Miracle-dz/UniFAR-FTUs huggingface dataset:
The Radiological Anatomy of the Distal Tibiofibular Joint: A Retrospective Computed Tomography Study

Introduction Distal tibiofibular joint (DTFJ) injuries are commonly encountered in patients with ankle fractures. Achieving optimal fixation is mandatory, but it requires a thorough understanding of the local anatomical relationships. For this reason, we performed a retrospective CT study in healthy ankles to radiologically describe the normal anatomy of the DTFJ and the anatomical relationship of the fibula within the ankle joint. Materials and methods For this study, we retrospectively examined 60 CT scans of healthy, non-injured ankles in a plantigrade position. Patients with prior ankle surgery or systemic diseases with ankle involvement were excluded because we needed to describe the normal anatomy of the joint. The radiological evaluation included the position of the fibula in the fibular notch and the rotational relationship of the fibula with the talus and the medial malleolus. Results Our study included 60 healthy ankles. Thirty-three were right ankles, and 27 were left. The cohort included 36 females and 24 males with a mean age of 48.3 years old. We found that the fibular notch was retroverted on the transverse plane, with the tibiofibular engagement being 0.11 mm (SD=1.57 mm, SE=0.2 mm), at 1 cm proximally to the tibial plafond. Additionally, we observed that the fibula was internally rotated against the lateral talar facet, while the medial and lateral malleolus facets were externally rotated in between. Moreover, we found a strong positive correlation between the incisura retroversion and fibular engagement at 1 cm above the tibial plafond line (Pearson correlation=0.273, p=0.03). Conclusion Our study highlights the importance of gaining a comprehensive understanding of the inherent anatomy of the DTFJ to achieve reduction goals in ankle fractures. According to our results, in ankle fracture treatment, surgeons should aim for anatomical fracture and syndesmotic fixation, with the fibula in internal rotation against the lateral talar facet. Additionally, as normal tibiofibular engagement is borderline, we do not suggest that over-tightening the syndesmotic screws is essential. This study's findings can aid surgeons in reducing the malreduction rates in patients with ankle fractures.
Counting and classifying mosquitoes from a distance with ultra cheap sensors

In the last century entomologists have developed an arsenal of mechanical, chemical, biological and educational tools to help mitigate the harmful effects of mosquitoes. Since all such interventions are costly, they depend on knowing the best time and place to intervene. As a group of medical entomologists recently noted: “Accurately georeferenced collection data are crucial for understanding mosquito biogeography, ecology, and the impact of environmental changes, as well as for species distribution modeling, planning mosquito surveys, and for determining disease risk” (Foley et. al 2009). Such data is currently obtained by having humans inspect mechanical or “sticky” traps (Bhalala and Arias 2009). As such, the data is typically sparse, error-prone and out of date.
Starch Polysaccharides in the Human Diet: Effect of the Different Source and Processing on its Absorption

Starch is the main source of carbohydrates in human diet. It is widely used in food processing and non-food industrial applications. The effects on starch digestion and absorption in humans are reviewed in relation to the starch composition, sources, plant genetic variation, food processing and cooking. The impact of food industrial processing and starch modification on the digestibility of starch containing foods and on gut microbiota are discussed. Considering that the resistant starch (RS) fraction escaped from the small intestine is fermented in large intestine, all the variables that influence starch digestibility and absorption must be taken into account when discussing about healthy properties of fibers. Future trends in food industries are aimed to increase the RS fraction in processed foods in order to improve nutritional quality as well as to clarify the influence of RS3 and RS4 on gut microbiota.
The Impact of Genetics on Cognition: Insights into Cognitive Disorders and Single Nucleotide Polymorphisms

This article explores the complex relationship between genetics and cognition, specifically examining the impact of genetic variants, particularly single nucleotide polymorphisms (SNPs), on cognitive functions and the development of neuropsychiatric disorders. Focusing on neurotransmitter regulation within the prefrontal cortex’s dopaminergic circuits, this study emphasizes the role of genes like COMT, PRODH, and DRD in shaping executive functions and influencing conditions such as ADHD and schizophrenia. Additionally, it explores the significance of genetic factors in neurodevelopmental disorders, emphasizing the need for early identification to guide appropriate therapeutic interventions. This article also investigates polymorphisms in the transsulfuration pathway, revealing their association with cognitive impairment diseases. Computational analyses, including machine learning algorithms, are highlighted for their potential in predicting symptom severity in ADHD based on genetic variations. In conclusion, this article underscores the intricate interplay of genetic and environmental factors in shaping cognitive outcomes, providing valuable insights for tailored treatments and a more comprehensive understanding of neuropsychiatric conditions.
A Regional Perspective of Shallow-Burial Diagenesis of Deep-Water Periplatform Carbonates from the Northern Bahamas

