Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative study of the physiological performance of two species of Atriplex
growing in the same ecological conditions

The naturally adapted salt - tolerant plants which are exposed to extreme environmental conditions in the arid and semi-arid regions around the Mediterranean basin possess morphological, anatomical, physiological and biochemical adaptation mechanisms to thrive on salt-affected soils. The aim of this study was to investigate the difference between anatomical structural and physiological adaptation mechanisms of Atriplex nummularia and Atriplex halimus in response to stress conditions. The results revealed that Atriplex halmius performed better under stress conditions than Atriplex nummularia. The important anatomical features of Atriplex nummularia and Atriplex halimus and other Atriplex spp. in relation to environmental stresses are the presence of vesiculated hairs on the leaf surface. Atriplex halmius had specific structural characteristics and different physiological mechanisms for adaption to environmental stresses. It showed a range of morphological and anatomical adaptive traits such as smaller leaf size, more succulent in stem and leaves, more development of vesicular hairs, more development of sclerenchymatic tissues in the hypodermis and in the cortex of the stem as well as in the vascular bundles and in-between the vascular bundles. Also, Atriplex halimus tended to accumulate more minerals (Na + , Cl - , P and Mn 2+ ), proline and soluble sugars such as stachyose, mannitol and xylose in high concentration in dry season, which may play role in osmotic adjustment, while Atriplex nummularia accumulated more carbohydrates, glucose, xylose, fructose, mannitol and ribose. This study showed the most important anatomical features and physiological mechanisms of plants that are more tolerant to environmental stresses and subjected to natural selection.
chHDAC11 mRNA Expression During Prenatal and Postnatal Chicken (Gallus gallus) Brain Development

Background: Histone deacetylation plays an essential role in transcriptional regulation of cell cycle progression and other evolutionary processes. Several results confirm the importance of the latest found HDAC11 gene to deacetylate histone core in neurons and their supportive cells in developing the vertebrate Central Nervous System (CNS). Objectives: This study investigates the HDAC11 potential role in early chicken CNS development by studying its mRNA expression profile which may have unique means in studying human subjects. Materials & Methods: Chicken HDAC11 RNAs were reverse transcribed to cDNAs, and the amount of chHDAC11 transcripts was measured by ΔCT mean calculation using the real-time quantitative PCR method. One-way ANOVA and Duncan’s analysis (SigmaStat software version 4.0) were used to test the statistical significance of the results. The levels of significance were set at P≤0.05. Quantitative data are presented as Mean±SD. Results: The amount of HDAC11 mRNAs gradually increases, at least 2-3 times, from as early as day 14 (E14/HH40) of prenatal cortex formation to day P0 (E20=HH45) and continue to increase to day 40 in both cortical and hippocampal regions of the postnatal chicken brain during development (*P≤0.05). HDAC11 mRNA is not only expressed in the postnatal cortex and hippocampi regions but also—for the first time—in the developing brain during the prenatal period. Conclusion: Our results show a possibly important role for the latest found HDAC11 conserved gene in the development of vertebrates’ embryonic brain, which in turn may have a significant impact on understanding human brain development.
Treatment Outcomes and Relative Dose Intensity of Chemotherapy in Slovene Patients With Advanced Hodgkin Lymphoma

