Miracle-dz/UniFAR-FTUs huggingface dataset:
EVA enhances the interfacial strength of EPS concrete: a molecular dynamics study

Abstract Expanded polystyrene (EPS) concrete has high environmental and economic benefits. However, the difference in physical and chemical properties leads to a weak interface between EPS and concrete, which limits the use of EPS concrete. Based on the macro experiment of Ethylene Vinyl Acetate Copolymer (EVA) modified EPS concrete, two molecular dynamics interface models of EPS/C-S-H and EPS/EVA/C-S-H were constructed by molecular dynamics simulation, and their interface strengthening mechanism was discussed. The results of interfacial interaction analysis show that EVA increases the interfacial interaction energy and binding energy between EPS and C-S-H, and improves the adhesion between EPS and cement base. The results of radial distribution function analysis show that in the model with the modifier, there are not only Van der Waals forces and hydrogen bonds in the model without the modifier, but also strong interactions such as Ca - = O and OT - = O. The results of mechanical property analysis show that the elastic modulus of EPS concrete interface model after adding modifier is improved, and its interface properties are improved. The molecular dynamics simulation carried out in this paper shows that EVA acts as a bridge between EPS and C-S-H and enhances its interfacial properties. This study can provide basic theoretical support for the application of EPS concrete and reference for the development of high-performance composite cement-based materials. Graphical Abstract
Myths About Linear and Monotonic Associations: Pearson’s r, Spearman’s ρ, and Kendall’s τ

Abstract Pearson’s correlation coefficient is considered a measure of linear association between bivariate random variables X and Y. It is recommended not to use it for other forms of associations. Indeed, for nonlinear monotonic associations alternative measures like Spearman’s rank and Kendall’s tau correlation coefficients are considered more appropriate. These views or opinions on the estimation of association are strongly rooted in the statistical and other empirical sciences. After defining linear and monotonic associations, we will demonstrate that these opinions are incorrect. Pearson’s correlation coefficient should not be ruled out a priori for measuring nonlinear monotonic associations. We will provide examples of practically relevant families of bivariate distribution functions with nonlinear monotonic associations for which Pearson’s correlation is preferred over Spearman’s rank and Kendall’s tau correlation in testing the dependency between X and Y. Alternatively, we will provide a family of bivariate distributions with a linear association between X and Y for which Spearman’s rank and Kendall’s tau are preferred over Pearson’s correlation. Our examples show that existing views on linear and monotonic associations are myths.
Bumper contact sensor for pedestrian collisions based on analysis of pedestrian kinematic behaviour

An active bonnet and pedestrian airbag are effective in providing a high level of pedestrian head protection. For triggering the activation of these systems, a reliable sensor that distinguishes a pedestrian collision from collisions against other colliding objects is necessary. In this research, a pedestrian contact sensor based on the pressure of a deformable chamber was investigated from finite-element (FE) analysis. In a simulation of a component test of a chamber impact, the internal pressure of the chamber increased with the volume deformation of the chamber according to Boyle's law. The chamber was installed above the top plane of the bumper energy absorber of a simple car model, and FE simulations of a car–pedestrian collision were conducted. The chamber deformed and its internal pressure increased as the bumper energy absorber deformed during contact with the pedestrian leg. It was shown that the pressure response of the chamber could be detected, irrespective of vehicle shape and structure. This particular pressure response in pedestrian collisions was different from that in collisions into other objects such as a road pole. The contact force of the bumper energy absorber tends to be linear with the pressure change of the chamber. It was shown that a pedestrian collision can be distinguished with high reliability from other colliding objects using the chamber pressure based on the colliding characteristics depending on each colliding object.
Research Advances on the Interactions between Rabies Virus Structural Proteins and Host Target Cells: Accrued Knowledge from the Application of Reverse Genetics Systems

Rabies is a lethal zoonotic disease caused by lyssaviruses, such as rabies virus (RABV), that results in nearly 100% mortality once clinical symptoms appear. There are no curable drugs available yet. RABV contains five structural proteins that play an important role in viral replication, transcription, infection, and immune escape mechanisms. In the past decade, progress has been made in research on the pathogenicity of RABV, which plays an important role in the creation of new recombinant RABV vaccines by reverse genetic manipulation. Here, we review the latest advances on the interaction between RABV proteins in the infected host and the applied development of rabies vaccines by using a fully operational RABV reverse genetics system. This article provides a background for more in-depth research on the pathogenic mechanism of RABV and the development of therapeutic drugs and new biologics.
Comparing Public Responses to Emerging And Nuclear Waste Disp osal Technologies: A Case Study- 11380

