Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Phytomedicines on Wound Healing

The interrelationship between wound healing and phytomedicines is a long past concept that has been practiced since time immemorial and still is being considered as one of the most reliable sources of curing wounds. The process of wound healing is not a very quick process rather it is a matter of multiple steps that are involved in the process of wound healing like homeostasis and inflammation, proliferation and remodelling. A number of phytomedicines have been discovered since the primitive people were on hunt for wound cure, some of which are curcumins, picrolivs, arbenins, aloe vera etc. The beautiful science that is inducing these phytomedicines to the site of damage is something that is very fascinating. Phytomedicines are not only used in wound healing but also in numerous other treatments. Thus, phytomedicines are considered to be the future of medical aid because of the almost negligible side effects that it has in comparison to synthetic medicines.
Potassium Channels in the Vascular Diseases

The vessel wall is an intricate structure composed of three layers: the intima (consisting of endothelial cells), media (consisting of smooth muscle cells and elastic fibers), and externa (consisting of the extracellular matrix scaffold). The homeostasis of the vasculature depends on the consistent function of each layer. In the vascular system, potassium channels are well known to regulate vascular function. The interactions between vascular conditions and membrane potential are complicated. In this chapter, we will focus on the functional regulation of KCa channel, KATP channel, and KV channel in the vascular system. Researchers may continuously obtain insights into the functions of these channels and identify new therapeutic targets for vascular diseases.
B.1.258$Δ$, a SARS-CoV-2 variant with $Δ$H69/$Δ$V70 in the Spike protein circulating in the Czech Republic and Slovakia

SARS-CoV-2 mutants carrying the $Δ$H69/$Δ$V70 deletion in the amino terminal domain of the Spike protein emerged independently in at least six lineages of the virus (namely, B.1.1.7, B.1.1.298, B.1.160, B.1.177, B.1.258, B.1.375). Routine RT-qPCR tests including TaqPath or similar assays based on a drop-out of the Spike gene target are incapable of distinguishing among these lineages and often lead to the false conclusion that clinical samples contain the B.1. 1.7 variant, which recently emerged in the United Kingdom and is quickly spreading through the human population. We analyzed SARS-CoV-2 samples collected from various regions of Slovakia between November and December 2020 that were presumed to contain the B.1. 1.7 variant due to traveling history of the virus carriers or their contacts. Sequencing of these isolates revealed that although in some cases the samples were indeed confirmed as B.1. 1.7, a substantial fraction of isolates contained another $Δ$H69/$Δ$V70 carrying mutant belonging to the lineage B.1. 258, which has been circulating in Central Europe since August 2020, long before the import of B.1. 1.7. Phylogenetic analysis shows that the early sublineage of B.1. 258 acquired the N439K substitution in the receptor binding domain (RBD) of the Spike protein and, later on, also the deletion $Δ$H69/$Δ$V70 in the Spike N-terminal domain (NTD). This variant is particularly common in several European countries including Czech Republic and Slovakia, and we propose to name it B.1. 258$Δ$.
The immunogenicity of polyclonal antibody from induced Vibrio parahaemolyticus membrane by Elisa method

Polyclonal antibodies are antibody proteins formed from interaction between antigens that enter a body. It results in immunogenicity. The process of generating polyclonal antibodies begins with purifying a membrane protein. A membrane protein that is potential to make an antibody is the outer membrane protein (OMP) of bacterium V. parahaemolyticus. These proteins are injects into an animal’s body as the target antigen so that an antibody can be produced. The antibody was obtained by taking the animal’s blood sample. It is then isolated in a serum until it generates a polyclonal antibody. ELISA (Enzyme-Linked Immunosorbent Assay) is a technique normally used to measure the concentration of an antibody or an antigen in blood or to detect their existence in a sample. The aim of this research was to analyse the immunogenicity of polyclonal antibodies produced from Vibrio Parahaemolyticus membranes that was induce using ELISA method. Research findings indicate that the highest OD value of ELISA (0, 404) was obtained on the third week of 1/100 dilution. The highest value of antigens and antibodies interaction was found on 1/100 dilution. Immunization before booster generated relatively small antibody titres because the rat’s body was not ready to provide an immune response.
Kinematically complete experiments for electron induced break-up of small molecules and clusters

