Miracle-dz/UniFAR-FTUs huggingface dataset:
Olanzapine-Induced Parkinsonism and Akathisia: A Case Report

This article sheds light on the case of a 22-year-old patient with paranoid schizophrenia. A treatment regimen of olanzapine (an atypical antipsychotic) of 15 mg/day was initiated for the patient and it was associated with extrapyramidal symptoms (EPS) such as drug-induced parkinsonism (DIP) and akathisia. Based on the different treatment regimens available, the patient was switched to an alternate antipsychotic along with anticholinergics, antihistamines, and benzodiazepines, following which the patient recovered well and did not report any further side effects. The highlighted case stresses the need for proper monitoring of the drug dose and sequential periodic examination of the patient to nullify the risk of adverse effects and poor compliance.
Association of modifiable factors with the development of physical fitness of Austrian primary school children: A 4-year longitudinal study

ABSTRACT Physical fitness (PF) shows favourable associations with several health indicators in children. Children’s PF depends on a variety of non-modifiable (e.g., sex and age) and modifiable factors (e.g., weight status and sports participation). The aim of this study was to evaluate the impact of modifiable and non-modifiable factors on the development of PF during the 4 years of primary school. A longitudinal study was carried out with 265 children. PF was assessed using the German Motor Performance Test 6–18, whereas modifiable and non-modifiable factors with parent’s and children’s questionnaires. Total PF z‐score increased by 1.4 standard deviations from 1st to 4th year and raw values of subtests improved by an average of about 40%. The variables “parents’ physical activity”, “never being overweight”, “sports club participation”, and “playing outside” were positively associated with PF development. The present study highlights that a variety of modifiable factors, both from children and their parents, are significantly associated with the development of children’s PF during primary education. Interventions should not only focus on direct actions, such as proposing specific exercise programs, but also aim at increasing parents’ awareness of their role model function in endorsing their children’s healthy active lifestyle, especially at early ages.
Fine-Scale Genetic Structure in the United Arab Emirates Reflects Endogamous and Consanguineous Culture, Population History, and Geography

Abstract The indigenous population of the United Arab Emirates (UAE) has a unique demographic and cultural history. Its tradition of endogamy and consanguinity is expected to produce genetic homogeneity and partitioning of gene pools while population movements and intercontinental trade are likely to have contributed to genetic diversity. Emiratis and neighboring populations of the Middle East have been underrepresented in the population genetics literature with few studies covering the broader genetic history of the Arabian Peninsula. Here, we genotyped 1,198 individuals from the seven Emirates using 1.7 million markers and by employing haplotype-based algorithms and admixture analyses, we reveal the fine-scale genetic structure of the Emirati population. Shared ancestry and gene flow with neighboring populations display their unique geographic position while increased intra- versus inter-Emirati kinship and sharing of uniparental haplogroups, reflect the endogamous and consanguineous cultural traditions of the Emirates and their tribes.
Telemedicine based on patient-reported outcomes in management of patients with inflammatory bowel disease in a real-life setting – a before and after cohort study

Abstract Background Avoidable appointments and increasing incidence of inflammatory bowel disease (IBD) call for alternative ways of organizing outpatient visits. In controlled studies, telemedicine including patient reported outcome (PRO) has shown to improve outcomes in IBD and reduce health care utilization. However, we lack studies of telemedicine implemented in everyday practice. We therefore described use of a PRO-based telemedicine follow-up (AmbuIBD) in a real-life setting and investigated the effect on outpatient visits and hospital admissions. Methods We conducted a cohort study including patients with IBD in an outpatient clinic at a Danish regional hospital August 2018. Data included extracts from the Patient Administration System and the AmbuFlex system between 2017 and August 2018, plus questionnaire data from clinicians. Descriptive statistics were used to describe use of AmbuIBD and differences between before and after results were tested with Wilcoxon’s signed-rank test. Results Of 848 patients in outpatient care, 77% were included in AmbuIBD. Most patients were set to answer a PRO questionnaire once a year (n = 407, 62%), and 66% of 1913 answered questionnaires were handled with no further contact. AmbuIBD was well accepted by clinicians. Outpatient visits the year after AmbuIBD compared to the year before were reduced with 14% (p ≤ .001). The largest reduction was for patients with mild or no disease activity (45%, p ≤ .001). No difference was found for hospital admissions. Conclusions AmbuIBD is feasible and well accepted when implemented in an outpatient clinic. More than half of patients are only followed by questionnaire, and we found a reduction in outpatient visits.
Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression

Platelets have a wide range of functions including critical roles in hemostasis, thrombosis, and immunity. We hypothesized that during acute inflammation, such as in life-threatening sepsis, there are fundamental changes in the sites of platelet production and phenotypes of resultant platelets. Here, we showed during sepsis that the spleen was a major site of megakaryopoiesis and platelet production. Sepsis provoked an adrenergic-dependent mobilization of megakaryocyte-erythrocyte progenitors (MEPs) from the bone marrow to the spleen, where IL-3 induced their differentiation into megakaryocytes (MKs). In the spleen, immune-skewed MKs produced a CD40 ligandhi platelet population with potent immunomodulatory functions. Transfusions of post-sepsis platelets enriched from splenic production enhanced immune responses and reduced overall mortality in sepsis-challenged animals. These findings identify a spleen-derived protective platelet population that may be broadly immunomodulatory in acute inflammatory states such as sepsis.
Piquing our interest: Insights into the role of PEAK3 in signaling and disease

Pseudokinases are critical signaling hubs that are increasingly appreciated as important disease targets. In this issue of Science Signaling, Hou et al. bring new insights into the signaling mechanisms of the pseudokinase PEAK3 by characterizing its epidermal growth factor–dependent interactome and demonstrating oncogenic effects of PEAK3 overexpression. Description The interactome of pseudokinase PEAK3 shows its role in cancer (Hou et al., in 22 February 2022 issue).
Interproximal contact loss at implant sites: a retrospective clinical study with a 10‐year follow‐up

Abstract Aim To assess the frequency and quantity of interproximal contact loss (ICL) between implant restorations and adjacent teeth after at least 10 years of follow‐up (FU). Methods Thirty‐nine patients (median age 57.3 years) with 80 implants were re‐examined at least 10 years after insertion of final restorations (single crowns or fixed dental prostheses (FDPs)). Baseline (insertion of the restorations) and FU examinations encompassed the following: Stone casts were scanned and superimposed for metric assessment of tooth movements, radiographs, and clinical measurements. Outcome measures at implant sites were as follows: the extent of tooth movement and the frequency of interproximal contact loss [ICL], peri‐implant marginal bone levels [MBLs], and clinical measurements (plaque control record [PCR], Bleeding on Probing [BOP], and probing depth [PD]). Data were analyzed statistically with generalized regression modeling with robust standard errors to account for within‐patient clustering at 5%. Results Interproximal contact loss for at least one contact point after 10 years was observed in 50% of all implants (with open interproximal spaces up to 1.64 mm). Mesial contact points were significantly more prone to ICL than distal ones (relative risk [RR] = 1.79; 95% confidence interval [CI] = 1.07–2.99; p = .03). The type of restoration had a significant effect on ICL, with FDPs of 2 implants being significantly more prone to mesial ICL than single crowns (RR = 1.52; 95% CI = 1.02–2.25; p = .04). ICL was also associated with a significant increase in PD (+0.46 mm (95% CI = 0.04–0.88 mm; p = .03)) compared to implant sites without ICL. BOP, MBLs, and PCR were not significantly influenced by ICL. Conclusion Interproximal contact loss was a common finding in 50% of the implant sites and was significantly associated with an increase in PD.
Phylogeography and transmission of M. tuberculosis in Moldova: A prospective genomic analysis

