Miracle-dz/UniFAR-FTUs huggingface dataset:
INFLUENCE OF SHORT-TERM AGEING AND LONG-TERM AGEING ON THE THERMAL EQUILIBRIUM TIME FOR TWO DIFFERENT VISCOSITY GRADES OF BITUMEN USED FOR ROAD CONSTRUCTION

: The field performance of bituminous roads depends highly upon the rheological properties of the bitumen used. Therefore, it is paramount that the determination of the rheological properties of bitumen binders is done accurately. Determining the time it takes for a specimen to reach the desired test temperature before starting any rheological examination is one such important aspect. This time is known as the time for thermal equilibrium. This study focuses on determining the time it takes for a specimen to achieve the thermal equilibrium. Here, the unaged, rolling thin film oven (RTFO) aged and pressure aging vessel (PAV) aged bitumen binders were subjected to an oscillatory test at 10 rad/s using a Dynamic Shear Rheometer (DSR) and the variation of the complex modulus with time was analyzed. The observed results clearly showed that the test temperature and aging significantly affects the time it takes for a sample to reach the thermal equilibrium.
Tracking the dynamic changes of a flavor, phenolic profile, and antioxidant properties of Lactiplantibacillus plantarum‐ and Saccharomyces cerevisiae‐fermented mulberry wine

Abstract The process of fermentation renders the superior quality of mulberry wine based on the microorganisms utilized. The present study aimed at investigating the changes and correlation between phenols and product quality of mulberry wine fermented with Lactiplantibacillus plantarum and Saccharomyces cerevisiae combinatorially. Total anthocyanins concentration (TAC), polyphenols concentration (TPC), flavonoids concentration (TFC), and antioxidant capacity decreased significantly with high correlation in the fermentation process. TAC gradually reduced with a loss rate of 47.98% from 0 to third day of fermentation. Fermented mulberry wine obtained indicated a dynamic balance due to the presence of p‐hydroxybenzoic acids as compared to the primary phenolic constituent. Chlorogenic acid usually presents in mulberry juice. The relative intensity of sourness was the most prominent and reached the maximum (10.93) on day 2 of fermentation. A total of 21 volatile esters were quantified (6621.59 μg/L), which contributed significantly to the aroma of mulberry wine. The enhanced quality of fermented mulberry wine showed contraindications with decreased constituents and escalated wine quality. Rather than usual single inoculum, fermentation combination of LAB and yeast holistically influenced the color, taste, fragrance, phenolic profiles, and antioxidant properties in mulberry wine, ensuring palatability and fit for commercialization prospects.
Utility of X-ray and indocyanine green fluorescence imaging in detecting hepatocellular carcinoma dissemination on laparoscopic surgery: A case report

Indocyanine green (ICG) fluorescence imaging is useful for the intraoperative detection of the peritoneal dissemination of hepatocellular carcinoma (HCC). However, in laparoscopic surgery, disseminations cannot be accurately identified unless the camera lens is positioned close to the lesion. The present study describes a case of HCC dissemination in which the lesions were accurately identified by combining intraoperative fluoroscopy with ICG fluorescence imaging. A 76-year-old male was diagnosed with HCC dissemination. Computed tomography revealed a 9-mm disseminated nodule near the gallbladder. Although transarterial chemoembolization had also been used to treat this lesion, chemoembolization was technically difficult to perform. Therefore, a coil was placed around the lesion to serve as an intraoperative landmark for later laparoscopic resection. Given the potential difficulty of detecting the lesion during laparoscopic surgery, ICG fluorescence imaging was used to determine the approximate location of the dissemination. The lesion exhibited strong fluorescence, which facilitated its complete resection.
Parthenium hysterophorus, an emergent weedy plant species expands its geographical ranges in Pakistan

