Miracle-dz/UniFAR-FTUs huggingface dataset:
Long time stability of regularized PML wave equations

—In this paper, we consider two dimensional acoustic wave equations in an unbounded domain and introduce a modiﬁed model of the classical perfectly matched layer (PML). In the classical PML model, an unexpected and exponential increase in energy is observed in the long-time simulation after the solution reaches a quiescent state. To address such an instability, we provide a regularization technique to a lower order regularity term employed in the auxiliary variable in the classical PML model. The well-posedness of the regularized system is analyzed with the standard Galerkin method based on the energy analysis, and the numerical stability of staggered ﬁnite difference method for its discretization is provided by using von Neumann stability analysis. To support the theoretical results, under various thickness and damping values, we demonstrate a long-time stability of acoustic waves in the computational domain.
EFFECTS OF MANNAN OLIGOSACCHARIDES AS A DIETARY SUPPLEMENT ON PERFORMANCE AND CARCASS CHARACTERISTICS OF JAPANESE QUAILS (COTURNIX

The effect of three levels of mannan oligosaccharides (MOS) as a dietary supplement on growth performance, carcass characteristics and some blood metabolites of growing Japanese quails ( Coturnix japonica ) was the main objective of this experiment. A total of one hundred 1-day-old Japanese quails were randomly divided into 4 experimental groups (25 birds/ each treatment) with 3 replicates (8 birds in two replicates and 9 birds in one replicate). The experimental groups consisted of four dietary treatments: 1) a control basal diet without supplementation; 2) a basal diet with a MOS at level of 1 g/kg feed (low MOS); 3) a diet with MOS at a level of 3 g/kg feed (medium MOS); and 4) a diet with a MOS at a level of 5 g/kg feed (high MOS). The experimental period extended for 42 days. The data revealed that, birds fed diets containing medium MOS level (3 g /kg feed) recorded significant ( P < 0.05) improvements in body weight, weight gain, feed conversion efficiency, performance index, energy and protein efficiency compared with those fed the control one, low and high levels of MOS. Also medium level of MOS supplementation increased the dressing percentage and edible giblets, while the offal's percentages and carcass abdominal fat were significantly decreased. Growth performance was significantly improved at 3 g MOS/ kg diet, however high dosage of MOS have negative effects on growth rate of the birds. The triglyceride, total cholesterol and total lipids concentrations in quails blood decreased significantly in concomitant with a significant decrease in carcass fat % as a response to dietary MOS supplementation. From the results of the current study, it could be concluded that the responses of Japanese quails to MOS are influenced by the level of its supplementation in the diet. Therefore, this factor needs to be carefully considered in order to obtain maximal growth-promoting effects of MOS in Japanese quail production. __________________________________________________________________________________________
Incorporation of [14CJGlucose into Cell Wall Polysaccharides of Cotton Roots: Effects of NaCl and CaCl21

Cotton (Gossypium hirsutum L. cv Acala SJ-2) seedlings were grown in nutrient solutions with four combinations of NaCI (0.1 and 150 millimolar) and CaC12 (1 and 10 millimolar) for 7 days, and then exposed to [14Cjglucose for 5 hours. Uptake and incorporation of j'4Clglucose into various cell wall fractions of the root tips were determined. At 1 millimolar Ca2 , treatment with 150 millimolar NaCl slightly stimulated uptake but considerably inhibited glucose incorporation into noncellulosic and cellulosic polysaccharides. Supplemental Ca2' did not affect incorporation of glucose into the noncellulosic fraction (regardless of NaCl treatment) but completely alleviated the inhibitory effect of NaCI on glucose incorporation into cellulose. We suggest that high Na' concen- trations reduce synthesis of cellulose in cotton roots via disturbance of plasma membrane integrity and that supplemental Ca2" counteracts this effect. The effects on cellulose biosynthesis are proposed to be related to Ca2' displacement from the plasma membrane.
Bayesian and Frequentist: An Example

