Miracle-dz/UniFAR-FTUs huggingface dataset:
Association between mental health symptoms and behavioral performance in younger vs. older online workers

Background The COVID-19 pandemic has been associated with increased rates of mental health problems, particularly in younger people. Objective We quantified mental health of online workers before and during the COVID-19 pandemic, and cognition during the early stages of the pandemic in 2020. A pre-registered data analysis plan was completed, testing the following three hypotheses: reward-related behaviors will remain intact as age increases; cognitive performance will decline with age; mood symptoms will worsen during the pandemic compared to before. We also conducted exploratory analyses including Bayesian computational modeling of latent cognitive parameters. Methods Self-report depression (Patient Health Questionnaire 8) and anxiety (General Anxiety Disorder 7) prevalence were compared from two samples of Amazon Mechanical Turk (MTurk) workers ages 18–76: pre-COVID 2018 (N = 799) and peri-COVID 2020 (N = 233). The peri-COVID sample also completed a browser-based neurocognitive test battery. Results We found support for two out of three pre-registered hypotheses. Notably our hypothesis that mental health symptoms would increase in the peri-COVID sample compared to pre-COVID sample was not supported: both groups reported high mental health burden, especially younger online workers. Higher mental health symptoms were associated with negative impacts on cognitive performance (speed/accuracy tradeoffs) in the peri-COVID sample. We found support for two hypotheses: reaction time slows down with age in two of three attention tasks tested, whereas reward function and accuracy appear to be preserved with age. Conclusion This study identified high mental health burden, particularly in younger online workers, and associated negative impacts on cognitive function.
Chronic environmental circadian disruption increases atherosclerosis and dyslipidemia in female, but not male, ApolipoproteinE-deficient mice

Shift work chronically disrupts circadian rhythms and increases the risk of developing cardiovascular disease. However, the mechanisms linking shift work and cardiovascular disease are largely unknown. The goal of this study was to investigate the effects of chronically shifting the light-dark (LD) cycle, which models the disordered exposure to light that may occur during shift work, on atherosclerosis. Atherosclerosis is the progressive accumulation of lipid-filled lesions within the artery wall and is the leading cause of cardiovascular disease. We studied ApolipoproteinE-deficient (ApoE −/− ) mice that are a well-established model of atherosclerosis. Male and female ApoE −/− mice were housed in control 12L:12D or chronic LD shift conditions for 12 weeks and fed low-fat diet. In the chronic LD shift condition, the light-dark cycle was advanced by 6 h every week. We found that chronic LD shifts exacerbated atherosclerosis in female, but not male, ApoE −/− mice. In females, chronic LD shifts increased total serum cholesterol concentrations with increased atherogenic VLDL/LDL particles. Chronic LD shifts did not affect food intake, activity, or body weight in male or female ApoE −/− mice. We also examined eating behavior in female ApoE −/− mice since aberrant meal timing has been linked to atherosclerosis. The phases of eating behavior rhythms, like locomotor activity rhythms, gradually shifted to the new LD cycle each week in the chronic LD shift group, but there was no effect of the LD shift on the amplitudes of the eating rhythms. Moreover, the duration of fasting intervals was not different in control 12L:12D compared to chronic LD shift conditions. Together these data demonstrate that female ApoE −/− mice have increased atherosclerosis when exposed to chronic LD shifts due to increased VLDL/LDL cholesterol, independent of changes in energy balance or feeding-fasting cycles.
Status of animal health biosecurity measures of dairy farms in urban and peri-urban areas of central Ethiopia

