Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of SclR on metabolite production in Aspergillus oryzae

Aspergillus oryzae, an industrially important fungus utilized for the traditional fermentative manufacturing, produces diverse metabolites and enzymes during fermentation. In our previous study, we have ever identified and characterized a basic helix-loop-helix (bHLH) transcription factor, SclR, and found that the transcription factor is importantly involved in the conidiation, sclerotial formation, and hyphal morphology in A. oryzae. In this study, we further analyzed the effect of SclR on metabolites production in A. oryzae. The control strain and ∆sclR strain were cultivated in dextrin-polypeptone-yeast extract (DPY) liquid medium at 30 °C for 3 days and metabolites were extracted from strains. Liquid chromatography–mass spectrometry (LC-MS) analysis result showed that a total of 1,855 precursor molecules were obtained in the positive ion mode and 2,475 precursor molecules were obtained in the negative ion mode. Comparative analysis of the metabolome indicated that 259 were differentially expressed metabolites. Among of them, 161 metabolites were increased by 1.5-fold, and 98 metabolites were decreased by 1.5-fold in an sclR gene deletion strain compared to the control. Further identification of differentially expressed metabolites revealed that the production level of some organic acids, amino acids, and sugar alcohols were markedly changed in ∆sclR strain relative to control strain. Especially, some organic acids were identified to be intermediates in the citric acid cycle, which is a key metabolic pathway that connects carbohydrate, fat, and protein metabolism. The result also implied that the SclR is potentially involved in energy metabolism.
Indications for Digital Monitoring of Patients With Multiple Nevi: Recommendations from the International Dermoscopy Society

Introduction In patients with multiple nevi, sequential imaging using total body skin photography (TBSP) coupled with digital dermoscopy (DD) documentation reduces unnecessary excisions and improves the early detection of melanoma. Correct patient selection is essential for optimizing the efficacy of this diagnostic approach. Objectives The purpose of the study was to identify, via expert consensus, the best indications for TBSP and DD follow-up. Methods This study was performed on behalf of the International Dermoscopy Society (IDS). We attained consensus by using an e-Delphi methodology. The panel of participants included international experts in dermoscopy. In each Delphi round, experts were asked to select from a list of indications for TBSP and DD. Results Expert consensus was attained after 3 rounds of Delphi. Participants considered a total nevus count of 60 or more nevi or the presence of a CDKN2A mutation sufficient to refer the patient for digital monitoring. Patients with more than 40 nevi were only considered an indication in case of personal history of melanoma or red hair and/or a MC1R mutation or history of organ transplantation. Conclusions Our recommendations support clinicians in choosing appropriate follow-up regimens for patients with multiple nevi and in applying the time-consuming procedure of sequential imaging more efficiently. Further studies and real-life data are needed to confirm the usefulness of this list of indications in clinical practice.
Collective excitations of trapped Fermi or Bose gases

A method is developed to calculate all excitations of trapped gases using hydrodynamics at zero temperature for any equation of state $\ensuremath{\mu}=\ensuremath{\mu}(n)$ and for any trapping potential. It is shown that a natural scalar product can be defined for the mode functions, by which the wave operator is Hermitian and the mode functions are orthogonal. It is also shown that the Kohn modes are exact for harmonic trapping in the hydrodynamic theory. Excitations for fermions are calculated in the Bardeen-Cooper-Schrieffer\char21{}Bose-Einstein condensation transition region using the equation of state of the mean-field Leggett model for isotropic harmonic trap potential.
qu an tph ] 1 4 D ec 2 01 6 Maximal coherence in generic basis

Yao Yao,1, 2, ∗ G. H. Dong,3 Li Ge,4 Mo Li,1, 2, † and C. P. Sun3, 5 1Microsystems and Terahertz Research Center, China Academy of Engineering Physics, Chengdu Sichuan 610200, China 2Institute of Electronic Engineering, China Academy of Engineering Physics, Mianyang Sichuan 621999, China 3Beijing Computational Science Research Center, Beijing, 100094, China 4School of Science, Hangzhou Dianzi University, Hangzhou Zhejiang 310018, China 5Synergetic Innovation Center of Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, Anhui 230026, China (Dated: July 30, 2018)
Neoadjuvant Chemotherapy Followed by Radiofrequency Ablation May Be a New Treatment Modality for Colorectal Liver Metastasis: A Propensity Score Matching Comparative Study

