Miracle-dz/UniFAR-FTUs huggingface dataset:
Quality, opportunity, and treatment of data of tuberculosis and human immunodeficiency virus co-infection

Background and Objectives: The identification, evaluation, and use of methodological resources for data quality analysis is important to support planning actions of public policies for the control of tuberculosis (TB) and the co-infection TB and human immunodeficiency virus (HIV). The objective was to analyze the quality and timeliness of notification of TB and TB-HIV co-infection cases from the Notifiable Diseases Information System (SINAN - Sistema de Informação de Agravos de Notificação) in Espírito Santo State, from 2016 to 2018. Methods: This is a cross-sectional study of the quality of SINAN data using the Centers for Disease Control and Prevention (CDC) guidelines to analyze the quality and timeliness of SINAN-TB notification, with emphasis on the description of TB-HIV co-infection in Espírito Santo State, from 2016 to 2018. It considered five methodological steps that included quality analysis, standardization of records, duplicity analysis, the completeness of data through linkage with the SINAN-HIV database and anonymization of data. It obtained ethical approval under the number 4022892 on 12/05/2020. Results: The study showed that 89% of mandatory variables and 91% of essential variables showed satisfactory completeness. In TB-HIV co-infection 73% of the variables were completed, but essential variables related to TB treatment follow-up showed unsatisfactory completeness. The timeliness of reporting was considered regular. Conclusion: Improvements in work processes and the development of a specific methodological process for data treatment are necessary to qualify the information available in SINAN-TB.
Digital Commons @ New Haven Digital Commons @ New Haven

Sustainable development initiatives address the issues related to economic growth and mobility, and environmental conservation. Sustainable transportation in the U.S. is an essential component of these initiatives. In this context, since the U.S. is a federally governed country, the needs for policy making can be different from one state to another, which requires state-by-state focus prior to sustainability assessment projects. This study aims to contribute to the scholarship by proposing a slack-based measurement data envelopment analysis (SBM-DEA) model with non-radial approach. This study assesses environmental efficiency of U.S states’ transportation sectors from 2004 to 2012. In addition to the environmental efficiency measurement, carbon efficiency, and potential carbon reduction were estimated for the states of the U.S. SBM-DEA provided more comprehensive analysis that combines economic and environmental indicators. This approach also captures the excess input and undesirable output (CO 2 ), and shortfall of desirable output. The findings of this study revealed that the states’ transportation sectors are environmentally inefficient showing that on average states had an environmental efficiency score below 0.64. Therefore, the states need to substantially reduce carbon emissions to improve environmental efficiency of transportation.
The role of oxidative stress in the development of alcoholic liver disease (cid:2)

Background: Alcohol is the most accepted addictive substance worldwide and its consumption is related to multiple health, economic, and social problems. The liver is the organ in charge of ethanol metabolism and it is susceptible to alcohol’s toxic effects. Objetivos: To provide a detailed review of the role of oxidative stress in alcoholic liver disease and the mechanisms of damage involved, along with current information on the hepatoprotective effectiveness of the molecules that have been studied. Materials and methods: A search of the PubMed database was conducted using the following
REVISTA DE CONTABILIDAD SPANISH ACCOUNTING REVIEW

This paper aims to analyze the online transparency of the top 100 Universities in the world and determine which factors inﬂuence the degree of online transparency achieved by these institutions. To this end, a global transparency index was developed comprising of four dimensions (“E-Information”, “E-Services”, “E-Participation” and “Navigability, Design and Accessibility”). From the analysis of the various dimensions, it is worth noting that universities are aware of the importance of having a web page with adequate “Navigability, Design and Accessibility”. In contrast, “E-information” is the least valued dimension due to universities focusing their attention on the disclosure of general information rather than on more speciﬁc issues. In addition, a multivariate regression equation was used to test the relationship between the online information disclosed and a particular set of factors. As main ﬁndings, younger universities of greater size and which are privately funded are the ones most interested in utilizing web pages.
The complex genetic architecture of recombination and structural variation in wheat uncovered using a large 8-founder MAGIC population

