Miracle-dz/UniFAR-FTUs huggingface dataset:
Bayesian MCPMod

Multiple comparison procedures and modeling (MCPMod) has established itself as a method for dose‐finding under model uncertainty. A downside of MCPMod is that due to its frequentist nature in particular with respect to the multiple comparison part it is tough to incorporate historical information in a systematic fashion. A typical situation where such historical information is available is existing data for the placebo group from previous trials. There are multiple Bayesian concepts for integrating historical data in a systematic and even dynamic fashion like the meta‐analytic prior approach. In this article, we define Bayesian MCPMod (BMCPMod) that is build upon these two aspects. BMCPMod is able to mimic the results of the classical MCPMod for non‐informative priors. At the same time, it allows for the inclusion of historical data in a systematic fashion. After the definition of BMCPMod related characteristics for a Bayesian approach similar to the MCP‐testing part are derived. The BMCPMod is compared to classical MCPMod/non‐informative priors via simulations. Aspects of mixture priors, optimal contrast vectors, and impact of allocation ratios are discussed and an example for designing a BMPCMod trial is given.
Particle Focusing in a Straight Microchannel with Non-Rectangular Cross-Section

Recently, studies on particle behavior under Newtonian and non-Newtonian fluids in microchannel have attracted considerable attention because particles and cells of interest can be manipulated and separated from biological samples without any external force. In this paper, two kinds of microchannels with non-rectangular cross-section were fabricated using basic MEMS processes (photolithography, reactive ion etching and anisotropy wet etching), plasma bonding and self-alignment between two PDMS structures. They were used to achieve the experiments for inertial and elasto-inertial particle focusing under Newtonian and non-Newtonian fluids. The particle behavior was compared and investigated for different flow rates and particle size in the microchannel with rhombic and equilateral hexagonal cross section. We also investigated the influence of Newtonian fluid and viscoelastic fluid on particle migration in both microchannels through the numerical simulation. The experimental results showed the multi-line particle focusing in Newtonian fluid over a wide range of flow rates, but the single-line particle focusing was formed in the centerline under non-Newtonian fluid. The tighter particle focusing appeared under non-Newtonian fluid in the microchannel with equilateral hexagonal cross-section than in the microchannel with rhombic cross section because of the effect of an obtuse angle. It revealed that particles suspended in the channel are likely to drift toward a channel center due to a negative net elasto-inertial force throughout the cross-sectional area. Simulation results support the present experimental observation that the viscoelastic fluid in the microchannel with rhombic and equilateral hexagonal cross-section significantly influences on the particle migration toward the channel center owing to coupled effect of inertia and elasticity.
The contamination of DEHP on the surfaces of PVC sheet and risk of infants

ABSTRACT This study conducted laboratory tests and field surveys to understand the plasticizer contamination characteristics on the surface of PVC flooring materials used indoors, and discussed the risk of exposure of plasticizers to infants indoors. A lab experiment was conducted to measure the bleed-out of DEHP on PVC sheet surfaces. As a result of the bleed-out, the amount of DEHP on the specimen surfaces was 432 to 880 [ug/m2]. The present study showed that plasticizers such as DEHP contained in the PVC sheet accumulate a significant amount of DEHP on the surface of the PVC sheet even if a material such as house dust is not present on the surface of the PVC sheet. In addition, this study found that even if the dust accumulated on the PVC floor surface was vacuumed, it was difficult to completely remove the DEHP accumulated on the floor surface. The field surveys showed that the average concentration of DEHP on the floor surface in Korean and Japanese house were 356 and 608 ug/m2 respectively. Since infants have behavioral characteristics of crawling, sitting, and lying on the floor, they have more opportunities to directly contact the floor than adults.
TEACHERS' VIEWS ON THE EVALUATION OF LITERACY TEACHING DURING THE COVID-19 PANDEMIC

