Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Plants Belong to Cruciferous Family as an Anti-Cancer Agent

Introduction: Cancer is still one of the most prime causes of mortality and claims over 6 million deaths worldwide. Scientists are giving their best to confront this disease; however, the sure-shot cure is still awaited. Although there are so many options for the treatment of cancer but they all have certain side effects. Nowadays, scientists are keener to know about the complementary and alternative plantderived natural medicine for treating cancer with minimum side effects. Various epidemiological studies done by scientist provide evidence that Cruciferous vegetables are rich source of nutrients and phytochemicals that may work symbiotically to help avert the risk of cancer in humans. The present review explores the various studies done in this topic to gather more relevant information and knowledge regarding the subject. Method: Extensive electronic search was done to collect relevant studies from PubMed, Cochrane and EMBASE etc. and then analyzed and summarized here for the benefit of readers interested to do further studies on the anti-cancerous properties of plants belonging to cruciferous family. Result: Several studies have demonstrated the protective and anti-cancerous activities of cruciferous plants and these are highly recommended as a preventive diet especially for breast cancer, stomach cancer and pancreatic cancer.
Recollection Skills of Television Advertisement among Secondary School Students in Makurdi, Benue State, Nigeria

Quite a reasonable number of practitioners and scholars in advertising and sales promotion hold the view that there is no more dynamic and fascinating a field to either practice or study. Media advertising seems to be the most visible part of a firm's promotional program. Our television screens are full of advertisements. Promotion, especially using advertisement, gulps large chunk of many companies budget. Unfortunately, most marketing managers that engage in product advertisement find it difficult determining the effect, impact or contributions of huge advertisement expenditure on the overall business growth and performance of their organizations. Going by the fact that purchase action can be initiated when the brain retrieves and releases product information acquired and stored during advertisement, we therefore postulate that the ability of an individual to take rigorous purchase decision based on advertisement exposure is dependent on his/her recollection and retention skills. This study, therefore, attempts to determine the recollection skills of television advertisement among secondary school students in Nigeria. Specifically the study seeks to find out if the length (in this case, duration) of a television advertisement has significant relationship with its recollection. The study equally attempts to ascertain if the repetition of a television advertisement has any direct relationship with its retention. Findings from the study show that the duration of a TV advert has significant relationship with its recollection and that repetition of TV adverts enhances their retention.
Investigation on Open-winding PMSG System Fed by Three Level NPC Converter and Diode Converter

In medium and high voltage application, NPC topology has been widely investigated concerning the modulation strategies and control methods. Meanwhile, the open winding configuration is gaining the increasing attention in large power drive field. The semi-controlled open winding PMSG system with the integration of three-level full controlled voltage source converter (VSC) and uncontrolled diode converter will be investigated in this paper. The proposed semi-controlled open winding PMSG system has less switch losses, simpler system configuration and still inherits the advantage of traditional open-winding configuration such as the multilevel modulation effect. Based on the mathematical model of the semi-controlled open winding PMSG system, the control scheme is proposed, which is based on the vector control with rotor flux orientation. Finally, a simulation is built to validate the theoretical investigation on the open winding PMSG system.
Transitioning to a high renewable net-zero power generation system in Malaysia

Malaysia is a net importer of coal, petroleum products and piped natural gas. Moreover, its primary energy supply is dominated by fossil fuels, at about 93% in total, with coal and natural gas constituting the highest shares in electricity generation. Thus, there is need for Malaysia to take swift action in transitioning to a high renewable energy system for long-term sustainability and meeting its climate action commitment under the Paris Agreement. A net-zero emissions vision guided by a roadmap may effectively motivate and catalyse carbon-free energy deployments. In this paper, we revisit the carbon-free energy roadmap that was developed in 2015 and compare it with the current generation development plan to identify the gaps between them. We argue that the roadmap is still relevant to the net-zero emissions vision; however, we have also identified gaps that merit further research and improvement. The identified gaps mainly relate to more recent data, along with technology and policy developments. Accordingly, we put forward potential research suggestions to bridge these gaps for future development of a roadmap that would assist Malaysia in shaping a long-term plan towards realizing a high renewable net-zero power generation system. This article is part of the theme issue ‘Developing resilient energy systems’.
Effectiveness of the BNT162b2 vaccine among children 5-11 and 12-17 years in New York after the Emergence of the Omicron Variant

