Miracle-dz/UniFAR-FTUs huggingface dataset:
A Review of Pseudomonas aeruginosa Metallophores: Pyoverdine, Pyochelin and Pseudopaline

Simple Summary The human pathogen Pseudomonas aeruginosa (P. aeruginosa) causes several infections, both acute and chronic, mainly in hosts with compromised immunity and in patients suffering from cystic fibrosis. The pathogenesis of this bacterium is caused by several factors. Metallophores, which are molecules for sequestering metal ions, are among these factors. P. aeruginosa secretes three types of metallophores, two for iron chelation (siderophores) named pyoverdine and pyochelin and the third one (pseudopaline) which can chelate zinc, nickel and cobalt. This review sums up in one paper all the important characteristics of these three metallophores, including their biosynthesis process, secretion, uptake after metal chelating and genetic regulation. Abstract P. aeruginosa is a common Gram-negative bacterium found in nature that causes severe infections in humans. As a result of its natural resistance to antibiotics and the ability of biofilm formation, the infection with this pathogen can be therapeutic challenging. During infection, P. aeruginosa produces secondary metabolites such as metallophores that play an important role in their virulence. Metallophores are metal ions chelating molecules secreted by bacteria, thus allowing them to survive in the host under metal scarce conditions. Pyoverdine, pyochelin and pseudopaline are the three metallophores secreted by P. aeruginosa. Pyoverdines are the primary siderophores that acquire iron from the surrounding medium. These molecules scavenge and transport iron to the bacterium intracellular compartment. Pyochelin is another siderophore produced by this bacterium, but in lower quantities and its affinity for iron is less than that of pyoverdine. The third metallophore, pseudopaline, is an opine narrow spectrum ion chelator that enables P. aeruginosa to uptake zinc in particular but can transport nickel and cobalt as well. This review describes all the aspects related to these three metallophore, including their main features, biosynthesis process, secretion and uptake when loaded by metals, in addition to the genetic regulation responsible for their synthesis and secretion.
Telesonar: Robocall Alarm System by Detecting Echo Channel and Breath Timing

Massive fraudulent and phishing robocalls present threats to societies. The integration of artificial intelligence technologies, including dialogue and voice generation systems, renders the robocalls more deceptive. Existing countermeasures such as caller ID, call provenance, voiceprint, and fake voice detection have respective limitations and are heavyweight for end users' smartphones. This paper studies detecting the acoustic echo channel on the remote end of a call based on the received voice. The positive detection result evidencing the physical setup of an audio system is indicative of a human caller. However, the acoustic echo cancellation mechanisms of most audio systems and the use of earphone/headset diminish echoes significantly. To address these issues, the proposed Telesonar transmits short chirps during the vulnerable time of echo cancellation, detects the tiny echo remnants from the received voice, and passively analyzes the timing of caller's breath sounds to confirm a human caller. Extensive real experiments under a wide range of settings show that Telesonar correctly recognizes human callers with a rate of over 95%, while wrongly recognizing voice robots as human with a rate of 3.8%.
CaMKIIα as a Promising Drug Target for Ischemic Grey Matter

Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a major mediator of Ca2+-dependent signaling pathways in various cell types throughout the body. Its neuronal isoform CaMKIIα (alpha) centrally integrates physiological but also pathological glutamate signals directly downstream of glutamate receptors and has thus emerged as a target for ischemic stroke. Previous studies provided evidence for the involvement of CaMKII activity in ischemic cell death by showing that CaMKII inhibition affords substantial neuroprotection. However, broad inhibition of this central kinase is challenging because various essential physiological processes like synaptic plasticity rely on intact CaMKII regulation. Thus, specific strategies for targeting CaMKII after ischemia are warranted which would ideally only interfere with pathological activity of CaMKII. This review highlights recent advances in the understanding of how ischemia affects CaMKII and how pathospecific pharmacological targeting of CaMKII signaling could be achieved. Specifically, we discuss direct targeting of CaMKII kinase activity with peptide inhibitors versus indirect targeting of the association (hub) domain of CaMKIIα with analogues of γ-hydroxybutyrate (GHB) as a potential way to achieve more specific pharmacological modulation of CaMKII activity after ischemia.
Book Discusson Bending and Stretching the De ﬁ nition of Lying

