Miracle-dz/UniFAR-FTUs huggingface dataset:
A population-based study in synchronous versus metachronous metastatic esophagogastric adenocarcinoma

Background: Real-world data on treatment and outcomes in patients with synchronous metastatic disease compared with patients with metachronous metastatic disease in esophagogastric cancer have not been published before. The aim of our study was to explore treatment, overall survival (OS), and time to treatment fialure (TTF) in patients with synchronous and metachronous metastatic esophagogastric adenocarcinoma. Methods: Patients with synchronous metastatic disease (2015–2017) and patients with metachronous metastatic disease initially treated with curative intent for nonmetastatic disease (2015–2016) were selected from the Netherlands Cancer Registry. OS and TTF were assessed from metastatic diagnosis for patients with synchronous, early metachronous (⩽6 months) or late metachronous (>6 months) metastatic disease using Kaplan–Meier curves with two-sided log-rank test. Results: Median OS was 4.2, 2.1, and 4.4 months in patients with synchronous, early metachronous, and late metachronous metastatic disease, respectively (p < 0.001). The proportion of patients receiving systemic treatment was 41.3%, 21.5%, and 32.5% for synchronous, early metachronous, and late metachronous metastatic disease, respectively (p = 0.001). Among patients receiving systemic treatment, median OS was 8.8, 4.5, and 9.1 months (p < 0.001) and median TTF was 6.1, 3.8, and 5.7 months (p < 0.001) in synchronous, early metachronous, and late metachronous metastatic disease, respectively. Conclusion: Patients with early metachronous metastatic disease have a worse survival compared with patients with synchronous or late metachronous metastatic disease. These patients less often receive systemic treatment, and even when treated, survival is worse compared with patients with synchronous or late metachronous metastatic disease, suggesting a more aggressive tumor behavior.
Almost Optimal Construction of Functional Batch Codes Using Extended Simplex Codes

A <italic>functional</italic> <inline-formula> <tex-math notation="LaTeX">$k$ </tex-math></inline-formula><italic>-batch</italic> code of dimension <inline-formula> <tex-math notation="LaTeX">$s$ </tex-math></inline-formula> consists of <inline-formula> <tex-math notation="LaTeX">$n$ </tex-math></inline-formula> servers storing linear combinations of <inline-formula> <tex-math notation="LaTeX">$s$ </tex-math></inline-formula> linearly independent information bits. Any multiset request of size <inline-formula> <tex-math notation="LaTeX">$k$ </tex-math></inline-formula> of linear combinations (or requests) of the information bits can be recovered by <inline-formula> <tex-math notation="LaTeX">$k$ </tex-math></inline-formula> disjoint subsets of the servers. The goal under this paradigm is to find the minimum number of servers for given values of <inline-formula> <tex-math notation="LaTeX">$s$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$k$ </tex-math></inline-formula>. A recent conjecture states that for any <inline-formula> <tex-math notation="LaTeX">$k=2^{s-1}$ </tex-math></inline-formula> requests the optimal solution requires <inline-formula> <tex-math notation="LaTeX">$2^{s}-1$ </tex-math></inline-formula> servers. This conjecture is verified for <inline-formula> <tex-math notation="LaTeX">$s \leqslant 5$ </tex-math></inline-formula> but previous work could only show that codes with <inline-formula> <tex-math notation="LaTeX">$n=2^{s}-1$ </tex-math></inline-formula> servers can support a solution for <inline-formula> <tex-math notation="LaTeX">$k=2^{s-2} + 2^{s-4} + \left \lfloor{ \frac { 2^{s/2}}{\sqrt {24}} }\right \rfloor $ </tex-math></inline-formula> requests. This paper reduces this gap and shows the existence of codes for <inline-formula> <tex-math notation="LaTeX">$k=\lfloor \frac {5}{6}2^{s-1} \rfloor - s$ </tex-math></inline-formula> requests with the same number of servers. Another construction in the paper provides a code with <inline-formula> <tex-math notation="LaTeX">$n=2^{s+1}-2$ </tex-math></inline-formula> servers and <inline-formula> <tex-math notation="LaTeX">$k=2^{s}$ </tex-math></inline-formula> requests, which is an optimal result. These constructions are mainly based on extended Simplex codes and equivalently provide constructions for <italic>parallel Random I/O (RIO)</italic> codes.
Current Collision Mitigation Technologies for Advanced Driver Assistance Systems â€“ A Survey

