Miracle-dz/UniFAR-FTUs huggingface dataset:
VHRM_A_320883 771..778

Academic Section of Vascular Surgery, Imperial College London, London, UK Introduction: Neuromuscular stimulation (NMES) has been shown to improve peripheral blood flow in healthy people. We investigated the effect of bilateral leg NMES on the symptoms of chronic venous disease. Methods: Forty subjects were recruited from four groups: healthy, superficial insufficiency, deep insufficiency, and deep obstruction. Haemodynamic venous measurements were taken from the right femoral vein with ultrasound, laser Doppler fluximetry from the left hand and foot. Devices were then worn for 4–6 hours per day, for 6 weeks. Haemodynamic measurements were repeated at week 6. Quality of life questionnaires were taken at week 0, 6 and 8. Results: The mean age was 48.7, BMI 28.6kg/m2, and maximum calf circumference 39.0 cm. Twenty-four subjects were men. NMES increased femoral vein peak velocity, TAMV and volume flow by 55%, 20%, 36% at 20 minutes (all p<0.05), which was enhanced at week 6 (PV and TAMV p<0.05). Mean increases in arm and leg fluximetry were 71% and 194% (both p<0.01). Leg swelling was reduced by mean 252.7 mL (13%, p<0.05) overall; 338.9 mL (16%, p<0.05) in venous disease. For those with venous pathology, scores for disease specific and generic quality of life questionnaires improved. Those with C4-6 disease benefitted the most, with improvements in VDS score of 1, AVVQ of 6, and SF-12 of 10. Conclusion: NMES improves venous haemodynamic parameters in chronic venous disease, which is enhanced by regular use. NMES reduces leg oedema, improves blood supply to the skin of the foot, and may positively affect quality of life. Clinical Trials: This trial was registered with www.clinicaltrials. org.uk (NCT02137499).
Quantum Gravitational Correction and MOND Theory in the Holographic Equipartition Scenario

In this paper, by using Verlinde's formalism and a modified Padmanabhan's prescription, we have obtained the lowest order quantum correction to the gravitational acceleration and MOND-type theory by considering a nonzero difference between the number of bits of the holographic screen and number of bits of the holographic screen that satisfy the equipartition theorem. We will also carry out a phase transition and critical phenomena analysis in MOND-type theory where critical exponents are obtained.
PURIFICATION PERFORMANCE OF FILTRATION PROCESS FOR LEACHATE IN MOROCCO BY MARINE SANDS, CLAYS AND FLY ASH

- This study focuses on the slow filtration of leachates by marine sands and matrix formed by clays A 1 and fly ash which have already given a satisfactory reduction of physicochemical pollution for the same leachate [1]. The determination of sand particle sizes and the mineralogical characterization of sand is an essential step to choose the best samples of sand filter. The filtration device selected allowed us to reach high removal rate for all parameters. The removals rates of COD, BOD 5 ; SS; TP; Electrical conductivity and TKN were 78,46%; 96,13%; 90,23%; 98,54%; 81,53% and 44,82% respectively, according to Moroccan norms of indirect discharges. The metallic ions Al, Cd, Cr, Cu, Fe, Mn, Ni, Pb and Zn are strongly retained with the concentrations less than Moroccan norms of direct discharges, especially for iron with an abatement rate of 99,32% and a concentration < 0,1 mg/L and chromium with an abatement rate > 97,8% and a concentration of 0,2 mg/L. The fecal coliforms and fecal streptococcus are effectively reduced with respective rates of 96% and 92,80%. The use of this filtration technique using dropouts materials, whose investment costs are lower and the sustainability is more great both tech-nically and financially, seems the best convenient solution for developing countries.
MINIREVIEW Diversity, Epidemiology, and Genetics of Class D (cid:1) -Lactamases (cid:1)

