Miracle-dz/UniFAR-FTUs huggingface dataset:
Fukushima and the Future of Nuclear Energy in Japan: The Need for a Robust Social Contract

The Fukushima accident in March 2011 calls for the reassessment of the nuclear regime in Japan, especially as regards to public safety. The serious accident that occurred in Fukushima Dai-ichi nuclear power plant caused by the 11 March earthquake (M. 8.9) has been a hard and costly lesson for Japan’s obscure and corrupted nuclear energy regime, the so-called ‘nuclear village’, that grew during the long era of rapid economic growth that had little regard for public safety; crucially missing in this past policy to promote nuclear energy was the proper social contract between the State and society. In a highly-industrialised democracy, the accident’s social and economic impact weighs heavily on the decision-makers, but Japan needs to re-think nuclear energy first from the perspective of rebuilding and then by honouring the public’s trust in the State.
At the crossroads of logics: Automating newswork with artificial intelligence—(Re)defining journalistic logics from the perspective of technologists

As artificial intelligence (AI) technologies become more ubiquitous for streamlining and optimizing work, they are entering fields representing organizational logics at odds with the efficiency logic of automation. One such field is journalism, an industry defined by a logic enacted through professional norms, practices, and values. This paper examines the experience of technologists developing and employing natural language generation (NLG) in news organizations, looking at how they situate themselves and their technology in relation to newswork. Drawing on institutional logics, a theoretical framework from organizational theory, we show how technologists shape their logic for building these emerging technologies based on a theory of rationalizing news organizations, a frame of optimizing newswork, and a narrative of news organizations misinterpreting the technology. Our interviews reveal technologists mitigating tensions with journalistic logic and newswork by labeling stories generated by their systems as nonjournalistic content, seeing their technology as a solution for improving journalism, enabling newswork to move away from routine tasks. We also find that as technologists interact with news organizations, they assimilate elements from journalistic logic beneficial for benchmarking their technology for more lucrative industries.
Thymoquinone Alterations of the Apoptotic Gene Expressions and Cell Cycle Arrest in Genetically Distinct Triple-Negative Breast Cancer Cells

Breast cancer (BC) is the most common cancer in women worldwide, and it is one of the leading causes of cancer death in women. triple-negative breast Cancer (TNBC), a subtype of BC, is typically associated with the highest pathogenic grade and incidence in premenopausal and young African American (AA) women. Chemotherapy, the most common treatment for TNBC today, can lead to acquired resistance and ineffective treatment. Therefore, novel therapeutic approaches are needed to combat medication resistance and ineffectiveness in TNBC patients. Thymoquinone (TQ) is shown to have a cytotoxic effect on human cancer cells in vitro. However, TQ’s mode of action and precise mechanism in TNBC disease in vitro have not been adequately investigated. Therefore, TQ’s effects on the genetically different MDA-MB-468 and MDA-MB-231 human breast cancer cell lines were assessed. The data obtained show that TQ displayed cytotoxic effects on MDA-MB-468 and MDA-MB-231 cells in a time- and concentration-dependent manner after 24 h, with IC50 values of 25.37 µM and 27.39 µM, respectively. Moreover, MDA-MB-231 and MDA-MB-468 cells in a scratched wound-healing assay displayed poor wound closure, inhibiting invasion and migration via cell cycle blocking after 24 h. TQ arrested the cell cycle phase in MDA-MB-231 and MDA-MB-468 cells. The three cell cycle stages in MDA-MB-468 cells were significantly affected at 15 and 20 µM for G0/G1 and S phases, as well as all TQ concentrations for G2/M phases. In MDA-MB-468 cells, there was a significant decrease in G0/G1 phases with a substantial increase in the S phase and G2/M phases. In contrast, MDA-MB-231 showed a significant effect only during the two cell cycle stages (S and G2/M), at concentrations of 15 and 20 µM for S phases and all TQ values for G2/M phases. The TQ effect on the apoptotic gene profiles indicated that TQ upregulated 15 apoptotic genes in MDA-MB-231 TNBC cells, including caspases, GADD45A, TP53, DFFA, DIABLO, BNIP3, TRAF2/3, and TNFRSF10A. In MDA-MB-468 cells, 16 apoptotic genes were upregulated, including TNFRSF10A, TNF, TNFRSF11B, FADD TNFRSF10B, CASP2, and TRAF2, all of which are important for the apoptotic pathway andsuppress the expression of one anti-apoptotic gene, BIRC5, in MDA-MB-231 cells. Compared to MDA-MB-231 cells, elevated levels of TNF and their receptor proteins may contribute to their increased sensitivity to TQ-induced apoptosis. It was concluded from this study that TQ targets the MDA-MB-231 and MDA-MB-468 cells differently. Additionally, due to the aggressive nature of TNBC and the lack of specific therapies in chemoresistant TNBC, our findings related to the identified apoptotic gene profile may point to TQ as a potential agent for TNBC therapy.
Mathematical surge modeling based on the pressure oscillations in the stable operation range of the compressor

