Miracle-dz/UniFAR-FTUs huggingface dataset:
Heterochrony in bourgueticrinid sea-lilies at the Cretaceous/Tertiary boundary

Abstract The Cretaceous/Tertiary boundary event exerted a deep influence on the life of the benthic invertebrates in the Danish Basin. The density and taxonomic diversity of most groups fell abruptly and the lowermost Danian strata are almost barren of invertebrates. The echinoderms, and among them in particular crinoids of the family Bourgueticrinidae, are the only group that deviates form this general pattern and show an increase in the strata immediately above the boundary. This exceptional development is accompanied by a heterochronic change in which the largest element of the bourgueticrinid theca, the proximale, is lost by paedomorphosis (neoteny). In the Late Cretaceous bourgueticrinids the proximale is formed during early ontogeny by the incorporation of a columnal element into the theca, and the addition of new columnals stops once the proximale is formed. The paedomorphic change and the elimination of the proximale allow, in principle, columnals to be added throughout life. This new development is probably the result of a selection for longer stems. It is successful from the very beginning and Democrinus maximus, the earliest bourgueticrinid species in the Danish Basin without a proximale, makes up about 90% of the crinoid fauna in the lowermost Danian deposits.
Splenic marginal zone lymphoma with monoclonal IgG: A case report

Rationale: Splenic marginal zone lymphoma (SMZL), an indolent small B-cell lymphoma, is uncommon, and part of the patients exist plasmocytic differentiation and secrete monoclonal paraproteins including IgM predominantly. SMZL with monoclonal IgG is rarer. Patient concerns: We report a case of SMZL (49-year-old, male) with monoclonal IgG, MYD88L265P mutation and hepatitis B virus infection. Diagnoses: The patient was presented to our hospital with aggravating complaints of dizziness, fatigue, postprandial abdominal distension, and night sweats. The diagnosis was confirmed by clinical manifestations, immunophenotype, bone marrow pathology. Interventions: The patient received rituximab-based chemotherapy and sequential ibrutinib in combination with entecavir. Outcomes: After 1 year of follow-up, his blood routine examination had returned to normal with normal level of albumin and significantly lower globulin than before, and the spleen was of normal size. Lessons: We conclude that rituximab-based chemotherapy is the main treatment option for the patients with SMZL, and Bruton’s tyrosine kinase inhibitor has also shown beneficial efficacy.
Recreation suitability analysis: application in protected and non-protected areas.

The influence of tourism in some territories should constitute a priority objective in environmental planning and management. Indeed, this activity tends to occur in areas that are clearly fragile in the socio-ecological sense. Sensible development of tourism involves the correct use of natural resources in protected areas and in many non-protected areas containing particularly sensitive natural and cultural values. Methodological approaches for recreational planning should include an appraisal of the natural, visual and cultural values of the landscape, visitors’ preferences and demands, and an analysis of the relationship between landscape supply and demand. In this paper we apply a model that relates natural values and visitor preferences for suitable management of both protected and non-protected natural areas in the surrounding territories. To this end: i) we characterised the natural and cultural landscapes of eastern Andalucia (Spain), considering characteristics of the territory that are potentially attractive for tourism and ii) we typified the visitors. We analysed the demand for tourism by means of questionnaires filled in by the visitors and which contained aspects relating to their preferences according to the features of the landscape. Thus, we obtained different types of visitors with different attitudes and perceptions in relation to the territory. The model used enabled us to establish the spatial correspondence between the different zones of the territory and demand according to visitors’ preferences. The procedure employed allowed for the design of maps at different scales showing the distribution of preferences and the possible areas to be visited by the different types of tourists and the degree of satisfaction these obtain. This Tourism and Natural Protected Areas 71 www.witpress. com, ISSN 1755-8336 (on-line) WIT Transactions on State of the Art in Science and Engineering, Vol 70, © 2013 WIT Press doi:10.2495/978-1-84564-810-7/007 provides a useful reference for the design of a rational management system for tourism in the territory, inside and outside protected natural areas.
Ramping Dynamics in the Frontal Cortex Unfold Over Multiple Timescales During Motor Planning

