Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety of Prasugrel loading in ruptured blister like aneurysm treated with a Pipeline device

introDuCtion: Blister like aneurysm (BLA) typically occurs at non-branching sites and is commonly located at the dorsal supraclinoid internal carotid artery (ICA). 1 Morphologically, they resemble a blood blister and their characteristic geometry is that of a broad base with a small aspect ratio. Histopathologically, they differ from saccular aneurysms in that they lack the intima and media and are considered to be dissecting in etiology.2 Diagnosis can be challenging and three-dimensional rotational angiography appears to be the gold standard in detecting these aneurysms.3 BLA account for approximately 0.5 to 2% of all ruptured aneurysms.4 Natural history of BLA appear to be aggressive in that they tend to grow and rebleed; in patients managed conservatively from the outset, 20% died predominantly due to rebleed and in a further 68% growth of the aneurysm or repeat bleed necessitated treatment.4 Frequent rebleeding and/or regrowth of the dome after the neck clipping was observed by Satoh et al5. The friable nature of BLA and their complex geometry pose unique challenge to both surgical and endovascular management. In a systematic review, combined surgical morbidity and mortality amounted to 37.8%. 6 Endovascular methods to treat BLA could be either deconstructive or reconstructive. Parent artery occlusion (PAO) following balloon test occlusion has been undertaken and is very effective in achieving immediate aneurysm occlusion. However, the downside are that of occlusion of side branches and consequent negative impact on vasospasm due to reduced perfusion pressure, and lack of access to perform intra-arterial therapy.7 Additionally, these aneurysms do not appear to be suitable for conventional coiling and the reported combined morbidity and mortality was high (34%). A variety of reconstructive techniques have been described to treat BLA. The combined morbidity and mortality was low with stent assisted coiling and overlapping stent placement, and was 10 and 5.5% respectively. The key drawback were that of regrowth (38%) and rebleed (11%). 6 Therefore, the concept of endoluminal reconstruction rather than endosaccular occlusion is most appealing to treat BLA and recently flow diverters (FDs) are being increasingly used to treat these aneurysms. Emerging data indicate that mid to long-term aneurysm occlusion rates are better and the need for repeat treatment lower with flow diversion.8,9 Received: 26 June 2017 Accepted: 28 February 2018 Revised: 15 February 2018 © 2018 The Authors. Published by the British Institute of Radiology
Process‐dependent residual trapping of CO2 in sandstone

This paper demonstrates that the nature and extent of residual CO2 trapping depend on the process by which the CO2 phase is introduced into the rock. We compare residual trapping of CO2 in Berea Sandstone by imbibing water into a core containing either exsolved CO2 or CO2 introduced by drainage. X‐ray computed tomography measurements are used to map the spatial distribution of CO2 preimbibition and postimbibition. Unlike during drainage where the CO2 distribution is strongly influenced by the heterogeneity of the rock, the distribution of exsolved CO2 is comparatively uniform. Postimbibition, the CO2 distribution retained the essential features for both the exsolved and drainage cases, but twice as much residual trapping is observed for exsolved CO2 even with similar preimbibition gas saturations. Residually trapped exsolved gas also disproportionately reduced water relative permeability. Development of process‐dependent parameterization will help better manage subsurface flow processes and unlock benefits from gas exsolution.
Environmental Reviews and Case Studies: The Town's Abuzz: Collaborative Opportunities for Environmental Professionals in the Slow City Movement

The global Slow Movement, a response to negative effects of speed on everyday life, seeks to reconnect people and their social and ecological environments. Slow Food and Cittaslow (Slow Cities) are allied Slow Movement networks operating in over 150 countries, including the United States (US). These two networks involve the interrelationship of numerous place-based factors important to social-ecological resilience: local and regional food markets, recovery and protection of biodiversity and local ecologies, support for cultural traditions, agricultural policy reform, climate adaptation planning, economic development, social inclusion, quality of life in the built environment, and the politics of land development. This article presents the philosophical underpinnings of Slow Food and the associated membership requirements of Cittaslow by using the example of Sonoma Valley, California, the first certified Cittaslow in the US (2009). The article then describes Sonoma Valley's Cittaslow Pollinator Stewardship Collaborative to show how the nascent organization has begun its work by facilitating the participation of environmental professionals in community life. In its first year, Cittaslow Sonoma Valley has used a combination of pleasure and responsibility to increase both the visibility of environmental concerns and the opportunities for diverse residents to act locally and globally on issues integrating environmental and economic support. Because it offers a different approach to environmental responsibility, the Slow Movement may be of particular interest to environmental professionals who are concerned about societal response to the complexity and uncertainty of global environmental change.
The onset of the southwest monsoon over Kerala: 1901–1980

