Miracle-dz/UniFAR-FTUs huggingface dataset:
Etude et mise en œuvre d’un banc intégré et étalonné 4 canaux pour la caractérisation temporelle de dispositifs non-linéaires hyperfréquences

Ce travail de cette these propose une conception et une realisation d’un banc integre de caracterisation temporelle des dispositifs RF non-lineaires concu avec des recepteurs de type THA. Ce banc est une version miniaturisee, moins onereuse et a performances comparables d’un banc similaire « eclate » et developpe au sein d’XLIM. Le banc integre developpe dans ce travail est entierement etalonne. Il est versatile vis-a-vis des techniques de sous echantillonnage mis en œuvre pour mesurer des signaux RF sur des temps d’acquisition tres differents (<50 µs ou < quelques ms). La technique CIS est utilisee pour l’acquisition periodiques de signaux RF periodiques de duree courtes. La technique DQD est utilisee pour l’acquisition periodiques ou aperiodique de signaux RF periodiques ou aperiodiques. Cet outil a ete utilise pour extraire, a partir des formes d’ondes temporelles mesurees a leurs acces, plusieurs parametres caracteristiques (AM/AM- AM/PM, EVM) d’amplificateurs GaN de gamme 10 a 50 W soumis a des excitations simples ou a des signaux modules. Ce manuscrit decrit aussi la mise en œuvre le developpement, parallelement au travail precedent, d’une plateforme de laboratoire de travaux pratiques a distance pour le projet europeen TEMPUS EOLES.
Recent Advances in Imaging Macular Atrophy for Late-Stage Age-Related Macular Degeneration

Age-related macular degeneration (AMD) is a leading cause of blindness worldwide. In late-stage AMD, geographic atrophy (GA) of dry AMD or choroidal neovascularization (CNV) of neovascular AMD eventually results in macular atrophy (MA), leading to significant visual loss. Despite the development of innovative therapies, there are currently no established effective treatments for MA. As a result, early detection of MA is critical in identifying later central macular involvement throughout time. Accurate and early diagnosis is achieved through a combination of clinical examination and imaging techniques. Our review of the literature depicts advances in retinal imaging to identify biomarkers of progression and risk factors for late AMD. Imaging methods like fundus photography; dye-based angiography; fundus autofluorescence (FAF); near-infrared reflectance (NIR); optical coherence tomography (OCT); and optical coherence tomography angiography (OCTA) can be used to detect and monitor the progression of retinal atrophy. These evolving diverse imaging modalities optimize detection of pathologic anatomy and measurement of visual function; they may also contribute to the understanding of underlying mechanistic pathways, particularly the underlying MA changes in late AMD.
Composite beads of silica gel, alginate and poly(aspartic acid) for the immobilization of a lipase enzyme

Silica gel/alginate/poly(aspartic acid) composite beads were prepared for immobilization of lipase B enzyme from Candida antarctica ( Ca LB). Ca LB was first adsorbed on functionalized mesoporous silica gel particles, which were then entrapped in the interpenetrating network of thiolated poly(aspartic acid) and alginate, cross-linked by zinc ions. Finally, the beads were chemically stabilized by poly(ethylene glycol) diglycidyl ether, a bisepoxide cross-linker. In this manner, spherical biocatalysts with a diameter of 3–4 mm were prepared and their biocatalytic performance was tested by kinetic resolution of racemic 1-phenylethanol. The activity of Ca LB in the beads was comparable to that of Ca LB physically adsorbed on silica gel particles. The composite beads were easy to recover after use and no loss of biocatalytic activity was observed even after five test reaction cycles. Furthermore, the Ca LB in the composite beads showed sufficient thermal stability up to 90°C, contrary to Ca LB adsorbed only on silica gel particles.
Epigenetic control and genomic imprinting dynamics of the Dlk1-Dio3 domain

