Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecularly Targeted Therapy towards Genetic Alterations in Advanced Bladder Cancer

Simple Summary In recent years, there have been several advances in the care of advanced bladder cancer, highlighted by the addition of immune checkpoint inhibitors to the care of advanced disease. Despite these advances, there is a need for further improvement; the morbidity and mortality associated with advanced bladder cancer remain high. With the recent incorporation of advanced molecular techniques, there is more clarity regarding key genetic alterations of the disease. Therapies directed at specific genetic aberrations in bladder cancer provide both proven and potential paths forward. This review discusses the key targetable genetic aberrations and summarizes the current status of targeted therapies in muscle-invasive bladder cancer. Abstract Despite the introduction of immune checkpoint inhibitors and antibody–drug conjugates to the management of advanced urothelial carcinoma, the disease is generally incurable. The increasing incorporation of next-generation sequencing of tumor tissue into the characterization of bladder cancer has led to a better understanding of the somatic genetic aberrations potentially involved in its pathogenesis. Genetic alterations have been observed in kinases, such as FGFRs, ErbBs, PI3K/Akt/mTOR, and Ras-MAPK, and genetic alterations in critical cellular processes, such as chromatin remodeling, cell cycle regulation, and DNA damage repair. However, activating mutations or fusions of FGFR2 and FGFR3 remains the only validated therapeutically actionable alteration, with erdafitinib as the only targeted agent currently approved for this group. Bladder cancer is characterized by genomic heterogeneity and a high tumor mutation burden. This review highlights the potential relevance of aberrations and discusses the current status of targeted therapies directed at them.
Can I Sleep Safely in My Smarthome? A Novel Framework on Automating Dynamic Risk Assessment in IoT Environments

Fully automated homes, equipped with the latest iot devices, aiming to drastically improve the quality of lives of those inhabiting such homes, is it not a perfect setting for cyber threats? More than that, this is a fear of many regular citizens and a trending topic for researchers to apply cti for seamless cyber security. This paper focuses on the ra methodology for smarthome environments, targeting to include all types of iot devices. Unfortunately, existing approaches mostly focus on the manual or periodic formal ra, or individual device-specific cyber security solutions. This paper presents a draf, aiming to automate the identification of ongoing attacks and the evaluation of the likelihood of associated risks. Moreover, draf dynamically proposes mitigation strategies when full automation of the decision making is not possible. The theoretical model of draf was implemented and tested in smarthome testbeds deployed in several European countries. The resulting data indicate strong promises for the automation of decision making to control the tightly coupled balance between cyber security and privacy compromise in terms of the embedded services’ usability, end-users’ expectations and their level of cyber concerns.
Interventions to Prevent Readmissions in Hospitalized Peripheral Vascular Surgery Patients: A Systematic Review

A large proportion of peripheral vascular patients worldwide experience unplanned hospital readmissions after inpatient vascular surgery. This review was conducted to identify acute care and post-discharge interventions that may help in reducing unplanned vascular surgery readmissions. A computer-based search of four databases was conducted July 2021 for original research reports published 2000 to 2021. Eight studies met inclusion criteria, with interventions including multidisciplinary care teams, advance practice provider discharge coordination, individualized case management, home care nursing, early primary care provider or telephone follow-up, and telehealth driven follow up evaluated. Some reductions in readmission rates were associated with most interventions but were inconsistent across studies. Further research is necessary to clarify and validate these findings, incorporate patient perspectives, and explore the role of technology-based interventions. This work is key to improving the patient’s experience, reduce healthcare costs, and strengthen the quality of vascular surgery care.
Identification of novel microcephaly-linked protein ABBA that mediates cortical progenitor cell division and corticogenesis through NEDD9-RhoA

The cerebral cortex is responsible for higher cognitive functions. Its correct development depends on coordinated asymmetric division cycles by polarized radial glial progenitor cells. Mitotic defects in neuronal stem cells are linked to the aetiology of microcephaly, but the underlying mechanisms remain incompletely understood. Here we describe a novel role of the membrane deforming cytoskeletal regulator protein Abba (MTSS1L/MTSS2) in cortical development. Loss of Abba in the developing brain resulted in radial glia proliferation arrest, disorganized radial fibers and abnormal migration of neuronal progenitors. During cell division, Abba localized to the cleavage furrow where it recruited the scaffolding protein Nedd9 and positively regulated RhoA activity. Importantly, we identified a human variant Abba (R671W) in a patient with microcephaly and intellectual disability. Ectopic expression of this mutant protein in mice phenocopied Abba knockdown. Taken together, these data provide novel mechanistic insight into human microcephaly and cortical development by identifying ABBA as a novel regulator of faithful mitotic progression of neuronal progenitor cells.
The Implementation of English Medium Instruction (EMI) for Economics Students in Bilingual Class: Challenges and Solutions

