Miracle-dz/UniFAR-FTUs huggingface dataset:
Envolvimento e Percepção dos Consumidores em Relação a Marcas Reposicionadas

This study was designed to identify the relationship between consumers’ involvement with a brand, their perception of its repositioning, and their consumption of the brand after repositioning. The object of study, the McDonald’s fast food chain, included healthy items on its menu as part of a bid to reposition its brand. Data were collected via online questionnaires, which were answered by 214 individuals. Data were analyzed using econometrics, resulting in the preparation of a simultaneous equation model with two regressions, whose dependent variables were perception and consumption. The results indicated that perception of brand repositioning depended positively on the consumers’ attitudes towards a balanced diet and how often they frequent McDonald’s, while there was a negative relationship with the consumers’ age, sex, education, and how important they felt the nutritional value of foods was. The results suggest that perception is influenced by personal stimuli and emotional involvement with the brand. However, adherence to the brand after repositioning was not found to be influenced by any kind of involvement, but by the consumers’ personal stimuli.
Aggregated inference

Aggregated inference on distributed data becomes more and more important due to the larger size of data collected in different industries. Modeling and inference are needed in the case where data cannot be obtained at a central location; aggregated statistical inference is a major tool to solve the aforementioned problems. In the literature, problems under the setting of regression model (more generally, M‐estimator) are extensively studied. There are at least two popular techniques for distributed estimation: (a) averaging estimators from local locations and (b) the one‐step approach, which combines the simple averaging estimator with a classical Newton's method (using the local Hessian matrices) to generate a “one‐step” estimator. It is proved that under certain assumptions, the above constructed estimators enjoy the same asymptotic properties as the centralized estimator, which is obtained as if all data were available at a central location. We review the aforementioned two major estimations. It can be seen that, in Big‐Data problems, dividing the data to multiple machines and then using the aggregation technique to solve the estimation problem in parallel can speed up the computation with little compromise of the quality of the estimators. We discuss potential extensions to other models, such as support vector machine, principle component analysis, and so on. Numerical examples are omitted due to the space limitation; they can be easily found in the literature.
Antimalarial, Antitrypanosomal, Antimicrobial Activities and Volatile Oil Profile of Xylopia aethiopica (Dunal) Rich (Annonaceae)

The resistance of Plasmodium falciparum (P. falciparum) to well-recognized antimalarial drugs is now common in nearly every area of its prevalence; consequently, there is a need to explore therapeutic plants that have bioactive compounds which can be utilized in the manufacture of antimalarial drugs. The in vitro potency of the volatile oil (VO) of Xylopia aethiopica (X. aethiopica) was evaluated against P. falciparum 3D7 strain, a human malaria parasite, a good activity against the parasite P. falciparum was recorded with an IC50 of 14 µg/mL. The in vitro cytotoxicity of the fruit oil of X. aethiopica was determined at a concentration of 50 µg/mL against HeLa cells and was found to show no cytotoxicity effect at this concentration; this could be an indication of the safety of the fruit oil as a targeted drug for mammalian organisms. , The antibacterial property of the VO from the fruit of X. aethiopica, was evaluated in vitro; the fruit oil exhibited good antimicrobial activity against the tested microorganisms, with Klebsiella pneumoniae having the highest inhibition zone of 19.0 ± 1.4 mm. The result recorded for MBC/MFC confirms that VO of this plant can be used in therapeutic preparations, particularly in the infections brought about by some of these microorganisms as practiced by traditional healers in folkloric medicines. This appears to justify the numerous folkloric therapeutic uses of the aerial parts of this plant. The hydro distilled volatile oil from X. aethiopica was characterized by Gas Chromatography-Mass Spectrometry (GC-MS), an abundance of monoterpenes hydrocarbon (58.0%), followed by oxygenated monoterpenes (30.13%), sesquiterpene hydrocarbon (8.96%), and fatty acid (0.74%) were well represented. The significant quantitative constituents of the fruit oil are 1, 8-cineole (16.73%), β-pinene (11.59%), sabinene (10.76%), 1R-α-pinene (8.30%), α-phellandrene (8.34%).
Predictive Filter Flow Network for Universal Demosaicking

