Miracle-dz/UniFAR-FTUs huggingface dataset:
Microtubules as Major Regulators of Endothelial Function: Implication for Lung Injury

Endothelial dysfunction has been attributed as one of the major complications in COVID-19 patients, a global pandemic that has already caused over 4 million deaths worldwide. The dysfunction of endothelial barrier is characterized by an increase in endothelial permeability and inflammatory responses, and has even broader implications in the pathogenesis of acute respiratory syndromes such as ARDS, sepsis and chronic illnesses represented by pulmonary arterial hypertension and interstitial lung disease. The structural integrity of endothelial barrier is maintained by cytoskeleton elements, cell-substrate focal adhesion and adhesive cell junctions. Agonist-mediated changes in endothelial permeability are directly associated with reorganization of actomyosin cytoskeleton leading to cell contraction and opening of intercellular gaps or enhancement of cortical actin cytoskeleton associated with strengthening of endothelial barrier. The role of actin cytoskeleton remodeling in endothelial barrier regulation has taken the central stage, but the impact of microtubules in this process remains less explored and under-appreciated. This review will summarize the current knowledge on the crosstalk between microtubules dynamics and actin cytoskeleton remodeling, describe the signaling mechanisms mediating this crosstalk, discuss epigenetic regulation of microtubules stability and its nexus with endothelial barrier maintenance, and overview a role of microtubules in targeted delivery of signaling molecules regulating endothelial permeability and inflammation.
Identification of Micro Ribonucleic Acids and Their Targets in Response to Plasmodiophora brassicae Infection in Brassica napus

Clubroot disease, which is caused by the soil-borne pathogen Plasmodiophora brassicae War (P. brassicae), is one of the oldest and most destructive diseases of Brassica and cruciferous crops in the world. Plant microRNAs [micro ribonucleic acids (miRNAs)] play important regulatory roles in several developmental processes. Although the role of plant miRNAs in plant-microbe interaction has been extensively studied, there are only few reports on the specific functions of miRNAs in response to P. brassicae. This study investigated the roles of miRNAs and their targets during P. brassicae infection in a pair of Brassica napus near-isogenic lines (NILs), namely clubroot-resistant line 409R and clubroot-susceptible line 409S. Small RNA sequencing (sRNA-seq) and degradome-seq were performed on root samples of 409R and 409S with or without P. brassicae inoculation. sRNA-seq identified a total of 48 conserved and 72 novel miRNAs, among which 18 had a significant differential expression in the root of 409R, while only one miRNA was differentially expressed in the root of 409S after P. brassicae inoculation. The degradome-seq analysis identified 938 miRNA target transcripts, which are transcription factors, enzymes, and proteins involved in multiple biological processes and most significantly enriched in the plant hormone signal transduction pathway. Between 409R and 409S, we found eight different degradation pathways in response to P. brassicae infection, such as those related to fatty acids. By combining published transcriptome data, we identified a total of six antagonistic miRNA-target pairs in 409R that are responsive to P. brassicae infection and involved in pathways associated with root development, hypersensitive cell death, and chloroplast metabolic synthesis. Our results reveal that P. brassicae infection leads to great changes in miRNA pool and target transcripts. More interestingly, these changes are different between 409R and 409S. Clarification of the crosstalk between miRNAs and their targets may shed new light on the possible mechanisms underlying the pathogen resistance against P. brassicae.
Long-Term Release of Dexamethasone With a Polycaprolactone-Coated Electrode Alleviates Fibrosis in Cochlear Implantation

