Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk and outcome of second primary malignancy in patients with classical Hodgkin lymphoma

Background: Hodgkin lymphoma survivors demonstrated increased risk of secondary primary malignancies (SPMs), but comprehensive analysis of the risk and outcome of SPMs in classical Hodgkin lymphoma (cHL) patients has not yet been reported. Methods: Patients with cHL from 1975 to 2017 were identified from the Surveillance, Epidemiology and End Results (SEER) database. Standardized incidence ratios were calculated for the risk of solid and hematologic SPMs in cHL patients compared to the general population. The outcome of cHL patients developing SPMs were assessed by performing survival, competing risks regression, and cox proportional regression analyses. Results: In a follow-up of 26,493 cHL survivors for 365,156 person years, 3866 (14.59%) secondary cancers were identified, with an standardized incidence ratio of 2.09 (95% CI: 2.02–2.15). The increased risk was still notable after follow-up of 10 years or more, and the risk is more pronounced for patients with female gender, younger age, advanced stage, chemotherapy, and radiation therapy. The overall survival is worse for cHL patients with SPMs after 11 years of follow-up (P < .0001). The main cause of death for cHL patients with SPMs is not cHL but other causes including SPMs. Multivariate Cox regression analysis confirmed SPMs as an independently adverse prognostic factor for cHL survivors (hazard ratio, 1.13; 95% CI, 1.05–1.21, P = .001). Conclusions: There is a significantly increased risk of developing SPMs for cHL survivors. The overall survival is worse for cHL patients and SPMs is an independent prognostic factor for cHL.
A Plagiarism Paperdemic - Plagiarism in infection journals in the era of COVID-19

Abstract Background: The COVID-19 pandemic has caused drastic changes in the publishing framework in order to quickly review and publish vital information during this public health emergency. The quality of the academic work being published may have been compromised. One area of concern is plagiarism, where the work of others is directly copied and represented as ones own. The purpose of this study is to determine the presence of plagiarism in infection journals in papers relating to the COVID-19 pandemic. Methods: Consecutively occurring original research or reviews relating to the COVID-19 pandemic, published in infection journals as ranked by SCOPUS Journal finder were collected. Each manuscript was optimized and uploaded to the Turnitin program. Similarity reports were then manually checked for true plagiarism within the text, where any sentence with more than 80% copying was deemed plagiarised. Results: A total of 310 papers were analyzed in this cross-sectional study. Papers from a total of 23 journals among 4 quartiles were examined. Of the papers we examined, 41.6% were deemed plagiarised (n=129). Among the plagiarised papers, the average number of copied sentences was 5.42+/-9.18. The highest recorded similarity report was 60%, and the highest number of copied sentences was 85. Plagiarism was higher in papers published in the year 2020. The most problematic area in the manuscripts was the discussion section. Self plagiarism was identified in 31 papers. Average time to judge all manuscripts was 2.45+/-3.09. Among all the plagiarized papers 72% belonged to papers where the similarity report was less than 15% (n=93). Papers published from core anglosphere speaking countries were not associated with higher rates of plagiarism. No significant differences were found with regards to plagiarism events among the quartiles. Conclusion: Plagiarism is prevalent in COVID19 related publications in infection journals among various quartiles. It is not enough to rely only on similarity reports. Such reports must be accompanied by manual curation of the results with an appropriate threshold to be able to appropriately determine if plagiarism is occurring. The majority of plagiarism is occurring in reports of less than 15% similarity, and this is a blind spot. Incorporating a manual judge could save future time in avoiding retractions and improving the quality of papers in these journals.
Data Warehouse Performance Efficiency using Snowflake and Bitmap Index

Designing a Data warehouse is the main mission done by DBA; Testing the data warehouse performance efficiency is also done while going to production. Actually, hardware has developed in term of memory volume, speed and storage, but for the specialists, the objec-tive is still to minimize the execution time and the storage space. The paper shows that using bitmap index and partitioned fact tables in big data warehouses volumes based on a snowflake schema is advantageous based on query execution time.
In the light of black holes - Accretion discs, coronae and jets around accreting black holes

