Miracle-dz/UniFAR-FTUs huggingface dataset:
Physicochemical Evaluation of Edible Cyanobacterium Arthrospira platensis Collected from the South Atlantic Coast of Morocco: A Promising Source of Dietary Supplements

The cyanobacterium Arthrospira platensis (A. platensis)—a genus of nonheterocystous filamentous cyanobacteria—is used in industrial applications and as a food supply. The current research work aims to study the physicochemical characteristics of A. platensis indigenous to the Moroccan Atlantic coast at Laayoune (Foum El Oued lagoon). The contents of proteins, carbohydrates, vitamins, lipids, minerals, heavy metals, energy value, humidity, ash, pigments, and tannins in A. platensis were investigated using protocols as described in the earlier literature. The values of protein, carbohydrate, and lipid contents in A. platensis were 58.9 ± 0.07, 14.67, and 45.54% respectively. The values of vitamins B2 and B3 dosed in A. platensis were 1.31 ± 0.19 and 30.8 ± 0.001 mg/kg, respectively. The values of heavy metals including lead and chromium were 70 ± 4.5 and 5 ± 0.5 PPB (parts-per-billion), respectively; however, no trace concerning cadmium was detected. The values of energy value, humidity, and ash content were 346.48 ± 0.21, 11.6 ± 0.17%, and 9.1 ± 0.21% kcal/100 g, respectively. The results of pigment content showed the presence of chlorophyll b, chlorophyll a, and carotenoids of 37.506 ± 3.38, 26.066 ± 3.08, and 9.52 ± 0.22 mg/g, respectively. The results obtained revealed that A. platensis indigenous to the Moroccan Atlantic coast at Laayoune was found to be very rich in proteins, carbohydrates, vitamins, minerals, ash, and pigments and lower in heavy metals and saturated fats when compared with species investigated in the literature. Thus, A. platensis indigenous to the Moroccan Atlantic coast at Laayoune fulfills the requirements for being used as dietary supplements.
A Review of Caffeine Adsorption Studies onto Various Types of Adsorbents

A systematic literature review of publications from 2000 to 2020 was carried out to identify research trends on adsorbent materials for the removal of caffeine from aqueous solutions. Publications were retrieved from three databases (Scopus, Web of Science, and Google Scholar). Words “adsorption AND caffeine” were examined into titles, abstracts, and keywords. A brief bibliometric analysis was performed with emphasis on the type of publication and of most cited articles. Materials for the removal of caffeine were classified according to the type of material into three main groups: organic, inorganic, and composites, each of them subdivided into different subgroups consistent with their origin or production. Tables resume for each subgroup of adsorbents the key information: specific surface area, dose, pH, maximum adsorption capacity, and isotherm models for the removal of caffeine. The highest adsorption capacities were achieved by organic adsorbents, specifically those with granular activated carbon (1961.3 mg/g) and grape stalk activated carbon (916.7 mg/g). Phenyl-phosphate-based porous organic polymer (301 mg/g), natural sandy loam sediment (221.2 mg/g), composites of MCM-48 encapsulated graphene oxide (153.8 mg/g), and organically modified clay (143.7 mg/g) showed adsorption capacities lower than those of activated carbons. In some activated carbons, a relation between the specific surface area (SSA) and the maximum adsorption capacity (Qmax) was found.
Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma

Objective To investigate the antitumor effect of andrographolide on the ATC cell lines 8505C and CAL62 and to explore the possible mechanism of the effect. Methods CCK8 and colony formation assays were performed to detect proliferation. Cell migration was tested by scratch assay. Annexin V/PI staining was used to detect cell apoptosis and cell cycle. Glucose and lactic acid kits were carried out to evaluate the glycolysis level after andrographolide treatment. Western blot was used to detect the changes in the apoptosis-related proteins and glycolysis-related enzymes in both 8505C and CAL62 cells. Results Treatment with 60 μM andrographolide had significant effects on 8505C and CAL62, including inhibition of proliferation, inhibition of migration, arrest of the cell cycle, promotion of apoptosis, and inhibition of glycolysis. Conclusion Andrographolide has an antitumor effect and can significantly affect glycolysis in ATC cells.
High-pressure experiments on phase transition boundaries between corundum, Rh2O3(II)- and CaIrO3-type structures in Al2O3

