Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of Gleason score of Prostate Cancer at Ultrasound/MRI Fusion Target Biopsy vs. Systematic Transrectal Ultrasound Guided Biopsy with Final Gleason score at Radical Prostatectomy

Purpose: To compare accuracy in predicting final Gleason Grade Group (GGG) of Prostate Cancer (PCa) of US/MRI fusion guided target (fBx) vs. systematic Transrectal Ultrasound-Guided (TRUS) biopsy, using histopathologic analysis at prostatectomy as the gold standard. Materials and methods: After obtaining IRB approval, we retrospectively reviewed records of patients who underwent Radical Prostatectomy (RP) from January 2014 through May 2019 with prior US/MRI fusion guided target or TRUS biopsy. The rates of upgrading (RP GGG > BX GGG), downgrading (RP GGG < BX GGG), and concordance (RP GGG = BX GGG) were compared between the fBx and TRUS groups. Age, PSA, PSA density, and prostate volume were also noted for all patients. Statistical analysis was utilized to assess the data. Results: A total of 348 men with complete clinical data were included in this study. The rate of downgrading and upgrading in the fBx group was less than in the TRUS biopsy group (14% vs. 19.6%, and 13.2% vs. 19.6%, respectively). The concordance rate was higher in the US-MR fBx group (72.9% vs. 60.7%, p < 0.05)) across all GGG. Notably, lower rates of concordance were found for GGG 1 (24.1%) and GGG 4 (3.6%) in the TRUS Bx group. Patients who underwent US-MR fBx had higher average PSA (9.4 vs. 6.5 ng/ml), higher PSA density (0.3 vs. 0.2 ng/ml2), and lower prostate volume (31 vs. 42 cc). Additionally, biopsy results showed a lower rate of GGG 1 (3.1% vs. 13.2%) and a higher rate of GGG 5 (14.7% vs. 5.5%) in the US-MR fBx group. Conclusions: Target biopsy has a higher GGG concordance compared to TRUS biopsy (72.9% vs. 60.7%, p < 0.05). In addition, there was less downgrading or upgrading of final PCa GGG in the fBx groups compared to TRUS Bx (14% vs. 19.6%, 13.2% vs. 19.6%, respectively). This finding may have important implications for treatment decisions.
Massless scalar fields and infrared divergences in the inflationary brane world

We study the quantum effects induced by bulk scalar fields in a model with a de Sitter (dS) brane in a flat bulk (the Vilenkin–Ipser–Sikivie model) in more than four dimensions. In ordinary dS space, it is well known that the stress tensor in the dS invariant vacuum for an effectively massless scalar ( with the Ricci scalar) is infrared divergent except for the minimally coupled case. The usual procedure for taming this divergence is replacing the dS invariant vacuum by the Allen–Follaci (AF) vacuum. The resulting stress tensor breaks dS symmetry but is regular. Similarly, in the brane world context, we find that the dS invariant vacuum generates divergent everywhere when the lowest lying mode becomes massless except for the massless minimal coupling case. A simple extension of the AF vacuum to the present case avoids this global divergence, but remains divergent along a timelike axis in the bulk. In this case, singularities also appear along the light cone emanating from the origin in the bulk, although they are so mild that stays finite except for non-minimal coupling cases in four or six dimensions. We discuss implications of these results for bulk inflaton models. We also study the evolution of the field perturbations in dS brane world. We find that perturbations grow linearly with time on the brane, as in the case of ordinary dS space. In the bulk, they are asymptotically bounded.
Cardiac Magnetic Resonance in Fabry Disease: Morphological, Functional, and Tissue Features

Fabry disease (FD) is an X-linked inheritable storage disease caused by a deficiency of alpha-galactosidase causing lysosomal overload of sphingolipids. FD cardiomyopathy is characterized by left ventricular (LV) hypertrophy and should be considered in differential diagnosis with all the other causes of LV hypertrophy. An early diagnosis of FD is very important because the enzyme replacement therapy (ERT) may change the fate of patients by blocking both cardiac and systemic involvement and improving prognosis. Diagnosis may be relatively easy in young patients with the typical signs and symptoms of FD, but in male patients with late onset of disease and in females, diagnosis may be very challenging. Morphological and functional aspects are not specific to FD, which cannot be diagnosed or excluded by echocardiography. Cardiac magnetic resonance (CMR) with tissue characterization capability is an accurate technique for the differential diagnosis of LV hypertrophy. The finding of decreased myocardial T1 value in LV hypertrophy is specific to FD. Late gadolinium enhancement (LGE) is found in the late stage of the disease, but it is useful to predict the cardiac response to ERT and to stratify the prognosis.
Detecting malicious domain names from domain generation algorithms using bi-directional LSTM network

