Miracle-dz/UniFAR-FTUs huggingface dataset:
The Gemini Planet Imager Exoplanet Survey: Giant Planet and Brown Dwarf Demographics from 10 to 100 au

We present a statistical analysis of the first 300 stars observed by the Gemini Planet Imager Exoplanet Survey. This subsample includes six detected planets and three brown dwarfs; from these detections and our contrast curves we infer the underlying distributions of substellar companions with respect to their mass, semimajor axis, and host stellar mass. We uncover a strong correlation between planet occurrence rate and host star mass, with stars M* > 1.5 M⊙ more likely to host planets with masses between 2 and 13MJup and semimajor axes of 3–100 au at 99.92% confidence. We fit a double power-law model in planet mass (m) and semimajor axis (a) for planet populations around high-mass stars (M* > 1.5 M⊙) of the form , finding α = −2.4 ± 0.8 and β = −2.0 ± 0.5, and an integrated occurrence rate of % between 5–13MJup and 10–100 au. A significantly lower occurrence rate is obtained for brown dwarfs around all stars, with % of stars hosting a brown dwarf companion between 13–80MJup and 10–100 au. Brown dwarfs also appear to be distributed differently in mass and semimajor axis compared to giant planets; whereas giant planets follow a bottom-heavy mass distribution and favor smaller semimajor axes, brown dwarfs exhibit just the opposite behaviors. Comparing to studies of short-period giant planets from the radial velocity method, our results are consistent with a peak in occurrence of giant planets between ∼1 and 10 au. We discuss how these trends, including the preference of giant planets for high-mass host stars, point to formation of giant planets by core/pebble accretion, and formation of brown dwarfs by gravitational instability.
Fidelity of optically controlled single‐ and two‐qubit operations on Coulomb‐coupled quantum dots

We investigate the effect of the Coulomb interaction on the applicability of quantum gates on a system of two Coulomb‐coupled quantum dots. We calculate the fidelity for a single‐ and a two‐qubit gate and the creation of Bell states in the system. The influence of radiative damping is also studied. We find that the application of quantum gates based on the Coulomb interaction leads to significant input state‐dependent errors which strongly depend on the Coulomb coupling strength. By optimizing the Coulomb matrix elements via the material and the external field parameters, error rates in the range of 10−3 can be reached. Radiative dephasing is a more serious problem and typically leads to larger errors on the order of 10−2 for the considered gates. In the specific case of the generation of a maximally entangled Bell state, error rates in the range of 10−3 can be achieved even in the presence of radiative dephasing.
MycelioTronics: Fungal mycelium skin for sustainable electronics

Electronic devices are irrevocably integrated into our lives. Yet, their limited lifetime and often improvident disposal demands sustainable concepts to realize a green electronic future. Research must shift its focus on substituting nondegradable and difficult-to-recycle materials to allow either biodegradation or facile recycling of electronic devices. Here, we demonstrate a concept for growth and processing of fungal mycelium skins as biodegradable substrate material for sustainable electronics. The skins allow common electronic processing techniques including physical vapor deposition and laser patterning for electronic traces with conductivities as high as 9.75 ± 1.44 × 104 S cm−1. The conformal and flexible electronic mycelium skins withstand more than 2000 bending cycles and can be folded several times with only moderate resistance increase. We demonstrate mycelium batteries with capacities as high as ~3.8 mAh cm−2 used to power autonomous sensing devices including a Bluetooth module and humidity and proximity sensor.
Progression of endolymphatic hydrops and vertigo during treatment in Meniere’s disease

Abstract Background Patients with Meniere’s disease (MD) receive treatment to reduce vertigo. Purpose To explore the fluctuation of vertigo symptoms and the changes in endolymphatic hydrops (EHs) in MD patients during long-term regular medication. Materials and methods We enrolled MD patients who had received two magnetic resonance imaging with intravenous contrast agents. Results Of the 42 patients in the study, 18(42.9%) had progressive EHs and 3(7.1%) had remission. The change value of the signal intensity ratio (SIR; cochlear perilymph/cerebellum) on the affected side (1.2) was larger than that on the healthy side (0.9), but there was no statistical difference. Among the 30 patients followed up, two patients had complete control of vertigo, two patients had substantial control, and three patients had worse control. The other 23 patients had insignificant control of vertigo symptoms before and after treatment. The correlation between the progression of cochlear and vestibular hydrops and the improvement of vertigo symptoms in MD patients was not significant. Conclusions and significance In treated patients with MD, EHs may progress or relieve over the long course of the disease. But there was no correlation between the development of EHs and changes in vertigo symptoms.
Embedded cognitive and emotional/affective self-reported symptom validity indices on the patient competency rating scale

