Miracle-dz/UniFAR-FTUs huggingface dataset:
Magnetostriction and magnetization of tension annealed rods of Fe82Ga18

Slow and fast growth textured polycrystalline rods of Fe82Ga18 have been annealed at 300 and 600 °C under 50 MPa of tensile stress for 20 min. The rods showed a built-in positive internal stress of ∼20 MPa (300 °C annealing) to ∼30 MPa (600 °C annealing), corresponding to an induced uniaxial anisotropy energy from −4 to −5.5 kJ/m3. Slow growth samples showed better alignment of moments along the rod axis due to better grain alignment. After a 600 °C annealing without applied stress, the sample properties showed no remnants of any prior stress annealing treatments and were better than the as-received unannealed samples.
Endocrinology and Diabetes Case Production of Sheep Embryos In Vitro

In-Vitro Maturation (IVM) and In-Vitro Fertilization (IVF) are the potential methods for producing the early embryos in large numbers. Recently many producers have introduced IVF into their reproductive programs. Successful in vitro production of embryo depends upon the good oocyte maturation and correct sperm capacitation. Ovaries were collected from non-pregnant slaughtered sheep from a local slaughterhouse in normal saline. Ovaries having visible follicle and granular homogenous ooplasm were selected and cultured in maturation medium at 38.5 º C, 5% CO 2 and 95% humidity for 22-24 hr. The degree of cumulus cell expansion was determined after 22-24 hr of IVM and oocyte with expanded cumulus cell mass to at least 2 diameters away from the zona pellucida were considered as cumulus expanded. The matured oocytes were inseminated with 1 to 2 million spermatozoa/mL in Brackett and Oliphant medium and the embryos were then cultured in CO 2 incubator at 38.5 ° C, 5% CO 2 and 95% humidity and the cleavage was checked after 42-48 hr post insemination. The embryos were then further cultured for 6-7 days in order to produce a complete developmental series from the 2 cell to blastula stage of embryonic development. Our results showed that the percentage of maturation was 81.81±1.10, cleavage rate was 66.03±1.33, 8-16 cells was 43.44±0.62, Morula was 20.01±0.29, and Blastula was 8.59±0.56. The maturation rate was significantly (P<0.05) higher in May as compared to January, February, March and April. The percentage of 8-16 cell stage was also significantly higher in May as compared to those during February. It is concluded that the cleavage rate was good with Brackett and Oliphant fertilization media and TCM 199 as culture media in sheep with high blastula percentage during January. developmentally genes in
Enhancing H 2 O 2 Tolerance and Separation Performance through the Modification of the Polyamide Layer of a Thin-Film Composite Nanofiltration Membrane by Using Graphene

: Through interfacial polymerization (IP), a polyamide (PA) layer was synthesized on the top of a commercialized polysulfone substrate to form a thin-film composite (TFC) nanofiltration membrane. Graphene oxide (GO) was dosed during the IP process to modify the NF membrane, termed TFC-GO, to enhance oxidant resistance and membrane performance. TFC-GO exhibited increased surface hydrophilicity, water permeability, salt rejection, removal efficiency of pharmaceutical and personal care products (PPCPs), and H 2 O 2 resistance compared with TFC. When H 2 O 2 exposure was 0–96000 ppm-h, the surfaces of the TFC and TFC-GO membranes were damaged, and swelling was observed using scanning electron microscopy. However, the permeate flux of TFC-GO remained stable, with significantly higher NaCl, MgSO 4 , and PPCP rejection with increasing H 2 O 2 exposure intensity than TFC, which exhibited a 3.5-fold flux increase with an approximate 50% decrease in salt and PPCP rejection. GO incorporated into a PA layer could react with oxidants to mitigate membrane surface damage and increase the negative charge on the membrane surface, resulting in the enhancement of the electrostatic repulsion of negatively charged PPCPs. This hypothesis was confirmed by the significant decrease in PPCP adsorption onto the surface of TFC-GO compared with TFC. Therefore, TFC-GO membranes exhibited superior water permeability, salt rejection, and PPCP rejection and satisfactory resistance to H 2 O 2 , indicating its great potential for practical applications.
Determining flaky tests from test failures