Prevention of surge phenomenon is a very active field of research in last decades. The Greitzer model is the most widely applied mathematical model describing the surge phenomenon. Two parameters that characterize the given compressing system: the Helmholtz oscillator frequency and the so-called B parameter have to be given as the input to Greitzer model. Although those parameters are easy to determine for simplified compressor models, they are extremely hard to predict in case of real industrial compressors. Moreover, in most cases it is impossible to analyse compressor unstable work, which makes this prediction even more speculative. Therefore the method that determines the parameters basing on the compressor stable operation is indispensable. In paper the regularly perturbed Greitzer model based method of predicting the behaviour of a compressor in the unstable operation basing on signals from its stable operation is proposed and discussed.
Exercise with blood flow restriction improves muscle strength and mass while preserving the vascular and microvascular function and structure of older adults.

BACKGROUND Changes in muscle mass, strength, vascular function, oxidative stress, and inflammatory biomarkers were compared in older adults after resistance training (RT) performed with low-intensity without blood flow restriction (RT-CON); low-intensity with BFR (RT-BFR); and high-intensity without BFR (RT-HI). METHODS Thirty-two untrained individuals (72±7 y) performed a 12-week RT after being randomized into three groups: RT-CON -30% of 1 repetition maximum (RM); RT-BFR -30% of 1RM and mild BFR (50% of arterial occlusion pressure); RT-HI -70% of 1 RM. RESULTS Improvements in handgrip strength were similar in RT-BFR (17%) and RT-HI (16%) vs. RT-CON (-0.1% ), but increases in muscle mass (6% vs. 2% and -1%) and IGF-1 (2% vs. -0.1% and -1.5%) were greater (p < 0.05) in RT-BFR vs. RT-HI and RT-CON. Changes in vascular function, morphology, inflammation, and oxidative stress were similar between groups, except for time to reach maximum red blood cell velocity which showed a greater reduction (p < 0.05) in RT-BFR (-55%) vs. RT-HI (-11%) and RT-CON (-4% ). CONCLUSION RT with low intensity and mild BFR improved muscle strength and mass in older individuals while preserving vascular function. This modality should be considered an adjuvant strategy to improve muscle function in older individuals with poor tolerance to high loads.
Circulating Virus–Host Chimera DNAs in the Clinical Monitoring of Virus-Related Cancers