Background Identifying the genetic architecture of complex traits requires access to populations with sufficient genetic diversity and recombination. Multi-parent Advanced Generation InterCross (MAGIC) populations are a powerful resource due to their balanced population structure, allelic diversity and enhanced recombination. However, implementing a MAGIC population in complex polyploids such as wheat is not trivial, as wheat harbours many introgressions, inversions and other genetic factors that interfere with linkage mapping. Results By utilising a comprehensive crossing strategy, additional rounds of mixing and novel genotype calling approaches, we developed a bread wheat eight parent MAGIC population made up of more than 3000 fully genotyped recombinant inbred lines derived from 2151 distinct crosses, and achieved a dense genetic map covering the complete genome. Further rounds of inter-crossing led to increased recombination in inbred lines, as expected. The comprehensive and novel approaches taken in the development and analysis of this population provide a platform for genetic discovery in bread wheat. We identify previously unreported structural variation highlighted by segregation distortion, along with the identification of epistatic allelic interactions between specific founders. We demonstrate the ability to conduct high resolution QTL mapping using the number of recombination events as a trait, and identify several significant QTLs explaining greater than 50% of the variance. Conclusions We report on a novel and effective resource for genomic and trait exploration in hexaploid wheat, that can be used to detect small genetic effects and epistatic interactions due to the high level of recombination and large number of lines. The interactions and genetic effects identified provide a basis for ongoing research to understand the basis of allelic frequencies across the genome, particularly where economically important loci are involved.
Digital Commons @ University of South Florida Digital Commons @ University of South Florida

Middle cerebral artery occlusion in rodents remains a widely used model of ischemic stroke. Recently, we reported the occurrence of retinal ischemia in animals subjected to middle cerebral artery occlusion, owing in part to the circulatory juxtaposition of the ophthalmic artery to the middle cerebral artery. In this study, we examined the eye hemodynamics and visual deficits in middle cerebral artery occlusion-induced stroke rats. The brain and eye were evaluated by laser Doppler at baseline (prior to middle cerebral artery occlusion), during and after middle cerebral artery occlusion. Retinal function-relevant behavioral and histological outcomes were performed at 3 and 14 days post-middle cerebral artery occlusion. Laser Doppler revealed a typical reduction of at least 80% in the ipsilateral frontoparietal cortical area of the brain during middle cerebral artery occlusion compared to baseline, which returned to near-baseline levels during reperfusion. Retinal perfusion defects closely paralleled the timing of cerebral blood flow alterations in the acute stages of middle cerebral artery occlusion in adult rats, characterized by a significant blood flow defect in the ipsilateral eye with at least 90% reduction during middle cerebral artery occlusion compared to baseline, which was restored to near-baseline levels during reperfusion. Moreover, retinal ganglion cell density and optic nerve depth were significantly decreased in the ipsilateral eye. In addition, the stroke rats displayed eye closure. Behavioral performance in a light stimulus-mediated avoidance test was significantly impaired in middle cerebral artery occlusion rats compared to control animals. In view of visual deficits in stroke patients, closely monitoring of brain and retinal perfusion via laser Doppler measurements and examination of visual impairments may facilitate the diagnosis and the treatment of stroke, including retinal ischemia.
Miri Albahari Witness-Consciousness Its Definition, Appearance and Reality 1

: G.E. Moore alludes to a notion of consciousness that is diaphanous, elusive to attention, yet detectable. Such a notion, I suggest, approximates what Bina Gupta has called ‘witness-conscious-ness’ — in particular, the aspect of mode-neutral awareness with intrinsic phenomenal character. This paper offers a detailed definition and defence of the appearance and reality of witness-consciousness. While I claim that witness-consciousness captures the essence of subjectivity, and so must be accounted for in the ‘hard problem’ of consciousness, it is not to be confused with the more commonly defended notion of ‘for-me-ness’.
Pompe's disease: A report of ten cases

