Miracle-dz/UniFAR-FTUs huggingface dataset:
Susceptibility of Glutathione--S-Transferase Polymorphism to CVD Development in Type 2 Diabetes Mellitus - A Review.

BACKGROUND Metabolic disorder affects normal homeostasis and can lead to the development of diseases. Diabetes mellitus is the most common metabolic disorder, and a cluster of metabolic conditions can lead to cardiovascular disease (CVD) development. Diabetes mellitus and CVD are closely related, with oxidative stress, playing a major role in the pathophysiology. Glutathione-S-Transferases (GST) potentially play an important role by reducing oxidative stress and is found to be the underlying pathophysiology in the development of diabetes, cardiovascular diseases (CVD), etc. Objectives: In this review, the role of GST genetic variant in the development of diabetes mellitus, CVD and diabetic vascular complications has been focused. RESULTS Based on the literature, it is evident that the GST can act as an important biochemical tool providing significant evidence regarding oxidative stress predominant in the development of diseases. Analysis of GST gene status, particularly detection of GSTM1 and GSTT1 null mutations and GSTP1 polymorphism, have clinical importance. CONCLUSION The analysis of GST polymorphism may help identify the people at risk and provide proper medical management. Genotyping of GST gene would be a helpful biomarker for early diagnosis of CVD development in DM and also in CVD cases. More studies focusing on the association of GST polymorphism with CVD development in diabetic patients will help us determine the pathophysiology better.
Joint Learning of Feature Extraction and Clustering for Large-Scale Temporal Networks

Temporal networks are ubiquitous in nature and society, and tracking the dynamics of networks is fundamental for investigating the mechanisms of systems. Dynamic communities in temporal networks simultaneously reflect the topology of the current snapshot (clustering accuracy) and historical ones (clustering drift). Current algorithms are criticized for their inability to characterize the dynamics of networks at the vertex level, independence of feature extraction and clustering, and high time complexity. In this study, we solve these problems by proposing a novel joint learning model for dynamic community detection in temporal networks (also known as jLMDC) via joining feature extraction and clustering. This model is formulated as a constrained optimization problem. Vertices are classified into dynamic and static groups by exploring the topological structure of temporal networks to fully exploit their dynamics at each time step. Then, jLMDC updates the features of dynamic vertices by preserving features of static ones during optimization. The advantage of jLMDC is that features are extracted under the guidance of clustering, promoting performance, and saving the running time of the algorithm. Finally, we extend jLMDC to detect the overlapping dynamic community in temporal networks. The experimental results on 11 temporal networks demonstrate that jLMDC improves accuracy up to 8.23% and saves 24.89% of running time on average compared to state-of-the-art methods.
The circular RNA circ0005654 interacts with specificity protein 1 via microRNA-363 sequestration to promote gastric cancer progression

ABSTRACT Circular RNAs (circRNAs), a group of unique long noncoding RNAs, are involved in gastric carcinogenesis through multiple mechanisms, including interacting with microRNAs (miRNAs). Here, circ0005654, significantly upregulated in gastric cancer (GC), was chosen for further examination. circ0005654 was analyzed by RT-qPCR. The function of circ0005654 in GC cells was substantiated by loss-of-function assays. The mechanism of circ0005654 on miR-363/specificity protein 1 (sp1) axis was evaluated in GC cells by bioinformatics analysis, luciferase reporter, FISH, and ChIP assays. We observed that circ0005654 was enhanced in GC tissues and cells. Overexpression of circ0005654 was correlated with a poor long-term prognosis in patients with GC. Functionally, silencing of circ0005654 remarkably suppressed GC cell proliferation, migration and invasiveness in vitro and tumorigenesis and metastases in vivo. It was also established that circ0005654 served as a miR-363 sponge and enhanced sp1 expression. Furthermore, sp1 promoted GC carcinogenesis by regulating myc transcription to potentiate the Wnt/β-catenin pathway. In conclusion, circ0005654 expedites the GC development via miR-363/sp1/myc/Wnt/β-catenin axis and is a new biomarker for GC treatment regimen.
Evaluating programmed death‐ligand 1 (PD‐L1) in head and neck squamous cell carcinoma: concordance between the 22C3 PharmDx assay and the SP263 assay on whole sections from a multicentre study

