Miracle-dz/UniFAR-FTUs huggingface dataset:
Update 2016–2018 of the Nationwide Danish Fungaemia Surveillance Study: Epidemiologic Changes in a 15-Year Perspective

As part of a national surveillance programme initiated in 2004, fungal blood isolates from 2016–2018 underwent species identification and EUCAST susceptibility testing. The epidemiology was described and compared to data from previous years. In 2016–2018, 1454 unique isolates were included. The fungaemia rate was 8.13/100,000 inhabitants compared to 8.64, 9.03, and 8.38 in 2004–2007, 2008–2011, and 2012–2015, respectively. Half of the cases (52.8%) involved patients 60–79 years old and the incidence was highest in males ≥70 years old. Candida albicans accounted for 42.1% of all isolates and Candida glabrata for 32.1%. C. albicans was more frequent in males (p = 0.03) and C. glabrata in females (p = 0.03). During the four periods, the proportion of C. albicans decreased (p < 0.001), and C. glabrata increased (p < 0.001). Consequently, fluconazole susceptibility gradually decreased from 68.5% to 59.0% (p < 0.001). Acquired fluconazole resistance was found in 4.6% Candida isolates in 2016–2018. Acquired echinocandin resistance increased during the four periods 0.0%, 0.6%, 1.7% to 1.5% (p < 0.0001). Sixteen echinocandin-resistant isolates from 2016–2018 harboured well-known FKS resistance-mutations and one echinocandin-resistant C. albicans had an FKS mutation outside the hotspot (P1354P/S) of unknown importance. In C. glabrata specifically, echinocandin resistance was detected in 12/460 (2.6%) in 2016–2018 whereas multidrug-class resistance was rare (1/460 isolates (0.2%)). Since the increase in incidence during 2004–2011, the incidence has stabilised. In contrast, the species distribution has changed gradually over the 15 years, with increased C. glabrata at the expense of C. albicans. The consequent decreased fluconazole susceptibility and the emergence of acquired echinocandin resistance complicates the management of fungaemia and calls for antifungal drug development.
Human Impact Enables an Ecological Niche Shift for Invasive Widow Spiders

Background: Predicting invasiveness requires understanding the propensity of a given species to thrive in areas with novel ecological challenges. The Australian redback spider, Latrodectus hasselti, a widow spider native to Australia and established in Japan, New Zealand, and Southeast Asia. We hypothesized that human impact is important for successful establishment of this anthropophilic species, and that climate factors may determine suitable habitat and thus predict invasive ranges.Results: We used ecological niche models to predict the potential distributions of this invasive species and to infer variables most important for population persistence by relating species observations to climatic variables and measures of human impact. We found L. hasselti distributions are positively influenced by human impact, particularly in the native range. Native distributions were most strongly predicted by maximum temperature and invasive distributions by precipitation seasonality.Conclusions: A strong climatic niche shift was detected in invasive populations compared to the natives. We infer that a preference for human-disturbed environments may underlie invasion and establishment in this species.
Digital Computation of Fractional Fourier Transform

Based on the concept of the fractional fourier transform, its digital computation is given through computer simulation. In terms of linear frequency modulation (LFM) signal, the relation between fractional order and modulation slope is analyzed and the performance comparison with matched filter is given. Moreover, the separation of LFM signal and noise is realized in low signal-to-noise ratio through simulation. Simulation results indicate that the energy of LFM signal will be collected effectively when the fractional order is matching with its modulation slope. In weak signals detection of underwater acoustic domain, we can get high anti-Doppler performance using the Fractional fourier transform algorithm. 
Assembling neighbourhoods: topologies of power and the reshaping of planning

