Miracle-dz/UniFAR-FTUs huggingface dataset:
Locoregional Treatment in De Novo Metastatic Breast Cancer: A Retrospective Cohort Study

Background: In an earlier analysis of this cohort study, local therapy based on surgical resection of the primary tumor might confer a survival benefit in women with de novo metastatic breast cancer (dnMBC). Here we report the survival outcomes of locoregional treatment (LRT), focusing on the association of surgical timings and surgical margins with survival in these patients. Methods: The retrospective study included patients with dnMBC in two Chinese tertiary hospitals, between March 1, 2007, and December 31, 2017. Overall survival (OS) was evaluated by means of a stratified log-rank test and summarized with the use of Kaplan–Meier methods. Results: A total of 153 patients were included, of whom 87 underwent LRT and 66 systemic therapy alone (STA). LRT showed a significant OS benefit over STA (HR, 0.47; 95% CI, 0.33 to 0.69; p<.0001). Median OS of LRT group and STA group were 42 months (95% CI, 35.0 to 48.9 months) and 21 months (95% CI, 16.1 to 25.9 months), respectively. The benefit was consistent across most subgroups. The OS of patients undergoing surgery was better than that of patients without surgery (HR, 0.48; 95% CI, 0.33 to 0.70; p=.0001), and there was difference in survival improvement at different surgical timings (surgery before chemotherapy, during chemotherapy and after chemotherapy) (HR, 0.79; 95% CI, 0.65 to 0.95; p=.013). The survival benefit of surgery after chemotherapy was the most, followed by surgery during chemotherapy (Median 56 months, 95% CI, 40.8 to 71.2 months). Moreover, compared with patients with positive margins, the OS of patients with negative margins was significantly improved (HR, 2.35; 95% CI, 1.65 to 3.35; p<.0001), with a median OS of 56 months (95% CI, 45.9 to 66.1 months). Conclusions: Our results suggest that LRT is associated with improved OS in women with dnMBC, and patients who had surgery after or during systemic chemotherapy with negative surgical margins, are expected to benefit more.
Large-eddy simulation: a glance at the past, a gaze at the present, a glimpse at the future

Large-Eddy Simulation (LES) was originally proposed for simulating atmospheric flows in the 1960s and has become one of the most promising and successful methodology for simulating turbulent flows with the improvement of computational power. It is now feasible to simulate complex engineering flows using LES. However, apart from the computing power, significant challenges still remain for LES to reach a level of maturity that brings this approach to the mainstream of engineering and industrial
Marketing to Generation X

For decades, advertisers have pitched their ads toward Baby Boomers, the great demographic bubble of affluent individuals born between 1946 and 1964. As Boomers became advertising and media executives themselves, this trend was reinforced. But this emphasis on Baby Boomers to the exclusion of all others marginalized a group whos purchasing dollar is becoming more powerful every year-- Generation X. Advertisers and marketers can no longer afford to ignore this group, nor to appeal to Xers with warmed-over Boomer campaigns. Sixty-five million adult "Xers" came of age in a world radically different from the one that Boomers inherited. The decline of the economy and upsurge of divorce have made Xers more sober and cynical, yet more flexible and less ideological, about the definition of "family. " Although jaded by the materialistic '80's, they are on the whole much more comfortable with interactivity and other sophisticated technology than Boomers. Although disillusioned by the Boomer swing from activism in the '60's to status in the '80's, they are more tolerant of diversity and experiment than their forebears. Karen Ritchie, a pioneer in marketing to Xers, has produced the first serious introduction to Generation X for the advertiser. Ritchie begins by showing the significant statistical and demographic differences between Xers and Boomers in income, education, occupation, and rates of marriage and divorce. Next, she shows how the unprecedented ethnic diversity of Generation X shapes the attitudes and expectations of the group as a whole. Ritchie then takes us on a guided tour of the cultural influences that have brought Xers into adulthood, from MTV and infotainment to E-mail. Finally, Ritchie examines the buying tastes and habits of Generation X, noting that they are above all savvy, cost-conscious, and skeptical of "hype". Advertisers should embrace Generation X-- indeed they must, if they hope to survive into the next century. But in so doing, Ritchie suggests, they must modify existing advertising strategies to move away from Boomer fantasies and from the intrusive stereotypes that dominate current attempts to reach Generation X. They need to develop more realistic strategies that recognize both that generation's economic clout and its impact on marketing today.
Are We Sure that Adjuvant Chemotherapy is the Best Approach for Resectable Pancreatic Cancer? Are We in the Era of Neoadjuvant Treatment? A Review of Current Literature