Genomic imprinting is an epigenetic process whereby genes are monoallelically expressed in a parent-of-origin-specific manner. Imprinted genes are frequently found clustered in the genome, likely illustrating their need for both shared regulatory control and functional inter-dependence. The Dlk1-Dio3 domain is one of the largest imprinted clusters. Genes in this region are involved in development, behavior, and postnatal metabolism: failure to correctly regulate the domain leads to Kagami–Ogata or Temple syndromes in humans. The region contains many of the hallmarks of other imprinted domains, such as long non-coding RNAs and parental origin-specific CTCF binding. Recent studies have shown that the Dlk1-Dio3 domain is exquisitely regulated via a bipartite imprinting control region (ICR) which functions differently on the two parental chromosomes to establish monoallelic expression. Furthermore, the Dlk1 gene displays a selective absence of imprinting in the neurogenic niche, illustrating the need for precise dosage modulation of this domain in different tissues. Here, we discuss the following: how differential epigenetic marks laid down in the gametes cause a cascade of events that leads to imprinting in the region, how this mechanism is selectively switched off in the neurogenic niche, and why studying this imprinted region has added a layer of sophistication to how we think about the hierarchical epigenetic control of genome function.
Lecture : Stirring by swimming organisms

The question of which factors contribute to mixing in the ocean has been the subject of many studies. The idea that organisms could play a role in affecting their environment through something like mixing first appeared in Darwin’s last book, called “The formation of vegetable mould through the action of earth worms, with observations on their habits. ” (See figure 1.) This was suggested by his uncle and future father-in-law Josiah Wedgwood II, son of the famous potter. From Darwin’s book:
Genomic Selection in Rubber Tree Breeding: A Comparison of Models and Methods for dealing with G × E

Several genomic prediction models incorporating genotype × environment (G×E) interactions have recently been developed and used in genomic selection (GS) in plant breeding programs. G×E interactions decrease selection accuracy and limit genetic gains in plant breeding. Two genomic data sets were used to compare the prediction ability of multi-environment G×E genomic models and two kernel methods (a linear kernel (genomic best linear unbiased predictor, GBLUP) (GB) and a nonlinear kernel (Gaussian kernel, GK)) and prediction accuracy (PA) of five genomic prediction models: (1) one without environmental data (BSG); (2) a single-environment, main genotypic effect model (SM); (3) a multi-environment, main genotypic effect model (MM); (4) a multi-environment, single variance GxE deviation model (MDs); and (5) a multi-environment, environment-specific variance GxE deviation model (MDe). We evaluated the utility of GS with 435 rubber tree individuals in two sites and genotyped the individuals with genotyping-by-sequencing (GBS) of single-nucleotide polymorphisms (SNPs). Prediction models were estimated for diameter (DAP) and height (AP) at different ages, with a heritability ranging from 0.59 to 0.75 for both traits. Applying the model (BSG, SM, MM, MDs, and MDe) and kernel method (GBLUP and GK) combinations to rubber tree data showed that models with the nonlinear GK and linear GBLUP kernel had similar PAs. Multi-environment models were superior to single-environment genomic models regardless the kernel (GBLUP or GK), suggesting that introducing interactions between markers and environmental conditions increases the proportion of variance explained by the model and, more importantly, the PA. In the best scenario (well-watered (WW / GK), an increase of 6.7 and 8.7 fold of genetic gain can be obtained for AP and DAP, respectively, with multi-environment GS (MM, MDe and MDS) than by conventional genetic breeding model (CBM). Furthermore, GS resulted in a more balanced selection response in DAP and AP and if used in conjunction with traditional genetic breeding programs will contribute to a reduction in selection time. With the rapid advances in and declining costs of genotyping methods, balanced against the overall costs of managing large progeny trials and potential increased gains per unit time, we are hopeful that GS can be implemented in rubber tree breeding programs.
Immunopeptidomics in the Era of Single-Cell Proteomics

Simple Summary Fragments of pathogens, such as viruses and bacteria as well as cancer cells, are presented to the immune system via the major histocompatibility complex (MHC). Immunopeptidomics is a mass spectrometry-based technique that allows us to identify which peptide fragments of pathogens or aberrant mutated proteins are presented and potentially recognized by the immune system. Recent technological developments in mass spectrometry as well as sample preparation, peptide separation, and data analysis have substantially propelled the field of immunopeptidomics further and often initially were developed or incentivized for the measurement of single-cell proteomics. This perspective describes how developments in single-cell proteomics have benefitted immunopeptidomics and how further implementations could still boost sensitivity, and it will explore future directions and trends in immunopeptidomics. Abstract Immunopeptidomics, as the analysis of antigen peptides being presented to the immune system via major histocompatibility complexes (MHC), is being seen as an imperative tool for identifying epitopes for vaccine development to treat cancer and viral and bacterial infections as well as parasites. The field has made tremendous strides over the last 25 years but currently still faces challenges in sensitivity and throughput for widespread applications in personalized medicine and large vaccine development studies. Cutting-edge technological advancements in sample preparation, liquid chromatography as well as mass spectrometry, and data analysis, however, are currently transforming the field. This perspective showcases how the advent of single-cell proteomics has accelerated this transformation of immunopeptidomics in recent years and will pave the way for even more sensitive and higher-throughput immunopeptidomics analyses.
Heart Failure Promotes Cancer Progression in an Integrin β1-Dependent Manner

