Miracle-dz/UniFAR-FTUs huggingface dataset:
P030. Development of small bowel tissue phantom for microultrasound investigation

Background: The importance of mesenchymal cells in inflammation and/or neoplastic transformation is well recognised.1,2,3 However, both their role in the initiation of these processes and the molecular mechanisms underlying them, particularly in the intestine, remain elusive. Methods: We generated mice with a deletion of IKK2 in intestinal mesenchymal cells (IMCs) and subjected them to chemically induced mouse models of colitis (DSS) and colorectal carcinogenesis (AOM/ DSS, repeated AOM injections) or crossed them with the APC1638N/+ model of intestinal tumourigenesis. We collected intestinal tissue at different time points and evaluated tissue damage and inflammatory infiltration, measured tumour incidence, number, and size; assessed proliferation and apoptosis; and performed immunohistochemistry, Western blot analysis; and organ cultures. We also isolated IMCs and performed biochemical analysis. Results: We show that IMC-specific deletion of IKK2 leads to amelioration of DSS colitis and protects against colitis-associated but not spontaneous intestinal tumourigenesis. We further demonstrate that in colitis-associated cancer, IMC-specific IKK2 is critically involved in the initiation stage of the disease, because, in its absence, mice develop reduced immune cell infiltration, epithelial cell proliferation, apoptosis, and dysplasia. Conditional knockout mice further show reduced pro-inflammatory cytokine and chemokine production, including IL-6, and reduced STAT3 activation at these early time points. In-vitro studies demonstrate that IKK2-deficient IMCs display defective innate immune signalling, as shown by decreased NF-κB activation and reduced expression of NF-κB-induced soluble mediators, which affect STAT3 activation in epithelial cells. Conclusions: Collectively, our data show that deletion of IKK2 in IMCs has a protective role in intestinal inflammation and inflammation-driven carcinogenesis. Intestinal mesenchymal cells sense tissue damage and respond to produce pro-inflammatory and tissueremodelling molecules. These secondary signals attract and activate inflammatory cells establishing a pro-inflammatory milieu in the microenvironment and further support neoplastic cell proliferation through downstream activation of the STAT3 signalling pathway thus promoting tumour development.
Nutraceutical and Food Processing Properties of Millets: A Review

Millet grains have substantial benefits as a draught resistant crop, yield good productivity in the areas with water scarcity, possesses remarkable edible & nutritive values, and ease of processing & food manufacturing. Agriculture & Food security policymakers of developing countries should give due attention in promoting the research work & projects for studying the processing, food manufacturing, improvement in nutritive values and potential health benefits of the millet grains to promote their utilization as food in respective countries. Most of the developing countries have already started working in the field of improvement of edible potential of millet grains. Millet oil could be a good source of linoleic acid and tocopherols. Millet is an alkaline forming grain that is gluten-free. Millets are also rich sources of phytochemicals and micronutrients, play many roles in the body immune system. Millets have nutraceutical properties in the form of antioxidants which prevent deterioration of human health such as lowering blood pressure, risk of heart disease, prevention of cancer and cardiovascular diseases, diabetes, decreasing tumor cases etc. Other health benefits are increasing the time span of gastric emptying, provides roughage to gastro intestine. Millet is an alkaline forming food. Alkaline based diet is often recommended to achieve optimal health. In developing country, cereal-based foods have low bioavailability of minerals like iron, zinc initiate critical problem for infants and young children. Food processing techniques are used to enhance nutritional quality, improve the digestibility and bioavailability of food nutrients with reducing anti-nutrients. This study undertakes to concern and developing specific agenda for these crops which must be recognized as an important food and introduce the millets as a nutritious food, fulfillment of the nutritional need of global population and combat malnutrition. Gluten- free diseases, short growing season as compared to other major cereals Due to above mentioned advantageous characteristics; millet grains are receiving specific attention in the developing countries (like India, China & some countries from Africa Continent) in terms of utilization as food. Some developed countries are also giving due attention to millet grains in terms of its good potential in the manufacturing of bioethanol and biofilms Millets are important food crop in developing countries. Millets contain major and minor nutrients in remarkable amount. This study emphasized on millet recognized as high-energy nutritious food to help in reducing malnutrition, nourishing the common population and to help in preventing and curing the diseases like obesity, diabetes, CVD, etc. Millet is gluten-free food. Millet can be a substitute for celiac patients.
A Survey on Diabetes Mellitus in Chittagong Metropolitan Area, Bangladesh