Simple Summary Whether neoadjuvant chemotherapy followed by radiofrequency ablation, a new therapeutic modality, may achieve a similar prognosis to neoadjuvant chemotherapy followed by hepatectomy has yet to be explored. A total of 190 colorectal liver metastases patients met the inclusion criteria. The 3-year progression-free survival in the neoadjuvant chemotherapy followed by liver resection and neoadjuvant chemotherapy followed by the radiofrequency ablation groups was 38.8% vs. 55.3%. Compared with the neoadjuvant chemotherapy followed by hepatectomy, neoadjuvant chemotherapy followed by radiofrequency ablation has the characteristics of rapid recovery, lower progression rate, and fewer complications. Abstract Background: Most colorectal liver metastases (CRLM) are not candidates for liver resection. Radiofrequency ablation (RFA) plays a key role in selected CRLM patients. Neoadjuvant chemotherapy (NAC) followed by liver resection has been widely used for resectable CRLM. Whether NAC followed by radiofrequency ablation (RFA) can achieve a similar prognosis to NAC followed by hepatectomy remains is unclear. The present study aimed to provide a new treatment modality for CRLM patients. Methods: This comparative retrospective research selected CRLM patients from 2009 to 2022. They were divided into NAC + RFA group and NAC + hepatectomy group. The propensity score matching (PSM) was used to reduce bias. We used multivariate cox proportional hazards regression analysis to explore independent factors affecting prognosis. The primary study endpoint was the difference in the progression-free survival (PFS) between the two groups. Results: A total of 190 locally curable CRLM patients were in line with the inclusion criteria. A slight bias was detected in the comparison of basic clinical characteristics between the two groups. RFA showed a significant advantage in the length of hospital stay (median; 2 days vs. 7 days; p < 0.001). The 1- and 3-year PFS in the liver resection and the RFA groups was 57.4% vs. 86.9% (p < 0.001) and 38.8% vs. 55.3% (p = 0.035), respectively. The 1-year and 3-year OS in the liver resection and RFA groups was 100% vs. 96.7% (p = 0.191) and 73.8% vs. 73.6% (p = 0.660), respectively. Conclusions: NAC followed by RFA has rapid postoperative recovery, fewer complications, and better prognosis.
Impact of Calcium and Nitrogen Addition on Bioethanol Production by S. cerevisiae Fermentation from Date By-Products: Physicochemical Characterization and Technical Design

Given crude oil prices and their environmental impacts, the use of sustainable renewable alternative energies such as biofuels is rapidly progressing in numerous countries. Among biofuels, bioethanol is a renewable and clean fuel that can be obtained from the fermentation of several raw agricultural materials, including date fruit. However, the low product yield, mainly due to the low-grade nutrient content, limits its use as a promising alternative biofuel. This current study investigated bioethanol production from date by-products in Saudi Arabia and examined the impact of calcium and nitrogen sources added at different concentrations (0 to 1 g/L) on the productivity and ethanol concentration using Saccharomyces cerevisiae. Yeast extracts and ammonium chloride (NH4Cl) were tested as nitrogen sources for bioethanol fermentation from date juice. Calcium chloride (CaCl2) and calcium carbonate (CaCO3) were evaluated as calcium sources for the same purpose mentioned above. The results showed that both calcium and nitrogen sources improved ethanol production efficiencies. The addition of calcium sources such as CaCl2 at 0.4 g/L resulted in maximum ethanol concentration (41.5 ± 0.85 g/L) and the highest productivity of 0.511 g/L/h. Thus, an increase of 31.3% compared to the control sample was acquired. Ammonium chloride was found to be the best nitrogen supplement among them. Indeed, supplementing the fermentation medium with 1 g/L NH4Cl gave an optimal ethanol concentration and productivity, reaching more than 65 g/L and 0.83 g/L/h, respectively. This is an increase of 106.6%. The functional group of ethanol (C2H5OH) for all the elaborated samples was confirmed by Fourier-transform infrared spectroscopy (FTIR) and NMR analyses. Moreover, the results confirmed the high quality and purity of the bioethanol products. Thus, the “Khodhari” date variety of low market value is a privileged substrate for industrial bioethanol production. For this reason, a proposed flow diagram of a designed plant for bioethanol industrialization is provided and detailed.
ASASSN-15nx: A Luminous Type II Supernova with a “Perfect” Linear Decline

