Miracle-dz/UniFAR-FTUs huggingface dataset:
On the Software Interface Design

As the key of IT industry and the foundation of IT economy,software industry has been paid more and more attentions by every country of the world.Software is a type of tools and information exchange between software and user occurs through software interface.Therefore,the properties of a software interface,such as user-friendly and overall appearance of the software interface become very important.The designer should follow the principles of user-interface design as well as regulations of software design for a software interface design.
Emulating the GRADE trial using real world data: retrospective comparative effectiveness study

Abstract Objective To emulate the GRADE (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study) trial using real world data before its publication. GRADE directly compared second line glucose lowering drugs for their ability to lower glycated hemoglobin A1c (HbA1c). Design Observational study. Setting OptumLabs® Data Warehouse (OLDW), a nationwide claims database in the US, 25 January 2010 to 30 June 2019. Participants Adults with type 2 diabetes and HbA1c 6.8-8.5% while using metformin monotherapy, identified according to the GRADE trial specifications, who also used glimepiride, liraglutide, sitagliptin, or insulin glargine. Main outcome measures The primary outcome was time to HbA1c ≥7.0%. Secondary outcomes were time to HbA1c >7.5%, incident microvascular complications, incident macrovascular complications, adverse events, all cause hospital admissions, and all cause mortality. Propensity scores were estimated using the gradient boosting machine method, and inverse propensity score weighting was used to emulate randomization of the treatment groups, which were then compared using Cox proportional hazards regression. Results 8252 people were identified (19.7% of adults starting the study drugs in OLDW) who met eligibility criteria for the GRADE trial (glimepiride arm=4318, liraglutide arm=690, sitagliptin arm=2993, glargine arm=251). The glargine arm was excluded from analyses owing to small sample size. Median times to HbA1c ≥7.0% were 442 days (95% confidence interval 394 to 480 days) for glimepiride, 764 (741 to not calculable) days for liraglutide, and 427 (380 to 483) days for sitagliptin. Liraglutide was associated with lower risk of reaching HbA1c ≥7.0% compared with glimepiride (hazard ratio 0.57, 95% confidence interval 0.43 to 0.75) and sitagliptin (0.55, 0.41 to 0.73). Results were consistent for the secondary outcome of time to HbA1c >7.5%. No significant differences were observed among treatment groups for the remaining secondary outcomes. Conclusions In this emulation of the GRADE trial, liraglutide was statistically significantly more effective at maintaining glycemic control than glimepiride or sitagliptin when added to metformin monotherapy. Generating timely evidence on medical treatments using real world data as a complement to prospective trials is of value.
Analysis of the current state of acupuncture clinical trial registration and reporting: for the past 9 years

Background: An increasing number of acupuncture clinical trials are being registered, but the reports of results and data transparency are unclear. This paper aims to analyze and evaluate the current state of registration and reports of acupuncture clinical studies and seek feasible solutions to improve the quality of acupuncture clinical studies, leading to minimizing waste of public resources and effectively providing a reliable evidence-based basis for clinical practice. Methods: This paper will focus on the acupuncture clinical trials that met the criteria in relevant studies registered and published during the period between 1 Jan 2013 to 31 Dec 2021.The search and registration platforms were the Clinicaltrials.gov and the Chinese Clinical Trial Registry (ChiCTR). The literature search platforms were Web of Science, PubMed, CNKI, WanFang, VIP, and China Biomedical Literature Database (SinoMed). Results: A total of 403 trials were included in ChiCTR and 519 trials were included in Clinicaltrials.gov. The overall reporting rate of acupuncture clinical trial results from the two registration centres was was 25%. Clinicaltrials.gov reporting rate was 12% and that from ChiCTR was 41%. Conclusion: The number of acupuncture clinical trial registrations is steadily increasing, but the reporting rate of trial results is relatively low and the transparency of data is not ideal. Due to the fact that the unavailability of the registered trial results caused a waste of research resources and funds, there is a shortage of research in the relevant area. Therefore, first of all, researchers should put more attention on clinical trial reports in acupuncture and respect science; secondly, it is recommended to set up a research progress tracker on registration platforms accessible to the public users, which contributes to the supervision of research projects; at the same time, the journal is suggested that also adjust the evaluation criteria for reporting the negative results to reduce the probability of results bias; most importantly, the government is recommended to optimize the closing review, strengthen the monitoring of core outcome indicators, standardize clinical reports to reduce the waste of public resources.
Analysis of the genetic diversity of SARS-CoV-2 genomes carrying the Omicron B.1.1.529 mutation