Cochlear implantation (CI) is the major treatment for severe sensorineural hearing loss. However, the fibrotic tissue forming around the electrodes reduces the treatment effectiveness of CI. Dexamethasone (DEX) is usually applied routinely in perioperative treatment of cochlear implantation (CI), but its diffusion in the inner ear after systemic administration is limited. In the present study, an electrode coated with polycaprolactone (PCL) loaded with dexamethasone was developed with a simple preparation process to maintain the stability of the electrode itself. The DEX-loaded PCL coating has good biocompatibility and does not change the smoothness, flexibility, or compliance of the implant electrode. Stable and effective DEX concentrations were maintained for more than 9 months. Compared with the pristine electrode, decreasing intracochlear fibrosis, protection of hair cells and spiral ganglion cells, and better residual hearing were observed 5 weeks after PCL-DEX electrode implantation. The PCL-DEX electrode has great potential in preventing hearing loss and fibrosis by regulating macrophages and inhibiting the expression of the fibrosis-related factors IL-1β, TNF-α, IL-4, and TGF-β1. In conclusion, the PCL-DEX electrode coating shows promising application in CI surgery.
Innate Immunity in the Middle Ear Mucosa

Otitis media (OM) encompasses a spectrum of clinical presentations ranging from the readily identifiable Acute OM (AOM), which is characterised by otalgia and fever, to chronic otitis media with effusion (COME) where impaired hearing due to middle ear effusion may be the only clinical symptom. Chronic suppurative OM (CSOM) presents as a more severe form of OM, involving perforation of the tympanic membrane. The pathogenesis of OM in these varied clinical presentations is unclear but activation of the innate inflammatory responses to viral and/or bacterial infection of the upper respiratory tract performs an integral role. This localised inflammatory response can persist even after pathogens are cleared from the middle ear, eustachian tubes and, in the case of respiratory viruses, even the nasal compartment. Children prone to OM may experience an over exuberant inflammatory response that underlies the development of chronic forms of OM and their sequelae, including hearing impairment. Treatments for chronic effusive forms of OM are limited, with current therapeutic guidelines recommending a “watch and wait” strategy rather than active treatment with antibiotics, corticosteroids or other anti-inflammatory drugs. Overall, there is a clear need for more targeted and effective treatments that either prevent or reduce the hyper-inflammatory response associated with chronic forms of OM. Improved treatment options rely upon an in-depth understanding of OM pathogenesis, particularly the role of the host innate immune response during acute OM. In this paper, we review the current literature regarding the innate immune response within the middle ear to bacterial and viral otopathogens alone, and as co-infections. This is an important consideration, as the role of respiratory viruses as primary pathogens in OM is not yet fully understood. Furthermore, increased reporting from PCR-based diagnostics, indicates that viral/bacterial co-infections in the middle ear are more common than bacterial infections alone. Increasingly, the mechanisms by which viral/bacterial co-infections may drive or maintain complex innate immune responses and inflammation during OM as a chronic response require investigation. Improved understanding of the pathogenesis of chronic OM, including host innate immune response within the middle ear is vital for development of improved diagnostic and treatment options for our children.
COVID-19 Crisis Management: Lessons From the United Arab Emirates Leaders

This study analyses the UAE leadership's approach in response to the COVID-19 crisis through the Organization for Economic Co-operation and Development's Strategic Crisis Management Framework. This framework analyzes the crisis management in three phases: the preparedness, the response to mitigate damage and the feedback mechanism after the crisis. The analysis showed that the key components of the UAE's crisis management included efficient and able governance, integrated utilization of public-private partnerships and a global workforce of excellence. As a result, the UAE now ranks among the top 10 countries worldwide for its leadership and proactive approach during the COVID-19 pandemic, according to Global Response to Infectious Diseases Index. The SWOT analysis on the response toward COVID-19 crisis management helped in critically analyzing and understanding the UAE's unified and systematic response to the pandemic, which provides developing and developed countries alike a new high standard for leadership and effective public health management.
Bioinformatic Teaching Resources – For Educators, by Educators – Using KBase, a Free, User-Friendly, Open Source Platform

