Miracle-dz/UniFAR-FTUs huggingface dataset:
Validation of the Teacher Decision-Making Inventory (TDMI): measuring data-based and intuitive dimensions in teachers' decision Process

Teacher decision making has a great impact on the quality of education in schools, yet we know little about how teachers make decisions in practice. It is assumed that teachers use both intuition and data in the different steps of the decision process. No reliable, valid scales are available to research both dimensions during the different steps of teachers' decision process (problem definition, data collection, sense making, and evaluatioof alternatives). Building on the integratedframework we constructed in earlier research, the main aim of this study was to develop and validate a Teacher Decision-Making Inventory fl'DMI). One hundred and one teachers in adult education participated voluntarily in a web-based survey. Based on the good UFA factor loadings, the CFA fit indices, and the internal consistency (Cronbach's alpha), we conclude that the TDMI is a valid psychometric tool that can be used to assess the intuitive and data-driven dimensions of teachers' decisions in large-scale quantitative research.
Primary analysis from DS8201-A-U105: A phase 1b, two-part, open-label study of trastuzumab deruxtecan (T-DXd) with nivolumab (nivo) in patients (pts) with HER2-expressing urothelial carcinoma (UC).

438 Background: HER2 overexpression has been found in invasive UC, suggesting a role for HER2 in disease progression and prognosis (Kruger Int J Oncol 2002). T-DXd is an antibody-drug conjugate comprising an anti-HER2 antibody, a cleavable linker, and a topoisomerase I inhibitor payload. Preclinical models showed that T-DXd combined with an anti-PD-1 antibody had greater efficacy versus either agent alone (Iwata Mol Cancer Ther 2018). We conducted a phase 1b, 2-part, open-label, multicenter study of T-DXd in combination with nivo in pts with HER2-expressing advanced/metastatic UC (NCT03523572). Methods: Pts aged ≥18 y had pathologically documented advanced/metastatic UC with centrally confirmed HER2 expression by immunohistochemistry (IHC) 2+/3+ (cohort 3; high expression) or IHC 1+ (cohort 4; low expression) who received prior platinum-based therapy with documented progression. Pts received T-DXd at 5.4 mg/kg and nivo 360 mg IV every 3 weeks (recommended dose for expansion). The primary endpoint was confirmed objective response rate (ORR) assessed by independent central review (ICR) per Response Evaluation Criteria in Solid Tumors version 1.1. Secondary endpoints (assessed by ICR) included duration of response (DOR), progression-free survival (PFS), time to response (TTR), and overall survival (OS), and safety. Results: At the primary analysis data cutoff (July 22, 2021), 34 pts (cohort 3, n = 30; cohort 4, n = 4) received T-DXd and nivo. Median age was 70.9 y (range, 41.4-80.5), 88.2% were male, 61.8% received ≥1 prior regimens for locally advanced/metastatic disease, and 26.5% had a history of liver metastases. Median treatment duration (all pts) was 3.2 mo (range, 1-21) for T-DXd and 4.1 mo (range, 1-20) for nivo. In cohort 3, ORR by ICR was 36.7% (95% CI, 19.9-56.1; complete response, 13.3%; partial response, 23.3%), median DOR was 13.1 mo (95% CI, 4.1- NE), median PFS was 6.9 mo (95% CI, 2.7-14.4), median TTR was 1.9 mo (range 1.2-6.9), and median OS was 11.0 mo (95% CI, 7.2-NE). Grade (G) ≥3 treatment-emergent adverse events (TEAEs) occurred in 73.5% of all pts (44.1% related to T-DXd; 26.5% related to nivo). TEAEs leading to drug discontinuation occurred in 32.4% of all pts (17.6% related to T-DXd; 23.5% related to nivo). The most common any-grade TEAEs were nausea (73.5%), fatigue (52.9%), and vomiting (44.1%). Adjudicated drug-related interstitial lung disease (ILD)/pneumonitis occurred in 23.5% of all pts (2 G1; 4 G2; 1 G3; 1 G5). Conclusions: T-DXd combined with nivo showed antitumor activity in pts with high-expressing HER2 UC. The safety profile was consistent with prior studies for T-DXd in other indications and nivo monotherapy in UC pts. Adjudicated ILD/pneumonitis was within the range observed in other T-DXd monotherapy studies. Ongoing clinical trials are further exploring T-DXd in this population. Clinical trial information: NCT03523572.
Compact MIMO/diversity slot antenna for UWB applications with band-notched characteristic

