Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of organic and inorganic fertilizers on growth and yield of red ginger (Zingiber officinale Rosc.).

Ginger (Zingiber officinale Rosc.) has been used for medicinal purposes in Southeast Asia since ancient times. Yield of ginger is affected by soil where the crop grows, climatic conditions and its cultivation management. Similar to other tuber crops, ginger needs high nutrients on soil. The objective of this experiment was to investigate the growth and yield of red ginger plants grown in media suplemented with organic and inorganic fertilizers. The research was conducted in a glasshouse in the Research Center for Biotechnology LIPI. The treatments tested were factorial between the medium and fertilizers used, with the total of treatments was 16 with 5 replicates of each treatment. Treatment M1 was soil : manure : grit (1:1:1); M2 was soil : manure : chaff (1:1:1); M3 was soil : manure : grit (1:2:1); M4 was soil : manure : chaff (1: 2:1); P0 was no addition of fertilizer control treatment); P1 was NPK granule (18:9:10) at 5 g/plant; P2 was NPK (20:20:20) at 1 g/l given once a week; P3 was NPK (32:10:10) at 1 g/lt giving once a week. Growth and yield parameters measured were height, number of leaves, number of shoots, stem diameter (from 0 to 24 weeks), leaves fresh and dry weight, stem fresh and dry weight, root fresh and dry weight, and leaf area recorded at month 4 and 6. After 9 months, red ginger was harvested to determine its yield. The results indicated that treatment with M2P2 was the best treatment for height, number of leaves and stem diameter, of red ginger, meanwhile M4P3 resulted in the highest number of shoots among the others (11.25). The highest production of rhizome of red ginger plant after 9 month growth was achieved by M1P2 treatment (174.058 gr fresh weight/ polybag and 19.75 dry weight/ polybag). Physiological parameters showed that the highest Leaf Area Index (LAI) value was from M2P2 treatment (3.83 after 4 months of growth), and from M4P3 (6.415448, after 6 month of growth); M3P2 treatment produced the highest net assimilation rate (NAR) at 0.01, M3P1 had the crop growth rate (CGR) value at 0.031548. The best value of Harvest index (HI) was reached by M3P0 treatment at 2.038.
Advance Publication Experimental Animals

To achieve surgical anesthesia in animal experimentation, it is necessary to select the appropriate anesthetic protocol by considering its pharmacological properties and the surgical procedure to be performed. However, few studies have investigated the validity of anesthetic protocols under surgical conditions in small rodents. The present study aimed to clarify the pharmacological properties of 4 anesthetic protocols during the surgical procedure of castration in rats. Eight-week-old male Wistar rats were anesthetized with anesthetics, including the combination of ketamine and xylazine (K/X), the combination of medetomidine, midazolam, and butorphanol (M/M/B), and isoflurane, and sevoflurane. Castration was performed under each anesthesia, and anesthetic depth and times were assessed, as were vital signs. The injectable anesthetics were investigated at standard and high doses. The concentration of inhalant anesthetics was adjusted to 1.5 minimum alveolar concentration (MAC). K/X at both doses demonstrated sufficient anesthetic depth with rapid induction and recovery. However, bradycardia and hypothermia were prominent in high-dose K/X, indicating that the standard-dose is more appropriate for surgical anesthesia in castration procedures. M/M/B demonstrated high anesthetic sensitivity variation in individual animals. In contrast to injectable anesthetics, inhalant anesthetics provided stable anesthetic depth with less cardiorespiratory influence. Sevoflurane did not lead to a significant decrease in rectal temperature during the anesthetic period. Results of the present study revealed the optimal dose and pharmacological features of several anesthetic protocols for castration, and may contribute to the standardization of surgical anesthesia in rats.
Fish protein and lipid interactions on the digestibility and 1 bioavailability of starch and protein from durum wheat pasta 2 3

