Miracle-dz/UniFAR-FTUs huggingface dataset:
Fluid dynamic characterization of a novel branching anastomosis design

Geometric characteristics of a vascular anastomosis can have important biomechanical impacts, particularly in the hemodynamic context of wall shear stress (WSS). In this study, we propose a new branching anastomosis design, the Hybrid anastomosis, to connect a donor vessel to two recipient vessels. The central obstruction characteristic of the traditional Figure 8 anastomosis is mitigated by creating a recessed lumen at the bifurcation. Chicken vessels were used to create and test three Figure 8 and three Hybrid anastomoses ex vivo. Computational fluid dynamics (CFD) simulations of idealized anastomosis designs were then used to verify the experiments and further studied the WSS and WSS gradient (WSSG) profiles of the designs. Experimental results showed increased flow through the Hybrid anastomosis (0.40 ml/s vs. 0.23 ml/s). The mean suture time averaged 20 and 28 min for the Figure 8 and Hybrid anastomoses, respectively. CFD simulations agreed with the experiments; the simulations showed lower flow resistance in the Hybrid anastomosis (1.89 kPa-s/ml vs. 6.77 kPa-s/ml). Most importantly, a set of more physiologically realistic simulations showed that the Hybrid anastomosis reduced WSS and WSSG by over 60% as compared to the Figure 8. Results demonstrated that the proposed Hybrid anastomosis can be created on a comparable surgical time scale (and from the same initial vasculature) as compared to the Figure 8 anastomosis, while decreasing flow resistance and reducing WSS and WSSG considerably. These findings support that the new Hybrid anastomosis may represent a favorable surgical alternative to the Figure 8 design.
Lost property: The European patent system and why it doesn't work

In his blueprint, Bruno van Pottelsberghe first looks at the performance of patent arrangements in Europe, especially their cost effectiveness and the consistency of rules and remedies across countries. He then looks at current attempts at global patent cooperation to see if they will help or hinder the emergence of innovation worldwide and in Europe. Using new and hard-hitting data, van Pottelsberghe paints a dark picture of today's patent landscape both in Europe and internationally. It is a tale of failed public cooperation at all levels and of a regime in danger of rampant patent inflation unless minds and resources are focused on tackling the root causes of the problem. This blueprint comes forward with a sequence of concrete, short-, medium- and long-term policy recommendations to this end.
Intelligent Complex Evolutionary Agent‐Based Systems

In this paper, we investigate the possibility to develop intelligent agent‐based complex systems that use evolutionary learning techniques in order to adapt for the efficient solving of the problems by reorganizing their structure. For this investigation is proposed a complex multiagent system called EAMS (Evolutionary Adaptive Multiagent System), which using an evolutionary learning technique can learn different patterns of reorganization. The realized study proves that evolutionary techniques successfully can be used to create complex multiagent systems capable to intelligently reorganize their structure during their life cycle. The practical establishment of the intelligence of a computational system in generally, an agent‐based system in particularly consists in how efficiently and flexibly the system can solve difficult problems.
P1 - Intelligentes Condition Monitoring von hydraulischen Anlagen

In diesem Beitrag wird eine Zustandsuberwachung fur Hydraulikaggregate vorgestellt, welche aus einer Vielzahl von Sensordatenstromen automatisiert Merkmale extrahiert und diese mittels Korrelationsanalyse auf die Eignung zur Detektion unterschiedlicher Schadenszustande uberpruft. Die jeweils signifikantesten Merkmale werden zum Training einer linearen Diskriminanzanalyse genutzt und anhand der Diskriminanzfunktionen klassifiziert. Das Verfahren wurde auf eine hydraulische Anlage angewendet und erfolgreich validiert. Des Weiteren wurde untersucht, inwieweit der Ausfall einzelner Sensoren von den ubrigen funktionsfahigen Sensoren kompensiert werden kann.
Is the Sky Falling? Energy Security and Transnational Terrorism