Pompe’s disease is a rare inherited metabolic disorder, which often leads to infantile death from severe cardiomyopathy. This report describes ten infants with clinical findings suggestive of Pompe’s disease confirmed by histological investigation. All the infants had presented with cardiopulmonary symptoms. Two dimensional and Doppler echocardiography revealed hypertrophic cardiomyopathy and six of them had left ventricular outflow tract obstruction. We emphasized the importance of echocardiography in the clinical diagnosis of this severe condition.
A comprehensive evaluation of enhanced temperature influence on gas and aerosol chemistry in the lamp-enclosed oxidation flow reactor (OFR) system

Oxidation flow reactors (OFRs) have been widely used to investigate the formation of secondary organic aerosol (SOA). However, the UV lamps that are commonly used to initiate photochemistry in OFRs can lead to increases in the reactor temperature with consequences that have not been assessed in detail. In this study, we systematically investigated the temperature distribution inside an Aerodyne Potential Aerosol Mass OFR and the associated impacts on flow and 35 chemistry arising from lamp heating. A lamp-induced temperature enhancement was observed, which was a function of lamp driving voltage, number of lamps, lamp types, OFR residence time, and positions inside OFR. Under common OFR operational conditions (e.g., < 5 days of equivalent atmospheric OH exposure under low-NOx conditions), the temperature enhancement was usually within 1-5 °C . Under extreme (but less commonly used) settings, the heating could reach 15 °C . The influence of the increased temperature over ambient conditions on the flow distribution, gas, and condensed phase 40 chemistry inside OFR was evaluated. We found that the increase in temperature changes the flow field, leading to a reduced tail on the residence time distribution and corresponding oxidant exposure due to faster recirculation. According to simulation results from a box model using radical chemistry, the variation of absolute oxidant concentration inside of OFR due to temperature increase was small (<5%). The temperature influences on existing and newly formed OA were also investigated, suggesting that the increase in temperature can impact the yield, size, and oxidation levels of representative 45
The Diabetic Foot – Pain – Depression Cycle A Multidisciplinary Cohort Study

Background: More than 86,000 Americans with type 2 diabetes mellitus (T2DM) undergo nontraumatic lower-extremity amputations annually. The opioid-prescribing practice of podi-atric surgeons remains understudied. We hypothesized that patients with T2DM who undergo any forefoot amputation while using antidepressant medication will have reduced odds of using opioids beyond 7 days. Methods: We completed a retrospective cohort study examining patients with T2DM who underwent forefoot amputation (toe, ray, transmetatarsal). Data were restricted to patients with a hemoglobin A 1c level less than 8.0% and an ankle-brachial index greater than 0.8. The outcome was use of postoperative opioids beyond 7 days. Patients received an initial opioid prescription of 7 days or less. We developed simple logistic regression models to identify the odds of a patient using opioids beyond 7 days by patient variables: age, race, sex, amputation level, body mass index, antidepressant medication use, and marital status. Variables with P , . 1 in the univariate analysis were included in the multiple logistic regression model. Results: Fifty patients met the inclusion criteria. Antidepressant use and marital status were the only statistically signi ﬁ cant variables. Adjusting for marital status, patients with antidepressant use had decreased odds (odds ratio, 0.018; 95% con ﬁ dence interval, 0.001 – 0.229; P = .002) of using opioids beyond 7 days after a diabetic forefoot amputation. Conclusions: Patients with T2DM who used antidepressants had signi ﬁ cantly reduced
) State

