Miracle-dz/UniFAR-FTUs huggingface dataset:
A New Non-Quasi Static Mosfet Model

Recent progress in wireless communication is sustained through integrated circuit technologies that offer a low cost and low power devices that operate in the Radio Frequency (RF) range with relatively low noise figure. The submicrometer CMOS technology presents a serious alternative to the more expensive, high power GaAs and Si bipolar technologies that have been used for the design of high frequency ICs. Design testing and verification through circuit simulation is a critical step in the design cycle of RF integrated circuits (RFICs). Accurate device models are therefore required to reduce design cycles and to achieve success when the circuit is finally committed to silicon.This thesis addresses the Radio Frequency (RF) small-signal and large-signal models for the MOS transistor. The quasi-static (QS) and non-quasi-static (NQS) models are discussed and the assumptions used in their development are examined. The various charge components are briefly introduced and the source/drain charge partitioning is presented. The limitation of the QS approach at high frequency is investigated using the Bsim3v3.1 model. The development of a first order NQS small-signal model is briefly presented and its suitability for RF applications is indicated. The effect of the distributed gate, channel, and substrate resistances on the high frequency characteristics of the MOS transistor is examined. We propose a Radio Frequency small-signal equivalent circuit (EC) together with an efficient parameter extraction algorithm that is necessary for the device optimization and the development of accurate large-signal models. The validity of the proposed model and the accuracy of the extraction method are verified by comparing Pspice simulation results of the EC to experimental data and the Bsim3v3.1 model up to 10GHz.
Share Rose, Get Fun: The Influence of Donation on Happiness

There is little literature on the impact of donation on individual wellbeing in China. This study examines individual donations in China to answer the question of whether helping others makes us happier and to provide policy implications for in Chinese context. Based on the 2012 Chinese General Social Survey (CGSS) data and using ordered logit and OLS as benchmark models, this study finds that donation can significantly increase individual happiness. After using propensity score matching (PSM) to eliminate the possible impact of self-selection, the above conclusion remains robust. After a sub-sample discussion, it is found that this effect is more pronounced under completely voluntary donation behavior, and is not affected by economic factors, indicating that the happiness effect of donation does not vary significantly depending on the individual’s economic status. This study contributes to the literature on donation behavior by examining the impact of donation behavior on donors’ subjective happiness in China, and further identifies subjective happiness differences, as between voluntary and involuntary donations, thereby providing theoretical and empirical support for the formulation of policies for the development of donation institutions in China.
Case Report: Niraparib as Maintenance Therapy in A Patient With Ovarian Carcinosarcoma

Ovarian carcinosarcoma (OCS) is a rare, highly aggressive and rapidly progressing malignant tumor with an extremely poor prognosis. So far, due to the low incidence of OCS, there are no large-scale prospective studies exploring the standard care of OCS patients. There is no uniform and effective treatment for OCS. Within the development of precision medicine, targeted therapies (such as PARP inhibitors) have been widely used in epithelial ovarian cancer and various other solid tumors. Here, we report a BRCAwt patient with advanced OCS who experienced a second and a third cytoreductive surgery in June 2017 and October 2019 and has been on niraparib maintenance therapy for more than 20 months after receiving second-line and third-line chemotherapy.
Functionally Assessing the Age-Related Decline in the Detection Rate of Photons by Cone Photoreceptors

Age-related decline in visual perception is usually attributed to optical factors of the eye and neural factors. However, the detection of light by cones converting light into neural signals is a crucial intermediate processing step of vision. Interestingly, a novel functional approach can evaluate many aspects of the visual system including the detection of photons by cones. This approach was used to investigate the underlying cause of age-related visual decline and found that the detection rate of cones was considerably affected with healthy aging. This functional test enabling to evaluate the detection of photons by cones could be particularly useful to screen for retinal pathologies affecting cones such as age-related macular degeneration. However, the paradigm used to functionally measure the detection of photons was complex as it was evaluating many other properties of the visual system. The aim of the current mini review is to clarify the underlying rationale of functionally evaluating the detection of photons by cones, describe a simpler approach to evaluate it, and review the impact of aging on the detection rate of cones.
Structural Characterization of the Highly Restricted Down Syndrome Critical Region on 21q22.13: New KCNJ6 and DSCR4 Transcript Isoforms

