Miracle-dz/UniFAR-FTUs huggingface dataset:
Social, Behavioral, and Academic Ramifications of Video Game Playing in College

The purpose of this research project is to determine whether video game usage influences the psychological well-being of college students. This project seeks to understand technology usage habits among students and whether this affects school performance. Previous research suggests video games may be used to treat psychological issues such as anxiety. Self-report studies note video games were helpful in certain populations in coping with stress, developing positive social behaviors, and improving cognitive abilities (Carras et al., 2018; Nuyens et al., 2019; Schuurmans et al., 2018;). Since psychological well-being is a crucial factor in academic performance (Carton & Goodboy, 2015; Punia & Malaviya, 2015), the current study will examine potential relationships between gaming and college GPAs. Poor habits related to technological usage may lead to negative mental health outcomes. A survey examining these factors was completed by college students at Texas Woman’s University. The survey was composed of questions from the Internet Gaming Disorder Scale, Psychological Wellbeing Scale, and Boundary Management Subscale. Data was tested using ANOVAs, a Tukey HSD test as a post hoc test, and Eta squared. The results of the data found gaming tendencies were not significantly associated with GPA but were associated with negative mental health outcomes and increased issues with technology boundary management. The study has marked limitations due to the lack of non-gaming survey participants and most respondents identifying as female. These findings may be useful for clinicians in treating addictive gaming tendencies. Future research should examine more diverse student populations.
ACCUMULATION OF FERULIC ACID UNDER DROUGHT STRESS IN IN VITRO CULTURE OF GARDENIA JASMONIDE VARIEGATA

Gardenia is regarded as an ornamental and medicinal plant that includes important phenolic compounds,as well as some of anti-inflammatory flavonoids. The most prevalent hydroxyl cinnamic acid in plants is ferulic acid, which is 4-hydroxy-3-methoxy cinnamic acid. It demonstrates a wide range of biological activity that can be utilized as a substrate for the synthesis of chlorogenic acid. The current study aimed to evaluate the accumulation of ferulic acid and antioxidant capacity in response to ABA and PEG and mimic the draught stress, in the in vitro culture of Gardenia jasmonides Variegata. Different concentrations of abscisic acid (ABA) and polyethylene glycol (PEG) (MW: 4000–6000) were applied individually in the culture medium of Gardenia jasmonide Variegata callus cultures to evaluate their effects on the growth as well as the ferulic acid content and antioxidant capacity. The results showed that maximum values for growth indicators (fresh and dry weight) at the fourth week of culturing (9.524 and 0.446 g, respectively) with the addition of 5 g/l PEG (M.W. 6000). As for ferulic acid, PEG (M.W. 6000) at 7.5 g/l gave 2.708
The Role of Irisin throughout Women’s Life Span

Since its discovery, much attention has been drawn to irisin’s potential role in metabolic and reproductive diseases. This narrative review summarizes and updates the possible role played by this fascinating molecule in different physiological (puberty and menopause) and pathological (polycystic ovary syndrome (PCOS), functional hypothalamic amenorrhea (FHA), endometriosis, and gestational diabetes) conditions that can affect women throughout their entire lives. Irisin appears to be an important factor for the hypothalamic–pituitary–gonadal axis activation, and appears to play a role in the timing of puberty onset. Serum irisin levels have been proposed as a biomarker for predicting the future development of gestational diabetes (GDM). Its role in PCOS is still controversial, although an “irisin resistance” mechanism has been hypothesized. In addition to its impact on metabolism, irisin also appears to influence bone health. Irisin levels are inversely correlated with the prevalence of fractures in postmenopausal women. Similar mechanisms have also been postulated in young women with FHA. In clinical settings, further controlled, prospective and randomized clinical trials are needed to investigate the casual relationship between irisin levels and the conditions described and, in turn, to establish the role of irisin as a prognostic/diagnostic biomarker or a therapeutic target.
Evaluación y caracterización de una fuente de Am-241 usada como generador de partículas alfa para el análisis por emisión de rayos-X característicos

