Miracle-dz/UniFAR-FTUs huggingface dataset:
Erythrinin C, From The Root of Pueraria Peduncularis, is a Potential Antagonist Against DHODH, A Therapeutic Target in Acute Myeloid Leukemia: An In Silico Study

Acute myeloid leukaemia (AML) is the second most common form of leukaemia with an annual incidence of 3.6 per 100,000 adults in the United States. A 5-year survival rate of a person with AML is less than 50%. Myeloid leukemogenesis has been reported to arise by a differentiation arrest at early progenitor stage of hematopoietic maturation of the bone marrow; this has led researchers to identify the human dihydroorotate dehydrogenase (DHODH) to be a therapeutic target in the differentiation therapy for AML. Several inhibitors of DHODH have been developed; however only a few have reached clinical trials of which include Brequinar, a strong DHODH inhibitor. Brequinar has reached a phase 2 clinical trials, however, several complication and toxicities have been reported in phase 1 clinical trials in patients with solid tumours. This ranges from myelosupression, thrombocytopenia, nausea, vomiting, skin rashes, mucositis, and this limit its use in AML. In view of this, research is focused on identifying potent DHODH inhibitors with little or no toxic effect that can be used in the differentiation therapy of AML. Pueraria peduncularis belongs to the Leguminosae family and it is widely distributed in some parts of China, India, Pakistan, Nepal and Burma. A recent study has accessed and reported that flavonoids from root of Pueraria peduncularis have anti-tumour effects against cancer cell lines. The aim of this study was to analyse flavonoids from (plant source) root of Pueraria peduncularis for their DHODH inhibitory potential via computational docking studies. For this, four (4) flavonoids (phytochemicals), as well as the DHODH co-crystallized inhibitor, BAY 2402234 which serve as the standard in the present study, were retrieved from the literature and screened for their inhibitory effects on DHODH. Erythrinin C was the lead compound with a binding energy of -11.395kcal/mol. Computational docking and scoring analysis were performed using Lead Finder tool implemented in Flare software of Cresset Inc. (2019, Litlington, UK). The target was validated to ensure that the right target was used for this analysis.
High Reliability Downlink MU-MIMO: New OSTBC Approach and Superposition Modulated Side Information

In this paper a proposal to improve the reliability of a downlink multiuser (MU) MIMO transmission scheme is investigated with the use of a new approach in orthogonal space-time block codes (OSTBC) and network coding with a superposition modulated system and side information. With the new encoded OSTBC approach, diversity is offered where each user receives all other users’ symbols, which allows the recovery of symbols in several ways. In addition, multiple users can be accommodated with the same resource, which is quite useful in a wireless system where resources are always restricted. By employing superposition modulation, the side information needed for error recovery can be transmitted over the same resource used for the normal information frame. In addition, the proposed system exploits diversity through a novel technique of sub-constellation alignment-based signal combining for efficient side information dissemination. A detailed analysis of the new OSTBC approach is carried out. It is shown that the performance of the MU-MIMO system can be improved significantly in terms of block and frame error rates (BLER, FER) considered as reliability measures. By accommodating a reasonable number of multiple users, high reliability is achieved at the expense of the rate. To compensate for the low rate, conventional OSTBC can be considered and simulation results are shown, where, as a penalty to pay, multiple orthogonal resources are required.
ANALISIS KERUSAKAN DNA PADA SEL LIMFOSIT PASIEN PASCA-RADIOTERAPI