Automated regression testing is widely used in modern software development. Whenever a developer pushes some changes to a repository, tests are run to check whether the changes broke some functionality. When previously passing tests fail, the most recent changes are typically suspected, and developers invest time and effort to debug those changes. Unfortunately, new test failures may not be due to the latest changes but due to non-deterministic tests, popularly called flaky tests, that can pass or fail even without changes to the code under test. Many projects have such flaky tests, which can cause developers to lose confidence in test results. Therefore, developers need techniques that can help them determine whether a test failure is due to their latest changes and warrants their debugging, or whether it is due to a flaky test that should be potentially debugged by someone else. The most widely used technique for determining whether a test failure is due to a flaky test is to rerun the failing test multiple times immediately after it fails: if some rerun does pass, the test is definitely flaky, but if all reruns still fail, the status is unknown. This thesis proposes three improvements to this basic technique: (1) postponing the reruns, (2) rerunning in a new runtime environment (e.g., a new JVM for Java tests), and (3) intersecting the test coverage with the latest changes. The thesis evaluates the cost of (1) and (2) and evaluates the applicability of (3) on 15 projects with a total of 2715 test classes, 10 of which contain previously known flaky tests. The results show that the proposed improvements are highly applicable and would be able to determine that more failures are due to flaky tests for the same or somewhat higher cost as rerunning failing tests immediately after failure.
Case Report Diffuse Subcutaneous Emphysema and Pneumomediastinum Secondary to a Minor Blunt Chest Trauma

Full medical evaluation is paramount for all trauma patients. Minor traumas are often overlooked, as they are thought to bear low injury potential. In this case report, we describe the case of a 48-year-old man presenting to our Emergency Department with mild to moderate right-sided shoulder and scapular pain following a fall from his own height ten days previously. Clinical and paraclinical investigations (CT) revealed diffuse right shoulder pain, with crepitations on palpation of the neck, right shoulder, and right lateral chest wall. Computed tomography (CT) demonstrated right-sided costal fractures (ribs 7 to 9), with diffuse subcutaneous emphysema and pneumomediastinum due to laceration of the visceral and parietal pleura and the adjacent lung parenchyma. In addition, a small ipsilateral pneumothorax was found. Surprisingly, the clinical status was only minimally affected by mild to moderate pain and minor functional impairment.
Review Intake and metabolism of n-3 and n-6 PUFA: Nutritional implications for cardiometabolic diseases

1 Department of Molecular Epidemiology, German Institute of Human Nutrition PotsdamRehbruecke, Nuthetal, Germany 2 German Center for Diabetes Research (DZD), Neuherberg, Germany 3 Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany 4 Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, United Kingdom 5 Clinical Pathology Department, Faculty of Medicine, Alexandria University, Egypt 6 Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden
Epidermal Growth Factor Receptor Fate Is Controlled by Hrs Tyrosine Phosphorylation Sites That Regulate Hrs Degradation (cid:1)

Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is an endosomal protein essential for the efﬁcient sorting of activated growth factor receptors into the lysosomal degradation pathway. Hrs undergoes ligand-induced tyrosine phosphorylation on residues Y329 and Y334 downstream of epidermal growth factor receptor (EGFR) activation. It has been difﬁcult to investigate the functional roles of phosphoHrs, as only a small proportion of the cellular Hrs pool is detectably phosphorylated. Using an HEK 293 model system, we found that ectopic expression of the protein Cbl enhances Hrs ubiquitination and increases Hrs phosphorylation following cell stimulation with EGF. We exploited Cbl’s expansion of the phosphoHrs pool to determine whether Hrs tyrosine phosphorylation controls EGFR fate. In structure-function studies of Cbl and EGFR mutants, the level of Hrs phosphorylation and rapidity of apparent Hrs dephosphorylation correlated directly with EGFR degradation. Differential expression of wild-type versus Y329,334F mutant Hrs in Hrs-depleted cells revealed that one or both tyrosines regulate ligand-dependent Hrs
Efficacy of Pulmonary Rehabilitation vs . High Frequency Neuromuscular Electrical Stimulation Emphasizing Lower Limb Muscle Training in Severe COPD Patients