Results of an experimental evaluation on the use of an Am-241 source as generator of particles - , in X-rays fluorescence analysis of samples from a flow of charged particles (PIXE-alpha) are presented. Furthermore, the use of a material monitor (CR39) that registered the flow of radiation due to particles alpha is shown. It last optimizes the geometry sample – source -detector and the sensitivity of detection of the analytical system.
IDF-11774 Induces Cell Cycle Arrest and Apoptosis by Inhibiting HIF-1α in Gastric Cancer

Hypoxia-inducible factor-1 alpha (HIF-1α) is a regulatory factor of intracellular oxygen supersession. The expression or increased activity of HIF-1α is closely related to various human cancers. Previously, IDF-11774 was demonstrated to inhibit HSP70 chaperone activity and suppress the accumulation of HIF-1α. In this study, we aimed to determine the effects of IDF-11774 on gastric cancer cell lines. Treatment with IDF-11774 was found to markedly decrease the proliferation, migration, and invasion of the gastric cancer cell lines. Furthermore, the phosphorylation levels of extracellular signal-regulated kinase 1/2, p38, and Jun N-terminal kinase in the mitogen-activated protein kinase signaling pathways were markedly increased in a dose-dependent manner, ultimately promoting apoptosis via the induction of cell cycle arrest. Our findings indicate that HIF-1α inhibitors are potent drugs for the treatment of gastric cancer.
Slender defect segmentation network of workpiece surface based on deep learning

As a key part of the workpiece production process, workpiece surface defect segmentation detection plays an important role in the quality assurance of the workpiece. Aiming at the problem of low accuracy of workpiece surface slender defect segmentation, we propose a slender defect segmentation network based on feature enhancement module (FEM) and feature fusion module (FFM). Firstly, the ConvNeXt is improved and used as the backbone network. Then, the FEM is designed to obtain rich defect features. Finally, the FFM is designed to expand the receptive field and fuse shallow features with deep features to enhance the features of slender defects. The proposed method improves the segmentation accuracy of slender defects. The mean pixel accuracy) of slender defect segmentation on the self-built diode glass shell dataset and public magnetic sheet dataset is 97.87% and 94.86%, respectively. The mean Intersection over Union of slender defect segmentation is 94.32% and 83.89%, respectively. The segmentation speed reaches 43FPS, and the parameter is 7.12 M, which balances the segmentation accuracy, speed and model size.
Naturally Bicarbonated Water Supplementation Does Not Improve Anaerobic Cycling Performance or Blood Gas Parameters in Active Men and Women

The completion of high-intensity exercise results in robust perturbations to physiologic homeostasis, challenging the body’s natural buffering systems to mitigate the accumulation of metabolic by-products. Supplementation with bicarbonate has previously been used to offset metabolic acidosis, leading to improvements in anaerobic exercise performance. Purpose: The purpose of this study was to investigate the presence of ergogenic properties in naturally occurring low-dose bicarbonated water and their effects on anaerobic cycling performance and blood gas kinetics in recreationally active men and women. Methods: Thirty-nine healthy, recreationally active men and women (28.1 ± 8.0 years, 169.8 ± 11.7 cm, 68.9 ± 10.8 kg, 20.1 ± 7.9% fat, V˙O2peak: 42.8 ± 7.6 mL/kg/min) completed two separate testing sessions consisting of 15 cycling sprints (10 s sprint, 20 s active rest) against 7.5% of their body mass. Using a randomized, double-blind, placebo-controlled, parallel group study design, study participants consumed a 10 mL/kg dose of either spring water (SW) or bicarbonated mineral water (BMW) (delivering ~3 g/day of bicarbonate) for 7 days. Venous blood was collected before, immediately after, and 5 and 10 min after the sprint protocol and was analyzed for lactate and a series of blood gas components. After the completion of 15 cycling sprints, averages of peak and mean power for bouts 1–5, 6–10, and 11–15, along with total work for the entire cycling protocol, were calculated. All performance and blood gas parameters were analyzed using a mixed-factorial ANOVA. Results: pH was found to be significantly higher in the BMW group immediately after (7.17 ± 0.09 vs. 7.20 ± 0.11; p = 0.05) and 10 min post exercise (7.21 ± 0.11 vs. 7.24 ± 0.09; p = 0.04). A similar pattern of change was observed 5 min post exercise wherein pH levels in the SW group were lower than those observed in the BMW group; however, this difference did not achieve statistical significance (p = 0.09). A statistical trend (p = 0.06) was observed wherein lactate in the BMW group tended to be lower than in the SW group 5 min post exercise. No significant main effect for time (p > 0.05) or group × time interactions (p > 0.05) for the total work, average values of peak power, or average values of mean power were observed, indicating performance was unchanged. Conclusion: One week of consuming water with increased bicarbonate (10 mL/kg; ~3 g/day bicarbonate) showed no effect on anaerobic cycling performance. BMW decreased blood lactate concentrations 5 min after exercise and increased blood pH immediately and 10 min after exercise.
Inspiratory muscle training is effective in improving respiratory muscle functions in patients who have undergone coronary artery bypass graft

