Miracle-dz/UniFAR-FTUs huggingface dataset:
THE ENERGY GAP IN NUCLEAR MATTER

The magnitude of the energy gap in nuclear matter associated with a highly correlated ground state of the type believed to be important in the theory of superconductivity has been evaluated theoretically. The integral equation of Cooper, Mills, and Sessler is linearized and transformed into a form suitable for numerical solution. The energy gap, calculated by using an appropriate single-particle potential and the Gammel-Thaler two-body potential, is found to be a very strong function of the density of nuclear matter, and of the effective mass at the Fermi surface. It is concluded that the magnitude of the energy gap for nuclear matter should not be compared directly with experimental values for finite nuclei, although the results suggest that if the theory is extended to apply to finite nuclei it probably would be in agreement with experiment.
Functional magnetic resonance imaging activation for different vergence eye movement subtypes

Maddox suggested that there were four convergence subtypes, each driven by a different stimulus. The purpose of this study was to assess the neural correlates for accommodative convergence, proximal convergence (convergence stimulus provided), disparity convergence and voluntary convergence (no specific convergence stimulus provided) using functional magnetic resonance imaging (fMRI).
Association of the plasma complement system with brain volume deficits in bipolar and major depressive disorders

Abstract Background Inflammation plays a crucial role in the pathogenesis of major depressive disorder (MDD) and bipolar disorder (BD). This study aimed to examine whether the dysregulation of complement components contributes to brain structural defects in patients with mood disorders. Methods A total of 52 BD patients, 35 MDD patients, and 53 controls were recruited. The human complement immunology assay was used to measure the levels of complement factors. Whole brain-based analysis was performed to investigate differences in gray matter volume (GMV) and cortical thickness (CT) among the BD, MDD, and control groups, and relationships were explored between neuroanatomical differences and levels of complement components. Results GMV in the medial orbital frontal cortex (mOFC) and middle cingulum was lower in both patient groups than in controls, while the CT of the left precentral gyrus and left superior frontal gyrus were affected differently in the two disorders. Concentrations of C1q, C4, factor B, factor H, and properdin were higher in both patient groups than in controls, while concentrations of C3, C4 and factor H were significantly higher in BD than in MDD. Concentrations of C1q, factor H, and properdin showed a significant negative correlation with GMV in the mOFC at the voxel-wise level. Conclusions BD and MDD are associated with shared and different alterations in levels of complement factors and structural impairment in the brain. Structural defects in mOFC may be associated with elevated levels of certain complement factors, providing insight into the shared neuro-inflammatory pathogenesis of mood disorders.
Enhancing physical education pre-service teachers’ experiences in physical education teacher education (PETE) programmes

The focus of the first study (MacPhail & Tannehill, 2012) was to consider the relationship between ‘structure’ and ‘agency,’ teachers as ‘change agents’ and ‘workplace learning’ and examine the extent to which the social structure of the school and the teaching profession, and / or the capacity of the individual to act independently, ultimately determines a teacher’s behaviour in reaction to teaching expectations. We were interested as PETE faculty in how we (1) strive to help pre-service teachers examine and reframe assumptions about themselves as teachers and change agents, and (2) examine taken-forgranted school practices and processes. We shared three critical incidents that portrayed experiences across a sample of beginning teachers in response to their workplace conditions; transitioning from PETE to teaching in a school, isolation as a (un)welcomed form of autonomy, and the legitimacy of physical education in the school. A short commentary follows each critical incident before sharing ways in which PETE programs could strive towards encouraging the agency of the pre-service teacher and in particular, the relationship between initial teacher education and induction. For example, we suggest that one way in which to ease the critical incident of transitioning from a PETE programme to beginning to teach in a school is the development of a professional portfolio to include evidence of their preparation to teach including, (1) a teaching metaphor analysed, revisited, and revised that reflects their philosophy of teaching, (2) a professional development plan to guide their first year of teaching, (3) planning for physical education advocacy in their teaching practice school, and (4) a response/reaction to recent developments in school physical education. The professional development plan would be expected to be the most obvious requirement of the portfolio linked to the ‘bridge building’ between initial teacher education and induction. In compiling their professional development plan, pre-service teachers could be asked to identify at least three areas in which they would like to improve during their first year of teaching, design at least one goal for each of these areas, identify strategies they intend to use to assist them in reaching each goal, and identify a timeline to achieve the goal.
“SIT” with Emx1‐NuTRAP Mice: Simultaneous INTACT and TRAP for Paired Transcriptomic and Epigenetic Sequencing

