Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of p 561 ck Deficiency on the Growth and Cytolytic Effector Function of an Interleukin-2-Dependent Cytotoxic T-Cell Line

The growth, differentiation, and functional activities of antigen-stimulated T lymphocytes are regulated by the interaction of the T-cell-derived cytokine, interleukin-2 (IL-2), with the high-affinity IL-2 receptor (IL-2R). IL-2R occupancy initiates a rapid increase in intracellular protein tyrosine phosphorylation, suggesting that a receptor-coupled protein tyrosine kinase (PTK) serves as a proximal signaling element for the IL-2R. Previous studies implicated the src-family kinase, ps6kk, as a potential IL-2R-linked signal transducer. In this study, we have characterized a spontaneous variant of the IL-2-dependent cytotoxic T-cell line, CTLL-2, which contains no detectable kck-derived mRNA transcripts, protein, or PTK activity. The p56kk-deficient CTLL-2 cells retained strict dependence on IL-2 for both viability and growth, indicating that p56kk activity was not required for the transduction of IL-2-mediated mitogenic signals. However, the p56kk-deficient cells exhibited a moderate decrease in their rate of IL-2-dependent proliferation. In contrast to this relatively modest proliferative defect, the p56kk-deficient cell line displayed a profound reduction in T-cell antigen receptordependent cytolytic effector functions. Both the proliferative and the cytolytic defects observed in the p56kk-deficient cells were completely reversed by transfection of these cells with a wild-type kk expression vector. These results indicate that p56kk expression is not obligatory for IL-2-mediated T-cell growth stimulation; however, this PTK plays a central role in the generation T-cell-mediated cytotoxic responses.
Enabling the Post-Graduate Development of Enhanced Research Methodologies and Analytical Models for Primary Research

De Montfort University’s Design Products department has recently expanded both its research activities and its taught postgraduate programmes. Whilst much of the staff’s research broadly informs the curriculum, key aspects of this output have a significant impact on the new MDes Design Products Programme and in particular the Level 6 Research for Design (RfD) Module. This 15-credit component was created to advance the students’ understanding of research methodologies through both theory and practice-based study. The module’s teaching is primarily focused on user-centred goals and has a particular emphasis on social and behavioural research, encompassing observational and interview-based studies, ethnography, user groups and trend forecasting. The module’s learning outcomes enable students to gain insights and an advanced understanding of people and behaviour that facilitates the creation of innovative and user-centred new products. This paper offers an analysis of the curriculum and the teaching strategies employed within the Research for Design Module which support students in developing enhanced research methodologies and analytical models for the examination of qualitative and quantitative research data. Key activities within the module include: (1) A seminar-based project that seeks to analyse the methods and outcomes of a departmental study which established, through ergonomic and user-centred enquiry, changes to working environments brought about by developments in technology and working practices. (2) A primary research and seminar-based project that engenders student reflection on the effectiveness of their own and their peers’ applied research and analysis strategies through the interrogation of each others’ methods, theories and conclusions.
Development of a purchasing portfolio model: an empirical study in a Brazilian hospital

Abstract This study was motivated by the complexity of managing hospital purchases. This area of activity is characterised as having a great diversity of items to be purchased, classes and suppliers, which impacts the business, costs and health risks for patients in many ways. Our paper presents the development of an approach to managing a purchasing portfolio for a large Brazilian hospital, using Kraljic’s model, the Fuzzy-TOPSIS method and decision rules as methodological resources. We discuss the results and summarise a set of managerial implications for our case study, thereby demonstrating the effectiveness of our proposal. This study also contributes to expanding the application domain of Kraljic’s model, in which the Fuzzy-TOPSIS method has proved a flexible tool, and supports solving sorting problems.
A very compact Rijndael S-box

One key step in the Advanced Encryption Standard (AES), or Rijndael, algorithm is called the “S-box”, the only nonlinear step in each round of encryption/decryption. A wide variety of implementations of AES have been proposed, for various desiderata, that effect the S-box in various ways. In particular, the most compact implementation to date of Satoh et al.[12] performs the 8-bit Galois field inversion of the S-box using subfields of 4 bits and of 2 bits. This work describes a refinement of this approach that minimizes the circuitry, and hence the chip area, required for the S-box. While Satoh[12] used polynomial bases at each level, we consider also normal bases, with arithmetic optimizations; altogether, 432 different cases were considered. The isomorphism bit matrices are fully optimized, improving on the “greedy algorithm. ” The best case reduces the number of gates in the S-box by 20%. This decrease in chip area could be important for area-limited hardware implementations, e.g., smart cards. And for applications using larger chips, this approach could allow more copies of the S-box, for parallelism and/or pipelining in non-feedback modes of AES.
IOT BASED WEARABLE WOMEN SAFETY DEVICE

