Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Nrf2, STAT3, and Src as Molecular Targets for Cancer Chemoprevention

Cancer is a complex and multistage disease that affects various intracellular pathways, leading to rapid cell proliferation, angiogenesis, cell motility, and migration, supported by antiapoptotic mechanisms. Chemoprevention is a new strategy to counteract cancer; to either prevent its incidence or suppress its progression. In this strategy, chemopreventive agents target molecules involved in multiple pathways of cancer initiation and progression. Nrf2, STAT3, and Src are promising molecular candidates that could be targeted for chemoprevention. Nrf2 is involved in the expression of antioxidant and phase II metabolizing enzymes, which have direct antiproliferative action as well as indirect activities of reducing oxidative stress and eliminating carcinogens. Similarly, its cross-talk with NF-κB has great anti-inflammatory potential, which can be utilized in inflammation-induced/associated cancers. STAT3, on the other hand, is involved in multiple pathways of cancer initiation and progression. Activation, phosphorylation, dimerization, and nuclear translocation are associated with tumor cell proliferation and angiogenesis. Src, being the first oncogene to be discovered, is important due to its convergence with many upstream stimuli, its cross-talk with other potential molecular targets, such as STAT3, and its ability to modify the cell cytoskeleton, making it important in cancer invasion and metastasis. Therefore, the development of natural/synthetic molecules and/or design of a regimen that can reduce oxidative stress and inflammation in the tumor microenvironment and stop multiple cellular targets in cancer to stop its initiation or retard its progression can form newer chemopreventive agents.
Psychological Factors That Suppress Help-Seeking among Middle-Aged and Older Adults Living Alone

Help-seeking among destitute adults has not been adequately investigated. Therefore, this study clarifies the mechanisms that suppress help-seeking in middle-aged and older adults living alone. Data were collected from 1274 individuals (aged 50–79 years) who were living alone, using a survey that measured future time perspective, barriers to help-seeking, help-seeking intentions, and current and childhood economic statuses. Men living alone experienced lower help-seeking intention than women, were more likely to try to solve problems by themselves, and experienced greater distrust in others. No sex differences were observed in “future anxiety” and “resignation to the future. ” Poor economic status was associated with high “resignation to the future,” “future anxiety,” and “distrust of others” for both sexes. “Resignation to the future” was particularly higher among men with a poorer current economic status, which suppressed help-seeking. Abandoning hope for the future, which is characteristic of middle-aged and older men living alone, may inhibit help-seeking behavior.
Exploring the Value of Additional Primary Tumour Excision Combined with Systemic Therapy Administered in Different Sequences for Patients with de Novo Metastatic Breast Cancer

Introduction Uncertainty still remains regarding the survival improvement derived from immediate surgery or subsequent surgery in addition to systemic therapy for patients with de novo metastatic breast cancer. The current study aimed to examine the effect of combined treatment administered in different sequences on the survival of these patients. Materials and Methods We conducted a retrospective cohort study of patients with de novo stage IV breast cancer in the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2019. Patients were categorized into 3 groups: (1) systemic therapy without primary surgery, (2) systemic therapy after primary surgery, and (3) systemic therapy before primary surgery. Cumulative incidence curves with Gray's test were used to compare breast cancer-specific death (BCSD) between groups. Kaplan–Meier curves with the log-rank test were applied to compare overall survival (OS) between groups. A competing risk model and a proportional hazards model were generated to adjust for important prognostic factors. Propensity score matching (PSM) was performed in the primary survival analysis. Stratified analysis was also performed. Results Patients who underwent systemic therapy after primary surgery and who underwent systemic therapy before primary surgery both showed a significantly reduced risk of BCSD compared to patients who received systemic therapy without primary surgery [subdistribution hazard ratio (SHR): 0.74; 95% confidence interval (CI): 0.69–0.79; and P < 0.001, and SHR: 0.62; 95% CI: 0.56–0.67; and P < 0.001, respectively]. A statistically significant disparity was also noted in OS. In the setting of single-organ metastasis, including the bone, lung, and liver, patients receiving the combination therapy showed an improved prognosis compared with patients receiving systemic therapy without primary surgery. Conclusions Additional primary tumour excision, whether before or after systemic therapy, may provide survival benefits for patients presenting with de novo metastatic breast cancer, especially for patients with single-organ disease involving the bone, lung, and liver but not the brain. Further investigations mainly focused on these carefully selected candidates are required to improve personalized treatment for metastatic breast cancer.
Single-Atom Nanozymes: Fabrication, Characterization, Surface Modification and Applications of ROS Scavenging and Antibacterial

