Miracle-dz/UniFAR-FTUs huggingface dataset:
CD24-Fc suppression of immune related adverse events in a therapeutic cancer vaccine model of murine neuroblastoma

Introduction The combination of Myc-suppressed whole tumor cells with checkpoint inhibitors targeting CTLA-4 and PD-L1 generates a potent therapeutic cancer vaccine in a mouse neuroblastoma model. As immunotherapies translate from pre-clinical to clinical trials, the potential immune-related adverse events (irAEs) associated with induction of potent immunity must be addressed. The CD24-Siglec 10/G interaction is an innate checkpoint that abrogates inflammatory responses to molecules released by damaged cells, but its role in cancer immunology is not well defined. We investigate irAEs of an effective whole cell neuroblastoma vaccine and subsequently the effect of CD24-Fc, a CD24 and Fc fusion protein, on both the vaccine efficacy and induced irAEs in a mouse neuroblastoma model. Methods To test whether the whole tumor cell vaccination leads to autoimmune responses in other organ systems we harvested lung, heart, kidney and colon from naïve mice (n=3), unvaccinated tumor only mice (n=3), and vaccinated mice with CD24 Fc (n=12) or human IgG-Fc control (n=12) after tumor inoculation and vaccination therapy at day 30. The Immune cell infiltrates and immunogenic pathway signatures in different organ systems were investigated using NanoString Autoimmune Profiling arrays. Nanostring RNA transcript results were validated with immunohistochemistry staining. Results The whole tumor cell vaccine combined with immune checkpoint therapy triggers occult organ specific immune cell infiltrates, primarily in cardiac tissue and to a lesser extent in the renal and lung tissue, but not in the colon. CD24-Fc administration with vaccination partially impedes anti-tumor immunity but delaying CD24-Fc administration after initial vaccination reverses this effect. CD24-Fc treatment also ameliorates the autoimmune response induced by effective tumor vaccination in the heart. Discussion This study illustrates that the combination of Myc suppressed whole tumor cell vaccination with checkpoint inhibitors is an effective therapy, but occult immune infiltrates are induced in several organ systems in a mouse neuroblastoma model. The systemic administration of CD24-Fc suppresses autoimmune tissue responses, but appropriate timing of administration is critical for maintaining efficacy of the therapeutic vaccine.
Dual CSF1R inhibition and CD40 activation demonstrates anti-tumor activity in a 3D macrophage- HER2+ breast cancer spheroid model

The complex interaction between tumor-associated macrophages (TAMs) and tumor cells through soluble factors provides essential cues for breast cancer progression. TAMs-targeted therapies have shown promising clinical therapeutical potential against cancer progression. The molecular mechanisms underlying the response to TAMs-targeted therapies depends on complex dynamics of immune cross-talk and its understanding is still incomplete. In vitro models are helpful to decipher complex responses to combined immunotherapies. In this study, we established and characterized a 3D human macrophage-ER+ PR+ HER2+ breast cancer model, referred to as macrophage-tumor spheroid (MTS). Macrophages integrated within the MTS had a mixed M2/M1 phenotype, abrogated the anti-proliferative effect of trastuzumab on tumor cells, and responded to IFNγ with increased M1-like polarization. The targeted treatment of MTS with a combined CSF1R kinase inhibitor and an activating anti-CD40 antibody increased M2 over M1 phenotype (CD163+/CD86+ and CD206+/CD86+ ratio) in time, abrogated G2/M cell cycle phase transition of cancer cells, promoted the secretion of TNF-α and reduced cancer cell viability. In comparison, combined treatment in a 2D macrophage-cancer cell co-culture model reduced M2 over M1 phenotype and decreased cancer cell viability. Our work shows that this MTS model is responsive to TAMs-targeted therapies, and may be used to study the response of ER+ PR+ HER2+ breast cancer lines to novel TAM-targeting therapies.
Estimation of Gamma Dose in Neutron Dosimetry Using Peak 4 to Peak 5 Ratios in LiF:Mg, Ti (TLD-100/600)

