Miracle-dz/UniFAR-FTUs huggingface dataset:
Motor Cortex Response to Pleasant Odor Perception and Imagery: The Differential Role of Personality Dimensions and Imagery Ability

Background Neuroimaging studies have shown a complex pattern of brain activation during perception of a pleasant odor and during its olfactory imagery. To date, little is known regarding changes in motor cortex excitability during these tasks. Bergamot essential oil (BEO) is extensively used in perfumes and cosmetics for its pleasantness. Therefore, to further our understanding of the human sense of smell, this study aimed to investigate the effect of perception and imagery of a pleasant odor (BEO) on motor cortex using Transcranial magnetic stimulation (TMS). Materials and Methods We examined the primary motor cortex (M1) excitability during perception of a pleasant odor (BEO) or perception of odorless saline (experiment 1). Furthermore, we tested the effect of olfactory imagery (OI) of BEO on corticospinal excitability (experiment 2). The increase in motor evoked potential (MEP) amplitude was correlated with personality dimensions scores, pleasantness, vividness, and general imagery ability. Results The results indicate that the corticospinal excitability changed after both perception and imagery of a pleasant odor (BEO). The correlation analysis shows an association with neuroticism personality trait (experiment 1) and with general olfactory imagery ability (experiment 2). Conclusion Both perception of a pleasant odor and its olfactory imagery modulate motor cortex excitability. The enhanced brain activation is affected by specific individual characteristics. Overall, our findings provide physiological evidence for a complex interaction between the olfactory and motor systems.
Novel Mechanisms for Post-Transplant Maintenance Therapy in Acute Myeloid Leukemia

Allogeneic stem cell transplantation has improved survival for patients with acute myeloid leukemia (AML), especially for patients with disease at high risk of relapse. However, relapse remains the most common cause of treatment failure and death in the post-transplant period. Maintenance therapy, an extended course of treatment after achieving remission to reduce the rate of relapse, is an important component of the treatment of various hematologic malignancies; however, its role in the treatment of AML is far less well-defined. Recently, there has been significant interest in the use of novel therapeutic agents as maintenance therapy after allogeneic stem cell transplant, utilizing new mechanisms of treatment and more favorable toxicity profiles. In this review, we will discuss the mechanistic and clinical data for post-transplant maintenance therapies in AML. Then, we will review several emergent and current clinical trials which aim to incorporate novel agents into maintenance therapy regimens.
Integrative Bioinformatics Analysis Reveals CHEK1 and UBE2C as Luminal A Breast Cancer Subtype Biomarkers

In light of the limited number of targetable oncogenic drivers in breast cancer (BRCA), it is important to identify effective and druggable gene targets for the treatment of this devastating disease. Herein, the GSE102484 dataset containing expression profiling data from 683 BRCA patients was re-analyzed using weighted gene co-expression network analysis (WGCNA). The yellow module with the highest correlation to BRCA progression was screened out, followed by functional enrichment analysis and establishment of a protein–protein interaction (PPI) network. After further validation through survival analysis and expression evaluation, CHEK1 and UBE2C were finally identified as hub genes related to the progression of BRCA, especially the luminal A breast cancer subtype. Notably, both hub genes were found to be dysregulated in multiple types of immune cells and closely correlated with tumor infiltration, as revealed by Tumor Immune Estimation Resource (TIMER) along with other bioinformatic tools. Construction of transcription factors (TF)-hub gene network further confirmed the existence of 11 TFs which could regulate both hub genes simultaneously. Our present study may facilitate the invention of targeted therapeutic drugs and provide novel insights into the understanding of the mechanism beneath the progression of BRCA.
On the partial derivative method applied to lopsided set-multilinear polynomials

