Miracle-dz/UniFAR-FTUs huggingface dataset:
Qualitative and quantitative phytochemical evaluation of Quassia undulata (Guill. & Perr.) D. Dietr. leaves using different solvent polarities

This study investigated solvent effects on the phytochemical composition of Quassia undulata leaves a medicinal plant used in treating arrays of diseases including fever and cough. The leaves were collected, washed, air-dried, pulverized and evaluated for some inherent phytochemicals using four different solvent systems based on their polarities. The solvents are methanol, acetone, ethyl acetate and chloroform. The methanol extract was found to have the highest number of secondary metabolites (saponins, tannins, flavonoids, steroids, coumarins, anthraquinones, alkaloids and phenols). None of the extracts tested positive for the presence of phlobatannins, terpenoids and emodins. The methanol extract was further analyzed quantitatively for some of the determined phytochemicals. Tannins had a concentration of 3.131 mg of catechin equivalents per 100 mg sample (mg CE/100g), alkaloids-5.200 %, total phenolics-11.828 mg of gallic acid equivalents per gram of extract (mg GAE/g), flavonoids-8.074 mg of quercetin equivalents per gram of extract (mg QE/g) while 0.673 % saponins were detected. The presence of these secondary metabolites might justify the ethnomedicinal uses of Quassia undulata leaves as their bioactivity has been found to be dependent on the solvent used for extraction.
Role of Flaxseed Gum and Whey Protein Microparticles in Formulating Low-Fat Model Mayonnaises

Flaxseed gum (FG) and whey protein microparticles (WPMs) were used to substitute fats in model mayonnaises. WPMs were prepared by grinding the heat-set whey protein gel containing 10 mM CaCl2 into small particles (10–20 µm). Then, 3 × 4 low-fat model mayonnaises were prepared by varying FG (0.3, 0.6, 0.9 wt%) and WPM (0, 8, 16, 24 wt%) concentrations. The effect of the addition of FG and WPMs on rheology, instrumental texture and sensory texture and their correlations were investigated. The results showed that all samples exhibited shear thinning behavior and ‘weak gel’ properties. Although both FG and WPMs enhanced rheological (e.g., viscosity and storage modulus) and textural properties (e.g., hardness, consistency, adhesiveness, cohesiveness) and kinetic stability, this enhancement was dominated by FG. FG and WPMs affected bulk properties through different mechanisms, (i.e., active filler and entangled polysaccharide networks). Panellists evaluated sensory texture in three stages: extra-oral, intra-oral and after-feel. Likewise, FG dominated sensory texture of model mayonnaises. With increasing FG concentration, sensory scores for creaminess and mouth-coating increased, whereas those of firmness, fluidity and spreadability decreased. Creaminess had a linear negative correlation with firmness, fluidity and spreadability (R2 > 0.985), while it had a linear positive correlation with mouth-coating (R2 > 0.97). A linear positive correlation (R2 > 0.975) was established between creaminess and viscosity at different shear rates/instrumental texture parameters. This study highlights the synergistic role of FG and WPMs in developing low-fat mayonnaises.
Small Non-Coding RNAs in Leukemia

Simple Summary Leukemia is a group of blood cancers that arise when abnormal or underdeveloped blood cells accumulate in the bloodstream, bone marrow and lymphatic system. A driver event in the development of Chronic Lymphocytic Leukemia (CLL) is the deletion of the genomic region encoding for miR-15a/16-1. MicroRNAs are small non-coding RNAs involved in the regulation of gene expression, and loss of miR-15a/16-1 in CLL results in the accumulation of the antiapoptotic gene BCL2 and inhibition of the apoptotic process. This discovery was the first evidence that microRNAs have a role in the onset of cancer. Following this finding, several studies investigated the role of microRNAs and other small non-coding RNAs in different types of leukemia and cancers in general. This review summarizes the role of small non-coding RNAs in leukemia and describes their possible application in clinical settings as biomarkers and/or targets for therapy. Abstract In 2020, more than 60,500 people were diagnosed with leukemia in the USA, and more than 23,000 died. The incidence of leukemia is still rising, and drug resistance development is a serious concern for patients’ wellbeing and survival. In the past two decades, small non-coding RNAs have been studied to evaluate their functions and possible role in cancer pathogenesis. Small non-coding RNAs are short RNA molecules involved in several cellular processes by regulating the expression of genes. An increasing body of evidence collected by many independent studies shows that the expression of these molecules is tissue specific, and that their dysregulation alters the expression of genes involved in tumor development, progression and drug response. Indeed, small non-coding RNAs play a pivotal role in the onset, staging, relapse and drug response of hematological malignancies and cancers in general. These findings strongly suggest that small non-coding RNAs could function as biomarkers and possible targets for therapy. Thus, in this review, we summarize the regulatory mechanisms of small non-coding RNA expression in different types of leukemia and assess their potential clinical implications.
Study on steering of tracked vehicles on ramp

