Miracle-dz/UniFAR-FTUs huggingface dataset:
The Study of Short-Term Plastic Visual Perceptual Training Based on Virtual and Augmented Reality Technology in Amblyopia

Backgrounds The treatment for amblyopia can have a substantial impact on quality of life. Conventional treatments for amblyopia have some limitations, then we try to explore a new and effective method to treat amblyopia. This study aimed to determine the potential effect of short-term plastic visual perceptual training based on VR and AR platforms in amblyopic patients. Methods All observers were blinded to patient groupings. A total of 145 amblyopic children were randomly assigned into 2 groups: VR group (71 patients) and AR group (74 patients). In the VR group, each subject underwent a 20-min short-term plastic visual perceptual training based on a VR platform, and in the AR group, based on an AR platform. The best-corrected visual acuity (BCVA), fine stereopsis, and contrast sensitivity function (CSF) were measured before and after training. Results The BCVA (P < 0.001) and fine stereopsis (P < 0.05) were improved significantly both in VR and AR group after training. Moreover, in the AR group, the CSF showed the value of all spatial frequencies had a statistically signiﬁcant improvement after training (P < 0.05), while in the VR group, only the value of spatial frequency 12 improved significantly (P = 0.008). Conclusions This study showed that the short-term plastic visual perceptual training based on VR and AR technology can improve BCVA, fine stereopsis and CSF of refractive amblyopia. It was suggested that the visual perceptual training based on the VR and AR platforms may be potentially applied in treatment for amblyopia and provided a high-immersing alternative.
Degenerations of Schubert varieties of SL(n)/B to toric varities

Using polytopes defined in an earlier paper, we show in this paper the existence of degenerations of a large class of Schubert varieties of SL_n to toric varieties by extending the method used by Gonciulea and Lakshmibai for a minuscule G/P to Schubert varieties in SL_n
Characteristics of Microstructural Changes Associated with Glioma Related Epilepsy: A Diffusion Tensor Imaging (DTI) Study

(1) Background: Glioma is the most common primary tumor in the central nervous system, and glioma-related epilepsy (GRE) is one of its common symptoms. The abnormalities of white matter fiber tracts are involved in attributing changes in patients with epilepsy (Rudà, R, 2012). This study aimed to assess frontal lobe gliomas’ effects on the cerebral white matter fiber tracts. (2) Methods: Thirty patients with frontal lobe glioma were enrolled and divided into two groups (Ep and nEep). Among them, five patients were excluded due to apparent insular or temporal involvement. A set of 14 age and gender-matched healthy controls were also included. All the enrolled subjects underwent preoperative conventional magnetic resonance images (MRI) and diffusion tensor imaging (DTI). Furthermore, we used tract-based spatial statistics to analyze the characteristics of the white matter fiber tracts. (3) Results: The two patient groups showed similar patterns of mean diffusivity (MD) elevations in most regions; however, in the ipsilateral inferior fronto-occipital fasciculus (IFOF), superior longitudinal fasciculus (SLF), and superior corona radiata, the significant voxels of the EP group were more apparent than in the nEP group. No significant fractional anisotropy (FA) elevations or MD degenerations were found in the current study. (4) Conclusions: Gliomas grow and invade along white matter fiber tracts. This study assessed the effects of GRE on the white matter fiber bundle skeleton by TBSS, and we found that the changes in the white matter skeleton of the frontal lobe tumor-related epilepsy were mainly concentrated in the IFOF, SLF, and superior corona radiata. This reveals that GRE significantly affects the white matter fiber microstructure of the tumor.
Mechanical Fault Diagnosis Technology of Wind Turbine Transmission System Based on Image Features

China’s wind power industry has grown dramatically in recent years as the country’s focus on clean energy and renewable energy generation has increased. Mechanical fault diagnosis of wind power transmission is a common wind maintenance method. It has recently become a research hotspot in the field of mechanical fault diagnosis as a method of fault identification based on picture attributes. Time-frequency images, on the other hand, are better for fault analysis and fault diagnosis of wind power transmission machinery than time-domain and frequency-domain images because they contain more information about the operation status of the gear. This work proposes and applies an image feature extraction-based fault diagnostic method to the defect diagnosis of wind-driven mechanical gears. The feature extraction suitable for gear and gear box faults is analyzed, and the improved artificial immune algorithm is used for fault identification. Through collecting normal vibration signals and two kinds of fault vibration signals from the gearbox of wind power transmission in a wind farm and extracting image features on the basis of data processing, the improved algorithm is finally applied for fault analysis. The experimental results show that the fault diagnosis rate of the improved real-value negative selection algorithm is obviously improved and can improve the fault diagnosis rate by 5%.
Severe Immune-Related Adverse Events: A Case Series of Patients Needing Hospital Admission in a Spanish Oncology Referral Center and Review of the Literature

