Miracle-dz/UniFAR-FTUs huggingface dataset:
New Quinoline–Urea–Benzothiazole Hybrids as Promising Antitubercular Agents: Synthesis, In Vitro Antitubercular Activity, Cytotoxicity Studies, and In Silico ADME Profiling

A series of 25 new benzothiazole–urea–quinoline hybrid compounds were synthesized successfully via a three-step synthetic sequence involving an amidation coupling reaction as a critical step. The structures of the synthesized compounds were confirmed by routine spectroscopic tools (1H and 13C NMR and IR) and by mass spectrometry (HRMS). In vitro evaluation of these hybrid compounds for their antitubercular inhibitory activity against the Mycobacterium tuberculosis H37Rv pMSp12::GPF bioreporter strain was undertaken. Of the 25 tested compounds, 17 exhibited promising anti-TB activities of less than 62.5 µM (MIC90). Specifically, 13 compounds (6b, 6g, 6i–j, 6l, 6o–p, 6r–t, and 6x–y) showed promising activity with MIC90 values in the range of 1–10 µM, while compound 6u, being the most active, exhibited sub-micromolar activity (0.968 µM) in the CAS assay. In addition, minimal cytotoxicity against the HepG2 cell line (cell viability above 75%) in 11 of the 17 compounds, at their respective MIC90 concentrations, was observed, with 6u exhibiting 100% cell viability. The hybridization of the quinoline, urea, and benzothiazole scaffolds demonstrated a synergistic relationship because the activities of resultant hybrids were vastly improved compared to the individual entities. In silico ADME predictions showed that the majority of these compounds have drug-like properties and are less likely to potentially cause cardiotoxicity (QPlogHERG > −5). The results obtained in this study indicate that the majority of the synthesized compounds could serve as valuable starting points for future optimizations as new antimycobacterial agents.
Dermatoglifia, somatotipo e composição corporal no beach handball: Estudo comparativo entre diferentes níveis de qualificação esportiva Dermatoglyph, somatotype and body composition in beach handball: Comparative study among different level of sportive qualification

The aim of this study was to compare the dermatoglyph, somatotype and body composition at different level of qualification of Brazilian women's beach handball. This study was transversal, descriptive and comparative character. The sample consisted of n=32 athletes; (n=10) high performance (bi-champion of the world); (n=11) intermediary performance (compete national championships) and (n = 11) low performance (compete neighborhood tournaments and/or at most municipal). Was used the mean, standard deviation, minimum, maximum, MANOVA, one-way ANOVA, Kruskal-Wallis test, and Scheffe's post hoc test, significance level of p . 05) for: A, L, W, D10, SQTL D10, SQTL e IMC, but difference to % G. There was a higher incidence of loop (L) and the formulas L>W, ALW, W> L, AL. The groups presented on average BMI eutrophic, with high, intermediary and low performance, presenting respectively 22.74 kg/m², 23.70 kg/m² and 22.01 kg/m² with G% above values for the beach handball. The Somatotype was mesomorphic endomorph for all groups. Although the velocity has been the physical quality with greater genetic predisposition (high, intermediary and low performance respectively 71.0%, 54.0%, 83.0%), the sportive qualification was characterized by coordination, endurance, velocity and explosive strength, with high performance presenting better values than the others.
The Functional Interplay between Ethylene, Hydrogen Sulfide, and Sulfur in Plant Heat Stress Tolerance

Plants encounter several abiotic stresses, among which heat stress is gaining paramount attention because of the changing climatic conditions. Severe heat stress conspicuously reduces crop productivity through changes in metabolic processes and in growth and development. Ethylene and hydrogen sulfide (H2S) are signaling molecules involved in defense against heat stress through modulation of biomolecule synthesis, the antioxidant system, and post-translational modifications. Other compounds containing the essential mineral nutrient sulfur (S) also play pivotal roles in these defense mechanisms. As biosynthesis of ethylene and H2S is connected to the S-assimilation pathway, it is logical to consider the existence of a functional interplay between ethylene, H2S, and S in relation to heat stress tolerance. The present review focuses on the crosstalk between ethylene, H2S, and S to highlight their joint involvement in heat stress tolerance.
Uncovering the Secrets of Secretory Fluids During the Reproductive Process in Ginkgo biloba

