Miracle-dz/UniFAR-FTUs huggingface dataset:
INFLUENCE OF FOOTWEAR ON THE ANKL SPRAIN PRODUCTION MECHANISM IN BASKETBALL

INTRODUCTION: Vertical jump is a usual movement pattern in basketball, and it is related to ankle injuries, mainly during rebound actions when falling on another player's foot. The aim of the present study IS to determine the influence of the introduction of certain elements in the footwear on ankle protection when falling on an irregular surface. The study consisted in simulating a rebound action in which the player jumps and falls on an irregular surface, simulated by a 20" inclined plane. 12 footwear prototypes were studied, making a factorial design with the following elements: high or low top, upper vamp stabilizer, hollow midsole at midfoot level and lace anchors. 3 test subjects, students of Physical Education, took part. They performed 36 jumps each, in series of 3, with a recovering time of 3 s between jumps and 3 m between series. Each series was done wearing one of the 12 prototypes at random. Each jump was filmed at 150 Hz and then digitized. The angles of knee and ankle were calculated as a function of time. For the statistical analysis an analysis of variance (ANOVA) was made, considering as factors the elements introduced in the footwear and a level of significance of 0,05 was chosen. RESULTS: The results indicate the high top footwear limited the range of movement during ankle flexion-extension and they produce higher values of inversion than low top. With an upper vamp stabilizer, higher values of inversion were obtained than without it. On the other hand, with a hollow midsole, inversion values were lower. Introducing a movement control system in the rearfoot, by means of lace anchors, did not show influence on the studied movements. CONCLUSIONS: In this way, after landing on an irregular surface, the high top as well as an upper vamp stabilizer increase the degree of inversion, probably because these elements rigidify vertically the footwear and increase the adherence to the floor or to the irregular surface on which the subject IS. However, it must be considered that epidemiological studies state that high top footwear diminish the risk of acute ankle injuries in basketball players. The upper vamp stabilizer, on the contrary, only rigidifies vertically the footwear and it dos not offer any extra reinforcement of the joint, increasing the risk of suffering ankle injuries. REFERENCES: Stacoff, A. ; Kalin, X. ; Stiitsi, E. (1 989) Torsional movements of the foot during landing. Abstracs of the XI1 Congress of the International Society of Biomechanics. Los Angeles, 1085. Sussman, D. H. ; Hamill, J.; Miller, M. (1988) Effect of shoe height and prophylactic taping on ankle joint motion during s~mulated basketball rebounding. In De Groot, G. , Hollander, A.P.; Huijing, P.A. ; Van lngen Schenau, G.J. (Eds.) Biomechanics XI-6.
Søk etter døde fugler i Smøla vindpark 2011-2013

4 Innhold . 5 Forord . 6 1 Innledning . 7 2 Døde fugler i vindpark – registrering og søkeregimer . 8 2.1 Døde og skadede fugler i vindpark . 8 2.2 Forsvinning av død fugl . 10 2.3 Å finne og registrere døde fugler – mange utfordringer . 11 2.4 Registreringsog søkeregimer i Smøla vindpark . 14 3 Metoder . 17 3.1 Registreringsmetoder generelt . 17 3.2 Bruk av fjærsøkshund til å søke . 18 3.3 Rutiner i søk og ved funn . 21 4 Funn av døde fugler 2013 . 22 4.1 Fordeling av funn 2013 på funnmåter og metoder . 22 4.2 Registrerte funn av havørn 2013 . 23 4.3 Registrerte funn av andre arter 2013 . 27 4.4 INTACT turbiner høsten 2013 – tilleggs søk og funn . 29 5 Årene 2011-2013 oppsummert . 30 6 Betydning av søkeinnsats . 32 7 Døde havørner – kvantitative forhold . 35 7.1 Kronologisk oversikt Smøla vindpark . 35 7.2 Søkeinnsats og havørnfunn august 2006 – november 2013 . 35 7.3 Registrerte antall døde havørner . 36 8 Veien videre. 37 9 Referanser . 38 Vedlegg . 41 Vedlegg 1: Terminologi. 41 Vedlegg 2: Søksskjema benyttet i Smøla vindpark . 44 Vedlegg 3: Observasjon levende fugler under turbinsøk . 45 Vedlegg 4: Observasjon av fugl på søksdagene – med kart . 46 Vedlegg 5: Funnskjema benyttet ved funn av døde fugler . 48 Vedlegg 6: Feltarbeid i 2011-2013 . 49 Vedlegg 7: Obduksjonsrapport jaktfalk 2013 . 52
Prognostic role of SPRY4-IT1 in female breast carcinoma and malignant tumors of the reproductive system