Road accidents remain a major cause for fatalities globally. A lot of researches have been done and it is widely reported that vehicle automation can reduce human errors, thus reducing road fatalities. The construction of a fully autonomous vehicle is among the major developments of vehicle automation. Many surveys have been done about vehicle automation and Advanced Driver Assistance Systems (ADAS) is one of the fundamental features of a fully autonomous vehicle. Main ADAS features include Automatic Cruise Control, Automatic Parking, Collision Avoidance as well as Lane Departure Warning systems. In this paper, current advances of collision mitigation technologies for ADAS are reviewed as an introductory idea for researchers and general audiences who are new to this field. Each of the systems are discussed in their own sections. The highlights and future directions for each system are brought to light. Several future work suggestions for a comprehensive ADAS systems are highlighted. As this work is intended as a general survey on ADAS, the technical specifications of each system are not discussed in details.
Phenotype and Genotype Interaction Underlying Distributive Characteristic for Awn Development in Rice

As a wild ancestor of cultivated rice, Oryza rufipogon is domesticated into cultivated rice Oryza sativa, many agricultural traits are newly created or disappear. In particular, in wild rice, awn protects from predators and is easily blown by the wind and used as a means of propagation. However, awns gradually disappeared as they were breeding from wild rice to cultivated rice. Since awn development is disadvantageous to rice yield, it is important to understand the genetic basis related to awn development. In addition, characterization of the genes associated with awn development is helpful in analyzing the genetic relationships of rice from ancient times to the present for the regulatory mechanisms of awn formation. QTL analysis identified RM14330-RM218 on chromosome 3 using a 120 Cheongcheong/Nagdong double haploid population. Through screening of genes related to awn development in RM-14330-RM218, it is indicated that OsDRPq3 is a causal gene that can be involved in awn development. OsDRPq3 transcription level is maintained high in long awn and less yield populations during the panicle formation stage, the period during awn development. Moreover, the sequence of OsDRPq3 has high homology with the drooping protein leaf. This study provides a new resource for phylogenetic research of rice and exploration of awn development.
Methylprednisolone and Hyaluronic Acid versus Each Agent Alone to Control Complication of Impacted Wisdom Removal

Introduction Extraction of impacted molars is commonest operation in oral cavity and associated with complications disturbing patient's quality of life. Hyaluronic acid is a nontoxic agent recommended for wound management due to its anti-inflammatory effects. Also, methylprednisolone sodium is used to reduce pain and edema. The aim this study was to compare the effect of combined use of corticosteroid and hyaluronic acid versus each agent alone in controlling postextraction complications of impacted mandibular third molars. Materials and Methods This prospective randomized trial included patients suffering from impacted mandibular third molar. Patients were divided into four groups. Group I, control, and group II received methylprednisolone sodium succinate injection preoperatively, group III received hyaluronic acid applied in extraction socket, and group IV received preoperative methylprednisolone sodium succinate injection and topical hyaluronic acid in the socket. All patients were evaluated preoperatively and postoperative day to assess swelling, pain, mouth opening, and total analgesic dose. Results Group IV showed insignificant edema along the study period, and other groups showed significant edema on third postoperative day that improved on seventh postoperative in group II and III and tenth postoperative day in group I. Significant decreased mouth opening occurred on second postoperative day in group I, while in other groups, it occurred in third postoperative day. Significant improvement occurred on seventh postoperative day in all groups except in group I which occurred on tenth postoperative day. There was less pain and analgesic dose reported in group IV than other groups. Conclusion Combined use of methylprednisolone sodium succinate and hyaluronic acid significantly decrease postoperative complications than using each agent alone.
When We’re Asked to Change: The Role of Suppression and Reappraisal in Partner Change Outcomes

