Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of natural products on developing new anti-cancer agents.

3.3. 1. Potential of the “Metagenome” 3016 3.3. 2. Cryptic Clusters in Bacteria and Fungi 3016 3.3.3. Cyanophytes 3017 3.3. 4. Marine Microbes (Non-Cyanophytes) 3018 3.3. 5. Extremophiles 3018 3.3. 6. Microbial Symbionts 3019 3.3. 7. Plant Endophytes 3020 3.3. 8. Combinatorial Biosynthesis 3020 4. Development of Drugs from Natural Products 3020 4.1. Synthesis Based on Natural Products 3021 4.1. 1. Derivatization and Semisynthesis 3021 4.1. 2. Total Synthesis 3021 4.1. 3. Diverted Total Synthesis 3021 4.2. Natural Product-Inspired Combinatorial Synthesis 3022
A COMPARISON OF VISUAL INTERPRETATION AND OBJECT BASED IMAGE ANALYSIS FOR DERIVING LANDSCAPE METRICS

Remote sensing systems have been widely used for several ecological applications. Great part of research in landscape ecology uses visual interpretation because it is flexible and efficient at extracting spatial information. But this method demands more time to be accomplished. Semi-automatic classification provided very high automaticity and needs less time, but it is not suitable for accurately classifying all classes of interest. Geographic object-based image analysis – GEOBIA has been used to achieve better results regarding classification quality. Thus, in this study we aim to verify if landscape metrics derived from visual interpretation differ significantly from the ones derived using GEOBIA. We used a 2.5 m resolution HCR SPOTMaps product to perform two different classifications: visual interpretation (VI) and object-based classification (OBC), using SPRING 5.1. 5 and eCognition 8, respectively. Landscape metrics were calculated using FRAGSTATS 3.1, and compared using Pearson’s chi-squared (χ2) statistics (p<0.05). We found that VI demanded more processing time when compared to OBC. Nevertheless, VI showed higher accuracy (kappa=0.92; Figure 1) than the OBC (kappa=0.74; Figure 2). There were significant difference between some landscape metrics derived from VI and OBC. Different mapping strategies based on satellite imagery can affect the measurement of landscape metrics, compromising their ecological meaning. It is important to consider the classification method when performing landscape ecology studies, in order to avoid misinterpretations and induce decision makers to develop erroneous conservation actions. This study allowed us to visualize the importance of choosing higher accuracy mapping, providing a better understanding of landscape metrics. * Corresponding author.
Lattice dynamics of $\textit{Pnma}$ Sn(S$_{1-x}$Se$_{x}$) solid solutions: energetics, phonon spectra and thermal transport

Alloying is widely used as a means to fine-tune the properties of thermoelectric materials by reducing the lattice thermal conductivity. However, the effects of compositional variation on the lattice dynamics of alloy systems are not well understood, due in part to the difficulty of building realistic first-principles models of structurally-complex solid solutions. This work builds on our previous study of Sn$_{n}$(S$_{1-x}$Se$_{x}$)$_{m}$ solid solutions [Gunn $\textit{et al.}$, $\textit{Chem. Mater. }$ $\textbf{31}$, $\textit{10}$, 3672, $\textbf{2019}$] to explore the lattice dynamics of the $\textit{Pnma}$ Sn(S$_{1-x}$Se$_{x}$) system, which has been widely studied for potential thermoelectric applications. We find that the vibrational internal energy and entropy have a large quantitative impact on the mixing free energy and are likely to be particularly important in alloy systems with competing phases. The thermodynamically-averaged phonon dispersions and density of states curves show that alloying preserves the structure of the low-frequency bands of modes associated with the Sn sublattice but broadens the high-frequency chalcogen bands into a near-continuous spectrum at the 50/50 mixed composition. This results in a general reduction in the phonon mode group velocities and an increase in the number of energy-conserving scattering channels for heat-carrying low-frequency modes, which is consistent with the decrease in thermal conductivity observed in experimental measurements. Finally, we discuss some of the limitations of our first-principles modelling approach and propose methods to address these in future studies.
Integration Of Content Size Adjustment And Caching Policy to Improve Named Data Networking Performance

