Miracle-dz/UniFAR-FTUs huggingface dataset:
Tumor risks of finerenone in patients with type 2 diabetes mellitus complicated with chronic kidney disease: a meta-analysis and systematic review of randomized controlled trials

Introduction: This study aimed to assess the tumor risk of finerenone in individuals with type 2 diabetes mellitus (T2DM) aggravated by chronic kidney disease (CKD). Methods: A thorough search in the OVID Medline, OVID EMBASE, and Cochrane Library databases from their creation through 2 November 2022 yielded randomized controlled trials (RCTs) reporting on the tumor risks of finerenone in patients with T2DM complicated with CKD. A pair of reviewers selected the relevant studies based on selection criteria, collected data, and assessed the methodological quality of eligible RCTs. The Peto odds ratio (OR) with a 95% confidence interval (CI) was calculated, and subgroup analysis of tumor nature, tumor origin system, tumor origin organ, and follow-up time was performed. Furthermore, Egger’s test was implemented to determine publication bias. Results: Four RCTs with 14,875 participants who had a low-to-moderate risk of bias were included. Compared with placebo treatment, finerenone did not increase the risk of overall neoplasms (Peto OR = 0.97; 95% CI, 0.83–1.14), malignant neoplasms (Peto OR = 1.03; 95% CI, 0.86–1.23), benign neoplasms (Peto OR = 0.94; 95% CI, 0.50–1.80), or in situ neoplasms (Peto OR = 0.14; 95% CI, 0.01–2.17). Subgroup analysis of the tumor origin system showed that finerenone was associated with an increased risk of malignant neoplasms of urinary tract compared with placebo treatment (Peto OR = 1.69; 95% CI, 1.07–2.67). The results were found to be robust in sensitivity analysis, and there was no indication of publication bias. Discussion: Finerenone is not associated with an increased risk of overall tumors, but it may be linked to an increased risk of malignant neoplasms in urinary tract. Additional well-planned cohort studies in larger research populations are needed to corroborate these findings. Systematic Review Registration: https://www.crd. york.ac. uk/prospero/display_record. php? ID=CRD42022374101, Identifier CRD42022374101.
Early results of high tibial osteotomy versus combined arthroscopic surgery

Objective To investigate the early effect of high tibial osteotomy (HTO) compared with combined arthroscopic surgery. Methods A retrospective study was conducted on patients who underwent HTO at The First Affiliated Hospital of Shandong First Medical University from January 2018 to January 2022. 138 patients (163 knees) with knee osteoarthritis (KOA) treated with HTO were selected. The medial proximal tibial angle (MPTA), joint line convergence angle (JLCA), femoral tibial angle (FTA), hip-knee-ankle (HKA) angle, weight-bearing line (WBL) ratio of the knee joint, opening gap, opening angle, American Knee Society score (KSS), US Hospital for Special Surgery (HSS) score, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score were measured to determine the different effects between HTO and HTO combined with arthroscopic by logistic regression analysis. Results Patients with HTO combined with arthroscopic surgery have improved functional scores as well as imaging perspectives compared to preoperative. By multivariate logistic analysis, it was concluded that arthroscopic surgery and gender are influential factors in the outcome of HTO surgery. The postoperative KSS score was 2.702 times more likely to be classified as excellent in the HTO combined with arthroscopy group than in the HTO group [Exp (β) = 2.702, 95% CI (1.049–6.961), P = 0.039]; the postoperative KSS score was 0.349 times more likely to be classified as excellent in women than in men [Exp (β) = 0.349, 95% CI (0.138–0.883), P = 0.026]. Conclusion Better results with HTO combined with arthroscopic surgery. HTO combined with arthroscopy is a better choice in the surgical treatment of KOA.
An Imbalanced Sequence Feature Extraction Approach for the Detection of LTE-R Cells with Degraded Communication Performance

