Miracle-dz/UniFAR-FTUs huggingface dataset:
A Dynamic Submaximal Fatigue Protocol Alters Wrist Biomechanical Properties and Proprioception

Fatigue is a temporary condition that arises as a result of intense and/or prolonged use of muscles and can affect skilled human performance. Therefore, the quantitative analysis of these effects is a topic of crucial interest in both ergonomics and clinical settings. This study introduced a novel protocol, based on robotic techniques, to quantitatively assess the effects of fatigue on the human wrist joint. A wrist manipulandum was used for two concurrent purposes: (1) implementing the fatigue task and (2) assessing the functional changes both before and at four time points after the end of the fatigue task. Fourteen participants completed the experimental protocol, which included the fatigue task and assessment sessions over 2 days. Specifically, the assessments performed are related to the following indicators: (1) isometric forces, (2) biomechanical properties of the wrist, (3) position sense, and (4) stretch reflexes of the muscles involved. The proposed fatigue task was a short-term, submaximal and dynamic wrist flexion/extension task designed with a torque opposing wrist flexion. A novel task termination criterion was employed and based on a percentage decrease in the mean frequency of muscles measured using surface electromyography. The muscle fatigue analysis demonstrated a change in mean frequency for both the wrist flexors and extensors, however, only the isometric flexion force decreased 4 min after the end of the task. At the same time point, wrist position sense was significantly improved and stiffness was the lowest. Viscosity presented different behaviors depending on the direction evaluated. At the end of the experiment (about 12 min after the end of the fatigue task), wrist position sense recovered to pre-fatigue values, while biomechanical properties did not return to their pre-fatigue values. Due to the wide variety of fatigue tasks proposed in the literature, it has been difficult to define a complete framework that presents the dynamic of fatigue-related changes in different components associated with wrist function. This work enables us to discuss the possible causes and the mutual relationship of the changes detected after the same task.
Activation of GIPR Exerts Analgesic and Anxiolytic-Like Effects in the Anterior Cingulate Cortex of Mice

Background Chronic pain is defined as pain that persists typically for a period of over six months. Chronic pain is often accompanied by an anxiety disorder, and these two tend to exacerbate each other. This can make the treatment of these conditions more difficult. Glucose-dependent insulinotropic polypeptide (GIP) is a member of the incretin hormone family and plays a critical role in glucose metabolism. Previous research has demonstrated the multiple roles of GIP in both physiological and pathological processes. In the central nervous system (CNS), studies of GIP are mainly focused on neurodegenerative diseases; hence, little is known about the functions of GIP in chronic pain and pain-related anxiety disorders. Methods The chronic inflammatory pain model was established by hind paw injection with complete Freund’s adjuvant (CFA) in C57BL/6 mice. GIP receptor (GIPR) agonist (D-Ala2-GIP) and antagonist (Pro3-GIP) were given by intraperitoneal injection or anterior cingulate cortex (ACC) local microinjection. Von Frey filaments and radiant heat were employed to assess the mechanical and thermal hypersensitivity. Anxiety-like behaviors were detected by open field and elevated plus maze tests. The underlying mechanisms in the peripheral nervous system and CNS were explored by GIPR shRNA knockdown in the ACC, enzyme-linked immunosorbent assay, western blot analysis, whole-cell patch-clamp recording, immunofluorescence staining and quantitative real-time PCR. Results In the present study, we found that hind paw injection with CFA induced pain sensitization and anxiety-like behaviors in mice. The expression of GIPR in the ACC was significantly higher in CFA-injected mice. D-Ala2-GIP administration by intraperitoneal or ACC local microinjection produced analgesic and anxiolytic effects; these were blocked by Pro3-GIP and GIPR shRNA knockdown in the ACC. Activation of GIPR inhibited neuroinflammation and activation of microglia, reversed the upregulation of NMDA and AMPA receptors, and suppressed the enhancement of excitatory neurotransmission in the ACC of model mice. Conclusions GIPR activation was found to produce analgesic and anxiolytic effects, which were partially due to attenuation of neuroinflammation and inhibition of excitatory transmission in the ACC. GIPR may be a suitable target for treatment of chronic inflammatory pain and pain-related anxiety.
Editorial: New Applications of Insecticidal RNAi

