Miracle-dz/UniFAR-FTUs huggingface dataset:
PII: S0925-4773(02)00044-8

Two secreted signaling molecules, wingless (wg) and decapentaplegic (dpp), are required to specify the heart in Drosophila. wg and dpp are also required to specify other cell types within the mesoderm and in many other regions of the embryo. Because the spatial patterns of wg and dpp are dynamic, different populations of mesodermal cells are exposed to different combinations of wg and/or dpp at different times. To determine whether the patterns of wg and dpp expression provide unique positional information for the specification of heart precursors, we altered these patterns. Our data suggest that wg and dpp contribute progressively to the elaboration of the expression pattern of the mesodermspecific homeobox-containing gene tinman (tin), and that the overlap of wg and dpp at an early stage (9) as well as at a later stage (11) in the presence of tin-expressing cells directs cardiac-specific differentiation. Furthermore, ectopic tin expression in the ectoderm at wg/dpp intersects (the primordia of the thoracic imaginal disks) also leads to cardiac-specific differentiation, suggesting that tin confers mesoderm-specificity to the wg/dpp response. We conclude that ectopic heart can be generated by altering the patterns of wg and dpp within the tin-expressing mesoderm, or by ectopic induction of tin within the wgand dpp-expressing ectoderm. q 2002 Elsevier Science Ireland Ltd. All rights reserved.
PII: S0925-4773(99)00084-2

We report here the expression pattern of Nkx3.1, a murine homolog of Drosophila bagpipe, in different stages of embryos and in neonates. Nkx3.1 was expressed in paraxial mesoderm at day 7.5 p.c. , in the somite by day 8.0 p.c. and in a subset of vascular smooth muscle cells by day 9.5 p.c. In later stage embryos and neonates, Nkx3.1 was expressed in subpopulations of epithelial cells, particularly in epithelial outgrowths. Nkx3.1 was also expressed in restricted regions of the central nervous system. q 1999 Elsevier Science Ireland Ltd. All rights reserved.
Further evidence for the importance of this relationship for the survival of Calyptogena comes

importance of this relationship for the survival of Calyptogena comes from the adaptations the clam has made to accommodate the endosymbiont. Sulphur-oxidizing bacteria require sulfide as an electron donor and oxygen as an acceptor (or nitrate in anoxic conditions) to fix carbon. But sulfide and oxygen can react spontaneously, making it difficult for a single-celled organism to obtain both from the environment at the same time [13]. Calyptogena overcomes this barrier for its endosymbionts by arranging the bacteriocytes in the outermost layer of gill epithelial cells, so that they contact both the oxygen (or nitrate)-rich water and the sulfide accumulated in the blood of the clam [14]. Calyptogena sequesters the sulfide by pushing its highly vascularized foot into the substrate, where it can access mineral rich water from the vents while keeping its inhalant siphon in the ambient seawater above. The relationship between C. okutanii and its endosymbiont is clearly essential for the survival of both organisms and manifests itself at multiple levels of organization. The genome sequence of the endosymbiont provides an intriguing window into the biology behind this interaction and how it affects both the clam and the symbiont. As we explore more deep-sea host–symbiont systems it will be fascinating to determine the extent of endosymbiont genome reduction and the parallels between the process of symbiont reduction on land and in the depths of the ocean.
PII: S0925-4773(01)00500-7

The transcriptional programs that specify the distinct components of the cardiac conduction system are poorly understood, in part due to a paucity of definitive molecular markers. In the present study we show that a cGATA-6 gene enhancer can be used to selectively express transgenes in the atrioventricular (AV) conduction system as it becomes manifest in the developing multichambered mouse heart. Furthermore, our analysis of staged cGATA-6/lacZ embryos revealed that the activity of this heart-region-specific enhancer can be traced back essentially to the outset of the cardiogenic program. We provide evidence that this enhancer reads medial/lateral and anterior/posterior positional information before the heart tube forms and we show that the activity of this enhancer becomes restricted at the heart looping stage to AV myocardial cells that induce endocardial cushion formation. We infer that a deeply-rooted heart-region-specific transcriptional program serves to coordinate AV valve placement and AV conduction system formation. Lastly, we show that cGATA-6/Cre mice can be used to delete floxed genes in the respective subsets of specialized heart cells. q 2001 Elsevier Science Ireland Ltd. All rights reserved.
PII: S0925-4773(99)00099-4

