Miracle-dz/UniFAR-FTUs huggingface dataset:
ADME-Tox profile of Cuminaldehyde (4-Isopropylbenzaldehyde) from Cuminum cyminum seeds for potential biomedical applications

Cuminum cyminum L (Family: Apiaceae) is a small multipurpose herb. Seeds of cumin are widely used as a spice for its distinctive aroma, and more commonly in various indigenous traditional systems of medicine. Access through web literature provides ample evidence for biomedical activities of Cuminum cyminum seeds (CCS). CCS has been used in traditional medicine to treat variety of diseases, including hypolipidemia, cancer, and diabetes. Biomedical properties of CCS is attributed to its phytochemical class of compounds viz., terpenes, phenols and flavonoids. Health effects of CCS have been experimentally validated through phytochemical screening deciphering the fact that it contains a large number of bioactive secondary metabolites (BASMs) viz., alkaloid, coumarin, anthraquinones, flavonoid, glycoside, protein, resin, saponin, tannin and steroid. Furthermore, pharmacological studies indicate that BASMs in CCS exert antimicrobial, insecticidal, anti-inflammatory, analgesic, antioxidant, anticancer, antidiabetic, anti-platelet-aggregation, hypotensive, bronchodilatory, immunological, contraceptive, anti-amyloidogenic, anti-osteoporotic, aldose reductase, α-glucosidase and tyrosinase inhibitory effects. Cuminaldehyde is one of the major bioactive compounds in CCS that holds significant pharmacological prominence. However, in-depth studies are lacking henceforth warranted to elucidate and fill the gaps, particularly on phytocompound isolation, pre-clinical, clinical characterization, and evaluation of structure–activity relationship. The present study prospects ADMETox perspectives of cuminaldehyde (4-Isopropylbenzaldehyde). Keywords: Cuminaldehyde; Isopropylbenzaldehyde; Cuminum cyminum; ADMETox; Natural Product (NP)
Comparison of the Use of Kinetic Model Plots and DD Solver Software to Evaluate the Drug Release from Griseofulvin Tablets

Awareness of the release kinetics of active drugs is important in formulating drugs that have the desired delivery and in predicting the behaviour of the formulated drug in vivo. The study aims to determine the mechanism of drug release from griseofulvin tablets formulated with different surfactants using mathematical models and to compare the use of graphs and DD solver software in fitting dissolution profiles to kinetic models. The batches P1 -P3 were composed of the surfactant - PEG 4000 in different concentrations. A control batch without surfactant and a commercial brand (Mycoxyl 500) were used for comparison. Granule and tablet quality tests indicated quality formulations. Dissolution profiles showed that the surfactant improved drug release of griseofulvin and batches (batches P1 -P3) formulated with PEG 4000 had the best release profiles comparable with the commercial brand. The Excel Add-in DD solver and kinetic plots were used to determine the kinetic model of best fit. The Higuchi model was the best fit for batches P1 -P3. The first order and Hixon -Crowell also fit batches P2 and P3. The Korsmeyer’s model showed that batches P1 -P3 exhibited anomalous diffusion. The tablets formulated with PEG were as good as the commercial brand and they had an anomalous diffusion of the drug from the tablet; meaning that drug diffused following Fickian law and also diffused through a swollen and porous matrix. Kinetic plots and the DD solver can be used for fitting dissolution profiles to kinetic models. Keywords: Griseofulvin, Kinetics, Models, Surfactants, Polyethylene glycol (PEG) 4000, DD solver, Dissolution profile, mathematical models
Optimization of Network Furniture Management System Based on Big Data

In order to make the traditional household equipment can be remotely controlled, wireless networking technology is introduced into the traditional furniture equipment to achieve the effect of access and remote control. In view of the problem that the traditional cloud storage system lacks flexibility, opacity, weak robustness and cannot effectively store, manage, and maintain big data in data storage, a big data oriented cloud storage system is designed and implemented to intelligently process the business requests of the furniture system through the logic control module. The user access module is used to provide users with various functions realized at the bottom, the storage module is used to provide transparent data access function for the furniture system, and the file read/write module is used to isolate the upper logic processing from the lower storage, so as to make the designed system more robust. In the process of software design, the program code of data cloud storage is given to realize big data cloud storage. The experimental results show that the new generation of network furniture cloud storage systems has high feasibility and practicability.
Hierarchical and On-Demand Attack Defence Framework for IoT Devices

