Miracle-dz/UniFAR-FTUs huggingface dataset:
Towards Efficient and Privacy-Preserving User-Defined Skyline Query Over Single Cloud

Skyline queries, especially those variants that allow users to define their own query criteria, are very promising and practical techniques in multi-criteria decision making applications. Meanwhile, the growing data volume drives the service providers to outsource their data to the cloud for reaping economic benefits. However, privacy concerns compel the outsourced data to be encrypted and require to perform the skyline queries over encrypted data. To achieve the privacy-preserving skyline queries, many schemes were proposed in the literature. However, those existing solutions cannot fully support the user-defined query criteria in skyline queries, and most of them employ a two-server model to support skyline queries over ciphertexts, which needs multi-round communications between the deployed two servers. In this article, we propose a privacy-preserving user-defined skyline query scheme in a single-server model, which eliminates extra communications. Specifically, we first formally define the user-defined skyline query. Then, based on the idea of converting order relations into computing the inner products of two multi-dimensional points, we design three predicate encryption schemes. Finally, we adopt these predicate encryption schemes to construct our proposed scheme. Detailed security analysis shows that these predicate encryption schemes are selectively secure, and the proposed user-defined skyline query scheme is privacy-preserving. In addition, extensive experiments are conducted, and the results show that our proposed scheme outperforms the alternative scheme by up to an order of magnitude in terms of computational costs when performing user-defined skyline queries.
G-Quadruplex Matters in Tissue-Specific Tumorigenesis by BRCA1 Deficiency

How and why distinct genetic alterations, such as BRCA1 mutation, promote tumorigenesis in certain tissues, but not others, remain an important issue in cancer research. The underlying mechanisms may reveal tissue-specific therapeutic vulnerabilities. Although the roles of BRCA1, such as DNA damage repair and stalled fork stabilization, obviously contribute to tumor suppression, these ubiquitously important functions cannot explain tissue-specific tumorigenesis by BRCA1 mutations. Recent advances in our understanding of the cancer genome and fundamental cellular processes on DNA, such as transcription and DNA replication, have provided new insights regarding BRCA1-associated tumorigenesis, suggesting that G-quadruplex (G4) plays a critical role. In this review, we summarize the importance of G4 structures in mutagenesis of the cancer genome and cell type-specific gene regulation, and discuss a recently revealed molecular mechanism of G4/base excision repair (BER)-mediated transcriptional activation. The latter adequately explains the correlation between the accumulation of unresolved transcriptional regulatory G4s and multi-level genomic alterations observed in BRCA1-associated tumors. In summary, tissue-specific tumorigenesis by BRCA1 deficiency can be explained by cell type-specific levels of transcriptional regulatory G4s and the role of BRCA1 in resolving it. This mechanism would provide an integrated understanding of the initiation and development of BRCA1-associated tumors.
Low Sperm Motility Is Determined by Abnormal Protein Modification during Epididymal Maturation

Purpose During epididymal sperm maturation, spermatozoa acquire progressive motility through dynamic protein modifications. However, the relationship between sequential protein modifications during epididymal sperm maturation and sperm motility and fertility has not yet been investigated. This study investigated whether sequential changes in fertility-related protein expression including that of enolase 1 (ENO1), ubiquinol-cytochrome c reductase core protein 1 and 2 (UQCRC1 and UQCRC2), and voltage-dependent anion channel 2 (VDAC2) in spermatozoa during epididymal maturation are related to bovine sperm motility. Moreover, we found that mitochondrial metabolism is closely related to fertility-related proteins. Therefore, we investigated how the sequential modification of mitochondrial proteins during epididymal maturation regulates sperm motility. Materials and Methods To determine the differential protein expression in caput and cauda epididymal spermatozoa from low and high motility bulls, western blot analysis was performed. Moreover, signaling pathways were identified to understand the mechanisms of regulation of sperm motility through the differential protein expression associated with fertility-related proteins. Results We found that ENO1 was substantially higher in the caput spermatozoa from low motility bulls than the caput and cauda spermatozoa from high motility bulls. However, ENO1 expression in low motility bull spermatozoa was downregulated to a level comparable to that in the high motility bull spermatozoa during epididymal maturation. Moreover, there was a lack of modification of mitochondrial proteins, including glutathione peroxidase 4 and NADH:Ubiquinone Oxidoreductase Core Subunit S8, in low motility bull spermatozoa during epididymal maturation, whereas active changes were detected in high motility bull spermatozoa. Conclusions Irregular modifications of mitochondrial proteins during epididymal sperm maturation may increase excessive ROS production and premature activation of spermatozoa during epididymal maturation. Consequently, spermatozoa may lose their motility by the earlier consumption of their energy source and may be damaged by ROS during epididymal maturation, resulting in a decline in sperm motility and bull fertility.
Cellulosic-Based Conductive Hydrogels for Electro-Active Tissues: A Review Summary

