Miracle-dz/UniFAR-FTUs huggingface dataset:
AHA-Circ. Research

Caveolae harbor different serpentine receptors, intracellular components of signaling cascades, and certain enzymes, including endothelial nitric oxide synthase (eNOS). The regulation of eNOS activity by Ca /calmodulin and caveolin has been described. We have previously demonstrated that nitric oxide (NO) can modulate signaling initiated via receptors localized to caveolae. In the present study, we show that NO donors induced an increase in the monomeric form of this scaffolding protein in cultured endothelial cells, the effect mimicked by 8-bromo cGMP. Proximity imaging of endothelial cells transfected with the thermotolerant green fluorescent protein–caveolin-1 construct demonstrated that sodium nitroprusside resulted in the increased fluorescence ratio of 410:470 nm, consistent with the distancing of fluorescently tagged caveolin-1. Pulse labeling of endothelial cells with cholera toxin B subunit indicated that sodium nitroprusside reversibly decreased its binding. Signaling via G protein–coupled receptors resident to caveolae was inhibited by pretreatment with NO donor. The data demonstrate that NO modulation of cell signaling is accomplished in part by regulating the state of caveolin-1 oligomerization. NO-induced attenuation of signaling involves reversible dissociation of caveolin scaffold, thus providing both spatial and temporal modulation of signal transduction. (Circ Res. 2001;88:229-236.)
Microsoft Word-Charlotte1.docx

Animal individuality is challenging to explain because individual differences are regulated by multiple selective forces that lead to unique combinations of characteristics. For instance, the study of personality, a core aspect of individuality, may benefit from integrating other factors underlying individual differences, such as lateralised cerebral processing. Indeed, the approach-withdrawal hypothesis (the left hemisphere controls approach behaviour, the right hemisphere controls withdrawal behaviour), may account for differences in boldness or exploration between left and right hemispheric dominant individuals. To analyse the relationships between personality and laterality we tested 80 male piglets with established laterality patterns for two motor functions (tail curling direction and the side of the snout used for manipulation) and a combined classification integrating both motor functions using cluster analysis. We analysed basal salivary testosterone and cortisol along with their behaviour in standardized tests as pre-established indicators of different personality traits (Boldness, Exploration, Activity, Sociability and Coping). We found that the direction of the single motor biases showed significant associations with few personality traits. However, the combined laterality classification showed more, and more robust, significant associations with different personality traits compared to the single motor biases. These results supported the approach-withdrawal hypothesis because right-biased pigs were bolder and more explorative in a context of novelty. Additionally, right-biased pigs were more sociable than left-biased pigs. Therefore, the present study indicates that personality is indeed related to lateralised cerebral processing and provides insight into the multifactorial nature of individuality.
FORMULATION AND EVALUATION OF VALSARTAN MICROSPHERES BY IONOTROPIC GELATION TECHNIQUE

In this present research study, an attempt was made to develop valsartan microspheres and consider the influence of various concentrations of sodium alginate and calcium chloride on particle size, entrapment efficiency, and drug release of the same. These microspheres were prepared by ionotropic gelation technique for oral delivery in the treatment of Hypertension. The formulated microspheres were evaluated regarding entrapment efficiency, percentage yield, drug release and characterization was studied using FTIR and SEM analysis. Among the total 14 formulations, S12 formulation was optimized at 2% of sodium alginate, 10% of calcium chloride with pectin. The in vitro dissolution showed sustained release of Valsartan up to 97.89±5.25 by diffusion mechanism over 12h, which followed the zero order and Higuchi model (R 2 = 0.990, 0.979) respectively, the drug release from microspheres was anomalous Non fickian diffusion. From these results it was concluded that, optimized formulation is stable and retained their original properties with minor differences. Valsartan alginate microspheres is an effective drug delivery system that offers more predictable and extensive drug release and helps in the treatment of Hypertension.
Calcium Channel Antagonists

