Miracle-dz/UniFAR-FTUs huggingface dataset:
Mandibular Rekonstru ksiyonlu Dişsiz Hastanın Sabit Hibrit Protezle Rehabilitasyonu: Olgu Sunumu Rehabilitation with Fixed Hybrid Restoration of an Edentulous Patient with Mandibular Reconstruction: A Case Report

karsinomun sol mandibular bölgede nüksü sebebiyle ortaya çıkan lezyonun cerrahi rezeksiyonu nedeniyle oluşan mandibular segmental defektin, serbest fibula flebi ile rekonstrüksiyonunu takiben implant-destekli hibrit protezle rehabilitasyonu anlatılmıştır. Parsiyel glossektomi ve mandibular rekonstrüksiyon Abstract: In this case report, the restoration of a segmental mandibular defect which occurred after the resection of a recurrent squamous cell carcinoma lesion with implant-supported hybrid prosthesis after reconstructed with free fibular flap was described. A 48-year-old male patient with partial glossectomy and mandibular reconstruction was referred to clinic due to maxillary and mandibular partial-edentulism. Clinical and radiological examinations revealed teeth with decreased bone support because of chronic-periodontitis and maxillary impacted canine. After extraction of impacted canine and other teeth, a wax-up try-in was performed to determine final teeth position and vertical dimension. Due to significant vertical tissue loss, hybrid-prostheses were planned. Four implants were inserted to each jaw. After osseointegration, open-tray impressions were taken, metal-frameworks were fabricated, and their passive fit were checked clinically. Centric relation, vertical dimension, phonetic and aesthetic of tooth setting were verified intraorally. After occlusal adjustments, the final prostheses were delivered to patient and screw holes were covered. The patient was satisfied with stability and esthetics of his prostheses and did not have any problems regarding prostheses during 6 months of service. The standard treatment approach for oral cancers is the surgical resection of pathological tissues with a certain sum of peripheral healthy tissue and reconstruction of hard and soft tissue defects secondary to the excision using different grafts. However, due to inadequate tissue support after reconstruction, conventional prosthetic restorations cannot have sufficient retention and function. Therefore, implant-supported hybrid prostheses represent good alternative for edentulous jaws with significant hard and soft tissue loss.
ATMOSPHERIC GAS ABSORPTION KNOWLEDGE IN THE SUBMILLIMETER

What: Members of the atmospheric and astronomical science communities met to review the current state of the art of the submillimeter spectral region. Knowledge of gas spectroscopy is still questionable at these frequencies but is important to fully exploit upcoming meteorological satellite measurements. When: 6–7 December 2018 Where: Darmstadt, Germany ATMOSPHERIC GAS ABSORPTION KNOWLEDGE IN THE SUBMILLIMETER Modeling, Field Measurements, and Uncertainty Quantification
hGH Transgenic Rats Expressing Severe Obesi of Treatment with hGH in a Pulsatile Manner ty and Effect

GB affects not only body growth but also carbohydrate and lipid metabolism [1]. Though the majority of the effects are believed to be brought about by enhancing the production of insulin-like growth f actor-I (IGF-I) in hepatic cells [2], some direct effects of GH on adipose tissue are also proposed [3]. Various experimental observations indicate that GH has both insulin-like and antiinsulin-like effects [1], but no simple and straightforward explanations of the GH action on carbohydrate and lipid metabolism are yet available. The significance of pulsatile and sexually differentiated secretory patterns of GH observed in mature animals has not been well analyzed [4], but these secretory patterns of GH appear to be important for regulating growth and metabolic function in the liver and adipose tissue [4, 5]. We previously produced hGH transgenic rats expressing relatively low circulating levels of hGH constantly [6]. In these transgenic rats, pulsatile secretory no pattern in either transgene-derived hGH or endogenous rGH could be detected [6]. One of the most striking phenotypes in these transgenic rats is severe obesity with hyper-insulinemia, -glycemia and hyperlipidemia . In this study, to study the significance of GH pulsatility, these trans-
Self-aligned dual-beam optical laser trap using photorefractive phase conjugation

