Miracle-dz/UniFAR-FTUs huggingface dataset:
Difference and Analysis of Evaluating Psychological Monitors' Interview and Classmates' Being Interviewed About Suicide

In recent years, suicide has become the leading cause of unnatural death among college students in China. Psychological monitors, as class cadres who manage affairs related to mental health within their classes, are critical in identifying and intervening in psychological crises among their classmates. In China, however, talking about death is a cultural taboo, and many mental health workers have expressed concern about their implementation of interviews about suicide with others. Generally speaking, interviews with suicidal classmates are usually conducted by professional psychological experts and psychological monitors (psychological monitors are non-professional peer counselors in China). Such classmates that have undergone both the aforementioned types of interviews were investigated in this paper. However, this paper focuses on two issues. Firstly, what are the perceptions of classmates who have been interviewed toward the experience of being interviewed by psychological monitors? Secondly, what are the psychological monitors' perceptions of their implementation of interviews about suicide with classmates? In this study, 1,664 classmates who had been interviewed and 1,320 psychological monitors were surveyed by means of an online questionnaire. The results showed that classmates who have been interviewed perceived their experience of being interviewed by a psychological monitor about suicide more positively than the psychological monitors who viewed their implementation of interviews about suicide with classmates. Among the classmates who have been interviewed, three categories of classmates have more positive perceptions of their experience of being interviewed by a psychological monitor about suicide. Category one is males. Category two is those who were willing to seek help from the psychological monitors. Category three is those who had a more correct attitude toward mental illness. Among the psychological monitors, three categories of psychological monitors have more positive perceptions of their implementation of interviews about suicide with classmates. Category one is those who have the experience of implementing interviews with their classmates. Category two is those who have received training. Category three is those who had a more correct attitude toward mental illness. Psychological monitors can interview classmates confidently, and the training of psychological monitors on mental health knowledge should be strengthened in universities.
Quiescent radio emission in UX Arietis

Multifrequency observations of the quiescent radio emission of UX Arietis performed with the 100 m radio telescope of Effelsberg are reported. The derived spectral index α = 0.2 (S v ∞ v −α ) implies that besides the flaring emission also the quiescent one is due to electrons with a power-law energy distribution. A lower limit estimate of the life time of the quiescent emission imposes the following constraints on magnetic field and thermal electron density : B ≤ 30 G, N e < 4 10 7 cm −3 . The present data are insufficient to distinguish if the emitting electrons are produced during a flare or if a continuous injection of particles must be invoked
La Evolución en los Estudios Anatómicos en Venezuela durante el Siglo XIX

Para Venezuela el siglo XIX representó una época de reformas socio-económicas y políticas, complicadas en guerras y revoluciones. En esta circunstancia, el crecimiento de la actividad económica fue lento e inconstante. Los estándares de vida de la población apenas superaron el nivel de subsistencia, con un déficit persistente en el gasto educativo. En circunstancias adversas, la reforma en los estudios anatómicos en Venezuela durante el siglo XIX, se desarrolló en buena parte a la constante labor de un conjunto de perseverantes anatomistas venezolanos. Entre ellos destaca José María Vargas, reformador de los estudios médicos, quien escribió en 1838 Curso de Lecciones y demostraciones Anatómicas, el primer libro en esta materia impreso en Venezuela.
Individual diferences in emotion regulation moderate the associations between empathy and afective distress

Individual diferences in empathy can have positive and negative psychological outcomes. Yet, individual diferences in the processing and regulation of empathy-induced emotion have not been fully explored within this dynamic. This study was designed to explore whether individual diferences in emotion regulation strategies moderated the efects of empathy on common forms of afective distress. Eight hundred and forty four participants completed survey measures of trait empathy, emotion regulation strategies, and symptoms of depression, anxiety, and stress. Afective empathy typically predicted greater afective distress, but the efects on depression and anxiety were ofset when people were efective at reappraising their emotions. Cognitive empathy predicted lower distress on average, but this beneicial efect on anxiety and stress was absent in those who typically suppressed their emotions. Finally, suppression unexpectedly reduced the depression and stress reported for people high in afective empathy. Individual diferences in emotion regulation are an important moderator between empathy and psychological health, and thus a useful target for intervention.
Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Aloin Against Gastric Cancer

