Miracle-dz/UniFAR-FTUs huggingface dataset:
Sub-tropical winter guests, offshore Portugal.

Coccolithophore communities developing off Portugal during November, 1996 were composed of species from both temperate (influenced by ENACWp) and subtropical (influenced by ENACWT) regions. The first group includes Gephyrocapsa mue//erae, G. ericsonii and Emiliania huxleyi. Members of the second group include (for 5m water-depth samples) Alisphaera spatula, Calcidiscus leptoporus, Coronosphaera mediterranea, Discosphaera rubifera, Gephyrocapsa ocecmica, Polycrater galapagensis. Rhabdosphaera clavigera, Syracosphaera pu/chra. S . molischii. Umbilicosphaera sibogae and Umbellosphaera tenuis, some of which are typical of subrropical upper photic zone water-masses. Deeper-water samples (between 75 and 85m water-depth) showed the presence of Algirosphaera quadricomu, Alveosphoera bimurara. Cyclolirlws anulus. Florisphaera profunda, Michaelsarsia elegans, Syracosphaera lamina and Turrilitlws latericioides; spec ies typica l of subtropical middle and lower photic zone water-masses. The presence of these subtropical assemblages during the end of summer autumn is taken as direct evidence that at least 120 to 220m of the uppermost part of the water-column is sourced from S of the Azores Front and fed into the Portuguese s lope poleward current system. Introduction The GuJf Stream system i s the dominant feature of N Atlantic surface circulation at present and probably has been since the closing up of the Isthmus of Panama at the end of the Early Pliocene. Deflected NE by the eastern N America coast, the tropical waters subdivide before crossing the Mid-Atlantic Ridge to form the N Atlantic Current, N of 46°N, and the less well-defined Azores Current, between 32° and 36°N (Pollard &Pu, 1985; Klein & Siedler, 19:89). The Azores Current thermohaline front occurs between 35° and 36°N, in close proximity to a deep chlorophyll maximum, and when it reaches the surface during winter it can tilt towards theN (Stramma & Muller, 1989). At Central Water depths, eastern N Atlantic waters of subtropical origin (ENACWT), formed along the Azores Front, were shown to occur off the Portuguese coast, over Lhe southward-flowing waters of s ubpolar origin (ENACWp) (Fiuza, 1984). At the surface, branches of the Azores Front can probably feed warmer and saltier waters into the fberian slope poleward-flowing current (the Portuguese Coastal Countercurrent PCC: Fiuza et al. , submitted), observed during the winter both by infrared satell ite pictures and in situ hydrograph.ic data (Frouin et al., 1990). Betwee n April and September (summer 4~~------~------~------~--------~------~----~~
Latest Developments in Minimally Invasive Spinal Treatment in Slovakia and Its Comparison with an Open Approach for the Treatment of Lumbar Degenerative Diseases

The study describes the benefits of MIS-TLIF (minimally invasive transforaminal lumbar interbody fusion) and compares them with OTLIF (open transforaminal lumbar interbody fusion). It compares blood loss, length of hospitalization stays (LOS), operation time, and return of the patient to the environment. A total of 250 adults (109 males and 141 females), mean age 59.5 ± 12.6, who underwent MIS-TLIF in the Neurosurgery Clinic (NSC) Ruzomberok, Slovakia, because of lumbar degenerative diseases (LDD), participated in this retrospective study. Data were obtained from the patients’ medical records and from the standardized Oswestry Disability Index (ODI) index questionnaire. To compare ODI in our study sample, we used the Student’s Paired Sample Test. To compare the MIS-TLIF and OTLIF approaches, a meta-analysis was conducted. Confidence intervals were 95% CI. The test of homogeneity (Chi-square (Q)) and the degree of heterogeneity (I2 test) among the included studies were used. Statistical analyses were two-sided (α = 0.05). All monitored parameters were significantly better in MIS-TLIF group: blood loss (p < 0.001), operation time (p < 0.001), and ODI changes (p < 0.001). LOS (p < 0.042) were close to the significance level. ODI in the study sample decreased by 33.44% points after MIS-TLIF, and it significantly increased as well (p < 0.001). The percentage of patients who were satisfied with the surgery they underwent was 84.8%. The study confirmed that the MIS-TLIF method is in general gentler for the patient and allows the faster regeneration of patient’s health status compared to OTLIF.
An adaptive edge-detection method based on histogram

