Miracle-dz/UniFAR-FTUs huggingface dataset:
Committed, Healthy, and Engaged? Linking Servant Leadership and Adaptive Performance Through Sequential Mediation by Job Embeddedness and Burnout

Research assumes an effect of servant leadership on adaptive performance but has neglected the psychological processes underlying this link. Based on Social Exchange Theory and Job Demands–Resources Theory, this study sheds light on how servant leadership triggers job embeddedness, adaptive performance, and mitigates burnout. It also examines the mediating roles of job embeddedness and burnout between servant leadership and adaptive performance. We used three-wave data of 318 employees and their supervisors in the hospitality industry of Pakistan, applying structural equation modeling to examine six main effect hypotheses and three mediation hypotheses. Our findings suggest that servant leadership practices foster employees’ job embeddedness and adaptive performance, and mitigate burnout. Job embeddedness and burnout sequentially mediate the relationship between servant leadership and adaptive performance. Further unraveling the mechanisms between servant leadership and adaptive performance, this study implies that managers should recognize employee-perceived servant leadership as an influential factor that enhances engagement and well-being and ultimately the adaptive performance of their followers.
Deciphering Complex Interactions in Bioactive Lipid Signaling

Lipids are usually viewed as metabolic fuel and structural membrane components. Yet, in recent years, different families of lipids able to act as authentic messengers between cells and/or intracellularly have been discovered. Such lipid signals have been shown to exert their biological activity via specific receptors that, by triggering distinct signal transduction pathways, regulate manifold pathophysiological processes in our body. Here, endogenous bioactive lipids produced from arachidonic acid (AA) and other poly-unsaturated fatty acids will be presented, in order to put into better perspective the relevance of their mutual interactions for health and disease conditions. To this end, metabolism and signal transduction pathways of classical eicosanoids, endocannabinoids and specialized pro-resolving mediators will be described, and the intersections and commonalities of their metabolic enzymes and binding receptors will be discussed. Moreover, the interactions of AA-derived signals with other bioactive lipids such as shingosine-1-phosphate and steroid hormones will be addressed.
A Schur method for pole assignment

In this paper a new numerical algorithm for pole assignment of linear time-invariant systems is presented. The proposed algorithm uses reliable numerical techniques based on the Schur form of the state matrix and on the use of orthogonal transformations. Only the "bad" eigenvalues of the system are modified by a sequential pole-shifting procedure, and the resulted gains in the feedback matrix are minimized.
Lactoferrin, Osteopontin and Lactoferrin–Osteopontin Complex: A Critical Look on Their Role in Perinatal Period and Cardiometabolic Disorders

Milk-derived bioactive proteins have increasingly gained attention and consideration throughout the world due to their high-quality amino acids and multiple health-promoting attributes. Apparently, being at the forefront of functional foods, these bioactive proteins are also suggested as potential alternatives for the management of various complex diseases. In this review, we will focus on lactoferrin (LF) and osteopontin (OPN), two multifunctional dairy proteins, as well as to their naturally occurring bioactive LF–OPN complex. While describing their wide variety of physiological, biochemical, and nutritional functionalities, we will emphasize their specific roles in the perinatal period. Afterwards, we will evaluate their ability to control oxidative stress, inflammation, gut mucosal barrier, and intestinal microbiota in link with cardiometabolic disorders (CMD) (obesity, insulin resistance, dyslipidemia, and hypertension) and associated complications (diabetes and atherosclerosis). This review will not only attempt to highlight the mechanisms of action, but it will critically discuss the potential therapeutic applications of the underlined bioactive proteins in CMD.
Highlighting the potential of Synechococcus elongatus PCC 7942 as platform to produce α-linolenic acid through an updated genome-scale metabolic modeling