We report what is to our knowledge the ﬁrst experimental demonstration and theoretical analysis of an optical laser trap that uses a pair of mutually phase-conjugate beams. A primary trapping beam derived from an argon laser (514.5 nm) together with its counterpropagating phase-conjugate beam creates a self-aligned dual- beam laser trap that provides stable three-dimensional conﬁnement for micrometer-sized dielectric particles. The transverse trapping efﬁciency, experimentally measured for low-numerical-aperture (N.A. 0.40 – 0.85) ob- jective lenses, is found to be comparable with that produced by a single-beam gradient force trap. A theoretical analysis, which compares the performance of the self-aligned dual-beam trap against that of single-beam gradient force and conventional counterpropagating dual-beam laser traps, shows that phase-conjugate trapping provides a slight improvement in axial trapping efﬁciency over the other trapping geometries. The ad- vantages of combining laser trapping with photorefractive optical phase conjugation for simultaneous sample micromanipulation and optical image processing are discussed. high-ﬁdelity phase-conjugate beam with a reﬂectivity of nearly 400% is realized. Experimental results indicate that the transverse trapping efﬁciency for 2.8- (cid:109) m-diameter microspheres in the two-beam phase-conjugate trap is comparable with that of a single-beam (gradient force) trap. Theoretical calculations using a ray optics model show that the two-beam phase-conjugate trap of-fers a slight improvement in axial trapping efﬁciency over that of a single-beam trap. The performance of a phase-conjugate trap is compared with that of a conventional counterpropagating dual-beam trap. Finally, the advan-tages and limitations of each conﬁguration, as well as the applications of phase-conjugate trapping to biology and other ﬁelds, are discussed.
Kinetics of CD4 1 T cell repopulation of lymphoid tissues after treatment of HIV-1 infection

Potent combinations of antiretroviral drugs diminish the turnover of CD4 1 T lymphocytes productively infected with HIV-1 and reduce the large pool of virions deposited in lymphoid tissue (LT). To determine to what extent suppression of viral replication and reduction in viral antigens in LT might lead correspondingly to repopulation of the immune system, we characterized CD4 1 T lymphocyte populations in LT in which we previously had quantitated viral load and turnover of infected cells before and after treatment. We directly measured by quantitative image analysis changes in
Detection of Helicobacter pylori IgG in diabetic patients and non-diabetic

Diabetes mellitus is one of the important causes of dyspepsia. The incidence of H. pylori is increased in diabetes mellitus. A total of ninety two (92) blood samples which include sixty two (62) samples for diabetic patient and thirty (30) samples non-diabetic as a control from November 2012 – March 2013 in private laborotary (Ibn- Alnafes) in Basra city. All samples were subjected to assessment of fasting blood sugar (FBS) level and detection of H. pylori antibodies ( H. pylori IgG) # by enzyme linked immunoabsorbent assay (ELIZA). The highest frequency of H.pylori was in diabetic patients 54/62(87%), while non diabetic patients (as control), was 3/30(10). Statistically the differences were significant (P < 0.05) among diabetic and non-diabetic patients with H. pylori . For the diabetic patients, of the total 37/62(60%) males, 32/37(86%) showed positive test for H. pylori IgG, while 22/25(88%) out of 25/62( 40 %) females, showed positive test of for H. pylori IgG, but the difference was statistically non significant (P > 0.05). For non diabetic group, of the total 18/30(60 %) males, 2/18(11%) showed positive test for H. pylori , and of the total 12/30( 40%) females, 1/12(8%) showed positive test for H.pylori IgG but the differences was statistically non significant (P > 0.05) Age of patients and control range from 20-80 years, for diabetic and non-diabetic
A Study on Westerly Troughs near Japan ( II )

The condition of upper atmosphere is investigated with relation to cyclones. The strongly deepening cyclones are associated with the typical westerly troughs which have a characteristic structure. On the other hand, cyclones can hardly develop in some period. The northward displacement of cyclones is remarkable in front of a typical westerly trough and is related to the distribution of westerly wind velocity.
ANAEROBIC MECHANISMS FOR THE DEGRADATION OF CELLULOSE

