Miracle-dz/UniFAR-FTUs huggingface dataset:
L’agriculture régénératrice : summum de l’agroécologie ou greenwashing?

Face aux nombreux défis sociétaux à relever (environnement, sécurité alimentaire, santé), différentes formes d’agriculture sont envisagées. Agriculture biologique, agriculture de conservation des sols et maintenant agriculture régénératrice sont trois récits fondateurs se référant à l’agroécologie. Toutefois, l’agriculture régénératrice, nouvelle arrivée en France, reste ambiguë. Nous proposons un cadre d’analyse des formes d’agriculture en termes d’impacts et de services, que nous mobilisons pour comparer l’agriculture régénératrice à celles auxquelles elle se réfère et qui sont bien documentées dans la littérature scientifique. Cette analyse permet d’éclairer des points critiques de l’agriculture régénératrice tels que la question des pesticides et du niveau de séquestration du carbone dans les sols. Ensuite, nous identifions les atouts, faiblesses, opportunités et menaces pour le changement d’échelle de cette agriculture. Nous montrons qu’un atout majeur de l’agriculture régénératrice est de reposer sur un récit mettant en avant un principe, la « régénération » des biens communs (sols, eau, air, biodiversité), qui peut entraîner l’adhésion d’une diversité d’acteurs. Cependant, la mobilisation des acquis de l’agroécologie, en tant que science, pratique et mouvement, pourrait aider à préciser son contenu, encore flou, de façon à ce que ses promesses se traduisent en de réels progrès et ne soient pas exclusivement centrés sur le carbone.
Pegylated Liposomal Doxorubicin, Docetaxel, and Trastuzumab as Neoadjuvant Treatment for HER2-Positive Breast Cancer Patients: A Phase II and Biomarker Study

Background Combined neoadjuvant chemotherapy with trastuzumab and pertuzumab is the standard regimen for human epidermal growth receptor 2 (HER2)-positive breast cancer (BC). However, pertuzumab is not available because it is not on the market or covered by medicare in some regions or poor economy. Anthracyclines and taxanes are cornerstones in BC chemotherapy, and their combination contributes to satisfactory efficiency in neoadjuvant settings. Nonetheless, concomitant administration of trastuzumab and an anthracycline is generally avoided clinically due to cardiotoxicity. Pegylated liposomal doxorubicin (PLD) is less cardiotoxic compared with traditional anthracyclines. Here, we conducted this prospective study to evaluate the efficacy, safety, and potential biomarkers for PLD plus trastuzumab and docetaxel as neoadjuvant treatment in HER2-positive BC. Patients and Methods Patients with stage II or III HER2-positive BC were recruited in this multicenter, open-label, single-arm, phase II study. Eligible patients were given 6 cycles of PLD plus docetaxel and trastuzumab. Primary endpoint was total pathological complete response (tpCR, ypT0/is ypN0). Secondary endpoints were breast pathological complete response (bpCR, ypT0/is), objective response rate (ORR), operation rate, breast-conserving surgery rate, and safety. Metadherin (MTDH), glutaminyl-peptide cyclotransferase (QPCT), topoisomerase II alpha (TOP2A), programmed death ligand 1 (PD-L1), and tumor-infiltrating lymphocytes (TILs) were evaluated in BC tissues pre-neoadjuvant for potential biomarkers. Results Between March 2019 and February 2021, 54 patients were enrolled, 50 were included in the analysis, and 35 (70.0%) completed 6 cycles of neoadjuvant treatment. Forty-nine (98.0%) patients underwent surgery with a breast-conserving rate of 44.0%. The tpCR rate, bpCR rate, and ORR were 48.0% (95% CI, 33.7%–62.6%), 60.0% (95% CI, 45.2%–73.6%), and 84.0% (95% CI, 70.9%–92.8%), respectively. tpCR was associated with MTDH (p = 0.002) and QPCT (p = 0.036) expression but not with TOP2A (p = 0.75), PD-L1 (p = 0.155), or TILs (p = 0.76). Patients with HR-negative status were more likely to achieve bpCR compared with those with HR-positive status (76.2% vs. 48.3%, p = 0.047). Grade ≥3 adverse events occurred in 38.0% of patients. Left ventricular ejection fraction decline by ≥10% was reported in 18.0% of patients, and no patient experienced congestive heart failure. Conclusions PLD plus docetaxel and trastuzumab might be a potential neoadjuvant regimen for HER2-positive BC with a high tpCR rate and manageable tolerability. MTDH and QPCT are potential predictive markers for tpCR.
Exploring Ni-accumulation in serpentinophytic taxa of Brassicaceae from Albania and Greece

