Miracle-dz/UniFAR-FTUs huggingface dataset:
Major cellular and molecular processes and clinical outcomes in bone regeneration for successful dental implantation: a systematic review

Introduction: In the context of bone regeneration, bone defects still represent a major challenge in oral and maxillofacial clinical and surgical treatment. The biomimetic design of biomaterials by simulating the natural structure and composition of bone tissue has gradually become a point of research interest due to its advantages of simplicity and efficiency. Objective: It was to carry out a systematic review on cellular and molecular processes, as well as to present the main clinical approaches of bone regeneration for dental implants. Methods: The present study followed a systematic review model, following the rules of systematic review – PRISMA. The search strategy was performed in the PubMed, Cochrane Library, Web of Science and Scopus, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results: A total of 142 articles were found. A total of 84 articles were fully evaluated and 33 were included in this study. Literary findings have shown that the lack of bone in the alveolar ridges has been a major problem in functional aesthetic recovery in patients who have suffered dentoalveolar trauma. The osteoinduction process is influenced by several factors, requiring the presence of inducers, which include β-glycerolphosphate, ascorbic acid, and dexamethasone. Mesenchymal stem cells acquire the morphology and components of osteoblastic membranes and begin to express alkaline phosphatase to deposit extracellular matrix rich in calcium and certain proteins, such as osteopontin and osteocalcin. The Bio Oss® (Geistlich) biomaterial, because it is biodegradable, biocompatible, non-toxic, and has low immunogenicity and bio stimulators, can act in the regeneration of bone tissue. Application of FRP and implant placement provides stable clinical results for severely atrophic maxilla 2-4 mm. Bovine xenograft alone and in combination with liquid FRP are both successful in achieving bone augmentation around implants and produce a small change in marginal bone level and a high implant survival rate after loading. Conclusion: Through the results of the present study, it was evidenced that the success of the dental implant is directly related to successful osseointegration.
کلونینگ و بیان پروتئین سطحی HER2 انسانی در سطح سلولهای یوکاریوتی با استفاده از تکنیکهای ترانسفکشن و ترانسداکشن بهمنظور تولید تومور در موش

Background and Objective: Breast cancer is the fifth common cause of death in the world and is considered as the leading cause of cancer related death among females. HER2 is a surface antigen which is overexpressed in 30% of breast cancer cases. The aim of this study was cloning of HER2 receptor gene in pCDNA3.1\Hygro + expression vector, expression of this protein in LL2 eukaryotic cell line and production of a breast cancer mouse model. Materials and Methods: The construct expressing HER2 gene was synthesized by RNA extraction, HER2 gene amplification and its cloning into pCDNA3.1\Hygro + vector. The accuracy of cloning was approved by sequencing. In the next step, the construct was transfected into LL2 mouse cancer cells. To establish a stable cell line, transfected LL2 cells were cultured in hygromycine enriched medium for 1 month. The resultant cells had a very low growth rate. Having repeated the process three times, 10 6 cells were eventually produced. Injection of these cells into mice led to no tumor formation. Moreover, LL2 cells transducted by HER2 containing lenti-viruse were used collaterally to form tumors. Meanwhile, 10 6 transducted LL2 cells were injected subcutaneously into C57BL/6 mice. A tumor nodule was tangible 10 to 12 days post injection. Results: The HER2 gene was successfully amplified and cloned into pcDNA3.1\Hygro + . Injection of transfected and transduced LL2 cells into mice demonstrated that only the LL2 cells transduced by the viral vector pLEX HER2 were able to express human HER2 gene stably. Conclusion: By cloning and expression of HER2 on the LL2 cells, we could produce breast cancer model in mice expressing human HER2 on cells surface.
Cancellation of noise and vibration in modular permanent-magnet wind turbine generators

