Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognostic factors and constructing a nomogram in tracheal cancer patients treated with surgical intervention: A study based on SEER database

Although surgery is considered the first choice of treatment for patients diagnosed with tracheal cancer, the prediction of overall survival (OS) in patients undergoing surgical intervention is poor. To address this issue, we developed a nomogram that combined a risk classification system to estimate the OS of patients with tracheal cancer who underwent surgical intervention. A total of 525 qualified patients were selected from the surveillance, epidemiology, and end results database between 1975 and 2018 and were randomly divided into training and validation cohorts (7:3). The parameters of independent prognostic ability were determined using Cox regression analysis, and a nomogram was formed. The predictive ability of the nomogram was tested using the area under the curve of receiver operating characteristic curves and calibration curves. Survival curves were assessed between the different risk classification groups using the Kaplan–Meier method. The results indicated that Age, stage, histology, and tumor size were independent prognostic factors and were included in the predictive model. The calibration plots demonstrated good agreement between the nomogram prediction and actual observation for 24- and 36-month OS. The receiver operating characteristic curves suggested that the predictive model had good discrimination ability, with the area under the curves (training group 0.817, 0.785, and 0.801, respectively) and validation group (0.744, 0.794, and 0.822, respectively). Furthermore, the low-risk group had a better prognosis than the high-risk group in the total, training, and validation cohorts (all P < .001). This study established a novel nomogram system to predict OS and identify independent prognostic factors in patients with tracheal cancer who underwent surgical intervention. This model has the potential to assist doctors in making decisions regarding treatment options.
Prognostic variables predict clinical outcome after decompressive craniectomy: A single institute experience; A retrospective study

Decompressive craniectomy (DC) is a well-established neurosurgical intervention in patients with high intracranial pressure who fail to respond to medical treatment. Data on predictive factors for functional outcomes in patients with DC who have malignant middle cerebral artery (MCA) infarction as opposed to intracranial hemorrhage (ICH) are scarce. Eighty-four patients who underwent DC treatment for ICH and malignant MCA infarction were examined. All patients underwent surgery in the Bahrain Salmaniya Medical Complex Neurosurgery Unit between January 2017 and June 2021. To determine whether any of these demonstrated a link to the functional outcome, radiographic factors were compared with clinical data. The postsurgical midline shift (MLS) (ICH group) showed the strongest correlation (ρ = 0.434; P = .006), as in the MCA infarction group as well (ρ = 0.46; P = .005). Further analyses using binary logistic regression with postsurgical basal cistern status and ∆ MLS, and it was observed to be statistically significant (odds ratios: 0.067, 95% CI: 0.007, 0.67; P = .021). The initial Glasgow coma scale, postsurgical MLS, basal cistern status, and ∆ are Measurable variables that can be used to predict outcomes in the groups with ICH and MCA infarction.
Hair Growth-Promoting Effects of Rosehip (Rosa canina L.) Seed Oil in C57BL/6 Mice

Rosehip (Rosa canina L.) seeds, a by-product of the food processing industry, contain various bioactive compounds that have potential cosmetic and pharmacological applications. Rosehip seed oil (RHSO) has been shown to exert therapeutic effects in skin disorders, but its role in promoting hair growth remains unknown. In this study, we aimed to elucidate the hair growth-promoting activity of RHSO and the related mechanisms of action. The depleted dorsal skin of telogenic C57BL/6 mice was topically treated with RHSO for 21 days, and the extent of hair regrowth was assessed. The results indicated that RHSO stimulated hair growth by inducing the early transition of hair follicles from telogen to anagen phase. Histological analysis revealed significant increases in hair follicle density, hair bulb size, and skin thickness. RHSO treatment also upregulated the expression of hair growth-associated genes, including β-catenin, phospho-glycogen synthase kinase-3 beta, Sonic hedgehog, smoothened, cyclin D1, cyclin E, and insulin like growth factor 1. These findings suggest that RHSO stimulates hair growth and may show promise as a preventive and/or therapeutic agent for hair loss.
The effects of mobile technology-based support on young women with depressive symptoms: A block randomized controlled trial

