Miracle-dz/UniFAR-FTUs huggingface dataset:
COVID-19 Pandemic Impact on US Childhood Caries and Potential Mitigation

Non-Hispanic Black (NHB) and Hispanic and low-income US children have a higher prevalence of untreated caries than their higher-income and non-Hispanic White (NHW) counterparts. Due to the COVID-19 pandemic, many dental offices and school sealant programs closed beginning March 2020. We examine the effect of reduced access to restorative care and sealants on the oral health of children from low-income households overall and by race/ethnicity and how increased sealant delivery in September 2022 could mitigate these effects. We used Markov chain Monte Carlo simulation to model COVID-19’s impact on first permanent molar (1M) caries incidence and loss in quality of life (disability-adjusted life years [DALYs]) due to time lived with 1M untreated caries. Our model followed a cohort of children aged 7 y in March 2020 until February 2024. Model inputs were primarily obtained from published studies and nationally representative data. Excess DALYs per 1,000 children attributable to reduced access to care during the pandemic were 1.48 overall and greater for Hispanic (2.07) and NHB (1.75) children than for NHW children (0.94). Excess incidence of 1M caries over 4 y was 2.28 percentage points overall and greater for Hispanic (2.63) and NHB (2.40) children than for NHW (1.96) children. Delivering sealants to 50% of eligible 1Ms in September 2022 would not completely mitigate COVID-19’s health access impact: overall excess DALYs would decrease to 1.05, and absolute disparities in excess DALYs between NHW children and Hispanic and NHB children would remain but decrease by 0.38 and 0.33, respectively. Sealing 40% of eligible 1Ms, however, would bring overall 4-y caries incidence down to pre–COVID-19 levels and eliminate the differential effect of the pandemic on children from minority groups. The pandemic’s negative impact on the oral health of children from low-income households and increased disparities could be partially mitigated with increased sealant delivery.
Speech-language pathologists’ practices in augmentative and alternative communication during early intervention

Abstract This survey study examined augmentative and alternative communication (AAC) practices reported by early intervention speech-language pathologists (SLPs) across the United States (N = 376). The study examined (a) types of AAC that SLPs reported using (i.e., sign language, photographs, pictures, symbols, talking switches, and iPad apps or dedicated speech-generating devices); (b) SLPs’ perspectives on the influence of child spoken language ability on AAC recommendations; (c) factors that influenced AAC decision-making within early intervention; and (d) perceived barriers associated with AAC implementation. SLPs reported that they were significantly more likely to introduce all types of AAC to children without spoken language abilities compared to children in later stages of language development. On average, they were most likely to report using or recommending sign language and photographs, and least likely to report using or recommending talking switches or speech-generating devices. Of the options provided, child expressive and receptive language abilities were rated as the most important factors to consider when determining AAC use, followed by cognitive ability, diagnosis, and chronological age. SLPs identified caregiver buy-in and carryover across providers as the most significant barriers to AAC implementation. Recommendations for future research and current AAC practices within early intervention are discussed.
Caffeine Role in the Age-Related Neurodegenerative Diseases, A Review.

Caffeine, a simple purine alkaloid with the proper chemical name 1,3,7-trimethylpurine-2,6-dione, is an abundant compound contained in beverages like coffee, food and drugs. It interacts with various pathways of which antagonism of adenosine receptors is the most significant but the other physiological pathways can be influenced by caffeine as well. Interaction with glutamate and dopamine neurotransmission pathways, competition with other substrates on cytochrome P450, non-competitive inhibition of acetylcholinesterase, blocking of nicotinic acetylcholine receptor and competitive inhibition of cyclic nucleotide phosphodiesterase can be mentioned. Because of caffeine availability as a part of foods, beverages and drugs, it has practical relevance even if the effect is weak. Intake of coffee containing edibles for a long period or even for a substantial part of life makes caffeine´s impact significant. Low acute and chronic toxicity of caffeine is another important specification. The discoveries from the last few years point to the fact that caffeine would interfere with the progression of some age-related neurodegenerative disorders like Alzheimer and Parkinson diseases and dementia with Lewy bodies. In this review article, the recent findings about caffeine´s impact on neurodegenerative diseases are presented and important facts about the caffeine effect including the substantial discoveries are described.
Effects of Neural Mobilization on Pain Intensity, Disability, and Mechanosensitivity: An Umbrella Review with Meta-Meta-Analysis.

