Miracle-dz/UniFAR-FTUs huggingface dataset:
Changes in bicarbonate-extractable phosphorus over time when P fertiliser was withheld or reapplied to pasture soils

Field studies were established on 9 different soil types used for pasture production in the high rainfall zones of southern Victoria. Sites were selected to represent a range of phosphorus (P) buffering capacities (PBC) and were analysed for a series of chemical and physical properties before receiving P fertiliser treatments. A single application of P fertiliser in the form of triple superphosphate (TSP), single superphosphate (SSP), or TSP and lime (5 t/ha) was applied at amounts ranging from 0 to 280 kg P/ha at the start of the experiment, whilst treatments of 35 and 70 kg P/ha were reapplied at 6-monthly intervals. Soils were analysed for bicarbonate-extractable P concentration, using both the Olsen P and Colwell P methods, 6, 12, 18, 24, and 30 months after P fertiliser was applied. A strong positive linear relationship existed at all sites and time periods between the amounts of P applied as a single application and both the Olsen P and Colwell P concentrations. The slopes of these relationships measured the change in extractable P concentration per unit of P applied (ΔEP) and the rate of decline in ΔEP values represented the decline in the effectiveness of the P fertiliser with increasing time from application. The decline in these ΔEP values varied with soil type. The ΔEP values of some low to moderate P buffered soils remained 2–3 times higher compared with the most highly buffered soils, after 30 months. Despite this, the decline in ΔEP values between 6 and 30 months was difficult to predict using a single soil property. Multiple linear regressions involving a measure of PBC and either organic carbon or exchangeable hydrogen were useful methods of predicting the decline in ΔEP values across the 9 field sites examined in this study. In general, the reapplication of P fertiliser every 6 months resulted in significantly higher extractable P concentrations compared with the same rates applied in a single application, across all sites and rates of P applied. The application of SSP, TSP, and TSP and lime had little impact on ΔEP values 18–30 months after treatments were applied.
Accounting for herbaceous communities in process‐based models will advance our understanding of “grassy” ecosystems

Grassland and other herbaceous communities cover significant portions of Earth's terrestrial surface and provide many critical services, such as carbon sequestration, wildlife habitat, and food production. Forecasts of global change impacts on these services will require predictive tools, such as process‐based dynamic vegetation models. Yet, model representation of herbaceous communities and ecosystems lags substantially behind that of tree communities and forests. The limited representation of herbaceous communities within models arises from two important knowledge gaps: first, our empirical understanding of the principles governing herbaceous vegetation dynamics is either incomplete or does not provide mechanistic information necessary to drive herbaceous community processes with models; second, current model structure and parameterization of grass and other herbaceous plant functional types limits the ability of models to predict outcomes of competition and growth for herbaceous vegetation. In this review, we provide direction for addressing these gaps by: (1) presenting a brief history of how vegetation dynamics have been developed and incorporated into earth system models, (2) reporting on a model simulation activity to evaluate current model capability to represent herbaceous vegetation dynamics and ecosystem function, and (3) detailing several ecological properties and phenomena that should be a focus for both empiricists and modelers to improve representation of herbaceous vegetation in models. Together, empiricists and modelers can improve representation of herbaceous ecosystem processes within models. In so doing, we will greatly enhance our ability to forecast future states of the earth system, which is of high importance given the rapid rate of environmental change on our planet.
Clopidogrel-Related High Residual Platelet Reactivity Associated with Estimated Glomerular Filtration Rate in Patients with Acute Ischemic Stroke

