Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing Ambient Assisted Living Support for Patients with Mild Cognitive Impairment: Results supported by a questionnaire applied to several healthcare stakeholders

According to the World Health Organization, about 50 million people worldwide suffer from dementia. Ten million new cases added every year [1]. Mild Cognitive Impairment (MCI) affects more than 15% of the population aged 65. MCI patients are mostly home-based. Ambient Assisted Living (AAL) systems provide tools for automatic registration of vital signs and other medically and socially important information. An online anonymous questionnaire for healthcare professionals was created to prove or disprove the number of interconnected hypotheses about the necessity and feasibility of the AAL system for MCI patients. The questionnaire was completed by sixty respondents. Descriptive statistics show support for the implementation of general AAL and variants for MCI patients. Comparative analysis of ordinal data groups is done with help of the non-parametric Mann–Whitney–Wilcoxon test and the Kruskal-Wallis test. Table questions results are analyzed with chi-square for frequency tables. Comparative analysis of groups demonstrated relative uniformity of responses.
Universals of Linguistic Idiosyncrasy in Multilingual Computational Linguistics (Dagstuhl Seminar 21351)

Computational linguistics builds models that can usefully process and produce language and that can increase our understanding of linguistic phenomena. From the computational perspective, language data are particularly challenging notably due to their variable degree of idiosyncrasy (unexpected properties shared by few peer objects), and the pervasiveness of non-compositional phenomena such as multiword expressions (whose meaning cannot be straightforwardly deduced from the meanings of their components, e.g. red tape, by and large, to pay a visit and to pull one’s leg) and constructions (conventional associations of forms and meanings). Additionally, if models and methods are to be consistent and valid across languages, they have to face specificities inherent either to particular languages, or to various linguistic traditions. These challenges were addressed by the Dagstuhl Seminar 21351 entitled “Universals of Linguistic Idiosyncrasy in Multilingual Computational Linguistics”, which took place on 30-31 August 2021. Its main goal was to create synergies between three distinct though partly overlapping communities: experts in typology, in cross-lingual morphosyntactic annotation and in multiword expressions. This report documents the program and the outcomes of the seminar. We present the executive summary of the event, reports from the 3 Working Groups and abstracts of individual talks and open problems presented by the participants.
ANALYSIS OF AC CONTACTORS COMBINING ELECTRIC CIRCUITS, TIME-HARMONIC FINITE ELEMENT SIMULATIONS AND EXPERIMENTAL WORK

The paper addresses complementary approaches to the calculation of electromagnetic parameters of an industrial alternating current (AC) contactor rated for 220 volts and 60 hertz. The methods of analysis include conventional electric circuits derived from measurements of terminal characteristics. The duality between interlinked electric and magnetic circuits is employed to calculate the contactor’s magnetizing reactance during a locked closing maneuver and during the closed-core configuration. The parameters obtained from the circuit analyses are compared to the more precise estimates of finite element analyses. Special attention is given to the subtle differences of circuit properties applied to the conductive regions containing driving currents as well as to regions where current is actually induced due to time variation of the magnetic flux. Attempt is made to facilitate the understanding of the physical phenomena related to the presence of eddy currents in the shading rings.
Seasonal Evolution of Supraglacial Lakes on Baltoro Glacier From 2016 to 2020

The existence of supraglacial lakes influences debris-covered glaciers in two ways. The absorption of solar radiation in the water leads to a higher ice ablation, and water draining through the glacier to its bed leads to a higher velocity. Rising air temperatures and changes in precipitation patterns provoke an increase in the supraglacial lakes in number and total area. However, the seasonal evolution of supraglacial lakes and thus their potential for influencing mass balance and ice dynamics have not yet been sufficiently analyzed. We present a summertime series of supraglacial lake evolution on Baltoro Glacier in the Karakoram from 2016 to 2020. The dense time series is enabled by a multi-sensor and multi-temporal approach based on optical (Sentinel-2 and PlanetScope) and Synthetic Aperture Radar (SAR; Sentinel-1 and TerraSAR-X) remote sensing data. The mapping of the seasonal lake evolution uses a semi-automatic approach, which includes a random forest classifier applied separately to each sensor. A combination of linear regression and the Hausdorff distance is used to harmonize between SAR- and optical-derived lake areas, producing consistent and internally robust time series dynamics. Seasonal variations in the lake area are linked with the Standardized Precipitation Index (SPI) and Standardized Temperature Index (STI) based on air temperature and precipitation data derived from the climate reanalysis dataset ERA5-Land. The largest aggregated lake area was found in 2018 with 5.783 km2, followed by 2019 with 4.703 km2, and 2020 with 4.606 km2. The years 2016 and 2017 showed the smallest areas with 3.606 and 3.653 km2, respectively. Our data suggest that warmer spring seasons (April–May) with higher precipitation rates lead to increased formation of supraglacial lakes. The time series decomposition shows a linear increase in the lake area of 11.12 ± 9.57% per year. Although the five-year observation period is too short to derive a significant trend, the tendency for a possible increase in the supraglacial lake area is in line with the pronounced positive anomalies of the SPI and STI during the observation period.
Travel Mode Recognition Using RBF Neural Network

