Miracle-dz/UniFAR-FTUs huggingface dataset:
GC-MS Analysis, Gastroprotective and In Silico Docking Studies of Phytoconstituents from Ixora Javanica Flowers

Ixora javanica belongs to the family Rubiaceae having phytoconstituents that are useful in the treatment of various diseases. In our study, the methanolic extract of Ixora javanica flowers was screened for its antiulcer activity. The extract was analyzed using GC-MS to identify significant active constituents, and these constituents were subjected to molecular docking to study their affinity towards the H+/K+ ATPase enzyme. The dry powder of the Ixora javanica flowers was extracted by methanol as the solvent for the soxhlation technique. The extract was then subjected to the GC-MS examination. The in-vivo antiulcer activity was screened using ethanol, indomethacin in pylorus ligation induced gastric ulcer models. The pharmacological evaluation of the extract was carried out using 200 and 400 mg/kg bd. wt. Omeprazole (20 mg/kg, bd.wt, p.o) was used as the standard. Ulcer scores were calculated. Glide 5.6 (Schrodinger Inc.) was used for generating docking simulation studies. The various phytochemical constituents identified from GC-MS study were formononetin, ferulic acid, quinic acid, palmitic acid, oleanolic acid and maslinic acid in higher amounts. The extract exhibited a substantial reduction in the ulcer scores in ethanol, indomethacin, and pylorus ligation prompted gastric ulcer prototypes. A decrease in the ulcers might be due to the presence of phytochemical constituents like terpenoids, flavonoids, phenolic acids, glycosides, alkaloids, steroids, saponins, and tannins present in Ixora javanica flowers, which clearly showed that the extract possesses gastroprotective activity. Molecular docking studies confirmed the H+/K+ ATPase inhibitory effect. Among the identified constituents, formononetin, ferulic acid, and rutin have shown the highest docking scores when compared to other compounds.
The Data mining technique in the prediction of diabetic retinopathy for community

The retinal malfunctioning caused during diabetes is popularly known as Diabetes retinopathy (DR) which is severe disease of the retina and is emerging as threat cause of less sightedness in the world. Eye using optical coherence tomography (OCT), and photographs of fundus and for appraise of the thickness and the structure of the retina, furthermore for the discernment of edema, bleeding, and scarring. Deep learning models are particularly used for the analysis of OCT images, or fundus images, extraction of features that are unique to each period of study. and, in ramification, the classification of the images, and the stage of the disease. During this work, it is deep the neural network (CNN), with 24 of convolutional layers and 4 fully-connected layers for the analysis of fundus images, and to distinguish between the control , moderate degree (i.e., a coalescence of mild and moderate Non-proliferative (D (NPDR) and severe degree (i.e., a group of severe NPDR, and keeps the DR (PDR)) the validation of the precision and accuracy of 88% -89%, a sensitivity of 87% -89%, and a specificity of 94% to 95% and the quadratic weighted Kappa scores of 0.91–0.92, with a 5-fold and 10-fold cross-validation methods, respectively. The last preprocessing phase has been carried out for both the class-specific image size, and the data on the growth rate were to be applied. The proposed approach is significantly more accurate in the objective diagnosis and classification of diabetic retinopathy, which eliminates the need for retinal imaging, and extend access to the retina, or treatment. This technology allows for early diagnosis, as well as the purpose of the monitoring of the progression of the disease, which may help in the optimization of medical therapy in order to denigrate the loss of visual function.
Pulmonale Hypertonie und körperliche Belastbarkeit

Exercise and Pulmonary Hypertension. Pulmonary hypertension is characterized by progressive pulmonary vascular remodeling with increase in vascular resistance, which can lead to right heart failure. Despite improvements in medical treatment options, patients often remain symptomatic and have reduced exercise capacity, quality of life and increased mortality. Moreover, reduced exercise capacity is associated with depression and anxiety disorders. In the past years, numerous studies examined the efficacy of medical therapy in patients with pulmonary hypertension, but little is known about the effects of physical activity in these patients. J Kardiol 2009; 16: 342–4.
The Influences of Transformational Leadership, Career Development, and Compensation to Job Satisfaction at Padang State University