The introduction of immunotherapy for patients with head and neck squamous cell carcinoma (HNSCC) raises the need for harmonisation between different types of antibody and immunohistochemistry platform for evaluating the expression of PD‐L1 by use of the combined positive score (CPS) in this tumour. The aim of this study was to compare the expression of PD‐L1 as determined with the CPS and two widely used assays (the 22C3 PharmDx assay and the SP263 assay) in a cohort of HNSCCs.
Ensuring Access to Albuterol in Schools: From Policy to Implementation. An Official ATS/AANMA/ALA/NASN Policy Statement

Rationale: For children with asthma, access to quick-relief medications is critical to minimizing morbidity and mortality. An innovative and practical approach to ensure access at school is to maintain a supply of stock albuterol that can be used by any student who experiences respiratory distress. To make this possible, state laws allowing for stock albuterol are needed to improve medication access. Objectives: To provide policy recommendations and outline steps for passing and implementing stock albuterol laws. Methods: We assembled a diverse stakeholder group and reviewed guidelines, literature, statutes, regulations, and implementation documents related to school-based medication access. Stakeholders were divided into two groups—legislation and implementation—on the basis of expertise. Each group met virtually to review documents and draft recommendations. Recommendations were compiled and revised in iterative remote meetings with all stakeholders. Main Results: We offer several recommendations for crafting state legislation and facilitating program implementation. 1) Create a coalition of stakeholders to champion legislation and implement stock albuterol programs. The coalition should include school administrators, school nurses and health personnel, parents, or caregivers of children with asthma, pediatric primary care and subspecialty providers (e.g., pulmonologists/allergists), pharmacists, health department staff, and local/regional/national advocacy organizations. 2) Legislative components critical for effective implementation of stock albuterol programs include specifying that medication can be administered in good faith to any child in respiratory distress, establishing training requirements for school staff, providing immunity from civil liability for staff and prescribers, ensuring pharmacy laws allow prescriptions to be dispensed to schools, and suggesting inhalers with valved holding chambers/spacers for administration. 3) Select an experienced and committed legislator to sponsor legislation and guide revisions as needed during passage and implementation. This person should be from the majority party and serve on the legislature’s health or education committee. 4) Develop plans to disseminate legislation and regulations/policies to affected groups, including school administrators, school nurses, pharmacists, emergency responders, and primary/subspecialty clinicians. Periodically evaluate implementation effectiveness and need for adjustments. Conclusions: Stock albuterol in schools is a safe, practical, and potentially life-saving option for children with asthma, whether asthma is diagnosed or undiagnosed, who lack access to their personal quick-relief medication. Legislation is imperative for aiding in the adoption and implementation of school stock albuterol policies, and key policy inclusions can lay the groundwork for success. Future work should focus on passing legislation in all states, implementing policy in schools, and evaluating the impact of such programs on academic and health outcomes.
Will I speak up or remain silent? Workplace ostracism and employee performance based on self-control perspective

ABSTRACT Drawing on the self-control perspective, this study investigated the buffering effect of emotional suppression in reducing the harmful influence of workplace ostracism on employee performance. The research also studied the mediating role of employee silence and voice behaviors based on social exchange theory. We performed moderated mediation analysis on responses received from 159 employees working in the financial industry of the Southern Punjab region of Pakistan. The results showed that workplace ostracism harms employee performance via employee silence and voice behaviors. Furthermore, emotional suppression moderated the mediated relationship between workplace ostracism and employee performance. The results indicated that if ostracized employees adopt voice behavior, emotional suppression cannot aid them in performing better as compared to those who remain silent and regain their self-esteem. Our findings highlight the importance of emotional suppression capability in reducing the damaging outcomes of ostracism in organizational settings.
The regulation landscape of MAPK signaling cascade for thwarting Bacillus thuringiensis infection in an insect host

