Miracle-dz/UniFAR-FTUs huggingface dataset:
EXPERIMENTAL EVALUATION OF ANTIDEPRESSANT ACTIVITY OF PLANT LAVANDULA STOECHAS IN SCOPOLAMINE INDUCED ANIMAL MODELS

Context: Anxiety and depression are common disease. Despite some evidence, it is difficult to confirm Lavandula officinalis antidepressant drug. Objective: The effects of L. Stoechas extract were studied in scopolamine-induced memory impairment, anxiety and depression-like behaviour. Materials and Methods: Male rats were divided into control, scopolamine alone-treated group received scopolamine (0.1mg/kg) intraperitoneally (i.p.), daily and 30 min prior to performing behavioural testing on test day, for 12 continuous days and extract pretreated groups received aerial parts hydro alcoholic extract (i.p.) (200, 400 and 800 mg/kg), 30 min before each scopolamine injection. Memory impairment was assessed by Y-maze task, while, elevated plus maze and forced swimming test were used to measure anxiolytic and antidepressive-like activity. Results: Spontaneous alternation percentage in Y maze is increased by scopolamine (15±0.42), whereas lavender (800 mg/kg) enhanced it more (14.5±0.78). Also, lavender pretreatment in LS(800) showed most climbing activity, LS(400) showed highest swimming, LS(200) showed most immobility among all extracts in Forced swimming test (FST). Discussion and Conclusion: Lavender extracts improved scopolamine-induced memory impairment giving a clue about therapeutic dose of LS extract should be high i.e. LS(800 mg/kg) for efficacious antidepressant activity.
Optimal Treatment of Obesity-Related Hypertension

Background—Current guidelines for the treatment of hypertension do not provide specific recommendations for obese hypertensive patients. To identify an optimal treatment regimen for obese hypertensive patients, we studied the interactions between a drug-based weight loss approach by sibutramine and different antihypertensive drug regimens. Methods and Results—This was a prospective, 16-week double-blind placebo-controlled randomized multicenter study in 171 obese hypertensive patients. After a 2-week run-in period, patients receiving 1 of the 3 antihypertensive combination therapies (felodipine 5 mg/ramipril 5 mg [n 57], verapamil 180 mg/trandolapril 2 mg [n 55], or metoprolol succinate 95 mg/hydrochlorothiazide 12.5 mg [metoprolol/hydrochlorothiazide; n 59]) were assigned randomly to sibutramine (15 mg) or placebo. Sibutramine treatment resulted in a significantly greater decrease in body weight, body mass index, and waist circumference and a significant increase in diastolic blood pressure during 24-hour blood pressure monitoring compared with placebo treatment. Sibutramine-induced weight loss and reduction of visceral obesity were markedly attenuated in the metoprolol/hydrochlorothiazide group compared with the other groups. Consistently, improvement in glucose tolerance and hypertriglyceridemia by sibutramine was abrogated in the cohort treated with metoprolol/ hydrochlorothiazide compared with the other groups. Conclusions—The present study demonstrates for the first time that an antihypertensive combination therapy regimen with angiotensin-converting enzyme inhibitors and calcium channel blockers is more advantageous than a -blocker/diuretic–based regimen in supporting the weight-reducing actions and concomitant metabolic changes induced by sibutramine in obese hypertensive patients. These data may help to develop future comprehensive treatment strategies and guidelines for this high-risk patient population. (Circulation. 2007;115:1991-1998.)
A pr 2 01 3 Blackhole – neutron-star mergers at realistic mass ratios : Equation of state and spin orientation effects

Canadian Institute for Theoretical Astrophysics, Univers ity of Toronto, Toronto, Ontario M5S 3H8, Canada Department of Physics & Astronomy, Washington State Univer sity, Pullman, Washington 99164, USA Center for Radiophysics and Space Research, Cornell Univer sity, Ithaca, New York, 14853, USA Department of Astronomy & Astrophysics, University of Toro nto, Toronto, Ontario, M5S 3H5, Canada Theoretical Astrophysics 350-17, California Institute of Technology, Pasadena, California 91125, USA
O-236 Oral No relationship between chromosome aberrations and vacuole-like structures on human sperm head

