Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of N-Acetylcysteine at high doses as an oral treatment for patients hospitalized with COVID-19

Infection by SARS-CoV-2 causing coronavirus disease 2019 (COVID-19) can be associated with serious and life-threatening conditions, including acute respiratory distress syndrome (ARDS). Severity and mortality have been related to a cytokine storm, an imbalance of oxidative stress, and a pro-thrombotic state. We conducted an observational retrospective cohort study from a community-based large population of hospitalized COVID-19 PCR + patients admitted from March 01, 2020, to January 24, 2021, with integrated primary to tertiary care information in Castilla la Mancha, Spain. We explored the potential benefits of the antioxidant, anti-inflammatory and anti-thrombotic drug N-acetylcysteine (NAC) administered orally in high doses (600 mg every 8 h), added to standard of care in COVID-19 patients by using the free text information contained in their electronic health records (EHRs). Out of 19,208 patients with a diagnosis of COVID-19 hospitalized, we studied 2071 (10.8%) users of oral NAC at high doses. COVID-19 patients treated with NAC were older, predominantly male, and with more comorbidities such as hypertension, dyslipidemia, diabetes, and COPD when compared with those not on NAC (all p < 0.05). Despite greater baseline risk, use of NAC in COVID-19 patients was associated with significantly lower mortality (OR 0.56; 95%CI 0.47–0.67), a finding that remained significant in a multivariate analysis adjusting by baseline characteristics and concomitant use of corticosteroids. There were no significant differences with the use of NAC on the mean duration of hospitalization, admission to the intensive care unit or use of invasive mechanical ventilation. The observed association signaling to better relevant outcomes in COVID-19 patients treated with NAC at high doses should be further explored in other settings and populations and in randomized controlled trials.
How cognitive and emotional empathy relate to rational thinking: empirical evidence and meta-analysis

ABSTRACT Empathy is frequently described in opposition to rationality. Yet in two studies, we demonstrate that the relationship between rationality and empathy is nuanced and likely context dependent. Study 1 reports correlational data from two American samples and Study 2 presents a meta-analysis of existing literature (k = 22). We demonstrate that various types of cognitive empathy (perspective-taking, emotion recognition, and fantasy) are positively correlated with self-reported rationality, but unrelated to rational performance. In contrast, types of emotional empathy (empathic concern, personal distress, and emotion contagion) are generally negatively correlated with performance measures of rationality, but their relationships with self-reported rationality are divergent. Although these results do not settle the debate on empathy and rationality, they challenge the opposing domains hypothesis and provide tentative support for a dual-process model of empathy. Overall, these results indicate that the relationship between rationality and empathy differs depending upon how rationality and empathy are measured.
Comprando Rico y Sano: Increasing Latino Nutrition Knowledge, Healthful Diets, and Food Access Through a National Community-Based Intervention

Purpose Evaluation findings from Comprando Rico y Sano (CRS), a culturally relevant, community-based intervention addressing nutrition knowledge and food access are presented. Design No-control quasi-experimental intervention with pre, post, and follow-up assessments. Setting CRS was promotores-led through UnidosUS's Affiliate Network of community–based partners. Sample Low-income Latino adults (N = 966) receiving services at 25 partner sites. Intervention CRS was a six-hour intervention focused on nutrition knowledge and consumption of fruits, vegetables, and home-prepared meals. It also provided guidance for health-conscious grocery shopping, Supplemental Nutrition Assistance Program (SNAP) information, and enrollment assistance. Measures Self-report surveys assessed nutrition knowledge; intention to change; and frequency of fruit, vegetable, and home-prepared meal consumption. Sites reported monthly SNAP enrollment data. Analysis Paired-samples t-tests and repeated-measures ANOVAs assessed changes in knowledge, intentions, and behavior from pre-to-post (n = 960) and pre-to-follow-up (n = 115). Results Pre-to-follow-up increases in nutrition knowledge (P < .001) were observed. Intention to consume more vegetables (P = .027) and home-prepared meals (P < .001) also improved between pre- and follow-up. Increases from pre-to-follow-up were observed for frequency of consuming fruits (P = .007), vegetables (P = .001), and home-prepared meals (P < .001). Across 16 months, 24,359 Latinos enrolled for SNAP. Conclusion Large-scale community collaborations to deliver culturally relevant nutrition education and SNAP enrollment assistance can increase food access, health literacy, and promote healthful diets for Latinos.
Hypertension and contraceptive use among women of child-bearing age in the United States from 2001 to 2018