Abstract : This paper will assess the extent to which transnational terrorists in particular global Jihadists associated with Osama bin Laden have been interested in attacks against the global energy infrastructure. ] We then assess the extent to which terrorists have in fact targeted that infrastructure and with what effect. We then place these attacks in the context of other supply disruption events. Finally we make suggestions about a viable way ahead. Western fears about the threat posed by transnational terrorists to energy supplies certainly seem warranted. al-Qaeda has repeatedly threatened to disrupt supplies and have followed up on those threats in a few cases. For example following the attack on the French tanker Limburg in October 2002 al-Qaeda issued a statement that it "was not an incidental strike at a passing tanker but.on the international oil-carrying line in the full sense of the word. Moreover al-Qaeda sees the U.S. intervention in Iraq as strongly linked to the supply of oil. A Bin Laden audio tape broadcasted December 19 2004 proclaimed:
Gel formulations for topical drug delivery

(57) Abstract: drug, colloidal silicon dioxide, triacetin and, preferably, pharmaceutical gel formulations for topical drug delivery comprising propylene glycol. Gel formulation, the topical application of the drug skin also 4 mammals to induce cytokines such as interferon and tumor necrosis factor in localization in mucosal, 4-amino-2-ethoxymethyl-. alpha. , alpha-dimethyl the -1H- imidazo [4,5-c] quinolin-1-ethanol is well suited for topical delivery. Gel formulation, there is no need to include irritating components, gel formulations are well suited for topical delivery of drugs for treating diseases involving lesions of the skin and / or mucous membranes.
BEHAVIOUR OF OZONATION BY-PRODUCTS DURING ADVANCED DRINKING WATER TREATMENT WITH PEARL RIVER WATER

Simulation experiments were conducted to investigate the behaviour of ozonation by-products and the removal of organic matter in the treatment of the Pearl River raw water. The treatment processes include pre-ozonation, conventional treatment processes (coagulation/sedimentation and sand filtration), post-ozonation and granular activated carbon (GAC) filtration. Treatment efficiency of each unit process was evaluated by using several parameters such as permanganate index (CODMn), ultraviolet absorbance at 254 nm (UV254), bromate (BrO3-) and formaldehyde. The overall conversion rates of BrO3in the six water samples were 0.43~5.54 %. Treated water flowed through the pre-ozonation unit process in which CODMn and UV254 were greatly removed. The conventional treatment processes had poor ability to remove BrO3-, but were effective in the removal of formaldehyde. In the post-ozonation unit process, the concentrations of BrO3and formaldehyde reached the highest value. GAC filtration enhanced the removal efficiency of BrO3compared with the conventional treatment processes. Water samples from the Xijiang and Beijiang River of the Pearl River basin contained higher concentrations of BrO3and lower values of CODMn, UV254 and formaldehyde in the final effluents than those from the Dongjiang River.
On the Training of Time Sharing Skills: An Attention Viewpoint

Training of time-sharing skills is discussed within an attention framework in which poor time-sharing performance is interpreted to stem from scarcity or inefficient utilization of processing resources. Practice is argued to increase resource availability either by reducing the resource demands of each task, improving coordination, or enhancing the voluntary control on resource allocation. Based on this analysis notions of skill generalizations and implications for the development of training procedures are examined.
The Effects of Secondary Tasks on Naturalistic Driving Performance

Data from 36 drivers involved in a naturalistic driving study were analyzed to determine the frequency and conditions under which drivers engage in secondary behaviors and to explore the relationship these behaviors might have with driving performance. A random selection of 1,440 five-second video clips of the drivers' faces was coded for the occurrence of specific secondary behaviors and the frequency and duration of glances. Corresponding performance data from the instrumented vehicles was used to calculate variability of steering angle, mean and variability of lane position, mean and variability of throttle position, and variability of speed. Contextual factors were also examined, including road type, road curvature, and road condition. Drivers were observed engaged in secondary behaviors in approximately 34% of the clips. Conversation with passengers was the most common secondary behavior (15.3%), followed by grooming (6.5%) and using cellular phones (5.3%). Younger drivers were most likely to engage in secondary behaviors overall (42%). All categories of secondary behavior were associated with significantly higher variability in steering angle. The results for other performance measures were mixed. Cellular phone use, eating/drinking and grooming, resulted in increased steering variance, but did not affect lane position or speed variance. Cellular phone use was associated with the smallest percentage, and shortest mean duration, of glances away from the forward scene, but fewer glances could negatively affect scanning of the roadway environment. However, conversations with passengers showed higher variability in steering angle, increased deviation for both lane position and distance from center of the lane. In general, secondary behaviors are neither equal in frequency of occurrence nor in their effect on driving performance. Drivers appear to perform differently when taking part in different tasks, and appear to engage selectively in secondary behaviors according to traffic/roadway conditions. In naturalistic conditions, when drivers can freely choose whether or not to engage in secondary tasks, drivers may be performing secondary tasks when their driving skills are least needed and the traffic environment tends towards being less challenging based upon a driver's own assessment. These findings highlight the importance of conducting naturalistic studies, as it appears that controlled studies cannot always account for the full effects of driver choice and perceived risk associated with immersion in actual traffic/roadway environments.
Strategies of Visual Search by Novice and Experienced Drivers

