Miracle-dz/UniFAR-FTUs huggingface dataset:
The 3D finite element analysis of stress distribution in implant supported single crown with different abutment designs

At present, various implant abutments are available, but the effect of abutment design on the implant and surrounding bone of an implant supported single crown in the posterior region is limited. The purpose of this study was to investigate the maximum von Mises stress, stress distribution pattern and stress accumulation of implant supported by a single crown with various abutment designs in the posterior region. A dental implant (4.5 mm in diameter and 11.5 mm in length), with three different implant abutments, i.e., Rigid, Transfer, and customized titanium abutments, with zirconia crowns, were modeled using geometric data in SolidWorks. ANSYS software was used for analysis of applied loads (200 N vertical and 40 N horizontal) at a functional area with 1 Hz for 5 seconds. The results showed that the patterns of stress distribution in all models were similar, i.e., the maximum von Mises stresses were observed at the first thread of the implant fixture on the buccal side. In the bone, the maximum stress was observed at the marginal bone contact area with the first thread of the implant. The stress was concentrated at the implant fixture-abutment screw interface in the bottom area on the buccal side. The model with a customized abutment (model 3) had a lower maximum von Mises stress, compared with the prefabricated abutment models (models 1 and 2) in all components except the abutment. A customized titanium abutment can provide better biomechanics than a prefabricated abutment. There is a lower maximum stress with a continuous stress distribution pattern, and the stress accumulation is less in the implant fixture. The stress in the abutment screw was distributed continuously with less stress concentration, and the stress is distributed uniformly to the bone with a low stress value.
Updates on classification and management of status epilepticus

Background: Status epilepticus (SE) is a major medical emergency and requires not only an emergency symptomatic treatment with antiepileptic drugs (AED) but also a rapid identification and treatment of the underlying cause. This narrative review summarizes the most important advances in SE classification and treatment. Data sources included being PubMed / Medline, and tracking references of the relevant studies, reviews and books. SE is now defined as “a condition resulting either from the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms, which lead to abnormally prolonged seizures (after time point t1). It is a condition, which can have long-term consequences (after time point t2), including neuronal death, neuronal injury, and alteration of neuronal networks, depending on the type and duration of seizures. ” The most effective acute treatments for early SE are the intravenous benzodiazepines (lorazepam, diazepam, and clonazepam) and intramuscular midazolam. In children, oral or intranasal midazolam are useful alternatives. The intravenous antiepileptic drugs (phenytoin, valproate, levetiracetam, phenobarbital and lacosamide) are administered in confirmed SE. Treatment options in refractory SE are intravenous anesthetics; ketamine, magnesium, steroids and other drugs are used in super-refractory SE , showing variable results and outcomes. Conclusions: Over time, major progress has been made in defining, classifying, and understanding of SE mechanisms. Despite this, the first-line drug management is ineffective in up to 40% of patients with SE. The super-refractory SE treatment is still unknown and no evidence-based data have been found yet. Thus, SE treatment strategies vary substantially from one institution to another due to the lack of data supporting a specific treatment plan.
Real-time demand response and intelligent direct load control

The electricity markets have been suffering profound changes over the years. Nowadays, the European Union comes to reformulate its politics related with renewable energy sources, in order to encourage microgeneration, having demand response as one of the biggest challenges. Various simulators have been developed that intend to give decision support to the various entities. However, they present the limitation of being designed to answer specific problems. This paper proposes the framework Tools Control Center (TOOCC) as the mechanism to integrate various independent and heterogeneous simulators, so they operate as a unique simulation tool and become capable of answering to more complex problems
Determination of optimal support locations to maximize fundamental frequency of printed circuit boards

Printed circuit boards (PCB) are critical components in many aerospace applications. In these applications harsh dynamic environments, such as shock and vibration, are encountered and it is critical that the electronic assemblies endure these conditions. An ef-fective method for minimizing the detrimen-tal impact of these conditions on a PCB is to increase the lowest natural frequency of the PCB through the use of structural supports. In this report we describe a global optimization method, based on surrogate models, that was found to be eﬀective at ﬁnding optimal support locations on a PCB. Using a global optimization method within the DAKOTA optimization solver, wrapping a smooth-spline based ﬁnite element software, proves eﬀective at handling unreliable gradients and multi-modal solution space.
NONEQUILIBRIUM AND CLASSICAL DISSIPATION SCALINGS IN DNS OF HOMOGENEOUS ISOTROPIC DECAYING TURBULENCE

