Miracle-dz/UniFAR-FTUs huggingface dataset:
mRNA Decapping Factors LSM1 and PAT Paralogs Are Involved in Turnip Mosaic Virus Viral Infection.

Turnip mosaic virus is a devastating potyvirus infecting many economically important brassica crops. In response to this, the plant host engages its RNA silencing machinery, involving AGO proteins, as a prominent strategy to restrain turnip mosaic virus (TuMV) infection. It has also been shown that the mRNA decay components DCP2 and VCS partake in viral infection suppression. Here, we report that the mRNA decapping components LSM1, PAT1, PATH1, and PATH2 are essential for TuMV infection. More specifically, lsm1a/lsm1b double mutants and pat1/path1/path2 triple mutants in summ2 background exhibit resistance to TuMV. Concurrently, we observed that TuMV interferes with the decapping function of LSM1 and PAT proteins as the mRNA-decay target genes UGT87A2 and ASL9 accumulate during TuMV infection. Moreover, as TuMV coat protein can be specifically found in complexes with PAT proteins but not LSM1, this suggests that TuMV "hijacks" decapping components via PAT proteins to support viral infection. [Formula: see text] Copyright © 2022 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license.
Discrimination of electrical tapes using ATR‐FTIR spectroscopy and chemometrics

Electrical tapes are recovered during criminal investigations as physical evidence in cases of rape, kidnapping, and explosion incidents. The analysis of such evidence can provide an evidentiary link between the suspect, the victim, object, or the crime scene. In the present study, 25 brands of electrical tapes have been analyzed using ATR‐FTIR (attenuated total reflectance Fourier transform infrared) spectroscopy. Samples (1 cm2) were analyzed in the mid IR (Infrared) region from 4000–600 cm−1, and the functional groups of various components have been profiled. Chemometric methods‐PCA (principal component analysis) and PCA‐LDA (linear discriminant analysis) have been employed to interpret the data and classify the samples into its respective classes. Preliminary assessment of sample clustering due to similar chemical composition was visualized using PCA. PCA‐LDA applied for classification purpose yielded classification accuracy (calibration) of 92.98% for the adhesive side and 88% for the backing side. The validation results showed classification accuracy of 89.47% for the adhesive side and 84% for the backing side. Blind validation study was carried out using 5 samples, and classification accuracy of 100% and 80% was obtained for the adhesive and the backing side, respectively. In the current study, a preliminary substrate study was carried out, and the results showed that the backing samples could be more accurately matched to their correct source of origin than the adhesive side.
Patients’ Perspectives on Transforming Clinical Trial Participation: Large Online Vignette-based Survey

Background Patients’ participation is crucial to the success of randomized controlled trials (RCTs). However, recruiting and retaining patients in trials remain a challenge. Objective This study aims to describe patients’ preferences for the organization of RCTs (visits on- site or remotely) and evaluate the potential impact of fulfilling preferences on their willingness to participate in a clinical trial. Methods This was a vignette-based survey. Vignettes were case scenarios of real clinical trials assessing pharmacological treatments. These RCTs evaluated 6 prevalent chronic diseases (ie, osteoporosis, osteoarthritis, asthma, cardiovascular diseases, diabetes, and endometriosis). Each vignette described (1) the RCT and characteristics of the treatment tested (ie, doses, administration routes) and (2) the trial procedures and different options (on-site or remotely) for how the trial was organized for informed consent, follow-up visits, and communication of results when the trial was completed. We recruited 628 participants from ComPaRe (www.compare.aphp.fr), a French e-cohort of patients with chronic diseases. The outcomes were the participants’ preferences for the way the trial was organized (on-site or remotely) and their willingness to participate in the trial. Results Of the 628 participants who answered the vignettes, 491 (78.2%) were female (median age 55 years), with different chronic diseases ranging from endometriosis in 59 of 491 (12%) patients to asthma in 133 of 628 (21.2%) patients. In addition, 38 (6.1%) participants wanted to provide informed consent and all trial visits on-site, 176 (28%) wished to participate in the trial entirely remotely, and 414 (65.9%) wanted to combine remote-based and hospital-based visits. Considering the trial as a whole, when the trial was organized in a way that the patients preferred, the median (Q1-Q3) likelihood of participation in the trial was 90% (80-100) versus 60% (30-80) if the trial followed the patients’ nonpreferred model. Furthermore, 256 (40.8%) patients responded to open-ended questions expressing their experience with trial participation and visits to the hospital and providing suggestions for improvement. The patients emphasized the need to personalize the way a trial is organized according to each patient’s needs and conditions. Conclusions There was a significant diversity in the participants’ preferences. Most participants preferred hybrid organization involving both on-site and remote visits. Participants were more likely to participate in a trial organized according to their preferences.
Identifying small for gestational age preterm infants from the Finnish Medical Birth Register using eight growth charts

