Miracle-dz/UniFAR-FTUs huggingface dataset:
ExPUNations: Augmenting Puns with Keywords and Explanations

The tasks of humor understanding and generation are challenging and subjective even for humans, requiring commonsense and real-world knowledge to master. Puns, in particular, add the challenge of fusing that knowledge with the ability to interpret lexical-semantic ambiguity. In this paper, we present the ExPUNations (ExPUN) dataset, in which we augment an existing dataset of puns with detailed crowdsourced annotations of keywords denoting the most distinctive words that make the text funny, pun explanations describing why the text is funny, and fine-grained funniness ratings. This is the first humor dataset with such extensive and fine-grained annotations specifically for puns. Based on these annotations, we propose two tasks: explanation generation to aid with pun classification and keyword-conditioned pun generation, to challenge the current state-of-the-art natural language understanding and generation models’ ability to understand and generate humor. We showcase that the annotated keywords we collect are helpful for generating better novel humorous texts in human evaluation, and that our natural language explanations can be leveraged to improve both the accuracy and robustness of humor classifiers.
JWST Reveals a Possible z ∼ 11 Galaxy Merger in Triply Lensed MACS0647–JD

MACS0647–JD is a triply lensed z ∼ 11 galaxy originally discovered with the Hubble Space Telescope. The three lensed images are magnified by factors of ∼8, 5, and 2 to AB mag 25.1, 25.6, and 26.6 at 3.5 μm. The brightest is over a magnitude brighter than other galaxies recently discovered at similar redshifts z > 10 with JWST. Here, we report new JWST imaging that clearly resolves MACS0647–JD as having two components that are either merging galaxies or stellar complexes within a single galaxy. The brighter larger component “A” is intrinsically very blue (β ∼ −2.6 ± 0.1), likely due to very recent star formation and no dust, and is spatially extended with an effective radius ∼70 ± 24 pc. The smaller component “B” (r ∼ 20 −5+8 pc) appears redder (β ∼ −2 ± 0.2), likely because it is older (100–200 Myr) with mild dust extinction (A V ∼ 0.1 mag). With an estimated stellar mass ratio of roughly 2:1 and physical projected separation ∼400 pc, we may be witnessing a galaxy merger 430 million years after the Big Bang. We identify galaxies with similar colors in a high-redshift simulation, finding their star formation histories to be dissimilar, which is also suggested by the spectral energy distribution fitting, suggesting they formed further apart. We also identify a candidate companion galaxy “C” ∼3 kpc away, likely destined to merge with A and B. Upcoming JWST Near Infrared Spectrograph observations planned for 2023 January will deliver spectroscopic redshifts and more physical properties for these tiny magnified distant galaxies observed in the early universe.
The debate over understanding in AI’s large language models

We survey a current, heated debate in the artificial intelligence (AI) research community on whether large pretrained language models can be said to understand language—and the physical and social situations language encodes—in any humanlike sense. We describe arguments that have been made for and against such understanding and key questions for the broader sciences of intelligence that have arisen in light of these arguments. We contend that an extended science of intelligence can be developed that will provide insight into distinct modes of understanding, their strengths and limitations, and the challenge of integrating diverse forms of cognition.
Polarization in Disks

Polarized dust emission outside of disks reveal the magnetic field morphology of molecular clouds. Within disks, however, polarized dust emission can arise from very different mechanisms (e.g., self-scattering), and each of them are useful for constraining physical properties in the disk. For example, these mechanisms allow us to constrain the disk grain size distributions and grain/disk geometries, independent from current methods of measuring these parameters. To accurately model these features and disentangle the various polarization mechanisms, multiwavelength observations at very high resolution and sensitivity are required. With significant upgrades to current interferometric facilities, we can understand how grains evolve in disks during the planet formation process.
Existence and multiplicity of periodic solutions for some second order Hamiltonian systems

In this paper, we study the existence of nontrivial periodic solutions for the second order Hamiltonian systems ü(t) +∇F(t, u(t)) = 0, where F(t, x) is either nonquadratic or superquadratic as |u| → ∞. Furthermore, if F(t, x) is even in x, we prove the existence of infinitely many periodic solutions for the general Hamiltonian systems ü(t) + A(t)u(t) +∇F(t, u(t)) = 0, where A(·) is a continuous T-periodic symmetric matrix. Our theorems mainly improve the recent result of Tang and Jiang [X.H. Tang, J. Jiang, Existence and multiplicity of periodic solutions for a class of second-order Hamiltonian systems, Comput. Math. Appl. 59 (2010) 3646-3655].
X-ray selection of Compton-Thick AGN at high redshift

