Miracle-dz/UniFAR-FTUs huggingface dataset:
Global Research Trends and Hotspots on Mitochondria in Acute Lung Injury from 2012–2021: A Bibliometric Analysis

Background: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a clinical syndrome associated with mitochondria and lacks effective preventive and therapeutic measures. This bibliometric study aims to gain insight into the scientific findings regarding mitochondria in ALI/ARDS. Methods: We retrieved the Science Citation Index Expanded (SCIE) of the Web of Science Core Collection (WoSCC) for mitochondria in ALI/ARDS publications from 2012–2021. VOSviewer, CiteSpace (5.8. R3) and Bibliometrix (3.1.4) R package were used for further analysis and visualization. Result: A total of 756 English-language articles and reviews were identified. The annual number of publications presented a rapidly developing trend. China was the most productive and cited country, and the USA had the greatest impact. In the keyword co-occurring network, the terms “acute lung injury”, “oxidative stress”, “inflammation”, “mitochondria” and “apoptosis” occurred most frequently. The co-citation network revealed that #1 mesenchymal stromal cell and #3 endothelial cell had the most bursts of citations. In addition, research hotspots have shifted from “potential therapeutic treatments” and “mitochondrial DNA (mtDNA)” to “endothelial cell” and “mesenchymal stromal cell (MSC)”. Conclusion: This bibliometric analysis reveals the research directions and frontier hotspots of mitochondria in ALI/ARDS, which has shown a rapid growth trend in annual publication numbers. mtDNA, mitophagy, and apoptosis have been the most active research areas, while studies on mitochondrial transfer in stem cells have become a hot topic in recent years.
A Capacitive DC-DC Boost Converter with Gate Bias Boosting and Dynamic Body Biasing for an RF Energy Harvesting System

In this paper, a fully integrated capacitive DC-DC boost converter for ultra-low-power internet of things (IoT) applications operating with RF energy harvesting is proposed. A DC-DC boost converter is needed to boost the low output voltage of the RF energy harvester to provide a high voltage to the load. However, a boost converter operating at a low voltage supplied by ambient RF energy harvesting has a problem in that power conversion efficiency is significantly lowered. The proposed on-chip capacitive DC-DC boost converter simultaneously applies gate bias boosting and dynamic body biasing techniques using only the internal boosted voltage without an additional circuit that increases power loss to boost the voltage, achieving high efficiency at an input voltage as low as 0.1 V. The designed capacitive boost converter achieves a peak power conversion efficiency (PCE) of 33.8% at a very low input voltage of 0.1 V, a 14% improvement over the peak PCE of the conventional cross-coupled charge pump. A maximum peak PCE of 80.1% is achieved at an input voltage of 200 mV and a load current of 3 μA. The proposed capacitive boost converter is implemented with a total flying capacitance of 60 pF, suitable for on-chip integration.
The Reciprocal Relationship Between Social Engagement and Cognitive Function Among Older Adults in South Korea

A greater number of studies have examined the impact of social engagement on cognitive function rather than the other way around, leaving their reciprocal association underexplored. Furthermore, formal and informal social engagement are not differentiated, although they may have independent relationships with cognitive function. This study aims to identify (1) whether informal and formal social engagements are effective in maintaining cognitive health and (2) if cognitive function has a bidirectional effect on social engagement. The study applies a dynamic panel data structural equation modeling with a maximum likelihood estimator (ML-SEM) to the Korean Longitudinal Study of Aging (KLoSA) data. The results confirm that frequent participation in organizational activities is more robustly associated with cognitive function than memberships or informal social contact. Concerning the bidirectional relationship, the cognitive function increases the degrees of informal and formal engagement. The study thus validates a reciprocal association between social engagement and cognitive function.
Recovery of qubit coherence by noise-eater technique

We propose a quantum noise eater for a single qubit and experimentally verify its performance for recovery of a superposition carried by a dual-rail photonic qubit. We consider a case when only one of the rails (e.g., one of interferometric arms) is vulnerable to noise. A coherent but randomly arriving photon penetrating into this single rail causes a change of its state, which results in an error in a subsequent quantum information processing. We theoretically prove and experimentally demonstrate a conditional full recovery of the superposition by this quantum noise eater.
METODY PŘEDZPRACOVÁNÍ OBRAZU PRO AUTOMATICKOU DETEKCI ÚČASTNÍKŮ SILNIČNÍHO PROVOZU

