Miracle-dz/UniFAR-FTUs huggingface dataset:
ASSESSING HEALTH- RELATED QUALITY OF LIFE (QOL) IN RHEUMATOID ARTHRITIS

Quality of life (QoL) has become an important issue in health care, especially in the studies of chronic diseases. It is a concept incorporating all the factors that might impact on an individual’s life. WHO defines health as ‘a state of complete physical, mental and social well-being, and not merely the absence of disease and infirmity. The quality of life is usually measured using an instrument in the form of a questionnaire. The various issues to consider when attempting to measure quality of life are: ‘what questions should be asked, how responses be recorded, when should questions be asked, of whom should questions be asked and who should do the asking’. The questionnaire generally comprises sets of questions or items relating to the various dimensions of quality of life, such as physical, psychological or social. The format of responses may be ‘yes/no’, a series of ordered categories, or a linear analogue scale. Rheumatoid arthritis is a chronic debilitating disease, which has a detrimental effect on various aspects of life, including physical, psychological and social functioning. The ultimate aim of any therapy for RA should therefore be not only to improve symptoms and functional abilities but also to achieve a better overall quality of life. In order to assess QoL adequately in RA patients, the instrument that is used should be derived from the experiences of the patients themselves, and should be specific to the disease, simple to administer and complete and acceptable to the respondents. The Health Assessment Questionnaire (HAQ), Nottingham Health Profile (NHP), Sickness Impact profile (SIP), and Short Form Health Survey -36 (SF-36) are some of the generic instruments widely used in population studies. In this review, we will briefly look at the various health related questionnaires and scores employed in assessing Health- Related Quality of Life (QoL) in Rheumatoid Arthritis.
Cytomegalovirus Antigens Immunodominance Hierarchy of The Context of Gene Expression Defines the

Natural immunity to CMV dominates the CD4 and CD8 memory compartments of the CMV-seropositive host. This property has been recently exploited for experimental CMV-based vaccine vector strategies, and it has shown promise in animal models of AIDS and Ebola disease. Although it is generally agreed that CMV-based vaccine vectors may induce highly protective and persistent memory T cells, the inﬂuence of the gene expression context on Ag-speciﬁc T cell memory responses and immune protection induced by CMV vectors is not known. Using murine CMV (MCMV) recombinants expressing a single CD8 T cell epitope from HSV-1 fused to different MCMV genes, we show that magnitude and kinetics of T cell responses induced by CMV are dependent on the gene expression of CMV Ags. Interestingly, the kinetics of the immune response to the HSV-1 epitope was paralleled by a reciprocal depression of immune responses to endogenous MCMVAgs. Infection with a recombinant MCMV inducing a vigorous initial immune response to the recombinant peptide resulted in a depressed early response to endogenous MCMVAg. Another recombinant virus, which induced a slowly developing “inﬂationary” T cell response to the HSV-1 peptide, induced weaker long-term responses to endogenous CMV Ags. Importantly, both mutants were able to protect mice from a challenge with HSV-1, mediating strong sterilizing immunity. Our data suggest that the context of gene expression markedly inﬂuences the T cell immunodominance hierarchy of CMV Ags, but the immune protection against HSV-1 does not require inﬂationary CD8 responses against the recombinant CMV-expressed epitope. The Journal of Immunology , 2013, 190: 000–000.
The potential role of spinal ketamine multi-component antinociception Ph.D. Thesis

