Miracle-dz/UniFAR-FTUs huggingface dataset:
Construction of a Prognostic m6A-related lncRNA Signature to Predict Immunotherapy and Chemotherapy Response in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the main causes of cancer-related deaths worldwide. N6-methyladenosine (m6A) and long noncoding RNA (lncRNA) are two common modifications that affect tumor development and play vital roles in the prognosis of HCC. Therefore, we comprehensively analyzed transcriptome data from the Cancer Genome Atlas (TCGA) and identified lncRNAs related to m6A regulators. Univariate, LASSO, and multivariate Cox regression analyses were used to build a prognostic model. Patients were then divided into low- and high-risk groups according to the optimal cut-off point. The prognosis value of the novel model was evaluated using Kaplan-Meier analysis and the receiver operating characteristic curve. Besides, mutation and immune profiles together with immune checkpoint expressions were further explored to identify the difference in somatic alteration and tumor immune landscape between the two groups. Additionally, a better response to conventional chemotherapy and immunotherapy was found in patients with the high-risk group, but they were more resistant to sorafenib. The m6A-related lncRNAs model might be used to predict the prognosis and drug responses in patients with HCC.
Some Properties of Time Varying Networks

In this paper, the general theory of reactance amplifiers is exemplified, with attention centered on three aspects. 1. Why may gain be obtained from a nonlinear reactance and not from a nonlinear resistance? 2. Where there is gain and feedback, the possibility of oscillation exists. But the situation is more complex than it is with vacuum tube amplifiers because the feedback path is through the modulator so that an external impedance at one frequency may be reflected as an impedance at another frequency. 3. The particular case of three frequencies, e.g., p, g, p-q, is calculated for large signals. The phenomena of regeneration and oscillation, with subharmonic oscillation as a special case, are studied and illuminated.
Dual‐frequency circularly polarized antenna

Spatial communication systems need antennas circularly polarized. In this article, we propose a new compact dual‐frequency circularly polarized antenna. The two circular polarizations obtained in each frequency band are on opposite sense. This antenna is a patch of dimensions 36 × 36 mm2, printed on duroid substrate. Left hand circular polarization and right hand circular polarization maximum gains are 6.46 dB at the low frequency and 7.14 dB at the high frequency. Theoretical total efficiency is about 91% in the two bands. Parametric study shows that each frequency band can be controlled separately and that circular polarization can be maintained in each band. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 177–180, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23028
Gating of Substrate Access and Long-Range Proton Transfer in Escherichia coli Nitrate Reductase A: The Essential Role of a Remote Glutamate Residue

The Mo/W- bis PGD enzyme superfamily comprises a vast number of mononuclear molybdenum and tungsten enzymes that catalyze a great diversity of vital reactions in prokaryotes. In the past decades, much attention has been devoted to the immediate surroundings of the metal atom highlighting the importance of the inner coordination sphere but have failed to identify molecular determinants of the reactivity. Here, we report the mechanistic importance of a set of conserved residues that line the substrate entry tunnel in Escherichia coli nitrate reductase A (Nar), a paradigmatic enzyme of the Mo/W- bis PGD superfamily. Using mutagenesis, enzyme kinetics, electron paramagnetic resonance spectroscopy and molecular dynamics, we unveil the pivotal role of Glu-581 motion and a number of polar residues in its close proximity in substrate affinity and proton transfer to the Mo active site. Motion of the side chain of Glu-581 exhibiting a strong acid-base cooperativity with Asp-801 and surrounded by several polar interactions controls the hydration inside the protein core, proton transfer and substrate selectivity towards the active site. Overall, we identify an additional determinant that fine-tunes the reactivity and selectivity in Nar and propose that a gating mechanism is at play in several other members of the superfamily.
A study on friction behavior of rapeseed oil as an environmentally friendly additive in lubricating oil

