Miracle-dz/UniFAR-FTUs huggingface dataset:
OPTH_A_270243 3599..3610

Clinical Research Department, Retina Macula Institute, Torrance, CA, USA Purpose: To compare monthly versus pro re nata (PRN) ranibizumab injections in the treatment of exudative macular degeneration (AMD) while assessing the utility of microperimetry (MP) and multifocal electroretinography (mfERG) testing when monitoring response to treatment. Methods: A randomized exploratory trial comparing the efficacy of monthly versus PRN dosing of ranibizumab (0.5 mg or 2.0 mg) for patients with exudative AMD over 12 months. High-resolution optical coherence tomography (HR-OCT) studies were used to guide PRN treatment and any cystic spaces or subretinal fluid prompted retreatment. Macular function was assessed using mean sensitivity on MP and N1-P1 response density on mfERG. Bestcorrected visual acuity (BCVA) was measured with Early Treatment Diabetic Retinopathy Study (ETDRS) letters and anatomic response assessed with central foveal thickness (CFT) using HR-OCT studies. Results: The 12-month study was completed by 43 patients in the PRN cohort and 33 patients in the monthly cohort. Mean BCVA improved by 6.0 ± 1.3 ETDRS letters in the PRN cohort compared to 7.3 ± 2.8 ETDRS letters in the monthly cohort (p=0.68). A reduction in mean CFT of 64.5 ± 13.3 and 96.3 ± 22.0 μm occurred in the PRN and monthly cohorts, respectively (p=0.22). Macular function assessed with mfERG decreased comparably in both the PRN and monthly cohorts (p=0.33). For all patients, average mean sensitivity significantly improved by 1.7 ± 0.5 dB (p<0.05) and N1-P1 response density significantly decreased by 0.52 ± 0.21 nV/deg (p<0.05). Conclusion: Both PRN and monthly treatment of exudative AMD with ranibizumab improve visual function as assessed by BCVA and MP. Macular thickening also improved as demonstrated by HR-OCT findings. However, the decreased retinal function noted by mfERG suggests that some loss of retinal function still occurs despite effective treatment. These measures of visual function may be useful in assessing retinal health and response to treatment in future clinical trials.
In uence of GSTT1 and GSTP1 Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Retinopathy Risk in The Chinese Population: A Case Control Study

Xinqian Geng The Second People's Hospital of Yunnan Province Ling Zha The People's Hospital of Fengqing Taicheng Zhou The second People's Hospital of Yunnan Province Yuxin Xiong The second People's Hospital of Yunnan Province Fan Xu The Second People's Hospital of Yunnan Province Bo Xu The second People's Hospital of Yunnan Province Feiying Wang The Second People's Hospital of Yunnan Province Xiaoling Wang The Second People's Hospital of Yunnan Province Ke Yang Shanghai Jiao Tong University Medical School A liated Ruijin Hospital Department of Cardiology Laboratory Wenyu Tao The Second People's Hospital of Yunnan Province Yiping Li The Second People's Hospital of Yunnan Province Ying Yang (  yangying2072@126.com ) The Second People’s Hospital of Yunnan Province https://orcid.org/0000-0001-5753-7106
AN AYURVEDIC DRUG FOR TRUE INTEGRATION: THERAPEUTIC BENEFITS OF ASHWAGANDHA AND CURRENT STATE-OF-THE-ART.

: Ashwagandha [Withania somnifera Dunal] is known for health benefits from thousands of years. Its therapeutic benefits can be dated back to most ancient Ayurvedic texts Sushrut samhita and Charaka samhita. The paper reviews ancient and latest state-of-the-art of this medicinal plant. This review focuses on traditional Ayurvedic methods of using Ashwagandha and its main formulations for various actions, mainly rejuvenator and life enhancing. It also review the current state-of-the-art , and promotes use of Ashwagandha as a integrative adjuvant for treatment of neuropsychological diseases, cancer, infertility and in sports medicine. In this paper, The most recent primary research from based on Ashwagandha were reviewed. Information from traditional ancient Ayurvedic classics have been reviewed in the paper with focus on the traditional formulations and efficacy. Articles from PubMed/ MEDLINE database published after 2017 till August 2019 have been selected. The unique methods of medicine formulations and extraction methods of Ayurveda are highlighted. Ashwagandha is a largely studied plant and its ethnopharmacological uses are justified by latest researches. True integration of Ayurveda and allopathic medicine is necessary for effective healthcare. Promising anti-cancer action of this herb justifies its benefits for integrative treatment. The traditional formulations of Ashwagandha are easy to prepare, easy to use and low on cost. The review highlights therapeutic potential of Ashwagandha, and highlights classical formulations.
Autism: “Leaky Gut”, Prematurity and Lactoferrin