Importance: There is limited evidence on the effectiveness of the BNT162b2 vaccine for children, particularly those 5-11 years and after the Omicron variant's emergence. Objective: To estimate BNT162b2 vaccine effectiveness against COVID cases and hospitalizations among children 5-11 years and 12-17 years during December, 2021 and January, 2022. Design: Analyses of cohorts constructed from linked statewide immunization, laboratory testing, and hospitalization databases. Setting/Participants: New York State children 5-17 years. Main outcomes/measures: New laboratory-confirmed COVID-19 cases and hospitalizations. Comparisons were made using the incidence rate ratio (IRR), comparing outcomes by vaccination status, and estimated vaccine effectiveness (VE: 1-[1/IRR]). Results: From December 13, 2021 to January 30, 2022, among 852,384 fully-vaccinated children 12-17 years and 365,502 children 5-11 years, VE against cases declined from 66% (95% CI: 64%, 67%) to 51% (95% CI: 48%, 54%) for those 12-17 years and from 68% (95% CI: 63%, 72%) to 12% (95% CI: 6%, 16%) for those 5-11 years. During the January 24-30 week, VE for children 11 years was 11% (95%CI -3%, 23%) and for those age 12 was 67% (95% CI: 62%, 71%). VE against hospitalization declined changed from 85% (95% CI: 63%, 95%) to 73% (95% CI: 53%, 87%) for children 12-17 years, and from 100% (95% CI: -189%, 100%) to 48% (95% CI: -12%, 75%) for those 5-11 years. Among children newly fully-vaccinated December 13, 2021 to January 2, 2022, VE against cases within two weeks of full vaccination for children 12-17 years was 76% (95% CI: 71%, 81%) and by 28-34 days it was 56% (95% CI: 43%, 63%). For children 5-11, VE against cases declined from 65% (95% CI: 62%, 68%) to 12% (95% CI: 8%, 16%) by 28-34 days. Conclusions and Relevance: In the Omicron era, the effectiveness against cases of BNT162b2 declined rapidly for children, particularly those 5-11 years. However, vaccination of children 5-11 years was protective against severe disease and is recommended. These results highlight the potential need to study alternative vaccine dosing for children and the continued importance layered protections, including mask wearing, to prevent infection and transmission.
Gendering the everyday state: Muslim women, claim-making & brokerage in India

ABSTRACT This ethnographic article focuses on interactions between poor Muslim women, various intermediaries/brokers, and the Indian state. The article illustrates the complexities of claim-making and the forms of subjugation/marginalisation Muslim women experience when attempting to access resources, documents or paperwork. Contrary, however, to many representations of Muslim women’s engagements with the state, we also draw out agentive aspects as women hustle and negotiate to make claims and assert citizenship rights. Outcomes are variegated but also incorporate some women in brokerage roles, challenging assumptions regarding state/people mediation in India which foregrounds male brokers. The empirical detail is situated in a theoretical context incorporating gendered distinctions between shifting imaginaries of ‘nation’ and lived experiences of the ‘everyday state’. In a context where ‘nation’ has been evoked and articulated as a feminine form – through evocations of mata (mother) – we show how shifts towards a masculine imaginary, symbolised within Hindu-nationalist discourses, impacts Muslim women’s subjective experiences. We also illustrate that, whilst gendered imaginaries of ‘the nation’ are shifting, the ‘everyday state’ has long been experienced as a masculinised formation. Here we show how embodied involvements with the everyday state were constituted through gendered bureaucratic histories, spatial configurations, urban cosmologies and broader ideologies.
Nr2f1a maintains atrial nkx2.5 expression to repress pacemaker identity within venous atrial cardiomyocytes of zebrafish

