Miracle-dz/UniFAR-FTUs huggingface dataset:
Minimally Invasive Treatment of Lateral Incisors with Guided One-Piece or Two-Piece Titanium-Made Narrow Diameter Implants: A Retrospective Comparative Study with Up to Two Years Follow-Up

Restoring teeth with dental implants has become the gold standard in recent years, especially in the esthetic zone. However, limited amount of available bone as well as limited interdental space in the anterior zone may create problems for implant treatment. Narrow diameter implants (NDI) may be a treatment option to resolve the above-mentioned limitations and providing minimally invasive implant therapy without additional regenerative procedures. In this retrospective study, a comparison of clinical and radiographic outcomes between one-piece and two-piece titanium-made NDIs was done with the follow-up of two years after loading. Twenty-three NDI cases were analyzed, 11 in the one-piece implant group (group one) and 12 in the two-piece implant group (group two). The outcomes were implant and prosthetic failures, any complications occurred, peri-implant bone level changes, and as well as the Pink Esthetic score. No implant or prosthetic failures, as well as, no complications were reported at the two-year follow-up examination. At the same time the marginal bone loss was 0.23 ± 0.11 in the group one and 0.18 ± 0.12 in the group two. Difference was not statistically significant (p = 0.3339). The Pink Esthetic Score, recorded two years after definitive loading, was 12.6 ± 0.97 in the group one and 12.2 ± 0.92 in the group two, with no statistically significant difference between groups (p = 0.3554). With the limitations of the present study, including the small sample size and short follow-up, it is possible to conclude that either one and two-piece NDI can be successfully used to restore lateral incisors with comparable results within the two years of follow-up.
Management of Saline-Sodic Soil through Press Mud and Sulfur Application for Wheat-Pearl Millet Cropping System

Press mud is a nutrient-rich organic residue and elemental sulfur being a reclamation agent in combination or alone can be used for rehabilitation of salt-affected soils on wheat-pearl millet crops. The results of present study revealed that press mud and sulfur hold excellent potential to reclaim the saline-sodic soil and alleviate the salinity stress in wheat and pearl millet crops. However, integrated use of sulfur (S) and press mud (PM) demonstrated the positive effects on soil health and crop resilience. Application of S @ 50% gypsum requirement (GR) with PM @ 10 t ha-1 showed better results than all other treatments and increased the plant height, number of tillers, spike length, 1000 grain weight, straw yield and grain yield of wheat by 11.16%, 9.87%, 27.93%, 15.65%, 33.54% and 50.26% respectively. Same trend was observed in pearl millet and the plant height, number of tillers, panicle length, grain panicle-1, 1000 grain weight, and grain yield were increased by 16.66%, 22.85%, 13.11%, 9.74%, 13.64%, and19.37% respectively over control. Integrated use of sulfur and press mud also ameliorated the soil properties and reduced the soil pH (4.57%), EC (15.26%), SAR (56.26%), and BD (10.11%) and increased HC (32.5%). Therefore, the integrated sulfur application @ 50% GR and press mud @ 10 t ha-1 are recommended as an effective reclamation strategy to manage the saline-sodic soil for better productivity of wheat and pearl millet crops.
Injury to Cone Synapses by Retinal Detachment: Differences from Rod Synapses and Protection by ROCK Inhibition