Host-pathogen interactions are central components of ecological networks where the MAPK signaling pathways act as central hubs of these complex interactions. We have previously shown that an insect hormone modulated MAPK signaling cascade participates as a general switch to trans-regulate differential expression of diverse midgut genes in the diamondback moth, Plutella xylostella (L.) to cope with the insecticidal action of Cry1Ac toxin, produced by the entomopathogenic bacterium Bacillus thuringiensis (Bt). The relationship between topology and functions of this four-tiered phosphorylation signaling cascade, however, is an uncharted territory. Here, we carried out a genome-wide characterization of all the MAPK orthologs in P. xylostella to define their phylogenetic relationships and to confirm their evolutionary conserved modules. Results from quantitative phosphoproteomic analyses, combined with functional validations studies using specific inhibitors and dsRNAs lead us to establish a MAPK “road map”, where p38 and ERK MAPK signaling pathways, in large part, mount a resistance response against Bt toxins through regulating the differential expression of multiple Cry toxin receptors and their non-receptor paralogs in P. xylostella midgut. These data not only advance our understanding of host-pathogen interactions in agricultural pests, but also inform the future development of biopesticides that could suppress Cry resistance phenotypes.
What Does the Future Hold for Patients With Nonalcoholic Steatohepatitis: Diagnostic Strategies and Treatment Options in 2021 and Beyond?

Nonalcoholic steatohepatitis (NASH) can progress to cirrhosis and its complications, including hepatocellular carcinoma. Given that the majority of patients with NASH are asymptomatic, developing screening strategies to identify those individuals at risk for progressive NASH remains a highly unmet need. Furthermore, noninvasive tests that accurately predict disease progression as part of the natural history of NASH or regression in response to treatment are urgently needed to decrease the reliance on repeat liver biopsies. To date, there are no US Food and Drug Administration (FDA)‐approved medications for NASH that can resolve steatohepatitis and lead to fibrosis regression. The lack of FDA‐approved therapy has led to apathy in diagnosis and referral for specialty care. However, several therapeutic agents are rapidly progressing through the different phases of clinical trials with several already in phase 3 programs. In this review, we provide a summary of recent developments in NASH diagnostics and therapeutics that are likely to shape the future management of this underdiagnosed and undertreated disease.
Influence of hip and knee positions on gluteus maximus and hamstrings contributions to hip extension torque production

ABSTRACT Background Diminished gluteus maximus muscle strength has been proposed to be contributory to various lower-limb injuries. As such, it is of clinical importance to perform hip extensor strength testing in a position that biases torque contribution of the gluteus maximus relative to the other hip extensors (i.e. hamstrings). Objectives To determine the relative torque contributions of the gluteus maximus and hamstring muscles in various hip extensor strength testing positions. Methods 13 Young, healthy participants performed maximum isometric hip extension on a dynamometer in 4 different positions that varied in terms of hip and knee flexion. Surface electromyography (EMG) was used to assess activation of gluteus maximus and hamstrings during the maximum isometric contractions. Normalized EMG data were used as an input to determine individual muscle contribution to hip extension torque production using SIMM modeling software. The gluteus maximus/hamstring torque contribution ratio was compared across the 4 positions using a one-way repeated-measures ANOVA. Results The highest gluteus maximus torque contribution value occurred in positions where the hip was flexed to 45°, while the highest hamstring torque contribution occurred in positions in which the knee was fully extended. The gluteus maximus/hamstring torque contribution ratio was highest at 0° of hip extension and 90° of knee flexion. Conclusion Testing isometric hip extensor strength at 0° of hip extension and 90° of knee flexion should be considered in order to bias torque production of the gluteus maximus relative to the hamstrings.
Identifying False Human Papillomavirus (HPV) Vaccine Information and Corresponding Risk Perceptions From Twitter: Advanced Predictive Models