Gene silencing, the phenomena where genes are turned off, as a result of RNA was first reported by Napoli and Jorgensen in 1990, who discovered the phenomenon accidentally while trying to overexpress a gene in petunia (Napoli et al., 1990). Referred to as co-suppression, and “quelling” in the early literature, the mechanism of these silencing events remained a mystery until the publication of the 1998 paper from Fire and collaborators describing a mechanism for achieving specific, RNA sequence dependent gene silencing in the model nematode Caenorhabditis elegans which they termed “RNA interference” or RNAi (Fire et al., 1998). To say that this observation changed scientific research overnight would not be an overstatement. The classical genetic research paradigm was already yielding to a variety of “reverse genetic” techniques, and the discovery of this ancient, widely conserved gene silencing mechanism provided a powerful new tool for exploring the function of genes with a known sequence. Combined with the exponential growth of genomic sequence information, the process of gene discovery and characterization accelerated its transition from a slow, random process of mutagenesis and laborious genetic mapping through endless crosses and selection into one where known gene sequences could be selected based on similarity to previously known genes and their function assessed through a relatively simple assay. It is not an exaggeration to say genetic research was forever changed, and as a result Andrew Fire and Craig Mello in 2006 were awarded a Nobel Prize in Physiology or Medicine. Almost immediately, scientists began to imagine its potential for use outside of research, including in agriculture. Modern agriculture is challenged with the need for innovative crop protection technology that will support long term sustainability goals for the environment and ensure food security for the world’s rapidly increasing human population. Insects are responsible for significant crop loss, accounting for approximately 20 percent of loss on a global basis (Oerke and Dehne, 2004). Reduced reliance on synthetic chemical pesticides that may negatively impact pollinators and other beneficial insects is an aim of both private industry and governmental agencies
Detecting Boosting Weak Signal via A Meminductive Multistable Chaotic System

In this paper, we rebuild a new meminductive chaotic circuit model based on a Wien-bridge oscillator. Due to the extreme multistability of the meminductive system, it can produce the phenomenon of many infinitely coexisting attractors. Systems that spontaneously produce coexisting oscillations are relatively rare in the study of meminductive circuit systems and are well suited as pseudo-random number generators (PRNG). In this study, a new weak signal detection model is established based on the proposed meminductive system. This detection model can detect boosting weak signals with different amplitudes. The trajectory of objects can be predicted effectively by the boosting line spectrum in the frequency domain. The experimental result shows the feasibility through which the meminductive multistable system is applied in the detection field.
Identification of FCER1G related to Activated Memory CD4+ T Cells Infiltration by Gene Co-expression Network and Construction of a Risk Prediction Module in Diffuse Large B-Cell Lymphoma

Diffuse large B cell lymphoma (DLBCL) is a group of biologically heterogeneous tumors with different prognoses. The tumor microenvironment plays a vital role in the tumorigenesis and development of DLBCL, and activated memory CD4+ T cells are an essential component of immunological cells in the lymphoma microenvironment. So far, there are few reports about activated memory CD4+T cells infiltration and related genes in the DLBCL tumor microenvironment. This study obtained the mRNA expression profile information of the testing GSE87371 dataset and another six validation datasets (GSE53786, GSE181063, GSE10846, GSE32918, GSE32018, GSE9327, GSE3892, TCGA-DLBC) from the GEO and TCGA databases. Weighted Gene Co-expression Network Analysis (WGCNA) screened gene module associated with activated memory CD4+ T cells infiltration. CIBERSORT and TIMER (immune cells infiltrating estimation analysis tools) were used to identify the relationship between activated memory CD4+ T cells and genes associated with immune infiltrating cells in the tumor microenvironment. The least absolute shrinkage and selection operator (LASSO) built the risk prediction model and verified it using nomogram and Kaplan-Meier analysis. Further functional characterization includes Gene Ontology, KEGG pathway analysis and Gene Set Enrichment Analysis (GSEA) to investigate the role and underlying mechanisms of these genes. These results suggest that the expression of FCER1G can reflect the invasion of activated memory CD4+ T cells in DLBCL, which provides a new idea for studying the tumor microenvironment and may become a potential predictive biomarker for the assessment of DLBCL.
Hydrodynamic Coupling of Inverted Flags in Side-by-Side, Left Triangular and Right Triangular Configurations in a Uniform Flow

