Miracle-dz/UniFAR-FTUs huggingface dataset:
P434. Close rectal versus total mesorectal excision in patients with inflammatory bowel disease undergoing proctocolectomy or completion proctectomy

P433 Canadian patient and caregiver perspectives on subsequent entry biologics / biosimilars for inflammatory bowel disease G. Attara*1, R. Bailey2, B. Bressler3, J. Marshall4, R. Panaccione5, G. Aumais6 1Gastrointestinal Society, Vancouver, Canada, 2University of Alberta, Zeidler Ledcor Centre, Department of Medicine, Division of Gastroenterology, Edmonton, Canada, 3University of British Columbia, Medicine, Division of Gastroenterology, St. Paul’s Hospital, Vancouver, Canada, 4McMaster University Medical Centre, Department of Gastroenterology, Hamilton, Canada, 5University of Calgary, Department of Gastroenterology, Foothills Medical Centre, Calgary, Canada, 6CHUM Centre Hospitalier de l’Université de Montréal, Hôpital Maisonneuve-Rosemont, Medicine, Montréal, Canada
Heart Failure and Short Stature in a 43 year-old male Adolescent Pediatric Kidney Patients Transitioned to Adult Health Care Services through the Philippine General Hospital (PGH) Transition Program ( Lipat Kalinga )

This is a case of a 43-year-old male presenting with short stature and heart failure. The patient was admitted at the medicine ward of the Philippine General Hospital (PGH) for dyspnea. This paper will investigate several issues: differentiating congenital from acquired hypothyroidism, the relationship between hypothyroidism and the cardiomyopathies, and the therapeutic options in patients with cardiomyopathy secondary to hypothyroidism. This is a case of a 43-year-old male presenting with short stature and heart failure. The patient was admitted at the medicine ward of the Philippine General Hospital (PGH) for dyspnea. This paper will investigate several issues: differentiating congenital from acquired hypothyroidism, the relationship between hypothyroidism and the cardiomyopathies, and the therapeutic options in patients with cardiomyopathy secondary to hypothyroidism. This is a case of a 43-year-old male presenting with short stature and heart failure. The patient was admitted at the medicine ward of the Philippine General Hospital (PGH) for dyspnea. This paper will investigate several issues: differentiating congenital from acquired hypothyroidism, the relationship between hypothyroidism and the cardiomyopathies, and the therapeutic options in patients with cardiomyopathy secondary to hypothyroidism. This is a case of a 43-year-old male presenting with short stature and heart failure. The patient was admitted at the medicine ward of the Philippine General Hospital (PGH) for dyspnea. This paper will investigate several issues: differentiating congenital from acquired hypothyroidism, the relationship between hypothyroidism and the cardiomyopathies, and the therapeutic options in patients with cardiomyopathy secondary to hypothyroidism.
Vault RNA1-1 riboregulates the autophagic function of p62 by binding to K7/R21 that are critical for p62 oligomerisation

30 Cellular processes can be regulated at multiple levels, including transcriptional, post- 31 transcriptional and post-translational mechanisms. We have recently shown that the 32 small, non-coding vault RNA1-1 negatively riboregulates p62 oligomerisation in 33 selective autophagy through direct interaction with the autophagic receptor. This 34 function is highly specific for this Pol III transcript, but the determinants of this 35 specificity and a mechanistic explanation of how vault RNA1-1 inhibits p62 36 oligomerisation are lacking. Here, we combine biochemical and functional 37 experiments to answer these questions. We show that the PB1 domain and adjacent 38 linker region of p62 (aa 1-122) are necessary and sufficient for specific vault RNA1-1 39 binding, and identify lysine 7 and arginine 21 as key hinges for p62 riboregulation. 40 Chemical structure probing of vault RNA1-1 further reveals a central flexible loop 41 within vault RNA1-1 that is required for the specific interaction with p62. Overall, our 42 data provide molecular insight into how a small RNA riboregulates protein-protein 43 interactions critical to the activation of specific autophagy. 44
Hysteresis In Unemployment: Panel Unit Roots Tests Using State Level Data

