Miracle-dz/UniFAR-FTUs huggingface dataset:
A literature review of personalization transparency and control: Introducing the Transparency-Awareness-Control Framework

Through various online activities, individuals produce large amounts of data that are collected by companies for the purpose of providing users with personalized communication. In the light of this mass collection of personal data, the transparency and control paradigm for personalized communication has led to increased attention of legislators and academics. However, in the scientific literature no clear definition of personalization transparency and control exists, which could lead to reliability and validity issues, impeding knowledge accumulation in academic research. In a literature review, we analyzed 31 articles and we observed that 1) no clear definitions of personalization transparency or control exist, 2) they are used interchangeably in the literature, 3) collection, processing, and sharing of data are the three objects of transparency and control, and 4) increased transparency does not automatically increase control because first awareness needs to be raised in the individual. Also, the relationship between awareness and control depends on the ability and the desire to control. This study contributes to the field of algorithmic communication by creating a common understanding of the transparency and control paradigm and thus improves validity of the results. Further, it progresses research on the issue by synthesizing existing studies on the topic, presenting the Transparency-Awareness-Control framework, and formulating propositions to guide future research.
Prevalence of Modifiable Risk Factors among Acute Coronary Syndrome Patients in a Tertiary Care Hospital

Background and Objectives: Acute Coronary Syndrome (ACS) is one of the major causes for mortality and morbidity among the cardiovascular diseases in India. In this study the modifiable risk factors leading to ACS are considered and its prevalence in a Tertiary care hospital is studied. Materials and Methods: This is a prospective type of study conducted in a tertiary care hospital. A total of 100 patients diagnosed with ACS were taken in this study. Their data was taken, and results were formulated in excel data sheet. Results: Among the UA patients, 65% were found to be dyslipidaemic, 60% as obese, 45% as diabetics, 47.5% as hypertensive and 40% as smokers. Among the NSTEMI patients, 66.67% were found to be dyslipidaemic, 52.78% as hypertensive, 44.44% as smokers, 30.56% as diabetics and 27.78% as obese. Among the STEMI patients, 37.50% were found to be dyslipidemic, 25% as both diabetic and obese, 20.83% as hypertensive,12.5% as smokers. Hypertension, dyslipidemia, smoking and obesity showed significance. Conclusion: The prevalence of modifiable risk factors is a major concern for developing ACS and when they are modified there will be a great reduction in the incidence of ACS.
Make and break the alarmone: regulation of (p)ppGpp synthetase/hydrolase enzymes in bacteria

ABSTRACT Bacteria use dedicated mechanisms to respond adequately to fluctuating environments and to optimize their chances of survival in harsh conditions. One of the major stress responses used by virtually all bacteria relies on the sharp accumulation of an alarmone, the guanosine penta- or tetra-phosphate commonly referred to as (p)ppGpp. Under stressful conditions, essentially nutrient starvation, these second messengers completely reshape the metabolism and physiology by coordinately modulating growth, transcription, translation and cell cycle. As a central regulator of bacterial stress response, the alarmone is also involved in biofilm formation, virulence, antibiotics tolerance and resistance in many pathogenic bacteria. Intracellular concentrations of (p)ppGpp are determined by a highly conserved and widely distributed family of proteins called RelA-SpoT Homologs (RSH). Recently, several studies uncovering mechanisms that regulate RSH activities have renewed a strong interest in this field. In this review, we outline the diversity of the RSH protein family as well as the molecular devices used by bacteria to integrate and transform environmental cues into intracellular (p)ppGpp levels.
Proteomic Analysis Reveals that Di Dang Decoction Protects Against Acute Intracerebral Hemorrhage Stroke in Rats by Regulating S100a8, S100a9 Col1a1, and Col1a2

Objective The present study aimed to explore the neuroprotective mechanism of Di Dang decoction (DDD) during acute intracerebral hemorrhage (AICH) stroke in Sprague Dawley rats through proteomic analysis. Methods A total of 135 healthy Sprague Dawley rats were randomly divided into five groups: control (n = 27), model (n = 27), DDD low-dose (n = 27), DDD medium-dose (n = 27), and DDD high-dose (n = 27). AICH stroke in rats was induced by injecting autologous blood into the caudate nucleus. The modified Neurological Severity Score (mNSS) was used to evaluate the cerebral nerve function deficit. Hematoxylin and eosin (HE) staining was performed to observe the brain tissue at the lesion site. Albumin concentration was assessed on obvious blood-brain barrier damaged and brain water content was used to evaluate the brain injury. For quantitative proteomics, proteins were extracted from the cerebral cortices. Target proteins were identified using mass spectrometer-based targeted proteomic quantification. Results mNSS score, HE staining results, albumin concentration, and brain water content showed the most significant improvements in the neuroprotective in the high-dose group 7 days after DDD exposure. Furthermore, quantitative proteomics analysis showed that, relative to the control group, S100a8 and S100a9 were downregulated by 0.614 (p = 0.033702) and 0.506 times (p = 0.000024) in the high-dose group. Compared with the control group, Col1a1 and Col1a2 were upregulated by 1.319 (p = 0.000184) and 1.348 (p = 0.014097) times in the high-dose group. These results were confirmed using mass spectrometer-based targeted proteomic quantification. Conclusion Application of a high-dose DDD for 7 days in AICH stroke rats showed the most significant improvements in neuroprotective. Mechanistically, this effect was mediated by S100a8 and S100a9 protein downregulation and Col1a1 and Col1a2 upregulation.
Design of a computer based survey instrument for modelling multimodal passenger demand