Intercellular signalling mediated by Notch proteins is crucial to many cell fate decisions in metazoans. Its profound effects on cell fate and proliferation require that a complex set of responses involving positive and negative signal transducers be orchestrated around each instance of signalling. In Drosophila the basic-helix-loop-helix (bHLH) repressor encoding genes of the E(spl) locus are induced by Notch signalling and mediate some of its effects, such as suppression of neural fate. Here we report on a novel family of Notch responsive genes, whose products appear to act as antagonists of the Notch signal in the process of adult sensory organ precursor singularization. They, too, reside in the E(spl) locus and comprise transcription units E(spl) m4 and E(spl) ma. Overexpression of these genes causes downregulation of E(spl) bHLH expression accompanied by cell autonomous overcommitment of sensory organ precursors and tufting of bristles. Interestingly, negative regulation of the Notch pathway by overexpression of E(spl) m4 and ma is speci®c to the process of sensory organ precursor singularization and does not impinge on other instances of Notch signalling. q 1999 Elsevier Science Ireland Ltd. All rights reserved.
PII: S0925-4773(02)00011-4

Gbx-2 is a homeobox gene essential for normal development of the midbrain and the anterior hindbrain. Zebrafish gbx-2 shares an overall similarity of 67.8, 68.1, 60.6 and 66.5% in amino acid sequence to human, mouse, chick and Xenopus Gbx-2, respectively. The expression of zebrafish gbx-2 is initially, before the completion of epiboly, restricted to the prospective posterior midbrain. The expression remains detectable until the end of pharyngula period. The gbx-2 mRNA is also detected in the otic vesicles, the dorsoposterior telencephalon, the rostral branchial arches, the pronephric duct and median fin fold. q 2002 Elsevier Science Ireland Ltd. All rights reserved.
PII: S0925-4773(01)00614-1

Uterine decidualization, characterized by stromal cell proliferation, and differentiation into specialized type of cells (decidual cells) with polyploidy, during implantation is critical to the pregnancy establishment in mice. The mechanisms by which the cell cycle events govern these processes are poorly understood. The cell cycle is tightly regulated at two particular checkpoints, G1-S and G2-M phases. Normal operation of these phases involves a complex interplay of cyclins, cyclin-dependent kinases (cdks) and cdk inhibitors (CKIs). We previously observed that upregulation of uterine cyclin D3 at the implantation site is tightly associated with decidualization in mice. To better understand the role of cyclin D3 in this process, we examined cell-specific expression and associated interactions of several cell cycle regulators (cyclins, cdks and CKIs) specific to different phases of the cell cycle during decidualization in mice. Among the various cell cycle molecules examined, coordinate expression and functional association of cyclin D3 with cdk4 suggest a role for proliferation and, that of cyclin D3 with p21 and cdk6 is consistent with the development of polyploidy during stromal cell decidualization. q 2002 Elsevier Science Ireland Ltd. All rights reserved.
The Anatomy and Price of an Ideational Conquest: On Steady Stifling of Academe Since the World War II

The object of the monograph is two-fold: a) to discern directions of ideational changes and policy evolution pertaining to notions, functions, and financing of ‘higher education’ (HE) through a critical evaluation of reports/reviews/books/recommendations of a series of landmark committees/commissions/panels/ideologues especially in UK and USA since WWII; b) to assess the corresponding effects of these ideational (and policy) changes (or conquest) on academic standard/quality as well as overall societal contributions of HE. It is shown that a stark neoliberal policy regime has been established across world both via new theoretical (and ideational) constructs/formulations (mainly) by mainstream (neoclassical) economics profession with an active benefaction of the Bretton Woods institutions and other multilateral agencies. But these pro-market ideas/ideology and reforms in the sphere of HE/university (including privatization) are found to have set off – not surprisingly at all – fairly robust temporal (and global) trends of falling academic standard, rigors, and intellectual contributions/capabilities along with rapid growth of HE both as an industry and prospective propellent of foreign trade and profit. The monograph concludes that it is high time that the global leaders rethink about the future of HE as an academe.
Event detection in finance using hierarchical clustering algorithms on news and tweets