Most studies that use classical unit-root tests in OECD countries support the unemployment hysteresis hypothesis. However, similar classical tests performed on US data yield mixed results, uncovering specification issues. This study uses a number of panel unit root tests, which are known to overcome specification problems, to check the existence of hysteresis in unemployment data from three Massachusetts regions. The empirical results strongly reject a unit root in the rates, refuting the unemployment hysteresis hypothesis.
T Cells + Resides in a Subpopulation of CD43 Small Intestinal Intraepithelial Lymphocytes Maximum Immunobioactivity of Murine

CD43 has been linked to many function-associated T cell activities. Using mAbs that recognize two different CD43 determinants, we show that, although mouse small intestinal intraepithelial lymphocytes (IELs) expressed the CD43 core molecule reactive with mAb R2/60, only about one-half of the total IELs—including some but not all of the TCR (cid:2)(cid:3) and TCR (cid:4)(cid:5) cells—expressed the CD43 S7 (cid:6) reactive determinant. CD43 S7 (cid:1) IELs secreted more IL-2, IL-4, IL-10, IL-17, and IFN- (cid:4) following anti-CD3 stimulation, and were > 4-fold more cytotoxic in fresh isolates and > 16-fold more cytotoxic after anti-CD3 stimulation, than S7 (cid:6) IELs. S7 (cid:1) but not S7 (cid:6) IELs from the ileum of IL-10 (cid:6) / (cid:6) mice spontaneously produced IFN- (cid:4) . In vivo BrdU uptake by IELs in non-Ag-primed mice was greatest in the S7 (cid:1) population, indicating that signiﬁcantly more S7 (cid:1) IELs than S7 (cid:6) IELs undergo cell expansion under normal homeostatic conditions. DNA microarray analyses showed that S7 (cid:1) IELs expressed higher levels of genes associated with activated T cells, whereas S7 (cid:6) IELs expressed genes used in the regulation of NK cells. These ﬁndings deﬁne two functionally distinct populations of IELs based on CD43 expression independent of TCR class, and they identify a subset of IELs that may serve as a target to better control intestinal
Population-level genomics identifies the emergence and global spread of a human transmissible multidrug-resistant nontuberculous mycobacterium

Lung infections with Mycobacterium abscessus, a species of multidrug resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF) where they accelerate inflammatory lung damage leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.
COPD_A_264944 2411..2419

1Department of Diagnostic and Therapeutical Procedures, General Hospital Našice, Našice 31500, Croatia; 2Faculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek, Osijek 31000, Croatia; 3Department for Biochemical Analysis, General Hospital Našice, Našice 31500, Croatia; 4Department of Internal Medicine, General Hospital Našice, Našice 31500, Croatia Objective: This study evaluates the total antioxidant status (TAS) in plasma of stable chronic obstructive pulmonary disease (COPD) patients. Earlier studies of their relationship showed inconsistent findings. Patients and Methods: We compared TAS between 90 COPD patients and 30 ageand sex-matched controls (mean age 67 ± 7.9, 87 males and 33 females) according to airway obstruction severity, gender, smoking status (current/ former/ non-smoker), smoking-dose, the number of exacerbations in the previous year, nutritional status and hypercapnia. Results: There were no differences in pack-years between COPD and controls, neither in COPD groups. The median time from the last exacerbation was 5 months (interquartile range 3−8.3). TAS was significant higher in COPD than controls (1.68 [1.55−1.80] versus 1.59 [1.54−1.68], respectively; P = 0.03). TAS was significantly higher in COPD men than women (1.7 [1.6−1.8] versus 1.57 [1.5−1.7], respectively; P = 0.001). In COPD groups, there were no significant differences between the severity of airway obstruction and TAS. We found significant positive correlation between pack-years and TAS in all participants (Rho = 0.429, P = 0.004) and COPD patients (Rho = 0.359, P = 0.02), but not in controls. TAS was a significant predictor of COPD (β = 3.26; P = 0.04; OR = 26.01; 95% CI: 1.20 to 570.8). We failed to find significant differences between TAS and smoking status, frequency of exacerbations in the previous year, nutritional status and hypercapnia. Conclusion: TAS was a significant predictor of COPD. TAS was a significantly higher in stable COPD than controls, higher in COPD men than women, but there was no significant correlation between TAS and the airway obstruction severity. Our results suggest that it could be appropriate to include the time from the last exacerbation in the oxidant–antioxidant balance analysis of COPD patients.
Social Foundation of Executive Functions

