Miracle-dz/UniFAR-FTUs huggingface dataset:
CUTANEOUS INVOLVEMENT IN MULTIPLE MYELOMA AT AN UNUSUAL SITE: A RARE CASE REPORT

: Multiple myeloma is a rare cancer. According to the most recent data from the Surveillance, Epidemiology, and End Results (SEER) program, multiple myeloma is the second most common haematological malignancy in the U.S. (after non-Hodgkin lymphoma), constitutes 1% of all cancers and constitutes 2% of all cancer deaths. Cutaneous involvement of multiple myeloma during treatment period is uncommon with fewer described in literature. Moreover, metastatic cutaneous involvement at the sole of the foot during treatment period of a IgA kappa type multiple myeloma patient followed by death has not encountered in literature. We have reported such a case.
Towards 3+1 Neutrino Mixing

We present an update of our analysis of short-baseline neutrino oscillation data in the framework of 3+1 neutrino mixing taking into account the recent update of MiniBooNE antineutrino data and the recent results of the MINOS search for nu_mu disappearance into sterile neutrinos (the more complicated 3+2 neutrino mixing is not needed since the CP-violating difference between MiniBooNE neutrino and antineutrino data has diminished). The results of our fits of short-baseline neutrino oscillation data including the MiniBooNE low-energy anomaly (now present both in the neutrino and antineutrino data) leads to a strong tension between appearance and disappearance data. Hence, it seems likely that the low-energy anomaly is not due to nu_mu -> nu_e transitions. Excluding the MiniBooNE low-energy anomaly, appearance and disappearance data are marginally compatible. The global analysis has the best-fit point at Delta m^2_{41} about 5.6 eV^2, which is rather large in comparison with cosmological bounds, but there are three regions within 1 sigma at Delta m^2_{41} about 1.6, 1.2, 0.91 eV^2. We also show that the data on the Gallium neutrino anomaly favor values of Delta m^2_{41} larger than about 1 eV^2.
iTweet about #Privacy Mapping Privacy Frames in Twitter Conversation

— Adopting a pragmatic bottom-up approach, the current study applies semantic network analysis and discourse analysis to unfold individual frames of privacy emerging in Twitter. To do so, the author collected and analyzed 100,000 publicly available Tweets selected using the word “privacy. ” The following two overarching questions guided the study: What are the frames that emerge in relation to privacy on Twitter? How are these frames discussed? Through a mixed method approach, the author identified the following nine frames of privacy: Privacy and Technology, Personal Privacy, Legal Privacy, Fundamental Privacy, Privacy Concerns, Spatial Privacy, Gossip, Trading Privacy, and Expected Flow of Information. The author also developed robust dictionaries to automate frame detection. In a future step, the author plans to use these dictionaries of privacy to analyze larger corpora of text and reach a meaningful understanding of how individuals frame privacy in everyday conversation.
Pharmacologic Metabolic Modulation in Severe Burn Injury: A Review of the Literature for Oxandrolone and Propranolol

Severe burn injury is associated with a significant hypermetabolic and hypercatabolic response that results in an increase in resting energy expenditure up to twice normal. Consequences of hypermetabolism include lean muscle mass loss and delayed wound healing. Many interventions have been shown to attenuate this metabolic response including early excision and grafting, temperature regulation of the environment, nutrition support, and physical therapy. Pharmacologic agents with proven benefits for metabolic modulation in severe burn injury include oxandrolone, a synthetic testosterone analog, and propranolol, a non-selective beta-adrenergic antagonist. The published literature for these agents will be presented and evaluated in this review, and recommendations for use in patients with severe burn injury will be provided.
Edinburgh Research Explorer Effective Caspase Inhibition Blocks Neutrophil Apoptosis and Reveals Mcl-1 as Both a Regulator and a Target of Neutrophil Caspase Activation