The modern day evaluation for infertility in the U.S. includes the evaluation of sperm quality, egg quality, tubal patency and uterine cavity assessment. Uterine cavity assessment can be performed by hysterosalpingogram, sono hysterogram and hysteroscopy. Hystersocopy, combined with 3-D vaginal ultrasound, provides the most accurate assessment of uterine cavity abnormalities that impact fertility. These abnormalities can be found in up to 20% of patients diagnosed with infertility and include endometrial polyps, submucosal myomata, intrauterine scar tissue, and congenitial uterine abnormalities. This presentation will demonstrate the technique and accuracy of office hysteroscopy for our infertility patients and suggest routine use during the evaluation and treatment phase of their therapy. O-248 Oral Laparoscopic procedures to enhance IVF success rates T. Falcone The Cleveland Clinic Foundation, Reproductive Endocrinology A81, Cleveland Ohio, U.S.A. Introduction: The purpose of this review is to evaluate the surgical procedures that will influence the outcome of in vitro fertilization (IVF) and discuss some surgical approaches, including the role of robotic surgery. Material & methods: Appropriate online searches (medline/Cochrane (were carried out to specifically address the question of potential surgical procedures i99 Abstracts of the 25th Annual Meeting of ESHRE, Amsterdam, the Netherlands, 28 June 1 July, 2009 Downloaded from https://academic.oup. com/humrep/article-abstract/24/suppl_1/i96/740682 by guest on 29 July 2018
Evidence for electroweak production of two jets in association with a Z γ pair in pp collisions at the ATLAS detector

Evidence for electroweak production of two jets in association with a Z γ pair in √ s = 13 TeV proton– proton collisions at the Large Hadron Collider is presented. The analysis uses data collected by the ATLAS detector in 2015 and 2016 that corresponds to an integrated luminosity of 36 . 1 fb − 1 . Events that contain a Z boson candidate decaying leptonically into either e + e − or μ + μ − , a photon, and two jets are selected. The electroweak component is measured with observed and expected signiﬁcances of 4 . 1 standard deviations. The ﬁducial cross-section for electroweak production is measured to be σ Z γ jj − EW = 7 . 8 ± 2 . 0 fb, in good agreement with the Standard Model prediction. SCOAP 3 .
Political parties and climate policy: A new approach to measuring parties’ climate policy preferences

This study presents an innovative approach to hand-coding parties’ policy preferences in the relatively new, crosssectoral field of climate change mitigation policy. It applies this approach to party manifestos in six countries, comparing the preferences of parties in Denmark, France, Germany, Ireland, Italy and the United Kingdom over the past two decades. It probes the data for evidence of validity through content validation and convergent/discriminant validation and engages with the debate on position-taking in environmental policy by developing a positional measure that incorporates ‘pro’ and ‘anti’ climate policy preferences. The analysis provides evidence for the validity of the new measures, shows that they are distinct from comparable measures of environmental policy preferences and argues that they are more comprehensive than existing climate policy measures. The new measures strengthen the basis for answering questions that are central to climate politics and to party politics. The approach developed here has important implications for the study of new, complex or cross-cutting policy issues and issues that include both valence and positional aspects.
Advantages and disadvantages of outsourcing

Outsourcing is most commonly known as off shoring. It is a good system for many Thai industries. Yet, outsourcing has both advantages and disadvantages. This research was aimed to investigate major advantages and disadvantages of promoting outsourcing in flow of business and economics of Thailand. By using selective sampling technique, the samples of this study were 20 managers and directors in the selected 20small and medium enterprises in different types of industries of Thailand that have been known for applying outsourcing system. The majority of selected companies located in Bangkok and Bangkok vicinity. The qualitative technique of in-depth interview and small group discussion were utilized with sample groups. The findings revealed that the majority of the respondents agreed that the advantaged included expertise, the ability and time to concentrate on core process, risk-sharing, and cost reduction such as recruitment costs and operating costs. The disadvantages of using outsourcing included risk of exposing confidential data and technology, wrong partners, lack of customer focus, and many hidden costs.
A LocationGuard Approach: An Efficacious Scheme to Alleviate DoS Attacks

