Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer

Vitamin D has been associated with risk, development, and progression of cancer. However, the genes involved in its metabolism are highly polymorphic, compromising its activity. The aim of this study is to evaluate the association between the gene polymorphisms involved in the metabolic pathway of vitamin D and survival in patients with non-small-cell lung cancer (NSCLC). The study was designed as an observational cohort which included 194 Caucasians patients from southern Spain with NSCLC. Real-time polymerase chain reaction was used to analyze the following polymorphisms: CYP27B1 rs4646536, rs3782130, and rs10877012; CYP24A1 rs6068816 and rs4809957; GC rs7041; CYP2R1 rs10741657; VDR rs1544410 (BsmI), rs11568820 (Cdx-2), rs2228570 (FokI), rs7975232 (ApaI), and rs731236 (TaqI). Progression-free survival (PFS) and overall survival were assessed. Cox regression showed that rs4646536 was associated with PFS in the general population (p = 0.0233) and in the non-resected NSCLC subgroup (p = 0.0233). In the resected NSCLC subgroup, rs11568820 was associated with OS (p = 0.0129) and rs7041 with PFS (p = 0.0447). In the non-resected NSCLC subgroup, rs6068816 was associated with PFS (p = 0.0048) and OS (p = 0.0089) and rs731236 and rs7975232 were associated with OS (p = 0.0005) and PFS (p = 0.0002), respectively. The other polymorphisms showed no effect on the results. The rs4646536, rs6068816, rs7041, rs11568820, rs731236, and rs7975232 polymorphisms are associated with survival in NSCLC and may have a substantial role as prognostic markers of the disease.
New Developments in Social Network Analysis

This review of social network analysis focuses on identifying recent trends in interpersonal social networks research in organizations, and generating new research directions, with an emphasis on conceptual foundations. It is organized around two broad social network topics: structural holes and brokerage and the nature of ties. New research directions include adding affect, behavior, and cognition to the traditional structural analysis of social networks, adopting an alter-centric perspective including a relational approach to ego and alters, moving beyond the triad in structural hole and brokerage research to consider alters as brokers, expanding the nature of ties to include negative, multiplex/dissonant, and dormant ties, and exploring the value of redundant ties. The challenge is to answer the question “What's next in social network analysis? ” Expected final online publication date for the Annual Review of Organizational Psychology and Organizational Behavior, Volume 9 is January 2022. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
The Strongest Negative Lightning Strokes in Winter Thunderstorms in Japan

Winter thunderstorms in Japan are well known for the frequent production of energetic positive cloud‐to‐ground (CG) lightning flashes. By contrast, strong negative CG flashes or negative return strokes in winter thunderstorms are largely unknown. In this study, we demonstrate that negative return strokes with peak currents larger than 150 kA (absolute value) in winter thunderstorms in Japan mostly produce electric field change waveforms that are different from those of normal return strokes. Due to their unusual waveforms, these strongest negative strokes have not been recognized as return strokes by the lightning research community. We further demonstrate that these strong negative return strokes are preceded by a fast downward negative leader with a short duration and strong peak current. We suggest that the fast and powerful downward negative leader may be associated with downward terrestrial gamma‐ray flashes. We also present evidence that these strong negative strokes are likely “superbolts” observed from space.
Detection of Knockdown-Resistance Mutations (V1016G and F1534C) in Dengue Vector from Urban Park, Surabaya, Indonesia

