Miracle-dz/UniFAR-FTUs huggingface dataset:
Screening for lung cancer: 2023 guideline update from the American Cancer Society.

Lung cancer is the leading cause of mortality and person-years of life lost from cancer among US men and women. Early detection has been shown to be associated with reduced lung cancer mortality. Our objective was to update the American Cancer Society (ACS) 2013 lung cancer screening (LCS) guideline for adults at high risk for lung cancer. The guideline is intended to provide guidance for screening to health care providers and their patients who are at high risk for lung cancer due to a history of smoking. The ACS Guideline Development Group (GDG) utilized a systematic review of the LCS literature commissioned for the US Preventive Services Task Force 2021 LCS recommendation update; a second systematic review of lung cancer risk associated with years since quitting smoking (YSQ); literature published since 2021; two Cancer Intervention and Surveillance Modeling Network-validated lung cancer models to assess the benefits and harms of screening; an epidemiologic and modeling analysis examining the effect of YSQ and aging on lung cancer risk; and an updated analysis of benefit-to-radiation-risk ratios from LCS and follow-up examinations. The GDG also examined disease burden data from the National Cancer Institute's Surveillance, Epidemiology, and End Results program. Formulation of recommendations was based on the quality of the evidence and judgment (incorporating values and preferences) about the balance of benefits and harms. The GDG judged that the overall evidence was moderate and sufficient to support a strong recommendation for screening individuals who meet the eligibility criteria. LCS in men and women aged 50-80 years is associated with a reduction in lung cancer deaths across a range of study designs, and inferential evidence supports LCS for men and women older than 80 years who are in good health. The ACS recommends annual LCS with low-dose computed tomography for asymptomatic individuals aged 50-80 years who currently smoke or formerly smoked and have a ≥20 pack-year smoking history (strong recommendation, moderate quality of evidence). Before the decision is made to initiate LCS, individuals should engage in a shared decision-making discussion with a qualified health professional. For individuals who formerly smoked, the number of YSQ is not an eligibility criterion to begin or to stop screening. Individuals who currently smoke should receive counseling to quit and be connected to cessation resources. Individuals with comorbid conditions that substantially limit life expectancy should not be screened. These recommendations should be considered by health care providers and adults at high risk for lung cancer in discussions about LCS. If fully implemented, these recommendations have a high likelihood of significantly reducing death and suffering from lung cancer in the United States.
Object-oriented and pixel-based classification approaches to classify tropical successional stages using airborne high–spatial resolution images

Airborne high–spatial resolution images were evaluated for mapping purposes in a complex Atlantic rainforest environment in southern Brazil. Two study sites, covered predominantly by secondary evergreen rainforest, were surveyed by airborne multispectral high-resolution imagery. These aerophotogrammetric images were acquired at four spectral bands (visible to near-infrared) with spatial resolution of 0.39 m. We evaluated different data input scenarios to suit the object-oriented classification approach. In addition to the four spectral bands, auxiliary products such as band ratios and digital elevation models were considered. Comparisons with traditional pixel-based classifiers were also performed. The results showed that the object-based classification approach yielded a better overall accuracy, ranging from 89% to 91%, than the pixel-based classifications, which ranged from 62% to 63%. The individual classification accuracy of forest-related classes, such as young successional forest stages, benefits the object-based approach. These classes have been reported in the literature as the most difficult to map in tropical environments. The results confirm the potential of object-based classification for mapping procedures and discrimination of successional forest stages and other related land use and land cover classes in complex Atlantic rainforest environments. The methodology is suggested for further SAAPI acquisitions in order to monitor such endangered environment as well as to support National Land and Environmental Management Protocols.
Geochemical studies of groundwater systems of semiarid Yola area, northeast, Nigeria

Geochemical studies of Yola area of Northeast Nigeria were studied during a dry season period (November 2008). This was to determine the process controlling the water chemistry and to assess the quality of water. The results show that, based on ionic ratios, precipitation and water-rock interaction (silicate weathering) are the main controlling factors contributing to solute concentration in these areas. The main water types in the area include Mg2+- HCO3 - and Na+-Cl- are the dominant ion types for the shallow groundwater, Mg2+-Cl-, Mg2+-HCO3 - and Na+-HCO3 - for the deep groundwater and Na+-Cl- for the surface water bodies. Equilibrium specification calculations revealed that the water samples are largely undersaturated with respect to calcite and dolomite in the water samples. Groundwater samples from the shallow groundwater indicate pH values (6.10 to 7.08) and Eh values (mean 0.72 volt) whereas those of the deep groundwater revealed pH range (6.60 to 7.80) and Eh values (mean 0.75 volt). They are slightly acidic to neutral, largely soft, clean waters with fairly low to moderate concentration of dissolved solids that fall within the international acceptable limits for drinking, domestic and irrigation purposes. However some samples indicate iron and nitrate values that are above the recommended limits and should be treated before use. Employing Electrical Conductivity (EC), Total Dissolved Solids (TDS), Sodium Adsorption Ratio (SAR), Magnesium Adsorption Ratio (MAR), Permeability Index (PI), Kellys Ratio (KR), and Residual Sodium Bicarbonate (RSBC) as criteria, the waters appear suitable for irrigation purposes.
A New Dragonfly Optimized Fuzzy Logic-based MPPT Technique for Photovoltaic Systems