Analyses of DNA Damage in the Patient’s Lymphocyte Cells Post-Radiotherapy Radiotherapy given in high doses to kill cancer cells can also induce DNA damage in surrounding normal cells. The radiation dose is divided into smaller doses called fractionation to decrease the effect of radiation on normal tissue. For this reason, it is necessary to monitor the peripheral blood lymphocytes to evaluate the patient's DNA damage. The alkaline comet test is a simple and sensitive technique for detecting DNA instability. This study involved 11 patients who underwent radiotherapy up to 20 Gy, and 11 healthy subjects as controls. This study aims to see how much DNA damage is caused by a 20 Gy fractionated radiation dose in patients with various cancers. The results showed that the mean frequency of damaged cells in patients was 80.54 ± 12.52% with a mean comet tail length of 49.98 ± 12.93 µm. There was a significant difference in both the frequency of damaged cells and the mean value of the comet tail length against the control group (p < 0.001). It was concluded that high doses of radiation can cause DNA damage to peripheral blood lymphocytes. Radioterapi yang diberikan dalam dosis tinggi untuk mematikan sel kanker juga dapat menginduksi kerusakan DNA pada sel normal di sekitarnya. Dosis radiasi dibagi menjadi dosis yang lebih kecil yang disebut fraksinasi untuk menurunkan efek radiasi pada jaringan normal. Untuk itu perlu pemantauan pada limfosit darah tepi untuk mengevaluasi kerusakan DNA pasien. Uji komet alkali merupakan teknik yang sederhana dan sensitif untuk mendeteksi ketidakstabilan DNA. Penelitian ini melibatkan 11 pasien yang menjalani radioterapi hingga 20 Gy, dan 11 subyek sehat sebagai kontrol. Penelitian ini bertujuan untuk melihat seberapa besar kerusakan DNA akibat dosis radiasi fraksinasi 20 Gy pada pasien dengan variasi kanker. Hasil penelitian menunjukkan bahwa rerata frekuensi sel yang rusak pada pasien 80,54 ± 12,52% dengan rerata panjang ekor komet 49,98 ± 12,93 µm terdapat perbedaan nyata baik pada frekuensi sel yang rusak maupun nilai rerata panjang ekor komet terhadap kelompok kontrol (p < 0,001). Penelitian ini menyimpulkan bahwa radiasi dosis tinggi dapat menyebabkan kerusakan DNA sel limfosit darah tepi.
SOCIO-ECONOMIC BENEFITS OF THE PARIS REGION POLICY, BALANCED BETWEEN TRAFFIC MANAGEMENT AND INFORMATION

Road information aims to change driver behavior. Before any trip begins, the driver must determine transportation mode, departure time, and route. The 600-km network of expressways in the Paris region, with its dense implementation of a control and information system called SIRIUS, is an ideal test-bed to measure and follow changes in driver behavior over a long period of time. The safety issues as well as the diversion options are discussed according to the last surveys. A step-by-step implementation of a large amount of variable message signs, first, then in-car information or route guidance devices, makes it possible to isolate the main parameters that are likely to trigger actual modifications. These modifications can only occur when the different choices are made available via a consistent array of reliable and timely traffic information. Even then, it is crucial to establish the first hypothesis about how the public will react to through traffic information: will they stick to their habits or not, and in what proportion?
Is Technological Change Really Skill Biased? Evidence from the Introduction of ICTs on the Textile Sector (1980-2000)

This paper investigates the effects of the introduction of information and communication technologies (ICTs) on the skills of a workforce. Using micro-data collected from workers in the textile sector, we analyse whether the introduction of ICTs has modified workers’ tasks, so that higher skills and longer training periods than before are necessary. Our survey has shown that ICTs i) have replaced unskilled labour in some cases and skilled labour in others; ii) have changed workers’ tasks in some cases but not in others; and finally, iii) have brought about an increase in skills for only a small number of occupations. This empirical evidence does not confirm the hypothesis that technological change, and in particular change introduced by ICTs, is necessarily skill biased
Analysis of the Temperature impact on Reliability of GaN-based Light Emitting Diodes

This thesis reports the results of the three-year research activity on Light Emitting Diodes (LEDs) for Solid State Lighting. In particular, the research project was focused on the study of thermal characterization of Gallium Nitride (GaN) based LEDs, and the impact of the temperature on the reliability of devices. The work starts from an overview of the State of the art of III-V optoelectronic devices and on reliability aspects of such devices. Afterwards, different characterization methods for thermal characterization of LEDs are presented and discussed with the description of some experimental implementations designed. In the remaining chapters three reliability approaches on different LED structures are presented: (i) an Accelerated Lifetime Testing (ALT) on low-flux Phosphors Converted LEDs, (ii) an ALT on High Brightness LEDs with Chip-on-Board technology, and (iii) a reliability analysis on Deep UV AlGaN-LEDs. In all case studies, the thermal aspects have been stressed in the analysis of the results. The different activities started from an in-depth knowledge of the device structure and the related issues, and aimed at (i) extrapolating the degradation model that can provide an accurate lifetime estimation, (ii) investigating on physical mechanisms responsible for degradation, (iii) finding a correlation between thermal behaviour and reliability. The present work permitted to collect new results concerning the mechanisms that still limit the reliability of LEDs, and will provide the experimental and analytical tools suitable for ALT design and implementation.
Pattern of Genetic Diversity of Feral domestic cat populations in Lamu, Kenya and Iran suggest possible influence of historical trade between Persian Gulf and East African Coast

