Miracle-dz/UniFAR-FTUs huggingface dataset:
Efﬁcacy of Daptomycin-Cloxacillin Combination in Experimental Foreign-Body Infection Due to Methicillin-Resistant Staphylococcus

Despite the use of daptomycin alone at high doses (greater than 6 mg/kg of body weight/day) against difﬁcult-to-treat infections, clinical failures and resistance appeared. Recently, the combination daptomycin-cloxacillin showed enhanced efﬁcacy in clearing bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA). The aim of this study was to evaluate the efﬁcacy of daptomycin at usual and high doses (equivalent to 6 and 10 mg/kg/day in humans, respectively) in combination with cloxacillin in a rat tissue cage infection model by MRSA and to compare its efﬁcacy to that of daptomycin-rifampin. We used MRSA strain ATCC BAA-39. In the log- and stationary-phase kill curves, daptomycin-cloxacillin improved the bactericidal activity of daptomycin, especially in log phase. For in vivo studies, therapy was administered intraperitoneally for 7 days with daptomycin at 100 mg/kg/day and 45/mg/kg/day (daptomycin 100 and daptomycin 45), daptomycin 100-cloxacillin at 200 mg/kg/12 h, daptomycin 45-cloxacillin, and daptomycin 100-rifampin at 25 mg/kg/12 h. Daptomycin-rifampin was the best therapy ( P < 0.05). Daptomycin 45 was the least effective treatment and
Testicular Torsion in Adolescent: A Dilemma in Early Diagnosis Lead to Infarction of Testis

Testicular torsion is an acute emergency condition that warrants urgent diagnosis to save the testis from fatal infarction. We herein report a case of Testicular infarction due to testicular torsion in a 15 years old young boy. The purpose of presenting this case is to emphasize the early intervention of Color Doppler study of scrotum to avoid delayed surgical corrective measures which, if taken on time, could have saved the testis. We strongly recommend that Testis must be examined by the consulting physician in all patients presenting with nausea, vomiting and abdominal pain and if found tender, the immediate ultrasonography of the scrotum with color doppler imaging should be done. It should also be included in the differential diagnosis of the any lower abdomen pain on either side irrespective of absence of testicular tenderness or any local complaints.
Jab1/Csn5 Signaling in Breast Cancer Jab1/Csn5 Signaling in Breast Cancer

c-Jun activation domain-binding protein1 (Jab1), also known as a monomer or the fifth component of the constitutive photomorphogenesis 9 signalosome (Csn5) complex, regulates cell proliferation, cell-cycle progression, and apoptosis and affects a series of pathways. Jab1/Csn5 also promotes cell transformation and tumorigenesis, and its overexpression in many tumor types suggests it is involved in cancer progression and closely associated with poor cancer prognosis. Jab1/Csn5 dysregulation contributes to oncogenesis by deactivating several tumor suppressors. Increasing evidence of the role of Jab1/Csn5 overexpression in breast and other cancers has spurred interest in Jab1/ Csn5 inhibitors for cancer therapy. In this chapter, we summarize the evidence demonstrating the importance of Jab1/Csn5 expression in breast and other cancers and review recent advances in dissecting the Jab1/Csn5 signaling pathway along with its potential as a therapeutic target for cancer.
F IRM S IZE AND D IVERSIFICATION : A SYMMETRIC M ULTIPRODUCT F IRMS UNDER C OURNOT C OMPETITION

A positive relationship between firm size and product diversification is a long-standing stylized fact. However, so far there is no appropriate theoretical model to explain the underlying forces of this observation. This paper analyzes an oligopoly model with asymmetric multiproduct frms, which is capable of addressing this issue. The model suggests that intangible assets of firms, which affect marginal costs or perceived quality of goods within a firm’s product line, play a key role for the empirical regularity that larger firms are more diversified.
University of Birmingham Hybrid societies