An urban park is potentially a source of vector-borne disease transmission due to it being a natural and artificial mosquito breeding habitats combined with people's continuous presence. Thus, this study aims to screen the occurrence of knockdown-resistance (kdr) mutant alleles (V1016G and F1534C) in mosquito populations collected from urban parks in Surabaya, Indonesia. Cross sectional study was conducted in July 2019. A total of 28 ovitraps were installed in seven urban parks, having four ovitraps installed in each park. In total, 1,662 eggs were collected, and only 187 emerged into adult mosquitoes, consisting of 97 Aedes (Stegomyia) aegypti and 90 Aedes (Stegomyia) albopictus. All-female adult mosquitoes (n=55) were tested using allele-specific polymerase chain reaction assay (AS-PCR) to detect voltage gated sodium channel (VGSC) gene mutations. This study found no mutations in Valine to Glysine mutation in point 1016 (V1016G) and Phenylalanine to Cysteine in point 1534 (F1534C) alleles in both two species. All of mosquito samples have wild type genotype of kdr alleles (V1016V and F1534F). Data were analysed using R Studio 1.4 Version by Genetics package. Results showed that the frequency of resistant alleles (G1016 and C1534) was zero, and the frequency of susceptible allele was 1 (V1016 and F1534). Insecticide bioassay could not be established due to the limited number of adult mosquitoes, so insecticide resistance status could not be determined. However, this study can be used as preliminary monitoring for the vector control program.
Effect of Nitrogen Doping on the Optical Bandgap and Electrical Conductivity of Nitrogen-Doped Reduced Graphene Oxide

Graphene as a material for optoelectronic design applications has been significantly restricted owing to zero bandgap and non-compatible handling procedures compared with regular microelectronic ones. In this work, nitrogen-doped reduced graphene oxide (N-rGO) with tunable optical bandgap and enhanced electrical conductivity was synthesized via a microwave-assisted hydrothermal method. The properties of the synthesized N-rGO were determined using XPS, FTIR and Raman spectroscopy, UV/vis, as well as FESEM techniques. The UV/vis spectroscopic analysis confirmed the narrowness of the optical bandgap from 3.4 to 3.1, 2.5, and 2.2 eV in N-rGO samples, where N-rGO samples were synthesized with a nitrogen doping concentration of 2.80, 4.53, and 5.51 at. %. Besides, an enhanced n-type electrical conductivity in N-rGO was observed in Hall effect measurement. The observed tunable optoelectrical characteristics of N-rGO make it a suitable material for developing future optoelectronic devices at the nanoscale.
STRUCTURAL DIVERSITY AMONG CELLULAR ADHESION RECEPTORS: FIBRINOGEN BINDING IS A NOVEL BIOLOGICAL PROPERTY OF THE MONOCYTE DIFFERENTIATION ANTIGEN OKM1

A family of related glycoproteins (GP) mediate the interaction between the circulating adhesive proteins and a variety of cells (cytyoadhesins). In this study we have compared two cell-surface antigens which share the property to bind fibrinogen: the platelet GP IIb/IIIa, prototype of the cytoadhesins, and the receptor for fibrinogen costitutively synthesized by monocytes. Two anti-GP IIb/IIIa monoclonal antibodies (Mabs) (LJP9, LJP5), recognizing functionally distinct epitopes of the GP IIb/IIIa did not react with monocytes nor inhibited 125I-fibrinogen binding to monocytes. Similarly, an Arg-Gly-Asp containing peptide which completely abolished platelet-fibrinogen interaction, had no effect on monocytes. Structurally, the monocyte fibrinogen receptor was dimeric and composed of two subunits with molecular weight (Mr) of 155,000 and 95,000. This structural organization was different from that of the GP IIb/IIIa (Mr= 116,000), but in close analogy with the family of leukocyte differentiation antigens OKM1, LFA-1. Therefore, this possible relationship was investigated. A Mab to OKM1 antigen (10 μg/ml) completely suppressed fibrinogen binding to monocytes while it was ineffective on plateles. Iodinated monocyte lysate subjected to immunoprecipitation with OKM1 Mab (60 μg/ml) showed a dimeric antigen with the same molecular size of the monocyte fibrinogen receptor. Moreover, preclearing of the monocyte lysate with OKM1 Mab removed the immunoprecipitate corresponding to the monocyte fibrinogen receptor. These data indicate that the immunologic differentiation antigen OKM1, in addition to function as a complement receptor, displays also the novel biological adhesion property to mediate the binding of fibrinogen to monocytes.
Early albumin level and mortality in hemodialysis patients: a retrospective study.