Fish protein and lipid interactions on the digestibility and 1 bioavailability of starch and protein from durum wheat pasta 2 3 Ajay S. Desai , Margaret A. Brennan 1,2 Xinbo Guo 1,4 , Xin-An Zeng 1,4 & Charles 4 S. Brennan 1,2,3,4* 5 1 School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; 6 ajay.desai@lincolnuni.ac. nz (A.S.D.); charles.brennan@lincoln.ac. nz (C.S.B.); guoxinbo@scut.edu. cn (X.G.); xazeng@scut.edu. cn (X.-A.Z.) 7 2 Department of Wine, Food and Molecular Biosciences, Lincoln University, Christchurch 7647, New Zealand; 8 margaret.brennan@lincoln.ac. nz (M.A.B.) 9 3 Riddet Research Institute, Palmerston North 4442, New Zealand. Charles.brennan@lincoln.ac. nz (C.S.B.) 10 4 Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), 11 Guangzhou 510640, China; charles.brennan@lincoln.ac. nz (C.S.B.); guoxinbo@scut.edu. cn (X.G.); xazeng@scut.edu. cn (X.-A.Z.) 12 *Correspondence: Charles.brennan@lincoln.ac. nz; Tel. : +6434230637 13 14 Abstract 15
The prevalence of obstructive sleep apnea-hypopnea syndrome-related symptoms and their relation to airflow limitation in an elderly population receiving home care

Background: Both airflow limitation and obstructive sleep apnea-hypopnea syndrome (OSAHS)-related symptoms are most prevalent in the elderly population. Previous studies revealed significant associations between OSAHS-related symptoms and obstructive airway diseases in the general population. However, other studies showed that the frequency of OSAHS-related symptoms in patients with obstructive airway diseases decreases after the age of 60 and older. Aims: To investigate the prevalence of OSAHS-related symptoms (snoring, breathing pauses, and excessive daytime sleepiness [EDS]) and their relations to airflow limitation, for people over 65 years old. Methods: A full screening spirometry program was performed in a total of 490 aging participants (mean age 77.5 years – range 65–98) who were attending 16 home care settings in central Greece. Airflow limitation was assessed according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) spirometric criteria (FEV 1 /FVC , 70%). The Berlin Questionnaire and the Epworth Sleepiness Scale were used to screen individuals for OSAHS-related symptoms. Bivariate associations were described using odds ratio (OR) with 95% confidence intervals (CI). Results: Airflow limitation prevalence was 17.1% (male 24.2% and female 9.9%) and was strongly related to male gender and smoking status. The prevalence rates of frequent snoring, breathing pauses, and EDS were 28.1%, 12.9%, and 11.6%, respectively. However, participants with airflow limitation were less likely to report breathing pauses, frequent snoring, EDS, and obesity. Finally, frequent snoring was significantly more common in males than females. Conclusion: This study revealed decreased frequency of OSAHS-related symptoms in participants with airflow limitation suggesting that OSAHS-related symptoms and airflow limitation are not related in our elderly population.
Canaloplasty in the Treatment of Primary Open-Angle Glaucoma: Patient Selection and Perspectives

: Canaloplasty is a surgical procedure that has undergone a number of developments since its introduction in 2005. Many thousands of canaloplasties have been performed around the world since then and is, by de ﬁ nition, a blebless procedure. It does not necessitate the use of any anti ﬁ brotic agents and results in safe and effective IOP reductions in patients with open-angle glaucoma (OAG) with minimal complications and no bleb-related adverse events. When considering the surgical management of patients with early and medium stages of the disease, canaloplasty can be considered as a ﬁ rst line option. This paper will overview the theoretical effectiveness of canal surgery, the fundamental aspects of aqueous out ﬂ ow resistance with particular emphasis on the role of the trabecular meshwork, Schlemm ’ s canal, and the collector channels, and the methods available for the clinical evaluation of the out ﬂ ow pathways in relation to the ocular anatomy. Further, the paper will detail the surgical technique itself and how this has developed over time together with the clinical aspects that should be accounted for when selecting patients for this surgery.
Constructing and enforcing "authentic" identity online: Facebook, real names, and non-normative identities

Despite the participatory and democratic promises of Web 2.0, many marginalized individuals with fluid or non-normative identities continue to struggle to represent themselves online. Facebook users, in particular, are told to use “authentic identities,” an idea reinforced throughout the site’s documentation, “real name” and other policies, and in public statements by company representatives. Facebook’s conception of authenticity and real names, however, has created problems for certain users, as demonstrated by the systematic deactivation of many accounts belonging to transgender and gender variant users, drag queens, Native Americans, abuse survivors, and others. In view of the struggles of marginalized users, Facebook policy appears paradoxical: the site simultaneously demands authenticity yet proscribes certain people from authentic self-presentation. In this work, we examine Facebook’s construction of “authenticity” and show how it excludes multifaceted, fluid, or non-normative identities. Using content analysis and close reading, we analyze site documentation and data from The Zuckerberg Files (an online archive of Facebook founder and CEO Mark Zuckerberg’s public remarks) to understand the platform’s mechanisms for enforcing authenticity. We find that Facebook positions itself as a type of administrative identity registrar, raising vital questions regarding the ethics and consequences of identity enforcement online today.
Human-induced fire regime shifts during 19 th century industrialization : a 1 robust fire regime reconstruction using northern Polish lake sediments 2

