Miracle-dz/UniFAR-FTUs huggingface dataset:
Chelation Therapy for Kidney Transplant Recipients With Lead Exposure.

We are grateful to Drs Ju-Shao Yen and Tzung-Hai Yen for their appraisal of our article. The authors suggest that plasma samples are suboptimal for body exposure evaluation compared to whole-blood samples, based on a study in which withinand betweenvariation of various lead biomarkers were compared using inductively coupled plasma mass spectrometry equipment introduced in 2001. Given the tremendous and still ongoing improvements in this field, the only valid conclusion of the study from Sommar et al is that total variance in whole-blood lead concentrations is largely attributable to inter-individual differences; in terms of plasma concentrations, the equipment that was used does not allow for valid conclusions that can be extended to more recent equipment. An equipmentindependent way to judge between the use of plasma or whole-blood lead samples for body exposure evaluation would be to assess the longitudinal association of exposure with different health effects, but the work by Sommar et al did not address this question. Importantly, previous studies suggest a stronger correlation for plasma rather than whole-blood specimens, advocating for the use of the former. We previously argued that plasma concentrations of heavy metals reflect the fraction most freely available to form the ultrafiltrate to which kidney tubular epithelial cells are exposed, and which would be the source of toxicity. We now applied the same line of reasoning to lead exposure, like others did before. It should furthermore be underlined that we studied kidney transplant recipients rather than the general population. Our article discusses how the posttransplant osteodystrophy common to transplant recipients may argue for use of plasma samples. Despite these considerations, we acknowledge that the question of which biomarker can best Correspondence
Application of GARCH and mean-variance model in the U.S. financial market

How to obtain a high return and face the low-risk investment is a hot topic widely discussed among investors. However, the specific method of targeting the optimal portfolio requires sophisticated mathematical computations. By research, some scholars found that the theory of portfolio helps investors to get a higher return and reduce investment risk. Thus, the aim of this paper is to collect and optimize a selected portfolio—Apple, Google, Netflix, Tesla, and Walmart—by GARCH model and Sharpe ratio, based on the mean returns and correlation matrix, among which Google and Apple are strongly positively correlated to each other, while Walmart, Tesla, and Netflix are weakly positively correlated. The price return of GARCH volatility of each equity shows the stock returns will go down in the next 7 days. We compare the optimal portfolio with NASDAQ composite to find the superiority of our model.
The detection of discrete cyclotron emission features in phase-resolved optical spectroscopy of V1500 Cygni

We have obtained phase-resolved optical spectroscopy of the old nova, and asynchronous polar V1500 Cyg. These new data reveal discrete cyclotron humps from two different strength magnetic fields. One region has B = 72 MG, while the other has B ~ 105 MG. With the detection of these features, we revisit the optical/near-IR light curves presented in Harrison & Campbell (2016), and find that the large photometric excesses observed in those data are fully reconcilable with cyclotron emission. These results, when combined with the X-ray observations that appeared to have maxima that repeated on the orbital period, imply that V1500 Cyg has reverted back to a synchronous polar. Using existing theory, we show that the strong field strengths found here can explain the rapid spin down time.
Origins of quasars and galaxy clusters

The distribution on the sky of clusters of galaxies shows significant association with relatively nearby, large, active galaxies. The pattern is that of clusters paired equidistant across a central galaxy with the apparent magnitudes and redshifts of their constituent galaxies being closely matched. The clusters and the galaxies in them tend to be strong X-ray and radio emitters and their redshifts occur at preferred redshift values. The central, low redshift galaxies often show evidence of ejection in the direction of these higher redshift clusters and the clusters often show elongation along these lines. In most of these respects the clusters resemble quasars which have been increasingly shown for the last 34 years to be similarly associated with active parent galaxies. It is argued here that, empirically, the quasars are ejected from active galaxies. They evolve to lower redshift with time, fragmenting at the end of their development into clusters of low luminosity galaxies. The cluster galaxies can be at the same distance as their lower redshift parents because they still retain a component of their earlier, quasar intrinsic redshift.
Highly Specific Peptide-Mediated Cuvette-Form Localized Surface Plasmon Resonance (LSPR)-Based Fipronil Detection in Egg

