Miracle-dz/UniFAR-FTUs huggingface dataset:
Methodological Characteristics of Clinical Trials Supporting the Marketing Authorisation of Advanced Therapies in the European Union

Several advanced therapy medicinal products (ATMPs) have been approved in the European Union (EU). The aim of this study is to analyse the methodological features of the clinical trials (CT) that supported the marketing authorization (MA) of the approved ATMPs in the EU. A systematic review of the characteristics of pivotal CT of ATMPs approved in the EU until January 31st, 2021 was carried out. A total of 17 ATMPs were approved and 23 CT were conducted to support the MA (median, 1, range, 1–3). Of those studies, 8 (34.78%) were non-controlled and 7 (30.43%) used historical controls. Only 7 (30.4%) were placebo or active-controlled studies. Among all CT, 21 (91.3%) were open-label and 13 (56.52%) had a single-arm design. To evaluate the primary endpoint, 18 (78.26%) studies used an intermediate and single variable. The median (IQR) number of patients enrolled in the studies was 75 (22–118). To date, ATMPs’ approval in the EU is mainly supported by uncontrolled, single-arm pivotal CT. Although there is a trend toward an adaptive or a life cycle approach, a switch to more robust clinical trial designs is expected to better define the benefit and the therapeutic added value of ATMPs.
Development and Validation of Prediction Formula of Wingate Test Peak Power From Force–Velocity Test in Male Soccer Players

Peak power of the Wingate anaerobic test (WAnT), either in W (Ppeak) or in W.kg–1 (rPpeak), has been widely used to evaluate the performance of soccer players; however, its relationship with force–velocity (F-v) test (e.g., whether these tests can be used interchangeably) has received little scientific attention so far. The aim of this work was to develop and validate a prediction equation of Ppeak and rPpeak from F-v characteristics in male soccer players. Participants were 158 adult male soccer players (sport experience 11.4 ± 4.5 years, mean ± standard deviation, approximately five weekly training units, age 22.6 ± 3.9 years, body mass 74.8 ± 7.8 kg, and height 178.3 ± 7.8 cm) who performed both WAnT and F-v test. An experimental (EXP, n = 79) and a control group (CON, n = 79) were used for development and validation, respectively, of the prediction equation of Ppeak and rPpeak from F-v test. In EXP, Ppeak correlated very largely with body mass (r = 0.787), fat-free mass (r = 0.765), largely with maximal power of F-v test (Pmax; r = 0.639), body mass index (r = 0.603), height (r = 0.558), moderately with theoretical maximal force (F0; r = 0.481), percentage of body fat (r = 0.471), fat mass (r = 0.443, p < 0.001); rPpeak correlated with rPmax (largely; r = 0.596, p < 0.001), theoretical maximal velocity (v0; moderately; r = 0.341, p = 0.002), F0 (small magnitude; r = 0.280, p = 0.012), BF (r = −0.230, p = 0.042), and fat mass (r = −0.242, p = 0.032). Ppeak in EXP could be predicted using the formula “44.251 + 7.431 × body mass (kg) + 0.576 × Pmax (W) – 19.512 × F0” (R = 0.912, R2 = 0.833, standard error of estimate (SEE) = 42.616), and rPpeak from “3.148 + 0.218 × rPmax (W.kg–1) + v0 (rpm)” (R = 0.765, R2 = 0.585, SEE = 0.514). Applying these formulas in CON, no bias was observed between the actual and the predicted Ppeak (mean difference 2.5 ± 49.8 W; 95% CI, −8.7, 13.6; p = 0.661) and rPpeak (mean difference 0.05 ± 0.71 W.kg–1; 95% CI, −0.11, 0.21, p = 0.525). These findings provided indirect estimates of Ppeak of the WAnT, especially useful in periods when this test should not be applied considering the fatigue it causes; in this context, the F-v test can be considered as an alternative of exercise testing for estimating the average Ppeak of a group of soccer players rather than for predicting individual scores when the interindividual variation of performance is small.
A methodology for true comparison of analytical and measured frequency domain spectra in random PWM converters