The outcome of pancreatic cancer is poor, with a 9% 5-year survival rate. Current treatment recommendations in the 10%–20% of patients who present with resectable disease support upfront resection followed by adjuvant therapy. Until now, only early complete surgical (R0) resection and adjuvant chemotherapy (AC) with either FOLFIRINOX (5-fluorouracil, leucovorin, irinotecan, and oxaliplatin) or nab-paclitaxel plus gemcitabine have been shown to prolong the survival. However, up to 30% of patients do not receive adjuvant therapy because of the development of early recurrence, postoperative complications, comorbidities, and reduced performance status. The aims of neoadjuvant chemotherapy (NAC) are to identify rapidly progressing patients to avoid futile surgery, eliminate micrometastases, increase the feasibility of R0 resection, and ensure the completion of multimodal treatment. Neoadjuvant treatments are effective, but there is no consensus on their use in resectable pancreatic cancer (RPC) because of its lack of a survival benefit over adjuvant therapy. In this review, we analyze the advantages and disadvantages of the two therapeutic approaches in RPC. We need studies that compare the two approaches and can identify the appropriate sequence of adjuvant therapy after neoadjuvant treatment and surgery.
Selected models for the description of the kinematics of changes of height differences between points in a geodesic network under the influence of mining

The article attempts to describe the progress of deformation of the surface of the Legnica-Glogow Copper Mining Area in the years 1967-2008. The state of deformation has been described with kinematical models of the displacement of points representing the area under research. It has been analysed whether there are possibilities of using a counter-propagation algorithm for estimating displacements of selected points for which an assumption has been made that during the research they were damaged or destroyed. The numerical procedures of the estimation of parameters of displacement models were carried out by means of traditional optimisation methods and neural networks.
Principles of General Management: The Art and Science of Getting Results Across Organizational Boundaries

An up-to-date and comprehensive guide to the responsibilities of the general manager and the capabilities and tactics for meeting them Stop! If you have been looking for the one resource for managing a business of any size, this is it. Based on the extensive business experience of five experts, this authoritative guide provides an in-depth look at what every leader must know about managing across departments, functions, divisions, or companies. Drawing on decades of combined experience, John Colley and colleagues detail the wide range of skills, tools, and conceptual understanding as well as the qualities of leadership that a successful general manager must acquire. In an era of specialization and specialists, the authors return due focus to the generalist. No other book so passionately and thoroughly examines the roles and responsibilities of the general manager and the full scope of this distinct, pressure-filled occupation. The authors explore the quantitative and qualitative aspects of the job and discuss how the skilled manager moves an organization from abstract goals to definitive action. For every profit center or plant manager, function head, division president, or CEO, this book is indispensable reading.
Imaging of Pancreatic Carcinoma on Multidetector Computed Tomography, A Tertiary Care Experience at Liaquat National Hospital, Karachi

Introduction: Pancreatic cancer is a lethal disease. The mortality rate for pancreatic tumor has changed over the last 20 years. Early diagnosis of pancreatic carcinoma is very important for therapeutic decisions and surgical planning. Contrast enhance CT facilitated the detection of primary tumor and staging. Objective: This study is to evaluate various presentations of pancreatic carcinomas on their initial MDCT (Multidetector Computed Tomography) and to evaluate its resectability and to compare CT features among resectable and non-resectable tumors. Methodology: All the patients underwent multi-phasic CT scan on a 16-slice MDCT. CT findings were analyzed included tumor location, size, enhancement pattern, nodal disease, duct dilatations, vascular involvement and evidence of metastatic disease. Results: Total 63 records of patients examined during 2017 and 2019 meeting the inclusion criteria were reviewed. The average age at time of MDCT examination was 62.51 ± 13.17 years. The disease was more common in males (n=36, 57.1%). Out of 63 pancreatic tumors, 14 (22.22%) tumors were identified as resectable tumors on MDCT examination. Tumor size (p<0.001), peripancreatic nodes (p=0.006), contrast enhancement (p=0.018), vessel involvement (p<0.001), ascites (p=0.006), hepatic metastases (p=0.001) and peripheral organ involvement (p<0.001) were significantly different among resectable and non-resectable tumors. Conclusion: MDCT is an excellent and most commonly used modality for diagnosis and staging of pancreatic carcinoma particularly with a high sensitivity for detection of vascular invasion and metastatic disease.
Finite Element Analysis in Geotechnical Engineering: Theory

This book aims to provide geotechnical and structural engineering practitioners, researchers and postgraduate students with an insight into the use of finite element methods in geotechnical contexts, in order that they might make good judgements as to the credibility of the numerical results they may obtain or review in the future. The contents of the chapters are geotechnical analysis, finite element theory for linear materials, geotechnical considerations, real soil behaviour, elastic constitutive models, elasto-plastic constitutive models, advanced constitutive models, finite element theory for non-linear materials, seepage and consolidation, three-dimensional finite element analysis, and fourier series aided finite element method. The book is primarily aimed at users of commercial finite element software both in industry and academia.
Design of Miniaturized Planar SIW Diplexers Using Dual-Mode Resonators