We make progress on understanding a lower bound technique that was recently used by the authors to prove the first superpolynomial constant-depth circuit lower bounds against algebraic circuits. More specifically, our previous work applied the well-known partial derivative method in a new setting, that of lopsided set-multilinear polynomials. A set-multilinear polynomial P ∈ F[X1, . , Xd] (for disjoint sets of variables X1, ., Xd) is a linear combination of monomials, each of which contains one variable from X1, . , Xd. A lopsided space of set-multilinear polynomials is one where the sets X1, . , Xd are allowed to have different sizes (we use the adjective "lopsided" to stress this feature). By choosing a suitable lopsided space of polynomials, and using a suitable version of the partial-derivative method for proving lower bounds, we were able to prove constant-depth superpolynomial set-multilinear formula lower bounds even for very low-degree polynomials (as long as d is a growing function of the number of variables N). This in turn implied lower bounds against general formulas of constant-depth. A priori, there is nothing stopping these techniques from giving us lower bounds against algebraic formulas of any depth. We investigate the extent to which this lower bound can extend to greater depths. We prove the following results. 1. We observe that our choice of the lopsided space and the kind of partial-derivative method used can be modeled as the choice of a multiset W ⊆ [−1, 1] of size d. Our first result completely characterizes, for any product-depth Δ, the best lower bound we can prove for set-multilinear formulas of product-depth Δ in terms of some combinatorial properties of W, that we call the depth-Δ tree bias of W. 2. We show that the maximum depth-3 tree bias, over multisets W of size d, is Θ(d1/4). This shows a stronger formula lower bound of Nω(d1/4) for set-multilinear formulas of product-depth 3, and also puts a non-trivial constraint on the best lower bounds we can hope to prove at this depth in this framework (a priori, we could have hoped to prove a lower bound of NΩ(Δd1/Δ) at product-depth Δ). 3. Finally, we show that for small Δ, our proof technique cannot hope to prove lower bounds of the form NΩ(Δd1/ poly(Δ)). This seems to strongly hint that new ideas will be required to prove lower bounds for formulas of unbounded depth.
Speech Research

For the purposes of this survey 'speech research' will be taken to comprise studies of the stages in spoken communication from the phonetic coding and production of an utterance by a speaker, through the acoustic signal which forms the speaker's primary link with the hearer, to its perception and decoding by the hearer. Although studies which have implications uniquely for one stage are perhaps few, work will be presented according to whether its primary concern is with speech production, acoustics, or perception, respectively. Given the size and diversity of the field, drawing contributions from linguists, psychologists, speech pathologists, engineers and others, a survey such as this could never attempt to be comprehensive. Rather, the aim has been to select areas which have been of central interest in speech research, and where significant progress has been made in the past decade. Although the survey is primarily concerned with descriptive and theoretical aspects of speech research, it will also mention selected applications of interest.
Iron Contamination: A Major Threat in Chhattisgarh, India

Due to increase in urbanization, rapid industrialization and lack of proper management, has created a problem such as loss of biodiversity, affected environmental health as well as human health. Among the industry, mining is the prominent one because of a supplier of a raw material for various industries. Due to this ground this region affected more in terms environment as well human health. Chhattisgarh is rich in various kinds of mineral and therefore mining is common here, especially iron mining affected this region much for the environment as well as to animal and human health. Due to the mining activities iron concentration has been increased in the surrounding soil and water and peoples using contaminated water for daily life purpose as well as for crop irrigation, therefore the metal deposited successively to different tropic level. The high concentration of iron into the body can form free radical which can lead to tissue damage and other neurodegenerative disease. Apart from this illness, accident and death of many people’s are commonly observed. Hence an effort has been made to highlight this case study to pay more scientific attention, to find a suitable solution to minimize and resolve the problems.
Engaging Construction Contractors to Identify Barriers and Promising Practices to Reduce the Risk for Occupational Injuries Associated With Manual Materials Handling