Utilising daily mean rainfall from dense rain gauge networks, the dates of onset of the southwest monsoon over south and north Kerala have been derived on the basis of objective criteria for the years 1901 to 1980. These dates have been compared with the onset dates as per records of the India Meteorological Department. Statistics of the onset dates are presented. The mean onset date for south Kerala is found to be 30 May and for north Kerala 1 June with a standard deviation of about 9 days in both cases. The sharp increase in rainfall that heralds the onset of the monsoon is highlighted by superposed epoch analysis. The prevailing notion that rainfall from pre-monsoon thunderstorms progressively increases and merges with the monsoon rainfall is shown to be not valid.
Mechanisms of desensitization to a PDE inhibitor (milrinone) in conscious dogs with heart failure

Vatner. Mechanisms of desensitization to a PDE inhibitor (milrinone) in conscious dogs with heart failure. Am. J. Physiol. 276 ( Heart Circ. Physiol. 45): H1699–H1705, 1999. — The goal of this study was to determine the extent to which the effects of milrinone were desensitized in heart failure (HF) and to determine the mechanisms, i.e., whether these effects could be ascribed to changes in cAMP or phosphodiesterase (PDE) activity in HF. Accordingly, we examined the effects of milrinone in seven conscious dogs before and after HF was induced by rapid ventricular pacing at 240 beats/min. The dogs were chronically instrumented for measurements of left ventricular (LV) pressure and ﬁrst derivative of LV pressure (dP/d t ), arterial pressure, LV internal diameter, and wall thickness. Milrinone (10 µg·kg 2 1 ·min 2 1 iv) increased LV dP/d t by 1,854 6 157 from 2,701 6 105 mmHg/s ( P , 0.05) before HF. After HF the increase in LV dP/d t in response to milrinone was attenuated signiﬁcantly ( P , 0.05); it increased by 615 6 67 from 1,550 6 107 mmHg/s, indicating marked desensitization. In the presence of ganglionic blockade the increases in LV dP/d t ( 1 445 6 65 mmHg/s) in response to milrinone were markedly less ( P , 0.01), and milrinone increased LV dP/d t even less in HF ( 1 240 6 65 mmHg/s). cAMP and PDE activity were measured in endocardial and epicardial layers in normal and failing myocardium. cAMP was decreased signiﬁcantly ( P , 0.05) in LV endocardium ( 2 26%) but not signiﬁcantly in LV epicardium ( 2 14%). PDE activity was also decreased signiﬁcantly ( P , 0.05) in LV endocardium ( 2 18%) but not in LV epicardium ( 2 4%). Thus signiﬁcant desensitization to milrinone was observed in conscious dogs with HF. The major effect was autonomically mediated. The biochemical mechanism appears to be due in part to the modest reductions in PDE activity in failing myocardium, which, in turn, may be a compensatory mechanism to maintain cAMP levels in HF. Reductions in cAMP and PDE levels were restricted to the subendocardium, suggest-ing that the increased wall stress and reduced coronary reserve play a role in mediating these changes.
Ondansetron Reverses Antihypersensitivity from Clonidine in Rats after Peripheral Nerve Injury Role of (cid:1) -Aminobutyric Acid in (cid:2) 2-Adrenoceptor and 5-HT3 Serotonin Receptor Analgesia