OBJECTIVE The purpose of this study was to assess the current evidence for the effects of neural mobilization (NM) treatments. METHODS Three umbrella reviews with meta-meta-analyses (MMAs) were conducted to determine the effects of NM on pain intensity and disability in people with musculoskeletal disorders and on mechanosensitivity in participants who were asymptomatic. The study used the grading criteria proposed by the Physical Activity Guidelines Advisory Committee to assess the quality of evidence. RESULTS One MMA revealed a statistically significant moderate effect on pain intensity (standardized mean difference [SMD] = -0.75; 95% CI = -1.12 to -0.38) but with evidence of heterogeneity (Q = 14.13; I2 = 65%). The study found a significantly large effect of NM on disability (SMD = -1.22; 95% CI = -2.19 to -0.26), again with evidence of heterogeneity (Q = 31.57; I2 = 87%). The third MMA showed a statistically significant moderate effect of NM on mechanosensitivity (SMD = 0.96; 95% CI = 0.35 to 1.57), with no evidence of heterogeneity (Q = 2.73; I2 = 63%). For all examined outcomes, the quality of evidence was limited. CONCLUSIONS Overall, the results indicated that although NM treatment had a moderate to large beneficial clinical effect on pain intensity and disability in people with musculoskeletal disorders and on mechanosensitivity in individuals who were asymptomatic, the quality of evidence was limited. IMPACT Neural mobilization treatments showed positive results on the pain intensity and disability in patients with musculoskeletal conditions. Neural mobilization could be integrated into the physical therapy management, although more research is needed.
Prevalence of smartphone addiction among Asian medical students: A meta-analysis of multinational observational studies

Background: High prevalence of smartphone addiction among medical students may contribute to adverse physical and mental health outcomes. Aim: To estimate the prevalence of smartphone addiction, and explore the influencing factors and related mental health symptoms of smartphone addiction among Asian medical students. Design: Systematic review and meta-analysis. Methods: PubMed (MEDLINE), the Cochrane Central Register of Controlled Trials, and EMBASE were searched for relevant literature from the inception to September 10, 2021. Using Stata software 11.0, the meta-analysis of prevalence and the influencing factors of smartphone addiction were determined with 95% confidence intervals. Results: Nineteen articles, published between 2014 and 2019, were included, producing medical student studies from seven different Asian countries. The included studies were conducted in India (n = 11) and Malaysia (n = 3), with China, Saudi Arabia, Turkey, Nepal, and Iran each contributing one study. Among a total of 5,497 medical students, the participants included 3,214 females, of whom 2,181 were medical students with smartphone addiction. The prevalence of smartphone addiction among Asian medical students was 41.93% (95% CI [36.24%, 47.72%]). The influencing factors of smartphone addiction among medical students included gender, duration of smartphone use, smartphone function, and marital status. Ten studies (52.63%) explored related mental health symptoms of smartphone addiction among Asian medical students. Smartphone addiction was positively correlated with poor sleep quality (r = .17–.31), stress (r = .30–.40), anxiety, depression, neuroticism, and general health among Asian medical students. Conclusion: Smartphone addiction is highly prevalent among Asian medical students. Smartphone addiction may adversely affect mental health, resulting in sleep disturbance, stress, anxiety, depression, and neuroticism. It is necessary to take appropriate precautionary actions and interventions to prevent smartphone overuse among medical students.
Neural mechanisms of the mood effects on third‐party responses to injustice after unfair experiences

