Miracle-dz/UniFAR-FTUs huggingface dataset:
An In Vitro Model of Early- or No-Reperfusion Scars to Explain Reentrant Arrhythmia Characteristics May Relate to Therapeutic Efficacy

Purpose: Early-reperfusion during acute myocardial infarction causes scars with a patchy aspect, whereas no reperfusion causes compact scars. Patchy scars show a lower inducibility and shorter cycle length of arrhythmias compared to compact scars. Despite increasing numbers of early-reperfused patients, little data on arrhythmic mechanisms is available. We therefore developed an in vitro model of patchy and compact scar patterns to gain a mechanistic understanding of associated arrhythmia characteristics and how these affect the efficacy of anti-arrhythmic interventions. Methods: Neonatal rat Ventricular monolayers were locally ablated at day 6-7 of culture by a laser-cut plexiglass stamp that produced an anatomical obstruction to mimic a compact scar or a stamp that produced multiple smaller anatomical obstructions with an equal total outer obstruction diameter to mimic patchy scars. One day later, optical mapping was performed. Results: Inducibility of reentry was slightly lower in patchy cultures compared to compact cultures (41%, n=34 vs 52%, n=23, P <0.05) and cycle length of reentry was shorter (234±52 vs 288±38 ms, P <0.05). Reentry was less frequently sustained in patchy cultures (40% vs 88% in compact cultures) while the percentage of complex arrhythmias was higher (31% vs 11%). Meandering was only found in patchy cultures and could result in local polymorphic pseudo-electrograms. A gradient of excitability during reentrant arrhythmias was only detectable in patchy cultures. Termination of reentry by electrical stimulation was more easily achieved in compact cultures (82% vs 20% in patchy cultures) while Nav1.5 blockade by tetrodotoxin only induced meandering in patchy cultures (67% of arrhythmic cultures). In smaller cultures, this resulted in more frequent termination of reentry in patchy cultures. Conclusions: An in vitro model of patchy and compact obstructions reproduces arrhythmic characteristics observed after early- and non-reperfused myocardial infarctions. Furthermore, it may provide mechanistic
FOXA1 in Mouse Hepatic Estrogen Receptor α Signaling

The aim of this study was to investigate the role and interaction of FOXA1 with ERα in normal mouse liver. RNA interference was used to silence FOXA1 expression in mouse liver, and ERα-chromatin interaction and ERα-dependent transcription were studied both in the presence and absence of an estrogenic stimulus. The genes that were selected for analysis were hepatic (expressed in liver) estrogen-responsive genes including genes of the blood coagulation pathway and hepatic genes that previously were demonstrated to be affected by FOXA proteins. The results showed that FOXA1 had the ability to alter hepatic gene expression independent of estrogen hormone in mouse liver. We also showed that silencing of hepatic FOXA1 inhibited 17β-ethinylestradiol (EE)-bound ERα chromatin binding for a panel of representative hepatic genes. However, despite the modulatory potential of FOXA1 on chromatin binding, FOXA1 silencing did not alter estrogen-induced transcriptional changes of a panel of representative hepatic genes under the present study conditions.
NUMERICAL INVESTIGATION OF AXIAL STRENGTH DEVELOPMENT IN METAL SHEET CONFINED CONCRETE

This paper computationally investigated behavior of metal sheet confined concrete specimens subjected to axial compression . To understand mechanisms that occurred in the metal sheet confinement system during the loading, plain concrete specimens confined with 1 - 3 layers of metal sheet were analyzed via the three dimensional finite element analysis . Cylindrical and square cuboid concrete specimens of the same cross sectional area were selected to understand effect of specimen shapes on axial compression behavior of metal sheet confined specimens . The numerical results showed that the metal sheet confinement system could improve axial compression capacity of all the specimens . The improved stress - strain behavior of the specimens was not influenced by lateral confinement only, but also by ability of metal sheet in resisting axial compression . It was observed that shape and number of layers of confinement affected the strength increase . For two layers of metal sheet application, slightly different behaviors were found at the inner and the outer jackets . For the cuboid specimen, different behaviors at the region near the corner and on the side were noticed . The non - uniform stress distribution across the square section led to lower axial strength improvement when applying the same number of metal sheet layers, as compared to the circular section .
A generalized finite difference approach to the computation of modes

