Miracle-dz/UniFAR-FTUs huggingface dataset:
The “7+3” regimen in acute myeloid leukemia

Nowadays, the majority of patients with acute myeloid leukemia (AML) achieve a complete remission and many are cured. This remarkable achievement takes place with a standardized induction regimen consisting of an anthracycline and cytarabine. The landmark paper in 1973 – from the prestigious USA group of James Holland at the Roswell Park Memorial Institute in Buffalo, New York – reported on an astounding complete remission rate of 63% among patients with both previously-treated and previouslyuntreated AML. The drugs used were the anthracycline, daunorubicin (formerly rubidomycin in France and daunomycin in the USA), and the pyrimidine antimetabolite, cytosine arabinoside. For a decade prior to this work, each of these drugs was shown to have potent anti-leukemic activity as single agents and even combinations of these two drugs had been reported. In all cases only a small number of remissions were achieved and they were of very short duration. The ultimate breakthrough came, not with the addition of new drugs, but after longer exposure of the leukemic cells to the combination of daunorubicin and cytarabine, as cytosine arabinoside is now known. This breakthrough combination and schedule of drugs for AML, widely known as the “7 and 3” regimen, dramatically changed the prognosis of patients, has remained the backbone of standard therapy for close to five decades, and, amazingly, is still going strong. This remarkable development has been at the core of the current constantly improving outlook for newly-diagnosed patients with AML. From having an incurable disease in the early 1970s, approximately 35-40% of young adults can now expect to be long-term survivors – after starting with “7+3” induction therapy. Furthermore, and quite unthinkably even two decades ago, patients tolerate this combination well into their seventies.
COVID like illness versus COVID-19 (CLIC STUDY) – Clinical profile and outcome

Background: In December 2019, several cases of acute respiratory illness were detected in Wuhan city of China. This SARS-CoV-2 has been rapidly spreading worldwide ever since. SARS-CoV-2 has the potential to damage the vital organs such as lung, heart, liver, and kidney, and infection poses a considerable risk to patients by the high prevalence of pneumonia. Aims and Objectives: The objectives of the study are as follows: (1) To study clinical profile and biochemical markers in SARI patients. (2) To compare the clinical profile and biochemical markers between SARS-CoV-2 positive and negative patients and their outcomes. Materials and Methods: The present study is a hospital-based prospective cross-sectional study conducted on a total of 350 patients (150 SARI+200 COVID-19) in Bengaluru during the study period from June 2020 to May 2021. Results: Diabetes mellitus was present in 30% of SARI and 42% in COVID-19 patients (P=0.03). Leukocytosis (Total Leukocyte Count [TLC] >11000 cells/mm3) was more common among SARI patients than COVID-19 patients (49.3% vs. 24.3%). Leukopenia (TLC <4000 cells/mm3) was significantly more common in COVID-19 patients than in SARI patients (10.2% vs. 3.6%, P<0.001). Conclusion: COVID-19 infection is more common in patients with comorbidities such as diabetes mellitus and hypertension than SARI. Leukopenia was more common in COVID-19 patients whereas leukocytosis was more common in SARI patients.
A Multi-Objective Mathematical Model for Green Supply Chain Reorganization

This study considers a green supply chain design (GrSC) with environmental concerns. We develop a multi-objective mathematical mode for hub location allocation problem that captures the trade-off between our objectives. The first objective is related to the total cost: transportation & inventory cost and the second one is related to the environment impact, such as CO 2 emission. The strategic decisions considered in the proposed model define which warehouses should be selected as a distribution center (hub) and what transportation mode and organization which number of vehicles are required to move products in each period among suppliers, distribution center and warehouses. a new resolution process is proposed and meta-heuristic approach is applied to obtain Pareto frontier.
Effect of Multiple Resource Competition on Driving Performance Using an In-Vehicle Information System

The present study aims to clarify how four different combinations of input and output resources affect driving performance, because usage of information devices based on non-visual and non-manual interface during driving is configured as distracter recently. The primary task consisted of following a lead vehicle at a constant headway while that vehicle changed speed according to a predefined rhythm. The secondary task, which involved using a surrogate user interface, consisted of four different tasks to assess interference with the driver’s attentional resource during driving. To achieve the objective, we conducted a field experiment on a test track using 14 participants. The results suggest that the smallest effects on driving-relevant metrics were for the combination of auditory stimuli and verbal response, and that the greatest effects were for the combination of visual stimuli and manual response.
Annular Pancreas in Neonates; Case Series and Review of Literatures