Epigenetic regulation of transcription is gaining increasing importance in the study of neurobiology. The advent of sequencing technology has enabled the study of this regulation across the entire genome and transcriptome. However, modern methods that allow the correlation of transcriptomic data with epigenomic regulation have had several key limitations, including use of separate tissue sources and detection of low‐expression genes. This article describes a method combining isolation of nuclei tagged in specific cell types (INTACT) with translating ribosome affinity purification (TRAP) in the same cell homogenate, referred to as Simultaneous INTACT and TRAP (SIT). We used this technical approach to directly couple transcriptomic sequencing with epigenomic data in neurons derived from the mouse hippocampus. We demonstrate this method with an Emx1‐NuTRAP transgenic mouse model. Here, we present protocols for SIT and for the generation and validation of the Emx1‐NuTRAP mouse model that we used to demonstrate SIT. These methods enable cell type–specific comparison of translating mRNA and chromatin data from the same set of cells. Using SIT and the Emx1‐NuTRAP transgenic mouse model, researchers can compare epigenomic data to transcriptomic data in the same set of hippocampal excitatory neurons. © 2022 The Authors. Current Protocols published by Wiley Periodicals LLC.
The Glymphatic System: a Potential Key Player in Bacterial Meningitis

The glial-lymphatic system (glymphatic system) is a recently characterized fluid clearance pathway of the central nervous system. Glymphatic system disfunctions leading to defects in drainage of the cerebrospinal fluid have been associated with several neurological disorders. In their article, J. ABSTRACT The glial-lymphatic system (glymphatic system) is a recently characterized fluid clearance pathway of the central nervous system. Glymphatic system disfunctions leading to defects in drainage of the cerebrospinal fluid have been associated with several neurological disorders. In their article, J. S. Generoso, S. Thorsdottir, A. Collodel, R. R. E. Santo, et al. (mBio 13:e01886-22, 2022, https://doi.org/10.1128/mBio.01886-22) have now associated impaired glymphatic system functionality to neurological sequelae of murine meningitis caused by Streptococcus pneumoniae. Their work provides an initial and important step into the systematic evaluation of a potential impact of glymphatic system functionality on disease severity and sequelae in meningitis.
Jacobi Operators and Completely Integrable Nonlinear Lattices

Jacobi operators: Jacobi operators Foundations of spectral theory for Jacobi operators Qualitative theory of spectra Oscillation theory Random Jacobi operators Trace formulas Jacobi operators with periodic coefficients Reflectionless Jacobi operators Quasi-periodic Jacobi operators and Riemann theta functions Scattering theory Spectral deformations-Commutation methods Completely integrable nonlinear lattices: The Toda system The initial value problem for the Toda system The Kac-van Moerbeke system Notes on literature Compact Riemann surfaces-A review Hergoltz functions Jacobi difference equations with MathematicaR Bibliography Glossary of notations Index.
The Global Regulator MftR Controls Virulence and Siderophore Production in Burkholderia thailandensis