Joo G. , Szikszay M. , Horvath G. , Kekesi G. , Benedek G. The antinociceptive potency of endomorphin-1 and-2 in rats. 7 Annual Meeting of European Society ofAnaesthesiologists. 28f May I' June 1999. Amsterdam (Oral presentation) Pub. :British J. Anaesth. 82 (Sl):201,1999. Impact factor: 2.205 Joo G. , Horvath G. , Kekesi G. , Klimscha W. , Szikszay M. , Benedek G. S(+)-ketamine potentiates and prolonges the moiphine-induced antinociception after intrathecal administration in rats. Second European Congress of Pharmacology (Ephar'99), Budapest, 3-7. July 1999. (Poster) Pub. : Fundamental&Clinical Pharmacology vol.13/suppl.l 1999. 211s Impact factor: 1.036 Horvath G. , Joo G. , Klimscha W. , Dobos I. , Szikszay M. , Benedek G. The interaction of S(+)-ketamine with dexmedetomidine after intrathecal administration in rats. Annual Meeting of European Society of Anaesthesiologists 1-4 April 2000. Vienna (Oral presentation) Pub. : Eur. J. of Anaesthesiol. , voll7 (S19): 176-177. 2000 Impact factor: 0.966
Inhibition of Heavy Chain and (cid:2) 2 -Microglobulin Synthesis as a Mechanism of Major Histocompatibility Complex Class I Downregulation during Epstein-Barr Virus Replication (cid:1)

The mechanisms of major histocompatibility complex (MHC) class I downregulation during Epstein-Barr virus (EBV) replication are not well characterized. Here we show that in several cell lines infected with a recombinant EBV strain encoding green ﬂuorescent protein (GFP), the virus lytic cycle coincides with GFP expression, which thus can be used as a marker of virus replication. EBV replication resulted in downregulation of MHC class II and all classical MHC class I alleles independently of viral DNA synthesis or late gene expression. Although assembled MHC class I complexes, the total pool of heavy chains, and (cid:1) 2 -microglobulin ( (cid:1) 2 m) were signiﬁcantly downregulated, free class I heavy chains were stabilized at the surface of cells replicating EBV. Calnexin expression was increased in GFP (cid:2) cells, and calnexin and calreticulin accumulated at the cell surface that could contribute to the stabilization of class I heavy chains. Decreased expression levels of another chaperone, ERp57, and TAP2, a transporter associated with antigen processing and presentation, correlated with delayed kinetics of MHC class I maturation. Levels of both class I heavy chain and (cid:1) 2 m mRNA were reduced, and metabolic labeling experiments demonstrated a very low rate of class I heavy chain synthesis in lytically infected cells. MHC class I and MHC class II downregulation was mimicked by pharmacological inhibition of protein synthesis in latently infected cells. Our data suggest that although several mechanisms may contribute to MHC class I downregulation in the course of EBV replication, inhibition of MHC class I synthesis plays the primary role in the process.
A phytoplankton population actively diversifies its migration strategy 1 in response to turbulent cues

13 14 Marine phytoplankton inhabit a dynamic environment where turbulence, together with 15 nutrient and light availability, shapes species fitness, succession, and selection 1,2 . Many 16 species of phytoplankton are motile and undertake diel vertical migrations to gain 17 access to nutrient-rich deeper layers at night and well-lit surface waters during the 18 day 3,4 . Disruption of this migratory strategy by turbulence is considered to be an important cause of the succession between motile and non-motile species when 20 conditions turn turbulent 1,5,6 . However, this classical view neglects the possibility that 21 motile species may actively respond to turbulent cues, in order to avoid layers of strong 22 turbulence 7 . Here we report that a population of the harmful-algal-bloom forming 23 raphidophyte Heterosigma akashiwo actively diversifies its migratory strategy in 24 response to hydrodynamic cues characteristic of overturning by Kolmogorov-scale 25 eddies. Upon experiencing repeated overturning with timescales and statistics 26 representative of ocean turbulence, an upward swimming population rapidly (5–60 27 min) splits into two subpopulations, one swimming upward and one swimming 28 downward. Quantitative morphological analysis together with a model of cell 29 mechanics revealed that this behaviour was accompanied by a modulation of the cells’ 30 fore-aft asymmetry. The minute magnitude of the required modulation, sufficient to 31 invert the cells’ preferential swimming direction, highlights the advanced level of 32 control that phytoplankton can exert on their migratory behaviour. Together with 33 observations of enhanced cellular stress
Measurement of the J/ψ production in p-Pb collisions at the LHC with the ALICE muon spectrometer