This retrospective study was undertaken to investigate the association of relative dose intensity (RDI) with the outcome of Hodgkin lymphoma (HL) patients with advanced stage disease receiving ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) and escalated BEACOPP regimen (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone). A total of 114 HL patients treated between 2004 and 2013 were enrolled for evaluation. RDI calculations were based on a Hryniuk's model. The association of variables with overall survival (OS) and progression-free survival (PFS) was analysed using univariate and multivariate Cox proportional hazards models. The median age of patients was 39 years, majority of patients were males and had stage IV disease. Fifty-four patients received ABVD and 60 received BEACOPP chemotherapy with 24 and 4 deaths, respectively. Patients in BEACOPP group were significantly younger with lower Charlson comorbidity index (CCI) in comparison with ABVD group, making the comparison of groups impossible. In ABVD group, RDI was not significantly associated with OS (p=0.590) or PFS (p=0.354) in a multivariate model where age was controlled. The low number of events prevented the analysis in the BEACOPP group. Patients' age was strongly associated with both OS and PFS: all statistically significant predictors for OS and PFS from univariate analyses (chemotherapy regimen, CCI, RDI) lost its effect in multivariate analyses where age was controlled. Based on our observations, we can conclude that RDI is not associated with the OS or PFS after the age is controlled, neither in all patients combined nor in individual chemotherapy groups.
The Pricing Strategy with the Effect of Reference Dependence Under Monopolistic Competition

As the consumers searching for the goods, it is very likely for them to use the strategy that choosing the product of the large firm as the reference point and compare it with the other products in order to purchase the most satisfied one. In the real world the market competition is most likely to be Monopolistic competition. The proposing of model in this work is based on this phenomenon. Consequently, this paper raised questions: in which sense the reference dependence and loss aversion parameter affect the pricing strategy of the different firms. The work finds out the reference dependence can still affect the pricing of products either for the large and small firms under monopolistic market and its effect is shown a downward trend as consumers searching times increased. The producers can choose to adapt their pricing strategy to the result which have been discovered in this paper and reply to the consumer behaviors.
Evaluation of development of Apple Inc. stock price time series

The paper deals with the the development of a specific company’s stock price time series. The aim of the paper is to use the time series method for a detailed analysis and evaluation of the development of Apple Inc. stock prices. Daily data from 2000 to 2020, daily data from the period of the economic crisis between 2007 and 2009 and daily data from the Covid-19 pandemic period from March 2020 to the end of the same year are used. The data, from the period of 2000 - 2020 show a gradual increase in Apple’s stock prices. The most common factor leading to the increase in stock prices is the launch of a new product or service on the global market. On the contrary, the reason for the decline in stock prices is customer dissatisfaction, the excess of demand over supply, or the political situation. The analysis of time series for the period of the economic crisis points to the fact that thanks to the development, innovation and constant introduction of new products into the market, the company was not significantly affected by the crisis and neither were stock prices. Naturally, there were some fluctuations in prices, but at the end of 2009, the company even reached the highest stock prices in its history to date. The analysis of time series during the global pandemic of Covid-19 shows a steady rise in stock prices. Currently, the company sells more and more products and introduces new services that help us work, study or entertain ourselves in these difficult times, in the safety of our homes.
Toward an Integrative Model of Trust for Digital Emergency Communication

Digital technologies have become an integral enabler of communication during various phases of emergency management (EM). A crucial prerequisite of e � ective communication between authorities and the public during EM is the establishment of adequate mutual trust. Trust, however, is an elusive concept which is not easily translatable into technical settings. In this paper we propose an integrative model of trust in digital communication and show how such model can be advantageous in assessing and improving trust relations in context of EM. Our interdisciplinary model, which is based on ﬁndings from psychology, sociology and computer sciences provides an abstraction which not only seizes both subjective and objective as well as personal and non-personal, e.g., institutional or cultural, aspects of trust but at the same time is concrete enough to be applicable to real-life scenarios.
Spatio-temporal variability of carbon dioxide and methane emissions from a Mediterranean reservoir

