Miracle-dz/UniFAR-FTUs huggingface dataset:
Lingual bone thickness in the apical region of the horizontal mandibular third molar: A cross-sectional study in young Japanese

Background Perforation of the lingual plate in the apical region of mandibular third molars will increase the risk of aberration and migration of the root tip and the risk of lingual nerve injury. The aim of this study was to analyze anatomical information, including relationships between the apical region of horizontally impacted mandibular third molars and lingual plates, in young Japanese. Methods Japanese patients, with horizontally impacted third molars, who underwent CT examination as a preoperative assessment for mandibular third molar extraction were included, and anatomical characteristics in the apical region of the right mandibular third molar were analyzed, in this study. Results A total of 121 patients were included based on the inclusion and exclusion criteria of this study. The mean and standard deviation of the bone thickness on the lingual side of the mandibular third molar in the apical region was 1.5 ± 1.6 mm, and the absence of lingual cortical bone in the apical region, namely, “perforation”, was observed in 44 patients. The statistical analysis revealed the predictors of cases with perforation as follows: gender, age, and the available space evaluated by Pell and Gregory classification. Conclusions This study clarified that “perforation” was sometimes observed in young Japanese, and that the predictors of those cases were as follows: gender, age, and the available space evaluated by Pell and Gregory classification.
Crowned dens syndrome—case of crystal deposition in cervical spine

ABSTRACT Neck pain can be very bothersome for patients, and most will seek analgesic relief as soon as possible. We present a case of crystal deposition in the cervical spine where a frail patient admitted for pneumonia developed severe neck pain raising suspicion of discitis, and did not respond to standard analgesic medications. Investigations revealed crystal deposition around the dens and alar ligaments (C1 and C2 Spine) suggestive of crowned dens syndrome, which responded promptly to steroid therapy and averting the patient from invasive investigations and intense treatment with antibiotics.
FAM3B Serves as a Biomarker for the Development and Malignancy of Oral Lichen Planus

Purpose Oral lichen planus (OLP) is a potentially malignant condition with unclear etiology. This study aimed to identify potential biomarkers and mechanisms for OLP progression through bioinformatics analyses. Methods Gene Expression Omnibus (GEO) datasets were screened to identify differentially expressed genes (DEGs) between OLP patients and healthy individuals. The functions and enriched pathways of the DEGs were identified. Sequencing dataset GSE70665 was then used to analyze the role of DEGs in the development of OLP to oral squamous cell carcinoma (OSCC). Oncomine and The Cancer Genome Atlas (TCGA) databases were utilized to evaluate clinicopathological characters of OSCC. Univariate and multivariate Cox regression models were used to identify independent prognostic factors. Results A total of 24 DEGs were identified between OLP and normal samples. FAM3B was under-expressed in OLP compared with normal samples and was further significantly downregulated in OSCC compared with OLP. Under-expression of FAM3B was significantly correlated with tumor stage and disease-specific survival (DSS), progression-free interval (PFI) and overall survival (OS) of OSCC patients. With univariate and multivariate Cox regression analysis, FAM3B was an independent prognostic factor. Conclusion Under-expression of FAM3B was associated with the development and malignancy of OLP. FAM3B may serve as a potential prognostic biomarker for OLP.
The complete chloroplast genome of Prunus tangutica (Batal.) Korsh

