Miracle-dz/UniFAR-FTUs huggingface dataset:
System Architecture of Big Data in Massive Open Online Courses (BD-MOOCs System Architecture)

The system architecture of big data in massive open online courses (BD-MOOCs System Architecture) is composed of six components. The first component was comprised of big data tools and technologies such as Hadoop, YARN, HDFS, Spark, Hive, Sqoop, and Flume. The second component was educational data science, which is composed of the following four parts: EDM, ERS, AA, and S/II. The third component was a description of three basic elements of a big data system: data capture, management, and analysis. The fourth component was that MOOCs were classified as cMOOCs, xMOOCs, quasi-MOOCs, hMOOCs, and other related. The fifth component included the steps of MOOC development: design, delivery, and assessment. Finally, MOOCs present educational data science challenges such as analyzing student interactions, estimating dropout risk, grading, and making recommendations. Overall, the BD-MOOCs system architecture design was suitable at the highest level.
Monitoring the shape parameter of a Weibull renewal process

ABSTRACT This research arose from a challenge faced in real practice—monitoring changes to the Weibull shape parameter. From first-hand experience, we understand that a mechanism for such a purpose is very useful. This article is primarily focused on monitoring the shape parameter of a Weibull renewal process. We derive a novel statistic on the Weibull shape parameter making use of maximum likelihood theory, which is demonstrated to follow an approximately normal distribution. This desirable normality property makes the statistic well suited for use in monitoring the Weibull shape parameter. It also allows for a simple approach to constructing a Shewhart-type control chart, named the Beta chart. The parameter values required to design a Beta chart are provided. A self-starting procedure is also proposed for setting up the Phase I Beta chart. The Average Run Length (ARL) performance of the Beta chart is evaluated through Monte Carlo simulation. A comparison with a moving range exponentially weighted moving average (EWMA) chart from the literature shows that the Beta chart has much better ARL performance when properly designed. Application examples, using both simulated and real data, demonstrate that the Beta chart is effective and makes good sense in real practice.
Multiphysics Design Optimization of Microwave Ablation Antennas

Multiphysics Design Optimization of Microwave Ablation Antennas Shashwat Sharma Master of Applied Science Graduate Department of Electrical and Computer Engineering University of Toronto 2016 Microwave ablation is based on localized heating of biological tissues, enabled by an electromagnetic field. Antennas for ablation are commonly designed in a forward approach to generate a particular Specific Absorption Rate profile within the target. However, little attention has been dedicated to designing antennas inversely, to allow controllable synthesis of temperature profiles customized for the application. Also, most existing designs do not account for thermal inhomogeneities in tissue. An inverse, multiphysics methodology for microwave ablation antenna design is presented herein, that involves optimizing the antenna’s current distribution to synthesize a desired temperature profile, while accounting for heat diffusion. The results indicate and quantify the clear advantages of this multiphysics approach. This methodology is successfully applied towards designing an easily configurable printed dipole microwave ablation antenna that addresses several limitations of existing designs. This design provides the functionality of a phased array, and allows controlled synthesis of temperature profiles.
Weavers’ Aesthetic Perception on the Visual Complexity of Pua Kumbu Design Motifs: An Exploratory Study

Visual complexity can offer a unique direction on how perceivers react and shape their aesthetic perceptions, relying on the art’s formalistic elements and visual content. This study aims to evaluate the weavers’ aesthetic perception of the complexity of the Pua Kumbu design motifs. The complicated art piece was highlighted as the Iban identity, which resembles the Iban’s way of life, beliefs, taboos, and surroundings hidden in the textile patterns. The weaver’s interpretation is its success in transferring the knowledge to the perceivers as they are the storyteller of this majestic art piece. The complexity of the symbols presented in the design motifs contributes to the lack of interest, especially among the young generation, in understanding these motifs' meaning. Thus, a qualitative approach was used to explore the weavers’ perception of the design motifs’ complexity using interviews in structured and unstructured questions. The findings contributed to a basic understanding and the sustainability of traditional human values, hoping that the textile as a valuable heritage will survive and remain relevant for the long term.
Positively Charged Gold Quantum Dots: An Nanozymatic “Off-On” Sensor for Thiocyanate Detection