Photovoltaic (PV) power systems should be operated at the maximum power point (MPP) for best solar energy utilization, which can be achieved using maximum power point tracking (MPPT) techniques. Perturb & Observe (P&O) and Fuzzy logic MPPT approaches were two of the various strategies that were suggested as effective ways to achieve Maximum Power under Continuous Irradiation. When exposed to changes in environmental conditions, these approaches perform poorly dynamically and exhibit substantial steady-state oscillations around the MPP. To overcome this problem, this paper proposes the Dragonfly optimization-based fuzzy logic MPPT approach for maximum power extraction of photovoltaic (PV) systems. The approaches for implementing FL-based MPPTs that are currently available are not adaptable to the operating point, which varies widely in real-world PV systems with operational irradiance and ambient temperature. The proposed MPPT (DAFLC-MPPT) is straightforward, accurate, and offers quicker convergence to the optimal operating point. With consideration of various operating situations at slow and fast changes in solar radiation, the efficacy and viability verifications of the proposed AFL-MPPT approach are validated. The proposed strategy outperforms the standard P&O and fuzzy logic methods.
In Vitro Anti-Diabetic, Anti-Inflammatory, Antioxidant Activities and Toxicological Study of Optimized Psychotria malayana Jack Leaves Extract

Psychotria malayana Jack (Family: Rubiaceae, local name: Salung) is a traditional herb used to treat diabetes. A previous study by our research group demonstrated that P. malayana methanolic and water extract exhibits significant potential as an effective agent for managing diabetes. Further research has been performed on the extraction optimization of this plant to enhance its inhibitory activity against α-glucosidase, a key enzyme associated with diabetes, and to reduce its toxicity. The objectives of this study are to evaluate the anti-diabetic, anti-inflammatory, and antioxidant properties of the optimized P. malayana leaf extract (OE), to evaluate its toxicity using a zebrafish embryo/larvae model, and to analyze its metabolites. The anti-diabetic effects were assessed by investigating α-glucosidase inhibition (AGI), while the inflammation inhibitory activity was performed using the soybean lipoxygenase inhibitory (SLOXI) test. The assessment of antioxidant activity was performed utilizing FRAP and DPPH assays. The toxicology study was conducted using the zebrafish embryo/larvae (Danio rerio) model. The metabolites present in the extracts were analyzed using GC-MS and LC-MS. OE demonstrated significant AGI and SLOXI activities, represented as 2.02 and 4.92 µg/mL for IC50 values, respectively. It exhibited potent antioxidant activities as determined by IC50 values of 13.08 µg/mL (using the DPPH assay) and 95.44 mmol TE/mg DW (using the FRAP assay), and also demonstrated an LC50 value of 224.29 µg/mL, which surpasses its therapeutic index of 111.03. OE exhibited a higher therapeutic index compared to that of the methanol extract (13.84) stated in the previous state of the art. This suggests that OE exhibits a lower level of toxicity, making it safer for use, and has the potential to be highly effective in its anti-diabetic activity. Liquid chromatography–mass spectrometry (LC-MS) and gas chromatography–mass spectrometry (GC-MS) demonstrated the presence of several constituents in this extract. Among them, several compounds, such as propanoic acid, succinic acid, D-tagatose, myo-inositol, isorhamnetin, moracin M-3′-O-β-D-glucopyranoside, procyanidin B3, and leucopelargonidin, have been reported as possessing anti-diabetic and antioxidant activities. This finding offers great potential for future research in diabetes treatment.
A Method for Quantifying Back Flexion/Extension from Three Inertial Measurement Units Mounted on a Horse’s Withers, Thoracolumbar Region, and Pelvis

Back mobility is a criterion of well-being in a horse. Veterinarians visually assess the mobility of a horse’s back during a locomotor examination. Quantifying it with on-board technology could be a major breakthrough to help them. The aim of this study was to evaluate the accuracy of a method of quantifying the back mobility of horses from inertial measurement units (IMUs) compared to motion capture (MOCAP) as a gold standard. Reflective markers and IMUs were positioned on the withers, eighteenth thoracic vertebra, and pelvis of four sound horses. The horses performed a walk and trot in straight lines and performed a gallop in circles on a soft surface. The developed method, based on the three IMUs, consists of calculating the flexion/extension angle of the thoracolumbar region. The IMU method showed a mean bias of 0.8° (±1.5°) (mean (±SD)) and 0.8° (±1.4°), respectively, for the flexion and extension movements, all gaits combined, compared to the MOCAP method. The results of this study suggest that the developed method has a similar accuracy to that of MOCAP, opening up possibilities for easy measurements under field conditions. Future studies will need to examine the correlations between these biomechanical measures and clinicians’ visual assessment of back mobility defects.
Situational Awareness in the Context of Clinical Practice

