Miracle-dz/UniFAR-FTUs huggingface dataset:
Fitting models to inadequate data by enforcing spatial and temporal smoothness

When observations are too sparse to determine the state of a dynamical model, it is necessary to make use of prior knowledge or prejudice. The approach discussed here is to require that the model state be the best smooth fit to the sparse data. The requirement of smoothness is enforced by introducing bogus data, which correspond to hypothetical observations that properties such as slope, curvature, or temporal tendency of model fields have zero values within some specified accuracy. The bogus data serve to increase the effective ratio of data to model degrees of freedom. The concept of bogus data allows a bias toward smoothness to be incorporated easily into the adjoint method for fitting time-dependent models to asynoptic data. Computational examples using a simple three-wave model show that reasonable fits can be obtained even when the number of real data is considerably less than the number of model degrees of freedom.
Geological Perspectives of Global Climate Change: Introduction and Overview*

Global climate has varied since the most primitive atmosphere developed on earth billions of years ago. This variation in climate has occurred on all timescales and has been continuous. The sedimentary rock record reflects numerous sea-level changes, atmospheric compositional changes, and temperature changes, all of which attest to climatic variation. Such evidence, as well as direct historical observations, clearly shows that temperature swings occur in both directions. Past climates have varied from those that create continental glaciers to those that yield global greenhouse conditions. Many people do not comprehend that this means their living climate also varies--it gets warmer or cooler--but typically does not remain the same for extended periods of time. Human history shows us that in general, warmer conditions have been beneficial, and colder conditions have been less kind to society (Lamb, 1995). We currently are living in a not-yet-completed interglacial stage, and it is very likely that warmer conditions lie ahead for humanity, with or without any human interference. Interglacial stages appear to last for about 11,000 years, but with large individual variability. We have been in this interglacial for about 10,000 years.
An exploration of secondary trauma effects in members of the Victoria Police Force

The purpose of the current study was to thoroughly examine the phenomenon of secondary traumatic stress (STS). STS is said to mirror the symptomatology of PTSD, such as intrusive thoughts, nightmares, and avoidance, and develops in professionals who assist and counsel the traumatised (Figley, 1995a). Prominent risk factors for the development of STS are said to include having one’s own prior trauma history, dealing with victims of sexual abuse and working with traumatized children (Beaton & Murphy, 1995; Cunningham, 2003; Figley, 1995a), with the necessary conduit for STS development being empathic concern (Figley, 1995a). The current study investigated if secondary trauma could be determined in Victoria Police members and particularly in police officers working in sexual offences and child abuse units (SOCAU). Participants were 210 police officers (135 men and 75 women) with ages ranging from 20 to 55 years (men M = 41.5 years, SD = 6.9; women, M = 36.8, SD = 7.04). The current results revealed that there was strong convergence between scores on the Secondary Traumatic Stress Scale (STSS; Bride, Robinson, Yegidis & Figley, 2004) and scores on the measure of Emotional Exhaustion (a subscale within the Maslach Burnout Inventory; Maslach & Jackson, 1986). Furthermore, none of the main theoretical antecedents (proposed by Figley, 1995a) predicted the development of STS and multiple regressions revealed that the same five variables (Alcohol Use, less Emotional Stability, lack of Social Support, Denial, and Turnover Intent) predicted both STS and Emotional Exhaustion to the same degree (accounting for 51% of the variance in each construct). The predictors themselves are not trauma specific, and have been studied extensively in the burnout literature. The
An adolescent female African elephant (Loxodonta africana) gave birth to an abnormal calf