Abstract The family Brassicaceae includes the highest proportion of Ni-hyperaccumulating plants in western Eurasia. Though increasingly relevant for scientific research and biotechnological applications, data about metal concentrations in native populations are still incomplete. The Balkan peninsula is a major diversity centre for Ni-hyperaccumulators due to the wide distribution of ultramafic soils across the area. Using Atomic Absorption Spectrophotometry and material from our field collections, we determined Ni concentration in 31 accessions of 22 taxa from nine tribes: Aethionemeae, Alysseae, Arabideae, Cardamineae, Coluteocarpeae, Erysimeae, Hesperideae, Iberideae and Isatideae. Results confirm that Ni-hyperaccumulation ability is phylogenetically restricted to Alysseae and Coluteocarpeae. Highest Ni-concentrations and bioaccumulation factors were found in Bornmuellera, Odontarrhena and Noccaea. Plants of the facultative serpentinophyte O. chalcidica from the type locality displayed shoot Ni levels > 2000 μg g−1 DW despite growing on non-ultramafic soils with low Ni. This resulted in a remarkably high bioaccumulation factor (91.7). High and low shoot Ni concentrations were instead detected in O. muralis accessions from serpentine and non-serpentine sites, respectively. Hyperaccumulation was confirmed in the endemic O. euboea, for which previous reports were contrasting. Shoot Ni concentration was negatively related to soil Ni concentration in non-accumulating taxa, suggesting efficient exclusion mechanisms on Ni-rich soils.
Blood erythrocyte indices in rats under conditions of acetaminophen-induced toxic injury against the background of alimentary protein deficiency

Despite the available information on variations in the erythrocyte chain of homeostasis under the conditions of drug-induced toxic damage, the question of the biochemical characteristics of erythrocytes in the expose of toxic doses of paracetamol on the background of dietary imbalance in protein remains open. 96 white nonlinear rats were used for the study. During the experiment, the animals consumed a semi-synthetic diet AIN-93 in accordance with the recommendations of the American Institute of Nutrition on the principle of paired nutrition, taking into account the amount of dietary protein per kilogram of diet. Modelling of acute toxic lesions was performed by administration to experimental animals of acetaminophen per os at a rate of 1250 mg/kg body weight. We found that toxic damage by acetaminophen is a key factor in reducing the level of total hemoglobin in the blood of animals (40% compared to control) with a simultaneous decrease in its average concentration (18%) and content in a single erythrocyte (35%), indicating the development of hypochromia, which is an indicator of iron deficiency in the body (iron deficiency anaemia). The synergistic effect of nutritional protein deficiency and the exposition of toxic doses of acetaminophen is accompanied by a decrease in total erythrocytes (50% compared to control) due to their increased hemolysis (up to 32% in 0.9% NaCl) with a simultaneous decrease in hematocrit up to 16% and the average volume of erythrocytes (1.4 times compared with the control). At the same time, the established changes in oxyhemoglobin decrease against the background of increased fetal hemoglobin content under the conditions of toxic damage and alimentary protein deficiency may serve as an additional criterion for comprehensive assessment in the diagnosis of anaemic syndrome in inflammatory diseases of different genesis against nutrient-associated conditions. Thus, the study of changes in erythrocyte indices in the development of acetaminophen-induced lesions on the background of nutrients’ alimentary deprivation can increase the effectiveness of monitoring the course of these pathologies and approaches to their correction.
TORCH, Anti-cardiolepin, and Anti-phospholipids in Women with Repeated Miscarriage in Mosul City