This paper focuses on travel mode recognition based on Radial Basis Function (RBF) Neural Networks using the characters extracted from travel trace information collected by smartphone. First, the authors analyzed the characters of travel mode to find out what the key parameters are to divide the two kinds of travel mode by using the F-score method in order to make up the character vectors to recognize different travel modes. Eventually, a classifier of the RBF-based Neural Network can be established. This Neural Network is trained by travel mode samples extracted from travel trace data in Dalian. For comparison, BP Neural Networks are used. The result shows that the recognition accuracy rate of RBF Neural Network is better than BP Neural Network, and suggests that the RBF Neural Network has a better recognition performance.
Circular RNA, microRNA and Protein Profiles of the Longissimus Dorsi of Germany ZIKA and Sichuan White Rabbits

Due to the dietetic properties and remarkable nutritive value of rabbit meat, its industry is increasing rapidly. However, the association between circular RNAs, microRNAs, and proteins and muscle fiber type, and meat quality of rabbit is still unknown. Here, using deep sequencing and iTRAQ proteomics technologies we first identified 3159 circRNAs, 356 miRNAs, and 755 proteins in the longissimus dorsi tissues from Sichuan white (SCWrabs) and Germany great line ZIKA rabbits (ZIKArabs). Next, we identified 267 circRNAs, 3 miRNAs, and 29 proteins differentially expressed in the muscle tissues of SCWrabs and ZIKArabs. Interaction network analysis revealed some key regulation relationships between noncoding RNAs and proteins that might be associated with the muscle fiber type and meat quality of rabbit. Further, miRNA isoforms and gene variants identified in SCWrabs and ZIKArabs revealed some pathways and biological processes related to the muscle development. This is the first study of noncoding RNA and protein profiles for the two rabbit breeds. It provides a valuable resource for future studies in rabbits and will improve our understanding of the molecular regulation mechanisms in the muscle development of livestock. More importantly, the output of our study will benefit the researchers and producers in the rabbit breeding program.
Integrated Lymphopenia Analysis in Younger and Older Patients With Multiple Sclerosis Treated With Cladribine Tablets

Cladribine tablets (CladT) preferentially reduce B and T lymphocyte levels. As aging is associated with a decline in immune function, the effect of CladT on lymphocyte levels may differ by age. This post hoc analysis combined data from the Phase 3 CLARITY, CLARITY Extension, and ORACLE-MS studies to examine the effect of age (≤50 or >50 years) on lymphopenia following CladT 3.5 mg/kg (CladT3.5; cumulative dose over 2 years) treatment over 96 weeks. Both CladT3.5 and placebo were given over Weeks 1 and 5 (Year 1 treatment) and Weeks 48 and 52 (Year 2 treatment) from the start of the studies. Absolute lymphocyte count (ALC) and levels of lymphocyte subsets were examined in 1564 patients (Age ≤50 [placebo: N=566; CladT3.5: N=813]; Age >50 [placebo: N=75; CladT3.5: N=110]). In both age groups, following CladT3.5 treatment, nadir for ALC occurred at Week 9 (8 weeks following start of Year 1 treatment) and Week 55 (7 weeks following start of Year 2 treatment) of the 96-week period; for CD19+ B lymphocytes, nadir occurred at Week 9 (Year 1) and Week 52 (Year 2). For CD4+ T lymphocytes, nadir occurred at Week 16 (Year 1) in both age groups, and at Weeks 60 and 72 (Year 2) in the Age ≤50 and >50 groups, respectively. Nadir for CD8+ T lymphocytes occurred at Week 16 (Year 1) and Week 72 (Year 2) in the Age ≤50 group and levels remained in the normal range; nadir occurred at Week 9 (Year 1) and Week 96 (Year 2) in the Age >50 group. Lymphocyte recovery began soon after nadir following CladT3.5 treatment and median levels reached normal range by end of the treatment year in both age groups. By Week 96, ~25% of patients treated with CladT3.5 reported ≥1 episode of Grade ≥3 lymphopenia (Gr≥3L). The rate of certain infections was numerically higher in older versus younger patients who experienced Gr≥3L. In conclusion, CladT3.5 had a similar effect on ALC and lymphocyte subsets in both younger and older patient groups.
New Born Calf Serum Can Induce Spheroid Formation in Breast Cancer KAIMRC1 Cell Line