The analysis of random PWM techniques has matured into a state where analytical expressions have been derived to aid in understanding the frequency domain characteristics. Derivations of the formulas require a lot of algebra, and the expressions must be verified by laboratory measurements. It is shown, however, that factors originating from digital signal processing techniques make the comparison difficult if proper measures against misinterpretation are not taken. A methodology to overcome the problems is presented. Novel expressions for the random lead-lag pulse position technique and the random switching frequency technique are also presented, as well as their verifications by laboratory measurements on a full-bridge DC/DC converter.
The Influence of Facial Asymmetry on Genuineness Judgment

This study investigates how asymmetry, expressed emotion, and sex of the expresser impact the perception of emotional facial expressions (EFEs) in terms of perceived genuineness. Thirty-five undergraduate women completed a task using chimeric stimuli with artificial human faces. They were required to judge whether the expressed emotion was genuinely felt. The results revealed that (a) symmetrical faces are judged as more genuine than asymmetrical faces and (b) EFEs’ decoding is modulated by complex interplays between emotion and sex of the expresser.
The Safety and Efficacy of Pregabalin Add-on Therapy in Restless Legs Syndrome Patients

Pregabalin is increasingly being used as a first-line treatment for symptomatic control of restless legs syndrome (RLS). This study aimed to evaluate the efficacy and safety of pregabalin as add-on therapy in RLS patients already taking dopamine agonists (DA) but still in need of further management. Patients with idiopathic RLS were enrolled, and all had already been prescribed DA for at least 3 months but still had either persistent symptoms, side effects, or comorbid insomnia. An initial dose of 75 mg pregabalin was begun, adjusted as needed, and maintained at a stable dose for 4 weeks, followed by observation for a total of 8 weeks. RLS symptoms and insomnia scores were evaluated before and after add-on pregabalin treatment. Patients were monitored for side effects that could be attributed to pregabalin. A total of 32 RLS patients were enrolled, and 20 subjects remained until the endpoint. After the pregabalin add-on, the mean IRLS score showed significant improvement compared to the baseline (p < 0.001). The insomnia severity index score also improved (p = 0.036), and no serious adverse effects were observed. Our preliminary data suggests the potential for pregabalin as an add-on therapy to DA with regards to both efficacy and safety in patients who have inadequate RLS improvement.
Univariable and Multivariable Two-Sample Mendelian Randomization Investigating the Effects of Leisure Sedentary Behaviors on the Risk of Lung Cancer

Background: Leisure sedentary behaviors (LSB) are widespread, and observational studies have provided emerging evidence that LSB play a role in the development of lung cancer (LC). However, the causal inference between LSB and LC remains unknown. Methods: We utilized univariable (UVMR) and multivariable two-sample Mendelian randomization (MVMR) analysis to disentangle the effects of LSB on the risk of LC. MR analysis was conducted with genetic variants from genome-wide association studies of LSB (408,815 persons from UK Biobank), containing 152 single-nucleotide polymorphisms (SNPs) for television (TV) watching, 37 SNPs for computer use, and four SNPs for driving, and LC from the International Lung Cancer Consortium (11,348 cases and 15,861 controls). Multiple sensitivity analyses were further performed to verify the causality. Results: UVMR demonstrated that genetically predisposed 1.5-h increase in LSB spent on watching TV increased the odds of LC by 90% [odds ratio (OR), 1.90; 95% confidence interval (CI), 1.44–2.50; p < 0.001]. Similar trends were observed for squamous cell lung cancer (OR, 1.97; 95%CI, 1.31–2.94; p = 0.0010) and lung adenocarcinoma (OR, 1.64; 95%CI 1.12–2.39; p = 0.0110). The causal effects remained significant after adjusting for education (OR, 1.97; 95%CI, 1.44–2.68; p < 0.001) and body mass index (OR, 1.86; 95%CI, 1.36–2.54; p < 0.001) through MVMR approach. No association was found between prolonged LSB spent on computer use and driving and LC risk. Genetically predisposed prolonged LSB was additionally correlated with smoking (OR, 1.557; 95%CI, 1.287–1.884; p < 0.001) and alcohol consumption (OR, 1.010; 95%CI, 1.004–1.016; p = 0.0016). Consistency of results across complementary sensitivity MR methods further strengthened the causality. Conclusion: Robust evidence was demonstrated for an independent, causal effect of LSB spent on watching TV in increasing the risk of LC. Further work is necessary to investigate the potential mechanisms.
How support mechanisms and intrinsic country-level characteristics affect the implementation of wind and solar energy projects in several countries of the EU? A panel data approach Master's Thesis

