Miracle-dz/UniFAR-FTUs huggingface dataset:
Semantic rules for capability matchmaking in the context of manufacturing system design and reconfiguration

ABSTRACT To survive in dynamic markets and meet the changing requirements, manufacturing companies must rapidly design new production systems and reconfigure existing ones. The current designer-centric search of feasible resources from various catalogues is a time-consuming and laborious process, which limits the consideration of many different alternative resource solutions. This article presents the implementation of an automatic capability matchmaking approach and software, which searches through resource catalogues to find feasible resources and resource combinations for the processing requirements of the product. The approach is based on formal ontology-based descriptions of both products and resources and the semantic rules used to find the matches. The article focuses on these rules implemented with SPIN rule language. They relate to 1) inferring and asserting parameters of combined capabilities of combined resources and 2) comparison of the product characteristics against the capability parameters of the resource (combination). The presented case study proves that the matchmaking system can find feasible matches. However, a human designer must validate the result when making the final resource selection. The approach should speed up the system design and reconfiguration planning and allow more alternative solutions be considered, compared with traditional manual design approaches.
Ice‐Marginal Proglacial Lakes Across Greenland: Present Status and a Possible Future

Ice‐marginal lakes can affect glacier dynamics but are ignored in studies of the evolution of the Greenland ice sheet (GrIS) and of peripheral mountain glaciers and ice caps (PGICs). Here we show that lakes occupy 10% of the GrIS ice margin and occur on 5% of PGICs. Ice velocity at the GrIS margin is enhanced by ∼ 25% at lakes versus on land. Mean ice discharge into lakes is ∼4.9 Gt.yr, which is ∼1% of ice discharged through marine termini. We locate thousands of subglacial overdeepenings within which 7,404 km2 of future lakes could form, all of which will be ice‐marginal at some time. Future lakes in the west and east will be restricted to the margin of the GrIS and within alpine valleys, respectively. This status and possible future leads us to contend that lakes should be incorporated into projections of Greenland ice loss.
UWB Microstrip Patch Antenna with 5G Lower Band Notch Characteristics

For fifth generation (5G) lower band wireless application at a frequency of (4.5–5.5) GHz, recently ASEAN region countries have suggested 5G forums and band rejection antennas for 5G (4.5–5.5) GHz lower band. A UWB antenna has been constructed and suggested by use of the Roger RT5880 with defected ground on a rectangular radiating patch and a ring shape type of resonator (RSR) on ground plane to achieve the desired performance. It was decided to construct a band rejection within UWB antenna for 5G which included adding a rectangular slot on the radiating patch as well as placing RSR to the ground plane of the proposed antenna. The results support the theory that the antenna is capable of transmitting and receiving in the UWB except band notched bandwidth. Additionally, the results show that the antenna possesses good performance across the whole UWB spectrum with a gain of 4.6 dBi. This, in addition to its ability to support the lower 5G band notched, is why the suggested antenna is a good contender for future 5G wireless implementations within UWB bandwidth.
A Small CO2 Leakage May Induce Seismicity on a Sub‐Seismic Fault in a Good‐Porosity Clastic Saline Aquifer

Despite public concerns, only a few CO2 injections into saline aquifers have reported microseismicity. We analyze passive seismic monitoring of a small (15,000 tonnes and 0.15 MPa pressure) injection of supercritical CO2‐rich mixture for Stage 2C of the CO2CRC Otway Project (Victoria, Australia), which induced 19 detectable events with maximum moment magnitude MW‐0.5. The locations and dynamic parameters of the triggered events indicate a reactivation of a small fault patch where CO2 flowed through the fault. Time‐lapse seismic images of the plume and reservoir simulations show that the reactivation occurred when the CO2 plume reached this fault. This might be indicative of a fault weakening by the plume that enabled subsequent reactivation by pressure variations. Our observations suggest that a leakage from a commercial‐scale storage may trigger felt seismicity in the overburden without strong overpressure, thus, the de‐risking workflows should involve a detailed study of small faults.
Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies

SETD2, a lysine N-methyltransferase, is a histone methyltransferase that plays an important role in various cellular processes and was identified as a target of interest in multiple myeloma that features a t(4,14) translocation. We recently reported the discovery of a novel small-molecule SETD2 inhibitor tool compound that is suitable for preclinical studies. Herein we describe the conformational-design-driven evolution of the advanced chemistry lead, which resulted in compounds appropriate for clinical evaluation. Further optimization of this chemical series led to the discovery of EZM0414, which is a potent, selective, and orally bioavailable inhibitor of SETD2 with good pharmacokinetic properties and robust pharmacodynamic activity in a mouse xenograft model.
NUTRACEUTICAL ASPECTS OF AZOLLA: A LOW-COST ORGANICINPUT FOR LIVESTOCK

Livestock has a significant role in the world economy. Livestock is the major source of livelihood for about 20.5 million people in India and livestock resources contribute 4.11% of the country's GDP and 25.6% of total agriculture GDP. On the other hand, there is a huge gap between demand and supply of feed and fodder in India, which can be reduced by exploring natural feed resources as supplements. To complete the shortage of feed and optimum production of livestock, it is significant to explore some non-conventional nutritive feed resources. The aquatic fern, Azolla has been identified as one of the most efficient substitutes for livestock as it can be easily digested due to its low lignin with high protein content having especially essential amino acid lysine. Its unique nutrient aspects make it an ideal feed for livestock, poultry, goat, fish, and pigs. Nutraceutical aspects of Azolla bio-feed technology will be taken up in a big way by the dairy farmers, especially, by those who experience land scarce conditions for fodder production.
Total Phenolic, Flavonoid Content, and Antioxidant Activity of Justicia tranquebariensis LF and Cycas Beddomei Dyer. Leaves

Polyphenolics such as tannins and flavonoids are proved as powerful antioxidants to resolve cellular stress, sustain homeostasis in the body and prevent stress-associated disorders. Plant-based medicine gained importance due to its safety margin and multiple benefits. Regular intake of antioxidants is an alternative to avoid serious illness. The current investigation is aimed to measure the phenolic, flavonoid content, the antioxidant activity of Justicia tranquebariensis L.f. and Cycas beddomei leaves. The selected plants are used by tribes and traditional medicine to cure various diseases. Total phenolic content was estimated using the Folin–Ciocalteu colorimetric method, taking gallic acid as standard. At the same time, total flavonoid content was determined by aluminum chloride colorimetric assay using Rutin as standard.The absorbance was measured at 760 nm and 510 nm, respectively. Antioxidant activity was measured by two In vitro methods (DPPH and NO free radical scavenging assay) using standard protocols, where Ascorbic acid served as a reference standard. Results disclosed that the total phenolic content for the methanolic extracts of C. beddomei (36.14 ± 1.72) and J. tranquebariensis (28.57 ± 0.91) was found to be higher than petroleum ether extracts. Similarly, C. beddomei (28.13 ± 2.48) is richer in flavonoids than Jtranquebariensis (20.32 ± 1.24). In DPPH assay, methanolic extract C. beddomei (78.21%) is more effective to inhibit the free radicals than J. tranquebariensis (73.05%) with IC50 values 41. 55µg/ml and 59.52 µg/ml respectively at higher doses that are comparable to standard ascorbic acid (84.34%, IC50 =63.27 µg/ml). Similarly, in NO free radical scavenging assay, methanolic extract of C. beddomei (72.54%) stood best among all to scavenge the free radicals with IC50 values 50.06 µg/ml, whereas ascorbic acid is found to inhibit 83.26% with IC50 values 39. 75µg/ml. The presence of various secondary metabolites such as alkaloids, carbohydrates, phenols, steroids, terpenoids, glycosides, saponins, especially tannins and flavonoids, either alone or in combination, may be responsible for the observed scavenging property. The quantity of the phenolic compounds and flavonoids can be directly correlated to the exhibited activity.
An Empirical Study of Mobile Application Usability: A Unified Hierarchical Approach