Abstract Reproduction is an essential process for all organisms. Although our understanding of the reproductive mechanism in angiosperms has rapidly advanced in recent years, it still lags behind that of gymnosperms. As an ancient gymnosperm, Ginkgo biloba has a remarkable evolutionary history and occupies an important phylogenetic position, representing one of the most ancient and primitive modes of reproduction among seed plants. G. biloba is an archegoniate, where an egg cell develops inside an archegonium; it has a particular pollen chamber and archegonial chamber along with flagellated gametes (spermatozoids). Among these processes, secretions play an important role. In this study, we review the progress on understanding the mechanisms underlying the production and function of pollination drops (PDs), and fertilization fluid in G. biloba. We also highlight recent achievements that have considerably advanced our understanding of the interactions between PDs and pollen, and how PDs are endogenously and intracellularly transported. Finally, we discuss novel insights into the small RNAs of PD transport and the mechanisms of precisely guiding pollen tube growth in G. biloba. By reviewing these results, we demonstrate the structural patterns of G. biloba pollination and fertilization, thus reproducing the uniqueness of the sexual reproduction of ancient plants.
Blockchain Adoption Readiness Assessment Framework for Health Professionals of Malaysian Public Hospitals

Healthcare professionals are the primary user of health information technology, therefore, before introducing blackchin as an underlying mechanism to Electronic Health Record (EHR), it is vital to understand their readiness to adopt it. The most influential factors of health professionals blockchain technology adoption are largely unknown from the existing literature. A limited number of studies provides a conceptual framework that can be further extended, empirically tested to develop understating in this regard particularly in developing country context like Malaysia. To fill such gaps current study, conducts a literature review to provide an compressive framework compiling the influential factors. The finding hypothesizes that the Unified Theory of Acceptance and Use of Technology (UTAUT), the Norm Activation Model (NAM), and the initial trust factors directly influences the adoption intention while, trust also plays a mediating role between those relationships. A future study will be conducted to empirically test and validate the conceptual framework that has been proposed. The framework can be extended and tasted in other developing country context.
Dynamical behaviour of a tumour-immune model focusing on the dosage of targeted chemotherapeutic drug

ABSTRACT In this paper, we have considered a tumour-immune model with the dosage effect of the targeted chemotherapeutic drug and its efficacy. The chemotherapeutic drug efficacy is characterized via way of means of its impact on the abnormal size of beginning tumours. In pharmacology, the effectiveness of a drug is a very important factor in developing a dosage for any disease. With these points of view regarding drug efficacy, we present a four compartmental mathematical model, viz, the population of tumour cells, , CD8 T-killer cells, , CD4 T-helper cells, , and the amount of targeted chemotherapeutic drug, , in the bloodstream, at any time t. A qualitative analysis of the proposed model, including the existence and boundedness of the model has been described here. The dynamics of the system are presented by examining the admissibility and stability of the system at trivial, dead, tumour-free, and co-existing equilibrium points with their respective biological significance. The conditions for the local stability of all equilibrium points are derived by using the Jacobian matrix and Routh–Hurwitz's criterion. Numerical calculations have been performed using the Multi-step Differential Transformation Method (Ms-DTM), and are presented and discussed briefly in terms of graphs. We have expressed that the model is suitable for the tumour removal with the passage of time, regardless of the initial population or tumour size. Also, the amount the dosage of the drug with an assigned numerical value for its efficacy is one of the important factors in the treatment. The efficacy term is included to see the effect of drug dosages in CD8 T-killer cells and CD4 T-helper cells compartment.
Service Quality and Customer Satisfaction in Dining Restaurants: Inputs for Tourism and Hospitality Curriculum Enhancement

