AWARD NUMBER: W81XWH-13-1-0175 TITLE: Mesothelioma: Identification of the KeyMolecular Events Triggered by BAP1 PRINCIPAL INVESTIGATOR:

S AND MEETING PRESENTATION: 1. Yang H, Bocchetta M, et al. 13 Euroconference on Apoptosis, 2005, Oct 1-5, Budapest. (Poster) 2. Yang H, Cutrone R, et al. Experimental Biology Conference, 2005, LB385: 84. (Poster) 3. Kroczynska B, Cutrone R, Bocchetta M, Yang H, et al. American Association for Cancer Research Meeting, 2005, April 16-20, Anaheim, California. (Poster) 4. Yang H, Bocchetta M, et al. TNF-a inhibits asbestos induced cytotoxicity via a NF-kB dependent pathway. IMIG meeting in Chicago, Oct 18-22 2006. Lung Cancer, 2006, 54(1): S21. (Oral presentation) 5. Kroczynska B, Cutrone R, Bocchetta M, Yang H, et al. IMIG meeting, Oct 18-22 2006, Chicago. (Poster discussion) 6. Carbone M, Yang H, Pass H. Early Detection of Mesothelioma in the Mesothelioma Villages in Turkey. Gordon Conference in Ventura, CA, January 21-26, 2007. (Oral presentation and poster) 7. Yang H, Bocchetta M et al. TNF-alpha plays a critical role in asbestos-induced oncogenesis. American Association for Cancer Research Meeting, 2007, April, Los Angeles. (Poster) 8. Carbone M, Pass HI, Yang H, et al. Early Detection of Mesothelioma. American Association for Cancer Research Meeting, 2007, April, Los Angeles. (Poster) 9. Kroczynska B, Yang H and Carbone M. Co-carcinogenesis study of wild type SV40 virus and crocidolite asbestos. American Association for Cancer Research Meeting, 2008, April, San Diego. (Poster) 10. Yang H, Carbone M. Onconase inhibits mesothelioma cells invasion induced by TNF-alpha. International Mesothelioma Interest Group (IMIG) meeting, 2008, September, Amsterdam. (Oral presentation) 11. Bocchetta M, Yang H, Eliasz S, et al. The SV40 large T antigen-p53 complexes bind and activate the IGF-1 promoter stimulating cell growth. International Mesothelioma Interest Group (IMIG) meeting, 2008, September, Amsterdam. (Poster discussion) 12. Yang H, Nasu M et al. Asbestos-induced Human Mesothelial Cell Death causes the Release of HMGB1 and Resultant Inflammation. The Third International Damage Associated Molecular Pattern Molecules (DMAPs) and Alarmins Symposium, 2008, September, Pittsburgh. (Poster) 13. Yang H, Nasu M et al. Asbestos-induced HM Death Causes Inflammation. International Society for Biological Therapy of Cancer (iSBc) 23 Annual Meeting, 2008, October, San Diego. (Oral Presentation) 14. Nasu Masaki, Carbone M and Yang H. Studies of mesothelioma cells invasion induced by TNF-alpha and the inhibition effect of Onconase. AACR special meeting “Chemical and Biological Aspects of Inflammation and Cancer”. 2008, October, Oahu. (Poster) 15. Yang H. Mechanism of Asbestos Carcinogenesis: Possible New Targets for Cancer Prevention. Translational Cancer Medicine Symposium, 2009, February, Hawaii. (Oral Presentation) 16. Bocchetta M, Yang H, Carbone M. P53-SV40 Tag complexes have oncogenic activity because they activate the IGF-1 signaling pathway and promote cell growth. American Association for Cancer Research 100 Annual Meeting, 2009, April, Denver, Colorado. (Poster) 17. Carbone M, Yang H. Early Detection of Mesothelioma in Cappadocia. 6 Early Detection Research Network (EDRN) Scientific Workshop, 19 EDRN Steering Committee Meeting, 2009, September, Bethesda. (Oral presentation) 18. Yang H, Pass HI, Carbone M. Role of SMRP and Osteopontin for Early Detection of Human Malignant Mesothelioma. NCI translational Science Meeting, 2009, November, Vienna. (Poster) 19. Rivera Z, Ferrone S, Yang H and Carbone M. Inhibition of in vitro growth of human mesothelioma cells by CSPG4-specific monoclonal antibodies. American Association for Cancer Research 101 Annual Meeting,