Immune checkpoint inhibitors (ICI) have revolutionized the landscape of cancer treatment. Although several studies have shown that ICIs have a better safety profile than chemotherapy, some patients develop immune-related adverse events (irAEs), which require specialized and multidisciplinary management. Since ICI indications are rapidly increasing, it is crucial that clinicians involved in cancer care learn to identify irAEs and manage them properly. Here, we report a case series of 23 patients with severe irAEs requiring hospitalization over a period of 12 months and seize the opportunity to review and update different general features related to irAEs along with the management of the most frequent severe irAEs in our series.
N-acetylcysteine in the Treatment of Internet Gaming Disorder

Internet gaming disorder (IGD) is the persistent and recurrent use of the internet to engage in video gaming through a single or multiplayer interface that can lead to significant impairment or distress. With technological advancements in the last decade via portable handheld devices, along with their global availability, video games have found a new medium in which they can provide instantaneous access for casual and enthusiastic users alike. Unfortunately, this exponentially increases the possibility of addiction. IGD shares a similar pathophysiological etiology to addiction as drugs or gambling. However, it can be challenging to manage IGD due to the ease of video game access and limited understanding of the newly recognized disorder. This study aims to fill in the knowledge gap concerning the limited research on internet gaming addiction, its consequential effects on human cognitive-behavioral functioning, and pharmacotherapy management as observed in our patient, who developed IGD, starting initially as a casual recreational hobby among peers. This case also highlights the lack of social awareness and seriousness attributed to this disorder. It focuses on using N-acetylcysteine in the management as well as other psychological and psychotropic drugs.
Les outils d’échafaudage numériques pour l’apprentissage de la résolution de problèmes complexes : analyse des déterminants de l’intention d’utilisation

Les difficultés des apprenants en gestion quant à la résolution de problèmes complexes (RPC) justifient la pertinence de concevoir des outils d’échafaudage numériques (OÉN) pour les assister durant leur processus. Cette étude mixte vise à documenter leurs perceptions à l’égard de ces outils en s’appuyant sur les modèles d’acceptation de la technologie TAM ( Technology Acceptance Model ), TAM2 et TAM3. Les résultats montrent que la perception d’utilité et ses déterminants sont les principaux facteurs qui justifient l’usage. Des analyses factorielles Abstract Management learners’ difficulties in complex problems solving (CPS) justify the relevance of designing digital scaffolds (DS) to assist them during their process. This mixed-methods study aims to document their perceptions of these tools using the TAM (Technology Acceptance Model), TAM2 and TAM3 models. The results show that perceived usefulness and its determinants are the main factors that justify using them. Factor analyses suggest a link between the value given and its perceived usefulness, which could be explained by an expectation-value model. Recommendations for designing useful DS are then proposed.
Prevalence of Ophidiomycosis (Snake Fungal Disease) at a High Disturbance Remediated Landfill and at a Low-Impacted Forest Research Site in East Tennessee, USA

Abstract. Ophidiomycosis (snake fungal disease; SFD) is a disease of conservation concern caused by the fungus Ophidiomyces ophidiicola that threatens the health of snake populations worldwide. Gaps exist in our knowledge about the prevalence of this disease across landscapes. In our study, we compared the prevalence of ophidiomycosis between a low-impacted forest site (n = 93) and a highly disturbed remediated landfill (n = 53) in Anderson County, Tennessee, USA. Free-ranging snakes were examined for the presence of skin lesions that are consistent with ophidiomycosis and were swabbed to detect O. ophidiicola DNA using quantitative PCR (qPCR). Apparent ophidiomycosis (qPCR-positive and skin lesions present) was diagnosed at both sites, but there was no significant difference in prevalence between the two sites (24.7% at the forest site; 22.6% at the landfill site). Apparent ophidiomycosis was most prevalent in Racers (38%; Coluber constrictor) and Ring-Necked Snakes (26%; Diadophis punctatus). There was no difference in ophidiomycosis status between sites for the most-sampled species: Racers, Black Rat Snakes (Pantherophis obsoletus), and Ring-necked Snakes (Diadophis punctatus). Our study represents the first report of ophidiomycosis at focal sites in Tennessee. The findings suggest that O. ophidiicola may be ubiquitous across the landscape and point to the need for further study of diverse habitat types for the prevalence of O. ophidiicola.
Contrast-Enhanced CT Texture Analysis in Colon Cancer: Correlation with Genetic Markers