Electricity drives the world around us; unfortunately, most sources of electricity are fossil fuels with high CO2 emissions and low energy security factors. Renewable energy initiatives represent a solution for both of these issues and many more. This thesis focuses on the mechanisms driving renewable energy development and installation figures for wind and solar photovoltaic energy. It also examines a multitude of intrinsic country-level characteristics such as geographical location, wind and solar electricity generation potential, as well as support mechanisms and other factors to derive conclusions relevant to the problem statement. For the purposes of this research, twelve countries were randomly selected out of the EU-27 and data covering the years 2003-2010 was used. The methodology used was that of random effects estimation in order to capture the effects of time-invariable and slowly changing characteristics such as the propensity of a government and people to demand and consume renewable energy, social and cultural drivers, location, renewable energy generation potential, and so forth. A total of twelve different econometric models were created with a broad spectrum of issue coverage and results. The most important results of this thesis show that energy security plays a key role in wind installation figures as well as having an exit to the North Sea. Furthermore, priceand tax-based support mechanisms proved to be highly effective in the case of wind and photovoltaic installations respectively; while quantity-based policies were proven to have little effect. Interestingly, EU membership, and wind and solar generation potential do not seem to influence installation figures. The former could be explained by ineffectiveness of European directives as opposed to the natural propensity of countries to drive renewables development while the latter can be attributed to a heightened need to depoliticize decisions regarding location of newly installed capacity.
Recent Advances on Cell-Based Co-Culture Strategies for Prevascularization in Tissue Engineering

Currently, the fabrication of a functional vascular network to maintain the viability of engineered tissues is a major bottleneck in the way of developing a more advanced engineered construct. Inspired by vasculogenesis during the embryonic period, the in vitro prevascularization strategies have focused on optimizing communications and interactions of cells, biomaterial and culture conditions to develop a capillary-like network to tackle the aforementioned issue. Many of these studies employ a combination of endothelial lineage cells and supporting cells such as mesenchymal stem cells, fibroblasts, and perivascular cells to create a lumenized endothelial network. These supporting cells are necessary for the stabilization of the newly developed endothelial network. Moreover, to optimize endothelial network development without impairing biomechanical properties of scaffolds or differentiation of target tissue cells, several other factors, including target tissue, endothelial cell origins, the choice of supporting cell, culture condition, incorporated pro-angiogenic factors, and choice of biomaterial must be taken into account. The prevascularization method can also influence the endothelial lineage cell/supporting cell co-culture system to vascularize the bioengineered constructs. This review aims to investigate the recent advances on standard cells used in in vitro prevascularization methods, their co-culture systems, and conditions in which they form an organized and functional vascular network.
Early Assessment of Response to Radiofrequency Ablation With CT Perfusion Imaging in Rabbit VX2 Liver Tumor Model