This work investigates the possibility of extracting ancillary information from the TLD-100/600 glow curve, specifically, peak 4 to peak 5 ratios, as an aid to increasing the accuracy/reliability of the estimation of gamma dose in neutron dosimetry. Following irradiation in a pure gamma ray radiation field ( 60 Co) the intensity of peak 4 relative to that of peak 5 is 0.35 ± 0.05 (1 SD), whereas, irradiation by Am-Be neutrons results in a ratio of 0.13 ± 0.02 (1 SD) (air annealing). The accuracy of the evaluation of the neutron/gamma dose components (D,,, D g ) was investigated by separately irradiating polyethylene encapsulated TLD-600 chips by 60 Co gamma rays (D g ) and Am-Be neutrons (D,,) to known levels of dose between various values of D g /D (n+g) from 0.02 to 0.10. For these dose ratios, the accuracy of separation is excellent. Accurate separation of the dose components at higher values of D g relative to D n (>0.1) requires further development of the deconvolution technique to improve the reproducibility of the deconvolution of peaks 4 and 5.
Multiple uses of dexmedetomidine in small animals: a mini review

Dexmedetomidine is an alpha-2 adrenergic agonist, which use had an exponential increase in human and veterinary medicine in the last 10 years. The aim of this mini review is to summarize the various uses of dexmedetomidine underlining its new applications and capabilities in the small animals’ clinical activity. While this drug was born as sedative in veterinary medicine, some studies demonstrated to be effective as an analgesic both in single administration and in continuous infusion. Recent studies have also shown the role of dexmedetomidine as an adjuvant during locoregional anesthesia, increasing the duration of the sensitive block and consequently decreasing the demand for systemic analgesics. The various analgesic properties make dexmedetomidine an interesting drug for opioid-free analgesia. Some studies highlighted a potential neuroprotective, cardioprotective and vasculoprotective role of dexmedetomidine, thus conferring it a place in critical care medicine, such as trauma and septic patients. Dexmedetomidine has demonstrated to be a multitasking molecule and it is ready to face new challenges. Graphical Abstract
Analysis of transformations of the modern economy

The object of research is the economy, its types and directions of modern transformation in the conditions of global instability of world development in the 21st century. Since the economy is a reflection of the trends of social development, the understanding of the definition of «modern economy» changes and needs clarification and improvement. The active movement of resources and capacities as a result of global social upheavals of the 21st century has created a need to understand aspects of the migration economy. The research is analytical. During the research, special methods of information processing and analysis were used: elimination, intuitive method. The work is aimed at the systematization and generalization of the terminology used to characterize modern social production processes, determining the expediency of introducing the definition «migration economy». This will make it possible to formalize the process of making management decisions in the conditions of the trend of total migrations. The paper analyzes the terms that describe the economy at the current stage of development. It is shown that several terms are used simultaneously: «movement», «migration», «relocation». And only the term «migration» has an essential interpretation as emergency and unplanned actions. An attempt was made to formulate the definition of «migration economy» as a specific economic activity of society, caused by both voluntary and forced (including emergency) migration of subjects of economic relations across national or regional borders, which changes the spectrum of economic, social interactions and the economic landscape both in the territories of departure and in the territories of destination. The work shows that the real processes of the world economy require a modern terminological definition. This will form the basis for its forecasting and development. The interpretation of the modern economy as a migration economy allows for the formulation of new principles of the organization of production processes: autonomy, adaptability, allocation of business blocks according to the principle of optimal added value. The practical value of the work lies in the effort to form a definition of the modern economy, which makes it possible to specify management decisions on the organization of production and to understand the directions of changes.
Large-Scale Structure in the Universe Indicated by Galaxy Clusters

La facon dont la matiere est distribuee dans l'Univers, sous forme de galaxies ou d'amas de galaxies, est discutee a l'aide de techniques d'analyse statistique (fonction de correlation des amas) et de l'etude specifique des superamas et de leurs proprietes
Die Erwärmung in metallischen Kreislochscheiben bei radialem Heizstrom und temperaturabhängigem Leiterwiderstand