At the end of 2019, the coronavirus, which affected the whole world, started to spread in Turkey with the first cases seen as of March. With the spread of the virus, almost all public and private institutions and organizations have taken some precautions. In this process, the Ministry of National Education has also taken some measures within its own body. Most of the second semester of the 2019-2020 academic year was carried out with distance education. At the beginning of the new academic year, although the schools remained open from time to time, they were closed most of the year and the studies were carried out remotely. In the 2020-2021 academic year, first-year students also learned to read and write for the first time through distance education, although there was no such experience before. In the study, the views of teachers on primary literacy teaching during the epidemic period were examined. In this context, the aim of the research is to determine the opinions of the teachers about the first literacy teaching carried out with distance education activities during the epidemic period. The research was carried out with 10 teachers who experienced literacy teaching during the epidemic period, and the data obtained were subjected to content analysis. According to the findings of the study, connection problems, problems in family communication, and wrong intervention of families in the process were identified as problems. The opportunity to work one-on-one with students is seen as the advantage of this process. Teachers used web 2.0 tools, presentations, different platforms. Although a target close to face-to-face has been achieved in reading teaching, it has not been successful at the same rate in writing teaching. The teachers carried out the process by using student-centered methods and techniques such as gamification and individual teaching. Article visualizations:
PTSD in the Newsroom: A Grounded Theory View of Organizational Leaders and Trauma

ABSTRACT A number of studies have demonstrated that journalists will experience traumatic events during the course of their careers. Yet a gap in the research exists regarding newsroom organizational leaders and the impact of trauma on their work and emotional health. This study used a grounded theory approach to learn how newsroom leaders experience trauma and how they learn from events such as disasters and terror attacks to translate that knowledge into the work of management. The study also analyzes peer-reviewed research on journalism, trauma, and PTSD to understand how the newsroom organizational leaders in the study can contribute and amplify the recommended trauma responses for newsroom leaders. The data reveal that news organizational leaders can experience symptoms of PTSD and other negative emotional impacts and that news organizational leaders experience an emotional double bind, where staff is encouraged to openly show emotion and be supported, but the organizational leaders believe they will be perceived as weak if they show emotion. Findings from the study are valuable, because they lead to practical guidelines regarding counseling, supervisor support, and training and extend our understanding of how trauma can impact the entire newsroom ecosystem.
A rare variant in the MARVELD2 gene is associated with Chinese samples with ovarian endometriosis

Objectives: Endometriosis is a common gynecological disease affecting up to ~10% of women at reproductive age. Prior combined studies implied that MARVELD2 might be involved in the pathogenesis of certain malignancies. Here, 211 Han Chinese samples with ovarian endometriosis were analyzed for the presence ofMARVELD2 mutations. Methods: We analyze the potential presence ofMARVELD2 mutations by direct DNA sequencing. Results: A total of 7 variants, 5 missense and 2 synonymous variants, were identified in our 211 ovarian endometriosis samples with different frequencies. Among the 5 missense variant, a missense rare variant p.V198M (c.592G>A), was identified in 10 out of our 211 samples (4.74%). This rare variant was identified with extremely low frequency in 766 control samples from 766 Chinese women without endometriosis (0.13%, 1/766) and control samples in the public databases. The evolutionary conservation analysis results suggested that theMARVELD2 rare variant lead to highly conserved amino acid substitutions among 14 vertebrate species from Human to Snake. Furthermore, both the SIFT and Polyphen-2 programs predicted this rare variant to be ‘disease causing’. However, we failed to observe any statistical significance between the MARVELD2 rare variant and the available clinical data. Conclusions: We identified a potential pathogenic rare variant in the MARVELD2 gene in Chinese samples with ovarian endometriosis, indicating theMARVELD2 rare variant might play an active role in the pathogenesis of endometriosis.
Knowledge and attitudes towards sexually transmitted illnesses (STIs) among the general population of Saudi Arabia

