Miracle-dz/UniFAR-FTUs huggingface dataset:
Changes in comfort perception and direction change performance of badminton shoes with extensive usage time

This study examined whether the shoe usage time influences the comfort perception and direction change performance of badminton shoes. Fifteen university badminton players performed direction change trials with maximum-effort at new and extensively worn shoe conditions. Two professional badminton shoe models (Shoe Y and Shoe L) were selected to examine if both tested shoes would have similar usage time effect on comfort perception and direction change performance. Comfort perception of in-shoe climate, overall fit, medial-lateral stability, overall cushioning, shoe-ground traction, and overall comfort were measured using a 150 mm Visual Analogue Scales, immediately after the direction change trials. After finishing data collection of new shoe condition (day 1), the tested shoes were assigned to the university badminton team players to simulate the extensively worn condition that normally used during badminton training for eight weeks (i.e., 96 hours in total). The identical testing procedure was performed by the same experimenter for the extensively worn shoe condition (day 2). Paired t-tests were performed to investigate if there were any significant differences between new and extensively worn condition in each of the variables. Significance level was set at P < 0.05. No difference in direction change performance between new and extensively worn conditions was determined in each shoe (P > 0.05). Y shoe indicated significant poorer perception of medial-lateral stability, overall fit, and in-shoe climate (P < 0.05) while L shoe indicated significant poorer perception of overall fit and in-shoe climate for the extensively worn shoe condition, compared to the new shoe condition (P < 0.05). Prolonged shoe usage time plays a role in footwear comfort perception, but not in direction change performance. Changing with a new pairs of shoes would be considered to attain better comfort perception for badminton players during practice and competition.
Overview of wearable electronics and smart textiles

Abstract Protection and esthetics are the two common characteristics typically associated with textiles as clothing. Nevertheless, with the quickly altering needs of today’s consumers, a third characteristic is rising – that of “intelligence” – that is being integrated into fabrics to produce interactive or textiles (or i-textiles). The term electronic textiles, or e-textiles, are used to denote the class of fabric structures that integrate electronic elements with textiles and can sense changes in its environment and respond to it. This new class of wearable electronic systems is being designed to meet new and innovative applications in the military, public safety, healthcare, space exploration, sports, and consumer fitness fields. The goal of this paper is to focus on recent advances in the field of Smart Textiles and pay particular attention to the materials and their manufacturing process. Each technique shows advantages and disadvantages and the aim of this study is to improve the overall usability of smart clothing products by reviewing all developments which have been done in this case in order to straighten the path for future investigations and researches in this field.
A Modular Charging Unit for Hybrid Electrical Vehicle Using Photovoltaic System

The power transfers from the source to different loads in industrial and commercial systems have become a hectic design for power system Designer. Different methods have been proposed to reduce the losses in power transfer in various systems. We are using a modular charging unit for HEV using PV. Wireless power transfer technology has taken a new trend towards power transfer. In this paper a Wireless power transfer technology is proposed for hybrid electric vehicle charging unit. The wireless charging is adopted with the technology of replacing the loosely coupled coils with a transformer. The WPT is initiated with input source of energy from Photovoltaic system and its controller is governed by soft computing techniques to get optimized output for optimal charging. Thus determining how much charge is required to charge a electric vehicle according to the load demand. The proposed WPT is monitored for various robust conditions simulating industrial and commercial standard scenarios and the proposed algorithms is checked for optimal values and then initialed to get a better stability and dynamic analysis of the WPT. By seeing the availability of the conventional resources and demand we are using photovoltaic (PV) as the alternative resources. The P&O algorithm is used with the PV.
Pharmacogenetics of clopidogrel and warfarin in the treatment of cardiovascular diseases: an overview of reviews.

