Miracle-dz/UniFAR-FTUs huggingface dataset:
Cortisol influences the ontogeny of both-and -subunits of the cardiac sodium channel in fetal sheep

During development, the heart has to adapt to changes in shape, size and, at birth, to significant changes in arterial pressure. The orderly contraction of the heart is dependent on the coordinated expression of ion channels at appropriate densities in individual cardiac myocytes. The present study demonstrated that the expression of the -subunit of the cardiac sodium channel, SCN5a, was high at mid gestation but then decreased until 10 days before birth before increasing again. Whereas the -subunit, SCN1b, gradually increased in expression towards partum, there was no detectable expression of SCN3b at any gestational time point. Fetal adrenalectomy prior to the normal prepartum surge in cortisol caused a reduction in expression of SCN1b and a 7·0 kb transcript of SCN5a, but not the major 8·5 kb transcript. Conversely, cortisol infusion into immature fetuses precociously increased expression levels of SCN1b and the SCN5a 7·0 kb transcript. The results show that cortisol regulates cardiac SCN gene expression in fetal sheep during late gestation. These findings could have implications for the aetiology of sudden infant death syndrome and for the intrauterine programming of adult cardiovascular disease. Journal of Endocrinology (2004) 180, 449–455
The b2-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor*

Many G protein-coupled receptors (GPCRs) activate MAP kinases by stimulating tyrosine kinase signaling cascades. In some systems, GPCRs stimulate tyrosine phosphorylation by inducing the “transactivation” of a receptor tyrosine kinase (RTK). The mechanisms underlying GPCR-induced RTK transactivation have not been clearly defined. Here we report that GPCR activation mimics growth factor-mediated stimulation of the epidermal growth factor receptor (EGFR) with respect to many facets of RTK function. b2-Adrenergic receptor (b2AR) stimulation of COS-7 cells induces EGFR dimerization, tyrosine autophosphorylation, and EGFR internalization. Coincident with EGFR transactivation, isoproterenol exposure induces the formation of a multireceptor complex containing both the b2AR and the “transactivated” EGFR. b2AR-mediated EGFR phosphorylation and subsequent b2AR stimulation of extracellular signal-regulated kinase (ERK) 1/2 are sensitive to selective inhibitors of both EGFR and Src kinases, indicating that both kinases are required for EGFR transactivation. b2AR-dependent signaling to ERK1/2, like direct EGF stimulation of ERK1/2 activity, is sensitive to inhibitors of clathrin-mediated endocytosis, suggesting that signaling downstream of both the EGF-activated and the GPCR-transactivated EGFRs requires a productive engagement of the complex with the cellular endocytic machinery. Thus, RTK transactivation is revealed to be a process involving both association of receptors of distinct classes and the interaction of the transactivated RTK with the cells endocytic machinery.
Desiring Fakes AI, Avatars, and the Body of Fake Information in Digital Art

On 3 November 1948, the Chicago Tribune led with the premature headline “Dewey Defeats Truman”. Thomas E. Dewey was expected to win the presidential election. Instead, the actual winner Harry S. Truman ironically held up a copy of the newspaper after his victory was announced (fig. 1). This historical false report reached unimaginable relevance in 2016: According to most polls of the 45th US presidential election, Hillary Clinton would surely become the next president. Donald J. Trump s̓ shock victory was also attributed to widespread posting and sharing of so-called ‘fake news’ via social media. In light of this, even Facebook felt compelled to make a statement.1 The political dimension of fake news says a lot about forgeries in general: forgeries are not copies. Perpetrators of forgery fake evidence, obscure their sources and rewrite history. Famous art forgers in the 20th century — such as Tom Keating, Eric Hebborn and Edgar Mrugalla — have not copied pictures to compete with the originals, but to imitate the ‘style’ of other artists. What these painters falsified were not objects, but (art) history itself. In this essay I will propose an understanding of forgeries much more as a formal process in the terms of information theory, rather than focusing on the process of their manifestation. In most instances, the word “forgery” is used with negative connotations. However, forgers have often completed (art) history more than actual experts, who, in a way, have written this history with gaps: Forgers have created the missing pieces of the historical puzzle, even if they are false ones. In this context, the German art critic Niklas Maak writes about the spectacular case of the forger Wolfgang Beltracchi:
Clinical Review: Clinical Arrhythmias

