Miracle-dz/UniFAR-FTUs huggingface dataset:
Viewing AML through a New Lens: Technological Advances in the Study of Epigenetic Regulation

Simple Summary Epigenetic mechanisms regulate gene expression in each cell type without modifying the underlying genetic sequence. These mechanisms are crucial for normal blood cell function. When they are disrupted, they give rise to diseases such as acute myeloid leukemia, an aggressive type of blood cancer. In this review, we outline the most recent technological advances that enable the study of the epigenetic mechanisms of blood cells with greater precision and a higher resolution. From the technologies that can introduce specific types of epigenetic changes ((epi)-genomic editing) to those that allow us to study the epigenetic mechanisms of individual cells, we summarize the advances which provide a new lens through which to study epigenetic regulation. Given the essential role of epigenetic mechanisms in healthy tissue function and disease, this can provide a comprehensive resource for researchers in the gene regulation field and beyond. Abstract Epigenetic modifications, such as histone modifications and DNA methylation, are essential for ensuring the dynamic control of gene regulation in every cell type. These modifications are associated with gene activation or repression, depending on the genomic context and specific type of modification. In both cases, they are deposited and removed by epigenetic modifier proteins. In acute myeloid leukemia (AML), the function of these proteins is perturbed through genetic mutations (i.e., in the DNA methylation machinery) or translocations (i.e., MLL-rearrangements) arising during leukemogenesis. This can lead to an imbalance in the epigenomic landscape, which drives aberrant gene expression patterns. New technological advances, such as CRISPR editing, are now being used to precisely model genetic mutations and chromosomal translocations. In addition, high-precision epigenomic editing using dCas9 or CRISPR base editing are being used to investigate the function of epigenetic mechanisms in gene regulation. To interrogate these mechanisms at higher resolution, advances in single-cell techniques have begun to highlight the heterogeneity of epigenomic landscapes and how these impact on gene expression within different AML populations in individual cells. Combined, these technologies provide a new lens through which to study the role of epigenetic modifications in normal hematopoiesis and how the underlying mechanisms can be hijacked in the context of malignancies such as AML.
Factors Affecting Patient Satisfaction in Dermatology Clinics in Saudi Arabia

Background A methodical approach to health services called “quality of care” places an emphasis on both interpersonal and technical competence in the delivery of medical care. One of the key elements of high-quality care is the client's or patient's satisfaction, which includes treating them with respect, being aware of their needs, and meeting those needs. Dermatologists are forced to expand service availability and respond to patients' needs and desires as required through satisfaction surveys as a result of an increase in the number of insured patients and demand for services. Methods A cross-sectional study was conducted in Saudi Arabia to measure patient satisfaction with the medical care provided to patients in dermatology clinics affiliated with the government and private hospitals by recording the responses received from a questionnaire assessing the doctor’s attitude, such as whether the dermatologist was punctual and had the patient’s medical records. The modified Arabic language digitally administered questionnaire with 17 closed-ended items was used to collect data from respondents. Results In total, 1002 patients, including 70.76% females and 29.24% males, participated in the study; 83.33% of patients visited a dermatology clinic of which 74.61% visited private clinics, and the disease had already developed in 64.55% of patients. A 5-point Likert scale with six statements was used to measure patient satisfaction with the visiting doctor. Overall, the mean score was very high (4.41 ± 0.92). Conclusion According to the results of this study, respect for patients’ wishes, emotional support, and physical comfort appear to be the most crucial factors in determining patient happiness. Healthcare systems should strive to achieve a balance in services that not only offer clinically effective care but are also perceived by the patients as acceptable and beneficial. This is true regardless of demographic status.
Kualitas Akrual: Kebutuhan Stakeholder dan Konsekuensi Ekonomi

This study aims to examine the quality of accrual having economic consequences in predicting future cash flows in manufacturing companies listed on the Indonesia Stock Exchange (IDX) for the 2017-2019 period. The population in this study were all manufacturing companies listed on the Indonesia Stock Exchange (IDX), the research sample was determineted using the pusposive sampling method with a total sample of 213 companies. The data used is secondary data from the company’s annual report. The analytical method used i multiple regression analysis (MRA). The result showed that the interest of investors and the interest of lenders were positively correlated with the quality of accruals. Suppliers interest is negatively correlated with accrual quality. While the quality of accruals has economic consequences in predicting future cash flows.
Multifocus image fusion using Zernike moments

