Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of microglial exosomes in brain injury

Microglia are involved in immune responses to central nervous system (CNS) injury. Meanwhile, exosomes derived from microglia are important mediators of information and material exchange in brain, which play an important role in neuroprotective or damaging effects. Microglial exosomes contain a variety of molecular cargos, including microRNAs, soluble proteins, and lipids, which have regulatory effects on other types of cells and microenvironment in brain. In this review, we summarized microglial exosome characteristics, release patterns, pro-proliferative and pro-apoptotic effects on neurons and other glial cells, immunomodulatory effects, and regulation of the extracellular microenvironment. Understanding the relationship between microglia exosomes and brain injury can provide new targets for clinical treatment.
Modeling of Ballistic Electron Emission Microscopy on metal thin films

After the discovery of GMR by Fert and Gr\"unberg, electronics had a breakthrough with the birth of a new branch called spintronics. This discipline, while still young, exploits the spin of electrons. Most quantum devices exploiting this property of electrons consists of alternating magnetic and nonmagnetic thin layers on a semiconductor substrate. One of the best tools used for characterizing these structures is the so-called Ballistic Electron Emission Microscope (BEEM). Originally, it was dedicated to the imaging of buried objects and to the study of the potential barrier formed at the interface of a metal and a semiconductor. With the development of spintronics, the BEEM became an essential spectroscopy technique but still fundamentally misunderstood. The first realistic model, based on the non-equilibrium Keldysh formalism, was proposed to describe the transport of electrons during BEEM experiments. However, despite its success, its use was limited to the study of semi-infinite structures through a calculation method called decimation of Green functions. In this context, we have extended this model to the case of thin films and hetero-structures like spinvalves: starting from the same postulate that electrons follow the band structure of materials in which they propagate, we have established an iterative formula allowing calculation of the Green functions of the finite system by tight-binding method and encoded it in a F90 code. In parallel, we have developed a simpler method which allows to avoid passing through the non-equilibrium Keldysh formalism. Despite its simplicity, we have shown that this intuitive approach gives some physical interpretation qualitatively similar to the non-equilibrium approach. However, for a more detailed study, the use of "non-equilibrium approach" is inevitable, especially for the detection of thickness effects linked to layer interfaces.
Cartan Connections on Lie Groupoids and their Integrability

A multiplicatively closed, horizontal $n$-plane field $D$ on a Lie groupoid $G$ over $M$ generalizes to intransitive geometry the classical notion of a Cartan connection. The infinitesimalization of the connection $D$ is a Cartan connection $\nabla $ on the Lie algebroid of $G$, a notion already studied elsewhere by the author. It is shown that $\nabla $ may be regarded as infinitesimal parallel translation in the groupoid $G$ along $D$. From this follows a proof that $D$ defines a pseudoaction generating a pseudogroup of transformations on $M$ precisely when the curvature of $\nabla $ vanishes. A byproduct of this analysis is a detailed description of multiplication in the groupoid $J^1 G$ of one-jets of bisections of $G$.
Optimizing convex functions over nonconvex sets

In this paper we derive strong linear inequalities for sets of the form {(x,q) 2 R d × R : qQ(x), x 2 R d int(P)}, where Q(x) : R d ! R is a quadratic function, PR d and "int" denotes interior. Of particular but not exclusive interest is the case where P denotes a closed convex set. In this paper, we present several cases where it is possible to characterize the convex hull by efficiently separable linear inequalities.
Editorial: 2021 editors' pick: Computer science

COPYRIGHT © 2022 Lukowicz, Nijholt, Siddiqi, Pelillo, Laerhoven, Viganò and Zannone. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Editorial: 2021 editors’ pick: Computer science
Interfacial formation of intermetallic Ni-Al-Ti systems formed by induction heating