Demosaicking is an image reconstruction process for restoring full-color images from color ﬁlter array (CFA) data. In recent years, many deep convolutional neural network (CNN)-based demosaicking methods have been reported, and state-of-the-art accuracy has been achieved. In this paper, we propose a novel demosaicking method using the predictive ﬁlter ﬂow (PFF) network for various CFA patterns. The PFF is a model that predicts a spatial variant linear ﬁlter that transforms an input image into a target image. To incorporate the PFF into demosaicking, the proposed network synthesizes the ﬁlter ﬂow corresponding to each channel by means of a network trained by integrating RGB channels. Our model, designed to apply demosaicking with the PFF to various CFA patterns, provides versatility and extensibility. Experimental results demonstrate that the proposed method provides better or competitive results compared with several state-of-the-art deep-CNN-based demosaicking algorithms.
Validation of AD8-Philippines (AD8-P): A Brief Informant-Based Questionnaire for Dementia Screening in the Philippines

Aim This study was aimed at validating the Filipino version of AD8 (AD8-P). Methods Community-dwelling Filipino older persons aged ≥60 years, together with their informants, participated in this study. Psychologists independently interviewed the informants with AD8-P and administered the Filipino-validated Mini-Mental State Examination (MMSE-P) and Montreal Cognitive Assessment (MoCA-P) to the older persons. Neurologists and geriatrician conducted physical and neurological examination and Clinical Dementia Rating™ (CDR™) to determine cognitive diagnosis and were blinded with the results of AD8-P. Dementia was diagnosed based on DSM-IV-TR criteria. AD8-P discriminatory ability to screen for dementia was evaluated according to DSM-IV-TR diagnostic criteria for dementia. Results A total of 366 community-dwelling Filipino older persons aged ≥60 years, 213 with normal cognition and 153 with dementia, and their informants were included in this study. Majority (90%) were at the mildest stage of dementia. Area under the receiver-operating-characteristic curve (AUROC) for AD8-P was 0.94 (95% CI 0.92 to 0.96), demonstrating excellent overall predictive power to screen for dementia. The optimal AD8-P cut-off score with best balance sensitivity (91.5%) and specificity (77.9%) was ≥3. Conclusion AD8-P demonstrated good psychometric properties to screen for dementia, even at the earliest stage of cognitive decline.
GEODESY, CARTOGRAPHY AND AERIAL PHOTOGRAPHY

V. HLOTOV, KH. MARUSAZH 1 Department of Photogrammetry and Geoinformatics, Lviv Polytechnic National University, 12, S. Bandery Str. , Lviv, 79013, Ukraine, tel. 38 (032) 258-26-16, e-mail: Volodymyr.M. Hlotov@ lpnu.ua 2 Department of Photogrammetry and Geoinformatics Lviv Polytechnic National University, 12, S. Bandery Str. , Lviv, 79013, Ukraine, tel. 38 (098) 766-84-31, e-mail: Khrystyna.I. Marusazh@lpnu.ua
Lebenserwartung

Lebenserwartung Nicht zuletzt durch neue Medikamente hat sich die durchschnittliche Lebenserwartung in Deutschland seit 1980 von 69,6 Jahren bei Männern und 76,3 Jahren bei Frauen im Jahr 2009/2011 bei Männern 77,9 und bei Frauen 82,9 Jahre erhöht. Nach einer Studie von Lichtenberg tragen innovative Arzneimittel etwa 40 % zu dieser Verlängerung bei. Doch nicht nur die Lebensdauer, auch die Lebensqualität kann durch moderne Arzneimittel verbessert werden. Für beides werden nachfolgend konkrete Beispiele genannt, wobei sich alle Patientenzahlen auf Deutschland beziehen.
Impact of Social Networking Sites on Students’ Learning English Language at Tertiary Level in Bangladesh