Children with autism frequently suffer from a variety of gastrointestinal (GI) problems, referred to as “leaky gut”, exhibit increased levels of pathogenic bacterial species, and interestingly, show higher prevalence of inflammatory bowel disease (IBD). It has been proposed that abnormal gut development may contribute to these problems. In turn, delayed gut development may affect the gut-brain axis communication and lead to altered brain development implicated in autism. In the premature infants IBD occurs primarily in the form of necrotizing enterocolitis (NEC). Importantly, the rate of both premature births and autism has been on an increase. These observations suggest that the GI problems present in subpopulations of autistic children may be related to prematurity. The preterm infant’s gut with underdeveloped gut lining, affects its ability to make a transition to the external milieu and the first bacterial colonization, which affect the subsequent development of the gut and the gut-brain axis impacting brain development. Lower levels of the brain-derived neurotrophic factor (BDNF) in premature infants may further affect brain maturation. Additionally, premature infants are often fed formulas devoid of essential bioactive factors such as lactoferrin (LF), present in the human colostrum and milk, and critical for both gut and brain maturation. Even when LF is used as a supplement, in infant formulas, it is present in low concentration and is mostly of bovine origin; recent research suggests species-specificity of LF. This review discusses: (1) the delay in gut maturation in preterm infants, (2) early nutritional practices in preterm infants, and (3) species-specific structure-function relationship of LF. It considers the possible link between gut immaturity and autistic pathology. It concludes with a suggestion that breastfeeding or/and native human LF supplementation may play a preventive role in autism.
Impact of Network and Service Paradigm Shift on Evolution of the QoE and QoS Concepts

—We are witnessing a number of paradigm shifts in many Information and Communication Technology (ICT) areas. 5G, Future Internet and very high resolution digital TV defined a new vision of services with novel approaches to their implementation, deployment and operation based on concepts of Software Defined Network (SDN) and Network Function Virtualization (NFV). Increasing transmission capabilities in both mobile and fixed networks became an enabler for a new generation of multimedia services and applications. Evolution of digital video technology and competition of operator supported services with Over The Top (OTT) applications caused change in understanding of Quality of Service (QoS) and Quality of Experience (QoE) concepts. This paper surveys the change of QoE approaches and interpretation in the context of new services and applications.
THE TRUE R 2 AND THE TRUTH ABOUT R 2

In this paper our goal is to explain the distribution of the sample coeﬃcient of determination in the simple regression case. We do this by using its relationship to the noncentral F distribution. But ﬁrst we introduce a new term, the true coeﬃcient of determination. In a simulation study it is feasible to know the true coeﬃcient of determination because the variance of the error term is known. The usefulness of the true coeﬃcient of determination is in the built of relationships with predetermined strength. It answers the question: How much error should we add? The answer depends on how strong we want the association in the simple regression model to be. Once we determine this we can compute the noncentrality parameter and explain the distribution of the sample coeﬃcient of determination. It is a simple way of explaining the distribution of the sample coeﬃcient of determination and it is interesting at least from the educational point of view.
Formulation and evaluation of herbal ointment using leaves of Thuja orientalis l. Leaf extract

