Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of the Electrode Montage to Detect Ocular Vestibular Evoked Myogenic Potentials

Objective To compare ocular vestibular evoked myogenic potentials (oVEMPs) obtained with three different electrode montages (infra-orbital vs belly-tendon vs chin) in a group of healthy subjects. To assess the electrical activity recorded at the level of the reference electrode in the belly-tendon and chin montages. Study Design Prospective study. Setting Tertiary referral center. Patients Twenty-five healthy adult volunteers. Intervention(s) Each ear was tested separately via air-conducted sound (500 Hz Narrow Band CE-Chirps at 100 dB nHL) for recording contralateral myogenic responses. Recording conditions were randomized. Main Outcome Measure(s) n1-p1 amplitudes values, interaural amplitude asymmetry ratios (ARs) and response rates. Results The belly-tendon electrode montage (BTEM) produced larger amplitudes than the chin (p = 0.008) and the IOEM (infra-orbital electrode montage; p < 0.001). The chin montage displayed larger amplitudes than the IOEM (p < 0.001). The interaural amplitude asymmetry ratios (ARs) were not affected by the different electrode montages (p = 0.549). In 100% of cases, oVEMPs were detected bilaterally with the BTEM which is higher than with the chin and the IOEM (p < 0.001; p = 0.020, respectively). We did not record any VEMP when placing the active electrode on the contralateral internal canthus or the chin and the reference electrode on the dorsum of the hand. Conclusions The BTEM increased the amplitudes recorded and response rate in healthy subjects. No positive or negative reference contamination was observed with the belly-tendon or chin montages.
An Accurate and Inter-Operatable Fuzzy-Based System Using Genetic and Canonical Correlation Analysis Methods in Internet-of-Brain Things

The brain computer interface is defined as the way of acquiring the brain signals that analyse and translates them into commands that are relayed to intelligent devices for carrying out various actions. Through number of BCI mechanism and approaches have been proposed by various scientists to empower the individuals for directly controlling their objects via their thoughts. However, the actual implementation and realization of this method faces number of challenging with low accuracy and less interoperability. In addition, the pre-processing signals and feature extraction process is further time consuming and less accurate. In order to overcome the mentioned issues, this paper proposes an accurate and highly inter-operable system using genetic fuzzy system along. The predictive model and analysis can be further improved using canonical correlation analysis. The proposed framework is validated and demonstrated using brain typing system analysis. The results are computed against accuracy, latency and interoperability of the signals received from brain with less SNR along with traditional method. The proposed mechanism shows approximately 87% improvement as compare to existing approaches during the simulation over various performance metrics.
Neurovascular Uncoupling Is Linked to Microcirculatory Dysfunction in Regions Outside the Ischemic Core Following Ischemic Stroke

Background Normal brain function depends on the ability of the vasculature to increase blood flow to regions with high metabolic demands. Impaired neurovascular coupling, such as the local hyperemic response to neuronal activity, may contribute to poor neurological outcome after stroke despite successful recanalization, that is, futile recanalization. Methods and Results Mice implanted with chronic cranial windows were trained for awake head‐fixation before experiments. One‐hour occlusion of the anterior middle cerebral artery branch was induced using single‐vessel photothrombosis. Cerebral perfusion and neurovascular coupling were assessed by optical coherence tomography and laser speckle contrast imaging. Capillaries and pericytes were studied in perfusion‐fixed tissue by labeling lectin and platelet‐derived growth factor receptor β. Arterial occlusion induced multiple spreading depolarizations over 1 hour associated with substantially reduced blood flow in the peri‐ischemic cortex. Approximately half of the capillaries in the peri‐ischemic area were no longer perfused at the 3‐ and 24‐hour follow‐up (45% [95% CI, 33%–58%] and 53% [95% CI, 39%–66%] reduction, respectively; P<0.0001), which was associated with contraction of an equivalent proportion of peri‐ischemic capillary pericytes. The capillaries in the peri‐ischemic cortex that remained perfused showed increased point prevalence of dynamic flow stalling (0.5% [95% CI, 0.2%–0.7%] at baseline, 5.1% [95% CI, 3.2%–6.5%] and 3.2% [95% CI, 1.1%–5.3%] at 3‐ and 24‐hour follow‐up, respectively; P=0.001). Whisker stimulation at the 3‐ and 24‐hour follow‐up led to reduced neurovascular coupling responses in the sensory cortex corresponding to the peri‐ischemic region compared with that observed at baseline. Conclusions Arterial occlusion led to contraction of capillary pericytes and capillary flow stalling in the peri‐ischemic cortex. Capillary dysfunction was associated with neurovascular uncoupling. Neurovascular coupling impairment associated with capillary dysfunction may be a mechanism that contributes to futile recanalization. Hence, the results from this study suggest a novel treatment target to improve neurological outcome after stroke.
Efficacy and safety of immune checkpoint inhibitors combined with anti-VEGF therapy in the treatment of unresectable or advanced liver cancer: a systematic review

