Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk prediction for Obstructive Sleep Apnea prognostic in Obese patients referred for bariatric surgery

ABSTRACT Objectives (i) To assess the anthropometric measurements, along with the clinical characteristics and quality of life profiles of the studied patients; (ii) To determine the occurrence and severity of Obstructive Sleep Apnea (OSA), using polysomnography; and (iii) To identify the best anthropometric and clinical indicators to predict OSA in obese patients who are candidates for bariatric surgery. Methods a prospective observational study conducted in a private clinic, using consecutive sampling of patients eligible for bariatric surgery with a BMI ≥ 40, or with a BMI of ≥ 35 kg/m² accompanied by comorbidities associated with obesity. Results Sixty patients were initially selected, of whom 46 agreed to take part in the preoperative evaluation. OSA was observed in 76% of patients, 59% of whom had moderate-to-severe OSA, with a predominance of men in these groups. Among the variables suggesting statistical difference between groups, waist-to-hip ratio (WHR) was the only clinical factor associated with scores the apnea hypopnea index (AHI) ≥ 15, with a cut-off value of 0.95. The results showed that patients scoring above 0.95 are three times more likely to have moderate-to-severe apnea. Conclusion The best risk factor for the prognostic of moderate-to-severe OSA was presenting a WHR score with a cut-off value of 0.95 or above.
A REVIEW OF KNOWLEDGE GRAPH AND GRAPH NEURAL NETWORK APPLICATION

: Many learning activities include working with graph data, which offers a wealth of relational information between parts. Modeling physical systems, learning molecular fingerprints, predicting protein interfaces, and diagnosing illnesses all need the use of a model that can learn from graph inputs. In other fields, such as learning from non-structural data such as texts and images, reasoning on extracted structures (such as phrase dependency trees and image scene graphs) is a major topic that requires graph reasoning models. Graph neural networks (GNNs) are neural models that use message transmission between graph nodes to represent graph dependency. Variants of GNNs have recently showed ground-breaking performance on a variety of deep learning tasks. This paper represents a review of the literature on Knowledge Graphs and Graph Neural Networks, with a particular focus on Graph Embeddings and Graph Neural Networks applications as a powerful tool for organizing structured data and making sense of unstructured data, which can be applied to a variety of real-world problems.
Current situation of shared decision making in osteoporosis: A comprehensive literature review of patient decision aids and decision drivers

Osteoporosis is a systemic skeletal disease characterized by low bone mass and microstructural deterioration of bone tissues, resulting in bone fragility and increased fracture risk. It is the most common bone‐related disease in the population. However, the proportion of patients who start treatment but discontinue it during the first year is very high (around 50%). Endeavors are made to promote patient participation in treatment by implementing patient decision aids (PDA), whose function is to help the patient make disease‐related decisions. We aim to summarize the characteristics of the currently available PDA for osteoporosis, as well as deciding factors.
The Impact of a Yoga-Based Mindfulness Intervention versus Psycho-Educational Session for Older Adults with Mild Cognitive Impairment: The Protocol of a Randomized Controlled Trial

Background: There is a global agreement in the medical community that a significant proportion of dementia cases could be prevented or postponed. One of the factors behind this agreement comes from scientific evidence showing that mind-body interventions such as mindfulness and yoga for the elderly have been related to a range of positive outcomes, including improved cognition performance in seniors with mild cognitive impairment (MCI). Objective: This study aims to evaluate the effectiveness of a yoga-based mindfulness intervention (YBM) versus psychoeducational sessions for older adults with MCI attending Hospital Clinic Universidad de Chile in Santiago. Method: Two-arm, individually randomized controlled trial (RCT) will be carried out at Clinical Hospital Universidad de Chile in Santiago. Older people over 60 years with any type of MCI using a score < 21 in the Montreal Cognitive Assessment (MoCA) test and a score of 0.05 in the Clinical Dementia Rating (CDR) Scale; and with preserved activities of daily living will be randomly assigned with an allocation ratio of 1:1 in either the yoga-based mindfulness intervention or the active control group based on the psycho-educational program. People who have performed yoga and/or mindfulness in the last 6 months or/and people with a psychiatric clinical diagnosis will be excluded from the study. Montreal Cognitive Assessment, the Lawton Instrumental Activities of Daily Living Scale (IADL), the Barthel Index (BI), the Pemberton happiness index, the Geriatric Anxiety Inventory (GAI) as well as the Geriatric Depression Scale (GDS-5) will be administered by blinded outcomes assessors before random assignment (Pre-test), the week following the last session of the intervention (post-test), and then after 3- and 6-months follow-up. Results: The YBM intervention protocol based on a video recording has been adapted and designed. This is the first RCT to examine the effects of a yoga-based mindfulness intervention in improving cognitive and physical functions and mental health outcomes for Chilean elderly diagnosed with MCI. It is expected to be implemented as an acceptable and effective non-pharmacological option for older people with MCI. Conclusion: Providing evidence-based programs such as preventive therapy for Alzheimer’s disease has relevant implications for public mental health services in Chile.
Animal models for the study of intracranial hematomas (Review)

