Miracle-dz/UniFAR-FTUs huggingface dataset:
Problems of HLAW Hybrid Welding of S1300QL Steel

This paper presents the results of tests on the fabrication of welded joints in S1300QL steel according to the requirements of ISO 15614-14 and ISO 12932. The butt-welded joint without bevel was made from 350 × 150 × 8 mm sheets. The welding process was carried out at the hybrid welding (laser–MAG) station. MAG means metal active gas. The test welded joints were subjected to non-destructive and destructive testing. Visual and radiographic examinations were carried out. The distribution of HV10 hardness was determined in the weld, the heat-affected zone, and the base material. The microstructure of these areas was also analysed for the presence of hard and brittle hardening products and non-metallic inclusions. Tensile strength and yield strength, as well as bending strength, were assessed in the mechanical property tests. The impact test was performed in accordance with ISO 9016.
Range, Doppler and astrometric observables computed from Time Transfer Functions: a survey

Determining range, Doppler and astrometric observables is of crucial interest for modelling and analyzing space observations. We recall how these observables can be computed when the travel time of a light ray is known as a function of the positions of the emitter and the receiver for a given instant of reception (or emission). For a long time, such a function--called a reception (or emission) time transfer function--has been almost exclusively calculated by integrating the null geodesic equations describing the light rays. However, other methods avoiding such an integration have been considerably developped in the last twelve years. We give a survey of the analytical results obtained with these new methods up to the third order in the gravitational constant $G$ for a mass monopole. We briefly discuss the case of quasi-conjunctions, where higher-order enhanced terms must be taken into account for correctly calculating the effects. We summarize the results obtained at the first order in $G$ when the multipole structure and the motion of an axisymmetric body is taken into account. We present some applications to on-going or future missions like Gaia and Juno. We give a short review of the recent works devoted to the numerical estimates of the time transfer functions and their derivatives.
Empirical approximation of Nash equilibria in finite Markov games with discounted payoffs

This paper deals with finite nonzero‐sum Markov games under a discounted optimality criterion and infinite horizon. The state process evolves according to a stochastic difference equation and depends on players' actions as well as a random disturbance whose distribution is unknown to the players. The actions, the states, and the values of the disturbance are observed by the players, then they use the empirical distribution of the disturbances to estimate the true distribution and make choices based on the available information. In this context, we propose an almost surely convergent procedure—possibly after passing to a subsequence—to approximate Nash equilibria of the Markov game with the true distribution of the random disturbance.
Inflammatory Bowel Disease Guidelines for Corneal Refractive Surgery Evaluation

Inflammatory bowel disease (IBD) is a chronic systemic inflammatory condition that can potentially adversely affect surgical outcomes in patients receiving elective ophthalmic procedures. In this case series, 21 eyes of 11 patients with ulcerative colitis or Crohn’s disease underwent laser in situ keratomileusis (LASIK), photorefractive keratectomy (PRK), or small incision lenticule extraction (SMILE). Their surgical outcomes were followed up for an average of 8.9 ± 4.6 months. All the patients in this study did well, with 100% of eyes corrected for distance vision achieving uncorrected distance visual acuity 20/20 by postoperative month three. Common symptoms noted during the postoperative period included dry eyes, irritation, foreign body sensation, and blurry vision, all of which improved in prevalence and severity over the follow-up period, and none of the patients experienced a flare-up of their disease. Despite the successful outcomes in these patients, the authors recognize the inherent risks of operating on patients with IBD. Currently, there are no consensus guidelines for clinicians to follow to ensure that they are adequately screening these patients for eligibility, so the authors are suggesting a relevant, focused review of systems, a brief IBD history-related questionnaire, and a preliminary surgical decision-making flowchart for use in surgical evaluation.
Effects of Natural Rheum tanguticum on the Cell Wall Integrity of Resistant Phytopathogenic Pectobacterium carotovorum subsp. Carotovorum

The abuse of agricultural antibiotics has led to the emergence of drug-resistant phytopathogens. Rifampicin and streptomycin and streptomycin resistance Pectobacterium carotovorum subsp. carotovorum (PccS1) was obtained from pathological plants in a previous experiment. Rheum tanguticum, derived from the Chinese plateau area, exhibits excellent antibacterial activity against PccS1, yet the action mode has not been fully understood. In present text, the cell wall integrity of the PccS1 was tested by the variation of the cellular proteins, SDS polyacrylamide gel electrophoresis (SDS-PAGE), scanning electron microscopy (SEM) and Fourier transform infrared spectrophotometer (FTIR) characteristics. Label-free quantitative proteomics was further used to identify the DEPs in the pathogen response to treatment with Rheum tanguticum Maxim. ex Balf. extract (abbreviated as RTMBE). Based on the bioinformatics analysis of these different expressed proteins (DEPs), RTMBE mainly inhibited some key protein expressions of beta-Lactam resistance, a two-component system and phosphotransferase system. Most of these membrane proteins were extraordinarily suppressed, which was also consistent with the morphological tests. In addition, from the downregulated flagellar motility related proteins, it was also speculated that RTMBE played an essential antibacterial role by affecting the swimming motility of the cells. The results indicated that Rheum tanguticum can be used to attenuate the virulence of the drug-resistant phytopathogenic bacteria.
The Proteasome Activator PA200/PSME4: An Emerging New Player in Health and Disease

