Miracle-dz/UniFAR-FTUs huggingface dataset:
Nutritional characterization of value-added health mix using germinated barley

ABSTRACT The present study was designed to explore the nutraceutical potential of orange peel, malted barley, and fenugreek-based value-added/functional health mix. Purposely, orange peel and fenugreek powder have been combined to germinated barley flour with different ratio . The composite flour was subjected to a nutritional and antioxidant assay. The nutritional analysis revealed that orange peel and malted barley are good sources of protein, fiber, fat, potassium (K), and calcium (Ca). Afterward, the health mix-based functional drink was developed and subjected to physicochemical, functional, and sensory evaluation. The TPC (Total phenolic content), DPPH (1, 1-diphenyl-2-picrylhydrazyl) activity, FRAP (ferric reducing antioxidant power) was found to be increased with the addition of peel flour at various concentrations. The drink (30% peel flour, 60% barley flour and 10% fenugreek flour) is among the other treatments. Sensory scores of formulated value-added drinks decreased with the progression of storage time.
The Influence of the Microbiome on Immunotherapy for Gastroesophageal Cancer

Simple Summary This article delves into the mounting impact of the microbiome on gastroesophageal cancer. Investigating its connection to immunotherapy, this study explores microbial shifts within tumor environments, the gastrointestinal tract, and their consequential effects. Notable associations have surfaced, linking dysbiosis, reduced diversity, treatment resistance, and distinct microbe profiles to improved treatment responses. Comprehending these intricate dynamics holds the key to tailored interventions. The potential of microbiome-based biomarkers is promising for personalized treatment strategies and response prediction. Discussions encompass interventions such as microbiota-based therapeutics and dietary adjustments, which could amplify immunotherapy efficacy by shaping the gut environment. However, realizing the full potential of microbiome-centric approaches hinges on thorough research and substantial clinical trials. This article highlights the evolving role of the microbiome and its dual impact on both gastroesophageal cancer and the efficacy of immunotherapy in reshaping future treatment paradigms. Abstract Immunotherapy has shown promise as a treatment option for gastroesophageal cancer, but its effectiveness is limited in many patients due to the immunosuppressive tumor microenvironment (TME) commonly found in gastrointestinal tumors. This paper explores the impact of the microbiome on the TME and immunotherapy outcomes in gastroesophageal cancer. The microbiome, comprising microorganisms within the gastrointestinal tract, as well as within malignant tissue, plays a crucial role in modulating immune responses and tumor development. Dysbiosis and reduced microbial diversity are associated with poor response rates and treatment resistance, while specific microbial profiles correlate with improved outcomes. Understanding the complex interactions between the microbiome, tumor biology, and immunotherapy is crucial for developing targeted interventions. Microbiome-based biomarkers may enable personalized treatment approaches and prediction of patient response. Interventions targeting the microbiome, such as microbiota-based therapeutics and dietary modifications, offer the potential for reshaping the gut microbiota and creating a favorable TME that enhances immunotherapy efficacy. Further research is needed to reveal the underlying mechanisms, and large-scale clinical trials will be required to validate the efficacy of microbiome-targeted interventions.
The Application of British and American Literature in College English General Education

: General education is an important direction in the current university education process. It requires non-professional general education for all students, so that students can develop comprehensively and healthily. The promotion of general education concept has an important guiding role in the setting of college English curriculum. It is required to cultivate students' cross-cultural language ability in the teaching process, to meet the needs of talent cultivation under the current new situation, and to realize the teaching of English curriculum and the purpose of training talents. The integration of English and American literary works into the English general education of the university is a new way advocated by the current college English education community. Through this teaching method, college students can carry out effective English texts under the guidance of college English teachers. Students have a strong interest in English reading, so that they can use the English and American literature to conduct active English learning behavior both inside and outside the classroom. In this paper, a control period and an experimental group were set up, and one semester was used during the experimental period. The experimental group used the education method of integrating English and American literature education into the college English general education. The control group was taught in the traditional teaching mode. Through the data analysis and comparison, it is found that after the teaching method of integrating English and American literature education into college English general education, the performance of the experimental group has been significantly improved, and the excellent rate has increased by 10%, and the good rate has improved. 30%, the pass rate has increased by 7%, and the progress is very obvious. In addition, after the teaching experiment, there are 13 people who are very interested in the education model of English and American literature education in college English general education, 15 people are interested. Only 2 people are not interested, 93.3% are interested, and 6.7% are uninterested. Most of the students are interested. Most students hope that the school will continue to use this teaching mode.
A Parallel Ocean Model With Adaptive Mesh Refinement Capability For Global Ocean Prediction