Background. Pulmonary complications are the most common cause of mortality and morbidity in post-operative populations, especially in cardiothoracic surgeries that may demand much attention from the therapist. Median sternotomy, a gold standard incision for CABG, has been shown to have an inevitable adverse effect on the performance of the respiratory muscles. Moreover, reduced blood supply to these muscles following the harvest of left internal mammary artery (LIMA) for CABG has been well acknowledged. The reduction in blood supply may lead to respiratory muscle weakness and affects recovery. In the recent past inspiratory muscle training has gained momentum as an acceptable technique in the rehabilitation of the respiratory muscles. To determine the effectiveness of inspiratory muscle training on respiratory muscle strength and endurance in patients who have undergone CABG with LIMA. Experimental study design with simple randomization Material and methods. Thirty patients who had undergone coronary artery bypass grafting with LIMA as one of the grafts were randomly divided into two groups. Postoperatively, the experimental group received inspiratory muscle training with a flow dependent trainer for 15 days exclusively along with the standard hospital protocol while the control group received only the standard physiotherapy protocol. The primary outcome measures were Maximum Inspiratory Pressure (PiMax) and Maximal Voluntary Ventilation (MVV), which are determinants of respiratory muscle strength and endurance, respectively. The variables were measured preoperatively, on the 4th day after the surgical procedure prior to training and 15 days after the training. Results. The inspiratory muscle strength and endurance in the interventional group showed significant improvement as compared to the control group. Also the MVV values in the interventional group reversed back to their presurgical levels and the improvement in the Pimax values of the experimental group was significantly higher than even the presurgical values. The control group did not display either of these two trends. Conclusions. The results of this study indicate that inspiratory muscle training is effective in improving the respiratory muscle strength and endurance in patients who have undergone coronary artery bypass graft. This study suggests that inspiratory muscle training represents a useful therapeutic adjunct in the rehabilitation protocol for patients who have undergone cardiac surgery.
The Quality of Mother–Child Feeding Interactions Predicts Psychopathological Symptoms in Offspring and Mothers Seven Years Later: A Longitudinal Study on the General Population

The increased risk of internalizing and externalizing symptoms in children has been observed in the presence of maternal psychopathology. This study aimed to investigate a potential pathway involving the quality of early interactions between mothers and their children. A sample of 150 mother–child dyads underwent assessment when the children were 3 years old and around the age of 10. Video recordings of feeding exchanges between mothers and children were analyzed to evaluate the quality of mother–child interactions. Maternal psychopathology and child internalizing and externalizing symptoms were measured through self-report and report-form measures completed by mothers. The quality of mother–child feeding interactions at three years of age significantly differentiated (p < 0.001), eight years later, between mothers at high and low psychopathological risk and between children exhibiting clinical and subclinical internalizing symptoms. Clinically relevant child symptoms were notably more prevalent when the mother–child interaction quality at three years of age was maladaptive, particularly in the context of concurrent high maternal psychopathological risk. The study findings underscore the importance of focusing on the early quality of mother–child feeding interactions to identify potential situations of maternal and child clinical risk for the development of psychopathological symptoms and to guide preemptive measures and policies.
Variations de températures estimées à partir du déplacement en altitude des associations de diatomées dans une séquence holocène de la Cordillère Orientale de Bolivie

