Miracle-dz/UniFAR-FTUs huggingface dataset:
Bisphenol S Reduces Pig Spermatozoa Motility through Different Intracellular Pathways and Mechanisms than Its Analog Bisphenol A

Bisphenol A (BPA: 2,3-bis (4-hydroxyphenyl) propane) is an environmental chemical widely used in the manufacturing of epoxy polymers and many thermoplastic consumer products. Serious concerns about its safety led to the development of analogs, such as BPS (4-hydroxyphenyl sulfone). Very limited studies about BPS’s impact on reproduction, specifically in spermatozoa, exist in comparison with BPA. Therefore, this work aims to study the in vitro impact of BPS in pig spermatozoa in comparison with BPA, focusing on sperm motility, intracellular signaling pathways and functional sperm parameters. We have used porcine spermatozoa as an optimal and validated in vitro cell model to investigate sperm toxicity. Pig spermatozoa were exposed to 1 and 100 μM BPS or BPA for 3 and 20 h. Both bisphenol S and A (100 μM) significantly reduce pig sperm motility in a time-dependent manner, although BPS exerts a lower and slower effect than BPA. Moreover, BPS (100 μM, 20 h) causes a significant increase in the mitochondrial reactive species, whereas it does not affect sperm viability, mitochondrial membrane potential, cell reactive oxygen species, GSK3α/β phosphorylation or phosphorylation of PKA substrates. However, BPA (100 μM, 20 h) leads to a decrease in sperm viability, mitochondrial membrane potential, GSK3β phosphorylation and PKA phosphorylation, also causing an increase in cell reactive oxygen species and mitochondrial reactive species. These intracellular effects and signaling pathways inhibited might contribute to explaining the BPA-triggered reduction in pig sperm motility. However, the intracellular pathways and mechanisms triggered by BPS are different, and the BPS-caused reduction in motility can be only partially attributed to an increase in mitochondrial oxidant species.
CSF-Targeted Proteomics Indicate Amyloid-Beta Ratios in Patients with Alzheimer's Dementia Spectrum

Background According to recent studies, amyloid-β (Aβ) isoforms as cerebrospinal fluid (CSF) biomarkers have remarkable predictive value for cognitive decline in the early stages of Alzheimer's disease (AD). Herein, we aimed to investigate the correlations between several targeted proteomics in CSF samples with Aβ ratios and cognitive scores in patients in AD spectrum to search for potential early diagnostic utility. Methods A total of 719 participants were found eligible for inclusion. Patients were then categorized into cognitively normal (CN), mild cognitive impairment (MCI), and AD and underwent an assessment of Aβ and proteomics. Clinical Dementia Rating (CDR), Alzheimer's Disease Assessment Scale (ADAS), and Mini Mental State Exam (MMSE) were used for further cognitive assessment. The Aβ42, Aβ42/Aβ40, and Aβ42/38 ratios were considered as means of comparison to identify those peptides corresponding significantly to these established biomarkers and cognitive scores. The diagnostic utility of the IASNTQSR, VAELEDEK, VVSSIEQK, GDSVVYGLR, EPVAGDAVPGPK, and QETLPSK was assessed. Results All investigated peptides corresponded significantly to Aβ42 in controls. In those with MCI, VAELEDEK and EPVAGDAVPGPK were significantly correlated with Aβ42 (p value < 0.001). Additionally, IASNTQSR, VVSSIEQK, GDSVVYGLR, and QETLPSK were significantly correlated with Aβ42/Aβ40 and Aβ42/38 (p value < 0.001) in this group. This group of peptides similarly corresponded to Aβ ratios in those with AD. Eventually, IASNTQSR, VAELEDEK, and VVSSIEQK were significantly associated with CDR, ADAS-11, and ADAS-13, particularly in MCI group. Conclusion Our research suggests potential early diagnostic and prognostic utilities for certain peptides extracted from CSF-targeted proteomics research. The ethical approval of ADNI is available at ClinicalTrials.gov with Identifier: NCT00106899.
Biased switching in an interacting pair of magnetic particles

