Miracle-dz/UniFAR-FTUs huggingface dataset:
Hh gene participates in the left-right asymmetry development of amphioxus by controlling Cer expression

: Correct patterning of left-right asymmetry is an important process during the embryonic development of bilaterians. It is known that Hh signaling plays a role in LR asymmetry development of mouse, chicken and sea urchin embryos by regulating Nodal expression. In this study, we reported a novel regulating way of Hh gene in the LR asymmetry development of amphioxus embryos. Our results revealed that Hh -/- embryos abolished Cerburs ( Cer ) transcription and led to bilaterally symmetric expression of Nodal , Lefty and Pitx . As a consequence, Hh -/- mutants duplicated its left-side structures and lost right-side characters displaying an abnormal bilaterally symmetric body plan. Those morphological LR defects and disturbed gene expressions in Hh -/- embryos could be precisely rescued by Hh mRNA injection. Our results indicate that Hh gene takes part in amphioxus LR patterning by controlling Cer gene expression. Curiously, however, upregulation of Hh signal failed to alter Cer expression pattern and LR morphology in amphioxus embryos, showing that Hh might not provide asymmetric cue for Cer expression. Besides, the observation also found that Hh gene is required for mouth opening in amphioxus, hinting a homologous relationship between amphioxus mouth and vertebrate mouth. in amphioxus LR asymmetry establishment. In this study, we display that Hh mutation of amphioxus results in morphologically symmetrical embryos in which the left-side organs are duplicated and presented on both sides, whereas the right-side structures are all lost. Moreover, we also examine the expression patterns of Cer , Nodal , Lefty and Pitx in Hh mutant embryos, and find that Cer expression After being photographed as whole mounts, the selected embryos were embedded in 1% agarose (1 g agarose in100 ml 0.5 M PBS), then dehydrated in ethanol series (30%, 50%, 60%, 70%, 80%, 95%, and 100%, 10 min each). Finally, the embryos were embedded in paraffin, sectioned at 5 µm, mounted in Poly lysine treated slide and stained with eosin according regular histological method.
Properties of Multicomponent Alloys Obtained by Additive Laser Technologies лазерными технологиями

A review of the research of foreign studies on the characterization of high-entropy alloys (HEA) is given in this article. It has been shown that HEA based on a body-centered lattice (BCL) of a solid solution are more heat-resistant than a highly entropic alloy based on a face-centered lattice (FCL) of a solid solution. The results of the obtained quasi-high-entropy alloys (QHEA) with new properties instead of expensive high-entropy alloys by introducing several serial powder materials based on iron, nickel, cobalt and tantalum nanocarbide additives to increase the wear resistance of coatings obtained by laser welding are presented. The introduction of 6% tantalum nanocarbide into the QHEA charge increases the wear resistance by 2.8 times compared to surfacing without carbide and increases the wear resistance by 7.2 times compared with the characteristic of the base material made of 40X steel. The technology of laser cladding QHEA can be used to restore various parts of machines, including those operating at elevated loads and temperatures. The characteristics of coatings obtained in the process of laser cladding are given. The range of variation of the operating parameters of the laser radiation is indicated: power of the displacement velocity, beam diameter. beam 8 mm / s. In this case, a uniform deposited bead and a minimum fusion zone of the sample base material of 5–15 μm were formed. Figure 1 (a and b) show microsections of deposited paths with a tantalum nanocarbide content of 6%, dimensions 0.85 × 2.3 mm, hardness 10200–10500 MPa, and 0.88 × 3.38 mm, hardness 10400–10900 MPa, obtained by defocused beam and beam scanning with a frequency of 215 Hz. The
Driver Drowsiness Detection for Accident Prevention Using EEG Signal

: Now a day Drowsiness is a major issue in case of traffic accident. Sometimes people will mentally sleep with eyes open for a few seconds that causes very big accidents in driving. So in this proposed paper I am analyzing the mental activities of brain using EEG signals based on Brain-Computer Interface (BCI) technology. This paper describes about an accident prevention method for vehicle based on brain computer interface (BCI). The pattern of interaction of neurons is changed according to human thoughts which produce electrical waves. A mentally sleeping person with open eyes has a changed attention level from the normal condition. This proposed method uses a brain wave sensor which detects the brain signals and converts it into packets and transmitted it through Bluetooth to the level analyzer unit (LAU) to check the attention level. Now the LAU analyses the attention level and gives the drowsy driving alert and keep the vehicle to be in self-controlled function until awaken state. This can save a lot of lives in road transportation.
REVEALING THE EFFECTIVENESS IN COMBINE USE OF VITAMIN B1, B6 AND B12 FOR TREATMENT OF DIABETIC PERIPHERAL NEUROPATHY