The incidence of diabetes mellitus is increasing at an alarming proportion and majority of them are type-2 (Non-insulin dependent) diabetes mellitus. Two major concern are that much of this increase in diabetes will occur in developing countries due to population growth , ageing, unhealthy diets, obesity and sedentary life-styles and that there is a growing incidence of type-2 (Non-insulin dependent) diabetes mellitus which accounts for about 90% of all cases at a younger age. The objective of this study was to determine the prevalence of diabetes mellitus in consideration of age, sex, and socioeconomic status and also determine the present therapeutic management of diabetes and related complication having by the patients. In this survey a cross sectional observational community based study was conducted from August 2 to October 10, 2019 in Chittagong medical college hospital of Bangladesh. Among 100 diabetic hospitals going participants of different aged whose are visited to Chittagong medical college hospital to diagnosis diabetes were considered for the study. From all of 100 participants data were collected by using questionnaires. The questionnaire included socio-demographic data like- sex, age group, marital status, educational level and family history of diabetes etc. Clinical data included possible risk factor such as cardiovascular problem and obesity list of the all medication are also taken. I have taken the interview of 100 diabetes patients as a result among them 29% are male patients and 61% are female patients. So it is seen that female are more affected than male in both type-1 (insulin dependent) and type-2 (non-insulin dependent) diabetes mellitus patients . from the survey work it was found that increase of type-2 (Non-insulin dependent) diabetes mellitus patients 43% use metformin as oral hypoglycemic drugs 23% glimepride + metformin, 14% use gliclazide, 10% use linagliptin and 6% use sitagliptin + metformin . in case of insulin dependent (Type-1) diabetes mellitus 26% diabetes patients encounters were treated with insulin. In case of diabetes mellitus among 100 patients 32% are suffered from blood pressure, 33% are suffered from joint pain, 30% are suffered from Retinopathy, 15% are suffered from Back Pain, 7% are suffered from Foot Pain, 10% are suffered from Itching, 7%% are suffered from Frequent Urine, 20% are suffered from Chest Pain, 3%% are suffered from Arthritis and 9% are suffered from Allergy. From the survey work, it was seen that mainly three category patients were observed and 8% were low status, 80% people were medium status and 12% people were high status out of 100 diabetes patients as a sample.
New Determination of the Value of Vocational and Higher Education? Employees’ Educational Choices, Careers and Labour Market Outcomes in Germany

This paper aims to evaluate the adequacy of employees’ job requirements compared to their qualification and to identify typical qualification sequences and career paths in the commercial field. The results aim to contribute to the debate on the relevance of vocational qualifications in the labour market, driven by the trends of academisation in some occupational fields. The analyses are carried out based on the data from the follow-up survey to the BIBB/BAUA Employment Survey of 2018. With regard to qualification-adequate employment, the results show sector-specific differences. Overall, qualification adequacy is higher in the tourism and banking sectors than in trade and logistics. The quantitative analysis of typical training sequences in the four sectors also confirms the important significance of professional career paths in trade and logistics.
The correlation between imaging expression of P16 and S100 in hypertrophic ligamentum flavum