In order to show the differences between the bayesian and frequentist inference let us solve the same problem with the two approaches. Let us suppose that we want to find the probability of a swan to be black since we have observed just white swans. The probability of a swan to be black, can be modeled as a Bernoulli random variable where the probability of success (probability of a swan to be black) is P ∈ [0, 1] and the observed probability (the number of black swan s that we have observed out of a total of n observations) is ̂ P ∈ [0, 1]. In the bayesian perspective the parameter P is not fixed but has an unknown probability distribution and, before observing ̂ P , we have to encapsulate our prior belief about P in the prior distribution. Since to do not have any prior information abut P we use an uninformative prior which assigns equal probabilities to all possibilities:
An exploration of the role of intuitive forms of planning in the succession process: the explanatory power of effectuation theory

Purpose – This study explores how and when intuitive forms of planning can be used in a family firm ’ s succession process. Design/methodology/approach – The study uses an extended focus group meeting, consisting of individual, group and subgroup discussions with seven highly experienced external family business advisors in the Netherlands to gain a holistic understanding of the succession process and its underlying logic. The study also employs pre- and post-group questionnaires. Findings – This study reveals that advisors perceive intuitive forms of planning as an integral part of the successionprocess,withthelattercontainingbothintuitiveandformallogicandactivities.Bothlogicsareusedsituationallyandflexiblytodealwiththeuniquenessandunpredictabilityofthesuccessionprocessandtobuildstrongrelationsandmanagerelationaldynamicsinbusinessfamiliestoaddresstasks,dilemmasandcontingencies. Originality/value – The succession process is an important part of business families ’ achievement of transgenerationalintent.Creatingcommitmentamongpotentialsuccessorsbeginswhentheyarechildren,andunderstandingtheroleofthemoreintuitiveformsofplanningduringthesuccessionprocesswillprovideus with a more holistic perspective on its dynamics.
Novel endpoints for clinical trials in young children with cystic fibrosis

Cystic fibrosis (CF) is a disease caused by mutation in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Although CF is a multi-system disorder, progressive lung disease is the most common cause of mortality. Decline in lung function is largely a result of structural lung damage associated with neutrophil-dominated inflammation and chronic pulmonary infections (1). Evidence of structural lung disease on chest computed tomography (CT), pulmonary inflammation and endobronchial infection (2, 3) (4) have all been reported in the first months of life in infants diagnosed with CF following newborn screening (NBS), and often in the absence of respiratory symptoms (5, 6). However, lung function is reported to be within normal limits for the majority of young infants diagnosed by (7–9), indicating a critical window of opportunity for intervention. While many new and exciting CF disease modifying agents are undergoing clinical trial evaluation (see (10) for review), including CFTR potentiators and correctors, clinical trials are difficult in patients younger than 5 years due a lack of age-appropriate clinical trial endpoints (ref 1. Davis SD, Brody AS, Emond MJ, Brumback LC, Rosenfeld M. Endpoints for clinical trials in young children with cystic fibrosis. Proc Am Thorac Soc. 2007 Aug 1;4(4):418–30). This population, with less severe lung damage, are most likely to benefit from intervention with disease-modifying therapies and implementation of such therapies in infancy has the potential to change the prognosis for CF patients. As such, methods to assess early lung disease with the potential to serve as outcome measures for clinical trials are urgently needed. The increased emphasis on the detection and treatment of early CF lung disease over recent years (11) has driven the need for the development of sensitive, reproducible, and feasible outcome measures for quantifying mild lung disease in young children with CF, including advancements in infant and preschool lung function testing,
Nitric Oxide Synthase-Dependent Nitric Oxide Production Is Associated with Salt Tolerance in Arabidopsis 1[OA]