Ethiopian dairy farming has many constraints including disease and lack of appropriate biosecurity measures. With this into consideration, a cross-sectional survey was carried out from November 2021 to April 2022 to determine the animal health biosecurity status of dairy farms and investigate the sociodemographic characteristics of livestock keepers on dairy farm management. A face-to-face questionnaire survey using an online application was used to collect data. The interview involved a total of 380 dairy farms located in six towns in central Ethiopia. The results showed that out of the surveyed farms, 97.6% missed footbaths at their gate points, 87.4% lacked isolation areas for either sick or newly introduced cattle, and 83.4% did not check the health status or quarantine newly introduced cattle. Furthermore, written formal record-keepings on animal health was uncommon, except for a few farms (7.9%). However, nearly all of the respondents (97.9%) gave medical treatments for sick cattle, and 57.1% of them vaccinated their herds regularly during the past 12 months before the survey. Hygienic aspects of the farms showed that 77.4% of the dairy farms appeared to clean the barn on a daily basis. However, 53.2% of respondents did not utilize personal protective equipment while cleaning their farms. A quarter of the dairy farmer (25.8%) avoided mixing their cattle with other herds, and 32.9% of them have implemented isolation of sick animals. In general, the animal health biosecurity assessment of the farms showed that most of the dairy farms (79.5%) earned unacceptable biosecurity levels (score of ≤ 50%), whereas the remaining 20.5% of dairy farms had received a score of >50% (“acceptable level”). The gender of dairy farmers (χ2 value = 7.61; p = 0.006), education level (χ2 value = 12.04; p = 0.007), dairy farm ownership (χ2 value = 41.6; p < 0.001), training on dairy farm management (χ2 value = 37.1; p < 0.001), towns (χ2 value = 31.69; p < 0.001), farm size (χ2 value = 7.7; p = 0.006), and herd size (χ2 value = 28.2; p < 0.001) showed a significant statistical association with biosecurity status. Finally, the study revealed that the level of biosecurity adoption of dairy farms in central Ethiopia is mostly unsatisfactory and calls for designing and implementing intervention measures toward improved animal health in dairy farms and further public health.
Astrocyte development—More questions than answers

The past 15–20 years has seen a remarkable shift in our understanding of astrocyte contributions to central nervous system (CNS) function. Astrocytes have emerged from the shadows of neuroscience and are now recognized as key elements in a broad array of CNS functions. Astrocytes comprise a substantial fraction of cells in the human CNS. Nevertheless, fundamental questions surrounding their basic biology remain poorly understood. While recent studies have revealed a diversity of essential roles in CNS function, from synapse formation and function to blood brain barrier maintenance, fundamental mechanisms of astrocyte development, including their expansion, migration, and maturation, remain to be elucidated. The coincident development of astrocytes and synapses highlights the need to better understand astrocyte development and will facilitate novel strategies for addressing neurodevelopmental and neurological dysfunction. In this review, we provide an overview of the current understanding of astrocyte development, focusing primarily on mammalian astrocytes and highlight outstanding questions that remain to be addressed. We also include an overview of Drosophila glial development, emphasizing astrocyte-like glia given their close anatomical and functional association with synapses. Drosophila offer an array of sophisticated molecular genetic tools and they remain a powerful model for elucidating fundamental cellular and molecular mechanisms governing astrocyte development. Understanding the parallels and distinctions between astrocyte development in Drosophila and vertebrates will enable investigators to leverage the strengths of each model system to gain new insights into astrocyte function.
Genetics and breeding for resistance against four leaf spot diseases in wheat (Triticum aestivum L.)

In wheat, major yield losses are caused by a variety of diseases including rusts, spike diseases, leaf spot and root diseases. The genetics of resistance against all these diseases have been studied in great detail and utilized for breeding resistant cultivars. The resistance against leaf spot diseases caused by each individual necrotroph/hemi-biotroph involves a complex system involving resistance (R) genes, sensitivity (S) genes, small secreted protein (SSP) genes and quantitative resistance loci (QRLs). This review deals with resistance for the following four-leaf spot diseases: (i) Septoria nodorum blotch (SNB) caused by Parastagonospora nodorum; (ii) Tan spot (TS) caused by Pyrenophora tritici-repentis; (iii) Spot blotch (SB) caused by Bipolaris sorokiniana and (iv) Septoria tritici blotch (STB) caused by Zymoseptoria tritici.
How and why humans trust: A meta-analysis and elaborated model

