Miracle-dz/UniFAR-FTUs huggingface dataset:
Performance comparison of five regression-based machine learning techniques for estimating load-carrying capacity of steel frame using direct analysis

The development of computer science has promoted the application of scientific and technological achievements to construction engineering in general and steel structure design in particular. Recently, the steel frame structure design has applied advanced analytical methods to take into account the inelastic behavior of the material and the geometric nonlinear properties of the structure, leading to the results obtained close to the real structure. In addition, to reduce computational time and effort, it has been applied advanced machine learning (ML) algorithms to predict behavior, helping to accelerate decision-making, improve efficiency, and reduce errors. In this paper, 5 popular machine learning algorithms are currently being conducted for the regression-based to estimate the ultimate load capacity of steel frames, including Linear Regression, Deep Learning, Support Vector Machine, Random Forest, and XGBoost. The effectiveness of applying these methods is tested through a numerical example surveying a 20-story space steel frame. The performance of ML algorithms is evaluated by comparing the mean-squared error (MSE) and computational efforts. The results show that among the 5 selected methods, the XGBoost has obvious advantages and is superior in terms of both MSE and calculation time.
Fermented camel milk influenced by soy extract: Apparent viscosity, Viscoelastic Properties, Thixotropic Behavior, and Biological Activities.

During fermentation, camel milk forms a fragile, acid-induced gel, which is less stable compared with the gel formed by bovine milk. In this study, camel milk was supplemented with different levels of soy extract, and the obtained blends were fermented with 2 different starter culture strains (CH and YF). The camel milk-soy extract yogurt treatments were evaluated for pH value, acidity, total phenolic compounds, antioxidant capacities, degree of hydrolysis, α-amylase and α-glucosidase inhibitions, angiotensin-converting enzyme inhibition, antiproliferative activities, and rheological properties after 1 and 21 d of storage at 4°C. The results revealed that some of the investigated parameters were significantly affected by the starter culture strain and storage period. For instance, the impact of starter cultures was evident for the degree of hydrolysis, antioxidant capacities, proliferation inhibitions, and rheological properties since these treatments led to different responses. Furthermore, the characteristics of camel milk-soy extract yogurt were also influenced by the supplementation level of soy extract, particularly after 21 d of storage. The findings of this study could provide valuable knowledge to the dairy industry since it highlighted the characteristics of camel milk-soy yogurt prepared with 2 different starter culture strains.
A Preliminary Study in Er:YAG Laser Debonding of Lithium Disilicate Crowns: Laser Power Setting vs Crown Thickness

Background: Er:YAG laser is widely used in debonding of all-ceramic veneers nowadays. However, the data about laser parameters in all-ceramic crown removal is limited. The aim of this preliminary study was to determine the most appropriate laser parameters at safe heat transmission values for lithium disilicate crowns in different thicknesses. Methods: Twenty-seven intact premolars were prepared to fabricate lithium disilicate CAD/CAM full-coverage crowns in three different thicknesses: 1, 1.5 mm, and mixed thickness (n=9). Each thickness group was divided into 3 subgroups and subjected to Er:YAG laser at different wattages (5, 5.6 and 5.9 W) to determine the appropriate wattage for each thickness. The removal time and temperature rise values were recorded. The Kruskal-Wallis test was performed to evaluate any significant differences in removal time, Mann-Whitney U test with Bonferroni correction for multiple comparisons, and the Pearson chi-square test for temperature rise over the critical value (p<0.05). Results: Laser irradiation at 5 W was safe and efficient for 1 mm thickness, while not efficient for others. Laser application at 5.9 W was efficient for all thicknesses, but, not safe for 1 mm thickness. The statistically significant difference in removal time was only between 5 W and 5.9 W groups (p=0.035). Pearson's chi-square test revealed that the temperature rise after 5.9 W laser application was significantly different from 5 W in 1 mm thickness group (p=0.043). Conclusion: Er:YAG laser lithium disilicate crown removal is an effective and safe method using laser settings appropriate for crown thickness.
Blocking gate resonator rasorber surface brings wide band electromagnetic absorption performance approaching theoretical limit