With the advancement in technology, Social Networking Sites (SNS) are being used by millions of students in Bangladesh for various purposes. People use SNS for communication, interaction' sharing posts, photos, videos; creating blogs, sending messages, and for real time conversations (Zaidieh, 2012). Students can learn their target language through SNSs as these platforms engage students more and inspire them. Moreover, the usage of SNSs minimises learners’ fear and nervousness and authority of the instructor (Gilbert, Fiske, & Lindzey, 1998; Beauvois, 1998, cited in Millis, 2011). Moreover, an opportunity of interaction for both teachers and students is ensured through authentic tasks and materials which promote constructivist learning through meaningful communication (Woo, Herrington, Agostinho, & Reeves, 2007). This study has explored the impact of SNS in learning English at tertiary level. So, it focuses on the effects of Social Networking Sites in language learning platform, developing reading, writing, listening and speaking skills and creating ease to teachers and learners in English has been examined in this study. To investigate this, I implemented quantitative research method with 120 students studying Honour’s in English Language and Literature at Public, National and Private Universities. Forty students were selected randomly from each of the university category. All the students were surveyed by using close-ended questionnaire and later descriptive statistical method was used to analyse the data. Despite having hesitation of communicating with each other, it is clearly evident that students use SNS mainly Facebook to improve their language skills.
Parametric strategic management: genesis & pracsis

The author’s concept of parametric strategic management approach is considered in accordance with generally accepted strategic management conceptions. Simultaneously the article makes an attempt to substantiate application of qualitative comparative analysis as a relevant method of empirical verification and to construct one-dimensional model of employee’s labor participation as the demonstration of practical application of the author’s concept
Aesthetic Reasons

Aesthetic reasons are reasons to do and think various things. For example, it makes sense to wonder if a tree stump on the lawn was left there for environmental rather than aesthetic reasons, or for no reason at all. Aesthetic considerations of this kind are often contrasted with non-aesthetic reasons—such as moral or epistemic reasons. For example, they seem connected to pleasure-in-experience in a distinctive way that differs from paradigmatic moral reasons. Relatedly, the authority of aesthetic reasons has often been thought to involve less of an “external demand” upon us than in the other cases. In this chapter, I suggest that such distinctiveness and modesty coheres well with an anti-realist treatment that views them as non-objective in nature. I then go on to consider an alternative, more robustly realist conception of aesthetic reasons.
Lean Healthcare na atividade de aplicação de medicamentos na clínica médica de um hospital de médio porte

Com o desenvolvimento do Toyota Production System (TPS), a produção de pequenas quantidades com variedade de produtos era apropriada para a realidade do Japão. Como tais ideais iam de encontro à Produção em Massa, o TPS focou no aumento da eficiência com a eliminação metódica e completa dos desperdícios. Dessa forma, inseriuse, nos meios de produção, a filosofia da produção enxuta, que posteriormente foi denominada Lean Manufacturing. Com o passar do tempo, a produção enxuta inseriu-se em outras realidades existentes no mercado, tal como o setor de serviços, atingindo a saúde com o Lean Healthcare. A saúde exuta se intensifica nos ambientes brasileiros, nos quais os hospitais buscam atingir eficiência e qualidade com verbas, muitas vezes, menores do que a necessária. Dessa forma, o objetivo deste artigo é propor uma aplicação da filosofia Lean Healthcare na atividade de aplicação de medicamentos. A metodologia utilizada se baseia em dois pilares: o primeiro, denominado levantamento, pretende mapear o processo em que a atividade foco está inserida e, assim, obter os desperdícios associados, identificando a causa raiz do que vai ser tratado. Em seguida, o pilar proposta Lean irá propor uma ferramenta para sanar o desperdício em questão, aplicando as ações necessárias dentro de um cronograma e, por fim, recolher os resultados e comparálos com a medição inicial. Como resultados, espera-se melhorar os processos do hospital na ótica do Lean, de forma que eles reflitam em diminuição de valor não agregado, bem como obter informações concretas sobre a implementação dessa técnica, concluindo que a aplicação feita possa ser replicada de forma sistêmica em outros desperdícios, gerando uma proposta sistemática.
Evidence-based support for autistic people across the lifespan: Maximizing potential, minimizing barriers, and optimizing the person-environment fit