Bacterial pathogens face iron limitation in a host environment. To overcome this challenge, they produce siderophores, small iron-chelating molecules. ABSTRACT Burkholderia thailandensis is a member of the Burkholderia pseudomallei complex. It encodes the transcription factor MftR, which is conserved among the more pathogenic Burkholderia spp. and previously shown to be a global regulator of gene expression. We report here that a B. thailandensis strain in which the mftR gene is disrupted is more virulent in both Caenorhabditis elegans and onion. The ΔmftR strain exhibits a number of phenotypes associated with virulence. It is more proficient at forming biofilm, and the arcDABC gene cluster, which has been linked to anaerobic survival and fitness within a biofilm, is upregulated. Swimming and swarming motility are also elevated in ΔmftR cells. We further show that MftR is one of several transcription factors which control production of the siderophore malleobactin. MftR binds directly to the promoter driving expression of mbaS, which encodes the extracytoplasmic function sigma factor MbaS that is required for malleobactin production. Malleobactin is a primary siderophore in B. thailandensis as evidenced by reduced siderophore production in mbaS::Tc cells, in which mbaS is disrupted. Expression of mbaS is increased ~5-fold in ΔmftR cells, and siderophore production is elevated. Under iron-limiting conditions, mbaS expression is increased ~150-fold in both wild-type and ΔmftR cells, respectively, reflecting regulation by the ferric uptake regulator (Fur). The mbaS expression profiles also point to repression by a separate, ligand-responsive transcription factor, possibly ScmR. Taken together, these data indicate that MftR controls a number of phenotypes, all of which promote bacterial survival in a host environment. IMPORTANCE Bacterial pathogens face iron limitation in a host environment. To overcome this challenge, they produce siderophores, small iron-chelating molecules. Uptake of iron-siderophore complexes averts bacterial iron limitation. In Burkholderia spp. , malleobactin or related compounds are the primary siderophores. We show here that genes encoding proteins required for malleobactin production in B. thailandensis are under the direct control of the global transcription factor MftR. Repression of gene expression by MftR is relieved when MftR binds xanthine, a purine metabolite present in host cells. Our work therefore identifies a mechanism by which siderophore production may be optimized in a host environment, thus contributing to bacterial fitness.
Fiducial cross section measurements of top quark pair production in association with a photon at $\sqrt{s} = 13$ TeV with the ATLAS detector

Top-quark pairs in association with final state particles are produced in large quantities at the LHC due to the high centre-of-mass energy available in proton-proton collisions. One such topology is that of a prompt photon radiated from the top quark in addition to the final state particles from the top quark decay. Using 36.1 fb$^{-1}$ of data collected at $\sqrt{s}$ = 13 TeV with the ATLAS detector, fiducial cross-section results are shown in the single-lepton and dilepton channels. Object-level and event-level neural networks are used to increase sensitivity.
Critical Phenomena in 3.99 Dimensions

Landau's mean field theory of critical phenomena is corrected to take fluctuations into account. It is shown that fluctuations of intermediate wavelengths are the crucial effect producing non‐classical exponents (intermediate wavelengths are much larger than the range of forces, much smaller than the correlation length). A simple‐minded analysis of these fluctuations produces improved exponents for spatial dimension d less than 4. The exponents have an expansion in e = d−4. The Landau theory is the 0th order term; the terms of order e give better agreement with experiment than Landau theory. Terms of order e2 have been calculated using a more sophisticated theory.
Design and Development of Wireless Communication Transceiver to Support RFID Reader at UHF Band

This paper discusses the design and development of wireless transceiver to support communication between Radio Frequency Identification (RFID) reader and host computer. The transceiver is designed and developed to operate at Ultra High Frequency (UHF) band thus improving the present communication system between the reader and host computer. Presently, RFID reader communicates through wire with host computer. By using wire communication system, the reading and writing range from RFID reader to the transponder is limited, not portable and inconvenient to users. Besides, wire communication between RFID reader and host is not suitable for outdoor applications as farming, animal inventory and property tagging. The proposed wireless communication transceiver is operated at (UHF) band and uses digital amplitude shift keyed (ASK) modulation to modulate the RFID information. The wireless transceiver can fully support, without error, nearly up to 30 meters in line of sight (LOS) and non-line of sight (NLOS). The RF transmitter is connected to the RFID reader, and the RF receiver is connected to the host computer. The scanned RFID data can be read by more than one host computer in real time, thus it is suitable for indoor and outdoor applications, convenient and user friendly.
Comparing the Relationships of Genetically Proxied PCSK9 Inhibition With Mood Disorders, Cognition, and Dementia Between Men and Women: A Drug‐Target Mendelian Randomization Study