Hlavním cílem tohoto článku je provést analýzu metod předzpracování obrazu a uvést jednotlivé autory a publikace, které se jimi zabývají. Za účelem získání systematického přehledu je v článku navržena metodika pro vyhledávání jednotlivých relevantních zdrojů. Metody předzpracování obrazu předcházejí automatické detekci účastníků silničního provozu. Díky vhodně zvolenému postupu předzpracování obrazu je automatická detekce přesnější a rychlejší stejně jako následující klasifikace detekovaných objektů a jejich trasování. Vhodné předzpracování obrazu se využívá jak u standardní metody detekce odečítání pozadí, tak u moderních metod pracujících na principu neuronových sítí jako CNN, YOLO, SSD a další. Obsahem článku je přehled jednotlivých nejčastěji využívaných metod předzpracování obrazu a publikací, ve kterých je jednotliví autoři využívají pro přípravu obrazu před různými metodami automatické detekce. Následuje vyhodnocení výsledků a na závěr jsou navrženy směry dalšího výzkumu v této oblasti.
Innately expressed estrogen-related receptors in the skeletal muscle are indispensable for exercise fitness

Transcriptional determinants in the skeletal muscle that govern exercise capacity, while poorly defined, could provide molecular insights into how exercise improves fitness. Here, we have elucidated the role of nuclear receptors, estrogen‐related receptor alpha and gamma (ERRα/γ) in regulating myofibrillar composition, contractility, and exercise capacity in skeletal muscle. We used muscle‐specific single or double (DKO) ERRα/γ knockout mice to investigate the effect of ERRα/γ deletion on muscle and exercise parameters. Individual knockout of ERRα/γ did not have a significant impact on the skeletal muscle. On the other hand, DKO mice exhibit pale muscles compared to wild‐type (WT) littermates. RNA‐seq analysis revealed a predominant decrease in expression of genes linked to mitochondrial and oxidative metabolism in DKO versus WT muscles. DKO muscles exhibit marked repression of oxidative enzymatic capacity, as well as mitochondrial number and size compared to WT muscles. Mitochondrial function is also impaired in single myofibers isolated from DKO versus WT muscles. In addition, mutant muscles exhibit reduced angiogenic gene expression and decreased capillarity. Consequently, DKO mice have a significantly reduced exercise capacity, further reflected in poor fatigue resistance of DKO mice in in vivo contraction assays. These results show that ERRα and ERRγ together are a critical link between muscle aerobic capacity and exercise tolerance. The ERRα/γ mutant mice could be valuable for understanding the long‐term impact of impaired mitochondria and vascular supply on the pathogenesis of muscle‐linked disorders.
Global variation in nonstructural carbohydrate stores in response to climate

Woody plant species store nonstructural carbohydrates (NSCs) for many functions. While known to buffer against fluctuations in photosynthetic supply, such as at night, NSC stores are also thought to buffer against environmental extremes, such as drought or freezing temperatures by serving as either back‐up energy reserves or osmolytes. However, a clear picture of how NSCs are shaped by climate is still lacking. Here, we update and leverage a unique global database of seasonal NSC storage measurements to examine whether maximum total NSC stores and the amount of soluble sugars are associated with clinal patterns in low temperatures or aridity, indicating they may confer a benefit under freezing or drought conditions. We examine patterns using the average climate at each study site and the unique climatic conditions at the time and place in which the sample was taken. Altogether, our results support the idea that NSC stores act as critical osmolytes. Soluble Sugars increase with both colder and drier conditions in aboveground tissues, indicating they can plastically increase a plants' tolerance of cold or arid conditions. However, maximum total NSCs increased, rather than decreased, with average site temperature and had no relationship to average site aridity. This result suggests that the total amount of NSC a plant stores may be more strongly determined by its capacity to assimilate carbon than by environmental stress. Thus, NSCs are unlikely to serve as reservoir of energy. This study is the most comprehensive synthesis to date of global NSC variation in relation to climate and supports the idea that NSC stores likely serve as buffers against environmental stress. By clarifying their role in cold and drought tolerance, we improve our ability to predict plant response to environment.
Ambient surgery and tangential homotopy quaternionic projective spaces.