: Inthemammalianovaryasmallnumberoffolliclesaresteadilyrecruitedfromthequiescentpooltoundergodevelopment.Follicle loss, maintenance and growth are strictly controlled by complex molecular interactions including the phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt) signalling pathway. Stimulation of PI3K promotes phosphorylation of Akt resulting in follicle survival and activation of growth whereas this pathway is suppressed by the actions of the phosphatase and tensin homologue (PTEN). The aim of this study was to determine the effectofdipotassium bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate(bpV), areversibleinhibitorofPTEN,on theactivation,survival and development of human ovarian follicles in vitro . Biopsied ovarian tissue fragments were obtained from 17 women aged 23–46 years and exposed to 1 m M bpV(HOpic) ( n ¼ 146) or control medium ( n ¼ 128) for 24 h. Media were then replaced with control medium and all tissue incubated for a further 5 days. Ovarian tissue from each treatment group was ﬁxed after the initial 24 h culture period and phosphorylated Akt was quantiﬁed by western blotting. After 6 days incubation all tissue fragments were inspected under light microscopy and any secondary follicles ≥ 100 m m isolated. Isolated follicles were cultured individually in control medium supplemented with 100 ng/ml recombinant human activin A. Tissue fragments without follicles suitable for isolation were ﬁxed and processed for histological and immunohistochemical analysis. During 6 days culture, follicle activation occurred in tissue samples from both treatment groups but with signiﬁcantly more follicles progressing to the secondary stage of development in the presence of 1 m M bpV(HOpic) compared with control (31 versus 16%; P , 0.05). Increased ac-tivationwasassociatedwithincreasedAktphosphorylationandincreasednuclearexportofFOXO3.Howeverisolatedandculturedfolliclesthat had been exposed to bpV(HOpic) showed limited growth and reduced survival compared with follicles from control fragments ( P , 0.05). This study demonstrates that inhibition of PTEN with bpV(HOpic) affects human ovarian follicle development by promoting the initiation of follicle growth and development to the secondary stage, as in rodent species, but severely compromises the survival of isolated secondary follicles. compared by one-way ANOVA with subsequent t -tests. Proportional data were compared using chi-squared analysis and Fishers Exact test.
DEVELOPMENT OF MEDICAL NOMENCLATURE AND ALGORITHMS FOR DIAGNOSIS AND TREATMENT OF GOUT IN OUTPATIENT SETTINGS

the diagnosis and selecting adequate therapy. The cornerstone of an expert system is a knowledge base. The aim of this paper was to develop a medical nomenclature and algorithms for the diagnosis and treatment of gout that will be used to create an expert system in the future. A total of 1,174 entities were selected that laid the basis for 40 diagnostic and 50 treatment algorithms for gout patients. All informational models were verified by the expert panel. Author contribution: Osmolovsky IS built and performed technical verification of the medical nomenclature and algorithms for the diagnosis and treatment of gout, analyzed information provided by the expert panel, wrote the technical section of the paper and prepared figures and tables; Zarubina TV proposed the design of the study, supervised the study, analyzed information provided by the expert panel and performed technical verification of the informational objects; Shostak NA, Kondrashov AA, Klimenko AA collected data for the informational objects, performed clinical verification of the informational objects and wrote the clinical section of this paper. Compliance ethical standards: the study was by the Ethics Committee of Pirogov National Research Medical University (Protocol № 192 dated January 27, 2020).
A Long Haul Carrier Generated Ultra Dense Passive Optical Network Incorporating Low Cost VCSEL

: An ultra-dense WDM passive optical network is proposed at 6.25 GHz channel spacing. A low cost VCSEL laser is incorporating in the system for the generation of multiple wavelengths. Results revealed that proposed system can successfully achieve 120 km in both optical line terminal (OLT) and optical network unit (ONU) at 2.5 Gbps.
(cid:1) 9 and (cid:2) 2CDR3 domains regulate functional avidity of T cells harboring 2TCRs

Immunotherapy with innate immune cells a for as an innate with high frequency and strong antitumor reactivity, promising candidates for immune inter-ventions. only limited control by adoptively transferred (cid:1) 9 (cid:2) 2T cells. As a potential explanation for this lack of efﬁ-cacy,wefoundunexpectedlyhighvariabil- ity in tumor recognition within the physiologic human (cid:1) 9 (cid:2) 2T-cell repertoire, which is substantially regulated by the CDR3 domains of individual (cid:1) 9 (cid:2) 2TCRs. In the present study, we demonstrate that the reported molecular requirements of CDR3 domains to interact with target cells shape the physiologic (cid:1) 9 (cid:2) 2T-cell repertoire and, most likely, limit the protective and therapeutic antitumor efﬁcacy of (cid:1) 9 (cid:2) 2T cells. Based on these ﬁndings, we propose combinatorial- (cid:1)(cid:2) TCR-chain exchange as an efﬁcient method for designing high-afﬁnity (cid:1) 9 (cid:2) 2TCRs that mediate improved antitumor responses when expressed in (cid:3)(cid:4) T cells both in vitro and in vivo in a humanized mouse model. ( Blood . 2012; 120(26):5153-5162)
Characterization of Murine Leukemia Virus Restriction in Mammals