Intermetallic systems of Nickel (Ni), Aluminium (Al), and Titanium (Ti) are candidates for lightweight materials that offer high-temperature resistance. Combustion synthesis has been widely studied to produce intermetallic and coating deposition by exploiting the heat released by the combustion. An underlayer is often used to enhance the adhesion of the coating to the substrate. The interaction of the coating and the underlayer during heating is, therefore, crucial for achieving a good adhesion quality. This work aimed to investigate the microstructure and properties of the interfacial formation across the NiAl coatings and Ti underlayers formed by combustion synthesis. Induction heating was used to initiate the heating and reaction process with heating rates of 46.6, 57.0, and 85.5 K/s. The microstructure was characterized by Scanning Electron Microscopy (SEM) equipped with an Energy Dispersive Spectroscopy (EDS) detector, whereas the formed phases were identified using X-ray Diffraction (XRD) tests. The hardness distribution was measured by the Vickers microhardness test. The result shows that NiAl with Al-rich and Ni-rich were formed in the coating region. The average thickness of the coating increases by approximately 200, 300, and 400 µm with a heating rate of 46.6, 57.0, and 85.5 K/s, respectively. The different thicknesses of the coating can be attributed to the migration of Ni/Al from the coating to the underlayer zones. The microstructure observed in the underlayer confirms the formation of several intermetallic phases of Ni-Ti and Ti-Al systems. The infiltration of Ni and Al elements from Ni and Al to Ti sides was responsible for generating a reaction between Ni-Ai-Ti. The formation of Ti2Ni–Ti3Al phases in the underlayer increases with the heating rate. The hardness across the coating, interface, and underlayer increases with the heating rates. The heating rate of 46.6, 57.0, and 85.5 K/s results in the hardness of the interface by 669.1, 804.8, and 967.7 HV, whereas the underlayer increases by 680.1, 772.7, and 978.7 HV, respectively. The increased content of the Ni-Al-Ti system, which are AlNi2Ti and Ti2Ni–Ti3Al phases, was attributed to the increased hardness of the interface and underlayer. This work improves the understanding of second reactions across the interface while fabricating coatings that apply an underlayer.
Using a risk assessment framework to spatially and temporally spread the fishery catch limit for Antarctic krill in the west Antarctic Peninsula: A template for krill fisheries elsewhere

The west Antarctic Peninsula is an important breeding and foraging location for marine predators that consume Antarctic Krill (Euphasia superba). It is also an important focus for the commercial fishery for Antarctic krill, managed by the Commission for the Conservation of Antarctic Marine Living Resources (CCAMLR). Aiming to minimise ecosystem risks from fishing, whilst enabling a sustainable fishery, CCAMLR has recently endorsed a new management framework that incorporates information about krill biomass estimates, sustainable harvest rates and a risk assessment to spatially and temporally distribute catch limits. We have applied a risk assessment framework to the west Antarctic Peninsula region (Subarea 48.1), with the aim of identifying the most appropriate management units by which to spatially and temporally distribute the local krill catch limit. We use the best data currently available for implementing the approach, recognising the framework is flexible and can accommodate new data, when available, to improve future estimates of risk. We evaluated 36 catch distribution scenarios for managing the fishery and provide advice about the scale at which the krill fishery can be managed. We show that the spatial distribution with which the fishery currently operates presents some of the highest risks of all scenarios evaluated. We highlight important issues that should be resolved, including data gaps, uncertainty and incorporating ecosystem dynamics. We emphasize that for the risk assessment to provide robust estimates of risk, it is important that the management units are at a similar scale to ecosystem function. Managing the fishery at small scales has the lowest risk but may necessitate a high level of management interaction. Our results offer advice to CCAMLR about near-term management and this approach could provide a template for the rest of the southwest Atlantic (Area 48), or fisheries elsewhere. As each data layer influences the outcome of the risk assessment, we recommend that updated estimates of the distribution, abundance and consumption of krill, and estimates of available krill biomass will be key as CCAMLR moves forward to develop a longer-term management strategy.
The prognostic impact of preoperative body mass index changes for patients with esophageal squamous cell carcinoma who underwent esophagectomy: A large-scale long-term follow-up cohort study