Receiving a request to change from a romantic partner can evoke intense emotional responses that hinder change progress and conflict resolution. As such, investigating how those being asked to change (i.e., change targets) regulate their emotions through key intrapersonal strategies (i.e., suppression and reappraisal) will lend crucial insight into promoting change success. Utilizing laboratory-interaction (Study 1; N = 111 couples) and experience-sampling methods (Study 2; N = 2178 weekly reports from an 8-week diary), we assessed targets’ regulation strategies, change progress, and the extent to which they met their partner’s ideals. Preregistered analyses demonstrated that targets’ use of suppression was not linked to better or worse change outcomes. However, targets’ use of reappraisal was linked to better change outcomes as rated by both partners. Additional analyses revealed that targets’ suppression was linked to targets meeting their partner’s ideals more in the short term but less over time, whereas targets’ reappraisal was linked to targets meeting their partner’s ideals more in both the short term and over time. These findings highlight reappraisal as a key strategy for promoting successful partner change.
Design of a Workstation for People with Upper-Limb Disabilities Using a Brain Computer Interface

This paper shows the design of work-station for work-related inclusion people upper-limb disability. The system involves the use of novel brain computer interface used to bridge the user-computer interaction. Our hope objective is elucidating functional, technological, ergonomic and procedural aspects to runaway operation station; with propose to scratch barrier to impossibility access to TIC’s tools and work done for individual disability person. We found access facility ergonomics, adaptability and portable issue of workstation are most important design criteria. Prototype implementations in workplace environment have TIR estimate of 43% for retrieve. Finally we list a typology of services that could be the most appropriate for the process of labor including: telemarketing, telesales, telephone surveys, order taking, social assistance in disasters, general information and inquiries, reservations at tourist sites, technical support, emergency, online support and after-sales services.
Temperature Changes during Implant Osteotomy Preparations in Fresh Human Cadaver Tibiae, Comparing Straight with Tapered Drills

The success of osseointegration depends on many factors. With temperatures beyond a 47 °C threshold over 1 min, bone survival may be impaired. The purpose of the study was to evaluate, in fresh human cadaver tibiae, the temperature changes during osteotomy preparations using two straight and two tapered implant systems’ drills, external irrigation, and varying revolutions per minute (RPM). The tibiae from a fresh female cadaver were harvested bilaterally. Two tapered and two straight design drills were assessed. Two-hundred and forty osteotomies were prepared at 6 mm depth following the drill sequence of the manufacturers’ protocol for each drilling speed. Difference in temperature (ΔΤ) was calculated by subtracting the baseline from the maximum temperature (ΔT = Tmax − Tbase). Drill design and drill diameter, as independent variables or synergistically, had a significant effect on ΔΤ. Tapered drills: As the drill diameter increased, ΔΤ increased at all RPM. Straight drills: As the drill diameter increased, ΔΤ remained constant or slightly decreased at all RPM. Drill diameter and design had a significant effect on ΔΤ in human tibiae, which never exceeded the critical threshold of 47 °C. Tapered drills caused significantly greater heat production compared to straight drills.
Spectral Vacancy Prediction Using Time Series Forecasting for Cognitive Radio Applications

An identification of unfilled primary user spectrum using a novel method is presented in this paper. Cooperation among users with the utilization of machine learning methods is analyzed. Learning methods are applied to construct the classifier, which selects the suitable fusion algorithm for the considered environment so that the out of band sensing is performed efficiently. Sensing performance is looked into with the existence of fading and it is observed that sensing performance degrades with fading which coincides with earlier findings. From the simulation, it can be inferred that Weibull fading outperforms all the other fading models considered. To accomplish missed detection probability of 1% in the Rayleigh channel, the false alarm probability obtained is almost 0.8 however to obtain the same missed detection probability in the Weibull channel, false alarm probability is less than 0.1 which is very favorable for both indoor and outdoor scenarios. Numerical analyses are carried out here to predict Primary User (PU) channel condition using Hidden Markov Model with the help of Time series forecasting learning method. It is evident that the prediction performance has reached 100% as the result of using the Weibull Fading Model for a period of 200 ms when compared to the Rayleigh model which is achieving only 84.5% accuracy in prediction.
Anti-Depressant Properties of Crocin Molecules in Saffron