Pharmacogenetics (PGx) is the relationship between an individual's genetic variations and the response to pharmacological treatment. We chose to perform an overview of reviews on PGx testing-guided treatment for cardiovascular diseases, based on clinically relevant gene-drug pairs. We conducted a search on Medline, Embase and Cochrane Library, from their inception to 18 June 2020. The most studied gene-drug pairs were clopidogrel and warfarin associated with cytochrome p450 and vitamin K epoxide reductase complex subunit 1 genes (CYP2C19, CYP2C9 and VKORC1), classified as critically low quality. There is a need for more quality primary studies and systematic reviews that assess the risk of bias, with consistent definitions of clinical outcomes to consider the benefits of PGx testing for cardiovascular diseases.
Semi-supervised EEG emotion recognition model based on enhanced graph fusion and GCN

Objective. To take full advantage of both labeled data and unlabeled ones, the Graph Convolutional Network (GCN) was introduced in electroencephalography (EEG) based emotion recognition to achieve feature propagation. However, a single feature cannot represent the emotional state entirely and precisely due to the instability of the EEG signal and the complexity of the emotional state. In addition, the noise existing in the graph may affect the performance greatly. To solve these problems, it was necessary to introduce feature/similarity fusion and noise reduction strategies. Approach. A semi-supervised EEG emotion recognition model combining graph fusion, network enhancement, and feature fusion was proposed. Firstly, different features were extracted from EEG and then compacted by Principal Component Analysis (PCA), respectively. Secondly, a Sample-by-sample Similarity Matrix (SSM) was constructed based on each feature, and similarity network fusion (SNF) was adopted to fuse the graphs corresponding to different SSMs to take advantage of their complementarity. Then, Network Enhancement (NE) was performed on the fused graph to reduce the noise in it. Finally, GCN was performed on the concatenated features and the enhanced fused graph to achieve feature propagation. Main results. Experimental results demonstrated that: (a) When 5.30 % of SEED and 7.20 % of SEED-IV samples were chosen as the labeled samples, respectively, the minimum classification accuracy improvement achieved by the proposed scheme over state-of-the-art schemes were 1.52 % on SEED and 13.14 % on SEED-IV, respectively. (b) When 8.00 % of SEED and 9.60 % of SEED-IV samples were chosen as the labeled samples, respectively, the minimum training time reduction achieved by the proposed scheme over state-of-the-art schemes were 46.75 s and 22.55 s, respectively. (c) Graph fusion, network enhancement, and feature fusion all contributed to the performance enhancement. (d) The key hyperparameters that affect the performance were relatively few and easy to set to obtain outstanding performance. Significance. This paper demonstrated that the combination of graph fusion, network enhancement, and feature fusion help to enhance GCN-based EEG emotion recognition.
Attention modulates the contextual similarity effect in negative priming: evidence from task demand and attentional capture

ABSTRACT Negative priming refers to the delayed response to a probe target that was previously a prime distractor. Memory retrieval has been proposed as one critical mechanism for the manifestation of negative priming. This perspective perpetuates that the contextual similarity between prime and probe trials should modulate memory retrieval, and therefore, affect negative priming. However, evidence for the contextual similarity effect in negative priming is mixed. The present study tested the hypothesis that attended contextual cues are more likely to be encoded into a distractor representation, and thus, are more likely to modulate the negative priming effect. By manipulating whether the contextual cues were relevant to the task demand in Section 1, and by manipulating whether cues had an abrupt or simultaneous onset, and by analysing reaction time (RT) distributions of the data in Section 2, our results demonstrated that attended cues produced the contextual similarity effect in negative priming, especially when RTs were long.
A novel tissue-mimicking phantom for US/CT/MR-guided tumor puncture and thermal ablation

Abstract Aim This study aimed to develop a novel tumor-bearing tissue phantom model that can be used for US/CT/MR-guided tumor puncture and thermal ablation. Methods The phantom model comprised two parts: a normal tissue-mimicking phantom and a tumor-mimicking phantom. A normal tissue phantom was prepared based on a polyacrylamide gel mixed with thermochromic ink. Moreover, a spherical phantom containing contrast agents was constructed and embedded in the tissue phantom to mimic a tumor lesion. US/CT/MR imaging features and thermochromic property of the phantom model were characterized. Finally, the utility of the phantom model for imaging-guided microwave ablation training was examined. Results The tumor phantom containing contrast agents showed hyper-echogenicity, higher CT numbers, and lower T2 signal intensity compared with the normal tissue phantom in US/CT/MR images. Consequently, we could locate the position of the tumor in US/CT/MR imaging and perform an imaging-guided tumor puncture. When the temperature reached the threshold of 60 °C, the phantom exhibited a permanent color change from cream white to magenta. Based on this obvious color change, our phantom model could clearly map the thermal ablation region after thermotherapy. Conclusions We developed a novel US/CT/MR-imageable tumor-bearing tissue model that can be used for imaging-guided tumor puncture and thermal ablation. Furthermore, it allows visual assessment of the ablation region by analyzing the obvious color change. Overall, this phantom model could be a good training tool in the field of thermal ablation.
Neutrophilsat the IL-10 Locus in Human Cutting Edge: An Inactive Chromatin

