Miracle-dz/UniFAR-FTUs huggingface dataset:
Terapi Doxycycline Pada Laki-laki Homoseksual dengan Sifilis Sekunder dan Infeksi Human Immunodeficiency Virus

Pendahuluan: Re-emergence sifilis banyak ditemukan pada laki-laki homoseksual dengan infeksi HIV positif. Perjalanan penyakit sifilis pada pasien dengan HIV lebih cepat dan berisiko tinggi menjadi neurosifilis. Koinfeksi sifilis dan human immunodeficiency virus (HIV) dikaitkan dengan penurunan CD4 dan peningkatan HIV-RNA. Perbaikan keduanya dikaitkan dengan terapi sifilis yang efektif, salah satunya dengan terapi doxycycline. Doxycycline memiliki efek antiinflamasi yang berhubungan dengan penurunan viral load serta peningkatan CD4 pada pasien positif HIV. Kasus: Laki-laki warga negara asing berusia 20 tahun dengan keluhan utama bintik merah tidak gatal pada sekujur tubuh yang muncul selama 2 hari disertai demam. Pasien sudah berobat namun belum tampak perbaikan. Riwayat berhubungan seksual sesama jenis dan bergonta-ganti pasangan lebih dari 10 kali dalam 10 tahun terakhir serta jarang menggunakan kondom. Regio generalisata tampak papul eritem multipel diskret berukuran miliar hingga lentikular. Regio skrotum dan penis pasien terdapat lesi makula eritema, plak indurasi sewarna kulit multipel berbatas tegas. Teraba pembesaran kelenjar getah bening regio inguinalis. Pemeriksaan VDRL 1:32 dan TPHA 1:640. Hasil pemeriksaan HIV reaktif 241,50 dengan nilai CD4 558 sel/ml. Pasien diedukasi untuk menjalani abstinensi hubungan seksual. Terapi yang diberikan adalah doxycycline 2x100 mg selama 14 hari, serta ARV nevirapine, lamivudine dan zidovudine. Pasien mengalami perbaikan manifestasi klinis dalam sebulan pengobatan. Pemeriksaan VDRL saat kontrol bulan ketiga adalah 1:2 dengan CD4 570 sel/ml. Pembahasan: Doxycycline merupakan lini kedua untuk tata laksana penyakit sifilis yang berdasarkan studi mampu membantu menurunkan viral load dan meningkatkan jumlah CD4 pada penderita sifilis dengan HIV. Pada kasus ini, penurunan titer VDRL pasien secara signifikan dibanding titer awal mengindikasikan keberhasilan terapi. Hasil pemeriksaan CD4 pasien juga mengalami kenaikan pada bulan ketiga.
The African Cooperation within Egypt-Sudan using Multimodal Transportation: Systematic Review Paper

Purpose: Investigating the advancements and implementation facilities required in Egypt and Sudan in terms of Multimodal transport to maximize Egypt's economic gains within the footprints of the agreements between the two nations and African cooperatives. To strike a balance between social, economic, and environmental concerns, the Egyptian government prioritizes transportation projects as part of its ambitious objective of providing and integrating varied transportation networks and technologies. Methodology: Conducting a comprehensive, systematic literature review of 55 published studies in order to compile the most significant published papers matching the research keywords, supporting the theoretical contributions of the research and the previous researchers' recommendations for the subsequent studies, by assessing primary data collected through semi-structured interviews with Egyptian and African transport authority officials. Results: It has been shown that too few research studies have used the river connection to disrupt commerce flow in order to examine multimodal transportation. There has also been no further inquiry into the border terminals and route networks between Egypt and Sudan that might help in the enhancement of the countries' import and export operations, notably the upgrading and modernization of ports in Nile Basin countries, despite the fact that increased activities, services, and hubs might help both countries' transportation networks, seaports and logistics networks surrounded by Africa. Unique Contribution to Theory, Policy and Practices: The research provides an original contribution to the literature by identifying the impact of cooperation in terms of transport sector by improving inter-modality services and logistics services between the two countries. A network of highways linking Egypt and Sudan will gain better benefits using data from real investigations and theoretical models established by the researcher, but it will need considerable exploration and actuality.
Devil’s Advocate or Advocate of Oneself: Effects of Numerical Support on Proand Counterattitudinal Self-Persuasion