Within the Shuo Huang Railway Company (Suning, China ) the long-term evolution for railways (LTE-R) network carries core wireless communication services for trains. The communication performance of LTE-R cells directly affects the operational safety of the trains. Therefore, this paper proposes a novel detection method for LTE-R cells with degraded communication performance. Considering that the number of LTE-R cells with degraded communication performance and that of normal cells are extremely imbalanced and that the communication performance indicator data for each cell are sequence data, we propose a feature extraction neural network structure for imbalanced sequences, based on shapelet transformation and a convolutional neural network (CNN). Then, to train the network, we set the optimization objective based on the Fisher criterion. Finally, using a two-stage training method, we obtain a neural network model that can distinguish LTE-R cells with degraded communication performance from normal cells at the feature level. Experiments on a real-world dataset show that the proposed method can realize the accurate detection of LTE-R cells with degraded communication performance and has high practical application value.
Stormwater runoff management in Sandomierz, as an example of medium-sized European city, using SCALGO Live

: European cities face urban, demographic and climate challenges. According to forecasts, annual extreme phenomena will intensify – including torrential rains. Comprehensive solutions (also those based on nature), climate adaptation strategies, runoff management, incorporation of new design (e.g. sponge cities) are urgently required in order to strengthen urban resilience and to minimise the effects of extreme weather events (droughts, floods or heat islands). The aim of the research was to develop a methodology for activating selected elements of blue-green infrastructure within areas of natural and cultural protection as an adaptive tool of urban planning. Modelling of infiltration possibilities, programmed with SCALGO Live Poland software, was performed as a case study based on a research city – Sandomierz (in Poland). Selected parameters (stormwater surface runoff, chosen runoff areas, land cover) are strongly correlated with urban indicators relating to the vegetation coverage (biologically active area – BAA). Results pointed out urban units, which BAA is lower than 25% (e.g. Old Town Square, courtyards of tenement houses). Modelling was carried out for these units by concentrating on the undeveloped area for which the BAA was increased. The enhancement assumed values in the range of 41–45%. In analysed cases, an improvement (decrease) in runoff volume was obtained, even by 8.69%. Simultaneously, infiltration increased by 19.61%, calculated over entire runoff area. Implementation of solutions based on these results, in the form of appropriate planning provisions, can raise the quality of environment (e.g. improving water infiltration) and life (e.g. more effective air cooling on hot nights).
Comparison between the Marsh Wetland Landscape Patterns in the Zoigê Plateau for Two Periods

The Zoige Wetland is one of the largest plateau wetlands in China. Since 1960s,wetlands in the Zoige Plateau have confronted the degradation crisis due to integrated influence of natural events and human activities, which have greatly changed temporal - spatial distribution pattern of wetland. Marsh wetland is the main part of the Zoige wetland,and the ratio of marsh wetland is more than 95% . In contrast,other wetland landscape com- ponents retain small proportion. Therefore,the primary aim of this paper was to study changes in landscape pat- tern of marsh wetland,including marsh and marshy meadow,in the Zoige Plateau for 2 periods over the past three decades. In this paper,to choose Zoige,Hongyuan,Aba,Maqu and Luqu counties as research area, based on Landsat MSS images in 1977 and Landsat TM images in 2007 and the 90 m resolution digital elevation model (DEM) of the study area,the comparison between landscape patterns of marsh and marshy meadow in the Zoige Plateau in 1977 and 2007 were conducted and analyzed by using RS,GIS and landscape ecology method. The results showed that the area ratio of marsh and marshy meadow ( marsh/marshy meadow) in 2007 had changed significantly relative to that in 1977,the area ratio of marsh and marshy meadow reduced from 1 /3 in 1977 to 1 /7 in 2007. To compare that in 1977,marsh wetland in the Zoige Plateau already had decreased obvi- ously in 2007 due to global climate changes and intense human interference; 61 988 hm2 marsh and 31 895 hm2 marshy meadow were lost by the end of 2007,the marsh degraded more severely than marshy meadow. During 2 periods,the marsh wetland landscape was characterized by concentrated distribution,with the aggregation degree of more than 90; the patch number of marsh wetland landscape was obviously reduced in 2007,and because of the lost marsh wetland landscape was made up of small patches,the average patch areas and aggregation in- creased. In addition,account for the marsh degraded more severely than marshy meadow lead to the diversity re- duced in 2007. In the Zoige Plateau,more than 90% of the marsh wetland distributed in the 0° - 5° slope re- gion. When the terrain slope was less than 8°,there was a significant positive correlation between the decreasing rate of marsh wetland area and the terrain slope(r = 0. 96,n = 8,p 0. 01),with the elevation of the terrain slope,the decreasing rate increased remarkably. The centroid of marsh and marshy meadow in 2007 has dis- placed relative to that in 1977. It was found that the centroid of marsh in 2007 moved towards the southwest for about 3. 88 km,and the centroid of marshy meadow moved 12. 35 km towards the northeast.
Use of nanoparticles, a modern means of drug delivery, against cryptosporidiosis

