Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of Ameliorative Properties of Methanol Extract of Pleurotus ostreatus Cultivated with Extract of Allium cepa on Oxidative Stress Markers of CCl4 Induced Hepatotoxicity in Wistar Rats

This study was designed to assess the ameliorative properties of methanol extract of Pleurotus ostreatus cultivated with extract of Allium cepa on oxidative stress markers of CCl4 induced hepatotoxicity in wistar albino rats. Seventy wistar albino rats were used for the study and were grouped into 7 of ten rats in each. Groups 2-7 received a dose of 0.3ml/kg body weight (b.w) of CCl4 in 1:1 olive oil via intraperitoneally twice a week. Those in group 1 received only normal rat chow without CCl4. Groups 3, 4, 5 and 7 orally received a dose of 100mg/kg b.w, 200mg/kg b.w, 300mg/kg b.w and 200mg/kg b.w of the methanol extract respectively. Group 6 and 7 orally received a dose of 5.2mg/kg b.w of livolin and group 7 alone orally received a dose of 50mg/kg b.w of vitamin C. These treatments were administered for 30 days and the following biochemical markers; Thiobarbituric Acid Reactive Substances (TBARS), Catalase (CAT) and Superoxide Dismutase (SOD) were estimated on day 10, 20 and 30 after treatment. Result showed that the values of TBARS significantly increased at p<0.05 on day 10, 20 and 30 in group 2 compared to group 1 while the values of CAT and SOD significantly decreased at p<0.05 on day 10, 20 and 30 in group 2 compared to group 1. The values of TBARS significantly decreased at p<0.05 on day 10, 20 and 30 in groups 3,4,5, 6 and 7 compared to group 2 while the values of CAT and SOD significantly increased at p<0.05 on day 10, 20 and 30 in groups 3,4,5,6 and 7 compared to group 2. These findings suggest that methanol fruiting body extract of Pleurotus ostreatus cultivated with extract of Allium cepa scavenged the free radicals responsible for oxidative stress initiated by CCl4 and subsequently ameliorated and substantially reversed the toxic effect of the tissue specific toxicant. © 2016 Elixir All rights reserved. Elixir Bio Sci. 96 (2016) 41595-41599 Bio Sciences Available online at www.elixirpublishers. com (Elixir International Journal) Ogbeifun, H. E. et al./ Elixir Bio Sci. 96 (2016) 41595-41599 41596 weighed and distributed into seven groups. These animals were put in plastic cages and left under suitable laboratory conditions for two weeks for them to acclimatize to the new environment. The cages were cleaned daily. The animals were fed with commercial growers mash product of Top feeds Ltd., Sapele, Nigeria and water served ad libitum. The animals’ body weights were recorded before commencement of treatment.
Human-inspired motion primitives for a safe and effective HRI and autonomous manipulation*

—Recent advancements in robotics are pushing toward a more strict interaction between machines and their surrounding environment, including humans, in the general framework of co-botics , in both industrial and assistive applications. This comes with the need of guaranteeing i) the acceptability of the technology and ii) the users’ safety. One of the key characteristics that a co-bot should have to satisfy these requirements is to behave as a human would, especially for what concerns the predictability of the robot movements. The intent of our work is to develop a framework for the generation of human-inspired movements for a generic redundant manipulator that works in an unstructured environment. This manuscript reports on recent advancements of our contribution to this line of research, with a special focus on the identiﬁcation of a basis of motion primitives, which can be used as key ingredients for the planning of human-like motions. Then, we discuss how the feed-forward implementation of these human-like motions can be integrated with a tactile-based feedback policy, when a purposeful interaction with an object happens. These results could open also interesting perspectives for autonomous robotic manipulation.
Characteristic Abnormalities In Serum Biochemistry In Patients With Breast Cancer

