Miracle-dz/UniFAR-FTUs huggingface dataset:
Efektivitas antibakteri ekstrak etanol daun melinjo (Gnetum gnemon L.) terhadap bakteri Escherichia coli

Melinjo ( Gnetum gnemon L .) merupakan salah satu tanaman yang daunnya dapat digunakan sebagai antibakteri pada masalah diare karena daun melinjo mengandung alkaloid, flavonoid, saponin dan tanin. Salah satu penyebab diare adalah bakteri Escherichia coli . Tujuan penelitian ini untuk mengetahui aktivitas dan efektivitas antibakteri ekstrak etanol daun melinjo terhadap bakteri Escherichia coli. Penelitian ini termasuk jenis penelitian eksperimental yang dilakukan di Laboratorium Mikrobiologi dan Laboratorium Farmakognosi Akademi Farmasi Putra Indonesia Malang. Penelitian ini menggunakan metode difusi sumuran dengan konsentrasi 10% b/v, 20% b/v, 30% b/v, 40% b/v, 50% b/v, 60% b/v, 70% b/v, 80% b/v, 90% b/v, dan 100% b/v. Hasil penelitian menunjukkan bahwa ekstrak etanol daun melinjo dapat menghambat pertumbuhan bakteri Escherichia coli . Konsentrasi yang efektif sebagai antibakteri terhadap Escherichia coli terdapat pada konsentrasi 90% b/v. Kesimpulan dari penelitian ini ekstrak etanol daun melinjo (Gnetum gnemon L) memiliki aktivitas dan efektivitas antibakteri terhadap bakteri Escherichia coli .
Linked Attention-Based Dynamic Graph Convolution Module for Point Cloud Classification

With the rapid development of 3D technology, point cloud data is becoming more and more popular, which arouses researchers’ interest. But its properties – irregularity and disorder – make it difficult to analyze. In this work, we combine the attention module with the dynamic graph convolutional neural network to pay attention to the target’s critical part. Then, the modules are densely connected to guarantee that each layer is fully utilized. Finally, we carry out experiments on several benchmark datasets to verify the proposed model and achieve state-of-the-art performance.
Application of Metal-Organic Framework-Based Composites for Gas Sensing and Effects of Synthesis Strategies on Gas-Sensitive Performance

Gas sensing materials, such as semiconducting metal oxides (SMOx), carbon-based materials, and polymers have been studied in recent years. Among of them, SMOx-based gas sensors have higher operating temperatures; sensors crafted from carbon-based materials have poor selectivity for gases and longer response times; and polymer gas sensors have poor stability and selectivity, so it is necessary to develop high-performance gas sensors. As a porous material constructed from inorganic nodes and multidentate organic bridging linkers, the metal-organic framework (MOF) shows viable applications in gas sensors due to its inherent large specific surface area and high porosity. Thus, compounding sensor materials with MOFs can create a synergistic effect. Many studies have been conducted on composite MOFs with three materials to control the synergistic effects to improve gas sensing performance. Therefore, this review summarizes the application of MOFs in sensor materials and emphasizes the synthesis progress of MOF composites. The challenges and development prospects of MOF-based composites are also discussed.
Amomum compactum Soland ex Maton ADDITION AS ESSENTIAL OIL SOURCE AND ITS EFFECT ON RUMINAL FEED FERMENTATION BY IN VITRO ANALYSIS

Essential Oil (EO), as feed additive, has positive effect on ruminal feed fermentation by increasing feed efficiency and reducing methane production. This research was done to studied java cardamom ( Amomum compactum Soland ex Maton) effect, be essential oil source as feed additive, on ruminal feed fermentation. In vitro gas production technique was used in this research to elaborate the effect of cardamom on nutrient digestibility of substrate and parameters of fermentation in rumen. Cardamom meal was added into feed sample equal to end concentration of EO in fermentation medium as much as 0, 25, 50, 75 and 100 mg/l. Substrate of fermentation consist of Pennisetum purpureum , rice bran and wheat pollard. Addition of cardamom have no effect on substrate dry matter digestibility except at 100 mg/l was decreased. Protein digestibility in all added cardamom fermentation were lower than control, whereas organic matter and crude fiber digestibility increased up to 13.5 and 24% at level of EO 100mg/l respectively. Fermentation parameters including volatile fatty acid (acetate, propionate, butyrate) production, pH and microbial protein synthesis did not affected by cardamom addition except ammonia concentration. Methane production and protozoa population also did not change by the treatment. In conclusions of this study that, utilization of java cardamom as feed additive have positive effect on ruminal feed fermentation by increase organic matter and crude fiber digestibility and reduce protein digestibility.
Optically Activatable Double-Drug-Loaded Perfluorocarbon Nanodroplets for On-Demand Image-Guided Drug Delivery

