Miracle-dz/UniFAR-FTUs huggingface dataset:
In-depth analysis of the Sirtuin 5-regulated mouse brain malonylome and succinylome using library-free data-independent acquisitions

Post‐translational modifications (PTMs) dynamically regulate proteins and biological pathways, typically through the combined effects of multiple PTMs. Lysine residues are targeted for various PTMs, including malonylation and succinylation. However, PTMs offer specific challenges to mass spectrometry‐based proteomics during data acquisition and processing. Thus, novel and innovative workflows using data‐independent acquisition (DIA) ensure confident PTM identification, precise site localization, and accurate and robust label‐free quantification. In this study, we present a powerful approach that combines antibody‐based enrichment with comprehensive DIA acquisitions and spectral library‐free data processing using directDIA (Spectronaut). Identical DIA data can be used to generate spectral libraries and comprehensively identify and quantify PTMs, reducing the amount of enriched sample and acquisition time needed, while offering a fully automated workflow. We analyzed brains from wild‐type and Sirtuin 5 (SIRT5)‐knock‐out mice, and discovered and quantified 466 malonylated and 2211 succinylated peptides. SIRT5 regulation remodeled the acylomes by targeting 164 malonylated and 578 succinylated sites. Affected pathways included carbohydrate and lipid metabolisms, synaptic vesicle cycle, and neurodegenerative diseases. We found 48 common SIRT5‐regulated malonylation and succinylation sites, suggesting potential PTM crosstalk. This innovative and efficient workflow offers deeper insights into the mouse brain lysine malonylome and succinylome.
Miniaturized and dual-band metamaterial absorber with fractal Sierpinski structure

We report on the design, characteristics, and measurements of a terahertz (THz) metamaterial absorber (MA) based on fractal Sierpinski curves. By applying the fractal structure as the top resonators array, a more compact unit cell with a size reduction of 42% and dual-frequency operation has been achieved as an advantage over the conventional square-shaped MA. In addition, due to the rotationally symmetric structure, the fractal absorber is polarization insensitive and can perform well at a wide range of incident angles. Both the effective medium theory and the multireflection interference theory have been employed to investigate the underlying physical mechanism of the proposed THz MA, and it is found that the latter theory is not applicable for explaining the absorption mechanism of our investigated structure. The THz MA was measured in the case of 30° oblique incidence under TE polarization, and two absorption peaks have been observed at 0.2 and 0.58 THz with absorptivities of 91% and 92.2%, respectively. A microwave MA based on the same Sierpinski structure has also been demonstrated to validate the performance of the fractal MA at various incident angles, and good agreements between the full-wave simulation and experimental results have been achieved.
The electric dipole moment of the electron: An intuitive explanation for the evasion of Schiff’s theorem

In most experimental searches for the electron electric dipole moment, one searches for a linear Stark effect in a paramagnetic atom or molecule and interprets the result in terms of the electric dipole moment of the unpaired valence electron(s). Schiff’s theorem states that in the limit of nonrelativistic quantum mechanics, there can be no linear Stark effect to first order in the electric dipole moment. Sandars has shown that Schiff’s theorem is not applicable when special relativity is taken into account. We give a heuristic explanation for this relativistic effect, which corrects a widespread misconception in the literature.
Green light analgesia in mice is mediated by visual activation of enkephalinergic neurons in the ventrolateral geniculate nucleus

