Miracle-dz/UniFAR-FTUs huggingface dataset:
Can We Reboot the Role of Intraperitoneal Chemotherapy in the Treatment for Gastric Cancer with Peritoneal Carcinomatosis?: A Retrospective Cohort Study Regarding Minimally Invasive Surgery Conjoined with Intraperitoneal plus Systemic Chemotherapy

Simple Summary The prognosis of gastric cancer (GC) patients with peritoneal carcinomatosis (PC) remains poor, in spite of the recent evolution of systemic chemotherapy for patients with GC. Nowadays, as intraperitoneal (IP) chemotherapy has been applied in the treatment for GC patients with PC, several promising data have been suggested. Inspired by the known characteristics of minimally invasive surgery (MIS), we have recently applied MIS concept in IP and systemic chemotherapy for GC patients with PC. We retrospectively compared the clinical outcomes between the patients underwent MIS conjoined IP plus systemic chemotherapy and patients underwent systemic chemotherapy only, to show the promising potential of the new treatment strategy combining MIS concept with IP plus systemic chemotherapy for GC patients with PC. Abstract Background: Peritoneal carcinomatosis (PC) is the most common form of metastasis in gastric cancer (GC) and is related with a poor prognosis. Several treatment modalities including systemic chemotherapy and intraperitoneal chemotherapy have been studied and adopted in treatment of GC patients with PC. Nevertheless, few studies have reported the comparison of the oncologic outcomes between minimally invasive surgery (MIS) with intraperitoneal (IP) chemotherapy and conventional chemotherapy for GC with PC. Methods: We retrospectively reviewed the clinical records of 74 patients who had been diagnosed as GC with PC via either intra-abdominal exploration or abdominopelvic computed tomography between January 2011 and April 2021. After performing propensity score-matching for this retrospective data, we compared the outcomes of 26 patients who underwent MIS followed by IP combined systemic chemotherapy (MIS-IP group) and 26 patients who underwent systemic chemotherapy only (SC-only group). Results: The 2-year progression free survival rate of the MIS-IP group was significantly higher than the SC-only groups (36.4% and 10.5%, respectively; p = 0.010). In multivariate analysis to detect relevant factors on PFS, IP chemotherapy (HR 0.213; p < 0.001), Eastern Cooperative Oncology Group performance status (HR 3.689; p = 0.002), and the amount of ascites (p = 0.011) were significant prognostic factors. Conclusions: This study demonstrated the therapeutic potential of MIS conjoined IP plus systemic chemotherapy for GC patients with PC. MIS conjoined by IP plus systemic chemotherapy can be adopted as a treatment option to reboot the role of IP chemotherapy in GC patients with PC.
Hate Speech in Asia and Europe: Beyond Hate and Fear, Myungkoo Kang, Marie-Orange Rivé-Lasan, Wooja Kim and Philippa Hall (eds) (2020)

Review of: Hate Speech in Asia and Europe: Beyond Hate and Fear, Myungkoo Kang, Marie-Orange Rivé-Lasan, Wooja Kim and Philippa Hall (eds) (2020) Oxford: Routledge, 206 pp., ISBN 978-0-36720-900-1, h/bk, £120.00
ERP Projects in Organizations with Low Maturity in BPM: A Collaborative Approach to Understanding Changes to Come

: ERP projects are constantly involved with profound changes in organizations that directly impact business processes and their stakeholders. Therefore, process understanding is an essential step in such projects. However, in companies with low maturity levels in BPM, the processes are informal and unstructured; there are no previous models or outdated. Thus, the primary source of information about processes is the people involved in their execution. But, how to engage ERP project stakeholders in the changes resulting from the new system by understanding current processes and future changes? This study proposes a framework called "Meet2Map" to answer this question. This approach promotes identifying, discovering, and modeling processes involving participants based on collaborative interactions and human-centered design principles. Through a case study, the results showed the adequacy of the Meet2Map framework in supporting the process analyst in As-Is process modeling as an essential step in the implantation of ERP systems.
Interrelationships among feather mercury content, body condition and feather corticosterone in a Neotropical migratory bird, the Purple Martin (Progne subis subis).