In the foodservice industry, clients do not only judge the product standard, but also the service quality they receive during their restaurant experience. Therefore, when the importance of the dining experience is strongly regarded by consumers in terms of intellectual and motivational attributes, they are happier to suggest the establishment to others. This research was undertaken to evaluate the levels of service quality and clients’ satisfaction on the services offered by two leading fast-casual dining restaurants in the Province of Nueva Vizcaya, Philippines. As a correlation research, this study was conducted using a modified SERVQUAL instrument among the 395 randomly selected customers. Weighted mean was used to describe the levels of service quality and customer satisfaction. The multiple regression was used to determine the predictors of customer satisfaction. The fast-casual dining restaurants had lived up to the expectation of their customers as they were thought to provide respectable service quality. The fast-casual dining restaurants had satisfied their customers in terms of their dining experience. The physical design and appearance of the restaurants, the price of the product, and the responsiveness of the workforce are the strong determinants of the gratification of the customers.
Design of an efficient RAKE receiver architecture for multiuser detection with adaptive channel estimation

In this paper, we propose an efficient implementation scheme of wideband version of parallel interference cancellation (PIC) called regenerative PIC for multiuser detector with Rayleigh fading multipath channel and multiple access interference (MAI). Multiuser detection shall be used in the receiver. The successive PIC scheme cancels the interference of all users simultaneously. The multistage PIC suppresses the multiple access interference in multiple consecutive steps. Stage n cancels the interference by utilizing the hard symbol decision from stage n-1. The cancellation operation itself requires knowledge of the user codes, the relative code phases, complex estimates for the multipath taps, and finally hard symbol decisions for each user.
Power allocation in overlaid DVB-LTE systems

Since the launch of the first numerical mobile telecommunications networks in the nineties, the quantity of the transmitted data over the networks is increasing year by year. Advanced user equipments enable to implement more and more bandwidth consuming services such as mobile T and multimedia internet, available in the integreted mobile broadcast mode recently standardized by the 3GPP group. In the meanwhile, the digital vide broadcasting - next generation handled (DVB-NGH) has been released in order to satisfy the increasing demand for mobile TV. These technologies compete for a more and more constrained spectral resource leading to question the possibility to deploy DVB and Long Term Evolution (LTE) service in a spectral overlay mode as it has been investigated by the Ml project funded by the National Research Agency. In this context, this thesis aims at studying the spectral convergence between DVB and LTE networks by deploying a small LTE cell in a large DVB cell. Both technologies present some similarities, i.e. both use orthogonal frequency division multiplexing (OFDM) waveform (in downlink for LTE), but technical characteristics remain rather different between those. In this work, we deal with achievable performance when DVB and LTE spectrally overlap without cooperation. The considered problem being analog to the Seconda1y User (SU) - Primary User (PU) coexistence in overlay scenario, the SU ergodic capacity under average power generated on PU and peak power at SU constaints is investigated. An analytic solution is proposed in X-Channel with Rayleigh fading. In a second time, SU and PU are considered to be LTE and DVB respectively with their particular OFDM signal characteristics. With a first model of overlapping subcarriers, LTE and DVB ergodic capacities and global capacity as well are derived in closed form allowing to study the influence of several system parameters on ergodic capacities. The global capacity is then optimized using a convex-concave procedure leading to the minimum on the global capacity but to balanced capacity on individual links. On a second hand, global capacity maximization leads to favor one system over the other. Last but not least, a careful study of the interference caused by one system over the other by partial overlay is led. The effect of spectral overlap ratio between DVB and LTE systems over the global spectral efficiency is investigated. Advanced interference rejection ability is then assumed at receivers and the optimal spectral overlap, i.e. maximizing the global capacity, is then derived in that case. The different contributions in this work give a theoretical approach on the power allocation modality of two coexisting DVB and LTE systems and on the appropriate spectral overlap ratio between their respective spectrums. This study can be useful for operators interested in dense network deployment scenarios to decide the operating point of allocated resources in a very aggressive frequency reuse pattern.
Consumer Buying Behaviour Towards Khadi Fashion Wear

