Miracle-dz/UniFAR-FTUs huggingface dataset:
Preliminary Coastal Vulnerability Assessment for Guangdong Province, Southeast China

ABSTRACT Li, W. ; Xiang, W. ; Wang, H. ; Dong, J.; Xu, H. ; Zhang, J.; Zuo, C. ; Liu, Q. ; Lv, J., and Xie, Q. , 2023. Preliminary coastal vulnerability assessment for Guangdong province, Southeast China. Journal of Coastal Research, 39(3), 509–518. Charlotte (North Carolina), ISSN 0749-0208. Accelerating sea level rise and intensifying extreme marine and weather events pose unprecedented challenges to coastal areas in the context of climate change. As a hotspot of marine disasters, Guangdong has been suffering from severe marine disasters including storms, flooding, coastal erosion, and saltwater intrusion in the last decades. It is essential for coastal management authorities to distinguish vulnerable areas and optimize coastal planning. To help identify the coastal vulnerability patterns of the Guangdong coast, the coastal vulnerability index was used based on integrated physical and socio-economic indicators including relative sea level rise, mean tide range, significant wave height, coastal slope, geomorphology, population, land use, and coastal gross domestic product. Each indicator was assigned five vulnerability classifications from very low to very high (1–5). Results show that about 36.7% of the coastline in Guangdong is highly vulnerable, of which 18.3% of the coastline is very highly vulnerable. About 63.3% of the coastline is in moderate to low vulnerability. In particular, the coastal areas in east of Zhanjiang, Maoming, Yangjiang, Zhuhai, Zhongshan, Guangzhou, west of Shenzhen, east Shanwei, and Chaozhou are more vulnerable to sea level rise, which calls for urgent planning and protective measures.
Computer Analysis of the Inhibition of ACE2 by Flavonoids and Identification of Their Potential Antiviral Pharmacophore Site

In the present study, we investigated the antiviral activities of 17 flavonoids as natural products. These derivatives were evaluated for their in vitro antiviral activities against HIV and SARS-CoV-2. Their antiviral activity was evaluated for the first time based on POM (Petra/Osiris/Molispiration) theory and docking analysis. POM calculation was used to analyze the atomic charge and geometric characteristics. The side effects, drug similarities, and drug scores were also assumed for the stable structure of each compound. These results correlated with the experimental values. The bioinformatics POM analyses of the relative antiviral activities of these derivatives are reported for the first time.
Three-dimensional ray tracing and the method of principal curvature for geometric spreading

abstract A three-dimensional ray method is used to compute three components of ground motion for complex structures involving curved boundaries. The method of principal curvature is developed to compute geometrical spreading of rays. This method, commonly used in electromagnetic wave propagation problems, employs phase matching at model interfaces and analysis of the wave front surface metric as the ray propagates throughout the model. It is an elegant way to examine the characteristics of three-dimensional caustics. Results computed for a two-dimensional canonical basin model with a plane SH -wave source are compared and are found to be in good agreement with those previously obtained by other independent numerical methods. Relaxing the restriction that the incident wave be perpendicular to the basin symmetry axis gives rise to large amplitude vertical and radial motions for incident SH waves and large tangential motions for incident P waves. As in the two-dimensional case, seismic energy is geometrically focused in the central region of the basin but strong later arrivals from the curved boundaries are not well developed in the three-dimensional case. The method is of direct use in analyzing three-dimensional crustal structure from off-azimuth P to S and S to P conversions.
Magnesium Oxide Nanoparticles for the Adsorption of Pentavalent Arsenic from Water: Effects of Calcination

