Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comparitive Study of KNN and EvABCD Classification Method for Customer Behavior

: -commerce is the new business techniques which deal with the various needs of organizations, retailer and consumers to reduce cost by developing the goods quality and services which also increase the delivery speed with the help of Internet. This is different from the established electronic commerce by enabling the goods trading, money and electronically information from computer to computer. Information about the users in computers is helpful in forecasting the future behaviors of the computer user. An Evolving Agent Behavior Classification based on Distributions (EvABCD) method mainly depends on the customer’s observed behavior. This will modify the user’s interest in search specified in the user profiles automatically when the user interest in search changes and will retrieve the search results on internet. This new method is very efficient in adapting the evolving user profiles and provides the better search results based on the user’s interest.
STUDY OF CLINICAL PROFILE, RISK FACTORS AND OUTCOME OF SEPSIS IN ELDERLY

Introduction: Sepsis is the most common cause for hospitalization in the ICU around the world. The clinical presentation of older patients with sepsis is often atypical, leading to a difficult and delayed diagnosis. Prompt diagnosis is crucial to the management of sepsis, as initiation of early-goal-directed therapy is the key to reducing mortality from severe sepsis in older patients. Unless antibiotics and life support are delivered quickly, the can lead to organ failure and death. Objectives: To study the risk factors and clinical profile of sepsis in elderly. To record the primary site of infection and to determine the influence of sepsis on the survival outcome in the elderly. Materials and methods: A hospital based observational study was conducted on patients admitted to to Sri 100 Patients ≥ 65 years of age admitted with a clinical suspicion of sepsis and those fulfilling the criteria for sepsis by PIRO grading system who gives informed consent for the study. Patients are to be divided into groups based on their age. All patients’ clinical presentation, previous medical history and outcomes as death/discharge and duration of hospital stay are to be recorded and analysed according to the age groups. Results: 100 subject studied, 64 were males and commonly seen in the age group 65 – 74yrs. Mean hospital stay in pts was 5.1 days with SD 5.2 days. risk Most common Nine percent patients 42% 45% 2 foci 4% 3 foci 54.7% of Males 2 females time between Respiratory site, UTI and 23 subjects 73.9% 25% 23% Conclusion: Sepsis is more commonly males Elderly patients can develop sepsis even without fever seen 29% of this study. Respiratory system was found to be the most common site of infection. A significant number of patients developed complications in the form of ICU admission, Ventilator support, acute renal failure and septic shock. There was significant association between Respiratory foci and complications such as Shock and ICU admission and a significant association between ARF and Cellulitis was also seen.
Rapid and Speciﬁc Method for Evaluating Streptomyces Competitive Dynamics in Complex Soil Communities (cid:1) †

Quantifying target microbial populations in complex communities remains a barrier to studying species interactions in soil environments. Quantitative PCR (qPCR) assays were developed for quantifying pathogenic Streptomyces scabiei and antibiotic-producing Streptomyces lavendulae strains in complex soil communities. This assay will be useful for evaluating the competitive dynamics of streptomycetes in soil. a communities. Streptomyces strains DL93 ( Streptomyces lavendulae , an antibiotic producer that is effective in plant disease biocontrol [9]) and DL87 ( Streptomyces scabiei , a plant patho-gen) were studied in the present work. This approach has signiﬁcant potential to shed light on the diversity and complex-ity of Streptomyces species interactions in soil.
PENANGANAN PENDERITA APNEA TIDUR DAN KEBIASAAN MENDENGKUR (MANAGEMENT OF SLEEP APNEA SYNDROME AND SNORING HABIT)