BACKGROUND Hypoalbuminemia is a significant risk factor of cardiovascular disease and all-cause death in patients undergoing conventional hemodialysis (HD). However, the albumin (ALB) level of these dialysis patients runs through the whole process of dialysis, and the prognostic value of serum ALB in the early stage of HD and the relationship between the early ALB value and death in HD patients has not been reported. METHODS The data of 447 patients with HD were retrospectively analyzed. The patients were stratified into three ALB (g/L) groups: low, ALB ≤34.2; moderate, 34.3< ALB <40.1; high, ALB ≥40.2. Survival trends of the three groups were analyzed by the Kaplan-Meier method. RESULTS Comparison of the clinical data among the three groups showed a positive correlation between Hb, RBC, K+, Ca2+, Mg2+, and PHOS (P<0.05), but a negative correlation between age and high-sensitivity C-reactive protein (hsCRP) (P<0.05). The ALB level in early HD patients was an independent predictor of death [hazard ratio (HR) =0.945; 95% confidence interval (CI): 0.916-0.976; P=0.000], while age and hsCRP were protective factors (HR =1.048, 95% CI: 1.028-1.067, P=0.000; HR =1.049, 95% CI: 1.024-1.075, P=0.000). The estimated median overall survival (OS) at early HD was 56.00 months in the low ALB group, 83.00 months in the moderate ABL group, and 95.00 months in the high ALB group. The Kaplan-Meier estimate of survival showed a significant difference in OS among the three groups (log-rank P=0.000). CONCLUSIONS The early ALB level not only reflects the nutritional and chronic inflammation status of HD patients, but can also predict the prognosis, which has guiding significance for the management of HD patients.
Me, My Smartphone, and I: Development of the Smartphone Orientation Scale (SOS)

ABSTRACT The smartphone has become an integral part of modern life. Many people cannot imagine a life without their smartphone. The sole focus of this research is to create and validate a measure of smartphone orientation to reflect individuals’ interactions with their smartphones as a part of their everyday lifestyle. Presently, the literature offers a variety of smartphone addiction scales of which many suffer from inadequate assessment of the scale’s reliability, validity, theoretical underpinnings, and most scales have too many items. Additionally, research suggests that several of these scales are only weakly associated with actual smartphone use. Across three studies and 867 respondents, a rigorous process was undertaken to create and validate the Smartphone Orientation Scale (SOS). Study 1 involved defining smartphone orientation, creating the scale items, and using a survey of 288 US adults to assess the scale’s psychometric properties and nomological validity; scale analysis resulted in an 8-item SOS scale which exhibits both convergent and discriminant validity. Study 2 surveyed 163 undergraduates to further assess the validity of the SOS; results provide evidence of discriminant, convergent, and nomological validity. Study 3 utilized a survey of 416 undergraduates and found that the SOS was positively associated with social media usage, social media intensity, and actual smartphone use. Overall, the above research offers a valid, 8-item scale that can be used to measure the intensity of an individual’s smartphone orientation. Recent research shows that how we relate to our technology impacts our well-being. Future research directions and study limitations are also discussed.
Inhomogeneous and Radiating Composite Fluids

We consider the energy conditions for a dissipative matter distribution. The conditions can be expressed as a system of equations for the matter variables. The energy conditions are then generalised for a composite matter distribution; a combination of viscous barotropic fluid, null dust and a null string fluid is also found in a spherically symmetric spacetime. This new system of equations comprises the energy conditions that are satisfied by a Type I fluid. The energy conditions for a Type II fluid are also presented, which are reducible to the Type I fluid only for a particular function. This treatment will assist in studying the complexity of composite relativistic fluids in particular self-gravitating systems.
The Cognitive-Affective-Motivation Model of Learning (CAMML): Standing on the Shoulders of Giants

The Cognitive-Affective-Motivation Model of Learning (CAMML) is a proposed framework for integrating contemporary motivation, affective (Big 5 personality) and cognitive (CHC theory) constructs in the practice of school psychologists (SPs). The central tenet of this article is that SPs need to integrate motivation alongside affective and cognitive constructs vis-à-vis an updated trilogy-of-the-mind (cognitive, conative, affective) model of intellectual functioning. CAMML builds on Richard Snow’s seminal research on academic aptitudes—which are not synonymous with cognitive abilities. Learning aptitude complexes are academic domain-specific cognitive abilities and personal investment mechanisms (motivation and self-regulation) that collectively produce a student’s readiness to learn in a specific domain. CAMML incorporates the “crossing the Rubicon” commitment pathway model of motivated self-regulated learning. It is recommended SPs take a fresh look at motivation theory, constructs, and research, embedded in the CAMML aptitude framework, by going back-to-the-future guided by the wisdom of giants from the field of cognition, intelligence, and educational psychology.
Zaia transmission ' ' between sexual partners confers protection against HIV-1 In vivo evidence insufficient to conclude that ' ' KIR / HLA incompatibility

