Miracle-dz/UniFAR-FTUs huggingface dataset:
Enhancing Psychological Counseling with Large Language Model: A Multifaceted Decision-Support System for Non-Professionals

In the contemporary landscape of social media, an alarming number of users express negative emotions, some of which manifest as strong suicidal intentions. This situation underscores a profound need for trained psychological counselors who can enact effective mental interventions. However, the development of these professionals is often an imperative but time-consuming task. Consequently, the mobilization of non-professionals or volunteers in this capacity emerges as a pressing concern. Leveraging the capabilities of artificial intelligence, and in particular, the recent advances in large language models, offers a viable solution to this challenge. This paper introduces a novel model constructed on the foundation of large language models to fully assist non-professionals in providing psychological interventions on online user discourses. This framework makes it plausible to harness the power of non-professional counselors in a meaningful way. A comprehensive study was conducted involving ten professional psychological counselors of varying expertise, evaluating the system across five critical dimensions. The findings affirm that our system is capable of analyzing patients' issues with relative accuracy and proffering professional-level strategies recommendations, thereby enhancing support for non-professionals. This research serves as a compelling validation of the application of large language models in the field of psychology and lays the groundwork for a new paradigm of community-based mental health support.
Gene therapy for adenosine deaminase deficiency

Purpose of reviewGene therapy for severe combined immunodeficiency due to adenosine deaminase deficiency has moved from the early trials of safety and feasibility to recent studies demonstrating efficacy and clinical benefit. This review describes the latest advances in gene therapy trials for this condition using peripheral blood lymphocytes or hematopoietic progenitors. Recent findingsIn the first patients with severe combined immunodeficiency due to adenosine deaminase deficiency treated with peripheral blood lymphocytes, transduced T cells have been shown to persist for over 10 years, expressing transgenic adenosine deaminase, but the therapeutic effect of gene therapy remained difficult to assess because of the concomitant treatment with bovine adenosine deaminase conjugated to polyethylene-glycol (PEG-ADA). A recent report showed that discontinuation of PEG-ADA resulted in a strong selective advantage of gene corrected T cells associated with restoration of T cell functions and antibody responses to neoantigen, but incomplete correction of the metabolic defect. Follow-up studies in patients treated with engineered hematopoietic progenitors in the early trials revealed low marking levels of long-term living progenitors and limited clinical effect. Recently, an improved gene transfer protocol in bone marrow CD34+ cells combined with low-dose busulfan resulted in multilineage, stable engraftment of transduced progenitors at substantial levels, restoration of immune functions, correction of the adenosine deaminase metabolic defect, and proven clinical benefit, in the absence of PEG-ADA. Overall, no adverse effect or toxicity has been observed in patients treated with adenosine deaminase gene transfer in mature lymphocytes or hematopoietic progenitors. SummaryGene transfer in hematopoietic stem cells combined with nonmyeloablative conditioning is efficacious and might be extended to the treatment of other inherited and acquired disorders of the hematopoietic system.
Bearing-based Formation with Disturbance Rejection

This paper considers the problem of the bearing-based formation control with disturbance rejection for a group of agents under the leader-follower structure. The disturbances are in the form of a trigonometric polynomial with arbitrary unknown amplitudes, unknown initial phases, and known or unknown frequencies. For the case of the known frequencies, we employ the canonical internal model to solve the problem, and, for the case of the unknown frequencies, we combine the canonical internal model and {some} distributed adaptive control technique to deal with the problem. It is noted that the existing results can only handle constant input disturbances by continuous control laws or disturbances with known {bounds} by discontinuous control laws. The first case is a special case of our result. The second case cannot cover our results because the bound of our disturbance is unknown. Moreover, our control law is smooth.
DoubleCheck: Designing Community-based Assessability for Historical Person Identification