Cryptosporidium is a primary cause of waterborne epidemics, despite being previously considered only an opportunistic pathogen. The disease is associated with significant economic losses in humans and animals that are brought on by diarrhea, which frequently causes dehydration. Contact with diseased people or animals, as well as polluted water, is the major cause of infection. Different drugs are used to control the parasites. Nitazoxanide (NTZ), which is an anti-protozoan and anti-viral drug, can be used to control helminths, viruses, and protozoan parasites as a broad-spectrum antibiotic and has been approved by the food and drug authority (FDA). However, the problem is the development of resistance over a period of time in these parasites. Nanoparticles have received significant attention as possible anti-parasitic agents in recent years. By directing medications to specific cellular locations, targeted drug delivery minimizes the side effects of medications. Nanoparticles have demonstrated effectiveness against different Cryptosporidium species. Nanoparticles loaded with NTZ are found to be an effective remedy for C. parvum in young ones and decrease the oocyst count shed in the stools. Additionally, silver nanoparticles have proven to be effective against C. parvum by releasing silver ions that breach the cell wall of the oocyst, causing the escape of intracellular contents and the destruction of sporozoites within the oocyst. Implementing tiny particles for the purification of consuming water from Cryptosporidium is an economical and environmentally sustainable process. However, the use of nanoparticles in medicine requires more research.
Optimizing Cellular Network Binary Rate and Fairness: Examination of a Two-Tier Hybrid Duplex Architecture Employing Full-Duplex and Half-Duplex Modes

Full-duplex HCNs have emerged as a compelling solution to meet the escalating traffic demands of future fifth-generation networks. Theoretical advantages of full-duplex cellular networks include the potential for doubling throughput compared to half-duplex cellular systems, as base stations can both receive and transmit within the same frequency band, thereby enhancing various performance metrics. However, in practice, achieving this twofold increase in throughput and maintaining other performance metrics can be challenging due to interference from full-duplex base stations, particularly those of large-scale macro BSs. In this study, we explore a two-tier hybrid duplex HCN architecture, where small-scale BSs operate in full-duplex mode while large-scale BSs and user equipment utilize traditional half-duplex communication. This hybrid approach aims to mitigate interference issues and manage costs effectively. We investigate the impact of various network parameters, coupling scenarios, duplexing modes, and association criteria on the performance of the two-tier HCN. Our simulation results reveal the significant influence of user and small-scale BS densities, as well as the maximum user limit, on binary rate and the Jains fairness index. Remarkably, both binary rate and Jains fairness index exhibit optimal performance at specific values of cell range expansion. In the context of downlink and uplink binary rates, FD and hybrid duplex modes outperform other modes, particularly when the association criterion is based on maximizing average received power. However, when considering the Jains fairness index under the nearest association criteria, half-duplex mode consistently outperforms other modes. This research sheds light on the intricate interplay of duplexing modes, association criteria, and network parameters in the context of FD HCNs, providing valuable insights for optimizing network performance in the era of 5G and beyond.
Outpatient Treatment of Mild Dysphagia in Ear-Nose-and-Throat Clinics