The w-conotoxins, a class of Ca2+ channel antagonists from fish-hunting marine snails, have recently been described (Olivera, B. M., McIntosh, J. M., Zeikus, R., Gray, W. R., Varga, J., Rivier, J., de Santos, V., and Cruz, L. J. (1985) Science, 230, 1338-1343). One of these peptide neurotoxins, w-conotoxin GVIA, was radiolabeled with iodine, and the lZ5I-labeled toxin was shown to bind specifically to high affinity sites on chick brain synaptosomes. The toxin-receptor complex was extremely stable; addition of an excess of unlabeled toxin did not cause significant displacement of the labeled toxin after 2 h. Binding competition data suggest that w-conotoxin defines a new high affinity receptor site affecting voltage-activated Ca2+ channels, distinct from both the verapamil and dihydropyridine target sites.
Root Nodulation of Sesbania rostrata IBRAHIMA

The tropical legume Sesbania rostrata can be nodulated by Azorhizobium caulinodans on both its stem and its root system. Here we investigate in detail the process of root nodulation and show that nodules develop exclusively at the base of secondary roots. Intercellular infection leads to the formation of infection pockets, which then give rise to infection threads. Concomitantly with infection, cortical cells of the secondary roots dedifferentiate, forming a meristem which has an "open-basket" configuration and which surrounds the initial infection site. Bacteria are released from the tips of infection threads into plant cells via "infection droplets," each containing several bacteria. Initially, nodule differentiation is comparable to that of indeterminate nodules, with the youngest meristematic cells being located at the periphery and the nitrogen-fixing cells being located at the nodule center. Because of the peculiar form of the meristem, Sesbania root nodules develop uniformly around a central axis. Nitrogen fixation is detected as early as 3 days following inoculation, while the nodule meristem is still active. Two weeks after inoculation, meristematic activity ceases, and nodules then show the typical histology of determinate nodules. Thus, root nodule organogenesis in S. rostrata appears to be intermediate between indeterminate and determinate types.
The Impact of Subsidies on Czech Firms

1 University of Economics, W. Churchill Sq. 4, 130 67 Prague 3, Czech Republic. Corresponding author: e-mail: potluka@vse.cz. 2 University of Economics, W. Churchill Sq. 4, 130 67 Prague 3, Czech Republic. 3 Czech Statistical Office, Na Padesatém 81, 100 82 Prague 10, Czech Republic. 4 University of Economics, W. Churchill Sq. 4, 130 67 Prague 3, Czech Republic. 5 University of Economics, W. Churchill Sq. 4, 130 67 Prague 3, Czech Republic. Abstract
Stochastic Models of CP Flows over 802.11 WLANs

This technical report develops an analytical framework to model the interaction between TCP and 802.11 MAC protocol over a WLAN, when concurrent TCP downlink and uplink connections are active. Assuming a TCP advertised window equal to one, we formulate a Markov model to characterize the dynamic network contention level, defined as the expected number of wireless stations having at least a frame to transmit. Exploiting the stochastic characterization of the dynamic contention level induced by the TCP flow control, we develop an accurate model of the MAC protocol behavior to evaluate the TCP throughput performance. Comparison with simulation results validates the model, which provides the analytical basis for the optimization of the system performance. In particular, we prove that using a TCP advertised window equal to one ensures a fair access to the TCP flows of the channel bandwidth, irrespective of the number of TCP downlink or uplink connections. Moreover, we show that the aggregate TCP throughput is almost independent of the number of wireless stations in the network. Index Terms WLAN, 802.11 MAC Protocol, TCP, Throughout Analysis, Markov Model, Performance Evaluation.
Inverse modeling for fast design optimization of small‐size rat‐race couplers incorporating compact cells

In the paper, a framework for computationally‐efficient design optimization of compact rat‐race couplers (RRCs) is discussed. A class of hybrid RRCs with variable operating conditions is investigated, whose size reduction is obtained by replacing ordinary transmission lines with compact microstrip resonant cells (CMRCs). Our approach employs a bottom‐up design strategy leading to the development of compact RRCs through rapid design optimization of its building blocks and a subsequent fine tuning to account for parasitic cross‐coupling effects. The fundamental component of the proposed method is an inverse CMRC surrogate model, covering a wide range of cell electrical parameters, and enabling a convenient adjustment of coupler bandwidth. Having the surrogate model established, it is possible to produce close‐to‐optimum CMRC dimensions at a negligible computational cost. The subsequent correction step requires only up to two electromagnetic simulations of the CMRC. The proposed method is demonstrated by designing an RRC for several operational bandwidths. Experimental results are also provided.
Intra- and inter-regional diversification, subsidiary value chain activities and expatriate utilization