My research is about studying the radiation (essentially hard X-rays) coming from accreting black holes (AGNs and X-ray binaries) with the aim of extracting information about the physical conditions in their immediate vicinity. The main questions I am trying to answer are: What is the structure and geometry of the accreting material close to the black hole ? How does it changes with mass accretion rate ? What is the nature of the connection between accretion processes and the formation of jets observed in those systems ? My approach is centred on a detailed comparison of the observations with the predictions of various models. I present the efforts I have been pursuing for almost ten years in order to develop powerful numerical simulation tools for radiative transfer in the hot X-ray emitting plasma surrounding compact objects. I show how these tools have been used to model the high energy continuum and variability of accreting black holes and constrain the structure of the accretion flow. I also present results based on the analysis and interpretation of observations performed with space-based X-ray and gamma-ray telescopes such as XMM and INTEGRAL as well as simultaneous multi-wavelength observations.
I believe what I see: Impact of attire and academic degree on evaluation of personality traits of a politician

BACKGROUND The image of a politician primes people to judge his/her personality traits. Voters are looking for such qualities as honesty, intelligence, friendliness, sincerity, and trustworthiness. Most studies, however, concentrate on the evaluation of faces, and only some take into account the candidate’s attire. PARTICIPANTS AND PROCEDURE The research included 320 participants between 18 and 78 years. It aimed to assess whether the parliamentary candidate’s attire affects voters’ evaluation of his personality traits. A description of his program was also presented to determine whether it affected the candidate’s evaluation. Participants observed four versions of a fictional candidate’s election materials: the candidate dressed in a formal suit or dressed casually and dressed formally or casually but bearing a doctor’s degree. We used a self-constructed questionnaire to evaluate selected traits of the candidate’s character. RESULTS The findings revealed that participants believed an individual in casual wear to be more active, attractive, open to people and the world, friendly, honest, and reliable, and only more smart, and effective while dressed formally. Also, the academic degree proved to be of importance. Accordingly, the same person with a doctorate was additionally evaluated as competent, responsible when dressed casually, and responsible when wearing a suit. It confirms the assumption that the informal dress and academic degree are most influential. The program description proved to be of no significance. CONCLUSIONS Our study shows that the way the candidate was dressed affected the evaluation of his personality characteristics. The participants attributed the casually dressed candidate the traits expected from a politician.
The Effect of Instructional Pacing on Skill Acquisition and Maintenance for Children with Developmental Disabilities

Discrete trial training is an instructional method based on the principles of applied behaviour analysis where skills are taught in discrete units. This instructional method has empirical support for increasing skills among children with developmental disabilities. Instructional pacing has been identified as a key variable in discrete trial training that may enhance skill acquisition. Instructional pacing is the rate at which each individual presentation of the instructional target occurs. Research examining the effects of varying the pace of instruction has produced inconsistent findings. This study sought to examine the effects of five paces of instruction on skill acquisition for young learners. Pace was manipulated by varying the interstimulus interval. Two children with a diagnosis of autism spectrum disorder and one with Down syndrome participated in the study. Instructional targets, the specific behavioural skills to be taught to the participants, included: tact: (expressive labelling—i.e., responding to a particular object or event or property of an object or event), listener responding (responding to an instruction), and intraverbal skills (responding to social questions). In contrast to earlier research, participants achieved mastery by demonstrating a previously determined level of skill without prompting in the fewest number of trials in the slowest pace condition. The pace of instruction associated with the fewest minutes to mastery, or most efficient pace, varied across participants. Skill maintenance also varied across participants. Results suggest that the optimal pace of instruction may vary across individuals. Implications for determining the optimal pace of instruction in discrete-trial training with young learners are discussed.
Notes on several phenomenological laws of quantum gravity