In wide band electromagnetic absorbers, absorption in high and low frequency domain usually influence each other. Rasorber structure with blocking gate resonator (BGR) sub‐wavelength unit surface is proposed and applied in electromagnetic wave absorber to resolve this problem. The absorber has −10 dB low‐reflectivity performance operating in bandwidth ratio 161.2% and approaches Rozanov's theory limit in low frequency. BGR unit surface also generate a 2‐step design method for multi‐layer absorber structure. Rasorber BGR unit surface helps to enhance low frequency absorption with limited thickness while maintain absorption in relative higher wide frequency range by impedance matching at low frequency. Sample fabrication and experiment measurement basically testify the numerical speculations.
Crawling Soft Robot Exploiting Wheel-Legs and Multimodal Locomotion for High Terrestrial Maneuverability

How to efficiently traverse complex terrain remains an unresolved challenge for mobile soft robots, because their deformable bodies limit the magnitude of the forces they can exert on the environment. To achieve high maneuverability, this article demonstrates a pneumatic soft crawling robot equipped with wheel-legs capable of multimodal locomotion to negotiate various obstacles. The soft robot consists of a pneumatic soft actuator capable of multiple modes of bending deformation as the body and four identical multispoked wheel-legs with passive unidirectional forward rotation as limbs. The synergy of the body actuator and wheel-legs enables the robot to achieve multiple crawling gaits, including gecko-like crawling and inchworm-like crawling. A single gait or a combination of multiple gaits, as well as shape-morphing of the body, enables the robot to navigate obstacles as diverse as confined spaces, inclined surfaces, gaps, and stairs, or to avoid obstacles by circumventing them. Our study substantially improves the maneuverability of pneumatic soft crawling robots, thereby providing new routes for the potential applications of soft robots in obstacle-filled scenarios, including search and rescue, exploration, and inspection.
Design Trends and Perspectives of Digital Low Dropout Voltage Regulators for Low Voltage Mobile Applications: A Review

Low-dropout (LDO) voltage regulator has fascinated industry professionals and academia for the past few decades, and this trend is expected to continue in the coming years. The high demand for a stable linear regulator architecture that performs well in systems-on-chip (SoC) power management integrated circuits (PMICs) is a key factor driving innovation with different complementary metal-oxide-semiconductor (CMOS) technologies. Yet, there are several performance parameter trade-offs to be considered, such as transient response, output ripple, area, power efficiency, supply voltage range, and current efficiency in the current LDO design architecture. All these parameter trade-offs become more severe during the back-end CMOS processes with additional limitations, for example, channel length modulation, stress sensitivity, and power leakage, among others. Therefore, this paper presents an overview and comparison of various digital LDO (DLDO) topologies, functionalities, and performance specifications, which can serve as a virtual study or reference for others.
Editorial: Insights in general cardiovascular medicine: 2022

COPYRIGHT © 2023 Acampa, Accioli, Salvini, Xiao and Lazzerini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
ANALISA KINERJA KEUANGAN PERUSAHAAN SEKTOR PROPERTI DAN REAL ESTAT PERIODE 2017-2021

