Miracle-dz/UniFAR-FTUs huggingface dataset:
Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation

PURPOSE Clonal hematopoiesis (CH) can be transmitted from a donor to a recipient during allogeneic hematopoietic cell transplantation. Exclusion of candidate donors with CH is controversial since its impact on recipient outcomes and graft alloimmune function is uncertain. PATIENTS AND METHODS We performed targeted error-corrected sequencing on samples from 1,727 donors age 40 years or older and assessed the effect of donor CH on recipient clinical outcomes. We measured long-term engraftment of 102 donor clones and cytokine levels in 256 recipients at 3 and 12 months after transplant. RESULTS CH was present in 22.5% of donors, with DNMT3A (14.6%) and TET2 (5.2%) mutations being most common; 85% of donor clones showed long-term engraftment in recipients after transplantation, including clones with a variant allele fraction < 0.01. DNMT3A-CH with a variant allele fraction ≥ 0.01, but not smaller clones, was associated with improved recipient overall (hazard ratio [HR], 0.79; P = .042) and progression-free survival (HR, 0.72; P = .003) after adjustment for significant clinical variables. In patients who received calcineurin-based graft-versus-host disease prophylaxis, donor DNMT3A-CH was associated with reduced relapse (subdistribution HR, 0.59; P = .014), increased chronic graft-versus-host disease (subdistribution HR, 1.36; P = .042), and higher interleukin-12p70 levels in recipients. No recipient of sole DNMT3A or TET2-CH developed donor cell leukemia (DCL). In seven of eight cases, DCL evolved from donor CH with rare TP53 or splicing factor mutations or from donors carrying germline DDX41 mutations. CONCLUSION Donor CH is closely associated with clinical outcomes in transplant recipients, with differential impact on graft alloimmune function and potential for leukemic transformation related to mutated gene and somatic clonal abundance. Donor DNMT3A-CH is associated with improved recipient survival because of reduced relapse risk and with an augmented network of inflammatory cytokines in recipients. Risk of DCL in allogeneic hematopoietic cell transplantation is driven by somatic myelodysplastic syndrome–associated mutations or germline predisposition in donors. DNMT3A clonal hematopoiesis in donors associated with better survival in hematopoietic cell transplant recipients
Uses of Elaeis guineensis oil for Stress Management during the Transportation of Catfish Fingerlings: A Dose-Dependent Outcome

Cameroonian farmers used Elaeis guineensis oil (EGO) named usually palm oil to reduce stress and mortality during the transportation of catfish fingerlings. The present study is aimed to evaluate the uses of EGO for stress management during the transportation of catfish fingerlings. Antioxidant activities of EGO were assessed in vitro. 1500 fingerlings were transported from Douala (Littoral Region, Cameroon) to Yaoundé (Centre Region Cameroon). The transportation was for 7 h 55 min in black tins of 10 L which contain 8 L of water and 100 fingerlings each. The following treatment was administrated: commercial anti-stress, 2, 4, and 6 drops of EGO. Control received no treatment and all groups were triplicated. After 10 fingerlings were sacrificed by decapitation. Total protein, total bilirubin (TB), triglycerides level, and lactate deshydrogenase (LDH) activity were assessed in the liver as well as oxidant stress parameters. Brain and gills were fixed for histopathological analysis. Results showed that transportation of catfish fingerlings induced a significant increase of TB level and LDH activity in the liver. Indeed, it induced cerebellar and gills necrosis. Moreover, EGO exhibits antioxidant activities in vitro against DPPH, ABTS radicals, and possesses a ferric reducing antioxidant power of 6.31 mEAG/g. This observation was confirmed in vivo by the increase in a dose-dependent manner of GSH and nitrites levels in the liver compared to control. However, the administration of 6 drops of EGO increased significantly (p < 0.05) the activity of LDH in the liver compared to control. Thus, high dose induced anaerobic respiration which was confirmed by alveolar necrosis in gills and neurodegeneration although low dose of EGO (2-4 drops) prevented those alterations compared to control. Hence, low doses of Elaeis guineensis oil can prevent liver, cerebellar and gills impairment during artisanal transportation to reduce the effects of stress.
A Review: Testing Antioxidant Activity on Kawista Plants (Limonia acidissima L.) in Indonesia