: Phase-changing nanodroplets have been studied as externally activatable in situ microbubble precursors. The nanodroplets can be triggered to vaporize with an external optical or acoustic energy source, and the resulting microbubbles can be visualized with high sensitivity using ultrasound imaging. Because of their nanoscale size, this type of construct is attractive for the encapsulation and on-site, on-demand release of therapeutics. Here, we develop a double-drug loaded nanodroplet platform that can coencapsulate paclitaxel and doxorubicin, and release them upon external laser activation. Nanodroplets are characterized in terms of size, stability, protein interaction, and drug release. Their capacity to concurrently release the two drugs and generate ultrasound contrast is demonstrated in vitro. The e ﬃ cacy of dual-drug loaded nanodroplets is compared in vitro with that of free drug formulations, and potential mechanisms of their enhanced cytotoxic behavior are explored. Overall, the results show that the nanodroplets are a versatile platform for on-demand image-guided drug delivery.
New information on multispherulitic dinosaur eggs: Faveoloolithidae and Dendroolithidae

ABSTRACT Dinosaurs produced a broad range of different types of eggs. Some of which have no analogue among those laid by living reptiles and birds. Eggs with shell units branching into an unusual labyrinth associated with a complicated pneumatic system were assigned to the parataxonomic oofamilies Faveoloolithidae and Dendroolithidae. While numerous new related ootaxa were described recently, many biological aspects as well as the identity of their producers have remained unknown or unresolved. Here, we provide the first experimental evidence that some mid-sized dendroolithid eggs were laid by a therizinosauroid theropod. We scanned and studied two faveoloolithid eggs. One of them contains putative embryonic remains that correspond to an articulated cranial skeleton exhibiting rather reduced antorbital region/opening similar to that in titanosaurian embryos. Another faveoloolithid egg exhibits unusual bending of the uninterrupted shell; we discuss three alternative interpretations: natural deformation, pathology and pliability, to explain this unusual phenomenon.
Mass and Number and Its Chemical Composition Distribution of Particulate Matter in Different Microenvironments

Adverse health effects from exposure to air pollution are a global challenge and of widespread concern. Therefore, the present study attempted to pave the way in the study of indoor air pollution by coarse and fine particulate matter and picturesque its relation with the different indoor microenvironment. A campaign study was conducted in the city of Taj “ Agra, ” India in which different microenvironments were selected (i.e., offices, shops, and commercial centers). For each site, two different locations were chosen to examine the coarse particles (PM 10 and PM 5.0 ) and fine particles (PM 2.5 , PM 1.0 , PM 0.5 and PM 0.25 ) concentrations and metal concentration of Zn, Pb, Ni, Fe, Cr, Cd, Mg and Cu in PM 2.5 and for their related health effects. The exposure factor and health risk assessment for carcinogenic effects due to heavy metal contaminants have also been calculated for adults working in different microenvironment by following the methodology prescribed by US EPA.
Fossil fuels, climate change, and the COVID-19 crisis: pathways for a just and green post-pandemic recovery

ABSTRACT A climate-positive COVID-19 recovery can accelerate the energy transition away from fossil fuels. Yet, current assessments of recovery stimulus programs suggest that the most fossil fuel producers are more likely to take on a ‘dirty’ recovery path out of the pandemic than a ‘green’ one. Such a path will postpone climate action and entrench fossil fuel dependence. To change course, fossil fuel producers have to get on board of a 'green recovery'. For this, cooperative international efforts mobilizing both fossil fuel consumers and producers need to promote ‘just transition’ policies that increase support for a green shift among fossil fuel companies and producing countries, including fossil fuel exporters. In turn, fossil fuel producers should leverage the opportunity of stimulus packages to reduce their fossil fuel production dependence and help accelerate an energy transition through supply-side measures. A combination of ‘green’ investments and ‘just’ transition reforms could help enroll fossil fuel producers into a climate-friendly post-COVID recovery. Key policy insights Fossil fuel producers have mostly promoted ‘dirty’ rather than ‘green’ recovery paths from the COVID-19 pandemic A green recovery agenda requires a ‘just’ transition component to entice and support fossil fuel producers Both demand and supply-side strategies are required to advance a ‘just transition’ agenda throughout the post-COVID 19 recovery The post-COVID-19 transition requires energy policies responding to the constraints of consumer and producer countries to address climate and equity challenges
Fire in the belly: the impact of despotic leadership on employees work-related outcomes in the hospitality setting

