Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of combined paracetamol and dexamethasone vs. paracetamol on postoperative nausea vomiting after cesarean section

Abstract Objectives Postoperative nausea and vomiting (PONV) are common symptoms after cesarean delivery (CD) that affect patients outcomes and satisfaction. The treatment of choice is still evolving, therefore, we aimed to evaluate PONV of combined paracetamol-dexamethasone vs. paracetamol alone. Methods This study is a double-blind randomized controlled trial on 100 patients undergoing cesarean delivery. Participants were randomly assigned into two groups of paracetamol or combined paracetamol-dexamethasone. Nausea and vomiting score, VAS score of pain, and chill were compared between the two groups. Results The result of this study found that mild nausea 2nd h after surgery in the combined group was lesser than paracetamol group (0.03). However, there was no statistically significant difference in nausea and vomiting score in other periods of time between the two groups. VAS score of pain decreased 12th and 6th h after the surgery in the combined and paracetamol group, respectively. Chilling occurred in two patients of combined group and four patients of paracetamol group (p=0.432). Conclusions Dexamethasone added to paracetamol might not improve pain and vomiting after cesarean delivery comparison with just paracetamol. But it can be effective for reducing the score of nausea after the surgery.
HR-VEAW: A Human Rights Violation Exploration Analytics, and Warning System

The availability of information from social media, such as tweets, and human rights monitors, such as Amnesty International, Human Rights Watch, and the US State Department has led to new opportunities to measure repression and human rights protections in higher resolution. In this paper, we present HR-VEAW, a Human Rights Violation Exploration, Analytics, and Warning system, to support understanding of social conflict dynamics and human rights violations/protections with quantitative data. After briefly discussing HR-VEAW’s data acquisition and analysis components, we demonstrate how it visualizes rich spatio-temporal and conceptual information, enabling the examination of changes in patterns of violation and protection in aggregate over time, or across both space and time. This way HR-VEAW helps to explain social instability and conflicts and to guide decision-making, theorizing, and predictions.
AI Courses for Secondary and High School - Comparative Analysis and Conclusions

The paper discusses some ideas underlying the vision for Bulgaria to become a regional centre for education and research in the field of artificial intelligence in the coming years, outlined in several national strategic documents. Special attention is paid to a number of issues related to the creation of appropriate high school curricula, related to artificial intelligence. A comparative analysis of existing artificial intelligence courses suitable for secondary and high school students has been presented and corresponding conclusions and recommendations have been formulated
On Identifying Similar User Stories to Support Agile Estimation based on Historical Data

Accurate and reliable effort and cost estimation is still a challenging activity for agile teams. It is argued that leveraging historical data regarding the actual time spent on similar past projects could be very helpful to support such an activity before companies can embark upon a new project. In this position paper, we discuss our initial efforts towards a software tool that retrieves similar user stories from a database of past projects to support developers estimating effort and cost of developing similar new projects. In close collaboration with a Danish software development company, we developed a tool that employs Natural Language Processing (NLP) algorithms to find past similar user stories and retrieve the actual time spent on them. Developers can then make use of the actual implementation time of these stories as the new estimate or use the value to support their decision on a different estimate. Results of a preliminary evaluation regarding the performance of such a tool in terms of precision and recall showed that it is capable of finding similar stories fairly well, but also showed that different phrasings and wordings can have a high impact on similarity scores.
Anatomy and Function of Ventral Tegmental Area Glutamate Neurons

The ventral tegmental area (VTA) is well known for regulating reward consumption, learning, memory, and addiction behaviors through mediating dopamine (DA) release in downstream regions. Other than DA neurons, the VTA is known to be heterogeneous and contains other types of neurons, including glutamate neurons. In contrast to the well-studied and established functions of DA neurons, the role of VTA glutamate neurons is understudied, presumably due to their relatively small quantity and a lack of effective means to study them. Yet, emerging studies have begun to reveal the importance of glutamate release from VTA neurons in regulating diverse behavioral repertoire through a complex intra-VTA and long-range neuronal network. In this review, we summarize the features of VTA glutamate neurons from three perspectives, namely, cellular properties, neural connections, and behavioral functions. Delineation of VTA glutamatergic pathways and their interactions with VTA DA neurons in regulating behaviors may reveal previously unappreciated functions of the VTA in other physiological processes.
The Genetic Spectrum of Familial Hypertriglyceridemia in Oman

