Miracle-dz/UniFAR-FTUs huggingface dataset:
Análise do papel das GitHub Discussions no ambiente de desenvolvimento de Software Livre

GitHub Discussions é uma nova funcionalidade do GitHub que possibilita a abertura de discussões, e perguntas e respostas, fora do ambiente das pull requests e issues. Dada a novidade desta funcionalidade, é importante entender o papel que ela desempenha na entrada de novatos e sustentabilidade de projetos no GitHub. Assim, o objetivo deste trabalho é analisar a relação das GitHub Discussions com as issues e pull requests e investigar como as discussões podem impulsionar a entrada de novos contribuidores. Em análises preliminares com o projeto Vercel/next.js, nota-se que um grande número de usuários teve sua primeira interação no projeto por meio das GitHub Discussions e que uma pequena parcela se envolveu em issues e pull requests. Como consolidação deste trabalho, novos projetos serão analisados e novas análises serão realizadas a fim de ter uma melhor compreensão do papel das GitHub Discussions no ecossistema do GitHub.
Meeting The Standards In Using Ict For Secondary Teaching A Guide To The Itt Nc

Thank you very much for downloading meeting the standards in using ict for secondary teaching a guide to the itt nc. Maybe you have knowledge that, people have search numerous times for their favorite novels like this meeting the standards in using ict for secondary teaching a guide to the itt nc, but end up in malicious downloads. Rather than reading a good book with a cup of coffee in the afternoon, instead they cope with some harmful virus inside their computer.
Buildings That Teach: A Strategy For Sustainable Design

This paper discusses the engagement of groups from tertiary education and the building industry in the refurbishment of an existing log cabin on a university campus to function as a demonstration sustainable project. The paper describes the development of an interpretive and qualitative research model to uncover the complex factors behind behavioural influences. The research is a case study of creating, monitoring, and using a sustainable building, including a series of pre and post engagement interviews with those involved in the building, used to analyse why participants become engaged in the project, and as a consequence how their behaviour might change towards sustainability. Initial findings suggest ‘action’ is a significant moment where behaviour changes, as it creates a medium for learning new behaviour and abandoning the old. In this project action only increased as the project gained momentum. When the building was almost half finished people began to volunteer to be involved with it. The acceptance ‘tipping point’ or threshold came when there was enough physical reality that people could see becoming involved would produce something tangible. The results so far suggest that changing to sustainability stems from the initial involvement of a few highly motivated individuals but when there is sufficient physical reality and reduced psychological distance, more people become involved.
Wild Plants of Central Kazakhstan with Antibiotic Properties and Effect

This article presents the results of field studies of the biological diversity of wild plants with antibiotic properties growing in the climatic conditions of Central Kazakhstan. As a result of the field studies, 28 plant species with antibiotic properties belonging to 26 families were found. Among them, the most numerous are from Asteraceae family – 8 species and the Lamiaceae family – 6 species. The rest of the plant species were distributed according to the principle “one species - one family”. These plants have enormous potential for health, but mainly grow locally or are scattered in small groups and do not form thickets of commercial value in nature. We also conducted a survey among two age groups – 18 to 25 years old and 35 to 55 years old. The survey showed that the older generation is more aware of plant species with antibiotic properties and is more willing to choose natural herbs. The second group knows only those types of plants that are part of the famous syrups and lozenges for colds. Based on the above data, it can be concluded that a sufficient number of plants with antibiotic properties grow in the territory of Central Kazakhstan. Given their low cost and availability, we believe that they need to be popularized among the younger generation and recommended for commercial use. © 2022 Friends Science Publishers
Diaphragmatic Movement at Rest and After Exertion: A Non-Invasive and Easy to Obtain Prognostic Marker in COPD