Class D (cid:1) -lactamase-mediated resistance to (cid:1) -lactams has been increasingly reported during the last decade. Those enzymes also known as oxacillinases or OXAs are widely distributed among Gram negatives. Genes encoding class D (cid:1) -lactamases are known to be intrinsic in many Gram-negative rods, including Acinetobacter baumannii and Pseudomonas aeruginosa , but play a minor role in natural resistance phenotypes. The OXAs (ca. 150 variants reported so far) are characterized by an important genetic diversity and a great heterogeneity in terms of (cid:1) -lactam hydrolysis spectrum. The acquired OXAs possess either a narrow spectrum or an expanded spectrum of hydrolysis, including carbapenems in several instances. Acquired class D (cid:1) -lac-tamase genes are mostly associated to class 1 integron or to insertion sequences. Class D (cid:1) -lactamases, also known as oxacillinases or OXA-type (cid:1) -lactamases (OXAs), are active-serine-site enzymes like Ambler class A and class C (cid:1) -lactamases, differing from class A and C enzymes in amino acid structure, whereas class B (cid:1) -lac-tamases are metalloenzymes with a Zn 2 (cid:2) ion(s) in
CircRNA_0263 and circRNA_1507 are Dysregulated in Atrial Fibrosis Rat Induced by Chronic Intermittent Hypoxia

Xue Liang Tianjin Medical University Second Hospital Yanhong Liu Tianjin Medical University Second Hospital Yu Liu Tianjin Medical University Second Hospital Weiding Wang Tianjin Medical University Second Hospital Wenfeng Shangguan Tianjin Medical University Second Hospital Manman Wang A liated Hospital of Jining Medical University Xiaowei Zhang Tianjin Medical University Second Hospital Shuai Miao Tianjin Medical University Second Hospital Enzhao Liu Tianjin Medical University Second Hospital Guangping Li (  tic_tjcardiol@126.com ) Tianjin Institute of cardiology,second hospital of Tianjin medical university https://orcid.org/00000003-2424-8548
A new kind of functional differential equations

In this paper we introduce and investigate a new kind of functional (including ordinary and evolutionary partial) differential equations. The main goal of this paper is to explore our new philosophy by some examples on functional ODEs and PDEs. For some typical examples, we prove the global existence of smooth solutions, analyze some interesting properties enjoyed by these solutions, and illustrate the differences between this new class of equations and the traditional ones. This kind of functional differential equations is a new and powerful tool to study some problems arising from both mathematics and physics, more applications in particular to differential geometry and fundamental physics can be expected.
Saccharomyces Cerevisiae Immobilized in Alginate for Continuous Fermentation

— Saccharomyces cerevisiae BY4742 cells were immobilized in alginate and applied for continuous fermentation. Immobilization of yeast cell showed technical and economic advantages over free cell system. In the fermentation, the initial glucose concentration was 110 g/L. The hydraulic retention time (HRT) of fermentation broth was set to 24 h with a re-activate time of 12 h after first incubation period 72 h. Ethanol yield and glucose utilizing ratio were analyzed for verifying the performance of continuous fermentation and the improvement of immobilized yeasts over free yeast cells for fermentation. Comparing dates in two experimental groups, the ethanol yield could reach to about 80% and the glucose utilizing ratio had the similar pattern with averagely 50%. The ethanol yield and glucose utilizing ratio had a significant improvement with the pre-activation and the re-activation.
Attention capital as a result of the emergence of social media Theoretical framework

how its functioning is being profoundly transformed by social media. Although attention capital (measured by e.g. the number of likes or comments) is often translatable into other forms of capital, it remains rather autonomous. While the development of the Internet results in a greater choice of content, which can be selected according to individual preferences, gratification in the form of views is gained not so much by the author of content, but rather by the person who has shared it. This process is even more noticeable in the case of memes, whose authorship often cannot even be ascertained. In this way, changes on the Internet lead to the emergence of a new form of sociocultural economy.
Comparison of the Combination of Butterbur, Riboflavin and Magnesium Versus Topiramate in Migraine Prophylaxis