Six novice drivers drove a 2.1-mi. neighborhood route and a 4.3-mi. freeway route. Eye movements (including blinks and glances to the vehicle's mirrors and speedometer) were videotaped. The visual behavior of a control group, consisting of four experienced drivers, was also videotaped on the same routes. The results showed that the novice drivers: (1) concentrated their eye fixations in a smaller area as they gained driving experience, (2) looked closer in front of the vehicle and more to the right of the vehicle's direction of travel than the experienced drivers, (3) sampled their mirrors less frequently than the experienced drivers, and (4) made pursuit eye movements on the freeway route while the experienced drivers made only eye fixations. These results suggest that the visual acquisition process of the novice drivers was unskilled and overloaded. Thus, the search and scan patterns of the novice drivers may be considered unsafe in terms of impairing the drivers’ ability to detect circumstances that have high accident potential. On this basis it is recommended that novice drivers be prohibited from driving on public roads until they achieve an acceptable level of vehicle handling control and develop skill in acquiring visual information.
Facebook Said Its Algorithms Do Help Form Echo Chambers, and the Tech Press Missed It

ZEYNEP TUFEKCI is an assistant professor in the School of Information and Library Science at the University of North Carolina, a faculty associate at the Berkman Center for Internet and Society at Harvard University and a former fellow at the Center for Internet Technology Policy at Princeton University. Her forthcoming book from Yale University Press is tentatively titled Beautiful Tear Gas: The Ecstatic, Fragile Politics of Networked Protest in the 21st Century.
Serbest Mitokondriyal Dna nın Sistemik Dolaşımdaki Rolü Ve Hastalıkların Patogenezine Etkisi

Mitochondria are multi-functional organelles with many essential roles in the maintenance of cell viability as well as ATP production by oxidative phosphorylation. One of the most important features of this organelle that contributes to cell viability is its own genetic system. Mitochondrial DNA (mtDNA), which is located in the mitochondrial matrix under normal physiological conditions, is released into the extracellular matrix and enters the systemic circulation in case of an organelle and/or a cellular damage. Recent studies have focused on the role of mtDNA in circulation and its association with diseases. Circulating cell-free mtDNA (ccf-mtDNA) is regarded as a Damage Associated Molecular Pattern (DAMP) and recognised by the Pattern Recognition Receptors (PRRs). They play a fundamental role in initiating the pro-inflammatory response. In this review, the mechanisms of ccf-mtDNA-induced inflammatory pathways in systemic circulation and the effect of ccf-mtDNA on diseases pathogenesis will be discussed.
FEATURES OF DYSLIPIDEMIA AND ITS INFLUENCE ON ENDOTHELIUM FUNCTIONAL STATE IN PATIENTS WITH RHEUMATOID ARTHRITIS AND ARTERIAL HYPERTENSION