The switching dynamics in a pair of coupled magnetic particles is studied numerically via the Landau-Liftshitz-Gilbert form of a set of damped gyromagnetic equations. The effects of dipolar interaction between the particles, anisotropy energy, switching and a small bias field are included. Initial conditions in which the moments are parallel and antiparallel to each other are considered. The presence of a small transverse bias field and inter-particle coupling assists in the switching of a moment. Due to the complicated interplay among different factors, the switching in one particle may lead to a corresponding precession of moment in a neighboring particle. We show that different final configurations may be attained depending on the inter-particle separation and the initial configuration.
α-Linolenic Acid Inhibits RANKL-Induced Osteoclastogenesis In Vitro and Prevents Inflammation In Vivo

Inflammation is an important risk factor for bone-destroying diseases. Our preliminary research found that Zanthoxylum bungeanum seed oil (ZBSO) is abundant in unsaturated fatty acids and could inhibit osteoclastogenesis in receptor activator of nuclear factor κB ligand (RANKL)-induced RAW264.7 cells. However, the key constituents in ZBSO in the prevention of osteoclastogenesis and its possible mechanism related to inflammation are still unclear. Therefore, in this study, oleic acid (OA), linoleic acid (LA), palmitoleic acid (PLA), and alpha-linolenic acid (ALA) in ZBSO, havingthe strongest effect on RANKL-induced osteoclastogenesis, were selected by a tartrate-resistant acid phosphatase (TRAP) staining method. Furthermore, the effects of the selected fatty acids on anti-inflammation and anti-osteoclastogenesis in vitro and in vivo were assessed using RT-qPCR. Among the four major unsaturated fatty acids we tested, ALA displayed the strongest inhibitory effect on osteoclastogenesis. The increased expression of free fatty acid receptor 4 (FFAR4) and β-arrestin2 (βarr2), as well as the decreased expression of nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α), nuclear factor of activated T-cells c1 (NFATc1), and tartrate-resistant acid phosphatase (TRAP) in RAW264.7 cells after ALA treatment were observed. Moreover, in ovariectomized osteoporotic rats with ALA preventive intervention, we found that the expression of TNF-α, interleukin-6 (IL-6), interleukin-1β (IL-1β), NFATc1, and TRAP were decreased, while with the ALA therapeutic intervention, downregulated expression of NF-κB, NFATc1, TRAP, and transforming growth factor beta-activated kinase 1 (TAK1) were noticed. These results indicate that ALA, as the major unsaturated fatty acid in ZBSO, could inhibit RANKL-induced osteoclastogenesis via the FFAR4/βarr2 signaling pathway and could prevent inflammation, suggesting that ZBSO may be a promising potential natural product of unsaturated fatty acids and a dietary supplement for the prevention of osteoclastogenesis and inflammatory diseases.
Excitation Flexibility of On-Antenna Power Combining

In this letter, a design methodology is proposed for on-antenna power combining with flexible input power ratios. Designing multifeed antennas with direct power combining requires weighted driving signals to match the field distribution at the resonant mode of the antenna, imposing serious restrictions on their implementation. To overcome this drawback, we proposed a method to relax the excitation criterion by altering the impedance matching conditions of the multifeed antenna, giving the RF designers a degree of freedom. First, an eigenanalysis method is employed to extract the active impedance values for each port of the antenna. Then, according to a preferred input power distribution, proper impedance matching is built based on the active impedance values. The resulting multifeed antenna resembles the single-feed antenna in terms of the radiation performance with desired driving signals. A series of four-feed slot antennas were fabricated to validate the proposed method. Simulation and measurement results show that under different excitation scenarios the radiation performance of the antenna remains intact, demonstrating the flexibility for on-antenna power combining.
On the numerical solution of the Euler-Lagrange equations

The paper presents a new approach to the numerical solution of the Euler–Lagrange equations based upon the reduction of the problem to a second-order ordinary differential equation (ODE) on the constraint manifold. The algorithm guarantees that the constraints are automatically satisfied and requires a minimal number of evaluations of second-order derivative terms. In fact, second-order derivatives are involved only through the second fundamental tensor of the constraint manifold. This tensor may be computed either explicitly when second derivatives are available or via an approximation procedure with excellent accuracy. Examples are given along with comparisons with state-of-the-art software.
Free-matrices min-projection control for high frequency DC-DC converters