Background: During Early Indian Ocean trade, many species of animals were transported along the routes and destinations especially in eastern Africa. The influence of this historical trade on genetic relationships of historically popular pets such as domestic cats, in East African Coast and Persian Gulf has never been evaluated. Herein, we analyzed variation in mitochondrial DNA sequences from one African wildcat together with 59 feral and domestic cats from East African coastal-Lamu (EAC-Lamu) (n=41) and Iran (n=18) to evaluate possibility of exchange of these animals during the historical trade. Results: From this analysis, all ND5 & ND6 sequences of EAC-Lamu and Iranian cats can be assigned into one haplogroup. The haplotype sharing pattern between these two regions is detected in the network. The whole genome analyses reveal cats from EAC-Lamu and Iran cluster into one branch whereas other cat breeds cluster separately into other branches. The demographic history inference further confirms the relationship between EAC-Lamu and Iranian indigenous cats split around 2,800 years ago, followed by gene flow as a result of human activities.Conclusions: Our results unveil the diversity and existing relationship between indigenous cats from Iran and EAC-Lamu due to historical trade. The current data do not permit us to make further conclusions; therefore, more research evidence from genetics and archaeology may provide further insights into the direction of genetic influence of this historical trade.
A MEMS-based, high-resolution Electric-Field meter

In MEMS-based inertial sensors, such as accelerometers and gyroscopes, known electrical waveforms are applied to a modulating capacitive element to determine an unknown deflection. However, the inverse of this scheme can also be exploited the capacitive element can be deterministically modulated to measure an electrostatic variable. This thesis presents the design, analysis, and evaluation of such a sensor -a MEMS-based, high-resolution electrostatic field-meter (ESF) using the Analog Devices iMEMS process. High-resolution sensing is achieved by optimizing the interface electronics for low-noise operation and applying feedback techniques to enhance the range-of-motion of the MEMS capacitive structure. The entire system consists of three components: the MEMS capacitive structure and two circuit subsystems the sense block and the drive loop. The MEMS structure acts as a transducer to generate a dynamic current that is proportional to the magnitude and polarity of the electric field incident on the sensor. The drive loop is a closed feedback loop that modulates the MEMS capacitive structure at its resonant frequency to maximize its displacement and the magnitude of the dynamic current. The sense block ultimately converts the dynamic current into a dc voltage that is proportional to the magnitude and polarity of the incident electric field. The critical, front-end component of the sense block, a transimpedance amplifier, is implemented with a low-noise operational amplifier for optimum sensing resolution. Thesis Supervisor: Kent H. Lundberg Title: Post-Doctoral Lecturer Thesis Supervisor: Timothy A. Denison Title: Design Engineer, Analog Devices Thesis Supervisor: Michael W. Judy Title: Fellow, Analog Devices
Disentangling the facilitating and hindering effects of threat-related stimuli – A visual search study

Although large body of research has demonstrated the attention-grabbing nature of threat-related stimuli, threat could also facilitate attentional processes. Previous studies suggestalinearrelationshipbetweenthefacilitatingeffectofthearousallevelconveyedbythreatandperformanceonvisualsearchtasks.Duetothetemporalcompetitionbiasfavouringstimuliwithhigherarousallevel,thiscouldbemorepronouncedforshorter onset times. Here, through two experiments we aimed to disentangle the two effects by using a visual search paradigm that allowed us to separate the emotional stimuli and the cognitive task. We manipulated stimulus onset time and threat intensity. Participants saw neutral and threatening pictures as priming stimuli, and then, they had to ﬁnd numbers in ascending order in a matrix array. We measured the reaction time for ﬁnding the ﬁrst number, and search time for ﬁnding all the numbers. Our results showed that when the priming stimulus is presented, longer threatening pictures produced longer reaction times compared to neutral ones, which was reversed with increase in arousal. We did not ﬁnd any signiﬁcant effects for the shorter onset time. Further theoretical and methodological implications are discussed.
PSO based Directional Relay Parameter Tuning for Smart Grid Systems Protection