DNS (Domain Name System /DNS) is one of the most important infrastructures of Internet. People can easily access the rich network resources worldwide using the DNS technology. However, the Domain Generation Algorithm (DGA) is also accompanied by the DNS technology, which is used to generate malicious domain names. To detect DGA malicious domains, the previous studies often used unreal small DNS domain name datasets to train the detection models that always overlooked real user data traffic. These models generally did not have good generalization performance. In this paper, we propose a new DGA malicious domain name detection model based on Bi-directional LSTM network. We also propose a new evaluation metric to evaluate the real unlabeled DNS traffic data. Compared with LSTM model, the detection effect of our proposed model is improved effectively. The experimental results show that the precision of the model and the value of AUC reach 98.4% and 0.9079, respectively.
TAXA DE INCIDÊNCIA E PERCAS ECONÔMICAS POR HEMATOMAS EM BOVINOS DE CORTE EM DIFERENTES DISTÂNCIAS DE TRANSPORTE ATÉ O FRIGORÍFICO DO MUNICÍPIO DE CACOAL – RO

Os hematomas são umas das principais causas de perca de rendimento de carcaça, além dos grandes defeitos na qualidade é o que causa perca monetária tanto para os produtores quanto para as indústrias, essas lesões se dão por conta do manejo indevido para com os animais, como a forma de contenção ou o transporte e as condições das estradas, o que infelizmente ocasiona a cerca de 1% a 2% de perca de peso por carcaça quente. Os Serviços de Inspeção exigem que essas lesões sejam retiradas ainda no processo de abate. As contusões são medidas referentes a tamanhos e profundidades, elas são classificadas em Grau I, atingindo apenas o subcutâneo (gordura), Grau II (atinge o subcutâneo e uma certa camada do músculo) e Grau III (alcançando boa parte do músculo podendo condenar boa parte da carcaça). Contudo foi abatido bovinos provenientes de 21 municípios do Estado de Rondônia, localizado na Região Norte do País. 1996 animais apresentaram algum tipo de hematoma, em meio as carcaças estudadas o traseiro foi umas das regiões mais afetadas. Como conclusão a distância entre as propriedades e a indústria teve um efeito significativa nos resultados adquiridos, junto ao sexo e a idade dos animais.
A Multi-Gateway Behaviour Study for Traffic-Oriented LoRaWAN Deployment

The advantages of LoRaWAN over conventional networks (GSM, 4G, 5G) in terms of investment and operating costs have been proven for network coverage in urban and rural areas. However, the theoretical coverage compared to the reality on the ground and the quality of service (QoS) provided remain very relative and depend on several technical factors, subject to increased research. Several recent approaches and hardware specifications recommended adding gateways as a solution to improve the LoRaWAN QoS indicators, mainly for high-traffic situations. However, such a solution will not work in all real-life scenarios since many factors must be considered. This article presents a study of the factors impacting the LoRaWAN QoS in the case of the usage of multiple gateways by exploring different scenarios to show how the payload length impacts the whole network’s packet delivery ratio (PDR) and how it interacts when enhancing the GW number with and without confirmed traffic. Based on the simulation results, increasing the number of gateways can negatively impact the network’s ability to support higher payload packets, especially in a high-traffic scenario. More precisely, we can say that for a low number of GWs, it is more appropriate to use a high payload length since we can achieve a high PDR. Nevertheless, with a high number of GWs, it would be more appropriate to use a low payload length to achieve a good PDR. Similarly, our analyses show that increasing the number of gateways ensures a better PDR but with a significant packet loss at the gateways, which is synonymous with higher energy consumption.
XRB continuum fitting with sensitive high-energy X-ray detectors