Abstract Objective This study aimed to evaluate the clinical effects and safety of immune checkpoint inhibitors (ICIs) combined with anti-VEGF therapy for the treatment of unresectable or advanced liver cancer. Method Related databases were searched from inception to December 2022 to identify randomized controlled studies and clinical trials that evaluated the combination of ICIs and anti-VEGF therapy for the treatment of unresectable liver cancer. The outcome index was extracted and analyzed by RevMan5.4. Results A total of 8 clinical trials were included. In terms of efficacy, the intervention group had longer OS and PFS for unresectable or advanced liver cancer than the control group. In terms of safety, (1) Adverse events of all grades showed that the combination treatment led to significantly higher risks of urinary system disorders, cardiovascular system disorder, blood system disorders and liver dysfunction than the control treatment. Compared with monotherapy, the combination treatment led to lower risks of gastrointestinal disorders. (2) Adverse events above grade 3 showed that, compared with the control treatment, the combination treatment led to significantly higher risks of urinary system disorders, blood systeam disorders, cardiovascular system disorders and liver dysfunction. Additionally, compared with monotherapy, the combination treatment led to significantly lower risks of gastrointestinal disorders. Conclusions ICIs combined with anti-VEGF therapy exerts significant clinical effects in patients with unresectable or advanced liver cancer, can prolong the survival of these patients and can improve their quality of life. However, clinical attention should be given to the occurrence of adverse reactions.
Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice

Many patients with diabetic eye disease respond inadequately to anti-VEGF therapies, implicating additional vasoactive mediators in its pathogenesis. We demonstrate that levels of angiogenic proteins regulated by HIF-1 and -2 remain elevated in the eyes of people with diabetes despite treatment with anti-VEGF therapy. Conversely, by inhibiting HIFs, we normalized the expression of multiple vasoactive mediators in mouse models of diabetic eye disease. Accumulation of HIFs and HIF-regulated vasoactive mediators in hyperglycemic animals was observed in the absence of tissue hypoxia, suggesting that targeting HIFs may be an effective early treatment for diabetic retinopathy. However, while the HIF inhibitor acriflavine prevented retinal vascular hyperpermeability in diabetic mice for several months following a single intraocular injection, accumulation of acriflavine in the retina resulted in retinal toxicity over time, raising concerns for its use in patients. Conversely, 32-134D, a recently developed HIF inhibitor structurally unrelated to acriflavine, was not toxic to the retina, yet effectively inhibited HIF accumulation and normalized HIF-regulated gene expression in mice and in human retinal organoids. Intraocular administration of 32-134D prevented retinal neovascularization and vascular hyperpermeability in mice. These results provide the foundation for clinical studies assessing 32-134D for the treatment of patients with diabetic eye disease.
Safety of Nurse-Managed Inhaled Nitric Oxide During Critical Care Interfacility Transport