The electron collision induced ionization and fragmentation dynamics is studied for tetrafluoromethane (CF4), carbondioxide (CO2) and small water clusters (H2O)n (n ≤ 6). With a multi-particle imaging spectrometer for each collision two electrons and one ion were recorded in triple-coincidence. The dissociation dynamics of CF4 was analyzed as a function of the ionized orbitals. For the CO2 target the angular emission pattern of the ejected electron was studied as function of the projectile scattering kinematics. Fully differential cross sections were recorded to test a recently developed theoretical method. In addition ionization experiments for small water clusters revealed details on their stability, ionization energies and proton transfer reactions. Specific states of the stable dimers ions where observed for the first time.
Practical Aspects of Cyclic Voltammetry: How to Estimate Reduction Potentials When Irreversibility Prevails

What is the best approach for estimating standard electrochemical potentials, E (0) , from voltammograms that exhibit chemical irreversibility? The lifetimes of the oxidized or reduced forms of the majority of known redox species are considerably shorter than the voltammetry acquisition times, resulting in irreversibility and making the answer to this question of outmost importance. Half- wave potentials, E (1/2) , provide the best experimentally obtainable representation of E (0) . Due to irreversible oxidation or reduction, however, the lack of cathodic or anodic peaks in cyclic voltammograms renders E (1/2) unattainable. Therefore, we evaluate how closely alternative potentials, readily obtainable from irreversible voltammograms, estimate E (0) . Our analysis reveals that, when E (1/2) is not available, inﬂection-point potentials provide the best characterization of redox couples. While peak potentials are the most extensively used descriptor for irreversible systems, they deviate signiﬁcantly from E (0) , especially at high scan rates. Even for partially irreversible systems, when the cathodic peak is not as pronounced as the anodic one, the half-wave potentials still provide the best estimates for E (0) . The importance of these ﬁndings extends beyond the realm of electrochemistry and impacts ﬁelds, such as materials engineering, photonics, cell biology, solar energy engineering and neuroscience, where cyclic voltammetry is a key tool.
Evaluation of Physicochemical, Nutritional and Sensory Properties of the Wet Tarhana

The wet tarhana is a fermented product that prepared with wheat flour, yogurt, tarhana herb ( Echiophora sibthorpiana ) and some chopped vegetables and spices. The basic difference of wet tarhana from other tarhana types is that it is prepared without a drying step. During its spontaneous fermentation process about 10 days, yogurt bacteria ( Streptococcus thermophilus and Lactobacillus bulgaricus ) produce several organic acids such as lactic acid and some other organic compounds. The ingredients and long fermentation process gain characteristic flavor and unique taste to the tarhana. Tarhana is similar to sourdough due to its' long spontaneous fermentation time. The aim of the study was to investigate physicochemical, nutritional and microbiological properties of wet tarhana, and to evaluate the relationships between them. For this purpose, wet tarhana samples were collected from different districts, and some physicochemical properties (pH, total acidity, dry matter, fat, and soluble ash content), antioxidant activity, phytic acid content, bioavailability, viscosity and counts of microbiota were performed. The results showed that the level of mineral digestibility was ranged from 67.22% to 88.88%, and a negative correlation was determined between mineral bioavailability and phytic acid content. The vitality of the microbiota especially lactic acid bacteria maintained during the storage period. Moreover, tarhana soups were prepared with the samples and their viscosity and sensory assessment were performed. Although the wet tarhana and soup samples had different viscosities initially, all the samples indicated pseudoplastic flow behavior. Furthermore, it was determined that the physicochemical properties of the samples affected the preference of the panelists in terms of sensorial assessment. Keywords: tarhana, fermented products, bioavailability, viscosity DOI : 10.7176/FSQM/83-08
Comparative research of the curative effects of pinelliae rhizoma and pinelliae rhizoma praeparatum cum alumine on ovalbumin-induced allergic asthma in rats

