Miracle-dz/UniFAR-FTUs huggingface dataset:
A comparison of two population-based household surveys in Uganda for assessment of violence against youth

Violence is associated with health-risk behaviors, potentially contributing to gender-related HIV incidence disparities in sub-Saharan Africa. Previous research has demonstrated that violence, gender, and HIV are linked via complex mechanisms that may be direct, such as through forced sex, or indirect, such as an inability to negotiate safe sex. Accurately estimating violence prevalence and its association with HIV is critical in monitoring programmatic efforts to reduce both violence and HIV. We compared prevalence estimates of violence in youth aged 15–24 years from two Ugandan population-based cross-sectional household surveys (Uganda Violence Against Children Survey 2015 [VACS] and Uganda Population-based HIV Impact Assessment 2016–2017 [UPHIA]), stratified by gender. UPHIA violence estimates were consistently lower than VACS estimates, including lifetime physical violence, recent intimate partner physical violence, and lifetime sexual violence, likely reflecting underestimation of violence in UPHIA. Multiple factors likely contributed to these differences, including the survey objectives, interviewer training, and questionnaire structure. VACS may be better suited to estimate distal determinants of HIV acquisition for youth (including experience of violence) than UPHIA, which is crucial for monitoring progress toward HIV epidemic control.
Impact of protocolized postarrest care with targeted temperature management on the outcomes of cardiac arrest survivors without temperature management

Abstract Introduction Protocolized postarrest care that includes targeted temperature management (TTM) improves survival and neurological outcomes in cardiac arrest survivors. Whether the accumulated experience regarding the use of the protocolized approach also benefits patients who did not undergo TTM has yet to be investigated. Methods Adults (≥18 years old) with nontraumatic cardiac arrest and who survived to intensive care unit (ICU) admission were retrospectively recruited from a single tertiary medical centre from 2006 to 2009 and 2011 to 2017. Patients were excluded if they had traumatic injuries, were pregnant, did not survive to ICU admission, regained clear consciousness within 3 h after the return of spontaneous circulation, or underwent TTM. The sum of TTM cases since 2006 and before the cardiac arrest of each enrolled patient was used as a substitute index for the amount of experience accumulated from the use of protocolized TTM care. Results In total, 802 non-TTM patients were enrolled in the final analysis. The rate of survival to hospital discharge increased from 25.9% in 2006 to 33.3% in 2017. Regarding neurological recovery at hospital discharge, the incidence of favourable neurological function (cerebral performance category: 1 or 2) increased from 10.3% in 2006 to 23.5% in 2017. A multiple logistic regression indicated a significant association between the cumulative TTM case numbers and neurological outcomes in patients who did not receive TTM. Conclusions The improvement of neurological outcomes in adult nontraumatic cardiac arrest survivors who did not receive TTM was associated with the cumulative number of cases receiving protocolized TTM care. In the era of TTM, the use of only historical control data might lead to bias, which is caused by overlooking the influence of a more refined protocolized postarrest care that includes TTM. KEY MESSAGE The cumulative number of cases receiving protocolized TTM care, which we used as a substitute index for the amount of experience accumulated from the use of protocolized postarrest care that includes TTM, was associated with the improvement of neurological outcomes in adult nontraumatic cardiac arrest survivors who did not receive TTM.
Stone fruit maturity indices: a descriptive review

Information published on nectarine, plum and peach fruit maturity between 1980 and 1992 is reviewed. The advantages and disadvantages of different maturity indexes are discussed. The use of ground color, although an imperfect index, is considered the most practical and reliable method for determining minimum maturity. Fruit firmness is an excellent indicator of maximum maturity. A combination of ground color and fruit firmness may be better than a single index to assay stone fruit maturity. Fruit soluble solids content (SSC) varies significantly among orchards, as well as from tree to tree and, therefore, is not reliable indicator of fruit maturity. It is hoped that the development of new technologies in the near future such as near infrared (NIR), magnetic resonance (MR), light transmittance (LT) and sound detection will lead to an ideal, non-destructive, reliable maturity index for the nectarine, peach and plum fruit industry.
Maternal Western diet exposure increases periportal fibrosis beginning in utero in nonhuman primate offspring