The necessity and important of studying the characteristics of ramp steering were described.According to the steering characteristics of tracked vehicle,a dynamic model of steering was established based on the analysis of steering condition on ramp.The calculating formulas of the offset of pressure center,the offset of instantaneous turning center,steering required braking force and traction pull with the change of the vehicle azimuth were deduced.Based on the formulas,the cause and rules of the offset of instantaneous turning center and tractive pull needed were analyzed.Meanwhile,the effects of different turning radius and the degree of slope upon steering stability were researched,in which the factors of causing steering instability were indicated.
XBRL, How It Implies The Audit Process?

: This article aimed to know what is XBRL, how it works and it implies to audit process. XBRL as a new tool was expected to produce a timelines, reliable, and credible financial reporting. With its real-time and interactive data, XBRL will help the investor, and other stakeholder in receiving, storing, analyzing the information quickly. While in audit profession, XBRL will speed up the audit process, save the audit cost and increase the revenue. However, in fact, XBRL will make it happen if it was implemented and integrated to an information system owned by data/information provider.
Comparative study between mechanical and chemical treatments for the preparation of nanocellulose

Nanocrystalline cellulose (NCC) is usually obtained by the acid hydrolysis of microcrystalline cellulose for its use as polymer reinforcement. An ecological alternative to this process, avoiding the use of acids, is a mechanical method. High intensity ultrasonication (HIU) in optimal conditions (time, wave amplitude, volume ratio fiber/solution, cellulose extraction source) can be applied to prepare nanofibrillated cellulose (NFC). In this work, the HIU method was used to mechanically prepare NFC. Ultrasonication time (t) and wave amplitude (A) were optimized seeking for NFC with high crystallinity, strong thermal stability, large aspect ratio (length to diameter) and large surface to volume ratio with diameter in nanometer scale. The morphology and the physical/chemical properties of the NFC prepared at optimal HIU conditions were compared with those of NCC prepared from the same cellulose source at optimal acid hydrolysis (AH) conditions. Similar purity, lower crystallinity, improved thermal stability and larger aspect ratio with diameter in nanoscale were obtained for NFC prepared by HIU. These results can be used as an initial screening for the selection of the optimal process for NCC manufacture focusing on their use as polymer reinforcement.
Effect of Graphite Filler Type on the Thermal Conductivity and Mechanical Behavior of Polysulfone-Based Composites

The goal of this study was to create a high-filled composite material based on polysulfone using various graphite materials. Composite material based on graphite-filled polysulfone was prepared using a solution method which allows the achievement of a high content of fillers up to 70 wt. %. Alongside the analysis of the morphology and structure, the thermal conductivity and mechanical properties of the composites obtained were studied. Structural analysis shows how the type of filler affects the structure of the composites with the appearance of pores in all samples which also has a noticeable effect on composites’ properties. In terms of thermal conductivity, the results show that using natural graphite as a filler gives the best results in thermal conductivity compared to artificial and expanded graphite, with the reduction of thermal conductivity while increasing temperature. Flexural tests show that using artificial graphite as a filler gives the composite material the best mechanical load transfer compared to natural or expanded graphite.
Does renewable mean good for climate? Biogenic carbon in climate impact assessments of biomass utilization

