Miracle-dz/UniFAR-FTUs huggingface dataset:
On Wave Resistance

The case here considered is that of a solid whose dimensions are small compared with its depth below the free surface, travelling horizontally under water. The particular case of a circular cylinder advancing at right angles to its length was easily solved from considerations of group-velocity. The more difficult problem of the sphere was worked out by Havelock by direct calculation of the pressures exerted on its surface. In a subsequent paper this rather arduous process was avoided by a calculation of the travelling pressures, applied to the free surface, which would produce the same wave system. The work done by these must be equivalent to that which, in the actual case, is expended on the sphere to maintain its motion. The same principle was further employed by him to find the wave-resistance of other solids of revolution, in particular that of a spheroid. There would appear to be room for an investigation on a more general plan in which no restriction is made as to the form of the solid, which affects only the values to be attributed to certain constants (familiar in another connection) in the final results. For example, it is not necessary even to assume that the solid is moving in one of the directions of free “permanent translation” of which it is capable, and some attention is paid to cases where this condition is departed from. As a further variation from previous methods a small viscous force is introduced, and the work done against resistance is equated to the dissipation of energy.
The definitive rediscovery of Telmatobiushalli (Anura, Telmatobiidae) at its historic type locality and its synonymy with T.dankoi and T.vilamensis

﻿Abstract Telmatobiushalli was the first representative of its genus to be described exclusively for Chile, yet for 85 years no new individuals could be located due to the vagueness with which its type locality was described. The type series was collected by one of the members of the International High Altitude Expedition to Chile (IHAEC) of 1935. Recently, three studies successively claimed to have located the type locality in different places. The third study proved, according to the chronicles of the IHAEC, that the actual locality is Miño, at the origin of the Loa River, where currently there are no published records of Telmatobius. In this study, additional documentary antecedents and graphic material are provided that corroborate that Miño is indeed the type locality of T.halli. Additionally, the recently rediscovered Telmatobius population from Miño and the environment it inhabits are described. The external characteristics of the frogs are consistent with the description of T.halli. Furthermore, molecular phylogenetic analyses were performed that showed that T.halli, T.dankoi, and T.vilamensis, all known only from their type localities in Chile, comprise a clade without internal resolution. A detailed comparison of the diagnoses of the three species revealed that the few phenotypic differences between these taxa were based on characteristics that vary widely within and between populations of the genus, hence their conspecificity is proposed. The implications of this synonymy for the taxonomy, biogeography, and conservation of the Telmatobius from the extreme south of its distribution in Chile are discussed.
The Role of Accommodation Enterprises in the Development of Sustainable Tourism

One of the obstacles to the success of sustainable tourism development is that the roles and responsibilities of the stakeholders in the destination are not clearly defined. This research aims to determine sustainable business practices, corporate social responsibility activities, the obstacles encountered while performing these activities, and the provided benefits within the roles and responsibilities of accommodation enterprises. The study used a phenomenology research design, a qualitative study method. A semi-structured interview form was implemented to 19 senior managers of 22 accommodation enterprises in Alanya that have environmentally friendly certificates. The results showed that the managers of the accommodation enterprises considered themselves responsible for the protection and development of the environment and that the sustainable business practices they performed were mostly ecological. It was also revealed that managers of accommodation enterprises should pay more attention to planning, which is one of the basic principles of sustainable tourism. The study’s main contribution is that it discusses sustainable business practices and corporate social responsibility activities together to determine the roles of accommodation enterprises in sustainable tourism development. Besides that, it also examines the factors that prevent sustainable business practices and their benefits. Considering that few empirical studies holistically discuss the role of accommodation enterprises in the sustainable development of tourism, this study is expected to provide a significant contribution to the literature. Deficiency of planning, mainly performing ecologically sustainable business practices, and the necessity of an effective governance system are among the implications of the research.
Chronological Appearance of Endocrine and Metabolic Dysfunctions Induced by an Unhealthy Diet in Rats