Because of the increase in violence against women since recent years, women's safety has become somewhat of an issue. As of now there is no ideal solution to this problem. Previously existing apps and devices are not very effective because they need a lot of user interaction to work properly. The devices that are currently in use capture the human body temperature and heart pulse in order to trigger an alert in the occurrence of an emergency. When a person runs, every human has a different body temperature and heart/pulse rate pattern, by using a set threshold to detect an emergency situation and then triggering an alarm is not the best way, and this is where pre-existing systems fall back to produce an alarm in case of an emergency. As a result, the aim of this paper is to design a wearable women safety system that reads and gathers patterns such as body temperature and pulse rate while running. When the input readings are greater than normal, the system will automatically call and send message accordingly to several people, as well as the venue, so that help can be sent to the person who is in troublesome situation.
Vision: Explainable Hidden Mental States as Influence Indicators

We posit that the next major thrust relevant to capturing dynamics for detecting and responding to information operations is inference of hidden mental states through natural language processing and social computing techniques . An important factor contributing to this vision is the need for ex-plainable representations , e.g., propositions, to capture hidden mental states as indicators of influence campaigns. Hidden mental states under exploration include, for example, belief , stance , and concern . We view explainability not in terms of a “reason describer” for machine learning (ML) model output, but in terms of an inherently interpretable paradigm that leverages hidden mental states to produce both an explanation and a justification of output. The aim is to reap the benefits of both worlds: (1) breadth of coverage for features that are essential to the task at hand (e.g., embedding and attention models for extracting sentiment); (2) depth and transparency of representational formalisms for explaining system decisions (e.g., propositions that identify beliefs and attitudes).
RULE BASED GRID SCHEDULING IN STATIC JOB SUBMISSION ENVIRONMENT

—The grid scheduling algorithms are used for resource utilization and minimization of job completion time and waiting time. In this paper a rule based approach is presented to minimize average turnaround time in heterogeneous resource environment and static job submission environment. In static job submission environment, all the jobs are submitted at same time. Taken all jobs independent and applying the rules, the turnaround time of each job is minimized to minimize the average turnaround time of all submitted jobs.
Acceptability and Appropriateness of Digital PrEP Interventions for Black and Latina Cisgender Women: Perspectives From Service Providers in Los Angeles County

Abstract: Background: Black and Latina cisgender women (BLCW) experience disproportionately high rates of HIV infection compared with White women. BLCW also experience disparities in uptake of pre-exposure prophylaxis (PrEP), a highly effective HIV prevention strategy. Digital technology interventions may help to improve PrEP accessibility among BLCW and address barriers to receiving PrEP services in clinical settings. Methods: We conducted a formative implementation research project with service providers to explore the use of digital technology interventions to improve PrEP care continuum outcomes among priority populations in Los Angeles County. A thematic analysis approach was then used to assess the perceived acceptability and appropriateness of digital PrEP interventions for BLCW. Results: Of the five technology products presented, service providers viewed the stand-alone telemedicine platforms as the most acceptable intervention type for BLCW. Service providers also noted perceived benefits and barriers that BLCW may experience in using stand-alone telemedicine platforms, and offered recommendations for tailoring the products to meet the individual needs of BLCW. Conclusions: Digital PrEP interventions may help address barriers BLCW experience in accessing PrEP in clinical settings. We offer suggestions of implementation strategies to optimize the use of digital PrEP interventions among BLCW.
Comprehensive Process Mapping and Qualitative Interviews to Inform Implementation of Rapid Linkage to HIV Care Programs in a Mid-Sized Urban Setting in the Southern United States

Background: Rapid antiretroviral therapy (ART) initiation, in which people living with HIV start ART within days of diagnosis, is a key component of the US Ending the HIV Epidemic initiative. Setting: The Memphis Metropolitan Statistical Area ranked fourth in the United States for the highest HIV incidence per 100,000 population in 2018. Rapid ART programs are limited in the Memphis Metropolitan Statistical Area, and our objective was to identify local implementation barriers. Methods: We conducted participatory process mapping and in-depth interviews to detail steps between HIV testing at the municipal health department's Sexually Transmitted Infections Clinic and ART prescription from a nearby high-volume Ryan White–funded HIV Clinic. Results: Process mapping identified 4 modifiable, rate-limiting rapid ART barriers: (1) requiring laboratory-based confirmatory HIV results, (2) eligibility documentation requirements for Ryan White–funded services, (3) insufficient HIV Clinic medical provider availability, and (4) variability in ART initiation timing among HIV Clinic providers. Staff at both sites highlighted suboptimal communication and sense of shared management between facilities, limited resources to address important social determinants of health, and lack of Medicaid expansion in Tennessee as key barriers. In-depth interview themes negatively affecting rapid ART initiation included clinic burden; provider knowledge, attitudes, and beliefs; and client psychosocial needs. Conclusions: Our preimplementation work identified modifiable and systemic barriers to systems flow and patient-level outcomes. This work will inform the design and implementation of a locally relevant rapid ART program in Memphis, a community disproportionately affected by the HIV epidemic.
Engagement and arousal effects in predicting the increase of cognitive functioning following a neuromodulation program

