Miracle-dz/UniFAR-FTUs huggingface dataset:
Extruded Fracture Dislocation of Talus, A Rare and Devastating Injury. A Series of Five Cases

Introduction: Extrusion of the talus with fracture dislocation is a very rare and devastating ankle injury usually caused by high-energy impact. There is no common consensus on the management for this type of injury. We intend to report on our experiences with its management and outcomes. Case Report: We received a total of five cases of extruded fracture dislocation of the talus between March 2016 and April 2020. All fracture talus was Hawkins Type IV fracture. All five patients were male with an age range between 18 and 54 years and have sustained an injury in road traffic accidents. They were managed with wound debridement, talar preservation open reduction, and internal fixation with an application of an external fixator for wound care. All were followed up for 2 years. Conclusion: Extruded fracture dislocation of the talus is a rare and devastating ankle injury. Its management is time-dependent and involves meticulous planning for a favorable outcome.
THE ETHANOL EXTRACT OF JUKUT PENDUL (KYLLINGA NEMORALIS) EXHIBITS INHIBITORY ACTIVITY AGAINST THE GROWTH OF STAPHYLOCOCCUS AUREUS

Staphylococcus aureus is a pathogenic bacteria that is often found to have resistance to antibiotics. Jukut pendul (Kyllinga nemoralis) extract is known to have antibacterial compounds such as flavonoids, tannins, saponins, and steroids. The purpose of this study was to determine the inhibitory ability of jukut pendul ethanol extract against Staphylococcus aureus bacteria. This research used the Kirby-Bauer disc diffusion method with five treatments within five repetitions. Data analysis was carried out using One Way Anova variance analysis. The variation in extract concentration tested was 5, 10, 20, and 40% with 96% ethanol as the control group and Ciprofloxacin as the work control. The results showed that extract concentrations of 5, 10, 20, and 40% were able to inhibit Staphylococcus aureus bacteria with an average inhibitory zone of 9,36; 10,85; 11,64; and 12.15 mm, respectively. The inhibitory zone formed indicates that jukut pendul ethanol extract has moderate to strong inhibitory ability in inhibiting the growth of Staphylococcus aureus bacteria.
Metabolic Signature of Warburg Effect in Cancer: An Effective and Obligatory Interplay between Nutrient Transporters and Catabolic/Anabolic Pathways to Promote Tumor Growth

Simple Summary Cancer represents unrestricted growth with the removal of conventional brakes that control growth under normal conditions. This requires novel mechanisms to provide metabolic energy to fuel the rapid growth and also macromolecules to support cell renewal. This unique need in cancer cells is accomplished by an efficient interplay between selective nutrient transporters and the reprogramming of cellular metabolism that modifies specific catabolic and anabolic pathways. These modified biochemical pathways generate certain metabolites that are seen at high levels only in cancer cells, and reroute signaling cascades, alter gene expression profiles, and exert biological effects in support of the growth and proliferation of cancer cells. A clear understanding of the metabolic signature that is unique to cancer cells is necessary not only to appreciate how the unrestricted growth is accomplished in cancer but also to exploit these cancer-cell-specific nutrient transporters and metabolic pathways as drug targets to develop new anticancer therapeutics. Abstract Aerobic glycolysis in cancer cells, originally observed by Warburg 100 years ago, which involves the production of lactate as the end product of glucose breakdown even in the presence of adequate oxygen, is the foundation for the current interest in the cancer-cell-specific reprograming of metabolic pathways. The renewed interest in cancer cell metabolism has now gone well beyond the original Warburg effect related to glycolysis to other metabolic pathways that include amino acid metabolism, one-carbon metabolism, the pentose phosphate pathway, nucleotide synthesis, antioxidant machinery, etc. Since glucose and amino acids constitute the primary nutrients that fuel the altered metabolic pathways in cancer cells, the transporters that mediate the transfer of these nutrients and their metabolites not only across the plasma membrane but also across the mitochondrial and lysosomal membranes have become an integral component of the expansion of the Warburg effect. In this review, we focus on the interplay between these transporters and metabolic pathways that facilitates metabolic reprogramming, which has become a hallmark of cancer cells. The beneficial outcome of this recent understanding of the unique metabolic signature surrounding the Warburg effect is the identification of novel drug targets for the development of a new generation of therapeutics to treat cancer.
Theory of ∆ conditional randomized truth degree in Gödel n-valued propositional logic system of adding ∆ operator