Maternal obesity affects nearly one-third of pregnancies and is a major risk factor for nonalcoholic fatty liver disease (NAFLD) in adolescent offspring, yet the mechanisms behind NAFLD remain poorly understood. Here, we demonstrate that nonhuman primate fetuses exposed to maternal Western-style diet (WSD) displayed increased fibrillar collagen deposition in the liver periportal region, with increased ACTA2 and TIMP1 staining, indicating localized hepatic stellate cell (HSC) and myofibroblast activation. This collagen deposition pattern persisted in 1-year-old offspring, despite weaning to a control diet (CD). Maternal WSD exposure increased the frequency of DCs and reduced memory CD4+ T cells in fetal liver without affecting systemic or hepatic inflammatory cytokines. Switching obese dams from WSD to CD before conception or supplementation of the WSD with resveratrol decreased fetal hepatic collagen deposition and reduced markers of portal triad fibrosis, oxidative stress, and fetal hypoxemia. These results demonstrate that HSCs and myofibroblasts are sensitive to maternal WSD-associated oxidative stress in the fetal liver, which is accompanied by increased periportal collagen deposition, indicative of early fibrogenesis beginning in utero. Alleviating maternal WSD-driven oxidative stress in the fetal liver holds promise for halting steatosis and fibrosis and preventing developmental programming of NAFLD.
Alterations of tibialis anterior muscle activation pattern in subjects with type 2 diabetes and diabetic peripheral neuropathy

Diabetic peripheral neuropathy (DPN) is associated with loss of motor units (MUs), which can cause changes in the activation pattern of muscle fibres. This study investigated the pattern of muscle activation using high-density surface electromyography (HD-sEMG) signals from subjects with type 2 diabetes mellitus (T2DM) and DPN. Thirty-five adults participated in the study: 12 healthy subjects (HV), 12 patients with T2DM without DPN (No-DPN) and 11 patients with T2DM with DPN (DPN). HD-sEMG signals were recorded in the tibialis anterior muscle during an isometric contraction of ankle dorsiflexion at 50% of the maximum voluntary isometric contraction (MVIC) during 30-s. The calculated HD-sEMG signals parameters were the normalised root mean square (RMS), normalised median frequency (MDF), coefficient of variation (CoV) and modified entropy (ME). The RMS increased significantly (p = 0.001) with time only for the DPN group, while the MDF decreased significantly (p < 0.01) with time for the three groups. Moreover, the ME was significantly lower (p = 0.005), and CoV was significantly higher (p = 0.003) for the DPN group than the HV group. Using HD-sEMG, we have demonstrated a reduction in the number of MU recruited by individuals with DPN. This study provides proof of concept for the clinical utility of this technique for identifying neuromuscular impairment caused by DPN.
Reliability of pain scores during a body weight support protocol in individuals with knee osteoarthritis

Abstract Purpose To explore the reliability of percentage of Body Weight Support (BWS) needed for maximal pain relief and of pain scores across 12 walking conditions including pre and post-over-ground walking and an unweighting protocol from 0% to 40% BWS on a lower body positive pressure (LBPP) treadmill for individuals with knee osteoarthritis (OA). Materials and methods Twenty individuals (64 ± 9.44 years) with knee OA completed over-ground walking and an unweighting protocol on an LBPP treadmill. The amount of BWS started at 0% and increased by 5% increments until it reached 40%. Pain scores were recorded at the end of each increment. Results The reliability of pain scores was assessed using a Spearman’s rho. This study found moderate reliability of the percentage of BWS for maximal pain relief. Additionally, there was good reliability of pain scores with pre and post-over-ground walking and from 0% BWS to 30% BWS, but moderate reliability of pain scores was found at 35% and 40% BWS. Conclusion This study supports the use of pain scores as a reliable measure during an unweighted walking session on an LBPP treadmill. IMPLICATIONS FOR REHABILITATION Both the OARSI and ACR recommend exercise in the treatment of individuals with knee OA but acknowledge that pain during exercise and exercise preference/accessibility are important when considering the type of exercise for an individual. LBPP treadmills decrease pain in individuals with knee OA during walking. Pain scores during unweighted walking show moderate to good reliability for individuals with knee OA. This study provides an unweighting protocol to use clinically to determine the Body Weight Support needed to decrease pain.
Association between poor food production and intimate partner violence among smallholder farmers in northwestern Benin