Three-dimensional (3D) cell culture systems have become very popular in the field of drug screening and discovery. There is an immense demand for highly efficient and easy methods to produce 3D spheroids in any cell format. We have developed a novel and easy method to produce spheroids from the newly isolated KAIMRC1 cell line in vitro. It can be used as a 3D model to study proliferation, differentiation, cell death, and drug response of cancer cells. Our procedure requires growth media supplemented with 10% new born calf serum (NBCS) and regular cell culture plates to generate KAIMRC1 spheroids without the need for any specialized 3D cell culture system. This procedure generates multiple spheroids within a 12–24-h culture. KAIMRC1 spheroids are compact, homogeneous in size and morphology with a mean size of 55.8 µm (±3.5). High content imaging (HCI) of KAIMRC1 spheroids treated with a panel of 240 compounds resulted in the identification of several highly specific compounds towards spheroids. Immunophenotyping of KAIMRC1 spheroids revealed phosphorylation of FAK, cJUN, and E-cadherin, which suggests the involvement of JNK/JUN pathway in the KAIMRC1 spheroids formation. Gene expression analysis showed upregulation of cell junction genes, GJB3, DSC1, CLDN5, CLDN8, and PLAU. Furthermore, co-culture of KAIMRC1 cells with primary cancer-associated-fibroblasts (CAFs) showcased the potential of these cells in drug discovery application.
Development of an In Vivo Probe to Track SARS-CoV-2 Infection in Rhesus Macaques

Infection with the novel coronavirus, SARS-CoV-2, results in pneumonia and other respiratory symptoms as well as pathologies at diverse anatomical sites. An outstanding question is whether these diverse pathologies are due to replication of the virus in these anatomical compartments and how and when the virus reaches those sites. To answer these outstanding questions and study the spatiotemporal dynamics of SARS-CoV-2 infection a method for tracking viral spread in vivo is needed. We developed a novel, fluorescently labeled, antibody-based in vivo probe system using the anti-spike monoclonal antibody CR3022 and demonstrated that it could successfully identify sites of SARS-CoV-2 infection in a rhesus macaque model of COVID-19. Our results showed that the fluorescent signal from our antibody-based probe could differentiate whole lungs of macaques infected for 9 days from those infected for 2 or 3 days. Additionally, the probe signal corroborated the frequency and density of infected cells in individual tissue blocks from infected macaques. These results provide proof of concept for the use of in vivo antibody-based probes to study SARS-CoV-2 infection dynamics in rhesus macaques.
A reconfigurable printed dipole antenna using RF PIN diodes

A frequency switchable printed dipole antenna is proposed for multiband application. The electrical length of the dipole can be changed by controlling the pin diodes states so that the antenna can operate in three different frequency bands. The larger/smaller of the current path, the smaller/larger of the resonance frequency can be obtained. Three resonant frequencies from 200 to 1400 MHz are selected in this bandwidth and proper matching is achieved for all resonant frequencies. Also, a pair of capacitive stubs at the end of dipole have been used for achieving a resonant frequency lower than a standard dipole of comparable length. For optimizing the antenna structure, a parametric analysis has been performed by calculating the length and width of radiators with formulas. All simulated results have been confirmed with measured data. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1151–1155, 2014
Relationship of Fat Mass Index and Fat Free Mass Index With Body Mass Index and Association With Function, Cognition and Sarcopenia in Pre-Frail Older Adults

