Miracle-dz/UniFAR-FTUs huggingface dataset:
Oropharyngeal Shedding of Gammaherpesvirus DNA by Cats, and Natural Infection of Salivary Epithelium

Felis catus gammaherpesvirus-1 (FcaGHV1), a novel candidate oncogenic virus, infects cats worldwide. Whether the oropharynx is a site of virus shedding and persistence, and whether oronasal carcinomas harbor FcaGHV1 nucleic acid were investigated. In a prospective molecular epidemiological study, FcaGHV1 DNA was detected by cPCR in oropharyngeal swabs from 26/155 (16.8%) of cats. Oropharyngeal shedding was less frequently detected in kittens ≤3 months of age (5/94, 5.3%) than in older animals; >3 months to ≤1 year: 8/26, 30.8%, (p = 0.001, OR 7.91, 95% CI (2.320, 26.979)); >1 year to ≤6 years: 10/20, 50%, (p < 0.001, OR 17.8 95% CI (5.065, 62.557)); >6 years: 3/15, 33% (p = 0.078). Provenance (shelter-owned/privately owned) was not associated with shedding. In situ hybridization (ISH) identified FcaGHV1-infected cells in salivary glandular epithelium but not in other oronasal tissues from two of three cats shedding viral DNA in the oropharynx. In a retrospective dataset of 11 oronasopharyngeal carcinomas, a single tumor tested positive for FcaGHV1 DNA by ISH, a papillary carcinoma, where scattered neoplastic cells showed discrete nuclear hybridization. These data support the oronasopharynx as a site of FcaGHV1 shedding, particularly after maternal antibodies are expected to decline. The salivary epithelium is identified as a potential site of FcaGHV1 persistence. No evidence supporting a role for FcaGHV1 in feline oronasal carcinomas was found in the examined tumours.
A Serious Game to Promote and Facilitate Entrepreneurship Education for Young Students

The paper describes a serious gamedesigned and implemented within the framework of the European project “Posso … Non Posso … Vado! PNPV Project Rev.2 (I can . I cannot . I go! ) which aims to introduce and foster an entrepreneurial mindset among young people. The focus of the game is on the management of a touristic company, in a complex market in which players compete with other companies/players. After a brief overview on Entrepreneurship Education, the paper describes the structure of the gamethat allows players to face increasingly complex situations, through learning by doing and learning by failing methodologies. Thenthetools integrated in the game to support teachersin analyzing students’ activities are described.
Issues in Statewide Scale up of a Multi-Tiered System of Support

Tiered instructional supports are on a steep growth trajectory in the US and getting underway internationally as a means to providing equitable education to all student groups. In the US, the Department of Education funded the expansion of multi-tiered system of support (MTSS) through school and personnel improvement grants to states. This retrospective article examines the history of MTSS and California’s significant investment to scale up the practice statewide, with an eye to identifying key issues that are likely to surface in other such ambitious state efforts. We examine the infrastructure support methodology to develop local capacity to support school-level implementation with measured fidelity. We present some preliminary results from a small sample comparison study that demonstrate students’ academic achievement increased when the California MTSS efforts resulted in implementation with adequate fidelity. These findings suggest long-term replication of this initiative will mirror other student-level impact studies showing positive gains on measures of academic progress, in this case, English Language Arts and Math.
Determination of the genetic diversity in populations of halophytic grass S. ioclados using PBA markers

The genetic structure of salt-tolerant halophytic grass Sporobolus ioclados collected from inland and coastal areas of Pakistan was determined using P450 based analog (PBA); the functional genomic markers. Our data revealed high polymorphism (96%) in the collected germplasm. The high genetic variability could be attributed to outcrossing, and sexual reproduction. An analysis of molecular variance depicted higher genetic diversity (80%) within the populations and lower (20%) among the populations. The low genetic diversity among the inland and coastal populations might be due to fragmentation and long physical distances. The dendrogram and principal component analysis clearly distinguished the genotypes of the two populations into two distinct clusters. Our data demonstrated that PBA markers are reliable and reproducible for assessing genetic diversity in halophytic grass and provides valuable insight for future breeding and conservation programs.
Characterization Summary of Performance, Reliability, and Threshold Voltage Distribution of 3D Charge-Trap NAND Flash Memory

