Miracle-dz/UniFAR-FTUs huggingface dataset:
Utilizando NFV para Implementar a Difusão Confiável e Ordenada de Mensagens na Rede

Este trabalho apresenta um backbone virtual baseado em NFV (Network Function Virtualization) que oferece servicos de difusao de mensagens implementados na propria rede. Os servicos de difusao sao frequentemente utilizados para a construcao de aplicacoes distribuidas tolerantes a falhas. Esta solucao oferece uma primitiva de difusao confiavel e tres primitivas de difusao ordenada de mensagens: FIFO (First-In First-Out), Causal e Atomica. A difusao confiavel garante a entrega das mensagens transmitidas em uma rede SDN (Software-Defined Network) por todos os processos corretos. As estrategias de difusao ordenada garantem que as mensagens sao entregues todas na mesma ordem (atomica), de acordo com a ordem em que foram enviadas pela origem (FIFO) ou obedecendo a ordem causal. O backbone virtual garante a ordem das mensagens atraves de um sequenciador, tambem implementado como uma VNF, denominada de VNF-Sequencer. A estrategia proposta foi implementada e resultados experimentais sao apresentados.
The Glaucoma Patient

A 62-year-old male presents to the ophthalmology service following a referral from his optometrist regarding dilated fundus exam abnormalities. The patient denies ocular symptoms and feels that his vision is normal. His past medical history is significant for type 2 diabetes mellitus, coronary artery disease, alcoholic liver disease, and no past ocular history. On exam, his best corrected visual acuity is 20/25 bilaterally. His intraocular pressure (IOP) is 16mmHg in the right eye and 12 mmHg in the left eye. He states that his pressures are “always around there” during visits to his optometrist’s office. His pupils are equal, round, and reactive to light and accommodation. Anterior segment examination is normal and the patient is phakic. On gonioscopy, there are open angles in both eyes and no synechiae or abnormal pigmentation. Dilated fundus exam shows a cup-to-disc ratio of 0.75 in both eyes and a right eye disc hemorrhage inferotemporally. There is peripapillary atrophy and inferoretinal neuroretinal rim
Printed cisplatin on microneedle arrays for transdermal delivery enhances olaparib-induced synthetic lethality in a mouse model of homologous recombination deficiency

Small molecule inhibitors targeting specific proteins are claiming a continuously growing share in cancer therapy, more commonly in combination with traditional chemotherapeutic drugs. While these inhibitors are taken orally, the majority of chemotherapies are administered through intravenous injection in the hospital premises. Alternative routes for chemotherapy administration would allow more frequent administration at lower dosing by the patient oneself, allowing combination treatment with reduced side effects. Here, we employed laser printing to prepare microneedles for transdermal delivery of cisplatin. Combination treatment with cisplatin transdermally and the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib orally leads to effective treatment in a cancer xenograft mouse model in vivo, while reducing the risk for systemic side effects. This work opens new avenues in anti-cancer therapy by allowing the administration of chemotherapy without the need for intravenous injection alone or in combination with other therapies.
Polarização elíptica: influência no desempenho de cobertura daTV digital

O cenario tecnologico na area de transmissao empregando tecnologia analogica estava bem segmentado e nao oferecia um ambiente de grande interesse em pesquisas especificas para desenvolvimentos de temas relacionados a antena de transmissao para televisao aberta. Com a implantacao do sistema de transmissao empregando a tecnologia digital, que agrega como principal novidade a possibilidade de mobilidade e portabilidade do sistema de recepcao , o interesse nos estudos e pesquisas retomou, apresentando como um dos principais temas a serem desenvolvidos a utilizacao de polarizacao circular ou eliptica comparada com a polarizacao horizontal, que era a mais utilizada pela emissoras. Tendo em vista este novo cenario e a necessidade de avaliacao por meio de uma metodologia cientifica do comportamento do sistema irradiante de transmissao no resultado no desempenho da estacao transmissora, foram estabelecidas as metas que definem o escopo para este trabalho: analisar a influencia do tipo de sistema irradiante em funcao da area de cobertura desejada e das possibilidades de recepcao fixa interna, fixa externa, portatil e movel, frente as diversidades especificas do ambiente de propagacao da regiao estudada devido as condicoes topograficas e ambientais. Os criterios a serem empregados serao os teoricos de predicao de propagacao e pratico de levantamento de campo dos sinais recebidos os quais irao fornecer dados para a analise das variaveis que influenciam no comportamento do sistema de transmissao, considerando o local e as caracteristicas tecnicas de instalacao da estacao de transmissao principal e variando a polarizacao do sistema irradiante nas configuracoes horizontal, vertical e eliptica.
Atlas of the Medieval World

