Miracle-dz/UniFAR-FTUs huggingface dataset:
Heparan Sulfate Proteoglycans as Adhesive and Anti-invasive Molecules SYNDECANS AND GLYPICAN HAVE DISTINCT FUNCTIONS*

were harvested by centrifugation and resuspended in RPMI 1640 con- taining 0.1% BSA (Sigma) and 2.5 units/ml PI-PLC (Boehringer Mann-heim) and incubated for 30 min at 37 °C. Following centrifugation, the supernatant was brought to 6 M urea and 50 m M sodium acetate, pH 4.5. Equal fractions of the supernatants were loaded onto Gene-Trans mem- brane (Plasco, Woburn, MA) using an immunoblot apparatus (Milliblot D; Millipore, Bedford, MA). The membrane was probed with monoclonal antibody 281.2 (10 m g/ml) in Blotto (3% powdered milk, 0.5% BSA, 10 m M Tris, pH 8.0, 0.15 M NaCl, 0.3% Tween 20, and 0.025% NaN 3 ) followed by a biotinylated rabbit anti-rat IgG (5 m g/ml) (Vector Labo-ratories, Burlingame, CA) in PBS. Bound antibody was detected using avidin-horseradish peroxidase and color developed with diaminobenzi-dine (Vector Laboratories). To confirm that the glyp/syn chimera con- tained the syndecan-1 cytoplasmic domain, cells bearing the chimeric proteoglycan were extracted with buffer containing 20 m M Tris, pH 7.4, 1% Triton X-100, 0.15 M NaCl, 5 m M N -ethylmaleimide, 5 m M benza-midine, and 1 m M phenylmethylsulfonyl fluoride on ice for 30 min. The extracts were clarified by centrifugation, and the supernatants were brought to 6 M urea and 50 m M sodium acetate, pH 4.5, and subjected to dot blotting as described above. The membrane was probed with an antiserum generated against a 7-amino acid peptide corresponding to the 7 C-terminal amino acids that are present within the syndecan-1 cytoplasmic domain (12) followed by a biotinylated goat anti-rabbit IgG (5
NDT_A_282554 2053..2062

1Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA; 2Department of Psychiatry, New York State Psychiatric Institute, New York, NY, USA Abstract: Studies using functional magnetic resonance imaging (fMRI) have contributed to our understanding of possible neural abnormalities among individuals with eating disorders. Many of these studies have focused on three domains: 1) cognitive control, 2) reward processing, and 3) affective processing. This review attempts to summarize the recent fMRI findings across these domains among the most well-characterized eating disorders: anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). Though the literature is a bit murky, a few major themes have emerged. Cognitive control systems are affected among individuals across eating disorder diagnoses, but effects seem least pronounced in AN. Specifically, individuals with all eating disorders appear to show decreased prefrontal activation during cognitive control, but there is less evidence in AN linking decreased prefrontal activation with behavior. There is some evidence that the reinforcing value of food is reduced in AN, but individuals with BN and BED show hyperactivation to rewarding food-related stimuli, suggesting the reinforcing value of food may be enhanced. However, more complex reward processing paradigms show that individuals with BN and BED exhibit hypoactivation to reward anticipation and provide mixed results with regards to reward receipt. There are fewer neuroimaging findings related to affective processing, yet behavioral findings suggest affective processing is important in understanding eating disorders. Though the extant literature is complicated, these studies represent a foundation from which to build and provide insight into potential neurobiological mechanisms that may contribute to the pathophysiology of eating disorders.
Prolonged Profound Hypoxia and Cardiac Failure in a Young Woman Presenting to the Unexpected Pulmonary Embolus, Catheter-Directed and Subsequent Failure

: Pulmonary emboli are rare occurrences in young patients, especially those who present precipitously to the emergency department. In a young unresponsive patient, recognition of thromboembolic etiology may be delayed due to atypical presenting physiology or competing diagnoses. In this report, the authors describe an initially confounding case of cata-strophic bilateral pulmonary emboli in a young woman who presented to the emergency department having been found unconscious on the street. Despite severe and prolonged hypoxia as well as multi-organ failure, the patient achieved a near complete recovery.
Effective international expansion strategies for hotel companies

