Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of the pathological E200K mutation on human prion protein: A computational screening and molecular dynamics approach

The human prion protein gene (PRNP) is mapped to the short arm of chromosome 20 (20pter‐12). Prion disease is associated with mutations in the prion protein‐encoding gene sequence. Earlier studies found that the mutation G127V in the PRNP increases protein stability. In contrast, the mutation E200K, which has the highest mutation rate in the prion protein, causes Creutzfeldt–Jakob disease (CJD) in humans and induces protein aggregation. We aimed to identify the structural mechanisms of E200k and G127V mutations causing CJD. We used a variety of bioinformatic algorithms, including SIFT, PolyPhen, I‐Mutant, PhD‐SNP, and SNP& GO, to predict the association of the E200K mutation with prion disease. MD simulation is performed, and graphs for root mean square deviation, root mean square fluctuation, radius of gyration, DSSP, principal component analysis, porcupine, and free energy landscape are generated to confirm and prove the stability of the wild‐type and mutant protein structures. The protein is analyzed for aggregation, and the results indicate more fluctuations in the protein structure during the simulation owing to the E200K mutation; however, the G127V mutation makes the protein structure stable against aggregation during the simulation.
& Shan, I. (2021). Corridor quality affects net movement, size of dispersers, and population growth in experimental microcosms. Oecologia, 195(2), 547-556.

Corridors are expected to increase species dispersal in fragmented habitats. However, it remains unclear how the quality of corridors influences the dispersal process, and how it interacts with corridor length and width. Here we investigate these factors using a small-scale laboratory system where we track the dispersal of the model organism Collembola Folsomia candida . Using this system, we study the effects of corridor length, width, and quality on the probability of dispersal, net movement, body size of dispersers, and the rate of change in population size after colonization. We show that corridor quality positively affected dispersal probability, net movement, and the rate of change in population size in colonised patches. Moreover, corridor quality significantly affected the size of dispersers, with only larger individuals dispersing through poor quality corridors. The length and width of corridors affected both the rate at which populations increased in colonised patches and the net number of individuals which dispersed, suggesting that these physical properties may be important in maintaining the flow of individuals in space. Our results thus suggest that corridor quality can have an important role in determining not only the probability of dispersal occurs but also the phenotypes of the individuals which disperse, with concomitant effects on the net movement of individuals and the rate of change in population size in the colonised patches.
Tyrosine kinase inhibitors–induced hypothyroidism as a prognostic factor in metastatic renal cell carcinoma: a systematic review and meta-analysis

Li Bo Sichuan University West China Hospital Department of Urology Liang Zhou Sichuan University West China Hospital Department of Urology Yin Tang Sichuan University West China Hospital Department of Urology Yu Liu Sichuan University West China Hospital Department of Urology Kunjie Wang (  wangkj@scu.edu.cn ) Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University https://orcid.org/0000-0001-8289-2791 Hong Li Sichuan University West China Hospital Department of Urology
Correlations of Biomechanical Characteristics with Ball Speed in Penalty Corner Push-In Effect of Strength, Endurance and Concurrent Training on selected Bio-Motor Variables of Middle Distance Runners Journal of Recent Research and Applied Studies

The purpose of the study was to find out the effect of strength, endurance and concurrent training on selected bio-motor variables of middle distance runners. To achieve the purpose of the present study, sixty middle distance runners from affiliated colleges of University of Madras, Chennai, Tamilnadu, India were selected as subjects at random and their ages ranged from 18 to 28 years. The study was formulated as a true random group design, consisting of a pre-test and post-test. Sixty middle distance runners from affiliated colleges of University of Madras, Chennai, Tamilnadu, India was selected as subjects at random and their ages ranged from 18 to 28 years. The subjects (N=60) were randomly assigned to four equal groups of fifteen subjects each. Pre test was conducted for all the subjects on selected bio-motor variables. This initial test scores formed as pre test scores of the subjects. The groups were assigned as Experimental Group I, Experimental Group II, Experimental Group III and Control Group in an equivalent manner. Experimental Group I was exposed to strength training, Experimental Group II was exposed to endurance training, Experimental Group III was exposed to concurrent training and Control Group was not exposed to any experimental training other than their regular daily activities. The duration of experimental period was 12 weeks. After the experimental treatment, all the sixty subjects were tested on their bio-motor variables. This final test scores formed as post test scores of the subjects. The pre test and post test scores were subjected to statistical analysis using Analysis of Covariance (ANCOVA) to find out the significance among the mean differences, whenever the ‘F’ ratio for adjusted test was found to be significant; Scheffe’s post hoc test was used. In all cases 0.05 level of confidence was fixed to test hypotheses. The concurrent training had shown significant improvement in speed and agility than the strength training, endurance training and control groups.
Gender Differences and Achievement at the Advanced Level Chemistry in the General Certificate of Education Examinations in the English Speaking Sub System of Education in Cameroon