Introduction Diaphragmatic dysfunction is common in patients with chronic obstructive pulmonary disease (COPD). This study aimed to assess the prognostic significance of impaired diaphragmatic movement at rest and after exercise. Methods This was a prospective study of patients with stable COPD. Diaphragmatic movements were examined at rest and after a 6-minute walking test (6MWT) with a convex transducer with a frequency of 3.5-5-7.5 MHz. Maximal movement of the diaphragm was measured in both right and left diaphragm, and the side with higher amplitude was selected for further analysis. Measurements obtained were evaluated for their prognostic value for a composite endpoint of moderate and severe COPD exacerbations and death in 1 year time period was assessed. In addition, postbronchodilator spirometry, symptoms, quality of life, and demographic and clinical information were collected. Results A total of 96 patients were analyzed (62.5% male, mean age 65.1 years (standard deviation (SD): 8.1), mean FEV1 (% predicted): 55.8%, SD: 18.3%, mean CAT: 15.6 units, SD: 9.2). Sixty-four patients (67%) presented the composite endpoint. In the multivariate Cox analysis, FVC (HR = 0.944, p = 0.005), CAT score (HR = 1.133, p = 0.011), previous severe exacerbations (HR = 5.446, p = 0.004) and diaphragmatic movement at rest (HR = 0.932, p = 0.033) were found to be predictors of the composite endpoint. This model correctly classified 86.5% (83/96) of the patients. Conclusion Non-invasive assessment of diaphragmatic movement by ultrasound measurement both at rest and after exercise could contribute to the assessment of disease severity and prognosis of COPD.
A survey of the state of the practice for research software in the United States

Research software is a critical component of contemporary scholarship. Yet, most research software is developed and managed in ways that are at odds with its long-term sustainability. This paper presents findings from a survey of 1,149 researchers, primarily from the United States, about sustainability challenges they face in developing and using research software. Some of our key findings include a repeated need for more opportunities and time for developers of research software to receive training. These training needs cross the software lifecycle and various types of tools. We also identified the recurring need for better models of funding research software and for providing credit to those who develop the software so they can advance in their careers. The results of this survey will help inform future infrastructure and service support for software developers and users, as well as national research policy aimed at increasing the sustainability of research software.
Optimal charging plan for electric bus considering time-of-day electricity tariff

Purpose The purpose of this study is to develop an optimization method for charging plans with the implementation of time-of-day (TOD) electricity tariff, to reduce electricity bill. Design/methodology/approach Two optimization models for charging plans respectively with fixed and stochastic trip travel times are developed, to minimize the electricity costs of daily operation of an electric bus. The charging time is taken as the optimization variable. The TOD electricity tariff is considered, and the energy consumption model is developed based on real operation data. An optimal charging plan provides charging times at bus idle times in operation hours during the whole day (charging time is 0 if the bus is not get charged at idle time) which ensure the regular operation of every trip served by this bus. Findings The electricity costs of the bus route can be reduced by applying the optimal charging plans. Originality/value This paper produces a viable option for transit agencies to reduce their operation costs.
Predicting and Avoiding SLA Violations of Containerized Applications using Machine Learning and Elasticity

: Container-based virtualization represents a low-overhead and easy-to-manage alternative to virtual machines. On the other hand, containers are more prone to performance interference and unpredictability. Consequently, there is growing interest in predicting and avoiding performance issues in containerized environments. Existing solutions tackle this challenge through proactive elasticity mechanisms based on workload variation predictions. Although this approach may yield satisfactory results in some scenarios, external factors such as resource contention can cause performance losses regardless of workload variations. This paper presents Flavor, a machine-learning-based system for predicting and avoiding performance issues in containerized applications. Rather than relying on workload variation prediction as existing approaches, Flavor predicts application-level metrics (e.g., query latency and throughput) through a deep neural network implemented using Tensorﬂow and scales applications accordingly. We evaluate Flavor by comparing it against a state-of-the-art resource scaling approach that relies solely on workload prediction. Our results show that Flavor can predict performance deviations effectively while assisting operators to wisely scale their services by increasing/decreasing the number of application containers to avoid performance issues and resource underutilization.
Packaging as a Brand Builder