ABSTRACT Rates of intimate partner violence (IPV) remain concerningly high in Benin, particularly in the predominantly rural region of Atacora in the northwest. In the context of increasing food insecurity, concerns have been raised regarding the role that lack of food in the household may be playing in increasing the rate of IPV in this context. This study aims to investigate the association between household food production and IPV in Atacora, Benin. Using a social ecological model and drawing from family stress theory, we analysed data from a cross-sectional survey of 300 women in the study region. Logistic regression and sequential modelling results show that after controlling for individual, household and community level factors, insufficient food production is positively associated with women’s likelihood of experiencing physical (adjusted OR=6.50 [2.48, 17.04], p < .01) and sexual violence (adjusted OR=4.49 [1.68, 11.99], p < .01). We conclude that production-oriented interventions in rural farming communities may reduce women’s risk of IPV by increasing households’ access to food and reducing family stress. Long term interventions would do well to focus on improving women’s access to land and building capacity in the management of marital conflict without violence.
Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium

Abstract Even though sunlight is viewed as the most important determinant of 25-hydroxyvitamin D (25(OH)D) status, several European studies have observed higher 25(OH)D concentrations among north-Europeans than south-Europeans. We studied the association between geographical latitude (derived from ecological data) and 25(OH)D status in six European countries using harmonised immunoassay data from 81 084 participants in the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project (male sex 48·9 %; median age 50·8 years; examination period 1984–2014). Quantile regression models, adjusted for age, sex, decade and calendar week of sampling and time from sampling to analysis, were used for between-country comparisons. Up until the median percentile, the ordering of countries by 25(OH)D status (from highest to lowest) was as follows: Sweden (at 65·6–63·8°N), Germany (at 48·4°N), Finland (at 65·0–60·2°N), Italy (at 45·6–41·5°N), Scotland (at 58·2–55·1°N) and Spain (at 41·5°N). From the 75th percentile and upwards, Finland had higher values than Germany. As an example, using the Swedish cohort as a comparator, the median 25(OH)D concentration was 3·03, 3·28, 5·41, 6·54 and 9·28 ng/ml lower in the German, Finnish, Italian, Scottish and Spanish cohort, respectively (P-value < 0·001 for all comparisons). The ordering of countries was highly consistent in subgroup analyses by sex, age, and decade and season of sampling. In conclusion, we confirmed the previous observation of a north-to-south gradient of 25(OH)D status in Europe, with higher percentile values among north-Europeans than south-Europeans.
Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia

Previous studies have implicated several brain cell types in schizophrenia (SCZ), but the genetic impact of astrocytes is unknown. Considering their high complexity in humans, astrocytes are likely key determinants of neurodevelopmental diseases, such as SCZ. Human induced pluripotent stem cell (hiPSC)‐derived astrocytes differentiated from five monozygotic twin pairs discordant for SCZ and five healthy subjects were studied for alterations related to high genetic risk and clinical manifestation of SCZ in astrocyte transcriptomics, neuron‐astrocyte co‐cultures, and in humanized mice. We found gene expression and signaling pathway alterations related to synaptic dysfunction, inflammation, and extracellular matrix components in SCZ astrocytes, and demyelination in SCZ astrocyte transplanted mice. While Ingenuity Pathway Analysis identified SCZ disease and synaptic transmission pathway changes in SCZ astrocytes, the most consistent findings were related to collagen and cell adhesion associated pathways. Neuronal responses to glutamate and GABA differed between astrocytes from control persons, affected twins, and their unaffected co‐twins and were normalized by clozapine treatment. SCZ astrocyte cell transplantation to the mouse forebrain caused gene expression changes in synaptic dysfunction and inflammation pathways of mouse brain cells and resulted in behavioral changes in cognitive and olfactory functions. Differentially expressed transcriptomes and signaling pathways related to synaptic functions, inflammation, and especially collagen and glycoprotein 6 pathways indicate abnormal extracellular matrix composition in the brain as one of the key characteristics in the etiology of SCZ.
E4 engages uPAR and enolase-1 and activates urokinase to exert antifibrotic effects