Internet of Things (IoT) devices are lightweight such that they generally possess low battery power. Hence, the chances of battery exhaustion and flooding attacks are more. In order to perform attack response actions against various attacks, this paper proposes Hierarchical and On-Demand Attack Defence Framework (HOAD) for IoT security. In this framework, primary (PC) and secondary controller (SC) nodes are deployed in the network along with the IoT devices. The SC scan be moved on-demand by the PC. The response agent at PC will first establish a new route via the SCs by excluding the intruders and the suspected nodes. Then, it will resend the stored packets to their destination via the newly established route. The proposed HOAD framework is implemented in NS2 and compared with the MECshield framework. Simulation results show that the HOAD has reduced end-to-end delay, increased packet delivery ratio, and increased residual energy.
Evidence by reactivity with hybridoma antibodies for a probable myeloid origin of peripheral blood cells active in natural cytotoxicity and antibody-dependent cell-mediated cytotoxicity.

Lymphocytes with Fc receptors (FcR) for IgG active in natural cytotoxicity and antibody-dependent cellular cytotoxicity were separated into sheep erythrocyte rosetting (E+) and nonrosetting (E-) fractions, and examined for reactivity with the OK panel of hybridoma-produced monoclonal antibodies. Few cells in either the E+ FcR+ or the E- FcR+ fraction reacted with seven antibodies used to define T cells in various stages of differentiation (OK3, OKT4, OKT5, OKT6, OKT8, OKT9, OKT10). Neither fraction expressed an Ia-like antigen (detected by OKI1), but both were highly reactive with OKM1, an antibody that reacts with monocytes and granulocytes. Incubation of these cytotoxic effector cells with OKM1 plus complement abolished all cytotoxic reactivity, but incubation with a pan-T cell antibody (OKT3) plus complement had no significant effect. These cells were not monocyte precursors, because they could not be induced in vitro to develop macrophage characteristics. The data indicate that most cytotoxic effector cells in natural cytotoxicity and antibody-dependent cellular cytotoxicity are not in the T cell lineage, but have a myeloid origin. A B S T R A C T Lymphocytes with Fc receptors (FcR) for IgG active in natural cytotoxicity and antibody-dependent cellular cytotoxicity were separated into sheep erythrocyte rosetting (E+) and nonrosetting (E-) fractions, and examined for reactivity with the OK panel of hybridoma-produced monoclonal antibodies. Few cells in either the E+ FcR+ or the E- FcR+ fraction reacted with seven antibodies used to define T cells in various stages of differentiation (OKT3, OKT4, OKT5, OKT6, OKT8, OKT9, OKTIO). Neither fraction expressed an Ia-like antigen (detected by OKI 1), but both were highly reactive with OKM 1, an antibody that reacts with monocytes and granulocytes. Incubation of these cytotoxic effector cells with OKM 1 plus complement abolished all cytotoxic reactivity, but incubation with a pan-T cell antibody (OKT3) plus complement had no significant effect. These cells were not monocyte precursors, because they could not be induced in vitro to develop macrophage characteristics. The data indicate that most cytotoxic effector cells in natural cytotoxicity and antibody-dependent cellular cytotoxicity are not in the T cell lineage, but have a myeloid origin. immunoglobulin, pected. Lymphocytes stained with monoclonal antibodies while still bound to the immobilized complexes, or after they had detached spontaneously after overnight incubation on the complexes. Their reactivities with the anti- bodies were identical in both cases.
Hotel Online Reviews: Applied to Five-Star Hotels in the Town of Ain Sokhna in Egypt