Parthenium hysterophorus [commonly known as Carrot grass; native to American tropics; family Asteraceae] is a flowering, short-lived perennial or an annual invasive-weedy plant. In the recent few years, the plant is spread (in epidemic proportions) vigorously, at least, in the two provinces (KP and Punjab) and the twin capital cities (Islamabad and Rawalpindi). The weed came in the lame light soon after the monsoon rains and floods of September 2012 and August 2013 that hit larger areas of KP and Punjab provinces of Pakistan. The massive boom in the weed was witnessed in areas under floods of the river Kabul and the Indus Ocean. It is speculated that after initial entry into the flood zones, the seeds then germinated and dispersed into the near and farther areas in the country, including hilly areas. The plant is categorized as a poisonous weed, and a source of skin allergies and itching. It may be a cause of increased reports of asthma, cough, fever, and allergies related to eyes in these areas [1, 2]. Due to its vigorous growth and allelopathic effects, the plant soon dominated over all other weeds and crop plants. Furthermore, it has a tremendous potential to withstand abiotic and biotic stresses. Its vigorous growth has resulted in the loss of local floral biodiversity [3]. Specifically in Islamabad, it has dominated completely the wild cannabis (weeds). However, this year, the cannabis weed seems to overcome gradually the parthenium dominance. The coming years may witness the revival of other plant species suppressed by parthenium. Although the plant seems to be resistant/tolerant to biotic stresses, very few plants were identified with leaf rolling, vein yellowing, stunting and bunchy-top like diseases, indicative of begomovirus infection. PCR amplification and sequencing confirmed a symptomatic parthenium plant positive for the viral infection (unpublished observation; Figure 2). Previously, only a single report is available of parthenium being infected with geminiviruses [4]. Currently, no weedicide is available to eradicate the weedy plant. The only available alternative is to drag the plants out of soil along with their roots before they bear seeds. The presence of the plant everywhere on barren lands, streets, along the drains, hilly terraces, orchards, in lawn grass, and in crop fields makes complete eradication almost impossible (Figure 1a-c). Increased ailment linked with parthenium like – toxicity in the livestock and insect pollinators, skin allergies in humans and reduced agricultural productivity necessitates that the government and non-government stakeholders should take stringent measures to save human health, livestock and agricultural production.
Increasing Feasibility of Neural Network-Based Early Fault Detection in Induction Motor Drives

Modern industrial plants are complex and very sensitive to costs to the business of unscheduled downtime when a motor fails. This is the case of broken bars in induction motor (IM) drives, which still represents a large share of the market. In principle, an early defect detection is made possible by advanced artificial intelligence (AI)-based techniques, but their complexity clashes with the essential nature of IMs. This article aims to bridge the gap by using motor current signature already available in standard drives and proposing a mix of simulations and data augmentation to train efficiently the neural network (NN) without the need of many broken prototypes, which is the major flaw for the industrial feasibility.
Home and Away: The Role of Non-Coding RNA in Intracellular and Intercellular DNA Damage Response

Non-coding RNA (ncRNA) has recently emerged as a vital component of the DNA damage response (DDR), which was previously believed to be solely regulated by proteins. Many species of ncRNA can directly or indirectly influence DDR and enhance DNA repair, particularly in response to double-strand DNA breaks, which may hold therapeutic potential in the context of cancer. These include long non-coding RNA (lncRNA), microRNA, damage-induced lncRNA, DNA damage response small RNA, and DNA:RNA hybrid structures, which can be categorised as cis or trans based on the location of their synthesis relative to DNA damage sites. Mechanisms of RNA-dependent DDR include the recruitment or scaffolding of repair factors at DNA break sites, the regulation of repair factor expression, and the stabilisation of repair intermediates. DDR can also be communicated intercellularly via exosomes, leading to bystander responses in healthy neighbour cells to generate a population-wide response to damage. Many microRNA species have been directly implicated in the propagation of bystander DNA damage, autophagy, and radioresistance, which may prove significant for enhancing cancer treatment via radiotherapy. Here, we review recent developments centred around ncRNA and their contributions to intracellular and intercellular DDR mechanisms.
Sizing and Energy Management of Parking Lots of Electric Vehicles Based on Battery Storage with Wind Resources in Distribution Network