Background: COPD is the most common chronic lung diseases and are major causes of lung related death and disability. Exercise training a core component of PR improves exercise capacity of patients with COPD although there are irreversible abnormalities in lung function. HF-NMES was successfully used as a localized training modality in severely disabled patients. Objective: To evaluate the effectiveness of PR vs . HF-NMES emphasizing lower limb muscle training to improve the efficiency of 5 STS time and 6MWD in severe COPD patients. Methods: The study population consisted of 45 patients diagnosed as severe COPD based on GOLD guidelines. 6 MWT distance and other parameters were measured at baseline and at 4 th week, 8 th week and 12 th weeks of training programme. One way ANOVA was used to evaluate the association between 6MWD, 5STS time and CCQ score. Results: Lower Limb Muscle Training Modalities (HF-NMES) improved exercise performance significantly, while it is known that the load on the cardio-respiratory system is rather low. Mean improvements in six minute walk distance exceeded in the HF-NMES group. Conclusion: There is significant improvement in 5 STS time and 6 MWT distance following 12 weeks of lower limb muscle training in PR program and in HF-NMES for severe COPD patients. role of
IN VITRO ANTIPLASMODIAL ACTIVITY OF METHANOLIC ROOT EXTRACT OF BOERHAAVIA DIFFUSA ON CHLOROQUINE SENSITIVE PLASMODIUM FALCIPARUM

This study evaluated the antimalarial effect of B. diffusa root extract on chloroquine sensitive P. falciparum . This was with a view to providing additional scientific information on its use as an antimalarial agent. The crude methanolic root extract of the plant was tested for its in vitro anti-plasmodial activity against Plasmodium falciparum (chloroquine-sensitive strain). In this study, 100 µl culture media were dispensed into a 96-well microtitre plate, leaving the ‘A’ series. Then, 100 µl of the test extract was pipetted into well ‘A’ and double fold serial dilutions were made down to well ‘H’. The last series 12 wells served as control. Twenty five (25) µl of infected red cells was separately added into all the wells in the test plates and mixed by swirling with the tips to ensure homogeneity and incubated at 37 0 C in a candle jar and assessed for parasite growth after 27 h of incubation. The results of the in vitro assay showed that the methanolic extract of B. diffusa possessed weak antimalarial activity against P falciparum with IC 50 of 55.35 µg/ml when compared with the standard antimalarial drug chloroquine whose IC 50 was 0.5209 µg/ml. The antiplasmodial activity of the roots of the plant supports local claims on its efficacy in the treatment of malaria infection.
The Endomembrane System of Giardia intestinalis The Endomembrane System of Giardiaintestinalis

Giardia intestinalis is a protozoan that colonizes the small intestine of virtually all mam- mals, adhering to the mucosal epithelial cells. It is a cosmopolitan parasite and agent of giardiasis, which can lead to human diarrheal diseases. The Giardia life cycle presents two forms — the trophozoite and the cyst — which are responsible for infection and transmission, respectively. This cell has been considered an excellent model for evolutionary studies, even though there are controversial hypotheses as to whether this parasite is an early eukaryote or not. G. intestinalis has a unique and very basic endomembrane system. The trophozoite gathers a very small pack of membrane-bounded structures: nuclei, endoplasmic reticulum (ER), peripheral vesicles (PV) and mitosomes. These organelles are involved in many functions from regulatory aspects in gene expression as well as membrane traffic events. Two functional nuclei are observed in the parasite; they are always located symmetrically in the anterior region of the trophozoite. The ER and PV commonly share and accumulate functions in the secretory pathway, they are responsible for endocytosis and digestion processes. The mitosome is a mitochondria-related organelle that does not produce ATP and lacks several mitochondrial character- istics. During the parasite differentiation into cyst, different types of vesicles appear into the cell body: the encystation specific vesicles (ESVs) and the encystation carbohydrate- positive vesicles (ECVs). These vesicles work together to form the parasite ’ s cyst wall in order to ensure that the cell reaches the cyst stage. Interestingly, Giardia does not present a morphologically recognized Golgi apparatus. It has been claimed that during the encystation process, the ESVs could represent a Golgi-like structure, because this organ- elle presents some characteristics of that high eukaryotic Golgi apparatus. In this book chapter, we highlight the G. intestinalis endomembrane system, emphasizing their mor- phology, proteins involved in its organization as well as their functional role.
A Study on the Advanced Logic State Diagnosis of Logic Lab-unit for Digital Education

