Miracle-dz/UniFAR-FTUs huggingface dataset:
Childhood Absence Epilepsy Associated With Concomitant Centrotemporal Spikes

Objectives The coexistence of generalized epileptiform discharges of 3Hz spike-and-wave complexes, which are the hallmark of childhood absence epilepsy (CAE), and centrotemporal spikes, which are characteristic of benign epilepsy with centrotemporal spikes (BECTs) in the same or subsequent EEGs appears to be very rare. Only a few published reports have shown a possible concomitance of CAE and BECTs electrographic changes. The study aimed to analyze electrographic and clinical features of patients with CAE who had concomitant or subsequent EEG features of BECTs. Method During a five-year analysis period (2014-2018), 277 children with BECTs and 93 children with CAE were diagnosed and treated at the pediatric neurology unit of Sultan Qaboos University Hospital (SQUH) in Muscat, Oman. Nine patients were identified to have overlapping EEG findings of both epileptic syndromes. We then analyzed the nine children's clinical features, outcomes, and EEG findings in detail. Results The clinical onset of all our patients aged 5-14 years (six boys, three girls) was characterized by the absence of seizures, either typical (seven children) or atypical (two children). Six out of nine patients presented with concomitant electrographic features of both syndromes, whereas three patients experienced the EEG pattern of two syndromes at different times. All nine children were treated with valproate as the first-line medication, with reasonable seizure control. However, three patients required a second add-on medication. Despite good seizure control, six of our patients had poor school performance and five children had comorbid conditions such as ADHD and learning disability. Conclusion The coexistence of CAE and BECTS is described in the literature albeit rare. This overlap is mostly in electrographic features with or without the clinical features seen in both syndromes.
The Relationship Between In-Hospital Mortality and Frontal QRS-T Angle in Patients With COVID-19

Background Recent studies have demonstrated that the frontal QRS-T angle, defined as the angle between the mean QRS and T vectors, is a strong independent predictor of mortality in patients with cardiovascular disease and in the normal population. In this study, we aimed to investigate the relationship between frontal QRS-T angle and in-hospital mortality in COVID-19 patients. Methods A total of consecutive 532 patients with positive polymerase chain reaction (PCR) tests were enrolled. The patients were divided into two groups as in-hospital mortality and survival groups. Frontal QRS-T angle was automatically calculated from the admission electrocardiography (ECG). Results The median age in the study population was 62 (49-72) years and 273 (51.4%) of the patients were male. The median frontal QRS-T angle was 40 degrees (20-67 IQR) in the in-hospital mortality group, while it was 27 (11-48 IQR) in the survival group (p=0.001). In multivariable logistic regression analysis, frontal QRS-T angle was found to be an independent predictor of mortality (Odds ratio (OR):1.01, 95% Confidence interval (CI):1.00-1.02, p=0.036). Conclusion Frontal QRS-T angle, which was observed wider in the in-hospital mortality group, was found to be associated with in-hospital mortality in patients hospitalized for COVID-19.
Why Stromae Matters: Dance Music as a Master Class for the Social Issues of Our Time

Abstract:This article presents an analysis of Stromae’s rise to fame, of his thematic choices and artistry, and of his approach to social commentary. As one of only three French-speaking artists to sing at Madison Square Garden, Stromae offers more than popular dance music. The serious issues raised in his songs highlight his multi-layered social critique and challenge common assumptions about what constitutes popular music. His musical productions, labeled as “attent-art” and “la danse des maux,” reinforce a complex dialectical enterprise that equally benefits from and subverts the use of social media in this new era of music making.
Costing and cost-effectiveness of Cepheid Xpert HIV -1 Qual Assay using whole blood protocol versus PCR by Abbott Systems in Malawi.

