Miracle-dz/UniFAR-FTUs huggingface dataset:
Disruption of seismic images by the parabolic Radon transform

Integral transforms have always been a powerful tool to analyze seismic data in one and higher dimensions. The shift and similarity theorems for the 2D linear Radon transform or the slope-intercept form are given in terms of an affine coordinate transform (Deans, 1983). The best known example is that a shift in space domain of a hyperbolic traveltime curve yields a rotation of the image (an ellipse) in the slope-intercept domain (Durrani and Bisset, 1984). Hence, if seismic data are slightly modified by a shift (delay) or a change of scale (magnification), the new image is not essentially different from the old image. The 2D parabolic Radon transform is a mapping from the space–time domain onto a domain defined by the curvature intercept of parabolas present in the data (Hampson, 1986; Zhou and Greenhalgh, 1994). Similarity theorems for this transform can be established; however, a shift in space domain does not imply affine transforms, such as rotation, dilation, or translation of the transform coordinates. Lack of symmetry because of dipping reflectors or lateral velocity gradients deteriorates the qualitative nature of seismic data. Since the parabolic Radon transform is often used for primary/multiple separation, there will be a peg-leg multiple splitting, and the peg-leg multiples will appear as curves with the apex at nonzero offset. Hence, small deviations and deformations of seismic data from the ideal are always present in practice, so the actual image in the curvature-intercept domain can be highly distorted and may not resemble the ideal image at all.
A Review of FXIa Inhibition as a Novel Target for Anticoagulation

Abstract Limitations of vitamin K antagonists as chronic oral anticoagulant therapy have largely been supplanted by direct factor IIa and factor Xa inhibitor oral anticoagulants with similar efficacy but an overall better safety profile, lack of routine monitoring, and very limited drug–drug interactions compared with agents such as warfarin. However, an increased risk of bleeding remains even with these new-generation oral anticoagulants in fragile patient populations, in patients requiring dual or triple antithrombotic therapy, or high bleed risk surgeries. Epidemiologic data in patients with hereditary factor XI deficiency and preclinical studies support the notion that factor XIa inhibitors have the ability to be an effective but potentially safer alternative to existing anticoagulants, based on their ability to prevent thrombosis directly within the intrinsic pathway without affecting hemostatic mechanisms. As such, various types of factor XIa inhibitors have been studied in early phase clinical studies, including inhibitors of the biosynthesis of factor XIa with antisense oligonucleotides or direct inhibitors of factor XIa using small peptidomimetic molecules, monoclonal antibodies, aptamers, or natural inhibitors. In this review, we discuss how different types of factor XIa inhibitors work and present findings from recently published Phase II clinical trials across multiple indications, including stroke prevention in atrial fibrillation, dual pathway inhibition with concurrent antiplatelets post–myocardial infarction, and thromboprophylaxis of orthopaedic surgery patients. Finally, we refer to ongoing Phase III clinical trials of factor XIa inhibitors and their potential to provide definitive answers regarding their safety and efficacy in preventing thromboembolic events in specific patient groups.
Wet cupping therapy increases the time withdrawal latency (TWL) and decreases GABA-A receptor expression in the spinal cord in a rat model of neuropathic pain

