Miracle-dz/UniFAR-FTUs huggingface dataset:
Autophagic dysfunction and gut microbiota dysbiosis cause chronic immune activation in a Drosophila model of Gaucher disease

Mutations in the GBA1 gene cause the lysosomal storage disorder Gaucher disease (GD) and are the greatest known genetic risk factors for Parkinson’s disease (PD). Communication between the gut and brain and immune dysregulation are increasingly being implicated in neurodegenerative disorders such as PD. Here, we show that flies lacking the Gba1b gene, the main fly orthologue of GBA1, display widespread NF-kB signalling activation, including gut inflammation, and brain glial activation. We also demonstrate intestinal autophagic defects, gut dysfunction, and microbiome dysbiosis. Remarkably, modulating the microbiome of Gba1b knockout flies, by raising them under germ-free conditions, partially ameliorates lifespan, locomotor and immune phenotypes. Moreover, we show that modulation of the immune deficiency (IMD) pathway is detrimental to the survival of Gba1 deficient flies. We also reveal that direct stimulation of autophagy by rapamycin treatment achieves similar benefits to germ-free conditions independent of gut bacterial load. Consistent with this, we show that pharmacologically blocking autophagosomal-lysosomal fusion, mimicking the autophagy defects of Gba1 depleted cells, is sufficient to stimulate intestinal immune activation. Overall, our data elucidate a mechanism whereby an altered microbiome, coupled with defects in autophagy, drive chronic activation of NF-kB signaling in a Gba1 loss-of-function model. It also highlights that elimination of the microbiota or stimulation of autophagy to remove immune mediators, rather than prolonged immunosuppression, may represent effective therapeutic avenues for GBA1-associated disorders.
Cardiac arrest in the setting of probable catastrophic antiphospholipid syndrome in young patient with a history of COVID infection and polyglandular disorder—Case report

Antiphospholipid syndrome is an autoimmune disorder characterized by arterial and venous thrombosis and recurrent spontaneous abortions due to the persistent presence of antiphospholipid antibodies. Probable Catastrophic antiphospholipid (Catastrophic antiphospholipid-like syndrome) is a life-threatening presentation of antiphospholipid syndrome which manifests as intravascular thrombosis, leading to rapid onset of symptoms and involvement of multiple organ systems. We present a case of a 28-year-old woman with a history of polyglandular autoimmune syndrome, systemic lupus erythematosus, provoked bilateral deep vein thrombosis in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection 2 years prior, and hypothyroidism who presents with a cardiac arrest in the setting of an acute ST-elevation myocardial infarction with thromboembolic occlusion of two coronary arteries simultaneously in the setting of noncompliance with anticoagulation for the past 1 week. Her presentation was further complicated by acute hypoxic respiratory failure due to diffuse alveolar hemorrhage during the hospital course with progressive multiorgan failure and eventual death. Catastrophic antiphospholipid is associated with high morbidity and mortality, thus a timely diagnosis and multidisciplinary approach to management is needed for evaluation and management.
Nurse managers' perceptions of patient‐centred care and its influence on quality nursing care and nurse job satisfaction: Empirical research qualitative

Abstract Aim To explore nurse managers' perceptions of patient‐centered care (PCC), its influence on quality nursing care, nurse job satisfaction, and to provide baseline data for a context‐driven PCC model. Design The study utilized a qualitative, phenomenological design, employing individual in‐depth interviews to collect data on nurse managers' PCC perceptions until data saturation. Methods Sampling involved purposive selection of Northern Ghana, random selection of the tertiary hospital cluster with the three participating hospitals, and purposive sampling of the nine nurse managers. Data analysis employed thematic analysis based on a six‐phase framework. Methodological trustworthiness was ensured through various strategies including prolonged engagement, supervisor discussions and crosschecking with interviewees. Results Three main themes emerged from the study including nurse managers' conceptualization of PCC, perceived patient‐centred practices and its influence on nursing quality and job satisfaction. The findings emphasized the patient's individuality, cultural values, holistic care, the importance of strong nurse‐patient relationships and a patient‐centric environment. The nurse managers perceived PCC as positively influencing quality nursing care and nurse job satisfaction. The findings offer nuanced insights into nurse managers' perspectives on patient‐centeredness and highlight areas for improvement.
Evaluation of recombination detection methods for viral sequencing