Introduction: Monoaminergic pathways, impinging an (cid:2) 2-adrenoceptors and 5-HT3 serotonin receptors, modulate nociceptive transmission, but their mechanisms and interactions after neuropathic injury are unknown. Here we examine these interactions in rodents after nerve injury. Methods: Male Sprague-Dawley rats following L5–L6 spinal nerve ligation (SNL) were used for either behavioral test-ing, in vivo microdialysis for (cid:1) -aminobutyric acid (GABA) and acetylcholine release, or synaptosome preparation for GABA release. Results: Intrathecal administration of the (cid:2) 2-adrenoceptor agonist (clonidine) and 5-HT3 receptor agonist (chlorophe-nylbiguanide) reduced hypersensitivity in SNL rats via GABA receptor-mediated mechanisms. Clonidine increased GABA and acetylcholine release in vivo in the spinal cord of SNL rats but not in normal rats. Clonidine-induced spinal GABA release in SNL rats was blocked by (cid:2) 2-adrenergic and nicotinic cholinergic antagonists. The 5-HT3 receptor antagonist ondansetron decreased and chlorophenylbiguanide increased spinal GABA release in both normal and SNL rats. In synaptosomes from the spinal dorsal horn of SNL rats,
A study of some glauconites from cretaceous and tertiary formations in South-East England

Abstract A study of soil formation on glauconitic parent materials in South-East England has included a mineralogical investigation of glauconite grains, heretofore identified solely by morphology. The grains have been subjected to X-ray diffraction, differential thermal and partial chemical analyses, and have been found to consist essentially of randomly interstratified micaceous and montmorillonitic clay mineral; thus all are glauconite sensu lato. Only small amounts of non-clay mineral impurities have been detected. The proportion of expandable layer material has been found to be related to the % K2O and cation exchange capacity of the specimens.
Koalas in the land of the pandas: reviewing Australian expatriates’ China preparation

The unprecedented internationalization of organizations in the past two decades has made the need for cross-cultural awareness, appreciation and understanding in the daily operations of international businesses increasingly prevalent. In both academic circles and the popular press much has been written about the need for individuals to be cross-culturally sensitive, adaptive and responsive when managing across national borders. One of the key aspects identified in literature as contributing towards achieving cross-cultural sensitivity of expatriates is correct selection, pre-departure and post-arrival training and in situ support for the expatriate and his/her family. The research presented in this paper examines the selection, training and support of Australian expatriates in China, a nation that has loomed large in the current and future trading and expansion plans of many Australian corporations since it opened its doors to international commerce in the late 1970 s. Based on information gathered through semi-structured interviews conducted with expatriate Australians in Shanghai in 1999 and 2001, the results of this research indicate that, while organizations are recognizing the need to employ Australians who have prior China knowledge, organizational preparation remains negligible.
Gabapentin premedication for postoperative analgesia and emergence agitation after sevoflurane anesthesia in pediatric patients Pediyatrik hastalarda ameliyat sonrasi analjezi ve sevofluran anestezisi sonrasi derlenme ajitasyonu için gabapentin premedikasyonu

Summary Objectives: The aim of this study was to investigate the effect of gabapentin premedication on postoperative 24th hour total analgesic consumption and the incidence of emergence agitation after sevoflurane based anesthesia in pediatric patients undergoingtonsillectomyandadenoidectomy. Methods: 46 healthy, ASA class I or II, aged 3-12 year old children were included into the study. The patients were randomly assigned to one of the control (Group C) or gabapentin group (Group G) consisting of 23 patients in each. Group C received 10 ml of saline, Group G received gabapentin 15 mg.kg -1 dissolved in 10 ml of saline orally 30 min. before the induction of anesthesia. After anesthesia induction with 8% sevoflurane in 50% O 2 -N 2 O. General anesthesia was maintained with 1 MAC sevoflurane in 50% O 2 -N 2 O. Emergence agitation was assessed with a 5 point scale and recorded every 10 min. of first 30 min. of the postoperative period. Parents were contacted 24 hours after the surgery to evaluate pain, total analgesic consumption, parent satisfactionandanysideeffect. Results: Agitation scores were significantly lower in group G compared to group C in the postoperative 20th and 30th minutes (p<0.01, 0.05 respectively). Total analgesic requirement in postoperative 24 hour was significantly lower in group G (p<0.01). Satisfaction scores of parents was also higher in group G (p<0.05). Conclusion: Gabapentin premedication decreases postoperative 24th hour analgesic consumption and attenuates emergence agitation after sevoflurane anesthesia.
Geometry and evolution of low‐angle normal faults (LANF) within a Cenozoic high‐angle rift system, Thailand: Implications for sedimentology and the mechanisms of LANF development

