Miracle-dz/UniFAR-FTUs huggingface dataset:
Turbine-level clustering for improved short-term wind power forecasting

At the present time, new types of data are collected at a turbine level, and can be used to enhance the skill of short-term wind power forecasts. In particular, high resolution measurements such as wind power and wind speed are gathered using SCADA systems. These data can be used to build turbine-tailored forecasting models, but at a higher computational cost to predict the production of the overall wind farm compared to a single farm-level model. Thus, we explore the potential of the DBSCAN clustering algorithm to group wind turbines and build forecasting models at a cluster-level to find a middle ground between forecasting accuracy and computational cost. The proposed approach is evaluated using SCADA data collected in two Irish wind farms.
Multi-fidelity Analyses of Rotor Loads of Floating Offshore Wind Turbines with Wind/Wave Misalignment

Reliable predictions of the aero- and hydrodynamic loads of fixed-bottom and floating offshore wind turbines are paramount for assessing fatigue life and designing load and power control systems. However, significant uncertainty affecting aerodynamic predictions still exists. This study presents cross-comparative analyses of the predictions of aerodynamic loads and power of fixed-foundation and floating wind turbine rotors with and without yaw errors using time- and frequency-domain Navier-Stokes Computational Fluid Dynamics, and the Blade Element Momentum theory. The considered test case is the National Renewable Energy Laboratory 5 MW reference turbine, assumed to be mounted in the floating case on a semi-submersible platform and undergoing pitching motion about the tower base. Although the overall qualitative agreement of the low- and high-fidelity predictions is found to be fair in all cases, for the considered regimes the agreement between the two methods is better for the pitching rotor in aligned wind than for the yawed flows regardless of the tower motion.
Performance Studies and Correlation between Vehicle- and Rapid- Aged Commercial Lean NOx Trap Catalysts

Even though substantial improvements have been made for the lean NOx trap (LNT) catalyst in recent years, the durability still remains problematic because of the sulfur poisoning and sintering of the precious metals at high operating temperatures. Hence, commercial LNT catalysts were aged and tested in order to investigate their performance and activity degradation compared to the fresh catalyst, and establish a proper correlation between the aging methods used. The target of this study is to provide useful information for regeneration strategies and optimize the catalyst management for better performance and durability. With this goal in mind, two different aging procedures were implemented in this investigation. A catalyst was vehicle-aged in the vehicle chassis dynamometer for 100000 km, thus exposed to real conditions. Whereas, an accelerated aging method was used by subjecting a fresh LNT catalyst at 800 °C for 24 hours in an oven under controlled conditions. Engine dynamometer studies were performed with a Volvo mid-sized diesel engine with the purpose of testing the NOx storage and reduction performance, as well as the THC and CO conversion activity of the catalysts under controlled conditions. The aged catalysts activity was shown to be significantly degraded, mainly at low working temperatures compared to the fresh LNT, and one reason for this could be limited NO oxidation. In addition, the oven-aged sample was found to be well correlated to the vehicle-aged catalyst. On top of that, several vehicle emission cycles were carried out in the vehicle chassis dynamometer with a 2.0 l Volvo XC90 diesel vehicle in order to study the catalysts performance under real driving conditions and monitor the gradual deterioration of the vehicle-aged catalyst during the vehicle aging testing.
An Empirical Analysis on Business Intelligence Maturity in Malaysian Organizations