Abstract Maternal nutrition and the uterine environment can influence placental development in mammals, leading to the birth of abnormal infants who often experience difficulties in independent standing. This article documents an adolescent female African elephant (Loxodonta africana) giving birth to an African elephant calf with a shoulder height below the mean, and its inability to stand for the first 10 h after birth, a time span that significantly exceeds the average duration for independent standing. Through the implementation of assisted feeding and assisted standing measures, the calf eventually achieved independent standing and nursing from its mother after 27 h and subsequent catch‐up growth at 5 months of age. This study presents the first case report on the growth parameters during pregnancy of an adolescent African elephant, the birth and care (feeding, assisted standing) of a small African elephant calf with the inability to stand alone and nurse independently for several hours, highlighting pregnancy may influence the growth of cows during their ongoing growth and development phase, the calf's survival and subsequent catch‐up growth at 5 months of age. These findings offer valuable insights into the care of abnormal African elephant calves.
Managed relocation: an assessment of its feasibility as a coastal management option

Managed relocation is explained and examined as an option to add to the usual categories considered in relation to managing coastal erosion. The paper considers the relocation of buildings in one unit, as opposed to demolition and re-construction. The standard coastal erosion management options are briefly noted and how managed relocation can fit into these options is explained. This paper focuses on four case studies. Two examples are from the USA and two from the UK; of these, two (one in each of the UK and USA) took place during the nineteenth century. Managed relocation is proposed as being feasible in particular cases, particularly where there are isolated historic or high value buildings.
Study of Sediment Quality at Dredged Hollow Places in Port of Han-nan, Osaka Bay

Laboratory experiments in sediment quality at the hollow places are carried out in the presenting paper. They are designed to have the correct information of sediment in hollow area and to clarify the influence of the sediment on water quality in coastal areas. The sediment qualities in the hollows are much worse than those outside of the hollows, so that the rate of oxygen consumption by the bottom sediment in the hollows is as 2-10 times as that outside of the hollows.The formation rate of inorganic phosphorus and nitrogen in the sea mud and the diffusion rate of inorganic phosphorus and nitrogen to seawater in the hollows are much higher than those outside of hollows. These rates are different between sediments in two hollow places because of sulfide form.
Do normative data specific to Greek Australian older adults improve validity of neuropsychological assessment results?

Abstract Objective: This study aimed to compare Greek Australian and English language normative data with regard to impairment rates yielded within a healthy Greek Australian older adult sample. We also examined whether optimal cut scores could be identified and capable of sensitively and specifically distinguishing between healthy Greek Australians from those with a diagnosis of Alzheimer’s disease (AD). Method: Ninety healthy Greek Australian older adults and 20 demographically matched individuals with a diagnosis of AD completed a range of neuropsychological measures, including the Wechsler Adult Intelligence Scale-Fourth Edition, Greek Adaptation (WAIS-IV GR), verbal and visual memory, language and naming, and executive functions. Impairment rates derived from the use of either Greek Australian or English language normative data were calculated and compared, using a 1.5 standard deviation criterion to denote impairment. Receiver operating characteristics curve analysis was used to investigate the sensitivity and specificity of alternate cut scores. Results: Impairment rates derived from the Greek Australian normative data showed that rates of impairment generally fell within the expected 7% range. In contrast, impairment rates for all tests derived using English language normative data were significantly higher and ranged from 11%–66%. Comparisons between healthy and AD participants with moderate dementia showed significant differences across all measures. Area under the curve results ranged from . 721 to . 999 across all measures, with most tests displaying excellent sensitivity and specificity. Conclusions: English language normative data were found to be inappropriate for use with Greek Australian elders, potentially leading to erroneous diagnostic outcomes. The use of minority group specific normative data and associated cut points appear to partially ameliorate this issue. Clinical implications are discussed alongside future research directions.
MicroRNA-221-3p promotes post-burn HUVEC proliferation, migration, and angiogenesis by regulating CDKN1B.