Using biomass to substitute fossil resources is seen as one of the sustainable ways to tackle climate change. Yet not all biomass projects can be a priori declared beneficial. A climate impact assessment, such as life cycle assessment or carbon footprint, is crucial for a science‐based policy recommendation. However, those assessments can often be incomplete, especially since many of those adopt an assumption that biogenic CO2 emissions cause no harm to the climate and do not need to be accounted. Such a simplistic “neutrality assumption” can lead to inaccurate results and thus to undesired consequences. This article synthesizes and further develops the diverse argumentation against the “neutrality assumption,” especially regarding the complexity of biomass production, differences in the timing of emission, allocation procedure, and climate change characterization methodology. Thus, the article draws a broader picture of the complex issue of biomass projects and argues for more comprehensive assessments.
A Comparative Study of the Fama-French Three Factor and the Carhart Four Factor Models: Empirical Evidence from Morocco

This paper investigates the validity of the Fama-French Three Factor (FF3F) and the Carhart Four Factor (C4F) models in Morocco. Monthly returns of Casablanca Stock Exchange-listed companies are extracted from Reuters DATASTREAM over a 5 years’ period (2013-2017). Market, size, value and momentum effect-mimicking exogenous variables are formed and regressed against the returns of size and value-sorted portfolios over a total of 8 multivariate linear regressions. While the size and value effects were found to partially hold, the momentum effect was found to be insignificant. Additionally, the C4F Model did not exhibit a better explanatory power compared to the FF3F Model. It appears that both models cannot be fully relied on in order to predict cross-sections of return in the Casablanca Stock Exchange (CSE), as they both only partially hold in the latter. Ultimately, this study brings value to the existing literature by testing two widely explored asset pricing models in an emerging market where equity research-oriented inquiries are relatively scarce or basic. Even if the models do not fully hold in the Moroccan context, this study posits whether the individual anomalistic factors hold in the CSE, which might be useful for future asset pricing models augmenting endeavors.
Molecular Determinants of Ethionamide Resistance in Clinical Isolates of Mycobacterium tuberculosis

Background: Ethionamide and prothionamide are now included in group C of the WHO recommended drugs for the treatment of tuberculosis resistant to rifampicin and multidrug-resistant tuberculosis. The clinical relevance of ethionamide and prothionamide has increased with the wide spread of resistant tuberculosis. Methods: We retrospectively analyzed 349 clinical isolates obtained between 2016 and 2020. The susceptibility to ethionamide was tested using both the BactecTM MGITTM 960 system and the SensititreTM MYCOTB plate. Results: The MIC of ethionamide increases with the total resistance of the isolates in a row from susceptible to XDR strains. A significant part of the isolates have a MIC below the breakpoint: 25%, 36%, and 50% for XDR, pre-XDR, and MDR strains. Sensitivity and specificity of detection of mutations were 96% and 86% using MGIT resistance as a reference. Conclusions: Phenotypic methods for testing ethionamide are imperfectly correlated, and the isolates with MIC of 5 mg/L have the intermediate resistance. A significant proportion of resistant TB cases are susceptible and eligible for ethionamide treatment. Resistance could be explained using only analysis of loci ethA, PfabG1, and inhA for most isolates in the Moscow region. The promoter mutation PfabG1 c(-15)t predicts resistance to ethionamide with high specificity but low sensitivity.
Research on Parallel Optimization Simulation of Fault Prediction Based on SVM

In the fault prediction based on Support Vector Machine(SVM),irrelevant variables in the fault samples spoil the performance of SVM;selecting the weighting factors in weighted SVM directly has many disadvantages;SVM parameters are mostly selected artificially or obtained through experiment time after time,a certain and effective method has not been found. Aiming at the three problems,a method jointly optimizing the feature selection,the weighting factors and the SVM parameters with a modified Artificial Fish Swarm Algorithm(AFSA) was proposed. This method is used in the fault prediction of condensator in naval vessel propulsion plant. The experimental results show that the parallel optimization method can select the best fault features in shorter time and improve the performance of SVM than the separate optimization methods,and MAFSA can get the final result faster than genetic algorithm(GA).
Effect of multi-enzymes supplementation on growth performance, meat quality, ileal digestibility, digestive enzyme activity and caecal microbiota in broilers fed low-metabolizable energy diet