Simple Summary Cell-free tumor DNA (ctDNA), the DNA released into circulation from tumors, is a promising tumor marker with versatile applications. The associations of the amount, somatic mutation frequency, and epigenetic modifications of ctDNA with the tumor burden, tumor behavior, and prognosis have been widely investigated in different types of tumors. However, there are still some challenging issues to be resolved before ctDNA can complement or even replace current serum tumor markers. We propose employing exogenous viral DNA integration that produces unique virus–host chimera DNA (vh-DNA) at junction sites. Cell-free vh-DNA may become a new biomarker because it overcomes background interference detection problems, takes advantage of virus tropism to localize the tumor, and acts as a universal marker for monitoring clonal expansion or tumor loads in tumors related to oncogenic viruses. Abstract The idea of using tumor-specific cell-free DNA (ctDNA) as a tumor biomarker has been widely tested and validated in various types of human cancers and different clinical settings. ctDNA can reflect the presence or size of tumors in a real-time manner and can enable longitudinal monitoring with minimal invasiveness, allowing it to be applied in treatment response assessment and recurrence monitoring for cancer therapies. However, tumor detection by ctDNA remains a great challenge due to the difficulty in enriching ctDNA from a large amount of homologous non-tumor cell-free DNA (cfDNA). Only ctDNA with nonhuman sequences (or rearrangements) can be selected from the background of cfDNA from nontumor DNAs. This is possible for several virus-related cancers, such as hepatitis B virus (HBV)-related HCC or human papillomavirus (HPV)-related cervical or head and neck cancers, which frequently harbor randomly integrated viral DNA. The junction fragments of the integrations, namely virus–host chimera DNA (vh-DNA), can represent the signatures of individual tumors and are released into the blood. Such ctDNA can be enriched by capture with virus-specific probes and therefore exploited as a circulating biomarker to track virus-related cancers in clinical settings. Here, we review virus integrations in virus-related cancers to evaluate the feasibility of vh-DNA as a cell-free tumor marker and update studies on the development of detection and applications. vh-DNA may be a solution to the development of specific markers to manage virus-related cancers in the future.
Keeping Excitation–Inhibition Ratio in Balance

Unrelated genetic mutations can lead to convergent manifestations of neurological disorders with similar behavioral phenotypes. Experimental data frequently show a lack of dramatic changes in neuroanatomy, indicating that the key cause of symptoms might arise from impairment in the communication between neurons. A transient imbalance between excitatory (glutamatergic) and inhibitory (GABAergic) synaptic transmission (the E/I balance) during early development is generally considered to underlie the development of several neurological disorders in adults. However, the E/I ratio is a multidimensional variable. Synaptic contacts are highly dynamic and the actual strength of synaptic projections is determined from the balance between synaptogenesis and synaptic elimination. During development, relatively slow postsynaptic receptors are replaced by fast ones that allow for fast stimulus-locked excitation/inhibition. Using the binomial model of synaptic transmission allows for the reassessing of experimental data from different mouse models, showing that a transient E/I shift is frequently counterbalanced by additional pre- and/or postsynaptic changes. Such changes—for instance, the slowing down of postsynaptic currents by means of immature postsynaptic receptors—stabilize the average synaptic strength, but impair the timing of information flow. Compensatory processes and/or astrocytic signaling may represent possible targets for medical treatments of different disorders directed to rescue the proper information processing.
Symbiotic organisms search algorithm for automatic generation control of interconnected power systems including wind farms

Automatic generation control (AGC) plays an important role in power systems, where it maintains the system frequency and tie-line power flow at their desired values. This study presents a novel symbiotic organisms search (SOS) algorithm in order to optimally design the proportional–integral–derivative (PID) controllers in the AGC of interconnected multiple-area power systems including wind farms uncertainty and system non-linearity. The PID controllers’ parameters define the design variables of the optimisation problem. The SOS algorithm is applied to different objective functions such as integral square error and integral absolute of error. The efficacy of the proposed controller is compared with other competing evolutionary algorithms-based proportional–integral or PID controller. The system performance is evaluated under different operating conditions such as different loading, variation of system parameters, and an addition of wind energy uncertainty. For obtaining realistic responses, real wind speed data that extracted from Zafarana location in Egypt is used in this study. The validity of the proposed controller is extensively confirmed using the simulation results. With the SOS-based PID controllers, the dynamic responses for the AGC of interconnected power systems, including wind farms uncertainty can be further enhanced.
Status quo of genetic improvement in local goats: a review

Abstract This review aims to summarize and synthesize the fragmented information available on the genetic improvement of local goats (criollo, indigenous, native) on the American and other continents, where populations with these goats have an important role in food security and the economy of rural communities, as well as in conservation of biodiversity and productivity improvement. Topics such as the current state of goat production globally, conservation programs, resistance to parasites and diseases, use of phenotypical characteristics and genomic information, and molecular markers for genetic improvement are addressed. The main challenges, opportunities, and limitations described in recent literature concerning local goats in the immediate future are discussed.
The origin of unwanted editing byproducts in gene editing

