Miracle-dz/UniFAR-FTUs huggingface dataset:
THE MAXISET POINT OF VIEW FOR ESTIMATING INTEGRATED QUADRATIC FUNCTIONALS

This paper explores the estimation of R f 2 where f is a functional pa- rameter in the white noise model. To compare different estimation procedures, we adopt the maxiset point of view, i.e., we point out the entire set of functions on which a given procedure achieves a given target rate. Quadratic and soft (local and global) thresholding wavelet procedures are considered. We compute the maxisets for these procedures and prove that, most of the time, thresholding procedures out- perform the quadratic one. The comparison of performances in the maxiset setting of local and global thresholding depends on the target rate; none of them is always preferable.
Executive Functioning in the Schools: Perspectives from Occupational Therapists

ABSTRACT Awareness of executive functioning and its relevance to both occupational participation and special education is expanding. This study describes how school-based occupational therapists address executive functioning in practice and determined if this differs from traditional areas. Fourteen occupational therapists from four districts in Michigan completed the 36-item online survey consisting of closed and open-ended questions. A majority of these participants agreed that executive functioning impacts school function and occupational therapists should address it in school; yet, only 33% provided intervention using this lens and 77% indicated this as the area they feel least prepared to address in school-based practice. Executive function practice significantly differed from handwriting (p < .05), sensory (p < .01), and fine motor competency (p < .01); fine motor and sensory evaluation (p < .05); and handwriting intervention (p < .05). Participants described their role with executive functioning as collaborative, supplemental to enhance participation, and applicable to functional organization tasks. Although some occupational therapists are embracing an occupation-based process explicitly considering executive functioning, a majority need continued education, role clarity, and advocacy to more intentionally align their team’s services with emerging best practice.
A Unified Open and Closed-Source Software Requirements Dataset

Requirements Engineering (RE) has proven to be an important factor for the success of a software project. The common use of natural language for writing requirements often results in problems that should be detected and avoided early. For this reason, we want to build automatic tools to support the process of specifying requirements using Deep Learning (DL). However, training robust DL models is very data-intensive and the RE community still suffers from a lack of large-scale requirement datasets that are easy to use. Therefore, the goal of this study is to create such a dataset that can be used for various tasks in the RE domain. To do this, we collect functional and non-functional requirements from a large number of both open and closed source software projects and combine them into a unified dataset using a simple data format. We then train a DL model for automatically classifying functional and non-functional requirements to show the potential of our dataset for training efficient DL models. We compare its performance with a state-of-the-art model and students at the University of Stuttgart. We also examine the differences between the open and closed source requirements in our dataset and compare the textual corpus of our dataset with common English datasets and corpora. Our studies showed that our model outperforms both the state-of-the-art model and most of the students. Further, we observed remarkable differences between the open and closed source requirements and found that our requirements use a unique vocabulary compared to common English texts.
Financial institutions depth and growth in Nepal: Sensitivity to the choice of depth proxy

Abstract This paper examines the long-run and short-run growth effects of financial institutions depth in Nepal along with the sensitivity to the choice of proxy representing financial depth. Using annual time-series data for the period from 1980 till 2019, obtained from Quarterly Economic Bulletins published by Nepal Rastra Bank, the study employed autoregressive distribute lag (ARDL) model with bounds testing procedures to examine cointegration. Domestic credit to private sector, broad money supply, total deposits and financial institution’s assets are used as proxies for financial institutions depth as indicated by World Bank. Real GDP is used to measure economic growth and the influence of macroeconomic environment is accounted by inflation and trade openness. The bounds tests found cointegration in economic growth functions and the regression results revealed that domestic credit to private sector performed better than other indicators in terms of its significant contribution to economic growth both in the long-run and the short-run. Money supply and financial deposits show significant positive contribution to growth in the long-run. The positive relationship of financial depth indicators with economic growth also supports the supply-leading (finance-led-growth) hypothesis in the long-run. Policies must be aimed at efficient allocation of affordable credit to profitable projects for short-run and long-run growth. Expansionary fiscal and monetary policy and long-term deposits are highly desirable for the long-run growth in Nepal.
Advances in Endothelial Cell Biology: From Knowledge to Control

