Miracle-dz/UniFAR-FTUs huggingface dataset:
Nonisothermal two‐ and three‐dimensional flow simulations of inelastic and viscoelastic fluids by a finite‐volume method

This paper applies the finite‐volume method to computations of steady flows of viscous and viscoelastic incompressible fluids in complex two and three‐dimensional geometries. The materials adopted in the study obey different constitutive laws: Newtonian, purely viscous Carreau–Yasuda as also Upper‐Convected Maxwell and Phan‐Thien/Tanner differential models, with a Williams–Landel–Ferry (WLF) equation for temperature dependence. Specific analyses are made depending on the rheological model. A staggered grid is used for discretizing the equations and unknowns. Stockage possibilities allow us to solve problems involving a great number of degrees of freedom, up to 1 500 000 unknowns with a desk computer. In relation to the fluid properties, our numerical simulations provide flow characteristics for various 2D and 3D configurations and demonstrate the possibilities of the code to solve problems involving complex nonlinear constitutive equations with thermal effects. Copyright © 2009 John Wiley & Sons, Ltd.
Size control of catalytic nanoparticles by thermal treatment and its application to diameter control of single-walled carbon nanotubes

The authors report size control of catalytic nanoparticles by thermal annealing for diameter-controlled growth of single-walled carbon nanotubes (SWNTs). They found that Co nanoparticle-size gradually decreased through repetitive annealing at 1000°C in Ar ambient. Results of x-ray photoelectron spectroscopy and secondary ion mass spectroscopy show that thermal evaporation is responsible for the decrease. After SWNT growth using this phenomenon, the authors found that thinner SWNTs with a narrower diameter distribution grew as the nanoparticles became smaller. Their results provide a rational and straightforward technique to prepare catalysts having a desirable size and uniformity toward diameter-controlled SWNT growth.
Ultrathin organic bulk heterojunction solar cells: Plasmon enhanced performance using Au nanoparticles

The plasmonic effect of gold nanoparticles (AuNPs) enhances light absorption and, thus, the efficiency of organic bulk heterojunction solar cells with poly (3-hexylthiophene) (P3HT): [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) as active layer. We report optimization of this enhancement by varying the attachment density of the self-assembled AuNPs on silanized ITO using N1-(3-trimethoxysilylpropyl)diethylenetriamine. Using finite difference time domain simulations, the thicknesses of poly (3,4-ethylenedioxythiophene) (PEDOT): poly (styrenesulfonate) (PSS) and P3HT:PCBM layers were suitably varied to ensure broadband optical absorption enhancement and minimal exciton quenching within the active layer. Our experimental results demonstrate that for solar cell structures with 20% surface coverage, absorption is increased by 65% as predicted by simulations. Further, we show that AuNPs increase the efficiency by 30% and that silanization of ITO positively impacts device performance.
A Representation of $Spin(4)$ on the Eigenspinors of the Dirac Operator on $S^3$

We construct the eigenspinors of the Dirac Operator $D_{3}$ on $S^{3}$ from a representation theoretical point of view and give a representation of Spin (4) on them explicitly. These eigenspinors are extended to zero mode spinors of the Dirac operator $D_{4}^{\pm}$ on upper or lower hemisphere of $S^{4}$ .
Initial growth stage and optical properties of a three‐dimensional InAs structure on GaAs

A few mololayers of InAs is heteroepitaxially grown on GaAs substrate by molecular‐beam epitaxy. Structure and optical properties are investigated. Reflection high‐energy electron‐diffraction observation reveals that an InAs layer forms a three‐dimensional structure with specific facets after two‐dimensional growth. The transmission electron microscope observation shows that these structures have structural anisotropy in the growth plane. Photoluminescense spectroscopy shows that the luminescence from the InAs structures exhibits the polarization property caused by the quantum dot effect of the structural anisotropy.
Probabilistic Verification of Monthly Temperature Forecasts