Background: We aim to determine the level of general knowledge and attitudes among the population of Saudi Arabia regarding sexually transmitted illnesses (STI). In addition, we aim to educate participants about the most common STIs, and explore how this influences the participants’ attitudes and perceptions. Methods: This study is a cross-sectional web-based survey of the general population of Saudi Arabia. The sample was enrolled randomly by distributing the survey through social media over a two-month period. 420 subjects between the ages of (15–60) participated in the study. Results: Among the 420 total responses, 405 (96%) participants were included based on the absence of missing data in their answers. Most of the participants (77%) were females. More than half of the respondents were single (59%), 24 years old or more (57%), Saudi (52%), and had a bachelor’s degree (65%). Forty-eight percent (48%) of the participants were related to the medical field. Only 11% knew someone previously diagnosed with STIs. The mean score of overall knowledge about STI was 8.79 ± 3.17 (median = 9) out of a maximum score of 20. The scores ranged from 2–16. A higher percentage of the participants (48.6%) had a low level of knowledge. Two-hundred eighty-one participants showed interest in viewing the attached educational material and subsequently completed questions on attitude regarding STI education. The mean score for attitude was 5.89 ± 1.52 out of a total of 7 (median = 6). Around 73% of all participants had a positive attitude towards STI education. Conclusion: Our findings suggest that targeting the younger population by incorporating STI-related educational material into school curricula would overcome the stigma associated with these illnesses by raising awareness and improving attitude towards them.
The Cinemapoetics of the modern Ukrainian novel: Myroslav Dochynets’ creative works

The article presents a review of the Ukrainian literary critics’ works on the relationship between literature and cinema, the relevance and effectiveness of the practice of involving cinematic resources in the literary works of Ukrainian writers of the 20th – early 21st centuries. On the material of the novels “Centenarian. Confession on the Pass of the Spirit”, “Svitovan. Studies under the Tent of the Skies”, “Well-Digger. Diary of the Richest Resident of Mukachevo Dominion”, “Highlander. Waters of Our Lord’s Riverbeds”, “Maftei. Book Written with a Dry Pen” by the contemporary Ukrainian writer M. Dochynets traces the problem of inter-artistic interaction of literature and cinema. The purpose of the research is to single out and analyze film frame, montage, shot, perspective, rhythm as integral elements of the cinematic poetics of M. Dochynets ’prose, which are used in the text to reveal the artistic, aesthetic, philosophical and creative principles of the writer. The study used general scientific (analysis, synthesis, comparison) and literary methods: the systematic approach, hermeneutic method, principles of narratology, intermedia approach. Appealing to the works of O. Chicherin, S. Eisenstein, Yu. Lotman, M. Romm, A. Tarkovsky, etc., the peculiarities of the use of film poetics in the writer’s novels are analyzed. It was found out that in prose by M. Dochynets montage, film frame, shot, rhythm, foreshortening perform intonation-expressive, plot-compositional and characterological functions.
Dietary Supplementation with γ-Aminobutyric Acid Improves Growth, Digestive Enzyme Activity, Non-Specific Immunity and Disease Resistance against Streptococcus iniae in Juvenile Olive Flounder, Paralichthys olivaceus

Simple Summary γ-aminobutyric acid (GABA) is a very important biomolecule that is found in all lifeforms and serves innumerable essential biological functions in pathways ranging from neural transmission to metabolism and immunity. In recent years, GABA was identified as an important metabolite involved in the modulation of the gut microbiome, and even appetite, in fish. The current trial aims to assess the effects of GABA as a supplement for nutritionally important biomarkers of fish health. Our results show that approximately 229–282 mg/kg of the total dietary GABA has important benefits for juvenile olive flounder, most significantly with improved disease resistance against Streptococcus iniae. Abstract Recent research is increasingly shedding light on the important role that microbial metabolites such as γ-aminobutyric acid (GABA) play in the context of nutrition, cognition, immune function, and the modulation of the gut microbiome. Yet, very few trials were conducted to assess the effects of its supplementation on biomarkers of fish health. Therefore, an eight-week feeding trial was devised to evaluate GABA supplementation in juvenile olive flounder, (Paralichthys olivaceus). A total of 630 fish with an average weight of 4.90 ± 0.10 g (±SD) were randomly assigned to one of seven triplicate groups and fed a non-GABA supplemented diet (CON, with 92 mg/kg GABA content), a positive control with 4 g/kg oxytetracycline (OTC), and five other diets supplemented with 50, 100, 150, 200 and 250 mg/kg GABA (corresponding to a total GABA content of 154, 229, 282, 327 and 352 mg/kg, respectively). Growth, blood chemistry, nonspecific immunity, digestive enzyme activity and disease resistance were assessed. The results showed that 100 and 150 mg/kg GABA supplementation consistently yielded significant improvements (p < 0.05) in growth, intestinal amylase, serum lysozyme, and survival against infection with Streptococcus iniae. Based on polynomial analysis, the optimal supplementation level was determined to be 237 mg/kg. These results support GABA as an important functional feed additive in juvenile olive flounder.
The Use of Bioactive Compounds in Hyperglycemia- and Amyloid Fibrils-Induced Toxicity in Type 2 Diabetes and Alzheimer’s Disease