1Alfred-Wegener-Institute for Polar and Marine Research, Polar Terrestrial Environmental 6 Systems, Potsdam, Germany 7 2GFZ German Research Centre for Geosciences, Section Climate Dynamics and Landscape 8 Evolution, Potsdam, Germany 9 3Polish Academy of Sciences, Institute of Geography and Spatial Organization, Torun, Poland 10 4Royal Netherlands Institute for Sea Research, Department of Marine Microbiology and 11 Biogeochemistry, and Utrecht University, Texel, The Netherlands 12 5Museum of the Kościerzyna Land, Kościerzyna, Poland 13 6Département de Géographie, Université de Montréal, Montréal, Québec, Canada 14 7GFZ German Research Centre for Geosciences, Section Geomorphology, Potsdam, Germany 15 8Polish Academy of Sciences, Institute of Geological Sciences, Warsaw, Poland 16 9Max Planck Institute for the Science of Human History, Department of Archaeology, Jena, 17 Germany 18 10Kaziemierz Wielki University, Institute of Geography, Bydgoszcz, Poland 19 11Faculty of Geosciences, Utrecht University, The Netherlands 20 12Polish Academy of Sciences, Institute of Geography and Spatial Organization, Warsaw, 21 Poland 22 *Corresponding author : edietze@awi.de (ED) 23
The Effects of Adiponectin on Infertile Women Undergoing IVF/ICSI Treatment and on Human Granulosa Cells

Abstract Adiponectin, one of the most abundant adipocyte-secreted protein, has been involved in female reproductive regulation. This study aimed to 1) compare serum adiponectin levels in various phases of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment including Phase I (the beginning of gonadotropin stimulation), Phase II (around 8 days after gonadotropin stimulation), and Phase III (on the day of ovum pick-up) between success and unsuccess subjects; 2) compare follicular fluid (FF) adiponectin levels between success and unsuccess groups; 3) compare serum adiponectin levels among different phases of IVF/ICSI treatment in success and unsuccess groups; 4) compare the levels of adiponectin between serum and FF; and 5) investigate the effects of adiponectin on mRNA expressions of follicle stimulating hormone receptor (FSHR) and CYP19A1 (aromatase) in human granulosa-like tumor cell line (KGN) (n=3). In the human study, recruited participants (n=30) with age of 26-40 years were enrolled between April 2018 - May 2019. Blood samples were collected at Phases I, II, and III while FF samples were collected at Phase III. Adiponectin levels were comparable between success and unsuccess subjects in both serum (all phases) and FF (Phase III). Furthermore, serum adiponectin levels were comparable among Phase I, II, and III in success and unsuccess groups. In Phase III, serum adiponectin showed positive correlations with serum adiponectin in Phase I and II and serum FSH in Phase I. Interestingly, adiponectin levels in FF were significantly lower than serum at Phase III in unsuccessful pregnancies but were comparable in successful pregnancies. Moreover, FF adiponectin had a negative correlation with serum LH at Phase III in success subjects. In the KGN cell study, adiponectin had no effects on FSHR and CYP19A1 (aromatase) mRNA expression compared with control. In conclusion, high adiponectin levels in serum compared to FF might contribute to unsuccessful IVF/ICSI treatment.
circ-104916 is downregulated in gastric cancer and suppresses migration and invasion of gastric cancer cells