Behavioral decision theory argues that humans can adjust their third‐party responses (e.g., punishment and compensation) to injustice by integrating unfair experiences. Typically, the mood plays an important role in such a decision‐making process. However, the underlying neurocognitive bases remain largely unclear. We first employ a modified third‐party justice game in which an allocator split an amount of money between oneself and a receiver. The participants can reapportion the money as observers by choosing from the following three costly options: compensate the receiver, accept the current allocation, or punish the allocator. Then, a second‐party pseudo interaction is conducted where participants receive more (i.e., advantageous unfair experience) or less (i.e., disadvantageous unfair experience) than others. Finally, participants perform the third‐party justice game again after unfair experiences. Here, we use functional near‐infrared spectroscopy (fNIRS) to measure participants' brain activities during third‐party responses to injustice. We find participants compensate more to the receiver after advantageous unfair experience, which involved enhanced positive emotion, weakened sense of unfairness, and is linked with increased activity in the right dorsolateral prefrontal cortex (rDLPFC). In contrast, participants punish more on the allocator after disadvantageous unfair experience, which might primarily stem from their negative emotional responses, strong sense of unfairness, and is associated with significantly decreased activity in the rDLPFC. Our results suggest that third‐party compensation and punishment involved differential psychological and neural bases. Our findings highlight the crucial roles of second‐party unfair experiences and the corresponding mood responses in third‐party responses to unfairness, and unravel the intermediate neural architecture.
Effects of full-threaded headless cannulated compression screws and anatomical plates on the efficacy, safety, and prognosis of patients with triplane fractures of the distal tibia.

OBJECTIVE To compare the clinical efficacy, safety, and prognosis of full-threaded headless cannulated compression screws (HCCSs) and anatomical plates (APs) in the treatment of triplane fractures of the distal tibia. METHODS In this retrospective study, 74 patients with triplane fractures of the distal tibia treated in our hospital from April 2017 to March 2019 were selected as the research subjects. Among them, 38 patients receiving full-threaded HCCSs were assigned to the research group (RG), and the remaining 36 patients receiving APs were assigned to the control group (CG). The general indices, including operation, fracture healing, and ambulation times, efficacy, and complications were recorded and compared between the two groups. Visual analogue scale (VAS) was applied to assess pain, and a quality of life (QOL) survey was conducted at 6 months after surgery. RESULTS Compared with the CG, the operation time, fracture healing time, and ambulation time of the RG were significantly shortened (P<0.05). The proportion of patients with excellent and good outcomes and Mazur Scores in the RG were higher than those in the CG (P<0.05). The frequency of complications in the RG was lower than that in the CG (P<0.05). The preoperative VAS score did not exhibit significant differences between the two groups (P<0.05), but the scores in the RG at T1 and T2 were significantly lower than those in the CG (P<0.001). The QOL score in the RG (76.17±8.57) was also significantly higher than in the CG (71.54±8.02) (P<0.05). CONCLUSION Full-threaded HCCSs are more effective and safer than APs and can effectively improve the prognosis of patients with triplane fractures of the distal tibia.
Predictors of psychological stress in silica‐exposed workers in the artificial stone benchtop industry

Artificial stone benchtops are a popular kitchen product, but dust from their preparation and installation contains respirable crystalline silica, which causes silicosis. Silicosis is a preventable, permanent lung disease. The aim of this study was to assess mental health in workers from the artificial stone benchtop industry at risk of silicosis.
Optimising the process parameters of selective laser melting for the fabrication of Ti6Al4V alloy