Studies to examine the perceived authenticity of Khadi Bhandars selling Khadi fashion wear are scarce. There has been research on Khadi textiles, but very few studies have examined consumers’ buying patterns, especially for Khadi, an authentic Indian material. This study focuses on Khadi Bhandars selling Khadi fashion wear products, and it looks at the elements that impact consumer behaviour for buying Khadi products. The participants included people who purchased Khadi textiles and fashion wear. Store atmosphere, perceived authenticity and attitude towards buying are considered as predictor variables. Exploratory factor analysis and a structural equation model were used to analyse the data. The store atmosphere is found to have a substantial influence on perceived authenticity, buying intention and attitude towards buying. An individual’s attitude and perceived authenticity have significantly influenced their buying intention, and their buying intention significantly influenced their buying behaviour.
Deformation Properties of Tailor Welded Blank Made of Dual Phase Steels

Abstract The paper is dedicated to forming and properties of passenger car’s B-pillar reinforcement drawn from simple blank and alternatively tailor-welded blank (TWB). Drawn part is characterised by a place with a large strain, while forming process simulation did not confirm the creation of crack using the TWB consisting of dual phase HCT980X instead of previous HCT600 steel. It is because HCT980X steel has higher strength and lower ductile properties. The analysis of properties of drawn parts is focused on the simulated crash test in Dynaform software. Obtained sizes of drawn forces in simulated frame of the drawn parts and their comparison proved the possibility of the replacement the 1.2 mm thick simple blank from HCT600 steel with the 1 mm thick TWB consisting of HCT600 and HCT980X steel. The changed thickness of the simple blank caused 20% weight saving while containing the same properties of the drawn part.
Panel Unit-Root Tests for Cross-Sectionally Correlated Panels: A Monte Carlo Comparison

This paper deals with the finite-sample performance of a set of unit-root tests for cross-correlated panels. Most of the available macroeconomic time series cover short time periods. The lack of information, in terms of time observations, implies that univariate tests are not powerful enough to reject the null of a unit-root while panel tests, by exploiting the large number of cross-sectional units, have been shown to be a promising way of increasing the power of unit-root tests. We investigate the finite sample properties of recently proposed panel unit-root tests for cross-sectionally correlated panels. Specifically, the size and power of Choi’s [Econometric Theory and Practice: Frontiers of Analysis and Applied Research: Essays in Honor of Peter C. B. Phillips, Cambridge University Press, Cambridge (2001)], Bai and Ng’s [Econometrica (2004), Vol. 72, p. 1127], Moon and Perron’s [Journal of Econometrics (2004), Vol. 122, p. 81], and Phillips and Sul’s [Econometrics Journal (2003), Vol. 6, p. 217] tests are analysed by a Monte Carlo simulation study. In synthesis, Moon and Perron’s tests show good size and power for different values of T and N, and model specifications. Focusing on Bai
Study on dynamics of the bubble in transformer oil under non-uniform electric field

This study explores the dynamics of gas bubbles in liquid dielectric theoretically and experimentally. A numerical model is introduced for the bubble motion in the transformer oil under non-uniform electric field. Moreover, the bubble trajectory is obtained through the force calculation of the bubble under the non-uniform electric field. The numerical calculations for different bubble sizes and applied voltages are also done. Notably, trajectories calculated indicate the bubble aggregation in concentrated area of the electric field between the needle-plane electrodes. It is concluded that the bubble can play a catalytic role in the breakdown of the oil gap. An experiment is finally conducted on the bubble motion in transformer oil gap submitted to a high divergent electric field and the suspension and aggregation of bubbles are observed before the oil gap breakdown, which confirms the results of numerical calculation.
Inside the Black Box: Political Economy Behind the TPP's Encryption Clause