CassatellaBrandau, Flavia Bazzoni, Gioacchino Natoli and Marco A.Renato Ostuni, Kirsten Bruderek, Bastian Schilling, Sven Nicola Tamassia, Maili Zimmermann, Monica Castellucci,http://www.jimmunol.org/content/190/5/1921doi: 10.4049/jimmunol.1203022January 2013;J Immunol€2013; 190:1921-1925; Prepublished online 25MaterialSupplementary2.DC1. htmlhttp://www.jimmunol.org/content/suppl/2013/01/25/jimmunol.120302Referenceshttp://www.jimmunol.org/content/190/5/1921.full#ref-list-1This article cites 36 articles, 8 of which you can access for free at: Subscriptionshttp://jimmunol.org/subscriptionsInformation about subscribing to The Journal of Immunology is online at: Permissionshttp://www.aai. org/ji/copyright.htmlSubmit copyright permission requests at: Email Alertshttp://jimmunol.org/cgi/alerts/etocReceive free email-alerts when new articles cite this article. Sign up at:
Directed Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides

MASP-1 and MASP-2 are key activator proteases of the complement lectin pathway. The first specific mannose-binding lectin-associated serine protease (MASP) inhibitors had been developed from the 14-amino-acid sunflower trypsin inhibitor (SFTI) peptide by phage display, yielding SFTI-based MASP inhibitors, SFMIs. Here, we present the crystal structure of the MASP-1/SFMI1 complex that we analyzed in comparison to other existing MASP-1/2 structures. Rigidified backbone structure has long been accepted as a structural prerequisite for peptide inhibitors of proteases. We found that a hydrophobic cluster organized around the P2 Thr residue is essential for the structural stability of wild-type SFTI. We also found that the same P2 Thr prevents binding of the rigid SFTI-like peptides to the substrate-binding cleft of both MASPs as the cleft is partially blocked by large gatekeeper enzyme loops. Directed evolution removed this obstacle by replacing the P2 Thr with a Ser, providing the SFMIs with high-degree structural plasticity, which proved to be essential for MASP inhibition. To gain more insight into the structural criteria for SFMI-based MASP-2 inhibition, we systematically modified MASP-2-specific SFMI2 by capping its two termini and by replacing its disulfide bridge with varying length thioether linkers. By doing so, we also aimed to generate a versatile scaffold that is resistant to reducing environment and has increased stability in exopeptidase-containing biological environments. We found that the reduction-resistant disulfide-substituted l-2,3-diaminopropionic acid (Dap) variant possessed near-native potency. As MASP-2 is involved in the life-threatening thrombosis in COVID-19 patients, our synthetic, selective MASP-2 inhibitors could be relevant coronavirus drug candidates.
Introduction to Technology Management

Management of Technology is interdisciplinary fields that integrate science, engineering and management knowledge also with practice. Technology Management is set of management disciplines that allow organizations to manage their technological fundamentals to create competitive advantage. The main focus on technology part for manager is to create wealth. Technology management requires deep understanding of life cycles of technology, product, process and system. Technology management is also a tool to catalyze R&D. By providing R&D team in R&D organization to an increased extent, it can generate more science from existing science and more technology from existing technology. Technology management involve technological tool for national defense, national development and economic growth by resolving to make country a self-reliant, strong and technology developed country. Technology management involving those features can therefore act as a catalyst in propelling R&D programmed to achieve faster rates of technological growth.
The Essentials of Multiomics

