Miracle-dz/UniFAR-FTUs huggingface dataset:
Post-ischemic reorganization of sensory responses in cerebral cortex

Introduction Sensorimotor integration is critical for generating skilled, volitional movements. While stroke tends to impact motor function, there are also often associated sensory deficits that contribute to overall behavioral deficits. Because many of the cortico-cortical projections participating in the generation of volitional movement either target or pass-through primary motor cortex (in rats, caudal forelimb area; CFA), any damage to CFA can lead to a subsequent disruption in information flow. As a result, the loss of sensory feedback is thought to contribute to motor dysfunction even when sensory areas are spared from injury. Previous research has suggested that the restoration of sensorimotor integration through reorganization or de novo neuronal connections is important for restoring function. Our goal was to determine if there was crosstalk between sensorimotor cortical areas with recovery from a primary motor cortex injury. First, we investigated if peripheral sensory stimulation would evoke responses in the rostral forelimb area (RFA), a rodent homologue to premotor cortex. We then sought to identify whether intracortical microstimulation-evoked activity in RFA would reciprocally modify the sensory response. Methods We used seven rats with an ischemic lesion of CFA. Four weeks after injury, the rats’ forepaw was mechanically stimulated under anesthesia and neural activity was recorded in the cortex. In a subset of trials, a small intracortical stimulation pulse was delivered in RFA either individually or paired with peripheral sensory stimulation. Results Our results point to post-ischemic connectivity between premotor and sensory cortex that may be related to functional recovery. Premotor recruitment during the sensory response was seen with a peak in spiking within RFA after the peripheral solenoid stimulation despite the damage to CFA. Furthermore, stimulation in RFA modulated and disrupted the sensory response in sensory cortex. Discussion The presence of a sensory response in RFA and the sensitivity of S1 to modulation by intracortical stimulation provides additional evidence for functional connectivity between premotor and somatosensory cortex. The strength of the modulatory effect may be related to the extent of the injury and the subsequent reshaping of cortical connections in response to network disruption.
Cardiac Structure and Function in Young Adults With Various Cardiometabolic Profiles

Background Cardiovascular diseases are a leading cause of mortality worldwide. Cardiometabolic abnormalities result in alterations in the myocardial structure and function. Limited data are available on these changes in young adults with various cardiometabolic risk profiles. The goal was to study the relationship between cardiometabolic risk and echocardiographic changes in young patients of both sexes in a Russian population, using a risk-based cardiometabolic disease staging (CMDS) system. Methods A total of 191 patients were included. The patients were classified into five groups based on the CMDS system. We gathered patient history and performed a physical exam, biochemical blood analysis, and echocardiography. Statistical analyses were performed using IBM SPSS Statistics for Windows, Version 23 (Released 2015; IBM Corp., Armonk, New York, United States). Results The median age of the participants was 35 (30.0-39.0) years. Elevated systolic and diastolic blood pressure and hypertriglyceridemia were more frequent (p < 0.05) in males than in females. An increase in the end-diastolic volume (EDV) and end-systolic volume (ESV) and a decrease in the ejection fraction were noted from CMDS 0 to 3. The EDV and ESV were associated with most cardiometabolic risk factors and strongly correlated with the visceral fat level, waist circumference, and body mass index. We identified a new subgroup as CMDS 3-overly high in patients with CMDS 3 and an excess level of visceral fat. Conclusion When designing strategies for cardiovascular disease prevention in young adults apart from CMDS parameters, bioimpedance analysis should be considered to assess the level of visceral fat, especially in individuals with CMDS 3 because they are at a higher risk of cardiac chamber enlargements. These results can be used to identify new dominants or phenotypes of heart failure with preserved ejection fraction.
Medication Errors among Iranian Intensive Care Nurses: A Systematic Review

