Miracle-dz/UniFAR-FTUs huggingface dataset:
Business Psychology: Building an Interdisciplinary Bridge from the Ground Up

This paper describes the building of an innovative multi-disciplinary, outcomes-based, master’s degree program that integrates the fields of Business and Psychology. Historically, Business and Psychology have ranked among the top five majors chosen by undergraduate students. The program is theory-to-practice oriented and teaches the traditional disciplines of business including: economics, finance, marketing, human resources, strategy, and management from a human perspective. The Business Psychology program primarily emphasizes qualitative versus quantitative-oriented teaching methods. Students of the program analyze individual, group, and organizational level business issues through the application of both traditional and new brain-based tools. Individual and professional developments are also hallmarks of the 14 month program. Additionally, the program incorporates some of the latest findings in neuroscience as they relate to the individual business disciplines. The paper will be presented from three viewpoints; those of the developer and program chair, a participating student, and an adjunct professor teaching in the program. Beginning with a rationale for program development, the paper will proceed through research into potential competitive programs, considerations in the initial design of courses, inclusion of imbedded assessment, the selection of teaching faculty, a description of the internal and external steps that led to its approval by state and regional accrediting bodies, problems in initial delivery, and the program’s incorporation into the sponsoring university’s learning management system. Current status as well as initial student and faculty reactions will be presented along with complicating factors relating to its delivery in both face-to-face and online formats. The paper will conclude with lessons learned from this point in its early history.
Efficient description of impedance and radiation features in printed-circuit leaky-wave structures-an unconventional scattering-matrix approach

This paper presents an original circuit model that furnishes an efficient description of the impedance and of the radiation performance for typical printed-circuit leaky-wave structures. In particular, referring to a junction between slot-coupled feeding and radiating microstrips, we have developed an unconventional equivalent transmission-line formulation, involving the propagation of the dominant mode for the feeding line and of the first higher mode for the radiating line, which is leaky. The quantification of the relevant scattering matrix, achieved with spectral-domain techniques, suitably summarizes the coupling effects and, consequently, the radiative features. Various antenna configurations have been tested, and the relevant results have been validated through comparisons with heavier full-wave numerical approaches. In addition to substantial computational advantages, this innovative approach gives the possibility of treating printed leaky-wave structures in a convenient fashion by means of a network formalism similar to that used in standard microwave circuits.
FaLC Transport Simulation Module: How accurate can simplified travel time calculations be?

This paper presents, the assumptions, simplifications and accuracy of different approaches to estimate travel times in transport simulation. Additionally, the paper focuses on the assumptions in the simplified transport simulation module in FaLC as well as its methodology to achieve efficient results. To validate different approaches, the paper compares two different results for travel time estimations (calculation based on speed regression or maximum allowed speed) with the results of the Swiss National Passenger Transport Model (NPVM) calculated in VISEM.
Classification of bladder cancer cell lines according to regulon activity

Bladder cancer is one of the most frequent cancers and causes more than 150.000 deaths each year. During the last decade, several studies provided important aspects about genomic characterization, consensus subgroup definition, and transcriptional regulation of bladder cancer. Still, much more research needs to be done to characterize molecular signatures of this cancer in depth. At this point, the use of bladder cancer cell lines is quite useful for the identification and test of new signatures. In this study, we classified the bladder cancer cell lines according to the activities of regulons implicated in the regulation of primary bladder tumors. Our regulon gene expression-based classification revealed three groups, neuronal-basal (NB), luminal-papillary (LP), and basal-squamous (BS). These regulon gene expression-based classifications showed a quite good concordance with the consensus subgroups assigned by the primary bladder cancer classifier. Importantly, we identified FGFR1 regulon to be involved in the characterization of the NB group, where neuroendocrine signature genes were significantly upregulated, and further β-catenin was shown to have significantly higher nuclear localization. LP groups were mainly driven by the regulons ERBB2, FOXA1, GATA3, and PPARG, and they showed upregulation of the genes involved in epithelial differentiation and urogenital development, while the activity of EGFR, FOXM1, STAT3, and HIF1A was implicated for the regulation of BS group. Collectively, our results and classifications may serve as an important guide for the selection and use of bladder cancer cell lines for experimental strategies, which aim to manipulate regulons critical for bladder cancer development.
Wohlfahrtiimonas chitiniclastica Monomicrobial Bacteremia in a Homeless Man

We report a case of septic shock attributable to monomicrobial bloodstream infection secondary to Wohlfahrtiimonas chitiniclastica infection. This case suggests that W. chitiniclastica likely possesses the virulence to cause severe disease. Culture-independent techniques were essential in the identification of this organism, which enabled selection of appropriate therapy.
Binary flower pollination algorithm based user scheduling for multiuser MIMO systems

