Miracle-dz/UniFAR-FTUs huggingface dataset:
Antitumor and Antioxidant Effects of Flavonoid Fraction of Citrus sinensis peel Extract

Background: Cancer is one of the leading causes of death and globally the numbers of cases of cancer are increasing gradually. However, surgeries, chemotherapies have become safer, but these treatments have debilitating side effects. Flavonoids present in the human diet comprise many polyphenolic secondary metabolites with broad-spectrum pharmacological activities including their potential role as anti-cancer agents. Objective: The objective of the present study was to extract, orange peel flavonoids (Orange Peel Extract) and to screen anticancer potential of OPF. Methods: In the present study tryphan blue dye exclusion, clonogenic assay and nuclear damage studies by ethidium bromide staining were performed to estimate in vitro antitumor properties of Orange Peel Extract and subsequently in vivo studies also performed using the Dalton Lymphoma Ascites (DLA) tumor model in Swiss albino mice. Results: In vitro studies revealed the moderate toxicity, high regenerative capacity of Orange Peel Extract and also showed changes in nuclear morphology similar to that of apoptotic cells which is one of the important aspect of an anticancer drug. In vivo studies confirmed the anticancer activity of Orange Peel Extract and has increased the average life span of treated animals and restored the antioxidant enzyme levels and hematological parameters to normal which was comparable to that of standard methotrexate. Conclusion: Overall, these findings have proved that out of the two doses (50mg/kg bw and 200mg/kg bw) employed for the study lower dose (50mg/kg) was found to be more effective than higher dose (200mg/ kg). Hence flavonoid fraction of orange peels can be the better alternative to treat cancer.
A Review on an Efficient Ransomware Detection

: Cybersecurity shields the framework from unapproved access and obliteration of information. The expectation is to give security to the framework by blocking assailants. Malware or malignant programming is any sort of program which is created with the point of doing mischief to victim’s information. Viruses, worms, Trojan steeds, Ransomware, and spyware are various kinds of malware. At the point when pernicious programming goes into the framework, it will encode the client information, erases or changes the information. This kind of programming likewise used to take the client information. Ransomware is one of the kinds of malware that was created with the goal of getting cash from the victim. When Ransomware begins executing in our framework, it will begin encoding, erasing and changing documents. The client will get an unscrambling key simply subsequent to paying the guaranteed cash. Many have discovered a few solutions for recognizing some particular Ransomware. Ransom attacks can be forestalled by giving nearer consideration to application authorization demand and by utilizing anticipation systems. Avoidance methods can help distinguish and expel Ransomware without acquiring data about Ransomware. The focal point of the paper is on ransomware assaults on windows, android and different conditions. In windows ransomware, aggressors can be forestalled by checking unusual document framework and in android it tends to be identified by giving close consideration to the android manifest record.
Stability Improvement of Nitrogen Doping on IGO TFTs under Positive Gate Bias Stress and Hysteresis Test

Thin-ﬁlm transistors (TFTs) using indium-gallium-oxide (IGO) semiconductor materials as channel layers were fabricated. In this study, nitrogen was introduced in the process of channel deposition to investigate its effect on device performance. The experimental results showed that moderate nitrogen doping can signiﬁcantly improve the device stability under positive gate bias stress owing to the reduction of oxygen vacancies. Furthermore, for the purpose of understanding the inﬂuence of different doping levels, the nitrogen doping ratio was modulated in ascending order from 0 sccm to 5 sccm. Among the fabricated c-IGO TFTs, the one with 2 sccm nitrogen doping exhibited the least threshold voltage shift. In addition, the hysteresis measurement further conﬁrmed that the interface traps between the channel and the dielectric were signiﬁcantly passivated in nitrogen-doped TFT. In this regard, the method of in-situ nitrogen doping was certiﬁed to serve an efﬁcient way of fabricating a passivation-free TFT and improve the device stability simultaneously. © The
Performance‐Enhancing Selector via Symmetrical Multilayer Design