The mechanisms of vibration and acoustic noise emission from modular permanent magnet induction generators differ from those of conventional machines. The structure is treated as a series of independent elastic members subject to several excitation forces at twice supply frequency. With appropriate design, the excitations caused by stator modules can mutually cancel leaving a very small residual vibration. Experimental results from laboratory tests verify the existence of the cancellation effect.
Proposed Method for Measuring Customer Orientation of Companies in Freight Transport Sector

The freight transport industry is growing rapidly. There is great interest in improving processes and operations to make them more efficient and customer friendly. Freight transport research traditionally focuses on demand modeling, mode choice, and operational optimization. In contrast, this paper addresses a new field: development of a customer-oriented measurement system for freight and logistics companies. The measurement system was developed as part of research carried out for the Swiss National Railways Cargo Division and is based on professional expertise and data from stakeholders in all parts of the logistics chain. The proposed method is an indicator-based system built on a theoretical foundation, informed with the help of a workshop with experts, and validated with real-world data. The method can be used to measure the customer focus of logistics service providers over time and thus enable them to improve and benchmark a pool of logistics companies. The proposed method can also be customized to evaluate other specific customer needs by adjusting weights and indicators within its computational structure.
MDMF: Predicting miRNA–Disease Association Based on Matrix Factorization with Disease Similarity Constraint

MicroRNAs (miRNAs) have drawn enormous attention owing to their significant roles in various biological processes, as well as in the pathogenesis of human diseases. Therefore, predicting miRNA–disease associations is a pivotal task for the early diagnosis and better understanding of disease pathogenesis. To date, numerous computational frameworks have been proposed to identify potential miRNA–disease associations without escalating the costs and time required for clinical experiments. In this regard, I propose a novel computational framework (MDMF) for identifying potential miRNA–disease associations using matrix factorization with a disease similarity constraint. To evaluate the performance of MDMF, I calculated the area under the ROC curve (AUCs) in the framework of global and local leave-one-out cross-validation (LOOCV). In conclusion, MDMF achieved reliable AUC values of 0.9147 and 0.8905 for global and local LOOCV, respectively, which was a significant improvement upon the previous methods. Additionally, case studies were conducted on two major human cancers (breast cancer and lung cancer) to validate the effectiveness of MDMF. Comprehensive experimental results demonstrate that MDMF not only discovers miRNA–disease associations efficiently but also deciphers the underlying roles of miRNAs in the pathogenesis of diseases at a system level.
Predictors of Long-Term Outcomes of Video-Laparoscopic Versus Open Surgery in Obese Patients with Colorectal Cancer: A Propensity Score Matching Study

Simple Summary Reducing invasiveness in colorectal surgery settings offers advantages, especially in patients with obesity. This study aimed to fill the exploratory window on the long-term oncological safety of the video-laparoscopic versus open colorectal surgical approach in obesity. A retrospective analysis of a surgical database of 138 colorectal cancer patients was performed by applying propensity score matching as a way to reduce selection bias. Overall survival and cancer-free survival were chosen as the primary long-term outcomes to compare open and video-laparoscopic surgical approaches, in order to enrich the body of evidence on the topic and provide greater confidence in clinical settings. Abstract Background: Minimally invasive methods in colorectal surgery offer unquestionable advantages, especially in the context of obesity. The current study addresses the lack of scientific evidence on the long-term oncologic safety of video-laparoscopic (VL) approaches in excess-weight CRC patients undergoing surgery. Methods: We retrospectively analyzed a surgical database consisting of 138 CRC patients undergoing VL (n = 87, 63%) and open CRC surgery (n = 51, 37%). To reduce selection bias, a propensity score matching was applied as a preliminary step to balance the comparison between the two surgery groups, i.e., VL and open surgery. Data from patients treated by the same surgeon were used.to minimize bias. Additional Cox regression models were run on the matched sample (N = 98) to explore the observed benefits of VL surgery in terms of overall and cancer-free survival. The nonparametric Kaplan-Meier method was used to compare the two surgical approaches and assess the likelihood of survival and cancer relapse. Results: The study sample was mostly male (N = 86, 62.3%), and VL outnumbered open surgery (63% versus 37%). Both before and after the matching, the VL-allocated group showed better overall survival (p < 0.01) with comparable cancer-free survival over more than five years of median observation time (66 months). Kaplan Meier survival probability curves corroborated the VL significant protective effect on survival (HR of 0.32; 95% CI: 0.13 to 0.81) even after adjusting for major confounding factors (age, gender, comorbidity index, BMI, tumor localization, tumor staging, tumor grading, clearance, CRM). Findings on oncologic performance by tumor relapse were comparable but lacked significance due to the small number of events observed. Conclusions: Comparing CRC surgical approaches, VL allocation showed comparable cancer-free survival but also a better performance on overall mortality than open surgery over more than five years of median observation.
Angiotensin II Inhibits Insulin Receptor Signaling in Adipose Cells