deliveries for early onset FGR at these gestations. We also observed differences between national and international charts, as Fenton and the intergrowth charts provided lower SGA proportions than the Nordic charts. This suggests that the international charts may not accurately describe Finnish birthweight distributions. Other studies have also shown that Intergrowth charts underestimated SGA in Nordic countries. 5 These results highlight the importance of choosing the right chart when quantifying FGR in preterm births, and suggest that using the 10 th percentile threshold with international or birthweight charts may underestimate how many children risk adverse outcomes due to growth impairment, in particular those born at 28-32 weeks of GA. Using different charts also makes it difficult to compare research findings. The charts used in FGR research should be detailed in papers, so that meta-analyses can assess any impact on their findings. More prospective studies on neonatal and long-term outcomes are needed to provide evidence on the best charts to use. These should include the threshold for monitoring FGR in children born preterm
The Effect of Robot-Mediated Virtual Reality Gaming on Upper Limb Spasticity Poststroke: A Randomized-Controlled Trial.

Objective: Stroke is a common reason for motor disability and is often associated with spasticity and poor motor function of the upper limbs involved. Spasticity management is important to accelerate motor recovery. The objective of this study was to investigate the effects of training with robot-mediated virtual reality gaming on upper limb spasticity and motor functions in individuals with chronic stroke. Materials and Methods: A total of 40 Saudi individuals with chronic stroke were involved in this study. Participants were randomly assigned to two groups. The experimental group received conventional physiotherapy and training with robot-mediated virtual reality gaming, and the control group received only conventional physiotherapy. Outcomes were measured by the Action Research Arm Test (ARAT), Wolf Motor Function Test (WMFT), WMFT-Time, Modified Ashworth Scale (MAS), Active Range of Motion (AROM) of multiple joints of the upper limb, and Handgrip Strength (HGS). The scores of all the outcome measures were recorded at baseline and after the completion of the treatment. Results: Individuals with stroke in the experimental group had a better improvement in most measured variables (AROM of shoulder abduction, elbow supination and wrist extension, WMFT-Time, HGS, ARAT, WMFT, and MAS) compared with the control group after the completion of the treatment. Both groups showed significant improvement in all the measured variables after completion of the treatment, except in MAS for wrist flexors in the control group. Conclusion: Training with robot-mediated virtual reality gaming was effective in modulating spasticity and improving the motor functions of the affected upper limbs in individuals with chronic stroke. This study was registered in ClinicalTrial.gov (NCT05069480).
Hydroclimatic adaptation critical to the resilience of tropical forests