Mittels der Laplace-Transformation wird in der vorliegenden Arbeit im wesentlichen der Erwarmungsvorgang in einem Hohlzylinder berechnet, wenn u. a. die Erwarmung des Zylinders durch einen in radialer Richtung fliesenden elektrischen Strom erfolgt. Im Hinblick auf die kurze axiale Lange des Zylinders ist nur die Abhangigkeit der Temperatur von der radialen Koordinate ς von Belang. Da die Temperaturabhangigkeit des spezifischen elektrischen Widerstandes berucksichtigt wird, wird die transformierte Differentialgleichung des Erwarmungsvorganges inhomogen von der zweiten Ordnung, so das in der Losung neben den Zylinderfunktionen auch die Lommelsche Funktion auftritt. Der Parameter der Zylinderfunktionen wird rein imaginar, aber nur klein. Fur die Nullstellen der Koeffizienten-Determinante und fur die Zylinderfunktionen und die Lommelsche Funktion bei rein imaginarem Parameter werden Naherungsausdrucke angegeben. Using Laplace transformation, the paper calculates the heating in a hollow cylinder e. g. due to an electric current in radial direction. The axial length being small, it is only the dependence of temperature on the radial coordinate that matters. Since temperature dependence of electric resistivity is taken into account the transformed differential equation describing the heating process is inhomogeneous of second order; the solution, therefore, contains the Lommel function besides the Bessel functions. The parameter of the Bessel functions will be purely imaginary but small. Approximate expressions are found for the zeros of the determinant of the coefficients, as well as for the Bessel functions and the Lommel function for purely imaginary values of the parameter.
Prefetching Using Principles of Hippocampal-Neocortical Interaction

Memory prefetching improves performance across many systems layers. However, achieving high prefetch accuracy with low overhead is challenging, as memory hierarchies and application memory access patterns become more complicated. Furthermore, a prefetcher's ability to adapt to new access patterns as they emerge is becoming more crucial than ever. Recent work has demonstrated the use of deep learning techniques to improve prefetching accuracy, albeit with impractical compute and storage overheads. This paper suggests taking inspiration from the learning mechanisms and memory architecture of the human brain---specifically, the hippocampus and neocortex---to build resource-efficient, accurate, and adaptable prefetchers.
A novel three-step implicit iteration process for three (cid:12)nite family of asymptotically generalized (cid:8) -hemicontractive mapping in the intermediate sense

In this paper, we introduce a three-step composite implicit iteration process for approximating the common (cid:12)xed point of three uniformly continuous and asymptotically generalized (cid:8)-hemicontractive mappings in the intermediate sense. We prove that our proposed iteration process converges to the common (cid:12)xed point of three (cid:12)nite family of asymptotically generalized (cid:8)-hemicontractive mappings in the intermediate sense. Our results extends, improves and complements several known results in literature
TURBULENT FEATURES BENEATH BREAKING WAVES

INTRODUCTION The process of wave breaking is one of the most complex and difficult subjects in fluid mechanics and by far not been fully understood yet. Many results about laboratory investigations and numerical simulations concerning breaking waves have been presented in the past, e.g. Ting and Kirby (1996) or Lin and Liu (1998). However almost all of them concentrated on depth induced breaking when a wave approaches a beach. Harms and Schlurmann (2004) presented the results of PIV measurements under breaking transient wave packages. Due to the relatively coarse resolution of 1.598 x 1.598 mm per pixel, PIV data precluded the analysis of turbulence and only mass transport velocities have been investigated. To further complete the studies of breaking waves exceeding a critical steepness the current paper presents numerical simulations of the turbulent features beneath these waves using a 3DNavier-Stokes solver and the Volume-of-Fluid (VOF) method to account for the free surface.
68Ga-Pentixafor PET/MRI for Treatment Response Assessment in Mantle Cell Lymphoma

