Miracle-dz/UniFAR-FTUs huggingface dataset:
Time-marching based quantum solvers for time-dependent linear differential equations

The time-marching strategy, which propagates the solution from one time step to the next, is a natural strategy for solving time-dependent differential equations on classical computers, as well as for solving the Hamiltonian simulation problem on quantum computers. For more general homogeneous linear differential equations ddt|ψ(t)⟩=A(t)|ψ(t)⟩,|ψ(0)⟩=|ψ0⟩, a time-marching based quantum solver can suffer from exponentially vanishing success probability with respect to the number of time steps and is thus considered impractical. We solve this problem by repeatedly invoking a technique called the uniform singular value amplification, and the overall success probability can be lower bounded by a quantity that is independent of the number of time steps. The success probability can be further improved using a compression gadget lemma. This provides a path of designing quantum differential equation solvers that is alternative to those based on quantum linear systems algorithms (QLSA). We demonstrate the performance of the time-marching strategy with a high-order integrator based on the truncated Dyson series. The complexity of the algorithm depends linearly on the amplification ratio, which quantifies the deviation from a unitary dynamics. We prove that the linear dependence on the amplification ratio attains the query complexity lower bound and thus cannot be improved in the worst case. This algorithm also surpasses existing QLSA based solvers in three aspects: (1) A(t) does not need to be diagonalizable. (2) A(t) can be non-smooth, and is only of bounded variation. (3) It can use fewer queries to the initial state |ψ0⟩. Finally, we demonstrate the time-marching strategy with a first-order truncated Magnus series, which simplifies the implementation compared to high-order truncated Dyson series approach, while retaining the aforementioned benefits. Our analysis also raises some open questions concerning the differences between time-marching and QLSA based methods for solving differential equations.
Synthesis of Semantic Actions in Attribute Grammars

Attribute grammars allow the association of semantic actions to the production rules in context-free grammars, providing a simple yet effective formalism to define the semantics of a language. However, drafting the semantic actions can be tricky and a large drain on developer time. In this work, we propose a synthesis methodology to automatically infer the semantic actions from a set of examples associating strings to their meanings. We also propose a new coverage metric, derivation coverage. We use it to build a sampler to effectively and automatically draw strings to drive the synthesis engine. We build our ideas into our tool, PĀNINI, and empirically evaluate it on twelve benchmarks, including a forward differentiation engine, an interpreter over a subset of Java bytecode, and a mini-compiler for C language to two-address code. Our results show that PĀNINI scales well with the number of actions to be synthesized and the size of the context-free grammar, significantly outperforming simple baselines.
Medical image analysis based on transformer: A Review

A BSTRACT The transformer has dominated the natural language processing (NLP) ﬁeld for a long time. Recently, the transformer-based method is adopt into the computer vision (CV) ﬁeld and shows promising results. As an important branch of the CV ﬁeld, medical image analysis joins the wave of the transformer-based method rightfully. In this paper, we illustrate the principle of the attention mechanism, and the detailed structures of the transformer, and depict how the transformer is adopted into the CV ﬁeld. We organize the transformer-based medical image analysis applications in the sequence of different CV tasks, including classiﬁcation, segmentation, synthesis, registration, localization, detection, captioning, and denoising. For the mainstream classiﬁcation and segmentation tasks, we further divided the corresponding works based on different medical imaging modalities. We include thirteen modalities and more than twenty objects in our work. We also visualize the proportion that each modality and object occupy to give the readers an intuitive impression. We hope our work can contribute to the development of transformer-based medical image analysis in the future.
Uni6Dv2: Noise Elimination for 6D Pose Estimation

Uni6D is the first 6D pose estimation approach to employ a unified backbone network to extract features from both RGB and depth images. We discover that the principal reasons of Uni6D performance limitations are Instance-Outside and Instance-Inside noise. Uni6D's simple pipeline design inherently introduces Instance-Outside noise from background pixels in the receptive field, while ignoring Instance-Inside noise in the input depth data. In this paper, we propose a two-step denoising approach for dealing with the aforementioned noise in Uni6D. To reduce noise from non-instance regions, an instance segmentation network is utilized in the first step to crop and mask the instance. A lightweight depth denoising module is proposed in the second step to calibrate the depth feature before feeding it into the pose regression network. Extensive experiments show that our Uni6Dv2 reliably and robustly eliminates noise, outperforming Uni6D without sacrificing too much inference efficiency. It also reduces the need for annotated real data that requires costly labeling.
When IS Success Model Meets UTAUT in a Mobile Banking Context: A Study of Subjective and Objective System Usage