Background The vaccination uptake rates of the human papillomavirus (HPV) vaccine remain low despite the fact that the effectiveness of HPV vaccines has been established for more than a decade. Vaccine hesitancy is in part due to false information about HPV vaccines on social media. Combating false HPV vaccine information is a reasonable step to addressing vaccine hesitancy. Objective Given the substantial harm of false HPV vaccine information, there is an urgent need to identify false social media messages before it goes viral. The goal of the study is to develop a systematic and generalizable approach to identifying false HPV vaccine information on social media. Methods This study used machine learning and natural language processing to develop a series of classification models and causality mining methods to identify and examine true and false HPV vaccine–related information on Twitter. Results We found that the convolutional neural network model outperformed all other models in identifying tweets containing false HPV vaccine–related information (F score=91.95). We also developed completely unsupervised causality mining models to identify HPV vaccine candidate effects for capturing risk perceptions of HPV vaccines. Furthermore, we found that false information contained mostly loss-framed messages focusing on the potential risk of vaccines covering a variety of topics using more diverse vocabulary, while true information contained both gain- and loss-framed messages focusing on the effectiveness of vaccines covering fewer topics using relatively limited vocabulary. Conclusions Our research demonstrated the feasibility and effectiveness of using predictive models to identify false HPV vaccine information and its risk perceptions on social media.
StrokeCog Markov Model

Supplemental Digital Content is available in the text. Background and Purpose: Cognitive impairment no dementia (CIND) and dementia are common stroke outcomes, with significant health and societal implications for aging populations. These outcomes are not included in current epidemiological models. We aimed to develop an epidemiological model to project incidence and prevalence of stroke, poststroke CIND and dementia, and life expectancy, in Ireland to 2035, informing policy and service planning. Methods: We developed a probabilistic Markov model (the StrokeCog model) applied to the Irish population aged 40 to 89 years to 2035. Data sources included official population and hospital-episode statistics, longitudinal cohort studies, and published estimates. Key assumptions were varied in sensitivity analysis. Results were externally validated against independent sources. The model tracks poststroke progression into health states characterized by no cognitive impairment, CIND, dementia, disability, stroke recurrence, and death. Results: We projected 69 051 people with prevalent stroke in Ireland in 2035 (22.0 per 1000 population [95% CI, 20.8–23.1]), with 25 274 (8.0 per 1000 population [95% CI, 7.1–9.0]) of those projected to have poststroke CIND, and 12 442 having poststroke dementia (4.0 per 1000 population [95% CI, 3.2–4.8]). We projected 8725 annual incident strokes in 2035 (2.8 per 1000 population [95% CI, 2.7–2.9]), with 3832 of these having CIND (1.2 per 1000 population [95% CI, 1.1–1.3]), and 1715 with dementia (0.5 per 1000 population [95% CI, 0.5–0.6]). Life expectancy for stroke survivors at age 50 was 23.4 years (95% CI, 22.3–24.5) for women and 20.7 (95% CI, 19.5–21.9) for men. Conclusions: This novel epidemiological model of stroke, poststroke CIND, and dementia draws on the best available evidence. Sensitivity analysis indicated that findings were robust to assumptions, and where there was uncertainty a conservative approach was taken. The StrokeCog model is a useful tool for service planning and cost-effectiveness analysis and is available for adaptation to other national contexts.
A comprehensive review on choice of hybrid vehicles and power converters, control strategies for hybrid electric vehicles

A worldwide shift headed for a greener and low emissions will necessitate remarkable advancement in the way in which the energy is being produced and used. The factors such as climate changes induced by pollution, progressively more strict emissions norms for vehicles, depletion of petrol/diesel along with instability in their prices for transportation systems, play a vital role in the improvisation of technology involved in conventional vehicles. The hybrid electric vehicles (HEVs) are on the peak of the list of choices available for clean vehicle technologies. The various architectures of HEV, different methodologies of hybrid vehicle, are focused in this paper. The design criteria and optimization techniques with reference to the driving cycle is also elucidated. The various electric drives used for HEV are discussed in this paper. Also, the different electric propulsion systems are explained. To improve the fuel economy and emission of hybrid power system, control strategies are very significant. Researchers concentrate in optimizing the performance of HEV.
Forward osmosis water desalination: Fabrication of graphene oxide-polyamide/polysulfone thin-film nanocomposite membrane with high water flux and low reverse salt diffusion

