Miracle-dz/UniFAR-FTUs huggingface dataset:
Greenhouse Gas Emissions in the Everglades: The Role of Hydrologic Conditions 1

1. This document is SL288, one of a series of the Soil and Water Science Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Original publication date May 2009. Visit the EDIS Web Site at http://edis.ifas. ufl.edu. 2. Alan L. Wright, assistant professor, Department of Soil and Water Science, Everglades Research and Education Center (REC)-Belle Glade; K. R. Reddy, professor, Department of Soil and Water Science; Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32611.
A Functional Variant Alters the Binding of Bone morphogenetic protein 2 to the Transcription Factor NF-κB to Regulate Bone morphogenetic protein 2 Gene Expression and Chicken Abdominal Fat Deposition

Simple Summary Bone morphogenetic protein 2 (BMP2) is crucial in numerous biological processes including osteogenesis, adipogenesis, and myogenesis. Our previous study has demonstrated that a 12-base pair (bp) insertion/deletion (InDel) variant (namely g.14798187_14798188insTCCCTGCCCCCT) within intron 2 of the chicken BMP2 gene was significantly associated with chicken abdominal fat weight and abdominal fat percentage. However, the molecular mechanism underlying this association remains elusive. This study aimed to investigate whether the 12-bp InDel variant is a functional marker that affects the expression of the chicken BMP2 gene and potential regulatory mechanism using both a dual-luciferase reporter assay and electrophoretic mobility shift assay in vitro. The results revealed that the 12-bp InDel chicken BMP2 gene variant is a functional variant affecting fat deposition in chickens, which may also partially regulate BMP2 gene expression by affecting the binding of transcription factor NF-κB to the BMP2 gene. The findings will offer a potential functional molecular marker for improving the abdominal fat content of chickens in molecular breeding such as genome editing and genomic selection. Furthermore, the findings will also contribute to the understanding of the underlying roles of the BMP2 gene in the growth and development of chicken adipose tissues. Abstract In this study, we employed a dual-luciferase reporter assay and electrophoretic mobility shift analysis (EMSA) in vitro to explore whether a 12-base pair (bp) insertion/deletion (InDel) variant (namely g.14798187_14798188insTCCCTGCCCCCT) within intron 2 of the chicken BMP2 gene, which was significantly associated with chicken abdominal fat weight and abdominal fat percentage, is a functional marker and its potential regulatory mechanism. The reporter analysis demonstrated that the luciferase activity of the deletion allele was extremely significantly higher than that of the insertion allele (p < 0.01). A bioinformatics analysis revealed that compared to the deletion allele, the insertion allele created a transcription factor binding site of nuclear factor-kappa B (NF-κB), which exhibited an inhibitory effect on fat deposition. A dual-luciferase reporter assay demonstrated that the inhibitory effect of NF-κB on the deletion allele was stronger than that on the insertion allele. EMSA indicated that the binding affinity of NF-κB for the insertion allele was stronger than that for the deletion allele. In conclusion, the 12-bp InDel chicken BMP2 gene variant is a functional variant affecting fat deposition in chickens, which may partially regulate BMP2 gene expression by affecting the binding of transcription factor NF-κB to the BMP2 gene.
First Report of Morchella -An Edible Morel from Mount Abu, Rajasthan

Morchella, commonly referred as 'guchhi' in India, belongs to family Helvellaceae. This saprophytic fungus is known throughout the world for its higher market price. Its nutritional values coupled with medicinal importance made this mushroom as a subject of interest to researchers across the world. Large scale cultivation of the ascocarps of this fungus is a distant dream to them till today. Present article reports the occurrence of this economically important morel in Rajasthan state.
Unlocking Nanotechnology Adoption Intention in the Malaysian Food Industry

The purpose of this study is to investigate the factors that motivate nanotechnology adoption in the food industry. The study collects 101 responses from food industry operators in Klang Valley, Malaysia, via a quantitative field survey. The data was analysed using Structural Equation Modelling (SEM). The findings show that effort expectation, price value, and trust have no statistical impact on nanotechnology adoption, whereas performance expectancy and top management support have positive effects. Given that this study is one of the few that investigates factors influencing nanotechnology adoption, it should give useful information for future studies on the food industry and nanotechnology adoption among researchers and practitioners.
The Tolerogenic Influence of Dexamethasone on Dendritic Cells Is Accompanied by the Induction of Efferocytosis, Promoted by MERTK

