Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring the Therapeutic Potential of Royal Jelly in Metabolic Disorders and Gastrointestinal Diseases

Metabolic disorders, encompassing diabetes mellitus, cardiovascular diseases, gastrointestinal disorders, etc., pose a substantial global health threat, with rising morbidity and mortality rates. Addressing these disorders is crucial, as conventional drugs often come with high costs and adverse effects. This review explores the potential of royal jelly (RJ), a natural bee product rich in bioactive components, as an alternative strategy for managing metabolic diseases. RJ exhibits diverse therapeutic properties, including antimicrobial, estrogen-like, anti-inflammatory, hypotensive, anticancer, and antioxidant effects. This review’s focus is on investigating how RJ and its components impact conditions like diabetes mellitus, cardiovascular disease, and gastrointestinal illnesses. Evidence suggests that RJ serves as a complementary treatment for various health issues, notably demonstrating cholesterol- and glucose-lowering effects in diabetic rats. Specific RJ-derived metabolites, such as 10-hydroxy-2-decenoic acid (10-HDA), also known as the “Queen bee acid,” show promise in reducing insulin resistance and hyperglycemia. Recent research highlights RJ’s role in modulating immune responses, enhancing anti-inflammatory cytokines, and suppressing key inflammatory mediators. Despite these promising findings, further research is needed to comprehensively understand the mechanisms underlying RJ’s therapeutic effects.
The Relationship between Body Composition and Jumping Performance of Volleyball Players

Body composition and the skill of jumping are very important for high physical performance in volleyball. The purpose of this study is to analyze the relationship between body composition and jumping performance in female volleyball players aged 14-17. 74 female volleyball players volunteered to participate in the study. The height, body weight, body mass index, body fat percentage, body muscle mass and trunk fat percentage measurements were taken and the vertical jump and standing long jump tests were applied. The data were evaluated with the SPSS 16 statistical software program, the Pearson Correlation test was done for the statistical analysis and the significance level was determined as p< 0.05. The athletes’ vertical jump and standing long jump values were found statistically to have a negative relationship with height, body fat percentage, body muscle mass and body fat percentage, whereas a positive relationship was found between vertical jump and standing long jump values and body weight (p< 0.05). As a result, it was determined that body composition in volleyball players affects jumping performance.
Network analysis of depressive and anxiety symptoms in older Chinese adults with diabetes mellitus

Background The move away from investigating mental disorders as whole using sum scores to the analysis of symptom-level interactions using network analysis has provided new insights into comorbidities. The current study explored the dynamic interactions between depressive and anxiety symptoms in older Chinese adults with diabetes mellitus (DM) and identified central and bridge symptoms in the depression-anxiety network to provide potential targets for prevention and intervention for depression and anxiety. Methods This study used a cross-sectional design with data from the 2017–2018 wave of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). A regularized partial correlation network for depressive and anxiety symptoms was estimated based on self-reported scales completed by 1685 older adults with DM aged 65 years or older. Depressive and anxiety symptoms were assessed using the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10) and the Seven-Item Generalized Anxiety Disorder Scale (GAD-7), respectively. Expected influence (EI) and bridge expected influence (BEI) indices were calculated for each symptom. Results According to cutoff scores indicating the presence of depression and anxiety, the prevalences of depression and anxiety in our sample were 52.9% and 12.8%, respectively. The comorbidity rate of depression and anxiety was 11.5%. The six edges with the strongest regularized partial correlations were between symptoms from the same disorder. “Feeling blue/depressed”, “Nervousness or anxiety”, “Uncontrollable worry”, “Trouble relaxing”, and “Worry too much” had the highest EI values. “Nervousness or anxiety” and “Everything was an effort” exhibited the highest BEI values. Conclusion Central and bridge symptoms were highlighted in this study. Targeting these symptoms may be effective in preventing the comorbidity of depressive and anxiety symptoms and facilitate interventions in older Chinese adults with DM who are at risk for or currently have depressive and anxiety symptoms.
Incidence, Burden, and Trend of Cutaneous Leishmaniasis over Four Decades in Iran

1. Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran 2. Department of Public Health, School of Health, Urmia University of Medical Sciences, Urmia, Iran 3. Department of Nursing and Midwifery, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran 4. Center for Communicable Diseases Control, Ministry of Health and Medical Education, Tehran, Iran 5. Cellular & Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
Importance of Selected Nutrients and Additives in the Feed of Pregnant Sows for the Survival of Newborn Piglets