In-network caching is an important part of future network design. One of the future networks that have a caching function in the network is Named Data Networking (NDN). All NDN nodes can store content in their content store. Therefore, it can reduce the latency of content retrieval by the user. The caching function can cope with the increase in big data traffic, such as video, which is predicted to dominate more than 79% of traffic on the network. Caching on NDN offers a solution by sending large content into smaller chunks of content, but there is no specific standard for setting the right chunk size. In this paper, we conduct an in-depth evaluation of chunk size allocation in NDN content stores and collaborate with several caching strategies. The test was carried out at the emulation level using Mininet-NDN. The study's results prove that sending chunk-size content can improve NDN performance compared to full-size content. The first topology shows that the transmission delay decreases when sending content chunks. Then the Cache Hit Ratio (CHR) obtained is higher than sending full-size content. In the second topology, uniform and various content size adjustments show promising results when using the Leave Copy Everywhere (LCE) cache strategy.
Master Therapists: Exploring Expertise in Therapy and Counseling

Dedication. List of Tables and Figures. Foreword. Preface. Searching for Mastery. 1. A Brief History of Expertise. 2. Expertise in Therapy and Counseling. 3. The Cognitive, Emotional, and Relational Characteristics of Master Therapists. 4. Master Therapists Construction of the Therapy Relationship. 5. Emotional Wellness and Professional Resiliency of Master Therapists. 6. Ethical Values of Master Therapists. 7. Portrait of the Master Therapist: The Highly Functioning Self. 8. Qualitative Research Methodologies. Respondents: Sample Selection. Jennings and Skovholt's Methodology (Chapter 3). Sullivan, Skovholt, and Jennings's Methodology (Chapter 4). Mullenbach and Skovholt's Methodology (Chapter 5). Jennings, Sovereign, Bottorff, and Mussell's Methodology (Chapter 6). Appendix A. Interview with Master Therapist #1 (Len Jennings). Interview with Master Therapist #2 (Michael Sullivan). Interview with Master Therapist #3 (Mary Mullenbach). Index.
Nest predation and brood parasitism of tallgrass prairie birds

Rates of nest predation and brood parasitism on 5 bird species nesting in fragments of tallgrass prairies in Minnesota were affected by the size of the prairie fragment containing the nest, the distance from the nest to a wooded edge, and the number of growing seasons since the vegetation around the nest was last burned. Rates of nest predation for 5 species were lower (P < 0.10 in each case) for nests on large (-130 ha) fragments, in areas far (? 45 m) from a wooded edge, and in vegetation that was recently burned (s3 yr). Rates of brood parasitism were lower (P < 0.10 in each case) far from a wooded edge. Prairie management to maximize nest productivity should provide large, regularly burned prairies with no nearby wooded edges. J. WILDL. MANAGE. 54(1):106-111 More than 99% of the presettlement tallgrass prairie in Minnesota has been converted to agriculture and other uses. Remnant tracts of prairie are usually small, isolated parcels surrounded by habitat unsuitable for most prairie birds. Many of the remaining prairie fragments contain invading tree species, such as aspen (Populus tremuloides) and willow (Salix spp.), and/ or cottonwood (Populus deltoides) shelterbelts. Natural fires, once common occurrences in the tallgrass prairie (Daubenmire 1968), are suppressed, but prescribed burning is now a major management activity on native prairies. Several animals that depredate or parasitize nests of prairie birds have recently increased in abundance in western Minnesota. For example, raccoons (Procyon lotor), nest predators once limited to southeastern Minnesota, have expanded their range into the prairie region and are now common (Hazard 1982). Densities of red fox (Vulpes vulpes) have increased due to changes in agricultural practices and the reductions of other canids (Johnson and Sergeant 1977). In addition, brown-headed cowbirds (Molothrus ater), an obligate brood parasite, have greatly increased in abundance since 1900 (Brittingham and Temple 1983). Currently, most management of prairie fragments is undertaken to perpetuate native plant communities, but little is known about how vegetation management affects breeding bird populations on prairies. Consequently, we studied the effects of nest predation and brood parasitism on the productivity of birds nesting in managed tallgrass prairies in western Minne-
The reproductive biology and spawning behaviour of Chromis hypsilepis (Pisces: Pomacentridae)