Objective: The purpose of our study was to find out the treatment effectiveness of the diabetic peripheral neuropathy with combine use of vitamin B1, B6 and B12. Study Design: Case control study on series of descriptive cases. Place and Duration: This study was carried out in the time period of 12 months starting from August, 2017 to September 2018 in Medical intensive care unit of Bahawal Victoria Hospital, Bahawalpur. Methodology: In this study the total numbers of patients selected were 310, who were having Endocrinology problem, Metabolism infection, diabetes mellitus and diabetic peripheral neuropathy. Unintentional sampling technique was used for selection of the samples. On the first visit, patients were described with Neurobion Tab (vitamin B1 & B6 100mg, B12 200cmg) for twice/day for the duration of one month and then they were called for followed checkup. According to the findings of our study the effectiveness was calculated with an enhancement in at least 2 pain points from the standard evaluated by the numerical pain rating scale. Results: Mean age of the patients was 46.70±8.60. Ratio of males and females out of total 310 patients was as 177 (57.0%) and 133 (42.90%) respectively. Periodic duration of diabetes as 0-10, 11-20, 21-30 and >30 years was found as 84 (27.09%), 138 (44.52%), 76 (24.52%) and 12 (3.87%) in all patients. Effectiveness rate of vitamin B1, B6 and B12 combination was 86.94% (270), during the treatment of diabetic peripheral neuropathy. Conclusion: According to the findings of our study treatment through combined vitamin B1, B6 and B12 were found effective in diabetic peripheral neuropathy.
Meta-Analysis Of Ecological Studies Attenuating Solar Radiation Illustrates The Importance Of Blue Light Over Ultraviolet Radiation In Driving Photodegradation Of Litter In Terrestrial Ecosystems

Qing-Wei Wang (  wangqingwei@iae.ac.cn ) Institute of Applied Ecology https://orcid.org/0000-0002-5169-9881 Marta Pieristè University of Helsinki Titta K. Kotilainen Natural Resources Institute Finland Estelle Forey Normandie Université Matthieu Chauvat Normandie Université Hiroko Kurokawa Forestry and Forest Products Research Institute T Matthew Robson University of Helsinki Alan G Jones Forest Systems
Dispersion-Corrected Stabilization Diagrams for Model Order Assessment in Structural Identification

This study aims at overcoming some of the inconsistencies of stabilization diagrams, by applying a novel dispersion analysis framework that relies on the effective modal decomposition of the vibration output’s zero-lag covariance matrix, under the assumption of broadband random excitation. A new metric is introduced, which expresses a certain part of the total stochastic vibration energy, and is attributed to each vibration mode. It is then shown how this metric can be integrated into a stabilization diagram, in order to enrich the displayed information and facilitate the model order selection process. In this respect, a vibration mode is identiﬁed as structural when it appears stabilized in both its frequency and its dispersion metric. The method’s performance is assessed through structural identiﬁcation problems from both simulated and experimental vibration data, for which subspace and prediction-error based methods are utilized.
Toll-Like Receptors 2 and 4 and their Association with the Pro/Anti Inflammatory Effects in Patients from Helminthiasis-Endemic Countries

