Miracle-dz/UniFAR-FTUs huggingface dataset:
Studies on Industrially Significant Haloalkaline Protease from Bacillus sp. JSGT Isolated from Decaying Skin of Tannery

Eight bacterial strains were isolated from collagen layer of decaying skin sample. Three isolates exhibited the prominent zones of clearance on skim milk agar medium at pH 9.5. These isolates were then characterized and identified. One of the haloalkalophilic isolates belonged to the genus Bacillus. Maximum enzyme activity (228.29 ± 1.89 PU/ ml) was found at pH 9 and temperature 37°C in the strain which is designated as Bacillus sp. JSGT. Basic properties such as effects of different temperature, pH, metal ions and inhibitors on protease activity were also studied. Maximum activity was obtained at pH 9 at 55°C. Ca+2 and Mg+2 ions were found to enhance the relative enzyme activity up to 158 and 136% respectively. However, the activity of protease was completely inhibited by phenyl methyl sulfonyl fluoride (PMSF) that showed its serine nature. The results indicated that enzyme produced by Bacillus sp. JSGT is active within broad ranges of temperature and pH. These characteristics render its potential use in leather and detergent industries.
A Clinical Score to Predict “Corrected Thrombolysis in Myocardial Infarction Frame Count” in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Corrected thrombolysis in myocardial infarction frame count (cTFC) is an objective, simple, and reproducible method to assess coronary blood flow which is a surrogate for cardiovascular outcomes. It is important to learn which factors are associated with cTFC. The goal of this study was to determine predictive models for epicardial blood flow assessed by cTFC and develop a diagnostic predictive model that indicates the individualized assessment of epicardial blood flow prior to primary percutaneous coronary intervention. This is a retrospective study including 3205 patients with ST-segment elevation myocardial infarction who underwent pPCI. The primary outcome was cTFC. Multivariable linear regression analysis was performed. Subsequently, a nomogram was developed to predict cTFC according to the candidate predictors. Median age was 58; the number of male patients was 2381 (74.3%). Median value of cTFC was 22 and interquartile range (IQR): 16.5–28.0). Age, diabetes mellitus (DM), total ischemic time, systolic blood pressure (SBP), heart rate (HR), and history of statin use remained in both full and reduced models. Our model may potentially allow clinicians to identify patients at high risk for impaired epicardial perfusion.
Genome-Wide Analysis of Cadmium-Induced, Germline Mutations in a Long-Term Daphnia pulex Mutation-Accumulation Experiment

Background: Germline mutations provide the raw material for all evolutionary processes and contribute to the occurrence of spontaneous human diseases and disorders. Yet despite the daily interaction of humans and other organisms with an increasing number of chemicals that are potentially mutagenic, precise measurements of chemically induced changes to the genome-wide rate and spectrum of germline mutation are lacking. Objectives: A large-scale Daphnia pulex mutation-accumulation experiment was propagated in the presence and absence of an environmentally relevant cadmium concentration to quantify the influence of cadmium on germline mutation rates and spectra. Results: Cadmium exposure dramatically changed the genome-wide rates and regional spectra of germline mutations. In comparison with those in control conditions, Daphnia exposed to cadmium had a higher overall A:T→G:C mutation rates and a lower overall C:G→G:C mutation rate. Daphnia exposed to cadmium had a higher intergenic mutation rate and a lower exonic mutation rate. The higher intergenic mutation rate under cadmium exposure was the result of an elevated intergenic A:T→G:C rate, whereas the lower exon mutation rate in cadmium was the result of a complete loss of exonic C:G→G:C mutations—mutations that are known to be enriched at 5-hydroxymethylcytosine. We experimentally show that cadmium exposure significantly reduced 5-hydroxymethylcytosine levels. Discussion: These results provide evidence that cadmium changes regional mutation rates and can influence regional rates by interfering with an epigenetic process in the Daphnia pulex germline. We further suggest these observed cadmium-induced changes to the Daphnia germline mutation rate may be explained by cadmium’s inhibition of zinc-containing domains. The cadmium-induced changes to germline mutation rates and spectra we report provide a comprehensive view of the mutagenic perils of cadmium and give insight into its potential impact on human population health. https://doi.org/10.1289/EHP8932
Improved reactivity and derivatization of cellulose after pre-hydrolysis with commercial enzymes

