Miracle-dz/UniFAR-FTUs huggingface dataset:
Diet dominates age in shaping the rumen bacteria community and function in dairy cattle

Background To understand the effects of diet and age on the rumen bacterial community and function, forty-eight dairy cattle at 1.5 (M1.5), 6 (M6), 9 (M9), 18 (M18), 23 (M23), and 27 (M27) months old were selected. The M1.5, M6, and M27 had the high protein and starch dietary, while the M9, M18, and M23 had the high fiber dietary. Fermentation profile, enzyme activity, and bacteria community in rumen fluid were measured. Results The acetate to propionate ratio (A/P) at M9, M18, and M23 (high fiber diet) was higher than other ages, and M6 was the lowest (P < 0.05). The total volatile fatty acid (TVFA) at M23 and M27 was higher than other ages (P < 0.05). The urease at M18 was lower than M1.5, M6, and M9, and the xylanase at M18 was higher than M1.5, M23, and M27 (P < 0.05). The α-diversity indexes (Ace and Chao1) of ruminal bacteria increased from M1.5 to M23, while they decreased from M23 to M27 (P < 0.05). Thirty-three bacteria were identified as biomarkers of the different groups based on the linear discriminant analysis (LDA) when the LDA score > 4. The variation partitioning approach analysis showed that the age and diet had a 7.98% and 32.49% contribution to the rumen bacteria community variation, respectively. The richness of Succinivibrionaceae_UCG-002 and Fibrobacter were positive correlated with age (r > 0.60, P < 0.01) and also positively correlated with TVFA and acetate (r > 0.50, P < 0.01). The Lachnospiraceae_AC2044_group, Pseudobutyrivibrio, and Saccharofermentans has a positive correlation (r > 0.80, P < 0.05) with diet NDF and negative correlation (r < -0.80, P < 0.05) with diet CP and starch, which were also positively correlated with the acetate and A/P (r > 0.50, P < 0.01). Conclusion These findings indicated that the quantitative effect of diet and age on the rumen bacteria were 7.98% and 32.49%, respectively. The genera of Lachnospiraceae_AC2044_group, Pseudobutyrivibrio, and Saccharofermentans could be worked as the target bacteria to modulate the rumen fermentation by diet; meanwhile, the high age-correlated bacteria such as Succinivibrionaceae_UCG-002 and Fibrobacter also should be considered when shaping the rumen function.
Haematology in the UK: A 60‐year personal perspective

The advances in understanding the pathogenesis, in the diagnosis and classification of blood diseases and in their treatment that have been achieved over the six decades from 1960 to 2020, are reviewed. Emphasis is given to the new techniques, especially in immunology and molecular biology, that have enabled this remarkable progress. The review also highlights the major contributions of UK haematologists and non‐clinical scientists to these advances.
Two-Time-Scale Approach to Characterize the Steady-State Security Region for the Electricity-Gas Integrated Energy System

The knowledge of the steady-state security region is essential for secure operation of the integrated energy system (IES). The two-time-scale feature of the IES is explored to facilitate construction of its exact steady-state security region. Conditions allowing decomposition of the IES into fast and slow subsystems are established. A complete characterization of the IES steady-state security region via the stable equilibrium manifold of the fast subsystem and the slow subsystem is derived and theoretically proven. This characterization can significantly facilitate construction of the IES steady-state security region (SSR) and is derived under the AC power flow model and gas flow model without any model approximation and simplification. Numerical studies are conducted to validate the derived characterization of the SSR and to illustrate the advantages of the proposed characterization in terms of robustness and reduced computational burden. Numerical studies show that exploring the fast and slow subsystems can lead to fast computation of feasible solutions with a 20-fold speed up in calculation time, as compared with the direct integration of the original IES system. Hence, the proposed two-time-scale method appears to be fast and yet accurate.
ECOG-ACRIN E1411 randomized phase 2 trial of bendamustine-rituximab (BR)-based induction followed by rituximab (R) ± lenalidomide (L) consolidation for Mantle cell lymphoma: Effect of adding bortezomib to front-line BR induction on PFS.