Background: Medication Error (ME) is a major patient safety concern in Intensive Care Units (ICUs). Critical care nurses play a crucial role in the safe administration of medication. This study was conducted to comprehensively review the literature concerning the prevalence of ME and associated factors and outcomes in Iranian ICU nurses. Materials and Methods: An extensive search of the literature was carried in international databases including PubMed, Web of Science, Scopus, and Google Scholar, as well as Persian databases such as Magiran and Scientific Information Database (SID) using ME-related keywords and the Persian equivalent of these keywords, from the first article written in this field to artcles published on March 30, 2021. The appraisal tool (AXIS tool) was used to assess the quality of the included studies. Results: Fifteen studies were included in this systematic review. The prevalence of MEs made by ICU nurses was 53.34%. The most common types of MEs were wrong infusion rate (14.12%), unauthorized medication (11.76%), and wrong time (8.49%) errors, respectively. MEs occurred more frequently in morning work shifts (44.44%). MEs happened more frequently for heparin, vancomycin, ranitidine, and amikacin. The most important influential factor in the occurrence of MEs in ICUs was management and human factors. Conclusions: The prevalence of MEs made by Iranian ICU nurses is high. Therefore, nurse managers and policymakers should develop appropriate strategies, including training programs, to reduce the occurrence of MEs made by nurses in ICUs.
Illness Perception, Self-Efficacy, and Medication Adherence in Patients With Coronary Artery Disease: A Path Analysis of Conceptual Model

Introduction Illness perception and self-efficacy in patients with coronary artery disease (CAD) may affect medication adherence, which is one of the most important challenges in disease management in this group of patients. Objective The present study aimed to investigate the factors influencing medication adherence in CAD patients, especially the effect of illness perception and self-efficacy. Methods This study was cross-sectional and conducted from April to September 2021. A total of 259 patients with confirmed CAD were selected by convenience sampling method based on inclusion criteria. Illness perception, self-efficacy, and medication adherence were investigated using Brief IPQ, SCSES, and MARS_10 questionnaires, respectively. The data were analyzed using the STATA software (version 14) and the regression path analysis method. Results Patients had moderate illness perception and high self-efficacy, and 61.8 of them adhered to their medication regimen. Greater illness perception, better self-efficacy, and higher education had a positive effect on medication adherence, and increasing age had a negative effect on it. The final path model shows a good fit of the data in the model (χ2: 0.37, df: 274, χ2/df: 0.36, CFI: 1, IFI: 0.95, TLI: 1.07, and RMSEA: 0.00). Conclusion The results of the present study suggest that patients’ illness perception can play an important role in predicting self-efficacy in disease management and the level of medication adherence in patients with CAD. To improve self-efficacy and medication adherence, future intervention studies should focus on the patient's illness perceptions and their improvement.
CUT-EDGES AND THE INDEPENDENCE NUMBER

The graph theoretic independence number has recently been linked to fullerene stability (2, 4). In particular, Fajtlowicz formed the hy- pothesis - based on conjectures of the program Graffiti - that stable fullerenes tend to minimize their independence numbers. More recently, it was noticed that stable benzenoids do minimize their independence numbers (3, 5, 7, 8). In this paper, we prove a lower bound on the independence number as a func- tion of the number of cut-edges in the graph. Equality holds for this lower bound only for trees with perfect matchings, from which, since chemical trees with perfect matchings are generally more stable than those without, we infer that stable acyclic conjugated hydrocarbons also minimize their independence numbers - analogous to their benzenoid and also perhaps to their fullerene cousins. Together, this evidence suggests that this simple graph invariant may play some significant role in organic chemistry.
Optimizing the dynamic response of the H. B. Robinson nuclear plant using multiobjective particle swarm optimization

Abstract In this paper, the Particle Swarm Optimization (PSO) algorithm is modified to deal with Multiobjective Optimization Problems (MOPs). A mathematical model for predicting the dynamic response of the H. B. Robinson nuclear power plant, which represents an Initial Value Problem (IVP) of Ordinary Differential Equations (ODEs), is solved using Runge-Kutta formula. The resulted data values are represented as a system of nonlinear algebraic equations by interpolation schemes for data fitting. This system of fitted nonlinear algebraic equations represents a nonlinear multiobjective optimization problem. A Multiobjective Particle Swarm Optimizer (MOPSO) which is based on the Pareto optimality concept is developed and applied to maximize the above mentioned problem. Results show that MOPSO efficiently cope with the problem and finds multiple Pareto optimal solutions.
Local Cohomology: An Algebraic Introduction with Geometric Applications