Nanozymes are nanomaterials with intrinsic natural enzyme-like catalytic properties. They have received extensive attention and have the potential to be an alternative to natural enzymes. Increasing the atom utilization rate of active centers in nanozymes has gradually become a concern of scientists. As the limit of designing nanozymes at the atomic level, single-atom nanozymes (SAzymes) have become the research frontier of the biomedical field recently because of their high atom utilization, well-defined active centers, and good natural enzyme mimicry. In this review, we first introduce the preparation of SAzymes through pyrolysis and defect engineering with regulated activity, then the characterization and surface modification methods of SAzymes are introduced. The possible influences of surface modification on the activity of SAzymes are discussed. Furthermore, we summarize the applications of SAzymes in the biomedical fields, especially in those of reactive oxygen species (ROS) scavenging and antibacterial. Finally, the challenges and opportunities of SAzymes are summarized and prospected.
Happiness and its Predictors among Undergraduate Students in Malaysia: A Systematic Review

Happiness of university students gradually decreases throughout their studies and does not return to pre-university levels, which prompts the investigation of mental health and wellbeing in university students. The primary objectives of this systematic review includes to explore the predictors of happiness among undergraduate students in Malaysian universities, to outline the strategies and recommendations to foster happiness at the same time to explore future directions of happiness research in Malaysia. Using PRISMA guidelines, a systematic search of major databases including PubMed, MEDLINE, CINAHL, SCOPUS, and Google Scholar published in the English language between the year January 2013 to January 2022. A total of 11 articles were retrieved and their results were synthesized. The review found predictors such as religious commitment, Islamic-based gratitude strategy, creativity, sedentary behaviour, physical activity, trait emotional intelligence, extraversion personality, creativity, non-attachment, psychological well-being attributes, and youth engagement in meaningful activities to have positive relationship with happiness. Importantly, mediation effects were also examined in six studies indicating that consideration for effect modifiers should be performed following each predictors of happiness. In short, evidence showed there are specific traits, behaviours, strategies, and other domains of life that consistently predicts level of happiness. However, this review could not provide firm conclusions due to several reasons. Firstly, most of the studies were cross sectional studies with pre-determined predictors. Also, the factions of participants from selected Malaysian universities and the variation of predictors discussed prompts for further exploration in increased inclusivity and volume of participants as well as investigation with different methodologies.
VIBRATION ANALYSIS OF A TRIMORPH PLATE FOR OPTIMISED DAMAGE MITIGATION

The dynamic response of a viscously damped rectangular trimorph plate subjected to a sinusoidally distributed load was investigated for simplysupported boundary conditions. The governing equation for the nonlinear deflection of the plate, which is first introduced in this paper, was derived based on the classical plate theory (CPT) and the classical laminate theory (CLT). The governing equation was solved using the Navier method and direct numerical integration. Optimised time-domain response plots for a trimorph plate made up of aluminium (Al), polyvinylidene fluoride (PVDF) and lead zirconate titanate (PZT) layers revealed that only three out of the six possible layer configurations are necessary for determining the best layer-stacking. In determining the best layer-stacking for the optimised dynamic response, three factors were considered namely: the stiffness, natural frequency and damping constant. Both of the Al/PVDF/PZT or Al/PZT/PVDF configurations were found to produce the best response qualities i.e. high elastic stiffness, high natural frequency and low viscous damping. Frequency-domain plots were generated to compare the nonlinear and linear responses and it was discovered that the effect of the nonlinearity predictably reduces the natural frequency of the trimorph plate. This study can be applied to the analysis of optimised damage mitigation of intelligent car bodies and safety critical structures which are subject to potentially destructive loading conditions.
Variation of morphological characteristics, total phenolic, and total flavonoid in Adenostemma lavenia, A. madurense, and A. platyphyllum