Power system grid are upgraded by enhancement of directional over-current-relays (DOCRs) setting is a basic issue in electrical designing. The smart grid advancement model of the issue end up being non-direct and rather controlled wherein setting especially time dial setting (TDS) and plugging setting (PS) of each hand-off are set over a choice factors; the total of the working on all the essential transfers, which are anticipated to work that enable to clear the issue in their relating zones, considered as main objective. In the predominant analyze, demonstrate thought about especially IEEE eight-bus power syatem. To comprehend the problem, we have connected PSO based smart mechanism to upgrade the normal power system grid to smart grid. The outcome are a contrasted and the traditional arrangement of intelligent guideline followed by relays; the numerical outcome demonstrate that the changed calculation outflank or perform at standard with different calculations. In light of the intelligent coordination result acquired on the investigations, the proposed optimized enhancement set of principle can be utilized to compute the setting of the directional overcurrent transfer in a distribution community with allotted generation demand of smart grid. The proposed set of rule has shown to have the potential to keep selectivity among the relay being coordinated and limit the running time of the primary relay for close-in 3-phase faults.
A Modified Square Patch Antenna with Rhombus slot for High bandwidth

In this the proposed patch antenna operates at 32 GHz which is among the projected 5G communication frequencies and has a novel geometry with rhombus-shaped slots. The first design in this work is a inset fed used conventionally in patch antenna. It has a quarter wavelength impedance matching line. The dimensions are determined according to the usual design considerations. Low return loss and high bandwidth requirements motivates us to modify the antenna design. Therefore, we add rhombus – shaped slots on the patch which leads to an additional increase in the system bandwidth as much as 52 MHz and a reduction in the return loss level up to 11.241 dB. The proposed patch antenna design is conjectured to be a suitable candidate to address the requirements of 5G communication systems. The operating frequency of the proposed antenna can be tuned by changing the geometrical dimensions from microwave to the THz region.
Combinations of Quantitative Methods in the Forecast for Demand for Sales of Home Appliances

1. Via do Conhecimento, s/n KM 01 Fraron, Pato Branco PR, 85503-390, engqmc_wilian@hotmail.com; 2. donizetti@utfpr.edu. br; 3. marcelo@utfpr.edu. br FERRO, W.A. ; LIMA, J.D. ; TRENTIN, M.G. Combinações de Métodos Quantitativos na Previsão de Demanda de Vendas de Eletrodomésticos. GEPROS. Gestão da Produção, Operações e Sistemas, v. 14, n. 5, p. 67 88, 2019. GEPROS. Gestão da Produção, Operações e Sistemas, Bauru, Ano 14, no 4, out-dez/2018, p. 1-23. DOI: 10.15675/gepros.v13i4. 1965 Editor Responsável: Prof. Dr. Hermes Moretti Ribeiro da Silva GEPROS. Gestão da Produção, Operações e Sistemas, v. 14, no 5, p. 67 88, 2019.
Volleyball : steps to success

Score more points with solid fundamentals. Volleyball: Steps to Success provides expert instruction and 99 drills to help you learn and master the basic skills and strategies. By following the book's sequential lessons and studying the 193 illustrations, you'll learn why each skill is important in a competitive setting and how to analyze and correct errors. The drills come with performance goals and a list of key points to remember when executing each drill, and they often include instructions for increasing or decreasing the difficulty of the drill. Part of the highly popular Steps to Success Activity Series, this book will help you develop the skills and confidence you need to compete and win.
SIMULASI MODEL INDOOR CEILING MOUNT ANTENNA SEBAGAI PENGUAT SINYAL WI-FI MENGGUNAKAN SIMULATOR ANSOFT HFSS V10.0

Abstrak Indoor Ceiling Mount Antenna merupakan salah satu antena Omni Directional yang sangat pesat perkembangannya dalam sistem telekomunikasi dan salah satu aplikasinya dipakai sebagai penguat sinyal Wi-Fi ( Wireless Fidelity ) di dalam ruangan (indoor). Adapun penggunaan antena ini dapat mengakses jaringan wi-fi dari ruang kelas ke seluruh ruangan kampus atau dari kantor ke kantor yang berlainan dan antar gedung. Paper ini membahas tentang cara mensimulasikan sebuah antena Ceiling Indoor dengan model no:YLXD-08/25-3M yang bekerja pada pita frekuensi 1710-2500 MHz, gain 4 dBi, VSWR ≤ 1,5 dan impedansi masukan 50 Ω yang dimodelkan dengan menggunakan simulator Ansoft HFSS v10.0. Dari hasil simulasi diperoleh gain sebesar 5,17 dBi dan VSWR sebesar 1,37 serta hasil perhitungan secara teoritis diperoleh gain sebesar 3,62 dBi dan VSWR sebesar 1,45. Kata Kunci: Antena Ceiling Indoor , Antena Horn Konikal , Wi-Fi
CXCL12, A Potential Biomarker and A Vital Modulator of Tumor Immune Microenvironment (TIME) of Bladder Cancer: From A Comprehensive Analysis of TCGA Database