Abstract Monthly forecasting bridges the gap between medium-range weather forecasting and seasonal predictions. While such forecasts in the prediction range of 1–4 weeks are vital to many applications in the context of weather and climate risk management, surprisingly little has been published on the actual monthly prediction skill of existing global circulation models. Since 2004, the European Centre for Medium-Range Weather Forecasts has operationally run a dynamical monthly forecasting system (MOFC). It is the aim of this study to provide a systematic and fully probabilistic evaluation of MOFC prediction skill for weekly averaged forecasts of surface temperature in dependence of lead time, region, and season. This requires the careful setup of an appropriate verification context, given that the verification period is short and ensemble sizes small. This study considers the annual cycle of operational temperature forecasts issued in 2006, as well as the corresponding 12 yr of reforecasts (hindcasts). Th.
Differential Susceptibility of Fetal Retinal Pigment Epithelial Cells, hiPSC- Retinal Stem Cells, and Retinal Organoids to Zika Virus Infection

Zika virus (ZIKV) causes microcephaly and congenital eye disease. The cellular and molecular basis of congenital ZIKV infection are not well understood. Here, we utilized a biologically relevant cell-based system of human fetal retinal pigment epithelial cells (FRPEs), hiPSC-derived retinal stem cells (iRSCs), and retinal organoids to investigate ZIKV-mediated ocular cell injury processes. Our data show that FRPEs were highly susceptible to ZIKV infection exhibiting increased apoptosis, whereas iRSCs showed reduced susceptibility. Detailed transcriptomics and proteomics analyses of infected FRPEs were performed. Nucleoside analogue drug treatment inhibited ZIKV replication. Retinal organoids were susceptible to ZIKV infection. The Asian genotype ZIKV exhibited higher infectivity, induced profound inflammatory response, and dysregulated transcription factors involved in retinal organoid differentiation. Collectively, our study shows that ZIKV affects ocular cells at different developmental stages resulting in cellular injury and death, further providing molecular insight into the pathogenesis of congenital eye disease.
Source Footprint Considerations in the Determination of Volatile Organic Compound Fluxes from Forest Canopies

Abstract Above-canopy sampling of trace gases to determine volatile organic compound (VOC) emissions should be interpreted in terms of footprint considerations. This can be accomplished by defining the upwind canopy areas effectively sampled under the given wind and stability conditions. Using solutions of the advection–diffusion equation adjusted through controlled tracer gas (SF6) release experiments in the Boreal Ecosystem Atmosphere Study of 1994, sampling of VOC concentrations and fluxes over a forest whose VOC sources are heterogeneous (Camp Borden) are studied. Analysis demonstrates that the variability observed in measured VOC fluxes could be accounted for by varying numbers of randomly distributed clumps of emitter species within a varying footprint. It suggests that heterogeneity of the forest canopy, in terms of source distribution of VOCs, has to be explicitly considered in estimates of source strength from above-canopy concentration/flux sampling.
Lake stability and anoxia dynamics revealed from high frequency vertical profiling in a eutrophic polymictic reservoir

ABSTRACT High-frequency water quality monitoring is rapidly growing in freshwater research and management. Sensor deployments at fixed depths in naturally formed lakes dominate the current understanding of ecosystem dynamics, with comparatively few studies focusing on reservoirs. Here we examined how environmental parameters affect the water column stability and dissolved oxygen (DO) dynamics in a North Texas eutrophic reservoir. We used an autonomous water quality monitoring profiler that recorded temperature, DO, and pH as well as wind speed, wind direction, and air temperature from an on-platform mounted weather station. Data were collected every 2 h from 25 April to 29 October 2019, with each profile spanning from the surface to 10 m depth at 0.5 m steps. Throughout most of the sampling period, the lake had no distinct thermocline, but we observed an oxycline throughout most of the monitoring period, with multiple mixing events. Near the sediments, periods of anoxia lasting hours to days were first observed in May, and July through September were chronically anoxic. In August and September, DO was frequently <2.0 mg L−1 throughout the entire water column, with 2 periods of total water column anoxia. Surface DO measurements for each 2 h interval were highly synchronous with Schmidt stability. During decreasing and low Schmidt stability or Lake Number, the oxycline destabilized in association with changes in wind direction and speed. Our results indicate that DO can be highly dynamic in polymictic reservoirs, with strong implications for carbon and nitrogen biogeochemical cycles.
Genotype-Dependent Jasmonic Acid Effect on Pinus sylvestris L. Growth and Induced Systemic Resistance Indicators

