Miracle-dz/UniFAR-FTUs huggingface dataset:
MacrophagesArthritis by Inhibiting IL-1 Signal on IL-1R Type 2 Suppresses Collagen-Induced

IL-1 a and IL-1 b (in this article referred to as IL-1) play important roles in host defense against infection and inﬂammatory diseases. IL-1R1 is the receptor for IL-1, and IL-1R2 is suggested to be a decoy receptor, because it lacks the signal-transducing TIR domain in the cytoplasmic part. However, the roles of IL-1R2 in health and disease remain largely unknown. In this study, we generated EGFP-knock-in Il1r2 2 / 2 mice and showed that they were highly susceptible to collagen-induced arthritis, an animal model for rheumatoid arthritis in which the expression of IL-1R2 is augmented in inﬂammatory joints. Il1r2 was highly expressed in neutrophils but had only low expression in other cells, including monocytes and macrophages. Ab production and T cell responses against type II collagen were normal in Il1r2 2 / 2 mice. Despite the high expression in neutrophils, no effects of Il1r2 deﬁciency were observed; however, we found that production of inﬂammatory mediators in response to IL-1 was greatly enhanced in Il1r2 2 / 2 macrophages. These results suggest that IL-1R2 is an important regulator of arthritis by acting speciﬁcally on macrophages as a decoy receptor for IL-1. The Journal of Immunology , 2015, 194: 000–000. nterleukin-1, of two molecular species IL-1 a and IL-1 b , is an inﬂammatory cytokine that important roles in host
Performance Evaluation And Modeling Of TheActivated Sludge System Used In Riqqa, Kuwait

The wastewater treatment plant (WWTP) located in Riqqa, Kuwait, has shown signs of instability. The chemical oxygen demand (COD) in the secondary effluent COD was found to be particularly unstable (fluctuating sharply between 30 and 200 mg/l). This paper presents the performance evaluation conducted by the Kuwait Institute for Scientific Research (KISR) of the activated sludge system, at Riqqa plant. Probable causes are indentified, and a mathematical model is developed. In addition to the system performance records for 2004– 2007, the results of a sampling campaign conducted from March 2009 to March 2010 were also used in the evaluation of the activated sludge system, based on influent and effluent qualities and common operating variables, e.g., hydraulic retention time (HRT), solids retention time (SRT), volumetric organic load (Lv) and food-to-microorganism ratio (F/M). The system was then modeled in a SIMBA platform, using Activated Sludge Model No. 1 (ASM1). The results obtained results indicated that the quantity and degree of biodegradability, i.e. biological oxygen demand-to-chemical oxygen demand ration (BOD/COD) of the wastewater being treated fluctuated greatly, probably due to the illegal discharge of industrial wastewaters or septage. The system, which is controlled manually, was repeatedly being operated outside optimal ranges. To maintain a high quality of treatment, it is recommended that automatic flow controllers be installed in recirculated activated sludge (RAS) and wasted activated sludge (WAS) streams, and that protective strategies be implemented to prevent the discharge of industrial and other toxic or inhibitory substances into the system. The developed model can be used to control and optimize the performance of the system.
The discussion about origin of fuzzy uncertainty of remote sensing data and processing methods

In recent years,remote sensing information has been used more widespreadly,and data uncertainty is more obvious.The article mainly makes the further analysis to the remote sensing data quality:including inherent uncertainty of the remote sensing information itself and the uncertainty which was introduced by the remote sensing data analysis and processe.Based on the reasons for the summary uncertainty existence,the processing method of uncertainty is introduced.
Qualitative and quantitative evaluation of computed tomography changes in adults with cystic fibrosis treated with elexacaftor-tezacaftor-ivacaftor: a retrospective observational study