In this work, we evaluated the levels of genetic diversity in 95 genomes of the carriers of the Omicron B.1. 1.529 mutation in SARS-CoV-2 from South Africa, Asia, Massachusetts-USA, Rhode Island-USA, United Kingdom and Germany. All with 29,996pb extension and recovered from GENBANK and publicly available at the National Center for Biotechnology and Information (NCBI). All gaps and conserved sites were extracted for the construction of a phylogenetic tree and for specific methodologies of estimates of paired FST, Molecular Variance (AMOVA), Genetic Distance, Incompatibility, demographic expansion analyses, molecular diversity and of evolutionary divergence time analyses, always with 20,000 random permutations. The results revealed the presence of only 75 parsimony-informative sites, sites among the 29,996bp analyzed. The analyses based on FST values, confirmed the absence of distinct genetic structuring with fixation index of 98% and with a greater component of population variation (6%) for a "p" 0.05. Tau variations (related to the ancestry of the groups), did not reveal significant moments of divergence, supported by the incompatible analysis of the observed distribution ({tau} = 0%). It is safe to say that the large number of existing polymorphisms reflects major changes in the protein products of viral populations in all countries and especially In South Africa. This consideration provides the safety that, because there are large differences between the haplotypes studied, these differences are minimal within the populations analyzed geographically and, therefore, it does not seem safe to extrapolate the results of polymorphism and molecular diversity levels found in the Variant Omicron B.1.529 of SARS-CoV-2 for wild genomes or other mutants. This warns us that, due to their higher transmission speed and infection, possible problems of molecular adjustments in vaccines already in use may be necessary in the near future.
Remote/Local offloading of mobile applications as an energy saving strategy

1 Resum . 2 Resumen . 3 Acknowledgements . 5 Revision history and approval record . 6 Table of contents . 7 List of Figures . 9 List of Tables . 10
Application of Chaos Optimization Technology in Pump Station

In this paper, the chaos is used to solve the problem of optimization in pump station, the result is the same by the dynamic programming method. the new method is not only simple and easy to implement,but also has both high accuracy and reliability, it is an effective way for solving the problem of optimization in pump station. 
Frequency Modulated Continuous Wave Radar

The need to see without being seen has been the cardinal principle of military commanders since the inception of warfare. Until the advent of World War II, the only means available to commanders from this point of view was espionage and intelligence gathering missions behind enemy lines. Just prior to World War II, the allies came up with a ground breaking invention, the pulsed radar. This invention radically altered the equation and for the first time in the true sense of the term one could see without being seen. The word RADAR is an acronym for Radio Detection And Ranging. As it was originally conceived, radio waves were used to detect the presence of a target and to determine its distance or range. The pulsed radar could sight the German lighter formations well before they reached the English coast and could, therefore, concentrate allied lighter groups where they were most needed. The German lighters were not even aware that they were detected. In effect, the pulsed radar acted as a force multiplier and helped the allies defeat the vastly superior Luftwaffe in the Battle of Britain. The allies pressed home their advantage of having the radar, by going on to win the Battle of the Atlantic against the German U-Boats by catching them unawares on the surface at nighttime when they were charging their batteries. This was truly stealth warfare in the purest sense of the term. The German reaction to these events was slow and by the time they came up with their own radars and radar emission detectors (now called intercept receivers) it was too little, too late to influence the outcome of the war in their favor.
NEUVis: Comparing Affective and Effective Visualisation

Data visualisations are useful for providing insight from complex scientific data. However, even with visualisation, scientific research is difficult for non-scientists to comprehend. When developed by designers in collaboration with scientists, data visualisation can be used to articulate scientific data in a way that non-experts can understand. Creating human-centred visualisations is a unique challenge, and there are no frameworks to support their design. In response, this thesis presents a practice-led study investigating design methods that can be used to develop Non-Expert User Visualisations (NEUVis), data visualisations for a general public, and the response that people have to different kinds of NEUVis. For this research, two groups of ten users participated in quantitative studies, informed by Yvonna Lincoln and Egon Guba’s method of Naturalistic Inquiry, which asked non-scientists to express their cognitive and emotional response to NEUVis using different media. The three different types of visualisations were infographics, 3D animations and an interactive installation. The installation used in the study, entitled 18S rDNA, was developed and evaluated as part of this research using John Zimmerman’s Research Through Design methodology. 18S rDNA embodies the knowledge and design methods that were developed for this research, and provided an opportunity for explication of the entire NEUVis design process. The research findings indicate that developing visualisations for the non-expert audience requires a new process, different to the way scientists visualise data. The result of this research describes how creative practitioners collaborate with primary researchers and presents a new human-centred design thinking model for NEUVis. This model includes two design tools. The first tool helps designers merge user needs with data they wish to visualise. The second tool helps designers take that merged information and begin an iterative, user-centred design process.
Prevalence of metabolic syndrome and its association with suicidality in depressed patients admitted to psychiatry inpatient unit

