Miracle-dz/UniFAR-FTUs huggingface dataset:
Resilience and Stress during Pregnancy: A Comprehensive Multidimensional Approach in Maternal and Perinatal Health

This narrative review addresses resilience and stress during pregnancy, which is part of a broader concept of maternal health. Pregnancy and postpartum are opportune periods for health promotion interventions, especially because the close contact of the women with health professionals. In this way, it can be considered a useful window of opportunity to identify women at higher risk for adverse outcomes. Integrated health is a concept that aims at providing comprehensive care related to the promotion of individuals' physical, mental, and social well-being. In this context, stress during pregnancy has been targeted as a remarkable condition to be addressed whether due to individual issues, social issues, or specific pregnancy issues, since it is directly and indirectly associated with pregnancy complications. Stress is associated with preterm birth, postpartum depression, anxiety, child neurodevelopment, and fetal distress. The way that an individual faces a stressful and adverse situation is called resilience; this reaction is individual, dynamic, and contextual, and it can affect maternal and fetal outcomes. Low resilience has been associated with poorer pregnancy outcomes. The social context of pregnancy can act as a protective or contributory (risk) factor, indicating that environments of high social vulnerability play a negative role in resilience and, consequently, in perceived stress. A given stressor can be enhanced or mitigated depending on the social context that was imposed, as well as it can be interpreted as different degrees of perceived stress and faced with a higher or lower degree of resilience. Understanding these complex mechanisms may be valuable for tackling this matter. Therefore, in the pregnancy-puerperal period, the analysis of the stress-resilience relationship is essential, especially in contexts of greater social vulnerability, and is a health-promoting factor for both the mother and baby.
Meta Self-Learning for Multi-Source Domain Adaptation: A Benchmark

In recent years, deep learning-based methods have shown promising results in computer vision area. However, a common deep learning model requires a large amount of labeled data, which is labor-intensive to collect and label. What’s more, the model can be ruined due to the domain shift between training data and testing data. Text recognition is a broadly studied field in computer vision and suffers from the same problems noted above due to the diversity of fonts and complicated backgrounds. In this paper, we focus on the text recognition problem and mainly make three contributions toward these problems. First, we collect a multi-source domain adaptation dataset for text recognition, including five different domains with over five million images, which is the first multi-domain text recognition dataset to our best knowledge. Secondly, we propose a new method called Meta Self-Learning, which combines the self-learning method with the meta-learning paradigm and achieves a better recognition result under the scene of multi-domain adaptation. Thirdly, extensive experiments are conducted on the dataset to provide a benchmark and also show the effectiveness of our method. The code of our work and dataset are available soon at https://bupt-ai-cz.github. io/Meta-SelfLearning/.
Application Evaluation of High-Flow Humidified Oxygen in Patients with Respiratory Failure after General Anesthesia Extubation for Multiple Injuries