Objective: To compare the efficacy in migraine prophylaxis of topiramate versus the combination of butterbur, riboflavin and magnesium. Materials and Methods: 124 adults with episodic migraine requiring prophylaxis were enrolled prospectively. 61% received topiramate (TPM) 50 mg/d and 39% received the triple combination therapy (TCT) that consisted of butterbur 150 mg/d, riboflavin 200 mg/d and magnesium 750-1000 mg/d. The subjects were asked to chart the frequency, severity and duration of their headaches over 3 months after initiating their prophylactic treatment. Results: 29 patients in the TPM arm and 25 in the TCT arm were followed- up over 3 months. TPM and TCT decreased the number of headache days per month by 67% and 65% respectively. There was also a decrease in the attack duration by 48% and 52% and in its severity by 3 and 2.6 points on the visual analog scale in the TPM and TCT groups respectively. 13 patients (29%) discontinued their medication due to side effects in the TPM group. Conclusion: Low dose topiramate was as efficacious in migraine prophylaxis as the combination of butterbur, riboflavin and magnesium. However, TPM has more side effects and the TCT is more expensive. at a hospital‐ based neurology 124 The inclusion are 18-65 years old and a diagnosis of episodic migraine with or without aura, as defined by the ICDH-3 criteria, with a frequency of more than 6 headache days per month. were the patients on prophylactic treatment for migraine, antidepressants in the past 3 months and those with co-morbid primary headaches, pregnancy or lactation, renal or hepatic failure, hypertension, kidney
RECONSTRUCTING POSITIONS AND PECULIAR VELOCITIES OF GALAXY CLUSTERS WITHIN 20000 Km/sec

Starting from the observed redshift distribution of a volume limited Abell/ACO cluster sample we use a 2-step procedure to recover their distances and peculiar velocities (assuming linear theory and linear biasing). The resulting 3D dipole is found to be 23\% less than the corresponding z-space one which leads to a value of $\beta \approx 0.21$ consistent with an $\Omega_{\circ}=1$ Universe. The cluster velocity field is dominated by a large-scale streaming motion towards the Shapley concentration and the resulting bulk velocity agrees extremely well with that deduced by POTENT, on smaller scales. Our results are in strong disagreement with those of Lauer \& Postman.
DMSO_A_264851 3691..3702

*These authors contributed equally to this work Abstract: Polychlorinated biphenyls (PCBs) are a typical class of environmental contaminants recently shown to be metabolism-disrupting chemicals. Lipids are a highly complex group of biomolecules that not only form the structural basis of biofilms but also act as signaling molecules and energy sources. Lipid metabolic disorders contribute to multiple diseases, including obesity, diabetes, fatty liver, and metabolic syndromes. Although previous literature has reported that PCBs can affect lipid metabolism, including lipid synthesis, uptake, and elimination, few systematic summaries of the detailed process of lipid metabolism caused by PCB exposure have been published. Lipid metabolic processes involve many molecules; however, the key factors that are sensitive to PCB exposure have not been fully clarified. Here, we summarize the recent developments in PCB research with a focus on biomarkers of lipid metabolic disorders related to environmental exposures.
Search for pair production of scalar top quarks in jets and missing transverse energy channel with the D0 detector

This dissertation describes a search for the pair production of scalar top quarks, {tilde t}{sub 1}, using a luminosity of 995 pb{sup -1} of data collected in p{bar p} collisions with the D0 detector at the Fermilab Tevatron Collider at a center-of-mass energy {radical}s = 1.96 TeV. Both scalar top quarks are assumed to decay into a charm quark and a neutralino, {tilde {chi}}{sub 1}{sup 0}, where {tilde {chi}}{sub 1}{sup 0} is the lightest supersymmetric particle. This leads to a final state with two acoplanar charm jets and missing transverse energy. The yield of such events in data is found to be consistent with the expectations from known standard model processes. Sets of {tilde t}{sub 1} and {tilde {chi}}{sub 1}{sup 0} masses are excluded at the 95% confidence level that substantially extend the domain excluded by previous searches. With the theoretical uncertainty on the {tilde t}{sub 1} pair production cross section taken into account, the largest limit for m{sub {tilde t}{sub 1}} is m{sub {tilde t}{sub 1}} > 150 GeV, for m{sub {tilde {chi}}{sub 1}{sup 0}} = 65 GeV.
Suppression of the metal-insulator transition temperature in thin La0.7Sr0.3MnO3 films

In this paper, we illustrate an approach to discriminate between epitaxial strain and other factors responsible for the decrease of the metal–insulator transition temperature (TP) in thin La0.7Sr0. 3MnO3 films grown by pulsed laser deposition. Using this approach, we have estimated the effect of the biaxial strain on TP. Ultrathin films, independent of epitaxial strain, do not show any metal–insulator transition over the full temperature range. This finding confirms the existence of an interface dead layer. The strain-independent decrease in TP, relative to its bulk value, observed for a much wider thickness range (up to about 1000A) can most likely be attributed to oxygen deficiency.
Evaluation of the absorption ¯ngstr(cid:246)m exponents for traf(cid:2)c and wood burning in the Aethalometer-based source apportionment using radiocarbon measurements of ambient aerosol