Abstract Within the last decade, the science of molecular testing has evolved from single gene and single protein analysis to broad molecular profiling as a standard of care, quickly transitioning from research to practice. Terms such as genomics, transcriptomics, proteomics, circulating omics, and artificial intelligence are now commonplace, and this rapid evolution has left us with a significant knowledge gap within the medical community. In this paper, we attempt to bridge that gap and prepare the physician in oncology for multiomics, a group of technologies that have gone from looming on the horizon to become a clinical reality. The era of multiomics is here, and we must prepare ourselves for this exciting new age of cancer medicine.
Collecting Smart Meter Data via Public Transportation Buses

With advances in technology, wireless sensor networks (WSNs) have found new applications and their popularity has increased dramatically. In several applications, WSNs have the potential to replace wired data communication systems, e.g. in vehicular ad hoc networks (VANETs) they are the natural option for data communication. WSNs are also proposed for data communication in the emerging smart grid. In this study, the authors merge these two application domains, i.e. VANET and smart grids, and propose a novel solution for effective smart grid data communication. The authors’ proposed scheme achieves the task of collecting data from smart meters by utilising VANETs. Using network simulator-2 and with different routing protocols, the authors have performed simulations and shown the efficacy of their scheme in terms of average end-to-end delay and delivery ratio.
As-needed intranasal corticosteroid spray for allergic rhinitis: a systematic review and meta-analysis.

BACKGROUND As-needed intranasal corticosteroid spray (INCS) is commonly used by patients with allergic rhinitis (AR) who have suboptimal symptom control. This systematic review aimed to assess the effectiveness of as-needed INCS for treating AR. METHODOLOGY Systematic searches for randomized controlled trials studying the effects of as-needed INCS compared to regular INCS, as-needed antihistamine, or placebo were performed. Primary outcomes were total nasal symptom score (TNSS) and disease-specific quality of life (DSQoL). RESULTS Eight studies (882 participants) met the criteria. Regular use of INCS showed greater improvements than as-needed INCS in TNSS, DSQoL, nasal peak inspiratory flow, sneezing, and nasal congestion scores with small effect sizes. There were no differences between regular and as-needed INCS usage for ocular symptoms, symptom-free days, nasal itching, and rhinorrhea scores. As-needed INCS was superior to as-needed antihistamine and placebo with medium effect sizes. There were no differences in risk of adverse events between the groups in all three comparisons. CONCLUSIONS Regular use of INCS improved total nasal symptoms score and DSQoL better than as-needed INCS. However, as-needed INCS improved TNSS better than as-needed antihistamine and placebo. The effects of as-needed INCS were closer to regular INCS usage than to placebo or as-needed AH usage.
Effects of JZTX-V on the wild type Kv4.3 Expressed in HEK293T and Molecular Determinants in the Voltage-sensing Domains of Kv4.3 Interacting with JZTX-V

ABSTRACT JZTX-V is a toxin isolated from the venom of the Chinese spider Chilobrachys jingzhao. Previous studies had shown that JZTX-V could inhibit the transient outward potassium current of Kv4.2 and Kv4.3 expressed in Xenopus oocytes but had no effects on Kv1.2–1.4. However, the underlying action mechanism of JZTX-V on Kv4.3 remains unclear. In our study, JZTX-V could inhibit not only transient outward potassium currents evoked in small-sized DRG neurons but also Kv4.3-encoded currents expressed in HEK293T cells in the concentration and voltage dependence. The half maximal inhibitory concentration of JZTX-V on Kv4.3 was 9.6 ± 1.2 nM. In addition, the time course for JZTX-V inhibition and release of inhibition after washout were 15.8 ± 1.54 s and 58.8 ± 4.35 s. Electrophysiological assays indicated that 25 nM JZTX-V could shift significantly the voltage dependence of steady-state activation and steady-state inactivation to depolarization. Meanwhile, 25 nM JZTX-V decreased markedly the time constant of activation and inactivation but had no effect on the time constant of recovery from inactivation. To study the molecular determinants of Kv4.3, we performed alanine scanning on a conserved motif of Kv4.3 and assayed the affinity between mutants and JZTX-V. The results not only showed that I273, L275, V283, and F287 were molecular determinants in the conserved motif of Kv4.3 for interacting with JZTX-V but also speculated the underlying action mechanism that the hydrophobic interaction and steric effects played key roles in the binding of JZTX-V with Kv4.3. In summary, our studies have laid a scientific theoretical foundation for further research on the interaction mechanism between JZTX-V and Kv4.3.
Hypoxia induces proliferation via NOX4-Mediated oxidative stress and TGF-β3 signaling in uterine leiomyoma cells

