Miracle-dz/UniFAR-FTUs huggingface dataset:
Lymphocytic Leukemia B Cells Vitro Clonal Expansion of Chronic TLR-9 and IL-15 Synergy Promotes the In

Clinical progression of B cell chronic lymphocytic leukemia (B-CLL) reﬂects the clone’s Ag receptor (BCR) and involves stroma-dependent B-CLL growth within lymphoid tissue. Uniformly elevated expression of TLR-9, occasional MYD88 mutations, and BCR speciﬁcity for DNA or Ags physically linked to DNA together suggest that TLR-9 signaling is important in driving B-CLL growth in patients. Nevertheless, reports of apoptosis after B-CLL exposure to CpG oligodeoxynucleotide (ODN) raised questions about a central role for TLR-9. Because normal memory B cells proliferate vigorously to ODN+IL-15, a cytokine found in stromal cells of bone marrow, lymph nodes, and spleen, we examined whether this was true for B-CLL cells. Through a CFSE-based assay for quantitatively monitoring in vitro clonal proliferation/survival, we show that IL-15 precludes TLR-9–induced apoptosis and permits signiﬁcant B-CLL clonal expansion regardless of the clone’s BCR mutation status. A robust response to ODN+IL-15 was positively linked to presence of chromosomal anomalies (trisomy-12 or ataxia telangiectasia mutated anomaly + del13q14) and negatively linked to a very high proportion of CD38 + cells within the blood-derived B-CLL population. Furthermore, a clone’s intrinsic potential for in vitro growth correlated directly with doubling time in blood, in the case of B-CLL with Ig H chain V region–unmutated BCR and <30% CD38 + cells in blood. Finally, in vitro high-proliferator status was statistically linked to diminished patient survival. These ﬁndings, together with immunohistochemical evidence of apoptotic cells and IL-15–producing cells proximal to B-CLL pseudofollicles in patient spleens, suggest that collaborative ODN and IL-15 signaling may promote in vivo B-CLL growth. The Journal of Immunology , 2015, 195: 901–923. were each subdivided into high-proliferator clones ( . 50% of total viable cells with more than two DIV) or low-proliferator clones ( # 50% of total with more than two DIV). For OS, the differing groups were distributed in the following manner: total B-CLL: low = 21 censored, 1 death; high = 13 censored, 5 deaths; U-CLL: low = 10 censored, 0 deaths; high = 5 censored, 5 deaths; M-CLL: low = 11 censored, 1 death; high = 8 censored, 0 deaths. The U-CLL populations with diminished OS included CLL 1013 (TRI-12), CLL 430 (del11q22 + del13q14 + ATM mutation), CLL 675 (del11q22 + del13q14), CLL 1158 (del11q22 + del13q14), and CLL 996 (negative for tested FISH anomalies). Kaplan–Meier analysis was performed to discern whether the high-proliferator subgroup signiﬁcantly differed from the low-proliferator subgroup regarding TFT or OS. No signiﬁcant difference between subgroups was noted for TFT. Nonetheless, patients with high proliferator clones (total cohort and U-CLL cohort) appeared to have shortened OS as compared with those that did not ( p = 0.015 for total clones was statistically signiﬁcant; p = 0.083 for U-CLL clones approached signiﬁcance). There was no signiﬁcant difference in the OS of M-CLL clones with high- or low-proliferator status ( p = 1.00).
Low contact resistivity ohmic contacts to 6H-silicon carbide

The resistivity of ohmic contacts to N/sup +/ 6H-silicon carbide substrates, with Ti as the contact material, was studied using the circular TLM structure. Two dimensional numerical simulation of the circular TLM structures were performed to analyze the current distribution and its influence on the extraction procedure. A contact resistivity of 2/spl times/10/sup -5/ ohm-cm/sup 2/ was obtained without any high temperature anneal by using an N/sup +/ surface implant layer. This contact resistivity is an order of magnitude lower than any of the previously reported values for n-type 6H-silicon carbide. <<ETX>>
Inhalable Mannosylated Rifampicin–Curcumin Co-Loaded Nanomicelles with Enhanced In Vitro Antimicrobial Efficacy for an Optimized Pulmonary Tuberculosis Therapy