The state-of-the-art of anaerobic fermentation processes for the conversion of cellulosic waste materials to chemicals and fuels has been reviewed. The fermentation products reported from cellulose degradation generally included hydrogen, carbon dioxide, short-chain volatile acids, dicarboxylic acids, and ethanol. The various fermentations have generally been performed only at bench-scale. Most of the work has been done as either part of ruminant nutrition studies, or has been performed as research in microbiology. Little emphasis has been given to the types of kinetic and strain selection studies which would be useful as a basis for the design of large-scale or pilot-scale process equipment. The dollar values of products which could be produced from various anaerobic fermentations of cellulose ranged up to two thousand dollars per metric ton of substrate fermented. Further research to provide a basis for engineering development is recommended. action by these three Pseudomonas
Re‐evaluation of the Optimal Operating Conditions for the Primary End of an Integrated Steel Plant using Multi‐objective Genetic Algorithms and Nash Equilibrium

Some existing work on optimizing the operational cost of the primary end of an integrated steel plant containing two blast furnaces utilizing both pellets and sinters, an electric furnace and a basic oxygen furnace was further advanced using a multi‐objective genetic algorithm, along with a Nash equilibrium analysis. The new formulation was able to improve the earlier results very significantly, suggesting the efficacy of the multi‐objective approach over the more conventional single objective genetic algorithms.
Systematic Review of Available CAR-T Cell Trials around the World

Simple Summary CAR-T cells are genetically modified T cells that are reprogrammed to specifically eliminate cancer cells. Due to its clinical success to treat certain hematological malignancies, novel approaches to improve CAR-T cell-based therapies are being explored. This systematic review gives a worldwide overview of clinical trials evaluating new CAR-T cell therapies against different types of cancers, detailing the latest trends in CAR-T cell development. Abstract In this systematic review, we foresee what could be the approved scenario in the next few years for CAR-T cell therapies directed against hematological and solid tumor malignancies. China and the USA are the leading regions in numbers of clinical studies involving CAR-T. Hematological antigens CD19 and BCMA are the most targeted, followed by mesothelin, GPC3, CEA, MUC1, HER2, and EGFR for solid tumors. Most CAR constructs are second-generation, although third and fourth generations are being largely explored. Moreover, the benefit of combining CAR-T treatment with immune checkpoint inhibitors and other drugs is also being assessed. Data regarding product formulation and administration, such as cell phenotype, transfection technique, and cell dosage, are scarce and could not be retrieved. Better tracking of trials’ status and results on the ClinicalTrials.gov database should aid in a more concise and general view of the ongoing clinical trials involving CAR-T cell therapy.
Review on the application of green and environmentally benign biowaste and natural substances in the synthesis of lithium‐ion batteries

Environmental pollution and global warming have propelled the research activities toward the substitution of toxic materials with environmentally acceptable components in various spheres. Lithium‐ion battery (LIB) is exorbitantly used in different electronic devices in the present era and thus generates huge toxic electronic waste, which has become a global concern. Different approaches have been put forward to replace the commonly used materials for the fabrication of LIBs with processed biomass. This review discusses the significance and application of different biomass for fabricating electrodes and binders for LIBs. The electrochemical properties of the developed LIBs have also been discussed in detail. In addition, the required improvements have been put forth, so that biomass can be extensively used in future LIB to reduce the amount of generated toxic electronic wastes.
Pulmonary Pleomorphic Carcinoma Harboring EGFR Mutation Successfully Treated with Osimertinib: A Case Report