In the current age of overwhelming information and massive production of textual data on the Web, Event Detection has become an increasingly important task in various application domains. Several research branches have been developed to tackle the problem from different perspectives, including Natural Language Processing and Big Data analysis, with the goal of providing valuable resources to support decision-making in a wide variety of fields. In this paper, we propose a real-time domain-specific clustering-based event-detection approach that integrates textual information coming, on one hand, from traditional newswires and, on the other hand, from microblogging platforms. The goal of the implemented pipeline is twofold: (i) providing insights to the user about the relevant events that are reported in the press on a daily basis; (ii) alerting the user about potentially important and impactful events, referred to as hot events, for some specific tasks or domains of interest. The algorithm identifies clusters of related news stories published by globally renowned press sources, which guarantee authoritative, noise-free information about current affairs; subsequently, the content extracted from microblogs is associated to the clusters in order to gain an assessment of the relevance of the event in the public opinion. To identify the events of a day d we create the lexicon by looking at news articles and stock data of previous days up to d−1 Although the approach can be extended to a variety of domains (e.g. politics, economy, sports), we hereby present a specific implementation in the financial sector. We validated our solution through a qualitative and quantitative evaluation, performed on the Dow Jones’ Data, News and Analytics dataset, on a stream of messages extracted from the microblogging platform Stocktwits, and on the Standard & Poor’s 500 index time-series. The experiments demonstrate the effectiveness of our proposal in extracting meaningful information from real-world events and in spotting hot events in the financial sphere. An added value of the evaluation is given by the visual inspection of a selected number of significant real-world events, starting from the Brexit Referendum and reaching until the recent outbreak of the Covid-19 pandemic in early 2020.
Metagenome Assembled Genome of a Novel Verrucomicrobial Methanotroph From Pantelleria Island

Verrucomicrobial methanotrophs are a group of aerobic bacteria isolated from volcanic environments. They are acidophiles, characterized by the presence of a particulate methane monooxygenase (pMMO) and a XoxF-type methanol dehydrogenase (MDH). Metagenomic analysis of DNA extracted from the soil of Favara Grande, a geothermal area on Pantelleria Island, Italy, revealed the presence of two verrucomicrobial Metagenome Assembled Genomes (MAGs). One of these MAGs did not phylogenetically classify within any existing genus. After extensive analysis of the MAG, we propose the name of “Candidatus Methylacidithermus pantelleriae” PQ17 gen. nov. sp. nov. The MAG consisted of 2,466,655 bp, 71 contigs and 3,127 predicted coding sequences. Completeness was found at 98.6% and contamination at 1.3%. Genes encoding the pMMO and XoxF-MDH were identified. Inorganic carbon fixation might use the Calvin-Benson-Bassham cycle since all genes were identified. The serine and ribulose monophosphate pathways were incomplete. The detoxification of formaldehyde could follow the tetrahydrofolate pathway. Furthermore, “Ca. Methylacidithermus pantelleriae” might be capable of nitric oxide reduction but genes for dissimilatory nitrate reduction and nitrogen fixation were not identified. Unlike other verrucomicrobial methanotrophs, genes encoding for enzymes involved in hydrogen oxidation could not be found. In conclusion, the discovery of this new MAG expands the diversity and metabolism of verrucomicrobial methanotrophs.
Two Simple Models of Insurance Fraud

We show a simple approach to modelling insurance frauds, both ex-ante (for the insured event), in the form of false accidents and staged events, and ex-post, in the form of inflated bills and buildups. Optimal amounts of (under)coverage and excess claims are obtained from the maximizing behavior of policyholders under perfect competition and fraud detection activity by the insurance companies. Numerical results are calculated using plausible parameter assumptions.
Who is the Best Fit? Ex-ante Beliefs about Auditor-Client Compatibility in the Audit Process

This paper emphasizes the importance of ex-ante beliefs for auditor-client compatibility. High compatibility is characterized by the efficient transformation of audit effort into audit quality. Consequently, common intuition suggests that the highest compatibility guarantees the best outcome to the audit process. However, from an ex-ante perspective, the auditor-client compatibility is unknown to all market participants. In our model, we show that auditors with uncertain compatibility can outperform auditors whose type is known since a successful (unsuccessful) audit has a stronger positive (negative) impact on the market's beliefs if the auditor still has to prove her fit. Thus, given that litigation is rather moderate, auditors with uncertain compatibility have stronger effort incentives than certainly compatible types, which enables them to generate a higher audit surplus. The results highlight that litigation and market mechanisms provide a unique set of incentives for each auditor and cannot be viewed as perfect substitutes.
Best Value-Total Quality Management for Local Government?