Objective To explore the effect of high-flow humidified oxygen therapy (HFNC) on patients with respiratory failure after general anesthesia extubation for multiple injuries. Methods 214 patients with multiple injuries in our hospital who underwent general anesthesia and suffered respiratory failure after weaning extubation and received sequential treatment were included. And, they were divided into control group (HFNC group) and observation group (NIMV group) according to the random number table method. Patients in the control group (125 cases) used high-flow nasal cannula (HFNC) after general anesthesia extubation, while patients in the observation group (89 cases) used NIMV. The respiratory rate, heart rate, finger pulse oxygen, oxygenation index (PaO2/FiO2), and re-tracheal intubation rate in the two groups were compared at 2, 8, and 24 hours after sequential treatment, and the mortality rate and hospital stay of ICU time were whole-course observation. And, the effect of conventional oxygen inhalation or HFNC on oxygenation and prognosis was analyzed. Then, SPSS21.0 software was applied for statistical analysis. To analyze the effect of conventional oxygen inhalation or HFNC on the improvement of oxygenation and prognosis, the receiver operating characteristic (ROC) curve can be used to evaluate the feasibility and treatment effect of high-flow nasal oxygen therapy (HFNC) for patients with respiratory failure after general anesthesia extubation for multiple injuries. Results Compared with the NIMV group, the respiratory frequency and heart rate of the HFNC group were significantly improved after 2 h, 8 h, and 24 h. At the same time, the finger pulse oxygen and oxygenation index increased significantly and returned to normal levels. HFNC can significantly reduce the reintubation rate, ICU hospital stay, and mortality rate. The area under the ROC curve was 0.9102, with 95% CI (0.8256, 0.9949) and P < 0.0001. Conclusion For patients with multiple injuries undergoing general anesthesia and respiratory failure after weaning and extubation, the application of HFNC can moderate patients' heart rate and respiratory rate faster, increase oxygenation index and finger pulse oxygen, and reduce the reintubation rate, mortality rate, and ICU stay. At the same time, it can effectively improve the respiratory failure of patients after extubation and reduce the occurrence of complications.
Effect of 8-week treadmill running with peroneal muscle functional electrical stimulation on laterally deviated centre of plantar pressure position and star excursion balance test performance

Introduction Ankle sprain is a common injury that can have long-term sequelae resulting in pain, swelling and a reduction of physical activity participation. Previous research has shown a laterally deviated centre of pressure (COP) during running gait increases the risk of lateral ankle sprain. As a method of altering COP, electrical stimulation has been considered. Method A group of 14 healthy males were randomly allocated to case control groups which were single blinded. The intervention involved an 8-week training programme of functional electrical stimulation to the peroneal muscles during treadmill running, with a sham control group. Outcomes were COP position and star excursion balance test. Statistical analysis was through SPSS using a combination of MANOVA, T-tests and Wilcoxon signed rank Results There was a significant difference in the results post intervention at max pressure for intervention M = 0.7(±0.7) and control M = −6.0 (±4.6) conditions; t(6) = −2.9, p < 0.05 Conclusion It has been demonstrated that FES can alter COP during max pressure in running gait after an 8-week training programme, although carry over effect appears limited and further testing is required.
On Some Mathematics Related to the Interpolating Statistics

Motivated by fractional quantum Hall effects, we introduce a universal space of statistics interpolating Bose-Einstein statistics and Fermi-Dirac statistics. We connect the interpolating statistics to umbral calculus and use it as a bridge to study the interpolation statistics by the principle maximum entropy by deformed entropy functions. On the one hand this connection makes it possible to relate fractional quantum Hall effects to many different mathematical objects, including formal group laws, complex bordism theory, complex genera, operads, counting trees, spectral curves in Eynard-Orantin topological recursions, etc. On the other hand, this also suggests to reexamine umbral calculus from the point of view of quantum mechanics and statistical mechanics.
A Rare Combination of Chromosomal Abnormalities in an Infant With Turner Syndrome and Hypoplastic Left Heart Syndrome

Hypoplastic left heart syndrome (HLHS) is a fatal congenital complex heart defect where the heart's left side is critically undeveloped. However, its pathogenesis remains unknown. We report a unique case of HLHS because of the rare combination of two abnormalities in the cell lines: partial monosomy X (Turner syndrome) and partial trisomy 14 (14q11.2 microduplication syndrome).
急性T淋巴细胞白血病患者NOTCH1/FBXW7基因突变与CDKN2A/B基因缺失的特点及对预后的影响