Familial hypertriglyceridemia (F-HTG) is an autosomal disorder that causes severe elevation of serum triglyceride levels. It is caused by genetic alterations in LPL, APOC2, APOA5, LMF1, and GPIHBP1 genes. The mutation spectrum of F-HTG in Arabic populations is limited. Here, we report the genetic spectrum of six families of F-HTG of Arab ancestry in Oman. Methods: six Omani families affected with triglyceride levels >11.2 mmol/L were included in this study. Ampli-Seq sequencing of the selected gene panels was performed. Whole-exome sequencing and copy number variant analysis were also performed in cases with negative exome results. Three novel pathogenic missense variants in the LPL gene were identified, p.M328T, p.H229L, and p.S286G, along with a novel splice variant c.1322+15T > G. The LPL p.H229L variant existed in double heterozygous mutation with the APOA5 gene p.V153M variant. One family had a homozygous mutation in the LMF1 gene (c.G107A; p.G36D) and a heterozygous mutation in the LPL gene (c.G106A; p.D36N). All affected subjects did not have a serum deficiency of LPL protein. Genetic analysis in one family did not show any pathogenic variants even after whole-exome sequencing. These novel LPL and APOA5 mutations are not reported in other ethnic groups. This suggests that patients with F-HTG in Oman have a founder effect and are genetically unique. This warrants further analysis of patients of F-HTG in the Middle East for preventative and counseling purposes to limit the spread of the disease in a population of high consanguinity.
Prevalence of Mycoplasma bovis in Algeria and Characterisation of the Isolated Clones

Bovine respiratory disease (BRD) is common in calves in Algeria, but to date, Mycoplasma bovis has never been monitored as a potential etiological agent. Here, to assess the presence (direct detection) and circulation (indirect detection) of M. bovis, broncho-alveolar lavage fluids (BALF) and serum samples were collected from 60 veal calf farms in Algeria. A commercial ELISA kit (ID Screen® ELISA) was used to screen for the presence of specific antibodies against M. bovis in 351 blood sera collected from both diseased and healthy calves, and 69% (241 sera) tested positive. BALFs from the 176 diseased calves were used to screen for M. bovis by real-time-PCR (rt-PCR), and 102 (58%) tested positive. A non-exhaustive set of 53 clones were isolated from 44 calves and further subtyped using polC gene sequencing. No predominant subtype was found, and two clones exhibited a new subtype. Fourteen clones were further characterized by multilocus sequence typing, and results showed a high degree of genetic diversity, with some clones having new alleles and subtypes. The minimum inhibitory concentrations (MICs) of 5 antimicrobials regularly used to treat BRD was determined on 45 clones. Susceptibility profiles showed very broad diversity, confirming the variety of clones actively circulating. We detected clones with high MICs, including increased MICs of enrofloxacin (n = 5). This is the first study to report the presence of M. bovis in Algeria in calves with BRD. This research also finds broad genetic and phenotypic diversity in the actively circulating isolates.
Effect of Matching Between the Adopted Corporate Response Strategy and the Type of Hypocrisy Manifestation on Consumer Behavior: Mediating Role of Negative Emotions

Consumers may sense hypocrisy in corporate social responsibility (CSR) if they note inconsistency in enterprises’ words and deeds related to CSR. This inconsistency originates from the intentional selfish actions and unintentional actions of enterprises. Studies have revealed that consumers’ perception of hypocrisy has a negative influence on enterprise operation. However, studies have not examined how corporate responses to consumers’ hypocrisy perception affect consumers’ attitude and behavior. Therefore, the present study attempted to determine the measures that should be undertaken by enterprises to reduce consumers’ negative response to them when consumers perceive them to be hypocritical. We conducted a situational simulation experiment to explore the effect of the match between corporate hypocrisy manifestation (moral hypocrisy vs. behavioral hypocrisy) and the corporate response strategy (reactive CSR communication vs. proactive CSR communication) on consumers’ negative behaviors toward an enterprise and to test the mechanism influencing this effect. The results indicated that the interaction between the type of corporate hypocrisy and the corporate response strategy has a significant effect on consumers’ negative behaviors toward an enterprise. Consumers’ negative emotions have a mediating influence on the aforementioned effect. This study explored the response strategies of enterprises during a corporate hypocrisy crisis, classified corporate hypocrisy crises into two types (moral hypocrisy vs. behavioral hypocrisy) according to the different manifestations of corporate hypocrisy, and introduced situational crisis communication theory (SCCT) into research on corporate hypocrisy. The present results help expand knowledge on corporate hypocrisy.
Effects of Galla chinensis Extract on Growth Performance, Carcass Traits, Serum Antioxidation, Immune Function, and Gut Microbiota of Broilers