Trust exerts an impact on essentially all forms of social relationships. It affects individuals in deciding whether and how they will or will not interact with other people. Equally, trust also influences the stance of entire nations in their mutual dealings. In consequence, understanding the factors that influence the decision to trust, or not to trust, is crucial to the full spectrum of social dealings. Here, we report the most comprehensive extant meta-analysis of experimental findings relating to such human-to-human trust. Our analysis provides a quantitative evaluation of the factors that influence interpersonal trust, the initial propensity to trust, as well as an assessment of the general trusting of others. Over 2,000 relevant studies were initially identified for potential inclusion in the meta-analysis. Of these, (n = 338) passed all screening criteria and provided therefrom a total of (n = 2,185) effect sizes for analysis. The identified dependent variables were trustworthiness, propensity to trust, general trust, and the trust that supervisors and subordinates express in each other. Correlational results demonstrated that a large range of trustor, trustee, and shared, contextual factors impact each of trustworthiness, the propensity to trust, and trust within working relationships. The emphasis in the present work on contextual factors being one of several trust dimensions herein originated. Experimental results established that the reputation of the trustee and the shared closeness of trustor and trustee were the most predictive factors of trustworthiness outcome. From these collective findings, we propose an elaborated, overarching descriptive theory of trust in which special note is taken of the theory’s application to the growing human need to trust in non-human entities. The latter include diverse forms of automation, robots, artificially intelligent entities, as well as specific implementations such as driverless vehicles to name but a few. Future directions as to the momentary dynamics of trust development, its sustenance and its dissipation are also evaluated.
The impact of chronic rhinosinusitis on COVID-19 risk and outcomes: A systematic review and meta-analysis

Background The impact of chronic rhinosinusitis (CRS) and subsequent steroid therapy on acquiring COVID-19 and severe outcomes remains controversial. Therefore, we conducted this systematic review and meta-analysis to provide cumulative evidence regarding the risk of COVID-19 and the impact of steroid therapy, length of hospital stay, mechanical ventilation, and mortality among CRC patients. Methods We conducted a comprehensive electronic search strategy using the relevant keywords. The outcomes and risk factors of COVID-19 in CRS patients was estimated and compared to a healthy control group when applicable. Results A total of seven studies were included, with an estimated prevalence of 6.5% (95% confidence interval (CI): 2.5-15.7) for COVID-19 in the CRS group. COVID-19 prevalence did not differ between CRS and controls (odds ratio (OR): 0.92; 95%CI: 0.84-1.01; p = 0.08). Moreover, using steroid/immunosuppressive therapy did not significantly increase the risk of acquiring COVID-19 in CRS patients compared to the control group (OR: 3.31; 95%CI: 0.72-15.26; p = 0.12). Length of hospital stay, mechanical ventilation, and mortality rates were comparable between the two groups. Furthermore, we found that male sex, cardiovascular morbidity, renal diseases, and hypertension were inversely associated with COVID-19 infection (p < 0.01). Conclusion CRS had a neutral effect on acquiring COVID-19 and developing severe outcomes. However, further studies are needed.
Dorsal root ganglion neurons recapitulate the traumatic axonal injury of CNS neurons in response to a rapid stretch in vitro

Introduction: In vitro models of traumatic brain injury (TBI) commonly use neurons isolated from the central nervous system. Limitations with primary cortical cultures, however, can pose challenges to replicating some aspects of neuronal injury associated with closed head TBI. The known mechanisms of axonal degeneration from mechanical injury in TBI are in many ways similar to degenerative disease, ischemia, and spinal cord injury. It is therefore possible that the mechanisms that result in axonal degeneration in isolated cortical axons after in vitro stretch injury are shared with injured axons from different neuronal types. Dorsal root ganglia neurons (DRGN) are another neuronal source that may overcome some current limitations including remaining healthy in culture for long periods of time, ability to be isolated from adult sources, and myelinated in vitro. Methods: The current study sought to characterize the differential responses between cortical and DRGN axons to mechanical stretch injury associated with TBI. Using an in vitro model of traumatic axonal stretch injury, cortical and DRGN neurons were injured at a moderate (40% strain) and severe stretch (60% strain) and acute alterations in axonal morphology and calcium homeostasis were measured. Results: DRGN and cortical axons immediately form undulations in response to severe injury, experience similar elongation and recovery within 20 min after the initial injury, and had a similar pattern of degeneration over the first 24 h after injury. Additionally, both types of axons experienced comparable degrees of calcium influx after both moderate and severe injury that was prevented through pre-treatment with tetrodotoxin in cortical neurons and lidocaine in DRGNs. Similar to cortical axons, stretch injury also causes calcium activated proteolysis of sodium channel in DRGN axons that is prevented by treatment with lidocaine or protease inhibitors. Discussion: These findings suggest that DRGN axons share the early response of cortical neurons to a rapid stretch injury and the associated secondary injury mechanisms. The utility of a DRGN in vitro TBI model may allow future studies to explore TBI injury progression in myelinated and adult neurons.
NAC103 mutation alleviates DNA damage in an Arabidopsis thaliana mutant sensitive to excess boron