Angiotensin II (Ang II) is a critical regulator of insulin signaling in the cardiovascular system and metabolic tissues. However, in adipose cells, the regulatory role of Ang II on insulin actions remains to be elucidated. The effect of Ang II on insulin-induced insulin receptor (IR) phosphorylation, Akt activation, and glucose uptake was examined in 3T3-L1 adipocytes. In these cells, Ang II specifically inhibited insulin-stimulated IR and insulin receptor substrate-1 (IRS-1) tyrosine-phosphorylation, Akt activation, and glucose uptake in a time-dependent manner. These inhibitory actions were associated with increased phosphorylation of the IR at serine residues. Interestingly, Ang II-induced serine-phosphorylation of IRS was not detected, suggesting that Ang II-induced desensitization begins from IR regulation itself. PKC inhibition by BIM I restored the inhibitory effect of Ang II on insulin actions. We also found that Ang II promoted activation of several PKC isoforms, including PKCα/βI/βII/δ, and its association with the IR, particularly PKCβII, showed the highest interaction. Finally, we also found a similar regulatory effect of Ang II in isolated adipocytes, where insulin-induced Akt phosphorylation was inhibited by Ang II, an effect that was prevented by PKC inhibitors. These results suggest that Ang II may lead to insulin resistance through PKC activation in adipocytes.
A rapid neural network-based demand estimation for generic buildings considering the effect of soft/weak story

Abstract Recent earthquakes clarified that existing a soft/weak-story in a building could completely invert the failure mechanisms of the structure. Several studies were implemented to evaluate the potential risk subjected to the buildings under the earthquake hazard. However, these researchers discarded the effect of soft/weak-story on the demand parameters of their models. This paper presents a rapid demand estimation framework for generic buildings considering the effect of soft/weak-story. In this regard, the simplified model developed according to the HAZUS approach is rectified to apply the effect of soft/weak-story on the structural behavior of the generic buildings. Artificial neural networks are implemented to remove the required time-consuming nonlinear response history analyses from the post-earthquake actions. This research utilized a suite of 111 earthquake records, originally developed by the SAC project. These motions are uniformly scaled from to to obtain a generalized dataset with different intensities. Bayesian optimization algorithm is conducted to achieve a prediction model with optimized hyperparameters. Results clarify that the proposed method is reliable and computationally cost-effective in predicting the demand parameters of generic buildings. This framework can be used in the body of a risk assessment platform to facilitate the emergency response to the earthquake hazard.
The biopsychosocial model is lost in translation: from misrepresentation to an enactive modernization

ABSTRACT Introduction There are increasing recommendations to use the biopsychosocial model (BPSM) as a guide for musculoskeletal research and practice. However, there is a wide range of interpretations and applications of the model, many of which deviate from George Engel’s original BPSM. These deviations have led to confusion and suboptimal patient care. Objectives 1) To review Engel’s original work; 2) outline prominent BPSM interpretations and misapplications in research and practice; and 3) present an “enactive” modernization of the BPSM. Methods Critical narrative review in the context of musculoskeletal pain. Results The BPSM has been biomedicalized, fragmented, and used in reductionist ways. Two useful versions of the BPSM have been running mostly in parallel, rarely converging. The first version is a “humanistic” interpretation based on person- and relationship-centredness. The second version is a “causation” interpretation focused on multifactorial contributors to illness and health. Recently, authors have argued that a modern enactive approach to the BPSM can accommodate both interpretations. Conclusion The BPSM is often conceptualized in narrow ways and only partially implemented in clinical care. We outline how an “enactive-BPS approach” to musculoskeletal care aligns with Engel’s vision yet addresses theoretical limitations and may mitigate misapplications.
Design and Development of a Twisted String Exoskeleton Robot for the Upper Limb