Among respiratory infections, tuberculosis was the second deadliest infectious disease in 2020 behind COVID-19. Inhalable nanocarriers offer the possibility of actively targeting anti-tuberculosis drugs to the lungs, especially to alveolar macrophages (cellular reservoirs of the Mycobacterium tuberculosis). Our strategy was based on the development of a mannose-decorated micellar nanoformulation based in Soluplus® to co-encapsulate rifampicin and curcumin. The former is one of the most effective anti-tuberculosis first-line drugs, while curcumin has demonstrated potential anti-mycobacterial properties. Mannose-coated rifampicin (10 mg/mL)–curcumin (5 mg/mL)-loaded polymeric micelles (10% w/v) demonstrated excellent colloidal properties with micellar size ~108 ± 1 nm after freeze-drying, and they remain stable under dilution in simulated interstitial lung fluid. Drug-loaded polymeric micelles were suitable for drug delivery to the deep lung with lung accumulation, according to the in vitro nebulization studies and the in vivo biodistribution assays of radiolabeled (99mTc) polymeric micelles, respectively. Hence, the nanoformulation did not exhibit hemolytic potential. Interestingly, the addition of mannose significantly improved (5.2-fold) the microbicidal efficacy against Mycobacterium tuberculosis H37Rv of the drug-co-loaded systems in comparison with their counterpart mannose-free polymeric micelles. Thus, this novel inhaled nanoformulation has demonstrated its potential for active drug delivery in pulmonary tuberculosis therapy.
Expression of AMT1;1 and AMT2;1 is stimulated by mineral nitrogen and reproductive growth stage in barley under field conditions

Abstract Barley (Hordeum vulgare) is an important cereal for providing food and feed. Nitrogen (N) is a crucial element for plant productivity. N fertilizing management requires large amount of money and energy, and excess application makes environmental hazards. Therefore, the future varieties and management systems need to be more efficient in nitrogen uptake and utilization. Ammonium transporters (AMTs) are important genes in N uptake and transport. Since N has strong impact on biomass production, it was hypothesized that N rate and barley growth stage have significant influence on AMT expression under field conditions. The field experiment was carried out in 2019 to determine expression patterns of HvAMT1;1 and HvAMT2;1 genes at different growth stages under different N fertilizer rates and types. A down-regulation of HvAMT1;1 and HvAMT2;1 until heading and up-regulation at anthesis stage was observed compared to the unfertilized treatment, mineral fertilizers having stronger effect. HvAMT1;1 was expressed 2.8 times more than HvAMT2;1 at the same time. There was a positive correlation between both AMT genes expression and N content in leaves at anthesis as well as 1000-kernel weight. In conclusion, nitrogen uptake and translocation is partially governed by HvAMT1;1 and HvAMT2;1, and it is a valuable candidate for breeding programs.
Potential and Viability of Stand Alone Solar PV Systems for Rural Electrification of Pakistan by using RET Screen Software

Pakistan is facing energy crisis from last decade in spite having huge potential of solar energy. This research work will provide an assessment of the solar potential of Khyber Pakhtunkhwa (K.P.K) region. A comparison of the economic and financial analysis(Net Present Value, Internal Rate of Return, Payback period, and simple payback period) for a stand-alone PV systems for different regions of K.P.K have been done by simulating the solar systems on RET Screen. RET Screen has also been used for studying the effects of slope, latitude, orientation and geographical conditions of the selected six sites of K.P.K. Also, environmental effects such as Greenhouse gas (GHG) emission have been calculated and finally an optimum location for the installation of the solar panels has been proposed based on the results of the RET Screen.
Worldwide Burden, Risk Factors, and Temporal Trends of Ovarian Cancer: A Global Study

Simple Summary Ovarian cancer was the third most common gynecological cancer globally in 2020. Ovarian carcinoma is the most common type of ovarian cancer, comprising over 90% of all ovarian cancer cases. The risk of ovarian cancer increases in females with age, along with having a family history, having a family cancer syndrome, and breast cancer susceptibility gene (BRCA) mutations. Investigation of the latest disease burden, risk factors, and temporal trends of ovarian cancer is important for the reduction of its associated mortality globally. The global incidence and mortality rates of ovarian cancer for 185 countries in 2020 were retrieved from the Global Cancer Observatory (GLOBOCAN) database established by the International Agency for Research on Cancer (IARC, WHO, Lyon, France). The incidence of ovarian cancer has been increasing substantially among younger females, probably caused by the increasing prevalence of obesity, metabolic syndrome, estrogen exposure and nulliparity. Abstract This study aimed to investigate the most updated worldwide incidence and mortality, risk factors, and epidemiologic trend of ovarian cancer in different countries, regions, and age groups. The Global Cancer Observatory database was used for incidence and mortality rates of ovarian cancer in 2020. Data from Cancer Incidence in Five Continents and the WHO mortality database was accessed for trend analysis. Age-standardized rates (ASRs, per 100,000 persons) were calculated for incidence and mortality. The 10-year annual average percent change (AAPC) was estimated by Joinpoint regression analysis. There was an overall decreasing trend of ovarian cancer, yet its burden has been increasing in lower-income countries and among younger females in some countries. Intensive lifestyle modifications are warranted, especially for the populations at high risk for ovarian cancer, including smoking cessation, alcohol use reduction, physical activity, weight control, and treatment of metabolic diseases.
Enhanced window breakdown threshold of the split‐horn antenna using an E‐plane field shaper