Background and aim: Research in the field of Brain-Computer Interfaces (BCIs) has increased exponentially over the past few years, demonstrating their effectiveness and application in several areas. The main purpose of the present paper was to explore the relevance of user engagement during interaction with a BCI prototype (Neuro-Upper, NU), which aimed at brainwave synchronization through audio-visual entrainment, in the improvement of cognitive performance. Methods: This paper presents findings on data collected from a sample of 18 subjects with clinical disorders who completed about 55 consecutive sessions of 30 min of audio-visual stimulation. The relationship between engagement and improvement of cognitive function (measured through the Intelligence Quotient - IQ) during NU neuromodulation was evaluated through the Index of Cognitive Engagement (ICE) measured by the Pope ratio (Beta / (Alpha + Theta), and Arousal [(High Beta + Low Beta) / (High Alpha + Low Alpha)]. Results: A significant correlation between engagement and IQ improvement, but no correlation between arousal and IQ improvement emerged, as expected. Conclusions: Future research aiming at clarifying the role of arousal in psychological disorders and related symptoms will be essential. (www.actabiomedica.it)
A SINGLE-LAYER AND COMPACT CIRCULARLY POLARIZED WIDEBAND SLOT ANTENNA BASED ON ``BENT FEED''

This communication presents a novel compact and wideband circularly polarized (CP) slot antenna fed by microstrip feedline. The proposed antenna consists of a corner-truncated square-ring slot patch and a novel bent strip. The CP radiation is formed by using the bent strip to excite CP resonance modes. By intruding several open stubs to the corners of the square-ring slot patch, the impedance matching and axial ratio (AR) bandwidth are improved. The measured results show that the proposed antenna has the advantage of wideband characteristics in terms of an impedance bandwidth of 90.59% (3.2–8.5 GHz) and 3-dB axial ratio bandwidth of 84.2% (3.3–8.1 GHz). The principle as well as simulated and measured results of the proposed antenna is revealed.
DMSO_A_250699 1575..1585

Jia Zhao YaYun Wu XiangLu Rong CuiWen Zheng Jiao Guo 1Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangdong, People’s Republic of China; 2Guangdong TCM Key Laboratory for the Prevention and Treatment of Metabolic Diseases, Guangdong, People’s Republic of China; 3Joint Laboratory of Guangdong Province and Hong Kong and Macao Regions on Metabolic Diseases, Guangdong, People’s Republic of China Abstract: As an important energy reservoir, adipose tissue maintains lipid balance and regulates energy metabolism. When the body requires energy, adipocytes provide fatty acids to peripheral tissues through lipolysis. Insulin plays an important role in regulating normal fatty acid levels by inhibiting lipolysis. When the morphology of adipose tissue is abnormal, its microenvironment changes and the lipid metabolic balance is disrupted, which seriously impairs insulin sensitivity. As the most sensitive organ to respond to insulin, lipolysis levels in adipose tissue are affected by impaired insulin function, which results in serious metabolic diseases. However, the specific underlying mechanisms of this process have not yet been fully elucidated, and further study is required. The purpose of this review is to discuss the effects of adipose tissue on the anti-lipolysis process triggered by insulin under different conditions. In particular, the functional changes of this process respond to inconsonantly morphological changes of adipose tissue.
SCENE RECOGNITION WITH BAG OF WORDS

— Scene recognition is one of the key features for the development of Robotics for better understanding of the environment. The aim of this paper scene recognition is an intelligence associating with the machine. This paper will analyze the activity of scene recognition starting with very simple methods i.e. tiny images and nearest neighbor classification and then we examine techniques that resemble the state of the art, bags of quantized local features and classifying techniques like linear classifiers learned by Support Vector Machines (SVM).
Amélioration génétique de la taille de portée chez les ovins. Comparaison de méthodes de sélection

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Amélioration génétique de la taille de portée chez les ovins. Comparaison de méthodes de sélection. Miguel Perez Enciso, Jean Louis Foulley, Loys Bodin, Jean Michel Elsen, Jean Paul Poivey
Using Glasgow Coma Score at Admission to Predict One Year Mortality in Injured Admitted to the Trauma Centre of a North Indian State Lacking an Organized System of Trauma Care