Intracranial hematomas (ICH) are a frequent condition in neurosurgical and neurological practices, with several mechanisms of primary and secondary injury. Experimental research has been fundamental for the understanding of the pathophysiology implicated with ICH and the development of therapeutic interventions. To date, a variety of different animal approaches have been described that consider, for example, the ICH evolutive phase, molecular implications and hemodynamic changes. Therefore, choosing a test protocol should consider the scope of each particular study. The present review summarized investigational protocols in experimental research on the subject of ICH. With this subject, injection of autologous blood or bacterial collagenase, inflation of intracranial balloon and avulsion of cerebral vessels were the models identified. Rodents (mice) and swine were the most frequent species used. These different models allowed improvements on the understanding of intracranial hypertension establishment, neuroinflammation, immunology, brain hemodynamics and served to the development of therapeutic strategies.
Filli Café: Experience Tea and Talk

Filli Café in the United Arab Emirates (UAE) has captured a slice of the market with the unique taste of zafran tea. This was superimposed by applying a unique branding strategy. The brand’s unique selling proposition was to create a homely ambience at Filli Café, where people could chat for hours while immersed in the joy of a warm, soothing cup of tea. This led to the brand’s huge success, with the target audience being the expatriates and Emirati population, as they liked the taste of the zafran tea. The challenge in front of the Chief Executive Officer, Mr Rafih Filli, was to grab the market and work on diversification and expansion globally.
Ion-dose-dependent microstructure in amorphous Ge

Implantation-induced, microstructural modifications including increased bond length and non-Gaussian static disorder have been measured in amorphous Ge using extended x-ray absorption fine-structure spectroscopy. The evolution of the amorphous phase interatomic distance distribution as functions of ion dose and implant temperature demonstrates the influence of implantation conditions on amorphous phase structure. Results are attributed to increased fractions of three- and fivefold coordinated atoms as a means of accommodating implantation-induced point defects. (c) 2000 The American Physical Society.
An Alliance of Carbapenem-Resistant Klebsiella pneumoniae with Precise Capsular Serotypes and Clinical Determinants: A Disquietude in Hospital Setting