Purpose This study was designed to evaluate the pharmacological mechanisms of Aloin against gastric cancer (GC) via network pharmacology analysis combined with experimental verification. Methods Using network pharmacology methods, the potential targets of Aloin and targets related to GC were screened from public databases. The protein–protein interaction (PPI) network, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed to predict the core targets and pathways of Aloin against GC. The expressions of major targets predicted by network pharmacology in normal stomach tissues and GC tissues and their relationships with overall survival of GC were searched in GEPIA, HPA and DriverDBv3 database. The results of network pharmacology analysis were verified by in vitro experiments. Results A total of 129 potential targets were retrieved by searching the intersection of Aloin and GC targets. PPI network analysis indicated that 10 targets, including AKT1 and CASP3, were hub genes. GO enrichment analysis involved 93 biological processes, 19 cellular components, and 37 molecular functions. KEGG enrichment analysis indicated that the anti-cancer effect of Aloin was mediated through multiple pathways, such as PI3K-AKT, FoxO and Ras signaling pathway. Among them, the PI3K-AKT signaling pathway, which contained the largest number of enriched genes, may play a greater role in the treatment of GC. The validation of key targets in GEPIA, HPA and DriverDBv3 database showed that the verification results for most core genes were consistent with this study. Then, the results of in vitro experiment indicated that Aloin could inhibit proliferation of NCI-N87 cells and induce cell apoptosis. The results also showed that Aloin could decrease the mRNA and protein expressions of PI3K and AKT, suggesting that Aloin can treat GC by inducing cell apoptosis and regulating the PI3K-AKT signaling pathway. Conclusion This study identified the potential targets of Aloin against GC using network pharmacology and in vitro verification, which provided a new understanding of the pharmacological mechanisms of Aloin in treatment of GC.
Detection of supercooled liquid water containing clouds with ceilometers: development and evaluation of deterministic and data-driven retrievals

Abstract. Cloud and aerosol lidars measuring backscatter and depolarization ratio are the most suitable lidars to detect cloud phase (liquid, ice, or mixed phase). However, such instruments are not widely deployed as part of operational networks. In this study, we propose a new algorithm to detect supercooled liquid water containing clouds (SLCC) based on ceilometers measuring only co-polarization backscatter. We utilize observations collected at Davis, Antarctica, where low-level, mixed-phase clouds, including supercooled liquid water (SLW) droplets and ice crystals, remain poorly understood due to the paucity of ground-based observations. A 3-month set of observations were collected during the austral summer of November 2018 to February 2019, with a variety of instruments including a depolarization lidar and a W-band cloud radar which were used to build a two-dimensional cloud phase mask distinguishing SLW and mixed-phase clouds. This cloud phase mask is used as the reference to develop a new algorithm based on the observations of a single polarization ceilometer operating in the vicinity for the same period. Deterministic and data-driven retrieval approaches were evaluated: an extreme gradient boosting (XGBoost) framework ingesting backscatter average characteristics was the most effective method at reproducing the classification obtained with the combined radar–lidar approach with an accuracy as high as 0.91. This study provides a new SLCC retrieval approach based on ceilometer data and highlights the considerable benefits of these instruments to provide intelligence on cloud phase in polar regions that usually suffer from a paucity of observations. Finally, the two algorithms were applied to a full year of ceilometer observations to retrieve cloud phase and frequency of occurrences of SLCC: SLCC was present 29 ± 6 % of the time for T19 and 24 ± 5 % of the time for G22-Davis over that annual cycle.
Cytotoxicity of 9,10-Phenanthrenequinone Impairs Mitotic Progression and Spindle Assembly Independent of ROS Production in HeLa Cells

