Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Xiaoyutang Combined with Intraperitoneal Heat Perfusion Chemotherapy on Immune Function, Circulating mir, Prognosis, and Survival of Postoperative Patients with Colorectal Cancer

Objective To explore the effects of Xiaoyutang combined with intraperitoneal heat perfusion chemotherapy on immune function, circulating Mir, and prognosis and survival of postoperative patients with colorectal cancer. Methods A total of 96 patients with colorectal cancer who were treated in our hospital from May 2018 to August 2019 and followed up to August 2021 were selected as the study subjects. The patients were randomly divided into a control group and study group by a 1 : 1 random number table method, 48 cases in each group. Patients in the control group were given intraperitoneal thermal perfusion chemotherapy after surgery, and patients in the research group were treated with Xiaoyutang on this basis. The treatment cycle was 21 days, and all patients were treated for 3 consecutive cycles. The therapeutic efficacy, immune function (CD3+, CD4+, and CD4+/CD8+), circulating mir (mir-29a, mir-145, and mir-92a), prognosis, and survival of the two groups were compared. Results After 3 cycles of treatment, ORR and DCR in the study group were higher than those in the control group (60.42% vs. 37.50%) and 85.42% vs. 66.67%, respectively, with statistical significance (P < 0.05). There were statistically significant differences in CD3+, CD4+, CD4+/CD8+, mir-29a, mir-145, and mir-92a time points and intergroup and intergroup interactions between the two groups (P < 0.05); the levels of CD3+, CD4+, and CD4+/CD8+ in the study group were higher than those in the control group after 1, 2, and 3 cycles of treatment (P < 0.05); the expressions of mir-29a, mir-145, and mir-92a were significantly lower than those in the control group (P < 0.05). By the end of follow-up, 3 cases were lost to follow-up in the study group and 5 cases in the control group. The recurrence rate and mortality of the study group were lower than those of the control group at 1- and 2-year follow-up (P > 0.05), and the mean survival time of patients in the study group was higher than that in the control group; the differences were statistically significant (χ2 = 5.151, P = 0.023). Conclusion Xiaoyutang combined with peritoneal heat perfusion chemotherapy has a good postoperative effect on patients with colorectal cancer, which can effectively improve the immune function and circulating Mir of patients with colorectal cancer, reduce tumor recurrence, and improve the prognosis of patients.
Externalización de procesos de negocio en tecnologías de la información y la gestión estratégica del conocimiento. Una revisión de la literatura * Business process outsourcing in information technology and strategic management of knowledge. A literature review

The purpose of this literature review is to know if there's relationship between the business process outsourcing (BPO) in the area of information technology (IT) and strategic management of knowledge (SMK). The study allowed establishing the main approaches from the 80's until present times marking the investigative focus on both areas. From the theoretical point of view, the principal contribution of the study is the entailment of two conceptual frames (Business Process Outsourcing and Strategic Knowledge Management), that have barely been treated together in preceding investigations about the subject. From the practical point of view, the findings identify that BPO in IT has direct and indirect effects in the interior of organizations, that it influences of way positive and negative in the SMK to obtain competitiveness and thereby business success.
Reviewing Four Decades of Cell Phone Use while Driving Literature (1970-2010): An Emphasis on Texting Behaviors, Parental Perceptions, and Methods of Control

Background: Cell phone use while driving is identified as a contributing factor in a growing number of vehicular crashes. As the technology becomes more mainstream and users become more technologically dependent the need to reduce distraction-related risk while operating a motor vehicle also increases. Objective: To inventory and organize the peer-reviewed literature related to cell phone use while driving in terms of the effectiveness of various control efforts and to identify shifts in research focus from risk evaluation to intervention and reduction. Methods: A thorough review of the peer-reviewed literature was conducted to retrieve empirical articles that addressed cell phone use behaviors while driving. A matrix was constructed to determine the quantity, quality, and characteristics of 74 research studies conducted between 1970 and 2010 pertaining to cell phone use and texting behaviors. Results: A synthesis of these empirical articles revealed an emerging literature related to text messaging while driving behaviors and limited information focusing on methods of control. Conclusions: Amid growing trends of cell phone use and text messaging while driving in the United States, further research is needed to fill literature gaps pertaining to appropriate strategies and techniques to minimize risky behaviors in an increasingly technology-reliant population.
New Candidates for Autism/Intellectual Disability Identified by Whole-Exome Sequencing