Historical photos are valuable for their cultural and economic significance, but can be difficult to identify accurately due to various challenges such as low-quality images, lack of corroborating evidence, and limited research resources. Misidentified photos can have significant negative consequences, including lost economic value, incorrect historical records, and the spread of misinformation that can lead to perpetuating conspiracy theories. To accurately assess the credibility of a photo identification (ID), it may be necessary to conduct investigative research, use domain knowledge, and consult experts. In this paper, we introduce DoubleCheck, a quality assessment framework for verifying historical photo IDs on Civil War Photo Sleuth (CWPS), a popular online platform for identifying American Civil War-era photos using facial recognition and crowdsourcing. DoubleCheck focuses on improving CWPS’s user experience and system architecture to display information useful for assessing the quality of historical photo IDs on CWPS. In a mixed-methods evaluation of DoubleCheck, we found that users contributed a wide diversity of sources for photo IDs, which helped facilitate the community’s assessment of these IDs through DoubleCheck’s provenance visualizations. Further, DoubleCheck’s quality assessment badges and visualizations supported users in making accurate assessments of photo IDs, even in cases involving ID conflicts.
AI ATAC 1: An Evaluation of Prominent Commercial Malware Detectors

This work presents an evaluation of six prominent commercial endpoint malware detectors, a network malware detector, and a file-conviction algorithm from a cyber technology vendor. The evaluation was administered as the first of the Artificial I ntelligence Applications t o Autonomous Cybersecurity (AI ATAC) prize challenges, funded by / completed in service of the US Navy. The experiment employed 100K files (50/50% benign/malicious) with a stratified distribution of file types, including ~1K zero-day program executables (increasing experiment size two orders of magnitude over previous work). We present an evaluation process of delivering a file to a fresh virtual machine donning the detection technology, waiting 90s to allow static detection, then executing the file and waiting another period for dynamic detection; this allows greater fidelity in the observational data than previous experiments, in particular, resource and time-to-detection statistics. To execute all 800K trials (100K files × 8 tools), a software framework is designed to choreograph the experiment into an automated, time-synced, and reproducible workflow with substantial parallelization. Software with base classes for this framework are provided. A cost-benefit model was configured to integrate the tools’ detection statistics into a comparable quantity by simulating costs of use. This provides a ranking methodology for cyber competitions and a lens for reasoning about the varied statistical results. The results provide insights on state of commercial malware detection.
Stress tensor bounds on quantum fields

The singular behaviour of quantum fields in Minkowski space can often be bounded by polynomials of the Hamiltonian $H$. These so-called $H$-bounds and related techniques allow us to handle pointwise quantum fields and their operator product expansions in a mathematically rigorous way. A drawback of this approach, however, is that the Hamiltonian is a global rather than a local operator and, moreover, it is not defined in generic curved spacetimes. In order to overcome this drawback we investigate the possibility of replacing $H$ by a component of the stress tensor, essentially an energy density, to obtain analogous bounds. For definiteness we consider a massive, minimally coupled free Hermitean scalar field. Using novel results on distributions of positive type we show that in any globally hyperbolic Lorentzian manifold $M$ for any $f,F\in C_0^{\infty}(M)$ with $F\equiv 1$ on $\mathrm{supp}(f)$ and any timelike smooth vector field $t^{\mu}$ we can find constants $c,C>0$ such that $\omega(\phi(f)^*\phi(f))\le C(\omega(T^{\mathrm{ren}}_{\mu\nu}(t^{\mu}t^{\nu}F^2))+c)$ for all (not necessarily quasi-free) Hadamard states $\omega$. This is essentially a new type of quantum energy inequality that entails a stress tensor bound on the smeared quantum field. In $1+1$ dimensions we also establish a bound on the pointwise quantum field, namely $|\omega(\phi(x))|\le C(\omega(T^{\mathrm{ren}}_{\mu\nu}(t^{\mu}t^{\nu}F^2))+c)$, where $F\equiv 1$ near $x$.
Up-regulation of cKaP2l expression promotes lung adenocarcinoma invasion and is associated with poor prognosis