The concentration of thiocyanate (SCN−) in bodily fluids is a good indicator of potential and severe health issues such as nasal bleeding, goiters, vertigo, unconsciousness, several inflammatory diseases, and cystic fibrosis. Herein, a visual SCN− sensing method has been developed using the enzyme-like nature of positively charged gold quantum dots (Au QDs) mixed with 3,3′,5,5′-tetramethylbenzidine (TMB) and hydrogen peroxide (H2O2). This research also reports a new method of synthesizing positively charged Au QDs directly from gold nanoparticles through a hydrothermal process. Microscopic imaging has showed that the Au QDs were 3–5 nm in size, and the emission wavelength was at 438 nm. Au QDs did not display any enzyme-like nature while mixed up with TMB and H2O2. However, the nanozymatic activity of Au QDs appeared when SCN− was included, leading to a very low detection limit (LOD) of 8 nM and 99–105% recovery in complex media. The steady-state kinetic reaction of Au QDs showed that Au QDs had a lower Michaelis–Menten constant (Km) toward H2O2 and TMB, which indicates that the Au QDs had a higher affinity for H2O2 and TMB than horseradish peroxidase (HRP). A mechanism study has revealed that the scavenging ability of hydroxyl (•OH) radicals by the SCN− group plays an important role in enhancing the sensitivity in this study. The proposed nanozymatic “Off–On” SCN− sensor was also successfully validated in commercial milk samples.
Prepoznavanje idiomatskih besednih zvez z uporabo besednih vložitev

Prisotnost idiomov v besedilu povzroča probleme številnim pristopom na področju obdelave naravnega jezika, saj jih računalniki težko prepoznajo. Strojno prepoznavanje takšnih izrazov še ni rešen problem. V zadnjih letih so se razvile številne metode, ki lahko prepoznajo različne pomene besed glede na njihovo okolico in na podlagi tega zgradijo kontekstne vektorske vložitve besed. Takšne vložitve bi morale biti primerne za zaznavanje idiomov. Trenutni pristopi ali ne uporabljajo vektorskih vložitev, ali pa uporabljajo ne-kontekstne vložitve. V delu pokažemo, kako lahko uporabimo kontekstne vložitve besed za ločevanje med dobesedno in idiomatsko rabo besed. Pokažemo, da lahko z različnimi značilkami (npr., s kontekstualnimi vektorji in razdaljami do srednjih kontekstualnih vektorjev za vsako besedo) zaznamo idiome prisotne v korpusu anglešikh besedil GloWbE.
Design of efficient rectifier using IDC and harmonic rejection filter in GSM/CDMA band for RF energy harvesting

An improved rectifier based on harmonic rejection filter with inter‐digital capacitor for RF energy harvesting application is proposed. The designed circuit is fabricated on a low cost FR‐4 substrate, and works at GSM/CDMA 900 MHz band. The measured maximum efficiency is 66.31% and maximum obtained power is 15.13 mW at 1.1 KΩ load value. The overall dimension of circuit is 80 × 45 × 1.6 mm3, which can be easily implemented in any device for energizing wireless sensor network. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:681–686, 2017
Evaluation of different household practices to decontaminate organophosphate insecticide residues from Amaranthus tricolor L.

Amaranthus tricolor L (Amaranth) is a major leafy vegetable extensively cultivated in Kerala. Efficiency of different decontaminating methods viz., washing, cooking, 2% common salt, 2% vinegar, 1% turmeric, 2% tamarind and 1% veggie wash (produced by Kerala Agricultural University, Vellayani), in the removal of organophosphate insecticide residues from amaranth, sprayed with different organo phosphate insecticides viz., chlorpyriphos 20% EC, dimethoate 30 EC, ethion 50% EC, malathion 50 % EC, profenofos 50% EC and quinalphos 25% EC, indicated that dipping in 1% veggie wash for 20 minutes followed by three further washings plus cooking was found to be most effective in removal of OP insecticide residues (83%), followed by 1 % veggie wash for 20 minutes, 1% veggie wash for 10 minutes plus cooking and 2% vinegar (78, 76 and 74% respectively).
The effects of improved conductivity on actuation