One of the greatest challenges organizations face today is the lack of infrastructure management. With the increased complexity and information overload, it is difficult for organizations to make quick and informed decisions at the pace required by today’s rapidly changing market. Business intelligence (BI) represents a significant opportunity to improve decision making by providing right information in a timely manner at the right place for the right people. Doing this requires the right management of infrastructure (e.g., people, processes, functionalities) to ensure that the BI environment meets the business expectations and lift BI capabilities to higher level. This researchin-progress paper focuses on an empirical analysis of a proposed BI maturity model among Malaysian organizations. This maturity model comprises of four dimensions: organizational, process, technology, and outcome, spanning across five levels of maturity. An empirical study was undertaken with the development of a structured questionnaire to examine the efficiency of each dimension of BI maturity. Study results show that outcome and organizational dimensions have a higher impact on the BI maturity level of Malaysian organizations. Results also indicate that none of the organizations in Malaysia have achieved level 5 and most of them are still at low level of maturity across all the four dimensions that built into the BI maturity model. Through the understanding of dimensions that affect current level of BI maturity, effective BI roadmaps can be formulated to assist the organizations to make necessary improvement in BI capabilities and keep them productively engaged for a long-term in achieving sustained high performance.
CRKL Links p210 with Paxillin in Chronic Myelogenous Leukemia Cells*

From the ‡Division of Hematologic Malignancies and iCellular and Molecular Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, the §Section of Molecular Carcinogenesis, Department of Pathology, Childrens Hospital, Los Angeles, California 90027, and the ¶Division of Hematology and Medical Oncology, Oregon Health Sciences University, Portland, Oregon 97201-3098
Total Quality Management in Central America: A case study in leadership and data-based dialogue

This dissertation compares the approaches taken by two general managers of similar production operations in the implementation of total quality management programs in two Central American settings. Policy deployment enabled one general manager to resist strong cultural pressure to assume direct control of the quality council, as one would have expected in a high power distance setting. He implemented the innovation at lower levels of the organization even though the quality council was not ready to assume leadership of the process. The other general manager s approach was less effective because he behaved opportunistically and focused on alignment of the quality council with his perception of total quality management before diffusing the innovation throughout the organization. A contingency that was present in both settings before the innovation adoption process began was collaborative problem-solving (i.e., data-based dialogue) between foremen and production unit managers. The policy deployment strategy of the first general manager enabled his programs to reach and be reinforced by the users of this mode of interaction, while the strategy of the second manager did not allow this to happen. The research process consisted of 26 months of participant observation, attitude surveys contrasting the attitudes of total quality management program participants (n = 80) and non-participants (n = 82), and interviews within production units (n = 17). The total quality management participants had significantly more positive attitudes, as measured by the Sabiers-Pasmore socio-technical systems benchmark survey (1992), than the non-participants in the production operation where policy deployment occurred. This was not the case in the other location where the manager coopted the quality council in his effort to align it with his perception of total quality management. The implications of the preceding are the following: (1) in high power distance settings, managers must be deliberate in their policy deployment to counter the strong cultural pull of autocratic control; and (2) total quality management may depend on existing contingencies such as data-based dialogue. The main contribution of the research is the assessment of contingencies to consider in implementing total quality management in Central America.
Dexmedetomidine versus Midazolam as an Anesthetic Adjuvant in Pediatric Cardiac Surgery: An Entropy Evaluation Study

Volatile anesthetics have dose-dependent myocardial depressant properties. Thus anesthetists should balance between myocardial stability and adequate depth of anesthesia. Certain adjuvant drugs like dexmedetomedine and midazolam can be used to obtain adequate depth of anesthesia with lower inhalational anesthetic requirement. Thus, avoiding of inhalational anesthetic drugs associated myocardial suppressing affect in such patients with already diseased heart. open heart surgery were divided into two groups. One received dexmedetomedine (0.5 μg/Kg/hour) and the other received midazolam infusion (0.05 mg/Kg/hour) as adjuvant to sevoflurane based anesthesia monitored by entropy. End-tidal concentration of sevoflurane, heart rate, MAP, additional fentanyl boluses, extubation time, vomiting and emergence agitation were all recorded. Sevoflurane end tidal concentration, entropy readings, additional doses of fentanyl, heart rate, MAP, were higher in midazolam group when compared to dexmedetomedine group. Similarly extubation time was longer in midazolam group in comparison to dexmetetomedine group. Emergence agitation score was of no significant value between dexmedetomedine and midazolam group. with continuous infusion of 0.5 μg/Kg/hour dexmedetomedine during sevoflurane based anesthesia, lower end tidal sevoflurane concentration and entropy readings were noticed in comparison to midazolam infusion. In addition, lowers intraoperative additional opioid requirements and shorter extubation time with more hypotension and bradycardia were observed with dexmedetomedine infusion when compared to midazolam infusion in pediatric congenital corrective cardiac surgery.
Biological and Clinical Effects of Intravenous Tumor Necrosis Factor-Â« Administered Three Times Weekly1