We present data from direct numerical simulations of homogeneous isotropic decaying turbulence showing both the non-equilibrium and the classical dissipation scalings reported in wind-tunnel experiments of both regular and fractal grid-generated turbulence, i.e. C ε ∼ ( Re 0 /Re λ ) n with n of order unity and C ε ∼ constant , respectively ( Re 0 and Re λ are global and local Reynolds numbers). These two dissipation behaviours lead to different power-law decay exponents in both regimes also in accord with the experiments. Finally, we show that in both regimes the maximum non-linear energy cascade ﬂux, Π , reasonably satisﬁes the classical expectation that Π ∼ K 3 / 2 /ℓ .
3D Face Recognition System in Time Critical Security Applications

: 3D face recognition has gained lot of attention due to improved sensors and advanced algorithms, deployment of this modality in biometrics systems is common now days. This paper presents the application of Region based 3D face recognition system. Region based face recognition system works by extracting 15 small regions from the frontal face; Modified face recognition algorithm along with hierarchical contour based registration technique is applied for finding similarity. We are operating this system in two modes namely the verification mode and the confirmation mode. The approaches employed is Distributed computing which gives more insight into the implementation of the system in time critical applications.
EFFECT OF ACORUS CALAMUS, BIOSAL ® AND DELTAMETHRIN ON FECUNDITY OF CALLOSOBRUCHUS ANALIS

Effect of two phytopesticides, Acorus calamus (AC) essential oil, Biosal ® (Neem formulation = NF Neem pesticide registered by APTA) and Deltamethrin (synthetic) was observed after 15 days of treatment by direct application method (DAM). The LC 50 dose was used for three compounds 0.15608 µl/cm 2 for Acorus calamus , 1.338504 µl/cm 2 for Biosal ® and 0.03352 µl/cm 2 for Deltamethrin. Emergence was observed by (DAM) in control and treated the fecundity of three compounds 62.5% and 58.33% by Acorus calamus , 72% and 67.74% by Biosal and 78.94% and 50.79% by Deltamethrin. worked on the suspectibility of C. maculates . Jayakumar (2010) studied the oviposition determence on cowpea vigna ungulate (L.) against C.maculates using phytopesticide. The present work on fecundity effect of phytopesticides Acorus calamus , Biosal as compared to synthetic pesticide Deltamethrin. The phytopesticides are easily available in Pakistan and others parts of the world, and these pesticides may be stored for a long time at normal room temperature. Synthetic and commercial pesticides are hazardous not only beneficial insects but also for environment and specially for human. Therefore present study is a search of phytopesticide.
University of Birmingham Action reprogramming in Parkinson's disease

Humansareabletouseknowledgeofpreviouseventstoestimatetheprobabilityoffutureactions.Consequently,anunexpectedeventwill elicitapredictionerrorasthepreparedactionhastobereplacedbyanunpreparedoptioninaprocessknownas“actionreprogramming” (AR). HereweshowthatpeoplewithParkinson’sdisease(PD)haveadopamine-sensitivedeficitinARthatisproportionaltothesizeof thepredictionerror.Participantsperformedaprobabilisticreactiontime(RT)taskinthecontextofeitherapredictableorunpredictable environment.Foranoverallpredictablesequence,PDpatients,onandoffdopaminemedication,andhealthycontrolsshowedsimilar improvementsinRT.However,inthecontextofagenerallypredictablesequence,PDpatientsoffmedicationwereimpairedinreacting tounexpectedeventsthatelicitlargepredictionerrorsandrequireAR.Critically,thisdeficitinARwasmodulatedbythepredictionerror associatedwiththeupcomingevent.TheprolongationofRTwasnotobservedduringanoverallunpredictablesequence,inwhich relativelyunexpectedeventsevokelittlepredictionerrorandtherequirementforARshouldbeminimal,giventhecontext.Thedataare compatiblewithrecenttheoreticalaccountssuggestingthatlevelsofdopamineencodethereliability,i.e.,precision,ofsensoryinforma-tion.Inthisscheme,PDpatientsoffmedicationhavelowdopaminelevelsandmaythereforebelessconfidentaboutincomingsensory informationandmorereliantontop-downpredictions.Consequently,whentheseinternalpredictionsareincorrect,PDpatientstake longertorespondappropriatelytounexpectedsensoryinformation.
Towards an Agent-Based Foundation of Financial Econometrics: An Approach Based on Genetic-Programming Arti(cid:12)cial Markets