Hybrid societies are self-organizing, collective systems, which are composed of different components, for example, natural and artificial parts (bio-hybrid) or human beings inter-acting with and through technical systems (socio-technical). Many different disciplines investigate methods and systems closely related to the design of hybrid societies. A stronger collaboration between these disciplines could allow for re-use of methods and create significant synergies. We identify three main areas of challenges in the design of self-organizing hybrid societies. First, we identify the formalization challenge. There is an urgent need for a generic model that allows a description and comparison of collective hybrid societies. Second, we identify the system design challenge. Starting from the formal specification of the system, we need to develop an integrated design process. Third, we identify the challenge of interdisciplinarity. Current research on self-organizing hybrid societies stretches over many different fields and hence requires the re-use and synthesis of methods at intersections between disciplines. We then conclude by presenting our perspective for future approaches with high potential in this area.
METHODS OF AUTOMATED ALLOCATION OF CATCHMENT BASINS ACCORDING TO DIGITAL ELEVATION MODELS (ON THE EXAMPLE OF SKOLIV DISTRICT OF LVIV REGION)

in the region of 6, their area is 7 km 2 , medium-mountain 360, area 755 km 2 , high-mountain 224, area 645 km 2 . Pools are classified according to the average slope: the first category from 0–3 degrees, very gentle slopes – pools 27, area 7 km 2 ; the second category from 9–12 degrees, sloping slopes-pools of 128, the area 303 km 2 ; the third category from 12–15> degrees, steep slopes – pools of 225, the area 648 km 2 . The accuracy between the reference and the original relief model was evaluated. We can say that sle = 0.63 m slope, sle = 5.43 m height. Scientific novelty and practical significance. The technological scheme of automated separation of catchment basins according to digital relief models for Skoliv district of lviv region is proposed and the method of separation of catchment basins is worked out. According to the developed method, maps of watercourses of different orders and their catchment basins and classification of basins by area on the territory of Skole administrative district, which can be used by local organizations on water resources, are constructed.
Traditional Knowledge on Mushroom consumption habits of Amhara region in four selected districts; Mecha,

Population growth coupled with increase in demand for food, domestication and scientific cultivation of wild edible mushroom is alternatives means to alleviate food shortage and malnutrition.The purpose of this study was to assess traditional wild mushroom consumption habit infour selected districts of Amhara region, Mecha, Zege, Fogera and Bahir Dar Zuria. In this study 115 adult individuals 81 males & 34 females were selected and used as information source. Data were collected using structured open and close ended questionnaire, interview as well as personal observation. The study result indicated that (90.43%) of the Mecha, Zege and Bahirdar Zuria Woreda residents have awareness about wild mushroom consumption and its various benefits.About 9.57% of the residents do not have an awareness especially Fogeradistrict. Wild mushroom collection was donemainly from cultivated farmland (65.21%) followed by termite nests (14.78%), uncultivated land (13.04%), forestvicinity (5.21%). All family members, children, women and men were involved in mushroom collection. However, none of the inhabitants was found to cultivate mushrooms artificially in scientific ways due to various reasons, 63.48% respondents said lack of awareness on artificial mushroom cultivationmethod. 33.04% respondent said non-availability of the well-known mushroom species, 3.47% respondeddue to religion pressure. All the inhabitants have stated the status of wild mushroom distribution has been sharply decreasing from time to time since the past two decades. They mentioned the cause of reduction are climate change (49%), urbanization (13.51%), chemical pollution (12.57%), over overgrazing (9.57%), unknown reason (13.91%) followed by deforestation (8.79 %%) reported by the respondents. From the current study, it is concluded that the majority of inhabitants like eating wild mushrooms traditionally and well aware about the current decrease in wild edible mushrooms distribution, they have neither cultivated nor are aware about the possibility of cultivating mushroom artificially, implying that there is an urgent need to initiate and create awareness among the inhabitants to adopt cultivation and conservation of such very important non-timber forest product in order to protect the decreasing status of the wild mushroom. As well as to decrease the lake Tana basin ecosystem destruction, Furthermore, such awareness and cultivation process could also be important to use the mushrooms for serving to diversify agricultural activity and supplement diet as well as income generation in the long run for the local farming community. It is requiring to domesticating wild edible mushroom through exploration and conservation of this bio resource fungi of the country at national fungal culture collection center.
Small G Proteins in Islet (cid:1) -Cell Function

