Miracle-dz/UniFAR-FTUs huggingface dataset:
Synovial Cells and Glucocorticoids in Primary Rheumatoid Regulated by Proinflammatory Cytokines Microsomal Prostaglandin E Synthase Is

The selective induction of PGE 2 synthesis in inﬂammation suggests that a PGE synthase may be linked to an inducible pathway for PG synthesis. We examined the expression of the recently cloned inducible microsomal PGE synthase (mPGES) in synoviocytes from patients with rheumatoid arthritis, its modulation by cytokines and dexamethasone, and its linkage to the inducible cyclo-oxygenase-2. Northern blot analysis showed that IL-1 b or TNF- a treatment induces mPGES mRNA from very low levels at baseline to maximum levels at 24 h. IL-1 b -induced mPGES mRNA was inhibited by dexamethasone in a dose-dependent fashion. Western blot analysis demonstrated that mPGES protein was induced by IL-1 b , and maximum expression was sustained for up to 72 h. There was a coordinated up-regulation of cyclooxygenase-2 protein, although peak expression was earlier. Differential Western blot analysis of the microsomal and the cytosolic fractions revealed that the induced expression of mPGES protein was limited to the microsomal fraction. The detected mPGES protein was catalytically functional as indicated by a 3-fold increase of PGES activity in synoviocytes following treatment with IL-1 b ; this increased synthase activity was limited to the microsomal fraction. In summary, these data demonstrate an induction of mPGES in rheumatoid synoviocytes by proinﬂammatory cytokines. This novel pathway may be a target for therapeutic intervention for patients with arthritis. The Journal of Immunology, 2001, 167: 469–474.
Hardware-Modellierung und Algorithmus-Optimierung für die dreidimensionale Objekterfassung durch CMOS-Bildsensoren mit Kurzzeitintegration und Laserpulsbeleuchtung

This work analyses a solid state 3D-CMOS camera system for direct time-of-flight image acquisition, which consists of a CMOS imaging sensor, a laser diode module for active narrow infrared laser pulse illumination and all optics for image forming. The investigation is carried out using ideal and real signals. A deterministic model describes the main signal processing. For this the laser pulse function and various integration window function were sampled. The latter were recorded by using the impulse response of a narrow pulse of TFWHM = 63, 44ps. The visual integration windows give a good understanding of differences between ideal and real output function of measurement systems. The influence of noise sources like photon noise, thermal noise and quantization noise was considered. Further investigations related to intensity and time delay of the received laser pulse show how the output voltage noise of the pixel column circuit depends on. The postprocessing algorithm called MDSI was modelled by the sampled laser pulse and integration windows. An extended version of the distance calculation includes an additional time-shift between the laser pulse and the integration window during the first main signal processing. This gives an larger measurement domain. Measurements of the distance-proportional voltage quotient confirm the extended version, which was created in a computer simulation before.
systematicreviewandcriticalevaluationofrepor-tedpathogenicsequencevariantsinhidradenitissuppurativa.BrJDermatol177:987–998 Canoui-PoitrineF,LeThuautA,RevuzJE,VialletteC,GabisonG,PoliF,PougetF,WolkensteinP,Bastuji-GarinS(2013)Identiﬁcationofthreehidradenitissuppurativaphenotypes:latentclassanalysisof

Hidradenitis suppurativa (HS) is a chronic debilitating disease, characterized by recurrent inﬂammatorynodules, abscesses and ﬁstulas in the intertriginous areas. Pain and malodorous discharge lead to profound quality of life impairment.Follicular plugging seems to play a role in the pathomechanism of the disease. Genetic predispositions and several other trigger factors including obesity and smoking are described. HS is diagnosed clinically by the presence of characteristic skin lesions. Hurley staging is used for assessing disease severity. Mild HS is treated with topical antiseptics and antibiotics. In mild to moderateHS, systemic antibiotics (combination clindamycin- rifampicin, tetracyclines)are recommended to achieve temporary remission. The TNF-α inhibitor Adalimumab is approved for the therapy of moderate to severe HS. Surgical interventions play an important role in the treatment of ﬁstulas and scaring. Through wide local excision a circumscribed area can be cured in patients with localized HS. Improving patients’qualityof life remains the top priority.
Integration of dual-clutch transmissions in hybrid electric vehicle powertrains

