Our analysis of vulval development in cye-1 mutants suggests that a timing mechanism may control the onset of vulval cell terminal differentiation: once induced, these cells appear to differentiate after a set amount of time, rather than a speciﬁc number of division cycles. cye-1 mutants also show an increase in the percentage of vulval precursor cells (VPCs) that adopt vulval cell fates, indicating that cell-cycle length can play a role in the proper patterning of vulval cells. By analyzing cul-1 mutants, we further demonstrate that vulval cell terminal differentiation can be uncoupled from associated changes in vulval cell division planes.
Scientific Issues Treated in the Websites of Jordanian Universities Analytical study

: With the spread of Internet the information is becoming available any time anywhere that produces a large quantity of information available to the user in an easy manner. This huge volume of information available is produced at the cost of information quality. The websites is considered the first interface from which the user can obtain the information, it is an information system that collects and distributes the information. This paper presents a survey of the content of Jordanian universities websites, the goal of this research is to explore how the universities websites can handle the scientific events like conferences, seminars…. etc., to identify if the wide spread of information has influenced in the quality of content of Jordanian universities websites. And to show if the university website reflects the universities mission and objectives. Our research were based on the methodology of survey using content analysis style for 14 universities private and governmental, the questionnaire were composed on 21 variables that includes units and categories of analysis able to measure what is found, where is reviewed by a set of specialists reviewers. Our results show that there is a high competition between universities in making the university website more attractive for the user without taking in consideration the scientific content of the site.
Coherent Sheaves on Singular Projective Curves with Nodal Singularities

We give the full answer to the question: on which curves the category of coherent sheaves $\Coh_{X}$ is tame. The answer is: these are just the curves from the list of Drozd-Greuel. Moreover, in this case the derived category $D^{-}(\Coh_{X})$ is also tame. We give an explicit description of the objects of this category as well as of the categories $D^{b}(\Coh_{X})$, $\Coh_{X}$. Among the coherent sheaves we describe the vector bundles, torsion-free sheaves, mixed sheaves and skyscraper sheaves.
The number of simultaneous core partitions

Amdeberhan conjectured that the number of $(t,t+1, t+2)$-core partitions is $\sum_{0\leq k\leq [\frac{t}{2}]}\frac{1}{k+1}\binom{t}{2k}\binom{2k}{k}$. In this paper, we obtain the generating function of the numbers $f_t$ of $(t, t + 1, ., t + p)$-core partitions. In particular, this verifies that Amdeberhan's conjecture is true. We also prove that the number of $(t_1,t_2,., t_m)$-core partitions is finite if and only if gcd$(t_1,t_2,., t_m)=1,$ which extends Anderson's result on the finiteness of the number of $(t_1,t_2)$-core partitions for coprime positive integers $t_1$ and $t_2$ and thus rediscover a result of Keith and Nath with a different proof.
Three-dimensional dynamic rupture simulations across interacting faults: The M w 7.0, 2010, Haiti earthquake

The mechanisms controlling rupture propagation between fault segments during a large earthquake are key to the hazard posed by fault systems. Rupture initiation on a smaller fault sometimes transfers to a larger fault, resulting in a signiﬁcant event (e.g., 2002 M 7.9 Denali USA and 2010 M 7.1 Darﬁeld New Zealand earthquakes). In other cases rupture is constrained to the initial fault and does not transfer to nearby faults, resulting in events of more moderate magnitude. This was the case of the 1989 M 6.9 Loma Prieta and 2010 M 7.0 Haiti earthquakes which initiated on reverse faults abutting against a major strike-slip plate boundary fault but did not propagate onto it. Here we investigate the rupture dynamics of the Haiti earthquake, seeking to understand why rupture propagated across two segments of the Léogâne fault but did not propagate to the adjacent Enriquillo Plantain Garden Fault, the major 200 km long plate boundary fault cutting through southern Haiti. We use a ﬁnite element model to simulate propagation of rupture on the Léogâne fault, varying friction and background stress to determine the parameter set that best explains the observed earthquake sequence, in particular, the ground displacement. The two slip patches inferred from ﬁnite fault inversions are explained by the successive rupture of two fault segments oriented favorably with respect to the rupture propagation, while the geometry of the Enriquillo fault did not allow shear stress to reach failure.
Review of Shape-based Similarity Algorithms and Design Retrieval Methods for Computer-aided Design and Manufacturing