In this paper, an optimal sizing and placement framework (OSPF) is performed for electric parking lots integrated with wind turbines in a 33-bus distribution network. The total objective function is defined as minimizing the total cost including the cost of grid power, cost of power losses, cost of charge and discharge of parking lots, cost of wind turbines as well as voltage deviations reduction. In the OSPF, optimization variables are selected as electric parking size and wind turbines, which have been determined optimally using an intelligent method named arithmetic optimization algorithm (AOA) inspired by arithmetic operators in mathematics. The load following strategy (LFS) is used for energy management in the OSPF. The OSPF is evaluated in three cases of the objective function such as minimizing the cost of power losses, minimizing the network voltage deviations, and minimizing the total objective function using the AOA. The capability of the AOA is compared with the well-known particle swarm optimization (PSO) and artificial bee colony (ABC) algorithms for solving the OSPF in the last case. The findings show that the power loss, voltage deviations, and power purchased from the grid are reduced considerably based on the OSPF using the AOA. The results show the lowest total cost of energy and also minimum network voltage deviation (third case) by the AOA in comparison with the PSO and ABC with a higher convergence rate, which confirms the better capability of the proposed method. The results of the first and second cases show the high cost of power purchased from the main grid as well as the high total cost. Therefore, the comparison of different cases confirms that considering the cost index along with losses and voltage deviations causes a compromise between different objectives, and thus the cost of purchasing power from the main network is significantly reduced. Moreover, the voltage profile of the network improves, and also the minimum voltage of the network is also enhanced using the OSPF via the AOA.
ARV-825 Demonstrates Antitumor Activity in Gastric Cancer via MYC-Targets and G2M-Checkpoint Signaling Pathways

Objective Suppression of bromodomain and extra terminal (BET) proteins has a bright prospect to treat MYC-driven tumors. Bromodomain containing 4 (BRD4) is one of the BET proteins. ARV-825, consisting of a BRD4 inhibitor conjugated with a cereblon ligand using proteolysis-targeting chimera (PROTAC) technology, was proven to decrease the tumor growth effectively and continuously. Nevertheless, the efficacy and mechanisms of ARV-825 in gastric cancer are still poorly understood. Methods Cell counting kit 8 assay, lentivirus infection, Western blotting analysis, Annexin V/propidium iodide (PI) staining, RNA sequencing, a xenograft model, and immunohistochemistry were used to assess the efficacy of ARV-825 in cell level and animal model. Results The messenger RNA (mRNA) expression of BRD4 in gastric cancer raised significantly than those in normal tissues, which suggested poor outcome of patients with gastric cancer. ARV-825 displayed higher anticancer efficiency in gastric cancer cells than OTX015 and JQ1. ARV-825 could inhibit cell growth, inducing cell cycle block and apoptosis in vitro. ARV-825 induced degradation of BRD4, BRD2, BRD3, c-MYC, and polo-like kinase 1 (PLK1) proteins in four gastric cancer cell lines. In addition, cleavage of caspase 3 and poly-ADP-ribose polymerase (PARP) was elevated. Knockdown or overexpression CRBN could increase or decrease, respectively, the ARV-825 IC50 of gastric cancer cells. ARV-825 reduced MYC and PLK1 expression in gastric cancer cells. ARV-825 treatment significantly reduced tumor growth without toxic side effects and downregulated the expression of BRD4 in vivo. Conclusions High mRNA expression of BRD4 in gastric cancer indicated poor prognosis. ARV-825, a BRD4 inhibitor, could effectively suppress the growth and elevate the apoptosis of gastric cancer cells via transcription downregulation of c-MYC and PLK1. These results implied that ARV-825 could be a good therapeutic strategy to treat gastric cancer.
Examining Customer Motivation and Its Impact on Customer Engagement Behavior in Social Media: The Mediating Effect of Brand Experience