Cyanobacteria are prokaryotic organisms that capture energy from sunlight using oxygenic photosynthesis and transform CO2 into products of interest such as fatty acids. Synechococcus elongatus PCC 7942 is a model cyanobacterium efficiently engineered to accumulate high levels of omega-3 fatty acids. However, its exploitation as a microbial cell factory requires a better knowledge of its metabolism, which can be approached by using systems biology tools. To fulfill this objective, we worked out an updated, more comprehensive, and functional genome-scale model of this freshwater cyanobacterium, which was termed iMS837. The model includes 837 genes, 887 reactions, and 801 metabolites. When compared with previous models of S. elongatus PCC 7942, iMS837 is more complete in key physiological and biotechnologically relevant metabolic hubs, such as fatty acid biosynthesis, oxidative phosphorylation, photosynthesis, and transport, among others. iMS837 shows high accuracy when predicting growth performance and gene essentiality. The validated model was further used as a test-bed for the assessment of suitable metabolic engineering strategies, yielding superior production of non-native omega-3 fatty acids such as α-linolenic acid (ALA). As previously reported, the computational analysis demonstrated that fabF overexpression is a feasible metabolic target to increase ALA production, whereas deletion and overexpression of fabH cannot be used for this purpose. Flux scanning based on enforced objective flux, a strain-design algorithm, allowed us to identify not only previously known gene overexpression targets that improve fatty acid synthesis, such as Acetyl-CoA carboxylase and β-ketoacyl-ACP synthase I, but also novel potential targets that might lead to higher ALA yields. Systematic sampling of the metabolic space contained in iMS837 identified a set of ten additional knockout metabolic targets that resulted in higher ALA productions. In silico simulations under photomixotrophic conditions with acetate or glucose as a carbon source boosted ALA production levels, indicating that photomixotrophic nutritional regimens could be potentially exploited in vivo to improve fatty acid production in cyanobacteria. Overall, we show that iMS837 is a powerful computational platform that proposes new metabolic engineering strategies to produce biotechnologically relevant compounds, using S. elongatus PCC 7942 as non-conventional microbial cell factory.
Age matters: Life-stage, tissue, and sex-specific gene expression dynamics in Ips typographus (Coleoptera: Curculionidae: Scolytinae)

The Eurasian spruce bark beetle (ESBB), Ips typographus, has recently caused catastrophic damage to Norway spruce (Picea abies) forests in Europe, resulting in the loss of more than 100 million cubic meters of wood. Traditional forest management strategies have failed to constrain the growing infestation rate; hence, novel measures must be deployed. A better understanding of ESBB physiology and adaptation to host allelochemicals may provide a platform for future management strategies using molecular tools such as RNA interference. To understand ESBB physiology and adaptation, the current study unraveled the gene expression dynamics of ESBB in different life stages and tissues. We obtained ESBB transcriptomes for different life stages [larvae (L1, L2, and L3), pupa, callow, and sclerotized adult] and male/female tissues (gut, fat body, and head) from callow and sclerotized adult beetles. Differential gene expression analysis (DGE) identified multiple gene families related to detoxification, digestion, resistance, and transport in different life stages and tissues of the beetle. Gene Ontology (GO) enrichment revealed 61 critical metabolic pathways enriched across all DGE comparisons. DGE analysis further pinpointed the differential expression of essential genes involved in detoxification, digestion, transport, and defense in various tissues and life stages. RT-qPCR experiments and enzymatic assays corroborated the findings further. The catalogue of differentially expressed genes identified in ESBB could aid better understanding of ESBB physiology and adaptation to hosts and serve as targets for future RNAi-based ESBB management.
dc surface flashover mechanism along solids in vacuum based on a collision‐ionization model

Selected experimental results are presented from an extensive experimental investigation of dc prebreakdown and breakdown processes in vacuum along solid insulators made of a variety of alumina ceramics and polymers. The investigations included measurements of predischarge current, x‐ray intensity, insulator surface charge density, breakdown behavior as influenced by insulator surface characteristics and insulator profiles, and the analysis of the spectral characteristics associated with insulator surface luminescence. The prebreakdown and breakdown phenomena were found to be strongly influenced by surface microstructure and the chemical state of the insulator surface. The experimentally observed phenomena in our studies strongly point to a new breakdown model based on collision‐ionization by electrons of defect sites and/or traps within the dielectric subsurface at the vacuum interface.
A new proof of Gabriel's Lemma.