This research aimed at finding out the influences of transformational leadership, career development, and compensation to job satisfaction at Padang State University. This study used 30 employees as sample at Padang State University. Questionnaire was used as a research instrument and distributed to the employees who were designated as respondents. The analysis method used Partial Least Square (PLS). The research showed some results: First, transformational leadership had a significant effect on job satisfaction; second, transformational leadership had a significant effect on compensation; third transformational leadership had a significant effect on career development; fourth, career development had no significant effect on job satisfaction; and fifth, compensation had a significant effect on job satisfaction.
Magnetic Biopolymeric Hydrogel Composite Material with Self-healing Attribute

This work presents a polysaccharide-based magnetic self-healing hydrogel fabricated through the incorporation of surface modified magnetic nanoparticles, a silica-surface modified magnetic Fe3O4@SiO2, (MNP), to a polymer composite synthesized from the oxidation of xanthan gum (XG) and it's crosslinking with chitosan (CS) to generate Schiff base linkages rendering selfhealing character. Fourier transform infrared (FT-IR) spectroscopy analyses revealed the successful formation of Schiff base bonding in the CS-OXG and CS-OXG-MNP hydrogels. In incorporating surface-modified magnetic nanoparticles, the resulting CS-OXG-MNP hydrogel with a weight ratio of 1:1:0.2, respectively, exhibited a better self-healing hydrogel in terms of faster self-healing characteristics and stronger mechanical property.
EXAMINING THE RELATIONSHIP BETWEEN SME’S ORGANIZATIONAL FACTORS AND EMPLOYEE CREATIVITY

Organizations with proper Human Resource (HR) practices play an exemplary role in developing their employees’ innovation. Though there is extensive literature on managing organizational innovation, even in today’s scenario some organizations barricade employees’ growth and innovation at the workplace. This study aimed to holistically explore the organizational factors affecting employee innovation using Principal Component Analysis (PCA) for factorizing sub-items and understand the relationship between various organizational factors and employee innovation using correlation analysis. The study executed a survey questionnaire and collected useful data from two hundred and fifty (250) respondents of various Saudi SME companies. The study developed sub-items and evolved into nine major organizational factors influencing employee innovation namely corporate structure, corporate culture and environment, organization strategy, innovation, employee, technology, resources, knowledge management, and management support. The hypotheses developed were tested with the collected data. The study found all the factors except corporate strategy and corporate culture and environment demonstrated a significant positive relation with employee innovation. The study recommended that any firm must focus on these factors to encourage employee innovation leading to overall organizational success. It also provides broad implications to HR managers, firm policymakers and top management to reassess and formulate the best organizational strategies to promote a culture of innovation in the organization.
Study of Calcium Phosphate (OCP) Electrodeposition Process on Elektron 21 Magnesium Alloy Surface

Contribution deals with evaluation of the electrodeposition process of octacalcium phosphate layer on the surface of Elektron 21 magnesium alloy. The octacalcium phosphate coating (OCP) was electrochemically deposited in a solution containing 0.167 M CaCl2 and 0.1 M NH4H2PO4. The formation of calcium phosphate was divided into several stages and described using light microscopy. The influence of octacalcium phosphate layer on the electrochemical characteristics of Elektron 21 magnesium alloy was evaluated by potentiodynamic measurements in 0.1 M NaCl solution at a temperature 22 ± 1°C. Evaluation of calcium phosphating process realized on the alloy surface after grinding was investigated by electrochemical tests supported by photodocumentation using stereomicroscope.
Uncertainty-Aware Digital Diagnosis from Sounds

The popularity of mobile sensors, particularly, microphones, with artificial intelligence is reshaping respiratory disease diagnosis and monitoring. Through deep learning, preferable performance can be achieved in-thelab settings. However, deep learning generally lacks explainability and is sensitive to input data shifts. Most importantly, these models are over-confident leading to irrational decisions which have severe healthcare consequences. In this regard, to allow extensive deployment of automatic diagnosis, a proper understanding of the confidence of digital output is indispensable. Uncertainty estimation in deep learning is a key solution to the aforementioned issue. Though softmax probability indicates the confidence of the prediction, to some extent, it only captures the relative probability that an instance is from a particular class, and it tends to overestimate confidence and thus requires further calibration. In brief, probabilistic approaches have been proposed to estimate uncertainty more accurately. However, they have not been well explored in soundbased disease detection models [1]. With uncertainty, the system is aware of the risk of automatic diagnosis and it is able to refer samples with low predictive confidence to doctors for reliable results. Consequently, the robustness of the system and the safety of patients can be improved simultaneously. Also, the estimated uncertainty itself, as a feedback signal, is helpful to boost the performance of deep learning. All these considerations pave the way for a more practical sound-based automatic diagnosis system.
The Impact of Services Quality on Brand Experiences: The Mediating Role of Customer Engagement