Background: The current body of knowledge highlights the potential role of mobile technology as a medium to deliver support for psychological and physical health. This study evaluated the influence of mobile technology support on depressive symptoms and physical activity in female university students. Methods: A block randomized controlled trial design with a single site was used. Ninety-nine participants were block-randomized into 3 arms: Experimental Group 1 (emotional and informational support group), Experimental Group 2 (informational support group), and the control group. Interventions were delivered via mobile technology for 2 weeks. Data on depressive symptoms and physical activity were collected from 84 participants at baseline and on Days 8 and 15. Data analyses included descriptive statistics, t tests, one-way analysis of variance, and repeated-measures analysis of variance. Results: This study showed no interaction effect of time and group on depressive symptom scores and physical activity, considering the emotional and informational support from mobile technology. However, Experimental Group 1 exhibited a significant reduction in depressive symptoms during the first week of the study compared to Experimental Group 2 and the control group. While physical activity in Experimental Group 2 and control group increased only during the first week of the study and subsequently decreased, Experimental Group 1 showed an initial increase during the first week that was sustained into the second week. Conclusions: Since informational and emotional support showed a strong effect over a short period of time, mobile technology offering emotional support could be used to provide crisis interventions for depression among young women when a short-term impact is required.
Effectiveness of acupuncture combined with artificial tears in managing dry eye syndrome: A systematic review and meta-analysis

Background: Dry eye syndrome is an ocular surface disease with high incidence. Acupuncture combined with artificial tears is effective for treating dry eye syndrome. This study aimed to evaluate the evidence for the efficacy of acupuncture combined with artificial tears in dry eye syndrome by conducting a systematic review and meta-analysis. Methods: A systematic online search was performed from the date of database establishment to July 1, 2023. The study groups that addressed acupuncture combined with artificial tears for patients with dry eye syndrome (DES) and the control groups that addressed artificial tears were analyzed. The main outcomes were tear breakup time (BUT) and Schirmer I test (SIT), assessed as previously described. Results: Sixteen randomized or controlled trials met the selection criteria, and 1383 patients with DES were included in this study. The analysis results showed that BUT [Standard mean difference (SMD) = 1.25, 95% confidence interval (CI) (1.14, 1.37), P < . 0001], SIT [SMD = 1.55, 95% CI (1.08, 2.02), P < . 0001], and corneal fluorescein staining [SMD = –2.08, 95% CI (–2.96, –1.20), P < . 00001] significantly improved in the trial groups compared with the control groups. The acupuncture treatment was more effective in reducing the levels of IL-6 (P < .0001) and TNF-α (P < .00001). The overall efficacy rate was better in the trial group than in the control group [odds ratio = 4.09, 95% CI (3.04, 5.51), P < . 00001]. However, no significant difference was observed in the ocular surface disease index (P = .15) between the trial and control groups. Conclusion: The results of this study indicated that acupuncture combined with artificial tears could be considered safe, effective to patients with DES.
Anemia among malaria patients with and without soil-transmitted helminths in Arba Minch town health facilities: A comparative cross-sectional study

Anemia is one of the severe clinical outcomes associated with concomitant infection of malaria and soil-transmitted helminths (STH). Since STH infections mostly share similar geographical areas with malaria, the influence of co-infections on the epidemiology and course of Anemia deserves greater consideration to assess the impact of interventions, the adequacy of strategies implemented, and the progress made in the fight against Anemia. So, this study was done to investigate Anemia among STH-negative malaria patients and malaria patients co-infected with single or multiple STHs, in 3 health facilities of Arba Minch, 2020 to 2021. An institutional-based comparative cross-sectional study was conducted at 3 Governmental Health Institutions, Arba Minch, and southern Ethiopia from November 2020 to February 2021 on a total of 321 malaria-positive study participants. Thick and thin blood films were prepared for microscopic examination of malaria parasites and identification of species. A malaria parasite count was done to determine the intensity of the infection. A stool wet mount was done to identify STHs. Kato-Katz was done for microscopic quantitative examination of STHs. A complete blood cell count was done to determine hemoglobin level. Socio-demographic data were collected using a questionnaire. Data were analyzed using SPSS version 25. Independent samples t test and one-way analysis of variance were done. Anemia magnitude in this study was 38.3% and it was higher in malaria with multiple STH co-infection groups (55.1%). Malaria parasite density was significantly higher in malaria with multiple STHs co-infected study participants F (2, 318) = 20.075. It increased with the increasing intensity of hookworm, Trichuris trichiura, and several co-infecting helminth species. But it decreased with increasing intensity of Ascaris lumbricoides. The mean hemoglobin concentration of malaria with multiple STHs co-infection study participants was significantly lower than mono malaria-infected and malaria with single STHs co-infection study participants. The management of malaria should take account of STH infections and optimal modalities of treatment should be devised. Anti-helminthic treatments of malaria patients through regular, inexpensive, single-dose, and highly effective drugs must be seriously considered to protect the population from exacerbation of Anemia by intestinal helminth infections.
Relationship between trimethylamine N-oxide and the risk of hypertension in patients with cardiovascular disease: A meta-analysis and dose-response relationship analysis