Sleep apnea syndrome (SAS), a common disorder, is characterized by repetitive episodes of cessation of breathing during sleep, resulting in hypoxemia and sleep disruption. The consequences of the abnormal breathing during sleep include daytime sleepiness, neurocognitive dysfunction, development of cardiovascular disorders, metabolic dysfunction, and impaired quality of life. There are three types of SA: obstructive sleep apnea (OSA), central sleep apnea (CSA) and mixed sleep apnea (MSA). OSA is a prevalent disorder in which there are snoring, repetitive apneic episodes, and daytime sleepiness. The diagnosis of SA includes assessment of subjective symptoms and apneic episodes during sleep documented by polysomnography. Treatments of OSA include continuous positive airway pressure (CPAP), oral appliance, and surgery; patients with CSAS are treated with oxygen, adaptive servo-ventilation, or CPAP. With assessment and treatment of the SA, patients usually have resolution of their disabling symptoms, subsequently resulting in improved quality of life. As conclusion, the succesful treatment depends on the choice of treatment either surgery or non surgery by patient. Early examination and risk that maybe occure is very important to inform before treatment is performed.
Analysis of the (cid:2) E Regulon in Crohn’s Disease-Associated Escherichia coli Revealed Involvement of the waaWVL Operon in Bioﬁlm Formation

Ileal lesions of patients with Crohn’s disease are colonized by adherent-invasive Escherichia coli (AIEC), which is able to adhere to and to invade intestinal epithelial cells (IEC), to replicate within macrophages, and to form bioﬁlms on the surface of the intestinal mucosa. Previous analyses indicated the involvement of the (cid:2) E pathway in AIEC-IEC interaction, as well as in bioﬁlm formation, with (cid:2) E pathway inhibition leading to an impaired ability of AIEC to colonize the intestinal mucosa and to form bioﬁlms. The aim of this study was to characterize the (cid:2) E regulon of AIEC strain LF82 in order to identify members involved in AIEC phenotypes. Using comparative in silico analysis of the (cid:2) E regulon, we identiﬁed the waaWVL operon as a new member of the (cid:2) E regulon in reference AIEC strain LF82. We determined that the waaWVL operon is involved in AIEC lipopolysaccharide structure and composition, and the waaWVL
Energy release rate in hydraulic fracture

A novel hydraulic fracture (HF) formulation is introduced which accounts for the hydraulically induced shear stress at the crack faces. It utilizes a general form of the elasticity operator alongside a revised fracture propagation condition based on the critical value of the energy release rate. It is shown that the revised formulation describes the underlying physics of HF in a more accurate way and is in agreement with the asymptotic behaviour of the linear elastic fracture mechanics. A number of numerical simulations by means of the universal HF algorithm previously developed in Wrobel & Mishuris (2015) are performed in order to: i) compare the modiﬁed HF formulation with its classic counterpart and ii) investigate the peculiarities of the former. Computational advantages of the revised HF model are demonstrated. Asymptotic estimations of the main solution elements are provided for the cases of small and large toughness. The modiﬁed formulation opens new ways to analyse the physical phenomenon of HF and also improves the reliability and eﬃciency of its numerical simulations.
Mice /lpr of Lupus-like Symptoms in MRL Onset Collagen-Induced Arthritis and Earlier Siglec-G Deficiency Leads to More Severe

Siglec-G is a member of the sialic acid–binding Ig-like lectin (Siglec) family expressed on all B cells. Siglec-G–deﬁcient mice show a large expansion of the B1 cell compartment, demonstrating the crucial role of Siglec-G as an inhibitory receptor on this cellular subset. Although Siglec-G–deﬁcient mice did not develop spontaneous autoimmunity, mice double-deﬁcient for Siglec-G and the related Siglec protein CD22 did show autoimmunity at an older age. In this study, we addressed the question of whether loss of Siglec G on its own affects disease severity in animal models of rheumatoid arthritis and systemic lupus erythematosus. Siglec-G– deﬁcient mice showed moderately increased clinical severity and higher inﬂammation of the knee joints following collagen-induced arthritis, when compared with control mice. The Siglec-G–deﬁcient mouse was also backcrossed to the autoimmune prone MLR /lpr background. Although both Siglec-G–deﬁcient and control MRL /lpr mice developed a lupus-like disease, Siglec-G–deﬁcient MRL /lpr mice showed an earlier occurrence of autoantibodies; a higher lymphoproliferation of B and T cells; and an earlier onset of disease, as shown by proteinuria and glomerular damage in the kidney. Moreover, Siglec-G–deﬁcient female mice showed a signiﬁcantly reduced survival compared with female control MRL /lpr mice. Thus, the loss of the inhibitory receptor Siglec-G led to a moderate exacerbation of disease severity and early onset in
From Unsupervised Multi-Instance Learning to Identiﬁcation of Near-Native Protein Structures