Green light exposure has been shown to reduce pain in animal models. Here, we report a vision-associated enkephalinergic neural circuit responsible for green light–mediated analgesia. Full-field green light exposure at an intensity of 10 lux produced analgesic effects in healthy mice and in a model of arthrosis. Ablation of cone photoreceptors completely inhibited the analgesic effect, whereas rod ablation only partially reduced pain relief. The analgesic effect was not modulated by the ablation of intrinsically photosensitive retinal ganglion cells (ipRGCs), which are atypical photoreceptors that control various nonvisual effects of light. Inhibition of the retino–ventrolateral geniculate nucleus (vLGN) pathway completely abolished the analgesic effects. Activation of this pathway reduced nociceptive behavioral responses; such activation was blocked by the inhibition of proenkephalin (Penk)–positive neurons in the vLGN (vLGNPenk). Moreover, green light analgesia was prevented by knockdown of Penk in the vLGN or by ablation of vLGNPenk neurons. In addition, activation of the projections from vLGNPenk neurons to the dorsal raphe nucleus (DRN) was sufficient to suppress nociceptive behaviors, whereas its inhibition abolished the green light analgesia. Our findings indicate that cone-dominated retinal inputs mediated green light analgesia through the vLGNPenk-DRN pathway and suggest that this signaling pathway could be exploited for reducing pain. Description Green light–induced analgesia in mice is mediated by a light-activated subpopulation of neurons in the ventrolateral geniculate nucleus. Pain relief gets the green light Pain relief gets the green lightExposure to green light exerts analgesic effects in rodents by activating a subpopulation of neurons in the ventrolateral geniculate nucleus (vLGN). Exposure to green light has been shown to reduce pain sensation in rodents, however, the mechanisms remain to be completely elucidated. Here, Tang et al. performed mechanistic studies in rodents and showed that cone and rod photoreceptor-mediated activation of neurons expressing proenkephalin in the vLGN mediated the analgesic effect of green light by modulating the activity of the dorsal raphe nucleus (DRN). The vLGN-DRN circuit is thus a potential target for reducing pain. ---MM
Graphene FETs with high and low mobilities have universal temperature-dependent properties

We use phenomenological modelling and detailed experimental studies of charge carrier transport to investigate the dependence of the electrical resistivity, ρ, on gate voltage, V g , for a series of monolayer graphene field effect transistors with mobilities, μ, ranging between 5000 and 250 000 cm2 V−1 s−1 at low-temperature. Our measurements over a wide range of temperatures from 4 to 400 K can be fitted by the universal relation μ=4/eδnmax for all devices, where ρmax is the resistivity maximum at the neutrality point and δn is an ‘uncertainty’ in the bipolar carrier density, given by the full width at half maximum of the resistivity peak expressed in terms of carrier density, n. This relation is consistent with thermal broadening of the carrier distribution and the presence of the disordered potential landscape consisting of so-called electron–hole puddles near the Dirac point. To demonstrate its utility, we combine this relation with temperature-dependent linearised Boltzmann transport calculations that include the effect of optical phonon scattering. This approach demonstrates the similarity in the temperature-dependent behaviour of carriers in different types of single layer graphene transistors with widely differing carrier mobilities. It can also account for the relative stability, over a wide temperature range, of the measured carrier mobility of each device.
OF THE RELATIONSHIP BETWEEN PERIODONTITIS AND CARDIOVASCULAR DISEASE by

Objective: It has been proposed that periodontitis and cardiovascular disease are related through a similar underlying inflammation pathway. There has also been suggestion of a genetic etiology connecting the two conditions. Further clarification of this proposed relationship has public health significance as both diseases affect over a quarter of the adult population of the United States. Using data from the Center from Oral Health Research in Appalachia cohort, we examined the relationship between periodontitis and cardiovascular disease. We then tested their association to candidate genetic loci to assess if the genetic loci may explain part of the relationship between the conditions. Methods and Results: Three indicators of periodontitis were developed; a molecular testingbased variable (BANA, n=970) and two probing depth measurements, a liberal approximation that considered missing teeth as missing due to periodontitis (n=973) and a conservative one that did not (n=961). Personal and family history of heart disease and high blood pressure were condensed into a composite score indicative of cardiovascular disease (n=973). Four candidate single nucleotide polymorphisms (SNPs) were identified in the literature as related to both periodontitis and cardiovascular disease: rs10864294, rs4252120, rs1800795, and rs10965215. Regression models were used to test the association between periodontitis and cardiovascular disease indicators and candidate SNPs with and without Thesis Director: John R. Shaffer, PhD
On a two-phase continuous casting Stefan problem with nonlinear flux

We prove the existence of a weak solution for a two-phase continuous casting Stefan problem with a general monotone nonlinear cooling condition. We establish a sufficient condition for stability, which yields uniqueness and comparison results for the evolutionary and the steady- state solutions. We also discuss the asymptotic behaviour as t←∞ of the corresponding temperatures and enthalpies.
Accumulator three phase converter