Purpose Building on conservation of resources theory and unfolding theory of turnover, this paper aims to propose a model of the effects of despotic leadership on employees’ job satisfaction and turnover intention in the hospitality industry. In this model, the authors theorize psychological distress to play an intervening role among the aforesaid linkages. Design/methodology/approach The data were collected in three-waves from 212 employees working in Palestinian restaurants. A covariance-based matrix in structural equation modeling was used to verify the proposed linkages in the study. A marker variable was used to control the common method bias. Findings The results showed that despotic leadership has a direct negative effect on job satisfaction and a positive indirect effect on turnover intentions. Besides, psychological distress showed to play significant mediating effects among the aforementioned relationships. Practical implications This study gives insights to the hospitality industry on how despotic leadership can be destructive and lead to negative consequences. Originality/value This study is unique, as it is the first study conducted on despotic leadership in a hospitality setting. The study responded to scholarly calls made to enrich the literature pertaining to despotic leadership and its outcomes.
Mécanotransduction des cellules souches de glioblastome dans un nouveau modèle de culture tridimensionnel : implication de la MGAT5 dans la perception de l'environnement mécanique

Les cellules souches de glioblastomes (GSC) sont sensibles aux proprietes mecaniques de leur microenvironnement et utilisent la rigidite pour favoriser leur invasion.Dans ce contexte, nous avons developpe une matrice 3D fibrillaire artificielle permettant de recapituler in vitro les comportements migratoires observes in vivo. Cette matrice etant hautement plastique, nous avons pu moduler la rigidite, la chimie de surface ou encore l'alignement des fibres.Dans un premier temps nous avons modifie leur chimie de surface grâce a l’ajout de proteines de la matrice extracellulaire (MEC) puis depose des neurospheres (NS) de GSC sur ce tissu artificiel. L’ajout de laminine nous a permis d’observer le passage d’un comportement migratoire collectif a individuel.Dans un deuxieme temps nous avons module la rigidite des fibres. Apres cinq jours de migration des GSC dans differentes conditions de rigidites, nous avons constate une augmentation de la vitesse de migration a la rigidite intermediaire de 166kPa par rapport a la condition plus souple de 3,2 kPa et a la condition plus rigides de 1260kPa. Cette capacite migratoire maximale dans nos conditions est associee a des changements de morphologie des GSC, a une augmentation de l'expression des proteines associee a la transition epithelio-mesenchymateuse (EMT) et a une modification de la regulation des proteines des adherences focales.La surexpression de Mannoside acetyl glucosaminyltransferase 5 (MGAT5) est associee aux tumeurs malignes et est impliquee dans la formation de regroupement de proteines membranaires grâce a la formation d’un treillis. Elle favorise egalement la maturation des adherences focales, la migration cellulaire, l'invasion et l’EMT, entrainant ainsi des avantages fonctionnels pour les cellules tumorales. Au vu des resultats precedents sur l'expression des proteines EMT et des modifications de la regulation des proteines des adherences focales, nous avons genere des GSC n’exprimant plus la MGAT5 grâce a la technique CRISPR Cas9 et les avons placees en NS sur les matrices 3D presentant differentes rigidite. Nous avons alors observe une diminution de la vitesse de migration a 166kPa par rapport aux GSC controles, associee a une diminution de l'EMT et de la maturation des adherences focales. Par consequent, cette etude demontre l'implication de la glycosylation et plus particulierement de la glycosylation mediee par la MGAT5 sur la mecanotransduction des GSC.
A Fast Lithium-Ion Battery Impedance and SOC Estimation Method Based on Two-Stage PI Observer