This research is being undertaken with the aim of developing a comprehensive understanding of the current travel behaviour of the residents of Redland Shire, South East Queensland. A unique computer based stated preference (SP) travel survey is being conducted in the study area to determine the current modal split and to calibrate a nested logit model to forecast the future travel behaviour. This paper focuses on the new design of the computer based survey instrument that dynamically generates interactive random SP designs. The design considers all the significant travelling modes currently used in the study area including various transit access modes and also involves hypothetical travelling modes for future use. The use of the instrument in a pilot survey is discussed together with the model specification component of the study. A data collection strategy for generating the sample randomly has also been presented. The plan proposes the market segmentation to be done on the basis of stratified random sampling. It is expected that the outcomes of the research will assist policy makers in solving the strategic public transport issues and planning the network development of the transit access modes including walkways and cycleways.
A novel series resonant ZCS-PFM DC-DC power converter with loosely-coupled flyback inductors

This paper presents a novel topological prototype of voltage source series quasi-resonant zero current soft-switching pulse frequency modulated DC-DC power converter circuit using IGBTs which incorporates a high-frequency flyback transformer link. Its steady-state operating principle is described on the basis of simulation analysis, along with the open loop controlled power regulation characteristics of the multi-functional coupled inductors linked DC-DC power converter operating under a principle of zero current soft switching commutation.
Importance of Timely Treatment Initiation in Infantile-Onset Pompe Disease, a Single-Centre Experience

Classic infantile Pompe disease (IPD) is a rare lysosomal storage disorder characterized by severe hypertrophic cardiomyopathy and profound muscle weakness. Without treatment, death occurs within the first 2 years of life. Although enzyme replacement therapy (ERT) with alglucosidase alfa has improved survival, treatment outcome is not good in many cases and is largely dependent on age at initiation. The objective of the study was (a) to analyse the different stages in the diagnosis and specific treatment initiation procedure in IPD patients, and (b) to compare clinical and biochemical outcomes depending on age at ERT initiation (<1 month of age vs. <3 months of age). Here, we show satisfactory clinical and biochemical outcomes in two IPD patients after early treatment initiation before 3 months of life with immunomodulatory therapy in the ERT-naïve setting, with a high ERT dose from the beginning. Despite the overall good evolution, the patient who initiated treatment <1 month of life presented even better outcomes than the patient who started treatment <3 months of life, with an earlier normalization of hypertrophic cardiomyopathy, along with CK normalization, highlighting the importance of early treatment initiation in this progressive disease before irreversible muscle damage has occurred.
Complementary feeding hygiene practice and associated factors among mothers with children aged 6–24 months in tegedie district, Northwest Ethiopia: Community-based cross-sectional study

IntroductionHygienic practice of mothers during complementary feeding is crucial in the protection of vulnerable infants and children aged 6–24 months from childhood communicable diseases like diarrheal and malnutrition. However, sufficient evidence on hygienic practice of mothers during complementary feeding and its associated factors is limited.ObjectiveTo determine the levels of complementary feeding hygiene practice and its associated factors among mothers of children aged 6–24 months in Tegedie district, northwest Ethiopia.MethodsA community-based cross-sectional study was conducted from March 17 to April 17, 2021, among 576 mothers with children aged 6-24 months in Tegedie district northwest Ethiopia. A multistage sampling technique was used to select the study participants. Data were collected using an interviewer-administered structured questionnaire and it entered into Epi-data version 4.6, and exported to SPSS version 20.0 for data cleaning and further analysis. Bivariate and multivariable binary logistic regressions analysis were employed to identify predictors of complementary feeding hygiene practice with p-value < 0.25 enter into the multivariable logistic regression model. Then variables with p-value ≤ 0.05 in multivariable logistic regressions were considered as statistically significance.ResultsThe prevalence of hygienic practice during complementary feeding of their children aged 6-24 months was, 33.6% with 95% CI: (29.7%, 37.6%) of them had good practice. Living in urban areas [AOR= 7.02, 95% CI: (4.14, 11.88)], presence of hand washing facility near the latrine [AOR= 3.02, 95% CI: (1.18, 7.70)], presence of separate area to store raw and cooked foods [AOR= 5.87, 95% CI: (2.84, 12.13)] and presence of three-compartment dishwashing system [AOR= 5.70, 95% CI: (3.41, 9.54)] were significant predictors of hygienic complementary feeding practice.Conclusion and recommendationThe prevalence of good hygienic practice during complementary feeding among mothers was still low; the district health office and health extension workers should work to improve the maternal hygienic practices during complementary feeding practice.
123 P-MUC1C-ALLO1: A fully allogeneic stem cell memory T cell (TSCM) CAR-T therapy with broad potential in solid tumor