: CFS, Farsite, and OceanStore file systems store files on a large collection of untrusted nodes that form an overlay network. They use cryptographic techniques to maintain file confidentiality and integrity from malicious nodes. Unfortunately, cryptographic techniques cannot protect a file holder from a denial-of-service (DoS) attack or a host compromise attack. Hence, most of these distributed file systems are vulnerable to targeted file attacks, wherein a n adversary attempts to attack a small (chosen) set of files by attacking the nodes that host them. This paper presents Location Guard—a location hiding technique for securing overlay file storage systems from targeted file attacks. Location Guard ha s three essential components: 1) location key , consisting of a random bit string (eg .,128 bits) that serves as the key to the location of a file, 2) routing guard, a secure algorithm that protects accesses to a file in the overlay network given its location key such that neither its key nor its location is revealed to an adversary, and 3) a set of location inference guards, which refer to an extensible component of the LocationGuard. Our experimental results quantify the overhead of employing LocationGuard and demonstrate its effectiveness against DoS attacks, host compromise attacks, and various location inference attacks.
CCID_A_331354 1613..1619

1Instituto La Beaute (Private Clinic), Curitiba, PR, Brazil; 2Departamento de Dermatologia da FMB-Unesp, Botucatu, SP, Brazil Background: Microfocused ultrasound with visualization (MFU-V) is a recently developed technology that improves the laxity of the skin due to its capacity of precise focal heating of the dermis and deep layers, consequently inducing neocollagenesis and elastin remodeling. Purpose: This case series aimed to assess the efficacy of MFU-V in improving skin laxity, leading to the slimming of the lower third of the face in women who desired to naturally improve the shape of their faces. Patients and Methods: Four women between 29 and 36 years were submitted to a specific protocol with 4-MHz – 4.5-mm and 7-MHz – 3.0-mm transducers (Ulthera) at the buccinators region in one session, and patients were evaluated after 180 days. GAIS (Global Aesthetic Improvement Scale) was assessed through standardized photographs (D0 vs D180). Results: All subjects perceived the slimming of the face after 180 days, as well as the improvement of skin laxity and contour. The practitioner and all the patients were highly satisfied with the results. The assessment of GAIS (D0 vs D180) resulted in score 3 (very improved) for three participants, and score 2 (improved) for one woman. All the patients classified pain experienced during the procedure as mild to moderate. Conclusion: We reported a technique that uses microfocused ultrasound with visualization leading to the slimming of the lower third of the face. Further systematic studies should be performed to understand the mechanism underneath the results and to maximize its performance.
Microaneurysms (MAs) Localization for Severity Assessment

Diabetic Retinopathy (DR) is a retinal complication that can cause blindness in diabetic patients. The early signs of diabetic retinopathy can be identified by the presence of microaneurysms (MAs) in the retina of the patients. The number of the MAs can indicate the severity of the disease. In this paper, the detection of the MAs using image processing techniques are proposed in order to determine the severity of MAs by counting the number of MAs in the image. In this work, 30 images from MESSIDOR and ImageRet database were utilized and the average accuracy obtained is 99.7%.
The Effect of the Mode Solver on the Optical Fiber Characteristics

The loss and dispersion of optical fiber are essential characteristics that should be identified in fiber optics design as optical transmission lines. To obtain acceptable Dispersion compensated fiber DCF, one way to achieve high negative dispersion is to modify the refractive index definition of DCF. In this paper, using the optifiber software, the zero dispersion wave length (ZDW) conversion is a transformer by changing the standard single-mode fiber S-SMF standard refractive index profile for single-mode fibers, and then promoting a profile designed to reduce dispersion, bending loss and splice loss. Performance analysis is done using two design of fiber profiles using finite difference method analysis. The achieved results, by compared the characteristics of the step-index with two ring profiles in two different designs analysis, it has been found that better results for dispersion and loss done by decreasing the width of the core and cladding region inside the fiber.
: Financial Virtual Assistant