Background: The annular pancreas is a rare congenital disorder of the pancreas first recognized in 1818. It is believed to result from faulty rotation of the ventral pancreatic bud in its course around the posterior aspect of the duodenal anlage. The duodenum is encircled and might be obstructed by normal pancreatic tissue. The management of the annular pancreas is still developing and under revision. Case Presentation: Six cases of neonatal intestinal obstruction secondary to the annular pancreas diagnosed, operated on, and involved in our study. Age, gender, maturity, age at referral, birth weight, clinical presentation, imaging findings, associated congenital anomalies, treatment, complications, and hospital stay were all studied. Polyhydramnios is found in 3 cases (50%). Down syndrome was diagnosed in one case. One patient has associated malrotation. Symptoms started earlier within the first 24 hours. Vomiting was bile stained in 4 cases (66.7%). Passing meconium, sometimes frequent, does not exclude the annular pancreas. Most patients show double bubbles sign on plain abdominal X-ray. All six neonates were treated with duodenoduodenostomy with excellent results. Survival was 100% and complications were minimum. Conclusion: The annular pancreas, although rare, is an important cause of neonatal duodenal obstruction. The accurate diagnosis is usually performed during laparotomy. Vomiting may contain bile or not, furthermore, passing meconium does not exclude this condition. The best and the excellent surgical option is diamond duodenoduodenostomy. This case series might be added to the registered cases of the annular pancreas to standardize the method of diagnosis and to define the best management.
Guidance Manual for Separation of Graywater from Blackwater for Graywater Reuse

Increasing efforts in water conservation have prompted home and business owners to learn more about water reuse. One reuse application of interest is separating graywater (all wastewater excluding kitchen and toilet water) from other wastewater to supplement irrigation demand or toilet flushing. Some states including California, Arizona, New Mexico, Nevada, and Texas already allow graywater reuse and many other states are considering it. But graywater reuse is not right for every situation; it is vital to safely separate graywater from blackwater using a dual plumbing system. This manual provides guidance on the appropriateness of graywater reuse for homeowners and business owners system. For those homes and business that are good candidates, this manual provides information, guidance and advice on separating graywater from blackwater for the purpose of graywater reuse. Included in this manual are the technologies and equipment necessary for graywater reuse systems, known maintenance requirements for graywater systems, and best management practices to ensure safe reuse of graywater. This title belongs to WERF Research Report Series . ISBN: 9781780400082 (eBook)
Woody Species Composition, Diversity And Structure of Vegetation of Peri-Urban Park in Leo, Burkina Faso

This work aims to fill a gap in knowledge of the Burkina Faso Southern Sudanese flora and vegetation. The woody vegetation of the forest park of the Scholl Complex in Léo comprises a total of 26 families, 63 genera and 81 species including native and introduced ones. The fallow is the unit that contains all families and genera and 93% of species. The most abundant species of units of the Park are Terminalia avicennioides (Combretaceae), Piliostigma thonningii (Fabaceae-Caesalpinioideae), Daniellia oliveri (Fabaceae-Caesalpinioideae), Vitellaria paradoxa (Sapotaceae), Detarium microcarpum (Fabaceae-Caesalpinioideae), Diospyros mespiliformis (Ebenaceae), Annona senegalensis (Annonaceae) and Pteleopsis suberosa (Combretaceae). The species that regenerate the most and that will ensure the sustainability of the peri-urban forest resources are Gardenia erubescens (Rubiaceae), Piliostigma reticulatum (Fabaceae-Caesalpinioideae), Vitellaria paradoxa, Annona senegalensis, Terminalia avicennioides (Combretaceae), Diospyros mespilifomis and Azadirachta indica (Meliaceae). The most threats on vegetation and flora of the School Complex are fraudulent human exploitation, parasitic pressure and progressive intrusion of Azadirachta indica.Peri-urban park resources conservation measures concern the replanting of vegetation in degraded areas and incentives for wood production for local populations. A management program for threatened or rare species, control of invasive alien plants and domestic animals and the development and improvement of habitat to create a future urban park.
Vibrotactile feedback for application on mobile touch screen devices : effects with age

This thesis has investigated vibrotactile interactions for touch screen devices related to age, the study developed distinguishable vibrotactile patterns for evaluation by younger and older people, in order to inform the design process for the development of a haptic language. The study of haptic perception validated that the optimal sensation to vibration for both age groups is in the range of 100-300 Hz, which guides the design of the future vibrotactile patterns development. As part of the human perception study carried out, it was found that two of the seven semantic differential pairs tested, ‘slow-fast’ and ‘light-heavy’, are suitable to describe the feelings of haptic feedback for younger people however there was no clear agreement for older people. It is recommended that the magnitude estimation techniques can be used for the future experimental design. Finally, this study shows that haptic language could be developed using vibration with the respect to the parameters of amplitude, frequency, and frequency ramping. The amplitude of vibration plays a key role in determining whether people can adequately sense the message, whereas the frequency can be used to imply meaning. The study found that a signal at 200 Hz could be understood to have a positive meaning for the vibrotactile interaction. Frequency ramping could be an essential parameter to design a negative vibrotactile interaction, compared to amplitude ramping that has no significant influence for perception. Most people would require a certain level of training to learn a haptic language because humans have no pre- conception of vibrations other than as an alert. It is suggested that a scenario should be provided to the subjects for the valuation.
Evolution of the Next Generation of Technologies: Mobile and Ubiquitous Computing