One of the recent trends in dealing with the concept of lying has been to argue that the idea that one needs to deceive someone in order to lie has been accepted too hastily. In Lying and Insincerity Stokke shares this opinion and proposes a de ﬁ nition of lying based on the notion of common ground that includes bald-faced lies. Additionally, he rejects the idea that lying can be accomplished with pragmatic means such as conversational implicatures and proposes a formal distinction between lying and misleading. In this review, I present the content of Stokke’s book and critically discuss the two points mentioned above.
Lack of Detection of Toxoplasma gondii in Pipistrellus spp. Bats from Densely Cat-Populated Areas of NE Spain

Toxoplasma gondii infection in healthy animals is often asymptomatic. However, some species with little history of contact with the parasite, such as marsupials and New World primates, present high mortality rates after infection. Despite its potential conservation concern, T. gondii infection in insectivorous bats has received little attention, and its impact on bat populations’ health is unknown. To assess the putative role of insectivorous bats in the cycle of T. gondii, samples of three species of bats (Pipistrellus pipistrellus, P. pygmaeus and P. kuhlii) collected between 2019 and 2021 in NE Spain were tested for the presence of the parasite using a qPCR. All tissues resulted negative (0.0% prevalence with 95% CI: [0.0–2.6]) for the presence of T. gondii. Unlike previous studies on insectivorous bats from Europe, Asia and America, the present study suggests that Pipistrellus spp. bats do not play a significant role in the epidemiology of T. gondii in NE Spain. Further studies are encouraged to elucidate both the epidemiology of T. gondii and its potential impact on the health of microchiropteran species in Europe.
Energy spectrum of α-particles escaping from a plasma as a result of turbulent diffusion

On the assumption that the main reason for the escape of α-particles from plasma is turbulent diffusion, the authors find the fraction of thermonuclear reaction energy transmitted to the plasma, the flux of α-particles escaping from the plasma and the energy distribution of the particles. The energy distribution depends to a great extent on whether quasi-linear relaxation of the α-particle distribution function is appreciable or not. The case of negligibly small quasi-linear distortion of the α-particle distribution is examined, as well as the case where quasi-linear effects are dominant. It is shown that the energy spectrum of the α-particles leaving the plasma as a result of turbulent diffusion contains both slowed-down and accelerated (ϵ > 3.5 MeV) particles.
LARGE-SCALE MAGNETIC HELICITY FLUXES ESTIMATED FROM MDI MAGNETIC SYNOPTIC CHARTS OVER THE SOLAR CYCLE 23

To investigate the characteristics of large-scale and long-term evolution of magnetic helicity with solar cycles, we use the method of Local Correlation Tracking to estimate the magnetic helicity evolution over solar cycle 23 from 1996 to 2009 using 795 MDI magnetic synoptic charts. The main results are as follows: the hemispheric helicity rule still holds in general, i.e., the large-scale negative (positive) magnetic helicity dominates the northern (southern) hemisphere. However, the large-scale magnetic helicity fluxes show the same sign in both hemispheres around 2001 and 2005. The global, large-scale magnetic helicity flux over the solar disk changes from a negative value at the beginning of solar cycle 23 to a positive value at the end of the cycle, while the net accumulated magnetic helicity is negative in the period between 1996 and 2009.
Structure and stability of sputter deposited beta‐tungsten thin films

The structure and stability of thin tungsten films prepared by radio frequency magnetron sputter deposition have been studied by x‐ray diffraction and x‐ray photoelectron spectroscopy. The structure of these films has been found to systematically evolve from the metastable A15 β‐W phase to the equilibrium A2 α‐W phase with decreasing oxygen impurity concentration. Within the β‐W phase a decrease in the concentration of incorporated oxygen results in a monotonic decrease in the lattice parameter of the unit cell until the β‐W phase eventually becomes unstable, and the α‐W phase is formed.
Magnetochromatics of the magnetic fluid film under a dynamic magnetic field