: In this article, a multiuser (MU) multiinput multioutput (MIMO) system is considered, which is essential to support a huge number of subscribers without consuming extra bandwidth or power. Dirty paper coding (DPC) for MU MIMO channel achieves the peak sum-rate for the MU multiple antenna system at the cost of high computational complexity. Both user and antenna scheduling with a population based meta-heuristic algorithm, i.e. binary flower pollination algorithm (binary FPA) has been demonstrated in this article to achieve system sum-rate comparable to DPC with very less computational complexity and time complexity. Moreover, binary FPA shows a significant improvement in system throughput/sum-rate performance as compared to other population based meta-heuristic algorithms like binary bat algorithm (binary BA) and binary genetic algorithm (binary GA). Furthermore, the proposed binary FPA algorithm successfully achieves higher system sum-rate as compared to random search scheme and different existing suboptimal scheduling algorithms from literature as well. The binary FPA has also better convergence rate and searching ability than both binary BA and binary GA techniques. The percentage deviation achieved by the proposed binary FPA algorithm is quite less than that of binary BA, binary GA, random search method, and existing suboptimal scheduling algorithms from the literature. The eﬀiciency of binary FPA in all these fronts is verified using exhaustive simulation studies.
Data Privacy: Are We Accidentally Sharing Too Much Information?

We are living in a world in which we are surrounded by technology. With the conveniences of technology also come nuisances. People are exposing personally identifiable information (PII) about themselves without realizing the consequences of this action. Many users of social network sites are aware of the possible pitfalls of failing to secure their personally identifiable information using the privacy settings of the site. However, what about the personally identifiable information placed in the photos that individuals place online? What about accidentally sharing information by clicking “reply all” to an email that was meant for only one recipient or attaching the wrong document in an email? With the increased deployment of electronic devices that connect us around the world, we often unintentionally share personal information with those we do not know or whom we did not intend to disclose the private details. The oversharing of information, how it is collected, and who collects it can be a source of power. As users of these communication channels, we need to be aware of how information can be accidentally shared with those we did not intend and the negative effects it can have on the user. To the best of the researcher’s knowledge, this is the first attempt to measure accidental sharing of information via mobile devices, email, public Wi-Fi and text messaging. This 2013 exploratory study investigates how students at a mid-Atlantic University willingly and unwillingly share personal information and the potential effect this sharing has on their digital lives.
Effect of Pursed-Lip Breathing using a Windmill Toy Model on Breathing Efficiency in Chronic Obstructive Pulmonary Disease Patients

Chronic obstructive pulmonary disease (COPD) is the third-highest cause of death in the world, also true in Thailand. There are various methods to treat COPD such as medication and non-drug therapies for respiratory rehabilitation. The aim of this study is to investigate the effectiveness of pursed-lip breathing (PLB) by using a windmill toy in COPD patients. The participants in this randomized controlled trial study were 60 to 75 years old. The total number of 46 participants were equally divided into 2 groups: The intervention group and the control group (23 participants each). The intervention group used breathing training through a windmill toy, whereas the control group received training in standard breathing patterns. The training was performed over sessions in 1 week. Lung function, respiratory muscle strength, and 6-minute walk test (6MWT) were recorded at baseline, and between 6 - 12 weeks (follow-up). The intervention group and the control group improved significantly in lung function and muscle strength (p < 0.05). In addition, 6MWT in the intervention group increased significantly when compared to the control group (p < 0.05) at week 12. In conclusion, the PLB using a windmill toy is a new form of breathing training that is effective in promoting the strength of the muscles used for breathing, lung performance, and cardiovascular function in COPD patients. HIGHLIGHTS The use of windmill toys is a new form of breathing exercise that is effective in strengthening Using innovative models applied in medicine and public health to promote prevention of severe disease The greatest benefit of pulmonary function training is that patients have a better quality of life and longer life
Re‐evaluating the actin‐dependence of spectraplakin functions during axon growth and maintenance

Axons are the long and slender processes of neurons constituting the biological cables that wire the nervous system. The growth and maintenance of axons require bundles of microtubules that extend through their entire length. Understanding microtubule regulation is therefore an essential aspect of axon biology. Key regulators of neuronal microtubules are the spectraplakins, a well-conserved family of cytoskeletal cross-linkers that underlie neuropathies in mouse and humans. Spectraplakin deficiency in mouse or Drosophila causes severe decay of microtubule bundles and axon growth inhibition. The underlying mechanisms are best understood for Drosophila Short stop (Shot) and believed to involve cytoskeletal cross-linkage: the N-terminal calponin homology (CH) domains bind to F-actin, and the C-terminus to microtubules and Eb1. Here we have gained new understanding by showing that the F-actin interaction must be finely balanced: altering the properties of F-actin networks or deleting/exchanging Shot’s CH domains induces changes in Shot function - with a Lifeact-containing Shot variant causing remarkable remodelling of neuronal microtubules. In addition to actin-MT cross-linkage, we find strong indications that Shot executes redundant MT bundle-promoting roles that are F-actin-independent. We argue that these likely involve the neuronal Shot-PH isoform, which is characterised by a large, unexplored central plakin repeat region (PRR). Work on PRRs might therefore pave the way towards important new mechanisms of axon biology and architecture that might similarly apply to central PRRs in mammalian spectraplakins.
Assessing the Biological Effects of Anthropagenic Contaminants In Situ

