Miracle-dz/UniFAR-FTUs huggingface dataset:
Fermentation-induced variation in heat and oxidative stress phenotypes of Lactococcus lactis MG 1363 reveals transcriptome signatures for robustness

Background: Lactococcus lactis is industrially employed to manufacture various fermented dairy products. The most cost-effective method for the preservation of L. lactis starter cultures is spray drying, but during this process cultures encounter heat and oxidative stress, typically resulting in low survival rates. However, viability of starter cultures is essential for their adequate contribution to milk fermentation, supporting the ambition to better understand and improve their robustness phenotypes. Results: This study describes a transcriptome-phenotype matching approach in which the starter L. lactis MG1363 was fermented under a variety of conditions that differed in the levels of oxygen and/or salt, as well as the fermentation pH and temperature. Samples derived from these fermentations in the exponential phase of bacterial growth were analyzed by full-genome transcriptomics and the assessment of heat and oxidative stress phenotypes. Variations in the fermentation conditions resulted in up to 1000-fold differences in survival during heat and oxidative stress. More specifically, aeration during fermentation induced protection against heat stress, whereas a relatively high fermentation temperature resulted in enhanced robustness towards oxidative stress. Concomitantly, oxygen levels and fermentation temperature induced differential expression of markedly more genes when compared with the other fermentation parameters. Correlation analysis of robustness phenotypes and gene expression levels revealed transcriptome signatures for oxidative and/or heat stress survival, including the metC-cysK operon involved in methionine and cysteine metabolism. To validate this transcriptome-phenotype association we grew L. lactis MG1363 in the absence of cysteine which led to enhanced robustness towards oxidative stress. Conclusions: Overall, we demonstrated the importance of careful selection of fermentation parameters prior to industrial processing of starter cultures. Furthermore, established stress genes as well as novel genes were associated with robustness towards heat and/or oxidative stress. Assessment of the expression levels of this group of genes could function as an indicator for enhanced selection of fermentation parameters resulting in improved robustness during spray drying. The increased robustness after growth without cysteine appeared to confirm the role of expression of the metC-cysK operon as an indicator of robustness and suggests that sulfur amino acid metabolism plays a pivotal role in oxidative stress survival.
Development and Psychometric Assessment of Triage Nurses' Professional Capability Questionnaire in Emergency Department

Background: Evaluation of triage nurses' professional capability is integral to identifying areas of professional development and nurses' educational needs, thus the need for valid instruments for assessment of professional capability. The present study aims to develop and measure the reliability and validity of a triage nurses' professional capability questionnaire. Methods: The present study is an exploratory work of research conducted in two stages: in the first stage (the qualitative phase), through conventional content analysis, the concept of professional capability in triage nurses was defined and the items of the questionnaire were developed. In the second stage (the quantitative phase), the psychometric properties of the questionnaire were assessed through analyses of its face validity, content validity, construct validity, internal homogeneity, and consistency. Results: The primary item pool contained 90 items while the final scale consisted of 35 items. The S-CVI/Ave of the questionnaire was found to be 0.96. An exploratory factor analysis showed the factor loading of the items to be between 0.478 and 0.897, all of which values were significant, and the three dimensions introduced in the main instrument were verified with acceptable values. The overall interclass correlation of the instrument was found to be 0.90. The reliability of the instrument was assessed in terms of its internal homogeneity where the Cronbach's alpha of the entire instrument was found to be 0.89. Conclusions: The results show that the questionnaire developed for assessment of triage nurses' professional capability is sufficiently reliable and valid and can be employed by nurse administrators toward evaluation of triage nurses' professional capability.
UvA-DARE ( Digital Academic Repository ) Unique roles of mothering and fathering in child anxiety : moderation by child ’ s age and gender

We examined the associations between the parenting dimensions autonomy granting, over control, and rejection and children’s anxiety, in relation to parent and child gender and child age. Elementary school-aged children (n = 179, Mage = 10.27, SD = 1.30), adolescents (n = 127, Mage = 15.02, SD = 1.54) and both their parents completed questionnaires on parenting and children’s anxiety. Parenting was more strongly related to child anxiety in elementary school children than in adolescents. Maternal over control was uniquely related to elementary school-aged children’s anxiety whereas paternal over control was more important during adolescence. Opposite to our expectations, we found higher levels of parental autonomy granting to be related to higher levels of anxiety for younger elementary school-aged children (age \ 10). For adolescents, the association between paternal over control and anxiety was stronger for older adolescents (age [ 15), with higher levels of over control related to higher levels of anxiety. For both elementary school-aged children and adolescents, the associations between parenting and child anxiety did not differ as a function of the child’s gender. If we are to understand the associations between parenting and children’s anxiety, it is important to distinguish parental autonomy granting from parental over control and to consider the role of parent gender and the age of the child.
An Improved Parameter Identification Method forThree Phase Induction Motor