The impact of minority and majority support on attitude change is examined in a self-persuasion task. Two studies show that pro-attitudinal advocacy for the majority leads to more self-persuasion than does advocacy for the minority. In contrast, devil’s advocacy for a minority leads to stronger self-persuasion than for a majority. No differences are found with respect to the number and nature of the arguments generated. Results suggest that self-persuasion is mediated by the extent to which one perceives the group of people argued for as similar to oneself. Two follow-up studies manipulating similarity to the group argued for support of this notion. When arguing for an ingroup, arguing for the majority is more self-persuasive than is arguing for the minority. Conversely, arguing for an outgroup leads to stronger self-persuasion for a minority than for a majority, because the minority is perceived as less threatening.
48 W Continuous-Wave Output From a High- Efficiency Single Emitter Laser Diode at 915 nm

Improving the power and efficiency of 9xx-nm broad-area laser diodes has a great help in reducing the cost of laser systems and expanding applications. This letter presents an optimized epitaxial structure with high power and conversion efficiency. Laser diodes with 230 $\mu \text{m}$ emitter width and 5 mm cavity length deliver continuous-wave output power up to 48.5 W at 48 A, 30 °C, the highest power reported for 9xx-nm single emitter lasers so far. The slope efficiency is as high as 1.23 W/A due to a low internal optical loss of 0.31 cm−1 and a high internal efficiency of 96%. The maximum power conversion efficiency reaches 72.6% at 15.3 W and 67.3% at the operating power of 30 W under a heatsink temperature of 25 °C. Life test results show no failure in 1000 hours for 55 laser diodes.
A model of carbon production in a cometary coma

A model of the cometary ionosphere is developed in order to account for the large population of metastable C(D-1) atoms detected via the ultraviolet spectrum of Comet West (1976 VI). Dissociative recombination of CO(plus) ions and electrons is shown to be the dominant source of carbon atoms rather than photodissociation of CO so that the derived carbon production rate is only a lower limit to the evaporation rate of the carbon bearing mother molecule.
Ranked Based Procedures for Ordered Alternative Models

The ordered alternatives in a one-way layout with k ordered treatment levels are appropriate for many applications, especially in psychology and medicine. There is an extensive literature in this area, and many parametric and nonparametric approaches have been introduced. A new rank-based procedure has been developed, which has the same optimal efficacy properties as the Hettmansperger-Norton (1987) procedure for ordered and umbrella alternative problems, including the unknown peak problem. This rank-based procedure can utilize general score functions and is easily extended to linear and mixed models. This poster briefly discusses the new method and the simulation resutls.
Ataques Automatizados de Engenharia Social com o uso de Bots em Redes Sociais Profissionais

As interações humanas virtuais têm sido ampliadas com o uso crescente da Internet e redes sociais, elevando os riscos de ameaças cibernéticas de Engenharia Social. O uso de Bots nesses ataques permite escalabilidade na exploração da confiança dos usuários, provocando riscos de segurança. Poucos são os trabalhos com foco nas ações automatizadas de Engenharia Social com o uso de Bots. Este artigo apresenta uma verificação dos controles de uma rede social profissional quanto à identificação e bloqueio desses ataques automatizados, utilizando um Bot de prova de conceito. A análise e discussão dos resultados permite demonstrar as vulnerabilidades de segurança presentes nas redes profissionais que podem ser exploradas para construção da relação de confiança do usuário com um Bot malicioso.
Evaluation of the gn-->pi-p differential cross sections in the Delta-isobar region

Differential cross sections for the process gn-->pi-p have been extracted from MAMI-B measurements of gd-->pi-pp, accounting for final-state interaction effects, using a diagrammatic technique taking into account the NN and piN final-state interaction amplitudes. Results are compared to previous measurements of the inverse process, pi-p--> ng, and recent multipole analyses.
Enhanced Antioxidant Effects of Naringenin Nanoparticles Synthesized using the High-Energy Ball Milling Method