Attachment of a detached retina does not always restore vision to pre-injury levels, even if the attachment is anatomically successful. The problem is due in part to long-term damage to photoreceptor synapses. Previously, we reported on damage to rod synapses and synaptic protection using a Rho kinase (ROCK) inhibitor (AR13503) after retinal detachment (RD). This report documents the effects of detachment, reattachment, and protection by ROCK inhibition on cone synapses. Conventional confocal and stimulated emission depletion (STED) microscopy were used for morphological assessment and electroretinograms for functional analysis of an adult pig model of RD. RDs were examined 2 and 4 h after injury or two days later when spontaneous reattachment had occurred. Cone pedicles respond differently than rod spherules. They lose their synaptic ribbons, reduce invaginations, and change their shape. ROCK inhibition protects against these structural abnormalities whether the inhibitor is applied immediately or 2 h after the RD. Functional restoration of the photopic b-wave, indicating cone-bipolar neurotransmission, is also improved with ROCK inhibition. Successful protection of both rod and cone synapses with AR13503 suggests this drug will (1) be a useful adjunct to subretinal administration of gene or stem cell therapies and (2) improve recovery of the injured retina when treatment is delayed.
Phenotypic Array for Identification and Screening of Antifungals against Aspergillus Isolates from Respiratory Infections in KwaZulu Natal, South Africa

The rapid emergence of invasive fungal infections correlates with the increasing population of immunocompromised individuals, with many cases leading to death. The progressive increase in the incidence of Aspergillus isolates is even more severe due to the clinical challenges in treating invasive infections in immunocompromised patients with respiratory conditions. Rapid detection and diagnosis are needed to reduce mortality in individuals with invasive aspergillosis-related infections and thus efficient identification impacts clinical success. The phenotypic array method was compared to conventional morphology and molecular identification on thirty-six Aspergillus species isolated from patients with respiratory infections at the Inkosi Albert Luthuli Hospital in Kwa-Zulu Natal. In addition, an antimicrobial array was also carried out to screen for possible novel antimicrobial compounds for treatment. Although traditional morphological techniques are useful, genetic identification was the most reliable, assigning 26 to Aspergillus fumigatus species, 8 Aspergillus niger, and 2 Aspergillus flavus including cryptic species of A. niger, A. tubingensis and A. welwitschiae. The phenotypic array technique was only able to identify isolates up to the genus level due to a lack of adequate reference clinical species in the database. However, this technique proved crucial in assessing a wide range of possible antimicrobial options after these isolates exhibited some resistance to azoles. Antifungal profiles of the thirty-six isolates on the routine azole voriconazole showed a resistance of 6%, with 61% having moderate susceptibility. All isolates resistant to the salvage therapy drug, posaconazole pose a serious concern. Significantly, A. niger was the only species resistant (25%) to voriconazole and has recently been reported as the species isolated from patients with COVID-19-associated pulmonary aspergillosis (CAPA). Phenotypic microarray showed that 83% of the isolates were susceptible to the 24 new compounds and novel compounds were identified for potentially effective combination treatment of fungal infections. This study also reports the first TR34/98 mutation in Aspergillus clinical isolates which is located in the cyp51A gene.
Exploring the Chemical Composition and Antioxidant Properties of Apricot Kernel Oil

Apricot kernels are known to be rich in bioactive compounds such as polyphenols, which have applications in various fields such as cosmetology and the food industry. However, the extraction of these compounds has not been extensively studied. In this study, we aimed to extract oil from apricot kernels and investigate its composition and antioxidant properties. Samples from two years of apricot cannery by-products were used in the study. We employed a common extraction procedure using hexane as a solvent, followed by an analysis of the oil’s fatty acid composition and determination of its antioxidant properties using several methods. Our results indicated that the oil extracted from apricot kernels is rich in oleic and palmitoleic acids, which exhibit health benefits. As regards the volatile compounds of the oil, 2-methyl propanal, benzaldehyde, and benzyl alcohol were detected as the main compounds. Benzaldehyde was also found to be the main component of the essential oil of the kernel. Furthermore, the oil exhibited low antioxidant activity, as demonstrated by its ability to scavenge free radicals. Overall, our findings suggest that apricot kernels are a valuable source of oil with potential applications in the food and cosmetic industries.
Papel de la Educación Superior para el Desarrollo de Emprendimientos y Emprendedores