Purple Martins (Progne subis) are migratory birds that breed in North America and overwinter and complete their molt in South America. Many of the breeding populations are declining. The eastern North American subspecies of Purple Martin (P. subis subis) comprises >90% of all Purple Martins. This subspecies overwinters and molts in the Amazon Basin, a region that is high in mercury (Hg) contamination, which raises the possibility that observed declines in Purple Martins could be linked to Hg exposure. Exposure to Hg results in numerous and systemic negative health outcomes, including endocrine disruption. Corticosterone (CORT) is a primary modulator of the stress and metabolic axes of vertebrates; thus, it is important in meeting metabolic and other challenges of migration. Because feathers accumulate Hg and hormones while growing, quantification of Hg and CORT in feathers provides an opportunity to retrospectively assess Hg exposure and adrenal activity of birds using minimally invasive methods. We evaluated interrelationships among concentrations of total Hg (THg) and CORT in feathers that grew in the Amazon Basin and body condition (mass, fat score) of these birds in North America. Concentrations of THg in Purple Martin feathers ranged from 1.103 to 8.740 μg/g dw, levels associated with negative physiological impacts in other avian species. Concentrations of CORT did not correlate with THg concentration at the time of feather growth. However, we found evidence that THg concentration may negatively impact the ability of Purple Martins to accumulate fat, which could impair migratory performance and survivorship due to the high energy requirements of migration. This finding suggests potential carryover effects of Hg contamination at the wintering grounds in the Amazon to the summer breeding grounds in North America.
Neurogenetic modeling of energy demand in the United Arab Emirates, Saudi Arabia, and Qatar

Socio‐economic variables including gross domestic product, population, and energy and electricity production are used in modeling and forecasting national energy demands of the United Arab Emirates, Saudi Arabia, and Qatar. The proposed model features: (i) the nonlinear component of energy demand (removal of linear trend), (ii) application of double exponential smoothing method for input data projection, and (iii) genetic algorithm‐based artificial neural network (ANN) models. The proposed neuro‐genetic model performed very well for the three selected countries. The coefficient of determination and Willmott's index of agreement for the training and testing dataset are quite high whereas the mean absolute error, mean absolute percentage error and root mean squared error are quite low. The acceptable agreements between the observed energy consumption and the model predictions revealed its viability for the study of energy demand in the three selected member states of the energy exporting regional alliance Gulf Cooperation Council (GCC). © 2017 American Institute of Chemical Engineers Environ Prog, 36: 1208–1216, 2017
Design and Study of a Miniaturized Millimeter Wave Array Antenna for Wireless Body Area Network

A miniaturized millimeter wave (mmWave) antenna for wireless body area networks is proposed in this paper. The antenna is found to be operational in the V-band, around the 60 GHz frequency range, with high efficiency of up to 99.98% in free space simulations. A multilayer, thin substrate was implemented in the design to enhance radiation efficiency and gain. The antenna seems to be most suitable for small electronic devices and wireless body area network (WBAN) applications because of its low profile and lighter weight concept. To enhance its performance, several arrays of different orders were created. The Parallel-Fed and Tapered Feed Line methods were followed to design the planar arrays with 1 × 2, 1 × 4, and 2 × 2 elements in the primary design. Free space results were compared, and a 2 × 2 element array was found to be the most balanced according to the simulations. To justify the eligibility of these designs for WBAN applications, a virtual human body model was created within the 3D computer-simulated environment and the simulations were repeated, where four equal-spaced distances were taken into account to identify the antenna and its array behavior more accurately. Simulations returned optimistic results for the 2 × 2 element planar array arrangement in almost all parameters, even when placed close to the human body at any distance greater than 2 mm.
A Mathematical Analysis on the New Fractal-Fractional Model of Second-Hand Smokers via the Power Law Type Kernel: Numerical Solutions, Equilibrium Points, and Sensitivity Analysis