ABSTRACT Objective Although there is an abundance of research on stand-alone and embedded performance validity tests and stand-alone symptom validity tests (SVTs), less emphasis has been placed on embedded SVTs. The goal of the current study was to examine the ability of embedded indicators within the Patient Competency Rating Scale (PCRS) to separately detect invalid cognitive and/or emotional/affective symptom responding. Method Participants included 299 veterans assessed in a VA medical center epilepsy monitoring unit from 2013–2017 (mean age = 48.8 years, SD = 13.5 years). Two SVT composites were created; self-reported cognitive symptom validity (SVT-C) and self-reported emotional/affective symptom validity (SVT-E). Groups were compared on PCRS total and index scores (i.e., cognitive, activities of daily living, emotional, and interpersonal competencies) using ANOVAs. Receiver operating characteristic (ROC) curve analyses assessed the classification accuracy of the PCRS total and index scores for SVT-C and SVT-E. Results In ANOVAs, SVT-C was significantly associated with all PCRS indices, while SVT-E was only significantly associated with the PCRS total, emotional, and interpersonal competency indices. Although the PCRS-T ≤ 90 had the strongest classification of SVT-C and SVT-E (specificities: .90, sensitivities: .44 to .50), PCRS index scores showed suggestive evidence of domain specificity, with PCRS-ADL ≤22, PCRS-C ≤ 20, and PCRS-CADL ≤45 best classifying SVT-C (specificities: .92, sensitivities: .33) and the PCRS-E ≤ 18 best classifying the SVT-E group (specificity: .93, sensitivity: .40). Conclusion Results suggest the PCRS may be used to obtain clinically useful information while including embedded indicators that can assess cognitive and/or emotional/affective symptom invalidity.
Extended human papillomavirus genotype distribution in cervical intraepithelial neoplasia and cancer: Analysis of 40 352 cases from a large academic gynecologic center in China

Our aim was to conduct a large epidemiologic analysis of the distribution of human papilloma virus (HPV) genotypes associated with cervical neoplasias and cancers at a major Chinese gynecologic center. The pathologic database was searched for cervical histopathologic diagnoses with prior HPV genotyping from liquid cervical cytology specimens obtained ≤6 months before biopsy. HPV testing was performed by using the Tellgenplex HPV27 or YanengBio HPV23 genotyping assays. A total of 40 352 cases meeting study criteria were identified. High risk human papillomavirus (hrHPV) was detected in 94.1% of squamous cancers compared to in only 83.3% of cervical adenocarcinomas. The prevalence of multiple HPV infections was highest in cervical intraepithelial neoplasia 1 (CIN1) (33.8%) and decreased with increasing severity of squamous lesions. The distribution of HPV genotypes was similar between CIN1 and histopathologic‐negative cases. HPV16 was one of the three most common hrHPV genotypes before all histopathologic abnormalities, ranging from 72.0% for cervical cancers, 38.7% for CIN2/3/AIS, 13.1% for CIN1, and 9.1% for biopsy‐negative cases. HPV16 and HPV18 accounted for over 87.2% of detected hrHPV genotypes for all glandular intraepithelial neoplastic lesions and cancers, whereas squamous lesions did not show this pattern. 80.3% of cervical cancers were associated with genotypes covered by HPV16/18 vaccines and 89.6% with genotypes covered by 9‐valent vaccination.
Neutrino Oscillation Probabilities in Matter with Direct and Indirect Unitarity Violation in the Lepton Mixing Matrix