Down syndrome (DS) is caused by trisomy of chromosome 21 and it is the most common genetic cause of intellectual disability (ID) in humans. Subjects with DS show a typical phenotype marked by facial dysmorphisms and ID. Partial trisomy 21 (PT21) is a rare genotype characterized by the duplication of a delimited chromosome 21 (Hsa21) portion and it may or may not be associated with DS diagnosis. The highly restricted Down syndrome critical region (HR-DSCR) is a region of Hsa21 present in three copies in all individuals with PT21 and a diagnosis of DS. This region, located on distal 21q22.13, is 34 kbp long and does not include characterized genes. The HR-DSCR is annotated as an intergenic region between KCNJ6-201 transcript encoding for potassium inwardly rectifying channel subfamily J member 6 and DSCR4-201 transcript encoding Down syndrome critical region 4. Two transcripts recently identified by massive RNA-sequencing (RNA-Seq) and automatically annotated on Ensembl database reveal that the HR-DSCR seems to be partially crossed by KCNJ6-202 and DSCR4-202 isoforms. KCNJ6-202 shares the coding sequence with KCNJ6-201 which is involved in many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells. DSCR4-202 transcript has the first two exons in common with DSCR4-201, the only experimentally verified gene uniquely present in Hominidae. In this study, we performed in silico and in vitro analyses of the HR-DSCR. Bioinformatic data, obtained using Sequence Read Archive (SRA) and SRA-BLAST software, were confirmed by Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and Sanger sequencing on a panel of human tissues. Our data demonstrate that the HR-DSCR cannot be defined as an intergenic region. Further studies are needed to investigate the functional role of the new transcripts, likely involved in DS phenotypes.
RIG-I and MDA5 Protect Mice From Pichinde Virus Infection by Controlling Viral Replication and Regulating Immune Responses to the Infection

RIG-I and MDA5 are major cytoplasmic innate-immune sensor proteins that recognize aberrant double-stranded RNAs generated during virus infection to activate type 1 interferon (IFN-I) and IFN-stimulated gene (ISG) expressions to control virus infection. The roles of RIG-I and MDA5 in controlling replication of Pichinde virus (PICV), a mammarenavirus, in mice have not been examined. Here, we showed that MDA5 single knockout (SKO) and RIG-I/MDA5 double knockout (DKO) mice are highly susceptible to PICV infection as evidenced by their significant reduction in body weights during the course of the infection, validating the important roles of these innate-immune sensor proteins in controlling PICV infection. Compared to the wildtype mice, SKO and DKO mice infected with PICV had significantly higher virus titers and lower IFN-I expressions early in the infection but appeared to exhibit a late and heightened level of adaptive immune responses to clear the infection. When a recombinant rPICV mutant virus (rPICV-NPmut) that lacks the ability to suppress IFN-I was used to infect mice, as expected, there were heightened levels of IFN-I and ISG expressions in the wild-type mice, whereas infected SKO and DKO mice showed delayed mouse growth kinetics and relatively low, delayed, and transient levels of innate and adaptive immune responses to this viral infection. Taken together, our data suggest that PICV infection triggers activation of immune sensors that include but might not be necessarily limited to RIG-I and MDA5 to stimulate effective innate and adaptive immune responses to control virus infection in mice.
Integrated Library Systems and Dis-Integrative Pressures

Automated library systems began small and have consistently, if not steadily, traced an arc from less to more integration. Economies of scale, a desire not to duplicate data unnecessarily, and the advantages of smooth and complete integration have been unanswerable arguments as applications have grown from single-purpose utilities to fully integrated systems, providing a wide array of core services to libraries. But throughout this history, there have also always been arguments in favour of less integration and more specialisation of function. Monolithic systems cannot provide the level of quality in many features that a small, focused implementation can in one, nor does a unified system offer as much opportunity for customisation and flexibility as one assembled from "best of class" applications. The tension between these two alternative views has been and will continue to be an important factor in the development of library systems. As the mission of libraries expands and brings with it a proliferation of automated systems, the need to integrate them will almost certainly prove stronger than the desire for superior functionality. But system developers must take into account the requirement for flexibility or they will alienate some of their most gifted potential users. Keyword: Intergraded Library System, Library Automation, Library System
11 Pressing Research Questions on How Light Pollution Affects Biodiversity

Artificial light at night (ALAN) is closely associated with modern societies and is rapidly increasing worldwide. A dynamically growing body of literature shows that ALAN poses a serious threat to all levels of biodiversity—from genes to ecosystems. Many “unknowns” remain to be addressed however, before we fully understand the impact of ALAN on biodiversity and can design effective mitigation measures. Here, we distilled the findings of a workshop on the effects of ALAN on biodiversity at the first World Biodiversity Forum in Davos attended by several major research groups in the field from across the globe. We argue that 11 pressing research questions have to be answered to find ways to reduce the impact of ALAN on biodiversity. The questions address fundamental knowledge gaps, ranging from basic challenges on how to standardize light measurements, through the multi-level impacts on biodiversity, to opportunities and challenges for more sustainable use.
Novel SCN5A and GPD1L Variants Identified in Two Unrelated Han-Chinese Patients With Clinically Suspected Brugada Syndrome

