Miracle-dz/UniFAR-FTUs huggingface dataset:
Failure of Head and Neck Malignancies: A PET/MR Imaging in Evaluating Treatment

BACKGROUND AND PURPOSE: PET/MR imaging is a relatively new hybrid technology that holds great promise for the evaluation of head and neck cancer. The aim of this study was to assess the performance of simultaneous PET/MR imaging versus MR imaging in the evaluation of posttreatment head and neck malignancies, as determined by its ability to predict locoregional recurrence or progression after imaging. MATERIALS AND METHODS: The electronic medical records of patients who had posttreatment PET/MR imaging studies were reviewed, and after applying the exclusion criteria, we retrospectively included 46 studies. PET/MR imaging studies were independently reviewed by 2 neuroradiologists, who recorded scores based on the Neck Imaging Reporting and Data System (using CT/PET-CT criteria) for the diagnostic MR imaging sequences alone and the combined PET/MR imaging. Treatment failure was determined with either biopsy pathology or initiation of new treatment. Statistical analyses including univariate association, interobserver agreement, and receiver operating characteristic analysis were performed. RESULTS: There was substantial interreader agreement among PET/MR imaging scores ( k ¼ 0.634; 95% CI, 0.605 – 0.663). PET/MR imaging scores showed a strong association with treatment failure by univariate association analysis, with P , . 001 for the primary site, neck lymph nodes, and combined sites. Receiver operating characteristic curves of PET/MR imaging scores versus treatment failure indicated statistically signi ﬁ cant diagnostic accuracy (area under curve range, 0.864 – 0.987; P , .001). CONCLUSIONS: Simultaneous PET/MR imaging has excellent discriminatory performance for treatment outcomes of head and neck malignancy when the Neck Imaging Reporting and Data System is applied. PET/MR imaging could play an important role in surveillance imaging for head and neck cancer.
Assessment Using MR Neurography Receptor 4 Activation on Neurotmesis: Enhanced Repair Effect of Toll-Like

BACKGROUND AND PURPOSE: Alternative use of molecular approaches is promising for improving nerve regeneration in surgical repair ofneurotmesis.ThepurposeofthisstudywastodeterminetheroleofMRimaginginassessmentoftheenhancednerveregenerationwith toll-like receptor 4 signaling activation in surgical repair of neurotmesis. MATERIALS AND METHODS: Forty-eight healthy rats in which the sciatic nerve was surgically transected followed by immediate surgical coaptation received intraperitoneal injection of toll-like receptor 4 agonist lipopolysaccharide ( n (cid:2) 24, study group) or phosphate buffered saline ( n (cid:2) 24, control group) until postoperative day 7. Sequential T2 measurements and gadoﬂuorine M-enhanced MR imaging and sciatic functional index were obtained over an 8-week follow-up period, with histologic assessments performed at regular intervals. T2relaxationtimesandgadoﬂuorineenhancementofthedistalnervestumpsweremeasuredandcomparedbetweennervestreatedwith lipopolysaccharide and those treated with phosphate buffered saline. RESULTS: Nerves treated with lipopolysaccharide injection achieved better functional recovery and showed more prominent gadoﬂuo-rine enhancement and prolonged T2 values during the degenerative phase compared with nerves treated with phosphate buffered saline. T2 values in nerves treated with lipopolysaccharide showed a more rapid return to baseline level than did gadoﬂuorine enhancement. Histology exhibited more macrophage recruitment, faster myelin debris clearance, and more pronounced nerve regeneration in nerves treated with toll-like receptor 4 activation. CONCLUSIONS: The enhanced nerve repair with toll-like receptor 4 activation in surgical repair of neurotmesis can be monitored by using gadoﬂuorine M-enhanced MR imaging and T2 relaxation time measurements. T2 relaxation time seems more sensitive than gado-ﬂuorine M-enhanced MR imaging for detecting such improved nerve regeneration.
Prevalence and predictors of sleep apnea in patients with stable coronary artery disease: a cross-sectional study