Abstract Background and Objective: The present study aimed to identify a connection between common viral infections and women who had repeatedly miscarriages. Material and Methods: This study is a retrospective study which has been carried out on 2010 records in Mosul city/Iraq, and the patients were all women of child-bearing age (20-35 years old). All of the women had suffered from an abortion at least once before. The target viruses in charge for this study include; Toxoplasma gundi, Cytomegalovirus, Rubella virus, and Herpes virus. Results and Conclusion: The analysis is based on the detection of the anti-bodies which confirmed a negative correlation between antibodies level and active viral infection, together with no clear association between the presence of active infectious status and miscarriage. Additionally, only few positive cases for each individual patient were positive for viral infection. Hence, the outcome confirmed no clear association between presence of infectious agent and repeated miscarriage. Nonetheless, rubella and cytomegalovirus have shown the highest contribution in this regard.
Low‐complexity robust adaptive beamforming method for MIMO radar based on covariance matrix estimation and steering vector mismatch correction

In this study, the authors consider a low-complexity robust adaptive beamforming problem in a collocated multiple-input multiple-output (MIMO) radar. This study is motivated by the fact that in practical applications, the conventional adaptive beamforming algorithm for MIMO radar requires a large computational complexity and suffers from a great performance degradation because of the finite number of training snapshots, the desired signal steering vector mismatch and the corruption of training data by the desired signal. Since the dimension of the virtual steering vector of the MIMO radar is relatively large, the proposed method can estimate the covariance matrix by using a low-complexity method to effectively improve the computational efficiency of the adaptive beamforming algorithm and the robustness of the beamformer against the covariance matrix uncertainty. Besides, based on the estimated covariance matrix, the proposed method can also correct the desired signal steering vector mismatch to efficiently prevent the desired signal cancellation phenomenon. Simulation results demonstrate that the performance of the proposed method is always close to that of the optimal processing in a wide range of signal-to-noise ratio or of the number of training snapshots.
Comparable Analysis on Frequency Selective Surface (FSS) Structures using Finite FDTD in FORTRAN and CST

In this work, two dissimilar forms of frequency selective surface (FSS) shaped are consider designing in Computer Simulation Technology (CST) and FORTRAN simulator. Square loop FSS is the first design and followed by the cross dipole FSS. The works start using Genetic Algorithm (GA) as the optimization tool to generate bits of the chromosome in designing the shape of energy-saving glass (ESG). Then, another way is using the Finite Difference Time Domain (FDTD) was working as a design the complicated shape in pixelized shape based on the unit cell thought. For the result, it can compare on several performance parameters. Firstly, in CST, the results of S21 shown - 43.2 dB as resonant frequency is at 12.8 GHz. For FORTRAN simulator, it shows the performance of - 68.1 dB at 12.8 GHz of resonant frequency.
Breakdown Field Model for 3C-SiC Power Device Simulations

Modeling and simulation of 3C-SiC power devices such as MOSFETs and diodes requires a model for the breakdown field that is consistent with the Monte-Carlo-simulated ionization rates of electron and holes and supported by experimental results. The challenge one faces is the limited number of publications reporting such calculations and the limited availability of high-quality ionization breakdown data for 3C-SiC diodes. We therefore performed a series of 2D simulations of both n-type and p-type Schottky diodes and p+-n diodes that confirms the general breakdown field trend with doping density obtained from experiments. We uncovered a difference between n-type and p-type diode breakdown behavior, identified the discrepancy between the calculations and the experimental data, and extracted a simple breakdown field model, useful for further 3C-SiC device design and simulation.
Loss of Eicosapentaenoic Acid (EPA) after Retort Sterilization of the EPA-BCAA Fortified Complete Nutrition Drink

Retort sterilization is cost-effective for small-scale production of specialized nutrition products. However, the sensory properties and stability of active ingredients after sterilization remain undetermined. This study aimed to investigate the effect of retort on the existence of functional compounds and the sensory satisfaction of a fortified complete nutrition formula with branched-chain amino acids (BCAAs), and fish oil providing eicosapentaenoic acid (EPA). Changes in EPA and BCAA contents after retort were determined by using LC-MS/MS. Nutrient values, osmolality, rheology and sensory acceptance of the processed fortified and control formulas were compared. After retort, the fortified formula had an increase in all types of BCAAs but 30% loss of EPA (p = 0.001). The fortified formula had slightly higher protein and fiber contents, along with increased osmolality. It had higher viscosity and shear stress, but similar IDDSI level at 0. Among flavors tested, the fortified formula with Japanese rice flavor received the highest satisfaction scores with over 80% sensory acceptance. In conclusion, retort sterilization preserved BCAAs of the functional drink, but the addition of 30% fish oil was required to compensate for the EPA loss. The sterilized fortified formula with Japanese rice flavor was sensory acceptable.
An Active EMI Cancellation Technique Achieving a 25-dB Reduction in Conducted EMI of LIN Drivers