Restriction of murine leukemia virus (MLV) was examined in cells from a range of mammals. All nonmurine restrictions were saturable blocks to N-tropic MLV infection, and several were prior to reverse transcription. We demonstrate restriction in cells from bat and show that if we express the murine restriction factor Fv1 in human cells, then Fv1, not the human host, deﬁnes the stage at which infection is blocked. Saturable blocks to retrovirus infection in cells from a wide range of mammals have recently been described to be active against both gamma retroviruses and lentiviruses (2, 7, 10, 14, 19, 21; reviewed in reference 4). These data indicate the exis-tence of dominant factors, termed Ref1 and Lv1, with charac-teristics similar to those of the murine restriction factor Fv1 (11). The Fv1 gene is derived from endogenous retroviral sequence with no signiﬁcant homology to murine leukemia virus (MLV) and is a dominant inhibitor of retroviral infection (3, 8, 17). Two Fv1 alleles allow the division of MLVs into N-tropic and B-tropic
Picowatt 0.5V Supply with 3ppm/ ◦ C CMOS Voltage Reference for Energy Harvesting System

: This paper presents a novel picowatt CMOS voltage reference for energy harvesting (EH) system applications.The output voltage is 133.6mV with subthreshold operations of MOSFETs at a supply of 0.5V. It was simulated in 0.18- µ m CMOS technology. The simulation results show voltage variation of 0.594%/V line sensitivity for supply voltage from 0.5V to 3V and about 3ppm/ ◦ C of temperature variation from -20 ◦ C to 80 ◦ C. Its power consumption is only 205.027pW. The power supply rejection ratio (PSRR) has been kept stably at -41.99 dB up to GHz level.
D 0 -Meson R AA in PbPb Collisions at √ s NN = 5.02 TeV and Elliptic Flow in pPb Collisions at √ s NN = 8.16 TeV with CMS

The study of charm production in heavy-ion collisions is considered an excellent probe for the properties of the hot and dense medium created in heavy-ion collisions. Measurements of D 0 -meson nuclear modiﬁcation factor can provide strong constraints into the mechanisms of in-medium energy loss and charm ﬂow in the medium. The measurement of D 0 -meson elliptic ﬂow in pPb collisions helps us understand the strength of charm quarks coupling to signiﬁcantly reduced systems which demonstrate hydrodynamic properties. In this paper, the measurements of the D 0 -meson nuclear modiﬁcation factor in PbPb collisions at 5.02 TeV together with the new measurement of D 0 -meson elliptic ﬂow in high multiplicity pPb collisions at 5.02 TeV using the two-particle correlation method will be presented. as strongly as light ﬂavor quarks. In addition, D 0 -meson v 2 in pPb is smaller than in PbPb collision. Finally, in the v 2 / n q vs KE T / n q plots, D 0 mesons have similar behavior to light ﬂavor hadrons scaled by the number of constituent quarks (NCQ) in PbPb while it is signiﬁcantly lower than strange hadrons in pPb, which again shows that charm quarks couple to small systems more weakly than light ﬂavor quarks.
Properties of fiberglass crossarm in transmission tower - a review

The main structure of the transmission line is the transmission tower. Transmission towers design must endure the weight of the trans-mission conductor at a certain height from ground. One of the main structures in transmission tower is crossarm. Crossarms of the trans-mission tower supports the transmission conductor. This paper is a review of past studies on fiberglass crossarm based on its mechanical properties and electrical performances. The aim of this paper is to analyze the mechanical properties which is including its tensile strength, elongation and hardness. It was discovered that the tensile strength increasing while hardness and elongation at break decreasing. In addition, the fiberglass has greater lightning power strength than the wood crossarm. It can be concluded that fiberglass crossarm can be used to replace conventional timber crossarm.
On The Packing Coloring Of Unicyclic Graph Family

: All graph in this paper is connected graph. Let   v u d , be a distance between any vertex u and v in graph  A function  is called a packing  k coloring if every two vertex of color i are at least distance   G p  or packing chromatics number of graph G is the smallest integer of k which has packing coloring. Unicyclic graphs are graphs that only have one cycle. This graphs is denoted by l C , which l is the length of the unicyclic graph. In this paper, we will study about packing  k coloring of graphs and determine their packing chromatic number. We have found the exact values of the packing coloring of unicyclic graph family.
C ustomer B ehaviour Segmentation among Mobile Service Providers in Kenya using K-Means Algorithm