Abstract Background: The purpose of the study was to determine whether contrast-enhanced CT texture features relate to, and can predict, the presence of specific genetic mutations involved in CRC carcinogenesis. Materials and methods: This retrospective study analyzed the pre-operative CT in the venous phase of patients with CRC, who underwent testing for mutations in the KRAS, NRAS, BRAF, and MSI genes. Using a specific software based on CT images of each patient, for each slice including the tumor a region of interest was manually drawn along the margin, obtaining the volume of interest. A total of 56 texture parameters were extracted that were compared between the wild-type gene group and the mutated gene group. A p-value of <0.05 was considered statistically significant. Results: The study included 47 patients with stage III-IV CRC. Statistically significant differences between the MSS group and the MSI group were found in four parameters: GLRLM RLNU (area under the curve (AUC) 0.72, sensitivity (SE) 77.8%, specificity (SP) 65.8%), GLZLM SZHGE (AUC 0.79, SE 88.9%, SP 65.8%), GLZLM GLNU (AUC 0.74, SE 88.9%, SP 60.5%), and GLZLM ZLNU (AUC 0.77, SE 88.9%, SP 65.8%). Conclusions: The findings support the potential role of the CT texture analysis in detecting MSI in CRC based on pre-treatment CT scans.
Large three-photon absorption in Ba0.5Sr0.5TiO3 films studied using Z-scan technique

Large picosecond nonlinearities in Ba0.5Sr0. 5TiO3 thin films, grown at different temperatures in situ on (100) MgO substrates using rf magnetron sputtering technique, were studied using the Z-scan technique. The nonlinear absorption mechanism, studied near 800 nm using ∼2 and 25 ps pulses, switched from reverse saturable absorption type in the films deposited at temperature 600 °C. The magnitude of the 3PA coefficient was estimated to be ∼10−21 cm3/W2. Two-photon absorption (2PA) was the dominant mechanism recorded with ∼6 ns pulses. The observed behavior is correlated with morphological and crystallographic texture of the films. The linear refractive index and optical band gap of the films have also been calculated and these show a strong dependence on the substrate temperature.
Comparison of Classical and Bayesian Approaches for Intervention Analysis

Intervention analysis has been recently the subject of several studies, mainly because real time series present a wide variety of phenomena that are caused by external and/or unexpected events. In this work, transfer functions are used to model different forms of intervention to the mean level of a time series. This is performed in the framework of state‐space models. Two canonical forms of intervention are considered: pulse and step functions. Static and dynamic explanation of the intervention effects, normal and non‐normal time series, detection of intervention, and study of the effect of outliers are also discussed. The performance of the two approaches is compared in terms of point and interval estimation through Monte Carlo simulation. The methodology was applied to real time series and showed satisfactory results for the intervention models used.
Male-Type Depression Mediates the Relationship between Avoidant Coping and Suicidal Ideation in Men

