Miracle-dz/UniFAR-FTUs huggingface dataset:
A review on putative mechanism of action of nootropic herb Bacopa monnieri

Bacopa monnieri (BM) has been used by ayurvedic medical practitioners for centuries for a variety of purposes, including improving memory, reducing anxiety and treating epilepsy Bacopa monnieri (L) Penn. (Family: Scrophulariaceae) commonly known in both India and Bangladesh as ‘Brahmi’ is an ancient and renowned medicinal plant with legendary reputation as a memory vitalizer (Brimson et al ., 2021) in the traditional system of medicine (Ayurveda). Brahmi is classified as medhya rasayana, a drug that is supposed to counteract the effect of mental stress and improved the intelligence and memory function. Brahmi have an effect on various neurodegenerative diseases as they modulate signaling pathways (Maity, 2019). Brahmi is found to be effective in the case of anxiety and neurosis. Numerous studies suggested that B. monnieri’s bioactive components (i.e. bacosides) protect the brain against oxidative damage and age related cognitive deterioration with several mechanisms of action (Manap, 2019). It possesses anti-inflammatory, analgesic and anti-pyretic activity. It is also used to treat asthma, insanity epilepsy, enlargement of spleen, snakebite, rheumatism, leprosy, eczema, ring worm and as a diuretic and cardio tonic. Present review will amalgamate molecular neuroscience with behavioral research and also to examine the prominent effects of standardized extract of Bacopa monnieri on the action of the central nervous system.
On the Alignment of Safety and Security for Autonomous Vehicles

—Safety is the primary requirement and the key chal- lenge in autonomous vehicles. Any accidental failures (safety issue) and/or intentional attacks (security issue) may result in severe injury or loss of life. Thus, any missing consideration on either failures or attacks may lead to terrible consequence. Safety and security are inter-related and, therefore, have to be aligned early in the development process. International standards, International Organization for Standardization (ISO 26262), and Society of Automotive Engineers (SAE J3061), have been proposed for vehicle safety and security. However, they do not address all the aspects of autonomous vehicles as they rely on a human driver controlling the vehicle. In high automation vehicles (level 3 or above, as deﬁned by the international standard SAE J3016), the autonomous driving system is fully responsible for driving the vehicle. Thus, different driving automation levels have to be taken into consideration when designing autonomous vehicle safety and security. We propose an approach for aligning safety and security lifecycles, based on SAE J3061, SAE J3016, and ISO 26262 standards at an early development phase. The proposed approach uses the Failure, Attack and Countermeasure (FACT) graph to connect safety failures, security attacks, and the associated countermeasures. The proposed approach is helpful for designing or tailoring the safety and security processes, and selecting appropriate countermeasures for autonomous vehicles taking into consideration the driving automation levels.
User Centered Design for persons with disabilities

The user centered design process is a framework built on methods aiming at including the user in the design process. When designing a system that is going to be used by persons suffering from severe disabilities, a number of unique difficulties are introduced. This thesis investigates what particular issues that has to be considered when designing for eye tracking based interaction and how user inclusion can be achieved despite the presence of severe disabilities. Persons from three habilitation centers in the Stockholm area were included in the study which was implemented as an iterative design process, including a number of methods common within user centered design. The result of this study indicates that many of the well-recognized methods in user centered design can be used when including users with cerebral palsy. Focus is shifted slightly away from the user towards other persons in the vicinity. To achieve high usability the system must facilitate individual customizations of the interface regarding the colors, sizes and placements of objects. A method of two step selection, reducing the numbers of unintentional selections, is also presented.
a Effect of a ten-week Nordic Walking exercise program on serum electrolyte concentration and plasma acid-base balance in postmenopausal women with overweight or obesity