Background Lumbar spinal stenosis (LSS) is a common degenerative disease, which can lead to neurological dysfunction and requires surgical treatment. In the previous study, we used H&E staining and immunohistochemistry to qualitatively analyze the expression of S100 and P16 in the pathological process of ligamentum flavum (LF) hypertrophy in patients with LSS. To further explore the relationship between P16, S100 and LF hypertrophy in patients with LSS, we quantitatively detected S100 and P16 and their expressed products based on molecular biology techniques, and analyzed their imaging correlation. Methods Before posterior lumbar surgery, LF thickness was measured by Magnetic Resonance Imaging (MRI). Through the operation, we obtained the specimens of LF from 120 patients, all of whom were L4/5 LF. They were designated: simple lumbar disc herniation (LDH), single-segment spinal stenosis (SLSS), and double-segment LSS (DLSS). The detection of each side of LF was assessed. S100 and P16 and their expression products were detected by western blot and quantitative polymerase chain reaction (qPCR). Results The dorsal mRNA expression of P16 in DLSS group was significantly higher than that in SLSS group. On the dorsal and dural side of LF, the expression of P16 mRNA and proteins in the LDH group was significantly lower than that in SLSS and DLSS groups. We found a correlation between the thickness of LF and the expression of P16. However, there was no significant difference in the expression of S100 mRNA and S100 protein on both sides of the ligament and among the three groups, and no significant correlation between the expression of S100 and the thickness of LF. Conclusions P16 is involved in the process of LF hypertrophy in patients with LSS, and the imaging thickness of LF is related to the expression of P16. S100 may not be related to the hypertrophy of LF in patients with LSS, and there is no correlation between the imaging thickness of LF and the expression of S100. double-segment spinal stenosis, MRI: Magnetic Resonance Imaging, qPCR: quantitative Polymerase Chain Reaction.
PISB Control of Single Phase Cascaded Quasi ZSI DC-DC Converter

: The Z-source inverters are recent topological options proposed for buck–boost energy conversion with a number of possible voltage- and current-type circuit. This paper presents new step-up DC-DC converter topologies with improved efficiency, nearly nine fold increased gain, over two fold boost factor and reduced ripple free output, the topology contains cascaded quasi ZSI (Impedance Source Inverter) which has one diode, three capacitors, four inductors are used to maintain continuous current on the primary side for reducing energy losses in the output, a single phase isolation transformer and a voltage doubler rectifier (VDR). There are two operating modes shoot-through (ST) and non-shoot through (NST) modes. For controlling quasi ZSI (impedance source inverter), Pulse Width Modulation (PWM) with duty cycle ratio control method is used. By implementing the proportional Integral based Simple boost control (PISB) technique is achieved in quasi ZSI (impedance source inverter), voltage boost factor and component stresses are considerably reduced and ripple in the output voltage are prominently reduced when compared to the conventional method, single stage quasi dc to dc converter.
Stock Pattern Mining and Correspondence Analysis Based on Association Rules

In this paper, association rules were applied to mining patterns in stock K-line trend. The pattern which ordinary investors interested in is defined as T-RG (Three-Red Guards). In the mining process, we take the K-line in A-share markets as objects. Through the analysis, investors can select the appropriate point of purchase and selling point. With the help of T-RG, investors can better improve the chance of short-term investment success in A-share markets. In order to explore and validate the T-RG, the main contents of this paper include the following aspects: putting forward a method that judge the validity of rules based on confidence-lift; proposing the meta rule that corresponds to the pattern of T-RG; developing a computer program to extract the T-RG using MATLAB, which supports batch mining; leading fundamental factors into correspondence analysis with identification indexes; reminding the selected stocks, so as to verify the reliability of the identification indexes. According to the above research, something can be learned: In A-share markets, the higher the discriminant index value is, the less number of shares meeting the requirements is; the same discriminant index value, the stock proportion has difference among plates. Confidence P1, P2 and Lift are extremely related to the GC (General Capital), and Lift is extremely related to the Ind (Industry). In the GEM, confidence P1 of mid-cap is near [0.7,1], Lift is near (1,3), confidence P1 of the manufacturing industry is near [0.7,1].
Sensing Cardiac Electrical Activity With a Cardiac Myocyte Targeted Optogenetic Voltage Indicator