Two‐terminal selectors with high nonlinearity, based on bidirectional threshold switching (TS) behaviors, are considered as a crucial element of crossbar integration for emerging nonvolatile memory and neuromorphic network. Although great efforts have been made to obtain various selectors, existing selectors cannot fully satisfy the rigorous standard of assorted memristive elements and it is in great demand to enhance the performance. Here, a new type of Ag/TaOx/TaOy/TaOx/Ag (x < y) selector based on homogeneous trilayered oxides is developed to attain the required parameters including bidirectional TS operation, a large selectivity of ≈1010, a high compliance current up to 1 mA, and ultralow switching voltages under 0.2 V. Tunable operation voltages can be realized by modulating the thickness of inserted TaOy. All‐TaOx‐based integrated 1S1R (one selector and one memristor) cells, prepared completely by magnetron sputtering and no need of a middle electrode, exhibit a nonlinear feature, which is quite characteristic for the crossbar devices, avoiding undesired crosstalk current issues. The tantalum‐oxide‐based homojunctions offer high insulation, low ion mobility, and rich interfaces, which is responsible for the modulation of Ag conductive filaments and corresponding high‐performance cation‐based selector. These findings might advance practical implementation of two‐terminal selectors in emerging memories, especially resistive random access memories.
Effect of assembly pH and ionic strength of chitosan/casein multilayers on benzydamine hydrochloride release

Abstract Multilayer biopolyelectrolyte films are built from chitosan and casein by layer-by-layer deposition onto corona precharged poly(DL-lactic acid) substrate. Such structure allows optimization with respect to the morphology and ability of drug immobilization and release by changing the assembly conditions. Variation of chitosan and casein solutions ionic strength and chitosan solution pH at constant casein solution pH, effects significantly the polyelectrolyte multilayer structure and drug release. pH and ionic strength increase change the morphology from dense to loose, and the ionic strength increase let to screening effect and complexation of the drug, resulting in slow drug release. Graphical Abstract
Hydroxyapatite Nanoparticle Coating on Polymer for Constructing Effective Biointeractive Interfaces

Bone is an organic-inorganic composite with the ability to regenerate itself. Thus, several studies based on artificial organic-inorganic interface sciences have been tried to develop capable materials for effective regenerative bone tissues. Hydroxyapatite nanoparticles (HAp NPs) have extensively been researched in bone tissue engineering due to the compositional and shape similarity to the mineral bone and excellent biocompatibility. However, HAp alone has low mechanical strength, which limits its applications. Therefore, HAp NPs have been deposited on the biocompatible polymer matrix, obtaining composites with the enhanced mechanical, thermal, and rheological properties and with higher biocompatibility and bioactivity. For developing new biomedical applications, polymer-HAp interfacial interactions that provide biofusion should be investigated. This paper reviewed common coating techniques for obtaining HAp NPs/polymer fusion interfaces as well as in vitro studies of interfacial interactions with proteins and cells, demonstrating better biocompatibility. Studies based on interfacial interactions between biomolecules and HAp NPs were highlighted, and how these interactions can be affected by specific protein preadsorption was also summarized.
Lung‐Endothelium‐Targeted Nanoparticles Based on a pH‐Sensitive Lipid and the GALA Peptide Enable Robust Gene Silencing and the Regression of Metastatic Lung Cancer

The development of efficient gene delivery systems targeting the lung endothelium remains a serious challenge. This study reports on the design and optimization of a multifunctional envelope‐type nanodevice (MEND) for an efficient siRNA delivery to the lung endothelium based on GALA‐peptide targeting ability. The incorporation of a pH‐sensitive lipid (YSK05) results in a dramatic improvement in silencing efficiency by enhancing endosomal escape, but this also causes a reduction in the lung selectivity. Contrary to the assumption that active targeting is largely dependent on the presence of a targeting ligand, the findings of the present study indicate that nanocarrier composition is critical for achieving the organ selectivity. Interestingly, helper lipids substantially mask the liver delivery resulting in optimum lung targeting. The optimized YSK05‐MEND is 40‐fold more efficient than a previously developed MEND, with a robust lung endothelium gene knockdown at small doses. The YSK05‐MEND strongly inhibits a metastatic lung cancer model and exerts superior control over lung metastasis compared to chemotherapy or the previously developed MEND. The YSK05‐MEND is well‐tolerated in mice after acute or chronic administration. As far as it is known, YSK05‐MEND achieves the most efficient lung endothelium gene silencing reported thus far with a median effective dose of 0.01 mg siRNA kg−1 while minimally affecting the endothelium of other organs.
demand-withdraw pattern that is accompanied by anger and frustration, or a withdraw-withdraw pattern charac- terized by numbing and polarization, will expand into a more flexible pattern of expressing needs and vulnerabili-