This thesis deals with numerical techniques for the computation of modes in electromagnetic structures with arbitrary geometry. The approach proposed in this work is based on the Finite Difference (FD) and Vector Finite Difference (VFD), which are applied to rectangular, circular, elliptical geometries, and to combination of them. The FD is applied using a 2D cartesian, polar and elliptical grid in the waveguide section. A suitable Taylor expansion of the mode function allows, either for scalar and for vector FD, to take exactly into account the boundary condition. To prevent the raising of spurious modes, the VFD approximation results in a constrained eigenvalue problem, that has been solved using a decomposition method. All approaches presented have been validated comparing the results to the analytical modes of rectangular and circular waveguide, and to known data for the elliptic case. The standard calculation of the waveguide modes using FD requires the use of two different grids, namely one for TE modes and the other for TM modes, due to the different boundary condition. It has been shown that a single grid can be used for all modes, thus allowing an effective mode-matching solution. The FD approach has been extended to waveguides (and apertures) with irregular boundaries, and therefore non-regular discretization grids. It has been shown that a suitable FD approximation of the Laplace operator is still possible. A ridged-waveguide, with trapezoidal ridges, and a rounded-ended waveguide have been considered in detail.
RESEARCH Inﬂammation and Inﬂammatory Mediators in Kidney Disease Greater transforming growth factor- (cid:2) in adult female SHR is dependent on blood pressure, but does not account for sex differences in renal T-regulatory cells

transforming growth factor- (cid:2) in adult female SHR is dependent on blood pressure, but does not account for sex differences in renal T-regula-tory cells. Am J Physiol Renal Physiol 313: F847–F853, 2017. spontaneously hypertensive rats (SHR) have more renal regulatory T cells (Tregs) than males, and greater levels of Tregs in female SHR are dependent on blood pressure (BP). However, the molecular mechanism responsible for greater Tregs in female SHR is unknown. Transforming growth factor (TGF)- (cid:2) is a pleiotropic cytokine critical in the differentiation of naïve T cells into Tregs, and female SHR have higher TGF- (cid:2) excretion than male SHR. The goals of the current study were to test the hypotheses that 1 ) female SHR have greater renal TGF- (cid:2) expression than male SHR, which is dependent on BP and 2 ) neutralizing TGF- (cid:2) will decrease renal Tregs in female SHR. Renal cortices were isolated from 5- and 13-wk-old male and female SHR, and TGF- (cid:2) levels were measured via Western blot and ELISA. Adult female SHR have more free, active TGF- (cid:2) 1 than 5-wk-old female SHR (46% more) or male SHR (44% more than 5-wk-old males and 56% more than 13-wk-old male SHR). We conﬁrmed greater TGF- (cid:2) 1 in adult female SHR was due to increases in BP and not sexual maturation by measuring TGF- (cid:2) 1 levels following treatment with BP-lowering drugs or ovariectomy. Separate female SHR were treated with an antibody to TGF- (cid:2) 1,2,3 ; BP was measured, and T cells were assessed in whole blood and the kidney. Neutralizing TGF- (cid:2) had no effect on BP, although circulating Tregs decreased by 32%, while Th17 cells increased by 64%. Renal Tregs were not altered by antibody treatment, although Th17 cells were decreased by 61%. In conclusion, although TGF- (cid:2) promotes circulating Tregs in female SHR, it does not account for the sex difference in renal Tregs in SHR.
Ischemic stroke as a rare cause of seizures in a newborn – case report

