Miracle-dz/UniFAR-FTUs huggingface dataset:
Antiviral Effect of Isoquercitrin against Influenza A Viral Infection via Modulating Hemagglutinin and Neuraminidase

Isoquercitrin (IQC) is a component abundantly present in many plants and is known to have an anti-viral effect against various viruses. In this study, we demonstrate that IQC exhibits strong anti-influenza A virus infection, and its effect is closely related to the suppression of hemagglutinin (HA) and neuraminidase (NA) activities. We used green fluorescent protein-tagged Influenza A/PR/8/34 (H1N1), A/PR/8/34 (H1N1), and HBPV-VR-32 (H3N2) to evaluate the anti-IAV effect of IQC. The fluorescence microscopy and fluorescence-activated cell sorting analysis showed that IQC significantly decreases the levels of GFP expressed by IAV infection, dose-dependently. Consistent with that, IQC inhibited cytopathic effects by H1N1 or H3N2 IAV infection. Immunofluorescence analysis confirmed that IQC represses the IAV protein expression. Time-of-addition assay showed that IQC inhibits viral attachment and entry and exerts a strong virucidal effect during IAV infection. Hemagglutination assay confirmed that IQC affects IAV HA. Further, IQC potently reduced the NA activities of H1N1 and H3N2 IAV. Collectively, IQC prevents IAV infection at multi-stages via virucidal effects, inhibiting attachment, entry and viral release. Our results indicate that IQC could be developed as a potent antiviral drug to protect against influenza viral infection.
Comparative Study of Carbon Nanotube Composites as Capacitive and Piezoresistive Pressure Sensors under Varying Conditions

Conducting polymer composites consisting of carbon nanotubes (CNTs) as a conductive filler and polydimethylsiloxane (PDMS) as a polymer matrix were fabricated to investigate their capacitive and piezoresistive effects as pressure sensors. The pressure-sensing behavior and mechanism of the composites were compared in terms of basic configuration with a parallel plate structure. Various sensing experiments, such as sensitivity, repeatability, hysteresis, and temperature dependence according to the working principle, were conducted with varying filler contents. The hysteresis and repeatability of the pressure-sensing properties were investigated using cyclic tensile tests. In addition, a temperature test was performed at selected temperatures to monitor the change in the resistance/capacitance.
BEOL compatible high tunnel magneto resistance perpendicular magnetic tunnel junctions using a sacrificial Mg layer as CoFeB free layer cap

Perpendicularly magnetized MgO-based tunnel junctions are envisaged for future generation spin-torque transfer magnetoresistive random access memory devices. Achieving a high tunnel magneto resistance and preserving it together with the perpendicular magnetic anisotropy during BEOL CMOS processing are key challenges to overcome. The industry standard technique to deposit the CoFeB/MgO/CoFeB tunnel junctions is physical vapor deposition. In this letter, we report on the use of an ultrathin Mg layer as free layer cap to protect the CoFeB free layer from sputtering induced damage during the Ta electrode deposition. When Ta is deposited directly on CoFeB, a fraction of the surface of the CoFeB is sputtered even when Ta is deposited with very low deposition rates. When depositing a thin Mg layer prior to Ta deposition, the sputtering of CoFeB is prevented. The ultra-thin Mg layer is sputtered completely after Ta deposition. Therefore, the Mg acts as a sacrificial layer that protects the CoFeB from sputter-indu.
Increased proximal tubular cell catalytic iron content: a result, not a mediator of, hypoxia-reoxygenation injury.

