Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of ingestion of red dragon fruit extract on levels of malondialdehyde and superoxide dismutase after strenuous exercise in rats ( Rattus norvegicus)

Background: Prolonged activation of skeletal muscles causes a decrease in the production of fatigue. Exercise with strenuous intensity causes an increase in Reactive Oxygen Species (ROS). An increase in free radicals causes oxidative stress resulting in damage to cell function to mitochondrial dysfunction, and fatigue. This study aimed to determine the antioxidant potential of red dragon fruit (RDF) to delay fatigue due to oxidative stress, which improves cell function in mitochondria. Methods: 25 male rats ( Rattus norvegicus) aged three months were divided into five groups: Group K1 was N.A. (No Activity) but drinking and eating; Group K2 performed strenuous exercise without RDF treatment; Groups 3, 4, and 5 (P1, P2 and P3, respectively) performed strenuous exercise and were treated with 75 mg kg -1.bw, 150 mg kg -1.bw, and 300 mg kg -1.bw of RDF extract, respectively. The exercise for the rats involved intense swimming for 20 minutes a day three time a week for fouweeks. Malondialdehyde (MDA) dan SOD was measured with the ELISA and histopathology for muscle soleus and lung tissue. Results: Strenuous exercise followed by RDF extract ingestion was compared for fatigue in terms of duration and time; before (24.55±1.38 minute) and after (95.31±7.82 minute) and led to a significant difference of 39% (p<0.01). The study also compared MDA before and after RDF extract ingestion in the K2 vs. the P1 group (p<0.05). At the same time, P2 differed more significantly (p<0.01). This indicated a spread of free radicals and featured histopathological damage of muscle cells. However, ingestion of RDF extract leads to improvement of soleus muscle cells; thus, repairs cell function, delaying fatigue. Conclusion: This study confirmed that strenuous exercise, which causes an increase in ROS, intensifies free radicals with RDF extract ingestion and declines oxidative stress, repairing cell function and delaying fatigue.
Drug interactions between herbal medicines and oral contraceptives

The use of herbal medicines has grown considerably in recent years, due to the erroneous thought that products of plant origin are harmless, and therefore do not cause adverse effects or have drug interactions. The use of these drugs with oral contraceptives can bring risks to patients. The potential negative clinical effects that can be caused by these drug interactions must be emphasized to prevent risks and ensure the effectiveness of this contraceptive method that is one of the most used by women seeking to prevent pregnancy. The users of herbal medicines usually believe that herbal medicine is a therapeutic alternative free of adverse effects and/or incapable of causing drug interactions, but herbal medicines are composed of several chemical compounds, which, in turn, may be responsible for antagonistic and/or synergistic effects with other drugs. The main interactions that can occur with contraceptives are with popularly used herbal medicines such as licorice, alfalfa, cannabis, cimicifuga, St. John's wort, ginseng, kava-kava, saw palmetto, sene, and soy. The herbal medicines have several chemical compounds, among which we highlight the secondary metabolites, responsible for the pharmacological actions and mechanism of action of drug interactions, which are often similar in plants that have in their composition the same metabolites, as in the case of saponins and isoflavones that reduce the speed of biotransformation of oral contraceptives.
Mathematical Modeling of the Film Influence on the Salting Time of Mozzarella Cheese in a Static and Dynamic System: Application of Artificial Neural Networks of the Multilayer Perceptron Type

The NaCl and KCl diffusion in the film formed on the cheese surface during salting was simulated by the finite element method. The time and salts concentration values on the cheese surface were determined, tabulated, and presented to the multilayer perceptron neural network (MLP) for the regression modeling. The samples were divided into 70, 15 and 15% for training, testing, and validation, respectively. The networks with the best performance showed 5 to 12 hidden layers. The Tukey’s test showed that there was no significant difference, at the 5% level, between the time value used and the mean value modeled for training, testing, and validation for the NaCl. For the KCl, a significant difference was observed only for 2 training samples and 1 test sample. Sensitivity analysis showed that the discrete variable Z, which represents the static and dynamic systems, was the most important in the models’ construction.
Effect of Different Types of Mulching on Soil Properties and Tree Growth of Magnolia champaca Planted at the Montane Rainforest in Cameron Highlands, Pahang, Malaysia