There is a growing interest in the role of Toll-Like Receptors (TLRs) and the innate immunity in the pathogenesis of various diseases. The role of TLRs may go beyond the recognition of microbial molecules to boosting immunity, modulating inflammation, or regulating autoimmune diseases. This work aimed to study the association between helminth infection and the expression of Toll-Like Receptors (TLR2 & TLR4) in infected individuals and possible association with asthma prevalence/severity in such individuals. Forty-two helminth-infected patients and 20 matched controls of uninfected persons were included. The CD14+ monocytes were analysed for TLR2 and TLR4 by flow-cytometry and TLR2 mRNA was measured by RT-PCR semi-quantitatively. The results showed an increased expression of TLR2 in the helminth-infected patients vs. uninfected persons. Mean Fluorescence Intensity (MFI) was 56.9 ± 13 vs. 31.2 ± 11, p < 0.05. The MFI in the patients with severe vs. mild intensity of infection was 73.03 ± 6 vs. 51.08 ± 7, p > 0.05). TLR2 mRNA was increased in helminth-infected vs. uninfected participants by RT-PCR ( p <0.05). Asthma was found in 10/42 of the helminth-infected vs. 0/20 of the uninfected individuals (chi square 5.678, p < 0.05). No difference was found in TLR2-level in asthma vs. non-asthma patients (56.58±15 vs. 56.99±2.9, p >0.05), however there was a higher TLR2-expression with severe vs. less severe asthma ( p >0.05). TLR4-MFI didn’t show any significant difference in the studied groups. These results may underlie the role of TLR2 in the pathogenesis of both helminth infection and asthma and may introduce a novel approach to therapeutic developments.
Design, implementation and interpretation of in vitro batch culture experiments to assess enteric methane mitigation in ruminants—a review

In vitro fermentation techniques (IVFT) have been widely used to evaluate the nutritive value of feeds for ruminants and in the last decade to assess the effect of different nutritional strategies on methane (CH4) production. However, many technical factors may influence the results obtained. The present review has been prepared by the ‘Global Network’ FACCEJPI international research consortium to provide a critical evaluation of the main factors that need to be considered when designing, conducting and interpreting IVFT experiments that investigate nutritional strategies to mitigate CH4 emission from ruminants. Given the increasing and wide-scale use of IVFT, there is a need to critically review reports in the literature and establish what criteria are essential to the establishment and implementation of in vitro techniques. Key aspects considered include: i) donor animal species and number of animal used, ii) diet fed to donor animals, iii) collection and processing of rumen fluid as inoculum, iv) choice of substrate and incubation buffer, v) incubation procedures and CH4 measurements, vi) headspace gas composition and vii) comparability of in vitro and in vivo measurements. Based on an evaluation of experimental evidence, a set of technical recommendations are presented to harmonize IVFT for feed evaluation, assessment of rumen function and CH4 production. © 2016 Elsevier B.V. All rights reserved. Abbreviations: DM, dry matter; DMI, dry matter intake; IVFT, in vitro fermentation technique; NDF, neutral detergent fibre; OM, organic matter; VFA, olatile fatty acids. ∗ Corresponding author. E-mail address: david.yanez@eez.csic. es (D.R. Yáñez-Ruiz). http://dx.doi. org/10.1016/j.anifeedsci. 2016.03. 016 377-8401/© 2016 Elsevier B.V. All rights reserved. 2 D.R. Yáñez-Ruiz et al. / Animal Feed Science and Technology 216 (2016) 1–18
Appendix A : Model description Generalized Context Model

The GCM (Nosofsky, 1986) assumes that categorization decisions are based on similarity comparisons with individually stored category exemplars. Originally, the model was developed to account for categorization decisions, but it can be modified to account for typicality judgments (Nosofsky, 1988, 1991; Voorspoels, Vanpaemel, & Storms, 2008). Typicality of an exemplar i for a category A is calculated by summing the similarity of the exemplar to all other exemplars in the category:
Intelligent Management Systems for Energy Efficiency in Buildings : A Survey

Article Accepted version It is advisable to refer to the publisher's version if you intend to cite from the work. In recent years, reduction of energy consumption in buildings has increasingly gained interest among researchers mainly due to practical reasons, such as economic advantages and long-term environmental sustainability. Many solutions have been proposed in the literature to address this important issue from complementary perspectives, which are often hard to capture in a comprehensive manner. This survey article aims at providing a structured and unifying treatment of the existing literature on intelligent energy management systems in buildings, with a distinct focus on available architectures and methodology supporting a vision transcending the well-established smart home vision, in favor of the novel Ambient Intelligence paradigm. Our exposition will cover the main architectural components of such systems, beginning with the basic sensory infrastructure, moving on to the data processing engine where energy saving strategies may be enacted, to the user interaction interface subsystem, and finally to the actuation infrastructure necessary to transfer the planned modifications to the environment. For each component we will analyze di↵erent solutions, and we will provide qualitative comparisons, also highlighting the impact that a single design choice can have on the rest of the system.
Virtual Composition of EMF Models 1