In this paper, two planar diplexers using dual-mode resonators are designed, which have achieved significant size miniaturization. The first diplexer is made of a simple single dual-mode resonator as a square cavity in the substrate integrated waveguide technology. The two degenerate modes with 90 ◦ rotation are perturbed by the placement of metallic via and CPW lines as input and output ports. A prototype model of this diplexer is designed and fabricated in the X-band. Its simulation results and measurement data agree very well. An isolation of 22 dB is achieved between two ports, which is quite suitable for receiving systems. For the improvement of isolation and bandwidth, the degree of structure is increased, whereby dual-mode resonators are used to connect the channel filters to the input port. Those types of channel filters are used which generate a transmission zero in the frequency band of the other channel. The isolation and bandwidth of the diplexer have been improved significantly, where its size is much smaller than the common diplexers.
Systematic Mapping of Value-based Software Engineering : A Systematic Review of Value-based Requirements Engineering

Context: In many organizations, practices and processes of software engineering are carried out in a value-neutral setting. These value-neutral settings within software development are responsible for project failures. Value-based software engineering (VBSE) manages these value neutral settings by integrating value-oriented perspectives into software engineering. The fundamental factors that differentiate VBSE from value-neutral software engineering are value dimensions that play a crucial role in companies' success by managing customer needs, demands, and expectations Objectives: The aims of this master thesis are to 1) systematically classify the contributions within VBSE and 2) investigate practical application and validation of solutions in industry to determine their practical usability and usefulness. Methods: In this study, systematic mapping, followed by systematic review were used as research methods. Results: The findings of systematic mapping show that a clear majority of value-based research has been conducted within requirements engineering, and verification and validation. Whereas, there were not many studies discussing value-based design. In terms of research types used, evaluation research and solution proposal were the most dominant contributions. While experience reports and philosophical research were less emphasized. In general, value-based contributions such as recommendations and processes were highly reported in VBSE studies. In addition, the finding of systematic review indicates that although many solutions were proposed for value-based requirements engineering but in the absence of qualitative and quantitative results from usability and usefulness perspectives make it hard for practitioners to adopt for industrial practices. Conclusion: The systematic classification of studies and resulting maps not only give an overview of existing work on VBSE but also identifies interesting research gaps which can be used by researchers to plan and carry out future work. The findings of systematic review can be used by industry practitioners to assess the level of applicability of the proposed value-based requirements engineering solutions with respect to their application/validation context and usability and usefulness.
What about Gastric Schwannoma? A systematic review

Background Gastric schwannomas (Gs) are rare mesenchymal neoplasms of the gastrointestinal tract. Diagnosis is commonly achieved by pathological examination of resected specimen. In most cases surgical resection of submucosal gastric lesions is performed with wide margins. New minimally invasive techniques are described in an increasing number of cases. Methods A Pubmed, Cochrane and Embase systematic review of the literature has been performed. Original papers, review articles, case reports published between 1988 and 2019 were considered eligible. Only papers written in English with full text available have been included. Articles reporting a follow up period, the type of treatment of the primary tumor and the appearance of local or distant recurrence were compared and analysed. Statistical analysis of data has been performed using GraphPad Prism 7 software. Results 328 articles were found and a total of 102 were included in the analysis. Fifty-three papers reported the follow-up information, ranging from 1-417 months across different studies. Among them, 31 patients underwent endoscopic removal of the gastric lesions, 140 patients local surgery, including wedge resection or partial gastrectomy and 148 patients underwent subtotal or total gastrectomy. The median follow-up was of 27-38-33 months respectively. No recurrence or distant metastasis were detected in endoscopic group. Among local surgery group, liver metastasis was reported in one case; in extended surgery group one patient died for multiple liver metastases. Conclusions In comparison with endoscopic group, local or more extended surgery involved a larger cohort of patients and reported satisfactory long-term results. Surgical approach in absence of a definite pre-operative diagnosis is considered the gold standard treatment for resectable Gs due to the excellent long-term outcome. Further studies are warranted to define the role of endoscopic treatment. Keywords : Schwannoma, neurinoma, gastric neurinoma, gastric schwannoma.
PERSONAL INFORMATION ARCHIVING: BEHAVIOURAL RESPONSES TO THE PERCEPTION OF RISK

