Miracle-dz/UniFAR-FTUs huggingface dataset:
Repartnering of women in the United States: The interplay between motherhood and socio-economic status

We examine the socio-economic differentials in mothers’ and non-mothers’ repartnering behaviours following the dissolution of a co-residential (marital or cohabiting) union. Based on five waves of the National Survey of Family Growth (N = 11,479), we use discrete-time event history models, jointly modelling exit from a partnership and entry into a new union. Few differences are found for entry into direct marriage, which is a rarely observed event. However, when we examine women’s entry into cohabitation (a possible stepping stone to marriage), we observe: (1) a motherhood gap, where mothers are less likely to repartner than non-mothers; (2) a negative association between educational attainment and repartnering probability; and (3) the motherhood gap existing only for low-educated women. Supplementary analyses on the impact of the Great Recession demonstrate that whereas the economic cycle mattered for the repartnering of low-educated women, it made no difference for more highly educated women.
Appendectomy during pregnancy: rates, safety, and outcomes over a five-year period. A hospital-based follow-up study

Abstract Introduction Appendicitis is the most common acute abdominal complication during pregnancy. If appendix perforation occurs there is an increasing risk of preterm delivery and other pregnancy complications. Objective To assess the outcome of pregnancy after appendectomy, the mode of surgery used, appendectomy rates, and complications. Methods A prospective cohort study of pregnant women with, or without, appendectomy at South Stockholm General Hospital, December 2015 to February 2021 in a setting where pregnant women are prioritized for surgery and laparoscopic surgery was standard of care in first half of pregnancy. Data on preoperative imaging, surgical method, intraoperative findings, microscopic findings, hospital stay, pregnancy, and 30-day complications were prospectively recorded in a local appendectomy register. A non-pregnant control group was gathered comprising women of fertile age in the same study interval. Results During the study period 50 pregnant women, of whom 44 gave birth, underwent appendectomy of 38 199 women giving birth. There were no differences between women with or without appendectomy in proportion of preterm delivery (4.5% vs. 5.6%), small-for-gestational age (2.3% vs. 6.2%), or Cesarean delivery (18.2% vs. 20.4%). The rate of appendix perforation was 19% in non-pregnant control group compared to 12% among pregnancy. There was no case of perforated appendix in the second half of pregnancy. However, women with gestational age > 20 weeks more frequently had an unaffected appendix compared to those operated ≤ 20 gestational weeks (4/11 vs. 2/39, p = .005). Laparoscopic surgery was used in 97% of non-pregnant control group, 92% of appendectomies ≤ 20 weeks gestation, and in 27% >20 weeks. As compared to first half, the appendectomy rate was three times lower during the second half of pregnancy. Pregnant women had priority for surgery < 6 h compared to < 24 h among non-pregnant women, this resulted in a shorter time-to-surgery among pregnant women (p < .001) Conclusion Routine laparoscopic surgery and time priority for pregnant surgery is associated with a low risk of perforation, preterm birth and other complications. However, a low threshold for surgery may increase the risk of a negative exploration.
Left–Right‐Position, party affiliation and regional differences explain low COVID‐19 vaccination rates in Germany

Established vaccine hesitancy measurement instruments, such as the Vaccine Hesitancy Determinants Matrix, are not sufficiently equipped to adequately and consistently measure political and ideological attitudes. Focusing on Germany, which is a particularly interesting case since it witnessed the establishment of the by far most well‐organized and sustained ‘anti‐Covid’ movement in Europe, this quantitative study explores the impact of political ideology and partisanship on the degree of vaccine hesitancy based on four surveys (February—October 2021) among more than 30,000 individuals. We demonstrate that party affiliation, political ideology and region of residence all impact vaccine hesitancy. In fact, they turn out to have a greater impact than two factors often analysed with respect to vaccine hesitancy: gender and educational background. Further interaction models show that the effect of political ideology on vaccine hesitancy is moderated by age, gender and region of residency. For instance, while the more rightwing a young individual is, the more hesitant they are towards SARS‐CoV‐2 vaccination—for older individuals, this is not the case. Our findings are relevant for future investigators measuring vaccine hesitancy and policy makers contemplating the differential impact of complex public health interventions: as the impact of political and ideological attitudes on vaccine hesitancy are not adequately captured by established vaccine hesitancy measurement instruments, we recommend its modification to include a clear and harmonised definition of the political‐ideological dimension of vaccine hesitancy together with pre‐validated measurement items that improve future studies. In addition, we reason that vaccine hesitancy, while being an outcome of complex socio‐political factors, is in itself an indicator for societal cohesion and anomie, the degree of which is associated with trust in (health) policy makers, (public) health authorities, health service providers, etc. Therefore, we further recommend that vaccine hesitancy questions should be integrated in pertinent national surveys.
Exploring the Link between ADHD and Cannabis Use in Swedish Ninth Graders: The Role of Conduct Problems and Sensation-Seeking

