Miracle-dz/UniFAR-FTUs huggingface dataset:
EVALUATION OF FACTORS INFLUENCING TOTAL QUALITY MANAGEMENT IMPLEMENTATION IN RWADAN CONSTRUCTION COMPANIES: CASE OF FAIR CONSTRUCTION COMPANY

he role of construction quality and continuous improvement is vital in the development of construction industry of growing nations. Construction quality and regular improvement is linked with the adoption of quality management systems in construction companies. It is therefore important that adequate measures are put in place to ensure quality in the sector. Total Quality Management (TQM) is considered as one of the most important approaches to achieve quality in construction Industry not only in Rwanda but the world over. This study sought to determine the factors influencing implementation of TQM in construction companies in Rwanda. Kigali province was used as a case for the study. The literature for this study was reviewed basing on the following factors; Top management commitment, Employees’ training, organization culture and communication. The study adopted a descriptive research design. Stratified random sampling was used to determine the sample size. Primary data for the study was collected using structured questionnaires that were administered to the respondents. A Cronbach alpha coefficient was computed using SPSS and generated the value of 0.843. Comparing this value with the threshold of 0.7 ensured reliability of the questionnaire. Data collected will be analyzed through SPSS version 21. The study revealed that Top Management Commitment, Employee’s Training, organizational culture and Communication are critical factors in implementation of TQM in Construction Companies in Rwanda. The study recommends that construction companies as well as other organizations who are implementing TQM take strategic measures in ensuring top management participation and commitment to quality initiatives.
Performance Evaluation for PUF-based Authentication Systems with Shift Post-processing : Additional Experimental Results

A physical unclonable function (PUF) is a physical system with a device manufacturing variations and could be useful for authentication of integrated circuits. However, it is claimed that the amount of randomness in the PUF output is limited. Therefore, the response of the PUF cannot be used directly as a key. In this paper we discuss a making method of the PUF output with much more randomness while maintaining the reliability. In order to do this, a simple shift post-processing will apply to the Arbiter and Ring Oscillator PUF output. The experimental results show that the authentication system using shifted response data have improved performance compared to non-shifted data.
The influence of the cutting attachment on vibrations emitted by brush cutters and grass trimmers

Abstract Generally, the choice of cutting attachment used in brush cutters for brushwoods and grasses depends on the type of work, on one hand, and the size of the engine, on the other. However, at the same time, the use of individually chosen cutting elements entails a certain risk of vibration resulting from their varying design and size, which has a big impact on comfort and working time, but most importantly on operator health. The aim of the study is a preliminary analysis of the dangers due to vibration of brush cutters and to determine how the choice of the cutting attachment affects the intensity of the vibrations emitted by the machine. Furthermore, one aim was to determine the daily vibration exposure, relative to an equivalent value of vibration, experienced by the device operator. This study involved four models of brush cutters with three machines of each model, differing in size (displacement and engine power) and equipped with six different cutting elements. A vibration acceleration test was carried out in accordance with the applicable PN-EN ISO 5349-1 and 2: 2004 and Directive 2002/44 / EC. An analysis of the obtained results leads to the conclusion that the examined professional brush cutters emit vibrations of such intensity that the daily exposure limit (5 m s−2) is exceeded more than two-fold. One cannot directly determine the influence on vibration intensity by the type of cutting attachment or the exhaust, but it should be noted that use of a cutting unit as recommended by the manufacturer creates less harmful vibrations, especially when the engine runs at the nominal rotational speed. In order to minimise the risk due to vibrations from brush cutters, engines with a cylinder capacity below 45 cm3 are recommended to be equipped with trimmer heads and disk knives, while engines with over 50 cm3 should run with circular saws.
Female rats are less prone to clinical heart failure than male rats in a juvenile rat model of right ventricular pressure load.