A compact split‐horn antenna with a high‐power handling capability to be able to radiate high‐power pulse energy through vacuum dielectric window into the free space without the occurrence of dielectric/air breakdown is proposed at S‐band. To increase the threshold of dielectric/air and vacuum/dielectric breakdown, it uses the special E‐plane field shaper at the edges of the split‐horn aperture. The proposed split‐horn antenna has a high‐power handling capability of 50 MW which is five times larger than that of the conventional split‐horn antenna of 10 MW for the air breakdown threshold of 30 kV cm−1 as well as a similar antenna gain and a radiation pattern. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:442–447, 2017
Topologies for three-element resonant converters

Many of the limitations of two-element resonant topologies can be overcome by adding a third reactive element. However, using three elements greatly increases the number of possible topologies, making it very difficult to explore this class of circuits on a trial-and-error basis. An orderly search procedure that exposes a large number of new topologies, many of which are resonant and have useful properties, is presented. >
PENGARUH ELECTRONIC WORD OF MOUTH (E-WOM) TERHADAP PURCHASE INTENTION PADA SMARTPHONE IPHONE DENGAN BRAND IMAGE SEBAGAI VARIABEL MEDIASI (STUDI PADA MAHASISWA DI KOTA MALANG)

Penulisan penelitian ini memiliki tujuan untuk mengetahui pengaruh electronic word of mouth (e-WOM) terhadap purchase intention pada smartphone iPhone di Kota Malang yang dimediasi oleh brand image, baik pengaruh secara langsung maupun tidak langsung. Jenis penelitian ini adalah explanatory research yang menjelaskan hubungan kausal antar variabel-variabelnya melalui pengujian hipotesis. Penelitian ini menggunakan sampel sebanyak 110 responden mahasiswa di Kota Malang yang belum pernah melakukan pembelian smartphone iPhone dengan menggunakan teknik non-probability sampling. Uji hipotesis dilakukan menggunakan uji t dan uji Sobel test. Analisis data menggunakan Partial Least Squares (PLS) dan dibantu oleh software SmartPLS 3.0 untuk memudahkan penelitian. Dari hasil pengujian terhadap keempat hipotesis yang telah dilakukan dapat disimpulkan bahwa variabel Electronic word of mouth berpengaruh positif dan signifikan terhadap brand image smartphone iPhone sebesar 0,585. Variabel electronic word of mouth berpengaruh positif dan signifikan terhadap purchase intention pada smartphone iPhone sebesar 0,243. Variabel brand image berpengaruh positif dan signifikan terhadap minat beli konsumen pada smartphone iPhone sebesar 0,576. Variabel electronic word of mouth berpengaruh positif dan signifikan terhadap purchase intention pada smartphone iPhone yang dimediasi oleh brand image sebesar 0,337. KATA KUNCI: Electronic Word of Mouth (E-WOM) , Brand Image, Purchase Intention .
Implementation of SMOTE and Under Sampling on Imbalanced Datasets for Predicting Company Bankruptcy

Kebangkrutan pada suatu perusahaan menjadi masalah yang serius karena dapat menyebabkan kerusakan ekonomi serta konsekuensi sosial lainnya. Sangat penting untuk melakukan prediksi kebangkrutan sedini mungkin karena prediksi ini dapat bermanfaat untuk evaluasi serta merencanakan tindakan pencegahan dalam menghindari kebangkrutan. Prediksi kebangkrutan merupakan salah satu permasalahan imbalanced classification karena data dengan kelas bangkrut jauh lebih sedikit daripada kelas tidak bangkrut. Penelitian ini bertujuan untuk menghasilkan model klasifikasi yang baik untuk melakukan prediksi kebangkrutan. Resampling diterapkan pada data latih agar menghasilkan model klasifikasi yang lebih optimal. Metode resampling yang digunakan adalah kombinasi SMOTE dan under sampling. Metode klasifikasi yang digunakan untuk prediksi adalah multilayer perceptron dan complement naïve bayes. Performa prediksi dihitung menggunakan skor recall, ROC AUC, dan PR AUC. Berdasarkan hasil pengujian, penggunaan SMOTE dan under sampling cukup signifikan dalam memperbaiki model klasifikasi pada multilayer perceptron. Pada prediksi menggunakan complement naïve bayes, nilai recall dan PR AUC juga meningkat. Recall terbaik yang diperoleh sebesar 95,45% dengan metode complement naïve bayes. Untuk ROC AUC tertinggi dengan resampling juga diperoleh menggunakan complement naïve bayes sebesar 87,80%. Oleh karena itu, disimpulkan bahwa prediksi kebangkrutan menggunakan teknik resampling yaitu SMOTE dan under sampling dapat menghasilkan performa baik untuk pendeteksian kelas bangkrut.
Improving dynamic response of PEMFC using SMES and bidirectional DC/DC converter