Abstract Background: The prognostic value of SPRY4-Intronic transcript 1 (SPRY4-IT1) in women suffering from breast carcinoma and malignant tumors of the reproductive system remains to be ascertained. Therefore, this paper attempted to assess the relationship between SPRY4-IT1 with the clinicopathological indicators and survival analysis in women suffering from breast carcinoma and malignant tumors of their reproductive organs through meta-analysis. Method: Related literature retrieved from Cochrane Library, Ovid, Embase, PubMed, the CNKI, and the Web of Science databases were reviewed. The latest article search was updated to September 1, 2021. The outcome indicators included as effective measures in the study were hazard ratio (HR), odds ratio (OR), and 95% confidence interval (CI). The Stata 12.0 software was used to analyze the data. Results: The elevated SPRY4-IT1 levels were indicative of poor overall survival (OS) [HR = 2.44, 95% CI = 1.35–4.43, P < . 05], and were not related to Disease-Free Survival (DFS) [HR = 1.61, 95% CI = 0.50–5.18, P = . 43] in female patients suffering from malignant tumors. In terms of lymph node metastasis (LNM) for the association between long noncoding RNA SPRY4-IT1(LncRNA SPRY4-IT1) and OS, elevated LncRNA SPRY4-IT1 implied poor OS with LNM [HR = 2.79, 95% CI: 1.81–4.28, P < . 001]. Based on the aspect of the LNM for the association between LncRNA SPRY4-IT1 and DFS, SPRY4-IT1 was not correlated with DFS [HR = 0.97, 95% CI: 0.73–1.28, P = . 81]. SPRY4-IT1 in the TNM stage was not related to OS [HR = 1.43, 95% CI: 0.55–3.70, P = . 46]. In the TNM stage, SPRY4-IT1 was not related to DFS [HR = 1.68, 95% CI: 0.92–3.06, P = . 09]. SPRY4-IT1 was found to be associated with lymph node metastasis (OR = 4.15, 95% CI: 2.75–6.25, P = .000) and TNM stage (OR = 2.89, 95% CI: 1.51–7.27 P = .02). No significant correlation was noted between SPRY4-IT1 and the age of the patients (OR = 0.89, 95% CI: 0.61–1.29 P = .54). Conclusions: Thus, this study provides evidence-based medical evidence for the target treatment of female breast carcinoma and malignant tumors of the reproductive system. The elevated level of SPRY4-IT1 was associated with poor prognosis of female breast cancer patients and of those having malignant tumors in their reproductive organs. In addition, the SPRY4-IT1 expression was also associated with the disease progression and metastasis.
Effect of Low Temperature Sintering on the Porosity and Microstructure of Porous Zeolite Ceramic

Manufacturing a porous ceramic specimen from natural zeolite materials mined in Malang, Indonesia was conducted by using a low temperature sintering. In this study, a porous ceramic property with rectangular shaped and prism shaped fillets at each end were sintered at 800-900°C and finally were investigated. Density and porosity measurements were performed using Archimedes method. The microstructure photos were used to measure the neck diameter and the contact angle between the two grains particles and two-dimensional porosity. The result of the zeolite ceramic measurement shows that the higher the sintering temperature the higher the density value and the smaller the open porosity. While from the microstructure photo it is shown that the neck diameter was larger the contact angle was wider. This phenomenon was happened because of the flux diffusion on the grain boundaries. This diffusion flow condition would influence the specimen surface, volume and grain boundary so that the porous ceramic density increases.
Recent Developments in Mouse Trauma Research Models: A Mini-Review

