Miracle-dz/UniFAR-FTUs huggingface dataset:
Genetic variation of olfactory receptor gene family in a Japanese population

The olfactory receptor (OR) gene family is comprised of hundreds of intact and disrupted genes in humans. The compositions and copy number variation (CNV) of disrupted and intact OR genes among individuals is expected to cause variation in olfactory perception. However, little is known about OR genetic variation in many human populations. In this study, we used targeted capture enrichment and massive parallel short-read sequencing methods to examine genetic variation of OR genes, as well as of neutral genome regions as references, for 69 anonymized unrelated Japanese individuals. The capture probes were designed for 398 intact OR genes in the human reference genome hg38, and 85 neutral references. Probes were also designed for four unannotated and 99 ‘nearly-intact’ (hg38-pseudo) OR genes in hg38 and 53 chimpanzee OR genes in the Pantro3.0 genome database with no orthologs in hg38. All the hg38 OR genes and one Pantro 3.0 OR gene were retrieved. The mean sequencing depth was significantly higher than that of the 1000 Genomes Project. A total of 30 OR genes from hg38-intact and hg38-pseudo categories were newly found to be segregating pseudogenes. One hg38-pseudo OR gene was intact in all individuals. CNV was detected in 63 OR genes. Tajima’s D analysis for OR genes and neutral references was consistent with balancing selection to maintain allelic differences in intact OR genes. These results demonstrate that the targeted capture by probes with diversity-oriented design is far more effective than a whole-genome approach to retrieve OR genes and achieve high-depth sequencing and thus to reveal polymorphisms for the OR multigene family. The composition of OR genes in the human reference genome hg38 does not necessarily represent those in many humans, implying higher perceptual variation than previously thought. The current study inspires further investigation with a similar approach at a global scale.
Short-chain fructooligosaccharides from sucrose and maintenance of normal defecation: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

Following an application from Beghin-Meiji and Tereos Syral, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA Panel) was asked to deliver an opinion on the scientific substantiation of a health claim related to short-chain fructooligosaccharides (scFOS) from sucrose and maintenance of normal defecation. The food constituent that is the subject of the health claim is scFOS from sucrose. The Panel considers that scFOS from sucrose is sufficiently characterised. The claimed effect proposed by the applicant is ‘maintaining normal intestinal transit regularity by increasing stool frequency’. The target population proposed by the applicant is the general population. Upon a request from EFSA, the applicant confirmed that the proposed claimed effect refers to maintenance of normal defecation. The Panel considers that maintenance of normal defecation is a beneficial physiological effect. The Panel considers that one human intervention study did not show an effect of scFOS from sucrose at a dose of 5.7 g/day for 4 weeks on defecation frequency, consistency of stools or dry faecal mass and that in two other human intervention studies 10 g/day of scFOS increased faecal bulk, whereas higher amounts (12.5 g/day) consumed for shorter period did not. Although a number of studies provided some evidence that scFOS are fermented in the colon and increase bacterial mass and faecal bulk, the information provided does not demonstrate that the changes in short-chain fatty acids (SCFA) or bile acids induced by scFOS lead to significant changes in the frequency of stools. The Panel concludes that a cause and effect relationship has not been established between the consumption of scFOS from sucrose and maintenance of normal defecation under proposed conditions of use. © European Food Safety Authority, 2016
Anion-Exchange Extraction of Cephapirin , Cefotaxime , and Cefoxitin from Serum for Liquid Chromatography

An anion-exchange column technique for extraction of antibiotics from serum proteins has been developed for use in the assay of cephapirin, cefotaxime, and cefoxitin by high-pressure liquid chromatography. Anion-exchange extraction of cephapirin from serum samples by this technique was compared with protein precipitation methods, using 6% trichloroacetic acid or absolute ethanol. Column extraction gave improved quantitative drug recovery and reduced background serum interferences in the resultant chromatograms when evaluated against protein precipitation. Comparisons of this method with microbiological assay gave statistically equivalent results. Twelve patient samples were assayed for cephapirin, and no interferences were encountered from the 22 systemic agents these subjects were receiving. The anion-exchange technique for antibiotic extraction provides a rapid, precise, and quantitative antibiotic assay when used with liquid chromatography.
Umm Al Qura University Students Ideas about Adult Cardiopulmonary Resuscitations