In order to improve the control performance of vector inverter, an improved parameter identification solution for induction motor is proposed in this paper. Dc or AC voltage is applied to the induction motor using the SVPWM through the inverter. Then stator resistance, stator leakage inductance, rotor resistance, rotor leakage inductance and mutual inductance are obtained according to the signal response. The discrete Fourier transform (DFT) is used to deal with the noise and harmonic. The impact on parameter identification caused by delays in the inverter switch tube, tube voltage drop and deadtime is avoided by effective compensation measures. Finally, the parameter identification experiment is conducted based on the vector inverter which using TMS320F2808 DSP as the core processor and results show that the strategy is verified.
Acoustic wave sparsely activated localization microscopy (AWSALM): Super-resolution ultrasound imaging using acoustic activation and deactivation of nanodroplets

Photo-activated localization microscopy (PALM) has revolutionized the field of fluorescence microscopy by breaking the diffraction limit in spatial resolution. In this study, “acoustic wave sparsely activated localization microscopy (AWSALM),” an acoustic counterpart of PALM, is developed to super-resolve structures which cannot be resolved by conventional B-mode imaging. AWSALM utilizes acoustic waves to sparsely and stochastically activate decafluorobutane nanodroplets by acoustic vaporization and to simultaneously deactivate the existing vaporized nanodroplets via acoustic destruction. In this method, activation, imaging, and deactivation are all performed using acoustic waves. Experimental results show that sub-wavelength micro-structures not resolvable by standard B-mode ultrasound images can be separated by AWSALM. This technique is flow independent and does not require a low concentration of contrast agents, as is required by current ultrasound super resolution techniques. Acoustic activation and deactivation can be controlled by adjusting the acoustic pressure, which remains well within the FDA approved safety range. In conclusion, this study shows the promise of a flow and contrast agent concentration independent super-resolution ultrasound technique which has potential to be faster and go beyond vascular imaging.
UvA-DARE (Digital Academic Repository) Objective and subjective voice outcomes after total laryngectomy a systematic review

rehabilitation groups reported clearly better outcomes in patient-reported outcomes. Conclusions Studies on speech outcomes after TL are flawed in design and represent weak levels of evidence. There is an urge for standardized measurement tools for evaluations of substitute voice speakers. TES is the favorable speech rehabilitation method according to acoustic and perceptual outcomes. All speaker groups after TL report a degree of voice handicap. Knowledge of caretakers and differences in health care and insurance systems play a role in the speech rehabilitation options that can be offered. or tracheoesophageal (TE) fistula. The voice prosthesis enables pulmonary air to enter the esophagus, and prevents esophageal content from entering the airway. In TES, pulmonary air is the driving force for the mucosal vibrations in the PE-segment. In ELS the substitute sound source is external: an Abstract Background Esophageal speech (ES), tracheoesophageal speech (TES) and/or electrolarynx speech (ELS) are three speech rehabilitation methods which are commonly provided after total laryngectomy (TL). Methods to evaluate comparative acoustic, and patient-reported outcomes for TES, and healthy speakers.
An Algorithm for Enumerating All Maximal Tree Patterns Without Duplication Using Succinct Data Structure

In order to extract structured features from big tree-structured data, a fast and memory-efficient tree mining algorithm is needed. In this paper, we propose an efficient algorithm, given a set S of ordered trees as input, to enumerate all maximal ordered tree patterns explaining all ordered trees in S without duplication. The enumeration algorithm uses a depth-first unary degree sequence (DFUDS), which is a succinct data structure for an ordered tree, as a succinct data structure for ordered tree patterns that express structured features of a tree structure. We also implement the proposed algorithm on a computer and evaluate the algorithm by experiments. The results are reported and discussed.
Estimating Slip Distribution for the İzmit Mainshock from Coseismic GPS, ERS-1, RADARSAT, and SPOT Measurements