Access at: www.AERjournal. com Ventricular arrhythmias remain a major contributor to cardiac morbidity and mortality worldwide, despite ongoing research and implementation of novel therapeutic interventions. Modern management of patients with ventricular arrhythmias requires a multidisciplinary team approach, especially in complex presentations with a background of multiple medical comorbidities. Such teams may include cardiac electrophysiologists (EP), heart failure specialists, general cardiologists and cardiac surgeons, as well as nurses, psychologists and primary care physicians. In emergency presentations with sustained or recurrent ventricular tachycardia (VT) or multiple ICD shocks (‘VT storm’), additional involvement of emergency physicians, intensivists, cardiac anaesthetists and coronary care unit (CCU) staff may be required.
Universality for the Focusing Nonlinear Schrödinger Equation at the Gradient Catastrophe Point: Rational Breathers and Poles of the Tritronquée Solution to Painlevé I

The semiclassical (zero‐dispersion) limit of solutions $q=q(x,t,\epsilon)$ to the one‐dimensional focusing nonlinear Schrödinger equation (NLS) is studied in a scaling neighborhood D of a point of gradient catastrophe ($x_0,t_0$). We consider a class of solutions, specified in the text, that decay as $|x| \rightarrow \infty$. The neighborhood D contains the region of modulated plane wave (with rapid phase oscillations), as well as the region of fast‐amplitude oscillations (spikes). In this paper we establish the following universal behaviors of the NLS solutions q near the point of gradient catastrophe: (i) each spike has height $3|q{_0}(x_0,t_0)|$ and uniform shape of the rational breather solution to the NLS, scaled to the size ${\cal O}(\epsilon)$; (ii) the location of the spikes is determined by the poles of the tritronquée solution of the Painlevé I (P1) equation through an explicit map between D and a region of the Painlevé independent variable; (iii) if $(x,t)\in D$ but lies away from the spikes, the asymptotics of the NLS solution $q(x,t, \epsilon)$ is given by the plane wave approximation $q_0(x,t, \epsilon)$, with the correction term being expressed in terms of the tritronquée solution of P1. The relation with the conjecture of Dubrovin, Grava, and Klein about the behavior of solutions to the focusing NLS near a point of gradient catastrophe is discussed. We conjecture that the P1 hierarchy occurs at higher degenerate catastrophe points and that the amplitudes of the spikes are odd multiples of the amplitude at the corresponding catastrophe point. Our technique is based on the nonlinear steepest‐descent method for matrix Riemann‐Hilbert problems and discrete Schlesinger isomonodromic transformations. © 2013 Wiley Periodicals, Inc.
Fundamentals in the design and scaling of biodigesters with mixing by hydraulic recirculation of wastewater for biogas production using dimensional analysis

In the present work, fundamental relationships and criteria were established for the characterization and scaling of biogas production using a biodigester operated with mixing by hydraulic recirculation of wastewater. A biodigester with a cylindricalconical combined geometry was selected and, using the scale factor and biodigester dimensional relationships, equations were developed for its geometrically scaling, building a program in Simulink (Matlab® software) denominated biodigester.slx. Seventeen process variables were identified and were correlated through dimensional analysis according to the π theorem of Vaschy-Buckingham, to generate the dimensionless numbers of Geometry, Reynolds, Power, Recirculation, and Damköhler I. The dimensionless functions and dimensionless numbers allowed the development of expressions for power consumption and the biogas production volumetric rate from the recirculation velocity and hydraulic recirculation rate, respectively. The above was carried out considering the following three aspects: the behavior of the wastewater as a non-Newtonian fluid, the sludge and manure concentration, and the mixing effect by hydraulic recirculation of the wastewater. Furthermore, from the geometric, kinematic, dynamic, and chemical similitude principles, criteria and equations were established for scaling of recirculation velocity, power consumption, and biogas production volumetric rate. The work is a platform to study biogas production by anaerobic digestion in biodigesters operated by batch, with mixing by hydraulic recirculation of wastewater.
Biological control of adult populations of phylloxera gallicola with enthomopathogenic fungus