Rationale : Monitoring and controlling cardiac myocyte activity with optogenetic tools offers exciting possibilities for fundamental and translational cardiovascular research. Genetically encoded voltage indicators may be particularly attractive for minimal invasive and repeated assessments of cardiac excitation from the cellular to the whole heart level. Objective : To test the hypothesis that cardiac myocyte-targeted voltage-sensitive fluorescence protein 2.3 (VSFP2.3) can be exploited as optogenetic tool for the monitoring of electrical activity in isolated cardiac myocytes and the whole heart as well as function and maturity in induced pluripotent stem cell (iPSC)-derived cardiac myocytes. Methods and Results : We first generated mice with cardiac myocyte-restricted expression of VSFP2.3 and demonstrated distinct localization of VSFP2.3 at the t-tubulus/junctional sarcoplasmic reticulum microdomain without any signs for associated pathologies (assessed by echocardiography, RNA-sequencing, and patch clamping). Optically recorded VSFP2.3 signals correlated well with membrane voltage measured simultaneously by patch-clamping. The utility of VSFP2.3 for human action potential recordings was confirmed by simulation of immature and mature action potentials in murine VSFP2.3 cardiac myocytes. Optical cardiograms (OCGs) could be monitored in whole hearts ex vivo and minimally invasively in vivo via fiber optics at physiological heart rate (10 Hz) and under pacing-induced arrhythmia. Finally, we reprogrammed tail-tip fibroblasts from transgenic mice and used the VSFP2.3 sensor for benchmarking functional and structural maturation in iPSC-derived cardiac myocytes. Conclusions : We introduce a novel transgenic voltage-sensor model as a new method in cardiovascular research and provide proof-of-concept for its utility in optogenetic sensing of physiological and pathological excitation in mature and immature cardiac myocytes in vitro and in vivo. The purpose of this study was to establish the first cardiac optogenetic voltage sensor mouse model with robust expression and function of VSFP2.3 under the control of the cardiac myocyte specific α -myosin heavy chain ( α MHC) promoter 17 . Analysis at the cellular and whole organ level revealed no transgene toxicity and produced highly reliable optical recordings of cardiac myocyte-specific membrane voltage changes during physiologically and pathologically stimulated contraction cycles. Furthermore, we demonstrate the applicability of VSFP2.3 for the monitoring of cellular function and maturation in iPSC-derived cardiac myocytes. excitation, Semrock) and a dichroic mirror (480 nm). Emitted light was band passed by a 542±27 nm filter (YFP emission, Semrock, Inc) and recorded with a 100x100 pixel CMOS camera (Ultima-L, SciMedia USA Ltd.) at a frame rate of 500 Hz. Recordings were performed during spontaneous sinus rhythm or electrode pacing as indicated. The data were acquired and analyzed by custom-made software programmed in Java and Matlab (Mathworks).
University of Birmingham Pain catastrophizing thoughts explain the link between perceived caregiver responses and pain behaviors of patients with chronic musculoskeletal pain

Purpose: Caregivers’ responses to pain behaviors of patients with chronic pain have an essential role in how patients perceive their pain condition. The current study investigated the mediating role of pain catastrophizing on the link between perceived caregiver responses and patient pain behaviors. Materials and Methods: The sample of this cross-sectional study consisted of 200 patients with chronic pain (mean of age = 44.6; 71.5% were female). Participants responded to measures assessing their perception of their caregiver responses to their pain, their pain catastrophizing thoughts, and their pain behaviors. Results: The mediation analyses showed that perceived distracting responses were negatively related to pain catastrophizing level in patients, which in turn was positively associated with expressing pain behaviors. Besides, perceived caregiver negative responses were positively associated with catastrophizing thoughts, which in turn was positively related to expressing pain behaviors. Conclusion: Patients’ perceptions regarding how their caregiver responds to their pain condition can be related to their thoughts about their pain and how they react to their pain situation. Investigating the external sources that might have an impact on patients’ reactions to their pain, especially when those external sources are caregivers who, in most situations, are with the patients for a prolonged duration, is essential.
The e¡ect of long-term mercury pollution on the soil microbial community

