Miracle-dz/UniFAR-FTUs huggingface dataset:
INNOVATE WITH GLOBAL INFLUENCE: Tales of High-Tech Intrapreneurs

In 2009, in the midst of a global economic crisis, a weary and discouraged innovation community gathered together at the Nokia Theater in New York City. After two days of passionate debate, a remarkable new framework for corporate innovation began to emerge. Multi-national corporations must seek and unite their global intrapreneurs. From one hemisphere to the next, these young intrapreneurs leverage a surprising corporate culture and deliver their own game-changing ideas: - In Shanghai, China, an idea from a second-year programmer triggers millions of dollars in product sales. - A software developer in Tel Aviv, Israel, travels the world to insert his creation into hundreds of new high-tech devices. - A field engineer in Cork, Ireland, delivers an electronic shredding solution to businesses paralyzed by the complex maze of governmental legislation. - A technologist in Bangalore, India, creates breakthrough security software to protect data centers from hundreds of cyber-threats. - A Russian intrapreneur delivers critical information capture software eighteen months ahead of schedule. - Beijing researchers create groundbreaking new search algorithms that protect the privacy concerns associated with personal data. Read their stories. Learn their secrets. Discover the competitive advantage of a globally united innovation network.
Numerical and analytical evaluation of stirrup-induced confinement on resistance of RC beams using lower bound limit analysis

In this paper, a modified three-dimensional element is introduced for limit analysis of RC structures, which considers more aspects of structural behaviour. Using the introduced element, the influence of stirrup confinement on the shear and moment resistance of RC beams is evaluated by lower bound limit analysis. To analyse and solve the relevant optimization problem, the semidefinite programming method, SDP, is employed. The modified Mohr–Coulomb yield criterion is utilized to constrain the concrete stress state. Beams with a constant amount of shear reinforcement per unit length, with different values of stirrup spacing, are studied. It means that they only differed in the effect of confinement induced by stirrup reinforcements. The performance of the proposed element is verified by comparing the results of numerical limit analyses with experimental results. This comparison revealed the efficiency and accuracy of the proposed model and the capability of the introduced element to take the effect of stirrup-induced confinements into account. After modelling and investigating the effect of stirrup confinement in load bearing of RC beams, a simplified equation for the design and practical purposes is proposed. Using this equation, the shear resistance of the beams could be modified for different stirrup space choices. The results obtained from this simplified equation are compared with numerical limit analysis and experimental results. The comparisons indicate the reasonable accuracy of the proposed equation.
Role of Cardiac Magnetic Resonance Imaging in the Evaluation of Athletes with Premature Ventricular Beats

Premature ventricular beats (PVBs) in athletes are not rare. The risk of PVBs depends on the presence of an underlying pathological myocardial substrate predisposing the subject to sudden cardiac death. The standard diagnostic work-up of athletes with PVBs includes an examination of family and personal history, resting electrocardiogram (ECG), 24 h ambulatory ECG (possibly with a 12-lead configuration and including a training session), maximal exercise testing and echocardiography. Despite its fundamental role in the diagnostic assessment of athletes with PVBs, echocardiography has very limited sensitivity in detecting the presence of non-ischemic left ventricular scars, which can be revealed only through more in-depth studies, particularly with the use of contrast-enhanced cardiac magnetic resonance (CMR) imaging. The morphology, complexity and exercise inducibility of PVBs can help estimate the probability of an underlying heart disease. Based on these features, CMR imaging may be indicated even when echocardiography is normal. This review focuses on interpreting PVBs, and on the indication and role of CMR imaging in the diagnostic evaluation of athletes, with a special focus on non-ischemic left ventricular scars that are an emerging substrate of cardiac arrest during sport.
Irisin Promotes Cardiac Homing of Intravenously Delivered MSCs and Protects against Ischemic Heart Injury