F c-catalyzed free radical reactions (e.g. , the Haber Weiss reaction, resulting in hydroxyl radical production) have been implicated in several forms of tissue injury ( 1 ), Including postischemic acute renal failure (ARF) (2). The two pieces of evidence supporting a robe for Fe In the batter disease are that: (1 ) the Fe chelator deferoxamine (DFO) may confer renal functional/morphologic protection (2): and (2) increased urinary (2) and renal parenchymal (3) catalytic Fe concentrations have been documented after In viva ischemic renal damage, as assessed by the bleomycmn assay technique (2-4). It should be noted, however, that although suggestive, these findings cannot be taken as proof of the pathogenic robe of Fe In postischemic ARF for at beast two reasons:first, DFO could conceivably confer in viva renal protection via a non-Fe-dependent mechanism. Of note In this regard are unpublished findings from this laboratory indicating that DFO can exert a modest diuretic effect. Second, Increased postischemlc urinary and tissue catalytic Fe content could be a resutt of tissue injury and not necessarily a mediator of It. For cxample, cell injury might nonspecificabby liberate Fe from Intracellular heme proteins (e.g. , cytochnomes). Because free, but not protein-bound, Fe catalyzes free radical reactions, an intracellular Fe translocation could increase its catalytic activity. Alternativeby, Intrarenal blood trapping, characteristic of postischemlc ARF (e.g. , reference 5), could artifactually raise renal catalytic Fe content as a result of tissue homogenization, a necessary first step in tissue Fe analysis. In support of this possibility are unpublished observations from this laboratory that ex viva hemobysis causes striking catalytic Fe generation.
Pauli blockade of the electron spin flip in bulk GaAs

By means of time-resolved optical orientation under strong optical pumping, the k-dependence of the electron spin-flip time (t_sf) in undoped GaAs is experimentally determined. t_sf monotonically decreases by more than one order of magnitude when the electron kinetic energy varies from 2 to 30 meV. At the high excitation densities and low temperatures of the reported experiments the main spin-flip mechanism of the conduction band electrons is the Bir-Aronov-Pikus. By means of Monte-Carlo simulations we evidence that phase-space filling effects result in the blocking of the spin flip, yielding an increase of t_sf with excitation density. These effects obtain values of t_sf up to 30 ns at k=0, the longest reported spin-relaxation time in undoped GaAs in the absence of a magnetic field.
Theory of reflectance and emittance spectroscopy

Acknowledgements 1. Introduction 2. Electromagnetic wave propagation 3. The absorption of light 4. Specular reflection 5. Single particle scattering: perfect spheres 6. Single particle scattering: irregular particles 7. Propagation in a nonuniform medium: the equation of radiative transfer 8. The bidirectional reflectance of a semi-infinite medium 9. The opposition effect 10. A miscellany of bidirectional reflectances and related quantities 11. Integrated reflectances and planetary photometry 12. Photometric effects of large scale roughness 13. Polarization 14. Reflectance spectroscopy 15. Thermal emission and emittance spectroscopy 16. Simultaneous transport of energy by radiation and conduction Appendix A. A brief review of vector calculus Appendix B. Functions of a complex variable Appendix C. The wave equation in spherical coordinates Appendix D. Fraunhoffer diffraction by a circular hole Appendix E. Table of symbols Bibliography Index.
Virtual sources and receivers in the real Earth, a method for induced seismicity monitoring.

To enhance the monitoring of the subsurface, virtual receivers can be deployed, which can be created by the Marchenko method. These virtual receivers are used to study real source signals in the subsurface. To use the virtual receivers with a real source, homogeneous Green's function retrieval is required. Classical homogeneous Green's function retrieval requires an enclosing recording surface, however by using a single-sided retrieval scheme, this requirement can be avoided. We first show that the construction of a homogeneous Green's function on a field dataset from the V{\o}ring basin can be achieved. To this end, we show the retrieval of virtual receivers on a synthetic dataset that is based on the field dataset. Because the Marchenko method is sensitive to recording limitations with the reflection data, we consider several limitations on the synthetic data. We take these limitations into account for the field dataset, by processing the reflection data. A comparison is made between the single-sided and classical retrieval of the homogeneous Green's function. We consider two different mechanisms for the virtual source, a monopole point source and a double-couple source. The homogeneous Green's function retrieved from the field data shows potential for monitoring of the wavefield and the source mechanism.
Discovery of a Type 2 Quasar at z = 0.9

We report the discovery of a narrow-line, X-ray-luminous galaxy at z = 0.9, which is the counterpart of an X-ray source detected in a deep pointing observation with the Advanced Satellite for Cosmology and Astrophysics. The object has a hard X-ray spectrum; it is significantly detected only in the 2-10 keV band, with a flux of ~1 × 10-13 ergs s-1 cm-2. Its rest X-ray luminosity in the 2-10 keV band is estimated to be ~1 × 1044 ergs s-1 (q0 = 0.5, H0 = 50 km s-1 Mpc-1). The optical spectrum shows high-excitation and high-ionization lines but no significant broad emission line component. All these properties imply that this object is a “type 2 QSO. ”
Synchrotron self-absorption in GRB afterglows: the effects of a thermal electron population

