Miracle-dz/UniFAR-FTUs huggingface dataset:
Attachment of a Myoelectric Prosthesis After Transulnar Osseointegration Implantation

Case: This report discusses 2 successful cases of traumatic transulnar amputees who underwent osseointegration implantation. After surgery, a myoelectric prosthetic equipped with Coapt (Chicago, IL) recognition software was attached directly to the implant. Patients underwent training with pattern recognition software to learn to control the myoelectric prosthetic with the multiarticulating hand and wrist. Both implants osseointegrated without signs of loosening at the most recent follow-up of 18 months and 2 years, respectively. Prosthetic control gradually improved to allow activities of daily living. Conclusion: These cases demonstrate what can be achieved with interdisciplinary coordination between surgeons, prosthetists, and emerging technologies.
Brand Innovation and Sign Mobility of Slogans: An Analysis of Coke Slogans

This paper presents a theoretical reflection on the contemporary expressions of the brand, emphasizing the role of slogans as a means of upgrade and innovation of identity mark to examine the potential communicative slogans capacity. Methods and Design: Uses the shape and content approach to examine the potential communicative slogans capacity as a strategy to extend the possibilities of connecting people and product significantly with five independent categories on shape and content variables. Results and Discussions: By analysis Coca Cola slogans became evident that the mobility presented in the last ten years, with exchange recurring slogans because of the low plasticity of other expressions of the brand, for example, logotypes or packaging. Sign mobility of the slogans points to potency as an expressive element capable of providing constant updates without weakening the strength of the brand sign. Keywords: Brand expressions, Brand identity, Innovation, Slogan.
200 °C operation of semiconductor power devices

There is a growing need for commercial and military power electronics to operate above 175 °C. Changes in operating parameters at 200 °C have been measured for three devices, an NPN bipolar junction transistor (BJT), an N‐channel insulated gate bipolar transistor (IGBT), and a N‐channel metal‐oxide‐semiconductor field effect transistor (MOSFET). Using the results of these changes, a power supply for 200 °C operation has been built for lifetime tresting of the IGBT and N‐MOSFET.
Associations of Ultrasound LI-RADS Visualization Score With Examination-, Sonographer-, and Radiologist-Factors: Retrospective Assessment in Over 10,000 Examinations.

Background: When performing ultrasound (US) for hepatocellular carcinoma (HCC) screening, numerous factors may impair hepatic visualization, potentially lowering sensitivity. US LI-RADS includes a visualization score as a technical adequacy measure. Objective: To identify associations between examination-, sonographer-, and radiologist-level factors and the visualization score in liver US HCC screening. Methods: This retrospective study included 6598 patients (3979 men, 2619 women; mean age, 58 years) at risk for HCC who underwent a total of 10,589 liver US examinations performed by 91 sonographers and interpreted by 50 radiologists. Visualization scores (A: no or minimal limitations; B: moderate limitations; C: severe limitations) were extracted from clinical reports. Patient location [emergency department (ED), inpatient, outpatient], sonographer and radiologist liver US volumes during the study period (<50, 50-500, >500 examinations), and radiologist practice pattern (ultrasound, abdominal, community, interventional) were recorded. Associations with visualization scores were explored. Results: Frequencies of visualization scores were 71.5%, 24.2%, and 4.2% for A, B, and C, respectively. Scores varied significantly (p<.001) between examinations performed in ED patients (59.7%, 33.1%, and 7.2%), inpatients (59.7%, 33.1%, and 7.2%), and outpatients (76.9%, 20.3%, and 2.9%). Scores also varied significantly (p<.001) by sonographer volume (<50 examinations: 58.4%, 33.7%, and 7.9%; >500 examinations: 72.9%, 22.5%, and 4.6%); reader volume (<50 examinations: 62.9%, 29.9%, and 7.1%; >500 examinations: 67.3%, 28.0%, and 4.7%); and reader practice pattern (ultrasound: 74.5%, 21.3%, and 4.3%; abdominal: 67.0%, 28.1%, and 4.8%; community: 75.2%, 21.9%, and 2.9%; interventional: 68.5%, 24.1%, and 7.4%). In multivariable analysis, independent predictors of score C were patient location [ED/inpatient: odds ratio (OR)=2.62; p=<. 001] and sonographer volume (<50: OR=0.1.55; p=.01). Among sonographers performing >50 examinations, the percentage of outpatient examinations with score C ranged from 0.8% to 5.4%; 9/33 were above the upper 95% CI (3.2%). Conclusion: The US LI-RADS visualization score may identify factors impacting quality of HCC screening examinations and identify outlier sonographers in terms of poor examination quality. The approach also highlights potential systematic biases among radiologists in their quality assessment process. Clinical Impact: These findings may be applied to guide targeted quality improvement efforts and establish best practices and performance standards for screening programs.
Evaluation of Imminent Take-Over Requests With Real Automation on a Test Track