Introduction : The effect of exercise program on serum electrolyte concentration and gas partial pressure has not previously been reported. Aim: The aim of this study was to estimate the effect of a 10-week Nordic Walking exercise program on these parameters. Patients and methods: The subjects were 32 postmenopausal women with overweight or obesity were studied. Before the start of the exercise program and directly after it had finished, blood samples were taken to determine sodium, potassium, magnesium, calcium, phosphorus, and capillary gasometry parameters. Results: After the 10-week exercise program, a significant decrease in serum concentrations of sodium, magnesium, calcium, capillary potential of hydrogen (pH), capillary partial pressure of carbon dioxide (pCO 2 ), bicarbonate (HCO 3 ), and base excess (BE), as well as an increase in potassium, chloride, capillary partial pressure of oxygen (pO 2 ), and hemoglobin oxygen saturation (SaO 2 ) levels was found. The proportional change in sodium serum concentrations correlated significantly with delta BMI, and potassium and calcium proportional alterations after the exercise program had finished correlated with proportional changes in albumin concentration. Conclusions: A 10-week Nordic Walking exercise program resulted in statistically significant changes in almost all serum electrolyte concentration, but only to a small extent and probably without clinical importance. The improvement in oxygen partial pressure in capillary blood after the exercise program shows a potentially complex, favorable effect of a prolonged exercise program and requires further study.
The focus of the presented analysis is on the 'operational' evaluation as defined in the AQMEII-P1 project protocol. With regard to ozone, a discussion of ozone

In the scope of the AQMEII Phase 1 project the GEM-AQ model was run over Europe for the year 2006. The modelling domain was defined using a global variable resolution grid with a rotated equator and uniform resolution of 0.2◦ × 0.2◦ over the European continent. Spatial distribution and temporal variability of the GEM-AQ model results were analysed for surface ozone and PM10 concentrations. Model results were compared with measurements available in the ENSEM5 BLE database. Statistical measures were used to evaluate performance of the GEM-AQ model. The mean bias error, the mean absolute gross error and the Pearson correlation coefficient were calculated for the maximum 8 h running average ozone concentrations and daily mean PM10 concentrations. The GEM-AQ model performance was characterised for station types, European climatic regions, and seasons. The best performance for ozone was obtained at suburban stations and the worst per10 formance was obtained for rural stations where the model tends to underestimate. The best results for PM10 were calculated for urban stations, while over most of Europe concentrations at rural sites were too high. Discrepancies between modelled and observed concentrations were discussed in the context of emission data uncertainty as well as the impact of large scale dynamics and circulation of air masses. Presented analyses suggest that interpretation of modelling results is enhanced when 15 regional climate characteristics are ta ken :::: taken into consideration.
Edinburgh Research Explorer Analysis of the impact of Colony Stimulating Factor (CSF)-1 administration in adult rats using a novel Csf1r-mApple reporter

Macrophages are present in large numbers in every tissue in the body where they play critical roles in development and homeostasis. They exhibit remarkable phenotypic and functional diversity, underpinning their adaptation to specialized roles in each tissue niche. CSF1, signaling through the CSF1 Receptor (CSF1R), which is restricted to monocytemacrophage lineage cells in adults, is a critical growth factor controlling macrophage proliferation, differentiation and many aspects of mature macrophage function. We have generated a macrophage reporter rat, utilizing a construct containing elements of the mouse Csf1r promoter and the highly conserved Fms intronic regulatory element (FIRE) to drive mApple fluorescent protein expression. Csf1r-mApple was robustly expressed in monocytemacrophage lineage cells in rat bone marrow, peripheral blood and tissues, with detectable expression in granulocytes and B cells and no evidence of expression in hematopoietic precursors or non-hematopoietic cells. Here, we use the Csf1r-mApple transgene to highlight and dissect the abundance and heterogeneity of rat tissue macrophage populations, and to demonstrate parallel increases in blood monocytes and multiple tissue macrophage populations, including bone marrow, liver, spleen and lung, in response to CSF1 treatment in vivo. The Csf1r-mApple rat is a novel tool enabling analysis of rat macrophages in situ by direct imaging and providing an additional phenotypic marker to facilitate exploration of rat tissue macrophage phenotypic and functional heterogeneity.
Surveying the Incorporation of IoT Devices into Cybersecurity Risk Management Frameworks