The urgency to investigate trauma in a controlled and reproducible environment rises since multiple trauma still account for the most deaths for people under the age of 45. The most common multiple trauma include head as well as blunt thorax trauma along with fractures. However, these trauma remain difficult to treat, partially because the molecular mechanisms that trigger the immediate immune response are not fully elucidated. To illuminate these mechanisms, investigators have used animal models, primarily mice as research subjects. This mini review aims to 1) emphasize the importance of the development of clinically relevant murine trauma research, 2) highlight and discuss the existing conflict between simulating clinically relevant situations and elucidating molecular mechanisms, 3) describe the advantages and disadvantages of established mouse trauma models developed to simulate clinically relevant situations, 4) summarize and list established mouse models in the field of trauma research developed to simulate clinically relevant situations.
Attentional Prioritization of Complex, Naturalistic Stimuli Maintained in Working-Memory–A Dot-Probe Event-Related Potentials Study

Recent studies suggest that a stimulus actively maintained in working memory (WM) automatically captures visual attention when subsequently perceived. Such a WM-based guidance effect has been consistently observed for stimuli defined by simple features, such as color or orientation, but studies using more complex stimuli provided inconclusive results. Therefore, we investigated whether the WM-based guidance effect occurs also for naturalistic stimuli, whose identity is defined by multiple features and relations among them, specifically for faces and houses. The experiment consisted of multiple blocks in which participants (N = 28) either memorized or merely saw (WM or exposure condition, respectively) a template stimulus and then performed several dot-probe trials, with pairs of stimuli (template and control) presented laterally as distractors and followed by a target-asterisk. Analysis of reaction-times (RT) in the dot-probe task shows that memorized stimuli were prioritized by attention and points toward attention-hold, rather than capture, as a mechanism of attentional prioritization. Consistent with this interpretation, memorized items did not evoke a lateralized N2pc ERP component, thought to indicate attention shifts. However, in an exploratory ERP analysis we found evidence for a very early (100–200 ms post-stimulus) prioritization specific to the memorized faces, which is in line with the sensory recruitment theory of WM. In conclusion, our data provide evidence that complex stimuli are prioritized by attention when maintained in WM, and that the mechanism of such prioritization is based on a prolonged hold of spatial attention.
Utility of Whole Genome Sequencing for Population Screening of Deafness-Related Genetic Variants and Cytomegalovirus Infection in Newborns

Background: Hearing loss affects approximately two out of every 1,000 newborns. Genetic factors and congenital cytomegalovirus (CMV) infections account for around 90% of the etiology. The purpose of this study was to develop and test a whole genome sequencing (WGS) approach to detect deafness-related genetic variants and CMV infections simultaneously in newborns. Method: Deafness-related genes causing congenital or childhood hearing loss were curated and selected for newborn screening. Nine dried blood spots from newborns with known genetic variants (n = 6) or CMV infections (n = 3) were employed to develop and validate the WGS testing and analytic pipeline. We then pilot tested the WGS analysis on 51 de-identified clinical samples. Results: 92 gene-disease pairs were selected for screening hearing loss in newborns. In the validation test, WGS accurately detected all types of genetic variants, including single nucleotide variations, insertions/deletions, and copy number variations in the nuclear or mitochondrial genome. Sequence reads mapping to the CMV reference genome were discovered in CMV infected samples. In the pilot test, WGS identified nine out of 51 (18%) newborns carrying pathogenic variants associated with deafness. Conclusion: WGS can simultaneously detect genetic variants and CMV infections in dried blood spot specimens from newborns. Our study provides proof of principle that genome sequencing can be a promising alternative for newborn screening of hearing loss.
Adaptive Pathways of Microorganisms to Cope With the Shift From P- to N-Limitation in Subtropical Plantations