The aim of this Special Issue is to provide an overview of recent investigations in the field of endothelial cell (EC) biology that advance our understanding of the molecular mechanisms that trigger normal EC functions and dysfunctions in pathologies and to demonstrate how improved knowledge of EC biology may lead to the discovery of novel molecular diagnostic technologies and targeted therapeutics [. ].
Defects in bent-core liquid crystals

Topological defects and defect phases of rigid and flexibly bent-shaped liquid crystals are reviewed with emphasis on how they are affected by the departure of molecular shapes from a simple rod. The review discusses defects in bent-core uniaxial and hypothetical biaxial nematics, twist-bend nematic, and various frustrated layered bent-core liquid crystals, such as twist-grain boundary phase, nanoscale helical nanofilament phase, and the so-called B7 textures with helical ribbons.
Feasibility and Effectiveness of a Psychosis‐Specific Intensive Outpatient Program

Objective Intensive outpatient programs (IOPs) are rarely designed specifically to treat psychosis. In 2016 UCLA established the Thought Disorders Intensive Outpatient Program (TD IOP), combining a time‐limited, group‐based intervention called cognitive behavioral social skills training (CBSST) and medication management to treat individuals with psychosis. The purpose of this study is to assess the feasibility of developing an IOP for individuals with psychosis and the effectiveness of the program in improving psychotic symptom severity. Methods Adults were referred to the TD IOP from inpatient and outpatient settings. Programming included 3 hours of CBSST and 6 hours of additional groups weekly as well as individual psychiatry and social work services. Primary outcomes were symptom changes as measured at intake and discharge by the Clinician‐Rated Dimensions of Psychosis Symptom Severity scale. Program feedback was solicited from a small subset of patients. Results Of the 92 enrolled subjects, 71 completed the program (77.2%). Average length of stay was 52 ± 30 days across all enrolled. Participants showed significant (p < 0.05) improvement with small‐moderate effect sizes across five of eight psychosis symptom domains (hallucinations, delusions, disorganized speech, depression, and mania). Patient‐reported program satisfaction was high (86.6 ± 12.7 score, range 0–100). Conclusions The current study indicates that targeted treatment for psychosis is successful within an IOP framework, with minimal additional training required for Master's level clinicians. Participants demonstrated significant symptomatic relief from group‐based, time‐limited treatment. Further work is needed to determine the full range of program benefits on patient well‐being and illness morbidity.
Isotopic signatures of biotic and abiotic N2O production and consumption in the water column of meromictic, ferruginous Lake La Cruz (Spain)

Lakes can be important sources of the potent greenhouse gas nitrous oxide (N2O) to the atmosphere, but to what extent abiotic processes may contribute to lacustrine N2O production remains uncertain. We assessed pathways of N2O production and reduction in the water column of meromictic and iron‐rich Lake La Cruz, Spain, including chemodenitrification‐induced N2O formation via the reaction of reactive nitrogen (N) (e.g., NO2− ) with ferrous iron (Fe[II]). In the oxic waters (~8–10 m), N2O concentrations above atmospheric equilibrium were associated with comparatively low δ15N‐N2O, high δ15N‐NH4+ , and high N2O 15N‐site‐preference (SP) values (up to ~29‰), suggesting N2O production by nitrification. N2O concentrations were highest (23–33 nM) near the depth of oxygen depletion (~11–14.5 m), likely due to production by nitrifier denitrification and/or denitrification, as indicated by decreasing SP values (as low as 12‰). Further below (~14.5–17 m), N2O consumption was indicated by increasing SP values and a δ18O‐vs.‐δ15N relationship (1.8–2.9) typical for stand‐alone N2O reduction. The coupled N‐vs.‐O isotope signatures thus highlight the spatial, redox‐dependent separation of incomplete and complete denitrification. In incubations with sterile‐filtered lake water and 15N‐labeled or unlabeled substrate, NO2− was reduced by Fe2+ to N2O, even at low nitrite concentrations (5 μM NO2− ). In the water column, the spatial separation of NO2− and Fe(II) during our samplings appears to preclude elevated rates of chemodenitrification, but during periods of overlapping NO2− and Fe(II) in Lake La Cruz, and potentially in other lakes, its distinct N2O δ18O‐vs.‐δ15N relationship of ~1 : 1, as experimentally determined, could help to detect it.
Screen Printed, Skin-compliant Sensors for Mouse Electrocardiography