At least eight examples of large (5–35 km heave), low‐angle normal faults (LANFs, 20°–30° dip) occur in the Cenozoic rift basins of Thailand and laterally pass into high‐angle extensional fault systems. Three large‐displacement LANFs are found in late Oligocene–Miocene onshore rift basins (Suphan Buri, Phitsanulok, and Chiang Mai basins), they have (1) developed contemporaneous with, or after the onset of, high‐angle extension, (2) acted as paths for magma and associated fluids, and (3) impacted sedimentation patterns. Displacement on low‐angle faults appears to be episodic, marked by onset of lacustrine conditions followed by axial progradation of deltaic systems that infilled the lakes during periods of low or no displacement. The Chiang Mai LANF is a low‐angle (15°–25°), high‐displacement (15–35 km heave), ESE dipping LANF immediately east of the late early Miocene Doi Inthanon and Doi Suthep metamorphic core complexes. Early Cenozoic transpressional crustal thickening followed by the northward motion of India coupled with Burma relative to east Burma and Thailand (∼40–30 Ma) caused migmatization and gneiss dome uplift in the late Oligocene of the core complex region, followed by LANF activity. LANF displacement lasted 4–6 Ma during the early Miocene and possibly transported a late Oligocene–early Miocene high‐angle rift system 35 km east. Other LANFs in Thailand have lower displacements and no associated metamorphic core complexes. The three LANFs were initiated as low‐angle faults, not by isostatic rotation of high‐angle faults. The low‐angle dips appear to follow preexisting low‐angle fabrics (thrusts, shear zones, and other low‐angle ductile foliations) predominantly developed during Late Paleozoic and early Paleogene episodes of thrusting and folding.
An exact solution for the gravity curvature (Bullard B) correction

The complete Bouguer reduction includes, in addition to the simple Bouguer slab correction (Bullard A), both curvature (Bullard B) and terrain (Bullard C) corrections. A new closed‐form formula for the curvature correction is derived for which the calculated values differ from those published by Swick by more than 0.5 mGal for high elevations. These corrections reduce those of an infinite slab (Bullard A) to that of a spherical cap having a surface radius of 166.7 km. The spherical cap produces a lesser effect than the infinite slab because of the “truncation” of that part of the slab above the earth and extending to infinity, but it produces a greater effect than the slab because of subslab earth resulting from curvature. The physical significance of the correction lies in the combination of these two differences, which are each a function of elevation. The Bullard B surface radius (166.7 km: outer radius of the Hayford‐Bowie system) is reaffirmed by the exact formula to be appropriate for exploration su.
Az N-terminális pro-B natriureticus peptid mérésének korai ismétlése akut szívelégtelenség miatt hospitalizált betegeken

Bevezetés: A szívelégtelenség gyanúja miatt hospitalizált szívelégtelen betegeknél a natriureticus peptidek meghatáro-zása mind a diagnózis megerősítése, mind pedig a prognosztika szempontjából fontos. A kezelés hatására jelentkező natriureticuspeptidszint-változás mértéke a prognózis egyik meghatározója. Célkitűzés: Annak eldöntése, hogy az akut szívelégtelenség miatt felvett betegeknél a felvételi natriureticus peptid korai ismétlése eredményez-e olyan változást, amely befolyásolhatja a diagnózist és a prognózist. Módszer: Prospektív adatgyűjtés a 2017 és 2018 között a Budai Irgalmasrendi Kórház Kardiológia osztályán kezelt akut szívelégtelen betegekre vonatkozóan, az N-terminális pro-B natriureticus peptid (NT-proBNP) szintjének a felvételkor és 12 órán belül ismételten mért értékeinek összehasonlítására. Azon betegek adatait elemeztük, akiknek a felvételt indokoló panaszai 24 órán belül kezdődtek, és a panaszokat szívelégtelenség okozta. Eredmények: A vizsgált 23 beteg átlagéletkora 77,9 ± 8,3 év volt. A betegek nagy részénél a szívelégtelenséget csökkent szisztolés balkamra-funkciót okozta. Ezen betegeknél az ejekciós frakció 34,1 ± 3,9%-nak adódott. A panasz kezdetétől eltelt idő 6,7 óra ± 2,2 óra volt, míg az ismételt biomarkermeghatározásig eltelt idő 6,5 ± 2,2 órát tett ki a felvételi mérés időpontjához képest. Az NT-proBNP medián értéke 5064 pg/ml-ről 8847 pg/ml-re emelkedett (p<0,0005) a 6 órás kontroll során, ami 75%-os növekedést jelentett. A hs-troponin-T átlaga 46 ± 25 ng/l-ről 78 ± 51 ng/l-re növekedett (p<0,002). Következtetések: Akut szívelégtelenségben jelentős NT-proBNP-emelkedés várható a felvételt követő korai, ismételt mérés eredményeként. Ennek ismerete mind diagnosztikai, mind prognosztikai szempontból jelentőséggel bírhat. A megfigyelésnek nagyszámú betegen való validálása szükséges. akut szívelégtelenség, Conclusions: A significant increase in NT-proBNP levels is to be expected in early repeated measurement after hospi-tal admission. This fact could have diagnostic and prognostic consequences if validated in a larger patient population.
Development of a New Asymmetric Anchor Plate for Prefabricated Vertical Drain Installation via Centrifuge Model Tests