7503 Background: Optimal initial therapy for mantle cell lymphoma (MCL) remains uncertain. The randomized phase 2 NCTN trial E1411 tested if progression-free survival (PFS) is prolonged by addition of bortezomib (V) (1.6 mg/m2 SC/IV days 1, 8) to bendamustine-rituximab (BVR vs BR) induction and/or by addition of lenalidomide (L) to rituximab (LR vs R) consolidation. Here we report efficacy and toxicity of induction BVR vs BR. Methods: 373 pts, accrued 2012–16, stratified by MIPI and age (≥60) received 1 of 4 arms: A) BR induction x 6 followed by R x 2 yrs, B) BVR followed by R, C) BR followed by LR or D) BVR followed by LR. Eligible pts had untreated MCL, ≥ age 18 (amended from ≥60 when S1106 for < 65 closed), ECOG PS 0-2 and adequate hematologic and organ function. Pts without progressive disease during induction proceeded to consolidation. Primary induction objective was whether adding bortezomib (BVR) (Arms B + D) to BR (Arms A + C) improves PFS, irrespective of consolidation R vs LR. Design of 360 eligible treated pts would provide 93.8% power to detect 10% improvement in 2-yr PFS from 70% hypothesized for BR, corresponding to 37.4% reduction in hazard using stratified log-rank test at 1-sided 10% alpha. Efficacy population was 179 (BVR) and 180 (BR), induction treatment completed in 144 vs 153, progressive disease during induction 6 vs 7 and registration to consolidation 140 vs 145. Results: Baseline demographics did not differ between the groups, with median age 67 (range 42-90) and 13% < 60 yr, 73% men, ECOG PS 0-1 97%, MIPI Low/Med/Hi 37/29/34%. Estimated PFS at 2 yrs 79.6% BVR (95% CI 73.8-85.9) vs 74.5% BR (95% CI 68.2-81.4) (1-sided stratified log-rank p = 0.268). With median PFS follow-up 51 mos, median PFS estimated at 64.1 and 64.0 mos. Overall response rate (ORR) for BVR was 88.9% (CR 65.5%) vs 89.5% (CR 60.5%) BR (z-test 1 sided p = 0.577 for ORR). Treatment related deaths during induction were 2 in BVR (cardiac arrest, hepatitis) and 1 in BR (tumor lysis). Grade ≥ 3 toxicities were 88.1% (163/185) BVR vs 77.5% (145/187) BR. For BVR vs BR grade ≥ 3 neutropenia occurred in 52 vs 39 pts, though febrile neutropenia (7 vs 6), anemia (7 vs 8) and thrombocytopenia (18 vs 16) did not differ. Peripheral neuropathy (PN) grade 2 was 8 sensory for BVR vs 2 sensory/1 motor for BR, while grade 3 PN was 6 sensory/1 motor for BVR vs 0 with BR. The only non-hematologic grade ≥ 3 toxicity in > 5% of pts was rash (9 vs 12 pts). Conclusions: Bortezomib did not significantly improve the primary endpoint of PFS when added to BR as initial MCL therapy. ORR and CR rates at end of induction were also similar. Follow-up continues to assess the entire treatment regimen, including consolidation R vs LR, but the PFS > 5 yrs, high ORR and MRD negativity rate (Smith et al ASH 2019) in this BR-based trial support BR as a platform for MCL induction therapy. Clinical trial information: NCT01415752.
Ultrasound localization microscopy and functional ultrasound reveal atypical features of the live trigeminal ganglion

The functional imaging of the neurovascular coupling within the trigeminal ganglion (TG) is highly challenging due to its small size and its deep localization. This study combined a methodological framework able to dive into the rat trigeminal nociceptive system by jointly providing first imaging of the trigeminal ganglion blood vasculature at microscopic resolution and the measurement of its neurovascular coupling in the rat TG evoked by corneal stimulations, a robust and clinically-relevant model. Using functional ultrasound imaging (fUS), we were able to image and quantify a strong hemodynamic response in the ipsilateral TG from anesthetized rats, evoked by mechanical or chemical stimulations of corneal nociceptive fibers to intact cornea, even though TG involves less than 300 sensory neurons. The in vivo quantitative imaging of the TG’s vasculature using ultrasound localization microscopy (ULM) combined with ex-vivo (DiI) staining reveals particular features of the vascularization of the area containing the sensory neurons, that is likely the origin of this strong vaso-trigeminal response and due to the nature of this structure at the interface between the peripheral and central nervous systems. This innovative imaging approach opens the path for future studies on the mechanisms underlying changes in trigeminal local blood flow and neurovascular coupling, key mechanisms and readouts for the understanding and treatment of debilitating trigeminal pain conditions.
Economic Growth, Inflation and Monetary Policy in Pakistan: Preliminary Empirical Estimates