Many treatments for autoimmune diseases, caused by the loss of immune self-tolerance, are broadly immunosuppressive. Dendritic cells (DCs) can be induced to develop anti-inflammatory/tolerogenic properties to suppress aberrant self-directed immunity by promoting immune tolerance in an antigen-specific manner. Dexamethasone can generate tolerogenic DCs and upregulates MERTK expression. As MERTK can inhibit inflammation, we investigated whether dexamethasone’s tolerogenic effects are mediated via MERTK, potentially providing a novel therapeutic approach. Monocyte-derived DCs were treated with dexamethasone, and with and without MERTK ligands or MERTK inhibitors. Flow cytometry was used to assess effects of MERTK modulation on co-stimulatory molecule expression, efferocytosis, cytokine secretion and T cell proliferation. The influence on expression of Rab17, which coordinates the diversion of efferocytosed material away from cell surface presentation, was assessed. Dexamethasone-treated DCs had upregulated MERTK expression, decreased expression of co-stimulatory molecules, maturation and proliferation of co-cultured T cells and increased uptake of myelin debris. MERTK ligands did not potentiate these properties, whilst specific MERTK inhibition only reversed dexamethasone’s effect on myelin uptake. Cells undergoing efferocytosis had higher Rab17 expression. Dexamethasone-enhanced efferocytosis in DCs is MERTK-dependent and could exert its tolerogenic effects by increasing Rab17 expression to prevent the presentation of efferocytosed material on the cell surface to activate adaptive immune responses.
Theoretical and Pragmatical Challenges in Game Studies in Brazil

ABSTRACT Background: The video game industry is increasing worldwide and Brazil is the leading market in South America. Abuse of video games has been an international concern for a few decades and the World Health Organization included gaming disorder in the 11th version of the International Classification of Diseases. Method: In this article, we cite some academic works and our own experiences to reflect about obstacles commonly found by researchers, beginning with the lack of a consensual definition of what is gaming. Then, we show some characteristics of the Brazilian scenario regarding research about gaming in general and clinical practices about gaming disorder in particular and discuss how sociopolitical traits may impact them. Conclusions: Finally, we discuss some options to avoid pathologizing normal behaviour and the importance of connections between psychiatrists and other groups from within and outside academia, such as researchers from game design and politicians, respectively. Arrière-plan: L’industrie des jeux vidéo se développe dans le monde entier et le Brésil est le marché principal d’Amérique du Sud. L’abus de jeux vidéo est une préoccupation internationale depuis quelques décennies et l’Organisation mondiale de la santé a inclus le trouble du jeu dans la 11e version de la classification internationale des maladies. Mèthode: Dans cet article, nous passons en revue certains obstacles fréquemment rencontrés par les chercheurs, à commencer par l’absence de définition consensuelle de ce qu’est le jeu. Ensuite, nous montrons certaines caractéristiques du scénario brésilien concernant la recherche sur le jeu en général et les pratiques cliniques sur le trouble du jeu en particulier, et nous discutons de la manière dont les caractéristiques sociopolitiques peuvent les influencer. Conclusion: Enfin, nous discutons de certaines options pour éviter de pathologiser un comportement normal et de l’importance des liens entre les psychiatres et d’autres groupes à l’intérieur et à l’extérieur du monde universitaire, tels que respectivement les chercheurs en conception de jeux et les politiciens.
Exploring differences of visual attention in pedestrian navigation when using 2D maps and 3D geo-browsers