The polycyclic aromatic hydrocarbon quinone derivative 9,10-phenanthrenequinone (9,10-PQ) is one of the most abundant and toxic components found in diesel exhaust particles (DEPs). These DEPs are created during diesel fuel combustion and are considered the main source of urban air pollution. As 9,10-PQ can produce excessive reactive oxygen species (ROS) through redox cycling, it has been shown to exert potent cytotoxic effects against various cell types. However, the mechanisms underlying this cytotoxicity remain unclear. In this study, we showed that 9,10-PQ exerts cytotoxicity by impairing mitotic progression and spindle assembly in HeLa cells. Exposure to 9,10-PQ impaired spindle assembly and chromosome alignment, resulting in delayed mitotic entry and progression in HeLa cells. Furthermore, 9,10-PQ exposure decreased the CEP192 and p-Aurora A levels at the spindle poles. Notably, these mitotic defects induced by 9,10-PQ were not rescued by scavenging ROS, implying the ROS-independent activity of 9,10-PQ. Therefore, our results provide the first evidence that 9,10-PQ exerts its cytotoxicity through specific inhibition of mitotic progression and spindle assembly, independent of ROS.
VCNet: Hybrid Deep Learning Model for Detection and Classification of Lung Carcinoma Using Chest Radiographs

Detection of malignant lung nodules from Computed Tomography (CT) images is a significant task for radiologists. But, it is time-consuming in nature. Despite numerous breakthroughs in studies on the application of deep learning models for the identification of lung cancer, researchers and doctors still face challenges when trying to deploy the model in clinical settings to achieve improved accuracy and sensitivity on huge datasets. In most situations, deep convolutional neural networks are used for detecting the region of the main nodule of the lung exclusive of considering the neighboring tissues of the nodule. Although the accuracy achieved through CNN is good enough but this models performance degrades when there are variations in image characteristics like: rotation, tiling, and other abnormal image orientations. CNN does not store relative spatial relationships among features in scanned images. As CT scans have high spatial resolution and are sensitive to misalignments during the scanning process, there is a requirement of a technique which helps in considering spatial information of image features also. In this paper, a hybrid model named VCNet is proposed by combining the features of VGG-16 and capsule network (CapsNet). VGG-16 model is used for object recognition and classification. CapsNet is used to address the shortcomings of convolutional neural networks for image rotation, tiling, and other abnormal image orientations. The performance of VCNeT is verified on the Lung Image Database Consortium (LIDC) image collection dataset. It achieves higher testing accuracy of 99.49% which is significantly better than MobileNet, Xception, and VGG-16 that has achieved an accuracy of 98, 97.97, and 96.95%, respectively. Therefore, the proposed hybrid VCNet framework can be used for the clinical purpose for nodule detection in lung carcinoma detection.
Cross Analysis of Genomic-Pathologic Features on Multiple Primary Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is a prevalent malignancy cancer worldwide with a poor prognosis. Hepatic resection is indicated as a potentially curative option for HCC patients in the early stage. However, due to multiple nodules, it leads to clinical challenges for surgical management. Approximately 41%–75% of HCC cases are multifocal at initial diagnosis, which may arise from multicentric occurrence (MO-HCC) or intrahepatic metastasis (IM-HCC) pattern with significantly different clinical outcomes. Effectively differentiating the two mechanisms is crucial to prioritize the allocation of surgery for multifocal HCC. In this study, we collected a multifocal hepatocellular carcinoma cohort of 17 patients with a total of 34 samples. We performed whole-exome sequencing and staining of pathological HE sections for each lesion. Reconstruction of the clonal evolutionary pattern using genome mutations showed that the intrahepatic metastogenesis pattern had a poorer survival performance than independent origins, with variants in the TP53, ARID1A, and higher CNV variants occurring more significantly in the metastatic pattern. Cross-modality analysis with pathology showed that molecular classification results were consistent with pathology results in 70.6% of patients, and we found that pathology results could further complement the classification for undefined patterns of occurrence. Based on these results, we propose a model to differentiate the pattern of multifocal hepatocellular carcinoma based on the pathological results and genome mutations information, which can provide guidelines for diagnosing and treating multifocal hepatocellular carcinoma.
Invader at the edge — Genomic origins and physiological differences of round gobies across a steep urban salinity gradient