Excess boron (B) is toxic to plants and thereby causes DNA damage and cell death in root meristems. However, the underlying mechanisms which link boron and DNA damage remain unclear. It has been reported that the rpt5a-6 mutant of the 26S proteasome is sensitive to excess boron, resulting in more frequent cell death in root meristem and reduced root elongation. In this study, we showed that a reduction in root growth in the rpt5a mutant in the presence of high boron levels is repressed by a mutation in NAC domain containing transcription factor NAC103, a substrate of the proteasome, which functions in the unfolded protein response pathway. The mutation in NAC103 alleviated excess-B-induced DNA damage and cell death in root meristems of the rpt5a mutant. Superoxide ( O 2 − ) staining with nitroblue tetrazolium revealed that boron stress causes O 2 − accumulation in root tips, which was higher in the rpt5a-6 mutant, whereas the accumulation was lower in the rpt5a-6 nac103-3 double mutant. Our work demonstrates the overall involvement of NAC103 in maintaining healthy root meristem under excess boron conditions in the absence of RPT5A proteasome subunit.
Trapped field analysis in an HTS bulk with a crack using 3D finite element method

The trapped field variation of a high temperature superconducting (HTS) bulk before and after a crack happens, which was impossible to simulate using 2D analysis method, was calculated in this paper. 3D finite element method (FEM) and iteration method were used to find screening current distribution inside an HTS bulk. In 3D analysis of an HTS bulk with a crack, calculated current distribution inside an HTS bulk should obey the equation of current continuity. For this purpose, /spl nabla//spl phi/ variable was set to satisfy the equation of current continuity, which was impossible to be considered directly by the FEM governing equation using critical state model. Also, boundary condition at the surface of an HTS bulk was applied to consider the equation of current continuity. Simulation results were compared with experimental ones to verify the validity of the suggested simulation method.
Analysis of cell-free DNA concentration, fragmentation patterns and TP53 gene expression in mammary tumor-bearing dogs: A pilot study

Introduction Liquid biopsy based on the analysis of circulating cell-free DNA (cfDNA), as well as on detection of point mutations by digital droplet PCR (ddPCR), has revolutionized the research in oncology. In recent years, this technique has been pioneering in veterinary medicine since it is a minimally invasive approach with very promising results for characterization of tumors. Methods The aim of this study was, firstly, to analyze the concentration and the fragmentation pattern of cfDNA of dogs with mammary tumors (n = 36) and healthy dogs (n = 5) and its correlation with clinicopathological data. Secondly, analysis of TP53 gene expression and the point mutation in the codon 245 were performed in cfDNA and in tumor tissues to assess their potential as plasma biomarkers. Results and discussion Our results highlighted that those dogs with worse clinicopathological characteristics (simple or undifferentiated carcinomas, higher histological grade and presence of peritumoral inflammation) shown higher cfDNA concentration and higher concentrations of short-fragments (<190 bp) than healthy dogs. In addition, although no detection of the point mutation in codon 245 of TP53 gene could be detected neither in plasma nor tumor tissue, an increased TP53 expression was detected in animals with tumors bearing malignant characteristics. Finally, a high concordance with TP53 gene expression in plasma and tumor tissue and cfDNA concentration was also found. The results derived from this work confirm the valuable potential of cfDNA and its fragments, as well as the analysis of TP53 expression in plasma as useful liquid biomarkers for clinical application in veterinary oncology.
How Mindfulness Strategies Can Support Social and Emotional Learning Skill Development for Elementary Grade Students With Emotional and Behavioral Disorders