Compton-Thick (CT) active galactic nuclei (AGN) are a key ingredient of cosmic X-ray background (CXB) synthesis models, but are still an elusive component of the AGN population beyond the local universe. Multiwavelength surveys are the only way to find them at z > ∼ 0.1, and a deep X-ray coverage is crucial in order to clearly identify them among star-forming galaxies. As an example, the deep and wide COSMOS survey allowed us to select a total of 34 CT sources. This number is computed from the 64 nominal CT candidates, each counted for its NH probability distribution function. For each of these sources, rich multiwavelength information is available, which is used to confirm their obscured nature by comparing the expected AGN luminosity from spectral energy distribution fitting with the absorption-corrected X-ray luminosity. While Chandra is more efficient, for a given exposure, in detecting CT candidates in current surveys (by a factor ∼ 2), deep XMM–Newton pointings of bright sources are vital to fully characterize their properties, for example, NH distribution above 1025 cm− 2, reflection intensity, etc., all crucial parameters of CXB models. Since luminous CT AGN at high redshift are extremely rare, the future of CT studies at high redshift will have to rely on the large-area surveys currently under way, such as XMM-XXL and Stripe82, and will then require dedicated follow-up with XMM–Newton, while waiting for the advent of the ESA mission Athena.
18F‐DCFPyL positron emission tomography/magnetic resonance imaging‐guided ultrasound fusion biopsy is an identical pathway in prostate cancer diagnosis

Prostate biopsy is still unavoidable in patients with a rising prostate‐specific antigen even though multiparametric magnetic resonance imaging (MRI) is widely used. 18F‐DCFPyL positron emission tomography (PET)/MRI was proved to be promising both in sensitivity and specificity. But its guiding fusion biopsy and the advantages in the diagnosis of prostate disease is seldom reported. This study aimed to verify the feasibility and advantage of 18F‐DCFPyL PET/MRI‐guided fusion targeted biopsy (TB) over whole‐mount histopathology (WMH) for prostate cancer diagnosis.
The simultaneous exposure to heat and whole-body vibration on some motor skill functions of city taxi drivers

Background: Driving requires sensory-motor abilities in unpredictable and complex driving scenarios. This experimental study aimed to investigate the combined effects of exposure to whole-body vibration and heat on motor skill functions of city taxi drivers. Methods: This study was conducted using a driving simulator on 30 male taxi drivers. The drivers were exposed to five exposure conditions set by a single or combined exposure of two air temperatures (24 and 30 °C) and two vibration levels (0.5, 1 m/s2). Motor skill functions, including body balance, hand grip strength, and perceived fatigue, were measured using a force plate, dynamometer, and Borg CR-10 questionnaire. Results: The separate exposure to heat did not modify balance and hand grip strength, but its combined exposure to vibration affected balance and grip strength. The effect sizes of heat, vibration, and heat + vibration on balance were respectively 0.003, 0.23, and 0.441. Vibration exposure made the most significant mean differences in hand grip strength compared with the other scenarios. The separate effect of heat on drivers’ perceived fatigue was comparable to vibration. The combined exposure to heat and vibration aggravated the perceived fatigue associated with exposure to heat and vibration alone. Conclusion: Vibration mainly affects the driver’s postural equilibrium, handgrip strength, and fatigue. The heat exposure alone did not have any remarkable effects on the balance responses and handgrip strength; however, it significantly increased the drivers’ perceived fatigue. Exposure to heat can aggravate the effects of vibration on motor skills with a synergistic interaction.
Association of CEA, NSE, CYFRA 21-1, SCC-Ag, and ProGRP with Clinicopathological Characteristics and Chemotherapeutic Outcomes of Lung Cancer.