Maintenance of cardiomyocyte identity is vital for normal heart development and function. However, our understanding of cardiomyocyte plasticity remains incomplete. Here, we show that sustained expression of the zebrafish transcription factor (TF) Nr2f1a prevents the progressive acquisition of ventricular cardiomyocyte (VC) and pacemaker cardiomyocyte (PC) identities within distinct regions of the atrium. Transcriptomic analysis of isolated atrial cardiomyocytes (ACs) from nr2f1a mutant zebrafish embryos showed increased VC marker gene expression and altered expression of core PC regulatory genes, including decreased expression of nkx2.5, a critical repressor of PC differentiation. At the arterial pole of the atrium in nr2f1a mutants, cardiomyocytes resolve to VC identity within the expanded atrioventricular canal. However, at the venous pole, there is a progressive wave of AC transdifferentiation into PCs across the atrium toward the arterial pole. Restoring Nkx2.5 is sufficient to repress PC identity in nr2f1a mutant atria and analysis of chromatin accessibility identified a Nr2f1a-dependent nkx2.5 enhancer expressed in the atrial myocardium directly adjacent to PCs, supporting that Nr2f1a limits PC differentiation within venous ACs via maintaining nkx2.5 expression. The Nr2f-dependent maintenance of AC identity within discrete atrial compartments may provide insights into the molecular etiology of concurrent structural congenital heart defects and associated arrhythmias.
Microcompartment assembly around multicomponent fluid cargoes

This article describes dynamical simulations of the assembly of an icosahedral protein shell around a bi-component fluid cargo. Our simulations are motivated by bacterial microcompartments, which are protein shells found in bacteria that assemble around a complex of enzymes and other components involved in certain metabolic processes. The simulations demonstrate that the relative interaction strengths among the different cargo species play a key role in determining the amount of each species that is encapsulated, their spatial organization, and the nature of the shell assembly pathways. However, the shell protein-protein and shell-cargo interactions that help drive assembly and encapsulation also influence cargo composition within certain parameter regimes. These behaviors are governed by combination of thermodynamic and kinetic effects. In addition to elucidating how natural microcompartments encapsulate multiple components involved within reaction cascades, these results have implications for synthetic biology efforts to colocalize alternative sets of molecules within microcompartments to accelerate reactions. More broadly, the results suggest that coupling between self-assembly and multicomponent liquid-liquid phase separation may play a role in organization of the cellular cytoplasm.
Prediction of Split Renal Function Improvement After Renal Artery Stenting by Blood Oxygen Level–Dependent Magnetic Resonance Imaging

Background The discrepancy between the high technical success rate and the relatively low clinical response rate of renal artery stenting (RAS) raises the importance to identify atherosclerotic renal artery stenosis (ARAS) patients who are most likely to benefit from RAS. This study aimed to investigate the feasibility and accuracy of blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) in predicting split renal function (SRF) improvement after RAS in patients with ARAS. Methods Thirty patients with severe ARAS who were treated with RAS were enrolled. Baseline cortical and medullary R2* values of each kidney were measured by BOLD-MRI, and each patient’s SRF was evaluated by nuclear renal dynamic imaging at baseline and 1-month follow-up. Results In total, 35 severe stenotic renal arteries of the 30 patients were analyzed. At 1-month follow-up, 34 kidneys (97.1%) of severe ARAS had acquired SRF. SRF improved in 12 kidneys of 10 patients. The cortical R2* and medullary R2* values in the SRF improvement kidneys were higher than those in the non-improvement kidneys (P ≤ 0.001). The area under the curve of medullary R2* was 0.879 (95% confidence interval [CI] 0.736–1.000). A medullary R2* value ≥29.1 s–1 was noted to provide good sensitivity (0.833, 95% CI 0.552–0.970) and specificity (0.864, 95% CI 0.667–0.953) in predicting SRF improvement. Medullary R2* value was the only independent predictor of SRF improvement in multivariable analysis (P = 0.034, OR 3.017, 95%CI 1.089–8.358). Conclusion This study showed that a BOLD-MRI medullary R2* value ≥29.1 s–1 was an excellent predictor of SRF improvement in patients with severe ARAS who underwent renal artery stenting.
In vitro Evaluation of the Anti-hypercholesterolemic Effect of Lactobacillus Isolates From Various Sources