The second-hand smoke is a phenomenon that needs to be investigated, and its effects on the health of the people are to be examined. To analyze such an issue, the mathematical models are the best tools that help us to study the dynamical behaviors of this phenomenon. For this purpose, in the present paper, we consider a three-compartmental fractal-fractional mathematical model of a specific population of smokers or people that are exposed to second-hand smoke. By assuming some conditions on ϕ - ψ -contractions and compact operators, we prove some theorems in relation to the existence of solutions. The Banach principle for the usual contractions is used for proving the uniqueness of solutions. Next, by some notions of functional analysis, two types of Ulam-Hyers stability for the fractal-fractional second-hand smoker model are established. Moreover, we have a steady-state analysis and obtain equilibrium points and basic reproduction number R 0 . Then, we investigate the sensitivity of the fractal-fractional system with respect to each parameter. For numerical simulation, the Adams-Bashforth (AB) method is used to derive numerical schemes for plotting and simulating the approximate solutions. Finally, the obtained solutions are tested with real data and different values of fractal dimensions and fractional orders.
Lemon Juice Formulations Modulate In Vitro Digestive Recovery of Spinach Phytochemicals

SUMMARY Research background Citrus limon (L.) Burm lemon juice is rich in many important natural chemical components (flavonoids, citric acid and vitamin C) and its use in traditional medicine is well known. Formulations of lemon juice with fruit polyphenols in beverages have been investigated, but there is very little information about their ability to modulate the digestive behaviour of polyphenols. The goal of this study is to determine the stability and digestive availability of spinach (Spinacia oleracea L.) polyphenols by adding different volume fractions of lemon juice (0, 2, 5, 10 and 20%) during in vitro digestion. Experimental approach The content of polyphenols and other abundant compounds including nitrates, oxalic acid and l-ascorbic acid in spinach formulation with various volume fractions of lemon juice were measured in predigested and digested samples using in vitro human digestion model. Antioxidant and α-amylase inhibitory activities of spinach lemon juice formulation were also measured. Results and conclusions The highest increases in total polyphenols, total flavonoids, total phenolic acids, oxalic acid and nitrate content were noted in predigested and almost all digested spinach samples formulated with the highest volume fraction of lemon juice. In the same sample, the content of individual compounds significantly increased after salivary (l-ascorbic acid), initial (p-coumaric acid) and intestinal (quercetin) phase of digestion. High bioaccessibility of polyphenols and l-ascorbic acid in all phases of digestion was observed in almost all spinach lemon juice formulations, with the exception of nitrates in gastric and intestinal phases and oxalic acid in the intestinal phase, which had moderate bioaccessibility. Novelty and scientific contribution For the first time the stability and digestive availability of spinach polyphenols, oxalic acid, nitrates and l-ascorbic acid were tested with the addition of different volume fractions of lemon juice. The pH of lemon juice and its l-ascorbic acid content increase the stability and availability of polyphenols in spinach lemon juice formulation during in vitro digestion. Antioxidant and α-amylase inhibitory activities increase in dose-dependent manner after lemon juice addition. Accordingly, spinach formulated with 20% of lemon juice appears as the best source of dietary polyphenols with antioxidant and antidiabetic activities and nitrates that may be used as a functional drink.
Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer

Simple Summary Carcinoma associated fibroblasts (CAF) play a critical role in the tumor microenvironment (TME) of prostate cancer (PCa). Ephrin receptors (Eph) and ligands (EFN) have been implicated in distinct types of cancers. Alterations on EphB receptors are frequently found in PCa, but the role of ligands (EFNB1, EFNB2, EFNB3) activation in prostate fibroblasts and consequent effects on PCa is not known. We found increased EFNB ligands in fibroblasts isolated from PCa tissues. In this study, we assessed the effects of elevated stromal EFNB ligands on PCa tumor growth. Increased EFNB1 and EFNB3 expression transformed normal fibroblasts into CAF phenotypes through activation of Src family kinases. The secretome of EFNB-expressing CAF increased PCa cell proliferation and promoted TME remodeling. Overall, EFNB activation in CAF may participate in PCa progression via the release of soluble factors that modulate the surrounding tumor environment, which, in turn, promote prostate tumor growth and invasion. Abstract Through stromal-epithelial interactions, carcinoma associated fibroblasts (CAF) play a critical role in tumor growth and progression. Activation of erythrophoyetin-producing human hepatocellular (Eph) receptors has been implicated in cancer. Eph receptor interactions with Ephrin ligands lead to bidirectional signals in the recipient and effector cells. The consequences of continuous reverse Ephrin signaling activation in fibroblasts on prostate cancer (PCa) is unknown. When compared to benign prostate fibroblast, CAF displayed higher expression of Ephrin B1, B2, and B3 ligands (EFNB1, EFNB2, and EFNB3). In this study, we found that continuous activation of EFNB1 and EFNB3 in a benign human prostate stromal cell line (BHPrS1) increased the expression of CAF markers and induced a CAF phenotype. BHPrS1EFNB1 and BHPrS1EFNB3 displayed a pro-tumorigenic secretome with multiple effects on neovascularization, collagen deposition, and cancer cell proliferation, overall increasing tumorigenicity of a premalignant prostate epithelial cell line BPH1 and PCa cell line LNCaP, both in vitro and in vivo. Inhibition of Src family kinases (SFK) in BHPrS1EFNB1 and BHPrS1EFNB3 suppressed EFNB-induced ɑ-SMA (Alpha-smooth muscle actin) and TN-C (Tenascin-C) in vitro. Our study suggests that acquisition of CAF characteristics via SFK activation in response to increased EFNB ligands could promote carcinogenesis via modulation of TME in PCa.
Epidemiological Characteristics of COVID-19 Cases in Non-Italian Nationals in Sicily: Identifying Vulnerable Groups in the Context of the COVID-19 Pandemic in Sicily, Italy

As in other parts of the world, undocumented migrants in Italy suffer worse health status due to their immigration enforcement situation and other vulnerabilities such as precarious illegal jobs, exploitation and abuse or barriers to higher education, with higher prevalence of chronic noncommunicable diseases. The COVID-19 pandemic, as other pandemics, has not affected everyone equally. The undocumented was one of the most affected groups with regard to hospitalization rates and mortality worldwide. Sicily is one of the gates of entrance to Europe for migrants and asylum seekers from Africa and Asia. Herein, we described the epidemiological characteristics of COVID-19 cases in Sicily to compare hospitalization rate and mortality between Italian nationals and foreigners. We extracted data from the integrated national surveillance system established by the Italian National Institute of Health (Istituto Superiore di Sanità, ISS) to collect information on all COVID-19 cases and deaths in Sicily. We found that the hospitalization rates were higher in undocumented foreigners, and they were most likely to present a more severe clinical outcome compared to Italian nationals. Inclusive public health policies should take this population group into consideration to achieve the Health for All goal.
PRODUCT KNOWLEDGE DAN PRODUCT PROMOTION TERHADAP PURCHASE SATISFACTION DAN REPURCHASE INTENTION SELAMA PANDEMIC COVID-19

The Covid-19 pandemic has fundamentally changed the world. The pandemic is forcing consumers to change their buying attitudes and habits (Blackburn, 2020). Recent studies have begun to focus more on the market perspective by investigating consumer vulnerability from the perspectives of poverty and low incomes (Glavas et al., 2020), decision making (Choudhury et al., 2019; Hill & Sharma, 2020), and markets (Stewart & Yap. , 2020). This study aims to explain this aspect. This research is a quantitative research and the respondents in this research are 100. In this study, the sample was taken by non-probability sampling, namely by using the accidental sampling technique. Based on data analysis, it is known: H1 is accepted, there is an effect of Product Knowledge on Purchase Satisfaction, H2 is accepted: there is an effect of Product Knowledge on repurchase intention, H3 is accepted: there is an effect of Product Promotion on Purchase Satisfaction, H4 is accepted: there is an effect of Product Promotion on Repurchase Intention and H5 is accepted. : there is an influence between Purchase Satisfaction on repurchase intention. Keywords: product knowledge, product promotion, Purchase Satisfaction, repurchase intention
An Extensible Framework for Data Reliability Assessment

: Data Warehouse (DW) and Data Lake (DL) systems are mature and widely used technologies to integrate data for supporting decision-making. They support organizations to explore their operational data that can be used to take competitive advantages. However, the amount of data generated by humans in the last 20 years increased exponentially. As a result, the traditional data quality problems that can compromise the use of analytical systems, assume a higher relevance due to the massive amounts and heterogeneous formats of the data. In this paper, an approach for dealing with data quality is described. Using a case study, quality metrics are identified to define a reliability indicator, allowing the identification of poor-quality records and their impact on the data used to support enterprise analytics.
The Influence of the Hypergravity Field During Bubble Ripening in Porous Media