Tropical Montane Cloud Forest (TMCF) is among the most vulnerable habitats to fragmentation, deforestation, and global climate change. A successful restoration program requires a comprehensive understanding of variables influencing seedling efficiency. This study was conducted on Sg. Terla Forest Reserve Cameron Highlands, Pahang, Malaysia. In this study, we used a randomized complete block design (RCBD) and measured the Magnolia champaca height, root collar diameter, diameter at breast height, plant survival, root diameter, main root length, lateral root length, root coiling, root direction, and chlorophyll content. The soil samples were taken to study the effect of different mulching materials on soil characteristics. We also measured soil compaction, soil texture, soil colour, soil moisture content, soil organic carbon, total nitrogen, total sulphur, available phosphorus, and exchanged potassium. This study indicates that mulching had no significant effect on plant height, diameter breast height, root collar diameter, and chlorophyll content between treatments. Although mulching had a significant effect on root diameter, main root length, and root distributions among treatments while for lateral root length and root:shoot ratio did not show a significant effect among treatments. However, oil palm mulching treatment had a greater effect on plant height, root collar diameter, and diameter at breast height growth, among treatments. Mulching significantly affected soil pH, soil moisture content, total sulphur, and potassium exchange. In contrast, mulching did not significantly affect soil organic carbon, total soil nitrogen, and soil available phosphorus between treatments.
INFLUENCE OF FINANCIAL CAPABILITIES ON COMPETITIVENESS OF FOOD AND BEVERAGE MANUFACTURING FIRMS IN KENYA

Purpose: The firms have been facing steep competition from foreign companies due to increased globalization. The aim of the study was to find out the influence of financial capabilities on competitiveness of food and beverage processing companies in Kenya. Methodology: The study was informed by resource based theory. Empirical studies were reviewed to provide the basis for research gaps to be filled by the current study. Descriptive research design was employed while the target population was the 187 food and beverage processing firms in Kenya. A census was used where all the 187 companies were contacted. Structured questionnaire was used to obtain the primary data which was analyzed through mixed method analysis. Descriptive statistics were used to analyze quantitative data while qualitative data was analyzed through content analysis. Inferential statistics were used to analyze the relationship between variables through the regression model. The findings were presented in form of tables, pie-charts and bar-graphs. Results: The companies however mainly relied on bank deposits as the source of funding for their operations. Financial capabilities significantly and positively influence the competitiveness of the food and beverage processing firms. The bank deposits, cash holdings and stock holdings create the financial muscle of the firms by ensuring that they are able to obtain adequate and high quality production inputs thus contributing to the companies’ success. The correlation analysis revealed that there was a positive and significant association between Financial capabilities and firm competitiveness (r = 0.698, p = 0.000). Regression of coefficients results revealed that Financial capabilities and firm competitiveness are positively and significantly related (β =0.638, p=0.000). Unique contribution to theory, practice and policy: The firms ought to seek adequate financial capabilities as a way of effectively financing their operations to gain competitiveness. The companies should embrace accountability and proper investments that increase their bank deposits, cash holdings and stock holdings through which they can sustain their operations towards competitiveness. The companies should embrace accountability and proper investments that increase their bank deposits, cash holdings and stock holdings through which they can sustain their operations towards competitiveness.
Physical Training as a Blood Pressure Reducer and a Remodeler of Cardiac Fibers in Spontaneously Hypertensive Rats (SHR)

Background: Hypertension is the most prevalent of all cardiovascular diseases, reaching target organs such as the heart. Blood pressure control is critical for preventing organ damage induced by hypertension. Objective: To analyze blood pressure, heart rate, left ventricular thickness, the percentage of cardiac fibrosis and the percentage of type III collagen in Spontaneously Hypertensive Rats (SHR) submitted to swimming physical training. Methods: The experimental groups were composed of male Wistar Kyoto (WKY) rats (309-311g), which were divided into: 1) Normotensive Sedentary group (SN) (n = 6); 2) Trained Normotensive group (TN) (n = 6); 3) Sedentary Hypertensive group (SH) (n = 6); 4) Trained Hypertensive group (TH) (n = 6). After the end of the protocol, the animals were initially anesthetized to measure blood pressure. Results: Physical training was responsible for decreasing blood pressure (F = 16,968; p <0.001) and heart rate (F = 10.710; p = 0.004) in the trained groups (normotensive and hypertensive). Moreover, training was responsible for providing an increase in the thickness of the left ventricle (F = 7,254; p = 0.014) and a reduction in the percentage of cardiac fibrosis (F = 16,081; p <0.001). Furthermore, it was observed that the trained group had lower values of type III collagen (F = 13,166; p = 0.002). Conclusions: Physical swimming training triggered a decrease in blood pressure, heart rate, the percentage of fibrosis and the percentage of type III collagen. In addition, there was also a cardiac remodeling due to the increase in left ventricular hypertrophy.
Exploration of Unsteady Squeezing Flow through Least Squares Homotopy Perturbation Method