In the presence of both direct and indirect unitarity violation in the lepton mixing matrix, we derive a complete set of series expansion formulas for neutrino oscillation probabilities in matter of constant density. Expansions in the mass hierarchy parameter $\alpha \equiv \Delta m_{21}^{2} / \Delta m_{31}^{2}$ and those unitarity violation parameters $s^{2}_{ij}$ (for i = 1, 2, 3 and j = 4, 5, 6) up to the first order are studied in this paper. We analyse the accuracy of the analytical series expansion formulas in different regions of L / E. A detailed numerical analysis is also performed, of which the different effects of the direct and the indirect unitarity violation are particularly emphasized. We also study in this paper the summed $\nu^{}_{\alpha} \rightarrow \nu^{}_{e, \nu, \tau}$ probabilities, whose deviation from the unity provides a definite signal of the unitarity violation.
Current flow and pair creation at low altitude in rotation-powered pulsars’ force-free magnetospheres: space charge limited flow

We report the results of an investigation of particle acceleration and electron-positron plasma generation at low altitude in the polar magnetic flux tubes of rotation-powered pulsars, when the stellar surface is free to emit whatever charges and currents are demanded by the force-free magnetosphere. We apply a new 1D hybrid plasma simulation code to the dynamical problem, using Particle-in-Cell methods for the dynamics of the charged particles, including a determination of the collective electrostatic fluctuations in the plasma, combined with a Monte Carlo treatment of the high-energy gamma-rays that mediate the formation of the electron-positron pairs.We assume the electric current flowing through the pair creation zone is fixed by the much higher inductance magnetosphere, and adopt the results of force-free magnetosphere models to provide the currents which must be carried by the accelerator. The models are spatially one dimensional, and designed to explore the physics, although of practical relevance to young, high-voltage pulsars. We observe novel behaviour (a) When the current density j is less than the Goldreich-Julian value (0 1), the system develops high voltage drops (TV or greater), causing emission of curvature gamma-rays and intense bursts of pair creation. The bursts exhibit limit cycle behaviour, with characteristic time-scales somewhat longer than the relativistic fly-by time over distances comparable to the polar cap diameter (microseconds). (c) In return current regions, where j/j(sub GJ) < 0, the system develops similar bursts of pair creation. These discharges are similar to those encountered in previous calculations by Timokhin of pair creation when the surface has a high work function and cannot freely emit charge. In cases (b) and (c), the intermittently generated pairs allow the system to simultaneously carry the magnetospherically prescribed currents and adjust the charge density and average electric field to force-free conditions. We also elucidate the conditions for pair creating beam flow to be steady (stationary with small fluctuations in the rotating frame), finding that such steady flows can occupy only a small fraction of the current density parameter space exhibited by the force-free magnetospheric model. The generic polar flow dynamics and pair creation are strongly time dependent. The model has an essential difference from almost all previous quantitative studies, in that we sought the accelerating voltage (with pair creation, when the voltage drops are sufficiently large; without, when they are small) as a function of the applied current.
Transitioning immunotherapy in neuromyelitis optica spectrum disorder – when and how to switch

ABSTRACT Introduction Newly approved immunotherapies for neuromyelitis optica spectrum disorder (NMOSD) have transformed the treatment landscape and improved disability outcomes. However, there are many remaining questions regarding transitioning immunotherapies in NMOSD that have not been addressed by randomized controlled trials. Areas covered This review focuses on the practical questions of managing and switching immunotherapies for NMOSD, including how to transition between immunotherapies, deciding when and if therapy should be discontinued, and transitioning during pregnancy or breastfeeding. Expert opinion Clinical experience and retrospective studies of real-world outcomes and complications associated with therapy, as well as therapy transitions, will help inform practice patterns moving forward. Strategies for transitioning between immunotherapies should consider the pharmacokinetics and the onset of clinical efficacy for each drug. Despite all the currently approved preventative immunotherapies, there are limited treatment options for those suffering from significant disability after their initial attack, and remyelination therapies are an important area for future research.
The core size of the Fornax dwarf Spheroidal