Intellectual disability (ID) is characterized by impairments in the cognitive processes and in the tasks of daily life. It encompasses a clinically and genetically heterogeneous group of neurodevelopmental disorders often associated with autism spectrum disorder (ASD). Social and communication abilities are strongly compromised in ASD. The prevalence of ID/ASD is 1–3%, and approximately 30% of the patients remain without a molecular diagnosis. Considering the extreme genetic locus heterogeneity, next-generation sequencing approaches have provided powerful tools for candidate gene identification. Molecular diagnosis is crucial to improve outcome, prevent complications, and hopefully start a therapeutic approach. Here, we performed parent–offspring trio whole-exome sequencing (WES) in a cohort of 60 mostly syndromic ID/ASD patients and we detected 8 pathogenic variants in genes already known to be associated with ID/ASD (SYNGAP1, SMAD6, PACS1, SHANK3, KMT2A, KCNQ2, ACTB, and POGZ). We found four de novo disruptive variants of four novel candidate ASD/ID genes: MBP, PCDHA1, PCDH15, PDPR. We additionally selected via bioinformatic tools many variants in unknown genes that alone or in combination can contribute to the phenotype. In conclusion, our data confirm the efficacy of WES in detecting pathogenic variants of known and novel ID/ASD genes.
Experimental evaluation of anti-inflammatory effect of ethanolic extract of Vanilla planifolia seeds in Wistar rats

Background: Inflammation is a protective response of the body to the harmful stimuli. Inflammation can be either acute or chronic, always associated pain, redness and loss of function. Vanilla planifolia (VP) is the aromatic plant, as per literature, it has anti-inflammatory activity, which has not been tested as per modern medicinal parameters. Non-steroidal anti-inflammatory drugs are commonly used for the treatment but have many adverse effects such as gastritis, hepatitis etc. Therefore, there is always a search for new safe drug. Aim and Objectives: The aim of the study is to evaluate the anti-inflammatory activity of VP seeds in acute and chronic animal model of inflammation. Materials and Methods: Rats weighing 150–200 g of either sex were included in the study. Acute Anti-inflammatory activity tested with carrageenan-induced paw edema and chronic with cotton pellet-induced granuloma model. Animals were divided into five groups – Gr-I Control, Gr-II Vehicle control, Gr-III Diclofenac sodium, Gr-IV (VPLD), Gr-V (VPHD). Drug treatment was given 1 h before carrageenan injection. Paw volume measured at different time interval with plethysmometer. In chronic model, drug treatment was given for 7 days after pellet implantation. On 8th day, pellets removed and dried in oven. Weight of wet and dry pellets from all the groups compared with vehicle control. Data obtained was analyzed with Graph pad prism 6. Results: Reduction in paw volume started in all drug treated groups after 1 h of treatment. Paw volume was significantly reduced (P < 0.001) in group III, IV & V in 5 h. reached to near normal. In chronic model, VPLD showed decrease in wet pellet (P < 0.01) and dry pellet weight (P < 0.05) significantly. VPHD was more effective in reducing wet pellet (P < 0.001) and dry Pellet weight (P < 0.01). Similar results were seen on the left side. Conclusion: VP seed extract showed promising anti-inflammatory effect in both models of inflammation.
Application of some novel non-destructive diagnostic tests for condition assessment of stator coils and bars following voltage endurance tests

With ongoing development of novel nonpartial discharge-based test methods that show promise as diagnostic tools in the cable industry, there is an increasing interest to determine if these tests have the ability assess the condition of generator stator insulation systems. One reason for this is that after data interpretation of modern online PD measurements has identified a problem and some maintenance is performed, there is still a need to conduct some diagnostic tests to benchmark the condition of the machine. Also, utilities are recognising that there are potential limitations with simple "go" "no-go" DC or AC hipot tests. Some of the new cable diagnostic test methods such as dielectric spectroscopy, low frequency tan/spl delta/, recovery voltage method and leakage current measurements are now being considered. Before these test methods can be employed directly on generator insulation systems for condition assessment, it is important to first examine issues related to test procedures, identify the merits, and determine limitations (if any) of these test methods in a laboratory environment. This paper describes the preliminary results of work that was done at Powertech Labs using two of these diagnostic test methods. Bars/coils of different vintage and manufacture that were previously tested using conventional test methods (such as PDA, DF and VE) as well as, virgin bars/coils were recently benchmarked using dielectric spectroscopy and Powertech's LIpATEST.
Study on Spreading of Liquid Droplet Impacting on a Solid Dry Surface

