Miracle-dz/UniFAR-FTUs huggingface dataset:
CATECHOLASE ACTIVITY AND SUBSTITUENT EFFECT OF NEW HOMOLEPTIC COPPER(II) CHALCONE COMPLEXES

<p>Three new neutral complexes of copper(II) containing chalcone ligands derived from 2'-hydoxyacetophenone and 4-substituted benzaldehydes were synthesized. Complexes were prepared by solution synthesis and characterized by spectroscopy. The catalytic activity of complexes was examined in the reaction of 3,5-di-tertbutylcatehcol (DTBC) oxidation. The kinetics of DTBC catalytic oxidation by copper(II) complexes (1 &ndash; 3) was investigated spectrophotometrically under pseudo-first-order conditions. Catalytic parameters, the maximum reaction rate (vmax), Michaelis-Menten constant (KM), catalytic efficiency, catalytic reaction rate constant (kcat), turnover number (TON), and turnover frequencies (TOF) for complexes 1 &ndash; 3 in DTBC oxidation were collected. The studied complexes 1 and 2 were found to have moderate catalytic activity, while complex 3 does not show catalytic properties. </p>
Gender differences in geriatric depressive symptoms in urban China: the role of ADL and sensory and communication abilities

Objectives ADL and Sensory and Communication Abilities are important indicators of the quality of life of the elderly which are significant determinants of health, particularly in developing countries. The present cross-sectional study investigated effect of ADL and Sensory and Communication Abilities on depressive symptoms, as well as the the role of gender in these effects. Design This is a cross-sectional study. Setting A nationally representative cross-sectional survey among the Chinese population aged 60 years and over. Participants A total of 163296 females and 148724 males aged 65 and over in 2019 in urban China. Outcome measures Prevalence, risk factors and gender differences in geriatric depressive symptoms among urban elderly. Results Approximately 95.69% of the participants had depressive symptoms according to the CESD-10, with no statistically significant gender difference of 52.15% in females and 47.85% in males. Logistic regression findings suggest that geriatric depressive symptoms are significantly associated with the lack of eldercare (OR=2.427, female; OR=1.426, male), living alone(OR= 1.430, female; OR= 1.179, male), ADL dysfunction (OR=1.528, female; OR=1.246, male), and impaired sensory and communication ability (OR=1.338, female; OR=1.185, male) among both female and male participants. Remarkably, geriatric depressive symptoms are only significantly associated with age (≥75, OR = 1.327), marital status (unmarried, OR=1.598), the number of children (no children, OR=2.271), and the living arrangement (living alone, OR= 1.430) among female participants. Conclusion Significant gender differences in these associations were found for living alone, ADL dysfunction and impaired sensory and communication ability. Moreover, the study emphasized that the gender difference exists in terms of geriatric depression in urban China. Females are more likely to experience depressive than males with the same circumstances.
Detection of Underground Geological Structure by Radio-wave Laneway Penetration Technology

Hidden geological anomalies such as roof water and fault of working face will affect the mining progress and even induce coal and rock dynamic disaster. Therefore, it is necessary to use radio-wave laneway penetration meter for detection in the process of coal mining. The geological structure existing in the F6226 working face has been basically verified by this technology, which provides technical basis and support for geological work such as drilling. Through the study of the application effect of F6226 working face laneway penetration technology, and comparison with the real data revealed in the actual drilling and mining, the delineated abnormal areas in the laneway penetration results show that the abnormal areas of the 3D seismic data are verified and a collapse column is modified. The application of laneway penetration technology in mine geology improves the safety of coal mine production.
Optimizing Childhood Obesity Management: The Role of Edmonton Obesity Staging System in Personalized Care Pathways