Today's worries and doubts related to the use of mineral oils increased because of the worldwide interest in environmental issues. This issue has increased the use of vegetable oils as an alternative lubricating oil candidate, environment‐friendly lubricant and their additives. In this study, rapeseed oil (RSO) in different concentrations, 1, 2, 3, 5, 10, 20, 30, 40, 50 (by volume percent), was added to base oil to obtain a lubricating oil candidate. Turkish originated RSO was studied as an additive candidate in this paper. The study of the effect of additives in mineral oils was carried out using a specially designed experimental system to compare lubricating oil candidates and high temperatures using engine journal bearings under statically loaded.
Assistance Of Students In The Framework Of Global Hinness Through Community Games And Traditional Sports

In the era children who spend most of their time in coffee shops and internet cafes, just to play online games. 2020 is a tough year, because the world is being hit by the Covid-19 pandemic, a healthy body is the main point to be able to carry out movement activities properly, a healthy body and good movement are obtained through one suitable activity, namely sports activities. One model of learning gross motoric movements through folk games and traditional sports because it can be conveyed to students more easily, fun, according to the stages of development, characteristics, and age. Implementation of character value mentoring through folk games and traditional sports, through direct practice in games, giving flascards of character and module values, the teacher serving as a facilitator, the result was that 79% of students showed increased understanding of folk games and the characters in them.
Analysis of pre‐qualification criteria in contractor selection and their impacts on project success

While construction industry practices are reasonably well developed, construction projects still witness widespread failures of many contractors due to varied reasons such as financial problems, poor management, over‐commitment and or conflicts and disputes associated with construction activities. Pre‐qualification of contractors is a common practice across projects, yet the investigation on the ability of the selected contractors in successful delivery of projects is not widespread. In an attempt to understand these pre‐emptive qualification criteria and their links in contractors’ performance in projects, a total of 43 influencing technical attributes were identified through a systematic research approach. The relative significance and impacts of the attributes have been determined based on a structured questionnaire survey in selected construction projects. By performing the factor analysis, a total of seven factors significant to contractors’ performance were extracted, namely (1) soundness of business and workforce; (2) planning and control; (3) quality management; (4) past performance; (5) risk management; (6) organizational capability; and (7) commitment and dedication. Multiple linear regression models reveal that technical expertise, past success, time in business, work methods and working capital significantly impact on contractors’ performance across time, cost and quality success. With a clear understanding of a contractor’s performance, these findings could potentially contribute to development of a company’s procedures or enhance existing knowledge in relation to the pre‐qualification practices in contractor selection in projects.
Design of micron MOS switching devices

Summary form only only given, as follows. Modern photolithographic technology offers the capability of fabricating MOSFET devices of micron dimensions and less. It is by no means obvious that such small devices can be designed with suitable electrical characteristics for LSI switching applications. In this talk we will describe short-channel devices (Leff ~ l μ) designed by scaling down larger devices with desirable electrical characteristics. Lateral and vertical dimensions, doping level, and operating voltages and currents are scaled in a self-consistent fashion. In this way small devices have been fabricated without the usual deleterious effects associated with short channels. The measured characteristics of these short-channel devices and the larger devices from which they were scaled will be compared. The scaling procedure helps to better understand the limitations of miniaturization of MOS devices. Significant problems are encountered when operating voltages become comparable to the band gap which cannot be scaled within the silicon technology. The subthreshold characteristic of the device then becomes an important consideration. [This reprint (and two more from 1973 and 1974) show the difference between conference and journal reporting in the 1970s. When the concept of scaling first saw the light of day at IEDM in 1972, only an abstract remained as an archive report. By 1973, the IEDM Digest provided a broader overview of Dennard's report. Dennard's 1974 explanation of scaling turned out to be the most cited article in the 51 year history of the JSSC, close to 700 times, according to the last count in 2005 by the independent citation report firm, Thomson ISI. ]
Multirobot Control Strategies for Collective Transport