Tumor necrosis factor (TNK) is a cytokine Â«Â¡Ih pleiotropic biological and antitumor effects iti ritro and in mouse models. The immunological effects of the molecule as a single agent, however, have not been well studied clinically. \Ve conducted a Phase I trial of TNF in 53 patients with advanced malignancies in order to determine the biological and clinical effects of TNK when administered as a 30-min i.v. infusion three times/week. Dose levels of TNK ranged from 5 to 275 Mg/nr; doses of TNK were escalated between patient groups. The most common clinical toxicities of TNK consisted of rigors, anorexia, headache, and fatigue. Dose-limiting toxicity consisted of hypotension, fatigue, and nausea. 1our patients treated at the maximally tolerated dose of 225 //g 'm ' received dexamethasone to determine whether the toxicities of TNK could be ameliorated. No significant differences in hypotension or subjective symp tomatology were observed in those patients receiving dexamethasone and those who did not or between injections in which dexamethasone was administered and when it Â»asnot. One patient with colorectal carcinoma treated with 50 Mg/m~had a partial response lasting about 9 months. Biological responses were evaluated in 8 patients treated at the maxi mally tolerated dose before therapy and 24 h afterward. INK significantly (/' < 0.05 for all) enhanced serum ^'-microglobulin, serum neopterin, and serum interleukin-2 receptor (Tac antigen) levels. Indoleamine 2,3dioxygenasc activity was also increased 24 h following the administration of TNK, although this increase was only of borderline statistical signifi cance (P = 0.07). TNF did not enhance granulocyte bactericidal activity. The expression of cell surface proteins on monocytes, including HLADR. IH.A-DQ, Â¿P-microglobulin,and the Kc receptor, and serum interleukin-l activity also were not significantly increased by the administra tion of TNF. thus, in humans TNF caused biological response modulation with evidence of 11LA Class I (.; -niicroglohii lin) increase and T-cell (Tac antigen) and monocyte (neopterin) activation.
Handling states in redundant and additional protocol testing

This paper addresses the problem of conformance testing of protocols modeled by FSMs with redundant states. Redundant states appear in an FSM which may be nonminimal or nonconnected. The existing test derivation methods usually are not directly applicable to these machines. In this paper, we show that they can be adjusted to cover this class of FSMs and that the traditional assumption on the minimality of machines is not necessary. Another problem with redundant states is that they can cause the appearance of additional states in protocol implementations whose guaranteed detection requires tests of an exponential length. This paper proposes techniques for deriving tests for FSMs with redundant or additional states such that a high fault coverage is achieved while maintaining an acceptable test suite length. The effectiveness of the proposed methods has been evaluated in an experimental way using a benchmark protocol.
p27 Repression of ErbB2-Induced Mammary Tumor Growth in Transgenic Mice Involves Skp2 and Wnt/B-Catenin Signaling