—The paper presents description of design of a voltage converter and a 3-phase inverter with smart LCD controller. The LCD control terminal communicates via proprietary CAN interface. The final converter can supply a 3-phase output voltage with a selectable waveform, but primarily a harmonic sinusoidal (user configurable via terminal). The inverter will have an adjustable voltage (sinusoidal amplitude) in a certain range which is configured by user via control terminal also. It provides the possibility of a small correction of the output frequency and phase shift so that it can generate, for example, a two-phase 120 V grid and others.
Effects of surface lamination process parameters on medium density fiberboard (MDF) properties

Medium density fiberboard (MDF) is widely utilized in furniture production. Most MDF in such applications has a surface laminate layer. The lamination process improves the physical and mechanical properties of the boards. The temperature, press time, and pressure values applied during the lamination process affect such properties. In this work, the lamination process was carried out using a constant temperature (180 °C), four different press times (18, 20, 22, and 24 s), and three different pressures (25, 30, and 35 kg/cm2). The raw weight of the decor paper was 90 g/m2 and UF and MF glues were used in its production. The properties of the laminated panels were then determined for each variation. In general, the water absorption and thickness swelling properties were improved at the lower pressure and higher press times. The internal bonding strength exhibited a linear change at different press times depending on increasing pressure values, whereas the changes in the bending strength and modulus of elasticity in bending were not statistically significant. It was concluded that the BS increased with rising pressure in the short-term lamination process and that the effect of the pressure on the BS declined with increasing press time.
An assessment of advanced DC-link based reversing voltage type multilevel inverter topologies

In this paper, advanced DC-Link (DCL) based reversing voltage type Multilevel Inverter (MLI) topologies by compensating the difficulties in the conventional MLIs are reviewed. These topologies consist of less switching components and driver circuits when compared with conventional MLIs predominantly in higher levels. Consequently, installation area, total cost and hardware difficulties are reduced by increasing the voltage levels. The unipolar based Pulse Width Modulation Schemes (PWMS) will improve DCL inverters performance. This paper presents unipolar Multi-Reference (MR) based sine and space vector PWMS with single triangular carrier wave for generating required levels in output voltage. Comparison between UMR sine and space vector PWMS for DCL inverter topologies is presented in terms of Fundamental Output Voltage (FOV) and Total Harmonic Distortion (THD). The research tries to establish the survey analysis for single-phase 7-level DCL based reversing voltage type MLI topologies with UMR based sine and space vector PWMs. Finally, to confirm the feasibility of proposed DCL-MLIs in terms of FOV and THD the simulation results are incorporated. Further, the prototype model is developed for single-phase 7-level DCL inverter with Field Programmable Gate Array (FPGA) based UMR sine and space vector PWMS to authenticate simulation results. The efficiency of the proposed cascaded MLI achieves the value of 99.003%.
Lie groups and twistor spaces

On considere un espace symetrique de Riemann simplement connexe M, la connexion de Levi-Civita ⊇ et le fibre torseur metrique #7B-F(M)⊆J~(M) dont les fibres #7B-F x (M) pour x∈M est constitue de structures complexes orthogonales
On the Hochschild Cohomology of Triangular Algebras

Abstract In order to study the Hochschild cohomology of an n-triangular algebra 𝒯 n , we construct a spectral sequence, whose terms are parametrized by the length of the trajectories of the quiver associated with 𝒯 n , and which converges to the Hochschild cohomology of 𝒯 n . We describe explicitly its components and its differentials which are sums of cup products. In case n = 3 we study some properties of the differential at level 2. We give some examples of use of the spectral sequence and recover formulas for the dimension of the cohomology groups of particular cases of triangular algebras.
Superclusters and pencil-beam surveys - The origin of large-scale periodicity

It is shown that the apparent about 130/h Mpc periodic distribution of galaxies recently observed in narrow pencil-beam surveys originates in known large-scale superclusters. The superclusters, covering the high-latitude sky to z below 0.08, show the same peaks that appear in the narrow-beam survey. These results suggest a network structure of large (about 100/h Mpc) supercluster surfaces (walls) surrounding low-density regions. The apparent periodicity is expected to diminish when averaged over different directions. 17 refs.
Harmonic‐tuned high‐efficiency GaN power amplifier with precise AM‐AM and AM‐PM characteristics