ABSTRACT Despite the now-ubiquitous two-dimensional (2D) electronic maps, three-dimensional (3D) globe viewers, or 3D geo-browsers such as Google Earth and NASA World Wind have gained much attention. However, the effect of such interactive 3D geo-browsers on spatial knowledge acquisition and decision-making is not well known. This study aims to explore the potential benefits of using interactive 3D geo-browsers in three processes of pedestrian navigation (self-localization, spatial knowledge acquisition, and decision-making) in digital environments. We employed eye tracking to show differences of visual attention in pedestrian navigation between a 2D map (Google Map) and a 3D geo-browser (Google Earth). The results indicated that benefits and drawbacks of 3D representations are task dependent. Participants using the 3D geo-browser had an extensively visual search resulting in significantly longer response time than the 2D participants for spatial knowledge acquisition, whereas 3D users performed a more efficient visual search and resulted in a better navigation performance at complex decision points. We speculate that the inefficient knowledge acquisition when using the 3D geo-browser was most probably due to information overload and obstructed views. Landmarks in photorealistic 3D models assisted recall of spatial knowledge from mental maps, which contributed to efficient decision-making at a complex turning point. These empirical results can be helpful to improve the usability of pedestrian navigation systems.
After the Euro and Interstate Banking: Present Monetary and Financial Surfacing Conflicts 2023

This paper reconsiders the outcome of the adoption of a single legal currency in the 1999 Euro Act. Installing a central bank, several different solutions surfaced among the EU members and in the global economy, since the 1922 Genoa summit. The last Euro solution came after the severe, unexpected stock market crash on October 19, 1987. Furthermore, the sub-prime bubble 2007, the financial collapse 2008 and the final 2012 the banking melt down, induce to reconsider the overlapping monetary and financial fallouts. The 89 Interstate Banking Act and the Riegle Community Development and Regulatory Improvement Act of 1994, induce a monetary and financial evolving infrastructure. This paper focuses on the conflicts at the enlarging EU community seen the unavoidable monetary and financial integration, considering that the unique definition of the monetary functions as its essence is misinterpreted, in a clear common asymmetry affecting the whole evolving situation.
IoT Sensor Network for Wild-Animal Detection near Roads

The monitoring and detection of wild animals is a significant topic for researchers who study the behavior, lifestyle, and environment of wild animals, as well as for people who encounter wildlife both in residential areas and near roads while traveling. An innovative wild-animal detection internet-of-things (IoT) sensor network running on harvested solar energy and detection methodology is described in this article. The sensor-networks node is implemented via the principle of an embedded system incorporating passive infrared sensors, a long-range (LoRa) module, and a solar panel for energy harvesting. For experimental purposes, a small IoT sensor network was implemented near the road. The network consists of eight nodes placed near the road with a distance of 50 m between nodes, a gateway for gathering detection data from the nodes, and a thermo-vision camera for verification of the received data.
Logic-in-Memory Approach Realizing Memristor-Based Multiplexers

Instead of the von Neumann architecture, logic-in-memory (LIM) provides a revolutionary approach to promoting computing efficiency. Based on the earlier work of complete LIM 16 Boolean logics, this article describes a memristor-based multiplexer (MUX) efficiently realized using a voltage/resistor-input-resistor-output (V/R-R) logic method, despite the fact that MUX is one of complicated logics in the design of VLSI circuits. Following that, a unique 2–1 MUX is further created by merging destructive resistor-input-resistor-output (R-R) logic with V/R-R logic, resulting in further device reduction. The 2–1 MUX only requires 3–4 memristors and four steps. Furthermore, the technique can be implemented for a 4–1 MUX using seven memristors and ten steps. Tests and simulations validated their feasibility and correctness. The effect of resistor due to the flip voltage variation on the computation accuracy is further analyzed, and the cascaded serial scheme of the MUX is finally presented.
Effectiveness of Valsartan’s Single-Pill Combination Therapies on Blood Pressure Control in Hypertensive Patients: Malaysian Single-Centre Real-World Experience