Abstract Recombination is a key evolutionary driver in shaping novel viral populations and lineages. When unaccounted for, recombination can impact evolutionary estimations or complicate their interpretation. Therefore, identifying signals for recombination in sequencing data is a key prerequisite to further analyses. A repertoire of recombination detection methods (RDMs) have been developed over the past two decades; however, the prevalence of pandemic-scale viral sequencing data poses a computational challenge for existing methods. Here, we assessed eight RDMs: PhiPack (Profile), 3SEQ, GENECONV, recombination detection program (RDP) (OpenRDP), MaxChi (OpenRDP), Chimaera (OpenRDP), UCHIME (VSEARCH), and gmos; to determine if any are suitable for the analysis of bulk sequencing data. To test the performance and scalability of these methods, we analysed simulated viral sequencing data across a range of sequence diversities, recombination frequencies, and sample sizes. Furthermore, we provide a practical example for the analysis and validation of empirical data. We find that RDMs need to be scalable, use an analytical approach and resolution that is suitable for the intended research application, and are accurate for the properties of a given dataset (e.g. sequence diversity and estimated recombination frequency). Analysis of simulated and empirical data revealed that the assessed methods exhibited considerable trade-offs between these criteria. Overall, we provide general guidelines for the validation of recombination detection results, the benefits and shortcomings of each assessed method, and future considerations for recombination detection methods for the assessment of large-scale viral sequencing data.
Faith and Health: Psychological Perspectives

Plante, Sherman, Research on Faith and Health: New Approaches to Old Questions. Part I: Faith and Health in the General Population: Research and Theory. Thoresen, Harris, Oman, Spirituality, Religion, and Health: Evidence, Issues, and Concerns. McCullough, Religious Involvement and Mortality: Answers and More Questions. Wink, Dillon, Religious Involvement and Health Outcomes in Late Adulthood: Findings from a Longitudinal Study of Women and Men. Worthington, Berry, Parrott, Unforgiveness, Forgiveness, Religion, and Health. Sherman, Simonton, Assessment of Religiousness and Spirituality in Health Research. Part II: Faith and Health in Special Populations. Sherman, Simonton, Religious Involvement Among Cancer Patients: Associations with Adjustment and Quality of Life. Remle, Koenig, Religion and Health in HIV/AIDS Communities. Willis, Wallston, Johnson, Tobacco and Alcohol Use among Young Adults: Exploring Religious Faith, Locus of Health Control, and Coping Strategies as Predictors. Plante, Sharma, Religious Faith and Mental Health Outcomes. Part III: Faith and Health in the Clinic. Chirban, Assessing Religious and Spiritual Concerns in Psychotherapy. Tan, Dong, Spiritual Interventions in Healing and Wholeness. Shafranske, Religious Beliefs, Attitudes, and Personal and Professional Practices of Physicians and Psychologists Specializing in Rehabilitation Medicine. Part IV: Commentaries on Research Concerning Faith and Health. Sloan, Bagiella, Powell, Without a Prayer: Methodological Problems, Ethical Challenges, and Misrepresentations in the Study of Religion, Spirituality, and Medicine. Smith, Religion and Spirituality in the Science and Practice of Health Psychology: Openness, Skepticism, and the Agnosticism of Methodology. Sherman, Plante, Conclusions and Future Directions for Research on Faith and Health.
The influence of carbon on the seismic properties of solid iron

The mechanical properties of C‐doped hexagonal close‐packed (hcp) iron are studied at high pressure from first‐principles calculations. The energy required for doping with C as an interstitial impurity is 246 meV/1 wt % C at 120 GPa for one unit cell of hcp Fe and increases almost linearly with pressure. The density deficit of the inner core can be matched for 1 to 2.5 wt % in hcp Fe, depending on the thermal profile. Carbon doping in hcp iron increases the compressional seismic wave velocity, decreases the shear wave velocity, while increasing the shear wave splitting and seismic anisotropy. In general, the presence of C in the inner core helps in explaining the observed seismic properties, though it cannot be considered the only light element.
3D-printed rock models: Elastic properties and the effects of penny-shaped inclusions with fluid substitution

