Miracle-dz/UniFAR-FTUs huggingface dataset:
Focus shift control of a novel 30 kW laser remote scanner for large-scale industrial sheet and plate metal applications

In today’s business environment, the trend towards more product variety and customization is unbroken. Due to this development, the need of agile and reconfigurable production systems emerged to cope with various products and product families. To design and optimize production systems as well as to choose the optimal product matches, product analysis methods are needed. Indeed, most of the known methods aim to analyze a product or one product family on the physical level. Different product families, however, may differ largely in terms of the number and nature of components. This fact impedes an efficient comparison and choice of appropriate product family combinations for the production system. A new methodology is proposed to analyze existing products in view of their functional and physical architecture. The aim is to cluster these products in new assembly oriented product families for the optimization of existing assembly lines and the creation of future reconfigurable assembly systems. Based on Datum Flow Chain, the physical structure of the products is analyzed. Functional subassemblies are identified, and a functional analysis is performed. Moreover, a hybrid functional and physical architecture graph (HyFPAG) is the output which depicts the similarity between product families by providing design support to both, production system planners and product designers. An illustrative example of a nail-clipper is used to explain the proposed methodology. An industrial case study on two product families of steering columns of thyssenkrupp Presta France is then carried out to give a first industrial evaluation of the proposed approach. © 2017 The Authors. Published by Elsevier B.V. Peer-review under responsibility of the scientific committee of the 28th CIRP Design Conference 2018.
GPAlVal-50 Mutation in the Mating-Factor Signaling Pathway in Saccharomyces cerevisiae

The GPAI gene of Saccharomyces cerevisiae encodes a protein that is highly homologous to the a subunit of mammalian hetrotrimeric G proteins and is essential for haploid cell growth. A mutation of the GPA1 protein, GPA1Val-50, in which Gly-50 was replaced by valine, could complement the growth defect of a GPAI disruption, gpal::HIS3. However, cells with gpal ::HIS3 expressing the GPAlVaI-S5 protein were supersensitive to a-factor in a short-term incubation but resumed growth after long-term incubation even after exposure to high concentrations of a-factor. The former phenotype associated with GPAJVal-S0 is recessive, and the latter phenotype is dominant to GPAI'. The supersensitivity of GPAVal-S0 to a-factor was dependent on STE2 and STE4, which demonstrates that this GPA1va5s0-produced phenotype requires the mating-factor receptor and the 13 subunit of the G protein. The double mutant of sst2-1 GPAIVa-50 recovered from division arrest, which suggested that SST2 is not required for recovery of the GPAJVal-50 mutant.
Gene Regulation and Oncogenes

Oncogenic transformation of cells is accompanied by many biological changes. Tumor cells are often less differentiated than their normal counterparts. They either ignore the extra cellular signals which suppress division of normal cells or respond to inappropriate signals with cell division. Tumor cells have a genetic plasticity that normal cells do not which toler ates, and may even promote, aneuploidy, chromosome re arrangements, and gene amplifications. Finally, tumor cells may lose their sense of position in the body and migrate to inappropriate sites to form mÃ©tastases.Each of these biological processes is a manifestation of a change in the pattern of gene regulation by cells. Subgroups of genes undergo changes in expression during differentiation, hormonal signaling, progres sion through the cell cycle, and probably also in the transition to cellular states characterized by genetic plasticity. Perhaps only at this fundamental level, gene regulation (primarily reg ulation of transcription), can the interrelationship of changes affecting oncogenic transformation be investigated. Most of the known oncogenes have activities which signal changes in gene expression. Many oncogenes are thought to affect transformation by generating aberrant levels of activity in signal transduction pathways the normal function of which in many cases is to regulate growth by signaling changes in gene expression. For example, oncogenes can specify growth factors (e.g., v-sis/PDGF), hormone receptors (e.g., v-erbB/ EGF-R), and intracellular signal transduction proteins (e.g., vras, \-src). Some nuclear oncogenes are transcription factors (see below) and others may regulate the activity of transcription factors. Thus, in a simplistic sense, oncogenes and transcription are interrelated in that oncogene products have as their primary effect changes in transcription of cellular genes, and by this they affect oncogenic transformation of cells.
Running head: CREDIBILITY OR CREDULITY? Credibility or Credulity? Examining Political Organization-Public Relationships in an Election of Interloping Candidates by

