Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative study of sequence-to-sequence models: From RNNs to transformers

In this comprehensive exploration of sequence-to-sequence models in Natural Language Processing (NLP), we have traced the trajectory of their evolution and contributions. Starting from foundational Recurrent Neural Networks (RNNs) to the revolutionary capabilities of Long Short-Term Memory (LSTM), In this comprehensive exploration of sequence-to-sequence models in Natural Language Processing (NLP), we have meticulously traced the trajectory of their evolution and impactful contributions. From the foundational Recurrent Neural Networks (RNNs) to the revolutionary capabilities of Long Short-Term Memory (LSTM), as well as the transformative innovations brought forth by Transformers and BERT, this review eloquently highlights the monumental advancements that have fundamentally reshaped our understanding and generation of language. The crux of our comparative analysis lies in its ability to spotlight the distinctive strengths and limitations inherent in each model. Through an intricate examination, we uncover their nuanced applications across a diverse spectrum of NLP tasks. Particularly noteworthy is the pivotal role played by Transformers and the transformative Bidirectional Encoder Representations from Transformers (BERT). The paper concludes with a summary and outlook of the entire paper.
Bias correction of OMI HCHO columns based on FTIR and aircraft measurements and impact on top-down emission estimates

Abstract. Spaceborne formaldehyde (HCHO) measurements constitute an excellent proxy for the sources of non-methane volatile organic compounds (NMVOCs). Past studies suggested substantial overestimations of NMVOC emissions in state-of-the-art inventories over major source regions. Here, the QA4ECV (Quality Assurance for Essential Climate Variables) retrieval of HCHO columns from OMI (Ozone Monitoring Instrument) is evaluated against (1) FTIR (Fourier-transform infrared) column observations at 26 stations worldwide and (2) aircraft in situ HCHO concentration measurements from campaigns conducted over the USA during 2012–2013. Both validation exercises show that OMI underestimates high columns and overestimates low columns. The linear regression of OMI and aircraft-based columns gives ΩOMI=0. 651Ωairc+2.95×1015 molec.cm-2, with ΩOMI and Ωairc the OMI and aircraft-derived vertical columns, whereas the regression of OMI and FTIR data gives ΩOMI=0. 659ΩFTIR+2.02×1015 molec.cm-2. Inverse modelling of NMVOC emissions with a global model based on OMI columns corrected for biases based on those relationships leads to much-improved agreement against FTIR data and HCHO concentrations from 11 aircraft campaigns. The optimized global isoprene emissions (∼445Tgyr-1) are 25 % higher than those obtained without bias correction. The optimized isoprene emissions bear both striking similarities and differences with recently published emissions based on spaceborne isoprene columns from the CrIS (Cross-track Infrared Sounder) sensor. Although the interannual variability of OMI HCHO columns is well understood over regions where biogenic emissions are dominant, and the HCHO trends over China and India clearly reflect anthropogenic emission changes, the observed HCHO decline over the southeastern USA remains imperfectly elucidated.
Inclusive Education from Cultural Diversity and ICT

Students, in its different dimensions, aspects and contexts. Therefore, the objective of this present is to analyze the impact of inclusive education, from cultural diversity, the use of ICT in the students of the study of the "Teaching Professionalization" program of the National University of Education UNAE, in the context of Morona Santiago The methodology used was based on a mixed approach, which combined the quantitative with the qualitative, supported a descriptive study that contributed to the precision of the application of inclusion in the training processes; the method that was reduced was that of research - action that helped the researchers to take a greater role; The techniques that were implemented were: survey, interview, which were addressed to teachers and students. As results, it is evident that educational actors are an active part of the training processes, they feel included with the application of didactic strategies, digital tools, since these take into account their needs and cultural diversity. The conclusions show that social networks: WhatsApp, Facebook, YouTube, Messenger and the EVEA platform are spaces to promote inclusion.
Generalized and COVID related anxiety as risk factors for health outcomes among adolescents with HIV during COVID-19 in Tanzania