This book provides a careful and detailed algebraic introduction to Grothendieck’s local cohomology theory, and provides many illustrations of applications of the theory in commutative algebra and in the geometry of quasi-affine and quasi-projective varieties. Topics covered include Castelnuovo–Mumford regularity, the Fulton–Hansen connectedness theorem for projective varieties, and connections between local cohomology and both reductions of ideals and sheaf cohomology. It is designed for graduate students who have some experience of basic commutative algebra and homological algebra, and also for experts in commutative algebra and algebraic geometry.
Morita equivalence and symplectic realizations of Poisson manifolds

© Gauthier-Villars (Éditions scientifiques et médicales Elsevier), 1992, tous droits réservés. L’accès aux archives de la revue « Annales scientifiques de l’É. N.S. » (http://www. elsevier.com/locate/ansens) implique l’accord avec les conditions générales d’utilisation (http://www.numdam.org/conditions). Toute utilisation commerciale ou impression systématique est constitutive d’une infraction pénale. Toute copie ou impression de ce fichier doit contenir la présente mention de copyright.
Ruthenium oxide ion selective thin-film electrodes for engine oil acidity monitoring

We demonstrate the concept of a low-cost, rugged, miniaturized ion selective electrode (ISE) comprising a thin film RuO2 on platinum sensing electrode deposited using RF magnetron sputtered in conjunction with an integrated Ag/AgCl and Ag reference electrodes for engine oil acidity monitoring. Model oil samples are produced by adding nitric acid into fresh fully synthetic engine oil and used for sensor evaluation. Experimental results show a linear potential-versus-acid-concentration response for nitric acid concentration between 0 (fresh oil) to 400 ppm, which demonstrate the accuracy of the RuO2 sensor in real-time operation, making it attractive for use in cars and industrial engines.
Dissipative finite degrees of freedom dynamical system and description of optical systems with saturable amplification, saturable losses, and filtering

Description of optical system with saturable amplification, saturable losses and filtering9-10 (see also11-12) is studied. The aim of this work is to derive the system of ode's, that extends the earlier one1-2, including additionally the temporal dependences of the saturated gain and losses. First, this extended system is applied to the case of fast changes in the amplification and losses7-8. Regarding the dissipative solitons, earlier results7-8 have been confirmed. In addition, nonlinear fixed points have been also studied and as result fronts were identified. Next, the extended system is applied to the case of temporal dependent amplification and losses9-10. Linear and nonlinear fixed points of this system have been calculated and their stability identified. Typical solutions discussed earlier9 have been found. Fronts have been also revealed. Phase space interpretation of obtained coherent structures is given.
Multisommabilité des séries entières solutions formelles d’une équation aux $q$-différences linéaire analytique

Nous introduisons une version q-analogue du procede d'acceleration elementaire d'Ecalle-Martinet-Ramis et definissons la notion de serie entiere Gq-multisommable. Nous montrons que toute serie entiere solution formelle d'une equation aux q-differences lineaire analytique est Gq-multisommable.
The finite field restriction problem

This work studies the extension problem for subsets of finite fields. This remains an important unsolved problem in harmonic analysis, in both the Euclidean and finite field setting. We survey the partial results obtained to date, common techniques, and open conjectures. In the case of a homogeneous variety H over a d-dimensional finite field, the L2 → L4 boundedness is proved whenever H contains no hyperplanes. This is accomplished by proving an incidence theorem for cones of this type, and applying a sufficient condition for L2 → L2m obtained by Mockenhaupt and Tao in their 2004 introductory paper. We moreover present counterexamples for particular cones when r < 4, establishing the 2 to 4 bound as optimal in r for general homogeneous varieties.
Gyro Bias On-Orbit Calibration for Micro Satellites

