Miracle-dz/UniFAR-FTUs huggingface dataset:
Complete genome for Actinobacillus pleuropneumoniae serovar 8 reference strain 405: comparative analysis with draft genomes for different laboratory stock cultures indicates little genetic variation

We report here the complete genome sequence of the widely studied Actinobacillus pleuropneumoniae serovar 8 reference strain 405, generated using the Pacific Biosciences (PacBio) RS II platform. Furthermore, we compared draft sequences generated by Illumina sequencing of six stocks of this strain, including the same original stock used to generate the PacBio sequence, held in different countries and found little genetic variation, with only three SNPs identified, all within the degS gene. However, sequences of two small plasmids, pARD3079 and p405tetH, detected by Illumina sequencing of the draft genomes were not identified in the PacBio sequence of the reference strain.
SocioCultural and Religious Impacts Upon Covid-19 Pandemic Physical Distancing Public Practices

Introduction COVID-19 is the first pandemic event that has happened in Oman which requires all residents and nationals to practice quarantine and physical distancing. Methods This cross-sectional study targeted the population of Oman and was carried out during the first wave of the COVID-19 pandemic from 11th August 2020 to 7th September 2020. This study utilized the online survey most appropriately designed for the population. The survey was distributed to the public through social media and text messages. The survey was translated into the four main spoken languages in Oman, which are Arabic, English, Swahili, and Hindi. Results A total of 943 residents responded to the online survey. The majority of respondents reported that they are ready/ready to a great extent to practice physical distancing (61.9%) during the pandemic compared to 34.9% not sure/ready to some extent and 3.2% not ready at all for physical distancing. It was found that financial factors, religious and cultural-norms had the strongest negative-impact to maintain physical distancing. While level of responsibility, governmental legislations, and fear of getting or transmitting the infection had the strongest positive impact to maintain physical distancing. Males reported a greater financial and religious negative impact of physical distancing with p-values of 0.002 and 0.001, respectively. Females reported a greater positive impact of family and friend's support and legislation with p-values of 0.046 and 0.008, respectively. Conclusion Religious practices mainly negatively affected the male gender during this pandemic which hindered the adherence to physical distancing. This could be due to culture and norms that derive from human behavior within communities and may affect the safety measures during an outbreak or pandemic. Hence, even with availability of vaccinations, campaigns on public health and the utilization of faith leaders should be the national practice to continue emphasizing compassionate attitudes towards physical distancing.
High-performance direct torque control of an induction motor

A novel direct torque control method for an induction motor is presented which is quite different from field-oriented control. Improving the torque response of a large-capacity induction motor using two sets of three-phase inverters and an open-data induction motor is of special concern. Instantaneous voltage vectors applied by an inverter have redundancy characteristics which provide some flexibility for selecting the inverter switching modes. By using this switching freedom, control is achieved according to the following priorities: (1) high-speed torque control; (2) regulation of the primary flux; (3) decreasing the zero phase sequence current; and (4) minimization of the inverter switching frequency. Simulations and experiments have been carried out to verify the feasibility of this priority control, accompanied by comparisons with another control scheme. Torque frequency-response corner frequencies above 2000 Hz have been experimentally measured, and time constants of 4 ms have been achieved for rotor-speed step responses from -500 to 500 r/min. The peak transient torque during the step change is about 20 times the rate torque. >
Establishing ergonomics in the People's Republic of China

Abstract In this paper a summary of the Chinese Ergonomics Society (CES) is introduced. The main ergonomics institutions in China re presented. Some important research projects that are being or have been investigated are mentioned. The teaching of ergonomics in Chinese universities is described. Several titles of publications written by Chinese ergonomists are listed. The characteristics of the ergonomic situation in China are discussed.
The Opportunity for Energy Efficiency with Clean Air Regulations