Few intravenously administered mesenchymal stromal cells (MSCs) engraft to the injured myocardium, thereby limiting their therapeutic efficacy for the treatment of ischemic heart injury. Here, it is found that irisin pretreatment increases the cardiac homing of adipose tissue‐derived MSCs (ADSCs) administered by single and multiple intravenous injections to mice with MI/R by more than fivefold, which subsequently increases their antiapoptotic, proangiogenic, and antifibrotic effects in rats and mice that underwent MI/R. RNA sequencing, Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway analysis, and loss‐of‐function studies identified CSF2RB as a cytokine receptor that facilitates the chemotaxis of irisin‐treated ADSCs in the presence of CSF2, a chemokine that is significantly upregulated in the ischemic heart. Cardiac‐specific CSF2 knockdown blocked the cardiac homing and cardioprotection abilities of intravenously injected irisin‐treated ADSCs in mice subjected to MI/R. Moreover, irisin pretreatment reduced the apoptosis of hydrogen peroxide‐induced ADSCs and increased the paracrine proangiogenic effect of ADSCs. ERK1/2‐SOD2, and ERK1/2‐ANGPTL4 are responsible for the antiapoptotic and paracrine angiogenic effects of irisin‐treated ADSCs, respectively. Integrin αV/β5 is identified as the irisin receptor in ADSCs. These results provide compelling evidence that irisin pretreatment can be an effective means to optimize intravenously delivered MSCs as therapy for ischemic heart injury.
Andricus partali n. sp. from Costa Rica (Hymenoptera: Cynipidae: Cynipini)

A new species of oak gallwasp, Andricus partali n. sp. (Hym., Cynipidae: Cynipini), is described from Costa Rica inducing galls on the leaves of Q. costaricensis Liebm. (Section Lobatae). We provide a description, diagnosis, and information about the distribution and biology of the new species.
Profile of Visual Thinking of Mathematics Teachers Candidates in Designing STEM-Based Learning

It can be said that STEM is the actualization of thematic learning. Prospective teachers in general and prospective mathematics teachers in particular need to learn to design STEM-based learning. This paper provides an overview of visual thinking of prospective mathematics teacher students in designing STEM-based learning. The research method used is an explorative descriptive research method with a qualitative approach. The subject of research is the 5 th semester student of the Mathematics Education Study Program of Universitas PGRI Madiun academic year 2019/2020. Data collection is done with in-depth task-based interviews. Triangulation time is used to obtain saturation and validity and data. Valid data is analyzed by coding, data reduction, data exposure, categorization, and abstraction so that conclusions are obtained. The results showed that in the visual thought of designing STEM-based learning mathematics teacher candidates use contextually visualizations on the objectives, activities, times, and tools to be used in learning.
Resilient Control Plane Design for Inter-Datacenter Cloud Network with Various Attacks

By decoupling the control plane (CP) from the data plane (DP), software-defined inter-datacenter cloud networking (SD-IDCN) paradigm can provide centralized network control and management (NC&M) for cloud platform provider. Although decoupled, the CP of an SD-IDCN usually shares the infrastructure with the DP physically, which is vulnerable to various security threats, such as software attack of disabling the controller node or even physical attack of cutting down the network link. In this paper, we consider the threats of SD-IDCN’s threatens of network nodes and links, which can be launched intentionally. Under the circumstances, we study the problem of resilient CP design assisted by game theory. Specifically, the problem is modeled as a non-cooperative game between two players, i.e., the designer and the attacker, whose strategies are different CP design schemes and different attack schemes, respectively. The designer’s utility function is positively correlated with the connectivity in the residual network after an attack, with which the attacker’s utility function is negatively correlated. Assuming that both players are rational to maximize their own utilities, we discuss whether the game is degenerate or not and accordingly solve the game to obtain the Nash Equilibrium (NE) (i.e., the solution of the game). Extensive simulations are performed in USNET backbone topology to evaluate the game theoretic CP design approach with different scenarios.
Flatness Prediction of Cold Rolled Strip Based on Deep Neural Network with Improved Activation Function