Childhood obesity, affecting 29% of 7–9-year-olds across 33 European countries, is a significant public health challenge. Its persistence into adulthood poses grave health risks influenced by genetic, environmental, and socio-economic factors. Belgium introduced a new care pathway in December 2023, based on the Edmonton Obesity Staging System for Pediatrics (EOSS-P), addressing four health domains and staging obesity severity. This pathway operates across three levels: primary care physicians, Paediatric Multidisciplinary Obesity Management Centres (PMOCs), and Centers of Expertise for Paediatric Obesity Management (CEPOs). Each stage of EOSS-P demands tailored interventions. Early stages involve dietary interventions, physical activity promotion, and behavior modifications. As obesity severity progresses, treatments intensify, encompassing psychological support, anti-obesity medications, and, in some cases, bariatric surgery. Throughout these stages, the involvement of multidisciplinary teams is crucial, emphasizing family-based approaches and continuous monitoring. This article provides detailed guidelines for healthcare professionals, delineating interventions and recommendations tailored to each EOSS-P stage. It emphasizes a holistic approach that extends beyond BMI-based diagnosis, promoting personalized care and prompt escalations between care levels, thereby ensuring optimal management of childhood obesity. This comprehensive framework aims to address the complexities of childhood obesity, emphasizing the importance of timely and targeted interventions for better health outcomes.
Elevated mercury measured in snow and frost flowers near Arctic sea ice leads

Elevated mercury concentrations have been reported in arctic coastal snow far from emission sources. The mercury is deposited during mercury depletion events (MDEs), a set of photochemical atmospheric reactions involving reactive halogens. The highest mercury concentrations are clustered near the coast, leading to speculation that sea ice or sea ice leads play a role in MDEs. The nature of this connection is not fully understood. We report mercury concentrations up to 820 ng/L in snow and frost flowers along sea ice leads near Barrow, Alaska. These concentrations are nine times higher than values from nearby coastal snow and are almost half of the mercury maximum contaminant level in United States drinking water. The high values were found only near leads that had convective plumes above open water suggesting that the same processes that produce a supersaturated environment for water vapor near sea ice leads may be instrumental in mercury deposition.
Vertical Profiles of Ice Cloud Microphysical Properties and Their Impacts on Cloud Retrieval Using Thermal Infrared Measurements

Despite the vertically inhomogeneous (VIH) structure of ice clouds, current passive remote sensing methods assume plane‐parallel homogeneous (PPH) layers, which can lead to retrieval errors. An adequate VIH cloud model is required to improve retrieval performance. In this study, CloudSat and CALIPSO satellite measurements in a 1‐year period were analyzed to model cloud vertical inhomogeneity, and its impacts on cloud retrieval were assessed using thermal infrared (TIR) measurements. The satellite measurements revealed that the peak ice water content (IWC) located around the cloud vertical midpoint moved toward the cloud base as the ice water path (IWP) increased in clouds with small IWP values; thicker clouds exhibited a gradual shift in IWC peak location toward the cloud top as IWP increased. The vertical profiles of both the cloud‐particle effective radius (CER) and a proxy of cloud‐particle number concentration showed close associations with the vertical IWC profile. An empirical model linking cloud geometrical thickness to columnar optical properties (IWP and column‐mean CER) as a function of cloud‐top temperature was also proposed. Compared with a model assuming PPH clouds, the VIH cloud model improved retrieval performance by reducing the retrieval error of the TIR‐based passive remote sensing algorithm. Further, by increasing the retrieved values of cloud‐top height noticeably for high‐level clouds and column‐mean CER considerably, with minimal effects on cloud optical thickness retrieval, the VIH cloud model yielded results that were in better agreement with radar/lidar ice cloud products than those obtained under the assumption of PPH cloud layers.
Compartmentalization of class 1 integrons and IncP-1 plasmids in the Orne river (France), an aquatic ecosystem impacted by urban and industrial anthropogenic pressures