The structure and the corresponding magnetochromatics of homogeneous magnetic fluid films under dynamic magnetic fields perpendicular to the film surfaces are investigated in this letter. During the application of a magnetic field from 0 up to 200 Oe, the structure in the magnetic fluid film evolves from a monodispersed state to a disordered-column state, and then to an ordered hexagonal structure. The column spacing for the instant hexagonal structure during the dynamic process was measured and found to vary from 2.41 to 1.83 μm when the field strength was raised from 60 to 200 Oe. Within this range, the hexagonal structure diffracts the visible light like an optical grating. Due to the dynamic variation of the column spacing with the increasing field strength, the color of the diffracted light changed unceasingly from red to blue when observed from a fixed point above the film. The results strongly suggest the possibility that optical devices may be developed by utilizing the magnetochromatics of magnet.
Amorphous In–Ga–Zn–O coplanar homojunction thin-film transistor

A fabrication process of coplanar homojunction thin-film transistors (TFTs) is proposed for amorphous In–Ga–Zn–O (a-IGZO), which employs highly doped contact regions naturally formed by deposition of upper protection layers made of hydrogenated silicon nitride (SiNX:H). The direct deposition of SiNX:H reduced the resistivity of the semiconductive a-IGZO layer down to 6.2×10−3 Ω cm and formed a nearly ideal Ohmic contact with a low parasitic source-to-drain resistance of 34 Ω cm. Simple evaluation of field-effect mobilities (μsat) overestimated their values especially for short-channel TFTs, while the channel resistance method proved that μsat was almost constant at 9.5 cm2 V−1 s−1.
AN ALTERNATIVE MODEL FOR 29 UW CANIS MAJORIS

a) Ha displays an approximately stationary broad emission. b) The emission of Hen A, 4686 changes in profile throughout the cycle, becoming diffuse or double at about secondary minimum (when the Of component is in front) and definitely double before primary minimum (the doubling was observed on plates taken at phases near 0? 8). In the latter case, the extra component is weak and appears to the violet of the "regular" emission. c) The radial velocities from the emission lines of He n and N in suggest a velocity curve similar to that from the absorption lines but systematically shifted to more positive values, except near quadrature after primary minimum, when the velocities are more negative than those from the absorption lines. d) The velocities from the absorption core of Ha are, in the first half and the last quarter of the cycle, systematically more negative than those from the absorption lines ; in the rest of the cycle, the velocities are practically coincident with the y-velocity.
HIGEA: An Intelligent Conversational Agent to Detect Caregiver Burden

Mental health disorders increasingly affect people worldwide. As a consequence, more families and relatives find themselves acting as caregivers. Most often, these are untrained people who experience loneliness, abandonment, and often develop signs of depression (i.e., caregiver burden syndrome). In this work, we present HIGEA, a digital system based on a conversational agent to help to detect caregiver burden. The conversational agent naturally embeds psychological test questions into informal conversations, which aim at increasing the adherence of use and avoiding user bias. A proof-of-concept is developed based on the popular Zarit Test, which is widely used to assess caregiver burden. Preliminary results show the system is useful and effective.
Token Economy as the Intervention of Self-Injurious Behavior in Students with Mental Retardation

Self-injury in children with mental retardation is caused by their inability to express their feelings and emotions. This study aimed to describe self-injury experienced by students with mental retardation and examine the influence of the token economy on the self-injury of students with mental retardation at the special school (SLB) Bhakti Pemuda, Tamanan, Kediri. The study used a quantitative approach with experimental methods based on the pre-experimental design with the one-group pretest posttest design. Based on the exclusion criteria, there were five children experienced mental retardation, and they were selected using the purposive sampling technique. The researchers conducted a pre-test, treatment, and post-test. The data was analyzed using the IBM SPSS 20 program. The results showed that the self-injury in students with mental retardation at SLB Bhakti Pemuda, Tamanan, Kediri included hitting themselves, hitting tables and chairs, running, pulling their hair, hurting themselves using pencils, experiencing anxiety continuously, and being unable to control emotions.
A study of staff nurses' perceptions of nursing leadership styles and work engagement levels in Saudi general hospitals