OBJECTIVE The aim of this study was to investigate the association of serum carcinoembryonic antigen (CEA), nerve-specific enolase (NSE), cytokeratin 19 fragment (CYFRA21-1), squamous cell carcinoma antigen (SCC-Ag), and pro-gastrin-releasing peptide (ProGRP) with the clinicopathological characteristics and chemotherapeutic outcomes of patients with lung cancer. METHODS A total of 189 patients with lung cancer (lung cancer group) diagnosed at the Fourth Affiliated Hospital of Anhui Medical University from January 2020 to December 2021 were included. During the same period, 199 patients with benign lung disorders were included as the benign lung disease group and 75 healthy people were selected as the control group. The serum concentrations of CEA, NSE, CYFRA21-1, SCC-Ag, and ProGRP in all the 3 groups were analyzed and compared in patients with different lung cancer tumor-node-metastasis (TNM) stages and pathological classifications. A total of 11 patients with small cell lung cancer (SCLC) and 18 patients with lung adenocarcinoma (LAC) were further evaluated for the dynamic changes of CEA, NSE, CYFRA21-1, SCC-Ag, and ProGRP before chemotherapy and during the 6 courses of chemotherapy, and the outcome of chemotherapy was evaluated every 2 courses. RESULTS The serum concentrations of CEA, NSE, CYFRA21-1, SCC-Ag, and ProGRP in the lung cancer group were significantly higher than those in the control group (P < .05). We found statistically significant differences in serum CEA, NSE, CYFRA 21-1, SCC-Ag, and ProGRP among patients with different pathological types (LAC, squamous cell carcinoma, or SCLC) and different stages (I-IV). The ProGRP and NSE had the highest expression in SCLC, CEA showed the highest expression in LAC, whereas CYFRA21-1 and SCC-Ag showed the highest expression in lung squamous cell carcinoma (LSCC). The concentrations of all the markers were elevated in the advanced pathological stages. The receiver operating characteristic curve analysis showed that the diagnostic value of the combined detection of CEA, NSE, CYFRA 21-1, SCC-Ag, and ProGRP for lung cancer was significantly higher than using a single biomarker (P < .05). Our dynamic monitoring results show that ProGRP progressively decreased in remission cases of SCLC and CEA progressively decreased in LAC remission cases. CONCLUSION CEA, NSE, CYFRA 21-1, SCC-Ag, and ProGRP have good clinical value in the early diagnosis, differential diagnosis, and progression monitoring of lung cancer. The ProGRP and CEA concentrations are beneficial for evaluating the outcome of chemotherapy in SCLC and LAC. The combined detection of multiple biomarkers shows improved clinical value in the early diagnosis of lung cancer.
Rotationally modulated variations and the mean longitudinal magnetic field of the Herbig Ae star HD 101412

Despite the importance of magnetic fields to a full understanding of the properties of accreting Herbig Ae/Be stars, these fields have scarcely been studied until now over the rotation cycle. One reason for the paucity of these observations is the lack of knowledge of their rotation periods. The sharp-lined young Herbig Ae star HD 101412 with a strong surface magnetic field has become in the past few years one of the most well-studied targets among the Herbig Ae/Be stars. We present our multi-epoch polarimetric spectra of this star acquired with FORS 2 to search for a rotation period and constrain the geometry of the magnetic field. Methods: We measured longitudinal magnetic fields for 13 different epochs distributed over 62 days. These new measurements and our previous measurements of the magnetic field in this star were combined with available photometric observations to determine the rotation period. Results: We find the rotation period to be P = 42.076+/-0.017 d.
A new vertical shock tube for Rayleigh‐Taylor instability measurements

A vertical shock tube built for the study of Rayleigh‐Taylor instability induced turbulent mixing is described. The first results obtained by schlieren visualization concern the interaction between a Mach 1.45 shock wave and subsequent reflected waves and a 1.7 cm wide diffusive SF6‐air mixing zone. The mixing zone behavior is compared to the evolutions obtained in other analogous experiments with the help of a turbulence model in a one‐dimensional code.
Emergence of NDM-1–producing Pseudomonas aeruginosa Sequence Type 773 Clone: Shift of Carbapenemase Molecular Epidemiology and Spread of 16S rRNA Methylase Genes in Korea

Imipenemase (IMP)-6–producing Pseudomonas aeruginosa sequence type (ST) 235 is a dominant clone of carbapenemase-producing P. aeruginosa (CPPAE) in Korea. As part of the Antimicrobial Resistance Surveillance System in Korea, we found an increase in the carbapenem resistance rate of P. aeruginosa isolates from blood cultures and a shift in the molecular epidemiology of CPPAE. A total of 212 non-duplicated P. aeruginosa blood isolates were obtained from nine general hospitals and two nursing homes. Twenty-four isolates were identified as CPPAE. We observed the emergence of the NDM-1 P. aeruginosa ST 773 clone (N=10), mostly from Gyeongsang Province. The IMP-6 ST 235 clone (N=11) was detected in all provinces. CPPAE isolates showed very high resistance rates to amikacin, and all NDM-1 P. aeruginosa strains carried rmtB. This is the first nationwide surveillance of the recently emerged NDM-1–producing P. aeruginosa ST773 clone in Korea. Continuous surveillance is necessary to prevent the infection and transmission of carbapenem- and amikacin-resistant P. aeruginosa in Korea.
Aerobic conditioning alters the satellite cell and ribosome response to acute eccentric contractions in young men and women

