Miracle-dz/UniFAR-FTUs huggingface dataset:
Anti – PD-1 Drug ( Nivolumab ) May Induce Acute and Life-Threatening Pancreatitis in Lung Cancer Patient A Case Report

We acknowledge that the analysis faces several limitations with the retrospective nature, a small cohort size, and lack of a generalized community setting. However, this is the first study that explored the correlates of VTE in patients with pancreatic cancer, which is one of the most thrombogenic cancers and fourth most common cause of cancer-related deaths. The results from our study may be further explored in relation to offering thromboprophylaxis to patients with highly thrombogenic malignancies, which has been a subject of controversy in recent times. In conclusion, our study reports that a highNLR and hypertension at diagnosis are related to an increased incidence of VTE in patients diagnosed with pancreatic cancer. Further prospective trials need to be conducted to explore these results.
Antiproliferative Activity of Berberine from Coscinium fenestratum on NCI-H838 Cell Line

Berberine is the main cytotoxic compound in Coscinium fenestratum. Although, cytotoxic activity of berberine on many cancer cell lines have been studied but effect of berberine on NCI-H838 cell line is still not reported. In the present study, antiproliferative activity and mechanism of berberine isolated from C. fenestratum against NCI-H838 were investigated. NCI-H838 cells were treated with various concentrations of berberine and the cytotoxic activity was evaluated by MTT method. Berberine exhibited cytotoxicity by dose and time dependent manner with the IC 50 values at 24, 48 and 72 h were 111.9 7.0 μM, 92.4 1.2 μM and 68.4 7.9 μM, respectively. Additionally, apoptotic in berberine treated cell was detected by DAPI staining. The associated proteins for apoptosis were examined by western blotting and it was found that berberine downregulated Bcl-2, procaspase 3, 6, 7 and 8 but upregulated caspase 7 by dose dependent manner. Moreover, berberine induced G2/M arrest was determined by the flow cytometric method. Taken together indicated that the potential of antiperiferal activity of berberine mediated through the Bcl-2/caspase-dependent pathway and G2/M cell cycle arrest.
Undergraduate Students' Conceptions of Natural and Anthropogenic Climate Change: A Case Study Approach.

This dissertation shows the evolution of five undergraduate students’ ideas of natural and anthropogenic climate change throughout a lecture hall course on climate change. This research was informed by conceptual change theory and students’ inaccurate ideas of climate change. Subjects represented different levels of climate change understanding at the beginning of the course and were selected based on their scores on a climate change questionnaire. The study was designed to research how students’ ideas changed throughout the course and compare trajectories of lower and higher achieving students. At the beginning, students had different levels of understanding, but as the semester continued, the lower-performing students progressed more than the higher-performing students. At the end of the course, all students described more ideas than they did at the beginning; however some of these ideas were inconsistent with the professors’ instruction. Lower-performing students struggled more than the higher-performing students. Struggles included differentiating climate change and its causes, effects, and consequences from other environmental problems. Students also struggled with the idea that climate change is anthropogenic despite it being natural in the past. In order to understand that climate change is impacted by human forcings in addition to natural forcings, students developed the relationship that climate change is natural and humans are “speeding it up. ” They took time to integrate this relationship into their prior ideas. Three of the students constructed a definition of climate change that was different than the professor’s. Two students defined “climate change” as only the natural aspects of climate change and reserved the anthropogenic changes for the term “global warming”. For a third student, “climate change” included damming rivers, eutrophication, frog mutations, ozone depletion, and overfishing, which are environmental ailments but not climate change.
Large-Eddy Simulation of Flow over Two-Dimensional Obstacles: High Drag States and Mixing