An ocean model with adaptive mesh refinement (AMR) capability is presented for simulating ocean circulation on decade time scales. The model closely resembles the LLNL ocean general circulation model with some components incorporated from other well known ocean models when appropriate. Spatial components are discretized using finite differences on a staggered grid where tracer and pressure variables are defined at cell centers and velocities at cell vertices (B-grid). Horizontal motion is modeled explicitly with leapfrog and Euler forward-backward time integration, and vertical motion is modeled semi-implicitly. New AMR strategies are presented for horizontal refinement on a B-grid, leapfrog time integration, and time integration of coupled systems with unequal time steps. These AMR capabilities are added to the LLNL software package SAMRAI (Structured Adaptive Mesh Refinement Application Infrastructure) and validated with standard benchmark tests. The ocean model is built on top of the amended SAMRAI library. The resulting model has the capability to dynamically increase resolution in localized areas of the domain. Limited basin tests are conducted using various refinement criteria and produce convergence trends in the model solution as refinement is increased. Carbon sequestration simulations are performed on decade time scales in domains the size of the North Atlantic andmore » the global ocean. A suggestion is given for refinement criteria in such simulations. AMR predicts maximum pH changes and increases in CO{sub 2} concentration near the injection sites that are virtually unattainable with a uniform high resolution due to extremely long run times. Fine scale details near the injection sites are achieved by AMR with shorter run times than the finest uniform resolution tested despite the need for enhanced parallel performance. The North Atlantic simulations show a reduction in passive tracer errors when AMR is applied instead of a uniform coarse resolution. No dramatic or persistent signs of error growth in the passive tracer outgassing or the ocean circulation are observed to result from AMR. « less
A Simple Model of the Rise and Fall of Civilizations

The literature on the fall of civilizations spans from the archaeology of early state societies to the history of the 20th century. Explanations for the fall of civilizations abound, from general extrinsic causes (drought, warfare) to general intrinsic causes (intergroup competition, socioeconomic inequality, collapse of trade networks) and combinations of these, to case-specific explanations for the specific demise of early state societies. Here, we focus on ancient civilizations, which archaeologists typically define by a set of characteristics including hierarchical organization, standardization of specialized knowledge, occupation and technologies, and hierarchical exchange networks and settlements. We take a general approach, with a model suggesting that state societies arise and dissolve through the same processes of innovation. Drawing on the field of cumulative cultural evolution, we demonstrate a model that replicates the essence of a civilization’s rise and fall, in which agents at various scales—individuals, households, specialist communities, polities—copy each other in an unbiased manner but with varying degrees of institutional memory, invention rate, and propensity to copy locally versus globally. The results, which produce an increasingly extreme hierarchy of success among agents, suggest that civilizations become increasingly vulnerable to even small increases in propensity to copy locally.
An assessment of O3-related health risks and economic losses in typical regions of China