Naringenin, one of the flavonoid components, is majorly found in and obtained from grapefruits and oranges. Naringenin also acts as a potent antioxidant, which possesses hypolipidemic as well as anti-inflammatory potential. Naringenin reduces the expressions of several inflammatory mediators, viz., NF-κB, cycloxygenase-2, and other cytokine mediators. In spite of having various biological effects, the clinical application of naringenin is restricted due to its very poor aqueous solubility. In the present study, the high-energy ball milling method was employed for the preparation of naringenin nanoparticles without using any chemical with an aim to enhance the anti-oxidant potential of naringenin. The milled naringenin nanoparticles were characterized for their physicochemical properties using scanning electron microscopy (SEM) and X-ray diffraction. Additionally, the effects of milling time and temperature were further assessed on the solubility of crude and milled naringenin samples. The antioxidant potential of milled naringenin was evaluated with various assays such as DHE, DCFDA, and cleaved caspase-3 using SH-SY5Y human neuroblastoma cells. The nanoparticle size of naringenin after milling was confirmed using SEM analysis. Crystalline peaks for milled and crude samples of naringenin also established that both the naringenin forms were in the crystalline form. The solubility of naringenin was enhanced depending on the milling time and temperature. Moreover, crude and milled naringenin were found to be cytocompatible up to doses of 120 μM each for the duration of 24 and 48 h. It was also observed that milled naringenin at the doses of 1, 2, and 5 μM significantly reduced the levels of reactive oxygen species (ROS) generated by H2O2 and exhibited superior ROS scavenging effects as compared to those of crude or un-milled forms of naringenin. Furthermore, milled naringenin at the doses of 1 and 2 μM inhibited H2O2-induced cell death, as shown by immunofluorescence staining of cleaved caspase-3 and Annexin-V PI flow cytometry analysis. Conclusively, it could be suggested that the size reduction of naringenin using high-energy ball milling techniques substantially enhanced the antioxidant potential as compared to naïve or crude naringenin, which may be attributed to its enhanced solubility due to reduced size.
Polarization Matters: On Bilinear Convolutional Neural Networks for Ship Classification From Synthetic Aperture Radar Images

Ship classification using synthetic aperture radar (SAR) images plays a core role in modern maritime surveillance. Traditional classification methods mainly applied the handcrafted features for ship representation in SAR images, which can hardly deal with the resolution-limited SAR images well. Recently, deep learning methodology opens a new door for effective and efficient SAR ship classification. This paper is dedicated to make a deep exploration on the convolutional neural networks (CNNs) for SAR ship classification. First, a novel two stream CNN framework is proposed to sufficiently utilize the polarization information in SAR images. Second, bilinear pooling is applied to the deep CNN features from two single polarization SAR images, hence more discriminative ship representations are acquired. Third, to mitigate the defect of small-scale SAR ship data set for training the deep CNNs, we propose to finetune the large-scale data pretrained CNN models by task-specific SAR ship data. Extensive experiments demonstrate the effectiveness of the proposed SAR ship classification framework.
Sustainable Fiber‐Reinforced Composites: A Review

Sustainable fiber reinforced polymer (FRP) composites from renewable and biodegradable fibrous materials and polymer matrices are of great interest, as they can potentially reduce environmental impacts. However, the overall properties of such composites are still far from the high‐performance conventional glass or carbon FRP composites. Therefore, a balance between composite performance and biodegradability is required with approaches to what one might call an eco‐friendly composite. This review provides an overview of sustainable FRP composites, their manufacturing techniques, and sustainability in general at materials, manufacturing, and end‐of‐life levels. Sustainable plant‐based natural fibers and polymer matrices are also summarized, followed by an overview of their modification techniques to obtain high‐performance, multifunctional, and sustainable FRP composites. Current state‐of‐the‐art mechanical and functional properties of such composites are then surveyed, and an overview of their potential applications in various industries, including automobile, aerospace, construction, medical, sports, and electronics is provided. Finally, future market trends, current challenges, and the future perspective on sustainable natural FRP composites are discussed.
Doxorubicin-Induced TrkAIII Activation: A Selection Mechanism for Resistant Dormant Neuroblastoma Cells