Inhaled nitric oxide (iNO) is an advanced therapy typically managed by physicians and respiratory therapists in order to increase arterial oxygenation and decrease pulmonary arterial pressure. The Johns Hopkins Lifeline Critical Care Transportation Program (Lifeline) initiated a novel nurse-managed iNO protocol in order to optimize the oxygenation of critically ill patients during interfacility transport. This study was a retrospective chart review of adverse events associated with iNO initiation or continuation by Lifeline on patients transported from March 1, 2020, to August 1, 2022. Basic demographic data and adverse events were recorded. Recorded adverse events included hypotension defined as a mean arterial pressure (MAP) < 65 mm Hg, hypoxemia defined as a decrease of ≥ 10% arterial oxygenation saturation measured by pulse oximetry, new bradycardia or tachyarrhythmia, nitrogen dioxide (NO2) levels greater than 1.0 ppm, methemoglobinemia, and cardiac arrest. Fifteen patients were diagnosed with SARS-CoV-2 infection, of which one also had pulmonary emboli, 2 had bacterial pneumonia, 1 suffered cardiogenic shock from occlusive myocardial infarction and were on VA-ECMO, and 2 had significant thoracic trauma resulting in pulmonary contusions and hemopneumothorax. iNO was continued on 10 patients and initiated on 8 patients, 2 of whom were transitioned from inhaled epoprostenol. Hypotension occurred in 3 (16.7%) patients and one (5.56%) of the hypotensive patients subsequently went on to experience new atrial fibrillation with vasopressor titration. No patients developed worsening hypoxemia, elevated NO2 levels, methemoglobinemia, or suffered cardiac arrest. All 3 patients who experienced hypotension were already on vasopressor support and the hypotension resolved with medication titration. This study shows that iNO administration can be safely managed by appropriately trained nurses.
Leptin–VEGF crosstalk in excess body mass and related disorders: A systematic review

By 2030, it is expected that a billion people will have suffer from obesity. Adipose tissue synthesizes leptin, an adipokine that affects cardiovascular risk. Leptin intensifies the synthesis of vascular endothelial growth factor (VEGF). Our study reviews recent reports on leptin–VEGF crosstalk in obesity and related disorders. PubMed, Web of Science, Scopus, and Google Scholar were searched. One hundred and one articles involving human, animal, and in vitro research were included. In vitro studies show the crucial role of interaction between endothelial cells and adipocytes and hypoxia as a factor that intensifies leptin's effects on VEGF. Leptin–VEGF crosstalk promotes the progression of cancer. The animal research reveal that a high‐fat diet enhances leptin and VEGF crosstalk. Genetic and epigenetic mechanisms and procreator‐offspring programming may be involved in leptin–VEGF crosstalk. Some female‐specific characteristics of leptin–VEGF relation in obesity were observed. The human studies have shown that increased leptin and VEGF synthesis and leptin–VEGF crosstalk are factors linking obesity with elevated cardiovascular risk. The studies of the last 10 years documented a range of significant aspects of leptin–VEGF crosstalk specific for obesity and related disorders, shedding new light on the link between obesity and increased cardiovascular risk.
LISREL 8.54: A PROGRAM FOR STRUCTURAL EQUATION MODELLING WITH LATENT VARIABLES

LISREL 8.54 is a computer program originally designed for estimation of a general structural equation model developed by Karl Jöreskog in the early 1970s (Jöreskog, 1973). Its current version, LISREL 8.54, is an advanced statistical program for multivariate analysis of linear systems with latent or unobserved variables, econometric structural equation systems, and a variety of factor analytic methods and covariance structure models. Recent developments also include powerful procedures for analysis with non-metric variables including latent variable models with ordinal indicators. The core code of the program is written in FORTRAN, but over the last decade its current vendor, Scientific Software International Inc. (SSI), developed an impressive interactive visual interface in C/C C C that made LISREL one of the most user-friendly multivariate analysis packages available. While preserving its raw power and flexibility, this multi-language architecture, however, contributed to instability problems associated with the 8.50/8.51 versions. Several subsequent upgrades have resulted in the 8.54 release that now more closely resembles the power and reliability of the earlier versions of this program. The LISREL 8.54 program (LISWIN32.EXE) is a 32-bit Windows application which interfaces with several modules, the main two of which are LISREL (LISREL85.EXE) and PRELIS (PRELIS25.EXE). 1 PRELIS was developed later than LISREL with the main purpose of providing a pre-processor and data transformation front-end to LISREL.
Therapeutic Equivalence of Biosimilar and Reference Biologic Drugs in Rheumatoid Arthritis

Key Points Question Are biosimilars of adalimumab, etanercept, and infliximab associated with equivalent treatment compared with their reference biologic drugs for the management of rheumatoid arthritis? Findings In this systematic review and meta-analysis of 25 randomized clinical trials that included data on 10 642 patients with rheumatoid arthritis, patients using biosimilars had equivalent clinical responses and functional capacity compared with patients using reference biologic drugs. Meaning These findings suggest that biosimilars may yield therapeutically equivalent outcomes compared with reference biologic drugs for the management of rheumatoid arthritis.
Inner Ear Malformations in Cochlear Implantation Candidates at Mother and Child Hospital of Bingerville (Côte d’Ivoire)