We use four geodetic satellite systems (Global Positioning System (GPS), European Remote Sensing (ERS), RADARSAT, and Satellite Pour l'Observation de la Terre (SPOT)) to measure the permanent deformation field pro- duced by the I zmit earthquake of 17 August 1999. We emphasize measurements from interferometric analysis of synthetic aperture radar (SAR) images acquired by ERS and RADARSAT and their geodetic uncertainties. The primary seismological use of these data is to determine earthquake source parameters, such as the distri- bution of slip and the fault geometry. After accounting for one month's postseismic deformation, tropospheric delay, and orbital gradients, we use these data to estimate the distribution of slip at the time of the I zmit mainshock. The different data sets resolve different aspects of the distribution of slip at depth. Although these estimates agree to first order with those derived from surface faulting, teleseismic recordings, and strong motion, careful comparison reveals differences of 40% in seismic mo- ment. We assume smooth parameterization for the fault geometry and a standard elastic dislocation model. The root mean square residual scatter is 25 mm and 11 mm for the ERS and RADARSAT range changes, respectively. Our estimate of the moment from a joint inversion of the four geodetic data sets is M0 1.84 10 20 N m, a moment magnitude of M w 7.50. These values are lower than other estimates using more realistic layered earth models. Given the differences between the various models, we conclude that the real errors in the estimated slip distributions are at the level of 1 m. The prudent geophysical conclusion is that coseismic slip during the Izmit earthquake tapers gradually from approximately 2 m under the Hersek delta to 1 m at a point 10 km west of it. We infer that the Yalova segment west of the Hersek delta may remain capable of significant slip in a future earthquake.
Revisiting Olbers's Paradox in a Cellular Universe

Olbers’s paradox puts some constraints on the current cosmologies, i.e., the sky is not innitely bright. A way to solve the paradox is to distinguish between the number and the density of the galaxies. A careful analysis has been made of the number of galaxies as a function of distance using the 2MASS Redshift Survey (2MRS) catalog. The obtained results for the nite intensity of light are compared with the intensity of the extra-galactic background at 520 nm.
Pointwise estimates in the Filippov lemma and Filippov-Ważewski theorem for fourth order differential inclusions

In this work we give a generalization of the Filippov-Wazewski Theorem to the fourth order differential inclusions in a separable complex Banach space $\mathbb{X}$ \begin{equation*} \mathcal{D}y=y^{\prime \prime \prime \prime }-( A^{2}+B^{2}) y^{\prime \prime }+A^{2}B^{2}y\in F( t,y) , \end{equation*} with the initial conditions in $c\in \lbrack 0,T]$ \begin{equation} y( c) =\alpha ,\qquad y^{\prime }( c) =\beta ,\qquad y^{\prime \prime }( c) =\gamma ,\qquad y^{\prime \prime \prime }( c) =\delta , \label{*} \end{equation} We assume that the multifunction $F:\left[ 0,T\right] \times \mathbb{X}% \leadsto c( \mathbb{X}) $ is Lipschitz continuous in $y$ with the integrable Lipschitz constant $l( .) $, while $A^{2},B^{2}\in B( \mathbb{X}) $ are the infinitesimal generators of two cosine families of operators. The main result is the following version of Filippov Lemma: \medskip {\sc Theorem:} {\it Let $y_{0}\in W^{4,1}=W^{4,1}([ 0,T] ,\mathbb{X}) $ be such function with \rom{(\ref{*})} that \begin{equation*} \mathrm{dist}( \mathcal{D}y_{0}( t) ,F( t,y_{0}( t) ) ) \leq p_{0}( t) \quad \text{a.e. \ in } [ c,d] \subset [ 0,T] , \end{equation*}% where $p_{0}\in L^{1}[ 0,T] $. Then there are $\mathcal{\sigma }_{0}$ \rom{(}depending on $p_{0})$ and $\varphi $ such that for each $\varepsilon > 0$\ there exists a solution $y\in W^{4,1}$ of the above problem such that almost everywhere in $t\in \lbrack c,d]$ we have $\vert \mathcal{D}y( t) -\mathcal{D}y_{0}( t) \vert \leq \mathcal{\sigma }_{0}( t) $, \begin{alignat*}2 \vert y( t) -y_{0}( t) \vert &\leq(\varphi \ast _{c}\sigma _{0})( t) , &\qquad \vert y^{\prime }( t) -y_{0}^{\prime }( t) \vert \leq ( \varphi ^{\prime }\ast _{c}\sigma _{0}t) ( t ) , \\ \vert y^{\prime \prime }( t) -y_{0}^{\prime \prime }( t) \vert &\leq ( \varphi ^{\prime \prime }\ast _{c}\sigma _{0}) ( t) &\qquad \vert y^{\prime \prime \prime }( t) -y_{0}^{\prime \prime \prime }( t) \vert \leq( \varphi ^{\prime \prime \prime }\ast _{c}\sigma _{0})( t) , \end{alignat*}% where $\ast _{c}$ stands for the convolution started at $c$. } Our estimates are constructive and more precise then those in the known versions of Filippov Lemma.
Antidepressant and Anxiolytic Potentials of Dichloromethane Fraction from Hedranthera barteri

