Miracle-dz/UniFAR-FTUs huggingface dataset:
Feasibility of an intervention for increasing moderate-to-vigorous intensity physical activity (MVPA) in primary school physical education: a study protocol

Background: Most primary school Physical Education (PE) has relatively little health-enhancing moderate-to-vigorous physical activity (MVPA). - A promising theory and evidence-based intervention, the ‘SHARP Principles’ model, has been effective in making PE lessons more active in one area of England. This protocol paper explains the rationale for use of the SHARP intervention, and the methods used to examine the feasibility and acceptability of a version of SHARP translated for use in Scotland (SHARP Scotland). Methods: The feasibility of SHARP Scotland will be evaluated by key areas of focus for feasibility studies: Acceptability, Implementation, Integration, Limited Efficacy Testing. A combination of process measures, including observations, session delivery records, accelerometry-data collection, questionnaires, and semi-structured qualitative focus groups with teachers and pupils will be used. The feasibility and suitability of the SHARP Scotland intervention for a future Randomised Control Trial (RCT) will be assessed. The study will involve children from 8-11 years old (Primary 4 to 6) in two schools, one large urban school, and one smaller school; four classes will be randomly assigned to the intervention group, and four classes randomly assigned to the usual-care (standard curriculum) control group. Within the 8-week intervention, MVPA in the intervention group will be targeted by encouraging class teachers to deliver their PE classes in more active ways, following SHARP Principles. A maximum of 64 PE lessons delivered in a SHARP way will be conducted to assess the effectiveness of the intervention. Discussion: The outcome of this study will be an assessment of whether applying the SHARP intervention is feasible in Scottish schools. Identification of any modifications to the intervention or evaluation which are required will provide insight for a fully powered effectiveness trial in the future, if appropriate.
A Nonlinear Subspace Approach for Parametric Estimation of PDFs from Short Data Records with Application to Rayleigh Fading

This paper tackles the issue of real-time parametric estimation of a wide class of probability density functions from limited datasets. This type of estimation addresses recent applications that require joint sensing and actuation. The suggested estimator operates in the nonlinear subspace that the parameter space of the distribution creates in the measurement sample space. This enables the estimator to embed a priori available information about the distribution in the computations to produce parameter estimates that are induced by signal components belonging only to the correct class of density functions being considered. It also enables it to nullify the effect of those components that do not belong to this class on the estimation process. The estimator can, with high accuracy, compute quickly the parameters of a wide class of probability density functions from short data records. The approach is developed and basic proofs of correctness are carried-out for the Rayleigh distribution, which is used to characterize wireless communication channels experiencing fast fading in heavily cluttered environments. Simulation results demonstrate the capabilities of the suggested procedure and the clear advantages it has over conventional norm-based estimation techniques. The results also show the ability of the suggested approach to estimate other density functions including the two-parameter lognormal distribution used to characterize shadowing in wireless communication.
Evaluation of Apoptotic Activity of Ethanolic Extract of Andrographis paniculata Linn in Human Hepatocellular Carcinoma Cell Lines

