Miracle-dz/UniFAR-FTUs huggingface dataset:
The impact of probiotics on gut microbiota and non-alcoholic fatty liver disease (NAFLD) progression based on controlled attenuated parameter (CAP) elastography: Randomized controlled trial

Background: The gut–liver axis has many implications in non-alcoholic fatty liver disease onset as the major contributor of intestinal dysbiosis. Gut microbiota have an important role in intestinal barrier function and reversal of leaky gut. Probiotics may restore intestinal barrier integrity and contribute to hepatic functions recovery and alleviating inflammatory and fibrogenic processes. We aimed to evaluate the impact of probiotics on gut microbiota and non-alcoholic fatty liver disease progression. Results: Sixty non-alcoholic fatty liver disease patients (30 non-alcoholic fatty liver and 30 non-alcoholic steatohepatitis patients) were included in this open label randomized controlled study. Half of the patients of each group were randomized to receive probiotics in addition to classic management. The patients were followed-up for 6 months. The non-alcoholic fatty liver disease patients in the probiotic group experienced significant improvement in their Alanine aminotransferase, triglycerides, liver steatosis, and fibrosis stages, fecal pathological bacterial growth and Lactobacillus acidophilus abundance (P= 0.05, 0.029, 0.012, 0.013, 0.034, <0.001 and 0.005 respectively). Waist circumference and low density lipoprotein improvements were more pronounced in non-alcoholic fatty liver patients. Conclusion: Adding probiotic therapy to classical management of non-alcoholic fatty liver disease may help in improving intestinal dysbiosis, liver steatosis and fibrosis.
Characterization of Pt∕SrBi2Ta2O9∕Hf–Al–O∕Si field-effect transistors at elevated temperatures

Temperature dependence of electrical properties is studied statistically from 24 p-channel Pt∕SrBi2Ta2O9∕Hf–Al–O∕Si field-effect transistors up to 85°C. They show consistent properties and the distribution of threshold voltage is narrow. The memory window decreases from 1.40to1. 15V as temperature increases from 27to85°C. Retention is characterized at zero bias voltage. The on-/off-state drain current ratios are above 105 at 27°C and nearly 104 at 85°C after more than 105s of measurement, respectively. These results are promising for future circuit integration of ferroelectric nonvolatile memories.
Non-Singular Modified Gravity Unifying Inflation with Late-Time Acceleration and Universality of Viscous Ratio Bound in F(R) Theory(Chapter III: Testing general relativity and modifiled gravity theory,Cosmology-The Next Generation-)

singularities in such theories via the introduction of R 2 -term is studied. New realistic nonsingular F (R)-gravity unifying early-time inflation with late-time acceleration is presented. The exit from inflationary era in such model may be caused by the gravitational scenario. It is demonstrated that five-dimensional F (R)-gravity considered as non-perturbative stringy effective action leads to universal relation for viscous bound ratio.
Literary Review of the Treatment of Arterial Hypertension by Traditional Medicine

not always Abstract: Hypertension is one of the most urgent problems of modern medicine today. Supporters of folk or any other ways of treating hypertension, of course, have every right to be enthusiasts of their methods, especially if they are based on the harmony of the regime of work and rest, diet, rational nutrition, adequate physical activity. To date, not only modern methods of diagnosis and treatment are being developed, but also their combined use with traditional medicine. transcerebralmagnetic morphofunctional state of microvessels in patients with hypertension. an action to a favorable restructuring of the mechanisms of regulation of magnetic circulation: the dominant influence of active modulators (endothelial and vasomotor) is formed against the background of a decrease in (pulse and respiratory positive effect the psycho-emotional normalizing effect on the autonomic supply of cardiovascular tone; modulating effect on central and peripheral hemodynamics; corrective vascular endothelial dysfunction and adrenergic vascular reactivity; of self-regulating non-specific adaptive systems of the pathogenetically substantiated use of forms of hypertension, dosimetric therapeutic physical
Virtual Reality