Aim: To assess the prevalence and correlates of metabolic syndrome in patients with depression admitted to psychiatry inpatient unit. Methodology: By using retrospective study design, the treatment records data of 476 consecutiveadmitted patients diagnosed with depressive disorders (first episode or recurrent depressive disorder) as per the ICD-10, were reviewed and data for metabolic syndrome was extracted. Results: Slightly less than half (45.8%) of the patients fulfilled the criteria for metabolic syndrome as per the consensus definition. The mean age of the study participants was 46.22 (SD: 16.87) years and the mean number of years of education was 11.19 (SD: 4.70) years. The mean duration of illness was 110.47 (SD: 107.93) months with the mean duration of current episode at the time of collection of data was 10.44 (SD: 9.76) months. Higher proportion of those with metabolic syndrome were older in age, were more educated, of female gender, had longer duration of illness, were more often diagnosed with recurrent depressive disorder and had presence of physical comorbidities. Lifetime Suicidality had significant association with abnormal blood pressure and raised blood glucose level. However, presence of absence of metabolic syndrome had no association with metabolic syndrome. Conclusions: The high prevalence of metabolic syndrome in patients with depressive disorders, suggests that there is a need to closely monitor the patients with depressive disorders for metabolic syndrome.
The Venetoclax/Azacitidine Combination Targets the Disease Clone in Acute Myeloid Leukemia, Being Effective and Safe in a Patient with COVID-19

The addition of Venetoclax (VEN) to Hypomethylating agents (HMAs) significantly improves the probability of complete remission and prolongs survival in patients with Acute Myeloid Leukemia (AML) when compared to HMA alone. However, the mutated clone composition may impact the probability of response and its duration. Here, we describe the molecular profile of a patient with AML rapidly evolved from a previous therapy-related-Chronic MyeloMonocytic Leukemia, who achieved safely complete remission after treatment with the VEN/Azacitidine combination, even in the presence of SARS-COVID-2 infection. The targeted NGS analysis showed that the VEN/AZA combination led to the eradication of the FLT3-ITD and RUNX1 mutated clone/s primarily associated with AML evolution, and subsequently, the SRSF2, NRAS, and ASXL1 mutated clone/s. This case also underlines the importance of the sequential use of targeted NGS for disease monitoring: the deep molecular remission achieved by this patient allowed to safely guide adjustments of drug dosage and treatment intervals in the presence of neutropenia, helping to rule out disease progression.
De Novo and Therapy-Related Myelodysplastic Syndromes: Analogies and Differences

The aim of our review has been to give an appropriate idea of analogies and differences between primitive MDS (p-MDS) and t-MDS throughout an accurate reviewing of English peer-reviewed literature focusing on clinical, cytogenetic, epigenetic, and somatic mutation features of these two groups of diseases. Therapy-related MDS (t-MDS) are classified by WHO together with therapy-related acute myeloid leukemia (t-AML) in the same group, named therapy-related myeloid neoplasm. However, in clinical practice, the diagnosis of t-MDS is made with the same criteria as for primitive MDS (p-MDS), and the only difference is a previous non-myeloid neoplasm. The prognosis and the consequent therapy can be established following the same criteria as for p-MDS, and the therapy is generally decided using the same criteria. We stress the possible difference in cytogenetics, mutations, and epigenetics to distinguish the two forms. Actually, there is no marker specific for t-MDS either in cytogenetics, epigenetics, or mutations; however, some alterations are also frequent in t-MDS and, in general, they induce a poorer prognosis. So, the high-risk forms in t-MDS are prevalent. The present literature data suggest classifying the t-MDS as a subgroup of MDS and introducing some parameters to evaluate the probability of previous therapy in inducing MDS. An important issue remains the patient’s fitness, which strongly influences the outcome.
Analysis of the electromagnetic acoustic noise and vibrations of a high-speed brushless DC motor

In this paper, the acoustic noise and vibrations due to Maxwell forces of a 4-pole, 12-slot, high-speed brushless DC motor (BLDC) is analysed up to 90 kRPM. The harmonic magnetic forces present in the machine are first analytically characterized, and validated with numerical simulations using MANATEE® electromagnetic and vibro-acoustic software. The effects of rotor vibrations due to bearing faults, pole displacements and eccentricities are considered. Finally, some complete experimental measurements relying on “spatiogram” techniques are run to characterize the vibration waves (wavenumber and frequency) involved in acoustic noise generation. These results are compared to simulations and it is demonstrated that the observed high acoustic noise is due to machine imperfections creating harmonic forces exciting the bending mode of the shaft and the stator elliptical mode.
A HIERARCHY OF MODELS FOR MULTILANE VEHICULAR TRAFFIC II: NUMERICAL INVESTIGATIONS