Detailed studies of carbonate mineralogy and geochemistry using samples recovered by deep-sea drilling in the northern Bahamas document shallow-burial (<250 mbsf) diagenetic trends that occur in two stages. Stage 1 diagenesis (0-10 meters below the seafloor, mbsf) results in rapid, extensive calcitization and local dolomitization in marine-derived pore fluids. Stable oxygen isotopes are quickly enriched, while carbon values are depleted. Aragonite undergoes dissolution and high-magnesian calcite exsolves to low-magnesian calcite. Below 10 to at least 185 mbsf, stage 2 diagenesis continues to alter primary components, leading to ooze-chalk and chalk-limestone transformations and low amounts of dolomite, while rates and amplitudes of change are considerably less than in stage 1. Oxygenand carbon-isotope ratios indicate that diagenesis still occurs in marine-derived pore fluids. Overall, shallow-burial diagenesis of periplatform carbonates proceeds much more readily than diagenesis of deepsea pelagic ooze. This is because of higher diagenetic potential related to the influx of metastable shallow-water-derived components in a deep-marine realm. Subsurface calcitization and lithification of periplatform sediments occurs rapidly with depth in regions of moderate accumulation rates (20-60 m/m.y.; north of Little Bahama Bank). This is a result of an interpreted greater rate of diagenetic alteration with burial, and in deep (3000 m) water is related to seawater saturation levels relative to carbonate mineralogy. Calcitization and local dolomitization may occur at or near the sediment/ water interface during formation of disconformities. In contrast, metastable aragonite and high-magnesian calcite are present in significant amounts at depth in regions with high accumulation rates (>90 m/m.y., Exuma Sound), despite lithification that produces chalk and limestone. The presence of metastable components in porous limestones in Exuma Sound underscores the current high diagenetic potential for these rocks and the development of reservoir potential in periplatform deep-water limestones at shallow sub-bottom depths. DEDICATION This paper is dedicated to the memory of H. Mark Van Buren, who, at the age of 36, died because of medical complications from an automobile accident on January 16, 1986 in San Jose, California. Mark's 1984 Master's thesis—"Seismic Stratigraphy of a Modern Carbonate Slope: Northern Little Bahama Bank"—was the basis for many of the objectives of Leg 101, Sites 627 through 630. Mark's work focused on the now widely cited bathymetry of the deep bank margin north of Little Bahama Bank, as well as on 3.5-kHz echo-character studies and seismic sequence analysis. Mark also discovered Walkers Cay Fault, a prominent northeast-southwest striking fault zone normally oriented to the bank margin of Little Bahama Bank. All these studies influenced both the design and execution of Leg 101 drilling north of Little Bahama Bank.
An exploration of new avenues regarding deep tissue penetration and highersinglet oxygen efficiencies: novel near-IR photosensitizers for photodynamictherapy

A series of novel BODIPY-bearing electron-withdrawing groups at the meso position are reported here. According to the optical measurements, it may be clearly seen that the introduction of electron-donating groups into 3,5-positions and the presence of electron-withdrawing groups at the meso position of the BODIPY core resulted in spectacular bathochromic shifts (up to ∼ 304 nm), and the projected photosensitizers had absorption bands in the therapeutic window of the electromagnetic spectrum (600-900 nm). The absorption maxima of compounds 4,5,6, and 7 were at 886 nm, 890 nm, 760 nm, and 761 nm, respectively. The singlet oxygen generation experiments revealed that compounds 6 and 7, with high singlet oxygen quantum yields (0.52 and 0.93, respectively), were excellent and promising candidates for photodynamic therapy. The singlet oxygen quantum yield of 0.93 was the highest reported value so far for BODIPY-based photosensitizers.
Geochemical characterization of the ground waters from the former Hg-mining area of Abbadia San Salvatore (Mt. Amiata, central Italy): criticalities and perspectives for the reclamation process