Background & Objective: Neuropathic pain (NP) is a pain due to a somatosensory lesion. NP leads to disruption of health, work, social relationships, hobbies, sleep, mood, and cognitive function. Up till now, the treatment of NP remains unsatisfactory. It makes many patients seek alternative therapies, including wet cupping therapy (WCT). We aimed to analyze the effects of WCT against NP in chronic constriction injury (CCI) in a rat model by assessing the increase in time withdrawal latency (TWL) and GABA-A receptors expression in the spinal cord. Methodology: We used CCI as one of the NP models in Rattus norvegicus species of rats and treated with WCT. We used 21 four months old male rats, divided into 3 groups (n = 7); P1 (sham CCI group), P2 (CCI group), and P3 (CCI plus WCT group). WCT was given two times every week for three weeks with 5 min of first cupping using −200 mmHg, and followed by ten punctures and then 5 min of second cupping using −200 mmHg. TWL assesment was conducted by using hotplate. Expresion of GABA-A receptor was evaluated with immunohistochemistry. Results: WCT significantly increased TWL with P = 0.0001 and decreased expresion of GABA-A receptors in the spinal cord of CCI rat model. Conclusion: This research concluded that wet cupping therapy could increase time withdrawal latency and decrease the expression of GABA-A receptors in the spinal cord in chronic constriction injury rat model. This result suggests a promising method in controlling neuropathic pain. However, further investigations are required to understand the mechanism. Abbreviations: CCI: Chronic Constriction Injury; CT: Cupping Therapy; DCT: Dry Cupping Therapy; NP: Neuropathic Pain; TWL: Time Withdrawal Latency; WCT: Wet Cupping Therapy; Key words: Chronic constriction injury; CCI rat model; GABA-A receptors; Neuropathic pain; Pain; Time withdrawal latency; TWL; Wet cupping therapy. Citation: Hidayati HB, Qurnianingsih E, Widjiati, Khaerunnisa S, Puspamaniar VA, Susetyo RD. Wet cupping therapy increases the time withdrawal latency (TWL) and decreases GABA-A receptor expression in the spinal cord in a rat model of neuropathic pain. Anaesth. pain intensive care 2022;27(1):97−103; DOI: 10.35975/apic.v27i1. 2124 Received: July 05, 2022; Reviewed: July 08,2022; Accepted: December 12, 2022
Wave Propagation in a Random Medium

sity, the ? )wss-centered diffusion flux must be considered, which implies that the appropriate concentration variable is the mass fraction. I t is often necessary to use the mass-centered system for another reason also: When chemical reaction occurs, moles are not conserved, whereas mass is; the mass fraction also recommends itself when the molecular weight of the diffusing substance is uncertain, as in the case of a hydrocarbon fuel diffusing toward a flame. The reviewer did not find in the book any statement of the above views (which may be wrong) or of any alternative recommendations for dealing with problems of this kind, which arise in almost every practical application of masstransfer theory. I t would, however, be entirely unfitting to close this review on a critical note. The reviewer has therefore saved until the end an expression of his profound admiration for a work which is scholarly, lucid, and elegant. The authors have taken almost unprecedented pains to aid the student's labors; careful definitions, helpful notation, lively examples, ancl handsome printing make this work one of which the authors, and the publishing house, can take a well-justified pride. Students, teachers, and industrial scientists will be grateful to them for a long time to come.
Influence of bias voltage on dielectric relaxation of nanocrystalline anatase TiO2 using modulus formalism

Dielectric relaxation in sol–gel-derived anatase titanium oxide nanocrystals (6, 9, and 20 nm) has been investigated using impedance spectroscopy in a wide frequency range from 1 Hz to 1 MHz as a function of applied DC bias voltage, ranging from 0 to 4.2 V in a periodic interval of 0.3 V. Under the equilibrium condition, around three order of magnitude variations in the dielectric relaxation time (τ) was observed for the grain size if reduced to 6 nm from 20 nm. An unambiguous evidence for the absence of such a crystallite size effect was experimentally observed in higher biased conditions because of grain boundarySchottky potential barrier height suppression. These experimental results obey the “grain boundary double Schottky barrier model. ”
Bifurcations in the interplay of messenger RNA, protein and nonprotein coding RNA

The interplay of messenger RNA (mRNA), protein, produced via translation of this RNA, and nonprotein coding RNA (ncRNA) may include regulation of the ncRNA production by protein and (i) ncRNA–protein association resulting in suppression of the protein regulatory activity or (ii) ncRNA–mRNA association resulting in degradation of the miRNA–mRNA complex. The kinetic models describing these two scenarios are found to predict bistability provided that protein suppresses the ncRNA formation.
Ethnopharmacological Potential of Phytochemicals and Phytogenic Products against Human RNA Viral Diseases as Preventive Therapeutics