The launch of the Nuclear Spectroscopic Telescope Array (NuSTAR) heralded a new era of sensitive high-energy X-ray spectroscopy for X-ray binaries (XRBs). In this paper we show how multiple physical parameters can be measured from the accretion disc spectrum when the high-energy side of the disc spectrum can be measured precisely using NuSTAR. This immediately makes two exciting developments possible. If the mass and distance of the source are known, the continuum fitting method can be used to calculate the spin and inner disc inclination independently of the iron line fitting method. If the mass and distance are unknown, the two methods can be combined to constrain these values to a narrow region of parameter space. In this paper we perform extensive simulations to establish the reliability of these techniques. We find that with high-quality spectra, spin and inclination can indeed be simultaneously measured using the disc spectrum. These measurements are much more precise at higher spin values, where the relativistic effects are stronger. The inclusion of a soft X-ray snapshot observation alongside the NuSTAR data significantly improves the reliability, particularly for lower temperature discs, as it gives a greatly improved measurement of the disc peak. High signal-to-noise data are not necessary for this, as measuring the peak temperature is relatively easy. We discuss the impact of systematic effects on this technique, and the implications of our results such as robust measurements of accretion disc warps and XRB mass surveys.
Long-term evolutions of the cyclotron line energies in Her X-1, Vela X-1, and Cen X-3 as observed with Swift/BAT

We study the long-term evolution of the centroid energy of cyclotron lines - often referered to as Cyclotron Resonance Scattering Features (CRSF) - in Her X-1, Vela X-1 and Cen X-3, using survey observations of the Burst Alert Telescope (BAT) onboard Swift. We find a significant decrease of the fundamental CRSF energy in Her X-1 and the first harmonic line energy in Vela X-1, since the launch of Swift in 2004 and until 2010 and 2012, respectively.In both sources the decreases stopped at some time, with a quite stable centroid energy thereafter. Unlike in Her X-1 and Vela X-1, the CRSF energy in Cen X-3 does not show a long-term decrease. It is observed not to change for at least the past 14 years. The long-term variation of the line energy is a direct way to investigate the magnetic field structure in the polar regions of pulsars. Our results may stimulate the development of theoretical models, especially regarding to how the accreted mass accumulates in the accretion mound or how the magnetic field distorts around the polar cap.
Perspectives on challenges and opportunities at the restoration‐policy interface in the U.S.A.

As we advance into the United Nations Decade on Ecosystem Restoration, understanding the relationship between science, management, and policy is increasingly important given the paucity of research evaluating the ability of existing policy to address contemporary environmental challenges. Despite their inherent interdependence, restoration ecology as a scientific discipline, ecological restoration as a practice, and the policies driving restoration efforts do not always represent a unified force. Accenting the policies and practices within the United States, we present our perspective on challenges associated with this disunion, including those linked to social dimensions of restoration and limitations associated with existing policy. We provide a review of existing federal policy in the United States and synthesize suggestions that have emerged in the literature to fortify connections between restoration science and policy. We also describe social challenges to meeting restoration goals, including barriers surrounding power dynamics, trust, and communication, as well as divergent incentives, perspectives, and values. We propose potential solutions that exist in transdisciplinary collaboration and knowledge sharing, and evidence‐based, balanced decision‐making that equally considers varying perspectives. With the understanding that current conservation practices are not enough to mitigate environmental degradation, we focus on streamlining problem‐solving strategies to support restoration and face the widespread ecological issues of today.
Shear-imposed falling thin Newtonian film over a porous slippery surface

The stability of a Newtonian thin film flow over a porous slippery wall approximated by Darcy's law is investigated. The modified Orr-Sommerfeld system is derived for the frequency-dependent linear stability analysis and energy-budget analysis. Moreover, in the longwave regime, both linear and weakly nonlinear stability analysis are conducted for small aspect ratios. In addition, the multiple scale approach is performed directly in the nonlinear deformation equation of the free surface to predict the extraordinary behaviour of the amplitude and speed of the nonlinear disturbance in the subcritical and supercritical regimes. The study finds that the larger slip-velocity and externally imposed shear on the thin film increase the total kinetic energy of the infinitesimal perturbations. In a longwaveregime, the critical conditions of the primary instability are described as a function of imposed shear stress that destabilizes the film flow for low critical Reynolds number. Further, in the supercritical stable zone, both the nonlinear wave amplitude and phase speed increase with an increase of induced shear in the flow direction and velocity slip, and a reverse trend is observed in applying the imposed shear in the opposite flow direction. On the other hand, the nonlinear wave amplitude in the subcritical unstable zone increases and decreases, corresponding to the larger values of imposed shear and slip parameters, respectively.
Degree of regularity for HFE Minus (HFE