The primary purpose of this study is to analyze: (1) The impactof Services Quality on Customer Engagement, (2) The impactof Services Quality on Brand Experiences, (3) The impactof Services Quality on Brand Exeriences through Customer Engagement, (4) The impactof Customer Engagement on Brand Experiences.This research using causative researchwith total sample was 151 people by using questionnaire. The result of study showed that (1) Services Quality has significant effect on Customer Engagement, (2) Services Quality has no effect on Brand Experiences, (3) Services Quality has significant effect on Brand Experiences trhough Customer Engagement, (4) Customer Engagement has significant effect on Brand Experiences.
Preliminary Evidence of Rickettsia slovaca and Rickettsia conorii Infection in the Sera of Sheep, Dogs and Deer from an Area of Northern Spain

Limited information is available on the presence of rickettsial infection in animal reservoirs in Spain. Antibodies against Rickettsia slovaca and Rickettsia conorii were therefore sought in the sera of farm, domestic and wild animals (n = 223 samples) in an area of northern Spain. Indirect immunofluorescence assays showed: (A) 17/120 and 16/120 (14.2% and 13.3%) of serum samples from sheep (farm animals) reacted with R. slovaca and R. conorii antigens, respectively; (B) 10/73 and 10/73 (13.7% and 13.7%) of samples from dogs (domestic animals) did the same; (C) as did 22/30 and 20/30 (73.3% and 66.6%) of samples from deer (wild animals) (overall titre range: 1/40 to 1/1280). The prevalence of both types of infection was significantly greater in the wild animals than either the farm or domestic animals. The largest titres were recorded for R. slovaca in all three groups.
J ul 2 02 1 The information loss of a stochastic map

We provide a stochastic extension of the Baez–Fritz–Leinster characterization of the Shannon information loss associated with a measure-preserving function. This recovers the conditional entropy and a closely related information-theoretic measure that we call ‘conditional information loss. ’ Although not functorial, these information measures are semi-functorial, a concept we introduce that is definable in any Markov category. We also introduce the notion of an ‘entropic Bayes’ rule’ for information measures, and we provide a characterization of conditional entropy in terms of this rule.
Clinical Utility of a ChemoFx® Drug Response Assay for Gynecologic Malignancies

Objective: To assess the utility of a chemoresponse assay (ChemoFx®) in planning for gynecologic malignancies. Study Design: A retrospective chart review from November 2008 July 2012 identified patients at 3 institutions with a tissue specimen sent to Precision Therapeutics for in-vitro chemosensitivity testing via ChemoFx®. Chemosensitivity testing was performed on tumors from 71 Patients with Uterine, Cervical, Ovarian and nonGynecologic primary cancers. Tumors were classified as responsive (RR), intermediately responsive (IR), and nonresponsive (NR) to multiple chemotherapeutic regimens. Overall survival based on treatment concordance and chemotherapy used was assessed using descriptive statistics and Kaplan Meier survival plots. Results: There was a mean survival benefit for patients treated with RR (39.6 months) over IR (21.3 months) or NR (18 months) (p = 0.03). There was a trend towards significance (p = 0.068) of prolonged overall survival when C/T was RR when compared to those when C/T was IR or NR. Conclusion: When prescribed accordingly, a responsive chemotherapy regimen on ChemoFx® is associated with an improved overall survival in patients with a gynecologic malignancy regardless of stage of disease, disease type, or residual disease.
Extended Irreversible Thermodynamics

Der vorliegende Band enthált sechs Beitrage, in denen punktuell und exemplarisch der Stand der Forschung beleuchtet wird. Ein Beitrag von Codling und Frasinski beschreibt in erster Linie Experimente zum noch wenig verstandenen Phânomen der dissoziativen Ionisation von Molekülen, bei dem diese in einem intensiven Laserfeld mehrere Elektronén verlieren und in Ionen mit hoher kinetischer Energie zerfallen. Ein wesentlicher Teil dieses Beitrags widmet sich einer von den Autoren entwickelten Auswertungstechnik, welche die Korrelationen zwischen den Fiugzeiten emittierter Ionen und Elektronén sichtbar macht. Es folgen drei Beitrage zur Théorie. Schmelcher und Cederbaum beschreiben Effekte starker statischer Felder, die nur dann zu verstehen sind, wenn die Nicht-Separation der Schwerpunktsbewegung im auBeren Magnetfeld korrekt beriicksichtigt wird. Dies fiihrt
Aragie et al., 2016