Aim: To investigate whether Glasgow Coma Score at admission can be used to predict one year mortality in a resource constrained scenario lacking prehospital care. Study Design: Prospective observational study Place and Duration of Study: Study was conducted at the King George Medical University trauma centre between January 1 st , 2010 to December 31 st , 2010 Methodology: Information regarding factors known to affect mortality was recorded. Patients were Original Research Article Verma et al.; ARRB, 7(4): 241-248, 2015; Article no.ARRB. 2015.125 242 followed up till death or for a period of one year since injury. Patients that died due to reasons other than injury and those with incomplete data sets were excluded from analysis. Three patients died due to reasons other than injury. Logistic regression, actuarial survival analysis, Cox proportionate Hazard model were used to identify predictors of one year mortality. Results: We enrolled 572 patients (478 males, 94 females, mean age 40.81±16.3 years). One hundred forty three patients died during follow up (140 due to injury and 3 due to other reasons). Thirty six patients had incomplete data sets. Kaplan Meir survival curve showed two distinct phase of mortality namely before and after 6th day of injury. Mortality within six days of injury was predicted by age, ISS, APTT, Glasgow Coma Score at admission and cervical spine injury. Mortality after 6 day was predicted by Glasgow Coma Score at the time of admission. Last death occurred 8 weeks after injury. Conclusion: Glasgow coma score at the time of admission is a valid predictor of one year mortality in trauma care systems lacking in pre-hospital care and an organized system of trauma care. Patients with low Glasgow Coma Score at admission continue to die 8 weeks after injury and therefore should be managed in the hospital for at least 8 weeks.
NSS_A_330939 217..230

Purpose: Sleep is vital to cognition, yet underlying mechanisms remain unclear. Although sleep duration and continuity are two wellestablished contributors, additional factors—including homeostatic sleep drive processes—may also underlie cognition-related sleep restoration. This study investigates the relative contributions of sleep EEG factors to psychomotor functioning in adults with insomnia and healthy controls (HC) to identify the most significant sleep factors supporting psychomotor functioning. Materials and Methods: Adults with insomnia (n = 37) and HC (n = 39) completed 3 nights of polysomnography and a complex psychomotor task (switching attention task; SAT). Univariate correlations identified the most significant predictors (traditional PSG, spectral EEG, initial delta peak, and overnight delta decline) of SAT performance, which were then entered into multivariable linear regressions examining whether predictors remained significant after accounting for shortened/fragmented sleep and whether relationships differed across groups. Results: In addition to greater wake after sleep onset (WASO; r = 0.33), a slower overnight delta decline (r = 0.50) and a lower initial delta peak (r = −0.38) were the most significant predictors of poorer SAT performance. Both overnight delta decline (F(7, 68) = 12.52, p < 0.001) and initial delta peak (F(7, 68) = 7.85, p = 0.007) remained significant predictors after controlling for demographics, total sleep time, and WASO. Relationships were analogous across subject groups. Conclusion: Findings suggest that, in addition to sleep duration and continuity, processes related to recovery from and dissipation of homeostatic sleep drive may support psychomotor performance and broadly support daytime functioning in individuals with and without insomnia. Future research may examine overnight delta dynamics as transdiagnostic processes supporting cognition-related sleep restoration across a range of clinical populations.
JIC-12-2020-0365_proof 18..37

Purpose – This paper aims to analyse the roles of relational capital (RC) and knowledge management (KM) during the COVID-19 in Italian public and private hospitals, considering that intangible elements are essential during periods of uncertainty. Design/methodology/approach –Authors used a qualitative design in a case study on two Italian hospitals that have different ownership structures, which are located in the epicentre of the pandemic in Lombardy. The studywas carried out using the CAOS (“caratteristiche personali”, “ambiente”, “organizzazione” and “start-up”) model (Paoloni, 2021), which allows for comprehending and commenting on RC because of the connections between typical factors that influence an organisation. The model also allows for discussion of the use of a network and how it supports organisations. Findings – Findings of the analysis showed that during the management of the COVID-19 health emergency, ownership structure was not a discriminating factor, the created relationships were similar and they were considered in the same way. The relationships were mainly formal (except for contributions by associations or individuals) and temporary. The RC’s reactive role in overcoming crises was confirmed, and the findings indicated that this result was possible also, thanks to the KM’s role played within the organisation. Originality/value – Theoretical implications of the work are that it contributes to the sparse healthcare literature on intellectual capital (IC) and on RC and its relationships with KM. The practical implications are related to the creation of new relationships during the healthcare emergency between hospitals and the central government, which can be considered a useful lesson for the future. The theoretical implications derived from the analysis are generalisable to all organisations regardless of their type and location, as well as the practical implications are applicable to the entire national territory.