Forest and savanna ecosystems naturally exist as alternative stable states. The maximum capacity of these ecosystems to absorb perturbations without transitioning to the other alternative stable state is referred to as ‘resilience’. Previous studies have determined the resilience of terrestrial ecosystems to hydroclimatic changes predominantly based on space‐for‐time substitution. This substitution assumes that the contemporary spatial frequency distribution of ecosystems’ tree cover structure holds across time. However, this assumption is problematic since ecosystem adaptation over time is ignored. Here we empirically study tropical forests’ stability and hydroclimatic adaptation dynamics by examining remotely sensed tree cover change (ΔTC; aboveground ecosystem structural change) and root zone storage capacity (Sr; buffer capacity towards water‐stress) over the last two decades. We find that ecosystems at high (>75%) and low (<10%) tree cover adapt by instigating considerable subsoil investment, and therefore experience limited ΔTC—signifying stability. In contrast, unstable ecosystems at intermediate (30%–60%) tree cover are unable to exploit the same level of adaptation as stable ecosystems, thus showing considerable ΔTC. Ignoring this adaptive mechanism can underestimate the resilience of the forest ecosystems, which we find is largely underestimated in the case of the Congo rainforests. The results from this study emphasise the importance of the ecosystem's temporal dynamics and adaptation in inferring and assessing the risk of forest‐savannah transitions under rapid hydroclimatic change.
Customer relationship management to improve the performance of insurance sector in India

In this work we studied different aspects of Customer relationship management for improvement of the performance of Insurance sectors. We identified some factors which may prohibit the improvement. On the basis of literature review Lean relationship management has been identified. An assessment has been done to find out the base line performance level regarding Lean Customer relationship management in the insurance sectors.
Temporal dynamics of mental imagery, craving and consumption of craved foods: an experience sampling study

Abstract Objective: According to the elaborated intrusion theory of desire, an initial thought about a wanted substance is elaborated with mental imagery, which increases craving and the probability of consuming the substance. We used an app-assisted experience sampling approach to test this theory in the context of food craving and eating.Design: Overall, 221 females (mean age = 21 years; mean body mass index = 22) reported craving, mental imagery, and food consumption six times per day (2 h intervals) for seven consecutive days. Additionally, two traits (general food craving and imagery ability) were assessed.Main outcome measures: craving intensity, food consumption.Results: The probability of eating a craved food increased if the vividness of the mental food image and craving intensity increased two hours before – independent of trait food craving and trait imagery ability. We also found evidence of controlled eating behavior, with participants consuming the food they craved in only 38% of the cases.Conclusion: Mental imagery vividness and craving intensity predict consumption of craved food. The association between craving and eating might be stronger in individuals who struggle with controlling their eating behavior. Therefore, future studies should examine these relationships in overweight/obese samples or patients with eating disorders.
Catalytic role of formaldehyde in particulate matter formation

Significance Particulate matter, often formed via cloud processing, strongly influences the Earth’s climate and air quality. Particle composition depends on anthropogenic and biogenic emissions. Thus, in order to understand climate change, knowledge of the difference between preindustrial and current conditions is critical. Under preindustrial conditions, multifunctional organic hydroperoxides, which are strong oxidants and have the ability to contribute to particulate matter formation, are in higher concentrations in the atmosphere. In this work, we focus on the previously unknown importance of hydroxymethyl hydroperoxide, which can be formed by gas-phase reactions and in-cloud reaction of hydrogen peroxide with the simplest aldehyde, formaldehyde, revealing the catalytic role of formaldehyde, and demonstrate that this chemistry is of great importance for particle formation. Formaldehyde (HCHO), the simplest and most abundant carbonyl in the atmosphere, contributes to particulate matter (PM) formation via two in-cloud processing pathways. First, in a catalytic pathway, HCHO reacts with hydrogen peroxide (H2O2) to form hydroxymethyl hydroperoxide (HMHP), which rapidly oxidizes dissolved sulfur dioxide (SO2,aq) to sulfate, regenerating HCHO. Second, HCHO reacts with dissolved SO2,aq to form hydroxymethanesulfonate (HMS), which upon oxidation with the hydroxyl radical (OH) forms sulfate and also reforms HCHO. Chemical transport model simulations using rate coefficients from laboratory studies of the reaction rate of HMHP with SO2,aq show that the HMHP pathways reduce the SO2 lifetime by up to a factor of 2 and contribute up to ∼18% of global sulfate. This contribution rises to >50% in isoprene-dominated regions such as the Amazon. Combined with recent results on HMS, this work demonstrates that the one-carbon molecules HMHP and HCHO contribute significantly to global PM, with HCHO playing a crucial catalytic role.
Conjoint measurement of perceived transparency and perceived contrast in variegated checkerboards