Introduction As one of the key areas for air pollution prevention and control in China, the Fenwei Plain is experiencing serious near-surface O3 pollution, which is a key issue that needs to be solved urgently. Methods Based on pollutant concentration monitoring data and meteorological and health data over the same period, this study analyzed the temporal and spatial characteristics, the relationships with meteorological factors of O3 pollution, and the health effects and economic losses caused by exposure to O3 pollution using environmental health risk and environmental value assessment methods in 11 cities on the Fenwei Plain in China from 2014 to 2020. Results The results showed that O3 pollution has become increasingly serious on the Fenwei Plain in recent years. The annual average concentration of O3_8h_max showed an overall upwards trend, with an increase of 32.39% in 2020 compared to 2014. The mean concentrations observed in summer were the highest, followed by spring and autumn, and the lowest was in winter. The O3 concentration had a significant positive correlation with air temperature and sunshine hours. The evaluation results of the impact of air pollution on population health showed that the number of premature deaths caused by O3 pollution fluctuated and increased during 2014–2020. In 2020, the numbers of total, cardiovascular and respiratory deaths attributable to O3 pollution on the Fenwei Plain were 6,867 (95% CI: 3,739–9,965), 3,652 (95% CI: 1,363–5,905), and 1,257 (95% CI: 747–2,365), respectively, and the total number of premature deaths related to O3 exposure increased by 48.05% compared with 2014. The health and economic losses attributed to O3 pollution on the Fenwei Plain during the study period were 44.22 (95% CI: 22.17–69.18), 47.16 (95% CI: 23.64–73.77), 68.28 (95% CI: 34.27–106.31), 114.44 (95% CI: 57.42–177.76), 110.85 (95% CI: 55.45–172.52), 116.41 (95% CI: 58.24–180.74), and 116.81 (95% CI: 58.00–180.88) billion yuan, respectively. In Linfen City, the increasing rate of the number of premature deaths reached 283.39% because the O3 concentration increased greatly. Discussion Due to high O3 concentrations and obvious population growth in Xi’an, the problems of premature death and health and economic losses attributed to O3 concentrations exceeding the standard value are prominent.
Preliminary Validation of the Revised Illness Perception Questionnaire for Patients with Nasopharyngeal Carcinoma in China

Nasopharyngeal carcinoma is a common and highly malignant cancer in southern China. It is important to accurately assess the illness perception of nasopharyngeal carcinoma according to the common-sense model of self-regulation. The purpose was to validate the Chinese version of the Revised Illness Perception Questionnaire for patients with Nasopharyngeal carcinoma. A cross-sectional survey of 631 patients with Nasopharyngeal carcinoma was conducted in Guangzhou, China. The reliability of the scale was evaluated using Cronbach’s alpha. The factor structure was assessed using exploratory factor analysis (EFA) of each dimension. The EFA revealed that the 29-item self-rated scale has a seven-factor structure consistent with the original scale and explained 67.3% of the variance after extraction and rotation. The scale showed satisfactory reliability. The item–total correlations ranged from −0.16 to 0.64 (p < 0.05). The item–subscale correlations ranged from 0.46 to 0.91 (p < 0.05). The item–other subscale correlations ranged from −0.38 to 0.51 and from −0.21 to 0.56 (p < 0.05). Significant correlations were found between the timeline (acute/chronic) (r = 0.224, r = 0.166), consequences (r = 0.415, r = 0.338), timeline cyclical (r = 0.366, r = 0.284), emotional representations (r = 0.497, r = 0.465), personal control (r = −0.122, r = −0.134), treatment control (r = −0.135, r = −0.148), and illness coherence (r = −0.261, r = −0.213) subscales, and depression, anxiety (p < 0.05). The scale revealed acceptable reliability, factorial validity, and construct validity. It could be used to assess the illness representations of Chinese patients with nasopharyngeal carcinoma.
Targeting Key Players of Neuroendocrine Differentiation in Prostate Cancer

Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of prostate cancer (PC) that commonly emerges through a transdifferentiation process from prostate adenocarcinoma and evades conventional therapies. Extensive molecular research has revealed factors that drive lineage plasticity, uncovering novel therapeutic targets to be explored. A diverse array of targeting agents is currently under evaluation in pre-clinical and clinical studies with promising results in suppressing or reversing the neuroendocrine phenotype and inhibiting tumor growth and metastasis. This new knowledge has the potential to contribute to the development of novel therapeutic approaches that may enhance the clinical management and prognosis of this lethal disease. In the present review, we discuss molecular players involved in the neuroendocrine phenotype, and we explore therapeutic strategies that are currently under investigation for NEPC.
Activation of G-Protein-Coupled Estrogen Receptor 1 (GPER1) Reduces Progression of Vulvar Carcinoma Cells

Whether G protein-coupled estrogen receptor 1 (GPER1) is tumor-promoting or tumor-suppressive depends in part on tumor entity. Little is known about the function of GPER1 in vulvar carcinoma. In this work, we aim to clarify what role GPER1 plays in vulvar cancer, tumor-promoting or tumor-suppressive. Localization of GPER1 in A431 and CAL-39 vulvar carcinoma cells was examined by immunofluorescence. Using a tissue microarray of vulvar neoplasias, the correlation between GPER1 expression and grade of malignancy was investigated. A431 and CAL-39 cells were treated either with GPER1 agonist G1 or antagonist G36. Proliferation was quantified by BrdU assay and viability examined using Resazurin assay. Morphological changes were analyzed by microscopy and measured using ImageJ. Cell migration was analyzed by gap closure assay. Clonogenic potential was tested by colony and sphere formation. Expression of estrogen receptors was examined by Western blot. GPER1 was found consistently expressed in vulvar neoplasia tissues. The immune-reactive score was found to be significantly higher in tissue samples of lymph node metastases and neoplasias with grade 3. In A431 and CAL-39 vulvar carcinoma cells, GPER1 expression was mainly found in the cytoplasm and nuclei. Treatment of A431 and CAL-39 cells with GPER1 agonist G1 resulted in a decrease in proliferation and migration. In addition, colony formation and tumor sphere formation were reduced. Furthermore, morphological signs of necrosis and reduction in cell viability after G1 treatment were observed. The GPER1 antagonist G36 did not have significant effects on vulvar carcinoma cells. Neither agonist G1 nor antagonist G36 treatment resulted in altered expression of estrogen receptors. Activation of GPER1 with GPER1 agonist G1 reduces the tumorigenic potential of the vulvar carcinoma cells. It can be deduced from this that GPER1 appears to have a tumor-suppressive effect in vulvar carcinoma.
A Geographic Information System approach to modeling nutrient and sediment transport

The objective of this study was to develop a water quality model to quantify nonpoint-source (NPS) pollution that uses a geographic information system (GIS) to link statistical modeling of nutrient and sediment delivery with the spatial arrangement of the parameters that drive the model. The model predicts annual nutrient and sediment loading and was developed, calibrated, and tested on 12 watersheds within the Lake Ray Roberts drainage basin in north Texas. Three physiographic regions are represented by these watersheds, and model success, as measured by the accuracy of load estimates, was compared within and across these regions.
Analysis of Spatial Unbalance and Convergence of Agricultural Total Factor Productivity Growth in China—Based on Provincial Spatial Panel Data from 1978 to 2020

Using the provincial panel data from 1978 to 2020 as the research object, this study employs the fixed effect SFA-Malmquist model to measure the agricultural total factor productivity of each province and city, and the spatial correlation of China’s agricultural total factor productivity is determined by Moran’s I. On this basis, three weights (adjacency, economy, geography) are included as spatial factors in three spatial β-convergence models (SAR, SEM and SDM), and the spatial convergence characteristics of China’s agricultural total factor productivity are analyzed in different time periods and different regions. The study found that: First, China’s agricultural total factor productivity shows a growing trend, but as time goes on, its growth rate gradually slows down, and the growth rate in the eastern region is higher than that in the central and western regions. Second, China’s agricultural total factor productivity has significant spatial correlation and spatial convergence characteristics. The differences in agricultural total factor productivity in various regions are shrinking over time, and the spatial spillover effect significantly shortens the convergence process. Due to spatial convergence, while carrying out agricultural production, all regions should thoroughly consider the advantages of agricultural resources in neighboring regions and strengthen cooperation and exchanges between regions.
Quality Assessment of the Armourstones for Some Black Sea Rubble Mound Breakwaters, Turkey

