Miracle-dz/UniFAR-FTUs huggingface dataset:
Time-lapse-Embryomonitoring und Oozyten- vitrifikation: Neue Verfahren in der Reproduktions- medizin aus ethischer Sicht *

Zurzeit zeigt sich der stetige technische Fortschritt der Reproduktionsmedizin an zwei neuen Verfahren. Es geht um die Moglichkeit, auserkorperlich erzeugte Embryonen in neuartigen Inkubatorsystemen zu beobachten (Time-lapse-Monitoring), und um die Kryokonservierung von Eizellen (Oozytenvitrifikation). Das Einfrieren von Eizellen kann in Frage kommen, wenn eine Frau einen Kinderwunsch aus personlichen oder sozialen Grunden auf einen spateren Zeitpunkt verschieben mochte („social egg freezing“) oder wenn sie sich aus Krankheitsgrunden einer keimzellschadigenden Behandlung aussetzen lassen muss (medizinisch indizierte Vitrifikation). Der Artikel beleuchtet diese unterschiedlichen Handlungsoptionen unter ethischen Aspekten. Er wagt jeweils ihre normative Vertraglichkeit, ihre Humanvertraglichkeit und ihre Sozialvertraglichkeit ab und halt sie – bei manchen Differenzen, die im Einzelnen bestehen – insgesamt fur ethisch vertretbar. Fur konkrete Entscheidungen kommt es auf den Einzelfall und auf die Einzelumstande an. Schlusselworter: Ethik, Embryo, Embryoskopie, Oozytenvitrifizierung, social freezing, keimzellschadigende Therapie, reproduktive Autonomie, Praventivmedizin Time Lapse Monitoring and Oocyte Vitrification. The Ethical View of New Techniques in Reproductive Medicine. Currently, two new methods bear witness to the continuing scientific progress in the field of reproduction medicine. There is now the possibility to observe in vitro-produced embryos in new types of incubator systems (time lapse monitoring) and to store oocytes by means of cryoconservation (oocyte vitrification). The cryogenic freezing of oocytes can be an option when a woman wishes to postpone her pregnancy due to personal or social reasons (social egg freezing) or when she has to undergo germ cell-damaging treatment (medically indicated vitrification). The article analyses the various courses of action from an ethical perspective. It weighs up the normative, human and social compatibility of the various options available. In principle, the article considers these options as ethically justifiable – albeit with differences that exist in the detail. In order to make concrete decisions both the individual case and the individual circumstances surrounding it need to be taken into consideration. J Reproduktionsmed Endokrinol 2013; 10 (3): 163–7.
Efecto de la aplicación de cuatro ácidos orgánicos y de un detergente neutro sobre la carga microbiana total y Escherichia coli en broza del café costarricense

Dada la importancia de la actividad cafetalera en Costa Rica, existe un gran numero de beneficios de cafe que generan un considerable volumen de residuos contaminantes, como lo son las aguas de desecho, las mieles y la pulpa o broza. En la mayoria de los casos, dichos subproductos son vertidos directamente a los rios y las tierras superficiales, lo que provoca una gran contaminacion, especialmente en las epocas de cosecha. En el beneficio de cafe, la broza se trata como un desecho, por lo que contamina fuertemente, ya que el interes principal de esta industria no es la broza, sino el grano. Sin embargo, en numerosos estudios se ha demostrado que la broza del cafe es una fuente de polifenoles que podrian ser aprovechados, de alguna manera en la industria; por lo tanto, la presente investigacion evalua la calidad microbiologica de la broza del cafe proveniente de un beneficio del Valle Central y el efecto de varios acidos organicos y de un detergente neutro sobre su carga microbiana, para evaluar la posibilidad de que este subproducto tenga un uso alternativo como materia prima para futuros productos alimenticios con valores nutraceuticos.El estudio dio como resultado que solamente dos de los acidos utilizados disminuyen significativamente la carga microbiana inicial de la broza, pero que, aun asi, dicha disminucion no cumplio con los niveles establecidos para un producto alimenticio por el Reglamento Tecnico Centroamericano (2009), (limite maximo 1000 UFC para la carga microbiana total como recuento total aerobio y < 3 NMP/g para Escherichia coli). Por lo anterior, se deberan realizar estudios adicionales, utilizando otros tipos de desinfectantes y aumentado la concentracion de los ya estudiados, sobre todo cambiando las practicas del manejo del grano que se da en estos lugares, a fin de obtener una broza menos contaminada.
Portal Vein Pulsatility as a Dynamic Marker of Venous Congestion Following Cardiac Surgery: An Interventional Study Using Positive End-Expiratory Pressure