This national online survey (N = 493) examined the political organization-public relationship (POPR) that voters perceived with their own political party and their opposing political party, as well as voters’ assessment of the credibility of candidates running for president during the primary season of the 2016 election. Results indicated that while credibility assessment of one’s own party’s candidate was much as expected, POPR with the Democratic Party was generally stronger than that with Republican Party across the board. Data showed no support that a poor POPR with one's own party would drive voters to support interloper candidates. Researchers conclude by reflecting on the importance of POPR with the opposing party and what weak relationships may mean for parties in the long term.
Historical Distribution of Metasequoia Referenced to Paleoclimate Factors

Metasequoia Miki 1941 was a prominent element of vegetation distributed in the high latitudes of Northern Hemisphere from the late Early Cretaceous to Miocene. However, at present this genus survived only in some mountain areas of Hubei, Hunan and Chongqing of China as a relict genus. Although the distribution of Metasequoia through geologic time have been studied in detail, the relationship between its distribution and paleoclimates remained unclear. In this paper, the potential migratory routes of Metasequoia are explained on the basis of the its fossil records plotted in the paleoclimate maps. It can be concluded that: 1) the Warm Temperate climate favored to the diffusion of Metasequoia, while the Arid climate curbs its migration; 2) with the global temperature decreased markedly since Pliocene, Metasequoia was forced to migrate to the south, and survived only in South China, under the Warm Temperate climate support. K e y w o r d s : Metasequoia, distribution, paleoclimate factors
STUDY OF DISEASE-SPECIFIC QUALITY OF LIFE OUTCOME AFTER SURGICAL INTERVENTION IN PATIENTS WITH CHRONIC SUPPURATIVE OTITIS MEDIA- TERTIARY HOSPITAL BASED STUDY

BACKGROUND: Chronic Suppurative Otitis Media (CSOM) affects approximately 2% of the population, in South East Asia CSOM has a prevalence of approximately 5.2% in the general population. Ear disease can also cause debilitating physical symptoms such as ear pain and discharge which negatively impacts quality of life (QoL). Therefore, it is important to have effective measures of quality of life (QoL) and health status to evaluate the burden of disease and effectiveness of treatments. Health-related quality of life (HR-QOL) has an ever increasing importance as an outcome parameter. For the proof of the success of surgical interventions, the evidence of an improvement of HR-QOL in addition to an improvement in objectively measurable parameters is required,so this prospective study was conducted in our department with the objective,To compare disease-specific quality of life in patients with CSOM before and after ear surgery using COMOT -15 questionnaire. METHOD: This prospective study was conducted in 213 patients in the Department of Otorhinolaryngology Head and Neck Surgery, Government Medical College and associated SMHS Hospital Srinagar. All those patients who were treated at the Department of Otorhinolaryngology, Head and Neck Surgery at SMHS hospital Srinagar and fulfilling the inclusion criteria were included in the study. Data was collected at three times of measurement (TM): pre-operatively (TM1), 6 months after surgery (TM2), and 12 months after surgery (TM3) using COMOT-15 questionnaire.Tympanoplasty,Canal wall-up,canal wall-down mastoidectomy ,and ossicular reconstruction was done. RESULTS: Our study group comprised of total 213 patients with majority of patients 157 (73.70%) patients were in the age group 18 to 30 years of age.Of 213 patients 129 (60.56%) were females and 84 (39.43) were males . The results of present study using COMOT-15 for Disease specific HR-QOL suggested that patients benefitted from surgery. Total mean Comot-15 values were (43.69, 21.10, 18.99 preoperatively, at 6 months and at 1 year respectively) Conclusion : By observations of our study we concluded that Disease specific health related quality of life measured with COMOT-15 improved after surgical intervention at 6 months and 1year.
The RNase Rny 1 p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae

Stress conditions stimulate a variety of responses in eukaryotic cells, ranging from stress neutralization to cell death. Recent studies have described a novel aspect of stress responses in eukaryotic cells wherein cytosolic tRNAs are separated into half molecules by cleavage in the anticodon loop. Such tRNA cleavage has been observed during amino acid starvation in Tetrahymena thermophila and Aspergillus fumigatus (Lee and Collins, 2005; Jochl et al., 2008), during development in the bacterium Streptomyces coelicolor (Haiser et al., 2008), and in human, plant, and yeast systems during oxidative stress (Thompson et al., 2008; see Yamasaki et al. on p. 35 of this issue). More­ over, large­scale small RNA sequencing studies have identified cleaved tRNAs in human cells (Kawaji et al., 2008). Interest­ ingly, tRNA fragments are also observed in the urine and sera of cancer patients, with levels correlated with the tumor burden (Waalkes et al., 1975; Borek et al., 1977; Speer et al., 1979; Tamura et al., 1987). An unresolved issue is the mechanism and significance of stress­induced tRNA cleavage. We demonstrate that cytosolic RNAs in yeast are cleaved during oxidative stress by release of the endonuclease RNase in Yeast 1 (Rny1p) from the vacuole into the cytosol. Rny1p also modulates cell survival during oxidative stress, but this effect is independent of its catalytic ability. These observations argue that release of Rny1p from the vacuole both promotes tRNA cleavage and separately activates a downstream pathway that promotes cell death. This is analogous to the classical example of cytochrome c release from mitochondria promoting apoptosis, and may be a general principle of how cells sense damage to membrane­ bound compartments. Strikingly, the human orthologue of Rny1p, RNASET2, is a tumor suppressor that functions in a manner inde­ pendent of its catalytic activity (Acquati et al., 2005; Smirnoff et al., 2006), which suggests that a similar control circuit occurs in mammalian cells and impacts on tumor progression.
Cranwell, J.C. and Whitamore, Kathy and Britton, John and Leonardi-Bee, Jo (2016) Alcohol and tobacco content in UK video games and their association with alcohol and tobacco use among young people

To determine the extent to which video games include alcohol and tobacco content and assess the association between playing them and alcohol and smoking behaviors in adolescent players in Great Britain. Assessment of substance in the 32 UK bestselling video games of 2012/2013; online survey of adolescent playing of 17 games with substance content; and content analysis of the five most popular games. A total of 1,094 adolescents aged 11–17 years were included as participants. Reported presence of substance content in the 32 games; estimated numbers of adolescents who had played games; self-reported substance use; semiquantitative measures of substance content by interval coding of video game cut scenes. Nonofficial sources reported substance content in 17 (44 percent) games but none was reported by the official Pan European Game Information (PEGI) system. Adolescents who had played at least one game were significantly more likely ever to have tried smoking (adjusted odds ratio [OR] 2.70, 95 percent confidence interval [CI] 1.75–4.17) or consumed alcohol (adjusted OR 2.35, 95 percent CI 1.70–3.23). In the five most popular game episodes of alcohol actual use, implied use and paraphernalia occurred in 31 (14 percent), 81 (37 percent), and 41 (19 percent) intervals, respectively. Tobacco actual use, implied use, and paraphernalia occurred in 32 (15 percent), 27 (12 percent), and 53 (24 percent) intervals, respectively. Alcohol and tobacco content is common in the most popular video games but not reported by the official PEGI system. Content analysis identified substantial substance content in a sample of those games. Adolescents who play these video games are more likely to have experimented with tobacco and alcohol.
Survey on Cyber Security of Industrial Control Systems

: Today all critical infrastructure and industrial systems apply network-based automation and control systems to monitor and control their processes. Safe, effective and efficient management, coordination and operation of these units are possible through these control systems. In other words, automation and control systems are considered as the brain and nervous systems of critical infrastructure and industrial systems. Using computer and information technology to enhance the quality, performance and reliability of control systems, caused them facing unexpected threats; Cyber attacks are the most important ones. Following the Stuxnet attack, Industrial Cyber Security (ICS) has become a serious challenge for control engineering studies. Over the last few years, many researches have been conducted in the field of ICS. In this paper, we survey the literature of this area from the perspective of control engineering to present an overview of this issue and informing experts of this field with the related importance and research opportunities.
SOI PHOTONIC CRYSTAL WAVEGUIDES OPERATING IN TELECOMMUNICATION RANGE FOR INTEGRATED CIRCUITS