The study of diseases and their treatment are important part of our ancient time worldwide. The knowledge of medicinal plants must have been accumulated in the course of many centuries. Herbal plants are huge sources of neutraceuticals, prevent the different disease or maintain healthy life. Plant produces primary metabolites for their basic survival and secondary metabolites for their ecological, taxonomical and biochemical differentiation and diversity. Herbal medicine prepare different part of plant are used. Herbal drug is design as the alternative formulation for the external use in the form of ointment. For the clinical use the herbal ointment apply externally on human body. The main aims of this research are preparation of herbal ointment from the Thuja orientalis L.Plants used as antibacterial activity. Under this research work, it is design as herbal ointment with the help of Ethanolic extract of Thuja orientalis L. and determines the anti bacterial capacity on it. In vitro study the antibacterial activity of the Ethanolic extracts of dried leaves of Thuja orientalis L. are determine by using the Agar cup plate method versus different bacteria such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa etc. By blending the Ethanolic extract of Thuja orientalis L. (10 % w/w) into aqueous cream we formulated herbal ointment. The emulsifying agent and simple ointment bases are added in above herbal ointment for increase the antibacterial effectiveness during in vitro evaluation. Thuja orientalis L. (Family Cupressaceae) are broadly used in traditional system of medicine throughout different part of India, China, Russia, Korea, Japan, India, Florida and Iran. It is used in the treatment of diarrhea, cough, cold, bronchitis, and upper part repertory infection. The current study deals with the determination of formulation and evaluation of herbal ointment using Thuja orientalis leave extract.
LSTM-Based Models for Stock Price Forecast

Designing robust and accurate predictive models for stock price prediction has been an active area of research for a long time. At the same time, supporters of the efficient market hypothesis believe that it is impossible to predict stock prices accurately. Formal propositions demonstrate that accurate modeling and designing appropriate variables may lead to models using which stock prices and stock price movement patterns can be accurately predicted. Researchers have also worked on technical analysis of stocks intending to identify patterns in the stock price movements using advanced data mining techniques. Deep learning technology is a new emerging technology that can effectively process time-series data and multi-period data. At the same time, the combination of multiple models usually has better performance than a single model and is becoming the main direction in stock price prediction(Ji et al., 2021). In this research, the objective was to utilized LSTM based models for stock trend predictions. For my study, I have used S&P 500 index values for 20 years as data. An RNN model was used as a benchmark. In comparison, four kinds of LSTM models, including Vanilla LSTM, Stacked LSTM, Bidirectional LSTM and CNN-LSTM were built. In this work, the input was the daily close price of the S&P 500 index, the output of the model was compared with the actual stock price data by using root mean squared error.
OTT_A_238958 2833..2842

Hongchun Li Miao Chen Zhuying Yang Qinxian Wang Jiesheng Wang Dong Jin Xiuyun Yang Fuxing Chen Xiumin Zhou Kexue Luo 1Department of Cadre Health, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang, People’s Republic of China; 2Department of Oncology, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang, People’s Republic of China; 3Department of Gastroenterology, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang, People’s Republic of China; 4Department of Pharmacy, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang, People’s Republic of China Introduction: Pancreatic cancer (PC) is one of the leading causes of cancer, with the lowest 5-year survival rate of all cancer types. Given the fast metastasis of PC and its resistance to surgery, radiotherapy, chemotherapy, and combinations thereof, it is imperative to develop more effective anti-PC drugs. Phillygenin (PHI) has been reported to exert anti-cancer, antibacterial, and anti-inflammatory properties. However, the mechanism of PHI in the development of PC is still unclear. Methods: The cytotoxicity of PHI in pancreatic cancer cells was evaluated by MTT assay, and clonogenic assay was used to test the anti-proliferation of PHI. The pro-apoptotic effect of PHI was detected by flow cytometry analysis. The changes of epithelial–mesenchymal transition (EMT) in pancreatic cancer cells treated with PHI were determined by Western blot. Transwell assay was used to test the migration and invasion of PC cells after treatment with PHI. Molecular docking was used to predict the potential binding site of candidate target with PHI. Results: PHI could inhibit the proliferation, migration, and EMT of PC cells (PANC-1 and SW1990) and induce its apoptosis. Analysis of the Cancer Genome Atlas database indicated that elevated MELK levels correlated with poor overall survival (OS) and disease-free survival (DFS) of PC patients. In addition, molecular modeling showed that PHI may potentially target the catalytic domain of maternal embryonic leucine zipper kinase (MELK). Overexpression of MELK muted the anti-PC effects of PHI. Conclusion: PHI holds promise as a potent candidate drug for the treatment of PC via targeted MELK.
EFFECT OF LAVANDULA OFFICINALIS HYDROALCOHOLIC EXTRACT ON BLOOD CELLS FACTORS IN MICE