The dichloromethane fraction of Hedranthera barteri (DMHBR), a common medicinal plant, was investigated in animal models of depression and anxiety in mice. Graded doses (25-200mg/kg p.o. bw) of DMHBR reduced the immobility time with significant effects produced by 50mg/kg (43.7%), 100mg/kg (45.6%) and 200mg/kg (31.5%) in the tail suspension test (TST) and by 100mg/kg (66.3%) in forced swimming test (FST), indicating a possible antidepressant-like activity when compared with standard antidepressant drug, imipramine. Furthermore, a diminution in the anxiety response was also observed against elevated plus maze and light dark tests, which signify its anti-anxiety activity when compared with standard anxiolytic drug, diazepam. Moreover, DMHBR has no significant effects on both the motor coordination of the mice in the rota rod test and the sleeping time in the pentobarbitone-induced sleeping time test. These results show that DMHBR has significant neuropharmacological activity as an antidepressant and anxiolytic activity.
Hard-decoding vector quantization using Bayes estimator for Rayleigh channel

Vector quantization is decoded using a Bayes estimator. The hard-decision Bayes estimator is used to reduce the complexity involving the evaluation of transition probabilities for the soft-decision Bayes estimator. In the range of low to moderate average channel signal-to-noise ratio, the hard-decision Bayes estimator based source decoder can achieve more than 1 dB improvement over the conventional mapping based source decoder. With great reduction in complexity, the hard-decision Bayes estimator can achieve a performance that is just about 0.4 dB below the optimal soft-decision Bayes estimator.
Improvement in piezoelectric performance of a ZnO nanogenerator by modulating interface engineering of CuO-ZnO heterojunction

In this paper, we demonstrate an approach of enhancing the output performance of nanogenerators (NGs) by modulating interface engineering of ZnO-CuO nano-heterojunctions. By properly modulating the preparation technology sequence of ZnO-CuO PN junctions, excessive electrons in ZnO can be effectively suppressed. By utilizing this approach, we obtained an output current up to ∼1200 nA measured under the same compressive force of ∼1 kgf, which is a 25-fold higher output current compared with that of the NG based on pure ZnO NWs. The corresponding working mechanisms were also discussed in this paper by using an interface energy band theory. This work may provide a potential approach to boosting the piezoelectric performance of the NGs based on ZnO-CuO PN junctions.In this paper, we demonstrate an approach of enhancing the output performance of nanogenerators (NGs) by modulating interface engineering of ZnO-CuO nano-heterojunctions. By properly modulating the preparation technology sequence of ZnO-CuO PN junctions, excessive electrons in ZnO can be effectively suppressed. By utilizing this approach, we obtained an output current up to ∼1200 nA measured under the same compressive force of ∼1 kgf, which is a 25-fold higher output current compared with that of the NG based on pure ZnO NWs. The corresponding working mechanisms were also discussed in this paper by using an interface energy band theory. This work may provide a potential approach to boosting the piezoelectric performance of the NGs based on ZnO-CuO PN junctions.
AN INVESTIGATION OF THE MYOPIA FOR FUTURE CONSEQUENCES THEORY OF VMF PATIENT BEHAVIOUR ON THE IOWA GAMBLING TASK: AN ABSTRACT NEURAL NETWORK SIMULATION