Herein, we have developed peptide-coated gold nanoparticles (AuNPs) based on localized surface plasmon resonance (LSPR) sensor chips that can detect fipronil with high sensitivity and selectivity. The phage display technique has been exploited for the screening of highly specific fipronil-binding peptides for the selective detection of the molecule. LSPR sensor chips are fabricated initially by attaching uniformly synthesized AuNPs on the glass substrate, followed by the addition of screened peptides. The parameters, such as the peptide concentration of 20 µg mL−1 and the reaction time of 30 min, are further optimized to maximize the efficacy of the fabricated LSPR sensor chips. The sensing analysis is performed systematically under standard fipronil solutions and spike samples from eggs. The developed sensor has shown excellent sensitivity towards both standard solutions and spike samples with limit of detection (LOD) values of 0.01 ppb, respectively. Significantly, the developed LSPR sensor chips offer distinct features, such as a facile fabrication approach, on-site sensing, rapid analysis, cost-effectiveness, and the possibility of mass production, in which the chips can be effectively used as a promising and potential on-site detection tool for the estimation of fipronil.
Recent Advances in Exosomal miRNA Biosensing for Liquid Biopsy

As a noninvasive detection technique, liquid biopsy plays a valuable role in cancer diagnosis, disease monitoring, and prognostic assessment. In liquid biopsies, exosomes are considered among the potential biomarkers because they are important bioinformation carriers for intercellular communication. Exosomes transport miRNAs and, thus, play an important role in the regulation of cell growth and function; therefore, detection of cancer cell-derived exosomal miRNAs (exo-miRNAs) gives effective information in liquid biopsy. The development of sensitive, convenient, and reliable exo-miRNA assays will provide new perspectives for medical diagnosis. This review presents different designs and detection strategies of recent exo-miRNA assays in terms of signal transduction and amplification, as well as signal detection. In addition, this review outlines the current attempts at bioassay methods in liquid biopsies. Lastly, the challenges and prospects of exosome bioassays are also considered.
In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds

Scaffold hydrogel biomaterials designed to have advantageous biofunctional properties, which can be applied for controlled bioactive agent release, represent an important concept in biomedical tissue engineering. Our goal was to create scaffolding materials that mimic living tissue for biomedical utilization. In this study, two novel series of interpenetrating hydrogel networks (IPNs) based on 2-hydroxyethyl methacrylate/gelatin and 2-hydroxyethyl methacrylate/alginate were crosslinked using N-ethyl-N′-(3-dimethyl aminopropyl)carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS). Characterization included examining the effects of crosslinker type and concentration on structure, morphological and mechanical properties, in vitro swelling, hydrophilicity as well as on the in vitro cell viability (fibroblast cells) and in vivo (Caenorhabditis elegans) interactions of novel biomaterials. The engineered IPN hydrogel scaffolds show an interconnected pore morphology and porosity range of 62.36 to 85.20%, favorable in vitro swelling capacity, full hydrophilicity, and Young’s modulus values in the range of 1.40 to 7.50 MPa. In vitro assay on healthy human fibroblast (MRC5 cells) by MTT test and in vivo (Caenorhabditis elegans) survival assays show the advantageous biocompatible properties of novel IPN hydrogel scaffolds. Furthermore, in vitro controlled release study of the therapeutic agent resveratrol showed that these novel scaffolding systems are suitable controlled release platforms. The results revealed that the use of EDC and the combination of EDC/NHS crosslinkers can be applied to prepare and tune the properties of the IPN 2-hydroxyethyl methacrylate/alginate and 2-hydroxyethyl methacrylate/gelatin hydrogel scaffolds series, which have shown great potential for biomedical engineering applications.
Hawking temperature of the cosmological horizon in a FRW universe

It is well known that there is a Hawking temperature on the cosmological horizon of the de-sitter spacetime, and the de-sitter spacetime can be a special case of a FRW universe. Therefore, there may be a corresponding Hawking temperature in a FRW universe. Indeed, there have been several clues showing that there is a Hawking temperature on the apparent horizon of a FRW universe. In our paper, however, after finding the corresponding cosmological horizon of a FRW universe, and then investigating the behavior of a Klein-Gordon field near the cosmological horizon, we find that there is a Hawking temperature on the cosmological horizon. Moreover, we also find that the Hawking temperature on the apparent horizon of a FRW universe in some previous work is just a special case in our results, where the variation rate of cosmological horizon . rH is zero.
An improved modal approach for model reduction based on input-output relation

An approximated model of a large scale dynamical system captures its main features by a proper selection of its dominant modes. In this paper, a new metric is presented for modal dominancy analysis. This metric is an explicit formulation for evaluating the participation of each mode, independent from the other modes, into the output. Only eigensolutions with a large contribution to this metric, the dominant eigensolutions, will be retained in the approximating lower order model. The modal truncation technique which includes the proposed dominancy analysis not only has a metric for error estimation, but is able to automatically detect and eliminate unobservable and uncontrollable modes. An example from finite element analysis of an aluminum plate illustrates the approach and shows that the proposed method is very efficient in respect to computational time.
Prerequisite for Accountability: Access to Information in the German European Affairs Council