Background Timely diagnosis of HIV in infants and children is an urgent priority. In Malawi, 40,000 infants annually are HIV exposed. However, gold standard polymerase-chain-reaction (PCR) based testing requires centralised laboratories, causing turn-around times (TAT) of 2 to 3 months and significant loss to follow-up. If feasible and acceptable, minimising diagnostic delays through HIV Point-of-care-testing (POCT) may be cost-effective. We assessed whether POCT Cepheid Xpert HIV-1 Qual assay whole blood (XpertHIV) was more cost-effective than PCR. Methods From July-August 2018, 700 PCR Abbott tests using dried blood spots (DBS) were performed on 680 participants who enrolled on the feasibility, acceptability and performance of the XpertHIV study. Newly identified HIV-positive We conducted a cost-minimisation and cost-effectiveness analysis of XpertHIV against PCR, as the standard of care. A random sample of 200 caregivers from the 680 participants had semi-structured interviews to explore costs from a societal perspective of XpertHIV at Mulanje District Hospital, Malawi. Analysis used TAT as the primary outcome measure. Results were extrapolated from the study period (29 days) to a year (240 working days). Sensitivity analyses characterised individual and joint parameter uncertainty and estimated patient cost per test. Results During the study period, XpertHIV was cost-minimising at $42.34 per test compared to $66.66 for PCR. Over a year, XpertHIV remained cost-minimising at $16.12 compared to PCR at $27.06. From the patient perspective (travel, food, lost productivity), the cost per test of XpertHIV was $2.45. XpertHIV had a mean TAT of 7.10 hours compared to 153.15 hours for PCR. Extrapolates accounting for equipment costs, lab consumables and losses to follow up estimated annual savings of $2,193,538.88 if XpertHIV is used nationally, as opposed to PCR. Conclusions This preliminary evidence suggests that adopting POCT XpertHIV will save time, allowing HIV-exposed infants to receive prompt care and may improve outcomes. The Malawi government will pay less due to XpertHIV's cost savings and associated benefits.
Survival Outcomes of Breast-Conserving Therapy versus Mastectomy in Early-Stage Breast Cancer, Including Centrally Located Breast Cancer: A SEER-Based Study

Purpose This study aims to analyze the survival outcomes of breast cancer (BC) patients, especially centrally located breast cancer (CLBC) patients undergoing breast-conserving therapy (BCT) or mastectomy. Methods Surveillance, epidemiology, and end results (SEER) data of patients with T1-T2 invasive ductal or lobular breast cancer receiving BCT or mastectomy were reviewed. We used X-tile software to convert continuous variables to categorical variables. Chi-square tests were utilized to compare baseline information. The multivariate logistic regression model was performed to evaluate the relationship between predictive variables and treatment choice. Survival outcomes were visualized by Kaplan–Meier curves and cumulative incidence function curves and compared using multivariate analyses, including the Cox proportional hazards model and competing risks model. Propensity score matching was performed to alleviate the effects of baseline differences on survival outcomes. Result A total of 180,495 patients were enrolled in this study. The breast preservation rates fluctuated around 60% from 2000 to 2015. Clinical features including invasive ductal carcinoma (IDC), lower histologic grade, smaller tumor size, fewer lymph node metastases, positive ER and PR status, and chemotherapy use were independently correlated with BCT in both BC and CLBC cohorts. In all the classic Cox models and competing risks models, BCT was an independent favorable prognostic factor for BC, including CLBC patients in most subgroups. In addition, despite the low breast-conserving rate compared with tumors located in the other areas, CLBC did not impair the prognosis of BCT patients. Conclusion BCT is optional and preferable for most early-stage BC, including CLBC patients.
Sustainable multi-objective optimization of a machining parameter model for multi-pass turning processes

Abstract In this study, we developed an optimization model for determining the optimal parameters for multi-pass CNC turning processes. The six elements of sustainable manufacturing were considered in this study to derive new insights into multi-pass turning modeling. This paper details the relationship between time and power and considers total noise in terms of the personal health element and cost of quality in terms of the manufacturing cost element. The objective functions for our model include the total energy, surface roughness, total noise, total cost, and total carbon emission. The decision variables for our model include the cutting depth, feed rate, cutting speed, and number of roughing passes. The proposed model was solved using the Gamultiobj algorithm (MATLAB). This algorithm was used to identify a set of non-dominated points on the Pareto front. Additionally, a single optimal solution is identified using the TOPSIS method. There are twelve combinations of multi-objective optimization processes carried out. One of twelve combinations, for the five objective functions, the optimal values were determined as follows: total energy value of 495,965.751 joules, surface roughness of 0.285 μm, average noise of 78.788 dBA, total cost of $288.587, and carbon emission of 337,748.265 kgCO2.
Uses of Antibiotics Alone in Case of Uncomplicated Appendicitis

