Miracle-dz/UniFAR-FTUs huggingface dataset:
Where you Export Matters

Economic complexity theory deepens our understanding of export diversification. However, it relies on aggregated data which might disguise important details. In particular, these data do not take information on importers into account even though this information can provide new insights about the pace of economic complexity evolution in a particular economy. The paper introduces these new insights by incorporating more detailed export data into analysis. I find that wealthier economies not only tend to export more sophisticated products, but also sell them to richer destinations. I discuss the case of Russia which seeks to become a more complex economy and gain technological ­sovereignty by implementing reindustrialization policy. However, Russian complex products rarely conquer richer markets and are better known to Russia’s geographic neighbors. Our findings suggest that such a pattern of reindustrialization might not be promising as long as a higher level of wealth is a concern. The paper claims that even though redesigning industrial policy such that it becomes more conditioned on export outcomes is not a solution to the problem, it is, however, one of its important ingredients.
Biological study of sweet fennel fruits on regeneration of liver cells دراسة بيولوجية لثمار الشمر الحمو لتجديد خلايا الکبد

Only one strain of common fennel (Foeniculum vulgare Mill.) was cultivated in Egypt for the national and international purpose. The cultivar yields big fruits and reasonable percentage of essential oil with particularly high estragole content, but it is poor in fenchone which is an important constituent of the fennel essential oil. Sixity albino male rats (Sprague Dowely strain) of an average weight 120 ± 10 g were divided into 20 groups each group contains 5 rats. Group1:Control group (control negative) 5 rats were fed on basal diet for 30 days. Group 2 : Control group( 5 Rats which were induced by CCl4) (control positive )5 rats were fed on basal diet for 30 days. Group3: 5 rats were fed on basal diet containing sweet fennel 5%, 10% and 15%. Group4: 5 rats were fed on basal diet containing Bitter fennel 5% ,10% and 15%. The results revealed that hepatoprotective effect of sweet fennel was very obvious ,where the rats treated with CCl4 but received S.F ( T4 ) indicated lower value of ALT & AST which significantly differed with T2 and T4 of treated rats with CCl4 of S.F the result revealed that fennel had better effect at 5%where Concerning the effect of fennel concentration , the result revealed that fennel had better effect at 5%where ALT & AST value was over all fennel varieties, while increasing level of fennel led to increase ALT & AST.
2021 Analyzing Error Analysis in Google Translate: A Case Study of a Medical Text

Both sparing time and efforts urged a necessity to use machine translation (MT) systems such as Google Translate to translate texts all over the world. During the last decades, GT was the focus of attention for being the most used MT system for its speed and almost accurate product. This study emerged from the fact that English and Arabic translation via MT has many errors that need to be highlighted since both languages belong to different linguistic systems. In order to evaluate the quality of GT system, this study used error analysis with a view to identifying different error types in GT. The error analysis focused on studying the mismatching syntactic, morphological, lexical and semantic components in the source text and the target text. The case study for this research is an English medical text that is chosen to evaluate the accuracy and usefulness of GT in translating the English medical terms and statements. The results revealed that the most frequently occurring errors were semantic errors (30%) and syntactic errors (30%), morphological errors ranked second (25%) while lexical errors ranked last (15%).
Eccentric Overload during Resistance Exercise: A Stimulus for Enhanced Satellite Cell Activation