Due to temperature changes, forests are expected to encounter more stress than before, both in terms of biotic factors, such as increased insect attacks, and abiotic factors, such as more frequent droughts. Priming trees to respond to these changes faster and more effectively would be beneficial. Induced systemic resistance (ISR) is a mechanism that is turned on when plants encounter unfavorable conditions. Certain elicitors, such as jasmonic acid (JA) are known to induce plants’ metabolic response. However, even though studies on ISR in herbaceous species are common and varied ISR elicitors can be used in agriculture, the same cannot be said about trees and forestry enterprises. We aimed to investigate whether JA used in different concentrations could induce metabolic changes (total phenol content, total flavonoid content, photosynthesis pigment content, antioxidant enzyme activity) in Pinus sylvestris seedlings and how this varies between different pine half-sib families (genotypes). After six weeks with a single application of JA, pine seedlings in several pine genetic families exhibited increased antioxidant enzyme activity, total phenol content and carotenoid content that correlated positively with JA concentrations used. Results from other genetic families were varied, but in many cases, there was a significant response to JA, with a noticeable increase as compared to the unaffected group. The impact on chlorophyll content and flavonoids was less noticeable overall. A positive effect on seedling growth parameters was not observed in any of the test cases. We conclude that JA can induce systemic resistance after a single application exogenously in P. sylvestris seedlings and recommend that the use of JA needs to be optimized by selecting appropriate concentrations.
Restoring Voluntary Bimanual Activities of Patients With Chronic Hemiparesis Through a Foot-Controlled Hand/Forearm Exoskeleton

A significant number of stroke patients are permanently left with a hemiparetic upper limb after the poststroke six-month golden recovery period, resulting in a drastic decline in their quality of life. This study develops a novel foot-controlled hand/forearm exoskeleton that enables patients with hemiparetic hands and forearms to restore their voluntary activities of daily living. Patients can accomplish dexterous hand/arm manipulation on their own with the assistance of a foot-controlled hand/forearm exoskeleton by utilizing foot movements on the unaffected side as command signals. The proposed foot-controlled exoskeleton was first tested on a stroke patient with a chronic hemiparetic upper limb. The testing results showed that the forearm exoskeleton can assist the patient in achieving approximately 107° of voluntary forearm rotation with a static control error less than 1.7°, whereas the hand exoskeleton can assist the patient in realizing at least six different voluntary hand gestures with a success rate of 100%. Further experiments involving more patients demonstrated that the foot-controlled hand/forearm exoskeleton can help patients in restoring some of the voluntary activities of daily living with their paretic upper limb, such as picking up food to eat and opening water bottles to drink, and etc. This research implies that the foot-controlled hand/forearm exoskeleton is a viable way to restore the upper limb activities of stroke patients with chronic hemiparesis.
Evaluation of particle‐based smoothed particle hydrodynamics boundary handling approaches in computer animation

Boundary handling is an important aspect of fluid simulation, and several boundary handling approaches exist in smoothed particle hydrodynamics (SPH), which have individual strengths and weaknesses. However, comparing different boundary handling approaches is challenging as there is no common basis for evaluations, that is, no universal set of experiments with quantitative evaluation across different methods, especially within computer animation where many evaluations rely mainly on visual perception. This article proposes a set of experiments to aid the evaluation of the main categories of fluid‐boundary interactions that are important in computer animation, that is, no motion (resting) fluid, tangential and normal motion of a fluid with respect to the boundary, and a fluid impacting a corner. We propose ten experiments, comprising experimental setup and quantitative evaluation with optional visual inspections, that are arranged in four groups which focus on one of the main category of fluid‐boundary interactions. We use these experiments to evaluate three particle‐based boundary handling methods, that is, pressure mirroring, pressure boundaries, and moving least squares pressure extrapolation, in combination with two incompressible SPH fluid simulation methods, namely IISPH and DFSPH, to establish a quantifiable relation between different combinations of boundary handling with simulation approaches and the main categories of fluid‐boundary interactions. Finally, we summarize all results in a rating table and show how our experiments can be used to determine the promising method for specific requirements regarding a given constellation of fluid‐boundary interaction.
ON THE THEORY OF STOCHASTIC EQUATIONS IN COMPONENTS OF SEMIMARTINGALES