http://bloodjournal.hematologylibrary. org/content/122/11/1983.full. html Updated information and services can be found at: (5140 articles) Immunobiology  Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary. org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary. org/site/misc/rights.xhtml#reprints Information about ordering reprints may be found online at: http://bloodjournal.hematologylibrary. org/site/subscriptions/index.xhtml Information about subscriptions and ASH membership may be found online at:
Low-temperature synthesis of high-quality graphene by controlling the carbon-hydrogen ratio of the precursor

A furnace-free inductively coupled plasma chemical vapor deposition (ICP-PECVD) system, which does not require sample heating, was used to grow graphene at a temperature below 300 °C. This studies have found that under low-temperature PECVD growth conditions, liquid precursors are more suitable for preparing low-temperature graphene precursors than gaseous precursors. Hence, benzene is used as a carbon precursor to obtain a sheet resistance of approximately 1.24 kΩ sq−1. In this research, it was discovered that the carbon-hydrogen ratio of the precursor molecule is an important factor while using PECVD to grow graphene. This factor affects the quality of graphene and the sheet resistance value —when the carbon–hydrogen ratio for the precursor molecule is 1:1, graphene has the high quality and lowest sheet resistance; when it is less than 1:2, the graphene that cannot be deposited has the worst quality and sheet resistance. Furthermore, we found that methane, a precursor often used to deposit graphene, will etch graphene under low-temperature conditions, and that acetylene can be used as a precursor to deposit graphene. It was further proven that the carbon–hydrogen ratio of the precursor molecules in the PECVD process caused the reduction in the graphene temperature.
Determination of chlorine by fluorescence quenching

Determination of Chlorine by Fluorescence Quenching by Yixin Wei Dr. Brian J. Johnson. Examination Committee Chair Associate Professor o f Chemistry University o f Nevada, Las Vegas Chlorine is used extensively in the chemical industry and for disinfection of drinking water. Many methods have been reported for the determination o f chlorine species. Fluorescence quenching to determine chlorine is a promising method because o f its high sensitivity and selectivity. This study focuses on development o f a sulfonamidebased collection system for low levels o f chlorine in air. Quantitation o f chlorine is based on the quenching of the fluorescence signal observed when chlorine reacts with the fluorescent sulfonamide compound. Both a direct fluorimetric and a fluorescence-HPLC method have been established. Linear relationships are found between the fluorescence intensity or HPLC peak area and the amount o f chlorine. Detection limits are in the ppb range or better. These methods have been applied to water samples. Experiments have also shown that sulfonamide-treated dihydroxypropylated silica can effectively collect gas-phase chlorine.
Non-invasive mechanical ventilation in COPD

Treatment of COPD include many pharmacological and non pharmacological interventions but still smoking cessation is the most important action. The main stay of pharmacological treatment is inhaled bronchodilators and inhaled steroids if FEV1 less than 50%. The non pharmacological interventions include quit smoking, pulmonary rehabilitation, Non invasive mechanical ventilation (NIMV) and surgical procedures (lung volume reduction surgery, bullectomy, lung transplantation) together with nutritional, social and psychiatric management [2,3].
Physiological and biochemical studies on the protective effect of Ficus carica leaf extract, vitamin C or their combination on liver toxicity induced by lead acetate in male rats