Este artículo examina el papel de la educación superior en el desarrollo de emprendimientos y emprendedores. El objetivo principal es analizar la literatura existente sobre este tema y proporcionar una visión integral de los impactos, estrategias, factores, contribuciones y retos de la educación emprendedora en el contexto de la educación superior. La metodología utilizada se basó en una revisión sistemática de artículos publicados en bases de datos académicas en español. Se identificaron estudios que cumplieran con los criterios de inclusión y se realizó un análisis temático de los mismos. Los principales hallazgos revelan que la educación superior tiene un impacto positivo en el desarrollo de emprendimientos y emprendedores, proporcionando conocimientos, habilidades y actitudes emprendedoras. Además, se identificaron estrategias y métodos efectivos para fomentar el emprendimiento en la educación superior, como programas de educación emprendedora y enfoques de aprendizaje experiencial. Asimismo, se destacó la importancia de factores contextuales, como el contexto socioeconómico y cultural, en la eficacia de la educación emprendedora. Se resalta el papel de las universidades en el desarrollo de ecosistemas emprendedores y se enfatiza la necesidad de un enfoque más inclusivo y sostenible del emprendimiento.
A vision monitoring system for multipoint deflection of large‐span bridge based on camera networking

This paper proposes a vision monitoring system for multipoint deflection of a large‐span bridge that can well compensate the camera motion–induced errors. The camera network system (CNS) consists of a series of dual‐camera stations that are linked with the cooperative markers. The infrared illumination supplement device is integrated in the camera station and the regular double‐sided prism is selected as the cooperative marker to realize 24‐h continuous monitoring. The feasibility and efficiency of CNS are verified by conducting a field test inside the steel box girders of a suspension bridge with a length of 1038 m. The results show that the proposed camera networking method can well solve the problem of the large‐scale high‐precision monitoring under unstable measuring platform. For the kilometer‐level flexible bridge, CNS can meet submillimeter precision in quasi‐static measurement, and can also provide deflection data similar to the conventional robotic total station and connecting pipe system in long‐term monitoring. The geometric alignment of large‐span bridges with dense multimeasuring points can be automatically monitored and recorded by CNS. The observed deflections of the studied suspension bridge are dominated with the vehicle load and wind load in the short term and are correlated with the temperature change in the long term. The proposed CNS can provide a new option for the bridge deflection monitoring and provide new parameters for bridge safety evaluation.
PeGSTU58, a Glutathione S-Transferase from Populus euphratica, Enhances Salt and Drought Stress Tolerance in Transgenic Arabidopsis

Glutathione S-transferases (GSTs) play a crucial role in responding to abiotic stress and are an important target for research on plant stress tolerance mechanisms. Populus euphratica is a promising candidate species for investigating the abiotic tolerance mechanisms in woody plants. In our previous study, PeGSTU58 was identified as being associated with seed salinity tolerance. In the present study, PeGSTU58 was cloned from P. euphratica and functionally characterized. PeGSTU58 encodes a Tau class GST and is located in both the cytoplasm and nucleus. Transgenic Arabidopsis overexpressing PeGSTU58 displayed enhanced tolerance to salt and drought stress. Under salt and drought stress, the transgenic plants exhibited significantly higher activities of antioxidant enzymes, including SOD, POD, CAT, and GST, compared to the wild-type (WT) plants. Additionally, the expression levels of several stress-responsive genes, including DREB2A, COR47, RD22, CYP8D11, and SOD1 were upregulated in PeGSTU58 overexpression lines compared to those in WT Arabidopsis under salt and drought stress conditions. Furthermore, yeast one-hybrid assays and luciferase analysis showed that PebHLH35 can directly bind to the promoter region of PeGSTU58 and activate its expression. These results indicated that PeGSTU58 was involved in salt and drought stress tolerances by maintaining ROS homeostasis, and its expression was positively regulated by PebHLH35.
A Simple Test for Dynamic Causality in Panel Data

A new panel data test for Granger causality is presented that can be applied to panels with more time series observations than cross-sections. Inconsistency in these models with lagged dependent variables and fixed effects is avoided by differencing and pooling the data. The joint significance tests are also non-standard. The result is a set of homogeneous coefficients, which compare favorably to results from seemingly unrelated regressions under common conditions.
• AMALGAMATED DUPLICATION OF SOME SPECIAL NEAR-FIELDS (AD-SP-N-F)