Abstract Purpose of the study. Was to identify the features of blood lipid spectrum and endothelium functional state in patients with rheumatoid arthritis (RA) and arterial hypertension (AH). Materials and methods. 83 patients were examined (40 with RA combined with AH, 23 with RA and 20 with AH). The blood lipid spectrum and endothelial function were studied in all patients. Results. The analysis of blood serum lipid parameters demonstrated that in patients with RA, regardless of the presence of AH, there was a significant increase of proatherogenic lipid profile parameters in comparison with those in healthy subjects. It was shown, that lower concentrations of high-density lipoproteins and higher atherogenic coefficient indices was a characteristic feature of the lipid profile in RA patients both with and without AH - in contrast to the same parameters of the lipid spectrum in patients with AH without RA. In the groups of patients with RA a significant increase of the brachial artery diameter at rest and decreased indices of endothelium-dependent vasodilation and endothelium-independent vasodilation were revealed. Subjects with RA in combination with AH had significantly lower indices according to the tests with both reactive hyperemia and nitroglycerin, while in patients with RA without AH, only NG-test was significantly lower. Conclusion. Dyslipidemia of atherogenic type and endothelial dysfunction develops at the initial stages of rheumatoid process and depends on the activity of the inflammatory process, the presence of extra-articular manifestations and rheumatoid factor seropositivity. Keywords: rheumatoid arthritis, arterial hypertension, dyslipidemia, endothelial dysfunction.
Online capacity planning of repairs

In this thesis we describe our research into a capacity planning problem that occurs in practice at a big group of car dealers, the Ruttchen group. A considerable part is about the construction of a model for this problem, showing and justifying the assumptions we make. Then it is shown that this model can be written as a Linear Program. We end by investigating related models, and show how we can solve them as either maximum flow problems, or with the help of a self-constructed algorithm based on finding augmenting paths with possibly additional cycles.
Bioactivities and molecular networking-based elucidation of metabolites of potent actinobacterial strains isolated from the Unkeshwar geothermal springs in India

The bioactive potential of Actinobacteria endemic to hot springs has rarely been investigated. This study highlights the cultivable diversity and bioactivities of Actinobacteria associated with the Unkeshwar hot springs, India. Potent strains were evaluated for their biosynthetic potentials and metabolite analysis was performed using effective dereplication molecular networking tools. A total of 86 actinobacterial strains were isolated and grouped into 21 distinct genera, based on 16S rRNA gene sequence analysis. These strains included rare members such as Micromonospora, Marmoricola, Actinomadura, Cellulomonas, Cellulosimicrobium, Janibacter, Rothia, Barrentisimonas, Dietzia and Glycomyces. In antimicrobial screening, Micromonospora sp. strain GH99 and Streptomyces sp. strain GH176 were found to be potent antimicrobial strains. The metabolic extracts of these strains exhibited strong antimicrobial activity against Staphylococcus epidermidis (NCIM 2493), Shigella flexneri (NCIM 5265), Klebsiella pneumonia (NCIM 2098), and Salmonella abony (NCIM 2257). The extracts also displayed strong anti-biofilm and anticancer activities against Pseudomonas aeruginosa (NCIM 5029), Acinetobacter junii (NCIM 5188) and breast cancer cell line MCF7, respectively. Both strains also tested positive for the presence of the PKS biosynthetic gene cluster in their genomes. To effectively delineate the secondary metabolites, the extracts were subjected to MS/MS-guided molecular networking analysis. Structurally diverse compounds including the polyketides 22-dehydroxymethyl-kijanolide (GH99 strain) and Abyssomicin I (GH176 strain) were detected in the extracts. Interestingly, Brevianamide F was detected in the extract of Micromonospora, which has previously been mostly found in fungal species. Other compounds such as cyclic tripeptides, Cyclo(l-Pro-d-Ile) and Cyclo(d-Pro-l-Phe), were also identified in this strain. In summary, for the first time, we explored the diversity of Actinobacteria and evaluated their bioactive potential from the Unkeshwar hot springs. The potent strains isolated in the study could be useful in drug discovery programs.
The experimental study of the pathogenic role of NADPH-oxidase in the thyroid gland tissues