The COVID-19 pandemic and associated prevention strategies caused widespread interruptions to care and treatment for people living with HIV. Adolescents living with HIV (AWHIV) were particularly vulnerable to poor mental and physical health during COVID-19. We assessed the burden of generalized and COVID-19-related anxiety and associations with adherence to HIV care and treatment and viral load suppression (VLS) among AWHIV during the peak of the COVID-19 pandemic in Tanzania. Methods This cross-sectional study was conducted among AWHIV aged 15–19 years attending 10 clinics in Dar es Salaam from April 2022-February 2023. Study participants completed a self-administered questionnaire including Generalized Anxiety Disorder (GAD), COVID-19-related anxiety, and other psychosocial and physical health and support measures. HIV visit adherence, viral load and sociodemographic data were abstracted from patient health records. Analysis: Multivariable (MV) quasibinomial and logistic regression models examined associations of Generalized and COVID-19-related anxiety with visit adherence and HIV virologic suppression (HIV VL < 50 copies/mL). Data were analyzed using R software. Results 658 AWHIV (52% male) were included in this analysis. Most (86%) had been on antiretroviral treatment (ART) for at least four years, 55% attended at least 75% of their scheduled clinic visits, and 78% were HIV virologically suppressed. The median GAD and COVID-19-related anxiety scores were 2 (IQR: 0–5, and 26 (IQR: 13–43; respectively. Only 2% scored moderate-severe generalized anxiety (score 10–21). We found no significant associations between COVID-19-related anxiety or GAD and visit adherence. Higher GAD was inversely associated with VLS (adjusted odds ratio (AOR): 0.89 (95% CI 0.81, 0.98)). Female gender and higher quality of physical life were significantly associated with VLS. Conclusion. Low levels of generalized and COVID-19 related anxiety were reported among Tanzanian AWHIV. Integrating screening and management of generalized anxiety screening into HIV care for AWHIV could improve VLS among this population.
Neonatal Intensive Care Unit Nurses’ Knowledge and Use of Sucrose for Neonatal Pain Management in Saudi Arabia

Introduction Sucrose is an evidence-based intervention used for short-term pain management and distress from minor procedures. Limited research exists on nurses’ knowledge and use of sucrose in Neonatal Intensive Care Units in Saudi Arabia. Objective To assess nurses’ knowledge and use of sucrose in Neonatal Intensive Care Units in Saudi Arabia. Methods A cross-sectional online survey was used to collect data from a convenience sample of 68 neonatal intensive care nurses in Saudi Arabia. A modified tool assessed the knowledge and use of sucrose. Logistic regression analysis was used to find the predictors for sucrose use. Results Most respondents never used sucrose for neonatal pain management and did not receive any training on sucrose. The mean knowledge of nurses regarding sucrose and its use was very low (38%): 16% had a high level of knowledge regarding sucrose, 13% moderate, 19% low, and 52% very low. Nurses who received training on sucrose use and nurses who read or heard about sucrose predicted the use of sucrose. Conclusion Nurses’ knowledge and use of sucrose were inadequate. Interventional programs are needed to enhance the nurses’ knowledge regarding sucrose and its use and to enhance the utilization of sucrose as a pain management intervention in the Neonatal Intensive Care Units in Saudi Arabia.
The impact of COVID-19 on treatment follow-up and medication adherence among patients with epilepsy at a referral hospital in Ethiopia

Background The world continues to be challenged by the Coronavirus disease 2019 (COVID-19) and preventive measures like maintaining social distancing and lockdowns challenge patients to attend regular follow-ups and get a refill for medication that causes adherence problems. Hence, this study attempts to assess the impact of COVID-19 on treatment follow-up and medication adherence among patients with epilepsy. Method A total of 276 patients with epilepsy were enrolled in the study. Data collection was carried out through medical record reviews and patient interviews. Patients who visited Zewditu Memorial Hospital from August to September 2021 and those who had follow-up at least for two years before the outbreak of the pandemic were included. The data was analyzed using SPSS v.24. Result About 69.6% of patients were adherent to their treatment and 83.3% of the patients had a seizure-free period of less than 1 year. Ninety (32.6%) of the participants missed their treatment follow-up during the pandemic, mainly due to fear of being infected with COVID-19. Sixty-eight (24.6%) patients have experienced increased seizure episodes during the pandemic as compared to the previous times. Moreover, 56 (20.3%) participants were not taking their antiseizure medications (ASMs) during the pandemic because of the unavailability of medications and they discontinued hospital visits for their medication refills. Among those who missed their treatment follow-up, 20% had seizure-related physical injuries. Only educational level has a significant association with visiting health facilities during the pandemic. Thus, participants who completed college and above (OR = 2.58, 95% CI (1.32–6.38)) were more likely to attend their follow-up during the pandemics as compared to participants who can’t read and write. Conclusion The present study revealed that COVID-19 might have impacts on treatment follow-up and medication adherence due to fear of infection, travel restrictions and the indirect impact on the availability and affordability of medications. These might lead to poor treatment outcomes like increased seizure frequency and seizure-related physical injuries.
The crystal structure of human ferroptosis suppressive protein 1 in complex with flavin adenine dinucleotide and nicotinamide adenine nucleotide