Abstract Background: Attention deficit hyperactivity disorder (ADHD) has in several studies been linked to substance use, including cannabis use. However, crucial gaps remain regarding how to understand this association. Analyzing the association between ADHD and substance use is complicated because of a pronounced overlap between ADHD, conduct problems, and traits such as sensation-seeking. Objectives: Using data from a large and nationally representative study among Swedish adolescents, this study explored the role of conduct problems, but also of sensation-seeking, in accounting for the association between ADHD and cannabis use. Results: There was a notable association between ADHD and cannabis use that was attenuated when conduct problems were controlled for. The association between cannabis use and conduct problems, in turn, was attenuated when sensation-seeking was controlled for. Individuals with both ADHD and conduct problems were more likely to have used cannabis than individuals with ADHD only, but not compared with individuals with conduct problems only. Conclusions: Whereas conduct problems largely explain the link between ADHD and cannabis use, sensation-seeking seems to account for the association between conduct problems and cannabis use.
Mechanical response of GaN film and micropillar under nanoindentation and microcompression

The mechanical properties of GaN are examined by microcompression. The Young’s modulus and compressive yield stress in microscale are directly measured to be ∼226 and 10 GPa, comparable to the modulus (∼272 GPa) and hardness (15 GPa) measured by nanoindentation. The Raman spectrum measurements and transmission electron microscopy observations reveal that the residual stress in deposited film can be largely released in the form of micropillar. Upon microcompression, the strain energy is basically stored by dislocation and defect accumulation, with minimum residual stress regeneration. The small bending of the c-axis of the GaN micropillar upon compression would affect its optical performance.
The influence of post-etch InGaAs fin profile on electrical performance

The onset of the 22 nm node introduced three dimensional tri-gate transistors into high-volume manufacturing for improved electrostatics. The next generations of fin nMOSFETs are predicted to be InGaAs based. Due to the ternary nature of InGaAs, stoichiometric and structural modifications could affect the electronic properties of the etched fin. In this work we have created InGaAs fins down to 35 nm fin width with atomic surface structure kept nearly identical to that of the bulk. Our experimental and simulation results show the impact of surface stoichiometry and fin profile on electrical performance.
Actuating dielectric elastomers in pure shear deformation by elastomeric conductors

Pure shear experiments are commonly used to characterize dielectric elastomer (DE) material properties and to evaluate DE actuator/generator performance. It is increasingly important for many applications to replace conventional carbon grease electrodes with stretchable elastomeric conductors. We formulate a theory for DE with elastomeric conductors, synthesize transparent hydrogel as ionic conductors, and measure actuation of DE in pure shear deformation. Maximum 67% actuation strain is demonstrated. The theory agrees well with our measurement and also correlates well with reported experiments on DE with electronic conductors.
Has_circ_0048764 promotes breast cancer progression by sponging miR-578 and regulating HMGA2 expression

Abstract Background Circular RNAs (circRNAs) function as important regulators in the progression of cancers. The role of circRNA_0048764 (circ_0048764) in the development of breast cancer (BC) remains inconclusive. This work investigates the biological function and molecular mechanism of circ_0048764 in BC. Methods Quantitative real-time PCR (qRT-PCR) was conducted to measure the expression levels of circ_0048764, microRNA-578 (miR-578) and high mobility group AT-hook 2 (HMGA2) mRNA. The viability of BC cells was examined by cell counting kit 8 (CCK-8) assay. Besides, cyclin D1, proliferating cell nuclear antigen (PCNA) and HMGA2 expression levels were detected by western blot. The migrative and invasive capability of BC cells were probed by transwell assay. The relationships between miR-578 and circ_0048764 or HMGA2 3′-UTR were validated by dual-luciferase reporter gene assay. Results Circ_0048764 was highly expressed in BC tissues and cells, which was significantly associated with tumor size (≥2 cm), lymph node status (positive), and higher TNM stage of BC patients. Circ_0048764 depletion suppressed the proliferative, migrative, and invasive abilities of BC cells, which was rescued by transfection of miR-578 inhibitors. The binding sites were verified between circ_0048764 and miR-578. HMGA2 was identified to be a target of miR-578 in BC cells, and circ_0048764 positively regulated HMGA2 expression in BC cells via repressing miR-578. Conclusion Circ_0048764 promotes BC cell growth, migration and invasion via absorbing miR-578 and up-regulating HMGA2.
Plasmodium berghei Purified Hemozoin Associated with DNA Strongly Inhibits P. berghei Liver-Stage Development in BALB/c Mice after Intravenous Inoculation