BACKGROUND: Antioxidants are natural ingredients that can block the oxidation process of free radicals that enter the body so that damage to body cells can be prevented. Kawista plants are one of the plants that have antioxidant activity. AIM: This article review aims to determine the compounds that have antioxidant activity found in Kawista plants, the method used in testing antioxidants on Kawista plants, and the IC50 value found in antioxidant testing on Kawista plants. METHODS: The method used in this study is the Population, Intervention, Control, and Outcome method through inclusion and exclusion criteria using the keywords “Antioxidant activity of Limonia acidissima,” “Antioxidant activity of Feronia limonia,” “Antioxidant activity of Kawista,” “Testing Antioxidants in L. acidissima,” and “L. acidissima” with databases used for literature searches. RESULTS: This review shows that Kawista plants have antioxidant activity of various compounds based on the test method used. CONCLUSION: Compounds in Kawista plants that have antioxidant activity are phenols, especially phenolic acids, flavonoids, flavonols, triterpenoids, saponins, tannins, terpenes, steroids, alkaloids, and glycosides. Kawista plant activity tested had IC50 with an average value of very strong (16.45 g/mL), strong (77.85 g/mL), moderate (135.02 g/mL), weak (196.67 g/mL), and very weak (751.89 g/mL).
An edge-based smoothed finite element for buckling analysis of functionally graded material variable-thickness plates

The paper aims to extend the ES-MITC3 element, which is an integration of the edge-based smoothed finite element method (ES-FEM) with the mixed interpolation of tensorial components technique for the three-node triangular element (MITC3 element), for the buckling analysis of the FGM variable-thickness plates subjected to mechanical loads. The proposed ES-MITC3 element is performed to eliminate the shear locking phenomenon and to enhance the accuracy of the existing MITC3 element. In the ES-MITC3 element, the stiffness matrices are obtained by using the strain smoothing technique over the smoothing domains formed by two adjacent MITC3 triangular elements sharing the same edge. The numerical results demonstrated that the proposed method is reliable and more accurate than some other published solutions in the literature. The influences of some geometric parameters, material properties on the stability of FGM variable-thickness plates are examined in detail.
Patient delay impact on breast cancer survival at Khartoum Referral Hospital: a retrospective study

Background: Breast cancer can be invasive and advanced at diagnosis causing enormous suffering and premature death. Delay to stage diagnosis and treatment is related to survival evaluation and several factors determine delay. The aim of the study was to examine predictor covariates associated with breast cancer delay and its impact on patient prognosis and survival. Methods: This retrospective cross-sectional hospital-based study was carried out at Khartoum Oncology Hospital. Participants were 411 breast cancer patients diagnosed and treated during the period 2016. Patients’ pathological and socio-demographic data were extracted from their medical files and delay data from telephone questionnaire survey and survival times calculated from follow-up. Fisher exact test, Cox and Logistic regression models were used to examine relationships between demographic, clinical and delay variables and survival outcome. Results: The mean age of the study subjects was 50.07 years old and the majority were ≥45 years. Cancer delay analysis showed that there were different reasons for different types of delay but the majority of participants (86.2%) claimed fear of the disease and treatment and lack of information were real drivers of delay. The study confirmed the majority of participants expressed long delay estimated at 28.3 weeks and patient delay had a significant association with the advanced stage (P-value<0.05). The hazard ratio was four times for risk of dying from cancer for long delay compared to the short one. Conclusion: The results of the study suggest delays at diagnosis and treatment are more common steps leading to advanced stage at diagnosis and poor survival. Early detection of the disease provides tremendous opportunities for early diagnosis, effective treatment and high chances of survival.
EFFECT OF REPLACEMENT OF FISHMEAL BY AZOLLA LEAF MAEL ON GROWTH, FOOD UTILIZATION, PANCREATIC PROTEASE ACTIVITY AND RNA/DNA RATIO IN THE FINGERLINGS OF LABEO