Objectives To discriminate viable tumors from benign periablational enhancement (BPE) in early stage after radiofrequency ablation (RFA) is a major confounding problem. The goal of this study is to evaluate quantitative assessment and diagnostic value of CT perfusion between viable tumors and BPE after RFA in the rabbit liver VX2 tumor model, with pathological results as the standard. Methods Twenty-eight VX2 liver tumors were treated with RFA, on days 1, 3, 7, and 14, seven rabbits were randomly chosen for CT perfusion and performed pathology examinations immediately. The perfusion parameters along with the profile of time-density curves (TDCs) and pseudo-color images of the parameters were observed in both BPE and viable tumors, then compared with the pathology results. The perfusion parameters included blood flow (BF), blood volume (BV), time to peak (TTP), permeability (P), arterial liver perfusion (ALP), portal venous perfusion (PVP) and hepatic perfusion index (HPI). Results A total of 26/28 rabbits successfully underwent CT perfusion, while 6/26 lesions were confirmed to be viable tumors. The TDCs of BPE were mainly speed-up platform curves (15/26), while the viable tumors showed mainly speed-up speed-down (3/6) and speed-up platform (2/6) curves. The PVP values were significantly higher, and the HPI values were significantly lower for BPE at all time points than viable tumors (P < 0.05). Both of PVP value and HPI value have high efficiency for the differential diagnosis of the viable tumors and BPE at each time point. These characteristics of CT perfusion parameters were consistent with pathological changes. Conclusions The TDCs, PVP and HPI have the potential to indicate BPE and viable tumors effectively early after RFA treatment, the results were highly consistent with pathology. CT perfusion has advantages with great efficacy in monitoring the therapeutic effect early after RFA treatment.
Constructing a Teaching Presence Measurement Framework Based on the Community of Inquiry Theory

Given that there is no consensus on a framework for measuring presence in online teaching, this paper focuses on the construction of a reliable measurement framework of teaching presence based on the Community of Inquiry theory. In this study, 408 questionnaires were collected from college students who had online learning experience. Item analysis, exploratory factor analysis, and confirmatory factor analysis were used to analyze the results, which showed that the five-factor framework is in good agreement with the data. The confirmatory factor analysis also demonstrated a good model fit of the correlated five-factor teaching presence framework. Therefore, the teaching presence measurement framework consisting of design and organization, discourse facilitation, direct instruction, assessment, and technological support, can serve as an effective tool to support teaching presence measurement and to provide guidance for instructors’ online teaching.
Influence of Anemia on Postoperative Cognitive Function in Patients Undergo Hysteromyoma Surgery

Cognitive dysfunction is a common disease in aging population. This study aims to compare the influence of different degrees of anemia on the cognitive function of patients undergo hysteromyoma surgery. Sixty-one patients aged 18–60 years who underwent uterine fibroid surgery in the Second Affiliated Hospital of Shantou University Medical College from March 2019 to December 2020 were selected for this study. Patients were divided into three groups: group normal (Group N, patients have no anemia), group of mild anemia (Group Mi, patients have mild anemia) and group of moderate anemia (Group Mo, patients had moderate anemia). Combined spinal and epidural anesthesia were administered. Cognitive function tests were performed 1 day before the surgery and repeated at the 5th and 30th days after surgery. Peripheral venous blood samples from patients were collected before the surgery, right after surgery and at the 24th and 72nd hours after surgery. The contents of S-100β, IL-6, TNF-α and IL-1β in serum samples were determined by ELISA. It was found that there were no significant differences in general characteristics of patients among Group N, Group Mi and Group Mo (p > 0.05). Nine patients developed postoperative cognitive dysfunction after surgery, and the incidence was 14.75% (9/61). The incidence of postoperative cognitive dysfunction (POCD) was 40% in Group Mo, which was higher than that in Group N and Group Mi. The difference was statistically significant (p < 0.05). Inflammatory factors in patients with POCD were higher in post-surgery than before-surgery (p < 0.05), while there was no statistical significance in the difference of inflammatory factors of patients without POCD before and after surgery (p > 0.05). Taken together, this study suggested that moderate anemia could be a risk factor of POCD in patients undergoing hysteromyoma surgeries. This study will help surgeons developing measures for preventing the occurrence of POCD.
Study of potential of Wireless Internet Technologies in Manufacturing