We report a luminous Type II supernova, ASASSN-15nx, with a peak luminosity of mag that is between those of typical core-collapse supernovae and super-luminous supernovae. The post-peak optical light curves show a long, linear decline with a steep slope of 2.5 mag (100 day)−1 (i.e., an exponential decline in flux) through the end of observations at phase . In contrast, the light curves of hydrogen-rich supernovae (SNe II-P/L) always show breaks in their light curves at phase ∼100 day, before settling onto 56Co radioactive decay tails with a decline rate of about 1 mag (100 day)−1. The spectra of ASASSN-15nx do not exhibit the narrow emission-line features characteristic of Type IIn SNe, which can have a wide variety of light-curve shapes usually attributed to strong interactions with a dense circumstellar medium (CSM). ASASSN-15nx has a number of spectroscopic peculiarities, including a relatively weak and triangular-shaped Hα emission profile with no absorption component. The physical origin of these peculiarities is unclear, but the long and linear post-peak light curve without a break suggests a single dominant powering mechanism. Decay of a large amount of (MNi = 1.6 ± 0.2 ) can power the light curve of ASASSN-15nx, and the steep light-curve slope requires substantial γ-ray escape from the ejecta, which is possible given a low-mass hydrogen envelope for the progenitor. Another possibility is strong CSM interactions powering the light curve, but the CSM needs to be sculpted to produce the unique light-curve shape and avoid producing SN IIn-like narrow emission lines.
On the Baryometric Status of 3He

Recent observations by Bania et al. measure 3He versus oxygen in Galactic H II regions, finding that 3He/H is within a factor of 2 of the solar abundance for [O/H] ≳ -0.6. These results are consistent with a flat behavior in this metallicity range, tempting one to deduce from these observations a primordial value for the 3He abundance, which could join D and 7Li as an indicator of the cosmic baryon density. However, using the same data, we show that it is not possible to obtain a strong constraint on the baryon density range. This is due to (1) the intrinsically weak sensitivity of the primordial 3He abundance to the baryon density, (2) the limited range in metallicity of the sample, (3) the intrinsic scatter in the data, and (4) our limited understanding of the chemical and stellar evolution of this isotope. Consequently, the 3He observations correspond to an extended range of baryon-to-photon ratio, η = (2.2-6.5) × 10-10, which diminishes the role of 3He as a precision baryometer. On the other hand, once the baryon-to-photon ratio is determined by the cosmic microwave background, D/H, or 7Li/H, the primordial value of 3He/H can be inferred. Henceforth, new observations of Galactic 3He can in principle greatly improve our understanding of stellar and/or chemical evolution and reconcile the observations of the H II regions and those of the planetary nebulae.
LOW-QUALITY FLAX STRAW BIOMASS HARVESTING FOR SUBSEQUENT USE AS FUEL: A REVIEW

Unfavorable conditions for flax growing, harvesting and dew-retting are the reason for the low-quality flax biomass production. This biomass cannot be processed for fiber or other purposes. Therefore, flax straws are burned in the fields or are used as fertilizer by plowing into the soil, which are not good solutions for the environment and subsequent cultivation operations. The limit values of quality properties of fibre flax stem, flax straw and retted straw for their processing are summarized, which can be used to determine the suitability of flax straw biomass for processing or burning. Low-quality flax biomass is inexpensive, ecofriendly and renewable, it can be used as solid fuel for heating greenhouses or buildings located near the field where the flax is grown. Various techniques of fibre flax and oilseed flax harvesting are presented in the article. The technique of low-quality flax harvesting is recommended, which include flax pulling out or flax cutting, flax threshing, flax straw windrow forming, flax straw natural drying on the field in natural way, flax bale forming, flax bale transporting, flax bale burning. This harvesting technology can be used for low-quality fibre flax and oilseed flax. Flax straw biomass can be baled into three bale types: small rectangular bales, big round bales, and big square bales The main requirements for fuel flax biomass bales are recommended. The boiler for burning flax straw bales must be chosen taking into account the shape and size of the bales. For the efficient operation of boilers, it is necessary to take into account the recommended values ​​of bale bulk density and moisture content of flax biomass.
The Development of a Built-In Shoe Plantar Pressure Measurement System for Children