Pulmonary pleomorphic carcinoma (PPC) is well-known for its aggressive nature that is usually resistant to platinum-based chemotherapy. On the other hand, the efficacy of an immune checkpoint inhibitor-based regimen in PPC has been elucidated. PPCs harboring epidermal growth factor receptor (EGFR) mutations are extremely rare, and the efficacy of EGFR-tyrosine kinase inhibitors in PPC is limited compared to their efficacy in EGFR-mutated adenocarcinoma. A 43-year-old female patient presenting with a lung mass with multiple brain metastases, carcinomatous pericarditis, and multiple bone metastases was referred to our department. Transbronchial biopsy confirmed the diagnosis of PPC harboring an EGFR mutation with exon 19 deletion. Subsequently, she was treated with osimertinib, a third-generation EGFR-tyrosine kinase inhibitor, which resulted in partial response with shrinkage of the primary lesion and brain metastases. This partial response remained durable for 11 months with an ongoing regimen. The current case suggests that osimertinib would show promising effects as a first-line treatment for PPCs harboring EGFR mutations, as well as a reasonable sequence of therapy followed by immune checkpoint inhibitor-based regimens.
The Moderating Impact of Perceived Risk on the Relationship of Website Experience and Online Purchase Intention

It is crucial to develop an understanding of the factors of customer purchase intention. It is also imperative to study these factors in the context of online purchasing. The reason its dissemination among consumers. Therefore, the present study developed a theoretical model and test by exploring the attributes of website experience such as information quality, security and service, and website credibility and its effect on online purchase intention in the presence of perceived risk as a moderator. The study opted quantitative method through survey application. PLS methodology was adopted to evaluate the measurement and structural model. The study adds knowledge to the literature through the support of empirical shreds of evidence in the context of Pakistan’s retail sector. The indication of findings points out the meaningful association among constructs that maximize the profitability of the online retail service sector if addressed carefully and may also create greater competition for online retailers. The study also showcases Implications, limitations, and future recommendations that were also canvassed at the end of the paper.
The role of UDP-glycosyltransferases in xenobioticresistance

Abstract Uridine diphosphate sugar-utilizing glycosyltransferases (UGTs) are an enzyme superfamily that catalyzes glycosyl residues transfer from activated nucleotide sugars to acceptor molecules. In addition to various endogenous compounds, numerous xenobiotics are substrates of UGTs. As the glycosides formed are generally less active/toxic and more hydrophilic than aglycones, UGTs effectively protect organisms from potentially harmful xenobiotics. Therefore, increased UGT expression and/or activity improve the protection of the organism and may contribute to the development of individuals that become more resistant to certain xenobiotics. While the function of UGTs in the resistance of human cancer cells to chemotherapy is now well known, other organisms and other xenobiotics have attracted much less attention. This review was designed to fill this knowledge gap by presenting complex information about the role of UGTs in xenobiotic-resistance in various organisms. This summarization and evaluation of the available information reveals that UGTs play an important role in defense against xenobiotics not only in humans, but in countless other organisms such as parasites, insects, and plants. Moreover, many recent studies clearly show the participation of UGTs in the resistance of nematodes to anthelmintics, insects to insecticides, weeds to herbicides as well as humans to various drugs (not only those used in cancer therapy but also in the treatment of epilepsy, psychiatric disorders, hypertension, hypercholesterolemia, and HIV infection). Nevertheless, although the contribution of UGTs to xenobiotic resistance in diverse organisms has become obvious, many pieces of information remain missing, for example with regard to the mechanisms of UGT regulation.
Experimental validation of a wireless system for the irrigation management in smart farming applications

This work is aimed at presenting the water saving potentialities of a scalable smart irrigation system applied to precision agriculture. A fuzzy logic strategy is integrated in a distributed monitoring system based on the wireless sensor network technology. The optimal irrigation schedule is adaptively estimated according to the real‐time measurement of the soil status and the weather conditions. The objective of the system is to optimize the water content in the soil to (i) maximize the health status of the plants, (ii) improve the quality of the products, and (iii) reduce the waste of water. The proposed system has been prototyped and experimentally validated in an apple orchard, close to the city of Trento, in the north of Italy. The performances of the proposed system are compared with those of a standard irrigation scheduler to point out the amount of saved water as well as the improved stability of the soil moisture level. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2186–2189, 2016
Camrelizumab Combined with Radiotherapy Treating Locally Advanced Non-Small Cell Lung Cancer that has Failed Chemotherapy: A Case Report