Objective Investigating take-over, driving, non-driving related task (NDRT) performance, and trust of conditionally automated vehicles (AVs) in critical transitions on a test track. Background Most experimental results addressing driver take-over were obtained in simulators. The presented experiment aimed at validating relevant findings while uncovering potential effects of motion cues and real risk. Method Twenty-two participants responded to four critical transitions on a test track. Non-driving related task modality (reading on a handheld device vs. auditory) and take-over timing (cognitive load) were varied on two levels. We evaluated take-over and NDRT performance as well as gaze behavior. Further, trust and workload were assessed with scales and interviews. Results Reaction times were significantly faster than in simulator studies. Further, reaction times were only barely affected by varying visual, physical, or cognitive load. Post-take-over control was significantly degraded with the handheld device. Experiencing the system reduced participants’ distrust, and distrusting participants monitored the system longer and more frequently. NDRTs on a handheld device resulted in more safety-critical situations. Conclusion The results confirm that take-over performance is mainly influenced by visual-cognitive load, while physical load did not significantly affect responses. Future take-over request (TOR) studies may investigate situation awareness and post-take-over control rather than reaction times only. Trust and distrust can be considered as different dimensions in AV research. Application Conditionally AVs should offer dedicated interfaces for NDRTs to provide an alternative to using nomadic devices. These interfaces should be designed in a way to maintain drivers’ situation awareness. Précis This paper presents a test track experiment addressing conditionally automated driving systems. Twenty-two participants responded to critical TORs, where we varied NDRT modality and take-over timing. In addition, we assessed trust and workload with standardized scales and interviews.
Pediatric hospital proximity to endovascular thrombectomy centers in the United States

Since the publication of five large randomized controlled trials in 2015, endovascular thrombectomy (EVT) has become the standard of care for adult patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO). However, AIS is also an important cause of mortality and long-term disability in children and teenagers.2– 4 Accordingly, there has been a trend toward offering adult interventions for AIS such as intravenous thrombolysis and EVT to pediatric patients.5–7 Since few pediatric hospitals currently have the necessary infrastructure and expertise to provide EVT in-house, pediatric access to EVT often relies on proximity to adult EVT centers. No studies to date characterize the proximity of pediatric hospitals to EVT centers. In this cross-sectional study, we quantify the travel time and distance by road and aerial routes between pediatric hospitals and their nearest certified EVT centers throughout the contiguous United States to determine the feasibility of transporting children to a nearby EVT center.
Nano‐enabled Tumor Systematic Energy Exhaustion via Zinc (II) Interference Mediated Glycolysis Inhibition and Specific GLUT1 Depletion

Despite the promise of tumor starvation therapies, they are often associated with nonspecific and incomplete energy blockade. Here, a novel paradigm of starvation therapy is proposed to synergize the “Zn2+ interference”‐mediated glycolysis inhibition and Zn2+‐activating GLUT1 (Glucose transporter 1) tumor specific depletion for systematic energy exhaustion. It is discovered that ZIF‐8 (zinc imidazolate metal–organic frameworks ) can induce abrupt intracellular Zn2+ elevation preferentially in melanoma cells, and then achieve effective glycolysis blockade through “Zn2+ interference”‐triggered decrease of NAD+ and inactivation of GAPDH, making it a powerful tumor energy nanoinhibitor. Meanwhile, Zn2+‐activating DNAzymes for specifically cleaving GLUT1 mRNA is designed. This DNAzyme can only be activated under intracellular Zn2+ overloading, and then directionally cut off glucose supply, which further restrains the adaptive up‐regulation of glycolytic flux after glycolysis inhibition in tumors. Afterward, DNAzymes are loaded in ZIF‐8 concurrently tethered by hyaluronic acid (HA), constructing a “nanoenabled energy interrupter ”. Such a rational design presents a preferential accumulation tendency to tumor sites due to the active CD44‐targeting mechanisms, specifically achieves remarkable systematic energy exhaustion in melanoma cells, and affords 80.8% in tumor growth suppression without systemic toxicity in vivo. This work verifies a fascinating therapeutic platform enabling ion interference‐inductive starvation strategy for effective tumor therapy.
Effectiveness of psychosocial interventions on the burden and quality of life of informal caregivers of hemodialysis patients: a systematic review