With the improvement of industrial requirements for the quality of cold rolled strips, flatness has become one of the most important indicators for measuring the quality of cold rolled strips. In this paper, the strip production data of a 1250 mm tandem cold mill in a steel plant is modeled by an improved deep neural network (the improved DNN) to improve the accuracy of strip shape prediction. Firstly, the type of activation function is analyzed, and the monotonicity of the activation function is deemed independent of the convexity of the loss function in the deep network. Regardless of whether the activation function is monotonic, the loss function is not strictly convex. Secondly, the non-convex optimization of the loss functionextended from the deep linear network to the deep nonlinear network, is discussed, and the critical point of the deep nonlinear network is identified as the global minimum point. Finally, an improved Swish activation function based on batch normalization is proposed, and its performance is evaluated on the MNIST dataset. The experimental results show that the loss of an improved Swish function is lower than that of other activation functions. The prediction accuracy of a deep neural network (DNN) with an improved Swish function is 0.38% more than that of a deep neural network (DNN) with a regular Swish function. For the DNN with the improved Swish function, the mean square error of the prediction for the flatness of cold rolled strip is reduced to 65% of the regular DNN. The accuracy of the improved DNN is up to and higher than the industrial requirements. The shape prediction of the improved DNN will assist and guide the industrial production process, reducing the scrap yield and industrial cost.
cT1N0M0 Esophageal Squamous Cell Carcinoma Invades the Muscularis Mucosa or Submucosa: Comparison of the Results of Endoscopic Submucosal Dissection and Esophagectomy

Simple Summary Esophagectomy has been the standard treatment for superficial esophageal squamous cell carcinoma (SESCC) that invades the muscularis mucosa or submucosa. This retrospective study aimed to assess the effects of endoscopic submucosal dissection (ESD) combined with selective adjuvant chemoradiotherapy on these SESCCs by comparing the results of esophagectomy. We found no significant differences in overall survival, disease-specific survival, and progression-free survival between the two groups. In the ESD group, the procedure time, overall complication rates, and length of hospital stay were significantly reduced, but the rate of metachronous tumor recurrence was significantly increased. Therefore, ESD combined with selective adjuvant chemoradiotherapy can be an alternative treatment to esophagectomy for SESCC invading the muscularis mucosa or submucosa. Abstract Background: Endoscopic submucosal dissection (ESD) combined with selective adjuvant chemoradiotherapy may be a new treatment option for cT1N0M0 esophageal squamous cell carcinoma (ESCC) invading muscularis mucosa or submucosa (pT1a-M3/pT1b). We aim to report the effectiveness of this treatment by comparing the results of esophagectomy. Methods: This retrospective single-center study included 72 patients with pT1a-M3/pT1b ESCC who received ESD combined with selective adjuvant chemoradiotherapy (n = 40) and esophagectomy (n = 32). The main outcome comparison was overall survival (OS). The secondary outcomes were treatment-related events, including operation time, complication rate, and length of hospital stay. Disease-specific survival (DSS) and progression-free survival (PFS) were also evaluated. Results: There were no significant differences in the rates of OS, DSS, and PFS between the two groups (median follow-up time: 49.2 months vs. 50.9 months); these were also the same in the subgroup analysis of pT1b ESCC patients. In the ESD group, the procedure time, overall complication rates, and length of hospital stay were significantly reduced. However, the metachronous recurrence rate was significantly higher. In a multivariate analysis, tumor depth and R0 resection were the independent factors associated with OS. Conclusions: ESD combined with selective adjuvant chemoradiotherapy can be an alternative treatment to esophagectomy for cT1N0M0 ESCC invading muscularis mucosa or submucosa.
The Role of Tumor Microenvironment in the Pathogenesis of Sézary Syndrome

Sézary syndrome is an aggressive leukemic variant of cutaneous T-cell lymphomas, characterized by erythroderma, lymphadenopathy, and peripheral blood involvement by CD4+ malignant T-cells. The pathogenesis of Sézary syndrome is not fully understood. However, the course of the disease is strongly influenced by the tumor microenvironment, which is altered by a combination of cytokines, chemokines, and growth factors. The crosstalk between malignant and reactive cells affects the immunologic response against tumor cells causing immune dysregulation. This review focuses on the interaction of malignant Sézary cells and the tumor microenvironment.
Combined α- and β-adrenergic receptor activation triggers thermogenesis by the futile creatine cycle