A multifocus image fusion method using orthogonal moments is presented. The focus measure is based in the compute of Zernike and Harmonic moments of an image function. The algorithm divides the input images into blocks and evaluate the contrast of each block. From this, the boundaries between focused and defocused regions have been determined. The method selects the better focused regions to create the final focused image. The method is based on orthogonal basis functions, which are used as moment weighting kernel. Fusion results show that, Zernike-Fourier moments can achieve a high quality fusion. However, Harmonics moments achieve a good fusion with a simple average of moments.
The Pistol Star

We present new near-infrared data and analysis, which indicate that the Pistol Star is one of the most luminous stars known, adding another test point for massive star formation and stellar evolution theories. We estimate an extinction of AK = 3.2 ± 0.5 using the near-infrared colors of the star and of surrounding stars in the young Quintuplet cluster. Using our wind/atmosphere code, we find two families of models that fit the spectral energy distribution and detailed line profiles. The lower luminosity models give L = 106.6±0.2 L☉ and Teff = 104.15±0.01 K, while the higher luminosity models give L = 107.2±0.2 L☉ and Teff = 104.33±0.01 K; the error in luminosity assumes an uncertainty of ±0.5 in AK, while the error in Teff is constrained by detailed line modeling. The models also reveal a helium enriched surface. As previously existing stellar evolution models do not extend to such high luminosities, we employ new evolutionary tracks for very massive stars to determine the initial mass and age of the Pistol Star, and estimate Minitial = 200-250 M☉ and an age of 1.7-2.1 Myr. The inferred luminosity and temperature place the star in a sparsely populated zone in the H-R diagram where luminous blue variables (LBVs) are often found. This is consistent with our evolutionary models, which predict that the star is in an unstable evolutionary stage. We interpret the star and its surrounding nebula as an LBV that has recently ejected large amounts of material. Our K-band speckle-imaging data reveal the star to be single down to a projected separation of 110 AU.
16 Years (2006–2021) of Surface Ozone Measurements in Córdoba (Southern Spain): Trends and the Impact of the COVID-19 Lockdown

Surface ozone concentrations (O3) during the period 2006–2021 are analysed at Córdoba city (southern Iberian Peninsula) in suburban and urban sampling sites. The aims are to present the levels and temporal variations, to explore trends and to quantity the variation in O3 concentrations in the context of the COVID-19 lockdown. The O3 means are higher in the suburban station (62 µg m−3 and 51.3 µg m−3), being the information level threshold only exceeded twice during this period. The daily evolution shows a maximum at about 17:00 UTC, whereas the minimum is reached at about 9:00 UTC, with higher levels in the suburban station. The seasonal evolution of this daily cycle also presents monthly differences in shape and intensity between stations. The trends are analysed by means of daily averages and daily 5th and 95th percentiles, and they show a similar increase in all of these parameters, with special emphasis on the daily P95 concentrations, with 0.27 µg m−3 year−1 and 0.24 µg m−3 year−1. Finally, the impact of the COVID-19 lockdown shows a decline in O3 concentrations over 10%.
Effects of polarization field on vertical transport in GaN/AlGaN resonant tunneling diodes

Polarization-field effects on the vertical transport in GaN/AlGaN resonant tunneling diodes (RTDs) were theoretically investigated by using the transfer matrix formalism. The self-consistent model shows that the resonant peaks are shifted toward higher energies with increasing Al composition in the AlGaN barrier, and the transmission probability values are shown to decrease rapidly. In the case of the flat-band model, on the other hand, the shift of the resonant peaks is smaller than it is for the self-consistent model and the variation of transmission probability values with increasing Al composition is relatively smaller than that of the self-consistent model. The current-voltage characteristics of the self-consistent model are asymmetric while those of the flat-band model are symmetric for positive and negative current directions. The peak-to-valley ratio (PVR) of the self-consistent model is shown to be slightly smaller than that of the flat-band model for Al = 0.3.
The AKNS hierarchy as symmetry constraint of the KP hierarchy