Robustness to electromagnetic interference (EMI) is one of the primary design aspects of state of the art automotive ICs like System Basis Chips (SBCs) which provide a wide range of analog, power regulation and digital functions on the same die. One of the primary sources of conducted EMI on the Local Interconnect Network (LIN) driver output is an integrated switching DC-DC regulator noise coupling through the parasitic substrate capacitance of the SBC. In this paper an adaptive active EMI cancellation technique to cancel the switching noise of the DC-DC regulator on the LIN driver output to ensure electromagnetic compatibility (EMC) is presented. The proposed active EMI cancellation circuit synthesizes a phase synchronized cancellation pulse which is then injected onto the LIN driver output using an on-chip tunable capacitor array to cancel the switching noise injected via substrate. The proposed EMI reduction technique can track and cancel substrate noise independent of process technology and device parasitics, input voltage, duty cycle and loading conditions of the DC-DC switching regulator. The EMI cancellation system is designed and fabricated on a 180nm Bipolar-CMOS-DMOS (BCD) process with an integrated power stage of a DC-DC buck regulator at a switching frequency of 2MHz along with an automotive LIN driver. The EMI cancellation circuit occupies an area of 0.7 mm2, which is less than 3% of the overall area in a standard SBC and consumes 12.5 mW of power and achieves 25 dB reduction of conducted EMI in the LIN driver output’s power spectrum at the switching frequency and its harmonics.
Neural Network System for Diagnosing Liver Failure in Surgery

Clinical decision support systems are rapidly developing along with digital technologies nowadays. Neural network methods have become more common in solving practical problems in healthcare. Today, clinical decision support systems are significant medical tools. The authors have developed a neural network system to diagnose liver failure. The "Neurodiagnost" system was tested in 270 patients with liver failure due to viral hepatitis B or C. As a result, clinical testing of the "Neurodiagnost" system demonstrated coincidence of neural network and laboratory diagnostics with a probability equal 91.5 % (247 patients). The use of the "Neurodiagnost" program can help reduce the risk of developing liver failure in surgery.
Akta Agrosia Use of Rhizobacteria as an Antagonistic Agent at Various Formulations to Control Sheath Rot Disease ( Sarocladium oryzae ) on Rice Crops

The objective of this reserach were to determine the potency of antagonistic rhizobacteria and to find the best formulations of isolate to control sheat root disease ( Sarocladium oryzae ). The research was carried out from July to December 2019 in the Plant and Disease Laboratory and the Greean House of the Faculty of Agriculture Jember University. The experiment was conducted using a completely randomized design (CRD) 2 factors, namely isolates and formulation. The first factor was Rhizobacteria isolates, consisting of 4 factors levels; control, Bacillus sp. isolate, Pseudomonas fluorescens isolate, and Bacillu s sp. + Pseudomonas fluorescens isolate. The second factor ws formulation isolates, consisting of 4 levels; glucose 10% + potato water 70% + bacterial starter 20%, Fructose 20% + coconut water 60% + bacteria; starter 20%, glucose 10% + CMC 2% + monmorilonite 68% + bacterial starter 20%, fructose 20% + CMC 2% + kaolin 58% + bacterial starter 20%. The result showed that the treatment of Bacillus sp. with formulation glucose 10% + CMC 2% + monmorilonite 68% + bacterial starter 20%, showed the best result, with a control effectiveness of 78.31%.
A Comprehensive VSM Control Strategy Designed for Unbalanced Grids