RNA viruses have been the most destructive due to their transmissibility and lack of control measures. Developments of vaccines for RNA viruses are very tough or almost impossible as viruses are highly mutable. For the last few decades, most of the epidemic and pandemic viral diseases have wreaked huge devastation with innumerable fatalities. To combat this threat to mankind, plant-derived novel antiviral products may contribute as reliable alternatives. They are assumed to be nontoxic, less hazardous, and safe compounds that have been in uses in the beginning of human civilization. In this growing COVID-19 pandemic, the present review amalgamates and depicts the role of various plant products in curing viral diseases in humans.
Anomalous Reflection From a Phase Gradient Metasurface With Arbitrary Incident Angle

A planar phase gradient metasurface (PGM) with phase gradients in two in-plane directions will introduce two additional wave vectors to the reflected wave vector. For small incident angles, close to the normal vector, the magnitude of the reflected wave vector is smaller than that of the incident wave vector and the direction of the anomalous reflected wave can be determined from the incident wave vector components and additional phase gradient components. The expanded generalized Snell’s law, which includes diffraction order modes, is combined with array theory to accurately predict the directions of the reflected waves from a planar PGM for incident angles where the magnitude of the reflected wave vector is larger than that of the incident wave vector. The predicted directions of the reflected waves from a planar PGM are compared with simulated RCS results obtained with CST Studio Suite and measured results obtained in a compact range.
Analytical study on the dynamic displacement response of a curved track subjected to moving loads

A closed-form out-of-plane dynamic displacement response of a curved track subjected to moving loads was proposed. The track structure was modeled as a planar curved Timoshenko beam periodically supported by the double-layer spring-damping elements. The general dynamic displacement response induced by the moving loads along the curve on the elastic semi-infinite space was firstly obtained in the frequency domain, according to the Duhamel integral and the dynamic reciprocity theorem. In the case of the periodic curved track structure subjected to moving loads, the dynamic displacement equation was simplified into a form of summation within the basic track cell instead of the integral. The transfer function for the curved track was expressed in the form of a transfer matrix. Single and series moving loads were involved in the calculation program. For the verification of the analytical model, the mid-span vertical deflection of a simply support curved beam subjected to moving load was recalculated and compared with the same case in the reference. The research results indicate that: under the same moving loads, the displacement response of the curved track decreases slightly with the increasing track radius, and the displacement response of the curved track with the radius greater than or equal to 600 m is almost equivalent to the displacement response of the straight track; the frequency spectrum of the curved track is more abundant than that of the straight track, which may result in more wheel-rail resonance and rail corrugation in the curved lines.
Genetics, Treatment, and New Technologies of Hormone Receptor-Positive Breast Cancer

Simple Summary In this review paper, we focused on the discussion of various important aspects of hormone receptor (HR)-positive breast cancer, including HR structure and signaling, genetics (epigenetics and gene mutations), gene expression-based assays, traditional and new drugs for treatment, and new technological uses in diagnosis and treatment. Particularly, we summarized the commonly mutated genes and abnormally methylated genes in HR-positive breast cancer and compared the common gene expression-based assays that are used in breast cancer as prognostic and/or predictive tools in detail. All of these topic discussions have not been fully described and summarized within other research or review articles. Abstract The current molecular classification divides breast cancer into four major subtypes, including luminal A, luminal B, HER2-positive, and basal-like, based on receptor gene expression profiling. Luminal A and luminal B are hormone receptor (HR, estrogen, and/or progesterone receptor)-positive and are the most common subtypes, accounting for around 50–60% and 15–20% of the total breast cancer cases, respectively. The drug treatment for HR-positive breast cancer includes endocrine therapy, HER2-targeted therapy (depending on the HER2 status), and chemotherapy (depending on the risk of recurrence). In this review, in addition to classification, we focused on discussing the important aspects of HR-positive breast cancer, including HR structure and signaling, genetics, including epigenetics and gene mutations, gene expression-based assays, the traditional and new drugs for treatment, and novel or new uses of technology in diagnosis and treatment. Particularly, we have summarized the commonly mutated genes and abnormally methylated genes in HR-positive breast cancer and compared four common gene expression-based assays that are used in breast cancer as prognostic and/or predictive tools in detail, including their clinical use, the factors being evaluated, patient demographics, and the scoring systems. All these topic discussions have not been fully described and summarized within other research or review articles.
Disease-Modifying Adjunctive Therapy of Osteopenia and Osteoporosis with a Multimineral Marine Extract, LithoLexal® Bone