In this study, we investigate the effect of enhancing electrical and ionic conductivity of PEDOT:PSS/PVDF/PEDOT:PSS tri-layer actuators on the speed of charging and of mechanical actuation. We treated the conducting polymer films with methanol, then doped the device with ionic liquid electrolyte. For both treated and untreated tri-layer samples, we measured electrical resistance along the length of the film, ionic resistance through the thickness of the structure, and performed cyclic voltammetry to determine volumetric capacitance and the characteristic time constants. We also measured the mechanical displacement-frequency response of the conducting polymer cantilever beams. Our results showed that methanol treatment increased electrical conductivity by 20x and ionic conductivity by 1.7x. This enhancement did not significantly change the cut-off frequencies of the device. However, at frequencies < 1 Hz, we observed less drop-off in displacement amplitude in the treated samples. For the geometries and conductivities used in this study, improving conductivity of PEDOT:PSS contributed to actuation at frequencies above the cut-off frequency. This may have applications for devices that need to actuate at high frequencies, but not necessarily at maximum strain, such as vibrotactile haptic displays.
Features of hapten specific sensitization and immune status in different student age groups

In recent decades, the frequency and prevalence of allergic diseases among children have increased dramatically. The aim of the current study was to investigate features of hapten specific sensitization and immune status in different student age groups during high-intensity educational process. A number of parameters related to specific sensitization to metals and organic compounds were studied: 67 first grade children and 35 6-7 grade children attending school with a high-intensity educational process simultaneously chronically exposed to exogenous chemical haptens (the observation group No. 1 and observation group No. 2, respectively); in 20 primary school students and 27 6-7 grade students educated in the absence of excessive exposure to negative factors (the comparison group No. 1 and comparison group No. 2, respectively). Measurement of serum IgE immunoglobulins specific to manganese, IgE specific to nickel, formaldehyde as well as IgG specific to benzene, lead, phenol was carried out by using enzymeallergosorbent test; level IL-4 (Th2) was assessed by enzyme-linked immunosorbent assay; level of CD19+ receptor expression on lymphocytes was estimated by flow cytometry. A simple linear regression analysis was used to analyze the data. To test null hypotheses about equality of mean values between two independent groups with a normal distribution, a two-sample Student’s t-test was used. It was found out that the degree of specific sensitization changed with age in students chronically exposed to exogenous haptens. The level of specific sensitization to organic compounds increases markedly in high school students vs. to primary school children (IgG level to phenol elevated by 1.5 times) paralleled with profoundly increased production of Th2 cytokines (IL-4 – by 1.8-fold) as well as activated humoral immunity (percentage of CD19+ lymphocytes increased by 1.3-fold). Probable causative link was found between amount of serum exogenous phenol hapten and increased concentration of phenol-specific IgG (F = 140.81; R2 = 0.53; p 0.001). Hapten-specific sensitization in school students increases progressively with age or duration of hapten exposure.
Learning Behavior Analysis and Learning Effect Evaluation in Open Online Courses

In the context of globalization, the trend of globalization in the field of education is becoming more and more significant. With the maturity of Internet and cloud computing, a large online open course learning platform providing courses and educational services for global users has emerged in the past few years. This is not only the innovation of Internet applications, but it is also believed that it will trigger a change in higher education and social development. The main body of online open courses is learners, and its biggest feature is that there are a large number of learners and a variety of learner groups. Due to the characteristics of Internet technology, all learning behaviors of learners on the online open course platform will be recorded in the form of rich and diverse data. Therefore, it is necessary to analyze learners’ learning behavior. This paper proposes a dual-channel clustering algorithm, which analyzes and mines a large number of learning behavior data of more than 5000 learners in online open courses of a university. This method takes fine-grained data as the core, obtains the types of learners in different models through dual-channel clustering calculation, and finally characterizes learners based on the fused model. Compared with three state-of-the-art clustering algorithms, the experimental results show that the proposed dual-channel clustering algorithm can enhance the cohesion of clusters, cluster learners more accurately, and characterize learners’ profiles more deeply and com-prehensively.
Enhanced photodynamic therapy of TiO2/N-succinyl-chitosan composite for killing cancer cells