Leadership styles are meaningful in facing obstacles in healthcare, such as improving quality of care and performance of safety, minimizing expense, and keeping high-performing nursing staff; as a result, they can positively or negatively affect nursing work engagement, which has an impact on employee satisfaction, patient satisfaction, and organizational productivity. Thus the objective of this study is to determine the perception of the relationship between nurse managers' leadership styles and the levels of work engagement of the staff nurses in the Kingdom of Saudi Arabia. This study used a quantitative, descriptive, cross-sectional, and correlational design. A convenience sampling technique was used to select 383 staff nurses working in governmental hospitals in Saudi Arabia. The Utrecht Work Engagement Scale and the Multifactorial Leadership Questionnaire 5X short form were used to collect data. The study found that transformational leadership style (M±SD: 2.34±.946) and transactional leadership style (M±SD: 2.03±.686) had the highest mean scores from staff nurses' perceptions, while laissez-faire leadership style (M±SD: 1.4±.991) had the lowest mean score. Moreover, the highest mean score of staff nurses’ work engagement was dedication (M±SD: 4.80±1.380), and the lowest mean score for vigor (M±SD: 4.02±1.424). There was a strong statistically significant positive relationship between transformational and transactional leadership styles and staff nurses' levels of work engagement (r=0.591, r=0.517, P=0.000), respectively, while there was a negative but not statistically significant relationship between laissez-faire leadership style and staff nurses' levels of work engagement (r=-0.023 and p=0.64). Nurse managers who utilize transformational and transactional leadership approaches to empower and collaborate with staff nurses can improve organizational performance.
Big Data and Infectious Disease Epidemiology: Bibliometric Analysis and Research Agenda

Background Infectious diseases represent a major challenge for health systems worldwide. With the recent global pandemic of COVID-19, the need to research strategies to treat these health problems has become even more pressing. Although the literature on big data and data science in health has grown rapidly, few studies have synthesized these individual studies, and none has identified the utility of big data in infectious disease surveillance and modeling. Objective The aim of this study was to synthesize research and identify hotspots of big data in infectious disease epidemiology. Methods Bibliometric data from 3054 documents that satisfied the inclusion criteria retrieved from the Web of Science database over 22 years (2000-2022) were analyzed and reviewed. The search retrieval occurred on October 17, 2022. Bibliometric analysis was performed to illustrate the relationships between research constituents, topics, and key terms in the retrieved documents. Results The bibliometric analysis revealed internet searches and social media as the most utilized big data sources for infectious disease surveillance or modeling. The analysis also placed US and Chinese institutions as leaders in this research area. Disease monitoring and surveillance, utility of electronic health (or medical) records, methodology framework for infodemiology tools, and machine/deep learning were identified as the core research themes. Conclusions Proposals for future studies are made based on these findings. This study will provide health care informatics scholars with a comprehensive understanding of big data research in infectious disease epidemiology.
Comparative Toxicity of Heavy Metals Cd, Pb, and Zn to Three Acrocarpous Moss Species using Chlorophyll Contents

Mosses have often been used for biomonitoring because of their diversity of habitats, structural simplicity, and rapid multiplication rate. This research aimed to study the tolerance of heavy metal in 3 species of terricolous mosses i.e., Barbula consanguinea , Hyophila apiculata , and H. involuta. The gametophores of mosses were immersed at 4 concentrations of each of the heavy metals Cd, Pb, and Zn as well as in controls with no heavy metal. After 10, 20, and 30 days of exposure, mosses were extracted for chlorophyll-a in ethanol. The extracted chlorophyll-a was analyzed by spectrophotometer at 664 nm. The results revealed that the amount of chlorophyll-a in all species decreased with increasing concentrations of Cd, Pb, and Zn. The degree of metal toxicity for all species was Cd > Pb > Zn. By comparing the ratio of extracted chlorophyll-a in heavy metal-treated mosses to chlorophyll-a extracted in control mosses, the tolerance against 3 heavy metals in 3 mosses was H. involuta > B. consanguinea > H. apiculata . Possibly, H. involuta can be used for biomonitoring of heavy metals in contaminated environments in the future.
Interactions between concerns for the environment and other sources of concern in 31 European countries

