Miracle-dz/UniFAR-FTUs huggingface dataset:
Across‐speaker and within‐speaker variability of British English sibilant spectral characteristics

Testing hypotheses regarding the potential as phoneme discriminators of certain properties of “physical” and “auditorily transformed” sibilant spectra [A. Bladon and F. Seitz, J. Acoust. Soc. Am. Suppl. 1 80, S19 (1986)], the present study draws on a database of 20 male and 20 female talkers, containing over 2000 tokens of /s/, /∫/, /z/, and /ȝ/ in a variety of phonetic contexts and speaking styles. Two automatic parameter extraction routines were used to obtain measurements, for each token, of physical and auditorily scaled values of the main spectral peak, gradients of the leading and trailing spectral edges, and bandwidth of the peak. Especially in females' productions of the apicals, large and characteristic variations in these parameters were observed as correlates of individual talker, phonetic context, and style. Overviews of the envelopes of physical and auditory variation are given; based upon this knowledge, a speaker‐adaptive strategy for discrimination of British English sibilants is proposed.
Patient-Reported Functional Impairment Due to Hearing Loss and Tinnitus After Cisplatin-Based Chemotherapy

PURPOSE Cisplatin is widely used and highly ototoxic, but patient-reported functional impairment because of cisplatin-related hearing loss (HL) and tinnitus has not been comprehensively evaluated. PATIENTS AND METHODS Testicular cancer survivors (TCS) given first-line cisplatin-based chemotherapy completed validated questionnaires, including the Hearing Handicap Inventory for Adults (HHIA) and Tinnitus Primary Function Questionnaire (TPFQ), each of which quantifies toxicity-specific functional impairment. Spearman correlations evaluated associations between HL and tinnitus severity and level of functional handicap quantified with the HHIA and TPFQ, respectively. Associations between HL or tinnitus and five prespecified adverse health outcomes (cognitive dysfunction, fatigue, depression, anxiety, and overall health) were evaluated. RESULTS HL and tinnitus affected 137 (56.4%) and 147 (60.5%) of 243 TCS, respectively. Hearing aids were used by 10% TCS (14/137). Of TCS with HL, 35.8% reported clinically significant functional impairment. Severe HHIA-assessed functional impairment was associated with cognitive dysfunction (odds ratio [OR], 10.62; P < .001), fatigue (OR, 5.48; P = .003), and worse overall health (OR, 0.19; P = .012). Significant relationships existed between HL severity and HHIA score, and tinnitus severity and TPFQ score (P < .0001 each). TCS with either greater hearing difficulty or more severe tinnitus were more likely to report cognitive dysfunction (OR, 5.52; P = .002; and OR, 2.56; P = .05), fatigue (OR, 6.18; P < .001; and OR, 4.04; P < .001), depression (OR, 3.93; P < .01; and OR, 3.83; P < .01), and lower overall health (OR, 0.39; P = .03; and OR, 0.46; P = .02, respectively). CONCLUSION One in three TCS with HL report clinically significant functional impairment. Follow-up of cisplatin-treated survivors should include routine assessment for HL and tinnitus. Use of the HHIA and TPFQ permit risk stratification and referral to audiologists as needed, since HL adversely affects functional status and is the single largest modifiable risk factor for cognitive decline and dementia in the general population.
Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity

