Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Protein-Glutaminase on Calcium Sulphate-Induced Gels of SPI with Different Thermal Treatments

The effects of protein-glutaminase (PG) on calcium sulphate (CaSO4)-induced gels of soy protein isolate (SPI) with different heat treatment levels were investigated. The time-dependent degree of deamidation showed that the mild denaturation of the protein favored the deamidation. The particle size distribution showed that the heat treatment increased the SPI particle size, and the particle size distribution of the SPI shifted to the right or increased the proportion of the large particle size component as the degree of deamidation increased for each sample. Rheological analysis showed that the deamidation substantially pushed up the gel temperature and decreased the value of G′. The gel strength and water-holding capacity showed that the higher the amount of enzyme added, the more significant the decrease in gel strength, while the gel water-holding capacity increased. In summary, the deamidation of PG and heat treatment can affect the gel properties of SPI synergistically.
Synthesis of an Environmentally Friendly Modified Mulberry Branch-Derived Biochar Composite: High Degradation Efficiency of BPA and Mitigation of Toxicity in Silkworm Larvae

In the present study, mulberry branch-derived biochar CuO (MBC/CuO) composite was successfully synthesized and used as a catalyst to activate persulfate (PS) for the degradation of bisphenol A (BPA). The MBC/CuO/PS system exhibited a high degradation efficiency (93%) of BPA, under the conditions of 0.1 g/L MBC/CuO, 1.0 mM PS, 10 mg/L BPA. Free radical quenching and electron spin-resonance spectroscopy (ESR) experiments confirmed that both free radicals •OH, SO4•− and O2•− and non-radicals 1O2 were involved in the MBC/CuO reaction system. Cl− and NOM displayed negligible influence on the degradation of BPA, while HCO3− promoted the removal of BPA. In addition, the toxicity tests of BPA, MBC/CuO and the degraded BPA solution were conducted by the 5th instar silkworm larvae. The toxicity of BPA was reduced after the treatment in the MBC/CuO/PS system, and no obvious toxicity of the synthesized MBC/CuO composite was found in the toxicity evaluation experiments. This work provides a new value-added utilization of mulberry branches as a cost-effective and environmentally friendly PS activator.
Prospective Evaluation of a Topical Botanical Skin Care Regimen on Mild to Moderate Facial and Truncal Acne and Mood

Acne vulgaris is a common inflammatory condition that can be associated with profound psychosocial impacts. Conventional treatment includes topical retinoids, benzoyl peroxide, and antimicrobials, and some may cause irritation and skin dryness. In this 8-week open-label study, we examined the effects of a botanical skin care regimen (Codex Labs Shaant Balancing regimen) on mild to moderate facial and truncal acne. Twenty-four male and female subjects between the ages of 12 and 45 years were assessed for eligibility, 20 were enrolled, and 15 completed all study visits. Facial and truncal acne lesion counts, skin hydration, sebum excretion rate, and mood were assessed at baseline, week 4, and week 8. Total facial lesion counts (inflammatory and non-inflammatory lesions) decreased by 20.5% at week 4 (p = 0.06) and by 25.2% at week 8 (p < 0.05). Inflammatory lesion counts on the trunk were found to decrease at week 8 relative to baseline by 48% (p < 0.05). Forehead sebum excretion rate decreased by 40% at week 4 (p = 0.07) and 22% at week 8 (p = 0.08), and cheek skin hydration increased by 27.6% at week 4 (p = 0.14) and 65% at week 8 (p = 0.10). Participants also experienced significant improvement in components of a positive effect, such as feeling “strong” and “inspired”, and a decrease in negative effects, such as feeling “irritable. ” Overall, the botanical skin care regimen was found to be well-tolerated. Our study suggests that a botanical skin care regimen may reduce facial and truncal acne lesion counts, increase skin hydration, reduce sebum production, and augment positive effects and moods in those with mild to moderate facial and truncal acne.
Benzimidazole Derivatives Suppress Fusarium Wilt Disease via Interaction with ERG6 of Fusarium equiseti and Activation of the Antioxidant Defense System of Pepper Plants