In this atlas, pictures of art and architecture accompanying an expertly written text are featured alongside stunning maps covering nearly a millennium of medieval civilizations around the world, capturing the Arab invasions of Europe, the empire of Charlemagne, the African kingdoms of Songhai and Mali, the Crusades, the Viking and Mongol invasions
Resting-state networks representation of the global phenomena

Resting-state functional magnetic resonance imaging (rsfMRI) has been widely applied to investigate spontaneous neural activity, often based on its macroscopic organization that is termed resting-state networks (RSNs). Although the neurophysiological mechanisms underlying the RSN organization remain largely unknown, accumulating evidence points to a substantial contribution from the global signals to their structured synchronization. This study further explored the phenomenon by taking advantage of the inter- and intra-subject variations of the time delay and correlation coefficient of the signal timeseries in each region using the global mean signal as the reference signal. Consistent with the hypothesis based on the empirical and theoretical findings, the time lag and correlation, which have consistently been proven to represent local hemodynamic status, were shown to organize networks equivalent to RSNs. The results not only provide further evidence that the local hemodynamic status could be the direct source of the RSNs’ spatial patterns but also explain how the regional variations in the hemodynamics, combined with the changes in the global events’ power spectrum, lead to the observations. While the findings pose challenges to interpretations of rsfMRI studies, they further support the view that rsfMRI can offer detailed information related to global neurophysiological phenomena as well as local hemodynamics that would have great potential as biomarkers.
Research on the biological mechanism and potential application of CEMIP

Cell migration–inducing protein (CEMIP), also known as KIAA1199 and hyaluronan-binding protein involved in hyaluronan depolymerization, is a new member of the hyaluronidase family that degrades hyaluronic acid (HA) and remodels the extracellular matrix. In recent years, some studies have reported that CEMIP can promote the proliferation, invasion, and adhesion of various tumor cells and can play an important role in bacterial infection and arthritis. This review focuses on the pathological mechanism of CEMIP in a variety of diseases and expounds the function of CEMIP from the aspects of inhibiting cell apoptosis, promoting HA degradation, inducing inflammatory responses and related phosphorylation, adjusting cellular microenvironment, and regulating tissue fibrosis. The diagnosis and treatment strategies targeting CEMIP are also summarized. The various functions of CEMIP show its great potential application value.
Effect of the metal nature on the I-V characteristics of CdTe diodes for ionizing radiation detectors

The electrical characteristics of CdTe-based surface barrier structures, which can be used as spectroscopic X/γ-ray detectors, have been investigated. The metal-semiconductor structures were obtained by thermal (resistive) vacuum deposition of various metals onto detector-grade CdTe crystals. Metals with different work functions, such as Al, In, Ni, Ti, Cr, and Au, were employed as electrode materials for rectifying contacts. An ohmic contact was created on the entire opposite surface of the crystals by chemical deposition of Au from a gold chloride solution. The surface processing of CdTe crystals before the formation of both rectifying and ohmic contacts included mechanical and chemical polishing, as well as Ar-ion bombardment. Dark currents at reverse voltage of 1500 V did not exceed 4 nA for all the diodes except for the Au/CdTe/Au structure. The effect of the metal nature on the I-V characteristics and charge carrier transport mechanisms was studied, and the features of voltage dependences of dark current were explained by differences in the work functions of the metals, as well as the contact deposition technique.
Spatial statistics in environmental science