In this paper I study and introducing myself some special type of near – fields amalgamated duplication near-field N ⋈ I over the rings and near-rings N. After in depth study of amalgamated duplication of some special rings achieved by D’Ama and Fontana. Let N be a commutative Noetherian near-filed and let I be an ideal of N. It is shown that if N is generically Cohen-Macaulay (resp. generically Gorenstein) and I is generically maximal Cohen-Macaulay (resp. generically canonical module), the N ⋈ I is generically Cohen-Macaulay (resp. generically Gorenstein). We also generically quasi – Gorenstein near-field and we investigate when N ⋈ I is generically quasi – Gorenstein near-field. In addition, it is shown that N ⋈ I is approximately Cohen-Macaulay if and only if N is approximately Cohen-Macaulay, provided some special conditions. Finally, it is shown that if N is approximately Gorenstein, then N ⋈ I is approximately Gorenstein.
Properties of Bovine Collagen as Influenced by High-Pressure Processing

The physical properties and structure of collagen treated with high-pressure technologies have not yet been investigated in detail. The main goal of this work was to determine whether this modern gentle technology significantly changes the properties of collagen. High pressure in the range of 0–400 MPa was used, and the rheological, mechanical, thermal, and structural properties of collagen were measured. The rheological properties measured in the area of linear viscoelasticity do not statistically significantly change due to the influence of pressure or the duration of pressure exposure. In addition, the mechanical properties measured by compression between two plates are not statistically significantly influenced by pressure value or pressure hold time. The thermal properties Ton and ∆H measured by differential calorimetry depend on pressure value and pressure hold time. Results from amino acids and FTIR analyses show that exposure of collagenous gels to high pressure (400 MPa), regardless of applied time (5 and 10 min), caused only minor changes in the primary and secondary structure and preserved collagenous polymeric integrity. SEM analysis did not show changes in collagen fibril ordering orientation over longer distances after applying 400 MPa of pressure for 10 min.
Prevalence of Supernumerary Teeth In Maxillary and Mandibular Anterior Region in A Group of Egyptian Children: A Retrospective Study

Introduction: One of the most common causes of impacted permanent anterior teeth is the presence of Supernumerary teeth (ST) which has an impact on developing teeth, and dental arches as well. Aim/ Objective: To evaluate the prevalence, distribution, characteristics, and complications of ST in maxillary and mandibular anterior region in a sample of Egyptian children.
Genetically Engineered Mice Unveil In Vivo Roles of the Mediator Complex

The Mediator complex is a multi-subunit protein complex which plays a significant role in the regulation of eukaryotic gene transcription. It provides a platform for the interaction of transcriptional factors and RNA polymerase II, thus coupling external and internal stimuli with transcriptional programs. Molecular mechanisms underlying Mediator functioning are intensively studied, although most often using simple models such as tumor cell lines and yeast. Transgenic mouse models are required to study the role of Mediator components in physiological processes, disease, and development. As constitutive knockouts of most of the Mediator protein coding genes are embryonically lethal, conditional knockouts and corresponding activator strains are needed for these studies. Recently, they have become more easily available with the development of modern genetic engineering techniques. Here, we review existing mouse models for studying the Mediator, and data obtained in corresponding experiments.
Parent-Integrated Interventions to Improve Language Development in Children Born Very Preterm

