Miracle-dz/UniFAR-FTUs huggingface dataset:
A mechanistic approach to tactile friction

To a large extent, the functionality and comfort experienced during the use of everyday products, such as apparel, household appliances and sports equipment, are determined by the frictional behaviour of contact that occurs with the skin. For product engineers who aim to control and optimize the sensorial properties of a product surface interacting with the skin, it is essential to understand this frictional behaviour. This involves the study of local friction behaviour at the scale of the surface roughness. In this work a mechanistic approach was adopted in which analytical models from contact mechanics theory were used to develop a model which describes the tactile friction behaviour against the human fingerpad as a function of asperity geometry and operational conditions.
Boost-Based MPPT for the MTM PCDU of the BepiColombo Mission

BepiColombo is an ESA mission to Mercury to be launched in 2013. A better knowledge of the origin and evolution of the planet, of its structure and vestigial atmosphere, of its magnetosphere, and of the origin of its magnetic field are the main objectives for the program. The journey to Mercury will last for approximately 6 years, and will be based on the gravity of the Earth, Venus and Mercury, and on the use of Solar Electric Propulsion. For the last, the use of the MPPT concept is essential for the mission. A mission power demand of up to 14kW is foreseen in the cruise phase for the Mercury Transfer Module (MTM) PCDU, being the power subsystem based on a 100V bus. Under this scenario, the use of a classical step-down regulator for the implementation of the MPPT power cell would require to keep the worst case minimum solar array voltage over the bus for any mission operating condition. Then, the maximum solar array voltage would become as high as to overpass the insulating capability of the isolation layer between the solar array cells and the substrate, under the high temperature environment experienced by the spacecraft near Mercury. As a result, the development of a step-up MPPT Array Power Regulator (APR) becomes a critical issue for the mission feasibility. Moreover, due to the hard environment that the solar array will be exposed to, the segregation of the solar array power is a very desirable feature. Furthermore, apart from the two classical operating modes of the APR – conductance or MPPT, depending on the spacecraft user loads demand and the available solar array power – the APR will have to operate in S3R mode for solar array voltages over the bus, with a fully autonomous transition between the three operating modes. This paper covers all the aspects related with the design of the APR MPPT concept and its implementation: APR power cell topology, control scheme, control strategy, protections. The implications on the design of the MTM PCDU MEA will be also addressed. Finally, they will be presented the results of the test carried out over an 1/10 scaled-down engineering model of the BepiColombo PCU - including 3 APRs - in front of the real operating conditions foreseen for the MTM PCDU, including all the relevant issues related to the behaviour of the Electric Propulsion load like beam-out events and load transients.
BENEFITS AND DESIGN/LOCATION CRITERIA FOR PASSING LANES

The objectives of this study are to demonstrate the feasibility and potential effectiveness of using passing lanes in Missouri, to evaluate the level of service and safety effects of existing passing lanes in Missouri, to establish criteria for determining where passing lanes could improve level of service and safety on Missouri highways, and to develop recommendations for the design, signing, and marking of passing lanes for potential application in Missouri. This report addresses the traffic operational and safety effectiveness of passing lanes as well as the geometric design and effective signing and marking of passing lanes. An evaluation of three existing passing lane sites on Missouri National Highway System (NHS) routes found that those passing lanes improve percent time spent following on those roads by 10 to 31% in comparison to a conventional two-lane highway without passing lanes. A safety evaluation found that the accident frequency per mi per year within passing lane sections on two-lane highways is 12 to 24% lower than for conventional two-lane highway sections. Criteria to determine where passing lanes could provide level of service and safety benefits on Missouri highways are presented. Case studies of locations on five Missouri NHS routes examined the potential traffic operational and safety effectiveness of alternative passing lane configurations.
Palm (A): The Debate on Licensing Palm's OS (1997)

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State-of-the-Art of Hand Exoskeleton Systems

This paper deals with the analysis of the state-of-the-art of robotic hand exoskeletons (updated at May 2011), which is intended as the first step of a designing activity. A large number of hand exoskeletons (both products and prototypes) that feature some common characteristics and many special peculiarities are reported in the literature. Indeed, in spite of very similar functionalities, different hand exoskeletons can be extremely different for the characteristics of their mechanism architectures, control systems and working principles. The aim of this paper is to provide the reader with a complete and schematic picture of the state-of-the-art of hand exoskeletons. The focus is placed on the description of the main aspects that are involved in the exoskeleton design such as the system kinematics, the actuator systems, the transmission parts and the control schemes. Additionally, the critical issues provided by the literature analysis are discussed in order to enlighten the differences and the common features of different practical solutions. This paper may help to understand both the reasons why certain solutions are proposed for the different applications and the advantages and drawbacks of the different designs proposed in the literature. The motivation of this study is the need to design a new hand exoskeleton for rehabilitation purposes.
Aberrant angiogenesis in brain tissue in experimental Alzheimer’s disease