composite (TiO 2 / NSCS) photodynamic therapy (PDT), while considering the effects of various light sources on the activation of photosensitizer. The methyl thiazolyl tetrazolium assay was used to examine the cell survival rate of the cells. The results showed that glioma cell strain (U251) was the most sensitive cancer cell strain to TiO 2 /NSCS. When the concentration of TiO 2 /NSCS was between 0 and 800 μg·mL -1 , there was no obvious cytotoxicity to normal liver cells (HL-7702) and U251 cells. During the PDT process, the photokilling effect of TiO 2 /NSCS on U251 cells under ultraviolet-A (UVA) light irradiation was stronger than that of pure TiO 2 , and its killing effects were positively correlated with concentration and irradiation time. In addition, both UVA and visible light could excite TiO 2 / NSCS, which had significant killing effect on U251 cells. The results of acridine orange/ethidium bromide fluorescent double staining and Annexin V/propidium iodide double staining indicated that TiO 2 /NSCS under UVA and visible light irradiation could kill U251 cells by inducing apoptosis, and the apoptosis rate of TiO 2 /NSCS treatment groups was higher than that of TiO 2 treatment groups. Therefore, TiO 2 /NSCS might be used as a potential photosensitizer in PDT.
Treatment of dyes contaminated water using surfactants modified activated carbon derived from rice husk

In the present work, the surfactant modified activated carbon (AC) was used for the elimination of water soluble dyes, i.e. methylene blue (MB) and crystal violet (CV) dyes from aqueous solutions. The AC was prepared from rice husk by carbonization process, and then activated by treat- ment with zinc chloride (ZnCl 2 ). The AC was further modified by sodium dodecyl sulfate (SDS) and sodium cupryl acetate (SCA) surfactants. The AC, SDS/AC and spent SDS/AC were characterized by SEM, FT-IR, XRD and EDX analysis. Under optimized conditions the adsorption was found to be better as compared to be AC and SCA/AC, under which maximum adsorption of MB and CV over SDS/AC was found to be 90% and 85%, respectively. Kinetic and isotherm studies revealed that adsorption of both dyes over SDS/AC occur through pseudo-second-order kinetics and follow the Freundlich adsorption isotherm model. The various thermodynamic parameters, like Δ G °, Δ H ° and Δ S ° shown that the process of adsorption dyes over SDS/AC was an endothermic and spontaneous process. According to the data analysis that % removal of MB using AC, SCA/AC and SDS/ AC was 75%, 83% and 84.86%, separately, while using same adsorbents the % removal of CV was 31.5%, 79% and 84.94%, respectively. It is clear from these consequences that the adsorption effec- tiveness of the AC was significantly enhanced with the surfactant modification. Findings from this study suggest that SDS/AC could be utilized as a promising adsorbent at the same time eliminating MB and CV from wastewater.
Unprecedented strong and reversible atomic orbital hybridization enables a highly stable Li–S battery

Abstract The shuttle effect and excessive volume change of the sulfur cathode severely impede the industrial implementation of Li–S batteries. It is still highly challenging to find an efficient way to suppress the shuttle effect and volume expansion. Here, we report, for the first time, an innovative atomic orbital hybridization concept to construct the hierarchical hollow sandwiched sulfur nanospheres with double-polyaniline layers as the cathode material for large-scale high-performance Li–S batteries. This hierarchically 3D, cross-linked and stable sulfur–polyaniline backbone with interconnected disulfide bonds provides a new type and strong intrinsic chemical confinement of sulfur owing to the atomic orbital hybridization of Li 2s, S 3p, C 2p and N 2p. Crucially, such atomic orbital hybridization of sulfur sandwiched in the double sulfur–polyaniline network is highly reversible during the discharge/charge process and can very efficiently suppress the shuttle effect and volume expansion, contributing to a very high capacity of 1142 mAh g–1 and an excellent stabilized capacity of 886 mAh g–1 at 0.2 C after 500 cycles with a suppressed volume expansion and an unprecedented electrode integrity. This innovative atomic orbital hybridization concept can be extended to the preparation of other electrode materials to eliminate the shuttle effect and volume expansion in battery technologies. The present work also provides a commercially viable and up-scalable cathode material based on this strong and highly reversible atomic orbital hybridation for large-scale high-performance Li–S batteries.
Relevance of E × B drifts for particle and heat transport in divertors