Fibroproliferative disorders such as systemic sclerosis (SSc) have no effective therapies and result in significant morbidity and mortality. We recently demonstrated that the C-terminal domain of endostatin, known as E4, prevented and reversed both dermal and pulmonary fibrosis. Our goal was to identify the mechanism by which E4 abrogates fibrosis and its cell surface binding partner(s). Our findings show that E4 activated the urokinase pathway and increased the urokinase plasminogen activator (uPA) to type 1 plasminogen activator inhibitor (PAI-1) ratio. In addition, E4 substantially increased MMP-1 and MMP-3 expression and activity. In vivo, E4 reversed bleomycin induction of PAI-1 and increased uPA activity. In patients with SSc, the uPA/PAI-1 ratio was decreased in both lung tissues and pulmonary fibroblasts compared with normal donors. Proteins bound to biotinylated-E4 were identified as enolase-1 (ENO) and uPA receptor (uPAR). The antifibrotic effects of E4 required uPAR. Further, ENO mediated the fibrotic effects of TGF-β1 and exerted TGF-β1–independent fibrotic effects. Our findings suggest that the antifibrotic effect of E4 is mediated, in part, by regulation of the urokinase pathway and induction of MMP-1 and MMP-3 levels and activity in a uPAR-dependent manner, thus promoting extracellular matrix degradation. Further, our findings identify a moonlighting function for the glycolytic enzyme ENO in fibrosis.
Biallelic truncating variants in the muscular A‐type lamin‐interacting protein (MLIP) gene cause myopathy with hyperCKemia

Muscular A‐type lamin‐interacting protein (MLIP) is most abundantly expressed in cardiac and skeletal muscle. In vitro and animal studies have shown its regulatory role in myoblast differentiation and in organization of myonuclear positioning in skeletal muscle, as well as in cardiomyocyte adaptation and cardiomyopathy. We report the association of biallelic truncating variation in the MLIP gene with human disease in five individuals from two unrelated pedigrees.
Variable-Temperature Native Mass Spectrometry for Studies of Protein Folding, Stabilities, Assembly, and Molecular Interactions.

The structures and conformational dynamics of proteins, protein complexes, and their noncovalent interactions with other molecules are controlled specifically by the Gibbs free energy (entropy and enthalpy) of the system. For some organisms, temperature is highly regulated, but the majority of biophysical studies are carried out at room, nonphysiological temperature. In this review, we describe variable-temperature electrospray ionization (vT-ESI) mass spectrometry (MS)-based studies with unparalleled sensitivity, dynamic range, and selectivity for studies of both cold- and heat-induced chemical processes. Such studies provide direct determinations of stabilities, reactivities, and thermodynamic measurements for native and non-native structures of proteins and protein complexes and for protein-ligand interactions. Highlighted in this review are vT-ESI-MS studies that reveal 40 different conformers of chymotrypsin inhibitor 2, a classic two-state (native → unfolded) unfolder, and thermochemistry for a model membrane protein system binding lipid and its regulatory protein. Expected final online publication date for the Annual Review of Biophysics, Volume 51 is May 2022. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Phase-Spatial Beamforming Renders a Visual Brain Computer Interface Capable of Exploiting EEG Electrode Phase Shifts in Motion-Onset Target Responses