The occurrence of heavy metal ions in water is intractable, and it has currently become a serious environmental issue to deal with. The effects of calcining magnesium oxide at 650 °C and the impacts on the adsorption of pentavalent arsenic from water are reported in this paper. The pore nature of a material has a direct impact on its ability to function as an adsorbent for its respective pollutant. Calcining magnesium oxide is not only beneficial in enhancing its purity but has also been proven to increase the pore size distribution. Magnesium oxide, as an exceptionally important inorganic material, has been widely studied in view of its unique surface properties, but the correlation between its surface structure and physicochemical performance is still scarce. In this paper, magnesium oxide nanoparticles calcined at 650 °C are assessed to remove the negatively charged arsenate ions from an aqueous solution. The increased pore size distribution was able to give an experimental maximum adsorption capacity of 115.27 mg/g with an adsorbent dosage of 0.5 g/L. Non-linear kinetics and isotherm models were studied to identify the adsorption process of ions onto the calcined nanoparticles. From the adsorption kinetics study, the non-linear pseudo-first order showed an effective adsorption mechanism, and the most suitable adsorption isotherm was the non-linear Freundlich isotherm. The resulting R2 values of other kinetic models, namely Webber-Morris and Elovich, were still below those of the non-linear pseudo-first-order model. The regeneration of magnesium oxide in the adsorption of negatively charged ions was determined by making comparisons between fresh and recycled adsorbent that has been treated with a 1 M NaOH solution.
On Quasi-Conformally Flat Quasi-Einstein Spaces with Recurrent Curvature

The present paper deals with a study of quasi-conformally flat quasiEinstein spaces with recurrent curvature. We obtain various necessary and sufficient conditions for such a space to be recurrent (resp. concicularly recurrent, projectively recurrent and conformally recurrent). Also the existence of a quasi-Einstein space is ensured by an example which is neither quasi-conformally flat nor quasi-conformally symmetric . Mathematics Subject Classification: 53B30, 53B50, 53C15.
Expectation vs Reality: Analyzing the Competencies of Software Testing Teams

: Process and product quality are essential to maintain competitiveness in the software industry. Software testing is one of the activities to assess product quality, and its process permeates all phases of the development process lifecycle. However, this requires software testing professionals to master different technical skills and general skills. To reduce the skills gap required for the testing team, it is necessary to conduct a skills assessment of all team members. Given this, the objective of this research is to present the results of a competence assessment based on a competence mapping model aimed at software testing teams. To support this research, a questionnaire was applied to 25 industry professionals from a development company to assess the general and technical skills of all roles in the software testing process. As a result, we identified which competencies managers desire for their testing teams. In addition, we identified how professionals see themselves through a self-assessment based on this competence mapping model. After the evaluation, it was possible to identify which competencies need to be developed to reach the required levels for each role and increase the productivity and quality of the process and the product.
COMBINING DIFFUSIVE SHOCK ACCELERATION WITH ACCELERATION BY CONTRACTING AND RECONNECTING SMALL-SCALE FLUX ROPES AT HELIOSPHERIC SHOCKS

Computational and observational evidence is accruing that heliospheric shocks, as emitters of vorticity, can produce downstream magnetic flux ropes and filaments. This led Zank et al. to investigate a new paradigm whereby energetic particle acceleration near shocks is a combination of diffusive shock acceleration (DSA) with downstream acceleration by many small-scale contracting and reconnecting (merging) flux ropes. Using a model where flux-rope acceleration involves a first-order Fermi mechanism due to the mean compression of numerous contracting flux ropes, Zank et al. provide theoretical support for observations that power-law spectra of energetic particles downstream of heliospheric shocks can be harder than predicted by DSA theory and that energetic particle intensities should peak behind shocks instead of at shocks as predicted by DSA theory. In this paper, a more extended formalism of kinetic transport theory developed by le Roux et al. is used to further explore this paradigm. We describe how second-order Fermi acceleration, related to the variance in the electromagnetic fields produced by downstream small-scale flux-rope dynamics, modifies the standard DSA model. The results show that (i) this approach can qualitatively reproduce observations of particle intensities peaking behind the shock, thus providing further support for the new paradigm, and (ii) stochastic acceleration by compressible flux ropes tends to be more efficient than incompressible flux ropes behind shocks in modifying the DSA spectrum of energetic particles.
Stationary distribution for spinning reflecting diffusions

