Miracle-dz/UniFAR-FTUs huggingface dataset:
Profile of Histopathological Type and Molecular Subtypes of Mammary Cancer of DMBA-induced Rat and its Relevancy to Human Breast Cancer

BACKGROUND: Animal models with mammary cancer that closely mimic human breast cancer for treatment development purposes are still required. Induction of 7,12-dimethylbenzanthracene (DMBA) to rats shows the histopathological features and mammary cancer characterization similar to humans. Examinations of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki67 expressions are crucial in deciding the treatment and prognosis of breast cancer. AIM: This research aimed to view histopathology images of mammary glands and expressions of ER, PR, Ki67, and HER2 of DMBA-induced rats. METHODS: After 1-week adaptation, 11 5-weeks-old female rats were induced with 20 mg/kg body weight (BW) of DMBA 2 times a week for 5 weeks. On week 29, nodules taken from the mammary gland were examined for hematoxylin-eosin staining and immunohistochemistry with p63, ER, PR, HER2, and Ki67 antibodies. The grading score used the Nottingham Grading System and molecular classifications based on St. Gallen 2013. RESULTS: Six rats had nodules, but the histopathologic features of one nodule showed normal mammary gland without cancer. The histopathological type of mammary cancer was cribriform carcinoma, comedo carcinoma, lipid-rich carcinoma, adenocarcinoma squamous, and adenomyepithelioma. Histopathological grading showed 60% of grade 3 and 40% of grade 2. P63 expression showed 60% positive and 40% negative. The frequency of ER, PR, HER2, and Ki67 of five nodules showed positivity: 40%, 60%, 60%, and 60%, respectively. Molecular subtypes of Luminal A, B, HER2, and triple-negative were 0%, 60%, 20%, and 20%, respectively. CONCLUSION: Histopathological features and molecular subtype of mammary cancer on rats induced with 20 mg/kg BW of DMBA showed similarity to human breast cancer.
Inibidores de checkpoints imunológicos no tratamento de câncer de pulmão de células não pequenas (NSCLC)

Câncer é uma definição abrangente para se falar sobre mais de 100 tipos de doenças; o câncer de pulmão de células não pequenas (NSCLC) é um dos tipos de câncer mais comuns na sociedade, sendo o que provoca maior mortalidade entre homens e mulheres ao redor do mundo. Em seus estágios mais avançados, o paciente diagnosticado com NSCLC possui uma perspectiva de vida de 1 a 2 anos, sendo necessários tratamentos mais assertivos e que não comprometam a saúde já debilitada desses pacientes. Os quimioterápicos ainda são o tratamento principal de escolha para o tratamento desses pacientes, entretanto o número e gravidade dos eventos adversos oriundos deste tratamento e uma resposta não tão favorável, no que se refere ao aumento da sobrevida desses pacientes impulsiona estudos e pesquisas de novas terapias, a fim de garantir uma resposta cada vez mais eficiente e segura no combate ao NSCLC. Combinações de diferentes terapias, como cirurgia, radioterapia e administração de quimioterápicos seguem sendo analisadas, mas nos últimos anos uma nova classe se juntou à luta: os Imunoterápicos são medicamentos que atuam na ativação ou inibição de algumas respostas do sistema imunológico, promovendo um ataque alvo às células tumorais, preservando as células sadias do organismo.
Anthropomorphic motion control of a gantry robot in assembly cells

Abstract The demand for flexible production systems in which the flexibility at assembly processes is increased by new forms of human-robot collaboration rises. Besides occupational safety the transparency of the robot’s actions and the mental effort are of special importance. Based on the fact that anthropomorphic features of a robotic system can improve its acceptance, anthropomorphic movements of a gantry robot in an assembly cell are compared to conventional point-to-point movements. Results of a study with 20 male participants, in which the influence of these movements of the gantry robot on mental effort, prediction time and prediction accuracy was investigated, are presented in this paper. Results show that the participants could predict the target position of the presented movement significantly faster and more accurately when the gantry robot was controlled by the anthropomorphic motion primitives (α = 0.05). The mental effort ratings show in general reduced values for the anthropomorphic movement, but this effect is statistically not significant.
Silicon based terahertz radiation detectors