A novel MIMO sharp band-notched antenna with high isolation for UWB applications is presented. The antenna consists of two antenna elements with an overall area of 18 × 36 mm2. A T-shaped stub is extruded in the ground plane to improve isolation and an L-shaped stub to introduce band-notched function C-band (3.62–4.77 GHz). The designed antenna possesses a low mutual coupling of <−20 dB over the operating band from 2.9 to 20 GHz. The performance of this antenna is studied in terms of isolation between the two ports, radiation pattern, efficiency, realised gain, and envelope correlation coefficient.
Practical Application of Urinary Zearalenone Monitoring System for Feed Hygiene Management of a Japanese Black Cattle Breeding Herd—The Relationship between Monthly Anti-Müllerian Hormone and Serum Amyloid A Concentrations

This study addresses an advantageous application of a urinary zearalenone (ZEN) monitoring system not only for surveillance of ZEN exposure at the production site of breeding cows but also for follow-up monitoring after improvement of feeds provided to the herd. As biomarkers of effect, serum levels of the anti-Müllerian hormone (AMH) and serum amyloid A (SAA) concentrations were used. Based on the results of urinary ZEN measurement, two cows from one herd had urinary ZEN concentrations which were two orders of magnitude higher (ZEN: 1.34 mg/kg, sterigmatocystin (STC): 0.08 mg/kg in roughages) than the levels of all cows from three other herds (ZEN: not detected, STC: not detected in roughages). For the follow-up monitoring of the herd with positive ZEN and STC exposure, urine, blood, and roughage samples were collected from five cows monthly for one year. A monitoring series in the breeding cattle herd indicated that feed concentrations were not necessarily reflected in urinary concentrations; urinary monitoring assay by ELISA may be a simple and accurate method that reflects the exposure/absorption of ZEN. Additionally, although the ZEN exposure level appeared not to be critical compared with the Japanese ZEN limitation in dietary feeds, a negative regression trend between the ZEN and AMH concentrations was observed, indicating that only at extremely universal mycotoxin exposure levels, ZEN exposure may affect the number of antral follicles in cattle. A negative regression trend between the ZEN and SAA concentrations could also be demonstrated, possibly indicating the innate immune suppression caused by low-level chronic ZEN exposure. Finally, significant differences (p = 0.0487) in calving intervals between pre-ZEN monitoring (mean ± SEM: 439.0 ± 41.2) and post-ZEN monitoring (349.9 ± 6.9) periods were observed in the monitored five cows. These preliminary results indicate that the urinary ZEN monitoring system may be a useful practical tool not only for detecting contaminated herds under field conditions but also provides an initial look at the effects of long-term chronic ZEN/STC (or other co-existing mycotoxins) exposure on herd productivity and fertility.
Professional Photoshop: The Classic Guide to Color Correction (5th Edition)

The commonsense, by-the-numbers approach of Professional Photoshop has shaped the workflows of a generation of Photoshop experts. This new edition, the first in nearly five years, is completely updated for the age of digital photography. It continues the book's tradition of introducing astoundingly effective, previously unknown methodsi¾ of image enhancement. The original photographs found in the book come from a variety of professional sources, and all correction exercises are on the included CD. Professional Photoshop has changed radically from edition to edition, and this time is no exception-with almost 90 percent new content and completely overhauled coverage of curves, channel blending, and sharpening.Professional Photoshop offers a full explanation of: How curves bring out detail in the most important areas of the imageni¾ A comprehensive strategy for blending channels to create deeper, stronger images The strengths and weaknesses of CMYK, LAB, and RGB, and when to use each one The first detailed look at the Shadow/Highlight command-and even more sophis-ticated ways to enhance contrast in the lightest and darkest parts of the imagen Sharpening strategies, in three full chapters, including the innovative hiraloam method (High Radius, Low Amount). Plus, a fiendishly effective method of merging hiraloam and conventional unsharp masking The realities-and the politics-of preparing files for commercial offset printing and how to deal with colors that are out of the press's gamut What Camera Raw and similar acquisition modules can offer Typical problems of digital captures that were not found in the age of film- and how to correct for them
Can Fraud Triangle Model Predict Fraudulent Financial Statements? Evidence from Egypt