Aim: This study was designed to compare the curative effects of Pinelliae Rhizoma (RPT) and Pinelliae Rhizoma Praeparatum cum Alumine (QPT) on ovalbumin (OVA)-induced allergic asthma in rats. Materials and Methods: Asthmatic rats were prepared by intraperitoneal injection and inhalation of OVA, and RPT and QPT at the doses of 120 and 240 mg/kg/day were administered orally for consecutive 7 days. Then, histopathological changes of the lung tissues were examined; levels of interleukin (IL)-4 and interferon (IFN)-γ in the bronchoalveolar lavage fluids (BALFs) and immunoglobulin (Ig) E in the serum were measured by enzyme-linked immunosorbent assay; eosinophils (EOS) in BALFs were also determined. Furthermore, the expressions of mucin 5AC (MUC5AC) and AQP-5 in the lung tissues were determined by quantitative real-time fluorogenic polymerase chain reaction and western blot assays. Besides, high-performance liquid chromatography-LTQ-Orbitrap-Elite-MS analysis was applied to compare the constituent's difference between the RPT and QPT. Results: The present results revealed that both the RPT and QPT have the potential curative effects for treating OVA-induced asthma in rats via inhibiting inflammatory reactions (suppressing EOS influx, IgE secretion, and release of IL-4 whereas increasing the release of IFN-γ) and modulating the mRNA and protein expressions of MUC5AC and AQP-5. In addition, our results also evidenced that QPT exhibited a better curative effect on allergic asthmatic rats compared to RPT. Conclusion: Our results are beneficial for confirming the traditional Chinese medicinal theory of “QPT is good at removing dampness to reduce phlegm. ” Abbreviations used: BALF: Bronchoalveolar lavage fluid; ELISA: Enzyme-linked immunosorbent assay; EOS: Eosinophils; IFN: Interferon; IL: Interleukin; OVA: Ovalbumin; qRT-PCR: Quantitative real-time fluorogenic polymerase chain reaction; QPT: Rhizoma Pinelliae Praeparatum cum Alumine; RIPA: Radioimmunoprecipitation assay; RPT: Pinelliae Rhizoma; SDS-PAGE: Sodium dodecyl sulfate-polyacrylamide gel electrophoresis; TCM: Traditional Chinese medicine.
Determining the link between Chronic Periodontitis and Abdominal Aortic Aneurysm: A questionnaire-based study

Syfte: Syftet med studien var att se om det fanns en correlation mellan AAA och kronisk parodontit med hjalp av en enkat. Material och metod: Man som har undergatt screening hos Karlcentrum vid Skanes Universitetssjukhus i Malmo erbjods deltagande i studien via telefon. Enkaten som anvandes formulerades framst med fragor fran studien i Self-reported measures for Surveillance of Periodontitis (Eke et al. 2013). Fragor om individens tobaksvanor, om den led av andra sjukdomar, och mediciner lades till som en del av denna studie. Insamlad data analyserades med IBM SPSS Statistics 25 (SPSS Inc., Chicago, IL, USA. Ingen normalfordelning antogsfor analyserna. Vardena bearbetades med Mann-Whitney U test och χ2-test. P-varden < 0.05 togs som statistiskt signifikanta. Resultat: Totalt kontaktades 300 individer, varav 65 (21.7%) inkluderades i studien. Av dessa var 42 (64.6 %) individer i kontrollgruppen medans 23 (35.4%) ingick i AAA-gruppen.Bennedbrytning forekom oftare i AAA gruppen (37.9%) jamfort med kontrollgruppen (11.9%) (p=0.010) Slutsats: En svag lank mellan kronisk parodontit och AAA kan foreslas i detta skede, dock behovs fler studier med storre kohort och om mojligt en kliniskt verifierad parodontal diagnos for att med sakerthet bekrafta denna potentiella lanken
Speciation and reduction of U(VI) in acidic chloride brines under hydrothermal conditions: From transport to deposition of uranium in unconformity-related deposits

Circulations of acidic chloride brines are associated with unconformity-related uranium (URU) deposits. The spectacular high grade combined with the large tonnage of these deposits is at the origin of the key questions concerning the geological processes responsible for U transport and precipitation. The aim of this work is to performed experimental studies of U6+ speciation and its reduction to U4+ subsequently precipitation to UO2 under hydrothermal condition. About U transport, the study of U6+ speciation in acidic brines at high temperature is performed by Raman spectroscopy and XAS, showing the coexistence of several uranyl chloride complexes UO2Cln2-n (n=0-5). From this study, complexation constants are proposed. The strong capability of chloride to complex uranyl is at the origin of the transport of U6+ at high concentration in acidic chloride brines. Concerning U precipitation, the reactivity of four potential reductants under conditions relevant for URU deposits genesis is investigated: H2, CH4, Fe2+ and the C-graphite. The kinetics of reduction reaction is measured as a function of temperature, salinity, pH and concentration of reductant. H2, CH4, and the C-graphite are very efficient while Fe2+ is not able to reduce U6+ in same conditions. These mobile and efficient gaseous reductant could be at the origin of the extremely focus and massive character of ore in URU deposits. Finally, first partition coefficients UO2/fluid of trace elements are obtained. This last part opens-up new perspectives on (i) REE signatures interpretation for a given type of U deposit (ii) and reconstruction of mineralizing fluids composition
Mitigating Advanced Persistent Threats: A Comparative Evaluation Review