The quantity psi psi * formed by the KP eigenfunctions and adjoint eigenfunctions is discussed as a symmetry generator. The constraint of ( psi psi *)x to the simplest symmetry ux gives a new interrelation between the KP and the AKNS hierarchies, namely the hierarchy of the KP auxiliary linear problems is reduced to the standard AKNS hierarchy. As a result the authors obtain a submanifold of the KP solution space by AKNS flows. This relation corresponds to the well known relation between soliton equations in 1+1 dimensions and finite-dimensional integrable systems.
Corner flow in the sliding plate problem

The usual formulation of the well‐studied sliding plate problem of driven cavity flow involves an unphysical boundary velocity discontinuity at the corners where moving and fixed boundary surfaces intersect. Molecular dynamics simulations of a Lennard‐Jones liquid in a cavity driven by the motion of realistic atomic walls at several Reynolds numbers are used to explore the small‐scale structure of this flow. The results indicate that slip occurs in the corner region, removing the stress singularity which would otherwise occur, and furthermore that the fluid has non‐Newtonian behavior there. Elsewhere, at least at low Reynolds numbers, the overall flow field is consistent with continuum calculations which do not allow for slip. As the Reynolds number increases, the slip region grows in size, and eventually extends across the entire moving boundary. The often‐cited Navier slip boundary condition is shown to be incorrect. The mechanism for the avoidance of singular behavior here is generally similar to that .
Introduction to the physics of rocks

Preface and AcknowledgmentsIRocks3IIPorous Media17IIIHeterogeneous Media53IVMechanical Behavior of Dry Rocks73VCirculation of Fluids: Permeability117VIMechanical Behavior of Fluid-Saturated Rocks135VIIAcoustic Properties159VIIIElectrical Conductivity182IXDielectric Properties212XThermal Conductivity254XIMagnetic Properties278Index293
HiFLO: a high-throughput system for spatial analysis of FISH loci in interphase nuclei

Numerous investigations in the last years focused on chromosome and gene arrangements through the application of statistical methods that analyze the non randomness of spatial distributions of fluorescence in situ hybridization (FISH) labeled nucleic acid sequences in terms of their distance to the nuclear centers and their proximity to each other. However, existing imaging processing methods are rather limited in extracting sufficient number of nuclei with FISH label sequences, and manual analysis is unreasonably time-consuming and subjective. This paper presents an automated system that integrates a series of advanced image processing methods to over come this rate-limiting step. Evaluation results show that the proposed method is efficient, robust, and effective in extracting individual nuclei with FISH labels.
Resolving Power and Information

The degrees of freedom of an image formed by any real instrument are only a finite number, while those those of the object are an infinite number. Several different objects may correspond to the same image.It is shown that in the case of coherent illumination a large class of objects corresponding to a given image can be found very easily. Two-point resolution is impossible unless the observer has a priori an infinite amount of information about the object.
The effect of Reynolds number on the scaling range along the centreline of a round turbulent jet

In this paper, the effect of Reynolds number on the scaling range of the velocity spectra and structure functions along the centreline in a round turbulent jet is considered. Hot-wire measurements were taken over a range of exit Reynolds numbers (). Both axial (u) and transverse (v) energy spectra in the scaling range demonstrate considerable departure from the k−5/3 (Kolmogorov inertial range scaling). Over the present range of Reynolds numbers, the scaling wave number exponent for axial, m1, and transverse, m2, spectra exhibit monotonic changes with Taylor Reynolds number: , . On the jet centreline, the data are in close agreement with the earlier findings for grid-generated turbulence. In addition, the structure functions are investigated. The scaling exponent for the second-order structure functions increases with in a power-law fashion () similar to the spectra. The peak value of the normalised third-order structure function C3 asymptotically approaches 4/5 as the Reynolds numbers increases: . The present round jet data confirm that a proper inertial range is unlikely to be established along the jet axis unless a very high Reynolds number of can be reached.
Defect evaluation in InGaAs field effect transistors with HfO2 or Al2O3 dielectric