This study was aimed to geochemically characterize the groundwater system of the Abbadia San Salvatore (Mt. Amiata, Siena, central Italy) former Hg-mining area, whose activity closed at the end of the seventies, in order to accomplish the reclamation process after that the former ownership of the mining concession (E.N.I. National Agency for Hydrocarbons, AGIP Division) passed the property to the Munici pality of Abbadia San Salvatore in 2008. The study area covers a surface of about 65 ha and since February 2013 old and new piezometers were used to assess the main chemical features along with the concentrations of As, Hg and Sb. Four sampling campaigns were carried out up to January 2014 and a relatively large spatial and temporal geochemical variability was observed. Apparently, the working activities related to the construction of an artificial channel (commenced in March 2013 and terminated at the end of 2013), which crosscuts the whole mining area to drain the surface waters in order to minimize the interaction between the meteoric waters and the by-products deriving by the production of metallic mercury, did not affect the groundwater system. Slag, roasted material and other by-products deriving from the local and surrounding Hg mining activities were indeed used to fill the terrain where most of the mining structures lie. The dominating geochemical facies was Ca(Mg)-SO4 and, subordinately, Ca(Mg)-HCO3, while Na-HCO3 compositions were rarely found. Dissolution of gypsum/anhydrite and carbonates and hydrolysis of sulfide minerals are likely the main geochemical process that produced the observed geochemical compositions. The contents of As and Sb only sporadically exceeded the maximum allowable concentrations intended for human consumption (98/83 EC Directive 1998), i.e. 10 and 5 mg L-1. Conversely, those of Hg were constantly above the EC directive, e.g. 1 mg L-1, with the exception of those waters located up- and downstream the groundwater flow. This indicates that the exotic filling terrains in the mining area, mainly consisting of roasting products, likely play a pivotal role in regulating the concentrations of Hg, which reached values up 853 mg L-1. The construction of permeable reactive barriers, located downstream the water flow, appears to be the most promising solution for the removal of Hg, although, according to the literature, several materials, tested with laboratory experiments, can be used and, as a consequence, it is necessary to individuate specific piezometers with different Hg concentrations where pilot investigations are to be carried out before undertaking any remediation actions.
New Modalities in Knee Osteoarthritis Treatment Using Autologous Bone Marrow-Derived Mononuclear Cells

Abstract The clinical effects on knee osteoarthritis (OA) symptoms and tissue structure were evaluated after bone marrow-derived mononuclear cell intraarticular injection. A group of 32 patients with 34 knee joints in stage II–III osteoarthritis were treated by intraarticular injection of mononuclear cell suspension. Clinical results were obtained by KOOS (Knee Osteoarthritis Outcome Score) and KSS (Knee Society Score) scores during a 12 months follow-up period. Radiological evaluation was performed using magnetic resonance imaging. A comparison with a control group of 28 patients treated with routinely used three hyaluronic acid intra-articular injections was made. No adverse effects were observed after the bone marrow derived mononuclear cells (BM-MNC) injection. At the end point of the follow up all score results had improved, compared to those at to the starting point. 65% of patients maintained minimal perceptible clinical improvement of the score results. The Whole Organ Magnetic Resonance Imaging Score showed improvement from 44.31 to 42.93 points (p < 0.05) during a 6–7 month period. Comparing score results to the control group, a statistically significant (p < 0.05) improvement in the KOOS pain subscale score at the 6 and 12 months was observed in the mononuclear cell group. BM-MNC injection leads to a decrease of knee OA symptoms and slows changes in structure of the degenerative joint tissue.
Upper-bound solutions for face stability of circular tunnels in undrained clays

The aim of this paper is to determine the critical supporting pressure on the circular face of an advancing tunnel in undrained clay in which undrained strength increases linearly with depth. Based on the kinematic approach of limit analysis, a continuous velocity field with a toric envelope is adopted to yield upper bounds of the face pressure for both collapse and blow-out. Combining with a closed-form expression describing the overall velocity field, an optimisation procedure is carried out to find the lowest upper-bound solutions. The calculated results are presented in terms of a dimensionless coefficient N (called the stability number) and then stability charts for use are produced. Alternatively, an approximation formula is given to estimate easily the collapse and blow-out pressure in practice.
The Mechanism of Tigecycline Resistance in Acinetobacter baumannii under Sub-Minimal Inhibitory Concentrations of Tigecycline