Introduction. In this paper the word manifold will always mean oriented compact C "-manifold. Unless otherwise specified, all homology and cohomology is taken with integral coefficients, and for Mn an n-manifold, [M] E Hn(M, AM) will denote the orientation class of M. A mapf: M-N between n-manifolds is of degree +1 iff*([M])=[N]. We denote the quaternions by Q, and quaternionic projective n-space, which may be described as the collection of quaternionic lines in Qn+1, by QPn. The underlying set of QPn can also be described as
Regulation of K+-Dependent Na+/Ca2+-Exchangers (NCKX)

Potassium-dependent sodium-calcium exchangers (NCKX) have emerged as key determinants of calcium (Ca2+) signaling and homeostasis, especially in environments where ion concentrations undergo large changes, such as excitatory cells and transport epithelia. The regulation of NCKX transporters enables them to respond to the changing cellular environment thereby helping to shape the extent and kinetics of Ca2+ signals. This review examines the current knowledge of the different ways in which NCKX activity can be modulated. These include (i) cellular and dynamic subcellular location (ii); changes in protein expression mediated at the gene, transcript, or protein level (iii); genetic changes resulting in altered protein structure or expression (iv); regulation via changes in substrate concentration (v); and post-translational modification, partner protein interactions, and allosteric regulation. Detailed mechanistic understanding of NCKX regulation is an emerging area of research with the potential to provide important new insights into transporter function, the control of Ca2+ signals, and possible interventions for dysregulated Ca2+ homeostasis.
Identification of robust untestable path delay faults

This paper presents a theoretical analysis to identify robust untestable path delay faults. It first classifies the path reconvergence of fanouts into seven cases and deduces the necessary conditions to robustly test path delay faults for each case. It then proposes a procedure, based on the deduced conditions, to identify the robust untestable path delay faults. The procedure was applied to ISCAS 85' circuits and it was found that the robust untestable faults occupy a high percentage of the total path delay faults. In addition, it also presents a method to estimate the number of robust untestable path delay faults for a circuit.
Pathogen Exposure in White Whales (Delphinapterus leucas) in Svalbard, Norway

The Svalbard white whale (Delphinapterus leucas) population is one of the smallest in the world, making it particularly vulnerable to challenges such as climate change and pathogens. In this study, serum samples from live captured (2001–2016) white whales from this region were investigated for influenza A virus (IAV) antibodies (Abs) (n = 27) and RNA (n = 25); morbillivirus (MV) Abs (n = 3) and RNA (n = 25); Brucella spp. Abs; and Toxoplasma gondii Abs (n = 27). IAV Abs were found in a single adult male that was captured in Van Mijenfjorden in 2001, although no IAV RNA was detected. Brucella spp. Abs were found in 59% of the sample group (16/27). All MV and T. gondii results were negative. The results show that Svalbard white whales have been exposed to IAV and Brucella spp. , although evidence of disease is lacking. However, dramatic changes in climate and marine ecosystems are taking place in the Arctic, so surveillance of health parameters, including pathogens, is critical for tracking changes in the status of this vulnerable population.
The radio counterpart of the hard X-ray source GRS 1758-258

GRS 1758-258 and 1E 1740.7-2942 are two persistent hard X-ray sources in a region of about 100 deg 2 around the Galactic center. The Galactic center annihilator, 1E 1740.7-2942, has recently been found to be associated with a compact radio source from which a double radio jet emanates.In this Letter we report the results of a deep 6 cm VLA mapping of the field around the GRS 1758-258 X-ray position. Our observations reveal, as in 1E 1740.7-2942, the presence of another triple radio source, whose central component is time variable and falls inside the error circle (10″ of radius) of ROSAT
A Review on : Plant Based Antioxidant