We aimed to assess variations in the portal vein pulsatility index (PI) during mechanical ventilation following cardiac surgery. Method. After ethical approval, we conducted a prospective monocentric study at Amiens University Hospital. Patients under mechanical ventilation following cardiac surgery were enrolled. Doppler evaluation of the portal vein (PV) was performed by transthoracic echography. The maximum velocity (VMAX) and minimum velocity (VMIN) of the PV were measured in pulsed Doppler mode. The PI was calculated using the following formula (VMAX − VMIN)/(VMax). A positive end-expiratory pressure (PEEP) incremental trial was performed from 0 to 15 cmH2O, with increments of 5 cmH2O. The PI (%) was assessed at baseline and PEEP 5, 10, and 15 cmH2O. Echocardiographic and hemodynamic parameters were recorded. Results. In total, 144 patients were screened from February 2018 to March 2019 and 29 were enrolled. Central venous pressure significantly increased for each PEEP increment. Stroke volumes were significantly lower after PEEP incrementation, with 52 mL (50–55) at PEEP 0 cmH2O and 30 mL (25–45) at PEEP 15 cmH2O, (p < 0.0001). The PI significantly increased with PEEP incrementation, from 9% (5–15) at PEEP 0 cmH2O to 15% (5–22) at PEEP 5 cmH2O, 34% (23–44) at PEEP 10 cmH2O, and 45% (25–49) at PEEP 15 cmH2O (p < 0.001). Conclusion. In the present study, PI appears to be a dynamic marker of the interaction between mechanical ventilation and right heart pressure after cardiac surgery. The PI could be a useful noninvasive tool to monitor venous congestion associated with mechanical ventilation.
Enriching and Clustering Short Text Using KNN

Semantic Hashing technique wraps the meaning of short texts into compressed binary codes. So, to find out that whether two short texts are alike or not in their meaning, their binary codes need to be matched. A deep neural network is used for encoding. Bag-of-words representation of texts is used to train the neural network. Unfortunately, the fundamental semantics are not sufficiently captured by the above mentioned form of representation for short texts such as titles, tweets, or queries. We propose adding additional semantic signals to better group short texts using their meaning. More specifically, we procure the co-occurring terms and concepts of every term in the short text via a knowledge database to further enhance the short text. Additionally, we use a k-Nearest Neighbor based approach id for hashing. Multiple experiments provide evidence that by increasing the number of semantic signals, our neural network is better capable to capture the meaning of short texts, which enables various uses like retrieving information, classifying data, and processing of short texts. keywords: Short Text, k-Nearest Neighbor, Semantic Enrichment, Hashing.
The Transmembrane Receptor TIRC7 Identifies a Distinct Subset of Immune Cells with Prognostic Implications in Cholangiocarcinoma