In order to solve the problems of poor adaptability when setting threshold and the high probability of detecting pseudo-edges in the existing methods of edge detection, the paper proposes an adaptive edge-detection method based on histogram. Multi-scale wavelet transform is used to preprocess the image, the image details are highlighted obviously, and it also can avoid the effect of manual setting filter coefficients. Difference of gray values between the pixels of local area are used to calculate the gradients comprehensively, it extends the gradient direction to four directions. When calculating the gradient of edge pixel, the four directions make the expression of the gradients of edge points more perfect and avoid the edge points missing. The adaptive method is used to compute the threshold of edge-detection, the image is represented by histogram. Then use the ratio of the number of pixels in the bar and the total numbers of pixels to set the initial threshold. The regions on both sides of the initial threshold are used to calculate the high threshold and low threshold until the reasonable error between the current threshold and the previous threshold is very small iteratively. The acquired threshold makes the self-adaptability more reasonable and stronger, it also avoids the detection errors, the connection errors and the pseudo-edges which are caused by setting threshold artificially. The experimental results show that the proposed algorithm of edge detection has a good effect of preserving edge detail and filtering noise of image.
Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms

ABSTRACT Apigenin (4,’5,7-trihydroxyflavone) is one of the most studied flavonoids with low toxicity and abundantly present phenolic compound in the plant kingdom. The main sources of apigenin are fruits, vegetables, nuts, herbs, honey, and plant-based drinks like tea. Numerous plants produce apigenin as a secondary metabolite and its intake is strongly related to its anti-inflammatory propensities. The purpose of present review was to wade through the literature on the anti-inflammatory mechanisms of this metabolite in various diseases and summarize the key objectives as they appear. Existing literature reported that apigenin is a promising candidate in managing a panoply of inflammatory-related diseases including cancer, diabetes, obesity, depression, insomnia, infection, and respiratory, cardiovascular, hepatoprotective, neurodegenerative, and skin diseases. Studies showed that apigenin significantly decreases the secretion of various proinflammatory cytokines specifically tumor necrosis factor (TNF)-α, IL-1β, IL-6, and IL-10. Moreover, apigenin effectively blocks the nitric oxide-mediated cyclooxygenase-2 expression and monocyte attachment and Prostaglandin by lowering iNOS and COX-2 in both microglial and macrophage mouse cells. Apigenin can slow the course of nonalcoholic fatty liver disease (NAFLD) in vivo by reducing high fat diet (HFD)-induced deposition of lipids and oxidative stress. It also controlled redox imbalances, suppress neuronal death and showed memory enhancement/learning skills and a reduction of fibrillar amyloid deposits with lowered insoluble Aβ concentrations in vivo. Taken together, it can be argued that apigenin can wane inflammation and thus offers a promising future in slowing down the development of chronic diseases and associated complications.
Synthesis, Biological, Spectroscopic and Computational Investigations of Novel N-Acylhydrazone Derivatives of Pyrrolo[3,4-d]pyridazinone as Dual COX/LOX Inhibitors

Secure and efficient treatment of diverse pain and inflammatory disorders is continually challenging. Although NSAIDs and other painkillers are well-known and commonly available, they are sometimes insufficient and can cause dangerous adverse effects. As yet reported, derivatives of pyrrolo[3,4-d]pyridazinone are potent COX-2 inhibitors with a COX-2/COX-1 selectivity index better than meloxicam. Considering that N-acylhydrazone (NAH) moiety is a privileged structure occurring in many promising drug candidates, we decided to introduce this pharmacophore into new series of pyrrolo[3,4-d]pyridazinone derivatives. The current paper presents the synthesis and in vitro, spectroscopic, and in silico studies evaluating the biological and physicochemical properties of NAH derivatives of pyrrolo[3,4-d]pyridazinone. Novel compounds 5a-c–7a-c were received with high purity and good yields and did not show cytotoxicity in the MTT assay. Their COX-1, COX-2, and 15-LOX inhibitory activities were estimated using enzymatic tests and molecular docking studies. The title N-acylhydrazones appeared to be promising dual COX/LOX inhibitors. Moreover, spectroscopic and computational methods revealed that new compounds form stable complexes with the most abundant plasma proteins–AAG and HSA, but do not destabilize their secondary structure. Additionally, predicted pharmacokinetic and drug-likeness properties of investigated molecules suggest their potentially good membrane permeability and satisfactory bioavailability.
Using attributes of ungauged basins to improve regional regression equations for flood estimation: a deep learning approach