The use of hydrogel in tissue engineering is not entirely new. In the last six decades, researchers have used hydrogel to develop artificial organs and tissue for the diagnosis of real-life problems and research purposes. Trial and error dominated the first forty years of tissue generation. Nowadays, biomaterials research is constantly progressing in the direction of new materials with expanded capabilities to better meet the current needs. Knowing the biological phenomenon at the interaction among materials and the human body has promoted the development of smart bio-inert and bio-active polymeric materials or devices as a result of vigorous and consistent research. Hydrogels can be tailored to contain properties such as softness, porosity, adequate strength, biodegradability, and a suitable surface for adhesion; they are ideal for use as a scaffold to provide support for cellular attachment and control tissue shapes. Perhaps electrical conductivity in hydrogel polymers promotes the interaction of electrical signals among artificial neurons and simulates the physiological microenvironment of electro-active tissues. This paper presents a review of the current state-of-the-art related to the complete process of conductive hydrogel manufacturing for tissue engineering from cellulosic materials. The essential properties required by hydrogel for electro-active-tissue regeneration are explored after a short overview of hydrogel classification and manufacturing methods. To prepare hydrogel from cellulose, the base material, cellulose, is first synthesized from plant fibers or generated from bacteria, fungi, or animals. The natural chemistry of cellulose and its derivatives in the fabrication of hydrogels is briefly discussed. Thereafter, the current scenario and latest developments of cellulose-based conductive hydrogels for tissue engineering are reviewed with an illustration from the literature. Finally, the pro and cons of conductive hydrogels for tissue engineering are indicated.
Dietary Soluble Non-Starch Polysaccharide Level Influences Performance, Nutrient Utilisation and Disappearance of Non-Starch Polysaccharides in Broiler Chickens

Simple Summary Non-starch polysaccharides (NSP) constitute a major part of the dietary fibre component in plant-based feed ingredients, accounting for approximately 10% of the nutrients in a poultry diet. However, NSP are generally not considered during formulation of commercial broiler diets. The functions of dietary NSP in poultry diets, including both the soluble and insoluble fraction, has been extensively researched and discussed. The soluble fraction is of particular interest to poultry nutritionists and producers, as it increases digesta viscosity, affecting nutrient digestion and absorption and thus litter quality. Soluble NSP (sNSP) also provides fuel for beneficial microbiota species. The extent of impact of dietary sNSP level on broiler performance and nutrient utilisation is poorly understood. Consequently, in this study, broilers were fed commercial-type diets with varying sNSP levels, and the effects of the sNSP level on ileal and total tract nutrient digestibility and productive performance were evaluated. The results revealed that even a small variation in dietary sNSP content induces an impact in broilers, particularly in young birds. Thus, sNSP level and composition should be considered during formulation of commercial poultry diets. Abstract This study evaluated the effect of dietary soluble non-starch polysaccharides (sNSP) on performance and nutrient utilisation in broilers from d 0 to 35. Cobb 500 broilers (n = 480, 80 birds per treatment) were fed either wheat- or corn-soybean meal-based diets formulated to contain either a high, medium, or low sNSP content, in a 2 × 3 factorial arrangement, fed as Starter (d 0–14) and Grower (d 14–35). Birds fed the low sNSP level presented greater BWG at d 0–14 and lower feed intake at d 14–35 compared to birds fed the medium sNSP level (p < 0.005). At d 14, birds fed the high sNSP level presented greater ileal and total tract starch digestibility and total tract sNSP degradability and insoluble NSP degradability, compared to feeding the low sNSP level. At d 35, total tract DM and metabolisability of gross energy was greater in birds fed the medium sNSP level compared to those fed the high or low sNSP level (p < 0.005). Generally, bird performance and nutrient utilisation was greater in birds fed the corn-based diets compared to the wheat-based diets. These results illustrate that dietary sNSP level and composition influences bird performance and nutrient digestibility.
Mechanical Analysis and Design Optimization for Stud Connectors of Composite Girders in Second Jiaojiang Bridge during Construction