Simple Summary Cholangiocarcinoma (CCA) is an epithelial malignancy with a dismal prognosis due to rapid tumoral spread and poor therapeutic options. Innovative therapies, such as immune-modulating drugs, are urgently needed. Here, we assessed the quantity and clinical implications of immune cells expressing the T cell immune response cDNA 7 receptor (TIRC7) in a cohort of 135 CCA patients. We found that TIRC7+ immune cells are present both in the tumor epithelia and in the stroma in the majority of patients with particularly high intraepithelial levels in intrahepatic CCA. Distinct histomorphological tumor subtypes were exclusively associated with a TIRC7+ phenotype. By correlation analysis, we uncovered that a high level of intraepithelial TIRC7+ immune cells was associated with a favorable prognosis in intrahepatic CCA. Our results reveal a distinct subset of immune cells marked by TIRC7 to be present and prognostically relevant in CCA. Abstract Cholangiocarcinoma (CCA) is a heterogeneous malignancy with a dismal prognosis. Therapeutic options are largely limited to surgery and conventional chemotherapy offers limited benefit. As immunotherapy has proven highly effective in various cancer types, we have undertaken a quantitative immunohistopathological assessment of immune cells expressing the immunoinhibitory T cell immune response cDNA 7 receptor (TIRC7), an emerging immunoinhibitory receptor, in a cohort of 135 CCA patients. TIRC7+ immune cells were present in both the tumor epithelia and stroma in the majority of CCA cases with the highest levels found in intrahepatic CCA. While intraepithelial density of TIRC7+ immune cells was decreased compared to matched non-neoplastic bile ducts, stromal quantity was higher in the tumor samples. Tumors exhibiting signet ring cell or adenosquamous morphology were exclusively associated with an intraepithelial TIRC7+ phenotype. Survival analysis showed intraepithelial TIRC7+ immune cell density to be a highly significant favorable prognosticator in intrahepatic but not proximal or distal CCA. Furthermore, intraepithelial TIRC7+ immune cell density correlated with the number of intraepithelial CD8+ immune cells and with the total number of CD4+ immune cells. Our results suggest the presence and prognostic relevance of TIRC7+ immune cells in CCA and warrant further functional studies on its pharmacological modulation.
Developing pattern languages: new ways of communicating naturalistic insights for system development and evaluation

Motivation - The Naturalistic Decision Making (NDM) community benefits from having its insights used in software development projects. Research approach - We are investigating the pattern form as a way to incorporate findings from naturalistic research into software development. The sociotechnical level of description - how technology impacts groups, teams, and organizations - is the focus of our work. Findings/Design - Pattern form offers the advantage of focusing interpretation and connecting to a solution outline over more traditional ways of making findings available. These advantages also make the pattern form good for use in the evaluation of systems where the need for solutions is immediate. Research limitations/Implications - The pattern form is not a panacea and will not replace NDM participation in development projects. Originality/Value - Patterns have not been used for evaluation at the socio-technical level. Take away message - Patterns may be useful for communicating NDM insights in development projects, particularly those at the socio-technical level.
Radioactive 125I Seed Implantation for Recurrent Cervical Carcinoma After Surgery and Radiotherapy: A Case Report

Background: The prognosis of cervical cancer is remarkable, but there are still instances of pelvic and/or extrapelvic recurrence after radical hysterectomy with platinum-based chemoradiotherapy. Sixty percent of the patients with radiotherapy (RT) failure have pelvic recurrence, and 80% of them relapse within two years after treatment. Recurrent cervical cancer seriously affects the prognosis and survival rate of patients. Due to the dose limitation for normal tissue, it is difficult to deliver a sufficient number of doses to recurrent lesions through reirradiation. With the rapid development of brachytherapy technologies such as three-dimensional afterloading brachytherapy, interstitial brachytherapy and radioactive 125I seed implantation, the overall survival (OS) of patients with recurrent cervical cancer has been improving. In the present study, a case in which the patient was successfully treated with radioactive 125I seed implantation is reported.Case presentation: The patient, a 47-year-old woman, was initially diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IB cervical cancer and received preoperative radiotherapy, radical hysterectomy, pelvic lymph node dissection and postoperative radiotherapy. After 95 months of follow-up, retroperitoneal lymph node metastasis and edema of the left lower limb . The size of the retroperitoneal lesion was 2.3 × 2.0 cm, and the size of the left supraclavicle lesion was 2.0 × 1.5 cm. Radioactive 125I seed implantation was performed for retroperitoneal lymph node metastasis and left supraclavicular metastasis. Paclitaxel and cisplatin chemotherapy were given after the operation. Three months after implantation, the size of the retroperitoneal focus was 1.5 × 1.1 cm, and the size of the left supraclavicular lesion was 1.0 × 0.6 cm. Thirteen months after implantation, according to the RECIST standard, the therapeutic effect reached CR. At the time of submission, the patient's progression-free survival was 6 years and 4 months.Conclusions: CT-guided 125I seed implantation is a safe, effective, and minimally invasive method for treating patients with recurrent cervical cancer after radiotherapy. The response of this patient indicates that 125I seed implantation can be used as a complementary treatment for recurrent cervical cancer after chemoradiotherapy and may also prove to be reliable for comprehensive treatment of cervical cancer.
Regarding all the Food Allergies