empirically validated, and a recent meta-analysis found a considerable effect size for marital adjustment after 10–12 sessions ( Johnson, Hunsley, Greenberg, & Schlinder, 1999); there is research on the change process and predictors of success in this approach; finally, EFT has been applied to different kinds of problems and populations, such as the parents of chronically ill children (Walker, Johnson, Manion, & Clothier, 1996), depressed women (Dessaulles, 1991; Whiffen & Johnson, 1998), and couples dealing with posttraumatic stress disorder ( Johnson & Williams-Keeler, 1998). This approach is also used with families ( Johnson, 1996; Johnson, Maddeaux, & Blouin, 1998). The psychotherapy literature emphasizes that once general effectiveness has been established, the next challenge is to consider individual differences and specify how a treatment approach can be tailored to individual couples. There is as yet only one study that predicts success in EFT from initial client variables ( Johnson & Talitman, 1997). This article will attempt to summarize the empirical and theoretical underpinnings of EFT and then move on to consider how the clinical practice of EFT can be tailored to different kinds of partners at particular points in therapy. EFT focuses on reshaping a distressed couples structured, repetitive interaction patterns, and the emotional responses that evoke these patterns and fostering the development of a secure emotional bond ( Johnson, 1996, 1999). For example, in the process of therapy a repetitive demand-withdraw pattern that is accompanied by anger and frustration, or a withdraw-withdraw pattern characterized by numbing and polarization, will expand into a more flexible pattern of expressing needs and vulnerabiliThis article summarizes the theory, practice, and empir-
Oblivious communication game, self-testing of projective and nonprojective measurements, and certification of randomness

We provide an interesting two-party parity oblivious communication game whose success probability is solely determined by the Bell expression. The parity-oblivious condition in an operational quantum theory implies the preparation non-contextuality in an ontological model of it. We find that the aforementioned Bell expression has two upper bounds in an ontological model; the usual local bound and a non-trivial preparation non-contextual bound arising from the non-trivial parity-oblivious condition, which is smaller that the local bound. We first demonstrate the communication game when both Alice and Bob perform three measurements of dichotomic observables in their respective sites. The optimal quantum value of the Bell expression in this scenario enables us to device-independently self-test the maximally entangled state and trine-set of observables, three-outcome qubit positive-operator-valued-measures (POVMs) and 1.58 bit of local randomness. Further, we generalize the above communication game in that both Alice and Bob perform the same but arbitrary (odd) number ($n>3$) of measurements. Based on the optimal quantum value of the relevant Bell expression for any arbitrary $n$, we have also demonstrated device-independent self-testing of state and measurements.
Responses of residual and recommended N, P, K, S nutrients and crops to six annual soil test-based fertilizer rates and seeding systems

Abstract Responses of residual and recommended nitrogen (N), phosphorus (P), potassium (K), sulfur (S) nutrient amounts and crops (yield, emergence, and height) to 0, 60, 100, and 140% soil test-based fertilizer rate applications on the same plots for six years under minimum tillage and direct seeding systems were assessed. Higher fertilizer rates increased residual nitrate (NO3)-N, extractable K, and sulfate (SO4)-S amounts after a low crop yield year, particularly NO3-N, without temporal trend. Increase in residual available P level at higher fertilizer rates showed a positive temporal trend. Lower N, P, and S fertilizer rates were recommended to crops after higher residual NO3-N, available P, and SO4-S levels. Crops effectively used the residual nutrients. Compared to 0%, the relative seed yields at 60, 100, and 140% rates increased with years of fertilization. There were no clear responses of measured soil and crop parameters to seeding systems. Testing residual nutrients can optimize fertilizer use and crop yields.
On the Use of Online Reparametrization in Automated Platforms for Kinetic Model Identification