The hydrodynamic coupling of inverted flexible flags in side-by-side, left triangular and right triangular configurations in a uniform flow is investigated numerically. Various arrangements can be characterized by the lateral and longitudinal gaps, i.e., H and G, respectively. For the side-by-side configurations, three typical modes are identified in flapping region, i.e., in-phase quasi out-of-phase (QOP) and out-of-phase (OP) modes, corresponding to 2P, irregular and 4(P + S) wake patterns, respectively. Further analysis on the mean drag coefficient ( C d ̄ ) and bending energy ( E b ̄ ) indicates that the side-by-side flags can not harvest more bending energy from surrounding flows than the isolated one, except for a narrow range of H ∈ (1.8, 2.5). Moreover, an additional inverted flag is placed in front or rear of the side-by-side flags to explore possible favorable arrangements for bending energy enhancement. Three typical modes have been identified in the H − G planes for both left and right triangular configurations, i.e., the regular-coupled (RC), irregular-coupled (IC) and decoupled (DC) modes, respectively. For left triangular configurations, the overall system may experience significant performance enhancement in some favorable configurations, corresponding to harvest enhancement region (HER) in the G − H plane; For the case in HER, especially, the E b ̄ of the rear flag may increase by up to 30% than isolated flag. While for right triangular configurations, no HER is observed. The unsteady flow characteristics are further explored to reveal the mechanism of hydrodynamic coupling in system. The present study may shed some light on understanding the dynamics of this multi-flag system.
Cognitive Reserve and Related Constructs: A Unified Framework Across Cognitive and Brain Dimensions of Aging

Cognitive reserve and related constructs are valuable for aging-related research, but consistency and clarification of terms is needed as there is still no universally agreed upon nomenclature. We propose a new set of definitions for the concepts of reserve, maintenance, and resilience, and we invoke parallel concepts for each that are applicable to cognition and to brain. Our definitions of reserve and resilience correspond reasonably well to dictionary definitions of these terms. We demonstrate logical/methodological problems that arise from incongruence between commonly used conceptual and operational definitions. In our view, cognitive reserve should be defined conceptually as one’s total cognitive resources at a given point in time. IQ and education are examples of common operational definitions (often referred to as proxies) of cognitive reserve. Many researchers define cognitive reserve conceptually as a property that allows for performing better than expected cognitively in the face of aging or pathology. Performing better than expected is demonstrated statistically by interactions in which the moderator is typically IQ or education. The result is an irreconcilable situation in which cognitive reserve is both the moderator and the moderation effect itself. Our proposed nomenclature resolves this logical inconsistency by defining performing better than expected as cognitive resilience. Thus, in our usage, we would test the hypothesis that high cognitive reserve confers greater cognitive resilience. Operational definitions (so-called proxies) should not conflate factors that may influence reserve—such as occupational complexity or engagement in cognitive activities—with cognitive reserve itself. Because resources may be depleted with aging or pathology, one’s level of cognitive reserve may change over time and will be dependent on when assessment takes place. Therefore, in addition to cognitive reserve and cognitive resilience, we introduce maintenance of cognitive reserve as a parallel to brain maintenance. If, however, education is the measure of reserve in older adults, it precludes assessing change or maintenance of reserve. Finally, we discuss consideration of resistance as a subcategory of resilience, reverse causation, use of residual scores to assess performing better than expected given some adverse factor, and what constitutes high vs. low cognitive reserve across different studies.
Adverse Childhood Experiences, Mindfulness, and Grit in College Students in China

This study investigated the effect of ACEs and COVID-19 on grit and whether this effect is mediated by mindfulness. Although current scholarship has found that adverse childhood experiences (ACEs) have harmful consequences to individuals across the life span, less is known about the relationship between ACEs and grit. Grit is predictive of educational success and subjective wellbeing. A cross-sectional online survey administered to junior and senior students from 12 universities spread across China was conducted from September 20, 2020 to October 5, 2020. The universities were selected from geographically diverse regions of China to ensure a diverse sample. We received 1,871 completed responses from 2,229 invited students. The survey response rate was 83.9%. The results indicated that ACEs had significantly negative effects on grit, while mindfulness had significantly positive effects on grit. Once controlling for level of mindfulness, the effects of ACEs on grit largely reduced and became insignificant. The findings of this research indicate that mindfulness has a significant mediational effect on the relation between ACEs and grit and call for mindfulness-based interventions for enhancing grit for the population at risks.
Outcomes and CT Perfusion Thresholds of Mechanical Thrombectomy for Patients With Large Ischemic Core Lesions

Objective To explore the clinical prognosis and factors after mechanical thrombectomy (MT) in patients with large cerebral infarction assessed by computed tomographic perfusion (CTP)and the optimal threshold of cerebral blood flow (CBF) for estimating ischemic core. Methods We analyzed data from the anterior circulation database of our hospital (August 2018–June 2021). Multivariate logistic regression analyses identified the predictors of clinical outcomes for patients with large baseline infarcts (>50 ml) assessed by the MIStar software. The receiver operating characteristic (ROC) analysis was used to explore the cutoff value of factors. Results The present study included one hundred thirty-seven patients with large baseline infarcts. Moreover, 23 (16.8%) patients achieved functionally independent outcomes, and 50 (36.5%) patients died at 90 days. A total of 20 (14.7%) patients had symptomatic intracranial hemorrhage (sICH). The multivariable analysis showed that higher age and larger core volume were independent of poor outcomes. The cutoff value of core volume was 90 ml, and the age was 76 years. Hypertension and rt-PA treatment were independent factors of sICH. Higher age and larger ischemic volume were independent risk factors of mortality. Conclusions Mechanical thrombectomy can be applied in patients with large ischemic core volumes. Patients older than 76 years with large cores (>90 ml) are unlikely to benefit from MT. These findings may be helpful in selecting patients with large baseline infarcts to be treated by MT. The threshold of CBF < 30% is the independent factor, and this is worth evaluating in future studies to find the optimal threshold of CBF.
Association Between Physical Activity Intensity and the Risk for Depression Among Adults From the National Health and Nutrition Examination Survey 2007–2018