Mean annual paleotemperatures are estimated from the altitudinal shifts of fossil diatom assemblages, compared with their present altitudinal zonation. The results suggest that temperature was close to the present one between 9,000 and 5,000 years B.P. From 5,000 years B.P., the climate was colder than present, with large amplitude oscillations
A Synthetic Model of the Mucosa for Oral Penetration Studies

The main objective of this study is the evaluation of the use of a synthetic membrane, Nuclepore, as a model for permeation studies through sublingual mucosa. The permeability of two types of membranes, porcine sublingual oral mucosa and a synthetic Nuclepore membrane, to water was compared. Moreover, the water permeability of membranes modified with waterproofing formulations was measured to study their ability to protect against the penetration of viruses, toxins, etc. A relatively high correlation (R2 0.88) was obtained between the transmucosal water loss (TMWL) values of the artificial membrane and the mucosa. These results support the possible use of this synthetic membrane in the screening of the water permeability of formulations. In addition, studies of the permeation of different actives, drugs, and biocides through the two membranes were carried out, and these results were compared with their skin permeation data. The synthetic membrane does not seem to discern between compounds in terms of permeability. However, the permeation of caffeine through intact or modified membranes incorporating waterproofing formulations presents similar permeation profiles through the synthetic membrane and mucosa. The results from these assays should lend support to the use of this synthetic membrane when screening formulations to be applied in oral penetration studies.
Preoperative Evaluation of Ovarian Tumors

Ovarian tumors involve a wide range of neoplasms, from innocuous benign tumors to aggressive cancers. Not seldom are they found by chance, without any notable symptoms, and, as cancers, they may already have metastasized at that point. The diagnostic golden standard includes vaginal ultrasound (US) along with serum biomarkers, traditionally CA125, to assess tumor characteristics. The correct preoperative diagnosis of cancer is essential, as it allows a prompt referral to a center, where the operations are performed by gynecologic oncologists. In ovarian cancer (OC), effective and correct primary surgery is the most important prognostic factor. On the other hand, conservative follow-up may be sufficient for benign tumors. Against this background, the aim of this thesis was to study advanced US modalities and to discover new possible biomarkers or methods to distinguish ovarian pathology preoperatively. First, we examined 100 at least 50-year-old women scheduled for surgery with an unclear ovarian tumor using traditional US and comparing it to various US scoring methods and three-dimensional ultrasound (3D US) with power Doppler (PD). The findings were compared with the results of examinations made by another experienced US examiner and also with histopathological diagnoses. None of the advanced US methods exceeded the accuracy of the subjective opinion of an expert. In addition, the 3D US with PD added no significant value to traditional methods. However, the results produced by two examiners were in good agreement. To extend our investigation, we collected urine samples from 71 women with indefinite adnexal masses and from 22 controls, and analyzed urinary polyamines using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Polyamines are naturally occurring components of all mammalian cells and have many functions, including cell growth. They are linked to carcinogenesis, and especially their diacetylated forms are found to be elevated in many cancers, although not previously in OC. In Study II, we showed that diacetylated spermine (DiAcSpm) was significantly elevated in urine from OC patients. While the levels of DiAcSpm differed even between low-stage OCs and benign ovarian tumors, the highest levels were found in high-grade OCs. Urinary DiAcSpm was even more sensitive than serum CA125 with its commonly used cutoff value (35 U/mL): their respective sensitivities were 86.5% and 75.7%. Based on previous experiments on the ability of dogs to detect the odor of cancer, urine samples (60 from women with adnexal tumors and 18 from controls) were also examined using field asymmetric waveform ion mobility spectrometry (FAIMS), a novel artificial olfactory technology. In our proof-of-concept Study III, we used FAIMS to differentiate between ovarian malignancy and benign tumors or controls with respective accuracies of 77.3% and 81.3%. When only high-grade cancers were taken into account, the accuracy in distinguishing them from low-grade cancers was 88.7%. Even low-grade…
Production of Cellulosic Microfibers from Coffee Pulp via Alkaline Treatment, Bleaching and Acid Hydrolysis