In this study, we propose that infant social cognition may “bootstrap” the successive development of domain-general cognition in line with the cultural intelligence hypothesis. Using a longitudinal design, 6-month-old infants (N = 118) were assessed on two basic social cognitive tasks targeting the abilities to share attention with others and understanding other peoples’ actions. At 10 months we measured the quality of the child’s social learning environment, indexed by parent’s abilities to provide scaffolding behaviors during a problem-solving task. Eight months later the children were followed-up with a cognitive test-battery, including tasks of inhibitory control and working memory. Our results showed that better infant social cognitive abilities interacted with better parental scaffolding skills in predicting inhibitory control in toddlerhood. This suggest that infants’ who are better at understanding social signals are also better equipped to make the most of existing social learning opportunities, which in turn benefit future cognitive outcomes.
Topoisomerase I Inhibitor Irinotecan New Zealand White Mice Treated with the Prolonged Survival of New Zealand Black × Reversal of Established Lupus Nephritis and

Systemic lupus erythematosus is a chronic autoimmune disorder that predominantly affects women of childbearing age. Lupus-associated glomerulonephritis is a major cause of mortality in these patients. Current treatment protocols for systemic lupus erythematosus include cyclophosphamide, prednisolone, azathioprine, and mycophenolate mofetil. However, in mice none of these agents alone or in combination were shown to reverse established proteinuria. Using New Zealand Black 3 New Zealand White F1 mice, we report that administration of the topoisomerase I inhibitor irinotecan from week 13 completely prevented the onset of proteinuria and prolonged survival up to at least 90 wk without detectable side effects. Furthermore, application of irinotecan to mice with established lupus nephritis, as indicated by grade 3+ ( ‡ 300 mg/dl) and grade 4+ ( ‡ 2000 mg/dl) proteinuria and, according to a median age of 35 wk, resulted in remission rates of 75% and 55%, respectively. Survival was signiﬁcantly prolonged with 73 wk (grade 3+ and 4+ combined) versus 40 wk for control animals. Although total IgG and anti-dsDNA Abs in the serum and mesangial IgG deposits in the kidneys were not reduced in irinotecan-treated mice, subendothelial immune deposits were con-siderably diminished, suggesting a prevention of glomerular basement membrane disruption. This effect was accompanied by increased rates of ssDNA breaks and inhibition of renal cell apoptosis being different to what is known about irinotecan in anticancer therapy. In conclusion, our data provide evidence that irinotecan might represent an entirely new strategy for the treatment of systemic lupus erythematosus. The Journal of Immunology , 2010, 184: 2175–2182.
TRANSPORT AND FATE OF BACTERIA IN POROUS MEDIA BY

26 Introduction 27 Material and Methods 29 -Bacteria, Sand, and Electrolyte Solutions 29 -Electrokinetic Characterization and DLVO Calculations 30 -Batch Experiment 31 -Column Experiment 31 -Fluid Flow around Collectors and Cell Retention 33 Results and Discussion 35 -DLVO Calculations 35 -Batch experiments 36 -Column experiment 37 -Analysis of Resisting and Driving Torques 40 -Immobile Zones and Cell Retention 43 -Coupling of Factors in Cell Retention 45
Patients with Rare Cancers in the Drug Rediscovery Protocol (DRUP) Benefit from Genomics-Guided Treatment