Abstract Objective The aim of this study was to determine the prevalence and types of inner ear and/or cochlear nerve anomalies in children who are candidates for cochlear implantation. Methods This was a descriptive cross-sectional study with a r etrospective review of medical and imaging records performed in a tertiary care children's hospital. All cochlear implants candidates under 15 years old with imaging assessment between January 2019 and December 2021 were concerned. The studied parameters were reason for consultation, risks factors, inner ear malformations (IEMs) classified and stratified by sensorineural hearing loss (SNHL) degree, gender, and age at diagnosis. Results In total, 81 children (162 ears) were included in the study. Abnormalities of the inner ear were found in nine children representing a prevalence of 11.1%. These children were aged between 2 and 14 years. The average age at diagnosis of SNHL was 3.5 years. Seven children had bilateral anomalies and two unilateral anomalies, that is, 16 ears presenting 40 malformations. These included 1 complete labyrinthine aplasia (2.5%), 12 cochlear malformations (30%), 1 common cavity (2.5%), 17 vestibular/squamous cell carcinoma (SCC) malformations (42.5%), and 5 internal auditory canal malformations (12.5%). Three ear out of 16 with abnormalities demonstrated a deficient cochlear nerve. There was an association between IEMs and profound deafness, and age at diagnosis of SNHL less than 2 years. Conclusion This study shows that 11.1% of children with profound deafness have IEMs. SCC malformations and cochlear hypoplasia were the most common. A precise description of these malformations during the imaging assessment is particularly useful for cochlear implantation to better plan this surgery.
Adressatengerechte Mobilitäts- und Teilhabeförderung im Pflegeheim

Zusammenfassung Hintergrund Bewohner*innen von Pflegeheimen erleben häufig Einschränkungen ihrer Mobilität und Teilhabe durch körperliche und/oder kognitive Veränderungen sowie durch Kontextfaktoren des Settings Pflegeheim. Da Mobilität und Teilhabe Gradmesser für Lebensqualität und Selbstbestimmung sind, sollte dem Mobilitätserhalt von Pflegeheimbewohner*innen eine hohe Aufmerksamkeit zukommen. Spezielle Bewegungsprogramme können auch bei älteren Menschen den Gesundheitszustand und die Leistungsfähigkeit positiv beeinflussen und das Sturzrisiko senken. Um Mobilität durch Aktivierungs- und Bewegungsangebote effektiv zu fördern, müssen diese auf individuelle Voraussetzungen und Bedürfnisse der Bewohner*innen abzielen. Deren Wünsche und Bedürfnisse hinsichtlich ihrer Mobilität sind bisher aber kaum bekannt. Ziel Untersuchung der subjektiven Perspektiven von Pflegeheimbewohner*innen hinsichtlich Mobilität und Teilhabe. Zudem wurde analysiert, inwieweit die individuelle Einschätzung ihrer Mobilität mit der Fremdeinschätzung von Pflegenden und ihrem tatsächlichen Mobilitätsstatus übereinstimmt. Methode Es wurden 10 Interviews mit Pflegeheimbewohner*innen durchgeführt und anhand der inhaltlich strukturierenden Inhaltsanalyse nach Kuckartz ausgewertet. Das Mobilitätsassessment für den Vergleich der Selbst- und Fremdeinschätzung des Mobilitätsstatus der Bewohner*innen erfolgte mit dem Erfassungsbogen „Mobilität“ (EBoMo). Ergebnisse Die Wünsche und Bedürfnisse der Bewohner*innen zu Mobilität und Teilhabe sind individuell sehr unterschiedlich, werden aber gegenüber Pflegeheimmitarbeitenden selten geäußert. Die Mehrzahl der Befragten wünscht sich eine Person mit gleichen Interessen für Gespräche. Zudem wurde deutlich, dass die Tagesgestaltung vom Ausmaß der körperlichen Mobilität abhängt. Der aktuelle Mobilitätsstatus wurde unterschiedlich eingeschätzt. Es dominierte eine Unterschätzung der Bewegungsfähigkeiten sowohl durch die befragten Bewohner*innen als auch durch die Pflegenden im Vergleich zur gemessenen Mobilität. Schlussfolgerung Um Pflegeheimbewohner*innen ein größeres Maß an Teilhabe zu ermöglichen und sie körperlich und geistig zu fördern, benötigt es ein Bewusstsein für deren Bedürfnisse und Sichtweisen. Der regelmäßigen Erfassung vorhandener Fähigkeiten und Wünsche von Bewohner*innen sollte daher ein höherer Stellenwert als bisher zukommen, um eine adressatengerechte Bewegungs- und Teilhabeförderung im Alltag zu ermöglichen.
Towards detecting device fingerprinting on iOS with API function hooking