BACKGROUND AND OBJECTIVE Previous studies have shown that miR-221-3p plays an important role in vascular remodeling, but it is unclear whether it contributes to angiogenesis after burn injury. The purpose of this study was to investigate the effect of miR-221-3p on angiogenesis in HUVECs after burn injury and to reveal its underlying molecular mechanism. METHODS The burn HUVECs model was established by heat treatment. Plasmid or oligonucleotide transfection altered the expression of miR-221-3p and CDKN1B in HUVECs. MTT, colony formation, Transwell, flow cytometry, and tube formation experiments were applied to assess the proliferation, migration, apoptosis, cell cycle, and tube formation capacity of HUVECs. miR-221-3p, CDKN1B, Ki-67, and PCNA expression was assessed by RT-qPCR or Western blot. The dual-luciferase reporter assay verified the targeting relationship between miR-221-3p and CDKN1B. RESULTS miR-221-3p was lowly expressed and CDKN1B was highly expressed in burn HUVECs. Overexpression of miR-221-3p promoted the proliferation, migration, and tube formation ability of burn HUVECs and inhibited apoptosis and the proportion of cells in the G0/G1 phase, whereas overexpression of CDKN1B had the opposite effect. Knockdown of miR-221-3p further inhibited the angiogenic capacity of burn HUVECs, but this effect was reversed by knockdown of CDKN1B. Mechanistically, miR-221-3p targeted CDKN1B. CONCLUSION miR-221-3p improves the angiogenesis of burn HUVECs by targeting CDKN1B expression, and the miR-221-3p/CDKN1B axis may serve as a potential molecular target for future burn therapy.
Arc magmatism in eastern Kumaun Himalaya, India: A study based on geochemistry of granitoid rocks

Petrochemical studies of granitoid rocks from the eastern part of Kumaun region suggest that the leading edge of India represents an active arc during Late Paleoproterozoic times. It has been observed that melt generation for granodiorite rocks from the eastern Almora Nappe and Chhiplakot klippe along with the Askot klippe was caused through a subduction‐related process involving hydrous partial melting of a Paleoproterozoic amphibole‐ and/or garnet‐bearing mafic source with the involvement of sediments from the subduction zone. The medium‐ to high‐K basic rocks, common in subduction‐related magmatic arcs, can also explain the generation of the high‐K granodiorites of the Chhiplakot klippe. The augen gneisses from the eastern Almora nappe and Chhiplakot klippe along with the Askot klippe further show geochemical similarity with the associated granodiorites, suggesting there is a genetic linkage with one another.
AtIAR1 is a Zn transporter that regulates auxin metabolism in Arabidopsis thaliana

Abstract Root growth in Arabidopsis is inhibited by exogenous auxin–amino acid conjugates, and mutants resistant to one such conjugate [indole-3-acetic acid (IAA)–Ala] map to a gene (AtIAR1) that is a member of a metal transporter family. Here, we test the hypothesis that AtIAR1 controls the hydrolysis of stored conjugated auxin to free auxin through zinc transport. AtIAR1 complements a yeast mutant sensitive to zinc, but not manganese- or iron-sensitive mutants, and the transporter is predicted to be localized to the endoplasmic reticulum/Golgi in plants. A previously identified Atiar1 mutant and a non-expressed T-DNA mutant both exhibit altered auxin metabolism, including decreased IAA–glucose conjugate levels in zinc-deficient conditions and insensitivity to the growth effect of exogenous IAA–Ala conjugates. At a high concentration of zinc, wild-type plants show a novel enhanced response to root growth inhibition by exogenous IAA–Ala which is disrupted in both Atiar1 mutants. Furthermore, both Atiar1 mutants show changes in auxin-related phenotypes, including lateral root density and hypocotyl length. The findings therefore suggest a role for AtIAR1 in controlling zinc release from the secretory system, where zinc homeostasis plays a key role in regulation of auxin metabolism and plant growth regulation.
Global Trends and Prospects Regarding Exosomes in Cancer Immunology Research Over the Past 10 Years

