Miracle-dz/UniFAR-FTUs huggingface dataset:
Rotavirus in a Gnotobiotic Pig Model Alters Innate Immune Responses to Human Prenatally Acquired Vitamin A Deficiency

We examined how prenatally acquired vitamin A deﬁciency (VAD) modulates innate immune responses and human rotavirus (HRV) vaccine efﬁcacy in a gnotobiotic (Gn) piglet model of HRV diarrhea. The VAD and vitamin A–sufﬁcient (VAS) Gn pigs were vaccinated with attenuated HRV (AttHRV) with or without concurrent oral vitamin A supplementation (100,000 IU) and challenged with virulent HRV (VirHRV). Regardless of vaccination status, the numbers of conventional and plasmacytoid dendritic cells (cDCs and pDCs) were higher in VAD piglets prechallenge, but decreased substantially postchallenge as compared with VAS pigs. We observed signiﬁcantly higher frequency of CD103 (integrin a E b 7 ) expressing DCs in VAS versus VAD piglets postchallenge, indicating that VAD may interfere with homing (including intestinal) phenotype acquisition. Post-VirHRV challenge, we observed longer and more pronounced diarrhea and higher VirHRV fecal titers in nonvaccinated VAD piglets. Consistent with higher VirHRV shedding titers, higher IFN- a levels were induced in control VAD versus VAS piglet sera at postchallenge day 2. Ex vivo HRV-stimulated mononuclear cells (MNCs) isolated from spleen and blood of VAD pigs prechallenge also produced more IFN- a . In contrast, at postchallenge day 10, we observed reduced IFN- a levels in VAD pigs that coincided with decreased TLR3 + MNC frequencies. Numbers of necrotic MNCs were higher in VAD pigs in spleen (coincident with splenomegaly in other VAD animals) prechallenge and intestinal
ULTRAVIOLET IRRADIATION TO ENRICH FOODS WITH VITAMIN D

g/g (640-940 µ g/g), which increases its initial concentration (less than 20 IU of vitamin D 2 /100 g) almost 30-50-fold (EFSA, 2014). The vitamin D 2 -enriched UV-treated yeast is allowed by The European Food Safety Authority (EFSA) for fortification of yeast-leavened bread, rolls and fine pastry at maximum D 2 dose of 5 μ g per 100 g of the products. The concentration of vitamins D 2 and D 3 after UV irradiating of the wheat germ oil (1.6 mm oil layer) was 1035 and 37 ng/g, respectively (A.C. Baur et al., 2016). Similarly, there is an increase of the vitamin D content in eggs after exposure of chickens to UV irradiation or natural sunlight (A. Schutkowski et al., 2013; J. K ü hn et al., 2014, 2015). In the conditions of the complete absence of the commercial production of vitamins in our country, bio-addition with vitamin D of chicken meat, eggs and dairy products by UV irradiation of animals, mushrooms, yeast, vegetable oils takes on particular significance.
AN ANALYSIS OF THE DENOTATIONS OF "PROGRAM" AS EMPLOYED IN ORDINARY LANGUAGE AN ADULT EDUCATION DISCOURSE, WITH ' A TYPOLOGY OF,TROGRNM BASED ON THE DENOTATIONS

'DESCRIPTORS -*Adult EduOation; Adult. Educators; *Componential Analysis; Context.Clues; Language Patterns; *SemanticstSpeeches;'*Typology ". ,--. /: °N. ,,, ABSTRACT Thisitudy attempted to clarify the concept ',program', by systematically examining the -Ube of the term "program. " The term was examined as it is used. in ordinary language and in adult education literature. After analysis. of. the term within these ! two contexts, a typology was developed from the uses identified. The . ' typology was then,utilized as an . aid in determining those variables affecting the validity' of propositionS, containing the term flprogramu or concepts referred to in the use of te term. The:iesults.indicated 4: that there were five. senses Of uprogr' en that is,,,,system, plan, , document, performance, and planning. Th implications that these results. have for the. -`adult eduCator are noted. They are: (1) the term "program" should be explicitly-defined if it iszto be used as a 1/
The formation of stoichiometric uranium brannerite (UTi

