Miracle-dz/UniFAR-FTUs huggingface dataset:
Tollbooth Automation Using Smartcard Data

Tollbooth automation using smartcard data (RFID tag) echoes the technology which has strong aspects in minimizing the huge overhead as well as the inconvenience in proper collection of toll at tollgates. RFID technology is used to overcome the major issues of time consumption and vehicle congestion. By using this system, there is no need of manual transaction. A vehicle will hold an RFID tag which houses a unique Tag id (identification number). Whenever the vehicle passes the tollgate, the RFID reader mounted at the tollbooth will read the tag and automatically respective amount will be deducted from user’s account. The user comes to know about the transaction by mobile notification. So the toll transaction becomes easier.
Expression of chronic myeloid leukemia oncogenes BCR-ABL P210 and BCR-ABL T315I affect cellular and humoral innate immunity in Drosophila melanogaster

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm that results from a chromosomal translocation between chromosome 9 and chromosome 22. The resulting fusion gene ( BCR-ABL ) encodes a constitutively active BCR-ABL tyrosine kinase. Some mutations of this oncogene, especially the Threonine 315 to Isoleucine substitution of the ABL kinase is resistant to first and second-generation tyrosine kinase inhibitors (TKIs) conventionally used in CML therapy. We have previously validated a CML fruit fly model for drug screening using the adult fly compound eye. Here we expressed wild-type BCR-ABL P210 and mutated BCR-ABL T315I in Drosophila melanogaster hematopoietic system to understand the phenotypic consequences of this expression and its impact on innate immune pathways. Flies expressing both wild-type BCR-ABL P210 and mutant BCR-ABL T315I showed increased number of circulating hemocytes, disruption in sessile patterning of resident hemocytes, dysregulation in the humoral Toll, ImD, and JAK/STAT pathways at the mRNA level in both the 3 rd instar larva and adult stages. Of note, BCR-ABL T315I flies presented more severe phenotypes and a higher deviation in humoral dysregulation than BCR -ABL P210 flies pointing towards more complex oncogenic effect of this mutant which requires further investigation.
Retinal biomarkers of Cerebral Small Vessel Disease: A systematic review

Introduction Cerebral Small Vessel Disease (CSVD), a progressive degenerative disorder of small caliber cerebral vessels, represents a major contributor to stroke and vascular dementia incidence worldwide. We sought to conduct a systematic review of the role of retinal biomarkers in diagnosis and characterization of CSVD. Methods We conducted a systematic review of MEDLINE, PubMed, Scopus, the Cochrane Library Database, and Web of Science. We identified studies of sporadic CSVD (including CSVD not otherwise specified, Cerebral Amyloid Angiopathy, and Hypertensive Arteriopathy) and the most common familial CSVD disorders (including CADASIL, Fabry disease, and MELAS). Included studies used one or more of the following tools: visual fields assessment, fundus photography, Optical Coherence Tomography and OCT Angiography, Fluorescein Angiography, Electroretinography, and Visual Evoked Potentials. Results We identified 48 studies of retinal biomarkers in CSVD, including 9147 cases and 12276 controls. Abnormalities in retinal vessel diameter (11 reports, n = 11391 participants), increased retinal vessel tortuosity (11 reports, n = 617 participants), decreased vessel fractal dimension (5 reports, n = 1597 participants) and decreased retinal nerve fiber layer thickness (5 reports, n = 4509 participants) were the biomarkers most frequently associated with CSVD. We identified no reports conducting longitudinal retinal evaluations of CSVD, or systematically evaluating diagnostic performance. Conclusion Multiple retinal biomarkers were associated with CSVD or its validated neuroimaging biomarkers. However, existing evidence is limited by several shortcomings, chiefly small sample size and unstandardized approaches to both biomarkers’ capture and CSVD characterization. Additional larger studies will be required to definitively determine whether retinal biomarkers could be successfully incorporated in future research efforts and clinical practice.
Two-way text message interventions and healthcare outcomes in Africa: Systematic review of randomized trials with meta-analyses on appointment attendance and medicine adherence