Objective: Many reports on inpatient dysphagia rehabilitation in acute and convalescent rehabilitation hospitals exist, but there are a few reports on outpatient treatments. Otolaryngologists still take a trial-and-error approach when treating dysphagia. Here, we explore the effectiveness and limitations of outpatient treatment in ear-nose-and-throat (ENT) clinics. Methods: Sixty-four patients (41 males and 23 females) aged 27-101 years (mean 78 years) visited an outpatient clinic specialising in feeding and swallowing conditions (the Fukuyo ENT Clinic). All were able to perform the activities of daily living (ADL) to the extent that outpatient visits were possible; no home visits were made. The weekly outpatient day was staffed by an otolaryngologist and a speech-language-hearing therapist (SLHT). All patients were subjected to fibreoptic endoscopic evaluation of swallowing (FEES), followed by appropriate training as revealed by the examinations. Results: Salivary retention in the glottis valley and piriform sinuses improved (both p < 0.05) in 30 patients who underwent repeat FEES; we compared the initial and final figures. In 14 cases in whom maximal tongue pressure (TP) was measured, this was higher at the final than at the first examination (p < 0.01). Conclusion: Outpatient treatment at ENT clinics for patients who are able to maintain their ADLs to the extent that they are able to walk to a hospital is an option for the treatment of age-related dysphagia. For severe cases, however, house calls and collaboration with the home and nursing care sector will be necessary and should be considered in the future.
Recyclable Multimetallic High Temperature Materials for Energy Applications

Nowadays, the use of waste materials from various technologies is increasingly discussed, not only in terms of environmental impact, but especially in terms of reducing primary raw materials wherever appropriate. One such use appears to be the reuse of material by recycling and subsequent processing of selected multi-metallic high temperature materials (in this case, for example, tungsten-based alloys/composites). It is this reuse of waste as a substitute for original, relatively expensive raw materials supplied by external suppliers and the application of selected recycling technologies that will serve as a suitable alternative compared to the use of original raw materials. Selected high-temperature composite materials are, for example, part of transport containers (together with steel elements) or radiation shielding elements. These materials have specific material properties (e.g. high material density) that can be clearly exploited in the design and construction of energy components. These material properties, as well as the recycling technology of multi-metallic materials will be discussed in this presentation. Furthermore, the use of such prepared and manufactured components in a defined energy system, which is part of alternative energy sources, will be described.
31 W/mm at 8 GHz in InAlGaN/GaN HEMT With Thermal CVD SiNx Passivation

The study reports the findings on a quaternary InAlGaN/GaN high electron mobility transistor (HEMT) employing a thermal chemical vapor deposition (TCVD) silicon nitride (SiNx passivation with a record high output power density of 31.0 W/mm in the X-band. We compared the two different SiNx passivation methods, namely, TCVD deposition, and plasma-enhanced CVD (PECVD) deposition, for InAlGaN/GaN HEMTs and investigated the effects on device performance. PECVD SiNx passivation caused a considerable degradation of the two-dimensional electron gas (2DEG) mobility. However, TCVD SiNx could suppress the degradation of 2DEG mobility, resulting in a low sheet resistance of 293 ohm/sq. with a high 2DEG mobility of 2048 cm $^{{2}}\text{V}^{-{1}}\text{s}^{-{1}}$ . Furthermore, InAlGaN/GaN HEMT with TCVD SiNx passivation exhibited a high-drain current of 1230 mA/mm even after off-state stress due to the reduced current collapse and low sheet resistance. The off-state breakdown voltage increased from 169 to 227 V on using TCVD SiNx despite an increase in the maximum drain current, resulting in a high voltage of 90 V at radiofrequency. We successfully demonstrated the state-of-the-art high output power density GaN-based HEMTs with an InAlGaN barrier and TCVD SiNx passivation. Our results revealed that TCVD SiNx passivation can facilitate the application of InAlGaN/GaN HEMTs for high-power amplifiers.
Hyperalgésie induite par les opioïdes : intérêt du monitorage du tonus parasympathique chez l'homme et étude des mécanismes moléculaires de désensibilisation et de tolérance in vitro et chez la souris