Species invasions are a global problem of increasing concern, especially in highly connected aquatic environments. Despite this, salinity conditions can pose physiological barriers to their spread, and understanding them is important for management. In Scandinavia's largest cargo port, the invasive round goby (Neogobius melanostomus) is established across a steep salinity gradient. We used 12,937 SNPs to identify the genetic origin and diversity of three sites along the salinity gradient and round goby from western, central and northern Baltic Sea, as well as north European rivers. Fish from two sites from the extreme ends of the gradient were also acclimated to freshwater and seawater, and tested for respiratory and osmoregulatory physiology. Fish from the high‐salinity environment in the outer port showed higher genetic diversity, and closer relatedness to the other regions, compared to fish from lower salinity upstream the river. Fish from the high‐salinity site also had higher maximum metabolic rate, fewer blood cells and lower blood Ca2+. Despite these genotypic and phenotypic differences, salinity acclimation affected fish from both sites in the same way: seawater increased the blood osmolality and Na+ levels, and freshwater increased the levels of the stress hormone cortisol. Our results show genotypic and phenotypic differences over short spatial scales across this steep salinity gradient. These patterns of the physiologically robust round goby are likely driven by multiple introductions into the high‐salinity site, and a process of sorting, likely based on behaviour or selection, along the gradient. This euryhaline fish risks spreading from this area, and seascape genomics and phenotypic characterization can inform management strategies even within an area as small as a coastal harbour inlet.
Structuring general and complete quantum computations in Haskell : the arrows approach

10 RESUMO . 11
TCRM_A_199440 627..635

Lei Wan Liu-Jia-Zi Shao Yang Liu Hai-Xia Wang Fu-Shan Xue Ming Tian 1Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China Purpose: This study aimed to assess the effect of intravenous dexmedetomidine (DEX) on sevoflurane EC50 for supraglottic airway device (SAD) insertion in spontaneously breathing morbidly obese patients. Patients and methods: Thirty-eight morbidly obese patients with a body mass index 40–57 kg/m who were scheduled for bariatric surgery under general anesthesia requiring tracheal intubation were randomly allocated to two groups receiving the different treatments: group S, saline was given intravenously, and group D, a bolus dose of DEX 1 μg/kg was administered intravenously over 10 mins, followed by intravenous DEX infusion at a rate of 0.5 μg/kg/h. Five percent sevoflurane was initially inhaled for anesthesia induction and then end-tidal expiratory sevoflurane concentration (ETsev) was adjusted to a target value as to the modified Dixon’s up-and-down method. Patients’ response to SAD insertion was classified as “movement” or “no movement”. The average of the midpoints of all crossover points was defined as calculated sevoflurane EC50 for successful SAD insertion. Furthermore, the probit regression analysis was used to determine sevoflurane end-tidal concentrations where 50% (EC50) and 95% (EC95) insertions of SAD were successful. After the observation was completed, flexible bronchoscope-guided intubation was performed through the SAD. Results: The calculated sevoflurane EC50 for successful SAD insertion was significantly lower in group D than in group S (1.75±0.32% vs 2.92±0.26%, p<0.001). By the probit regression analysis, EC50 and EC95 of sevoflurane for successful SAD insertion were 1.59% (95% CI, 1.22–1.90%) and 2.15% (95% CI, 1.86–3.84%) in group D, respectively, and 2.81% (95% CI, 2.35–3.29%) and 3.32% (3.02–6.74%) in group S. Conclusion: When sevoflurane inhalational induction is performed in spontaneous breathing morbidly obese patients, intravenous DEX can reduce sevoflurane EC50 for successful SAD insertion by about 40%. Chinese Clinical Trial Registry: No. ChiCTR1800016868
Excess Mortality Attributable to Hospital-Acquired Antimicrobial-Resistant Infections: A 2-Year Prospective Surveillance Study in Northeast Thailand