In the standard synchrotron afterglow model, a power law of electrons is responsible for all aspects of photon production and absorption. Recent numerical work has shown that the vast majority of particles in the downstream medium are actually "thermal" particles, which were shock-heated but did not enter the Fermi acceleration process (the name stands in contrast to the nonthermal high-energy tail, rather than connoting a Maxwellian distribution). There are substantial differences at optical and higher energies when these thermal electrons participate in the afterglow, but early work along these lines ignored the radio end of the electromagnetic spectrum. We report here on an extension of previous Monte Carlo simulations of gamma-ray burst afterglows. The model now includes the synchrotron self-absorption (SSA) process and so can simulate afterglows across the entire EM spectrum, and several orders of magnitude in time. In keeping with earlier work, inclusion of the thermal electrons increases the SSA frequency by a factor of 30, and the radio intensity by a factor of 100. Furthermore, these changes happen with no modification to the late optical or X-ray afterglow. Our results provide very strong evidence that thermal electrons must be considered in any multiwavelength model for afterglows.
The Peculiar Multiwavelength Evolution Of V1535 Sco

We present multiwavelength observations of the unusual nova V1535 Sco throughout its outburst in 2015. Early radio observations were consistent with synchrotron emission, and early X-ray observations revealed the presence of high-energy (>1 keV) photons. These indicated that strong shocks were present during the first ∼2 weeks of the nova's evolution. The radio spectral energy distribution was consistent with thermal emission from week 2 to week 6. Starting in week 7, the radio emission again showed evidence of synchrotron emission, and there was an increase in X-ray emission, indicating a second shock event. The optical spectra show evidence of at least two separate outflows, with the faster outflow possibly having a bipolar morphology. The optical and near-infrared light curves and the X-ray measurements indicated that the companion star is likely a K giant.
Forest–Fruticulture Conversion Alters Soil Traits and Soil Organic Matter Compartments

Fruticulture in the Amazonian Rainforest is one of the main causes of deforestation, biodiversity loss, and soil erosion. Fruticulture plays a key role in the soil traits and soil organic matter (SOM) compartments by altering the soil ecosystem. Our aim was to assess the influence of Forest–Fruticulture conversion on soil traits, and SOM fractions in Brazil’s Legal Amazon. The experiment was carried out in field conditions using four land uses as main treatments: Bixa orellana, Theobroma grandiflorum, Paullinia cupana, and the Amazon Rainforest. The soil physicochemical traits were analyzed using samples that were collected from 0–5, 5–10, and 10–20 cm soil depth by using grids (10 × 10 m) with 36 sampling points. Our results showed that the Fruticulture promoted an increase in bulk density, GMD, aggregate diameter, soil porosity, gravimetric moisture, sand, clay, carbon associated with humic acid, and, the sum of bases (K+, Ca2+, and Mg2+), while the Amazon Rainforest showed the highest values of silt, soil P content, SOC, p-SOC, m-SOC, carbon associated with fulvic acid, humine, and soil C stock. Overall, the fruticulture farming systems have negative effects on SOM compartments. The results of our study highlight the importance of considering fruticulture with endemic plant species by promoting soil fertility and soil aggregation.
Rabi frequency of the HΔ13 to CΠ1 transition in ThO: Influence of interaction with electric and magnetic fields

Calculations of the correlations between the Rabi frequency on the $H^3\Delta_1$ to $C^1\Pi$ transition in ThO molecule and experimental setup parameters in the electron electric dipole moment (eEDM) search experiment is performed. Calculations are required for estimations of systematic errors in the experiment due to imperfections in laser beams used to prepare the molecule and read out the eEDM signal.
A Linguistic Analysis of News Coverage of E-Healthcare in China with a Heterogeneous Graphical Model