Background: Cardiopulmonary Resuscitation (CPR) is known as a life saving technique significantly use din management of dyspnea, tachycardia, arrhythmias, and other cardiac complications. Purpose: To investigate the knowledge and awareness about cardiopulmonary resuscitation among the preparatory year students of Umm Al-Qura University. Methods: 98 students were randomly selected from preparatory year of Umm Al-Qura University, who filled questionnaires related about their knowledge of CPR that was compared using test analysis. Results: The average knowledge of CPR was 7.97, a practice skill was 9.4, and importance level was 10.6 among the students. There was no difference in average level of knowledge, practice skills, and importance level regarding learning of CPR between the students of administrative and scientific programs. There was lack of awareness among the students regarding the importance of learning CPR. Conclusion: The overall knowledge, practice skills, and importance level of CPR among the students was moderate; however, increased knowledge about cardiopulmonary resuscitation will improve the practical skills among students.
BENEFITS OF EMOTIONAL PROCESSING AND SELF-CONTROL IN ADOLESCENTS WITH TYPE 1 DIABETES

The objective of this study was to examine how emotional processing (i.e., understanding, acknowledging, and accepting emotions) moderated self-control (i.e., regulation of thoughts, emotion, and behavior) in explaining diabetes-specific selfregulation and metabolic control in adolescents with type 1 diabetes. Strong emotional processing was expected to confer regulatory benefit and promote adaptive outcomes, especially so for adolescents with poor self-control. General self-control capacity, and particularly self-control combined with emotional processing, may also underlie the relation of diabetes-specific management self-competence, negative affect, and adherence, and metabolic control. Self-report measures of self-control, emotional processing, diabetes management self-competence, diabetes-specific negative affect, adherence, and measured HbA1c were obtained from 137 adolescents with type 1 diabetes (M age = 13.48 years). Emotional processing significantly moderated the relation of self-control and metabolic control. Adolescents with high emotional processing were buffered from the effects of poor self-control. Adolescents with low self-control and low emotional processing had the poorest metabolic control. This interaction predicted metabolic control better than diabetes-specific self-regulatory constructs, and mediated the relations between those constructs and metabolic control. These findings suggest the importance of considering strength of emotional processing and self-control in the study of diabetesspecific self-regulation and health outcomes in adolescents with type 1 diabetes.
IMAGE PROCESSING, PATTERN RECOGNITION Benign and malignant breast tumors classification based on texture analysis and backpropagation neural network

Breast cancer is a leading cause of death in women due to cancer. According to WHO, in 2018, it is estimated that 627.000 women died from breast cancer, that is approximately 15 % of all cancer deaths among women [3]. Early detection is a very important factor to reduce mortality by 25 – 30 %. Mam-mography is the most commonly used technique in detecting breast cancer using a low-dose X-ray sys-tem in the examination of breast tissue that can reduce false positives. A Computer-Aided Detection (CAD) system has been developed to effectively assist radiologists in detecting masses on mammograms that indicate the presence of breast tumors. The type of abnormality in mammogram images can be seen from the presence of microcalcifications and the presence of mass lesions. In this research, a new approach was developed to improve the performance of CAD System for classifying benign and malignant tumors. Areas suspected of being masses (RoI) in mammogram images were detected using an adaptive thresholding method and mathematical morphological operations. Wavelet decomposition is performed on the Region of Interest (RoI) and the feature extraction process is performed using a GLCM method with 4 statistical features, namely, contrast, correlation, entropy, and homogeneity. Classification of benign and malignant tumors using the MIAS database provided an accuracy of 95.83 % with a sensitivity of 95.23 % and a specificity of 96.49 %. A comparison with other methods illustrates that the proposed method provides better performance.
There’s no place like home: cage odours and place preference in subordinate CD-1 male mice. Physiology & Behavior, 87 (5).