A numerical computation and theoretical model are presented on spreading of a single droplet impacting on a solid surface at low Weber number. The numerical simulation uses combined Level Set-VOF method and a precise wetting model. The singularity at the moving contact line was analyzed and removed by present wetting model. A theoretical model based on the energy balance was developed to predict the maximum spreading ratio, accounting for wetting effect by a correction factor. The droplets shapes, the dimensionless spreading radius and the dimensionless height of droplet calculated by present numerical method were compared with the experimental data. The theoretical model is used to predict the maximum spreading ratio. The numerical and theoretical results agree well with the experimental data. Present theoretical model indicates that capillary effects may be neglected if 6We(We/3+4)>>Re.
Selected Method of Artificial Intelligence in Modeling Safe Movement of Ships

This paper presents one of the methods of artificial intelligence, especially neural networks, for the determination of coefficients of state equations of a ship’s safe motion in a horizontal plane. The recurrent optimization network is used to identify parameters of the ship’s dynamics. A structure and the operating principle of the network and results of computer simulation of a ship’s motion along a desired trajectory are presented in this paper as simulation trials using the MATLAB program.
A novel approach for the consideration of plastic material behavior in thermodynamic topology optimization

In order to find optimal structures for realistic applications, it is essential to include the real material behavior in the optimization process. For this purpose, this research focuses on thermodynamic topology optimization accounting for plasticity for which a surrogate material model is developed. Characteristically, the stress/strain diagram resulting from physical loading and unloading shows a hysteresis for classical plasticity models. Our material model takes only the physical loading during the optimization process into account. To this end, during a virtual unloading in the optimization process, the dissipation of energy is suppressed which yields the same elasto/plastic deformation state as for physical loading. By using this novel material model, optimized structures can be computed without resourceful classical path‐dependent plasticity computation.
A piezoelectric fibre composite based energy harvesting device for potential wearable applications

Rapid technological advances in nanotechnology, microelectronic sensors and systems are becoming increasingly miniaturized to the point where embedded wearable applications are beginning to emerge. A restriction to the widespread application of these microsystems is the power supply of relatively sizable dimensions, weight, and limited lifespan. Emerging micropower sources exploit self-powered generators utilizing the intrinsic energy conversion characteristics of smart materials. ‘Energy harvesting’ describes the process by which energy is extracted from the environment, converted and stored. Piezoelectric materials have been used to convert mechanical into electrical energy through their inherent piezoelectric effect. This paper focuses on the development of a micropower generator using microcomposite based piezoelectric materials for energy reclamation in glove structures. Devices consist of piezoelectric fibres, 90–250 µm in diameter, aligned in a unidirectional manner and incorporated into a composite structure. The fibres are laid within a single laminate structure with copper interdigitated electrodes assembled on both sides, forming a thin film device. Performances of devices with different fibre diameters and material thicknesses are investigated. Experiments are outlined that detail the performance characteristics of such piezoelectric fibre laminates. Results presented show voltage outputs up to 6 V which is considered enough for potential applications in powering wearable microsystems.
Diagnostic ions guided 2D-locating strategy for characterization of chemical analogues in complex herbal medicines using liquid chromatography-ion mobility-mass spectrometry