Sweet pepper (Capsicum annuum L.), also known as bell pepper, is one of the most widely grown vegetable crops worldwide. It is attacked by numerous phytopathogenic fungi, such as Fusarium equiseti, the causal agent of Fusarium wilt disease. In the current study, we proposed two benzimidazole derivatives, including 2-(2-hydroxyphenyl)-1-H benzimidazole (HPBI) and its aluminum complex (Al−HPBI complex), as potential control alternatives to F. equiseti. Our findings showed that both compounds demonstrated dose-dependent antifungal activity against F. equiseti in vitro and significantly suppressed disease development in pepper plants under greenhouse conditions. According to in silico analysis, the F. equiseti genome possesses a predicted Sterol 24-C-methyltransferase (FeEGR6) protein that shares a high degree of homology with EGR6 from F. oxysporum (FoEGR6). It is worth mentioning that molecular docking analysis confirmed that both compounds can interact with FeEGR6 from F. equiseti as well as FoEGR6 from F. oxysporum. Moreover, root application of HPBI and its aluminum complex significantly enhanced the enzymatic activities of guaiacol-dependent peroxidases (POX), polyphenol oxidase (PPO), and upregulated four antioxidant-related enzymes, including superoxide dismutase [Cu-Zn] (CaSOD-Cu), L-ascorbate peroxidase 1, cytosolic (CaAPX), glutathione reductase, chloroplastic (CaGR), and monodehydroascorbate reductase (CaMDHAR). Additionally, both benzimidazole derivatives induced the accumulation of total soluble phenolics and total soluble flavonoids. Collectively, these findings suggest that the application of HPBI and Al−HPBI complex induce both enzymatic and nonenzymatic antioxidant defense machinery.
Therapeutic Implications of the Drug Resistance Conferred by Extracellular Vesicles Derived from Triple-Negative Breast Cancer Cells

Anticancer drug resistance is a significant impediment in current cancer treatment. Extracellular vesicles (EVs) derived from cancer cells were recently acknowledged as a critical mechanism of drug resistance, tumor progression, and metastasis. EVs are enveloped vesicles comprising a lipid bilayer that transfers various cargo, including proteins, nucleic acids, lipids, and metabolites, from an originating cell to a recipient cell. Investigating the mechanisms whereby EVs confer drug resistance is still in the early stages. In this review, I analyze the roles of EVs derived from triple-negative breast cancer cells (TNBC-EVs) in anticancer drug resistance and discuss strategies to overcome TNBC-EV-mediated drug resistance.
Use of a Closure Device for the Management of Inadvertent Placement of a Central Venous Catheter in the Carotid Artery: A Case Report and Literature Review

The placement of a central venous catheter (CVC) is a common intervention in hospitalized patients. Several adverse events have been reported in this “blind” procedure when it is performed without the aid of ultrasound, including artery catheterization, which although uncommon, is a serious complication. Potential treatment options include manual compression, open surgical repair, and endovascular treatment. A 62-year-old critically ill patient with accidental arterial catheterization of the right common carotid artery (CCA) during placement of CVC is presented. The catheter was removed successfully with the use of a Perclose-ProGlide closure device. A systematic literature review was performed to identify similar cases treated with the same technique. This case presents an alternative minimally invasive treatment option, using a Perclose Proglide (Abbott) closure device for the removal of a misplaced CVC in the right CCA. Although this is an off-label use of the device it can be an effective alternative treatment option, especially in unstable patients.
Magnetically and electrically tunable transport property of the heterojunction composed of La0.9Ca0.1MnO3+δ and Nb-doped SrTiO3

A manganite-based heterojunction composed of an oxygen-rich La0.9Ca0.1MnO3+δ film and a SrTiO3 substrate doped by 1 wt% Nb has been fabricated, and its transport behaviours were experimentally studied. The junction resistance shows a metal-to-insulator transition at a critical temperature that varies with applied magnetic field. In contrast, bias current does not affect the transition temperature, although it depresses the junction resistance significantly. The junction resistance decreases with magnetic field, and the maximum magnetoresistance is ∼−60% under a field of 5 T, appearing at T≈220 K. The magnetoresistance gets its maximum value in the zero electric bias limit, and drops rapidly when bias voltage exceeds a threshold of 0.1–0.2 V, varying with temperature.
Fast-proton transport in hydrazine sulphate. II. NMR linewidth and relaxation studies