Introduction: There are few studies on the relationship between the occurrence of clopidogrel-related high residual platelet reactivity (HRPR) and estimated glomerular filtration rate (eGFR) at admission in patients with ischemic stroke. The aim of this study was to investigate the possible relationship between the two. Methods: Patients who were hospitalized and diagnosed with acute ischemic stroke were recruited from July 1, 2017, to June 30, 2018, at Shanghai TCM-Integrated Hospital. Renal function was measured within 24 h of enrollment and eGFR was calculated. Patients were tested for platelet reactivity using the VerifyNow system after 7 days of antiplatelet therapy with clopidogrel 75 mg/d alone, and patients with P2Y12 reaction unit values ≥230 were diagnosed with HRPR. The association between HRPR and eGFR was analyzed. Results: A total of 274 patients were enrolled in the study, of whom 91 (33.21%) had HRPR. Multivariate logistic regression analysis suggested that an increased risk of HRPR was independently associated with female sex and reduced eGFR (female sex: OR = 2.24, 95% CI: 1.26–3.99, p = 0.006; mild chronic kidney disease [CKD]: OR = 2.95, 95% CI: 1.47–5.93, p = 0.002; moderate CKD: OR = 3.07, 95% CI: 1.08–8.75, p = 0.04). Conclusion: Decreased eGFR is an independent risk factor for the occurrence of HRPR in patients with ischemic stroke.
Multivariate approach to change detection from fraction images

Detection of changes in remotely sensed digital images acquired on different dates are commonly highly influenced by radiometric differences and registration problems. Using fraction images obtained from the linear model of spectral mixing, the radiometric problems can be minimized and interpretation of changes in land cover is simplified. This note explores an algorithm for detecting changes between fraction images, which provides a probabilistic threshold, from which pixels that have undergone change can be identified and classified. The technique requires multivariate normality for the differences of fractions and is based on the fact that the contours of constant density are defined by χ2 values, according the choice of probability level. To include spatial information, morphological operations were performed on the binary images created by the algorithm. Results obtained using synthetic images with high noise levels showed kappa values above 0.87 and a detection rate of approximately 80%, when a low level of significance and morphological filters were used. The experiment using a real pair of images (Landsat-TM), in turn, has successfully identified mining areas and deforestation regions.
Comparative evaluation of a surface‐based respiratory monitoring system against a pressure sensor for 4DCT image reconstruction in phantoms

Abstract Four‐dimensional computed tomography (4DCT), which relies on breathing‐induced motion, requires realistic surrogate information of breathing variations to reconstruct the tumor trajectory and motion variability of normal tissues accurately. Therefore, the SimRT surface‐guided respiratory monitoring system has been installed on a Siemens CT scanner. This work evaluated the temporal and spatial accuracy of SimRT versus our commonly used pressure sensor, AZ‐733 V. A dynamic thorax phantom was used to reproduce regular and irregular breathing patterns acquired by SimRT and Anzai. Various parameters of the recorded breathing patterns, including mean absolute deviations (MAD), Pearson correlations (PC), and tagging precision, were investigated and compared to ground‐truth. Furthermore, 4DCT reconstructions were analyzed to assess the volume discrepancy, shape deformation and tumor trajectory. Compared to the ground‐truth, SimRT more precisely reproduced the breathing patterns with a MAD range of 0.37 ± 0.27 and 0.92 ± 1.02 mm versus Anzai with 1.75 ± 1.54 and 5.85 ± 3.61 mm for regular and irregular breathing patterns, respectively. Additionally, SimRT provided a more robust PC of 0.994 ± 0.009 and 0.936 ± 0.062 for all investigated breathing patterns. Further, the peak and valley recognition were found to be more accurate and stable using SimRT. The comparison of tumor trajectories revealed discrepancies up to 7.2 and 2.3 mm for Anzai and SimRT, respectively. Moreover, volume discrepancies up to 1.71 ± 1.62% and 1.24 ± 2.02% were found for both Anzai and SimRT, respectively. SimRT was validated across various breathing patterns and showed a more precise and stable breathing tracking, (i) independent of the amplitude and period, (ii) and without placing any physical devices on the patient's body. These findings resulted in a more accurate temporal and spatial accuracy, thus leading to a more realistic 4DCT reconstruction and breathing‐adapted treatment planning.
Antarctic Peninsula mesoscale cyclone variability and climatic impacts influenced by the SAM