While CAR-T have demonstrated potent activity against hematologic tumors, less success has been seen with solid tumors. Here we report generation of TSCM-enriched allogeneic MUC1-C-specific CAR T cells, P-MUC1C-ALLO1, with potential for a broad range of solid tumors. The proliferative capacity and metabolic profile of TSCM CAR-T are well-suited to activity in the solid tumor setting. MUC1 is comprised of an N-terminal subunit (MUC1-N) tethered to a C-terminal subunit (MUC1-C), forming a stable complex on the cell surface. During tumorigenesis, MUC1 becomes both overexpressed and hypo-glycosylated on many carcinomas. Furthermore, MUC1 undergoes proteolytic cleavage in the tumor microenvironment, leaving behind a proteolytic ‘stump’ of MUC1-C that is over-represented in cancer, making it an attractive therapeutic target.P-MUC1C-ALLO1 is manufactured using the piggyBac® DNA Delivery System for CAR insertion and the Cas-CLOVER™ Gene Editing System to knockout both the TCR and MHC class I proteins. The addition of a selectable marker within the transposon allows for selection of a fully CAR-positive population while any residual TCR-positive cells are removed at the end of production to prevent TCR-mediated GvHD. Lastly, inclusion of a proprietary ‘booster molecule’ in our allogeneic process further improves cell expansion, along with phenotype and function, and enables the production of up to hundreds of patient doses from a single manufacturing run.Significant doses of P-MUC1C-ALLO1 products made from multiple healthy donors were achieved and comprised of an exceptionally high-percentage of desirable TSCM cells. Preclinical evaluation of these products showed potent tumor killing and cytokine secretion against MUC1-C-positive breast and ovarian tumor cell lines. P-MUC1C-ALLO1 demonstrates potent cytotoxicity against tumor cells, and minimal killing of normal MUC1-C-positive human primary cells. In a triple negative breast cancer xenograft model, MUC1C CAR-T eliminated established MDA-MB-468 tumor cells, mounted robust T cell expansion in peripheral blood and maintained a favorable TSCM percentage over time. Likewise, in an orthotopic ovarian cancer xenograft model, intraperitoneally administered MUC1C CAR-T eliminated established OVCAR3 cells to levels below the limit of detection. All together, these data demonstrated the efficacy of the MUC1C CAR-T cells and the robustness of the allogeneic platform.P-MUC1C-ALLO1 is an allogeneic TSCM CAR-T therapy that has a potential to treat multiple MUC1-expressing indications. P-MUC1C-ALLO1 displayed specificity for tumor vs. normal cells as well as in vivo efficacy against xenograft models of breast and ovarian cancer. This allogeneic cell therapy is advancing rapidly towards the clinic.
A Leader-Follower Formation Control of Multi-UAVs via an Adaptive Hybrid Controller

The purpose of this study is to offer an adaptive hybrid controller for the formation control of multiple unmanned aerial vehicles (UAVs) leader-follower configurations with communication delay. Although numerous studies about the control of the formation exist, very few incorporate the delay in their model and are adaptive as well. The motivation behind this article is to bridge that gap. The strategy consists of an adaptive fuzzy logic controller and a Proportional, Integral, and Derivative (PID) controller where the logic controller fines/tunes the PID controller gains. The controller also consists of an integrator that raises the order of the system which helps reduce the noise and steady-state errors. The simulations confirm that the proposed technique is robust and satisfies mission requirements. Moreover, the flying formations of the swarm were created by a B-spline curve based on a simple waypoint. The main contribution of this study is to present a model where the formation remains stable during the whole flight, errors are within the optimal range, and the time delays are manageable.
Outdoor Path Propagation Modelling in a Building of Rajasthan at Frequencies of 900MHz and 2.1GHz