The rapid development of CRISPR-Cas genome editing tools has greatly changed the way to conduct research and holds tremendous promise for clinical applications. During genome editing, CRISPR-Cas enzymes induce DNA breaks at the target sites and subsequently the DNA repair pathways are recruited to generate diverse editing outcomes. Besides off-target cleavage, unwanted editing outcomes including chromosomal structural variations and exogenous DNA integrations have recently raised concerns for clinical safety. To eliminate these unwanted editing byproducts, we need to explore the underlying mechanisms for the formation of diverse editing outcomes from the perspective of DNA repair. Here, we describe the involved DNA repair pathways in sealing Cas enzyme-induced DNA double-stranded breaks and discuss the origins and effects of unwanted editing byproducts on genome stability. Furthermore, we propose the potential risk of inhibiting DNA repair pathways to enhance gene editing. The recent combined studies of DNA repair and CRISPR-Cas editing provide a framework for further optimizing genome editing to enhance editing safety.
Power Quality Improvement Using Hybrid Passive Filter Configuration for Wind Energy Systems

Wind energy conversion systems (WECS) which consist of wind turbines with permanent magnet synchronous generator (PMSG) and full-power converters have become widespread in the field of renewable power systems. Generally, conventional diode bridge rectifiers have used to obtain a constant DC bus voltage from output of PMSG based wind generator. In recent years, together advanced power electronics technology, Pulse Width Modulation (PWM) rectifiers have used in WECS. PWM rectifiers are used in many applications thanks to their characteristics such as high power factor and low harmonic distortion. In general, L, LC and LCL-type filter configurations are used in these rectifiers. These filter configurations are not exactly compensate current and voltage harmonics. This study proposes a hybrid passive filter configuration for PWM rectifiers instead of existing filters. The performance of hybrid passive filter was tested via MATLAB/Simulink environment under various operational conditions and was compared with LCL filter structure. In addition, neuro-fuzzy controller (NFC) was preferred to increase the performance of PWM rectifier in DC bus voltage control against disturbances because of its robust and nonlinear structure. The study demonstrates that the hybrid passive filter configuration proposed in this study successfully compensates current and voltage harmonics, and improves total harmonic distortion and true power factor.
A Single Injection of NTG-101 Reduces the Expression of Pain-Related Neurotrophins in a Canine Model of Degenerative Disc Disease

Background: Tissue sources of pain emanating from degenerative discs remains incompletely understood. Canine intervertebral discs (IVDs) were needle puncture injured, 4-weeks later injected with either phosphate-buffered saline (PBS) or NTG-101, harvested after an additional fourteen weeks and then histologically evaluated for the expression of NGFr, BDNF, TrkB and CALCRL proteins. Quantification was performed using the HALO automated cell-counting scoring platform. Immunohistochemical analysis was also performed on human IVD tissue samples obtained from spinal surgery. Immunohistochemical analysis and quantification of neurotrophins and neuropeptides was performed using an in vivo canine model of degenerative disc disease and human degenerative disc tissue sections. Discs injected with NTG-101 showed significantly lower levels of Nerve Growth Factor receptor (NGFr/TrkA, p = 0.0001), BDNF (p = 0.009), TrkB (p = 0.002) and CALCRL (p = 0.008) relative to PBS injections. Human IVD tissue obtained from spinal surgery due to painful DDD show robust expression of NGFr, BDNF, TrkB and CALCRL proteins. A single intradiscal injection of NTG-101 significantly inhibits the expression of NGFr, BDNF, TrkB and CALCRL proteins in degenerative canine IVDs. These results strongly suggest that NTG-101 inhibits the development of neurotrophins that are strongly associated with painful degenerative disc disease and may have profound effects upon the management of patients living with discogenic pain.
Experimental Study and Modeling of the Effect of ESDD/NSDD on AC Flashover of SiR Outdoor Insulators