This dissertation presents a study focused on exploring the integration of DualClutch Transmissions (DCTs) in Hybrid Electric Vehicles (HEVs). Among the many aspects that could be investigated regarding the electrification of DCTs, research efforts are undertaken here to the development of control strategies for improving vehicle dynamic performance during gearshifts and the energy management of HEVs. In the first part of the dissertation, control algorithms for upshift and downshift maneuvers are developed for a Plug-in Hybrid Electric Vehicle (PHEV) architecture in which an electric machine is connected to the output of the transmission, thus obtaining torque filling capabilities during gearshifts. Promising results, in terms of the vehicle dynamic performance, are obtained for the two transmission systems analyzed: Hybrid Automated Manual Transmission (H-AMT) and Hybrid Dual-Clutch Transmission (H-DCT). On the other hand, the global optimal solution to the energy management problem for a PHEV equipped with a DCT is found by developing a detailed Dynamic Programing (DP) formulation. The main control objective is to reduce the fuel consumption during a driving mission. Based on the DP results, a novel real-time implementable Energy Management Strategy (EMS) is proposed. The performance of such controller, in terms of the overall fuel usage, is close to that of the optimal solution. Furthermore, the developed approach is shown to outperform a wellknown causal strategy: Adaptive Equivalent Consumption Minimization Strategy (A-ECMS). One of the main aspects that differentiates the EMSs proposed here to those presented in previous works is the introduction of a model to estimate the energy consumption during gearshifts in DCTs. Thus, this dissertation illustrates how through the electrification of powertrains equipped with DCTs both the vehicle dynamic performance and the energy consumption can be improved.
The Long-Term Consequences of Childbearing: Physical and Psychological Well-Being of Mothers in Later Life

Growing evidence points to relationships between patterns of childbearing and health outcomes for mothers; yet a need remains to clarify these relationships over the long-term and to understand the underlying mechanisms. Using data from the National Longitudinal Survey of Mature Women (N=1,608), I find that the long-term consequences of childbearing vary by health outcome. Early childbearing is associated with higher risk of ADL limitations at ages 65–83, though effects appear stronger among white than black mothers until SES is controlled. Early childbearing is also associated with greater levels of depressive symptomatology, though this association is mediated by SES and health. Late childbearing is associated with more depressive symptoms net of early life and current SES, child proximity and support, and physical health. Finally, I find no significant effects of high parity. These findings emphasize the need to better understand the mechanisms linking childbearing histories to later physical and psychological well-being.
Medical gas cylinder expiry dates â•fi a reply

1. Loadsman JA, McCulloch TJ. Widening the search for suspect data – is the flood of retractions about to become a tsunami? Anaesthesia 2017; 72: 931–5. 2. Carlisle JB. Data fabrication and other reasons for non-random sampling in 5087 randomised, controlled trials in anaesthetic and general medical journals. Anaesthesia 2017; 72: 944–52. 3. Kharasch ED, Houle TT. Errors and integrity in seeking and reporting apparent research misconduct. Anesthesiology 2017; 127: 733–7.
Seasonal variations of ultrafine and sub-micron aerosols in Taipei, 1 Taiwan: implications for particle formation processes in urban areas 2