房秋云 1 郝其姗 1 弓晓媛 1 王君 1 李庆华 1 袁田 2 田征 1 刘凯奇 1 李艳 1 刘云涛 1 宫本法 1 王迎 1 魏辉 1 周春林 1 林冬 1 刘兵城 1 魏述宁 1 张广吉 1 王建祥 1 秘营昌 1 中国医学科学院血液病医院(中国医学科学院血液学研究所),实验血液学国家重点实 验室,国家血液系统疾病临床医学研究中心,天津 300020;天津医科大学肿瘤医院, 国家肿瘤临床医学研究中心,天津市“肿瘤防治”重点实验室,天津市恶性肿瘤临床医学 研究中心,天津市肿瘤免疫与生物治疗重点实验室 300060 通信作者:秘营昌,Email:ychmi@ihcams.ac. cn 基 金 项 目 :国 家 科 技 重 大 专 项(2017ZX09304024);天 津 市 自 然 科 学 基 金 (18JCYBJC91800);“十二五”国家科技支撑计划”(2014BAI09B12) DOI:10.3760/cma.j.issn.0253-2727.2021. 05.015
Dutch Mental Health Patients’ and Significant Others’ Perspectives on Compulsory Treatment at Home: One Size Does Not Fit All

On January 1, 2020, the Compulsory Mental Health Care Act took effect in the Netherlands. It contains provisions for compulsory community treatment (CCT) and compulsory treatment at home (CTH). In this study, we collected the opinions of patients and their significant others on CTH and on their preferences regarding compulsory care in their homes. Patients and their significant others were involved in the experience-based co-design of a purpose-built online questionnaire. This questionnaire was completed by 624 patients and 531 significant others. Sixty-one percent of the patients and 62% of the significant others did not want compulsory treatment to take place at home but in hospital or elsewhere. Patients’ and significant others’ opinion showed few differences, except with regard to the involvement of the significant others in CTH. As the respective views of patients and significant others were mixed, we recommend that crisis plans and compulsory treatment plans should be individually tailored to the needs and wishes of patients and their significant others regarding CTH.
Relation Extraction from Tables using Artificially Generated Metadata

Relation Extraction (RE) from tables is the task of identifying relations between pairs of columns of a table. Generally, RE models for this task require labelled tables for training. These labelled tables can also be generated artificially from a Knowledge Graph (KG), which makes the cost to acquire them much lower in comparison to manual annotations. However, unlike real tables, these synthetic tables lack associated metadata, such as, column-headers, captions, etc; this is because synthetic tables are created out of KGs that do not store such metadata. Meanwhile, previous works have shown that metadata is important for accurate RE from tables. To address this issue, we propose methods to artificially create some of this metadata for synthetic tables. Afterward, we experiment with a BERT-based model, in line with recently published works, that takes as input a combination of proposed artificial metadata and table content. Our empirical results show that this leads to an improvement of 9\%-45\% in F1 score, in absolute terms, over 2 tabular datasets.
Black Scoter habitat use along the southeastern coast of the United States

Abstract While the Atlantic Coast of the United States and Canada is a major wintering area for sea ducks, knowledge about their wintering habitat use is relatively limited. Black Scoters have a broad wintering distribution and are the only open water species of sea duck that is abundant along the southeastern coast of the United States. Our study identified variables that affected Black Scoter (Melanitta americana) distribution and abundance in the Atlantic Ocean along the southeastern coast of the United States. We used aerial survey data from 2009 to 2012 provided by the United States Fish and Wildlife Service to identify variables that influenced Black Scoter distribution. We used indicator variable selection to evaluate relationships between Black Scoter habitat use and a variety of broad‐ and fine‐scale oceanographic and weather variables. Average time between waves, ocean floor slope, and the interaction of bathymetry and distance to shore had the strongest association with southeastern Black Scoter distribution.
Nitrite as a causal factor for nitrate‐dependent anaerobic corrosion of metallic iron induced by Prolixibacter strains

