Miracle-dz/UniFAR-FTUs huggingface dataset:
Pediatric glioblastoma cells are sensitive to drugs that inhibit eIF2α dephosphorylation and its phosphomimetic S51D variant

We found that pediatric glioblastoma (PED-GBM) cell lines from diffuse intrinsic pontine glioma (DIPG) carrying the H3K27M mutation or from diffuse hemispheric glioma expressing the H3G34R mutation are sensitive to the combination of vorinostat (a histone deacetylase inhibitor) and PARP-1 inhibitors. The combined treatment increased the phosphorylation of eIF2α (P-eIF2α) relative to each drug alone and enhanced the decrease in cell survival. To explore the role played by increased P-eIF2α in modulating PED-GBM survival and response to treatments, we employed brain-penetrating inhibitors of P-eIF2α dephosphorylation: salubrinal and raphin-1. These drugs increased P-eIF2α, DNA damage, and cell death, similarly affecting the sensitivity of DIPG cells and derived neurospheres to PARP-1 inhibitors. Interestingly, these drugs also decreased the level of eIF2Bϵ (the catalytic subunit of eIF2B) and increased its phosphorylation, thereby enhancing the effect of increased P-eIF2α. Transient transfection with the S51D phosphomimetic eIF2α variant recapitulated the effect of salubrinal and raphin-1 on PED-GBM survival and sensitivity to PARP-1 inhibitors. Importantly, either salubrinal or raphin-1 dramatically increased the sensitivity of DIPG cells to radiation, the main treatment modality of PED-GBM. Finally, PED-GBM was more sensitive than normal human astrocytes to salubrinal, raphin-1, and the treatment combinations described herein. Our results indicate that combinations of histone deacetylase inhibitors and PARP-1 inhibitors should be evaluated for their toxicity and efficacy in PED-GBM patients and point to drugs that increase P-eIF2α or modulate its downstream effectors as a novel means of treating PED-GBM.
Exploration on the collaborative innovation path of college students' ideological education and psychological education

As a highly practical educational activity, mental health education must be guided by rich theories to maintain the steady development of mental health education. Ideological education plays a predictive role in college students' crisis management, which can improve college students' psychological crisis management ability. This paper proposes an early warning index system and applies it to the construction of an early warning mechanism, completes the qualitative and quantitative analysis of early warning information evaluation, and changes the situation that information evaluation only stays at the level of qualitative analysis in traditional methods. Quantitative analysis is more conducive to accurately predict the occurrence of psychological crisis. Through empirical research, this paper finds that there is a significant interaction between stressors and coping styles in the process of affecting mental health. The result of interaction is not only equal to the superposition of the influence of a single factor, but also greater or lesser than the superposition of the influence of a single factor. The study found that there was a significant correlation between stressors and mental health. It is one of the many factors that affect mental health, and it is also the main reason to induce college students' psychological crisis. Mature coping styles are significantly positively correlated with mental health, while immature coping styles are significantly negatively correlated with mental health. This paper tests students, which is more conducive to the timely warning of psychological crisis.
Necrotizing pneumonia in children: Chest computed tomography vs. lung ultrasound

Background The utilization of contrast-enhanced computed tomography (CT) of the chest for the diagnosis of necrotizing pneumonia (NP), a complication of community-acquired pneumonia, is controversial because of the inherent ionizing radiation involved. Over the past few years, the growing availability of bedside Lung Ultrasound (LUS) devices has led to increased use of this nonionizing imaging method for diagnosing thoracic pathology, including pneumonia. Objective The objectives of this study were as follows: first, to compare the performance of LUS vs. CT in the identification of certain radiological signs of NP, and second, to determine whether LUS could replace CT in the diagnosis of NP. Materials and methods We compared retrospectively the CT and LUS images of 41 patients between 2005 and 2018 in whom at least one contrast-injected chest CT scan and one LUS had been undertaken fewer than 7 days apart. Results Pleural effusions were demonstrated almost systematically (100% on CT vs. 95.8% on LUS). Visualization of septations in pleural effusions was clearly superior on LUS (20.4% on CT vs 62.5% on LUS). Concerning the detection of necrosis, we observed a strong correlation between LUS and the gold-standard CT (95.8% on LUS vs. 93.7% on CT). Parenchymal cavities were more easily detected on CT than on LUS (79.1 vs. 35.4%). Conclusion LUS has shown to be as effective as CT in the diagnosis of NP. The use of CT in patients with NP could be limited to the detection of complications such as bronchopleural fistulae in unfavorably evolving diseases.
Editorial: Women in science: Public mental health 2021

COPYRIGHT © 2022 Kozasa and Nicholson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Editorial: Women in science: Public mental health 2021
Constant-Time Testing and Learning of Image Properties