In this paper, we prove a closed formula for the degree of regularity of the family of HFE- (HFE Minus) multivariate public key cryptosystems over a nite eld of size q. The degree of regularity of the polynomial system derived from an HFE- system is less than or equal to (q − 1)(⌊log q (D − 1)⌋ + a)
STUDY ON THE EFFECT OF BRAND EQUITY ON IPHONE PRODUCT CUSTOMERS IN SEMARANG CITY

In the growth of the world economy, business competition between companies is tight and increasing, especially in business competition in Indonesia. Many companies are competing to keep their customers in order to keep using the products offered. Every company tries to fulfill the wishes of consumers by delivering the desired goods or services (Halim & Iskandar, 2019). Technology companies are one of the companies that compete in developing their products. This study describes the influence of Perceived Quality, Brand Image, and Brand Experience on Customer Loyalty with Brand Equity as an intermediate variable to iPhone smartphone users in Semarang. The sample needed in this study is iPhone product users who have made purchases and used iPhone products at least 2 times from the type of iPhone product line. Keyword: Perceived Quality, Brand Image, Brand Experience, Brand Equity, Customer Loyalty
Manual Therapy Effect in Placebo-Controlled Trials: A Systematic Review and Meta-Analysis

Purpose: Background: Evaluate whether the design of placebo control groups could produce different interpretations of the efficacy of manual therapy techniques. Methods: Nine databases were searched (EMBASE, CINAHL, PsycINFO, MEDLINE, PubMed, SCOPUS, WEB of SCIENCE, COCHRANE, and PEDro). Randomized placebo-controlled clinical trials that used manual therapy as a sham treatment on subjects suffering from pain were included. Data were summarized qualitatively, and meta-analyses were conducted with R. Results: 53 articles were included in the qualitative analysis and 48 were included in the quantitative analyses. Manipulation techniques did not show higher effectiveness when compared with all types of sham groups that were analyzed (SMD 0.28; 95%CI [−0.24; 0.80]) (SMD 0.28; 95%CI [−0.08; 0.64]) (SMD 0.42; 95%CI [0.16; 0.67]) (SMD 0.82; 95%CI [−0.57; 2.21]), raising doubts on their therapeutic effect. Factors such as expectations of treatment were not consistently evaluated, and analysis could help clarify the effect of different sham groups. As for soft tissue techniques, the results are stronger in favor of these techniques when compared to sham control groups (SMD 0.40; 95%CI [0.19, 0.61]). Regarding mobilization techniques and neural gliding techniques, not enough studies were found for conclusions to be made. Conclusions: The literature presents a lack of a unified placebo control group design for each technique and an absence of assessment of expectations. These two issues might account for the unclear results obtained in the analysis.
Spatio-temporal proper orthogonal decomposition of turbulent channel flow

An extension of proper orthogonal decomposition is applied to the wall layer of a turbulent channel flow ( $Re_{\unicode[STIX]{x1D70F}}=590$ ), so that empirical eigenfunctions are defined in both space and time. Due to the statistical symmetries of the flow, the eigenfunctions are associated with individual wavenumbers and frequencies. Self-similarity of the dominant eigenfunctions, consistent with wall-attached structures transferring energy into the core region, is established. The most energetic modes are characterized by a fundamental time scale in the range 200–300 viscous wall units. The full spatio-temporal decomposition provides a natural measure of the convection velocity of structures, with a characteristic value of 12 $u_{\unicode[STIX]{x1D70F}}$ in the wall layer. Finally, we show that the energy budget can be split into specific contributions for each mode, which provides a closed-form expression for nonlinear effects.
Cosmological landscape and Euclidean quantum gravity