The first part of the paper is devoted to the proof of the existence and uniqueness of strong solutions of stochastic equations in components of semimartingales with coefficients depending on the whole past. In the second part variants of the comparison theorem are obtained for strong solutions of stochastic equations in semimartingales. Bibliography: 16 titles.
Sparse factorization of finite element matrices using overlapped localizing solution modes

Local‐global solution (LOGOS) modes provide a computationally efficient framework for developing fast, direct solution methods for electromagnetic simulations. In this article, we demonstrate that the LOGOS framework yields fast direct solutions for finite element discretizations of the wave equation in two dimensions. For fixed‐frequency applications, numerical examples demonstrate that the memory and CPU complexities of the proposed solver are nearly linear. © 2008 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 1050–1054, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23298
CORNEAL TRANSPLANTATION AND THE ARTIFICIAL CORNEA

The clinical need for an alternative to donor corneal tissue has encouraged much interest in recent years. An artificial cornea whether it be bio-engineered or a synthetic keratoprosthesis must fulfill the functions of the cornea it replaces: transparent, refractive surface, protection, non-immunogenic. A wide range of implants and biomedical devices have been developed in an attempt to correct corneal blindness. Limitation of existing biomaterials are evident when reviewing keratoprosthesis surgery complications. These include infection, intraocular inflammation, retromembrane formation, inadequate interface seal thus epithelial downgrowth and glaucoma. Attempts to improve healing in such cases have involved using various polymers or tissues to surround the optic. The successes and failures of synthetic prostheses that have been implanted in humans is discussed. More recently, the idea of a bio-engineered cornea has arisen. Tissue-engineering involves the manipulation of cells using in vitro techniques to create a composite tissue, which could then be implanted in vivo. Corneal equivalents have been reconstructed from corneal cell lines. They already have their potential uses in the biomedical world: as replacements for animals in toxicology testing and pharmacological studies, as well as in basic research into cell-cell and cell-matrix interactions of corneal wound healing. Current research is ongoing to determine if the bio-engineered cornea will have a role in corneal transplant surgery.
Validation of European Society of Cardiology pre-test probabilities for obstructive coronary artery disease in suspected stable angina

Abstract Aims To assess contemporary pre-test probability estimates for obstructive coronary artery disease in patients with stable chest pain. Methods and results In this substudy of a multicentre randomized controlled trial, we compared 2019 European Society of Cardiology (ESC)-endorsed pre-test probabilities with observed prevalence of obstructive coronary artery disease on computed tomography coronary angiography (CTCA). We assessed associations between pre-test probability, 5-year coronary heart disease death or non-fatal myocardial infarction and study intervention (standard care vs. CTCA). The study population consisted of 3755 patients (30–75 years, 46% women) with a median pre-test probability of 11% of whom 1622 (43%) had a pre-test probability of >15%. In those who underwent CTCA (n = 1613), the prevalence of obstructive disease was 22%. When divided into deciles of pre-test probability, the observed disease prevalence was similar but higher than the corresponding median pre-test probability [median difference 2.3 (1.3–5.6)%]. There were more clinical events in patients with a pre-test probability >15% compared to those at 5–15% and <5% (4.1%, 1.5%, and 1.4%, respectively, P < 0.001). Across the total cohort, fewer clinical events occurred in patients who underwent CTCA, with the greatest difference in those with a pre-test probability >15% (2.8% vs. 5.3%, log rank P = 0.01), although this interaction was not statistically significant on multivariable modelling. Conclusion The updated 2019 ESC guideline pre-test probability recommendations tended to slightly underestimate disease prevalence in our cohort. Pre-test probability is a powerful predictor of future coronary events and helps select those who may derive the greatest absolute benefit from CTCA.
Band tailing and efficiency limitation in kesterite solar cells

