TECHNISCHE UNIVERSITÄT MÜNCHEN Lehrstuhl für Chemie der Biopolymere Optimization of Oncolytic Viral Therapy for Hepatocellular Carcinoma

s and Presentations: Hofmann, S. , Dong, H. , Cai, W. , Li, Z. , Altomonte, J., Fischer, E. , and Vlassara, H. Restricted intake of glycoxidants leads to elevated serum HDL-C levels in db/db (+/+) mice. Poster presentation at ADA 62 Annual Scientific Sessions. San Francisco, CA 2002. Dong, H. , Altomonte, J., Richter, A. , Meseck, M. , and Woo, S. Suppression of hepatic gluconeogenesis by liver-targeted gene transfer. Poster presentation at ADA 62 Annual Scientific Sessions. San Francisco, CA. 2002. Altomonte, J., Harbaran, S. , Richter, A. , Meseck, M. , and Dong, H. Foxo1 (FKHR) functionally mediates insulin action in regulating hepatic Apolipoprotein C-III Production. Oral presentation at ADA 63rd Annual Scientific Sessions. New Orleans, LA. 2003. Richter, A. , Altomonte, J., Harbaran, S. , Meseck, M. , Accili, D. , and Dong, H. Suppression of hepatic Foxo1 (FKHR) expression improves insulin sensitivity in db/db mice. Oral presentation at ADA 63rd Annual Scientific Sessions. New Orleans, LA. 2003. Altomonte, J., Harbaran, S. , Richter, A. , and Dong, H. Differential production of adiponectin in visceral vs. subcutaneous fat in relation to the pathogenesis of insulin resistance in Zucker fatty rats. Poster presentation at ADA 63 Annual Scientific Sessions. New Orleans, LA. 2003 Zhang, N. , Richter, A. , Suriawinata, J., Altomonte, J., Meseck, M. , and Dong, H. Elevated VEGF production in islet cells enhances islet graft vascularization and improves functional islet mass post transplantation. Oral presentation at ADA 63rd Annual Scientific Sessions. New Orleans, LA. 2003. Altomonte, J., Anthony, K. , Baliga, S. , Xu, J., and Dong, H. Foxo1 plays a role in mediating the effect of fibrates on diabetic dyslipidemia. Poster presentation at ADA 64 Annual Scientific Sessions. Orlando, FL. 2004. Zhang, N. , Richter, A. , Harbaran, S. , Altomonte, J., Zhang, H. , et al. Intra-graft production of VEGF is associated with enhanced islet neovascularization and improved outcome of marginal islet transplantation in diabetic mice. Poster presentation in ADA 64 Annual Scientific Sessions. Orlando, FL. 2004. Altomonte, J., Qu, S. , and Dong, H. Aberrant Foxo1 expression is associated with intrahepatic fat deposition and impaired insulin action in liver. Poster presentation at ADA 65 Annual Scientific Sessions. San Diego, CA. 2005. Qu, S. , Altomonte, J., and Dong, H. Insulin gene therapy corrects hypertriglyceridemia in diabetic mice. Poster presentation at ADA 65 Annual Scientific Sessions. San Diego, CA. 2005. Altomonte, J., Qu, S. , and Dong, H. Fibrates down-regulate Foxo1 expression and ameliorate hypertriglyceridemia in high fructose diet-fed hamsters. Oral presentation in ADA 65 Annual Scientific Sessions. San Diego, CA. 2005. Qu, S. , Altomonte, J., He, J., Meseck, M. , and Dong, H. Aberrant Foxo1 expression in liver associated with intrahepatic fat infiltration and hepatic insulin resistance. Accepted for presentation at 2006 Keystone Symposia: Diabetes Melitus and the Control of Cellular Energy Metabolism. Qu, S. ,, Altomonte, J., He, J., Su, D. , Perdomo, G. , Baliga, S. , and Dong, H. Fibrates downregulate Foxo1 and PGC-1B expression and ameliorate hypertriglyceridemia in high fructose diet-fed hamsters. Accepted for presentation at 2006 Keystone Symposia: Diabetes Melitus and the Control of Cellular Energy Metabolism. Qu, S. , Altomonte, J., Su, D. , and Dong, H. ApoA-V counteracts ApoC-III in improving triglyceride metabolism in hypertriglyceridemic APOC3 transgenic mice. Accepted for presentation at 2006 Keystone Symposia: Diabetes Melitus and the Control of Cellular Energy Metabolism. Marozin, S. , Altomonte, J., Stadtler, F. , Thasler, W. , Schmid, R. , and Ebert, O. Inhibition of the IFN-beta response to dsRNA and VSV infection in hepatocellular carcinoma by alternative spliced isoform interferon regulatory factor 3. Poster presentation at German Society of Gene Therapy (DG-GT) 14 Annual Meeting. Altomonte, J., Braren, R. , Rummeny, E.J., Schmid, R.M. , and Ebert, O. Enhancement of transarterial oncolytic VSV therapy by transient reduction of intratumoral blood flow with degradable starch microspheres in multifocal HCCbearing rats. Poster presentation at In Vivo Barriers to Gene Delivery, 2007, Cold Spring Harbor. Altomonte, J., Marozin, S. , Schmid, R.M. , and Ebert, O. Engineered Newcastle Disease Virus as a novel oncolytic agent against hepatocellular carcinoma. Poster presentation at The 5 International Meeting on Replicating Oncolytic Virus Therapeutics. March 18-22, 2009, Banff, Canada.