Purpose The aim of this study was to compare CXCR4 imaging with 68Ga-pentixafor PET to MRI for treatment response assessment in patients with mantle cell lymphoma (MCL). Patients and Methods Twenty-two posttreatment 68Ga-pentixafor PET/MRI scans of 16 patients (7 women and 9 men; mean age, 69.9 ± 7.9) with a total of 67 target lesions on baseline PET/MRI were analyzed. Rates of complete remission per lesion and per scan, according to MRI (based on lesion size) and 68Ga-pentixafor PET (based on SUV decrease to lower than liver and blood pool uptake), were compared using McNemar tests. The t tests and Pearson correlation coefficients (r) were used to compare rates of change in lesion diameter products (DPs) on MRI, and standardized uptake values (SUVmax, SUVmean) on PET, relative to baseline. Results At interim PET/MRI, 18/32 (56.3%) target lesions met CR criteria on 68Ga-pentixafor PET, and 16/32 (50.0%) lesions met size-based MRI criteria for CR (P = 0.63). At end-of-treatment PET/MRI, 40/57 (70.2%) target lesions met 68Ga-pentixafor PET criteria for CR, and 27/57 (47.4%) lesions met size-based MRI criteria for CR (P = 0.021). Complete remission after treatment was observed more frequently on 68Ga-pentixafor PET (11/22 scans, 54.5%) than on MRI (6/22 scans, 27.3%) (P = 0.031). Rates of change did not differ significantly between lesion DP (−69.20% ± 34.62%) and SUVmax (−64.59% ± 50.78%, P = 0.22), or DP and SUVmean (−60.15 ± 64.58, P = 0.064). Correlations were strong between DP and SUVmax (r = 0.71, P < 0.001) and DP and SUVmean (r = 0.73, P < 0.001). Conclusions In MCL patients, 68Ga-pentixafor PET may be superior for assessment of complete remission status than anatomic MRI using lesion size criteria, especially at the end of treatment.
Regression, Discrimination and Measurement Models for Ordered Categorical Variables

Regression models for the analysis of ordered categorical variables are discussed with particular reference to the logistic model. Maximum likelihood estimation procedures are established for three common sampling plans including the case where sampling is conditional on the ordered variable. This was previously not available. The use of these models in discrimination is discussed and an example given. An original method for the establishment of rating scales based on a coarse direct assessment and related variables is introduced. Mention is made of some difficulties in the application of the models and of their potential use for the analysis of designed experiments with ordered response variables.
Two-Sided Ideals and Congruences in the Ring of Bounded Operators in Hilbert Space

The developments of the present paper center around the observation that the ring B of bounded everywhere defined operators in Hilbert space contains non-trivial two-sided ideals. ' This fact, which has escaped all but oblique notice in the development of the theory of operators, is of course fundamental from the point of view of algebra and at the same time differentiates 93 sharply from the ring of all linear operators over a unitary space with finite dimension number. As examples of two-sided ideals in 93 we may mention here the class of all operators A such that J(A), the range of A, has a finite dimension number, the class of all operators of Hilbert-Schmidt type,2 and the class fT of all totally continuous operators. Except for the ideal (0), every two-sided ideal in 93 contains the first ideal mentioned, and except for the ideal J3 itself, every twosided ideal in 93 is contained in the ideal f. Moreover, on the basis of the special spectral properties of the self-adjoint members of sJ, it is possible to characterize every two-sided ideal in ? B very simply in terms of the spectra of its nonnegative self-adjoint elements; for both the formulation and the proof of this result, which together with the facts mentioned above is discussed in ? 1, the author is indebted to J. v. Neumann. The restriction of our attention to those ideals in if which are two-sided is basic for the points which we wish to develop; the two-sidedness compensates for the absence of commutativity in 93 in such a way as to permit the construction of quotient rings by the standard methods of abstract algebra.3 These rings, which are of course homomorphs of B with respect to addition and multiplication, are also homomorphs of. @ with respect to the operation *, and exhibit all of the formal properties of matrix algebras. This is established in ? 2, and there also various properties of the associated congruences in gB are discussed. The remainder of the paper deals solely with the quotient ring @/{, where fJ is the ideal of totally continuous operators, and the associated congruence in i3. For essentially topological reasons, this is the only one of the quotient rings in
Approximate and adaptive algorithms for some optimal motion-planning problems