Background and Objectives: The work was aimed to determine the chronological sequence of events triggered by a fructose-rich diet (FRD) (10% w/v in the drinking water) in normal rats. Material and Methods: Serum parameters, liver and islet markers of metabolism, inflammation and oxidative stress were determined weekly for 21 days. Results: At the end of the first week, rats fed with a FRD showed an early increase in circulating triglycerides, fat liver deposit, and enzymatic activity of liver glucokinase and glucose-6-phosphate dehydrogenase (G6P-DH). After two weeks of such a diet, liver glucose-6-phosphatase (G6Pase) activity and liver oxidative stress markers were significantly increased. Liver sterol regulatory element-binding protein 1c (SREBP1c) mRNA also increased in the second week while their target genes fatty acid synthase (FAS) and glycerol-3-phosphate dehydrogenase (GPAT) enhanced their expression at the third week. Liver and pancreatic inflammation markers also enhanced their gene expression in the last week of treatment. Whereas both control and FRD rats remained normoglycemic throughout the entire period of treatment, blood insulin levels were significantly higher in FRD animals at the third week, thereby evidencing an insulin-resistant state (higher HOMA-IR, HOMA-B and HIS indexes). Pancreatic islets isolated from rats fed with a FRD for 3 weeks also increased glucose-induced insulin secretion (8.3 and 16.7 mM). Conclusions: FRD induces asynchronous changes involving early hypertriglyceridemia together with intrahepatic lipid deposit and metabolic disturbances from week one, followed by enhanced liver oxidative stress, liver and pancreas inflammation, pancreatic β-cell dysfunction, and peripheral insulin-resistance registered at the third week. Knowledge of time-course adaptation mechanisms involved in our rat model could be helpful in developing appropriate strategies to prevent the progression from prediabetes to Type 2 diabetes (T2D) triggered by unhealthy diets.
Fatigue Behavior of Smart Composites with Distributed Fiber Optic Sensors for Offshore Applications

Continuous inspection of critical zones is essential to monitor the state of strain within offshore wind blades, thus, enabling appropriate actions to be taken when needed to avoid heavy maintenance. Wind-turbine blades contain various substructures made of composites, sandwich panel, and bond-joined parts that need reliable Structural Health Monitoring (SHM) techniques. Embedded, distributed Fiber-Optic Sensors (FOS) are one of the most promising techniques that are commonly used for large-scale smart composite structures. They are chosen as monitoring systems for their small size, being noise-free, and low electrical risk characteristics. In recent works, we have shown that embedded FOSs can be positioned linearly and/or in whatever position with the scope of providing pieces of information about actual strain in specific locations. However, linear positioning of distributed FOS fails to provide all strain parameters, whereas sinusoidal sensor positioning has been shown to overcome this issue. This method can provide multiparameter strains over the whole area when the sensor is embedded. Nevertheless, and beyond what a sensor can offer as valuable information, the fact remains that it is a “flaw” from the perspective of mechanics and materials. In this article and through some mechanical tests on smart composites, evidence was given that the presence of embedded FOS influences the mechanical behavior of smart composites, whether for quasi-static or fatigue tests, under 3-point bending. Some issues directly related to the fiber-architecture have to be solved.
Using full wafer defect maps as process signatures to monitor and control yield

Experience with full-wafer data maps at many fabs has shown that defects on patterned wafers tend to cluster and be distributed in nonrandom patterns. The full-wafer defect map becomes a process signature which can be used to quickly determine if changes have occurred in the process. The authors show how the process signature map has been used in actual case studies to quickly identify process problems, often before an operator or engineer reviews any actual defects on the wafer. Fast optical processing, optical pattern filtering and holography, as used in the Insystems 8600 and the more advanced 8800, achieve sensitivity to submicron (and larger) defects across the full wafer. This allows for faster defect analysis and response time. <<ETX>>
The effective period and damping of a class of hysteretic structures