Virtual reality represents both the hope and the hype of computer science. With its promise of providing highly interactive and responsive interfaces to computer applications, virtual reality suffers from a media blitz that threatens its success before it becomes reality. The term virtual reality conjures up notions of science fiction in many people's minds. Despite an abundance of hype, virtual reality is slowly emerging as an important new way of interacting with computer applications and simulations. Virtual reality is an attempt to provide an interactive, immersive interface to a synthetic, computer-generated world. It is the logical extension and coupling of recent progress in the fields of computer graphics and human-computer interaction (HCI). In the following discussions, we will attempt to separate the fiction of virtual reality from the science. In addition to providing a general introduction to virtual reality, we will focus on current technology and techniques as well as future possibilities. Discussions include history, display devices, interaction devices, design tools, and applications. Before delving into the details and technology of virtual reality, let us first consider what we mean by the term virtual reality.
ULTRALUMINOUS X-RAY SOURCES IN NEARBY GALAXIES: CLUES ON THEIR NATURE FROM X-RAY TIMING AND NEW OPTICAL DATA

A protective garment, such as a surgeon's glove, is monitored for the occurrence of a breach in that garment. The monitoring is performed using an improved version of the system disclosed in U.S. Pat. No. 5,036,309, issued Jul. 30, 1991. The system is improved by adding monitors for ensuring that contacts are in proper and secure electrical contact with both the worker and the workpiece. The system is further improved by adding electrical buses so that further contact monitors and garment integrity monitors can be added to the basic system and a start-up system integrity checking system. All monitors include current amplifying elements, such as transistors.
Age‐related decrease in periostin expression may be associated with attenuated fracture healing in old mice

Older adults suffer more bone fractures with higher rates of healing complications and increased risk of morbidity and mortality. An improved understanding of the cellular and molecular mechanism of fracture healing and how such processes are perturbed with increasing age may allow for better treatment options to manage fractures in older adults. Macrophages are attractive therapeutics due to their role in several phases of fracture healing. After injury, bone marrow–derived macrophages are recruited to the injury and propagate the inflammatory response, contribute to resolution of inflammation, and promote bone regeneration. A tissue resident population of macrophages named osteal macrophages are present in the periosteum and are directly associated with osteoblasts and these cells contribute to bone formation. Here, we utilized bulk RNA sequencing to analyze the transcriptional activity of osteal macrophages from old and young mice present in primary calvarial cultures. Macrophages demonstrated a diverse transcriptional profile, expressing genes involved in immune function as well as wound healing and regeneration. Periostin was significantly downregulated in macrophages from old mice compared to young. Periostin is an extracellular matrix protein with important functions that promote osteoblast activity during bone regeneration. An age‐related decrease of periostin expression was verified in the fracture callus of old mice compared to young. Young periostin knockout mice demonstrated attenuated fracture healing outcomes that reflected what is observed in old mice. This study supports an important role of periostin in fracture healing, and therapeutically targeting the age‐related decrease in periostin may improve healing outcomes in older populations.
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Background and Aims: Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis. Mechanisms and downstream signaling remain incompletely understood. Here, we studied the role of IL‐18 in hepatic stellate cells (HSCs), and its impact on liver fibrosis. Approach and Results: We observed significantly increased serum levels of IL‐18 (128.4 pg/ml vs. 74.9 pg/ml) and IL‐18 binding protein (BP; 46.50 ng/ml vs. 15.35 ng/ml) in patients with liver cirrhosis compared with healthy controls. Single cell RNA sequencing data showed that an immunoregulatory subset of murine HSCs highly expresses Il18 and Il18r1. Treatment of cultured primary murine HSC with recombinant mouse IL‐18 accelerated their transdifferentiation into myofibroblasts. In vivo, IL‐18 receptor‐deficient mice had reduced liver fibrosis in a model of fibrosis induced by HSC‐specific NLRP3 overactivation. Whole liver RNA sequencing analysis from a murine model of severe NASH‐induced fibrosis by feeding a choline‐deficient, L‐amino acid‐defined, high fat diet showed that genes related to IL‐18 and its downstream signaling were significantly upregulated, and Il18 −/− mice receiving this diet for 10 weeks showed protection from fibrotic changes with decreased number of alpha smooth muscle actin‐positive cells and collagen deposition. HSC activation triggered by NLRP3 inflammasome activation was abrogated when IL‐18 signaling was blocked by its naturally occurring antagonist IL‐18BP. Accordingly, we observed that the severe inflammatory phenotype associated with myeloid cell‐specific NLRP3 gain‐of‐function was rescued by IL‐18BP. Conclusions: Our study highlights the role of IL‐18 in the development of liver fibrosis by its direct effect on HSC activation identifying IL‐18 as a target to treat liver fibrosis.
Investigation of oxidative damage, antioxidant balance, DNA repair genes, and apoptosis due to radiofrequency-induced adaptive response in mice