: In this paper, ∆ conditional randomized truth degree of propositional formula is put forward in Gödel n -valued propositional logic system. It adds ∆ operator compared with conditional randomized truth degree. On this basis, some inference rules such as MP, HS, intersection inference, union inference and their related properties are studied. At last, the concepts of ∆ conditional randomized similarity degree, ∆ conditional randomized pseudo-metric between propositional formulas are given, and their related good properties are discussed
Annexin A7 mediates lysosome repair independently of ESCRT-III

Lysosomes are crucial organelles essential for various cellular processes, and any damage to them can severely compromise cell viability. This study uncovers a previously unrecognized function of the calcium- and phospholipid-binding protein Annexin A7 in lysosome repair, which operates independently of the Endosomal Sorting Complex Required for Transport (ESCRT) machinery. Our research reveals that Annexin A7 plays a role in repairing damaged lysosomes, different from its role in repairing the plasma membrane, where it facilitates repair through the recruitment of ESCRT-III components. Notably, our findings strongly suggest that Annexin A7, like the ESCRT machinery, is dispensable for membrane contact site formation within the newly discovered phosphoinositide-initiated membrane tethering and lipid transport (PITT) pathway. Instead, we speculate that Annexin A7 is recruited to damaged lysosomes and promotes repair through its membrane curvature and cross-linking capabilities. Our findings provide new insights into the diverse mechanisms underlying lysosomal membrane repair and highlight the multifunctional role of Annexin A7 in membrane repair.
Peran Perawat dalam Mengatasi Diabetes Distress

This research aims to guide nurses in therapeutic communication with patients with diabetes distress. The method used in this writing is a literature review through several databases, namely Pubmed, ClinicalKey, Proquest, and Science Direct. The research results show that diabetes distress is a common thing experienced by patients with diabetes mellitus. In conclusion, treating diabetes distress is part of comprehensive diabetes management. Keywords: Diabetes Distress, Nurse's Role
Optimization and experimental validation of the air intake holes of the lithium-ion battery pack

Energy storage systems enable the storage of energy and provide access to carbon-neutral, environmentally friendly energy whenever or wherever it is needed. Lithium-ion batteries are currently the most preferred type among various battery technologies and are widely used in energy storage systems. Some of the features that make lithium-ion batteries advantageous include high energy density, long life, low maintenance requirements, and high operating voltage. The growing demand for energy throughout the day increases the need for batteries with high storage capacity. However, the increased capacity also leads to heating issues in lithium-ion batteries. The heating problem in lithium-ion batteries can result in nonhomogeneous temperature distribution, shortened lifespan, thermal runaway, increased internal resistance, and performance loss. Therefore, an effective thermal management system is essential for cooling lithium-ion batteries. This study aims to provide insight into the forced air cooling of prismatic 280 Ah LiFePo4 batteries, which have limited information in the literature and are more prone to overheating compared to lower-capacity batteries. In this study, five different battery pack case designs, each with different sizes and numbers of air intake holes, were determined and modelled using the SolidWorks program. Within the battery pack cases, 16 280 Ah lithium-ion batteries are placed, and an axial fan is used to cool these batteries. Initially, computational fluid dynamics analyses of the five different designs were performed in the SolidWorks Flow Simulation program. An experiment was then conducted on the design that provided the most efficient thermal management to validate the numerical results. The selected design, fulfilling the purpose of homogeneous temperature distribution and having the minimum temperature difference between batteries, was designated as Design 5. It exhibited a 62 % improvement in cooling performance with a 0.25 °C temperature difference, indicating successful temperature homogeneity between batteries. During a two-hour experiment with a 140 A discharge current, temperature measurements were taken from the surfaces of the batteries using thermocouples. Finally, the maximum error rate between experimental and numerical studies was determined to be 1.47 %, indicating successful validation of the numerical study. The air intake hole optimization, a novel design approach, prevents temperature distribution inhomogeneity caused by the distance of the batteries to the fan and offers an effective way to cool down high-capacity 280 Ah batteries.
Variant Scape: um jogo para exercitar conceitos de introdução à lógica de programação