The purpose of this experiment was to explore the effects of Galla chinensis extract (GCE) supplementation in broiler diets on growth performance, carcass traits, serum antioxidation, immune function, and gut microbiota. In this study, broiler chicken diets were supplemented with a product of GCE at 0 mg/kg (control), 250 mg/kg (GCE250), 500 mg/kg (GCE500), 1,000 mg/kg (GCE1000), or 2,000 mg/kg (GCE2000). In total, 360 birds were randomly distributed into five treatments with six replicate pens and fed from 1 to 60 days. The birds in the GCE250 group had higher final body weights (p < 0.05) compared with the control group. Low-dose supplementation (250 mg/kg) of GCE significantly improved the broiler chicken's antioxidative and anti-inflammatory abilities by decreasing serum levels of malondialdehyde, interleukin 6, and interferon-γ at day 60 (p < 0.05). Additionally, principal coordinate analysis clustering showed that GCE supplementation shifted the cecal microbiota of broiler chickens compared with control at day 60, increasing the relative abundance of beneficial bacterial genera such as Faecalibacterium, Parabacteroides, and Alistipes, and decreasing the potentially pathogenic bacteria Streptococcus. Taken together, the results of this study showed that dietary supplementation of low concentrations of GCE (250 mg/kg) produced a positive influence on growth performance, gut microbiota, serum antioxidation, and anti-inflammatory markers in broiler chickens.
Combating Salinity Through Natural Plant Extracts Based Biostimulants: A Review

Enhanced crop growth and yield are the recurring concerns in agricultural field, considering the soaring world population and climate change. Abiotic stresses are one of the major limiting factors for constraining crop production, for several economically important horticultural crops, and contribute to almost 70% of yield gap. Salt stress is one of these unsought abiotic stresses that has become a consistent problem in agriculture over the past few years. Salinity further induces ionic, osmotic, and oxidative stress that result in various metabolic perturbations (including the generation of reactive oxygen, carbonyl, and nitrogen species), reduction in water potential (ψw), distorted membrane potential, membrane injury, altered rates of photosynthesis, leaf senescence, and reduced nitrogen assimilation, among others); thereby provoking a drastic reduction in crop growth and yield. One of the strategies to mitigate salt stress is the use of natural plant extracts (PEs) instead of chemical fertilizers, thus limiting water, soil, and environmental pollution. PEs mainly consist of seeds, roots, shoots, fruits, flowers, and leaves concentrates employed either individually or in mixtures. Since PEs are usually rich in bioactive compounds (e.g., carotenoids, flavonoids, phenolics, etc.), therefore they are effective in regulating redox metabolism, thereby promoting plant growth and yield. However, various factors like plant growth stage, doses applied, application method, soil, and environmental conditions may greatly influence their impact on plants. PEs have been reported to enhance salt tolerance in plants primarily through modulation of signaling signatures and pathways (e.g., Na+, ANNA4, GIPC, SOS3, and SCaBP8 Ca2+ sensors, etc.), and regulation of redox machinery [e.g., superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), non-specific peroxidase (POX), glutathione peroxidase (GPX), peroxiredoxin (Prx), ascorbic acid (AsA), glutathione (GSH), α-tocopherol, etc.]. The current study highlights the role of PEs in terms of their sources, methods of preparation, and mode of action with subsequent physiological changes induced in plants against salinity. However, an explicit mode of action of PEs remains nebulous, which might be explicated utilizing transcriptomics, proteomics, metabolomics, and bioinformatics approaches. Being ecological and economical, PEs might pave the way for ensuring the food security in this challenging era of climate change.
Application of the Abaqus *Fabric Model to Approximate the Draping Behavior of UD Prepregs Based on Suited Mechanical Characterization

The increasing demand for automated manufacturing processes for carbon fiber-reinforced polymers necessitates accurate forming simulations. For that purpose, the multi-purpose finite element solver Abaqus provides the phenomenological *Fabric material model. While it is designed for woven materials, both structural directions and shear properties can be independently adjusted. We aim to quantify its applicability to model forming of UD semi-finished prepregs in a diaphragm forming station. We describe the material characterization and modeling and compare the simulation results to experiments using accurate laser scans of manufactured parts. Various simulation aspects are methodically altered to better gauge their impact on the simulated forming result. An accurate calibration of the bending behavior was found to be most important for the forming results. This is realized in the *Fabric material model by softening the compressive stiffness and the limitations of this workaround must be investigated in more detail. Other aspects, like rate-dependent modeling of the transverse direction and anisotropic properties for friction should be considered. Overall, a good agreement with experimental results including regions with fiber bridging or the formation of folds and the contour of the part could be achieved.
Oncolytic Adenoviral Vector-Mediated Expression of an Anti-PD-L1-scFv Improves Anti-Tumoral Efficacy in a Melanoma Mouse Model