Using a few nonlinear econometric tools, this paper examines some time-series properties of GP-based arti(cid:12)cial markets. We (cid:12)nd that GP-based arti(cid:12)cial markets are able to replicate several stylized features well documented in (cid:12)nancial econometrics. In particular, the time series generated by the GP-based arti(cid:12)cial markets are consistent with the eÆcient market hypothesis in the linear sense. Furthermore, the emergence of these stylized features may be caused by some institutional factors, such as position limits and transaction factors. By introducing the complexity of evolved GP-trees, a bottom-up analysis of the impact of transaction taxes on GP-based arti(cid:12)cial markets is also provided.
Pathological complete response to preoperative anthracycline-b ased chemotherapy in operab le b reast cancer: the pred ictive role of p53 ex pression

The aim of this retrospective study w as to identify m arkers capable of predicting pathological com plete (pCR) and overall clinical tum our response to preoperative anthracycline-based chem otherapy and clinical outcom e in w om en w ith operable breast cancer.Therefore, w e used the pre-treatm ent core biopsies from 107 patients w ho w ere enrolled in the EORTC trial 10902 to analyse tum our characteristics and the oncogenic m arkers bcl-2 , p53 , ER, PgR, H ER2 , and p21 . Median follow -up w as 7 years (95% confidence interval [CI], 6.89-7.45). pCR w as seen in seven patients (6.5% ) and w as associated w ith im proved overall survival (hazards ratio, 0.39; 95% CI, 0.05-2.56; P = 0.30). In m ultivariate logistic regression analysis, pCR w as independently predicted by p53 overexpression estim ated by im m unohistochem istery (odds ratio [OR], 16.83; 95% CI, 1.78-159.33; P = 0.01). Fifty-eight patients show ed clinical tum our response (>50% decrease in tum our size), how ever responders experienced no benefit in clinical outcom e. Clinical tum our response w as independently predicted by p53 overexpression (OR, 5.57; 95% CI, 1.58-19.65; P = 0.008) and sm all clinical tum our size (OR, 10.26; 95% CI, 2.01-52.48; P= 0.005). In m ultivariate Cox regression analysis, negative pathological lym ph node status, low tum our grade and use of tam oxifen show ed im proved overall survival. In conclusion, our data suggest p53 expression is of predictive significance in anthracycline containing chem otherapeutic regim ens.
What’s on the menu? Today’s specialty: a European networked university

In the midst of one of the greatest challenges ever faced, the great demand for learning, educational organizations are being reformed. The MENU consortium is working on meeting this challenge by creating a European Networked University (ENU). This paper provides a macroscopic view of the process of creating such aon organization. It describes the concerns that have to be taken into account and it presents the strategy of ENU. It also identifies ENU customers as well as competitors and articulates where ENU is going and why. Most importantly, it presents the business processes that ENU shall carry out.
Using Wearable Monitors to Assess Daily Walking Limitations Induced by Ischemic Pain in PAD