In economic policy, construction Inflation is a core variable to be considered that determines the economic activity. To make a suitable monetary policy, it is very essential to check the price level and later on, many other variables are considered to achieve the goal. This study aims to reveal the affiliation of inflation on the growth of economic activities in Pakistan. Time series data set for the period 1989-2020 was used to have the empirical estimates. Augmented Dickey Fuller Unit Root Test is employed to check the unit root of the time series and Auto Regressive Distributive Lag techniques are used for empirical estimates. The present research uses Inflation as a dependent variable and Gross Domestic Product, Interest Rate, Money Supply, and Exchange Rate as the explanatory variables of the study. The findings of this analysis reveal that there's an antagonistic relation between Inflation and GDP.
Otimização do eletrolito polimerico baseado no complexo poli (epicloridrina-co-oxido de etileno) com NaI/I2 para celulas solares de TiO2/corante

As celulas solares de TiO2 sensibilizadas por corante, DSSC, sao constituidas por um filme nanoporoso de TiO2 modificado por um corante fotosensibilizador, um eletrolito no qual esta presente o par redox I¨/I3¨, e um contra-eletrodo de platina. Desde 1996 o Laboratorio de Polimeros Condutores e Reciclagem (LPCR) do Instituto de Quimica da Unicamp vem se dedicando ao desenvolvimento de celulas solares de TiO2/corante de estado solido, atraves do emprego de eletrolitos polimericos. A substituicao do eletrolito liquido por um eletrolito polimerico visa minimizar os problemas decorrentes de vazamento ou evaporacao do solvente, alem de facilitar a montagem dos dispositivos. Estudos anteriores mostraram que as DSSC com eletrolito polimerico apresentam uma baixa estabilidade. Como a durabilidade de um dispositivo e um fator fundamental visando sua producao e uso em larga escala, o objetivo desta dissertacao foi investigar as possiveis causas da baixa estabilidade das DSSC e otimizar a composicao do eletrolito polimerico baseado em poli(epicloridrina-co-oxido de etileno), P(EO-EPI)84:16, NaI e l2, visando obter celulas solares com maior eficiencia e estabilidade. Os resultados obtidos mostraram que a baixa estabilidade destas celulas esta relacionada com a elevada quantidade de solvente residual presente no dispositivo apos o termino de sua montagem. A primeira parte do trabalho consistiu em eliminar esta interferencia. O eletrolito polimerico foi otimizado atraves da adicao do plastificante poli(etileno glicol) metil eter, P(EGME), que levou a uma reducao significativa da temperatura de transicao vitrea (Tg) do material polimerico, aumentando a flexibilidade das cadeias polimericas e tambem participando na coordenacao dos cations Na, levando ao aumento da condutividade do eletrolito polimerico (s = 1,7 x 10 S cm, para 13 % m/m NaI). O coeficiente de difusao estimado para os ions no eletrolito polimerico com plastificante foi de 2 x 10 cms, aproximadamente 5 vezes maior do que para o eletrolito sem plastificante. A adicao do plastificante nao comprometeu as estabilidades termicas, eletroquimicas e dimensionais dos filmes de eletrolito polimerico. A DSSC preparada com o eletrolito de P(EO-EPI) : P(EGME) (1:1) e 13 % (m/m) de NaI/I2 apresentou uma corrente de curto-circuito (ISC) de 1,88 mA cm e eficiencia de conversao de energia (h) de 0,52 % (100 mW cm). Sob 10 mW cm, ISC = 0,60 mA cm e h = 1,75 %. Estes resultados mostram que a adicao do plastificante contribuiu para melhorar o desempenho da celula solar e o estudo de estabilidade desta DSSC mostrou uma reducao de menos de 15 % na eficiencia de conversao de energia apos 30 dias de irradiacao. Abstract
Geochemistry Study of Cross-castic Magma Alkalinity Evolution