Developing countries identify a set of strategic objectives to promote agricultural production, and assure food security and reduced level of poverty. Two of these objectives are (i) sustainable increase in agricultural productivity, and (ii) accelerated agricultural commercialization. Each of these objectives is backed-up by a long-list of priority investment areas. However, most of these countries cannot satisfy the financial and technical requirements to execute both of the strategic objectives and all of these investment areas. In light of this, taking the case of Ethiopia as an example, this study employs an economy-wide model and assesses the relative efficiency of alternative investment options on agricultural performance and poverty reduction. Results show that the policy instruments cause significantly different production and welfare responses. Productivity enhancing interventions such as input subsidy and irrigation provision have superior welfare consequences, while policies aimed at small holder commercialization have the least effect.
Brain Lateralization and Cognitive Capacity

Simple Summary We used to think of brains as symmetrical, functioning in the same way on the left and right sides, but we now know that this is not so. From the small brains of insects to variously sized brains of vertebrates, including humans, the left and right sides process information differently and control different patterns of behaviour. This is known as lateralization. Lateralized brains can carry out different functions simultaneously on the left and right sides (e.g., monitoring for predators while searching for food). Avoiding duplication in this way increases cognitive capacity. This paper considers the cognitive advantages of two kinds of lateralization. The first, known as individual lateralization, means that most individuals in a species are lateralized, roughly half in one direction and the other half in the other direction. The second type of lateralization, known as directional or population lateralization, means that most individuals have the same direction of lateralization. Directional lateralization is important for social behaviour but, as this paper argues, it may not increase cognitive capacity any more than does individual lateralization. Strength of lateralization is discussed and so is the communication between the left and right sides of the brain. Abstract One way to increase cognitive capacity is to avoid duplication of functions on the left and right sides of the brain. There is a convincing body of evidence showing that such asymmetry, or lateralization, occurs in a wide range of both vertebrate and invertebrate species. Each hemisphere of the brain can attend to different types of stimuli or to different aspects of the same stimulus and each hemisphere analyses information using different neural processes. A brain can engage in more than one task at the same time, as in monitoring for predators (right hemisphere) while searching for food (left hemisphere). Increased cognitive capacity is achieved if individuals are lateralized in one direction or the other. The advantages and disadvantages of individual lateralization are discussed. This paper argues that directional, or population-level, lateralization, which occurs when most individuals in a species have the same direction of lateralization, provides no additional increase in cognitive capacity compared to individual lateralization although directional lateralization is advantageous in social interactions. Strength of lateralization is considered, including the disadvantage of being very strongly lateralized. The role of brain commissures is also discussed with consideration of cognitive capacity.
Title: Adaptation to Full-field Contrast Encoding in Distinct Layers of Macaque Primary

The neocortex is composed of six main layers of neurons that form an intricate micro22 circuit with connections within a cortical area and the rest of the brain (Callaway, 1998). This laminar 23 circuit motif has been proposed to be the fundamental module of cortical computational processes 24 (Mountcastle, 1978; Douglas and Martin, 2010). However, the algorithmic principles as well as the func25 tional role of each layer remain unclear to date. In this study, we conducted a systematic investigation 26 of the information coding properties for stimulus contrast across different cortical layers of the macaque 27 primary visual cortex. We adopted an approach using a uniform-field flicker stimulus with alternating 28 contrast conditions and analyzed the statistical features of the distribution of stimuli that elicited spikes 29 (Smirnakis et al. 1997; Meister and Berry, 1999; Liu and Gollisch, 2015) as a function of time after the 30 transition. Neural responses were modelled as linear-nonlinear (LN) functions (Schwartz et al., 2006), 31 whose linear component was taken to be proportional to the neurons’ spike-triggered average (STA) 32 responses. We found that both the parameters of the STA and the nonlinearity during the steady-state 33 contrast response varied systematically both between contrast levels and across cortical depths. Closer 34 investigation of the dynamics of adaptation to new contrast conditions revealed a rich repertoire of 35 trajectories for the firing rate, the STA and the nonlinearity. 36
آسیب کروموزومی ناشی از رادیونوکلئیدهای گسیلنده الکترونهای اوژه با استفاده از مدل ZBB1 در کد GEANT4