Negotiations in the Council of the European Union have been described as non-transparent since access to certain documents concerning the deliberations is restricted. As a result, national parliaments struggle to hold their national governments to account. Parliaments, providing a direct link between voters and the executive, play a vital role in granting legitimacy to the EU. Their incapacity weakens the democratic legitimacy of the European project. Existing literature on the topic has examined the formal powers of national parliaments and how active they are. However, it has failed to explore their access to information. This paper analyses the access to information on deliberations in the Council by the German European Affairs Committee (EAC) in the Bundestag. Interviews were conducted with members of the German EAC and their EU policy advisors. The analysis revealed that the German EAC employs an extensive network of direct oversight, manually scrutinizing a large number of documents. Certain limitations of this method were revealed, as due to capacity constraints only select decisions were examined. Individual citizens, organized interest and the media were shown to play a role in triggering the oversight at times, thus providing the impetus to start the scrutiny process.
Modelling Identity Disturbance: A Network Analysis of the Personality Structure Questionnaire (PSQ)

Due to the relevance of identity disturbance to personality disorder this study sought to complete a network analysis of a well validated measure of identity disturbance; the personality structure questionnaire (PSQ). A multi-site and cross-national methodology created an overall sample of N = 1549. The global network structure of the PSQ was analysed and jointly estimated networks were compared across four subsamples (UK versus Italy, adults versus adolescents, clinical versus community and complex versus common presenting problems). Stability analyses assessed the robustness of identified networks. Results indicated that PSQ3 (unstable sense of self) and PSQ5 (mood variability) were the most central items in the global network structure. Network structures significantly differed between the UK and Italy. Centrality of items was largely consistent across subsamples. This study provides evidence of the potential network structure of identity disturbance and so guides clinicians in targeting interventions facilitating personality integration.
Exocomets in the 47 UMa System: Theoretical Simulations Including Water Transport

Motivated by ongoing discoveries of features (most likely) attributable to exocomets in various systems, this study examines the dynamics of possible comets around 47 UMa. Based on the assumption that most systems hosting planets should also harbor leftovers from planet formation processes, comets are thus also expected to exist in the system of 47 UMa. This system is known to host three Jupiter-type planets; however, based on stability analyses, additional terrestrial planets in stable orbits might also be able to exist, including planets in 47 UMa’s habitable zone (HZ). Furthermore, we also consider a possible “Hilda”-planet. The aim of our study is to explore the interaction of exocomets with the Jupiter-type planets in the system and examine the probability of cometary collisions with the planets, including possible Earth-mass planets located in the HZ. Moreover, we investigate the transport of water onto the Earth-mass planets, including quantitative estimates. It is found that most Earth-mass planets would be able to receive some water, but much less than is currently present on Earth. We also checked if the comets form families, but no families were found. Finally, the capture of comets in close orbits and the possibility that small clouds formed when comets come too close to the star and disintegrate are also part of our work.
Bioactive compounds and strategy processing for acerola: A review

Various studies have evaluated that acerola fruit is one of the best natural sources of vitamin- C. Besides that, the fruits also contain a high level of phenolic and carotenoids. The result tested in vitro performed that acerola extract can be antioxidative, anti-inflammatory, antihyperglycemic, antitumor antigenotoxic and hepatoprotective activity. The techniques such as pasteurization, fermentation, extraction, drying, encapsulation can diversify acerola products.
Elementary evaluation of $\int_0^\infty{sin^p t/t^q} dt$

Let $p$ and $q$ be two positive integers, the goal of this note is to demonstrate, in a very simple and elementary way without using advanced tools, a formula to express the value of the integral $I(p,q)=\int_0^\infty{\sin^p t\over t^q}dt$ when it converges.
Optical and near-infrared observations of the GRB020405 afterglow ?