The discrimination of magmatic alkalinity is a classic study that has never stopped for the past ninety years. Various methodologies have been developed since Shand’s classification using the method of alumina saturation to approach silica saturation and the methodology without involving alumina and silica such as K 2 O vs. Na 2 O and others, while the aim is to find out the evolution of alkalinity during the magmatic differentiation. The classical magmatic alkalinity evolution has been known as a castic magma alkalinity evolution, where the initial magma in the form of magma-X(a) will evolve along the stages of differentiation and remain a derivative of the initial magma {magmaX(a)}. The same philosophy is also explained in the ternary AFM diagram. Is the magmatic differentiation, followed by fractional crystallization, always an evolution of alkalinity based on caste? This question often raises current debates. This study takes the example of cogenetic volcanic and albitites. The application of the cogenetic volcanic using the selected diagram, which is ‘Three in one an overlaid diagram’. The output of the diagram presents the differentiation of magma which based on the evolution of Mg-series and Fe-series in a discontinuous branch of Bowen 1922 that can take place the castic and cross-castic, e.g. (a) from Mg-series to Mg-series {castic}, (b) from Mg-series to Feseries {cross-castic}, (c) from high-Mg tholeiitic basalt to calc-alkaline series {cross-castic}, (d) from Fe-series to Fe-series {castic}. While the evolution of magmatic alkalinity based on the continuous branch and refer to Trapezoid model generally occurring a cross-castic, e.g . (A) from sodic calc-alkaline to sodic alkaline-calcic, (B) from sodic calc-alkaline to shoshonitic alkaline-calcic, (C) from sodic calc-alkaline to potassic calc-alkaline, (D) from potassic calc-alkaline to shoshonitic alkaline-calcic, (E) sodic alkaline-calcic to sodic alkaline/peralkaline, (F) shoshonitic alkaline-calcic to potassic/ultrapotassic alkaline-calcic (cross-castic in subalkaline), (G) shoshonitic/potassic alkalinecalcic to shoshonitic/potassic alkaline/peralkaline. In this study, Fossa delle Felci volcanics (Italy) shows the evolution of magma from Mg-series to Mg-series, but the evolution of alkalinity of magma reveals the cross-caste (from sodic calc-alkaline to shoshonitic alkaline-calcic). Salak volcanics (Western Jawa) shows the evolution of magma from the Mg-series to Fe-series (cross-castic), and also the cross-castic in the evolution of alkalinity from sodic calc-alkaline to alkaline-calcic. Gothara albitites (India) clearly reveal the sodic-rich alkaline, which the magma generates from the evolution of sodic alkaline-calcic to sodic alkaline without the presence of potassic.
Doped Transition Metal Oxide/CNT: New Heterostructures for Supercapacitor Application

The rapid technological progress of the world in th e 19th and 20th century could largely be attributed t o the extensive use of electricity in the form of sma ll devices such as light bulbs and extending to very large applications such as those in powering large mechanical units in industrial plants. In an increasingly mobile world however, a large number of mobile applications still rely heavily on mechanical and thermal energy generation and storage which are both inefficient and unclean. There is therefore, a pressing need for ‘mobile energy ‘and this makes it imperative for the development of charge storage devices capable of delivering energy in a manner suitable for mobile applications such as automobiles and electronic devices i.e. rapidly over an extended period of tim e with minimal loss over time(1, 2). The need to tail or energy storage devices to suit such applications is highlighted by the current targets established by t he Department of Energy(3) for the same i.e. 7.5 Wh/kg at 625 W/kg lasting upto 15 years. It is this incessant demand that is the driving force fueling various current and emerging technologies including lithium ion batteries, supercapacitors and fuel cel s. Supercapacitors hold a unique place among these energy storage devices on account of their high power density and long cyclability. Supercapacitors are electrochemical charge storage devices capable of delivering large bursts of charge over a very sh ort period of time. It is due to this unique capability that supercapacitors occupy a very important role in the growing alternative energy field. High surface area carbons, hydrated ruthenium oxide (4-6) and MnO 2 are among the primary materials being considered for supercapacitor applications(7-10). Bulk oxide materials are limited due to their electrical conductivity for various electronic and electrochemical applications
Função discriminante de Fisher para classificação do carvão vegetal de clones de Corymbia e Eucalyptus

relação qualidade global do carvão vegetal. Comparando os clones por meio das variáveis canônicas constatou-se que o clone Eucalyptus x o indicado para a produção de carvão vegetal. Não obstante, os clones Corymbia desempenho para Redução de dimensionalidade; Variável canônica. Abstract The objective of this study was averages, it was found that the Eucalyptus grandis x Eucalyptus urophylla clone is the most suitable for charcoal production. Notwithstanding, the clones of the genus Corymbia had a promising performance for utilization in charcoal production.
Recent Relocation Patterns Among Older Adults in the United States