We demonstrate that a fundamental performance bottleneck for hydrazine processed kesterite Cu2ZnSn(S,Se)4 (CZTSSe) solar cells with efficiencies reaching above 11% can be the formation of band-edge tail states, which quantum efficiency and photoluminescence data indicate is roughly twice as severe as in higher-performing Cu(In,Ga)(S,Se)2 devices. Low temperature time-resolved photoluminescence data suggest that the enhanced tailing arises primarily from electrostatic potential fluctuations induced by strong compensation and facilitated by a lower CZTSSe dielectric constant. We discuss the implications of the band tails for the voltage deficit in these devices.
Exosome-based cancer vaccine for prevention of lung cancer

Background Our earlier work has shown that a unique stem cell-based vaccine that comprises of murine embryonic stem cells (ESCs) and murine fibroblasts expressing the immunostimulant granulocyte-macrophage colony stimulating factor (GM-CSF) successfully protects mice from the outgrowth of an implantable form of murine lung cancer. The use of live ESCs raises the potential risks of inducing teratomas and autoimmunity. We have attempted to improve the safety and utility of this prophylactic vaccine by employing exosomes derived from murine ESCs engineered to produce GM-CSF (ES-exo/GM-CSF vaccine). Methods We have previously reported that ES-exo/GM-CSF immunization does protect mice from the outgrowth of an implantable form of murine lung cancer. Here, we have investigated the cancer prevention efficacy of ES-exo/GM-CSF vaccine in an experimental metastasis model of murine lung cancer, in which Lewis lung carcinoma (LLC) cells were administered into female C57BL/6 mice (8 weeks of age) through tail vein injection and subsequently LLC tumors were established in lungs. Results Our objective is to test the anti-cancer efficacy of ES-exo/GM-CSF vaccine in a mouse model of metastatic lung cancer. Our studies indicate that vaccination of mice with ES-exo/GM-CSF vaccine inhibited the growth of metastatic lung tumors. ES-exo/GM-CSF vactionation reduced lung tumor burden from 1.86% in non-vaccinated, LLC-challenged mice to 0.036% in corresponding vacinnated mice. Importantly, control exosomes without GM-CSF failed to provide protection against metastasized pulmonary tumors. The efficacy of ES-exo/GM-CSF vaccination was associated with a decrease in the frequencies of tumor-infiltrating immunosuppressive immune cells, including T regulatory cells, myeloid derived suppressor cells (MDSCs) and tumor-associated macrophages, as well as an increase in effector cytokine production from intra-tumoral CD8+ T cells. Conclusions Overall, our research provides a novel strategy for developing a cell-free prophylactic vaccine against lung tumors.
Probing galactic dark matter in dense environments: on the strong lensing efficiency of galaxies in rich clusters

The recent detection by Limousin et al. of five new strong lensing events dominated by galaxy cluster members in Abell 1689, and outside the critical regime of the cluster itself, offers a way to obtain constraints on the cluster mass distribution in a region inaccessible to standard lensing analysis. In addition, modelling such systems will provide another window on the dark matter haloes of galaxies in very dense environments. Here, it is shown that the boost in image separation due to the external shear and convergence from a smooth cluster component means that more numerous, less massive galaxies have the potential to create multiple images with detectable separations, relative to isolated field galaxies. This comes in addition to a potential increase in their lensing (source plane) cross-section. To gain insight into the factors involved and as a precursor to a numerical study using N-body simulations, a simple analytic model of a cluster at z = 0.3 lensing background galaxies at z = 2 is considered here. The fiducial model has cluster members with isothermal density profiles and luminosities L, distributed in a Schechter function (faint-end slope v =-1.25), related to their velocity dispersions a via the Faber-Jackson scaling L α σ 4 . Just outside the critical regime of the cluster, the scale of galaxy-dominated image separations is significantly increased. Folding in the fact that less massive galaxies present a lower lensing cross-section, and that the cross-section can itself be enhanced in an external field leads to a factor of a few times more detected events relative to field galaxies. These values will be higher closer to the critical curve. Given that the events in Abell 1689 were detected over a very small region of the cluster where ACS data were available, this motivates the search for such events in other clusters.