Over the past year, biology educators and staff at the U.S. Department of Energy Systems Biology Knowledgebase (KBase) initiated a collaborative effort to develop a curriculum for bioinformatics education. KBase is a free web-based platform where anyone can conduct sophisticated and reproducible bioinformatic analyses via a graphical user interface. Here, we demonstrate the utility of KBase as a platform for bioinformatics education, and present a set of modular, adaptable, and customizable instructional units for teaching concepts in Genomics, Metagenomics, Pangenomics, and Phylogenetics. Each module contains teaching resources, publicly available data, analysis tools, and Markdown capability, enabling instructors to modify the lesson as appropriate for their specific course. We present initial student survey data on the effectiveness of using KBase for teaching bioinformatic concepts, provide an example case study, and detail the utility of the platform from an instructor’s perspective. Even as in-person teaching returns, KBase will continue to work with instructors, supporting the development of new active learning curriculum modules. For anyone utilizing the platform, the growing KBase Educators Organization provides an educators network, accompanied by community-sourced guidelines, instructional templates, and peer support, for instructors wishing to use KBase within a classroom at any educational level–whether virtual or in-person.
QF-TraderNet: Intraday Trading via Deep Reinforcement With Quantum Price Levels Based Profit-And-Loss Control

Reinforcement Learning (RL) based machine trading attracts a rich profusion of interest. However, in the existing research, RL in the day-trade task suffers from the noisy financial movement in the short time scale, difficulty in order settlement, and expensive action search in a continuous-value space. This paper introduced an end-to-end RL intraday trading agent, namely QF-TraderNet, based on the quantum finance theory (QFT) and deep reinforcement learning. We proposed a novel design for the intraday RL trader’s action space, inspired by the Quantum Price Levels (QPLs). Our action space design also brings the model a learnable profit-and-loss control strategy. QF-TraderNet composes two neural networks: 1) A long short term memory networks for the feature learning of financial time series; 2) a policy generator network (PGN) for generating the distribution of actions. The profitability and robustness of QF-TraderNet have been verified in multi-type financial datasets, including FOREX, metals, crude oil, and financial indices. The experimental results demonstrate that QF-TraderNet outperforms other baselines in terms of cumulative price returns and Sharpe Ratio, and the robustness in the acceidential market shift.
Comparison of Primary and Secondary Prophylaxis Using PEGylated Recombinant Human Granulocyte–Stimulating Factor as a Cost-Effective Measure in Malignant Neoplasms: A Multicenter Retrospective Study

Purpose: The aim of the study was to evaluate the cost-effectiveness of PEGylated recombinant human granulocyte–stimulating factor (PEG-rhG-CSF) as a means of achieving primary and secondary prophylaxis against chemotherapy-induced neutropenia cancer cases. Methods: Individuals who underwent PEG-rhG-CSF therapeutics were monitored for 12 months, together with thorough examination of individual medical records for extracting medical care costs. Both prophylaxis-based therapeutic options (primary/secondary) were scrutinized for cost-effectiveness, using a decision-making analysis model which derived the perspective of Chinese payers. One-way and probabilistic sensitivity analyses were used to assess the robustness of the model. Results: In summary, 130 clinical cases treated using PEG-rhG-CSF prophylaxis were included in this study: 51 within the primary prophylaxis (PP) group and 79 within the secondary prophylaxis (SP) group. Compared with SP, PP-based PEG-rhG-CSF successfully contributed to a 14.3% reduction in febrile neutropenia. In general, PP was estimated to reduce costs by $4,701.81 in comparison to SP, with a gain of 0.02 quality-adjusted life years (QALYs). Equivalent results were found in differing febrile neutropenia (FN) risk subgroups. Sensitivity analyses found the model outputs to be most affected for the average time of hospitalization and for the cost of FN. Conclusion: From the perspective of Chinese payers, PP with PEG-rhG-CSF should be considered cost-effective compared to SP strategies in patients who received chemotherapy regimens with a middle- to high-risk of FN.
Clinical Features and Risk Factors for Active Tuberculosis in Takayasu Arteritis: A Single-Center Case-Control Study