Spatio-temporal variability of carbon dioxide and methane emissions from a Mediterranean Reservoir Freshwater reservoirs constitute a significant source of carbon dioxide (CO2) and methane (CH4) to the atmosphere, and a precise quantification of the magnitude of these greenhouse gas emission on an annual scale is required. This quantification must consider both temporal and spatial variability of reservoir carbon gas fluxes. In addition, it is relevant to reinforce research focusing on the emission of CO2 and CH4 in Mediterranean reservoirs. Here, we simultaneously measured CO2 fluxes and CH4 ebullitive and diffusive emissions in the riverine and lacustrine zones of a Mediterranean reservoir (El Gergal, Spain) throughout a complete year to quantify their magnitude, explore their spatial and temporal variability, and investigate the potential limnological and hydrological factors influencing gases emissions. Our results show that during the study year El Gergal riverine zone was a CO2 sink, while the lacustrine zone was a CO2 source. In addition, both areas were CH4 sources to the atmosphere. CO2 and CH4 fluxes in El Gergal showed a marked temporal variability, with significant differences between mixing and thermally stratified periods. CO2 emissions were significantly influenced by surface chlorophyll-a concentration and pH, suggesting the prevalent role of primary production as CO2 flux driver. CH4 emissions were influenced by hypolimnetic methane concentration and hydrological factors potentially affected by climate change, such as water renewal rate and
Analisis Pengaruh Belanja Iklan terhadap Kinerja Perusahaan dengan Corporate Social Responsibility sebagai Variabel Moderasi

Penelitian ini bertujuan untuk menganalisis pengaruh belanja iklan terhadap kinerja perusahaan yang diukur dengan penjualan dan profitabilitas perusahaan dengan pengungkapan Corporate Social Responsibility (CSR) sebagai variabel moderasi. Penelitian ini juga bertujuan untuk menganalisis pengaruh belanja iklan dan pengungkapan CSR terhadap kinerja perusahaan. Penelitian ini menggunakan data dari 40 perusahaan yang terdaftar di Bursa Efek Indonesia sektor Consumer Non-Cyclicals pada periode 2015 s.d. 2019. Penelitian ini merupakan penelitian kuantitatif dengan metode regresi linier berganda dengan menggunakan aplikasi STATA 16. Hasil dari penelitian ini menunjukkan bahwa belanja iklan berpengaruh positif dan signifikan terhadap penjualan perusahaan, namun tidak berpengaruh signifikan terhadap profitabilitas. Hasil dari penelitian ini juga menunjukkan bahwa CSR memoderasi secara tidak signifikan hubungan belanja iklan dengan kinerja perusahaan.
The Effect of Broccoli Extract in Arsenic-Induced Experimental Poisoning on the Hematological, Biochemical, and Electrophoretic Parameters of the Liver and Kidney of Rats

Heavy metals such as arsenic contribute to environmental pollution that can lead to systemic effects in various body organs. Some medicinal plants such as broccoli have been shown to reduce the harmful effects of these heavy metals. The main aim of the present study is to evaluate the effects of broccoli extract on liver and kidney toxicity, considering hematological and biochemical changes. The experimental study was performed in 28 days on 32 male Wistar rats classified into four groups: the control group (C), a group receiving 5 mg/kg oral arsenic (AS), a group receiving 300 mg/kg broccoli (B), and a group receiving arsenic and broccoli combination (AS + B). Finally, blood samples were taken to evaluate the hematological and biochemical parameters of the liver and kidney, as well as serum proteins' concentration. Liver and kidney tissue were fixed and stained by H&E and used for histopathological diagnosis. The results demonstrated a significant decrease in white blood cells (WBC), red blood cells (RBC), and hemoglobin (Hb) in the AS group compared to other groups. However, in the B group, a significant increase in RBC and WBC was observed compared to the AS and C groups (P < 0.05). Moreover, RBC and WBC levels increased significantly in the AS + B group compared to the AS group (P = 0.046). However, in the AS group, aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine levels increased, while total protein, albumin, and globulin decreased. This can be a result of liver and kidney damage, which was observed in the AS group. Furthermore, the increase in the concentration of albumin and globulin in the AS + B group was higher than that in the AS group. Infiltration of inflammatory cells and necrosis of the liver and kidney tissue in the pathological evaluation of the AS group were significantly higher than other groups. There was an increase in superoxide dismutases (SOD), glutathione peroxidase (GPx), and total antioxidant capacity (TAC); however, a decrease in malondialdehyde (MDA) concentration was seen in the AS + B group compared to the AS group. It seems that broccoli is highly effective at reducing liver and kidney damage and improving the hematological and biochemical factors in arsenic poisoning conditions.
Changing in the production of anticancer drugs (vinblastine and vincristine) in Catharanthus roseus (L.) G. Don by potassium and ascorbic acid treatments  