Parameter estimation algorithms integrated in automated platforms for kinetic model identification are required to solve two optimization problems: i) a parameter estimation problem given the available samples; ii) a model-based design of experiments problem to select the conditions for collecting future samples. These problems may be ill-posed, leading to numerical failures when optimization routines are applied. In this work, an approach of online reparametrization is introduced to enhance the robustness of model identification algorithms towards ill-posed parameter estimation problems. keywords: design of experiments, identification, model, online, robust parametrization
Chronic Kidney Disease and Major Risk Factors in Patients from Two Large Healthcare Systems: The CURE-CKD Registry

Author(s): Tuttle, Katherine; Alicic, Radica Z; Duru, O Kenrik; Jones, Cami R; Daratha, Kenn B; Nicholas, Susanne B; McPherson, Sterling M; Neumiller, Joshua J; Bell, Douglas S; Mangione, Carol M; Norris, Keith C
Effects of gonadal steroids on the expression of mucosal barrier system in the oviduct of hens

Mucosal barrier system formed by mucus layer, epithelial cell junctional structures, and leukocyte activity, play important role to prevent infection by microbes in mucosal tissue. Previous study reported that expression of mucin and tight junction-related molecules are changed during the molting phase compared with that in the laying phase. It is unique that many of the functions of oviduct are regulated by gonadal steroids, namely estrogen and progesterone. The aim of this study was to aprove of the effects of estrogen and progesterone on the expression of mucin and tight junction molecule claudins in the lower oviductal segments in hens.White Leghorn laying and molting hens were used. A proportion of the molting hens (n = 5 in each group) were injected with sesame oil (control), estrogen or progesterone. The lower segments of oviduct (isthmus, uterus, and vagina) of these birds were collected. Gene expression of mucin and claudin-1, -3, -5 was analyzed by quantitative reverse transcriptase polymerase chain reaction (RT-PCR). Localization of mucin5AC and claudin-1 protein was examined by immunohistochemistry. Localization of mucin polysaccharide was performed by alcian blue (AB) staining. In the lower oviductal segments, expression of mucin and claudin-1, -3, and -5 genes were up-regulated by both estrogen and progesterone. Immunoreactive mucin5AC and claudin-1 protein, as well as AB-positive mucopolysaccharidewasincreased by those gonadal steroids. These results suggest that gonadal steroids, estrogen and progesterone, may play a role to regulate mucosal barrier formed by mucin and tight junction molecule claudins at the lower oviductal segments. This mucosal barrier system in the oviduct is expected to play important roles to protect the oviductal tissues from infection by pathogenic microorganisms.
The Impact of General Agreement on Trade in Services For The Operation Of Foreign Banks In Indonesia

In Uruguay Round 1994, all participants committed to establish a multilateral framework of principles and rules for trade in services which was assumed as the proliferation of liberalization. It was comprehensively accepted as General Agreement on Trade in Services (GATS) that became inseparable part of World Trade Organization (WTO). They had hoped if GATS that entered into force in January 1, 1995, could remove any restrictions and internal governmental regulations in the area of services whose impact eventually emerged trade harassment. According to GATS, its substantial coverage encompassing bank as a legally binded sector in liberalization of trade in services. Indonesia agreed unanimously to be bound by GATS through promulgating Act 7 of 1994. Hence, the sui generis (specific) regulation of bank sector was revised which gradually allowed the operation of foreign banks in Indonesia. This paper attempts to identify and analyze meticulously what sort of impact arise from liberalization of bank service based on four modes of supplying services under article 1 of GATS encompassing cross-border supply, consumption abroad, commercial presence, and natural persons presence. In order to yield clear and objective explanation, its impact will be divided into positive impact and negative impact which significantly influenced the economic development in Indonesia.
Burgess, T.M. & Webster, R. 1980. Optimal interpolation and isarithmic mapping of soil properties. I. The semi‐variogram and punctual kriging. Journal of Soil Science, 31, 315–331