Abstract Ferroptosis is a recently discovered form of regulated cell death characterized by its distinct dependence on iron and the peroxidation of lipids within cellular membranes. Ferroptosis plays a crucial role in physiological and pathological situations and has attracted the attention of numerous scientists. Ferroptosis suppressive protein 1 (FSP1) is one of the main regulators that negatively regulates ferroptosis through the GPX4‐independent FSP1–CoQ10–NAD(P)H axis and is a potential therapeutic target for ferroptosis‐related diseases. However, the crystal structure of FSP1 has not been resolved, which hinders the development of therapeutic strategies targeting FSP1. To unravel this puzzle, we purified the human FSP1 (hFSP1) protein using the baculovirus eukaryotic cell expression system and solved its crystal structure at a resolution of 1.75 Å. Furthermore, we evaluated the oxidoreductase activity of hFSP1 with NADH as the substrate and identified E156 as the key amino acid in maintaining hFSP1 activity. Interestingly, our results indicated that hFSP1 exists and functions in a monomeric state. Mutagenesis analysis revealed the critical role of the C‐terminal domain in the binding of substrate. These findings significantly enhance our understanding of the functional mechanism of FSP1 and provide a precise model for further drug development.
The Value of Plasma Atherogenic Index in Prognosis of Sudden Hearing Loss

Background: The impact of lipid parameters on hearing loss has been extensively studied in the literature. However, there is currently no study investigating the prognostic factor of plasma atherogenic index in patients with sudden hearing loss. This study aimed to evaluate the relationship of plasma atherogenic index in patients with sudden hearing loss. Methods: Plasma atherogenic index is calculated using the logarithmic ratio of triglycerides [mg/dL] to high-density lipoprotein cholesterol ([mg/dL]) based on lipid parameters. The patients were divided into tertiles according to their plasma atherogenic index values and the role of plasma atherogenic index on prognosis was investigated among the tertiles. The difference between baseline and control audiometer values for each patient was calculated, and a linear regression analysis was used to determine its statistical significance. Results: A total of 84 sudden hearing loss patients (57 male: 68%; 27 female: 32%) were included in the study. The mean age of the study participants was 45.3 ± 14.0. There was an inverse relationship between plasma atherogenic index and difference of audiometer values. Linear regression analyses revealed odds ratio and 95% confidence intervals of 0.405 (0.123-1.331) with P = . 135 for 500 Hz, 0.371 (0.071-0.990) with P = . 048 for 1000 Hz, 0.319 (0.119-0.851) with P = . 024 for 2000 Hz and 0.406 (0.161-0.992) with P = . 049 for 4000 Hz. Conclusion: To the best of our knowledge, this is the first study to demonstrate that plasma atherogenic index can serve as an indicator of a poor prognosis in the treatment of sudden hearing loss. Keywords: Atherosclerosis, sudden hearing loss, LDL cholesterol, cardiovascular disease, lipid metabolism
Time to develop adverse drug reactions and associated factors among children HIV positive patients on antiretroviral treatment in North West Amhara Specialized Hospitals: Retrospective cohort study, 2022