Overexertion injuries related to lifting, pushing, pulling, holding, or carrying objects are a leading cause of occupational injury in the construction industry. Although significant research exists on interventions and practices that could reduce the risk for these injuries, adoption by construction employers has been slow. Ergonomics researchers and safety advocates have struggled to effectively promote safer manual materials handling (MMH) in the complex and dynamic environment of construction sites. Our Ergonomics Community of Practice conducted formative research on the extent to which construction contractors are taking action to reduce MMH injuries, the barriers to engaging in safer practices, and how safety-minded contractors successfully overcame common barriers and associated risks on their job sites. These “positive deviants” used similar strategies regardless of their size or trade. Their strategies suggest fresh opportunities for repositioning and promoting safer MMH practices and increasing their use in the construction industry.
CMAR_A_272324 10505..10519

Department of Gastrointestinal Surgery, The Second People’s Hospital of Yibin, Yibin, Sichuan, 644000, People’s Republic of China Background: Cisplatin (CDDP) plays a vital role in the treatment of advanced gastric adenocarcinoma (GAC); however, the development of chemoresistance depletes the overall benefit of CDDP. This study harbored the aim to investigate the role of a novel circular RNA (circRNA), circ_0000260, in DDP-resistant GAC and provide a potential mechanism to explain its function. Methods: The morphology of tumor tissues and normal tissues was observed by hematoxylin-eosin (HE) staining. The isolated exosomes were observed and examined using transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA). The expression of circ_0000260, miR-129-5p and matrix metalloproteinase 11 (MMP11) mRNA was measured by quantitative real-time polymerase chain reaction (qRT-PCR). The protein levels of CD63, CD81, fibronectin, vitronectin and MMP11 were detected by Western blot. Cell viability, colony formation, cell apoptosis, migration, invasion and cell adhesion were monitored by cell counting kit-8 (CCK-8) assay, colony formation assay, flow cytometry assay, scratch assay, transwell assay and cell adhesion assay, respectively. The interaction between miR-129-5p and circ_0000260 or MMP11 predicted by bioinformatics analysis was verified by dual-luciferase reporter assay. Animal experiments were performed in nude mice to explore the role of circ_0000260 in vivo. Results: The expression of circ_0000260 was promoted in tumor tissues and serum-derived exosomes of GAC patients, and circ_0000260 expression in CDDP-resistant tumor tissues was higher than that in CDDP-sensitive tumor tissues. Circ_0000260 knockdown lessened CDDP chemoresistance, suppressed cell proliferation, migration, invasion and adhesion, and induced apoptosis. In mechanism, circ_0000260 regulated the expression of MMP11 by targeting miR-129-5p. MiR-129-5p inhibition could reverse the functions of circ_0000260 knockdown, and MMP11 knockdown could also reverse the effects of miR-129-5p inhibition. Besides, circ_0000260 knockdown attenuated CDDP resistance during tumor growth in vivo by regulating the expression of miR-129-5p and MMP11. Conclusion: Circ_0000260 regulated CDDP chemoresistance of GAC by promoting MMP11 expression via targeting miR-129-5p.
ANATOMICAL, HISTOLOGICAL, AND SCANNING ELECTRON MICROSCOPIC STUDIES OF THE ALIMENTARY CANAL OF LAUDAKIA STELLIO (AGAMIDAE)

: The present work studied the structure of alimentary canal of the lizard Laudakia stellio under the light and scanning electron microscope. The observations revealed that the canal consists of the oral cavity, oesophagus, stomach, small intestine and large intestine. These regions consist of the following layers from outside inwards; serosa, mascularis, submucosa and mucosa. The oesophageal mucosa consists of ciliated columnar epithelium and goblet cells. The gastric mucosa is thrown into folds with brush-border cells and tubular glands are found. The small intestineal mucosa is built up of ciliated columnar epithelium, and the crypts of Lieberkhün are completely absent. The rectal mucosa is represented by columnar epithelium only. SEM examination revealed that the stomach luminal surface exhibits several convolutions of the mucosal layers forming gastric pits and tubular glands. The luminal mucosa of the intestine is composed of elevations occurred at the base of the villi. The villi possess numerous goblet cells. In the rectum, the serosa is followed by a thick muscularis and the submucosa is narrow. The mucosa is in the form of numerous shallow but deeper pits and is devoid of glands.
Vibro- and sound protection in road machines by means of vibration absorbing