Masters Research - Master of Philosophy (MPhil)%%%%Fishes of the family Pomacentridae utilize a great range of reproductive strategies, although most research has focussed on tropical species. Chromis hypsilepis is a schooling planktivore that occurs on temperate rocky reefs from northern New South Wales to northern Tasmania. During the summer breeding season, large numbers of C. hypsilepis migrate to spawning aggregation sites. This spawning strategy is unusual in the family Pomacentridae and demersal spawning is very uncommon among fishes that form spawning aggregations. This study was undertaken to fill the gap in understanding of the reproductive biology of C. hypsilepis and to provide detailed descriptions of the reproductive behaviour as part of improving the understanding of this unusual reproductive strategy. Age, growth, sexual maturity and reproductive behaviour of C. hypsilepis were described from a population at Terrigal, New South Wales. The length and age at sexual maturity were also compared to a population at Jervis Bay, 200 km south of Terrigal. C. hypsilepis is gonochoristic and occurred in a 1:1 sex ratio. The use of bands in the sagittal otoliths of C. hypsilepis as a measure of age was validated with marginal increment analysis. A maximum age of 22.5 years was recorded. Males and females, respectively, attained sexual maturity at 75.2 and 89.2 mm SL at Terrigal, corresponding to ages of 1.9 and 2.0 years. Von Bertalanffy growth models showed that males and females attained 50% of their asymptotic length within 1-2 years. There was minimal variation between the Terrigal and Jervis Bay populations. Spawning behaviour was described using mounted underwater video cameras, recording up to 11 hours per day. Spawning was acyclic. Spawning occurred throughout the day, building up during the morning hours to a peak at midday and dramatically dropping in frequency throughout the rest of daylight hours. The results of this study are a necessary component of understanding the unique reproductive strategy of C. hypsilepis.
Review Article Minireview on the Connections between the Neuropsychiatric and Dental Disorders: Current Perspectives and the Possible Relevance of Oxidative Stress and Other Factors

Department of Research, Faculty of Biology, “Alexandru Ioan Cuza” University of Iasi, Carol I Avenue, 20A, Iasi, Romania Faculty of Medicine, “Gr. T. Popa” University of Medicine and Pharmacy, 16th University Street, Iasi, Romania Department of Biology, Faculty of Biology, “Alexandru Ioan Cuza” University of Iași, Bd. Carol I, 20A, 700505 Iași, Romania Department of Oral Science, Matsumoto Dental University, Shiojiri, Japan
CDA Linguistic Imperialism and CPEC: A Hegemonic View of the Emergence of a New Lingua Franca in the Region

CPEC (China Pakistan Economic Corridor), a hot cake for the analysts, business Tycons, politicians, traders and above all the common person. CPEC has become the centre of attention for the whole world as it has been entitled as “a game changer”, since Chine is getting access to a big economy of the European and Gulf states through. Gawader has become a Global eye catcher. This issue is being manipulated and portrayed in different colours on the national and international forums. The present study has been invested to explore its effect on the linguistic map of the world generally and Pakistan particularly. The present explores the prospects of CPE as creating new linguistic changes and its hegemonic acceptance. It is an analytical research of media discourse to expose the manipulation of social power and inequality on national, regional and global levels being reflected through text and talk in both social and political contexts. CDA has been used as a methodology to unveil the biased language and to make the readers aware of manipulations strategies. The present study aims at make a critical discourse analysis of BBC (British Broadcast Company) Kuala Lumpur‘s report published on 22nd February 2012 to investigate the manipulative strategy of the editor that how CPEC can be involved in a linguistic debate on global level and how it can disturb the linguistic imperialism. To meet this purpose a journal with the title of “ Is English or Mandarin the language of the future? ” published in BBC Kuala Lumpur has been selected to be analysed on the modal of Van Dijk (2000) in terms of discursive strategies The nature of the study is both quantitative and qualitative. The results are shown through numbers and tables to present clearer results. The results show a mixed approach towards the acceptance of the mega project and apprehensions of the stakeholders.
COVID-19: Oxidative Preconditioning as a Potential Therapeutic Approach