Carbapenemase-resistant Klebsiella pneumoniae (CRKP) is a genuine burden for physicians and researchers. We aimed at carbapenemase resistance and its relation with capsular serotyping in K. pneumoniae and studied some clinical determinants, which may influence the clinical infections. Initially, 61 K. pneumoniae isolates obtained from various clinical specimens were confirmed at the molecular level and then antimicrobial susceptibility test was performed followed by capsular serotyping performed by multiplex PCR. All isolates were subjected to the detection of carbapenemase genes including blaKPC, blaNDM-1, blaOXA-48, blaVIM, and blaIMP. Clinical and demographic data of all patients were reviewed including age, gender, underlying diseases, and the treatment obtained. Multidrug-resistance was a predominant feature in 77% K. pneumoniae strains. Presence of extended-spectrum beta-lactamase was detected phenotypically in 59% K. pneumoniae strains. Carbapenem resistance was noticed phenotypically in 24.6% isolates. blaOXA-48 and blaNDM-1 were the most frequent carbapenemase genes. blaNDM-1 positive isolates correlated with gentamicin, amikacin, imipenem, and meropenem resistance (p < 0.05). The nosocomial isolates mostly harbored blaOXA-48 gene (p < 0.02). Amongst all the K. pneumoniae isolates, 59% isolates could be typed and serotype K54 had the highest prevalence followed by K20 and K5. Correlation between the carbapenemase genes, serotype and type of infection showed that blaOXA-48 positive strains had a significant association with K20 serotype and urinary tract infections (p=0.2) while, K20 serotype and blaKPC positive strains were significantly associated with wound infections (K20, p=0.3 and blaKPC, and p=0.4). Mucoid phenotype was not found related to presence of specific carbapenemase genes or serotypes except serotype K20 (p < 0.001). Patients with monotherapy had treatment failure in comparison to the combination therapy for blaKPC-associated infections. In conclusion, the present investigation exhibited the significant association between K20 serotype with blaOXA-48. The predominance of K54 reveals the possibility of endemicity in our hospital setting. K. pneumoniae isolated from wound specimens significantly harbors K20 serotype and blaKPC gene. Comprehensive clinical information and the distribution of antibiotic resistance genes, and serotypes may play important roles in the treatment process.
Exchangeable interval hypergraphs and limits of ordered discrete structures

A hypergraph $(V,E)$ is called an interval hypergraph if there exists a linear order $l$ on $V$ such that every edge $e\in E$ is an interval w.r. t. $l$; we also assume that $\{j\}\in E$ for every $j\in V$. Our main result is a de Finetti-type representation of random exchangeable interval hypergraphs on $\mathbb{N}$ (EIHs): the law of every EIH can be obtained by sampling from some random compact subset $K$ of the triangle $\{(x,y):0\leq x\leq y\leq 1\}$ at iid uniform positions $U_1,U_2,\dots$, in the sense that, restricted to the node set $[n]:=\{1,\dots,n\}$ every non-singleton edge is of the form $e=\{i\in[n]:x<U_i<y\}$ for some $(x,y)\in K$. We obtain this result via the study of a related class of stochastic objects: erased-interval processes (EIPs). These are certain transient Markov chains $(I_n,\eta_n)_{n\in\mathbb{N}}$ such that $I_n$ is an interval hypergraph on $V=[n]$ w.r. t. the usual linear order (called interval system). We present an almost sure representation result for EIPs. Attached to each transient Markov chain is the notion of Martin boundary. The points in the boundary attached to EIPs can be seen as limits of growing interval systems. We obtain a one-to-one correspondence between these limits and compact subsets $K$ of the triangle with $(x,x)\in K$ for all $x\in[0,1]$. Interval hypergraphs are a generalizations of hierarchies and as a consequence we obtain a representation result for exchangeable hierarchies, which is close to a result of Forman, Haulk and Pitman. Several ordered discrete structures can be seen as interval systems with additional properties, i.e. Schr\"oder trees and binary trees. We describe limits of Schr\"oder trees as certain tree-like compact sets. Considering binary trees we thus obtain a homeomorphic description of the Martin boundary of R\'emy's tree growth chain, which has been analyzed by Evans, Gr\"ubel and Wakolbinger.
The Role of IL-6 in Cancer Cell Invasiveness and Metastasis—Overview and Therapeutic Opportunities

Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, inflammation, and immunity, including COVID-19. In this review, we summarise the role of IL-6 signalling pathways in cancer biology, with particular emphasis on cancer cell invasiveness and metastasis formation. Targeting principal components of IL-6 signalling (e.g., IL-6Rs, gp130, STAT3, NF-κB) is an intensively studied approach in preclinical cancer research. It is of significant translational potential; numerous studies strongly imply the remarkable potential of IL-6 signalling inhibitors, especially in metastasis suppression.
Evaluation of the efficiency of color traps and some insecticides in the population density of green peach Myzus persicae Sulzer on tomato plant