Separated two closed-sections were used in composite girders of main bridge of the second Jiaojiang bridge.In order to avoid the cantilever hoisting construction happening in typhoon season,a new construction method that is two-segment hoisting in a construction cycle step was adopted,which saved construction time greatly.The abrupt change of bending stiffness of the main girder near the wet concrete joint and local lifting weight increasing as two times as that of the origin plan induced the complex mechanical behavior of stud connectors in the composite girder near the wet concrete joint.Reasonable stud layout in designing was the crucial factors of this new construction method.The spatial model of a two-segment composite girder with hoisting construction method was simulated by ANSYS program in detail and the mechanical behavior of the stud connector near the wet concrete joint was calculated.Several structural plans were proposed and analyzed to optimize and improve the mechanical behavior of the connector near the wet concrete joint.The analysis results showed that the shear force of connectors decreased obviously and the connector safety was improved effectively by the optimized method.
Stratification for Risk Factors and Its Correlation to Outcome in Children with Malnutrition of Age 6 Months to 5 Years

Background: Wide range of illness is covered under malnutrition including under nutrition, specific nutrient deficiencies and over nutrition. There is heavy cost burden on Pakistani economy due to high prevalent condition. Children are affected in several ways and exposed to infectious diseases, psychosocial mal-development and cognitive deficiencies. Objectives: Objectives of this study are to determine the risk factors of malnutrition in children of age 6 months to 5 years and to determine the correlation between risk factors of malnutrition and outcome in children of age 6 months to 5 years. Methodology: A prospective observational study was conducted at Paediatric Medicine Department, PUMHS (Nawabshah). 138 patients were recruited using the non-probability consecutive sampling technique. Informed consent was taken from study participants before enrolment into the study. Children admitted to peadiatric medicine ward were explored for malnutrition risk factors. A pre-designed proforma was used for data collection. Data was analyzed using SPSS version 21. Results: Out of 138 children, 78 (56.5) were males and 60 (43.5) were females. Average age of patients was 27.49 ± 13.32. Using criteria of MUAC, 97 (70.28%) were severely malnourished and 41 (29.71%) were moderately malnourished. By criteria of weight-to-height z-score, 116 (84.05%) were severe malnourished and 22 (15.94%) were moderately malnourished. Among child factors, the highest prevalent risk factor was bottle and mixed feeding practice (122, 88.40%). Child related factors were significantly associated with patients’ outcome. Among parental risk factors, the highest prevalent risk factor was unemployment (96, 69.57%) fathers of patients were unemployed. Among environmental factors, the most prevalent risk factor was use of inappropriate water source (102, 73.91%). 31 (22.46%) children expired at the end of the study. Environmental factors were also found to be associated with patients’ outcome. Conclusion: Lack of breast feeding, unemployment and inappropriate source of water were most prevalent factors. Furthermore, illiteracy and incomplete vaccination status were also prevalent. Therefore, interventions are needed in order to overcome these problems. Parental education should be done and high authorities should make efforts to provide clean and safe water in rural area as well.
Pheromone Receptor Knock-Out Affects Pheromone Detection and Brain Structure in a Moth

Sex pheromone receptors are crucial in insects for mate finding and contribute to species premating isolation. Many pheromone receptors have been functionally characterized, especially in moths, but loss of function studies are rare. Notably, the potential role of pheromone receptors in the development of the macroglomeruli in the antennal lobe (the brain structures processing pheromone signals) is not known. Here, we used CRISPR-Cas9 to knock-out the receptor for the major component of the sex pheromone of the noctuid moth Spodoptera littoralis, and investigated the resulting effects on electrophysiological responses of peripheral pheromone-sensitive neurons and on the structure of the macroglomeruli. We show that the inactivation of the receptor specifically affected the responses of the corresponding antennal neurons did not impact the number of macroglomeruli in the antennal lobe but reduced the size of the macroglomerulus processing input from neurons tuned to the main pheromone component. We suggest that this mutant neuroanatomical phenotype results from a lack of neuronal activity due to the absence of the pheromone receptor and potentially reduced neural connectivity between peripheral and antennal lobe neurons. This is the first evidence of the role of a moth pheromone receptor in macroglomerulus development and extends our knowledge of the different functions odorant receptors can have in insect neurodevelopment.
Prevalence and Characteristics of Oral Squamous Cell Carcinoma in Fiji: A Retrospective Study

