Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of initial energy reserves in stress tolerance thresholds during the early benthic phase in intertidal invertebrates

: Although depleted energy reserves are not a major direct cause of early benthic phase mortality for many species of marine invertebrates, initial energy reserves might nevertheless play a role in early benthic phase mortality through indirect effects on physiological tolerance thresholds, a mechanism that has not been tested. We therefore examined the extent to which energy reserves affect acute tolerance thresholds of early benthic phase individuals of 2 species ( Balanus glandula and Nucella ostrina ) to 2 of the most challenging intertidal stressors: desiccation and high emersion temperature. Energy reserve levels were estimated by maintaining individuals without food for different durations of time or using individuals of different body mass. Individuals in each energy level treatment were then exposed to a range of desiccation periods and emersion temperatures. Lower estimated energy levels had no effect on tolerance to emersion temperature, but did significantly reduce the ability to tolerate desiccation. This suggests the survival of individuals through the early benthic phase is likely dependent on initial energy content through an indirect effect on tolerance to de -siccation. Also, habitats experiencing intense desiccation likely impose a selective pressure on intertidal invertebrates favoring the evolution of greater energy reserves at the onset of the early benthic phase. These findings suggest depleted energy reserves at the onset of the early benthic phase can influence early benthic phase mortality through indirect effects by making individuals more vulnerable to environmental stressors. In this way, energy reserves may impact re cruitment rates and thus influence population dynam-ics and intertidal community structure.
Optimization of Collection Tree Protocol

: Collection tree protocol is a tree based protocol which is mainly used for aggregation. It is minimum cost routing tree which selects the path having minimum cost routing gradient. It will generate one or more trees to root which is called base station. When any node has data it sends data up the tree which is forwarded to root.CTP will provide link quality estimation among nearby neighbours. It will indicate number of transmissions from a node to send a packet to destination and whose acknowledgment is successfully received. It sends data to root by choosing a next hop. CTP is having a problem of fast energy depletion which is caused by congestion in the network. Also energy level of the network is not highly scalable. Whenever a node in a network is failed it is not able to do the function and it should not effect on overall network. When more number of nodes are added in the network, congestion will take place and so it does not have an additional energy to choose an optimal path. In revised CTP, to enhance the energy level of a network RSSI is used in broadcast fault tolerant algorithm. RSSI means power received by antenna. CTP suffers a problem by disseminating data statically in network. So in revised CTP line mobility model is integrated which will send data dynamically to sink node.
Simulation Comparisons and Implementation of Wind Power Based Induction Generator

This paper describes the performance comparison of a wind power systems based on two differentinduction generators as well as the experimental demonstration of a wind turbine simulator for the maximumpower extraction. The two induction machines studied for the comparison are the squirrel-cage inductiongenerator (SCIG) and the doubly fed induction generator (DFIG). The techniques of direct grid integration, independent power control, and the droop phenomenon of distribution line are studied andcompared between the SCIG and DFIG systems. Both systems are modeled in Matlab/Simulink environment, and the operation is testedfor the wind turbine maximum power extraction algorithm results. Based on the simulated wind turbine parameters, a commercialinduction motor drive was programmed to emulate the wind turbine and is coupled to the experimental generator systems. The turbineexperimental results matched well with the theoretical turbine operation.
Edinburgh Research Explorer Synergy and Group Size in Microbial Cooperation

Microbes produce many molecules that are important for their growth and development, and the consumption of these secretions by nonproducers has recently become an important paradigm in microbial social evolution. Though the production of these public goods molecules has been studied intensely, little is known of how the benefits accrued and costs incurred depend on the quantity of public good molecules produced. We focus here on the relationship between the shape of the benefit curve and cellular density with a model assuming three types of benefit functions: diminishing, accelerating, and sigmoidal (accelerating then diminishing). We classify the latter two as being synergistic and argue that sigmoidal curves are common in microbial systems. Synergistic benefit curves interact with group sizes to give very different expected evolutionary dynamics. In particular, we show that whether or not and to what extent microbes evolve to produce public goods depends strongly on group size. We show that synergy can create an “evolutionary trap” which can stymie the establishment and maintenance of cooperation. By allowing density dependent regulation of production (quorum sensing), we show how this trap may be avoided. We discuss the implications of our results for experimental design.
The application of artificial gravity in medicine and space

Gravity plays a crucial role in physiology. The lack of gravity, like in long duration spaceflight missions, cause pathologies in e.g., the musculoskeletal system, cardiovascular deconditioning, immune system deprivation or brain abnormalities, to just mention a few. The application of artificial gravity through short-arm human centrifugation (SAHC) has been studied as a possible countermeasure to treat spaceflight deconditioning. However, hypergravity protocols applied by using SAHC have also been used to treat different, ground-based pathologies. Such gravitational therapies have been applied in Uruguay for more than four decades now. The aim of this overview is to summarize the most important findings about the effects of gravitational therapy in different, mainly vascular based pathologies according to the experience in the Gravitational Therapy Center and to discuss the current research in the field of hypergravity applications in medicine but also as multisystem countermeasure for near weightlessness pathologies. New insight is needed on the use of hypergravity in medicine and space research and application.
Trial of a prehospital intervention with traditional Chinese medicine for acute stroke (TRACE): Protocol for a mixed-methods research study