This Article summarizes the likely benefits of central nervous system oxidative preconditioning in the reduction of COVID-19 based on its putative pathogenesis. The current COVID-19 outbreak caused a pandemic with millions of infected patients and death cases worldwide. The clinical features of severe acute respiratory syndrome coronavirus (SARS-CoV) was initially linked with respiratory disorders, but recent studies have reported alterations of neurological and cerebrovascular functions in COVID-19 patients. The main viral infection features are related to cell death, inflammation, and cytokine generation, which can be associated with the dysregulation of redox systems or oxidative stress. However, until now, there is no available and effective therapeutic approach. Thus, it is necessary to search for care and adequate protection against the disease, especially for susceptible and vulnerable groups. Preconditioning, a well-known antioxidative stress and anti-inflammatory approach, is protective against many neurological age-related disorders. COVID-19 severity and morbidity have been observed in elderly patients. The aim of the present study is to elucidate the possible protective role of oxidative preconditioning in aged patients at high risk of developing severe COVID-19 complications.
Maintenance Of Mammary Epithelial Phenotype By Transcription Factor Runx1 Through Mitotic Gene Bookmarking

Breast cancer arises from a series of acquired mutations that disrupt normal mammary epithelial homeostasis and create multi-potent cancer stem cells that can differentiate into clinically distinct breast cancer subtypes. Despite improved therapies and advances in early detection, breast cancer remains the leading diagnosed cancer in women. A predominant mechanism initiating invasion and migration for a variety of cancers including breast, is epithelial-to-mesenchymal transition (EMT). EMT— a trans-differentiation process through which mammary epithelial cells acquire a more aggressive mesenchymal phenotype—is a regulated process during early mammary gland development and involves many transcription factors involved in cell lineage commitment, proliferation, and growth. Despite accumulating evidence for a broad understanding of EMT regulation, the mechanism(s) by which mammary epithelial cells maintain their phenotype is unknown. Mitotic gene bookmarking, i.e., transcription factor binding to target genes during mitosis for post mitotic regulation, is a key epigenetic mechanism to convey regulatory information for cell proliferation, growth, and identity through successive cell divisions. Many phenotypic transcription factors, including the hematopoietic Runt Related Transcription Factor 1 (RUNX1/AML1), bookmark target genes during mitosis. Despite growing evidence, a role for mitotic gene bookmarking in maintaining mammary epithelial phenotype has not been investigated. RUNX1 has been recently identified to play key roles in breast cancer development and progression. Importantly, RUNX1 stabilizes the normal breast epithelial phenotype and prevents EMT through repression of EMT-initiating pathways [9]. Findings reported in this thesis demonstrate that RUNX1 mitotically bookmarks both RNA Pol I and II transcribed genes involved in proliferation, growth, and mammary epithelial phenotype maintenance. Inhibition of RUNX1 DNA binding by a specific small molecule inhibitor led to phenotypic changes, apoptosis, differences in global protein synthesis, and differential expression of ribosomal RNA as well as protein coding genes and long non-coding RNA genes involved in cellular phenotype. Together these findings reveal a novel epigenetic regulatory role of RUNX1 in normallike breast epithelial cells and strongly suggest that mitotic bookmarking of target genes by RUNX1 is required to maintain breast epithelial phenotype. Disruption of RUNX1 bookmarking results in initiation of epithelial to mesenchymal transition, an essential first step in the onset of breast cancer.
LISAC FSDM-USMBA Team at SemEval-2020 Task 12: Overcoming AraBERT’s pretrain-finetune discrepancy for Arabic offensive language identification