Squeezing flow has many applications in different fields including chemical, mechanical, and electrical engineering as these flows can be observed in many hydrodynamical tools and machines. Due to importance of squeezing flow, in this paper, an unsteady squeezing flow of a viscous magnetohydrodynamic (MHD) fluid which is passing through porous medium has been modeled and analyzed with and without slip effects at the boundaries. The least squares homotopy perturbation method (LSHPM) has been proposed to determine the solutions of nonlinear boundary value problems. To check the validity and convergence of the proposed scheme (LSHPM), the modeled problems are also solved with the Fehlberg–Runge–Kutta method (RKF45) and homotopy perturbation method (HPM) and residual errors are compared with LSHPM. To the best of the authors’ knowledge, the current problems have not been attempted before with LSHPM. Moreover, the impact of different fluid parameters on the velocity profile has been examined graphically in slip and no-slip cases. Analysis shows that the Reynolds number, MHD parameter, and porosity parameter have opposite effects in case of slip and no slip at the boundaries. It is also observed that nonzero slip parameter accelerates the velocity profile near the boundaries. Analysis also reveals that LSHPM provides better results in terms of accuracy as compared to HPM and RKF45 and can be effectively used for the fluid flow problems.
Hosting Major International Sports Events in a Country: A Socioeconomic Impact

This research focuses on the impact of sponsoring major sports events concerned with the socioeconomic aspects of Qatar. Context is the hosting of FIFA 2022 in Qatar. A questionnaire has been developed based on the underpinning theory, which included seven dimensions of measuring socioeconomic impact that covered Micro, Meso, Macroeconomic, Employment, Quality of Life, Social Cohesion and Environmental aspects. Questionnaire survey was conducted for a sample size of 126, which included the managers from tourism industry and sponsoring of sports events. The research methodology involved descriptive statistics calculations using MS Excel and SPSS. The response score was collected on a 5-point Likert scale for quantitative measures and the Mean, Standard Deviation, Kurtosis, Skewness and Frequency Distributions were computed for seven dimensions. The responses were later categorized into degrees of agreement with a priori scale to understand the relative impact of sponsoring sports events concerned with socioeconomic aspects. The results have indicated that, the highest impact would be on the creation of Environmental Consciousness among the citizens of Qatar followed by the impact on the Micro, Meso and Macroeconomic aspects of the country. These revelations have led providing suggestions to policy makers, which would be useful particularly in the present situation where Qatar is planning for FIFA 2022.
OPTH_A_328160 3787..3795