Background: As the only traditional Chinese medicine injection approved by the China Food and Drug Administration for use as stroke first aid in ambulances, Xingnaojing Injection (XNJI) has been widely used in cases of both acute ischemic stroke (IS) and intracerebral hemorrhage (ICH). However, there is no robust clinical evidence regarding the efficacy and safety of the early use of XNJI during stroke first aid. The main purpose of this trial is to observe whether XNJI, intravenously administered within 24 h of onset in the prehospital ambulance setting, protects against early neurological deterioration (END) on the third day of onset in patients with acute stroke. Methods: The Trial of a prehospital intervention with traditional Chinese medicine for acute stroke (TRACE) is a Mixed-Methods research (MMR) study that involves a combination of quantitative and qualitative research. The quantitative research part of this project is a prospective, multicenter, observational, clinical registry study, for which we aimed to recruit 1,000 patients with acute stroke (IS and ICH). Based on our observation of whether XNJI was intravenously administered within 24 h of onset in the prehospital ambulance setting, patients with acute stroke will be divided into two groups: the exposure group comprising patients who were intravenously administered XNJI and the nonexposure group comprising patients who were not. The primary outcome is early neurological deterioration (END) on the third day of onset defined as an increase of 2 or more points in the National Institute of Health Stroke Scale score between baseline and day 3. In addition, based on the aforementioned quantitative research, qualitative research will be conducted by interviewing emergency doctors about their knowledge and attitude regarding XNJI used for stroke first aid. Discussion: The results of the TRACE study will provide preliminary evidence for the relationship between XNJI used within 24 h of onset and the presence of END on the third day after stroke onset; it will aid in improving the current knowledge regarding the early use of XNJI for stroke first aid. Clinical Trial Registration: clinicaltrials.gov, identifier NCT04275349
The phenotype of the gut region is more stably retained than developmental stage in piglet intestinal organoids

Intestinal organoids are innovative in vitro tools to study the digestive epithelium. The objective of this study was to generate jejunum and colon organoids from suckling and weaned piglets in order to determine the extent to which organoids retain a location-specific and a developmental stage-specific phenotype. Organoids were studied at three time points by gene expression profiling for comparison with the transcriptomic patterns observed in crypts in vivo. In addition, the gut microbiota and the metabolome were analyzed to characterize the luminal environment of epithelial cells at the origin of organoids. The location-specific expression of 60 genes differentially expressed between jejunum and colon crypts from suckling piglets was partially retained (48%) in the derived organoids at all time point. The regional expression of these genes was independent of luminal signals since the major differences in microbiota and metabolome observed in vivo between the jejunum and the colon were not reproduced in vitro. In contrast, the regional expression of other genes was erased in organoids. Moreover, the developmental stage-specific expression of 30 genes differentially expressed between the jejunum crypts of suckling and weaned piglets was not stably retained in the derived organoids. Differentiation of organoids was necessary to observe the regional expression of certain genes while it was not sufficient to reproduce developmental stage-specific expression patterns. In conclusion, piglet intestinal organoids retained a location-specific phenotype while the characteristics of developmental stage were erased in vitro. Reproducing more closely the luminal environment might help to increase the physiological relevance of intestinal organoids.
Study on plasma metabolomics for HIV/AIDS patients treated by HAART based on LC/MS-MS

Background: Metabolomics can be applied to the clinical diagnosis and treatment evaluation of acquired immune deficiency syndrome (AIDS). AIDS biomarkers have become a new direction of AIDS research providing clinical guidance for diagnosis. Objective: We sought to apply both untargeted and targeted metabolomic profiling to identify potential biomarkers for AIDS patients. Methods: A liquid chromatography-tandem mass spectrometry (LC-MS/MS) based untargeted metabolomic profiling was performed on plasma samples of patients before and after highly active antiretroviral therapy (HAART) treatment as well as healthy volunteers to identify potential AIDS biomarkers. Targeted quantitative analysis was performed on the potential biomarkers screened from untargeted metabolic profiling for verification. Results: Using the Mass Profiler Professional and the MassHunter, several potential biomarkers have been found by LC-MS/MS in the untargeted metabolomic study. High-resolution MS and MS/MS were used to analyze fragmentation rules of the metabolites, with comparisons of related standards. Several potential biomarkers have been identified, including PS(O-18:0/0:0), sphingosine, PE (21:0/0:0), and 1-Linoleoyl Glycerol. Targeted quantitative analysis showed that sphingosine and 1-Linoleoyl Glycerol might be closely related to HIV/AIDS, which may be the potential biomarkers to the diagnosis. Conclusion: We conducted untargeted metabolomic profiling, which indicates that several metabolites should be considered potential biomarkers for AIDS patients. Further targeted metabolomic research verified that d-Sphingosine and 1-Linoleoyl glycerol as the diagnostic biomarker of AIDS.
The role of tumor-associated macrophages in oral squamous cell carcinoma