ABSTRACT Satellite cells (SC) are of importance for muscular adaptation to various forms of exercise. A single bout of high-force eccentric exercise has been shown to induce SC activation and, for electrically stimulated exercise, SC differentiation. Purpose This study aimed to assess if one bout of concentric/eccentric exercise with damaging eccentric overload (CON/ECC+) provides a sufficient stimulus to induce SC activation, proliferation, and differentiation. Methods Biopsies from the vastus lateralis muscle of recreationally active men were obtained in the rested condition and again from the contralateral leg 7 d after exhaustive concentric/eccentric (CON/ECC) (n = 15) or CON/ECC+ (n = 15) leg extension exercise and in a nonexercising control group (CG) (n = 10). Total SC number (Pax7+), activated (Pax7+/MyoD+), and differentiating (myogenin+) SCs, fiber type distribution, and myofibers expressing neonatal myosin heavy chain (MHCneo) were determined immunohistochemically. Creatine kinase and myoglobin were measured in venous blood. Isokinetic strength tests were repeatedly conducted. Results Significant increases in creatine kinase and myoglobin (P = 0.001) indicated myofiber damage, whereas maximal strength was not impaired. Only after CON/ECC+, SC content (P = 0.019) and SC related to type II fibers (P = 0.011) were significantly increased. A significant increase in the proportion of activated SCs occurred after CON/ECC+ only (P = 0.003), the increase being significantly (P < 0.05) different from the changes after CON/ECC and in CG. The number of differentiating SC and MHCneo remained unchanged. Conclusions Eccentric overload during leg extension exercise induced significant SC activation, increases in SC content and in SC number related to type II myofibers. However, there were no signs of increased SC differentiation or formation of new myofibers.
Overexpression of HIF1α in Hunner Lesions of Interstitial Cystitis: Pathophysiological Implications

Purpose: The aim of our study was to elucidate biological changes in Hunner lesions, which underlie the pathophysiology of Hunner-type interstitial cystitis, by characterizing their whole transcriptome and immunopathological profiles. Materials and Methods: Paired bladder mucosal biopsies, 1 sample each from the Hunner lesion and nonlesion area, were obtained from 25 patients with Hunner-type interstitial cystitis. The samples were subjected to whole-transcriptome profiling; immunohistochemical quantification of CD3, CD4, CD8, CD20, CD138, mast cell tryptase, cytokeratin and HIF1α; and quantitative polymerase chain reaction for IFN-α, IFN-β, IFN-γ, TNF, TGF-β1, HIF1α, IL-2, IL-4, IL-6, IL-10 and IL-12A. The results were compared between the lesion and nonlesion areas. Results: RNA sequencing identified 109 differentially expressed genes and 30 significantly enriched biological pathways in Hunner lesions. Up-regulated pathways (24) included HIF1α signaling pathway, PI3K-Akt signaling pathway, RAS signaling pathway and MAPK signaling pathway. By contrast, down-regulated pathways (6) included basal cell carcinoma and protein digestion and absorption. The mRNA levels of HIF1α, IFN-γ and IL-2, and the HIF1α protein level were significantly higher in lesion areas. Otherwise, there were no significant differences between the lesion and nonlesion samples in terms of mRNA levels of inflammatory cytokines or histological features such as lymphoplasmacytic and mast cell infiltration, epithelial denudation and CD4/CD8 T-lymphocyte ratio. Conclusions: Our findings demonstrate significant overexpression of HIF1α and up-regulation of its related biological pathways in Hunner lesions. The results indicate that ischemia, in conjunction with inflammation, plays a pathophysiological role in this subtype of interstitial cystitis/bladder pain syndrome, particularly in Hunner lesions.
Comparative digestibility and rumen fermentation of camels and sheep fed different forage sources

Abstract The present study evaluated the effects of forage sources on dry matter (DM) intake, digestibility, and fermentation parameters in camels vs. sheep. The study was arranged as a 2 × 3 factorial experiment in a completely randomized design by using two animal species (three ruminally cannulated female camels and three male sheep) and three forage sources. The forages were (1) alfalfa hay; 164 and 479 g/kg DM for crude protein (CP) and neutral detergent fiber (NDF), respectively, (2) berseem hay; 121 and 513 g/kg DM for CP and NDF, respectively, and (3) wheat straw (27.5 and 723 g/kg DM for CP and NDF, respectively). Higher DM intake [g/kg body weight (BW)] was noted in sheep compared to camel when alfalfa hay (p < 0.05) and berseem hay (p < 0.05) were fed but was similar between both species when they were fed wheat straw. Forage type rather than animal species had more effect on metabolic intake. Lower digestibility was noted in sheep with wheat straw (p < 0.05). Similar in situ degradability values for crude protein and DM were noted between camels and sheep. In situ degradability of NDF was higher (p < 0.05) in camel than sheep. Greater ruminal pH (p < 0.05) was noted in sheep vs. camels when berseem hay and wheat straw were fed. Lower ruminal passage rate (p < 0.05) was noted in camels and higher total mean retention time. It was concluded that sheep and camels had similar digestion capacities when fed berseem hay and alfalfa hay, however, camels are more efficient than sheep when fed wheat straw.
Novel LAMC2 fusion protein has tumor‐promoting properties in ovarian carcinoma