Abstract. Nurlela, Nurfalah R, Ananda F, Ridwan T, Ilmiawati A, Nurcholis W, Takemori H, Batubara I. 2022. Variation of morphological characteristics, total phenolic, and total flavonoid in Adenostemma lavenia, A. madurense, and A. platyphyllum. Biodiversitas 23: 3999-4005. Adenostemma has long been used as a herbal medication. Despite some studies regarding the morphology and potency of Adenostemma carried out, the variation of morphological traits, total phenolic content (TPC), and total flavonoid content (TFC) on different species of Adenostemma has been poorly investigated. This study was designed to observe the morphological characteristics, TPC, and TFC of Adenostemma lavenia, A. madurense, and A. platyphyllum. Morphological characteristics were observed using qualitative and quantitative parameters. The colorimetric method determined TPC and TFC in plant leaf ethanol extracts. The plants were morphologically diverse, which significant variation among the three species in plant height, length and width of leaf, and internodes distance. Morphological traits such as leaf length and width, plant height, and internodes distance significantly correlate with phenolic and flavonoid content in Adenostemma. These may be used as important selection criteria in Adenostemma for obtaining high phenolic and flavonoid content. The study revealed that different species of these plants with varying morphological traits substantially impact the content of their chemical compounds. The highest TPC and TFC were found in A. lavenia, suggesting that it is potentially an alternative source of bioactive compounds as herbal medicine.
Simulation of abdominal belt effects on IAP and spinal compressive force with musculoskeletal human model

Repeated High-G shocks and whole-body vibration (WBV) can increase the risk of fatigue and injuries in the lumbar region of the spine for crew and passengers on High-speed craft (HSC). Existing reviews have suggested the beneficial effects of abdominal belts regarding lumbar torso stabilization and spinal unloading. The paper provides a novel 3-D seated human model with a virtual belt to simulate the belt effects for occupants on HSC. The model is built with AnyBody, a commercial software for musculoskeletal simulation based on the inverse dynamics method. The belt behaves like an additional force exerted in the lumbar region, and the force magnitude has been optimized to avoid discomfort during long journeys. The belt effects have been studied with different levels of wave shock, anthropometries, and belt design parameters such as belt width and position. Wave shocks exerted on seat surface are considered to include both vertical and off-vertical (horizontal) acceleration and expressed with a half-sine pulse. The belt effects are evaluated with intra-abdominal pressure (IAP), transversus muscle activities, and spinal compressive force. The results have shown a combined increase of IAP (137% maximum) and a decrease of spinal compressive force at the L4/L5 joint (15.5% maximum) once the belt is applied under various circumstances. Transverse abdominis activity is also reduced with belt application. The belt performs best when it covers the entire lumbar region. Reduction of belt width might lead to increased muscle activity for the muscle that
Color Point Defect Detection Method Based on Color Salient Features

Display color point defect detection is an important link in the display quality inspection process. To improve the detection accuracy of color point defects, a color point defect detection method based on color salient features is proposed. Color point defects that conform to the perception of the human vision are used as the key point for detection. First, the human visual perception constraint coefficient is used to correct the RGB three-channel image to obtain the color-channel-transformed image. Then, the local contrast method is used to extract the point features of the color channel, which achieves point defect enhancement, noise and background suppression. Finally, the mean and standard deviation of the defect feature maps of R, G, and B channels are calculated. The maximum mean and standard deviation are selected as thresholds using the maximum fusion criterion to perform binarization segmentation of the defect feature maps of R, G, and B channels. An OR operation was performed on the segmented images and the point defect segmentation results were combined. The experimental results show that the average detection accuracy and recall of the algorithm is higher than 94%, which is a significant improvement compared with mainstream detection methods and meets the needs of industrial production.
Simple shear extrusion as an efficient severe plastic deformation technique: a review