A three-dimensional large-eddy simulation (LES) model was used to examine how stratified flow interacts with bottom obstacles in the coastal ocean. Bottom terrain representing a 2D ridge was modeled using a finitevolume approach with ridge height (4.5 m) and width (;30 m) and water depth (;45 m) appropriate for coastal regions. Temperature and salinity profiles representative of coastal conditions giving constant buoyancy frequency were applied with flow velocities between 0.16 and 0.4 m s 21. Simulations using a free-slip lower boundary yielded flow responses ranging from transition flows with relatively high internal wave pressure drag to supercritical flow with relatively small internal wave drag. Cases with high wave drag exhibited strong lee-wave systems with wavelength of ;100 m and regions of turbulent overturning. Application of bottom drag caused a 5‐10-m-thick bottom boundary layer to form, which greatly reduced the strength of lee-wave systems in the transition cases. A final simulation with bottom drag, but with a much larger obstacle height (16 m) and width (;400 m), produced a stronger lee-wave response, indicating that large obstacle flow is not influenced as much by bottom roughness. Flow characteristics for the larger obstacle were more similar to hydraulic flow, with lee waves that are relatively short in comparison with the obstacle width. The relatively strong effect of bottom roughness on the small obstacle wave drag suggests that small-scale bottom variations may be ignored in internal wave drag parameterizations. However, the more significant wave drag from larger-scale obstacles must still be considered and may be responsible for mixing and momentum transfer at distances far from the obstacle source.
The missing links

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The interaction between monoamine oxidase A (MAOA) and childhood maltreatment as a predictor of personality pathology in females: Emotional reactivity as a potential mediating mechanism

Abstract Research consistently demonstrates that common polymorphic variation in monoamine oxidase A (MAOA) moderates the influence of childhood maltreatment on later antisocial behavior, with growing evidence that the “risk” allele (high vs. low activity) differs for females. However, little is known about how this Gene × Environment interaction functions to increase risk, or if this risk pathway is specific to antisocial behavior. Using a prospectively assessed, longitudinal sample of females (n = 2,004), we examined whether changes in emotional reactivity (ER) during adolescence mediated associations between this Gene × Environment and antisocial personality disorder in early adulthood. In addition, we assessed whether this putative risk pathway also conferred risk for borderline personality disorder, a related disorder characterized by high ER. While direct associations between early maltreatment and later personality pathology did not vary by genotype, there was a significant difference in the indirect path via ER during adolescence. Consistent with hypotheses, females with high-activity MAOA genotype who experienced early maltreatment had greater increases in ER during adolescence, and higher levels of ER predicted both antisocial personality disorder and borderline personality disorder symptom severity. Taken together, findings suggest that the interaction between MAOA and early maltreatment places women at risk for a broader range of personality pathology via effects on ER.
Cytoskeletal Social Networking in the Growth Cone: How +TIPs Mediate MicrotubuleActin CrossLinking to Drive Axon Outgrowth and Guidance

The growth cone is a unique structure capable of guiding axons to their proper destinations. Within the growth cone, extracellular guidance cues are interpreted and then transduced into physical changes in the actin filament (F-actin) and microtubule cytoskeletons, providing direction and movement. While both cytoskeletal networks individually possess important growth cone-specific functions, recent data over the past several years point towards a more cooperative role between the two systems. Facilitating this interaction between Factin and microtubules, microtubule plus-end tracking proteins (1TIPs) have been shown to link the two cytoskeletons together. Evidence suggests that many 1TIPs can couple microtubules to F-actin dynamics, supporting both microtubule advance and retraction in the growth cone periphery. In addition, growing in vitro and in vivo data support a secondary role for 1TIPs in which they may participate as F-actin nucleators, thus directly influencing F-actin dynamics and organization. This review focuses on how 1TIPs may link F-actin and microtubules together in the growth cone, and how these interactions may influence axon guidance. VC 2016 Wiley Periodicals, Inc.
Association of gas cooking with children's respiratory health: results from GINIplus and LISAplus birth cohort studies.