Background The incidence of multidrug-resistant tuberculosis (MDR-TB) remains critically high in countries of the former Soviet Union, where >20% of new cases and >50% of previously treated cases have resistance to rifampin and isoniazid. Transmission of resistant strains, as opposed to resistance selected through inadequate treatment of drug-susceptible tuberculosis (TB), is the main driver of incident MDR-TB in these countries. Methods and findings We conducted a prospective, genomic analysis of all culture-positive TB cases diagnosed in 2018 and 2019 in the Republic of Moldova. We used phylogenetic methods to identify putative transmission clusters; spatial and demographic data were analyzed to further describe local transmission of Mycobacterium tuberculosis. Of 2,236 participants, 779 (36%) had MDR-TB, of whom 386 (50%) had never been treated previously for TB. Moreover, 92% of multidrug-resistant M. tuberculosis strains belonged to putative transmission clusters. Phylogenetic reconstruction identified 3 large clades that were comprised nearly uniformly of MDR-TB: 2 of these clades were of Beijing lineage, and 1 of Ural lineage, and each had additional distinct clade-specific second-line drug resistance mutations and geographic distributions. Spatial and temporal proximity between pairs of cases within a cluster was associated with greater genomic similarity. Our study lasted for only 2 years, a relatively short duration compared with the natural history of TB, and, thus, the ability to infer the full extent of transmission is limited. Conclusions The MDR-TB epidemic in Moldova is associated with the local transmission of multiple M. tuberculosis strains, including distinct clades of highly drug-resistant M. tuberculosis with varying geographic distributions and drug resistance profiles. This study demonstrates the role of comprehensive genomic surveillance for understanding the transmission of M. tuberculosis and highlights the urgency of interventions to interrupt transmission of highly drug-resistant M. tuberculosis.
Nutrition for female athletes: What we know, what we don’t know, and why

ABSTRACT Men are often considered as the default sex for studies in sports nutrition. Indeed, most of the seminal work to date in sports nutrition has been exclusively conducted on male participants. The 2021 Olympic Games had 49% female participation, signalling [almost] parity between sportsmen and sportswomen at the most elite sporting level for the first time. The volume of sports nutrition research using women as participants has, however, not kept pace with this rise in participation and professionalism. Therefore, to highlight what we currently know and don't know about sports nutrition for female athletes we invited well-known and emerging researchers to contribute to this special edition on Nutrition for Female Athletes. Contributions cover three main themes: dietary and hydration requirements; low energy availability and making weight; and dietary supplements and gut health. In addition, this special addition explores why our understanding on this topic is limited and how we can further progress and promote this research area.
The power of the (imperfect) palindrome: Sequence‐specific roles of palindromic motifs in gene regulation

In human languages, a palindrome reads the same forward as backward (e.g., ‘madam’). In regulatory DNA, a palindrome is an inverted sequence repeat that allows a transcription factor to bind as a homodimer or as a heterodimer with another type of transcription factor. Regulatory palindromes are typically imperfect, that is, the repeated sequences differ in at least one base pair, but the functional significance of this asymmetry remains poorly understood. Here, we review the use of imperfect palindromes in Drosophila photoreceptor differentiation and mammalian steroid receptor signaling. Moreover, we discuss mechanistic explanations for the predominance of imperfect palindromes over perfect palindromes in these two gene regulatory contexts. Lastly, we propose to elucidate whether specific imperfectly palindromic variants have specific regulatory functions in steroid receptor signaling and whether such variants can help predict transcriptional outcomes as well as the response of individual patients to drug treatments.
Predictors of mortality among adolescents and young adults living with HIV on antiretroviral therapy in Dar es Salaam, Tanzania: a retrospective cohort study

Global AIDS‐related deaths have declined by only 10% among adolescents since its peak in 2003. This is disproportionately low compared to a decline of 74% among children aged 0–9 years old. We determined the magnitude of, and predictors of mortality among adolescents and young adults living with HIV on antiretroviral therapy (ART) in Dar‐es‐Salaam, Tanzania.
Mupirocin-Loaded Chitosan Microspheres Embedded in Piper betle Extract Containing Collagen Scaffold Accelerate Wound Healing Activity