Abstract Phase transitions in Al2O3 between corundum Rh2O3(II)-type and CaIrO3-type (post-perovskitetype) phases were examined at high pressure and high temperature in a laser-heated diamond-anvil cell (DAC) based on in situ X-ray diffraction measurements. The locations of corundum-Rh2O3(II) and Rh2O3(II)-CaIrO3 boundaries were precisely determined by conducting both forward and backward reaction experiments. The results demonstrate that corundum undergoes a phase transition to Rh2O3(II)-type structure above 106 GPa at 1800 K with a negative Clapeyron slope of -6.5 ± 1.5 MPa/K, generally consistent with earlier experimental and theoretical works. The Rh2O3(II)-type phase further transforms into CaIrO3-type above 170 GPa at 2300 K, indicating the transition pressure much higher than earlier experimental work but in agreement with reported GGA calculations. The Clapeyron slope of this phase transition was found to be high negative (-20 ± 5 MPa/K).
A Hybrid Algorithm with Modified SVM and KNN for Classification of Mammogram Images using Medical Image Processing with Data Mining Techniques

: Digital mammography is most reliable and effective technique for early and accurate identification of Breast cancer. Image processing plays a significant role in diagnosis and classification of breast cancer in medical field. In this paper, a system is created to classify the mammogram images into three classes, namely Benign, Malignant and Normal. Mammogram images are pre-processed and the features are extracted from the segmented region. These features are used to train modified SVM and KNN classifier. The proposed Hybrid algorithm with modified SVM and KNN classifier helps to classify the mammogram images. This latest technique improves the SVM algorithm with introducing multi class for classification of breast cancer. It exploits the KNN algorithm according to the distribution of test images in a feature space. This study also evaluates the accuracy with the SVM and KNN classifier. The modified SVM and KNN hybrid algorithm produces higher prognosis accuracy than the KNN method and SVM technique. This method is tested for 10 test images with 20 trained. This methodology achieves an overall mean accuracy of 99.3406% in classification of mammogram images.
A Reward Shaping Approach for Reserve Price Optimization using Deep Reinforcement Learning

Real Time Bidding is the process of selling and buying online advertisements in real time auctions. Real time auctions are performed in header bidding partners or ad exchanges to sell publishers' ad placements. Ad exchanges run second price auctions and a reserve price should be set for each ad placement or impression. This reserve price is normally determined by the bids of header bidding partners. However, ad exchange may outbid higher reserve prices and optimizing this value largely affects the revenue. In this paper, we propose a deep reinforcement learning approach for adjusting the reserve price of individual impressions using contextual information. Normally, ad exchanges do not return any information about the auction except the sold-unsold status. This binary feedback is not suitable for maximizing the revenue because it contains no explicit information about the revenue. In order to enrich the reward function, we develop a novel reward shaping approach to provide informative reward signal for the reinforcement learning agent. Based on this approach, different intervals of reserve price get different weights and the reward value of each interval is learned through a search procedure. Using a simulator, we test our method on a set of impressions. Results show superior performance of our proposed method in terms of revenue compared with the baselines.
A Mixed-Reality Approach for Cyber-situation Awareness

Title: A Mixed-Reality Approach for Cyber-situation Awareness Author: Tapas Dipakkumar Joshi Committee Chair: Marco Carvalho, Ph.D. As the proliferation and adoption of smart devices increase, there is an unprecedented amount of data being released into the network every second. Computer networks are the carriers for the movement of this ever generating amounts of data, but are dumb in a way that they do not distinguish between suspicious data traffic and valid data traffic. Also, for however secure a computer network be, suspicious network traffic activities are bound to happen. These suspicious traffic activities have to be detected, analyzed and stopped before it compromises the entire network and leaves the information and data security of an organization in mayhem. There are several tools and visualizations for cybersecurity awareness at the disposal of security analysts and network operators. These helpful tools often lack in having the property of being intuitive and cognitive. Using the amalgamation of Mixed Reality, localization and mapping techniques, this thesis researches and implements a way of augmenting network traffic information right on the top of every computer system. The availability of network data rightly where it needs to be tagged and right when it is needed will help security analysts to better understand network activities and also locate the infected system and take quick actions if need be. In this thesis, we design and build a prototype that demonstrates how Mixed Reality provides better situation awareness to cyber operators managing a physical space.
Effective Cytotoxicity of Dendritic Cells against Established T Cell Lymphomas in Mice