ABSTRACT This study aims to determine whether exposure to non-ionizing radiofrequency fields could induce an adaptive response (AR) in adult mice and to reveal potential molecular mechanisms triggered by RF-induced AR. The study was performed on 24 adult male Swiss-Albino mice. The average mass of the mice was 37 g. Four groups of adult mice, each consisting of 6, were formed. The radiofrequency group (R) and the adaptive response group (RB) were exposed to 900 MHz of global system for mobile communications (GSM) signal at 0.339 W/kg (1 g average specific absorption rate) 4 h/day for 7 days, while the control group (C) and the bleomycin group (B) were not exposed. 20 minutes after the last radiofrequency field (RF) exposure, the mice in the B and RB groups were injected intraperitoneal (ip) bleomycin (BLM), 37.5 mg/kg. All the animals were sacrificed 30 minutes after the BLM injection. Oxidative damage and antioxidant mechanism were subsequently investigated in the blood samples. Changes in the expression of the genes involved in DNA repair were detected in the liver tissue. TUNEL method was used to determine the apoptosis developed by DNA fragmentation in the liver tissue. The RB group, which produced an adaptive response, was compared with the control group. According to the results, the increase of reactive oxygen species (ROS) in the RB group may have played an important role in triggering the adaptive response and producing the required minimum stress level. Furthermore, tumor suppressor 53(p53), oxo guanine DNA glycosylase (OGG-1) levels responsible for DNA repair mechanism genes expression were increased in conjunction with the increase in ROS. The change in the poly (ADP-ribose) polymerase 1 (PARP-1) and glutathione peroxidase 1 (GPx-1) gene expression were not statistically significant. The antioxidant enzyme levels of superoxide dismutase (SOD), catalase (CAT), and total antioxidant capacity (TAC) were decreased in the group with adaptive response. According to the data obtained from terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) analysis, apoptosis was decreased in the RB group due to the decrease in cell death, which might have resulted from an increase in gene expression responsible for DNA repair mechanisms. The results of our study show that exposure to RF radiation may create a protective reaction against the bleomycin. The minimal oxidative stress due to the RF exposure leads to an adaptive response in the genes that play a role in the DNA repair mechanism and enzymes, enabling the survival of the cell.
Where to draw the line? The influence of prior relationship, perpetrator‐target sex and perpetrator motivation on the point at which behavior ‘crosses the line’ and becomes stalking

Abstract The present study examines the influence of prior relationship (intimate, non‐intimate), perpetrator‐target sex (male‐female, female‐male) and perpetrator motivation (romance, upset) on (1) the point at which behavior crosses the line and becomes stalking, and (2) the likelihood of offering five forms of advice to the target (formal support, informal support, protective measures, avoidance measures, threatening action). The study used a 2 × 2 × 2 between‐participants experimental design. Four‐hundred and sixty‐one UK students read one of eight versions of a hypothetical scenario that they were informed may or may not depict a stalking situation. Analyses revealed that 97.8% (n = 451) of participants believed the perpetrator's behavior constituted stalking, and that behavior was perceived to cross the line earlier in the scenario when the perpetrator's motivation was to upset the target in the context of a non‐intimate prior relationship only. Prior relationship, perpetrator‐target sex and perpetrator motivation also influenced the likelihood of offering various forms of advice to the target. These findings further demonstrate the impact of situational characteristics on perceptions of stalking and highlight the importance of educational campaigns and programs to increase people's understanding of stalking.
Population pharmacokinetic/pharmacodynamic study suggests continuous infusion of ceftaroline daily dose in ventilated critical care patients with early-onset pneumonia and augmented renal clearance

