Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of Antiphospholipid Antibodies on Intracytoplasmic Sperm Injection Outcome

Introduction and Aim: The effect of antiphospholipid syndrome on pregnancy is extensively discussed but the debate is still ongoing. This debate increased when the association was examined after assisted reproductive techniques for infertility. The current work aimed to evaluate the influence of Antiphospholipid antibodies in patient undergo first cycle of intracytoplasmic sperm injection. Subjects and Methods: The study comprised 130 of infertile females, who were scheduled for the first ICSI cycle. Before protocol selection, basal hormonal assay was performed and included FSH, LH, E2, prolactin and AMH. Plasma concentration of anti-phospholipids (APAs) was measured. Then, females were categorized into groups according to APAs (positive and negative groups). After ICSI, the clinical pregnancy was confirmed by presence the gestational sac or sac with positive pulsation. Ongoing pregnancy was recognized if the pregnancy continued after 12 weeks of the gestation and clinical miscarriage if pregnancy terminated before 12 weeks of gestation. Results: All females were in their reproductive age (18- 40 years). Their fertility duration ranged between 1 and 7 years, and it was of primary type among 96 women. The long agonist protocol was used for 72 women and the antagonist protocol done for 58 women. The Antiphospholipid antibodies were positive among 27 females (20.8%), and there was no significant difference between APL positive and negative groups regarding pregnancy results (either chemical, clinical, incidence of abortion or ongoing pregnancy after 12 weeks) for all females. However, in women with positive clinical pregnancy, the rate of abortion was significantly increased in patients with APL- positive than negative females (66.7% vs 26.7%). Conclusion: The presence of APA was associated with higher significant abortion rate after the first cycle of ICSI. Thus, screening for APA in women with infertility scheduled for assisted reproduction is recommended.
Force rearrangements and statistics of hyperstatic granular force networks

The heterogeneous force networks in static granular media --- formed from contact forces between grains and spanning from boundary to boundary in the packing --- are distinguished from other network structures in that they must satisfy constraints of mechanical equilibrium on every vertex/grain. Here we study the statistics of ensembles of hyperstatic frictionless force networks, which are composed of more forces than can be determined uniquely from force balance. Hyperstatic force networks possess degrees of freedom that rearrange one balanced network into another. We construct these rearrangements, count them, identify their elementary building blocks, and show that in two dimensions they are related via duality to so-called floppy modes, which play an important role in many other aspects of granular physics. We demonstrate that the number of rearrangements governs the macroscopic statistical properties of the ensemble, in particular the macroscopic fluctuations of stress, which scale with distance to the isostatic point. We then show that a maximum entropy postulate allows one to quantitatively capture many features of the microscopic statistics. Boundaries are shown to influence the statistics strongly: the probability distribution of large forces can have a qualitatively different form on the boundary and in the bulk. Finally, we consider the role of spatial correlations and dimension. All predictions are tested against highly accurate numerical simulations of the ensemble, performed using umbrella sampling.
Impact of 60 days of head-down bed rest on large arteries