In order to analyze the efficacy of the 4 types of fungus preparation based on the Beauveria bassiana spores on the adult populations of phylloxera gallicola an experiment arranged in a randomized complete block design with three replications was organized in the greenhouse conditions. There were taken into study two grapevine varieties, Cabernet Sauvignon and Feteasca alba.The conidia of Beauveria bassiana persisted on the leaves surface and infected the larvae and adults of phylloxera for a period of minimum six days, depending of the bioinsecticide composition. The chemical insecticides caused a stronger and faster lethality in comparison with the fungal biopreparations, the high larval mortality of 90.7% being recorded during the first two days from the treatment. After six days, the rate of lethality caused by the variant of bioinsecticide represented by conidial suspension added with 1% glycerol and 1% canola oil was similar to that produced by chemical preparation. Repeated application of the bioinsecticides based on the Beauveria bassiana can cause a significant reduction of the phylloxera population and it could replace the chemical treatment.
Pseudocompact paratopological groups

We obtain many results and solve some problems about pseudocompact paratopological groups. In particular, we obtain necessary and sufficient conditions when such a group is topological. (2-)pseudocompact paratopological groups that are not topological are constructed. It is proved that each 2-pseudocompact paratopological group is pseudocompact and that each Hausdorff \sigma-compact pseudocompact paratopological group is a compact topological group. Our particular attention is devoted to periodic and topologically periodic groups. In addition, we prove that the product of a nonempty family of pseudocompact paratopological groups is pseudocompact. We show that a paratopological group G is pseudocompact provided it has a normal subgroup N such that both N and the quotient paratopological group G/N are pseudocompact.
Cylindrical Contact Homology on Complements of Reeb Orbits

Let $V$ be a closed 3-manifold with a contact form $\lambda$, and let $L$ be a link consisting of closed orbits for the Reeb vector field of $\lambda$. We study the problem of defining cylindrical contact homology on the non-compact manifold $V \backslash L$, giving sufficient conditions on a class of forms so that the chain complex can be defined in the expected way. Under further technical assumptions we show that the homology of the complex up to isomorphism is independent of choices except possibly the values of certain Conley-Zehnder indices associated with $L$. A simple example shows that the homology can depend on the Conley-Zehnder indices of the components of $L$.
Model Focusing on Gamcheon Culture Village

Gamcheon Culture Village, a well-known tourist area that was regenerated as part of an urban village regeneration initiative, is located in Busan, South Korea. In recent times, the village has received increasing attention as a regional tourism-based regeneration model. However, it is now losing its uniqueness, as a number of similar domestic and international models have mimicked its design due to its success. In addition, as a result of a drastic increase in tourists, problems are arising, such as environmental issues and inconvenience for residents. This study attempts to propose a policy for the sustainable vitalization of Gamcheon Culture Village as a tourist destination based on the application of a co-creation-based regional innovation model, as suggested by Hong et al. (2017). For this purpose, we co-hosted a regional innovation workshop in conjunction with the residents’ committee of Gamcheon Culture Village. According to the analysis results, the main obstacles identified in terms of vitalization were as follows: lack of differentiated tangible and intangible content and service; lack of tourist information; traffic problems; and other inconveniences arising from the coexistence of a tourist location and a residential area. A number of solutions were proposed to these problems, including the development of IT-based content and information; the introduction of products and services highlighting the unique color of the region; improvements to the environment; and the development of policy for the residents. This study has contributed, in that it has applied a co-creation-based regional innovation model to the Gamcheon Culture Village for the first time, and it also offers a guideline for solving problems and drafting realistic policy data.
Riemannian groupoids and solitons for three-dimensional homogeneous Ricci and cross curvature flows