Abstract The complete cp genome of Prunus tangutica is 158,131 bp in length, exhibits a typical quadripartite structural organization, consisting of a large single copy (LSC) region of 86,266 bp, two inverted repeats (IR) regions of 26,389 bp, and a small single copy (SSC) region of 19,087 bp. The cp genome contains 131 complete genes, including 86 protein-coding genes (86 PCGs), 8 ribosomal RNA genes (8 rRNAs), and 37 tRNA genes (37 tRNAs). Most genes occur in a single copy, while 19 genes occur in double, including 4 rRNAs (4.5S, 5S, 16S, and 23S rRNA), 7 tRNAs (trnA-UGC, trnI-GAU, trnL-CAA, trnI-CAU, trnN-GUU, trnR-ACG, and trnV-GAC), and 5 PCGs (rps7, ndhB, ycf2, rpl2 and rpl23). The overall GC content of cp DNA is 36.7%, the corresponding values of the LSC, SSC, and IR regions are 34.6%, 30.1%, and 42.6%, respectively. Further, the phylogenetic analysis suggested that the P. tangutica was closely related to Prunus tenella. The results of P. tangutica will lay a foundation for further research.
Less Well-Known Consequences of the Long-Term Use of Opioid Analgesics: A Comprehensive Literature Review

Background The adverse effects of short-term opioid analgesics are well known and acknowledged; however, the spectrum of the sequelae of long-term use seems less clear. Some effects may remain undetected but still have the potential to cause harm and reduce patients’ quality of life. Objective To review the literature on the adverse effects of long-term opioid therapy. Methods We performed a quasi-systematic search, analyzing articles published in the MEDLINE database between January 2000 and March 2021 that identified adverse effects of opioids used for chronic pain treatment. Results Growing evidence indicates that there are multiple serious adverse effects of opioid treatment. Long-term opioid use may have significant effects on the endocrine, immune, cardiovascular, respiratory, gastrointestinal, and neural systems. Studies show that long-term opioid treatment increases the risk of fractures, infections, cardiovascular complications, sleep-disordered breathing, bowel dysfunction, overdose, and mortality. Opioids may potentially affect cancer development. Most consequences of the long-term use of opioids have been identified in studies of patients with non-malignant pain. Conclusion Studies indicate that long-term use of opioids increases the risk of drug-related events in a significant number of patients. Clinicians should be aware of these complications associated with prescribing opioids, discuss them with patients, prevent complications, if possible, and diagnose them early and manage adequately. More human studies are needed to assess the risk, including trials with individual opioids, because they have different adverse effect profiles.
Eye Size Affects Cuteness in Different Facial Expressions and Ages

Researchers have suggested that infants exhibiting baby schema are considered cute. These similar studies have mainly focused on changes in overall baby schema facial features. However, whether a change in only eye size affects the perception of cuteness across different facial expressions and ages has not been explicitly evaluated until now. In the present study, a paired comparison method and 7-point scale were used to investigate the effects of eye size on perceived cuteness across facial expressions (positive, neutral, and negative) and ages (adults and infants). The results show that stimuli with large eyes were perceived to be cuter than both unmanipulated eyes and small eyes across all facial expressions and age groups. This suggests not only that the effect of baby schema on cuteness is based on changes in a set of features but also that eye size as an individual feature can affect the perception of cuteness.
Comparative metabolomics analysis of milk components between Italian Mediterranean buffaloes and Chinese Holstein cows based on LC-MS/MS technology

Buffalo and cow milk have a very different composition in terms of fat, protein, and total solids. For a better knowledge of such a difference, the milk metabolic profiles and characteristics of metabolites was investigated in Italian Mediterranean buffaloes and Chinese Holstein cows were investigated by liquid chromatography tandem-mass spectrometry (LC-MS/MS) in this study. Totally, 23 differential metabolites were identified to be significantly different in the milk from the two species of which 15 were up-regulated and 8 down-regulated in Italian Mediterranean buffaloes. Metabolic pathway analysis revealed that 4 metabolites (choline, acetylcholine, nicotinamide and uric acid) were significantly enriched in glycerophospholipid metabolism, nicotinate and nicotinamide metabolism, glycine, serine and threonine metabolism, as well as purine metabolism. The results provided further insights for a deep understanding of the potential metabolic mechanisms responsible for the different performance of Italian Mediterranean buffaloes’ and Chinese Holstein cows’ milk. The findings will offer new tools for the improvement and novel directions for the development of dairy industry.
Clinical Manifestations and Genetic Analysis of 5 Korean Choroideremia Patients Initially Diagnosed With Retinitis Pigmentosa