L’objectif de l’étude était de comparer le système NADPH / H2O2 et l’expression des enzymes, dans la culture de cellules de la glande thyroïde, en fonction du sexe. Méthodes. La glande thyroïde a été prélevée chez des donneuses adultes (n = 20) et des hommes (n = 15). Les cellules ont été lavées deux fois avec du HBSS et centrifugées à 1000 xg pendant 5 minutes, puis cultivées à 106 cellules dans 0,5 ml de milieu de culture par puits dans des plaques à 24 puits (Thermo Fisher Scientific, USA). Les niveaux de H2O2 dans les cellules ont été déterminés de manière quantitative à l’aide d’un capteur de peroxyde d’hydrogène Premo TM Orp1-roGFP (Life Technologies, USA) conformément aux instructions du fabricant. L’analyse statistique des résultats a été réalisée avec Statistica 6.1 (StatSoft, Inc., USA). Résultats. Nous avons constaté que l’expression de DUOX1 et de NOX4 était significativement plus élevée chez les femmes par rapport aux hommes (1,5 fois, p <0,05). L’expression de DUOX2 dans les cellules femelles était 1,5 fois plus élevée que celle des hommes mais statistiquement significative (p = 0,06). Nous ABSTRACT
An effector-reporter system to study cellular cellular signal transduction in strawberry fruit (Fragaria ananassa)﻿

Background: An effector-reporter system is a powerful tool used to study cellular signal transduction; however, this technique has been traditionally adopted in protoplasts. A similar system to study cellular signal transduction in fruits has not yet been established. In this paper, we aim to establish an effector-reporter system for strawberry fruit, a model non-climacteric fruit.Results: We compared four different reporters, including GUS, GFP, FLuc, and RLuc, as well as combination of two pairs of reporters, including GUS/GFP and RLuc/FLuc, by statistically analyzing the pattern of reporter activities exhibited among individual fruits. Among the reporters examined, GUS was the best choice. Further sampling indicated that a minimum of five mixed specimens with five fruits each is necessary for an assay. With the so-established system, FaCHS promoter demonstrated a sensitive response to FaMYB10 effector as well as to the external and internal cues implicated in the regulation of fruit ripening.Conclusion: A step-by step protocol was established to study cellular signal transduction in strawberry fruits. This finding will contribute to the molecular investigation of fruit ripening.
Start Data entry Excel sheets Voltage calculate Finish Is low-voltage ? N Control measures

With the rapid development of urban economy, distribution network construction of city is lagging behind the increment of load, and low-voltage problem has become the main complaints of the power users. Based on Python [1] scripting language, this paper develops a piece of software which can provide a friendly human-machine experience for the user, calculate the voltage of the power distribution area and propose corresponding control measures, then the paper takes the actual power distribution area to verify its effectiveness.
Extensive memory testing improves prediction of progression to MCI in late middle age

INTRODUCTION Predicting risk for Alzheimer’s disease when most people are likely still biomarker negative would aid earlier identification. We hypothesized that combining multiple memory tests and scores in middle-aged adults would provide useful, and non-invasive, prediction of 6-year progression to MCI. METHODS We examined 849 men who were cognitively normal at baseline (mean age=55.69±2.45). RESULTS California Verbal Learning Test learning trials was the best individual predictor of amnestic MCI (OR=4.75). A latent factor incorporating 7 measures across 3 memory tests provided much stronger prediction (OR=9.88). This compared favorably with biomarker-based prediction in a study of much older adults. DISCUSSION Neuropsychological tests are sensitive and early indicators of Alzheimer’s disease risk at an age when few individuals are likely to have yet become biomarker positive. Single best measures may appear time- and cost-effective, but 30 additional minutes of testing, and use of multiple scores within tests, provides substantially improved prediction
Exploring the giant circle on the high bar with ICT tools

Daan Knobbe and Nic Nijdam were secondary school students with artistic gymnastics as a hobby. They jointly investigated the mechanics of the gymnastics swing around the high bar. They not only did this to meet the curriculum requirement of a carrying out a large research project, but also to satisfy their curiosity regarding the sports science subject. With a high-speed camera they recorded the motion of a backward giant circle on the high bar. Hereafter they analysed their data both quantitatively and qualitatively. We present the results of the students’ research work about the backward giant circle on the high bar, which resembled the practice of sports scientists. We discuss the authenticity of this project, the role of ICT, and potential further exploration at student level. In our opinion, the presented work is a nice illustration of authentic experiences of secondary school students in doing sports science that they will never forget.