Noradrenaline is the primary physiological regulator of adipocyte thermogenesis in response to decreased environmental temperature1. However, the molecular factors and effector pathways that lie downstream of noradrenaline-stimulated thermogenesis are still not fully understood but are purportedly driven by cAMP downstream of β-adrenergic receptor (βAR) activation. Furthermore, while the transcriptional mechanisms regulating Ucp1 are well-characterized2, the transcriptional regulation of UCP1-independent thermogenesis is largely unknown. Here, we show that brown adipose tissue (BAT) is primed to respond to environmental cold by triggering coordinated α-adrenergic receptor (αAR) and βAR signaling to induce the expression of thermogenic genes of the futile creatine cycle3,4. Using fat-specific loss-of-function models, we reveal that EBFs, ERRs, and PGC1α are required for the cold-stimulated transcriptional induction of the futile creatine cycle in vivo. Through the application of chemogenetics, we demonstrate that combined fat-selective Gαs (activated by βARs) and Gαq (activated by αARs) signaling elevates whole-body energy expenditure to a greater extent than either signaling pathway alone in a manner that is dependent on the key effector protein of the futile creatine cycle, CKB3. Moreover, genetic and pharmacological studies reveal that CKB is necessary for nearly all of the α1AR-stimulated component of brown adipocyte-intrinsic respiration and is thus critical for the full activation of noradrenaline-stimulated thermogenesis. Thus, the futile creatine cycle is integrated into facultative and adaptive thermogenesis through coordinated α1AR and β3AR signaling.
The seductive allure effect extends from neuroscientific to psychoanalytic explanations among Turkish medical students: preliminary implications of biased scientific reasoning within the context of medical and psychiatric training

Abstract Research suggests that people tend to overweight arguments accompanied by neuroscientific terminology, which is dubbed as the seductive allure of neuroscience explanations (SANE) in the literature. Such an effect might be of particular significance when it comes to physicians and mental health professionals (MHP), given that it has the potential to cause significant bias in their understanding as well as their treatment approaches toward psychiatric symptoms. In this study, we aimed to test the SANE effect among Turkish medical students, and assess its uniqueness by comparing it with a discipline that still maintains an important role in contemporary psychiatric training in Turkey: psychoanalysis. 109 medical students with a basic level of knowledge of psychiatry and clinical neuroscience were asked to rate the credibility of explanations of differing quality (good vs. circular) for psychological phenomena, followed by three types of information: none, neuroscientific (SNI) or psychoanalytical (SPI). Our findings showed that SNI significantly increased the judged quality of explanations for both conditions with the effect being more prominent for circular explanations. On the other hand, SPI had no effect on good explanations but enhanced the judged quality of circular explanations in a level comparable to that of SNI. For the first time, the SANE effect was replicated among medical students and provided preliminary data in favor of a similar effect for psychoanalytically oriented information.
Characterization of hybrid frequency selective surface (FSS)

This paper presents the characterization of Frequency Selective Surface (FSS) on hybrid materials to minimize the signal loss in a wireless medium using various objects at 2.4 GHz. The FSS structure is designed in two basic configurations; rectangular FSS and trapezoid FSS. In each design have three types of structures, single FR4 substrate, dual FR4 substrates and dual hybrid substrates. The results show that rectangular FSS with dual hybrid substrates (Rogers RO3010 + Glass) without any gap has the highest inductive effect of (0.865i + 0.251j) to load impedance, while rectangular FSS with dual hybrid substrates (Rogers RO3010 + Glass) with dual FSS has the highest resistive effect of (0.795i + 0.183j) to the load impedance. Also trapezoid FSS on dual hybrid substrates (FR4 + Glass) has highest capacitive effect of (0.886i + 0.324j) to the load impedance. These results help in achieving the matching for the materials in order to reduce the losses and to enhance the performance of signal power in wireless system.
Juice Jacking: Security Issues and Improvements in USB Technology