Model composition is a very important modeling task as it allows to combine various perspectives of a system (represented by various models) into a single specialized view (a composed model). Several approaches have been proposed to tackle this problem, but they present some important limitations concerning efﬁciency, interoperability, and/or synchronization issues (mainly due to the element cloning mechanism used to create the composed model). In this paper we propose a new model composition method based on the virtualization of the composition mechanism. In our approach, the composed model is in fact created as a virtual model that redirects all its model access and manipulation requests directly to the set of base models from which it was generated. This is done transparently for the designer. Our mechanism improves the composition process with relation to the limitations mentioned above. The solution has been implemented and validated in a prototype tool on top of EMF.
An improved method for the harmonic contributions assessment of utility and customer in distribution systems: part A analytical study

A new method is proposed to find suitable definitions of electrical power components in non-sinusoidal conditions, which based on the analysis of three-phase instantaneous power flows of both fundamental and all harmonics of signals in three-phase non-sinusoidal system. This paper also introduces an attempt to get the physical essence of the proposed three-phase power components for any non-sinusoidal unbalanced three-phase system. Therefore, we can use the formulas of these definitions with modern digital measurement technology in order to reach to revenue meter which enables us to identify the responsible for the harmonic distortion between customers and distribution utilities. The aim of this paper is presenting an analytical study that will rely on it in the next paper part B, in order to assess the contributions of harmonic distortion for utility and the customer at the Point of Common Coupling (PCC).
FAIR TRADE IN A TOURIST PRODUCT FAIR TRADE W PRODUKCIE TURYSTYCZNYM

Summary: The main purpose of this theoretical and empirical article is to present the concept of Fair Trade and refer it to a tourist product, as well as to characterize the tourism market operating within the Fair Trade certification system. The subject of the analysis is the Fair Trade concept, its goals and principles, and its certification system in the context of a tourist product. The author of the article attempts to answer the question whether the concept of Fair Trade realized in the tourism sector can be helpful in achieving the goals of sustainable tourism, and what is the potential of Fair Trade Tourism in becoming the dominant idea/ concept and mainstream in the development of sustainable tourism. The article contains an analysis of selected aspects of Fair Trade Tourism based on annual reports of Fair Trade Tourism South Africa.
Improving Image Quality based on Feature Extraction and Gaussian Model

: By expanding the use of digital images in various areas of everyday life, such as medicine, identification, satellite imagery, and even personal cameras and machine vision, it is felt more effective in applying quality improvements to the images used. The low-quality images in the machine's vision can expose the efficacy of later processing, such as feature extraction, classification, and pattern recognition. In this thesis, a new method for improving the quality of images based on the extraction of Godin’s combined feature and model has been proposed. Based on the fact that each homogeneous region in the image has a Gaussian distribution histogram, this distribution can be divided into smaller histograms. For the histogram division efficacy, the image is transmitted from the RGB space to the HSV space and the histogram division is applied to the severity region, and the histogram is applied to each sub Histogram based on the statistical characteristics, and the image. Improved results are returned to the RGB color space. Several qualitative and quantitative criteria have been used to evaluate the proposed method. Qualitative comparison results show improved image quality compared to histogram equivalence methods and linear contrast traction. Quantitative evaluation criteria, such as entropy and spatial frequency, as well as signal to noise ratio, peak signal and peak signal to noise ratio, are generally proposed for superiority of the method.
Glucose and Electrolyte Absorption in Sepsis: Modulation Byangiotensin-(1-7)