Simple Summary According to the National Research Council (NRC), during gestation, sows have higher nutritional requirements to meet their needs and those of their fetuses. Therefore, an optimal feeding strategy is essential. Despite the importance of nutrition during gestation, the impact of supplementing the diets of gestating sows with foods rich in fatty acids, protein, amino acids, and dietary fiber on their offspring has not been thoroughly explored, so empirical evidence is scarce. The objective of this review is to evaluate the effect of gestating sows’ nutrition on the survival and postnatal growth of neonate piglets. Sixty percent of the publications reviewed discussed the effect of supplementing diets with one or two of these nutrients, indicating the importance of the topic. Better overall postnatal survival and growth was found to be associated with supplementation with these nutrients during gestation. The studies mainly evaluated the effect of amino acids and fiber, likely because the former are the primary source of protein for the fetus, while the latter exerts an effect on the immune system. Additional research is needed to support these findings. Abstract This systematic review analyzed the effect of selected nutrients and additives in the feed of pregnant sows on the survival of newborn piglets. We analyzed 720 peer-reviewed publications in English in PubMed® and Web of Science®, dated July 2023 to January 2024, related to the effect of dietary supplementation with fatty acids and various percentages of protein, amino acids, and/or sources of dietary fiber on the offspring of gestating sows. While several papers evaluated the effect of nutrition on gestating sows, only a few delved into the distinct feeding strategies required at each stage of gestation to meet the NRC’s nutritional requirements for maternal tissue gain and postnatal neonatal survival and growth. This body of research suggests that as gestation progresses the sow’s nutritional requirements increase, as the NRC established, to satisfy their own metabolic needs and those of their fetuses. Additional research is needed to determine an optimal feeding strategy.
Revitalizing Photoaging Skin through Eugenol in UVB-Exposed Hairless Mice: Mechanistic Insights from Integrated Multi-Omics

Chronic ultraviolet (UV) exposure causes photoaging, which is primarily responsible for skin damage. Nutritional intervention is a viable strategy for preventing and treating skin photoaging. Eugenol (EU) presents anti-inflammatory and antioxidant properties, promotes wound healing, and provides contact dermatitis relief. This study explored the ability of EU to mitigate skin photoaging caused by UVB exposure in vitro and in vivo. EU alleviated UVB-induced skin photodamage in skin cells, including oxidative stress damage and extracellular matrix (ECM) decline. Dietary EU alleviated skin photoaging by promoting skin barrier repair, facilitating skin tissue regeneration, and modulating the skin microenvironment in photoaged mice. The transcriptome sequencing results revealed that EU changed the skin gene expression profiles. Subsequent pathway enrichment analyses indicated that EU might reverse the pivotal ECM–receptor interaction and cytokine–cytokine receptor interaction signaling pathways. Furthermore, EU alleviated the intestinal dysbiosis induced by chronic UVB exposure. Spearman analysis results further revealed the close connection between gut microbiota and skin photoaging. Considering the near-inevitable UVB exposure in modern living, the findings showed that the EU effectively reverted skin photoaging, offering a potential strategy for addressing extrinsic skin aging.
Semiparametric Regression In The Presence Of Measurement Error

The error-in-covariates problem has received great attention among researchers who study semiparametric and nonparametric inference for regression models over the past two decades. Without correcting for the measurement error in covariates, estimators for covariate effect usually contain bias. To account for measurement error, much research have been done in mean regression (Liang et al., 1999; Fuller, 2009; Carroll et al., 2006) and quantile regression (He and Liang, 2000; Hardle et al., 2000; Wei and Carroll, 2009). In contrast, there is little research in mode regression and this motivates us to propose semiparametric methods to address this error-incovariates problem in Chapters 1 and 3. Chapter 1 considers estimating the mode of a response given an error-prone covariate X by assuming that the mode of Y given X is a linear function of X. It is first shown that ignoring measurement error typically leads to inconsistent inference for the mode of the response given the true covariate, as well as misleading inference for regression coefficients in the conditional mode model. To account for measurement error, the Monte Carlo corrected score method (Novick and Stefanski, 2002) is employed to numerically obtain an unbiased score function based on which the regression coefficients is estimated consistently. To relax the normality assumption on measurement error the first method requires, the corrected kernel method is proposed. In this method, an objective function constructed using deconvoluting kernels is maximized to obtain consistent estimators of the regression coefficients. Besides rigorous investigation on large sample properties of the new estimators, we study their finite sample performance via extensive simulation experiments, and find
The effectiveness of micro-needling in the treatment of stretch marks

Introduction: Stretch marks, also known as striae distensae (SD), are a fairly common, asymptomatic skin disorder that affects mostly girls between the ages of 5 and 50. It frequently results in substantial distress and cosmetic anxiety. For the treatment of SD, micro-needling has been suggested as an effective strategy
Cosmic lighthouses at high redshift : intervening material in sight-lines towards GRBs and QSOs