Several studies have argued that learning a foreign language has the potential to increase the general cognitive ability of students who are from non-English departments. There is a tendency that in a bilingual program, these students obtained better achievements than those in monolingual programs. The purpose of this paper is to investigate the effectiveness of bilingual teaching of Economics students using English to teach content subjects. We would like to propose a model in which English Medium Instruction (EMI) implementation can be achieved by adopting it in the Faculty of Economics. The model examines the driving forces behind the implementation of EMI and analyses the implications and consequences of such instruction for Economics students. The result of this study revealed that the problems faced by Economics students in using English were related to speaking and writing skills. Employing social and academic language functions are found crucial for them who will become teachers of Economics after finishing their study. Finally, it is suggested that in order to implement the innovative EMI in teaching Economics, mixed-mode teaching in the classroom could be formed for subjects across the curriculum.
Effect of various temperature and storage time during process on physical quality and water-holding capacity of broiler breast meats

Water holding capacity ofchicken meat is very important for meat quality and meat production yield. Various conditions in product line might affect on quality and water holding capacity of chicken meat. The objective of this study was to determine the effect of process temperature, storage temperature and time and freeze-thaw process on quality ofbroiler breast meat. Higher process temperature inflenced on more lightness (L*), redness (a*), yellowness (b*) and drip loss in breast meat. However, no difference in cooking loss was observed among processing temperature (0-4oC, 8-10oC and 12-15oC for 8 hr). Broiler breast meat chilled at 12-15oCfor72hrhadhigher(P<0.05)inL*, b* and drip loss than thosechilledat 0-4o C. Longerchillingstorage time induced lower L*, a*, shear force value and greater b*, drip and cooking losses. Quality ofbroiler breast meat afterdelay time process at 0-4oC and 12-15oC for 24 h were studied comparatively between freeze-thawed and chilled sample. Freeze-thaw broiler meat had lower (P < 0.05) in L* and a* than those of chilled meat. Freeze-thaw process providedthe greaterdrip loss andlowershearforce in broilerbreastmeat.
Investigation of Inclusion States of Silicate and Carbonate Ions in Hydroxyapatite Particles Prepared under the Presence of Sodium Silicate

Biological hydroxyapatite (HA) contains the different minor ions which favour its bio-reactivity in vivo. In this study, the preparation of HA particles containing both silicate and carbonate ions under the presence of sodium silicate was investigated, and the physicochemical properties were evaluated according to the contents and states of silicate and carbonate ions. The increment in the silicate ion reduced the crystallinity and expanded the crystalline size along with a-axis. Solid-state 29Si–NMR spectra indicated the increase in the adsorption of oligomeric silicate species on the HA particle surfaces in addition to the substitution state of silicate ions, suggesting the occurrence of the surface coating of silicates on the surfaces. The possible states of carbonate and silicate ions at the HA surfaces will provide the bioactivity.
Effectiveness of Nurse-led Intervention to Improve Quality of life for Family Caregivers of Children with Leukemia: A Quasi-Experimental Study from Karachi Pakistan

Background: Acute lymphoblastic leukemia accounts for 25% of all cancers in children less than 15 years old. The treatment phase of leukemia is lengthy and takes 2-3 years. Due to prolonged treatment, family caregivers often become exhausted, highly distressed with low quality of life and unsatisfactory patient outcomes. Thus, caregivers need interventions such as adaptation strategies and access to support groups that enhance their wellbeing and improves their quality of life (QoL). Objectives: To determine the effectiveness of nurse-led structured educational intervention for family caregivers having a child diagnosed with leukemia and to examine the association between socio-demographic variables and quality of life of leukemia child caregiver. Methodology: A Quasi-Experimental pre-post-test design was applied at the tertiary care hospital of Karachi. A total of 74 family caregivers of leukemia children were recruited from outpatient and inpatient oncology departments using purposive sampling. The data was collected pre-intervention and post-intervention using QoL-FV. Intervention of educational session given in 30-45 minutes for 4 days and after 1month of intervention, posttest done by same questionnaire to estimate the effect of nurse-led education Results: Study findings revealed that mean score of overall QoL improved after one-month of nurse-led educational intervention 95+ 23 and had a significant difference in post-test QOL (<0.001). The sub-dimensions of QoL such as physical wellbeing, psychological wellbeing, and social concern improved significantly in posttest interventions group (P< 0.01). Whereas the spiritual wellbeing was found insignificant after interventions (p>0.080). Conclusion: The study suggests that Nurse-Led education program is helpful to improve family caregivers' quality of life during the treatment journey of their leukemia patient. it must be considered and acknowledged with prime importance and caregivers should be supported by health care professionals. Recommendation: It should be an important aspect to include counseling sessions of families to improve their coping, problem solving and awareness.
Intra‐Annual Variation of High and Low‐Flow Extremes Associated With Land Use and Climate Change in the Upper Tekeze of the Nile River Basin