13 The aim of this study is to investigate the seasonal variations in the physicochemical 14 properties of atmospheric ultrafine particles (UFPs, d ≤ 100nm) and submicron 15 particles (PM 1 , d ≤ 1 µ m) in an East-Asian urban area, which are hypothesized to be 16 affected by the interchange of summer and winter monsoons. An observation 17 experiment was conducted at the TARO (Taipei Aerosol and Radiation Observatory), 18 an urban aerosol station in Taipei, Taiwan, from October 2012 to August 2013. The 19 measurements included the mass concentration and chemical composition of UFPs 20 and PM 1 , as well as the particle number concentration (PNC) and number size 21 distribution (PSD) with size range of 4-736 nm. The results indicated that the mass 22 concentration of PM 1 was elevated during cold seasons with a peak level of 18.5 µ g 23 m -3 in spring, whereas the highest UFPs concentration was measured in summertime 24 with a mean of 1.64 µ g m -3 . Moreover, chemical analysis revealed that the UFPs and 25 PM 1 were characterized by distinct composition; UFPs were composed mostly of 26 organics, whereas ammonium and sulfate were the major constituents in PM 1 . The 27 seasonal median of total PNCs ranged from 13.9×10 3 cm − 3 in autumn to 19.4×10 3 28 cm − 3 in
R Heavy metals risk assessment in water and bottom sediments of ICOLLs in northern Poland

Natural diversity of intermittently closed and open lakes and lagoons (ICOLLs) depends on mutual interactions of several factors: (i) an impact of sea water and land background; (ii) temporary meteorological situation; (iii) hydrological conditions; and (iv) the shape of lake basin. However, some regional, local or even sudden impacts including anthropogenic ones create their final ecological status. To identify heavy metals risk assessment in ICOLLs located in Polish coastline wide range of them were determined in water and bottom sediment samples collected in 10 water reservoirs. Multidimensional data set of 20 variables was explored by the use of chemometrics according to seasonality (Spring, Summer, Autumn), sample type (water, sediment) and level of isolation (fully isolated, partially and fully connected lakes). The results showed that 70.5% and 77% of the data variance can be explained by the use of principal component analysis for waters and sediments, respectively. Waters of fully isolated or partially connected lakes are more abundant with Ir, Nd and Sm, while less abundant with Pr and Sr. Bottom sediments taken from Jamno lake show significant contamination by heavy metals of the highest environmental concern (Al, Cr, Cu, Ni, Ti and Zn).
Re-examining and re-conceptualising enterprise search and discovery capability : towards a model for the factors and generative mechanisms for search task outcomes

Many organizations are trying to re-create the ˜Google experience, to find and exploit their own corporate information. However, there is evidence that finding information in the workplace using search engine technology has remained difficult, with socio-technical elements largely neglected in the literature. Explication of the factors and generative mechanisms (ultimate causes) to effective search task outcomes (user satisfaction, search task performance and serendipitous encountering) may provide a first step in making improvements. A transdisciplinary (holistic) lens was applied to Enterprise Search and Discovery capability, combining critical realism and activity theory with complexity theories to one of the worlds largest corporations. Data collection included an in-situ exploratory search experiment with 26 participants, focus groups with 53 participants and interviews with 87 business professionals. Thousands of user feedback comments and search transactions were analysed. Transferability of findings was assessed through interviews with eight industry informants and ten organizations from a range of industries. A wide range of informational needs were identified for search filters, including a need to be intrigued. Search term word co-occurrence algorithms facilitated serendipity to a greater extent than existing methods deployed in the organization surveyed. No association was found between user satisfaction (or self assessed search expertise) with search task performance and overall performance was poor, although most participants had been satisfied with their performance. Eighteen factors were identified that influence search task outcomes ranging from user and task factors, informational and technological artefacts, through to a wide range of organizational norms. Modality Theory (Cybersearch culture, Simplicity and Loss Aversion bias) was developed to explain the study observations. This proposes that at all organizational levels there are tendencies for reductionist (unimodal) mind-sets towards search capability leading to ˜fixes that fail. The factors and mechanisms were identified in other industry organizations suggesting some theory generalizability. This is the first socio-technical analysis of Enterprise Search and Discovery capability. The findings challenge existing orthodoxy, such as the criticality of search literacy (agency) which has been neglected in the practitioner literature in favour of structure. The resulting multifactorial causal model and strategic framework for improvement present opportunities to update existing academic models in the IR, LIS and IS literature, such as the DeLone and McLean model for information system success. There are encouraging signs that Modality Theory may enable a reconfiguration of organizational mind-sets that could transform search task outcomes and ultimately business performance.
Using Association Rule to Find One Discipline’s Papers Published on Another Discipline’s Journals