Abstract Purpose: Patients with rare cancers (incidence less than 6 cases per 100,000 persons per year) commonly have less treatment opportunities and are understudied at the level of genomic targets. We hypothesized that patients with rare cancer benefit from approved anticancer drugs outside their label similar to common cancers. Experimental Design: In the Drug Rediscovery Protocol (DRUP), patients with therapy-refractory metastatic cancers harboring an actionable molecular profile are matched to FDA/European Medicines Agency–approved targeted therapy or immunotherapy. Patients are enrolled in parallel cohorts based on the histologic tumor type, molecular profile and study drug. Primary endpoint is clinical benefit (complete response, partial response, stable disease ≥ 16 weeks). Results: Of 1,145 submitted cases, 500 patients, including 164 patients with rare cancers, started one of the 25 available drugs and were evaluable for treatment outcome. The overall clinical benefit rate was 33% in both the rare cancer and nonrare cancer subgroup. Inactivating alterations of CDKN2A and activating BRAF aberrations were overrepresented in patients with rare cancer compared with nonrare cancers, resulting in more matches to CDK4/6 inhibitors (14% vs. 4%; P ≤ 0.001) or BRAF inhibitors (9% vs. 1%; P ≤ 0.001). Patients with rare cancer treated with small-molecule inhibitors targeting BRAF experienced higher rates of clinical benefit (75%) than the nonrare cancer subgroup. Conclusions: Comprehensive molecular testing in patients with rare cancers may identify treatment opportunities and clinical benefit similar to patients with common cancers. Our findings highlight the importance of access to broad molecular diagnostics to ensure equal treatment opportunities for all patients with cancer.
A study on the effect of organizational climate on the commitment and work involvement of employees in the ITES sector

The purpose of the paper is to study the effect of organizational climate on the commitment and work involvement of the employees. The study is based on two objectives which aim to study the effect of work environment on the Job commitment and the effect of work environment on the employee’s work involvement. The study was conducted at Intelenet global services an ITES company situated in Ambattur, Chennai. Data was collected from 241 employees working in the organization with the use of questionnaire method. The study was conducted among senior as well as junior employees. The study used Multivariate Analysis to find whether work environment has an effect on the employee willingness to work, career satisfaction and appetite for new challenges. The study also uses Multivariate Analysis to find whether work environment has an effect on the employee decision making, use of skills and motivation to work. The study would be useful for the companies to understand that a good working environment and working condition creates job commitment and involvement among the employees to perform better and sustain within the organization.
MO2MD: Message-Oriented Middleware for Dynamic Management of IoT Devices

— Middleware are fundamental components for Internet of Things (IoT) solutions. They provide general and specific abstractions through which smart devices and their related applications can be easily interconnected. However, due to the wide variety of software and hardware technologies of IoT solutions, the management of the connected devices is still a challenging task, especially for Cloud-Edge based solutions. In this paper, we take advantage of message-oriented computing and Web technologies to propose a solution for devices management without having to worry about the underlying infrastructures or implementation details. In particular, we describe a Web-based middleware that enables configurability and manageability of connected devices in a dynamic manner at the Cloud level.
Interleukin-10 inhibits pulmonary NF- k B activation and lung injury induced by hepatic ischemia-reperfusion

Interleukin-10 inhibits pulmonary NF- k B activation and lung injury induced by hepatic ischemia-reperfusion. Am. J. Physiol. 277 ( Lung Cell. Mol. Physiol. 21): L919–L923, 1999. —Hepatic ischemia and reperfusion cause local and remote organ injury. This injury culminates from an integrated cascade of proinﬂammatory cytokines, chemokines, and adhesion molecules, many of which are regulated by the transcription factor nuclear factor- k B (NF- k B). The anti-inﬂammatory cytokine interleu-kin-10 (IL-10) has been shown to have inhibitory effects on NF- k B. The objective of the current study was to determine whether IL-10 could suppress pulmonary NF- k B activation and ensuing lung injury induced by hepatic ischemia- reperfusion. C57BL/6 mice underwent partial hepatic ischemia with or without intravenous administration of IL-10. Hepatic ischemia-reperfusion resulted in pulmonary NF- k B activation, increased mRNA expression of tumor necrosis factor- a (TNF- a ), and macrophage inﬂammatory protein-2 (MIP-2), as well as increased pulmonary neutrophil accumu- lation and lung edema. Administration of IL-10 suppressed lung NF- k B activation, reduced TNF- a and MIP-2 mRNA expression, and decreased pulmonary neutrophil recruitment and lung injury. The data suggest that IL-10 protects against hepatic ischemia and reperfusion-induced lung injury by inhibiting lung NF- k B activation and the
A Clustering Based Approach to Detect Copy Number Variations in Genomic Regions