In the context of clinical practice, situational awareness refers to conscious awareness (knowledge), which is a mental model of a given clinical situation in terms of its elements and the significance of their interrelation. Situational awareness (SA) facilitates clinical reasoning, diagnostic accuracy, and appropriate goal-directed performance, and it enables clinicians to immediately adapt treatment strategies in response to changes in clinical situational actualities and to modify the course of goal-directed activities accordingly. It also helps clinicians prepare future operational plans and procedures based on the projection of situational developments. SA, therefore, is an important prerequisite for safe clinical procedures. The purpose of this narrative review is to highlight certain cognitive and external (environmental) situational factors that influence the development of situational awareness. Understanding the dynamic, adaptive, and complex interactions between these factors may assist clinicians and managers of healthcare systems in developing methods aimed at facilitating the acquisition of accurate clinical situational awareness and, in turn, may bring about a reduction in the incidence of SA, diagnostic, and operational errors.
Palaeomagnetism and 40Ar/39Ar dating from Lower Jurassic rocks in Gastre, central Patagonia: further data to explore tectonomagmatic events associated with the break-up of Gondwana

New 40Ar/39Ar data indicate ages of c. 185 Ma for the Lonco Trapial volcanic field in Gastre, north–central Patagonia, implying that this andesitic unit is roughly coeval with the Marifil silicic province that crops out in the eastern part of northern Patagonia. These volcanic fields are therefore roughly coeval with the Karoo–Ferrar large igneous province, further contributing to the huge, 185–180 Ma magmatic outpouring in southern Gondwana. The comparison of palaeomagnetic results from the unit with Early Jurassic reference palaeopoles suggests that Gastre records a small, anticlockwise finite rotation with respect to stable South America. This contrasts sharply with the large clockwise rotation recorded by roughly coeval dolerites from the Falkland/Malvinas Islands, and argues against a direct relationship between the rotation of the islands and the tectonic activity in Gastre. The results support previous suggestions that the Gastre Fault System is not the locus of major strike-slip displacement activity in the Jurassic as some workers have suggested. Taken as a whole, palaeomagnetic data from Patagonia suggest a more complex than previously thought pattern of distributed and variable deformation during the early stages of Gondwana breakup. The crustal block boundaries in the region remain cryptic. Supplementary material: 40Ar/39Ar analytical procedures and expanded data are available at http://www.geolsoc. org.uk/SUP18522.
Imputabilidad e inimputabilidad

Sin duda alguna la capacidad humana para comprender el caracter ilicito de los actos al momento de realizar una conducta tipica ha sido un tema del cual la dogmatica penal se ha ocupado desde anos atras. El analisis de esta tematica ha llevado a revisar aspectos tales como, elementos para su configuracion, sus consecuencias y efectos en la punibilidad de la conducta entre otros.
Were Immigrants a Significant Part of the Earliest Paleocene Mammalian Fauna of the North American Western Interior

The roles of immigration and endemic radiation of survivors of the extinctions marking the Cretaceous/Tertiary (K/T) boundary in evolution of the earliest Paleocene (Puercan) mammalian fauna of the North American Western Interior have been debated. Continued field and laboratory research has significantly expanded and refined knowledge of the compositions of North American latest Cretaceous (Lancian North American Land Mansmal Age) and Puercan 1 (Put) local faunas. It has also revealed limitations in biochronological correlations of these local faunas. In general, Pul local faunas of the northern Western Interior reflect the extinction or extirpation of lineages of Lancian marsupials and consist primarily of multituberculate and eutherian mammals. The majority of Pul mammals were immigrants, many dispersing into the area soon after the K/T boundary. Testing the hypothesis of Asian origins of the immigrants is hampered by lack of latest Cretaceous or earliest Paleocene mammalian local faunas particularly from high North American paleolatitudes and Pacific coastal areas of Asia. Another working hypothesis, that most, if not all, of the Pul immigrant mammals entering the northern Western Interior could have dispersed from other areas of the North American continent has increasing support and has yet to the falsified.
Screening, Expression and Identification of Nanobody Against Monkeypox Virus A35R