This paper deals with the stabilization of high frequency DC-DC converters. This kind of systems can be modeled as switched affine systems subject to a periodic sampled-data control implementation. The dynamics of these systems is expressed using the δ-operator in order to cope with high frequency switching control constraints. The novelties of this paper, first, relies on the formulation of a free-matrices based min-projection control law, that allows the selection of the mode to be activated, based on the knowledge of the state variables. Second, the stability theorem, expressed in terms of a tractable optimization problem, that guarantees a practical stability result to a set and delivers the optimal control law that minimizes the volume of this one. The method is then illustrated through the control of a high frequency boost converter.
Efficacy of Saccharothrix algeriensis NRRL B-24137 to suppress Fusarium oxysporum f.sp. vasinfectum induced wilt disease in cotton

Fusarium cotton wilt is a devastating disease of the cotton crop throughout the world, caused by Fusarium oxysporum f.sp. vasinfectum (FOV). Chemical control has many side effects, so, biological controls have been widely used for the management of Fusarium wilt. This study aimed to investigate the possible use of an actinomycetes Saccharothrix algeriensis (SA) NRRL B-24137 to control FOV. To access in-vitro anti-Fusarium ability of SA NRRL B-24137, dual culture assay, spore germination and seed germination tests were carried out. Following in-vitro investigations, several pot tests in a greenhouse environment were used to evaluate the biological control potential of SA NRRL B-24137 against FOV. Dual culture assay and spore germination revealed that SA NRRL B-24137 showed significant anti-Fusarium activity.During spore germination 87.77% inhibition of spore germination were observed. In pot experiments, SA NRRL B-24137 primed cotton seeds resulted in a 74.0% reduction in disease incidence. In soil there was a significant reduction in FOV spores in the presence of SA NRRL B-24137. Positive correlation was also observed on different concentrations of SA NRRL B-24137 towards FOV reduction. The results of this study showed that SA NRRL B-24137 has the potential to be employed as a biocontrol agent against Fusarium cotton wilt, improving cotton growth characteristics and yield.
Improving the Robustness of Point Convolution on k-Nearest Neighbor Neighborhoods with a Viewpoint-Invariant Coordinate Transform

Recently, there is significant interest in performing convolution over irregularly sampled point clouds. Point clouds are very different from raster images, in that one cannot have a regular sampling grid on point clouds, which makes robustness under irregular neighborhoods an important issue. Especially, the k-nearest neighbor (kNN) neighborhood presents challenges for generalization because the location of the neighbors can be very different between training and testing times. In order to improve the robustness to different neighborhood samplings, this paper proposes a novel viewpoint-invariant coordinate transform as the input to the weight-generating function for point convolution, in addition to the regular 3D coordinates. This allows us to feed the network with non-invariant, scale-invariant and scale+rotation-invariant coordinates simultaneously, so that the network can learn which to include in the convolution function automatically. Empirically, we demonstrate that this effectively improves the performance of point cloud convolutions on the SemanticKITTI and ScanNet datasets, as well as the robustness to significant test-time downsampling, which can substantially change the distance of neighbors in a kNN neighborhood. Experimentally, among pure point-based approaches, we achieve comparable semantic segmentation performance with a comparable point-based convolution framework KPConv on SemanticKITTI and ScanNet, yet is significantly more efficient by virtue of using a kNN neighborhood instead of an ϵ-ball.
Targeted Therapy of Severe Infections Caused by Staphylococcus aureus in Critically Ill Adult Patients: A Multidisciplinary Proposal of Therapeutic Algorithms Based on Real-World Evidence