Brannerite glass-ceramic composites have been suggested as suitable wasteform materials for highactinide content wastes, but the formation of glass-ceramic composites containing stoichiometric uranium brannerite (UTi 2 O 6 ) has not been well-studied. Uranium brannerite glass-ceramic composites were synthesised at by a one-pot cold-press and sinter route from the component oxides. As a comparison, two further samples were produced using an alkoxide-nitrate route. A range of compositions with varying molar ratios of uranium and titanium oxides (from 1:2 to 1:3.20) were synthesised, with a range of different heat treatments (1200 °C for 12–48 h, and 1250 °C for 12 h). All compositions were analysed by X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, and X-ray nearedge spectroscopy, and found to contain UTi 2 O 6 as the majority crystalline phase forming within a glass matrix of nominal stoichiometry Na 2 AlBSi 6 O 16 . In compositions with UO 2 :TiO 2 ratios of 1:2 and 1:2.28, particles of UO 2 were observed in the glass matrix, likely due to dissolution of TiO 2 in the glass phase; this was prevented by the addition of excess TiO 2 . This work demonstrates the suitability of this system to produce highly durable wasteforms with excellent actinide waste loading, even with a simple one-pot process. Some grains of brannerite consist of a UO 2 particle encapsulated in a shell of UTi 2 O 6 , suggesting that brannerite crystallises around particles of UO 2 until either the UO 2 is fully depleted, or the kinetic barrier becomes too large for further diffusion to occur. We propose that the formation of brannerite within glass-ceramic composites at lower temperatures than that for pure ceramic brannerite is caused by an increase in the rate of diffusion of the reactants within the glass. © 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )
Effects of bevel direction of endotracheal tube on the postoperative sore throat when performing fiberoptic‐guided tracheal intubation: A randomized controlled trial

Background: During fiberoptic-guided tracheal intubation, impingement between the distal tip of the endotracheal tube and the airway tissue can cause difficulties in tube insertion or tissue damage during the tube advancement over the bronchoscope. This randomized controlled study aimed to investigate the effects of the endotracheal tube’s bevel direction on the complications associated with airway injury when performing fiberoptic-guided tracheal intubation. Methods: The study subjects were divided into 2 groups: L (control) and D (study). When advancing the tube over the bronchoscope, the tube’s bevel was facing the patients’ left in Group L and the dorsal direction in Group D. According to the degree of resistance at the time of tube advancement, the insertion score was graded in 3 stages; the severity of the patients’ sore throat and hoarseness was evaluated and recorded postoperatively. Results: The severity of postoperative sore throat was higher in Group L than in Group D 3 hours and 24 hours after surgery. (P = .008, P = .023, respectively). The tube insertion score was comparable between the groups. The severity of postoperative hoarseness did not vary significantly between the groups. Conclusion: Endotracheal tube insertion with the bevel facing the dorsal direction of the patient during fiberoptic-guided tracheal intubation reduced the severity of postoperative sore throat in patients undergoing laparoscopic gynecologic surgery.
Adaptive MPC Model Selection via Machine Learning

This report details the development of a novel approach to improve the robustness 1 of model predicative control, MPC, schemes using machine learning. Several 2 MPC systems are simulated with different underlying process models to generate 3 training data that is used to train a support vector machine, a support vector machine 4 regressor, and 2 multilayer perceptrons. These trained machine learning techniques 5 are used to rectify simulated MPC model mismatch. Results provide evidence that 6 these machine learning methods, particularly support vector machines and support 7 vector regressors, can be used to dynamically select an appropriate MPC model 8 given a system’s response. Also a brief overview of model predictive control is 9 provided for readers without a control background.
Relative Ef ﬁ cacy of AS03-Adjuvanted Pandemic In ﬂ uenza A(H1N1) Vaccine in Children: Results of a Controlled, Randomized Ef ﬁ cacy Trial