Nitric oxide (NO) has emerged as a key molecule involved in many physiological processes in plants. To characterize roles of NO in tolerance of Arabidopsis ( Arabidopsis thaliana ) to salt stress, effect of NaCl on Arabidopsis wild-type and mutant ( Atnoa1 ) plants with an impaired in vivo NO synthase (NOS) activity and a reduced endogenous NO level was investigated. Atnoa1 mutant plants displayed a greater Na 1 to K 1 ratio in shoots than wild-type plants due to enhanced accumulation of Na 1 and reduced accumulation of K 1 when exposed to NaCl. Germination of Atnoa1 seeds was more sensitive to NaCl than that of wild-type seeds, and wild-type plants exhibited higher survival rates than Atnoa1 plants when grown under salt stress. Atnoa1 plants had higher levels of hydrogen peroxide than wild-type plants under both control and salt stress, suggesting that Atnoa1 is more vulnerable to salt and oxidative stress than wild-type plants. Treatments of wild-type plants with NOS inhibitor and NO scavenger reduced endogenous NO levels and enhanced NaCl-induced increase in Na 1 to K 1 ratio. Exposure of wild-type plants to NaCl inhibited NOS activity and reduced quantity of NOA1 protein, leading to a decrease in endogenous NO levels measured by NO-speciﬁc ﬂuorescent probe. Treatment of Atnoa1 plants with NO donor sodium nitroprusside attenuated the NaCl-induced increase in Na 1 to K 1 ratio. Therefore, these ﬁndings provide direct evidence to support that disruption of NOS-dependent NO production is associated with salt tolerance in Arabidopsis. The composed of 0.1 buffer, 3-methyl-2-benzothiazo-line hydrazone, and 0.3 The reaction was initiated by addition of 200 m L sample. The absorbance change at 590 nm was monitored at 25 (cid:3)
Stroke Unit Design: Intensive Monitoring Should Be a Routine Procedure Controversies in Stroke

here are compelling parallels between the management of patients with acute stroke and acute myocardial infarction. Common themes include the importance of organized expert care, the value of acute reperfusion strategies in selected patients, and the application of similar early secondary prevention therapies. In both conditions, physiological parameters such as blood pressure, oxygena-tion, and glycemic status are thought to be important. How-ever, coronary care units (CCUs) were high-technology monitoring units from the outset in the late1960s, while stroke care units (SCUs) have in most cases consisted of low-technology care, where stroke patients are treated by a multidisciplinary team in a geographically specific location.
Noise Evaluation Technique Based on Surface Pressure

max. 2000 char. ): This document summarizes the scientific results achieved during the EUDP-funded project `Low-Noise Airfoil'. The goals of this project are, on one side to develop a measurement technique that permits the evaluation of trailing edge noise in a classical aerodynamic wind tunnel, and on the other side to develop and implement a design procedure to manufacture airfoil profiles with low noise emission. The project involved two experimental campaigns: one in the LM Wind Power wind tunnel, a classical aerodynamic wind tunnel, in Lunderskov (DK), the second one in the Virginia Tech Stability Wind Tunnel at the Aerospace and Ocean Engineering Department of Virginia Tech (Blacksburg, VA, USA), also a classical aerodynamic wind tunnel but equipped with an anechoic chamber that allow to perform acoustic measurements. On the theoretical side, the above experiments yield a series of model validations and improvements. In particular, the so-called TNO trailing edge noise model could be significantly improved by introducing turbulence anisotropy in its formulation, as well as the influence of the boundary layer mean pressure gradient. This two characteristics are inherent to airfoil flows but were neglected in the original approach. In addition, the experimental results are confronted to detailed Large Eddy Simulations of the airfoil flow giving more insight into the flow turbulence characteristics. The methodology which consists in measuring surface pressure spectra directly on the airfoil surface using flush-mounted microphones in order to evaluate far-field noise emission using additional theoretical results has been validated. This technique presents the advantage that it can easily be used in a classical aerodynamic wind tunnel and does not require the use of an anechoic facility. It was developed as a substitute to the original plan that consisted in measuring acoustic waves using hot-wire velocimetry. This last technique proved ineffective in the LM Wind Tunnel as the high ambient noise levels largely overwhelmed the signal of interest. Finally, a new airfoil design was proposed based on a design concept including noise reduction. The new airfoil proved to perform better aerodynamically but noise reduction were not as important as expected, mainly due to the inaccuracy of the simplified flow model used in the design algorithm. ISBN 978-87-92896-03-2 EAN 9788792896032 Contract no.: EUDP Jr. Nr. 64009-0272 Project no.: PSP-Elt. 1110076 Sponsorship: EUDP-2009-II Project: `Low Noise Airfoil Design and Validation’
EFEMP2 Inhibits Breast Cancer Invasion And Metastasis In Vitro And In Vivo