Les elements genetiques mobiles (EGM) sont des structures genetiques frequemment associees a la dissemination de genes de resistance aux antibiotiques (GRA). Dans ce travail, nous avons utilise deux EGM comme « proxies », les integrons de classe 1 et les plasmides IncP-1, afin de mieux comprendre (i) le devenir possible des GRA une fois relargues dans un ecosysteme fluvial (l’Orne, France), ainsi que (ii) l’effet des pressions anthropiques sur leur persistance. A partir d'analyses de l'eau des rivieres, nous avons pu montrer que les deux EGM ne se comportaient pas de la meme maniere. L'entree des integrons de classe 1 dans le systeme fluvial semblait etre diffuse plutot que ponctuelle, tandis que l'abondance du plasmide IncP-1 est relativement stable le long de la section de la riviere etudiee (23 km), indiquant ainsi une origine plutot indigene. Les intrants anthropiques tels que les stations d’epuration des eaux usees ne semblent pas affecter l’abondance des EGM en raison d’un niveau trop eleve de dilution des effluents. Par ailleurs, il est interessant de noter que les bacteries porteuses d’EGM semblaient etre enrichies sur les matieres en suspension, susceptibles de servir de vehicule pour amener des communautes de bacteries plus riches en EGM vers les sediments. L'analyse de deux carottes de sediment indique clairement que seules les couches superieures presentent un niveau eleve de bacteries porteuses d’EGM. Ces abondances diminuent dans les couches plus profondes ou seules des zones ponctuelles presentent des microreservoirs avec des abondances d’EGM plus elevees. Pour une carotte sedimentaire au moins, nous avons pu montrer que l'abondance relative d’EGM correle negativement la presence de polluants tel que le plomb ou certains HAP
Bone Health Impairment in Patients with Hemoglobinopathies: From Biological Bases to New Possible Therapeutic Strategies

Hemoglobinopathies are monogenic disorders affecting hemoglobin synthesis. Thalassemia and sickle cell disease (SCD) are considered the two major hemoglobinopathies. Thalassemia is a genetic disorder and one of the major hemoglobinopathies determined by an impairment of globin chain production, which causes an alteration of erythropoiesis, an improvement in hemolysis, and an alteration of iron homoeostasis. In SCD, the mutations are on the β-globin chain of hemoglobin which results in a substitution of glutamic acid by valine with consequent formation of Hemoglobin S (HbS). Several factors are involved in bone metabolism alteration in patients with hemoglobinopathies, among them hormonal deficiency, bone marrow hyperplasia, iron overload, inflammation, and increased bone turnover. Bone metabolism is the result of balance maintenance between bone deposition and bone resorption, by osteoblasts (OBs) and osteoclasts (OCs). An impairment of this balance is responsible for the onset of bone diseases, such as osteoporosis (OP). Therefore, here we will discuss the alteration of bone metabolism in patients with hemoglobinopathies and the possible therapeutic strategies to contain and/or counteract bone health impairment in these patients, taking into consideration not only the pharmacological treatments already used in the clinical armamentarium, but also the new possible therapeutic strategies.
Financial Performance of Dairy Cooveratives in West Java-Indonesia During the Covid-19 Pandemic and Foot-and-Mouth Disease Outbreak

Dairy cooperatives play an important role to collect milk production from dairy farmers, distribution of milk to the milk processing industry, concentrate supply services, credit guarantees, artificial insemination and animal health services, savings and loan services, and various other services carried out by cooperatives. This condition causes the dependence of dairy farmers on cooperatives to be quite high. External factors can influence cooperative resilience, such as the Covid-19 pandemic and Foot-and-Mouth Disease (FMD). Therefore, the purpose of this study was to analyze the performance of cooperative milk production, and to the financial performance of cooperatives in the post-pandem Covid-19 period and during FMD. The method used in this study was a survey method to KPBS Pangalengan which represents large cooperatives, KSU Tandangsari which represents medium-sized cooperatives, and KPS Bogor which represents small cooperatives. The analysis method used standard cooperative performance methods through regulations of the Deputy for Supervision of the Ministry of Cooperatives and Small and Medium Enterprises (KUKM) of the Republic of Indonesia Number 06/Per/Dep.6/IV/2016 and key perfomance index to assess the financial performance of cooperatives. The results of the study showed that the performance of cooperative milk production decreased by 19.45% during the Covid-19 pandemic to the FMD as a result of the dairy cow mortality rate of 20.14%. The financial performance of dairy cow cooperatives was in the adequate category, both during the Covid-19 pandemic and FMD, but there was a decline in the ratio in all aspects of financial performance during the FMD. Thus, the performance of milk production and the financial performance of dairy cooperatives was better during the Covid-19 pandemic than during the FMD period. Therefore, strengthening milk production by providing new dairy cows and strengthening finances is very important
CNN-based Encoder-Decoder for Frame Interpolation