Background: Sleep apnea (SA) is increasingly recognized as being important in the prognosis of patients with coronary artery disease (CAD); however, symptoms of SA are not easily identified, and as many as 80% of sufferers remain undiagnosed. Aim: This cross-sectional study investigated the prevalence and predictors of SA that may help to increase the awareness and diagnosis of SA in stable CAD patients. Materials and methods: Polysomnography was performed in 772 medically stable CAD patients with untreated SA recruited from the Clinic of Cardiovascular Rehabilitation. Patients were predominantly male (76%), median age was 58 years (32–81). All subjects completed the Epworth sleepiness scale (ESS). The frequency of all apneas and hypopneas associated with 3% oxygen desaturation is referred to as the apnea–hypopnea index (AHI). Mild-to-severe SA was defined as AHI $ 5/h, moderate-to-severe SA as AHI $ 15/h. Results: AHI was within a range of values that was considered normal or only mildly elevated. The median AHI was 3.4 (interquartile range [IQR 1–9]), and 39% of patients had unrecognized mild-to-severe SA (moderate-to-severe in 14%), which was not higher than other known risk indicators for CAD such as hypertension and obesity (83% and 47%, respectively). These patients did not show sleepiness and the risk-related cut-off score for excessive daily sleepiness was lower than the official for ESS. Conclusion: Hypertension, age, male gender, obesity, ESS $ 6, and left ventricular ejection fraction # 45% were the best predictors of mild-to-severe SA. While, male gender, age 50–70 years and, mainly, the presence of obesity but not hypertension were clinical predictors for moderate-to-severe SA. In addition, association between mild-to-severe SA and obesity was not evident in women. SA is prevalent comorbidity in the stable CAD patients, especially in its asymptomatic mild form. We suggest that SA should be considered in the secondary prevention protocols for CAD.
Integrated Behavioral Health Adaptations During the COVID-19 Pandemic

Introduction: COVID-19 pandemic lockdowns threatened standard components of integrated behavioral health (IBH) such as in-person communication across care teams, screening, and assessment. Restrictions also exacerbated pre-existing challenges to behavioral health (BH) access. Methods: Semistructured interviews were completed with clinicians from family medicine residency programs on the impact of the pandemic on IBH care delivery along with adaptations employed by care teams to ameliorate disruption. Results: Participants (n = 41) from 14 family medicine residency programs described the rapid shift to virtual care, creating challenges for IBH delivery and increased demand for BH services. With patients and care team members at home, virtual warm handoffs and increased attention to communication were necessary. Screening and measurement were more difficult, and referrals to appropriate services were challenging due to higher demand. Tele-BH facilitated continued access to BH services but was associated with logistic challenges. Participants described adaptations to stay connected with patients and care teams and discussed the need to increase capacity for both in-person and virtual care. Discussion: Most practices modified their workflows to use tele-BH as COVID-19 cases increased. Participants shared key learnings for successful implementation of tele-BH that could be applied in future health care crises. Conclusion: Practices adapted readily to challenges posed by pandemic restrictions and their ability to sustain key elements of IBH during the COVID-19 pandemic demonstrates innovation in maintaining access when in-person care is not possible, informing strategies applicable to other scenarios.
: Comparing Two Utility Measures to Social Class

Based upon the Behavioral Perspective Model (BPM), previous study showed that consumers tend to maximize utility as a function of the level of utilitarian (functional) and informational (social) reinforcement offered by brands. A model of consumer brand choice was developed, which applied a Cobb-Douglas utility function to the parameters that constitute the BPM, using consumer panel data. The present paper tested a variation of the previous model, which allows for measures of consumer utility at the level of aggregate household, in addition to utility per consumed product unit (e.g., gram), and examined the relations of obtained utility with consumers' social class and age. Results indicate that the model fitted the data well, generating consistent parameters, and that utility per product unit, but not total household utility, was positive correlated to social class. These findings suggest that, in the case of supermarket food items, higher-income households obtain higher levels of utility than lower-income households by purchasing brands that offer more utilitarian and informational reinforcement per product unit rather them buying larger quantities of brands offering lower reinforcement levels.
Outliers in Evidential C-Means: An Empirical Exploration using Survey Data on Organizational Social Capital