We exploit the detection of three distinct stellar subpopulations in the red giant branch of the Fornax dwarf Spheroidal to probe its density distribution. This allows us to resolve directly the evolution with radius of the dark matter mass profile. We find that a cored dark matter halo provides a perfect fit to the data, being consistent with all three stellar populations well within 1-sigma, and for the first time we are able to put constraints on the core size of such a halo. With respect to previous work, we do not strengthen the statistical exclusion of a dark matter cusp in Fornax, but we find that Navarro-Frenk-White haloes would be required to have unrealistically large scale radii in order to be compatible with the data, hence low values of the concentration parameter. We are then forced to conclude that the Fornax dwarf Spheroidal sits within a dark matter halo having a constant density core, with a core size of between 0.6 and 1.8 kpc.
Swallowing outcomes in dysphagia interventions in Parkinson’s disease: a scoping review

Objectives To identify all outcomes, their definitions, outcome measurement instruments (OMIs), timepoints and frequency of measurement applied in clinical trials in oropharyngeal dysphagia (OD) interventions in Parkinson’s disease (PD). This scoping review is the first stage of a larger project establishing a core outcome set for dysphagia interventions in Parkinson’s disease (COS-DIP). Design Scoping review. Methods Six electronic databases and one trial registry were searched without language restrictions until March 2022. Bibliography lists of included studies were also reviewed. Study screening and data extraction were conducted independently by two reviewers using Covidence. The scoping review protocol is registered and published (http://hdl.handle.net/2262/97652). Results 19 studies with 134 outcomes were included. Trial outcomes were mapped to a recommended taxonomy for COSs and merged. 39 outcomes were identified. The most frequently measured were general swallowing-related outcomes, global quality-of-life outcomes and swallowing-related perceived health status outcomes. The applied outcomes, their definitions, OMIs, timepoints and frequency of measurement showed a high variability across all studies. Conclusions The high variability of outcomes emphasises the need for an agreed standardised COS. This will inform clinical trial design in OD in PD, increase the quality of OD trials in PD and facilitate synthesising and comparing study results to reach conclusion on the safety and effectiveness of OD interventions in PD. It will not prevent or restrict researchers from examining other outcomes. Trial registration number The COS-DIP study, including the scoping review, was registered prospectively with the Core Outcome Measures in Effectiveness Trials Database on 24 September 2021 (www.comet-initiative.org, registration number: 1942).
Effect of an atom on a quantum guided field in a weakly driven fiber-Bragg-grating cavity

We study the interaction of an atom with a quantum guided field in a weakly driven fiber-Bragg-grating (FBG) cavity. We present an effective Hamiltonian and derive the density-matrix equations for the combined atom-cavity system. We calculate the mean photon number, the second-order photon correlation function, and the atomic excited-state population. We show that due to the confinement of the guided cavity field in the fiber cross-section plane and in the space between the FBG mirrors, the presence of the atom in the FBG cavity can significantly affect the mean photon number and the photon statistics even though the cavity finesse is moderate, the cavity is long, and the probe field is weak.
Socioeconomic inequality in cancer in the Nordic countries. A systematic review

Abstract Background Despite structural and cultural similarities across the Nordic countries, differences in cancer survival remain. With a focus on similarities and differences between the Nordic countries, we investigated the association between socioeconomic position (SEP) and stage at diagnosis, anticancer treatment and cancer survival to describe patterns, explore underlying mechanisms and identify knowledge gaps in the Nordic countries Methods We conducted a systematic review of population based observational studies. A systematic search in PubMed, EMBASE and Medline up till May 2021 was performed, and titles, abstracts and full texts were screened for eligibility by two investigators independently. We extracted estimates of the association between SEP defined as education or income and cancer stage at diagnosis, received anticancer treatment or survival for adult patients with cancer in the Nordic countries. Further, we extracted information on study characteristics, confounding variables, cancer type and results in the available measurements with corresponding confidence intervals (CI) and/or p-values. Results were synthesized in forest plots. Results From the systematic literature search, we retrieved 3629 studies, which were screened for eligibility, and could include 98 studies for data extraction. Results showed a clear pattern across the Nordic countries of socioeconomic inequality in terms of advanced stage at diagnosis, less favorable treatment and lower cause-specific and overall survival among people with lower SEP, regardless of whether SEP was measured as education or income. Conclusion Despite gaps in the literature, the consistency in results across cancer types, countries and cancer outcomes shows a clear pattern of systematic socioeconomic inequality in cancer stage, treatment and survival in the Nordic countries. Stage and anticancer treatment explain some, but not all of the observed inequality in overall and cause-specific survival. The need for further studies describing this association may therefore be limited, warranting next step research into interventions to reduce inequality in cancer outcomes. Study registration Prospero protocol no: CRD42020166296
VARIATIONS BETWEEN DUST AND GAS IN THE DIFFUSE INTERSTELLAR MEDIUM