We report on photometric, spectroscopic and polarimetric monitoring of the optical and near-infrared (NIR) afterglow of GRB020405. Ground-based optical observations, performed with 8 different telescopes, started about 1 day after the high-energy prompt event and spanned a period of ∼10 days; the addition of archival HST data extended the coverage up to ∼150 days after the GRB. We report the first detection of the afterglow in NIR bands. The detection of Balmer and oxygen emission lines in the optical spectrum of the host galaxy indicates that the GRB is located at redshift z = 0.691. Fe II and Mg II absorption systems are detected at z = 0.691 and at z = 0.472 in the afterglow optical spectrum. The latter system is likely caused by absorbing clouds in the galaxy complex located ∼2" southwest of the GRB020405 host. Hence, for the first time, the galaxy responsible for an intervening absorption line system in the spectrum of a GRB afterglow is spectroscopically identified. Optical and NIR photometry of the afterglow indicates that, between 1 and 10 days after the GRB, the decay in all bands is consistent with a single power law of index a = 1.54 ′0.06. The late-epoch VLT J-band and HST optical points lie above the extrapolation of this power law, so that a plateau (or "bump") is apparent in the VRIJ light curves at 10-20 days after the GRB. The light curves at epochs later than day ∼20 after the GRB are consistent with a power-law decay with index α' = 1.85 ′ 0.15. While other authors have proposed to reproduce the bump with the template of the supernova (SN) 1998bw, considered the prototypical "hypernova", we suggest that it can also be modeled with a SN having the same temporal profile as the other proposed hypernova SN2002ap, but 1.3 mag brighter at peak, and located at the GRB redshift. Alternatively, a shock re-energization may be responsible for the rebrightening. A single polarimetric R-band measurement shows that the afterglow is polarized, with P = 1.5 ′ 0.4% and polarization angle 0 = 172° ′8°. Broad-band optical-NIR spectral flux distributions show, in the first days after the GRB, a change of slope across the J band which we interpret as due to the presence of the electron cooling frequency v c . The analysis of the multiwavelength spectrum within the standard fireball model suggests that a population of relativistic electrons with index p ∼ 2.7 produces the optical-NIR emission via synchrotron radiation in an adiabatically expanding blastwave, with negligible host galaxy extinction, and the X-rays via Inverse Compton scattering off lower-frequency afterglow photons.
The role of renewable energy sources in residential electricity prices: A club convergence analysis across selected European countries

ABSTRACT This research analyses the convergence of residential electricity prices in 22 European countries between 1995 and 2019. The findings reveal the existence of two sub-convergent clubs of residential electricity prices. Half of the countries studied belong to the club with higher residential electricity prices, while the other half belong to the lower-price club. Household income increases the probability of belonging to the club of lower residential electricity prices. An increase in heating degree days decreases the probability of belonging to the club of lower residential electricity prices. A similar effect is observed for the price of non-renewable energy sources used in electricity production. Further, although a country’s likelihood of belonging to the club of lower residential electricity prices diminishes with a rise in the share of renewable electricity production, the converse pattern is obtained at the residential level, such that residential renewable electricity share has a beneficial effect. Our findings suggest that households have benefitted in paying lower prices for renewable sourced electricity. Therefore, this research indicates that ongoing clean energy initiatives and the availability of affordable substitutes for conventionally generated electricity are being realized to a certain extent, improving electricity markets for the countries we analysed.
Improving the Sensing Properties of Graphene MEMS Pressure Sensor by Low-Temperature Annealing in Atmosphere

The high demand for pressure devices with miniaturization and a wide bearing range has encouraged researchers to explore new high-performance sensors from different approaches. In this study, a sensitive element based on graphene in-plane compression properties for realizing pressure sensing is experimentally prepared using microelectromechanical systems (MEMS) fabrication technology; it consists of a 50 µm thick, 1400 µm wide square multilayer component membrane and a graphene monolayer with a meander pattern. The prepared sample is extensively characterized and analyzed by using various techniques, including atomic force microscopy, Raman spectroscopy, infrared spectroscopy, X-ray photoelectron spectroscopy, COMSOL finite element method, and density functional theory. The sensing performance of the new pressure sensor based on the sensitive element are obtained by theoretical analysis for electromechanical measurements of the sensitive element before and after low-temperature annealing in atmosphere. Results demonstrate that atmospheric annealing at 300 °C enhances the pressure sensing sensitivity by 4 times compared to pristine graphene without annealing, which benefits from the desorption of hydroxyl groups on the graphene surface during annealing. The sensitivity is comparable and even better than that of previous sensors based on graphene in-plane properties. Our results provide new insights into realizing high-performance MEMS devices based on 2D sensitive materials.
The way to the ‘comedy of commons’ of a new business model-finding from Naples in Italy, and Jeju Island in South Korea

ABSTRACT In this study, we seek to examine the success factors of the classical common goods of various capitalist economies and to apply them to diverse platforms that appear as new common goods. Our research question is as follows: Are there any common success factors that can be applied to produce and use common goods across economic conditions? With the goal of identifying the grounded theory of common goods, the study employed the interview method using a semi-structured questionnaire. Furthermore, it conducted participatory observation and a literature review of case studies as well as a comparative study of 20 Korean commons and 20 Italy commons. According to cases of common goods in Jeju, South Korea, the coupling effects of several public policies could motivate the privatization of common goods. Second, an empty area in common goods consists of a high level of participation with democratization and a low level of common condition. High participation with democratization can avoid privatization and increase new open business models of common goods. Third, active open innovation with a high participation in democratization and expansion of new business models based on tacit knowledge of common goods could be the activating engine of regional innovation systems.