Despite the great progress of our understanding of the Universe in recent decades, largely due to technological advances in instrumentation and astronomical infrastructure, there are still countless observational and theoretical issues that are pending response. In this regard, the recent construction of 8-10 m telescopes, together with the development of CCD devices have allowed us to observe the Universe in a much deeper way, or what is the same, observe it when it was very young. Regarding observational cosmology, in recent decades they have been surveys of the sky where very distant, very young, or even still forming galaxies are detected. As a result, our view of the Universe on a large scale and over long distances has significantly improved, although we have still not done more than scratch the surface. Due to instrumental limitations, surveys that detect the emission of light from distant galaxies are not sufficient to establish the characteristics of the Universe when it was less than 1 Gyr, since the light that reaches us from such remote places in the Cosmos is limited to the brightest sources that existed at the time, which tells us very little about what was “ normal ”in that period. The birth of absorption spectroscopy meant a revolution for observational cosmology. This technique takes advantage of very luminous sources for use as “flashlights” that illuminate the environment between the source and Earth. We infer the properties of this environment not through its light, but through its “shadows”. These flashlights were originally young, massive stars, which allowed us to study our own Galaxy. However, if what we seek is out of our immediate environment, we need in this case not only flashlights, but powerful “beacons” located at great distances. Fortunately, our Universe is far from being a quiet place and we can find phenomena, both permanent and transient, energetic enough to generate the necessary amount of electromagnetic radiation as to act as “cosmic beacons” even on the edge of the observable Universe. The two types of objects that have traditionally been used as illuminating sources are quasars or QSOs, which are permanent sources, and gamma-ray bursts
THE CALCITIC WALL IN THE PALEOZOIC FAMILIES EUOMPHALIDAE AND PLATYCERATIDAE (ARCHEOGASTROPODA)

The euomphalids and the platyceratids are commonly found in faunas which are rich in calcitic shelled organisms such as the brachiopods, crinoids, and bryozoans but poor in molluscs. It is believed that molluscs were probably in the faunas originally but were not preserved because of their unstable aragonite shells, internal molds are commonly encountered. The euomphalids have an outer and inner layer composed of delicate, fibrous calcite; both layers are relatively thin compared to the middle crossed-lamellar layer. The platyceratids have a very thin simple prismatic, calcitic outer layer and a very thick nacreous layer. The upper Cretaceous euomphalid Weeksia, however, lacks a calcitic outer layer and may not be a euomphalid. In addition, it has transitional structure which suggests an origin for crossed-lamellar structure.
The Influence of Motivation and Work Ability on Employee Performance (Study Case at PT. Jasamarga Tollroad Operator)

This research aims to determine the influence of motivation and work ability on employee performance at PT Jasa Marga Toll Road Operator. The population in this research was 150 employees who worked at PT Jasa Marga Toll Road Operator, while the sample in this research used cluster random sampling. So the units selected as samples were not individuals, but organized groups of individuals, where the samples were all 120 operational employees. The results of multiple linear regression analysis show that motivation and work ability have a positive and significant effect on employee performance. For motivation variable, hoped that there will be an opportunity to provide promotions to employees by simplifying the conditions and stages in the consideration and selection process provided. Meanwhile, for the work ability variable, hoped that the Company can become a forum that facilitates employees to improve their abilities. Apart from that, companies also need to provide opportunities for employees to provide input and responses in resolving the problems and challenges.
Air Pollution and Human Health Risk: Evaluation of Carcinogenic Potential of Urban Airborne Particulate Matter

Urban airborne particulate matter (PM) is known to increase morbidity and mortality due to cardiopulmonary diseases related to inflammatory processes and genotoxic effects. The aim of this thesis is to highlight the toxic and carcinogenic potential of airborne particulate matters collected during different seasons at a site that is located in the northern area of the city of Bologna by using alternative in vitro tests, such as the cell transformation assay with BALB/c 3T3 A31-1-1 and Bhas 42 cells. The purpose is also to evaluate the lifetime cancer risks associated with air inhalation in different sites (rural and urban), by using the relative potency of compounds belonging to the same chemical class (PAHs and nitro-PAHs) and the specific unit of carcinogenic risk. None of the organic or inorganic extracts of PM2.5 and PM1 induced a significant increase in the average number of transformed foci/plate or in the transformation frequency of BALB/c 3T3 A311-1 cells, whereas the results obtained by Bhas 42 cell transformation showed a significant increase in the average number of transformed foci/plate. All the analyzed organic extracts showed promoting effects in Bhas 42 cells. The application of the UR cancer risk to the transformed value of B(a)P equivalents in the winter– autumn campaigns leads to estimate an increase in the cancer risk similar to that defined in the literature (1 x 10-4 for exposure to 1 ng/m3). The calculated cancer risk was about one order of magnitude lower in the summer campaigns. In conclusion, the proposed approach, based on the integration of the data derived from in vitro testing and cancer risk assessment, could represent a reliable model for investigating environmental mixtures and predicting their effects on toxicological relevant endpoints.
Continuously Variable-Frequency Energy-Encrypted Wireless Power Transfer