Introduction: Free radicals play an effective role in the pathogenesis of different pathological diseases together with cancer which is the second leading cause of cancer death in women worldwide and the main aim of this study was to estimate the of Thrombospondin (TSP-1),TAS, malondialdehyde (MDA) , Paraoxonase(PON1), and arylesterase (ARE) ,selenium (SE), and G6PD as antioxidant capability in breast cancer patients and to compare with apparently healthy individuals. Methods: A total of 150 subjects were recruited which included 75 patients (age range 25 to 45 years) with BC attending the Kirkuk Teaching Hospital ( Kirkuk province), were enrolled in this study, in a period from 15 December 2019 to 20 March 2020.and 75 controls (age and sex matched). The analysis of covariance was used to identify any significant differences and statistical significance was set
Advance Control Technique for Power Management and Synchronized Operation of Hybrid Micro-grid System

The Hybrid micro-grid system is nothing but combined system including distributed generation power sources and main grid. These both operate in coordination and synchronization . The main problem in such micro grid structure is to manage power flow among all sources distributed in AC and DC grid also complex issues like sag, swell, interrupt, voltage instability etc occurs amongst which voltage stability is an important issue which may result in islanding. This paper presents model of Hybrid Grid system with efficient and reliable control scheme for power flow balance between AC and DC grids which maintain both DC and AC voltage. It is also proposing an efficient AC/DC micro grid structure connected through multi bidirectional converters . The voltage will be stabilized with the help of coordination control algorithms. The control signals of DC back to back converter can be generated by sensing supply grid parameters and comparing it with reference values. The aim of proposed system is to optimum use of the micro sources, stable control strategies in secondary level and advance control technique for synchronized operation. This can be done by simulating the control system of hybrid micro grid system and developing its prototype and results are verified.
Therapeutic inhibition of FcgammaRIIb signaling targets leukemic stem cells in chronic myeloid leukemia

Despite the successes achieved with molecular targeted inhibition of the oncogenic driver Bcr-Abl in chronic myeloid leukemia (CML), the majority of patients still require lifelong tyrosine kinase inhibitor (TKI) therapy. This is primarily caused by resisting leukemic stem cells (LSCs), which prevent achievement of treatment-free remission in all patients. Here we describe the ITIM (immunoreceptor tyrosine-based inhibition motif)-containing Fc gamma receptor IIb (FcγRIIb, CD32b) for being critical in LSC resistance and show that targeting FcγRIIb downstream signaling, by using a Food and Drug Administration-approved BTK inhibitor, provides a successful therapeutic approach. First, we identified FcγRIIb upregulation in primary CML stem cells. FcγRIIb depletion caused reduced serial re-plaiting efficiency and cell proliferation in malignant cells. FcγRIIb targeting in both a transgenic and retroviral CML mouse model provided in vivo evidence for successful LSC reduction. Subsequently, we identified BTK as a main downstream mediator and targeting the Bcr-AblFcγRIIb-BTK axis in primary CML CD34 cells using ibrutinib, in combination with standard TKI therapy, significantly increased apoptosis in quiescent CML stem cells thereby contributing to the eradication of LSCs. As a potential curative therapeutic approach, we therefore suggest combining Bcr-Abl TKI therapy along with BTK inhibition.
Impact of gameplay vs. reading on mental models of social-ecological systems: a fuzzy cognitive mapping approach

Climate change is a highly complex social-ecological problem characterized by system-type dynamics that are important to communicate in a variety of settings, ranging from formal education to decision makers to informal education of the general public. Educational games are one approach that may enhance systems thinking skills. This study used a randomized controlled experiment to compare the impact on the mental models of participants of an educational card game vs. an illustrated article about the Arctic social-ecological system. A total of 41 participants (game: n = 20; reading: n = 21) created preand post-intervention mental models of the system, based on a "fuzzy cognitive mapping" approach. Maps were analyzed using network statistics. Both reading the article and playing the game resulted in measurable increases in systems understanding. The group reading the article perceived a more complex system after the intervention, with overall learning gains approximately twice those of the game players. However, game players demonstrated similar learning gains as article readers regarding the climate system, actions both causing environmental problems and protecting the Arctic, as well as the importance of the baseand mid-levels of the food chain. These findings contribute to the growing evidence showing that games are important resources to include as strategies for building capacity to understand and steward sustainable social-ecological systems, in both formal and informal education.
Characterization of Asphalt Binder Containing Microcapsules Mikrokapsül içeren asfalt malzemelerin özelliklerinin Araştırılması