Quantum creation of the universe is described by the density matrix defined by the Euclidean path integral. This yields an ensemble of universes—a cosmological landscape—in a mixed quasi-thermal state which is shown to be dynamically more preferable than the pure quantum state of the Hartle–Hawking type. The latter is suppressed by the infinitely large positive action of its instanton, generated by the conformal anomaly of quantum matter. The Hartle–Hawking instantons can be regarded as posing initial conditions for Starobinsky solutions of the anomaly driven de Sitter expansion, which are thus dynamically eliminated by infrared effects of quantum gravity. The resulting landscape of hot universes treated within the cosmological bootstrap (the self-consistent back reaction of quantum matter) turns out to be limited to a bounded range of the cosmological constant, which rules out a well-known infrared catastrophe of the vanishing cosmological constant and suggests an ultimate solution to the problem of unboundedness of the cosmological action in Euclidean quantum gravity.
Hybrid Gold Nanorod-Based Nanoplatform with Chemo and Photothermal Activities for Bimodal Cancer Therapy

Metal nanoparticles (NPs), particularly gold nanorods (AuNRs), appear as excellent platforms not only to transport and deliver bioactive cargoes but also to provide additional therapeutic responses for diseased cells and tissues and/or to complement the action of the carried molecules. In this manner, here, we optimized a previous developed metal-based nanoplatform composed of an AuNR core surrounded by a polymeric shell constructed by means of the layer-by-layer approach, and in which very large amounts of the antineoplasic drug doxorubicin (DOXO) in a single loading step and targeting capability thanks to an outer hyaluronic acid layer were incorporated by means of an optimized fabrication process (PSS/DOXO/PLL/HA-coated AuNRs). The platform retained its nanometer size with a negative surface charge and was colloidally stable in a range of physiological conditions, in which only in some of them some particle clustering was noted with no precipitation. In addition, the dual stimuli-responsiveness of the designed nanoplatform to both endogenous proteases and external applied light stimuli allows to perfectly manipulate the chemodrug release rates and profiles to achieve suitable pharmacodynamics. It was observed that the inherent active targeting abilities of the nanoplatfom allow the achievement of specific cell toxicity in tumoral cervical HeLa cells, whilst healthy ones such as 3T3-Balb fibroblast remain safe and alive in agreement with the detected levels of internalization in each cell line. In addition, the bimodal action of simultaneous chemo- and photothermal bioactivity provided by the platform largely enhances the therapeutic outcomes. Finally, it was observed that our PSS/DOXO/PLL/HA-coated AuNRs induced cell mortality mainly through apoptosis in HeLa cells even in the presence of NIR light irradiation, which agrees with the idea of the chemo-activity of DOXO predominating over the photothermal effect to induce cell death, favoring an apoptotic pathway over necrosis for cell death.
Bifurcation analysis of a two‐dimensional discrete‐time predator–prey model

The dynamical behavior of a discrete predator–prey system with a nonmonotonic functional response is investigated in this work. We study the local asymptotic stability of the positive equilibrium of the system by examining the characteristic equation of the linearized system corresponding to the model. By choosing the growth rate as a bifurcation parameter, the existence of Neimark–Sacker and period‐doubling bifurcations at the positive equilibrium is established. Furthermore, the effects of perturbations on the system dynamics are investigated. Finally, examples are presented to illustrate our main results.
Crystalline cohomology of algebraic stacks and Hyodo-Kato cohomology

In this text the author uses stack-theoretic techniques to study the crystalline structure on the de Rham cohomology of a proper smooth scheme over a p-adic field and applications to p-adic Hodge theory. He develops a general theory of crystalline cohomology and de Rham-Witt complexes for algebraic stacks and applies it to the construction and study of the ([phi], N, G)-structure on de Rham cohomology. Using the stack-theoretic point of view instead of log geometry, he develops the ingredients needed to prove the Cst-conjecture using the method of Fontaine, Messing, Hyodo, Kato, and Tsuji, except for the key computation of p-adic vanishing cycles. He also generalizes the construction of the monodromy operator to schemes with more general types of reduction than semistable and proves new results about tameness of the action of Galois on cohomology.