Background: Identifying etiology of seizures is the primary clinical objective in the management of neonatal seizures (NS). About 85 % of NS cases occurr as a consequence of a specific, identifiable etiology. Causes of symptomatic NS can be broadly categorized as: hypoxic-ischemic encephalopathy, electrolyte or metabolic disturbances, CNS or systemic infections, developmental defects and acquired structural brain lesions, including hemorrhagic or ischemic stroke. Ischemic stroke is characterized as a sudden focal or generalized brain function disruption, whose symptoms tend to last longer than 24 hours (or cause death) and have no other reason but a vascular one. The reported annual incidence is estimated at one per 4000 live births for neonates. in in apparently patient to the Department of Neonate and Infant Pathology. Shortly after arrival the seizures appeared again. Laboratory tests showed slightly lowered glucose level and elevated serum concentration of lactic acid. The ultrasound examination of the head revealed a small right-sided subependymal cyst. The patient’s condition was deteriorating, with recurring righ-sided clonic and tonic seizures accompanied by apnea and desaturation that required resuscitation efforts. Because of worsening state of the patient, CT scan was performed. The CT examination revealed a hypodensic area in the left parietal region and cerebral edema, which indicated a possible ischemic stroke. Conclusions: The absence of visible pathologies in the ultrasound examination of the head does not necessarily indicate a lack of CSN abnormalities. More precise imaging tests are needed to identify the cause of NS.
Omics Interrogation of Primary Sclerosing Cholangitis

Ahmad Hassan Ali Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN Brian D. Juran Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN Erik M. Schlicht Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN Jackie K. Bianchi Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN Bryan M. McCauley Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN Elizabeth J. Atkinson Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN Konstantinos N. Lazaridis (  lazaridis.konstantinos@mayo.edu ) Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN
On Key Evolution over Wireless Channels

Noise is a powerful resource for the implementation of cryptographic primitives, especially in wireless networks. In general, a key agreement protocol is tailored to the channels and relies on the assumption that knowledge on the eavesdropper's channel is available. This is not practical. In this paper, we focus on the problem of developing key agreement schemes for secure communication across wireless channels and propose a key evolution scheme to alleviate the assumption. Keys evolve continuously based on the transmitted messages over the noisy wireless channel. Even if the eavesdropper's channel is superior to the legitimate receiver, the legitimate parties can establish secret keys. To further confuse the eavesdropper, we present a strategy for legitimate parties to send artificial noise if the eavesdropper cannot distinguish the sources of messages. Finally, we propose a k-resistant encryption scheme that can use different keys to encrypt and decrypt messages if there are no more than k bits which differ between the encryption and decryption keys.
The Validity of Big Data: The impact on the grocery industry

Technology has enabled many applications for the grocery industry. One of them is the personal discount-card. A personal discount-card is an example of data generation and appliance. Most grocery organizations that utilize this data are larger franchises, that provide the population with provisions on a daily basis. To illustrate, one of the biggest retailers in the world serve 50 million customers a week. When data is collected on a population of this size, the amount of data can be considered as ‘Big Data’. But that poses the question: how can these organizations verify that the data collected is accurate and representative, and is therefore valid? This report will aim to fill the knowledge gap on the challenges concerning the validity of data in Big Data Analytics for the grocery industry and will present the impact validity has on Big Data Analytics, to inspire further research in developing possible countermeasures.
STARS 4 ALL Deliverable D 5 . 7 STARS 4 ALL tools for crowdsourcing activities ( initial release )

(fordissemination) This deliverable introduces a reference model for crowdsourcing activities within the STARS4ALL project; it also describes some of the software components which have been developed and customized for LPI7; the main metrics to evaluate crowdsourcing activities are illustrated; an example of result evaluation, based on the information gathered through the Night Knights game, is also included to exemplify our approach.
Effects of 17/3-estradiol and progesterone on growth-factor-induced proliferation and migration in human female aortic smooth muscle cells in vitro