A miniature microphone for a head-mounted midget hearing aid wherein the diaphragm divides the microphone housing into two separate chambers, the housing having a forward portion with a sound admitting aperture therein which is substantially non-restrictive to passage of sound waves therethrough so that the sound waves may freely enter one of the chambers within the housing; the microphone housing also having a wall portion at the rear of the microphone, said wall portion having a plurality of minute apertures therethrough and defining a transmission time delaying acoustic resistance admitting sound pressure variations into the other chamber of the housing.
Information sources in social sciences

The author gives an overview on different kinds of information resources with the emphasis on the situation in developing countries. The state of libraries, documentation centres, data archives, and non-formal resources as well as the information and communication technology is discussed. The information source infrastructure in social sciences needs to be strengthened. It is essential for social sciences in developing countries to pay much greater attention to the parochial nature of its knowledge and the need for indigenisation. The author presents some proposals for a strategy to be evolved by the social scientists and informaiton professionals in developing countries. In a situation of increasing demand and decreasing resources cooperation resp. networking is the only alternative
HMGB1: a double-edged sword and therapeutic target in the female reproductive system

HMGB1 that belongs to the High Mobility Group-box superfamily, is a nonhistone chromatin associated transcription factor. It is present in the nucleus of eukaryotes and can be actively secreted or passively released by kinds of cells. HMGB1 is important for maintaining DNA structure by binding to DNA and histones, protecting it from damage. It also regulates the interaction between histones and DNA, affecting chromatin packaging, and can influence gene expression by promoting nucleosome sliding. And as a DAMP, HMGB1 binding to RAGE and TLRs activates NF-κB, which triggers the expression of downstream genes like IL-18, IL-1β, and TNF-α. HMGB1 is known to be involved in numerous physiological and pathological processes. Recent studies have demonstrated the significance of HMGB1 as DAMPs in the female reproductive system. These findings have shed light on the potential role of HMGB1 in the pathogenesis of diseases in female reproductive system and the possibilities of HMGB1-targeted therapies for treating them. Such therapies can help reduce inflammation and metabolic dysfunction and alleviate the symptoms of reproductive system diseases. Overall, the identification of HMGB1 as a key player in disease of the female reproductive system represents a significant breakthrough in our understanding of these conditions and presents exciting opportunities for the development of novel therapies.
The Effects of a Biomimetic Hybrid Meso- and Nano-Scale Surface Topography on Blood and Protein Recruitment in a Computational Fluid Dynamics Implant Model

The mechanisms underlying bone-implant integration, or osseointegration, are still incompletely understood, in particular how blood and proteins are recruited to implant surfaces. The objective of this study was to visualize and quantify the flow of blood and the model protein fibrinogen using a computational fluid dynamics (CFD) implant model. Implants with screws were designed with three different surface topographies: (1) amorphous, (2) nano-trabecular, and (3) hybrid meso-spikes and nano-trabeculae. The implant with nano-topography recruited more blood and fibrinogen to the implant interface than the amorphous implant. Implants with hybrid topography further increased recruitment, with particularly efficient recruitment from the thread area to the interface. Blood movement significantly slowed at the implant interface compared with the thread area for all implants. The blood velocity at the interface was 3- and 4-fold lower for the hybrid topography compared with the nano-topography and amorphous surfaces, respectively. Thus, this study for the first time provides insights into how different implant surfaces regulate blood dynamics and the potential advantages of surface texturization in blood and protein recruitment and retention. In particular, co-texturization with a hybrid meso- and nano-topography created the most favorable microenvironment. The established CFD model is simple, low-cost, and expected to be useful for a wide range of studies designing and optimizing implants at the macro and micro levels.
Novel Canthin-6-one Derivatives: Design, Synthesis, and Their Antiproliferative Activities via Inducing Apoptosis, Deoxyribonucleic Acid Damage, and Ferroptosis