AbstractThis study investigates the kinematic behavior of a clay-mandrel-anchor system during the driving-retrieval process and its influence on the installation of prefabricated vertical drains and clay disturbance. In addition, a new anchor plate with an asymmetric shape is proposed as an alternative for improved anchoring performance and clay disturbance mitigation. To investigate the behavior of the clay-mandrel-anchor system, two-dimensional centrifuge model tests were developed and successfully performed to visualize anchoring kinematics and deformation of the clay layer. The tests demonstrated that the asymmetric anchor plate effectively provides an anchoring mechanism and reduces the degree of disturbance. The conventional anchor has potential risk of delayed anchoring and thus unsuccessful installation. While the amount and extent of clay deformation are obviously affected by the protruding length of the anchor plates into the clay, the protrusion length has less influence on the range of the sme.
Use of AIS Data to Characterise Marine Traffic Patterns and Ship Collision Risk off the Coast of Portugal

This paper studies the risk of ship collision off the coast of Portugal based on Automatic Identification System (AIS) data, which is recorded and maintained by the Portuguese coastal Vessel Traffic Service (VTS) control centre (CCTMC). Computer programs for decoding, visualization and analysis of the AIS data have been developed. From analysis of the AIS data available, maritime traffic off the coast of Portugal is characterized and a statistical analysis of traffic in the Traffic Separation Schemes is provided. An algorithm has been developed to assess the risk profile and the relative importance of routes associated with ports. A method is proposed to calculate the collision risk from the assessment of the number of collision candidates by estimating future distances between ships based on their previous positions, courses and speeds, and comparing those distances with a defined collision diameter. Values of causation probability suggested in several studies are used to calculate the expected number of collisions in the period of time under investigation based on the number of collision candidates. The results of this study are then compared with the number of collisions that have occurred between 1997–2006, registered and maintained by the Portuguese Maritime Authority.
Characterizing hydrophobicity of interfaces by using cavity formation, solute binding, and water correlations

Hydrophobicity is often characterized macroscopically by the droplet contact angle. Molecular signatures of hydrophobicity have, however, remained elusive. Successful theories predict a drying transition leading to a vapor-like region near large hard-sphere solutes and interfaces. Adding attractions wets the interface with local density increasing with attractions. Here we present extensive molecular simulation studies of hydration of realistic surfaces with a wide range of chemistries from hydrophobic (−CF3, −CH3) to hydrophilic (−OH, −CONH2). We show that the water density near weakly attractive hydrophobic surfaces (e.g., −CF3) can be bulk-like or larger, and provides a poor quantification of surface hydrophobicity. In contrast, the probability of cavity formation or the free energy of binding of hydrophobic solutes to interfaces correlates quantitatively with the macroscopic wetting properties and serves as an excellent signature of hydrophobicity. Specifically, the probability of cavity formation is enhanced in the vicinity of hydrophobic surfaces, and water–water correlations correspondingly display characteristics similar to those near a vapor–liquid interface. Hydrophilic surfaces suppress cavity formation and reduce the water–water correlation length. Our results suggest a potentially robust approach for characterizing hydrophobicity of more complex and heterogeneous surfaces of proteins and biomolecules, and other nanoscopic objects.