1Department of Vitreoretinal Services, Disha Eye Hospitals, Kolkata, West Bengal, India; 2Department of Vitreoretinal Services, Netralayam Super Speciality Eye Care Centre, Kolkata, West Bengal, India; 3Department of Vitreoretinal Services, Surya Eye Institute and Research Center, Mumbai, Maharashtra, India Purpose: To assess the short-term efficacy and safety profile of intravitreal brolucizumab injection in Indian eyes with neovascular age-related macular degeneration (nAMD) under real-world conditions. Patients and Methods: This was a multicenter, retrospective chart review of 94 eyes of 94 patients with nAMD (treatment-naïve and switch-therapy) undergoing brolucizumab therapy. Re-treatment as per pro-re-nata protocol was performed based on fixed visual and tomographic criteria. The main outcome measures were changes in the best-corrected visual acuity (BCVA), intraretinal fluid (IRF), subretinal fluid (SRF), central subfield thickness (CST), and pigment epithelial detachment (PED) along with safety analysis. Results: Of the 94 eyes, 20 eyes (21.3%) were treatment-naïve, whereas the rest 74 eyes (78.7%) underwent switch therapy. One hundred and twenty-six injections were given over a mean followup of 7.3 ± 2.2 (range 5–30) weeks. The BCVA improved significantly from 0.82 ± 0.5 LogMAR at baseline to 0.66 ± 0.5 LogMAR at the final visit (p < 0.0001). Significant reduction in CST was simultaneously noted (Baseline: 408.45 ± 65.63 μm; Final: 281.14 ± 37.74 μm; p < 0.0001). On qualitative analysis, resolution of subretinal fluid (SRF), intraretinal fluid (IRF), and pigment epithelial detachment (PED) was observed in 15.5%, 39.29%, and 23.81% of the eyes, respectively. The mean interval of repeat injection was 10.2 ± 2.1 weeks. Three episodes of ocular adverse drug reaction were reported, including two patients developing subretinal hemorrhage while one having a retinal pigment epithelial (RPE) tear. Notably, no intraocular inflammation (IOI) was seen in any of the eyes, and no systemic side effects were identified. Conclusion: In a real-world scenario, brolucizumab therapy is efficacious and safe in the management of nAMD over the short term. Further long-term studies are warranted to validate these findings. Additionally, lack of ocular inflammation after 126 brolucizumab injections in our Indian data is peculiar and underlines the necessity to explore the role of race and genetics in predisposing to/safeguarding against brolucizumab-related IOIs.
Exploring RNAs Interactions and Polymorphisms in the Pathophysiology of Pemphigus: A Review

Background: Pemphigus consists of a group of rare autoimmune blistering diseases involving the skin and mucous membranes. Pemphigus pathophysiology is mediated by autoantibodies against two desmosomal cadherins, namely, desmoglein (Dsg) 1 and (Dsg) 3 that are present in the skin and mucosal membranes. The involvement of coding and non-coding RNAs in the pathophysiology of pemphigus has been studied in the literature. MicroRNAs are small RNAs that could also be used as diagnostic biomarkers for some autoimmune diseases. The aim of this research was to explore the potential of this specification of some RNAs to be used as biomarkers for diagnosing pemphigus or its severity. This review discussed RNA expressions in patients with pemphigus. Methods: A comprehensive search was performed on published studies from 1990 to May 2020 using different search engines including PubMed, Scopus, and Web of Science. Results: In general, 335 articles were obtained according to search keywords. Then, 41 relevant studies were selected based on the inclusion and exclusion criteria. MiR-338-3p, miR-424-5p, and miR-584-5p were among the miRNAs that were reported to be increased in pemphigus. The C3 mRNA, mRNA of CD36, mRNA of CD163, mRNA of urokinase plasminogen activator (PA), IL23R mRNA, RORγt mRNA, and human leukocyte antigen G1 (HLA-G1) mRNA were coding RNAs that increased in pemphigus in addition to the activity of the mRNA of tissue-type PA while HLA-G2 mRNA decreased in pemphigus. Conclusion: Overall, this study investigated the role of Mir-338-3p, miR-424-5p, MiR-127, miR-584-5p, and some mRNAs in pemphigus, and it was revealed that some RNAs may be impressive on pemphigus. More studies and clinical assessments need more information about the role of RNAs on pemphigus to obtain a better view of their mechanisms and use them as biomarkers for earlier diagnosis or probable treatment.
Identification of a Prognosis-Related Risk Signature for Bladder Cancer to Predict Survival and Immune Landscapes