Abstract This article examines social transformation and mobility dynamics in Caracaraí, a rural frontier town in the State of Roraima, Brazil, from the 1950s to the 1990s. During this short period, we observe a rapid diversification of migration in Caracaraí: from non-migratory mobility tied to the micro-scale extraction of local products to more-permanent settlement in town, rapid shifts in the direction of internal migration patterns and back to non-migratory mobility patterns again. Drawing from frontier migration studies and mobility transition theories, this paper adopts a social transformation perspective to explore the relation between social change and these mobility transitions. The changing role of the state, from a promoter of infrastructure to a provider of services and public employment, the restructuring of the local economic fabric and its reorientation towards more secondary and tertiary activities, and inhabitants’ imaginaries of the development potential of Caracaraí all explain the shift in migration processes. Investigating these processes, we observe that (i) the state promoted new opportunities, leading to a decline in traditional circular mobility, alongside the growth of temporal workers and spontaneous migrants; (ii) infrastructure advancements encouraged non-migratory mobility patterns between Caracaraí and Boa Vista, the capital city of the State of Roraima; (iii) the provision of public employment intensified internal rural-urban and urban-rural migration patterns, from communities in the interior of the State of Roraima to Caracaraí and vice versa , and (iv) development imaginaries – the perception of how Caracaraí should and could be in the near future – prevented voluminous emigration, during periods of socio-economic slowdown. This research highlights the meaningful role of the state in altering livelihoods and migration decision-making processes. In particular, it shows how state expansion framed cultural imaginaries of the ‘good life’, favouring the desire to stay put in periods of high economic uncertainty, even when life aspirations were not being met by local opportunities.
Dengue Virus Neutralizing Antibody Levels Associated with Dengue Virus Neutralizing Antibody Levels Associated with Protection from Infection in Thai Cluster Studies Protection from Infection in Thai Cluster Studies

Background: Long-term homologous and temporary heterologous protection from dengue virus (DENV) infection may be mediated by neutralizing antibodies. However, neutralizing antibody titers (NTs) have not been clearly associated with protection from infection. Methodology/PrincipalFindings: Data from two geographic cluster studies conducted in Kamphaeng Phet, Thailand were used for this analysis. In the first study (2004–2007), cluster investigations of 100-meter radius were triggered by DENV-infected index cases from a concurrent prospective cohort. Subjects between 6 months and 15 years old were evaluated for DENV infection at days 0 and 15 by DENV PCR and IgM ELISA. In the second study (2009–2012), clusters of 200-meter radius were triggered by DENV-infected index cases admitted to the provincial hospital. Subjects of any age $ 6 months were evaluated for DENV infection at days 0
ESTIMATION OF GROUND REACTION FORCES FROM MARKERLESS KINEMATICS AND COMPARISON AGAINST MEASURED FORCE PLATE DATA

This study investigated how accurately ground reaction forces (GRFs) can be estimated from body centre of mass (BCOM) motion derived using markerless motion capture. Fifteen participants performed a countermovement jump (CMJ) on, and a running trial across, force plates. Kinematics captured using markerless and marker-based systems were used to drive IK-constrained OpenSim models. The resulting BCOM displacements were double differentiated to inversely estimate GRFs and compared to force plate data. Markerless-derived estimates were similar to measured GRFs (RMSD = ~70-150 N) and vertical peak force, impulse and rate of force development were also accurately estimated (effect sizes < 0.2), similarly to marker-based outputs. Our markerless workflow shows promise for the estimation of vertical GRF parameters out in the field, without markers or force plates.
Tabus or not taboos? How to use traditional environmental knowledge to support sustainable development of marine resources in Melanesia

These issues were discussed at a workshop on Traditional Knowledge and Coastal Resource Conservation for Countries and States of the Melanesian Spearhead Group, held at IMPAC (International Marine Project Activities Centre) in Townsville, Australia, in March/April 2004. The workshop sought to determine the underlying principles and themes that could be used to enhance the use and recognition of traditional knowledge and laws, with a goal of improving biodiversity conservation and management of coastal resources. The case studies from the workshop explore the links between customary laws — especially those relating to fisheries management — and existing government regulations, with a view to ensuring that government regulations take full account of customary practices. Melanesian case studies are complemented with case studies from other regions, which provide useful examples.
Die neue Definition und Klassifikation der pulmonalen Hypertonie

