Miracle-dz/UniFAR-FTUs huggingface dataset:
ENSO events and consequences on nutrient, planktonic biomass, and production in the western tropical pacific ocean

ENSO events change the hydrographical structures and the planktonic biomass and production particularly in the low latitude region of the Pacific Ocean. We compare here the consequences of these variations at 165°E, in two opposite situations, i.e. during an ENSO event in September 1987 and during an non ENSO event in September 1988. Preliminary conclusions show: (i) for the nutrients in September 1987, a thick nutrient-depleted mixed layer (under detectable limits) along the transect, except at 10"S and 9"S and in September 1988, a wide upweiling between 5*S and 2'N with surface nitrate concentrations ranging between 0.3 and 2 |1M; (ii) for phytoplankton, the abundance of cyanobacteria (procaryotes) and microalgae (eucaryotes) shows large changes both in cells abundance and depth distribution between the two periods. Overall, there is a close relationship between upweiling and increase of phytoplankton abundance and chlorophyll biomass. The integrated values over 0-120m are higher in September 1988 than in September 1987: 5 times for cyanobacteria cells, 3 times for microalgae and 1.4 times for chlorophyll between 6-5 "S and 2*N; (iii) primary production maximum is deeper during ENSO event whereas it is shallow in the upweiling situation. The level of production increased during the upweiling: the integrated value in the 0-120 m averaged (n=7), about 150 versus 59 mgCm^h; (iv) for zooplankton (200-2000 |lm), there is a significant increase due to the equatorial upweiling in non-ENSO period and none in ENSO event, although a biomass peak appears around 10"S together with die nutrient enrichment
Granodiorita El Sótano: plutón jurásico deformado aflorante en el basamento de Las Grutas, Macizo Norpatagónico Atlántico

El Sotano Granodiorite: a deformed Jurassic pluton in the basement of Las Grutas, Atlantic Northpatagonian Massif. Igneous and metamorphic rocks belonging to a crystalline basement crop out to the south of Las Grutas beach, Rio Negro Province. Within these rocks, a small granodioritic exposure was identified and named El Sotano Granodiorite. The granodiorite shows a magmatic foliation developed by NW-trending feldspar phenocrysts, and an overprinting brittle to ductile deformation at low metamorphic grade coeval with a hydrothermal activity. The conventional U-Pb zircon age of 186 ± 9 Ma is interpreted as crystallization at an early magmatic stage, whereas the Rb-Sr whole rock and mineral isochron of 174 ± 22 Ma might indicate the timing when the cooling system passed around 300°C and the deformation fabric was almost completed. The crystallization age and the location of the granodiorite are consistent with the initial stages of the extensive Jurassic volcanism developed throughout Patagonia. The Nd and Sr isotopic characterization (eNd -5.7, and initial 87 Sr/ 86 Sr 0.7071) as well as the granodioritic composition are all comparable with those of the initial andesitic to dacitic layers of the volcanism. However, the volcanic rocks do not show a pervasive brittle-ductile deformation, and therefore, the deformation found in the El Sotano Granodiorite must be the result of a local stress field, despite the NW orientation of the folitation that is also shared by both the compressive Permian structures and the extensional Triassic to Jurassic structures of the region.
A validation of eye movements as a measure of elementary school children ’ s developing number sense

The number line estimation task captures central aspects of children’s developing number sense, that is, their intuitions for numbers and their interrelations. Previous research used children’s answer patterns and verbal reports as evidence of how they solve this task. In the present study we investigated to what extent eye movements recorded during task solution reflect children’s use of the number line. By means of a cross-sectional design with 66 children from Grades 1, 2, and 3, we show that eye-tracking data (a) reflect grade-related increase in estimation competence, (b) are correlated with the accuracy of manual answers, (c) relate, in Grade 2, to children’s addition competence, (d) are systematically distributed over the number line, and (e) replicate previous findings concerning children’s use of counting strategies and orientationpoint strategies. These findings demonstrate the validity and utility of eye-tracking data for investigating children’s developing number sense and estimation competence. © 2008 Elsevier Inc. All rights reserved. Number sense is the “ability to quickly understand, approximate, and manipulate numerical quantities” (Dehaene, 2001, p. 16). The “mental number line” is regarded as the core neurocognitive system underlying number sense (Fias, Lammertyn, Reynvoet, Dupont, & Orban, 2003; Hubbard, Piazza, Pinel, & Dehaene, 2005; Pinel, Dehaene, Riviere, & LeBihan, 2001), which in turn underlies a variety of ∗ Corresponding author at: Institute for Behavioral Sciences, ETH Zürich, CAB G84.2, Universitaetsstrasse 6, 8092 Zürich,
Plan S: What You Need to Know