The technical result [2, Lemma 3.2] of Gabriel, called often Gabriel’s Lemma (for the precise formulation see Section 2), played a crucial role in proofs of two famous theorems in representation theory of algebras: the theorem of Gabriel on openness of the set of finite representation type algebras in a variety of all algebras with a fixed dimension (see [2]) and the Geiss Theorem saying that degeneration of a wild algebra is also wild (see [3]). The original proof of Gabriel’s Lemma is rather involved and uses geometry of schemes. An alternative proof, proposed by H. Kraft for the case of characteristic 0, applies essentially invariant theory and geometric quotients (see [5]). We present here a new, quite simple proof, which uses only basic projective geometry and adapts some arguments presented in [1].
Propriedades e aplicações dermatológicas das águas termais

As Aguas Minerais Naturais (aguas termais ou minero-medicinais) sao aguas subterrâneas localizados nas profundidades do subsolo, que, por este motivo, apresentam-se bacteriologicamente pura, sem necessitar de qualquer tratamento para essa purificacao. Assim, as aguas termais possuem caracteristicas fisico-quimicas tipicas de cada uma, variando de acordo com os fenomenos hidrogeologico. A presente pesquisa, tem por objetivo descrever as propriedade e aplicacoes das aguas termais na dermatologia, atraves de uma pesquisa bibliografica, utilizando como base de dados o google academico e o SciELO. As aguas termais apresentam uma composicao mineralogica rica e especifica, responsavel por seu potencial terapeutico, sendo indicada para prevencao e tratamento auxiliar de diversas condicoes dermatologicas como pele sensivel, dermatite de contato, dermatite seborreica, seborreia, acne, sebopsoriase, psoriase e ictiose, podendo ser utilizada em qualquer tipo de pele, ate mesmo naquelas que apresentam hipersensibilidade aos cosmeticos, isso porque, nao possuem efeitos secundarios aos terapeuticos, nao induzindo assim, reacoes inflamatorias. Estudos demostraram que os constituintes das aguas termais podem facilitar a hidratacao da pele, principalmente se tratando de peles secas, relatam ainda que os constituintes dessas aguas possuem acao anti-irritante, sendo eficiente na reducao de sinais clinicos provenientes de procedimentos dermatologicos ou de doencas dermatologicas. Atua tambem na normalizacao do pH da pele, principalmente das peles secas, contribuindo dessa forma para sua homeostasia. Outros estudos demostram, que as aguas termais apresentam propriedades anti-inflamatorias e imunomoduladoras, resultantes da interacao local entre os seus constituintes e a superficie cutânea, tambem evidenciam dispor de acao antioxidante, capaz de retardar o processo de envelhecimento cutâneo. Essas aguas, possuem tambem propriedades anti-seborreicas, que promove a limpeza da pele, colaborando para o cuidado das peles oleosas, reduzindo, assim, o excesso de sebo cutâneo que esta associado a algumas doencas dermatologicas, como a acne. Apresentam ainda, propriedades bactericidas e anti-fungicas, que estimulam um conjunto de mecanismos que dao origem a varias respostas imunologicas. Alem das propriedades citadas, essas aguas possuem ainda caracteristicas anti-pruriginosas e efeitos queratoplasticos/queratoliticos, sendo que este ultimo, alem de auxiliar no tratamento de algumas patologias dermatologicas, exerce tambem um efeito descamativo, comparando-o a um peeling superficial na pele.
Stress-associated weight gain, fibromyalgia symptoms, cardiometabolic markers, and human growth hormone suppression respond to an amino acid supplement blend: Results of a prospective, cohort study

