Miracle-dz/UniFAR-FTUs huggingface dataset:
Study on mineral composition design and mechanical properties improvement mechanism of high ferrite oil well cement

In shale gas production, secondary fracturing technology is often used to improve shale gas production capacity. However, the toughness of cement stone used in Class G oil wells is poor, and the cement sheath is easily damaged by impact load during fracturing, resulting in cement sheath sealing failure. To solve this problem, this paper proposes to improve the strength and toughness of cement paste by optimizing the mineral composition of Class G oil well cement. The cement clinker is burned in the laboratory, and the microstructure differences of clinker under different mineral composition ratios are observed by reflection microscope. The mechanical properties of cement paste before and after optimization are analyzed, and the best mineral composition ratio is obtained. The petrographic structure, hydration products and microstructure of high ferrite oil well cement were analyzed by petrography, X-ray diffraction analysis (XRD), thermal analysis (TG/DTG) and scanning electron microscopy (SEM), analyzed and explored its enhancement mechanism. The results show that the best mineral composition mass ratios of C3S, C2S, C3A and C4AF in high ferrite oil well cement are 58.34%, 16.39%, 1.51% and 17.94% respectively. Compared with grade G oil well cement, the compressive strength and flexural strength of curing 28 days are increased by 14.11% and 19.51%, respectively. The stress-strain results show that high ferrite oil well cement has better toughness. The petrographic results show that the lithofacies structure of high ferrite oil well cement is evenly distributed and the particle size is moderate; XRD, TG/DTG and microanalysis show that there are more hydration products in high ferrite oil well cement, the hydration products are closely combined, the hydration degree is more thorough, and the structure of cement paste is more compact. High ferrite oil well cement has the advantages of high strength and good toughness, which has potential advantages for shale gas cementing.
COVID-19 alters the relationship between relational mobility and helping behavior

To determine if helping behaviors are affected by socioecological variables such as relational mobility and the COVID-19 pandemic, we investigated the impact of relational mobility on helping behaviors before (Study 1) and during (Study 2) COVID-19 in China via two experiments. In Study 1, we manipulated participants’ relational mobility and found that a greater proportion of participants in the high relational mobility condition signed up for another psychological experiment, relative to the low relational mobility condition. In Study 2, the manipulation of relational mobility was embedded in a phone interview, and we found that a high relational mobility condition caused fewer signups for a COVID-19 support program relative to a low relational mobility condition. These results extend our understanding of the meaning of relational mobility under different ecological contexts.
Beyond double-resonant Raman scattering: Ultraviolet Raman spectroscopy on graphene, graphite, and carbon nanotubes

The study of Raman scattering processes in the ultraviolet excitation energy range is not common in carbon-based materials. This paper reports that the widely known double-resonant Raman scattering, which is dominant in the visible excitation energy in these materials, is suppressed in the UV range. This is an important development because one can now measure two-phonon densities of states that were not accessible before. The results demonstrate the high potential of UV Raman spectroscopy for research on graphitic nanocarbons.
Efficacy of computed tomography in diagnosing pulmonary hypertension: A systematic review and meta-analysis

Objective This study seeks to evaluate the diagnostic value of computed tomography (CT) in pulmonary hypertension. Method PubMed, Embase, Scopus, and Web of Science databases were searched to obtain the relevant English literature, and the retrieval time until June 2022. The quality of the included studies is evaluated using the QUADAS-2 tool. The quality of the included studies was assessed, followed by a meta-analysis, analyze heterogeneity, summarize sensitivity and specificity, draw the comprehensive subject working characteristics (sROC) curve, calculate the area under the curve and conduct subgroup analysis and sensitivity analysis to find the source of the heterogeneity. Results A total of 12 articles were included, all with pulmonary artery diameter/liter aortic diameter >1 or 1 as the diagnostic criteria for pulmonary hypertension, and a total of 1,959 patients were included. Deek’s funnel plot analysis suggests that there is no significant publication bias (P = 0.102). The combined sensitivity was 0.652 (95% CI: 0.579, 0.719), combined specificity was 0.830 (95% CI: 0.796, 0.880), positive likelihood ratio was 3.837 (95% CI: 3.215, 4.579), negative likelihood ratio was 0.419 (95% CI: 0.346, 0.507), diagnostic odds ratio was 9.157 (95% CI: 6.748, 12.427) and area under the summary receiver operating characteristic (SROC) curve was 0.84 (95% CI: 0.81, 0.87). Conclusion The CT examination of pulmonary artery diameter/aortic artery hypertension is worthy of clinical application.
Resonance phenomena in ultracold dipole–dipole scattering