Nowadays, the use of renewable energy systems, especially fuel cells, has become very widespread in various applications. Some of their most important applications include using electric vehicles and local off-grid power systems. One of the challenges with the fuel cells is the slow dynamic response to load power changes. In fact, when the load power changes suddenly, the fuel cell supplies it with a time delay, and this can cause disturbances in the performance of the loads. In this research, a new control method for a bidirectional DC/DC converter equipped with a superconducting magnetic energy storage system (SMES) is presented to exchange the stored energy with the proton-exchange membrane fuel cell (PEMFC) in a high response dynamic to overcome the slow dynamic of the fuel cell feeding load. The appropriate validation of the proposed system is verified by simulation in the MATLAB SIMULINK environment. The results illustrate that the slow-response of PEMFC is improved appropriately.
Analysis and Design of RF Energy-Harvesting Systems With Impedance-Aware Rectifier Sizing

Because of the interaction between the internal blocks of an RF energy harvesting (RFEH) system, sizing a rectifier only for high power conversion efficiency (PCE) is insufficient for improving global power harvesting efficiency (PHE). This brief analyzes and sizes the rectifier by taking its input and output impedances into account with a two-port model that combines the rectifier AC and DC characteristics. The AC characteristic in this model is used for impedance-aware rectifier sizing. We target a low input-impedance rectifier for better impedance matching between the receiver antenna and the rectifier. The DC characteristic describes the rectifier power loss allocation and estimates its maximum power point. A proposed parasitic-aware matching network sizing methodology predicts the PHE is finally limited by Ohmic loss in the matching network at a low incident power level. For overcoming this limitation, this brief also analyzes the impact of multiple rectifier stages on RFEH with a high peak-to-average power ratio (high-PAPR) incident waveform for improving the PHE. We design an RFEH prototype with a sized 28nm CMOS two-stage cross-coupled rectifier. Measurement results show sensitivity as low as −28.3 dBm with a peak PHE of 31.1% at −16.5 dBm 2.45-GHz high-PAPR incident power. It has sufficient high output impedance to prevent reverse leakage without the need for an additional self-gating circuit.
Can Sea Bands® be Used to Mitigate Simulator Sickness?

A North American tier-one automotive supplier (TOAS) conducted a study in 2002 using a vehicle driving simulator to study simulator sickness. The goal of the study was to explore a mitigation technique to lessen the severity of simulator sickness symptoms for older participants using the FDA-approved Sea Bands® acupressure wrist bands. The study revealed that the acupressure wrist bands may be an effective method for managing simulator sickness among older participants.
In vitro evaluation of antioxidant activity and determination of total phenolic and flavonoids contents of ethanol-water extracts of Paeonia lactiflora and Calendula officinalis L. petals

In this study, the petals collected from peony hybrid Paeonia lactiflora "Bowl of beauty" and Calendula officinalis L. were extracted using ethanol-water mixture assisted with microwave and ultrasonic treatment. The isolation of Calendula officinalis L. essential oil was done by hydrodistillation as well. The total phenolic and flavonoids content in the extracts and oil were determined and their antioxidant activity was evaluated. The highest total phenolic content was found for the extracts of hybrid Paeonia lactiflora and Calendula officinalis L. obtained by ultrasound extraction (9.73 and 10.03 mg GA/mL RE, respectively), while the highest flavonoid content was obtained by microwave-assisted extraction (14.45 and 6.02 mg QE/mL RE, respectively). Antioxidant activity was assessed using standard antioxidant in vitro DPPH• and ABTS•+ assays. The highest antioxidant activity was obtained in DPPH• and ABTS•+ assay for the microwave-assisted extraction of hybrid Paeonia lactiflora (79% and 83%) and ultrasound-assisted extraction of Calendula officinalis L. (45% and 49%), respectively. In order to improve the antioxidative activity of both extract and essential oil the pectin films with gallic acid, using enzymatically assisted catalysis to attain covalent bonding to a carrier, were prepared. Optical microscopy and FTIR spectroscopy were used for the characterization of obtained materials. The films, with essential oil of Calendula officinalis L. and gallic acid, showed significantly increased percentage inhibition in DPPH• and ABTS•+ test (91% and 95%, respectively) after 10 minutes. The results, also, showed that all formulations of pectin biopolymer film, modified with gallic acid, can be successfully applied as a carrier for both types of ingredients.
Identifying Occult Metastase Ratio and the related Factors in Early Stage Oral cavity Carcinoma