Expression of the cyclin-dependent kinase (Cdk) inhibitor (p27) is frequently reduced in human tumors, often correlating with poor prognosis. p27 functions as a haploinsufficient tumor suppressor; however, the mechanism by which one allele of p27 regulates oncogenic signaling in vivo is not well understood. We therefore investigated the mechanisms by which p27 inhibits mammary tumor onset. Using the common background strain of FVB, p27 heterozygosity (p27 ) accelerated ErbB2-induced mammary tumorigenesis. We conducted microarray analyses of mammary tumors developing in mice with genetic haploinsufficiency for p27 expressing a mammary-targeted ErbB2 oncogene. Global gene expression profiling and Western blot analysis of ErbB2/p27 tumors showed that the loss of p27 induced genes promoting lymphangiogenesis, cellular proliferation, and collaborative oncogenic signaling (Wnt/b-catenin/Tcf, Cdc25a, Smad7, and Skp2). Skp2 expression was induced by ErbB2 and repressed by p27. Degradation of p27 involves an SCF-type E3 ubiquitin ligase, including Skp2. The Skp2 component of the SCF complex that degrades p27 was increased in ErbB2 tumors correlatingwith earlier tumor onset. In bothmurine and human ErbB2-overexpressing breast cancers, p27 levels correlated inversely with Skp2. p27 haploinsufficiency activated Wnt/B-catenin/hedgehog signaling. Reintroduction of p27 inhibited B-catenin induction of Tcf-responsive genes (Siamosis, c-Myc, and Smad7). p27 is haploinsufficient for ErbB2 mammary tumor suppression in vivo and functions to repress collaborative oncogenic signals including Skp2 and Wnt/B-catenin signaling. (Cancer Res 2006; 66(17): 8529-41)
GRANULOCYTE COLONY STIMULATING FACTOR (G-CSF) QUANTITATIVE ANALYSIS IN PLASMODIUM VIVAX INFECTED MALARIA PATIENTS EXPERIENCING TROMBOCYTOPENIA

Abstract Introduction : P. Vivax has been refered as pathological factor underlying increasing prevalences of haematological abnormality including anemia and thrombocytopenia. Through the day, exact mechanism of thrombocytopenia in malaria infection has yet come to a conclusion, several hypothesis are still in considered, phagocytosis and platelets aggregation remain the major disscussion topics. G-CSF, cytocine with elevated serum quantity in P. Vivax infections, were responsible in increasing phagoctytosis and conducting direct effect on platelets aggregation using adequate ADP. Increasing number of ADP in malaria cases were correlated with erythrocyte haemolitic, leading to increasing platelets aggregation. Although numerous hypothesis has been compelled, only a-few research publication has been made corresponding to G-CSF serum level on malaria P. Vivax infection and its correlations to thrombocytopenic events. Aim of study : To analyze the relations between G-CSF serum levels and parasite numbers towards platelets profile in infected malaria P. Vivax patients. Methods : Study design using Prospective analysis. Thirty six patients with single infection of Malaria Vivax in Puskesmas Sukamaju (Primary Heath Care Centre) and Puskesmas Kota Karang were assessed for G-CSF plasma levels, platelet counts, and MPV. Data analysis were conducted using Spearman correlation methods with SPSS. Results : Study results showing significant correlation between G-CSF serum levels towards Platelet conts (R = -0,397(p = 0,016)), without significant correlation between G-CSF and MPV value (p = 0,874) Conclusion : G-CSF serum levels were related with thrombocytopenia, with no correlation towards MPV. Keyword: G-CSF, P. vivax, Thrombocytopenia, MPV.
TRANSFORMATION OF TOOLS AND CONSERVATION OF ARCHITECTURE SOME RESEARCHES ON THE USE OF DIGITAL SYSTEMS FOR THE INTERVENTION ON THE HISTORICAL BUILDINGS

The use of digital technologies to study architecture and landscape has begun to represent an innova- tive aspect of the research when it started to allow the dynamic association (as input and output) of images and alphanumeric data: the different combination of this information through inferences and algorithms and the consequent generation of new data has freed digitisation from a strictly instrumental role making it a new methodological approach in itself. As a matter of fact, recently architectural research has begun to take an interest in the problem ‘from within’, working not only on the application of computer tools but, more consciously, on their configu -ration. The work carried out by the Sapienza research group is aimed at developing ontologies and inferential models specifically dedicated to the representation of historical buildings and is devoted to the implementation of a national GIS platform for the historical centres, the Risk Map of the Italian Ministry of Cultural Heritage and Activities and Tourism. This kind of work involves a series of methodological issues specially oriented to the definition of the role of the history of architecture in itself and its use for the conservation project. These arguments are developed within this essay, mainly focused on: type and quality of information deriving by the new procedures; interpretative components that fuel the new research methods; cost/benefit ratio in the use of ‘analogue’ and ‘digital’ approaches; future prospects of the two different (traditional and digital) inves-tigative strategies. Moreover, both of the fields of digital research developed by the group (ontology and Risk Map) are here summarised.
Ultra low overhead error mask flip-flop in near threshold voltage processor design