Penelitian dilakukan untuk menganalisis lebih dalam mengenai kinerja perusahaan sektor properti dan real estat khususnya pada PT Lippo Karawaci Tbk, PT Kawasan Industri Jababeka Tbk, dan PT Pudjiadi Prestige Tbk di beberapa tahun terakhir. Industri sektor properti sangat penting dan dibutuhkan oleh masyarakat tanpa terkecuali, baik itu properti seperti pertokoan, perhotelan terlebih lagi perumahan atau tempat tinggal sehingga permintaannya akan terus naik sehingga penulis merasa perlu untuk meneliti kondisi perusahaan. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian kuantitatif dengan pendekatan deskriptif evaluatif menggunakan data sekunder. Peneliti akan menjelaskan lebih lanjut terkait dengan hasil pengolahan data-data yang berupa angka untuk mengetahui maksud dari angka tersebut. Hasil yang ditemukan yaitu dari ketiga perusahaan jika dilihat dari rasio likuiditasnya, maka PT Kawasan Industri Jababeka Tbk dinilai likuid dan memiliki kondisi yang paling aman dari masalah kesulitan membayar utang lancar. Sedangkan PT Lippo Karawaci jika melihat periode terakhir, maka perusahaan juga berada dalam kondisi likuid. Namun, PT Pudjiadi Prestige pada tahun 2021 masih dinilai tidak likuid. Namun jika dilihat dari rasio solvabilitasnya, dari ketiga perusahaan, PT Pudjiadi Prestige memiliki DAR yang paling rendah yaitu berkisar di angka 31%-39% pada periode penelitian. Sementara PT Lippo Karawaci memiliki rasio solvabilitas (DAR) paling tinggi yang terjadi pada tahun 2021 yaitu sebesar 57%. Jika kita melihat rata-rata industri, yakni 35%, debt to asset ratio dari ketiga perusahaan tersebut masih berada diatas rata-rata tersebut dimana hal tersebut akan membuat perusahaan mengalami kesulitan dalam memperoleh pinjaman. Sementara itu jika dilihat dari rasio profitabilitasnya, PT Pudjiadi Prestige Tbk dominan memiliki rasio yang paling tinggi (74%) dibandingkan dengan PT Lippo Karawaci Tbk dan PT Kawasan Industri Jababeka Tbk.
Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

DNA-dependent protein kinase (DNA-PK), a driver of the non-homologous end-joining (NHEJ) DNA damage response pathway, plays an instrumental role in repairing double-strand breaks (DSB) induced by DNA-damaging poisons. We evaluate ZL-2201, an orally bioavailable, highly potent, and selective pharmacologic inhibitor of DNA-PK activity, for the treatment of human cancerous malignancies. ZL-2201 demonstrated greater selectivity for DNA-PK and effectively inhibited DNA-PK autophosphorylation in a concentration- and time-dependent manner. Initial data suggested a potential correlation between ataxia-telangiectasia mutated (ATM) deficiency and ZL-2201 sensitivity. More so, ZL-2201 showed strong synergy with topoisomerase II inhibitors independent of ATM status in vitro. In vivo oral administration of ZL-2201 demonstrated dose-dependent antitumor activity in the NCI-H1703 xenograft model and significantly enhanced the activity of approved DNA-damaging agents in A549 and FaDu models. From a phosphoproteomic mass spectrometry screen, we identified and validated that ZL-2201 and PRKDC siRNA decreased Ser108 phosphorylation of MCM2, a key DNA replication factor. Collectively, we have characterized a potent and selective DNA-PK inhibitor with promising monotherapy and combinatory therapeutic potential with approved DNA-damaging agents. More importantly, we identified phospho-MCM2 (Ser108) as a potential proximal biomarker of DNA-PK inhibition that warrants further preclinical and clinical evaluation. Significance: ZL-2201, a potent and selective DNA-PK inhibitor, can target tumor models in combination with DNA DSB-inducing agents such as radiation or doxorubicin, with potential to improve recurrent therapies in the clinic.
Apelin Prevents and Alleviates Crystalline Silica-induced Pulmonary Fibrosis via Inhibiting Transforming Growth Factor Beta 1-triggered Fibroblast Activation

Silicosis is a common and ultimately fatal occupational disease, yet the limited therapeutic option remains the major clinical challenge. Apelin, an endogenous ligand of the G-protein-coupled receptor (APJ), is abundantly expressed in diverse organs. The apelin-APJ axis helps to control pathological and physiological processes in lung. The role of apelin in the pathological process and its possible therapeutic effects on silicosis have not been elucidated. In this study, we found that lung expression and circulating levels of apelin were markedly decreased in silicosis patients and silica-induced fibrotic mice and associated with the severity. Furthermore, in vivo data demonstrated that pre-treatment from day 3 and post-treatment from day 15 with apelin could both alleviate silica-induced pulmonary fibrosis in mice. Besides, apelin inhibited pulmonary fibroblast activation via transforming growth factor beta 1 (TGF-β1) signaling. Our study suggested that apelin could prevent and reverse silica-induced pulmonary fibrosis by inhibiting the fibroblast activation through TGF-β1 signaling pathway, thus providing a new potential therapeutic strategy for silicosis and other pulmonary fibrosis.
Detection of various fusion genes by one-step RT-PCR and the association with clinicopathological features in 242 cases of soft tissue tumor