Sex is increasingly emerging as determinant of right ventricular (RV) adaptation to abnormal loading conditions. It is unknown, however, whether sex-related differences already occur in childhood. Therefore, this study aimed to assess sex differences in a juvenile model of early RV pressure load by pulmonary artery banding (PAB) during transition from pre- to post-puberty. 3-weeks old rat pups (n=57, 30-45g) were subjected to PAB or sham surgery. Animals were sacrificed either before or after puberty (4 and 8 weeks post-surgery, respectively). Male PAB rats demonstrated failure to thrive already after 4 weeks, whereas females did not. After 8 weeks, female PAB rats showed less clinical symptoms of RV failure than male PAB rats. RV pressure-volume analysis demonstrated increased end-systolic elastance after 4 weeks in females only, and a trend toward preserved end-diastolic elastance in female PAB rats compared to males (p=0.055). Histology showed significantly less RV myocardial fibrosis in female compared to male PAB rats 8 weeks after surgery. Myosin heavy chain 7/6 ratio switch and calcineurin signaling were less pronounced in female PAB rats, compared to males. In this juvenile rat model of RV pressure load, female rats appeared to be less prone to clinical heart failure, compared to males. This was driven by increased RV contractility before puberty, and better preservation of diastolic function with less RV myocardial fibrosis after puberty. These findings show that RV adaptation to increased loading differs between sexes already before the introduction of pubertal hormones.
Spontaneously Recycling Synaptic Vesicles Constitute Readily Releasable Vesicles in Intact Neuromuscular Synapses

Emerging evidence shows that spontaneous synaptic transmission plays crucial roles on neuronal functions through presynaptic molecular mechanisms distinct from that of action potential (AP)-evoked transmission. However, whether the synaptic vesicle (SV) population undergoing the two forms of transmission is segregated remains controversial due in part to the conflicting results observed in cultured neurons. Here we address this issue in intact neuromuscular synapses using transgenic zebrafish larvae expressing two different indicators targeted in the SVs: a pH-sensitive fluorescent protein, pHluorin, and a tag protein, HaloTag. By establishing a quantitative measure of recycled SV fractions, we found that ∼85% of SVs were mobilized by high-frequency AP firings. In contrast, spontaneously recycling SVs were mobilized only from <8% of SVs with a time constant of 45 min at 25°C, although prolonged AP inhibition mobilized an additional population with a delayed onset. The mobilization of the early-onset population was less temperature-sensitive and resistant to tetanus toxin, whereas that of the late-onset population was more sensitive to temperature and was inhibited by tetanus toxin, indicating that prolonged AP inhibition activated a distinct molecular machinery for spontaneous SV fusion. Therefore, the early-onset population limited to <8% was likely the only source of spontaneous release that occurred physiologically. We further showed that this limited population was independent from those reluctant to fuse during AP firing and was used in both the hypertonic stimulation and the immediate phase of AP-evoked releases, thereby matching the characteristics of the readily releasable pool. SIGNIFICANCE STATEMENT Synaptic vesicles (SVs) are divided into functionally distinct pools depending on how they respond to action potential (AP) firing. The origin of SVs used for spontaneous fusion remains enigmatic despite intensive studies in cultured preparations. We addressed this question in intact neuromuscular synapses and provided two findings. First, prolonged AP inhibition activated a distinct population of fusion, which needs to be distinguished from genuine spontaneous fusion arising from a highly limited fraction. Second, the limited fraction observed early in the AP inhibition period exhibited the characteristics of readily releasable pool in the subsequent round of stimulation. Our study revealed that the origin of spontaneous SV fusion is restricted to the readily releasable pool among the SV pools involved in AP-evoked fusion.
Smartphone Addiction Prevalence and Its Association on Academic Performance, Physical Health, and Mental Well-Being among University Students in Umm Al-Qura University (UQU), Saudi Arabia