Prior studies using mice have shown that scent marks are an important source of information and can cause behavioural changes in other individuals. Studies have also shown that scent marks in the environment can affect the outcome of social interactions between mice. We used conditioned place preference tests to investigate whether CD-1 male mice ( Mus musculus ) are reinforced by olfactory cues from the home cage. Soiled bedding from the home cage was presented in the initially less preferred chamber of the apparatus to determine whether this association would reduce the unconditioned preference for one chamber over the other. We tested the effects of social rank and housing condition by comparing the performance of dyads that were polarised into dominant and subordinate relationships, both when paired and when separated, with mice that were isolated throughout. The development of conditioned place preference (CPP) supported by home cage odours was influenced by social rank but not by housing condition. Only subordinate mice showed CPP to home cage odours, and this effect was seen irrespective of whether they were housed with a dominant cage mate or alone. Neither dominant (paired or separated) nor isolated mice showed any change in their preference for the chamber associated with home cage odours. This suggests that the smell of home is a more powerful reinforcer for subordinate mice in that it can produce contextual conditioning to the environment in which it is experienced.
MR Imaging of Temporal Evolution of Suprapatellar Plica Synovialis Syndrome: Synovitis, Lipoma Arborescence and Rice Bodies

Synovial plicae are frequently seen in knee joint. Majority of synovial plicae are asymptomatic. Rarely, plicae become thickened and fibrosed, leading to inelasticity, which can snap over the femoral condyle and patella causing synovitis, chondral damage and pain. Hypertrophic and fibrotic plicae are found in 3% of knee arthroscopies and will be the only finding in patients with plica syndrome, most commonly seen with medial plica. Suprapatellar plica syndrome is extremely rare. The authors report the unique MR findings of suprapatellar plica syndrome in five different patients that show the temporal evolution from synovitis to lipoma arborescence and rice bodies.
Pollen Exine Formation

2 *Corresponding authors: Fang Chang 3 4 Address:School of Life Sciences, Fudan University, 5 Shanghai 200438, China 6 Tel:086-021-51630534 7 Fax:086-021-51630504 8 E-mail:fangchang@fudan.edu. cn 9 10 *Corresponding authors: Hong Ma 11 12 Address:School of Life Sciences, Fudan University, 13 Shanghai 200438, China 14 Tel:086-021-51630532 15 Fax:086-021-51630504 16 17 18 19 20 21 22 Plant Physiology Preview. Published on September 21, 2017, as DOI:10.1104/pp.17. 00439
Polarization independent quad‐bandpass frequency selective surfaces with wide‐band ratio

A single layer polarization independent quad‐bandpass frequency selective surface (FSS) with wide‐band ratio is demonstrated theoretically as well as experimentally. The proposed structure passes four frequency bands with wide band ratio. The proposed FSS design is implemented by incorporating alternate arrangement of four units which are rotated 90° clockwise to form a unit cell of metal over a FR4 substrate. The geometrical dimensions of proposed unit cell are optimized and arranged in such a way that the structure possesses the quad bandpass characteristic and aspect dimensions of one unit is 0. 11λ × 0. 11λ with respect to first resonant frequency. This FSS provides stable response for different angle of incidence in transverse electric (TE) mode and transverse magnetic (TM) mode. To validate the results proposed FSS array has been fabricated and measured in free space environment. The measured results are in good agreement with the simulated results. Excellent stability is also observed for different incident angle.
Rough Set Based Method for Vehicle Collision Risk Assessment Through Inferring Driver's Braking Actions in Near-Crash Situations