Ecological stoichiometry is increasingly acknowledged as one of the main control factors for microbial activity and diversity. Soil carbon/nitrogen (C/N) and carbon/phosphorus (C/P) ratios are usually much higher than microbial nutrient requirements and vary with planting density and stand age in forestlands. However, how microorganisms cope with such stoichiometric imbalances and how they regulate nutrient cycling remain unclear. Here, 5- and 35-year-old experimental Cunninghamia lanceolata [Lamb. ] Hook plantations with five planting densities (1,667, 3,333, 5,000, 6,667, and 10,000 stems ha−1) were used to explore the underlying mechanism of the response of microorganisms to stoichiometric imbalances. We found that (i) enzyme activity and microbial biomass and diversity increased with planting density at age 5 but decreased at age 35; (ii) soil microorganisms were P-limited at age 5, but gradually shifted from P- to N-limitation during the development of plantations from 5 to 35 years; and (iii) significantly negative relationships between microbial biomass stoichiometry and enzymatic stoichiometry were observed. The adaptive pathways of soil microorganisms to cope with stoichiometric imbalances include (i) adjusting the stoichiometry of microorganisms and enzymes; (ii) changing the relative abundance of the dominant microbial phyla; and (iii) increasing the ratio of fungal to bacterial diversity. These results highlight how to use the ecological stoichiometry method to identify soil microbial nutrient limitations with planting density during the development of plantations. By underlining the important role of stoichiometry on microbial growth and activity, these findings furthermore emphasize the dependency of organic matter transformation and nutrient cycling on the microbial community.
Oxytocin and Related Peptide Hormones: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis

Sepsis is a potentially life-threatening systemic inflammatory syndrome characterized by dysregulated host immunological responses to infection. Uncontrolled immune cell activation and exponential elevation in circulating cytokines can lead to sepsis, septic shock, multiple organ dysfunction syndrome, and death. Sepsis is associated with high re-hospitalization and recovery may be incomplete, with long term sequelae including post-sepsis syndrome. Consequently, sepsis continues to be a leading cause of morbidity and mortality across the world. In our recent review of human chorionic gonadotropin (hCG), we noted that its major properties including promotion of fertility, parturition, and lactation were described over a century ago. By contrast, the anti-inflammatory properties of this hormone have been recognized only more recently. Vasopressin, a hormone best known for its anti-diuretic effect, also has anti-inflammatory actions. Surprisingly, vasopressin’s close cousin, oxytocin, has broader and more potent anti-inflammatory effects than vasopressin and a larger number of pre-clinical studies supporting its potential role in limiting sepsis-associated organ damage. This review explores possible links between oxytocin and related octapeptide hormones and sepsis-related modulation of pro-inflammatory and anti-inflammatory activities.
Sensory Experiences and Children With Severe Disabilities: Impacts on Learning

The human sensory system is continuously engaged in experiencing and interpreting every interaction with other living beings, objects, and the environment. The purpose of this article is to describe the impact limited opportunities for rich sensory experiences have on students with severe disabilities in two middle school classrooms situated in a public separate school in the southeastern USA. The study employed a postcritical ethnographic approach and grounded theory thematic analysis of fieldnotes gathered over a two-year period. Three major themes supported by the data are presented and discussed in depth. They are: (a) students are afforded limited sensory rich experiences, (b) everyday routines make students passive recipients to school, and (c) instructional approaches result in little interaction with extended periods of waiting. The implications of the findings for improved sensory experiences and possible future directions are described.
Validation of Risk Scores for Predicting Atrial Fibrillation Detected After Stroke Based on an Electronic Medical Record Algorithm: A Registry-Claims-Electronic Medical Record Linked Data Study

Background Poststroke atrial fibrillation (AF) screening aids decisions regarding the optimal secondary prevention strategies in patients with acute ischemic stroke (AIS). We used an electronic medical record (EMR) algorithm to identify AF in a cohort of AIS patients, which were used to validate eight risk scores for predicting AF detected after stroke (AFDAS). Methods We used linked data between a hospital stroke registry and a deidentified database including EMRs and administrative claims data. EMR algorithms were constructed to identify AF using diagnostic and medication codes as well as free clinical text. Based on the optimal EMR algorithm, the incidence rate of AFDAS was estimated. The predictive performance of 8 risk scores including AS5F, C2HEST, CHADS2, CHA2DS2-VASc, CHASE-LESS, HATCH, HAVOC, and Re-CHARGE-AF scores, were compared using the C-index, net reclassification improvement, integrated discrimination improvement, calibration curve, and decision curve analysis. Results The algorithm that defines AF as any positive mention of AF-related keywords in electrocardiography or echocardiography reports, or presence of diagnostic codes of AF was used to identify AF. Among the 5,412 AIS patients without known AF at stroke admission, the incidence rate of AFDAS was 84.5 per 1,000 person-year. The CHASE-LESS and AS5F scores were well calibrated and showed comparable C-indices (0.741 versus 0.730, p = 0.223), which were significantly higher than the other risk scores. Conclusion The CHASE-LESS and AS5F scores demonstrated adequate discrimination and calibration for predicting AFDAS. Both simple risk scores may help select patients for intensive AF monitoring.
The Ins and Outs of Antigen Uptake in B cells