Aprender a programar é algo complexo, que exige alto grau de abstração, o que se comprova pelas altas taxas de reprovação e evasão nos cursos de Computação. Este artigo apresenta “Variant Scape”, um jogo que tem por objetivo promover o desenvolvimento da lógica de programação e do Pensamento Computacional. O jogo utiliza da abstração das regras da programação em sua mecânica em que o jogador deve utilizar variáveis, estruturas condicionais e de repetição, além de propor atividades com as operações de Matemática básica (soma, subtração, multiplicação e divisão) durante a gameplay. Resultados preliminares mostraram que o jogo teve uma boa aceitação em questões como design e gameplay, porém foi levantada a necessidade de ajustes em feedbacks através da adição de elementos na interface do jogo.
Investigating the role of Emotions on the learning effectiveness in VR enabled teaching interventions in school

Technology advancements are known to frequently have direct and significant effects on the educational sector. There is an increasing trend in the academic use of Virtual Reality to demonstrates usability, utility, and amusement of the learner. The use of technological tools like virtual reality (VR) helps people develop the digital-age literacy, creative thinking, communication, teamwork, and problem-solving abilities that are required to transform information rather than merely consume it. VR improves standard courses to accommodate students' various learning demands. Applications for skill mastery and training are now possible because to recent advancements in digital reality generation. The learning is made more enjoyable and productive for the user by using real like photos, videos, animations etc., which provide augmented knowledge about the surroundings. Learners commitment is a significant predictor of attainment, retention and diligence for enhanced learning. The research papers findings reported that the VR environment increases the learning outcomes and offer many benefits for devoting time and money to them in higher and tertiary educational settings. For current research 347 students had been assigned to VR technology for learning. The outcome of this research supports the objective that the emotions affect learning using the VR technologies. The results revealed that the positive emotions affect the Ergonomic, Learning, Hedonic and overall learning. Emotions influence students' desire to study, based on their eagerness, inquisitiveness and willingness to accomplishing their goals of positive outcomes. Emotions make the implementation of learning approaches easier. Additionally, emotions can influence self-control techniques.
Alcohol use and the pain system

The World Health Organization’s epidemiological data from 2016 revealed that while 57% of the global population aged 15 years or older had abstained from drinking alcohol in the previous year, more than half of the population in the Americas, Europe, and Western Pacific consumed alcohol. The spectrum of alcohol use behavior is broad: low-risk use (sensible and in moderation), at-risk use (e.g., binge drinking), harmful use (misuse) and dependence (alcoholism; addiction; alcohol use disorder). The at-risk use and misuse of alcohol is associated with the transition to dependence, as well as many damaging health outcomes and preventable causes of premature death. Recent conceptualizations of alcohol dependence posit that the subjective experience of pain may be a significant contributing factor in the transition across the spectrum of alcohol use behavior. This narrative review summarizes the effects of alcohol at all levels of the pain system. The pain system includes nociceptors as sensory indicators of potentially dangerous stimuli and tissue damage (nociception), spinal circuits mediating defensive reflexes, and most importantly, the supraspinal circuits mediating nocifensive behaviors and the perception of pain. Although the functional importance of pain is to protect from injury and further or future damage, chronic pain may emerge despite the recovery from, and absence of, biological damage (i.e., in the absence of nociception). Like other biological perceptual systems, pain is a construction contingent on sensory information and a history of individual experiences (i.e., learning and memory). Neuroadaptations and brain plasticity underlying learning and memory and other basic physiological functions can also result in pathological conditions such as chronic pain and addiction. Moreover, the negative affective/emotional aspect of pain perception provides embodied and motivational components that may play a substantial role in the transition from alcohol use to dependence.
Copper requirements and acquisition mechanisms in marine phytoplankton

ii Preface. iii Table of
SEGREGASI ETNO-RELIGIUS: Upaya Resolusi Konflik dan Pembangunan Perdamaian