Driving information and data under potential vehicle crashes create opportunities for extensive real-world observations of driver behaviors and relevant factors that significantly influence the driving safety in emergency scenarios. Furthermore, the availability of such data also enhances the collision avoidance systems (CASs) by evaluating driver? s actions in near-crash scenarios and providing timely warnings. These applications motivate the need for heuristic tools capable of interpreting the correlations of driving risk with driver/vehicle characteristics and incidental traffic factors. In this paper, we acquired amount of real-world field data and built a comprehensive "driver-vehicle-road" dataset for actual driver behavior evaluation. The proposed method works in two steps. In the first step, a variable precision rough set (VPRS) based classifier derives a simplified decision rules from field driving dataset, which presents the essential attributes relevant to driving safety. In the second step, we quantify the mutual information entropy of each attribute to evaluate the significance of different factors on happening a vehicle crash, then an accumulation of weighted "driver-vehicle-road" is calculated to achieve an index reflecting the driving safety level. The performance of the proposed method is demonstrated in an offline analysis of the driving data collected from field trials, where the goal is to infer the emergency braking actions in next short term. The results indicate that our proposed model is a good alternative for providing drivers immediate warnings with high prediction accuracy and stability.
Cyclic AMP in Bacterial Chemotactic Signaling

Defects in phosphotransferase chemotaxis in cya and cpd mutants previously cited as evidence of a cyclic GMP or cyclic AMP intermediate in signal transduction were not reproduced in a study of chemotaxis in Escherichia coli and Salmonella typhimurium. In cya mutants, which lack adenylate cyclase, the addition of cyclic AMP was required for synthesis of proteins that were necessary for phosphotransferase transport and chemotaxis. However, the induced cells retained normal phosphotransferase chemotaxis after cyclic AMP was removed. Phosphotransferase chemotaxis was normal in a cpd mutant of S. typhimurium that has elevated levels of cyclic GMP and cyclic AMP. S. typhimurium crr mutants are deficient in enzyme III5UC1, which is a component of the glucose transport system, and a regulator of adenylate cyclase. After preincubation with cyclic AMP, the crr mutants were deficient in enzyme II,muc°e-mediated transport and chemotaxis, but other chemotactic responses were normal. It is concluded that cyclic GMP does not determine the frequency of tumbling and is probably not a component of the transduction pathway. The only known role of cyclic AMP is in the synthesis of some proteins that are subject to catabolite repression.
Toward Understanding the B[e] Phenomenon. VIII. Nature and Variability of IRAS 07080+0605

We report the results of spectroscopic and photometric observations of the emission-line object IRAS 07080+0605 carried out in 2004–2021. We found that the object is significantly underluminous for its spectroscopic properties (T eff = 8500 ± 500 K, log g = 2.0 ± 0.5), if a strong visual attenuation by a factor of ∼43 found through the spectral energy distribution modeling is not taken into account. Visual brightness variations with a stable period of 190 days but a variable amplitude of ∼0.2 mag were found in the ASAS SN data and attributed to variable circumstellar extinction in the dusty disk. We also found that the observed behavior of IRAS 07080+0605 is similar to that of the protoplanetary nebula Red Rectangle. The dusty disk of IRAS 07080+0605 shows the presence of carbonaceous particles (∼10%–20% of the total dust content) and polycyclic aromatic hydrocarbon emission bands. However, IRAS 07080+0605 shows no obvious signs of the refractory element depletion, which is common in post–asymptotic giant branch (AGB) dusty binaries, or of a visual nebula. Absorption-line positions vary with an amplitude of ∼25 km s−1, suggesting the presence of a secondary component. Spectroscopic monitoring on a timescale from days to months is needed to search for regular variations. We conclude that IRAS 07080+0605 is most likely a binary system with an A-type component on its way toward the post-AGB evolutionary stage, as binarity is capable of explaining most of the observed features.
Lawrence Berkeley National Laboratory Lawrence Berkeley National Laboratory Title Optimization of Sparse Matrix-Vector Multiplication on Emerging Multicore Platforms Permalink