Introduction: Andrographis paniculata is one of the highly used potential medicinal plants in the world. This plant is traditionally used for the treatment of common cold, diarrhoea, fever due to several infective cause, jaundice, as a health tonic for the liver and cardiovascular health, and as an antioxidant. It is also used to improve sexual dysfunctions and serve as a contraceptive. All parts of this plant are used to extract the active phytochemicals, but the compositions of phytoconstituents widely differ from one part to another and with place, season, and time of harvest. Materials and Methods: All data obtained were analysed by Student t test using MS- Excel. The results were computed statistically using one way ANOVA.The reagents used were MTT [3-(4,5-dimethythiazol-2-yl) 2,5-diphenyl tetrazolium bromide]: 0.5 mg MTT/ml of serum-free DMEM, Solubilization solution: Dimethyl sulfoxide (DMSO)and Phosphate Buffered Saline (PBS; pH 7.4). The cytotoxic effects of lycopene Ag NP on 3T3 cells. Cells were treated with Lycopene Ag NP(10, 20, 30, 50, 100 and 200 μM) for 24 h, and cell viability was evaluated by MTT assay. Data are shown as means ± SD (n = 3). * compared with the control-blank group, p < 0.001. Results: The results were evaluated using three tests namely, MTT assay, Dual staining (acridine orange/ethidium bromide) and morphological changes. Conclusion: Different stages of apoptosis revealed the importance of A.paniculata in hepatocellular carcinoma cell lines. Andrographolide and analogues have been subjected to extensive chemico- biological investigations for anticancer drug development. Several andrographolide analogues have shown superior anticancer activities in both in vitro and in vivo models. Further clinical and biomedical studies are required to confirm the pharmacological, pharmaceutical and toxicological properties of andrographolide.
Delivery of the Nan'ao multi-terminal VSC-HVDC system

This paper provides an overview of the development and technology challenges of the world's first multi-terminal VSC-HVDC link that was successfully commissioned on 25th of December 2013. The link consists of three converter stations at three different geographic locations, connected by a combination of subsea DC cable, land DC cable and overhead DC line. A selection of the physical test results are provided including staged short-circuits.
NM23 Is a CP-Binding Protein Involved in Infectious Hypodermal and Hematopoietic Necrosis Virus Infection in Shrimp

Simple Summary In this study, we aimed to identify the putative host cell receptor for Infectious Hypodermal and Hematopoietic Necrosis Virus (IHHNV) CP(Capsid Protein) in the gill membrane of LitoPenaeus vannamei. We established that NM23 is a host cell binding partner for IHHNV CP. Our study is probably the first to address the host cell IHHNV receptor and could provide novel insights into the pathogenesis of IHHNV. We feel that this paper is of interest to the readers of Animals. Abstract The aim of this study was to identify the putative host cell receptor for Infectious Hypodermal and Hematopoietic Necrosis Virus (IHHNV) CP in the gill membrane of L. vannamei. Putative CP binding partners were screened first using a 2-dimensional Virus Overlay Protein Blot Assay (VOPBA) to probe isolated gill membrane proteins using recombinant CP. Putative binding partners were identified using mass spectrometry. A Phage Display Random Dodecapeptide Library was used to screen for dodecapeptides and motifs that bound to CP. Finally, putative binding pairs were confirmed using GST(glutathione-S-transferase) pulldown assays. 2-Dimensional VOPBA identified NM23 as a putative binding partner for IHHNV CP. GST pulldown experiments confirmed the direct interaction of NM23 and IHHNV CP. The phage display library was used to identify six groups of dodecapeptides that bound to CP. From these peptides, three characteristic binding motifs were identified, SW*Y, SKWV, and PQR. Interestingly, the SW*Y motif was also found in NM23. We are the first to implicate NM23 in IHHNV infection and postulate that it may bind to the CP using the SW*Y motif, although this remains to be confirmed.
Primary Hepatic Neuroendocrine Tumor With Ectopic Adrenocorticotropic Hormone Production

This report describes the case of a 63-year-old female with a metastatic neuroendocrine tumor (NET). Imaging studies revealed a primary hepatic NET (PHNET) originating in the porta hepatis and associated with extensive hepatic metastasis. This represents an extremely rare presentation of PHNET associated with ectopic adrenocorticotropic hormone (ACTH) production and hypercortisolism. As such, it is a unique presentation of an otherwise rare pathology and hence we believe it contributes to the literature on PHNETs by supplementing it with information on an uncommon variation of an infrequent pathology.
Physical Layer Security in an OFDM Time Reversal SISO Communication with Imperfect Channel State Information