This paper proposes and implements a novel continuously variable-frequency energy-encrypted wireless power transfer (WPT) system for wireless energy security in multi-receiver applications. To prevent wireless energy from being illegally stolen, the proposed chaotic 2-D frequency-and-duration encryption (FDE) technology directly generates well-defended security keys to guarantee energy security. An LCC-compensated transmitter without using a switched-capacitor array is proposed to competently encrypt the wireless energy into burglarproof energy packages, which are decrypted only by authorized receivers. Then, the concept of the static variable capacitor (SVC) is presented to achieve dynamical impedance compensation for wireless energy decryption in authorized receivers with knowledge of security keys. Consequently, the proposed energy-encrypted SVC-based WPT system can flexibly encrypt and decrypt wireless energy packages in a continuous frequency-and-duration adjustment rather than in a discrete way, thus greatly improving energy security performance. Theoretical analysis, computer simulation and experimental results are provided to verify the feasibility of the proposed continuously energy-encrypted SVC-based WPT system.
Mechanistic investigation of the ameliorative effect of liquiritin on hypoxia/reoxygenation‑induced cardiomyocyte injury based on network pharmacology and in vitro validation

Liquiritin (LIQ) is a flavonoid known for its cardioprotective properties, extracted from Glycyrrhiza uralensis Fisch. The purpose of the present study was to investigate the protective mechanism of LIQ against hypoxia/reoxygenation (H/R) injury through in vitro experiments, with the goal of enhancing its pharmacological effects. Initially, network pharmacology was employed to explore the targets and mechanisms of LIQ. Subsequently, an in vitro H/R model was established using H9c2 cells. Potential targets for LIQ and myocardial ischemia-reperfusion injury (MIRI) were identified through online databases. The STRING, Cytoscape and DAVID databases were used to extract intersecting targets and mechanisms. In vitro experiments were conducted to validate these findings, assessing cardiac enzymes, oxidative stress indicators, mitochondrial fluorescence, apoptotic fluorescence, inflammation and related protein expression. The network pharmacological analysis revealed that the protective effects of LIQ on MIRI involve oxidative stress, inflammation and apoptosis. The results of in vitro experimental validation demonstrated that LIQ significantly reduced the activities of lactated dehydrogenase and creatine kinase isoenzyme-MB (P<0.05 or 0.01), as well as the level of malondialdehyde (P<0.01). It also inhibited the production of reactive oxygen species (P<0.01), the release of inflammatory factors (P<0.05 or 0.01) and apoptosis (P<0.01). By contrast, the LIQ pre-treatment group exhibited a significant increase in mitochondrial membrane potential level (P<0.05 or 0.01) and the activities of antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase (P<0.05 or 0.01). Furthermore, LIQ reduced the protein expressions of TNF-α receptor type 1 (TNFR1) and MMP9, along with the level of NF-κB phosphorylation (P<0.05 or 0.01). In conclusion, LIQ mitigated H/R-induced cardiomyocyte injury through mechanisms that may involve antioxidants, anti-apoptotic effects, protection against mitochondrial damage and suppression of inflammatory levels. These effects are achieved via inhibition of the TNFR1/NF-κB/MMP9 pathway.
Proposed Strategy on Diversity Climate, Organization Development, and Organization Effectiveness in Indonesian Transportation Company

This research aims to comprehensively investigate the impact of diversity climate on organizational development and effectiveness within PT Thomas Gesit, a state-owned enterprise in Indonesia. The study is motivated by the need to address the challenges posed by diversity and its influence on organizational practices, particularly in the context of a specific division within the company. The research is guided by the following objectives: to identify and analyse the organizational practices unique to the company that impact diversity climate and employee collaboration, to implement HR strategies based on the existing conditions for the benefit of similar companies in the industry, and to explore the influence of diversity climate on employee collaboration within the state-owned enterprise. All the source persons’ data is anonymous and presented in pseudonyms to maintains confidentiality regarding the company’s identity, the researcher aims to uphold the principles of responsible scholarship and avoid any unintended repercussions.