A series of novel canthin-6-one (CO) derivatives (8a–l) were designed and synthesized by introducing different amide side chains at the C-2 position, and their water solubility, antiproliferative activity, and preliminary mechanism were investigated. Most compounds displayed high cytotoxicity exhibiting low-micromolar IC50 values against four human cancer cell lines, especially HT29 cells. Meanwhile, the water solubility of active CO derivatives was significantly improved. Among these compounds, compound 8h with the N-methyl piperazine group exhibiting the highest antiproliferative capability with an IC50 value of 1.0 μM against HT29 cells, which was 8.6-fold lower than that of CO. Furthermore, 8h could upregulate the levels of reactive oxygen species, leading to mitochondrial damage. In addition, 8h could promote cell apoptosis and DNA damage by regulating the expression of apoptosis-associated proteins (Bcl-2 and cleaved-caspase 3) and the DNA damage-associated protein (H2AX). Most importantly, 8h also exerted ferroptosis by reducing the GSH level and GPX4 expression as well as increasing the lipid peroxidation level. Thus, the novel CO derivative 8h with N-methylpiperazine represents a promising anticancer candidate and warrants a more intensive study.
SLEEP-RELATED PROBLEMS IN CHILDREN WITH CEREBRAL PALSY AND ITS CORRELATION WITH SLEEP DISTURBANCE IN PRIMARY CAREGIVERS

Background: Sleep-related issues can present additional challenges for children with cerebral palsy (CP). This study investigated sleep problems in children with CP and their correlation with primary caregivers attending a tertiary care centre. Materials and Methods: This is a cross-sectional observational study conducted at Paediatric OPD, Neurology OPD and DEIC OPD of Govt. RMH, Thanjavur, Tamil Nadu, India from Jan 2019 to Dec 2019. Children aged 6-15 years with CP and their primary caregivers were included. A validated sleep questionnaire was used to assess sleep-related problems. Data were analyzed using descriptive statistics and chi-square tests. Results: The study included 70 children with CP (55.72% male) and their caregivers. Most children had spastic quadriplegia (40%) and a history of seizures (74.28%). Sleep disturbances were prevalent among both children and caregivers. Disorders of initiating and maintaining sleep (DIMS) had a prevalence of 31.43%, followed by sleep breathing disorders (SBD) at 21.43%. Sleep-wake transition disorders (SWTD) were observed in 10% of the participants. Significant associations were found between sleep disturbance in children and their caregivers, particularly for DIMS, SBD, and sleep hyperhidrosis (SHY) scores. Conclusion: Sleep disturbances are common in children with cerebral palsy and have an impact on their caregivers. This study highlights the interconnectedness of sleep disruption between children with CP and their caregivers. Understanding and addressing sleep-related issues in this population can improve the overall well-being and quality of life for children and their caregivers. Further research and interventions are needed to manage sleep problems in children with cerebral palsy effectively
PSO-Incorporated Hybrid Artificial Hummingbird Algorithm with Elite Opposition-Based Learning and Cauchy Mutation: A Case Study of Shape Optimization for CSGC–Ball Curves

With the rapid development of the geometric modeling industry and computer technology, the design and shape optimization of complex curve shapes have now become a very important research topic in CAGD. In this paper, the Hybrid Artificial Hummingbird Algorithm (HAHA) is used to optimize complex composite shape-adjustable generalized cubic Ball (CSGC–Ball, for short) curves. Firstly, the Artificial Hummingbird algorithm (AHA), as a newly proposed meta-heuristic algorithm, has the advantages of simple structure and easy implementation and can quickly find the global optimal solution. However, there are still limitations, such as low convergence accuracy and the tendency to fall into local optimization. Therefore, this paper proposes the HAHA based on the original AHA, combined with the elite opposition-based learning strategy, PSO, and Cauchy mutation, to increase the population diversity of the original algorithm, avoid falling into local optimization, and thus improve the accuracy and rate of convergence of the original AHA. Twenty-five benchmark test functions and the CEC 2022 test suite are used to evaluate the overall performance of HAHA, and the experimental results are statistically analyzed using Friedman and Wilkerson rank sum tests. The experimental results show that, compared with other advanced algorithms, HAHA has good competitiveness and practicality. Secondly, in order to better realize the modeling of complex curves in engineering, the CSGC–Ball curves with global and local shape parameters are constructed based on SGC–Ball basis functions. By changing the shape parameters, the whole or local shape of the curves can be adjusted more flexibly. Finally, in order to make the constructed curve have a more ideal shape, the CSGC–Ball curve-shape optimization model is established based on the minimum curve energy value, and the proposed HAHA is used to solve the established shape optimization model. Two representative numerical examples comprehensively verify the effectiveness and superiority of HAHA in solving CSGC–Ball curve-shape optimization problems.
SUPERVIVENCIA DAS EMPRESAS INNOVADORAS ESPAÑOLAS: EFECTOS DA INNOVACIÓN