Background The growing access to mobile phones in Africa has led to an increase in mobile health interventions, including an increasing number of two-way text message interventions. However, their effect on healthcare outcomes in an African context is uncertain. This systematic review aims to landscape randomized trials involving two-way text message interventions and estimate their effect on healthcare outcomes. Methods We searched Medline, Embase, Cochrane Central Register of Controlled Trials, The Global Health Library (up to 12 August 2021) and trial registries (up to 24 April 2020). Published and unpublished trials conducted in Africa comparing two-way text message interventions with standard care and/or one-way text message interventions were included. Trials that reported dichotomous effect estimates on healthcare appointment attendance and/or medicine adherence were assessed for risk of bias and included in meta-analyses. Results of other outcomes were reported descriptively. Results We included 31 trials (28,563 participants) all set in Sub-Saharan Africa with a wide range of clinical conditions. Overall, ten different trials were included in the primary meta-analyses, and two of these had data on both medicine adherence and appointment attendance. An additional two trials were included in sensitivity analyses. Of the 12 included trials, three were judged as overall low risk of bias and nine as overall high risk of bias trials. Two-way text messages did not improve appointment attendance, RR: 1.03; 95% CI: 0.95–1.12, I2 = 53% (5 trials, 4374 participants) but improved medicine adherence compared to standard care, RR: 1.14, 95% CI: 1.07–1.21, I2 = 8% (6 trials, 2783 participants). Conclusion Two-way text messages seemingly improve medicine adherence but has an uncertain effect on appointment attendance compared to standard care. Systematic review registration PROSPERO CRD42020175810.
DAO-CP: Data-Adaptive Online CP decomposition for tensor stream

How can we accurately and efficiently decompose a tensor stream? Tensor decomposition is a crucial task in a wide range of applications and plays a significant role in latent feature extraction and estimation of unobserved entries of data. The problem of efficiently decomposing tensor streams has been of great interest because many real-world data dynamically change over time. However, existing methods for dynamic tensor decomposition sacrifice the accuracy too much, which limits their usages in practice. Moreover, the accuracy loss becomes even more serious when the tensor stream has an inconsistent temporal pattern since the current methods cannot adapt quickly to a sudden change in data. In this paper, we propose DAO-CP, an accurate and efficient online CP decomposition method which adapts to data changes. DAO-CP tracks local error norms of the tensor streams, detecting a change point of the error norms. It then chooses the best strategy depending on the degree of changes to balance the trade-off between speed and accuracy. Specifically, DAO-CP decides whether to (1) reuse the previous factor matrices for the fast running time or (2) discard them and restart the decomposition to increase the accuracy. Experimental results show that DAO-CP achieves the state-of-the-art accuracy without noticeable loss of speed compared to existing methods.
The Initial State of Pedestrian in Accident Reconstruction

In order to improve the reality of pedestrian traffic accident reconstruction,pre-impact initial state of pedestrian was researched and the simulation method of walking dummy was presented.Based on this method,the dynamic response of walking human was modeled using multi-body dynamics method and used as the initial simulation condition for accident reconstruction.In a real-world accident case,several methods of determining pre-impact state of pedestrian were used to simulate the collision between pedestrian and bus.The influence of pedestrian's pre-impact state was analyzed in terms of the results of different methods.
Research on Nonlinear Ultrasonic Properties of Tension Stress in Metal Materials

： Assuming small strain condition, perturbation method is used to resolve one dimensional wave equation. The nonlinear wave rule is studied when ultrasonic wave propagates in solid medium. When tension stresses change in metal materials, the variation trends of the nonlinear coefficients β and δ are studied. The nonlinear ultrasonic testing system is set up to detect the harmonic wave amplitudes. The variation trends of the nonlinear coefficients with stresses are acquired. The results show that the nonlinear coefficients increase with the tension stress. For 2024 aluminum alloy, the second order nonlinear coefficient β is approximately linear with the tension stress when the tension stress is smaller than 84.6% of the yield strength, and it increases slowly with tension stress when the tension stress is bigger than 84.6% of the yield strength. For 45 steel, the second order nonlinear coefficient β increases linearly with the stress when the tress is smaller than 84.5% of strength stress, and it increases quickly with stress when the stress is bigger than 84.5% of the yield strength. The third nonlinear coefficients δ have change points in 76.9% and 78.9% of yield strength for 2024 aluminum alloy and 45 steel, respectively. The second nonlinear coefficients β and the third nonlinear coefficients have different sensitivities to the stress. The third nonlinear coefficients δ have higher sensitivity than the second nonlinear coefficients β .
Interfacial Polymetallic Oxides and Hierarchical Porous Core-Shell Fibres for High Energy-Density Electrochemical Supercapacitors.