Simple shear extrusion was designed in 2009 as a novel severe plastic deformation technique to obtain ultrafine-grained materials. During the past years, extensive work has been done to introduce and clarify this technique's characteristics and investigate its application in different areas of materials science and engineering. Owing to the inherent phenomenon of strain reversal associated with this technique and different available processing routes, this method is proven to be useful in material processing. This article aims to summarise the ability of this process to produce ultrafine-grained materials and discuss the potential of this process for industrialisation.
Comparison of quality of working life of anesthesia assistants of COVID-19 and Non-COVID-19 intensive care units

Background: The Coronavirus Disease 2019 (COVID-19) pandemic has exposed Anesthesia Assistants, "an essential and active group involved in the treatment and care of these patients, to a lot of stress that may affect their quality of working life. The aim of this study is to determine and understand the quality of life among anaesthesia assistants, who are coping with COVID-19 and non-COVID-19 intensive care units". Method: This cross-sectional study enrolled 1,100 Anesthesia Assistants of COVID-19 and non-COVID-19 intensive care working at the time of the COVID-19 outbreak in treatment centers in different regions of Iraq. "This study used the convenience sampling strategy. Data were collected using an interview questionnaire from anaesthesia assistants. The stepwise multiple linear regression models were used to examine the relationships among self-reported worrying regarding COVID-19 and SF-36 quality of life, its components, and subscales. Partial R was used as an estimate of effect size". Result: The mean SF-36 score was 65.2 (SD=17.6). "The mean score of the mental component summary (MCS) (M=56.8, SD=22.3) was lower than the mean score of the physical component summary (PCS) (M=69.5, SD=16.5)". The mean score of COVID-19 anxiety was 17.8 (SD=10.5).
Synthesis, Characterization and Anticancer Efficacy Studies of Iridium (III) Polypyridyl Complexes against Colon Cancer HCT116 Cells

In this paper, two new iridium (III) complexes, [Ir(ppy)2(ipbp)](PF6) (Ir1) (ppy = 2-phenylpyridine, ipbp = 3-(1H-imidazo[4,5-f][1,10]phenanthrolin-2yl)-4H-chromen-4-one) and [Ir(bzq)2(ipbp)](PF6) (Ir2) (bzq = benzo[h]quinolone), were synthesized and characterized. The cytotoxicity of the complexes against human colon cancer HCT116 and normal LO2 cells was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The complexes Ir1 and Ir2 show high cytotoxic efficacy toward HCT116 cells with a low IC50 value of 1.75 ± 0.10 and 6.12 ± 0.2 µM. Interestingly, Ir1 only kills cancer cells, not normal LO2 cells (IC50 > 200 µM). The inhibition of cell proliferation and migration were investigated by multiple tumor spheroid (3D) and wound healing experiments. The cellular uptake was explored under a fluorescence microscope. The intracellular reactive oxygen species (ROS), change of mitochondrial membrane potential, glutathione (GSH) and adenine nucleoside triphosphate (ATP) were studied. Apoptosis and cell cycle arrest were performed by flow cytometry. The results show that the complexes induce early apoptosis and inhibit the cell proliferation at the G0/G1 phase. Additionally, the apoptotic mechanism was researched by Western blot analysis. The results obtained demonstrate that the complexes cause apoptosis in HCT116 cells through ROS-mediated mitochondrial dysfunction and the inhibition of PI3K/AKT signaling pathways.
Design of the new CHARA instrument SILMARIL: pushing for the sensitivity of a 3-beam combiner in the H- and K-bands