Despite known links between men’s avoidant coping behaviours (e.g., distraction, denial, substance use) and suicide risk, little research has explored the mechanisms underpinning this relationship. This study sought to examine whether male-type depression symptoms (e.g., anger, aggression, emotion suppression), assessed by the Male Depression Risk Scale, mediate the association between avoidant coping and suicide/self-harm ideation in men. Data were drawn from an online survey of a community sample of 606 Australian men (M age = 50.11 years; SD = 15.00), conducted during the COVID-19 pandemic. Mediation analyses were applied to examine the effect of male-type depression on the association between avoidant coping and suicidal/self-harm ideation, controlling for age, resilience and the experience of two psychosocial stressors during the COVID-19 pandemic (financial stress and government restrictions). Avoidant coping was associated with suicidal/self-harm ideation, r = 0.45, p < 0.001. Results supported a mediating role of male-type depression symptoms in this relationship, R2 = 0.29, PM = 0.36, p < 0.001, underscoring the importance of screening for male-type depression symptoms to better identify men at risk of suicidal/self-harm ideation. Results also suggest a need to support men to develop effective coping strategies, particularly in the context of common psychosocial stressors experienced during the COVID-19 pandemic and beyond.
A HYBRID TWO COMPONENT ACCRETION FLOW SURROUNDING SUPERMASSIVE BLACK HOLES IN AGNs

It is commonly believed that the optical/UV and X-ray emissions in luminous active galactic nuclei (AGNs) are produced in an accretion disk and an embedded hot corona, respectively. The inverse Compton scattering of disk photons by hot electrons in the corona can effectively cool the coronal gas if the mass supply is predominantly via a cool disk-like flow as in black hole X-ray binaries (BHXRBs). Thus, the application of such a model to AGNs fails to produce their observed X-ray emission. As a consequence, a fraction of disk accretion energy is usually assumed to be transferred to the corona. To avoid this assumption, we propose that gas in a vertically extended distribution is supplied to a supermassive black hole by the gravitational capture of interstellar medium or stellar wind material. In this picture, the gas partially condenses to an underlying cool disk as it flows toward the black hole, releasing accretion energy as X-ray emission and supplying mass for the disk accretion. Detailed numerical calculations reveal that the X-ray luminosity can reach a few tens of percent of the bolometric luminosity. The value of &agr; ox ? > varies from 0.9 to 1.2 for the mass supply rate ranging from 0.03 to 0.1 times the Eddington value. The corresponding photon index in the 2–10 keV energy band varies from 1.9 to 2.3. Such a picture provides a natural extension of the model for low luminosity AGNs where condensation is absent at low mass accretion rates and no optically thick disk exists in the inner region.
Algorithms for Cholesky and QR Factorizations, andthe Semidefinite Generalized Eigenvalue Problem

We consider algorithms for three problems in numerical linear algebra: computing the pivoted Cholesky factorization, solving the semidefinite generalized eigenvalue problem and updating the QR factorization. Fortran 77 codes exist in LAPACK for computing the Cholesky factorization (without pivoting) of a symmetric positive definite matrix using Level 2 and 3 BLAS. In LINPACK there is a Level 1 BLAS routine for computing the Cholesky factorization with complete pivoting of a symmetric positive semidefinite matrix. We present two new algorithms and Fortran 77 LAPACK-style codes for computing this pivoted factorization: one using Level 2 BLAS and one using Level 3 BLAS. We show that on modern machines the new codes can be many times faster than the LINPACK code. Also, with a new stopping criterion they provide more reliable rank detection and can have a smaller normwise backward error. The generalized eigenvalue problem Ax=lambda Bx in the case where A and B are real and symmetric and B is positive semidefinite is considered. We present an algorithm for solving this problem that has a potentially smaller operation count than existing methods and requires no further restrictions on A and B. The eigenvalues of the problem are classified as finite or infinite. Nonregular matrix pencils, where the eigenvalues can take any value, are also discussed and a deflation strategy is given. We include a MATLAB code for our algorithm and give some numerical experiments. We also treat the problem of updating the QR factorization, with applications to the least squares problem. Algorithms are presented that compute the factorization A-tilde = Q-tilde R-tilde where A-tilde is the matrix A=QR after it has had a number of rows or columns added or deleted. This is achieved by updating the factors Q and R, and we show this can be much faster than computing the factorization of A-tilde from scratch. We consider algorithms that exploit the Level 3 BLAS where possible and place no restriction on the dimensions of A or the number of rows and columns added or deleted. For some of our algorithms we present Fortran 77 LAPACK-style code and show the backward error of our updated factors is comparable to the error bounds of the QR factorization of A-tilde.
Stress-Tolerant Endophytic Isolate Priestia aryabhattai BPR-9 Modulates Physio-Biochemical Mechanisms in Wheat (Triticum aestivum L.) for Enhanced Salt Tolerance