Achievement is used as one of the important indices upon which most decisions about the learner is based and it is a complex and multivariate issue with a plethora of evidence associated with determinants of student achievement disparities. The objective of the study was to investigate the influence of gender differences on achievement disparities in Chemistry at the Advanced Level GCE examination in the English Speaking sub system of education in Cameroon. This study adopts a qualitative case study design and makes use of the concurrent procedures of an inquiry strategy of multiple case study research in which the researcher uses a triangulation method of analyzing the GCE results and engaging in an interview with passed Chemistry candidates and Chemistry teachers. The population comprised of 55,786 candidates who wrote the GCE in A/L Chemistry in the English Speaking sub system of education in all the regions of the Republic of Cameroon from 2012 – 2016. The sample of the study consisted of 42,766 candidates who wrote Advanced Level Chemistry from 2012-2016 in five of the ten regions in Cameroon purposefully selected from all coeducational institutions for content analysis of their GCE results and also twenty students and eight teachers purposively selected for interviews. A non- probability design of convenience sampling and purposive sampling technique was used. The instruments for data collection for the study was a self-made Document Analysis Form (DAF), and an interview guide. At the end of data collection, the statistical analysis technique used to test the hypothesis was the independent t-test while the perceptions and opinions of the students and teachers interviewed were analysed thematically in terms of percentages. One research question and one hypothesis guided the study. The research question was answered using mean and percentages while the formulated hypotheses were tested at 0.05 level of significance using the student t-test statistics. The analyses showed that Gender was strongly associated with Chemistry achievement and mean difference was significant (P= <0.05) with male having a mean of 82.046 higher than of the female (40.1230. Based on these findings, it is recommended that Chemistry and Mathematics teachers should team up to ensure integrative learning, transfer and application of knowledge among the females by giving them more attention/time during classes, use of teaching strategies which the female perceive as attainable and compatible with their abilities, preferences, and goals. of
OF DIETARY CHROMIUM, SELENIUM AND VITAMIN C SUPPLEMENTATION TO THE DIET ON REPRODUCTIVE PERFORMANCE AND EGG QUALITY OF LAYING HENS DOKKI-4 UNDER EGYPTIAN SUMMER CONDITION

SUMMARY he study was performed to evaluate the effect of organic chromium (Cr), organic selenium (Se) or vitamin C (vit. C) alone or in combination on reproductive performance, and egg quality of Dokki-4 laying hens under hot summer conditions of Egypt. A total number of 240 hens plus 48 cocks from Dokki-4 strain at 30 weeks of age were randomly selected and distributed into eight groups with 3 replicates ( 10 hens + 1 cock) each. The remaining 24 cocks were also divided into 8 groups of 3 cocks each and housed separately for semen evaluation experiment. Treatments groups were fed a basal diet (control group) or the basal diet supplemented with either 400 µg Cr/kg diet (Cr group), 250 mg of L-ascorpic acid /kg diet (vit. C. group), 0.2 mg Se/kg diet (Se group), 400 µg Cr plus 250 mg of L-ascorpic acid/ kg diet (Cr + vit. C group), 400 µg Cr plus 0.2 mg Se/kg diet ( Cr + Se group), 2 mg Se plus 250 mg L-ascorbic acid/kg diet ( Se + vit. C. group) and 400 µ Cr plus 0.2 mg Se plus 250 mg ascorbic acid /Kg diet (Cr + Se + vit.C group). All groups were put under observation for 12 weeks. Results obtained can be summarized as follows: Supplementation of Cr, Se or vitamin C alone or in combinations significantly increased (P < 0.05) shell thickness, haugh units, albumin and shell to egg weight, sperm motility, ejaculate volume, sperm concentration, total sperm output, total motile sperm, live spermatozoa, semen quality factor and significantly decreased (P < 0.05) dead spermatozoa and seminal malondialdehyde (MDA) as compared with control group. The best result was obtained for layers fed diet containing the combinations of the three supplements (Cr, Se or vitamin C) as compared to other groups. In conclusion, combinations of Cr, Se and vitamin C improved the most reproductive traits and egg quality of Dokki-4 strain under Egyptian hot summer.
Mental health of adolescents in displaced and nondisplaced villages