Reactivity is an important parameter when considering the chemical modification or dissolution of cellulose. Different pretreatment methods affect cellulose reactivity by decreasing its degree of polymerization (DP) and crystallinity. In this study, the molar mass of cellulose was decreased via enzymatic pretreatment. Three commercial endoglucanase-rich products were tested. The target was to reduce the viscosity of the pulp to below 200 mL/g and, thus, increase the reactivity of the cellulose. For comparison, cellulose was also pretreated with ozone, and the effects of each pretreatment method on crystallinity and monosaccharide composition of the resulting pulps were investigated. Both enzymatically treated and ozone-treated pulps were esterified using homogeneous and heterogeneous methods, and the degrees of substitution for these treated pulps were much higher than the esters when the untreated pulp was used. Cellulose esters from the pretreated pulps formed films with good mechanical properties by solvent casting.
Achieving 20% Efficiency for Low‐Temperature‐Processed Inverted Perovskite Solar Cells

Low‐temperature‐processed inverted perovskite solar cells (PVSCs) attract increasing attention because they can be fabricated on both rigid and flexible substrates. For these devices, hole‐transporting layers (HTLs) play an important role in achieving efficient and stable inverted PVSCs by adjusting the anodic work function, hole extraction, and interfacial charge recombination. Here, the use of a low‐temperature (≤150 °C) solution‐processed ultrathin film of poly[(9,9‐dioctyl‐fluorenyl‐2,7‐diyl)‐co‐(4,4′‐(N‐(4‐secbutylphenyl) diphenylamine)] (TFB) is reported as an HTL in one‐step‐processed CH3NH3PbI3 (MAPbI3)‐based inverted PVSCs. The fabricated device exhibits power conversion efficiency (PCE) as high as 20.2% when measured under AM 1.5 G illumination. This PCE makes them one of the MAPbI3‐based inverted PVSCs that have the highest efficiency reported to date. Moreover, this inverted PVSC also shows good stability, which can retain 90% of its original efficiency after 30 days of storage in ambient air.
Androgens and estrogens predict sexual function after autologous hematopoietic stem cell transplant in men

Autologous hematopoietic stem cell transplantation (AHSCT) is associated with sexual dysfunction and hypogonadism. Androgens are associated with sexual function in healthy men, but the role of estrogens is less well‐known, and the association of these sex steroids with sexual function during AHSCT has not been characterized.
Multidimensional Manipulation of Photonic Spin Hall Effect with a Single‐Layer Dielectric Metasurface

The photonic spin Hall effect, originating from photonic spin–orbit interactions, has attracted considerable research interest due to its potential for applications in spin‐controlled nanophotonics. However, most research efforts have focused only on 1D modulation, including transverse or longitudinal spin‐dependent splitting. Here, a novel method is proposed for multidimensional spin‐dependent splitting on a single‐layer dielectric metasurface. Due to the interplay of the Pancharatnam–Berry phase and dynamic phase, the longitudinal focusing and transverse shifting of the different spin state photons can be simultaneously achieved. Moreover, the conjugated characteristic of the modulated phases of Pancharatnam–Berry phase metasurfaces for different spin photons can be broken, and both symmetric and asymmetric transverse spin‐dependent splitting are obtained with the proposed method. This method can be used for the multidimensional and flexible manipulation of spin photons and has potential in spin‐controlled nanophotonics, ranging from optical communication to beam shaping and optical sensors.
Pulsed low-energy stimulation initiates electric turbulence in cardiac tissue