Brugada syndrome (BrS) is a complexly genetically patterned, rare, malignant, life-threatening arrhythmia disorder. It is autosomal dominant in most cases and characterized by identifiable electrocardiographic patterns, recurrent syncope, nocturnal agonal respiration, and other symptoms, including sudden cardiac death. Over the last 2 decades, a great number of variants have been identified in more than 36 pathogenic or susceptibility genes associated with BrS. The present study used the combined method of whole exome sequencing and Sanger sequencing to identify pathogenic variants in two unrelated Han-Chinese patients with clinically suspected BrS. Minigene splicing assay was used to evaluate the effects of the splicing variant. A novel heterozygous splicing variant c.2437-2A>C in the sodium voltage-gated channel alpha subunit 5 gene (SCN5A) and a novel heterozygous missense variant c.161A>T [p.(Asp54Val)] in the glycerol-3-phosphate dehydrogenase 1 like gene (GPD1L) were identified in these two patients with BrS-1 and possible BrS-2, respectively. Minigene splicing assay indicated the deletion of 15 and 141 nucleotides in exon 16, resulting in critical amino acid deletions. These findings expand the variant spectrum of SCN5A and GPD1L, which can be beneficial to genetic counseling and prenatal diagnosis.
Do Incubation Temperatures Affect the Preferred Body Temperatures of Hatchling Velvet Geckos?

In many lizards, a mother’s choice of nest site can influence the thermal and hydric regimes experienced by developing embryos, which in turn can influence key traits putatively linked to fitness, such as body size, learning ability, and locomotor performance. Future increases in nest temperatures predicted under climate warming could potentially influence hatchling traits in many reptiles. In this study, we investigated whether future nest temperatures affected the thermal preferences of hatchling velvet geckos, Amalosia lesueurii. We incubated eggs under two fluctuating temperature treatments; the warm treatment mimicked temperatures of currently used communal nests (mean = 24.3°C, range 18.4–31.1°C), while the hot treatment (mean = 28.9°C, range 20.7–38.1°C) mimicked potential temperatures likely to occur during hot summers. We placed hatchlings inside a thermal gradient and measured their preferred body temperatures (Tbs) after they had access to food, and after they had fasted for 5 days. We found that hatchling feeding status significantly affected their preferred Tbs. Hatchlings maintained higher Tbs after feeding (mean = 30.6°C, interquartile range = 29.6–32.0°C) than when they had fasted for 5 d (mean = 25.8°C, interquartile range = 24.7–26.9°C). Surprisingly, we found that incubation temperatures did not influence the thermal preferences of hatchling velvet geckos. Hence, predicting how future changes in nest temperatures will affect reptiles will require a better understanding of how incubation and post-hatchling environments shape hatchling phenotypes.
Research Progress of Carrier-Free Antitumor Nanoparticles Based on Phytochemicals

Cancer is a major worldwide public health issue, responsible for millions of deaths every year. Cancer cases and deaths are expected to increase rapidly with population growth, age, and lifestyle behaviors that increase cancer risk. Long-term chemotherapy results in acquired drug resistance. Traditional treatment methods have limitations and cannot effectively treat distal metastatic cancers. Application of nanocarriers in multi-chemotherapy must be promoted. With research progress, the shortcomings of traditional nanocarriers have gradually become evident. Carrier-free nanodrugs with desirable bioactivity have attracted considerable attention. In this review, we provide an overview of recent reports on several carrier-free nanodrug delivery systems based on phytochemicals. This review focuses on the advantages of carrier-free nanodrugs, and provides new insights for establishment of ideal cancer treatment nanosystems.
New strategies for low noise, agile PLL frequency synthesis

Phase-Locked Loop based frequency synthesis is an essential technique employed in wireless communication systems for local oscillator generation. The ultimate goal in any design of frequency synthesisers is to generate precise and stable output frequencies with fast switching and minimal spurious and phase noise. The conflict between high resolution and fast switching leads to two separate integer synthesisers to satisfy critical system requirements. This thesis concerns a new sigma-delta fractional-N synthesiser design which is able to be directly modulated at high data rates while simultaneously achieving good noise performance. Measured results from a prototype indicate that fast switching, low noise and spurious free spectra are achieved for most covered frequencies. The phase noise of the unmodulated synthesiser was measured −113 dBc/Hz at 100 kHz offset from the carrier. The intermodulation effect in synthesisers is capable of producing a family of spurious components of identical form to fractional spurs caused in quantisation process. This effect directly introduces high spurs on some channels of the synthesiser output. Numerical and analytic results describing this effect are presented and amplitude and distribution of the resulting fractional spurs are predicted and validated against simulated and measured results. Finally an experimental arrangement, based on a phase compensation technique, is presented demonstrating significant suppression of intermodulation-borne spurs. A new technique, pre-distortion noise shaping, is proposed to dramatically reduce the impact of fractional spurs in fractional-N synthesisers. The key innovation is the introduction in the bitstream generation process of carefully-chosen set of components at identical offset frequencies and amplitudes and in anti-phase with the principal fractional spurs. These signals are used to modify the Σ-Δ noise shaping, so that fractional spurs are effectively cancelled. This approach can be highly effective in improving spectral purity and reduction of spurious components caused by the Σ-Δ modulator, quantisation noise, intermodulation effects and any other circuit factors. The spur cancellation is achieved in the digital part of the synthesiser without introducing additional circuitry. This technique has been convincingly demonstrated by simulated and experimental results.
Functional Hydrogel Dressings for Treatment of Burn Wounds