Scientists who work in emerging technologies focus on the advantages and are surprised by the sometimes negative responses from citizens who question the use of such technologies. Social scientists have explored the sources of this sometimes contentious debate in emerging technologies such as biotechnology and nanotechnology [1]. While radioactive waste disposal does not qualify as an em erging technology per se, response to Yucca Mountain as a proposed disposal site shows that tensions remain [2,3,4]. This paper identifies theories and empirical results from multiple literatures to explore and compare public responses to nanotechnology, biotechnology, and nuclear technologies. Several issues arise while exploring what is known about public response to each technology. Given the importance of nuclear waste management and disposal [5] for present and future generations, research fro m the social sciences may offer a more constructive approach to the substantive problems that may arise for the general public when considering emerging or mature technologies.
Low phase noise LC VCO with reduced drain current duty cycle

A novel LC VCO topology with switched current source is presented. Theoretical analysis is given to show the reduction of cross-paired transistors' drain current duty cycle with the implementation of current source switching, which reduces the upconversion of 1/f noise and also provides noise shaping by directly reducing 1/f noise. A 5.25'5.5 GHz LC VCO has been fabricated and measured for the proposed topology, achieving a FOM of '191 dBc/Hz, which is among the best published FOM results for 5'6 GHz VCOs in standard CMOS process.
Design Simulation and Fabrication of Stepped Impedance Microstripline Low Pass Filter for S-band Application using IE3D and MATLAB

Most communication system contain an RF front end which performs signal processing with RF filters. Micro strip filters are a low cost means of doing this. Filters play an important role in microwave applications. Micro strip filters play various roles in wireless or mobile communication systems. There is an increasing demand for newer microwave and millimeter-wave systems to meet the emerging telecommunication challenges with respect to size, performance and cost. This paper describes the design of low cost and low insertion loss S-band Low Pass Filter (LPF) by using micro strip layout which works at 2.5 GHz for permittivity 4.4 value with a substrate thickness 1.6mm for order n=6.Microstrip technology is used for simplicity and ease of fabrication. The design and simulation are performed using 3D full wave electromagnetic simulator IE3D. We have also develop program code in MATLAB to plot the insertion loss (S21 parameter) of the Low pass filter.
Evaluation of Efficacy and Determining Various Factors Associated with the Effective Use of Vitamin-K Antagonist Therapy in the Indian Population

Aim: To assess the efficacy of Vitamin K antagonist to maintain stable INR in a tertiary care hospital. Methodology: All the patients who are on Vitamin K antagonists therapy for more than 6 months before the initiation of the study were included. Data, which include demographics, Personal history, medical history, medication history, Dietary habits, laboratory data (INR), and other relevant data, are collected. The laboratory results are further evaluated using the Rosendaal method and Time in Therapeutic Range, which was obtained which is evaluated, for assessing the use of medication, and other correlations were further made. Results and Discussion: The study showed a mean TTR of 25.638%, the mean TTR above and below the therapeutic range is 19.23% (±17.14), 55.11% (±29.64) respectively, this represents that the patients in the sample population are at higher risk of developing a new clot during the therapy with VKA, various chronic conditions such as Diabetes mellitus, the use of NSAIDs, PPI also showed a statistically significant difference on the patients TTR. Conclusion: Despite patients being therapeutically anticoagulated, based on the available data, many patients in the study population are at high risk of developing complications of anticoagulants and also the development of new clots even during the treatment, there are not many reports of TTR measurement in INDIAN population, The use of Vitamin K Antagonist comes with many limitations, many Newer Oral Anticoagulants (NOAC) can be used in patients as they are proven to be providing better control of TTR.
EPID-26. ALIGNING THE CBTRUS HISTOLOGY GROUPS WITH 2016 WHO CLASSIFICATION OF TUMORS OF THE CENTRAL NERVOUS SYSTEM

The Central Brain Tumor Registry of the United States (CBTRUS) uses a histology grouping scheme modeled after the World Health Organization (WHO) Classification of Tumours of the Central Nervous System (CNS) to classify cancer registry records for clinically relevant statistical reporting. Molecular studies have identified genetic features which precisely stratify tumor types, resulting in the 2016 update to the WHO Classification incorporating these markers. To continue providing clinically relevant statistics, the histology groupings have been aligned with the 2016 update. Resulting changes to groupings were assessed. In collaboration with four consulting neuropathologists the scheme was reviewed and realigned to the 2016 update. Obsolete histology nomenclature and ICD-O-3 codes were identified. Evaluation of the frequency of affected codes in the 2013-2017 data was conducted. 417,767 total cases of primary brain and CNS tumors were diagnosed during 2013-2017 in the US. After review of the CBTRUS grouping scheme, 67 codes were noted to be obsolete, 51 codes were re-classified and 12 new codes were incorporated. This reorganization could result in grouping assignment or reporting changes for 2,588 cases (0.6%). The histology groups most significantly affected were mesenchymal tumors and neuronal and mixed neuronal glial tumors. The 2016 revision to WHO Classification has affected collection and reporting of CNS tumors. The CBTRUS data edits program is now undergoing revision, which will become the basis of reporting. Some histology-specific molecular markers require additional data to distinguish between cases. In collaboration with CBTRUS, the NAACCR SSDI Committee developed a new variable for collection of molecular information. This variable was included in Uniform Data Standards beginning on January 1, 2018 and will be available for reporting in 2021. A 2021 update to the WHO Classification is scheduled for release later this year, requiring further classification updates.
Bend loss measurements on high numerical aperture single-mode fibers as a function of wavelength and bend radius