The present study is an attempt to study the mental health of adolescents living in a displaced village and compare with the mental health of adolescents living in a nondisplaced village. Two hundred and forty-two children in the age group of 13 to 16 years age group studying 8 th , 9 th and 10 th standards constituted the sample. Among the total sample 113 adolescents are from displaced village and 129 adolescents are from nondisplaced village. Mental health inventory is used for data collection. Adolescents of displaced and nondisplaced villages did not differ in any of the components of mental health, except in ‘adequate outlook and goals’. Adolescents of a displaced village had lesser adequate outlook and goals compared to their counterparts in a nondisplaced village. Boys of the displaced village scored significantly lower on adequate outlook and goals one of the asset component, and nervous manifestations one of the liabilities component when compared to boys of nondisplaced village. Girls of displaced and nondisplaced villages did not differ in any of the components of mental health except feelings of inadequacy. Girls of displaced village scored significantly lower on feelings of inadequacy when compared to girls of nondisplaced village indicating the occurrence of this liability more in girls of displaced village.
A Analyzing the Adoption and Cascading Process of OSN-based Gifting Applications: An Empirical Study1

To achieve growth in user base of OSN-based applications, word-of-mouth diffusion mechanisms such as user-to-user invitations are widely used. This paper characterizes the adoption and cascading process of OSN-based applications that grow via user invitations. We analyze a detailed large-scale dataset of a popular Facebook gifting application, iHeart, that contains more than 2 billion entries of user activities generated by 190 million users during a span of 64 weeks. We investigate: (1) how users invite their friends to an OSN-based application, (2) how application adoption of an individual user can be predicted, (3) what factors drive the cascading process of application adoptions, and (4) what are the good predictors of the ultimate cascade sizes. We find that sending or receiving a large number of invitations does not necessarily help to recruit new users to iHeart. We also find that the average success ratio of inviters is the most important feature in predicting an adoption of an individual user, which indicates that the effectiveness of inviters has strong predictive power with respect to application adoption. Based on the lessons learned from our analyses, we build and evaluate learning-based models to predict whether a user will adopt iHeart or not. Our proposed model that utilizes additional activity information of individual users from other similar type of gifting applications can achieve high precision (83%) in predicting adoptions in the target application (i.e., iHeart). We next identify a set of distinctive features that are good predictors of the growth of the application adoptions in terms of final population size. We finally propose a prediction model to infer whether a cascade of application adoption will continue to grow in the future based on observing the initial adoption process. Results show that our proposed model can achieve high precision (over 80%) in predicting large cascades of application adoptions. We believe our work can give an important implication in resource allocation of OSN-based product stakeholders, e.g., via targeted marketing.
Development, Investigation and Comparison of Split Fan Blades’ Performance - A collaboration between Chalmers University of Technology, Pennsylvania State University and Volvo Group

This report contains an investigation of the performance of a fan with split blades, based on the patent “Divided blade rotor” [US 7396208 B1]. The patent was provided by the industrial partner Volvo Group and regards a fan which claimed to allow a higher grade of efficiency. The project started with an investigation of different patents and existing products. A black box and a sub-function diagram were made in order to establish the needs and characteristics the fan needed. From these diagrams, the project group identified seven unique design parameters that were essential for the fan. Since the investigation resulted in parameters, the most suiting method for generating concepts was design of experiment. Although, due to the time limit, the number of parameters had to be reduced to three in order get a reasonable number of concepts. Therefore, the number of generated concepts were eight. The concepts were analysed and evaluated by their fluid dynamics performance, as well as their structural effect. Similar analyses were done on the Reference fan, supplied by Volvo Group. The parameters with the best results were combined with the Reference fan and developed into a final concept, which was analysed through simulations and compared with a similar fan containing solid blades. This made it possible to investigate the split blades’ impact on the efficiency and pressure rise compared to solid blades. The results from the simulation declared the following: • The split blade has a higher working range than a solid blade. • The split blade achieves a larger pressure rise. • The split blade achieves a larger power output compared to the solid blade. • The solid blade achieves a higher efficiency. Hence, the design of the final concept does not have a good aerodynamics structure. There is potential to develop a better concept that could have a better efficiency due to the split blades. The recommendation is to continue the research about the split fan blade. The bachelor’s thesis has been implemented throughout the spring of 2017 as a collaboration between Chalmers University of Technology, Pennsylvania State University and Volvo Group.
beneath from topographic

When a mantle plume rises and impinges on the base of the lithosphere, it expectably produces variations in surface topography. Taking into consideration a realistic mantle rheology, plume ascent rates can reach tens to hundreds of metres per year, whereupon the impingement of the plume head at the base of the lithosphere can be considered as an "impact". Recent numerical experiments based on tectonically realistic formulations for the lithosphere and a representative mantle rheology, have shown that plume-induced undulations exhibit temporal successions of uplift and subsidence at various wavelengths. From spectral (Fourier) analyses of the undulations would appear that two groups of wavelengths (200-400 km and 60-100 km) predominate. Interestingly, a spectral analysis of Europe's topography also reveals two dominant groups. In the present study, we have used a spectral analysis with a wavelet formulation in order to discriminate between tectonically-induced undulations (uni-directional deformation) and plume-induced undulations (omni-directional deformation). The European lithosphere is well-suited for this approach since it has been suggested that two mantle plumes (the Massif Central and the Eifel area) underlie Western Europe, where Alpine compression has folded the lithosphere over several hundreds of kilometres. The wavelet analysis of Europe's surface topography confirms that the energy distribution of the topographic undulations outside the two main volcanic provinces is homogeneous, thus contrasting with the coexistence of both large-scale and medium-scale high-energy features that are obtained for the Massif Central and Eifel areas. Similar signatures are also found beneath the northern Sudetes area. The wavelet approach dedicated to the analysis of plume-related topographic signatures needs, however, detailed theoretical grounds and would probably benefit from two-dimensional analyses. impingement does not detectable large-scale doming – except in the case of a thick cold continental lithosphere – small-scale surface features (basins and uplifts), to regional tectonics.
EIGENFUNCTION EXPANSIONS IN R