Abstract Mobile app usability has been attracting the attention of academics and practitioners for sometime because well-designed mobile apps can build a close link between businesses and users in addition to enhancing user experiences. To better understand mobile app usability, this study develops a unified hierarchical approach that characterizes mobile app usability from the high level of “usability principles” to the intermediary level of “usability attributes” to the detailed level of “usability features” to assess the usability of current mobile apps from different categories. Using an online survey, we identified a set of usability design features that are common to all categories of apps. Furthermore, the study identifies a set of important and less important usability features within specific mobile app categories. In addition to the practical implications consisting of insights for mobile app design, the study found important relationships among usability principles, attributes, and features.
Median Effective Concentration of Ropivacaine for Femoral Nerve Block Maintaining Motor Function During Knee Arthroscopy in Two Age Groups

Background Femoral nerve block combined with general anesthesia is commonly used for patients undergoing knee arthroscopy in ambulatory care centers. An ideal analgesic agent would selectively (differentially) block sensory fibers, with little or no effect on motor nerves. Ropivacaine is considered to cause less motor block than others. This study investigated the median effective concentration (EC50) of ropivacaine for differential femoral nerve block in adults either younger or older than 60 years. Methods Patients with American Society of Anesthesiologists physical status I–III and scheduled for knee arthroscopy were categorized as 18- to 60-years-old (Group 1), or older than 60 years (Group 2). Surgeries were performed under general anesthesia combined with femoral nerve block via 22 mL ropivacaine. The EC50 of ropivacaine for differential femoral nerve block was determined using the up-and-down method and probit regression. The primary outcome was the EC50 (95% confidence interval [CI]) of the 2 groups. Data on the sensory block, analgesic effect, complications, and hemodynamics during surgery were also recorded. Results The EC50 of 22 mL ropivacaine for differential femoral nerve block of Group 1 (0.124%, 95% CI 0.097–0.143%) was significantly higher than that of Group 2 (0.088%, 95% CI 0.076–0.103%). The sensory block and hemodynamic data of the 2 groups were comparable. None of the patients experienced neurological complications. Conclusion The EC50 of ropivacaine administered for differential femoral nerve block during knee arthroscopy was lower in patients older than 60 years, relative to younger adults.
Are Hair Cortisol Levels of Humans, Cats, and Dogs from the Same Household Correlated?

Simple Summary Dogs and cats are animals that have been accompanying humans for many years. There is no doubt that they are emotionally connected with people, although each of them in their own way. The study attempts to assess the emotional relationship between humans, dogs, and cats living in one household on the basis of the correlations between the hair cortisol level. The study involved 25 women who had at least one dog and at least one cat at home. Based on the study conducted, no significant correlation was found between the level of cortisol in the hair of the owners and their pets. There were, however, some interesting differences depending on the degree of emotional connection and the frequency of interactions. Abstract Human–animal interactions and the emotional relationship of the owner with the pet are the subjects of many scientific studies and the constant interest of not only scientists but also pet owners. The aim of this study was to determine and compare the hair cortisol levels of dogs, cats, and their owners living in the same household. The owners were asked to complete a questionnaire concerning the frequency of their interactions with pets and emotional relationship with each of their cats and each of their dogs. The study involved 25 women who owned at least one dog and at least one cat. In total, 45 dogs and 55 cats from 25 households participated in the study. The average level of hair cortisol of the owners was 4.62 ng/mL, of the dogs 0.26 ng/mL, and in the hair of cats 0.45 ng/mL. There was no significant correlation between the hair cortisol level of the owner and dog or the owner and the cat and between dogs and cats living together. A significant positive correlation was observed between the hair cortisol level in the owner and the pet, for dogs in which the owner performs grooming treatments once a week and for cats which are never kissed. Although our study did not find many significant correlations, studies using other stress markers might have yielded different results.
Industrial Internet of Things Anti-Intrusion Detection System by Neural Network in the Context of Internet of Things for Privacy Law Security Protection