Introduction The monkeypox (Mpox) virus epidemic presents a significant risk to global public health security. A35R, a crucial constituent of EEV, plays a pivotal role in virus transmission, serves as a vital target for vaccine development, and has potential for serological detection. Currently, there is a dearth of research on nanobodies targeting A35R. The purpose of this study is to identify specific nanobodies target A35R, so as to provide new antibody candidates for Mpox vaccine development and diagnostic kit development. Methods Three nanobodies specific to the monkeypox virus protein A35R were screened from a naïve phage display library. After four rounds of panning, positive phage clones were identified by enzyme-linked immunosorbent assay (ELISA). Further, the nanobody fusion protein was constructed in pNFCG1-IgG1-Fc vector and expressed in HEK293F cells and purified by affinity chromatography. The specificity and affinity of the nanobodies were identified by ELISA. The binding kinetics of the VHH antibody to A35R were assessed via employment of a bio-layer interferometry (BLI) apparatus, thereby determining the nanobodies affinity. Results The three purified nanobodies showed specific high-affinity binding MPXV A35R, of them, VHH-1 had the best antigen binding affinity (EC50 = 0.010 ug/mL). In addition, VHH-1 on Protein A biosensor can bind Mpox virus A35R, with an affinity constant of 54 nM as determined in BLI assay. Conclusion In sum, we has obtained three nanobody strains against Mpox virus A35R with significant affinity and specificity, therefore laying an essential foundation for further research as well as the applications of diagnostic and therapeutic tools of Mpox virus.
Finger Print of Arsenic Contaminated Water in India-A Review

The present study deals primarily with the arsenic contamination occur in ground water in all over India, its causes, effects and recommendation. Arsenic above permissible limit in ground water of phreatic younger alluvium of Ganga and Ghaghara rivers along meandering course and shallow aquifer, has reported as the main source of arsenic contamination. Several studies have been carried out on this context; which is still limited by a lack of data thus, a review study has been undertaken on the sources, causes and health prospective, arsenic is likely to disastrous effects on human. Due to excess of Arsenic in ground water people are reported to be suffering from diseases like skin cancer, ulcer and pigmentation in skin and hardening in palm skin. Different analytical methods have been proposed for further analysis to provide details to know the quantity of arsenic in water, its impact, identify the risk factors and possible to makes recommendation for the prevention and management of arsenic poisoning cases and study of probability of other heavy metals. This review work suggests that the arsenic concentration increase day by day through different channel. It’s directly and indirectly affecting human being; needs to be investigating thoroughly arsenic problem in India.
Towards a Framework for the Integration of Traditional Ecological Knowledge and Meteorological Science in Seasonal Climate Forecasting: The Case of Smallholder Farmers in Zimbabwe

Abstract Global evidence shows that seasonal climate forecasting can be a useful strategy in adapting to the effects of climate change on agricultural production. Meteorological science based seasonal climate forecasting hasbeen broadly promoted as an important adaptation tool in this regard. However, calls are now mounting for theintegration of meteorological based forecasting knowledge with traditional ecological knowledge based systems ofseasonal forecasting to minimize system deficiencies in forecasting. Using a mixed methods approach, the studyinvestigates the interface between the two knowledge systems and what integrating them would entail in practicein Matobo District, Zimbabwe. The paper finds that farmers are already utilizing both types of knowledge albeit inan uncoordinated fashion. Those farmers that integrate the two knowledge systems tended to make more definitivefarming decisions concerning seasonal climate patterns. The paper recommends a more systematic parallelintegration system that recognizes the importance of both knowledge systems.
Verified Encodings for SAT Solvers

Satisfiability (SAT) solvers are versatile tools that can solve a wide array of problems, and the models and proofs of unsatisfiability emitted by SAT solvers can be checked by verified software. In this way, the SAT toolchain is trustworthy. However, many applications are not expressed natively in SAT and must instead be encoded into SAT. These encodings are often subtle, and implementations are error-prone. Formal correctness proofs are needed to ensure that implementations are bug-free. In this paper, we present a library for formally verifying SAT encodings, written using the Lean interactive theorem prover. Our library currently contains verified encodings for the parity, at-most-one, and at-most-k constraints. It also contains methods of generating fresh variable names and combining sub-encodings to form more complex ones, such as one for encoding a valid Sudoku board. The proofs in our library are general, and so this library serves as a basis for future encoding efforts.
The Effect of Overview Displays on Situation Assessment

The impact of overview displays when operating in a simulated environment (SimCity 2000) was assessed. Subjects in one condition had access to a fixed overview display on a separate CRT (an additional display that was absent in the no overview display condition). The experimenter operated the simulation based on the verbal instructions of the subjects. More trends were detected, and more verbalizations, in the overview display condition. There was also more discussion of the simulation state and more transitions from commenting about states to preparing actions, with the overview display. It is argued that the methodology used in this study, and the results obtained, demonstrate that measures such as situation assessment may be easier to interpret than performance measures, and less variable, because they are less likely to be influenced by extraneous factors. Thus they may be more sensitive indicators of the effect of changes in display design.