— Getting information about the current and past financial situation of a company is important before investing in this company. Extracting this information from an information system that uses taxonomy recognized by the financial markets using natural language, is a facility for the investor who has no knowledge and no expertise in computer science. The virtual assistance software are alternatives to help people in an area of knowledge. However, it is observed that there is no information system that interacts with the user through natural language to answer questions about financial information of companies, based on data available in electronic financial disclosures. This paper presents a computational system of virtual assistance, named Financial Virtual Assistant (FVA), which recognizes user questions relating to financial situation of companies, through text, or voice, in natural language. This system provides answers based on available information in electronic financial statements represented in eXtensible Business Reporting Language (XBRL) technology. The system's implementation is based on a proposed architecture for specific purpose virtual assistants that uses a Natural Language Processor (NLP) and the domain information services. Details of this architecture, the system’s implementation and the used natural language processing configuration are presented. During testing, the Assistant correctly answered all financial questions about certain companies in a compatible average period with available generic virtual assistants in the market. Besides that, the Assistant could to talk to the user, simulating a conversation between people.
Survey on big data security in various applications

The present era has become a digital world, which has been serving the mankind in each and every sector. Due to this, a lot of varied data is used and stored across the digital world. To handle this tremendous varied data, the concept of big data plays a vital role. Data and big data are two sides of a single coin. Digitization has been made possible along with the growth of data through Big data. This leads to creation of many security concerns in Big Data applications. This paper presents a review on some of the existing security and privacy issues on different big data application domains and triggered some new additional V’s like visualization plus vulnerability, which has been correlated with the security and privacy issues on those domains. This paper also focuses on that application area which has not taken security and privacy issues of big data into consideration. We have also found some new issues that could become possible threats for the protective data in various applications.
Relationship to Potassium and Cycle Length

Marked QT prolongation with induction of polymorphous ventricular tachycardia ('Torsades de Pointes') is a well-described phenomenon during quinidine therapy, frequently occurring at low plasma quinidine concentrations, low serum potassium, and slow heart rates. We have therefore assessed the dose-electrophysiological effects of quinidine as a function of extracellular potassium and cycle length in canine Purkinje fibers, using standard microelectrode techniques. Quinidine (1 MM) prolonged action potential at 90% repolarization, while leaving phase zero upstroke slope (Vm«) unchanged at a cycle length 300-8000 msec; at 10 MM, V,,,,,, depression became evident. Increases in the action potential at 90% repolarization were most marked at long cycle lengths and low extracellular potassium (in contrast to V ^ depression) and were partially reversed by tetrodotoxin (1 M)The relationship between log of cycle length and action potential at 90% repolarization was linear (for cycle length 300-8000 msec) in the absence of quinidine. Quinidine increased the slope of this relationship in a concentration-related fashion, whereas increasing extracellular potassium shifted the curve rightward (without changing slope), regardless of the presence or absence of quinidine. Action potentials were also measured following pauses of 5-60 seconds. In the absence of quinidine, the action potential depolarization returned to its baseline value in a monoexponential fashion (time constant 36.0 ± 4.9 sec, mean ± SE, n = 10). In the presence of 1 JIM quinidine, this return was better fit as a biexponential process (time constants 4.2 ±1.2 and 40.7 ± 6.2 seconds, n = 14). At slow stimulation rates (cycle length greater than 4000 msec) in low extracellular potassium (2.7 mM), quinidine produced early afterdepolarizations in 7/14 (50%) of fibers at 1 MM and 14/18 (78%) at 10 MM. Early afterdepolarizations were eliminated by increasing stimulation rates, raising the extracellular potassium concentration to 5 mM, or adding tetrodotoxin. These data suggest that prolongation by quinidine of action potentials at 90% repolarization is multifactorial, with both a 'tonic' prolonging effect and a prominent frequency-dependent action potential shortening effect. At long cycle lengths and low extracellular potassium, low quinidine concentrations consistently produced early afterdepolarizations. The parallels between this form of triggered activity and clinical arrhythmias induced by quinidine suggest that early afterdepolarizations may play a role in quinidine-induced Torsades de Pointes. (Circ Res 56: 857-867, 1985)
Economic Liberalization And Foreign Direct Investment In Nigeria: A Case Study Of Songhai Integrated Farm System In Enugu State