Abstract Problem, research strategy, and findings Residential relocation is a way for older adults to cope with income changes, health changes, and other life cycle events such as the loss of a partner. The number of movers aged 60 and older increased by 1.4 million from 2010 to 2019 in the United States. Therefore, it is timely to examine older adults’ recent relocation patterns. Using multiple national-level data sources, we asked two questions: First, who are movers among older adults, and why are they moving? Second, what are their destination regions and neighborhoods? Results show that movers tend to be renters, those with lower incomes, those with higher housing cost burdens, and those who live alone. Although older adults’ primary reason for relocation is to live closer to their families, baby boomers younger than 70 have more heterogeneous moving reasons than older cohorts. We classify older adult movers into three types: aging adapters (56.9% of movers), suburb lovers (37.5% of movers), and long-distance movers (5.6% of movers). Takeaway for practice Our findings suggest short- and long-term strategies for planners to help older adults meet their heterogeneous residential needs. Practitioners should take steps to increase housing affordability for older adults, such as through changes in land use controls, by creating more age-restricted and age-inclusive communities to accommodate the diverse needs of movers among older adults, and by promoting age-friendly ride-hailing and public transit systems.
The Response of Wheat with Different Allele Statuses of the Gpc-B1 Gene under Zinc Deficiency

The aim of this study was to investigate the effect of zinc (Zn) deficiency on the growth and grain yield of wheat with different allele statuses of the Gpc-B1 gene. For this research, common wild emmer wheat (Triticum turgidum ssp. dicoccoides (Koern. ex Asch. &Graebn.) Schweinf. ), bread wheat (Triticum aestivum L. cv. Festivalnaya), and two intogressive lines were used. T. dicoccoides and introgressive line 15-7-1 carry a functional allele of the Gpc-B1 gene, while the T. aestivum cv. Festivalnaya and introgressive line 15-7-2 carry the non-functional Gpc-B1 allele. Zn deficiency did not affect the shoot height or fresh weight of any of the studied plants. The only exception was T. dicoccoides, where a small decrease in shoot height was registered. Additionally, under Zn deficiency T. dicoccoides had an increase in flag leaf area, spike length, and dry weight, as well as in grain number and grain yield per spike. The other variants did not experience changes in the above-described parameters under Zn deficiency. Under Zn deficiency, the Zn concentration in the grains was higher in the plants with a functional allele of the Gpc-B1 gene compared to the plants with a non-functional allele. These results show that wheat with a functional allele of the Gpc-B1 gene growing under Zn deficiency is capable of grain production with a sufficient Zn concentration without a decrease in yield.
CHLOROMETHYL-DICHLOROPHOSPHANE: A USEFUL REAGENT FOR THE SYNTHESIS OF NEW HETEROCYCLES WITH DICOORDINATE PHOSPHORUS

Abstract Only a limited number of heterophospholes are known. A general synthesis1 involves the [4 + 1]-cyclocondensation of a reactive phosphorus(III) compound with an appropriate four-membered chain, as in the synthesis of the 2H-1,2,3-diazaphospholes.2 The limiting factor in this case is the poor availability of four-membered chains with the necessary functionality at the ends.
Sentinel Node Biopsy After Neoadjuvant Chemotherapy In Breast Cancer: Real Life Results

Purpose: compare demographic, clinical and treatment characteristics of women undergoing neoadjuvant chemotherapy (NAC) for breast cancer (BC) treatment according to the axillary approach and analyze factors associated with the indication of sentinel lymph node biopsy (SLNB) in a real-life scenario. Methods: retrospective cohort study in women diagnosed with BC with indication for NAC. Demographic, clinical, tumor, surgical and adjuvant treatment variables were obtained. A univariate logistic regression was performed to evaluate the independent factors associated with SLNB indication and a multiple model was applied for adjustments. Results: A total of 918 patients were included in this study, 161 (17.5%) of whom underwent SLNB, 105 (11.4%) who underwent SLNB followed by AL and 652 (71.0%) who underwent AL only. Concerning the adjusted model, women in stage III were 95% less likely to be submitted to an SLNB (OR = 0.05 95% CI 0.01-0.17; p<0.001) compared to those in stage I. Women who underwent mastectomies exhibited a 90% lower chance of undergoing SLNB than those who underwent conservative surgery (95% CI 0.06-0.17; p <0.001). Considering NAC responses, cases with no response or presenting disease progression exhibited a 55% lower chance of undergoing SLNB compared to those displaying a total response (OR = 0.45 95% CI 0.24-0.82; p = 0.009). Conclusion: SLNB was performed in 29% of the patients following NAC. Patients presenting a more advanced clinical stage of the disease with a worse NAC response and those who underwent mastectomies were less likely to undergo SLNB.