A frequency domain time-reversal (TR) precoder is proposed to perform physical layer security in single-input single-output (SISO) systems using orthogonal frequency-division multiplexing (OFDM) and artificial noise (AN) injection. This scheme guarantees the secrecy of a communication towards a legitimate user, Bob, by exploiting the frequency diversity selective behaviour in multipath channels. The transmitter, Alice, has imperfect channel state information (CSI) of the legitimate link thanks to the channel reciprocity in time division duplex systems and does not know the instantaneous CSI of a potential eavesdropper, Eve. Three optimal decoding structures at Eve are considered in a block fading environment depending on the handshake procedure between Alice and Bob. Closed-form approximations of the signal-to-noise ratio required at Bob and the maximal CSI error that can be made at Alice, in order to guarantee a communication ergodic secrecy rate (ESR), are derived. Furthermore, the optimal amount of AN energy to inject, considering imperfect CSI, is also given as a closed-form expression. A trade-off on the choice of the spreading factor of the TR precoder is established between maximizing the ESR and decreasing the ϵ-achievable secrecy rate. Finally, thanks to these results, Alice can be a priori aware of the ESR over which she can establish a secure communication.
Clinical and Molecular Characteristics of Patients with PLN R14del Cardiomyopathy: State-of-the-Art Review

The deletion of the arginine 14 codon (R14del) in the phospholamban (PLN) gene is a rare cause of arrhythmogenic cardiomyopathy (ACM) and is associated with prevalent ventricular arrhythmias, heart failure, and sudden cardiac death. The pathophysiological mechanism which culminates in the ACM phenotype is multifactorial and mainly based on the alteration of the endoplasmic reticulum proteostasis, mitochondrial dysfunction and compromised Ca2+ cytosolic homeostasis. The symptoms of this condition are usually non-specific and consist of arrhythmia-related or heart failure-related manifestation; however, some peculiar diagnostic clues were detected, such as the T-wave inversion in the lateral leads, low QRS complexes voltages, mid-wall or epicardial fibrosis of the inferolateral wall of the left ventricle, and their presence should raise the suspicion of this condition. The risk stratification for sudden cardiac death is mandatory and several predictors were identified in recent years. However, the management of affected patients is often challenging due to the absence of specific prediction tools and therapies. This review aims to provide the current state of the art of PLN R14del cardiomyopathy, focusing on its pathophysiology, clinical manifestation, risk stratification for sudden cardiac death, and management.
Logistic Regression-Based Enterprise Credit Evaluation Model

In recent years, enterprises in Beijing have developed rapidly. As one of the economic centers in China, the integrity system of enterprises has become a hot topic. An objective and effective evaluation model for enterprises in Beijing can not only help consumers avoid consumption risks and provide reference for the government to formulate relevant policies, but also provide a reference for enterprises in choosing partners. The research objective of this paper is to construct a logistic regression-based enterprise credit evaluation model in Beijing. In the empirical study, 4648 Beijing enterprises were taken as samples, and the K-S test and Mann-whitey U test were used to test the correlation between test indicators and their correlation with explanatory variable y, and the qualified 6 test indicators were selected from the 15 indicators. KMO and Bartlett tests were used to test the six indicators to see whether they were suitable for principal component analysis. After principal component analysis of 6 indicators, the principal component factors obtained were taken into the binary logistic regression model as input variables, and the stepwise forward method based on maximum likelihood estimation was adopted to estimate the model parameters, so as to determine the final variables entering the model. Finally, test samples are used to test the accuracy of the model. The test results show that the model can predict the integrity of enterprises in Beijing.
Empirical Research on the Impact of Institutional Investors' Shareholding Ratio on Corporate Social Responsibility