Background This study aims to investigate the relationship between preoperative body mass index changes (ΔBMI) and prognosis in patients with esophageal squamous cell carcinoma who underwent esophagectomy. Methods We identified 1,883 patients with esophageal squamous cell carcinoma who underwent curative resection in our department between January 2005 and December 2013. Patients were grouped into a stable body mass index (ΔBMI = 0) group and a decreased body mass index (ΔBMI < 0) group. Risk factors for ΔBMI were assessed using logistic regression analysis. The impact of ΔBMI on survival was investigated using Kaplan–Meier curves and Cox regression. A nomogram for survival prediction was constructed and validated. Results The results showed that T stage (OR: 1.30, 95% CI: 1.16–1.45, P < 0.001) and N stage (OR: 1.24, 95% CI: 1.11–1.38, P < 0.001) were independent risk factors for ΔBMI. The ΔBMI < 0 group had worse overall survival than the stable body mass index group (HR: 1.25, 95% CI: 1.08–1.44, P = 0.002). When stratified by stage, ΔBMI had the greatest prognostic impact in stage I tumors (HR: 1.82, 95%: 1.05–3.15, P = 0.033). In addition, multiple comparisons showed that decreasing ΔBMI correlated with worse prognosis. The ΔBMI-based nomogram presented good predictive ability with a C-index of 0.705. Conclusion This study demonstrates that ΔBMI < 0 had an adverse impact on the long-term survival of patients with esophageal squamous cell carcinoma undergoing esophagectomy. These results may support further investigation of preoperative nutrition support.
CODING IN GRAPHS AND LINEAR ORDERINGS

Abstract There is a Turing computable embedding $\Phi $ of directed graphs $\mathcal {A}$ in undirected graphs (see [15]). Moreover, there is a fixed tuple of formulas that give a uniform effective interpretation; i.e., for all directed graphs $\mathcal {A}$ , these formulas interpret $\mathcal {A}$ in $\Phi (\mathcal {A})$ . It follows that $\mathcal {A}$ is Medvedev reducible to $\Phi (\mathcal {A})$ uniformly; i.e., $\mathcal {A}\leq _s\Phi (\mathcal {A})$ with a fixed Turing operator that serves for all $\mathcal {A}$ . We observe that there is a graph G that is not Medvedev reducible to any linear ordering. Hence, G is not effectively interpreted in any linear ordering. Similarly, there is a graph that is not interpreted in any linear ordering using computable $\Sigma _2$ formulas. Any graph can be interpreted in a linear ordering using computable $\Sigma _3$ formulas. Friedman and Stanley [4] gave a Turing computable embedding L of directed graphs in linear orderings. We show that there is no fixed tuple of $L_{\omega _1\omega }$ -formulas that, for all G, interpret the input graph G in the output linear ordering $L(G)$ . Harrison-Trainor and Montalbán [7] have also shown this, by a quite different proof.
Real-world intravascular ultrasound (IVUS) use in percutaneous intervention-naïve patients is determined predominantly by operator, patient, and lesion characteristics

Background Intravascular Ultrasound (IVUS) has been shown to improve clinical outcomes in patients undergoing percutaneous intervention (PCI) in numerous trials. However, it is still underutilized outside of trial settings, and most trials include a significant proportion of patients with prior PCI. The aim of this study is to look at real-world use and outcomes in PCI-naïve patients who undergo IVUS-guided intervention. Methods and results Prospectively collected data from 10,574 consecutive patients undergoing their index PCI was retrospectively analyzed. 455 (4.3%) patients underwent IVUS, with a median follow-up of 4.6 years. Patients undergoing IVUS had higher levels of comorbidities including diabetes (27.5% vs. 19.7%, p < 0.001), hypertension (58.0% vs. 47.9%, p < 0.001), hypercholesterolemia (51.6% vs. 39.2%, p < 0.001) and were generally older (65.9 ± 14.5 vs. 64.5 ± 13.4 years, p = 0.031) with higher mean baseline creatinine levels (95.4 ± 63.3 vs. 87.8 ± 46.1 μmol/L). The strongest predictor of IVUS use was the operating consultant graduating from medical school after the year 2000 [OR 14.5 (3.5–59.8), p < 0.001] and the presence of calcific lesions [OR 5.2 (3.4–8.0) p < 0.001]. There was no significant difference in MACE nor 1-year mortality between patients undergoing IVUS-guided or angiography-only PCI on unadjusted analysis [OR 1.04 (0.73—1.5), p = 0.81, OR 1.055 (0.65–1.71) p = 0.828] nor mortality throughout the study period (HR 0.93 (0.69—1.26), p = 0.638). This held true for stents longer than 28 mm. Propensity matched analysis of patients similarly showed no mortality difference between arms for all patients and those with longer stents (p = 0.564 and p = 0.919). Conclusion The strongest predictors of IVUS use in PCI-naïve patients are the operator’s year of graduation from medical school and proxy measures of calcific lesions. On both matched and adjusted analysis there was no evidence of improved mortality nor reduced MACE in this specific retrospective cohort, although this may well be explained by significant selection bias.
Relative Chow stability and optimal weights