II DECLARATION . IV DEDICATIONS AND ACKNOWLEDGEMENTS . V LIST OF FIGURES . XI CHAPTER 1: INTRODUCTION . 1 1.1.1 PURPOSE OF THE STUDY . 1 1.1.2 EXPANSION OPPORTUNITIES IN SOUTH AFRICA SINCE 1994 . 2 1.1.3 TARGETING DEVELOPING ECONOMIES.2 1.1.4 CHALLENGES IN EXPANDING CROSS BORDER.3 1.2 PROBLEM STATEMENT . 5 1.2. 1 MAIN PROBLEM . 5 1.2. 2 SUB-PROBLEMS . 5 1.3 DELIMITATION OF THE RESEARCH . 6 1.3. 1 INDUSTRY . 6 1.3. 2 SIZE OF THE INDUSTRY.7 1.3. 3 GEOGRAPHIC DEMARCATION. 7 1.4 DEFINITION OF KEY CONCEPTS . 7 1.4. 1 THE TERM GLOBALISATION . 7 1.4. 2 STRATEGY . 7 1.4. 3 LOCATION ECONOMIES . 8 1.4. 4 LEARNING EFFECTS . 8 1.4. 5 CORE COMPETENCIES . 8 1.4. 6 GLOBAL LEARNING . 8 1.4. 7 COMPETITIVE ADVANTAGE . 9
Distributed Control Plane Optimization in SDN-Fog VANET

— Vehicular Ad-hoc Networks (VANETs) migrate today towards emergent Internet of Vehicles (IoV), which promises advanced commercial and technical capabilities. IoV can be supported by other novel technologies like Cloud/Fog computing, Software Defined Networking (SDN) and Network Function Virtualization (NFV). However, a challenge in terms of cooperation is related to the distributed characteristic of IoV and logical centralization concept in SDN. A physically distributed SDN control plane could be a solution. This paper is a preliminary work proposing an IoV Fog-based architecture and a distributed SDN control plane. A specific problem is solved, to optimize the geographic placement of the SDN controllers based on multi-criteria optimization algorithms.
Analysing Performance of Small Business Servers

: Analysing the performance evaluation of Small Business Servers of client computers in Real time by deploying each sets of client computers with different servers such as fedora 21, Hadoop, Zentyal servers. Now by observing the data transfer and performance rate the best performance server is going to be identified and the amount of data transfer is calculated. Hence the drawback of servers are noted.
Virtualizing Reconﬁgurable Hardware to Provide Scalability in Cloud Architectures

—Field Programmable Gate Arrays (FPGAs) provide a promising opportunity to improve performance, security and energy efﬁciency of computing architectures, which are essential in modern data centers. Especially the background acceleration of complex and computationally intensive tasks is an important ﬁeld of application. The ﬂexible use of reconﬁgurable devices within a cloud context requires abstraction from the actual hardware through virtualization to offer these resources to service providers. In this paper, we enhance our related Reconﬁgurable Common Computing Frame (RC2F) approach, which is inspired by system virtual machines, for the profound virtualization of reconﬁgurable hardware in cloud services. Using partial recon-ﬁguration, our hardware and software framework virtualizes physical FPGAs to provide multiple independent user designs on a single device. Essential components are the management of the virtual user-deﬁned accelerators (vFPGAs), as well as their migration between physical FPGAs to achieve higher system-wide utilization levels. We create homogenous partitions on top of an inhomogeneous FPGA fabric to offer an abstraction from physical location, size and access to the real hardware. We demonstrate the possibilities and the resource trade-off of our approach in a basic scenario. Moreover, we present future perspectives for the use of FPGAs in cloud-based environments.
The Eﬀect of Hands-Free Cell Phone Conversation on Psychomotor Performance Required for Safe Driving: A Quasi-Experimental Study