The best social and emotional learning (SEL) curriculum can be difficult to implement when students with or at risk for emotional and behavioral disorders (EBD) are unregulated and unprepared to engage in instruction. Daily mindfulness practices can help students with and at risk for EBD regulate their emotions and behaviors and be prepared for instruction. In this article, we provide examples and models of how informal mindfulness strategies can be incorporated into the elementary classroom to support student SEL growth. We also address how SEL instruction can be intensified using explicit mindfulness intervention programs to help meet the needs of students with EBD.
On the origin of filamentary structure in sunspot penumbrae: linear instabilities

The fine structure present in sunspot penumbrae first appears when filamentary convection sets in at the outer edge of large pores, coinciding with an increase in magnetic field inclination to the vertical. The formation of this filamentary structure is investigated in a highly idealized Boussinesq model. A two-dimensional equilibrium is constructed with the magnetic field at the bottom of the layer concentrated towards one side of the box, but fanning out towards the top of the layer, mimicking a sunspot. This two-dimensional steady state is then perturbed in the third direction, to seek filamentary instabilities leading to a filamentary structure. The two-dimensional model is found to be highly unstable for a range of transverse wavenumbers. The form of the instability is such that an alternating pattern of bright and dark filaments develops at the upper surface. This is the first numerical evidence of filamentary instabilities driven by external convection.
The Validity of a Self-reported Delinquency Scale

Self-reported delinquency scales have been widely adopted by researchers seeking to measure delinquency. Establishing the validity of these scales is critical because if valid measures are not created, findings about the correlates of delinquency will be of limited use in testing theory and formulating public policy. In this article, the authors use data from the first wave of the National Youth Survey to examine the measurement properties of a commonly used delinquency scale. The authors use the Rasch measurement model to test whether the scale meets the requirements of fundamental measurement and whether consistent measurement has occurred across subgroups including gender, age, race, and place of residence. Our results indicate that the original response category options are inadequate and differential item functioning exists across various subgroups. Methodological implications and directions for future research are identified.
The Densities and Growth Rates of Ice Crystals between

Abstract The mass of columnar ice crystals between −5C and −9C has been measured as a function of time. It is shown that the measured growth rates are not markedly different from the empirical formula proposed by Hindman and Johnson. However, during the first 3 min of growth the parametric form of the axial dimensions can be adequately described by a linear function of time rather than a power law. Over the same temperature range the bulk density/temperature curve deduced by Fukuta is valid for time periods at least as long as 3 min and for a wide variety of ice crystal concentrations.
Some properties of a two-body system under the influence of the Galactic tidal field

In this paper the effect of the Galactic tidal field on a Sun–comet pair will be considered when the comet is situated in the Oort cloud and planetary perturbations can be neglected. First, two averaged models were created, one of which can be solved analytically in terms of Jacobi elliptic functions. In the latter system, switching between libration and circulation of the argument of perihelion is prohibited. The non-averaged equations of motion are integrated numerically in order to determine the regions of the (e, i) phase space in which chaotic orbits can be found, and an effort is made to explain why the chaotic orbits manifest in these regions only. It is evident that for moderate values of semimajor axis, a∼50 000 au, chaotic orbits are found for (e<0.15, 40°≤i≤140°) as determined by integrating the evolution of the comet over a period of 104 orbits. These regions of chaos increase in size with increasing semimajor axis. The typical e-folding times for these orbits range from around 600 Myr to 1 Gyr and thus are of little practical interest, as the time-scales for chaos arising from passing stars are much shorter. As a result of Galactic rotation, the chaotic regions in (e, i) phase space are not symmetric for prograde and retrograde orbits.