Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Histidine-rich Glycoprotein in Coagulation & Fibrinolysis

The fibrinolytic system has an important role in maintaining vascular patency by restricting fibrin clot formation to prevent occlusion of the blood vessel. Plasminogen activation is the central event in fibrinolysis and is tightly regulated by activators and inhibitors. Histidine-rich glycoprotein (HRG) is an abundant plasma protein that has been proposed to have a regulatory role in many biological processes, including fibrinolysis. Approximately 50% of plasminogen in the blood circulates in complex with HRG. Conflicting reports dispute the role of HRG in fibrinolysis, specifically whether it promotes or inhibits plasminogen activation. To elucidate the role of HRG in fibrinolysis, we isolated HRG from human plasma and analyzed its effect on plasminogen activation by tissue-type plasminogen activator in a kinetic assay. HRG had no significant effect on plasminogen activation by tissue-type plasminogen activator once contaminating plasminogen was eliminated from our HRG preparations. Based on these results, the focus of our research was redirected to analyzing the effect of HRG on additional plasminogen activators, namely urinary-type plasminogen activator and factor (F) Xlla. HRG inhibited plasminogen activation by both activators. HRG had the greatest inhibitory effect on FXIIa activity. This novel finding led us to explore the relationship between HRG and FX.IIa by measuring the affinity of HRG for FX.IIa by surface plasmon resonance, and by analyzing the effect of HRG on FXIIa activity in various contact pathway reactions. ZnCh was also included in these reactions because it plays an important role in enhancing both HRGand FXII-mediated interactions and is released by activated platelets. In the presence of 12.5 J.LM ZnCh, FXIIa bound to the histidine-rich region of HRG with very high affinity (~ = 56 ± 8.9 pM). Interestingly,
On Bayesian analysis of non-linear continuous-time autoregression models

In a daylight enlarger of the fixed focus type which comprises an enclosed image forming area having two arm-holes which allow an operator's hands to enter this area there being present a lamphouse and transparency holder placed above the image framing area but outside the enclosed area and an enlarging lens in the transparency holder there being present in the transparency holder between the transparency and the enlarging lens a movable inclined mirror which in a first position when the lamphouse is operating with a transparency in the holder reflects an erect illuminated image of the transparency away from the enlarger so that it can be viewed by the operator of the enlarger, but which in a second position is moved from beneath the transparency so allowing the illuminated image of the transparency to fall on the image framing area, there is provided means manually controllable from inside the enclosed image forming area of the enlarger to cause the inclined mirror to be moved out of the path of the light which passes through the transparency to the enlarging lens and thence to the image projection area so enabling print material present in the image forming area to be exposed.
On the cervical muscles of birds

Cervical muscles in eleven Orders and nineteen species of birds were compared by semidiagramatical illustrations of the lateral view. The main series of cervical muscles studied was given the following nomenclature:1. Dorsal muscles1. Biventer muscle, M. biventer cervicalis2. Dorsal long cervical muscle, M. longus colli posticus (M. spinalis)a. Longitudinal part, pars longus b. Anterior part, pars anteriorc. Posterior part, pars posterior d. Inferior part, pars inferior3. Dorsal profound cervical muscle, M. profundus colli posticus4. Intercrestal muscle, M. intercristalisII. Lateral muscles1. Oblique cervical muscle, M. obliquus colli2. Lateral cervical muscle, M. colli lateralis (M. intertransversalis)III. Ventral muscles1. Ventral long cervical muscle, M. longus colli anticusa. Longitudinal part, pars longus b. Anterior part, pars anteriorc. Posterior part, pars posteriorThe development of these muscles is extremely variable both adaptively and possibly taxonomically and in some groups is very specialized. These complexities of the avian cervical muscle system are the natural result of their variety of uses of the neck in food-getting and other activities. The myology of this interesting and important part of avian body, however, has been curiously neglected and is open to future detailed comparative studies.
Artificial Intelligence and Natural Language Processing and Understanding in Space: Four ESA Case Studies

The European Space Agency is well known as a powerful force for scientific discovery in numerous areas related to Space. The amount and depth of the knowledge produced throughout the different missions carried out by ESA and their contribution to scientific progress is enormous, involving large collections of documents like scientific publications, feasibility studies, technical reports, and quality management procedures, among many others. Through initiatives like the Open Space Innovation Platform, ESA also acts as a hub for new ideas coming from the wider community across different challenges, contributing to a virtuous circle of scientific discovery and innovation. Handling such wealth of information, of which large part is unstructured text, is a colossal task that goes beyond human capabilities, hence requiring automation. In this paper, we present a methodological framework based on artificial intelligence and natural language processing and understanding to automatically extract information from Space documents, generating value from it, and illustrate such framework through several case studies implemented across different functional areas of ESA, including Mission Design, Quality Assurance, Long-Term Data Preservation, and the Open Space InnoPreprint submitted to Engineering Applications of Artificial Intelligence October 10, 2022 ar X iv :2 21 0. 03 64 0v 1 [ cs . C L ] 7 O ct 2 02 2 vation Platform. In doing so, we demonstrate the value of these technologies in several tasks ranging from effortlessly searching and recommending Space information to automatically determining how innovative an idea can be, answering questions about Space, and generating quizzes regarding quality procedures. Each of these accomplishments represents a step forward in the application of increasingly intelligent AI systems in Space, from structuring and facilitating information access to intelligent systems capable to understand and reason with such information.
Spectral characteristics of the 1986 September 13 Kalamata (southern Greece) earthquake