Smartphone use can lead to smartphone addiction, which is a growing concern worldwide. However, there are limited studies about smartphone addiction and its impacts on university students in Saudi Arabia. This study aims to fill this gap. This is a quantitative study conducted among undergraduate students in Umm Al-Qura University (UQU), Saudi Arabia from May 2019 and February 2021. Study data were collected using both online and hard copy administered surveys. A self-administered questionnaire, Grade point average, Smartphone Addiction Short Version, and Kessler Psychological Distress scales were used to assess the outcomes. A total of 545 undergraduate students, mostly females, aged ≤21 years old and lived with large family sizes. More than half owned a smartphone for 5–8 years and the majority used their smartphone on average 6–11 h per day for social networking (82.6%), entertainment (66.2%) and web surfing (59.6%). Most of the participants were smartphone-addicted (67.0%). Logistic regression analysis showed that age ≤ 21, not gainfully employed, small family size and high family income were the main significant socio-demographic predictors of smartphone addiction. Smartphone-addicted participants were more likely to: have lower academic performance (GPA); be physically inactive; have poor sleep; be overweight/obese; have pain in their shoulder (39.2%), eyes (62.2%) and neck (67.7%) and have a serious mental illness (30.7%). This finding has significant implications for decision makers and suggests that smartphone education focusing on the physical and mental health consequences of smartphone addiction among university students can be beneficial.
Baicalein inhibits cell proliferation and enhances apoptosis in human A549 cells and benzo(a)pyrene‐induced pulmonary carcinogenesis in mice

Our current study is done to explore the possible mechanisms to elaborate on the growth inhibitory effect of baicalein (BE) in human lung carcinoma. Initially, BE (25 and 50 µM) treatment for 24 h, suppressed the viability and inhibited population growth in A549 cells. BE upholds the production of reactive oxygen species (ROS) with concomitant replenishment of glutathione, catalase, and glutathione peroxidase activity. The expression level of nuclear factor erythroid 2‐related factor 2 and heme oxygenase‐1 markedly increased after BE treatment will intimidate A549 cells proliferation by the ROS‐independent pathway via the antioxidant pathway. In vivo investigations were carried out on BE (12 mg/kg, oral) in benzo(a)pyrene (B(a)P; 50 mg/kg, oral) induced lung carcinogenesis in mice. BE induces caspase‐dependent apoptosis by increasing the levels of cytosolic cytochrome c accompanied by upregulating the outflow of p53, Bax, and caspase‐3 with a concomitant abatement in the outflow of Bcl‐2 in both in vitro and in vivo. In the murine model, BE treatment hindered the countenance of proliferation‐related proteins (argyrophilic nucleolar organizing regions and proliferating cell nuclear antigen). Additionally, appraisal of the cell nucleus by transmission electron microscopic assessment uncovered that BE treatment adequately counteracts B(a)P‐induced lung cancer cell survival. During the transition of the G0/G1 phase, BE is arrested in the cell cycle process. This might be the cause of a substantial increase in the appearance of p21Cip1 with concomitant downregulating the expressions of CDK4, cyclin D, and cyclin E both in vitro and in vivo. Our results conclude that BE treatment induced apoptosis and repressed proliferation both in vitro and in vivo of human lung carcinoma.
The Expression of Active CD11b Monocytes in Blood and Disease Progression in Amyotrophic Lateral Sclerosis

Monocytes expressing the inflammation suppressing active CD11b, a beta2 integrin, may regulate neuroinflammation and modify clinical outcomes in amyotrophic lateral sclerosis (ALS). In this single site, retrospective study, peripheral blood mononuclear cells from 38 individuals living with ALS and 20 non-neurological controls (NNC) were investigated using flow cytometry to study active CD11b integrin classical (CM), intermediate (IM) and non-classical (NCM) monocytes during ALS progression. Seventeen ALS participants were sampled at the baseline (V1) and at two additional time points (V2 and V3) for longitudinal analysis. Active CD11b+ CM frequencies increased steeply between the baseline and V3 (ANOVA repeated measurement, p < 0.001), and the V2/V1 ratio negatively correlated with the disease progression rate, similar to higher frequencies of active CD11b+ NCM at the baseline (R = −0.6567; p = 0.0031 and R = 0.3862; p = 0.0168, respectively). CD11b NCM, clinical covariates and neurofilament light-chain plasma concentration at the baseline predicted shorter survival in a multivariable and univariate analysis (CD11b NCM—HR: 1.05, CI: 1.01–1.11, p = 0.013. Log rank: above median: 43 months and below median: 21.22 months; p = 0.0022). Blood samples with the highest frequencies of active CD11b+ IM and NCM contained the lowest concentrations of soluble CD11b. Our preliminary data suggest that the levels of active CD11b+ monocytes and NCM in the blood predict different clinical outcomes in ALS.
Pistachio allergens: the long journey between mother and daughter.