For a polarized Kahler manifold $(X, L)$, we show the equivalence between relative balanced embeddings introduced by Mabuchi and $\sigma$-balanced embeddings introduced by Sano, answering a question of Hashimoto. We give a GIT characterization of the existence of a $\sigma$-balanced embedding, and relate the optimal weight $\sigma$ to the action of $\mathrm{Aut}_0(X,L)$ on the Chow line of $(X, L)$.
Editorial: Real-World evidence in onco-hematological patients

COPYRIGHT © 2022 Vener, Franchi and Trama. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. TYPE Editorial PUBLISHED 07 November 2022 DOI 10.3389/fonc.2022. 1060802
A 3D-CNN with temporal-attention block to predict the recurrence of atrial fibrillation based on body-surface potential mapping signals

Catheter ablation has become an important treatment for atrial fibrillation (AF), but its recurrence rate is still high. The aim of this study was to predict AF recurrence using a three-dimensional (3D) network model based on body-surface potential mapping signals (BSPMs). BSPMs were recorded with a 128-lead vest in 14 persistent AF patients before undergoing catheter ablation (Maze-IV). The torso geometry was acquired and meshed by point cloud technology, and the BSPM was interpolated into the torso geometry by the inverse distance weighted (IDW) method to generate the isopotential map. Experiments show that the isopotential map of BSPMs can reflect the propagation of the electrical wavefronts. The 3D isopotential sequence map was established by combining the spatial–temporal information of the isopotential map; a 3D convolutional neural network (3D-CNN) model with temporal attention was established to predict AF recurrence. Our study proposes a novel attention block that focuses the characteristics of atrial activations to improve sampling accuracy. In our experiment, accuracy (ACC) in the intra-patient evaluation for predicting the recurrence of AF was 99.38%. In the inter-patient evaluation, ACC of 3D-CNN was 81.48%, and the area under the curve (AUC) was 0.88. It can be concluded that the dynamic rendering of multiple isopotential maps can not only comprehensively display the conduction of cardiac electrical activity on the body surface but also successfully predict the recurrence of AF after CA by using 3D isopotential sequence maps.
Finding the seed of uniform attachment trees

A uniform attachment tree is a random tree that is generated dynamically. Starting from a fixed "seed" tree, vertices are added sequentially by attaching each vertex to an existing vertex chosen uniformly at random. Upon observing a large (unlabeled) tree, one wishes to find the initial seed. We investigate to what extent seed trees can be recovered, at least partially. We consider three types of seeds: a path, a star, and a random uniform attachment tree. We propose and analyze seed-finding algorithms for all three types of seed trees.
The impact of employees' pro-environmental behaviors on corporate green innovation performance: The mediating effect of green organizational identity

Employees' behaviors, as well as the employees' pro-environmental behaviors (PEB), affect the company in many dimensions. Although green innovation performance (GIP) has become an important measurement of a corporate's green development, research investigating PEB from the employees' perspective remains scarce, especially in emerging markets. Therefore, in this study, we developed an original framework to explore the effects of employees' PEB on corporate GIP and examined the underlying mechanism by conducting a survey in China. The results of the empirical analysis showed that employees' PEB increases corporate GIP by positively influencing green organizational identity (GOI). In addition, we also proved how leaders' PEB positively influences GIP, whereas innovation resistance (both technology resistance and resource resistance) has a negative effect on GIP. This study attempted to contribute to theoretical research and practical decision-making in the field of green organizational behavior.
The immunology of parasite infections: Grand challenges