This paper presents the results of a numerical investigation in which the maximum response of six hysteretic systems is calculated for an ensemble of twelve earthquakes. Inelastic response spectra are constructed for a range of response ductility. An effective linear period and damping are calculated for each system and ductility by determining those parameters which minimize an RMS response spectrum error. Conclusions are presented concerning the effects of deterioration, stiffness degradation, cracking and ductility on the effective linear system parameters.
CD40 Agonists Alter the Pancreatic Cancer Microenvironment by Shifting the Macrophage Phenotype toward M1 and Suppress Human Pancreatic Cancer in Organotypic Slice Cultures

Background/Aims CD40 agonists are thought to generate antitumor effects on pancreatic cancer via macrophages and T cells. We aimed to investigate the role of CD40 agonists in the differentiation of macrophages and treatment of human pancreatic adenocarcinoma. Methods Immunohistochemistry was performed on paraffin-embedded surgical blocks from patients with pancreatic cancers to evaluate macrophage phenotypes and their relationship with survival. The effects of CD40 agonists on macrophage phenotypes and human pancreatic cancer were evaluated utilizing cell cocultures and organotypic slice cultures. Results CD163+ (predominant in M2 macrophages) and FOXP3+ (predominant in regulatory T cells) expression levels in the tumors were significantly lower in patients with stage IB pancreatic cancer than in those with stage II or III disease (p=0.002 and p=0.003, respectively). Patients with high CD163+ expression had shorter overall survival than those with low CD163+ expression (p=0.002). In vitro treatment of THP-1 macrophages with a CD40 agonist led to an increase in HLA-DR+ (predominant in M1 macrophages) and a decrease in CD163+ expression in THP-1 cells. Cell cocultures showed that CD40 agonists facilitate the suppression of PANC-1 human pancreatic cancer cells by THP-1 macrophages. Organotypic slice cultures showed that CD40 agonists alter the pancreatic cancer microenvironment by shifting the macrophage phenotype toward M1 (increase HLA-DR+ and decrease CD163+ expression), decreasing the abundance of regulatory T cells, and increasing tumor cell apoptosis. Conclusions CD163 is related to advanced human pancreatic cancer stages and shorter overall survival. CD40 agonists alter macrophage phenotype polarization to favor the M1 phenotype and suppress human pancreatic cancer.
‘For Japan Only?’ Crossing and Re-inscribing Boundaries in the Circulation of Adult Computer Games

This chapter considers how and why 'Japan' comes to matter in the circulation of games in a globalised world by examining the consumption of adult video games inside and outside Japan. Despite the export of Japanese video games abroad, adult computer games are often seen to be distinctively 'Japanese. ' This chapter argues that adult video games are a niche genre; producers and players form a close-knitted community that is suspicious of non-Japanese out of the fear that the Western media will widely report such games. Western reports about such games have led the international community to put pressure on the Japanese government to stamp out such genre. While some in the adult game community believe that it'd be the best if the game would only be played by Japanese inside the country, others are keen to expand the community outside Japan. The chapter concludes by suggesting the need to go beyond national and nationalising discourse to see the nuance of interactions within national borders and exceeding them.
Troubleshooting and Maintaining Cisco IP Networks (Tshoot) Foundation Learning Guide: (ccnp Tshoot 300-135)