Background: Exosomes and cancer immunology are both important areas of research for cancer treatment. As much effort has been made to explore the relationship between exosomes and cancer immunology, exosomes in cancer immunology have become a hotspot in medical research. Methods: We retrieved all relevant publications between 2011 and 2021 from the Web of Science and utilized Microsoft Excel 365, Citespace, Online Analysis Platform of Literature Metrology (http://bibliometric.com/) and software including VOS viewer to analyze and visualize the research result. Results: Of the 820 studies included, China published the most articles, followed by the USA. Cooperation between countries has progressed over the past decade. Shanghai Jiao Tong University and Oncotargets and Therapy were the institution and journal that published the most articles respectively. The most frequently cited article in this field, titled “Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver,” was published in Nature Cell Biology. Keywords were divided into three: Mechanism research, treatment application research, and diagnosis and prognosis research of which the latter was the newest cluster. “Microenvironment,” “PD-L1” and “M2 macrophage” were representative new keywords while “tumor suppressor” was the keyword cited most frequently. Conclusion: The publication trend shows that cooperation between different countries and institutions contributes to the development of this field. Researchers should continue to extend collaborations for further advances. The rising relative research interest indicated that this is a hot topic with great research potential. Macrophages polarization and PD-L1 application in tumor immunotherapy are worthy of further research. Hotspots will likely transfer from mechanistic research to clinical research, particularly for methods to increase the survival rate and improve the prognosis of cancer patients.
Structural, static, and dynamic functional MRI predictors for conversion from mild cognitive impairment to Alzheimer's disease: Inter‐cohort validation of Shanghai Memory Study and ADNI

Mild cognitive impairment (MCI) is a critical prodromal stage of Alzheimer's disease (AD), and the mechanism underlying the conversion is not fully explored. Construction and inter‐cohort validation of imaging biomarkers for predicting MCI conversion is of great challenge at present, due to lack of longitudinal cohorts and poor reproducibility of various study‐specific imaging indices. We proposed a novel framework for inter‐cohort MCI conversion prediction, involving comparison of structural, static, and dynamic functional brain features from structural magnetic resonance imaging (sMRI) and resting‐state functional MRI (fMRI) between MCI converters (MCI_C) and non‐converters (MCI_NC), and support vector machine for construction of prediction models. A total of 218 MCI patients with 3‐year follow‐up outcome were selected from two independent cohorts: Shanghai Memory Study cohort for internal cross‐validation, and Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort for external validation. In comparison with MCI_NC, MCI_C were mainly characterized by atrophy, regional hyperactivity and inter‐network hypo‐connectivity, and dynamic alterations characterized by regional and connectional instability, involving medial temporal lobe (MTL), posterior parietal cortex (PPC), and occipital cortex. All imaging‐based prediction models achieved an area under the curve (AUC) > 0.7 in both cohorts, with the multi‐modality MRI models as the best with excellent performances of AUC > 0.85. Notably, the combination of static and dynamic fMRI resulted in overall better performance as relative to static or dynamic fMRI solely, supporting the contribution of dynamic features. This inter‐cohort validation study provides a new insight into the mechanisms of MCI conversion involving brain dynamics, and paves a way for clinical use of structural and functional MRI biomarkers in future.
New Types of Magnetic Nanoparticles for Stimuli‐Responsive Theranostic Nanoplatforms

Abstract Magnetic nanomaterials have played a crucial role in promoting the application of nanotechnology in the biomedical field. Although conventional magnetic nanomaterials such as iron oxide nanoparticles (NPs) are used as biosensors, drug delivery vehicles, diagnostic and treatment agents for several diseases, the persistent pursuit of high‐performance technologies has prompted researchers to continuously develop new types of magnetic nanomaterials such as iron carbide NPs. Considering their potential application in biomedicine, magnetic NPs responsive to exogenous or endogenous stimuli are developed, thereby enhancing their applicability in more complex versatile scenarios. In this review, the synthesis and surface modification of magnetic NPs are focused, particularly iron carbide NPs. Subsequently, exogenous and endogenous stimuli‐responsive magnetic NP‐based theranostic platforms are introduced, particularly focusing on nanozyme‐based technologies and magnetic NP‐mediated immunotherapy, which are emerging stimuli‐responsive treatments. Finally, the challenges and perspectives of magnetic NPs to accelerate future research in this field are discussed.
Analysis about technology requirements for Development of Disaster Detecting Satellite Sensor