: In this study, the effect of hydroalcoholic extract of lavender plant on the number of blood cells in small laboratory mice was investigated. Due to the medicinal use of lavender and some of its therapeutic effects, its effect on blood cell count is an important indicator in determining its positive and negative effects. In this study, 50 small female laboratory mice were divided into 5 control groups, placebo, 50 mg/kg dose, 100 mg/kg dose and 200 mg/kg dose and were treated with lavender extract for 20 days. After blood sampling and blood cell counting with an auto analyzer, a significant reduction in total white blood cell count was achieved in all three treatment groups, which was more significant with increasing dose. And in doses of 50 mg/kg and 100 mg/kg decreased the number of red blood cells. And hemoglobin levels of red blood cells and MCV and MCH indicators increased significantly. And the number of blood platelets was reduced at a dose of 200 mg/kg
Bovine Trypanosomosis and Tsetse Fly Density in Seyo District, Kellem Wollega Zone, Western Ethiopia

A cross-sectional study was conducted from May to June 2014 with the objectives of determining the prevalence of bovine trypanosomasis and the apparent density of tsetse flies in selected four villages of Seyo district, Western Ethiopia. For the prevalence and PCV determination, conventional parasitological and hematological techniques were employed, whereas for the entomological survey of vectors odor baited mono-pyramidal traps were deployed. The prevalence study revealed that, out of total of 312 cattle examined, 41 (13.14%) were found infected with trypanosomes. This result showed that infection rate among peasant associations, age, body condition and sex of the animals were not found significant to influence the prevalence of the disease (P>0.05). Two species of trypanosomes were isolated including Trypanosoma conglense and T. vivax and mixed of the two species. The mean PCV was significantly (P<0.05) lower (25.37%) in parasitaemic animals as compared to aparasitaemic animals (27.18%). During the entomological survey, three species of the tsetse flies ( Glossina pallidipes, G. morsitans submorsitans and G. tachnoides ) were identified. The overall apparent density of tsetse flies species caught was 4.27 Flies per Trap per Day (FTD). This particular study, taken as a whole, evidenced that tsetse fly and bovine trypanosomasis has continued to be a disease of major concern to cattle of the study area warranting an integrated intervention of the disease and its vectors to safeguard livestock production and productivity in the study area.
Implementation and Performance Evaluation of Eavesdropping Protection Method over MPTCP Using Data Scrambling and Path Dispersion

—In order to utilize multiple communication interfaces installed mobile terminals, Multipath Transmission Control Protocol (MPTCP) has been introduced recently. It can establish an MPTCP connection that transmits data segments over the multiple interfaces, such as 4G and Wireless Local Area Network (WLAN), in parallel. However, it is possible that some interfaces are connected to untrusted networks and that data transferred over them is observed in an unauthorized way. In order to avoid this situation, we proposed a method to improve privacy against eavesdropping using the data dispersion by exploiting the multipath nature of MPTCP in our previous papers. The proposed method takes an approach that, if an attacker cannot observe the data on every path, he/she cannot observe the traffic on any path. The fundamental techniques of this method is a per-byte data scrambling and path dispersion. In this paper, we present the result of implementing the proposed method within the Linux operating system and its performance evaluation in more detail than our former papers.
Speaker Recognition Using Discrete Wavelet Transform and Artificial Neural Networks

Pickup and delivery problems constitute an important class of vehicle routing problems in which objects have to be collected and distributed. This paper discusses a heuristic approach called Repetitive Nearest Neighbour Algorithm to solve Travelling Salesman Problem, to determine the tour the vehicle should follow so that the total distance travelled is minimized. The algorithm was tested in planning the best route which connects a set number of shops; the shops were distributed within an area of 20km by 20km, also the algorithm used to locate the best seed when computing the optimum tour. The overall minimum cost computed for cases of different shop numbers, between 10 and 500 shops. The coordinates for each shop on an X,Y map was generated and recorded, then a distance matrix was calculated which shows the cost of traveling between all shops in km. The computation time for the algorithm was recorded for each case. The aim of this paper is to apply a Traveling Salesman Problem (TSP) algorithm to solve real world problems by helping traffic managers of freight transport companies to reduce operational costs via shorter routes and optimized distribution maps. In order to do so effectively, TSP implementation is to be optimized to reduce computation time. In this paper, a nearest neighbour greedy algorithm based approach for solving the TSP effectively is presented
Proposal for testing lepton univerality in upsilon decays at a B factory running at Υ(3 S ) ∗

