Miracle-dz/UniFAR-FTUs huggingface dataset:
Selective sterol accumulation in ABCG5/ABCG8-deﬁcient mice

The ATP binding cassette (ABC) transporters ABCG5 and ABCG8 limit intestinal absorption and promote biliary secretion of neutral sterols. Mutations in either gene cause sitosterolemia, a rare recessive disease in which plasma and tissue levels of several neutral sterols are increased to varying degrees. To determine why patients with sitosterolemia preferentially accumulate noncholesterol sterols, levels of cholesterol and the major plant sterols were compared in plasma, liver, bile, and brain of wild-type and ABCG5/ABCG8-deﬁcient ( G5G8 (cid:2) / (cid:2) ) mice. The total sterol content of liver and plasma was similar in G5G8 (cid:2) / (cid:2) mice and wild-type animals despite an (cid:2) 30-fold increase in noncholesterol sterol levels in the knockout animals. The relative enrichment of each sterol in the plasma and liver of G5G8 (cid:2) / (cid:2) mice (stigmasterol (cid:2) sitosterol (cid:3) cholestanol (cid:2) bassicas-terol (cid:2) campesterol (cid:2) cholesterol) reﬂected its relative enrichment in the bile of wild-type mice. These results indicate Selective sterol accumulation ABCG8-deﬁcient mice. 45:
Seismology Across the Solar System

Martin Knapmeyer1, Angela Marusiak2, Anna Horleston3, Ceri Nunn4 & Brigitte Knapmeyer-Endrun5 1DLR Institut für Planetenforschung, Berlin, Germany; martin.knapmeyer@dlr.de 2California Institute of Technology Jet Propulsion Laboratory, Pasadena, CA, USA; angela.marusiak@gmail.com 3School of Earth Sciences, University of Bristol, Bristol, UK; anna.horleston@bristol.ac. uk 4California Institute of Technology Jet Propulsion Laboratory, Pasadena, CA, USA; ceri.nunn@jpl.nasa. gov 5Bensberg Observatory, University of Cologne, Bergisch Gladbach, Germany; brigitte.knapmeyer-endrun@uni-koeln.de
Cyber Peace and Intrastate Armed Conflicts Toward Cyber Peacebuilding?

South Africa is a renowned case for its remarkable peacebuilding process that followed the transition from the apartheid era in the 1990s, particularly in terms of reconciliation, restorative justice, forgiveness, and healing from a violent past (Borris, 2002). However, the reconciliation process is ongoing, as seen in the first five days of September 2019 when some xenophobic, looting, and violent attacks emerged in Johannesburg. This time, the victims of those violent attacks were not black South Africans. Instead, the victims were Nigerians who lived and worked in South Africa (Holmes, 2019). This episode of violence could be impacted by different factors, including social media promotion. This example highlights a common feature of online communication in conflict-torn and postconflict societies in various parts of the world. The digital transformation has blurred the boundaries between cyberspace and “physical” space, creating a continuum between online and offline violence. As such, cyberspace has become a realm for political confrontation. Information and data can both be tools to empower dissidents while also being weapons for users, decision makers, governments, and armed groups (Berman, Felter & Shapiro, 2020; Duncombe, 2019). In this context, threats of violence are published on webpages and social media platforms to create and exacerbate a climate of fear. Violence targeted at specific minority groups reproduces offline practices of discrimination and hatred (Alexandra, 2018). Moreover, social media and messaging applications are used to mobilize populations generating large-scale collective actions that have created meaningful changes or call for actions worldwide, such as the cases of the Arab Spring (Salem, 2014), the Black Lives Matter movement in the United States (Zeitzoff, 2017), or the feminist movement in Argentina (Chenou and Másmela, 2019). These dynamics are particularly important in postconflict contexts where new opportunities for truth and reconciliation emerge while conflictual relationship might migrate online. 5
The Study on the Effectiveness of Preventive Methods for Online Piracy