A major challenge in computational biology regards recognizing one or more biologically-active/native tertiary protein structures among thousands of physically-realistic structures generated via template-free protein structure prediction algorithms. Clustering structures based on structural similarity remains a popular approach. However, clustering organizes structures into groups and does not directly provide a mechanism to select individual structures for prediction. In this paper, we provide a few algorithms for this selection problem. We approach the problem under unsupervised multi-instance learning and address it in three stages, ﬁrst organizing structures into bags, identifying relevant bags, and then drawing individual structures/instances from these bags. We present both non-parametric and parametric algorithms for drawing individual instances. In the latter, parameters are trained over training data and evaluated over testing data via rigorous metrics.
ROBUST FACE-NAME GRAPH MATCHING FOR DIFFERENT MOVIE FRAMES

: Auto face identification of characters in films has drawn most research interests and led to many interesting applications. Since huge variation in the appearance of each character is found, it is a challenging problem. Existing methods evaluate promising results in clean environment, the performances are limited in complex movie scenes due to the noises generated during the face tracking and face clustering process. This study presents two scheme of global face-name matching based frame work for robust character identification. This contribution of this study include: 1) A noise insensitive character relationship representation is incorporated.2) The study introduces an edit operation based graph matching algorithm.3) Complex character changes are handled by simultaneously graph partition and graph matching. algorithm4) Beyond existing character identification approaches, we further perform an in-depth sensitivity analysis by introducing two types of simulated noises. The proposed schemes demonstrate state-of-the-art performance on movie character identification in various movies .
STATISTICAL OPTIMIZATION OF HERBAL CREAM CONTAINING WOUND HEALING AND ANTIFUNGAL AGENTS

Different fungi are always present on surface of the skin. Infection occurs when these organisms enter into body. Fungal infection is a very common ailment of day to day life. Wound refers to a sharp injury which damages the dermis of skin. Microbes i.e. bacteria or fungi are found on wounds. Alkaline wound fluid will promote growth of both bacteria and fungi. The aim of the research is to formulate a cream which treats fungal infection as well as heal wounds which occur due to intense scratching and itching. Conventional therapy shows varied side effects and thus it is need of hour to find an alternative therapy. Herbal therapy is the best option here. Thus, the present study focuses on preparation of methanolic extract and herbal oil and formulating it in a patient friendly formulation i.e. Cream. The cream was formulated and optimized by using 3 2 factorial design with concentration of stearic acid and tween 80: span 20 as factors and viscosity, spreadability and drug release as responses. The cream with 4% tween 80: span 20 and 2 gram stearic acid was considered as optimized. The optimized cream showed maximum drug release through drug (karanj oil) present in oil phase and cream was found to give good results.
Grundbruchversagen bei geogitterbewehrten Stützkonstruktionen

Die Bemessung von Stützbauwerken beinhaltet nach EC 7 und DIN 1054 den Nachweis der Grundbruchsicherheit in Anlehnung an DIN 4017. Der für starre Fundamente entwickelte Ansatz zur Ermittlung des Grundbruchwiderstands wurde auf geogitterbewehrte Stützkonstruktionen übertragen. Vorgaben für die Nachweisführung finden sich in der EBGEO und anderen internationalen Regelwerken. Aufgrund der unterschiedlichen Eigenschaften flexibler und starrer Konstruktionen wird das tatsächliche Grundbruchversagen von geogitterbewehrten Stützkonstruktionen in physikalischen Modellversuchen am Lehrstuhl für Geotechnik im Bauwesen der RWTH Aachen untersucht.
A CASE/CONTROL STUDY ON RAISED ANTI-THYROID PEROXIDASE ANTIBODY IN CASES OF HYPOTHYROIDISM AND EUTHYROIDS