Abstract Introduction Adverse drug reactions (ADRs) are harmful and unintended reactions to medicines given at standard doses through a proper route of administration for the purpose of prophylaxis, diagnosis, or treatment. Objective The objective of this research paper was to assess median time to development of ADRs and associated factors among children HIV positive patients on antiretroviral treatment (ART) in North West Amhara Specialized Hospitals. Methods The adverse drug effect survival time was estimated using the Kaplan–Meier survival method and log‐rank test curves was applied for analyze “time‐to‐event” data. Cox regression model was used to identify the associated factors. Adjusted hazard ratios with their respective 95% confidence intervals (CIs) were estimated and a value of p less than 0.05 was used to declare the presence of a significant association. Result The overall incidence of ADRs was 0.67 (95% CI: 3.74–4.44) per 10,000 person‐year observation, with a median of 57 months. Adults are presenting with opportunistic Infections (OIs) experiences, baseline CD4 < 200 cells/µL counts, 1e, tenofovir disoproxil fumarate–lamivudine–efavirenz ART regimen, bedridden baseline functional status, World Health Organization (WHO) clinical stage II and III were notably associated with the incidence of ADRs development. Conclusion ADRs were uncommon in this study. predictors, such as OIs experiences, a low CD4 count, ART regimen, an advanced WHO stage, and bedridden functional status were significantly associated with ADRs.
Insertion Results and Hearing Outcomes of a Slim Lateral Wall Electrode

Background: The clinical outcomes of cochlear implantation vary for several reasons. It is necessary to study the different electrodes and variables for further development. The aim of this study is to report the clinical outcomes of a new slim lateral wall electrode (SlimJ). Methods: Data of 25 cochlear implantations in 23 patients with the SlimJ electrode were retrospectively collected. The insertion results were assessed by image fusion of the preoperative computed tomography (CT), magnetic resonance imaging (MRI), and postoperative cone-beam CT. The hearing outcomes were evaluated by the improvement of speech recognition in noise, measured preoperatively and at follow-up. Postoperative pure-tone thresholds were obtained in cases with preoperative functional low frequency hearing [PTA (0.125-0.5 kHz) ≤ 80 dB HL]. Results: The preoperative mean speech reception threshold (SRT) was +0.6 dB signal-to-noise ratio (SNR) (SD ± 4.2 dB) and the postoperative −3.5 dB SNR (SD ± 2.3 dB). The improvements between the preoperative and postoperative SRT levels ranged from 0.0 to 15.1 dB, with a mean improvement of 4.2 dB (SD ± 3.6 dB). Residual hearing in low frequencies (mean PTA(125-500 Hz)) was preserved within 30 dB HL in 70% and within 15 dB HL in 40% of patients who had preoperatively functional low frequency hearing. Mean insertion depth angle (IDA) was 401° (SD ± 41°). We observed scalar translocations from scala tympani to scala vestibuli in 2 ears (9%). Conclusion: The relatively atraumatic insertion characteristics make the SlimJ array feasible for hearing preservation cochlear implantation. The hearing outcomes are comparable to those reported for other electrodes and devices.
The Sun-Coral Project: the first social-environmental initiative to manage the biological invasion of Tubastraea spp. in Brazil

In the 1980s two invasive azooxanthellate corals, Tubastraea coccinea Lesson, 1829 and Tubastraea tagusensis Wells, 1982 (Dendrophyllidae) invaded the Southwest Atlantic. In Brazil, they were first reported from fouling on oil platforms’ and have expanded their range along 3,500km of the coastline. The Sun-Coral Project (PCS) was launched in 2006 as an outreach program aimed at the restoring marine ecosystems, mitigating the environmental damage and redressing the social and economic impacts caused to coastal communities by the sun corals. We train collectors to manually remove the corals from the seabed and earn extra income by selling the skeletons, which are used in craftwork sold to tourists. Engaging human coastal communities in management allowed it to contribute to local sustainable development. The aim of this study was to critically evaluate the first ten years of PCS as a management initiative. We 1) analysed the contribution of PCS to scientific knowledge by carrying out a systematic literature search; 2) reviewed the contribution of the regional and community monitoring program to management planning; 3) analysed management results; 4) identified social-economic effects of extra-income; 5) synthesized information regarding the structure of PCS and the role of environmental education, capacity building, training and communication. PCS is structured into training, environmental restoration, extra income and sustainability, communication, monitoring and research programs. Environmental education is present across all programs. A hotline receives new records, a task force is available for first response management and training, a Visitor’s Center was created for communication and as a field base, and a National Sun Coral Records Database was created to gather all information. The PCS Database compiled historical records and demonstrated that the sun corals continued to expand along the Brazilian coastline during the study period (2006–2016). PCS’s Research, Development and Innovation (R&D&I) Network (14 institutions, 35 members) contributed to knowledge producing 70% of publications dealing with the sun corals in Brazil. Monitoring was able to map distribution and range expansion at 326 monitored sites over four regions. Twenty five different types of outreach actions were identified which directly affected 143,000 people. Two hundred and thirty thousand sun-coral colonies (8.5 T) have been manually removed through 165 control and eradication actions. Eighty six percent of the 22 collectors and their 80 family members said their lives improved due to the extra income. The results presented here demonstrate that PCS has created a science-based, community supported, conservation initiative which provides information for government, the scientific community and stakeholders, as well as extra-income, methods and human resources for monitoring and managing the sun corals invasion.
Exploring the molecular mechanisms of increased intensity of pyrethroid resistance in Central African population of a major malaria vector Anopheles coluzzii