Background . The vaccine ef ﬁ cacy (VE) of 1 or 2 doses of AS03-adjuvanted in ﬂ uenza A(H1N1) vaccine relative to that of 2 doses of nonadjuvanted in ﬂ uenza A(H1N1) vaccine in children 6 months to <10 years of age in a mul-tinational study conducted during 2010 – 2011. Methods . A total of 6145 children were randomly assigned at a ratio of 1:1:1 to receive 2 injections 21 days apart of A/California/7/2009(H1N1)-AS03 vaccine at dose 1 and saline placebo at dose 2, 2 doses 21 days apart of A/California/7/2009(H1N1)-AS03 vaccine (the Ad2 group), or 2 doses 21 days apart of nonadjuvanted A/Cali-fornia/7/2009(H1N1) vaccine (the NAd2 group). Active surveillance for in ﬂ uenza-like illnesses continued from days 14 to 385. Nose and throat samples obtained during in ﬂ uenza-like illnesses were tested for A/California/7/2009 (H1N1), using reverse-transcriptase polymerase chain reaction. Immunogenicity, reactogenicity, and safety were assessed. Results . There were 23 cases of con ﬁ rmed 2009 pandemic in ﬂ uenza A(H1N1) (A[H1N1]pdm09) infection for the primary relative VE analysis. The VE in the Ad2 group relative to that in the NAd2 group was 76.8% (95% con- ﬁ dence interval, 18.5% – 93.4%). The bene ﬁ t of the AS03 adjuvant was demonstrated in terms of the greater immunogenicity observed in the Ad2 group, compared with the NAd2 group. Conclusion . The 4 – 8-fold antigen-sparing adjuvanted pandemic in ﬂ uenza vaccine demonstrated superior and clinically important prevention of A(H1N1)pdm09 infection, compared with nonadjuvanted vaccine, with no observed increase in medically attended or serious adverse events. These data support the use of adjuvanted in ﬂ uenza vaccines during in ﬂ uenza pandemics.
Effects Of Mechanical In-Exsu ation On Mucus Clearance In Critically Ill Patients On Invasive Mechanical Ventilation

Roberto Martinez-Alejos (  rober.martinez.alejos@gmail.com ) Centre Hospitalier Regional Universitaire de Montpellier https://orcid.org/0000-0002-2444-0575 Joan-Daniel Martí Hospital Clinic de Barcelona Gianluigi Li Bassi Queensland University of Technology Daniel Gonzalez-Anton Centre Hospitalier Universitaire de Bordeaux Xabier Pilar-Diaz Centre Hospitalier Universitaire de Bordeaux Thomas Reginault Centre Hospitalier Universitaire de Bordeaux Philippe Wibart Centre Hospitalier Universitaire de Bordeaux Albert Gabarrus Hospital Clinic de Barcelona Alice Quinart Centre Hospitalier Universitaire de Bordeaux Antoni Torres Hospital Clinic de Barcelona
Helper-Dependent Adenoviral Vector-Mediated Delivery of Woodchuck-Speciﬁc Genes for Alpha Interferon (IFN- (cid:2) ) and IFN- (cid:3) : IFN- (cid:2) but Not IFN- (cid:3) Reduces Woodchuck Hepatitis Virus Replication in Chronic Infection In Vivo

Alpha interferon (IFN- (cid:1) ) and IFN- (cid:2) are able to suppress hepadnavirus replication. The intrahepatic expression of high levels of IFN may enhance the antiviral activity. We investigated the effects of woodchuck- speciﬁc IFN- (cid:1) (wIFN- (cid:1) ) and IFN- (cid:2) (wIFN- (cid:2) ) on woodchuck hepatitis virus (WHV) replication in vivo by helper-dependent adenoviral (HD-Ad) vector-mediated gene transfer. The expression of biologically active IFNs was demonstrated in vitro after transduction of woodchuck cells with HD-Ad vectors encoding wIFN- (cid:1) (HD-AdwIFN- (cid:1) ) or wIFN- (cid:2) (HD-AdwIFN- (cid:2) ). The transduction efﬁcacy of the HD-Ad vector in woodchuck liver in vivo was tested with a vector expressing green ﬂuorescence protein (GFP). Immunohistochemical staining of liver samples on day 5 after injection showed expression of GFP in a high percentage of liver cells surrounding the central vein. The transduction of livers of WHV carriers in vivo with HD-AdwIFN- (cid:1) or HD-AdwIFN- (cid:2) induced levels of biologically active IFN, which could be measured in the sera of these animals. Expression of wIFN- (cid:1) in the liver reduced intrahepatic WHV replication and WHV DNA in sera of about 1 log step in two of two woodchucks. Transduction with HD-AdwIFN- (cid:2) , however, reduced WHV replicative intermediates only slightly in two of three animals, which was not accompanied with signiﬁcant changes in the WHV DNA in sera. We demonstrated for the ﬁrst time the successful HD-Ad vector-mediated transfer of genes for IFN- (cid:1) and IFN- (cid:2) in vivo and timely limited reduction of WHV replication by wIFN- (cid:1) , but not by wIFN- (cid:2) .
Green Synthesis of TiO 2 Nanoparticles and Study of Impedance Spectroscopy of TiO 2 -Polypyrrole Nanocomposites