Objective This study was conducted to evaluate the effect of using low energy diet with multi-enzymes supplementation on different biological parameters in broilers. Methods Three hundred Arbor Acres broiler chicks were randomly divided into three groups (Cont, standard metabolizable energy(ME); L-ME, ME reduced by 50 kcal/kg without enzyme; and L-ME-MES, L-ME diet was supplemented with multi-enzymes) with five replicates per group (20 chicks per replicate) at the start of second week. Grower and finisher diets were formulated according to breed specific guide and offered with free access in respective phase (two weeks for grower [8 to 21 d]; two weeks for finisher [22 to 35 d]). External marker method was used to measure the nutrient digestibility. After feeding trial, fifteen birds (one bird per replicate) were selected randomly and slaughtered for samples collection. Results The results exhibited no effect (p>0.05) of dietary treatments on all parameters of growth performance, carcass traits, relative weight of internal organs except bursa and overall parameters of thigh meat quality. Relative weight of bursa was significantly (p<0.05) higher in L-ME than control. Multi-enzymes supplementation in low-ME diet significantly (p<0.05) improved the breast meat pH 24 h, digestibility of crude protein, duodenum weight and length, jejunal morphology, counts of Lactobacillus spp. and Bifidobacterium spp. , lipase and protease activities than control. Jejunum length was increased in both L-ME and L-ME-MES treatments than that of the control (p<0.05). Breast meat cooking loss and color lightness was lower in L-ME (p<0.05) than control. Conclusion It can therefore be concluded that broilers could be reared on low energy diet with supplementation of multi-enzymes without compromising the growth performance. In addition, it is beneficial for other biological parameters of broilers.
lncRNA ROR and miR-125b Predict the Prognosis in Heart Failure Combined Acute Renal Failure

Objective To elucidate the correlation between expression levels of long noncoding RNA (lncRNA) ROR and microRNA-125b (miR-125b) with the prognosis in heart failure (HF) patients combined acute renal failure (ARF). Methods HF patients combined ARF (n = 90) and healthy controls (n = 90) in the same period were included in our hospital from April 2016 to December 2018. Every subject was followed up for 24 months. Serum levels of lncRNA ROR and miR-125b were detected, and their expression correlation was analyzed by Pearson correlation test. Receiver operating characteristic (ROC) curves were depicted for assessing the sensitivity and specificity of lncRNA ROR and miR-125b in diagnosing HF combined ARF. Results lncRNA ROR was upregulated in serum of HF patients combined ARF, and its level was positively correlated to NYHA classification. miR-125b displayed an opposite trend. In serum samples of HF combined ARF, expression level of lncRNA ROR was negatively related to that of miR-125b. Diagnostic potentials of lncRNA ROR and miR-125b in HF combined ARF were confirmed by ROC curve analyses (lncRNA ROR: AUC = 0.9199, cutoff value = 5.595, sensitivity = 92.22%, and specificity = 73.33%; miR-125b: AUC = 0.8509, cutoff value = 2.290, sensitivity = 81.11%, and specificity = 74.44%). After 2-year follow-up, 16 cases were dead. Higher incidences of death and rehospitalization were observed in HF combined ARF cases expressing higher serum level of lncRNA ROR or lower level of miR-125b. Conclusions Serum level of lncRNA ROR is upregulated, and miR-125b is downregulated in HF patients combined ARF. Their levels are linked to NYHA classification, which can be utilized as prognostic biomarkers in HF combined ARF.
Effects of towed-decoys against antiaircraft missile with monopulse seeker