Stationary distribution for spinning reflecting diffusions Mauricio Andrés Duarte Espinoza Chair of the Supervisory Committee: Krzysztof Burdzy Mathematics This dissertation studies two different types of interaction of diffusion processes with the boundary of a domain D ⊆ Rn, which is assumed to be bounded, and of class C2(Rn). The first process that is studied is obliquely reflected Brownian motion, and it is constructed as the unique Hunt process X properly associated with the following Dirichlet form:
Evaluation of Autonomic Nervous System Dysfunction in Childhood Obesity and Prader–Willi Syndrome

The autonomic nervous system (ANS) may play a role in the distribution of body fat and the development of obesity and its complications. Features of individuals with Prader–Willi syndrome (PWS) impacted by PWS molecular genetic classes suggest alterations in ANS function; however, these have been rarely studied and presented with conflicting results. The aim of this study was to investigate if the ANS function is altered in PWS. In this case-control study, we assessed ANS function in 20 subjects with PWS (6 males/14 females; median age 10.5 years) and 27 body mass index (BMI) z-score-matched controls (19 males/8 females; median age 12.8 years). Standardized non-invasive measures of cardiac baroreflex function, heart rate, blood pressure, heart rate variability, quantitative sudomotor axon reflex tests, and a symptom questionnaire were completed. The increase in heart rate in response to head-up tilt testing was blunted (p < 0.01) in PWS compared to controls. Besides a lower heart rate ratio with Valsalva in PWS (p < 0.01), no significant differences were observed in other measures of cardiac function or sweat production. Findings suggest possible altered sympathetic function in PWS.
Is economic policy uncertainty an excuse for corporate fraud?

This study examines the dynamic relationship between economic policy uncertainty (EPU) and corporate fraud by using a sub-sample time-varying rolling window test. Corporate fraud is classified as fraud incidents (the number of corporate frauds) and fraud magnitude (the severity of corporate frauds). Based on this, we propose an EPU-Fraud Triangle model to evidence that EPU affects corporate fraud by acting on Pressure , Opportunity , and Rationalization . The empirical results show that corporations are more likely to engage in fraud during high EPU periods. Moreover, corporate fraud has positive impacts on EPU. As a result, this study suggests corporations consider fraud consequences and policy trends when making decisions. Additionally, government policymakers should analyze the causes of corporate fraud to develop appropriate policies. In addition, to minimize information asymmetries, investors should pay attention to corporate fraud and remain knowledgeable of national policy trends. Furthermore, the study can contribute to the smooth functioning of macroeconomics and reduce the probability of financial risks.
Moderators and Mediators of the Relationship of Shared Decision-Making and Satisfaction

Background:Evidence suggests that health literacy, perceived availability of information and guidance to adapt to challenges (informational support), and symptoms of depression all have the potential to mediate or moderate the relationship between patient-rated involvement in decisions and satisfaction with care. If so these could be useful targets for improving patient experience. Methods: We prospectively enrolled 130 new adult patients visiting an orthopedic surgeon over a 4-month period. All patients were asked to complete measures of satisfaction with care (21-item Medical Interview Satisfaction Scale), perceived involvement in decisions (9-item Shared Decision-Making Questionnaire), symptoms of depression (the Patient-Reported Outcomes Measurement Information Scale [PROMIS] Depression Computerized Adaptive Test [CAT]), perceived availability of information and guidance to adapt to challenges (PROMIS Informational Support CAT), and the Newest Vital Sign test of health literacy. Results: The strong correlation between satisfaction with care (ρ = 0.60, P < .001) and perceived involvement in decisions was neither mediated nor moderated by health literacy, perceived availability of information and guidance, and symptoms of depression. Conclusions: The observation that patient-rated shared decision-making is strongly related to satisfaction with an office visit, independent of health literacy, perceived support, and symptoms of depression, is consistent with evidence that various measures of patient experience tend to correlate and emphasizes the importance of the patient–clinician relationship. Level of Evidence: Level II, prospective study.
Factors Affecting Nest Site Selection by Freshwater Turtles: A Systematic Review