Proteasomes comprise a family of proteasomal complexes essential for maintaining protein homeostasis. Accordingly, proteasomes represent promising therapeutic targets in multiple human diseases. Several proteasome inhibitors are approved for treating hematological cancers. However, their side effects impede their efficacy and broader therapeutic applications. Therefore, understanding the biology of the different proteasome complexes present in the cell is crucial for developing tailor-made inhibitors against specific proteasome complexes. Here, we will discuss the structure, biology, and function of the alternative Proteasome Activator 200 (PA200), also known as PSME4, and summarize the current evidence for its dysregulation in different human diseases. We hereby aim to stimulate research on this enigmatic proteasome regulator that has the potential to serve as a therapeutic target in cancer.
Curvature-Variation-Inspired Sampling for Point Cloud Classification and Segmentation

Point cloud is a discrete and unordered expression of 3D data. A lot of methods have been proposed to solve the problem in 3D object classification and scene recognition. To handle the huge amount of unordered point cloud, down-sampling before processing is needed. The shortage of existing sampling methods is the lack of geometry information consideration, which is essential for point cloud classification and segmentation tasks. Our method is mainly motivated by the observation that points with a high curvature variation can depict the outlines of objects. Thus, we propose a curvature variation based sampling method for point cloud classification and segmentation tasks. We aim to sample points with high curvature variations, which are considered to be more suitable for classification and segmentation tasks than the traditional sampling method. We combine the proposed sampling algorithm with the existing sampling method for multiple information fusion, and a higher accuracy and mean IoU can be achieved. The experimental results verify the advantage of considering curvature variation in classification and segmentation tasks.
“It’s Our Own Community Where We Can Educate Other People and Educate Each Other”: Youth Perspectives on Staffing a Textline

Abstract Peer education is a valued strategy for sexuality education and health promotion. Innovative approaches beyond traditional classroom settings offer critical opportunities to support adolescent sexual health. Yet, such models have been rarely used. It’s OK to Ask Someone (IOTAS) is the first to use customized software to enable youth to both ask and answer sexual health questions using cell phones. This article describes an evaluation aimed to understand high school peer educators’ experience staffing IOTAS and perception of how participation impacted their peer education training. Our findings suggest a value in direct peer education opportunities for participants through IOTAS in expanded education and skill development. The health promotion impact of sexuality education using cell phone interventions could be far-reaching for both peer education students and young people outside program participation.
Monte Carlo Simulations of Shear‐Thinning Flow in Geological Fractures

The hydraulic behavior of fractured rocks under shear‐thinning flow is a challenging topic of interest in several fields, related either to environmental remediation or to natural resources recovery. The compound effect of fluid rheology and medium heterogeneity strongly affects flow and transport in fractured geological formations. Here, a stochastic analysis is conducted via Monte Carlo simulations to investigate the flow of shear‐thinning fluids in fractures subjected to both natural and forced flow, considering different fracture dimensions, for a spatial correlation of the fracture that is an intrinsic parameter of the geological formation, independent of the fracture size. Considering the lubrication approximation, a generalized Reynolds equation for shear‐thinning fluids is solved using an ad hoc, finite volume‐based, numerical scheme. The influence of the rheology and aperture field heterogeneity on ensemble statistics of the velocity components and magnitude, as well as apparent fracture‐scale transmissivity, is quantified over 103 fracture realizations. The probability density functions (PDFs) and relative confidence intervals, obtained by averaging over the statistics, are analyzed to characterize the apparent transmissivity transition from Newtonian to shear‐thinning regime. The autocorrelation functions of velocity components are computed to understand the impact of rheology on spatial correlations the flow. Velocity components exhibit narrow PDFs with nearly exponential decay. More elevated pressure gradients emphasize the shear‐thinning behavior, inducing a more pronounced flow localization, under otherwise identical conditions. This translates at the scale of the fracture into a larger apparent transmissivity as compared to the same configuration with Newtonian rheology, by orders of magnitude.
Smart Lacelock: A Novel Shoelace Tensioning Device for Human Motion Sensing