Neurodevelopmental challenges in children born very preterm are common and not improving. This study tested the feasibility of using Evidence-based Practice to Improve Quality (EPIQ), a proven quality improvement technique that incorporates scientific evidence to target improving language abilities in very preterm populations in 10 Canadian neonatal follow-up programs. Feasibility was defined as at least 70% of sites completing four intervention cycles and 75% of cycles meeting targeted aims. Systematic reviews were reviewed and performed, an online quality improvement educational tool was developed, multidisciplinary teams that included parents were created and trained, and sites provided virtual support to implement and audit locally at least four intervention cycles of approximately 6 months in duration. Eight of ten sites implemented at least four intervention cycles. Of the 48 cycles completed, audits showed 41 (85%) met their aim. Though COVID-19 was a barrier, parent involvement, champions, and institutional support facilitated success. EPIQ is a feasible quality improvement methodology to implement family-integrated evidence-informed interventions to support language interventions in neonatal follow-up programs. Further studies are required to identify potential benefits of service outcomes, patients, and families and to evaluate sustainability.
Mitochondrial Fission as a Therapeutic Target for Metabolic Diseases: Insights into Antioxidant Strategies

Mitochondrial fission is a crucial process in maintaining metabolic homeostasis in normal physiology and under conditions of stress. Its dysregulation has been associated with several metabolic diseases, including, but not limited to, obesity, type 2 diabetes (T2DM), and cardiovascular diseases. Reactive oxygen species (ROS) serve a vital role in the genesis of these conditions, and mitochondria are both the main sites of ROS production and the primary targets of ROS. In this review, we explore the physiological and pathological roles of mitochondrial fission, its regulation by dynamin-related protein 1 (Drp1), and the interplay between ROS and mitochondria in health and metabolic diseases. We also discuss the potential therapeutic strategies of targeting mitochondrial fission through antioxidant treatments for ROS-induced conditions, including the effects of lifestyle interventions, dietary supplements, and chemicals, such as mitochondrial division inhibitor-1 (Mdivi-1) and other mitochondrial fission inhibitors, as well as certain commonly used drugs for metabolic diseases. This review highlights the importance of understanding the role of mitochondrial fission in health and metabolic diseases, and the potential of targeting mitochondrial fission as a therapeutic approach to protecting against these conditions.
Differentiating Characteristics and Responses to Treatment of New-Onset Heart Failure With Preserved and Reduced Ejection Fraction in Ambulatory Patients

Background Differences in clinical presentation and therapy outcomes between heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF) have been reported but described mainly among hospitalized patients. Because the population of outpatients with heart failure (HF) is increasing, we sought to discriminate the clinical presentation and responses to medical therapy in ambulatory patients with new-onset HFpEF vs. HFrEF. Methods We retrospectively included all patients with new-onset HF treated at a single HF clinic in the past 4 years. Clinical data and electrocardiography (ECG) and echocardiography findings were recorded. Patients were followed up once weekly, and treatment response was evaluated according to symptoms resolution within 30 days. Univariate and multivariate regression analyses were performed. Results A total of 146 patients were diagnosed with new-onset HF: 68 with HFpEF and 78 with HFrEF. The patients with HFrEF were older than those with HFpEF (66.9 vs. 62 years, respectively, P = 0.008). Patients with HFrEF were more likely to have coronary artery disease, atrial fibrillation, or valvular heart disease than those with HFpEF (P < 0.05 for all). Patients with HFrEF rather than HFpEF were more likely to present with New York Heart Association class 3 - 4 dyspnea, orthopnea, paroxysmal nocturnal dyspnea or low cardiac output (P < 0.007 for all). Patients with HFpEF were more likely than those with HFpEF to have normal ECG at presentation (P < 0.001), and left bundle branch block (LBBB) was observed only in patients with HFrEF (P < 0.001). Resolution of symptoms within 30 days occurred in 75% of patients with HFpEF and 40% of patients with HFrEF (P < 0.001). Conclusions Ambulatory patients with new-onset HFrEF were older, and had higher incidence of structural heart disease, in comparison to those with new-onset HFpEF. Patients presenting with HFrEF had more severe functional symptoms than those with HFpEF. Patients with HFpEF were more likely than those with HFpEF to have normal ECG at the time of presentation, and LBBB was strongly associated with HFrEF. Outpatients with HFrEF rather than HFpEF were less likely to respond to treatment.