Robotic motion planning involves computing collision-free paths or trajectories for a robot moving amid obstacles. It is one of the most fundamental problems in robotics research. This dissertation presents three major results on some motion-planning problems. Our first result is a novel approximation algorithm for the kinodynamic motion-planning problem. We consider the case of a point robot moving in a d-dimensional configuration space, with constrained dynamics. The constraints are given by upper-bounding the $L\sb2$ norms of the accelerations and velocities. Contrary to the previous approximation methods which use a uniform discretization in time space, our method employs a non-uniform discretization in configuration space (thus also a non-uniform one in time space). The discretization is coarser in regions that are farther away from any obstacles. The major consequence of such a discretization is a considerable decrease in the size of the search space, and in the running time, for many cases when the obstacles are sparse or are unevenly distributed. The second result is a faster approximation algorithm for the 2D curvature-constrained shortest-path problem. In the problem, the robot is a point moving in a plane whose path has a maximum curvature of 1, and the obstacles are polygons with a total of n vertices. The objective is to compute for the robot a shortest collision-free path that connects a given initial location and orientation to a final location and orientation. Compared to the previously best known result of Jacobs and Canny, the running time of our algorithm improves roughly from $O(n\sp3)$ to $O(n\sp2). $ More importantly, our running time does not depend on the total length of the obstacle edges, which can be arbitrarily large. Our third result is an optimal algorithm for an on-line navigation problem, the wall problem with penetrable obstacles. In the original wall problem of Blum et al., the point robot is to reach an oriented infinite line while moving amid oriented rectangular obstacles which are impenetrable. We generalize the obstacles to be penetrable and to have different weights. The objective is to minimize the weighted Euclidean distance.
Implementing A Novel Biometric Cryptosystem using Similarity Distance Measure Function Focusing on the Quantization Stage

Objectives: The essential requirement for a successful hashing method involves two distinct stages projection and quantization. In general, the projection stage is given much importance than the quantization stage. This stage has been concentrated in this paper which has equal importance as projection stage. Methods/Analysis: The using of Manhattan Distance method has been proposed in this paper instead of the widely used Hamming Distance, since it destroys the neighbourhood structure while measuring the similarity between points in the hashcode space. Findings: The problem of destroying the neighbourhood structure that existed in Hamming Distance is overcome by Manhattan hashing. Novelty/Improvement: The outperformance of Manhattan distance compared with Hamming distance has been shown and also, this paper has made an attempt to implement them in our Biocryptosystem to show its efficiency.
Analysis of Contact Force in Eddy-current System Using the Virtual Air-Gap Concept

It is difficult to calculate the magnetic force of an object of magnetic material in contact with other objects using the existing methods, such as Maxwell stress tensor method, magnetic charge method, or magnetizing current method. These methods are applicable for force computation only when the object is surrounded by air. The virtual air-gap concept has been proposed for calculating the contact force. However, its application is limited to magneto-static system. In this paper, we present the virtual air-gap concept for contact surface force in the eddy-current system. Its validity and usefulness are shown by comparison between numerical and experimental examples.
Switched adaptive stabilization of switched nonlinearly parameterized cascade systems and its application to a two inverted pendulums

This paper studies adaptive control of switched nonlinearly parameterized cascade systems. No solvability of the adaptive control problem for subsystems is required. By exploiting the multiple Lyapunov functions method and the parameter separation technique and the tool of adding a power integrator, we develop a new switched adaptive control approach for the explicit construction of adaptive controllers of subsystems and a proper switching law that solves the adaptive stabilization problem. A key feature of the proposed adaptive controllers is its switched property, namely, each subsystem has its individual update law. A two‐inverted pendulum as a practical example is also provided to demonstrate the effectiveness of the proposed design method. Copyright © 2014 John Wiley & Sons, Ltd.