Purpose – The aim of this study is to examine the risk factors of the fraud triangle model, the core of fraud auditing standards, to assessing probability of engaging in fraudulent financial statements. Design/Method – Depending on logistic regression analysis, this study examined the impact of the elements of fraud triangle model on the detection of financial frauds in financial statements. Significant variables, relating to pressure, opportunity and rationalization are investigated. Findings – this study found that fraud risk factors for pressure (financial leverage and sales to total assets), for opportunity (independence of audit committee), and for rationalization (total accruals) are significantly associated to the occurrence of fraudulent financial statements.
Evaluation of formation and health risks of disinfection by-products in drinking water supply of Ggaba waterworks, Kampala, Uganda.

In developing countries, the evaluation of disinfection by-products in drinking water has been neglected because most water utility companies focus on microbial elimination. As a result, this study aimed at evaluating trihalomethane formation, the relation between water quality parameters and trihalomethane formation, and the estimation of the associated potential health risks in drinking water. The headspace purge and trap coupled with a gas chromatography-mass spectrometry technique was used to quantify trihalomethane. The concentrations of trihalomethane found in the water were within the National Water and Sewerage Corporation, World Health Organization guidelines, and the United States Environmental Protection Agency standards. Total organic carbon, ultraviolet absorbance at 254 nm, bromide concentration, and the temperature had a positive and significant correlation, pH had a positive but non-significant correlation, while the residual chlorine had a negative but significant correlation with trihalomethane formation. The potential health risk using the WHO index was 0.4, indicating no noncarcinogenic risk to human health in the study area. The lifetime carcinogenic risks of trihalomethane due to oral ingestion, dermal, and inhalation were 2.5×10-5, 9.1×10-6, and 8.3×10-6 for females and 2.4×10-5, 1×10-5, and 7.9×10-6 for males, and the values were within the USEPA acceptable low-risk range of 1×10-6
Strengthening the public downstream SLD supply chain for MDR-TB : lessons learnt from a Western Cape case study

Strengthening the public downstream SLD supply chain for MDR-TB: Lessons learnt from a Western Cape Case Study E. Coetzee Department of Industrial Engineering, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa. Thesis: MEng (Industrial) 2015 Systemic problems in the supply chain of second-line anti-TB drugs (SLDs) for multidrug-resistant tuberculosis (MDR-TB) are well documented and contribute significantly to the difficulties preventing successful control of the disease. Though literature contains a wealth of proposed changes to global SLD supply chain policies, there is a significant research gap related to quantitative modelling of the SLD supply chain to accurately predict the expected impact of these proposed changes on the availability and delivery of SLDs. The global SLD supply chain consists of two components: (i) the “upstream” component which includes all activities from the manufacturing of the active pharmaceutical ingredient through to the warehousing of drugs prior to shipment; and (ii) the “downstream” component which includes in-country warehousing and delivery of drugs to various healthcare facilities. In this research study, a downstream SLD supply chain is modelled using real-world data. The model is built for one SLD used in the MDR-TB treatment regimen, namely amikacin. This research forms part of a bigger study that will eventually incorporate both the upstream and the downstream components of the supply chain into a single model. A model of the current downstream segment of the supply chain for SLDs in the Western Cape was developed using a System Dynamics modelling approach. The model has been built and validated using real-world data provided by the Western Cape Department of Health (WCDoH). This model has been used as a platform for: (i) studying the behaviour and stability of the downstream component of the global SLD supply chain; and (ii) testing the ii Stellenbosch University https://scholar.sun.ac.za
EOL-BHL-NESCent Research Sprint Report

There are exciting biological questions which require programming and large online data resources to address, yet many traditionally-trained biologists lack the informatics skills needed for successful analysis. In the last decade, new aggregated, open data resources have become available, but these are not often being leveraged effectively for big data research. Using a new hackathon-inspired format, the EOL-BHL-NESCent Research Sprint facilitated scientific discovery by supporting teams to use online data resources such as the Encyclopedia of Life and Biodiversity Heritage Library to answer their biological questions. We describe the methods of the research sprint and present results indicating its success in producing publications, in introducing scientists to large-scale informatics resources and approaches, and in encouraging new collaborations.
Stochastic Programming Model for Elective Surgery Planning: An Effect of Emergency Surgery