As online use becomes commonplace in the digital environment, more and more people are indiscriminately copying, sharing, and reproducing online content. Thus, the government and institutions strengthen the level of punishment or take strong sanctions, but online piracy behavior is not reduced and becomes an ethically serious problem. Therefore, the purpose of this study is to empirically examine the effect of two common preventive methods, perceived morality and punishment, on self-control and piracy intention based on the deterrence theory. This study also attempts to investigate the mixed outcomes of gender differences to determine what preventive measures are gender-specific. The result of this study shows that the perceived morality directly effects on reducing online piracy intention while the perceived punishment effect on increasing self-control. The direct effect of punishment on reducing online piracy is moderated by online education. The gender differences vary the degree of morality by education and punishment. This study would provide both theoretical and practical implications emphasizing awareness and moral beliefs of online piracy and suggesting the awareness of gender differences in developing deterrence methods.
Knowledge-based clubhouse adoption intention in the post-covid-19 era in the hospitality industry

The COVID-19 pandemic has affected the digital transformation of the hospitality industry and triggered Clubhouse knowledge adoption behavior. Clubhouse engagement in the COVID-19 era has gradually changed the forms of communication. Hospitality industry owners can communicate about their interactions and trades through Clubhouse, and members can share their operating and management experiences. Therefore, hospitality industry owners can learn from and support each other. This study aims to bridge the gap between professional knowledge and management adoption in the community of hospitality industry owners. We treat members’ self-regulated and socially regulated learning styles as variables in our analysis of members’ behaviors after acquiring knowledge from the community. This study contributes to our understanding of knowledge-based digital transformation processes in the hospitality industry in the post-COVID-19 era. It has implications for both Clubhouse users and hosts. © 2021 International Consortium for Electronic Business. All rights reserved.
Click Happy?: An Analysis of the Use of An Electronic Voting System (EVS) in Large Group Lectures to Improve Interaction and Engagement

This paper outlines the findings from an action research study conducted at Salford Law School; reporting the responses of students to the inclusion of an electronic voting system (hereafter referred to as ‘clickers’) in large group Undergraduate Public Law lectures. The paper begins reflecting upon my current lecture practice in the context of existing literature and by reviewing feedback from previous cohorts of students. This reveals that the traditional, didactic lecture style, commonly employed by law lecturers in the UK has been criticized for fostering student passivity and resulting in surface learning (Ramsden, 1992). In contrast, studies carried out in pure science disciplines; medicine, engineering and mathematics (Hake, 1998; Crouch and Mazur, 2001) indicate positive results from use of clicker quizzes, in terms of increasing student interaction and engagement. Accordingly, I decided to incorporate clicker quizzes into lectures, and measure student responses to this change in teaching practice. The findings indicate that clicker usage increased student interaction and engagement. This study concludes that clickers should be used on an ongoing basis in Public law lectures, and also indicates positive support from students regarding the use clickers in other undergraduate law subjects. Furthermore, although the findings from this action research study are not generalisable, the responses suggest that clickers could be an effective teaching tool in large group sessions in other disciplines, since they replicate findings from previous studies in other disciplines.
ON THE THEORY OF LIGHT PRODUCTION AND LIGHT ABSORPTION

In a study published last year1 I showed that the Maxwell theory of [2] electricity in conjunction with the theory of electrons leads to results that contradict the evidence on black-body radiation. By a route described in that study, I was led to the view that light of frequency v can only be absorbed or emitted in quanta of energy [R/N)0v, where R denotes the absolute constant of the gas equation applied to one gram-molecule, N the number of actual molecules in one gram-molecule, 0 the exponential coefficient of Wien's (and Planck's) radiation formula, and v the frequency of the light in question. This relationship was developed for a range that corresponds to the [3] range of validity of Wien's radiation formula. At that time it seemed to me that in a certain respect Planck's theory of radiation2 constituted a counterpart to my work. New considerations, which are being reported in §1 of this paper, showed me, however, that the theore­ tical foundation on which Mr. Planck's radiation theory is based differs from the one that would emerge from Maxwell's theory and the theory of electrons, precisely because Planck's theory makes implicit use of the aforementioned hypothesis of light quanta. In §2 of this paper I shall make use of the hypothesis of light quanta to derive a relationship between the Volta effect and photoelectric diffusion.
A high step-up DC–DC soft-switched converter using coupled inductor and switched capacitor