The effect of long-term exposure to mercury on the soil microbial community was investigated in soil from three different sites along a pollution gradient. The amount of total and bioavailable mercury was negatively correlated to the distance from the center of contamination. The size of the bacterial and protozoan populations was reduced in the most contaminated soil, whereas there was no significant difference in fungal biomass measured as chitinase activity. Based on the number of colony morphotypes, moreover, the culturable bacterial population was structurally less diverse and contained a higher proportion of resistant and fast-growing forms. The profiles of amplified 16S rDNA sequences obtained from community DNA by denaturating gradient gel electrophoresis (DGGE) also reflected the altered community structure and decreased diversity along the mercury gradient as expressed in terms of the number and abundance of bands. The functional potential of the microbial population measured as sole carbon source utilization by Ecoplates 0 differed between the soils, but there was no change in the number of substrates utilized. The observed changes in the different soil microbial populations are probably a combination of both direct and indirect effects of the mercury contamination. (cid:223) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Some Common Machine Environment in Scheduling Problems

In this study, we discussed extensively 10 different machine environments commonly encountered in scheduling problems. We incorporated each of these environments into three parameter notation and four parameter notations of representation of scheduling problem. This will assist researchers to have a comprehensive knowledge of each of the machine environment and select the one to explore to provide solution method for a given criteria or set of criteria based on the need of the decision maker.
The Effect of Fiber Supplementation on Chronic Constipation in Adults: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials

ABSTRACT Background Chronic constipation is a prevalent disorder that remains challenging to treat. Studies suggest increasing fiber intake may improve symptoms, although recommendations on the fiber type, dose, and treatment duration are unclear. Objectives We investigated the effects of fiber supplementation on stool output, gut transit time, symptoms, and quality of life in adults with chronic constipation via a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods Studies were identified using electronic databases, backward citation, and hand searches of abstracts. RCTs reporting administration of fiber supplementation in adults with chronic constipation were included. Risks of bias (RoB) was assessed with the Cochrane RoB 2.0 tool. Results were synthesized using risk ratios (RRs), mean differences, or standardized mean differences (SMDs) and 95% CIs using a random-effects model. Results Sixteen RCTs with 1251 participants were included. Overall, 311 of 473 (66%) participants responded to fiber treatment and 134 of 329 (41%) responded to control treatment [RR: 1.48 (95% CI: 1.17, 1.88; P = 0.001); I2 = 57% (P = 0.007)], with psyllium and pectin having significant effects. A higher response to treatment was apparent in fiber groups compared to control groups irrespective of the treatment duration, but only with higher fiber doses (>10 g/d). Fiber increased stool frequency [SMD: 0.72 (95% CI: 0.36, 1.08; P = 0.0001); I2 = 86% (P < 0.00001)]; psyllium and pectin had significant effects, and improvement was apparent only with higher fiber doses and greater treatment durations (≥4 weeks). Fiber improved stool consistency (SMD: 0.32; 95% CI: 0.18, 0.46; P < 0.0001), particularly with higher fiber doses. Flatulence was higher in fiber groups compared to control groups(SMD: 0.80; 95% CI: 0.47, 1.13; P < 0.00001). Conclusions Fiber supplementation is effective at improving constipation. Particularly, psyllium, doses >10 g/d and treatment durations of at least 4 weeks appear optimal, though caution is needed when interpreting the results due to considerable heterogeneity. These findings provide promising evidence on the optimal type and regime of fiber supplementation, which could be used to standardize recommendations to patients. The protocol for this review is registered at PROSPERO as CRD42020191404.
Reduced Differential Transform Method for Partial Differential Equations

Recently differential transform method (DTM) has been used to solve various partial differential equations. In this paper, an alternative approach called the reduced differential transform method (RDTM) is presented to overcome the demerit of complex calculation of differential transform method. Comparing the methodology with some known techniques shows that the present approach is effective and powerful. In addition, three test problems of mathematical physics are discussed to illustrate the effectiveness and the performance of the reduced differential transform method.