An increasing number of commonly prescribed drugs are known to interfere with mitochondrial function, which is associated with almost half of all Food and Drug Administration black box warnings, a variety of drug withdrawals, and attrition of drug candidates. This can mainly be attributed to a historic lack of sensitive and specific assays to identify the mechanisms underlying mitochondrial toxicity during drug development. In the last decade, a better understanding of drug-induced mitochondrial dysfunction has been achieved by network-based and structure-based systems pharmacological approaches. Here, we propose the implementation of a tiered systems pharmacology approach to detect adverse mitochondrial drug effects during preclinical drug development, which is based on a toolset developed to study inherited mitochondrial disease. This includes phenotypic characterization, profiling of key metabolic alterations, mechanistic studies, and functional in vitro and in vivo studies. Combined with binding pocket similarity comparisons and bottom-up as well as top-down metabolic network modeling, this tiered approach enables identification of mechanisms underlying drug-induced mitochondrial dysfunction. After validation of these off-target mechanisms, drug candidates can be adjusted to minimize mitochondrial activity. Implementing such a tiered systems pharmacology approach could lead to a more efficient drug development trajectory due to lower drug attrition rates and ultimately contribute to the development of safer drugs. Significance Statement Many commonly prescribed drugs adversely affect mitochondrial function, which can be detected using phenotypic assays. However, these methods provide only limited insight into the underlying mechanisms. In recent years, a better understanding of drug-induced mitochondrial dysfunction has been achieved by network-based and structure-based system pharmacological approaches. Their implementation in preclinical drug development could reduce the number of drug failures, contributing to safer drug design.
Statistical Mechanics of Dense Ionized Matter. I. Equilibrium Properties of the Classical One-Component Plasma

The equilibrium properties of a classical one-component plasma, in a uniform background of opposite charge, are computed for systems of various sizes by the Monte Carlo method of Metropolis et al. Following the work of Brush, Sahlin, and Telier, the periodicity of the system is accounted for by replacing the long-range Coulomb potential by an effective Ewald sum. Thermodynamic properties are computed over the whole density range of the fluid phase of the system, and their N dependence is carefully investigated. A semiempirical equation of state is proposed from which all thermodynamic properties can be easily derived. Quantum corrections to these properties are calculated to first order in the Wigner expansion. Radial distribution functions, direct-correlation functions, and structure factors at various densities are tabulated. It is shown that at all densities, the direct-correlation function tends rapidly towards its Debye-Huckel form, in contrast to the radial distribution function. The behavior of the structure factor at small wave vectors is also shown to be in good agreement with the Debye-Huckel predictions at all densities.
Electronic Medical Record System Use and Determinants in Ethiopia: Systematic Review and Meta-Analysis

Background The strategic plan of the Ethiopian Ministry of Health recommends an electronic medical record (EMR) system to enhance health care delivery and streamline data systems. However, only a few exhaustive systematic reviews and meta-analyses have been conducted on the degree of EMR use in Ethiopia and the factors influencing success. This will emphasize the factors that make EMR effective and increase awareness of its widespread use among future implementers in Ethiopia. Objective This study aims to determine the pooled estimate of EMR use and success determinants among health professionals in Ethiopia. Methods We developed a protocol and searched PubMed, Web of Sciences, African Journals OnLine, Embase, MEDLINE, and Scopus to identify relevant studies. To assess the quality of each included study, we used the Joanna Briggs Institute quality assessment tool using 9 criteria. The applicable data were extracted using Microsoft Excel 2019, and the data were then analyzed using Stata software (version 11; StataCorp). The presence of total heterogeneity across included studies was calculated using the index of heterogeneity I2 statistics. The pooled size of EMR use was estimated using a random effect model with a 95% CI. Results After reviewing 11,026 research papers, 5 papers with a combined total of 2439 health workers were included in the evaluation and meta-analysis. The pooled estimate of EMR usage in Ethiopia was 51.85% (95% CI 37.14%-66.55%). The subgroup study found that the northern Ethiopian region had the greatest EMR utilization rate (58.75%) and that higher (54.99%) utilization was also seen in publications published after 2016. Age groups <30 years, access to an EMR manual, EMR-related training, and managerial support were identified factors associated with EMR use among health workers. Conclusions The use of EMR systems in Ethiopia is relatively low. Belonging to a young age group, accessing an EMR manual, receiving EMR-related training, and managerial support were identified as factors associated with EMR use among health workers. As a result, to increase the use of EMRs by health care providers, it is essential to provide management support and an EMR training program and make the EMR manual accessible to health professionals.
Temporally directed attention in the detection and discrimination of auditory pattern components