It has become increasingly apparent that defective insulin signaling may increase the risk for developing Alzheimer’s disease (AD), influence neurodegeneration through promotion of amyloid formation or by increasing inflammatory responses to intraneuronal β-amyloid. Recent work has demonstrated that hyperglycemia is linked to cognitive decline, with elevated levels of glucose causing oxidative stress in vulnerable tissues such as the brain. The ability of β-amyloid peptide to form β-sheet-rich aggregates and induce apoptosis has made amyloid fibrils a leading target for the development of novel pharmacotherapies used in managing and treatment of neuropathological conditions such as AD-related cognitive decline. Additionally, deposits of β-sheets folded amylin, a glucose homeostasis regulator, are also present in diabetic patients. Thus, therapeutic compounds capable of reducing intracellular protein aggregation in models of neurodegenerative disorders may prove useful in ameliorating type 2 diabetes mellitus symptoms. Furthermore, both diabetes and neurodegenerative conditions, such as AD, are characterized by chronic inflammatory responses accompanied by the presence of dysregulated inflammatory biomarkers. This review presents current evidence describing the role of various small bioactive molecules known to ameliorate amyloidosis and subsequent effects in prevention and development of diabetes and AD. It also highlights the potential efficacy of peptide–drug conjugates capable of targeting intracellular targets.
Using sport science data in collegiate athletics: Coaches’ perspectives

Limited research has examined American collegiate coaches’ perceptions of collecting data for informing training practices. The purpose of this study was to examine collegiate coaches’ perspectives and needs for collecting data from their athletes using a qualitative approach. Four focus groups were conducted with NCAA Division I coaches (N = 13) at a mid-sized liberal arts university. Coaches were asked how they could benefit from collecting data from their athletes, how they would use the data to answer questions about athletes’ performance, what data they would want to collect, and what concerns they had regarding data collection. Principles of thematic analysis were used to analyze the interviews. Most coaches (54%) felt that collecting data would provide evidence needed to support training methodologies, and they would benefit (i.e. make improvements to coaching and athlete training) from monitoring progress in their athletes (61%). Regarding performance questions, coaches were interested in utilizing a biomechanist to conduct movement analyses (23%) and assessing athletes’ mental and emotional states (23%). Coaches wanted to monitor athletes’ fatigue, recovery, mental health states, and health behaviors (i.e. sleep and diet; 15%). Coaches expressed concerns over finding an optimal time to test athletes (8%) and effective presentation of data to athletes (23%) while limiting body composition assessments due to athlete discomfort (15%). Findings from these focus groups suggest that coaches would like to collect data to learn more about athletes’ physical and mental states, but several logistical and practical concerns still exist regarding how to efficiently collect and utilize the data.
Current Trends in Hypertension: Takeaways from the 2021 KDIGO Guidelines for the Management of Blood Pressure in Chronic Kidney Disease