Troubleshooting and Maintaining Cisco IP Networks (TSHOOT) Foundation Learning Guide Troubleshooting and Maintaining Cisco IP Networks (TSHOOT) Foundation Learning Guide is your Cisco authorized learning tool for CCNP TSHOOT 300-135 exam preparation. Part of the Cisco Press Foundation Learning Guide series, it teaches you how to maintain and monitor even the most complex enterprise networks. Youll compare and master todays leading approaches to troubleshooting, including an efficient structured process for maximizing network uptime in the context of your own organizations policies and procedures. Coverage includes gathering information, capturing traffic, using event notifications, working with maintenance and trouble-shooting tools, and more. Throughout, each chapter opens with a list of topics that clearly identify its focus. Each chapter ends with a summary of key concepts for quick study, as well as review questions to assess and reinforce your understanding. To deepen your hands-on expertise and strengthen your exam readiness, this guide also presents five full chapters of real-world troubleshooting case studies. This guide is ideal for all certification candidates who want to master all the topics covered on the TSHOOT 300-135 exam. --The official textbook for the Cisco Networking Academy CCNP TSHOOT 300-135 course --Thoroughly introduces proven troubleshooting principles and common troubleshooting approaches --Defines structured troubleshooting and reviews its subprocesses --Shows how to integrate troubleshooting into day-to-day network maintenance processes --Covers information gathering on Layer 2 switching and Layer 3 routing with IOS show and debug commands, ping, and telnet --Introduces specialized tools for capturing traffic, gathering information (SNMP and NetFlow), and receiving network event notifications (EEM) --Uses extensive troubleshooting examples and diagrams to support explanations and strengthen your understanding --Presents self-assessment review questions, chapter objectives, and summaries to facilitate effective studying
APPLICATION OF ADSORBENTS IN RADIONUCLIDE SEPARATION FOR RADIO-CHRONOMETRY PURPOSES

The aim of this work is the application of well-known adsorbents for the separation of 90Sr, 90Y, and 90Zr radionuclides. Three basic types of adsorbents have been studied: Dowex HCR S/S cation exchange resin, Dowex 1x8 anion exchange resin, and titanium dioxide with a chemically modified surface. The most effective adsorbent for the separation of strontium, yttrium, and zirconium ions was titanium dioxide with a chemically modified surface. This adsorbent selectively absorbs zirconium cations against the background of excess strontium and yttrium ions. The separation takes place in 2% HNO3 at initial concentrations of the studied cations 10 ng/ml and 100 ng/ml. Analysis of the initial mixture and the mixture after separation was conducted using ICP-MS “Element-2” with argon plasma. Age of 90Sr-90Y β-source (approximately 30.2 years old) was measured using the method of the chemical separation of 90Sr and 90Zr by the titanium dioxide and following calculation of the 90Zr/90Sr ratio. The age of 90Sr-90Y β-source was calculated as 31.9 ±1 year. The combination of liquid scintillation counting of 90Sr and ICP-MS analysis was proposed as an alternative method of determination of the 90Zr/90Sr ratio. It was shown, that both methods provide similar results in radio chronometry of 90Sr-contained compound, i.e. age-dating of liquid 90Sr-90Y β-source, and could validate each other.
BISoN: A Bayesian Framework for Inference of Social Networks

Social networks are often constructed from point estimates of edge weights. In many contexts, edge weights are inferred from observational data, and the uncertainty around estimates can be affected by various factors. Though this has been acknowledged in previous work, methods that explicitly quantify uncertainty in edge weights have not yet been widely adopted, and remain undeveloped for many common types of data. Furthermore, existing methods are unable to cope with some of the complexities often found in observational data, and do not propagate uncertainty in edge weights to subsequent statistical analyses. We introduce a unified Bayesian framework for modelling social networks based on observational data. This framework, which we call BISoN, can accommodate many common types of observational social data, can capture confounds and model effects at the level of observations, and is fully compatible with popular methods used in social network analysis. We show how the framework can be applied to common types of data and how various types of downstream statistical analyses can be performed, including non-random association tests and regressions on network properties. Our framework opens up the opportunity to test new types of hypotheses, make full use of observational datasets, and increase the reliability of scientific inferences. We have made example R scripts available to enable adoption of the framework.
Late-Onset Leber’s Hereditary Optic Neuropathy with Concurrent Retinal Detachment and Retrobulbar Visual Pathway Involvement