Elastic scattering resonances occurring in ultracold collisions of either bosonic or fermionic polar molecules are investigated. The Born–Oppenheimer adiabatic representation of the two-body dynamics provides both a qualitative classification scheme and a quantitative WKB quantization condition that predicts several sequences of resonant states. It is found that the near-threshold energy dependence of ultracold collision cross sections varies significantly with the particle exchange symmetry, with bosonic systems showing much smoother energy variations than their fermionic counterparts. Resonant variations of the angular distributions in ultracold collisions are also described.
EIF2S2 is a novel independent prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma

Background: Hepatocellular carcinoma (HCC) is a highly malignant disease with poor prognosis. It is urgent to find effective biomarkers. Eukaryotic Translation Initiation Factor 2 Subunit Beta (EIF2S2) is a subunit of heterotrimeric G protein EIF2, and its function is still unclear. We studied the role of EIF2S2 in the malignant progression of liver cancer and its relationship with immune infiltration. Methods: Download the RNA expression and clinical information of EIF2S2 from the Cancer Genome Atlas (TCGA) database, analyze the relationship between the expression of EIF2S2 and the prognosis and clinicopathological characteristics of HCC, analyze the differential genes by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and tumor related immune infiltrating cells. The Protein expression level of EIF2S2 was obtained from Human Protein Atlas (HPA) databases. The relationship between EIF2S2 expression and immune infiltrates in HCC was analyzed on TIMER 2.0. The data processing analysis based on R language. Drug Sensitivity data from Genomics of Drug Sensitivity in Cancer (GDSC). Results: EIF2S2 is highly expressed in HCC patients and is associated with poor prognosis. The expression of EIF2S2 was also correlated with age, clinical stage and pathological grade. Univariate and multivariate COX regression analysis showed that EIF2S2 was an independent risk factor for survival. The receiver operating characteristic (ROC) curve of EIF2S2 also confirmed the diagnostic value of EIF2S2 in HCC patients. Through GO and KEGG enrichment analysis, EIF2S2 expression was found to be closely related to some immune pathways. The expression of EIF2S2 was correlated with memory B cell, plasma B cell, CD8+ T cell, CD4+ resting memory T cell and the expression of some immune checkpoints, such as PDCD1, TIGIT and CTLA-4. It is also more sensitive to paclitaxel, sunitinib and other drugs. Conclusion: This study shows that EIF2S2 can be used as a prognostic factor for HCC, which is closely related to immune infiltration and immune checkpoints, and may play a potential regulatory role in predicting drug sensitivity.
Case report: Anti-GAD65 antibody-associated autoimmune encephalitis following HPV vaccination

Human papillomavirus (HPV) infection is a sexually transmitted disease that may lead to cervical cancer. HPV vaccines have been implemented widely to prevent this. While generally few complications of vaccination are reported, there have been occasional reports of adverse reactions post-vaccination. The safety profile of the HPV vaccine is reassuring. However, since its introduction, several serious post-vaccination central nervous system complications have been reported; however, causality has not been established. Herein, we describe a 39-year-old woman who developed seizures and experienced a rapid decline in memory shortly after her first dose of the HPV vaccine. Cranial magnetic resonance imaging and cerebrospinal fluid analysis were performed, and the patient was diagnosed with anti-glutamic acid decarboxylase 65 (anti-GAD65) antibody-associated autoimmune encephalitis. She responded well to high-dose glucocorticoids. Four-month follow-up revealed full recovery and absence of recurrence. Since the HPV vaccine is administered worldwide, this case should raise clinicians' awareness regarding the possible CNS complications related to vaccinations, such as anti-GAD65 antibody-associated AE.
Interplay of Kondo and superconducting correlations in the nonequilibrium Andreev transport through a quantum dot

Using the modified perturbation theory, we theoretically study the nonequilibrium Andreev transport through a quantum dot coupled to normal and superconducting leads (N-QD-S), which is strongly influenced by the Kondo and superconducting correlations. From the numerical calculation, we find that the renormalized couplings between the leads and the dot in the equilibrium states characterize the peak formation in the nonequilibrium differential conductance. In particular, in the Kondo regime, the enhancement of the Andreev transport via a Kondo resonance occurs in the differential conductance at a finite bias voltage, leading to an anomalous peak whose position is given by the renormalized parameters. In addition to the peak, we show that the energy levels of the Andreev bound states give rise to other peaks in the differential conductance in the strongly correlated N-QD-S system. All these features of the nonequilibrium transport are consistent with those in the recent experimental results [R. S. Deacon {\it et al.}, Phys. Rev. Lett. {\bf 104}, 076805 (2010); Phys. Rev. B {\bf 81}, 12308 (2010)]. We also find that the interplay of the Kondo and superconducting correlations induces an intriguing pinning effect of the Andreev resonances to the Fermi level and its counter position.
Generalized resistance to pruritogen-induced scratching in the C3H/HeJ strain