Pollution flashover occurs when soluble and nonsoluble materials cover the surface of an insulator, and this may ultimately cause a reduction in its performance. In this paper, the common type of sodium chloride (NaCl) was used as a soluble pollutant (ESDD) and kaolin as a nonsoluble pollutant (NSDD). Samples of silicone rubber (SiR) insulators were selected for this study and fabricated at the Advanced High Voltage Engineering Research Centre (AHIVEC) at Cardiff University. The samples were preconditioned and polluted according to standard specifications. Additionally, the AC voltage ramp technique was used to achieve flashover (FOV) voltage with different pollution levels. The aim of this work was to investigate the effect of nonsoluble materials on flashover characteristics to understand their interaction with dry-band arcs by using FOV electrical equations and experimental data. The test results show that the FOV voltage of the silicone rubber insulator substantially decreased with the increase in both ESDD and NSDD values. It was also identified from these results that the dry-band arcs were considerably influenced by both ESDD and NSDD levels. This impact can be quantified by determining the variation of discharge parameters (N, n). Based on the FOV equations and experimental data, a mathematical model was suggested, taking into account the effect of both ESDD and NSDD.
Stability of Cantilever Fixed Dental Prostheses on Zirconia Implants

Background: The objective was to determine the optimal connector size and position within zirconia disks for implant-supported cantilever fixed dental prostheses (ICFDP). Methods: Two-unit ICFDPs (n = 60) were designed for the premolar region with connector sizes of either 9 or 12 mm2 and positioned in the enamel or dentin layer of two different types of zirconia disks. The restorations were milled and cemented onto zirconia implants. After simulated chewing for 1.2 Mio cycles, the fracture load was measured and fractures were analyzed. Results: No fractures of ICFDPs or along the implants were detected after simulated aging. The mean fracture load values were significantly higher for a connector size of 9 mm2 (951 N) compared with 12 mm2 (638 N). For the zirconia material with a higher biaxial flexural strength, the fracture load values were increased from 751 to 838 N, but more implant fractures occurred. The position within the zirconia disk did not influence the fracture load. Conclusions: A connector size of 9 mm2 and a zirconia material with a lower strength should be considered when designing ICFDPS on zirconia implants to reduce the risk of fractures along the intraosseous implant portion.
Automatic licence plate detection using adaptive neuro fuzzy inference system and wavelet packets

Abstract This paper presents an automatic licence plate detection (ALPD) system to improve the road safety and to monitor the vehicle movement on the streets. The system comprises a surveillance camera mounted at possible speeding points or at illegal parking zones which captures images and processes them to identify the errant vehicle owners for initiating appropriate legal action. The proposed scheme is cost-efficient and substantially reduces the manpower required to monitor the streets. ALPD uses a combination of K-Means Clustering and adaptive neuro-fuzzy inference system (ANFIS) to detect the Licence Plate from a given image. Wavelet Packet analysis and ANFIS are used to identify the alphanumeric characters. The scheme was tested on a sample of 52 test images pertaining to different configurations of the licence plate in terms of its location or font and using diverse colours of the vehicles, and was determined to have an accuracy of 98.3% and an average computational time of 900 ms. The algorithm was found to be robust, time efficient and has high recognition rate compared to many other schemes currently in practice. The use of Wavelet Packet analysis also makes the proposed scheme immune to variations pertaining to the font of the characters used for the licence plates.
An Ancient Wisdom on Exercise and Health Promotion

Tai chi chuan (TCC) is a Chinese conditioning exercise and is well known for its slow and graceful movements. Recent investigations have found that TCC is beneficial to cardiorespiratory function, strength, balance, flexibility, microcirculation and psychological profile. The long-term practice of TCC can attenuate the age decline in physical function, and consequently it is a suitable exercise for the middle-aged and elderly individuals. TCC can be prescribed as an alternative exercise programme for selected patients with cardiovascular, orthopaedic, or neurological diseases, and can reduce the risk of falls in elderly individuals. The exercise intensity of TCC depends on training style, posture and duration. Participants can choose to perform a complete set of TCC or selected movements according to their needs. In conclusion, TCC has potential benefits in health promotion, and is appropriate for implementation in the community.