Heart failure and cancer are currently the deadliest diseases in the Western world, posing the most pressing clinical challenges that remain unmet today. Both conditions share similar risk factors, including age, genetics, lifestyle, chronic inflammation, stress, and more. Furthermore, medications that are being used to counteract cancer frequently result in cardiotoxicity and the spontaneous emergence of heart failure. Thus, heart failure and cancer display an intimate connection and share similarities. Recent studies show that cardiac remodeling and heart failure promote cancer progression and metastasis. Using three different mouse models for heart failure revealed that the communication between the remodeled heart and the tumor is facilitated through multiple secreted factors. Among these factors, Periostin was consistently found to be elevated in all models and was shown to be required in vitro. Yet, whether Periostin is necessary for tumor promotion in vivo is unknown. Towards this end, we examined tumor promotion in mice lacking Periostin following transverse aortic constriction (TAC). Despite the loss of Periostin, tumor growth was promoted in the TAC-operated mice. This likely occurred due to increased levels of various cytokines and growth factors in Periostin KO mice. Many of these factors are potential ligands of Integrin receptors. Therefore, we next studied the role of Integrin receptors in the tumor-promotion phenotype following heart failure. We generated cancer cells with an Integrin β1 loss of function mutation and examined tumor growth in the presence and absence of heart failure. Integrin β1 KO cancer cells fail to display cardiac-remodeling-dependent tumor-promotion. Interestingly, a previous study showed that renal cell carcinoma cells (Renca) fail to be promoted following a myocardial infarction. Consistently, we show that Renca cells do not respond to secreted factors derived from the failing heart both in vitro and in vivo. Interestingly, Renca cells display low basal mRNA levels of Integrin β1 which may explain the inability of heart failure to promote their growth. The findings may have significant clinical relevance to cardio–oncology patients who suffer from cancers with high levels of Integrin β1. Chemotherapy leading to cardiotoxicity in these patients may generate a vicious cycle with poor prognosis.
Improving the Electrical Conductivity of the Composite Comprising Bismuth Oxide, Activated Carbon, and Graphite for Use as a Battery Anode

This research is concerned with the synthesis and characterization of a composite material that may be used as a battery electrode. Bismuth oxide (Bi2O3) was synthesized from Bi(NO3)3·5H2O, Na2SO4, and NaOH mixed with commercial activated carbon and graphite. The composite formation process was carried out using the hydrothermal method at 110 °C for 5 h. The characterization data indicated the composites produced contained Bi2O3 with a monoclinic crystal system, and Bi2O3 particles were evenly distributed in the composite. The composites were characterized to be mesoporous, with the electrical conductivity reaching 10−1 S m−1. The development of this composite material has potential applications in the field of energy storage, particularly in the development of battery anode.
QUANTITATIVE AND QUALITATIVE STUDY OF THYMUS FALLAX ESSENTIAL OIL IN TWO HABITATS OF EAST AZARBAIJAN PROVINCE OF IRAN

ABSTRACT Essential oil analysis of Thymus fallax Fisch. &C.A. Mey for the first time was conducted in East Azerbaijan province in this study. The results show that quantitative oil yields between 0.53% to 0.91% respect to dry samples weight. Thymol (41.43 - 61.14 %), borneol (3.89 - 7.01 %), carvacrol (3.88- 6.5 %) and p-cymen (4.58 - 6 %) are the main compounds of essential oil in both sites. Keywords: Thymus fallax , essential oil, thymol, borneol, p-cymen
Pengaruh Pola Pemberian Nutrisi Terhadap Pertumbuhan Anak Ayam Broiler di Kecamatan Tembung, Kota Medan