(1) Introduction: To develop evidence-based algorithms for targeted antibiotic therapy of infections caused by Staphylococcus aureus in critically ill adult patients. (2) Methods: A multidisciplinary team of four experts had several rounds of assessment for developing algorithms concerning targeted antimicrobial therapy of severe infections caused by Staphylococcus aureus in critically ill patients. The literature search was performed by a researcher on PubMed-MEDLINE (until August 2022) to provide evidence for supporting therapeutic choices. Quality and strength of evidence was established according to a hierarchical scale of the study design. Two different algorithms were created, one for methicillin-susceptible Staphylococcus aureus (MSSA) and the other for methicillin-resistant Staphylococcus aureus (MRSA). The therapeutic options were categorized for each different site of infection and were selected also on the basis of pharmacokinetic/pharmacodynamic features. (3) Results: Cefazolin or oxacillin were the agents proposed for all of the different types of severe MSSA infections. The proposed targeted therapies for severe MRSA infections were different according to the infection site: daptomycin plus fosfomycin or ceftaroline or ceftobiprole for bloodstream infections, infective endocarditis, and/or infections associated with intracardiac/intravascular devices; ceftaroline or ceftobiprole for community-acquired pneumonia; linezolid alone or plus fosfomycin for infection-related ventilator-associated complications or for central nervous system infections; daptomycin alone or plus clindamycin for necrotizing skin and soft tissue infections. (4) Conclusions: We are confident that targeted therapies based on scientific evidence and optimization of the pharmacokinetic/pharmacodynamic features of antibiotic monotherapy or combo therapy may represent valuable strategies for treating MSSA and MRSA infections.
Latent Fault Detection and Diagnosis for Control Rods Drive Mechanisms in Nuclear Power Reactor Based on GRU-AE

Latent fault detection and diagnosis (LFDD) for equipment are crucial for safety and reliability in nuclear power reactors (NPRs). In this article, a high accuracy LFDD method combining gate recurrent unit-based autoencoder (GRU-AE) and random forest (RF) was proposed for control rod drive mechanisms (CRDM) in pressurized water reactors (PWRs). The movement sequences of the CRDM coils’ current reflecting the degradation of CRDM were assumed as time series and taken by the sliding window. GRU-AE, a network containing an encoder and decoder, was applied to build the health operating data reconstruction model. The labeled abnormal data were generated by adding the typical current waveforms with a Gaussian noise sequence. The latent fault could be detected by feeding online datasets into the well-trained model because of reconstruction error sensitivity to a slight/minor deflection. And then, RF was used as a classifier to diagnose the types of abnormalities. The results demonstrate that combining the GRU-AE and RF can realize high-accuracy detection on real-world imbalanced datasets.
On the Monotonicity of Optimal Transportation Plans

Abstract We obtain analytical properties of the maps that give optimal transportation plans for the L 2 -Wasserstein distance. We take advantage of the monotonicity of such optimal transportation plans to discuss their measurability and continuity. As a main result of independent interest we obtain the a.e. continuity of monotone (in the sense of Zarantonello) operators.
Full Optoelectronic Simulation of Lead-Free Perovskite/Organic Tandem Solar Cells

Organic and perovskite semiconductor materials are considered an interesting combination thanks to their similar processing technologies and band gap tunability. Here, we present the design and analysis of perovskite/organic tandem solar cells (TSCs) by using a full optoelectronic simulator (SETFOS). A wide band gap lead-free ASnI2Br perovskite top subcell is utilized in conjunction with a narrow band gap DPPEZnP-TBO:PC61BM heterojunction organic bottom subcell to form the tandem configuration. The top and bottom cells were designed according to previous experimental work keeping the same materials and physical parameters. The calibration of the two cells regarding simulation and experimental data shows very good agreement, implying the validation of the simulation process. Accordingly, the two cells are combined to develop a 2T tandem cell. Further, upon optimizing the thickness of the front and rear subcells, a current matching condition is satisfied for which the proposed perovskite/organic TSC achieves an efficiency of 13.32%, Jsc of 13.74 mA/cm2, and Voc of 1.486 V. On the other hand, when optimizing the tandem by utilizing full optoelectronic simulation, the tandem shows a higher efficiency of about 14%, although it achieves a decreased Jsc of 12.27 mA/cm2. The study shows that the efficiency can be further improved when concurrently optimizing the various tandem layers by global optimization routines. Furthermore, the impact of defects is demonstrated to highlight other possible routes to improve efficiency. The current simulation study can provide a physical understanding and potential directions for further efficiency improvement for lead-free perovskite/organic TSC.
Arterial Stiffness as a Predictor of the Index of Atherosclerotic Cardiovascular Disease in Hypertensive Patients