Introduction: The availability of highly effective triple cystic fibrosis transmembrane conductance regulator (CFTR) modulator combination therapy with elexacaftor–tezacaftor–ivacaftor (ETI) has improved pulmonary outcomes and quality of life of people with cystic fibrosis (pwCF). The aim of this study was to assess computed tomography (CT) changes under ETI visually with the Brody score and quantitatively with dedicated software, and to correlate CT measures with parameters of clinical response. Methods: Twenty two adult pwCF with two consecutive CT scans before and after ETI treatment initiation were retrospectively included. CT was assessed visually employing the Brody score and quantitatively by YACTA, a well-evaluated scientific software computing airway dimensions and lung parenchyma with wall percentage (WP), wall thickness (WT), lumen area (LA), bronchiectasis index (BI), lung volume and mean lung density (MLD) as parameters. Changes in CT metrics were evaluated and the visual and quantitative parameters were correlated with each other and with clinical changes in sweat chloride concentration, spirometry [percent predicted of forced expiratory volume in one second (ppFEV1)] and body mass index (BMI). Results: The mean (SD) Brody score improved with ETI [55 (12) vs. 38 (15); p < 0.001], incl. sub-scores for mucus plugging, peribronchial thickening, and parenchymal changes (all p < 0.001), but not for bronchiectasis (p = 0.281). Quantitatve WP (p < 0.001) and WT (p = 0.004) were reduced, conversely LA increased (p = 0.003), and BI improved (p = 0.012). Lung volume increased (p < 0.001), and MLD decreased (p < 0.001) through a reduction of ground glass opacity areas (p < 0.001). Changes of the Brody score correlated with those of quantitative parameters, exemplarily WT with the sub-score for mucus plugging (r = 0.730, p < 0.001) and peribronchial thickening (r = 0.552, p = 0.008). Changes of CT parameters correlated with those of clinical response parameters, in particular ppFEV1 with the Brody score (r = −0.606, p = 0.003) and with WT (r = −0.538, p = 0.010). Discussion: Morphological treatment response to ETI can be assessed using the Brody score as well as quantitative CT parameters. Changes in CT correlated with clinical improvements. The quantitative analysis with YACTA proved to be an objective, reproducible and simple method for monitoring lung disease, particularly with regard to future interventional clinical trials.
Survival Analysis and Failure Modes of Total Hip Arthroplasty Using a Cemented Semi-Retentive Acetabular Cup

To reduce the incidence of total hip revisions, there have been continuous efforts to enhance prosthetic materials and designs to optimize implant survival. A primary implant with a constrained acetabular component is often used to minimize the risk of dislocations even though this approach has some drawbacks as reported in the literature. To address these concerns, this study aimed to assess the survivorship and dislocation rate of a semi-retentive cemented acetabular cup when used as a primary implant. The specific cemented cup that we studied was not present in any study that we consulted, so to fill this gap, we conducted a retrospective examination of 527 cemented hip prostheses that utilized the semi-retentive cup between the years 2005 and 2012. We employed Cox multiple regression models for our statistical analysis. The revision due to dislocation occurred in 12.8% of all cases, with a lower incidence of 5% (14 cases) in age groups >70 years than in age groups <70 years (14%—32 cases) (p < 0.001). The survival rates of the semi-retentive cemented acetabular cup were 98.6% (520 cases) at 5 years and 92.2% (487 cases) at 10 years. The survival rates were significantly lower in women than men, with 1.9% (7 cases) toward 0% at 5 years and 8.1% (30 cases) toward 5% (7 cases) at 10 years (p = 0.002). The difference in failure rates between age groups over 70 years (2.3%—10 cases) and age groups under 70 years (11.5%—34 cases) was also statistically significant (p < 0.001). Our study indicates that the semi-constrained design may cause frequent damage to the polyethylene liner due to impingement and wear, which are the primary factors for failure. Also, this implant has a similar risk of revision due to dislocation as reported in studies and may be beneficial as a primary implant in elderly patients with low-demanding lifestyles, muscular insufficiency, and low compliance regarding hip prosthetic behavior, without a major effect on survivorship.
A Monolithic Gallium Nitride Driver with Zero-Voltage-Switching and Dead Time Control

The Gallium Nitride (GaN)-based synchronous buck converter can reduce the power loss on the rectifier diode in an asynchronous buck converter. Dead time should be applied to avoid the shoot-through problem, while the length of the dead time will affect the efficiency of the synchronous buck converter. Therefore, the optimization of dead time is required to improve transmission efficiency. This paper proposes a driver circuit for the synchronous buck converter based on GaN devices with zero-voltage-switching (ZVS) capability and dead time self-adjustment. This work is based on advanced design system (ADS) software. The simulation results indicate that the dead time was reduced from 0.5 $\mu$s to 0.084 $\mu \mathrm{s}$, and the efficiency can be improved from 87.82% to 94.18% when the load resistance is 50 $\Omega$.
Hyperspectral Image Classification Based on Interactive Transformer and CNN With Multilevel Feature Fusion Network