In today’s competitive environment, operators are investing in understanding their customers better, especially their most profitable customer groups and the groups that have the biggest potential to become such. By segmenting customers based on their behavior, operators can better target their actions, such as launching tailored products and target one-to-one marketing, to meet the customer expectations. The general objective of the study is to provide customer behavior segmentation in mobile telecommunication markets using K-means Algorithm. The specific objectives include to handle multidimensionality data using K-means algorithm with Principal component analysis, to determine the value of parameter K (number of clusters) using stability plot before clustering, to use financial variables (mean monthly charges) for each frequently used service as inputs in k-means for Segmentation, to evaluate Clustering results and determine the most profitable segment using completely randomized design (CRD). The experiment to achieve the objectives was being done on R software. Results show that Cluster 3 and 1 are the most profitable segments. The operators often need to design distinguishable marketing strategy based on different behavior of their mobile subscribers in order to improve their marketing result and revenue.
APPRAISAL ANALYSIS TO DESIGN PROCESS: A CASE STUDY ON EDUCATION

This study examines the possibility, through an appraisals analysis, to qualify the experience of candidates for Master’s degrees in order to reduce their anxiety when it comes to choosing these programs. Using a theoretical and methodological approach based on Appraisals Theory, in-depth interviews were conducted with 20 people (interested in applying to Master’s in differ-ent areas), who reported anxiety when choosing their programs. Based on empirical results, it was possible to identify categories that were explored through the relationship with this theory. This analysis brought elements that have provided support for generating design guidelines in order to qualify the experiences of future Master’s degree students.
Effect of Link Design of Thin Cardiovascular Stent to Its Flexibility

Until recently, stent has been used effectively to open a cardiovascular blockage due to the plaque. Various designs of stent are available commercially in the marketplace. Thus, it was difficult to select the suitable stent that meets to the varying needs of the patient beyond the material, such as flexibility, inflated diameter, and radial strength. The present study would focus on finding the effect of link design to its flexibility, while the strut design was remained and the material was the same. The study was carried out by finite element modeling and software ABAQUS 6.13 was employed to perform the simulation. The metal alloy of Cobalt has been selected to be material of the stent model. A thin stent model consists of a pair of the strut which was connected by three links (L1, L2, L3) with a thickness of 60μm and 80μm frame wide. The model has a size of 1.237mm in outer diameter and 2mm long. The flexibility was expressed by the curvature index as the ratio of bending angle to stent length. The flexibility was performed at the bending moment concerning x-axis (Mxx) and y-axis (Myy). Results indicated that link design L1 performed the highest flexibility compared to other link designs which was indicated by the highest curvature index at the same value of bending moment (Mxx and Myy).
Isolation and Characterization of Symbiotic Mutants of Bradyrhizobium sp. (Arachis) Strain NC92: Mutants with Host-Specific Defects in Nodulation and Nitrogen Fixationt

Random transposon TnS mutagenesis of Bradyrhizobium sp. (Arachis) strain NC92, a member of the cowpea cross-inoculation group, was carried out, and kanamycin-resistant transconjugants were tested for their symbiotic phenotype on three host plants: groundnut, siratro, and pigeonpea. Two nodulation (Nod-phenotype) mutants were isolated. One is unable to nodulate all three hosts and appears to contain an insertion in one of the common nodulation genes (nodABCD); the other is a host-specific nodulation mutant that fails to nodulate pigeonpea, elicits uninvaded nodules on siratro, and elicits normal, nitrogen-fixing nodules on groundnut. In addition, nine mutants defective in nitrogen fixation (Fix- phenotype) were isolated. Three fail to supply symbiotically fixed nitrogen to all three host plants. Surprisingly, nodules elicited by one of these mutants exhibit high levels of acetylene reduction activity, demonstrating the presence of the enzyme nitrogenase. Three more mutants have partially effective phenotypes (Fix') in symbiosis with all three host plants. The remaining three mutants fail to supply fixed nitrogen to one of the host plants tested while remaining partially or fully effective on the other two hosts; two of these mutants are Fix- in pigeonpea and Fix'
Direct Torque and Predictive Control Strategies in Nine-Phase Electric Drives Using Virtual Voltage Vectors