Background: Hypertension (HTN) in pregnancy is a leading cause of maternal mortality in the United States. Contraception is widely used, and estrogen-based combined hormonal forms are known to increase blood pressure (BP). With nearly half of pregnancies unplanned and many antihypertensive medications teratogenic, appropriate contraception is critical in child-bearing age women with HTN. Methods: Using the National Health and Nutrition Examination Surveys (NHANES) from 2001 to 2018, we evaluated contraception and antihypertensive medication use in women of child-bearing age (20–50 years). Women who had undergone sterilization or menopause were excluded. HTN was defined based on a self-reported provider diagnosis and BP ≥130/80 mm Hg or antihypertensive medication use. Contraception included non-barrier methods (pills/patch/ring, injections, long-acting reversible contraceptives) or consistent condom use. Multivariable logistic regression was used to model the odds of contraception use. Temporal trends in contraception use were reported. Results: Of the 8726 women, 12.4% had HTN with mean age (standard error) 36.0 (0.3) years. In women with HTN, 9.2% used non-barrier contraception and 10.4% used condoms only. Over half (52.7%) of women with HTN on antihypertensive medications were taking medications contraindicated in pregnancy, with no difference seen by contraceptive status. In logistic regression models, contraceptive use was lower in the older-aged women. In women with HTN on non-barrier contraception, combined hormonal contraceptive use declined, from 100% (2001–2006) to 81.4% (2013–2018, P < 0.001). Conclusions: Many women with self-reported HTN are not using adequate contraception. Of the small proportion on non-barrier contraceptives, the majority are using estrogen-based, BP-raising methods.
Inequities in Child Protective Services Contact Between Black and White Children

Child protective services (CPS) contact occurs at substantially higher rates among Black than White families. The present study considers systemic racism as a central driver of this disparity and emphasizes racialized poverty as a possible mechanism. We used data from the Fragile Families and Child Wellbeing Study and logistic regression analyses to assess the associations between income poverty, a racialized experience, and CPS contact, separately among Black and White families. Results indicated that income poverty was a significant predictor of CPS contact among White families, who were protected by higher income. In contrast, income per se was not a significant predictor of CPS contact among Black families, who were instead impacted by racialized family regulation and consequences of poverty, such as poor health and depression. Refundable state Earned Income Tax Credit (EITC) policies were protective for Black families, and more expansive Temporary Assistance for Needy Families (TANF) programs decreased CPS contact for Black and White families. Implications include centering systemic racism and specifically racialized poverty as causes of racial inequities in CPS contact and rethinking the role of CPS in protecting children.
Exposure In Vivo as a Treatment Approach to Target Pain-Related Fear: Theory and New Insights from Research and Cinical Practice.

Pain-related fear (PRF) can be a significant factor contributing to the development and maintenance of pain-related disability in individuals with persistent pain. One treatment approach to target PRF and related avoidance-behavior is exposure in vivo (EXP). EXP has a long history in the field of anxiety, a field that is constantly evolving. This Perspective outlines recent theoretical advancements and how they apply to EXP for PRF, including suggestions for how to optimize inhibitory learning during EXP; reviews mechanistic work from neuroimaging supporting the targeting of PRF in people with chronic pain; and focuses on clinical applications of EXP for PRF, as EXP is moving into new directions regarding who is receiving EXP (eg, EXP in chronic secondary pain) and how treatment is provided (EXP in primary care with a crucial role for physical therapists). Considerations are provided regarding challenges, remaining questions, and promising future perspectives.
Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis

Limb regeneration is a frontier in biomedical science. Identifying triggers of innate morphogenetic responses in vivo to induce the growth of healthy patterned tissue would address the needs of millions of patients, from diabetics to victims of trauma. Organisms such as Xenopus laevis—whose limited regenerative capacities in adulthood mirror those of humans—are important models with which to test interventions that can restore form and function. Here, we demonstrate long-term (18 months) regrowth, marked tissue repatterning, and functional restoration of an amputated X. laevis hindlimb following a 24-hour exposure to a multidrug, pro-regenerative treatment delivered by a wearable bioreactor. Regenerated tissues composed of skin, bone, vasculature, and nerves significantly exceeded the complexity and sensorimotor capacities of untreated and control animals’ hypomorphic spikes. RNA sequencing of early tissue buds revealed activation of developmental pathways such as Wnt/β-catenin, TGF-β, hedgehog, and Notch. These data demonstrate the successful “kickstarting” of endogenous regenerative pathways in a vertebrate model.
Practical Applications for Designing Soccer’ Training Tasks From Multivariate Data Analysis: A Systematic Review Emphasizing Tactical Training

Novel viewpoints have led to an understanding that good soccer performers are capable of continuous decision-making and performing excellent motor skills in a well-conditioned mental state. Our aims in this review were to (a) summarize the effects of different conditions and constraints on a soccer player’s response and (b) identify potential training designs for varied soccer tasks from a multivariate perspective, emphasizing tactical training. We performed a systematic literature review according to PRISMA guidelines and identified multiple different player constraints, including model strategies for play, drills designed for varied conditions, and training regimens for the dimensions of the physical demands soccer players will face. The use of match-sized training spaces may improve physical fitness and collective tactical behavior, while smaller spaces may contribute to improving tactical behavior from micro-structures (e.g., 1 vs. 1). Pre-session exercises that accelerate the appearance of fatigue during training may help delay the onset of match fatigue and boost players’ creativity. Pitch modifications (dimensions or boundary modifications), modification of game principles (defending strategies or team formations), and altering the number of players involved or coach instructions may contribute to different player improvements. Differential learning, as a non-linear pedagogy, may induce improvements in all dimensions, but especially in creative thinking.
Relating self‐disorders to neurocognitive and psychopathological measures in first‐episode schizophrenia

The notion of a disturbed self as the core feature of schizophrenia dates back to the founding texts on the illness. Since the development of the psychometric tool for examination of anomalous self‐experience (EASE), self‐disorders have become accessible to empirical research. Empirical studies have shown that EASE measured self‐disorders predict schizophrenia spectrum in prospective studies and consistently show a selective hyper aggregation of self‐disorder in schizophrenia and schizotypal disorders. The aim of this study is to investigate the relationship between self‐disorders cognitive deficits and symptoms in schizophrenia.
Scope of add on repetitive transcranial magnetic stimulation in treating depression in Parkinson’s disease

Parkinson ’ s disease is a common neurological disorder in the elderly population with a prevalence of 1%; however, in the general population, its prevalence is 0.1% to 0.2%. 1 It is a neurodegenerative disease commonly affecting the dopaminergic neurons of the nigrostriatal pathway; however, as the disease progresses, pathological changes occur in other cortical regions. 1 Though it is classically thought to be a motor disorder, the manifestation of Parkinson ’ s disease is diverse
Mutations in exon region of BRCA1‐related RING domain 1 gene and risk of breast cancer

BRCA1‐associated RING Domain 1 (BARD1) is an important gene related to breast cancer development. However, the role of BARD1 mutations in breast cancer remains inconclusive. This study is to investigate the relationship between exon mutations of BARD1 gene and the risk of early‐onset breast cancer.
Influence of metatarsophalangeal joint stiffness on take-off performances and lower-limb biomechanics in jump manoeuvres