Background/Objectives : In this paper, a method to distinguish +3.3 V logic state from the 4-level logic state (i.e., 0 V , open, +5 V and high-voltage) diagnosis circuit of the logic lab-unit was proposed. Methods/Statistical analysis : It is theoretically verified that the conventional logic state diagnosis circuit is difficult to distinguish the +3.3 V logic state; the proposed method can distinguish logic state clearly. Findings : In order to verify the performance of the proposed method, the 6-chanel diagnosis circuit was set up to measure the output for each logic state. In the conventional method, it is possible to distinguish between open state and +3.3 V logic state within the 0.43 V under the ideal condition. However, it cannot distinguish them under the noisy condition. Improvements/Applications : On the other hand, the proposed method is measured 1.96 V (i.e., increased by 455%) between the open state and the +3.3 V logic state without affecting other states. In addition, the robustness of the measurement was verified in a noise environment. Since the proposed method is used by the microcontroller and analog multiplexer, it can be implemented with only one tri-state buffer or one transistor. Therefore, the proposed method is economically advantageous, as well.
The Synchrotron Jet from the H2O Maser Source in W3(OH)

We report results of sensitive Very Large Array observations of the 8.4 GHz continuum emission associated with the TW object, a luminous young star located at the center of expansion of the H2O masers in the W3(OH) region. The source has a radio spectral index of -0.6 and exhibits a sinuous double-sided morphology; these are characteristics of a synchrotron jet. No significant changes are seen in the jet morphology in observations separated by 510 days. The inhomogeneous synchrotron model proposed by Reid et al., which is based on the spectrum and size variation with observing frequency, correctly predicts the flux density profile of the radio emission. Secondary radio continuum features located at the extrema of the H2O maser distribution may mark the location of strong shocks and deeply embedded Herbig-Haro objects or additional young stellar objects in the W3(OH) cluster. Several more compact sources are identified in the region, some of which are highly variable. These may be low-mass pre-main-sequence stars with magnetic activity.
CMAR_A_245426 6695..6706

Di Wang* Xia Zhang* Yajie Gao Xiaonan Cui Yanqin Yang Weifeng Mao Minghuan Li Bin Zhang Jinming Yu 1Department of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, People’s Republic of China; 2Department of Oncology, The Fifth People’s Hospital of Dalian, Dalian, People’s Republic of China; 3Department of Radiation Oncology, The Second Affiliated Hospital of Dalian Medical University, Dalian, People’s Republic of China; 4The School of Basic Medical Sciences, Dalian Medical University, Dalian, People’s Republic of China; 5Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, People’s Republic of China
68 Ga-PSMA PET/CT for primary NM staging of high-risk prostate cancer

With the largest high-risk prostate cancer (PCa) cohort to date undergoing 68 Ga-prostate-specific membrane antigen (PSMA) PET/CT primary staging, we aimed to 1) characterize the metastatic spread of PCa in relation to tumor 68 Ga-PSMA-uptake and the D’Amico classification, and 2) compare 68 Ga-PSMA PET/CT findings with radical prostatectomy (RP) with pelvic lymph node dissection (PLND) histopathology. Methods A total of 691 consecutive newly diagnosed, biopsy-proven, treatment-naïve, D’Amico high-risk PCa patients primary staged by 68 Ga-PSMA PET/CT were included. PSMA maximum standardized uptake value (SUV max ) and metastatic findings were compared to PSA level, International Society of Urologic Pathology (ISUP) grade, and clinical stage as traditional risk stratification parameters. Moreover, 68 Ga-PSMA PET/CT findings were compared with histology in RP patients undergoing PLND. Undetected lymph node metastases (LNMs) underwent immunohistochemical PSMA staining.
Has U.S. Monetary Policy Tracked the Eﬃcient Interest Rate? (cid:73)