Mobile and Ubiquitous Computing technologies allow interconnected devices to be embedded unobtrusively in everyday appliances and environments, and to communicate and co-operate to provide information and services on behalf of their human users. The development of Mobile and Ubiquitous computing applications and systems has been identified by many visionaries as a key enabling prerequisite for the evolution of the next generation of technologies. The goal of Ubiquitous computing is to create ambient intelligence where network devices embedded in the environment provide unobtrusive connectivity and services all the time, thus improving human experience and quality of life without explicit awareness of the underlying communications and computing technologies.
Augmented Reality: Navigation und standort- bezogene Dienste mit Android-Smartphones Augmented Reality: Navigation and Location-Based Services Using Android Smartphones

This thesis studies the utilization of augmented reality (AR) on smartphones. A widespread use of augmented reality on smartphones are AR browsers. These browsers allow the user to interact with surrounding points of interest (POI). AR technology still has great unused potential. This thesis envisages the development of an AR-based system, which can be used in such spaces as, for example, an office building. For this purpose, the AR system has to be designed for indoor and outdoor use. In addition it should allow the user to interact with surrounding rooms and people, as well as to navigate both indoors and outdoors. To this end, existing AR systems for Android smartphones have been analyzed and the required components worked out based on the findings of these analyses. It was determined that present systems are not suitable for indoor use, nor do they offer navigation functions. The interaction with POIs is generally limited to certain predefined functions. In this thesis, an AR system has been developed providing navigation as well as interaction with POIs. To improve the flexibility of POI interaction, customizable locationbased services have been developed. The system is suitable for indoor and outdoor use with a smooth transition between these two areas. The indoor suitability is provided through a newly developed Android application, which allows the system to insert new location providers into the Android operating system. In addition an AR browser offering all the above mentioned features, such as navigation and interaction with POIs, has been developed. Furthermore, the AR browser provides the connection to location-based services, which allows the user to interact with rooms and people.
Foamed bioplastics: a review

*Corresponding author e-mail: maciej.combrzynski@up.lublin. pl A b s t r a c t. Based on a literature review, the development and importance of foamed bioplastics in the context of conventional materials has been discussed in the paper. Raw materials, technological aspects, types of products (including a new generation of bioplastics), their advantages and disadvantages as well as user expectations are presented. Despite considerable progress, especially in the formulation of new raw material compositions, there is still a need to continue research work on the application of different techniques in the production of biodegradable porous packaging materials. It still remains the current primary goal – to produce products with physical characteristics that are comparable with those of petroleum based plastic. K e y w o r d s: physical properties, foams, porous materials, bioplastics, starch-based packaging materials
Missing links: Connecting emergency management and the cultural heritage industry

Cultural heritage is a source of community identity and local income, two elements that are necessary in any successful disaster recovery effort.The cultural heritage industry, however, has been historically underprepared for disaster events, as recent events demonstrate. This lack of preparedness may result in the loss of irreplaceable artifacts and lagging recovery efforts. It is time to remedy this lack of preparedness through emergency planning. Although the planning process for cultural institutions is similar to other types of emergency planning, some components are unique.This article outlines the elements of emergency planning particular to cultural heritage institutions and provides guidance for emergency managers and the cultural heritage industry so that they may develop emergency plans.
RECENT ADVANCES IN TRANSFER FUNCTION-BASED SURROGATE OPTIMIZATION FOR EM DESIGN (INVITED)

This article provides a review of transfer function-based (TF-based) surrogate optimization for electromagnetic (EM) design. Transfer functions (TF) represent the EM responses of passive microwave components versus frequency. With the assistance of TF, the nonlinearity of the model structure can be decreased. Parallel gradient-based EM optimization technique using TF in rational format and trust region algorithm is introduced first. Following that, we review the EM optimization using adjoint sensitivity-based neuro-TF surrogate, where the neuro-TF modeling method is in pole/residue format. The adjoint sensitivity-based neuro-TF surrogate technique can reach the optimal EM responses solution faster than the existing gradient-based surrogate optimization methods without sensitivity information. As a further advancement, we discuss the multifeature-assisted neuro-TF surrogate optimization technique. With the help of multiple feature parameters, the multifeatureassisted neuro-TF surrogate optimization has a better ability of avoiding local minima and can achieve the optimal EM solution faster than the surrogate optimizations without feature assistance. Three examples are used to verify the above three methods.
Rational Approach to Children with Drug-Resistant Epilepsy