The presence of sub-minimal inhibitory concentration (sub-MIC) antibiotics in our environment is widespread, and their ability to induce antibiotic resistance is inevitable. Acinetobacter baumannii, a pathogen known for its strong ability to acquire antibiotic resistance, has recently shown clinical resistance to the last-line antibiotic tigecycline. To unravel the complex mechanism of A. baumannii drug resistance, we subjected tigecycline-susceptible, -intermediate, and -mildly-resistant strains to successive increases in sub-MIC tigecycline and ultimately obtained tigecycline-resistant strains. The proteome of both key intermediate and final strains during the selection process was analyzed using nanoLC-MS/MS. Among the more than 2600 proteins detected in all strains, we found that RND efflux pump AdeABC was associated with the adaptability of A. baumannii to tigecycline under sub-MIC pressure. qRT-PCR analysis also revealed higher expression of AdeAB in strains that can quickly acquire tigecycline resistance compared with strains that displayed lower adaptability. To validate our findings, we added an efflux pump inhibitor, carbonyl cyanide m-chlorophenyl hydrazine (CCCP), to the medium and observed its ability to inhibit tigecycline resistance in A. baumannii strains with quick adaptability. This study contributes to a better understanding of the mechanisms underlying tigecycline resistance in A. baumannii under sub-MIC pressure.
INVESTOR SENTIMENTS: A DEEP DIVE INTO THE COLLECTIVE MOOD OF THE MARKET

Investor sentiment, the collective mood and perception of market participants, is a dynamic force that significantly influences financial markets. Investor sentiment is a critical driver of financial markets, reflecting the collective perceptions, attitudes and emotions of market participants. This study explores the multifaceted nature of investor sentiments. This study investigates the primary factors that contribute to shifts in investor sentiment, including economic indicators, corporate performance, geopolitical events, and broader macroeconomic trends. It analyzes how information asymmetry, behavioral biases, and social influences collectively contribute to the formation of investor sentiment. This study aims to provide a comprehensive understanding of how investor psychology influences the financial markets. Understanding investor sentiment is crucial for market participants, policymakers, and researchers seeking to comprehend market movements and develop effective risk management strategies. The study provides insights into the complex interplay of psychological, economic, and technological factors that underpin investor sentiment, contributing to a comprehensive understanding of contemporary financial markets.
Modelos central y atribucional de la percepción estudiantil de la enseñanza y de su aprendizaje

Introducción: Se presenta el modelo central de la percepción del estudiante que ofrece una caracterización general de su percepción y del papel de esta en la relación entre la enseñanza, el aprendizaje y el contexto, desde una perspectiva socio-cognitiva. También, se presenta el modelo atribucional de la percepción del estudiante, que se basa en el modelo central e integra la mirada de la teoría atribucional de Weiner. Antecedentes: El aporte teórico realizado se basa en el análisis de la percepción del estudiante desde la mirada de la psicología social cognitiva y teorías socio-cognitivas de la motivación, y un enfoque substantivo a la validez de constructo. Discusión: Los modelos presentados ofrecen un marco conceptual útil para la investigación de la calidad de la enseñanza y el aprendizaje, el desarrollo y validación de instrumentos y en evaluación educativa.
Maternity colony of Northern Long-eared Myotis ( Myotis septentrionalis ) in a human-made structure in Nebraska

The Northern Long-eared Myotis (Myotis septentrionalis) occurs across eastern North America, and its range extends west into the Great Plains of the United States. Summer roosts of M. septentrionalis in the Great Plains are not well documented. Herein we describe a maternity colony of M. septentrionalis using small, elevated structures (i.e., cabins) in southeastern Nebraska. Cabins were in a small parcel of upland deciduous forest about 1.6 km from the Missouri River. The maternity colony was observed roosting in a space between the outer and inner walls of three different cabins from 21 June to 8 October 2014. Counts of individuals using the cabins suggest that the colony started to disband after mid-August. Identifying and monitoring maternity roosts of M. septentrionalis in the Great Plains will be important to effectively manage this federally threatened species, especially as the fungus that causes white-nose syndrome spreads into the region.
Differences in Pubertal Curve Progression among Females with Adolescent Idiopathic Scoliosis Using Pregnenolone Therapy: A Retrospective Case-Controlled Series