Asphalt pavements are exposed to traffic loading and adverse environmental effects such as rain and oxidation which result in decreasing their relaxation capabilities and the initiation of cracks. Recent research highlights the importance of developing long life pavements. One of the possible ways is to utilize innovative maintenance techniques such as self-healing technologies in order to reverse the aging process in asphalt binder. So as to achieve this goal, self-healing microcapsules seems to be an effective way to autonomously repair the micro-cracks, restore original mechanical properties, then further slow fatigue cracks growth and increase the fatigue life of the pavement. In this study urea formaldehyde (UF) self-healing microcapsule were prepared by in-situ polymerization method. Following the characterization of microcapsules, different amount of microcapsules (6, 8, 9 ,10, 11 and 12%) were added into bitumen. Rheological properties of the samples have been determined by means of Dynamic Shear Rheometer. Ductility test was also employed to characterize the mechanical properties of the bitumen samples. Based on results the produced microcapsules can endure high temperatures, which indicate that these microcapsules can resist the thermal influence of bitumen in application. Besides, bitumen samples involving microcapsules exhibit satisfactory results in terms of complex modulus (G*) and bitumen recovery tests. The recovery value of the modulus increased first and then decreased with the amount of microcapsules. Microcapsules containing rejuvenator will be a promising product to realize the smart pavements.
BTT_A_310312 199..204

1Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; 3Institute of Biotechnology, College of Natural Science, University of Gondar, Gondar, Ethiopia Abstract: Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins are referred to as CRISPR-Cas9. Bacteria and archaea have an adaptive (acquired) immune system. As a result, developing the best single regulated RNA and Cas9 endonuclease proteins and implementing the method in clinical practice would aid in the treatment of diseases of various origins, including lung cancers. This seminar aims to provide an overview of CRISPR-Cas9 technology, as well as current and potential applications and perspectives for the method, as well as its mechanism of action in lung cancer therapy. This technology can be used to treat lung cancer in two different ways. The first approach involves creating single directed RNA and Cas9 proteins and then distributing them to cancer cells using suitable methods. Single directed RNA looks directly at the lung’s mutated epidermal growth factor receptor and makes a complementary match, which is then cleaved with Cas9 protein, slowing cancer progression. The second method is to manipulate the expression of ligand-receptors on immune lymphocytic cells. For example, if the CRISPR-Cas9 system disables the expression of cancer receptors on lymphocytes, it decreases the contact between the tumor cell and its ligand-receptor, thus slowing cancer progression.
EFFICACY AND SAFETY OF THE OSCILLATORY POSITIVE PRESSURE BREATHING CIRCUIT ON AIRWAY CLEARANCE IN CRITICALLY ILL PATIENTS: A RANDOMIZED CONTROLLED TRIAL