BACKGROUND: Oral squamous cell carcinoma (OSCC) is malignant epithelial neoplasm that affects the oral cavity. Despite the large number of studies on OSCC in the literature, details on the demographic profile of these lesions in different populations are limited, especially amongst the Fijian population, thus this study aimed to determine the prevalence and characteristics of OSCC cases diagnosed from 2011 to 2015 at the Colonial War Memorial Hospital (CWMH), Suva, Fiji Islands. MATERIALS & METHODS: A retrospective quantitative study was carried out at the CWMH Histology department looking at OSCC cases diagnosed from 2011–2015. All confirmed cases were included in the study and excluded cases were suspected cases that were pending diagnosis and children. An extraction sheet was used for data collection which was designed to meet the requirements of study finding. This data was entered in SPSS software and then analyzed using the simple analytical tool as bar graphs and tables. RESULTS: There were 74 OSCC cases diagnosed in the study period. The occurrence of OSCC cases over the 5-year period was fluctuant with the year 2013 recording the highest number of cases (24 cases, 32%). During the reported period, more men suffered (53 cases, 72%) from this condition with the tongue (40%) being the commonest oral cancer site followed by the lip and vermillion border (28%). Individuals in the 40 to 60 years’ age group (35 cases, 47.3%) were mostly affected with the I-taukei population (38 cases, 51.4%) recording the highest occurrence of OSCC. The results show that, the common occurrence is the tongue (40.5%) while the least presentation sight is Buccal mucosa/buccal sulcus area (8.1%). CONCLUSION: The study concluded that more men suffer from oral squamous cell carcinoma compared to woman and the ethnicity that was most affected was I-taukei population. More detailed record keeping and reporting of oral cancer is needed to help evaluate progress in controlling oral cancer in the Fiji Islands. This availability of geographic data would further assist the Ministry of Health of Fiji in data collection and planning of preventative activities
A Novel Approach to Increase Attention during Mirror Therapy among Stroke Patients: A Video-Based Behavioral Analysis

Stroke is a major cause of disability and an evident rehabilitation strategy is crucial. Mirror therapy (MT) is one of the popular rehabilitation methods that is known to be effective as the patients benefit from the mirror illusion. However, the patient’s attention to the mirror illusion during treatment is unclear. Therefore, the present study assesses the duration and frequency of the mirror gaze, distraction, and preparation of sixteen stroke patients during two MT methods using a behavioral coding software. During the 30 min treatment, the total mirror gaze duration during conventional bilateral MT (BMT) was 564.04 s, while it was 1482.45 s in unilateral MT using a screen (UMT). The total distracted time was 945.61 s in BMT, while it was only 162.03 s in UMT. The total preparatory duration was 290.35 s in BMT and 155.53 s in UMT. The total number of distracted bouts were 136.45 in BMT, while it was 73.38 in UMT. The total number of preparatory bouts were 18.42 in BMT and 9.56 in UMT. The average times of gaze duration per bout were 5.52 s in BMT and 21.81 s in UMT. The average times of distraction per bout were 9.22 s in BMT and 3.00 s in UMT. The total number of mirror gaze bouts and average time of preparation per bout did not present a statistical significance in the comparisons of the two methods. This study assesses two methods of MT using observational coding software to evaluate the duration and frequency of the mirror gaze during treatment. The results suggest that UMT may be an alternative option to provide MT for stroke patients to increase their attention towards the mirror.
Antenna/Propagation Domain Self-Interference Cancellation (SIC) for In-Band Full-Duplex Wireless Communication Systems

In-band full duplex (IBFD) is regarded as one of the most significant technologies for addressing the issue of spectrum scarcity in 5G and beyond systems. In the realization of practical IBFD systems, self-interference, i.e., the interference that the transmitter causes to the collocated receiver, poses a major challenge to antenna designers; it is a prerequisite for applying other self-interference cancellation (SIC) techniques in the analog and digital domains. In this paper, a comprehensive survey on SIC techniques in the antenna/propagation (AP) domain is provided and the pros and cons of each technique are studied. Opportunities and challenges of employing IBFD antennas in future wireless communications networks are discussed.
The Rethoric of Gender Mainstreaming During Covid-19 Pandemic in North Sumatra

This study aims at exploring the challenges to the implementation of gender mainstreaming in managing Covid-19 crisis in North Sumatra. It focuses on indicators in aspects of access, participation, control over resources and decision making, and the benefits of policies and programs for managing Covid-19 pandemic. This study is based on feminist qualitative research design. Data collection techniques included in-depth interviews, case studies, focused group discussions (FGD) and observation. Research informants consists of the local government and the Covid-19 Task Force, the Women and Children Empowerment Agency, Social Service, NGOs and women working in Medan and Siantar city. The findings reveal the handling of Covid-19 in North Sumatra ignores gender issues as evident by the absence of gender-based data in various Covid-19 handling programs, and the limited participation of women in crisis management related institutions. This study suggests the urgency of enhancing local government awareness, capacity and commitment in integrating gender in managing crisis as the key to the success of effective and equitable disaster management.