In the acidic lysosome-like digestive vacuole, Plasmodium parasites crystallize heme from hemoglobin into hemozoin, or malaria pigment. Upon release of progeny merozoites, the residual hemozoin is phagocytized by macrophages principally in the liver and spleen where the heme crystals can persist for months to years, as heme oxygenase does not readily degrade the crystal. ABSTRACT In the acidic lysosome-like digestive vacuole, Plasmodium parasites crystallize heme from hemoglobin into hemozoin, or malaria pigment. Upon release of progeny merozoites, the residual hemozoin is phagocytized by macrophages principally in the liver and spleen where the heme crystals can persist for months to years, as heme oxygenase does not readily degrade the crystal. Previous studies demonstrated hemozoin modulation of monocytes and macrophages. Hemozoin modulates immune function activity of monocytes/macrophages. Here, we used purified/washed hemozoin (W-Hz) isolated from murine Plasmodium berghei infections and intravenously (i.v.) injected it back into naive mice. We characterized the modulating effect of W-Hz on liver-stage replication. Purified washed hemozoin decreases P. berghei liver levels both at 1 week and 1 month after i.v. injection in a dose and time dependent fashion. The injected hemozoin fully protected in nine out of 10 mice given a 50 sporozoite inoculum, and in 10 out of 10 mice against 2,000 sporozoites when they were infected an hour or a day after hemozoin inoculation. DNase treatment at the hemozoin reversed the observed liver load reduction. The liver load reduction was similar in mature B- and T-cell-deficient RAG-1 knockout (KO) mice suggesting an innate immune protection mechanism. This work indicates a role for residual hemozoin in down modulation of Plasmodium liver stages.
Pathogenesis of Bacterial Uveitis

ABSTRACT Purpose To describe the pathogenesis and the general immune mechanisms of the most frequent causes of bacterial uveitis. Methodology Narrative review Results Both extra- and intracellular bacteria can induce uveitis, whereas intracellular bacteria are generally transported into the inner eye via cells of the innate immune system, mainly macrophages. Systemic adaptive immunity is usually induced before the bacteria are localized to the inner eye, and once T and B cells have detected the pathogens behind the blood-eye barriers they elicit an acute and/or chronic inflammatory response deteriorating visual acuity that can severely affect the non-regenerating, intraocular tissues. Conclusions An understanding of pathogenic mechanisms, and its correlation with clinical and imaging features, can facilitate early recognition of microbial factors and institution of appropriate therapy.
X chromosome factor Kdm6a enhances cognition independent of its demethylase function in the aging XY male brain.

Males exhibit shorter lifespan and more cognitive deficits, in the absence of dementia, in aging human populations. In mammals, the X chromosome is enriched for neural genes and is a major source of biologic sex difference, in part, because males show decreased expression of select X factors (XY). While each sex (XX and XY) harbors one active X due to X chromosome inactivation in females, some genes, such as Kdm6a, transcriptionally escape silencing in females - resulting in lower transcript levels in males. Kdm6a is a known histone demethylase (H3K27me2/3) with multiple functional domains that is linked with synaptic plasticity and cognition. Whether elevating Kdm6a could benefit the aged male brain and whether this requires its demethylase function remains unknown. We used lentiviral-mediated overexpression of the X factor in the hippocampus of aging male mice and tested their cognition and behavior in the Morris water maze. We found that acutely increasing Kdm6a - in a form without demethylase function - selectively improved learning and memory, in the aging XY brain, without altering total activity or anxiety-like measures. Further understanding the demethylase-independent downstream mechanisms of Kdm6a may lead to novel therapies for treating age-induced cognitive deficits in both sexes.
CHARACTERISTICS OF WATER VAPOR OVER KITT-PEAK

Six years of spectroscopic measurements of the atmospheric line of H2O at 1.0832 μm are reported. The equivalent width of this line shows a stationary seasonal dependence corresponding to the range 4 to 27 mm precipitable water vapor in the monthly means. The extremes are 1.3 and 32 mm p.w. v. or a factor of 25. Inferred spectroscopic water vapor for Kitt Peak compares well with meteorological Rawinsonde data from nearby Tucson. The water vapor over certain other sites of current interest are then deduced from appropriate Rawinsonde records. A method for unblending a solar line contaminated by weak H2O blends is also given.
Burden of infectious disease studies in Europe and the United Kingdom: a review of methodological design choices