Background: The gut microbiota-dependent metabolite trimethylamine N-oxide (TMAO) has recently been recognized to be one of the risk factors for cardiovascular disease (CVD). However, there is a scarcity of data on the relationship between circulating TMAO levels and hypertension in patients with CVD. Meta analysis and a dose-response relationship were used in this study to assess the relationship between circulating trimethylamine N-oxide levels and the risk of hypertension in patients with CVD. Methods: CNKI, Wanfang Database, Pubmed, Embase, Cochrane Library, and Web of Science were searched up to June 01, 2023. Meta-analysis and dose-response analysis of relative risk data from prospective cohort studies reporting on the relationship between circulating TMAO levels and hypertension risk in patients with CVD were conducted. Results: Fifteen studies with a total of 15,498 patients were included in the present meta-analysis. Compared with a lower circulating TMAO level, a higher TMAO level was associated with a higher risk of hypertension in patients with CVD (RR = 1.14,95%CI (1.08, 1.20)). And the higher the TMAO level, the greater the risk of hypertension. The dose-response analysis revealed a linear dose-response relationship between circulating TMAO levels and the risk of hypertension in patients with CVD. The risk of hypertension increased by 1.014% when the circulating TMAO level increased by 1 μ mol/L. Conclusion: In patients with CVD, the level of circulating TMAO is significantly related to the risk of hypertension. The risk of hypertension increased by 1.014% for every 1 μ mol/L increase in circulating TMAO levels.
DEVELOPMENT AND EVALUATION OF A WEIGHABLE LYSIMETER TO DETERMINE CROP EVAPOTRANSPIRATION

The development and evaluation of a weighable lysimeter to determine crop evapotranspiration is presented. A weighable lysimeter with a diameter of 31 cm and a depth of 37 cm was constructed. The lysimeter was evaluated by using it to estimate the crop evapotranspiration of waterleaf in Umudike in Southeastern Nigeria. The evapotranspiration (ETc) estimates by Pan Evapotranspiration, Blaney – Morin Nigeria, Blaney – Criddle and Modified Hargreaves – Samani methods were compared with the estimation of the weighable lysimeter which provides the most reasonable estimation of ETc and is one of the most reliable methods. The crop was irrigated daily and the daily data generated from the lysimeter were used to calculate the crop evapotranspiration (ETc Lysimeter) between the months of July/ August, 2013. Climatic data obtained for the same period were used to determine the crop evapotranspiration (ETc) using the Pan Evapotranspiration, Blaney – Morin Nigeria, Blaney – Criddle and Modified Hargreaves – Samani methods. The total crop evapotranspiration from the Lysimeter between July and August was 141.32 mm, while that of Pan Evapotranspiration (PE), Blaney – Morin Nigeria (BMN), Blaney – Criddle (BC) and Modified Hargreaves – Samani (MHS) were 147.72 mm, 136.81 mm, 131.61 mm and 132.52 mm, respectively. Test of hypothesis using z-Test indicates that there was no significant difference between the means of the ET by lysimeter and each of the other methods (Blaney Criddle, Pan Evapotranspiration, Modified Hargreaves Samani and Blaney Morin Nigeria) for a 5% level of significance as z-cal < z-critical for the growth period of 15 July to 18 August, 2013.
A Study on Choosing Sites for Logistics Distribution Center Based on GIS Service Area Analysis