— Reusing engineering data has opened a new opportunity to improve product quality, shorten design lead-time and reduce costs using existing know-how within the design process. Geometrical aspects or 3D shape information of a product is an essential data which can be reused in CAD software. In order to compare and retrieve the existing 3D models, having a precise computational representation of a shape, so-called shape index or shape signature, is a main challenge. The shape signature is often used for the shape similarity comparison. There are several specifications for a shape signature like quick to compute, easy to index, invariant under transformation, independent of 3D representations, tessellation, genus or topology. The algorithms or the methods which decompose a shape into a signature can be classified into seven main classes. This paper aims to focus on the discussion of the first three methods, i.e., Invariant-based methods, Harmonics-based methods, and Graph-based methods, and provide the related literature review on their underlying approaches with highlighting methodologies, advantages and disadvantages.
Integrin 2 b Depends on Plasma Cells from Peripheral Lymph Nodes Cutting Edge: Egress of Newly Generated

During humoral immune responses, naive B cells differ-entiate into Ab-secreting plasma cells within secondary lymphoid organs. Differentiating plasma cells egress from their sites of generation and redistribute to other tissues, predominantly the bone marrow and mucosal tissues. In this study, we demonstrate that within peripheral lymph nodes newly generated plasma cells localize to medullary cords which express the (cid:1) 2 integrin ligand ICAM-1. In (cid:1) 2 integrin-deficient mice plasma cells accumulate inside the lymph nodes, resulting in severely reduced plasma cell numbers in the bone marrow. Since plasma cells isolated from (cid:1) 2 integrin-deficient animals migrate efficiently into the bone marrow when transferred i.v. , our findings provide profound evidence that (cid:1) 2 integrins are required for the egress of plasma cells from peripheral lymph nodes. The Journal of Immunology, 2005, 174: 7492–7495.
DMSO_A_274844 4763..4777

Pharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia Abstract: Diabetes mellitus (DM) is a chronic endocrine disease distinguished by hyperglycemia due to disturbance in carbohydrate or lipid metabolism or insulin function. To date, diabetes, and its complications, is established as a global cause of morbidity and mortality. The intended aim during the management of diabetes is to maintain blood glucose close to normal because the majority of patients have poor control of their elevated blood glucose and are highly prone to severe macrovascular and microvascular complications. To decrease the burden of the disease and its complications, scientists from various disciplines are working intensively to identify novel and promising drug targets for diabetes and its complications. Increased and ongoing investigations on mechanisms relating to diabetes and associated complications could potentially consider inflammatory cascades as a promising component of the strategy in the prevention and control of diabetes and its complications. The potential of targeting mediators of inflammation like toll-like receptors (TLRs) are part of current investigation by the scientific community. Hence, the aim of the present review is to discuss the role of TLRs as a potential drug target for diabetes and diabetes associated complications.
Repression of p27 kip1 Synthesis by Platelet-Derived Growth Factor in BALB/c 3T3 Cells

We have investigated the regulation of p27 kip1 , a cyclin-dependent kinase inhibitor, in BALB/c 3T3 cells during growth factor-stimulated transition from quiescence (G 0 ) to a proliferative (G 1 ) state. The level of p27 kip1 protein falls dramatically after mitogenic stimulation and is accompanied by a decrease in cyclin E associated p27 kip1 , as well as a transient increase in cyclin D1-associated p27 kip1 that later declines concomitantly with the loss of total p27 kip1 . Analysis of metabolically labelled cells revealed that cyclin D2, cyclin D3, and cdk4 were also partnered with p27 kip1 in quiescent BALB/c 3T3 cells and that this association decreased after platelet-derived growth factor (PDGF) treatment. Furthermore, the decline in p27 kip1 and reduced association with cyclin D3, initiated by the addition of PDGF but not plasma-derived factors, suggested that these changes are involved in competence, the ﬁrst step in the exit from G 0 . Synthesis of p27 kip1 as determined by incorporation of [ 35 S]methionine was repressed upon mitogenic stimulation, and PDGF was sufﬁcient to elicit this repression within 2 to 3 h. Pulse-chase experiments demonstrated the reduced rate of synthesis was not the
Identi cation and Validation of an RNA Binding Proteins-Associated Prognostic Signature for Non- Small Cell Lung Cancer