The objective usage of mobile banking (MB) reflects more validated measure when compared to subjective usage. Although objective system usage has been seldom studied, it has been never investigated in a MB context to the best of our knowledge. This research in progress develops an integrative conceptual framework that incorporates relevant-context factors into well-established models of IS success and UTAUT to examine their direct and indirect effects on MB usage. This examination can expand our knowledge of system usage in the context of mobile banking. Contribution and implications are discussed
Comparative efficacy and safety of oral nifedipine with other antihypertensive medications in the management of hypertensive disorders of pregnancy: a systematic review and meta-analysis of randomized controlled trials

Background: Hypertensive disorders of pregnancy are the most frequently occurring medical condition during pregnancy, resulting in fetal and/or maternal morbidity and mortality. This meta-analysis compared the efficacy and safety of nifedipine with other antihypertensive medications used in hypertensive disorders of pregnancy. Methodology: A comprehensive search was performed using PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar. The meta-analysis was carried out using Review Manager Software, and the pooled effect estimate was generated as standardized mean difference and odds ratio with 95% confidence interval and two-sided P-value. Results: The meta-analysis was comprised of 22 randomized control trials with 2595 participants. It was found that meantime and number of doses required to achieve target blood pressure were lower in the nifedipine group (P < 0.05). Even though it is statistically insignificant, fetal APGAR (Appearance, Pulse, Grimace, Activity, and Respiration) scores less than seven favors nifedipine intervention. Furthermore, none of the fetal or maternal secondary outcomes were found significant. Conclusion: Nifedipine was found to be more effective than other antihypertensive medications to reduce blood pressure, particularly in patients with severe hypertension. However, future clinical studies, including real-world data are necessary to establish the safety profile of nifedipine concerning the fetal outcomes in hypertensive pregnant women.
Following successful anti-leishmanial treatment, neutrophil counts, CD10 expression and phagocytic capacity remain reduced in visceral leishmaniasis patients co-infected with HIV

Visceral leishmaniasis (VL) patients co-infected with HIV (VL/HIV patients) experience frequent treatment failures, VL relapses, opportunistic infections, and higher mortality. Their immune system remains profoundly suppressed after clinical cure and they maintain higher parasite load. This is in contrast with patients with VL alone (VL patients). Since neutrophils play a critical role in the control of Leishmania replication and the regulation of immune responses, we tested the hypothesis that neutrophil activation status and effector functions are fully restored in VL, but not in VL/HIV patients. Our results show the neutrophil counts and all activation markers and effector functions tested in our study were reduced at the time of diagnosis in VL and VL/HIV patients as compared to controls. CD62L, CD63, arginase 1 expression levels and reactive oxygen species production were restored at the end of treatment in both groups. However, neutrophil counts, CD10 expression and phagocytosis remained significantly lower throughout follow-up in VL/HIV patients; suggesting that dysregulated neutrophils contribute to the impaired host defence against pathogens in VL/HIV patients.
Cosmetic makeup enhances facial attractiveness and affective neural responses

Although it is well established that cosmetic makeup enhances perceived facial attractiveness, few studies have examined whether facial makeup modulates neural responses to face images. This study investigated behavioral and attractiveness-related brain responses to self-applied makeup, focusing on the N170, early posterior negativity, P300, and late positive potential components of event-related brain potentials. A total of 77 Japanese women participated in two experiments (N = 34 and 43 for Experiments 1 and 2, respectively). Experiment 1 assessed the effects of self-applied makeup on attractiveness-related event-related potential amplitudes using facial images during a makeup identification task in which makeup was directly relevant to task demands. Experiment 2 examined the effects of self-applied makeup using images of one’s own face and another female’s face when performing a gender classification task, where the presence of makeup had no explicit connection to facial gender classification. In both experiments, faces with makeup were rated as more attractive and elicited more negative early posterior negativity and more positive late positive potential components, regardless of the participant’s own face or another person’s face. These findings suggest that people are spontaneously motivated to pay visual attention to faces with makeup, which supports the idea that makeup adds reward value to the facial appearance of the human. Moreover, neural evidence empirically confirmed that the benefits of makeup are not just limited to how others see your face but also extend to how you see your own face.
Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy

Autophagy depends on the repopulation of lysosomes to degrade intracellular components and recycle nutrients. How cells co‐ordinate lysosome repopulation during basal autophagy, which occurs constitutively under nutrient‐rich conditions, is unknown. Here, we identify an endosome‐dependent phosphoinositide pathway that links PI3Kα signaling to lysosome repopulation during basal autophagy. We show that PI3Kα‐derived PI(3)P generated by INPP4B on late endosomes was required for basal but not starvation‐induced autophagic degradation. PI(3)P signals were maintained as late endosomes matured into endolysosomes, and served as the substrate for the 5‐kinase, PIKfyve, to generate PI(3,5)P2. The SNX‐BAR protein, SNX2, was recruited to endolysosomes by PI(3,5)P2 and promoted lysosome reformation. Inhibition of INPP4B/PIKfyve‐dependent lysosome reformation reduced autophagic clearance of protein aggregates during proteotoxic stress leading to increased cytotoxicity. Therefore under nutrient‐rich conditions, PI3Kα, INPP4B, and PIKfyve sequentially contribute to basal autophagic degradation and protection from proteotoxic stress via PI(3,5)P2‐dependent lysosome reformation from endolysosomes. These findings reveal that endosome maturation couples PI3Kα signaling to lysosome reformation during basal autophagy.
The Use of Death Certificate Data to Characterize Mortality Associated With Respiratory Syncytial Virus, Unspecified Bronchiolitis, and Influenza in the United States, 1999–2018

Abstract Background Death certificate data can improve our understanding of the mortality burden associated with respiratory syncytial virus (RSV) and influenza. Methods We used International Classification of Diseases, Tenth Revision codes listed on death certificates to characterize deaths from 1999 to 2018 as RSV, influenza, and unspecified bronchiolitis. We described the distribution of each cause of death by age, sex, race/ethnicity, place of death, and contributing causes of death. Results Over the 20-year study period, RSV, bronchiolitis, and influenza were listed as the underlying causes of death on 932, 1046, and 52 293 death certificates, respectively. Children <1 year of age accounted for 39% of RSV and bronchiolitis deaths, while 72% of influenza deaths were in adults ≥65 years. Children <1 year were more likely to die outside of the hospital from RSV, bronchiolitis, or influenza compared to all causes (P < .01), and black infants had the highest mortality rate for all 3 causes. Most infants dying from RSV did not have a high-risk condition listed on the death certificate. Death certificates captured 20%–60% of estimated excess RSV-attributable mortality in infants and <1% in seniors. Conclusions Thorough reporting on death certificates is an important public health goal, especially as new therapeutics become available. Infants had higher odds of dying out of hospital from respiratory pathogens compared to other causes, and race/ethnicity alone did not explain this disparity.
Inequalities in Health Impact of Alternative Reimbursement Pathways for Nirsevimab in the United States

Abstract The target populations and financing mechanisms for a new health technology may affect health inequalities in access and impact. We projected the distributional consequences of introducing nirsevimab for prevention of respiratory syncytial virus in a US birth cohort of infants through alternative reimbursement pathway scenarios. Using the RSV immunization impact model, we estimated that a vaccine-like reimbursement pathway would cover 32% more infants than a pharmaceutical pathway. The vaccine pathway would avert 30% more hospitalizations and 39% more emergency room visits overall, and 44% and 44%, respectively, in publicly insured infants. The vaccine pathway would benefit infants from poorer households.
Bioplatforms in liquid biopsy: advances in the techniques for isolation, characterization and clinical applications

ABSTRACT Tissue biopsy analysis has conventionally been the gold standard for cancer prognosis, diagnosis and prediction of responses/resistances to treatments. The existing biopsy procedures used in clinical practice are, however, invasive, painful and often associated with pitfalls like poor recovery of tumor cells and infeasibility for repetition in single patients. To circumvent these limitations, alternative non-invasive, rapid and economical, yet sturdy, consistent and dependable, biopsy techniques are required. Liquid biopsy is an emerging technology that fulfills these criteria and potentially much more in terms of subject-specific real-time monitoring of cancer progression, determination of tumor heterogeneity and treatment responses, and specific identification of the type and stages of cancers. The present review first briefly revisits the state-of-the-art technique of liquid biopsy and then proceeds to address in detail, the advances in the potential clinical applications of four major biological agencies present in liquid biopsy samples (circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), exosomes and tumor-educated platelets (TEPs)). Finally, the authors conclude with the limitations that need to be addressed in order for liquid biopsy to effectively replace the conventional invasive biopsy methods in the clinical settings.
The overview of neutron-induced 56Mn radioactive microparticle effects in experimental animals and related studies