Introduction: Over the past decades, an increasing number of chromosomal translocations have been found in different STSs, which not only has value for clinical diagnosis but also suggests the pathogenesis of STS. Fusion genes can be detected by FISH, RT-PCR, and next-generation sequencing. One-step RT-PCR is a convenient method to detect fusion genes with higher sensitivity and lower cost. Method: In this study, 242 cases of soft tissue tumors were included, which were detected by one-step RT-PCR in multicenter with seven types of tumors: rhabdomyosarcoma (RMS), peripheral primitive neuroectodermal tumor (pPNET), synovial sarcoma (SS), myxoid liposarcomas (MLPS), alveolar soft part sarcoma (ASPS), dermatofibrosarcoma protuberans (DFSP), and soft tissue angiofibroma (AFST). 18 cases detected by one-step RT-PCR were further tested by FISH. One case with novel fusion gene detected by RNA-sequencing was further validated by one-step RT-PCR. Results: The total positive rate of fusion genes was 60% (133/213) in the 242 samples detected by one-step RT-PCR, in which 29 samples could not be evaluated because of poor RNA quality. The positive rate of PAX3–FOXO1 was 88.6% (31/35) in alveolar rhabdomyosarcoma, EWSR1–FLI1 was 63% (17/27) in pPNET, SYT–SSX was 95.4% in SS (62/65), ASPSCR1–TFE3 was 100% in ASPS (10/10), FUS–DDIT3 was 80% in MLPS (4/5), and COL1A1–PDGFB was 66.7% in DFSP (8/12). For clinicopathological parameters, fusion gene status was correlated with age and location in 213 cases. The PAX3–FOXO1 fusion gene status was correlated with lymph node metastasis and distant metastasis in RMS. Furthermore, RMS patients with positive PAX3–FOXO1 fusion gene had a significantly shorter overall survival time than those patients with the negative fusion gene. Among them, the FISH result of 18 cases was concordant with one-step RT-PCR. As detected as the most common fusion types of AHRR–NCOA2 in one case of AFST were detected as negative by one-step RT-PCR. RNA-sequencing was used to determine the fusion genes, and a novel fusion gene PTCH1–PLAG1 was found. Moreover, the fusion gene was confirmed by one-step RT-PCR. Conclusion: Our study indicates that one-step RT-PCR displays a reliable tool to detect fusion genes with the advantage of high accuracy and low cost. Moreover, it is a great tool to identify novel fusion genes. Overall, it provides useful information for molecular pathological diagnosis and improves the diagnosis rate of STSs.
Community involvement in ocean policy: coastcare and the establishment of Marine Protected Areas in Australia

In the last decade, Australia's marine and coastal policy-makers have sought to involve both the broad community and specific stakeholders in the development of policy for the marine and coastal environments, and in the stewardship of these environments. Such community involvement can lead to capacity-building within agencies, stakeholder groups and the community at large. In this paper we review the recent history of marine and coastal policies in Australia and, using specific examples, show that five elements of capacity-building, namely integrative place-making, collaborative policy-making, inclusive stakeholder involvement, and building relational resources, have emerged to some extent in Australian coastal and marine policies of the 1990s. We suggest that opportunities exist for developing these elements further, and that the process of collaborative learning is one way to help achieve this.
Adaptively Addressing Uncertainty in Estuarine and Near Coastal Restoration Projects