Four air quality requirements from the U.S. Environmental Protection Agency (EPA) include the: (1) National Ambient Air Quality Standards (NAAQS), (2) Cross-State Air Pollution Rule (CSAPR), (3) Mercury and Air Toxics Standards (MATS), and (4) Boiler MACT. The NAAQS specify maximum ambient concentrations of six air pollutants, while CSAPR and MATS require significant reductions in pollution from certain electric generating units (EGUs) – the country’s largest sources of SO2 and of mercury emissions, and the largest stationary sources of NOX emissions. Boiler MACT sets emissions limits and other requirements on industrial, commercial, and institutional boilers. Each of these regulations offers an important opportunity to expand the use of well-known, proven, and cost-effective energy efficiency 1 . With the NAAQS, states can use efficiency as a direct strategy to achieve emissions reductions necessary for meeting the standard. Under CSAPR, a market-based emissions trading program, power plants that improve their generating efficiency will correspondingly reduce the tons of SO2 and NOX they emit, thereby reducing the number of CSAPR allowances required to surrender for compliance 2 . MATS includes alternative output-based standards for existing sources and primary emission standards for new sources, including provisions for combined heat and power (CHP), or cogeneration units. In addition to opportunities for new-source efficiency improvements within the MATS rule, recent EPA power-sector modeling illustrates the important complementary benefits of state policies to support demand-side efficiency improvements. These benefits include lowering total compliance costs for MATS, reducing ratepayer bills over the long term, and in some cases, delaying or avoiding the need for equipment upgrades or new construction of generating facilities and emissions controls. The Boiler MACT 3 also includes alternative output-based standards that recognize improvements in boiler efficiency (including use of CHP), as well as a provision for boiler tune-ups and facilitywide energy assessments in affected facilities. The purposes of this paper are to: briefly describe these regulations; document the opportunity with each regulation to employ efficiency; and describe the steps EPA is taking to help state and municipal governments plan for and use energy efficiency as a strategy to reduce emissions and improve air quality. The paper concludes with several no-regrets options that these jurisdictions can consider.
RNA-binding protein Orb2 causes microcephaly and supports centrosome asymmetry in Drosophila neural stem cells

To maintain a balance of self-renewal versus neurogenesis, neural stem cells (NSCs) undergo asymmetric cell division along an invariant polarity axis instructed by centrosomes. In the NSCs of the third instar Drosophila larval brain, the interphase centrosomes are defined by marked asymmetries in protein composition and functional activity as microtubule-organizing centers. Here we show that a conserved RNA-binding protein, Orb2, supports NSC centrosome asymmetry by localizing to the cytoplasm, where it promotes robust apical centrosome maturation and transient basal centrosome inactivation, required for centrosome segregation and spindle morphogenesis. Orb2 is required cell autonomously within NSCs to support centrosome asymmetry and maintenance of the stem cell pool. We suggest Orb2 plays opposing roles in centrosome activation and inactivation at the apical versus basal centrosomes respectively, possibly through the translational regulation of multiple mRNAs. Conversely, loss of orb2 manifests in microcephaly independent of Orb2 function in NSCs. Bioinformatics uncovers a significant overlap among RNA targets between Drosophila Orb2 and human CPEB4, consistent with a conserved role for CPEB proteins in centrosome regulation and neurodevelopment.
Biocompatibility Analyses of HF-Passivated Magnesium Screws for Guided Bone Regeneration (GBR)