Hard probes represent one of the hottest topics of the modern high energy physics. The production mechanism of quarkonia (mesons composed of a charm or beauty quark and its antiquark) in hadronic collisions is of particular interest. The suppression of J/ψ and other charmonium states was predicted as one of the first signatures of the Quark Gluon Plasma (QGP) formation and was seen at RHIC and SPS. It was also studied at the LHC in Pb-Pb collisions. However, other effects can affect the charmonium production in Pb-Pb collisions without the presence of the QGP. These effects are inherent to the use of nuclei and are called «Cold Nuclear Matter» (CNM) effects. They can be studied in p-Pb collisions. This thesis is dedicated to the studies of J/ψ production in p-Pb collisions at the LHC at a center of mass energy of 5.02 TeV per nucleon pair. J/ψ production is studied as a function of transverse momentum, rapidity and event activity. These results represent a significant step to better understanding of the CNM effects and to the establishment of a reference for J/ψ production in Pb-Pb collisions.
PGPM_A_337147 1603..1617

1University of Newcastle, Newcastle, NSW, Australia; 2Hunter Cancer Research Alliance, Hunter Medical Research Institute, Newcastle, NSW, Australia; 3Division of Molecular Medicine, Pathology North John Hunter Hospital, Newcastle, NSW, Australia; 4Hunter Cancer Centre, Lake Macquarie Private Hospital, Gateshead, NSW, Australia Abstract: Pharmacogenomic screening can identify patients with gene variants that predispose them to the development of severe toxicity from fluoropyrimidine (FP) chemotherapy. Deficiency of the critical metabolic enzyme dihydropyrimidine dehydrogenase (DPD) leads to excessive toxicity on exposure to fluoropyrimidine chemotherapy. This can result in hospitalisation, intensive care admissions and even death. Upfront screening of the gene that encodes for DPD (DPYD) has recently been implemented in regions throughout Europe and the United Kingdom. Current screening evaluates DPYD variants that are well described within Caucasian patient populations and provides genotyped-guided dose adjustment recommendations based upon the presence of these variants. This article reviews the differences in DPYD gene variants within non-Caucasian populations compared to Caucasian populations, with regard to the implications for clinical tolerance of fluoropyrimidine chemotherapies and genotype guided dose adjustment guidelines.
A Synoptic Survey of Social Network Mental Disorder Identification via Social Media Mining

- The strongest weapon to conquer the knowledge in today’s world - “Internet” , has unfortu nately turned out to be one of our greatest obsessions in killing time and is affecting our daily activities and responsibilities with a massive desire to get rid of everything to be able to 'Netflix and relax' all the time. Though the ‘Internet Addiction’ is gaining attention in the mental health field and had been recently added to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) as a disorder, it needs a lot of research and standardized diagnosis. Their detection at an early stage is extremely important because the clinical interventions only during the last stage will make things worse and critical. In this paper, we argue that the potential Social Network Mental Disorder (SNMD) users can be automatically identified and classified into various categories like Virtual Relationship Addiction, Obsessive Online Gambling and Information Glut using SNMD based tensor model, with the data sets collected from data logs of various Online Social Networks (OSNs). The proposed model stands out in the list as the users are not involved in revealing their habits to understand and diagnose the symptoms manually. We also exploit multi-source learning in SNMDI (Social Network Mental Disorder Identification) and propose a new SNMD-based Tensor Model (STM) to improve the accuracy. The results show that SNMDI is reliable for identifying online social network users with potential SNMDs.
Evidence for shock-shock interaction in the jet of CTA 102

Abstract We have found evidence for interaction between a standing and a traveling shock in the jet of the blazar CTA 102. Our result is based in the study of the spectral evolution of the turnover frequency-turnover flux density (νm, Sm) plane. The radio/mm light curves were taken during a major radio outburst in April 2006.
Marine and coastal ecosystem services on the science–policy–practice nexus: challenges and opportunities from 11 European case studies challenges