Background To investigate the clinical findings of choroideremia patients and perform genetic analysis by whole-exome sequencing (WES). Methods A total of 94 patients initially diagnosed with retinitis pigmentosa (RP) at another hospital, and who visited our hospital for genetic analysis by WES, were included in the study, along with 64 family members. All subjects underwent comprehensive ophthalmic evaluation, including best-corrected visual acuity, slit lamp examination, fundus photography, fundus autofluorescence (FAF), fluorescein angiography (FAG), visual field (VF), electroretinogram (ERG), and optical coherence tomography (OCT). Results In six male patients with suspected choroideremia, extensive retinal pigment epithelium (RPE) and severe loss of choroid were observed in the fundus, but not in the macula. CHM gene mutation was confirmed in five patients. A novel single nucleotide variant at a splice site was observed in one patient. OCT showed marked thinning of the outernuclear layer and choroid, except in the macula. FAF showed a small area of hyperfluorescence in the posterior pole. In addition, characteristic interlaminar bridges were observed in four patients. On FAG, hypofluorescence was seen up to the far-peripheral retina in five patients. Conclusion Of the 94 patients initially diagnosed with RP, CHM mutation was identified in five (5.3%) by WES. Choroideremia should be considered as a differential diagnosis of RP. WES would be useful for identifying the causes of hereditary retinal disease.
Multidimensional assessment of anxiety through the State-Trait Inventory for Cognitive and Somatic Anxiety (STICSA): From dimensionality to response prediction across emotional contexts

The assessment of mal-adaptive anxiety is crucial, considering the associated personal, economic, and societal burden. The State-Trait Inventory for Cognitive and Somatic Anxiety (STICSA) is a self-report instrument developed to provide multidimensional anxiety assessment in four dimensions: trait-cognitive, trait-somatic, state-cognitive and state-somatic. This research aimed to extend STICSA’s psychometric studies through the assessment of its dimensionality, reliability, measurement invariance and nomological validity in the Portuguese population. Additionally, the predictive validity of STICSA-Trait was also evaluated, through the analysis of the relationship between self-reported trait anxiety and both the subjective and the psychophysiological response across distinct emotional situations. Similarly to previous studies, results supported both a four-factor and two separated bi-factor structures. Measurement invariance across sex groups was also supported, and good nomological validity was observed. Moreover, STICSA trait-cognitive dimension was associated with differences in self-reported arousal between groups of high/low anxiety, whereas STICSA trait-somatic dimension was related to differences in both the subjective and psychophysiological response. Together, these results support STICSA as a useful instrument for a broader anxiety assessment, crucial for an informed diagnosis and practice.
Supplementing cultured human myotubes with hibernating bear serum results in increased protein content by modulating Akt/FOXO3a signaling

Hibernating bears remain in their dens for 5–7 months during winter and survive without eating or drinking while staying inactive. However, they maintain their physical functions with minimal skeletal muscle atrophy and metabolic dysfunction. In bears, resistance to skeletal muscle atrophy during hibernation is likely mediated by seasonally altered systemic factors that are independent of neuromuscular activity. To determine whether there are components in bear serum that regulate protein and energy metabolism, differentiated human skeletal muscle cells were treated with bear serum (5% in DMEM/Ham’s F-12, 24 h) collected during active summer (July) and hibernating winter (February) periods. The serum samples were collected from the same individual bears (Ursus thibetanus japonicus, n = 7 in each season). Total protein content in cultured skeletal muscle cells was significantly increased following a 24 h treatment with hibernating bear serum. Although the protein synthesis rate was not altered, the expression of MuRF1 protein, a muscle-specific E3 ubiquitin ligase was significantly decreased along with a concomitant activation of Akt/FOXO3a signaling. Increased levels of insulin-like growth factor-1 (IGF-1) were also observed in hibernating bear serum. These observations suggest that protein metabolism in cultured human myotubes may be altered when incubated with hibernating bear serum, with a significant increase in serum IGF-1 and diminished MuRF1 expression, a potential target of Akt/FOXO3a signaling. A protein sparing phenotype in cultured muscle cells by treatment with hibernating bear serum holds potential for the development of methods to prevent human muscle atrophy and related disorders.
Generating symmetry-protected long-range entanglement