E-healthcare has been envisaged as a major component of the infrastructure of modern healthcare, and has been developing rapidly in China. For healthcare, news media can play an important role in raising public interest and utilization of a particular service and complicating (and, perhaps clouding) debate on public health policy issues. We conducted a linguistic analysis of news reports from January 2015 to June 2021 related to E-healthcare in mainland China, using a heterogeneous graphical modeling approach. This approach can simultaneously cluster the datasets and estimate the conditional dependence relationships of keywords. It was found that there were eight phases of media coverage. The focuses and main topics of media coverage were extracted based on the network hub and module detection. The temporal patterns of media reports were found to be mostly consistent with the policy trend. Specifically, in the policy embryonic period (2015–2016), two phases were obtained, industry management was the main topic, and policy and regulation were the focuses of media coverage. In the policy development period (2017–2019), four phases were discovered. All the four main topics, namely industry development, health care, financial market, and industry management, were present. In 2017 Q3–2017 Q4, the major focuses of media coverage included social security, healthcare and reform, and others. In 2018 Q1, industry regulation and finance became the focuses. In the policy outbreak period (2020–), two phases were discovered. Financial market and industry management were the main topics. Medical insurance and healthcare for the elderly became the focuses. This analysis can offer insights into how the media responds to public policy for E-healthcare, which can be valuable for the government, public health practitioners, health care industry investors, and others.
Structural Optimization of Platinum Drugs to Improve the Drug-Loading and Antitumor Efficacy of PLGA Nanoparticles

Currently, molecular dynamics simulation is being widely applied to predict drug–polymer interaction, and to optimize drug delivery systems. Our study describes a combination of in silico and in vitro approaches aimed at improvement in polymer-based nanoparticle design for cancer treatment. We applied the PASS service to predict the biological activity of novel carboplatin derivatives. Subsequent molecular dynamics simulations revealed the dependence between the drug–polymer binding energy along with encapsulation efficacy, drug release profile, and the derivatives’ chemical structure. We applied ICP-MS analysis, the MTT test, and hemolytic activity assay to evaluate drug loading, antitumor activity, and hemocompatibility of the formulated nanoparticles. The drug encapsulation efficacy varied from 0.2% to 1% and correlated with in silico modelling results. The PLGA nanoparticles revealed higher antitumor activity against A549 human non-small-cell lung carcinoma cells compared to non-encapsulated carboplatin derivatives with IC50 values of 1.40–23.20 µM and 7.32–79.30 µM, respectively; the similar cytotoxicity profiles were observed against H69 and MCF-7 cells. The nanoparticles efficiently induced apoptosis in A549 cells. Thus, nanoparticles loaded with novel carboplatin derivatives demonstrated high application potential for anticancer therapy due to their efficacy and high hemocompatibility. Our results demonstrated the combination of in silico and in vitro methods applicability for the optimization of encapsulation and antitumor efficacy in novel drug delivery systems design.
Biocontrol Ability and Action Mechanism of Meyerozyma guilliermondii 37 on Soft Rot Control of Postharvest Kiwifruit

Postharvest soft rot of kiwifruit has resulted in substantial market losses, yet there were few antagonistic yeasts reported to control the disease. This study screened 1113 yeast strains for potential antagonistic yeast to control soft rot of kiwifruit caused by Botryosphaeria dothidea and Diaporthe actinidiae, and strain 37 was selected to evaluate the control efficacy and mechanisms, which was identified as Meyerozyma guilliermondii via molecular biological identification. Our results showed that M. guilliermondii 37 effectively reduced pathogen spore germination rate to 28.52% and decay incidence of inoculated kiwifruit to 42.11% maximumly, whereas cell-free supernatant lacked antifungal activity, implying that M. guilliermondii 37 didn’t produce direct antifungal compounds against the two pathogens. In addition, M. guilliermondii 37 adhered tenaciously to the pathogens’ mycelium and colonized rapidly in kiwifruit flesh. Moreover, yeast strain 37 induced kiwifruit resistance by elevating the defense-related enzyme activity, increasing the antioxidant substances content, and suppressing the cell wall-degrading enzyme activity. Gene expression was consistent with the corresponding enzyme activity. Further postharvest yeast immersion treatment significantly reduced natural decay to 35.69% while maintaining soft-ripe quality. These results indicated that M. guilliermondii 37 might serve as a biocontrol agent against postharvest soft rot in kiwifruit.
XMM-Newton Survey of Local O vii Absorption Lines in the Spectra of Galactic X-Ray Sources