Background: Hands-free cell phone conversation (HFCC) while driving is a common practice among drivers. Several studies have revealedthatHFCC,whiledriving,isnosaferthanhand-heldcellphoneconversations(HHCC). Thisstudywasconductedtoexplore the inﬂuence of HFCC on the psychomotor performance of drivers. Methods: In this quasi-experimental study, the participants were randomly allocated into 2 groups. Participants in group1 passed the traﬃc psychological battery of the Vienna test system (VTS) once without being engaged in any phone conversation and again while making a HFCC. The order of testing in the 2nd group was reversed. All participants shifted their group and passed the tests in a reverse order after 7 to 10 days. The tests included peripheral perception, perceptual speed, general intelligence, visuomotor coordination, and time anticipation. The mixed model analysis was used to assess the association of HFCC with every test. Results: A total of 24 students, with a mean age of 27.1 ± 5.3 years, were included in the study. HFCC had a signiﬁcant negative inﬂuenceontheoverallmeanduration(Pvalue=0.015),overallpercenterrorduration(Pvalue< 0.001)invisuomotorcoordination median deviation time (P value = 0.007) in time anticipation, divided attention in peripheral perception test (P value = 0.053), and general intelligence (P value = 0.005). However, perceptual speed and ﬁeld of vision did not reveal any signiﬁcant association. Conclusions: These ﬁndings provided further evidence of the adverse eﬀects of HFCC during driving. Even though drivers can per-ceiveanobstaclewhiletalkingonahands-freecellphone,theyarehighlylikelytoreactincorrectlyduetoimpairmentofvisuomotor coordination, time anticipation, divided attention, and ﬂuid intelligence.
C OMPREHENSIVE A NALYSIS A ND S IMULATION O F M ULTILEVEL P OWER C ONVERTERS T O C URTAIL T OTAL H ARMONIC D ISTORTION

Present day industrial applications require higher power apparatus for power conversion. At medium voltage grid, to connect only one power semiconductor switch directly is a not practically successful concept. To overcome this multilevel power converter structure has been introduced and studied as an alternative in high power and medium voltage applications. Renewable energy sources like photovoltaic, wind, fuel cells can be conveniently interfaced to a multilevel converter system for high power applications. In this study it is discussed in detail for different levels of the multilevel converters using pulse width modulation technique (PWM) the harmonics contents decreases gradually. The simulated results are presented and compared thereafter. Total harmonic distortion decreases as the number of levels increased are tabulated accordingly. All the simulation results are carried out under MATLAB/Simulink environment.
Clinical Relevance of Immunoresistance to Botulinum Therapy Clinical Relevance of Immunoresistance to Botulinum Therapy

Because botulinum toxin is a bacterial antigen, the therapy with this biological bears the risk that the formation of antibodies is elicited which can neutralize the neurotoxin. Several factors have an impact on this immune response. There are (unknown) patient- related factors but also the dose, the injection interval and the purity of the product play a role in the formation of antibodies. Several assays to detect antibodies are available; immunological assays such as FIA (fluorescence immunoassay) and ELISA, function assays such as MPA (mouse protection assay) and HDA (hemidiaphragm assay), clinical assays such as the EDB assay (extensor digitorum brevis assay), and SCM assay (sternocleidomastoid) which have different sensitivities. Clinical studies with different BoNT/A products demonstrate that the rate of antibody formation is low. Important for the physician is whether the antibody formation has an impact on the responsiveness of the patient. Not all patients with positive sera are nonresponders. The antibody titer is certainly important which might not be high enough to neutralize the injected dose completely but the titer might increase during further treatment with the neurotoxin leading to complete nonresponse. To avoid the formation of antibodies, the lowest dose necessary for the patient should be injected keeping the longest acceptable injection interval.
MICROPLANE MODEL WITH INITIAL AND DAMAGE-INDUCED ANISOTROPY APPLIED TO TEXTILE-REINFORCED CONCRETE

The presented material model reproduces the anisotropic characteristics of textile reinforced concrete in a smeared manner. This includes both the initial anisotropy introduced by the textile reinforcement, as well as the anisotropic damage evolution reﬂecting ﬁne patterns of crack bridges. The model is based on the microplane approach. The direction-dependent representation of the material structure into oriented microplanes provides a ﬂexible way to introduce the initial anisotropy. The microplanes oriented in a yarn direction are associated with modiﬁed damage laws that reﬂect the tension-stiffening effect due to the multiple cracking of the matrix along the yarn.
Inﬂuence of sex and age on long-term survival in systematic off-pump coronary artery bypass surgery