Abstract Objectives Ceftaroline could be suitable to treat early-onset ventilator-associated pneumonia (VAP) because of its antibacterial spectrum. However, augmented renal clearance (ARC) is frequent in ICU patients and may affect ceftaroline pharmacokinetics and efficacy. The objective of the study was to explore the impact of ARC on ceftaroline pharmacokinetics and evaluate whether the currently recommended dosing regimen (600 mg every 12 h) is appropriate to treat VAP in ICU patients. Methods A population pharmacokinetic model was developed using pharmacokinetic data from 18 patients with measured creatinine clearance (CLCR) ranging between 83 and 309 mL/min. Monte Carlo simulations were conducted to determine the PTA and the cumulative fraction of response (CFR) against Streptococcus pneumoniae and MRSA for five dosing regimens. Study registered at ClinicalTrials.gov (NCT03025841). Results Ceftaroline clearance increased non-linearly with CLCR, with lower concentrations and lower probability of reaching pharmacokinetic/pharmacodynamic targets when CLCR increases. For the currently recommended dosing regimen, the probability of having unbound ceftaroline concentrations above the MIC over the entire dose range is greater than 90% for MICs below 0.125 mg/L. Considering the distribution of MICs, this regimen would not be effective against MRSA infections (CFR between 21% and 67% depending on CLCR), but would be effective against S. pneumoniae infections (CFR >86%). Conclusions The recommended dosing regimen of ceftaroline seems sufficient for covering S. pneumoniae in ICU patients with ARC, but not for MRSA. Among the dosing regimens tested it appears that a constant infusion (50 mg/h) after a loading dose of 600 mg could be more appropriate for MRSA infections.
Sex‐specific behavioral, neurobiological, and cardiovascular responses to chronic social stress in mice

Psychosocial stress promotes and links mood and cardiovascular disorders in a sex‐specific manner. However, findings in animal models are equivocal, in some cases opposing human dimorphisms. We examined central nervous system (CNS), behavioral, endocrine, cardiac, and hepatic outcomes in male or female C57Bl/6 mice subjected to chronic social stress (56 days of social isolation, with intermittent social confrontation encounters twice daily throughout the final 20 days). Females exhibited distinct physiological and behavioral changes, including relative weight loss, and increases in coronary resistance, hepatic inflammation, and thigmotaxic behavior in the open field. Males evidence reductions in coronary resistance and cardiac ischemic tolerance, with increased circulating and hippocampal monoamine levels and emerging anhedonia. Shared CNS gene responses include reduced hippocampal Maoa and increased Htr1b expression, while unique responses include repression of hypothalamic Ntrk1 and upregulation of cortical Nrf2 and Htr1b in females; and repression of hippocampal Drd1 and hypothalamic Gabra1 and Oprm in males. Declining cardiac stress resistance in males was associated with repression of cardiac leptin levels and metabolic, mitochondrial biogenesis, and anti‐inflammatory gene expression. These integrated data reveal distinct biological responses to social stress in males and females, and collectively evidence greater biological disruption or allostatic load in females (consistent with propensities to stress‐related mood and cardiovascular disorders in humans). Distinct stress biology, and molecular to organ responses, emphasize the importance of sex‐specific mechanisms and potential approaches to stress‐dependent disease.
Line-feature-based SLAM Algorithm

A line-feature based SLAM algorithm is presented in this paper to resolve the conflict between the requirements of computational complexity and information-richness within the point-feature based SLAM algorithm, All operations required for building and maintaining the map, such as model-setting, data association, and state-updating, are described and formulated. This approach has been programmed and successfully tested in the simulation work, and results are shown at the end of this paper.
Non‐coding RNAs in diseases with a focus on osteoarthritis