L’utilisation des opioides est a l’origine de phenomenes de tolerance et d’hyperalgesie induite (HIO) aussi bien chez l’animal qu’en utilisation clinique. Ces phenomenes surviennent avec tous les opioides de maniere dose-dependante. Les mecanismes qui les sous-tendent sont complexes et imparfaitement connus. Le remifentanil et le sufentanil sont les opioides les plus utilises en France en anesthesie-reanimation. Leur utilisation s’accompagne d’une HIO qui majore la douleur postoperatoire et peut etre responsable de la persistance de la douleur a long terme. La perception des stimuli nociceptifs chez un patient sous anesthesie generale n’est pas aisee et repose encore sur des signes cliniques indirects d’activation du systeme sympathique. Ces signes peu sensibles et peu specifiques conduisent a sous doser ou sur-doser les patients en opioides. Recemment, un nouvel outil de monitorage de la nociception est apparu, l’analgesia nociception index (ANI). L’ANI reflete le tonus parasympathique et de ce fait permettrait aux anesthesistes de mieux adapter le dosage des opioides. Dans cette these, nous avons d’abord evalue la sensibilite et la specificite de l’ANI a detecter les stimuli nociceptifs, puis montre qu’elles etaient superieures a celles des signes cliniques, et superieures a d’autres indices de monitorage proposes. Ensuite nous avons valide la capacite de l’ANI a guider l’analgesie peroperatoire du remifentanil dans differentes situations.Sur le plan experimental, nous avons explore, apres une exposition courte ou prolongee a differentes doses de remifentanil et de sufentanil, les mecanismes associes a l’hyperalgesie thermique in vivo, chez la souris, et ex vivo, sur la voie des MAP kinases ERK1/2 et sur le trafic membranaire des recepteurs opioides de type µ (MOR) dans differentes cultures cellulaires. Chez la souris, nous avons mis en evidence une hyperalgesie precoce au saut sur plaque chaude, apres exposition aux doses les plus elevees de remifentanil, mais pas avec le sufentanil. De plus, nous n’avons pas observe d’HIO sur le lechage des pattes.Sur les cultures cellulaires, le remifentanil comme le sufentanil activent la voie des MAPK ERK1/2 lors d’une exposition courte, avec apparition d’une desensibilisation lorsque l’exposition se prolonge. Le remifentanil comme le sufentanil induisent une internalisation precoce et progressive des recepteurs MOR.
Roles of Y-27632 on sheep sperm metabolism

Abstract To investigate the effect of Y-27632 on low-temperature metabolism of sheep sperm, different concentrations of Y-27632 were added to sheep semen at 4 °C in this experiment to detect indicators such as sperm motility, plasma membrane, acrosome, antioxidant performance, mitochondrial membrane potential (MMP), and metabolomics. The results showed that the addition of 20 µM Y-27632 significantly increased sperm motility, plasma membrane integrity rate, acrosome integrity rate, antioxidant capacity, MMP level, significantly increased sperm adenosine triphosphate (ATP) and total cholesterol content, and significantly reduced sperm Ca2+ content. In metabolomics analysis, compared with the control group, the 20 µM Y-27632 group screened 20 differential metabolites, mainly involved in five metabolic pathways, with the most significant difference in Histidine metabolism (P = 0.001). The results confirmed that Y-27632 significantly improved the quality of sheep sperm preservation under low-temperature conditions.
Domain Mapping Network for Remote Sensing Cross-Domain Few-Shot Classification

It is a challenging task to recognize novel categories with only a few labeled remote-sensing images. Currently, meta-learning solves the problem by learning prior knowledge from another dataset where the classes are disjoint. However, the existing methods assume the training dataset comes from the same domain as the test dataset. For remote-sensing images, test datasets may come from different domains. It is impossible to collect a training dataset for each domain. Meta-learning and transfer learning are widely used to tackle the few-shot classification and the cross-domain classification, respectively. However, it is difficult to recognize novel categories from various domains with only a few images. In this article, a domain mapping network (DMN) is proposed to cope with the few-shot classification under domain shift. DMN trains an efficient few-shot classification model on the source domain and then adapts the model to the target domain. Specifically, dual autoencoders are exploited to fit the source and target domain distribution. First, DMN learns an autoencoder on the source domain to fit the source domain distribution. Then, a target autoencoder is initiated from the source domain autoencoder and further updated with a few target images. To ensure the distribution alignment, cycle-consistency losses are proposed to jointly train the source autoencoder and target autoencoder. Extensive experiments are conducted to validate the generalizable and superiority of the proposed method.