Due to the complex changes in battery state, the accurate and fast estimation of battery state of charge (SOC) is still a great challenge. Here, a fast estimation method of battery impedance and SOC based on a multi-level PI observer is proposed. The observer model reflects the change of the battery state characteristics through the dynamic impedance, and then the system compensation factor is added to the observer to dynamically adjust the parameters of the battery model. The effectiveness of the algorithm is verified by the compound dynamic stress test (DST) experiment. The results show that the introduction of the compensation factor enables the system to tolerate a certain degree of impedance fluctuation and capacity attenuation and the maximum SOC estimation error can be kept within 2%.
Bioinformatic Analysis: The Role of LINC00634 in Colorectal Carcinoma

Background: LINC00634 is highly expressed in esophageal cancer, and its depletion can suppress the viability and induce the apoptosis of esophageal cancer cells. However, there is a lack of studies that examine the relationship between LINC00634 expression and the clinicopathological features, survival outcomes, prognostic factors and tumor immune cell infiltration of colorectal carcinoma (CRC) patients.Objective: We aim at investigating the role of LINC00634 in colorectal carcinoma.Methods: We obtained data from the TCGA (The Cancer Genome Atlas) public database, GTEx (Genotype-Tissue Expression) database and clinical samples. Wilcoxon rank-sum test, Kruskal-Wallis test and logistic regression analysis were employed to assess the relationship between LINC00634 expression and the clinicopathological characteristics of CRC patients. Receiver operating characteristic (ROC) curve was constructed to evaluate the ability of LINC00634 for distinguishing between CRC patients and normal subjects based on the area under the curve (AUC) score. Univariate and multivariate analyses were conducted to evaluate the association between prognostic factors and survival outcomes. Kaplan-Meier curves and Cox regression analysis were employed to determine the contribution of LINC00634 expression to the prognosis of colorectal carcinoma patients. Immune infiltration analysis and Gene Set Enrichment Analysis (GSEA) were conducted to identify the significantly involved functions of LINC00634. Finally, a nomogram was constructed for internal verification based on the Cox regression data.Results: The expression of LINC00634 was upregulated in CRC patients, and markedly associated with N stage, residual tumor, pathological stage, and overall survival (OS) event. ROC curve showed that LINC00634 had strong diagnostic and prognostic abilities (AUC=0.74). The high expression of LINC00634 could predict poor disease specific survival (DSS; P=0.008) and poor overroll survival (OS;P<0.01). The expression of LINC00634 was independently associated with OS in CRC patients (P=0.019). GSEA and immune infiltration analysis demonstrated that LINC00634 expression was involved in gene transcription, epigenetic regulation and the functions of certain types of immune infiltrating cells. The c-index of the nomogram was 0.772 (95％CI: 0.744-0.799). Conclusions: Our study reveals that LINC00634 can serve as a potential prognostic biomarker for CRC patients.
Gamification for Brand Value Co-Creation: A Systematic Literature Review

Gamification, commonly defined as the use of game elements in non-game contexts, is a relatively novel term, yet it has been gaining popularity across a wide range of academic and industrial disciplines. In the marketing field, companies are increasingly gamifying their mobile apps and online platforms to enrich their customers’ digital experiences. Whilst there has been a number of systematic studies examining the influence of gamification on user engagement across different fields, none has reviewed its role in brand value co-creation. Following a systematic literature review procedure via the online research platform EBSCOhost, this paper is the first to survey a set of empirical studies examining the role and impact of gamification on brand value co-creation. A final pool of 32 empirical studies implies the existence of four types of activities that are co-created by online users and positively influenced by gamification, namely: customer service, insights sharing, word-of-mouth, and random task. Moreover, this paper highlights the major game dynamics driving these activities, the key findings of each of the covered studies and their main theoretical underpinnings. Lastly, a set of noteworthy research directions for future related studies are suggested, comprising the exploration of novel game elements, and new co-creation activities related to corporate social responsibilities and physical commercial operations.
De nouveaux biocatalyseurs hétérogènes pour des réactions d'oxydation : des cristaux de métalloenzymes artificielles