This thesis is devoted to study of terahertz detectors based on field-effect transistors fabricated using silicon technology and they comparison to InGaAs/InP ones. The main research effort was devoted to the problem of detectors linearity at high radiation intensities. The photoresponse of field effect transistors to terahertz radiation in a wide range of intensities: from 0.5 mW/cm2 up to 500 kW/cm2 and for frequencies from 0.13 THz to 3.3 THz was studied. This work shows that the photoresponse of all studied detectors increases linearly with increasing radiation intensity up to a few kW/cm2 range and is followed by the nonlinear and saturation parts for higher radiation intensities. This effect has led to the new model of broadband field-effect transistor detectors. The model is based on the phenomenological knowledge of the transistor static transfer characteristic and explains the photoresponse nonlinearity as related to non-linearity and saturation of the transistor channel current. The developed model explains consistently experimental data both in linear and nonlinear regions of terahertz detection.
Phenotypic and Genotypic Detection of Biofilm-Forming Staphylococcus aureus from Different Food Sources in Bangladesh

Simple Summary Biofilm formation by Staphylococcus aureus in foods poses a potential concern for public health and food safety. Therefore, the present study was conducted to detect biofilm-producing S. aureus from foods and human hand swabs using phenotypic and genotypic assays. In this study, S. aureus was detected in 23.81% (100/420) of samples, and among them, 89 and 97 of the isolates were biofilm producers by qualitative and quantitative tests, respectively. At least one biofilm-forming gene was detected in 21 S. aureus isolates, of which four isolates harbored all five adhesion genes (icaA, icaB, icaC, icaD, and bap). In addition, the occurrence of adhesion genes in S. aureus isolates showed a strong significant correlation among themselves. This is the first report on detecting biofilm-forming S. aureus from foods and hand swabs in Bangladesh using the molecular technique. The findings from this study indicate a significant public health risk and suggest the necessity of maintaining food hygiene practices at every step of the food chain to prevent and control S. aureus foodborne illness. Abstract Staphylococcus aureus is a major foodborne pathogen. The ability of S. aureus to produce biofilm is a significant virulence factor, triggering its persistence in hostile environments. In this study, we screened a total of 420 different food samples and human hand swabs to detect S. aureus and to determine their biofilm formation ability. Samples analyzed were meat, milk, eggs, fish, fast foods, and hand swabs. S. aureus were detected by culturing, staining, biochemical, and PCR. Biofilm formation ability was determined by Congo Red Agar (CRA) plate and Crystal Violet Microtiter Plate (CVMP) tests. The icaA, icaB, icaC, icaD, and bap genes involved in the synthesis of biofilm-forming intracellular adhesion compounds were detected by PCR. About 23.81% (100/420; 95% CI: 14.17–29.98%) of the samples harbored S. aureus, as revealed by detection of the nuc gene. The CRA plate test revealed 20% of S. aureus isolates as strong biofilm producers and 69% and 11% as intermediate and non-biofilm producers, respectively. By the CVMP staining method, 20%, 77%, and 3% of the isolates were found to be strong, intermediate, and non-biofilm producers. Furthermore, 21% of S. aureus isolates carried at least one biofilm-forming gene, where icaA, icaB, icaC, icaD, and bap genes were detected in 15%, 20%, 7%, 20%, and 10% of the S. aureus isolates, respectively. Bivariate analysis showed highly significant correlations (p < 0.001) between any of the two adhesion genes of S. aureus isolates. To the best of our knowledge, this is the first study in Bangladesh describing the detection of biofilm-forming S. aureus from foods and hand swabs using molecular-based evidence. Our findings suggest that food samples should be deemed a potential reservoir of biofilm-forming S. aureus, which indicates a potential public health significance.
Normal Approximations with Malliavin Calculus: From Stein's Method to Universality