Objective: in this work, we aim to develop a more efficient visual motion-onset based Brain-computer interface (BCI). Brain-computer interfaces provide communication facilities that do not rely on the brain's usual pathways. Visual BCIs are based on changes in EEG activity in response to attended flashing or flickering targets. A less taxing way to encode such targets is with briefly moving stimuli, the onset of which elicits a lateralized EEG potential over the parieto-occipital scalp area called the motion-onset visual evoked potential (mVEP). Methods: We recruited 21 healthy subjects for an experiment in which motion-onset stimulations translating leftwards (LT) or rightwards (RT) were encoding 9 displayed targets. We propose a novel algorithm that exploits the phase-shift between EEG electrodes to improve target decoding performance. We hereto extend the spatiotemporal beamformer (stBF) with a phase extracting procedure, leading to the phase-spatial beamformer (psBF). Results: we show that psBF performs significantly better than the stBF (p < 0.001 for 1 and 2 stimulus repetitions and p < 0.01 for 3 to 5 stimulus repetitions), as well as the previously validated linear support-vector machines (p < 0.001 for 5 stimulus repetitions and p < 0.01 for 1,2 and 6 stimulus repetitions) and stepwise linear discriminant analysis decoders (p < 0.001 for all repetitions) when simultaneously addressing timing and translation direction. Conclusion: We provide evidence of decodability of joint direction and target in mVEP responses. Significance: the described methods can aid in the development of a faster and more comfortable BCI based on mVEPs.
Eliciting Gestures for Novel Note-taking Interactions

Handwriting recognition is improving in leaps and bounds, and this opens up new opportunities for stylus-based interactions. In particular, note-taking applications can become a more intelligent user interface, incorporating new features like autocomplete and integrated search. In this work we ran a gesture elicitation study, asking 21 participants to imagine how they would interact with an imaginary, intelligent note-taking application. Participants were prompted to produce gestures for common actions such as select and delete, as well as less common actions (for gesture interaction) such as autocomplete accept/reject, ‘hide’, and search. We report agreement on the elicited gestures, finding that while existing interactions are prevalent (like double taps and long presses) a number of more novel interactions (like dragging selected items to hotspots or using annotations) were also well-represented. We discuss the mental models participants drew on when explaining their gestures and what kind of feedback users might need to move to more stylus-centric interactions.
Development and Implementation of SVPWM Three-Phase Inverter

Aim at the development and realization of SVPWM three-phase inverter control by DSP, the concrete of method and technology by DSP of SVPWM control is given, the complete hardware circuit and DSP control program is designed, the core of source program and setting method of DSP register are given. The results show that, voltage waveform output from SVPWM three-phase inverter is stability and reliability, output frequency with high control precision. The paper has good applied value for engineering development of inverter.
Implementation of Low Cost and Advanced Slotless Brushless DC Motor Drive Using PLL Algorithm

In this article, in order to enhance the performance of Hall-ICs, a position signal synthesize control algorithm is developed. Also, considering diagnosis of permanent magnet brushless DC (PM BLDC) motor control and safety operation or system protection in case of having trouble and fault in one of Hall-ICs during operation, the developed two Hall-IC control scheme is applied. With the position signal of phase lock loop (PLL) control algorithm and the remainder scheme, one can operate the slotless PM BLDC motor in high performance.
Bottom-up approaches for multi-person pose estimation and it's applications: A brief review

Human Pose Estimation (HPE) is one of the fundamental problems in computer vision. It has applications ranging from virtual reality, human behavior analysis, video surveillance, anomaly detection, self-driving to medical assistance. The main objective of HPE is to obtain the person's posture from the given input. Among different paradigms for HPE, one paradigm is called bottom-up multi-person pose estimation. In the bottom-up approach, initially, all the key points of the targets are detected, and later in the optimization stage, the detected key points are associated with the corresponding targets. This review paper discussed the recent advancements in bottom-up approaches for the HPE and listed the possible high-quality datasets used to train the models. Additionally, a discussion of the prominent bottom-up approaches and their quantitative results on the standard performance matrices are given. Finally, the limitations of the existing methods are highlighted, and guidelines of the future research directions are given.