Background: Magnesium (Mg) is one of the most promising materials for human use in surgery due to material characteristics such as its elastic modulus as well as its resorbable and regenerative properties. In this study, HF-coated and uncoated novel bioresorbable magnesium fixation screws for maxillofacial and dental surgical applications were investigated in vitro and in vivo to evaluate the biocompatibility of the HF coating. Methods: Mg alloy screws that had either undergone a surface treatment with hydrofluoric-acid (HF) or left untreated were investigated. In vitro investigation included XTT, BrdU and LDH in accordance with the DIN ISO 10993-5/-12. In vivo, the screws were implanted into the tibia of rabbits. After 3 and 6 weeks, degradation, local tissue reactions and bony integration were analyzed histopathologically and histomorphometrically. Additionally, SEM/EDX analysis and synchrotron phase-contrast microtomography (µCT) measurements were conducted. The in vitro analyses revealed that the Mg screws are cytocompatible, with improved results when the surface had been passivated with HF. In vivo, the HF-treated Mg screws implanted showed a reduction in gas formation, slower biodegradation and a better bony integration in comparison to the untreated Mg screws. Histopathologically, the HF-passivated screws induced a layer of macrophages as part of its biodegradation process, whereas the untreated screws caused a slight fibrous tissue reaction. SEM/EDX analysis showed that both screws formed a similar layer of calcium phosphates on their surfaces and were surrounded by bone. Furthermore, the µCT revealed the presence of a metallic core of the screws, a faster absorbing corrosion front and a slow absorbing region of corroded magnesium. Conclusions: Overall, the HF-passivated Mg fixation screws showed significantly better biocompatibility in vitro and in vivo compared to the untreated screws.
Approximate Bayesian Estimation of Stochastic Volatility in Mean Models using Hidden Markov Models: Empirical Evidence from Stock Latin American Markets

El modelo de volatilidad estocástica en la media (SVM) propuesto por Koopman and Uspensky (2002) es re- visado. Este documento tiene dos objetivos. El primero es ofrecer una metodología que requiere menos tiempo computacional en simulaciones y estimaciones comparadas con otras propuestas en la literatura como en Abanto- Valle et al. (2021) y otros. Para lograr el primer objetivo, proponemos aproximamos la función de verosimilitud del modelo SVM aplicando Hidden Markov Models (HMM) para hacer posible la inferencia bayesiana en tiempo real. Tomamos muestras de la distribución posterior de los parámetros usando una distribución Normal mul- tivariada con media y varianza dadas por la moda posterior y la inversa de la matriz Hessiana evaluada en esta moda posterior usando importance sampling (IS). Usando simulaciones, las propiedades frecuentistas de los estimadores son analizadas. El segundo objetivo es proporcionar evidencia empírica estimando el modelo SVM utilizando datos diarios para cinco mercados bursátiles de América Latina. Los resultados indican que la volatilidad impacta negativamente en los rendimientos sugiriendo que el efecto de retroalimentación de la volatilidad es más fuerte que el efecto relacionado con la volatilidad esperada. Este resultado es exacto y opuesto al hallazgo de Koopman and Uspensky (2002). Nosotros comparamos nuestra metodología con los algoritmos de Hamiltoniano Montecarlo (HMC) y Riemannian HMC basados en Abanto-Valle et al. (2021).
RandD Investment in the Priority Technologies of the European Strategic Energy Technology Plan

The present report estimates the current RD photovoltaic and concentrating solar power; carbon dioxide capture and storage ; smart grids; hydrogen and fuel cells; transport biofuels; nuclear fission and fusion. A novel approach has been developed to estimate corporate R&D investments by technology, combining available data with other publicly available information and with expert judgment. With regard to public R&D investments, information from existing databases (Eurostat and the IEA) has been complemented and improved through the direct contact with Member States. On this basis and despite some associated uncertainties, the current R&D efforts in Europe dedicated to SET-Plan priority technologies are approached and policy-relevant conclusions are derived.
Three-Dimensional Reconstruction of Cerebrovascular and Algorithm Realization

Objective In the three-dimensional reconstruction of CT cerebrovascular medical image registration, a new optimization algorithm based on the relative position information between the contours of various blood vessels in the image is proposed. Methods Using the rule that the center of gravity of the vascular tissue structure on the series of slices has continuity, find the registration relationship between the contours of the vessels in the two adjacent slices. Because the shape of cerebrovascular contour is relatively symmetrical, its center of gravity is slightly away from its geometric center. Therefore, the geometric center is used to replace the center of gravity, and the “mass” of each contour is calculated according to the area of each contour to achieve the registration of the blood vessel contour. Results The method has the characteristics of global optimization and stronger robustness. Conclusion The cerebrovascular image obtained by this method is more realistic and can be used for the import of various software, simulation training, and later research, which provides an effective method for preoperative simulation of cerebrovascular intervention surgery.
Robust noncooperative attitude tracking control for rigid bodies on rotation matrices subject to input saturation constraint