T cell lymphomas arise in mice that constitutively express a single TCR in the absence of NK cells. Upon TCR engagement these lymphomas are able to corrupt tumor surveillance by decreasing NK cell numbers. In this study, we investigate the outcome of interactions between these T cell lymphomas and dendritic cells. Bone marrow–derived dendritic cells mediated effective killing of T cell lymphomas after activation with IFN-γ and TLR ligands in culture. This cytotoxicity was independent of MHC compatibility. Cell lysis was reduced by the presence of the peroxynitrite inhibitors FeTTPS and L-NMMA, whereas inhibitors of apoptosis, death receptors, and degranulation were without effect, suggesting NO metabolites as the main mediators. When injected together with GM-CSF and R848 into lymphoma-bearing mice, in vitro–expanded bone marrow–derived dendritic cells caused significant survival increases. These data show that dendritic cell adaptive immunotherapy can be used as treatment against T cell lymphomas in mice. Key Points Stimulated bone marrow–derived dendritic cells lyse T lymphoma target cells in vitro. Dendritic cell–mediated cytotoxicity is dependent on peroxynitrite. Dendritic cell transfers into T lymphoma-bearing mice show antitumor efficacy.
Different circulating biomarkers in women and men with paroxysmal atrial fibrillation: results from the AF-RISK and RACE V studies

Abstract Aims The clinical risk profile of atrial fibrillation (AF) patients is different in men and women. Our aim was to identify sex differences in blood biomarkers in patients with paroxysmal AF. Methods and results Sex differences in 92 blood biomarkers were measured in 364 patients included in our discovery cohort, the identification of a risk profile to guide atrial fibrillation therapy (AF-RISK) study, assessed by multivariable logistic regression and enrichment pathway analysis. Findings were subsequently confirmed in 213 patients included in our validation cohort, the Reappraisal of Atrial Fibrillation: Interaction between HyperCoagulability, Electrical remodelling, and Vascular Destabilisation in the Progression of AF (RACE V) study. In the discovery cohort, mean age was 59 ± 12 years, 41% were women. CHA2DS2-VASc-score was 1.6 ± 1.4. A total of 46% had hypertension, 10% diabetes, and 50% had heart failure, predominantly with preserved ejection fraction (47%). In women, activated leucocyte cell adhesion molecule (ALCAM) and fatty acid binding protein-4 (FABP-4) were higher. In men, matrix metalloproteinase-3 (MMP-3), C-C motif chemokine-16 (CCL-16), and myoglobin were higher. In the validation cohort, four out of five biomarkers could be confirmed: levels of ALCAM (P = 1.73 × 10–4) and FABP-4 (P = 2.46 × 10–7) and adhesion biological pathways [false discovery rate (FDR) = 1.23 × 10–8] were higher in women. In men, levels of MMP-3 (P = 4.31 × 10–8) and myoglobin (P = 2.10 × 10–4) and markers for extracellular matrix degradation biological pathways (FDR = 3.59 × 10–9) were higher. Conclusion In women with paroxysmal AF, inflammatory biomarkers were more often higher, while in men with paroxysmal AF, biomarkers for vascular remodelling were higher. Our data support the clinical notion that pathophysiological mechanisms in women and men with AF may differ. Trial registration Clinicaltrials.gov identifier NCT01510210 for AF-RISK; Clinicaltrials.gov NCT02726698 for RACE V.
Strengths and Difficulties in Children with Specific Learning Disabilities.