Abstract Purpose To systematically review the effectiveness of psychosocial interventions developed for informal caregivers of hemodialysis patients. Methods Relevant studies were identified through five electronic databases: PubMed, Scopus, Web of Science, ProQuest, and the CENTRAL. Randomized controlled trials (RCTs) and quasi-experimental studies describing interventions for informal caregivers of adult in-center hemodialysis patients (≥18 years old) were included and independently appraised by two reviewers using the Joanna Briggs Institute Statistics Assessment and Review Instruments critical appraisal checklists. Results Eleven articles evaluating eight intervention programs were included in this review, covering a total of 729 informal caregivers. Most studies implemented educational or psycho-educational interventions (n = 6). Psycho-educational interventions designed to promote caregivers’ ability to care and to cope with the caregiving role had positive effects on burden and/or quality of life. Psychological interventions also had large effects on reducing the burden over time. Conclusions There are still few interventions available to caregivers of hemodialysis patients. Psychosocial interventions showed great potential in improving the caregiver burden and quality of life. Further research with rigorous designs is needed to achieve stronger evidence on the extent of the current findings. Trial registration number CRD42021247916. Implications for rehabilitation Patients with end-stage renal disease (ESRD) undergoing in-center hemodialysis often require emotional and/or practical support from family members or friends. Research has consistently shown that informal caregivers of hemodialysis patients may experience significant burden and a negative impact on their quality of life as a result of their caregiving role during the disease trajectory. This review evidenced that intervention programs involving education and psychological strategies had large positive effects on reducing caregiver burden and improving quality of life. The findings provide valuable evidence to recommend the inclusion of psychosocial programs to family caregivers as part of comprehensive renal care.
ANALYSIS OF STAKEHOLDERS IN THE PIGEON PEA (CAJANUS CAJAN (L.) MILLSP.) VALUE CHAIN FOR DETERMINATION OF A HYBRID BREEDING AGENDA IN KENYA

Understanding market requirements for crop improvement is a prerequisite for a successful breeding programme. New pigeon pea varieties must possess the desired pre-and post-harvest traits as defined by stakeholders in the value chain. The purpose of this study was to examine the various stakeholders and their core functions in order to identify characteristics of the market preferred pigeon pea varieties to be considered in the hybrid breeding programme, and to understand constraints affecting development of the sector. The study was carried out in Machakos, Makueni, Mbeere and Nairobi districts in Kenya. Key informant survey, semi-structured questionnaire, analysis of secondary data and literature review were tools used in the study. The key stakeholders identified were farmers, traders/processors, International Crops Research Institute for the Semi-Arid Tropics, Kenya Agricultural Research Institute, Kenya Plant Health Inspectorate Services, and Ministry of Agriculture. Others were KARI Seed Unit, Leldet Ltd and financial intermediaries. Large, white seed and medium maturity varieties were important traits preferred by farmers and processors/exporters for both domestic and export markets. Domestic as well as export markets exist, but exploitation has been hampered by low grain volumes. The unavailability of quality seed in sufficient quantities of high yielding varieties were cited as the main factors negatively affecting pigeon pea production. Introduction and production of hybrids will attract private seed companies that will guarantee quality seed supply in sufficient quantities for commercialization.
Developmental Programming, Evolution, and Animal Welfare: A Case for Evolutionary Veterinary Science