Allergy Department. Niño Jesús University Children's Hospital. FIB Niño Jesús. IIS La Princesa. Madrid, Spain. Allergy Department. IIS-Fundación Jiménez Díaz. Madrid, Spain. Biochemistry and Molecular Biology Department. Universidad Complutense de Madrid, Spain. Foundation for biomedical research and innovation in Hospital Universitario Infanta Leonor, Madrid, Spain RETIC ARADyAL, Instituto de Salud Carlos III.
Correlation between Salivary Levels of IGF-1, IGFBP-3, IGF-1/IGFBP3 Ratio with Skeletal Maturity Using Hand-Wrist Radiographs

Objective: The relevance of growth determination in orthodontics is driving the search for the most precise and least invasive way of tracking the pubertal growth spurt. Our aim was to explore whether minimally invasive salivary estimation of biomarkers Insulin-like growth factor (IGF-1) and Insulin-like growth factor binding protein-3 (IGFBP-3) could be used to estimate skeletal maturity for clinical convenience, especially in children and adolescent age groups. Materials and Method: The cross-sectional study was conducted on 90 participants (56 girls and 34 males) with ages ranging from 6 to 25 years. Each subject’s hand-wrist radiograph was categorized based on skeletal maturity, and saliva samples were estimated for IGF-1 and IGFBP-3 using the respective ELISA kits. Kruskal–Wallis nonparametric ANOVA was applied to compare different skeletal stages. Results: The study demonstrated low salivary IGF-1 levels at the prepubertal stage, with increase during pubertal onset and peak pubertal stage followed by a decline during pubertal deceleration to growth completion. Spearman’s correlation coefficient demonstrated a strong positive association (r = 0.98 p < 0.01) between salivary IGF/IGFBP-3 ratio and different stages of skeletal maturity. Conclusion: Salivary IGF-1, IGFBP-3, and IGF/IGFBP-3 ratio could serve as a potential biochemical marker for predicting the completion of skeletal maturity.
Social stigma of suicide in South Korea: A cultural perspective

Abstract This study examined suicide stigma in relation to Korean cultural characteristics, such as Collectivism, Chemyon sensitivity (concern about losing a socially acceptable face), the tendency toward conformity, and the emphasis on the interdependent self. We found that these characteristics were connected to suicide stigma in Korea. Those with high Chemyon sensitivity tended to perceive that suicidal people were incompetent, immoral, selfish, and deviated from society. Conformity tendency was positively associated with five stigma factors: incompetence, glorification, immorality, selfishness, and social exclusion. Those who perceived themselves as interdependent tended to consider suicidal people incompetent, lacking morality, self-centered, and deviant.
Copper-Mediated β-Amyloid Toxicity and its Chelation Therapy in Alzheimer's Disease.

The link between bio-metals, Alzheimer's disease (AD), and its associated protein, amyloid-β (Aβ) is very complex and one of the most studied aspects currently. Alzheimer's disease, a progressive neurodegenerative disease, is proposed to occurs due to the misfolding and aggregation of Aβ. Dyshomeostasis of metal ions and their interaction with Aβ has largely been implicated in AD. Copper plays a crucial role in amyloid-β toxicity and AD development potentially occurs through direct interaction with the copper-binding motif of APP and different amino acid residues of Aβ. Previous reports suggest that high levels of copper accumulation in the AD brain result in modulation of toxic Aβ peptide levels, implicating the role of copper in the pathophysiology of AD. In this review, we explore the possible mode of copper ion interaction with Aβ which accelerates the kinetics of fibril formation and promote amyloid-β mediated cell toxicity in Alzheimer's disease and the potential use of various copper chelators in the prevention of copper-mediated Aβ toxicity.
The effects of gender and country of origin on acculturation, psychological factors, lifestyle factors, and diabetes-related physiological outcomes among Mexican Americans: The Starr County diabetes prevention initiative