This article argues that Best Value is a form of Total Quality Management (TQM). At the core of Best Value are the TQM principles of customer focus, continuous improvement and team-working. To discover if Best Value will deliver the performance improvements expected of local government, the authors examine evidence on the relationship between TQM and performance. Performance is most likely to be improved if the whole TQM approach is implemented in the Best Value framework.
Targeting gut dysbiosis as a means to enhance recovery from surgical brain injury

Background: Surgical brain injury (SBI) impacts roughly 800,000 people who undergo neurosurgical procedures each year. SBI is the result of unavoidable parenchymal damage, vessel disruption, and thermal injury that is an inherent part of all neurosurgical procedures. Clinically, SBI has been associated with postoperative seizures and long-term neurobehavioral deficits. Current therapies are aimed at providing symptom relief by reducing swelling and preventing seizures. However, there are no therapies aimed at reducing the extent of SBI preoperatively. The microbiome-gut-brain axis may serve as a potential target for the development of new preventative therapies due to its extensive involvement in central nervous system function. Methods: An extensive literature review was conducted to determine whether there is a potential role for dysbiosis treatment in reducing the extent of SBI. Results: Treatment of gut dysbiosis deserves further exploration as a potential means of reducing the extent of unavoidable SBI. Dysbiosis has been correlated with increased neuroinflammation through impaired immune regulation, increased blood-brain barrier permeability, and increased production of reactive metabolites. Recently, dysbiosis has also been linked to acute neurological dysfunction in the postoperative state. Importantly, treatment of dysbiosis has been correlated with better patient outcomes and decreased length of stay in surgical patients. Conclusion: Current literature supports the role of dysbiosis treatment in the preoperative setting as a means of optimizing neurological recovery following unavoidable SBI that results from all neurosurgical procedures.
Clinical features of a series of patients in life-threatening situations at a COVID-19 pandemic field hospital, evaluated by teleconsultation: evidence for Telemedicine expansion

Tarso Augusto Duenhas Accorsi1, Alexandra Régia Dantas Brigido1, Karine De Amicis1, Deborah de Sá Pereira Belfort1, Fábio Cetinic Habrum1, Fernando Garcia Scarpanti1, Iuri Resedá Magalhães1, José Roberto de Oliveira Silva Filho1, Leon Pablo Cartaxo Sampaio1, Maria Tereza Sampaio de Sousa Lira1, Renata Albaladejo Morbeck1, Carlos Henrique Sartorato Pedrotti1, Fábio de Castro Jorge Racy2, Eduardo Cordioli1
Cerebral Venous Thrombosis and Its Clinical Diversity

Cerebral venous thrombosis (CVT) is a serious medical condition which is difficult to diagnose because of its wide range of clinical presentations. The symptoms can vary from an isolated headache to coma. Here, we present the case of a 76-year-old female patient with a history of immune thrombocytopenic purpura, arterial hypertension, and pulmonary embolism. The diagnosis of CVT was challenging because the initial form of disease presentation mimicked a transient ischemic attack (transient aphasia and right hemiparesis). Therapeutical decisions were also a challenge because, at the time of the diagnosis, the patient was suffering from severe thrombocytopenia (29 × 109/L), which had to be taken into account. After multidisciplinary discussions, therapeutic subcutaneous enoxaparin was started, resulting in a progressive and significant neurological recovery. In presenting this case, our primary goal is to point out that CVT can be difficult to diagnose because of its wide range of clinical presentations. Headache (a symptom that was never present in this case) is the most frequent complaint, occurring in 90% of cases. Following diagnosis, an etiological study is required.
Swiss Finance Institute Research Paper Series N°21-33