UNLABELLED Previous studies have found inconsistent results on the association between asthma in children and gas cooking emissions. We aimed to assess the effects of the long-term exposure to gas cooking on the onset of asthma and respiratory symptoms, focusing on wheezing, in children from two German birth cohorts: LISAplus and GINIplus. A total of 5078 children were followed until the age of 10 years. Asthma, wheezing, gas cooking, and exposure to other indoor factors were assessed through parental reported questionnaires administered periodically. Logistic and multinomial regressions adjusting for potential confounders were performed. The prevalence of asthma and persistent wheezing was higher among children exposed to gas cooking but the results were not statistically significant. Exposure to gas cooking was positively associated (P-value < 0.05) with exposure to other indoor factors (dampness, environmental tobacco smoke, and pets). Our results did not show a statistically significant association between the exposure to gas cooking and children's respiratory health. PRACTICAL IMPLICATIONS These analyses are consistent with the assumption of no effect of the exposure to low doses of nitrogen dioxide. The strong positive associations found between gas cooking and other indoor factors highlight the importance of considering other indoor factors when assessing health effects of gas cooking. Low-dose exposure to indoor nitrogen dioxide through gas cooking might not contribute to increase the risk of asthma and respiratory symptoms in children.
Individual, programmatic and systemic indicators of the quality of mental health care using a large health administrative database: an avenue for preventing suicide mortality

Paper: Rahme, E. , Thibodeau, L. , Lachaud, J., Pelletier, É. , Rochette, L. , John, A. , Reneflot, A. , Lloyd, K. & Lesage, A. (2018). Status report Individual, programmatic and systemic indicators of the quality of mental health care using a large health administrative database: an avenue for preventing suicide mortality. Health Promotion and Chronic Disease Prevention in Canada, 38(7/8), 295-304. http://dx.doi. org/10.24095/hpcdp.38. 7/8.04
Application of dynamic parametric sensitivity analysis for identifying contaminant sources in a watershed.

Lakes of the Fulton Creek watershed in Northern Saskatchewan, Canada, possess constituents associated with uranium mining. Although mining activity ceased over 24 years ago and site decommissioning was largely completed in 1985, the discharge from this former tailings management watershed continues to have elevated levels of three specific constituents, namely dissolved radium-226, selenium and uranium, as well as total dissolved solids (TDS). The objective of the current study was to identify and rank the sources of constituents in the watershed. Constituent dispersion modelling was carried out employing a proprietary computer code called LAKEVIEW (developed by SENES Consultants Limited). Using the Metropolis-Hastings algorithm of a Markov chain computational procedure, parameter calibration was performed at two locations in the watershed with 25 years of more or less regular water quality and occasional sediment monitoring data. The calibrated model captured the time dependent trends for all variables. Employing the Metropolis-Hastings parameter sampler, dynamic parametric (source) sensitivity analysis was carried out for a 300-year period. The sensitivity responses showed strong temporal variability. Therefore, the normalized gradient sensitivity values were integrated and averaged over time for use as the measure of constituent source loads. Sediments in two lakes were shown to be both the current and future principal sources of all constituents. An adjacent surface tailings area was identified as a relatively minor contributor of all constituents but uranium.
Exploiting noise, nonlinearity, and feedback to differentially control multiple synthetic cells with a single optogenetic input