: This paper introduces a stochastic programming model for a hospital with two surgery types: elective and emergency surgeries. We propose a model that decides the number of the elective surgeries per day according to a scheme that makes best use of the operating rooms. Speciﬁcally, we model when the demand capacity for emergency surgery in the operating room of one day is uncertain. We created multiple surgery times, performed random sampling, and conducted numerical experiments. In the results, emergency surgery changed the allocation of elective surgery. In this paper, we report on the proposed model and numerical results, and discuss these and the future research prospects.
The Risk of Adverse Effects of TNF-α Inhibitors in Patients With Rheumatoid Arthritis: A Network Meta-Analysis

Objectives To evaluate the safety of each anti-TNF therapy for patients with rheumatoid arthritis (RA) and then make the best choice in clinical practice. Methods We searched PUBMED, EMBASE, and the Cochrane Library. The deadline for retrieval is August 2021. The ORs, Confidence Intervals (CIs), and p values were calculated by STATA.16. 0 software for assessment. Result 72 RCTs involving 28332 subjects were included. AEs were more common with adalimumab combined disease-modifying anti-rheumatic drugs (DMARDs) compared with placebo (OR = 1.60, 95% CI: 1.06, 2.42), DMARDs (1.28, 95% CI: 1.08, 1.52), etanercept combined DMARDs (1.32, 95% CI: 1.03, 1.67); certolizumab combined DMARDs compared with placebo (1.63, 95% CI: 1.07, 2.46), DMARDs (1.30, 95% CI: 1.10, 1.54), etanercept combined DMARDs (1.34, 95% CI: 1.05, 1.70). In SAEs, comparisons between treatments showed adalimumab (0.20, 95% CI: 0.07, 0.59), etanercept combined DMARDs (0.39, 95% CI: 0.15, 0.96), golimumab (0.19, 95% CI: 0.05, 0.77), infliximab (0.15, 95% CI: 0.03,0.71) decreased the risk of SAEs compared with golimumab combined DMARDs. In infections, comparisons between treatments showed adalimumab combined DMARDs (0.59, 95% CI: 0.37, 0.95), etanercept (0.49, 95% CI: 0.28, 0.88), etanercept combined DMARDs (0.56, 95% CI: 0.35, 0.91), golimumab combined DMARDs (0.51, 95% CI: 0.31, 0.83) decreased the risk of infections compared with infliximab combined DMARDs. No evidence indicated that the use of TNF-α inhibitors influenced the risk of serious infections, malignant tumors. Conclusion In conclusion, we regard etanercept monotherapy as the optimal choice for RA patients in clinical practice when the efficacy is similar. Conversely, certolizumab + DMARDs therapy is not recommended. Systematic Review Registration identifier PROSPERO CRD42021276176.
Dietary Outcomes, Nutritional Status and Household WASH Practices

The Government of Ethiopia has made a major commitment toward improving food security, diet, nutrition, and health through a series of national nutrition plans. The focus of these plans is on providing both nutrition specific as well as nutrition sensitive approaches for achieving national priorities for health and nutrition. The present study conducted a secondary analysis of data provided through a larger birth cohort study conducted in Ethiopia between 2014 and 2016. The overall objectives of this research were to assess the relationship between minimum dietary diversity in women and Water, Sanitation and Hygiene (WASH), and evaluate the association between mid-upper arm circumference (MUAC) in women and WASH. In addition to descriptive statistics, the study used mixed effects logistic regression analyses to investigate the relationship between dietary diversity, MUAC and household WASH practices. Improved WASH practices were associated with an increased probability (P = .0.040) that a woman would consume a diet with foods from five or more food groups. A beneficial effect was observed for improved WASH practices and a decrease in low MUAC. Improved household WASH practices were successful in contributing to improved dietary diversity in women as well as an improved MUAC. Interventions aimed at improving the diet and nutritional status of women during and after pregnancy should include relevant WASH components as essential elements in multi-sector nutrition programming.
Planning Strategy for an Electric Vehicle Fast Charging Service Provider in a Competitive Environment