This paper analyzes the determinants of business failure through a binomial logistic model for a sample of 223 Spanish innovative companies and the year 2006. The results show that profitability, guarantees, efficiency and age of firms negatively influence the probability of failure. Innovation also exerts an indirect effect on the probability of bankruptcy through profitabi- lity.
Protocol for establishing a model for integrated influenza surveillance in Tamil Nadu, India

The potential for influenza viruses to cause public health emergencies is great. The World Health Organisation (WHO) in 2005 concluded that the world was unprepared to respond to an influenza pandemic. Available surveillance guidelines for pandemic influenza lack the specificity that would enable many countries to establish operational surveillance plans. A well-designed epidemiological and virological surveillance is required to strengthen a country’s capacity for seasonal, novel, and pandemic influenza detection and prevention. Here, we describe the protocol to establish a novel mechanism for influenza and SARS-CoV-2 surveillance in the four identified districts of Tamil Nadu, India. This project will be carried out as an implementation research. Each district will identify one medical college and two primary health centres (PHCs) as sentinel sites for collecting severe acute respiratory infections (SARI) and influenza like illness (ILI) related information, respectively. For virological testing, 15 ILI and 10 SARI cases will be sampled and tested for influenza A, influenza B, and SARS-CoV-2 every week. Situation analysis using the WHO situation analysis tool will be done to identify the gaps and needs in the existing surveillance systems. Training for staff involved in disease surveillance will be given periodically. To enhance the reporting of ILI/SARI for sentinel surveillance, trained project staff will collect information from all ILI/SARI patients attending the sentinel sites using pre-tested tools. Using time, place, and person analysis, alerts for abnormal increases in cases will be generated and communicated to health authorities to initiate response activities. Advanced epidemiological analysis will be used to model influenza trends over time. Integrating virological and epidemiological surveillance data with advanced analysis and timely communication can enhance local preparedness for public health emergencies. Good quality surveillance data will facilitate an understanding outbreak severity and disease seasonality. Real-time data will help provide early warning signals for prevention and control of influenza and COVID-19 outbreaks. The implementation strategies found to be effective in this project can be scaled up to other parts of the country for replication and integration.
DOA Estimation of Coherent Signals Based on EPUMA Method With Frequency Beam Scanning Leaky-Wave Antennas

A technique to estimate the DOAs of coherent sources using a passive frequency beam scanning leaky-wave antenna (FBS-LWA) with a subspace based method is presented. To do so, a combination of enhanced principal-singular-vector utilization for modal analysis (EPUMA) algorithm and linear interpolation technique is proposed. The simulation results show the effectiveness of the proposed method for DOA estimation of multiple coherent signals with hyper-resolution capabilities. With respect to classical antenna arrays, such FBS-LWAs reduce system complexity since only one radio-frequency receiver is required to perform DOA estimation in one angular plane.
Glaciological Investigations in the Crête Area, Central Greenland: A Search for a new Deep-Drilling Site

The results of the 1984-85 post-GISP campaigns in central Greenland are presented. Eight ice cores were obtained, some spanning up to 360 years. We present: I. Geographical positions and elevations at the drill sites, II. Density and temperature in the bore holes, III. Filtered δ18O profiles and accumulation-rate variations along the ice cores. The δ18O and accumulation profiles, along with those from the 400 m Crête ice core obtained in 1974, are compared. The accumulation-rate series over a large region have a very high coherence. This indicates that a single bore hole in this region would give a representative accumulation time series over a long period. Further, it appears that for this region there is a linear relation between the measured annual accumulation rate and the mean annual δ18O values. Thus the area between Crête and Summit, just west of the ice divide, seems to be favorable for a deep-drilling operation.