The new 2021 Kidney Disease Improving Global Outcomes (KDIGO) guidelines on the management of blood pressure in chronic kidney disease (CKD) patients were published in March 2021 in Kidney International. The full issue exceeds 80 pages. The author of this article aims to provide a succinate summary of the main points of the guidelines with special emphasis on the changes introduced since the previous 2012 guidelines. These KDIGO guidelines are evidence-based, and they are graded accordingly. As with any recent hypertension guidelines, they incorporate and emphasize the results of The Systolic Blood Pressure Intervention Trial (SPRINT) published in 2015.
Arrangement of Makassar City Water Sports Tour Packages based on Geographic Information Systems

This study aims to model the Tirta Tour package in Makassar City. This research method uses a qualitative approach, the data sources are obtained through surveys with field notes, interviews and documentation, while the data processing techniques use the help of ArcGIS 10.5 software. The data collection techniques used in this study are: Focus Group Discussion (FGD), interviews, study comparison and literature study were used for qualitative data. Based on the processed data, it was found as follows: 1) Water tourism potential in Makassar City as a result of analysis 3A: Accessibility, Amenity and Activities in general, the cluster of islands in the Spermonde Archipelago has the potential to become superior marine tourism with current conditions it can be said to be natural. heritage landscapes. 2) Mapping model for Tirta Tour Packages in Makassar City in the form of Tirta Travel Routes with a Stopover Movement Pattern with 4 Tourist Attractions. This study recommends the preparation of an online water tourism information system for Makassar City so that it can be accessed anytime and anywhere. KEY WORDS: Tirta Tourism; Mapping; Tour Packages
The International Journal of Environmental, Cultural, Economic, and Social Sustainability: Annual Review

The objective of this paper is to examine the trade-offs between economic, social, and environmental objectives of increased environmental flows of water in the Murray-Darling system (Australia’s largest river system). The Murray-Darling Basin Authority has proposed a transfer of between 3,000 ML and 6,700 ML from irrigation to environmental flows. Many farmers consider the costs of even the smallest transfer to be prohibitive, while many conservationists regard even the largest transfer as insufficient to capture any significant environmental benefits. The paper examines published work to shed light on the nature of the trade-offs involved in this proposed transfer of water to the environment. Preliminary work indicates a number of hypotheses that are worthy of further examination. First, several estimates suggest that the costs to farming will be small as long as irrigation water is purchased at its full market value. Second, there appeared to be significant thresholds of environmental water flows which would be required to capture any worthwhile environmental benefits. Third, under various proposed compensation schemes, communities overall in the Murray-Darling Basin may benefit (rather than lose) from transfers of water within the above range. Fourth, there would be some losers from the transfer, especially those dependent on irrigated agriculture who have no irrigation entitlements. This would include local businesses supplying services to irrigated agriculture. These are the key issues examined in the paper.
Narratives imagined in response to instrumental music reveal culture-bounded intersubjectivity

Significance Are we all imagining the same thing when we listen to music, or are our experiences hopelessly subjective? This research analyzes the similarity of responses from 622 participants in three locations on a highly unconstrained task: free-response descriptions of the stories they imagined while listening to instrumental music. Strikingly, participants in two separate locations that share an overarching culture imagine highly similar narratives to individual excerpts. But these similarity patterns do not extend to narratives imagined by participants in a third location with a distinct culture. This work shows that music—often considered an “abstract stimulus”—can trigger shared stories in listeners’ minds but that this intersubjectivity depends on a shared underlying culture. The scientific literature sometimes considers music an abstract stimulus, devoid of explicit meaning, and at other times considers it a universal language. Here, individuals in three geographically distinct locations spanning two cultures performed a highly unconstrained task: they provided free-response descriptions of stories they imagined while listening to instrumental music. Tools from natural language processing revealed that listeners provide highly similar stories to the same musical excerpts when they share an underlying culture, but when they do not, the generated stories show limited overlap. These results paint a more complex picture of music’s power: music can generate remarkably similar stories in listeners’ minds, but the degree to which these imagined narratives are shared depends on the degree to which culture is shared across listeners. Thus, music is neither an abstract stimulus nor a universal language but has semantic affordances shaped by culture, requiring more sustained attention from psychology.