Background: Differences in hormone metabolism have been observed in children with adolescent idiopathic scoliosis. These differences have been offered as underlying reasons for rapid curve progression during puberty. This study retrospectively compared two groups of females with a history of adolescent idiopathic scoliosis. They were seen for initial presentation prior to menarche, or within 2 months after menarche, and they were followed up 1 year after first menarche. Methods: All patients in both groups underwent baseline salivary hormone testing to identify any hormone imbalances. The control group was composed of females with curves between 10 and 25 degrees and maintained an observation-only management strategy. The treatment group showed baseline curve measurements ranging from 10 to 23 degrees, and additionally took pregnenolone daily for 12 months. Results: At one-year follow-up, the treatment group showed curve measurements ranging from 13 to 24 degrees, while the control group ranged from 16 to 29 degrees (p < 0.05). Conclusions: The study showed that adolescent females taking pregnenolone daily for low progesterone had reduced scoliosis curve progression over 1 year compared to controls.
Biodegradation potentials of edaphic bacterial isolates cultured on Haloxyfop R Methyl ester herbicide-mineral salt medium

The heterotrophic and haloxyfop-R methyl ester utilizing bacterial counts associated with top soil samples was evaluated. Three (3) bacterial isolates; Bacillus sp. , Micrococcus sp. and Staphylococcus sp. were cultured and screened for their ability to utilize haloxyfop-R methyl ester as sole source of carbon and energy using the turbidimeteric procedure. The growth profiles of two axenic cultures; Bacillus sp. and Micrococcus sp. were determined using the shake flask test. Parameters which included pH, mean viable bacterial counts, optical density and dissolved CO2 were determined during growth profiling using relevant procedures and equipment. The pH of the soil samples was 5.08 ± 0.02 for sample A and 4.62 ± 0.02 for sample B. The total heterotrophic bacterial count was 2.8 × 104 cfu/g ± 849 for A and 4.62 × 104 cfu/g ± 989 for B. The mean dissolved CO2 data for Micrococcus sp. during the growth profile study ranged from 1.1 mg/l ± 0.1 to 6.8 mg/l ± 0.2. Axenic Micrococcus sp. was the most effective amongst the growth profile cultures in mineralizing the herbicide content of the culture medium.
The Impact of LY487379 or CDPPB on eNOS Expression in the Mouse Brain and the Effect of Joint Administration of Compounds with NO• Releasers on MK-801- or Scopolamine-Driven Cognitive Dysfunction in Mice

The role of endothelial nitric oxide synthase (eNOS) in the regulation of a variety of biological processes is well established, and its dysfunction contributes to brain pathologies, including schizophrenia or Alzheimer’s disease (AD). Positive allosteric modulators (PAMs) of metabotropic glutamate (mGlu) receptors were shown to be effective procognitive compounds, but little is known about their impact on eNOS expression and stability. Here, we investigated the influence of the acute and chronic administration of LY487379 or CDPPB (mGlu2 and mGlu5 PAMs), on eNOS expression in the mouse brain and the effect of the joint administration of the ligands with nitric oxide (NO) releasers, spermineNONOate or DETANONOate, in different combinations of doses, on MK-801- or scopolamine-induced amnesia in the novel object recognition (NOR) test. Our results indicate that both compounds provoked eNOS monomer formation, and CDPPB at a dose of 5 mg/kg exaggerated the effect of MK-801 or scopolamine. The coadministration of spermineNONOate or DETANONOate enhanced the antiamnesic effect of CDPPB or LY487379. The best activity was observed for ineffective or moderate dose combinations. The results indicate that treatment with mGluR2 and mGluR5 PAMs may be burdened with the risk of promoting eNOS uncoupling through the induction of dimer dissociation. Administration of the lowest possible doses of the compounds with NO• donors, which themselves have procognitive efficacy, may be proposed for the treatment of schizophrenia or AD.