Saffron is a valued herb, obtained from the stigmas of the C. sativus Linn (Iridaceae), with therapeutic effects. It has been described in pharmacopoeias to be variously acting, including as an anti-depressant, anti-carcinogen, and stimulant agent. The therapeutic effects of saffron are harbored in its bioactive molecules, notably crocins, the subject of this paper. Crocins have been demonstrated to act as a monoamine oxidase type A and B inhibitor. Furthermore, saffron petal extracts have experimentally been shown to impact contractile response in electrical field stimulation. Other research suggests that saffron also inhibits the reuptake of monoamines, exhibits N-methyl-d-aspartate antagonism, and improves brain-derived neurotrophic factor signaling. A host of experimental studies found saffron/crocin to be similarly effective as fluoxetine and imipramine in the treatment of depression disorders. Saffron and crocins propose a natural solution to combat depressive disorders. However, some hurdles, such as stability and delivery, need to be overcome.
A narrative review of research advances in the study of molecular markers of airway smooth muscle cells

Background and Objective Airway smooth muscle cells (ASMCs) are an important component of the airway. Their thickening and proliferation are important in pathological situations, such as airway remodeling in asthma, but their origin remains unclear. Therefore, characterizing molecular markers of ASMCs were sought to identify the source of increased ASMCs in asthmatic airway remodeling. Methods Articles for this review were derived from a review of the literature related to surface markers and biological properties of ASMCs and smooth muscle cells (SMCs) using PubMed, Google Scholar, and Web of Science. Key Content and Findings This review discusses several SMC molecular markers, describes the different developmental stages of SMCs that express different molecular markers, and summarizes several classical SMC molecular markers. However, the establishment of a specific molecular marker detection system for ASMCs still faces great challenges. Conclusions Although there is no recognized molecular marker detection system for ASMCs, and the study of the properties and sources of increased ASMCs in asthma airway remodeling is still in a state of exploration, the future is promising. Among the SMC markers described in this review, Myosin heavy chain 11 (MYH11) is a molecular marker for mature SMCs and Transgelin (TAGLN) is an early marker for SMC differentiation, and different molecular markers or combinations of molecular markers can be selected for the identification of the properties and sources of increased ASMCs in asthma airway remodeling according to the differentiation period and research needs.
Cognitive style, motivation and learning in inquiry-based early-years science activities

ABSTRACT Cognitive style differences, also known as ‘empathizing’ and ‘systemizing’ have been argued as one reason that may explain differences in children’s motivation to learn science. Researchers claim that people with a ‘systemizing’ cognitive style are likelier to engage in science than those with an ‘empathizing’ cognitive style. As such, they propose tailor-made teaching approaches and themes to specifically motivate children with an ‘empathizing’ cognitive style. In the present study, we introduce structured inquiry-based science activities to children of both cognitive styles and explore whether there is a correlation between cognitive style and engagement, as well as cognitive style and learning outcomes. The main features of this specific learning approach include building knowledge through experiments and investigations, engaging children in problem-solving situations, giving them opportunities to form coherent arguments and test their own spontaneous ideas, draw conclusions, and reflect. The results revealed no statistically significant correlation between the children’s cognitive style and their level of engagement or learning outcomes. The findings suggest that an inquiry-based approach with the above characteristics may be suitable for encouraging science learning and motivation in young children of all cognitive styles.
Success factors for managing the SSBI challenges of the AQUIRE framework

ABSTRACT Self-service business intelligence (SSBI) enables all users, including those with limited technical skills, to perform business intelligence (BI) tasks without the support of BI experts. SSBI reduces pressure on BI experts, gives more freedom to self-reliant users and speeds up decision-making. Recent research has illustrated how organisations experience numerous challenges when trying to obtain SSBI benefits. The AQUIRE framework organises 37 identified SSBI challenges in five categories: A ccess and use of data, Data Q uality, U ser I ndependence, creating R eports and E ducation. SSBI literature does poorly address how these challenges can be tackled. This research study aimed to identify strategies on how to manage those 37 SSBI challenges. The performed case study includes 24 semi-structured interviews with respondents from two organisations which have been heavily involved in SSBI implementation. The results reveal how nine identified SSBI success factors are related to the 37 AQUIRE challenges and how they can be addressed over time.
Comparison of Magnetic Resonance Imaging and Ultrasonography in Tumor Size: Evaluation of Equality in Advanced Cervical Cancer Patients