Secretion clearance in patients with chest complication requires a specialized technique of chest physical therapy program. However, some treatment techniques still contain limitations to be used in critically ill patients with intubation. Therefore, present study aimed to 1) develop an oscillatory positive pressure breathing (OPPB) circuit and 2) study the efficacy and safety of the OPPB circuit for secretion clearance in critically ill patients with intubation. This study is an experimental research conducted in 32 samples, randomized into the experimental group and the control group, 16 samples per group. The experimental group received the OPPB circuit whereas the control group received the chest physical therapy program. Both groups were evaluated for hemodynamic and ventilatory functions responsibility and sputum content in pre-, during, and post-intervention. Results: The experiment found that 1) physical properties of the OPPB circuit at resistance of 3 CmH2 with external positive pressure with self-inflating 1000 ml could generate positive pressure of 18.89 mmHg on average and oscillation of 13.6 Hz on average in a normal frequency for cilia beat with secretion clearance efficacy. 2) The OPPB circuit could clear secretion efficiently and was safe to use with critically ill patients with intubation. The results found that the experimental group had significantly better clearance efficacy than the control group (OPPB, 3.45 (0.91) grams, p < 0.001; CPT, 1.56 (0.61) grams, p < 0.001); and was safe to use with patients. It was found that hemodynamic and ventilatory functions responsibility in both groups changed under the normal criteria in post-intervention.
HARD-PART COUNTING FOR IDENTIFICATION OF MARINE ORNAMENTAL FISH SPECIES

Together with the Philippines, Indonesia is the biggest exporter of marine ornamental fishes for the aquarium trade. However, there was no data in place on the number and species involved in the trade. Species diversity and comparable characters among species within genera have made it difficult to identify up to species level. This study aimed to use internal hard part and fin spines-rays counting as complementary data for fish identification. In order not to impair specimens, staining and clearing procedures were implemented to the specimens. Specimens of reef-ornamental fishes for aquarium trade were collected from Bangsring Banyuwangi and Sumber Kima Singaraja Bali. Following photograph, coding and identification, all viscera and internal organs were taken out from each specimen. Bone staining and clearing was held based on alcianblue acetic acid bone coloring, continued with trypsin and alizarin red soaking for 24-h and finally cleared with mixed solution of 0.5% KOH and glycerin for a period of 1-7 days. With the help of a standard photograph, vertebral column, fin-spines and rays were counted to confirm the species. The staining procedure was subject to trial and error but finally succeeded. Vertebral column, fin-spines, and rays from all 50 specimens were counted, confirming the species. This hard-part identification process resulted in 21 nominal (predicted) species. The technique can be applied to small-size and compressed forms of fish bodyshape.
WHISTLEBLOWING ON TAX FRAUD-THE ROLE OF MONETARY INCENTIVES AND SOCIAL DISCRIMINATION

Revenue from tax has become the greatest income for Indonesia government, yet taxpayer’s compliance seems underperformed. The tax authority needs to find an alternative way to increase the revenue and suppress the tax fraud activities among payers. Rather than heavily depends on tax monitoring by fiscus, optimization of whistleblowing system is more effective to detect such acts. In this research, we try to investigate the separate and joint influence of monetary incentives and social discrimination towards whistleblowers on the level of tax fraud reporting intentions. An experiment to 48 participants concludes that monetary incentives make significant increases in reported fraud between tax regime without incentives to whistleblowing and tax regime with incentives. On the contrary, social discrimination in which participants received from other colleagues doesn’t make many differences in fraud reporting. We also investigate and find that the level of tax evasion before and after the incentives policy applied is not different, and the level of reporting from the person that experience loses from the fraudulent accounting (caused by the act of tax evader), significantly higher than others that didn’t suffer directly from it. Overall, the regression model built from both incentives and social discrimination variables doesn’t explain the behavior of tax fraud reporting fromwhistleblowers.
Effect of Auditor Ethics and Audit Tenure on Auditor Ability to Detect Creative Accounting Practices

The purpose of this study is to determine the effect of auditor ethics and audit tenure on auditors' ability to detect creative accounting practices. The study is conducted on auditors who work at the Bali Province Public Accountant Firm which is registered at IAPI 2020. The sample selection method uses purposive sampling technique. The number of samples in the study were 60 people. The analysis technique used is Multiple Linear Regression Analysis. The results show that auditor ethics has a significant negative effect on the ability of auditors to detect creative accounting practices, which indicates that when an auditor detects creative accounting practices in financial statements, the auditor chooses to override ethics and thus ignores actual findings. Meanwhile, audit tenure has a significant positive effect on the ability of auditors to detect creative accounting practices, which indicates that the longer the audit tenure or the longer the audit engagement period, the auditor's ability to detect creative accounting practices in the financial statements will increase.
An Overview of Two Fast Bit-Vector Approximate String-Matching Algorithms