Solid-state drive (SSD) gradually dominates in the high-performance storage scenarios. Three-dimension (3D) NAND flash memory owning high-storage capacity is becoming a mainstream storage component of SSD. However, the interferences of the new 3D charge-trap (CT) NAND flash are getting unprecedentedly complicated, yielding to many problems regarding reliability and performance. Alleviating these problems needs to understand the characteristics of 3D CT NAND flash memory deeply. To facilitate such understanding, in this article, we delve into characterizing the performance, reliability, and threshold voltage (Vth) distribution of 3D CT NAND flash memory. We make a summary of these characteristics with multiple interferences and variations and give several new insights and a characterization methodology. Especially, we characterize the skewed (Vth) distribution, (Vth) shift laws, and the exclusive layer variation in 3D NAND flash memory. The characterization is the backbone of designing more reliable and efficient flash-based storage solutions.
Vav1 Promotes B-Cell Lymphoma Development

Vav1 is normally and exclusively expressed in the hematopoietic system where it functions as a specific GDP/GTP nucleotide exchange factor (GEF), firmly regulated by tyrosine phosphorylation. Mutations and overexpression of Vav1 in hematopoietic malignancies, and in human cancers of various histologic origins, are well documented. To reveal whether overexpression of Vav1 in different tissues suffices for promoting the development of malignant lesions, we expressed Vav1 in transgenic mice by using the ubiquitous ROSA26 promoter (Rosa Vav1). We detected Vav1 expression in epithelial tissues of various organs including pancreas, liver, and lung. While carcinomas did not develop in these organs, surprisingly, we noticed the development of B-cell lymphomas. Rac1-GTP levels did not change in tissues from Rosa Vav1 mice expressing the transgenic Vav1, while ERK phosphorylation increased in the lymphomas, suggesting that signaling pathways are evoked. One of the growth factors analyzed by us as a suspect candidate to mediate paracrine stimulation in the lymphocytes was CSF-1, which was highly expressed in the epithelial compartment of Rosa Vav1 mice. The expression of its specific receptor, CSF-1R, was found to be highly expressed in the B-cell lymphomas. Taken together, our results suggest a potential cross-talk between epithelial cells expressing Vav1, that secrete CSF-1, and the lymphocytes that express CSF-1R, thus leading to the generation of B-cell lymphomas. Our findings provide a novel mechanism by which Vav1 contributes to tumor propagation.
Examining the Associations between Adverse Childhood Experiences, Health Risk Behaviours, and Psychological Well-Being in a Convenience Sample of Lithuanian University Students

This study examines the associations between adverse childhood experiences (ACEs), health risk behaviours, and psychological well-being among Lithuanian university students. A cross-sectional survey was carried out with a convenience sample of 393 students (80.7% females and 19.3% males) recruited from mostly undergraduate courses (96.4%) in Lithuanian universities. Participants, aged 18–25 years (21.07 ± 1.53), completed a web-based survey in which they were asked to retrospectively self-report on ACEs while answering questions on health risk behaviours (e.g., smoking, substance use, riding a car with a drunk driver) and psychological well-being. Only 8.7% of the study sample experienced no ACEs, and almost half of the sample (48.9%) experienced ≥4 ACEs. Findings from adjusted models showed that, compared with students with no ACEs, those who experienced ≥4 ACEs had higher odds of lifetime illicit drug use (AOR = 2.73, p < 0.05), riding with a drunk driver (AOR = 2.44, p < 0.05), suicidal ideation before age 18 (AOR = 28.49, p < 0.01) and in the past 12 months (AOR = 5.39, p < 0.01). An increased number of ACEs was also associated with lower psychological well-being (B = −3.94, p < 0.001). Findings from this study have implications for mental health professionals as well as university administrators, as students with a higher number of traumatic experiences may require greater levels of support and services.
Protective activity of phalaris canariensis against methotrexate-induced nephrotoxicity via BCL2 pathway

This study aimed to evaluate the protective effects of the ethanolic extract obtained from the seeds of phalaris canariensis, against nephro-toxicity induced by methotrexate (MTX). Toxicity was induced by a single dose of MTX (20 mg/kg) and ethanolic extract administered in three different doses (100, 200 and 400 mg/kg) daily for 15 days. Urea and creatinine were measured in serum. In addition, malondialdehyde (MDA) and total nitrites, were measured in kidney tissues. At the same time, expression of kidney injury molecule-1 (KIM-1) and expression of BCL2 in kidney were measured. The ethanolic extract showed dose-dependent reduction in urea, creatinine, renal MDA, renal total nitrites and expression of KIM-1, which were increased with MTX administration, however, the extract dose-dependently, increased BCL2 expression that was reduced with MTX administration. in conclusion, this study suggests that the seed extracts from P. canariensis exhibit protective potentials against MTX-induced nephro-toxicity and can be considered a potential therapeutic agent in prevention of MTX-induced toxicity.
Application of deep learning and classical machine learning methods in the diagnosis of attention deficit hyperactivity disorder according to temperament features