—This paper reviews the state of the art for incorporating Mobile Devices, Industrial Control Systems, and Internet of Things systems into present risk analysis framework models. Internet of Things devices present unique risks to a network due to their highly connective and physically interactive nature. This physical inﬂuence can be leveraged to access peripherals beyond the immediate scope of the network, or to gain unauthorized access to systems which would not otherwise be accessible. A 2017 Government Accountability Ofﬁce report on the current state of Internet of Things device security noted a lack of dedicated policy and guidance within the United States government cybersecurity risk assessment construct and similar private sector equivalents. Surveyed in this paper are 28 original frameworks designed to be implemented in enterprise networks. In this research the comparison of frameworks is analyzed to assess each system’s ability to provide risk analysis for Internet of Things devices. The research categories are level of implementation, quantitative or qualitative scoring matrix, and support for future development. This survey demonstrates there are few risk management frameworks currently available which attempt to incorporate both cyber-physical systems and enterprise architecture in a large scale network.
A Plant Generalist or Not : Revisiting Xylella fastidiosa Systematics

In 2013, an outbreak of Xylella fastidiosa was first identified in Apulia (southeastern Italy) in olive trees severely affected by a novel dis- easedenotedOliveQuickDeclineSyndrome( Complesso delDisseccamentoRapidodell’Olivo , CoDiROinItalian). CoDiROwasfirstwidely observed in 2010 and is characterized by extensive scorching and desiccation of leaves and twigs. At a preliminary examination, many of such trees appeared to be impacted by the presence of three different agents: (i) the leopard moth ( Zeuzera pyrina ), which drills galleries in the branches and trunks of olives; (ii) a set of xylem-inhabiting fungi of different genera ( Phaeoacremonium and Phemoniella , in particular) (Nigro et al. 2014), which invade the sapwood taking also advantage of the moth galleries; and (iii) the bacterium X. fastidiosa . As time passed and a better insight into the disease was gained with field and laboratory observations, it became evident that the role of the leopard moth is minor, whereas the fungi could play the role of aggravators. Although the etiological role of X. fastidiosa is yet to be determined, the finding of this quarantine bacterium in the European Union prompted urgent investigations to address the many open questions and to en- force actions for its containment to avoid further spread in the neighboring areas and in other countries. proposed. surveys in the shown under natural field extensive survey to assess the presence of infections in grapevines and citrus trees in the heavily presence of in both
Particularity of PlaSticity characteriSticS of fine glacial materialS (north chicago area)

The representation of plasticity characteristics on Casagrande plasticity chart of glacial material samples, from an investigated area north of Chicago, IL, USA, confirmed the known alignment along the T line (Boulton and Paul, 1976) for the category of glacial materials. The goal of the present study was to identify the factors responsible for the plastic behavior of the glacial materials. We consider that this particular characteristic of plasticity is the result of grain size distribution with a minimum inter-granular space created by genetic glacio-clastic processes. Synergetic association between the minimum inter-granular void grain ratio, and the minimum efficient content of clay pallets around bigger grains, have an impact over plasticity behavior, lowering both liquid limits LL, and plasticity limit PL, but increasing the gap between these limits (the plasticity index).
ECG Biometrics using Intuitive Bases and Support Vector Machines