Abstract Synthetic biology seeks to develop modular bio-circuits that combine to produce complex, controllable behaviors. These designs are often subject to noisy fluctuations and uncertainties, and most modern synthetic biology design processes have focused to create robust components to mitigate the noise of gene expression and reduce the heterogeneity of single-cell responses. However, deeper understanding of noise can achieve control goals that would otherwise be impossible. We explore how an “Optogenetic Maxwell Demon” could selectively amplify noise to control multiple cells using single-input-multiple-output (SIMO) feedback. Using data-constrained stochastic model simulations and theory, we show how an appropriately selected stochastic SIMO controller can drive multiple different cells to different user-specified configurations irrespective of initial condition. We explore how controllability depends on cells’ regulatory structures, the amount of information available to the controller, and the accuracy of the model used. Our results suggest that gene regulation noise, when combined with optogenetic feedback and non-linear biochemical auto-regulation, can achieve synergy to enable precise control of complex stochastic processes.Synthetic biology seeks to develop modular bio-circuits that combine to produce complex, controllable behaviors. These designs are often subject to noisy fluctuations and uncertainties, and most modern synthetic biology design processes have focused to create robust components to mitigate the noise of gene expression and reduce the heterogeneity of single-cell responses. However, deeper understanding of noise can achieve control goals that would otherwise be impossible. We explore how an “Optogenetic Maxwell Demon” could selectively amplify noise to control multiple cells using single-input-multiple-output (SIMO) feedback. Using data-constrained stochastic model simulations and theory, we show how an appropriately selected stochastic SIMO controller can drive multiple different cells to different user-specified configurations irrespective of initial condition. We explore how controllability depends on cells’ regulatory structures, the amount of information available to the controller, and the accuracy of the model used. Our results suggest that gene regulation noise, when combined with optogenetic feedback and non-linear biochemical auto-regulation, can achieve synergy to enable precise control of complex stochastic processes.
Modeling poroelastic effect on borehole stability for under-balanced and over-balanced drilling conditions

Since rock formations are always saturated by fluids, the coupled poroelastic models were developed to conduct wellbore stability analysis. The analysis based on this theory allows us to consider phenomena such as well communication with rock formation, change of pore pressure profile, pore pressure dissipation, etc. This article presents the analytical solution of one coupled poroelastic model and then departs to consider two common drilling scenarios, which are under-balanced drilling (UBD) and over-balanced drilling (OBD). Obtained results show that the phenomena of time-dependent delayed failure and failure initiation taking place not only at the wellbore wall but also inside the formation can be predicted by virtue of the coupled model. Moreover, these two phenomena are different for the two drilling scenarios mentioned above. Regarding the (UBD), the borehole stability status will get enhanced with time due to the poroelastic effect in the formation. On the contrary, the borehole stability status will get worse, and time-delayed failure may happen for the OBD.
Transport of Surface Freshwater from the Equatorial to the Subtropical North Atlantic Ocean

AbstractThe transport of low-salinity water northward in the tropical and subtropical North Atlantic Ocean influences upper-ocean stratification, vertical mixing, and sea surface temperature (SST). In this study, satellite and in situ observations are used to trace low-salinity water northward from its source in the equatorial Atlantic and to examine its modification through air–sea fluxes and vertical mixing. In contrast to gridded climatologies, which depict a gradual northward dispersal of surface freshwater from the equatorial Atlantic, satellite observations and direct measurements from four moorings in the central tropical North Atlantic show a distinct band of surface freshwater moving northward from the equatorial Atlantic during boreal fall through spring, with drops in sea surface salinity (SSS) of 0.5–2.5 psu in the span of one to two weeks as the low SSS front passes. The ultimate low-latitude source of the low SSS water is found to be primarily Amazon River discharge west of 40°W and rainfall.
PHYSICOCHEMICAL AND ENGINEERING BEHAVIOR OF CEMENT TREATED CLAYS

This paper examines the relationship between the microstructure and engineering properties of cement-treated marine clay. The microstructure was investigated using x-ray diffraction, scanning electron microscopy, pH measurement, mercury intrusion porosimetry, and laser diffractometric measurement of the particle size distribution. The engineering properties that were measured include the water content, void ratio, Atterberg limit, permeability, and unconfined compressive strength. The results indicate that the multitude of changes in the properties and behavior of cement-treated marine clay can be explained by interaction of four underlying microstructural mechanisms. These mechanisms are the production of hydrated lime by the hydration reaction which causes flocculation of the illite clay particles, preferential attack of the calcium ions on kaolinite rather than on illite in the pozzolanic reaction, surface deposition and shallow infilling by cementitious products on clay clusters, as well as the presence of water trapped within the clay clusters.
Hispanic parental perceptions about telemedicine: Potential targets for interventions to improve access to care