An optimal balance between high efficiency and high linearity is one of the main performance metrics of modern base stations to handle the deep compression of the power amplifier (PA) module. In principle, the plethora of amplitude‐to‐amplitude (AM‐AM) and amplitude‐to‐phase (AM‐PM) distortions are issues worth exploring. Therefore, this paper presents a linearized harmonic‐tuned PA that operates at 2.4 GHz. The presented PA utilizes a compact input matching network (IMN) and output MN (OMN) with shunt‐connected tunable resonant circuits augmented by the stabilization network, whose presence greatly reduces the transistor parasitics and high‐order effects. Hence, a joint embodiment of each other gives optimal fundamental impedance matching alongside harmonic terminations and precise AM/PM waveform properties. The measurement results have shown that the fabricated PA exhibits peak saturated output power of 40.9 dBm and peak drain efficiency (DE) of 67%. In addition, the AM‐AM and AM‐PM curves under continuous‐wave excitation yield a gain flatness of 0.5 dB over a 37.5 dBm power range and ±3.5° phase distortion, respectively, when the input power level is swept up to the saturation level of 40 dBm. When driven with a 5 MHz 64‐QAM OFDM signal and 6.9 dB power back‐off, the manufactured PA meets the adjacent channel leakage ratio specification of −30 dBc at an average output power of 34.5 dBm.
The inhibitory effect of dextranases from Bacillus velezensis and Pseudomonas stutzeri on Streptococcus mutans biofilm

Background and Objectives: Dental caries is a breakdown of the teeth enamel due to harmful bacteria, lack of oral hygiene, and sugar consumption. The acid-producing bacterium Streptococcus mutans is the leading cause of dental caries. Dextranase is an enzyme that can degrade dextran to low molecular weight fractions, which have many therapeutic and industrial applications. The purpose of the present study was to isolate a novel dextranase-producing bacteria from a source (molasses). The cell-free extracts containing dextranases were tested as antibiofilm agents. Materials and Methods: Dextranase-producing bacteria were identified using phenotypic and genotypic methods such as 16S rRNA gene sequencing and enzymatic characterization. Results: The highest six dextranase-producing bacterial isolates were Bacillus species. The best conditions for dextranase productivity were obtained after 72 hours of culture time at pH 7. The addition of glucose to the medium enhanced the production of the enzymes. The cell-free extract of the six most active isolates showed remarkable activity against biofilm formation by Streptococcus mutans ATCC 25175. The highest inhibition activities reached 60% and 80% for Bacillus velezensis and Pseudomonas stutzeri, respectively. Conclusion: Therefore, our study added to the current dextranase-producing bacteria with potential as a source of dextranases.
Exchange bias in a ferromagnetic semiconductor induced by a ferromagnetic metal: Fe/(Ga,Mn)As bilayer films studied by XMCD measurements and SQUID magnetometry

We demonstrate an exchange bias in (Ga,Mn)As induced by antiferromagnetic coupling to a thin overlayer of Fe. Bias fields of up to 240 Oe are observed. Using element-specific x-ray magnetic circular dichroism measurements, we distinguish a strongly exchange-coupled (Ga,Mn)As interface layer in addition to the biased bulk of the (Ga,Mn)As film. The interface layer remains polarized at room temperature.
SMILE for Hyperopia With and Without Astigmatism: Results of a Prospective Multicenter 12-Month Study.