For pt.I see ibid., vol.16, no.16, p.3081 (1983). The proton mobility has been observed in hydrazine sulphate (H2H6SO4) from NMR studies. The linewidth has been measured as a function of temperature. It shows a sudden line narrowing at 150K indicating that the H+ are mobile at temperatures higher than this. Further, a minor hump in the linewidth curve is obtained at 228K which indicates a structural change. The relaxation time measurement (T1 and T2) also confirms the above conclusion. From the linewidth data at different temperatures, the jump attempt frequency is estimated to be about 1011 s-1. The low attempt frequency of about 1011 s-1 is nearly the proton tunnelling frequency suggesting H+ motion.
Experience with the mTOR Inhibitor Everolimus in Pediatric Liver Graft Recipients

Introduction: Immunosuppression after pediatric liver transplantation remains a major challenge. MTOR inhibitors provide a promising therapeutic approach in combination with reduced CNI after transplantation. However, there are still few data regarding their use in children. Patients: We analyzed 37 patients with a median age of 10 years, who received Everolimus for one or more of the following indications: I = chronic graft dysfunction (n = 22); II = progressive renal impairment (n = 5); III = non-tolerable side effects with previous immunosuppressive medication (n = 6); and IV = malignancies (n = 10). The median follow-up time was 36 months. Results: Patient survival was 97%, and graft survival 84%, respectively. Stabilization of graft function was observed in 59% in subgroup 1, with 18.2% ultimately requiring retransplantation. No patient in subgroup IV developed recurrence of his primary tumor or PTLD by the endpoint of the study. Side effects were observed in 67.5% of the study patients, with infections being the most frequent (n = 20; 54.1%). There were no relevant effects on growth and development. Conclusion: Everolimus seems to be a treatment option in selected pediatric liver graft recipients for whom other regimens are not suitable. Overall, the efficacy was good and the side effect profile appeared to be acceptable.
Therapeutic Drug Monitoring of Vancomycin Concentrations for the Management of Bone and Joint Infections: An Urgent Need

Vancomycin is used for the treatment of bone and joint infections (BJI), but scarce information is available about its pharmacokinetic/pharmacodynamic (PK/PD) characteristics. We aimed to identify the risk factors associated with the non-achievement of an optimal PK/PD target in the first therapeutic drug monitoring (TDM). Methods: A retrospective study was conducted in a tertiary hospital from January 2020 to January 2022. Patients with BJI and TDM of vancomycin on day 2 of treatment were included. Initial vancomycin fixed doses (1 g every 8 h or 12 h) was decided by the responsible doctors. According to TDM results, dosage adjustments were performed. An AUC24h/MIC < 400 mg × h/L, between 400 and 600 mg × h/L and >600 mg × h/L, were defined as suboptimal, optimal and supratherapeutic, respectively. Patients were grouped into these three categories. Demographic, clinical and PK characteristics were compared between groups. Nephrotoxicity at the end of treatment was assessed. Results: A total of 94 patients were included: 22 (23.4%), 42 (44.7%) and 30 (31.9%) presented an infratherapeutic, optimal and supratherapeutic PK/PD targets, respectively. A younger age and initial vancomycin dose <40 mg/kg/day were predictive factors for achieving a suboptimal PK/PD target, while older age, higher serum-creatinine and dose >40 mg/kg/day were associated with overexposure. The nephrotoxicity rate was 22.7%. More than 50% of patients did not achieve an optimal PK/PD. Considering age, baseline serum-creatinine and body weight, TDM is required to readily achieve an optimal and safe exposure.
Modeling Primary Atomization