There is evidence to suggest that restoration of major/rare biominerals by supplementation can produce osteogenic and anti-resorptive effects in humans. LithoLexal® is a natural extract harvested from a marine alga, Lithothamnion sp. , with a porous microstructure and multimolecular composition rich in calcium (32% w/w) and magnesium (2.2% w/w) together with ~72 trace bioelements. In vitro, LithoLexal® demonstrated cellular-level osteogenic efficacy through enhancing the maturation and activity of pre-osteoblasts. This extract also expressed the ability to suppress osteoclastogenesis by downregulating the pro-resorptive cytokines TNF-α and IL-1β and the master regulator of inflammation NF-κB. Parathyroid hormone inhibition of parathyroid hormone secretion is another bioactivity of LithoLexal® Bone reported with both short- and long-term administration at a longer duration and higher magnitude than what calcium carbonate could induce. Due to these bioactivities that affect pathogenetic factors of osteoporosis, LithoLexal® Bone is referred to as a disease-modifying adjunctive therapy (DMAT). In postmenopausal animal models, LithoLexal® monotherapy preserved bone mineral density, microarchitecture, and biomechanical properties, while calcium carbonate failed to produce significant outcomes. The pro-resorptive effect of a high-fat diet was also efficiently counteracted in vivo by supplementary LithoLexal®. A large clinical trial on postmenopausal women verified the mitigating effects of LithoLexal® Bone on bone resorption and turnover rate. The characteristic composition of LithoLexal® together with its lattice microstructure are suggested to underlie its in vivo bioactivities. In conclusion, adjunctive therapy with LithoLexal® Bone is an attractive option for clinical prevention and treatment of osteopenia/osteoporosis.
A New Single-Source Nine-Level Quadruple Boost Multi-Level Inverter with Common Ground

This paper introduces a novel switched capacitor multilevel inverter (SCMLI) with common ground and voltage boosting capabilities. The proposed converter can produce nine levels and a voltage boosting of four times with a single dc source. For boosting the voltage, three self-balanced switched capacitors are used with ten switches and one diode. For controlling the output voltage, a level-shifted modulation technique is used. The operation of the proposed SCMLI and the design of capacitors for the proposed circuit is discussed in detail. The presence of common ground is useful for the elimination of leakage current, especially in renewable power applications. The proposed converter is compared with some other recently introduced converters in terms of voltage gain, the number of components used, and availability of common ground. For verifying the performance of the proposed circuit, the experimental results are presented in the paper. The total harmonic distortion (THD) is 12.1% and the experimental results closely agree with the simulation and theoretical studies.
THE ROLE OF HUMAN RESOURCE MANAGEMENT IN IMPROVING EMPLOYEE PERFORMANCE IN PRIVATE COMPANIES

A company needs employees with good performance. Through this good performance, the company can compete and develop into a bigger company. There are various strategies to improve employee performance, one of which is human resource management. This study aims to see the role of human resource management in enhancing employee performance in private companies. This research will be carried out using a descriptive qualitative approach. The data used in this study comes from various research results and previous studies, which still have relevance to the contents of this research. This study then found a positive influence of human resource management on improving employee performance in private companies. This is due to the fact that human resource management requires three essential roles: the administrative role, the operational role, and the strategic role. Humans are the source of all the company's problems, hence these three positions are vital to its management.
A fast sequential algorithm for least-squares filtering and prediction