Traditionally, when a bibliometrics study for a specific discipline is conducted, the researchers may use various methods trying to cover all the appropriate papers in this discipline. But this process might eliminate papers that should be taken into account but published in a journal which belongs to another discipline. In this paper, the association rule is used to find an author’s one discipline’s papers published on another discipline’s journals, which helps to provide a new method for bibliometrics studies to cover more publications within one discipline.
Investigation on SIW Slot Antenna Array with Beam Scanning Ability

A sparse substrate integrated waveguide (SIW) slot antenna array and its application on phase scanning are studied in this paper. The genetic algorithm is used to optimize the best arrangement for 8-element and 7-element sparse arrays over an aperture of 4. 5λ0. Antenna arrays with feeding networks, for steering the main beam pointing to 0° and −15°, are demonstrated with the SIW technology. The comparison between the sparse array and the conventional uniformly spaced array with the same aperture are presented, which suggest that the same beam width can be obtained with the gain decreased by 0.5 or 1 dBi and the number of element reduced by 2 or 3, respectively. The sparse antenna array with beam scanning ability presented in this paper shows that, while the beam scanning in the range of ±15°, the gain fluctuation is less than 0.3 dBi and the side lobe level is lower than −10 dB.
STUDY TO KNOW PREDICTORS OF MORTALITY IN PATIENTS OF ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

: Background: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) result in increased morbidity, mortality and tremendous socioeconomic burden. Predicting in hospital mortality may aid prognostication, planning for the site of care, i.e., ward versus intensive care units, and better individualization of treatment. Aim of Study: This study aims in predicting in hospital mortality in patients of AECOPD based on the parameters measured at the time of admission. Methods: Known COPD patients in acute exacerbations admitted in a tertiary care hospital were interrogated for clinical history and examination. All relevant laboratory tests including arterial blood gas analysis, complete blood count, liver and renal function tests, and random blood sugar were done. Based on outcome, patients were grouped into survivors and no survivors. Parameters recorded were then subjected for univariate analysis to get their statistical significance. All significant variables on univariate analysis were then analysed further with multivariate analysis. Results: Out of the total 140 patients included in the study, 24 (17%) died during their hospital stay. Of the various acute‑phase parameters recorded at the time of the admission, only five qualified to be predictors of in hospital mortality based on univariate and multivariate analyses. These were partial pressure of carbon dioxide in arterial blood (PaCO 2 ) (odds ratio [OR], 95% confidence interval [CI] =1.067, 0.993–1.146), pH (OR, 95% CI = 0.001, 0.001–0.584), serum glutamic pyruvate transaminase (SGPT) (OR, 95% CI = 1.032, 1.006–1.059), sodium (OR, 95% CI = 0.779, 0.689–0.881), and random blood sugar (OR, 95% CI = 1.018, 1.007–1.029). With these five factors combined, area under receiver operating characteristic (ROC) curve was 0.9684, sensitivity 79.18%, specificity 96.55%, positive predictive value 82.61%, negative predictive value 95.73%, and correctly classify acute exacerbation in 93.57%. Good survival can be expected if these parameters are within normal limits. Conclusion: pH, PaCO 2 , SGPT, serum sodium, and random blood sugar at the time of admission are independent predictors of mortality in patients of AECOPD. These can be helpful in developing a prediction tool of in hospital mortality in such patients.
for the in

We consider the cubic Nonlinear Schr¨odinger Equation (NLS) in one space dimension, either focusing or defocusing. We prove that the solutions satisfy a-priori local in time H s bounds in terms of the H s size of the initial data for s ≥ − 14 . This improves earlier results of Christ-Colliander-Tao [2] and of the authors [12]. The new ingredients are a localization in space and local energy decay, which we hope to be of independent interest.
Effects of assistance of anticipatory driving on driver's behaviour during deceleration situations