Nest site selection is an important behavior, particularly in species that lack parental care, as nest microclimate can greatly impact embryos’ survival and offspring phenotype. Understanding which factors influence oviposition decisions is critical to identifying priority areas for conservation. This systematic review aimed to synthesize the factors that affect nest site selection by freshwater turtles. The search was conducted in the Web of Science database. In total, 35 publications met the eligibility criteria. The first study on the topic was published more than three decades ago, but only within the last ten years have studies started to be published annually. More than half of the studies were conducted in the United States and the most studied species was Chrysemys picta. Environmental factors, mainly vegetation characteristics, but also soil properties and beach morphology, are the most studied. Anthropogenic factors have been increasingly studied, especially residential areas and agricultural fields. Some studies suggest that human-altered habitats may act as ecological traps, emphasizing the need for further research on this topic. More studies are also needed on the influence of predation risk, co-species cues, female size, and offspring phenotype on nest site selection by freshwater turtles. We highlight that understanding the factors affecting nest site selection is important for identifying the habitat needs of nesting females, predicting possible ecological implications of nest site choice, assessing the adaptive potential of species to environmental change, and determining the vulnerability of populations to different threats.
Introduction to a Twin Dual-Axis Robotic Platform for Studies of Lower Limb Biomechanics

This paper presents a twin dual-axis robotic platform system which is designed for the characterization of postural balance under various environmental conditions and quantification of bilateral ankle mechanics in 2 degrees-of-freedom (DOF) during standing and walking. Methods: Validation experiments were conducted to evaluate performance of the system: 1) to apply accurate position perturbations under different loading conditions; 2) to simulate a range of stiffness-defined mechanical environments; and 3) to reliably quantify the joint impedance of mechanical systems. In addition, several human experiments were performed to demonstrate the system’s applicability for various lower limb biomechanics studies. The first two experiments quantified postural balance on a compliance-controlled surface (passive perturbations) and under oscillatory perturbations with various frequencies and amplitudes (active perturbations). The second two experiments quantified bilateral ankle mechanics, specifically, ankle impedance in 2-DOF during standing and walking. The validation experiments showed high accuracy of the platform system to apply position perturbations, simulate a range of mechanical environments, and quantify the joint impedance. Results of the human experiments further demonstrated that the platform system is sensitive enough to detect differences in postural balance control under challenging environmental conditions as well as bilateral differences in 2-DOF ankle mechanics. This robotic platform system will allow us to better understand lower limb biomechanics during functional tasks, while also providing invaluable knowledge for the design and control of many robotic systems including robotic exoskeletons, prostheses and robot-assisted balance training programs. Clinical and Translational Impact Statement— Our robotic platform system serves as a tool to better understand the biomechanics of both healthy and neurologically impaired individuals and to develop assistive robotics and rehabilitation training programs using this information.
Pelvic Floor Muscle Training versus Functional Magnetic Stimulation for Stress Urinary Incontinence in Women: A Randomized Controlled Trial