Preface Introduction 1. Malliavin operators in the one-dimensional case 2. Malliavin operators and isonormal Gaussian processes 3. Stein's method for one-dimensional normal approximations 4. Multidimensional Stein's method 5. Stein meets Malliavin: univariate normal approximations 6. Multivariate normal approximations 7. Exploring the Breuer-Major Theorem 8. Computation of cumulants 9. Exact asymptotics and optimal rates 10. Density estimates 11. Homogeneous sums and universality Appendix 1. Gaussian elements, cumulants and Edgeworth expansions Appendix 2. Hilbert space notation Appendix 3. Distances between probability measures Appendix 4. Fractional Brownian motion Appendix 5. Some results from functional analysis References Index.
Driving–Charging Integrated Controller for Electric Vehicles

Motor driving technology and battery charging technology are the two core technologies of electric vehicles (EVs). They have a profound impact on the performance and mileage of EVs. Based on the topology of a traditional EV motor controller, this study employs the time-sharing multiplexing insulated gate bipolar transistor (IGBT) power module form to expand the functions of the motor controller. This paper proposes an integrated driving–charging controller structure that enables the controller to realize the motor driving and on-board charging simultaneously. A decoupling analysis was performed at the topology level, mathematical models of two bidirectional converters in the integrated topology were established, and a reasonable control strategy for the double-closed-loop control system was designed. The simulation system was built in Simulink, and the simulation results verified the effectiveness of the system topology and control strategy. We made an integrated controller experimental platform based on TMS320F28335. A resistive load simulated the power battery to verify the charging mode, and a 5 kW permanent magnet synchronous motor (PMSM) was used to verify the driving mode. The experimental results demonstrated the driving–charging integrated controller’s feasibility for electric vehicles.
Interpersonal Relationship Stress Brings on Social Networking Sites Addiction Among Chinese Undergraduate Students

The adverse effects of life stress on social networking sites addiction are increasingly recognized, but so far there is little evidence on how and which specific types of life stress are conducive to the addictive behavior. Interpersonal relationship stress being the main source of stress for undergraduates, the purpose of the current paper is thus to delve into whether perceived stress in interpersonal relationships significantly leads to WeChat addiction and, if so, how this type of stress drives the excessive use of WeChat. The data was collected from self-report questionnaires completed by 463 Chinese undergraduate students and then analyzed with structural equation modeling. The results revealed that the positive association between WeChat users’ interpersonal relationship stress and addictive behavior is fully and sequentially mediated by WeChat use intensity and social interaction. More specifically, accumulation of stress in interpersonal relationships gives rise to the intensity of WeChat use, which in turn fuels rising addiction to WeChat both directly and indirectly via social interaction on WeChat. These findings contribute to a more refined understanding of the pathological use of WeChat.
Interlayer‐Incorporation of MoS2 (TM‐MoS2) to Achieve Unique Magnetic and Electronic Properties for Spintronics

The multi‐layer 2D materials have attracted increasing interest because the intriguing properties can be achieved by various strategies, such as incorporating ions into the interlayer, turning angles between two layers, and applying strain, which may lead to wide applications in catalysis, ion‐batteries, superconductors, and nanodevices. In this work, there is a proposal to tune the electronic and magnetic properties of MoS2 bilayer for spintronics by incorporating transition‐metal elements into its interlayer (denoted as TM‐MoS2) based on the density‐functional theory (DFT) calculations. It is shown that TM‐MoS2 is thermodynamically stable and can be achieved due to low incorporation energy. It is found that n‐type doping or intrinsic semiconducting can be realized in MoS2 bilayer by controlling the incorporated transition‐metal atoms, accompanied with a rich variety of magnetic orderings. It is further shown that the electronic and magnetic properties of TM‐MoS2 can be substantially tuned by applying compression. Finally, it is demonstrated that the systems can be used as a spin filter, as supported by the spin‐polarized transport calculation. The findings illustrate that the physical properties of layered materials can be controlled by simple interlayer incorporation and shed light on the application of TM‐MoS2 as a fundamental building block for nanoelectronics and spintronics.
Optimal control strategies of eight parallel heat pumps using Gaussian process emulator