Today many models are available for estimating RF signals through path propagation modelling for indoor as well as outdoor scenarios. Since all models are site specific, there is a vital need for simple models especially for environment pertaining to outdoor conditions of dry and hot conditions alike present in Rajasthan. This paper investigates the behaviour of RF frequencies of 900MHz and 2.1GHz, for envisaging the path propagation model. Here we have used a simplistic single slope model and have calculated path loss index for various scenarios in outdoor conditions [1, 11]. This path loss index can be directly used to estimate the received power at any position of cell site in similar outdoor condition modelled in this paper.
Electrospun Nanofiber and Cryogel of Polyvinyl Alcohol Transdermal Patch Containing Diclofenac Sodium: Preparation, Characterization and In Vitro Release Studies

Transdermal drug delivery systems (TDDS) have drawn more interest from pharmaceutical scientists because they could provide steady blood levels and prevent the first-pass metabolism over a longer period. Polyvinyl alcohol (PVA) has been widely used in this application due to its biocompatibility, non-toxicity, nanofiber and hydrogel-forming ability. Despite those benefits, their morphology would easily be destroyed by continuous water absorption and contribute to burst drug release due to its hydrophilicity. The aim of this study was to prepare the diclofenac sodium (DS)-medicated dual layer PVA patch using a combination of electrospinning and cryogelation (freeze–thaw) methods to improve the physicochemical properties and drug compatibility and investigate the release of the DS-medicated dual layer PVA patch. Morphological observations using scanning electron microscopy (SEM) verified the polymer−polymer interaction between both layers, whereas Fourier transform infrared (FTIR) spectroscopy has demonstrated the compatibility of DS in PVA matrix up to 2% w/v of PVA volume. The DS loads were found amorphously distributed efficaciously in PVA matrix as no visible spectra of DS–PVA interaction were detected. The DS-medicated dual layer PVA patch with a thicker nanofiber layer (3-milliliter running volume), three freeze–thaw cycles and 2% DS loading labeled as 2%DLB3C show the lowest swelling capacity (18.47%). The in vitro assessment using Franz diffusion cells showed that the 2%DLB3C indicates a better sustained release of DS, with 53.26% of the DS being released after 12 h. The 2%DLB3C owned a flux (Jss) of 0.256 mg/cm2/h and a permeability coefficient (Kp) value of 0.020 cm/h. Thus, the results demonstrate that DS-medicated dual layer PVA patches prepared via a combination of electrospinning and cryogelation are capable of releasing drugs for up to 24 h and can serve as a drug reservoir in the skin, thereby extending the pharmacologic effects of DS.
Characterizing the Genomic Profile in High-Grade Gliomas: From Tumor Core to Peritumoral Brain Zone, Passing through Glioma-Derived Tumorspheres

Simple Summary The genomic landscape of the stem cell compartment and peritumoral brain zone of glioblastoma is still incomplete. The key role of the stem component in tumor maintenance and progression, as well as in drug-resistance spreading, has already been demonstrated. In recent years, the importance of the marginal area of the neoplasm has been considered since this is where the tumor recurrences appear in up to 90% of cases. In this study, we carried out a 360° genomic profile analysis of the different glioblastoma components in order to understand how they are characterized and how they work. Studying their genomic constitution is the starting point necessary to finally develop target treatments associable with the standard ones, as a new hope for glioblastoma patients. Abstract Glioblastoma is an extremely heterogeneous disease. Treatment failure and tumor recurrence primarily reflect the presence in the tumor core (TC) of the glioma stem cells (GSCs), and secondly the contribution, still to be defined, of the peritumoral brain zone (PBZ). Using the array-CGH platform, we deepened the genomic knowledge about the different components of GBM and we identified new specific biomarkers useful for new therapies. We firstly investigated the genomic profile of 20 TCs of GBM; then, for 14 cases and 7 cases, respectively, we compared these genomic profiles with those of the related GSC cultures and PBZ biopsies. The analysis on 20 TCs confirmed the intertumoral heterogeneity and a high percentage of copy number alterations (CNAs) in GBM canonical pathways. Comparing the genomic profiles of 14 TC-GSC pairs, we evidenced a robust similarity among the two samples of each patient. The shared imbalanced genes are related to the development and progression of cancer and in metabolic pathways, as shown by bioinformatic analysis using DAVID. Finally, the comparison between 7 TC-PBZ pairs leads to the identification of PBZ-unique alterations that require further investigation.
Financial Management Primer for New Project Managers

The basics of financial management for new project managers are introduced. As a primer, managers can familiarize themselves with common accounting methods and systems, various accounting reports and financial documents, and financial ratios used to measure project and firm-wide financial performances. Proper financial management requires a reporting system that supplies both cash and accrual methods of accounting. The general ledger and the charts of accounts are the heart of the general accounting system, where the latter is the starting point in establishing the firm's accounting system. Project accounting system and cost accounting technique are also explained. Using financial data generated from the accounting information system, the balance sheet and income statement are prepared as primary documents to ascertain financial health of the firm. Financial ratios utilize the information provided by these documents. Four key ratios are discussed. These basic ratios are important indicators of performance.