Satellite cells (SC) and ribosomes are key determinants of the skeletal muscle adaptive response. Both are thought to increase acutely after resistance exercise and chronically with resistance training. However, the acute SC and ribosome exercise response with prior aerobic conditioning is unknown. Fourteen young men and women underwent 6 weeks of single-legged aerobic conditioning followed by an acute bout of 300 eccentric contractions. Muscle biopsies were taken from the vastus lateralis of the aerobically conditioned (AC) and the control (CTL) legs before (Pre), 24 (24h) and 48 (48h) hours post-contractions. SC pool expansion (PAX7+ cells/100 fibres) was greater in type-I (1.3-fold) and mixed-fibres (1.2-fold) in the AC leg compared to the CTL. Pax7 (1.2-fold) and MyoD1 (1.4-fold) mRNA expression was also greater in the AC leg compared to the CTL. AC had greater RNA concentration (1.2-fold) and mRNA expression of Ubf (1.2-fold) and Tif-1a (1.3-fold) compared to CTL. Only the AC leg increased (Pre-48h) c-Myc (3.0-fold), (Pre-24h) 45S pre-rRNA (2.6-fold), 5.8S ITS (2.1-fold) and 28S ITS (2.0-fold) following eccentric contractions. We discovered that aerobic conditioning augmented type-I SC pool expansion and ribosome content following an acute bout of eccentric contractions.
Optimized transit detection algorithm to search for periodic transits of small planets

We present a new method to detect planetary transits from time-series photometry, the transit least squares (TLS) algorithm. TLS searches for transit-like features while taking the stellar limb darkening and planetary ingress and egress into account. We have optimized TLS for both signal detection efficiency (SDE) of small planets and computational speed. TLS analyses the entire, unbinned phase-folded light curve. We compensated for the higher computational load by (i.) using algorithms such as “Mergesort” (for the trial orbital phases) and by (ii.) restricting the trial transit durations to a smaller range that encompasses all known planets, and using stellar density priors where available. A typical K2 light curve, including 80 d of observations at a cadence of 30 min, can be searched with TLS in ∼10 s real time on a standard laptop computer, as fast as the widely used box least squares (BLS) algorithm. We perform a transit injection-retrieval experiment of Earth-sized planets around sun-like stars using synthetic light curves with 110 ppm white noise per 30 min cadence, corresponding to a photometrically quiet KP = 12 star observed with Kepler. We determine the SDE thresholds for both BLS and TLS to reach a false positive rate of 1% to be SDE = 7 in both cases. The resulting true positive (or recovery) rates are ∼93% for TLS and ∼76% for BLS, implying more reliable detections with TLS. We also test TLS with the K2 light curve of the TRAPPIST-1 system and find six of seven Earth-sized planets using an iterative search for increasingly lower signal detection efficiency, the phase-folded transit of the seventh planet being affected by a stellar flare. TLS is more reliable than BLS in finding any kind of transiting planet but it is particularly suited for the detection of small planets in long time series from Kepler, TESS, and PLATO. We make our python implementation of TLS publicly available.
Postdiagnosis body fatness, weight change and breast cancer prognosis: Global Cancer Update Program (CUP global) systematic literature review and meta‐analysis