This paper presents a monitoring strategy for assessing the effects of anthropogenic contaminants on aquatic organisms. This strategy takes advantage of our increased understanding of the mechanisms which underlie stress metabolism as a basis for assessing stress in native organisms in situ. General stress responses which react to a wide range of environmental factors are used to initially screen for deleterious biological effects due to contaminants. If data from this screening indicates that organisms are stressed, stressor-specific responses which are elicited by contaminants or classes of contaminants would be measured to identify the causative factors. These data allow us to determine both the extent of biological stress in native organisms in situ and identify the environmental factors responsible for the observed effects.
Numerical Investigation of the Flow in a Radial Vaned Diffuser Without and With Aspiration

An analysis of the flow in a centrifugal compressor vaned diffuser from the nominal operating point of the compressor stage to a point near surge was conducted. Study of performance coefficients, and then of the skin-friction pattern, reveals the growth of a corner stall between the hub wall and the suction side of the vane when moving the operating point towards surge.Considering the location of the skin-friction pattern singular elements, a boundary layer suction technique has been developed and then numerically tested. The hub wall corner stall was controlled, and performances predicted near surge have been significantly modified, as well as the flow structures when reaching the limit of numerical stable operating range: the major change in the topology of the flow occurs now within the impeller, in the splitter leading edge region, and let think about a leading role of the main blade tip clearance vortex in the instabilities release. The surge massflow seems to have been significantly reduced.Copyright © 2012 by ASME
Surgical Implant Generation Network (SIGN) Solid Intramedullary Interlocking Nail in the Lower Extremity: An Observational Study from Western Nepal

Key Wor ds: SIGN , tibia, femoral, Nepal ABSTRACT Background: Intra-medullary nail fixation has become the standard of treatment for both femoral and tibial shaft fractures. It functions as internal splints that allow secondary fracture healing. The axial and rotational stability of the conventional hollow interlocking nails depends primarily on the locking screws. Surgical Implant Generation Network (SIGN) was formed in 1999, with the vision of creating an equality of fracture care throughout the world. This system has been utilized at a variety of facilities in low income countries throughout the world. Objective: To evaluate the efficacy of SIGN nailing in the long bones of the lower extremity. Method and Materials: This was a hospital based, retrospective study which was conducted in the Orthopaedics Department of the Manipal College of Medical Sciences, Pokhara, Nepal between May, 2010 and August, 2011. A total of 24 cases with fractures of the femur and the tibia were studied. Both closed and open types of fractures were included and the fracture fixation was done by using SIGN interlocking solid nails and instrumentation. The analysis was done by using descriptive statistics and the testing of the hypothesis. The data was analyzed by using Excel 2003, the Statistical Package for the Social Sciences (SPSS) for Windows Version 16.0 (SPSS Inc; Chicago, IL, USA) and the EPI Info 3.5. 1 Windows Version. Results: Out of the 24 patients, 16 (66.7%) were males and 8 (33.3%) were females. The average age of the patients was 29.58, with a range of 13-60 years. An intra-medullary interlocking SIGN nail was performed in 18 (75%) tibial and 6 (25 %) femoral fractures, with 41.7 % being right sided and 58.3% being left sided. The types of fractures which were included were closed= 66.67 % and open fractures= 33.33%. According to the Gustilo-Anderson classification, 4.17 % were Gustilo I, 25 % were Gustilo II and 4.17 % were Gustilo III a. Open reduction was done in 58.3 % and closed reduction was done in 41.7 % of the cases. Reaming was done in all the cases and no post-operative infections were noted. There was a significant relationship between the type of fracture and factors like the affected side, the method of the fracture reduction and the location of the fracture. Conclusion: The SIGN solid intramedullary interlocking nail shows promising results in comparison to the hollow nail because of its better strength, better accuracy in distal locking and surprisingly better results in infection and non-union
Model-based software component testing