In this paper we investigate the behavior of three-dimensional homogeneous solutions of the cross curvature flow using Riemannian groupoids. The Riemannian groupoid technique, introduced by John Lott, allows us to investigate the long term behavior of collapsing solutions of the flow, producing soliton solutions in the limit. We also review Lott's results on the long term behavior of three-dimensional homogeneous solutions of Ricci flow, demonstrating the coordinates we choose and reviewing the groupoid technique. We find cross curvature soliton metrics on Sol and Nil, and show that the cross curvature flow of SL(2,R) limits to Sol.
Population genetics of cultivated common buckwheat, Fagopyrum esculeutum Moench. II. Frequency of dwarf mutants in Japanese populations')

Allelism tests among 15 independently established dwarf lines revealed that five loci are involved in dwarfism in common buckwheat. They are designated dwA, dwB, dwC, dwD and dwE. The frequencies of dwarf mutants at four loci, dwA, dwB, dwC and dwD were investigated in three Japanese populations, Iwate, Togakushi, Higashi-Iyayama, by using four representative homozygous lines as the testers. The frequencies varied slightly among the populations, but on the average they were 0.235%, 0.067%, 0.294% and 0.196% for the dwA, dwB, dwC and dwD loci, respectively. These low allele frequencies imply that the recurrent mutation is balanced by selection against the dwarf alleles. This conclusion was confirmed by supplemental data on the frequency of dwarf mutants per gamete and a field survey of dwarf homozygotes in randomly mating populations in farmer's field. Approximately 0.50% of the gametes contain a dwarf allele, whereas the incidence of dwarfism in the randomly mating populations was only 4.25 X 10-6. The latter estimate was based on a study of more than 3 million plants.
Plasma Membrane Ca-ATPase Isoforms 2b and 4b Interact Promiscuously and Selectively with Members of the Membrane-associated Guanylate Kinase Family of PDZ (PSD95/Dlg/ZO-1) Domain-containing Proteins*

Spatial and temporal regulation of intracellular Ca signaling depends on localized Ca microdomains containing the requisite molecular components for Ca influx, efflux, and signal transmission. Plasma membrane Ca-ATPase (PMCA) isoforms of the “b” splice type contain predicted PDZ (PSD95/Dlg/ZO-1) interaction domains. The COOH-terminal tail of PMCA2b isolated the membrane-associated guanylate kinase (MAGUK) protein SAP97/hDlg as a binding partner in a yeast two-hybrid screen. The related MAGUKs SAP90/ PSD95, PSD93/chapsyn-110, SAP97, and SAP102 all bound to the COOH-terminal tail of PMCA4b, whereas only the first three bound to the tail of PMCA2b. Coimmunoprecipitations confirmed the interaction selectivity between PMCA4b and SAP102 as opposed to the promiscuity of PMCA2b and 4b in interacting with other SAPs. Confocal immunofluorescence microscopy revealed the exclusive presence and colocalization of PMCA4b and SAP97 in the basolateral membrane of polarized Madin-Darby canine kidney epithelial cells. In hippocampal neurons, PMCA2b was abundant throughout the somatodendritic compartment and often extended into the neck and head of individual spines where it colocalized with SAP90/PSD95. These data show that PMCA “b” splice forms interact promiscuously but also with specificity with different members of the PSD95 family of SAPs. PMCA-SAP interactions may play a role in the recruitment and maintenance of the PMCA at specific membrane domains involved in local Ca regulation.
Simultaneously Non-dense Orbits Under Different Expanding Maps

X iv :0 90 4. 43 65 v1 [ m at h. D S] 2 8 A pr 2 00 9 Simultaneously Non-dense Orbits Under Di erent Expanding Maps David Färm Centre for Mathemati al S ien es Lund University, Sweden david maths.lth. se April 28, 2009 Abstra t Given a point and an expanding map on the unit interval, we onsider the set of points for whi h the forward orbit under this map is bounded away from the given point. For maps like multipli ation by an integer modulo 1, su h sets have full Hausdor dimension. We prove that su h sets have a large interse tion property, i.e. that ountable interse tions of su h sets also have full Hausdor dimension. This result applies to maps like multipli ation by integers modulo 1, but also to nonlinear maps like x 7→ 1/x modulo 1. We prove that the same thing holds for multipli ation modulo 1 by a dense set of non-integer numbers between 1 and 2. 1 Introdu tion 1.1 Multipli ation by integers modulo 1 It is well-know that for maps like fb : [0, 1) → [0, 1) where f : x 7→ bx mod 1 and b is an integer larger than one, the forward orbit (f(x))n=0 is dense for almost all points with respe t to the Lebesgue measure. It follows that sets like Gfb(x) := { y ∈ [0, 1) : x / ∈ ∪n=0f n b (y) } , where x ∈ [0, 1], have zero measure. On the other hand, it is not di ult to see that su h sets have full Hausdor dimension. In this paper we will onsider what happens if we start interse ting su h sets. For example we will prove a theorem that implies dimH(Gf2(x) ∩ Gf3(x)) = 1 and even dimH ( ∞ ⋂
Simulation Based Behavior for a Welfare Robot