Depuis la revolution industrielle, la chimie ne cesse de prosperer en developpant des procedes de plus en plus performants souvent aux depens de l’environnement. Dans le cadre du developpement d’une chimie durable, des procedes catalytiques dans le domaine de la chimie d’oxydation sont mis en place en utilisant des metaux physiologiques et des oxydants doux. En combinant les avantages de la catalyse homogene et de la biocatalyse, de nouveaux catalyseurs bio-inspires ont emerge, les metalloenzymes artificielles. Elles sont constituees d’un complexe inorganique, choisi en fonction de la reaction visee, qui est ancre au sein d’une proteine, qui apporte la selectivite de la reaction. Au cours des travaux de cette these, de nouvelles metalloenzymes artificielles ont ete creees par ancrage de divers complexes de Fe ou de Ru au sein de la proteine NikA. Dans un premier temps, l’hybride NikA/Ru-bpza a ete synthetise pour realiser l’hydroxychloration d’alcenes en presence d’un iode hypervalent. Bien que d’excellentes proprietes catalytiques aient ete obtenues, l’amelioration de la stabilite de ce type de catalyseurs, en particulier pour des reactions d’oxydation, reste un challenge important a relever pour leur utilisation au niveau industriel. Une des solutions originale est basee sur le developpement de la catalyse heterogene, en utilisant de cristaux de metalloenzymes artificielles grâce a la technologie CLEC (Cross-Linked Enzyme Crystals). Cette technologie permet, d’une part, d’ameliorer la stabilite et la recyclabilite des catalyseurs, et d’autre part, d’elargir les conditions reactionnelles utilisees (solvants, pH, temperatures). Trois reactivites ont ete developpees a base de CLEC NikA/FeL : (i) la sulfoxydation de thioethers, (ii) l’hydroxychloration d’alcenes en presence d’Oxone® et de chlore et (iii) la coupure oxydante d’alcenes par activation d’O2. Ces resultats ont permis d’explorer de nouvelles reactivites en chimie cascade soit en combinant les CLEC mis au point, soit en combinant differents catalyseurs homogenes.
MicroRNA Profiling Reveals an Abundant ssc-miRNA-148a-3p that Promotes Proliferation and Differentiation during Intramuscular Adipogenesis in Chinese Guizhou Congjiang Pigs Breeds by targeting PPARGC1A

BackgroundIntramuscular fat development is regulated by a series of complicated processes, and non-coding RNA (ncRNA) such as microRNA (miRNA) plays a critical role during intramuscular preadipocyte proliferation and differentiation development in pigs. In present research, we detected the expression profiles of miRNA during different differentiation stages, namely, day 0 (D0), day 4 (D4), and day 8 (D8), of intramuscular preadipocytes from the longissimus dorsi muscle of Chinese Guizhou Congjiang pigs to provide first insights into their potential involvement in intramuscular preadipocyte development. And we investigated the function of miR-148a-3p in adipocyte proliferation, apoptosis, and differentiation. ResultsA total of 67, 95, and 16 differentially expressed (DE) miRNAs were detected between D4 and D0, between D8 and D0, and between D8 and D4, respectively. We further characterized the role of miR-148a-3p which was differentially expressed and highest expressed abundance in D0, D4, and D8. To explore the role of miR-148a-3p in porcine intramuscular preadipocyte, miR-148a-3p mimics and inhibitors were used to perform miR-148a-3p overexpression and knockdown, respectively. Overexpression of miRNA-148a-3p increased the number of intramuscular preadipocytes in the S/G2 phase of the cell cycle and decreased the proportion of cells in the G0/G1 phase. Moreover, it promoted proliferation by regulation of cyclin B, cyclin G1, cyclin D1, CDK2, CDK3, and CDK4 and inhibited apoptosis of intramuscular preadipocyte by regulating the expression of Caspase-3, Bax, and Bcl-2. Meanwhile, the mimics of miR-148a-3p dramatically promoted intramuscular preadipocyte differentiation and upregulated the expression levels of adipogenic marker genes PPARγ, FASN, FABP4, HSL, APOE, LPL, and CEBPα. Furthermore, miR-148a-3p promoted intramuscular preadipocyte differentiation via restraining the AMPK/ACC/CPT1C signaling pathway. PPARGC1A was identified as a target gene of miR-148a-3p by luciferase activity and western blotting assays. ConclusionOur study provides novel insights into the regulatory mechanisms underlying intramuscular preadipocyte development and identified amount of miRNAs whose regulatory potential will need to be explored in the future. Our results establish that miR-148a-3p promoted adipocyte differentiation by targeting PPARGC1A.