Plans are formulated and refined over the period leading to their execution, ensuring that the appropriate behavior is enacted at just the right time. While existing evidence suggests that memory circuits convey the passage of time through diverse neuronal responses, it remains unclear whether the neural circuits involved in planning behavior exhibit analogous temporal dynamics. Using publicly available data, we analyzed how activity in the frontal motor cortex evolves during motor planning. Individual neurons exhibited diverse ramping activity throughout a delay interval that preceded a planned movement. The collective activity of these neurons was useful for making temporal predictions that became increasingly precise as the movement time approached. This temporal diversity gave rise to a spectrum of encoding patterns, ranging from stable to dynamic representations of the upcoming movement. Our results indicate that neural activity unfolds over multiple timescales during motor planning, suggesting a shared mechanism in the brain for processing temporal information related to both past memories and future plans.
Kondisi Perikanan Tangkap Di Wilayah Pengelolaan Perikanan (WPP) Indonesia

Aktivitas usaha perikanan tangkap umumnya tumbuh dikawasan sentra nelayan dan pelabuhan perikanan yang tersebar di wilayah pesisir Indonesia. Pengelolaan perikanan di Indonesia terbagi menjadi 10 wilayah yang disebut dengan Wilayah Pengelolaan Perikanan (WPP) yaitu: Selat Malaka, Laut Cina Selatan, Laut Jawa, Laut Flores dan Selat Makasar, Laut Banda, Laut Arafura, Teluk Tomini dan Laut Maluku, Samudra Pacifik dan Laut Sulawesi, Samudra Hindia sebelah barat Sumatera serta Samudra Hindia sebelah selatan Jawa. Tujuan penelitian ini adalah mengetahui perkembangan perikanan tangkap di setiap WPP. Perkembangan perikanan tangkap di 10 WPP belum merata dan masih ada beberapa WPP yang over fished untuk beberapa jenis ikan, yaitu ikan demersal di WPP Selat Malaka; udang di WPP Selat Malaka, Laut Flores dan Selat Makasar, serta Laut Arafura; ikan pelagis kecil di WPP Laut Cina Selatan dan Laut Jawa; ikan pelagis besar di Samudra Pasifik dan Laut Sulawesi. Untuk WPP yang masih bisa dikembangkan adalah Teluk tomini dan Laut Maluku untuk ikan demersal; Laut Cina Selatan untuk Udang; Laut Flores dan Selat Makassar, Laut Banda, Laut Arafura, Teluk tomini dan Laut Maluku, serta Samudra Hindia sebelah selatan Jawa untuk ikan pelagis kecil; Laut Banda untuk pelagis besar. Komitmen dalam pengelolaan perikanan yang bertanggungjawab merupakan salah satu hal yang membuat perkembangan perikanan tangkap Indonesia cenderung tidak merata. Komitmen tersebut harus diwujudkan dengan mengendalikan perikanan tangkap untuk menjamin kelestarian sumberdaya berdasarkan code of conduct for responsible fisheries (CCRF) yang dikeluarkan oleh FAO.
CoR 2 Ds : Context-Rooted Rotatable Draggables for Tabletop Interaction

We present a new popup widget, called CoR2Ds (Context-Rooted Rotatable Draggables), designed for multi-user direct-touch tabletop environments. CoR2Ds are interactive callout popup objects that are visually connected (rooted) at the originating displayed object by a semi-transparent colored swath. CoR2Ds can be used to bring out meanus, display drilled-down or off-screen ancillary data such as metadata and attributes, as well as instantiate tools. CoR2Ds can be freely moved, rotated, and re-oriented on a tabletop display surface by fingers, hands, pointing devices (mice) or marking devices (such as a stylus or light pen). CoR2Ds address five issues for interaction techniques on interactive tabletop display surfaces: occlusion, reach, context on a cluttered display, readability, and concurrent/coordianted multi-user interaction. In this paper, we present the design, interaction and implementation of CoR2Ds. We also discuss a set of current usage
WARNING MESSAGE DISSEMINATION IN VANETS USING SUMO AND MOVE