When I, sometime later than first published, read the article in the Telegraph newspaper describing the work of Professor Gideon Lack. His observations whilst treating patients, especially very young ones, with emollients to alleviate their skin disorders. He was extremely thorough and took careful histories to search for the causes of their afflictions, i.e., rashes and broken skin. The articles is here, https://www.telegraph. co.uk/news/worldnews/ northamerica/usa/1424292/Peanut-allergy-is-linked-to-creams-for-skin-rashes.html and also available at, https://www.sciencenews. org/blog/food-thought/unexpected-sourcespeanut-allergy. What Prof Lack found very surprisingly was confirmation of some peoples view that peanut-allergy does in fact occur without prior consumption of peanuts or derivatives thereof [1]. Being an organic chemist of considerable experience, I realized from his results that the trigger of peanut allergy in these patients had to reside in the emollients he was using. I also knew of the industrial processing used to produce these emollients from fats, i.e., triglycerides, mostly in the early days from peanut oil, hence the first cases were allergy to peanuts.
Alleviation of side force on tangent-ogive forebodies using passive porosity

An experimental investigation to determine the effectiveness of passive porosity for alleviating side forces on forebodies was conducted in the NASA Langley Research Center 7-ft by 10-ft high-speed wind tunnel. Force, moment, and surface pressure data were obtained on solid and porous (22% porosity, 0.020-in. hole diam) tangent-ogive forebodies of fineness ratios 2.5 and 5.0. The solid forebodies were tested with transition grit to simulate fully turbulent conditions, and without transition grit to simulate free transition conditions. The extent of porosity on the forebodies was varied to determine the extent of porosity needed to alleviate side forces. Static longitudinal and lateral-directional stability and surface pressure data were obtained at Mach numbers of 0.2, 0.5, and 0.8, angles of attack from — 5 to 45 deg, and roll angles from — 90 to 180 deg. The solid forebodies exhibited large asymmetric pressure loads at moderate to high angles of attack causing large side forces and yawing moments; the transition grit had minimal effect on the asymmetric characteristics, but had a large effect on the longitudinal characteristics. The porous forebodies exhibited no significant side forces or yawing moments at any angle of attack tested.
Current Optimization for a Multi-Phase Machine under an Open Circuit Phase Fault Condition

In this paper, a practical method based on a symmetrical component transformation is proposed to analyze and optimize the current for a multi-phase machine under open-circuit phase conditions. Two kinds of current optimization are considered: stator copper loss minimization and inverter peak current minimization. Application of the method is described for a five-phase machine. The fault conditions investigated are single, double, and triple open-circuit phase faults. Optimized solutions for four-, six-, and seven-phase machines, with one open-circuit phase, are also presented.
A CMOS Compatible Traction Stress Sensing Element For Use In High Resolution Tactile Imaging

A microstructure capable of resolving the three independent components of a point traction stress has been developed. The sensor exhibits an independent, linear response to each of the three components of an applied traction stress with measurement sensitivities of 130 mV/(V*kPa) in the normal stress mode and 26 mV/(V*kPa) in the two shear stress modes. The sensor was realized using a fabrication process which is fully CMOS compatible to allow for the future integration of local processing and control circuitry. High spatial resolution robotic tactile sensing may be possible with the sensor structure as each element is less than 300 x 300 /spl mu/m in size. A description of the sensor structure and the required signal processing follows, with mechanical characterization data included.
Image Classification With Convolutional Neural Networks In MapReduce

Deep learning (DL) techniques, more specifically Convolutional Neural Networks (CNNs), have become increasingly popular in advancing the field of data science and have had great successes in a wide array of applications including computer vision, speech, natural language processing and etc. However, the training process of CNNs is computationally intensive and high computational cost, especially when the dataset is huge. To overcome these obstacles, this paper takes advantage of distributed frameworks and cloud computing to develop a parallel CNN algorithm. MapReduce is a scalable and fault-tolerant data processing tool that was developed to provide significant improvements in large-scale data-intensive applications in clusters. A MapReduce-based CNN (MCNN) is developed in this work to tackle the task of image classification. In addition, the proposed MCNN adopted the idea of adding dropout layers in the networks to tackle the overfitting problem. Close examination of the implementation of MCNN as well as how the proposed algorithm accelerates learning are discussed and demonstrated through experiments. Results reveal high classification accuracy and significant improvements in speedup, scaleup and sizeup compared to the standard algorithms.
Alternative Wired and 60-GHz Wireless Full Duplex Access Based on a Polarization Orthogonal Dual-Tone Optical Millimeter-Wave Signal