Zusammenfassung In der Neufassung der ESC/ERS-Leitlinien 2022 zur pulmonalen Hypertonie (PH) kam es zu wesentlichen Änderungen in der hämodynamischen Definition sowie zu einer weiteren Verfeinerung in der Klassifikation des Lungenhochdrucks. Als bedeutende Neuerung gilt die Einführung eines neuen Grenzwerts des mittleren pulmonalarteriellen Druckes (mPAP) für die Definition der PH. Eine PH wird nun durch eine Erhöhung des mPAP > 20 mmHg, ermittelt durch Rechtsherzkatheter, definiert. Des Weiteren wurde der Grenzwert des pulmonalen Gefäßwiderstands (PVR) zur Definition einer präkapillären PH verringert. Eine präkapilläre PH liegt nun bereits ab einem PVR > 2 WU und einem pulmonalarteriellen Verschlussdruck (PAWP) ≤ 15 mmHg vor. Die zunehmende Evidenz für die klinische Relevanz der pulmonalen Belastungshämodynamik führte schließlich auch zur Wiederaufnahme des Belastungs-PH-Terminus in die Leitlinien. Die Belastungs-PH wird als Verhältnis zum Herzzeitvolumen (CO) über einen pathologischen mPAP/CO-Slope > 3 mmHg/L/min definiert. In der Klassifikation werden weiterhin fünf Gruppen unterschieden: die pulmonalarterielle Hypertonie (Gruppe 1), PH assoziiert mit Linksherzerkrankungen (Gruppe 2), PH assoziiert mit Lungenerkrankungen und/oder Hypoxie (Gruppe 3), PH assoziiert mit pulmonalarterieller Obstruktion (Gruppe 4) und PH mit unklaren und/oder multifaktoriellen Mechanismen (Gruppe 5). In der folgenden Leitlinienübersetzung soll auf die Neuerungen eingegangen, deren Hintergründe näher beleuchtet und mögliche Schwierigkeiten in ihrer klinischen Anwendung diskutiert werden.
Teaching Tip: What You Need to Know about Gamification Teaching Tip: What You Need to Know about Gamification Process of Cybersecurity Hands-on Lab Exercises: Lessons and Process of Cybersecurity Hands-on Lab Exercises: Lessons and Challenges Challenges

Cybersecurity education is becoming increasingly important in modern society, and hands-on practice is an essential element. Although instructors provide hands-on labs in their cybersecurity courses, traditional lab exercises often fail to effectively motivate students. Hence, many instructors desire to incorporate gamification in hands-on training to engage and motivate cybersecurity students, especially beginner learners. Given the dearth of guiding examples, this paper aims to describe the holistic process of converting traditional cybersecurity hands-on lab exercises to gamified lab exercises in an undergraduate network security course. We find that the gamified cybersecurity lab promotes students’ engagement, learning experience, and learning outcomes. The results show the positive acceptance of gamification by students as well as instructors. While gamification has been used in competitions and training, the success in the classroom and students’ desire for more gamification show that further investment in gamification will be more important in the classroom. We expect this paper to help instructors who are interested in gamification 1) convert traditional lab exercises to gamified labs; 2) estimate the extra workload and potential benefits; and 3) plan resources for implementation. This process is applicable to any cybersecurity courses with hands-on assignments.
The Role of Work Engagement in Determining Job Satisfaction: Examining Work-Family Conflict and Work Stress

This study is expected to examine the effect of work-family conflict and stress on job satisfaction with work engagement as a mediating variable. The study population was Bank Rakyat Indonesia Rembang Branch employees. The number of samples is 108 employees. Data collection has employed a questionnaire. The results showed that the mediating role of work engagement caused work-family conflict not significantly to affect job satisfaction, and work stress did not significantly affect job satisfaction. Work engagement had a positive and significant effect on job satisfaction. Work engagement proved to mediate work-family conflict on job satisfaction. Work engagement can mediate job stress on job satisfaction.
Detecting telecom single photons with % system detection efficiency and high time resolution

Single photon detectors are indispensable tools in optics, from fundamental measurements to quantum information processing. The ability of superconducting nanowire single photon detectors (SNSPDs) to detect single photons with unprecedented efficiency, short dead time, and high time resolution over a large frequency range enabled major advances in quantum optics. However, combining near-unity system detection efficiency (SDE) with high timing performance remains an outstanding challenge. In this work, we fabricated novel SNSPDs on membranes with ( 99.5 + 0.5 − 2.07 ) % SDE at 1350 nm with 32 ps timing jitter (using a room-temperature amplifier)