Fast charging is a promising method of energy refueling for electric vehicles (EVs), significantly shortening the refueling time to a level comparable with traveling and queuing times, which consequently will highly influence the decision of charging places for EV users. Multiple charging service providers (CSPs) are participating in the investment of EV fast charging facilities, inevitably bringing competition among each other, which affects the planning decision of investors. This paper studies the planning strategy of EV fast charging infrastructure in a competitive environment, taking the queuing impacts on EV users into consideration. A double-loop iterative methodology is proposed, and the outer loop seeks the equilibrium point of the CSP’s planning schemes. A user equilibrium traffic assignment model integrated with queuing theory and an adaptive route selection algorithm are built in the inner loop to optimize the planning scheme of a CSP, along with a station-level linear programming model to obtain the optimal sizes and operation scheduling of on-site ESSs considering time-of-use prices and investment constraints. Case studies verify the effectiveness of the proposed method and reveal that ignoring the competitors’ response will cause overestimation of the CSP’s attracted charging demands and its total benefits.
Ethics behind Leadership in Different Economies

Leadership has been defined as a methodology of social influence in which one individual can engage the aid and the support of others in the achievement of a typical task. For instance, some comprehend a leader essentially as someone whom individuals take after or as someone who guides or motivates individuals, while others characterize leadership as “arranging a group of individuals to attain a typical objective and achieve mutual objectives”. Leadership studies have created several types of theories including traits, function, power, situational interaction, vision, behavior, intelligence and charisma. For instance, the leadership Grid is a situational leadership which is based on two behavioral dimensions—concern for production, plotted on the X-axis on a scale from one to nine points; and concern for people, plotted on a similar scale along the Y-axis. The model proposes that the team leadership style, which displays a high degree of concern for both production and people, may boost employee productivity. This paper addresses Ethics in Leadership and how ethical and unethical leaders affect the performance of employees and addresses at the same time the impact of leadership behavior in different economics whether static or dynamic.
ImpressionNet: A Multi-view Approach to Predict Socio-facial Impressions

: The visual facial features do reveal a lot about an individual and can be used to analyse several important social attributes. Existing works have shown that it is possible to learn these attributes through computational models and classify or score subject-faces accordingly. However, we ﬁnd that there exists local variance in perception. There could be different perspectives of the face which the conventional methods fail to efﬁciently capture. We also note that Deeper neural networks usually require enough training data and add little to no improvement upon existing ones. In this work, we take social attribute prediction a notch higher and propose a novel multi-view regression approach to incorporate multiple views of face inspired by multi-modal learning. Experimental results show that the proposed approach can achieve superior feature generalisation and diversiﬁcation on existing datasets using multiple views to improve the coefﬁcient of determination scores and outperforms the state-of-the-art social attribute prediction method. We further propose a method that enables real-time video analysis of multiple subject faces which can have several applications.
NGF/TRKA Promotes ADAM17-Dependent Cleavage of P75 in Ovarian Cells: Elucidating a Pro-Tumoral Mechanism

Nerve growth factor (NGF) and its high-affinity receptor TRKA are overexpressed in epithelial ovarian cancer (EOC) displaying a crucial role in the disease progression. Otherwise, NGF interacts with its low-affinity receptor P75, activating pro-apoptotic pathways. In neurons, P75 could be cleaved by metalloproteinases (α and γ-secretases), leading to a decrease in P75 signaling. Therefore, this study aimed to evaluate whether the shedding of P75 occurs in EOC cells and whether NGF/TRKA could promote the cleavage of the P75 receptor. The immunodetection of the α-secretase, ADAM17, TRKA, P75, and P75 fragments was assessed by immunohisto/cytochemistry and Western blot in biopsies and ovarian cell lines. The TRKA and secretases’ inhibition was performed using specific inhibitors. The results show that P75 immunodetection decreased during EOC progression and was negatively correlated with the presence of TRKA in EOC biopsies. NGF/TRKA increases ADAM17 levels and the fragments of P75 in ovarian cells. This effect is abolished when cells are previously treated with ADAM17, γ-secretase, and TRKA inhibitors. These results indicate that NGF/TRKA promotes the shedding of P75, involving the activation of secretases such as ADAM17. Since ADAM17 has been proposed as a screening marker for early detection of EOC, our results contribute to understanding better the role of ADAM17 and NGF/TRKA in EOC pathogenesis, which includes the NGF/TRKA-mediated cleavage of P75.