Advances in flexible electronic materials have seen the emergence of ultra-thin epidermal sensors for monitoring human electrocardiography (ECG), with some designs only micrometers in thickness. Application of this technology to mice could refine current pre-clinical protocols by enabling more humane, non-invasive monitoring systems. This work characterises the electrical properties and skin-conformity of three screen printed Ag/AgCl ECG electrode designs for mice. Specifically, we examine substrates of temporary tattoo paper and 25 µm thick polyester, which attach to the skin using conductive paste or a polyurethane-film (PU). This work demonstrates how skin-conforming sensors can collect acceptable quality mouse ECG signals. Whilst electrical characterisation suggests that probes without conductive paste are reliant on capacitive coupling, where interface adhesives and the mouse’s thin stratium corneum act as a dielectric. Finally we examine skin conformity with histological imaging, revealing tattoo substrate and PU to be considerably more compliant than polyester. This opens up discussion into which materials would be most suitable in developing an ECG interface for free-moving mice.
Gene Expression Profiling in Abdominal Aortic Aneurysms

Gene expression profiling of abdominal aortic aneurysms (AAA) indicates that chronic inflammatory responses, active matrix metalloproteinases, and degradation of the extracellular matrix components are involved in disease development and progression. This study investigates intra- and interpersonal RNA genome-wide expression profiling differences (Illumina HumanHT-12, BeadCHIP expression) of 24 AAA biopsies from 12 patients using a single gene and pathway (GeneOntology, GO enrichment) analysis. Biopsies were collected during open surgical AAA repair and according to prior finite element analysis (FEA) from regions with the highest and lowest wall stress. Single gene analysis revealed a strong heterogeneity of RNA expression parameters within the same and different AAA biopsies. The pathway analysis of all samples showed significant enrichment of genes from three different signaling pathways (integrin signaling pathway: fold change FC 1.63, p = 0.001; cholecystokinin receptor pathway: FC 1.60, p = 0.011; inflammation mediated by chemokine signaling pathway: FC 1.45, p = 0.028). These results indicate heterogeneous gene expression patterns within the AAA vascular wall. Single biopsy investigations do not permit a comprehensive characterization of activated molecular processes in AAA disease.
Crosstalk between the Circadian Clock and Histone Methylation

The circadian clock and histone modifications could form a feedback loop in Arabidopsis; whether a similar regulatory mechanism exists in rice is still unknown. Previously, we reported that SDG724 and OsLHY are two rice heading date regulators in rice. SDG724 encodes a histone H3K36 methyltransferase, and OsLHY is a vital circadian rhythm transcription factor. Both could be involved in transcription regulatory mechanisms and could affect gene expression in various pathways. To explore the crosstalk between the circadian clock and histone methylation in rice, we studied the relationship between OsLHY and SDG724 via the transcriptome analysis of their single and double mutants, oslhy, sdg724, and oslhy sdg724. Screening of overlapped DEGs and KEGG pathways between OsLHY and SDG724 revealed that they could control many overlapped pathways indirectly. Furthermore, we identified three candidate targets (OsGI, OsCCT38, and OsPRR95) of OsLHY and one candidate target (OsCRY1a) of SDG724 in the clock pathway. Our results showed a regulatory relationship between OsLHY and SDG724, which paved the way for revealing the interaction between the circadian clock and histone H3K36 methylation.
Effects of spatial augmented reality assistance on the efficiency of prefabricating timber frame walls