The protection by towed-decoys deployed by an aircraft during an engagement against an anti-air missile equipped with a monopulse seeker is evaluated.The research emphasizes the operational parameters required,including the tether length,the direction of release,under different missile incoming directions.According to the basic principle of noncoherent jamming,the operation process with towed decoy jamming is analyzed and modeled.With the reference standard of miss distance,the jamming performances of towed decoy imposing on monopulse seeker under different decoy parameters are investigated.In the end,the protection envelopes for different engagement scenarios are obtained.The evaluation model is very helpful for selecting proper decoy's parameters in actual battle and engineering.
Metabolites Produced by a New Lactiplantibacillus plantarum Strain BF1-13 Isolated from Deep Seawater of Izu-Akazawa Protect the Intestinal Epithelial Barrier from the Dysfunction Induced by Hydrogen Peroxide

This study aimed to investigate the protective effect of the metabolites produced by a new Lactiplantibacillus plantarum strain BF1-13, isolated from deep seawater (DSW), on the intestinal epithelial barrier against the dysfunction induced by hydrogen peroxide (H2O2) and to elucidate the mechanism underlying the effect. Protective effect of the metabolites by strain BF1-13 on the barrier function of the intestinal epithelial model treated with H2O2 was investigated by the transepithelial electrical resistance (TEER). The metabolites enhanced the Claudin-4 (CLDN-4) expression, including at the transcription level, indicated by immunofluorescence staining and quantitative RT-PCR. The metabolites also showed a suppression of aquaporin3 (AQP3) expression. Lactic acid (LA) produced by this strain of homofermentative lactic acid bacteria (LAB) had a similar enhancement on CLDN-4 expression. The metabolites of L. plantarum strain BF1-13 alleviated the dysfunction of intestinal epithelial barrier owing to its enhancement on the tight junctions (TJs) by LA, along with its suppression on AQP3-facilitating H2O2 intracellular invasion into Caco-2 cells. This is the first report on the enhancement of TJs by LA produced by LAB.
The Synergy of Lampung Provincial Marine and Fishery Services with Muara Tabulih Fisheries in West Coast District in Protection of Turtle Habitat

—Indications of the failure of green turtle protection are shown by the high exploitation of green turtles in various parts of Indonesia, the decrease in the number of turtles landing on nesting beaches, and the low level of community support. The threat of extinction of green turtles is increasingly real if the government does not immediately stop the exploitation of green turtles. To save green turtles from extinction, it is necessary to analyze the protection policies and formulate alternative protection for green turtles in the future. Analysis of the green turtle protection policy is carried out on the conservation activities of the Marine and Fisheries Service. The results of the policy analysis are needed to learn about the effectiveness of protection and management performance of green turtles in the formulation of alternative protection for sea turtles. The Indonesian government through related agencies, such as the Office of Marine Affairs and Fisheries, the Indonesian Institute of Sciences, and the Ministry of Environment have issued several regulations and policies for the protection of endangered species, such as Ratification of the United Nations Convention on Biodiversity through Law No. 5 of 1994, the ratification of the Convention on International Trade in Endangered Species through Presidential Decree No. 43 of 1978; Stipulation of Government Regulation No. 7 of 1999 and Government Regulation No. 8 of 1999. Stipulation of Government Regulation No. 7 of 1999 has protected green turtles along with 236 species of animals and 58 other plant species in the territory of Indonesia.
Recuperación mejorada después de la cirugía: un cambio de paradigma en cuidados peri operatorios. Artículo de revisión

La recuperación mejorada después de la cirugía (ERASÒ) es un protocolo multimodal aplicado a la atención peri operatoria. Estos protocolos están implementados por un equipo multidisciplinario centrado en el paciente, incorporan personal clínico ambulatorio, enfermeras, anestesiólogos, personal de recuperación post operatoria, personal de nutrición, fisioterapeutas, trabajadores sociales y cirujanos. Independientemente de la subespecialidad quirúrgica, todos los protocolos ERASÒ comparten los mismos objetivos: optimización pre operatoria del paciente, disminución del estrés peri operatorio, mantenimiento de la función fisiológica post operatoria y tiempo de recuperación acelerado después de la cirugía. Los protocolos ERASÒ están diseñados para reducir la respuesta al estrés quirúrgico, facilitar el mantenimiento de la composición corporal y función orgánica para lograr una recuperación temprana.