Design and Development of a Twisted String Exoskeleton Robot for the Upper Limb Lei Jiang High-intensity and task-specific upper-limb treatment of active, highly repetitive movements are the effective approaches for patients with motor disorders. However, with the severe shortage of medical service in the United States and the fact that post-stroke survivors can continue to incur significant financial costs, patients often choose not to return to the hospital or clinic for complete recovery. Therefore, robot-assisted therapy can be considered as an alternative rehabilitation approach because the similar or better results as the patients who receive intensive conventional therapy offered by professional physicians. The primary objective of this study was to design and fabricate an effective mobile assistive robotic system that can provide stroke patients shoulder and elbow assistance. To reduce the size of actuators and to minimize the weight that needs to be carried by users, two sets of dual twisted-string actuators, each with 7 strands (1 neutral and 6 effective) were used to extend/contract the adopted strings to drive the rotational movements of shoulder and elbow joints through a Bowden cable mechanism. Furthermore, movements of non-disabled people were captured as templates of training trajectories to provide effective rehabilitation. The specific aims of this study included the development of a two-degree-of-freedom prototype for the elbow and shoulder joints, an adaptive robust control algorithm with cross-coupling dynamics that can compensate for both nonlinear factors of the system and asynchronization between individual actuators as well as an approach for extracting the reference trajectories for the assistive robotic from non-disabled people based on Microsoft Kinect sensor and Dynamic time warping algorithm. Finally, the data acquisition and control system of the robot was implemented by Intel Galileo and XILINX FPGA embedded system.
Pathophysiology and treatment of typical and atypical haemolytic uremic syndrome

Hemolytic uremic syndrome is a rare disease, frequently responsible for renal insufficiency in children. Recent findings have led to renewed interest in this pathology. The discovery of new gene mutations in the atypical form of HUS and the experimental data suggesting the involvement of the complement pathway in the typical form, open new perspectives for treatment. This review summarizes the current state of knowledge on both typical and atypical hemolytic uremic syndrome pathophysiology and examines new perspectives for treatment.
Semirigid vibrating rotor target model for atompolyatom reactions: Application to F+CH4→CH3+HF

The semirigid vibrating rotor target (SVRT) model for the polyatomic reaction has been applied to the reaction of F+CH4→HF+CH3. The time-dependent wave packet approach has also been used in the calculation. In the current study, reaction probability, cross-section, and rate constant are calculated for the title reaction on the modified J1 (MJ1) potential energy surface (PES). Numerical calculation shows oscillatory structures in the energy dependence of the calculated reaction probability. Those structures are generally associated with broad dynamical resonance. They are almost washed-out in the energy dependence of integral cross-sections due to summation over partial waves. The calculated rate constant is in good agreement with experimental measurement.
Development of the BAM Model for Ranking Decision Making Units