We compared and contrasted 11 European case studies to identify challenges and opportunities toward the operationalization of marine and coastal ecosystem service (MCES) assessments in Europe. This work is the output of a panel convened by the Marine Working Group of the EcosystemServicesPartnership inSeptember 2016.The MCES assessments were used to (1) address multiple policy objectives simultaneously, (2) interpret EU-wide policies to smaller scales and (3) inform local decision-making. Most of the studies did inform decision makers, but only in a few cases, the outputs were applied or informed decision-making. Significant limitations among the 11 assessments were the absence of shared understanding of the ES concept, data and knowledge gaps, difficulties in accounting for marine social – ecological systems complexity and partial stakeholder involvement. The findings of the expert panel call for continuous involvement of MCES ‘ end users ’ , integrated knowledge on marine social – ecological systems, defining thresholds to MCES use and raising awareness to the general public. Such improvements at the intersection of science, policy and practice are essential starting points toward building a stronger science foundation supporting management of European marine ecosystems.
Institutional Knowledge at Singapore Management University

—A common characteristic of modern web browsers is that their functionality can be extended via third-party add-ons. In this paper we focus on Chrome extensions , to which the Chrome browser exports a rich API: extensions can potentially make network requests, access the local ﬁle system, get low-level information about running processes, etc. To guard against misuse, Chrome uses a permission system to curtail an extension’s privileges. We demonstrate a series of attacks by which extensions can steal data, track user behavior, and collude to elevate their privileges. Although some attacks have previously been reported, we show that subtler versions can easily be devised that are less likely to be prevented by proposed defenses and can evade notice by the user. We quantify the potential danger of attacks by examining how many currently available extensions have sufﬁcient privileges to carry them out. As many web sites do not employ defenses against such attacks, we examine how many popular web sites are vulnerable to each kind of attack. Our results show that a surprisingly large fraction of web sites is vulnerable to many attacks, and a large fraction of currently available extensions is potentially able to carry them out.
Cold Tolerance of C 4 photosynthesis in Miscanthus 3 giganteus : Adaptation in Amounts and Sequence of C 4 Photosynthetic Enzymes 1

Field-grown Miscanthus 3 giganteus maintains high photosynthetic quantum yields and biomass productivity in cool temperate climates. It is related to maize ( Zea mays ) and uses the same NADP-malic enzyme C 4 pathway. This study tests the hypothesis that M. 3 giganteus , in contrast to maize, forms photosynthetically competent leaves at low temperatures with altered amounts of pyruvate orthophosphate dikinase (PPDK) and Rubisco or altered properties of PPDK. Both species were grown at 25°C/20°C or 14°C/11°C (day/night), and leaf photosynthesis was measured from 5°C to 38°C. Protein and steady-state transcript levels for Rubisco, PPDK, and phospho enol pyruvate carboxylase were assessed and the sequence of C 4 -PPDK from M. 3 giganteus was compared with other C 4 species. Low temperature growth had no effect on photosyn- thesis in M. 3 giganteus , but decreased rates by 80% at all measurement temperatures in maize. Amounts and expression of phospho enol pyruvate carboxylase were affected little by growth temperature in either species. However, PPDK and Rubisco large subunit decreased . 50% and . 30%, respectively, in cold-grown maize, whereas these levels remained unaffected by temperature in M. 3 giganteus . Differences in protein content in maize were not explained by differences in steady-state transcript levels. Several different M. 3 giganteus C 4 -PPDK cDNA sequences were found, but putative translated protein sequences did not show conservation of amino acids contributing to cold stability in Flaveria brownii C 4 -PPDK. The maintenance of PPDK and Rubisco large subunit amounts in M. 3 giganteus is consistent with the hypothesis that these proteins are critical to maintaining high rates of C 4 photosynthesis at low temperature. replicate blot, of normalized the one- our hypothesis was that amounts of these enzymes with cold or remain the same, relative to warm temperatures.
COEXISTING WITH CHINA IN THE 21 ST CENTURY*

Since Deng Xiaoping and reformers Hu Yaobang and Zhao Ziyang launched radical market reforms in China, the country became a capitalist economic system with a communist political regime, a regime never observed before in history. We discuss the nature of that regime, how stable it is likely to be over time and what the challenges are for democracies of international coexistence with this new regime in the twenty ﬁ rst century.
Nanomagnetism in Otherwise Nonmagnetic Materials

This is a 20% excerpt of the manuscript entitled Nanomagnetism in Otherwise Nonmagnetic Materials which has been reviewed and approved for the publication in Handbook of Nanophysics (HNP), 7 Volumes, 300 Chapters Klaus D. Sattler, Editor, Taylor&Francis Publisher (CRC Press). In the present version the Introduction, Tutorial, Figures, Tables, critical analysis and Conclusions are omitted. The manuscript may serve as a source of references. The 20% excerpt is placed on cond-mat ArXiv under the permission of Taylor & Francis Group LLC.
A Hierarchical Concept of Ecosystems.