A proposal is presented for detecting new physics at a B factory running at the Υ(3 S ) resonance by testing lepton universality to the few percent level in the leptonic decays of the Υ(1 S ) and Υ(2 S ) resonances tagged by the dipion in the chain decay: Υ(3 S ) → π + π − Υ(1 S, 2 S ); Υ(1 S, 2 S ) → ℓ + ℓ − , ℓ = e, µ, τ .
Deployment of operational performance indicators in failure mode effect and analysis application: a literature review and classification

Failure mode effect and analysis (FMEA) is a well-known methodology for improving operational performance, such as the quality, cost, and delivery time of a product, process, or system. However, the success of FMEA in operational performance cannot be quantified at present. The risk priority number (RPN), which is the only indicator of FMEA, has no relationship with operational performance. For example, a reduction in RPN may not benefit operational performance, particularly if the corrective action is to enhance detection. Thus, the capability of FMEA to improve operational performance cannot be validated unless it demonstrates quantifiable operational performance. An organisation is distinct from its competitors based on its operational performance and not based on RPN. The missing operational performance measurement practice in FMEA is essential for further strengthening the FMEA methodology. This study aims to identify the most effective methodology and approach for quantifying the success of FMEA in operational performance through a systematic review and to classify FMEA articles that measured operational performance.
Efficient removal of siloxanes and VOCs from sewage biogas by an anoxic biotrickling filter supplemented with activated carbon

The removal of siloxanes (D4 and D5) and volatile organic contaminants (hexane, toluene and limonene) typically found in sewage biogas was investigated in a lab-scale biotrickling filter (BTF) packed with lava rock under anoxic conditions. Complete removal efficiencies for toluene and limonene were recorded at all empty bed residence time (EBRT) tested. The influence of EBRT was remarkable on the abatement of D5, whose removal decreased from 37% at 14.5 min to 16% at 4 min, while the removal of D4 and hexane remained below 16%. The packing material was supplemented with 20% of activated carbon aiming at increasing the mass transfer of the most hydrophobic pollutants. This strategy supported high removal efficiencies of 43 and 45% for hexane and D5 at the lowest EBRT. CO 2 and silica were identified as mineralization products along with the presence of metabolites in the trickling solution such as dimethylsilanediol, 2- carene and α -terpinene.
Institutional Knowledge at Singapore Management University Merleau-Ponty on Human Motility and Libet's Paradox

In 1979, neuroscientists Libet, Wright, Feinstein and Pearl introduced the “delay-and-antedating” hypothesis/paradox based on the results of an on-going series of experiments dating back to 1964 that measured the neural adequacy [brain wave activity] of “conscious sensory experience”. What is fascinating about the results of this experiment is the implication, especially when considered in the light of Merleau-Ponty’s notions of “intentionality” and the “pre-reflective life of human motility”, that the body, and hence not solely the mind, is a thinking thing. The experiments and conclusions of Libet et al. have attracted considerable academic attention and have been used in the development of psychological theories on automotivism and the adaptive unconscious. Moreover, they have engendered a series of important considerations in respect of the question of free will. This paper outlines the connections between the findings of Libet et al. and Merleau-Ponty’s ontology as presented in the Phenomenology of Perception (1945/1962). It is not our intention to argue that the former amounts to new wine in old bottles, but rather to show counterfactually (since we offer no new scientific data and assume the conclusions of the experiments) that Merleau-Ponty’s ontology provides a theoretical framework which explains the experimental data obtained by Libet et al., and provides further speculative confirmation of the work stemming from neuro-physical research and emerging theories on the adaptive unconscious.