Microbially influenced corrosion (MIC) may contribute significantly to overall corrosion risks, especially in the gas and petroleum industries. In this study, we isolated four Prolixibacter strains, which belong to the phylum Bacteroidetes, and examined their nitrate respiration‐ and Fe0‐corroding activities, together with two previously isolated Prolixibacter strains. Four of the six Prolixibacter strains reduced nitrate under anaerobic conditions, while the other two strains did not. The anaerobic growth of the four nitrate‐reducing strains was enhanced by nitrate, which was not observed in the two strains unable to reduce nitrate. When the nitrate‐reducing strains were grown anaerobically in the presence of Fe0 or carbon steel, the corrosion of the materials was enhanced by more than 20‐fold compared to that in aseptic controls. This enhancement was not observed in cultures of the strains unable to reduce nitrate. The oxidation of Fe0 in the anaerobic cultures of nitrate‐reducing strains occurred concomitantly with the formation of nitrite. Since nitrite chemically oxidized Fe0 under anaerobic and aseptic conditions, the corrosion of Fe0‐ and carbon steel by the nitrate‐reducing Prolixibacter strains was deduced to be mainly enhanced via the biological reduction of nitrate to nitrite, followed by the chemical oxidation of Fe0 to Fe2+ and Fe3+ coupled to the reduction of nitrite.
STAT3基因突变的T细胞大颗粒淋巴细胞白血病临床特征研究

目的 探讨携带STAT3基因突变的T细胞大颗粒淋巴细胞白血病（T-LGLL）患者的临床特征，为此类患者的临床管理提供参考。 方法 回顾性分析2009至2019年就诊于江苏省人民医院的T-LGLL患者的临床资料，比较STAT3突变患者与未突变患者的基线临床数据、治疗反应及生存结局。 结果 共纳入80例患者，STAT3未突变组66例，STAT3突变组14例（17.5％），其中Y640F突变发生频率最高（42.9％）。 STAT3突变组与STAT3未突变组相比，HGB减低（67.5 g/L对82. 5 g/L，P＝0.018），中性粒细胞计数减少（0.665×109/L对1. 465×109/L，P<0.001），乳酸脱氢酶升高（229 U/L对198 U/L，P＝0.041），铁蛋白升高（402.5 g/L对236. 0 g/L，P＝0.029），TCR Vβ亚家族表达率升高（89.2％对65. 4％，P＝0.014），具备治疗指征患者比例升高（100％对74％，P＝0.033）。 STAT3突变组与未突变组一线免疫抑制治疗的完全缓解率分别为38. 5％和32. 7％，差异无统计学意义（P＝0.748）。 STAT3突变组与未突变组一线免疫抑制治疗的总有效率分别为69. 2％和69. 4％，差异无统计学意义（P＝1.000）。 中位随访63（2～121）个月，两组总生存时间（均未达到）的差异无统计学意义（P＝0.170）。 结论 STAT3基因突变的T-LGLL患者可能有更高的肿瘤负荷和治疗需求，一线应用免疫抑制剂疗效良好。 STAT3基因突变对T-LGLL患者预后的意义尚需进一步验证。
The complete chloroplast genome of Cotyledon tomentosa Harv.

Abstract Cotyledon tomentosa Harv. is a well-known succulent plant that have important ornamental and economic value. In this study, we release and detail the complete chloroplast genome sequences of C. tomentosa. The whole chloroplast genome was 149,729 bp in length and comprised 131 genes, including 84 protein-coding genes, 37 tRNA genes, eight rRNA genes. The C. tomentosa. chloroplast genome had a GC content of 38.23%. Phylogenetic analysis based on the complete chloroplast genomes showed that C. tomentosa had a close relationship with Kalanchoe tomentosa, Bryophyllum daigremontianum and Kalanchoe fedtschenkoi.
The complete plastid genome of cherry plants Prunus sargentii (Rosaceae) and its phylogenetic implication

Abstract Prunus sargentii is an ornamental flowering cherry species, spread in Japan, Korea, Russia, and Northeast China. Little information is available regarding its genomic, with limited phylogenetic relationship study performed on P. sargentii until now. In this research, we reported the complete plastid genome of P. sargentii. The complete chloroplast of this species is 158,138 bp in length, including a pair of invert repeat regions (IR) (26,463bp) that is divided by a large single-copy region (LSC) (85,959bp) and a small single-copy region (SSC) (19,253bp). The plastid genome contained a total of 128 genes, including 84 coding genes, eight rRNA genes, and 36 tRNA genes. Phylogenetic analysis indicates that P. sargentii has a closer relationship with P. kumanoensis.
腺相关病毒基因修饰后间充质干细胞来源的外泌体免疫调节功能的研究