Dried water fern (Azolla pinnata) leaf meal was substituted for fish meal in practical diets of Labeo rohita fingerlings. Five isonitrogenous diets (38% crude protein) were formulated in which fish meal (68.9% crude protein) was replaced at varying levels (D1 = Control, 0% replacement; D2 = 25%; D3 = 50%; D4 = 75% and D5 = 100%) with protein from Azolla meal (25.81% crude protein). Carp fed a control diet had significantly (p < 0.05) better growth response and nutrient utilization. Growth depression of fish increased with increasing dietary levels of Azolla meal. Diet D5 containing 100% replacement of Azolla meal gave the poorest feed conversion ratio as it contain higher amount of trypsin inhibitor. There was marked reduction in cost the diets incorporated with Azolla meal. With the gradual inclusion of Azolla meal in the diets, the pancreatic enzyme activity was increased significantly up to 50% replacement and then decreasing trend was noticed during 60 days feeding trial. Growth rate of Labeo rohita and RNA/DNA ratio were reduced by insufficiently heated meals but properly heated Azolla meal improve nutritional quality as well as improvement of growth rate. Dry processing methods other than sun drying are suggested for the improvement of nutritional quality of Azolla leaf meal in carp diets. It was concluded that the antinutritional or limiting factor present in Azolla leaf meal are antitryptic and reduces the growth rate, if do not take proper care for the nutritional security.
Computational complexity certiﬁcation for embedded MPC based on dual gradient method

In this paper we analyze the computational complexity of a linear model predictive control (MPC) scheme for embedded systems based on the dual gradient algorithm. We recast our MPC problem as a linearly constrained convex problem. When it is di ﬃ cult to project on the primal feasible set described by linear constraints, we use the Lagrangian relaxation to handle the complicated constraints and then, we apply the dual gradient algorithm for solving the corresponding dual. We give a uniﬁed convergence analysis for the dual gradient algorithm: we provide sublinear or linear estimates on the primal suboptimality and feasibility violation of the generated approximate primal solutions. Our analysis relies on the Lipschitz property of the dual function or an error bound property. Furthermore, the iteration complexity analysis is based on two types of approximate primal solutions: an average primal sequence or the last primal iterate sequence. We also discuss implementation aspects of the proposed algorithm on constrained linear MPC for embedded systems.
FCPA and Market Quality in Emerging Economies

In this paper we tried to explore the overall effects of FCPA in a corruption ridden emerging economy, where only the US firm is subject to FCPA regulations. We demonstrate the following. (i) While an increase in fines under FCPA reduces overall corruption, it leads to a deterioration in the market quality in an emerging economy. (ii) If the products are substitutes (complements), overall corruption increases (decreases) and market quality in the emerging economy improves (deteriorates) with stricter enforcement of FCPA. (iii) An increase in the US firm's technological advantage unambiguously leads to a decrease in the market quality.
The Influence of Family Economic Status on Literacy Ability of Early School-Aged Children: The Mediating Effect of Parental Involvement

The impact of family economic status on children's development has been widely concerned in recent years. However, the influence of the basic cognitive ability of early school-aged children and its mechanism need to be further studied. In this study, 120 early school-aged children were tested with the revised "Family Economic Status Questionnaire", "Parental Involvement Questionnaire" and "Children's Literacy Ability Test", and found the mediating effect of parental involvement on the relationship between family economic status and children's literacy ability. The results showed that: (1) family economic status can positively predict the literacy ability of early school-aged children(r=0.27, p<0.05); (2) parental involvement plays the completely mediating effect in the impact of family economic status on the literacy ability of early school-aged children.
Factors predicting pneumonia in patients admitted with spontaneous supratentorial intracerebral hemorrhage in western region of Nepal