Previously the effect of the pruritogens, such as histamine and chloroquine, was tested in 11 inbred mouse strains, and this study aimed to identify resistant and sensitive strains, consistent with the observation that underlies the large variability in human populations. In the present study, we used the low responder C3H/HeJ (C3H) and the more sensitive C57BL/6J (C57) strain to find out if resistance and sensitivity to develop pruritus is restricted to only histamine and chloroquine or extends to other known pruritogens as well. We tested five additional commonly known pruritogens. We established dose-response relationships by injecting four concentrations of the pruritogens in the range of 0.3, 1, 3, and ten-fold in the nuchal fold. Then we assessed the scratching behavior for 30 min after injection with an automated custom-designed device based on the bilateral implantation of mini-magnets in the hind paws and on single cages placed within a magnetic coil. We found that the resistance to pruritogens is a general phenotype of the C3H strain and extends to all pruritogens tested, including not only histamine and chloroquine, but also endothelin, trypsin, 5-HT (serotonin), the short peptide SLIGRL, and Lysophosphatidic acid (LPA). C57 was more sensitive to all pruritogens and, in contrast to C3H, dose-response relationships were evident for some of the pruritogens. In general, comparable peak scratch responses were observed for the 0.3-fold concentrations of the pruritogens in C57 whereas C3H required at least the ten-fold concentration and still displayed only between 5 and 33% of the scratch responses observed in C57 for the respective pruritogen. The general resistance to pruritogens and the low level of scratching behavior found in the C3H strain is an interesting trait and represents a model for the study of the heritability of itch. It is accompanied in C3H with a higher sensitivity in assays of nociception.
Teleostean fishes may have developed an efficient Na+ uptake for adaptation to the freshwater system

Understanding Na+ uptake mechanisms in vertebrates has been a research priority since vertebrate ancestors were thought to originate from hyperosmotic marine habitats to the hypoosmotic freshwater system. Given the evolutionary success of osmoregulator teleosts, these freshwater conquerors from the marine habitats are reasonably considered to develop the traits of absorbing Na+ from the Na+-poor circumstances for ionic homeostasis. However, in teleosts, the loss of epithelial Na+ channel (ENaC) has long been a mystery and an issue under debate in the evolution of vertebrates. In this study, we evaluate the idea that energetic efficiency in teleosts may have been improved by selection for ENaC loss and an evolved energy-saving alternative, the Na+/H+ exchangers (NHE3)-mediated Na+ uptake/NH4 + excretion machinery. The present study approaches this question from the lamprey, a pioneer invader of freshwater habitats, initially developed ENaC-mediated Na+ uptake driven by energy-consuming apical H+-ATPase (VHA) in the gills, similar to amphibian skin and external gills. Later, teleosts may have intensified ammonotelism to generate larger NH4 + outward gradients that facilitate NHE3-mediated Na+ uptake against an unfavorable Na+ gradient in freshwater without consuming additional ATP. Therefore, this study provides a fresh starting point for expanding our understanding of vertebrate ion regulation and environmental adaptation within the framework of the energy constraint concept.
Skeletal muscle deficits are associated with worse exercise performance in pediatric pulmonary hypertension

Background Skeletal muscle deficits are associated with worse exercise performance in adults with pulmonary hypertension (PH) but the impact is poorly understood in pediatric PH. Objective To study muscle deficits, physical inactivity, and performance on cardiopulmonary exercise test (CPET) and exercise cardiac magnetic resonance (eCMR) in pediatric PH. Methods Youth 8–18 years participated in a prospective, cross-sectional study including densitometry (DXA) for measurement of leg lean mass Z-score (LLMZ), handheld dynamometer with generation of dominant and non-dominant handgrip Z-scores, Physical Activity Questionnaire (PAQ), CPET, and optional eCMR. CPET parameters were expressed relative to published reference values. CMR protocol included ventricular volumes and indexed systemic flow at rest and just after supine ergometer exercise. Relationships between LLMZ, PAQ score, and exercise performance were assessed by Pearson correlation and multiple linear regression. Results There were 25 participants (13.7 ± 2.8 years, 56% female, 64% PH Group 1, 60% functional class I); 12 (48%) performed both CPET and eCMR. Mean LLMZ (–0.96 ± 1.14) was associated with PAQ score (r = 50, p = 0.01) and with peak oxygen consumption (VO2) (r = 0.74, p = < 0.001), VO2 at anaerobic threshold (r = 0.65, p < 0.001), and peak work rate (r = 0.64, p < 0.01). Higher handgrip Z-scores were associated with better CPET and eCMR performance. On regression analysis, LLMZ and PAQ score were positively associated with peak VO2, while handgrip Z-score and PAQ score were positively associated with peak work rate. Conclusion Muscle mass and strength are positively associated with exercise performance in pediatric PH. Future studies should determine the effect of rehabilitation programs on muscle properties and exercise performance.
Chinese physical fitness standard for campus football players: A pilot study of 765 children aged 9 to 11