Glucose-stimulated insulin secretion from the islet (cid:1) -cell involves a sequence of metabolic events and an in-terplaybetweenawiderangeofsignalingpathwaysleadingtothegenerationofsecondmessengers( e . g .,cyclic nucleotides, adenine and guanine nucleotides, soluble lipid messengers) and mobilization of calcium ions. Consequent to the generation of necessary signals, the insulin-laden secretory granules are transported from distal sites to the plasma membrane for fusion and release of their cargo into the circulation. The secretory granule transport underlies precise changes in cytoskeletal architecture involving a well-coordinated cross-talk betweenvarioussignalingproteins,includingsmallmolecularmassGTP-bindingproteins(Gproteins)andtheir respective effector proteins. The purpose of this article is to provide an overview of current understanding of the identity of small G proteins ( e . g ., Cdc42, Rac1, and ARF-6) and their corresponding regulatory factors ( e . g ., GDP/GTP-exchange factors, GDP-dissociation inhibitors) in the pancreatic (cid:1) -cell. Plausible mechanisms underlying regulation of these signaling proteins by insulin secretagogues are also discussed. In addition to their positive modulatory roles, certain small G proteins also contribute to the metabolic dysfunction and demise of the islet (cid:1) -cell seen in in vitro and in vivo models of impaired insulin secretion and diabetes. Emerging evidence also suggests significant insulin secretory abnormalities in small G protein knockout animals, further empha-sizingvitalrolesfortheseproteinsinnormalhealthandfunctionoftheislet (cid:1) -cell.Potentialsignificanceofthese experimental observations from multiple laboratories and possible avenues for future research in this area of islet research are highlighted. ( Endocrine Reviews 31: 52–78, 2010)
Food for Thought Size-based theory for ﬁsheries advice

Fisheries science and management is founded upon the Beverton–Holt theory of ﬁsh stock demography. The theory uses age as the structuring variable; however, there are several reasons to use body size as the structuring variable. Most of the processes that affect a ﬁsh are deter-mined by its body size rather than its age: consumption, mortality, maturation, fecundity, ﬁsh gear selectivity, etc., and measurements of body size are easy, accurate, and abundant. Here, I review size-based theory of a ﬁsh stock and compare it to classic age-based theory. I show that size- and age-based demography are equivalent representations of demography. However, size-based theory is axiomatic, which leads to a deeper theory with two advantages: predictions need fewer parameters than age-based theory and the theory connects directly to life-history traits. The connection with traits makes size-based theory particularly useful for data-poor application and facilitates evolutionary calculations. I compare age- and size-based theories for ﬁsheries impact and stock assessments and provide a perspective on the challenges and future of single-stock theory.
I N S EARCH OF I NFLATION R ATE C OMPATIBLE WITH G ROWTH T ARGET IN CEMAC C OUNTRIES

A BSTRACT : Inflation produces adverse effects to growth in economies. However, economic analysis faces a problem of determining the threshold at which inflation becomes harmful to the economy. In this article we try to determine the inflation rate favorable to growth or not for the CEMAC countries and to make contributions to economic policy.
ON E-FRAMES IN SEPARABLE HILBERT SPACES

The purpose of this paper is to introduce the concept of E − frames for a separable Hilbert space H , where E is an invertible inﬁnite matrix mapping on the Hilbert space ∞ ⊕ n =1 H . We investigate and study some properties of E − frames and characterize all E − frames for H . Further more, we characterize all dual E − frames associated with a given E − frame. A similar characterization is also established for E − orthonormal bases, E − Riesz bases and dual E − Riesz bases. In continue we obtain a lower estimate for the lower bound of some matrix operators on the p − bounded variation sequence space bv p and Euler weighted sequence space e θw,p . Then we deal with several types of E − frames such as ∆ − frames and Euler frames for H which are related to the Hilbert spaces bv 2 and e θ 2 , respectively.
Detection of Ranking Fraud and Avoidance Frauds in Mobile Applications