Realizing high energy-density and actual applications of fibre-based electrochemical supercapacitors (FESCs) are pivotal but challenging, as the ability to architect advanced fibres for accelerating charges kinetic diffusion and faradic storage remains key bottlenecks. Here, we demonstrate high-performance FESCs based on hetero-structured polymetallic oxides/porous graphene core-sheath fibres, where the large pseudo-active polymetallic oxides (PMO) sheath is uniformly loaded on hierarchical porous graphene fibre (PGF) core. Due to the abundant micro-/mesoporous pathways, large accessible surface, excellent redox activity and good interface electron conduction, the PMO-PGF possesses high areal capacitance (2959.78 mF cm-2) and manageable faradic reversibility in 6 M KOH electrolyte. Furthermore, the PMO-PGF-based solid-state FESCs present high energy-density (187.22 μWh cm-2), long-life cycles (95.8% capacitive retention after 20000 cycles), diverse-powered capabilities and actual energy-supply applications.
Advances in Mid-IR Fiber Lasers: Tellurite, Fluoride and Chalcogenide

A review on the recent progress in modeling and fabrication of medium infrared (Mid-IR) fiber lasers is reported. The main objective is to illustrate some recent examples of continuous wave optical sources at wavelengths longer than those commonly employed in telecom applications and allowing high beam quality. A small number of Mid-IR lasers, among the large variety of schemes, glasses, dopants and pumping schemes reported in literature, is selected on the basis of their slope efficiency and threshold pump power. In particular, tellurite, fluoride and chalcogenide fiber lasers are considered. More details are given with reference to the novel pumping schemes.
Comprehensive treatment of pelvic floor muscle training plus biofeedback electrical stimulation for stress urinary incontinence: a clinical study.

OBJECTIVE To investigate the clinical effect of pelvic floor muscle training (PFMT) plus biofeedback electrical stimulation (BES) on stress urinary incontinence (SUI). METHODS 110 patients with SUI admitted to our hospital in the Department of Obstetrics and Gynecology from November 2018 to November 2019 were selected and divided into control group (n=55) and study group (n=55). The study group received PFMT plus BES while the control group received PFMT alone. RESULTS Compared with the control group, the incontinence quality of life (I-QOL) score and the international consultation on incontinence questionnaire-urinary incontinence short form (ICI-Q-SF) score in the study group were significantly better (P<0.05), and the patients had better pelvic floor muscle endurance, strength, and coordination (P<0.05). CONCLUSION PFMT plus BES could improve the strength, endurance, and coordination of pelvic floor muscles in SUI patients. It can positively influence the improvement of the I-QOL and ICI-Q-SF scores. CLINICAL TRIAL REGISTRATION The name of the registry: Chinese Registry of Clinical Trials. TRIAL REGISTRATION NUMBER ChiCTR21000684765. Trial URL: http://www.chictr. org.cn/showproj.aspx? proj=73654424.
Macrophage Depletion Attenuates Acute Renal Damage after Exhaustive Exercise in Mice

Abstract Exhaustive exercise is known to induce acute renal damage. However, the precise mechanisms remain unclear. We investigated the effects of macrophage depletion on exhaustive exercise-induced acute renal damage. Male C57BL/6 J mice were divided into four groups: sedentary with control liposome (n=8), sedentary with clodronate liposome (n=8), exhaustive exercise with control liposome (n=8), and exhaustive exercise with clodronate liposome (n=8). Mice were treated with clodronate liposomes or control liposomes intraperitoneally for 48 h before undergoing exhaustive exercise. Renal function and renal histology were tested at 24 h. The expression levels of kidney injury molecule (KIM)-1 and inflammatory cytokines in kidney tissues were measured by quantitative RT-PCR, and KIM-1 concentration was semi-quantified by immunostaining. As a result, exhaustive exercise increased macrophage infiltration into the kidney. However, clodronate reduced it. Although exhaustive exercise resulted in an increase in KIM-1 mRNA expression levels and concentration, injection of clodronate liposome reduced it. In addition, TUNEL positive apoptotic cells were increased after exercise, but significantly reduced by clodronate. Clodronate liposome treatment also decreased the mRNA expression levels of inflammatory cytokines (TNF-α, IL-1β, and IL-6) in the kidney after exhaustive exercise. These results suggest that macrophages play a critical role in increasing renal damage by regulating inflammation.
Association between individual wheelchair skills and fitness in community-dwelling manual wheelchair users with spinal cord injuries