Optical interferometry is a powerful technique to achieve high angular resolution. However, its main issue is its lack of sensitivity, compared to other observation techniques. Efforts have been made in the previous decade to improve the sensitivity of optical interferometry, with instruments such as PIONIER and GRAVITY at VLTI, or MIRC-X and MYSTIC at CHARA. While those instruments pushed on sensitivity, their design focus was not the sensitivity but relative astrometric accuracy, imaging capability, or spectral resolution. Our goal is to build an instrument specifically designed to optimize for sensitivity. This meant focusing our design efforts on different parts of the instrument and investigating new technologies and techniques. First, we make use of the low noise C-RED One camera using e-APD technology and provided by First Light Imaging, already used in the improvement of sensitivity in recent new instruments. We forego the use of single-mode fibers but still favor an image plane design that offers more sensitivity than a pupil plane layout. We also use a minimum number of optical elements to maximize the throughput of the design, using a long focal length cylindrical mirror. We chose to limit our design to 3 beams, to have the capability to obtain closure phases, but not dilute the incoming flux in more beam combinations. We also use in our design an edge filter to have the capability to observe Hand K-band at the same time. We use a low spectral resolution, allowing for group delay fringe tracking but maximizing the SNR of the fringes for each spectral channel. All these elements will lead to a typical limiting magnitude between 10 and 11 in both H- and K-bands.
Correlation between BAP1 Localization, Driver Mutations, and Patient Survival in Uveal Melanoma

Simple Summary 100 uveal melanomas from the UK were analyzed for molecular biomarkers, including alterations of chromosomes 3 and 8, cellular localization of BAP1, and genes known to be mutated in uveal melanoma. Consistent with earlier studies, loss of nuclear BAP1 (nBAP1) predicted shorter overall survival. Tumors with BAP1 loss of function mutations frequently exhibited heterogeneous BAP1 staining, and tumors with ≥25% loss of nBAP1 were a more reliable prognosistic indicator than chromosome 3 loss (LOH3) or chromosome 8q gain. Regardless of mutation class, most BAP1 mutations led to loss of nBAP1 and aberrant expression of cBAP1. Abstract Uveal melanoma (UM) is an uncommon but highly aggressive ocular malignancy. Poor overall survival is associated with deleterious BAP1 alterations, which frequently occur with monosomy 3 (LOH3) and a characteristic gene expression profile. Tumor DNA from a cohort of 100 UM patients from Moorfields Biobank (UK) that had undergone enucleation were sequenced for known UM driver genes (BAP1, SF3B1, EIF1AX, GNAQ, and GNA11). Immunohistochemical staining of BAP1 and interphase FISH for chromosomes 3 and 8 was performed, and cellular localization of BAP1 was correlated with BAP1 mutations. Wildtype (WT) BAP1 staining was characterized by nBAP1 expression with <10% cytoplasmic BAP1 (cBAP1). Tumors exhibited heterogeneity with respect to BAP1 staining with different percentages of nBAP1 loss: ≥25% loss of nuclear BAP1 (nBAP1) was superior to chr8q and LOH3 as a prognostic indicator. Of the successfully sequenced UMs, 38% harbored oncogenic mutations in GNA11 and 48% harbored mutations in GNAQ at residues 209 or 183. Of the secondary drivers, 39% of mutations were in BAP1, 11% were in EIF1AX, and 20% were in the SF3B1 R625 hotspot. Most tumors with SF3B1 or EIF1AX mutations retained nuclear BAP1 (nBAP1). The majority of tumor samples with likely pathogenic BAP1 mutations, regardless of mutation class, displayed ≥25% loss of nBAP1. This included all tumors with truncating mutations and 80% of tumors with missense mutations. In addition, 60% of tumors with truncating mutations and 82% of tumors with missense mutations expressed >10% cBAP1.
The Primary Pretenders

We call a composite number q such that there exists a positive integer b with b^p == b (mod q) a prime pretender to base b. The least prime pretender to base b is the primary pretender q_b. It is shown that there are only 132 distinct primary pretenders, and that q_b is a periodic function of b whose period is the 122-digit number 19568584333460072587245340037736278982017213829337604336734362- 294738647777395483196097971852999259921329236506842360439300.