Over the past decades, consumers have spent no more than one-minute scanning for making buying decisions on the products they need. Hence, the marketplace has been a growing emphasizing towards packaging. It has been identified that packaging plays a vital role in effect consumer buying behaviour. From this view, the packaging is no longer considered only as of the container for a product. Marketplace believed that packaging is one of the expressive packaging to gain consumer attention and become an ultimate selling preposition stimulating consumer buying behaviour. This paper discussed the packaging as a brand builder to stimulate consumer buying behaviour to purchase a particular brand.
Privacy - Preserving Public Auditing for Regenerating - Code - Based Cloud Storage

Data integrity maintena nce is the major objective in cloud storage. It includes audition using TPA for unauthorized access. This work implements protecting the data and regeneration of data if someone mishandles it. This job will be assigned to a Proxy server. The data of the us ers will be stored in public and private area of the cloud. So that only public cloud data will be accessed by user and private cloud will remain more secured. Once any unauthorized modification is made, the original data in the private cloud will be retri eved by the Proxy server and will be returned to the user. Every data stored in the cloud will be generated with a Hash value using Merkle Hash Tree technique. So modification in content will make changes in the Hash value of the document as well. Proxy al so perform signature delegation work by generating private and public key for every user using OEAP Algorithm so that the security will be maintained. In our proposed we implement this scenario in a multi owner environment in which one document will be acc ess by user groups. In this context, the access limit should be properly maintained so that no user for other group should be allowed to modify a particular group's data. Also, if any modifications made in that data, it will be informed to the user as well by the proxy.
Genome-Wide Identification and Transcriptional Expression Profiles of PP2C in the Barley (Hordeum vulgare L.) Pan-Genome

The gene family protein phosphatase 2C (PP2C) is related to developmental processes and stress responses in plants. Barley (Hordeum vulgare L.) is a popular cereal crop that is primarily utilized for human consumption and nutrition. However, there is little knowledge regarding the PP2C gene family in barley. In this study, a total of 1635 PP2C genes were identified in 20 barley pan-genome accessions. Then, chromosome localization, physical and chemical feature predictions and subcellular localization were systematically analyzed. One wild barley accession (B1K-04-12) and one cultivated barley (Morex) were chosen as representatives to further analyze and compare the differences in HvPP2Cs between wild and cultivated barley. Phylogenetic analysis showed that these HvPP2Cs were divided into 12 subgroups. Additionally, gene structure, conserved domain and motif, gene duplication event detection, interaction networks and gene expression profiles were analyzed in accessions Morex and B1K-04-12. In addition, qRT-PCR experiments in Morex indicated that seven HvMorexPP2C genes were involved in the response to aluminum and low pH stresses. Finally, a series of positively selected homologous genes were identified between wild accession B1K-04-12 and another 14 cultivated materials, indicating that these genes are important during barley domestication. This work provides a global overview of the putative physiological and biological functions of PP2C genes in barley. We provide a broad framework for understanding the domestication- and evolutionary-induced changes in PP2C genes between wild and cultivated barley.
The Effect of Humic Acid and Nano-Chelate Iron on the Absorption of Some Nutrients, Grain Yield, Oil, and Essential Oil of (Nigella sativa) under Drought Stress

ABSTRACT To examine the effect of humic acid and nano-chelate iron on the absorption of some nutrients and oil content and essential oil of (Nigella sativa) under two-year experimental drought stress (2018-and 2019-) in Agricultural and Natural Resources Research Station of Eqlid city, an experiment was conducted as a split factorial design in the form of a randomized complete block design with three replications. The main plots included irrigation at three levels (50, 75, and 100% of available water), sub-factors including humic acid at three levels (0, 250, and 500 mg/l), and nano-chelate iron at three levels (0, 1, and 2 g/l). The results revealed that drought stress decreased nutrient absorption and the amount of essential oil and oil content. Applying humic acid and nano-chelate iron decreased the effects of stress so that the application of humic acid and nano-chelate iron increased the yield by 21 and 27% compared to the control treatment. Interaction of humic acid, nano-chelate iron showed that the highest grain yield (1036) kg/ha) was observed in 500 mg/l of humic acid and 2 g/l of nano-chelate iron with 75% of available water. In general, it can be concluded that the use of humic acid and nano-chelate iron in conditions of water scarcity caused more absorption of nutrients, increased grain yield, and moderated the effects of drought stress compared to the control.
A novel wheel-track hybrid electric powered wheelchair for stairs climbing