Oncolytic virotherapy is an emerging therapeutic approach based on replication-competent viruses able to selectively infect and destroy cancer cells, inducing the release of tumor-associated antigens and thereby recruiting immune cells with a subsequent increase in antitumoral immune response. To increase the anticancer activity, we engineered a specific oncolytic adenovirus expressing a single-chain variable fragment of an antibody against PD-L1 to combine blockage of PD-1/PD-L1 interaction with the antitumoral activity of Onc.Ad5. To assess its efficacy, we infected B16.OVA cells, a murine model of melanoma, with Ad5Δ24 -anti-PD-L1-scFv and then co-cultured them with C57BL/6J naïve splenocytes. We observed that the combinatorial treatments were significantly more effective in inducing cancer cell death. Furthermore, we assessed the efficacy of intratumoral administrations of Ad5Δ24-anti-PD-L1-scFv in C57BL/6J mice engrafted with B16.OVA and compared this treatment to that of the parental Ad5Δ24 or placebo. Treatment with the scFv-expressing Onc.Ad induced a marked reduction of tumor growth concerning the parental Onc.Ad. Additionally, the evaluation of the lymphocytic population infiltrating the treated tumor reveals a favorable immune profile with an enhancement of the CD8+ population. These data suggest that Onc.Ad-mediated expression of immune checkpoint inhibitors increases oncolytic virotherapy efficacy and could be an effective and promising tool for cancer treatments, opening a new way into cancer therapy.
Perceptions of Weight Change Among Romantic Partners: Considering Body Image, Relationship Experiences, Gender, and Sexual Orientation

Romantic relationship experiences have been found to be relevant to body image and weight in adulthood. In this study, we investigated predictors of heterosexual, lesbian, and gay romantic partners' (N = 500, Mage = 29.3) perceptions of their own and their partners' weight at the beginning of their relationship and 4.8 years later, on average. Perceived changes in participants' own weight status was associated with greater body dissastisfaction and longer relationship length. Perceived changes in partners' weight status was associated with their partners' BMI, as well as relationship quality. We also found that gender was important in understanding some of these associations. Implications of weight perceptions for individuals' and their partners' health and well-being and the critical role of relationship quality are discussed in the context of the health regulation model.
Cost Function Determination for Human Lifting Motion via the Bilevel Optimization Technology

Investigating the optimal control strategy involved in human lifting motion can provide meritorious insights on designing and controlling wearable robotic devices to release human low-back pain and fatigue. However, determining the latent cost function regarding this motion remains challenging due to the complexities of the human central nervous system. Recently, it has been discovered that the underlying cost function of a biological motion can be identified from an inverse optimization control (IOC) issue, which can be handled via the bilevel optimization technology. Inspired by this discovery, this work is dedicated to studying the underlying cost function of human lifting tasks through the bilevel optimization technology. To this end, a nested bilevel optimization approach is developed by integrating particle swarm optimization (PSO) with the direction collocation (DC) method. The upper level optimizer leverages particle swarm optimization to optimize weighting parameters among different predefined performance criteria in the cost function while minimizing the kinematic error between the experimental data and the result predicted by the lower level optimizer. The lower level optimizer implements the direction collocation method to predict human kinematic and dynamic information based on the human musculoskeletal model inserted into OpenSim. Following after a benchmark study, the developed method is evaluated by experimental tests on different subjects. The experimental results reveal that the proposed method is effective at finding the cost function of human lifting tasks. Thus, the proposed method could be regarded as a paramount alternative in the predictive simulation of human lifting motion.
The Global Burden of Osteoporosis, Low Bone Mass, and Its Related Fracture in 204 Countries and Territories, 1990-2019

Background Low bone mineral density (LBMD), including osteoporosis and low bone mass, has becoming a serious public health concern. We aimed to estimate the disease burden of LBMD and its related fractures in 204 countries and territories over the past 30 years. Methods We collected detailed information and performed a secondary analysis for LBMD and its related fractures from the Global Burden of Disease Study 2019. Numbers and age-standardized rates related to LBMD of disability-adjusted life-years (DALYs) and deaths in 204 countries and territories were compared by age, gender, socio-demographic index (SDI), and location. Results Global deaths and DALYs number attributable to LBMD increased from 207 367 and 8 588 936 in 1990 to 437 884 and 16 647 466 in 2019, with a raise of 111.16% and 93.82%, respectively. DALYs and deaths number of LBMD-related fractures increased 121.07% and 148.65% from 4 436 789 and 121248 in 1990 to 9 808 464 and 301 482 in 2019. In 2019, the five countries with the highest disease burden of DALYs number in LBMD-related fractures were India (2 510 288), China (1 839 375), United States of America (819 445), Japan (323 094), and Germany (297 944), accounting for 25.59%, 18.75%, 8.35%, 3.29%, and 3.04%. There was a quadratic correlation between socio-demographic index (SDI) and burden of LBMD-related fractures: DALYs rate was 179.985-420.435SDI+417.936SDI2(R2 = 0.188, p<0.001); Deaths rate was 7.879-13.416SDI+8.839 SDI2(R2 = 0.101, p<0.001). Conclusions The global burden of DALYs and deaths associated with LBMD and its related fractures has increased significantly since 1990. There were differences in disease burden between regions and countries. These estimations could be useful in priority setting, policy-making, and resource allocation in osteoporosis prevention and treatment.