Backgrounds Takayasu arteritis (TAK) is a chronic, granulomatous vasculitis correlated with tuberculosis (TB). The two diseases share similar pathological characteristics and clinical manifestations which increase the difficulty to diagnose. Active tuberculosis (ATB) has implications for treatment strategies in TAK patients. Therefore, the investigation of clinical features and potential risk factors of ATB in TAK patients is vital. Methods The study reviewed hospitalized patients diagnosed with TAK in our hospital from 2008, to 2021. TAK patients with ATB were enrolled as the case group. The control group was randomly selected in a 3:1 ratio. The clinical characteristics of TAK patients with and without ATB were compared. Multivariate logistic regression analysis was performed to determine risk factors for ATB in TAK patients. Results We reviewed 1,789 patients and ultimately identified 30 (1.7%) ATB cases. TAK patients with ATB were more prone to develop symptoms including fever (p=0.001), fatigue (p=0.003), cough (p=0.037), expectoration (p<0.001), weight loss (p=0.003), and night sweating (p<0.001). Increased level of hypersensitive C reactive protein (hsCRP, p=0.001), decreased level of albumin (p=0.031), and higher positive rate of T-SPOT.TB test (p<0.001) were observed in the case group. Multivariate logistic regression analysis revealed that hsCRP >8 mg/L (OR 9.108; 95% CI, 1.096–75.711; p=0.041) and positive T-SPOT.TB result (OR 68.669; 95% CI, 7.291–646.738; p<0.001) were risk factors for ATB in TAK patients. The proportion of patients undergoing subsequent surgery for Takayasu arteritis was lower in patients with ATB (p<0.001). Conclusion Our study suggested that the diagnosis of ATB should be considered when TAK patients experienced symptoms including fever, fatigue, weight loss, etc. hsCRP >8 mg/L and positive T-SPOT.TB result were identified as independent risk factors for ATB in TAK patients.
A C0 interior penalty method for mth-Laplace equation

Abstract. In this paper, we propose a C 0 interior penalty method for m th-Laplace equation on bounded Lipschitz polyhedral domain in R d , where m and d can be any positive integers. The standard H 1 -conforming piecewise r -th order polynomial space is used to approximate the exact solution u , where r can be any integer greater than or equal to m . Unlike the interior penalty method in [T. Gudi and M. Neilan, An interior penalty method for a sixth-order elliptic equation , IMA J. Numer. Anal. , 31(4) (2011), pp. 1734–1753], we avoid computing D m of numerical solution on each element and high order normal derivatives of numerical solution along mesh interfaces. Therefore our method can be easily implemented. After proving discrete H m -norm bounded by the natural energy semi-norm associated with our method, we manage to obtain stability and optimal convergence with respect to discrete H m -norm. Numerical experiments validate our theoretical estimate.
Damping analysis of sub-synchronous resonance (SSR) in a wind farm based on DFIG in a series compensated network

The effect of wind generator on sub-synchronous resonance (SSR) is being interested by increasing penetration of wind turbine in power systems,. Purpose of this article is to analyze SSR in a wind farm based on doubly fed induction generator (DFIG) which is connected to compensating series grid. A dynamic model for analysis of induction generator effect and Torsional Interaction (TI) has been utilized and simulated. The IEEE first benchmark model, is modified to include a 100 MW DFIG-based wind farm, is employed as a case study. three phenomena including a) series compensation level, b) the rotor speed, and c) effect of internal parameters of RSC controller on SSR are evaluated and the simulation results are analyzed.
Hybridization of CsPbBr3
 Perovskite Nanocrystals with Polymer Nanofiber to Improve their Luminescence Stability

All-inorganic cesium lead halide perovskite nanocrystals (IPNCs) exhibit exceptional optical properties but the low chemical and structural stability has restricted their long-term applications. According to previous studies, hybridization of IPNCs with other matrix materials provides an efficient method for improving their optical stability. Here, we develop a new strategy to synthesize a chemically and structurally stable CsPbBr3 perovskite material using polymer nanofiber as the protective layer. It is found that CsPbBr3 nanocrystals grow spontaneously inside the polymer nanofiber. Furthermore, the crystal structure and grain size remain substantially unchanged for two months due to the presence of the polymer layer, resulting in a decrease in luminescence quenching. We expect that the results obtained in this work could open new possibilities for the design and development of air-stable CsPbBr3 by hybridization with polymer nanofibers.
False positive FDGuptake inmelanoma patients treatedwith