Shoe-mounted wearable sensors may serve a variety of important purposes (activity recognition, energy expenditure estimation, and so on) by providing rich information about human locomotion. However, reliably attaching such sensors to shoes still remains a challenge. Furthermore, pressure-sensing elements in such shoe sensor systems often suffer from poor durability due to the large dynamic load. This work presents a novel shoe-mounted sensor named Smart Lacelock, which takes the form of a common shoelace tensioning device (shoelace lock). With its unique form factor, the Smart Lacelock can be securely attached to the top of a shoe with minimal effort, enabling its embedded inertia measurement unit (IMU) to provide reliable 3-D motion measurement of the foot. Furthermore, the Smart Lacelock incorporates a load cell to measure the force applied by the shoelace, providing valuable information related to ankle movement, foot/shoe shape change, and ground force. Design details of the device are presented, including the mechanical structure and electronic circuitry. We also conducted a ten-participant human study, in which signals were recorded during free ankle swing, body weight (BW) shifting, sit-to-stand (STS), and overground walking. The results demonstrated the Smart Lacelock’s capability of providing consistent and observable responses to single contributing factors (ankle movement and foot loading) as well as complex movements with clearly defined events of interest (STS and walking). Such unique capability suggests that the Smart Lacelock may serve as an important source of human movement information to support related applications such as activity recognition and gait event detection.
Evaluation of female masculinization in Pomacea canaliculata (Caenogastropoda, Ampullariidae) induced by tributyltin, heavy metals, and uranium in culture water

All female Pomacea canaliculata develop a small, male-like copulatory apparatus a few days after birth, which growths slowly until sexual maturity, and even further in older age. Previous studies have found trace elements like mercury (Hg), arsenic (As) and uranium (U) in tap water used for snail culture, and that these elements were accumulated in snail tissues. Here, we test whether the presence of these metals at maximum allowed concentrations (Environmental Protection Agency - EPA) in aquarium water could affect the development of the copulatory apparatus in mature females. Females of different ages were used as controls, grown in reconstituted metal-free water with or without the addition of Hg, As and U, as well as tributyltin (TBT), a compound used as masculinizing agent. Six and seven months old females cultured in tap water showed a longer penis and penile sheath, and a greater overall development of the copulatory apparatus, measured by an index (DI), as compared with same-age females cultured in reconstituted water. Moreover, when females were exposed to Hg, As or U at the maximum contaminant levels for human consumption allowed by EPA regulations, there was no further development of the copulatory apparatus, while there was a clearly positive effect in TBT-exposed females. This study confirms the masculinizing effect of organotin compounds on female copulatory apparatus and discusses the usefulness of the development of these organs as a bioindicator of environmental pollution.
Investigating parent attitudes from the perspective of learning experiences in a museum

ABSTRACT Museums are important locations providing cognitive resources to children in various subjects. Literature suggests that parent–child interaction in the museum differs across cultures. Two of the main reasons for this are the overall attitude towards the child and the autonomy provided. The data reveals that the most decisive factor was parents’ attitudes towards the autonomy of the child. Research primarily focuses on the structure of parent–child interaction in Turkey in the context of museums, and how often scaffolding strategies are used by parents. It also examines how using these strategies differ in terms of parental attitudes toward children and their caretakers as well as their own individual children. The person selecting the object to talk about (mother-father–child) during the interaction process was accepted as an indicator of autonomy support, and how the scaffolding strategies differed correspondingly was investigated. Parents mostly used strategies of mobilization/maintenance and detailed explanation.
Molecular Profiling of Tumor Tissue in Mexican Patients with Colorectal Cancer

Colorectal cancer is a heterogeneous disease with multiple genomic changes that influence the clinical management of patients; thus, the search for new molecular targets remains necessary. The aim of this study was to identify genetic variants in tumor tissues from Mexican patients with colorectal cancer, using massive parallel sequencing. A total of 4813 genes were analyzed in tumoral DNA from colorectal cancer patients, using the TruSight One Sequencing panel. From these, 192 variants with clinical associations were found distributed in 168 different genes, of which 46 variants had not been previous reported in the literature or databases, although genes harboring those variants had already been described in colorectal cancer. Enrichment analysis of the affected genes was performed using Reactome software; pathway over-representation showed significance for disease, signal transduction, and immune system subsets in all patients, while exclusive subsets such as DNA repair, autophagy, and RNA metabolism were also found. Those characteristics, whether individual or shared, could give tumors specific capabilities for survival, aggressiveness, or response to treatment. Our results can be useful for future investigations targeting specific characteristics of tumors in colorectal cancer patients. The identification of exclusive or common pathways in colorectal cancer patients could be important for better diagnosis and personalized cancer treatment.
As carreiras do magistério federal e a greve dos docentes de 2012: relações com um projeto educacional