Background Body mass index (BMI) is an inadequate marker of obesity, and cannot distinguish between fat mass, fat free mass and distribution of adipose tissue. The purpose of this study was twofold. First, to assess cross-sectional relationship of BMI with fat mass index (FMI), fat free mass index (FFMI) and ratio of fat mass to fat free mass (FM/FFM). Second, to study the association of FMI, FFMI and FM/FFM with physical function including sarcopenia, and cognition in pre-frail older adults. Methods Cross-sectional study of 191 pre-frail participants ≥ 65 years, 57.1% females. Data was collected on demographics, cognition [Montreal Cognitive Assessment (MoCA)], function, frailty, calf circumference, handgrip strength (HGS), short physical performance battery (SPPB) and gait speed. Body composition was measured using InBody S10. FMI, FFMI and FM/FFM were classified into tertiles (T1, T2, T3) with T1 classified as lowest and T3 highest tertile respectively and stratified by BMI. Results Higher FFMI and lower FM/FFM in the high BMI group were associated with better functional outcomes. Prevalence of low muscle mass was higher in the normal BMI group. FMI and FM/FFM were significantly higher in females and FFMI in males with significant gender differences except for FFMI in ≥ 80 years old. Small calf circumference was significantly less prevalent in the highest tertile of FMI, FM/FMI and FFMI. Prevalence of sarcopenic obesity and low physical function (HGS, gait speed and SPPB scores) were significantly higher in the highest FMI and FM/FFM tertile. Highest FFMI tertile group had higher physical function, higher MoCA scores, lower prevalence of sarcopenic obesity and sarcopenia, After adjustment, highest tertile of FFMI was associated with lower odds of sarcopenia especially in the high BMI group. Highest tertile of FM/FFM was associated with higher odds of sarcopenia. Higher BMI was associated with lower odds of sarcopenia. Conclusion FFMI and FM/FFM may be a better predictor of functional outcomes in pre-frail older adults than BMI. Cut-off values for healthy BMI values and role of calf circumference as a screening tool for sarcopenia need to be validated in larger population. Health promotion intervention should focus on FFMI increment.
Circulating Placental Alkaline Phosphatase Expressing Exosomes in Maternal Blood Showed Temporal Regulation of Placental Genes

Background: Analysis of placental genes could unravel maternal-fetal complications. However, inaccessibility to placental tissue during early pregnancy has limited this effort. We tested if exosomes (Exo) released by human placenta in the maternal circulation harbor crucial placental genes. Methods: Placental alkaline phosphate positive exosomes (ExoPLAP) were enriched from maternal blood collected at the following gestational weeks; 6–8th (T1), 12–14th (T2), 20–24th (T3), and 28th−32nd (T4). Nanotracking analysis, electron microscopy, dynamic light scattering, and immunoblotting were used for characterization. We used microarray for transcriptome and quantitative PCR (qPCR) for gene analysis in ExoPLAP. Results: Physical characterization and presence of CD63 and CD9 proteins confirmed the successful ExoPLAP enrichment. Four of the selected 36 placental genes did not amplify in ExoPLAP, while 32 showed regulations (n = 3–8/time point). Most genes in ExoPLAP showed significantly lower expression at T2–T4, relative to T1 (p < 0.05), such as NOS3, TNFSF10, OR5H6, APOL3, and NEDD4L. In contrast, genes, such as ATF6, NEDD1, and IGF2, had significantly higher expression at T2–T4 relative to T1. Unbiased gene profiling by microarray also confirmed expression of above genes in ExoPLAP-transcriptome. In addition, repeated measure ANOVA showed a significant change in the ExoPLAP transcriptome from T2 to T4 (n = 5/time point). Conclusion: Placental alkaline phosphate positive exosomes transcriptome changed with gestational age advancement in healthy women. The transcriptome expressed crucial placental genes involved in early embryonic development, such as actin cytoskeleton organization, appropriate cell positioning, DNA replication, and B-cell regulation for protecting mammalian fetuses from rejection. Thus, ExoPLAP in maternal blood could be a promising source to study the placental genes regulation for non-invasive monitoring of placental health.
The Changing Trend in Clinical Characteristics and Outcomes of Male Patients With Urethral Stricture Over the Past 10 Years in China