Using network analysis, GIS has played an important role in electronic navigation, logistics, electricity, communications and other fields. In the spatial scales, this article has studied the sites for logistics distribution center in Xining city, using the technology of network analysis GIS service area analysis. The results show that there are two service overlapping areas and five non-service areas of the logistics distribution center. Among them, Delingha Road is the axis across an overlapping area with Riverfront South Road, Huzhu Road, Huangzhong Road, the Public Street, Bayi Road and Wuyi Road as borderline. The overlapping area has already been filled with a large number of Logistics Distribution Centers. Due to intense competition, some logistics distribution centers should be to move into the Public Street and the East Street. The Sea Lake New District which lies in one of non-service areas will become the optimal site of logistics distribution center in the future. The method proposed in this paper breaks through previous problems of single location mechanism of logistics distribution center and can distinguish the overlapping service areas and non-service areas of logistics distribution center in spatial scales. It provides more macro-scientific guidance to the relevant studies.
Interhospital Variation in Admissions Managed With Critical Care Therapies or Invasive Hemodynamic Monitoring in Tertiary Cardiac Intensive Care Units: An Analysis From the Critical Care Cardiology Trials Network Registry

BACKGROUND: Wide interhospital variations exist in cardiovascular intensive care unit (CICU) admission practices and the use of critical care restricted therapies (CCRx), but little is known about the differences in patient acuity, CCRx utilization, and the associated outcomes within tertiary centers. METHODS: The Critical Care Cardiology Trials Network is a multicenter registry of tertiary and academic CICUs in the United States and Canada that captured consecutive admissions in 2-month periods between 2017 and 2022. This analysis included 17 843 admissions across 34 sites and compared interhospital tertiles of CCRx (eg, mechanical ventilation, mechanical circulatory support, continuous renal replacement therapy) utilization and its adjusted association with in-hospital survival using logistic regression. The Pratt index was used to quantify patient-related and institutional factors associated with CCRx variability. RESULTS: The median age of the study population was 66 (56–77) years and 37% were female. CCRx was provided to 62.2% (interhospital range of 21.3%–87.1%) of CICU patients. Admissions to CICUs with the highest tertile of CCRx utilization had a greater burden of comorbidities, had more diagnoses of ST–elevation myocardial infarction, cardiac arrest, or cardiogenic shock, and had higher Sequential Organ Failure Assessment scores. The unadjusted in-hospital mortality (median, 12.7%) was 9.6%, 11.1%, and 18.7% in low, intermediate, and high CCRx tertiles, respectively. No clinically meaningful differences in adjusted mortality were observed across tertiles when admissions were stratified by the provision of CCRx. Baseline patient-level variables and institutional differences accounted for 80% and 5.3% of the observed CCRx variability, respectively. CONCLUSIONS: In a large registry of tertiary and academic CICUs, there was a >4-fold interhospital variation in the provision of CCRx that was primarily driven by differences in patient acuity compared with institutional differences. No differences were observed in adjusted mortality between low, intermediate, and high CCRx utilization sites.
Pattern and Biodiversity of Plant Community in Water-Level-Fluctuation Zone of Pengxi River After Impoundment of Three Gorges Reservoir

After impounding to altitude of 156 m,species,spatial pattern and biodiversity of plant community in water-level-fluctuation zone of Three Gorges reservoir have significant changes.The plant community under altitude of 175 m beside the Pengxi River and its tributary Baijia Stream in Kaixian County was studied from July to September,2008.108 herb sampling quadrates along five sampling transects,three beside the Pengxi River and two beside Baijia Stream,were conducted.The results show 98 species of vascular plant belong to 38 families,29 generas.52 species of wetland plant have been investigated.Therophytes(52.0%) and cryptophyte(31.6%) are the dominant compositions of Raunkiaer's life.The plant community of study area belong to 11 associations.Floodplain annual herb zone,Xanthium sibiricum zone,Paspalum paspaloides zone and Imperata cylindrica zone disperse at the lateral side of the Pengxi River and Baijia stream from riparian to altitude of 175 m.The variation and pattern of soil water content significantly influence the distribution of plant community in water-level-fluctuation zone.There is a low herb biodiversity in water-lever fluctuation zone.
Offline Implementation and Evaluation of the Canadian Small Lake Model with the Canadian Land Surface Scheme over Western Canada