The paper analyses the development of advanced and Internet manufacturing technologies and the possibility of Wireless Internet Manufacturing (WIM). It presents the fundamental conditions of WIM and the applications of Wireless Internet, WIM and Wi-Fi. Three different WIM models with important kernel technologies and their solutions are discussed at length. They are important references of the application of Wireless Internet Manufacturing.
Solanum Fruits: Phytochemicals, Bioaccessibility and Bioavailability, and Their Relationship With Their Health-Promoting Effects

The Solanum genus is the largest in the Solanaceae family containing around 2,000 species. There is a great number of edibles obtained from this genus, and globally, the most common are tomato (S. lycopersicum), potato (S. tuberosum), and eggplant (S. melongena). Other fruits are common in specific regions and countries, for instance, S. nigrum, S. torvum, S. betaceum, and S. stramonifolium. Various reports have shown that flavonoids, phenolic acids, alkaloids, saponins, and other molecules can be found in these plants. These molecules are associated with various health-promoting properties against many non-communicable diseases, the main causes of death globally. Nonetheless, the transformations of the structure of antioxidants caused by cooking methods and gastrointestinal digestion impact their potential benefits and must be considered. This review provides information about antioxidant compounds, their bioaccessibility and bioavailability, and their health-promoting effects. Bioaccessibility and bioavailability studies must be considered when evaluating the bioactive properties of health-promoting molecules like those from the Solanum genus.
Effect of harmonic suppression on the dual‐band bandpass filters using T‐shaped and Π‐shaped transmission lines

A novel design for T‐shaped and Π‐shaped transmission lines on dual‐band bandpass filters are proposed to efficiently suppress high‐frequency harmonic. The dual‐band can be designed using stepped‐impedance resonators. The harmonic suppression of the proposed dual‐band bandpass filter is extended to 12 GHz with a rejection level higher than −20 dB. The measured results concur with the full‐wave simulation results. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:547–551, 2015
New Epidermal-Growth-Factor-Related Insights Into the Pathogenesis of Multiple Sclerosis: Is It Also Epistemology?

Recent findings showing that epidermal growth factor (EGF) is significantly decreased in the cerebrospinal fluid (CSF) and spinal cord (SC) of living or deceased multiple sclerosis (MS) patients, and that its repeated administration to rodents with chemically- or virally-induced demyelination of the central nervous system (CNS) or experimental allergic encephalomyelitis (EAE) prevents demyelination and inflammatory reactions in the CNS, have led to a critical reassessment of the MS pathogenesis, partly because EGF is considered to have little or no role in immunology. EGF is the only myelinotrophic factor that has been tested in the CSF and spinal cord of MS patients, and it has been shown there is a good correspondence between liquid and tissue levels. This review: (a) briefly summarises the positive EGF effects on neural stem cells, oligodendrocyte cell lineage, and astrocytes in order to explain, at least in part, the biological basis of the myelin loss and remyelination failure in MS; and (b) after a short analysis of the evolution of the principle of cause-effect in the history of Western philosophy, highlights the lack of any experimental immune-, toxin-, or virus-mediated model that precisely reproduces the histopathological features and “clinical” symptoms of MS, thus underlining the inapplicability of Claude Bernard's crucial sequence of “observation, hypothesis, and hypothesis testing. ” This is followed by a discussion of most of the putative non-immunologically-linked points of MS pathogenesis (abnormalities in myelinotrophic factor CSF levels, oligodendrocytes (ODCs), astrocytes, extracellular matrix, and epigenetics) on the basis of Popper's falsification principle, and the suggestion that autoimmunity and phologosis reactions (surely the most devasting consequences of the disease) are probably the last links in a chain of events that trigger the reactions. As it is likely that there is a lack of other myelinotrophic growth factors because myelinogenesis is controlled by various CNS and extra-CNS growth factors and other molecules within and outside ODCs, further studies are needed to investigate the role of non-immunological molecules at the time of the onset of the disease. In the words of Galilei, the human mind should be prepared to understand what nature has created.