Background: There is strong evidence that specific pelvic floor muscle training (PFMT) reduces stress urinary incontinence (SUI), but the application of functional magnetic stimulation (FMS) is still under discussion. Objective: To evaluate and compare the effects of FMS and PFMT on pelvic floor muscle function, urinary incontinence symptoms and quality of life (QoL) in women with SUI. Methods: A randomized controlled, parallel-group trial was executed in an outpatient physical medicine and rehabilitation centre. The study included 68 women and was fully completed by 48 women (n = 24 in each group) aged 29–49 years, with SUI, who were randomly assigned to PFMT and FMS groups. The symptoms of urinary incontinence and their impact on quality of life were assessed with two questionnaires: the International Consultation on Incontinence Questionnaire–Short Form (ICIQ-SF) and the Incontinence Impact Questionnaire–Short Form (IIQ-7). Perineometer (Pelvexiser) was used to measure the resting vaginal pressure, pelvic floor muscle (PFM) strength and endurance. All outcome measures were taken at baseline and after 6 weeks of interventions. Cohen’s effect size (d) was calculated. Results: A significant improvement (p < 0.05) of ICIQ-SF and IIQ-7 was observed in both groups with a high effect size in the PFMT group (d = 1.56 and d = 1.17, respectively) and the FMS group (d = 1.33 and d = 1.45, respectively). ICIQ-SF and IIQ-7 scores did not differ significantly between groups after the 6-week treatment period. Resting vaginal pressure, PFM strength and endurance increased (p < 0.05) in both groups with a medium (d = 0.52) to large (d = 1.56) effect size. Conclusion: No significant difference between groups was found in any measurement of perineometry. PFMT and FMS significantly improved SUI symptoms and the quality of life of the study participants. None of the applied interventions was superior to the other in the short-term effect.
Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer’s Disease

Alzheimer’s disease (AD) is a prevalent type of dementia in elderly populations with a significant genetic component. The accumulating evidence suggests that AD involves a reconfiguration of the epigenetic landscape, including DNA methylation, post-translational modification of histone proteins, and chromatin remodeling. Along with environmental factors, individual specific genetic features play a considerable role in the formation of epigenetic architecture. In this study, we attempt to identify the non-coding regulatory SNPs (rSNPs) able to affect the epigenetic mechanisms in AD. To this end, the multi-omics approach is used. The GEO (Gene Expression Omnibus) available data (GSE153875) for AD patients and controls are integrated to reveal the rSNPs that display allele-specific features in both ChIP-seq profiles of four histone modifications and RNA-seq. Furthermore, we analyze the presence of rSNPs in the promoters of genes reported to be differentially expressed between AD and the normal brain (AD-related genes) and involved in epigenetic regulation according to the EpiFactors database. We also searched for the rSNPs in the promoters of the genes coding for transcription regulators of the identified AD-related genes. These regulators were selected based on the corresponding ChIP-seq peaks (ENCODE) in the promoter regions of these genes. Finally, we formed a panel of rSNPs localized to the promoters of genes that contribute to the epigenetic landscape in AD and, thus, to the genetic predisposition for this disease.
Molecular Toxicity Mechanism Induced by the Antibacterial Agent Triclosan in Freshwater Euglena gracilis Based on the Transcriptome

Triclosan (TCS), a commonly used antibacterial preservative, has been demonstrated to have high toxicological potential and adversely affects the water bodies. Since algae are one of the most significant primary producers on the planet, understanding the toxicological processes of TCS is critical for determining its risk in aquatic ecosystems and managing the water environment. The physiological and transcriptome changes in Euglena gracilis were studied in this study after 7 days of TCS treatment. A distinct inhibition ratio for the photosynthetic pigment content in E. gracilis was observed from 2.64% to 37.42% at 0.3–1.2 mg/L, with TCS inhibiting photosynthesis and growth of the algae by up to 38.62%. Superoxide dismutase and glutathione reductase significantly changed after exposure to TCS, compared to the control, indicating that the cellular antioxidant defense responses were induced. Based on transcriptomics, the differentially expressed genes were mainly enriched in biological processes involved in metabolism pathways and microbial metabolism in diverse environments. Integrating transcriptomics and biochemical indicators found that changed reactive oxygen species and antioxidant enzyme activities stimulating algal cell damage and the inhibition of metabolic pathways controlled by the down-regulation of differentially expressed genes were the main toxic mechanisms of TCS exposure to E. gracilis. These findings establish the groundwork for future research into the molecular toxicity to microalgae induced by aquatic pollutants, as well as provide fundamental data and recommendations for TCS ecological risk assessment.