Abstract A novel full duplex fiber wireless link providing alternative wired and 60-GHz wireless access is proposed based on a polarization orthogonal dual-tone optical millimeter-wave signal. In a hybrid optical network unit, the downlink optical signal can be decomposed as a single-sideband optical millimeter-wave signal (baseband optical signal) for wireless (wired) access by a polarization controller and polarization beam splitter. The uplink optical carrier abstracted from the downlink optical signal makes the hybrid optical network unit free from the optical source. The simulation results show that both downlinks and uplinks for either wired or wireless access can maintain quite good performance over 60 km of fiber.
Switchable single/dual band filtering UWB antenna using parasitic element and T‐shaped stub wave cancellers

A new design of microstrip slot antenna with switchable single and dual band filtering functions for ultrawideband (UWB) applications is presented in this letter. To create filtering quality, in the proposed structure radiating patch is modified embedding two T‐shaped stubs into the radiating patch and also using coupling parasitic element on the ground plane. The measured impedance bandwidth for VSWR <2 is spread in frequency range of 3–16.9 GHz with a fractional bandwidth of 139.7% while filtering the interference with C‐band and wireless local area network systems at 3.4–4.28 GHz and 5.21–6.36 GHz, respectively. Introducing PIN diodes switches to the antenna structure has added an additional merit to the antenna performance which is switchable single/dual band filtering operation. The designed antenna has a simple structure with a very small size of 20 × 20 mm2 while presenting consistent almost omnidirectional radiation characteristics at its vast frequency range of operation. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:2946–2950, 2015
Rectangular waveguide to strip-transmission-line directional couplers

Bethe's small slot coupling formulas are presented in a form covering the general case of coupling between dissimilar transmission lines, and these formulas are applied to the special case of coupling between waveguide and strip transmission line. The theoretical coupling of a rectangular slot in the sidewall is calculated, and the coupling and directivity of multiple element arrays are discussed. Measured data on a basic slot are presented and the design procedure for specific couplers is outlined. The test results on a three and four element binomial array coupler in L-band, capable of carrying 7 megawatts peak power, in nonpressurized guide, is presented.
The Modular Multilevel Converter as Universal High-Precision 3AC Voltage Source for Power Hardware-in-the-Loop Systems

Three-phase voltage sources are power electronic systems, which generate specific, highquality voltage waveforms for many different applications. They are used in Power Hardware-in-the-Loop (PHIL) systems for the emulation of electrical machines or grids as well as in test and measurement systems for the characterization of passive components, transformers, magnetic materials, etc. The proposed 3AC voltage source is realized by a Modular Multilevel Converter (MMC), which generates voltage waveforms with small steps due to its series-connected cells. The quality of the voltage is further improved by a small filter to eliminate harmonics in the range of the switching frequency. Measurements are performed on a low voltage MMC prototype to evaluate the precision of the voltage waveforms. A MMC in 1AC-3AC configuration, which is coupled to a medium frequency transformer, is presented to meet the requirement of a galvanically isolated power supply and to overcome the limitations at low frequency operation.
An Improved Federal Kalman Filter Based on Smoother for Wireless Localization

Federal Kalman filter is often used in multi-sensor wireless localization system. In this paper, we estimate the target location in non line of sight (NLOS) propagation. An approach based on federal Kalman filter is proposed, which is called smooth-federal Kalman filter. Federal Kalman filter uses standard Kalman filter in local filter to processes data in a forward recursion. Kalman smoother which processes data in a backward recursion is addressed in ordinary federal Kalman filter. Simulation and comparison results show that the estimation of the proposed approach performs superior to federal Kalman filter in NLOS propagation.
Analog Optical Computing

After a brief overview on basic analog optical operations we present image amplifiers being realized by two- and four-wave mixing in photorefractive BaTiO3. We summarize some optical operations with photorefractive elements and present for the first time an image transmitting optical feedback system with gain by a phase-conjugating mirror.