In Recent survey VANETs have many possible architectures, algorithms and protocols About traffic safety applications and warning message dissemination which are having very less time to reach as well as for highest number of possible vehicles.so in past we have manyapproaches to disseminate the warning messages upon multi hop wireless networks with lesstime consumption.our proposed technique used in urban areas where the vehicle density is high and technique for the improvement of message warning dissemination.in this paper for simulation we used one of the routing protocol i.e AODV which allow the usersto generate real world mobility models for VANET simulations the tools required are Ns-2, SUMO and MOVE. MOVE is a tool for open source traffic simulator and the output of MOVE is an real world mobility model. The broadcasting is done in NS-2 we adopt the best technique to eliminate the broadcast storm problem. and to disseminate messages very fastly.
Analisis Perbandingan Kinerja Protokol Routing DSDV dan OLSR Untuk Perubahan Kecepatan Mobilitas pada Standar IEEE 802.11ah

Dewasa ini, teknologi informasi yang praktis dan efisien sangatlah dibutuhkan. Jaringan ad hoc merupakan teknologi wireless LAN (WLAN) yang tidak membutuhkan suatu infrastruktur seperti base station pada jaringannya. Akan tetapi, teknologi wireless sering kali memiliki keterbatasan resource. Standar IEEE 802.11ah didesain untuk bekerja pada frekuensi sub – 1 GHz, jangkauan transmisinya mencapai 1 Km, konsumsi daya yang rendah, serta dapat melayani ribuan station untuk sebuah access point. Pada penelitian ini telah membandingkan protokol routing DSDV dan OLSR pada standar IEEE 802.11ah dengan menggunakan NS 3. Sedangkan parameter perbandingan yang digunakan adalah throughput, packet delivery ratio, rata – rata delay, dan konsumsi energi. Berdasarkan hasil yang didapat, protokol routing OLSR memiliki kinerja yang lebih baik dibandingkan protokol routing DSDV pada skenario perubahan kecepatan. Nilai rata – rata throughput untuk OLSR adalah 28400 Bps sedangkan untuk DSDV adalah 2934 Bps. Nilai rata – rata PDR untuk OLSR adalah 14,582 % sedangkan untuk DSDV adalah 2,7 %. Nilai rata – rata delay untuk OLSR adalah 0,04453994 s sedangkan untuk DSDV adalah 0,6261986 s. Sedangkan rasio perbandingan untuk konsumsi energi antara protokol routing OLSR dan DSDV adalah 1,48 % untuk skenario perubahan kecepatan.
Chapter 19. Protecting and Perpetuating Papahānaumokuākea: Involvement of Native Hawaiians in Governance of Papahānaumokuākea Marine National Monument

Papahānaumokuākea Marine National Monument encompasses the Northwestern Hawaiian Islands (NWHI), or approximately two-thirds of the Hawaiian Archipelago and of what was once recognized as the Hawaiian Kingdom. Since nature and culture are considered to be one and the same by Native Hawaiians, the protection of one of the last nearly pristine, natural, marine ecosystems in the archipelago equates to preserving the living Hawaiian culture. Respecting Native Hawaiian traditions and values, and providing an effective degree of participation in the protection and stewardship of Papahānaumokuākea provides Native Hawaiians with opportunities to maintain ancestral connections to the NWHI and to continue to implement the resource management skills that allowed them to flourish prior to Western contact. Native Hawaiians are the algae that are in a symbiotic relationship with their archipelago, all of the elements of which are related to the coral polyp. Keywords:Hawaiian Archipelago; Hawaiian Kingdom; marine ecosystem; Northwestern Hawaiian Islands (NWHI); Papahānaumokuākea Marine National Monument
Novel SiC Trench MOSFET with Improved Third-Quadrant Performance and Switching Speed

A SiC double-trench MOSFET embedded with a lower-barrier diode and an L-shaped gate-source in the gate trench, showing improved reverse conduction and an improved switching performance, was proposed and studied with 2-D simulations. Compared with a double-trench MOSFET (DT-MOS) and a DT-MOS with a channel-MOS diode (DTC-MOS), the proposed MOS showed a lower voltage drop (VF) at IS = 100 A/cm2, which can prevent bipolar degradation at the same blocking voltage (BV) and decrease the maximum oxide electric field (Emox). Additionally, the gate–drain capacitance (Cgd) and gate–drain charge (Qgd) of the proposed MOSFET decreased significantly because the source extended to the bottom of the gate, and the overlap between the gate electrode and drain electrode decreased. Although the proposed MOS had a greater Ron,sp than the DT-MOS and DTC-MOS, it had a lower switching loss and greater advantages for high-frequency applications.
Hypoglycemia Unawareness—A Review on Pathophysiology and Clinical Implications