ECG Biometrics using Intuitive Bases and Support Vector Machines Peter Sam Raj Master of Applied Science Graduate Department of Electrical and Computer Engineering University of Toronto 2014 In this thesis, a parts-based intuitive customized basis has been proposed using the non-negative sparse coding method for feature templates of the electrocardiogram(ECG) signal for biometrics. Combining with two classifier choices, two algorithms are proposed with complexity considerations for practical application scenarios using dependent classification. Using the proposed methods, a large scale fingertips ECG database was evaluated for biometrics potential, while observing the effect of user population size variation. The lowest known equal error rate (EER) for large-scale ECG biometrics was reported, which is 2.59% for 1012 users. Two unprecedented databases containing signals from a single arm were collected and analysed for biometrics application, following evidence of ECG pulses in the upper left arm. They reported encouraging EERs, based on the proposed methods. Best EERs obtained were 3.26% in the single-lead, and 6.97% for the multi-lead signals, both for ‘sitting’ posture.
THE INFLUENCE OF THE MOLAR BAND AND BUCCAL TUBE ON PERIODONTAL HEALTH IN ORTHODONTIC TREATMENT

Objective: To compare the side effects of the molar bands and buccal tubes on periodontal health during orthodontic treatment. Methods: We selected 42 patients who treated with the fixed appliance, they all in the age range of 12-16 years, for each one choosing two first molars and one of the second molars in mandible as research objects, it is a total of 126 teeth. We bonded both a buccal tube and a molar band in the first molars of mandible, using the stochastic method to decide which side bonded the buccal tube, bonding it in the middle of the tooth crown. Take the second molar in buccal tube side as a blank control. In this study, 84 first molars were selected as the experimental group and 42 second molars without fixed appliance as the control group. The experimental group can be divided into two small groups. Buccal group, the 42 molars which used the buccal tubes in orthodontic treatment. Moral group, the 42 teeth which used the molar bands in orthodontic treatment. Furthermore. Gingival index and Pocket probing depth were recorded for clinical evaluation, IL-1 and IL-6 were tested use ELISA in this study. Results: In this study, there was no difference in all of the indexes among three groups before our experiment. After placing fixed appliance 6 months and 12 months, both of the experimental groups (buccal tube group and molar band group) showed that GI, PPD continued to increase. Compared with baseline, they had significant difference (P < 0.05), although there was no significant difference between buccal tube group and molar band group (P>0.05), the mean value of the GI, PPD in molar band group was larger than buccal tube group. After placing fixed appliance 6 months and 12 months, both of the experimental groups showed that IL-1 and IL-6 continued to increase. Compared with baseline, they had a significant difference (P < 0.05). In addition, there was a significant difference between IL-1 and IL-6 between buccal tube group and molar band group (P<0.01). It showed that inflammatory substances in the gingiva groove liquid increased during the treatment. Conclusion: In orthodontic treatment, buccal tubes caused less inflammatory response on periodontal health than molar bands, which was helpful to achieve better treatment effect. We concluded that buccal tube was more conducive to the periodontal health than molar band.
Challenges of Single-User Cross Reality Applications

Cross-reality (CR) is defined as "the transition between or concurrent usage of multiple systems on the RV continuum. "[1] Our work aims to develop the guidelines and processes to create the single-user CR application. In this position paper, we present three scenarios derived from the definition of CR, focusing on single-user CR applications. For each scenario, we discuss some challenges that need to be considered in order to enhance the single-user CR experience.
TeSum: Human-Generated Abstractive Summarization Corpus for Telugu

Expert human annotation for summarization is definitely an expensive task, and can not be done on huge scales. But with this work, we show that even with a crowd sourced summary generation approach, quality can be controlled by aggressive expert informed filtering and sampling-based human evaluation. We propose a pipeline that crowd-sources summarization data and then aggressively filters the content via: automatic and partial expert evaluation. Using this pipeline we create a high-quality Telugu Abstractive Summarization dataset (TeSum) which we validate with sampling-based human evaluation. We also provide baseline numbers for various models commonly used for summarization. A number of recently released datasets for summarization, scraped the web-content relying on the assumption that summary is made available with the article by the publishers. While this assumption holds for multiple resources (or news-sites) in English, it should not be generalised across languages without thorough analysis and verification. Our analysis clearly shows that this assumption does not hold true for most Indian language news resources. We show that our proposed filtration pipeline can even be applied to these large-scale scraped datasets to extract better quality article-summary pairs.
Palaeomagnetic evidence for uniﬁcation of the North and West Australian cratons by ca. 1.7 Ga: new results from the Kimberley Basin of northwestern Australia