This chapter assesses two issues in relation to debates on power, which is central to neighbourhood planning. It argues that the dynamics and relations of power in neighbourhood planning are, in reality, more complex. As such, the chapter draws on notions of topologies of power, which suggest that it is the ‘social relationships, exchanges and interactions involved’, rather than spatial metrics, which are of significance in understanding the complexities of the contemporary shifts in governance of which neighbourhood planning is part. It also explores the ways in which such a perspective can enable an understanding of how ‘the neighbourhood’ is constructed through the dynamics of these assemblages of political actors, and the role of practices such as neighbourhood planning within this. The chapter begins by engaging with debates about the rescaling of governance, setting out the case for moving beyond existing topographical accounts to explore the topology of power. It then goes on to apply this lens to reveal the dynamics of the micro-politics of particular case studies and how a variety of ‘localisms’ are being assembled through the practices of neighbourhood planning.
The impact of organisation environment on effectiveness

The relationship between the organisation environment and its effectiveness was analysed using the data collected from six organisations. The study indicated that there were only three dimensions of the organisation environment out of eleven which had a significant role to play in determining its effectiveness. Interesting revelations regarding the difference in the two groups with regard to the dimensions which mattered to them were discovered. The effective group was more sensitive to the three dimensions of the organisation environment. Only one such dimension mattered to the not so effective group. Some dimensions influenced the organisation effectiveness more as compared to other dimensions.
Wearable Triboelectric Nanogenerator from Waste Materials for Autonomous Information Transmission via Morse Code

Electronic waste produced by plastic, toxic, and semiconducting components of existing electronic devices is dramatically increasing environmental pollution. To overcome these issues, the use of eco-friendly materials for designing such devices is attaining much attention. This current work presents a recycled material-based triboelectric nanogenerator (TENG) made of plastic waste and carbon-coated paper wipes (C@PWs), in which the PWs are also collected from a waste bin. The resultant C@PW-based TENG is then used for powering low-power electronic devices and, later, to generate a Morse code from a wearable for autonomous communication. In this application, the end users decode the Morse code from a customized LabVIEW program and read the transmitted signal. With further redesigning, a 9-segment keyboard is developed using nine-TENGs, connected to an Arduino controller to display the 9-segment actuation on a computer screen. Based on the above analysis, our C@PW-TENG device is expected to have an impact on future self-powered sensors and internet of things systems.
Abiotic stress cross-tolerance in eucalyptus grandis: does pre-exposure to chilling stress induce cross-tolerance to cryopreparative drying of in vitro shoots of E. grandis

Dissertation submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science. School of Animal, Plant and Environmental Sciences, University of the Witwatersrand, Johannesburg, South Africa
Relações entre Crimes e o Espaço Urbano: Um Estudo de Caso Baseado em Pontos de Interesses Extraídos da Web

Altos índices de criminalidade estão dentre os principais problemas que afetam negativamente a qualidade de vida nos centros urbanos. No Brasil, em particular, estima-se uma taxa média de 20 mortes por mês para cada 100 mil habitantes em decorrência de situações de violência. As altas taxas de criminalidade nas cidades brasileiras poderiam ser melhor analisadas e compreendidas a partir de fontes de dados alternativas que exploram características do espaço urbano. Neste artigo, investigamos a relação entre índices de criminalidade e essas características reﬂetidas em pontos de interesse (POIs) que as pessoas registraram em um serviço Web para a cidade de São Paulo. Mostramos o potencial desse tipo de dado para predizer índices de crimes por regiões da cidade. Nesse sentido, construímos modelos de regressão com desempenhos satisfatórios para essa predição e exploramos esses modelos para descobrir as categorias de POIs mais importantes para explicar os crimes mais frequentes por regiões das cidades. Adicionalmente, analisamos o ganho de desempenho com o aumento de POIs registrados na cidade ao longo dos anos.
Direct Pattern Growth of Carbon Nanomaterials by Laser Scribing on Spin-Coated Cu-PI Composite Films and Their Gas Sensor Application