A virtual synchronous machine (VSM) is a converter which, compared to other types of converters, has more friendly interactions with the power grid because it is able to simulate the external characteristics of a synchronous machine, which can provide virtual inertia and damping. When the grid voltage is unbalanced, there will be negative sequence current and power oscillations. There will also be double-frequency ripples on the DC bus, which affect the normal operation of the DC power source or load. In order to solve these problems, a comprehensive control strategy is proposed in this paper. The principle of a VSM operated as a current source converter, also called VISMA, is used in the design. A complex coefficient filter is applied to separate the positive and negative sequence components of the grid voltage. By analyzing the reasons of power oscillations under unbalanced voltage, the electrical simulation part of the VSM is improved to achieve several objectives: to suppress negative sequence current and DC voltage ripples. Additionally, the rated voltage in the reactive control part is adaptively adjusted to stabilize the system. The validity of the proposed control strategy is verified by simulation and experiment.
Venous Thromboembolism in Sepsis: From Bench to Bedside

Septic patients were commonly affected by coagulation disorders; thus, they are at high risk of thrombotic complications. In the last decades, novel knowledge has emerged about the interconnected and reciprocal influence of immune and coagulation systems. This phenomenon is called immunothrombosis, and it indicates an effective response whereby immune cells and the coagulation cascade cooperate to limit pathogen invasion and endothelial damage. When this network becomes dysregulated due to a systemic inflammatory activation, as occurs during sepsis, it can result in pathological thrombosis. Endothelium, platelets and neutrophils are the main characters involved in this process, together with the TF and coagulation cascade, playing a critical role in both the host defense and in thrombogenesis. A deeper understanding of this relationship may allow us to answer the growing need for clinical instruments to establish the thrombotic risk and treatments that consider more the connection between coagulation and inflammation. Heparin remains the principal therapeutical response to this phenomenon, although not sufficiently effective. To date, no other significant alternatives have been found yet. In this review, we discuss the role of sepsis-related inflammation in the development and resolution of venous thromboembolism and its clinical implications, from bench to bedside.
Análisis de Algoritmos para Detección de Pedaleo en Interfaces Cerebro-Máquina

El uso de interfaces cerebro-máquina en personas que han sufrido un accidente cerebro-vascular puede ayudar en su proceso de rehabilitación mediante la implicación cognitiva del paciente. Dichas interfaces traducen las ondas cerebrales en comandos con el fin de controlar un dispositivo mecánico de movimiento asistido. No obstante, el control de estos dispositivos debería ser más robusto y tener una alta precisión. Este trabajo estudia si algoritmos basados en transformadas como las de Stockwell o Hilbert-Huang pueden mejorar el control de estos dispositivos aumentando su precisión, y si es recomendable llevar a cabo una personalización por sujeto y configuración de electrodos. Mediante el análisis de cinco voluntarios se comprueba además, que no es posible detectar con suficiente robustez la intención motora a partir de la desincronización/sincronización relacionada a eventos motores con únicamente los datos previos al movimiento. Por ello, es preciso extender el tiempo de análisis a los dos segundos posteriores al inicio del movimiento.
Antioxidant Activity of New Sulphur- and Selenium-Containing Analogues of Potassium Phenosan against H2O2-Induced Cytotoxicity in Tumour Cells

Among known phenolic antioxidants, the overwhelming majority of compounds have lipophilic properties and the number of known water-soluble compounds is very small. The list of hydrophilic phenolic antioxidants can be expanded via the synthesis of a structurally related series of polyfunctional compounds for further research on their biological activity in vitro. New sulphur- and selenium-containing analogues of antioxidant potassium phenosan were synthesised. In vitro cytotoxicity and cytostaticity as well as antioxidant activity against H2O2-induced cytotoxicity to human cell lines (HepG2, Hep-2 and MCF-7) were investigated by high-content analysis. A selenium-containing analogue showed higher biological activity than did a sulphur-containing one. As compared to the activity of potassium phenosan, the selenium-containing analogue had a cell line-dependent antioxidant effect against H2O2-induced cytotoxicity: comparable in HepG2 cells and greater in Hep-2 cells. The selenium-containing analogue significantly increased the death of MCF-7 cells at concentrations above 50 µM. The sulphur-containing analogue has lower biological activity as compared to potassium phenosan and the selenium-containing analogue.