The frequency of mesoscale cyclones in the Western Antarctic Peninsula (WAP) region during 1991–94 is correlated with the Southern Hemisphere Annular Mode (SAM) index, most strongly during winter and spring. Also, during periods of positive SAM index polarity there is a shift in the storm tracks to favor more east‐bound trajectories, consistent with strengthening of circumpolar westerlies. The presence of mesoscale cyclones is associated with positive near‐surface‐air temperature anomalies in the WAP region year‐round, largest during winter.
Soil respiration, carbon and nitrogen leaching, and nitrogen availability in response to harvest intensity and competing vegetation control in Douglas-fir (Pseudotsuga menziesii) forests of the Pacific Northwest

approved: _____________________________________________________ Stephen H. Schoenholtz Management practices following forest harvest can affect long-term soil productivity through alteration of soil carbon (C) and nitrogen (N) pools, but processes contributing to change are poorly understood. I assessed effects of three levels of logging-debris retention in combination with initial or annual applications of competing vegetation control (CVC) following forest harvesting on soil C flux, N leaching, foliar N of planted Douglas-fir, and changes in soil N and C pools for two years at two sites with contrasting soil properties. Soil C flux was lower when heavy amounts of logging debris were retained, due largely to lower bulk soil and microbial respiration as there was no difference in dissolved organic C (DOC) flux among logging-debris treatments. Increased soil C when heavy amounts of logging debris were retained at the site with lower initial soil C reflected the lower C flux, but soil C was increased at both sites when logging debris was removed, likely due to greater decomposition of belowground organic matter (OM). There was no difference in DOC leaching or soil C between CVC
ENPP1 downregulation and FGF23 upregulation in growth‐related calcification of the tibial tuberosity in rats

During tibial tuberosity growth, superficial and deep portions can be observed; however, the deep portion is not observed after the growth period, as it develops into bone tissues. Calcification in vivo is known to be constitutively suppressed by ectonucleotide pyrophosphatase/phosphodiesterase‐1 (ENPP1) but promoted by tissue‐nonspecific alkaline phosphatase (TNAP). FGF23 promotes calcification of enthesis. Gene expression of FGF23 increased rapidly at 13W in this study. Therefore, the tibial tuberosity is speculated to develop via Enpp1 downregulation and Tnap upregulation; however, the understanding of these processes remains unclear. Hence, in the present study, we aimed to explore the age‐related structural changes and underlying gene expression changes in the tibial tuberosity of rats. Male Wistar rats were divided into three groups (3‐, 7‐, and 13‐week‐old; eight each). The tibial tuberosity superficial and deep portions were clearly observed in 3‐ and 7‐week‐old rats, but the presence of the deep portion was not confirmed in 13‐week‐old rats. The extracellular matrix of hypertrophic chondrocytes was calcified. Furthermore, the Enpp1 expression was the highest in 3‐week‐old rats and decreased with growth. The TNAP expression did not differ significantly among the groups. The deep portion area was significantly lower in 3‐week‐old rats than in 7‐week‐old rats. Generally, the extracellular matrix of the immature chondrocytes is not calcified. Therefore, we speculated that the cartilaginous tibial tuberosity calcifies and ossifies with growth. The Enpp1 expression decreased with growth, whereas the Tnap expression remained unchanged. Thus, we surmise that the tibial tuberosity calcifies with growth and that this process involves Enpp1 downregulation and FGF23 upregulation. As Osgood–Schlatter disease is closely related to the calcification of the tibial tuberosity, these findings may help clarify the pathogenesis of this disease.
Intraventricular Lavage vs External Ventricular Drainage for Intraventricular Hemorrhage

Key Points Question Is ventricular lavage a safe and effective treatment of intraventricular hemorrhage compared with passive drainage? Findings This randomized clinical trial of 21 patients comparing intraventricular lavage with standard drainage treatment found significantly higher risks of SAEs and catheter occlusions in the intervention group. The trial was terminated early, as recommended by an independent data safety monitoring board, due to safety concerns at preplanned interim analysis of 20 patients. Meaning These findings suggest that caution should be taken when using intraventricular lavage for IVH treatment and technology adaptations should be implemented to mitigate future adverse events.
Predictive and Associated Factors of Burnout in Nursing Faculty: An Integrative Review.