Abstract One fundamental question in vision research is how the retinal input is segmented into perceptually relevant variables. A striking example of this segmentation process is transparency perception, in which luminance information in one location contributes to two perceptual variables: the properties of the transparent medium itself and of what is being seen in the background. Previous work by Robilotto et al. (2002, 2004) suggested that perceived transparency is closely related to perceived contrast, but how these two relate to retinal luminance has not been established. Here we studied the relationship between perceived transparency, perceived contrast, and image luminance using maximum likelihood conjoint measurement (MLCM). Stimuli were rendered images of variegated checkerboards that were composed of multiple reflectances and partially covered by a transparent overlay. We systematically varied the transmittance and reflectance of the transparent medium and measured perceptual scales of perceived transparency. We also measured scales of perceived contrast using cut-outs of the transparency stimuli that did not contain any geometrical cues to transparency. Perceptual scales for perceived transparency and contrast followed a remarkably similar pattern across observers. We tested the empirically observed scales against predictions from various contrast metrics and found that perceived transparency and perceived contrast were equally well predicted by a metric based on the logarithm of Michelson or Whittle contrast. We conclude that judgments of perceived transparency and perceived contrast are likely to be supported by a common mechanism, which can be computationally captured as a logarithmic contrast.
EVALUATING THE COOLING RATE OF HOT MIX ASPHALT IN TROPICAL CLIMATE

This paper aims to investigate the environmental effect on cooling rate and to determine the appropriate time available for compaction (TAC) using laboratory tests. This includes the study parameters, namely solar flux, base and ambient temperatures (daytime and night-time paving) and wind velocity, focusing on hot mix asphalt (HMA) asphalt concrete wearing with 14 mm nominal maximum aggregate size (ACW14) mix type for the wearing course and ACB28 mix type for the binder course. Samples were prepared in slab moulds 30.5 cm × 30.5 cm × 5 cm and compacted using a manually operated steel-roller. Readings were taken by averaging the temperature measurements at the middle and surface of the slabs and a temperature of 160 oC was used as the mixing temperature. A control sample was prepared for each mix type and tested in the laboratory without the influence of wind velocity and solar flux. It was found that the cooling rate of HMA is significantly affected by environmental factors, thus influencing the TAC. The TAC tends to decrease by 15-50% during windy and night conditions but increases by up to 100% during daytime conditions compared to the control samples.
Polymeric nanoparticles for the treatment of prostate cancer - technological prospecting and critical analysis.

BACKGROUND Polymeric nanoparticles have a wide diversity, and due to their toxicity and biodegradability they have been widely used in the health area. Its use allows stability of some compounds, targeted delivery, and increased half-life, in this context, making some treatment proposals more effective. Prostate cancer, in turn, is among the types of cancer with the highest mortality, and the lack of effective treatment causes several strategies to meet this need. OBJECTIVE The objective of this work was to verify patents that use polymeric nanoparticles for the treatment of prostate cancer. METHODS For that, specific keywords to direct the search were applied in Patent Scope. After obtaining the patents, one was selected for the development of critical analysis in relation to its chemistry and biology. RESULTS A total of five patents were found and, of these, an invention that used PCL-PLGA-PEG-COOH polymeric nanoparticles with two natural compounds, resveratrol and celastrol, providing an alternative method to traditional monotherapies. CONCLUSION The prospective analysis serves to direct us in relation to the technologies currently used in certain fields. Based on several cases of cancer and specifically the countless cases of prostate cancer, five recent patents were found using polymeric nanoparticles. However, only one brought a different aspect of all the treatments used lately. It brought an invention containing two natural compounds being carried with polymeric nanoparticles with promising results.
MACS-DGC versus DGC Sperm Wash Procedure:Comparing Clinical Outcomes in Couples with Male Factor Infertility Undergoing ICSI: A Clinical Trial Study