Introduction An orally administered amino acid-based test supplement was recently shown to increase human growth hormone (hGH) in healthy adults. This prospective, observational, single-center, single-arm cohort study investigated the effects of 24 weeks of daily oral administration of the test supplement in individuals with stress-related weight gain, fibromyalgia (FM) and stress-related low-normal hGH production (15-30th percentile for age-appropriate levels) on insulin-like growth factor 1 (IGF-1), an indicator of hGH levels caused by stress related stimulation of somatostatin. Methods Participants continued to receive standard care. The primary endpoint was the change from baseline to endpoint (Week 24) in serum IGF-1. Additional endpoints included the change in body weight, clinical symptoms (assessed with the Revised Fibromyalgia Impact Questionnaire [FIQR], range 0-100, and Perceived Stress Scale [PSS], range 0-40), fasting cardiometabolic markers, tolerability, and safety. The study enrolled 84 fibromyalgia patients with low-normal age-adjusted IGF-1 serum levels. High mean ± Standard Deviation (SD) baseline FIQR and PSS scores of 76 ± 16 and 32 ± 5, respectively, indicated poor to moderate symptom management with standard care. All individuals completed 24 weeks. Results Serum IGF-1 levels increased with a Week 24 mean± Standard Error (SE) change of 28.4 ± 3.0 ng/mL (p<0.001). Body weight was reduced with a Week 24 mean ± SE change of -5.5 ± 0.3 kg (p<0.001) (a 6.5% weight loss from baseline). The change from baseline in FIQR and PSS scores were -29.1 ± 1.1 and -20.0 ± 0.8, respectively (both p<0.001), indicating a substantial improvement. Statistically significant improvements from baseline to Week 24 were observed in systolic and diastolic blood pressure, HbA1c, LDL and HDL cholesterol, and triglycerides (all p<0.001). The supplement was well tolerated; no adverse events were reported. Discussion Sustained augmentation of IGF-1 with the test supplement may represent a novel method of improving clinical symptoms, including stress-related weight gain, in individuals with fibromyalgia and stress-associated low-normal hGH.
On the Dynamics of Planetary Flow Regimes. Part II: Results from a Hierarchy of Orographically Forced Models

Abstract The relationship between steady states of the large-scale flow regimes revealed by multimodality in phase space and quasi-resonant axes of a linearized atmospheric model (neutral vectors) is investigated by means of a hierarchy of three hemispheric quasigeostrophic(QG) models, in which the flow is relaxed toward a zonally symmetric equilibrium state and orography provides the only source of asymmetric forcing. Two of these models describe only the interaction between the mean zonal flow and planetary waves of zonal wavenumber 3, including one or two meridional wavenumbers. The third model also has a zonal wavenumber-3 symmetry, but includes waves up to total wavenumber 21, and therefore is able to properly represent the interactions between planetary waves and baroclinically unstable synoptic-scale waves. Three stationary solutions are found for the highly truncated models, two of which represent states with large wave amplitude but opposite phase. These two steady states produce two well-defined.
La conservación de las aves en la era de la genómica

Las técnicas de secuenciación masiva o secuenciación de próxima generación han cambiado la forma de obtener datos genéticos para los estudios de conservación en aves, pasando del análisis de unos pocos loci ubicados en una pequeña porción del genoma a la obtención de información de cientos a miles de loci ubicados a lo largo de todo el genoma. Un mayor número de marcadores brinda más información para estudios filogenéticos, de introgresión y de estructuración poblacional, y permite una mejor estimación de los parámetros demográficos. Índices como la heterocigosis, el parentesco, la paternidad y la endogamia pueden ser estimados con mayor precisión. Además, uno de los mayores aportes de los estudios genómicos es la identificación de variación tanto adaptativa como neutra. En este trabajo se explica brevemente la base metodológica de la secuenciación masiva y se muestran ejemplos de la utilización de datos genómicos en estudios de conservación en aves.
Common Mental Disorders in Smart City Settings and Use of Multimodal Medical Sensor Fusion to Detect Them

Cities have undergone numerous permanent transformations at times of severe disruption. The Lisbon earthquake of 1755, for example, sparked the development of seismic construction rules. In 1848, when cholera spread through London, the first health law in the United Kingdom was passed. The Chicago fire of 1871 led to stricter building rules, which led to taller skyscrapers that were less likely to catch fire. Along similar lines, the COVID-19 epidemic may have a lasting effect, having pushed the global shift towards greener, more digital, and more inclusive cities. The pandemic highlighted the significance of smart/remote healthcare. Specifically, the elderly delayed seeking medical help for fear of contracting the infection. As a result, remote medical services were seen as a key way to keep healthcare services running smoothly. When it comes to both human and environmental health, cities play a critical role. By concentrating people and resources in a single location, the urban environment generates both health risks and opportunities to improve health. In this manuscript, we have identified the most common mental disorders and their prevalence rates in cities. We have also identified the factors that contribute to the development of mental health issues in urban spaces. Through careful analysis, we have found that multimodal feature fusion is the best method for measuring and analysing multiple signal types in real time. However, when utilizing multimodal signals, the most important issue is how we might combine them; this is an area of burgeoning research interest. To this end, we have highlighted ways to combine multimodal features for detecting and predicting mental issues such as anxiety, mood state recognition, suicidal tendencies, and substance abuse.
Characterization of Virulence Factors in Candida Species Causing Candidemia in a Tertiary Care Hospital in Bangkok, Thailand