Catharanthus roseus seedling was treated with different concentrations (1.5, 3.16, 15, and 30 mmol) and forms (K<sub>2</sub>SO<sub>4</sub> and KNO<sub>3</sub>) of potassium (K<sup>+</sup>) via Hoagland’s nutrient solution. Ascorbic acid (AsA) was sprayed twice (plant days 68 and 78) with different concentrations (750 and 1 500 mg/L) on the leaves. Vinblastine, vincristine, tryptophan contents, D4H and DAT genes expression, peroxidase activity, and H<sub>2</sub>O<sub>2</sub> content of leaves were measured. Potassium in KNO<sub>3</sub> form increased vinblastine (60%) and vincristine (50%), compared to 30% and 20% using K<sub>2</sub>SO<sub>4</sub>. Vinblastine and vincristine inhibit microtubule assembly and ultimately metaphase-arrested caused by the polymerisation. The genes expression was higher 3 times in KNO<sub>3</sub> and 2.5 times in K<sub>2</sub>SO<sub>4</sub> in excess of K<sup>+</sup>. Foliar application of 750 mg/L AsA led to an increase in vinblastine (20%) and vincristine (16%). Both concentrations of AsA had the same additional effect on the expression of D4H and DAT about 30% and 60%, respectively, compared to the control plant. Tryptophan decreased 2.5 times in excess of K<sup>+</sup> and 35% due to the exterior of AsA. H<sub>2</sub>O<sub>2</sub> decreased while peroxidase activity increased along with AsA treatment. A positive interaction existed between the K<sup>+</sup> and AsA on the amount of vinblastine, vincristine, tryptophan, and gene expression.
Engineering-Economic Evaluation of Diffractive NLOS Backhaul (e3nb): A Techno-economic Model for 3D Wireless Backhaul Assessment

Developing ways to affordably deliver broadband connectivity is one of the major issues of our time. In challenging deployment locations with irregular terrain, traditional Clear-Line-Of-Sight (CLOS) wireless links can be uneconomical to deploy, as the number of required towers make infrastructure investment unviable. With new research focusing on developing wireless diffractive backhaul technologies to provide Non-Line-Of-Sight (NLOS) links, this paper evaluates the engineering-economic implications. A Three-Dimensional (3D) techno-economic assessment framework is developed, utilizing a combination of remote sensing and viewshed geospatial techniques, in order to quantify the impact of different wireless backhaul strategies. This framework is applied to assess both Clear-Line-Of-Sight and diffractive Non-Line-Of-Sight strategies for deployment in Peru, as well as the islands of Kalimantan and Papua, in Indonesia. The results find that a hybrid strategy combining the use of Clear-Line-Of-Sight and diffractive Non-Line-Of-Sight links produces a 9-45 percent cost-efficiency saving, relative to only using traditional Clear-Line-Of-Sight wireless backhaul links.
Application of IGCT of Large Power Transmitter in ELF Range

This paper introduces PA circuit of solid-state transmitter in Project WEM,and elaborates on IGCT's application in the ELF range in respects of components selection,gate interfacing,valve design,etc,based on brand-new electrical and electronic component selection as per circuit theories and their requirements,the selection of IGCT in particulars.
Conflict Management Styles of Middle-level Academic Administrators: Input to Conflict Development Plan