We initiate a systematic study of sublinear-time algorithms for image analysis that have access only to labeled random samples from the input. Most previous sublinear-time algorithms for image analysis were query-based, that is, they could query pixels of their choice. We consider algorithms with two types of input access: sample-based algorithms that draw independent uniformly random pixels, and block-sample-based algorithms that draw pixels from independently random square blocks of the image. We investigate three basic properties: being a half-plane, convexity, and connectedness. For the first two, our algorithms are sample-based; for connectedness, they are block-sample-based. All our algorithms have low sample complexity that depends polynomially on the inverse of the error parameter and is independent of the input size. We design algorithms that approximate the distance to the three properties within a small additive error or, equivalently, tolerant testers for being a half-plane, convexity and connectedness. Tolerant testers for these properties, even with query access to the image, were not investigated previously. Tolerance is important in image processing applications because it allows algorithms to be robust to noise in the image. We also give (non-tolerant) testers for convexity and connectedness with better complexity than our distance approximation algorithms and previously known query-based testers. To obtain our algorithms for convexity, we design two fast proper PAC learners of convex sets in two dimensions that work under the uniform distribution: non-agnostic and agnostic.
Evaluation of the cardiovascular risk in patients undergoing major non-cardiac surgery: role of cardiac-specific biomarkers

Abstract Major adverse cardiovascular events are frequently observed in patients undergoing major non-cardiac surgery during the peri-operative period. At this time, the possibility to predict cardiovascular events remains limited, despite the introduction of several algorithms to calculate the risk of adverse events, mainly death and major adverse cardiovascular events (MACE) based on the clinical history, risk factors (sex, age, lipid profile, serum creatinine) and non-invasive cardiac exams (electrocardiogram, echocardiogram, stress tests). The cardiac-specific biomarkers natriuretic peptides (NPs) and cardiac troponins (cTn) have been proposed as additional tools for risk prediction in the peri-operative period, particularly for the identification of myocardial injury in patients undergoing major non-cardiac surgery. The prognostic information from the measurement of BNP/NT-proBNP and hs-cTn is independent and complementary to other important indicators of risk, also including ECG and imaging techniques. Elevated levels of cardiac-specific biomarkers before surgery are associated with a markedly higher risk of MACE during the peri-operative period. BNP/NT-proBNP and hs-cTn should be measured in all patients during the clinical evaluation before surgery, particularly during intermediate- or high-risk surgery, in patients aged >65 years and/or with comorbidities. Several questions remain to be assessed in dedicated clinical studies, such as how to optimize the management of patients with raised cardiac specific biomarkers before surgery, and whether a strategy based on biomarker measurement improves patient outcomes and is cost-effective.
R E Q U E S T FOR PREPROPOSALS FOR SCIENTIFIC RESEARCH AT THE

study, we recreate the four forecasts using data available through the National Centers for Environmental Prediction-National Center for Atmospheric Research (NCEP-NCAR) 50-year reanalysis project. A comparison of the original and reconstructed forecasts shows them to be in good agreement. Quantitative verification of the forecasts yields surprising results: On the basis of root-mean-square errors, persistence beats the forecast in three of the four cases. The mean error, or bias, is smaller for persistence in all four cases. However, when SI scores (Teweles and Wobus 1954) are compared, all four forecasts show skill, and three are substantially better than persistence.
Auction Algorithms for Path Planning, Network Transport, and Reinforcement Learning

We consider some classical optimization problems in path planning and network transport, and we introduce new auction-based algorithms for their optimal and suboptimal solution. The algorithms are based on mathematical ideas that are related to competitive bidding by persons for objects and the attendant market equilibrium, which underlie auction processes. However, the starting point of our algorithms is diﬀerent, namely weighted and unweighted path construction in directed graphs, rather than assignment of persons to objects. The new algorithms have several potential advantages over existing methods: they are empirically faster in some important contexts, such as max-ﬂow, they are well-suited for on-line replanning, and they can be adapted to distributed asynchronous operation. Moreover, they allow arbitrary initial prices, without complementary slackness restrictions, and thus are better-suited to take advantage of reinforcement learning methods that use oﬀ-line training with data, as well as on-line training during real-time operation. The new algorithms may also ﬁnd use in reinforcement learning contexts involving approximation, such as multistep lookahead and tree search schemes, and/or rollout algorithms.
Continued miniaturisation of assay technologies drives market for NANOLITRE DISPENSING