PURPOSE To investigate the safety and effectiveness of small incision lenticule extraction (SMILE) in patients who have hyperopia with or without astigmatism. METHODS This was a prospective multicenter trial including 374 eyes of 199 patients treated by SMILE for hyperopia using the VisuMax femtosecond laser (Carl Zeiss Meditec AG). Inclusion criteria were sphere up to +6.00 diopters (D), cylinder up to 5.00 D, and maximum hyperopic meridian up to +7.00 D, with preoperative corrected distance visual acuity (CDVA) of 20/25 or better. The optical zone was 6.3 mm with a transition zone of 2 mm. The minimum lenticule thickness was set at 25 µm in the center and at 10 µm at the edge. Patients were examined at 1 day, 1 week, and 1, 3, 6, 9, and 12 months after surgery. Standard refractive surgery outcomes analysis was performed. RESULTS The preoperative spherical equivalent was +3.20 ± 1.48 D (range: +0.25 to +6.50 D). At the 12-month follow-up visit, 81% of eyes treated were within ±0.50 D and 93% of eyes were within ±1.00 D of intended correction. A total of 1.2% of eyes lost two or more lines of CDVA at the 12-month follow-up visit, and 83% were at least 20/20, corresponding to a safety index of 1.005 at 12 months. Of the 219 eyes with plano target, 68.8% had an uncorrected distance visual acuity of 20/20 or better and 88% were at least 20/25 uncorrected at 12 months. There were no statistically significant changes in contrast sensitivity. CONCLUSIONS SMILE was found to be an effective treatment method for the correction of compound hyperopic astigmatism, demonstrating a high level of efficacy, predictability, safety, and stability. [J Refract Surg. 2022;38(12):760-769. ].
Nonautonomous spatiotemporal solitons in inhomogeneous nonlinear media with linear and nonlinear gain/loss and different distributed diffraction/dispersion

We analytically derive nonautonomous spatiotemporal soliton solutions of the (3 + 1)-dimensional inhomogeneous nonlinear Schrödinger equation with linear and nonlinear gain/loss and different distributed diffraction/dispersion from two kinds of variable transformation connected with a solvable differential equation. Diffraction/dispersion and nonlinearity play important roles in the evolutional characteristics such as amplitude, width, time shift, linear and nonlinear chirp phase, phase offset and phase shift. Diffraction and dispersion management of spatiotemporal solitons with and without nonlinear chirp factor is discussed in a decreasing diffraction/dispersion fiber with exponential, hyperbolic, logarithmic, Gaussian and linear profiles and a periodic modulated system. In a decreasing diffraction/dispersion fiber with exponential profile, the nonlinear chirp factor affects the trace of propagation and the amplitude of the soliton, while the nonlinear chirp factor only influences the amplitude of the soliton in other media. Moreover, we discuss the impact of nonlinear chirp phase on the total phase of spatiotemporal bright and dark solitons.
Convergence of Cascade Algorithms in Sobolev Spaces Associated with Multivariate Refinement Equations

Abstract This paper is concerned with multivariate inhomogeneous refinement equations written in the form ϕ(x) = ∑α ∈ Z s a(α)ϕ (Mx − α) + g(x), x ∈ R s, where ϕ is the unknown function defined on the s-dimentional Euclidean space R s, g is a given compactly supported function on R s, a is a finitely supported sequence on Z s, and M is an s × s dilation matrix with m = |det M|. Let ϕ0 be an initial function in the Sobolev space Wk2( R s). For n = 1, 2,…, define ϕn(x) = ∑α ∈ Z s a(α)ϕn − 1(Mx − α) + g(x), x ∈ R s. In this paper, we give a characterization for the strong convergence in the Sobolev space Wk2( R s)(k ∈ N ) of the cascade sequence (ϕn)n ∈ N for the case in which M is isotropic.
Sensitivity analysis of discrete filtering and smoothing algorithms

Abstract : Two problems which occur when filtering or smoothing methods are applied to an actual problem are the choice of the prior statistics and the choice of a mathematical model for the system. The model must be complete enough for an adequate description of the system and also sufficiently simple such that the resulting algorithms are computationally feasible. A major tool in both analyzing the effects of these choices and in making the best choice is a sensitivity analysis of the algorithms required in the solution of the filtering and smoothing problems. This investigation presents a complete and definitive sensitivity analysis of the discrete smoothing problem. Algorithms are developed for matrix sensitivity functions for both large and differential errors. Two examples are presented to illustrate the use of the given algorithms: a linearized version for the in-track motion of a satellite traveling in a circular orbit, and a simplified version of an error model of a long term inertial navigation system which might be used for marine application. (Author)
Safety of apixaban and rivaroxaban compared to warfarin after cardiac surgery

Direct oral anticoagulants (DOACs) are frequently prescribed for the management of atrial fibrillation and venous thrombosis. There is a lack of published data on the utilization of DOACs in individuals who have undergone recent cardiac surgery. The purpose of this study was to evaluate the safety and efficacy of apixaban and rivaroxaban compared to warfarin in patients postcardiac surgery.