The excellent physical and chemical properties of carbon nanomaterials render them suitable for application in gas sensors. However, the synthesis of carbon nanomaterials using high-temperature furnaces is time consuming and expensive. In this study, we synthesize a carbon nanomaterial using local laser-scribing on a substrate coated with a Cu-embedded polyimide (PI) thin film to reduce the processing time and cost. Spin coating using a Cu-embedded PI solution is performed to deposit a Cu-embedded PI thin film (Cu@PI) on a quartz substrate, followed by the application of a pulsed laser for carbonization. In contrast to a pristine PI solution-based PI thin film, the laser absorption of the Cu-embedded PI thin film based on Cu@PI improved. The laser-scribed carbon nanomaterial synthesized using Cu@PI exhibits a three-dimensional structure that facilitates gas molecule absorption, and when it is exposed to NO2 and NH3, its electrical resistance changes by −0.79% and +0.33%, respectively.
Simulation of the dynamics of vibrationally mediated photodissociation for deuterated pyrrole

The dynamics of photodissociation for vibrationally pre-excited deuterated pyrrole molecules is simulated using ab initio multiple cloning (AIMC) approach. Total kinetic energy release (TKER) spectra and dissociation times are calculated. The results for pyrrole and deuterated pyrrole molecules with and without vibrational pre-excitation are compared. Calculations show that, as expected, the kinetic energy of additional dissociation fragments is lower in deuterated pyrrole and mostly located in the upper-middle part of the TKER spectrum. However, despite lower energy of dissociative bond vibrations, pre-excitation of deuterated pyrrole leads to higher dissociation yield increase than in pyrrole and significantly shortens dissociation time.
Choice of robot creation material

Along with progress unremittingly of science and technology and the calculator technical fast development, the robot technique is more and more subjected to people's widespread concern, and got in numerous realms extensively applied.The quality which creates robot material a choice will directly influence robot of just machine functions such as degree and strength etc.Therefore, principle and method of the this research's material choice toward each realm robot creation make to elaborate, for resolve the material in the robot creation of excellent turn an allocation problem to have to certainly draw lessons from a function.
Potential Application of an Aqueous Extract of Tinospora Cordifolia (Thunb.) Miers (Giloy) in Oral Submucous Fibrosis—An In Vitro Study

The in vitro antifibrotic activity of Tinospora cordifolia (Thunb.) Miers (giloy) was assessed to explore its potential for the management of oral submucous fibrosis. Epithelial cells dissociated from the tissue obtained from histopathologically normal oral mucosa during surgical extraction of third molars were cultured and fibrosis was induced by TGF-β1 in the oral keratinocytes. Cell viability was assessed by MTT and comparative gene expression analysis was carried out in the fibrosis-induced oral keratinocytes treated with various concentrations of Tinospora cordifolia extract (TcE) for matricellular protein-related gene expression. Concentrations of 0.5 µg/mL and 1 µg/mL TcE demonstrated a significant reduction in the expression of CTGF, SERPINE1, COL1A1, FN1, MMP1, MMP2, MMP3, and TIMP2 and an increase in the expression of PLAU, COL3A1, TIMP1, and TIMP3. Although TcE was found to reduce the expression of several fibrotic genes and increase the expression of antifibrotic genes, a varied effect was found, causing increased expression of COL3A1 and decreased expression of TIMP2 on TGF-β1-induced human buccal epithelial cells. However, further studies are warranted to assess the exact mechanism of antifibrotic activity and its clinical applications.
Designing and Evaluating a Professional Sound Reinforcement System for Adults

The purpose of this instructional design project was to develop and evaluate an instructional module to improve basic knowledge of signal path and how to create an audio sound system for adult clients at Creative Sound and Lighting. The best way to reach as many potential customers and audio enthusiasts as possible, was to develop an online module with multimedia.
Caracterização do Impacto de Incidentes de Aplicações em Redes e Usuários