Background PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors are important therapeutic options for reducing cardiovascular disease risk; however, questions remain regarding potential differences in the neuropsychiatric impact of long‐term PCSK9 inhibition between men and women. Methods and Results Using PCSK9 gene single‐nucleotide polymorphisms from European ancestry–based genome‐wide association studies of low‐density lipoprotein cholesterol (N=1 320 016), circulating PCSK9 protein levels (N=10 186), tissue‐specific PCSK9 gene expression, sex‐specific genome‐wide association studies of anxiety, depression, cognition, insomnia, and dementia (ranging from 54 321 to 194 174), we used drug‐target inverse variance–weighted Mendelian randomization (MR) and complementary MR methods (MR Egger, weighted median, and weighted mode) to investigate potential neuropsychiatric consequences of genetically proxied PCSK9 inhibition in men and women. We failed to find evidence surpassing correction for multiple comparisons of relationships between genetically proxied PCSK9 inhibition and the risk for the 12 neuropsychiatric end points in either men or women. Drug‐target analyses were generally well‐powered to detect effect estimates at several hypothesized thresholds for both combined‐sex and sex‐specific end points, especially analyses using PCSK9 instruments derived from protein and expression quantitative trait loci. Further, MR estimates across complementary MR methods and additional models using genetic instruments derived from circulating PCSK9 protein levels and tissue‐specific PCSK9 expression were in alignment, strengthening causal inference. Conclusions Genetically proxied PCSK9 inhibition showed a neutral neuropsychiatric side effect profile with no major sex‐specific differences. Given statistical power considerations, replication with larger samples, as well as data from other ancestral populations, are necessary. These findings may have important clinical implications for lipid‐lowering drug‐prescribing practices and side effect monitoring of approved and future PCSK9 therapies.
The photic field

"The Photic Field" brings a formal elegance and completeness to the portion of geometrical optics that deals with amounts of radiant energy. Since the time of Lambert, this discipline has been handled piecemeal by a great variety of methods. But by utilizing the full potentialities of field theory, the book unifies the subject and forges a powerful tool for handling practical applications. Such applications include solar heating, lighting design, photographic exposure, and color specification.The pharosage vector is used throughout the book, and divergence, curl, and gradient are employed. Potentials and quasi-potentials are important, and contour integration allows a double integral to be replaced by a single integral. These and other aspects of field theory will allow the reader to solve photometric problems that were previously difficult to formulate.Many of the formulations in geometrical optics, although conceptually clear, are computationally unwieldy. As a result, researchers until quite recently have had to rely on a scattered collection of rules of thumb and approximation methods. But now, with the general availability of computer, exact solutions are within range, and thus many of the equations given in "The Photic Field" may be directly applied almost for the first time.
Enzyme Immobilization on Metal Organic Frameworks: the Effect of Buffer on the Stability of the Support

Metal organic frameworks (MOFs) have been used to encapsulate an array of enzymes in a rapid and facile manner; however, the stability of MOFs as supports for enzymes has not been examined in detail. This study examines the stability of MOFs with different compositions (Fe-BTC, Co-TMA, Ni-TMA, Cu-TMA, and ZIF-zni) in buffered solutions commonly used in enzyme immobilization and biocatalysis. Stability was assessed via quantification of the release of metals by inductively coupled plasma optical emission spectroscopy. The buffers used had varied effects on different MOF supports, with incubation of all MOFs in buffers resulting in the release of metal ions to varying extents. Fe-BTC was completely dissolved in citrate, a buffer that has a profound destabilizing effect on all MOFs analyzed, precluding its use with MOFs. MOFs were more stable in acetate, potassium phosphate, and Tris HCl buffers. The results obtained provide a guide for the selection of an appropriate buffer with a particular MOF as a support for the immobilization of an enzyme. In addition, these results identify the requirement to develop methods of improving the stability of MOFs in aqueous solutions. The use of polymer coatings was evaluated with polyacrylic acid (PAA) providing an improved level of stability. Lipase was immobilized in Fe-BTC with PAA coating, resulting in a stable biocatalyst with retention of activity in comparison to the free enzyme.
Statistical mechanics of the majority game