of to the of cytoskeleton-associated 2-like (CKAP2L) in lung adenocarcinoma (LAD) development and its prognostic value. Methods: The mRNA expression of CKAP2L and its correlation with clinical factors in LAD patients were analyzed from the data taken from The Cancer Genome Atlas and The First Affiliated Hospital of Kunming Medical University. We constructed H460 and A549 cell lines with silenced CKAP2L using RNA interference. Cell counting kit-8 assay and colony formation assays were carried out to determine the function of CKAP2L in H460 and A549 cell proliferation. Transwell and wound healing assays were applied to determine the effect of CKAP2L on H460 and A549 cell invasion and migration. The influences of CKAP2L on mitogen-activated protein kinase signaling pathway-related proteins were tested by Western blotting. Results: CKAP2L expression is enhanced in LAD tissues and is predictive of poor prognosis in LAD patients. High expression of CKAP2L is associated with stage ( P , 0.001), lymph node status ( P = 0.002), and metastasis ( P = 0.025). Depletion of CKAP2L dramatically suppressed the proliferation, migration, and invasion of H460 and A549 cells. Moreover, the ratio of p-MEK/ MEK and p-ERK/ERK reduced obviously in A549 cells after depleting CKAP2L. Conclusion: Our findings implied that CKAP2L might be a promoter of LAD and could serve as a predictor for LAD patients.
a 1-year follow-up study exploring the associations between perception of illness and health-related quality of life in persons with chronic obstructive pulmonary disease

License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress. com/permissions.php International Journal of COPD 2014:9 41–50 International Journal of Chronic Obstructive Pulmonary Disease Dovepress
Design and first results of a survey on healthcare planning policies, strategies and programmes that address mental health promotion and mental disorder prevention for older people in Europe

Zusammenfassung Z Gerontol Geriat DOI 10.1007/s00391-017-1290-7 © Springer Medizin Verlag GmbH 2017 L. Neumann · U. Dapp · W. Jacobsen · F. van Lenthe · W. von Renteln-Kruse TheMINDMAP project: mental well-being in urban environments. Design and first results of a survey on healthcare planning policies, strategies and programmes that address mental health promotion andmental disorder prevention for older people in Europe Abstract Background. The MINDMAP consortium (2016–2019) aims to identify opportunities provided by the urban environment for the promotion of mental well-being and functioning of older people in Europe by bringing together European cities with urban longitudinal ageing studies: GLOBE, HAPIEE, HUNT, LASA, LUCAS, RECORD, Rotterdam Study, Turin Study. A survey on mental healthcare planning policies and programmes dedicated to older persons covering the range from health promotion to need of nursing care was performed for profound data interpretation in Amsterdam, Eindhoven, Hamburg, Helsinki, Kaunas, Krakow, London, Nord-Trøndelag, Paris, Prague, Rotterdam and Turin. Objectives. To collect detailed information on healthcare planning policies and programmes across these European cities to evaluate variations and to delineate recommendations for sciences, policies and planners using experience from evidence-based practice feedback from the MINDMAP cities. Materials and methods. The MINDMAP partners identified experts in the 12 cities with the best background knowledge of the mental health sector. After pretesting, semi-structured telephone interviews (1–2 h) were performed always by the same person. A structured evaluationmatrix based on the geriatric functioning continuum and the World Health Organization (WHO) Public Health Framework for Healthy Ageing was applied. Results. A complete survey (12 out of 12) was performed reporting on 41 policies and 280 programmes on the city level. It appeared from extensive analyses that the focus on older citizens, specific target groups, and multidimensional programmes could be intensified. Conclusion. There is a broad variety to cope with the challenges of ageing in health, and to address both physical and mental capacities in older individuals and their dynamic interactions in urban environments.
Feline gut microbiota composition in association with Feline coronavirus infection: a 4 pilot study