BACKGROUND The study aims to investigate the social, emotional, and behavioral challenges in children with a specific learning disability (SLD) and to identify the factors that accompany these problems by screening with the Strengths and Difficulties Questionnaire (SDQ). METHODS The descriptive study was conducted on 278 children with SLD. Strengths and difficulties in children were evaluated by the SDQ applied to their mothers. The percentage of cases above the cut-off limits of the SDQ was calculated. Chi-square test and multiple logistic regression analysis were used for analysis. RESULTS The mean (SD) total SDQ score was 15.8 (6.5). The percentage of scores of abnormal total difficulties in SLD was 47.8%. Multivariate analysis revealed that cases exposed to antenatal smoking had higher odds ratio of abnormal emotional symptoms and abnormal total difficulties; cases with poor familial income and the presence of a history of antenatal smoking exposure showed considerably higher odds ratio of conduct problems; cases with younger age at the diagnosis of SLD, dyscalculia, extreme duration of preschool screen time (≥4 hrs), and history of hospitalization had significantly higher higher odds ratio for hyperactivity-inattention problems; and cases having shorter breastfeeding duration had higher odds ratio of peer problems compared to counterparts. CONCLUSION Children with SLD have a high score on the SDQ. Practitioners could especially give guidance and support to families with financial problems and those having a child with an early age at diagnosis, exposure to antenatal smoking, short breastfeeding period, early age of the first screen use, and long screen exposure duration during the preschool period.
The effects of amending soil with stored manure from cattle supplemented with 3- nitrooxypropanol on select soil health indicators and hydraulic properties.

Supplementing beef cattle with 3-nitrooxypropanol (3-NOP) decreases enteric methane production, but it is unknown if fertilizing soil with 3-NOP manure influences soil health. We measured soil health indicators two years after manure application to a bromegrass (Bromus L.) and alfalfa (Medicago sativa, L.) mixed-crop. Treatments were: composted conventional manure (without supplements); stockpiled conventional manure; composted manure from cattle supplemented with 3-NOP; stockpiled 3-NOP manure; composted manure from cattle supplemented with 3-NOP and monensin (3-NOP+Mon), a supplement that improves digestion; stockpiled 3-NOP+Mon manure; inorganic fertilizer (150 kg N ha-1 and 50 kg P ha-1 ); and an unamended control. Select chemical (K+ , Mg2+ , Mn+ , Zn+ , pH, and Olsen-P), biological (soil organic matter, active C, respiration, and extractable protein), physical (wet aggregate stability, bulk density, total porosity, and macro-, meso-, and micro-porosity), and hydraulic (saturation, field capacity, wilting point, water holding capacity, and hydraulic conductivity) variables were measured. The inclusion of monensin decreased soil Zn+ concentrations by 70% in stockpiled 3-NOP+Mon compared to stockpiled conventional manure. Active C and protein in composted conventional manure were 37 and 92% higher compared to stockpiled manure, respectively, but did not vary between 3-NOP treatments. 3- Nitrooxypropanol did not significantly alter other soil health indicators. Our results suggest that composted and stockpiled 3-NOP manure can be used as a nutrient source for forage crops without requiring changes to current manure management because it has minimal influence on soil health. This article is protected by copyright. All rights reserved.
Retrospective Cross-sectional Analysis of Factors Associated with Asthma in a Pediatric Cohort from Turkey

Abstract Background It is difficult to identify young children at increased risk of developing asthma amongst those with recurrent wheezing. In this study, we aimed to determine factors associated with asthma in Turkish children. Methods We performed a retrospective cross-sectional analysis on factors associated with asthma in 651 children (200 girls, 451 boys) admitted for recurrent wheezing. Results Amongst all included children, asthma frequency was 57.7%. Maturity, consanguinity, family income, passive smoking, father’s, siblings’ asthma were not found to be associated with asthma. Factors associated with asthma were: family’s, parents’, siblings’ atopy, family’s, mother’s asthma, allergic rhinitis and atopic dermatitis, respiratory symptoms between wheezing attacks. The sensitivity (SN) of the modified asthma predictive index (mAPI) was 59.2% with a specificity (SP) of 91.3%, positive predictive index (PPI) of 65.1% and negative predictive index (NPI) of 82.3%. The SN of the modified Prevention and Incidence of Asthma and Mite Allergy (PIAMA) score was 22.9% with a SP of 89.2%, PPI of 84.6%, and NPI of 42.2%. Adjusted odds ratio for mAPI was 12.9, and for the modified PIAMA score 4. Conclusion Our analysis confirmed previously described factors associated with asthma. Although the SN is limited, the mAPI and PIAMA risk scores can be used to predict asthma in Turkish children. Differential diagnoses and overlaps with other chronic pediatric diseases such as immunodeficiencies need to be carefully excluded when confirming the diagnosis asthma.
RELATIONSHIP BETWEEN PHYSICAL ACTIVITY PARTICIPATION AND RECOVERY OUTCOMES IN COLLEGE-AGED ADULTS WITH A CONCUSSION.