PURPOSE: To develop, assess the feasibility of, and determine the clinical validity of an event-based analysis method using wearable monitors to quantify walking pain manifestations (WPMs) and stops induced by walking pain (SIWPs) during daily life walking in people with peripheral artery disease (PAD). METHODS: The following two walking conditions were studied: a standardized outdoor walking session (OWS) and a 7-day free-living measurement (FLM) period. The PAD participants (n=23) wore an accelerometer and a watch. They were asked to press the event marker button on the watch to indicate events related to WPMs and SIWPs. To assess the clinical validity of the method, the computed pain-free walking time (PFWT) and maximal walking time (MWT) were compared to the PFWT and MWT assessed using standard treadmill walking protocols, respectively. RESULTS: Following OWSs, the PFWT [OWS] and MWT [OWS] were significantly correlated with the PFWT [Strandness] (r=0.955, P<0.001) and MWT [Strandness] (r=0.821, P<0.001), respectively. During the FLM, PAD participants experienced only 2 WPMs/day and 1 SIWP/day, although severely limited on the treadmill and during the OWS. The average WPMs/day were moderately correlated with the PFWT [Strandness] (r=-0.54, P=0.016). The PFWT [FLM] was on average 12 times longer than the PFWT [Strandness] . Interestingly, the intensity of the walking bouts as assessed by the accelerometer counts during the FLM was significantly lower than that during the OWS (45±15 vs. 66±21 counts/s, P<0.001). CONCLUSION: This new method provides perspectives for studies investigating the experience of living with PAD and the assessment of daily life walking capacity for both diagnostic and therapeutic purposes.
The Isolation and Characterization of Phosphate Solubilizing Bacteria from the Onion Rhizosphere and Their Effect on Onion Growth

In this study 269 phosphate solubilizing bacteria (PSB) strains were isolated from onions rhizosphere. The 15 most efficient PSB were selected. Based on BIOLOG profiling and the LOPAT test system, the strains were identiﬁed as Enterobacter cloacae (7), Yersinia intermedia, Pantoea agglomerans, Bacillus subtilis(2), Bacillus pumilius, Lysinibacillus sphaericus and Bacillus atrophaeus(2). The PSB effect on onion growth was investigated under greenhouse conditions. These PSB increased plant height (11.7 to 38.8%), the number of leaves (3 to 70%), the bulb diameter (6.4 to 64.5%), the average root length (2.6 to 44.7%), the fresh weight of the bulb (2.9 to 34.1%) and the dry weight of the bulb (1.5 to 40.6%) when compared to the negative control. Among these strains the most effective inoculants were the highest P solubizing E.cloacae EB-14 and E. cloacae OB-169 strains, which significantly increased all parameters compared to the commercial plant activator ISR 2000. These results demonstrated the potential use of these PSB as inoculants for onion growth.
The Dynamics of Galactic Satellites: Links to Galaxy Formation

We calculate orbits for the Milky Way dwarf galaxies with proper motions, and compare these to subhalo orbits in a high-resolution cosmological simulation. We use the simulation data to assess how well orbits may be recovered in the face of measurement errors, a time-varying triaxial gravitational potential and satellite–satellite interactions. For present measurement uncertainties, we recover the apocentre r a and pericentre r p to ∼ 40 per cent. With improved data from the Gaia satellite we should be able to recover r a and r p to ∼ 14 per cent, respectively. However, recovering the 3D positions and orbital phase of satellites over several orbits is more challenging. This owes primarily to the non-sphericity of the potential and satellite interactions during group infall. Dynamical friction, satellite mass-loss and the mass evolution of the main halo play a more minor role in the uncertainties. We apply our technique to nine Milky Way dwarfs with observed proper motions. We show that their mean apocentre is lower than the mean of the most massive subhaloes in our cosmological simulation, but consistent with the most massive subhaloes that form before z = 10. This lends further support to the idea that the Milky Way’s dwarfs formed before reionization.
CMAR_A_267665 7539..7552