Nanotechnology is a new star in the science horizon with many valuable applications and promises to offer. It includes the synthesis and utilization of nanostructure materials ranging from 1 to 100 nm. Mostly these materials are generally (or “could be”) p roduced via the laborious and hazard-prone physical and chemical methods but the green synthesis approaches easier, safe and scalable have been recently developed. Among other metal oxides nanoparticles, Titanium oxide (TiO 2 ) nanoparticles have been mostly exploited for their photocatalytic, antimicrobial and antiparasitic applications. Titanium dioxide nanoparticles (TiO 2 -NPs) were synthesized using the aqueous leaf extract of Aloe barbadensis as a reducing and fabricating agent. Based on the HRTEM and FESEM analysis, X-ray diffraction (XRD), the biosynthesized NPs were found to be polydispersed and predominantly spherical in shape, with an average size of ~20 nm. Complex impedance and dielectric permittivity of TiO 2 -PPY nanocomposite have been investigated as a function of frequency and temperature at different compositions. The dielectric permittivity 2500 is observed. Large value of permittivity is well described by Maxwell-Wagner polarization. Broad and asymmetric dielectric spectra are analyzed by Harviliak - Nigami relaxation function.
Psychometric Evaluation of Knowledge Sharing Behavior Scale in Academic Environment

This study examined the psychometric properties of the Knowledge Sharing Behavior Scale (KSBS) using academicians at the University of Sargodha, Sargodha. The quantitative research design was adopted using a survey questionnaire to collect data from academicians. A 28-item KSBS was administered to 300 academicians, recruited through the convenient stratified process by visiting each department with permission. The researchers received 237 usable questionnaires indicating a response rate. The validity (e.g., construct validity, convergent validity, and discriminant validity) and reliability (e.g., internal consistency measure Cronbach Alpha) of the instrument was examined using partial least square structural equation modeling with SmartPLS. The results indicated that KSBS is not a valid measure for assessing knowledge sharing behavior in an academic context, specifically in the Pakistani environment. These results suggested the need for more investigation examining psychometric evaluation of KSBS in academic and other contexts before generalization of these results. This research would make an invaluable contribution to the existing research on knowledge sharing in general and knowledge sharing behavior in particular, as only a few such studies are available so far.
An evolutionary algorithm for graph planarisation by vertex deletion. In: 16th International Conference on Enterprise Information Systems (ICEIS

: A non-planar graph can only be planarised if it is structurally modiﬁed. This work presents a new heuristic algorithm that uses vertices deletion to modify a non-planar graph in order to obtain a planar subgraph. The proposed algorithm aims to delete a minimum number of vertices to achieve its goal. The vertex deletion number of a graph G = ( V , E ) is the smallest integer k ≥ 0 such that there is an induced planar subgraph of G obtained by the removal of k vertices of G . Considering that the corresponding decision problem is NP-complete and an approximation algorithm for graph planarisation by vertices deletion does not exist, this work proposes an evolutionary algorithm that uses a constructive heuristic algorithm to planarise a graph. This constructive heuristic has time complexity of O ( n + m ) , where m = | V | and n = | E | , and it is based on the PQ -trees data structure and on the vertex deletion operation. The algorithm performance is veriﬁed by means of case studies.
Kinerja Energy Detection Spectrum Sensing untuk Cognitive Radio Menggunakan GNU Radio

spectrum spectrum sensing ( energy ) Radio. estimasi power spectral density (PSD) periodogram blok Embedded Python pada GNU Radio. Selanjutnya, modul spectrum sensing decision pada GNU Radio diimplementasikan. Modul ini membandingkan estimasi PSD isyarat PU yang terkena derau dengan sebuah threshold . Isyarat PU disimulasikan sebagai proses acak bandpass yang menempati pita frekuensi tertentu. Modul spectrum sensing decision dikembangkan untuk memungkinkan perhitungan probability of detection (PD) dan probability of false alarm (PFA) yang dilakukan dengan memanfaatkan blok Embedded Python . Salah satu indikator untuk mengevaluasi kinerja modul spectrum sensing adalah kurva receiver operating characteristic (ROC) berdasarkan hasil perhitungan PD dan PFA pada GNU Radio. Kemudian, kinerja spectrum sensing untuk SNR dan threshold yang berbeda-beda dihitung. Hasil menunjukkan bahwa spectrum sensing berbasis deteksi energi mampu menemukan keberadaan PU bila signal-to-noise ratio (SNR) cukup tinggi.
2 Millimeter Observations of Bright-rimmed Clouds with IRAS Point Sources