Objectives Examine acculturation and psychological, lifestyle, and physiological factors based on gender and country of origin (U.S. vs. Mexico). Methods Baseline data from the Starr County diabetes prevention study (N = 300) were analyzed – acculturation (language), psychological factors (depression), lifestyle factors (sedentary behaviors), and diabetes-related physiological outcomes (insulin resistance). MANOVA and linear regression were used to examine variable relationships based on gender and country of origin and identify predictors of depression and insulin resistance. Results Participants were: predominantly female (73%); 51 years of age, on average; born in Mexico (71%); and Spanish-speaking. Individuals spent 11 of their waking hours (range = 0–18 h) in sedentary activities. Compared to females, more males spoke English and reported fewer hours in sedentary activities. Compared to participants born in Mexico, those born in the U.S. were more likely to: speak English; report depressive symptoms; and exhibit elevated BMI and insulin resistance rates. Two distinct models significantly predicted depression (R2 = 14.5%) and insulin resistance (R2 = 26.8%), with acculturation-language entering into both models. Discussion Significant gender and country-of-origin differences were found. Future research on diabetes prevention should examine other Hispanic subgroups and strategies for addressing individual differences, while employing cost-effective group interventions that incorporate these differences and reach more at-risk individuals.
Two-Stage Intelligent Multi-Type Artifact Removal for Single-Channel EEG Settings: A GRU Autoencoder Based Approach

Objective: The wearable and portable Electroencephalogram (EEG) sensing systems are deeply interfered by unavoidable physiological artifacts due to the limited recording resources. In this work, an intelligent artifact removal system that handles single-channel EEG signals in the presence of mixed multi-type artifacts is investigated. Methods: The basic idea is to represent the mixed artifacts in contaminated varying EEG signals with the unchanged latent pattern features, and then employ the adaptive artifact removal scheme to separate the contamination and clean EEG signals in the encoded feature domain. To minimize the risks of corrupting clean signals and keeping artifacts by mistake, the artifact removal is formulated as an identification-removal two-stage minimization problem, and an attention based adaptive feature concentration mechanism is designed to improve the removal utility and reduce the calculation consumption. Results: In the real implementation on open real-world dataset, this study achieves the artifact identification accuracy of 98.52% and average correlation coefficient of 0.73 for the removal of strong mixed multi-type artifacts. Conclusion: This study can deal with single-channel EEG signals contaminated by mixed multi-type artifacts with high accuracy and low overhead, and is more effective and stable than traditional schemes with fixed criteria. Significance: This study can significantly improve the signal quality acquired by simplified EEG sensing systems, and may extend the application of wearable and portable EEG sensing systems to medical diagnosis, cognitive science research and other applications requiring clinical setups.
Distress, depression, anxiety, and resilience in patients with cancer and caregivers.

OBJECTIVE Resilience is the ability to cope and function despite adversity, such as a cancer diagnosis, and has been conceptualized as the other end of a distress-resilience continuum. There are known associations among resilience, distress, depression, and anxiety-yet the nature of the associations is not well characterized. Less is known about the relationship among these variables for caregivers. We examined these associations in a convenience sample from a clinical setting with these hypotheses: (a) patients and nondyadic caregivers will report elevated, comparable levels of distress, depression, and anxiety, and (b) resilience will moderate the effect of distress on depression and anxiety. METHOD Participants were patients with a cancer diagnosis (n = 328) and nondyadic caregivers (n = 169). Participants completed a demographic/clinical questionnaire and self-report measures (National Comprehensive Cancer Network Distress Thermometer, Patient-Reported Outcomes Measurement Information System anxiety and depression measures, and Brief Resilience Scale). The statistical plan for this cross-sectional study included moderation analyses and various tests of association. RESULTS Patients and caregivers reported comparable levels of resilience and elevated distress; patients exhibited more severe depression and anxiety. There was no evidence for a moderating effect of resilience. For both groups, the model of distress predicting depression/anxiety exhibited improved fit when including resilience. Distress and resilience share variance in the prediction of depression/anxiety among patients. CONCLUSIONS Distress, depression, and anxiety are common in patients with cancer but also in cancer caregivers. Resilience appears to be an important variable to consider alongside distress and may enhance our understanding of the relationships among distress and depression/anxiety, especially for individuals with cancer. (PsycInfo Database Record (c) 2022 APA, all rights reserved).