ABSTRACT This paper investigates the synthesis of graphene oxide (GO)-incorporated polyamide thin-film nanocomposite (TFN) membranes on polysulfone substrate for forward osmosis applications. The GO nanosheets were embedded into polyamide layer using different concentrations (0.05−0.2 wt%). The results represented the alteration of polyamide surface by GO nanosheets and enhancing the surface hydrophilicity by increasing the GO loading. The results showed that the water flux for 0.1 wt% GO embedded nanocomposite (TFN) membrane was 34.7 L/m2 h, representing 90% improvement compared to the thin-film composite, while the salt reverse diffusion was reduced up to 39%.
Vaccination for Influenza - Consumer Health Information

Abstract Seasonal influenza is responsible for millions of hospitalizations and thousands of deaths each year and is a major global health problem. It is important for everyone to receive the influenza vaccine, but it is especially important for young children, the elderly, and those who are immunocompromised. The sites discussed will help consumers understand the importance of the vaccine.
The Health Literacy Questionnaire

Abstract The Health Literacy Questionnaire, a reliable and valid tool, created in 2013, has been translated into multiple languages and used in different settings all over the world in Eastern and Western cultures. Is it a tool that will determine the level of health literacy for the customers of a hospital library or consumer health library? Will it reflect the level of health literacy for public library users in the United States? This column dissects the essence and questions of the Health Literacy Questionnaire and suggests ways to successfully use it.
Enacting Interdisciplinarity: Lessons from Crafting a Multi-Dimensional, Experiential Field Study

Above and beyond the topical content of any given course— which would be in intent of (higher) education anywhere, even “at home”—the goals of international education are fairly grandiose: “to develop an awareness of self outside one’s own culture, to promote intercultural communication, and to encourage flexibility in adapting to a rapidly changing world” (Rotabi, Gammonley, and Gamble 2006, 453). Opportunities for study abroad have blossomed over the past several decades, though the practice is far from new. The benefits of study abroad are so well known, in fact, that some have begun to advocate for a more generalized conception of “study away” versus (only) “study abroad. ” Sobania and Braskamp (2009), for example, argue that the main benefits of study abroad—acquiring a culturally sensitive perspective, improving flexibility and adaptability in unfamiliar situations, and increasing overall confidence and global awareness—are achievable even in domestic locales. The idea is that by relocalizing “away” exercises, program providers and faculty can capitalize on the lower cost of developing domestic programs and the fact the US has become so diverse that one need not travel far to interact with different cultural groups, meaning that students need not worry about going far when they can reach the same goals in a more attainable fashion (Sobania and Braskamp 2009). Though written more than a decade ago, the authors’ argument is especially pertinent in the contemporary moment, wherein the coronavirus pandemic has upended all of our programs, here and abroad. In other words, in a post(? )-COVID world, the notion that quality cross-cultural learning can occur in settings and modalities different from the ones we are used to—namely, those that are closer to home—is a compelling one at this particular time (and, indeed, may prove especially useful if higher education does not return to “normal” promptly). Challenges aside, the benefits of approaching and engaging with the perspectives of another culture—whether that interaction occurs close to or far from home—nevertheless retain their value: “Study abroad is an early form of experiential learning . that allows students to put into practice the academic and theoretical . embod[ying] the art of connecting to the other, of cultivating a mutually constitutive definition of self and other” (Carney 2018, 89). So, it seems, in some form or another, “study abroad” is here to stay. So how can we best configure study abroad to capture the widest array of benefits?