هدیکچ هدافتسا زا لدم یاه ليلحت يششوپ هداد اه هولاع رب نييعت نازيم يیاراك ،يبسن طاقن نامزاس فعض ار رد صخاش یاه فلتخم نييعت هدرك و اب هیارا نازيم بولطم ،اهنآ طخ يشم نامزاس ار هب یوس یاقترا يیاراك و هرهب یرو صخشم يم . دنك لدم زا يکی ريغ یاه نامزاس يیاراك هبساحم و درکلمع يبایزرا هنيمز رد يعاعش حلاصا نارك اب هزادنا لدم اه ( هدش BAM ) . دراد مان یدنمناوت و ایازم مغريلع لدم هك يیاه BAM اهدحاو يیاراك هبساحم رد هبتر و هسیاقم هب رداق يلو دراد یدنب يمن اراك یاهدحاو ،نآ هعسوت اب ساسا نیا رب . دشاب مانب یدیدج لدم هلاقم نیا رد SupBAM هبتر تهج یاهدحاو یدنب ميمصت یريگ هیارا م ي لدم یدربراك و مهم صاوخ ،نیا رب هولاع . دوش BAM لدم و SupBAM هیارا تابثا و هدیدرگ م ي هبتر و يیاراك يبایزرا . دوش يیاناوت يتعنص کرهش یدادعت یدنب ب یایاضق و صاوخ تحص و یداهنشيپ لدم یاه ناي يم ناشن ار هدش . دهد
Dietary copper intake and the prevalence of kidney stones among adult in the United States: A propensity score matching study

Background Trace metals are essential trace elements for the human body, but insufficient or excessive levels of metal ions can lead to the development of disease. The purpose of this study was to examine the relationship between dietary intake of copper and the prevalence of kidney stones in U.S. adult population. Methods We included data on dietary intake of trace metals from 28,623 adult participants in the National Health and Nutrition Examination Survey (NHANES) database between 2007 and 2018. Multivariate logistic regression and restricted cubic spline (RCS) dose-response curves were used to explore the association between trace metals and kidney stones, and 1:1 propensity score matching (PSM) was performed between the stone formers and non-stone formers to test the validity of the results. Results Dose-response curves showed a non-linear negative association between dietary copper intake and kidney stones, and an increase in copper intake reduced the risk of kidney stones. Multivariate logistic regression analysis showed that the odds ratio (95% confidence interval) for kidney stones in each quartile of copper intake compared to the lowest quartile were 0.905 (0.808–1.011, p = 0.075), 0.880 (0.785–0.987, p = 0.028) and 0.853 (0.756–0.959, p = 0.009). In addition, similar conclusions were reached after analysis of PSM in the stone formers and non-stone formers groups. Conclusion Dietary copper intake was negatively and non-linearly correlated with kidney stones, which is worthy of further research and application in clinical practice.
Seamless exploitation of cell-phone antennas for near-field WPT by a frequency-diplexing approach

This paper introduces a novel solution for portable devices to exploit their existing communication antennas for bi-directional near-field wireless re-charging, without compromising their far-field properties. To demonstrate the concept, the radio-frequencies (RF) 900/1800 MHz and 433 MHz are adopted for the far-field communication and for the near-field wireless recharging, respectively. First, a pair of faced, dual-band, printed monopoles is characterized as a two-port network over the bands of interest at several distances. Then, each antenna is fed by a frequency-selective three-port network, designed to simultaneously ensure data communication at the higher frequencies and wireless re-charging at the lower one. In this way, the combined far-field and near-field operations of the resulting four-port network can be optimized. A proof-of-concept prototype has been characterized, showing ports isolation higher than 20 dB and RF-to-RF power transfer efficiency between 15% and 40% for variable faced antennas distance. When a rectifier is connected to the receiving power port, the measured RF-to-dc link efficiency varies between 9% and 20%, with portable devices located 1 and 2 centimeters apart, and the transmitted power is 10 dBm. The simultaneous high frequency communication is verified with slightly reduced performance.
Control System Development Experience for Aero Gas Turbine Demonstrator Engines

The unique development project requirements of a gas turbine engine (GTE) dictated the concurrent design, development and integration of the control system and the GTE. Valuable development experience was obtained from testing of various engine configurations. Subsequently, this enabled a prescription of system requirements for a flight worthy full authority digital electronic control (FADEC) system. This approach had to meet the mandatory requirements of independent verification and validation (IV and V) of control system that were laid down for military engine applications. The FADEC system was successfully configured, developed and integrated with the gas turbine engine on this basis.