Entanglement between spatially distant qubits is perhaps the most counterintuitive and vital resource for distributed quantum computing. However, despite a few special cases, there is no known general procedure to maximally entangle two distant parts of an interacting many-body system. Here we present a symmetry-based approach, whereby one applies several timed pulses to drive a system to a particular symmetry sector with maximal bipartite long-range entanglement. As a concrete example, we demonstrate how a simple sequence of on-site pulses on a qubit array can efficiently produce any given number of stable nonlocal Bell pairs, realizable in several present-day atomic and photonic experimental platforms. More generally, our approach paves a route for novel state preparation by harnessing symmetry. For instance, we show how it enables the creation of long-sought-after superconducting $\eta$ pairs in a repulsive Hubbard model.
Metropolitan Optical Networks: A Survey on New Architectures and Future Trends

Metropolitan optical networks are undergoing major transformations to continue being able to provide services that meet the requirements of the applications of the future. The arrival of the $5G$ will expand the possibilities for offering IoT applications, autonomous vehicles, and smart cities services while imposing strong pressure on the physical infrastructure currently implemented, as well as on static traffic engineering techniques that do not respond in an agile way to the dynamic and heterogeneous nature of the upcoming traffic patterns. In order to guarantee the strictest quality of service and quality of experience requirements for users, as well as meeting the providers' objectives of maintaining an acceptable trade-off between cost and performance, new architectures for metropolitan optical networks have been proposed in the literature, with a growing interest starting from $2017$. However, due to the proliferation of a dozen of new architectures in recent years, many questions need to be investigated regarding the planning, implementation, and management of these architectures, before they could be considered for practical application. This work presents a comprehensive survey of the new proposed architectures for metropolitan optical networks. Firstly, the main data transmission systems, equipment involved, and the structural organization of the new metro ecosystems are discussed. The already established and the novel architectures are presented, highlighting its characteristics and application, and comparative analysis among these architectures is carried out identifying the future technological trends. Finally, outstanding research questions are drawn to help direct future research on the field.
From an Authentication Question to a Public Social Event: Characterizing Birthday Sharing on Twitter

Date of birth (DOB) has historically been considered as private information and safe to use for authentication, but recent years have seen a shift towards wide public sharing. In this work we characterize how modern social media users are approaching the sharing of birthday wishes publicly online. Over 45 days, we collected over 2.8M tweets wishing happy birthday to 724K Twitter accounts. For 50K accounts, their age was likely mentioned revealing their DOB, and 10% were protected accounts. Our findings show that the majority of both public and protected accounts seem to be accepting of their birthdays and DOB being revealed online by their friends even when they do not have it listed on their profiles. We further complemented our findings through a survey to measure awareness of DOB disclosure issues and how people think about sharing different types of birthday-related information. Our analysis shows that giving birthday wishes to others online is considered a celebration and many users are quite comfortable with it. This view matches the trend also seen in security where the use of DOB in authentication process is no longer considered best practice.
Two-dimensional Airy waves and three-wave solitons in quadratic media