ABSTRACT The conditions animals experience during the early developmental stages of their lives can have critical ongoing effects on their future health, welfare, and proper development. In this paper we draw on evolutionary theory to improve our understanding of the processes of developmental programming, particularly Predictive Adaptive Responses (PAR) that serve to match offspring phenotype with predicted future environmental conditions. When these predictions fail, a mismatch occurs between offspring phenotype and the environment, which can have long-lasting health and welfare effects. Examples include metabolic diseases resulting from maternal nutrition and behavioral changes from maternal stress. An understanding of these processes and their evolutionary origins will help in identifying and providing appropriate developmental conditions to optimize offspring welfare. This serves as an example of the benefits of using evolutionary thinking within veterinary science and we suggest that in the same way that evolutionary medicine has helped our understanding of human health, the implementation of evolutionary veterinary science (EvoVetSci) could be a useful way forward for research in animal health and welfare.
Krankheitsängste bei Epilepsiepatient*innen

Zusammenfassung Theoretischer Hintergrund Das Vorhandensein einer organischen Grunderkrankung erschwerte lange die Diagnostik von krankheitsbezogenen Ängsten. Untersuchungen zeigen, dass ein erheblicher Anteil somatisch Erkrankter unter beeinträchtigenden Krankheitsängsten leidet. Fragestellung Es wurden Epilepsiepatient*innen untersucht, für die bisher keine Daten zu Krankheitsängsten vorlagen. Methode 76 Epilepsiepatient*innen wurden hinsichtlich ihrer Belastung (Mini-SCL), den Ängsten vor einem Voranschreiten der Erkrankung (PA-F) sowie hypochondrischen Merkmalen (MIHT) untersucht. Ergebnis Epilepsiepatient*innen waren nicht belasteter und ängstlicher als Normstichproben, zugleich lagen bei 28% (Gesamtbelastung) bis 45% (Ängstlichkeit) der Befragten klinisch auffällige Werte vor. Im Vergleich zu anderen somatischen Diagnosegruppen waren Progredienzängste gering ausgeprägt. Hypochondrietypische Merkmale fanden sich bei 7% (perzeptuell) bis 13% (affektiv/behavioral) der Befragten. Schlussfolgerung Ein erhöhtes Bewusstsein für Krankheitsängste kann helfen, die Versorgung und Lebensqualität von Epilepsiepatient*innen zu verbessern.
Concentration of selected elements in the hair of Madagascar girls in relation to nutritional status and place of residence

Abstract Although the children malnutrition in Madagascar and the environmental pollution of this country has been widely discussed, there is no research on the differences in toxic elements accumulation in human body in dependence on nutritional status of Malagasy. Nine elements concentration (Al, As, Cd, Cr, Hg, Ni, Pb, Sn and Sb) was determined in scalp hair of 103 schoolgirls (8–15 years old), living in two areas: urban – close to Antananarivo (UR) and rural Berevo region (RU). Samples were analysed by an inductively coupled plasma optical emission spectrometer. The nutritional status was evaluated by Cole’s index. Underweight was related to higher accumulation of Al, Cd and Cr in the hair girls, and more common among girls living in RU than UR region (42 % v. 28 %). Two-factor ANOVA showed differences in the Al and Cr content in the girls’ hair depending both on their place of residence and nutritional status. This indicates additional consequence of malnutrition to the girls development and health.
Comparisons of vehicle stability controls based on 4WS, Brake, Brake-FAS and IMC techniques

This paper proposes three different kinds of vehicle stability control systems all based on internal model control (IMC) strategy which are 4WS (4 wheel steer: front- and rear-wheel active steer) IMC, Brake-FAS (brake and front-wheel active steer) IMC and Brake IMC, respectively. Inverse system method is introduced to solve the nonlinearity coupled with brake involved vehicle stability control systems. Based on an 11-DOF (degrees of freedom) Matlab/Simulink® vehicle model testified by CarSim7®, simulations combined with different driving manoeuvres and road surfaces are performed, and detailed comparisons and analyses are given based on simulation results.
Feigned ADHD Associated Cognitive Impairment: Utility of Integrating an Eye-tracker and the MOXO-dCPT