The main goal of this paper is to extend in R n a result of Seeley on eigenfunction expansions of real analytic functions on compact manifolds. As a counterpart of an elliptic operator in a compact manifold, we consider in R n a selfadjoint, globally elliptic Shubin type diﬀerential operator with spectrum consisting of a sequence of eigenvalues λ j ,j ∈ N , and a corresponding sequence of eigenfunctions u j ,j ∈ N , forming an orthonormal basis of L 2 ( R n ) . Elements of Schwartz S ( R n ), resp. Gelfand-Shilov S 1 / 2 1 / 2 spaces, are characterized through expansions (cid:2) j a j u j and the estimates of coeﬃcients a j by the power function, resp. exponential function of λ j .
A DC-Coupled High Dynamic Range Biomedical Radar Sensor With Fast-Settling Analog DC Offset Cancelation

One challenge of designing a dc-coupled biomedical radar sensor is dealing with the dc offset voltage presented in its receiver. The undesired dc offset is mainly caused by clutter reflection and hardware imperfection. It may saturate the baseband amplifier and limit the maximum dynamic range that a biomedical radar sensor can achieve. AC-coupling the signal can eliminate dc offset but it will also distort the signal, and thus may not be acceptable for high precision applications. In this paper, a dc-coupled biomedical radar sensor is proposed incorporating an analog dc offset cancelation circuit with fast start-up feature. It can automatically remove any dc offset in the baseband signal and emulates an ac-coupling system. It can also be easily reconfigured into a dc-tracking mode when application requires. When entering this mode, the initial dc offset will be removed, whereas future dc change can be recorded. The proposed solution only uses analog components without requiring any digital signal processing nor software programing. Therefore, compared with the existing digitized dc offset calibration techniques, the proposed method has the advantage of low cost, easy implementation, short delay, and high resolution. The experiment results demonstrated that a wide range of dc offset can be successfully removed from the biomedical radar sensor, and its dynamic range can be maximized. The reconfiguration of the dc-tracking mode has also been tested and verified. Furthermore, the proposed dc offset cancelation circuit has the potential to be easily adopted by other systems that also face the dc offset problem.
Appendix A Data A . 1 Study Context

The research focuses on three developing countries Ethiopia, India (in the states of Andhra Pradesh and Telangana), and Vietnam. According to the Younglives data team, these countries were chosen to reflect a wide range of cultural, economic, geographical, political and social contexts. They face some of the common issues experienced by developing countries, such as high debt burden, post-conflict reconstruction, and adverse environmental conditions such as drought and flood. In the past decade, however, all of these countries have experienced consistent economic growth. Despite the considerable strides towards economic growth, there still remains unresolved challenges of poverty and high levels of social and economic inequality. Ethiopia is a low income country but has reported economic growth averaging around 11 per cent annually since 2003, with the proportion of the population living in poverty falling to around 30 per cent from around 45 per cent ten years previously. Since 2005 Ethiopia has been implementing the Productive Safety Net Programme (PSNP), which helps chronically poor people to withstand shocks by addressing their short-term consumption needs and protecting their assets from further depletion. Ethiopia has a National Plan of Action for Children accompanied by a series of nutrition, health and education strategies. The country has made great strides in increasing primary enrollment through successive Education Sector Development Programmes, although secondary enrollment lags behind and there are significant challenges regarding the quality of education (Pells & Woodhead, 2014). Andhra Pradesh is the fifth-largest state in India. An estimated one in three people in the state live below the poverty line and have been badly hit by inflation and rising food prices, following the global economic crisis. The Government has sought to address these challenges through a series of programmes aimed at improving children’s development and tackling high levels of malnutrition has been introduced. The Right to Education Act was implemented in 2010 and provides free and compulsory education to all children aged six to 14. Its key objectives include monitoring and improving the quality of elementary education; and reducing gaps between social groups and by gender (Pells & Woodhead, 2014). Vietnam has instigated a series of economic reforms, transitioning to a