reviewed nanolitre dispensing in pharma drug discovery and highlighted the need for instrumentation that could support enabling miniaturised assays (in volumes of <5μL)1. Specifically we identified nanolitre compound reformatting (direct nanolitre transfer of compounds into assay plates with no intermediate dilutions) and low volume bulk reagent addition to miniaturised assays as key liquid handling processes in need of improved robust liquid handling systems. Two years on we see an increasing diversity of products available or emerging to support these processes and protein crystallography (see Table 1), but are customers now convinced of the maturity of the technology, is now the time to invest more in nanolitre dispensing and to consider replacement of older, obsolete or first generation systems? Survey points to growing market If the results of a recent industry market survey (HTStec’s Nanolitre Dispensing Trends 2004) are correct then we can expect to see significant growth in this segment of the liquid handling market over the next few years, while sales of more traditional dispensers and pipettors with a higher volumetric capacity are predicted to decline marginally in the pharma sector (see Figure 1). As a proportion of the total liquid handling budget the percentage spent on nanolitre dispensing is predicted to rise from 16% in 2003, to 27% in 2004, to 42% in 2005, representing annual growth rates of 45% in 2004 and 65% in 2005. In Table 1 we have listed some examples of the ever increasing variety of nanolitre dispensing devices that are available today or are in development. Instruments are split into dispenser groups mainly on the basis of their underlying dispensing By Dr John Comley
Improved 2D rebinning of helical cone-beam CT data using John's equation

This paper describes a method to improve the accuracy of the rebinning algorithms for helical cone-beam CT. Rebinning algorithms separate the 3D field-of-view into independent oblique slices. Each ray-sum in the sinogram of an oblique slice is approximated by a measured ray-sum that diverges from the helix segment. Because the measured ray-sum does not generally lie within the oblique slice, the method is approximate. John's partial differential equation is a consistency condition for the 3D X-ray transform. We show how John's equation can be used to compute a first order correction to the advanced single slice rebinning algorithm. The improved rebinning algorithm is evaluated using simulated data.
An Introduction to the Field of AeroFencing (AEROBICFENCING)

This paper attempts to introduce Aerofencing as a young kind of sport in which athletes perform combining rhythmic choreography with footwork and handwork of fencing with elements of aerobic and aerobic dance to music. Additionally, it reports the results of an experiment that aimed to combine aerobic exercise and fencing as a new field called AeroFencing for improving asymmetric fencing exercise and helping reduce injuries. Fencers from the experimental group underwent four-week AeroFencing training, while those from the control group underwent regular fencing training. The fencers' performance was analyzed two times: before the practical training (pretest)and after four weeks of training (posttest) in the Columbus Fencing & Fitness. Participants passed three tests that just studied the anaerobic power and speed of the dominant and non-dominant sides of the body. The fencers from the experimental group generally performed better in posttests than in pretests. The results showed that the training protocol of the present study caused a significant improvement in the anaerobic power, hand speed at the time of the attack, and leg speed of the participants in the experimental group compared to the control group. is a routine that is a combination of movements set to a specific count on both sides of the body. AeroFencing practices are based on music counts. Exercises are performed in counts of two. A good illustration, two advanced to the right. Change this into a four-count exercise by adding two advances on the left side. Combine your exercises to fill 16 counts by adding various basic footwork with aerobic dance exercises the same as Mambo or V-Step. A 16-count pattern fits with music rhythms. When you repeat this pattern, you have a 32-count routine that will flow with the current music style.
Kinesin-5 and kinesin-14 are partially antagonistic in spindle assembly in the holocentric silkworm B. mori cells

We previously showed that the silkworm holocentric spindles are square-shaped, compared to the canonical oval shape of human monocentric spindles (Vanpoperinghe et al. 2021). Further, while kinesin-5 depletion resulted in monopolar spindles in both cells, kinesin-14 depletion affected only the silkworm cells, resulting in mal-shaped spindles (Vanpoperinghe et al. 2021). We now extend our study to quantify the effect of kinesin-5 and kinesin-14 on spindle assembly dynamics and chromosome segregation in holocentric silkworm BmN4 cells. We find that mal-shaped spindle and prolonged mitosis duration are highly correlated with chromosome segregation error, leading to aneuploidy and cell death in BmN4 cells. Further, double RNAi-mediated depletion of kinesin-5 and kinesin-14 partially rescue the monopolar spindle and mal-shaped spindle phenotypes in kinesin-5 and kinesin 14-depleted cells, respectively.
Ethics of Care as a Legitimizing Structure from the Perspective of Transhumanism

Postmodern ethics precisely regulate the actions of the postmodern individual. Unlike modern ethics, that have an imperative character, postmodern ethics are constructed and adapted to a changing society, in the context of the ever-accelerating development of technology and the transhumanist proposals for bioimprovement. Thus, postmodern ethics propose a set of norms intended to contribute to the creation and shaping of desirable behavior in the current socio-cultural context. The analysis of postmodern ethics in this paper is made due to the fact that a number of proposals, such as transhumanist ones, are controversial and are intensely debated in scientific communities. An example in this sense is given by Julian Săvulescu, in the article "Deaf lesbians «designer disability», and the future of medicine", which raises a series of questions regarding bioimprovement and what the use of new technologies in order to create disabilities entails.
Zero dissipation limit to rarefaction wave with vacuum for 1-D compressible Navier-Stokes equations