This review concerns recent progress in primary atomization modeling. The numerical approaches based on direct simulation are described first. Although direct numerical simulation (DNS) offers the potential to study the physical processes during primary atomization in detail, thereby supplementing experimental diagnostics, it also introduces severe numerical challenges. We outline these challenges and the numerical methods to address them, highlighting some recent efforts in performing detailed simulation of the primary atomization process. The second part is devoted to phenomenological models of primary atomization. Because earlier conventional models of breakup are well reported in the available literature, we highlight only two recent developments: (a) stochastic simulation of the liquid jet depletion in the framework of fragmentation under scaling symmetry and (b) primary atomization in terms of Reynolds-averaged Navier-Stokes (RANS) mixing with a strong variation of density.
Augmenting Mental Health Support for Patients Accessing Different Degrees of Formal Psychiatric Care through a Supportive Text Messaging Program: Protocol for a Randomized Controlled Trial

Patients feel more vulnerable when accessing community mental health programs for the first time or after being discharged from psychiatric inpatient units. Long wait times for follow-up appointments, shortage of mental health professionals, lack of service integration, and scarcity of tailored support can weaken their connection to the health care system. As a result, patients can present low adherence, dissatisfaction with treatment, and recurrent hospitalizations. Finding solutions to avoid unnecessary high-cost services and providing tailored and cost-effective mental health interventions may reduce the health system burden and augment patient support. We propose implementing an add-on, supportive text messaging service (Text4Support), developed using cognitive–behavioural therapy (CBT) principles to augment mental health support for patients attending to or being discharged from psychiatric care in Nova Scotia, Canada. This randomized controlled trial aims to investigate the effectiveness of Text4Support in improving mental health outcomes and overall mental well-being compared with usual care. We also will examine the intervention’s impact on health services utilization and patient satisfaction. The results from this study will provide evidence on stepped and technology-based mental health care, which will contribute to generating new knowledge about mental health innovations in various clinical contexts, which is not only helpful for the local context but to other jurisdictions in Canada and abroad that are seeking to improve their health care.
Comparison of the Rostral Epidural Rete Mirabile and the Patterns of Its Blood Supply in Selected Suiformes and Hippopotamuses

Simple Summary The rostral epidural rete mirabile is built of considerable small arterial vessels that anastomose with each other at the base of the cranial cavity. This structure is formed as a result of the division of a large arterial vessel into many small arteries. Furthermore, on the other side of the rete mirabile, these small arteries are joined together to form one large artery, through which blood flows out of the rete mirabile. This system participates in decreasing the temperature of the brain and thus protects the body from thermal stress. Moreover, it influences body–water balance and has a crucial role in the retrograde transfer of neuropeptides. According to old systematics, pigs and hippopotamuses are in one suborder. Hence it was decided to compare their structures and blood supplies. It was found that the shape of the analyzed structure and the inflows differed in these groups. Abstract The rostral epidural rete mirabile (rete mirabile epidurale rostrale) is built of considerable small arterial vessels that anastomose with each other. This structure is formed as a result of the division of a large arterial vessel into many small arteries. Furthermore, on the other side of the rete mirabile, these small arteries are joined together to form one large artery, through which blood flows out of the rete mirabile. This system participates in decreasing the temperature of the brain and thus protects the body from thermal stress. Moreover, it influences body–water balance and has a crucial role in the retrograde transfer of neuropeptides. The goal of this study was to describe the rostral epidural rete mirabile and pathways that provide blood to this structure as well as compare it in selected Suiformes and hippopotamuses. The study was performed on desert warthogs (Phacochoerus aethiopicus), Eurasian wild boars (Sus scrofa), collared peccaries (Pecari tajacu), pygmy hippopotamuses (Choeropsis liberiensis), and common hippopotamuses (Hippopotamus amphibius). Preparations were made using the latex method and corrosion cast. An elongated shape characterizes its anatomy with a much wider rostral part than caudal part in the Eurasian wild boars, desert warthogs, and collared peccaries. The main source of blood was the branch to the rostral epidural rete mirabile branched off from the internal carotid artery. Moreover, blood enters the rete by the caudal branch and rostral branch to the rostral epidural rete mirabile. In hippopotamuses, the major source of blood was the rostral branches to the rostral epidural rete mirabile.
A Case Study of Private School Teachers’ Personal Practical Knowledge