Abstract Molecular mechanisms driving the escalation of pyrethroid resistance in the major malaria mosquitoes of Central Africa remain largely uncharacterized, hindering effective management strategies. Here, resistance intensity and the molecular mechanisms driving it were investigated in a population of Anopheles coluzzii from northern Cameroon. High levels of pyrethroid and organochloride resistance were observed in An. coluzzii population, with no mortality for 1× permethrin; only 11% and 33% mortalities for 5× and 10× permethrin diagnostic concentrations, and <2% mortalities for deltamethrin and DDT, respectively. Moderate bendiocarb resistance (88% mortality) and full susceptibility to malathion were observed. Synergist bioassays with piperonyl butoxide recovered permethrin susceptibility, with mortalities increasing to 53.39%, and 87.30% for 5× and 10× permethrin, respectively, implicating P450 monooxygenases. Synergist bioassays with diethyl maleate (DEM) recovered permethrin and DDT susceptibilities (mortalities increasing to 34.75% and 14.88%, respectively), implicating glutathione S‐transferases. RNA‐seq‐based genome‐wide transcriptional analyses supported by quantitative PCR identified glutathione S‐transferase, GSTe2 (RNA‐seqFC = 2.93 and qRT‐PCRFC = 8.4, p < 0.0043) and CYP450, CYP6Z2 (RNA‐seqFC = 2.39 and qRT‐PCRFC = 11.7, p < 0.0177) as the most overexpressed detoxification genes in the pyrethroid‐resistant mosquitoes, compared to mosquitoes of the susceptible Ngousso colony. Other overexpressed genes include P450s, CYP6M2 (FC = 1.68, p < 0.0114), CYP4G16 (FC = 2.02, p < 0.0005), and CYP4G17 (FC = 1.86, p < 0.0276). While high frequency of the 1014F kdr mutation (50%) and low frequencies of 1014S (6.61%) and 1575Y (10.29%) were observed, no ace‐1 mutation was detected in bendiocarb‐resistant populations, suggesting the preeminent role of metabolic mechanism. Overexpression of metabolic resistance genes (including GSTe2 and CYP6Z2 known to confer resistance to multiple insecticides) in An. coluzzii from the Sudan Savannah of Cameroon highlights the need for alternative management strategies to reduce malaria burden in northern Cameroon.
Late Jurassic – Early Cretaceous continental extension in northeast Asia – Relationships to plate kinematics

Northeast Asia is the greatest area in the world where continental extension is documented, from Transbaikalia to the Pacific coast. The major extensional events occurred during Late Jurassic - Early Cretaceous times and are marked by rift basins filled with continental sediments and volcanic rocks, metamorphic core complexes, and extensive magmatism. Here, we review the different types of extensional structures in the region using our own examples from eastern Mongolia, including new data from the Gobi area, and those previously documented in the adjacent regions. We further provide a compilation of available ages, including new data from Transbaikalia, to constrain crustal stretching throughout northeastern Asia. Our analysis shows that extension is not correlated to orogenic collapse, but is coeval with two major changes in plate kinematics that occurred at ca. 140 Ma: the closure of the Mongol-Okhotsk Ocean and a major change in the subduction direction of the Izanagi oceanic plate towards northeast Asia, from high-angle to low-angle convergence. These major changes in plate kinematics combined with an abnormally hot pre-extension state of the continental lithosphere might have triggered spreading in northeast Asia.