needs met. The demands placed on patients are best described in the following passage: “Modern health systems make complex demands on the health consumer. As self-management of healthcare increases, individuals are asked to assume new roles in seeking information, understanding rights and responsibilities, and making healthcare decisions for themselves and others” (NielsenBohlman et al., 2004). Obviously, the healthcare system places multiple demands on the individual. Meeting these demands assumes that the individual or consumer has the skills necessary to interact with the healthcare system and understand his healthcare needs. However, national and international literacy survey results show that at least half of the population may not have theses skills (Nielsen-Bohlman et al., 2004). This discrepancy has caused great concern in the medical community, because advances in health science could be negated by patients who do not have the skills to use or understand these scientific achievements. The concept of health literacy has come to the forefront in healthcare. Health literacy is defined as: “The degree to which individuals have the capacity to obtain, process, and understand basic health information and services needed to make appropriate health decisions” (Ratzen & Park, 2000). Half of our population has limited literacy skills, which affects health literacy. To determine the extent of this impact, the Institute of Medicine formed a committee to examine health literacy. This committee’s findings and recommendations form the foundation for this article (Nielsen-Bohlman, Panzer, & Kindig, 2004). As nurses we need to use this knowledge about health literacy to assist our patients in understanding their health and interacting with the healthcare system.
Mesenchymal Stem Cell-Derived Extracellular Vesicles in Cancer Therapy Resistance: from Biology to Clinical Opportunity

Mesenchymal stem cells (MSCs) are a type of stromal cells characterized by their properties of self-renewal and multi-lineage differentiation, which make them prominent in regenerative medicine. MSCs have shown significant potential for the treatment of various diseases, primarily through the paracrine effects mediated by soluble factors, specifically extracellular vesicles (EVs). MSC-EVs play a crucial role in intercellular communication by transferring various bioactive substances, including proteins, RNA, DNA, and lipids, highlighting the contribution of MSC-EVs in regulating cancer development and progression. Remarkably, increasing evidence indicates the association between MSC-EVs and resistance to various types of cancer treatments, including radiotherapy, chemotherapy, targeted therapy, immunotherapy, and endocrinotherapy. In this review, we provide an overview of the recent advancements in the biogenesis, isolation, and characterization of MSC-EVs, with an emphasis on their functions in cancer therapy resistance. The clinical applications and future prospects of MSC-EVs for mitigating cancer therapy resistance and enhancing drug delivery are also discussed. Elucidating the role and mechanism of MSC-EVs in the development of treatment resistance in cancer, as well as evaluating the clinical significance of MSC-EVs, is crucial for advancing our understanding of tumor biology. Meanwhile, inform the development of effective treatment strategies for cancer patients in the future.
Classification of First-Episode Psychosis with EEG Signals: ciSSA and Machine Learning Approach

First-episode psychosis (FEP) typically marks the onset of severe psychiatric disorders and represents a critical period in the field of mental health. The early diagnosis of this condition is essential for timely intervention and improved clinical outcomes. In this study, the classification of FEP was investigated using the analysis of electroencephalography (EEG) signals and circulant spectrum analysis (ciSSA) sub-band signals. FEP poses a significant diagnostic challenge in the realm of mental health, and it is aimed at introducing a novel and effective approach for early diagnosis. To achieve this, the LASSO method was utilized to select the most significant features derived from entropy, frequency, and statistical-based characteristics obtained from ciSSA sub-band signals, as well as their hybrid combinations. Subsequently, a high-performance classification model has been developed using machine learning techniques, including ensemble, support vector machine (SVM), and artificial neural network (ANN) methods. The results of this study demonstrated that the hybrid features extracted from EEG signals’ ciSSA sub-bands, in combination with the SVM method, achieved a high level of performance, with an area under curve (AUC) of 0.9893, an accuracy of 96.23%, a sensitivity of 0.966, a specificity of 0.956, a precision of 0.9667, and an F1 score of 0.9666. This has revealed the effectiveness of the ciSSA-based method for classifying FEP from EEG signals.
Estimation of Equipment Remaining Useful Life based on WTEE- RNN Method

Nuclear power plants have a large number of safety or non-safety related mechanical equipment. Knowing when and where these equipment failure or near failure is one of the key problems in nuclear safety and nuclear health management and maintenance, that is to predict the remaining useful life for specific equipment. A prediction model labeled as Weibull time to event recurrent neural network (WTTE-RNN) is proposed to effectively obtain the prediction and estimation of time to event (such as customer churn, patient survival, machine failure). The model is effective even under some missing-spots in the training data (i.e. deleted data). The purpose of this research is to study the main challenges faced by the application of WTTE-RNN to the nuclear equipment, and identify feasible optimization directions. The results may lay a foundation for the WTTE-RNN application to the remaining useful life.
UvA-DARE (Digital Academic Repository) Cancer patients’ needs for support in expressing instrumental concerns and emotions