This landmark paper by Burgess & Webster (1980a) signalled a new era in the spatial mapping 2 of the soil. The emergence of pedometrics as a distinct subdiscipline of soil science was a gradual 3 process, and had its roots in earlier studies than this one, but if one publication is to mark the 4 start of pedometrics, then this is it. 5 The publication of this paper, and the successors in the series that it initiated, showed that 6 statistics could do more than just assist the soil surveyor in quantitative prediction from maps 7 based on a legend of discrete units. It showed soil scientists that there was a very different way 8 of mapping the soil, namely through geostatistical interpolation. 9 The impact of the paper on practice has been substantial. Soil scientists have used geosta10 tistical prediction to map the distribution of nutrients or pests at within-field scale for precision 11 agriculture, to delineate contaminated land, to map changes in soil properties over time at the 12 regional scale to map the risk of problems such as salinity and even for forensic inference. 13 The value of geostatistics was soon recognized in soil science. This is, in part, because when 14 one considers the state of the art at the time of its publication it is clear that it fulfilled a need for 15 new methods. At the same time, its impact was not simply due to the method it introduced to 16 soil science, ordinary kriging, but to the interest it stimulated among soil scientists and applied 17 statisticians who went on to develop and improve the methodology in several critical ways. 18
Effect of Velocity and Diffusion Functionality on Nonlinear Mass Transfer Mechanisms in Solvent Oil Recovery

Literature has indicated that, experimentally, solvent fronts in hybrid solvent recovery processes progress more rapidly than what can be predicted using current approximations and more rapidly than thermal processes alone. Research using finite differences to model the nonlinear advection, diffusion and dispersion (ADD) equation suggests that nonlinear mass transfer effects are important in predicting the rate of solvent advance. Nonlinearities can be ascribed to both diffusion and flow velocity functionality. Earlier work using linear concentration dependent diffusion and log-linear velocity behaviour confirmed the importance of nonlinear effects when compared to linear theory that uses constant diffusion, dispersion and velocity coefficients. The mathematical nature of the nonlinear ADD equation further suggests that the shape of concentration dependent diffusion and flow velocity will affect the shape of the solvent concentration profiles, and influence the rate of propagation of the solvent front. This research focuses on results obtained using finite differences to explore the effects of various diffusion and velocity functionalities that affect the solvent rate propagation using a nonlinear ADD equation. The results obtained from this analysis indicate that these functionalities determine the shape of the solvent concentration profile. The concentration dependent diffusion and velocity functions were chosen according to recent literature which proposes experimentally obtained functions to more accurately model solvent penetration in the media. Preliminary results from this study suggest that the velocity functionality has more influence on the process at both the lab and field scales for the parameters considered in this study. The shapes of the concentration profiles are affected by both diffusion functionality and velocity functionality.
Comparison of Enhanced Solubility Profile Analysis of Thermodynamic Parameters and Pharmacokinetic Profile Related to Tamoxifen Citrate Solubilisation

The aim of this study was to investigate the improvement of solubility of a poorly water soluble drug tamoxifen citrate (TC) by various methods such as cosolvency, micellisation, and complexation. Cosolvents (ethanol, polyethylene glycol-400), surfactants [polyoxyethylene sorbitan monooleate (Tween-80), poloxamer-407 and poloxamer-188], and cyclodextrins [β-cyclodextrin (BCD) and hydroxypropyl-β-cyclodextrin (HPBCD)] were used as solubilizing agents in this study. Solubility improvement approaches showed variable degrees of solubility improvement of TC. Among the solubilizing agents used, the modified β-cyclodextrin was found to be the most effective. The solubility of TC was enhanced to 6.31 mmolL -1 in water (about 7.1 fold solubility improvement) using 0.05% m/v hydroxy propyl-β-cyclodextrin. Different thermodynamic parameters, enthalpy and entropy, were analyzed for solubility enhancement of TC with different cyclodextrins which showed enthalpy not the entropy was the driving force for TC solubilisation. The less positive enthalpy of BCD complexation than HPBCD complexation signifies the higher solubilising efficacy of HPBCD. Pharmacokinetic study was performed using HPBCD as solubility enhancer at its optimized concentration which also resulted in improved bioavailability when compared to the bioavailability obtained with free tamoxifen.