Since the 21st century, China's economic development has been booming, which has promoted the growth of institutional investors and enabled them to play an increasingly important role in the capital market. On the other hand, in recent years, as the key investment object of institutional investors, listed enterprises have appeared a variety of social responsibility problems, revealing the lack of social responsibility of enterprises. Based on this, it is of great significance to study the impact of shareholding ratio of institutional investors on CSR and further put forward Suggestions on improving CSR performance.This article takes the manufacturing enterprises listed on a-share market from 2008 to 2011 as the sample, and studies the impact of the overall shareholding ratio of institutional investors on enterprises' social responsibility through empirical research. The research results show that institutional investors can promote enterprises to better undertake social responsibility, the listing time and scale of enterprises are positively correlated with social responsibility performance, and the return on equity has no significant impact on social responsibility performance. Finally, the article puts forward three Suggestions, which are to attach importance to the qualitative and quantitative research of corporate social responsibility, to promote institutional investors to actively participate in major corporate decisions, and to promote institutional investors to diversify.
Femtosecond laser corneal damage thresholds at 1540 nm and 2000 nm

Recently, pulsed lasers with ultrashort pulse durations have become ubiquitous in a variety of applications, including medical procedures such as laser eye surgery. These sources are capable of generating extremely high peak powers that can cause laser-induced tissue breakdown upon exposure. However, current laser safety standards do not provide exposure limits for wavelengths longer than 1400 nm and pulse durations shorter than 1 ns due to a lack of biological data. Instead, the recommendation is to limit the peak irradiance to the maximum permissible exposure (MPE) limits applicable to 1 ns pulse durations. We applied femtosecond laser pulses of varying energies at 1540 nm and 2000 nm to corneas of anesthetized rabbits. We used slit lamp biomicroscopy and optical coherence tomography to examine the exposure sites and determine the presence or absence of visible lesions 1 h and 24 h post-exposure. The dose-response data correlating the presence or absence of any alteration of the corneal surface to the pulse energy 1 h post-exposure was evaluated using probit analysis to extract the median effective dose (ED50) corresponding to the cornea damage threshold. We compared our results to the MPE limits applicable to 1 ns pulse durations and determined that the current safety standard procedures are not adequate to evaluate small diameter single pulse femtosecond exposures at 1540 nm and 2000 nm. The results of this study contribute to the knowledge base used for setting laser safety standards in the near infrared range for ocular exposure to ultrashort pulses.
The design of subsidized housing: towards an interdisciplinary and cross-national research agenda

Abstract Comparative housing studies traditionally focus on housing systems and social or economic policy, only rarely considering design issues. Through an examination of subsidized housing and its design in 20 countries, this paper explores how design research can benefit cross-national housing studies. Subsidized housing is essential to delivering decent and affordable homes, underpinning the right to housing. To relate design dimensions to housing systems, the analytical focus is on regulatory instruments, technical standards, and socio-spatial practices as well as housing providers, tenures, and target groups. Design research benefits the contextualization of housing systems and design outcomes in several ways. It reveals the contextual and contingent nature of regulatory cultures and instruments, socio-technical norms and standards, and socio-cultural expectations and practices that shape housing solutions. The paper concludes by considering productive ways architectural design research might contribute to an interdisciplinary housing research agenda by offering new means of theorization and analysis beyond traditional housing system typologies.
North Atlantic Ocean SST-gradient-driven variations in aerosol and cloud evolution along Lagrangian cold-air outbreak trajectories