Device fingerprinting is a technique that got popular at the end of the 90s by websites, to identify and track users. One of the biggest drivers behind such practices are advertising companies to identify users interests to personalize ads. From a user’s perspective, this, of course, raises privacy concerns. While device fingerprinting and its detection has been extensively studied in the context of web browsing, little research has been conducted on device fingerprinting in mobile apps and especially iOS apps. In this paper, we capture the current state of device fingerprinting in iOS apps, and explore possible approaches for fingerprinting detection on mobile devices using static and dynamic app analysis techniques. Finally, we present a first heuristic approach for automatic behavior-based fingerprinting detection on iOS only using spatial and temporal context of relevant API-calls.
Information visualisation for industrial process monitoring

In the context of process monitoring and predictive maintenance, an adapted visualisation of sensor data is essential in order to help the domain experts to make the right maintenance decision. The large volume and diversity of data leads us to aggregate the data to obtain semantically rich information useful to the domain expert. We study the case of industrial machinery equipped with several sensors producing time series, and we consider that this machinery has different operating states in its operation. We propose a method to identify an optimal representation of the data in 2 dimensions, understandable by the domain expert. This representation allows to easily identify the operating modes of the equipment and the possible deviation from a "normal" behavior. We use co-occurrence matrices to synthesise the time series data, and the features of interest and discretization are selected using two proposed criteria to measure the separation of working modes.
Effect of Power Conversion Efficiency of the RF Energy Harvester on the Security and Data Rate of the Self-Sustainable IoT Devices

This paper presents a study on the impact of the power conversion efficiency (PCE) of RF energy harvesters on the performance of wireless Internet-of-Things (IoT) devices including the sampling rate and data security. An RF energy harvester to harvest energy from the career frequency of 2.64 GHz is designed and prototyped for measurements. A microcontroller unit (MCU) adopts Tiny Encryption Algorithm (TEA) with a 128-bit key for data encryption. Measurement results indicate that as the amount of energy harvested increases, the maximum sampling rate and the security of the data can also increase. It implies the power conversion efficiency (PCE) impacts on both the data rate and data security of self-powered wireless IoT devices.
Seamless Parametrization with Cone and Partial Loop Control

We present a method for constructing seamless parametrization for surfaces of any genus that can handle any feasible cone configuration with any type of cones. The mapping is guaranteed to be locally injective, which is due to careful construction of a simple domain boundary polygon. The polygon’s complexity depends on the cones in the field, and it is independent of mesh geometry. The result is a small polygon that can be optimized prior to the interior mapping, which contributes to the robustness of the pipeline. For a surface of genus >0, non-contractible loops play an important role, and their holonomies significantly affect mapping quality. We enable holonomy prescription, where local injectivity is guaranteed. Our prescription, however, is limited and cannot handle all feasible holonomies due to monotonicity constraints that keep our polygon simple. Yet this work is an important step toward fully solving the holonomy prescription problem.
An iterative labeling method for annotating marine life imagery

This paper presents a labeling methodology for marine life data using a weakly supervised learning framework. The methodology iteratively trains a deep learning model using non-expert labels obtained from crowdsourcing. This approach enables us to converge on a labeled image dataset through multiple training and production loops that leverage crowdsourcing interfaces. We present our algorithm and its results on two separate sets of image data collected using the Seabed autonomous underwater vehicle. The first dataset consists of 10,505 images that were point annotated by NOAA biologists. This dataset allows us to validate the accuracy of our labeling process. We also apply our algorithm and methodology to a second dataset consisting of 3,968 completely unlabeled images. These image categories are challenging to label, such as sponges. Qualitatively, our results indicate that training with a tiny subset and iterating on those results allows us to converge to a large, highly annotated dataset with a small number of iterations. To demonstrate the effectiveness of our methodology quantitatively, we tabulate the mean average precision (mAP) of the model as the number of iterations increases.