Equivalent black carbon (EBC) measured by a multi-wavelength Aethalometer can be apportioned to traf-(cid:2)c and wood burning. The method is based on the differences in the dependence of aerosol absorption on the wavelength of light used to investigate the sample, parameterized by the source-speci(cid:2)c absorption ¯ngstr(cid:246)m exponent ( (cid:11)/ . While the spectral dependence (de(cid:2)ned as (cid:11) values) of the traf(cid:2)c-related EBC light absorption is low, wood smoke particles feature enhanced light absorption in the blue and near ultraviolet. Source apportionment results using this methodology are hence strongly dependent on the (cid:11) values assumed for both types of emissions: traf(cid:2)c (cid:11) TR , and wood burning (cid:11) WB . Most studies use a single (cid:11) TR and (cid:11) WB pair in the Aethalometer model, derived from previous work. However, an accurate determination of the source speci(cid:2)c (cid:11) values is currently lacking and in some recent publications the applicability of the Aethalometer model was questioned. Here we present an indirect methodology for the determination of (cid:11) WB and (cid:11) TR by comparing the source apportionment of EBC using the Aethalometer model with 14 C measurements of the EC fraction on 16 to 40 h (cid:2)lter samples from several locations and campaigns across Switzerland during 2005(cid:150)2012, mainly in winter. The data obtained at eight stations with different source characteristics also en-abled the evaluation of the C measurements are available. However, these results were obtained for locations impacted by black carbon (BC) mainly from traf(cid:2)c consisting of a modern car (cid:3)eet and residential wood combustion with well-constrained combustion ef(cid:2)ciencies. For regions of the world with different combustion conditions, additional BC sources, or fuels used, further investigations are needed.
Progress of effects of 14-3-3 protein on gastric cancer and its mechanism 14-3-3

[Abstract] 14-3-3 proteins are a highly conserved family of cellular proteins, and widely expressed in all eukaryotes. Because they can bind to a variety of functional signal proteins, so be regarded as "bridge proteins" in protein interaction. Studies have shown that the expression level of 14-3-3 protein family in malignant tumors is closely related to tumor size, depth of invasion and metastasis. Some other studies have shown that 14-3-3 protein plays a pivotal role in cell signal transduction, control of cell cycle process and regulation of apoptosis, and plays an important role in the development of gastric cancer, proliferation, invasion, prognosis and drug resistance, so is expected to become a novel therapeutic target for gastric cancer. The present paper aims to expound the role and relevant mechanisms of 14-3-3 protein in gastric cancer.
role individual protein kinase C isoforms in mouse mast cell function their targeting immunomodulatory

ES-62, a glycoprotein secreted by the ﬁlarial nematode Acanthocheilonema viteae , has been shown to modulate the immune system through subversion of signal transduction pathways operating in various immune system cells. With respect to human bone marrow-derived mast cells (BMMCs), ES-62 was previously shown to inhibit Fc (cid:2) RI-mediated mast cell functional responses such as degranulation and pro-inﬂammatory cytokine release through a mechanism involving the degradation of PKC- (cid:2) . At the same time, it was noted that the worm product was able to degrade certain other PKC isoforms but the signiﬁcance of this was uncertain. In this study, we have employed PKC isoform KO mice to investigate the role of PKC- (cid:2) , - (cid:3) - (cid:2) , and - (cid:4) in mouse BMMCs in order to establish their involvement in mast cell-mediated responses and also, if their absence impacts on ES-62’s activity. The data obtained support that in response to antigen cross-linking of IgE bound to Fc (cid:2) RI, pro-inﬂammatory cytokine release is controlled in part by a partnership between one conventional and one novel isoform with PKC- (cid:2) and - (cid:4) acting as positive regulators of IL-6 and TNF- (cid:2) production, while PKC- (cid:3) and (cid:2) act as negative regulators of such cytokines. Furthermore, ES-62 appears to target certain other PKC isoforms in addition to PKC- (cid:2) to inhibit cytokine release and this may enable it to more efﬁciently inhibit mast cell responses.
EM-SHRJ190045 187..188