This study describes the development of the optimal control strategies of eight parallel heat pumps in an existing building. The building consists of seven floors above ground and two floors underground with a total floor area of 22,440 m2. The chilled water generated by each of the eight parallel heat pumps runs through a common primary pipe to multiple air-handling units in the building. Because only one flowmeter and two thermometers (entering and exiting) are installed in the primary pipe, the heat removal rate and efficiency of each heat pump are unknown. The existing control of the heat pumps is as follows: if the chilled water return temperature in the primary pipe becomes greater than a predetermined temperature, the controller increases the number of operating heat pumps. The heat removal rate and efficiency of each heat pump were first identified using a Gaussian process (GP) machine-learning algorithm to develop the optimal control strategy of the eight heat pumps. Two GP models, one for estimating the heat removal rate and the other for estimating the coefficient of performance (COP), were developed based on the measured data for 27 days in July at the sampling time of 15 min. After developing the GP models, the authors applied a COP-based sequencing control strategy to the eight parallel heat pumps. The new optimal control strategy is to switch on the heat pumps in order from highest to lowest COP. Compared with the existing control logic, the new optimal control can reduce energy consumption by 20.9%.
EFFECT OF GRAPE SEED FLOUR ON THE PHENOLIC PROFILE, ANTIOXIDANT CAPACITY AND SENSORY PROPERTIES OF MUFFINS

In the study the grape seed flour (GSF) at 7.5% and 15% ratio was blended with wheat flour (W), siyez wheat flour (S) and oat flour (OAT) separately in muffin recipe. The total flavonoid content, total antioxidant capacity, phenolic profile using HPLC-PDA and sensory properties of prepared muffins were determined. Total flavonoid contents of each three muffin were increased significantly (p<0.05) by addition of grape seed flour. Besides, the muffins with OAT had higher total flavonoid content and total antioxidant capacity values than S and W samples. Identified ten phenolic compounds were o-coumaric acid, caffeic acid, gallic acid, phlorizin, kaempherol, trans-resveratrol, (-)-epicatechin, t-cinnamic acid, (+)-catechin and epigallocatechin gallate. W15 muffin was mostly liked, following with S15 and OAT15 according to crust color, odor, and crumbliness characteristics. The GSF used in muffin formulations up to 15% increased nutritional quality and functional properties without adverse effect on sensory quality.
Confronting South Korea's Next Crisis

South Korea’s economic miracle is a well-known story. However, today Korea is confronting a new set of internal and external risks, which may foreshadow the next crisis. The Korean economy has struggled with a faltering growth momentum and the rise of unprecedented socio-economic problems well before the pandemic crisis. After abrupt downshifts to markedly slower growth in the early 2000s, economic growth has continued to decelerate. Koreans are grappling with slow income growth, all time-high household debt, high youth unemployment, inequality, and social polarization. Politics is in disarray and is incapable of directing social discourse for the common good. Rapid population aging along with the world’s lowest fertility rates stokes fears of Japanification. Simultaneously, disruptive technologies and a fast-changing business environment, including the rise of China, clash with a range of long-standing structural problems. The contemporary challenges are radically different from those seen in the early stages of industrialization. There are multiple risks that threaten to self-perpetuate low or stagnant growth over the next decade or so, if not an outright financial crisis. Motivated by these latest developments, this book seeks to provide a timely and in-depth analysis of key current issues and foreseeable challenges of the economy, with a provocative reassessment of its future. Based on extensive new empirical works, it examines the underlying causes of the socio-economic problems. In a constructive spirit, it puts into perspective what would constitute critical elements of ideal policy solutions and the direction of the future government’s role.
Optimal Robust Control of Path Following and Rudder Roll Reduction for a Container Ship in Heavy Waves