Aiming at efficient locomotion on the ground and safe stairs climbing for aged or physical disabled people, a wheel-track hybrid electric powered wheelchair (EPW) is designed, analyzed, and demonstrated extensively on various conditions. We first present the wheel-track hybrid design of the EPW with a focus on the mechanical structure and of onboard control system. We then discuss and analyze the wheel and the track mobile modes and their switching design of the EPW. The use of the track mobile mode is primarily for climbing up and down the stairs while the wheel mobile mode is for commonly ground surfaces. The mechanics analysis during these two mode switching and in the process of climbing up and down the stairs are also presented in the paper. The simulation and experimental results show that the new wheel-track hybrid EPW can effectively conduct the two locomotion modes including climbing up and down the stairs. The results also validate the motion mechanics calculation models and the dynamic mode switching between two mobile modes.
Mycotoxin Exposure in Children through Breakfast Cereal Consumption in Chile

Mycotoxins are unavoidable contaminants produced by fungi in food, especially grains. This study aimed to measure the occurrence and levels of total aflatoxins (AFs); ochratoxin A (OTA); zearalenone (ZEN); fumonisins B1, B2, and B3 (FUM); deoxynivalenol (DON); and T-2/HT-2 toxins in the four most commonly consumed breakfast cereals in Chile and to assess mycotoxin exposure and risk in children aged 2 to 13 years due to cereal consumption. In this study, a total of 110 batches with three subsamples of the four brands were sampled in supermarkets from November 2019 to June 2021. Samples were analyzed by Veratox® ELISA (Neogen). Exposure was assessed by estimated daily intake (EDI) considering the levels found in a modified lower bound (mLB) and upper bound (UB). Risk was estimated by margin of exposure (MOE) in the case of OTA and AFs and hazard quotient (HQ) for the rest of the mycotoxins. No T2/HT2 toxins were detected. Few samples had quantifiable levels of ZEN, FUM, and DON except for brand 1, with a mean (standard deviation, SD) of 54 (20), 1552 (351), and 706 (218) ng/g, respectively. In addition, three FUM samples and one DON sample had values over the Chilean regulation. Brands 2, 3, and 4 had quantifiable levels of AFs, with mean (SD) values of 1.3 (0.1), 2.1 (0.6), and 1.9 (0.4) ng/g, respectively. Brand 3 had quantifiable levels of OTA, with a mean (SD) of 2.3 (0.4) ng/g. Estimated exposure indicated a risk of AFs in all scenarios, and of FUM for brand 1 consumption, OTA and DON for brand 3 consumption, and OTA for brand 4 consumption in the mLB worst-case scenario. In general, mycotoxin levels were below the Chilean regulatory limits, but most of them were above the EU regulation for processed cereal-based food in young children. Because the risk was higher in the 2- to 5-year-old children, we recommend special regulations for this group in Chile.
Antigen Cross-Presentation by Murine Proximal Tubular Epithelial Cells Induces Cytotoxic and Inflammatory CD8+ T Cells