In this report, we present the design and the numerical investigation of the mode property of SOI photonic crystal waveguide (SOI PCWs) operating in telecommunication range, i.e., O-band (1260 – 1360 nm) with TE polarization. The SOI PCWs including conventional W1 and slot SOI PCWs have been designed to exploit two kinds of mode: W1-like and true-slot. For that purpose, the geometric parameters of the SOI PCW with the triangular PhC structure are chosen as follows. The thickness of the silicon slab is fixed at 300 nm, the size of the hole is about 210 nm and the lattice constant is selected of 340 nm. The width of the waveguide is modified from W1 to W1.50 and the width of the slot was selected from 100 nm to 150 nm to engineer the W1-like and true slot modes. The covering material with a refractive index of 1.445 corresponding to some active materials is considered. The demonstrated SOI PCWs in this work might find applications in optical integrated circuits, monitoring or sensing purposes.
Evaluate the Application Levels of PPM Framework in Product Design and Innovation

Today’s highly belligerent production environment, it is a colossal and a continuous challenge to manufacturing industries in selecting the best-fit product with right balance of new product innovation that increases the industry value and minimize the manufacturing budget. The main purpose of this exploratory study is to evaluate and establish the application levels of PPM process frameworks which are used to select the best-fit product portfolios and project selection methods which are used for the selection of right products in the perspective of project portfolio management (PPM). This paper presents the study findings which were established based on the statistical data analysis using cumulative weighed average technique that was performed on the primary data. The primary data was collected through a pre-tested and well-structured self-administered questionnaire. The results reveal that the application intensity of process frameworks and selection methods in product design and innovations are moderate. PMI-Project Portfolio Management Process is a most widely used process framework followed by inhouse process frameworks and Return on Investment and Net Present Value are most widely used methods in manufacturing firms followed by Balanced Scorecard, Weighted Scoring Model, Payback Method and Check-List Model.
A N D PLASMA MEMBRANE LOCALIZATION METABOLISM OF ALKALINE PHOSPHODIESTERASE I IN MOUSE PERITONEAL MACROPHAGES*

We have previously reported on the metabolism of the macrophage plasma membrane enzyme 5'-nucleotidase (1, 2). However, although this enzyme is easily detected in resident peritoneal macrophages, it is absent in thioglycollatestimulated cells. In an effort to learn more about the physiology of the plasma membrane of inflammatory cells we therefore chose to examine the enzyme alkaline phosphodiesterase I (EC 3.1.4.1). This enzyme has been previously reported to be a component of the plasma membrane of rat and mouse liver cells (3, 4, 5) and rabbit alveolar macrophages (6). In this work we present evidence that it is also associated with the plasma membrane of mouse peritoneal macrophages. We also report on the rates of synthesis and degradation of the enzyme in resident and inflammatory populations.
Insulin Detemir ReducesWeight Gain As a Result of Reduced Food Intake in PatientsWith Type 1 Diabetes

RESEARCHDESIGNANDMETHODS—A 32-week, randomized crossover design trial was undertaken in 23 patients with type 1 diabetes. Patients on a basal-bolus regimen (with insulin aspart as the bolus insulin) were randomly assigned to insulin detemir or NPH insulin as a basal insulin for 16 weeks, followed by the other basal insulin for 16 weeks. At the end of each 16-week period, total energy expenditure, resting energy expenditure, diet-induced thermogenesis, activity energy expenditure, energy intake, weight change, glycemic control, hypoglycemic episodes, and hormones that affect satiety and fuel partitioning were measured.
Experimental Study of Real-Time Classification of 17 Voluntary Movements for Multi-Degree Myoelectric Prosthetic Hand