This paper is a case study of the personal practical knowledge of two private middle school teachers, discussing the core teaching concepts and practices of private middle school teachers and their causes. The research shows that these two teachers have their own core concepts to guide teaching practice, and found that their personal experiences The social environment in which they live affects the formation of their core ideas to varying degrees. The article focuses on the great impact of the teaching and management mode of private schools on Teachers’ education ideas, and hopes to have more research in this regard. For a long time, private schools have been subordinates to the public education system, so the academic community has not paid enough attention to private teachers for a long time, but the impact of private school teachers on students is not weaker than that of public teachers, It should receive more attention from the academic community
A bidimensional class of optimality criteria involving φp and characteristic criteria

A new biparametric class of criteria for Optimal Experimental Design generalizing the families of φp and Characteristic Criteria is presented. Some properties of the Characteristic Criteria are provided: in particular, differentiability, monotonicity and convexity. A statistical interpretation is also offered. Optimal designs with respect to Characteristic Criteria are obtained for polynomial and compartmental models and an extension of the Michaelis-Menten model. A thorough discussion for the trigonometric model is given. The computed optimal designs are shown to be quite efficient for A-, D- and Ds -optimality. Thus, some of them appear as a natural compromise between different optimality criteria. A simulation in multiple linear regression confirms the quality of Characteristic designs for discovering significant differences between parameters.
Apple Leave Disease Detection Using Collaborative ML/DL and Artificial Intelligence Methods: Scientometric Analysis

Infection in apple leaves is typically brought on by unanticipated weather conditions such as rain, hailstorms, draughts, and fog. As a direct consequence of this, the farmers suffer a significant loss of productivity. It is essential to be able to identify apple leaf diseases in advance in order to prevent the occurrence of this disease and minimise losses to productivity caused by it. The research offers a bibliometric analysis of the effectiveness of artificial intelligence in diagnosing diseases affecting apple leaves. The study provides a bibliometric evaluation of apple leaf disease detection using artificial intelligence. Through an analysis of broad current developments, publication and citation structures, ownership and cooperation patterns, bibliographic coupling, productivity patterns, and other characteristics, this scientometric study seeks to discover apple diseases. Nevertheless, numerous exploratory, conceptual, and empirical studies have concentrated on the identification of apple illnesses. However, given that disease detection is not confined to a single field of study, there have been very few attempts to create an extensive science map of transdisciplinary studies. In bibliometric assessments, it is important to take into account the growing amount of research on this subject. The study synthesises knowledge structures to determine the trend in the research topic. A scientometric analysis was performed on a sample of 214 documents in the subject of identifying apple leaf disease using a scientific search technique on the Scopus database for the years 2011–2022. In order to conduct the study, the Bibliometrix suite’s VOSviewer and the web-based Biblioshiny software were also utilised. Important journals, authors, nations, articles, and subjects were chosen using the automated workflow of the software. Furthermore, citation and co-citation checks were performed along with social network analysis. In addition to the intellectual and social organisation of the meadow, this investigation reveals the conceptual structure of the area. It contributes to the body of literature by giving academics and practitioners a strong conceptual framework on which to base their search for solutions and by making perceptive recommendations for potential future research areas.
Consensus of multiple double‐integrator agents with intermittent measurement

This paper is concerned with consensus problems in directed networks of multiple agents with double‐integrator dynamics. It is assumed that each agent adjusts its state based on the information of its states relative to its neighbors at discrete times and the interaction topology among agents is time‐varying. Both synchronous and asynchronous cases are considered. The synchrony means that each agent's update times, at which it obtains new control signals, are the same as the others', and the asynchrony implies that each agent's update times are independent of the others'. In the synchronous case, the consensus problem is proved to be equivalent to the asymptotic stability problem of a discrete‐time switched system. By analyzing the asymptotic stability of the discrete‐time switched system, it is shown that consensus can be reached if the update time intervals are small sufficiently, and an allowable upper bound of update time intervals is obtained. In the asynchronous case, the consensus problem is transformed into the global asymptotic stability problem of a continuous‐time switched system with time‐varying delays. In virtue of a linear matrix inequality method, it is proved that consensus can be reached if the delays are small enough, and an admissible upper bound of delays is derived. Simulations are provided to illustrate the effectiveness of the theoretical results. Copyright © 2009 John Wiley & Sons, Ltd.