Background: The long-term cardiovascular consequences of microgravity on large arteries are a threat for long-term space missions. We hypothesized that changes in arterial properties differ according to the arterial territory (upper or lower body), and arterial structure (elastic vs. muscular arteries), in response to 60-day head-down bed rest (HDBR). Method: Twenty healthy male volunteers were included and received a daily multivitamin supplementation in a double-blind fashion. At baseline, 29 and 52 days during strict HDBR, then 12 and 30 days after HDBR, aortic stiffness was measured using carotid-to-femoral pulse wave velocity (cf-PWV) and aortic MRI. Carotid, femoral, brachial and popliteal arteries were studied by ultrasound echo tracking, central blood pressure (BP) by tonometry and endothelial function by flow-mediated dilatation. Results: Cf-PWV increased during HDBR (+0.8 and +1.1m/s, at D29 and D52, respectively, P = 0.004), corresponding to an increase in vascular age up to +11 years (P = 0.003). Changes were similar to those observed on MRI (+0.8 m/s at D52, P < 0.01) and were independent of BP and heart rate changes. After HDBR, cf-PWV showed a substantial recovery at R12 but still remained higher than baseline at R30 (+0.8 m/s, P = 0.018), corresponding to +6.5 years of vascular aging (P = 0.018). Thoracic aorta diameter increased significantly (+6%, P = 0.0008). During HDBR, femoral and popliteal arteries showed dimensional changes, leading to femoral inward hypotrophic remodeling (femoral diameter: −12%, P < 0.05; wall cross-sectional area: −25%, P = 0.014) and popliteal inward eutrophic remodeling (popliteal diameter: −25%, P < 0.05; wall cross-sectional area: −3%, P = 0.51). After HDBR, both arterial territories of the leg recovered. We did not observe any significant changes for carotid arteries nor for endothelial function during and after HDBR. Multivitamin supplementation did not affect vascular changes. HDBR was associated with an important increase in aortic stiffness, which did not completely recover 1 month after the end of HDBR. The thoracic aorta and the lower body muscular arteries underwent significant changes in dimensions whereas the common carotid arteries were preserved. Conclusion: These results should raise caution for those exposed to microgravity, real or simulated.
PELVIC MASSES IN FEMALE PATIENTS INTERPRETATION PITFALLS ON MSCT AND MR IMAGING

Summary Different conditions within the pelvis are presented with very few symptoms. Likewise, their imaging characteris-tics are usually non-specific, implying high chance of misinterpretation. The aim of this paper is to point to the misinterpretation possibilities in computed tomography (CT) and magnetic resonance (MR) studies of the pelvic lesions and to outline their differential diagnosis. CT (11), MR (seven) or both (four patients) were performed in 22 female patients (age 23-69) with suspicious pelvic masses. Relevant laboratory and medical history data were available for most of the patients. Twenty patients underwent subsequent surgery and pathological findings were available in 18 cases. After radiological examinations different diagnoses were proposed in respect to imaging findings and available clinical data: pelvic inflammatory disease (one), ovarian tumor (six), uterine tumor (eight), metastatic or recurrent tumor (four), lymphocele (one), and post-irradiation and post-chemotherapy changes (two) patients. Postoperative results of the pathological analysis differed from radiological diagnosis in three of 18 pathologically examined materials: one benign tumor was falsely characterized as possibly malignant by the radiologist, one surgically transposed ovary was described as tumor, and one case of post-irradiation changes was described as recurrent tumor. Aside from knowing imaging characteristics, it is of great importance for radiologists to be aware of clinical, laboratory, and surgical protocols information as well as to have insight in patients’ prior imaging material in order to be able to correctly interpret imaging findings of the pelvic lesions.
Lossless Audio Steganography based on Lifting Wavelet Transform and Dynamic Stego Key

This paper presents a new lossless audio steganography approach based on Integer-to-Integer Lifting Wavelet Transform (Int2Int LWT) and Least Significant Bits (LSBs) substitution. In order to increase the security level a simple encryption with adaptive key has been proposed. The experimental results show that this approach has excellent transparency (above 45 dB of signal to noise ratio) with fixed high embedding capacity (25% from the audio cover signal size) and full recovery for the hidden secret message. Furthermore, robustness tests show immunity of the method against additive noise and perceptual statistical analysis. The proposed hiding and recovery procedures are simple and symmetry; therefore it can be easily used for real-time covert communication.
Neuroanatomical correlates of system-justifying ideologies: a pre-registered voxel-based morphometry study on right-wing authoritarianism and social dominance orientation