Surface roughness is an important evaluation index for industrial components, and it strongly depends on the processing parameters for selective laser molten Ti6Al4V parts. This paper aims to obtain an optimum selective laser melting (SLM) parameter set to improve the surface roughness of Ti6Al4V samples. ,A response surface methodology (RSM)-based approach is proposed to improve the surface quality of selective laser molten Ti6Al4V parts and understand the relationship between the SLM process parameters and the surface roughness. The main SLM parameters (i.e. laser power, scan speed and hatch spacing) are optimized, and Ti6Al4V parts are manufactured by the SLM technology with no post processes. ,Optimum process parameters were obtained using the RSM method to minimise the roughness of the top and vertical side surfaces. Obtained parameter sets were evaluated based on their productivity and surface quality performance. The validation tests have been performed, and the results verified the effectivity of the proposed technique. It was also shown that the top and vertical sides must be handled together to obtain better top surface quality. ,The obtained optimum SLM parameter set can be used in the manufacturing of Ti6Al4V components with high surface roughness requirement. ,RSM is used to analyse and determine the optimal combination of SLM parameters with the aim of improving the surface roughness quality of Ti6Al4V components, for the first time in the literature. Also, this is the first study which aims to simultaneously optimise the surface quality of top and vertical sides of titanium alloys.
The Role of Prosody in Disambiguating English Indirect Requests

Ambiguity pervades language. The sentence “My office is really hot” could be interpreted as a complaint about the temperature or as an indirect request to turn on the air conditioning. How do comprehenders determine a speaker’s intended interpretation? One possibility is that speakers and comprehenders exploit prosody to overcome the pragmatic ambiguity inherent in indirect requests. In a pre-registered behavioral experiment, we find that human listeners can successfully determine whether a given utterance was intended as a request at a rate above chance (55%), above and beyond the prior probability of a given sentence being interpreted as a request. Moreover, we find that a classifier equipped with seven acoustic features can detect the original intent of an utterance with 65% accuracy. Finally, consistent with past work, the duration, pitch, and pitch slope of an utterance emerge both as significant correlates of a speaker’s original intent and as predictors of comprehenders’ pragmatic interpretation. These results suggest that human and machine comprehenders alike can use prosody to enrich the meaning of ambiguous utterances, such as indirect requests.
Thinking about neither death nor poverty affects delay discounting, but episodic foresight does: Three replications of the effects of priming on time preferences

We outline three attempts to replicate experiments that reported priming effects on time preferences measured by delay discounting. Experiment 1 tested the claim that images of poverty prime impulsive choice in people from less affluent backgrounds compared with people from more affluent backgrounds. Experiment 2 tested the claim that mortality salience—thinking about death—primes people to place more value on the future than people who thought about dental surgery. Experiment 3 tested the claim that an episodic foresight manipulation primes greater discounting than no episodic foresight. Experiments 1 and 2 failed to replicate the effects of priming on discount rates. Experiment 3 was a successful and very close replication of the effect of episodic foresight on discount rates.
Design of access control system based on low-voltage power line communication

Through the analysis of present access control system,this paper proposes a new access control system based on low-voltage power line communication technology.It puts forward the system topology and the structure diagram,analyses the characteristic of the system,discusses the design process of software and hardware.A communication protocol is designed according to the system characters The application proves that the access control system has the advantages of lower costs and higher flexibility and reliability.
The significance of mixed chimaerism and cell lineage chimaerism monitoring in paediatric patients post haematopoietic stem cell transplant

Haematopoietic stem cell transplants (HSCTs) are carried out across the world to treat haematological and immunological diseases which would otherwise prove fatal. Certain diseases are predominantly encountered in paediatric patients, such severe primary immunodeficiencies (PID) and diseases of inborn errors of metabolism (IEM). Chimaerism testing for these disorders has different considerations compared to adult diseases. This review focuses on the importance of cell‐lineage‐specific chimaerism testing and examines the appropriate cell populations to be assessed in individual paediatric patient groups. By analysing disease‐associated subpopulations, abnormalities are identified significantly earlier than in whole samples and targeted clinical decisions can be made. Chimaerism methods have evolved over time and lead to an ever‐increasing level of sensitivity and biomarker arrays to distinguish between recipient and donor cells. Short tandem repeat (STR) is still the gold standard for routine chimaerism assessment, and hypersensitive methods such as quantitative and digital polymerase chain reaction (PCR) are leading the forefront of microchimaerism testing. The rise of molecular methods operating with minute DNA amounts has been hugely beneficial to chimaerism testing of paediatric samples. As HSCTs are becoming increasingly personalised and risk‐adjusted towards a child's individual needs, chimaerism testing needs to adapt alongside these medical advances ensuring the best possible care.
Medicinal plants mediated the green synthesis of silver nanoparticles and their biomedical applications