Restoration projects have an uncertain outcome because of a lack of information about current site conditions, historical disturbance levels, effects of landscape alterations on site development, unpredictable trajectories or patterns of ecosystem structural development, and many other factors. A poor understanding of the factors that control the development and dynamics of a system, such as hydrology, salinity, wave energies, can also lead to an unintended outcome. Finally, lack of experience in restoring certain types of systems (e.g., rare or very fragile habitats) or systems in highly modified situations (e.g., highly urbanized estuaries) makes project outcomes uncertain. Because of these uncertainties, project costs can rise dramatically in an attempt to come closer to project goals. All of the potential sources of error can be addressed to a certain degree through adaptive management. The first step is admitting that these uncertainties can exist, and addressing as many of the uncertainties with planning and directed research prior to implementing the project. The second step is to evaluate uncertainties through hypothesis-driven experiments during project implementation. The third step is to use the monitoring program to evaluate and adjust the project as needed to improve the probability of the project to reach is goal. Themore » fourth and final step is to use the information gained in the project to improve future projects. A framework that includes a clear goal statement, a conceptual model, and an evaluation framework can help in this adaptive restoration process. Projects and programs vary in their application of adaptive management in restoration, and it is very difficult to be highly prescriptive in applying adaptive management to projects that necessarily vary widely in scope, goal, ecosystem characteristics, and uncertainties. Very large ecosystem restoration programs in the Mississippi River delta (Coastal Wetlands Planning, Protection, and Restoration Act; CWPPRA) have incorporated very specific and detailed elements in a more active adaptive management effort. In Puget Sound, the Puget Sound Action Team uses site-specific case studies, monitoring, and public involvement to direct actions to reduce microbial contamination of harvestable shellfish. Small-scale projects can also be improved through application of adaptive management. For example, directed research and site assessments resulted in successful restoration of seagrasses near a ferry terminal in Puget Sound. It is recommended that all restoration programs be conducted in an adaptive management framework, and where appropriate, a more active adaptive management approach be applied. The net effect should be less uncertainty, improved project success, advancement of the science of restoration, and cost savings. « less
338 to 335 Ma old intrusions in the Bohemian Massif: a relic ofthe orogen-wide durbachitic magmatism in European Variscides.

Zircons from durbachite and syenite samples, from Třebic and Jihlava massifs, were dated. Whereas the durbachite contains complex zircons and gives discordant U-Pb ages, the syenite contains rounded zircons, yielding concordant age of 335 Ma. Both rocks represent relics of the orogen-wide late Variscan magmatism, along with rocks from other parts of the Variscan belt in Europe.
Towards rigorous cross-national comparison of internal migration: who collects what?

Cross-national comparisons of internal migration can contribute significantly to understanding of mobility, but are hampered by differences in measurement and definition. Recent work (Bell et al 2002) examined the obstacles to such comparisons and proposed a battery of 15 migration indicators which were tested using British and Australian data. This paper provides the foundation for wider comparisons by assembling, for the first time, a comprehensive inventory of the internal migration data collected by UN member countries worldwide. Results are based on mining of web-based resources, published papers on migration and a global survey of national statistical agencies. The paper reports key findings including the types of data sources used to collect mobility data, the intervals over which migration is measured and the zonal systems employed, identifies commonalities and differences in practice between broad regions of the world, and assesses the implications for rigorous cross-national comparisons of mobility and internal migration.
Editorial: Comprehensive insights into mitral valve prolapse: from biology to future perspectives of treatment passing through diagnostic tools, surgical techniques, and transcatheter options

COPYRIGHT © 2023 Loardi, Zanobini and Tribouilloy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Formação Continuada: Integração das Tecnologias Digitais na Prática Pedagógica de Professores de Matemática

O presente artigo tem por objetivo realizar uma análise de como osprofessores de Matemática da educação básica, em processo de formação, podem aprimorar sua prática docente, levando em consideração o impacto das tecnologias digitais na sociedade e educação, especialmente em relação à mudança do papel do professor no ensino e aprendizagem. Durante o curso foram exploradas atividades, com a utilização do software Geogebra, envolvendo conteúdos de funções, geometria plana e geometria espacial, entre outros, bem como planejamento de atividades pelos participantes. A metodologia adotada foi a de pesquisa qualitativa com características de estudo de caso. Os instrumentos de coleta de dados foram questionários (um inicial e outro no final) e planos de aulas elaborados pelos docentes nos encontros, os quais geraram os dados discutidos neste artigo. Em decorrência da análise dos dados, percebeu-se que houve um aprimoramento dos conhecimentos dos sujeitos participantes desta pesquisa em relação à inserção do Geogebra na prática pedagógica. Assim, é possível observar que o curso de formação promoveu indícios de mudança de paradigmas na prática docente, mudanças essas que estão diretamente ligadas ao fomento da utilização das tecnologias digitais no cotidiano da sala de aula.