Autism is both a medical condition that can give rise to disability and an example of human neurological variation (‘neurodiversity’) that contributes to identity, with cognitive assets and challenges. We refer to this as the dual nature of autism. Enhancing adaptation and wellbeing is the ultimate goal for intervention/support. Evidence-based support for autistic people across the lifespan is emerging. Support should be collaborative between autistic individuals, their families, and service providers, taking a shared decision-making approach. To maximize the individual’s potential, comprehensive early intervention and parent-mediated intervention, ideally taking a naturalistic approach, may help support the early development of adaptive, cognitive and language skills. Targeted intervention of social skills and aspects of cognition may help but challenges remain for behavioural flexibility and generalisation to different contexts. To minimize barriers for an individual’s development and adaptation, augmentative and alternative communication may potentially reduce communication difficulties. Alleviating co-occurring health challenges by timely medical, pharmacological or psychological interventions is essential. Finally, optimizing the person-environment fit by creating autism-friendly contexts through reasonable adjustments is critical. This involves supporting families, reducing stigma, enhancing peer understanding of autism, and promoting true inclusion in education, community and work environments, alongside strong advocacy.
Vertebral Body Changes in the Lower Spine of Basketball Players

During sports activities, several important musculoskeletal structures are required to perform complex spinal movement patterns that involve bending and twisting at high speeds. Therefore, the spine is subject to the action of many forces, due to both physiological motion (flexion, extension, rotation, lateral flexion) and accessory motion (shearing tension, compression) [1]. Depending on the direction, magnitude, and point of application of the forces, the spine may suffer deformation and injury. Abnormalities of the spine may also cause injury and pain among athletes because of the unique demands related to each specific sports activity. Lumbar spine injuries represent a significant concern to the athletes, coaches, and physicians.
Prognostic Value of Electrocardiographic Abnormalities and Troponin-I Elevation in Hospitalized COVID-19 Patients

Background: Corona Virus Disease (COVID -19) patients present mainly with respiratory manifestations and viral pneumonia. The cardiovascular presentation includes early signs of acute myocardial injury. Troponin elevation is a frequent laboratory finding in hospitalized patients with the disease, and may reflect direct vascular injury or nonspecific supply-demand imbalance. In this work, we assessed the correlation between different ranges of Troponin elevation, Electrocardiographic (ECG) abnormalities and mortality. Methods and materials: It was a prospective observational study, conducted in four tertiary care Private Hospitals of Chattogram City of Bangladesh. The study enrolled 181 consecutive patients admitted to hospital from June 01, 2020 to December 31, 2020 due to Covid-19 disease on the basis of presentation of signs and symptoms severity. Upon admission, routine investigations cTnI and ECG were carried out. Results: Mean age of the patients was 54.3±7.3 years with 63.5% male. Hypertension was the most common comorbidity followed by diabetes and obesity. 57.1% of the patients had abnormal ECG. Abnormal axis deviation [26 % (left axis deviation 23.9% vs right axis deviation 2.0%)], Poor R wave progression (22.9%), T inversion (14.5%), left ventricular hypertrophy (LVH) (11.4%) followed by ST segment depression (8.3%) were major findings observed in the study population. Presence of LVH (p=0.008), ST segment elevation (p≤0.001), ST segment depression (p≤0.001) and T inversion (p=0.003) showed statistically significant association with Severe COVID-19 disease. 48.2% had raised cTnI level. Thirteen (7.2%) patients expired in hospital. The mortality rate increased with incrementally higher troponin group: 12/18 than mildly elevated troponin 1/63 (p < 0.01). The presence of an abnormal ECG finding resulted in significant in the intermediate Troponin elevation group (0.05-1 ng/ml) but not in the low (<0.05 ng/ml) or high (> 1 ng/ml) Troponin elevation groups. There were statistically significant association between between cTnI level and death; and between ECG findings and death. Conclusion: Study conclude that Troponin-I level and ECG are a prognostic factor for mortality in hospitalized COVID-19 patients. Bangladesh Heart Journal 2021; 36(2): 105-112
Activity of Phytochemical Constituents of Black Pepper and Rosemary Against Zika Virus: An In silico Approach