ABSTRACT In this paper, a zero-voltage-switching (ZVS) high step-up three level coupled inductor-based boost converter is proposed. Three-level structure of the proposed converter causes significant reduction of the switches and diodes voltage stress. The leakage inductance that is caused by coupled inductor leads to voltage ringing, the use of the active-clamp circuit in this structure not only eliminates the voltage ringing but also makes all switches turn on and off under ZVS condition that results in improving the efficiency. All the switches in the proposed converter will operate with an appropriate duty cycle for high step-up applications. The proposed converter features, operating principles and analysis are discussed in the paper and to verify the validity of theoretical analysis, the experimental results of a 200-W laboratory prototype with a 4-V input and 400-V output are presented.
Electromagnetic formation flight for LEO satellites

Electromagnetic formation flight (EMFF) for satellites in LEO is discussed. EMFF is a technique to control the satellites’ relative position using electromagnetic force without any propellants. It is estimated that the superconductive magnets have capability to produce required magnetic force for formation keeping. The problem to use EMFF in LEO is the huge amount of disturbance torque, caused by enormous magnetic moment and earth magnetic field. Sinusoidal driving of the superconductive coil is proposed for this issue, and novel method is also proposed for magnetic force control using phase difference between the magnetic moments. Proposed methods are evaluated with experiments with actual superconductive coil, and hardware in the loop simulations is also carried out to demonstrate the relative position control capability of proposed system.
Estudo do ponto invariante com a temperatura (ZTC) em SOI-FInFETS tensionados e radiados.

This work was performed with the aim of the study of the invariant point with temperature (called ZTC – Zero temperature Coefficient) for transistors made with SOI FinFET structure in relation to the mechanical stress and irradiation effects, through of the use of experimental data and an analytical model. Were first analyzed the basics parameters as threshold voltage and transconductance, in which all the model is based and was verified the influence of the mechanical stress and irradiation effects on these parameters, for analyze the gate voltage’s behavior on ZTC point in n type devices. Were used devices with three different width fin dimensions, 20nm 120nm and 370nm and channel length of 150nm and in a comparative way with 900nm length devices, in four different waffles, with/without mechanical stress and/or with/without irradiation. The threshold voltage suffers big influence from stress, while the irradiation has less effect on the threshold voltage in the studied band, becoming to have more significance on the stressed devices with larger fin width. The transconductance also suffers more influence of the stress effect, being on this parameter the variation caused by irradiation effect smaller. However, these two parameters generate others two essentials parameters for the ZTC analysis, they are obtained through of the previous parameters variation by the temperature. The threshold voltage variation by the temperature and the tranconductance degradation by the temperature (or c factor: mobility degradation by the temperature), influence directly on the eventual variation of the ZTC point by the temperature. When these influences are small or act by the way to compensate mutually, result at ZTC values more constant with the temperature. The threshold voltage influence direct proportionality on the ZTC voltage’s value at amplitude, while the mobility (transconductance) degradation act more on ZTC stability with the temperature. Based in these same parameters and with necessaries adjusts on the model, were studied devices with the same physic characteristics, but of the p type, where the founded results had relation with the work characteristics of this other type, becoming clear the inversion of significance of the effects by the temperature variation. The simple and analytical model used for the ZTC study was validated for this technology, since it was found error values between experimental data and calculated data with a maximum of 13%, shown discrepant values only for some cases of larger fin widths, that shown to have a small conduction by the channel/buried oxide interface before of the first interface’s conduction, not previewed in the model.
DETERMINANTE INICIJALNOG KRVARENJA I RECIDIVA KRVARENJA DUODENALNIH

SUMMARY Acute bleeding of the upper gastrointestinal tract is an urgent condition with high morbidity, and a significant mortality despite ad- vanced diagnostics and therapy. The goal is to investigate the determinants of the severity of duodenal peptic ulcer bleeding. The research included 304 patients hospitalized for acute bleeding from the upper part of gastrointestinal tract in a five year period. They had been treated in the Clinical Hospital Center Bežanijska Kosa in Belgrade. The diagnosis was made via gastroduodenoscopy. Out of the 304 patients, 197 (65%) suffered from bleeding peptic ulcer. 144 (73,1%) patients suffered from bleeding duodenal ulcer, most frequently with bulbar localization 124/86 (12%); 78 (62,9%) with a duodenal bulb back wall lesion. 48 (35,1%) of the bleeding duodenal ulcers were in the Forrest Ib stage, in 68 (47,2%) patients the size of the ulcer lesion was between 1,1-2,0 cm. A statisti- cally positive correlation was determined between the duodenal ulcer lesions and the intensity of the bleeding (p<0,005). With 68/79/86,1% patients treated endoscopically, haemostasis was successful, whereas in 13/19,1%, rebleeding was localized in 11/84,6% in the duodenum bulb bask wall.
(2019). To Dialyse or not to Dialyse – Is that the Question? A Psychosocial Perspective on Dilemmas Concerning Dialysis for People with Dementia. Dementia , 18 (4), 1341-1353.