Previous evidence on postdiagnosis body fatness and mortality after breast cancer was graded as limited‐suggestive. To evaluate the evidence on body mass index (BMI), waist circumference, waist‐hip‐ratio and weight change in relation to breast cancer prognosis, an updated systematic review was conducted. PubMed and Embase were searched for relevant studies published up to 31 October, 2021. Random‐effects meta‐analyses were conducted to estimate summary relative risks (RRs). The evidence was judged by an independent Expert Panel using pre‐defined grading criteria. One randomized controlled trial and 225 observational studies were reviewed (220 publications). There was strong evidence (likelihood of causality: probable) that higher postdiagnosis BMI was associated with increased all‐cause mortality (64 studies, 32 507 deaths), breast cancer‐specific mortality (39 studies, 14 106 deaths) and second primary breast cancer (11 studies, 5248 events). The respective summary RRs and 95% confidence intervals per 5 kg/m2 BMI were 1.07 (1.05‐1.10), 1.10 (1.06‐1.14) and 1.14 (1.04‐1.26), with high between‐study heterogeneity (I2 = 56%, 60%, 66%), but generally consistent positive associations. Positive associations were also observed for waist circumference, waist‐hip‐ratio and all‐cause and breast cancer‐specific mortality. There was limited‐suggestive evidence that postdiagnosis BMI was associated with higher risk of recurrence, nonbreast cancer deaths and cardiovascular deaths. The evidence for postdiagnosis (unexplained) weight or BMI change and all outcomes was graded as limited‐no conclusion. The RCT showed potential beneficial effect of intentional weight loss on disease‐free‐survival, but more intervention trials and well‐designed observational studies in diverse populations are needed to elucidate the impact of body composition and their changes on breast cancer outcomes.
Randomized Clinical and Biochemical Study Comparing the Effect of L-arginine and Sildenafil in Beta Thalassemia Major Children With High Tricuspid Regurgitant Jet Velocity

Background: Pulmonary hypertension (PHT) is common in β-thalassemia patients due to hemolysis, iron overload and diminished nitric oxide (NO) levels. Biochemical markers can help to understand the pathophysiology and to introduce new therapies for this condition. Aim: This study aimed to evaluate the effectiveness of L-arginine and sildenafil in thalassemia children with PHT at both clinical and biochemical levels. Methods and Results: In a randomized controlled study, 60 β-thalassemia major children with PHT were divided into 3 equal groups; Control group (Conventional thalassemia and PHT management), L-arginine group (Conventional + Oral L-arginine 0.1 mg.kg−1 daily), and sildenafil group (Conventional + Oral sildenafil 0.25 mg.kg−1 two times a day) for 60 days. Tricuspid Regurgitant Jet Velocity (TRJV) with Doppler echocardiography along with serum levels of NO, asymmetric dimethylarginine (ADMA), interleukin 1-beta (IL-1β), E-selectin, and visfatin were followed-up at baseline, 30, and 60 days after treatment. Both drugs reduced the TRJV significantly. NO was significantly higher in both L-arginine and sildenafil groups after 60 days compared to baseline, while visfatin levels were lower. Only L-arginine reduced ADMA levels compared to baseline, while sildenafil did not. E-selectin and IL-1β levels did not change remarkably by both drugs. NO and TRJV showed significant negative correlations in both treatment groups. Conclusion: L-arginine and sildenafil could clinically ameliorate chronic PHT whereas, L-arginine showed superiority to sildenafil on some biochemical markers.
Comparison of incidence and prognosis between young and old gastric cancer patient in North-Western China: A retrospective cohort study

Gastric cancer (GC) is the fourth most common cancer in the world and the second most common cancer in China. In this study, we compared the clinicopathological features and prognosis of GC between young and old patients after curative resection. Six hundred and eighty-six patients with GC resected were divided two groups according to patient age: Younger GC patients ≤40 years of age (YGC, n = 52) and older GC patients >40 years of age (OGC, n = 634). The YGC group had 52 (7.6%) patients in total 686 GC patients. YGC patients was predominant in women (53.8% vs 26.5%) compared with OGC patients. 5-year overall survival exhibited differences in tumor sites, tumor sizes, macroscopic types, T staging, N staging, rate of N staging (rN), tumor node metastasis staging, scope of gastrectomy, radical degree, and lymphatic vascular invasion within each of YGC and OGC group. Univariate analysis of the clinical factors affecting overall survival in YGC group revealed the significant differences in tumor size, macroscopic types (except Borrmann), T staging (except T2), N staging (N3a and N3b), rN, tumor node metastasis staging (III), scope of gastrectomy, radical degree, and lymphatic vascular invasion. Gender, N staging, rN, radical degrees were the independent prognostic factors of younger patients with GC. Similar results were found in the OGC groups. The significant differences in radical degree and lymphatic vascular invasion were found between male and female patients in YGC group. Similar results were found in the OGC groups. Our results showed that YGC patients differ from OGC patients in predominance of women. Gender, N staging, rN, radical degrees were independent risk factors for the prognosis in YGC patients.