Introduction One benefit of the COVID-19 pandemic has been the growth and expansion of telemedicine capabilities with the potential to improve access to healthcare in the face of social isolation mandates. However, adoption of telemedicine has been suboptimal in the Hispanic community and data has been sparse regarding Hispanic experiences with and opinions regarding telemedicine. Methods To gather feedback regarding telemedicine and to identify potential barriers to telemedicine use in the Hispanic community, we performed semi-structured interviews about telemedicine experiences among both Hispanic and non-Hispanic parents who had performed both in-person and at least one telemedicine visit for their child at our institution. Mixed methods were utilized to analyze interview responses. Results and Discussion Overall, Hispanic parents overwhelmingly preferred in-person to telemedicine encounters as compared with non-Hispanic parents. Targets were identified to improve the use of telemedicine and to potentially improve access to healthcare in the Hispanic community.
Psychological interventions for acute pediatric pain

Introduction 308 Significance of the problem 309 Psychological influences on children’s acute pain 309 Developmental considerations 311 Ethnic and cultural considerations 311 Management 312 Preparation 312 Distraction 313 Relaxation 313 Breathing techniques 314 Hypnosis 315 Guided imagery 316 Combined cognitive and behavioral interventions 317 Parental involvement in acute pain management 318 Conclusions 319 References 319
PET/MR Imaging: Technical Aspects and Potential Clinical

26 radiology.rsna. org Radiology: Volume 267: Number 1—April 2013 1 From the Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104-4283 (D.A.T., B.S., J.K.U., A.A.); Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, Switzerland (H.Z.); Geneva Neuroscience Center, Geneva University, Geneva, Switzerland (H.Z.); Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (H.Z.); Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands (T.C.K.); and Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon, South Korea (Z.H.C.). Received June 8, 2012; revision requested July 27; revision received December 8; accepted December 27; final version accepted December 28. Supported by the Swiss National Science Foundation under grants SNSF 31003A-135576, 33CM30-124114, Geneva Cancer League, and the Indo-Swiss Joint Research Programme ISJRP 138866. Address correspondence to D.A. T. (e-mail: Drew .Torigian@uphs.upenn.edu).
Low-fat dietary pattern and lipoprotein risk factors: the Women's Health Initiative Dietary Modification Trial.

BACKGROUND The Women's Health Initiative Dietary Modification Trial tested the effects on chronic disease of a dietary pattern lower in fat and higher in vegetables, fruit, and grains. OBJECTIVE The objective was to evaluate the effects of dietary carbohydrate changes on lipids and lipoprotein composition. DESIGN Postmenopausal women were randomly assigned to an intervention or a comparison group for a mean of 8.1 y. Lipoprotein analyses and subclasses were based on subsamples of 2730 and 209 participants, respectively. RESULTS At year 6, the total reported fat intake was 7.8% lower and carbohydrate intake was 7.6% higher in the intervention group than in the comparison group. Triglyceride change between groups differed by 2.3, 3.8, and -0.8 mg/dL at 1, 3, and 6 y, respectively, and HDL-cholesterol change differed by -1.6, -0.7, and -1.0 mg/dL at 1, 3, and 6 y, respectively. Changes did not differ by age, ethnicity, or obesity. In diabetic intervention women who were white, the triglyceride difference between the intervention and comparison groups was 33.8 mg/dL, whereas in black women with diabetes (n = 50 in the intervention group; n = 83 in the comparison group), the triglyceride difference was 6.4 mg/dL (P for 3-factor interaction = 0.049). No significant changes were observed in apolipoprotein or lipoprotein particles. Reductions in LDL cholesterol varied by quartile of reported lowering of saturated or trans fat. CONCLUSIONS The replacement of 7-8% of fat intake with complex carbohydrates over 6 y was not associated with clinically adverse effects on triglycerides, HDL cholesterol, or lipoprotein subclasses. Diabetic white women with higher triglyceride concentrations may have greater increases in triglycerides.