Phenomenological approaches to quantum gravity try to infer model-independent laws by analyzing thought experiments and combining both quantum, relativistic, and gravitational ingredients. We first review these ingredients -three basic inequalities- and discuss their relationships with the nature of fundamental constants. In particular, we argue for a covariant mass bound conjecture: in a spacetime free of horizon, the mass inside a surface $A$ cannot exceed $16 \pi G^2 m^2 m_p$ (5) There exists a mass dependent maximal force and power (6) There exists a maximal energy density and pressure (7) Physical systems must obey the Holographic Principle (8) Holographic bounds can only be saturated by systems with $m>m_p$; systems lying on the ``Compton line'' $l \sim 1/m$ are fundamental objects without substructures (9) We speculate on a new bound from above for the action. In passing, we note that the maximal acceleration is of the order of Milgrom's acceleration $a_0$ for ultra-light particles ($m\sim H_0)$ that could be associated to the Dark Energy fluid. This suggests designing toy-models in which modified gravity in galaxies is driven by the DE field, via the maximal acceleration principle.
INDOOR AIR STUDY OF FUNGI CONTAMINATION AT INTERNAL DEPARTMENTS FOR STUDENTS IN THI-QAR GOVERNORATE

Purpose : The purpose of the study was evaluation of the fungal presence in the environment of an internal departments for students. Materials and methods: The environment testing was carried out at a internal departments for students May 2014. The materials to mycological examinations were air samples (10 bedrooms) and swabs from two locations the kitchen (wall, floor, sink, cook, refrigerator, R.O-tank) and the bathroom (wall, floor, lavatory, washing machine). Samples were collected weekly. The findings were processed statistically. The t-test and Least significance difference to compared between the means were used. The border value of significance was 0.05. Results: The following fungal pathogens isolated from indoor environment of females internal department were Asperegillus flavus, A.niger, Candida albicans, Candida spp . , Rhodotorula spp . and Trichosporon spp. In contrast, colonies isolated from indoor environment of males internal department were Candida albicans, Candida spp . , Asperegillus niger, Aspergillus spp . and Trichosporon spp. In both departments Candida spp. were most frequently isolated from the indoor environment. A significant increase in the fungi isolated from the air and walls between departments was found. Conclusions: The main fungal pathogens isolated from the air samples were Candida spp. and Aspergillus spp. in the internal departments for students. Fungal occurrence in the air of rooms and walls varied between the both departments.
Construcciones alternativas del Puente Browniano

El proceso de Wiener-Lèvy constituye uno de los principales modelos en el Análisis Estocástico, debido a su sensiUez, así como a las múltiples propiedades que verifica: Es Gaussiano, tiene incrementos estacionarios independientes, es un proceso Markoviano de difusión, etc. Asimismo, se ha adoptado como modelo probabilístico de numerosos fenómenos naturales, siendo el más conocido el del movimiento browniano (Wiener, 1923: Einstein, 1956), Sin embargo, su simplicidad hace necesaria la introducción de otros modelos aleatorios más realistas y consiguientemente más complejos, tales como
Microwave confocal image for the localization of lung cancer

: Lung cancer is one of the most common causes of cancer-related death. Once detected it is usually removed through thoracoscopic surgery. However, during the surgery, since the lung deflates a new localization of the nodule is necessary. We suggest combining microwave imaging with a laparoscopic instrument to relocate the tumor during the surgery. In this contribution, a numerical analysis was undertaken to investigate the main parameters affecting microwave imaging such as frequency band, and depth of the nodule. It was found that at 600 MHz a nodule of 1 cm in radius could be imaged up to 10 cm of depth in the lung.
Agrobacterium -Mediated Genetic Transformation Involving Hygromycin Phosphotransferase to Impart Herbicide Tolerance in Indica Rice