The aim was to study the molecular mechanisms of the violation of the structural and functional integrity of the blood-brain barrier in chronic neurodegeneration of the Alzheimer’s type associated with the development of cerebral angiopathy. Materials and methods. The transgenic model of Alzheimer’s disease is the B6SLJ-Tg line mice (APPSwFlLon, PSEN1*M146L*L286V) 6799Vas group which includes 9 months aged males. The control group included C57BL/6xSJL mice, males aged 9 months. Results. The total length of the vessels in the area of the dentate gyrus is 2.5 times greater in transgenic animal models of Alzheimer’s disease than in animals of the control group ( p < 0.01). The average diameter of blood vessels in all areas of the hippocampus is smaller compared with the control ( p < 0.05). Transgenic modeling of neurodegeneration in the CA2 zone of the hippocampus increases the relative area of tissue with increased permeability of blood-brain barrier (BBB) (17.80 [9.15; 36.75]) compared to control (1.38 [0.04; 7.60]) at p < 0.05. A similar difference ( p < 0.05) is also observed in the hippocampal area CA1. A tendency ( p > 0.05) to decrease the number of CD31+ endothelial cells in the dentate gyrus of the hippocampus (21.52 [17.56; 24.50]) in animals of the experimental group compared with the control group (23.08[21.18; 29.84]) was detected. A similar situation is observed in the CA2 and CA3 areas of the hippocampus. Conclusion. Neurodegenerative changes in the hippocampus of animals with a transgenic AD model are associated with impaired microcirculation in the brain tissue as a result of a reduction in the diameter and branching of blood vessels, and damage and increased permeability of BBB.
Epigenetically Reprogrammed Methylation as a Gifted Potential Cancer Biomarker

Ontrary to genetic changes of DNA molecule which change exactly the sequence of DNA and are not reversible, the DNA methylation involves in addition of a methyl group to cytosine nucleotide to control genes expression which is reversible [1,2]. Methylation is unique change that consequence in different gene expression pattern and finally may trigger the onset of diseases like cancer [3]. Epigenetic reprogramming in cancer cells represents a unique methylation landscape concerning the net loss of global DNA methylation simultaneously with an increase in the levels of in CpGs islands. So, cancer epigenetically reprogrammed methylation landscape (i.e., Methylscape) can be a common feature exhibited by most cancer types and therefore can be a universal cancer biomarker. The DNA methylation in molecular level change the gene expression pattern of the cell but methylation can change the physicochemical properties of DNA polymer in solution including DNA structure and its affinity as well.
Uncorrected Proof ) Title : Lentiviral mediated expression of soluble Neuropilin 1 inhibits Semaphorin 3 A-mediated Collapse Activity in vitro Running title : sNRP 1 effects on growth cone collapse

Background: Semaphorin 3A (Sema 3A) is a secreted protein, which plays an important part in the development of the nervous system. It has collapse activity on the growth cone of dorsal root ganglia. After the development of the nervous system, Sema 3A expression decreases. Neuropilin 1 is a membrane receptor of Sema 3A. When semaphorin binds to neuropilin 1, the recruitment of oligodendrocyte precursor cell to the demyelinated site decreases. In Multiple Sclerosis (MS), Sema 3A expression increases and inhibits
Proposing and developing the definition and conceptual framework for healthcare resilience to cope with disasters

Building healthcare resilience is an important step towards creating more resilient communities to better cope with future disasters. To date, however, there appears to be little literature on how the concept of healthcare resilience should be defined and operationalized with a conceptual framework. This article aims to build a comprehensive healthcare disaster management approach guided by the concept of resilience. Methods: Google and major health electronic databases were searched to retrieve critical relevant publications. A total of 61 related publications were included, to provide a comprehensive overview of theories and definitions relevant to disaster resilience. Results and Discussions: Resilience is an inherent and adaptive capacity to cope with future uncertainty, through multiple strategies with all hazards approaches, in an attempt to achieve a positive outcome with linkage and cooperation. Healthcare resilience can be defined as the capability of healthcare organisations to resist, absorb, and respond to the shock of disasters while maintaining the most essential functions, then recover to their original state or adapt to a new state. It can be assessed by criteria, namely: robustness, redundancy, resourcefulness; and a complex of key dimensions, namely: vulnerability and safety, disaster resources and preparedness, continuity of essential health services, recovery and adaptation. Conclusions: This new concept places healthcare organisations’ disaster capabilities, management tasks, activities and disaster outcomes together into a comprehensive whole view, using an integrated approach and establishing achievable goals.
IN-VIVO REPLICATION OF CYPRINID HERPESVIRUS-3 IN GOLDFISH