Candidemia is often associated with high mortality, and Candida albicans, Candida tropicalis, Candida glabrata, and Candida parapsilosis are common causes of this disease. The pathogenicity characteristics of specific Candida spp. that cause candidemia in Thailand are poorly understood. This study aimed to characterize the virulence factors of Candida spp. Thirty-eight isolates of different Candida species from blood cultures were evaluated for their virulence properties, including exoenzyme and biofilm production, cell surface hydrophobicity, tissue invasion, epithelial cell damage, morphogenesis, and phagocytosis resistance; the identity and frequency of mutations in ERG11 contributing to azole-resistance were also determined. C. albicans had the highest epithelial cell invasion rate and phospholipase activity, with true hyphae formation, whereas C. tropicalis produced the most biofilm, hydrophobicity, protease activity, and host cell damage and true hyphae formation. ERG11 mutations Y132F and S154F were observed in all azole-resistant C. tropicalis. C. glabrata had the most hemolytic activity while cell invasion was low with no morphologic transition. C. glabrata was more easily phagocytosed than other species. C. parapsilosis generated pseudohyphae but not hyphae and did not exhibit any trends in exoenzyme production. This knowledge will be crucial for understanding the pathogenicity of Candida spp. and will help to explore antivirulence-based treatment.
Phonon-engineered mobility enhancement in the acoustically mismatched silicon/diamond transistor channels

The authors have shown that the low-field electron drift mobility in the ultrathin silicon films can be enhanced if they are embedded within acoustically hard materials such as diamond. The increase results from phonon spectrum modification in the acoustically mismatched silicon/diamond heterostructure and suppression of the deformation-potential electron-phonon scattering. The room temperature mobility in silicon films with 2 nm thickness can be increased by a factor of 2–3 depending on the hardness and thickness of the barrier layers. The obtained results suggest a new phonon-engineering approach for increasing the speed and drive current of downscaled electronic devices.
A robust sensor fault reconstruction scheme using sliding mode observers applied to a nonlinear aero-engine model

This paper describes the development and application of a robust fault reconstruction scheme to a nonlinear aeroengine model using a sliding mode observer. The fault reconstruction is obtained from scaling the so-called equivalent output error injection. The observer and the scaling are designed so that the L/sub 2/ gain from the system uncertainty to the fault reconstruction is minimised.
A new convective instability of the rotating-disk boundary layer with growth normal to the disk

In this paper we extend the familiar concept of spatial instability and growth of disturbances in the downstream direction to include spatial instability and growth in the wall-normal direction. The stability theory of boundary layers has generally been concerned with determining the evolution of disturbances inside a boundary layer (this is where disturbances have their largest amplitudes and can cause a laminar boundary layer to become turbulent). Outside a boundary layer, where the basic flow is uniform, normal-mode disturbances decay exponentially with distance from the wall to satisfy homogeneous boundary conditions. In this paper we present a surprising scenario where an impulsive disturbance, made up of a superposition of these normal modes, nonetheless grows exponentially with distance from the wall. While the usual convective instability with exponential growth in the downstream direction can be efficiently characterized by spatial modes with complex wavenumbers, the new convective instability can be efficiently characterized by modes with exponentially diverging ‘eigenfunctions’ obtained by moving certain branch-cuts in the complex wavenumber plane. The new instability is therefore associated with an interaction between the discrete spectrum and the continuous spectrum. We emphasize, however, that the homogeneous boundary conditions are always satisfied, and that at any finite time exponential growth only occurs over a finite distance from the wall, but this distance increases linearly with time. Interactions between poles and branch-cuts have been found before, but the results presented here provide a physical interpretation for this spectral behaviour. A further curiosity is that some of these divergent modes have been found to violate Howard's semi-circle theorem.