The majority game, modelling a system of heterogeneous agents trying to behave in a similar way, is introduced and studied using methods of statistical mechanics. The stationary states of the game are given by the (local) minima of a particular Hopfield-like Hamiltonian. On the basis of replica symmetric calculations, we draw the phase diagram, which contains the analogue of a retrieval phase. The number of metastable states is estimated using the annealed approximation. The results are confronted with extensive numerical simulations.
High altitude differentially modulates potassium channel‐evoked vasodilatation in pregnant human myometrial arteries

High‐altitude (>2500 m or 8200 ft) residence reduces uterine artery blood flow during pregnancy, contributing to an increased incidence of preeclampsia and intrauterine growth restriction. However, not all pregnancies are affected by the chronic hypoxic conditions of high‐altitude residence. K+ channels play important roles in the uterine vascular adaptation to pregnancy, promoting a reduction in myogenic tone and an increase in blood flow. We hypothesized that, in pregnancies with normal fetal growth at high altitude, K+ channel‐dependent vasodilatation of myometrial arteries is increased compared to those from healthy pregnant women at a lower altitude (∼1700 m). Using pharmacological modulation of two K+ channels, ATP‐sensitive (KATP) and large‐conductance Ca2+‐activated (BKCa) K+ channels, we assessed the vasodilatation of myometrial arteries from appropriate for gestational age (AGA) pregnancies in women living at high or low altitudes. In addition, we evaluated the localization of these channels in the myometrial arteries using immunofluorescence. Our results showed an endothelium‐dependent increase in KATP‐dependent vasodilatation in myometrial arteries from high versus low altitude, whereas vasodilatation induced by BKCa activation was reduced in these vessels. Additionally, KATP channel co‐localization with endothelial markers was reduced in the high‐altitude myometrial arteries, which suggested that the functional increase in KATP activity may be by mechanisms other than regulation of channel localization. These observations highlight an important contribution of K+ channels to the human uterine vascular adaptation to pregnancy at high altitude serving to maintain normal fetal growth under conditions of chronic hypoxia.
Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study

Rationale In 2016, a new interferon-gamma release assay (IGRA) was introduced, QuantiFERON-TB Gold Plus (QFT-Plus), claimed to have improved sensitivity in active tuberculosis (TB). Objectives This study aimed to determine the performance of QFT-Plus, compared with previous generation IGRAs and the tuberculin skin test (TST), in children with TB in Europe. Methods Multicentre, ambispective cohort study within the Paediatric Tuberculosis Network European Trials Group (ptbnet), a dedicated paediatric TB research network comprising >300 members, capturing TB cases <18 years-of-age diagnosed between January 2009 and December 2019. Measurements and main results 1001 TB cases from 16 countries were included (mean age (IQR) 5.6 (2.4–12.1) years). QFT-Plus was performed in 358, QFT Gold in-Tube (QFT-GIT) in 600, T-SPOT.TB in 58 and TST in 636 cases. The overall test sensitivities were: QFT-Plus 83.8% (95% CI 80.2% to 87.8%), QFT-GIT 85.5% (95% CI 82.7% to 88.3%), T-SPOT.TB 77.6% (95% CI 66.9% to 88.3%) and TST (cut-off ≥10 mm) 83.3% (95% CI 83.3% to 86.2%). There was a trend for tests to have lower sensitivity in patients with miliary and/or central nervous system (CNS) TB (73.1%, 70.9%, 63.6% and 43.5%, respectively), and in immunocompromised patients (75.0%, 59.6%, 45.5% and 59.1%, respectively). Conclusions The results indicate that the latest generation IGRA assay, QFT-Plus, does not perform better than previous generation IGRAs or the TST in children with TB disease. Overall, tests performed worse in CNS and miliary TB, and in immunocompromised children. None of the tests evaluated had sufficiently high sensitivity to be used as a rule-out test in children with suspected TB.