Cyprinid herpes virus-3 (CyHV-3) is the causative agent of the lethal, highly contagious and notifiable koi herpesvirus disease (KHVD) in common carp and koi. Since its first identification, outbreaks of KHVD have occurred worldwide with significant economic losses in common carp and ornamental koi aquaculture industries. In the present study, experimental infection of goldfish by immersion rout was established. Apparently healthy common carp and goldfish were exposed to various concentrations of the CyHV-3 and monitored for mortality and development of clinical signs. CyHV-3 DNA was detected in the tissues of the challenged goldfish and common carp, which confirm the suitability of the immersion route to be used for infection of goldfish with CyHV-3. In addition, CyHV-3 terminase gene was amplified from the RNA extracted from the goldfish gill tissues at twoand eight-days post exposure to CyHV-3. The primer set used for amplification of this gene is specific for RT-PCR and did not amplify this gene from DNA. Results of this investigation confirm the replication of CyHV-3 in the goldfish tissues, which act as a true carrier not a vector or fomites and establish the experimental infection of goldfish with CyHV-3 by immersion route.
Catching up With Aristotle

Este libro es un intento de rehabilitación de la psicología general, i.e., de una teoría comprensiva y sistemática de la psique humana. El autor, Niels Engelsted, se propone rehabilitar la psicología general recurriendo, por un lado, a la filosofía de Aristóteles y, por el otro, a la historia de la psicología. ¿Por qué recurrir a la filosofía de Aristóteles para rehabilitar la psicología general? Según Engelsted, por más que muchos de los contenidos de la psicología aristotélica hayan sido falseados, se encuentra más adelantada que la psicología contemporánea desde la perspectiva de su “alcance y su intención”. La taxonomía que Aristóteles propone en sus tratados sobre la naturaleza es una “psicología general que traza la arquitectura del dominio psicológico desde las funciones animales más básicas hasta los rasgos propiamente humanos” (p. 10). La concepción aristotélica de la naturaleza, aunque no es evolutiva, supone una continuidad entre todos los seres vivos y exige una explicación sistemática de todas las funciones atribuidas al alma. Según Engelsted, en la aproximación aristotélica a la psicología está la solución a la crisis de la psicología: sólo hay que “ponerse al día con Aristóteles”, como reza el título del libro.
Supervising Projects You Don't Understand - Do Your Major Projects Receive the Leadership They Need?

This study addresses the dilemmas and challenges facing senior executives who serve on steering committees or other supervising bodies of large and strategically important initiatives. They ultimately bear responsibility, but they are not in a position that allows them to understand all the details of what is going on. They do not have the time, they are distant from the actual work processes, and, after all, executives cannot be experts on everything. These initiatives are often cross-functional, involve breaking new ground, and bring together areas outside of executives’ normal expertise. Furthermore, since this these initiatives are temporary, normally in the form of a project, executives cannot rely on learning over time or draw upon established corporate practices. In this situation, how can executives provide the guidance and supervision these initiatives need? How can they avoid abdicating responsibility and becoming spectators to a project run by experts? The management profession has a solid understanding of what project managers and their teams should do. But we do not well understand the challenge for the steering committee that supervises the project managers. The added difficulty comes from organizational distance: hidden information, multiple areas of expertise, non-aligned interests, and other changing circumstances. Some projects fail not because of project management itself, but because of failure of the supervisors to provide the necessary senior leadership and governance to the project. Thus, project supervision has a very important effect on project success. But supervising a temporary, one-off strategic initiative that enters new territory is very different from managing an ongoing business. When the setting is temporary, and separate from your regular executive role, how deeply should you delve into the project? How do you set targets, evaluate progress, align the initiative with the organization, and evaluate the people? Based on interviews with 17 senior managers in three countries (Sweden, Germany and France), plus five investor-board members of start-ups in Shanghai, we make recommendations to senior managers on the composition of a good steering committee and how it should conduct itself. We find that the two dominant challenges of large projects are uncertainty as well as goal agreement among stakeholders. We discover strategies for shaping the steering committee, understanding the project, setting targets and measuring progress, getting the right information from the project, responding to surprises (which always happen in large projects), and for motivating and evaluating the people.
LESSONS LEARNT AFTER IMPLEMENTATION OF COMMUNITY-LED-TO-TOTAL SANITATION INTERVENTION IN BUSIA COUNTY KENYA