System-justifying ideologies are a cluster of ideals that perpetuate a hierarchical social system despite being fraught with inequalities. Right-wing authoritarianism (RWA) and social dominance orientation (SDO) are two ideologies that have received much attention in the literature separately and together. Given that these ideologies are considered to be stable individual differences that are likely to have an evolutionary basis, there has yet to be any examination for volumetric brain structures associated with these variables. Here, we proposed an investigation of overlapping and non-overlapping brain regions associated with RWA and SDO in a sample recruited in Singapore. Indeed, it will be interesting to determine how RWA and SDO correlate in a country that proactively promotes institutionalized multi-culturalism such as Singapore. RWA and SDO scores were collected via self-report measures from healthy individuals (39 males and 43 females; age 25.89 ± 5.68 years). Consequently, voxel-based morphometry (VBM) whole brain and region of interest (ROI) analyses were employed to identify neuroanatomical correlates of these system-justifying ideologies. RWA and SDO scores were strongly correlated despite the low ideological contrast in Singapore's sociopolitical context. The whole brain analysis did not reveal any significant clusters associated with either RWA or SDO. The ROI analyses revealed clusters in the bilateral amygdala and ventromedial prefrontal cortex (vmPFC) that were associated with both RWA and SDO scores, whereas two clusters in the left anterior insula were negatively associated with only SDO scores. The study corroborates the claim of RWA and SDO as stable individual differences with identifiable neuroanatomical correlates, but our exploratory analysis suggests evidence that precludes any definitive conclusion based on the present evidence.
Some Integrals Involving the (Q sub M)-Function

Abstract : The detection probability for a nonfading signal present on M multiple observations and subjected to a quadratic combination of receiver matched-filter outputs is given by the (Q sub M)-function. In the report, several integrals of the (Q sub M-function are evaluated that aid in computing the performance in fading channels; direct numerical integration of the (Q sub M)-function, which is time-consuming, is therefore circumvented. Numerical evaluation of (Q sub M) is considered in another paper.
Protecting and Dynamically Generating Entanglement in a Two-Atom Two-Field-Mode Model

We analyze the time evolution of quantum entanglement in a model consisting of two two-level atoms interacting with a two-mode electromagnetic field for a variety of initial states. We study two different coupling schemes motivated by the forms that can arise due to atomic separation. We observe a variety of qualitative features such as entanglement sudden death, dynamical generation, protection, and transfer between subsystems. Our quantitative analysis shows that these cases with different couplings and initial states differ significantly in these qualitative features. The multifarious behaviors in these two-mode cases suggest the importance of considering atomic separation carefully for any model where two atoms interact with a common field.
Probing the integrated Sachs-Wolfe effect using embedded lens models

The photometry profile of the integrated Sachs-Wolfe (ISW) effect recently obtained by the Planck consortium by stacking patches of Cosmic Microwave Background (CMB) sky maps around a large number of cosmic voids, contains a cold ring at about half the void’s effective radius surrounded by a hot ring near the void’s boundary. The source of the temperature structure is assumed to be the ISW effect but the exact cause of the ringed structure is not currently well understood, particularly the outer hot ring. Numerical simulations have suggested that hot/cold ring structures can be produced by motions associated with nonlinear growths of cosmic structures whose gravitational potentials produce the ISW effect. We have recently developed the embedded lens theory and the Fermat potential formalism which can be used to model the ISW effect caused by intervening individual lens inhomogeneities evolving arbitrarily. This theory only requires knowledge of the void’s projected mass profile as a function of the passing CMB photons’ impact radius and the rate of change of that mass distribution at passage. We present two simple embedded void lens models with evolving mass densities and investigate the ISW effect caused by these lenses. Both models posses expanding mass shells which produce hot rings around central cold regions, consistent with the recent observations. By adding a small over-density at the void’s center we can produce the slight positive temperature excess hinted at in Planck’s photometric results. We conclude that the embedded lens theory and the Fermat potential formalism is well suited for modeling the ISW effect.
A New Model of Hemoglobin Oxygenation