Background: Cervical cancer is the fourth most common cancer among women worldwide. In Indonesia, cervical cancer is the second most frequent disease related to cancer. Based on staging system criteria, clinical findings are the main criteria to determine cervical cancer stage. In the revised version of the Federation of Gynecology and Obstetrics staging system criteria for cervical cancer, radiological examination for pretreatment evaluation in gynecological malignancies has been used in routine modalities. Magnetic resonance imaging (MRI) and ultrasonography (USG) are commonly used in the presurgery determination of tumor size and the follow-up of cervical cancer patients. Tumor size determines cancer stage which influences the treatment and the survival. The equality of diagnostic accuracy was compared for MRI and ultrasound in this study for tumor size evaluation of cervical cancer patients. Methods: This was a prospective study including 195 patients with cervical cancer Stage IIIB in Dr. Cipto Mangunkusumo Hospital from 2016 to 2018. The tumor sizes and stages of cervical cancer were assessed on MRI and ultrasound. This study evaluated diagnostic accuracy between MRI and US. The sensitivity and specificity were compared by using McNemar test. Results: The result of the study showed that from 195 patients, 76 patients fulfilled the study inclusion criteria. There is a significant difference in assessing tumor size in cervical cancer patients between ultrasound and MRI (mean, 1.72 cm; P < 0.0001). US had 82% sensitivity, 88% specificity, and 82% diagnostic accuracy (P = 0.003, McNemar test). Conclusion: Ultrasound examination showed a comparable accuracy to MRI for assessing tumor size in cervical cancer. US is an affordable and feasible diagnostic staging tool with accuracy comparable to MRI.
Hemicellulose and Nano/Microfibrils Improving the Pliability and Hydrophobic Properties of Cellulose Film by Interstitial Filling and Forming Micro/Nanostructure

In this paper, nano/microfibrils were applied to enhance the mechanical and hydrophobic properties of the sugarcane bagasse fiber films. The successful preparation of nano/microfibrils was confirmed by scanning electron microscope (SEM), X-ray diffraction (XRD), fiber length analyzer (FLA), and ion chromatography (IC). The transparency, morphology, mechanical and hydrophobic properties of the cellulose films were evaluated. The results show that the nanoparticle was formed by the hemicellulose diffusing on the surface of the cellulose and agglomerating in the film-forming process at 40 °C. The elastic modulus of the cellulose film was as high as 4140.60 MPa, and the water contact angle was increased to 113°. The micro/nanostructures were formed due to hemicellulose adsorption on nano/microfilament surfaces. The hydrophobicity of the films was improved. The directional crystallization of nano/microfibrous molecules was found. Cellulose films with a high elastic modulus and high elasticity were obtained. It provides theoretical support for the preparation of high-performance cellulose film.
Migrant Smuggling to Europe: A Matching Model

This paper develops a matching model à la Pissarides (2000) to analyze the migrant smuggling market, building on the empirical evidence related to the smuggling of migrants from the Horn of Africa and the Middle East to the European region in the last decade. The model allows us to determine the equilibrium numbers of smugglers and of incoming irregular migrants as well as the total migrant welfare. Most of the coercion-based measures targeting the smugglers achieve the reduction in the number of irregular migrants and smugglers at the expense of migrants’ overall welfare. Slightly increasing legal migration opportunities has the interesting feature of drastically reducing irregular flows, without deteriorating migrants’ welfare nor increasing the total number of migrants. The model reveals that an extremely restrictive asylum policy has similar effects in terms of the flows of irregular migrants as a quite loose one, with the largest flows of irregular migrants reached for a "middle-range" policy. Finally, the stay-home incentive of generous humanitarian policies might be partially offset by higher profits and a higher smuggling activity.