The hotel industry in Egypt is an essential ingredient of the hospitality and tourism infrastructure. The ultimate purpose of this exploratory study is to better understand the areas that hotel management can eventually alter and develop, in order to obtain better results. For this purpose, an analysis of hotel guest satisfaction ratings based on attributes such as food, beach, room, location, and cleanliness was conducted across four five-star hotels in the town of Ain Sokhna in Egypt. This has been undertaken to better acknowledge the positive and negative sentiments of hotel guests. In accordance with this, the attributes that differentiate one hotel from another were identified to establish recommendations to hotel management for potentially enhancing their operations and guest satisfactions. Data from Booking.com was used to compare customer ratings on the afore-mentioned hotels. Statistical data analysis techniques were employed to underpin the key attributes that hotels should focus on and improve to ensure guest satisfaction.
Interspecific and intraspecific cross-compatibility of Durio kutejensis and hybrid Durio zibethinus x kutejensis

Abstract. Rudarmono, Ardiarini NR, Waluyo B, Ashari S. 2022. Interspecific and Intraspecific cross-compatibility of Durio kutejensis and hybrid Durio zibethinus x kutejensis. Biodiversitas 23: 1837-1843. Lai (Durio kutejensis) and Mandong (Durio zibethinus x kutejensis) fruits that have advantages and high consumer preference values. Fruit productivity and development of Lai and Mandong plant varieties are still not optimal. The aim of this study was to analyze the level of incompatibility of interspecific and intraspecific crosses between Lai (D. kutejensis) and Mandong (D. zibethinus x kutejensis hybrid) plants. Artificial crosses were made utilizing flower samples from Mahakam, Kutai, and Batuah types of Lai plants, as well as Mandong varieties of Mandong, employing a scheme of 20 crossings that included a combination of these varieties (12 treatments), as well as each variety from the same flower and tree (8 treatments). The intensity level and incompatibility classification were determined according to Wang's (1963) method, which was based on the number of fruits formed from artificial crosses, and the pollen incompatibility intensity level (IIL) was determined according to the ratio of flowers that produced fruit from the cross to the total number of flowers crossed. The results showed that overall crosses of the same flower (selfing) from three varieties of Lai and one variety of Mandong were incompatible. Lai Mahakam x Lai Batuah crosses yielded 14.28 % harvested fruit, Lai Mahakam x Lai Mahakam crosses yielded 18.75 % harvested fruit, Lai Kutai x Lai Kutai crossings yielded 14.81 % harvested fruit, while a cross of Durian Mandong x Lai Batuah yielded 16.67 % harvested fruit. It shows partially compatible. The complete compatibility value showed the number of harvested fruit ranged from 23.44 to 46.77%, with the most significant being obtained from a Lai Mahakam x Durian Mandong cross. The Mahakam, Kutai, Batuah, and Mandong varieties are compatible with all pollen sources.
Study of the effect of grape seed extract on the harmful effects of Monosodium Glutamate on chicken embryo Development

Monosodium Glutamate (MSG) is used in the food industry as a flavor enhancer added to thousands of food.Several studies have proven the damage caused by MSG on laboratory animals. Therefore, this study aims to study the effectiveness of grape seed extract(GSE) in mitigating MSG damage on chicken embryos, as part of the solutions provided in the event of the long term use of MSG and its accumulation in the body Human. In this study, we use 300 eggs were divided into six groups which are the control, MSG Group, GSE group, MSG+GSE , GSE than MSG and MSG than GSE. We are studying the effect of experimental materials in the fetal development during the following ages (7, 10, 12, 14, 16) day. The results showed that the treatment of embryos with MSG dose (0.1 ml) caused of the affect growth retardation, congenital malformations and Significant decrease in the weight and height of the fetuses and after the treatment of the fetus GSE was noted to reduce the damage. Grape seed extract has a curative effect in reducing the damages of mono-glutamate sodium on the development of chicken embryos. In a study conducted by ,2016) to investigate the effect of (MSG) on embryonic development in zebrafish, the acute toxicity of MSG was performed for 4 days and zebrafish eggs were injected with ten different concentrations of MSG. The results of the study indicated that at low concentrations Of MSG such as 10,30, 50 mg no mutations in embryonic development were observed, and with increased MSG various abnormalities occurred in zebrafish embryo and at high concentrations such as 100, 150, 200, 250, 300, 400, 500 mg, and These abnormalities were delayed growth, shrinkage of the placenta, edema of the sacral sacrum, absence of pigmentation in the fetus's body, The tail.
Risk Factors Associated with Tuberculosis Among Men; A Study of South Africa