This study reports the formulation of mupirocin-loaded chitosan microspheres embedded in Piper betle extract containing collagen scaffold as combinational drug delivery for improved wound healing. Selection of chitosan type (molecular weight and degree of deacetylation) was carried out based on their antibacterial efficacy. The low molecular weight chitosan was selected owing to the highest antibacterial action against gram-positive as well as gram-negative bacteria. Low molecular weight chitosan-microspheres showed spherical shape with largely smooth surface morphology, 11.81% of mupirocin loading, and its controlled release profile. The XRD, DSC thermograms, and FT-IR spectral analysis revealed the mupirocin loaded in molecularly dispersed or in amorphous form, and having no chemical interactions with the chitosan matrix, respectively. The in vivo study indicates potential effect of the mupirocin, Piper betle, and chitosan in the collagen scaffold in the wound healing efficiency with approximately 90% wound healing observed at the end of 15 days of study for combinational drug-loaded chitosan microspheres-collagen scaffold-treated group. The histopathology examination further revealed tissue lined by stratified squamous epithelium, collagen deposition, fibroblastic proliferation, and absence of inflammation indicating relatively efficient wound healing once treated with combinational drug-loaded chitosan microspheres containing scaffold.
Developmental experiences alter the temporal processing characteristics of the visual cortex: Evidence from deaf and hearing native signers

To date, the extent to which early experience shapes the functional characteristics of neural circuits is still a matter of debate. In the present study, we tested whether congenital deafness and/or the acquisition of a sign language alter the temporal processing characteristics of the visual system. Moreover, we investigated whether, assuming cross‐modal plasticity in deaf individuals, the temporal processing characteristics of possibly reorganised auditory areas resemble those of the visual cortex. Steady‐state visual evoked potentials (SSVEPs) were recorded in congenitally deaf native signers, hearing native signers, and hearing nonsigners. The luminance of the visual stimuli was periodically modulated at 12, 21, and 40 Hz. For hearing nonsigners, the optimal driving rate was 12 Hz. By contrast, for the group of hearing signers, the optimal driving rate was 12 and 21 Hz, whereas for the group of deaf signers, the optimal driving rate was 21 Hz. We did not observe evidence for cross‐modal recruitment of auditory cortex in the group of deaf signers. These results suggest a higher preferred neural processing rate as a consequence of the acquisition of a sign language.
Differentiation Between Solid Pseudopapillary Neoplasm of the Pancreas and Nonfunctional Pancreatic Neuroendocrine Neoplasm Using Endoscopic Ultrasound

Objectives We investigated the utility of endoscopic ultrasound (EUS) for differentiating between solid pseudopapillary neoplasm of the pancreas (SPN) and pancreatic neuroendocrine neoplasm (PanNEN). Methods A retrospective analysis was performed on 29 and 77 consecutive patients with pathologically proven SPN and nonfunctional PanNEN. In patients who underwent contrast-enhanced harmonic EUS (CH-EUS), lesions were classified into 3 vascular patterns (hypoechoic/isoechoic/hyperechoic), and the presence of “the alveolus nest sign,” which we previously reported as a characteristic feature of SPN on CH-EUS, was also assessed. Results Conventional EUS findings showed that calcification echoes were significantly more frequent in SPN lesions than in PanNEN lesions (19/29 [66%] vs 21/77 [27%], P = 0.001) as was internal isoechogenicity or hyperechogenicity (10/29 [34%] vs 11/77 [14%], P = 0.029). Contrast-enhanced harmonic EUS findings showed that SPN lesions more frequently had the isoechoic or hypoechoic vascular pattern, and significantly more frequently had the alveolus nest sign (18/25 [72%] vs 4/60 [7%], P < 0.001). In a multivariate analysis, the presence of the alveolus nest sign contributed the most to the SPN diagnosis (odds ratio, 70; 95% confidence interval, 6.2–786). Conclusions Endoscopic ultrasound, particularly the presence of the alveolus nest sign on CH-EUS, is useful for differentiating SPN from PanNEN.
PER prediction for bit-loaded BICM-OFDM with hard-decision Viterbi decoding