Abstract Uterine leiomyomas, the most common tumors of the female reproductive system, are known to have a hypoxic microenvironment. However, the role of such environment in leiomyoma pathobiology remains unknown. The objective was to determine the effects of hypoxia on leiomyoma cells, and the mechanisms. We found that hypoxia induces proliferation and inhibits apoptosis in human leiomyoma cells. This pro-proliferative effect was accompanied by an increase in reactive oxygen species (ROS) generation and the expression of NADPH oxidase 4 (NOX4). The specific NOX4 inhibitor GLX351322 abrogated this hypoxia-induced ROS generation, cellular proliferation, and apoptosis inhibition. To further investigate the mechanism of NOX4-mediated proliferation, we treated leiomyoma cells grown in normoxia with media from leiomyoma cells cultured under hypoxia. This resulted in increased ROS generation and NOX4 expression, suggesting the hypoxia-induced effects are mediated by an autocrine mechanism. We worked to identify the nature of this autocrine factor. We found that the expression of TGF-β3 and its downstream signaling target pSmad3, are increased in hypoxic leiomyoma cells. To examine the hypothesis that TGF-β3 is, at least, a part of this autocrine mechanism, we treated hypoxic leiomyoma cells with the HIF-1α inhibitor KC7F2 which we discovered to ameliorate the hypoxia-induced TGF-β3 expression. Furthermore, pharmacologic inhibition with the TGF-β/Smad inhibitor SB431542 reduced hypoxia-induced NOX4 expression and ROS generation and attenuated cell proliferation. Thus, we have identified a novel mechanism by which hypoxia induces proliferation in leiomyoma cells. This finding adds to our understanding of leiomyoma pathobiology and can help in identifying new therapeutic targets. Graphical Abstract A cartoon illustrating the mechanism by which hypoxia induces NOX4-mediated leiomyoma cell proliferation via ROS generation and TGF-β3 pathway. HIF-1α, hypoxia inducible factor 1 alpha; TGF-β3, transforming growth factor beta 3; TGFβR, transforming growth factor beta receptor; NOX4, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4; ROS, reactive oxygen species.
Synchrotron XRF Analysis Identifies Cerium Accumulation Colocalized with Pharyngeal Deformities in CeO2 NP-Exposed Caenorhabditis elegans

A combination of synchrotron radiation-based elemental imaging, in vivo redox status analysis, histology, and toxic responses was used to investigate the uptake, biodistribution, and adverse effects of Ce nanoparticles (CeO2 NP; 10 nm; 0.5–34.96 mg Ce L–1) or Ce(NO3)3 (2.3–26 mg Ce L–1) in Caenorhabditis elegans. Elemental mapping of the exposed nematodes revealed Ce uptake in the alimentary canal prior to depuration. Retention of CeO2 NPs was low compared to that of Ce(NO3)3 in depurated individuals. X-ray fluorescence (XRF) mapping showed that Ce translocation was confined to the pharyngeal valve and foregut. Ce(NO3)3 exposure significantly decreased growth, fertility, and reproduction, caused slightly reduced fecundity. XRF mapping and histological analysis revealed severe tissue deformities colocalized with retained Ce surrounding the pharyngeal valve. Both forms of Ce activated the sod-1 antioxidant defense, particularly in the pharynx, whereas no significant effects on the cellular redox balance were identified. The CeO2 NP-induced deformities did not appear to impair the pharyngeal function or feeding ability as growth effects were restricted to Ce(NO3)3 exposure. The results demonstrate the utility of integrated submicron-resolution SR-based XRF elemental mapping of tissue-specific distribution and adverse effect analysis to obtain robust toxicological evaluations of metal-containing contaminants.