AbstractThe Canadian Small Lake Model (CSLM), version 2, was run with the Canadian Land Surface Scheme (CLASS), version 3.6. 1, in an offline regional test over western Canada. Forcing data were derived from ERA-Interim and downscaled using the fifth-generation Canadian Regional Climate Model (CRCM5). The forcing precipitation field was adjusted using monthly data from the Canadian Gridded Temperature and Precipitation Anomalies (CANGRD) observation-based dataset. The modeled surface air temperature was evaluated against CANGRD data, the modeled albedo against MODIS data, and the modeled snow water equivalent against Canadian Meteorological Centre (CMC) and Global Snow Monitoring for Climate Research (GlobSnow) data. The lake simulation itself was evaluated using the Along Track Scanning Radiometer (ATSR) Reprocessing for Climate: Lake Surface Water Temperature and Ice Cover (ARC-Lake) dataset. Summer surface lake temperatures and the lake ice formation and breakup periods were well simulated, except for s.
The Potential of Aqueous Humor Sampling in Diagnosis, Prognosis, and Treatment of Retinoblastoma

Retinoblastoma (RB) is a rare malignant tumor that arises in the developing retina in one or both eyes of children. Pathogenic variants of the RB1 tumor suppressor gene drive the majority of germline and sporadic RB tumors. Considering the risk of tumor spread, the biopsy of RB tumor tissue is contraindicated. Advancement of chemotherapy has led to preservation of more eye globes. However, this has reduced access to tumor material from enucleation specimens. Recently, liquid biopsy of aqueous humor (AH) has advanced the RB tumor- or eye-specific genetic analysis. In particular, nucleic acid analysis of AH demonstrates the genomic copy number profiles and RB1 pathogenic variants akin to that of enucleated RB eye tissue. This advance reduces the previous limitation that genetic assessment of the primary tumor could be done only after enucleation of the eye. Additionally, nucleic acid evaluation of AH allows the exploration of the genomic landscape of RB tumors at diagnosis and during and after treatment. This review explores how AH sampling and AH nucleic acid analysis in RB patients assist in diagnosis, prognosis, and comprehending the pathophysiology of RB, which will ultimately benefit individualized treatment decisions to carefully manage this ocular cancer in children.
ALGUNOS ATRIBUTOS DE LA ESTRUCTURA COMUNITARIA DE LA ICTIOFAUNA DE LA LAGUNA GRANDE DE OBISPO, GOLFO DE CARIACO, VENEZUELA

Species composition, relative abundance, diversity and community structure of fishes were studied from monthly sampling during December 1995 to November1996 in the Laguna Grande de Obispo, Gulf of Cariaco, Sucre State, Venezuela. Sampling were realised in 3 stations inside the lagoon with a small beach seine and the other 4 stations with a large beach seine. Seventy four species belonging to 33 families and 68 genera were identified of which 8 species dominated, constituting 90.43% of total catch. Mugil curema, Xenomelaniris brasiliensis, Opistonema oglinum, Atherinomorus stipes and Anchoa hepsetus were present in high abundance in the biomass. M.curema dominated the catch with large seine while X. brasiliensis, M.curema and Eucinostomus argenteus dominated the catch with small seine . Species diversity (H’) ranged from 2.968 -4.607 bits/ind and species richness of Margalef from 2.7527. 464. An inverse analysis realized on catches by small seine and based on nodal constancy and fidelity allowed to define a pattern of spatial distribution of 9 groups containing 1 to 11 species on the basis their abundance, frequency of appearance and ecological characteristics of each area. An analysis of correlation showed that the salinity, dissolved O2 and precipitation did not show any significant correlation with the ecological parameters studied but existed significant correlation with average surface water temperature (p <0,05), number of species (S), individuals (N), diversity (H’) and species richness (D). The positive correlation was found with surface temperature but no relationship with relative dominance ( D1 and D2). The CPUE in biomass did not show any significant association with temperature.