For a reliable and convenient system, it is essential to build a secure system that will be protected from outer attacks and also serve the purpose of keeping the inner data safe from intruders. A juice jacking is a popular and spreading cyber-attack that allows intruders to get inside the system through the web and theive potential data from the system. For peripheral communications, Universal Serial Bus (USB) is the most commonly used standard in 5G generation computer systems. USB is not only used for communication, but also to charge gadgets. However, the transferal of data between devices using USB is prone to various security threats. It is necessary to maintain the confidentiality and sensitivity of data on the bus line to maintain integrity. Therefore, in this paper, a juice jacking attack is analyzed, using the maximum possible means through which a system can be affected using USB. Ten different malware attacks are used for experimental purposes. Various machine learning and deep learning models are used to predict malware attacks. An extensive experimental analysis reveals that the deep learning model can efficiently recognize the juice jacking attack. Finally, various techniques are discussed that can either prevent or avoid juice jacking attacks.
Stakeholder value creation: A case of the hospitality industry

The aim of this study is to understand whether the current literature deals with the general issue of stakeholder value creation and of specific marketing activities for human resources and if they can generate value for different stakeholders. In order to achieve this goal, the paper uses a bibliometric analysis that determines the conceptual structure of the topic, highlighting its evolution over time. Accordingly, this study uses the precise context of the hospitality industry since human resources are of strategic importance in the world of hospitality. This paper opens up a series of considerations, extremely useful within the context of stakeholder value creation in orienting marketing research in the future. In particular, the main findings reveal that with regard to stakeholder value creation only open-to-society marketing can be useful and successful, in contexts of a win-win situation for the sustainable shared advantage
Activation of STAT and SMAD Signaling Induces Hepcidin Re-Expression as a Therapeutic Target for β-Thalassemia Patients

Iron homeostasis is regulated by hepcidin, a hepatic hormone that controls dietary iron absorption and plasma iron concentration. Hepcidin binds to the only known iron export protein, ferroportin (FPN), which regulates its expression. The major factors that implicate hepcidin regulation include iron stores, hypoxia, inflammation, and erythropoiesis. When erythropoietic activity is suppressed, hepcidin expression is hampered, leading to deficiency, thus causing an iron overload in iron-loading anemia, such as β-thalassemia. Iron overload is the principal cause of mortality and morbidity in β-thalassemia patients with or without blood transfusion dependence. In the case of thalassemia major, the primary cause of iron overload is blood transfusion. In contrast, iron overload is attributed to hepcidin deficiency and hyperabsorption of dietary iron in non-transfusion thalassemia. Beta-thalassemia patients showed marked hepcidin suppression, anemia, iron overload, and ineffective erythropoiesis (IE). Recent molecular research has prompted the discovery of new diagnostic markers and therapeutic targets for several diseases, including β-thalassemia. In this review, signal transducers and activators of transcription (STAT) and SMAD (structurally similar to the small mothers against decapentaplegic in Drosophila) pathways and their effects on hepcidin expression have been discussed as a therapeutic target for β-thalassemia patients. Therefore, re-expression of hepcidin could be a therapeutic target in the management of thalassemia patients. Data from 65 relevant published experimental articles on hepcidin and β-thalassemia between January 2016 and May 2021 were retrieved by using PubMed and Google Scholar search engines. Published articles in any language other than English, review articles, books, or book chapters were excluded.
A new high-performance AC/DC power factor correction switching converter based on one-cycle control technology and active floating-charge technology

A new family of converters,high-performance AC/DC power factor correction(PFC) switching converters with one-cycle control technology and active floating-charge technology,was derived and experimentally verified.The topology of a single-phase CCM and DCM Boost-PFC switching converter was also analyzed.Its operating prniciples and control methods were expounded.Based on these,a new type of AC/DC switching converter circuits for PFC combined with one-cycle control technology was presented herein.The proposed AC/DC switching converter significantly helps improve the converter efficiency and its power factor value.