Ethno-religious segregation in Lombok, especially in Mataram existed because of population migration and the implication of the implemenation of the policy on the politic of Karang Asem Hinduism Mataram Kingdom that dominated this area for more than one century (1670-1820). The policy subjected to the community made the fixed social stratification in the context of community settlement, and generated two different groups, the Balinesse-Hiduism as the noble and Sasak-Muslim as the lower-level society members. Applying qualitative method and conflict study approach it was revealed that historical legacy had been become the socialpsychological barrier for the two communities for making open and trustful interaction. *** Segregasi etno-religius di wilayah Lombok, khususnya di Mataram selain terjadi karena migrasi penduduk, juga merupakan implikasi dari penerapan kebijakan politik kerajaan Hindu Karangasem Mataram yang menguasai wilayah ini selama 1,5 abad, yaitu dari tahun (1670-1820 M). Kebijakan itu antara lain dalam bentuk mempertahankan stratifikasi sosial masyarakat dalam pemukiman, sehingga melahirkan komunitas Bali-Hindu sebagai kelompok bangsawan dan komunitas Sasak-Islam sebagai kelompok rakyat kelas bawah. Melalui metode kualitatif dan pendekatan kajian konflik tampak bahwa warisan sejarah telah menjadi hambatan psikologis-sosial kedua komunitas untuk berinteraksi secara terbuka dan saling mempercayai.
Recomendação Híbrida de Objetos de Aprendizagem a partir da Predição de Necessidades Personalizadas de Estudantes

Dada a grande quantidade de dados disponíveis, está cada vez mais difícil identificar objetos de aprendizagem (OA) que contribuirão no processo de aprendizagem dos estudantes. Neste cenário, este trabalho propõe um framework de modelo híbrido para recomendação de OA com base nas preferências e nas necessidades de cada estudante. Para isso, o framework realiza um processo de predição de desempenho para identificar eventuais dificuldades que um estudante poderá apresentar e o framework gera recomendações assertivas, aumentando as chances de aprovação, tendo em vista que o mesmo contará com uma gama de OA que permitirão um melhor desempenho dentro de um semestre letivo.
Stochastic Modeling of Wind Derivatives with Application to the Alberta Energy Market

Wind-power generators around the world face two risks, one due to changes in wind intensity impacting energy production, and the second due to changes in electricity retail prices. To hedge these risks simultaneously, the quanto option is an ideal financial tool. The natural logarithm of electricity prices of the study will be modeled with a variance gamma (VG) and normal inverse Gaussian (NIG) processes, while wind speed and power series will be modeled with an Ornstein–Uhlenbeck (OU) process. Since the risk from changing wind-power production and spot prices is highly correlated, we must model this correlation as well. This is reproduced by replacing the small jumps of the Lévy process with a Brownian component and correlating it with wind power and speed OU processes. Then, we will study the income of the wind-energy company from a stochastic point of view, and finally, we will price the quanto option of the European style for the wind-energy producer. We will compare quanto option prices obtained from the VG process and NIG process. The novelty brought into this study is the use of a new dataset in a new geographic location and a new Lévy process, VG, apart from NIG.
Water, Power and Identity: The Cultural Politics of Water in the Andes

1. Introduction: Water Control Battlefields 2. Water Rights in Collectively Managed Andean Systems 3. Regimes of Waters Truth: Interdisciplinarity, Domains of Water Control and Hydro-social Cycle Politics 4. Embeddedness of Water Control in the Andean Peasant Economy 5. The Hydro-Politics of Identity: Coercive and Capillary Powers 6. Panoptic Power and the Moralization of Water Control Technology 7. Expertocratizing Local Water Rights 8. Neoliberalizing Collective Water Rights and Spaces of Resistance 9. Resistance as 'Con-fusion': Mimesis, Mimicry and Contesting the Dream Scheme 10. Conclusions and Reflections: Powers of Illusion and Forces of Con-fusion
The role of ventilation and HVAC systems for human health in nonindustrial indoor environments. A supplementary review by EUROVEN group