ABSTRACT Forefoot and toes are prominent regions for locomotion and individual metatarsophalangeal joint (MTPJ) stiffness may be linked to jump take-off mechanics and performances. However, little is known about the relationships between MTPJ stiffness and take-off related variables. This study examined the relationship between individual MTPJ stiffness and biomechanical variables under various vertical countermovement jumps (CMJ) conditions. We measured MTPJ stiffness on 21 male university basketball players and then asked them to perform jumps under single, consecutive and running CMJ conditions. Pearson’s correlation coefficient was employed to examine the relationships between MTP passive stiffness and each jumping performance, ground reaction force (GRF) and joint kinematic and kinetic variables. The results indicated that MTPJ stiffness significantly correlated with maximum jump height (r = 0.49, moderate), peak take-off velocity (r = 0.47, moderate), peak take-off ankle plantarflexion moment (r = 0.68, strong), peak dorsiflexion moment (r = 0.60, strong) and peak take-off ankle power (r = 0.44, moderate) in consecutive CMJ. Only a moderate correlation between MTPJ stiffness and peak MTPJ extension take-off velocity (r = −0.46, moderate) was determined in a single CMJ. There were no significant correlations found in running CMJ conditions. These findings imply that higher MTPJ stiffness of participants was related to improved jump performances in consecutive jumps.
Hyper-expression and hypomethylation of TM4SF1 are associated with lymph node metastases in papillary thyroid carcinoma patients.

Lymph node metastases (LNM) are an indicator for recurrence in papillary thyroid carcinoma (PTC) patients. However, prophylactic neck dissection (ND) cannot improve survival or recurrence rate because of increased surgical complications and occult lymph node metastases. Biomarkers are needed for the prediction of high-risk of LNM to avoid unnecessary operation and reduce the missed malignant lymph nodules. GEO database was searched for the differentially expressed genes (DEGs) between PTC patients with LNM (N1) and those without LNM (N0), transcriptional and methylation data of DEGs in THCA were examined from databases. The expression and methylation of TM4SF1 in fresh and paraffin tissues of PTC patients were examined by qRT-PCR, IHC, and MSP. TM4SF1 was the only one significantly associated with LNM. UALCAN revealed that TM4SF1 was overexpressed and hypomethylated in LNM patients. MEXPRESS presented a negative correlation between gene expression and promoter methylation of TM4SF1. DEGs were enriched in multiple pathways and the Extracellular Matrix (ECM)-receptor interaction pathway showed the greatest correlation with LNM. IHC and qRT-PCR of tissues demonstrated that the expression of TM4SF1 in the N1 group was 4.5-fold higher than that in the N0 group (p < 0.05). MSP exhibited that the positive rate of aberrant promoter methylation of TM4SF1 was 8.38% in N1 and 66.7% in N0 group (p < 0.05). Hyper-expression and hypomethylation of TM4SF1 are associated with lymph node metastases in PTC patients.
Survival and Prognostic Factors in Patients with Aggressive Cutaneous T-cell Lymphomas

Aggressive primary cutaneous T-cell lymphomas include advanced-stage mycosis fungoides (stage ≥ IIB mycosis fungoides), Sézary syndrome, gamma/delta cutaneous lymphoma, nasal type lymphoma, aggressive epidermotropic CD8+ T-cell lymphoma and some cutaneous lymphomas not otherwise specified. To evaluate their long-term prognosis, we conducted a retrospective cohort study of 85 patients diagnosed between 2005 and 2020 with advanced-stage mycosis fungoides (n = 48), Sézary syndrome (n = 28) or aggressive non-mycosis fungoides/Sézary syndrome subtypes (n = 9). The median survival times in these 3 groups were 118.7, 45.7 and 11.2 months, respectively, and the 5-year survival rates were 55.3%, 27.8% and 33.3%, respectively. Multivariate analyses in patients with mycosis fungoides/Sézary syndrome identified age ≥ 70 years, Eastern Cooperative Oncology Group Performance Status ≥ 2, and the high-risk group according to the Cutaneous Lymphoma International Consortium prognostic model, as adverse prognostic factors. Seven patients in this mycosis fungoides/Sézary syndrome group were in complete long-term remission after treatment with bexarotene, including 4 patients living without any treatment for 16–101 months.
68Ga-DOTA-FAPI-04 Uptake of Accessory Breast in a Patient With Breast Cancer.