Interruptions in nonlinear wave propagation, commonly referred to as wave breaks, are typical of many complex excitable systems. In the heart they lead to lethal rhythm disorders, the so-called arrhythmias, which are one of the main causes of sudden death in the industrialized world. Progress in the treatment and therapy of cardiac arrhythmias requires a detailed understanding of the triggers and dynamics of these wave breaks. In particular, two very important questions are: 1) What determines the potential of a wave break to initiate re-entry? and 2) How do these breaks evolve such that the system is able to maintain spatiotemporally chaotic electrical activity? Here we approach these questions numerically using optogenetics in an in silico model of human atrial tissue that has undergone chronic atrial fibrillation (cAF) remodelling. In the lesser studied sub-threshold illumination régime, we discover a new mechanism of wave break initiation in cardiac tissue that occurs for gentle slopes of the restitution characteristics. This mechanism involves the creation of conduction blocks through a combination of wavefront-waveback interaction, reshaping of the wave profile and heterogeneous recovery from the excitation of the spatially extended medium, leading to the creation of re-excitable windows for sustained re-entry. This finding is an important contribution to cardiac arrhythmia research as it identifies scenarios in which low-energy perturbations to cardiac rhythm can be potentially life-threatening.
SiO2-Coated Molecularly Imprinted Copolymer Nanostructures for the Adsorption of Bisphenol A

Molecularly imprinted hybrids (MIHs) were prepared by imprinting bisphenol A (BPA) molecules with linear polystyrene-co-methyl methacrylate chains followed by anchoring SiO2 clusters onto the imprinted organic moieties. While the interior copolymer was responsible for BPA rebinding, the external SiO2 layer confined the conformation of the copolymer, suppressed the nonspecific hydrophobic interactions, and enhanced the water compatibility of copolymer. Styrene and methyl methacrylate (MMA) were used as the dual functional monomers to interact with the BPA templates via π–π stacking interaction and formation of hydrophobic backbones, respectively. The optimal composition molar ratio of BPA/styrene/MMA/3-methacryloxylpropyltrimethoxysilane/tetraethyl orthosilicate with respect to the most satisfied adsorption ability was 1/2/5/5/15. The resulting MIH compound exhibited a superior adsorption performance, including a high imprinting factor of 14, a high adsorption capacity of 40.3 mg/g, a large association con.
Both plasma basic carboxypeptidases, carboxypeptidase B2 and carboxypeptidase N, regulate vascular leakage activity in mice

Kallikrein is generated when the contact system is activated, subsequently cleaving high molecular weight kininogen to bradykinin (BK). BK binds to bradykinin receptor 2, causing vascular leakage. BK is inactivated by proteolysis by the plasma carboxypeptidase B2 and N (CPB2 and CPN). CPN is constitutively active but CPB2 is generated from its zymogen, proCPB2.
Cardiolipin function in the yeast S. cerevisiae and the lessons learned for Barth syndrome

Cardiolipin (CL) is the signature phospholipid (PL) of mitochondria and plays a pivotal role in mitochondrial and cellular function. Disruption of the CL remodeling gene tafazzin (TAZ) causes the severe genetic disorder Barth syndrome (BTHS). Our current understanding of the function of CL and the mechanism underlying the disease has greatly benefited from studies utilizing the powerful yeast model Saccharomyces cerevisiae. In this review, we discuss important findings on the function of CL and its remodeling from yeast studies and the implications of these findings for BTHS, highlighting the potential physiological modifiers that may contribute to the disparities in clinical presentation among BTHS patients.
Dietary supplements for consideration in elite female footballers