Background: EGF-containing ﬁ bulin-like extracellular matrix protein 2 (EFEMP2) is an extracellular matrix (ECM) glycoprotein, which is regarded as potential prognostic biomar-kers in some carcinoma. Little is known about the association of EFEMP2 and breast cancer. Methods: EFEMP2 expressions in normal breast tissue, benign ﬁ broadenoma, breast cancer, the normal mammary epithelial cell line, and 4 different invasive breast cancer cell lines were evaluated by immunohistochemistry (IHC) or immunocytochemistry (ICC) and real time quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR). Expression and prognostic value of EFEMP2 in breast cancer were veri ﬁ ed by the Public databases (Oncomine and Kaplan-Meier plotter database). Lentiviral vector with EFEMP2 cDNA was constructed and used to infect breast cancer cell lines to investigate the effects of EFEMP2 on the biological behavior of breast cancer cells by functional in vitro and in vivo assays. Results: Down-regulated EFEMP2 expression was found in breast cancer tissues and cells, and low expression of EFEMP2 was associated with poor prognosis in patients with breast cancer. Analysis by the Public database leaded to the same conclusion. Up-regulated EFEMP2 expression signi ﬁ cantly hampered the invasion and metastasis abilities of breast cancer cells and the process of epithelial interstitial transformation (EMT) via the Wnt/ β catenin pathway. Conclusion: EFEMP2 expression was lower in breast cancer and closely related to the prognosis of patients, its anti-oncogenic roles indicated the underlying therapeutic target for the future treatment of breast cancer.
“FORMULATION AND EVALUATION OF AN ANTIMICROBIAL DRUG LOADED HYDROGEL MATRIX TABLETS FOR CONTROLLED DRUG DELIVERY”

The objective of present study was to prepare Ciprofloxacin Hydrochloride (CPH) loaded controlled release matrix tablets using a new polymer combination of Methyl cellulose A4 and Polyox WSR 303 in varying ratios by direct compression technique. Differential Scanning Calorimetry (DSC) measurements were carried out on the drug polymer mix and pure polymers Methyl cellulose A4 and Polyox WSR 303. A 3 2 Full Factorial design was employed to optimize the matrix tablet formulation of Ciprofloxacin Hydrochloride (CPH) by selecting amount of Methyl Cellulose and Polyox WSR 303 as independent variables and their effects were observed on T 50 , T 90 , and % Swelling index. The optimized batch was examined for in-vitro drug release and pharmacokinetics in animals. The antimicrobial activity against B. subtilis and E. coli was determined. The optimized batch gave desired results at 5 hrs as time for 50% drug release at 23 hrs as time for 90% drug release and % swelling index as 45%. The kinetic model fitting of the optimized batch showed Weibull distribution as mechanism of drug release having 0.966 R 2 value for CPH from the matrix tablet.Pharmacokinetics (Non- compartmental analysis) in animals revealed C max = 3.08 μg/mL, T max = 6hr, AUC 24 = 45.18 μg/mL*hr, MRT = 21.93 μg/mL*hr, T 1/2 = 13.4 hr and K e = 0.0154 -1 . Compartmental analysis showed as per the following K a = 0.64 -1 , T max = 4.36hr, AUC 24 = 45.63 μg/mL*hr, MRT = 19.58 μg/mL*hr, T 1/2 = 1.15hr and K e = 0.64 -1 .
Hsp90α Is Suitable for Therapy Monitoring in Multiple Cancers