Although it is well established in the current staffing literature that why and how multinational enterprises (MNEs) allocate more or fewer expatriates in some subsidiaries than others, little is known about why and how some MNEs utilize more or fewer expatriates than other MNEs. This paper builds on regionalization theory to argue that intraand inter-regional diversification has to do with the overall use of expatriates in MNEs. An empirical investigation of Korean MNEs demonstrates that the degree of intraand inter-regional diversification has significant impacts on the level of expatriate utilization by MNEs. The results also reveal an interesting moderating influence of subsidiary value chain activities. MNEs tend to vigorously adjust their use of expatriates in downstream subsidiaries depending on the degree of intraand interregional diversification. However, they do not adjust their use of expatriates in manufacturing subsidiaries upon the degree of international diversification. Overall, this study extends our understanding of how MNEs manage a geographically dispersed organization in a semiglobalized world.
ATOMISTIC SIMULATIONS OF Ti ADDITIONS TO NIAI GUILLERMO BOZZOLO', RONALD D. NOEBE", ANITA GARG'"

The development of more efficient engines and power plants for future supersonic transports depend on the advancement of new high-temperature materials with temperature capabilities exceeding those of Ni-based superalloys. Having theoretical modelling techniques to aid in the design of these alloys would greatly facilitate this development. The present paper discusses a successful attempt to correlate theoretical predictions of alloy properties with experimental confirmation for ternary NiAI-Ti alloys. The B.F. S. (Bozzolo-Ferrante-Smith) method for alloys is used to predict the solubility limit and site preference energies for Ti additions of I to 25 at. % to NiAI. The results show the solubility limit to be around 5 % Ti, above which the formation of Heusler precipitates is favored. These results were confirmed by transmission electron microscopy performed on a series of NiAI-Ti alloys.
GESTÃO DE RECURSOS HÍDRICOS NA AMAZÔNIA: UM PANORAMA DA PARTICIPAÇÃO DA SOCIEDADE CIVIL NOS ESPAÇOS DELIBERATIVOS

O atual modelo de gestao hidrica no Brasil, inserido pela Lei no. 9.433/1997, foi um marco da governanca hidrica no pais ao prever a descentralizacao nas tomadas de decisao e proporcionar a participacao dos diversos “stakeholders”. Nesse sentido, a pesquisa objetivou investigar a efetividade da Politica Nacional de Recursos Hidricos nos estados da Amazonia Legal sob o vies da participacao da sociedade civil e do acesso a informacao nos Conselhos Estaduais de Recursos Hidricos. Para tanto, realizou-se uma pesquisa descritiva e exploratoria, mediante levantamento bibliografico e documental, com analise de decretos de nomeacao e atas de reuniao para identificar o quantitativo de representantes dos diversos atores, bem como aplicou-se uma estatistica multivariada por meio do software Minitab 17 no tratamento de dados a fim de investigar as similaridades entre os estados. A pesquisa constatou que a efetivacao da referida politica publica de forma descentralizada nos estados brasileiros da Amazonia Legal ainda nao ocorreu satisfatoriamente no que refere a promocao da participacao da sociedade civil e ao acesso a informacao, havendo a necessidade do investimento em educacao ambiental e maior disponibilidade de informacao e facilitacao do seu acesso.
Characterization and batch testing of a secondary lead slag