Objective: The aim of this study was to evaluate the predictive value of carotid-femoral pulse wave velocity (cfPWV) and cardiovascular disease in the hypertensive population in China and to determine the specific cfPWV cut-off value for assessing future cardiovascular disease (CVD) risk. Methods: This cross-sectional study included 630 hospital patients with primary hypertension and multiple cardiovascular risk factors or complications involving damage to clinical target organs. The study was conducted between July 2007 and October 2008. Atherosclerotic cardiovascular disease (ASCVD) risk calculations were computed according to criteria presented by the American College of Cardiology and the American Heart Association. Patients were stratified by a predefined risk threshold of 10% and divided into two groups: ASCVD ≥ 10% or ASCVD < 10%. cfPWV was used as a marker of arterial stiffness. A receiver operating characteristics (ROC) curve was applied to establish the optimal cfPWV cut-off point to differentiate between participants with and without ASCVD risk. Results: In the study cohort of 630 patients (age 63.55.2 ± 8.6 years, 61.7% male) with primary hypertension, the pressure indices (augmented pressure, augmentation index [AIx], aortic pulse pressure, aortic systolic pressure [SBP]) and Framingham Risk Scores (FRS) were greater in females than in males (p < 0.001); ASCVD risk scores and peripheral diastolic pressure (DBP) were higher in males (p < 0.05). All hemodynamic indices showed a significant positive correlation with ASCVD risk scores and FRS; AIx was not correlated with ASCVD risk scores. In multivariate logistic analysis, cfPWV was significantly associated with ASCVD risk (OR: 1.324, 95% confidence interval: 1.119–1.565, p < 0.001) after adjusting for age, gender, smoking, body mass index, total cholesterol, fasting blood glucose, antihypertensive treatment, statin treatment, and DBP. In the ROC analysis, the area under the curve was 0.758 and 0.672 for cfPWV and aortic SBP (p < 0.001 and p < 0.001, respectively); the optimal critical value of cfPWV and aortic SBP was 12.45 m/s (sensitivity 63.2%, specificity 77.8%) and 124.5 mmHg (sensitivity 63.9%, specificity 65.3%). Conclusions: cfPWV is significantly correlated with the risk of ASCVD. The best cut-off value of cfPWV for assessing future CVD risk in the hypertensive population in China is 12.45 m/s.
Efficacy of Specific Trunk Exercises in the Balance Dysfunction of Patients with Parkinson’s Disease: A Systematic Review and Meta-Analysis

Parkinson’s disease (PD) is a neurodegenerative pathology classified as a movement disorder. Physical exercise within a physiotherapy program is an important element to improve postural stability, balance and mobility in order to reduce falls in people with PD. The aim of this work was to determine the efficacy of specific balance and trunk mobility exercises, as well as their benefits for and effects on patients with idiopathic PD. A systematic review and meta-analysis was conducted according to PRISMA standards. The search was performed in five databases: Cochrane Library, SciELO, PEDro, Scopus and PubMed, in February 2022 with the following descriptors: Parkinson’s disease, trunk, exercise, therapy and physical therapy. The inclusion criteria were randomized controlled trials (RCTs) over the last ten years. A meta-analysis on static and dynamic balance was conducted with the software Review Manager. Nine articles met the objectives and inclusion criteria, with a total of 240 participants. The trials had moderate methodological quality according to the PEDro scale. The studies included differed with regard to intervention protocol and outcome measures. Finally, eight studies were included in a quantitative analysis in which it was shown that trunk-specific exercises interventions did not significantly improve static balance (SMD = −0.10, 95% CI = −0.29, 0.08; p = 0.28) or dynamic balance (SMD = 0.64 95% CI = −0.24, 1.52; p = 0.15). However, significant differences were found in static balance measured subjectively using the Berg Balance Scale (SMD = −0.52, 95% CI = −1.01, −0.02; p = 0.04). Although some differences were not significant, the studies included in this systematic review consider that specific trunk exercises or balance training combined with muscle strengthening in patients with idiopathic PD should be a complement to pharmacological treatment for improving balance dysfunction and postural instability, preventing falls and promoting wellness.
Morphix-NLP Live CD Manual

A shift lever for an automotive transmission includes first and second shafts. The first shaft has a hole and the second shaft partially extends into the hole so as to be spaced from the first shaft by a resilient member preventing transmission of vibrations between the shafts. In a method of manufacturing the shift lever, plastic rubber is provided in the spacing between the first and second shafts. The rubber is vulcanized so as to have a predetermined resiliency and adhere to both of the first and second shafts.