Background Uncontrolled hypertension can cause cardiovascular disease and is an important public health issue. Single-pill combination (SPC) therapies possess combined blood pressure (BP)-lowering effect and may improve compliance to treatment. This study assessed the effectiveness of valsartan (Val)-based SPC therapies in achieving BP control in hypertensive patients. Methods This was a retrospective study. Data were extracted from the hybrid medical records of patients from the Institut Jantung Negara (IJN), Malaysia. Adults with established diagnosis of hypertension and on prescription of Val-based SPC therapies as part of routine medical care from 1 January 2013 to 31 December 2018, with ≥ 1 year of follow-up were included. Primary endpoint was proportion of patients achieving therapeutic BP control (BP < 140/90 mmHg). Secondary outcomes included change from baseline (CFB) in systolic BP (SBP) and diastolic BP (DBP), and subgroup analysis was based on baseline SBP categories and presence of diabetes. Results Study included 409 hypertensive patients. The mean (standard deviation [SD]) age of the population was 65.1 (10.6) years old, with male predominance (61.6%). Proportion of patients achieving target BP between baseline and follow-up were 57.0% (P < 0.001). Mean CFB in SBP and DBP were recorded as 19.52 mmHg and 7.47 mmHg, respectively. Over half of the patients achieved the target BP in all subgroups categorised by SBP at baseline, except the subgroup of SBP 160 mmHg–179 mmHg. SPC therapies were continued in 97.3% of patients at 1-year follow-up. Conclusion Patients using Val-based SPC therapies had significant reduction in BP with good tolerability, with 57% of patients achieving target BP over a prolonged 1-year follow-up period. Uptake of SPC therapy is warranted to improve patient care and outcomes in hypertension.
An Experimental Study on Ultrasonic Vibration-Assisted Turning of Aluminum Alloy 6061 with Vegetable Oil-Based Nanofluid Minimum Quantity Lubrication

Minimum quantity lubrication (MQL) is a potential technology for reducing the consumption of cutting fluids in machining processes. However, there is a need for further improvement in its lubrication and cooling properties. Nanofluid MQL (NMQL) and ultrasonic vibration-assisted machining are both effective methods of enhancing MQL. To achieve an optimal result, this work presents a new method of combining nanofluid MQL with ultrasonic vibration assistance in a turning process. Comparative experimental studies were conducted for two types of turning processes of aluminum alloy 6061, including conventional turning (CT) and ultrasonic vibration-assisted turning (UVAT). For each turning process, five types of lubricating methods were applied, including dry, MQL, nanofluid MQL with graphene nanosheets (GN-MQL), nanofluid MQL with diamond nanoparticles (DN-MQL), and nanofluid MQL with a diamond/graphene hybrid (GN+DN-MQL). A specific cutting energy and areal surface roughness were adopted to evaluate the machinability. The results show that the new method can further improve the machining performance by reducing the specific cutting energy and areal surface roughness, compared with the NMQL turning process and UVAT process. The diamond nanoparticles are easy to embed on the workpiece surface under the UVAT process, which can increase the specific cutting energy and Sa as compared to the MQL method. The graphene nanosheets can produce the interlayer shear effect and be squeezed into the workpiece, thus reducing the specific cutting energy. The results provide a new way for the development of eco-friendly machining.
Real-time monitoring method for surface roughness of γ -TiAl alloy based on deep learning of time-frequency diagram

: γ-TiAl alloy is a typically difficult material to machine, and machining defects such as grain pull-out and material spalling are common during machining, resulting in component scrap. As a result, it is critical to investigate the real-time monitoring method of surface roughness during milling. A new model for predicting surface roughness is proposed in this article. Based on the idea of deep learning, the prediction problem of surface roughness is turned into a classification problem. The features of the force signal are extracted using a continuous wavelet transform, and the one-dimensional signal is converted into a two-dimensional time-frequency diagram to obtain more information. The transfer learning mechanism is introduced to make the model run faster and improve prediction accuracy. The overfitting problem is solved and the model's generalization ability is improved through batch normalization and dropout layer, and the prediction accuracy is increased by 3%. The results show that the method has high recognition accuracy, with a maximum classification accuracy of 98% and an average accuracy of 96.12%, a 6% improvement over the traditional model, allowing it to accurately realize real-time monitoring of surface quality in milling processing.
Apoptosis mechanisms induced by 15d-PMJ2 in HCT116 colon cancer cells: insights into CHOP10/TRB3/Akt signaling