Evidential C-Means (ECM) is a technique for cluster analysis, which has a methodology based on the Dempster-Shafer theory of evidence (DST). To date this technique has been theoretically discussed but has had limited application. Based on DST, ECM facilitates the association of objects to sets of clusters, rather than simply a single cluster. One feature of ECM is the facility for classifying cases to no cluster, the level of which is effected by the parameters in ECM (in particular , which controls for the datapoints considered outliers). In this study, the substantive effects of varying  are explored by investigating the relationship between organziational social capital and employee engagement. Drawing on a large-N survey of senior public sector executives, the clustering of different dimensions of organizational social capital is undertaken, and the relationship between those clusters and employee engagement analysed at varying levels of . The implications of the findings are discussed.
The value of ovarian hyperstimulation syndrome in predicting pregnancy outcome in women with polycystic ovarian syndrome and candidate for in vitro fertilization: A case-control study

Abstract Background: Ovarian hyperstimulation syndrome (OHSS) as a known complication in women with polycystic ovarian syndrome (PCOS) may occur following inducible fertility treatments such as in vitro fertilization (IVF) and can affect the sequels of these treatments. Objective: This study aimed to assess the effects of OHSS on pregnancy outcomes through IVF in women with PCOS. Also, we assessed the value of baseline sexual hormones to predict the pregnancy's success. Materials and Methods: This case-control study was conducted on 180 consecutive women suffering from PCOS who were candidates for IVF at Fatemieh hospital in Hamadan, Iran, from May-July 2022. The women were assigned to the case group (with OHSS, n = 129) and the control group (without OHSS, n = 51). Measuring the sexual hormones was performed using the enzyme-linked immunosorbent technique. Results: In the multivariable logistic regression model, OHSS could not predict the likelihood of clinical or chemical pregnancy following IVF. None of the baseline sexual hormones could predict the successful chemical or clinical pregnancy in PCOS women following IVF. Conclusion: OHSS may not influence IVF-related outcomes in PCOS women. The values of sexual hormones may not also determine the pointed outcome.
Study to determine the prevalence of Helicobacter pylori infection among the Sirte population (Libya) using an Antibody Rapid Test Cassette method.

Helicobacter pylori (H. pylori) is a major pathogen in the context of gastroduodenal ulceration, gastric carcinoma, and other types of gastric and extra gastric disease. H. pylori infection can be diagnosed by different methods including invasive techniques such as endoscopy and biopsy, and non-invasive methods such as urea breath and serology tests for the detection of antibody and antigens. This required expensive laboratory equipment compared with the Antibody Rapid Test Cassette method for detection and diagnosis of H. pylori. Objective: This study aimed to determine the prevalence of H. pylori infection among the Sirte population (Libya) using an Antibody Rapid Test Cassette method. The Antibody Rapid Test Cassette method is a rapid, cheap, and simple test that utilizes a combination of H. pylori antigen and anti-human IgG to qualitatively and selectively detect H. pylori antibodies in serum. Methods: A total of 60 patients (30 males and 30 females) having H. pylori symptoms, were included in the study, Blood samples were collected from these 60 patients from different clinical laboratories in Sirte. All the samples were tested for H. pylori antibody using an (Antibody Rapid Test Cassette method). Results: Results showed that a positive antibody was detected in 50 samples of the 60 samples (the infection rate was 83%). There was a high level of antibody against H. pylori in 35/50 of the positive samples. 20 of the patients with higher levels were Male and 15 were female. 15/50 were low or medium positive reaction, P≤0.1099. Whilst 10/60 (16.66%) of the samples were negative, 3 of these 3 were from male patients, and 7 were from female patients. Conclusion: Serologic tests are widely available, noninvasive, inexpensive, and appropriate for screening in large epidemiologic studies. The occurrence of H. pylori infection reported in our study was high and therefore calls for health education about behavioral changes and adequate sanitation; Population screening and diagnosis using multiple tests are required to reduce H. pyloric infections.
THE IMPACT OF ENGAGEMENT ON JOB COMPLETION’S LEVEL OF MEDICAL STAFF: A CASE AT THAI THUY GENERAL HOSPITAL, THAI BINH