Background: Off-pump coronary artery bypass surgery (OPCAB) is commonly used as an alternative to conventional on-pump coronary artery revascularization. Historically, sex and age have been shown to adversely affect operative mortality risk as well as long-term survival in conventional surgery. Aims of the study: To evaluate the effect of gender and ageing on long-term mortality following OPCAB surgery. Methods: We have prospectively followed up 1000 consecutive and systematic OPCAB patients operated between September 1996 and April 2003. Average follow-up period was 64 (cid:2) 28 months and was complete in 98% of the cohort. Results: There were 223 women (21%) and 777 men (79%). Women were older, 68 (cid:2) 10 versus 63 (cid:2) 10 years ( p < 0.0001) and had higher prevalence of hypertension ( p < 0.0001), peripheral vascular disease (PVD) ( p = 0.03), recent myocardial infarction ( p = 0.04) and a smaller body surface ( p < 0.0001). History of congestive heart failure (CHF) ( p = 0.001) and unstable angina ( p = 0.003) was more frequent in men. Operative mortality was 2.8% in women and 1.4% in men ( p = ns). Eight-year survival was 79 (cid:2) 2.5% for men and 68 (cid:2) 5% for women, ( p = 0.02). Cox regression analysis model revealed that age (HR: 2.81; 95% CI: 1.89—4.18), CHF (HR: 2.09; 95% CI: 1.33—3.31), PVD (HR: 1.72; 95% CI: 1.10—2.5), incomplete revascularization (HR: 2.35; 1.37—4.02), multiple internal thoracic artery (MITA) graft/patient (ITA/pt) (HR: 0.61; 95% CI: 0.44—0.84), left ventricular ejection fraction (LVEF) (HR: 0.19; 95% CI: 0.05—0.71) and cerebral vascular disease (HR: 1.50; 95% CI: 1.00—2.24) but not female sex ( p = 0.89) were signiﬁcant predictors of long-term mortality. Above 65 yearsofage menandwomenhada comparableoverallsurvival( p = 0.7)whereasfewerthan65womenhada lowersurvivalthanmen( p = 0.001). CoxregressionrevealedthatLVEF(HR: 0.06;95%CI:0.006—0.59),lesseruseofMITAgraft (HR:0.45;95%CI:0.35—0.79),weresigniﬁcantcausesof long-term mortality inthe younger cohort. Female genderdid not reach statisticalsigniﬁcance ( p = 0.12). Conclusion : In this series of systematic OPCAB surgery, the lower survival rate observed in younger women was mostly related to a higher prevalence of preoperative comorbidity and a lesser use of MITA grafts than gender itself.
Identification of a Novel Partner of Duox EFP1, A THIOREDOXIN-RELATED PROTEIN*

H 2 O 2 is a crucial substrate of thyroproxidase (TPO) to iodinate thyroglobulin and synthesize thyroid hormones in thyroid. ThOX proteins (thyroid oxidase) also called Duox are believed to be responsible for H 2 O 2 generation. Duoxs expressed in transfected cells do not generate an active system, nor permit their membrane localization suggesting that other proteins are required to fulfill these functions. In this study, we demonstrate interactions of Duoxs with TPO and with p22 phox without any effect on Duox activity. By yeast two-hybrid method using EF-hand fragment of dog Duox1 as the bait we have isolated EFP1 (EF-hand binding protein 1), one partner of Duoxs that belongs to the thioredoxin-related protein family. EFP1 shares moderate similarities with other members of thiore-doxin-related proteins, but the characteristic active site and the folding structures are well conserved. EFP1 can be co-immunoprecipitated with Duoxs in transfected COS cells as well as in primary cultured human thyrocytes. It interacts also with TPO but not thyroglobulin. Immunofluorescence studies show that EFP1 and Duox proteins are co-localized inside the transfected cells, suggesting that EFP1 is not sufficient to induce either the expression of Duox at the plasma membrane or to permit H 2 O 2 production. EFP1 and Duox mRNA share similar distribution
EDUCATIONAL RESEARCH IN ACTION Developing a standardized curriculum for teaching chiropractic technique: Qualitative analysis of participants’ opinions from 4 intercollegiate conference workshops