SUMMARY The seismic source parameters seismic moment M,, source dimension r, fault length 1, average displacement (u), shear-stress drop Aa, radiated energy Es, and apparent stress n( a) are calculated for the Kalamata (southern Greece) earthquake of 1986 September 13. These source parameters are obtained by using teleseismic P and SH-wave spectra and making use of three independent spectral parameters, the long period spectral level a,, the corner frequency f,, and the parameter E which controls the high-frequency decay of the displacement spectrum. The calculated far-field spectra are based on the direct phases of Pand S-waves and they have been corrected for the instrumental response and for an average radiation pattern assuming normal faulting mechanism. The striking feature of the obtained results is the low stress drop value of about 6-7 bar which is in deviation from the average value (30 bar) for interplate earthquakes. A seismic moment of 1.9 x and 2.2 x loz4 dyne - cm, a fault length of about 22 and 11 km, and an average displacement.of 15 and 9 cm are obtained on the basis of P- and S-waves, respectively.
Technology in schools : education, ICT and the knowledge society

Many countries around the world are investing in Information and Communication Technologies (ICT) to improve and update the education they provide their younger generations. This document offers examples and insights to demonstrate that introducing ICT into the schools, without a proper staff development plan and without a pedagogical perspective, is a low-return investment. Technology is still expensive and requires constant support at the school level for hardware and network repairs and software configurations, updates and management. Relevant digital educational content, both from the Internet and from CDs is an important consideration that needs careful attention, especially in terms of addressing learning needs, teaching practices and models that may become critical factors inside the classroom. Implementing an ICT policy in education requires a long-term commitment from various levels of government; therefore, this report offers a few guidelines for program implementation in terms of management needs and program enhancement. A special section is devoted to ICT for small rural schools, which are common in developing countries and which require, and deserve, special attention in terms of staff development, technical support and relevant content for their students. In the final section, a number of implementation priorities are analyzed, including the profile of the ICT management team, its alignment with other national educational priorities, and the importance of human capacity building in terms of program scale, right from the beginning of the program. The paper ends with a resource base that can be used for further procurement of up-to-date information on ICT use in education.
An Update on the Molecular Pathology of Metaplastic Breast Cancer

Abstract Metaplastic breast cancer (MpBC) is a fascinating morphologic sub-type of breast cancer, characterised by intra-tumoural heterogeneity. By definition, these tumors show regions of metaplasia that can present as spindle, squamous, chondroid or even osseous differentiation. MpBC are typically triple-negative, and are therefore not targetable with hormone therapy or anti-HER2 therapies, leaving only chemotherapeutics for management. MpBC are known for their aggressive course and poor response to chemotherapy. We review herein the pathology and molecular landscape of MpBC and discuss opportunities for targetted therapies as well as immunotherapies.
Manipulating scattering features by metamaterials

We present a review on manipulations of electromagnetic scattering features by using metamaterials or metasurfaces. Several approaches in controlling the scattered fields of objects are presented, including invisibility cloaks and radar illusions based on transformation optics, carpet cloak using gradient metamaterials, dc cloaks, mantle cloaks based on scattering cancellation, “skin” cloaks using phase compensation, scattering controls with coding/programmable metasurfaces, and scattering reductions by multilayered structures. Finally, the future development of metamaterials on scattering manipulation is predicted.
Total Lightning Mapping using both VHF Interferometry and Time-of-Arrival Techniques

As part of Vaisala's technology and applications test bed in the Dallas-Fort Worth area in Texas, we have been operating two overlapping total lightning detection networks. One is based on the VHF Interferometry principle while the other is based on the VHF Time-of- Arrival principle. For the first time, these two technologies can be compared in a common region where they both exhibit good performance. The aim of the work presented in this paper is to evaluate the performance of these networks and compare the relative strengths of these two approaches for Total Lightning mapping.
Acceptance of a food of animal origin obtained through genetic modification and cloning in South America: a comparative study among university students and working adults