Abstract Regional quantile regression is used for estimating flood quantiles at ungauged sites. This study presents an application of stacked autoencoder (SAE), a deep learning algorithm, for developing regional quantile regression equation. Data from the conterminous United States are used for developing SAE-based regression equations and for comparing them against standard feed-forward neural networks. The deep learning algorithm improves the estimation of flood quantiles at 100 test sites (median mean square error (MSE) dropped by 10% and median coefficient of determination (R2) improved by 6%). The most impressive improvement is obtained when basin attributes of ungauged basins are used in SAE-based regression equations (median MSE dropped by 42% and median R2 improved by 19%). The results from the study show that information at ungauged basins, when employed in the deep learning framework, can significantly improve hydrological predictions.
Bevacizumab in recurrent WHO grades II–III glioma

Purpose The management of recurrent WHO grades II–III (rGII–III) glioma is not well established. This study describes the clinical outcomes in patients who received bevacizumab as rescue treatment. Methods In this retrospective study, the main inclusion criteria were as follows: adult patients with histologicaly proved rGII–III glioma according 2016 WHO classification treated with bevacizumab from 2011 to 2019, T1 contrast enhancement on MRI. Efficacy was assessed using the high-grade glioma 2017 Response Assessment in Neuro-Oncology criteria. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan–Meier method. Results Eighty-one patients were included (M/F ratio: 1.7, median age at diagnosis: 38 years) among whom 46 (56.8%) had an initial diagnosis of grade II glioma. Previous treatments included at least one surgical intervention, radiotherapy (98.8%), and ≥ 2 chemotherapy lines (64.2%). After bevacizumab initiation, partial response, stable disease, and progressive disease were observed in 27.2%, 22.2%, and 50.6% of patients. The median PFS and OS were 4.9 months (95% confidence interval [CI] 3.7–6.1) and 7.6 months (95% CI 5.5–9.9). Bevacizumab severe toxicity occurred in 12.3%. Twenty-four (29.6%) patients discontinued bevacizumab without radiological progression. Oligodendroglioma and age ≥ 38 years at diagnosis were more frequent in this subgroup (odds ratio = 0.24, 95% CI 0.07–0.84, p = 0.023 and 0.36, 95% CI 0.13–0.99, p = 0.042). Ten of these 24 patients were alive at 12 months and two patients at 8 years after bevacizumab initiation, without any subsequent treatment. Conclusion Bevacizumab can be an option for heavily pretreated patients with rGII–III glioma with contrast enhancement. In our study, bevacizumab displayed prolonged activity in a subgroup of patients.
Phytochemicals from Anneslea fragrans Wall. and Their Hepatoprotective and Anti-Inflammatory Activities

Anneslea fragrans Wall. , popularly known as “Pangpo tea”, is an edible, medicinal, and ornamental plant of the Family Theaceae. The leaves of A. fragrans were historically applied for the treatment of liver and intestinal inflammatory diseases in China. This study aimed to explore the hepatoprotective agents from A. fragrans leaves through hepatoprotective and anti-inflammatory assessment. The phytochemical investigation of the leaves of A. fragrans resulted in the isolation and identification of a total of 18 chemical compounds, including triterpenoids, aliphatic alcohol, dihydrochalcones, chalcones, flavanols, phenolic glycoside, and lignans. Compounds 1–2, 4–6, 11–12, and 16–18 were identified from A. fragrans for the first time. Compounds 7 and 14 could significantly alleviate hepatocellular damage by decreasing the contents of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and inhibit the hepatocellular apoptosis in the HepG2 cells induced by N-acetyl-p-aminophenol (APAP). In addition, compounds 7 and 14 inhibited reactive oxygen species (ROS) and malondialdehyde (MDA) contents and increased the catalase (CAT) superoxide dismutase (SOD), and glutathione (GSH) levels for suppressing APAP-induced oxidative stress. Additionally, compounds 7, 13, and 14 also had significant anti-inflammatory effects by inhibiting interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) productions on LPS-induced RAW246.7 cells.
Computational Fluid Dynamics Analysis in Biomimetics Applications: A Review from Aerospace Engineering Perspective