A review of our current knowledge of B cell antigen uptake mechanisms, the relevance of these processes to pathology, and outstanding questions in the field. Specific antigens induce B cell activation through the B cell receptor (BCR) which initiates downstream signaling and undergoes endocytosis. While extensive research has shed light on the signaling pathways in health and disease, the endocytic mechanisms remain largely uncharacterized. Given the importance of BCR-antigen internalization for antigen presentation in initiating adaptive immune responses and its role in autoimmunity and malignancy, understanding the molecular mechanisms represents critical, and largely untapped, potential therapeutics. In this review, we discuss recent advancements in our understanding of BCR endocytic mechanisms and the role of the actin cytoskeleton and post-translational modifications in regulating BCR uptake. We discuss dysregulated BCR endocytosis in the context of B cell malignancies and autoimmune disorders. Finally, we pose several outstanding mechanistic questions which will critically advance our understanding of the coordination between BCR endocytosis and B cell activation.
Moving to the Outskirts: Interplay Between Regulatory T Cells and Peripheral Tissues

Regulatory T cells (Tregs) restrain excessive immune responses and dampen inflammation. In addition to this classical immune suppressive role, Tregs in non-lymphoid tissues also promote tissue homeostasis, regeneration and repair. In this review, we outline our current understanding of how Tregs migrate to peripheral tissues and the factors required for their maintenance at these sites. We discuss the tissue-specific adaptations of Tregs at barrier and immuno-privileged sites and the mechanisms that regulate their function within these organs. Furthermore, we outline what is known about the interactions of Tregs with non-immune cells in the different peripheral tissues at steady state and upon challenge or tissue damage. A thorough understanding of the tissue-specific adaptations and functions of Tregs will potentially pave the way for therapeutic approaches targeting their regenerative role.
The Feasibility and Utility of Harnessing Digital Health to Understand Clinical Trajectories in Medication Treatment for Opioid Use Disorder: D-TECT Study Design and Methodological Considerations

Introduction Across the U.S., the prevalence of opioid use disorder (OUD) and the rates of opioid overdoses have risen precipitously in recent years. Several effective medications for OUD (MOUD) exist and have been shown to be life-saving. A large volume of research has identified a confluence of factors that predict attrition and continued substance use during substance use disorder treatment. However, much of this literature has examined a small set of potential moderators or mediators of outcomes in MOUD treatment and may lead to over-simplified accounts of treatment non-adherence. Digital health methodologies offer great promise for capturing intensive, longitudinal ecologically-valid data from individuals in MOUD treatment to extend our understanding of factors that impact treatment engagement and outcomes. Methods This paper describes the protocol (including the study design and methodological considerations) from a novel study supported by the National Drug Abuse Treatment Clinical Trials Network at the National Institute on Drug Abuse (NIDA). This study (D-TECT) primarily seeks to evaluate the feasibility of collecting ecological momentary assessment (EMA), smartphone and smartwatch sensor data, and social media data among patients in outpatient MOUD treatment. It secondarily seeks to examine the utility of EMA, digital sensing, and social media data (separately and compared to one another) in predicting MOUD treatment retention, opioid use events, and medication adherence [as captured in electronic health records (EHR) and EMA data]. To our knowledge, this is the first project to include all three sources of digitally derived data (EMA, digital sensing, and social media) in understanding the clinical trajectories of patients in MOUD treatment. These multiple data streams will allow us to understand the relative and combined utility of collecting digital data from these diverse data sources. The inclusion of EHR data allows us to focus on the utility of digital health data in predicting objectively measured clinical outcomes. Discussion Results may be useful in elucidating novel relations between digital data sources and OUD treatment outcomes. It may also inform approaches to enhancing outcomes measurement in clinical trials by allowing for the assessment of dynamic interactions between individuals' daily lives and their MOUD treatment response. Clinical Trial Registration Identifier: NCT04535583.