This paper addresses the noncooperative attitude tracking control problem for rigid bodies whose dynamics evolves on the rotation matrix SO(3) . First, based on the relative attitude measurement, a saturated angular velocity input is designed by a proposed saturated nonlinear function. Thereafter, the attitude tracking control torque for rigid body's dynamics with input saturation constraint and active disturbance rejection is developed by a modified dynamic surface control approach which can avoid large torque in practice. Furthermore, by using only relative attitude measurements, two types of velocity‐free attitude control laws are considered, respectively. In contrast to those control schemes that require that the desired angular velocity is available to the rigid body, the proposed scheme is able to solve the attitude control in noncooperative scenarios, where the desired angular velocity and acceleration are not accessible. Since the attitude described by rotation matrix SO(3) enables the controller to use local measurements in the body‐fixed frame rather than global measurements in an inertial frame, the proposed robust noncooperative control schemes with input saturation constraint are easier to implement in practice. Finally, numerical simulations and SimMechanics experiments are provided to illustrate the effectiveness of the proposed theoretical results.
Developing an Online Course: Reflections on the Process

A postgraduate course for registered nurses working in a National Corrections Service was developed by relatively novice instructional designers. This occurred within an organisation that could access only limited financial and technological resources to support the development. This paper follows this fully online course from its inception through to its delivery, exploring the journey to create a pedagogically sound course that met the needs of the particular healthcare sector. This programme has now become a showpiece for the organisation, and the development process tapped the previously unrealised potential of the teaching team.
Conexões entre processos morfofonológicos e acento em Manxineru : a variedade Yine (família Aruák) falada no Brasil

This PhD dissertation investigates, by means of experimental acoustic phonetics, the interface of phonology and morphology in the Manxineru language, a variant of Yine (Macho-Piro, Aruák family) spoken in Brazil. Manxineru has 1106 speakers living in 12 villages at Mamoadate Indigenous Land, Southwestern of Acre state, in Brazil. This dissertation deepens the study by Couto (2012) on the syllabic and rhythmic patterns of Manxineru. We present a brief discussion of the main works on the Piro variant spoken in Peru (MATTESON, 1965; HANSON, 2010), which have been the main references in our mophological and morphosyntatic analysis of Manxineru. We also present a description of aspects of Manxineru morphology and morphosyntax (syntax), as our focus is their interface with the phonology and the main prosodic patterns of that language. We made use of experimental acoustic methodologies to examine a range of morphophonological processes found in Manxineru. We also analyzed prosodic aspects of the language, demonstrating that morphophonological processes matches rhythmic principles controlling the phonological forms of words. We have based our phonological and prosodic analyzes on Pike (1943, 1947), Jakobson, (1952); Trubetzkoy ([1939] 1976)), Chomsky & Halle (1968), Clements & Hume (1995), Halle & Vergnaud (1987), Nespor & Vogel (1986), Bisol (2010) and Hayes (1995, 1981, 1991). Conseriu (1972), Dixon (1979, 1995), Comrie (1976, 1981, 1984), Aikhenvald & Dixon (1999), Rodrigues (1953, 2002) and Aikhenvald (1999a, 1999b) have been the main references for our morphosyntatic analyses of Manxineru. Other references have been Pierrehumbert (1980), Barbosa & Madureira (2015) and Ramirez (2001). As to the prosodic analysis, the metrical theoretical model by Hayes (1981, 1995), Selkirk (1978, 1984, 1995) and Ladd (1996) have been of great importance. Finally, the works by Matteson (1965) and Lin (1997) on Manxineru phonology have been very useful in the study of Yine phonology and prosody. For experimental acoustic phonetics, we considered mainly Ladefoged (1975, 1995, 2001), Ladefoged & Maddieson (1996), Kent & Read (2015), Stevens (1998) and Barbosa & Madureira (2015).
All-fiber passively mode-locked ytterbium fiber laser with a rectangular spectrum profile