Laminins are heterotrimeric ECM proteins composed of α, β, and γ chains. The γ2 chain (Lm‐γ2) is a frequently expressed monomer and its expression is closely associated with cancer progression. Laminin‐γ2 contains an epidermal growth factor (EGF)‐like domain in its domain III (DIII or LEb). Matrix metalloproteinases can cleave off the DIII region of Lm‐γ2 that retains the ligand activity for EGF receptor (EGFR). Herein, we show that a novel short form of Lm‐γ2 (Lm‐γ2F) containing DIII is generated without requiring MMPs and chromosomal translocation between LAMC2 on chromosome 1 and NR6A1 gene locus on chromosome 9 in human ovarian cancer SKOV3 cells. Laminin‐γ2F is expressed as a truncated form lacking domains I and II, which are essential for its association with Lm‐α3 and ‐β3 chains of Lm‐332. Secreted Lm‐γ2F can act as an EGFR ligand activating the EGFR/AKT pathways more effectively than does the Lm‐γ2 chain, which in turn promotes proliferation, survival, and motility of ovarian cancer cells. LAMC2‐NR6A1 translocation was detected using in situ hybridization, and fusion transcripts were expressed in ovarian cancer cell tissues. Overexpression and suppression of fusion transcripts significantly increased and decreased the tumorigenic growth of cells in mouse models, respectively.
Subcutaneous irrigation with rifampicin vs. povidone-iodine for the prevention of incisional surgical site infections following caesarean section: a prospective, randomised, controlled trial

Abstract The aim is to investigate the effect of irrigation of subcutaneous tissue with saline, rifampicin, or povidone-iodine on incisional surgical site infections following caesarean section. Three hundred patients scheduled for caesarean section were randomly assigned into one of three groups of 100 members each, as follows: the subcutaneous tissue was irrigated with saline in group 1 (control); saline + rifampicin in group 2; saline + 10% povidone-iodine in group 3. Patients who developed a superficial incisional surgical site infection within 30 days were recorded. The surgical site infection rate did not differ when using rifampicin or povidone-iodine (p = .202). It was observed that there was a statistically significant increase in the rate of incisional surgical site infections as the existence of comorbidities (p = .001), perioperative blood transfusion (p = .020), and midline incision (p = .004). Irrigation of subcutaneous tissue with rifampicin or 10% povidone-iodine is not effective in preventing surgical site infections after caesarean section. IMPACT STATEMENT What is already known on this subject? An increase has recently been observed in the incidence of SSI particularly in caesarean sections due to reasons, such as that elderly mothers are more commonly operated on compared to the past and long and complicated operations (Lachiewicz et al. 2015) and there are no clear decisions on measures to be taken. Also, there are not many studies on this subject (De Nardo et al. 2016; Solomkin et al. 2017). What do the results of this study add? In our study, we investigated the effectiveness of subcutaneous agents that have been used by many surgeons for years and we've revealed that it's not effective. There is no study in the literature comparing 3 different irrigation agents as we did in our study. For this reason, we think that we will make an important contribution to the measures to be taken in this important issue. What are the implications of these findings for clinical practice and/or further research? This study may contribute to reaching a sufficient level of evidence on surgical wound infections after caesarean sections, which are still missing in the literature, and that may be guiding for the studies that will be conducted on this subject in the future.
A meta-analytic review of adaptive functioning in fetal alcohol spectrum disorders, and the effect of IQ, executive functioning, and age.