Objectives: In 2022, 55 million Chinese children participate in campus football; however, there is no physical fitness standard, making it a priority task to enhance the current national program. This study aimed to explore a pilot method for the development of a reliable physical fitness standard. Methods: This study examined 765 male football players aged 9 to 11 in 2020 and 2022. The anthropometric and physical fitness assessments were conducted in accordance with the Chinese Football Association’s field manuel. Physical fitness tests include sit and reach test, t test, 30 m run test, and vertical jump test. Physical fitness standard was modeled using the generalized additive models for location, scale, and shape (GAMLSS). Data were fitted with appropriate GAMLSS distributions and smoothing term. P-splines were applied to smooth the model’s parameters using the default local maximum likelihood method and link functions. Following diagnostics of fitted models, age-specific centile estimations were computed for physical fitness tests. In addition, players in each age group were categorized according to their body mass index as normal weight or overweight/obese. Welch’s t-test was utilized to compare the group differences in physical fitness testing. The significance level was chosen at p < 0.05. Results: Sit and reach test, t test, 30 m run test, and vertical jump test data were fitted with original Sinh-Arcsinh, Box-Cox power exponential, Box-Cox power exponential, and Box-Cox Cole and Green, respectively. Physical fitness standard for each age group is presented as tabulated centiles (1p, 3p, 5p, 15p, 25p, 50p, 75p, 85p, 95p, 97p, 99p). Overweight/obese campus football players did significantly worse (p < 0.05) on the t test, 30 m run test, and vertical jump test than their normal-weight peers of the same age. Conclusion: This study developed the first physical fitness standard for 9 to 11-year-old campus football players in China. We made three recommendations to Chinese policymakers on sample size, data management, and field procedure for the creation of a national physical fitness standard.
Iron deprivation enhances transcriptional responses to in vitro growth arrest of Mycobacterium tuberculosis

The establishment of Mycobacterium tuberculosis (Mtb) long-term infection in vivo depends on several factors, one of which is the availability of key nutrients such as iron (Fe). The relation between Fe deprivation inside and outside the granuloma, and the capacity of Mtb to accumulate lipids and persist in the absence of growth is not well understood. In this context, current knowledge of how Mtb modifies its lipid composition in response to growth arrest, depending on iron availability, is scarce. To shed light on these matters, in this work we compare genome-wide transcriptomic and lipidomic profiles of Mtb at exponential and stationary growth phases using cultures with glycerol as a carbon source, in the presence or absence of iron. As a result, we found that transcriptomic responses to growth arrest, considered as the transition from exponential to stationary phase, are iron dependent for as many as 714 genes (iron-growth interaction contrast, FDR <0.05), and that, in a majority of these genes, iron deprivation enhances the magnitude of the transcriptional responses to growth arrest in either direction. On the one hand, genes whose upregulation upon growth arrest is enhanced by iron deprivation were enriched in functional terms related to homeostasis of ion metals, and responses to several stressful cues considered cardinal features of the intracellular environment. On the other hand, genes showing negative responses to growth arrest that are stronger in iron-poor medium were enriched in energy production processes (TCA cycle, NADH dehydrogenation and cellular respiration), and key controllers of ribosomal activity shut-down, such as the T/A system mazE6/F6. Despite of these findings, a main component of the cell envelope, lipid phthiocerol dimycocerosate (PDIM), was not detected in the stationary phase regardless of iron availability, suggesting that lipid changes during Mtb adaptation to non-dividing phenotypes appear to be iron-independent. Taken together, our results indicate that environmental iron levels act as a key modulator of the intensity of the transcriptional adaptations that take place in the bacterium upon its transition between dividing and dormant-like phenotypes in vitro.
Neural circuits mediating food cue-reactivity: Toward a new model shaping the interplay of internal and external factors

COPYRIGHT © 2022 Devoto, Coricelli, Paulesu and Zapparoli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Neural circuits mediating food cue-reactivity: Toward a new model shaping the interplay of internal and external factors