Introduction: Healthcare workers play an important role in the delivery of healthcare around the world. The purpose of this analysis was to explore the impact of healthcare workers’ organizational commitment, controlling for demographic variables, on job satisfaction, particularly in the context of the mid-career health sector going through a stressful period in the fight against the COVID-19 pandemic. Methods: This study used a hospital assessment toolkit issued by the Vietnamese Ministry of Health, surveying 156 medical staffs directly providing health care services at Thai Thuy General Hospital, Thai Binh province. Results: The analysis results by the PLS-SEM structural equation model show that, when the cohesion of medical staff is improved, it will lead to a higher level of job completion. Besides, the medical staff must concurrently take on other jobs, which will negatively affect the level of job completion. Conclusion: This implies that the level of the job performance of healthcare workers can depend to a large extent on the organizational commitment and the medical staff’s single duty.
Prevalencia y factores asociados al ingreso a la unidad de cuidados intensivos en niños hospitalizados por neumonía adquirida en la comunidad

Objetivo. Determinar la prevalencia y los factores asociados al ingreso a la unidad de cuidados intensivos en niños y adolescentes con neumonía adquirida en la comunidad. Materiales y métodos. Estudio observacional transversal analítico en el Instituto Nacional de Salud del Niño San Borja en el 2019, la muestra estuvo conformada por niños de mayores de un mes y menores de 18 años que ingresaron a emergencia con diagnóstico de neumonía adquirida en la comunidad. Se utilizó la regresión de Poisson para evaluar asociación. Resultados. Se evaluaron 166 pacientes con diagnóstico de neumonía, 94 (56,6%) fueron varones y la mediana de la edad fue 24 meses (RIC: 11‒48). La mayoría de los pacientes presentó un puntaje PIRO modificado leve de 136 (81,9%), 31 (18,7%) pacientes tuvieron neumonía complicada y 24 (14,5%) ingresaron a cuidados intensivos. A mayor edad se halló menor prevalencia de ingreso a UCI (RP=0,99, IC95%: 0,98‒0,99); la gravedad evaluada con el score PIRO modificado (RP=3,40, IC95%: 1,46‒7,93) y la presencia de neumonía complicada (RP: 5,88, IC95%: 2,46‒14,06) estuvieron asociados al ingreso a cuidados intensivos. Conclusiones. En niños con neumonía adquirida en la comunidad la prevalencia de ingreso a cuidados intensivos fue de 14,5%. Los pacientes con neumonía de menor edad, con mayor gravedad evaluada con el puntaje PIRO modificado y con neumonía complicada tienen mayor prevalencia de ingreso a cuidados intensivos.
On the periphery of the Magdalenian World: An open-air site in Klementowice

The archaeological site in Klementowice is the north-easternmost settlement point of the Magdalenian technocomplex in Europe. The paper presents the results of geoarchaeological investigations focused on recognition, identification, and interpretation of environmental determinants of the site location. The specific and favourable geographical position of the site in the Late Glacial is distinctly visible at the macroregional scale (at the border of contrasting megaregions e highlands/lowlands with different environmental conditions) as well as the microregional scale (specific local conditions). The site has been known since the early 1980s. In 2007, excavations were resumed and a new, previously unknown concentration of artefacts was discovered. The flint inventory from the site exhibits close analogies with the areas of Moravia and Central Germany. The new data from several thousands of flint artefacts and first discovery of faunal remains (Equus ferus) indicate that there was multi-seasonal hunting camp in this area. 2012 Elsevier Ltd and INQUA.
Spatial Thinking Assists Geographic Thinking: Evidence from a Study Exploring the Effects of Geospatial Technology