In most cases, road machines emit both acoustic and vibration energy into the fluids or structures surrounding the machinery. This is dangerous for the construction strength of the machinery, and is harmful for human health. There are two general classes of tools used to assess and optimize acoustic performance of a vehicle: test based methods, and Computer-Aided Engineering based methods. The second one is discussed in this paper.
Comparing Software Quality Models: An Overview

Software quality models are well-accepted means to support quality management of software systems. Over the last years many quality models are proposed and applied with varying aspects. But quality models are still criticized because of yet to be solved issue of little practical adoption of these models. It is defined and discussed in literature that “what are quality models? ” but the key point is “how can quality models be adopted in practice? ” Software quality models are used to determine the functionality, quality attributes, internal and external characteristics of the system. This paper aims to give the overview of software quality model by answering questions like what are these quality models? , how these can be implemented? and , how these software quality models can be compared? It also highlights the issues and proposed techniques, models and approaches of these models that are identified from literature survey.
Conservation in conversation: People's perspectives on a woodland with high conservation value—A qualitative study

1. Concepts such as ecosystem services and nature's contributions to people are frameworks for articulating the value of nature and biodiversity conservation. Yet it remains difficult to argue for the conservation of species and habitats where they are inconspicuous or ‘non-charismatic’. 2. This paper investigates the perceptions of a woodland area in rural western Scotland, designated for its high conservation value and characterised by habitats, rare species and species assemblages with limited appreciation by non-experts and no obvious ‘utility’ value. Based on interviews with residents and visitors as well as workshops with participants representing different types of local expertise, we show how people experience and perceive the benefits from such woodlands. 3. Overall, our study
A Difference Subgridding Method for Solving Multiscale Electro-Thermal Problems

Because of less memory costs and time consumption, a finite difference subgrid technique can effectively deal with multiscale problems in electromagnetic fields. When used in Maxwell equation, symmetric elements of the matrix are required; otherwise, the algorithm will be unstable. Usually, the electro-thermal problem also contains multiscale structures. However, the coefficient matrix of the heat transfer equation is asymmetric because the parameters of the equation vary with temperature and the Robbin boundary condition is used as well. In this paper, a three-dimensional (3D) finite difference subgridding method is proposed to simulate the electro-thermal coupling process of the multiscale circuits. The stability condition of the algorithm is deduced with a matrix method. And the efficiency and the effectiveness of the proposed subgridding approach are verified through square- and n-shaped resistances. Compared with the results of the COMSOL software and the traditional finite difference method (FDM), the proposed subgridding method has less unknowns and faster speed.
Test des modèles d'Energie Noire et propriétés physiques des amas de galaxies

Les amas de galaxies sont les objets les plus massifs de l'Univers. Leur population etant directement liee au taux de croissance des perturbations de matiere, l'evolution de leur abondance dans le temps permet de poser des contraintes sur l'evolution de l'Univers. La decouverte d'un rayonnement X dans ces objets a permis de mettre en evidence les proprietes du gaz intra-amas ainsi que les differents processus responsable de l'emission X. Grâce a la capacite de spectro-imagerie haute resolution des instruments de derniere generation comme XMM-Newton ou Chandra, les observations ont permis de mieux comprendre l'evolution des amas de galaxies et d'utiliser leur abondance comme un test cosmologique. L'etude statistique optimale de cette population necessite une bonne determination de la masse des amas. Cette quantite n'etant cependant pas mesurable directement, des methodes indirectes ont ete developpees notamment en utilisant des relations d'echelle ce qui permet de relier la masse aux proprietes du gaz intra-amas. Cependant la physique de ce gaz peut engendrer des biais dans la determination de la masse qui se repercutent sur la determination des parametres cosmologiques. Cette these presente une etude du gaz intra-amas a travers la relation d'echelle masse-temperature a partir des contraintes obtenues grâce a differentes sondes cosmologiques ainsi que la distribution en temperature des amas X. Avec la publication des futurs resultats des experiences Planck, South Pole Telescope ou bien Atacama Cosmology Telescope, une prediction de la population des amas observes par effet Sunyaev-Zel'dovich est detaillee en prenant en compte les proprietes X du gaz intra-amas de facon auto-consistante. Enfin, une etude qualitative du spectre de puissance des anisotropies secondaires du CMB induites par l'effet SZ est proposee afin de montrer les differences observees dans le spectre en prenant en comptes les proprietes du gaz des amas.
brief review on herbal lipsticks using natural colorants over synthetic colorants