Abstract Background Quantifying the excess mortality attributable to antimicrobial-resistant (AMR) bacterial infections is important for assessing the potential benefit of preventive interventions and for prioritization of resources. However, there are few data from low- and middle-income countries. Methods We conducted a 2-year prospective surveillance study to estimate the excess mortality attributable to AMR infections for all types of hospital-acquired infection (HAI), and included bacterial species that were both locally relevant and included in the World Health Organization priority list. Twenty-eight-day mortality was measured. Excess mortality and population attributable fraction (PAF) of mortality caused by AMR infections compared to antimicrobial-susceptible (AMS) infections, adjusted for predefined confounders, were calculated. Results We enrolled 2043 patients with HAIs. The crude 28-day mortality of patients with AMR and AMS infections was 35.5% (491/1385) and 23.1% (152/658), respectively. After adjusting for prespecified confounders, the estimated excess mortality attributable to AMR infections was 7.7 (95% confidence interval [CI], 2.2–13.2) percentage points. This suggests that 106 (95% CI, 30–182) deaths among 1385 patients with AMR infections might have been prevented if all of the AMR infections in this study were AMS infections. The overall PAF was 16.3% (95% CI, 1.2%–29.1%). Among the bacteria under evaluation, carbapenem-resistant Acinetobacter baumannii was responsible for the largest number of excess deaths. Among all types of infection, urinary tract infections were associated with the highest number of excess deaths, followed by lower respiratory tract infections and bloodstream infections. Conclusions Estimating and monitoring excess mortality attributable to AMR infections should be included in national action plans to prioritize targets of preventive interventions. Clinical Trials Registration NCT03411538.
Supercapacitor performance based on nitrogen and sulfur co‐doped hierarchically porous carbons: Superior rate capability and cycle stability

Herein, the banana‐peel waste was carbonized followed by KOH activation to design novel N, S‐co‐doped hierarchically porous carbonaceous materials (NS‐AC). The synthesized sample (NS‐AC) exhibited an interconnected porosity and endowed with a high specific surface area (SSA ~ 2452 m2 g−1), total pore volume (Vtotal ~ 1.82 cm3 g−1), and moderate nitrogen (3.2 at%) and sulfur (0.6 at%) contents. Moreover, these carbons, when scrutinized as electrode materials, demonstrated a specific capacitance (220 F g−1 at 0.5 A g−1), which persists at 145 F g−1 even at a large current density of 6 A g−1, thereby demonstrating an efficient rate capability. Furthermore, a capacitance retention of ~78.2% over 15 000 cycles was also observed. All these characteristics reveal NS‐AC carbons a promising contender for energy storage. Finally, as‐prepared symmetric supercapacitor (NS‐AC/NS‐AC) exhibited remarkable energy density ~5.3 Wh kg−1 at a power density of 2690 W kg−1 with capacitance retention of 88% over 4000 charge/discharge cycles, which surpasses the working performance of the many reported carbon materials obtained from biomass sources. In conclusion, outstanding textural features and enhanced conductivity by KOH activation, in addition to the improved surface wettability posed by N‐ and S‐enriched surfaces, resulted in considerable supercapacitor performance.
Improving ecosystem services in farmlands: beginning of a long-term ecological study with restored flower-rich grasslands

ABSTRACT Biodiversity declines in an unprecedented way, mostly due to land use change. Restoration interventions proved to be one of the most effective tools to halt the decline, especially in ecosystems such as agricultural fields. Evidence-based, locally adapted recommendations on grassland restoration, however, are often missing, so we present a novel approach for such interventions that can be implemented anywhere and that are based on scientific rigor. In a recently started long-term field ecological study, we established 0.5 ha wildflower parcels, using a diverse local seed mixture of 32 insect-visited plant species in Central European agricultural landscapes in 2020. Our focus is on the landscape-scale effects of this ecological intensification on ecosystem services such as crop yield, pollination and pest control, and the long-term monitoring of the successional processes. The aim is to showcase an effective restoration protocol that could serve as a model for future farm management, and provide much-needed evidence for policy on landscape ecological restoration of international relevance.