According to gyro application in micro satellites, a new gyro bias real-time on orbit calibration technology is presented and it is independent of any other sensors. The approach relies on gyro on-orbit measurements restricted by satellite attitude dynamics and estimates the gyro bias generated when the gyro is electrified. Observability of the calibration model is analyzed and applicable conditions of the technology are derived. Simulation results indicate that the calibration algorithm is accurate and robust at gyro sampling rate, and its convergence speed is fast. Within the given attitude dynamics model error, the convergence time is less than 100s and the convergence accuracy is about 1.0(o)/h. Calibration performance can meet requirements of spacecraft operations.
Endoscopic screening of the upper gastrointestinal tract for second primary tumors in patients with head and neck cancer in a Western country

Background Patients with head and neck squamous cell carcinoma (HNSCC) can develop second primary tumors (SPTs) in the esophagus. Endoscopic screening could lead to detection of SPTs at early stages and improve survival. Methods We performed a prospective endoscopic screening study in patients with curably treated HNSCC diagnosed between January 2017–July 2021 in a Western country. Screening was performed synchronously (< 6 months) or metachronously (≥ 6 months) after HNSCC diagnosis. Routine imaging for HNSCC consisted of flexible transnasal endoscopy with positron emission tomography/computed tomography or magnetic resonance imaging, depending on primary HNSCC location. The primary outcome was prevalence of SPTs, defined as presence of esophageal high grade dysplasia or squamous cell carcinoma. Results 202 patients (mean age 65 years, 80.7 % male) underwent 250 screening endoscopies. HNSCC was located in the oropharynx (31.9 %), hypopharynx (26.9 %), larynx (22.2 %), and oral cavity (18.5 %). Endoscopic screening was performed within 6 months (34.0 %), 6 months to 1 year (8.0 %), 1–2 years (33.6 %), and 2–5 years (24.4 %) after HNSCC diagnosis. We detected 11 SPTs in 10 patients (5.0 %, 95 %CI 2.4 %–8.9 %) during synchronous (6/85) and metachronous (5/165) screening. Most patients had early stage SPTs (90 %) and were treated with curative intent with endoscopic resection (80 %). No SPTs in screened patients were detected with routine imaging for HNSCC before endoscopic screening. Conclusion In 5 % of patients with HNSCC, an SPT was detected with endoscopic screening. Endoscopic screening should be considered in selected HNSCC patients to detect early stage SPTs, based on highest SPT risk and life expectancy according to HNSCC and comorbidities.
Flexible joint modeling of mean and dispersion for the directional tuning of neuronal spike counts

The study of how the number of spikes in a middle temporal visual area (MT/V5) neuron is tuned to the direction of a visual stimulus has attracted considerable attention over the years, but recent studies suggest that the variability of the number of spikes might also be influenced by the directional stimulus. This entails that Poisson regression models are not adequate for this type of data, as the observations usually present over/underdispersion (or both) with respect to the Poisson distribution. This paper makes use of the double exponential family and presents a flexible model to estimate, jointly, the mean and dispersion functions, accounting for the effect of a circular covariate. The empirical performance of the proposal is explored via simulations and an application to a neurological data set is shown.
How Rational is Popper's Rationality Principle?

This paper shows the relevance of Popper's Rationality Principle (RP) for the appraisal of the impressive mass work emerging, in recent years, in the fields of rationality, learning, evolutionary games and behavioral economic theory. In contradistinction to the well-known rigid criteria of the falsacionist Popper, the RP covers a large and diverse spectrum of behaviors compatible with the minimal idea of 'acting in accordance with the situation'. Its relevance to understand the formation of social conventions or how agents learn 'to play Nash equilibrium' is argued at length here.
Expanders from Markov bases

Diaconis and Sturmfels introduced an influential method to construct Markov chains using commutative algebra. One major point of their method is that infinite families of graphs are simultaneously proved to be connected by a single algebraic calculation. For large state spaces in the infinite families these Markov chains are not rapidly mixing and only ad hoc methods have been available to improve their mixing times. We provide a method to get rapid mixing by constructing expanders for the Diaconis-Sturmfels type Markov chains.
Channel coding: non-asymptotic fundamental limits