We have demonstrated an all-fiber passively mode-locked ytterbium fiber laser operating with a rectangular spectrum profile. Mode-locking is achieved by adopting nonlinear polarization rotation (NPR) in an all fiber ring cavity with normal dispersion. The 3 dB bandwidth of the spectrum is 8.6 nm, the signal-to-noise ratio (SNR) is more than 40 dB, and the rising and falling band edges are very steep. The mode-locking pulse train is stable and has a repetition of 13.4 MHz. We believe that the laser is operating in the gain-guided soliton state, which means soliton formation is induced purely by the existence of gain and gain dispersion. This kind of mode-locked fiber laser with the rectangular spectrum has potential applications in optical-based ultra-high-speed signal collection system, optical frequency combs generation and supercontinuum light source.
Preliminary Study On The Data Mining of Prescriptions Containing Schisandra And The Mechanism of Diabetes

Background: Data mining builds a bridge between ancient books of traditional Chinese medicine and modern medicine. It provides a new perspective for the precise compatibility of prescriptions and the scheme of diagnosis and treatment. Meanwhile, the mechanism of schisandrae chinensis and its compound in treating diabetes and diabetic complications is not clear. This limits the clinical application of Schisandra chinensis. Methods: Apply TCMISS to mine the core drugs with the highest frequency of combined use with Schisandra chinensis to form a new prescription. And analyze the compatibility law. Use databases such as TCMSP, TCMID, PubChem, Swiss arget prediction, disgenet and Cytoscape software. The interaction between drugs and diseases and related pathways were analyzed. In addition, autodock Vina and other software are used to calculate the molecular docking and binding energy between compounds and key targets. Finally, the therapeutic effect of the new prescription of Fructus schisandrae chinensis S·(Core) on diabetic mice was evaluated by biological experiments.Results: The study employed a data mining S·(Core) was obtained. Using network pharmacology method, mainly containing target prediction, network construction, functional enrichment analysis, and molecular docking to systematically research the mechanisms of S·(Core) in treating diabetes. The putative targets of S·(Core) that treat diabetes mainly involved AKT1, GAPDH, IL-6, MAPK3, VEGFA and other targets. The functional enrichment analysis suggested that the produced therapeutic effect of S·(Core) against diabetes is mediated by synergistical regulation of several biological pathways, AGE-RAGE signaling pathway in diabetic complications , Insulin resistance, HIF-1 and Insulin signaling pathway. The results of molecular docking showed that the core chemical components of S·core had good affinity with the key targets of diabetes. In addition,We confirmed that S·Core can improve glucose and lipid metabolism in diabetic mice. Enhanced islet β Quantity and quality of cells. Reduce the inflammatory response in the body. Liver protection.Conclusion: This study explored the mechanism of action of S·(Core) in diabetes by multi-component and multi-target multi pathways, which could provide a theoretical basis for the development and clinical application of S·(Core).
A Survey on Power Aware Routing in Manet

Adhoc network is a network without centralized administration in which different users can communicate and ex-change information. Mobile Ad-hoc Network (MANET) is a self configuring self organizing collection of mobile ad-hoc nodes with no fixed infrastructure. The node is free to move and the network topology changes rapidly. As the nodes in Mobile Ad hoc Network (MANET) have limited battery so power is always an issue in MANET. Power failure of node in MANET not only affects the node itself but also affects its ability to forward the data packet to the next hop and thus reduce the lifetime of network. In order to maximize the lifetime of the network energy consumption of each node must be controlled. This paper survey different energy related metrics used in Routing and some power aware routing protocols