The results of an investigation into the bend loss as a function of wavelength for single-radius bends in monomode fibers are given. The fibers considered have a high numerical aperture and a protective coating which has a refractive index greater than that of the cladding. For these fibers the pure bend loss is shown to be the dominant loss mechanism over the wavelength range 633-1152 nm. In addition, oscillations in the loss are observed as the bend radius is varied at the longer wavelengths. These oscillations are shown to result from the coupling of light under weak coupling conditions from a whispering gallery mode in the cladding formed by the pure bend loss, to the fundamental mode in the core. An expression is derived which relates the bend radius at which the minima in the oscillations occur to the fiber parameters and a qualitative explanation is given for the reduction in the oscillation amplitude as the bend radius and wavelength are decreased. A criterion is identified for assessing the strength of the coupling between the whispering gallery mode and fundamental mode. Using this criterion the attenuation coefficient of the pure bend loss at which a transition from weak to strong coupling occurs is determined and is found to agree with observations. The effect of the coupling strength between the whispering gallery mode and the fundamental mode on the characteristics of the pure bend loss is discussed. Finally, possible applications arising from the results of this work are identified.
Homotopy Perturbation Elzaki Transform Method for Obtaining the Approximate Solutions of the Random Partial Differential Equations

The series solutions of the random nonlinear partial differential equations have been examined by a hybrid method. The random nonlinear partial differential equations are studied by both normal and uniform distributions. Two initial-value problems are indicated to exemplify the influence of the solutions acquired by the hybrid method. Also, the functions for the first and second moments of the approximate solutions of random nonlinear partial differential equations are acquired in the MAPLE software. The hybrid method is implemented to analyze the solutions of the random nonlinear partial differential equations. MAPLE software is used to find the solutions. Besides, MAPLE software is used for the drawing the figures. Received: 23 Sep 2020 Accepted: 22 Sep 2021
(Invited) The new CMC standard compact MOS model PSP: advantages for RF applications

First the surface-potential-based compact MOS model, PSP, is introduced. After a discussion of the general advantages of this model, it is benchmarked against measurements from the 45 nm technology node. Finally, we zoom in on the modeling in PSP of two effects that are of special importance for RF applications: distortion and noise.
HVDC transmission for large offshore wind farms

Onshore and offshore wind farms are a rapidly growing worldwide industry. The development of larger, more efficient turbines is opening up new frontiers in wind energy generation in the form of large offshore wind farms. The use of high-voltage direct current (HVDC) technology can fully realise the potential of these developments, overcoming the major technical challenges facing traditional AC solutions and providing an efficient, economic and reliable solution.
Aeroelastic control of non-rotating and rotating wings using the dynamic stiffness modulation principle via piezoelectric actuators

Carleton University’s Rotorcraft Research Group is working on the development of an active rotor control system that incorporates a mechanism for helicopter blade pitch dynamic stiffness modulation at the root, the Active Pitch Link. This system overcomes stroke limitations of smart material and attains superior performance for helicopter rotor-induced vibration reduction. The system was tested at the whirl tower facility and this article reports the achievements obtained with a dynamically similar hinged rotor blade model. Up to 100% reduction in the transmitted loads occurred at the target 2/rev frequency when the blade was excited by a transversal jet to mimic the asymmetric flow of the helicopter rotor in forward flight. An open-loop control algorithm optimized to a target higher-harmonic frequency of the rotor also minimized the impact on the rotor fundamental cyclic control frequency at 1/rev. In another experiment at University of São Paulo, semi-passive control techniques using shunted piezoelectric materials were investigated for the aeroelastic control of fixed wings. Flutter oscillations of a typical section were controlled out over a range of airflow speeds. Finally, the similarity between both control techniques is discussed and recognized that they are based on a dynamic stiffness modulation control principle.
Title: New Parents’ Idealistic Expectations of Parenthood: The Impact of Preconceived Ideas