Patients with advanced neuroblastoma (NB) receive multimodal clinical therapy, including the potent anthracycline chemotherapy drug doxorubicin (Dox). The acquisition of Dox resistance, however, is a major barrier to a sustained response and leads to a poor prognosis in advanced disease states, reinforcing the need to identify and inhibit Dox resistance mechanisms. In this context, we report on the identification and inhibition of a novel Dox resistance mechanism. This mechanism is characterized by the Dox-induced activation of the oncogenic TrkAIII alternative splice variant, resulting in increased Dox resistance, and is blocked by lestaurtinib, entrectinib, and crizotinib tyrosine kinase and LY294002 IP3-K inhibitors. Using time lapse live cell imaging, conventional and co-immunoprecipitation Western blots, RT-PCR, and inhibitor studies, we report that the Dox-induced TrkAIII activation correlates with proliferation inhibition and is CDK1- and Ca2+-uniporter-independent. It is mediated by ryanodine receptors; involves Ca2+-dependent interactions between TrkAIII, calmodulin and Hsp90; requires oxygen and oxidation; occurs within assembled ERGICs; and does not occur with fully spliced TrkA. The inhibitory effects of lestaurtinib, entrectinib, crizotinib, and LY294002 on the Dox-induced TrkAIII and Akt phosphorylation and resistance confirm roles for TrkAIII and IP3-K consistent with Dox-induced, TrkAIII-mediated pro-survival IP3K/Akt signaling. This mechanism has the potential to select resistant dormant TrkAIII-expressing NB cells, supporting the use of Trk inhibitors during Dox therapy in TrkAIII-expressing NBs.
The risk factors of the functional status, quality of life, and family psychological status in children with postintensive care syndrome: A cohort study

Background: Intensive care treatment has a side effect of several impairments after hospital discharge, known as postintensive care syndrome (PICS). PICS in children must be well evaluated because PICS can affect their global development and quality of life. Our specific aims are to determine the impact of intensive care treatment and the risk factors which contribute to PICS. Methods: In this observational cohort study, we identified critically ill children treated in intensive care units (ICUs) for more than 24 h and survived. We evaluated the internal and external risk factors of the patients in the intensive care. We interviewed their parents to define the functional status and quality of life of the patients in 7 days before ICU admission and the psychological status of the family at the time of intensive care admission. The interview was repeated in 3 months after the intensive care discharge. Results: There was a significant decrease in functional status and quality of life after intensive care treatment (P < 0.001). However, none of the internal risk factors were significantly associated with PICS. Neurologic involvement in the disease was associated with the significantly reduced functional status of patients, while the severity of the disease was significantly associated with both functional status and quality of life. Our study also showed a significant psychological disorder of the family in the intensive care. Conclusion: The occurrence of PICS in children was associated with the severity of the disease, decreased the functional status and quality of life, and contributed to psychological disorders for the family.
LSB-based Random Embedding Image Steganography Technique Using Modified Collatz Conjecture

With digital communication breakthroughs, reliable data security and secure sharing of secret information remain a challenge. LSB is considered one of the most used techniques in steganography because of its simple and easy implementation. However, the algorithm can easily be broken down, and the attacker can obtain the secret message due to its simplicity. This paper combines Diffie-Hellman Key Exchange with a modified Collatz Conjecture to generate unique random numbers. The generated random numbers are used to identify the unique pixel locations where the secret message will be embedded. The simulation results using INRIA Holiday datasets yielded PSNR and SSIM mean values of 69.24 and 0.9999, respectively, which are favorable enough to conclude that the employed method generates highly imperceptible stego-images. Furthermore, the probability of detection using statistical attacks like RS Analysis and Sample Pair Analysis was fortunately minimal, leading to stego-images that are resistant to statistical attacks.
Dynamical pattern formation upon dewetting

Dewetting of thin liquid films is monitored in situ by atomic force microscopy, results are compared with simulations. The experimental setting is mimicked as close as possible using the experimental parameters including the effective interface potential. Numerics for the thin film equation are based on recently developed schemes which are up to now the only methods convergent in all relevant space dimensions. Temporal evolution and morphology of experiment and simulation are compared quantitatively. Our results explain the origin of complex generic patterns that evolve upon dewetting.
REVIEW ARTICLE: Effects of light on molecular orientation of liquid crystals