Feline coronaviruses (FCoV) colonize the intestinal tract, however, due to not fully understood 25 mutations, they can spread systemically and cause feline infectious peritonitis (FIP). Recent 26 studies on human medicine report that gut microbiota is involved in the development of 27 systemic disorders and could influence the immune response to viral diseases. The aim of this 28 study was to provide preliminary data on the fecal microbiota composition in healthy cats 29 compared to FCoV-infected cats, with and without FIP. Cats were equally grouped as healthy 30 FCoV-negative, healthy FCoV-positive or FIP affected (total n = 15). Fecal sample were 31 evaluated for the microbiota composition. A total of 3,231,916 sequences were analyzed. The 32 samples’ alpha-diversity curves did not reach a proper plateau and, for the beta-diversity, the 33 samples seemed not to group perfectly by category, even if the healthy FCoV-positive group 34 showed a hybrid microbial composition between FCoV-negative and FIP groups. Although 35 there were no taxa significantly linked to the different conditions, some peculiar patterns were 36 recognized: Firmicutes was the most represented phylum in all the samples, followed by 37 Bacteroidetes and Actinobacteria. In FCoV-positive cats, the Firmicutes and Bacteroidetes 38 were respectively over- and under-represented, compared to the other groups. Among FIP cats, 39 three subjects shared a similar microbiome, one cat showed a different microbial profile and 40 the other one had the lowest number of diverse phyla. Despite the limited number of animals, 41 some differences in the fecal microbiome between the groups were observed, suggesting to 42 further investigate the possible correlation between gut microbiota and FCoV infection in cats.
Reliability and Validity of the LifeWindows Information – Motivation – Behavioral Skills Antiretroviral Therapy Adherence Questionnaire Among HIV+ Patients in Shanghai Patient Preference and Adherence

Objective: The purpose of this article was to examine the validity and reliability of the LifeWindows Information – Motivation – Behavioral Skills Antiretroviral Therapy (ART) Adherence Questionnaire (LW-IMB-AAQ) among HIV+ patients in Shanghai. Methods: We surveyed 426 HIV+ patients in Shanghai ’ s Putuo District to examine the validity and reliability of the questionnaire. The questionnaire includes self-reported demographic characteristics, the modi ﬁ ed version of the Community Programs for Clinical Research on AIDS Antiretroviral Medication Self-Report (CPCRA) and LW-IMB-AAQ. CPCRA was used to calculate ART adherence. LW-IMB-AAQ, including the information section, the motivation section and the behavioral skills section, was used to analyze patients ’ ART adherence. We analyzed data by means, standard deviation, critical ratio, and item-total correlation. Reliability was assessed by internal consistency, split-half reliability, and test – retest reliability. Validity was assessed by exploratory factor analysis (EFA), con ﬁ rmatory factor analysis (CFA), convergent validity and discriminant validity. Results: Item analysis showed that except for motivation item 1, all items were acceptable. For reliability, Cronbach ’ s alpha coef ﬁ cients for the three sections and the total scale were all higher than 0.7, with interclass correlation coef ﬁ cients (ICC) all higher than 0.6 (p<0.001). The Spearman – Brown coef ﬁ cient for the total scale was 0.825. For validity, results showed that the information section could be divided into two subscales, motivation section and behavioral skills section could be divided into three and two subscales, respectively. The ﬁ nal model demonstrated good validity (p=0.471, χ 2 /df=0.960, CFI=1.000, GFI=0.994 and RMSEA<0.001) without motivation item 4. Conclusion: Excluding motivation items 1 and 4, the LifeWindows Information – Motivation – Behavioral Skills ART Adherence Questionnaire (LW-IMB-AAQ) demonstrated good validity and reliability among HIV+ patients in Shanghai.
Staphylococcal Superantigen-Like Protein 10 (SSL10) induces necroptosis through TNFR1 activation of RIPK3-dependent signal pathways