One potential application of multirobot systems is collective transport, a task in which multiple robots collaboratively move a payload that is too large or heavy for a single robot. In this review, we highlight a variety of control strategies for collective transport that have been developed over the past three decades. We characterize the problem scenarios that have been addressed in terms of the control objective, the robot platform and its interaction with the payload, and the robots’ capabilities and information about the payload and environment. We categorize the control strategies according to whether their sensing, computation, and communication functions are performed by a centralized supervisor or specialized robot or autonomously by the robots. We provide an overview of progress toward control strategies that can be implemented on robots with expanded autonomous functionality in uncertain environments using limited information, and we suggest directions for future work on developing such controllers. Expected final online publication date for the Annual Review of Control, Robotics, and Autonomous Systems, Volume 5 is May 2022. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Tooth-ripple losses in solid poles

It is shown, both theoretically and experimentally, that the reaction of eddy currents on the inducing tooth-ripple field, previously considered to be negligible, can be very large. This has an important effect on the subsequent calculation of loss in both turbogenerators and salient-pole machines. A comprehensive set of results, giving the pole-face field for the possible ranges of design values, is presented. These show that the two main parameters are the permeability of the pole material and the length of the air gap. The analysis on which the computation of results is based is quite general, and previous analyses of the tooth-ripple and related problems, apparently dissimilar, are correlated in the light of it.
A New Design for Variable Diameter Orifice Mechanism

Variable diameter orifice is required in many applications e.g. smokestacks coal furnaces, liquid dispensing machines, wall fans, gas handling systems, pipes, vacuum chambers air valves, fluid control systems, ventilation systems, ducts, spot lights, holes of golf sports, photography nozzles, solid free fabrications and vacuum valves [1–17]. The need for variable diameter is to control the medium transfer through the orifice. In this abstract, a new design for a variable diameter orifice is introduced. Designing a variable diameter orifice is a challenging problem due to the need of circular geometry of the orifice opening. Many designs have been conducted to design a variable diameter orifice. However, the proposed designs are either have non circular opening or require a bulky size mechanism. In the proposed design, simplicity, size and actuation are our main concern.Copyright © 2012 by ASME
Clinical Evaluation of Left Ventricular Diastolic Function Using Phase-contrast Cine Cardiovascular Magnetic Resonance Imaging: A Comparison With Steady-state Free Precession Cine Cardiovascular Magnetic Resonance Imaging and Echocardiography

Objective We investigated a practical method using phase-contrast (PC) cine cardiovascular magnetic resonance imaging to estimate peak filling rate and early/atrial velocity (E/A) as left ventricular diastolic function indicators. Methods Peak filling rate and E/A were estimated in 32 patients using PC imaging with high spatial or high temporal resolution and compared with those estimated using steady-state free precession cine cardiovascular magnetic resonance imaging and echocardiography. Results Peak filling rate estimated using PC imaging significantly correlated with those estimated using steady-state free precession imaging despite apparent underestimation using PC imaging with high spatial resolution. The E/A estimated using PC imaging significantly correlated with those estimated using echocardiography. Conclusions Peak filling rate and E/A measurements using PC imaging with high temporal resolution is convenient and acceptably accurate, suggesting its potential for clinical use.
A Low Power Fully Differential Level-Crossing ADC With Low Power Charge Redistribution Input for Biomedical Applications