Hypoglycemia is a particular problem in people with diabetes while it can also occur in other clinical circumstances. Hypoglycemia unawareness describes a condition in which autonomic and neuroglycopenic symptoms of hypoglycemia decrease and hence are hardly perceivable. A failure to recognize hypoglycemia in time can lead to unconsciousness, seizure, and even death. The risk factors include intensive glycemic control, prior episodes of severe hypoglycemia, long duration of diabetes, alcohol consumption, exercise, renal failure, and sepsis. The pathophysiological mechanisms are manifold, but mainly concern altered brain glucose sensing, cerebral adaptations, and an impaired hormonal counterregulation with an attenuated release of glucagon, epinephrine, growth hormone, and other hormones, as well as impaired autonomous and neuroglycopenic symptoms. Physiologically, this counterregulatory response causes blood glucose levels to rise. The impaired hormonal counterregulatory response to recurrent hypoglycemia can lead to a vicious cycle of frequent and poorly recognized hypoglycemic episodes. There is a shift in glycemic threshold to trigger hormonal counterregulation, resulting in hypoglycemia-associated autonomic failure and leading to the clinical syndrome of hypoglycemia unawareness. This clinical syndrome represents a particularly great challenge in diabetes treatment and, thus, prevention of hypoglycemia is crucial in diabetes management. This mini-review provides an overview of hypoglycemia and the associated severe complication of impaired hypoglycemia awareness and its symptoms, pathophysiology, risk factors, consequences, as well as therapeutic strategies.
Quantification of oxygen consumption in head and neck cancer using fluorescent sensor foil technology

Introduction Head and neck squamous cell carcinoma (HNSCC) patients suffer from frequent local recurrences that negatively impact on prognosis. Hence, distinguishing tumor and normal tissue is of clinical importance as it may improve the detection of residual tumor tissue in surgical resection margins and during imaging-based surgery planning. Differences in O2 consumption (OC) can be used to this aim, as they provide options for improved surgical, image-guided approaches. Methods In the present study, the potential of a fluorescent sensor foil-based technology to quantify OC in HNSCC was evaluated in an in vitro 3D model and in situ in patients. Results In vitro measurements of OC using hypopharyngeal and esophageal cell lines allowed a specific detection of tumor cell spheroids embedded together with cancer-associated fibroblasts in type I collagen extracellular matrix down to a diameter of 440 µm. Pre-surgery in situ measurements were conducted with a handheld recording device and sensor foils with an oxygen permeable membrane and immobilized O2-reactive fluorescent dyes. Lateral tongue carcinoma and carcinoma of the floor of the mouth were chosen for analysis owing to their facilitated accessibility. OC was evaluated over a time span of 60 seconds and was significantly higher in tumor tissue compared to healthy mucosa in the vicinity of the tumor. Discussion Hence, OC quantification using fluorescent sensor foil-based technology is a relevant parameter for the differentiation of tumor tissue of the head and neck region and may support surgery planning.
Chemoprevention of esophageal adenocarcinoma in a rat surgical model by a cysteinyl leukotriene receptor‑1 antagonist

Reflux of gastroduodenal contents into the esophagus leads to the development of esophagitis and inflammation-associated pathologies, such as Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). The role of the lipoxygenase (LOX) pathway in carcinogenesis has been recently reported; however, its involvement in esophageal carcinogenesis remains unclear. To address this, the present study investigated the potential of pranlukast, a cysteinyl leukotriene receptor-1 antagonist, to suppress the progression of BE and EAC in a rat duodenogastroesophageal reflux (DGER) model. Male Wistar rats that underwent DGER were divided into two groups. One group was fed commercial chow (control group), and the other was fed experimental chow containing pranlukast (pranlukast group). The rats were sacrificed at 10, 20, 30 and 40 weeks after surgery, and their esophagi were examined. Expression levels of 5-LOX, CD68, IL-8, VEGF and Ki-67 were investigated using immunohistochemistry, and apoptosis was analyzed using the TUNEL method. In the pranlukast group, esophagitis was milder, and the incidence of BE and EAC was significantly lower (P<0.05) compared with that in the control group at 40 weeks after surgery. The number of cells positive for IL-8 and VEGF were significantly lower in the pranlukast group compared with the control group. Proliferative activity was also lower in the pranlukast group compared with the control group (P<0.05). Pranlukast treatment increased apoptosis (P<0.05). Overall, Pranlukast suppressed esophageal carcinogenesis in a rat DGER model, decreasing inflammatory cytokines such as IL-8 and VEGF.
Water quality of Wenchi Crater Lake in Ethiopia