Abstract This systematic literature review aimed to provide an overview of the characteristics and methods used in studies applying the disability-adjusted life years (DALY) concept for infectious diseases within European Union (EU)/European Economic Area (EEA)/European Free Trade Association (EFTA) countries and the United Kingdom. Electronic databases and grey literature were searched for articles reporting the assessment of DALY and its components. We considered studies in which researchers performed DALY calculations using primary epidemiological data input sources. We screened 3053 studies of which 2948 were excluded and 105 studies met our inclusion criteria. Of these studies, 22 were multi-country and 83 were single-country studies, of which 46 were from the Netherlands. Food- and water-borne diseases were the most frequently studied infectious diseases. Between 2015 and 2022, the number of burden of infectious disease studies was 1.6 times higher compared to that published between 2000 and 2014. Almost all studies (97%) estimated DALYs based on the incidence- and pathogen-based approach and without social weighting functions; however, there was less methodological consensus with regards to the disability weights and life tables that were applied. The number of burden of infectious disease studies undertaken across Europe has increased over time. Development and use of guidelines will promote performing burden of infectious disease studies and facilitate comparability of the results.
Controlling Kinetic Pathways in Demixing Microgel–Micelle Mixtures

We investigate the temperature-dependent phase behavior of mixtures of poly(N-isopropylacrylamide) (pNIPAM) microgel colloids and a triblock copolymer (PEO–PPO–PEO) surfactant. Usually, gelation in these systems results from an increase in temperature. Here we investigate the role of the heating rate, and surprisingly, we find that this causes the mechanism of aggregation to change from one which is driven by depletion of the microgels by the micelles at low temperatures to the association of the two species at high temperatures. We thus reveal two competing mechanisms for attractions between the microgel particles which can be controlled by changing the heating rate. We use this heating-rate-dependent response of the system to access multiple structures for the same system composition. Samples were found to demix into phases rich and poor in microgel particles at temperatures below 33 °C, under conditions where the microgels particles are partially swollen. Under rapid heating full demixing is bypassed, and gel networks are formed instead. The temperature history of the sample, therefore, allows for kinetic selection between different final structures, which may be metastable.
Additional diagnoses in children with cleft lip and palate up to five years of age

Abstract Cleft lip and palate (CL/P) is the most common congenital craniofacial malformation and is often associated with additional diagnoses. The purpose of this study was to explore the cumulative five-year incidence of additional diagnoses for patients with cleft lip and palate. Further aims were, type of cleft and type of additional diagnose and to validate CLP registry data on additional diagnoses. Data from the CLP registry regarding children with CL/P in the Southern Health Care Region were retrieved and based on the registry, participants were selected. A review of medical records of participants born 2006–2016 was performed and data regarding participant characteristics and additional diagnoses were collected. Of the 250 participants included in the review of medical records, 90 participants (36%) had an additional diagnosis. Of the total number of identified additional diagnoses (n = 137), cardiovascular system (20.4%) and extremities and skeletal system (17.5%) were the most prevalent categories. The comparison between medical records and the CLP registry of all children showed a 14.4 percentage points higher incidence of additional diagnoses in the medical records. Roughly every third child received an additional diagnosis and diagnoses related to the cardiovascular system were the most frequent. This study also shows that additional diagnoses were under-reported in the CLP registry. Future research is necessary to strengthen associations of additional diagnoses to CL/P.
Cohomology of the Moduli Space of Cubic Threefolds and Its Smooth Models

We compute and compare the (intersection) cohomology of various natural geometric compactifications of the moduli space of cubic threefolds: the GIT compactification and its Kirwan blowup, as well as the Baily–Borel and toroidal compactifications of the ball quotient model, due to Allcock–Carlson–Toledo. Our starting point is Kirwan’s method. We then follow by investigating the behavior of the cohomology under the birational maps relating the various models, using the decomposition theorem in different ways, and via a detailed study of the boundary of the ball quotient model. As an easy illustration of our methods, the simpler case of the moduli space of cubic surfaces is discussed in an appendix.
Energy growth in viscous channel flows

In recent work it has been shown that there can be substantial transient growth in the energy of small perturbations to plane Poiseuille and Couette flows if the Reynolds number is below the critical value predicted by linear stability analysis. This growth, which may be as large as O(1000), occurs in the absence of nonlinear effects and can be explained by the non-normality of the governing linear operator - that is, the non-orthogonality of the associated eigenfunctions. In this paper we study various aspects of this energy growth for two- and three-dimensional Poiseuille and Couette flows using energy methods, linear stability analysis, and a direct numerical procedure for computing the transient growth. We examine conditions for no energy growth, the dependence of the growth on the streamwise and spanwise wavenumbers, the time dependence of the growth, and the effects of degenerate eigenvalues. We show that the maximum transient growth behaves like O(R2), where R is the Reynolds number. We derive conditions for no energy growth by applying the Hille–Yosida theorem to the governing linear operator and show that these conditions yield the same results as those derived by energy methods, which can be applied to perturbations of arbitrary amplitude. These results emphasize the fact that subcritical transition can occur for Poiseuille and Couette flows because the governing linear operator is non-normal.