Staphylococcal aureus (S. aureus) infection can lead to a wide range of diseases such as sepsis and pneumonia. Staphylococcal superantigen like (SSL) proteins, specifically expressed by S. aureus, are shown to be involved in immune evasion during S. aureus infection. Here, we show that SSL10, an SSL family protein, exhibits potent cytotoxicity against human cells (HEK 293T and HUVEC) by inducing necroptosis upon binding to its receptor TNFR1 on the cell membrane. After binding, two distinct signaling pathways are activated downstream of TNFR1 in a RIPK3-dependent manner, i.e., the RIPK1-RIPK3-MLKL and RIPK3-CaMKII-mitochondrial permeability transition pore (mPTP) pathways. We determined the crystal structure of SSL10 at 1.9 Å resolution and, in conjunction with cytotoxicity analysis of chimeric mutant variants, identified a surface region formed by residues in the N- and C-termini that can potentially serve as the TNFR1 binding site. Knockout of ssl10 in S. aureus profoundly reduced cytotoxicity of culture supernatants, indicating that SSL10 is involved in extracellular cytotoxicity during infection. This study thus provides the first description of cytotoxicity through induction of necroptosis by an SSL protein, and a potential target for clinical treatment of S. aureus-associated diseases.
Theoretical And Computational Studies Of Dissociative Recombination Of H3+ With Low Kinetic Energy Electrons: Time-independent A

Dissociative recombination of molecular ions by collisions with electrons is a reactive collision, in which the electronic kinetic energy is transferred to the excitation of the molecule that, then, dissociates. The goals of this dissertation was (1) to improve existing approaches in theory of DR of triatomic ions in the time-independent framework developed in recent years by Kokoouline and Greene, and (2) to develop a time-dependent theoretical framework for DR treatment based on quantum defect theory. The theoretical method developed by Kokoouline and Greene is based on multichannel quantum defect theory and accounts for the major non-Born-Oppenheimer Jahn-Teller interaction between electronic and vibrational motions of the molecule. The study of this dissertation is partially based on this method but improved, extended, and systematically applied in the framework of my thesis. This dissertation presents the calculated DR rate coefficient for H3 within the time-independent framework and the description of the method used to obtain the (qualitative) flux with timedependent method. The time-independent results show good agreement with experimental data from storage ring experiments. The DR rate coefficients for orthoand para-H3 were calculated separately and show a significant difference at very low electronic energies; a result that agrees with recent storage ring experiments. Also, it is discussed results for other isotopologues of H3 (H2D , D2H , and D3 ) and the results for vibrationally-excited initial states of H3 . It was found that the DR rate coefficients for vibrationally-excited initial states are larger than the rates for the ion initially in the ground vibrational state. At the end, this dissertation discuss the time-dependent calculations done with a diatomic model system.
Inter-professional collaboration between local departments of Social Services and schools for children in foster care: Current practices and needs

iv I. Statement of Problem . 1 Overview of Children in Foster Care and Risk Factors . 1 Treatment Teams . 3 Laws and Regulations that Govern Inter-Professional Collaboration . 4 Inter-Professional Collaboration as a Protective Factor . 5 Challenges of Inter-Professional Collaboration . 7 Role of the School Psychologist . 8 II. Methods.11 Participants . 11 Measures . 11 Procedure . 13 Data Analysis . 13 III. Results . 15 Current Practices in Inter-Professional Collaboration . 17 Difficulties in Collaboration . 19 Points of Contact for Children in Foster Care . 20 Decision Makers for Children in Foster Care . 21 Training of Social Workers Regarding Educational Needs . 22 Interest in Gaining and Providing Additional Training and Knowledge . 23 Perspectives and Primary Considerations . 25 IV. Discussion . 26 Limitations . 29 Implications for Future Training, Practice, and Research . 30 V. Appendices . 32 Appendix A . 32 Appendix B . 39 Appendix C . 41 VI. References . 43
Tchuma Tchato: an evolving experience of community-based natural resource management in Mozambique.

Tchuma Tchato is one of the first community-based natural resource management (CBNRM) programmes established in Mozambique. It started in 1994 in a remote area of about 200 000 ha on the right-hand side of the Zambeze River in Tete Province, close to the borders of Zimbabwe and Zambia. This typical mopane (Colophospermum mopane) forest ecosystem has been a concession area for safari operations since 1993. Because of conflicts between local communities, the private operator and the local government, intervention was required to promote collaborative management of the resources, with stakeholders’ benefits and obligations clearly defined.