Introduction: Despite the well-documented association of stroke-associated complications and infections with increased mortality, morbidity and worse long-term outcome, there are only limited data available on independent predictors of pneumonia in patients with acute intracerebral hemorrhage. In this study, our objective was to evaluate risk factors and comorbid conditions associated with the diagnosis of hospital acquired pneumonia in the patients admitted with spontaneous intracerebral hemorrhage and to determine the independent predictors of pneumonia in these patients. Methods: A retrospective analysis was done in patients admitted in Intensive Care Unit of Nepalgunj Medical College with spontaneous intracerebral hemorrhage. Various clinic-demographic parameters were tested for association with pneumonia or no pneumonia group using chi square or student’s “t” test. Results: A total of 117 patients, 86 men (73.5%) and 31 women (26.5%) with spontaneous intracerebral hemorrhage were included in the study. There were 36 (30.77%) patients with pneumonia. The association Diabetes mellitus (p<0.01), COPD (p<0.01), smoking (p<0.01), mean GCS (p<0.01), ICH volume (p=0.01), ICH score (p<0.01), operated status (p<0.01), Ganglionic (<0.01), Brain stem (p=0.03) and Ventricular (p=0.01) location of hematoma was statistically significant with pneumonia. Outcome in terms of MRS at discharge was also poorer for patients with pneumonia (p=0.01). Conclusion: Diabetes mellitus, COPD, mean GCS, ICH volume, ICH score, operated status, higher MRS score were associated with increased risk of pneumonia in ICH. Similarly, ganglionic hematoma, brainstem hematoma and those having intraventricular hemorrhages are also associated with increased risk of pneumonia. Outcome in patients in terms of MRS were also poorer in those who had pneumonia.
Morphological and Molecular Characterization of Alternaria Species Isolated from Different Plants

Alternaria belongs to the family of Pleosporaceae, the order of Pleosporales, the class of Dothideomycetes in the phyllum of Ascomycota. This fungal genus is characterized by its ability to produce a number of enzymes able to injured many types of crops. The symptoms of Alternaria blight on different agricultural crops such as cabbage, cauliflower, coriander, fenugreek, brinjal, onion, faba bean, dahlia, dracaena, hollyhock, carrot, marigold, tomato and wheat were observed. Alternaria produces distinctive "bulls eye" patterned leaf spots in almost all the infected plants. Nineteen Alternaria isolates were obtained from fourteen infected plant samples. The observations were recorded from the seven day old culture for colony characteristics on PDA. Based on morphology 10 isolates of Alternaria alternata, two isolates Alternaria tenuissima and Alternaria longipes and one Alternaria porri, Alternaria brassicae, Alternaria brassicicola and Alternaria sp. were identified. Alternaria species grow rapidly and produced flat, downy to woolly grayish green to black colonies. All the isolates exhibited characteristics dark-coloured multicelled conidia with longitudinal and transverse septa (phaeo-dictyospores) and a beak or tapering apical cells. DNA isolation of all isolates of Alternaria was carried out using CTAB method. Isolated DNA was subjected to amplification with ITS1 and ITS4 primers in a thermal cycler. The amplified products ranged from 580-600bp. These amplified products were sequenced and identify the species of different Alternaria isolates using BLASTn in NCBI online. All the sequences were published in NCBI public domain. The resulting sequences of all isolates were compared to other sequences in the GenBank as 90-100% identical. Genetic variability was conducted by phylogenetic analysis.
SYNGAS DERIVED FROM CATALYTIC GASIFICATION OF FINE COAL WASTE USING INDONESIAN POTENTIAL CATALYST

Fine coal waste from the coal mining process has not been used as clean energy even though the amount is very abundant in the world. The conversion of fine coal to syngas is a new way to increase the value of fine coal. Syngas composition, gas ratio, gasification efficiency, and heating value of syngas have been determined under various conditions of temperature (550-750 °C) and bentonite catalyst ratio (0-0.25). The results indicate that fine coal is the suitable raw material for the gasification process. At the highest temperature (750 °C), the gas composition consists of 42.6 vol% H2, 19.1vol% CO, 19.5 vol% CH4, and 7.9vol% CO2. The best performance was achieved when the catalyst/feed ratio is 0.25 with the gas composition of 54.3vol% H2, 26.2vol% CO, 23.8 vol% CH4, and 3.5vol% CO2, heating value and gasification efficiency were 19.72 MJ/Nm3 and 72.27% at 750 °C.
Validity and Reliability of Instrument Competencies Framework of Agriculture Educators: The Rasch Measurement Model