The physical demands of professional female football have intensified in recent years. Supplements are only advised in addition to a healthy, balanced diet, but may warrant a greater prevalence in the professional game to support well-being, recovery and performance. Supplements used by players should be safe, legal and scientifically proven to be effective. An individual approach should be taken to using supplements dependant on the needs and goals of the player. Female players should aim to improve the frequency of protein intake throughout the day, whilst tailoring doses to individual body mass. Vitamin D supplementation is vital throughout the winter months in countries with limited sun exposure, however doses should be administered based on individual blood test results. Iron is likely to be important to the well-being of female athletes throughout the season, in particular during the menses. Omega-3 and collagen may be of greater benefit to female than male athletes during recovery from soft tissue injury, whilst probiotics and creatine are beneficial throughout the season for reducing risk of illness and optimising recovery, respectively. Ergogenic supplements for football include beta-alanine, nitrate and caffeine. Caution should be taken with caffeine use due to the varying tolerance of difference athletes and sleep impairments that can follow.
Physicians' and pharmacists' views and experiences regarding use of direct oral anticoagulants in clinical practice

Direct oral anticoagulants (DOACs) are increasingly used compared to vitamin K antagonists (VKAs). Guidelines advocate a structured multidisciplinary approach in the management of patients treated with DOACs. The aim of this study was to assess the views and experiences of physicians and pharmacists regarding DOAC use in clinical practice.
Assessment of microbiological, physicochemical, water-soluble anions and elemental contents of water and sediments of Bon Accord Dam, South Africa

Abstract Due to the scarcity of water resources, South Africa is mainly dependent on water stored in man-made reservoirs for urban, industrial and irrigation purposes. Hence, the quality of the water in these dams is important. The microbiological, physicochemical and elemental quality of water and sediment of Bon Accord Dam, South Africa were studied. The total coliform and Escherichia coli were measured, the physicochemical parameters were determined in situ and elemental analyses were carried out. The water from some sampling sites had pH>8.4, which could affect crop quality and yield. The electrical conductivity and total dissolved solid values implied that the water was of medium salinity where sensitive crops could be affected. The measured physicochemical parameters were within the national and/or international guidelines for irrigation water even if some of the parameters may have a negative impact on selected crops. The anion concentration in the water followed the order SO42->Cl−>PO43->NO3−>Br−>NO2−>F−. The concentrations of the water-soluble anions (except PO43- and at some sites NO3−) in samples were within their respective South African and/or WHO guidelines for irrigation water. However, the levels of PO43- in this study were ≥0.130 mg/L makes the dam hypertrophic. The average concentration of potentially toxic elements in the sediments of the dam was found to be moderately to heavily polluted by Cr and Ni, non-polluted to moderately polluted by Cu and non-polluted by Pb and Zn. The bacterial levels in the dam were low and can hence not be considered a problem.
A New Hand-Movement-Based Authentication Method Using Feature Importance Selection with the Hotelling’s Statistic

Abstract The growing amount of collected and processed data means that there is a need to control access to these resources. Very often, this type of control is carried out on the basis of bio-metric analysis. The article proposes a new user authentication method based on a spatial analysis of the movement of the finger’s position. This movement creates a sequence of data that is registered by a motion recording device. The presented approach combines spatial analysis of the position of all fingers at the time. The proposed method is able to use the specific, often different movements of fingers of each user. The experimental results confirm the effectiveness of the method in biometric applications. In this paper, we also introduce an effective method of feature selection, based on the Hotelling T2 statistic. This approach allows selecting the best distinctive features of each object from a set of all objects in the database. It is possible thanks to the appropriate preparation of the input data.
Modelling of Drag Force Reduction for a Waterjet Propulsion System

Abstract The paper provides simulation results for SUP (Stand Up Paddle) board appendage resistance. Additional propulsion is added to the SUP board. It is equipped with a waterjet. The waterjet is attached to the board rudder. This increases the drag coefficient for rudder five times. To reduce the drag variable, design options for the waterjet duct were proposed. The simulation tests were performed using SolidWorks Flow software using two types of simulations, namely, the pressure on the body and the flow around the body. The objective was to streamline the bluff duct of the waterjet and thus to create the appendage design with minimum drag force from fluid flow and possibly greater Inlet Velocity Ratio. Calculations showed that rounding-off the edges of waterjet duct resulted in 35 % of drag coefficient reduction, while further streamlining reduced it by additional 10 %.
Effect Of L-Cysteine On Blood Picture And Some Serum Parameters In Rats Exposed To 2 Gauss Electro-Magnetic Field