INTRODUCTION Fetal alcohol spectrum disorders (FASD) are highly prevalent developmental disabilities associated with prenatal alcohol exposure. In addition to varied strengths and unique talents, people with FASD experience significant challenges, including in adaptive functioning. Adaptive functioning refers to skills related to everyday life such as communication, practical skills, and social skills. For the current review we aimed to understand how adaptive functioning in FASD compares to that of nonexposed individuals and those with attention deficit-hyperactivity disorder (ADHD). Additionally, we investigated how this relationship may change based on IQ, executive functioning, and age. METHOD The current review was registered in the International Prospective Register of Systematic Reviews (PROSPERO). Studies were eligible for inclusion if they measured adaptive functioning and included an FASD group and at least one eligible comparison group. Articles available in May 2021 in PubMed, PsycInfo, Scopus, and ProQuest Dissertations were searched. Publication bias was assessed using Egger's regression and three-level random effects models were computed for all domains of adaptive functioning. Possible moderation of IQ, executive functioning, and age were investigated if heterogeneity analyses were significant. A post-hoc moderation analysis of recruitment method was also completed. RESULTS Thirty studies were included. Individuals with FASD had significantly lower adaptive functioning relative to other groups, with effect sizes ranging from 1.04-1.35 compared to nonexposed groups and . 30-. 43 compared to ADHD groups. No significant moderating effects were found for IQ, or age; executive functioning significantly moderated communication skills in FASD compared to the nonexposed group. Recruitment method significantly affected this relationship, with larger effect sizes on average found for clinically-identified samples compared to at-risk or population samples. CONCLUSIONS Individuals with FASD have impairments in adaptive functioning relative to nonexposed and ADHD groups, regardless of IQ, executive functioning, or age. Limitations include low sample sizes in some comparisons and limited age range.
Bclaf1 regulates c‐FLIP expression and protects cells from TNF‐induced apoptosis and tissue injury

TNF stimulation generates pro‐survival signals through activation of NF‐κB that restrict the build‐in death signaling triggered by TNF. The competition between TNF‐induced survival and death signals ultimately determines the fate of a cell. Here, we report the identification of Bclaf1 as a novel component of the anti‐apoptotic program of TNF. Bclaf1 depletion in multiple cells sensitizes cells to TNF‐induced apoptosis but not to necroptosis. Bclaf1 exerts its anti‐apoptotic function by promoting the transcription of CFLAR, a caspase 8 antagonist, downstream of NF‐κB activation. Bclaf1 binds to the p50 subunit of NF‐κB, which is required for Bclaf1 to stimulate CFLAR transcription. Finally, in Bclaf1 siRNA administered mice, TNF‐induced small intestine injury is much more severe than in control mice with aggravated signs of apoptosis and pyroptosis. These results suggest Bclaf1 is a key regulator in TNF‐induced apoptosis, both in vitro and in vivo.
Oscillospira - a candidate for the next-generation probiotics

ABSTRACT Oscillospira is a class of organism that often appears in high-throughput sequencing data but has not been purely cultured and is widely present in the animal and human intestines. There is a strong association between variation in Oscillospira abundance and obesity, leanness, and human health. In addition, a growing body of studies has shown that Oscillospira is also implicated in other diseases, such as gallstones and chronic constipation, and has shown some correlation with the positive or negative changes in its course. Sequencing data combined with metabolic profiling indicate that Oscillospira is likely to be a genus capable of producing short-chain fatty acids (SCFAs) such as butyrate, which is an important reference indicator for screening “next-generation probiotics “. Considering the positive effects of Oscillospira in some specific diseases, such as obesity-related metabolic diseases, it has already been characterized as one of the next-generation probiotic candidates and therefore has great potential for development and application in the future food, health care, and biopharmaceutical products.
Mindfulness and Sexual Dysfunction: A Systematic Research Synthesis