ÖZ Objective: Management of clinical node-negative neck in early-stage oral cavity squamous cell carcinoma is still controversial. There are three main options to consider as watch-and-wait, elective neck dissection, and sentinel node biopsy. Method: Patients were grouped as clinical node-negative and pathologic node-negative (group 1) and clinical node-negative and pathologic node-positive (group 2). Factors thought to affect occult metastasis such as age, tumor diameter, tumor thickness, perineural invasion, lymphovascular invasion, and differentiation were investigated using the Mann-Whitney U test, the Chi-square test, and Fisher’s exact test. Results: From 27 eligible patients, there were 12 (44.4%) females and 15 (66.6%) males. Sixteen patients were evaluated in group 1 and 11 were evaluated in group 2. The mean age of the patients was 58.20±14.05 years. The occult metastasis rates were 34% and 51% for T1 and T2 tumors, respectively. The mean tumor diameter was 24.78±12.79 mm, and the mean tumor thickness was 11.37±7.62 mm. The difference in mean values of tumor thickness between the groups was significant (p=0.024), but age (p=0.622) and tumor diameter (p=0.443) were not significantly different. The ROC analysis cut-off values for age, tumor diameter, and tumor thickness were 60 years, 23 mm, and 9.5 mm, respectively. Tumor thickness and lymphovascular invasion were significantly different between the groups, but age, differentiation, clinical T stage, and perineural invasion were not different. Conclusion: The high rates of occult metastasis in our series imply that elective neck dissection seems a more appropriate choice for early-stage oral cavity squamous cell carcinoma rather than watch-and-wait.
Physical activity classification using a single triaxial accelerometer based on HMM

This study focuses on physical activity classification method using a single triaxial accelerometer attached on chest. With acceleration data acquired by a wearable wireless device, features are extracted using sliding window to describe different activity types. Hidden Markov Model (HMM) is used to recognize physical activity sequence. A modified Viterbi algorithm is used to find the optimal state sequence. The experimental results on 6 subjects have achieved an overall accuracy of 99.59% using our method, which is the best result so far.
A Comparative Survey of Energy Harvesting Techniques for Wireless Sensor Networks

In wireless sensor networks (WSNs), one of major hurdles is the limited battery power that is unable to meet long-term energy requirement. Energy harvesting, conversion of ambient energy into electrical energy, has therefore emerged as an effective alternative to powering WSNs. This paper surveys the most preferred ambient sources available for energy harvesting and the scavenging techniques commonly used in WSNs to deal with energy issues. Furthermore, the energy harvesting techniques are qualitatively compared, and challenges and open issues are discussed.
A STUDY ON THE PERFORMANCE OF IMPEDANCE MATCHING CIRCUIT IN PARTIAL DISCHARGE MEASURING SYSTEM

Partial discharge (PD) phenomena often result in serious faults in insulation. They may lead to electrical breakdown and cause loss of revenue to repair and replace the damaged part of the electrical equipment due to lack of precise and early detection of PD occurrence. PD measurements are important diagnostic tools to monitor the insulation condition of a device. Filtration in a PD measuring system is essential to eliminate or reduce noise pulses from affecting the measurement value. The device that is widely used nowadays is a high pass filter (HPF). In this project, an alternative filter device is established and studied, which is an impedance matching circuit (IMC). The aim of this project is to build an IMC in a PD measuring system for filtration purposes. The IMC is then measured to observe its characteristics and performance as a filter device in a PD measuring system. By measuring the number of PD occurrences and magnitude of PD on an insulation sample, the outcomes of PD obtained in the measurement system of impedance matching circuit are compared with those in high pass filter. From the tests, it was observed that IMC shows a smaller number of false PD occurrences and higher individual PD magnitude of each occurrence compared to HPF. Thus, the PD can be observed clearly even at smaller supply voltages by using IMC and breakdown of insulation can be avoided.