Abstract – This article analyzes the performance of orthogonal frequency division multiplexing (OFDM) systems with bit-interleaved and coded modulation (BICM) over frequency-selective broadband wireless channels. The instantaneous packet error ratio (PER) determines the quality of a given modulation and coding scheme (MCS). An accurate PER prediction method for hard-decision Viterbi decoders is proposed, and is further extended for bit-loading. A realistic system-level improvement estimate is achieved by relating bitloading, code properties and instantaneous PER.
Larger Volume and Higher Fat Content of the Pancreatic Head Are Predictive Factors for Postendoscopic Retrograde Cholangiopancreatography Pancreatitis

Objectives Acute pancreatitis is the most critical complication of endoscopic retrograde cholangiopancreatography (ERCP). In this study, we investigated the association between the volume/fat content of the pancreatic head and the incidence of post-ERCP pancreatitis (PEP). Methods We retrospectively enrolled 157 patients who underwent ERCP. The volume and fat content of the pancreas were calculated by multislice computed tomographic imaging by using a volume analyzer. Multivariate analysis was performed to identify risk factors for PEP. Results The mean volumes of the whole pancreas and pancreatic head were significantly larger, and the fat content of the pancreatic head was significantly higher in the PEP group (P < 0.01). There were no significant differences in the mean volume and fat content of the pancreatic body and tail in the PEP group. Multivariate analysis revealed that the pancreatic guidewire placement (odds ratio [OR], 12.4; P < 0.01), pancreatic head volume (OR, 5.3; P < 0.01), and the pancreatic head fat content (OR, 4.8; P < 0.01) were independent risk factors for PEP. Conclusions The pancreatic head volume and fat content were independent predicting factors of PEP. Quantitative assessment of the pancreas may contribute to the prediction of PEP onset.
The Hub and Spoke Network and Its Application in Transportation Geography

After the 1978 Airline Deregulation Act,USA,more and more airline companies in USA adopted the hub-and-spoke systems.Flights from different origins to the same destination or from the same origin to different destinations were consolidated via intermediate nodes instead of direct interlink.Compared to traditional many-to-many network,these configurations reduce and simplify network construction costs,centralize commodity handling and sorting,and allow carriers to take advantage of scale economies through consolidation of flows.O'Kelly presented the first recognized mathematical formulation for a p-hub location problem by studying airline passenger networks in 1987,and the wide application of hub and spoke network motivated the geographers' study on it.The hub location problem is concerned with locating hub facilities and allocating demand nodes to hubs in order to route the traffic between origin-destination pairs.In fact,hub location problem is a complex mixture of location analysis and spatial interaction theory.The hub location problem can be classified to four fundamental types of discrete facility location problems:the p-median problem,the hub location problem with fixed costs,the p-center problem and the hub covering problems.The hub and spoke network was mainly used by airline company,so the research also focused on the application to airlines.Moreover,it can also be applied in maritime transport system,telecommunication systems,post service or rail systems and so on.Few researches on hub and spoke can be found in Chinese literature,so the model constructing and application are the main subjects for further research.
Are there positive effects of having a sibling with special needs? Empathy and prosociality of twins of children with non-typical development.

This study examined whether typically developing (TD) twins of non-TD children demonstrate enhanced empathy and prosociality. Of 778 Hebrew-speaking Israeli families who participated in a twin study, 63 were identified to have a non-TD child with a TD twin, and 404 as having both twins TD. TD twins of non-TD children (27% males) were compared to the rest of the cohort of TD children (46% males) on measures of empathy and prosociality. Participants were 11 years old. TD twins of non-TD children scored significantly higher than TD twins of TD children in a measure of cognitive empathy (d = .43). No differences were found in emotional empathy and prosociality. The specificity of the positive effect on cognitive empathy is discussed.
Info-communication services in the Smart City

This article is a continuation of a series of publications on Smart Cities. The article deals with issues related to the development and maintenance of info-communication services in smart cities. In this paper, we focus on two points. Firstly, it is the urban platform, which in some works called urban operating systems. Here are tools for creating services and proper support for their work. And the second point is the list of direct examples of services for Smart Cities. All such examples, in fact, are mashups. In other words, they are applications that use data from multiple sources.