"Ecosystem" is an intuitively appealing concept to most ecologists, but, in spite of its widespread use, the term remains diffuse and ambiguous. The authors of this book argue that previous attempts to define the concept have been derived from particular viewpoints to the exclusion of others equally possible. They offer instead a more general line of thought based on hierarchy theory. Their contribution should help to counteract the present separation of subdisciplines in ecology and to bring functional and population/community ecologists closer to a common approach. Developed as a way of understanding highly complex organized systems, hierarchy theory has at its center the idea that organization results from differences in process rates. To the authors the theory suggests an objective way of decomposing ecosystems into their component parts. The results thus obtained offer a rewarding method for integrating various schools of ecology.
Effect of a Steady Flow and an Atmospheric Magnetic Field on the Solar p- and f-Modes

The combined effect of a subsurface steady homogeneous flow and a chromospheric uniform magnetic field on the solar p- and f-modes is evaluated theoretically for a simple model of the Sun. The derived dispersion relation is solved analytically in limit of the long wave-length approximation and is evaluated numerically for arbitrary wavelengths. The influence of an equilibrium flow is more dominant in limit of small wavenumbers. For arbitrary wavelengths the effect of a magnetic field might be stronger than frequency shifts caused by a steady homogeneous flow.
Suicide and Suicidal Behavior The Harvard made this article share you. Your

Suicidal behavior is a leading cause of injury and death worldwide. Information about the epidemiology of such behavior is important for policy-making and prevention. The authors reviewed government data on suicide and suicidal behavior and conducted a systematic review of studies on the epidemiology of suicide published from 1997 to 2007. The authors' aims were to examine the prevalence of, trends in, and risk and protective factors for suicidal behavior in the United States and cross-nationally. The data revealed significant cross-national variability in the prevalence of suicidal behavior but consistency in age of onset, transition probabilities, and key risk factors. Suicide is more prevalent among men, whereas nonfatal suicidal behaviors are more prevalent among women and persons who are young, are unmarried, or have a psychiatric disorder. Despite an increase in the treatment of suicidal persons over the past decade, incidence rates of suicidal behavior have remained largely unchanged. Most epidemiologic research on suicidal behavior has focused on patterns and correlates of prevalence. The next generation of studies must examine synergistic effects among modifiable risk and protective factors. New studies must incorporate recent advances in survey methods and clinical assessment. Results should be used in ongoing efforts to decrease the significant loss of life caused by suicidal behavior.
Kinetics of active K -glucoside transport in Saccharomyces cerevisiae

K -Glucosides are the most abundant fermentable sugars in the industrial applications of Saccharomyces cerevisiae , and the active transport across the plasma membrane is the rate-limiting step for their metabolism. In this report we performed a detailed kinetic analysis of the active K -glucoside transport system(s) present in a wild-type strain, and in strains with defined K -glucoside permeases. Our results indicate that the wild-type strain harbors active transporters with high and low affinity for maltose and trehalose, and low-affinity transport systems for maltotriose and K -methylglucoside. The maltose permease encoded by the MAL21 gene showed a high affinity ( K m V 5 mM) for maltose, and a low affinity ( K m V 90 mM) for trehalose. On the other hand, the K -glucoside permease encoded by the AGT1 gene had a high affinity ( K m V 7 mM) for trehalose, a low affinity ( K m V 18 mM) for maltose and maltotriose, and a very low affinity ( K m V 35 mM) for K -methylglucoside. (cid:223) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. rights reserved.