There is increasing recognition that the organisation of healthcare into specialist areas of practice can be counterproductive for older people with multiple morbidities and that dementia can raise particular challenges in healthcare. In the context of treatment for chronic kidney disease these challenges concern complex decisions about the suitability and efficacy of dialysis and other treatments. This article draws on a literature review to present a psycho-social perspective on these decisions. It considers the value of the concept of ‘dementia-friendliness’ for nephrology practice, and suggests how this could provide a valuable frame of reference for nephrology professionals to ensure they are best equipped to work with people living with dementia and their carers and to ensure that the individual patient is truly at the centre of their treatment regime.
Identification of the complement iC3b binding site in the .82 integrin CR3

The divalent cation-dependent interaction of the 132 Integrln CR3 (CDllb/CD18) with the major complement opsonic C3 fragment iC3b is an important component of the central role ofCR3 in inflammation and immune clearance. In this investigation we have identified the iC3b binding site in CR3. A recombinant fragent representing the CR3 A-do-main, a 200-amino acid region in the ectodomain of the CDlb subunit, bound to iC3b directly and in a divalent cation-dependent manner. The iC3b binding site was further localized to a short linear peptide that also bound iC3b directly and inhibited iC3b binding to the A-domain as well as to CR3 expressed by human neutrophils. These data establish a major recognition function for the integrin A-domain and have important implications for development of novel antlinflamma-tory therapeutics.
Interpretaciones del Coeficiente Alpha de Cronbach

Within the history of Classical Test Theory, coefficient alpha has had a large role; thus, several researchers have investigated it in order to better understand its behaviour. The present article discusses different ways in which this coefficient has been interpreted in psychometrical reliability theory, as well as several studies which provide some guidelines on its proper use. The limitations encountered on using alpha as a reliability estimator under different actual test circumstances are highlighted.
Pengembangan Website Jii - Analisa.Com Sebagai Alat Analisis Portofolio Optimum Metode Varian Kovarian Pada Pasar Modal Syariah Di Indonesia

Penelitian ini bertujuan mengembangkan website JII-Analisa.com sebagai alat analisis portofolio syariah optimum metode varian kovarian. Website JII-Analisa.com dikembangkan dengan menggunakan SDLC (Sysems Development Life Cycle) yang terdiri atas 5 (lima) langkah, yaitu perencanaan rencana strategis pengembangan website, penentuan ruang lingkup pengembangan, analisis kebutuhan yang diperlukan, membuat desain dan implementasi pembuatan website serta pengujian. Secara umum terdapat 2 (dua) langkah yang dapat dilakukan untuk melakukan analisis portofolio optimum menggunakan JII.Analisa.com, yaitu pemilihan saham pembentuk portofolio menggunakan menu Analisis Saham dan perhitungan portofolio optimum. Hasil implementasi website untuk periode data 01 Januari 2014 – 28 Februari 2015 diperoleh proporsi untuk masing – masing saham pembentuk portofolio optimum adalah KLBF.JK sebesar 35%, JSMR.JK 30%, SSMS.JK 17%, MPPA.JK 12%, PTPP.JK 5%, dan PWON.JK 0.2% dengan Return yang dihasilkan sebesar 0.21%, risiko sebesar 1.01% dan indeks sharpe 0.20655.
Bit Error Rate Analysis of Jamming for OFDM Systems