Determination of physico-chemical properties of water samples from Wenchi Crater Lake in Ethiopia was carried out. Selected heavy metals in water, sediment, and plant samples from the lake were also comparatively determined. The results indicated that most general physico-chemical properties of the lake water fell within those recommended for drinking water. However, the lake water was found to be high in some heavy metals, which also accumulated in the sediment. Bioconcentration of these metals was also observed in the plant samples.
Fear of Cancer Progression: A Comparison between the Fear of Progression Questionnaire (FoP-Q-12) and the Concerns about Recurrence Questionnaire (CARQ-4)

As cancer patients often suffer from fear of cancer progression (FoP), valid screening for FoP is of high relevance. The aims of this study were to test psychometric properties of two FoP questionnaires, to determine their relationship to other anxiety-related constructs, and to analyze the impact of sociodemographic and clinical factors on the FoP. Our sample consisted of n = 1733 patients with mixed cancer diagnoses. For measuring FoP, the Fear of Progression questionnaire (FoP-Q-12) and the Concerns About Cancer Recurrence Questionnaire (CARQ-4) were used. The mean scores of the FoP-Q-12 and the CARQ-4 were 30.0 ± 10.4 and 16.1 ± 10.8, respectively, indicating relatively high levels of FoP. Both questionnaires showed excellent internal consistency coefficients, α = 0.895 and α = 0.915, respectively. The correlation between the two FoP questionnaires was r = 0.72. Female patients reported more FoP than male patients (d = 0.84 and d = 0.54, respectively). There was a nonlinear age dependency of FoP, with an increase found in the age range from 18 to 50 years and a decrease in the older age range. Radiation, chemotherapy, and antibody therapy, but not surgery, lead to an increase in FoP. Both questionnaires show good psychometric properties and can be recommended for use in an oncological routine. Female patients and patients in the middle-age range deserve special attention from healthcare providers.
Perturbations in gut and respiratory microbiota in COVID-19 and influenza patients: a systematic review and meta-analysis

Objectives Coronavirus disease-19 (COVID-19)/influenza poses unprecedented challenges to the global economy and healthcare services. Numerous studies have described alterations in the microbiome of COVID-19/influenza patients, but further investigation is needed to understand the relationship between the microbiome and these diseases. Herein, through systematic comparison between COVID-19 patients, long COVID-19 patients, influenza patients, no COVID-19/influenza controls and no COVID-19/influenza patients, we conducted a comprehensive review to describe the microbial change of respiratory tract/digestive tract in COVID-19/influenza patients. Methods We systematically reviewed relevant literature by searching the PubMed, Embase, and Cochrane Library databases from inception to August 12, 2023. We conducted a comprehensive review to explore microbial alterations in patients with COVID-19/influenza. In addition, the data on α-diversity were summarized and analyzed by meta-analysis. Results A total of 134 studies comparing COVID-19 patients with controls and 18 studies comparing influenza patients with controls were included. The Shannon indices of the gut and respiratory tract microbiome were slightly decreased in COVID-19/influenza patients compared to no COVID-19/influenza controls. Meanwhile, COVID-19 patients with more severe symptoms also exhibited a lower Shannon index versus COVID-19 patients with milder symptoms. The intestinal microbiome of COVID-19 patients was characterized by elevated opportunistic pathogens along with reduced short-chain fatty acid (SCFAs)-producing microbiota. Moreover, Enterobacteriaceae (including Escherichia and Enterococcus) and Lactococcus, were enriched in the gut and respiratory tract of COVID-19 patients. Conversely, Haemophilus and Neisseria showed reduced abundance in the respiratory tract of both COVID-19 and influenza patients. Conclusion In this systematic review, we identified the microbiome in COVID-19/influenza patients in comparison with controls. The microbial changes in influenza and COVID-19 are partly similar.