The detection of highly ionized metal absorption lines in the X-ray spectra of the Galactic X-ray binaries (XRBs) implies the distribution of hot gas along the sightline toward the background sources. However, the origin of this hot gas is still unclear: it can arise in the hot interstellar medium (ISM), or is intrinsic to the XRBs. In this paper, we present an XMM-Newton survey of the O vii absorption lines in the spectra of Galactic XRBs. A total of 33 XRBs were selected, with 29 low-mass XRBs and 4 high-mass XRBs. At a more than 3σ threshold, O vii absorption line was detected in 16 targets, among which 4 were newly discovered in this work. The average line equivalent width is centered around ∼20 mÅ. Additionally, we do not find strong correlations between the O vii EWs and the Galactic neutral absorption NH, the Galactic coordinates, or the distance of background targets. Such non-correlation may suggest contamination of the circumstellar material, or a lack of constraints on the line Doppler-b parameter. We also find that regardless of the direction of the XRBs, the O vii absorption lines are always detected when the flux of the background XRBs reaches a certain level, suggesting a uniform distribution of this hot gas. We estimate a ratio of 0.004–0.4 between the hot and neutral phases of the ISM. This is the second paper in the series following Fang et al. (2015), in which we focused on the local O vii absorption lines detected in the background AGN spectra. Detailed modeling of the hot ISM distribution will be investigated in a future paper.
Genomic Signatures Reveal Breeding Effects of Lulai Pigs

In Chinese pig populations in which crossbreeding is used, these animals show a level of weakness compared with their original purebred ancestors. For instance, in the Lulai pig, a newly developed Chinese breed that is raised on the basis of the Laiwu pig (a Chinese indigenous breed with exceptionally high intramuscular fat content) and the Yorkshire pig using a method of systematic crossbreeding, both their market acceptance and performance are inferior. To reveal the practical role of these admixed breeds and traditional systematic crossbreeding methods at the genomic level, we explored population structure, genetic signatures, and introgression. We conducted this study based on the SNP chip data of 381 Lulai pigs, 182 Laiwu pigs, and 127 Yorkshires, which showed deficient genome coverage during our study. Therefore, we further selected the Genotyping by Genome Reducing and Sequencing (GGRS) method, which has a high density and suitable genome coverage as a supplement. We applied the GGRS data of 38 Lulai pigs, 75 Laiwu pigs, and 75 Yorkshires. In terms of the SNP chip data, by Fst analysis, we detected 782 significantly different genes between Lulai pigs and Yorkshires, including 3 major genes associated with growth (LEPR) and meat quality (SCD and TBC1D1), and we detected 426 significantly different genes between Lulai pigs and Laiwu pigs. With rIBD, we detected 12 genomic regions that included 182 genes that Yorkshires introgressed to Lulai pigs, and we detected 27 genomic regions that included 229 genes with a major gene (SCD) that Laiwu pigs introgressed to Lulai pigs. Regarding the GGRS data, we detected 601 significantly different genes between Lulai pigs and Yorkshires by Fst analysis, including 3 major genes associated with growth and fat deposits (IGF2 and FTO) and with hair color (KIT), and we detected 634 significantly different genes between Lulai pigs and Laiwu pigs, including 3 major genes related to their body composition (MYPN), hair color (KIT), and ear size (PPARD). By rIBD, we detected 94 deep sections that included 363 genes that Yorkshires introgressed to Lulai pigs, and we detected 149 deep sections that included 727 genes with a major gene (ESR1) that Laiwu pigs introgressed to Lulai pigs. Altogether, this study provides both insight into the molecular background of synthesized breeds of Lulai pigs and a reference for the evaluation of systematic crossbreeding in China.
Ontology Design Patterns for Winston ’ s Taxonomy Of Part-Whole Relations

While the formal modeling of part-whole relationships has been of interest, and studied, in many fields including ontology modeling, as of yet there has been no dedicated ontology design pattern which goes beyond the modeling of an absolute minimum. We correct this by providing two patterns based on Winston’s landmark paper, “A Taxonomy of Part-Whole Relations. ”