We are witnessing a dramatic change in computer architecture due to the multicore paradigm shift, as every electronic device from cell phones to supercomputers confronts parallelism of unprecedented scale. To fully unleash the potential of these systems, the HPC community must develop multicore specific-optimization methodologies for important scientific computations. In this work, we examine sparse matrix-vector multiply (SpMV) – one of the most heavily used kernels in scientific computing – across a broad spectrum of multicore designs. Our experimental platform includes the homogeneous AMD quad-core, AMD dual-core, and Intel quad-core designs, the heterogeneous STI Cell, as well as one of the first scientific studies of the highly multithreaded Sun Victoria Falls (a Niagara2 SMP). We present several optimization strategies especially effective for the multicore environment, and demonstrate significant performance improvements compared to existing state-of-the-art serial and parallel SpMV implementations. Additionally, we present key insights into the architectural trade-offs of leading multicore design strategies, in the context of demanding memory-bound numerical algorithms.
Metastatic Colon Carcinoma Cell Lines by Interactions in Cytolysis of Primary and Differential Role of Fas/Fas Ligand

We have previously identiﬁed mutated ras peptides reﬂecting the glycine to valine substitution at position 12 as HLA-A2-restricted, CD8 1 CTL neo-epitopes. CTL lines produced against these peptide epitopes lysed the HLA-A2 1 Ag-bearing SW480 primary colon adenocarcinoma cell line, although IFN- g treatment of the targets was necessary to achieve efﬁcient cytotoxicity. Here, we compared the lytic phenotype of the SW480 cell line to its metastatic derivative, SW620, as an in vitro paradigm to further characterize the nature of a HLA class I-restricted, Ag-speciﬁc CTL response against neoplastic cell lines of primary and metastatic origin. Although both colon carcinoma cell lines were lysed by these Ag-speciﬁc CTL following IFN- g pretreatment, the mechanisms of lysis were distinct, which reﬂected differential levels of sensitivity to the Fas pathway. Whereas IFN- g pretreatment rendered SW480 cells sensitive to both Fas-dependent and -independent (perforin) pathways, SW620 cells displayed lytic susceptibility to Fas-independent mechanisms only. Moreover, pretreatment of SW480 cells with the anti-colon cancer agent, 5-ﬂuorouracil (5-FU), led to enhanced Fas and ICAM-1 expression and triggered Ag-speciﬁc CTL-mediated lysis via Fas- and perforin-based pathways. In contrast, these phenotypic and functional responses were not observed with SW620 cells. Overall, these data suggested that 1) IFN- g and 5-FU may enhance the lytic sensitivity of responsive colon carcinoma cells to immune effector mechanisms, including Fas-induced lysis; 2) the malignant phenotype may associate with resistance to Fas-mediated lysis in response to Ag-speciﬁc
Back EMF Estimation-Based Sensorless Control of PMSM: Robustness With Respect to Measurement Errors and Inverter Irregularities

In this paper, the influence of measurement errors and inverter irregularities on the performance of sensorless control is studied. The control algorithm is based on the back-electromotive-force estimation whose robustness with respect to the machine parameter uncertainties has been already studied by supposing that the current measurements and the power stage are ideal. Here, these hypotheses are removed and it is shown, analytically and experimentally, that the control performances at low speeds are highly affected by the imperfection of the electronic components. Finally, the interest of online stator resistance estimation improving the sensorless control performances in spite of the above disturbances is presented
Accelerating OpenMP Applications Through Parallel Hardware Architecture

—It is a well-known fact that application-specific hardware has both performance and power advantages as compared to general-purpose CPUs and GPUs. Furthermore, in order to improve the computing performance leveraging available parallelism in software and hardware, high-level parallel programming paradigms, such as OpenMP and OpenCL, have been viable choices for designing application-specific hardware. In this study, an application-specific parallel hardware architecture with a specialized memory hierarchy is proposed for a class of fork-join applications that can be modeled by an OpenMP program. Furthermore, three different case studies are provided to show how this model can be employed for the hardware acceleration of such applications.
CMAR_A_258230 12527..12534

1Department of Infectious Diseases, The Second Hospital of Dalian Medical University, Dalian 116023, Liaoning, People’s Republic of China; 2Sixth Department of Liver Diseases, The Sixth People’s Hospital of Dalian, Dalian Medical University, Dalian 116031, Liaoning, People’s Republic of China; 3Department of Nephrology, The Third People’s Hospital of Dalian, Dalian 116000, Liaoning, People’s Republic of China