The frequent abdominal surgical emergency is acute appendicitis with a significantly less lifelong risk. One of the most common surgeries manifested is an appendectomy, but with recent advances, non-operative management has evolved using antibiotics. In adult patients with simple appendicitis, we identified the role of surgical and non-surgical therapy. One of the most common surgeries manifested is an appendectomy, but with recent advances, non-operative management has evolved using antibiotics. In adults suffering from mild appendicitis, we identified the role of surgical and non-surgical therapy. The analysis indicated that the Antibiotics versus Primary Appendectomy in Children (APAC) did not establish non-inferiority of antibiotics vs. appendectomy with a pre-specified small margin. In contrast to the majority of appendectomies that are carried out laparoscopically, the surgeries were almost usually open. Appendectomies, both laparoscopic and open, are not the same procedure. Antibiotic therapy is effective in about 60% of cases of simple appendicitis. A surgery-only strategy would reduce antibiotic exposure, a factor to consider in these days of antimicrobial stewardship. Therefore, studies are being conducted on whether to shift alone on antibiotics or with appendectomy to have better results with fewer complications. Future studies should focus on appendicitis features and long-term unfavorable consequences, including antibiotic resistance or Clostridium difficile colitis, most responsive to antibiotics by utilizing laparoscopic procedures as controls. Using it along with appendectomy may change the outcome showing a better prognosis.
Zebrafish brain and skull imaging based on polarization‐sensitive optical coherence tomography

Zebrafish brain imaging is very important for the study of brain disease and regeneration. We scanned the adult zebrafish brain before and after skull removal and monitored the recovery process of a head wound by polarization‐sensitive optical coherence tomography (PS‐OCT) in this paper. We analyzed the structure and polarization characteristics of the brain and skull in PS‐OCT images, and found their internal microstructure can be clearly identified with the polarization information. Further, we estimated the pigment distribution of the skull area and found that the density of pigment in skull is a critical factor of affecting zebrafish brain in vivo polarization imaging. Our results demonstrated that more features of brain can be displayed by introducing the polarization information, and proved high‐resolution PS‐OCT will play a great potential role in studying the zebrafish brain and skull.
An Approach for Building Security Resilience in AUTOSAR Based Safety Critical Systems

AUTOSAR, a worldwide development partnership among automotive parties to establish an open and standardized software architecture for electronic control units (ECUs), has seen great success in recent years by being widely adopted in deeply embedded automotive ECUs. Increasing the security resilience of AUTOSAR based systems is a crucial step in securing safety critical automotive systems. We study AUTOSAR safety mechanisms and demonstrate how they can be used as attack vectors to degrade the vehicle safety. We show the need to harmonize the fail-safe response with the secure state of the system. And we evaluate the overlap in the properties of safety mechanisms with security objectives to highlight methods for hardening automotive systems security.
Impact of Diabetic Nephropathy on Pulmonary Function and Clinical Outcomes

Objective The main objective is to study the effect of diabetic nephropathy on pulmonary function and clinical outcomes. Methods The method is to retrospectively analyze patients with diabetic nephropathy (DN) in our hospital from April 2018 to March 2022 as study subjects. The differences in baseline data, serum indicators, renal function indicators, and pulmonary function of patients at different clinical stages were analyzed and then explored. Finally, logistic regression was used to analyze the risk factors affecting patients' clinical outcomes and to evaluate the diagnostic effects. Results Baseline information (age, disease duration, BMI, and systolic and diastolic blood pressure), serum indicators (HbA1c, FBG, 2hPG, TG, TC, and LDLC), renal function indicators (CysC, BUN, and Scr), and pulmonary function (TLC, VC, FEV1, FEV1/FVC, MVV, MEF25, MEF50 MEF75, DLCO, and DLCO/VA) were significantly different (P < 0.01); multiple logistic regression analysis showed that SBP, HbA1c, FBG, 2hPG, BUN, Scr, TLC, VC, FEV1/FVC, MVV, DLCO, and DLCO/VA were all key factors in the development of clinical outcomes in DN (P < 0.05). ROC analysis showed that all of these important factors had an AUC greater than 0.75 for the diagnosis of DN with high sensitivity and specificity. Conclusion Serum and renal function indices of DN patients gradually increased with stage, accompanied by a decrease in pulmonary ventilation, and diffusion function; SBP, HbA1c, FBG, 2hPG, BUN, Scr, TLC, VC, FEV1/FVC, MVV, DLCO, and DLCO/VA were all key factors affecting the clinical outcome of DN; controlling blood glucose, lipids, improving pulmonary ventilation, and diffusion function can better prevent the occurrence and worsening of DN.
Comparison of heavy charged particles and x-rays for axial tomograpic scanning