Abstract Purpose Wheelchair skills are a key component to promotion of community participation among persons with spinal cord injury (SCI). The objective of this secondary analysis was to examine the association between individual wheelchair skills from the Wheelchair Skills Test Questionnaire (WST-Q) and fitness among community-dwelling adults with SCI. Materials and methods Twenty-six adults were recruited to complete the WST-Q and a standard graded aerobic wheelchair exercise test on a motorized treadmill for assessing peak power output (POpeak). Results Spearman Rho rank-order correlation (ρ) analyses indicated statistically significant correlations between POpeak and six basic (ρ = 0.41–0.57), eight intermediate (ρ = 0.44–0.59), and nine advanced (ρ = 0.42–0.80) WST-Q skill scores. After controlling for sex and injury level (Partial Spearman Rho rank order) significant correlations persisted for four advanced skills (i.e., descends high curb, turns in place in wheelie position, descends steep incline in wheelie position, descends high curb in wheelie position; ρ = 0.46–0.59) and one additional skill (i.e., ascends high curb ρ = 0.51). Conclusions More advanced wheelchair skills are significantly associated with fitness in persons with SCI. The directionality of the skills-fitness relationship, specifically whether wheelchair skills facilitate greater fitness or fitness is a prerequisite for certain wheelchair skills needs to be determined in future, larger studies. However, results from this study provide a comprehensive list of wheelchair skills that are associated with fitness that can be directly applied to guide further research and practice promoting community participation among persons with SCI. Implications for Rehabilitation Significant positive associations exist between advanced wheelchair skills (i.e., descends high curb, turns in place in wheelie position, descends steep incline in wheelie position, descends high curb in wheelie position and ascends high curb) and fitness in manual wheelchair users with spinal cord injury (SCI). This study provides a list of skills associated with fitness to guide clinical practice and areas for further rehabilitation research assessing the directionality of the relationship between fitness and wheelchair skills.
Dynamic analysis of tapered circular discs made of isotropic and orthotropic materials using Rayleigh-Ritz method and ANSYS.

Tapered rotating circular disc provides advantages of preferred stress state compared to the uniform-thickness circular disc rotating at the same speed. Hence, linearly-tapered circular disc and circular disc with hyperbolic profile along radial direction, often known as Stodola’s disc, are increasingly being used in many engineering applications such as in automobiles, turbomachinery, steam turbines, flywheels, and space structures. It is important to study the in-plane dynamics and out-of-plane dynamics of such circular discs as they play a vital role in causing vibration and noise. Design of circular disc for such applications also requires the knowledge of three-dimensional bending vibration characteristics of the disc. The present thesis aims at developing a generalized formulation and then to investigate the three-dimensional in-plane and out-of-plane vibration characteristics of uniform-thickness circular annular disc, linearly-tapered circular annular disc, and Stodola’s disc with clamped-free boundary condition. The trigonometric functions in circumferential coordinate are employed in all the three displacement components in Rayleigh-Ritz method to calculate the natural frequencies. The numerical approach based on Rayleigh-Ritz method with finite-element-like modification has been developed to study the free vibration behaviour of the tapered circular discs made of isotropic and orthotropic materials and of clamped-free boundary condition. Numerical and symbolic computations have been performed using MATLAB and MAPLE software. The results for natural frequencies have been validated using Finite Element Method using ANSYS and results from previous literature wherever available. A comprehensive parametric study is conducted to study the effects of various design parameters.
Monte Carlo evaluation of high-gradient magnetically focused planar proton minibeams in a passive nozzle