Objective: investigation of the bio-effects of exposure to 2 gauss electromagnetic field (EMF) on blood elements, blood glucose, hepatocellular enzymes and bilirubin of mice and their possible modification by L-cysteine. Methods: the following groups were studied; (1) normal rats treated with saline; (2) normal rats treated with L-cysteine (18 mg/kg); (3) rats exposed to EMF for 21 days and treated with the vehicle (saline) during the exposure period; (4) rats exposed to EMF for 21 days and treated with L-cysteine (18 mg/kg orally, 3 times per week) during the exposure period; (5) rats exposed to EMF for 21 days and treated with the vehicle (saline) during the exposure period and for 45 days after exposure; (6) rats exposed to EMF for 21 days and treated with L-cysteine (18 mg/kg orally, 3 times per week) during the exposure period and for 45 days after exposure; Results: in rats exposed to low frequency EMF for 21 days (group2), marked increase in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities in serum was observed. Plasma bilirubin level was raised. Meanwhile, significant decrease in plasma glucose levels occured after exposure to EMF. No significant changes were observed in haemoglobin level, red blood cells or total leucocytic count noted in rats exposed to EMF. The elevations in serum bilirubin, AST and ALT levels were reduced to near normal values in rats given L-cysteine druing the 21 days of exposure (group3). On the other hand, in rats examined 45 days after the end of the exposure period (group 3), no significant alterations were noted as regards bilirubin, AST, ALT and glucose levels in serum. Conclusions: these results suggest that (1) exposure to low frequency EMF of 50 Hz is associated with some degree of liver injury reflected in increased leakage of hepatoceular enzymes into plasma as well as an increase in serum bilirubin; (2) these alterations can be ameliorated by the administration of L-cysteine, as well as; (3) by limiting exposure to EMF.
Knowledge Driven Paper Recommendation Using Heterogeneous Network Embedding Method

We search a variety of things over the Internet in our daily lives, and numerous search engines are available to get us more relevant results. With the rapid technological advancement, the internet has become a major source of obtaining information. Further, the advent of the Web2.0 era has led to an increased interaction between the user and the website. It has become challenging to provide information to users as per their interests. Because of copyright restrictions, most of existing research studies are confronting the lack of availability of the content of candidates recommending articles. The content of such articles is not always available freely and hence leads to inadequate recommendation results. Moreover, various research studies base recommendation on user profiles. Therefore, their recommendation needs a significant number of registered users in the system. In recent years, research work proves that Knowledge graphs have yielded better in generating quality recommendation results and alleviating sparsity and cold start issues. Network embedding techniques try to learn high quality feature vectors automatically from network structures, enabling vector-based measurers of node relatedness. Keeping the strength of Network embedding techniques, the proposed citation-based recommendation approach makes use of heterogeneous network embedding in generating recommendation results. The novelty of this paper is in exploiting the performance of a network embedding approach i.e., matapath2vec to generate paper recommendations. Unlike existing approaches, the proposed method has the capability of learning low-dimensional latent representation of nodes (i.e., research papers) in a network. We apply metapath2vec on a knowledge network built by the ACL Anthology Network (all about NLP) and use the node relatedness to generate item (research article) recommendations.
Determining the Kinetic’s Coefficients in Treatment of Sugarcane Industry Using Aerobic Activated Sludge by Complete-Mix Regime

Department of Environmental Engineering, Science an d Research Branch, Islamic Azad University, Khouzes tan, Iran * Assistant Professor, Environmental Technologies Res earch Center, Ahvaz Jundishapur University of Medic al Sciences, Ahvaz, Iran Department of Environmental Engineering, Science an d Research Branch, Islamic Azad University, Tehran, Iran Department of Medicinal Chemistry (Pharmaceutical S ciences Research Center), Pharmaceutical Sciences B ranch, Islamic Azad University, Tehran, Iran ________________________________________________________________________________________