Plants produce a lot of antioxidants to control the oxidative stress caused by sunbeams and oxygen, they can represent a source of new compounds with antioxidant activity.Antioxidants are the group of neutraceuical parameters which works on regulate the prevent oxidative damage of body cause due to free radicals. Natural antioxidants play an important role scavenge harmful free radicals from our body obtained naturally from plants . they are present in various parts of plants as Ascorbic acid , vitamin E , and phenolic compounds . Antioxidants exert their mode of action by suppressing the formation of reactive oxygen species either by inhibition of enzymes or by chelating trace elements. Free radicals are the chemical species that have an unpaired electron and play very important role in human health and beneficial in combating against several diseases like cardiovascular disorders, lung damage, inflammation etc. These can damage cell membranes and other vital cell components, such as genetic material in the cell nucleus, and can inactivate enzymes. Damage to body cells and molecules by oxygen containing free radicals has been implicated in a wide variety of diseases. DPPH is widely used to evaluate the free radical scavenging effect of natural antioxidant. Antioxidants in different parts of plants such as ascorbic acid, vitamin E and phenolic compounds possess the ability to reduce the oxidative damage associated with many diseases including cancer, cardiovascular diseases, cataracts, atherosclerosis, diabetes, arthritis, immune deficiency diseases and ageing.
Comparison of intravitreal bevacizumab and ranibizumab used for myopic choroidal neovascularization

Background: To evaluate the effect of intravitreal bevacizumab (IVB) and ranibizumab (IVR) for the treatment of choroidal neovascularization (CNV) secondary to pathologic myopia (PM) by meta-analysis. Methods: Pertinent publications of randomized controlled trials (RCTs) were identified through systemic searches of PubMed, EMBASE, Web of science, Cochrane Library, clinicaltrials.gov, CNKI, CQVIP, and Wanfang database. All comparative studies of IVB or IVR as treatment for CNV secondary to pathologic myopia were included. Meta-analysis of these RCTs was performed using Review Manager 5.3 software. The &khgr;2 test and I2 values were used to analyze heterogeneity. Measurements included best-corrected visual acuity (BCVA) and central foveal thickness (CFT). Results: A total of 3 randomized controlled clinical trials involving 158 eyes were included, 81 eyes in IVB group and 77 eyes in IVR group. Compared with baseline, at 1, 3, 6, and 12 months after IVB or IVR treatment, BCVA was significantly increased. Change of BCVA at 1, 3, 6, and 12 months did not vary significantly between IVB and IVR group (1 month: Z = 0.30, 95% CI = −0.08 to 0.11, P = .76; 3 months: Z = 0.36, 95% CI = −0.10 to 0.15, P = .72; 6 months: Z = 0.17, 95% CI = −0.10 to 0.12, P = .86; 12 months: Z = 0.64, 95% CI = −0.15 to 0.08, P = .52). Conclusion: Both IVR and IVB can significantly improve BCVA of eyes with mCNV, but there was no significant difference between the 2 therapies on the treatment of mCNV.
Increasing Stress to Induce Apoptosis in Pancreatic Cancer via the Unfolded Protein Response (UPR)

High rates of cell proliferation and protein synthesis in pancreatic cancer are among many factors leading to endoplasmic reticulum (ER) stress. To restore cellular homeostasis, the unfolded protein response (UPR) activates as an adaptive mechanism through either the IRE1α, PERK, or ATF6 pathways to reduce the translational load and process unfolded proteins, thus enabling tumor cells to proliferate. Under severe and prolonged ER stress, however, the UPR may promote adaptation, senescence, or apoptosis under these same pathways if homeostasis is not restored. In this review, we present evidence that high levels of ER stress and UPR activation are present in pancreatic cancer. We detail the mechanisms by which compounds activate one or many of the three arms of the UPR and effectuate downstream apoptosis and examine available data on the pre-clinical and clinical-phase ER stress inducers with the potential for anti-tumor efficacy in pancreatic cancer. Finally, we hypothesize a potential new approach to targeting pancreatic cancer by increasing levels of ER stress and UPR activation to incite apoptotic cell death.
The design of random surfaces that produce nonstandard refraction of light

On the basis of the geometrical optics limit of the Kirchhoff approximation we design a one-dimensional random interface between two dielectric media that refracts p- or s-polarized light incident on it at an arbitrary angle of incidence θ0 from one of them into the other at an arbitrary but specified angle of transmission θt that is not defined in terms of θ0 by Snell's law. We call such transmission nonstandard refraction.
Chasma Boreale, Mars: A Sapping and Outflow Channel with a Tectono-thermal Origin