The ability to accurately interpolate intermediate frames with two given frames has many applications, including video compression and frame rate up-sampling. Traditional video processing techniques has always dominated the field and tackles the challenge with optical flow estimation. However, optical flow estimation has a trade-off between speed and accuracy and estimating optical flow robustly is difficult in real time. The application of Deep Learning have been introduced to Frame Interpolation recently. Our final model extends an CNN-based encoderdecoder approach to Frame Interpolation. While the performance of our model is sub-par to the current state-of-the-art techniques, it outperforms the baseline of Linear Interpolation and can be run in real time.
Health Seeking Behaviour of Caregivers of Under-Fives during Episodes of Acute Respiratory Infection in an Urban Community in Edo State

Health Seeking Behaviour of Caregivers of Under-Fives during Episodes of Acute Respiratory Infection in an Urban Community in Edo State 1, 2 Osarogiagbon, WO Isara, AR WHO and UNICEF came to a conclusion that early recognition of symptoms and signs of ARI at home and reporting quickly in a health centre was key to a favourable outcome 1-4 during episodes of ARI. The main thrust of this is the 3-point approach adopted by WHO and UNICEF in the reduction of ARI 4,5 mortality. As part of this 3-prongs approach is increasing access to quality care achieved through community-based care. Under this approach community health workers incollaboration with caregivers are trained to assess sick children for signs of ARI and select appropriate treatment and go ahead to administer the appropriate dosage of a n t i b i o t i c s w e r e a p p r o p r i a t e . 1 Department of Child Health, University of Benin Teaching Hospital, Benin City, Edo State-Nigeria. 2 Department of Community Health, University of Benin Teaching Hospital, Benin City, Edo StateNigeria. Dr Osarogiagbon WO, Department of Child Health, University of Benin Teaching Hospital, Benin City, Edo State-Nigeria. Contact number:+234 802 339 6904 eMail:divinewilbel@yahoo.com Correspondence to: ORIGINAL ARTICLE Borno Medical Journal Vol. 14 Issue 2 Page 197 July December 2017 This work is licensed under a Creative Commons Attribution 4.0 International License
Psychological Distress Associated with Enforced Hospital Isolation Due to COVID-19 during the “Flatten the Curve” Phase in Morocco: A Single-Center Cross-Sectional Study

(1) Background: although much research has highlighted the mental health challenges faced by patients in hospital isolation during the COVID-19 pandemic, data from low–middle-income countries, including Morocco, are lacking. The main objective of this study was to assess the psychological distress of patients undergoing enforced hospital isolation during the initial phase of the COVID-19 pandemic in Morocco. (2) Methods: we conducted a cross-sectional study between 1 April and 1 May 2020, among patients hospitalized in isolation for suspected or confirmed COVID-19 at the Ibn Sina University Hospital of Rabat, Morocco. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS). Binary logistic regression was performed to identify variables associated with anxiety and depression, with a cutoff of ≥8 used for both scales to create dichotomous variables. (3) Results: among 200 patients, 42.5% and 43% scored above the cut-off points for anxiety and depression, respectively. Multiple logistic regression identified female gender, a higher education level, a longer duration of isolation, and a poor understanding of the reasons for isolation as significant factors associated with anxiety. Conversely, female gender, chronic disease, a longer duration of isolation, and a poor understanding of the reasons for isolation were factors significantly associated with depression. (4) Conclusions: our study underscores high rates of anxiety and depression among patients forced into hospital isolation during the initial phase of COVID-19 in Morocco. We identified several factors associated with patients experiencing psychological distress that may inform future discussions on mental health and psychiatric crisis management.
Landfalling tropical cyclones in the Eastern Pacific. Part II: WRF simulations of John and Paul (2006)

Three tropical cyclones that developed during the 2006 season over the eastern Pacific ocean, made landfall in northwestern Mexico. John affected Baja California and Lane and Paul brought intense precipitation to the mainland. The observational characteristics of these events are described in a companion study at this conference (Farfan et al, 2008) and, here, we focus on numerical simulations performed using the Weather Research and Forecasting (WRF) model.
Prediction of Ki-67 expression in bladder cancer based on CT radiomics nomogram