As we as a whole know each individual on the planet are portable users in certainty advanced mobile phone users with android applications [1]. In this way, Due to this prominence and surely understood idea there will be a quick development in mobile innovation we have seen. And in addition in information mining idea mining the required information from a specific application is extremely troublesome and vital errand. Blending these two ideas of rank fakes in android market and mining required information is gone exceptionally extreme for us and this is testing circumstance. We are utilizing this idea in entire paper. As we realize that the portable Apps has developed at tremendous speed in a few years; with respect to walk 2017, there are adjacent 2.8 million Apps at Google play and 2.2 Apps at Apple Apps store. Furthermore, there are more than 400,000 free application engineers all battling for the consideration of similar potential users [2]. The Apple App Store saw 128,000 new business applications alone in 2014 and the mobile gaming classification alone has rivalry to the tune of very nearly 300,000 applications. Here the fundamental need to influence fraud to look in Apps is via looking through the high positioned applications up to 30-40 which might be positioned high in some days or the applications which are in those high positioned records ought to be confirmed however this isn't connected when we work for a large number of uses included every day. In this way, we go for expansive view by applying some strategy to each application to judge its rank. In this paper of our task revelation of rank fraud for mobile applications, we build up a need to make a faultless, extortion less and result that shows revised application appropriately give rank; where we really get it going via seeking fraud of uses. They make fraud of App by positioned high the App by techniques utilizing, for example, human water armed forces and bot ranches; where they make extortion by downloading application through different gadgets and give counterfeit appraisals and audits. Along these lines, as we said above here we have to mine urgent information relating specific application, for example, audit which we said remarks and furthermore such huge numbers of other data we have to mine and place calculation to recognize phoniness in application rank [3].
Magnetic Fields of Black Holes and the Variability Plane

We estimated the magnetic field strength at the horizon radius of black holes, that is derived by the magnetic coupling process and depended on the black hole mass $M_{BH}$ and the accretion rate $\dot{M}$. Our estimation is based on the use of the fundamental variability plane for stellar mass black holes, AGNs and QSOs. The typical values of magnetic field strength on the black hole horizon are appeared at the level of $B_{BH}\sim 10^8$G for stellar mass black holes and $B_{BH}\sim 10^4$G for the supermassive black holes. We have obtained the relation $p_l\sim \nu^{-1/2}_b$ between the intrinsic polarization of the accretion disk radiation and the characteristic frequency of the black hole X-ray variability.
Upper Critical Magnetic Fields in Quasi-One-Dimensional Layered Superconductors

12 CHAPTER 1 Description of Quasi-One-Dimensional Layered Superconductors Within The Framework of Phenomenological Ginzburg-Landau Theory . 13 1.1 The Critical Fields of Type-II Superconductors . 13 1.2 The Phenomenological Ginzburg-Landau Theory . 15 1.3 Angular Dependence of the Upper Critical Field in the Effective Mass Model . 21 CHAPTER 2 Microscopic Description of Superconductivity: BCS theory and its Generalizations to Unconventional Superconductors . 25 2.1 Isotropic Superconductors with Singlet Pairing . 25 2.2 Unconventional Pairing: Spin-Triplet Superconductivity . 31 2.3 Paramagnetic Susceptibility and Spin-Splitting Effects in a Magnetic Field . 38 CHAPTER 3 Low-Temperature Angular Dependence of the Upper Critical Magnetic Field in Quasi-One-Dimensional Superconductors . 40 3.
COMMUNICATION AND PUBLIC OPINION PLUS C x A CHANGE?

Three central themes that have persisted throughout the history of research on communication and public opinion are examined in light of past, present, and future research. These themes include (1) ongoing concerns surrounding the political diversity of the communication environment; (2) selective exposure to political communication; and (3) the interrelationship between mass and interpersonal political communication. We explore the importance of these themes with an emphasis on how technological changes have made them, if anything, more relevant today than they were when ﬁrst identiﬁed as central concerns of the discipline. To say that communication technology has changed dramatically since the last Public Opinion Quarterly anniversary issue in 1987 is to state the obvious. But technological change alone does not necessarily dictate changes in the locus of scholarly concern. In this article, we suggest that many of the same themes that Elihu Katz identiﬁed on the 50th anniversary of Public Opinion Quarterly — which were themselves drawn from the earliest studies of communication and public opinion in the 1940s and 1950s — are as relevant today as ever. In this article, we review three major themes that connect studies of communication and public opinion from the past to those in the present and likely future. First, activity reﬂects political of the democratic ideas? the research largely a what state the communication like Beyond diversity, themes follow directly from earliest empirical
Epigenetic Modiﬁcations in Essential Hypertension