Today, the Industrial Internet of Things (IIoT) and network technology are highly developed, and network data breaches occur every year. Therefore, an anti-intrusion detection system has been established to improve the privacy law security protection of IIoT. In the adversarial network, the security performance requirements and structural system of the Internet of Things have high-strength requirements. The network system must adopt a system with strong stability and a low data loss rate. After comparing a large number of network structures, the initial network technology in deep learning is adopted. The Convolutional Neural Network (CNN) technology for handwritten character recognition optimizes and upgrades the LeNet-5 network, and the new LeNet-7 is built. Additionally, three network technologies are combined, and an IIoT anti-intrusion detection system is constructed. The performance of the system is tested and verified. The model has high data accuracy, detection rate, and low false-positive rate. The model’s generality on high-performance data is validated and compared with privacy-aware task offloading methods, achieving the best performance. Therefore, the system can be applied to the data privacy law security protection of IIoT.
IL-36 is Closely Related to Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease

Background Interleukin (IL)-36α, IL-36β, and IL-36γ belong to the IL-36 family and play an important role in the pathogenesis of many diseases. Chronic obstructive pulmonary disease (COPD) may be correlated with IL-36; however, the specific role of IL-36 in COPD is unclear. In this study, we aimed to clarify whether IL-36 could be an indicator for determining COPD severity and the specific nature of the pro-inflammatory effects of IL-36 in COPD. Methods A total of 70 patients with COPD and 20 control subjects were included in this study. We collected peripheral blood samples from both the groups, analyzed the blood cell fractions by routine blood examination, and measured the serum levels of IL-36α, IL-36β, and IL-36γ by performing polymerase chain reaction and enzyme-linked immunosorbent assay. In addition, the correlation between the number of neutrophils and eosinophils and the level of IL-36 was also analyzed. Results We found that level of IL-36 in patients with COPD was positively correlated with the number of neutrophils but not with eosinophils, whereas the correlation was not found in the control group. Moreover, the level of IL-36 was negatively correlated with the level of lung function of patients with COPD, and the levels of IL-36α, IL-36β, and IL-36γ increased with advancing disease severity. Conclusion In COPD, the pro-inflammatory effect of IL-36 is closely related to neutrophils, and hence, IL-36 might be considered a novel biomarker for determining COPD severity.
Tumor Response and Nomogram-Based Prognostic Stratification for Hepatocellular Carcinoma After Drug-Eluting Beads Transarterial Chemoembolization

Purpose To explore the tumor response and propose a nomogram-based prognostic stratification for hepatocellular carcinoma (HCC) after drug-eluting beads transarterial chemoembolization (DEB-TACE). Patients and Methods From the database of two centers, patients who received DEB-TACE as an initial treatment were enrolled and divided into the training and validation sets. The tumor response after DEB-TACE was estimated according to the Modified Response Evaluation Criteria in Solid Tumors. Using the independent survival predictors in the training set, a nomogram was constructed and validated internally and externally by measuring concordance index (C-index) and calibration. A prognostic stratification based on the nomogram was established. Results A total of 335 patients met the inclusion criteria for the study. Alkaline phosphatase level, tumor maximum diameter, tumor capsule and portal vein invasion were interrelated with the achievement of complete release after DEB-TACE. Alpha-fetoprotein level, Child-Pugh class, tumor maximum diameter, tumor number, tumor extent and portal vein invasion were integrated into the nomogram. The nomogram demonstrated good calibration and discrimination, with C-indexes of 0.735 and 0.854 and higher area under the curve (AUC) than BCLC and CNLC staging systems in the internal and external validation sets. The prognostic stratification classified patients into three different risk groups, which had significant differences in survival, complete release and objective response rate between any two groups (P < 0.05). Conclusion The nomogram-based prognostic stratification has a good distinction and may help to identify the patients benefiting from DEB-TACE.
Introduction to the special section on social norms and behavioral development