Background: Male urethral stricture is a disease with a high incidence rate. With social-economic development in the developing countries, the trend of etiology and treatment of male urethral stricture changed was speculated. Methods: The clinical data of the male patients with urethral stricture from 2000 to 2019 were analyzed. The subjects were divided into Group A (2000–2009) and Group B (2010–2019) according to treatment time. The pooled analysis of the data extracted from pieces of literature was also performed. Results: About 540 patients were included in the present study, including 235 patients in Group A and 305 patients in Group B. In recent 10 years, trauma has still been the main cause of urethral stricture. Iatrogenic injury, especially transurethral operation, increases significantly, while male urethral stricture secondary to radiotherapy and infection decrease. Urethroplasty increases and the reoperation rate decreases in treating simple urethral stricture, and flap urethroplasty also increases in treating complex urethral stricture. The results of a pooled analysis of data from 11 centers in Mainland China are partially consistent with it. Complications, such as urethral fistula, false canal, ejaculation disorder, and penile curvature, decrease significantly. Conclusions: The main causes of urethral stricture in the recent 10 years are still trauma and iatrogenic injuries, and the etiology of urethral stricture is related to socioeconomic development. With the increase of intracavitary minimally invasive treatment and flap urethroplasty, the curative effect is increasing, while iatrogenic urethral stricture cannot be ignored.
Production of Succinic Acid From Basfia succiniciproducens

Basfia succiniciproducens is a facultative anaerobic capnophilic bacterium, isolated from rumen, that naturally produces high amounts of succinic acid by fixing CO2 and using fumarate as final electron acceptor. This metabolic feature makes it one of the ideal candidates for developing biotechnological industrial routes that could eventually replace the polluting and environment unfriendly petrochemical ones that are still main sources for the production of this value-added compound. In fact, due to the large number of applications of succinic acid that range from the more traditional ones as food additive or pharmaceutical intermediate to the most recent as building block for biopolymers and bioplastic, increasing demand and market size growth are expected in the next years. In line with a “green revolution” needed to preserve our environment, the great challenge is the establishment of commercially viable production processes that exploit renewable materials and in particular preferably non-food lignocellulosic biomasses and waste products. In this review, we describe the currently available literature concerning B. succiniciproducens since the strain was first isolated, focusing on the different renewable materials and fermentation strategies used to improve succinic acid production titers to date. Moreover, an insight into the metabolic engineering approaches and the key physiological characteristics of B. succiniciproducens deduced from the different studies are presented.
Apoptosis, Autophagy, NETosis, Necroptosis, and Pyroptosis Mediated Programmed Cell Death as Targets for Innovative Therapy in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that can lead to clinical manifestations of systemic diseases. Its leading features include chronic synovial inflammation and degeneration of the bones and joints. In the past decades, multiple susceptibilities for rheumatoid arthritis have been identified along with the development of a remarkable variety of drugs for its treatment; which include analgesics, glucocorticoids, nonsteroidal anti-inflammatory medications (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs), and biologic response modifiers (bDMARDs). Despite the existence of many clinical treatment options, the prognosis of some patients remains poor due to complex mechanism of the disease. Programmed cell death (PCD) has been extensively studied and ascertained to be one of the essential pathological mechanisms of RA. Its dysregulation in various associated cell types contributes to the development of RA. In this review, we summarize the role of apoptosis, cell death-associated neutrophil extracellular trap formation, necroptosis, pyroptosis, and autophagy in the pathophysiology of RA to provide a theoretical reference and insightful direction to the discovery and development of novel therapeutic targets for RA.
ENGINEER YOUR SUPPLY CHAIN TO COPE WITH DEMAND UNCERTAINTIES

As part of an investigation into the range of demand uncertainty encountered in practice, the results of a crosssector survey of 59 value streams are presented. The survey highlights the requirement for a spectrum of supply chain strategies linking the two extremes of lean and agile. An electronic product case study concludes the article and illustrates how an organisation can address a mismatch between supply chain strategy and product demand characteristics. In this instance the strategy was not agile enough, hence the case study explains how the supply chain was engineered to cope with demand uncertainties.