— Copy number variation is a kind of structural alteration in the mammalian DNA Sequence which is caused by insertion, deletion and duplication of large DNA segments. It is associated with many complex neurological diseases such as autism, schizophrenia, Alzheimer as well as cancer. Next generation sequencing technology provides us a new platform for detecting copy number alterations. In our method we have detected copy number variations by using NGS technology. Our method used Smith Waterman algorithm for aligning short reads which are generated from sample. The read count data may be affected by GC content and mappability bias. In order to remove this kind of bias, a statistically efficient method was used as this kind of systematic biases could lead to false detection of the read count. Moreover, K-means clustering technique is applied initially to detect the regions with variations. However, the overlapping clusters and the outlier points cannot be handled by k-means clustering algorithm. To recover from this kind of limitations we have used Fuzzy c-means clustering and observed that it was more efficient in handling genomic breakpoints. In addition our approach has higher sensitivity and F-score value in detecting large sized alterations.
Diagnosis & Exploration of Massively Univariate fMRI Models

The goal of this work is to establish the validity of inferences in fMRI modeling through diagnosis of linear model assumptions, and to characterize fMRI signal and artifacts through exploratory data analysis. While model diagnosis and exploration is an integral part of any statistical modeling endeavor, these aspects have been mostly neglected in functional neuroimaging. We present methods that make diagnosis and exploration of fMRI data feasible. Exploiting the spatiotemporal structure of the data, we use spatial and temporal summaries that characterize model fit and residuals. Our methods involve both statistical and graphical tools. Our statistical tools are diagnostic summary statistics with tractable null distributions, which we have validated in the context of a typical autocorrelated fMRI model. Our dynamic graphical tools allow the exploration of multiple spatial and temporal summaries, with the ability to quickly jump to spatiotemporal detail. We apply our method to a fMRI dataset, demonstrating their ability to localize subtle artifacts and to discover systematic experimental variation not captured by the model.
MICRO ASPECT MINING IN A COLLABORATIVE ENVIRONMENT USING A NOVEL DISCRIMINATIVE INFINITE HIDDEN MARKOV MODEL

Collaborative environments, which enable companywide global teams to identify the source of the problem and develop a response, are an excellent antidote to a lack of preparedness. Knowledge sharing is an activity through which knowledge is exchanged among people, friends, families, communities or organizations. In order to gain knowledge, user may try to acquire similar information on the web in this collaborative environment. The framework formulates tasks from sessions. There is no existing technique for micro aspect mining. A novel discriminative infinite Hidden Markov Model is proposed to mine micro aspects and evolution patterns in each task. The goal is not finding domain experts but a person who has the desired specific knowledge. In this project first summarizing web surfing data into fine grained aspects, and then search over these aspects. This strategy is compared with searching advisors directly over sessions both analytically and empirically
Proceedings of the Annual Meeting of the Cognitive Science Society A Demonstration of The Positive Manifold of Cognitive Test Inter-correlations, and how it Relates to General Intelligence, Modularity, and Lexical Knowledge

Widely recognized in differential psychology, but less so in cognitive science, the positive manifold is the phenomena of all cognitive tests inter-correlating positively. Frequently demonstrated in people, it can also be observed in non-human species. With 217 Ecuadorian adult participants, who performed 11 cognitive tests, we show that all 55 pairwise inter-correlations are positive, and of large magnitude. Additionally, factor analysis revealed a single underlying general, or g factor, often identified as general intelligence. This robustly replicates the positive manifold in a non- WEIRD (Western, Educated, Industrialized, Rich, Democratic) context. We further demonstrate that tests of lexical knowledge, such as word pronunciation, have particularly high loadings on g . We explore explanations for the positive manifold, and the implications for understanding the mind as being composed of independent cognitive processing modules. We propose that the positive manifold reveals a neglected but important role of lexical-conceptual knowledge in high-level, top-down, domain-general cognitive processing.