The emphasis of this paper is on the characterization and testing of the slag produced by a secondary lead refinery. This work forms part of a broader investigation aimed at reducing loss of valuable product from the process as well as minimizing the environmental impact of the process wastes. It was this work that led to a critical examination of the standard waste classification tests. Characterization of the slag was carried out using a number of complementary techniques. In the broader context, the slag characterization aided in identifying process deficiencies and thus was a critical tool in suggesting potential for process optimization. For this study, the slag characterization provided a relatively comprehensive picture of the composition and properties of the slag, which facilitated understanding the behaviour of the slag under batch test conditions. On the basis of quantity of hazardous components alone, the slag is hazardous according to South African Acceptable Risk Limits (ARL). However, when both the quantity and the leach potential of the hazardous components is taken into account, standard waste tests carried out by three independent agencies indicate that the slag should not be classified as hazardous according to local regulations. Also, according to United States Environmental Protection Agency (US EPA) limits, which are independent of the quantity of the waste, the slag would not be classified as hazardous. The standard waste tests used by the independent agencies was the Toxicity Characteristic Leach Procedure (TCLP), a test which was developed by the US EPA to classify hazardous wastes. One of the requirements of this batch test is that it should be quick, simple to carry out and that the results should be reproducible. Previously, the applicability of the TCLP test to mineral processing and metallurgical wastes has been challenged on a number of points. Additional testing of the slag was carried out using both the TCLP and the Synthetic Precipitation Leach Procedure (SPLP) recommended by the American National Mining Association as being more appropriate for mineral processing wastes. The particular physical and chemical characteristics of the secondary lead slag highlighted additional limitations of both the TCLP and SPLP tests as standard laboratory batch procedures. Keywords: environmental protection, secondary lead processing, slag, leach testing, TCLP, SPLP, ARL, hazardous waste, batch tests
Aalborg Universitet Innovations and Experience Economy a tool for rural food sector competitiveness and rural development

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A MACHINE LEARNING METHOD TO IDENTIFY HATE SPEECH USING TRIMODEL APPROACH

Classification options were derived from the content of every tweet, as well as grammatical dependencies between words to acknowledge “othering” phrases, incitement to reply with antagonistic action, and claims of sensible or even discrimination against social teams. The results of the classifier were best employing a combination of probabilistic, rule-based, and spatial-based classifiers with a voted ensemble meta-classifier. I incontestible however the results of the classifier will be robustly utilised during a applied math model wont to forecast the seemingly unfold of cyber hate during a sample of Twitter information. The applications to policy and deciding ar mentioned. I planned a cooperative multi-domain sentiment classification approach to coach sentiment classifiers for multiple domains at the same time. In our approach, the sentiment info in numerous domains is shared to coach a lot of correct and strong sentiment classifiers for every domain once labelled information is scarce. Specifically, I decompose the sentiment classifier of every domain into 2 parts, a world one and a domain-specific one. the worldwide model will capture the overall sentiment information and is shared by varied domains. The domain-specific model will capture the precise sentiment expressions in every domain. additionally, we tend to extract Tri_Model(Naive mathematician IBK,SVM)sentiment information from each labeled and unlabeled samples in every domain and use it to reinforce the educational of Tri_Model ( Naive bayes,IBK,SVM)sentiment classifiers. Besides, we tend to incorporate the similarities between domains into my approach as regularization over the Tri_Model(Naïve bayes mathematician IBK,SVM)sentiment classifiers to encourage the sharing of sentiment info between similar domains. 2 styles of domain similarity measures ar explored, one supported matter content and therefore the different one supported sentiment expressions. Moreover, I introduce 2 economical algorithms to resolve the model of our approach. Experimental results on benchmark datasets show that our approach will effectively improve the performance of multi-domain sentiment classification and considerably vanquish baseline ways.
Future Irregular Computing with Memory Accelerators

—Effective memory bandwidth for irregular applications such as a CG (Conjugate Gradient) solver and graph processing for larger sparse matrices must be accelerated with lower power in the future. Since the total performance of such HPC (High Performance Computing) applications is limited by memory bandwidth, smart memory is a possible lower power accelerator than GPUs (Graphics Processing Units). In this paper, we propose a GPU based HPC system using memory accelerators with gather functions and a HMC (Hybrid Memory Cube) interface. We implemented CG solver for it. The memory accelerator converts indirect accesses, which are unsuitable for cache and device memory, into direct accesses using gather functions. This paper presents the performance of the proposed memory architecture with University of Florida Sparse Matrix Collection. The result shows 1.01 to 1.20 times acceleration by the memory accelerator against the texture cache, even in the case of small matrices that take advantage of texture cache effects. The ratio will dramatically increase when the gap of the cache capacity and the matrices size increases. The scalability of the proposed method is guaranteed by the scalable broadcast thorough interconnection network.
E cacy of integrating vestibular rehabilitation and cognitive behaviour therapy in persons with long- term dizziness in primary care– a study protocol for a randomised controlled trial