COPYRIGHT © 2022 Donnelly. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. TYPE Specialty Grand Challenge PUBLISHED 08 November 2022 DOI 10.3389/fpara.2022. 1069205
The acute-to-chronic glycemic ratio correlates with the severity of illness at admission in patients with diabetes experiencing acute ischemic stroke

Acute hyperglycemia is a powerful indicator of the severity of acute ischemic stroke (AIS); however, the relationship between these two factors is not very clear in patients with diabetes. We aimed to retrospectively evaluate data from 335 consecutive patients who experienced AIS from November 2015 to November 2016 to investigate whether a comprehensive assessment of blood glucose levels is a more valuable indicator of the severity of AIS or the presence of acute hyperglycemia in patients with diabetes. We collected demographic data, clinical manifestation information, clinical scores, and laboratory data [including fasting blood glucose and glycated hemoglobin (HbA1c) levels]. We estimated prehospital mean blood glucose concentrations using the following formula [1.59 * HbA1c (%) – 2.59] to calculate the “Acute-to-Chronic Glycemic Ratio” (AC ratio). The AC ratio differed significantly among patients grouped according to the National Institutes of Health Stroke Scale/Score (NIHSS) at admission (admission NIHSS) (p = 0.006). Univariate regression analysis revealed a correlation between the AC ratio and admission NIHSS [standardized β-coefficient (Std. B) = 0.164, p = 0.004]. The adjusted linear regression analysis revealed a correlation between both HbA1c (Std. B = 0.368, p = 0.038) and the AC ratio (Std. B = 0.262, p = 0.022) and admission NIHSS. The AC ratio (Std. B = 0.161, p = 0.012) was related to admission NIHSS in the stepwise variable selection. For an admission NIHHS > 4, the AC ratio (Std. B = 0.186, p = 0.047) was related to admission NIHSS in the stepwise variable selection. The AC ratio (Std. B = 1.163, p = 0.006 and Std. B = 0.565, p = 0.021, respectively) were related to admission NIHSS in both large-artery atherosclerosis (LAA) and small-vessel occlusion (SVO) subgroups. Thus, the AC ratio is related to admission NIHSS in patients with diabetes who experienced AIS and may be a better indicator of severity than acute blood glucose levels.
Quantitative nonorientability of embedded cycles

We introduce an invariant linked to some foundational questions in geometric measure theory and provide bounds on this invariant by decomposing an arbitrary cycle into uniformly rectifiable pieces. Our invariant measures the difficulty of cutting a nonorientable closed manifold or mod-2 cycle in $\mathbb{R}^n$ into orientable pieces, and we use it to answer some simple but long-open questions on filling volumes and mod-$\nu$ currents.
Constructing solutions to two-way diffusion problems

A variety of boundary value problems in linear transport theory are expressed as a diffusion equation of the two-way, or forward–backward, type. In such problems boundary data are specified only on part of the boundary, which introduces several technical challenges. Existence and uniqueness theorems have been established in the literature under various assumptions; however, calculating solutions in practice has proven difficult. Here we present one possible means of practical calculation. By formulating the problem in terms of projection operators, we derive a formal sum for the solution whose terms are readily calculated. We demonstrate the validity of this approach for a variety of physical problems, with focus on a periodic problem from the field of active matter.
General construction of Reproducing Kernels on a quaternionic Hilbert space

A general theory of reproducing kernels and reproducing kernel Hilbert spaces on a right quaternionic Hilbert space is presented. Positive operator valued measures and their connection to a class of generalized quaternionic coherent states are examined. A Naimark type extension theorem associated with the positive operator valued measures is proved in a right quaternionic Hilbert space. As illustrative examples, real, complex and quaternionic reproducing kernels and reproducing kernel Hilbert spaces arising from Hermite and Laguerre polynomials are presented. In particular, in the Laguerre case, the Naimark type extension theorem on the associated quaternionic Hilbert space is indicated.