Conflict is endemic to all human and organizational life. It is an inevitable part on organization due to its related situations of division of functions, role disparity, power assertions and limited resources. Conflict arises when two individual or factions are disputing or opposing deliberately or unintentionally. Similar to other organizations, educational institutions are prone to relational conflict over several differences.Thomas-Kilman Conflict Mode Instrument guided this research study (Thomas and Kilman, 1974). The five styles of conflict management devised by Thomas and Kilman are indispensable in the realization of this study. To assess the preference of the middle-level administrators of the Bulacan State University on how to deal with conflicts, assertiveness and cooperation are two key parameters were used resulting to five diverse styles: avoiding, compromising, accommodating, competing and collaborating (optional must be supported by the survey result).
A Review on SLN and NLC for Management of Fungal Infections

Fungal disease is an invasive, serious, and systemic topical infection that affects the mucous membranes, tissues, and skin of humans. Oral medicines, on the other hand, have significant side effects, making topical treatments a viable alternative. Many antifungal medications applied through the skin in various conventional forms (gels or creams) may cause skin redness, erythema, stinging, and burning sensations. A promising approach to overcome the limitation of conventional form is the use of Nanocarriers for the treatment of skin infections since it allows targeted drug delivery, enhanced skin permeability, and controlled release and hence offers a lower risk of side effects. During the last few decades, lipid nanoparticles (LNPs) such as solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have gained a lot of attention. SLNs were designed to overcome the drawbacks of conventional colloidal carriers, such as emulsions, liposomes, and polymeric nanoparticles, by offering benefits such as a good release rate and drug targeting with high physical stability. NLCs are SLNs that have been modified (Second generation SLN) to improve stability and capacity loading. This review discusses the pathophysiology of the fungal diseases, the application of SLN and NLC, its method of preparation, Characterization, and an overview of clinical trials on SLN and NLC for the treatment of fungal infection.
Clinical characteristics of patients with acquired immunodeficiency syndrome having respiratory symptoms as the initial manifestations: A retrospective study

The aim of the study was to investigate clinical features of patients with AIDS having respiratory symptoms as initial manifestations and help in the early diagnosis. Eighty-eight patients admitted to the Shanghai Pulmonary Hospital were included in the study. General data, clinical manifestations, laboratory tests, chest computed tomography (CT) imaging features, treatments, and prognosis were analyzed. Peripheral leukopenia, lymphopenia, hypoxemia, and reduced percentage of CD4+ T lymphocytes were found in 25.6%, 43.6%, 27.5%, and 94.9% of the patients, respectively. Pneumocystis jirovecii pneumonia (PCP) was the most frequent cause of opportunistic pulmonary infection. Patients with PCP had more bilateral lung involvement and ground-glass shadow in CT manifestations. A follow-up of the 43 patients transferred to the Public Health Center showed improvement in 27 (62.8%), stabilization in 4 (9.3%), worsening in 1 (2.3%), and death in 11 (25.6%) patients. Detailed medical history recording, screening of human immunodeficiency virus antibody, and flow cytometry would improve the diagnostic efficiency of AIDS in patients with diffuse ground-glass shadow in chest CT. Early and empirical treatment could improve the prognosis.
Clinical trials and Consolidated Standards of Reporting Trials: Continuing concerns of compliance in COVID-19 era

COVID-19 g loba l pandemic ’s se r ious hea l th consequences created an urgent unmet medical need to discover effective therapies for managing disease and preventing complications. This has led to an exponential increase in clinical research publications related to COVID-19. PubMed lists 202,277 articles. The urgency of planning and the speed of publication have raised major concerns regarding the scientific rigor and quality of clinical research in COVID-19. [1,2] Jung et al. performed a systematic review to evaluate the methodological quality of 686 COVID-19 articles. Quality scores of methodology in COVID-19 articles were lower as compared to historical controls. [1] However, this study included only three randomized controlled trials (RCTs). PubMed includes 1424 clinical trials, and Clinitrials.gov has registered 1461 RCTs. As RCTs are gold standard for supporting evidence of efficacy of different interventions, it is imperative to assess quality of published RCTs on COVID-19.