The therapy of burns is a challenging clinical issue. Burns are long-term injuries, and numerous patients suffer from chronic pain. Burn treatment includes management, infection control, wound debridement and escharotomy, dressing coverage, skin transplantation, and the use of skin substitutes. The future of advanced care of burn wounds lies in the development of “active dressings”. Hydrogel dressings have been employed universally to accelerate wound healing based on their unique properties to overcome the limitations of existing treatment methods. This review briefly introduces the advantages of hydrogel dressings and discusses the development of new hydrogel dressings for wound healing along with skin regeneration. Further, the treatment strategies for burns, ranging from external to clinical, are reviewed, and the functional classifications of hydrogel dressings along with their clinical value for burns are discussed.
Potential Role of Plant Growth Regulators in Administering Crucial Processes Against Abiotic Stresses

Plant growth regulators are naturally biosynthesized chemicals in plants that influence physiological processes. Their synthetic analogous trigger numerous biochemical and physiological processes involved in the growth and development of plants. Nowadays, due to changing climatic scenario, numerous biotic and abiotic stresses hamper seed germination, seedling growth, and plant development leading to a decline in biological and economic yields. However, plant growth regulators (PGRs) can potentially play a fundamental role in regulating plant responses to various abiotic stresses and hence, contribute to plant adaptation under adverse environments. The major effects of abiotic stresses are growth and yield disturbance, and both these effects are directly overseen by the PGRs. Different types of PGRs such as abscisic acid (ABA), salicylic acid (SA), ethylene (ET), and jasmonates (JAs) are connected to boosting the response of plants to multiple stresses. In contrast, PGRs including cytokinins (CKs), gibberellins (GAs), auxin, and relatively novel PGRs such as strigolactones (SLs), and brassinosteroids (BRs) are involved in plant growth and development under normal and stressful environmental conditions. Besides, polyamines and nitric oxide (NO), although not considered as phytohormones, have been included in the current review due to their involvement in the regulation of several plant processes and stress responses. These PGRs are crucial for regulating stress adaptation through the modulates physiological, biochemical, and molecular processes and activation of the defense system, upregulating of transcript levels, transcription factors, metabolism genes, and stress proteins at cellular levels. The current review presents an acumen of the recent progress made on different PGRs to improve plant tolerance to abiotic stress such as heat, drought, salinity, and flood. Moreover, it highlights the research gaps on underlying mechanisms of PGRs biosynthesis under stressed conditions and their potential roles in imparting tolerance against adverse effects of suboptimal growth conditions.
Unique Pharmacological Properties of α-Conotoxin OmIA at α7 nAChRs

OmIA, isolated from Conus omaria venom, is a potent antagonist at α7 nAChRs. We determined the co-crystal structure of OmIA with Lymnae stagnalis acetylcholine binding protein (Ls-AChBP) that identified His5, Val10 and Asn11 as key determinants for the high potency of OmIA at α7 nAChRs. Remarkably, despite a competitive binding mode observed in the co-crystal structure, OmIA and analogues displayed functional insurmountable antagonism at α7 and α3β4 nAChRs, except OmIA analogues having long side chain at position 10 ([V10Q]OmIA and [V10L]OmIA), which were partial insurmountable antagonist at α7 nAChRs in the presence of type II positive allosteric modulators (PAMs). A “two-state, two-step” model was used to explain these observations, with [V10Q]OmIA and [V10L]OmIA co-existing in a fast reversible/surmountable as well as a tight binding/insurmountable state. OmIA and analogues also showed biphasic-inhibition at α7 nAChRs in the presence of PNU120596, with a preference for the high-affinity binding site following prolonged exposure. The molecular basis of binding and complex pharmacological profile of OmIA at α7 nAChRs presented in here expands on the potential of α-conotoxins to probe the pharmacological properties of nAChRs and may help guide the development novel α7 modulators.