The anti-hypercholesterolemic effect of 11 Lactobacillus isolates was investigated in vitro by measuring remaining cholesterol in growth media, growth ability in media supplemented with cholesterol, and BSH activity. Among the selected isolates, DLBSH104, DLBSH122, and DLBSK207 have demonstrated outstanding potential as cholesterol-lowering cultures. The three isolates showed high cholesterol removal by growing cells, whereas resting and dead cells showed less cholesterol removal. Furthermore, visualization of those isolates in growing and non-growing states by SEM showed the ability of DLBSH104 to attach cholesterol to their cell surface. In contrast, alteration of DLBSH122 and DLBSK207 cells did not involve surface attachment of cholesterol. Thus, the isolates’ ability to remove cholesterol is mainly attributed to the cells’ metabolically active state that assimilates and incorporates cholesterol into the cell membrane as reflected by a significantly higher cholesterol removal in a growing state than a non-growing state. Only in DLBSH104 did cholesterol removal also involve attachment on the cell surface. Moreover, DLBSH104 has beneficially affected the host cell by a significant reduction of NPC1L1 mRNA levels that are responsible for intestinal cholesterol absorption. In hepatic cells, cell-free supernatant (CFS) from DLBSH104 and DLBSK207 were able to reduce LDLR and HMGCR mRNA at the transcription level. To sum up, L. helveticus DLBSH104 and L. plantarum DLBSK207 are confirmed as isolates with an anti-hypercholesterolemic effect.
Speciation of Genes and Genomes: Conservation of DNA Polymorphism by Barriers to Recombination Raised by Mismatch Repair System

Some basic aspects of human and animal biology and evolution involve the establishment of biological uniqueness of species and individuals within their huge variety. The discrimination among closely related species occurs in their offspring at the level of chromosomal DNA sequence homology, which is required for fertility as the hallmark of species. Biological identification of individuals, i.e., of their biological “self”, occurs at the level of protein sequences presented by the MHC/HLA complex as part of the immune system that discriminates non-self from self. Here, a mechanistic molecular model is presented that can explain how DNA sequence divergence and the activity of key mismatch repair proteins, MutS and MutL, lead to 1) genetic separation of closely related species (sympatric speciation) (Fitch and Ayala, Proceedings of the National Academy of Sciences, 1994, 91, 6717–6720), 2) the stability of genomes riddled by diverged repeated sequences, and 3) conservation of highly polymorphic DNA sequence blocks that constitute the immunological self. All three phenomena involve suppression of recombination between diverged homologies, resulting in prevention of gene sharing between closely related genomes (evolution of new species) as well as sequence sharing between closely related genes within a genome (e.g., evolution of immunoglobulin, MHC, and other gene families bearing conserved polymorphisms).
Light Triggered Enhancement of Antibiotic Efficacy in Biofilm Elimination Mediated by Gold-Silver Alloy Nanoparticles