The performance of InGaAs metal oxide semiconductor field effect transistors with Al2O3 or HfO2 as gate oxide is evaluated and compared. The Al2O3 transistors show the lowest subthreshold slope and mid gap Dit, however, the HfO2 transistors reach a higher maximum transconductance (gmax) due to the higher oxide capacitance. Both high-κ dielectrics show a gm-frequency dispersion due to tunneling into border traps with a negligible activation energy as determined from temperature dependent measurements. The total amount of trapped charge at border traps is lower in the HfO2 devices. Scaling the HfO2 thickness further reduces the gm-frequency dispersion, possibly due to detrapping to the gate electrode.
PLLA Composites Combined with Delivery System of Bioactive Agents for Anti-Inflammation and Re-Endothelialization

The development of a biodegradable vascular scaffold (BVS) for the treatment of cardiovascular diseases (CVDs) still requires some improvement. Among them, re-endothelialization and anti-inflammation are clinically important to restore vascular function. In this study, we proposed a coating system to deliver hydrophilic bioactive agents to BVS using nanoemulsion and drop-casting methods. The poly(L-lactide) (PLLA) scaffold containing magnesium hydroxide (MH) was coated on the surface with bioactive molecules such as polydeoxyribonucleotide (PDRN), L-arginine (Arg, R), and mesenchymal stem cell-derived extracellular vesicles (EVs). PDRN upregulates the expression of VEGF as one of the A2A receptor agonists; and Arg, synthesized into nitric oxide by intracellular eNOS, induces endothelialization. In particular, EVs, which are composed of a lipid bilayer and transfer bioactive materials such as protein and nucleic acid, regulate homeostasis in blood vessels. Such a bioactive agent coating system and its PLLA composite suggest a new platform for the treatment of cardiovascular dysfunction.
Spatial and seasonal variability of CO 2 flux at the air-water interface of the Three Gorges Reservoir

Diffusive carbon dioxide (CO2) emissions from the water surface of the Three Gorges Reservoir, currently the largest hydroelectric reservoir in the world, were measured using floating static chambers over the course of a yearlong survey. The results showed that the average annual CO2 flux was (163.3 ± 117.4) mg CO2/(m·hr) at the reservoir surface, which was larger than the CO2 flux in most boreal and temperate reservoirs but lower than that in tropical reservoirs. Significant spatial variations in CO2 flux were observed at four measured sites, with the largest flux measured at Wushan (221.9 mg CO2/(m·hr)) and the smallest flux measured at Zigui (88.6 mg CO2/(m·hr)); these differences were probably related to the average water velocities at different sites. Seasonal variations in CO2 flux were also observed at four sites, starting to increase in January, continuously rising until peaking in the summer (June– August) and gradually decreasing thereafter. Seasonal variations in CO2 flux could reflect seasonal dynamics in pH, water velocity, and temperature. Since the spatial and temporal variations in CO2 flux were significant and dependent on multiple physical, chemical, and hydrological factors, it is suggested that long-term measurements should be made on a large spatial scale to assess the climatic influence of hydropower in China, as well as the rest of the world.
07. Deaths of overwintering Nanorana spp. tadpoles due to desiccation during check dam maintenance in a western Himalayan stream, India