: Objective: To assess the raised level of anti-thyroid peroxidase antibody in patients of hypothyroidism and euthyroids. Material and methods: This case/control study was conducted at Department of pathology, BUMHS Quetta from January 2018 to June 2018 over the period of 6 months. Total 69 patients of hypothyroidism (as per operational definition) having age 18-60 years either male or female were selected. Age and sex matched euthyroids (FT3, FT4 and TSH within normal range) as described in operational definition was served as controls. Anti-thyroid peroxidase antibody assessed between the cases of controls. Results: A total of 138 cases fulfilling the inclusion/exclusion criteria were enrolled to compare the frequency of raised level of anti-thyroid peroxidase antibody in patients of hypothyroidism and euthyroids. Comparison of raised anti-thyroid peroxidase antibodies in both groups was done which reveals that Raised Anti-Thyroid Peroxidase Antibodies were recorded in 28.99%(n=20) in Group-A and 7.25%(n=5) in Group-B while 71.01%(n=49) in Group-A and 92.75%(n=64) in Group-B had no findings of Raised Anti-thyroid Peroxidase Antibodies, p value was calculated as 0.000 which shows a significant difference between the two groups. Conclusion: We concluded positive relationship of the presence of TPOAbs with levels of TSH and showed that TPOAbs and TSH predict future development of hypothyroidism. These results are consistent with the presence of TPOAbs necessitating a compensatory increase in levels of TSH for maintenance of euthyroidism, even in the euthyroid range.
Bambeiha Stephen Asiimwe Epidemiology and Translational Science DOCTOR OF PHILOSOPHY Interventions to mitigate the impact of HIV infection in key populations in sub-Saharan Africa DISSERTATION

In sub-Saharan Africa (SSA), the region with the world’s highest HIV prevalence, antiretroviral therapy (ART) has recently reduced AIDS-related deaths. However, death rates still remain unacceptably high, as do the numbers of new HIV infections. HIV treatment is also often provided by stand-alone HIV clinics, distinct from other healthcare services. As the people living with HIV (PLWH) start to survive into older age, adequately addressing emerging challenges, including but not limited to age-related diseases and disabilities, will require more integration for HIVand non-HIV services. Whereas ART, especially early ART for all HIV-infected patients, is the single most important intervention against HIV-related mortality and morbidity, the persistence of some complications (e.g., HIV-associated neurocognitive disorder [HAND]) and high rates of residual mortality in the ART era suggest that additional interventions are needed. In the first chapter of my dissertation, I present a comparison of the cognitive scores of PLWH in a rural community in South Africa and HIV-negative comparators in the same community. Although adverse cognitive outcomes have been reported in clinical studies PLWH, no prior population-based studies in SSA have compared cognitive functioning among PLWH and HIV-negative comparators. The baseline data of participants in the “Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa” (HAALSI), a population-based cohort in rural Agincourt, Mpumalanga, northeast South Africa, were analyzed. Participants, who are men and women aged at least 40 years. Cognitive scores on a conventional instrument assessing orientation, immediate and delayed recall, and numeracy for 4,560 participants, and a novel instrument (the Oxford Cognitive Screen [OCS]-Plus), assessing memory, language, visual-spatial ability, and executive functioning for 1,997 participants were used to measure cognitive functioning. We used linear regression to compare composite cognitive scores between PLWH and HIV-negative participants, and among PLWH, anti-retroviral therapy (ART) users
Survivin is highly expressed in CD34 (cid:1) 38 (cid:2) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML

Survivin, a member of the inhibitors of apoptosis protein family, plays important roles in cell proliferation and survival and is highly expressed in various malignan-cies,includingleukemias.Tobetterunder- stand its role in acute myeloid leukemia (AML), we proﬁled survivin expression in samples obtained from 511 newly diagnosed AML patients and in CD34 (cid:1) 38 (cid:2) AML stem/progenitor cells using a validated reverse-phase protein array; we correlated its levels with clinical outcomes and with levels of other proteins in the same sample set. We found that survivin levels were higher in bone marrow than in paired peripheral blood leukemic cells (n (cid:3) 140, P (cid:3) . 0001) and that higher survivin levels signiﬁcantly predicted shorter overall ( P (cid:3) . 016) and event-free ( P (cid:3) . 023) survival in multivariate Cox model analysis. Importantly, survivin levels were signiﬁcantly higher in CD34 (cid:1) 38 (cid:2) AML stem/progenitor cells than in bulk blastsandtotalCD34 (cid:1) AMLcells( P < .05). Survivin expression correlated with the expressions of multiple proteins involved with cell proliferation and survival. Particularly, its expression strongly correlated with HIF1 (cid:4) in the stem/progenitor cell compartment. These results suggest that survivin is a prognostic biomarker in AML and that survivin, which is overexpressed in AML stem/progenitor cells, remains a potentially important target for leukemia therapy. ( Blood . 2012;120(1): 173-180) and any of the following
Determinants of patients' needs in asthma treatment