Learning the appropriate parameters which lead to a successful action, even under the eﬀect of noise and inaccuracies stemming from faulty perception or poor sensor calibration is of great importance in service robotics, where the ﬂexibility of the robotic systems is a main requirement. This paper proposes a method inspired by available industrial robotics solutions which makes use of a dynamic simulator and Kernel Density Estimation to ﬁnd the parameter sets that lead to a successful Peg-in-Hole action. The obtained solution is successfully tested on a real service robot, where the action is used in the context of picking-up and inserting bottles in a crate for depositing.
Six Sigma and Lean for Enhanced Process Value Chain

Purpose This research highlight the different aspects of implementing lean and six-sigma approach, their contrasting features and integration in manufacturing organizations. Methodology Qualitative research method has been used to conduct this research as the defined period of time for the research was limited. This method was pertinent for the deep analysis of literature and case studies of concerned approaches. It helped to conduct the research in a subjective manner. The use of secondary data saved time from preparing the questionnaires or surveys also the ethical approval to conduct research was not required. Descriptive feature of qualitative research was germane to gather substantial information of related topic from different legitimate resources. For the collected data analysis, Deductive scientific approach has been applied. This research does not make use of any statistical tools for data analysis. Findings Literature studies reveal that Lean Six Sigma has been most frequently used in service organization in comparison of manufacturing industries. It has been observed that the Implementation of Lean Six Sigma gave an amalgam of advantages of both approaches when deployed together in terms of cutting down the cost of production, decreasing process variations, lower process waste and effective resource management. Value These findings shall be helpful for the practitioners who plan to implement LSS in manufacturing organizations. Limitations This research was limited by few factors as the time-frame was not enough to cover up every aspect of the selected topic. Moreover, six case studies were found not to be enough to generalize the model for Lean Six Sigma implementation because there is a possibility of a manufacturing organization of different nature that may not be covered in the research. Furthermore, the concluded concepts shall be applicable only for manufacturing organizations. Adding to this, the research methodology was not enough to add up to the data collection skills of the researcher. Future Research For future studies there is a need to fill the research gap by using quantitative research method to analyze the impact of Lean and Six Sigma integration on process value chain. Future researchers can also take up the service organizations as a subject matter for an extensive research.
Fleming-Viot Processes in an Environment

We consider a new type of lookdown processes where spatial motion of each individual is influenced by an individual noise and a common noise, which could be regarded as an environment. Then a class of probability measure-valued processes on real line $\mbb{R}$ are constructed. The sample path properties are investigated: the values of this new type process are either purely atomic measures or absolutely continuous measures according to the existence of individual noise. When the process is absolutely continuous with respect to Lebesgue measure, we derive a new stochastic partial differential equation for the density process. At last we show that such processes also arise from normalizing a class of measure-valued branching diffusions in a Brownian medium as the classical result that Dawson-Watanabe superprocesses, conditioned to have total mass one, are Fleming-Viot superprocesses.
A counterexample of the birational Torelli problem via Fourier–Mukai transforms

We study the Fourier--Mukai numbers of rational elliptic surfaces. As its application, we give an example of a pair of minimal 3-folds with Kodaira dimensions 1, $h^1(\mc O)=h^2(\mc O)=0$ such that they are mutually derived equivalent, deformation equivalent, but not birationally equivalent. It also supplies a counterexample of the birational Torelli problem.