Heavy charged particles are applicable to the problem of 3- dimensional reconstruction of electron density distributions of biological samples. The transverse uncertainty in the path of a heavy charged particle due to multiple scattering can be reduced by measuring the entrance and exit positions and angles of the particle. Patient doses for He ions and 80 keV x rays are compared under conditions suitable for imaging the human head. (auth)
Atmospheric Neutron Soft Errors in 3-D NAND Flash Memories

The sensitivity of vertical-channel 3-D NAND flash memories to wide-energy spectrum neutrons was investigated. The effects of neutron exposure on a 3-D floating gate (FG) cells were studied in terms of threshold voltage shifts and raw bit error rates. The neutron failure rates obtained in the accelerated tests were extrapolated to field conditions at sea level and aircraft altitudes. The results are compared with previous data on 3-D nand flash devices irradiated with heavy ions, as well as data on planar FG cell technologies.
Evaluation of poisoning cases that admitted to the emergency department for suicidal ideation

Aim: In this study, we aimed to evaluate the effects of gender, age, time of admission to the emergency department, season, drug used, the time patients were admitted to the emergency department following the drugs administration, and psychiatric illness history on the clinical outcome of patients by examining the patients who admitted to our emergency department after taking suicidal drugs. Materials and Methods: The data of the study were obtained as a result of the retrospective examination of the cases who took drugs for suicidal purposes, who admitted to the emergency department of our hospital between January 2019-January 2020. We divided those who were discharged and admitted to the ward as good clinical outcome, and those who were admitted to the intensive care unit and those who died had poor clinical outcome. We statistically analyzed the effects of age, gender, the active substance used, the time of admission to the emergency department, the number of hours after which it was presented, a previous suicide attempt, and a history of psychiatric illness on clinical outcomes. Results: 295 patients were included in the study. 64.4%(190) of the cases were female and 35.6%(105) were male. The mean age of the patients is 32.9, and the majority of them are in the 25-34 age group (31.5%). The fact that the patients were male, admitted to the emergency room 4 hours after taking the drug, admitted to the emergency room between 00.00-07.59, committed suicide with psychiatric medication, had a previous suicide attempt and diagnosis of psychiatric illness, had a statistically poor clinical outcome(p<0.001). Conclusion: As a result, the history of the patients, the active substances they took, the hours and duration of their arrival to the emergency department can be used to predict the occurrence of serious clinical pictures in suicidal drug intake.
H2O masers in nearby irregular galaxies

The results of a search for luminous interstellar H 2 O masers in 15 nearby irregular galaxies are presented. One new maser was detected in the Magellanic-type irregular galaxy IC 10. It was observed six times between 1987 and 1990 and did not exhibit flux density variations exceeding a factor of three. The newly discovered maser is located 2'to the north of another, more luminous H 2 O maser source, which has been monitored over a time interval of six years. The position of the υ LSR = − 332 km s −1 component of the more luminous maser was determined to an accuracy of ∼ 2″. This component was undergoing a «slow» burst during 1985 and most of 1986, with the linewidth varying as the -1/3 power of the flux density
A novel modification to TW-GIA for controlling heat input of base metal

ABSTRACT Bypass coupling triple-wire gas indirect arc welding (TW-GIA) has been proposed to control the heat input of base metal and consequently improve the weld forming as per the requirement. The influence of the bypass current on arc behavior, welding stability, and weld forming have been investigated. Results showed that the wetting angle and reinforcement reduced gradually, and the weld bead penetration increased with the bypass current increase. The reason was that the workpiece heating mode was changed due to the bypass circuit coupling. It was observed that the heat source was composed of two indirect arcs and two direct arcs, and they were in a coupling state. When the bypass current was 280 A, the electrical parameters of arc fluctuations were at a maximum, and the coupled arc state was not conducive to obtain a stable welding process. Compared to the lack of sidewall fusion and incomplete joint penetration defects of the weld with TW-GIA, the good butt joint of 12 mm thickness steel plates was successfully obtained with bypass coupling TW-GIA under the same energy consumption.
Non-Fermi-liquid behavior in CeIr In5 near a metamagnetic transition