Epilepsy is one of the most common neurological disorders to affect children, and has its highest incidence in infancy. Approximately one-quarter of children have seizures which are drug-resistant, and place the child at increased risk of cognitive delays, attention, behavior and psychiatric disorders, injury, sudden unexpected death and poor quality of life. This article presents a rational approach to the investigation and management of children with drug-resistant epilepsy.
Uncertainties in Seismic Hazard Maps for the New Madrid Seismic Zone and Implications for Seismic Hazard Communication

Earthquake risk assessment has been described as “a game of chance of which we still don't know all the rules” (Lomnitz, 1989). This challenge is illustrated by attempts to estimate the seismic hazard for parts of the central U.S. due to earthquakes in the New Madrid Seismic Zone (NMSZ). The U.S. Geological Survey National Seismic Hazard Maps predict that the seismic hazard in the area is surprisingly high, in some ways exceeding that in California. These predictions reflect crucial parameter assumptions, many of which have considerable uncertainty due to the absence of instrumental data from any but small earthquakes. Hence we explore the coupled questions of how the predicted hazard depends on various assumptions and how the uncertainties in estimates of hazard might be communicated to scientists, engineers, policy-makers, and others facing the challenge of deciding on seismic safety strategies that balance costs and benefits. At present, most seismic hazard assessment is done using the probabilistic seismic hazard analysis (PSHA) approach developed by Cornell (1968) and widely applied in engineering design ( e.g., Reiter, 1990; McGuire, 1995). An informative and entertaining overview of PSHA is given by Hanks and Cornell (1994). Major studies of seismic hazard in the central and eastern United States, including the NMSZ, were conducted in the 1980's by Lawrence Livermore National Laboratory (Bernreuter et al., 1985) and the Electric Power Research Institute (EPRI, 1986) for application to nuclear power plant licensing. A detailed study of the NMSZ was also carried out for the U.S. Department of Energy for the Gaseous Diffusion Plant in Paducah, Kentucky (Risk Engineering, 1999). Based on these and related efforts, and motivated bythe design and licensing needs of critical facilities, detailed consensus recommendations have been developed for conducting PSHA (SSHAC, 1997). It has become common to apply the PSHA method to …
Multi-sensor Fusion Based Vehicle Detection and Tracking Method

To fulfill real-time vehicle detection and track in city environment,a method based on laser radar and vision was presented.By perspective transform,vehicle hypothesis is done through laser radar.For vehicle recognition aspect,a method based on multi-dimension space Mahalanobis distance is presented,which extracts feature vector in ROI,and using the Mahalanobis distance between it and standard vector as presence probability.In vehicle tracking,the system uses Kalman filter to fulfill target tracking,at the mean time,to improve robustness,a particle-filter method based on Kalman filter is presented,it could realize more precise target state estimation when laser radar data does not work well.The experiment shows this method can achieve better vehicle tracking in general city environment.
Identi cation of a Hypoxia-Related LncRNA Signature for the Prognosis of Colorectal Cancer

Hua Huang Changshu Hospital, Nanjing University of Chinese Medicine Mingjia Gu Changshu Hospital, Nanjing University of Chinese Medicine Shanshan Xu Nanjing University of Chinese Medicine Youran Li A liated Hospital of Nanjing University of Chinese Medicine Yunfei Gu A liated Hospital of Nanjing University of Chinese Medicine Lijiang Ji (  Ji512@163.com ) Changshu Hospital, Nanjing University of Chinese Medicine
Range Ambiguity Smearing and Suppression: Comparison of Different Azimuth Phase Codes and Opportunities from Multi-Focus Post-Processing

Synthetic aperture radar (SAR) remote sensing has become very attractive in Earth observation applications, since it provides high resolution imaging independent of weather conditions and sunlight illumination. However, the design of a SAR system is still constrained by nadir returns and range ambiguities, which can strongly corrupt the quality of the SAR image, if not avoided. Recently, a novel SAR concept, named waveform-encoded SAR, based on pulse-to-pulse variation of the transmitted waveform and on a dual/multi-focus post-processing, has been proposed in order to cope with these ambiguities. While some implementation issues related to waveform variation are still under analysis, this work investigates the potentialities of a thresholding and blanking approach for suppressing range ambiguities and a simpler variant, where waveform encoding is replaced by azimuth phase coding and multi-focus post-processing is always performed. In particular, real TerraSAR-X data are exploited to simulate and assess the range ambiguity smearing capability of a “Doppler-matched” azimuth phase code as well as of a waveform-encoded SAR. First results show that range ambiguity suppression through this approach is only effective for very strong ambiguities.