The study of hemoglobin oxygenation, starting from the classical works of Hill, has laid the foundation for molecular biophysics. The cooperative nature of oxygen binding to hemoglobin has been variously described in different models. In the Adair model, which better fits the experimental data, the constants of oxygen binding at various stages differ. However, the physical meaning of the parameters in this model remains unclear. In this work, we applied Hill’s approach, extending its interpretation; we obtained a good agreement between the theory and the experiment. The equation in which the Hill coefficient is modulated by the Lorentz distribution for oxygen partial pressure approximates the experimental data better than not only the classical Hill equation, but also the Adair equation.
Does uterus volume affect the total laparoscopic hysterectomy outcomes?

Background/Aim: Increased uterus weight, high body mass index (BMI), and history of abdominal surgeries increase the risk of complications in total laparoscopic hysterectomy (TLH), similar to other types of surgery. However, there are conflicting reports about improving technology. This study aimed to retrospectively investigate the clinical features and postoperative results of TLH cases regarding uterine volume performed for benign reasons in our clinic. Methods: In this retrospective cohort study, 252 patients were included. The demographic data of all patients, including BMI, pre-operative uterine volumes, operation times, number of cesarean sections, history of lower abdominal operation, indications, pre-operative and postoperative hemoglobin differences, complications, length of hospital stay, and final pathologies were reviewed. The uterine volume was measured using the prolate ellipsoid formula before surgery, using the maximum length and anteroposterior and transverse diameters of the uterine corpus. The normal uterine volume with these measurements (8 cm long, 4 cm high, and 5 cm wide) was estimated as 83.2 cm3. The patients were classified into two groups according to uterine volume (normal volume ≤ 83.2 or above). Surgical outcomes of patients were compared between groups. Results: Two-hundred-fifty-two women were included in the study. The mean uterine volumes of groups 1 and 2 were 53.66 cm3 (2.25) and 296.33 cm3 (6.25), respectively. In group 1, the mean operation time was 111.14 (6) min, compared to 118.2 (3.06) min in group 2; there was no significant difference (P = 0.164). The mean postoperative hospital stays of groups 1 and 2 were 3.21 (0.15) and 3.34 (0.09) days, respectively, and there was no significant difference (P = 0.706). The mean blood loss values of groups 1 and 2 were 1.34 g/dl (0.19) and 1.16 g/dl 0.06), respectively. Conclusion: According to our results, TLH is a safe method even in patients with a larger uterus; operating time, blood loss, and postoperative hospital stays did not differ according to uterine volume.
Corporate Governance Practices and its Impact on Efficiency of Working Capital Management (A Case Study of Pakistan)

Purpose: Recent Financial crunch exposed, creative reporting and fake facts such as Enron and WorldCom enlightened Act (2002) towards positive rationalism efficacy of governance and financial management for any public listed enterprise around the globe. The intention of this investigates highlight the influence of governance control on the management of operational capital. Methodology: A sample was carefully chosen of 116 Pakistan manufacturing establishment from annual reports listed over (PSE) for a period of 11 years (from 2009-2020). Panel methods were employed to evaluate the variant in Regressand due to predictors. Findings: The result reveals enormous negative influence of governing body on the working capital efficacy. However, investigation came up with the understanding that governance might play very substantial starring role in taming the effectiveness of liquidity. Values: The disclosures are beneficial for financial executives, financiers, financial consultants, and other stakeholders.
Long noncoding RNA TMEM147-AS1 serves as a microRNA-326 sponge to aggravate the malignancy of gastric cancer by upregulating SMAD5