A continuation of the earlier work of the multidisciplinary group of European scientists, EUROVEN, is presented. The group has previously concluded that increased ventilation rates in indoor nonindustrial environments are strongly associated with improved comfort and health and may be associated with increased productivity, and that air-conditioning systems may increase the risk of sick building syndrome (SBS) symptoms. Taking these findings into account, the group has elaborated 35 hypotheses on the role of ventilation and HVAC systems in non industrial indoor environments with regard to human health; 108 peer-reviewed papers have been reviewed among which 74 supported or refuted the hypotheses. The group concluded that increasing outdoor air supply rates is necessary for dilution/removal of pollutants generated indoors (including allergens), and that improper design, functioning and maintenance of ventilation and air-conditioning systems, as well their intermittent operation, may be potential reasons for health problems of people staying indoors. INDEX TERMS HVAC; Offices; Residences; Ventilation; Review; EUROVEN INTRODUCTION To create a multidisciplinary forum for an adequate communication of scientific results between different disciplines, the European Multidisciplinary Scientific Network on indoor Environment and Health concerning associations between ventilation and health, EUROVEN, was established in the year 2000 by scientists with expertise in medicine, epidemiology, toxicology and engineering. They reviewed the peer-reviewed scientific literature concerning ventilation and health in nonindustrial indoor environments and following the plenary discussions, used the results of the review to formulate a consensus statement. As a result of the work in the year 2000, the group concluded that ventilation is strongly associated with comfort (perceived air quality) and health (Sick Building Syndrome (SBS) symptoms, inflammation, infections, asthma, allergy, short-term sick leave), and that an association between ventilation and productivity (performance of office work) is indicated (Wargocki et al., 2002). Additionally, the group concluded that increasing outdoor air supply rates in * Contact author email: pw@mek.dtu. dk Proceedings: Indoor Air 2002
Pre-service teachers and ChatGPT in multistrategy problem-solving: Implications for mathematics teaching in primary schools

This study compared the problem-solving abilities of ChatGPT and 58 pre-service teachers (PSTs) in solving a mathematical word problem using various strategies. PSTs were asked to solve a problem individually. Data was collected from PSTs’ submitted assignments, and their problem-solving strategies were analyzed. ChatGPT was also given the same problem to solve with various prompts, and the correctness of its solutions and problem-solving strategies were assessed alongside those of PSTs. The results indicated that PSTs used diverse strategies and achieved accurate solutions, but not always relevant strategies to children’s level of understanding. ChatGPT employed similar strategies to PSTs but mostly produced incorrect solutions, and its performance needed to be contextualized in the primary school context. The study highlights the potential of ChatGPT in mathematics teaching and informs teacher education programs about the possibility of using it in teaching problem-solving strategies.
Strategische Planungen in naturräumlich definierten Handlungsräumen - Anpassung an den Klimawandel in der Region Starkenburg

Empfohlene Zitierung / Suggested Citation: Buchholz, Frank ; Kemper, Tobias ; Riechel, Robert: Strategische Planungen in naturräumlich definierten Handlungsräumen Anpassung an den Klimawandel in der Region Starkenburg. In: Matern, Antje (Ed.) ; Löwis, Sabine von (Ed.) ; Bruns, Antje (Ed.) ; Akademie für Raumforschung und Landesplanung Leibniz-Forum für Raumwissenschaften (Ed.): Integration Aktuelle Anforderungen und Strategien in der Stadt-, Raumund Umweltplanung : 12. Junges Forum der ARL, 10. bis 12. Juni 2009 in Hamburg. Hannover : Verl. d. ARL, 2010 (Arbeitsmaterial 353). ISBN 978-3-88838-353-3, 91-100. https://nbn-resolving.org/urn:nbn:de:0168-ssoar-355764