A review of basic physical phenomena underlying the light-induced molecular reorientation in nematic liquid crystals is presented. A detailed description of the mechanisms of direct optical torque, photoisomerization and photorefractivity and of their effect on the macroscopic order of liquid crystals is reported. The first part of the article deals with the study of reorientation effects in transparent liquid crystalline materials. Here, the effects of photo-induced molecular reorientation are fully interpreted within the framework of classical electrodynamics and standard continuum theory of liquid crystals. We investigate the peculiar properties related to the macroscopic anisotropy and the collective behaviour of liquid crystals that result in extraordinarily large nonlinear optical response. Afterwards, the behaviour of liquid crystals in the presence of light absorption is considered and the related reorientation effects are discussed. We give a review of the wide phenomenology which is met in liquid crystals when doped with absorbing azo-dye molecules. The photoisomerization process that in this case drives the evolution of the dye-liquid crystal mixture consequent to the interaction with the light is discussed in detail. Finally, the relatively new field of photorefractivity in liquid crystals as a source of molecular reorientation is considered. We describe the different mechanisms contributing to the creation of a space-charge field such as conductivity anisotropy, dielectric anisotropy and photocharge production. A theoretical discussion of the fundamental mechanisms regulating the dc-field-assisted optically induced space-charge fields and the optical molecular reorientation in nematic liquid crystal films is also given.
Multi-Channel Back-Projection Algorithm for mmWave Automotive MIMO SAR Imaging With Doppler-Division Multiplexing

Due to the low-cost and compact size, millimeter-wave radar is gaining increasing attention in automotive applications. Compared with the array imaging technique, synthetic aperture radar (SAR) takes advantage of high resolution, low system complexity, and is an important powerful tool in automotive radar imaging. In this paper, a high-resolution MIMO SAR imaging algorithm is proposed in the framework of Doppler-division multiplexing (DDM), where a novel multi-channel back-projection (BP) approach is presented for coherent multi-channel image integration. In the scheme, the DDM is applied on transmitter and Doppler filtering is employed to separate echoes of different transmitters on one receiver. Then the proposed multi-channel BP algorithm is divided into two parts. The first step corresponds to the BP SAR imaging on each channel, effectively dealing with the problem of near-field and wide-angle focusing. As follows, digital beamforming (DBF) and beampattern synthesis based on alternating direction method of multipliers (ADMM) is used for multi-channel SAR image coherent fusion. Experiments using real-measured data from an automotive radar system with a two-transmitter-eight-receiver array validate the effectiveness of the proposed algorithm.
Social Expansion versus Social Fragmentation

The process of social expansion in Europe can be better understood with various concepts related to complexity science. Findings of exploratory research show a typical process of social expansion in Europe within the period 1495-1945, in which wars have been instrumental. Furthermore, this research enables the identification of vulnerabilities, and conditions for success in a process of social expansion.
Bounded distance control for Multi-UAV formation safety and preservation in target-tracking applications

The notion of safety in multi-agent systems assumes great significance in many emerging collaborative multi-robot applications. In this paper, we present a multi-UAV collaborative target-tracking application by defining bounded inter-UAV distances in the formation in order to ensure safe operation. In doing so, we address the problem of prioritizing specific objectives over others in a multi-objective control framework. We propose a barrier Lyapunov function-based distributed control law to enforce the bounds on the distances and assess its Lyapunov stability using a kinematic model. The theoretical analysis is supported by numerical results, which account for measurement noise and moving targets. Straight-line and circular motion of the target are considered, and results for quadratic Lyapunov function-based control, often used in multi-agent multi-objective problems, are also presented. A comparison of the two control approaches elucidates the advantages of our proposed safe-control in bounding the inter-agent distances in a formation. A concluding evaluation using Robot Operating System simulations illustrates the practical applicability of the proposed control to a pair of multi-rotors visually estimating and maintaining their mutual separation within specified bounds, as they track a moving target.