Background: Recent advances in immunotherapy have led to a paradigm shift in lung cancer treatment, as well as treatment for several other solid tumors, in which immune checkpoint inhibitors are the most widely applied. Currently, the standard treatment for inoperable, locally advanced non-small cell lung cancer (NSCLC) is concurrent radiochemotherapy followed by 1 year of consolidation therapy with duvalizumab. However, for various reasons, only 20%-25% of patients with locally advanced NSCLC in China have undergone standardized treatment. Instead, a large number of patients have been treated with sequential chemoradiotherapy as an alternative option. However, there is no consensus regarding how to perform systemic treatment if/when chemotherapy is ineffective. We present a case of stage IIIB lung adenocarcinoma in which chemotherapy failed. Case Presentation: A 59-year-old man with lung adenocarcinoma (cT4N2M0, stage IIIB) was admitted to the authors’ hospital after six courses of chemotherapy. Chest computed tomography revealed an enlarged tumor, which confirmed the ineffectiveness of chemotherapy. Tissue immu nohistochemistry revealed that the proportion of PD-L1-positive tumor cells accounted for >50% of cells. Accordingly, he was treated with cam- relizumab (200mg once every two weeks) in combination with thoracic radiotherapy (intensity-modulated radiation therapy, DT: 6600cGy/33F). Subsequently, he continued to receive camrelizumab as a consolidation treatment and has undergone 12 cycles to date. Every three months, the tumor continued to shrink and no severe immune-related adverse events were observed. Therapeutic efficacy was evaluated as a partial response. Conclusion: In this case of stage IIIB lung adenocarcinoma where chemotherapy failed, concurrent immunoradiotherapy followed by consol- idation camrelizumab therapy led to a successful response, with an encouraging clinical outcome. This report provides clinicians with a possible alternative strategy for the treatment of locally advanced NSCLC that does not respond to chemotherapy.
Utilizing Microservices Architecture for Enhanced Service Sharing in IoT Edge Environments

Latency sensitive IoT (Internet of Things) applications at the edge are designed using a microservice-based architecture. This architecture is comprised of a set of microservices, each implementing a simple functionality with clearly-defined interfaces, and applications are constructed by selecting and interconnecting appropriate microservices. To understand the performance implications of using a microservice-based architecture for constructing IoT applications at the edge, this paper provides a detailed evaluation based on an actual prototpye implementation and performance measurement. In our setup, an edge server fulfills dual roles of being an administrative controller of the IoT infrastructure and satisfying application’s latency and privacy constraints. We demonstrate the utility of this architecture by isolated and independent implementation of different microservices, constructing an IoT application by interconnecting these microservices, and potential sharing of microservices between different IoT applications running simultaneously to enhance interoperability. Finally, we provide an extensive performance evaluation focusing on application latency as well as CPU and memory consumption.
Auditory information and its parameters in health persuasion The development of a tailored smartphone application to support behavior change

While searching for ways to adopt a healthy lifestyle, fruit and vegetables can not be ignored. Consuming sufficient fruit and vegetables has positive health effects and plays a role in the prevention of cancer. Therefore, it is important to investigate how people can be stimulated to take up this behavior. There are new possibilities to present health information; for instance, we can listen to persuasive health information via an Audiobook or interactive smartphone app. This dissertation firstly describes the conditions under which this auditory health information can be effective: for whom is it effective, how does the information need to be formulated? In addition, this research addresses the efficacy of auditory information as presented via a smartphone app. Although there are ten thousands of health apps, the efficacy of such apps has never been tested according to the most strict scientific standard;: a randomized field experiment. The first studies show that it is important how the information is communicated: Aspects of the auditory message, such as intonation and background music, influence the process of health behavior change. In addition, aspects of the listener play a role as well, such as his or her personal involvement. The randomized field experiment showed that after six months of using the interactive fruit and vegetable smartphone app with auditory information and feedback, respondents consumed significantly more fruit. The results were less clear for vegetable consumption. With the gained knowledge in this dissertation, effective smartphone apps can now be created and new research questions and challenges are stimulated in health promotion research.