This study investigates the mediating effect of brand experience on the relationship between customer motivation and engagement behavior and conceptualizes customer motivation from the multiple dimensions of information seeking, entertainment, and social interaction. Based on 565 valid questionnaires, it analyzes the impact of customer motivation on brand experience and customer engagement behavior using SPSS and AMOS. First, customer motivation with information seeking, entertainment, and social interaction significantly impacts customer brand experience. Second, customer brand experience significantly impacts customer engagement behavior of reuse, feedback, and WOM intentions. Finally, this study explores the mediating role of customer brand experience between customer motivation and customer engagement behavior and its impact on social media. It provides a reference for social media literature research. These findings will provide insights on motivating customers to participate in social media.
Towards understanding of electrolyte degradation in lithium-mediated non-aqueous electrochemical ammonia synthesis with gas chromatography-mass spectrometry

Lithium-mediated electrochemical ammonia synthesis (LiMEAS) in non-aqueous media is a promising technique for efficient and green ammonia synthesis. Compared to the widely used Haber–Bosch process, the method reduces CO2 emissions to zero due to the application of green hydrogen. However, the non-aqueous medium encounters the alkali metal lithium and organic components at high negative potentials of electrolysis, which leads to formation of byproducts. To assess the environmental risk of this synthesis method, standardized analytical methods towards understanding of the degradation level and consequences are needed. Here we report on the implementation of an approach to analyze the liquid electrolytes after electrochemical ammonia synthesis via high-resolution gas chromatography-mass spectrometry (GCMS). To characterize the molecular species formed after electrolysis, electron ionization high-resolution mass spectrometry (EI-MS) was applied. The fragmentation patterns enabled the elucidation of the mechanisms of byproduct formation. Several organic electrolytes were analyzed and compared both qualitatively and quantitatively to ascertain molecular composition and degradation products. It was found that the organic solvent in contact with metallic electrodeposited lithium induces solvent degradation, and the extent of this decomposition to different organic molecules depends on the organic solvent used. Our results show GCMS as a suitable technique for monitoring non-aqueous electrochemical ammonia synthesis in different organic electrolytes.
Essential Oils of Melaleuca, Citrus, Cupressus, and Litsea for the Management of Infections Caused by Candida Species: A Systematic Review

Candida is a common agent of infection in humans, which has a wide distribution and is a colonizer fungus of the body, occasionally assuming the role of a pathogen. The type of treatment depends on the site of infection and the clinical condition of the patient. Superficial infections, such as mucosal infections, can be treated with topical medications. So-called alternative therapies have rarely been studied, although the literature records the effectiveness of some treatments, especially as complementary therapy. The aims of this review were to analyze evidence of the anti-Candida inhibitory activity of essential oils of the Citrus, Cupressus, Litsea, and Melaleuca species; in addition to addressing the chemical composition, probable mechanisms of antifungal action and studies of toxicity, cytotoxicity, and genotoxicity were included. The literature from Medline/PubMed, Science Direct, Scopus, Web of Science, and the Brazilian database Periodic Capes was reviewed. Thirty-eight articles were selected, which included two articles on Litsea spp. , seven on Cupressus spp. , thirteen articles on Citrus spp. , and twenty-one articles on Melaleuca spp. In conclusion, this study showed in vitro evidence for the use of essential oils of the plant species evaluated for the treatment of infections caused by different Candida species.
Recent Advances in Silicon FET Devices for Gas and Volatile Organic Compound Sensing