With the development of carbon dioxide geological storage, the Ostwald ripening process in pores has attracted the attention of researchers due to its application to storage stability problems. However, this process is difficult to reproduce accurately in the laboratory due to the large mass transfer time scale. This article utilizes two theoretical models of gravity‐induced ripening to analyze the influence of the hypergravity field on the process. It is concluded that a decades‐long mass transfer process can be shortened to 10 days if the acceleration of gravity is increased by 1,000 times. Moreover, if the scaling laws are considered, a scaled hypergravity model can be used to reproduce long‐term and large‐scale geological phenomena in a short period, facilitating future research on the Ostwald ripening process in hypergravity centrifuges.
MPO–ANCA-Positive Granulomatosis with Polyangiitis with Rapidly Progressive Glomerulonephritis and Saddle-Nose Deformity: A Case Report

Early diagnosis and initiation of appropriate immunosuppressive treatment remain the cornerstone of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis at the cost of significant toxicity. In this report, we present a case of a 69-year-old female who presented with advanced renal insufficiency and evidence of pulmonary hemorrhage and was MPO–ANCA-positive with a clinical phenotype of granulomatosis with polyangiitis. Organ involvement included rapidly progressive glomerulonephritis (GN), along with extrarenal manifestations (skin, upper and lower respiratory system involvement, and onset of saddle-nose deformity). Kidney biopsy established the diagnosis of pauci-immune crescentic, sclerotic GN. She received therapy with glucocorticoids and cyclophosphamide, mainly due to life-threatening extra-renal manifestations, such as pulmonary hemorrhage. She avoided vasculitis-related death but she developed severe therapy-related toxicity, resulting in the discontinuation of immunosuppressive therapy. Continuous re-evaluation of patients with ANCA-associated vasculitis in terms of response to immunosuppressive therapy and treatment-related toxicity is crucial for their management.
PHAST: Hierarchical Concurrent Log-Free Skip List for Persistent Memory

Skip list (skiplist) is a competitive index structure that offers superior concurrency and excellent performance but with high memory overhead and low access locality. Emerging persistent memory (PM) technologies present an opportunity to mitigate the capacity constraint of DRAM. However, data consistency in PM typically results in excessive write overheads. In addition, fast concurrent access to an index is critical to the throughput on high-end contemporary computer systems. In this paper, we propose a Partitioned HierArchical SkiplisT called PHAST, which can simultaneously reduce the skiplist height and improve its access locality, through its hierarchy of component structures, while enabling fast parallel recovery in case of failure. To ensure high concurrency and fast data consistency, we also have developed writelock-free failure-atomic concurrent insert and log-free atomic split. Furthermore, we have developed a durable lock-free concurrent search that can discern transient structural inconsistencies and deliver highly concurrent read operations. We have conducted an extensive evaluation of PHAST compared to state-of-the-art studies such as NV-Skiplist, wB+-Tree, FPTree, and FAST-FAIR. Our evaluation results show PHAST outperforms other indexing structures by up to 2.75 and 1.86 in single threaded inserts and searches, and achieves 1.56 and 2.62 improvements in concurrent inserts and searches.
Smart System Resource Coordination Algorithm Based on 6G Technology

Most of the existing resource allocation algorithms do not take into account the restriction conditions such as the delay limitation of different services and the service volume requirements of different STAs. Moreover, the surge in the number of smart terminal devices has brought great challenges to the access effect of WLAN systems. Therefore, 6G technology will surely replace the current technology as the main means of future communication technology. This paper combines 6G technology to study the smart system resource coordination algorithm and analyzes the calculation process and actual effect of the algorithm. Moreover, this paper analyzes the coordination of smart system resources and verifies the effect of 6G technology in the coordination of smart system resources through experimental research. The results of experimental research show that the smart system resource coordination algorithm based on 6G technology can effectively improve the resource coordination effect of smart systems and has certain anti-interference, which will promote the construction of smart systems in the future.