Agents that stimulate the endoplasmic reticulum (ER) stress pathway are being exploited pharmacologically to induce cancer cell death. Cytotoxic ER stress is typically regulated by the transcription factor, C/EBP homologous protein 10 (CHOP10). Products of CHOP10 transcription include the pro-apoptotic proteins: ER oxidoreductase 1α (ERO1α), death receptor-5 (DR5), and tribbles-related protein 3 (TRB3). Our previous findings showed cell death induced by 15-deoxy- Δ12,14 prostamide J2 (15d-PMJ2) occurred in an ER stress-dependent manner. However, the pathway by which 15d-PMJ2 regulates ER stress-mediated death downstream of CHOP10 has not been identified. Our results demonstrate 5 µM 15d-PMJ2 increased CHOP10 expression and apoptosis in HCT116 colon cancer cells. In cells treated with pharmacological inhibitors of ER stress, 15d-PMJ2-induced apoptosis was reliant upon the ER stress pathway. To investigate the role of CHOP10 and its transcriptional products in apoptosis, genetic deletion of CHOP10 (CHOP10-KO) was performed using the CRISPR/Cas9 system. The apoptotic action of 15d-PMJ2 was blunted in cells lacking CHOP10 expression. The deletion of CHOP10 reduced the expression of DR5, ERO1α, and TRB3 although only the expression of TRB3 was significantly reduced. Therefore, we overexpressed TRB3 in CHOP10-KO cells and observed that the activation of Akt was inhibited and 15d-PMJ2-induced apoptosis was restored. Thus, a mechanism of apoptosis elicited by 15d-PMJ2 includes the stimulation of CHOP10/TRB3/Akt inhibition. Given the important role these signaling molecules play in cancer cell fate, 15d-PMJ2 may be an effective inducer of apoptosis in cancer cells.
Evolution of the Paleovegetation, Paleoenvironment and Paleoclimate During Pliocene-early Pleistocene in Zhada Basin, Ali, Tibet

This paper divided the the fluvio-lacustrine facies sedments of Zhada basin into Xiangzi formation during late Pleistocene in Quaternary, Guge formation and Tuolin formationfour during Pliocene in Neogene. The dating results of paleomaguetism and ESR show that zhada basin sedments development between Pliocene in Neogene and Pleistocene in Quaternary. Based on the depositional evolution of the fluvio-lacustrine facies sedments, character of sporopollen assemblage,zoolites, plant fossils and so on, the authors discuss the paleovegetation, paleoenvironment and paleoenvironmental evolution during Pliocene-early Pleistocene in Zhada basin. They think that the climate change from wet-hot, warm-wet, little cold-wet, to cold-drought, and the vegetational evolution from forest, bush, to grassland in Zhada area. The environmental evolution can be divided into 7 phase in Zhada basin, and the character of every phase as follow: ①during 5.4～4.4Ma, Zhada basin was in wet-hot subtropic climate;②during 4.4～3.95Ma, was in warm-wet temperate zone climate;③during 3.95～3.5Ma, was in little cold-wet phase and begin to cold climate;④during 3.5～3.2Ma,was in warm humid phase; ⑤during 5 3.2～2.9Ma,was in little cold-wet phase;⑥during 2.9～2.57Ma, was in little cold-drought climate; ⑦during 2.57～1.36Ma, was in very cold-drought climate. This results show that during Pliocene-early Pleistocene, the main trend of the climate was from warm to cold, from wet to drought, but there were some obviously fluctuate.
Characteristics and seasonal dynamics of the soil arthropod community in Gannan section of the Daxia River wetland

For understanding the characteristics of structure,diversity and seasonal dynamics of soil arthropod community in Gannan section of the Daxia River wetland,an investigation was conducted at six plots in spring, summer and autumn with field sampling method. It is found that( 1) a total of 35 groups and 8 743 soil arthropod were captured,including 2 743 large-size ones and 6 000 small / medium-size ones,which belong to 3 classes,9 orders and 33 families. Large-size soil arthropod accounts for 35. 52% of the total,small / medium-size soil arthropod accounts for 64. 48% of the total. The dominant groups of large-size soil arthropod include Chironomidae and Doilchopodidae; small / medium-size soil arthropod include Sejidae,Trombidiidae,Isotoma and Proisotoma;( 2) There are significantly seasonal variation in the composition and individuals of soil arthropod community,and the sequences of seasonal dynamics of groups and individual number of the soil arthropod are characterized by autumn summer spring;( 3) The vertical distributions of the group and individual density in a soil profile are characterized by concentration in surface in the depth range of 0 ~ 5 cm and decline with depth. These results will provide useful data for ecological study of soil arthropod in arctic-alpine wetland.