Ti-wei Miao sichuan university https://orcid.org/0000-0003-3705-1568 Fang-ying Chen Department of Tuberculosis, the Third People's Hospital of Tibet Autonomous Region, Lhasa, China Wei Xiao Respiratory Group, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China Long-yi Du Respiratory Group, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China Bing Mao Respiratory Group, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China Yan Wang Research Core Facility, West China Hospital, Sichuan University, Chengdu, China Juan-juan Fu (  fu.juanjuan@scu.edu.cn ) Respiratory Group, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China https://orcid.org/0000-0002-7957-1409
ANALYSIS OF COMBINATION OF NALTREXONE WITH BUPROPION FOR WEIGHT LOSS

: An estimated 34% of American adults were obese, and an additional 34% were overweight in 2007 – 2008. Obesity is associated with diabetes, hypertension, hyperlipidemia, stroke, heart disease, respiratory problems, osteoarthritis, and several types of cancer. The basic aim of the study is to analyze the combination of naltrexone with bupropion for weight loss. Obesity is associated with alterations in neural signaling. Differences in neural responses to hunger and satiation are documented in obese vs. lean individuals and women appear to exhibit lower cognitive control of brain responses to food stimuli than men. Naltrexone is reformulated as a sustained release (SR) dosage form in this combination product, which has bioequivalent exposure to naltrexone immediate release (IR). Naltrexone/bupropion should be used with caution in patients who are elderly or have moderate or severe renal impairment. It should be avoided in patients with severe hepatic disease. Bupropion reduces short-term food intake in lean and obese rodent models and increases energy expenditure by increasing heat production, although the overall effect of bupropion on body weight in animals is modest. It is concluded that naltrexone/bupropion is an effective agent for weight management. Further studies are necessary to determine the effect of naltrexone/ bupropion on cardiovascular outcomes.
Evolving Absorptive Capacity: The Mediating Role of Systematic Knowledge Management

Absorptive capacity is mediated through knowledge management capacity on innovation output and performance in technology-oriented firms. While prior research work has focused on the direct effect of absorptive capacity on innovation, in this paper, our model posits that absorptive capacity is more efficient in promoting firms’ innovation provided that it is supported by systematic knowledge management practices. We tested this model that included all four components of absorptive capacity using a sample of 127 manufacturing and technology firms in Croatia. Structural equation modeling procedures were used to test hypotheses. Our findings confirm the significance of the relationship between absorptive capacity and knowledge management within firms. Furthermore, we found that firms with higher acquisition and transformation dimensions of absorptive capacity can enhance and replenish their knowledge management practices, which in return result in higher innovation output. These findings extend previous research work by explaining the sometimes-contradictory findings concerning knowledge management practices, which firms may adopt to enhance their absorptive capacity.
Effects of high-intensity interval training and plyometric exercise on the physical fitness of junior male handball players.

OBJECTIVE This study analyzed the effects of high intensity interval training (HIIT) combined with plyometric exercise on the physical fitness of junior male handball players. PATIENTS AND METHODS Subjects (age ~17 years) were randomly divided between experimental (n=17) and control (n=15) groups. During the 8-week intervention, the experimental group replaced a part of their regular regimen by HIIT, combined with plyometric exercise. Assessments in both groups before and after the intervention included: squat jump (SJ), countermovement jump (CMJ), sprint performance (5 m, 10 m, 20 m and 30 m), change of direction tests (Illinois modified test [Illinois-MT] and T-half test), 20-m shuttle run, and repeated sprint T-test. RESULTS The two-way analyses of variance revealed significant group-time interactions (all p<0.05), favoring the intervention group in 5 m, 10 m, 20 m and 30 m sprint (d=0.33, 8.3%; d=0.52, 7.6%; d=0.57, 6.8%; and d=0.58, 8.8%, respectively), T-half (d=0.25, 5.1%), Illinois-MT (d=0.47, 4.2%), SJ and CMJ (d=0.34-0.39, 34-4-34.9%), repeated sprint T-test best time, mean time and total time (d=0.83, 6.9%; d=0.62, 7.4%; and d=0.61, 7.2%, respectively), 20 meter shuttle run test aerobic maximum speed and predicted maximal oxygen intake (d=0.36, 7.5%; d=0.19, 9.4%, respectively). CONCLUSIONS HIIT combined with plyometrics can aid in the development of physical fitness abilities, which are extremely important to junior male handball players.
Activity and High IL-2 Production Effector CD8 T Cells with Low Cytotoxic Brief Antigenic Stimulation Generates