目的 验证天然状态间充质干细胞来源的外泌体（MSC-exosome）治疗小鼠急性移植物抗宿主病（GVHD）的效果和可能机制，探索并建立定向基因修饰MSC-exosome的方法并验证修饰后MSC-exosome的功能。 方法 构建小鼠急性GVHD模型，观察比较不同剂量MSC-exosome组和MSC组的生理指标评分、生存和体重减低程度；进而通过体外T细胞活化实验和体内OVA抗原特异性T细胞活化实验检测比较组间活化T细胞的增殖水平。 构建重组表达载体，获得携带PD-L1和PD-L1-ITGB1的AAV2YF3突变体，进而感染人MSC，分离获得其外泌体。 检测比较天然状态和修饰后MSC-exosome在体外和体内对活化T细胞的增殖水平和调节性T细胞（Treg）比例的影响。 结果 ①MSC-exosome（300 µg×3次）和小鼠MSC（1×106×3次）均能够有效改善急性GVHD小鼠的生理指标评分、生存和体重减低程度。 ②相比IL-2对照组，10、25、50 µg人MSC-exosome和1×106人MSC体外共孵育处理均能够抑制活化T细胞的增殖，增殖比例分别为86. 0％（IL-2）、40.0％、39.6％、42.8％和41. 0％；相比PBS对照组，50、100、200 µg小鼠MSC-exosome和1×106小鼠MSC在体内均能够抑制抗原特异性活化的OT-1细胞的增殖，增殖比例分别为42. 6％、33.1％、14.2％、10.6％和14. 6％。 ③携带PD-L1和PD-L1-ITGB1的AAV2YF3突变体定向修饰人MSC-exosome的表达率分别超过40％和60％。 ④相比天然状态，PD-L1和PD-L1-ITGB1定向修饰后MSC-exosome在体内对抗原特异性活化的OT-1细胞具有更好的增殖抑制效果；在体外亦能明显抑制活化T细胞的增殖，并诱导提高Treg的比例。 结论 MSC-exosome具有与MSC相似的免疫调节作用。 经过PD-L1和PD-L1-ITGB1修饰后的MSC-exosome能够有效抑制活化T细胞的增殖，并且能够诱导提高Treg的比例。
Short-Term Subcutaneous Allergy Immunotherapy and Dupilumab are Well Tolerated in Allergic Rhinitis: A Randomized Trial

Background Subcutaneous immunotherapy (SCIT) has been proven as an effective therapy against some allergens for seasonal allergic rhinitis (SAR) patients unresponsive to intranasal corticosteroids and/or antihistamines but carries risk of systemic allergic reactions. Dupilumab blocks the shared receptor component for interleukin-4 and interleukin-13, key and central drivers of type 2 inflammation in multiple diseases. Objective To evaluate the efficacy and safety of SCIT+dupilumab vs SCIT alone. Methods This phase 2a, multicenter, double-blind, placebo-controlled parallel-group study conducted in 103 adults with grass pollen-induced SAR (NCT03558997) randomized patients 1:1:1:1 to SCIT, dupilumab (300 mg every 2 weeks), SCIT+dupilumab, or placebo. SCIT was administered using an 8-week cluster protocol followed by 8 weeks of maintenance injections. Primary endpoint was change from pre-treatment baseline in area under the curve (AUC) in total nasal symptom score (TNSS) 0–1 h following nasal allergen challenge (NAC) with timothy grass extract at Week 17. Results Although 16 weeks of treatment with SCIT+dupilumab did not significantly improve TNSS AUC (0–1 h) following NAC at Week 17 vs SCIT (least squares mean −56.76% vs −52.03%), a higher proportion of SCIT+dupilumab-treated patients (61.5%) achieved SCIT maintenance dose vs SCIT (46.2%). A lower proportion of SCIT+dupilumab-treated patients (7.7%) required epinephrine rescue treatment vs SCIT (19.2%). There were significantly fewer withdrawals in the SCIT+dupilumab group than in the SCIT group (n = 2 [7.7%] vs n = 8 [30.8%]; P = 0.0216); the majority of SCIT group withdrawals were due to SCIT-related intolerability, compared with no discontinuations from the SCIT+dupilumab group. Conclusion In SAR patients, 16 weeks of SCIT+dupilumab may improve SCIT tolerability but did not incrementally reduce post-allergen challenge nasal symptoms compared with SCIT alone. Clinical Study Number NCT03558997.
Analysis of the complete chloroplast genomes of Scutellaria tsinyunensis and Scutellaria tuberifera (Lamiaceae)