Abstract A detailed geomorphological study of Chasma Boreale, a widely known feature of Mars' north polar cap, has been carried out for the first time, along with a quantitative paleohydrological model. It is concluded that the chasma was eroded by a flow whose discharge was on the order of magnitude of 10 9 m sec −1 . This catastrophic flow is thought to have been preceded by a powerful sapping process, caused by a tectonically focused thermal event. Several lines of evidence indicate tectonic control in the distribution and present aspect of most of the polar troughs. This tectonic forcing probably played a major role in the inception of not only Chasma Boreale but also other polar reentrants as well.
How Inflation Varies Across Spanish Households

Inflation has distributional effects. Leveraging data on consumption expenditure of goods across households provided in the Spanish Household Budget Survey we estimate household-specific inflation from 2006 to 2021 in Spain and analyse how it varies according to households’ known characteristics. We show that households with lower income, more members and whose head is less educated, older, and male experience higher inflation. Finally, we also depict the effects of the most recent price increases across households.
Prebrajanje razapinjućih stabala grafa

Ovaj se članak bavi tehnikama za prebrojavanje razapinjućih stabala grafa. Predstavljen je Kirchoffov matrični teorem o stablima koji povezuje broj razapinjućih stabala grafa i determinantu matrice čije vrijednosti ovise o grafu. Primjenom teorema izračunat je broj razapinućih stabala od potpunog grafa Kn, potpunog bipartitnog grafa Krs i grafa kotača Wn.
Strategies of Macrophages to Maintain Bone Homeostasis and Promote Bone Repair: A Narrative Review

Bone homeostasis (a healthy bone mass) is regulated by maintaining a delicate balance between bone resorption and bone formation. The regulation of physiological bone remodeling by a complex system that involves multiple cells in the skeleton is closely related to bone homeostasis. Loss of bone mass or repair of bone is always accompanied by changes in bone homeostasis. However, due to the complexity of bone homeostasis, we are currently unable to identify all the mechanisms that affect bone homeostasis. To date, bone macrophages have been considered a third cellular component in addition to osteogenic spectrum cells and osteoclasts. As confirmed by co-culture models or in vivo experiments, polarized or unpolarized macrophages interact with multiple components within the bone to ensure bone homeostasis. Different macrophage phenotypes are prone to resorption and formation of bone differently. This review comprehensively summarizes the mechanisms by which macrophages regulate bone homeostasis and concludes that macrophages can control bone homeostasis from osteoclasts, mesenchymal cells, osteoblasts, osteocytes, and the blood/vasculature system. The elaboration of these mechanisms in this narrative review facilitates the development of macrophage-based strategies for the treatment of bone metabolic diseases and bone defects.
The Performance of Supervised Machine Learning Based Relay Selection in Cooperative NOMA

This paper aims to exploit the benefits of supervised machine learning algorithms in resolving joint relay selection and non-orthogonal multiple access (NOMA) transmission in cooperative networks. Both relay selection and NOMA are capable to increase the system throughput. The optimization of the joint mixed-integer relay selection under the NOMA transmission problem is hard to be solved for achieving the global maximum of the system throughput. To simplify this complexity, supervised and unsupervised machine learning algorithms have a strong profile in dealing with hard optimization problems. The supervised learning algorithms have shown promising results in relay selection, and one of the widely applied supervised learning algorithms is the support vector machine (SVM). Therefore, in this paper, relay selection is approached as an SVM multi-class classification problem. The main concept of the SVM classification algorithm is to optimize the parameters of the SVM classifiers by training the classifiers with a large set of system realizations. The major advantage of this method is that the training stage can be performed offline as the optimizing of the SVM classifiers parameters requires high processing power, then the trained SVM multi-class classifiers can be used directly with no more training required during the system operation. Simulation results validate that the performance of the proposed supervised learning-based scheme is close to that of the global optimum exhaustive search relay selection scheme and outperforms the other available schemes. In addition, the proposed scheme is considerably simpler than the exhaustive search scheme, primarily when the number of relays is large.