: - Hygromycin phosphotransferase ( hpt) gene has been successfully intruded in an indica rice variety-IET 13856 through Agrobacterium -mediated genetic transformation to impart herbicide-tolerance. Transgenic plants were regenerated from in vitro developed embryogenic calli of IET 13856 through co-cultivation with Agrobacterium tumifaciens strain LBA 4404 (pTOK 233). The hpt gene was housed under the transcriptional control of CaMV 35S promoter and Nos polyadenylation signal in the super binary vector pTOK233. This protocol of Agrobacterium -mediated genetic transformation was found to be very efficient as evident from high (51.4% transient and 13.51% stable) transformation efficiency. Transient expression was confirmed through GUS histochemical assay, while stable transgene integration at the genomic level was confirmed by PCR, slot blot and Southern blot hybridization. Inheritance of the transgene was worked out through seed germination test of the seeds at T 1 generation on hygromycin supplemented MS medium. It showed typical Mendelian ratio for monogenic inheritance (dominant transgene) in the progenies of maximum transgenic lines except a few deviations, which might be due to epistatic interactions or small sample size (less number of seeds used in seed germination test). This study prospects amply, use of transgenic indica rice harbouring hpt to enhance productivity in rice by saving the crops from weed menace in Andaman and Nicobar Islands, India, endowed with prolonged high rain fall with rampant weed infestation and other rice growing areas elsewhere.
Prediction and Pan Code Reuse Attack by Code Randomization Mechanism and Data Corruption

: Policy-recycle attacks, such as return-oriented programming (ROP), are a group of buffer spread out attacks that repurpose existing executable code towards malevolent purpose. These attack bypass defenses against code vaccination attacks by chaining together sequence of instructions, commonly known as gadgets, to execute the beloved attack logic. A fine grained randomization based approach that break these assumptions by modifying the layout of the executable code and hinder code-reuse attack.Here we use data corruption advance for sending the data from sender to receiver without any attacks. Our clarification, Marlin, randomizes the internal structure of the executable code by randomly shuffling the function blocks in the aim binary. This denies the attacker with a priori knowledge of instruction addresses for constructing the desired develop payload. Our approach can be applied to any ELF binary and every execution of this binary uses a different randomization. Our work shows that such an approach incur low overhead and appreciably increases the level of safety against code-reclaim based attacks.
A Randomized Phase II Trial of Adjuvant Galinpepimut-S, WT-1 Analog Peptide Vaccine, after Multimodality Therapy for Patients with Malignant Pleural Mesothelioma

Purpose: Determine the 1-year progression-free survival (PFS) among patients with malignant pleural mesothelioma (MPM) receiving the WT1 peptide vaccine galinpepimut-S after multimodality therapy vs those receiving control adjuvants. Patients and Methods: This double-blind, controlled, two center phase II trial randomized MPM patients after surgery and another treatment modality to galinpepimut-S with GM-CSF and Montanide or GM-CSF and Montanide alone. An improvement in 1-year PFS from 50% to 70% was the predefined efficacy threshold, and 78 patients total were planned. The study was not powered for comparison between the two arms. Results: 41 patients were randomized. Treatment related adverse events were mild, self-limited, and not clinically significant. Based on a stringent prespecified futility analysis (futility = > 10 of 20 patients on one arm experiencing progression < 1 year), the control arm closed early. The treatment arm was subsequently closed because of the resultant unblinding. The PFS rate at 1 year from beginning study treatment was 33% and 45% in the control and vaccine arms, respectively. Median PFS was 7.4 months vs 10.1 months and median OS was 18.3 months vs 22.8 months in the control and vaccine arms, respectively. Conclusion: The favorable safety profile was confirmed. PFS and OS were greater in those who received vaccine but the trial was neither designed nor powered for comparison between the arms. Based on these promising results, the investigators are planning a larger randomized trial with greater statistical power to define the optimal use and benefit of galinpepimut-S in the treatment of MPM. The development of novel therapeutic strategies in malignant pleural mesothelioma (MPM) is dependent on exploiting its molecular aberrations. The high expression of WT-1 in most MPM and its absence in normal adult tissues make it a promising target for new treatments and, in particular, for a tumor selective vaccine. Here, we report the results of a randomized phase II evaluating a multivalent WT-1 peptide vaccine, galinpepimut-S, in the treatment of MPM after multimodality therapy. In addition to demonstrating a signal for efficacy, we show that the vaccine stimulates immune responses in certain individuals and an immune response was associated with improved survival, although this did not reach statistical significance. Based on these promising results, a large randomized phase III trial is planned for patients with WT-1 expressing mesothelioma.
Improving Voluntary, Rights-Based Family Planning: Experience From Nigeria And Uganda