In December 2012, Kenya government and UNICEF jointly implemented a Community-Led-Total Sanitation Intervention (CLTSI) in Busia County to tame poor sanitation that was at 42% vs 49% National. The CLTSI was to achieve total sanitation among Busia County households through sanitation behavior change. Main aim of the study was to document the lessons learnt after implementation of CLTSI in Busia County. The study focused on the implementation process of the CLTSI to draw experiences. Documenting lessons learnt helped in understanding and improving implementation of CLTSI, accounting for success (or failure) and enhancing best practice of CLTSI management before countrywide rollout. Quasi experimental design was used while multi-stage and random sampling was used to sample respondents. A total of 35 (70%) of primary implementers of CLTSI participated in the study Structured questionnaire was used to collect the data. Findings show that out of 35 facilitators who implemented CLTSI, only 25(71.4%) were trained on the rigours of CLTSI. Duration of training varied from 3 days 10 (28.6%) to 5 days 15 (42.9%) of which more than a half 21(60.0%) CLTSI facilitators felt training was inadequate. Challenges experienced during implementation of CLTSI included: time constraint 24 (68.6%), transport constraint 20(57.1%), inadequate skills 17(48.6%), poor community mobilization 35(100.0%), household illiteracy 29 (82.9%), financial constraint 18 (51.9%). Other reasons included hostile community, poor leadership 32 (91.4%). For the purposes of rolling up the CLTSI, some lessons learnt could be adopted in order to achieve total sanitation in the country. From our evaluation study, CLTSI was found to have impacted positively to the residents of Busia County.
Menarche and menopausal age changes over  40 years and its effective factors in women studied in Cohart Fasa population

Background: Age at menarche and menopause is affected by various factors. A reduction has been observed in these ages over time. The present study aimed to determine the trend of changes in age at menarche and age at menopause among the women participating in Fasa Cohort Study over a 40-year period. Methods: This cross-sectional, descriptive-analytical study was conducted on 5545 women aged over 35 years in Fasa cohort population as a branch of the Persian cohort study. The participants were selected via census. The study data were obtained from the information registered in Fasa Cohort Center. Then, they were entered into the SPSS 22 software and were analyzed using descriptive statistics, chi-square test, correlation coefficient, and linear regression analysis. Results: The results showed that the mean age at menarche reduced from 14.66 to 13.40 years and the mean age at menopause decreased from 56.88 to 40.16 years over the 40-year period, and the reductions were statistically significant (p<0.001). Age at menarche was affected by body mass index and physical activity. Besides, age at menopause was affected by education level, marital status, diabetes, hypertension, cardiovascular diseases, cervical cancer, hysterectomy, and stillbirth (p<0.001). Conclusion: The results showed a decrease in age at menarche and age at menopause over the 40-year period.
Technology towards a SAW based phononic crystal sensor

Phononic crystals (PnC) with a specifically designed defect have been recently introduced as novel sensor platform. Those sensors feature a band gap covering the typical input span of the measurand as well as a narrow transmission peak within the band gap where the frequency of maximum transmission is governed by the measurand. This innovative approach has been applied for determination of compounds in liquids [1]. Improvement of sensitivity requires higher probing frequencies around 100 MHz and above. In this range surface acoustic wave devices (SAW) provide a promising basis for PnC based microsensors [2]. The respective feature size of the PnC SAW sensor has dimensions in the range of 100 μm and below. Whereas those dimensions are state of the art for common MEMS materials, etching of holes and cavities in piezoelectric materials having an aspect ratio diameter/depth is challenging. In this contribution we describe an improved technological process to manufacture considerably deep and uniform phononic crystal structures inside of SAW substrates.
Effects of Multi-Exercise Prescription on Elderly Patients with Mild Cognitive Impairment

According to active aging proposed by the World Health Organization, participation (the creation of social participation channels), health (the establishment of an environment for physical and mental health), and security (social and economic security and life safety), as well as the comprehensive health promotion concept based on a fitness perspective that was developed by the American College of Sports Medicine (ACSM, 2016). With the increasing number of older adults and life expectancy, the issue of aging population has become more critical, leading to the growing prominence of problems related to elderly health care and treatment (Huang, & Wang, 2018; Erickson, Weinstein , Lopez, 2012; Wilson , Jackson , Sapey , Lord, 2017). In addition, globally, the prevalence of dementia has been growing rapidly in recent years. These types of well-being complement each other and affect lifestyle and health quality in older adults.
Computer Security: Virus Highlights Need for Improved Internet Management

Abstract : In November 1988, a computer program caused thousands of computers on the Internet a multinetwork system connecting over 60,000 computers nationwide and overseas to shut down. This program, commonly referred to as a computer virus or worm, entered computers and continuously recopied itself, consuming resources and hampering network operations. Concerned about Internet security and the virus incident, the Chairman, Subcommittee on Telecommunications and Finance, House Committee on Energy and Commerce, asked GAO to provide an overview of the virus incident, examine issues relating to Internet security and vulnerabilities, and describe the factors affecting the prosecution of computer virus incidents.