Due to the powerful feature information mining ability of deep learning, models such as convolutional neural network (CNN) and Transformer have gained a certain progress in hyperspectral image classification (HSIC). Characteristically, the CNN is good at extracting local information, but it has the limitation of insufficient receptive field. While the Transformer has the advantage of global representation, it ignores local details to some extent. Therefore, this letter proposes an interactive Transformer and CNN with a multilevel feature fusion network (ITCNet) for HSIC. Specifically, in the image-based framework, features with different perceptual fields and depths are extracted interactively by a multilayer Transformer and CNN, then fused through a multilevel feature fusion module for class prediction. Experimental results on two real datasets verify its efficiency, with improvements over other related methods.
Hyperspectral Image Classification Based on Masked Self-Supervisied Pretraining Network

Hyperspectral image (HSI) classification is a fundamental research in the field of HSI processing, which has made great development, especially after deep learning-based method is widely used in this field. These methods are commonly starved for labeled samples. However, it is more challenging to obtain labeled samples than HSI in practice. Fortunately, self-supervised leaning (SSL) can take advantage of unlabeled data. In this paper, an HSI classification method based on masked self-supervised network (MSSL) is proposed. To obtain a representative and label-independent representation of HSI, a novel masking and reconstruction based proxy task is designed to accomplish SSL. Furthermore, a spatial masking strategy for HSIs is employed due to the high similarity of adjacent objects in remote sensing images. Experimental results on two benchmark HSI datasets indicate that the proposed MSSL can achieve better classification results with small number of labeled samples.
Contributions of Litter-fall to Soil Respiration and Its Affacting Factors in Southern Subtropical Forests of China

Three main types of Soil respirations(S+L and S) in southern subtropical forests in Dinghushan biosphere reserve were consecutively being monitored over 31 months by the approach of static chamber-gas chromatograph techniques.Research shows that: annual mean contribution rates of litter-fall to soil respiration in the monsoon evergreen broadleaf forest(BF),mixed broadleaf-coniferous forest(MF) and coniferous(pine) forest(PF) reached 27.82%、33.29%和36. 35% respectively;Moreover,all three types of forests displayed the same seasonal dynamic features with the peaks contributions of them were from April to September,which accounts for 71.87%、61.89% and 70.39% of annual total contributions of litter-fall to soil respiration respectively.Soil respiration(S+L) had an obviously positive relationship with the seasonal changes of litter-fall input(P0.001;And soil water content had a significant impact on the contribution of litter-fall to soil respiration in the three types of forests(P0.001);Soil temperature had positive correlativity with soil respiration flux,though it has no distinctive relationship with contribution of litter-fall to soil respiration;the contribution ratios of litter-fall to soil respiration on rainy days were 28.63%、38.20% and 40.12% respectively,which were significantly higher than those in the sunny days in the three types of forests.
Microbase Cloud Products and Associated Heating Rates in the Tropical Western Pacific

The microbase value added product (Miller et al. 2003) provides a standardized framework for calculating and storing continuous retrievals of cloud microphysical properties including liquid water content (LWC), ice water content (IWC), and cloud droplet size. Microbase is part of the larger broadband heating rate profile (BBHRP) project that provides a similar framework for vertical profiles of radiative heating rates. The initial development efforts for microbase and BBHRP have utilized observations from the Southern Great Plains facility. We have obtained the microbase code and have processed one month of data each for Manus (February-March 2000) and Nauru (June-July, 1999; the Nauru99 intensive operational period). The Manus period was selected because it corresponded to a period with a transition from convectively suppressed to active conditions. The Nauru99 period was chosen because of the increased frequency of sonde launches during the intensive operations period. The Nauru99 also represented one of the most convectively active at Nauru during the first several years of operation at that site.
International Journal of Current Research in