Among other provisions of the Trans-Pacific Partnership (TPP) Agreement, a new clause on encryption technology (‘Encryption Clause’) is particularly noteworthy. By tracing the history of decades-long encryption control, this Article underscores how such clause implicates international order. Modern encryption technology was conceived and developed during World Wars. Painted by such a war-time legacy, encryption has been treated as a ‘dual-use’ technology and has been subject to export control since the end of World War II via the COCOM and, later, the Wassenaar Arrangement. With the collapse of the Soviet Union, the Western bloc became divided on encryption policies. The U.S. was most concerned with national security and once attempted to introduce the mandatory ‘key escrow’ scheme to provide a level playing field for its high-tech industry. Resistance to the U.S.’s hardline approach towards encryption at home and abroad led the nation to relax its export controls, thereby ending Crypto War 1.0. With the rise of emerging economies, however, Crypto War 2.0 is now resurfacing, and through the Encryption Clause, the U.S. seeks to remove trade barriers that are hostile toward products which employ foreign cryptography. Yet, underlying IPR issues and the role of intelligence units in the formation of technical standards may once again move trade negotiations into the shadows.
Long-Distance Repression by Human Silencers: Chromatin Interactions and Phase Separation in Silencers

Three-dimensional genome organization represents an additional layer in the epigenetic regulation of gene expression. Active transcription controlled by enhancers or super-enhancers has been extensively studied. Enhancers or super-enhancers can recruit activators or co-activators to activate target gene expression through long-range chromatin interactions. Chromatin interactions and phase separation play important roles in terms of enhancer or super-enhancer functioning. Silencers are another major type of cis-regulatory element that can mediate gene regulation by turning off or reducing gene expression. However, compared to active transcription, silencer studies are still in their infancy. This review covers the current knowledge of human silencers, especially the roles of chromatin interactions and phase separation in silencers. This review also proposes future directions for human silencer studies.
The Case for Octopus Consciousness: Temporality

Temporality is one of the criteria that Birch has advanced for areas of cognitive ability that may underlie animal sentience. An ability to integrate and use information across time must be more than simply learning pieces of information and retrieving them. This paper looks at such wider use of information by octopuses across time. It evaluates accumulation of information about one’s place in space, as used across immediate egocentric localization by cuttlefish and medium distance navigation in octopuses. Information about useful items in the environment can be incorporated for future use by octopuses, including for shelter in antipredator situations. Finding prey is not random but can be predicted by environmental cues, especially by cuttlefish about future contingencies. Finally, the paper examines unlimited associative learning and constraints on learning, and the ability of cephalopods to explore and seek out information, even by play, for future use.
Obstacle Detection for Autonomous Guided Vehicles through Point Cloud Clustering Using Depth Data

Autonomous driving is one of the fastest developing fields of robotics. With the ever-growing interest in autonomous driving, the ability to provide robots with both efficient and safe navigation capabilities is of paramount significance. With the continuous development of automation technology, higher levels of autonomous driving can be achieved with vision-based methodologies. Moreover, materials handling in industrial assembly lines can be performed efficiently using automated guided vehicles (AGVs). However, the visual perception of industrial environments is complex due to the existence of many obstacles in pre-defined routes. With the INDTECH 4.0 project, we aim to develop an autonomous navigation system, allowing the AGV to detect and avoid obstacles based in the processing of depth data acquired with a frontal depth camera mounted on the AGV. Applying the RANSAC (random sample consensus) and Euclidean clustering algorithms to the 3D point clouds captured by the camera, we can isolate obstacles from the ground plane and separate them into clusters. The clusters give information about the location of obstacles with respect to the AGV position. In experiments conducted outdoors and indoors, the results revealed that the method is very effective, returning high percentages of detection for most tests.