Estudos focados na caracterização de incidentes com impacto na rede são primordiais para a melhoria da experiência do usuário, principalmente diante de redes com complexidade crescente e do surgimento de novas tecnologias cada vez mais dependentes de Internet. As causas destes incidentes são diversas, podendo ser manutenções programadas, falhas de roteamento, rompimento de cabos ópticos ou falhas de configuração em dispositivos como roteadores e comutadores. Em nosso estudo buscamos aumentar a nossa compreensão analisando de diferentes perspectivas o impacto de incidentes ocorridos em grandes provedores de conteúdo. Caracterizamos o impacto de incidentes no comportamento de usuários e aplicações. Nossos resultados apontam para mudanças no perfil de tráfego durante incidentes em aplicações, como o aumento do número de ﬂuxos acompanhado de redução do volume de tráfego, e mudanças no comportamento de usuários, incluindo a migração de demanda de aplicações afetadas pelo incidente para outras não afetadas.
Developing a Glyoxal-Crosslinked Chitosan/Gelatin Hydrogel for Sustained Release of Human Platelet Lysate to Promote Tissue Regeneration

The clinical application of human platelet lysate (HPL) holds promise for tissue regeneration, and the development of an efficient vehicle for its delivery is desired. Chitosan-based hydrogels are potential candidates, but they often exhibit weak mechanical properties. In this study, a chitosan/gelatin (CS-GE) hydrogel crosslinked by glyoxal was fabricated for sustained release of HPL. The influence of HPL on Hs68 fibroblast and human umbilical vein endothelial cell (HUVEC) culture was evaluated, and we found that supplementing 5% HPL in the medium could significantly improve cell proliferation relative to supplementing 10% fetal bovine serum (FBS). Moreover, HPL accelerated the in vitro wound closure of Hs68 cells and facilitated the tube formation of HUVECs. Subsequently, we fabricated CS-GE hydrogels crosslinked with different concentrations of glyoxal, and the release pattern of FITC-dextrans (4, 40 and 500 kDa) from the hydrogels was assessed. After an ideal glyoxal concentration was determined, we further characterized the crosslinked CS-GE hydrogels encapsulated with different amounts of HPL. The HPL-incorporated hydrogel was shown to significantly promote the proliferation of Hs68 cells and the migration of HUVECs. Moreover, the release pattern of transforming growth factor-β1 (TGF-β1) and platelet-derived growth factor-BB (PDGF-BB) from hydrogel was examined in vitro, demonstrating a sustained release profile of the growth factors. Finally, the chick chorioallantoic membrane assay revealed that HPL encapsulation in the hydrogel significantly stimulated angiogenesis in ovo. These results demonstrate the great potential of the crosslinked CS-GE hydrogel to serve as an effective delivery system for HPL to promote tissue regeneration.
Cellular senescence: all roads lead to mitochondria

Senescence is a multi‐functional cell fate, characterized by an irreversible cell‐cycle arrest and a pro‐inflammatory phenotype, commonly known as the senescence‐associated secretory phenotype (SASP). Emerging evidence indicates that accumulation of senescent cells in multiple tissues drives tissue dysfunction and several age‐related conditions. This has spurred the academic community and industry to identify new therapeutic interventions targeting this process. Mitochondrial dysfunction is an often‐unappreciated hallmark of cellular senescence which plays important roles not only in the senescence growth arrest but also in the development of the SASP and resistance to cell‐death. Here, we review the evidence that supports a role for mitochondria in the development of senescence and describe the underlying mechanisms. Finally, we propose that a detailed road map of mitochondrial biology in senescence will be crucial to guide the future development of senotherapies.
Erfolg bei Crowdfunding-Kampagnen: Eine Perspektive aus E-Commerce und Social Media (Crowdfunding Success: A Perspective from Social Media and E-Commerce)