Objective: The current study assessed the utility of eye-movements measures, gathered while participants performed a commercially available Continuous Performance Test (CPT), to detect feigned ADHD-associated cognitive impairment. Method: Healthy simulators (n = 37), ADHD patients (n = 33), and healthy controls (n = 36) performed an eye-tracker integrated MOXO-dCPT and a stand-alone validity indicator. Results: Simulators gazed significantly longer at regions that were irrelevant for successful MOXO-dCPT performance compared to ADHD patients and healthy controls. This eye-movement measure, however, had lower sensitivity than traditional MOXO-dCPT indices. Discussion: Gaze direction measures, gathered while performing a CPT, show initial promise as validity indicators. Traditional CPT measures, however, are more sensitive and therefore offer a more promising path for the establishment of CPT-based validity indicators. The current study is an initial exploration of the issue and further evaluation of both theoretical and practical aspects is mandated.
A System for In Vitro Generation of Mature Murine Plasma Cells Uncovers Differential Blimp-1/Prdm1 Promoter Usage

Key Points A multistep in vitro culture system generates fully mature murine plasma cells. Initial stimuli establish unique gene expression profiles. The system enables detection of regulatory diversity in the expression of Blimp-1/Prdm1. Upon encounter with Ag, B cells undergo a sequential process of differentiation to become Ab-secreting plasma cells. Although the key drivers of differentiation have been identified, research has been limited by the lack of in vitro models recapitulating the full process for murine B cells. In this study, we describe methodology using BCR or TLR ligation to obtain plasma cells that are phenotypically mature, have exited cell cycle and express a gene signature concordant with long-lived plasma cells. Dependent on the initial stimuli, the transcriptomes also show variation including the enhanced expression of matrisome components after BCR stimulation, suggestive of unique functional properties for the resultant plasma cells. Moreover, using the new culture conditions we demonstrate that alternative promoter choice regulating the expression of the master transcription factor Blimp-1/Prdm1 can be observed; when the canonical B cell promoter for Prdm1 is deleted, differentiating B cells exhibit flexibility in the choice of promoter, dictated by the initiating stimulus, with preferential maintenance of expression following exposure to TLR ligation. Thus our system provides a readily tractable model for furthering our understanding of plasma cell biology.
Construction and verification of an intelligent measurement model for diabetic foot ulcer.

OBJECTIVES The measurement of diabetic foot ulcers is important for the success in diabetic foot ulcer management. At present, it lacks the accurate and convenient measurement tools in clinical. In recent years, artificial intelligence technology has demonstrated the potential application value in the field of image segmentation and recognition. This study aims to construct an intelligent measurement model of diabetic foot ulcers based on the deep learning method, and to conduct preliminary verification. METHODS The data of 1 042 diabetic foot ulcers clinical samples were collected. The ulcers and color areas were manually labeled, of which 782 were used as the training data set and 260 as the test data set. The Mask RCNN ulcer tissue color semantic segmentation and RetinaNet scale digital scale target detection were used to build a model. The training data set was input into the model and iterated. The test data set was used to verify the intelligent measurement model. RESULTS This study established an intelligent measurement model of diabetic foot ulcers based on deep learning. The mean average precision@. 5 intersection over union (mAP@.5IOU) of the color region segmentation in the training set and the test set were 87.9% and 63.9%, respectively; the mAP@. 5IOU of the ruler scale digital detection in the training set and the test set were 96.5% and 83.4%, respectively. Compared with the manual measurement result of the test sample, the average error of the intelligent measurement result was about 3 mm. CONCLUSIONS The intelligent measurement model has good accuracy and robustness in measuring the diabetic foot ulcers. Future research can further optimize the model with larger-scale data samples.
Compact wideband bandstop filter using embedded capacitor

A new type of compact bandstop filter (BSF) using embedded capacitor in LTCC substrate is presented in this letter.Stopband rejection depth and bandwidth can be controlled simply by the value of the capacitor, while good return loss is realized by adjusting the impedance of two open‐circuited stubs. Further, filter size is miniaturized by the meandered closed‐loop structure. A lossless transmission line model analysis is used to derive design equations. To validate the proposed topology, a BSF centered at 4.5 GHz with bandwidth of 70% is designed and built. The implementation area is 0.35 λg × 0.25 λg, where λg is the guided wavelength at the mid‐stopband frequency. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:1511–1514, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26848