This study aims to study the population density of the Peach Aphid Myzus persicae Sulzer and compared the efficiency of color traps with some insecticides Acetampride (ACelan 20% SL), Imidacloprid (Confidor 20% SL), Tiamethoxam (Actara 25 WG) and cold aqueous extract of Azadirachta indica seeds and Ricinus communis seeds in the insect control, The study was conducted in the Ishaqi city, Salahedin Governorate famous which known the cultivation of tomato Soalnum lycopersicum.The highest average of insects caught during May 2020 was 85.42 adult/plant, while the lowest insects reached 12.50 adult/plant during March 2020 in the first site while the highest average of insects caught during May reached 86.21 adult/plant, while the lowest rate was 22.35 adult/plant during the March in the second site This study show that the yellow color more attractive colors than white and red and shows that the red color less attractive colors. The highest mortality rate of acetampride was 92.3% after 24 h of treatment ,while the highest mortality rate of thiamethoxam and amidacloprid was 85.65% and 55.52%, respectively, after 24 h of treatment.The results showed the effect of cold water extracts on mortality of M . persicae Sulzer was 67.42% for the A.indica seeds, while the mortality rate was 78.59% for the R . communis, after 24 h, highest mortality rate of acetambride was 87.1% after 72 h of treatment, while highest mortality of thiamethoxam and amidacloprid was 71.3% and 49.2%, respectively, after 72 h of treatment. The results showed the effect of cold water extracts on mortality of M. persicae Sulzer, causes a mortality rate of 45.23% for the cold water extra of A . indica , while the mortality rate was 58.46% for the cold water extracts of castor plant R . communis after 72 h of treatment.
Crossed products by minimal homeomorphisms

Abstract Let X be an infinite compact metric space with finite covering dimension and let h : X → X be a minimal homeomorphism. We show that the associated crossed product C*-algebra A = C*(ℤ, X, h) has tracial rank zero whenever the image of K 0(A) in Aff(T(A)) is dense. As a consequence, we show that these crossed product C*-algebras are in fact simple AH algebras with real rank zero. When X is connected and h is further assumed to be uniquely ergodic, then the above happens if and only if the rotation number associated to h has irrational values. By applying the classification result for nuclear simple C*-algebras with tracial rank zero, we show that two such dynamical systems have isomorphic crossed products if and only if they have isomorphic scaled ordered K-theory.
Centers of KLR algebras and cohomology rings of quiver varieties

Attached to a weight space in an integrable highest weight representation of a simply-laced Kac-Moody algebra $\mathfrak{g}$, there are two natural commutative algebras: the cohomology ring of a quiver variety and the center of a cyclotomic KLR algebra. In this note, we describe a natural geometric map between these algebras in terms of quantum coherent sheaves on quiver varieties. The cohomology ring of an algebraic symplectic variety can be interpreted as the Hochschild cohomology of a quantization of this variety in the sense of Bezrukavnikov and Kaledin. On the other hand, cyclotomic KLR algebras appear as Ext-algebras of certain particular sheaves, and thus its center receives a canonical map from the Hochschild cohomology of the category. We show that this map is an isomorphism in finite type, and injective in general. We further note that the Kirwan surjectivity theorem for quivers of finite type is an easy corollary of these results. The most important property of this map is its compatibility with actions of the current algebra on both the cohomology of quiver varieties and on the Hochschild cohomology of any category with a categorical action of $\mathfrak{g}$. The structure of these current algebra actions allow us to show the desired results.
Galactomannan and Alginate Double Coat Encapsulation of Sulfamethoxazole-Trimethoprim for Treatment for Controlled Intestinal- Targeted Drug Delivery

Intracellular bacterial infections cause diseases that are hard to treat because of the anatomical barriers before the antibiotic reaches the target site and small intestine for absorption. Thus, the modulated release of the antibiotic with higher stability and drug retention needs to be achieved. Encapsulation using polymers retains the stability of drugs from the harsh environment of the stomach and delivers a drug to its intended site of release. This study aims to assess the drug release property and stability of galactomannan and alginate double coat encapsulation of SMX-TMP. The encapsulation of SMX-TMP using biopolymers was done through the extrusion method. The stability of the capsule was subjected to in vitro gastrointestinal simulation analysis and was analyzed using Fourier transform infrared spectrometer (FTIR) and scanning electron microscope (SEM) to confirm the successful encapsulation and its surface morphology. The delivery of the active drug, SMX-TMP, from the capsule was observed without significant degradation in the simulated gastric environment and disintegrates at the fasted state (pH 8) of the simulated intestinal environment, which is the target site of drug release. In vitro stability test validates the protection of SMX-TMP (encapsulated) from the gastrointestinal tract (GIT) conditions. The fingerprint of drug and encapsulating material was found to be present after drug encapsulation and intestinal disintegration. Morphological micrographs showed that the capsules were spherical that measures approximately 2.7 mm; ridges at the surface of the microcapsules were present for quick hydration and disintegration. This study reports the potential of galactomannan and alginate as candidates for encapsulating antibiotics for modulated and targeted drug delivery
Cellular UAV-to-UAV Communications