It is currently believed that a brief antigenic stimulation is sufﬁcient to induce CD8 T cells to complete their differentiation program, become effector T cells, and subsequently generate memory. Because this concept was derived from studies in which only a single effector function was analyzed (either IFN- (cid:1) production or target cell lysis), we wondered whether monitoring for multiple effector functions might reveal novel characteristics of effector CD8 T cells elicited by brief or prolonged Ag exposure. Using an in vitro system to generate effector T cells and an in vivo adoptive transfer model to track donor CD8 T cells, we found that the differentiation programs acquired by CD8 T cells after brief or prolonged antigenic stimulation were different. Although the frequencies of IFN- (cid:1) and TNF- (cid:2) producers were comparable for both effector CD8 T cell populations, there were major differences in cytotoxic potential and IL-2 production. Whereas prolonged ( > 24 h) Ag exposure stimulated effector CD8 T cells with high cytotoxic activity and low IL-2 production, brief ( < 24 h) stimulation generated effector CD8 T cells with low cytotoxic activity and high IL-2 production. The latter effector T cells rapidly converted into central memory-like CD8 T cells, exhibited long-term survival in adoptively transferred hosts, and gave robust recall responses upon Ag challenge. These data suggest that not all functions of effector CD8 T cells are equally inherited after brief or prolonged antigenic stimulation. The Journal of Immunology, 2008, 180: 4507–4513.
Mouse Mast Cell Proteases 4 and 5 Epidermal Burn Depends on the Activities of The Inflammatory Response after an

A second-degree epidermal scald burn in mice elicits an inﬂammatory response mediated by natural IgM directed to nonmuscle myosin with complement activation that results in ulceration and scarring. We ﬁnd that such burn injury is associated with early mast cell (MC) degranulation and is absent in WBB6F1- Kit W /Kit Wv mice, which lack MCs in a context of other defects due to a mutation of the Kit receptor. To address further an MC role, we used transgenic strains with normal lineage development and a deﬁciency in a speciﬁc secretory granule component. Mouse strains lacking the MC-restricted chymase, mouse MC protease (mMCP)-4, or elastase, mMCP-5, show decreased injury after a second-degree scald burn, whereas mice lacking the MC-restricted tryptases, mMCP-6 and mMCP-7, or MC-speciﬁc carboxypeptidase A3 activity are not protected. Histologic sections showed some disruption of the epidermis at the scald site in the protected strains suggesting the possibility of topical reconstitution of full injury. Topical application of recombinant mMCP-5 or human neutrophil elastase to the scalded area increases epidermal injury with subsequent ulceration and scarring, both clinically and morphologically, in mMCP-5–deﬁcient mice. Restoration of injury requires that topical administration of recombinant mMCP-5 occurs within the ﬁrst hour postburn. Importantly, topical
A Genetic Algorithm with Online Learning Approach for Improving Loop Closure Detection of a Visual SLAM

This paper presents a genetic algorithm with online learning approach for improving loop closure detection of a visual simultaneous localisation and mapping (SLAM) technique. The reality gap issue in evolutionary robotics field is known as the main factor that degrades the quality of simulated solutions when transferring to a real robot. The proposed method can optimise the parameter of a visual SLAM in real-time. The aim is to evolve and search for the best Bayes filter parameters of the loop closure detection using online data gathered directly from a connected robot. A fitness function calculation utilising real-time images and robot motion is proposed to evaluate the performance of candidate solutions throughout the learning session. The experimental results show that SLAM with the optimised loop closure detection parameters outperforms SLAM with the default parameters for about 90% improvement.
Institutional Knowledge at Singapore Management University Content sampling, household informedness, and the consumption of digital information goods

Mellon. interdisciplinary research spans strategy, information, information technology, economics, marketing and consumer behaviour, the fintech revolution, environmental sustainability, and computational social science and data analytics. He is a frequent keynote speaker on these subjects. His research has appeared in Management Science, Information Systems Research, Journal of Management Information Systems, MIS Quarterly, Organization Science , and the Review of Economics and Statistics , among others. ABSTRACT: Technology and media are delivering content that is transforming society. Providers must compete for consumer attention to sell their digital information goods effectively. This is challenging, since there is a high level of uncertainty associated with the consumption of such goods. Service providers often use free programming to share product information. We examine the effectiveness of content sampling strategy used for on-demand series dramas, a unique class of entertainment goods. The data were extracted from a large set of household video-on-demand (VoD) viewing records and combined with external data sources. We extended a propensity score matching (PSM) approach to handle censored data, which us to explore the main causal relationships. Relevant theories in the and our research on for the of and for The results show that content they have to offer. Next, we discuss the implications for service providers for their use of sampling-based strategies. of the Integrating Business Operations, and