This introduction outlines the goals for the special section on social norms and behavioral development. The study of social norms has attracted much interest in peer relations research, and has turned attention to group-level processes, often defined based on the classroom, which create and sustain shared meanings that impact adolescent behavioral and social adjustment. Norms can be differentiated in three ways. First, prescriptive or injunctive norms can be distinguished from descriptive norms. Second, a distinction can be made between what is salient for all classmates or for a subgroup of norm setters, in particular popular peers. Third, social norms can be distinguished from perceived norms. The contributions to this special section invite debate on the future of research on norms, and suggest numerous avenues for further research, with hopes that an understanding of how social norms affect social development will better inform peer relations research as well as norm-based interventions.
Gait planning of a scale-driven snake-like robot for winding and obstacle crossing

Gait planning is an effective approach aiming at the difficulty in locomotion control of a multi-degree-of-freedom snake-like robot. In this article, a gait-generating method is presented with regard to the issue of its locomotion control in the process of winding–crossing variable-diameter cylindrical obstacles involving a P-R-joint scale-driven snake-like robot. The proposed method solves the problem of trajectory discontinuity of variable-diameter helix lines through linear fitting in the process of the obstacle crossing of the robot. The collision/interference between the robot and the obstacle is avoided by adding an extended helix segment to the front and rear ends of the obstacle. For direct linear fitting of the locomotion trajectory curve that will lead to velocity discontinuity, B-spline curves are used for smooth transition on generating the trajectory curve. A simulation experiment analysis is performed to demonstrate that the proposed gait-generating method can enable the snake-like robot to cross variable-diameter cylindrical obstacles.
Weak edge effects on trees in Bornean rainforest remnants bordering oil palm

Many tropical forests are dominated by edge habitat, with consequences for forest structure, carbon stocks, and biodiversity. However, edge effects are highly variable and context‐dependent, and are poorly quantified in oil palm landscapes. We studied edge effects in 10 lowland rainforest remnants bordering mature oil palm plantations on Borneo, by surveying 0.2 ha plots along transects running perpendicular to the forest edge (ten 1.6 km transects, 5‐6 plots per transect; 57 plots in total). We examined how edge proximity affected plot‐level forest structure (canopy cover, number and size of stems ≥10 cm diameter), aboveground carbon stocks, microclimate (air temperature and light intensity), and tree community composition and richness. The largest trees were significantly smaller (up to 21% reduced diameter) in plots near edges, and plot‐level carbon was up to 30% lower (model‐fitted average = 64.7 Mg ha−1 at 50 m from the edge, versus 92.3 Mg ha−1 at 1600 m), with the strongest effects within 300m of edges. However, these significant effects of edge proximity were relatively small in the context of existing variation, with distance‐from‐edge explaining <13% of the total variability in maximum tree size or carbon. In addition, there were generally no effects of edge proximity on any other component of forest structure, composition or diversity, and only a weak effect on microclimate. We conclude that limited edge effects in this system may reflect low structural contrast between forest and mature oil palm, and limited invasion of pioneer trees from plantations, which diminished edge influence in highly heterogeneous forest remnants.
Factors constraining the role of intermediaries in provisions of storage services for urban fresh fruits and vegetables supply chain in Dar es Salaam

Despite the critical role played by intermediaries in storage services of urban fresh fruits and vegetables, storage services of urban fresh fruits and vegetables in Dar es Salaam are still poorly provided by intermediaries. In this paper, we examine the factors constraining intermediaries in providing storage services in the sector. A qualitative case study was adopted and data were collected using documentary review, in-depth interviews, and Focus Group Discussion (FGD) and non-participant observations based on the purposive sample size of 73 respondents. Thematic data analysis strategy was adopted and data were analyzed using MAXQDA 20 software. Findings showed that the intermediaries are generally constrained by technological-related factors, the inadequacy of funds to invest in modern storage, limited knowledge and awareness of modern storage, excessive temperature and atmospheric conditions. We recommend that, in order to improve storage services installation of modern storage facilities in markets and collection centers, providing loans to intermediaries to buy modern packaging and packing facilities, improving market infrastructures, and training intermediaries on the importance of proper storage and how to use contemporary methodology could solve the problem at hand.