Thresholds for detection and frequency discrimination were determined for tones that occurred at unexpected temporal locations within 12‐tone sequences. Expectancies were established by repeated presentations of a standard pattern on each trial. Temporal deviations were introduced in comparison patterns by advancing or delaying the onset of a single ‘‘target’’ tone while maintaining its serial position within the pattern. Rhythmic patterns consisting of 350‐ and 150‐ms intertone intervals were used to allow for a large range of temporal displacements. Thresholds were determined for target tones that were advanced (‘‘early’’ targets) or delayed (‘‘late’’ targets) by various degrees. Thresholds for displaced targets were elevated with respect to nondisplaced targets for both detection and discrimination. However, for most listeners, there was little or no effect of temporal displacement on detection except when targets were advanced by 200 ms or more. Temporal deviations had more consistent effects on frequ.
The spectral flux distribution of the candidate BL Lacertae object 1218 + 304 /identically equal to 2A 1219 + 305/

A break in the optical-infrared spectrum (0.36--3.5 mm) of the X-ray-discovered candidate BL Lac object 1218+304 has been observed at a wavelength of about 1 mm. Two possible causes of the break are considered. One is that it is a high-frequency break in a synchrotron spectrum, resulting from radiaton losses. The other is that the observed spectrum is a composite of a power-law spectrum and a galaxian spectrum. The radio through X-ray spectral flux distributions of the two X-ray-discovered BL Lac objects, 1218+304 and 2155-304, are quite similar. If the radio, infrared, and optical radiation have a common origin in an inhomogeneous synchrotron source, then the observed slope of the X-ray spectrum makes it unlikely that the X-radiation is produced by Compton scattering. The observed soft X-radiation from BL Lac objects is better explained as the high-frequency tail of a synchrotron spectrum. The low radio:optical spectral-flux ratios of 1284+304 and 2155-304 suggest that this ratio may be inversely related to the break frequency for BL Lac objects. In that case, there may be BL Lac objects which have spectral breaks in the ultraviolet, flat optical spectra, and very weak radio emission. Such objects would most easily be discovered through themore » X-ray emission. « less
Factors influencing kidney transplantation rates: a study from the ERA Registry

ABSTRACT Background Large international differences exist in kidney transplantation (KT) rates. We aimed to investigate which factors may explain the total, deceased donor and living donor KT rates over the last decade. Methods KT experts from 39 European countries completed the Kidney Transplantation Rate Survey on measures and barriers and their potential effect on the KT rate in their country. In the analyses, countries were divided into low, middle and high KT rate countries based on the KT rate at the start of study period in 2010. Results Experts from low KT rate countries reported more frequently that they had taken measures regarding staff, equipment and facilities to increase the total KT rate compared with middle and high KT rate countries. For donor type–specific KT, the largest international differences in measures taken were reported for deceased donor KT, with middle and high KT rate countries taking more measures, such as the use of expanded criteria donor kidneys, the presence of transplantation coordinators and (inter)national exchange of donor kidneys. Once a measure was taken, experts’ opinion on its success was similar across the low, middle and high KT rate countries. Experts from low KT rate countries more often reported potential barriers, such as patients’ lack of knowledge and distrust in the healthcare system. Conclusions Particularly in low KT rate countries, the KT rate might be stimulated by optimizing staff, equipment and facilities. In addition, all countries may benefit from measures specific to deceased and living donors.
The Fission Yeast Mating-Type Switching Motto: “One-for-Two” and “Two-for-One”