E mployee engagement has been getting the attention of academia and practitioners, alike, for the past two decades. More so, in the recent past, employee engagement has been listed as one of the top three priorities of HR practitioners across the world. There is a general agreement among HR managers that an engaged employee expends significant amount of discretionary efforts towards organization’s growth and therefore is critical for organizations performance and success, compared to someone who is just “getting-by”.
COMPARATIVE ASSAY OF CIPROFLOXACIN AND DOXYCYCLINE BRANDS MARKETED IN PORT HARCOURT METROPOLIS NIGERIA AGAINST Staphylococcus aureus CLINICAL ISOLATE

Staphylococcus aureus is among the most prominent causes of bacterial infections and because of its unique nature, it can quickly respond to new antibiotic with the development of efficient mechanisms to neutralize them. Undoubtedly, this has left fewer effective drugs to treat these often-life-threatening infections. The aim of this study was to evaluate the potency of ciprofloxacin and doxycycline brands marketed within Port Harcourt Metropolis against Staphylococcus aureus clinical isolate obtained from the Department of Microbiology University of Port Harcourt Teaching Hospital, Nigeria. The minimum inhibitory, sub inhibitory and bactericidal concentrations (MIC, MBC) of the test antibiotics were determined using standard methods. The MIC range for ciprofloxacin was 0.01953125 - 0.065104166 mg/ml, ½ × MIC, 0.009765625 - 0.032552066 mg/ml, 2 × MIC, 0.0390625 - 0.130208333 mg/ml and MBC 0.625-2.5 mg/ml. The MIC results for doxycycline ranged from 0.000325521 - 0.026041666 mg/ml, ½ × MIC 0.00016276 - 0.013020833 mg/ml, 2 × MIC 0.000651042 -0.05208333 and MBC 0.078125 - 0.3125 mg/ml. In this study, sensitivity and effectiveness of doxycycline is higher than that of ciprofloxacin. The different brands showed variation in their sensitivity and effectiveness against the test microorganism. This disparity may be attributed to several factors including pharmacological variability between drug batches or between generic and originator drugs, incorrect drug quantity and presence of impurities, acquisition of resistance through mutations in some of their genes when they are exposed to an antibiotic. A concerted effort is required to ensure that only medicines of acceptable quality reach the end user.
Data Acquisition and Control of Microgrid Using ZigBee – A senior design project

—This paper describes a novel switching mechanism to acquire data and control a microgrid. The grid operates in two distinct modes; Islanding and grid-connected modes. In islanding mode, the circuit should be able to isolate sections of the grid when the electrical grid experiences failure. In grid-connected mode, the microgrid has to supply and maintain the power balance to critical loads. Solar panels act as one of the Distributed energy resource (DER). Batteries are also used as an energy source when grid power is and the DER’s are unable to supply the necessary power for critical loads. The switching is all be automatic with LabVIEW controls, and the ZigBee sensors will remain powered even if grid power is lost in order to complete switching. The concept of acquiring data from ZigBee sensors and switching mechanisms using MOSFETs to control the network are described in this paper.
Neuroﬁbromin (Nf1) is required for skeletal muscle development

Neuroﬁbromatosis type 1 (NF1) is a multi-system disease caused by mutations in the NF1 gene encoding a Ras-GAP protein, neuroﬁbromin, which negatively regulates Ras signaling. Besides neuroectodermal malfor-mations and tumors, the skeletal system is often affected (e.g. scoliosis and long bone dysplasia) demon-strating the importance of neuroﬁbromin for development and maintenance of the musculoskeletal system. Here, we focus on the role of neuroﬁbromin in skeletal muscle development. Nf1 gene inactivation in the early limb bud mesenchyme using Prx1-cre (Nf1 Prx1 ) resulted in muscle dystrophy characterized by ﬁbrosis, reduced number of muscle ﬁbers and reduced muscle force. This was caused by an early defect in myogenesis affecting the terminal differentiation of myoblasts between E12.5 and E14.5. In parallel, the muscle connective tissue cells exhibited increased proliferation at E14.5 and an increase in the amount of connective tissue as early as E16.5. These changes were accompanied by excessive mitogen-activated protein kinase pathway activation. Satellite cells isolated from Nf1 Prx1 mice showed normal self-renewal, but their differentiation was impaired as indicated by diminished myotube formation. Our results demon-strate a requirement of neuroﬁbromin for muscle formation and maintenance. This previously unrecognized function of neuroﬁbromin may contribute to the musculoskeletal problems in NF1 patients.