This work evaluates the BER performance of different jamming strategies including Barrage Noise Jamming (BNJ), Partial Band Jamming (PBJ) and Multi-tone Jamming (MTJ) in time-correlated Rayleigh fading channel with AWGN . In this paper, we use Binary Phase Shift Keying (BPSK) as our signal mapping method. Higher order modulation techniques can be used as well, but these two are sufficient for us to analyze the essence of the problem. The Cyclic Prefix is used as Guard Interval to eliminate ISI between the data blocks.
coldwater coral patches

Despite the importance for ecosystem functioning, little is known about flow patterns at the cold-water coral-patch scale (i.e., centimetre-meter). In-situ flow speed measurements using moorings or landers only provide general near reef flow patterns and experimental studies so far focussed on single coral branches for feeding and behavioural studies. We address this knowledge gap by means of a flume study. The effect of different coral patches (4, 10 and 25 cm height, respectively) created from dead coral branches on the ambient flow field and the refreshment rate of water within a patch was assessed, using three realistic current speeds (0.05, 0.15 and 0.3 m s -1 ). High bottom roughness in combination with strong currents increased current velocity and turbulence in the wake of all patches, even with very low relief. The formation of two dynamically different environments was observed. The framework-water interface was characterised by high turbulence and enhanced vertical turbulent transport of momentum, while in the wake reduced turbulence and vertical mixing activity was observed, characterised by near stagnant flows. Subsequently, water-refreshment rates within a patch drastically decreased at current speeds less than 0.2 m s -1 , while near to unobstructed stream conditions were observed at current speeds above 0.2 m s -1 . Combining flume observations with available in-situ data suggest that heterogeneity and patchiness of coldwater coral growth is likely induced by flow patterns at the coral patch scale, influencing the fate of particulate and dissolved matter as well as oxygen exchange rates in and around the reef.
AMALAN SISTEM PENYAMPAIAN PERKHIDMATAN DAN PRESTASI PIHAK BERKUASA TEMPATAN

Sistem penyampaian perkhidmatan yang cekap menjadi keutamaan pihak kerajaan amnya dan khususnya pihak berkuasa tempatan. Ini selaras dengan kehendak komuniti masyarakat telah menetapkan kecekapan sistem penyampaian sebagai keutamaan kepada agensi ini. Fungsi PBT dewasa ini semakin mencabar selari dengan perubahan persekitaran yang begitu pantas terutama sekali perubahan cita rasa pelanggan. Keadaan ini memerlukan PBT menyediakan perkhidmatan yang lebih berkualiti kepada pelanggan mereka. Kajian ini menyelidiki tahap amalan sistem penyampaian perkhidmatan PBT dan hubungannya dengan prestasi. Bagi tujuan tersebut sebanyak 429 borang soal selidik telah dihantar kepada jabatan dalam organisasi PBT yang terdiri dari Majlis Bandar raya dan Majlis Perbandaran dengan kadar pulangan soal selidik adalah 48%. Dengan menggunakan kaedah analisis faktor dan statistik deskriptif, hasil kajian menunjukkan tahap sistem penyampaian perkhidmatan di PBT boleh diukur dengan lima dimensi berikut – orientasi tolak tarik dalam operasi perkhidmatan, pembangunan dan reka bentuk perkhidmatan yang baru, pengkhususan sumber manusia dalam operasi perkhidmatan, pelbagai perkhidmatan ditawarkan dan jenis susun atur operasi perkhidmatan. Bagi setiap dimensi ketua jabatan PBT menyatakan bahawa jabatan mereka mengamalkan orientasi tolak dalam operasi perkhidmatan, tahap pengenalan perkhidmatan yang tinggi, tahap pengkhususan sumber manusia yang tinggi, pelbagai perkhidmatan yang meluas ditawarkan dan jenis susun atur operasi perkhidmatan yang tetap. Manakala kesemua dimensi ini mempunyai pengaruh yang signifikan kepada prestasi. Kata kunci : amalan operasi perkhidmatan, sistem penyampaian perkhidmatan, prestasi Abstract The efficiency of service delivery system is a priority of the government in general and in particular local authorities. This is in line with community needs that public delivery system has been set as priorities for this agency. Local Authority functions is increasingly challenged in line with environmental changes, especially changes in customer requirement. This situation requires local authorities to provide better quality services to their customers. This study investigates the level of service delivery system and its relation to the performance of local authorities.