It is well-known that one-dimensional isentropic gas dynamics has two elementary waves, i.e., shock wave and rarefaction wave. Among the two waves, only the rarefaction wave can be connected with vacuum. Given a rarefaction wave with one-side vacuum state to the compressible Euler equations, we can construct a sequence of solutions to one-dimensional compressible isentropic Navier-Stokes equations which converge to the above rarefaction wave with vacuum as the viscosity tends to zero. Moreover, the uniform convergence rate is obtained. The proof consists of a scaling argument and elementary energy analysis based on the underlying rarefaction wave structures.
Induction versus adjuvant chemotherapy combined with concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma: a retrospective cohort study

Background: Currently available evidence favors the combination of chemotherapy with concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma (LANPC). However, the optimal timing for additional chemotherapy is unclear. This study was conducted to compare the efficacy and toxicity of induction chemotherapy plus concurrent chemoradiotherapy (IC+CCRT) versus concurrent chemoradiotherapy plus adjuvant chemotherapy (CCRT+AC). Methods: Two medical centers in China enrolled patients with LANPC (stage III-IVB) between January 2009 and May 2020. Through the use of propensity score matching (PSM), baseline characteristics were balanced. The primary endpoint was overall survival (OS), which was evaluated by the Kaplan-Meier method and log-rank test. Potential independent prognostic factors were identified using univariate and multivariate Cox proportional hazard analyses. Based on the chi-squared test, we compared the adverse events associated with treatment between the groups. Results: After the implementation of PSM, 159 patients treated with IC+CCRT and 72 patients treated with CCRT+AC were eventually enrolled in this study. There was no significant difference between patients treated with IC+CCRT and CCRT+AC in terms of 3-year OS (94.7% versus 90.9%, p=0.816), progression-free survival (PFS) (91.2% versus 83.1%, p=0.588), locoregional recurrence-free survival (LRFS) (92.5% versus 81.8%, p=0.478), or distant metastasis-free survival (DMFS) (93.4% versus 88.2%, p=0.783). There was no prognostic significance of the treatment for OS, PFS, LRFS, or DMFS (all p > 0.05) in the univariate and multivariate analyses. Patients treated with CCRT+AC had a higher incidence of grade 3 to 4 leucopenia (p=0.001) and neutropenia (p=0.001) than those treated with IC+CCRT. Conclusions: IC plus CCRT achieved comparable survival outcomes to CCRT plus AC and had a lower incidence of toxicity.
Facial Expressions and Self-Reported Emotions When Viewing Nature Images

Many studies have demonstrated that exposure to simulated natural scenes has positive effects on emotions and reduces stress. In the present study, we investigated emotional facial expressions while viewing images of various types of natural environments. Both automated facial expression analysis by iMotions’ AFFDEX 8.1 software (iMotions, Copenhagen, Denmark) and self-reported emotions were analyzed. Attractive and unattractive natural images were used, representing either open or closed natural environments. The goal was to further understand the actual features and characteristics of natural scenes that could positively affect emotional states and to evaluate face reading technology to measure such effects. It was predicted that attractive natural scenes would evoke significantly higher levels of positive emotions than unattractive scenes. The results showed generally small values of emotional facial expressions while observing the images. The facial expression of joy was significantly higher than that of other registered emotions. Contrary to predictions, there was no difference between facial emotions while viewing attractive and unattractive scenes. However, the self-reported emotions evoked by the images showed significantly larger differences between specific categories of images in accordance with the predictions. The differences between the registered emotional facial expressions and self-reported emotions suggested that the participants more likely described images in terms of common stereotypes linked with the beauty of natural environments. This result might be an important finding for further methodological considerations.
Design of a Water Supply Distribution Network Using Epanet 2.0: A Case Study of Maiduguri Zone 3, Nigeria

Maiduguri Water Supply Scheme designed by its consultants in 1983 has divided the town into five water supply distribution zones. Zone 3 is one of three remaining zones in the city without a distribution network supplied from the Maiduguri water treatment plant. Consequently, residents obtain water from local water vendors, who retrieve the water from shallow boreholes which has proven to be tedious, cost ineffective and physically exhausting. A water supply network was proposed with the aid of EPANET software and the results obtained conformed to the design criteria established by the previous designers of the Scheme. A total water demand, projected for the year 2031 of 420LPS, minimum pressure head of 14.08m and maximum velocity of flow in the pipes of 1.24m/s was obtained. The use of EPANET software has proven to be time saving and its application is especially for the analysis of larger distribution networks is recommended.