Objective Whether vigorous physical activities (VPA) bring additional benefits to depression prevention in comparison with moderate physical activity (MPA) remains unclear. The aim of this study was to find the correlation between the proportion of VPA to moderate-to-VPA (MVPA) (a combination of VPA and MPA) and the risk for depression, as well as to explore whether correlations differ among subgroups separated by age and sex. Methods The data originating from the National Health and Nutrition Examination Survey (NHANES) 2007–2018 were applied. The total amount of PA per week was obtained by multiplying frequency and duration. The proportion of VPA to MVPA was obtained among the participants who performed any MVPA. Depression was set for those who scored 10 and above in the Patient Health Questionnaire-9 (PHQ-9). The odds ratios (ORs) and 95% confidence intervals (95% CIs) for depression were evaluated using logistic regression. Results Among 26,849 participants of this study, only 12,939 adults were found with any MVPA, in which 748 participants with depression were detected. Logistic regression was conducted among 12,939 participants. The participants with higher than 66.7–100% of MVPA as VPA were inversely correlated with a 30% (OR = 0.70, 95% CI = 0.50, 0.99) lower risk for depression. The subgroup analyses revealed that significant correlations were only found in men and those aged 45 years and above. Conclusion This study suggested that a higher proportion of VPA to MVPA might be correlated with a lower risk for depression in men and those aged 45 years and above. Besides the recommendation, adults should perform 150 min MVPA per week, more time should be spent in performing VPA in MVPA among men and older adults.
Improving Suicide Prevention in Primary Care for Differing Levels of Behavioral Health Integration: A Review

Importance Suicide prevention implementation in primary care is needed due to the increasing rate of suicide in the past few decades, particularly for young and marginalized people. Primary care is the most likely point of contact for suicidal patients in the healthcare system. Attention to the level of medical integration with behavioral health is vital to suicide prevention and is applied throughout this review. Methods A narrative review was performed. Observations Many interventions help improve suicide prevention care. PCP education, screening, safety planning/lethal means reduction, care transitions, psychotherapy, and medication management are all evidence-based strategies. Additionally, the pragmatic topics of financing suicide prevention, supporting providers, enacting suicide postvention, and preparing for future directions in the field at each level of primary care/behavioral health integration are discussed. Conclusions and Relevance The findings are clinically relevant for practices interested in implementing evidence-based suicide prevention strategies by attending to the behavioral health/medical interface. Leveraging the patient/provider relationship to allow for optimal suicide prevention care requires clinics to structure provider time to allow for emotionally present care. Defining clear roles for staff and giving attention to provider well being are also critical factors to supporting primary care-based suicide prevention efforts.
Editorial: Human-Animal Interactions in Prehistoric China

Key Laboratory of Vertebrate Evolution and HumanOrigins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China, College of Earth and Planetary Sciences, University of Chinese Academy of Sciences, Beijing, China, Department of History and Philosophy, University of Alcalá de Henares, Alcalá de Henares, Spain, Key Laboratory of Western China’s Environmental Systems (Ministry of Education), College of Earth and Environmental Sciences, Lanzhou University, Lanzhou, China
Management of Natural Disaster and Its Influence on Economic–Environmental Performance: Fresh Evidence From BRICS

Previous literature documented the importance of natural disasters and their impact on economic performance, but it ignored the effects on the environment. This study examines the effect of natural disasters on the economic and environmental performance of BRICS economies over the period 1995–2019. This study applies panel autoregressive distributed lag (ARDL) and panel quantile regression approaches. The empirical findings show that natural disasters decrease economic growth but increase CO2 emissions. The findings of panel quantile regression display a significant negative impact of natural disasters on economic growth from the middle (30th) to higher (80th) quantiles. However, natural disasters significantly increase carbon emissions from the middle (50th) to higher (95th) quantiles. This study suggests the importance of proper planning for the management of natural disasters.