Department of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands Department of Surgical Oncology, Netherlands Cancer Institute – Antoni van Leeuwenhoek, Amsterdam, The Netherlands Department of Surgical Oncology, University Medical Center Groningen, Groningen, The Netherlands Department of Pathology, Erasmus MC, Rotterdam, The Netherlands Department of Radiology & Nuclear Medicine, Erasmus MC Cancer Institute, Rotterdam, The Netherlands
S0021859621000381jra 206..215

Soil acidity and poor nutrient use efficiency are major limiting factors as regards output potential on heavy soils, soils which are dominated by high proportions of clay and organic matter, with impeded drainage, high buffering capacity and located in high rainfall areas. Lime is applied in order to counteract these limiting factors and in turn improve agricultural output and productivity. The current study investigates the effects of two commonly used lime products at three comparable treatment rates, ground lime (7.5, 5 and 2.5 tonne/ha) and granulated lime (7.5, 2.5 and 1.5 tonne/ha), applied across three distinct sites. The ability of each lime product and treatment rate to counteract soil acidity, increase nutrient availability and influence soil physical structure was assessed over time. On average across sites, 1 tonne/ha of each lime product increased soil pH by 0.15 and 0.21 pH units between ground and granulated lime, respectively. Site 3 experienced the greatest increase change in soil pH in comparison to the other two sites, largely due to lower clay content and cation exchange capacity. Granulated lime was 5.7 times more expensive than ground lime in its ability to reduce soil acidity. The high treatment rate showed the greatest reduction in soil acidity, aluminium and iron concentration as a mean across all sites. Morgan’s soil test phosphorus concentration increased across all sites, with treatment rates having no effect on the rate of increase. There was evidence of reduced soil compaction and lime application showed no negative implication on soil physical structure.
Non-randomness of S-unit lattices

Spherical models of lattices are standard tools in the study of lattice-based cryptography, except for variations in terminology and minor details. Spherical models are used to predict the lengths of short vectors in lattices and the effectiveness of reduction modulo those short vectors. These predictions are consistent with an asymptotic theorem by Gauss, theorems on short vectors in almost all lattices from the invariant distribution, and a variety of experiments in the literature. S-unit attacks are a rapidly developing line of attacks against structured lattice problems. These include the quantum polynomial-time attacks that broke the cyclotomic case of Gentry’s original STOC 2009 FHE system under minor assumptions, and newer attacks that have broken through various barriers previously claimed for this line of work. S-unit attacks take advantage of auxiliary lattices, standard numbertheoretic lattices called S-unit lattices. Spherical models have recently been applied to these auxiliary lattices to deduce core limits on the power of S-unit attacks. This paper shows that these models underestimate the power of S-unit attacks: S-unit lattices, like the lattice Z, have much shorter vectors and reduce much more effectively than predicted by these models. The attacker can freely choose S to make the gap as large as desired, breaking through the core limits previously asserted for S-unit attacks.
Legume-Grass Pastures Enhanced the Growth of Yearling Kiko Does

Legumes can be beneficial in increasing pasture productivity and goat performance. This study’s objective was to evaluate the impact of legume-grass pastures on goat performance. A 50:50 mixture of hairy vetch (Vicia villosa Roth) and Marshall ryegrass (Lolium L.) or hairy vetch and rye (Secale L.) was sown on 50% of the research area and 50% with Marshall ryegrass or rye. Forage samples were collected and processed for dry matter. Yearling Kiko does (19) were divided into two groups: legume-grass mix (10 does) and grass only (9 does), both rotationally stocked in their respective plots. Animal live weight, FAMACHA score, and body condition score were collected at the beginning, fortnightly, and at the end of the study. The goat group on legume-grass pasture gained more weight (67 ± 0.9 lb.) than the group on the grass pasture (65 ± 0.9 lb.) (p<0.05). Results indicated that legume-grass pastures promote the performance of growing does compared to sole-grass pastures.