Radial electric fields up to ∼4 kV m−1 are observed in the boundary between the private flux region (PFR) and the scrape-off layer (SOL) driving E × B drifts between the inner and outer targets at speeds up to 2.8 km s−1 in the Tokamak à configuration variable divertor. The resulting E × B fluxes, located in a narrow region ( ΔρΨ<0.012 in normalized radius or Δ R − R sep <4 mm mapped to the outer midplane) are equivalent to around 20% of the total heat and particle flux to the divertor targets (inner + outer). At the peak E r, the E × B poloidal transport is equivalent to parallel flows with M ∥ ∼ 3. In the snowflake divertor with a second X-point in the outer SOL, the drifts in the PFR-SOL boundary were equivalent to around 30% of the total heat and particle flux to the divertor targets and cover a region ∼50% wider than in the single null ( ΔρΨ ∼ 0.018, Δ R − R sep ∼ 6 mm). The location of the PFR-SOL boundary drift shifts radially in the E ∥ × B direction when reversing the toroidal field direction. Peaks in density and electron pressure have been identified near the primary X-point along with large gradients in density, temperature, and potential, the latter resulting in a local electric field ∼2.7 kV m−1 which drives a drift (1.9 km s−1) upwards towards the closed flux surfaces. Floating potential (V f) magnitudes up to 75 V (∼2 kTe) were measured, indicating that V f and parallel currents should not be neglected when estimating plasma potential.
Atendimento à demanda espontânea na Estratégia Saúde da Família: práticas e reflexões de um processo em construção

Resumo A Estratégia Saúde da Família como estratégia de reorientação da Atenção Primária à Saúde é recente no histórico do Sistema Único de Saúde, demandando muitos desafios. O presente estudo tem como objetivo compreender a percepção do médico no contexto da saúde da família em relação ao atendimento à demanda espontânea. Trata-se de uma pesquisa exploratória com abordagem qualitativa realizada em um município do interior do estado de Minas Gerais, através de entrevista aberta orientada por questões disparadoras com 15 médicos da ESF. Os dados foram coletados nos meses de agosto e setembro de 2018, sendo analisados conforme o método análise de conteúdo de Bardin. Os resultados apontaram para dois eixos temáticos de análise: a importância do acolhimento e o equilíbrio do acesso entre demandas espontâneas e programadas. Concluiu-se que é de suma importância reorganizar o processo de trabalho de acordo com as necessidades da comunidade adscrita, equilibrando o atendimento entre demanda espontânea e programada, garantindo acesso ao usuário.
Structure-Based Virtual Screening towards the Discovery of Novel ULK1 Inhibitors with Anti-HCC Activities

There is an urgent need to develop new effective therapies for HCC. Our previous study identified ULK1 as the potential target for HCC therapy and screened the compound XST-14 as a specific inhibitor of ULK1 to suppress HCC progression. However, the poor manufacturability of XST-14 impeded the process of its clinical translation. In this study, we first generated pharmacophore models of ULK1 based on the X-ray structure of UKL1 in complex with ligands. We then screened the Specs chemical library for potential UKL1 inhibitors. By molecular docking, we screened out the 19 compounds through structure-based virtual screening. Through CCK8 activity screening on HCC cells, we found that ZZY-19 displayed obvious cell killing effects on HCC cells. SPR assay indicated that ZZY-19 had a higher binding affinity for ULK1 than XST-14. Moreover, ZZY-19 induced the effects of anti-proliferation, anti-invasion and anti-migration in HCC cells. Mechanistically, ZZY-19 induces autophagy inhibition by reducing the expression of ULK1 on HCC cells. Especially, the combination of ZZY-19 with sorafenib synergistically suppresses the progression of HCC in vivo. Taken together, ZZY-19 was a potential candidate compound that targeted ULK1 and possessed promising anti-HCC activities by inhibiting autophagy.