Background Bladder cancer is the tenth most common cancer worldwide. Valuable biomarkers in the field of diagnostic bladder cancer are urgently required. Method Here, the gene expression matrix and clinical data were obtained from The Cancer Genome Atlas (TCGA), GSE13507, GSE32894, and Mariathasan et al. Five prognostic genes were identified by the univariate, robust, and multivariate Cox's regression and were used to develop a prognosis-related model. The Kaplan–Meier survival curves and receiver operating characteristics were used to evaluate the model's effectiveness. The potential biological functions of the selected genes were analyzed using CIBERSORT and ESTIMATE algorithms. Cancer Therapeutics Response Portal (CTRP) and PRISM datasets were used to identify drugs with high sensitivity. Subsequently, using the bladder cancer (BLCA) cell lines, the role of TNFRSF14 was determined by Western blotting, cell proliferation assay, and 5-ethynyl-20-deoxyuridine assay. Results GSDMB, CLEC2D, APOL2, TNFRSF14, and GBP2 were selected as prognostic genes in bladder cancer patients. The model's irreplaceable reliability was validated by the training and validation cohorts. CD8+ T cells were highly infiltrated in the high-TNFRSF14-expression group, and M2 macrophages were the opposite. Higher expression of TNFRSF14 was associated with higher expression levels of LCK, interferon, MHC-I, and MHC-II, while risk score was the opposite. Many compounds with higher sensitivity for treating bladder cancer patients in the low-TNFRSF14-expression group were identified, with obatoclax being a potential drug most likely to treat patients in the low-TNFRSF14-expression group. Finally, the proliferation of BLCA cell lines was increased in the TNFRSF14-reduced group, and the differential expression was identified. TNFRSF14 plays a role in bladder cancer progression through the Wnt/β-catenin-dependent pathway. TNFRSF14 is a potential protective biomarker involved in cell proliferation in BLCA. Conclusion We conducted a study to establish a 5-gene score model, providing reliable prediction for the outcome of bladder cancer patients and therapeutic drugs to individualize therapy. Our findings provide a signature that might help determine the optimal treatment for individual patients with bladder cancer.
Synthèse et caractérisation d'homostructures et d'hétérostructures de nanoplaquettes de chalcogénures de mercure

Dans un contexte de developpement de photo-detecteurs et lasers dans le domaine de l’infrarouge, les nanocristaux colloidaux de chalcogenures de mercure sont des candidats prometteurs pour l’imagerie infrarouge a bas cout. Des nanoplaquettes de chalcogenures de cadmium sont developpees depuis 10 ans. Ces nanoparticules 2D presentent des proprietes optiques originales dans le visible, du fait de leur confinement quantique limite a une di-mension. L’objectif de cette these est de syn-thetiser des nanoplaquettes a base de chalco-genures de mercure afin d’obtenir des proprie-tes optiques fines dans l’infrarouge. Pour cela, nous avons utilise l’echange cationique au mercure sur des nanoplaquettes de chalcoge-nures de cadmium, la synthese directe n’etant pas encore demontree.Dans une premiere partie, ce manuscrit expose la synthese et la caracterisation de nanopla-quettes fines de 2 et 3 monocouches de HgTe et HgSe. Les nanoplaquettes de HgTe presen-tent des proprietes optiques exceptionnelles dans le proche infrarouge (largeur a mi-hauteur de 57 meV pour une emission aux alentours de 1,5 eV). Par la suite, l’echange cationique sur des na-noplaquettes plus epaisses de CdSe a ete etu-die. La limitation de la diffusion des atomes de mercure sur 2 plans cationiques dans l’epaisseur permet d’obtenir des heterostruc-tures cœur/coque de CdSe/HgSe presentant des proprietes optiques et electroniques decor-relees.Pour finir, cet echange cationique a ete utilise pour creer de nouvelles heterostructures cœur/coque de HgTe/CdS et cœur/couronne HgSe/HgTe permettant de jouer sur la delocali-sation des fonctions d’onde des porteurs de charge.
Crack Identification Method of Steel Fiber Reinforced Concrete Based on Deep Learning: A Comparative Study and Shared Crack Database

As a common disease of concrete structure in engineering, cracks mainly lead to durability problems such as steel corrosion, rain erosion, and protection layer peeling, and then the building gets destroyed. In order to detect the cracks of concrete structure in time, the bending test of steel fiber reinforced concrete is carried out, and the pictures of concrete cracks are obtained. Furthermore, the crack database is expanded by the migration learning method and the crack database is shared on the Baidu online disk. Finally, a concrete crack identification model based on YOLOv4 and Mask R-CNN is established. In addition, the improved Mask R-CNN method is proposed in order to improve the prediction accuracy based on the Mask R-CNN. The results show that the average prediction accuracy of concrete crack identification is 82.60% based on the YOLO v4 method. The average prediction accuracy of concrete crack identification is 90.44% based on the Mask R-CNN method. The average prediction accuracy of concrete crack identification is 96.09% based on the improved Mask R-CNN method.