There is a rapid increase in plantar pressure from the infant to toddler stage, yet little is known about the reasons for this change. More information about plantar pressure distribution can help clinicians identify early-stage foot-related diseases that may occur during transitions from childhood to adulthood. This information also helps designers create shoes that adapt to different needs. This research describes the development of a low-cost, built-in shoe plantar pressure measurement system that determines foot pressure distribution in toddlers. The study aimed to improve and provide data on pressure distribution during foot growth. This was accomplished by implementing a plantar pressure capacitive measurement system within shoes. The capacitive sensors were laminated using a copper tape sheet on plastic backing with adhesive, elastomer layers, and a combination of conductive and non-conductive fabrics. Constructed sensors were characterized using compression tests with repeated loads. Results demonstrated that the sensors exhibited rate-independent hysteresis in the estimation of pressure. This enabled a calibration model to be developed. The system can mimic more expensive plantar pressure measurement systems at lower fidelity. This emerging technology could be utilized to aid clinicians, researchers, and footwear designers interested in how pressure distribution changes from infants to toddlers.
Suitable domains to define fractional integrals of Weyl via fractional powers of operators

We present a new method to study the classical fractional integrals of Weyl. This new approach basically consists in considering these operators in the largest space where they make sense. In particular, we construct a theory of fractional integrals of Weyl by studying these operators in an appropriate Fréchet space. This is a function space which contains the L(R)-spaces, and it appears in a natural way if we wish to identify these fractional operators with fractional powers of a suitable non-negative operator. This identification allows us to give a unified view of the theory and provides some elegant proofs of some well-known results on the fractional integrals of Weyl.
Fuzzy Q-Learning interaction controller design for collaborative robot

Background: In physical human-robot interaction (pHRI), admittance control is widely used. The most critical thing in admittance control is the configuration of admittance parameters, but a constant admittance value can not meet the needs of interactive indicators smoothness especially. Variable admittance control is a method to overcome this limitation by adjusting the admittance value in real time. This paper proposes a fuzzy Q-learning (FQL) variable admittance control system, which integrates the fuzzy system (FIS) and reinforcement learning method Q-learning. Methods: FIS is used to turn a continuous input state into fuzzy set and Q-learning is used to train the premise strength of fuzzy rules to get the optimal policy of variable admittance value. To verify the performance of this method, an experiment was performed using an AUBO i5 robot. Training trajectory is point-to-point (PTP) trajectory, several interaction variables before and after training by the algorithm are compared to show the validity of algorithm. Results: Experimental results show that the reward converges to a smaller value in about 25 episodes, and the reward of the last five episodes reduces by 68%. The motion trajectory after algorithm training is closer to the ideal min-jerk trajectory and the deviation and mean value of interaction force become smaller. Conclusions: The proposed FQL method can converge in a few episodes and can improve the performance of pHRI by minimizing the jerk based cost function
The Number Density of Old Passively Evolving Galaxies at z = 1 in the Subaru/XMM-Newton Deep Survey Field

We obtained the number counts and the rest-frame B-band luminosity function of color-selected old passively evolving galaxies (OPEGs) at z = 1 with very high statistical accuracy using a large and homogeneous sample of about 4000 such objects with z′ < 25 detected in an area of 1.03 deg2 in the Subaru/XMM-Newton Deep Survey (SXDS) field. Our selection criteria are defined on the i′ - z′ and R - z′ color-magnitude plane so that OPEGs at z = 0.9-1.1 with formation redshift zf = 2-10 are properly sampled with minimum contamination by other populations. The limiting magnitude corresponds to the luminosity of galaxies with M* + 3 at z = 0. We made pilot redshift observations for 99 OPEG candidates with 19 < z′ < 22 and found that at least 78% (73 of 93) of the entire sample, or 95% (73 of 77) of those whose redshifts were obtained, indeed lie between z = 0.87 and 1.12, and most of their spectra show a continuum break and strong Ca H and K lines, indicating that these objects are indeed dominated by the old stellar populations. The relationship between the observed redshift and the color closely follows the models used in defining the selection criteria in a consistent manner. We found that the surface number density of OPEGs varies by 10%-30% of the average of the entire sample from field to field even at a 30' scale and that the poorest field, SXDS-South, has only 65% of that of the richest one, SXDS-East. We then compared our results with the luminosity functions of the color- or morphologically selected early-type galaxies at z = 0, taking the evolutionary factor into account, and found that the number density of old passive galaxies with ~M* magnitude at z ~ 1 averaged over the SXDS area is 40%-60% that of equivalently red galaxies and 60%-85% that of morphologically selected E/S0 galaxies at z = 0 depending on their luminosity evolution. It is revealed that more than half, but not all, of the present-day early-type galaxies had already evolved into quiescent passive galaxies at z = 1.
Climate Change Projections over East Asia with BCC_CSM1.1 Climate Model under RCP Scenarios