The myoelectric prosthetic hand is a powerful tool developed to help people with upper limb loss restore the functions of a biological hand. Recognizing multiple hand motions from only a few electromyography (EMG) sensors is one of the requirements for the development of prosthetic hands with high level of usability. This task is highly challenging because both classification rate and misclassification rate worsen with additional hand motions. This paper presents a signal processing technique that uses spectral features and an artificial neural network to classify 17 voluntary movements from EMG signals. The main highlight will be on the use of a small set of low-cost EMG sensor for classification of a reasonably large number of hand movements. The aim of this work is to extend the capabilities to recognize and produce multiple movements beyond what is currently feasible. This work will also show and discuss about how tailoring the number of hand motions for a specific task can help develop a more reliable prosthetic hand system. Online classification experiments have been conducted on seven male and five female participants to evaluate the validity of the proposed method. The proposed algorithm achieves an overall correct classification rate of up to 83%, thus, demonstrating the potential to classify 17 movements from 6 EMG sensors. Furthermore, classifying 9 motions using this method could achieve an accuracy of up to 92%. These results show that if the prosthetic hand is intended for a specific task, limiting the number of motions can significantly increase the performance and usability.
Energy-efficient clustering for Wireless Sensor Networks-A Survey

Research in clustering has been very active in the last two decades. Clustering schemes decreases the communication overheads, intern reducing the power consumptions and interferences among nodes. Clustering is one of the best known methods used to face this type of challenges. In this paper, we study and compare various objectives, features & characteristics of some of the popularly explored clustering algorithms & published clustering schemes in Wireless Sensor Networks like advantages and disadvantages of respective clustering schemes. This paper also presents future research topics and highlights the challenges in clustering in Wireless sensor networks.
Employing the CEP Paradigm for Network Analysis and Surveillance

—In this paper, we present a network analysis and surveillance system based on the Complex Event Processing (CEP) paradigm. We demonstrate how complex event hierarchies based on single packets can be leveraged for detecting attacks such as, e.g., SYN Flooding, and present experimental performance results indicating that current CEP implementations running on consumer class computers are well capable of analyzing network traffic volumes with such patterns in the Gigabit range, rendering our approach applicable for enterprise network monitoring.
Laparoscopic Versus Open Appendicectomy: A Clinical Observation

Background: Acute appendicitis is a common indication for abdominal surgery with a life time incidence between 7-9% and appendicectomy is one of the most common surgical procedures. Open appendicectomy (OA) performed through the right lower quadrant incision was first described in 1894. It has become the standard treatment of choice for acute appendicitis, remaining mainly unchanged for 100 years due to its favorable efficacy and safety. Laparoscopic appendicectomy (LA), first performed by Semm in 1983, has gradually gained acceptance. However, there remains a continuining controversy in the literature regarding the most appropriate method of removing the inflamed appendix. Methods: In a hospital based single center observation on laparoscopic versus open appendicectomy, 224 out of 355 consecutive patients consented to participate. 132 patients were allocated for open procedure and remaining 92 patients under went laparoscopic procedure.18 patients out of 92 needed to be converted to open appendicectomy.131 patients did not participated. Length of stay in hospital was the primary consideration, while operating time, postoperative morbidity, duration of convalescence and cosmesis were secondary consideration. Results: Intention-to-treat analysis revealed an equally short hospital stay in the two groups (average median 2 days though most patients could discharge after 1 day in laparoscopic group). The median time to return to normal activity (7 versus 10 days) and work (10 versus 16 days) was significantly shorter following laparoscopy. Laparoscopy was associated with fewer wound infections and improved cosmesis but the operating time was longer (60 versus 40min). Laparoscopy was associated with more intraperitoneal abscesses (5 versus 1 per cent) but, adjusted for a greater number of gangrenous or perforated appendices in this group, the difference failed to reach statistical significance. Conclusion: Though hospital stay was equally short in open and laparoscopic most patients could go home on 2 nd post-operative day after laparoscopic appendicectomy. Laparoscopic appendicectomy was associated with fewer wound infections, faster recovery, earlier return to work, less post operative pain and improved cosmesis though slight and negligible higher intra-abdominal abscess.