ABSTRACT3D printing techniques (additive manufacturing) using different materials and structures provide opportunities to understand porous or fractured materials and fluid effects on their elastic properties. We used a 3D printer (Stratasys Dimension SST 768) to print one “solid” cube model and another with penny-shaped inclusions. The 3D printing process builds materials, layer by layer, producing a slight “bedding” plane, somewhat similar to a sedimentary process. We used ultrasonic transducers (500 kHz) to measure the P- and S-wave velocities. The input printing material was thermoplastic with a density of 1.04 g/cc, P-wave velocity of 2167 m/s, and S-wave velocity of 885 m/s. The solid cube had a porosity of approximately 6% and a density of 0.98 g/cc. Its P-wave velocity was 1914 m/s in the bedding direction and 1830 m/s normal to bedding. We observed S-wave splitting with fast and slow velocities of 879 and 835 m/s, respectively. Quality factors for P- and S-waves were estimated using the sp.
The impact of tax reduction on enterprises’ financialization-A quasi-natural experiment based on the reduction of VAT rate

This study examines the influence of the reduction in value-added tax (VAT) rates in China during 2018 and 2019 on corporate financialization. By employing a difference-in-differences model and utilizing data from Chinese A-share listed companies between 2017 and 2020, we assess the effects of tax reduction policies. Moreover, it achieves this outcome through three main pathways: alleviating financing constraints, boosting fixed asset investment, and weakening corporate financial arbitrage motives. Further analysis demonstrates that the inhibitory effect of VAT rate reduction on corporate financialization is more pronounced for non-manufacturing companies, businesses reliant on the basic tax rate as their primary revenue source, companies with low intermediate input rates, and those with a strong ability to shift the tax burden. Additionally, debt financing costs play a crucial role in moderating the relationship between tax reduction policies and corporate financialization. The conclusions drawn from this study provide valuable empirical evidence that can contribute to the refinement of VAT reduction policies and the prevention and resolution of financialization at the micro-level.
Missouri Forests 2013

The third full cycle of annual inventories (2009-2013) of Missouri's forests, completed in 2013, reports that there are an estimated 15.5 million acres of forest land in the State. An estimated 60 percent of the forest land area is in sawtimber size stands, 30 percent are pole timber size, and 10 percent are seedling/sapling size or nontstocked. The net volume of live trees on forest land increased by 4 percent, from 20.1 million cubic feet in 2008, to 21.0 million cubic feet in 2013. Average annual net growth of live trees on forest land decreased by more than 25 percent, from an average of 36 cubic feet per acre in 2008, to an average of 26 cubic feet per acre in 2013. This report includes additional information on forest attributes, land-use change, carbon, and forest health. In addition to this document, Missouri Forests 2013: Statistics, Methods, and Quality Assurance is online at https://doi.org/10.2737/NRS-RB-108. It contains 1) descriptive information on methods, statistics, and quality assurance of data collection, 2) a glossary of terms, 3) tables that summarize quality assurance, 4) a core set of tabular estimates for a variety of forest resources, 5) a set of user and database guides for P2, P3, and P2+, and 6) a Microsoft Access database that represents an archive of data used in this report, with tools that allow users to produce customized estimates.
Evaluation of Trace Metals in the Sedimentsof River Bhadra near Bhadravathi town, Karnataka, India

An attempt has been made to evaluate trace metals such as Fe, Mn, Cr, Ni, Zn, Cu,, Pb, Cd. Al and Hg in the Bhadra river bed sediments from four identified stations at monthly intervals for a period of two years from March 1999 to February 2001. The results of the analysis showed that trace metals in the river bed sediments are well within the Shale standards. Trace metals in the order of their relative dominal were in the sequence Fe > Al > Mn > Zn > Pb > Cr > Cu > Ni > Cd > Hg. 58.1 and 72.2 ppm respectively.
P4HA1 expression and function in esophageal squamous cell carcinoma