In northern Ethiopian highlands, climate variability and land use/land cover (LULC) change has been observed during the past decades. However, it remains unclear that to which extent and how these key drivers contributed to changes in hydrological extremes. As a case study, the respective impacts of LULC change and climate variability on hydrological extremes with respect to magnitude, duration, and frequency metrics were assessed in the Upper Tekeze basin, Ethiopia. A scenario‐based approach using LULC and hydro‐climatological data was developed and five simulation experiments were conducted using Soil and Water Assessment Tool model. Results showed that, during 1986–2015, low‐flow duration has decreased by 5.0 days/yr, and the magnitude and occurrence of high flow has increased by 5.23 m3/s/yr and 5.11 days/yr, respectively. Meanwhile, about 47.42% of the landscape has changed its category while no significant change was detected in annual rainfall during the past 31 yr. Particularly, rocky area increased by 82% which was mostly contributed by losses of bare, sand, and low biomass areas. Significant positive and negative contributions to the changes in high and low‐flow extremes, respectively, were detected from LULC change, while no significant contribution was detected from climate change. The increased rock area tends to be one of the major contributors to the increased high flow while climate change seemed to play a minor role. The potential mechanism is the expansion in rock area increased runoff and high flow, which may lead to significant land deterioration and loss of water storage capacity in the mountainous basin.
Effect of Enzymatic Extraction Method on Quality Parameters and Sensory Acceptability of Date Dibs Produced from Second Grade Dates

This study was conducted to investigate the effect of enzyme extraction methods on quality parameters of dibs (date syrup) produced from the two varieties of second grade dates. Different concentrations of cellulase enzyme 0.5 and 1.0% were used. The efficiency of date dibs extraction prepared from siwi and sakkoty date (water : pulp) in proportions (2:1, 3:1 and 4:1) was done. The physicochemical and phytochemical characteristics of dibs were performed. The results showed non-significant differences between both variety from total and reducing sugars contents. Sakkoty date was characterized by significantly higher amount from crude fat, total carbohydrate, total flavonoids and antioxidants contents, while siwi date contained significantly higher amounts from moisture and total acidity contents. There were no significant differences between both date varieties in the content of total phenolic compounds. Enzyme extraction methods showed an increase in total sugar content and the total sugar percentage increased with the increasing in the enzyme percentage at the same extraction conditions. The sakkoty date dibs had the highest sugar content compared to the siwi date dibs in all treatments except for the date dibs prepared by (2:1). For the same cultivar, with an increase in the enzyme percentage, an increase in the contents of total phenols and total flavonoids occurred at the same extraction conditions. The sakkoty date dibs had the highest contents from total phenols and total flavonoids compared to the siwi date dibs for all treatments. The date dibs treated with cellulase enzyme also showed the highest scores of sensory evaluation in all treatments compared to the control date dibs except for the treatment (4:1).
Effect of Mg Doping on the Physical Properties of Fe2O3 Thin Films for Photocatalytic Devices

Undoped and Mg-doped (y = [Mg2+]/[Fe3+] = 1, 2, 3, and 4 at.%) Fe2O3 thin films were synthesized by a simple spray pyrolysis technique. The thin films were extensively characterized. X-ray diffraction (XRD) and energy-dispersive spectroscopy (EDS) analysis confirmed the successful insertion of Mg in the rhombohedral structure of Fe2O3. In addition, scanning electronic microscope (SEM) and confocal microscope (CM) images showed a homogenous texture of the film, which was free of defects. The rough surface of the film obtained by spray pyrolysis is an important feature for photocatalysis and gas sensor applications. The direct band gap of the doped Fe2O3 films obtained for [Mg2+]/[Fe3+] = 3 at. % was Edir = 2.20 eV, which recommends the Mg-doped iron oxide as an optical window or buffer layer in solar cell devices. The photodegradation performance of Mg-doped Fe2O3 was assessed by studying the removal of methylene blue (MB) under sunlight irradiation, with an effective removal efficiency of 90% within 180 min. The excellent photodegradation activity was attributed to the strong absorption of Mg-doped Fe2O3 in the UV and most of the visible light, and to the effective separation of photogenerated charge carriers.
POTENCIAIS APLICABILIDADES DE TECNOLOGIAS DIGITAIS: UM ESTUDO SOBRE WEARABLES NA INDÚSTRIA DE ÓLEO E GÁS