In this work, the investigation of the assistance of anticipatory driving is presented. The goal is to explore the effects of such an assistance system on driver's behaviour in deceleration situations. The influence of the system is derived using the comparison between assisted and unassisted drives performed in a fixed-base simulator. The benefits are evaluated via analyzing driving and visual data with respect to safety, comfort, and efficiency criteria. The results show that drivers with assistance start decelerating significantly earlier in some of the investigated situations, predominantly by coasting a vehicle. The mean maximum decelerations are reduced from 8,5m/s2 to 6,2m/s2 in the safety critical situation, and the fuel consumption tends to sink on 4
Response to comments on the article titled Mathematical diagnosis of fetal monitoring using the Zipf-Mandelbrot law and dynamic systems' theory applied to cardiac physiology

RESPUESTA AL COMENTARIO AL ARTICULO “DIAGNOSTICO MATEMATICO DE LAMONITORIA FETAL CON LA LEY DEZIPF-MANDELBROT Y LA TEORIA DELOS SISTEMAS DINAMICOS APLICADOSA LA FISIOLOGIA CARDIACA”Response to comments on the article titled “Mathematical diagnosis of fetal monitoring using the Zipf-Mandelbrot law and dynamic systems’ theory applied to cardiac physiology”
Three-Dimensional Crust and Mantle Structure of Kilauea Three-Dimensional Crust and Mantle Structure of Kilauea Volcano, Hawaii Volcano, Hawaii

Teleseismic P wave arrival times recorded by a dense network of seismograph stations located on Kilauea volcano, Hawaii, are inverted to determine lateral variations in crust and upper mantle structure to a depth of 70 km. The crustal structure is dominated by relatively high velocities within the central summit complex and along the two radial rift zones, compared with the nonrift flank of the volcano. Both the mean crustal velocity contrast between summit and nonrift flank and the distribution of velocities agree well with results from crustal refraction studies. Comparison of the velocity structure with Bouguer gravity anomalies over the volcano through a simple physical model also gives excellent agreement. Mantle structure appears to be more homogeneous than crustal structure. The root mean square velocity variation for the mantle averages only 1.5%, whereas variation within the crust exceeds 4%. The summit of Kilauea is underlain by normal velocity (8.1 km/s) material within the uppermost mantle (12-25 km), suggesting that large magma storage reservoirs are not present at this level and that the passageways from deeper sources must be quite narrow. No evidence is found for substantial volumes of partially molten rock (5%) within the mantle to depths of at least 40 km. Below about 30 km, low-velocity zones (1-2%) underlie the summits of Kilauea and nearby Mauna Loa and extend south of Kilauea into a broad offshore zone. Correlation of volcanic tremor source locations and persistent zones of mantle earthquakes with low-velocity mantle between 27.5- and 42.5-km depth suggests that a laterally extensive conduit system feeds magma to the volcanic summits from sources either at comparable depth or deeper within the mantle. The center of contemporary magmatic production and/or upwelling from deeper in the mantle appears to extend well to the south of the active volcanic summits, suggesting that the Hawaiian Island chain is actively extending to the southeast.
Design, Manufacturing and Analysis of Integrated Motor and Fan Assembly

— the paper deals with optimization of the overall efficiency of a high mass-flow rate axial Fan meant for cooling purpose of electronic devices by shifting the motor assembly towards the rim (making it a rim driven Fan) and reducing the size of the hub. The design procedure aims to improve the blade geometry for reducing the losses due to swirls and vortex thus increasing the overall efficiency of the Fan. The design procedure follows an inverse method where in the air foil sections are derived from the mean-line profiles. The CFD Analysis reveals that the vortex and swirls were reduced to a certain extent as compared to the normal axial Fan with motor mounted in the hub.
The GTPase domain of MX 2 interacts with HIV-1 capsid enabling its short isoform to 1 moderate antiviral restriction 2 3

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