: Circular RNAs are a large class of noncoding RNA that have shown huge capabilities as gene regulators. Recent evidence suggest that circular RNAs are associated with many dis-eases, especially cancer. However, little attention has been focused on the expression and function of circular RNA in gastric cancer (GC). In this study, we demonstrate that the expression of circ-104916 is downregulated in GC tissues and cell lines. A lower expression of circ-104916 appeared in deeper invasion depth, higher tumor stage and more frequent lymphatic metastasis patients. Overexpression of circ-104916 effectively inhibited the proliferation, migration and invasion abilities of GC cells in vitro. Western blot showed that circ-104916 overexpression upregulated E-cadherin and downregulated N-cadherin, Vimentin and Slug, indicating that circ-104916 was involved in the epithelial–mesenchymal transition process. Our results revealed that circ-104916 might be a novel potential tumor suppressor and biomarker of GC. study, via microarray, we found that the expression of circ-104916 was reduced in GC. 14 In this study, we found that circ-104916 was significantly
Dissecting Myocardial Mechanics in Patients With Severe Aortic Stenosis: 2-Dimensional vs 3-Dimensional–Speckle Tracking Echocardiography

Background: Aortic valve stenosis (AS) commonly causes left ventricular (LV) pressure overload; thus, identifying patients with adverse remodeling/early LV dysfunction is critical. We compared 2-dimensional (2D) to 3-dimensional (3D) echocardiographic measures of LV myocardial deformation in patients with severe AS and studied the relation of LV preload and afterload (Zva) to myocardial deformation. Methods: We prospectively included 168 symptomatic patients (72±12 years) with severe AS and ejection fractions ≥50%. Strain parameters from those patients were compared with normal values found in the literature. 3D full-volume and 2D images were analyzed for global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS), systolic strain rate (SRs), basal rotation (Rotmax-B), apical rotation (Rotmax-A), and peak systolic twist (Twistmax). Results: 2D–GLS and 2D–GCS decreased significantly compared with normal values (P˂.001 and P=.02, respectively); 2D Rotmax-B and Twistmax increased (P˂.001 vs normal values). Agreement between 2D–GLS and 3D–GLS by concordance correlation coefficient was 0.49 (95% CI, 0.39-0.57) in patients with AS. Both 2D– and 3D–GLS correlated with valvulo-arterial impedance (Zva) (r=0.34, P<.001; and r=0.23, P=.003, respectively). Conclusion: In patients with severe AS, GLS and GCS decreased, and basal rotation and twist increased to maintain LV ejection fraction. 2D– and 3D–GLS had a relatively fair agreement. Both 2D– and 3D–GLS correlated modestly with Zva.
DeepIso: A Deep Learning Model for Peptide Feature Detection

Liquid chromatography with tandem mass spectrometry (LC-MS/MS) based proteomics is a well-established research field with major applications such as identification of disease biomarkers, drug discovery, drug design and development. In proteomics, protein identification and quantification is a fundamental task, which is done by first enzymatically digesting it into peptides, and then analyzing peptides by LC-MS/MS instruments. The peptide feature detection and quantification from an LC-MS map is the first step in typical analysis workflows. In this paper we propose a novel deep learning based model, DeepIso, that uses Convolutional Neural Networks (CNNs) to scan an LC-MS map to detect peptide features and estimate their abundance. Existing tools are often designed with limited engineered features based on domain knowledge, and depend on pretrained parameters which are hardly updated despite huge amount of new coming proteomic data. Our proposed model, on the other hand, is capable of learning multiple levels of representation of high dimensional data through its many layers of neurons and continuously evolving with newly acquired data. To evaluate our proposed model, we use an antibody dataset including a heavy and a light chain, each digested by Asp-N, Chymotrypsin, Trypsin, thus giving six LC-MS maps for the experiment. Our model achieves 93.21% sensitivity with specificity of 99.44% on this dataset. Our results demonstrate that novel deep learning tools are desirable to advance the state-of-the-art in protein identification and quantification.
CONTROLLING BLOOD PRESSURE IN SEVER HYPERTENSION DURING LABOUR: A COMPARATIVE STUDY.

Background: Pregnancy induced hypertension with proteinuria occur in 5% of primigravidas, it remains the commonest cause of maternal mortality and substantial cause of neonatal morbidity and mortality. Pre-eclampsia is complex & still incompletely understood. Patients and methods: This prospective study had been conducted in a maternity hospital in Baghdad, between November 1993 and September 1994.Fifty women with antepartum or intrapartum diagnosis of severe pre-eclampsia were invited to participate on voluntary base in this study. Those 50 cases divided randomly into two equal groups the first group treated by nefipidine and the second group was given hydralazine. Results: The first group was put on Nifedipine Both drugs are efficient in
The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model.