Cyber threats have been an issue of great concern since the advent of the information (computer and internet) age. But of greater concern is the most recent class of threats, known as Advanced Persistent Threats (APTs). It has drawn increasing attention all over the world, from researchers, and the industrial security sector. APTs are sophisticated cyber-attacks executed by sophisticated and well-resourced adversaries targeting speciﬁc information in companies and government. APT is a long-term campaign involving different steps. This form of attack if successful has significant implications to countries and large organizations, which may be from financial to reputational damage. This work presents a comprehensive study on APT, characterizing its uniqueness and attack model, and analyzing techniques commonly seen in APT attacks. On evaluating mitigation effects proposed and developed by researches, the use of a multiple mitigation methods shows good signs in detecting and preventing APT. Anomaly detection and dynamic analysis show high accuracy levels in detecting APT. This work also highlights and recommends security tips as well as methods of implementing countermeasures that can help to mitigate APTs, thereby giving directions for future research.
INDIGENOUS VOLATILE OILS AS IMPERATIVE GIFT FROM NATURE - A REVIEW

Volatile oils are concentrated odorous essences extracted from various plant parts such as flowers, fruits, heart-wood, rhizome and leaves. They are frequently employed in food flavoring, perfume, medicine and aromatherapy. Essential oils are extracted from various processes such as hydro distillation, effleurage and eucelle depending upon the plant part containing the essential oil. Essential oils are inhaled in the form of fine mist of vapour through aromatherapy and some of them are highly beneficial when ingested. These oils have been used traditionally for preservation of foods, spices and condiments. Essential oils or ethereal oils are natural, complex, multi-component, highly concentrated essences of aromatic plant systems composed mainly of terpenes units in addition to some other non-terpene components. These units biosynthesized by mevalonic acid pathway. Isoprenes/hemi-terpenes are five carbon compound having two unsaturated bonds. In this review paper an attempt has been done to emphasize the most valuable essential oils of Indian origin from nature with focus particularly on the chemical constituents, medicinal and pharmacological usage of volatile oils.
Bandgap engineered smart three‐terminal solar cell: New perspectives towards very high efficiencies in the silicon world

We present the design of a new architecture of three‐terminal (3‐T) photovoltaic tandem solar cells. It combines an interdigitated back contacted (IBC) bottom lateral subcell with a heterojunction vertical top cell. In this concept, the two subcells can work independently and there is no need for tunnel junctions. It is particularly well suited to silicon back contact subcells and to various types of top cell materials from III‐V compounds or perovskites. The working principle is detailed here using as an example a p/i III‐V front stack onto n‐type silicon IBC bottom cell. We perform two‐dimensional (2D) modeling using realistic material input parameters and show how interface bandgap engineering can improve the tandem cell efficiency up to a reachable 35% value. The proposed cell concept named bandgap engineered smart silicon three‐terminal (BESTT) cell can be realized with less technological steps and at a lower cost compared with the conventional four‐terminal process.
Modification of electrospun, ultra-thin cellulose fibres by means of polycarboxylic acid–based cross-linking agents

Ultra-thin fibre assemblies consisting of cellulose were prepared by means of the electrospinning procedure. In this study, cellulose acetate (CA) was dissolved in dimethylacetamide/acetone (2:1 v/v) and electrospun using a high voltage of 10 and 15 kV and a tip to collector distance of 15 cm. The CA fibre mats were deacetylated and chemically modified by means of a 1,2,3,4-butanetetracarboxylic acid (BTCA)/sodium hypophosphite and a BTCA/(3-aminopropyl)triethoxysilane (APTES) solution. After a thermal treatment at 180°C, Fourier Transform infrared/attenuated reflection spectra of the cross-linked fibre mats confirmed the formation of an ester linkage and an imide moiety, respectively. X-ray diffraction spectra made evident the presence of cellulose II. Thermogravimetric analysis indicated a significant increase in the thermal stability of the chemically modified mats. The water vapour transmission is increased for BTCA/APTES fibre mats.
Whey Protein and Nigella sativa Oil Mitigate Potassium Dichromate Induced Hepatic Injury, Oxidative Stress and Hematotoxicity in Rats