AraBERT is an Arabic version of the state-of-the-art Bidirectional Encoder Representations from Transformers (BERT) model. The latter has achieved good performance in a variety of Natural Language Processing (NLP) tasks. In this paper, we propose an effective AraBERT embeddings-based method for dealing with offensive Arabic language in Twitter. First, we pre-process tweets by handling emojis and including their Arabic meanings. To overcome the pretrain-finetune discrepancy, we substitute each detected emojis by the special token [MASK] into both fine tuning and inference phases. Then, we represent tweets tokens by applying AraBERT model. Finally, we feed the tweet representation into a sigmoid function to decide whether a tweet is offensive or not. The proposed method achieved the best results on OffensEval 2020: Arabic task and reached a macro F1 score equal to 90.17%.
Study of the Stability of various Biochemical Analytes in Pooled Sera preserved at 4-8 o C

Biochemical laboratory plays an important role in today’s clinical practice. The reliability of laboratory results is therefore most important. Through the quality control (QC), errors can be minimized and the laboratory can ensure about the reliability of its results. The quality control sera are useful for this purpose. But commercially available quality control sera are costly and not available at all places. Also at peripheral levels the storage of the sera at very low temperature is not possible. So we have studied the stability of various biochemical analytes in the pooled sera stored in readily available refrigerator. We have collected 42.5 ml of pooled sera in a plastic jar and we have added 7.5 ml of ethanediol to it (15%). This pooled serum is tested for HIV and HBS Ag. Then serum is kept in the refrigerator at 4 – 8 o C . Daily 1-2 ml of the serum is taken in a plastic test tube with new micro pipette tip from the jar after thorough mixing. When serum attains the room temperature various tests were performed. The results of the tests were noted. We have compared these results with ERBA multi-calibrated sera We have studied 10 such pooled sera. We have found that total proteins and bilirubin get deteriorated (values varies more than 10%) early i.e. between 18-20 days in all 10 samples. Then alkaline phosphatase and amylase get deteriorated between 22-26 days. Glucose and albumin remain stable for 27-30 days. Cholesterol, triglycerides and uric acid starts deteriorating after 32 days. SGOT, SGPT, LDH deteriorates after 35 days. Urea, creatinine, calcium and phosphorus remain stable for long period i.e. more than 45 days.
Data Analytics Project Methodologies: Which One to Choose?

Developments in big data have led to an increase in data analytics projects conducted by organizations. Such projects aim to create value by improving decision making or enhancing business processes. However, many data analytics projects still fail to deliver the expected value. The use of process models or methodologies is recommended to increase the success rate of these projects. Nevertheless, organizations are hardly using them because they are considered too rigid and hard to implement. The existing methodologies often do not fit the specific project characteristics. Therefore, this research suggests grouping different project characteristics to identify the most appropriate project methodology for a specific type of project. More specifically, this research provides a structured description that helps to determine what type of project methodology works for different types of data analytics projects. The results of six different case studies show that continuous projects would benefit from an iterative methodology.
Fenchel-Young Losses with Skewed Entropies for Class-posterior Probability Estimation

We study class-posterior probability estimation (CPE) for binary responses where one class has much fewer data than the other. For example, events such as species co-occurrence in ecology and wars in political science are often much rarer than non-events. Logistic regression has been widely used for CPE, while it tends to underestimate the probability of rare events. Its main drawback is symmetry of the logit link—symmetric links can be misled by small and imbalanced samples because it is more incentivized to overestimate the majority class with finite samples. Parametric skewed links have been proposed to overcome this limitation, but their estimation usually results in nonconvex optimization unlike the logit link. Such nonconvexity is knotty not only from the computational viewpoint but also in terms of the parameter identifiability. In this paper, we provide a procedure to derive a convex loss for a skewed link based on the recently proposed FenchelYoung losses. The derived losses are always convex and have a nice property suitable for class imbalance. The simulation shows the practicality of the derived losses.