We study climate change projections over East Asia under various representative concentration pathway (RCP) scenarios using simulations performed with the Beijing Climate Center Climate System Model version 1.1 (BCC_ CSM1.1) for the Coupled Model Intercomparison Project phase 5 (CMIP5). Under all RCPs (including RCP2.6, RCP4.5, RCP6.0, and RCP8.5), East Asian climate is found to be warmer and wetter in the 21st century than the present climatology (19862005). For 20802099, East Asian mean surface air temperature (precipitation) is higher than that for the present climatology by 0.98° C (4.4%) under RCP2.6, 1.89° C (7.7%) under RCP4.5, 2.47° C (7.1%) under RCP6.0, and 4.06° C (9.1%) under RCP8.5. Such changes in East Asia are all larger than the corresponding global changes, with greater differences under the higher RCPs. In the simulation of RCP4.5, which is extended to the late 23rd century (22802299), further warming of 0.34° C relative to 20802099 is found in East Asia; this is lower than the global mean warming (0.56° C). Under mitigation scenario RCP2.6, East Asia experiences greater cooling than that experienced globally throughout the 22nd and 23rd centuries. In the late 21st century, East Asian summer mean precipitation increases prominently (by 1015%) with respect to the present climatology under all RCPs. This increase in precipitation occurs primarily in southern China and northern East Asia and is associated with anomalous southerly flow in the lower troposphere. Drought occurs in the Yangtze River valley for the middle and high RCPs; we attribute this to anomalous subsidence around 30° N associated with the northward shift of the East Asian jet stream. Under the high scenario (RCP8.5), the western Pacific subtropical high extends westward and northward to southern China and is partly responsible for the deficient precipitation in regions to the south of the Yangtze River.
Kyoto's event-driven x-ray astronomy SOI pixel sensor for the FORCE mission

We have been developing monolithic active pixel sensors, X-ray Astronomy SOI pixel sensors, XRPIXs, based on a Silicon-On-Insulator (SOI) CMOS technology as soft X-ray sensors for a future Japanese mission, FORCE (Focusing On Relativistic universe and Cosmic Evolution). The mission is characterized by broadband (1-80 keV) X-ray imaging spectroscopy with high angular resolution (< 15 arcsec), with which we can achieve about ten times higher sensitivity in comparison to the previous missions above 10 keV. Immediate readout of only those pixels hit by an X-ray is available by an event trigger output function implemented in each pixel with the time resolution higher than 10 µsec (Event-Driven readout mode). It allows us to do fast timing observation and also reduces non-X-ray background dominating at a high X-ray energy band above 5{10 keV by adopting an anti-coincidence technique. In this paper, we introduce our latest results from the developments of the XRPIXs. (1) We successfully developed a 3-side buttable back-side illumination device with an imaging area size of 21.9 mm x 13.8 mm and an pixel size of 36 µm x 36 µm. The X-ray throughput with the device reaches higher than 0.57 kHz in the Event-Driven readout mode. (2) We developed a device using the double SOI structure and found that the structure improves the spectral performance in the Event-Driven readout mode by suppressing the capacitive coupling interference between the sensor and circuit layers. (3) We also developed a new device equipped with the Pinned Depleted Diode structure and confirmed that the structure reduces the dark current generated at the interface region between the sensor and the SiO2 insulator layers. The device shows an energy resolution of 216 eV in FWHM at 6.4 keV in the Event-Driven readout mode.