Abstract Scutellaria Linn. is a perennial herb with about 300 species. This genus has high medicinal value and many are used in Traditional Chinese Medicine (TCM). In this study, we sequenced and assembled the complete chloroplast genomes of Scutellaria tsinyunensis and S. tuberifera. Subsequently, we conducted a comprehensive comparative genomics analysis with 12 other published Scutellaria species. These genomes all had a conserved quartile structure, and the gene contents, gene sequences and GC contents are highly similar. The study on the genetic characteristics and nucleotide substitution rate of different genes found that the protein-coding genes of chloroplasts have differed greatly. Most genes are under purifying selection, but the rps12 gene may have undergone positive selection. Besides, we identified three hypervariable regions as potential markers for Scutellaria taxa, which could play an important role in species identification of Scutellaria. Phylogenetic analysis showed that the 14 Scutellaria taxa were divided into two major clades. Moreover, the variation of IR regions is closely related to the evolutionary history as was reconstructed based on SNPs. In conclusion, we provided two high-quality chloroplast reference genomes of Scutellaria, this reliable information and genomic resources are valuable for developing of efficient DNA barcodes as reconstruction of chloroplast evolutionary history of the genus.
Clostridioides difficile Ribotype 027 (RT027) Outbreak Investigation Due to the Emergence of Rifampicin Resistance Using Multilocus Variable-Number Tandem Repeat Analysis (MLVA)

Objective The aim of this study was Clostridioides difficile outbreak investigation due to the emergence of rifampicin resistant ribotype 027 (RT 027) fecal isolates from patients of Polish tertiary care hospital between X. 2017 and II. 2018 using multilocus variable tandem repeat analysis (MLVA). Materials and Methods Twenty-nine C. difficile fecal isolates from patients of tertiary care hospital in Southern Poland were ribotyped and analyzed by MLVA. Multiplex PCR (mPCR) for genes encoding GDH (gluD), toxins A (tcdA)/ B (tcdB), 16S rDNA and binary toxin genes (ctdA and ctdB) was performed. The antibiotic susceptibility profile was determined by E-test. Results The A, B and binary toxins encoding genes were detected in all 29 C. difficile strains which were sensitive to metronidazole, vancomycin and were resistant to erythromycin, clindamycin, and moxifloxacin; resistance to imipenem demonstrated 97%, to rifampicin – 45% isolates. C. difficile strains could be grouped by MLVA into 5 distinct clusters, and the largest cluster II contains 16 strains. The comparison of rifampicin GM MIC of cluster II (n=16 strains) with all others (n=13) showed that strains from clusters I, III, IV and V possessed significantly (p <0.005) higher GM MIC and were more resistant to rifampicin. Conclusion MLVA analysis proved transmission and recognized outbreak due to multidrug-resistant RT 027 C. difficile among patients of tertiary care hospital in Southern Poland. The reason for this is probably the widespread occurrence of spores in the hospital environment, which includes, among others, neglect of hygienic procedures and epidemic supervision. High resistance to imipenem (97%) and to rifampicin (45%) among C. difficile RT 027 Silesian isolates is threatening and requires further studies to elucidate this phenomenon.