A low-power fully differential level-crossing analog-to-digital converter (LC-ADC) for biomedical applications is presented. Different from conventional ADCs based on the uniform sampling rate, LC-ADC generates fewer samples for biomedical signals and leads to less power consumption in the following blocks. In this design, the power consumption of n-bit DAC and digital parts is reduced significantly with respect to the conventional LC-ADCs. The proposed method uses a charge redistribution block (CRB) instead of the n-bit DAC, which leads to a large reduction in average switching energy. Besides energy-saving, the proposed switching scheme also reduces the complexity of the controlling logic circuit, providing reduced complexity and low power consumption. Another advantage of the proposed LC-ADC is its fully differential structure. As a result, SNDR is improved by decreasing the levels of even harmonics. The proposed LC-ADC is designed in 0.18 <inline-formula> <tex-math notation="LaTeX">$\mu {\mathrm{ m}}$ </tex-math></inline-formula> CMOS technology. Post-layout simulation results show an effective number of bits (ENOB) of up to 6.8 bits with about 97–188 nW power consumption under 0.8 V supply voltage and input signal bandwidth from 1 Hz to 4 kHz. The ADC occupies a silicon area of only <inline-formula> <tex-math notation="LaTeX">$60\mathbf {\times }65\,\,\mu \text{m}^{2}$ </tex-math></inline-formula>
Development of an MR compatible rotating anode x-ray tube

In order to achieve a truly hybrid, high quality X-ray/MR system one must have a rotating anode x-ray source as close as possible to the bore of the high-field MR magnet. Full integration between a closed bore MR system and an x-ray fluoroscopy system presents two main challenges that must be addressed: x-ray tube motor operation and efficiency in an external field, and focal spot deflection. Regarding the first challenge our results have shown that an AC induction motor operating in external fields will experience a drop off in efficiency. Specifically, fields on the order of 100 Gauss perpendicular to the rotor decrease the rotation speed from 2450 RPM to below 1800 RPM. We are currently developing an alternate brushless DC motor design that would exploit the presence of the external MR fringe field and our initial finite element results indicate that the necessary amount of torque is produced. Regarding the second challenge our results show that an external field of 195 Gauss perpendicular to the anode-cathode axis (BR direction) produces a focal spot deflection of 5 mm. For the fields at which we want to operate the x-ray tube (~to 1000 Gauss along BR) this deflection will be significantly larger than 5 mm and must be corrected for. We propose a design that includes active deflection coils which serve to counteract the presence of the external field and reduce the focal spot deflection to less than 1 mm in our simulations.
Multi Folded Dual rectangle loop Type Dual Monopole Antenna

In this paper, multi folded dual monopole antenna for WLAN communication of dual bend is designed and fabricated. The proposed multi folded dual monopole antenna are consisted of two folded rectangle loops by microstrip fed that is modified dual monopole antenna. Therefore, the outside rectangle loop structure of the proposed antenna is extended a dual monopole. The characteristics of the proposed antenna is analyzed return loss and radiation patterns by the FDTD tools. As a result a bandwidth of proposed antenna has about 0.82GHz from 2.0 to 2.82[GHz] and 0.7GHz from 5.46 to 6.16[GHz]. It is used WLAN communications of 2[GHz] and 5[GHz].
Examining the competing effects of contemporary land management vs. land cover changes on global air quality