Highly sensitive and selective gas and volatile organic compound (VOC) sensor platforms with fast response and recovery kinetics are in high demand for environmental health monitoring, industry, and medical diagnostics. Among the various categories of gas sensors studied to date, field effect transistors (FETs) have proved to be an extremely efficient platform due to their miniaturized form factor, high sensitivity, and ultra-low power consumption. Despite the advent of various kinds of new materials, silicon (Si) still enjoys the advantages of excellent and reproducible electronic properties and compatibility with complementary metal–oxide–semiconductor (CMOS) technologies for integrated multiplexing and signal processing. This review gives an overview of the recent developments in Si FETs for gas and VOC sensing. We categorised the Si FETs into Si nanowire (NW) FETs; planar Si FETs, in which the Si channel is either a part of the silicon on insulator (SOI) or the bulk Si, as in conventional FETs; and electrostatically formed nanowire (EFN) FETs. The review begins with a brief introduction, followed by a description of the Si NW FET gas and VOC sensors. A brief description of the various fabrication strategies of Si NWs and the several functionalisation methods to improve the sensing performances of Si NWs are also provided. Although Si NW FETs have excellent sensing properties, they are far from practical realisation due to the extensive fabrication procedures involved, along with other issues that are critically assessed briefly. Then, we describe planar Si FET sensors, which are much closer to real-world implementation. Their simpler device architecture combined with excellent sensing properties enable them as an efficient platform for gas sensing. The third category, the EFN FET sensors, proved to be another potential platform for gas sensing due to their intriguing properties, which are elaborated in detail. Finally, the challenges and future opportunities for gas sensing are addressed.
L’équité en éducation et en pédagogie actualisante

The mission of the Faculté des sciences de l’éducation of the University of Moncton fits into a vision of education based on personal development, social justice and peace. In order to make this vision a reality, the faculty adopted an underlying philosophy in its teacher training activities, a global approach that it calls the Pedagogy of Actualization. For a Pedagogy
Long‐term precipitation and stream discharge records at seven forested experimental watersheds along a latitudinal transect in Japan: Jozankei, Kamabuchi, Takaragawa, Tsukuba, Tatsunokuchi‐yama, Kahoku and Sarukawa

This data note introduces a database of long‐term daily total precipitation and stream discharge data for seven forested watersheds in Japan that have been continuously monitored by the Forestry and Forest Products Research Institute. Three of the watersheds started data collection in the 1930s. Forest cover across the sites ranges from cool to warm temperate regions with the latitude spanning from 31 to 44° N and annual precipitation ranging from 1200 to 3000 mm yr−1. The effects of vegetation change via clearcutting, thinning and forest fire (among other stressors) on stream discharge can be analysed from the long‐term observation sites. Moreover, this multi‐site dataset allows for inter‐ and intra‐site comparisons of annual water loss (difference of annual precipitation and stream discharge). These long‐term datasets can provide comprehensive insights into the effects of climate change and other stressors on forested ecosystems, not only in Japan but across a spectrum of forest types, if combined with other long‐term records from other forested watersheds across the world.
The interpreter advantage in executive functions—A systematic review and meta-analysis

Given the heavy cognitive load inherent in language interpreting, interpreters may develop cognitive advantages from managing frequent switching of linguistic codes and working modes. Based on a systematic review of executive functions of inhibiting, shifting and working memory (WM) updating by Nour et al. (2020) and meta-analysis of working memory by Wen and Dong (2019) and Mellinger and Hanson (2019), this research follows the PICOS framework and the PRISMA guideline to synthesize findings from 98 tasks of 29 original studies from International and Chinese databases with a cut-off date of 1st October, 2020. Substantial evidence for an interpreter advantage in shifting was found, but not for inhibition or updating. The meta-analysis showed 1) a moderate to high effect in shifting (g = 0.68, seven WCST effects; g = -0.32, eight switching cost effects); 2) no effect in inhibiting (g = 0.13, six Stroop effects); 3) mixed effects in WM updating. Subgroup analysis on WM updating revealed significant training effects from within-group comparisons (g = 0.58, five 2-back effects; g = 0.71, two L2 listening span effects), but insignificant difference from between-group comparisons (g = -0.03 , five 2-back effects; g = 0.18, five L2 listening span effects ). More reproducible behavioral research with scientific and consistent designs is needed for a clearer understanding of the relationship between interpreting experience and EFs.