Objective: The significantly low prevalence of atherosclerotic cardiovascular disease in premenopausal women has been noted, and postmenopausal hormone replacement therapy (HRT) is associated with protection from this disease. The aim of this study was to investigate the effects of estrogen and progestin on growth-factor-induced vascular smooth muscle cell (VSMC) proliferation and migration in vitro. Methods: Two cell lines of human female aortic smooth muscle cells (AOSMCs) were used for the study. DNA synthesis was evaluated by [3H]thymidine incorporation into cells. Migration assay was performed using modified Boyden chambers. Results: The presence of estrogen receptors was determined by Western and Northern blot analyses. [3H]Thymidine incorporation into AOSMCs was induced by 10 ng/ml EGF alone, the combination of 10 ng/ml EGF with 2 ng/ml b-FGF-induced and 1 nM PDGF-BB alone. Migration of AOSMCs was induced by PDGF-BB. Since 17/3-estradiol (E 2, 10 9 M ~ 10 6 M) inhibited the [3H]thymidine incorporation into AOSMCs stimulated by above mitogens and the 1 nM PDGF-BB-induced AOSMC migration in a dose-dependent manner, estrone (El), estriol (E 3) and progesterone (P) had no significant effects. The combination of P (10 -9 M ~ 10 -6 M) did not show any effect on these inhibitory effects of 10 -7 M E 2. Preincubation of AOSMCs with the anti-estrogenic agent, tamoxifen (10 6 M), significantly antagonized these inhibitory effects of 10 -7 M E 2. Conclusions: These findings suggest that the inhibitory effect of E 2 on VSMC proliferation and migration might be one of the factors involved in the decreased incidence of atherosclerotic cardiovascular disease in premenopausal women and postmenopausal HRT, and P might not affect these estrogenic responses.
Construction effective des codes geometriques

Cette these est consacree a la construction effective des codes geometriques. Le probleme essentiel pour construire de tels codes consiste a calculer une base de l'espace vectoriel associe a un diviseur d'un corps de fonctions algebriques a une variable dont le corps de base est fini. Pour ce faire, on propose d'utiliser l'algorithme de brill-noether dans le cas ou l'on connait un modele plan du corps de fonctions algebriques a une variable. L'algorithme de brill-noether necessitant souvent de considerer une extension algebrique finie du corps de base, on montre comment utiliser de facon simple et efficace les extensions dynamiques de corps finis. Afin de faciliter l'implantation sur ordinateur, l'algorithme de brill-noether et toutes ses procedures sous-jacentes sont presentes en utilisant une approche algebrique plutot que geometrique. L'aspect pratique de l'algorithme de brill-noether est mis en evidence par des exemples codes geometriques. Tous ces exemples ont ete construits a l'aide de l'implantation de l'algorithme de brill-noether realisee par l'auteur dans le systeme de calcul formel axiom. Independamment de l'algorithme de brill-noether, on propose aussi une construction effective propre a des codes geometriques definis a partir d'extensions particulieres de corps de fonctions du type d'artin-schreier.
Imaginary alternatives: The impact of mental simulation on powerless negotiators

The present research demonstrates that negotiators can act powerfully without having power. Researchers and practitioners advise people to obtain strong alternatives prior to negotiating to enhance their power. However, alternatives are not always readily available, often forcing negotiators to negotiate without much, or any, power. Building on research suggesting that subjective feelings of power and objective outcomes are disconnected and that mental simulation can increase individuals’ aspirations, we hypothesized that the mental imagery of a strong alternative could provide similar psychological benefits to having an actual alternative. Our studies demonstrate that imagining strong alternatives causes individuals to negotiate more ambitiously and provides them with a distributive advantage: negotiators reached more profitable agreements when they either had a strong tendency to think about better alternatives (Study 1) or when they were instructed to mentally simulate an attractive alternative (Studies 3-4). Mediation analyses suggest that mental simulation boosts performance because it increases negotiators’ aspirations which translate into more ambitious first offers (Studies 2-4), but only when the simulated alternative is attractive (Study 2b). Our findings further show that mental simulations are only beneficial when there is sufficient room in the negotiation to reach a profitable agreement, but backfire in settings where negotiators’ positions are difficult to reconcile (Study 5). An internal meta-analysis of the file-drawer produces effect size estimates free of publication bias and demonstrates the robustness of the effect. Our findings contribute to research on social power, negotiations, and mental simulation.
Comparison of the e cacy of radiofrequency ablation vs. liver resection in the treatment of hepatocellular carcinoma within Milan criteria with severe brosis