Reliable and direct communication between unmanned aerial vehicles (UAVs) could facilitate autonomous flight, collision avoidance, and cooperation in UAV swarms. In this paper, we consider UAV-to-UAV (U2U) communications underlaying a cellular network, where UAV transmit-receive pairs share the same spectrum with the uplink (UL) of cellular ground users (GUEs). We evaluate the performance of this setup through an analytical framework that embraces realistic height-dependent channel models, antenna patterns, and practical power control mechanisms. Our results demonstrate that, although the presence of U2U communications may worsen the performance of the GUEs, such effect is limited as base stations receive UAV interference through their antenna sidelobes. Moreover, we illustrate that the quality of all links degrades as the UAV height increases— due to a larger number of line-of-sight interferers—, and how the performance of the U2U links can be traded off against that of the GUEs by varying the UAV power control policy.
Role of Cervical Spinal Magnetic Stimulation in Improving Posture and Functional Ambulation of Patients with Relapsing Remitting Multiple Sclerosis

Balance impairment is one of the hallmarks of early MS. Proprioceptive deficit was found to be one of the main causes of this imbalance. The cervical enlargement has a strong proprioceptive system, with its projections to the reticular formation and the central pattern generators, helping in rhythmic pattern generation and alternate leg movements. Repetitive trans-spinal magnetic stimulation (rTSMS) is a noninvasive technique, which can trigger massive proprioceptive afferents. Therefore, it has the potential of improving proprioceptive deficits and motor control. Objective. To determine the effectiveness of repetitive cervical magnetic stimulation in improving functional ambulation of patients with relapsing remitting multiple sclerosis (RRMS). Design. Prospective sequential clinical trial. Setting. University and academic hospital. Participants. A total of 32 participants (N = 32) with RRMS. Interventions. Outpatient rehabilitation. The 32 patients received 10 sessions over two weeks of 20 Hz cervical spinal magnetic stimulation (SMS). Both groups were assessed at baseline, after 2 weeks, then one month later. Patients were enrolled as a control group at first and received Sham SMS, and then a wash out period of one month was done for all the patients, followed by a baseline assessment. Second, the same 32 patients rejoined as the active group, which received real magnetic stimulation. Both groups performed an intensive physical therapy program with the spinal magnetic stimulation. Main Outcome Measures. Extended Disability status score (EDSS), Timed up and Go test (TUG), Mini-Best test, dynamic posturography sensory organization composite score, and motor composite score. Results. Thirty-two RRMS patients with EDSS range from 1.5 to 6. They showed statistically significant difference between active and control groups in Mini-Best test score. We divided our patients according to EDSS into 3 subgroups: (a) mild: ≤2.5, (b) moderate: 3-5.5, and (c) severe: ≥6. Mild cases showed significant differences in EDSS score, TUG test, Mini-Best test, and dynamic posturography sensory composite scale. The effect size between the different patient subgroups was also measured and showed highly significant improvements in all measured parameters among our mild patients, indicating that this subgroup could be the best responders to cervical repetitive high-frequency magnetic stimulation. Moderate cases showed highly significant improvement in TUG score and Mini-Best test and significant change in EDSS score and the dynamic posturography sensory composite score. Severe cases showed only significant improvements in TUG, Mini-Best test, and sensory composite score. Conclusion. Cervical repetitive magnetic stimulation can help improve balance and functional ambulation and decreases the risk of falls in RRMS patients, especially in the mild, low disability cases.