: Essential hypertension (EH) is a complex, polygenic condition with no single causative agent. Despite advances in our understanding of the pathophysiology of EH, hypertension remains one of the world’s leading public health problems. Furthermore, there is increasing evidence that epigenetic modiﬁcations are as important as genetic predisposition in the development of EH. Indeed, a complex and interactive genetic and environmental system exists to determine an individual’s risk of EH. Epigenetics refers to all heritable changes to the regulation of gene expression as well as chromatin remodelling, without involvement of nucleotide sequence changes. Epigenetic modiﬁcation is recognized as an essential process in biology, but is now being investigated for its role in the development of speciﬁc pathologic conditions, including EH. Epigenetic research will provide insights into the pathogenesis of blood pressure regulation that cannot be explained by classic Mendelian inheritance. This review concentrates on epigenetic modiﬁcations to DNA structure, including the inﬂuence of non-coding RNAs on hypertension development.
Theoretical methods for spintronics in semiconductors with applications

Theoretical studies of the role of structural inversion symmetry (SIA) and bulk inversion symmetry (BIA) in the band structure and tunneling properties of zincblende heterostructures have been carried out. The effective bond orbital model (EBOM) method is used to examine the spin splitting due to SIA in AlSb/InAs/GaSb asymmetric heterostructures. It is found for the resulting two-dimensional electron gas (2DEG) that large theoretical values of the Rashba coefficient in the range of 50E-10 eV.cm can be achieved for optimized structures. Structures presenting anticrossing of the conduction and valence bands show an appreciable reduction in the value of the Rashba coefficient. The possibility of extracting the Rashba coefficient from magnetization measurements is explored. An expression is derived, valid in the diffusive limit, for the spin polarization of the current resulting from a bias parallel to the plane of the quantum well. The EBOM method is expanded to include BIA effects. The resulting formalism is then used to compute the band structure of an AlSb/GaSb superlattice, where the BIA-induced splitting is observed. The results agree with k.p calculations. The first implementation of an 8-band Envelope Function Approximation method faithful to the T_d symmetry of bulk zincblendes has been made. It has been used to compute the bands for quantum wells with and without BIA effects included, and demonstrates that the BIA effects can be of the same order of magnitude as SIA (i.e., Rashba) effects. A 2-band Hamiltonian describing BIA effects is proposed. The origin of spurious solutions for certain values of the input parameters is determined and a condition for its absence is derived. Modest modifications to the superlattice method allow the computation of spin-dependent transmission coefficients with the multiband quantum transmitting boundary method (MQTBM). The effect of BIA on the transmitted states and the spin filtering action of an asymmetric resonant interband tunneling diode are investigated. Finally, a Monte Carlo single photon generation algorithm is devised. The photons generated are satisfactory for simulation of light emitted from band-to-band spontaneous transitions in crystals. The polarization is determined taking into account the electron spin, making the algorithm suitable for the analysis of optical detection of spin injection experiments.
Image-based Light Modification

Designers translate their ideas into images via visualization tools. Most of these tools provide some level of editing capabilities. Although these tools have very powerful and comprehensive capability in editing, they require users to have a strategy before using and decide the combination of commands he/she needs to apply. For some simple task, for instance, moving the position of the light source in an image, these tools will have very limited power (image processing) or require great amount of computational resources (render). Even though the user may have a clear idea of the expected result, current tools will have a hard time to accomplish the task, mostly because they are ‘content-blind’. To test the idea of a ‘content-aware’ image processing tool, in this research I used machine learning methods to develop a proof of concept tool that is able to rapidly relight an image based on content traits in the image (depth, shape, reflectiveness, etc.) that relate to the re-lighting task. By doing this, we can have the light weight convenience of an image processing tool as well as the content-awareness of a rendering tool.