In today’s capitalist production process, the liberalization of foreign direct investment has gained prominent ground in response to the demand of the global society. To meet up with the expectation, the Nigerian government since 1999, when the country embraced the wave of modern democracy strived to key into the globalization agenda of economic liberalization vis-à-vis foreign direct investment. Thus, the aim of this paper is to explore the impact of economic liberalization on foreign direct investment, as it affects the agarian economy in Nigeria. To achieve this, the theory of economic liberalization was employed for analytical purposes. The data for the study were generated mainly from the secondary source, where the examination of relevant documents and books were engaged. From the appraisal, it was established that economic liberalism which guarantees the removal of necessary obstacles to foreign direct investment, ensure the free flow of capital and investment from one country to another. The Nigerian experience in the agricultural sector as witnessed in this paper demonstrated that foreign direct investment, in the agricultural sector promotes entrepreneurship and job creation. The implication is that economic liberalization in the area of agricultural production enhances macro-economic activities and industrialization and subsequent economic growth and development in a developing economy like Nigeria.
Diagnosis, Management, and Future Control of Cholera

Cholera, caused by Vibrio cholerae, persists in developing countries due to inadequate access to safe water, sanitation, and hygiene. There are approximately 4 million cases and 143,000 deaths each year due to cholera. SUMMARY Cholera, caused by Vibrio cholerae, persists in developing countries due to inadequate access to safe water, sanitation, and hygiene. There are approximately 4 million cases and 143,000 deaths each year due to cholera. The disease is transmitted fecally-orally via contaminated food or water. Severe dehydrating cholera can progress to hypovolemic shock due to the rapid loss of fluids and electrolytes, which requires a rapid infusion of intravenous (i.v.) fluids. The case fatality rate exceeds 50% without proper clinical management but can be less than 1% with prompt rehydration and antibiotics. Oral cholera vaccines (OCVs) serve as a major component of an integrated control package during outbreaks or within zones of endemicity. Water, sanitation, and hygiene (WaSH); health education; and prophylactic antibiotic treatment are additional components of the prevention and control of cholera. The World Health Organization (WHO) and the Global Task Force for Cholera Control (GTFCC) have set an ambitious goal of eliminating cholera by 2030 in high-risk areas.
Characterization of rabbit polyclonal antibody against camel recombinant nanobodies

Abstract Nanobodies (Nbs) are recombinant single-domain fragments derived from camelids’ heavy-chain antibodies (HCAbs). Nanobodies are increasingly used in numerous biotechnological and medical applications because of their high stability, solubility, and yield. However, one major obstacle prohibiting Nb expansion is the affordability of specific detector antibodies for their final revelation. In this work, the production of a specific anti-Nb antibody as a general detector for camel antibodies, conventional cIgG, and HCAb, and their derived Nbs was sought. Thus, a T7 promoter plasmid was constructed and used to highly express six different Nbs that were used in a successful rabbit immunization. Affinity-purified rabbit anti-Nb rIgG was able to detect immobilized or antigen-bound Nbs via enzyme-linked immunosorbent assay, and its performance was comparable to that of a commercial anti-6× His antibody. Its capacities in dosing impure Nbs, detecting Nbs displayed on M13 phages, and revealing denatured Nbs in immune blotting were all proven. As expected, and because of shared epitopes, rabbit anti-Nb cross-reacted with cIgG, HCAbs, and 6× His-tagged proteins, and the percentage of each fraction within anti-Nb rIgG was determined. Anti-Nb is a promising tool for the checkpoints throughout the recombinant Nb technology.