Objectives: Studies have demonstrated the involvement of the renin- angiotensin system in electrolyte homeostasis. Endotoxemia causes dose-dependent changes in jejunal glucose, water and potassium absorption. The aim of the present study was to evaluate the effect of angiotensin-(1-7) [Ang-(1- 7)] on glucose and electrolytes jejunal absorption and its modulation on sepsis induced by lipopolysaccharide (LPS). Method: Wistar rats (n=6-10) received either saline (control), Ang-(1-7) at a dose of 2.5 nmol/kg intravenously (iv) or Ang-(1-7) + antagonist of its Mas receptor (A 779). In another set of experiments (n = 7 per group), Ang-(1-7) was administrated 30 min prior to sepsis induction by LPS (3 mg/kg IV). Six hours after sepsis induction, a Tyrode solution containing twice the usual concentrations of glucose, sodium, and potassium (pH 8.0) was infused through the jejunal loop for 40 minutes to investigate the intestinal absorption of sodium and potassium. Results: Ang-(1-7) increased glucose (51.6±3.2), and decreased sodium (32.03±1.96) and potassium (0.25±0.05) jejunal absorption when compared with the saline group (41.79±1.84, 53.01±0.94, 0.56±0.04respectively; p<0.05). The antagonist A-779 prevented this effect (30.54±3.34, 41.14±4.0, 0.65±0.12, respectively; p<0.05). LPS did not significantly affect glucose and electrolyte jejunal absorption. However, a decreased in sodium absorption was found with the combined injections of LPS+ Ang-(1-7) (21.48±6.70mM), in comparison to the control and LPS groups (55.31±4.90 and 46.86±6.86 mM, respectively; p<0.05). Conclusions: These data indicate that Ang-(1-7) modulates and LPS- induced sepsis does not impair glucose and electrolyte jejunal absorption. However, Ang-(1-7) maintains its effect on sodium absorption even in sepsis. Abbreviations A-779: Antagonist of Ang-(1-7); ACE: Angiotensin-Converting Enzyme; ACE2: Angiotensin-Converting Enzyme 2; Ang II: Angiotensin II; Ang-(1-7): Angiotensin-(1-7); ARDS: Adult Respiratory Distress Syndrome; BBM: Brush Border Membrane; IV: Intravenously; LPS: Lipopolysaccharide; Mas: Selective Receptor Of Angiotensin-(1-7); RAS: Renin-Angiotensin System; SGLT1: Sodium-Glucose Transport Proteins
RTCP CRAHN: A Renovated Transport Control Protocol for Cognitive Radio Ad Hoc Networks

: Cognitive Radio networks take into consideration about the users to transmit in the licensed spectrum bands, as long as the capability of the licensed User’s band is not degraded. Meanwhile, variation in vacant spectrum with time and frequent spectrum sensing undertaken by the cognitive radio users has a noticeable effect on the upper layer protocol capabilities, such as at the transport layer. During the allotment of unlicensed users there occurs a scheduling problem which increases the delay. This paper investigates the scheduling problem, and proposes RTCP CRAHN, a TCP-friendly protocol. A scheduling algorithm is being proposed to decrease the delay and increase the throughput. An analysis of the expected throughput in TCP CRAHN is provided, and simulation results reveal significant improvements by using our approach.
Health Monitoring and Fall Detection System for Elderly

Health and safety issues are very important for human beings in addition to health disease which are the number one cause of death in Malaysia as stated by Official Portal of the Ministry of Health Malaysia. Besides, the falls problem for the elderly is a big issue compared to young people, the problem of falls is a small incident but a no for seniors who have other subsequent relationships for chronic diseases such as osteoporosis which is high risk for fractures and difficult to recover from the falling incidents. This document proposes a combination of two systems which are health monitoring system and fall detection system based on the kinematic method that aims to aid elderly to constantly monitor their health condition and seek for assistance when they fell. It has two main part which are health monitoring system using pulse oximeter MAX30102 sensor and fall detection system using the IMU accelerometer and gyroscope of MPU-9250 sensor. In health monitoring system, there are three parameters measured which are heart rate (BPM), oxygen level (SPO2) and body temperature. The health information will be stored in BLYNK cloud for analysis process and will be displayed on the high contrast OLED screen display. While in fall detection system part, the MPU-9250 sensor analyses the acceleration and angular velocity of the user’s hand then alerting people nearby or emergency contact if the falling condition is detected. All continuous count of acceleration magnitude (AM) data will be taken and is calculated to be compared with the threshold set to indicate the falling condition. This study uses the Database and Online Analysis (BLYNK) technology as the data storage cloud, Wireless Interface Communication (IFTTT) application and buzzer as the emergency alert, and NodeMCU ESP32 as microcontroller.