The intent of the article is to give a brief overview and a rough comparison of two well-known bit-parallel algorithms for fast approximate string matching. The first one was described by Gene Myers in article [2] and is a bit-parallel version of the basic algorithm based on dynamic programming. The second one is an enhanced “Shift-Or” type algorithm by Sun Wu and Udi Manber [3]. For sake of simplicity, only the most basic versions of the algorithms will be considered here. Considering the existence of great articles [1], [2] and [3], the whole idea of this work is pretty senseless, therefore it was mostly done only for my own fun and satisfaction.
A QUANTITATIVE INTRA ANALYSIS OF ROUTING PROTOCOLS IN MOBILE AD HOC NETWORKS

Mobile Ad Hoc Network (MANET) is a wireless network with less infrastructure, fixed topology, multi-hop and bandwidth restrictions. A quantitative intra analysis of routing protocols in MANET by efficient routing will result in the use of bandwidth and efficient transmission of data with minimum hop numbers. An effective routing strategy using a broadcast network, established by the current minimum cost spanning tree, is also unable to provide the shortest route for all nodes and also has problems with data transmission performance.We have used NS-2 in this paper for simulation. We have calculated and compared our results by using various routing protocols and have been able to calculate performance throughput, average end delay, PDR, and residual energy nodes using the Random Mobility model. The simulation results showed that in terms of its efficiency, the AODV routing protocol was more effective than other routing protocols.
Climbing and Walking Robots and the Support

In recent years, a number of deep reinforcement learning (DRL) algorithms have emerged that promise to automate the development of locomotion controllers and map sensory observations to low-level actions. However, legged locomotion still is a challenging task for DRL algorithms, especially when slope handling is required. As a result, a framework using commonly used tools (ROS, Gazebo, etc.) and specific slope handling scenarios would enable the evaluation of recent DRL algorithms in order to choose the appropriate algorithm for a given task. In this work, an evaluation framework is proposed that combines DRL with trajectory planning at toe level aiming at reducing training time and facilitate decision-making in slope-handling cases. The proposed evaluation scheme is extensively tested in a Gazebo environment and valuable results are produced using three state-of-the-art DRL algorithms.
Research Article: Molecular genetic divergence of five genera of cypriniform fish in Iran assessed by DNA barcoding

The present study represents a comprehensive molecular assessment of some family of freshwater fishes in Iran. We analyzed cytochrome oxidase I (COI) sequences for five genus of cypriniform fishes from Iran. The present investigation provides data on genetic structure of some species of Nemachilidae including Paraschistura bampurensis, Oxynoemacheilus kiabii and Turcinemacheilus saadii and Leuciscine cyprinids Alburnoides bipunctatus and Alburnus alburnus from inland waters of Iran. The DNA sequences of the mitochondrial COI gene in all fishes were amplified, and the resulting sequences were compared to entries in GenBank using the Basic Local Alignment Search Tool for nucleotide data. Individuals were assigned to groups using COI gene sequence divergence analysis which was determined using Kimura 2parameter distances. Results revealed two major clusters which were inconsistent characterized by mediocre genetic divergence (mean 0.8%). The sequences of P. bampurensis showed that specimens collected from four rivers (Beshar, Khersan, Shapour and Fahlian Rivers, southwest of Iran), with 1.89% for Nemacheilian loaches and 0.8% for two Leuciscine cyprinids within-species Kimura two parameters distance, shared haplotype in Neighbor-joining (NJ) tree. Some clusters showed haplotype sharing, or low levels of divergence between species, hindering reliable identification. We discussed the importance of further DNA barcode studies for native and invasive cyprinid species and subsequent submission to GenBank databases for more reliable species match and inference.