We address the dynamics of two-dimensional (2D) truncated Airy waves (TAWs) and three-component solitons in the system of two fundamental-frequency (FF) and second-harmonic (SH) fields, coupled by quadratic ( χ(2) ) terms. The system models second–harmonic-generating optical media and atomic-molecular mixtures in Bose–Einstein condensates. In addition to stable solitons, the system maintains truncated-Airy-waves states in either one of the FF components, represented by exact solutions, which are stable, unlike the Airy waves in the degenerate (two-component) χ(2) system. It is also possible to imprint vorticity onto the 2D Airy modes. By means of systematic simulations, we examine interactions between TAWs originally carried by different FF components, which are bending in opposite directions, through the SH field. The interaction leads to fusion of the input into a pair of narrow solitons. This is opposed to what happens in the 1D system, where the interacting Aity waves split into a large number of solitons. The interaction of truncated Aity waves carrying identical imprinted vorticities creates an additional pair of solitons, while opposite vorticities create a set of small-amplitude ‘debris’ in the output. Slowly moving solitons colliding with a heavy TAW bounce back, faster ones are absorbed by it, and collisions are quasi-elastic for fast solitons. Soliton-soliton collisions lead to merger into a single mode, or elastic passage, for lower and higher velocities, respectively.
A new quasi-one-dimensional superconductor parent compound NaMn$_6$Bi$_5$ with lower antiferromagnetic transition temperatures

Mn-based superconductor is rare and recently reported in quasi-onedimensional KMn6Bi5 with [Mn6Bi5]columns under high pressure. Here we report the synthesis, magnetic properties, electrical resistivity, and specific heat capacity of the newly-discovered quasi-one-dimensional NaMn6Bi5 single crystal. Compared with other AMn6Bi5 (A = K, Rb, and Cs), NaMn6Bi5 has larger intra-column Bi-Bi bond length, which may result in the two decoupled antiferromagnetic transitions at 47.3 K and 52.3 K. The relatively lower antiferromagnetic transition temperatures make NaMn6Bi5 a more suitable platform to explore Mn-based superconductors. Anisotropic resistivity and nonFermi liquid behavior at low temperature are observed. Heat capacity measurement reveals that NaMn6Bi5 has similar Debye temperature with those of AMn6Bi5 (A = K and Rb), whereas the Sommerfeld coefficient is unusually large. Using first-principles calculations, the quite different density of states and an unusual enhancement near the Fermi level are observed for NaMn6Bi5, when compared with those of other AMn6Bi5 (A = K, Rb, and Cs) compounds.
Moiré Landau levels of a 
C4
-symmetric twisted bilayer system in the absence of a magnetic field

It is widely known that the twisted bilayer graphene (TBG) shows ﬂat bands at magic angles, which can be well described by the eﬀective continuum model derived by Bistritzer and MacDonald (BM). We propose in this paper a similar twisted bilayer system but deﬁned on the square lattice with π -ﬂux per plaquette, and study its spectrum using the BM Hamiltonian with a mass term which is originated from the staggered potential. The basic diﬀerence between the TBG and the present model is simply rotational symmetry, C 3 vs C 4 , as well as a mass term. Nevertheless, the feature of the ﬂat bands is quite diﬀerent: Those of the TBG appear at magic angles only, while the present model shows many ﬂat bands, which are reminiscent of Landau levels, quite stably at any angles even in the absence of a magnetic ﬁeld other than π -ﬂux which keeps time reversal (TR) symmetry. Moreover, ﬂat bands emerge in the mass gap of the Dirac spectrum, and each state composing these ﬂat bands is well-localized at the position forming the moir´e lattice. It turns out that the moir´e potential serves as a periodic magnetic ﬁeld, which can give energies smaller that the gap around moir´e lattice positions. We derive a local Hamiltonian valid around the moir´e lattice sites and show that it indeed reproduces the energies of the ﬂat bands within the mass gap. Since these mid-gap states are localized at the moir´e lattice, they form degenerate levels, which may be referred to as moir´e Landau levels, although the mechanism of degeneracies are diﬀerent from the conventional Landau levels. Interestingly, doubled fermions of the BH Hamiltonian associated with two layers have opposite charges when they couple with the eﬀective moir´e magnetic ﬁled, which concern TR symmetry. This is a generic feature of the C 4 symmetric moir´e system described by the BM Hamiltonian.