ABSTRACT We report a case of late-onset Leber’s hereditary optic neuropathy (LHON) with concurrent retinal detachment, mild retinal pigment epithelial changes, cataract and hyperintensity on fluid-attenuated inversion recovery magnetic resonance imaging affecting the entire retrobulbar visual pathway. We also documented that progression of the visual field defect correlated with retinal nerve fibre layer and ganglion cell layer-inner plexiform layer changes on optical coherence tomography. Our case provides further understanding of LHON as a disorder of the entire pre-geniculate pathways and also highlights that detailed history taking in addition to recognition of typical sequential optic disc appearance and visual field characteristics at different stages of LHON remain critical even in this era of modern imaging, autoimmune biomarkers and genetic testing.
STUDY OF DYNAMIC MODES OF THE SPEED-OPTIMIZED ELECTRIC DRIVE CONTROL SYSTEM UNDER CONDITIONS OF ALTER THE DESIGN VOLTAGE AMPLITUDE

The relevance of the work is due to the need to adapt the methods of the theory of optimal control to modern technical capabilities. The complexity of optimization of control systems by variational methods led to the creation of the N–i switching method. It is characterized by the simplicity of the mathematical apparatus, however, certain methodological aspects encourage research aimed at improving this method with a focus on software implementation. The purpose of this study is to develop the mathematical apparatus of the N–i switching method by developing a technique for correcting the settings of cascade structure relay systems for speed control of electric drives, based on the use of empirically obtained data. To achieve this goal, the following tasks were solved in the work: the parameters of the mathematical model of the electric drive were calculated, on which a series of numerical experiments were performed under the conditions of varying the calculated amplitude of the voltage of the power converter, which made it possible to reveal a stable pattern of changes in the speed of the system depending on the coefficient of the calculated voltage; built a calibration diagram, which is designed to determine the correction factor in the entire range of speed control. The revealed regularity is based on the indirect influence of the varied parameters on the conditions of controllers switching, the moments of occurrence and the nature of their sliding modes. The result of the work is a method for correcting the parameters of relay controllers, which brings the duration of the speed control of the electric drive closer to the empirically set optimal value. Its implementation does not require the involvement of large additional resources and provides an improvement in the quality of transient processes. The empirical component of the proposed optimization method consists not in the direct selection of one of the key parameters of the system, but in the preliminary refinement of the initial data, which is effective within the used synthesis method. The prospect of this study is an analytical solution to the problem of determining the correction coefficient, which will contribute to the practical application of the proposed optimization algorithm.
Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer’s Disease

Glial fibrillary acidic protein (GFAP) is an intermediate filament structural protein involved in cytoskeleton assembly and integrity, expressed in high abundance in activated glial cells. GFAP is neuroprotective, as knockout mice are hypersensitive to traumatic brain injury. GFAP in cerebrospinal fluid is a biomarker of Alzheimer’s disease (AD), dementia with Lewy bodies, and frontotemporal dementia (FTD). Here, we present novel evidence that GFAP is markedly overexpressed and differentially phosphorylated in AD hippocampus, especially in AD with the apolipoprotein E [ε4, ε4] genotype, relative to age-matched controls (AMCs). Kinases that phosphorylate GFAP are upregulated in AD relative to AMC. A knockdown of these kinases in SH-SY5Y-APPSw human neuroblastoma cells reduced amyloid accrual and lowered protein aggregation and associated behavioral traits in C. elegans models of polyglutamine aggregation (as observed in Huntington’s disease) and of Alzheimer’s-like amyloid formation. In silico screening of the ChemBridge structural library identified a small molecule, MSR1, with stable and specific binding to GFAP. Both MSR1 exposure and GF AP-specific RNAi knockdown reduce aggregation with remarkably high concordance of aggregate proteins depleted. These data imply that GFAP and its phosphorylation play key roles in neuropathic aggregate accrual and provide valuable new biomarkers, as well as novel therapeutic targets to alleviate, delay, or prevent AD.