Using the Planck far-infrared and Arecibo GALFA 21 cm line surveys, we identified a set of isolated interstellar clouds (approximately degree-sized on the sky and comprising 100 solar masses) and assessed the ratio of gas mass to dust mass. Significant variations of the gas/dust ratio are found both from cloud to cloud and within regions of individual clouds; within the clouds, the atomic gas per unit dust decreases by more than a factor of 3 compared with the standard gas/dust ratio. Three hypotheses are considered. First, the apparently low gas/dust ratio could be due to molecular gas. Comparing to Planck CO maps, the brightest clouds have a H2/CO ratio comparable to Galactic plane clouds, but a strong lower limit is placed on the ratio for other clouds, such that the required amount of molecular gas is far higher than would be expected based on the CO upper limits. Second, we consider self-absorbed 21 cm lines and find that the optical depth must be ∼3, significantly higher than found from surveys of radio sources. Third, grain properties may change within the clouds: they become more emissive when they are colder, while not utilizing heavy elements that already have their cosmic abundance fully locked into grains. It is possible that all three processes are active, and follow-up studies will be required to disentangle them and measure the true total gas and dust content of interstellar clouds.
2MTF – II. New Parkes 21-cm observations of 303 southern galaxies

We present new 21-cm neutral hydrogen (H i) observations of spiral galaxies for the 2MASS Tully–Fisher (2MTF) survey. Using the 64-m Parkes radio telescope multibeam system we obtain 152 high signal-to-noise ratio H i spectra from which we extract 148 high-accuracy (<5 per cent error) velocity widths and derive reliable rotation velocities. The observed sample consists of 303 southern (δ < −40°) galaxies selected from the 2MASS Redshift Survey with Ks < 11.25 mag, cz < 10 000 km s−1 and axis ratio b/a < 0.5. The H i observations reported in this paper will be combined with new H i spectra from the Green Bank and Arecibo telescopes, together producing the most uniform Tully–Fisher survey ever constructed (in terms of sky coverage). In particular, due to its near-infrared selection, 2MTF will be significantly more complete at low Galactic latitude (|b| < 15°) and will provide a more reliable map of peculiar velocities in the local Universe.
Preprint typeset in JHEP style-HYPER VERSION Note on Zero Temperature Holographic Superfluids

In this note, we have addressed various issues on zero temperature holographic superfluids. First, inspired by our numerical evidence for the equality between the superfluid density and particle density, we provide an elegant analytic proof for this equality by a boost trick. Second, using not only the frequency domain analysis but also the time domain analysis from numerical relativity, we identify the hydrodynamic normal modes and calculate out the sound speed, which is shown to increase with the chemical potential and saturate to the value predicted by the conformal field theory in the large chemical potential limit. Third, the generic non-thermalization is demonstrated by the fully non-linear time evolution from a nonequilibrium state for our zero temperature holographic superfluid. Furthermore, a conserved Noether charge is proposed in support of this behavior. ar X iv :1 60 2. 03 82 4v 1 [ he pth ] 1 1 Fe b 20 16
Surgical management of injured ADF personnel deployed to Afghanistan 2001–2021

A comprehensive review of the surgical management of injuries sustained by deployed members of the Australian Defence Force (ADF) during Operation SLIPPER and HIGHROAD in Afghanistan has not previously been undertaken. Understanding the mechanism of injury, injury types sustained and surgical intervention undertaken should provide valuable information for future health planning and surgical capability determination.