Abstract This article provides a description and discussion of an exploratory research study that examined the effects of using geospatial technology (GST) on high school students’ spatial skills and spatial-relations content knowledge. It presents results that support the use of GST to teach spatially dependent content. It also provides indication of an important link between spatial thinking and geographic thinking. The article concludes with a discussion of how these results inform instructional strategies for the teaching of geography.
ABA-CsABI5-CsCalS11 module upregulates Callose deposition of citrus infected with Candidatus Liberibacter asiaticus

Abstract Huanglongbing (HLB) primarily caused by Candidatus Liberibacter asiaticus (CLas) has been threatening citrus production globally. Under HLB conditions, an excessive accumulation of the polysaccharide callose in citrus phloem occurs, leading to phloem blockage and starch accumulation in leaves. The callose production is controlled by callose synthases (CalS), which have multiple members within plants. However, the knowledge of callose production in the citrus upon infection with CLas is limited. In this study, we firstly identified 11 CalSs in the Citrus sinensis genome through bioinformatics and found the expression pattern of CsCalS11 exhibited a positive correlation with callose deposition in CLas-infected leaves (correlation coefficient of 0.77, P ≤ 0.05). Knockdown of CsCalS11 resulted in a reduction of callose deposition and starch accumulation in CLas-infected citrus. Interestingly, we observed significantly higher concentrations of abscisic acid (ABA) in HLB-infected citrus leaves compared to uninfected ones. Furthermore, the expressions of CsABI5, CsPYR, and CsSnRK2 in the ABA pathway substantially increased in citrus leaves upon CLas infection. Additionally, the expression of CsCalS11 was significantly upregulated in citrus leaves following the application of exogenous ABA. We confirmed that CsABI5, a pivotal component of the ABA signaling pathway, regulates CsCalS11 expression by binding to its promoter using yeast one-hybrid assay, dual luciferase assay, and transient expression in citrus leaves. In conclusion, our findings strongly suggest that the CsABI5-CsCalS11 module plays a crucial role in regulating callose deposition through the ABA signaling pathway during CLas infection. The results also revealed new function of the ABA signaling pathway in plants under biotic stress.
Tear Samples for Protein Extraction: Comparative Analysis of Schirmer's Test Strip and Microcapillary Tube Methods

Introduction: Tear sampling is an attractive option for collecting biological samples in ophthalmology clinics, as it offers a non-invasive alternative to other invasive techniques. However, there are many tear sampling methods still in consideration. This study explores the suitability of Schirmer’s test strip and microcapillary tube as reliable and satisfactory methods for tear sampling. Methods: Tear samples were collected from eight healthy volunteers using the standard Schirmer's test strip method with or without anesthesia and microcapillary tubes. The total tear protein concentrations were analyzed via spectrophotometry and bicinchoninic acid (BCA) protein assay. The protein profile was determined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). The optimal wetting length of Schirmer's strip and suitable buffer solutions were compared. Discomfort levels reported by participants and the ease of execution for ophthalmologists were also evaluated. Results: Tear samples exhibited typical protein profiles as shown by SDS-PAGE. The mean total protein obtained from an optimum wetting length of 20 mm using Schirmer's strip without anesthesia in phosphate-buffered saline (PBS) yielded substantial quantities of protein as measured by nanophotometer (220.20 ± 67.43 µg) and the BCA protein assay (210.34 ± 59.46 µg). This method collected a significantly higher quantity of protein compared to the microcapillary tube method (p=0.004) which was much more difficult to standardize. The clinician found it harder to utilize microcapillary tubes, while participants experienced higher insecurity and less discomfort with the microcapillary tube method. PBS used during the tear protein extraction process eluted higher tear protein concentration than ammonium bicarbonate, although the difference was not statistically significant. Using anaesthesia did not ease the sampling procedure substantially and protein quantity was maintained. Conclusion: Good quality and quantity of protein from tear samples were extracted with the optimized procedure. Schirmer's strip test in the absence of local anesthesia provided a standard, convenient, and non-invasive method for tear collection.