In many modern engineering fields, computational fluid dynamics (CFD) has been adopted as a methodology to solve complex problems. CFD is becoming a key component in developing updated designs and optimization through computational simulations, resulting in lower operating costs and enhanced efficiency. Even though the biomimetics application is complex in adapting nature to inspire new capabilities for exciting future technologies, the recent CFD in biomimetics is more accessible and practicable due to the availability of high-performance hardware and software with advances in computer sciences. Many simulations and experimental results have been used to study the analyses in biomimetics applications, particularly those related to aerospace engineering. There are numerous examples of biomimetic successes that involve making simple copies, such as the use of fins for swimming or the mastery of flying, which became possible only after the principles of aerodynamics were better understood. Therefore, this review discusses the essential methodology of CFD as a reliable tool for researchers in understanding the technology inspired by nature and an outlook for potential development through simulations. CFD plays a major role as decision support prior to undertaking a real commitment to execute any design inspired by nature and providing the direction to develop new capabilities of technologies.
EFFECT OF DIFFERENT PLANS OF NUTRITION ON GROWTH, FEED EFFICIENCY, BLOOD METABOLITES AND RELATIVE ECONOMICS IN SAHIWAL HEIFERS

This trial was designed with the objectives to select best and economical feedingstrategies to accelerate growth pattern for reducing age at maturity in buffalo heifers. Twenty Sahiwalheifers (Age = 24 ± 2-month and wt. = 200 ± 30 kg) were divided into four equal groups(n-5) on thebasis completely randomized design, Control group (D) of heifers was fed on green fodder only and noration was offered while test diets were comprised on TMR based on wheat straw (A), fodder(B) andsilage(C) with crude protein 10-11 percent. Feed intake of each experimental animal were recordeddaily. Animals were weighed at the start of experiment and fortnightly thereafter. Animals of group Cgained higher body weight (averaged 580 grams daily) comparing with other groups while animals ofgroup (D)fed on fodder only yielded very poorly growth. Dry Matter Intakes of all groups were similarand there was no effect of treatment of different plans of diet fed to animals. Dry matter, Crude proteinand crude fiber digestibility values were higher in animals fed total mixed ration based on corn silageand dry ration as compared to those fed other diets. Blood urea nitrogen values were higher in group Afed on TMR wheat straw based diet while blood glucose values were higher in animals of group B andC fed corn silage or green fodder based diet as indicator for availability of nutrients for growth.
Transversely Isotropic Hyperelastic Constitutive Model of Short Fiber Reinforced EPDM Based on Tensor Function

Short fiber reinforced EPDM is a new kind of composite material used in solid rocket motor winding and coating. It has relatively large deformation under the small stress condition, and the physical non-linear characteristic is obvious. Due to the addition of fiber in the specific direction of the rubber, the macroscopic mechanical properties are expressed as transversely isotropic properties. In order to describe the mechanical behavior under the impact and vibration, the transversely isotropic hyperelastic constitutive model based on tensor function is proposed. The symmetry of the transversely isotropic incompressible material limits the stress tensor ‘K’ to be characterized as a function of 5 tensor invariants and 4 scalar invariants. The third power constitutive equations of the model give 12 independent elastic constants of the transversely isotropic nonlinear elastic material. The experimental results show that the non-zero elastic constants are different in the fiber direction and at the different strain rate. Number and value of adiabatic layer and related products R & D has a reference value.
Management Of Innovative Basic Education Method For Job Creation In Rivers State