Noise is an inalienable property of all communication systems appearing in nature. Such noise acts against the very purpose of communication, that is delivery of a data to the destination with minimal possible distortion. This creates a problem that has been addressed by various disciplines over the past century. In particular, information theory studies the question of the maximum possible rate achievable by an ideal system under certain assumptions regarding the noise generation and structural design constraints. The study of such questions, initiated by Claude Shannon in 1948, has typically been carried out in the asymptotic limit of an infinite number of signaling degrees of freedom (blocklength). Such a regime corresponds to the regime of laws of large numbers, or more generally ergodic limits, in probability theory. However, with the ever increasing demand for ubiquitous access to real time data, such as audio and video streaming for mobile devices, as well as the advent of modern sparse graph codes, one is interested in describing fundamental limits non-asymptotically, i.e. for blocklengths of the order of 1000. Study of these practically motivated questions requires new tools and techniques, which are systematically developed in this work. Knowledge of the behavior of the fundamental limits in the non-asymptotic regime enables the analysis of many related questions, such as the energy efficiency, effects of dynamically varying channel state, assessment of the suboptimality of modern codes, benefits of feedback, etc. As a result it is discovered that in several instances classical (asymptotics-based) conclusions do not hold under this more refined approach.
Diffractaic acid exhibits thioredoxin reductase 1 inhibition in lung cancer A549 cells

Lung cancer is the leading cause of cancer‐related deaths all over the world. Therefore, it has gained importance in the development of new chemotherapeutic strategies to identify anticancer agents with low side effects, reliable, high anticancer potential, and specific to lung cancer cells. Thioredoxin reductase 1 (TrxR1) is an important therapeutic target for lung cancer treatment because of its overexpression in tumor cells. Here, we aimed to examine the anticancer effect of diffractaic acid, a lichen secondary metabolite, in A549 cells by comparing it with the commercial chemotherapeutic drug carboplatin and also to investigate whether the anticancer effect of diffractaic acid occurs via TrxR1‐targeting. The IC50 value of diffractaic acid on A549 cells was determined as 46.37 μg/mL at 48 h, and diffractaic acid had stronger cytotoxicity than carboplatin in A549 cells. qPCR results revealed that diffractaic acid promoted the intrinsic apoptotic pathway through the upregulation of the BAX/BCL2 ratio and P53 gene in A549 cells, which is consistent with the flow cytometry results. Furthermore, migration analysis results indicated that diffractaic acid impressively suppressed the migration of A549 cells. While the enzymatic activity of TrxR1 was inhibited by diffractaic acid in A549 cells, no changes were seen in the quantitative expression levels of gene and protein. These findings provide fundamental data on the anticancer effect of diffractaic acid on A549 cells targeting TrxR1 activity, suggesting that it could be considered a chemotherapeutic agent for lung cancer therapy.
Spectroscopie et imagerie de faibles volumes par RMN : conception et optimisation de capteurs radiofréquence implantables et endoluminaux

L'extraction de spectres de Resonance Magnetique Nucleaire (RMN) d'echantillons de toujours plus faible volume est un veritable defi scientifique. Que cette reduction de volume soit dictee par des difficultes de production du reactif en quantites importantes ou par un souci de miniaturisation du systeme d'analyse, elle conduit a remettre en cause la conception des bobines radiofrequence assurant la reception du signal de RMN. Une problematique similaire se pose pour l'imagerie in vivo par RMN du systeme digestif : les resolutions spatiales necessaires imposent le developpement de capteurs endoluminaux integres sur des catheters. Ainsi apres avoir etudie les sources de signal et de bruit de ces capteurs, nous avons mis en oeuvre des outils de simulation electromagnetique pour optimiser les performances des bobines radiofrequence. Ces simulations ont conduit a la realisation de microbobines solenoidales, planaires ainsi que de capteurs endoluminaux qui ont ete valides en spectroscopie et imagerie par RMN.