Penelitian ini bertujuan untuk mengetahui pengaruh pola pemberian nutrien terhadap pertumbuhan ayam boiler yang diberi pakan selama 4 minggu dari umur 1 minggu terhadap kinerja pertumbuhan dan kadar lemak daging ayam broiler. Sebanyak 6 ekor ayam yang masing- masing dibagi menjadi 2 kelompok perlakuan yaitu 3 ekor ayam diberi pakan Beras dan 3 ekor ayam diberi pakan PUR. Metode Penelitian yang digunakan yaitu Eksperimen Kontrol Acak (Randomized Controlled Trial). Hasil dari ayam boiler yang diberi pakan beras mengalami pertumbuhan yang lumayan lama pada pertumbuhan bulu. Dibanding dengan hasil yang didapat pada ayam yang diberi pakan pur memiliki pertumbuhan yang sangat pesat. Interaksi perlakukan jenis pakan terhadap ayam boiler menunjukkan perbedaan nyata pada pertumbuhan dan perkembangan ayam boiler. Dari penelitian ini dapat disimpulkan bahwa, pemberian pakan beras terhadap 3 ekor ayam boiler mengalami penghambatan pertumbuhan daripada pemberian pakan PUR terhadap 3 ekor ayam boiler yang bertumbuh sangat pesat.
L'aquaculture en habitat artificiel (acadja-enclos) : Modifications et transformations du milieu lagunaire (lagune Tendo - Côte-d'Ivoire)

Cet article presente les resultats d'une etude comparative de sediments preleves en lagune et au sein de structures d'elevage de Poissons denommes «acadja-enclos» en experimentation a Tiapoum dans la lagune Tendo (Cote-d'Ivoire). Les caracteristiques biologiques (abondance et composition de la macrofaune benthique) et physico-chimiques ont permis de mettre en evidence de profonds changements du milieu au sein de la structure. Ces modifications correspondent essentiellement a une augmentation des fractions sedimentaires fines liees aux modifications de l'hydrodynamisme. Le nouveau biotope ainsi cree, plus confine, riche en matiere organique et en particules sedimentaires fines, favorise la proliferation des Mollusques brouteurs, des Polychetes et des Oligochetes. En conclusion, l'avenir de cette technique d'elevage extensif est discute et des recommandations sont formulees pour son usage dans les pays en voie de developpement.
Age dynamics of strain differences in the morphofunctional state of pancreatic beta- and amylin-producing cells in SHR and Wistar rats

Large-scale epidemiological studies have shown that cardiac pathology and progressive atherosclerosis in patients with diabetes mellitus occurred already at the stage of prediabetes. Obesity and insulin resistance affect cardiometabolic health due to pleiotropic effects of insulin. Despite the vast range of research, some aspects remain hidden links in the overall pathogenesis of metabolic and hemodynamic disorders. The aim of the work was to study the morphofunctional state of pancreatic islets (PIs), beta- and amylin-producing cells in male rats of Wistar strain (normotensive) and SHR (with spontaneous development of hypertension) in age dynamics. Materials and methods. The study was carried out using 38 male Wistar rats and SHRs aged 7 and 24 months. Non-invasive blood pressure (BP) detection procedures were done using the BP-2000 Blood Pressure Analysis System. The morphofunctional state of PIs was examined in serial 5-μm thick pancreatic tissue sections. Beta- and amylin-producing cells were detected after histological preprocessing and the use of monoclonal FITC-conjugated antibodies. Image file processing was done via ImageJ software (National Institutes of Health, USA). Levels of glycemia were monitored with a SUPER GLUCOCARD-II glucometer. Results. SHRs were hyperglycemic both at 7 and at 24 months, 8.41 ± 0.15 mmol/l and 8.90 ± 0.14 mmol/l, respectively, with elevated BP, 155 ± 5 / 80 ± 5 mm Hg and 165 ± 5 / 90 ± 5 mm, respectively. Old SHRs developed PI hypertrophy mainly associated with the increased number and percentage of beta-cells, apparently in response to hyperglycemia. Both in the PIs of adult and old SHRs, the number of amylin-producing cells was lower while the content of amylin was higher than those in the age-matched Wistar rats. Conclusions. Male SHRs are characterized by a persistent increase in blood pressure and abnormalities of carbohydrate metabolism already at adult age, one of the manifestations of which is hyperglycemia worsening with age. Chronic hyperglycemia in SHRs due to the higher insulin requirement finds its expression in low content of this hormone in the islets at adult age and decreased its content in beta-cells in old animals.
Siemens en el contexto de la Industria 4.0