Abstract Throughout the previous decade, research exploring the associations between mindfulness and sexual dysfunction has grown exponentially. Researchers have highlighted inverse associations between mindfulness and various sexual dysfunctions, including erectile dysfunction, hypersexuality, and sexual distress, as well as positive associations between mindfulness and sexual desire, sexual satisfaction, and overall sexual functioning. This study sought to describe the state of extant literature exploring the association between mindfulness and sexual dysfunction, identify areas for future study within this area of research, and inform clinical practice when working with those experiencing sexual dysfunction. A systematic search of peer-reviewed journal articles revealed a final sample of 18 articles. After collecting data from all included articles, results support the inverse association between mindfulness and various sexual dysfunctions. Additionally, results highlight that current mindfulness and sexual dysfunction literature focuses more on the individual’s experience and does not fully consider how the couple system is often impacted by, and may contribute to, the maintenance of sexual dysfunction. Furthermore, results demonstrate the importance of including LGBTQ + populations in future research, as extant literature in this area has focused primarily on the heterosexual experience.
Sexual Assault as a Contributor to Academic Outcomes in University: A Systematic Review

Sexual assault continues to be a prevalent and consequential experience for university students. The aim of this systematic review was to synthesize the literature on the academic consequences of the sexual assault for university students. There is currently no comprehensive review of the literature focusing on the academic consequences for university students who experienced sexual assault. This review was conducted based on searches from five databases including Academic Search Complete, Education Search Complete, Education Resources Information Center (ERIC), PsycINFO, and Google Scholar. We identified 13 articles that examined academic consequences of sexual assault during university. Across all studies, sexual assault was associated with more academic problems including lower grade point average, dropping out of university, and self-regulated learning problems. Although the number of articles is small, the results are consistent. Practically, this means that universities, those providing psychological services, and victims themselves need to understand that the consequences are not just physical and psychological but can also negatively impact academic achievement. Our review also identifies limitations in the literature regarding this topic such as methodological concerns, diversity and inclusion concerns, and the need for future work to investigate mediators of the relationship between sexual assault and academic outcomes. We offer recommendations for future research to combat the concerns identified. Development of interventions to support those who experience sexual assault during university necessitates overcoming the limitations identified.
The effect of head movement restriction on the kinematics of the spine during lifting and lowering tasks

Abstract This study aimed to examine the effects of head movement restriction on relative angles and their derivatives using the stepwise segmentation approach during lifting and lowering tasks. Ten healthy men lifted and lowered a box using two styles (stoop and squat), with two loads (i.e. 10% and 20% of body weight); they performed these tasks with two instructed head postures [(1) Flexing the neck to keep contact between chin and chest over the task cycle; (2) No instruction, free head posture]. The neck flexion significantly affected the flexion angle of all segments of the spine and specifically the lumbar part. Additionally, this posture significantly affected the derivatives of the relative angles and manifested latency in spine segments movement, that is, cephalad-to-caudad or caudad-to-cephalad patterns. Conclusively, neck flexion as an awkward posture could increase the risk of low back pain during lifting and lowering tasks in occupational environments. Practitioner summary: Little information is available about the effects of neck flexion on other spine segments’ kinematics and movement patterns, specifically about the lumbar spine. The result of this experimental study shows that neck flexion can increase the risk of low back pain by increasing lumbar flexion angle and spine awkward posture.
Unexplored Cdc42 functions at the budding yeast nucleus suggested by subcellular localization

ABSTRACT In budding yeast, the Rho-family GTPase Cdc42 has several functions that depend on its subcellular localization and the cell cycle stage. During bud formation, Cdc42 localizes to the plasma membrane at the bud tip and bud neck where it carries out functions in actin polymerization, spindle positioning, and exocytosis to ensure proper polarity development. Recent live-cell imaging analysis revealed a novel localization of Cdc42 to a discrete intracellular focus associated with the vacuole and nuclear envelope. The discovery of this novel Cdc42 localization led to the identification of a new function in ESCRT-mediated nuclear envelope sealing. However, other aspects of this intracellular localization and its functional implications were not explored. Here, we further characterize the Cdc42 focus and present several novel observations that suggest possible additional Cdc42 functions at the nucleus, including nucleus-vacuole junction formation, nuclear envelope tethering, nuclear migration, and nucleopodia formation.