affected by drought, although many amphibians exhibit plasticity in the duration of tadpole development, in response to drought conditions, with trade-offs such as reduced body condition, survival etc. (Cayuela et al., 2016; Yeung, 2021). Droughts may be induced by human activity such as when check dams are drained for maintenance purposes. Check dams are important civil engineering structures built for soil conservation, groundwater recharging and water extraction, and are very common in Indian streams (Agoramoorthy et al., 2008). Here, we report the first observations of the deaths of overwintering tadpoles of two species of Nanorana during check dam maintenance. It is known that check dams have negative impacts on stream channel morphology (Fortugno et al., 2017), water quality, velocity, and substrate fineness (Kang & Kazama, 2012), cause loss of larval microhabitat (Thomas et al., 2019), and influence the breeding ecology of frogs (Lind et al., 1996). However the influence of check dam maintenance has been little documented. Our observations concern two dicroglossid frog species. The small paa frog Nanorana minica (Dubois, 1975) that is associated with montane subtropical forests and streams distributed in Nepal, Uttarakhand and Himachal Pradesh at 1000–2400 m a.s. l. (Ohler et al., 2004; Bhattarai et al., 2020; Frost, 2021). It is listed as Vulnerable on the IUCN Red List and major conservation threats are waterway management and loss of habitat through forest clearance (Ohler et al., 2004). The other species is the Himalaya paa frog Nanorana vicina (Dubois, 1976) that is distributed in the Himalayan front of India, north-central Pakistan from Kashmir, Himachal Pradesh to Punjab, and Uttarakhand ranging from 2000–3000 m a.s. l. and is associated with montane streams, springs, fountains and other running water within open forest and grassland habitats (Ohler & Dutta, 2004; Frost 2021). Apart from morphological descriptions and other natural history records, little is known of the larval ecology of either species (Das & Dutta, 2007; Sircar, 2010; Banerjee et al., 2020; Gill et al., 2020; Jithin, 2021). Jithin (2021) reported overwintering tadpoles of N. minica and N. vicina from the western Himalaya, India. The overwintering tadpoles feed on periphyton growing on check dam walls, bedrocks, boulders, cobbles, leaf litter surface, submerged logs in the pool; humus and animal carcasses; the check dam pools also offer a temperature gradient (Boix-Fayos et al., 2007: Banerjee et al., 2020; Jithin, 2021). We recorded tadpole mortality at two check dam maintenance events along the Dhobhighat (Ringali Gad) stream, flowing through the Mussoorie Wildlife Sanctuary. This second-order stream flows through private resorts,
Negative-bias-temperature-instability and hot carrier effects in nanowire junctionless p-channel multigate transistors

Negative-bias-temperature-instability (NBTI) and hot-carrier induced device degradation have been experimentally compared between accumulation mode (AM) p-channel multigate transistors (pMuGFETs) and junctionless (JL) pMuGFET. NBTI degradation is less significant in junctionless pMuGFETs than AM pMuGFETs. The threshold voltage shift is less significant in junctionless transistors than AM transistors. The device simulation shows that the peak of lateral electric field and the impact ionization rate of AM device are larger than those of junctionless devices.
Application of Percutaneous Needle Electrolysis Does Not Elicit Temperature Changes: An In Vitro Cadaveric Study

Percutaneous needle electrolysis (PNE) consists of the ultrasound-guided application of a galvanic electrical current through a solid filament needle. One proposed therapeutic mechanism for this intervention is a potential thermal effect. The aim of this study was to investigate if the application of PNE induces changes in temperature in different cadaveric musculoskeletal tissues. A repeated measure experimental cadaveric study was designed with 10 cryopreserved knees (5 men, 5 women). Sterile stainless-steel needles of 40 mm length and 0.30 mm caliber were used in this study. An ultrasound-guided needling puncture was performed in the targeted tissue (patellar tendon, infra-patellar fat, and vastus medialis muscle). Additionally, the tip of the needle was placed next to the thermometer sensor at the minimum possible distance without direct contact with it. The temperature differences before and after different applications were measured. The applications were: three applications for 3 s of 3 mA of intensity (3:3:3) when the tendon was the targeted tissue, three applications for 3 s of 1.5 mA of intensity (1.5:3:3) when the fat or muscle was the targeted tissue, and 24 s of 1 mA of intensity (1:24:1) in all tissues. No statistically significant Group*Time interactions were found in any tissue (tendon: F = 0.571, p = 0.459, ŋ2 = 0.03; fat pad: F = 0.093; p = 0.764, ŋ2 = 0.01; muscle: F = 0.681; p = 0.420, ŋ2 = 0.04). Overall, no changes in temperature were observed between both applications in the tendon (3:3:3 vs. 1:24:1) and fat/muscle (1.5:3:3 vs. 1:24:1) tissues. The application of two different percutaneous needle electrolysis protocols did not produce appreciable thermal changes in the tendon, fat, and muscle tissues of human cadavers. The results from the current cadaver study support that a thermal effect should not be considered as a mechanism of clinical action regardless of the targeted human tissue when applying percutaneous needle electrolysis since no changes in temperature after its application were observed.