ABSTRACT 68Ga-DOTA-FAPI-04 is a promising PET agent for tumor imaging. However, some nonneoplastic lesions can also show increased FAPI uptake. Herein, we presented a case of a patient with left breast cancer who showed a right accessory breast with increased tracer uptake on 68Ga-DOTA-FAPI-04 PET/CT. Final histopathology confirmed there were no malignant components in the accessory breast.
Mine Safety Monitoring and Control Technology and System

The paper had a study on the effect of the mine safety monitoring and control system in the prevention and control of the mine gas,mine fire disaster and other accidents and the accident investigations.The problems existed in the application and management of the mine safety monitoring and control system were analyzed.The technical key points of the application and management for the mine safety monitoring and control were provided.Firstly,the sensors for the methane,air velocity,ventilation pressure,ventilation tubing,ventilation door,on/off of the local fan,on/off of the main fan,feed status and others should be correctly in installation and maintenance according to the required quantity and locations.Secondly,according to the different controlled objects,the power off interlocking and the ventilation and power interlocking of the methane should be correctly connected.Thirdly,according to the different locations of the working faces,air-returning gateway and others,the alarming gas density,the power off gas density,the power reset gas density and the power off area should be correctly set up.Fourthly,each 10 days,the methane sensors shall be correctly adjusted with the standard gas sample and air sample and the methane power off interlocking and the ventilation and power interlocking functions shall be measured and tested.At last but not the least after the alarming of the methane over limit,power off,feed abnormal and ventilation stopped,the safety measures of the power off,men evacuation and others shall be on time conducted.
Early-term Optical Coherence Tomography Angiographic Findings in Pediatric Patients Infected with COVID-19

ABSTRACT Purpose The aim of this study was to investigate possible vascular changes in pediatric patients infected with COVID-19 and to compare these with an age-matched control group. Methods All patients underwent an ocular assessment and optical coherence tomography angiography examination. Two vascular networks were analyzed as the superficial and deep regions. Results Evaluation was made of 40 eyes of 20 patients who had recently recovered from COVID infection and 80 eyes of 40 healthy individuals. The DCP-VD values of the COVID group were significantly lower than the control group in most quadrants. The FAZ PERIM and FAZ area values in the COVID patients were higher than the control group, but not statistically significant (p>.05). Conclusion Pediatric cases of COVID-19 may differ from adults based on structural and immune response differences, and that OCTA can be a noninvasive guide for analysis of the end-organ effects of pediatric COVID disease.
When Laplacian Scale Mixture Meets Three-Layer Transform: A Parametric Tensor Sparsity for Tensor Completion

Recently, tensor sparsity modeling has achieved great success in the tensor completion (TC) problem. In real applications, the sparsity of a tensor can be rationally measured by low-rank tensor decomposition. However, existing methods either suffer from limited modeling power in estimating accurate rank or have difficulty in depicting hierarchical structure underlying such data ensembles. To address these issues, we propose a parametric tensor sparsity measure model, which encodes the sparsity for a general tensor by Laplacian scale mixture (LSM) modeling based on three-layer transform (TLT) for factor subspace prior with Tucker decomposition. Specifically, the sparsity of a tensor is first transformed into factor subspace, and then factor sparsity in the gradient domain is used to express the local similarity in within-mode. To further refine the sparsity, we adopt LSM by the transform learning scheme to self-adaptively depict deeper layer structured sparsity, in which the transformed sparse matrices in the sense of a statistical model can be modeled as the product of a Laplacian vector and a hidden positive scalar multiplier. We call the method as parametric tensor sparsity delivered by LSM-TLT. By a progressive transformation operator, we formulate the LSM-TLT model and use it to address the TC problem, and then the alternating direction method of multipliers-based optimization algorithm is designed to solve the problem. The experimental results on RGB images, hyperspectral images (HSIs), and videos demonstrate the proposed method outperforms state of the arts.