With the aim of comparing the acceptance of milk obtained from cloned, genetically modified (GM) and conventionally bred cows among working adults and university students, and identifying and characterizing typologies among both subsamples in terms of their preferences, a survey was applied to 400 people in southern Chile, distributed using a simple allocation among the subsamples. Using a conjoint analysis, it was found that consumers preferred milk from a conventional cow. Using a cluster analysis, in both subsamples two segments sensitive to production technology were identified. Rejection of cloning was greatest among university students, whereas a higher proportion of working adults rejected GM. The segments differed in terms of area of residence, knowledge about GM, and milk consumption habits. Contrary to what was expected, no differences were found according to education, gender or degree of satisfaction with food-related life.
Comparative Analysis of Brain Activation between Healthy Elderly Women and Healthy Adult Women

[Purpose] This study determined the differences in the brain activation between healthy elderly women (75.89 ± 6.44 years of age) and healthy adult women (22.11 ± 2.04 years). [Subjects] Twenty-seven healthy elderly women who could independent daily living with no history of brain diseases such as stroke or schizophrenia and 27 healthy adult women who are studying at S university in Busan were as participants in this study. [Methods] Examinations used twenty electrodes attached to the head to capture electrical brain signals during brain activated states such as the awaked state and the data were compared between the two groups of women. The AT index is the ratio of theta waves and SMR waves. The AC index is the ratio of alpha waves to low beta waves. The ST index is the ratio of high beta waves to alpha waves. The Mann-Whitney test was conducted to examine changes in EEG. [Results] Fp1, Fp2, Fz, F3, F4, F7, F8, and Pz areas indicate a significantly lower AT index in the healthy elderly women than in the healthy adult women. The Fp1, Fp2, Fz, F3, F4, F7, F8, Pz, P3, and P4 areas all showed a significantly higher AC index in the healthy elderly women, they who also had a significantly higher ST index than the healthy adult women in the Fz, F3, F4, F8, Pz, P3, and P4 areas. [Conclusion] We showed that the brain of the healthy elderly women lacks rest for processing information which is received during eyes open. We also demonstrated the capability of the quantitative EEG in the examination of cognitive impairments.
Properties of Monoclonal Antibodies to Potato Leafroll Luteovirus and Their Use to Distinguish Virus Isolates Differing in Aphid Transmissibility

Summary Ten murine monoclonal antibodies (MAbs) specific for a British isolate of potato leafroll luteovirus (PLRV) were produced in large quantities in ascitic fluids and their isotypes determined. All 10 MAbs reacted in indirect ELISA with intact PLRV particles but four did not react with disrupted virus particles, suggesting that these four MAbs are specific for epitopes dependent on quaternary structure. None of the MAbs gave a precipitin reaction in immunodiffusion tests. All the MAbs reacted strongly with, but failed to differentiate, 28 readily aphid-transmissible British PLRV isolates, six of which consistently caused symptoms differing in severity in indicator hosts. Two MAbs (SCR-8 and SCR-10) reacted only weakly with two other PLRV isolates, both of which were poorly transmissible by aphids. Three MAbs (SCR-6, SCR-8 and SCR-10) reacted with groundnut rosette assistor luteovirus (GRAV), but none reacted with British isolates of three other luteoviruses: carrot red leaf, beet western yellows and barley yellow dwarf (B and F isolates). Five epitopes on PLRV particles were distinguished, of which the two that were missing in the poorly aphid-transmissible isolates of PLRV and/or were shared with GRAV were both apparently dependent on quaternary structure.
International Journal of Innovative Science and Modern Engineering

Internet of things (IOT) made the world connected to each other through Internet. These gadgets are important to store data, to exchange data and to collect data from other sources. These devices are not perfectly capable to cooperate with data centers directly based on some parameters such as latency, resource availability, load balancing, scheduling and security. Fog computing (FC) paradigm is introduced to overcome the problems of these parameters. As it cooperate with centralized data centers. This paper presents a survey on Fog computing terminology. Here, the term fog computing has been discussed. Further its architecture, its challenges are highlighted. An overview of further research work related to dynamic job scheduling has been discussed.
Diagenetic pathways linked to labile Mg-clays in lacustrine carbonate reservoirs: a model for the origin of secondary porosity in the Cretaceous pre-salt Barra Velha Formation, offshore Brazil