The study examined management of innovative basic education method for job creation in Rivers State. Two objectives and two research questions in line with two corresponding null hypotheses were formulated to guide the study. The theoretical framework was anchored on “Resource Based Theory of Entrepreneurship propounded by Barney in (1991). This study adopted a descriptive survey design with a population of the 278 junior public secondary schools across the 23 Local Government Areas in Rivers State. A stratified random sampling technique was used to draw a sample size of 125 principals from the population. A self-designed questionnaire titled: “Management of Innovative Basic Education Method for Job Creation Questionnaire (MIBEMJCQ)” was used for data collection. Scoring was done on a modified 4 point likert type scale of Strongly Agree (SA) = 4 points, Agree (A) = 3 points, Disagree (D) = 2 points and Strongly Disagree (SD) = 1 point. Test-retest technique was used to determine the reliability of the study. Reliability index of 0.69 was computed using Pearson Product Moment Correlation Coefficient which is high, reliable and adequate for the study. The mean and rank order were used in answering the research questions while z-test statistics was used in testing the hypotheses at 0.05 level of significance. The findings revealed amongst others that instructional supervision and team teaching are innovative basic education method for job creation in Rivers State. Based on the findings, the study therefore recommended amongst others that government and other stakeholders in education should through in-service training such as seminars, workshops and conferences enlighten school management on the need for instructional supervision in order to boost the quality of education and teaching staff.
Three-Dimensional-Printed Carbon Nanotube/Polylactic Acid Composite for Efficient Electromagnetic Interference Shielding

High-performance electromagnetic interference (EMI) shielding materials with ultralow density and environment-friendly properties are greatly demanded to address electromagnetic radiation pollution. Herein, carbon nanotube/polylactic acid (CNT/PLA) materials with different CNT contents, which exhibit characteristics of light weight, environmental protection and good chemical stability, are fabricated using 3D printing technology, where CNTs are evenly distributed and bind well with PLA. The performances of 3D-printed CNT/PLA composites are improved compared to pure 3D-printed PLA composites, which include mechanical properties, conductive behaviors and electromagnetic interference (EMI) shielding. The EMI shielding effectiveness (SE) of CNT/PLA composites could be improved when the content of CNTs increase. When it reaches 15 wt%, the EMI SE of 3D-printed CNT/PLA composites could get up to 47.1 dB, which shields 99.998% of electromagnetic energy. Meanwhile, the EMI shielding mechanism of 3D-printed CNT/PLA composites is mainly of absorption loss, and it generally accounts for more than 80% of the total shielding loss. These excellent comprehensive performances endow a 3D-printed CNT/PLA composite with great potential for use in industrial and aerospace areas.
Birational invariants : cohomology, algebraic cycles and Hodge theory cohomologie

In this thesis, we study some birational invariants of smooth projective varieties, in view of rationality questions for these varieties. It consists of three parts, that can be read independently.In the first chapter, we study, for some families of varieties, some stable birational invariants, that vanish for projective space and that appear naturally with Manin formulas. On one hand, we show for complex cubic 5-folds that the birational invariant given by the group of torsion codimension 3 cycles annihilated by the Deligne cycle map is controlled by the group of torsion 1-cycles of its variety of lines annihilated by the Deligne cycle map. We also prove that the Griffiths group of 1-cycles for the variety of lines of a hypersurface of the projective space over an algebraically closed field of characteristic 0, is trivial when the variety is smooth and Fano of index at least 3.The two last chapters focus on different aspects of the Chow-theoretic decomposition of the diagonal, a property which is invariant under stable birational equivalence, recently introduced by Voisin. In the second chapter, we adapt in characteristic greater than 2, part of the results, obtained by Voisin over the complex numbers, on the decomposition of the diagonal of cubic threefolds.In the last chapter, we study the concept of essential CH_0-dimension introduced by Voisin and related to the decomposition of the diagonal in that having essential CH_0-dimension 0 is equivalent to admitting a Chow-theoretic decomposition of the diagonal. We give sufficient (and necessary) conditions, for a complex variety with trivial group of 0-cycles, having essential CH_0-dimension non greater than 2 to admit a Chow-theoretic decomposition of the diagonal.
The Use of Creatine in Sport: An Educational Article

Many sports and strenuous exercises are associated with some degree of muscle damage, pain and fatigue that can lead to poor athletic progress, therefore the need for recovery speeding methods has been increasingly demanded. The use of performance enhancing nutritional supplements to improve athletic performance has been increasing during the previous decades. Supplementation with vitamins and minerals in excess of recommended daily allowances has been increasingly reported to have no effect on muscle mass or athletic performance, and the need to identify evidence-based sport supplements has been increasingly demanded. The aim of this paper is to provide an overview of the use of creatine in sport research progress.