Osteoarthritis (OA) is a frequent musculoskeletal disorder affecting millions of people worldwide. Despite advances in understanding the pathogenesis of OA, prognostic biomarkers or effective targeted treatment are not currently available. Research on epigenetic factors has yielded some new insights as new technologies for their detection continue to emerge. In this context, non‐coding RNAs, including microRNAs, long non‐coding RNAs, circular RNAs, piwi‐interacting RNAs, and small nucleolar RNAs, regulate intracellular signaling pathways and biological processes that have a crucial role in the development of several diseases. In this review, we present current knowledge on the role of epigenetic factors with a focus on non‐coding RNAs in the development, prediction and treatment of OA.
Acute macular neuroretinopathy in a patient with birdshot chorioretinopathy after intravitreal triamcinolone suspension injection

Purpose To report a case of acute macular neuroretinopathy (AMN) after intravitreal triamcinolone acetonide (TRIESENCE®) injection for cystoid macular edema secondary to birdshot chorioretinopathy. Method A case report. Patient A 62-year-old female. Results The patient presented with acutely decreased vision and a ring scotoma around her central vision three days after intravitreal triamcinolone acetonide (TRIESENCE®) injection for cystoid macular edema in her right eye (OD) secondary to birdshot chorioretinopathy. She had undergone pars plana vitrectomy, cataract extraction, and secondary intraocular lens implantation OD three months prior to the recent injection. Best-corrected visual acuity (BCVA) was 20/1000 OD and 20/50 OS. Intraocular pressure was 21 mmHg OD and 12 mmHg OS. Fluorescein angiography demonstrated a hypofluorescent area in the perifoveal zone OD. Optical coherence tomography OD depicted hyperreflective areas in the outer nuclear layer, outer plexiform layer, and retinal pigment epithelium. We diagnosed her with AMN OD and started her on brimonidine three times a day OD. She came back a week later with resolved scotoma and her vision improved to 20/60 OD. Five weeks later, BCVA was 20/40 and Intraocular pressures (IOP) was 12 mmHg OD. Conclusions and importance Intravitreal triamcinolone injection may be a cause of AMN with cystoid macular edema (CME) and borderline-high intraocular pressure. Brimonidine may be an effective treatment for these patients in the early course of the disease.
Social Anxiety and Social Networking Service Addiction Proneness in University Students: The Mediating Effects of Experiential Avoidance and Interpersonal Problems

Social networking service (SNS) refers to an online service established for the purpose of sharing specific interests or activities by forming social relationships based on a wide human network online.1 The use of SNS is rapidly increasing among all generations, and the use rate of university students (95.9%) is the highest.2 The university student period emphasizes social relationships and has the developmental task of forming close interpersonal relationships.3 The active use of SNS by university students can be understood as a natural phenomenon in that the use of SNS can help form close interPrint ISSN 1738-3684 / On-line ISSN 1976-3026 OPEN ACCESS
Barriers and facilitators to mental healthcare for women veterans: a scoping review

Abstract Background Traditionally, veteran research and support have centred on the requirements of a predominantly male population. However, as female participation in the Armed Forces increases and their roles diversify, consideration of women’s unique mental health needs is imperative. Women veterans are at greater risk of post-service mental health challenges than their male counterparts, and female mental health outcomes have deteriorated in recent years. Aims To determine the provenance of these outcomes, a scoping review considering both barriers and facilitators to female veteran participation in mental health services was conducted. Methods A review was carried out following the 2020 Joanna Briggs Institute Scoping Review framework. Twenty-four papers were identified, with all but one originating from the US. Results This research indicated that whilst women experience barriers common to male veterans (e.g. help-seeking stigma), they also experience unique gender-specific barriers to accessing mental healthcare services (e.g. lack of gender-sensitive treatment options, feeling uncomfortable) and such barriers result in under-utilization of services. Conclusions Literature indicates that consideration and mitigation of these barriers might improve access and health outcomes for women veterans. Further research is required outside the US to understand the barriers to mental healthcare experienced by women veterans internationally.