Abstract. Our work explores the impact of two important dimensions of land system changes, land use and land cover change (LULCC) as well as direct agricultural reactive nitrogen (Nr) emissions from soils, on ozone (O3) and fine particulate matter (PM2.5) in terms of air quality over contemporary (1992 to 2014) timescales. We account for LULCC and agricultural Nr emissions changes with consistent remote sensing products and new global emission inventories respectively estimating their impacts on global surface O3 and PM2.5 concentrations as well as Nr deposition using the GEOS-Chem global chemical transport model. Over this time period, our model results show that agricultural Nr emission changes cause a reduction of annual mean PM2.5 levels over Europe and northern Asia (up to −2.1 µg m−3) while increasing PM2.5 levels in India, China and the eastern US (up to +3.5 µg m−3). Land cover changes induce small reductions in PM2.5 (up to −0.7 µg m−3) over Amazonia, China and India due to reduced biogenic volatile organic compound (BVOC) emissions and enhanced deposition of aerosol precursor gases (e.g., NO2, SO2). Agricultural Nr emission changes only lead to minor changes (up to ±0.6 ppbv) in annual mean surface O3 levels, mainly over China, India and Myanmar. Meanwhile, our model result suggests a stronger impact of LULCC on surface O3 over the time period across South America; the combination of changes in dry deposition and isoprene emissions results in −0.8 to +1.2 ppbv surface ozone changes. The enhancement of dry deposition reduces the surface ozone level (up to −1 ppbv) over southern China, the eastern US and central Africa. The enhancement of soil NO emission due to crop expansion also contributes to surface ozone changes (up to +0.6 ppbv) over sub-Saharan Africa. In certain regions, the combined effects of LULCC and agricultural Nr emission changes on O3 and PM2.5 air quality can be comparable (>20 %) to anthropogenic emission changes over the same time period. Finally, we calculate that the increase in global agricultural Nr emissions leads to a net increase in global land area (+3.67×106km2) that potentially faces exceedance of the critical Nr load (>5 kg N ha−1 yr−1). Our result demonstrates the impacts of contemporary LULCC and agricultural Nr emission changes on PM2.5 and O3 in terms of air quality, as well as the importance of land system changes for air quality over multidecadal timescales.
Reliability Analysis of Combing Opportunistic Scheduling and Transmit Antenna Selection with Zero-Forcing Receivers in SM-MIMO Systems

In this paper, we propose a novel scheme combing opportunistic schedule (OS) and transmit antenna selection (Tx-AnSS) with ZF receivers under imperfect channel estimation in SM-MIMO systems, where the user set and the transmit antenna subset are adaptively selected according to channel state information (CSI), which is feedback from the receive side. First, we derive the average effective SNR and both analytical forms and approximation expressions for outage probability and BER expression, showing that combining multiuser diversity (MUD) and Tx-AnSS in SM-MIMO systems provides much larger diversity and better performance than the scheme without MUD or Tx-AnSS. Further, the diversity gains for both outage probability and BER expression are also quantified through asymptotic analysis.
Immittance converters suitable for power electronics

An immittance converter has fine performance in many power electronics applications. Its function is to convert voltage sources into current sources and current sources into voltage sources. The immittance converter has an input impedance that is proportional to the admittance of loads connected across output terminals. Therefore, in this converter, the output current is proportional to the input voltage and the input current is proportional to the output voltage. Consequently, it converts a constant voltage source into a constant current source and a constant current source into a constant voltage source. When an immittance converter operates at a resonant frequency and is inserted to high-frequency link systems, voltage source outputs turn into current source outputs and current source outputs turn into voltage source outputs. Some power electronics applications of this converter are photovoltaic inverters and dc-dc converters with constant current outputs. It is well known that a quarter-wavelength transmission line shows immittance conversion characteristics. However, it has a very long line length for its switching frequency (e.g., 20 kHz), and is not suitable for power electronics applications. Therefore we propose five immittance converters that consist of lumped L and C elements and show the immittance conversion characteristics at a resonant frequency. These immittance converters are much smaller and lighter than the transmission line. Their principles, basic circuits, and basic characteristics are described in this paper. We also evaluate their application to high-frequency link systems of power electronics. © 1998 Scripta Technica, Electr Eng Jpn, 124(2): 53–62, 1998
Carrier-wave interference to Loran-C: a statistical evaluation

Loran-C is a pulsed, hyperbolic radio aid for long-range marine, air, and land navigation. The worldwide expansion of Loran-C, especially in Europe, has focused attention on carrier-wave interference to the system. The effects of a multiplicity of carrier-wave interferers (CWIs) on receiver timing measurement accuracy are considered. Both the phase tracking and the cycle-selection performance of receivers are quantified in terms of the probabilities that they will operate correctly within the arbitrarily set error limits. Characteristic functions (CFs) are used to compute these probabilities. Analyses and results are presented for typical situations. The relative sensitivity of the phase tracking and cycle-selection functions to interfering signals are discussed. >