ABSTRACT Assistance systems have the potential to support workers in various assembly tasks. Especially in mass customized prefabrication, the correct objects need to be selected and positioned accurately. Using conventional paper plans as assembly guidance, skilled workers need to spend precious time carefully reading plans for the individually designed elements. Augmented reality (AR) systems can help to integrate information for assembly tasks directly into the work environment, which should improve time efficiency and error rates. However, AR systems are often not ergonomic or accurate enough (e.g. smartglasses) or expensive (e.g. laser projectors). In the present study, the effect of a simple projection based spatial augmented reality (SAR) system was studied for building prefabricated wall elements under laboratory conditions, using printed CAD drawings as reference. Each subject built a timber frame wall element with dimensions close to reality. Using the SAR system, the completion times were reduced by nearly 50%, the error rate of subjects with a low experience level decreased and the reported task load measured according to the NASA raw task load index using the SAR system was significantly lower.
Molding process and properties of continuous carbon fiber three-dimensional printing

Currently, carbon fiber composite has been applied in the field of three-dimensional printing to produce the high-performance parts with complex geometric features. This technique comprise both the advantages of three-dimensional printing and the material, which are light weight, high strength, integrated molding, and without mold, and the limitation of model complexity. In order to improve the performance of three-dimensional printing process using carbon fiber composite, in this article, a novel molding process of three-dimensional printing for continuous carbon fiber composites is developed, including the construction of printing material, the design of printer nozzle, and the modification of printing process. A suitable structure of nozzle on the printer is adjusted for the continuous carbon fiber composites. For the sake of ensuring the continuity of composited material during the processing, a cutting algorithm for jumping point is proposed to improve the printing path during process. On this basis, the experiment of continuous carbon fiber composite is performed and the mechanical properties of the printed test samples are analyzed. The results show that the tensile strength and bending strength of the sample printed by polylactic acid–continuous carbon fiber composites increased by 204.7% and 116.3%, respectively compared with pure polylactic acid materials, and those of the sample printed by nylon–continuous carbon fiber composites increased by 301.1% and 17.4% compared with pure nylon materials, and those of test sample by nylon–continuous carbon fiber composites under the heated and pressurized treatment increased by 383.6% and 233.2% compared with pure nylon material.
Telework Distress and Eustress Among Chinese Teleworkers

This study investigates antecedents to and outcomes of two stress reactions, telework distress (detrimental stress), and telework eustress (beneficial stress) using a model derived from an integration of the transactional model of stress with the job-demands and resources model. The model includes a person antecedent (resilience), and three environment antecedents (work-family conflict, work overload, and autonomy). These factors should influence experienced distress and eustress, which, in turn, affect telework outcomes (telework satisfaction, exhaustion, perceived performance, and perceived productivity. The model is evaluated using a sample of 329 Chinese teleworkers. This study findings indicate that resilience, work-family conflict, and work overload affect experienced distress, while resilience and autonomy affect experienced eustress. Experienced distress influenced satisfaction, exhaustion, and perceived performance; eustress had effects on all four outcomes. Interestingly, resilience had the largest total effect sizes on telework outcomes.
Electrospun Core (HPMC–Acetaminophen)–Shell (PVP–Sucralose) Nanohybrids for Rapid Drug Delivery

The gels of cellulose and its derivatives have a broad and deep application in pharmaceutics; however, limited attention has been paid to the influences of other additives on the gelation processes and their functional performances. In this study, a new type of electrospun core–shell nanohybrid was fabricated using modified, coaxial electrospinning which contained composites of hydroxypropyl methyl cellulose (HPMC) and acetaminophen (AAP) in the core sections and composites of PVP and sucralose in the shell sections. A series of characterizations demonstrated that the core–shell hybrids had linear morphology with clear core–shell nanostructures, and AAP and sucralose distributed in the core and shell section in an amorphous state separately due to favorable secondary interactions such as hydrogen bonding. Compared with the electrospun HPMC–AAP nanocomposites from single-fluid electrospinning of the core fluid, the core–shell nanohybrids were able to promote the water absorbance and HMPC gelation formation processes, which, in turn, ensured a faster release of AAP for potential orodispersible drug delivery applications. The mechanisms of the drug released from these nanofibers were demonstrated to be a combination of erosion and diffusion mechanisms. The presented protocols pave a way to adjust the properties of electrospun, cellulose-based, fibrous gels for better functional applications.
Association between Occupation and Cervical Disc Degeneration in 1211 Asymptomatic Subjects