Schizosaccharomyces pombe is an ascomycete fungus that divides by medial fission; it is thus commonly referred to as fission yeast, as opposed to the distantly related budding yeast Saccharomyces cerevisiae. The reproductive lifestyle of S. pombe relies on an efficient genetic sex determination system generating a 1:1 sex ratio and using alternating haploid/diploid phases in response to environmental conditions. SUMMARY Schizosaccharomyces pombe is an ascomycete fungus that divides by medial fission; it is thus commonly referred to as fission yeast, as opposed to the distantly related budding yeast Saccharomyces cerevisiae. The reproductive lifestyle of S. pombe relies on an efficient genetic sex determination system generating a 1:1 sex ratio and using alternating haploid/diploid phases in response to environmental conditions. In this review, we address how one haploid cell manages to generate two sister cells with opposite mating types, a prerequisite to conjugation and meiosis. This mating-type switching process depends on two highly efficient consecutive asymmetric cell divisions that rely on DNA replication, repair, and recombination as well as the structure and components of heterochromatin. We pay special attention to the intimate interplay between the genetic and epigenetic partners involved in this process to underscore the importance of basic research and its profound implication for a better understanding of chromatin biology.
Electric current in dc surface flashover in vacuum

Dielectric surface flashover in vacuum is characterized by a three-phase development, as shown by current measurements covering the range from 10−4 to 100 A, assisted by x-ray emission measurements, high speed photography, and time-resolved spectroscopy. Further information is gained from a comparison of the flashover dynamics at 77 and 300 K. Phase one comprises a fast (several nanoseconds) buildup of a saturated secondary electron avalanche reaching current levels of 10 to 100 mA. Phase two is associated with a slow current amplification, with a duration on the order of 100 ns, reaching currents in the ampere level. The final phase three is characterized again by a fast (nanoseconds) current rise up to the impedance-limited current on the order of 100 A in this specific apparatus. The development during phase two and three is described by a zero-dimensional model, where electron-induced outgassing leads to a Townsend-like gas discharge above the surface. The feedback mechanism towards a self-sustained d.
Turbulence: Space‐time statistical properties and behavior in supersonic flows

Following a scientific cooperation beginning in 1954 with L. S. G. Kovasznay, and in his memory, in this paper is presented a survey of two of the main areas of research to which he contributed: (1) turbulence properties deduced through statistical conditional sampling and space‐time measurements of correlations and contingencies; these include celerities, optimum correlations, memories, and coherent structures; and (2) the study of turbulence in supersonic flows initiated by Kovasznay; this include the use of mass‐weighted averages, decrease of turbulence in expansion, increase in compression, strong Reynolds analogy extension, and temperature–velocity correlation conservation.
Gender differences in motor and non-motor symptoms in individuals with mild-moderate Parkinson’s disease

Background Parkinson’s disease (PD) affects both men and women with documented gender differences across functional domains, with findings varying among reports. Knowledge regarding gender differences in PD for different geographic locations is important for further understanding of the disease and for developing personalized gender-specific PD assessment tools and therapies. Objective This study aimed to examine gender differences in PD-related motor, motor-cognitive, cognitive, and psychosocial function in people with PD from the southern United States (US). Methods 199 (127 men and 72 women; M age: 69.08±8.94) individuals with mild-moderate idiopathic PD (Hoehn &Yahr (H&Y) Median = 2, stages I-III) from a large metro area in the southeastern US were included in this retrospective, cross-sectional study. Motor, motor-cognitive, cognitive, and psychosocial data were obtained using standardized and validated clinical tests. Univariate analyses were performed, adjusting for age and housing type. Results After adjustment for age, housing, PD duration and fall rate, men exhibited statistically significantly greater motor (Movement Disorders Society (MDS)-Unified Parkinson Disease Rating Scale (UPDRS)-II) and non-motor (MDS-UPDRS-I) impact of PD, and more severe motor signs (MDS-UPDRS-III). Men exhibited worse PD-specific health-related quality of life related to mobility, activities of daily living, emotional well-being, cognitive impairment, communication, and more depressive symptoms. Men performed worse on a subtraction working memory task. Women had slower fast gait speed. Conclusions In the southeastern United States, men may experience worse PD-related quality of life and more depression than women. Many non-motor and motor variables that are not PD specific show no differences between genders in this cohort. These findings can contribute to the development of gender-sensitive assessment and rehabilitation policies and protocols for people with PD.
SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 9 and 13 repress BLADE-ON-PETIOLE 1 and 2 directly to promote adult leaf morphology in Arabidopsis