Software component testing (SCT) is a proven software engineering approach to evaluating, improving and demonstrating component reliability and quality for producing trusted software components, which is critical to support the success of component-based software engineering. Model-based testing (MBT) of software components enables the utilisation of a consistent model-based approach and specification (e.g. UML models) for effective component development and testing. However, advancing from model-based development to MBT poses certain crucial challenging problems that remain unresolved and hamper the utilisation of SCT/MBT, and further research is thus required to address those problems to achieve the goal of desirable SCT/MBT effectiveness. This thesis has comprehensively reviewed the important concepts, principles, characteristics and techniques of SCT/MBT in the literature to provide a solid foundation for this research and introduced a set of useful new concepts and definitions to form the first major part of the thesis’s original contributions as follows: 1. In the research areas of software components and software component testing: (a) A new comprehensive taxonomy of software component characteristics (b) A new software component definition (c) A new definition of software component testing (d) A useful taxonomy of software component testing techniques (e) A practical taxonomy of component testability improvement approaches 2. In the research areas of model-based testing and UML-based testing: (a) A study of model-based tests (b) A new definition of model-based testing (c) A new test model definition (d) A new definition of UML-based testing (e) A core UML subset for SCT (f) A study and review of use case driven testing and scenario-based testing The principal original contribution of this thesis is to introduce a novel hybrid SCT methodology, called Model-Based Software Component Testing (MBSCT), which consists of five major methodological components, a three-phase testing framework, six main methodological features and six core testing capabilities. In more detail: (1) The Model-Based Integrated SCT process incorporates software component
A novel mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein fibrils and recapitulates its pathological diversity

A novel mutation (E83Q), the first in the NAC domain of alpha-synuclein (aSyn), was recently identified in a patient with dementia with Lewy bodies. We investigated the effects of this mutation on the aggregation of aSyn monomers and the structure, morphology, dynamic, and seeding activity of the aSyn fibrils in neurons. We found that it dramatically accelerates aSyn fibrillization and results in the formation of fibrils with distinct structural and dynamic properties. In cells, this mutation is associated with higher levels of aSyn, accumulation of pS129, and increased toxicity. In a neuronal seeding model of Lewy bodies (LB) formation, the E83Q mutation significantly enhances the internalization of fibrils into neurons, induce higher seeding activity and results in the formation of diverse aSyn pathologies, including the formation of LB-like inclusions that recapitulate the immunohistochemical and morphological features of brainstem LBs observed in PD patient brains. Teaser A novel mutation (E83Q) exacerbates alpha-synuclein aggregation and toxicity and reproduces PD pathological diversity.
Self-Perceived Stress Is Associated With Chest Pain and Personality in Patients With Refractory Functional Gastrointestinal Disorders

Supplemental digital content is available in the text. Abstract Stressful events are frequently associated with functional gastrointestinal disorders (FGID). This study aims to determine if the severity of self-perceived stress is associated with specific FGID and personality characteristics in 822 patients with FGID who have filled a Rome III questionnaire, Minnesota Multiphasic Personality Inventory 2 (MMPI-2), and a 10-point Likert scale for self-perceived stress. According to stress severity, the patients were divided into three groups: low (<4; n = 183), moderate (4–6; n = 283), and severe stress (>6; n = 356). Female sex was more frequent in the severe stress group than in the low stress group (p = 0.001). Stress severity was strongly correlated with the two MMPI-2 posttraumatic stress scales. Clinically, chest pain was more frequently reported by severe stress patients than moderate stress patients. MMPI-2 clinical scales vary significantly according to the severity of stress, and “mild stress” patients have increased hysteria and depression scales and showed a higher frequency of irritable bowel syndrome–diarrhea. This study shows that severe stress severity is associated with a higher frequency of noncardiac chest pain and correlated with most personality items.
Benchmarking the performance of homogenization algorithms on synthetic daily temperature data

This paper describes a new homogenization algorithm validation methodology, and its use to assess the skill of eight different algorithms, when applied to synthetic daily temperature time series. These algorithms were ACMANT, Climatol (in both daily and monthly configurations), DAP, HOM, MAC‐D, MASH and SpliDHOM. Algorithms were tested on benchmark data replicating daily temperature variability in four regions in North America: Wyoming, the South East, the North East and the South West. These benchmarks contained plausible spatial and temporal correlation, differing station densities and both abrupt and gradual inhomogeneities. Algorithm ability was assessed both according to detection of inhomogeneities and correction of their effects, investigating bias, root‐mean‐square error (RMSE), linear trend recovery, station extremes and variability recovery. Inhomogeneities with a magnitude greater than 1°C were those most commonly detected with smaller inhomogeneities, and those that were not constant over time, proving harder to identify. Regional RMSE was always reduced by all algorithms and regional bias was reduced in over half of the region/scenario pairs. Trend recovery was variable, but the correct sign of regional trends was retained by all algorithms. Areas for future algorithm improvement include working with autocorrelated data and correcting moments higher than the mean. The data are available from https://www.metoffice. gov.uk/hadobs/benchmarks and the validation code from https://github.com/RachelKillick/Daily_benchmarks allowing the extension of this work and its application to new algorithms.