Somatic marker theory proposes that body states act as a valence associated with potential choices based on prior outcomes; and thus aid decision-making. The main supporting evidence for this theory arose from clinical interviews of subjects with ventromedial prefrontal cortex (VMF) lesions and their performance on the Iowa Gambling Task (IGT). VMF patient behaviour has been described as myopia about future consequences. The aim of this paper is to investigate the implications of this description using an abstract simulation of the neural mechanisms that could underlie decision-making in this type of reinforcement learning task.
Paths to Successful Development: Personality in the Life Course

Personality and paths to successful development: an overview Lea Pulkkinen and Avshalom Caspi Part I. Temperament and Emotion Regulation: 1. Temperament and socialization Mary K. Rothbart and Samuel P. Putnam 2. The role of emotionality and regulation in children's social competence and adjustment Nancy Eisenberg, Richard A. Fabes, Ivanna K. Guthrie and Mark Reiser Part II. Formation of Social Relationships: 3. Attachment relationships and appraisal of partnership: from early experience of sensitive support to later relationship representation Klaus E. Grossmann, Karin Grossmann, Monika Winter and Peter Zimmermann 4. How do adolescents select their friends? a behaviour genetic perspective Richard J. Rose Part III. Continuity in Individual Life Paths: 5. Personality types in childhood and adolescence: main effects and person-relationship transactions Marcel A. G. van Aken, Cornelis F. M. van Lieshout, Ron H. J. Scholte and Gerbert J. T. Haselager 6. The influence of early behaviour patterns on later life Glen H. Elder, Jr. and Robert Crosnoe 7. Studying processes: some methodological considerations Lars Bergman Part IV. Environmental Contributions to Personality Development: 8. The role of ethnic identity in personality development Brett Laursen and Vicki Williams 9. Time and change: psychosocial transition in German adults 1991 and 1996 Rainer K. Silbereisen, Matthias Reitzle and Linda Juang Part V. Life Transitions: 10. Developmental regulation of life-course transitions: a control theory approach Jutta Heckhausen 11. Social selection, social causation, and developmental pathways: empirical strategies for better understanding how individuals and environments are linked across the life course Avshalom Caspi 12. Pathways through challenge: implications for well-being and health Carol D. Ryff, Burton H. Singer and Marsha Mailick Seltzer Part VI. Personal Goals and Well-Being: 13. Individual differences in personal goals in mid-thirties Lea Pulkkinen, Jari-Erik Nurmi and Katja Kokko 14. Social Production Function (SPF) theory as an heuristic for understanding developmental trajectories and outcomes Johan Ormel 15. Searching for paths to successful development and ageing: integrating developmental and action-theoretical perspectives Jochen Brandstadter.
LOW POWER 3-2 AND 4-2 ADDER COMPRESSORS IMPLEMENTED USING ASTRAN

This project introduces a set of graph-based algorithms for efficiently 3-2 and 4-2 Adder VLSI circuits using simple cells. The proposed algorithms are concerned to, first, effectively minimize the number of logic elements implementing the synthesized circuit. Then, we focus a significant effort on minimizing the number of inverters in between these logic elements. Finally, this logic representation is mapped into a circuit comprised of only two-input NANDs and NORS, along with the inverters. Two-input XORs and XNORs can also be optionally considered. As we also consider sequential circuits in this work, flip-flops are taken into account as well. Additionally, with high-effort optimization on the number of logic elements, the generated circuits may contain some cells with unfeasible fanout for current technology nodes. In order to fix these occurrences, we propose an area-oriented, level-aware algorithm for fanout limitation. The proposed algorithms were applied over a set of benchmark circuits and the obtained results have shown the usefulness of the method. We show that efficient implementations in terms of inverter count, transistor count, area, power and delay can be generated from circuits with a reduced number of both simple cells and inverters, combined with XOR/XNOR-based optimizations. The proposed buffering algorithm can handle all unfeasible fanout occurrences, while (i) optimizing the number of added inverters; and (ii) assigning cells to the inverter tree based on their level criticality. When comparing with academic and commercial approaches, we are able to simultaneously reduce the average number of inverters, transistors, area, power dissipation and delay up to 48%, 5%, 5%, 5%, and 53%, respectively. As the adoption of a limited set of simple standard cells have been showing benefits for a variety of modern VLSI circuits constraints, such as layout regularity, routability constraints, and/or ultra low power constraints, the proposed methods can be of special interest for these applications. Additionally, some More-than-Moore applications, such as printed electronics designs, can also take benefit from the proposed approach.