The abnormal expression of long noncoding RNAs (lncRNAs) is frequently observed in gastric cancer (GC) and considered an important driving force in GC progression. However, little is known regarding the involvement of TMEM147-AS1 in GC. Therefore, we examined TMEM147-AS1 expression in GC and determined its prognostic value. In addition, TMEM147-AS1 expression was depleted to identify the functional changes in response to TMEM147-AS1 deficiency. Using the cancer genome atlas dataset and our own cohort, we identified a strong expression of TMEM147-AS1 in GC. Increased TMEM147-AS1 levels in GC showed a significant association with poor prognosis. TMEM147-AS1 interference resulted in the inhibition of GC cell proliferation, colony-forming, migration, and invasion in vitro. Additionally, depletion of TMEM147-AS1 restricted the growth of GC cells in vivo. Mechanistically, TMEM147-AS1 functioned as a microRNA-326 (miR-326) sponge. Furthermore, SMAD family member 5 (SMAD5) was experimentally validated as the functional effector of miR-326. TMEM147-AS1 was demonstrated to sequester miR-326 away from SMAD5; consequently, knocking down TMEM147-AS1 downregulated SMAD5 levels in GC cells. The functional suppression of miR-326 or reintroduction of SMAD5 effectively reversed the attenuated behavior of GC cells caused by TMEM147-AS1 downregulation. In summary, TMEM147-AS1 exhibits tumorigenic activities in GC, which is likely the result of an altered miR-326/SMAD5 axis. Therefore, targeting TMEM147-AS1/miR-326/SMAD5 may represent a target for the treatment of GC.
EVOLUÇÃO HUMANA E O SURGIMENTO DO DIREITO: A CONTRIBUIÇÃO DE RODOLFO SACCO COM O CONCEITO DE DIREITO MUDO

Rodolfo Sacco utiliza o conceito de direito mudo para propor a possibilidade da existência de direito em sociedades humanas que ainda não possuem a linguagem, mas que já viviam em sociedades organizadas. Este direito surge como exigência de responder a problemas práticos e se encontra em um momento intermediário entre sociedades de primatas não humanos e as sociedades humanas modernas que já dominam a linguagem. A pesquisa tem como objetivo apresentar reflexões acerca das contribuições de Sacco para a história e surgimento do direito, através do conceito de direito mudo e utilizou o método dedutivo, por meio de pesquisa bibliográfica.
Modulation of Glycoprotein VI and Its Downstream Signaling Pathways as an Antiplatelet Target

Antiplatelet therapy aims to reduce the risk of thrombotic events while maintaining hemostasis. A promising current approach is the inhibition of platelet glycoprotein GPVI-mediated adhesion pathways; pathways that do not involve coagulation. GPVI is a signaling receptor integral for collagen-induced platelet activation and participates in the thrombus consolidation process, being a suitable target for thrombosis prevention. Considering this, the blocking or antibody-mediated depletion of GPVI is a promising antiplatelet therapy for the effective and safe treatment of thrombotic diseases without a significant risk of bleeding and impaired hemostatic plug formation. This review describes the current knowledge concerning pharmaceutical approaches to platelet GPVI modulation and its downstream signaling pathways in this context.
Teaching Essential EMG Theory to Kinesiologists and Physical Therapists Using Analogies Visual Descriptions, and Qualitative Analysis of Biophysical Concepts

Electromyography (EMG) is a multidisciplinary field that brings together allied health (kinesiology and physical therapy) and the engineering sciences (biomedical and electrical). Since the physical sciences are used in the measurement of a biological process, the presentation of the theoretical foundations of EMG is most conveniently conducted using math and physics. However, given the multidisciplinary nature of EMG, a course will most likely include students from diverse backgrounds, with varying levels of math and physics. This is a pedagogical paper that outlines an approach for teaching foundational concepts in EMG to kinesiologists and physical therapists that uses a combination of analogies, visual descriptions, and qualitative analysis of biophysical concepts to develop an intuitive understanding for those who are new to surface EMG. The approach focuses on muscle fiber action potentials (MFAPs), motor unit action potentials (MUAPs), and compound muscle action potentials (CMAPs) because changes in these waveforms are much easier to identify and describe in comparison to the surface EMG interference pattern (IP).