Abstract Investigation into the risks associated with radiation exposure has been carried out on those exposed to radiation in Hiroshima and Nagasaki, Semipalatinsk and other parts of the world. These risks are used as a guidance standard for the protection for radiation workers and the general public when exposed to radiation, and it sets upper regulatory limits for the amount of radiation exposure. However, the effects of internal exposure to radioactive microparticles have not been considered in these studies. These effects cannot be ignored since the exposure dose increases are inversely proportional to the square of the distance to the vicinity of the particles and can exceed tens of thousands of mGy. So far, only retrospective studies of people who have been exposed to radiation have been conducted, therefore we hypothesized that animal experiments would be necessary to investigate these effects. As a result, we found specific effects of radioactive microparticles. One particularly noteworthy finding was that internal exposure to radioactive microparticles resulted in pathological changes that were more than 20 times greater than those caused by the same level of external exposure. In contrast, there were other results that showed no such effects, and the reasons for this discrepancy need to be clarified. We also conducted RNA expression experiments and found that there was a difference between external exposure to 60Co gamma rays and internal exposure to 56Mn microparticles. In the future, we will need to study the mechanisms behind these findings. If the mechanism can be confirmed, it is expected to lead to the development of protective and therapeutic methods.
Lotilaner Ophthalmic Solution, 0.25%, for the Treatment of Demodex Blepharitis: Results of a Prospective, Randomized, Vehicle-Controlled, Double-Masked, Pivotal Trial (Saturn-1)

Purpose: The purpose of this study was to evaluate the safety and efficacy of lotilaner ophthalmic solution, 0.25%, compared with vehicle for the treatment of Demodex blepharitis. Methods: In this prospective, randomized, controlled, double-masked, phase 2b/3 clinical trial, 421 patients with Demodex blepharitis were randomly assigned in a 1:1 ratio to receive either lotilaner ophthalmic solution, 0.25% (study group), or vehicle without lotilaner (control group) bilaterally, twice daily for 43 days. Patients were evaluated at days 8, 15, 22, and 43. Outcome measures were complete collarette cure (collarette grade 0), clinically meaningful collarette cure (grade 0 or 1), mite eradication (0 mites/lash), erythema cure (grade 0), composite cure (grade 0 for collarettes/erythema), and drop comfort. Adverse events were also evaluated. Results: At day 43, the study group achieved a statistically significantly higher proportion of patients with clinically meaningful collarette cure (81.3% vs. 23.0%; P < 0.0001), complete collarette cure (44.0% vs. 7.4%; P < 0.0001), mite eradication (67.9% vs. 17.6%; P < 0.0001), erythema cure (19.1% vs. 6.9%; P = 0.0001), and composite cure (13.9% vs. 1.0%; P < 0.0001) than the control group. Nearly 92.0% of patients rated the study drop as neutral to very comfortable. All ocular adverse events in the study group were mild, with the most common being instillation site pain. Conclusions: Twice-daily treatment with a novel lotilaner ophthalmic solution, 0.25% for 43 days, is safe and effective for the treatment of Demodex blepharitis compared with the vehicle control.
Salmonella Typhimurium outer membrane protein A (OmpA) renders protection from nitrosative stress of macrophages by maintaining the stability of bacterial outer membrane

Bacterial porins are highly conserved outer membrane proteins used in the selective transport of charged molecules across the membrane. In addition to their significant contributions to the pathogenesis of Gram-negative bacteria, their role(s) in salmonellosis remains elusive. In this study, we investigated the role of outer membrane protein A (OmpA), one of the major outer membrane porins of Salmonella, in the pathogenesis of Salmonella Typhimurium (STM). Our study revealed that OmpA plays an important role in the intracellular virulence of Salmonella. An ompA deficient strain of Salmonella (STM ΔompA) showed compromised proliferation in macrophages. We found that the SPI-2 encoded virulence factors such as sifA and ssaV are downregulated in STM ΔompA. The poor colocalization of STM ΔompA with LAMP-1 showed that disruption of SCV facilitated its release into the cytosol of macrophages, where it was assaulted by reactive nitrogen intermediates (RNI). The enhanced recruitment of nitrotyrosine on the cytosolic population of STM ΔompAΔsifA and ΔompAΔssaV compared to STM ΔsifA and ΔssaV showed an additional role of OmpA in protecting the bacteria from host nitrosative stress. Further, we showed that the generation of greater redox burst could be responsible for enhanced sensitivity of STM ΔompA to the nitrosative stress. The expression of several other outer membrane porins such as ompC, ompD, and ompF was upregulated in STM ΔompA. We found that in the absence of ompA, the enhanced expression of ompF increased the outer membrane porosity of Salmonella and made it susceptible to in vitro and in vivo nitrosative stress. Our study illustrates a novel mechanism for the strategic utilization of OmpA by Salmonella to protect itself from the nitrosative stress of macrophages.
Gravitational waves from Affleck-Dine condensate fragmentation

We compute the stochastic gravitational wave production from Affleck-Dine condensate fragmentation in the early universe, focusing on an effective potential with a logarithmic mass correction that typically arises in gravity mediated supersymmetry breaking scenarios. We find that a significant gravitational wave background can be generated when Q-balls are being formed out of the condensate fragmentation. This gravitational wave background has a distinct multi-peak power spectrum where the trough is closely linked to the supersymmetry breaking scale and whose frequencies are peaked around kHz for TeV supersymmetry breaking.