Nowadays herbal lipsticks are gaining popularity because natural cosmetics are safe to use. Synthetic coloring agents may cause allergic reactions and are found to be carcinogenic. We will study how the coloring matter from natural sources such as beetroot, grapes, blueberry, papaya, tomato, strawberry, watermelon, pomegranate, etc is beneficial over synthetic colorants in the preparation of lipsticks.Natural ingredients such as beeswax, carnauba wax, white soft paraffin, vanilla essence, castor oil, and vitamin E formulate herbal lipstick. Natural colorants in cosmetics also show different activities such as anti-anti-cancer, anti-oxidant, anti-microbial, anti-inflammatory, rich in vitamins, reducing the appearance of dark spots, fine lines, and wrinkles, and protecting from UV radiation, etc.
Child Behavior Problems as Predictors of Stress in Parents of Children with Developmental and Intellectual Disabilities in Four Emirates of the United Arab Emirates

ABSTRACT Background This study investigates the impact of behavior problems on stress that parents may experience due to raising children with intellectual and developmental disabilities, in relation to various child and parental characteristics. Method 175 parents of children with developmental and/or intellectual disabilities and with behavior problems from four Emirates of the United Arab Emirates (UAE) completed a quantitative questionnaire. Results Parental stress was significantly correlated with children’s behavior problems as indicated by t-test, correlation, and regression analysis. Parents’ stress was also correlated with the type and severity of children’s disability, children’s gender, and children’s age group of 16–20 years. Parents’ stress increased with mothers’ age at 21–30 years and decreased where a housemaid was employed. However, parents’ stress was lowest when the housemaid provided no service to the child. There was no relationship between parents’ stress and their gender, level of education, or marital status. Conclusion The UAE government and non-governmental groups should take steps to improve the psychological well-being of parents of children with developmental and/or intellectual disabilities and behavior problems, a key intervention being the enhancement of behavioral support services to such parents.
Comparative Study of Chemical Composition and Antioxidant Activity of Essential Oil Extracted from Acorus calamus L. Leaves

Acorus calamus L. (Araceae) is perennial, semi aquatic and aromatic medicinal herb exist in both temperate and sub temperate region with sharp pointed, long erect leaves. Acorus calamus is a well known herb with useful bioactive properties in indigenous medicine for centuries in India (Mehrotra et al., 2003). This plant is an evergreen herb up to 6 feet tall and is cosmopolitan in distribution ranging from Europe, East Asia, and North America. It has been reported that in America and Indonesia Acorus calamus is used as herbal medicines to treat gastrointestinal disorders like colic pain, diarrhea and diabetes (Gilani et al., 2006; Si et al., 2006). Its uses for the treatment of fever, cough, bronchitis, inflammation, depression, tumors, hemorrhoids, numbness, skin diseases, general debility and as antidotes for several poisoning have been reported (Vaidyaratnam, 1994). Terpenoids, flavonoid and Journal of Herbal Drug
Decidability of Higher-Order Subtyping via Logical Relations

This paper uses logical relations for the rst time to study the decidability of type-checking and subtyping. The result is proved for F ! , a language with higher-order sub-typing and bounded operator abstraction not previously known to be decidable. The proof is via an intermediate system called a typed operational semantics, leading to a powerful and uniform technique for showing metatheoretic results of type systems with subtyping, such as strong normalization, subject reduction and decidability of subtyping.