60 million tweets are scraped from Stocktwits.com over 10 years and clas-siﬁed into bullish, bearish or neutral classes to create ﬁrm-individual polarity time-series. Changes in polarity are associated with changes of the same sign in contemporaneous stock returns. On average, polarity is not able to predict next-day stock returns but when we focus on speciﬁc events (deﬁned as sudden peak of tweet activity), polarity has predictive powers on abnormal returns. Finally, we show that bad events act more as surprises than good events.
Preparation and Characterization of Activated Carbon from Raw Red Macroalgae and Bio Char from Macroalgae

This article discusses the preparation and characterization of activated carbon by the combined method (combination of two methods of chemical activation by ZnCl 2 and physical CO 2 ) leads to essentially microporous coals with specific BET specific surfaces which can exceed 800 m 2 /g. It is generally obtained by the BET method which is based on the adsorption capacity (in vapor phase) of nitrogen at 77 K and the steric hindrance of the N2 molecule. Microporous activated carbon prepared from Moroccan red macroalgae can be used as excellent carriers for adsorbing small molecules like heavy metals and other organic molecules like pesticides. This work was devoted to the characterization of active carbon prepared from red macroalgae with H 3 PO 4 , ZnCl 2 , CO 2 , H 3 PO 4 / CO 2 , ZnCl 2 / by TFIR, BET and SEM.
Labor Share, Foreign Demand and Superstar Exporters

This paper proposes a new determinant of labor share changes. Using micro-data on the universe of French manufacturing exporters over 1995-2007, I show that a measure of export demand growth exogenous to firm-level outcomes drives down the manufacturing labor share through two effects. First, foreign demand shocks allow low-labor share, highly internationalized “superstar” exporters to grow disproportionately more. Second, foreign demand growth decreases the labor share of exporters and this effect is stronger for larger exporters. Both effects explain 12% of the labor share decline over 1995-2000 and led to a 1.2 percentage point drop over 2000-2007. A simple model of endogenous competition with heterogeneous firms rationalizes the findings. A market size increase allows exporters to expand, which decreases their share of fixed labor cost in value-added, and increases competition on international markets. Fiercer competition favors superstar exporters, further decreasing their labor share through the fixed cost channel. Overall, these findings provide direct causal evidence of a “winner take most” phenomenon induced by trade globalization. <br>
IMMU-11. CLINICAL UPDATES AND CORRELATIVE FINDINGS FROM THE FIRST PATIENT WITH DIPG TREATED WITH INTRACRANIAL CAR T CELLS

Abstract We report preliminary data for the first subject with diffuse intrinsic pontine glioma (DIPG) treated with intracranial CAR T cells. BrainChild-03 (NCT04185038) is a phase 1 trial of repetitively-dosed locoregional B7-H3-specific CAR T cells for children with recurrent/refractory central nervous system (CNS) tumors or DIPG. DIPG patients enroll on Arm C, on which B7H3CARs are delivered into the ventricular system via a CNS reservoir catheter. This study does not use lymphodepletion. Primary endpoints are feasibility and safety, with second endpoints of disease response. This 18-year-old female (BrainChild-03 S005) with radiographically-classic DIPG and biopsy-confirmed H3 K27M mutation enrolled on Arm C after progression 552 days from diagnosis following focal radiation and temozolomide, irinotecan, and bevacizumab. Apheresis and manufacturing produced 4.2x109 second-generation B7H3CARs with a methotrexate-resistant human DHFR mutein (huDHFRFS; L22F,F31S) in a single transcript in combination with the B7-H3-specific CAR and EGFRt, each separated by a T2A linker, allowing methotrexate selection and enrichment. At time of submission, she has received 10 every-other-week outpatient infusions of 1x107 B7H3CARs (first dose on October 2, 2020). She has had no DLTs, but has experienced grade 2 fever and grade 2–3 headache peaking ~12–48 hours after each infusion. Following the 8th CAR T cell infusion, she experienced increased focal weakness and dysarthria at ~72 hours with resolution after 48 hours. She has not experienced cytokine release syndrome (CRS). She has stable disease 138 days post-initial CAR T cell infusion. Frequently collected correlative studies have detected viable B7H3CARs in the CSF post-infusion via flow cytometry. CSF cytokine analysis has revealed elevations of CXCL10, GM-CSF, and G-CSF following B7H3CAR infusions, without correlation in the serum. A second evaluable subject with DIPG has also received 4 locoregional doses of 1x107 B7H3CARs without a DLT. She also has stable disease and detectable viable B7H3CARs in the CSF.