Understanding how different sources of concern interact in people’s mind is a question that has entertained generations of scholars. The finite-pool-of-worry (FPW) hypothesis states that humans have limited resources to worry, thus when they are worried about one issue they become less worried about other issues. Instead, the affect generalization theory (AGT) posits that an increased level of worry about one threat increases concerns about related threats. To this end, we adopt a Lotka–Volterra model to detect instances of AGT and FPW among worries for the environment, economy, safety, social issues and immigration in 31 European countries between 2012 and 2019 (Eurobarometer data). Consistently with AGT, we find that an increase in the concern for the environment often favors the growth of concerns for the economy. Meanwhile, consistently with FPW, an increase in the concerns for the economy and for other sources of worry, often pushes down concerns for the environment. Building on our results, we hypothesize the existence of a pyramid of worries. At the bottom of the pyramid lie worries like concerns for the economy, which generally predate other worries. Concerns for the environment lie at the very top of the pyramid as they are generally predated by other worries. Last, we find that AGT and FPW can coexist not only over time and across countries, but also as a result of an asymmetric interaction.
Gravitational wave chirp search: no-signal cumulative distribution of the maximum likelihood detection statistic

The cumulative distribution of the supremum of a set (bank) of correlators is investigated in the context of maximum likelihood detection of gravitational wave chirps from coalescing binaries with unknown parameters. Accurate (lower-bound) approximants are introduced based on a suitable generalization of previous results by Mohanty. Asymptotic properties (in the limit where the number of correlators goes to infinity) are highlighted. The validity of numerical simulations made on small-size banks is extended to banks of any size, via a Gaussian correlation inequality.
Large-scale Hi structure of the Circinus galaxy

HI observations with the Australia Telescope Compact Array (ATCA) are used to study the neutral gas distribution and kinematics of the Circinus galaxy. One of the most outstanding features of Circinus is its enormous size (at least 80 arcmin or nearly 100 kpc, assuming a distance of 4 Mpc) revealing a beautiful large-scale spiral pattern. The fit of a tilted-ring model to the velocity field reveals a strong kinematic warp of the outer spiral arms. The inner region (radius 250 arcsec or 5 kpc) contains a highly elongated structure with non-circular motions, suggesting that Circinus is a barred spiral galaxy. At the centre of Circinus there is a 50-arcsec or 1-kpc-radius HI ring or disc rotating with a speed of at least 200 km s-1.
Secure Location Privacy Transmitting Information on Cellular Networks

As smartphones incorporate location data, there is a growing concern about location privacy as smartphone technologies advance. Using a remote server, the mobile applications are able to capture the current location coordinates at any time and store them. The client awards authorization to an outsider. The outsider can gain admittance to area information on the worker by JSON Web Token (JWT). Protection is giving cover to clients, access control, and secure information stockpiling. Encryption guarantees the security of the location area on the remote server using the Rivest Shamir Adleman (RSA) algorithm. This paper introduced two utilizations of cell phones (tokens, and location). The principal application can give area information by means of the geographic position method of these gadgets. Every cell phone can create a token. The token holds secret keys got from versatile fixed identifiers for the most part of the Social Security Number (SSN) for each SIM (Endorser Personality Module) Chronic Number) and IMEI (Global Portable Hardware Character) by RSA calculation. The token is going through the short and informative administration of Short Message Service (SMS) from the client to the outsider. Information is scrambled before being stored on a faraway worker. The actual worker can't comprehend the area’s information. The third-party cannot follow the area if the client utilizes distinctive mystery keys. The client’s data and area information are saved by the various workers. The proposed application offers a mysterious sharing instrument that uses token verification to grant clients access to scrambled area data and provides encryption data in a remote server with an authentication token, achieving mutual authentication on each mobile device and user concealment.