Abstract The juvenile-to-adult phase transition during vegetative development is a critical decision point in a plant’s life cycle. This transition is mediated by a decline in levels of miR156/157 and an increase in the activities of its direct targets, SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) proteins. In Arabidopsis, the juvenile-to-adult transition is characterized by an increase in the length to width ratio of the leaf blade (a change in the distal region of a leaf), but what mediates this change in lamina shape is not known. Here, we show that ectopic expression of SPL9 and SPL13 produces enlarged and elongated leaves, resembling leaves from the blade-on-petiole1 (bop1) bop2 double mutant. The expression of BOP1/BOP2 is down-regulated in successive leaves, correlating with the amount of miR156 and antagonistic to the expression of SPL9 and SPL13 in leaves. SPL9 and SPL13 bind to the promoters of BOP1/BOP2 directly to repress their expression, resulting in delayed establishment of proliferative regions in leaves, which promotes more blade outgrowth (the distal region of a leaf) and suppresses petiole development (the proximal region of a leaf). Our results reveal a mechanism for leaf development along the proximal–distal axis, a heteroblastic character between juvenile leaves and adult leaves.
Psychosocial health in adolescent unmarried motherhood in rural Uganda: Implications for community-based collaborative mental health education, and empowerment strategies in the prevention of depression and suicide

Teenage pregnancy rates in Uganda are among the highest in sub-Saharan Africa. Child marriage is often the result of unmarried teenage pregnancy and is recognised by Uganda's government as a form of sexual violence and an outcome of inequality. However, unmarried motherhood incurs stigma and shame within traditionally living rural communities. Using co-produced Open Space and ethnographic methods, we examined the psychosocial impact of unmarried motherhood on girls and their communities, and explored problem-solving with key local stakeholders. Findings indicate that girls experience extreme stress, social exclusion and rejection by their families, and experience bereavement from school expulsion and the loss of their career aspirations. Depressive symptoms and suicidal behaviour are reportedly not uncommon among this population group. Community and family efforts to promote marriage for these mothers to avoid social stigma increased the mothers’ feelings of depression, whereas mothers who became independent appeared to fare better psychologically. Community members and local stakeholders demonstrated a willingness to act locally to reduce the negative impacts of unmarried motherhood but lacked knowledge and support resources. Our findings indicate that mental health promotion for teenage mothers is likely to be better served through empowerment strategies rather than marriage and, in a context of poor mental health service access, there is a substantial role for community mobilisation and the promotion of self-help strategies to support teenage mothers. This study raises important points regarding different community understandings of depression and indicates collaboration between professionals and communities for a values-based approach.
Optimization of Sound Coding Strategies to Make Singing Music More Accessible for Cochlear Implant Users

Cochlear implants (CIs) are implantable medical devices that can partially restore hearing to people suffering from profound sensorineural hearing loss. While these devices provide good speech understanding in quiet, many CI users face difficulties when listening to music. Reasons include poor spatial specificity of electric stimulation, limited transmission of spectral and temporal fine structure of acoustic signals, and restrictions in the dynamic range that can be conveyed via electric stimulation of the auditory nerve. The coding strategies currently used in CIs are typically designed for speech rather than music. This work investigates the optimization of CI coding strategies to make singing music more accessible to CI users. The aim is to reduce the spectral complexity of music by selecting fewer bands for stimulation, attenuating the background instruments by strengthening a noise reduction algorithm, and optimizing the electric dynamic range through a back-end compressor. The optimizations were evaluated through both objective and perceptual measures of speech understanding and melody identification of singing voice with and without background instruments, as well as music appreciation questionnaires. Consistent with the objective measures, results gathered from the perceptual evaluations indicated that reducing the number of selected bands and optimizing the electric dynamic range significantly improved speech understanding in music. Moreover, results obtained from questionnaires show that the new music back-end compressor significantly improved music enjoyment. These results have potential as a new CI program for improved singing music perception.