Abstract. Atmospheric marine particle concentrations impact cloud properties, which strongly impact the amount of solar radiation reflected back into space or absorbed by the ocean surface. While satellites can provide a snapshot of current conditions at the overpass time, models are necessary to simulate temporal variations in both particle and cloud properties. However, poor model accuracy limits the reliability with which these tools can be used to predict future climate. Here, we leverage the comprehensive ocean ecosystem and atmospheric aerosol–cloud dataset obtained during the third deployment of the North Atlantic Aerosols and Marine Ecosystems Study (NAAMES3). Airborne and ship-based measurements were collected in and around a cold-air outbreak during a 3 d (where d stands for day) intensive operations period from 17–19 September 2017. Cold-air outbreaks are of keen interest for model validation because they are challenging to accurately simulate, which is due, in part, to the numerous feedbacks and sub-grid-scale processes that influence aerosol and cloud evolution. The NAAMES observations are particularly valuable because the flight plans were tailored to lie along Lagrangian trajectories, making it possible to spatiotemporally connect upwind and downwind measurements with the state-of-the-art FLEXible PARTicle (FLEXPART) Lagrangian particle dispersion model and then calculate a rate of change in particle properties. Initial aerosol conditions spanning an east–west, closed-cell-to-clear-air transition region of the cold-air outbreak indicate similar particle concentrations and properties. However, despite the similarities in the aerosol fields, the cloud properties downwind of each region evolved quite differently. One trajectory carried particles through a cold-air outbreak, resulting in a decrease in accumulation mode particle concentration (−42 %) and cloud droplet concentrations, while the other remained outside of the cold-air outbreak and experienced an increase in accumulation mode particle concentrations (+62 %). The variable meteorological conditions between these two adjacent trajectories result from differences in the local sea surface temperature in the Labrador Current and surrounding waters, altering the stability of the marine atmospheric boundary layer. Further comparisons of historical satellite observations indicate that the observed pattern occurs annually in the region, making it an ideal location for future airborne Lagrangian studies tracking the evolution of aerosols and clouds over time under cold-air outbreak conditions.
Investigating the altitude impact on the eco-phytochemical parameters of Ziziphora clinopodioides and Sophora alopecuroides in the different regions of northern Iran

Various environmental factors such as altitude significantly affect the pharmacological and chemical properties of the plant. Here, the effect of three different altitudes of 1800 m (Rineh region), 2300 m (Polur region) and 2800 m (Lar region) above sea level on growth traits, yield and compositions of essential oil of two medicinal plants (Ziziphora clinopodioides Lam and Sophora alopecuroides L.) during two successive years (2018 and 2019) was investigated. The results showed that increasing the altitude from 1800 to 2800 m above sea level increased the morphological traits such as height, side branch number, root length and root volume, however, decreased the dry and fresh weight of both Ziziphora and Sophora plants. In Sophora plant, increasing the altitude enhanced the yield of essential oil and the highest yield of essential oil was obtained in Lar region. However, in Ziziphora, elevating the altitude from 1800 to 2300 m decreased the yield of essential oil, but further increase to 2800 m significantly increased the yield of essential oil. In Ziziphora, the highest amount of sophoramine, sophoridane and sophocarpine compounds was obtained at 1800 m, while the highest rates of adenocarpine, vinylphenol and matridin was obtained at 2800 m. For Sophora, the highest amount of sophoramine and vinylphenol was obtained at 2300 m, while sophocarpine showed the highest rate at 2800 m. Therefore, altitude is one of the important parameters of natural ecosystems that effectively change the quantitative and qualitative parameters of medicinal plants.
The Effect of Knowledge Management and Talent Management on Employee Performance

Research objective are to see the impact of knowledge management and talent management on employee performance mediated by employee development. The sample of research is 225 employees who work in the field of information technology in the Jakarta area. Data analysis method using Structural Equation Model. The study showed that knowledge management and talent management have an impact on employee performance, the employee development variable is proven to be a mediation between knowledge management and employee performance, but the employee development variable cannot mediate between talent management and employee performance. Companies should provide knowledge management such as providing company web facilities as a place where employees can share their knowledge, and also develop talent management with training and development programs that will improve employee performance.
Hybrid Ray Tracing FDTD UWB-Model for Object Recognition

In this paper an approach for object recognition by the backscattered UWB signals is presented. This approach is a part of an UWB imaging and localization concept for emergency scenarios, where fire and smoke prevent using optical systems. The proposed recognition method is particulary useful to asses the intactness of the building construction elements. As such elements are usually composed of different materials, often including a metallic core, the recognition of inner structures is of great interest. For effective optimization and application of the recognition approach reference data sets are necessary. These reference data sets are obtained by a hybrid ray tracing/FDTD method, which allows for the simulation of small complex and inhomogenous objects in realsitc indoor scenarios. Index Terms – UWB imaging, IBST, Channel modeling, Ray tracing, FDTD