Objectives This study aimed to create and validate a radiomics nomogram for non-invasive preoperative Ki-67 expression level prediction in patients with bladder cancer (BCa) using contrast-enhanced CT radiomics features. Methods A retrospective analysis of 135 patients was conducted, 79 of whom had high levels of Ki-67 expression and 56 of whom had low levels. For the dimensionality reduction analysis, the best features were chosen using the least absolute shrinkage selection operator and one-way analysis of variance. Then, a radiomics nomogram was created using multiple logistic regression analysis based on radiomics features and clinical independent risk factors. The performance of the model was assessed using the Akaike information criterion (AIC) value, the area under the curve (AUC) value, accuracy, sensitivity, and specificity. The clinical usefulness of the model was assessed using decision curve analysis (DCA). Results Finally, to establish a radiomics nomogram, the best 5 features were chosen and integrated with the independent clinical risk factors (T stage) and Rad-score. This radiomics nomogram demonstrated significant correction and discriminating performance in both the training and validation sets, with an AUC of 0.836 and 0.887, respectively. This radiomics nomogram had the lowest AIC value (AIC = 103.16), which was considered to be the best model. When compared to clinical factor model and radiomics signature, DCA demonstrated the more value of the radiomics nomogram. Conclusion Enhanced CT-based radiomics nomogram can better predict Ki-67 expression in BCa patients and can be used for prognosis assessment and clinical decision making.
Global, regional and national burdens of reproduction-related congenital birth defects, 1990–2019

Background Reproduction-related congenital birth defects (RCBDs), including Klinefelter syndrome (KS), Turner syndrome (TS), and urogenital congenital anomalies (UCA), can lead to severe physical and psychosocial disorders. The global impact of RCBDs on children and adults is unknown, which limits high-quality development of populations and increases in life expectancy per capita. Methods Annual incidence rates, prevalence rates (PR), and disability-adjusted life year (DALY) rates were collected for KS, TS, and UCA for 204 countries and territories, including at birth, for children younger than 1 year, and age-standardized (AS) for all ages. Linear regression was used to calculate their estimated annual percentage changes (EAPCs). Finally, the relationships between EAPCs of each indicator and sociodemographic index (SDI) was investigated using Pearson correlation analysis. Results Globally, the age-standardized prevalence rate (ASPR) trend is decreasing in KS and TS and increasing in UCA. The DALY rates for children younger than 1 year were on a downward trend in KS and UCA, while they were still rising for TS. The AS-DALY rates were all on a downward trend in KS, TS, and UCA. The DALY rates of KS, TS and UCA were found higher in high-income countries in North America. In addition, the burdens of TS and UCA went down with increasing SDI, whereas the burden of KS increased with increasing SDI. Conclusion The global burdens of RCBDs have decreased since 1990. This finding can help policymakers implement cost-effective interventions to reduce the burdens of RCBDs.
Mechanistic Plug-And-Play Models for Understanding the Impact of Control and Climate on Seasonal Dengue Dynamics in Iquitos, Peru

Dengue virus is a mosquito-borne multi-serotype disease whose dynamics are not precisely understood despite half of the world’s human population being at risk of infection. A recent dataset of dengue case reports from an isolated Amazonian city— Iquitos, Peru—provides a unique opportunity to assess dengue dynamics in a simplified setting. Ten years of clinical surveillance data reveal a specific pattern: two novel serotypes, in turn, invaded and exclusively dominated incidence over several seasonal cycles, despite limited intra-annual variation in climate conditions. Together with mechanistic mathematical models, these data can provide an improved understanding of the nonlinear interactions between the environmental and biological factors underlying dengue transmission as well as aid in the prediction of future epidemics. To examine the drivers of dengue in Iquitos we develop several stochastic discretetime models and use likelihood-based plug-and-play inference techniques to explore potential factors that may explain the seasonal transmission pattern. By including climate-informed variables and accounting for known vector control measures in our model, we illustrate scenarios that can replicate the observed data and uncover the contribution of previously overlooked factors, such as the role of disease importation from human population migration. We discuss the implications of these results for understanding dengue dynamics in other endemic settings.