BACKGROUND Nurse educators are at high risk of experiencing burnout, resulting in high numbers of vacant faculty positions. PURPOSE The aims of this integrative review were to review the prevalence of measurable dimensions of professional burnout and discuss the predictive and associated factors of burnout and intent to leave nursing academia. APPROACH This review used the Whittemore and Knafl integrative review methodology to perform a structured search of 4 electronic databases (CINAHL, ERIC, EMBASE, and PubMed). OUTCOMES Nine empirical research studies measured 5 identifiable features of burnout in nursing educators: emotional exhaustion, depersonalization, lack of accomplishment, compassion satisfaction, and secondary traumatic stress. Five predictors of intent to leave nursing academia were identified: demographics, health status, salary, workload, and work-life imbalance. CONCLUSIONS The highest contributing factor to burnout and intent to leave nursing academia is high workload levels and lack of work-life balance. Nursing faculty report moderate to high levels of all dimensions of professional burnout.
Stearoyl‐CoA desaturase 1 inhibition impairs triacylglycerol accumulation and lipid droplet formation in colorectal cancer cells

Increases in fatty acid (FA) biosynthesis meet the higher lipid demand by intensely proliferating cancer cells and promoting their progression. Stearoyl‐CoA desaturase 1 (SCD1) is the key enzyme in FA biosynthesis, converting saturated FA (SFA) into monounsaturated FA (MUFA). Increases in the MUFA/SFA ratio and SCD1 expression have been observed in cancers of various origins and correlate with their aggressiveness. However, much is still unknown about the SCD1‐dependent molecular mechanisms that promote specific changes in metabolic pathways of cancer cells. The present study investigated the involvement of SCD1 in shaping glucose and lipid metabolism in colorectal cancer (CRC) cells. Excess FAs that derive from de novo lipogenesis are stored in organelles, called lipid droplets (LDs), mainly in the form of triacylglycerol (TAG) and cholesteryl esters. LD accumulation is associated with key features of cancer development and progression. Consistent with our findings, the pharmacological inhibition of SCD1 activity affects CRC cell viability and impairs TAG accumulation and LD formation in these cells through the activation of lipolytic and lipophagic pathways. We showed that SCD1 suppression affects crucial lipogenic processes that promote lipid accumulation in CRC cells but in a sterol regulatory element‐binding protein 1‐independent manner. We propose that adenosine monophosphate‐activated protein kinase contributes to these changes through the activation of lipolysis and inhibition of TAG synthesis. We also provide evidence of the involvement of SCD1 in the regulation of glucose uptake and utilization in CRC cells. These findings underscore the importance of SCD1 in regulating cellular processes that promote cancer development and progression.
CAR-T Therapy Targets Extra Domain B of Fibronectin Positive Solid Tumor Cells

ABSTRACT Background CAR-T cell immunotherapy has achieved remarkable success in malignant B-cell malignancies, but progress in solid tumors is slow, and one of the key reasons is the lack of ideal targets. Cancer-specific extra domain B of fibronectin (EDB-FN) is widely upregulated in solid tumors and expressed at low levels in normal tissues. Many imaging and targeted cancer therapies based on EDB-FN targets have been developed and tested in clinical trials, making EDB-FN an ideal target for immunotherapy. Methods We constructed two EDB-FN-targeted CAR-Ts based on the peptide APT0 and the single-chain antibody CGS2 in a lentiviral infection manner for the first time. Luciferase cytotoxicity assay to assess CAR-T killing of tumor cells. An enzyme-linked immunosorbent assay was used to detect the release of the cytokine IFN-γ. Fluorescence imaging to evaluate the dynamics of CAR-T cell and tumor cell coculture. Knockdown assays were used to validate the target specificity of CAR-T cells. Results In this research, two CAR-Ts targeting EDB-FN, APT0 CAR-T, and CGS2 CAR-T, were constructed. In vitro, both CAR-T cells produced broad-spectrum killing of multiple EDB-FN-positive solid tumor cell lines and were accompanied by cytokine IFN-γ release. Regarding safety, the two CAR-T cells did not affect T cells’ normal growth and proliferation and were not toxic to HEK-293T human embryonic kidney epithelial cells. Conclusion APT0 CAR-T and CGS2 CAR-T cells are two new CAR-Ts targeting EDB-FN. Both CAR-T cells can successfully identify and specifically kill various EDB-FN-positive solid tumor cells with potential clinical applications.
Identification of a functional peptide of a probiotic bacterium-derived protein for the sustained effect on preventing colitis