Abordaremos neste artigo a análise e os resultados de uma pesquisa documental, que versa acerca das repercussões sobre a carreira e o trabalho docente arquitetado através da ação dos governos de conciliação de classes, que atuaram no sentido de reconverter as Universidades Públicas aos interesses de expansão do capital acerca da educação, principalmente a superior. O foco é a carreira docente como parte de um projeto de Universidade Pública, que a partir da imposição da Lei 12.772/2012 (BRASIL, 2012b), aprovada contra o movimento docente no contexto de grande mobilização da greve docente de 2012, culminou na desestruturação completa da carreira docente e numa reforma universitária fatiada com perspectiva privatista e mercadológica.
Establishing an In Vitro System to Assess How Specific Antibodies Drive the Evolution of Foot-and-Mouth Disease Virus

Viruses can evolve to respond to immune pressures conferred by specific antibodies generated after vaccination and/or infection. In this study, an in vitro system was developed to investigate the impact of serum-neutralising antibodies upon the evolution of a foot-and-mouth disease virus (FMDV) isolate. The presence of sub-neutralising dilutions of specific antisera delayed the onset of virus-induced cytopathic effect (CPE) by up to 44 h compared to the untreated control cultures. Continued virus passage with sub-neutralising dilutions of these sera resulted in a decrease in time to complete CPE, suggesting that FMDV in these cultures adapted to escape immune pressure. These phenotypic changes were associated with three separate consensus-level non-synonymous mutations that accrued in the viral RNA-encoding amino acids at positions VP266, VP280 and VP1155, corresponding to known epitope sites. High-throughput sequencing also identified further nucleotide substitutions within the regions encoding the leader (Lpro), VP4, VP2 and VP3 proteins. While association of the later mutations with the adaptation to immune pressure must be further verified, these results highlight the multiple routes by which FMDV populations can escape neutralising antibodies and support the application of a simple in vitro approach to assess the impact of the humoral immune system on the evolution of FMDV and potentially other viruses.
Comments on “removal of methylene blue dye from aqueous solution using citric acid modified apricot stone”

Abstract The work mentioned in the title of this comments-typed paper contains several calculations that disagree with some basic chemistry concepts. These misleading calculations mainly include (i) both kinetic and isotherm modeling through linear equations and (ii) calculating the thermodynamic parameters for the adsorption processes. Thus, we remind how to correct ways allowing to make these calculations. In our opinion, it is a source of confusion for the scientific community to continue using inappropriate methods as applied in the original paper.
Altered asymmetries of resting‐state MRI in the left thalamus of first‐episode schizophrenia

Abstract Background Schizophrenia (SCZ) is a complex psychiatric disorder associated with widespread alterations in the subcortical brain structure. Hemispheric asymmetries are a fundamental organizational principle of the human brain and relate to human psychological and behavioral characteristics. We aimed to explore the state of thalamic lateralization of SCZ. Methods We used voxel‐based morphometry (VBM) analysis, whole‐brain analysis of low‐frequency fluctuations (ALFF), fractional amplitude of low‐frequency fluctuations (fALFF), and resting‐state seed‐based functional connectivity (FC) analysis to investigate brain structural and functional deficits in SCZ. Also, we applied Pearson's correlation analysis to validate the correlation between Positive and Negative Symptom Scale (PANSS) scores and them. Results Compared with healthy controls, SCZ showed increased gray matter volume (GMV) of the left thalamus (t = 2.214, p = 0.029), which positively correlated with general psychosis (r = 0.423, p = 0.010). SCZ also showed increased ALFF in the putamen, the caudate nucleus, the thalamus, fALFF in the nucleus accumbens (NAc), and the caudate nucleus, and decreased fALFF in the precuneus. The left thalamus showed significantly weaker resting‐state FC with the amygdala and insula in SCZ. PANSS negative symptom scores were negatively correlated with the resting‐state FC between the thalamus and the insula (r = −0.414, p = 0.025). Conclusions Collectively, these results suggest the possibility of aberrant laterality in the left thalamus and its FC with other related brain regions involved in the limbic system.
The Classification of Blazar Candidates of Uncertain Types

In this work, the support vector machine (SVM) method is adopted to separate BL Lacertae objects (BL Lacs) and flat spectrum radio quasars (FSRQs) in the plots of the photon spectrum index against the photon flux, αph∼logF, those of the photon spectrum index against the variability index, αph∼logVI and those of the variability index against the photon flux, logVI∼logF. Then, we used the dividing lines to distinguish BL Lacs from FSRQs in the blazar candidates of uncertain types from the Fermi/LAT catalogue. Our main conclusions are: 1. We separate BL Lacs and FSRQs by αph=−0.123logF+1.170 in the αph∼logF plot, αph=−0.161logVI+2.594 in the αph∼logVI plot and logVI=0.792logF+9.203 in the logVI∼logF plot. 2. We obtain 932 BL Lac candidates and possible BL Lac candidates, and 585 FSRQ candidates and possible FSRQ candidates. 3. Discussion is given regarding comparisons with the literature.