Parenthood is a significant life transition with considerable impacts on parent, child and family wellbeing. While life-enhancing, it is also stressful. New parents’ often hold unrealistic expectations and do not prepare adequately for the new role. Applying a critical exploratory Grounded Theory approach, this study explores the reasons for expectant parents’ unrealistic expectations. Thirty parents were interviewed about their preconceptions of parenthood, how they impacted on early parenting experiences and what, if anything, might help better prepare parents for this role. Participants reported unrealistic expectations, a lack of preparation, and recommended that parenting information be provided by professionals prenatally to help prevent adverse effects. In addition, we advocate promoting critical thinking to help parents identify and grapple with facets of social life that support and impede the way they experience and cope with parenthood, leading to the capacity to challenge cultural pressures that may make parenting even more difficult.
Power law correlations for gas/liquid flow in a flexible pipeline simulating terrain variation

The problem of prediction of the pressure drop in gas-liquid pipelines in oil reservoir applications are compounded by the fact that such pipelines generally are not straight; they go up and down, this way and that. To simulate such terrain variations we built a flexible tygon tube pipeline. This paper reports the results of experiments in this pipeline. In the general study of gas-liquid flow, flow regime transitions are identified and then pressure gradient models for each flow regime are derived. These models are used in simulators to guide field operations in gas-liquid pipelines; the models are not accurate, they are expensive to implement and certainly not suitable for pipelines in complicated configurations in which different flow regimes are simultaneously present. An alternative is to get the pressure gradient and holdup predictions directly from a systematic processing of real data for correlations; this procedure is used here. We processed data from gas/liquid flows in our flexible flow loop using mineral oil and air for four different elevation profiles. We found correlations for liquid holdup and friction factors as a function of the liquid Reynolds number ReL = UL D/DL and flow rate fraction = QG /(QG+QL) in each configuration. An overall correlation for the holdup and friction factor using all the data from all four elevation profiles was also obtained. The overall correlations are of course less accurate but are proposed for the typical situation in which the elevation profile for a particular pipeline is not known or is not available. The holdup correlations are in the form s l r L e h
Increased risk of thyroid dysfunction by PD-1 and CTLA-4 blockade in patients without thyroid autoantibodies at baseline.

BACKGROUND Previous studies showed that although the risk of thyroid dysfunction (thyroid immune-related adverse events [irAEs]) induced by anti-programmed cell death-1 antibodies (PD-1-Ab) was as low as 2-7% in patients negative for anti-thyroid-antibodies (ATAs) at baseline, it was much higher (30-50%) in patients positive for ATAs. However, whether a similar increase occurs with combination therapy using PD-1-Ab plus anti-cytotoxic T-lymphocyte antigen-4 antibody (CTLA-4-Ab) is unknown. METHODS A total of 451 patients with malignancies treated with PD-1-Ab, CTLA-4-Ab, or a combination of PD-1-Ab plus CTLA-4-Ab (PD-1/CTLA-4-Abs) were evaluated for ATAs at baseline and for thyroid function every 6 weeks for 24 weeks after treatment initiation, and then observed until the last clinical visit. RESULTS Of the 451 patients, 51 developed thyroid-irAEs after immunotherapy [41 of 416 (9.9%) treated with PD-1-Ab, 0 of 8 (0%) with CTLA-4-Ab, and 10 of 27 (37.0%) with PD-1/CTLA-4-Abs]. The cumulative incidence of thyroid-irAEs was significantly higher in patients who were positive versus negative for ATAs at baseline after both PD-1-Ab [28/87 (32.2%) vs. 13/329 (4.0%), p < 0.001] and PD-1/CTLA-4-Abs [6/10 (60.0%) vs. 4/17 (23.5%), p < 0.05] treatments. The risk of thyroid-irAEs induced by PD-1/CTLA-4Abs, which was significantly higher than that induced by PD-1-Ab, in patients negative for ATAs at baseline was not statistically different from that induced by PD-1-Ab in patients positive for ATAs at baseline. CONCLUSIONS This study showed that the incidence of thyroid-irAEs was high and not negligible after PD-1/CTLA-4-Abs treatment even in patients negative for ATAs at baseline.
Class E Power Amplifiers and Frequency Multipliers with finite DC-Feed Inductance

Previous descriptions of class E amplifiers and frequency multipliers have required a radio frequency choke between the dc power supply and the active device "switch. " In this paper, it is shown that class E operation may be maintained with the RF choke replaced by a smaller reactance. The analysis technique used is similar to that used by Raab in his description of class E amplifiers in that the equations describing circuit operation are obtained from Fourier series methods and the assumption of an infinite output network Q . The equations so obtained are used to determine (1) optimum operation (maximum power output capability at 100-percent efficiency) at any harmonic and (2) design equations that yield the requisite component values for optimum operation. The equations show that class E circuits may be configured to accommodate devices with arbitrary output capacitance and that class E amplifiers may be configured to provide greater power output capability than can be obtained using an RF choke design. Class E circuits with moderate values of output network Q were constructed and tested. The measured performance of these experimental circuits shows excellent agreement with the theoretical performance predicted by the equations.