A new computationally efficient algorithm for sequential least-squares (LS) estimation is presented in this paper. This fast a posteriori error sequential technique (FAEST) requires 5p MADPR (multiplications and divisions per recursion) for AR modeling and 7p MADPR for LS FIR filtering, where p is the number of estimated parameters. In contrast the well-known fast Kalman algorithm requires 8p MADPR for AR modeling and 10p MADPR for FIR filtering. The increased computational speed of the introduced algorithm stems from an alternative definition of the so-called Kalman gain vector, which takes better advantage of the relationships between forward and backward linear prediction.
Unpacking corporate ownership in property markets: A typology of investors and the making of an investment value chain in Brazil

Over the past few decades, a growing number of studies have analyzed the social, spatial, and economic consequences of the sharp rise in corporate ownership of property assets. These studies have shown that financial(ized) rationalities, preferences, and techniques increasingly shape the investment behavior of corporate landlords, with notable effects in cities and regions. Less attention has been given, however, to the heterogeneity of actors that are bundled together under the umbrella of corporate landlords, as well as to the investment strategies these different actors pursue. In this paper, we aim to fill this gap by analyzing the investment behavior of three corporate and financial investors in Brazil's commercial property markets: pension funds; listed property firms; and real estate investment trusts. Drawing on institutional and evolutionary approaches to economic geography, we build a typology of investor types in Brazil's commercial property markets which shows that the investment preferences of these actors are largely shaped by three key variables: their organizational rules and routines; their ownership structure; and differential access to financing. In addition, we show that these investment preferences translate into distinguishable patterns of property investment and influence broader property market dynamics by giving shape to an investment value chain.
Past, Present, and Future of Naturally Occurring Antimicrobials Related to Snake Venoms

Simple Summary A critical global health problem is microbial resistance to antibiotics. In order to further discuss this issue and search for practical means to overcome such problems, we reviewed the bibliography related to snake venoms, their proteins, and peptides with antimicrobial activity because many of them have the potential to become alternative antimicrobial agents or serve as lead compounds for the development of new ones. Among the proteins classified according to their structures are lectins, metalloproteinases, L-amino acid oxidases, phospholipases type A2, cysteine-rich secretory proteins, and serine proteinases. Among the oligopeptides are waprins, cardiotoxins, cathelicidins, and β-defensins. The list includes natural and synthetic small peptides, many derived from the proteins and the oligopeptides cited above. In vitro, all these snake-venom components are active against bacteria, fungi, parasites, and/or viruses pathogenic to humans. Some have also been tested in laboratory animals. In addition to organizing and discussing such an expressive amount of information, we propose here a multidisciplinary approach that includes sequence phylogeny as a way to better understand the relationship between amino-acid sequence and antimicrobial activity. Abstract This review focuses on proteins and peptides with antimicrobial activity because these biopolymers can be useful in the fight against infectious diseases and to overcome the critical problem of microbial resistance to antibiotics. In fact, snakes show the highest diversification among reptiles, surviving in various environments; their innate immunity is similar to mammals and the response of their plasma to bacteria and fungi has been explored mainly in ecological studies. Snake venoms are a rich source of components that have a variety of biological functions. Among them are proteins like lectins, metalloproteinases, serine proteinases, L-amino acid oxidases, phospholipases type A2, cysteine-rich secretory proteins, as well as many oligopeptides, such as waprins, cardiotoxins, cathelicidins, and β-defensins. In vitro, these biomolecules were shown to be active against bacteria, fungi, parasites, and viruses that are pathogenic to humans. Not only cathelicidins, but all other proteins and oligopeptides from snake venom have been proteolyzed to provide short antimicrobial peptides, or for use as templates for developing a variety of short unnatural sequences based on their structures. In addition to organizing and discussing an expressive amount of information, this review also describes new β-defensin sequences of Sistrurus miliarius that can lead to novel peptide-based antimicrobial agents, using a multidisciplinary approach that includes sequence phylogeny.