Introduction: The aim of our study was to provide an overview of intervention guide‐ lines on how to address patients' practical needs for support in expressing instru‐ mental concerns and emotions regarding medical, psychosocial and practical topics. Methods: Six focus groups of cancer patients and survivors ( N = 39) were organised. An interview guide was created that consisted of three topics: (a) concerns, (b) needs for support, and (c) a Concern Prompt List. Using the framework method, the tran‐ scripts were coded and analysed in Atlas T.I. Results: Patients prefer to receive practical and emotional support, help with prep‐ aration, prompts/cues, instructions on how to perform the behaviour (i.e., express their concerns or emotions), feedback, a different structure for the consultation and tailoring. Most of these techniques should preferably be delivered via interpersonal communication. Needs sometimes differ for instrumental concerns and emotions. Only some needs for support were exclusively related to instrumental concerns or emotions. The typical needs for support were not solely linked to the medical, psy‐ chosocial and practical topics. Conclusion: Different needs to express instrumental concerns and emotions through‐ out the disease trajectory are categorised. These needs provide input for developing interventions to support concern expression.
Forthcoming

Purpose – The purpose of this paper is to critically examine the multinational oil companies’ (MOCs) corporate social responsibility (CSR) initiatives in Nigeria. Its special focus is to investigate the impact of the global memorandum of understanding (GMoU) on women involved in offshore and inshore fisheries entrepreneurship in the coastal communities of the Niger Delta region. Design/methodology/approach – This paper adopts a survey research technique, aimed at gathering information from a representative sample of the population, as it is essentially cross-sectional, describing and interpreting the current situation. A total 800 respondents were sampled across the coastal communities of the Niger Delta region. Findings – The results from the use of a combined propensity score matching (PSM) and logit model indicate that the GMoU model is gender insensitive as extensive inequality restrains fisherwomen’s participation in the offshore and inshore fisheries entrepreneurship, often due to societal norms and customs that greatly frustrate women’s development in fisheries. Practical implication – This implies that if fisherwomen continue in this unfavourable position, their reliance on menfolk would remain while trying to access financial support and decision making regarding fisheries entrepreneurship development. Social implications – The inshore and offshore fisheries entrepreneurship development can only succeed if cluster development boards (CDBs) of GMoUs are able to draw all the resources and talents and if fisherwomen are able to participate fully in the GMoUs intervention plans and programme. Originality/value – This research contributes to the gender debate in fisheries entrepreneurship development from a CSR perspective in developing countries and rationale for demands for social projects by host communities. It concludes that business has an obligation to help in solving problems of public concern, and that CSR priorities in subSaharan Africa should be aimed toward addressing the peculiarity of the socio-economic development challenges of the countries and be informed by socio-cultural influences.
Genética y estructura de la población vizcaína. Genetics and Structure of the Basque Population.

La población Vasca, una de las más antiguas de Europa, presenta actualmente una amplia mezcla genética. Sin embargo, es todavía posible estudiar individuos autóctonos, identificables porque sus apellidos son vascos. Un grupo de 196 individuos con estas características fue clasificado como Vizcaínos, ya que sus cuatro abuelos habían nacido en la provincia de Vizcaya. El estudio de 4 polimorfismos proteícos y 14 enzímas ha puesto de manifiesto claras diferencias genéticas entre la población Vizcaína y otras poblaciones españolas y europeas en algunos marcadores, mientras que otros marcadores han demostrado tener la misma distribución de frecuencias génicas que la observada por otros investigadores. La panorámica conjunta de la similitud o diferencia genética de esta población Vizcaína con respecto a otras poblaciones se ha calculado mediante las distancias genéticas de Nei y el análisis de cluster basado en la matriz de estas distancias. Dada la compleja orografía del País Vasco, y el aislamiento, actualmente casi inexistente, de los habitantes de algunos de sus valles, es conveniente efectuar un estudio más detallado de la estructura genética de la población Vizcaína. Con este objetivo se tomaron nuevas muestras de individuos autóctonos procedentes de regiones concretas: Arratia, Gernika, Uribe, Markina costa, Markina interior y Durango. La variación genética fue estimada de manera sencilla, midiendo la heterocigosidad. También se han calculado los coeficientes FIS, FIT y FST para estimar la diferenciación genética entre las regiones estudiadas. Con el objeto de incluir en el estudio todos los sistemas proteícos y enzimáticos analizados, incluso los que cuentan con tres o mas alelos, se han calculado otros parámetros de estima de la diferenciación genética entre subpoblaciones DSTB ó diferenciación de cada subpoblación con respecto a la población total GST. La matriz de distancias genéticas entre las subpoblaciones Vizcaínas se calculó según Nei y el dendrograma fue obtenido aplicando el programa Biosys-1. De todos los resultados puede inferirse heterogeneidad en la población autóctona Vizcaína probablemente debida al aislamiento entre algunos de los grupos que la componen.
Surface Water and Groundwater Hydraulics, Exchange, and Transport During Simulated Overbank Floods Along a Third-Order Stream in Southwest Virginia