ABSTRACT O ZDEN , U.A. and T OPAL , T. , 2007. Quality assessment of the armourstones for some Black Sea rubble mound breakwaters, Turkey. Journal of Coastal Research, SI 50 (Proceedings of the 9th International Coastal Symposium), 190 – 194. Gold Coast, Australia, ISSN 0749.0208 The Black Sea coastline is a hazardous region in Turkey, especially in winter, due to the dominant wave action. Therefore, rubble mound breakwaters used as ship shelters are vital structures, especially for the fishermen. Construction of the breakwater requires good quality, durable armourstones. Due to the nature of the rubble mound breakwaters, armourstones of various sizes and types are used in the construction of these structures. The deterioration of these armourstones with time may result in the failure of the breakwater. In this study, the quality and durability of the armourstones (mainly limestone, andesite and sandstone) used or to be used in three rubble mound breakwaters are investigated through field and laboratory studies. Among the studied armourstones, the three limestones are found to be good in long-term quality and durability. However, the sandstone displays poor performance, whereas the andesite is marginal. Both static durability index and CIRIA/CUR evaluation successfully predict the long-term durability of the armourstones.
Historic Littoral Cones in Hawaii

Littoral cones are formed by steam explosions resulting when lava flows enter the sea. Of about 50 littOral cones on the shores of Mauna Loa and Kilauea on the island of Hawaii, three were formed in historic time: 1840, 1868, and 1919. Five new chemical analyses of the glassy ash of the cones and of the feeding lava show that there is no chemical interchange between molten lava and sea water during the brief period they are in contact. The littoral cone ash contains a lower Fe20g / (Fe20g + FeO) ratio than does its feeding lava because drastic chilling reduces the amount of oxidation. A large volume of lava entering the sea (probably more than 50 million cubic yards) is required to produce a littoral cone. All the histOric littOral cones were fed by aa flows. The turbulent character of these flows and the included cooler, solid material allows ingress of sea water to the interior of the flow where it vaporizes and explodes. The cooler, more brittle lava of the aa flows tend to fragment and shatter more readily upon contact with water than does lava of pahoehoe flows. LITfORAL CONES are common features on the shores of the younger volcanoes of Hawaii (Wentworth and Macdonald, 1953:28). These cinder cones do not mark the site of a primary volcanic vent but rather are produced by the violent steam explosions which result when some lava flows enter the sea. Upon such occasions the contact of molten lava with sea water produces great jets of steam hundreds of feet high. These blasts carry the chilled and shattered lava high into the air. If wind and tOpography permit, some of this material falls back on the land and builds up a cone. Most of the material falls into the sea and is removed by ocean currents. Because of their location on the sea coast, littOral cones are very transient features and are rapidly removed by the sea; consequently they are found only on the youngest active volcanoes. On the shores of Kilauea and Mauna Loa on the island of Hawaii there are approximately 50 littoral cones. No cones are known on the other 1 U.S. Geological Survey, Hawaiian Volcano Observawry, Hawaii, and Isotopes, Inc., Westwood, New Jersey. Manuscript received September 11, 1963. Publication authorized by the Director, U.S. Geological Survey. 3 three volcanoes (Mauna Kea, Kohala, and Hualalai) of which the island is composed, nor have any littOral cones been mapped on any of the other Hawaiian Islands. In historic time, cones have been formed at only three localities (Fig. 1). These three cones are of particular interest because their age and conditions of formation are known and because the lava flows which fed them can be identified. The three historic littoral cone localities are: ( 1) Sand Hills, produced by the 1840 Kilauea flow; (2) Puu Hou, produced by the 1868 Mauna Loa flow; and (3) the cone produced by the 1919 Mauna Loa flow.