Department of Breast Surgery, The First People's Hospital of Jingzhou, Jingzhou, Hubei, 434000, People’s Republic of China Purpose: Long intergenic non-coding RNA 922 (LINC00922) plays a critical role in the progression of lung cancer. In this study, we aimed to quantify LINC00922 expression in breast cancer and determine its influence on the malignant behavior of breast cancer cells in vitro and in vivo. We also investigated the mechanism by which LINC00922 affects the progression of breast cancer. Materials and Methods: Reverse transcription-quantitative polymerase chain reaction was performed to quantify LINC00922 expression in breast cancer tissues and cell lines. The cell counting kit-8 assay, flow cytometry, Transwell migration and invasion assays, and tumor model assays were performed to determine the effects of LINC00922 deficiency on breast cancer cell proliferation, apoptosis, migration and invasion in vitro, and tumor growth in vivo, respectively. Furthermore, bioinformatics analysis was performed to predict the potential target microRNA of LINC00922. The prediction was further evaluated using luciferase reporter and RNA immunoprecipitation assays. Results: LINC00922 was clearly overexpressed in breast cancer tissues and cell lines. LINC00922 depletion restricted breast cancer cell proliferation, migration, and invasion but induced cell apoptosis in vitro. Additionally, its knockdown evidently repressed tumor growth of breast cancer cells in vivo. Mechanistically, LINC00922 was demonstrated to serve as a molecular sponge for miR-424-5p in breast cancer cells. Furthermore, brainderived neurotrophic factor (BDNF) was verified as a direct target of miR-424-5p in breast cancer cells, and BDNF expression was found to be positively regulated by LINC00922 through sponging miR-425-5p. Rescue experiments further revealed that the influences on breast cancer cell proliferation, apoptosis, migration, and invasion induced by LINC00922 silencing were abrogated by increasing the output of the miR-424-5p/BDNF axis. Conclusion: The LINC00922/miR-424-5p/BDNF pathway is implicated in the acceleration of the malignant behavior of breast cancer cells. These findings suggest that this pathway is a promising novel molecular target in breast cancer therapy.
Modelling of AIDs Disease Associated Risk Factors and Mortality in Gamo Gofa Zone, Ethiopia

: Acquired Immune Deficiency Syndrome (AIDs) which is believed to be caused by the Human Immunodeficiency Virus (HIV) has been the major problem worldwide. The target population for this study was recorded patients of laboratory confirmed HIV/AIDs patients at Arba Minch Referral Hospital. ASRS method was adopted for selecting a representative sample of the patients based on their ART unique identification number/card for a cohort of patients from 1997 - 2005. Hence, the sample size with N = 2447 was n = 136. This study was aimed to estimate time to death of HIV/AIDs patients and determine significant risk factors for the survival times at Arba Minch Referral Hospital, Gamo Gofa Zone, Ethiopia. The findings based on semi parametric survival regression model on the data of AIDs patients reviled that the major risk factors determining the survival time are initial weight, past opportunistic infection, DM status, CD4 count, WHO clinical stage and adherence level. Butthe covariate sex, age, TB status and regimen were not significant factors. This study recommends Stakeholders, public health policy makers, researchers and the public at large, brings HIV/AIDs diseases and other chronic diseases to their agenda, so that appropriate prevention and control strategies are implemented along with a population wide surveillance intervention. Health care workers should anticipate and inform patients about the possible related risk factors of death through early diagnosis and appropriate intervention. Donors and government should understand the risk factors that influence the death of AIDs patients.
The Microenvironment as a Target for Therapy in Chronic Lymphocytic Leukemia

One of the hallmarks of malignant cells is the deregulation of their growth, survival and differentiation. In the case of Chronic Lymphocytic Leukemia (CLL), cellular physiology is regulated, to a large extent, by micro environmental elements that operate within the bone marrow and secondary lymphoid tissues. Extracellular cues that are vital for CLL cells survival and proliferation are exerted by interactions of CLL cells with accessory cells such as T-cells, mesenchymal stromal cells, endothelial cells, follicular dendritic cells and macrophages. CLL cells interact directly with effect or cells via a variety of adhesion molecules, while cytokines, chemokines, enzymes and growth factors provide a complex soluble regulatory network. The B-cell receptor (BCR) is the central source of signals that regulate CLL cells physiological responses. These signals can be triggered by the engagement of the receptor by extracellular antigens of either of microbial origin or auto antigens. Alternatively, as has been revealed in the recent years, the BCR can be activated by ligand-independent cell-autonomous signaling mechanisms. Due to its prime importance in CLL physiology, the biochemical array that mediates micro environmental-derived signaling responses in CLL cells became a useful target for the development of novel effective therapeutics. For example, small molecule inhibitors of SYK, BTK, or PI3Kб, all participate in BCR signaling responses, have shown remarkable Clinical effects. Also, BCL-2 inhibitors and immune modulatory drugs are being tested in clinical trials in CLL, with encouraging results. Hence, better understanding of CLL cells’ interaction with the microenvironment can continuously provide clinicians with novel effective therapeutics to control CLL. this