Background: Tumor immune microenvironment (TIME) played a significant role in the initiation and progression of bladder cancer (BC). However, there are few researches regarding the association between immune-related genes (IRGs) and tumor-infiltrating immune cells (TICs) in TME of BC. Methods: We calculated the proportion of immune/stromal component and TICs in TME of 414 BC samples and 19 normal samples downloaded from The Cancer Genome Atlas (TCGA) database with the help of ESTIMATE and CIBERSORT algorithms. Differentially expressed genes (DEGs) were obtained from the comparison between Stromal and Immune Score and further analyzed by GO and KEGG enrichment analysis, as well as protein–protein interaction (PPI) network and COX regression analysis. CXC chemokine ligand-12 (CXCL12) was overlapping from the above analysis. Afterwards, single gene analysis of CXCL12 was carried out through difference analysis, paired analysis and Gene Set Enrichment Analysis (GSEA). The association between the expression of CXCL12 and TICs was assessed by difference analysis and correlation analysis.Results: The results indicated that immune and stromal component in TME of BC were associated with patients’ clinic-pathological characteristics. We further confirmed that 284 DEGs were primarily enriched in immune-associated activities and CXCL12 was the most significant gene, which shared the leading nodes in PPI network and closely related with BC patients’ survival. Single gene analysis revealed that CXCL12 was down-regulated in BC samples and significantly related with the clinic-pathological characteristics of patients. Further analysis indicated that CXCL12 greatly participated in immune-associated activities through closely communicating with TICs in TIME of BC.Conclusions: CXCL12 might be a potential biomarker and a vital modulator of TIME through communicating with multiple TICs, which might provide an extra insight for the immunotherapy of BC.
SISTEM PENCARIAN RUTE ALTERNATIF DINAMIS DENGAN SMART ROUTING SYSTEM MENGGUNAKAN A* ALGORITHM BERBASISKAN WEB

Routing adalah suatu proses pencarian jalur alternatif yang dapat dilalui oleh user dengan mempertimbangkan jarak terpendek, biaya yang dikeluarkan, serta efektifitas waktu tempuh. Routing dibutuhkan oleh seorang pengguna jalan ketika akan bepergian. Dengan memasukkan lokasi awal dan lokasi tujuan, sistem routing akan secara otomatis memberikan informasi jalur yang dapat dilalui, sehingga user dapat terhindar dari kemacetan dalam perjalanan. Sistem routing yang dikerjakan pada Tugas Akhir ini mempunyai kemampuan akses melalui web. Untuk itu, penulis menggunakan engine MapServer yang memadukan fungsi map dan web server sekaligus. Pada MapServer, data peta di simpan dalam postgreSQL. Agar dapat melakukan routing, dalam database di de_nisikan fungsi A* menggunakan engine pgRouting. Pengujian dilakukan untuk satu lokasi awal menuju 14 titik lokasi tujuan yang tercantum pada tampilan peta kota Surabaya di dalam web. Hasil pengujian menunjukkan jarak tempuh yang harus di lalui oleh user dari lokasi awal, menuju lokasi tujuan tertentu yang dimasukkan user, serta menunjukkan nama - nama jalan yang harus di lalui agar dapat sampai ke lokasi tujuan dengan jarak yang paling pendek.
VALIDACIÓN EMPÍRICA RESIDUAL CON USO DE SIMULACIÓN PARA EVALUAR CONVERGENCIA DE ALGORITMOS DE OPTIMIZACIÓN EN CALL CENTERS

RESUMEN La optimización de Call Centers no es un problema fácil de resolver, debido a la complejidad de los modelos matemáticos que derivan de las fórmulas de Erlang. Esta complejidad se traslada a modelos de optimización, que en la mayoría de los casos, se conforman con funciones objetivos no lineales y no derivables. Así como en todas las áreas de la Investigación de Operaciones, resolver estos problemas demanda algoritmos eficientes, rápidos y precisos. La Simulación como herramienta experimental constituye un ambiente esencial para la validación de algoritmos de optimización, sobre todo cuando no se dispone de repositorios de problemas bien definidos con métricas de resultados conocidos con los que se pueda contrastar. En este trabajo se presenta una estrategia denominada validación empírica residual mediante el uso de simulación para dar credibilidad estadística de la convergencia de algoritmos de optimización no lineal entera en el estudio de los problemas de Call Centers.