Reducing circuit supply voltage to near-threshold (NT) region is an effective technique for achieving better energy efficiency in current ultra-low power circuit design. However, circuit variation problem becomes extremely worse in NT region and requires more design margin. Error detection and correction (EDAC) designs can remove circuit margin by solving transient error dynamically, but many of the traditional EDAC designs cause large area overhead and cycle per instruction (CPI) penalty. A compact timing error mask flip-flop (EMFF) based on error masking with ultra-low overhead by only adding six transistors (four for error detection and two for error correction) to the conventional flip-flop with 0 CPI penalty is presented. The proposed EMFF reduces system area overhead significantly. Therefore, the timing error tolerance ability is expanded and higher energy efficiency can be archived. EMFF is realised in an industrial processor in SMIC 40 nm CMOS with only 6.8% area overhead, compared with the original processor. At 0.5 V, the EMFF system gains 18.6% performance increasing than the most compact previous work with 3% higher efficiency.
doi:10.1016/j.biocon.2005.03.027 Long-term response of spring X ora to chronic herbivory and deer exclusion in Great Smoky Mountains National Park,

2005 Abstract Chronic herbivory by white-tailed deer ( Odocoileus virginianus Zimmerman) can have profound impacts on the function and structure of forest ecosystems. We examined the combined in X uence of intense herbivory associated with a deer population eruption and chronic herbivory by the post eruption population on the spring X ora of Cades Cove, Great Smoky Mountains National Park. During the 1970s the deer population reached a peak of 43 deer per km 2 , from which it has slowly declined in recent decades. To examine the in X uence of intense herbivory, we compared the abundance and X owering rates of early X owering plants in Cades Cove to a nearby reference site with similar bedrock geology, vegetation, and disturbance history but contrasting history of deer abundance. Our results suggest that signi W cant changes ( p 6 0.05) in the diversity, evenness, and species richness of the spring X ora occurred during the eruptive phase. Trillium spp. and other liliaceous species appeared to be disproportionately impacted. Comparisons between control and exclosure plots established after the deer population eruption indicate that recovery has been largely restricted to species that were able to persist under intense herbivory. These species have increased in number in exclosures, suggest-ing continued impacts by deer on the plant community outside the exclosures. Little to no recolonization by browse sensitive species was observed. Consequently, to restore the natural diversity of early X owering plants once present in Cades Cove, active restoration may be necessary in addition to maintaining deer densities below current
J. Gen. Appl. Microbiol., 59, 21‒31 (2013)

Lipases are ubiquitous enzymes that catalyze the hydrolysis of fats and oils and form a large group of the enzymes. These enzymes also catalyze the hydrolysis of a wide range of carboxyl esters at the water lipid interface and reverse the reaction in the nonaqueous phase. During the last decade, lipases have gained importance, to a certain extent, over proteases and amylases, especially in food industry. Many lipases have been isolated from bacteria, fungi, plants, and animals, and have received much attention as biocatalysts. The enantioselective and regioselective nature of lipases has been used for the resolution of chiral drugs, fat modification, synthesis of cocoa butter substituent, biofuels, and flavor enhancers. Owing to their novel and multifunctional application, lipase-catalyzed processes have received great attention, mainly due to several advantages: (1) they are more environmentfriendly than bulk chemical syntheses, (2) they allow manufacture of higher quality products, (3) they are easy to recover and re-use and (4) they can be used in continuous operations. Although the microbial diversity in nature has been estimated by culture-independent methods, it is uncertain whether it would be possible to find a universal J. Gen. Appl. Microbiol. , 59, 21‒31 (2013)