Min Fu Department of Oncology, Nanyang Second People's Hospital, Nanyang, Henan 473000 Feng Du Department of Oncology, Nanyang Second People's Hospital, Nanyang, Henan 473000 Zhe Wei Department of Oncology, Nanyang Second People's Hospital, Nanyang, Henan 473000 Cheng Xu Biotecan Medical Diagnostics Co., Ltd, Zhangjiang Center for Translational Medicine, Shanghai, 201204 Xinjun Wang (  xjwang16@fudan.edu.cn ) Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai Xiaoyu Zhao State Key Laboratory of Genetic Engineerings, School of Life Sciences, Fudan University, Shanghai, 200433
Comparison of shaping ability of the Reciproc Blue and One Curve with or without glide path in simulated S-shaped root canals

Objectives This study aimed to assess the impact of a glide-path on the shaping ability of 2 single-file instruments and to compare the centering ability, maintenance of original canal curvatures and area of instrumentation in simulated S-shaped root canals. Materials and Methods Forty simulated S-shaped root canals were used and were prepared with One Curve (group OC), One G and OC (group GOC), Reciproc Blue (group RB) and R-Pilot and RB (group PRB) and scanned before and after instrumentation. The images were analyzed using AutoCAD. After superimposing the samples, 4 levels (D1, D2, D3, and D4) and 2 angles (Δ1 and Δ2) were established to evaluate the centering ability and modification of the canal curvatures. Then, the area of instrumentation (ΔA) was measured. The data were analyzed using 2-way analysis of variance and Tukey's test for multiple comparisons (p < 0.05). Results Regarding the centering ability in the apical part (D3, D4), the use of the glide-path yielded better results than the single-file groups. Among the groups at D4, OC showed the worst results (p < 0.05). The OC system removed less material (ΔA) than the RB system, and for Δ1, OC yielded a worse result than RB (p < 0.05). Conclusions The glide-path improved the centering ability in the apical part of the simulated S-shaped canals. The RB system showed a better centering ability in the apical part and major respect of the canal curvatures compared with OC system.
Floer cohomology of g -equivariant Lagrangian branes

Building on Seidel-Solomon’s fundamental work [36], we deﬁne the notion of a g equivariant Lagrangian brane in an exact symplectic manifold M where g ⊂ SH 1 ( M ) is a sub-Lie algebra of the symplectic cohomology of M . When M is a (symplectic) mirror to an (algebraic) homogeneous space G / P , homological mirror symmetry predicts that there is an embedding of g in SH 1 ( M ). This allows us to study a mirror theory to classical constructions of Borel-Weil and Bott. We give explicit computations recovering all ﬁnite dimensional irreducible representations of sl 2 as representations on the Floer cohomology of an sl 2 -equivariant Lagrangian brane and discuss generalizations to arbitrary ﬁnite-dimensional semisimple Lie algebras.
Clinical Auditing of Patient Safety Standards Before and After Implementation of the Training Program in Intensive Care Units

Introduction: Patient safety is the precious core in the healthcare organizations aimed at minimizing adverse events and eliminating preventable damages. This study aimed at determining the rate of observation of safety standards of ICU patients by nurses before and after implementation of a training program. Methods: This quasi-experimental single-group study was conducted in two phases: observation of nursing performance related to patient safety and the implementation of a corrective training program. In the first phase, 4104 cases of nursing care related to patient safety performed by 54 ICU nurses were observed using chronological sampling. The same samples, i.e., 4104 nursing care performed by the same nurses, were used in the second phase of the study after implementing the training program. The data collection instrument was a valid and reliable researcher-made 76-item questionnaire consisting of 12 categories about nursing care related to patient safety. The corrective training program focused on nursing care related to patient safety. The gleaned data were analyzed with SPSS18 using descriptive statistics and nonparametric Wilcoxon signed-rank tests. Results: The rate of correspondence between nursing care and the checklist was 44.32 % before the intervention, which increased to 95.61% after intervention by a 51.29% increase. Conclusions: Implementation of the corrective intervention effectively promotes patient safety as a training program for nurses. The healthcare system's managers and authorities can reduce the damages sustained by patients and decrease treatment costs by concentrating on periodic supervision and continuous education programs to improve patient safety.