Este trabajo tiene como objetivo analizar cuáles son algunas de las estrategias seguidas por el corporativo Siemens para ampliar tanto sus capacidades de aprendizaje como las ligadas a la innovación digital. Es un estudio de caso que documenta el por qué este corporativo es considerado como uno de los líderes tecnológicos en el contexto de la Industria 4.0. Con base en el resultado de la investigación se encuentra que esta empresa internacional, como parte de su estrategia, descentralizó muchas plantas ligadas a sus líneas de negocio fuera de Alemania y también llevó a cabo múltiples acuerdos de colaboración y join ventures. De igual forma, capacita de manera continua a su personal, establece nexos con instituciones educativas e impulsa internamente una cultura corporativa que facilita el aprendizaje laboral, la flexibilidad y su adaptación a los cambios del contexto.
Enhanced UV-B Radiation in Potato Stems and Leaves Promotes the Accumulation of Anthocyanins in Tubers

Enhanced ultraviolet-B (UV-B) radiation promotes anthocyanin biosynthesis in leaves, flowers and fruits of plants. However, the effects and underlying mechanisms of enhanced UV-B radiation on the accumulation of anthocyanins in the tubers of potatoes (Solanum tuberosum L.) remain unclear. Herein, reciprocal grafting experiments were first conducted using colored and uncolored potatoes, demonstrating that the anthocyanins in potato tubers were synthesized in situ, and not transported from the leaves to the tubers. Furthermore, the enhanced UV-B radiation (2.5 kJ·m−2·d−1) on potato stems and leaves significantly increased the contents of total anthocyanin and monomeric pelargonidin and peonidin in the red-fleshed potato ‘21-1’ tubers, compared to the untreated control. A comparative transcriptomic analysis showed that there were 2139 differentially expressed genes (DEGs) under UV-B treatment in comparison to the control, including 1724 up-regulated and 415 down-regulated genes. The anthocyanin-related enzymatic genes in the tubers such as PAL, C4H, 4CL, CHS, CHI, F3H, F3’5’H, ANS, UFGTs, and GSTs were up-regulated under UV-B treatment, except for a down-regulated F3’H. A known anthocyanin-related transcription factor StbHLH1 also showed a significantly higher expression level under UV-B treatment. Moreover, six differentially expressed MYB transcription factors were remarkably correlated to almost all anthocyanin-related enzymatic genes. Additionally, a DEGs enrichment analysis suggested that jasmonic acid might be a potential UV-B signaling molecule involved in the UV-B-induced tuber biosynthesis of anthocyanin. These results indicated that enhanced UV-B radiation in potato stems and leaves induced anthocyanin accumulation in the tubers by regulating the enzymatic genes and transcription factors involved in anthocyanin biosynthesis. This study provides novel insights into the mechanisms of enhanced UV-B radiation that regulate the anthocyanin biosynthesis in potato tubers.
THE IMPLEMENTATION OF INTERNET FINANCIAL REPORTING (IFR) IN INDONESIA: A SYSTEMATIC LITERATURE REVIEW

The implementation of Internet Financial Reporting (IFR) in Indonesia has emerged as a crucial area of emphasis in endeavors to enhance transparency and accountability in corporate financial reporting. It entails the promotion by regulatory and financial authorities to incentivize registered companies to electronically disclose their financial reports. The objective of this study is to enhance accessibility to company financial data, thereby benefiting stakeholders including investors, analysts, and the general public by making it more convenient and expeditious. The employed research methodology is Systematic Literature Review (SLR). The outcome is enhanced transparency and efficiency in the display of financial data, which has the potential to bolster stakeholder confidence. The implementation of IFR has demonstrated the significant advantages it offers in bolstering the expansion of the financial and investment industries in Indonesia. Nevertheless, the absence of International Financial Reporting (IFR) may restrict the availability of financial data, potentially diminishing stakeholder confidence, amplifying ambiguity, and impeding the expansion of the financial industry. Implementing IFR is crucial for fostering economic development and ensuring the integrity of capital markets in Indonesia. Through ongoing progress, it is anticipated that IFR will persist as the primary foundation for upholding transparency and efficiency in corporate financial reporting, rendering it a valuable resource in the rapidly advancing Indonesian economy.