This study aimed to explore the effect of P4HA1 (prolyl 4-hydroxylase subunit α1) and its ratio on the prognosis of esophageal squamous cell carcinoma. The expression data of P4HA1 in esophageal cancer in The Cancer Genome Atlas and Genotype-Tissue Expression were collected using the public database gene expression profiling interactive analysis. The expression levels of P4HA1 were examined by immunohistochemistry. The relationship between P4HA1 expression and clinicopathological parameters was analyzed the χ2 test. Survival analysis was performed to investigate the effect of P4HA1 and its ratio on prognosis. Compared with normal esophageal mucosal epithelium, there was higher P4HA1 gene mRNA in esophageal cancer tissue. Regarding the expression level, no significant difference was observed in patients with stage I–IV esophageal cancer. Immunohistochemistry showed that P4HA1 was highly expressed in esophageal squamous cell carcinoma (68.7%), while it was negatively expressed in paracancerous tissues. There was a significant difference in expression between cancer and adjacent tissues. The expression of P4HA1 associated with the degree of tumor differentiation, site, lymph node metastasis, and tumor node metastasis stage. The prognostic factors that affected the OS (overall survival) of esophageal cancer patients were the degree of differentiation, lymph node metastasis, and P4HA1 expression. Multivariate analysis of the OS results of patients showed that lymph node metastases and P4HA1 expression were independent prognostic factors that affected the OS of esophageal cancer patients. The prognostic factors affecting the PFS (progression-free survival) of esophageal cancer patients in the univariate survival analysis were as follows: degree of differentiation, lymph node metastasis, and P4HA1 expression. In addition, multivariate analysis of the PFS results of patients showed that lymph node metastasis and P4HA1 expression were independent prognostic factors that affected the PFS of esophageal cancer patients. P4HA1 may be a novel potential biomarker for the early diagnosis, prognosis, and targeted therapy of esophageal cancer.
Radiologic foot alignment and clinical outcome after percutaneous drilling for symptomatic accessory navicular in skeletally immature children

Various surgical treatments are available for a symptomatic AN, including percutaneous drilling (PD). PD is reportedly effective for ANs in skeletally immature children. However, no reports have described the foot alignment after PD in skeletally immature children. This study was performed to compare the radiographic parameters between the preoperative period and the final follow-up after PD for symptomatic ANs in skeletally immature children. From October 2013 to December 2020, PD was performed on 13 feet in 10 skeletally immature children. The patients comprised 5 boys and 5 girls with a mean age at surgery of 11.9 years. The mean follow-up period was 14.8 months. We measured 5 radiographic findings preoperatively and at the final follow-up: calcaneal pitch angle (CPA), talocalcaneal angle (TCA), talonavicular coverage angle (TNCA), anteroposterior talo-first metatarsal angle (ATMA), and lateral talo-first metatarsal angle (LTMA). Ten feet were assessed as excellent, 1 as fair, and 2 as poor. Ten unions (76.9%) were achieved among the 13 feet. The mean CPA improved from 16.4 ± 4.1 degrees preoperatively to 18.2 ± 3.4 degrees at the final follow-up, the TCA improved from 43.0 ± 3.7 to 45.2 ± 4.4 degrees, and the TNCA improved from 19.9 ± 4.4 to 15.4 ± 5.0 degrees (P < .05). The ATMA and LTMA were not significantly different between the preoperative period and final follow-up. We found that PD for symptomatic ANs in skeletally immature children was effective treatment, and some radiographic parameters showed significant differences between the preoperative period and final follow-up.
Advancing nursing practice with artificial intelligence: Enhancing preparedness for the future

Abstract Aim This article aimed to explore the role of AI in advancing nursing practice, focusing on its impact on readiness for the future. Design and Methods A position paper, the methodology comprises three key steps. First, a comprehensive literature search using specific keywords in reputable databases was conducted to gather current information on AI in nursing. Second, data extraction and synthesis from selected articles were performed. Finally, a thematic analysis identifies recurring themes to provide insights into AI's impact on future nursing practice. Results The findings highlight the transformative role of AI in advancing nursing practice and preparing nurses for the future, including enhancing nursing practice with AI, preparing nurses for the future (AI education and training) and associated, ethical considerations and challenges. AI‐enabled robotics and telehealth solutions expand the reach of nursing care, improving accessibility of healthcare services and remote monitoring capabilities of patients' health conditions.
ADC measurements with EPI scans

Poster: "ECR 2013 / C-0724 / ADC measurements with EPI scans" by: "C. Biagini1, C. Biagini2, L. Natale2, M. Betti2; 1Sesto Fiorentino (FI)/IT, 2Sesto Fiorentino/IT"
Pupil vignetting artifact on optical coherence tomography angiography