Objective. To investigate the potential of using a single quadrupole magnet with a high magnetic field gradient to create planar minibeams suitable for clinical applications of proton minibeam radiation therapy. Approach. We performed Monte Carlo simulations involving single quadrupole Halbach cylinders in a passively scattered nozzle in clinical use for proton therapy. Pencil beams produced by the nozzle of 10–15 mm initial diameters and particle range of ∼10–20 cm in water were focused by magnets with field gradients of 225–350 T m−1 and cylinder lengths of 80–110 mm to produce very narrow elongated (planar) beamlets. The corresponding dose distributions were scored in a water phantom. Composite minibeam dose distributions composed from three beamlets were created by laterally shifting copies of the single beamlet distribution to either side of a central beamlet. Modulated beamlets (with 18–30 mm nominal central SOBP) and corresponding composite dose distributions were created in a similar manner. Collimated minibeams were also compared with beams focused using one magnet/particle range combination. Main results. The focusing magnets produced planar beamlets with minimum lateral FWHM of ∼1.1–1.6 mm. Dose distributions composed from three unmodulated beamlets showed a high degree of proximal spatial fractionation and a homogeneous target dose. Maximal peak-to-valley dose ratios (PVDR) for the unmodulated beams ranged from 32 to 324, and composite modulated beam showed maximal PVDR ranging from 32 to 102 and SOBPs with good target dose coverage. Significance. Advantages of the high-gradient magnets include the ability to focus beams with phase space parameters that reflect beams in operation today, and post-waist particle divergence allowing larger beamlet separations and thus larger PVDR. Our results suggest that high gradient quadrupole magnets could be useful to focus beams of moderate emittance in clinical proton therapy.
Factors Associated with Binge Drinking—Findings from 2019 Kansas Behavioral Risk Factor Surveillance System

Background: In the U.S., excessive drinking accounts for one in 10 deaths among adults aged 20–64 years old. Binge drinking is a common form of excessive alcohol consumption that contributes to this chilling statistic. Binge drinking is defined as women consuming four or more drinks or men consuming five or more drinks within a 2-h time span. Examining existing data on risk factors for binge drinking can inform strategies to prevent this deadly practice. Methods: The 2019 Kansas Behavioral Risk Factor Surveillance System (BRFSS) dataset consists of data collected from 11,368 non-institutionalized adults aged 18 years and older with landline or cell phones. The dependent variable in this study was binge drinking status. The independent variables included several sociodemographic variables and risk factors. Data were analyzed using descriptive statistics, bivariate analysis, single logistic regression, and multivariable logistic regression. Results: In the population, 1,447 (17.4%) were reported to be binge drinkers. Significant factors associated with binge drinking in the final model included sex (aOR = 0.53 (0.45–0.63)), age (18–24 years old aOR = 8.77 (6.02–12.79); 25–34 years old aOR = 7.10 (5.35–9.42); 35–44 years old aOR = 6.23 (4.73–8.19); 45–54 years old aOR = 3.87 (2.92–5.14); and 55–64 years old aOR = 2.58 (1.96–3.38)), income ($15,000–$24,999 aOR = 1.00 (0.63–1.58); $25,000–$34,999 aOR = 1.61 (1.04–2.50); $35,000-$49,999 aOR = 1.69 (1.13–2.55); ≥$50,000 aOR = 1.97 (1.34–2.89)), smokeless tobacco use (aOR = 2.09 (1.55–2.82)), and smoking/e-cigarette use (Cigarette user only aOR = 2.11 (1.69–2.65); E-cigarette user only aOR = 2.67 (1.62–3.17); dual cigarette and e-cigarette user = 3.43 (2.21–5.33)). Conclusion: Developing interventions that take into account elevated risk for binge drinking amongst demographic characteristics (i.e., age, sex, income) and lifestyle factors (i.e., smokeless tobacco use, and smoking/e-cigarette use) is crucial to lowering morbidity and mortality related to this form of excessive alcohol consumption.
Comment on “Impact of neurodegenerative diseases on human adult hippocampal neurogenesis”

Terreros-Roncal et al. investigated the impacts of human neurodegeneration on immunostainings assumed to be associated with neurogenesis. However, the study provides no evidence that putative proliferating cells are linked to neurogenesis, that multipolar nestin+ astrocytes are progenitors, or that mature-looking doublecortin+ neurons are adult-born. Their histology-marker expression differs from what is observed in species where adult hippocampal neurogenesis is well documented.