1 کیزیف هورگ ، رون مایپ هاگشناد ناریا ،نارهت ، . 2 رنا یسدنهم هدکشناد ژ و ی کیزیف ، هاگشناد ،ریبکریما نارهت ناریا ، . * یسدنهم هدکشناد ،ریبکریما هاگشناد ،نارهت رنا ژ ی کیزیف و :یتسپدک ، 1591634311 تسپ یکینورتکلا : pysham@aut.ac. ir هدیکچ تقو ی اهوترپ ی نازینوی م هدنز لولس دراو ی وش ن لولس هدام اب ،د ی لماعت یم نک ن و د رد هجیتن رادقم ی ژرنا زا ی م للقتنم نآ هب ار دوخ ی نک لن ا رد . د لی ن نورتکلا راشتنا ،هعلاطم اه ی وا هژ نآ تارثا و هب اه لسآ ناونع هلب بی DNA هب لسو هلی لخرب ی دار زا اهدلیئلکونوی لننام د Tc 99m ، In 111 ، I 125 و I 123 الب رازبا زا هدافتسا Geant4-DNA لدم اب 1ZBB یسررب دروم م . تفرگ رارق لد 1ZBB هناخباتک زا نیئتورلپ تاعلاطا کناب لختنا . تلسا هدلش با دادعت تسکش هتشرود یاه یا هب عبات ناونع ی ژرنا زا ی ش هداد ناشن د . شیب هک تسا هدش هداد ناشن هعلاطم نیا رد بیسآ نیرت نورتکلا طسوت اه یاه یژرنا اب هژوا مک یاه نورتکلاولیک کی زا رت تلو هیلا هب طوبرم و M و N یم . دشاب
ZEB2, the Mowat-Wilson Syndrome Transcription Factor: Confirmations, Novel Functions, and Continuing Surprises

After its publication in 1999 as a DNA-binding and SMAD-binding transcription factor (TF) that co-determines cell fate in amphibian embryos, ZEB2 was from 2003 studied by embryologists mainly by documenting the consequences of conditional, cell-type specific Zeb2 knockout (cKO) in mice. In between, it was further identified as causal gene causing Mowat-Wilson Syndrome (MOWS) and novel regulator of epithelial–mesenchymal transition (EMT). ZEB2’s functions and action mechanisms in mouse embryos were first addressed in its main sites of expression, with focus on those that helped to explain neurodevelopmental and neural crest defects seen in MOWS patients. By doing so, ZEB2 was identified in the forebrain as the first TF that determined timing of neuro-/gliogenesis, and thereby also the extent of different layers of the cortex, in a cell non-autonomous fashion, i.e., by its cell-intrinsic control within neurons of neuron-to-progenitor paracrine signaling. Transcriptomics-based phenotyping of Zeb2 mutant mouse cells have identified large sets of intact-ZEB2 dependent genes, and the cKO approaches also moved to post-natal brain development and diverse other systems in adult mice, including hematopoiesis and various cell types of the immune system. These new studies start to highlight the important adult roles of ZEB2 in cell–cell communication, including after challenge, e.g., in the infarcted heart and fibrotic liver. Such studies may further evolve towards those documenting the roles of ZEB2 in cell-based repair of injured tissue and organs, downstream of actions of diverse growth factors, which recapitulate developmental signaling principles in the injured sites. Evident questions are about ZEB2’s direct target genes, its various partners, and ZEB2 as a candidate modifier gene, e.g., in other (neuro)developmental disorders, but also the accurate transcriptional and epigenetic regulation of its mRNA expression sites and levels. Other questions start to address ZEB2’s function as a niche-controlling regulatory TF of also other cell types, in part by its modulation of growth factor responses (e.g., TGFβ/BMP, Wnt, Notch). Furthermore, growing numbers of mapped missense as well as protein non-coding mutations in MOWS patients are becoming available and inspire the design of new animal model and pluripotent stem cell-based systems. This review attempts to summarize in detail, albeit without discussing ZEB2’s role in cancer, hematopoiesis, and its emerging roles in the immune system, how intense ZEB2 research has arrived at this exciting intersection.