In efforts to improve plant productivity and enhance defense mechanisms against biotic and abiotic stresses, endophytic bacteria have been used as an alternative to chemical fertilizers and pesticides. In the current study, 25 endophytic microbes recovered from plant organs of Triticum aestivum L. (wheat) were assessed for biotic (phyto-fungal pathogens) and abiotic (salinity, drought, and heavy metal) stress tolerance. Among the recovered isolates, BPR-9 tolerated maximum salinity (18% NaCl), drought (15% PEG-6000), and heavy metals (µg mL−1): Cd (1200), Cr (1000), Cu (1000), Pb (800), and Hg (30). Based on phenotypic and biochemical characteristics, as well as 16S rDNA gene sequencing, endophytic isolate BPR-9 was recognized as Priestia aryabhattai (accession no. OM743254.1). This isolate was revealed as a powerful multi-stress-tolerant crop growth promoter after extensive in-vitro testing for plant growth-promoting attributes, nutrient (phosphate, P; potassium, K; and zinc, Zn) solubilization efficiency, extracellular enzyme (protease, cellulase, amylase, lipase, and pectinase) synthesis, and potential for antagonistic activity against important fungal pathogens viz. Alternaria solani, Rhizoctonia solani, Fusarium oxysporum, and Ustilaginoidea virens. At elevated salt levels, increases were noted in indole-3-acetic acid; siderophores; P, K, and Zn-solubilization; ACC deaminase; and ammonia synthesized by Priestia aryabhattai. Additionally, under in-vitro plant bioassays, wheat seedlings inoculated with P. aryabhattai experienced superior growth compared to non-inoculated seedlings in high salinity (0–15% NaCl) environment. Under NaCl stress, germination rate, plant length, vigor indices, and leaf pigments of wheat seedlings significantly increased following P. aryabhattai inoculation. Furthermore, at 2%-NaCl, B. aryabhattai greatly and significantly (p ≤ 0.05) decreased relative leaf water content, membrane damage, and electrolyte leakage compared with the non-inoculated control. Catalase, superoxide dismutase, and peroxidase activity increased by 29, 32, and 21%, respectively, in wheat seedlings exposed to 2% NaCl and inoculated with the bacteria. The present findings demonstrate that endophytic P. aryabhattai strains might be used in the future as a multi-stress reducer and crop growth promoter in agronomically important crops including cereals.
Aktivitas Antibakteri Ekstrak N-Heksan, Kloroform Dan Etanol Daun Nangka (Artocarpus Heterophyllus Lam.) Terhadap Propionibacterium acnes ATCC 11827

digunakan salah satunya untuk penyakit infeksi. Tujuan penelitian untuk mengetahui aktivitas antibakteri ekstrak n-heksan, kloroform dan etanol daun nangka ( Artocarpus heterophyllus Lam.) Ekstraksi dilakukan dengan cara beringkat dengan metode sokhletasi. Uji aktivitas antibakteri dilakukan dengan menggunakan metode difusi agar. Bakteri uji yang digunakan adalah Propionibacterium acnes ATCC 11827 dengan konsentrasi ekstrak 10.000 µg/mL, 5.000 µg/mL. 2.500 µg/mL 1.250 µg/mL. ABSTRACT: Jackfruit is a plant that is used as herbal medicine, one of which is for infectious diseases. This study aimed to determine the antibacterial activity of the extracts of n-hexane, chloroform and ethanol from jackfruit leaves ( Artocarpus heterophyllus Lam.). The extraction was carried out using soxhletation method. Antibacterial activity test was carried out using the agar diffusion method. The bacteria used was Propionibacterium acnes ATCC 11827 with an extract concentration of 10.000 µg/mL, 5.000 µg/mL. 2.500 µg/mL and 1.250 µg/ mL. The re-sults of antibacterial activity of n-hexane, chloroform and ethanol extracts of jackfruit leaves showed that there was an inhibitory diameter. In the n-hexane, chloroform and ethanol extracts of jackfruit leaves, the largest inhibition diameter was obtained respectively 12,26 mm, 12,36 and 12,26 mm. Phytochemical test with TLC showed that n-hexane extract contained terpenoids and steroids, chloroform extract contained phenols, and ethanol extract contained flavonoids. This shows that the active compounds the extract can inhibit the growth of Propionobacterium acnes ATCC 11827.