Objective: This is a report of the results of 4 facilitated workshops aimed at developing a standardized chiropractic technique curriculum. Methods: Workshops were held at research conferences during 2014, 2016, 2018, and 2019. Participants were tasked with developing recommendations for diagnostic and therapeutic procedures appropriate for chiropractic technique programs. Results: For diagnostic procedures, there was general agreement among participants that chiropractic programs should include diagnostic imaging, postural assessment, gait analysis, palpation (static, motion, and joint play/springing), global range of motion, and evidence-based orthopedic/neurological tests. No consensus could be reached with respect to chiropractic x-ray line marking (spinography) nor heat sensing instruments, and there was only partial consensus on leg length assessment. For therapeutic procedures, all participants agreed that the following should be included: high-velocity, low amplitude spinal and extremity manipulation, adjustments assisted by hand-held instruments, drop tables, ﬂexion-distraction tables, and pelvic blocks. There was unanimous support for teaching mobilization of the spine and peripheral joints, as well as for manual and instrument-assisted soft tissue therapies. There were some overarching issues: participants strongly preferred assessment methods known to be reliable and valid and therapeutic procedures known to be safe and effective. Where evidence was lacking, they insisted that diagnostic and therapeutic methods at minimum have face validity and biological plausibility. However, they cautioned against applying aspects of evidence-based care too rigidly. Conclusions: Despite differing views on chiropractic terminology, philosophy, and scope of practice, participants’ opinions were similar regarding diagnostic and therapeutic procedures that ought to be included in chiropractic technique programs.
The Journal of Academic Librarianship Information literacy and fake news: How the ﬁ eld of librarianship can help combat the epidemic of fake news

This paper studies how the ﬁ eld of librarianship can help counteract the phenomenon of fake news and mis- information. A literature review was conducted to identify the current themes, patterns, correlations and gaps within the existing literature on fake news, information literacy and librarianship. Findings centre on de ﬁ ning fake news, analysing contemporary and emerging information literacy frameworks, and outlining the current e ﬀ orts and initiatives exercised by libraries to refute the spread of fake news and educate communities on how to navigate through an era of untruth and disinformation. The paper outlines e ﬀ ective initiatives developed by those within the Library and Information Systems (LIS) profession while highlighting considerations and re- commendations as to how librarians can continue to enhance their role in the digital age and make successful contributions to the professional ﬁ eld.
prevents pathological epithelial adhesions embryogenesis.

mutation in IKKA , revealed an absence of periderm. Together, these data indicate that periderm plays a transient but fundamental role during embryogenesis by acting as a protective barrier that prevents pathological adhesion between immature, adhesion-competent epithelia. Furthermore, this study suggests that failure of periderm formation underlies a series of devastating birth defects, including popliteal pterygium syndrome, cocoon syndrome, and Bartsocas-Papas syndrome.
Human Memory Encoding and Orchestration

Theoretical exploration plays an indispensable role in human memory research due to ethical constrains. In this study, a novel framework for memory encoding and orchestration is developed as follows: All human memories are physically encoded by meaningful synaptic pairs, which indivisibly constitute the smallest memory unit (SMU) capable of encoding memories regardless of synaptic strength and maturity state. Highly streamlined images projected onto the visual cortex are faithfully encoded by SMU involving adjacently interconnected neurons, while verbal, auditory and olfactory memories are encoded by an individually varied combination of SMU in a neuron-specific manner. Similar categories of memories are vertically orchestrated into a pyramid architecture known as the pyramidal memory islet (PMI) dominated by a language-based abstract concept at the apex. Following encoding in situ in the neocortex rather than transferred from elsewhere, successful cross-indexing in hippocampus guides the integration of new memories into PMI and concomitantly triggers biochemical cascades characterized by alternate protein synthesis and degradation. Besides memory encoding, the SMU theory can reasonably explain certain puzzling phenomena such as human dreams. Keywords—memory storage mechanism, long-term memory, short-term memory, synaptic plasticity
The Recommending Courses based on the Similarity of Students’ Preferences

To keep students in touch, they need to be caught through proposing different courses similar to the ones they are interested in. The present paper is going to discuss the idea of recommending courses and how it will be applied into student profiles as the result of clustering the books or courses as well as the student preferences. It will illustrate the way the item and student profiles enable to recommend courses in our system
RIPARIAN HABITAT ALONG THE SACRAMENTO RIVER

There has been a significant reduction in the amount of riparian vegetatJ.onl along the Sacramento River since settlement began in the 1840's. Unless large scale protective measures are implemented to protect the remaining vegetation. the banks of the Sacramento River will be converted into a barren environment with very little wildlife or aesthetic values remaining.