This paper presents an optimal approach to the multi-objective synthesis of path following and rudder roll reduction for a container ship in heavy waves. An improved line of sight principle with course-keeping in track-belt is proposed to guide the ship in accordance with marine practice. Concise robust controllers for the course and roll motion based on Backstepping and closed-loop gain shaping are developed. The control parameters have obvious physical significance. The determination method is given and much effort is made to guarantee the uniform asymptotic stability of the closed-loop systems by Lyapunov synthesis. Furthermore, the multi-objective optimization method a fast and elitist multi-objective genetic algorithm (NSGA-II) is used to solve the restrictions caused by the model perturbation, external disturbance and performance trade-off. Contrasting with the existing literature, the research strategy and control performance are more in line with marine engineering practice. Simulation results illustrate the performances and effectiveness of the proposed system.
Association of Received Intergenerational Support with Subjective Well-Being among Elderly: The Mediating Role of Optimism and Sex Differences

Even though an extensive body of previous research has examined the association between received intergenerational support and the well-being outcomes of older adults in a wide variety of contexts, few studies have been conducted to explore the impacts of intergenerational support on elders’ subjective well-being, especially the intermediary mechanisms in this process. The purpose of this study is to fill this gap by exploring the mediating role of optimism in the association between received intergenerational support and subjective well-being among the elderly in China, as well as the sex differences that exist between males and females. The findings show that the intergenerational support received from adult children is positively related to subjective well-being and that this relationship is partly mediated by optimism. Meanwhile, no significant sex difference was found in the interrelations between intergenerational support, optimism, and subjective well-being.
Phase field mechanics of residually stressed ceramic composites

ABSTRACT A phase field theory for crystalline solids accounting for thermoelasticity, fracture, twinning, and limited slip is presented. Residual stresses are incorporated via referencing thermoelastic strain to a reference state that is not always stress-free. Rate dependence, dissipated energy, and residual strain energy (possibly degraded by local fracture) are included in the theory, with physically valid predictions first verified for homogeneous stress states. A variational form of the model is implemented in finite element (FE) calculations of three-dimensional (3-D) polycrystalline aggregates consisting of up to two different crystal constituents and a binding matrix along grain and phase boundaries. Model specifics correspond to constituents of boron carbide-titanium diboride (B C-TiB ) ceramic composites. Effects of thermal-residual stresses incurred during processing, as well as other local microstructure properties and physical features, on deformation and failure mechanisms are revealed. Peak aggregate strengths observed for different boundary conditions demonstrate a pressure-dependent failure surface.
A NOVEL DUAL-PASSBAND NET-SHAPED FSS STRUCTURE USED FOR MIMO ANTENNAS

A dual-passband frequency selective surface (FSS) is designed in this paper. Two passbands are 2–3.4 GHz and 5.5–6.8 GHz, respectively. It is used as a spatial filter to improve the radiation and scattering performance of an antenna. The structure is combined with two layers. One is metal, and the other is intermediate medium. The requirements of wide-band, polarization-independent, wide incidence angle and miniaturized FSS with a thickness of only 0. 0085λ are achieved by parameter optimization. When the FSS is used to the proposed microstrip antenna, the relative bandwidth is increased by 31.4% and 50%, and the peak gain is increased by 2.53 dB and 1.86 dB at 5.8 GHz and 6.4 GHz, respectively. Meanwhile, the maximum RCS reduction of the microstrip antenna is 16 dB. On the other hand, the FSS is able to be applied to a dipole antenna to improve the transmission coefficient and phase. Simulation and measurement results of the transmission coefficient and phase of the antenna are almost the same.