One of the public health problems all over the world is tuberculosis. An important factor for human well-being is good health. Worldwide, there are more cases of men with tuberculosis than women. Therefore, identifying risk factors associated with tuberculosis among men is essential. This study uses a survey logistic regression model to identify risk factors associated with tuberculosis in South Africa using the 2016 South African Demographic Health Survey data. Based on the fact that tuberculosis status is a binary variable, logistic regression and survey logistics were used for analysis. The findings using the survey logistic model are presented. The results suggest that a survey logistic model that accounts for complex sampling design is better than logistic regression. The findings from the study show that the risk factors associated with tuberculosis are: chronic disease, current age, region, race, number of times away from home, marital status, weight, smoking status, the interaction effect of chronic disease and age, and the interaction effect of smoking status and number of household members. These factors can be used to implement strategies for reducing the risk of having tuberculosis.
A Study of Problems faced by Parents’ during Online Learning and their Managing Strategies

The need for virtual and online learning has been increased with the rapid growth of modern technology and knowledge, but the speed and volume of learning fluctuate. The study in hand is an intention to investigate the problems faced by parents’ during online learning and their managing strategies at university level. In addition it explored the role of parents towards the education of their children. The self-developed instrument, Parents’ Online Survey [POS], was used. The findings of the study showed that a statistically significant difference between male and female parents about the problems faced by parents during online education of their kids and as well as managing strategies of those problems. It revealed that male parents (fathers) were more conscious about the problems of their kids as they were the sole responsible to explore the solutions of those problems as compared with females (mothers). Parents use different management techniques to improve the virtual learning environment of the students like creating an ideal learning environment to their children, providing information technology and removing the learning barriers their kids face during virtual and online learning. They also managed the noise distortion, financial barriers encountered the non-academic attitude of the parents. It was suggested that there should be proper facilitation may be provided by the government to parents while starting the virtual and online sessions for students.
An overview of Betel vine (Piper Betle L.): Nutritional, pharmacological and economical promising natural reservoir

With its magnificent green heart-shaped leaf, the betel vine (Piper betle L.) is also known as Paan in India. It is a member of the Piperaceae family. It is cultivated in the coastal regions of Odisha (Balasore, Jagatsinghpur, Puri, Khordha, and Ganjam). Paan is consumed by over 1 million people throughout the state, but they are unaware of its high nutritional quality. It is considered superior to pharmaceuticals and is one of the best remedies in nature. It has anti-microbial, anti-apoptotic, anti-cancer, antioxidant, and anti-inflammatory attributes. Furthermore, the leaves retain eugenol-rich essential oil (EO) (1-3%), which is the hotspot for medication, stimulants, antiseptics, tonics, and other ayurvedic compositions. This oil can also be used as an industrial raw material to make medications, fragrances, tonics, mouth fresheners, food additives, and other products. It contains anticarcinogens, which show potential for the development of medicines against cancer treatment. Betel plant farming is an agricultural activity that provides a source of income for remote farmers. Sometimes economic crises occurred due to the development of diseases such as foot rot, leaf spot, powdery mildew, and collar rot. Most farmers got seasonal revenue, whereas betel vine cultivation provided year-round income from a tiny plot of land.
Effects of Minocycline on Cognitive Impairment, Hippocampal Inflammatory Response, and Hippocampal Alzheimer's Related Proteins in Aged Rats after Propofol Anesthesia