Bacterial biofilm is a tri-dimensional complex community of cells at different metabolic stages involved in a matrix of self-produced extracellular polymeric substances. Biofilm formation is part of a defense mechanism that allows the bacteria to survive in hostile environments, such as increasing resistance or tolerance to antimicrobial agents, causing persistent infections hard to treat and impair disease eradication. One such example is bovine mastitis associated with Streptococcus dysgalactiae subsp. dysgalactiae (SDSD), whose worldwide health and economic impact is on the surge. As such, non-conventional nanobased approaches have been proposed as an alternative to tackle biofilm formation and to which pathogenic bacteria fail to adapt. Among these, metallic nanoparticles have gained significant attention, particularly gold and silver nanoparticles, due to their ease of synthesis and impact against microorganism growth. This study provides a proof-of-concept investigation into the use of gold-silver alloy nanoparticles (AuAgNPs) toward eradication of bacterial biofilms. Upon visible light irradiation of AuAgNPs there was considerable disturbance of the biofilms’ matrix. The hindering of structural integrity of the biofilm matrix resulted in an increased permeability for entry of antibiotics, which then cause the eradication of biofilm and inhibit subsequent biofilm formation. Additionally, our results that AuAgNPs inhibited the formation of SDSD biofilms via distinct stress pathways that lead to the downregulation of two genes critical for biofilm production, namely, brpA-like encoding biofilm regulatory protein and fbpA fibronectin-binding protein A. This study provides useful information to assist the development of nanoparticle-based strategies for the active treatment of biofilm-related infections triggered by photoirradiation in the visible.
Ex Vivo Near-Infrared Molecular Imaging of Human Upper Urinary Tract Urothelial Carcinoma With a CD47-Based Targeted Tracer

Objective The low detection rate of early and small tumors remains a clinical problem that urgently needs to be solved in the accurate diagnosis and treatment of upper urinary tract urothelial carcinoma (UTUC). The objective of this study is to evaluate the feasibility of CD47 as a target for optical molecular imaging of human UTUC and conduct preliminary ex vivo imaging experiments. Methods We firstly analyzed the genome-wide mRNA expression data from Gene Expression Omnibus (GEO). Paraffin-embedded tissue specimens comprising UTUC and normal urothelium were collected. All tissue specimens were used for immunohistochemistry to compare CD47 protein expression in normal and cancer tissue. Meanwhile, 12 patients undergoing radical nephroureterectomy were prospectively included in ex vivo imaging experiments. Freshly isolated upper urinary tract specimens were incubated with anti-CD47-Alexa Fluor 790 and then imaged under white light and near-infrared (NIR) light. Standard histopathologic evaluation was performed, and findings were correlated with CD47-targeted NIR molecular imaging. Results The GEO data revealed that CD47 mRNA expression was higher in UTUC specimens than that in paracancer normal tissue. In immunohistochemical analysis, the CD47 protein expression level was higher in both non-muscle-invasive and muscle-invasive (stage ≥T2) UTUCs than that in normal uroepithelium, and the localization of CD47 protein was the tumor cell membrane. In the ex vivo imaging experiments, all patients were pathologically diagnosed with UTUC, and no adverse effects of anti-CD47-Alexa Fluor 790 on the histological structure of the tumor and normal uroepithelium were observed. In the NIR grayscale images, the mean fluorescence intensity of the tumor tissue was significantly higher than that of the adjacent normal background tissue, which greatly improved the visualization of the tumor. Conclusions CD47-targeted NIR molecular imaging could be a feasible and powerful strategy for the accurate diagnosis of UTUC. Larger-scale randomized trials are needed.
Application of Anesthetics in Cancer Patients: Reviewing Current Existing Link With Tumor Recurrence

Surgery remains the most effective cancer treatment, but residual disease in the form of scattered micro-metastases and tumor cells is usually unavoidable. Whether minimal residual disease results in clinical metastases is a function of host defense and tumor survival and growth. The much interesting intersection of anesthesiology and immunology has drawn increasing clinical interest, particularly, the existing concern of the possibility that the perioperative and intraoperative anesthetic care of the surgical oncology patient could meaningfully influence tumor recurrence. This paper examines current data, including recent large clinical trials to determine whether the current level of evidence warrants a change in practice. Available pieces of evidence from clinical studies are particularly limited, largely retrospective, smaller sample size, and often contradictory, causing several questions and providing few answers. Recent randomized controlled clinical trials, including the largest study (NCT00418457), report no difference in cancer recurrence between regional and general anesthesia after potentially curative surgery. Until further evidence strongly implicates anesthesia in future clinical trials, clinicians may continue to choose the optimum anesthetic-analgesic agents and techniques in consultation with their cancer patients, based on their expertise and current best practice.