BACKGROUND & AIMS The recently proposed Inflammatory Reflex describes an interaction between the vagus nerve and peripheral macrophages, resulting in attenuation of proinflammatory cytokine release in response to systemic exposure to bacterial endotoxin. The purpose of this study was to determine whether a similar vagus/macrophage axis modulates the inflammatory responses in the colon in mice. METHODS We assessed the Disease Activity Index (DAI), macroscopic and histologic damage, serum amyloid-P level, and myeloperoxidase activity in colitis induced by administration of dextran sodium sulfate (DSS) in healthy and vagotomized C57BL/6 and in mice deficient in macrophage-colony stimulating factor (M-CSF)-induced and in hapten-induced colitis. A pyloroplasty was performed in vagotomized mice. RESULTS DAI, macroscopic and histologic scores, myeloperoxidase activity, levels of serum amyloid-P, and colonic tissue levels of interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha were increased significantly in vagotomized mice 5 days post-DSS and 3 days after hapten-induced colitis compared with sham-operated mice that received DSS or the hapten. Pretreatment with nicotine significantly decreased each of these markers in vagotomized mice with DSS colitis, and all markers except DAI and IL-6 in sham-operated DSS-treated mice. Conversely, hexamethonium treatment significantly increased each of these markers in the sham-operated DSS-treated mice. Vagotomy had no effect on the colitis in M-CSF-deficient mice. CONCLUSIONS The vagus nerve plays a counterinflammatory role in acute colitis via a macrophage-dependent mechanism, involving hexamethonium-sensitive nicotinic receptors. The identification of a counterinflammatory neural pathway would open new therapeutic avenues for treating acute exacerbations of inflammatory bowel disease.
Novel insights into the complexity of ischaemic heart disease derived from combined coronary pressure and flow velocity measurements

This thesis concerns the complexity of ischaemic heart disease, and the crucial role of the coronary microcirculation in its diagnosis and prognosis. After five decades of a stenosis-centered approach towards both its diagnosis and treatment, it is increasingly acknowledged that ischaemic heart disease is a complex disease that involves multiple levels of the coronary circulation, including both the epicardial and microvascular domains of the coronary circulation, as well as the myocardium. This multi-level origin of ischaemic heart disease has important implications for routine physiology-guided strategies applied in contemporary clinical practice, as is discussed in Part A of this thesis. Despite a well-documented benefit of physiology-guided coronary revascularization compared with angiographic guidance, its application in clinical practice remains limited. This has governed attempts to optimize the applicability of coronary physiology techniques in clinical practice by circumventing part of the practical ambiguities associated with physiological testing. One of such approaches, circumventing the need for pharmacological vasodilation, is discussed in Part B of this thesis. Finally, the acknowledgement of the coronary microcirculation as an important prognostic component in ischaemic heart disease has governed attempts to identify the magnitude of its prognostic value, as well as to design novel therapeutic strategies that specifically address the coronary microcirculation, which is discussed in Part C of this thesis.
Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: a WHO-coordinated, prospective, international, observational cohort study

Kleinschmidt, Immo; Bradley, John; Knox, Tessa Bellamy; Mnzava, Abraham Peter; Kafy, Hmooda Toto; Mbogo, Charles; Ismail, Bashir Adam; Bigoga, Jude D; Adechoubou, Alioun; Raghavendra, Kamaraju; +29 more. Cook, Jackie; Malik, Elfatih M; Nkuni, Zinga José; Macdonald, Michael; Bayoh, Nabie; Ochomo, Eric; Fondjo, Etienne; Awono-Ambene, Herman Parfait; Etang, Josiane; Akogbeto, Martin; Bhatt, Rajendra M; Chourasia, Mehul Kumar; Swain, Dipak K; Kinyari, Teresa; Subramaniam, Krishanthi; Massougbodji, Achille; Okê-Sopoh, Mariam; Ogouyemi-Hounto, Aurore; Kouambeng, Celestin; Abdin, Mujahid Sheikhedin; West, Philippa; Elmardi, Khalid; Cornelie, Sylvie; Corbel, Vincent; Valecha, Neena; Mathenge, Evan; Kamau, Luna; Lines, Jonathan; Donnelly, Martin James; (2018) Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: a WHO-coordinated, prospective, international, observational cohort study. The Lancet infectious diseases, 18 (6). pp. 640-649. ISSN 1473-3099 DOI: https://doi.org/10.1016/S14733099(18)30172-5