The paper investigates the factors that influence perceptions of online risk and the consequential behavioural responses to those perceptions. Using Bates’ theory of information behaviour, we focus on online protection strategies and digital archiving as a specific instantiation and manifestation of information behaviour and analyze how factors, such as perceptions of online risk and self-reported internet skills, have consequences for information behaviours. The study uses semi-structured interview data (n=101) collected from East York, Toronto. We asked about individuals’ perception of risk online, self-reported internet skills, protective measures when going online, and digital archiving practices. Our findings identify a nuanced relationship between perceptions and behaviours. The results offer an alternate perspective on online information behaviour that departs from traditional classifications that rely on _demographics_. We offer a refinement to the definitions of information behaviour by Bates (2010) and Fisher and Julien (2009) to include factors that modify behaviours, and develop a user typology relating specifically to perceptions of risk online.
MPLS-Enabled Applications: Emerging Developments and New Technologies

With a foreword by Yakov Rekhter"Here at last is a single, all encompassing resource where the myriad applications sharpen into a comprehensible text that first explains the whys and whats of each application before going on to the technical detail of the hows. "Kireeti Kompella, CTO Junos, Juniper NetworksThe authoritative guide to MPLS, now in its Third edition, fully updated with brand new material! MPLS is now considered the networking technology for carrying all types of network traffic, including voice telephony, real-time video, and data traffic. In MPLS-Enabled Applications, Third Edition, the authors methodically show how MPLS holds the key to network convergence by allowing operators to offer more services over a single physical infrastructure. The Third Edition contains more than 170 illustrations, new chapters, and more coverage, guiding the reader from the basics of the technology, though all its major VPN applications.MPLS Enabled-Applications contains up-to-date coverage of:The current status and future potential of all major MPLS applications, including L2VPN, L3VPN, pseudowires and VPLS.A new chapter with up to date coverage of the MPLS transport profile, MPLS-TP.MPLS in access networks and Seamless MPLS, the new architecture for extending MPLS into the access, discussed in depth for both the unicast and the multicast case.Extensive coverage of multicast support in L3VPNs (mVPNs), explaining and comparing both the PIM/GRE and the next generation BGP/MPLS solutions, and including a new chapter on advanced topics in next generation multicast VPNs.A new chapter on advanced protection techniques, including detailed discussion of 50 ms end-to-end service restoration.Comprehensive coverage of the base technology, as well as the latest IETF drafts, including topics such as pseudowire redundancy, VPLS multihoming, IRB and P2MP pseudowires.MPLS-Enabled Applications will provide those involved in the design and deployment of MPLS systems, as well as those researching the area of MPLS networks, with a thoroughly modern view of how MPLS is transforming the networking world. "Essential new material for those trying to understand the next steps in MPLS. "Adrian Farrel, IETF Routing Area Director"MPLS-Enabled Applications takes a unique and creative approach in explaining MPLS concepts and how they are applied in practice to meet the needs of Enterprise and Service Provider networks. I consistently recommend this book to colleagues in the engineering, education and business community. "Dave Cooper, Chief IP Technologist, Global Crossing Ltd
Physiological tests for elite athletes

Quality assurance in exercise physiology laboratories pretest preparation estimating peak power and anaerobic capacity of athletes blood lactate thresholds anthropometric assessment protocols blood sampling and handling techniques measuring flexibility for performance and injury prevention determining maximal oxygen consumption (V\od\O2max) or maximal aerobic power testing protocols for team sport players introduction to assessing strength and power limitations to isometric testing in athletic assessment isokinetic dynamometry strength assessment protocols for the physiological assessment of: basketball players, cricket players, cross-country skiers and biathletes high-performance track, road and mountain cyclists golfers male and female field hockey netball players rowers rugby union players high-performance runners sailors male and female soccer players softball players swimmers high-performance tennis players high-performance triathletes elite water polo players.
COMPREHENSIVE PROGRAM NEEDED TO REDUCE YOUTH DWI

Several approaches have been used to reduce the alcohol-related crash rate among young drivers. Some policy and legislative approaches are discussed, together with some strategies based on education and persuasion. The two general types of legal and policy approaches are those designed to reduce young people's access to alcohol, and those designed to reduce driving by young people or restrict the circumstances in which they drive. In the 1980s, the drinking age in the USA was raised to 21, and many young lives were saved as a result. Research indicates that the following additional legislative and policy measures would be effective: (1) more vigorous enforcement of minimum age for buying alcohol; (2) decreased availability of alcohol to youth, especially through higher prices; (3) graduated and provisional licensing for young drivers; (4) raising the age of licensing; (5) lower blood alcohol content (BAC) levels for youth; and (6) licence revocation for drink-driving offences. It would be much better and cost-effective if people could be persuaded that impaired driving is not in the best interests of individuals or society. Research is now being done to understand better the motivations, values, and norms that can prevent or promote impaired driving behaviour. For the covering abstract, see IRRD 866577.