We present a specific heat and resistivity study of $\mathrm{Ce}\mathrm{Ir}{\mathrm{In}}_{5}$ in magnetic fields up to $17\phantom{\rule{0.3em}{0ex}}\mathrm{T}$ and temperature down to $50\phantom{\rule{0.3em}{0ex}}\mathrm{mK}$. Both quantities were measured with the magnetic field parallel to the $c$ axis $(H\ensuremath{\Vert}[001])$ and within the $a\text{\ensuremath{-}}b$ plane $(H\ensuremath{\perp}[001])$. Non-Fermi-liquid (NFL) behavior develops above $12\phantom{\rule{0.3em}{0ex}}\mathrm{T}$ for $H\ensuremath{\Vert}[001]$. The Fermi-liquid state is much more robust for $H\ensuremath{\Vert}[001]$ and is suppressed only moderately at the highest applied field. Based on the observed trends and the proximity to a metamagnetic phase transition, which exists at fields above $25\phantom{\rule{0.3em}{0ex}}\mathrm{T}$ for $H\ensuremath{\Vert}[001]$, we suggest that the observed NFL behavior in $\mathrm{Ce}\mathrm{Ir}{\mathrm{In}}_{5}$ is a consequence of a metamagnetic quantum critical point.
Risk Factors for Esophageal Squamous Cell Carcinoma in Patients with Head and Neck Squamous Cell Carcinoma

Background Esophageal squamous cell carcinoma (ESCC) is a common second primary neoplasia in patients with a history of head and neck squamous cell carcinoma (HNSCC). The aim of this study was to provide further information and novel insights into the risk factors for ESCC in patients with HNSCC. Methods We retrospectively analyzed 98 HNSCC patients diagnosed from 2007 to 2017, 30 HNSCC patients suffering from ESCC, who had undergone endoscopic examination because of positive imaging examinations or symptoms, and 68 HNSCC patients who had no ESCC occurrence for at least six years post-HNSCC diagnosis. Associated clinicopathological data and lifestyle information of the ESCC group and the without ESCC group were collected, and a case-control study of risk factors was analyzed between the two groups. Results The majority (83.4%) of the cases with HNSCC esophageal cancers were male patients over 50 years. We established that 93.75% (30/32) of the ESCC occurred within six years after HNSCC diagnosis. HNSCC location, stage, and radiotherapy history had no significant association with the development of ESCC. High Ki67 labeling index (Ki67 LI) (>46) patients tended to be 3.1 times (95% CI = 1.3–7.6) more likely to develop ESCC compared to low Ki67 LI (≤45) patients (P < 0.05). Drinkers with alcohol flushing response were at a 3.3 times higher risk to have ESCC (95% CI = 1.0–10.4) than drinkers without flush response (P < 0.05). Conclusions HNSCC patients, especially drinkers with an alcohol flushing response, as well as those with high Ki67 LI of HNSCC tissue, were more likely to develop ESCC.
Design of Dual-band Microstrip Antenna with U-shaped slot

In some applications it is required to have dual band characteristics instead of single band. This characteristic can be obtained by embedding a U-slot in the patch and hence the radiating patch includes a pair of step-slots. In this paper, we propose a dual-band microstrip patch antenna with u-shaped slot fed by coaxial feeding technique. The proposed antenna is designed, simulated and optimized using Ansoft HFSS Vs 13. The simulation results are presented in terms of return loss, VSWR, input impedance, Gain and radiation pattern. The dimensions are optimized to achieve the exact operating frequencies using resonating frequency control mechanism. The results showed that the U-shaped slot microstrip antenna is efficiently operated at 2.4 GHZ and 4.6 GHZ resonant frequencies for WLAN applications. Keywords—Microstrip, patch antenna, WLAN, Ansoft HFSS
Everything you wanted to know about RCAT but were afraid to ask

A transistor switching circuit is provided for providing an indication of when the level of an input signal has passed through a first threshold level, such indication continuing unless such input signal has returned beyond the first threshold level to a second threshold level. Such circuit is useful in indicating whether the battery of a battery powered device should be replaced taking into consideration small variations in the output of the battery after the initial replacement indication has been provided.