Immune-mediated glomerular diseases are characterized by infiltration of T cells, which accumulate in the periglomerular space and tubulointerstitium in close contact to proximal and distal tubuli. Recent studies described proximal tubular epithelial cells (PTECs) as renal non-professional antigen-presenting cells that stimulate CD4+ T-cell activation. Whether PTECs have the potential to induce activation of CD8+ T cells is less clear. In this study, we aimed to investigate the capacity of PTECs for antigen cross-presentation thereby modulating CD8+ T-cell responses. We showed that PTECs expressed proteins associated with cross-presentation, internalized soluble antigen via mannose receptor-mediated endocytosis, and generated antigenic peptides by proteasomal degradation. PTECs induced an antigen-dependent CD8+ T-cell activation in the presence of soluble antigen in vitro. PTEC-activated CD8+ T cells expressed granzyme B, and exerted a cytotoxic function by killing target cells. In murine lupus nephritis, CD8+ T cells localized in close contact to proximal tubuli. We determined enhanced apoptosis in tubular cells and particularly PTECs up-regulated expression of cleaved caspase-3. Interestingly, induction of apoptosis in the inflamed kidney was reduced in the absence of CD8+ T cells. Thus, PTECs have the capacity for antigen cross-presentation thereby inducing cytotoxic CD8+ T cells in vitro, which may contribute to the pathology of immune-mediated glomerulonephritis.
An Early Disturbance in Serotonergic Neurotransmission Contributes to the Onset of Parkinsonian Phenotypes in Drosophila melanogaster

Parkinson’s disease (PD) is a neurodegenerative disease characterized by motor symptoms and dopaminergic cell loss. A pre-symptomatic phase characterized by non-motor symptoms precedes the onset of motor alterations. Two recent PET studies in human carriers of mutations associated with familial PD demonstrate an early serotonergic commitment—alteration in SERT binding—before any dopaminergic or motor dysfunction, that is, at putative PD pre-symptomatic stages. These findings support the hypothesis that early alterations in the serotonergic system could contribute to the progression of PD, an idea difficult to be tested in humans. Here, we study some components of the serotonergic system during the pre-symptomatic phase in a well-characterized Drosophila PD model, Pink1B9 mutant flies. We detected lower brain serotonin content in Pink1B9 flies, accompanied by reduced activity of SERT before the onset of motor dysfunctions. We also explored the consequences of a brief early manipulation of the serotonergic system in the development of motor symptoms later in aged animals. Feeding young Pink1B9 flies with fluoxetine, a SERT blocker, prevents the loss of dopaminergic neurons and ameliorates motor impairment observed in aged mutant flies. Surprisingly, the same pharmacological manipulation in young control flies results in aged animals exhibiting a PD-like phenotype. Our findings support that an early dysfunction in the serotonergic system precedes and contributes to the onset of the Parkinsonian phenotype in Drosophila.
IRS-Assisted Physical Layer Network Coding Over Two-Way Relay Fading Channels

This article investigates the performance of intelligent reflective surfaces (IRS)-aided physical layer network coding (PNC) in two-way relaying channels (TWRC). Specifically, IRS is used to eliminate carrier phase offset (CPO) at the relay node. To this end, the IRS reflectors’ phase shifts are optimized to align the received signals from two source nodes at the relay. This facilitates using a simple mapping function at the relay to map the superimposed signal to a network-coded signal. Two scenarios are considered, the first of which assumes that each source node is served by a separate IRS panel, while the second scenario considers the more challenging case where only one IRS panel is available for the two source nodes. In the latter case, the IRS panel is seen by both source nodes and its phase shifts are optimized to mitigate the CPO problem while maximizing the received signal amplitude at the relay. This optimization problem is formulated and solved over the complex circle manifold. Finally, we extend the IRS-assisted PNC system to include channel coding and higher modulation orders, for which a repeat accumulate (RA) channel-coded IRS-aided PNC scheme is proposed for general quadrature amplitude modulation (QAM) signals. A belief propagation (BP) based algorithm is designed to decode the network-coded sequences over a q-Ring using modular arithmetic. Our simulation results validate the theoretical error expressions derived for the two-IRS scenario as well as the efficacy of the proposed manifold optimization approach for the one-IRS scenario. The results also confirm the efficacy of the designed channel-coded IRS-aided PNC using high QAM modulation orders.