German Abstract: Mit Crowdfunding hat sich in den letzten Jahren eine neue Finanzierungsform etabliert. Bislang ist jedoch nur wenig daruber bekannt, wie Projektinitiatoren die Erfolgschancen in ihren Crowdfunding-Kampagnen steigern konnen, indem sie sog. „On-Page“ (auf der Projektseite) und „Off-Page“ Kommunikationsmass-nahmen (ausserhalb der Projektseite) einsetzen. Im vorliegenden Beitrag untersuchen wir bei 740 Crowdfunding-Kampagnen der Schweizer Plattform 100-days.net, inwieweit sich derartige kommunikationsbezogene Massnahmen der Projektinitiatoren auf ver-schiedene Erfolgsmasse der Kampagnen auswirken. Dabei analysieren wir mogliche Effekte auf: (1) die Anzahl der Zahlungen, (2) die durchschnittliche Hohe der Zahlungen und (3) den letztendlichen Kampagnenerfolg. Unsere Ergebnisse zeigen, dass die Nutzung reichhaltiger Medien und zahlreiche Projekt-Updates die Erfolgschancen steigern. Im Gegensatz dazu zeigen sich keine Effekte aufgrund der einfachen Einbindung von Social Media Kanalen in Crowdfunding-Kampagnen.English Abstract: Crowdfunding as a new way of financing in the web 2.0 has increased over the last years, but only little is known how project initiators increase their chances of successful fundraising through on-page and off-page communication activities. Using a dataset of 740 projects published on one of the dominant crowdfunding platforms in Switzerland, we test communication-related determinants of fundraising success in terms of (1) number of donations (2) average amount of donations and (3) total campaign success. Our results show that high media richness in the project presentation and a high frequency of project updates leverage fundraising success. In contrast, no beneficial effects of the mere application of social media channels could be observed. The implications for research on crowdfunding and practice are discussed.
Verifying Computation Tree Logic of Knowledge via Knowledge-Oriented Petri Nets and Ordered Binary Decision Diagrams

Computation Tree Logic of Knowledge (CTLK) can specify many requirements of privacy and security of multi-agent systems (MAS). In our previous papers, we defined Knowledge-oriented Petri Net (KPN) to model MAS, proposed similar reachability graph to verify CTLK, gave their model checking algorithms and developed a related tool. In this paper, we use the technique of Ordered Binary Decision Diagrams (OBDD) to encode similar reachability graph in order to alleviate the state explosion problem, and verify more epistemic operators of CTLK. We design the corresponding symbolic model checking algorithms and improve our tool. We compare our model and method with MCMAS that is the state-of-the-art CTLK model checker, and experiments illustrate the advantages of our model and method. We also explain the reasons why our model and method can obtain better performances.
Association between Thyroid Cancer and Breast Cancer: Two Longitudinal Follow-Up Studies Using a National Health Screening Cohort

Abstract Background: The purpose of this study was to evaluate the association between thyroid cancer and breast cancer. Methods: Data from the Korean National Health Insurance Service-Health Screening Cohort were collected from 2002 to 2013. In study I, 3949 thyroid cancer participants were 1:4 matched with 15,796 control I participants, and hazard ratios (HRs) with 95% confidence intervals (CIs) for breast cancer were evaluated using a stratified Cox proportional hazard model. In study II, 3308 breast cancer participants were 1:4 matched with 13,232 control II participants, and HRs with 95% CIs for thyroid cancer were assessed in the same way as in study I. In the subgroup analyses, associations were analyzed according to radioactive iodine (RAI) treatment and age (<60 years old and ≥60 years old). Results: The adjusted HR for breast cancer in the thyroid cancer group was 1.64 (95% CI = 1.13–2.39, p = 0.010). The adjusted HR for thyroid cancer in the breast cancer group was 1.91 (95% CI = 1.47–2.49, p < 0.001). In the subgroup analyses, the groups that were older and not treated with RAI treatment showed consistent results in study I, and the younger and older groups showed consistent results in study II. Conclusions: Based on this cohort study, breast and thyroid cancer have a reciprocal positive association.