In this paper the work presented in (A. Klar and R. Wegener, A hierarchy of models for multilane vehicular trac I: Modeling, SIAM J. Appl. Math., 59 (1999), pp. 983{1001) is contin- ued. The present article contains detailed numerical investigations of the models developed there. A numerical method to treat the kinetic equations obtained in the aforementioned paper is presented. Space homogeneous and inhomogeneous situations are considered.
Behavioural activation for co- morbid depression in people with non-communicable disease in India: Protocol for a randomised controlled feasibility trial (BEACON)

Introduction: The increasing burden of depression and non-communicable disease (NCD) is a global challenge, especially in low- and middle-income countries (LMIC) considering the resource constraints and lack of manpower in these settings. Brief psychological therapies such as behavioural activation (BA), have shown to be effective for the treatment of depression. However, their feasibility and effectiveness for depression in people with NCDs in Indian community setting has not been systematically evaluated. Hence, in this study, we conceptualize to adapt BA into Indian NCD context, thus to improve the management of depression in people with NCD in India. Aims: To (1) adapt BA for the Indian NCD context, (2) test the acceptability, feasibility and implementation of the adapted BA intervention (BEACON intervention package, BIP), and (3) test the feasibility of a randomised controlled trial evaluation of BIP for the treatment of depression compared with enhanced usual care. Methods: Following well-established frameworks for intervention adaptation, we first adapted BA (to fit the linguistic, cultural and resource context) for delivery in India. The intervention was also adapted for potential remote delivery via telephone. In a randomised controlled trial, we will then test acceptability, feasibility and implementation of the adapted BA intervention (BEACON Intervention package, BIP). We also test if a randomised controlled feasibility trial can be delivered effectively and estimate important parameters (e.g. recruitment and retention rates and completeness of follow up) needed to design a future definitive trial. Findings will be used to refine procedures for a future definitive trial evaluation of the effectiveness (and cost-effectiveness) of the BIP compared with enhanced usual care for the treatment of depression in NCDs. Ethics and dissemination: The study has received ethics approval by the University of York Health Sciences Research Governance Committee, UK; the Health Ministry Screening Committee, India; and the Ethics Committee (Behavioural Sciences Division), NIMHANS, Bangalore, India. Trial Registration: CTRI/2020/05/025048 [Registered on: 06/05/2020], http://ctri.nic. in This research was funded by the National Institute for Health Research (NIHR) (17/63/130) using UK aid from the UK Government to support global health research. The views expressed in this publication are those of the author(s) and not necessarily those of the NIHR or the UK government.
Men's preconception health and the social determinants of health: What are we missing?

Background Life course perspectives suggest that optimizing men's health before conception is requisite to equitably improve population health, an area of increasing public health focus. Although scholarship on the social determinants of health (SDOH) suggests that men's health and health behaviors do not occur in a vacuum, preconception health studies have not explicitly examined how these factors influence men's preconception health. Objective To identify latent classes of men's preconception health and the role of the SDOHs in predicting class membership. Methods Pooled data from the 2011–2019 male file of the National Survey of Family Growth were analyzed (n = 10,223). Latent class analysis (LCA) was used to identify distinct classes of men's preconception health. Eight manifest variables were used to fit latent class models. A classify-analyze approach was subsequently used to create a preconception health phenotype (PhP) outcome variable. SDOHs (exposure variable) were assessed in four domains (rural/urban residence, health access, socioeconomic status, and minority/immigrant status) to predict class membership. Survey-weighted multinomial regression models were fitted to examine the association between the exposure and the outcome. Results Three unique PhPs were identified (lowest risk (69%), substance users (22.9%), and sexual risk-takers (8.1%) from the LCA model. Health access, socioeconomic status, and minority/immigrant status were significant predictors of class membership but not rural/urban residence. Sexual risk takers were more likely to be uninsured (aOR: 1.25, 95% CI 1.02, 1.52), college-educated (aOR: 1.94 95% CI: 1.34, 2.79), and non-Hispanic Black (aOR: 1.99 95% CI: 1.55, 2.54) while substance users were more likely to have unstable employment (aOR: 1.23 95% CI:1.04, 1.45) and have a high school degree or higher (aOR 1.48 95% CI: 1.15, 1.90) than men in the lowest risk category. Conclusion Social determinants may impact men's preconception health in ways that are not conventionally understood. These findings raise important questions about how preconception health interventions should be created, tailored, and/or retooled. Specifically, studies that examine the sociocultural and political contexts underpinning the relationship between social class, masculinity, and men's preconception health are needed to provide nuanced insights on factors that shape these outcomes.