Article Info The purpose of the present study was to analyse the genetic variance (additive, dominance, epistatic) of milk yield and the resulting genetic effects in Bulgarian Dairy Synthetic Population (BDSP) sheep in the framework of an experiment for introduction of Chios and Lacaune sheep in the breeding and selection schedule of BDSP. A test-day model was used including daily milk yields as separate observation. The observed genetic variance was substantial, comprising 0.33 of the total variance. The proportion of the additive genetic variance was 0.23, while that of nonadditive: 0.10 of the total variance. The observed genetic effects were statistically significant, and dominance genetic effect was positive (137.18). Additive genetic effect was also positive (27.86), and together with the dominance variance it constituted the major part of genetic variance. The epistatic genetic effect was negative (-33.15). The estimates of additive genetic effects and non-additive deviations for tested genetic groups showed diversity and deviations depending on the percentage of blood of the different breeds and pathways of genotypes’ formation. Accepted: 07 March 2017 Available Online: 20 April 2018
International Journal of Current Research in

Acetyl-CoA C-acetyltransferase (AACT) is one of key genes in the cytosolic mevalonate (MVA) biosynthetic pathway which regulate the terpenoid biosynthesis. To analyse the function of AACT gene in terpenoid biosynthesis in Chamaemelum nobile, we cloned a AACT gene (CnAACT, GenBank accession number MF662816) from C. nobile using RTPCR method. The full-length cDNA of CnAACT gene is 1727bp which contains an open reading frame (ORF) of 1224bp, encoding a 408 amino-acid protein. The theoretical molecular weight and pI of the CnAACT are 4.83kDa and 6.25, respectively. Multialignment comparison analysis showed the protein sequence of CnAACT had high similarity with AACT proteins from other plants. Furthermore, several conserved domain of AACT protein were found in CnAACT, suggesting CnAACT is one of AACT family members. The cloning and characterization of CnAACT provided basic data for further studying the function of CnAACT in the sesquiterpene biosynthesis in C. nobile. Accepted: 24 August 2017 Available Online: 06 October 2017
International Journal of Current Research in

Date of Publication: 06 August 2019 Concentrations of iron and manganese that exceed critical limits in soil and plant provide opportunities for microorganisms to become resistant. The aim of this study was to identify endomycorrhizal fungi from areas contaminated with iron and manganese for use as biostarter for phytorizoremediation programs. This research was conducted in two phases at April 2019, namely taking rhizosphere from Chromolaena odorata, Melastoma affine dan Spathoglottis plicata in Sorowako, Indonesia; and the second phase is to isolate and identify endomycorrhizal fungal spores in the Microbiology Laboratory, Center for Environmental and Forestry Research and Development in Makassar, Indonesia. The results showed that the genus Acaulospora was more dominant in areas that were contaminated with iron and manganese, and were able to adapt and survive compared to other genera. Keywords
International Journal of Current Research in

Iron mining activities generate huge amount of mine spoil dumped in the form of overburden, which represents nutrient deficient situation inhospitable for the existence of flora and fauna. The deterioration in soil health because of the mining activities is a matter of environmental concern for which it deserves priority for its reclamation. The investigation about the microbial community structure and its characterization provide greater understanding about the microbial activities and their contribution towards ecosystem functioning. In the present study, a mesophilic bacterium was isolated from fresh iron mine overburden spoil and identified through 16S rDNA sequence analysis. Microbial characterization revealed that the isolated bacterium was gram negative, obligatory and facultative chemolithotroph. The bacterium exhibited optimal growth at 37 o C in culture medium with pH 5, which suggested that the bacterium was mesophilic and acidophilic in nature. The growth response of the bacterium revealed relatively higher growth rate in heterotrophic condition as compared to chemolithotrohic culture condition. Molecular phylogenetic analysis based on 16S rDNA sequence homology suggested that the isolated bacterium exhibited closer resemblance with Ralstonia solanacearum NC_003296. 1 (100% sequence identity), which posses wide geographic distribution, large host range and the exceptional capacity to adapt in many different environments. Accepted:15 May 2016 Available Online: 06 June 2016
INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN CHEMISTRY AND PHARMACEUTICAL SCIENCES