The present work deals with the production of cellulosic microfibers (CMFs) from coffee pulp. The experimental development corresponds to an experimental design of three variables (concentration, temperature and time) of alkaline treatment for delignification, finding that concentration, temperature and time were the most representative variables. Higher delignification was achieved by bleaching cellulosic fibers, followed by acid hydrolysis, thus producing cellulosic fibers with an average diameter of 5.2 µm, which was confirmed using scanning electron microscopy-energy-dispersive X-ray spectroscopy (SEM-EDS). An X-ray diffraction (XRD) analysis revealed, via the crystallinity index, the presence of Type I cellulose and removal of lignocellulosic compounds through chemical treatments. The proximate chemical analysis (PChA) of coffee pulp helped to identify 17% of the crude fiber corresponding to the plant cell wall consisting of lignocellulosic compounds. The initial cellulose content of 26.06% increased gradually to 48.74% with the alkaline treatment, to 57.5% with bleaching, and to 64.7% with acid hydrolysis. These results attested to the rich cellulosic content in the coffee pulp.
Connection of Optimal Stopping Time to s-t Cut Problems on Trees

We present a method to transform any optimal stopping time problem with an underlying tree structure into an s-t min-cut problem on the same tree but with modified capacities, the details of which are lacking in existing optimal stopping time research. We also show that any s-t min/max-cut problem on a tree has an equivalent optimal stopping problem formulation. We provide a dynamic programming algorithm to solve this problem and also perform a sensitivity analysis on it. Our results imply that the s-t max-cut problem on a tree can be solved using an algorithm with runtime that is linear in the tree size.
Unified Charge Control Model for Back-Gated 2-D Field Effect Transistors

A physics-based analytical dc compact model for single back-gated MoS2 field effect transistors (FETs) is presented. The model is developed by calculating the charge inside the 2-D layer which is expressed in terms of the Lambert W function that recently has become the standard in SPICE simulators. The current is then calculated in terms of the charge densities at the drain and source ends of the channel. A new mobility model is presented to account for the observed superlinear current increase above a certain gate voltage. Despite the simplicity of the model, it shows very good agreement with the experimental data as well as the possibility to be extended to model the double-gate MoS2 FETs.
A Study to Correlate AST/ALT Ratio and GGT Levels in Patients with NonAlcoholic Fatty liver Disease

1 Junior Resident, 2 Professor 1,2 Department of Biochemistry, St John’s Medical College, Bangalore *Corresponding Author Dr Swetha B John Nagar, Bangalore, India Email: swethabheema516@gmail.com Abstract Non-alcoholic fatty live disease is a condition defined by excessive fat accumulation in the form of triglycerides in the liver (> 5% of hepatocytes). There is a need for noninvasive biomarkers to detect progression of liver damage in NAFLD. As of today, limited studies exist on usage of liver enzymes as noninvasive biomarkers in NAFLD. Material & Method: This original research study included total of forty-one (41) cases and forty (40) controls were selected for the study. Patients with Ultrasound diagnosed fatty liver disease with no history of alcohol consumption referred to phlebotomy for liver function test.AST, ALT and GGT estimated by Modified IFCC with P5P method. Data analysis was done by applying R software Result: The mean value of serum AST, ALT and GGT were elevated in non-alcoholic fatty liver disease compared to controls. Serum AST/ALT ratio decreased and GGT values were increased in cases compared to controls. Independent student T test was used to analyze the data set for serum AST/ALT ratio and GGT amongst cases and the p value obtained was statistically significant. Conclusion: As increased level of liver enzymes could indicate severity of steatohepatitis and fibrosis. There is poor correlation between AST/ALT ration and GGT in NAFLD. So along with liver enzymes other noninvasive biomarkers (TNF α, IL 6, IL 8) are useful to know the extent of liver injury in NAFLD patients.