Attention deficit hyperactivity disorder (ADHD) is a common childhood neurodevelopmental disorder with symptoms of attention deficit, hyperactivity and impulsivity, with a prevalence of 8%–12% worldwide. Various studies have revealed that there may be a relationship between ADHD and temperament traits in the etiology of ADHD, which has a multifactorial etiology. According to our knowledge, there is no study in the literature that determines the use of machine learning methods in diagnosing ADHD uses a data set created with temperament characteristics. Different methods were used in this first study. The study included 60 ADHD patients and 60 control group children. The test scores of these children were collected from the Department of Child and Adolescent Psychiatry, Kahramanmaraş Sütçü İmam University Medical Faculty, after obtaining the necessary ethics committee permission. ADHD diagnosis was made according to DSM‐5 classification. According to temperament characteristics, the highest classification success in ADHD diagnosis was calculated as 92.5% in decision tree method. Long short term memory (LSTM), one of the deep learning methods, achieved 88% classification success. The success of both methods is quite high and they have been compared with some ADHD classification studies in the literature.
Detection of Generative Linguistic Steganography Based on Explicit and Latent Text Word Relation Mining Using Deep Learning

Covert communication channels can be easily constructed using text steganography based on social media. Offenders can easily utilize these channels to engage in various criminal activities, which brings great challenges in maintaining the security of cyberspace. Among the text information hiding methods, generative linguistic steganography poses the biggest threat to network security because it does not need the original carrier and has high embedding efficiency. The existing generative linguistic steganalysis methods fail to deeply mine text word relation, hence the detection performance is relatively unsatisfactory. In this article, we prove that there is explicit and latent steganography-sensitive text word relation. Based on this, we propose a generative linguistic steganalysis method based on Explicit and Latent text word relation Mining, named ELM. First, we employ a distributed readin module to convert words into real number vectors. Then, MRA (Mining Relation by Attentions) is proposed to mine the explicit and latent text word relation. Finally, global adaptive classification module is presented to exploit the mined relation feature to predict whether secret information is embedded in the current text segment. Experimental results demonstrate that the detection performance of ELM is better than the existing generative linguistic steganalysis methods.
Therapeutic Efficacy and Tolerability of 30% Versus 70% Concentrations of Topical Trichloroacetic Acid in Patients with Xanthelasma Palpebrarum: A Randomized Clinical Trial

Background: Xanthelasma palpebrarum (XP) is the most common cutaneous xanthoma. It is a benign lesion that appears as yellowish plaque near the inner canthus of the eyelid. There is still paucity of strong evidence for the single best effective treatment of XP. Objective: The aim of this study was to assess the clinical efficacy and tolerability of once application of two concentrations of topical trichloroacetic acid (TCA) (30% versus 70%) in treatment of patients with XP. Methods: This randomized clinical trial was conducted on patients presenting to Occuloplastic Clinic at Tanta University Eye Hospital. Patients with Soft and semisolid xanthelasma lesion at upper or lower eyelids were included. Forty patients were randomly distributed into 2 groups: Group 1 treated by once application of 30% TCA and Group 2 treated by once application of 70% TCA. Results: There was a statistically significant (p<0.001) improvement in group 2 compared to group 1. Excellent results where the skin of the lesion returned normal as the rest of the surrounding skin were significantly higher in group 2 (94.1%) than group 1 (14.7%). Group 2 showed absence of significant (p>0.05) association between the clinical outcome and the number, type, or size of the lesion. There was a statistically significant (p<0.001) increase in lid erythema in group 2 compared to group 1 (45.0% versus 0.0%, respectively). Conclusion: A single session peeling with TCA 70% was highly effective than TCA 30% in the treatment of xanthelasma palpebrarum patients whatever the number, type, or size of lesion. The only significantly reported side effect was lid erythema.
Accuracy Assessment, Comparative Performance, and Enhancement of Public Domain Digital Elevation Models (ASTER 30 m, SRTM 30 m, CARTOSAT 30 m, SRTM 90 m, MERIT 90 m, and TanDEM-X 90 m) Using DGPS