SUMMARY A palaeomagnetic study of the Elgee Formation red siltstones and shales in the Palaeoproterozoic Kimberley Basin of northwestern Australia has been carried out. All seven sampling sites revealed an extremely stable magnetic remanence carried by haematite. The age of the formation is conﬁned by precise SHRIMP U–Pb ages of early diagenetic xenotime from rocks both above and below it to be 1704 + 7 / − 14 Ma, but this may represent a minimum age. The youngest detrital zircon grains in the underlying formation provide a maximum age of 1786 ± 14 Ma for the formation. The extreme stability of the remanence, the dissimilarity of the remanent direction from expected younger palaeomagnetic directions, and the lack of regional overprint in the 1790 ± 4 Ma Hart Dolerite just north of the study region support a primary origin for the remanence. A marginally positive fold test also supports a primary origin. The mean direction of D = 92.2 ° , I = 14.9 ° , a 95 = 6.4 ° gives a palaeopole at 4.4 ° S, 210.0 ° E with dp = 3.3 ° , dm = 6.5 ° . This pole, a previously reported palaeopole from the Hart Dolerite and ca. 1700 Ma overprint poles from the Pilbara Craton all agree with palaeopoles of similar ages from the McArthur Basin of northern Australia. Palaeomagnetic results thus suggest that the North and West Australian cratons were possibly joined together by approximately 1.7 Ga. Precambrian. robust palaeomagnetic examination of Precambrian palaeo-
Bias Detection in Czech News

Automatic detection of bias in media represents a possible way to more objective and factual writing. This work focuses on media bias and addresses the problem of binary classification of media bias in the Czech news environment. The literature and methodology for different aspects of bias are reviewed. Then, a set of datasets related to media bias is collected and analyzed. Utilizing machine translation, eight parallel Czech datasets are presented, one of which being a largescale dataset of 360k sentences. Additionally, a novel Czech dataset CWNC (Czech Wiki Neutrality Corpus) for bias detection with 5766 sentences is automatically extracted from Wikipedia. The following experiments then show the effects of pre-training on combinations of currently available datasets, suggesting a positive effect of pre-training on datasets focused on subjectivity. Czech BERT-based model with the best parameters and setting then achieves an F1 score of 80.2% on the selected target dataset. Finally, a trained classifier is utilized to classify real-world data from various news sources.
Tenofovir Induced Hepatitis B Surface Antigen Loss and Seroconversion in Two Patients with E-Antigen Negative Chronic Hepatitis B Infection: Case Series

Two cases of HBsAg seroconversion, following treatment with Tenofovir disoproxil fumarate, a nucleotide reverse transcriptase inhibitor, were reported amongst the patients with chronic hepatitis B infection attending gastrointestinal clinic in a tertiary hospital. The patients had liver biopsy done during their evaluation, following which they were commenced on the medication. Tenofovir was taken for four years and two years respectively before they lost the hepatitis B surface antigen and developed quantifiable antibodies to the surface antigen (Anti-HBs). Loss of HBsAg is a rare event, and seroconversion in patients with CHB is even less common. Studies have shown that HBsAg loss and seroconversion is less likely with patients on the oral antiviral agents compared with pegylated interferon. Although, both patients had very low pretreatment hepatitis B viral load which might indicate strong immune response to the virus, a factor that could have been partly responsible for the seroconversion. They however, had significant liver fibrosis on histology prior to their seroconversion and will require hepatocellular cancer surveillance until normalization of the liver histology can be ascertained.