Rapid characterization of chemical analogues in potentially toxic complex matrix was essential for prevention of accidental poisoning. On the basis of the fragment ions possessed not only the same retention times (RT) but the same drift times (DT) on liquid chromatography-ion mobility-mass spectrometry (LC-IM-MS), an alternating frames (AF)-data independent acquisition (DIA) was utilized for simultaneous detection and rapid match of precursor/product ions with a fast switch of low/high collision energy (CE). A diagnostic ions guided 2D-locating strategy was developed for identification of chemical analogues in potentially toxic herbal medicines using LC-IM-MS. Firstly, the 2D-locations (RT, DT) of diagnostic ions were screened from high-fragment IM-MS frames according to their m/z. Then, the correlated precursor ions were extracted from the complex background interference in low-fragment IM-MS frames based on diagnostic ions’ 2D-locations. Finally, the remained ions were characterized using double-bond equivalent analysis combined with MS/MS fragment interpretation. Totally, 236 diterpene alkaloids including eight compounds with potential new esterification types were characterized in processed lateral roots of Aconitum carmichaelii Debx. Moreover, the LC-IM-MS distribution regularities of diterpene alkaloids with various chemical structure types were further investigated and discussed. This study presented an innovative idea for revealing the chemical basis related to the toxicities of potentially poisonous herbal medicines to ensure the medication safety.
Effect of Biofertilizer Phosphate on Grain Yield and Its Components of Maize (Zea mays L.) cv. KSC704 under Water Deficit Stress Conditions

سارك لگنيس ترذ تافص يخرب رب هلونارگ هتافسف يتسيز دوك رثا يسررب روظنم هب 704 يبآ مك شنت طيارش رد كولب حرط بلاق رد ليروتكاف تيلپسا تروص هب يشيامزآ ،نارهم هقظنم رد ه رد رارـكت هـس اب يفداصت لماك يا لصف رد ملايا ناتسا يعيبط عبانم و يزرواشك تاقيقحت زكرم يتاقيقحت هعرزم يـعارز ياـه 1387 و 1388 ارـجا ديدرگ . نامز لماش شيامزآ ياهراميت حطس هس رد يرايبآ ياه : زا سپ يرايبآ 70 ، 100 و 130 يـليم رـيخبت رـتم سلاك كتشت حطس زا يعمجت A يز دوك و هدافتسا ،رادرفسف يتسيز دوك زا هدافتسا مدع حطس ود رد رادرفسف يتس فرصم ،رادرفسف ييايميشدوك زا هدافتسا مدع ،حطس هس رد ييايميش دوك و رادرفسف يتسيز دوك زا 45 مرگوـليك راتكه رد P2O5 و 90 راتكه رد مرگوليك P2O5 دندوب . هك داد ناشن جياتن هـلونارگ هتافسـف يتسـيز دوك فرصم رد يبآ مك شنت طيارش ) 100 و 130 كتشت حطس زا ريخبت رتميليم ( ينعم روط هب درـكلمع يازجا ،هناد دركلمع يراد و داد شيازفا ار تشادرب صخاش . هناد دركلمع نيرتشيب ) 9090 راـتكه رد مرگوليك ( و هـنيهب يراـيبآ طيارـش رد رادقمب ييايميش دوك و يتسيز دوك فرصم 45 ب راتكه رد مرگوليك دمآ تسد . زـين ميلام يبآ مك شنت طيارش رد دركلمع نيرتشيب هناد ) 8098 راتكه رد مرگوليك ( دـش لـصاح يدوـك راميت نيمه زا . هـناد رازـه نزو نيرتلااـب ) 6 / 356 مرگ ( فرصم راميت هب طوبرم 45 راتكه رد مرگوليك P2O5 يراـيبآ طيارـش و هتافسـف يتسيز دوك اب هارمه هنيهب م اب هك دمآ تسد هب فرص 90 راتكه رد مرگوليك P2O5 دوـك فرصـم نودـب و هتافسـف يتسيز دوك فرصم و يرايبآ طيارش و ييايميش هنيهب ينعم فلاتخا دادن ناشن ار يراد . للاب فيدر رد هناد دادعت ،هناد دركلمع نيرتشيب فرصم راميت رد للاب رد فيدر دادعت و 45 راتكه رد مرگوليك P2O5 فسف يتسيز دوك اب هارمه يرايبآ طيارش و هتا هنيهب فرصم اب هك دمآ تسد هب 90 راتكه رد مرگوليك P2O5 ينعم فلاتخا دندادن ناشن ار يراد . جياتن قيقحت نيا ناشن داد هك لح يتسيز ياهدوك فرصم هدننك هاـيگ لمحت شيازفا هب رجنم تافسف رد ترذ مـك شنـت طيارـش يبآ دش ييايميش ياهدوك فرصم شهاك و .
Context-Aware Power Management