: This study aims to produce empirical evidence of the validity and reliability of instrument items for the competency framework of agricultural teaching staff in Malaysian agricultural vocational colleges. The validity and reliability of the framework were analyzed using Rasch Model Measurement assisted by Winsteps 3.72 software. This research instrument contained 116 items, which was distributed to 30 instructors at the Teluk Intan Agricultural Vocational College, Malaysia. The selection of respondents was made by strata random where the researcher makes the strata of the population according to the percentage and then selects randomly based on the desired percentage. Validity analysis of the instrument was done through four functional testings. For reliability and separation of respondents, it was found that the individual reliability value was very good and acceptable. The results of the item polarity analysis detected no negative value (-) in the Point Measure Correlation value. Item matching analysis found that 11 items had to be dropped as they failed to meet the required conditions. From the analysis on local dependence that determines dependent items based on the standardized residual correlation value, it was discovered that the correlation value for the items used was detected; 13 items need attention. The results of the data analysis checking the functionality of the items suggested that some items should be dropped. The omission of these items has provided evidence that the instrument of competence of agricultural instructors is crucial to have a high level of validity and reliability for use in actual studies.
Evaluation Scores for Probabilistic Networks

To establish its practical value, a probabilistic network is typically subjected to an evaluation study using real-life data from the domain of application. The results of such a study are often summarised in the percentage of correctly computed outcomes. In this paper, we propose the use of evaluation scores as an alternative way of expressing the practical value of a network. These scores take not just the computed outcome into consideration but also the associated distribution of uncertainty. We illustrate the use of such a score for a real-life probabilistic network in oncology and show that it can provide valuable information in addition to a percentage correct.
Robust Trilateration Based Algorithm for Indoor Positioning Systems

Abstract Indoor Positioning Systems (IPS) plays crucial roles in indoor environment items positioning used in self-navigating robots and helping hands. To obtain position information, positioning algorithms employing Received Signal Strength Indicator (RSSI) are of great benefits since they reuse the existing radio wireless infrastructures for indoor positioning. However, the changes in the indoor environment decrease the overall accuracy of the developed indoor positioning algorithms. To cope with the challenge of environmental dependency in indoor positioning, a robust algorithm using radio signal identification was developed. The algorithm uses circle expansion and reduction mechanism to achieve better RSSI-Distance relationship. The distances from RSSI-Distance relationship are used in trilateration algorithm for position estimation. Experiments were performed to compare position accuracy of the basic RSSI-Based and the proposed algorithm. Simulation results showed that proposed algorithm showed less average positioning errors by 11.2066% and 3.7279% at path loss coefficients of 3.11 and 3.21, respectively compared to the existing algorithms. Likewise, the proposed algorithm showed 2.7282% increase in positioning error when environment was changed from that of path loss coefficient 3.11 to 3.21. The existing basic algorithms show error fluctuation of 10% with the same environment changes. Keywords: Indoor Positioning System; RFID; RSSI; Trilateration
Robust Zirconium Phosphate–Phosphonate Nanosheets Containing Palladium Nanoparticles as Efficient Catalyst for Alkynes and Nitroarenes Hydrogenation Reactions

Thin nanosheets based on layered zirconium mixed phosphate–phosphonate of formula Zr2(PO4)[(PO3CH2)2NCH2COOH]2·H2O were obtained by exfoliation in aqueous solution of propylamine of the pristine crystalline precursor. Highly dispersed palladium nanoparticles, of 2–5 nm average size, were generated using palladium acetate as Pd source please change "as precursor" with "as Pd source" and immobilized on the nanosheet surface. The resulting layered nanohybrids differ in the palladium loading (from 5 to 22% in weight of Pd) and in the amount of propylamine intercalated between the nanosheets. The new 2D material was investigated as catalyst in the partial hydrogenation of C≡C bonds and in the selective reduction of nitroarenes, showing very good selectivity at full conversion under room temperature, with pretty constant activity upon recycle. Metal leaching in solution was negligible as well as no additives nor regeneration steps were needed for repeated use.