Abstract The lacustrine carbonate reservoirs of the South Atlantic host significant accumulations of chemically reactive and Al-free Mg-silicate minerals (e.g. stevensite, kerolite and talc). Petrographic data from units such as the Cretaceous Barra Velha Formation in the Santos Basin suggest that Mg-silicate minerals strongly influenced, and perhaps created, much of the observed secondary porosity. The diagenetic interactions between reactive Mg-silicate minerals and carbonate sediments are, however, poorly known. Here we develop a conceptual model for the origin of secondary porosity in the Barra Velha Formation guided by considerations of the chemistry that triggers Mg-silicate crystallization, as well as the geochemical and mineralogical factors that act as prerequisites for rapid Mg-silicate dissolution during early and late diagenesis. We conclude that sub-littoral zones of volcanically influenced rift lakes would have acted as the locus for widespread Mg-silicate accumulation and preservation. Organic-rich profundal sediments, however, would be especially prone to Mg-silicate dissolution and secondary porosity development. Here, organic matter diagenesis (especially methanogenesis) plays a major role in modifying the dissolved inorganic carbon budget and the pH of sediment porewaters, which preferentially destabilizes and then dissolves Mg-silicates. Together, the sedimentological, stratigraphic and geochemical predictions of the model explain many enigmatic features of the Barra Velha Formation, providing a novel framework for understanding how Mg-silicate–carbonate interactions might generate secondary porosity more broadly in other lacustrine carbonate reservoirs across the South Atlantic.
Cognition & Emotion Reappraisal and Expected Value Modulate Risk Taking

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KURUMSAL YÖNETİM ENDEKSİ İLE ŞİRKET HİSSE SENEDİ GETİRİ İLİŞKİSİ: BIST'DE BİR UYGULAMA THE RELATION BETWEEN THE CORPORATE GOVERNANCE INDEX AND THE PROFIT OF COMPANIES' STOCKS: AN APPLICATION IN BIST

OZET: Calismanin amaci, kurumsal yonetim endeksine girisin sirket getirilerine etkisini incelemektir. BIST Kurumsal Yonetim Endeksi (XKURY), Kurumsal Yonetim Ilkeleri'ni uygulayan sirketlerin dahil edildigi endekstir. Bu amacla, 2012 ve 2013 yillarinda ilk defa BIST kurumsal yonetim endeksine alinan toplam 11 sirketin endekse girme tarihi ile bu tarihten 10 gun once ve 10 gun sonra olusan anormal getirileri hesaplanmistir. Calismada, anormal getiri elde edilip edilmeyecegini test etmek icin hipotezler olusturulmustur. Elde edilen sonuclara gore, olay tarihten 10 gun once ve 10 gun sonra olusan anormal getiriler karisik bir seyir izlemistir. Bazi gunler pozitif anormal getiriler elde edilirken, bazi gunler negatif anormal getiriler meydana gelmistir. Anahtar sozcukler: Kurumsal Yonetim, Kurumsal Yonetim Endeksi, Anormal getiri. Jel Siniflamasi: G30,G39,M48 ABSTRACT: The aim of the study is to investigate the positive aspects of enrolling Corporate Governance Index. BIST corporate Governance Index (XKURY) is the index in which the companies that apply Corporate Governance Principles are included. For that purpose, the abnormal gainings that accured 10 days before and after the companies enrolling Corporate Governance Index are calculated. Those are totally eleven companies which are accepted firstly to the BIST Corporate Governance Index in 2012 and 2013. Hypotyzes have been formed for testing whether abnormal gainings are obtained or not. According to the resutls, the abnormal gainings have shown irregular trend 10 days before and after the event. Somedays while positive gainings are observed some other days the opposite is occured.
In situ X‐ray observations of phase assemblages in peridotite and basalt compositions at lower mantle conditions: Implications for density of subducted oceanic plate

[1] Phase relationships in KLB-1 peridotite, normal-type mid-oceanic ridge basalt (NMORB) and K-rich basalt compositions were investigated experimentally from 28 to 143 GPa and 2050 to 3000 K. A laser-heated diamond anvil cell with the synchrotron X-ray diffraction was developed to perform in situ observations of samples at simultaneous high pressures and temperatures. We confirmed that the peridotite composition crystallized into an assemblage of Mg perovskite + Ca perovskite + magnesiowustite at pressures below 97 GPa and that NMORB and K-rich basalt compositions both crystallized as Mg perovskite + Ca perovskite + stishovite + an aluminous phase with a CaFe2O4-type structure at pressures below 68 GPa. The orthorhombic Mg perovskite is stable in natural rock compositions at pressures less than 97 GPa, corresponding to about 2200 km depth. Phase transition of silica phase from stishovite to CaCl2-type phase was observed at 78 GPa in NMORB composition. Moreover, we observed that NMORB crystallized in to an assemblage of CaIrO3-type (Mg,Fe)SiO3 + Ca perovskite + α-PbO2-type silica + an aluminous phase with a calcium CaTi2O4-type structure at 143 GPa, corresponding to the core-mantle boundary depth. We measured the unit cell volumes of minerals in the NMORB composition at high P-T and thereby estimated the density of subducted MORB to a depth of 1800 km in the lower mantle. In this depth regime, MORB is denser than model mantle densities, e.g., PREM and AK135. The estimated density of MORB may contribute to an understanding of dynamics of the subducted slab in the deep lower mantle.