ABSTRACT Several probiotic-derived factors have been identified as effectors of probiotics for exerting beneficial effects on the host. However, there is a paucity of studies to elucidate mechanisms of their functions. p40, a secretory protein, is originally isolated from a probiotic bacterium, Lactobacillus rhamnosus GG. Thus, this study aimed to apply structure-functional analysis to define the functional peptide of p40 that modulates the epigenetic program in intestinal epithelial cells for sustained prevention of colitis. In silico analysis revealed that p40 is composed of a signal peptide (1–28 residues) followed by a coiled-coil domain with uncharacterized function on the N-terminus, a linker region, and a β-sheet domain with high homology to CHAP on the C-terminus. Based on the p40 three-dimensional structure model, two recombinant p40 peptides were generated, p40N120 (28–120 residues) and p40N180 (28–180 residues) that contain first two and first three coiled coils, respectively. Compared to full-length p40 (p40F) and p40N180, p40N120 showed similar or higher effects on up-regulating expression of Setd1b (encoding a methyltransferase), promoting mono- and trimethylation of histone 3 on lysine 4 (H3K4me1/3), and enhancing Tgfb gene expression and protein production that leads to SMAD2 phosphorylation in human colonoids and a mouse colonic epithelial cell line. Furthermore, supplementation with p40F and p40N120 in early life increased H3K4me1, Tgfb expression and differentiation of regulatory T cells (Tregs) in the colon, and mitigated disruption of epithelial barrier and inflammation induced by DSS in adult mice. This study reveals the structural feature of p40 and identifies a functional peptide of p40 that could maintain intestinal homeostasis.
Modelling Paleoindian dispersals

It is reasonable to expect that the global dispersal of modern humans was influenced by habitat variation in space and time; but many simulation models average such variation into a single, homogeneous surface across which the dispersal process is modelled. We present a demographic simulation model in which rates of spatial range expansion can be modified by local habitat values. The broad-scale vegetation cover of North America during the late last glacial is reconstructed and mapped at thousand-year intervals, 13,000-10,000 radiocarbon years BP. Results of the simulation of human dispersal into North America during the late last glacial are presented; output appears to match observed variation in occupancy of habitats during this period (as assessed from discard rates of diagnostic artefacts), if we assume that intrinsic population growth rates were fairly high and that local population densities varied as a function of environmental carrying capacity. Finally, a number of issues are raised relating to present limitations and possible future extensions of the simulation model.
Oxygen ionization rates at Mars and Venus: Relative contributions of impact ionization and charge exchange

Oxygen ion production rates above the ionopauses of Venus and Mars are calculated for photoionization, charge exchange, and solar wind electron impact ionization processes. The latter two require the use of the Spreiter and Stahara (1980) gas dynamic model to estimate magnetosheath velocities, densities, and temperatures. The results indicate that impact ionization is the dominant mechanism for the production of O+ ions at both Venus and Mars. This finding might explain both the high ion escape rates measured by Phobos 2 and the greater mass loading rate inferred for Venus from the bow shock positions.
Marginal mixing theories

Abstract Mixing near the sloping boundaries of oceans or lakes may be a significant mechanism of diapycnal transport. The basic physics of this is reviewed, with emphasis on the reduction of the effectiveness of the process due to both reduced stratification and the restratifying secondary circulation driven by buoyancy forces. This re stratification is shown to reduce the effectiveness of intermittent mixing events as well as steady mixing. It is argued that for boundary mixing to be effective in the abyssal ocean it must extend sufficiently far from the boundary that the stratification can be maintained; this may be true for breaking bottom‐reflected internal waves. The alongslope flow implied by steady‐state boundary mixing theories is downwelling‐favourable and has a magnitude related to the thickness and other properties of the boundary layer. Mixing near a boundary may thus tend to drive a downwelling‐favourable mean circulation in the interior. If the interior circulation is imposed by other forces.
Leiomyosarcoma of the rectum: A systematic review of recent literature

Leiomyosarcomas (LMSs) are rare tumors originating from the muscular layer. We performed a literature review of cases of confirmed rectal leiomyosarcomas (rLMSs) to clarify the history of such an infrequent tumor arising at such an uncommon location. In this research local recurrence was related to poorly differentiated rLMS and no other association between recurrence and any criteria was found. Concerning overall survival (OS), rLMS patients developing recurrence presented shorter longevity compared with the group without.