Lei Chen Huazhong University of Science and Technology Dongqiao Xiang Huazhong University of Science and Technology Licheng Zhu Huazhong University of Science and Technology Linxia Wu Huazhong University of Science and Technology Yanqiao Ren Huazhong University of Science and Technology Tao Sun Huazhong University of Science and Technology Weihua Zhang Huazhong University of Science and Technology Bo Sun Huazhong University of Science and Technology Yiming Liu Huazhong University of Science and Technology Chuansheng Zheng (  hqzcsxh@sina.com ) Huazhong University of Science and Technology
Ultrastructure of the Seminiferous Epithelium of Prairie Deer Mice (Peromyscus maniculatus Bairdii) from a Freely-Growing, Confined Population

Kale prairie deer mice (Per orgy sous manlculatus bairdll) of approximately 150 days of age were withdrawn from a freely-growing, confined laboratory population. When compared with bisexually paired controls, the population mice exhibited significantly lighter body weights and testis weights. Light and electron microscopic examination of seminiferous tubules from these population animals revealed a variable level of spermatogenlc impairment ranging from severe regression to apparently normal sper­ matogenesis. Previous research suggests that elevated adrenocortical production of sex steroids due to stress may cause feedback inhibition of hypophysial production of FSH and LH, resulting in regression of the seminiferous tubules• The conclusions allowed by this study are* 1) Spermatogenic impairment is typical of deer mice from a freelygrowing, confined population, but is not typical of bisex­ ually paired controls. 2) The extent of this spermato­ genlc impairment is variable.
Adapting to climate change in small-scale fisheries: Insights from Indigenous communities in the 1 global north and south 2

9 Climate change is having a significant influence on global fish production as well as on small- 10 scale fishers’ livelihoods, nutrition, and food security. We compared two climate-sensitive small- 11 scale fisheries (SSFs) – an Inuit community in the Canadian Arctic and the Coastal-Vedda in Sri 12 Lanka – to broaden our understanding of how fisheries-dependent Indigenous communities 13 respond and adapt to climate change impacts. We used three steps to achieve this comparative 14 study. To do this, we developed a resilience-based conceptual framework to empirically assess 15 adaptations in two SSF communities, based on a literature review. Using the proposed framework 16 and collecting qualitative field data over three years (2016-2019) to investigate how different 17 remote SSFs experience and respond to climate change, we assessed Inuit and Coastal-Vedda case 18 studies. The framework provided the structure for data analysis and conceptual guidance for two 19 empirical assessments and the comparative analysis. Finally, we carried out the comparative 20 analysis across the case studies using content analysis, identifying adaptive strategies, sources of 21 resilience, and characteristics of successful adaptation. Additionally, we used discourse analysis 22 to develop sources of resilience and characteristics of successful adaptation. Two key adaptive 23 strategies emerged in common across the two communities – diversification and adaptive co- 24 management. Eight sources of resilience that underpin adaptive capacity: i) use of diverse kinds 25 of knowledge; ii) practice of different ways of learning; iii) use of community-based institutions; 26 iv) efforts to improve human agency; v) unique worldviews; vi) specific cultural attributes that 27 keep up with adaptation; vii) effective social networks; and viii) a high Definitive characteristics need knowledge co-production; capacity-building to improve human agency; a place- specific nature community-based