Magnetic resonance imaging (MRI) system has frequently observed degenerative changes in the cervical discs of healthy subjects. Although there are concerns regarding the link between an individual’s occupation and intervertebral disc degeneration (IDD) in the cervical spine, whether the occupation affects IDD is still not clear. This study aimed to evaluate the occupation and IDD interplay using cervical spine MRI among a cohort of healthy individuals, and to evaluate any association between the type of labor and IDD. Using MRI, we prospectively measured at every level, the anteroposterior (AP) intervertebral disc diameter and disc height, in a cohort of 1211 healthy volunteers (606 (50%) male; mean age, 49.5 years). Using a minimum of 100 male and female each from the third to eighth decades of age (20–79 years), IDD was evaluated based on the modified Pfirrmann classification system to derive a disc degeneration score (DDS). We also measured the AP diameters of disc protrusion and of the dural sac as well as the spinal cord. The overall DDS and number of disc protrusions increased with age. Among 11 occupations, there were no significant differences in AP diameter of the dural sac as well as the spinal cord. For the four labor types (heavy object handling, same position maintenance, cervical extension position, and cervical flexion position), there were no significant differences in overall DDS and number of disc protrusions, with or without work. Also, among the four labor types, there were no significant differences in the AP diameter of the dural sac as well as the spinal cord. In this cross-sectional survey of cervical spine MRI data among healthy adult volunteers, occupation and type of labor might have no effect on IDD in the cervical spine.
There's No Such Thing as Creativity

Most people (including creativity researchers) act as if they believe that creativity is not simply a useful category or label but a real thing with its own essence (just as Plato would argue that an ideal triangle has an essence that is shared with all actual triangles). Most people (including creativity researchers) also believe that there is a set of general creativity-relevant skills that can be applied to most problems in ways that will lead to more creative outcomes. Creativity research now calls these beliefs into question. A domain-general misunderstanding of the nature of creativity-relevant skills and the equally mistaken belief that creativity exists independently of actual creative things and ideas have together hindered creativity theory, research, assessment, and training. A more domain-specific and nominalist understanding of creativity will free creativity researchers to make progress in areas where it is currently stymied.
Mental Health during COVID-19 Pandemic: Qualitative Perceptions among Lithuanian Adolescents

Background: Since the COVID-19 pandemic emerged, humanity has had to face unprecedented change in daily routines. Therefore, the pandemic has also had an impact on mental health. Most of the literature analyzes adult experiences during the COVID-19 pandemic, while the youth is less investigated. The purpose of this study was to reveal adolescent experiences during COVID-19. Methods: This qualitative study consisted of 19 adolescents from 11–17 years old. Semi-structured in-depth interviews were conducted, and thematic analysis was applied. Results: Five themes were identified: ambivalent feelings; daily routine changes; disappointment with distance education; coping strategies; and discoveries. Conclusion: The study revealed adolescents’ mostly negative feelings such as sadness, anger, loneliness, or boredom. They shared about frustrating daily routine changes and shifting to a distance education mode that was quite limited in effectiveness and convenience. Nonetheless, communication with family, peers, pets, active leisure, and favorite activities helped them to cope with the difficulties during COVID-19. During this period, adolescents had more free time for themselves and personal growth, found new activities, or improved some relationships. Overall, the COVID-19 pandemic had mostly negative side effects, and regardless of positive experiences, it was mainly considered by adolescents as an adversity for their mental health.