Restoring hydrologic connectivity between the channel and floodplain is a common practice in stream and river restoration. Floodplain hydrology and hydrogeology impact biogeochemical processing and potential nutrient removal, yet rigorous field evaluations of surface and groundwater flows during overbank floods are rare. We conducted five sets of experimental floods to mimic floodplain reconnection. Experimental floods entailed pumping stream water onto an existing floodplain swale, and were conducted throughout the year to capture seasonal variation. Each set of experimental floods entailed two replicate floods occurring on successive days to test the effect of varying antecedent moisture. Water levels and specific conductivity were measured in surface water, shallow soils, and deep soils, along with surface flow into and out of the floodplain. Total flood water storage increased as vegetation density increased and or antecedent moisture decreased. Hydrologic flow mechanisms were spatially and temporally heterogeneous in surface water, in groundwater, as well as in exchange between the two and appeared to coexist in small areas. Immediate propagation of hydrostatic pressure into deep soils was suggested at some locations. Preferential groundwater flow was suggested in locations where the pressure and electrical conductivity signals propagated too fast for bulk Darcy flow through porous media. Preferential flow was particularly obvious where the pressure signal bypassed an intermediate depth but was observed at a deeper depth. Bulk Darcy flow in combination with preferential flow was suggested at locations where the flood pressure and electrical conductivity signal propagated more slowly yet arrived too quickly to be described using Darcy’s Law. Finally, other areas exhibited no transmission of pressure or conductivity signals, indicating a complete lack of groundwater flow. Antecedent moisture affected the flood pulse arrival time and in some cases vertical connectivity with deeper sediments while vegetation density altered surface water storage volume. Understanding the variety of exchange mechanisms and their spatial variability will help understand the observed variability of floodplain impacts on water quality, and ultimately improve the effectiveness of floodplain restoration in reducing excess nutrient in river basins.
Highlight and Breakthrough. A fresh look at crystals in the Bishop Tuff

Abstract Crystals constitute potential sources of information on magmatic timescales, conditions, and processes. One could say that the ecology of crystals in magmas is very rich, including phenocrysts, microlites, xenocrysts, and antecrysts, to name just a few types. A recent reassessment of thermodynamic equilibrium between crystals in the Bishop Tuff has concluded to the reliability of temperature estimates based on Fe-Ti oxides.
Biological and clinical significance of the glypican-3 gene in human lung adenocarcinoma: An in silico analysis

Glypican-3 (GPC3), a membrane-bound heparan sulfate proteoglycan, has long been found to be dysregulated in human lung adenocarcinomas (LUADs). Nevertheless, the function, mutational profile, epigenetic regulation, co-expression profile, and clinicopathological significance of the GPC3 gene in LUAD progression are not well understood. In this study, we analyzed cancer microarray datasets from publicly available databases using bioinformatics tools to elucidate the above parameters. We observed significant downregulation of GPC3 in LUAD tissues compared to their normal counterparts, and this downregulation was associated with shorter overall survival (OS) and relapse-free survival (RFS). Nevertheless, no significant differences in the methylation pattern of GPC3 were observed between LUAD and normal tissues, although lower promoter methylation was observed in male patients. GPC3 expression was also found to correlate significantly with infiltration of B cells, CD8+, CD4+, macrophages, neutrophils, and dendritic cells in LUAD. In addition, a total of 11 missense mutations were identified in LUAD patients, and ~1.4% to 2.2% of LUAD patients had copy number amplifications in GPC3. Seventeen genes, mainly involved in dopamine receptor-mediated signaling pathways, were frequently co-expressed with GPC3. We also found 11 TFs and 7 miRNAs interacting with GPC3 and contributing to disease progression. Finally, we identified 3 potential inhibitors of GPC3 in human LUAD, namely heparitin, gemcitabine and arbutin. In conclusion, GPC3 may play an important role in the development of LUAD and could serve as a promising biomarker in LUAD.