With more and more computing devices being deployed in buildings there has been a steady rise in buildings’ electricity consumption. These devices not only consume electricity but also produce heat, which increases loading on ventilation systems, further increasing electricity consumption. At the same time there is a pressing need to reduce overall building energy consumption. For example, the European Union’s strategy for security of energy supply highlights energy saving in buildings as a key target area. One approach to reducing energy consumption of devices in buildings is to improve the effectiveness of their power management. Current state-of-the-art computer power management is predominantly focused on extending battery life for mobile computing devices. The majority of policies are low-level and are used to manage sub-components within the overall computing device. The key trade-off for these policies is device performance versus increased battery life. In contrast, stationary computing devices do not have battery limitations and typically the most significant energy savings are achieved by switching the entire device to standby. However, switching to a deep standby state can cause significant user annoyance due to the relatively long resume time and possible false power downs. Consequently these energy saving features are typically not enabled (or used with long timeouts). To increase enablement, policies for stationary devices need to operate in a near transparent fashion, i.e., operate automatically and with little user-perceived performance degradation. Context-aware pervasive computing describes a vision of computing everywhere that seamlessly assists us in our daily tasks, i.e., many functions are intelligently automated. Information display, computing, sensing and communication will be embedded in everyday objects and within the environment’s infrastructure. Seamless interaction with these devices will enable a person to focus on their task at hand while the devices themselves vanish into the background. Realisation of this vision could exacerbate the building energy problem as more stationary computing devices are deployed but it could also provide a solution. Context information (e.g., user location information) likely to be available in such pervasive computing environments could enable highly effective power management for
Intelligent control system for 6000 m deep towed system

In this paper, intelligent control is employed to tackle the movement control problems of a 6000 m deep towed system. First, the dynamic response of the 6000 m deep towed system is analyzed. Then, an intelligent control system using the adaptive neural network is proposed, and the learning control algorithm is given. Finally, results of the movement control of the 6000 m deep towed system are discussed.
Synchronizing the retail supply chain

textabstractDit proefschrift ontwerpt een retail supply chain, die beter en goedkoper is dan de gangbare. Dit wordt bereikt door de distributie te synchroniseren op de productie¬momenten. Goederen zouden direct uit productie al stroomafwaarts moeten bewegen, van fabrikant naar retailer, tegen lage kosten, in volle pallets en in volle auto’s en in hoeveel¬heden die groot genoeg zijn om de vraag tot het volgende productiemoment te dekken. Door de formules van de "Krantenverkoper" en die van de economische ordergrootte (EOQ) aan te passen aan een multi-echelon divergerend distributienetwerk, kan ook theoretisch worden bewezen dat het stroomafwaarts positioneren van voorraden inderdaad optimaal is en dat de voorraden daardoor zullen dalen. De huidige magazijnen van de leveranciers kunnen worden gereduceerd tot overslagpunten, waar goederen van de verschillende fabrieken van een leverancier worden samengebracht om rijden met vollere vrachtwagens mogelijk maken. Kleinere hoeveelheden kunnen leveranciers beter afleveren bij het dichtstbijzijnde distributiecentrum van een retailer, waarna de retailer zelf het deel met bestemming elders verder vervoert. Tenslotte kan de winkelbevoorrading worden aangepast aan de schapruimte, waardoor de werkwijze in de distributiecentra kan worden gerationaliseerd.
A compact multiband antenna based on CRLH‐TL ZOR for wireless mobile system

A compact multiband antenna using a composite right/left‐handed transmission line (CRLH‐TL) zeroth‐order resonator (ZOR) for global system for mobile communications (GSM900/1800/1900, 880‐960/1710‐1880/1850‐1990 MHz), wideband code division multiple access (WCDMA, 1920–2170 MHz), and wireless broadband (WiBro, 2.3–2.4 GHz) operations is presented. The proposed antenna having a total volume of 35 mm × 5 mm × 3 mm comprises a lower band ZOR antenna part and an upper band ZOR antenna part. The zeroth‐order resonant properties are described and analyzed using dispersion diagrams based on the CRLH‐TL ZOR theory and the full‐wave simulation. The radiation patterns are the same as the omnidirectional characteristics and the maximum gains are 1.64, 2.47, and 3.32 dBi at 0.92, 1.88, and 2.2 GHz, respectively. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2852–2855, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24799