Introduction: Lead is an environmental contaminant, which is toxic to organ systems in human and other animals. The present study investigated the possible protective role of Ficus carica leaf extract, vitamin C or the combined treatment in lead acetate-induced hepatotoxicity. Methods: One hundred and twenty-six adult male albino rats were divided into seven groups (n = 18). G1 (control group) received distilled water. G2 (lead acetate group) received lead acetate at a daily dose of 20 mg/kg body weight by gastric gavage. G3 (Ficus carica group) received Ficus carica leaves extract at a daily dose of 200 mg/kg body weight by gastric gavage. G4 (Ficus and lead group) received Ficus carica leaves extract followed by lead acetate after 20 minutes. G5 (vitamin C group) received vitamin C at a daily dose of 200 mg/kg body weight by gastric gavage, G6 (vitamin c and lead group) received vitamin C followed by lead acetate after 20 minutes. And, G7 (Ficus, vitamin C, and lead group) received Ficus carica leaves extract and vitamin C followed by lead acetate after 20 minutes. The treatment extended for six weeks, blood and specimens were collected at a 2-week interval. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total protein (TP), direct bilirubin (DB), lipid peroxidation biomarker (Malondialdehyde (MDA)), antioxidants enzymes (Superoxide dismutase (SOD) and reduced glutathione (GSH)) in liver tissue and histopathological changes in liver were investigated. Results: Lead acetate caused significant increases in AST, ALT, ALP, DB and MDA levels. In addition, TP and level of SOD and GSH significantly decreased compared to the control group. The pre-treatment with the combination of Ficus carica and vitamin C improved liver parameters, the level of antioxidant enzymes as well as histopathological changes. Conclusion: The combination of Ficus carica leaf extract and vitamin C had a remarkable protective action against lead acetate induced- oxidative damage in rats.
Integrating melt-electrowriting and inkjet bioprinting for engineering structurally organized articular cartilage

Successful cartilage engineering requires the generation of biological grafts mimicking the structure, composition and mechanical behaviour of the native tissue. Here melt-electrowriting (MEW) was used to produce arrays of polymeric structures whose function was to orient the growth of cellular aggregates spontaneously generated within these structures, and to provide tensile reinforcement to the resulting tissues. Inkjeting was used to deposit defined numbers of cells into MEW structures, which self-assembled into an organized array of spheroids within hours, ultimately generating a hybrid tissue that was hyaline-like in composition. Structurally, the engineered cartilage mimicked the histotypical organization observed in skeletally immature synovial joints. This biofabrication framework was then used to generate scaled-up (50mm × 50mm) cartilage implants containing over 3,500 cellular aggregates in under 15 minutes. After 8 weeks in culture, a 50-fold increase in the compressive properties of these MEW reinforced tissues were observed, while the tensile properties were still dominated by the polymer network, resulting in a composite construct demonstrating tension-compression nonlinearity mimetic of the native tissue. Helium ion microscopy further demonstrated the development of an arcading collagen network within the engineered tissue. This hybrid bioprinting strategy provides a versatile and scalable approach to engineer cartilage biomimetic grafts for biological joint resurfacing.
Educational Setting and SARS-CoV-2 Transmission Among Children With Multisystem Inflammatory Syndrome: A French National Surveillance System

Background: Multisystem inflammatory syndrome in children (MIS-C) is the most severe form associated with SARS-CoV-2 infection in children. To reduce the spread of SARS-CoV-2 at the population level, educational setting closure have been implemented in many countries. However, the direct benefit of school closure on the MIS-C burden remains to be explored. We aimed to assess the role of educational settings in SARS-CoV-2 transmission among children with MIS-C. Methods: We conducted a French national prospective surveillance of MIS-C, coordinated by Public Health France, from April 2020 to March 2021. During this period, we included all children with MIS-C fulfilling the WHO definition who were reported to Public Health France. For each child, we traced the source of SARS-CoV-2 transmission. The main outcome was the proportion of children with MIS-C, with educational setting-related SARS-CoV-2 infection, during the period of school opening. Results: We included 142 children fulfilling WHO criteria for MIS-C: 104 (70%) cases occurred during school opening periods. In total, 62/104 children (60%, 95%CI [50; 69]) had been contaminated by a household contact and 5/104 in educational settings (5%, 95%CI [2; 11]). Among children with MIS-C occurring during school closure periods, the proportion of household transmission remained similar (66%, 25/38). Conclusion: Children with MIS-C were mainly infected by SARS-CoV-2 within their family environment, and the educational setting played a marginal role in this transmission. This suggests that mitigating school attendance may not reduce substantially the burden of MIS-C.