One of the main distinctive features of multiphase machines is the appearance of new degrees of freedom (<inline-formula><tex-math notation="LaTeX">${\boldsymbol{x}}$</tex-math></inline-formula>–<inline-formula><tex-math notation="LaTeX">${\boldsymbol{y}}$</tex-math></inline-formula> voltages/currents) that do not exist in their three-phase counterparts. As a direct consequence, control approaches that apply a single switching state during the sampling period cannot achieve zero average <inline-formula><tex-math notation="LaTeX">${\boldsymbol{x}}$</tex-math></inline-formula>–<inline-formula><tex-math notation="LaTeX">${\boldsymbol{y}}$</tex-math></inline-formula> voltage production. In direct torque control (DTC) this implies that <inline-formula><tex-math notation="LaTeX">${\boldsymbol{x}}$</tex-math></inline-formula>–<inline-formula><tex-math notation="LaTeX">${\boldsymbol{y}}$</tex-math></inline-formula> currents are not regulated, whereas in finite-control-set model predictive control (FCS-MPC) an enhanced <inline-formula><tex-math notation="LaTeX">${\boldsymbol{x}}$</tex-math></inline-formula>–<inline-formula><tex-math notation="LaTeX">${\boldsymbol{y}}$</tex-math></inline-formula> current regulation is feasible only at the expense of disturbing the flux/torque production. Aiming to avoid these shortcomings, this work makes use of the concept of synthetic/virtual voltage vectors (VVs) to nullify/limit the <inline-formula><tex-math notation="LaTeX">${\boldsymbol{x}}$</tex-math></inline-formula>–<inline-formula><tex-math notation="LaTeX">${\boldsymbol{y}}$</tex-math></inline-formula> voltage production in order to improve the current regulation in the secondary planes. Two strategies using two and four virtual voltage vectors (2-VV and 4-VV, respectively) are proposed and compared with the standard case that applies a single switching state. Since standard MPC has the capability to indirectly regulate <inline-formula><tex-math notation="LaTeX">${\boldsymbol{x}}$</tex-math></inline-formula>–<inline-formula><tex-math notation="LaTeX">${\boldsymbol{y}}$</tex-math></inline-formula> currents, the improvements with the inclusion of VVs are expected to be more significant in DTC strategies. Experimental results validate the proposed VVs and confirm the expectations through a detailed performance comparison of standard, 2-VV and 4-VV approaches for DTC and MPC strategies.
PHYSICAL STATES ON A C*-ALGEBRA

Let A be a C*-algebra with identi ty 1. A physical state is a function Q: A-~C which is a state on each singly generated C*-subalgebra of A. Here "singly generated" means generated by 1 and a single self-adjoint element aEA. The present paper is devoted to a discussion of whether a physical state ~ on A is linear, i.e. whether it is a state in the ordina ry sense. In the proper physical interpretation, this is the problem of linearity of the expectation functional on the algebra of observables in quantum mechanics, ef. Mackey [8] and Kadison [6]. Mathematically, the problem is also closely related to the following problem: Let R be a yon Neumann algebra, and let P be the lattice of orthogonal projections in R. A function ~: p -+R+ such that/~(0) =0 is called a completely additive measure on P if
Chilli Grading and Maturity Stage Classification using Deep Learning Techniques.

As per the survey carried out, very less research work reported on machine vision for chilli grading and classification of chilli maturity stages. In the research work carried out, we propose a cost effective method to grade chilli based on post-harvest decisions and classify the chilli maturity stages using deep Convolution Neural Networks. The dataset consisting of 48,000 images of different prematurity and maturity chilli images is created. The variations in dataset to reflect, offset problems of occlusion and illumination conditions are also considered. The proposed chilli grading/classification model has obtained the accuracies of 89% and 97% respectively for different chilli varieties grading based on post-harvest grading decisions and chilli maturity stages
A review Biological control by Plant Growth Promoting Rhizobacteria

Plant Growth Promoter Rhizobacteria (PGPR) is soil bacteria that can live on, in or around plant tissue and promote plant growth by many mechanisms that include a biological control of plant pathogens. Indeed, PGPRs have a protective effect through several modes of action such as antagonism, competition, production of hydrolytic enzymes and biofilm formation. Moreover, the use of PGPRs as biocontrol agents is very harmonious with the environment and therefore represents a good alternative to the use of chemicals in agriculture. This review is presented as a general bibliographical synthesis on the different aspects of PGPRs and their biocontrol potential.