O avanço da transformação digital tem propiciado uma crescente aplicação e uso de tecnologias em diversos campos e setores da sociedade contemporânea. Nesse sentido, diversos estudos têm apontado para as possibilidades e oportunidades da adoção de wearebles em indústrias de alta complexidade operacional como soluções voltadas para a segurança e saúde dos trabalhadores de vários setores. Ao examinar potenciais aplicabilidades de wearables segundo a percepção de trabalhadores da indústria de óleo e gás (O&G), este estudo propõe e desenvolve um quadro analítico das aplicabilidades de wearables com potencial para promover a segurança na indústria de O&G. O estudo revelou uma baixa utilização de wearables, e ao adotar uma abordagem orientada a experiência e opiniões dos trabalhadores, apresenta um mapa com pistas e oportunidades para processos de adoção e/ou desenvolvimento de wearables e tecnologias digitais similares.
Revealing Intra- and Intermolecular Interactions Determining Physico-Chemical Features of Selected Quinolone Carboxylic Acid Derivatives

The intra- and intermolecular interactions of selected quinolone carboxylic acid derivatives were studied in monomers, dimers and crystals. The investigated compounds are well-recognized as medicines or as bases for further studies in drug design. We employed density functional theory (DFT) in its classical formulation to develop gas-phase and solvent reaction field (PCM) models describing geometric, energetic and electronic structure parameters for monomers and dimers. The electronic structure was investigated based on the atoms in molecules (AIM) and natural bond orbital (NBO) theories. Special attention was devoted to the intramolecular hydrogen bonds (HB) present in the investigated compounds. The characterization of energy components was performed using symmetry-adapted perturbation theory (SAPT). Finally, the time-evolution methods of Car–Parrinello molecular dynamics (CPMD) and path integral molecular dynamics (PIMD) were employed to describe the hydrogen bond dynamics as well as the spectroscopic signatures. The vibrational features of the O-H stretching were studied using Fourier transformation of the autocorrelation function of atomic velocity. The inclusion of quantum nuclear effects provided an accurate depiction of the bridged proton delocalization. The CPMD and PIMD simulations were carried out in the gas and crystalline phases. It was found that the polar environment enhances the strength of the intramolecular hydrogen bonds. The SAPT analysis revealed that the dispersive forces are decisive factors in the intermolecular interactions. In the electronic ground state, the proton-transfer phenomena are not favourable. The CPMD results showed generally that the bridged proton is localized at the donor side, with possible proton-sharing events in the solid-phase simulation of stronger hydrogen bridges. However, the PIMD enabled the quantitative estimation of the quantum effects inclusion—the proton position was moved towards the bridge midpoint, but no qualitative changes were detected. It was found that the interatomic distance between the donor and acceptor atoms was shortened and that the bridged proton was strongly delocalized.
A physics-based statistical random telegraph noise model

Low Frequency Noise (LFN) and Random Telegraph Noise (RTN) are performance limiters in many analog and digital circuits. For small area devices, the noise power spectral density can easily vary by many orders of magnitude, imposing serious threat on circuit performance and possibly reliability. In this thesis, we propose a new RTN model to describe the statistics of the low frequency noise in MOSFETs. Using the proposed model, we can explain and calculate the Expected value and Variability of the noise as function of devices’ biases, geometry and physical parameters. The model is validated through numerous experimental results for n-channel and p-channel devices from different CMOS technology nodes. We show that the LFN statistics of n-channel and p-channel MOSFETs can be described by the same mechanism. From our results and model, we show that the trap density of the p-channel device is a strongly varying function of the Fermi level, whereas for the n-channel the trap density can be considered constant. We also show and explain, using the proposed model, the impact of the halo-implanted regions on the statistics of the noise. Using this model, we clarify why the variability, denoted by σ[log(SId)], of RTN/LFN doesn't follow a 1/√area dependence; and we demonstrate that the noise, and its variability, found in our measurements can be modeled using reasonable physical quantities. Moreover, the proposed model can be used to calculate the percentile quantity of the noise, which can be used to predict or to achieve certain circuit yield.
3 on 3 Basketball Tournament

206-543-6452/TTY 206-685-7264 (FAX) dso@u.washington.edu FOR MORE INFORMATION CONTACT THE PROGRAMS OFFICE 543-8558 BETWEEN 8:30AM AND 5:00PM MONDAY FRIDAY IMLeagues.com ima@uw.edu washington.edu/ima To request disability accommodation contact the Disability Services Office at least ten days in advance at: The tournament will feature open divisions for men and women. Teams will be scheduled into preliminary pool play followed by a single elimination tournament. Teams are guaranteed three games. We will use IMLeagues.com to manage the tournament.