Abstract The alarming effect of antibiotic resistance prompted the search for alternative medicine to resolve the microbial resistance conflict. Over the last two decades, scientists have become increasingly interested in metallic nanoparticles to discover their new dimensions. Green nano synthesis is a rapidly expanding field of interest in nanotechnology due to its feasibility, low toxicity, eco‐friendly nature, and long‐term viability. Some plants have long been used in medicine because they contain a variety of bioactive compounds. Silver has long been known for its antibacterial properties. Silver nanoparticles have taken a special place among other metal nanoparticles. Silver nanotechnology has a big impact on medical applications like bio‐coating, novel antimicrobial agents, and drug delivery systems. This review aims to provide a comprehensive understanding of the pharmaceutical qualities of medicinal plants, as well as a convenient guideline for plant‐based silver nanoparticles and their antimicrobial activity.
The 16α‐Hydroxylation of Progesterone by Cytochrome P450 107X1 from Streptomyces avermitilis

Cytochrome P450 enzymes (CYPs or P450s) are ubiquitous heme‐dependent enzymes that catalyze the monooxygenation of non‐activated C−H bonds to modify the structure of the substrate. In this study, we heterologously expressed CYP107X1 from Streptomyces avermitilis and conducted in vitro substrate screening using the alternative redox partners putidaredoxin and putidaredoxin reductase. CYP107X1 catalyzed the 16α‐hydroxylation of progesterone with regio‐ and stereoselectivity. The spectroscopic analyses showed that CYP107X1 bound progesterone with a relatively high Kd value of 65.3±38.9 μM. The Km and kcat values for progesterone were estimated to be 47.7±12.0 μM and 0.30 min−1, respectively. Furthermore, a crystal structure was obtained of CYP107X1 bound with glycerol from the buffer solution. Interestingly, a conserved threonine was replaced with asparagine in CYP107X1, indicating that it may adopt an unnatural proton transfer process and play a crucial role in its catalytic activity.
PENGKAJIAN PENERAPAN PENGENDALIAN HAMA ULAT, Spodoptera exiqua PADA USAHATANI BAWANG MERAH DI SERANG, BANTEN

Pest is one of the limiting factors in shallots cultivation.To overcome pest problems, shallots farmers generally use pesticides intensively. These circumstance led the increase of production costs and inefficient on shallots cultivation. One effort is to reduce production costs and the use of pesticides with the application of pest control threshold. Study of determination of control threshold on shallots cultivation was carried out at Kramatwatu Subdistrict, Serang District, Banten Province, in November until December 2014. Three treatments tested in the experiment, namely (A). S.exiqua moth caugth > 10 individu per day, (B). Plant damage of 5%, (C). application of pestiscide every 3 days. The experiment used a randomiced block design and each treatment was repeated eight times. Results showed that control threshold based on the the catch of the mouth > 10 per day gave shallots yields of 14.78 t/ha and benefit of Rp. 99.780. 000/ha with the value of B/C ratio of 2,07. In the treatment of B, based on crop damage the yield was 12.20 t/ha and benefit of Rp 69.780. 000/ha was obtained with B/C 1.38; while in treatment C, application of pesticides every 3 days yielded 11.40 t/ha and gave benefit of Rp 62.080. 000/ha with B/C at 1.19. Implementation on the control threshold, was economically feasible to adopted because it can inrease the yield and net benefits compared to the system of pest routinely aplied every 3 days and plant damage 5%. Key Words: Spodoptera exiqua, control threshold, benefits