Zika Virus is an emerging viral disease, and its outbreak rapidly affects human health worldwide. Many research findings are going on to find effective antiviral therapeutics for treating the Zika virus since there is no immunization or medications available in practice. In this study, the inhibitory potential of selected 72 phytochemicals derived from Piper nigrum and Salvia rosmarinus were tested against RNA-dependent RNA polymerase of ZIKV. The structure of NS5 RdRp was predicted using the SWISS-MODEL, and the structural stability was evaluated using GROMACS. Drug-likeness properties were predicted using SwissADME, MolSoft, and PreADMET servers. The results exhibited that 57 phytochemicals, i.e., 26 from Piper nigrum and 31 from Salvia rosmarinus showed effective drug-likeness. These phytochemicals were docked against predicted binding sites of RdRp ZIKV using AutoDock Vina, and pharmacokinetic properties were also analyzed. This investigation has revealed that out of 57 phytochemicals, Piperine (-7.6Kcal/mol) and Isoscutellarein (-7.4Kcal /mol) have shown significant inhibitory potential compared to those of these currently utilized antiviral drugs against ZIKV selected target. Thus our research findings strongly suggested that phytochemicals derived from Black pepper and rosemary could be beneficial against ZIKV.
Comprehensive understanding of Tn5 insertion preference improves transcription regulatory element identification

Abstract Tn5 transposase, which can efficiently tagment the genome, has been widely adopted as a molecular tool in next-generation sequencing, from short-read sequencing to more complex methods such as assay for transposase-accessible chromatin using sequencing (ATAC-seq). Here, we systematically map Tn5 insertion characteristics across several model organisms, finding critical parameters that affect its insertion. On naked genomic DNA, we found that Tn5 insertion is not uniformly distributed or random. To uncover drivers of these biases, we used a machine learning framework, which revealed that DNA shape cooperatively works with DNA motif to affect Tn5 insertion preference. These intrinsic insertion preferences can be modeled using nucleotide dependence information from DNA sequences, and we developed a computational pipeline to correct for these biases in ATAC-seq data. Using our pipeline, we show that bias correction improves the overall performance of ATAC-seq peak detection, recovering many potential false-negative peaks. Furthermore, we found that these peaks are bound by transcription factors, underscoring the biological relevance of capturing this additional information. These findings highlight the benefits of an improved understanding and precise correction of Tn5 insertion preference.
Computed Tomography-guided Lung Biopsy: A Review of Techniques for Reducing the Incidence of Complications

Computed tomography-guided lung biopsy is a well-established method for the histological diagnosis of pulmonary lesions. There is abundant literature regarding the diagnostic yield of and complications associated with computed tomography-guided lung biopsy. Many studies have investigated the risk factors influencing pneumothorax. Conversely, there are a limited number of reports detailing techniques for reducing the incidence of pneumothorax or other complications. This study reviews the indications, diagnostic accuracy, and complications of computed tomography-guided lung biopsy. In addition, techniques for reducing the incidence of these complications were reviewed.
Massive hematemesis and melena stool: A case report of unusual manifestation of Cow’s milk protein intolerance

ABSTRACT Cow’s milk protein intolerance (CMPI) is a common condition that causes gastrointestinal bleeding in the first year of life. It is the most common cause of chronic blood loss and anemia; however, severe massive hematemesis is an uncommon condition. Herein, we present a case of severe massive hematemesis with melena stool in a six-month-old boy with cow’s milk protein intolerance. In this case, we described management used in poor developing countries.
Fraud in the banking system of Ukraine: ways to combat taking into account foreign experience

The article aims to identify effective ways to combat bank fraud in Ukraine. Using the method of systematic analysis of theoretical experience, practical measures and international legislation in the field of combating banking fraud, the main factors influencing the bank fraud level are identified: financial instability of the banking institution, lack of information about the client's credit history, poor internal control, low level of corporate governance, lack of a standard procedure for customers verification, lack of a unified register of bank employees, imperfect legal regulators and a banking control system. The study allowed to identify the characteristics of an effective banking fraud combating system: a clear definition of the legal framework, regulation subjects and objects, strict and guaranteed liability for violations of laws, cooperation of structural units and regulatory authorities at the domestic and international level, state control of financial monitoring. As a result of the study, it was concluded that the successful experience of developed countries, comprehensive implementation of measures to combat bank fraud (at the legislative, bank management and technological level) will not only reduce the level of bank fraud, but also corruption, money laundering and terrorist financing rate.