Background: Growing focus on the need for voluntary, rights-based family planning (VRBFP) has drawn attention to the lack of programs that adhere to the range of rights principles. This paper describes two ﬁ rst-of-their-kind interventions in Kaduna State, Nigeria and in Uganda in 2016 – 2017, accompanied by implementation research based on a conceptual framework that translates internationally agreed rights into family planning programming. Methods: This paper describes the interventions, and pro ﬁ les lessons learned about VRBFP implementation from both countries, as well as measured outcomes of VRBFP programming from Nigeria. Results: The intervention components in both projects were similar. Both programs built provider and supervisor capacity in VRBFP using comparable curricula; developed facility-level action plans and supported action plan implementation; aimed to increase clients ’ rights literacy at the facility using posters and handouts; and established or strengthened health committee structures to support VRBFP. Through the interventions, rights literacy increased, and providers were able to see the bene ﬁ ts of taking a VRBFP approach to serving clients. The importance of ensuring a client focus and supporting clients to make their own family planning choices was reinforced. Providers recognized the importance of treating all clients, regardless of age or marital status, for example, with dignity. Privacy and con ﬁ dentiality were enhanced. Recognition of what violations of rights are and the need to report and address them through strong accountability systems grew. Many lessons were shared across the two countries, including the need for rights literacy; attention to health systems issues; strong and supportive supervision; and the importance of working at multiple levels. Additionally, some unique lessons emanated from each country experience. Conclusion: The assessed feasibility and bene ﬁ ts of using VRBFP programming and outcome measures in both countries bode well for adoption of this approach in other geographies. provider-client clinical observations – mind- and behavior-shift.
WATERSHED MANAGEMENT BETTAHALASURU USING GIS AND REMOTE SENSING

: Satellite remote sensing data with geographic information system has a pragmatic approach to map and generate spatial input layers of predicting response behavior and yield of watershed. Hence, in the present study an attempt has been made to understand the hydrological process of the command area at the watershed level by drawing the inferences from soil loss estimation. The study area chosen for the present study is Bettahalasuru command area situated in Bengaluru North lies geographically between 13°10'8"N and 13°9'12"N latitude and 77°35'58"E and 77°37'35"E longitude and toposheet No:57 G/12. It covers an area of 3.8 Sqkm and perimeter of 7.89km. Top few centimeters of the soil will usually be fertile, which is very important for the agricultural practices. Soil loss estimation was carried out in order to assess the erosion rate. If the erosion rate is severe, immediate steps should be undertaken to conserve the soil. Several methods were suggested in the past but due to its robustness, USLE (Universal Soil Loss Estimation) model has been adopted in the present study. The weighted soil erosion estimated was 16.53 t/ha/year which is Moderate soil loss. Hence should adopt conservation practices to reduce soil loss.
University of Birmingham Modifying the maker : oxygenases target ribosome biology

The complexity of the eukaryotic protein synthesis machinery is partly driven by extensive and diverse modi ﬁ cations to associated proteins and RNAs. These modi ﬁ cations can have important roles in regulating translation factor activity and ribosome biogenesis and function. Further investigation of ‘ translational modi ﬁ cations ’ is warranted considering the growing evidence implicating protein synthesis as a critical point of gene expression control that is commonly deregulated in disease. New evidence suggests that translation is a major new target for oxidative modi ﬁ cations, speci ﬁ cally hydroxylations and demethylations, which generally are catalyzed by a family of emerging oxygenase enzymes that act at the interface of nutrient availability and metabolism. This review summarizes what is currently known about the role or these enzymes in targeting rRNA synthesis, protein translation and associated cellular processes. as a 2OG competitive inhibitor in others. Succinate and fumarate inhibit 2OG-oxygenases by product inhibition and 2OG competition, respectively.