Background Implementation of sperm preparation techniques based on cellular and molecular characteristics can improve the clinical outcomes of couples with male factor infertility. These methods attempt to select better sperm compared to classical methods of preparation such as swim-up and density gradient centrifugation (DGC). In this view, the aim of this study was the comparison of clinical outcomes of magnetic-activated cell separation (MACS) followed by DGC or DGC alone in infertile men undergoing intracytoplasmic sperm injection (ICSI). Materials and Methods For this prospective single parallel blind clinical trial study, 206 infertile couples with male factor infertility and having abnormal sperm morphology higher than 96% were included. 106 and 100 couples were considered for the study (MACS-DGC) and control group (DGC), respectively. Clinical outcomes of ICSI; fertilization, embryo quality, and implantation, pregnancy rates were compared between two groups. Materials and Methods For this prospective single parallel blind clinical trial study, 206 infertile couples with male factor infertility and having abnormal sperm morphology higher than 96% were included. 106 and 100 couples were considered for the study (MACS-DGC) and control group (DGC), respectively. Clinical outcomes of ICSI; fertilization, embryo quality, and implantation, pregnancy rates were compared between two groups. Results Mean of fertilization (80.19 ± 1.88 vs. 75.63 ± 2.06, P=0.1), top embryo quality on the day 3 (30.22 ± 3.59 vs. 17.96 ± 2.9, P=0.009), clinical pregnancy (30.76% vs. 22.22%, P=0.19), and implantation rate (18.12% vs. 10.42%, P=0.04) were higher in the study group compared to the control group. Conclusion Sperm preparation by MACS followed by DGC in teratozoospermic men could improve the clinical outcomes after ICSI (Registration number: IRCT201610317223N8).
The burden of illness of rheumatoid arthritis in Latin America—A systematic literature review

Rheumatoid arthritis (RA) is a chronic autoimmune disease which, when left untreated, may result in the destruction of multiple joints and damage a wide variety of body systems, including the skin, eyes, lungs, heart, and blood vessels. The objective of this study was to conduct a systematic review of disease burden for RA in Argentina, Brazil, Colombia, Mexico, and Venezuela. PubMed/Medline, Embase, and Web of Science were searched for publications in English, Spanish, or Portuguese from 2008 through June 2018. A total of 1700 records were retrieved and 36 articles were included. The estimated prevalence of RA for these countries ranged from 0.15% (Colombia) to 2.8% (Mexico). The Global Burden of Disease initiative 2019 estimated that RA accounted for 0.13% of world disability‐adjusted life‐years. For Latin America, these figures were higher: Argentina 0.16%, Brazil 0.16%, Colombia 0.21%, Mexico 0.30%, and Venezuela 0.24%. RA has a negative impact on physical, mental, and emotional well‐being as shown by substantially lower scores on measures of quality of life (SF‐36) compared with the general population. The annual direct cost in Mexico was estimated at US$3599 per person. For patients with severe RA in Brazil these costs were approximately US$10 000. Data from other studied countries were similar. Though evidence of the full cost and impact of RA in Latin American countries is scarce and additional studies are needed, the burden of RA in these regions is significant and comparable to other parts the world.
The performance of GSM 900 antennas in the presence of people and phantoms

The antenna efficiency and mean effective gain (MEG) of several commercial (predominantly dual band) mobile phones are evaluated over the GSM 900 frequency range. Measurements are performed both statistically, in the presence of people, and with phantom heads and hands. Particular attention is given to the different loss terms involved, such as mismatch and spatial filtering, and to the relative contributions to loss of different parts of the body. The method used is that of 3D radiation pattern integration based on fast spherical near field measurements around the combination of the user and phone. Helical, "flip" and planar inverted-F antenna (PIFA) designs are evaluated. Results show that reasonable convergence is achieved with approximately 15 users. The average efficiency is in the 3-8% range for all phones when used next to the head. Measurements away from the head show that much of the efficiency reduction is due to loss in the hand - phantom measurements confirm this. The loss mechanisms at GSM 900 are compared to those previously reported at 1800 MHz.