The mechanism of prevention of bacterial growth by antibiotics is quite different from the mechanisms by which nanoparticles inhibit microbial growth. But in the present study effect of silver nanoparticles on the isolates from catheter and intra uterine devices biofilms was studied. Also invitro studies were carried out to find microbial biofilm formation on catheter tips and IUDs. Silver nanoparticles in aqueous solution were prepared by reduction of AgNO3 with NaBH4 and stabilized by using tri sodium citrate. The nanoparticles obtained hereby are stable for weeks. Microorganisms were isolated and were sub cultured in Muller Hinton broth for 24h at 37C. Wells of 6mm diameter were made on Muller Hinton agar plates using gel puncher. This study shows that the biofilm isolate P. mirabilis is very sensitivity to silver nanoparticles than standard antibiotics. The sensitivity of Neisseria gonnorrhaea to silver nanoparticles is little less. This can be seen from the diameter of zone of inhibition. So infections in patient with individually catheter and IUDs are difficult to treat with high dose of antibiotics. As silver nanoparticles even at a small dose inhibit the bacterial colonisation these particles can be coated on the devices to inhibitory bactericidal concentration.
INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN CHEMISTRY AND PHARMACEUTICAL SCIENCES

Influenza A virus H3N2 strain are simultaneously prevalent among human and bird population sometimes causing epidemic besides seasonal infections. This virus causes a substantial amount of morbidity and mortality in different parts of the world especially in the developing countries like Bangladesh. Although vaccine was developed against this virus strain, the activity of vaccine fails frequently due to accumulation of mutations in hemagglutinin (HA) gene. Here, we suggested an effective protein model with conserved epitope-based vaccine design which might be capable to neutralize that strain. After partial sequencing of HA gene of H3N2 isolated from Bangladeshi patients, we observed several mutations at different positions, some of which lies in existing epitopes or active sites which indicates possible resistance to existing vaccines, although experimental confirmation is needed. However, multiple sequence alignment with previously reported Bangladeshi and vaccine strains we have identified several conserved regions and some of these also fall in predicted and experimentally determined epitopes which may be useful for a new and potential vaccine development. We predicted a protein 3D model with the sequenced Bangladeshi H3N2 strain and identified conserved highly immunogenic epitopes and active sites in it which may be further evaluated experimentally for developing vaccine against it.
International Journal of Current Research in

Prunus africana is important for its bark used in the treatment of benign prostate hyperplasia in SouthWest Cameroon which has led to overexploitation of natural population of the species. Prunus africana is listed as an endangered species. Despite the relevance of bark, little information on the effects of some ecological and anthropic factors on the survival and bark recovery rate of Prunus africana is known. Debarking followed a combination of four factors: season of bark harvesting, three stem diameter classes and three intensities of trunk circumference debarked. After debarking, trees were trimestrially monitored for a two years period during which the survival of the tree and the speed of regeneration of the bark were recorded. Results show a dead rate of 13.33%. The rate of recovery of the bark at low altitude was about 21.27 cm/year. The best season for debarking was the rainy season (27.49 cm/year). Trees with a weak diameter (20-30 cm) showed a low rate of recovery (18.28 cm/year) and also those whose bark were peeled on a surface of 75 % of the tree’s diameter (29.09 cm/year). These factors have important implications in drawing strategies for sustainable harvesting, management and conservation of this species. Accepted: 08 July 2016 Available Online: 06 August 2016
International Journal of Current Research in

Root hair is tubular projections from the root epidermal cell. In general, root-hair formation results in a significant increase in root surface area, which plays the important roles in nutrients and water uptake, plant anchorage, and interaction with soil microorganisms. In this paper, we discussed the effects of nitrogen, phosphorus, potassium, calcium, iron, and magnesium on root hair growth and their relevant mechanisms. Interaction exists between nutrients and phytohormones on root hair growth has also been discussion. As a result, more works are needed to clone the genes of additional root hair mutants and elucidate their roles, as well as undertaking reverse genetics and mutant complementation studies to add the current knowledge of the signaling networks, which are involved in root hair cell fate specification, initiation, tip growth and maturation regulated by nutrients. Accepted: 30 November 2017 Available Online: 06 December 2017