Lene Kristiansen (  lene.kristiansen@hvl.no ) Hogskulen pa Vestlandet Avdeling for helseog sosialfag https://orcid.org/0000-0001-6662-9117 Liv Heide Magnussen Western Norway University of Applied Sciences Kjersti Thulin Wilhelmsen Western Norway University of Applied Sciences Silje Mæland Western Norway University of Applied Sciences Stein-Helge Glad Nordahl University of Bergen Richard Clendaniel Duke University School of Medicince Anders Hovland University of Bergen Birgit Juul-Kristensen University of Southern Denmark
Ethylene contributes to mir 1-mediated maize defense against the phloem-sap sucking insect 31 Rhopalosiphum maidis

1 Running Title: Ethylene dependent mir1 resistance to aphids 1 2 3 Author for Correspondence: Joe Louis 4 Department of Entomology and Department of Biochemistry 5 University of Nebraska-Lincoln 6 Lincoln, NE 68583, USA 7 8 Phone: (402) 472-8098 9 Fax: (402) 472-4687 10 E-mail: joelouis@unl.edu 11 12 13 14 Research Area: Signaling and Response 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 Plant Physiology Preview. Published on August 7, 2015, as DOI:10.1104/pp.15. 00958
Myosin VI: Roles for a Minus End-directed Actin Motor in Cells

The recent discovery that the class VI myosin is minus end-directed (Schliwa, 1999; Wells et al., 1999) allows new mechanisms of actin-based motility to exist in cells. This will prompt reexamination of a broad range of cell movements previously difficult to explain by conventional force generating mechanisms. Myosins are a large family of molecular motor proteins divided into 15 or more classes, and are the only known type of actin-based motor. Intrinsically, an individual myosin converts energy derived from ATP hydrolysis into unidirectional movement towards only one specified end of an actin filament: either the plus (barbed-) or minus (pointed-) end. Minus end directionality in myosin VI is unique: all other myosins tested are plus end-directed actin motors. Myosin VI plays a key role in cell motility and shape change events in many animal species (Table I), and is essential for hearing in mice (Avraham et al., 1995) and fertility in flies (Hicks et al., 1999). This review discusses two plausible basic molecular functions for a minus end-directed actin motor in a cell: transportation of cargo, an expected role for an actin motor; and generation of cell expansion force, a new theory. I then speculate how cargo transport and cell expansion force participate in three distinct shape change events in which myosin VI activity is important.
МЕДИЦИНА И ФАРМАЦИЯ MEDICINE AND PHARMACY

Early recognition of fertility after hernia repair surgery performed according to different methods is still a challenging task. The paper discusses the study of matrix metalloproteinase-9 (ММР-9) content in ejaculate after the hernia repair surgery. The clinical research study is based upon the results of inguinal hernia repair in 68 male patients at the age from 18 to 40. The elevated concentration of ММР-9 content in ejaculate is conclusively ascertained even at early cases of disease processes after the hernia repair surgery. High content of ММР-9 in the ejaculate of patients operated for the hernia repair shows that this enzyme takes part in the after surgery disease process. Along with that it is possible to say that not only the chemical composition but the implant surface morphology as well is an important characteristic that influences the body response to the synthetic material. The results of the study give reasons to consider the elevated content of ММР-9 in ejaculate the evidence of a long-continued inflammatory process. In the surgery performed with Desarda techniques with no synthetic implants introduced, the above said value is reduced many times. The detection of metalloproteinase (ММР-9) in ejaculate can be considered as a criterion for choice of hernia repair surgery for fertile men.