The aim of this study was to evaluate the effect of minocycline preadministration on cognitive dysfunction, hippocampal inflammatory response, and hippocampal senile dementia-related proteins induced by propofol anesthesia in aged rats. Sixty male SD rats, aged 20 months and weighing 340-410 g, were randomly divided into three groups: normal saline (NC) group, propofol group (prop), and minocycline (M) group. Prop group rats were injected intraperitoneally with 100 mg/kg propofol. The rats in group M were injected intraperitoneally with 50 mg/kg minocycline 30 minutes before injection of 100 mg/kg propofol, and the rest were the same as prop group. The rats in NC group were received intraperitoneal injection of the same amount of normal saline. The results indicated that compared with group C, the expressions of GSK-3β, acetyl-NF-κB (Lys310), Tau, and Amlyoid-beta were upregulated, the levels of TNF-α, IL-1β, and IL-6 were increased, the escape incubation period was prolonged, and the exploration time was shortened in prop group, while the expression of GSK-3β, acetyl-NF-κB (Lys310), Tau, and Amlyoid-beta in minocycline group was downregulated, the levels of TNF-α, IL-1β, and IL-6 were decreased, the escape incubation period was shortened, and the exploration time was shortened. In conclusion, preadministration of minocycline can improve cognitive impairment induced by propofol anesthesia in aged rats, and its mechanism of action may be related to minocycline inhibiting hippocampal inflammatory reaction and downregulating the expression of GSK-3β, acetyl-NF-κB (Lys310), Tau, and Amlyoid-beta proteins in hippocampus.
A comparison Between the Effect of Metformin and Progesterone on the Endometrium in cases of peri menopausal bleeding

Background: Unopposed oestrogen is have an effective role in the progress of endometrial benign, premalignant, and malignant lesions, according to various epidemiologic and experimental investigations. Aim of the work: To compare the special effects of metformin and progesterone on disorganised proliferative endometrium and simple endometrial hyperplasia and determine whether metformin is clinically effective in this circumstance. Patients and methods: This was a two blinded randomized controlled trial, was carried out on 100 patients at The Department of Obstetrics & gynecology at Al-Hussein University Hospital and El-Mahalla General Hospital, divided into 2 groups: (group1); 50 cases treated with metformin (Glucophage) five hndred milligram in the 1st week to one thousand milligram in the 4th week, (group2); 50 cases was managed medroxyprogesterone acetate (provera) 4mg once aday for three months. Results: The two group had similar result at dfenitive point such as uterine bleeding after treatment (p= 0.47), endometrial thickness after medication (P= 0.706). Also, there was no such big difference between the two studied groups as regards patient’s satisfaction and hysterectomy. The duration of treatment didn’t differ between the two groups. There was high statistically increase in incidence of painful breast, weakness and metallic taste in group 1 compared to group 2 while there was high statistically increase in incidence of nausea, vomiting and diarrhea in the 2nd group. Conclusion: Metformin could have the exact effect as progesterone in resolving of simple endometrial hyper plasia . Endometrial proliferative lesions should be detected with good management to avoid its complications.
How many more species are out there? Current taxonomy substantially underestimates the diversity of bent-toed geckos (Gekkonidae, Cyrtodactylus) in Laos and Vietnam

﻿Abstract Cyrtodactylus is the most diverse genus of the family Gekkonidae and the world’s third largest vertebrate genus. The number of species has increased more than fourfold over the last two decades. Indochina, especially Vietnam and Laos, has witnessed a surge in new species discoveries over the last three decades. The species number reported from Laos and Vietnam has remarkably increased from five in 1997 to 71 species in 2021. However, within the genus, several taxonomic issues have not yet been fully resolved. Based on recently collected samples from Laos and Vietnam, we conducted a comprehensive molecular review of Cyrtodactylus occurring in Laos and Vietnam. Our molecular analysis with support from morphological comparisons showed that C.thuongae is a junior synonym of C.dati and C.rufford is a junior synonym of C.lomyenensis. In total, 68 described species distributed in Laos and Vietnam are undisputed with strong support from both molecular and morphological evidence. On the other hand, the molecular analyses revealed that there are at least seven undescribed species in Vietnam and Laos, one in the C.angularis group, one in the C.chauquangensis, and five in the C.irregularis group. This number will likely increase significantly, as previous work suggested that the C.angularis and C.irregularis groups harbor three and six unnamed lineages, respectively. Based on survey gaps identified in our study, it is clear that additional new species will be discovered in poorly studied regions of central Vietnam and northern and southern Laos. As many species in the genus are facing high extinction risks, several undescribed populations might already be severely threatened by human activities in both countries. Therefore, urgent taxonomic research is needed before conservation assessments of newly discovered taxa can be undertaken to protect them from anthropogenic threats.