Patients ’ needs in asthma remain insuf ﬁ ciently understood and met. We therefore aimed to investigate the potential determinants of patients ’ needs in asthma treatment. Our study was based on survey data on 189 adults with asthma. Needs were measured using the 13-item Needs in Asthma Treatment questionnaire, which yields a total score and subscale-speci ﬁ c scores ( ‘ exacerbations ’ , ‘ patient expertise ’ , ‘ handling drugs ’ and ‘ drug effects ’ ). We considered age, sex, education, years since diagnosis and anxiety/depression (measured by the Patient Health Questionnaire-4) as potential determinants. Associations were estimated by multivariable linear regression. Overall, we observed that younger age, poor mental health and a more recently established asthma diagnosis were independently associated with increased needs. Information on drug effects was an exception to this pattern as the need in that domain was solely determined by sex (being greater in men). In conclusion, our study provides novel evidence on patient characteristics that are associated with needs in asthma treatment. If con ﬁ rmed by future studies, our observations may assist healthcare professionals to identify asthma patients with potentially elevated information, support and training needs and could contribute to the development of tailored interventions. the current responses versus 0=no and mean c and a total score. potential score range on each subscale and the total may vary from 0.0 to 1.0, higher scores higher need. The NEAT subscales and the total good internal consistency, increasing levels of unmet needs outcomes and research. interpretation data: authors; preparation of manuscript
PGJ 2 -stimulated (cid:1) -cell apoptosis is associated with prolonged UPR activation

2 -stimulated (cid:1) -cell apoptosis is associated with prolonged UPR activation. prolif-erator-activated receptor- (cid:2) (PPAR (cid:2) ) ligands have been shown to possess anti-inﬂammatory properties that include the inhibition of transcription factor activation and the expression of inﬂammatory genes. Using pancreatic (cid:1) -cells, we have shown that PPAR (cid:2) ligands such as 15-deoxy- (cid:3) 12,14 -prostaglandin J 2 (PGJ 2 ) attenuate interferon- (cid:2) induced signal transducer and activator of transcription 1 activation and interleukin (IL)-1 (cid:1) -induced nuclear factor- (cid:4) B activation by a pathway that correlates with endoplasmic reticulum stress and the induction of the unfolded protein response (UPR). The UPR is a conserved cellular response activated by a number of cell stressors and is believed to alleviate the stress and promote cell survival. However, prolonged activation of the UPR results in cellular death by apoptosis. In this report, we have examined the effects of PGJ 2 on UPR activation and the consequences of this activation on cell survival. Consistent with induction of a cell death pathway, treatment of rat islets and RINm5F cells for 24 h with PGJ 2 results in caspase-3 activation and caspase-dependent (cid:1) -cell death. The actions of these ligands do not appear to be selective for (cid:1) -cells, because PGJ 2 stimulates macrophage apoptosis in a similar fashion. Associated with cell death is the enhanced phosphorylation of eukaryotic initiation factor 2 (cid:5) (eIF2 (cid:5) ), and in cells expressing a mutant of eIF2 (cid:5) that cannot be phosphorylated, the stimulatory actions of PGJ 2 on caspase-3 activation are augmented. These ﬁndings suggest that, whereas PGJ 2 -induced UPR activation is associated with an inhibition of cytokine signaling, prolonged UPR activation results in cell death, and that eIF2 (cid:5) phosphorylation may function in a protective manner to attenuate cell death. RPMI before initiation of experiments. Using this method, we routinely obtain a transfection efﬁciency of (cid:9) 50% as determined by EGFP expression. Statistics. Statistical comparisons were made between groups using one-way ANOVA. Signiﬁcant differences between groups, treated compared with unstimulated controls ( P (cid:10) 0.05), were determined by Newman-Keuls post hoc analysis.