CONTEXT Previously, the most common treatment for a concussion was prolonged physical and cognitive rest. Recent research suggests that earlier physical activity (PA) may be better at promoting recovery. Research has not evaluated the relationship between free-living PA (e.g., walking) and symptom reporting or recovery duration. OBJECTIVE To assess the relationship between free-living physical activity (PA) participation and two recovery outcomes in college-aged adults with a concussion. DESIGN Prospective Cohort Setting: Division 1 & 3 Universities Participants: Thirty-two college-aged adults (68.8% female, age: 19.8±1.4) with a concussion. MAIN OUTCOME MEASURES Participants completed a post-concussion symptom evaluation at visits 1 (<72 hours from concussion) and 2 (8 days later). Between visits, participants' PA was monitored using an Actigraph GT9X Link PA monitor and expressed as total PA (counts per minute) and percent time of PA spent in moderate-to-vigorous intensity (%MVPA). Recovery time was the number of days from injury occurrence to medical clearance. Separate hierarchical multiple regressions evaluated the relationship between total PA and each recovery variable (visit 2 symptom severity, recovery time). Additionally, separate exploratory hierarchical multiple regressions evaluated the relationship between %MVPA and each recovery variable. Statistical significance was set a priori at p ≤ . 05. RESULTS Participants averaged 2446±441 counts per minute and spent 12.1±4.2% of their PA performing MVPA. Participants yielded median symptom severities of 28[24] and 2[8] for visit 1 and 2, respectively. Average recovery time was 14.7±7.5 days. Total PA did not significantly contribute to the model for visit 2 symptom severity (p=.122) or recovery time (p=.301). Similarly, %MVPA had little contribution to the model for visit 2 symptom severity (p=.358) or recovery time (p=.276). CONCLUSION Results suggest that free-living PA may not be enough to reduce symptoms or shorten recovery. Thus, clinicians may need to provide patients with more structured PA protocols mimicking previous research.
Modulation of Angiogenesis by Inflammatory Markers and the Role of Matrix Metalloproteinases in an Endothelial Cell/Fibroblast Co-culture System

: Increased levels of inflammatory markers such as tumour necrosis factor- α (TNFα) and inter - leukin-6 (IL - 6) have been associated with formation of new blood vessels, or angiogenesis, and linked to chronic inflammation in obesity. This study aimed to establ ish and use a versatile co-culture cell system to further investigate the role of TNFα and IL - 6 in modulating (i) tubule formation and (ii) cell -cell interactions via matrix metalloproteinase (MMP) enzyme activity and secretion of vascular endothelial growth factor (VEGF), E-selectin and prostaglandin E 2 (PGE 2 ). Co - cultures of human endothelial cells and fibroblasts were incubated with TNFα (10 ng/mL) or IL - 6 (10 ng/mL) added 2 and/or 7 days after co - culture establishment. Cell viability by enzymatic conve rsion was determined by MTT assay; tubule formation was detected by immunostaining; VEGF, E -selectin and PGE 2 expression by ELISA analysis and MMP enzyme activity by gel zymography. Treatment - specific and time dependent differences in tubule formation were observed: IL - 6 significantly increased tubule formation, whilst TNFα significantly inhibited tubule formation. Treatment - specific differences in levels of MMP activities which correlate to tubule formation were also observed. This study showed inflammato ry markers, typically associated with obese status, affect tubule formation differently in a heterogeneous cell environment similar to that observed in vivo . of the of into condi tioned was investigated using Results that co- culture treatment with TNFα induced an in- crease in secretion or accumulation of VEGF in the medium compared to co - cultures grown in EGM - 2Ө and the increase in concentration paralleled the lack of tubules formed. These observations support previous studies which emphasise the key role and requirement of VEGF in new tubule formation [27]. 2