The present study was carried out to evaluate the antioxidant property of whey protein and/or Nigella sativa Oil (NSO) against hepatotoxicity evoked by potassium dichromate (K 2 Cr 2 O 7 ). Designed for this purpose, we detected the 8 weeks challenge result of whey protein (100 and 200 mg/kg, p.o) with/or without Nigella sativa oil (5ml/kg, p.o) in contradiction of poisoned albino rats with one dose of potassium dichromate (30mg/Kg, I.P) at the end of challenge period. Concerning plasma level, whey protein with/or without Nigella sativa oil were ameliorated the potassium dichromate liver damage concerns, so it exhibited a major progress in Aspartate Aminotransferase (AST), Alanine Amino Transferase (ALT), Alkaline Phosphatase (ALP), and Gamma-Glutamyl Transferase (GGT). Moreover, whey protein or Nigella sativa oil reduce the deleterious effects of potassium dichromate on Triiodothyronine (T3), Thyroxine (T4), Thyroidstimulating Hormone (TSH), glucose and Complete Blood Count (CBC). In addition, they displayed an important improvement in hepatic antioxidant enzymes, Catalase (CAT) and Superoxide Dismutase (SOD) beside reduced Glutathione (GSH), and with a subsequent decrease in Malondialdehyde (MDA) or Nitric Oxide (NO) levels in comparison with the untreated K 2 Cr 2 O 7 group. Also, whey protein with/or without Nigella sativa oil improve the histopathological alterations produced by the potassium dichromate. These outcomes suggest that whey protein or Nigella sativa oil can be used as effective antioxidant aginst potassium dichromate intoxication as they modulate liver function and decrease oxidative stress.
ASTHENOZOOSPERMIC BUFFALO (Bubalus bubalis) SPERM TAIL IS ASSOCIATED WITH LOWER EXPRESSION OF TEKTIN-2 AND SPAG6 AND HIGHER EXPRESSION OF SPECIFIC TYROSINE PHOSPHORYLATED PROTEINS

Study of motility-associated proteins is a direct approach to decode the underlying mechanisms of the motility-regulation pathway in a mammalian spermatozoon. In this aspect, attempts were made to characterize and study the expression pattern of two candidate motility-associated proteins of mammalian sperm such as Tektin-2 and SPAG6 and post-translationally modified tyrosine phosphorylated proteins between the two defined groups of buffaloes: normozoospermic (NS) and asthenozoospermic (AS). 1-D Western blot demonstrated three Tektin-2 immunoreactive bands (95.3, 55.7 and 33.0 kDa) in buffalo sperm tails. Of these, the intensity of 95.3 kDa band reduced significantly (P ≤ 0.05) in sperm tail of AS group as compared to that of NS group. Similarly, the sperm ta il demonstrated a single SPAG6-immnunoreactive band of 31.6 kDa that reduced significantly (P ≤ 0.05) in sperm tail of AS group as compared to that of NS group. Both AS and NS group sperm tail demonstrated at least five tyrosine phosphorylated proteins (89.5, 53.3, 44.5, 30.9 and 16.7 kDa). Of these, the intensity of 44.5 kDa band was significantly higher (P ≤ 0.05) in AS group as compared to that of NS group. Interestingly, within the AS group, degree of expression of 53.3 kDa tyrosine phosphorylated protein was bull-specific. The findings of the present study have demonstrated that AS group of buffalo bulls are associated with lower expression of Tektin-2 and SPAG6 and higher expression of specific tyrosine phosphorylated proteins. * Corresponding author KEYWORDS
Aplicação da escala servqual para mensuração da satisfação dos serviços prestados pelo CNA Caruaru/PE.

Currently the Brazilian economy is rooted in the service sector, through the quality to be treated as a competitive advantage and differential in the business. then the need arises, by the company in improving your quality process to its permanence and new achievements in the market. The satisfaction and quality is then formed on the customer's perspective to have their expectations and perceptions regarding the service purchased. Then comes the present study seeks to measure customer perceptions about the quality of service through the application of SERVQUAL in CNA English Final - Caruaru/PE. Presenting a critical analysis of the assessment of expectation and perception of it in order to investigate aspects and suggest proposals for continuous improvement. We conducted a descriptive quantitative and qualitative research, using the inductive method, being applied in October 2016. Based on the results, according to customer evaluation, it appears that the company serves its customers satisfactorily.