Publicly available Digital Elevation Models (DEM) derived from various space-based platforms (Satellite/Space Shuttle Endeavour) have had a tremendous impact on the quantification of landscape characteristics, and the related processes and products. The accuracy of elevation data from six major public domain satellite-derived Digital Elevation Models (a 30 m grid size—ASTER GDEM version 3 (Ast30), SRTM version 3 (Srt30), CartoDEM version V3R1 (Crt30)—and 90 m grid size—SRTM version 4.1 (Srt90), MERIT (MRT90), and TanDEM-X (TDX90)), as well as the improvement in accuracy achieved by applying a correction (linear fit) using Differential Global Positioning System (DGPS) estimates at Ground Control Points (GCPs) is examined in detail. The study area is a hard rock terrain that overall is flat-like with undulating and uneven surfaces (IIT (ISM) Campus and its environs) where the statistical analysis (corrected and uncorrected DEMs), correlation statistics and statistical tests (for elevation and slope), the impact of resampling methods, and the optimum number of GCPs for reduction of error in order to use it in further applications have been presented in detail. As the application of DGPS data at GCPs helps in the substantial reduction of bias by the removal of systematic error, it is recommended that DEMs may be corrected using DGPS before being used in any scientific studies.
Where do capabilities reside? Analysis of related technological diversification in multi-locational firms

ABSTRACT Where do businesses source the capabilities that influence their diversification? From the resource-based perspective, capabilities are located within the firm. For many economic geographers, capabilities are place-based and flow between firms in local areas. Others claim the capabilities that count emerge from non-local collaboration. The value added of this paper is a firm–establishment–patent dataset that helps identify the sources of capabilities regulating technological diversification in the establishments of multi-locational firms. Results show that capabilities located within establishments themselves are most important to the process of diversification, followed by firm capabilities and then place-based capabilities.
THE DIRECT COSTS BURDEN OF BEVACIZUMAB IN SOUTH-WEST ROMANIA

As costs for cancer treatment increase with the reimbursement of new treatments and increasing of patients’ number, prevention and prior detection efforts become even more cost-effective and potentially cost saving. The global economic burden of cancer is mostly unknown. Even though bevacizumab is one of the most prescribed and used angiogenesis inhibitors, it is among the most expensive drugs. This study aimed to generate statistical analyses of the total amounts reimbursed by the Romanian National Health Insurance Fund for treating cancer with Avastin in Dolj County, Romania, from January 1, 2020 to March 31, 2021. We aimed to estimate the real-world incremental costs associated with the use of bevacizumab for metastatic breast cancer, advanced non-small cell lung cancer, metastatic cancer of the colon or rectum, ovarian cancer, advanced renal cell cancer, and cervical cancer. From the total of 351 patients treated with bevacizumab, 114 (31.67%) had colon cancer and 69 (19.17%) had rectum cancer. After we investigated the economic burden of bevacizumab, we observed the highest percentage for the malignant tumour of the colon from all the direct costs. We compared the costs of bevacizumab treatment on diseases and months, observing the highest burden for colon cancer in almost all the months. Molecules such as bevacizumab are adding an appreciable cost burden to the public funded Health Care System and more studies that evaluate their cost-effectiveness are needed.
Prognostic Significance of Telomere Length in newly diagnosed Chronic Lymphocytic Leukemia patients: measured By FlowFISH technique

Telomeres are specialized nucleoprotein structures present at the ends of human chromosomes, and are constituted of a tandem of repeats TTAGGG. They play a crucial role in cellular homeostasis by maintaining genome stability and integrity. These telomeric functions cannot be attained unless telomere lengths are maintained at a level that allows telomeres to avoid chromosome end-to-end fusion, DNA cascade signaling, and genomic instability (lange et al., 2010).
An extensive structural model of supply chain quality management and firm performance

Purpose – The purpose of this paper is to explore the concept of supply chain quality management (SCQM) and to propose a research model that considers the impact of SCQM practices on firm performance. Design/methodology/approach – Based on a comprehensive literature review, SCQM most relevant practices were analyzed and selected. These practices were categorized into four dimensions: upstream (supplier assessment, supplier quality management (QM)), downstream sides of a supply chain (customer focus), internal process (product/service design, process management and logistics) and support practices (top management support, human resource management, information and supply chain integration). The measurement instrument of firm performance was also developed, including three aspects: operational performance, customer satisfaction and financial performance. Findings – An innovative conceptual framework that provides a comprehensive picture covering core dimensions of SCQM and various aspects of firm performanc.
Integration of the Target Position Correction Software with the High Endurance Quadcopter for Search and Rescue Mission

An Unmanned Aerial vehicle (UAV), commonly known as drone, is an aircraft without a human pilot aboard. In recent years, some UAVs are deployed for civil applications, such as policing, firefighting, air pollution monitoring, and aerial search and rescue, etc. Unmanned Aerial vehicle generally include fixed-wing and multi-rotor aircrafts. This research had developed a high endurance quadcopter for search and rescue mission. Target position correction software also was developed in this research. This program uses GPS coordinates embedded in the EXIF information of the aerial photos and more accurately calculates the target’s position. The target’s position error is less than ten meters in 75 meters altitude. Keywords: target position correction software, search and rescue, UAV, quadcopter, and GPS.