We have made 2 mm continuum observations of 15 bright-rimmed clouds (BRCs) associated with IRAS point sources and S140 with the Nobeyama Bolometer Array (NOBA) mounted on the 45 m telescope of Nobeyama Radio Observatory. Continuum emission was detected in five BRCs and in S140. These five BRCs are known to be associated with near-infrared YSO clusters, mostly on the side facing toward the exciting star(s) and, therefore, are likely the sites of small-scale sequential star formation. The detected emission peaks of these five sources correspond to the IRAS positions within the positional errors, and the IRAS sources are considered to be protostars (Class 0/I-like sources) that were formed most recently in the BRCs. Four of them are clearly extended more than the telescope beam, suggesting the presence of circumstellar structures. The circumstellar masses derived from the 2 mm continuum are ∼5–90 M⊙, which are more massive than those of the nearby Class 0/I objects (≲1 M⊙). This fact and the relatively large bolometric luminosities of these objects suggest that the mass of the cluster or star(s) most recently formed in these BRCs could be higher than those of the previously formed stars found in the near-infrared cluster. The comparisons with previous observations of Bok globules unassociated with bright rims and other objects are discussed. Most noteworthy is that the ratios of the bolometric luminosity to the circumstellar mass are significantly higher for these BRCs than for Bok globules.
General theory of lie groupoids and lie algebroids

Part I. The General Theory: 1. Lie groupoids: fundamental theory 2. Lie groupoids: algebraic constructions 3. Lie algebroids: fundamental theory 4. Lie algebroids: algebraic constructions Part II. The Transitive Theory: 5. Infinitesimal connection theory 6. Path connections and Lie theory 7. Cohomology and Schouten calculus 8. The cohomological obstruction Part III. The Poisson and Symplectic Theories: 9. Double vector bundles 10. Poisson structures and Lie algebras 11. Poisson and symplectic groupoids 12. Lie bialgebroids Appendix Bibliography Index.
Filtered gradient active fuzzy neural network noise control in an enclosure backed by a clamped plate

The performance of conventional linear algorithms in active noise control applications deteriorates facing nonlinearities in the system mainly because of loudspeakers. On the other hand, fuzzy logic and neural networks are good candidates to overcome this drawback. In this paper, the acoustic attenuation of noise in a rectangular enclosure with a flexible panel and five rigid walls is presented both theoretically and experimentally using filtered gradient fuzzy neural network (FGFNN) error back propagation algorithm in which the secondary path effect is implemented in derivation of updating rules. Considering this effect in updating rules leads to faster convergence and stability of the active noise control system. On the other hand, the primary path in the investigated system comprises an identified nonlinear model of loudspeaker inside the aforementioned box, parameters of which vary with the input current. The loudspeaker is identified using series‐parallel neural network model identification method. As a comparison, the performance of filtered‐x least mean squares and FGFNN algorithms are compared. It is observed that FGFNN controller exhibits far better results in the presence of loudspeakers with nonlinear behavior in primary path.Copyright © 2012 John Wiley & Sons, Ltd.
Temporal moments revisited: Why there is no better way for physically based model reduction in time

Many hydro(geo)logical problems are highly complex in space and time, coupled with scale issues, variability, and uncertainty. Especially time‐dependent models often consume enormous computational resources, but model reduction techniques can alleviate this problem. Temporal moments (TM) offer an approach to reduce the time demands of transient hydro(geo)logical simulations. TM reduce transient governing equations to steady state and directly simulate the temporal characteristics of the system, if the equations are linear and coefficients are time independent. This is achieved by an integral transform, projecting the dynamic system response onto monomials in time. In comparison to classical approaches of model reduction that involve orthogonal base functions, however, the monomials for TM are nonorthogonal, which might impair the quality and efficiency of model reduction. Thus, we raise the question of whether there are more suitable temporal base functions than the monomials that lead to TM. In this work, we will derive theoretically that there is only a limited class of temporal base functions that can reduce hydro(geo)logical models. By comparing those to TM we conclude that, in terms of gained efficiency versus maintained accuracy, TM are the best possible choice. While our theoretical results hold for all systems of linear partial or ordinary differential equations (PDEs, ODEs) with any order of space and time derivatives, we illustrate our study with an example of pumping tests in a confined aquifer. For that case, we demonstrate that two (four) TM are sufficient to represent more than 80% (90%) of the dynamic behavior, and that the information content strictly increases with increasing TM order.