Since concentration of greenhouse gas increases continuously from human's fossil fuel use, urbanization, and cultivation, it is trend that climate change is appearing. In Addition, in 20th century, occurrence of disaster is accidental and huge, and damage level also increases gradually. Therefore, in order to preserve the territory and to protect people's life and property against new type disasters, disaster detection satellite (payloads) development is required urgently. In this paper, we conduct a research and development for the prompt preemptive action when occurred a disaster, in particularly, about the disaster observation optimized at Korea's geographical features for the irregular future disasters. For the payload design which is specialized detect disasters, we create a tech tree of satellite imagery applications based 10 disaster types, and analyze the satellite sensor technologies referred to Landsat-8, Worldview-3 and ALOS-2.
Evolucion de la temperatura maxima estival en Espana. Parte I: Tendencias y patrones espaciales

Aim of this contribution is to describe the time evolution of daily maximum temperature over mainland Spain, as part from the analysis of bi-monthly correlative series for the months from June to September, and identify the spatial patterns characterising their behaviour by means of a Principal Component Analysis. Results indicate similar interannual evolution to the detected for the whole year(? ), showing the beginning of the summer (June-July) the highest increase over the three identified spatial patterns of daily maximum temperature. These spatial patterns identify during summer three sectors: central Spain, southwest Spain and the Mediterranean littoral.
Selection despite low genetic diversity and high gene flow in a rapid island invasion of the bumblebee, Bombus terrestris

Invasive species are predicted to adjust their morphological, physiological and life‐history traits to adapt to their non‐native environments. Although a loss of genetic variation during invasion may restrict local adaptation, introduced species often thrive in novel environments. Despite being founded by just a few individuals, Bombus terrestris (Hymenoptera: Apidae) has in less than 30 years successfully spread across the island of Tasmania (Australia), becoming abundant and competitive with native pollinators. We use RADseq to investigate what neutral and adaptive genetic processes associated with environmental and morphological variation allow B. terrestris to thrive as an invasive species in Tasmania. Given the widespread abundance of B. terrestris, we expected little genetic structure across Tasmania and weak signatures of environmental and morphological selection. We found high gene flow with low genetic diversity, although with significant isolation‐by‐distance and spatial variation in effective migration rates. Restricted migration was evident across the mid‐central region of Tasmania, corresponding to higher elevations, pastural land, low wind speeds and low precipitation seasonality. Tajima's D indicated a recent population expansion extending from the south to the north of the island. Selection signatures were found for loci in relation to precipitation, wind speed and wing loading. Candidate loci were annotated to genes with functions related to cuticle water retention and insect flight muscle stability. Understanding how a genetically impoverished invasive bumblebee has rapidly adapted to a novel island environment provides further understanding about the evolutionary processes that determine successful insect invasions, and the potential for invasive hymenopteran pollinators to spread globally.
SegVol: Universal and Interactive Volumetric Medical Image Segmentation

Precise image segmentation provides clinical study with instructive information. Despite the remarkable progress achieved in medical image segmentation, there is still an absence of 3D foundation segmentation model that can segment a wide range of anatomical categories with easy user interaction. In this paper, we propose a 3D foundation segmentation model, named SegVol, supporting universal and interactive volumetric medical image segmentation. By scaling up training data to 90K unlabeled Computed Tomography (CT) volumes and 6K labeled CT volumes, this foundation model supports the segmentation of over 200 anatomical categories using semantic and spatial prompts. Extensive experiments on 10 internal validation tasks and 18 external validation tasks verify that SegVol outperforms the state of the art by a large margin. Through its capacity to provide precise volumetric segmentation across various anatomical categories, SegVol has the potential to accelerate advancements in medical imaging diagnosis and facilitate treatment optimization. The model and code are publicly available at: https://github.com/BAAI-DCAI/SegVol.