Interest rate decisions by central banks are universally discussed in terms of Taylor rules, which describe policy rates as responding to inﬂation and some measure of the output gap. We show that an alternative speciﬁcation of monetary policy, in which the interest rate tracks the Wicksellian eﬃcient rate of return as the primary indicator of real activity, ﬁts the U.S. data better than otherwise identical Taylor rules. This result holds for a variety of speciﬁcations of the other ingredients of the policy rule, including the output gap, and of private agents’ behavior.
Research of multi-point adaptive control strategy based on electromagnetic active vibration absorber

In order to improve the signal natural frequency of dynamic vibration absorber and eliminate the influence of nonlinear output force to the adaptive vibration absorption system. A new type of electromagnetic active vibration absorber is designed in this article. The internal magnetic circuit structure is changed through the electromagnet placed on the upper and lower, produce the electromagnetic force in two directions. Reaction force of upper mass is used to eliminate the target vibration. The effective frequency range of the vibration absorption increases, output force is basically linear. Aimed at multiple-point adaptive control strategy, a distributed multi-channel adaptive control algorithm is proposed, in which coupling between channels can be compensated on each control loop. Influence of secondary path on active control is analyzed, put forward the improved least mean square algorithm to identify the secondary. Active vibration control experiment platform is structured to verify the output force of absorber, and engineering application of the distributed multi-channel adaptive control algorithm. The results show that the distributed multi-channel adaptive control algorithm system has about 15 dB noise reduction, effect is obvious; new type of electromagnetic active vibration absorber is not limited to the natural frequency, output force can adaptive keep pace with the excitation frequency.
Effect of Food and Dosing Regimen on Safety and Efﬁcacy of Proton Pump Inhibitors Therapy—A Literature Review

: Proton pump inhibitors (PPIs) are the ﬁrst-choice drugs used to prevent and treat acid-related diseases. However, a lack of satisfactory response to the standard PPI dose (“PPI failure”) is often reported, especially in patients with gastroesophageal reﬂux disease. Poor compliance seems to be one of the main causes of PPI failure; hence, it is crucial to gain knowledge on how to properly administer PPIs. In this review, we aimed to evaluate the effect of food, beverages, and dosing regimen on pharmacokinetics and pharmacodynamics of PPIs and to frame recommendations for healthcare professionals to improve both patient’s counseling and compliance to treatment with PPIs. A total of 201 papers were identiﬁed following a literature search. After full-text evaluation, 64 studies were included in the review. Co-administration of PPIs with a meal may affect both their bioavailability and effectiveness; however, the inﬂuence of food depends on the type of drug and its formulation. Except for pantoprazole, PPIs can be administered in the morning or evening; however, morning intake generally provides better daytime control of gastric acidity. In most cases, the choice of the proper schedule of administration should be based on the patient’s symptoms and individual dosing preferences.
Edinburgh Research Explorer Performance-based financing in the context of selective free health-care

Performance-based financing (PBF) is an increasingly adopted strategy in low and middle-income countries. PBF pilot projects started in Burundi in 2006, at the same time when a national policy removed user fees for pregnant woman and children below 5 years. PBF was gradually extended to the 17 provinces of 15 the country. This rollout and data from the national health information system are exploited to assess the impact of PBF on the use of health-care services. Despite the limited quality of the data and the restricted size of the sample, an effect of PBF is found on the number of anti-tetanus vaccination of pregnant women (20.3 percentage points in target population). Non-robust effects are 20 also found on institutional deliveries and prenatal consultations. Changes in outpatient visits, postnatal visits and children vaccinations are not correlated with PBF. It is also found that more qualified nurses headed to PBF-supported provinces. Health facility-level figures from PBF-supported provinces show that most indicators but those on preventive care are growing through time. The dataset does not include indicators of the quality of care and does not allow to assess whether the impact of PBF is resource-driven or due to the incentive mechanism. The results are largely consistent with other impact evaluations conducted in Burundi and Rwanda. The fact that the impact of PBF is mostly visible on services that became free suggests an important interaction effect between the two strategies. A possible explanation is that the removal of user fees increases accessibility to health care and acts on the demand side while PBF gives medical staffs incentives for improving the provision of services. More empirical research is needed to understand the sustainability of (the incentive mechanism) PBF and the interaction between PBF and other health policies.