Purpose: To discuss the features of an artifact on optical coherence tomography angiography (OCTA), termed “pupil vignetting artifact,” and describe how it may masquerade as true chorioretinal pathology. Design: This was a retrospective, observational case series. Methods: The authors studied 12 eyes at a vitreoretinal clinic in Eastern India, reviewing a dark shadow such as an artifact on OCTA images. Results: In all 12 eyes, there was an appearance of a dark shadow on OCTA imaging, located at the macula, superior, superotemporal, or superonasal to the fovea, which did not correspond to any ischemic area responsible for flow-void or any media opacity casting a posterior shadow. It was believed to be an artifact caused by the vignetting effect of the pupil as the incident OCT beam clips the iris during OCTA scanning, and therefore reduces the amount of total light incident on the retina. The variability in the size, shape, and location of the artifact is contributed by a few factors such as variable angle of incident light on the pupil, pupillary dynamics, and curvature of the retinal surface. Conclusion: Pupil vignetting artifact is a unique undescribed phenomenon appearing at the macula on OCTA imaging that can masquerade as numerous true chorioretinal pathologies. This article aims to describe this artifact to avoid misinterpretation and further confusion in real-life clinical practice.
Borne Inférieure pour la Somme Coloration de Graphe via la Relaxation vers un Problème de Partition d’Entier

Soit un graphe non orienté G = (V,E), avec V = {v1, . , vn} l’ensemble des sommets et E ⊂ V × V l’ensemble des arêtes. Pour un entier k > 0, une k-coloration légale de G est l’affectation à chacun des sommets du graphe d’une des k couleurs, de telle sorte que deux sommets adjacents aient une couleur différente. Le problème de coloration de graphes (GCP) consiste à trouver une k-coloration légale, avec le plus petit nombre de couleur k possible, appelé nombre chromatique χ(G). Une des variantes du GCP est le problème de somme coloration minimale [1] (MSCP). Chaque couleur est représentée par un entier de 1 à k qui corresponds au poids de la couleur. Le MSCP consiste à trouver une k-coloration légale qui minimise non pas le nombre k de couleurs utilisées mais la somme des poids des couleurs assignées aux sommets. La valeur minimale est appelée la somme chromatique, notée Σ(G). Ce problème, pour un graphe quelconque, est NP-difficile [1]. De nombreuses approches exactes et heuristiques ont été développées au cours des dernières décennies pour trouver une borne inférieure à Σ(G). Les approches les plus efficaces connues actuellement reposent sur la notion de motif [2] d’autres sur le recouvrement du graphe en cliques [3].
Shift from transport limited to supply limited sediment concentrations with the progression of monsoon rains in the Upper Blue Nile Basin

Long‐term erosion monitoring data in the Ethiopian highlands are only available from the Soil Conservation Research Program (SCRP) watersheds including the Anjeni watershed. The 113 ha Anjeni watershed was established in 1984 and fanya juu terraces were installed in 1986. Runoff and erosion data are available from three different plot sizes and at the watershed outlet. The objective of this study was to investigate how erosion processes and sediment rating parameters vary with plot size and the progression of the rainy monsoon phase. We analyzed runoff and sediment loss data from 40 plots and the watershed outlet. The dataset included erosion data from 24 newly constructed plots (3 m length) during the rainy monsoon phase of 2012 and 2013, and 16 long‐term plots (with 12, 16, 22, and 24% slopes and 3, 15 and 30 m lengths) and the watershed outlet during the period between 1986 to 1990. Sediment concentration (C) was fitted to runoff (Q) using a power regression equation (C = aQb). Sediment concentration and yield increased with increasing plot length from 3 m to 15 m, but sediment yield decreased as plot length increased to 30 m.The coefficients (a and b) were affected by plot size and the progression of the rainy monsoon phase. As plot size increases, the a value increased, while the b value decreased. Greater a values were observed during the beginning of the monsoon phase, while values of b were greater towards the end of the monsoon phase. Overall findings suggest that erosion from cultivated fields is primarily controlled by transport limitations at the beginning of the monsoon phase, while towards the end of the monsoon phase, as surface covers emerge, sediment availability will be reduced, and thus sediment source would be a limitation. Copyright © 2016 John Wiley & Sons, Ltd.