Oral squamous cell carcinoma (OSCC) is a common head and neck cancer with a high recurrence rate and a low 5-year survival rate. Tumor-associated macrophages (TAMs) are important immune cells in the tumor microenvironment, which play an important role in the progression of many tumors. This article reviews the origin, and the role of TAMs in the invasion, metastasis, angiogenesis and immunosuppression of OSCC. Therapeutic strategies targeting TAMs are also discussed in hopes of providing new ideas for the treatment of OSCC.
Ab initio theory of spin entanglement in atoms and molecules

We investigate spin entanglement in many-electron systems within the framework of density functional theory. We show that the entanglement length, which is extracted from the spatial dependence of the local concurrence, is a sensitive indicator of atomic shells and reveals the character, covalent or metallic, of chemical bonds. These findings shed light on the remarkable success of modern density functionals, which tacitly employ the entanglement length as a variable. This opens the way to further research on entanglement-based functionals.
Olbert’s Balloon Dilatation as a Minimally Invasive Possibility of Treating Ureteral Stricture After Complicated URS-L in Children

Olbert’s balloon dilatation is a surgical technique used for the treatment of ureteral stricture. Although it is more frequently used in adults, due to the advancing miniaturization of the equipment, this technique has become possible in children. We would like to present five cases of Olbert’s balloon dilatation carried out in children with ureteral stricture, aged 12–17 years. All of these children were diagnosed for at least 6 months. Ureteral stricture has been noticed in those patients with a time of a stone residence in the ureter longer than 6 months. The duration of the stone in the ureter varied from 6 to 18 months. The symptoms were abdominal pain, renal colic pain, UTI, fever, vomiting, and nausea. Ultrasound (US) revealed hydronephrosis and ureter dilatation above the stone. All of these children had grade-3 hydronephrosis based on the Onen grading system during admission to the hospital. The lack of renal function on the DMSA scan was observed with an average of 22%. JJ-stent was inserted as a first-line treatment. A retrograde pyelogram revealed ureteral stricture at a length from 1 to 1.7 cm in the place where the stone was ingrown. Olbert’s balloon dilatation under fluoroscopy was performed successfully in all children. We achieved an efficacy of 60% in our series. Renal function increased to an average of 36% on DMSA 3 months after surgery. The level of creatinine is shaped at an average of 0.6. On US, two children had no hydronephrosis while one child had grade-1 hydronephrosis. The longest follow-up is now 4 years, with the same good results. In conclusion, Olbert’s balloon dilatation is an effective, safe, and minimally invasive tool for ureteral stricture in the hands of the endourological experienced pediatric urologist. But more prospective, randomized trials are still needed.
Disrupting reconsolidation by PKA inhibitor in BLA reduces heroin-seeking behavior

Drug abuse is considered a maladaptive pathology of emotional memory and is associated with craving and relapse induced by drug-associated stimuli or drugs. Reconsolidation is an independent memory process with a strict time window followed by the reactivation of drug-associated stimulus depending on the basolateral amygdala (BLA). Pharmacology or behavior treatment that disrupts the reconsolidation can effectively attenuate drug-seeking in addicts. Here, we hypothesized that heroin-memory reconsolidation requires cAMP-dependent protein kinase A (PKA) of BLA based on the fundamental effect of PKA in synaptic plasticity and memory process. After 10 days of acquisition, the rats underwent 11 days of extinction training and then received the intra-BLA infusions of the PKA inhibitor Rp-cAMPS at different time windows with/without a reactivation session. The results show that PKA inhibitor treatment in the reconsolidation time window disrupts the reconsolidation and consequently reduces cue-induced reinstatement, heroin-induced reinstatement, and spontaneous recovery of heroin-seeking behavior in the rats. In contrast, there was no effect on cue-induced reinstatement in the intra-BLA infusion of PKA inhibitor 6 h after reactivation or without reactivation. These data suggest that PKA inhibition disrupts the reconsolidation of heroin-associated memory, reduces subsequent drug seeking, and prevents relapse, which is retrieval-dependent, time-limited, and BLA-dependent.
Comparison of techno-functional and sensory properties of sponge cakes made with egg powder and different quality of powdered blood products for substituting egg allergen and developing functional food

Animal blood is a valuable resource, which is usually not utilized in a value-added way by the industry like other animal by-products, even though it has plenty of benefits in terms of sustainability and human health, particularly against iron deficiency anemia. Animal blood is perfectly suitable for providing special functions, which are necessary for functional foods, and improving techno-functional properties based on the previous reports published in the literature. In this paper, egg powder was substituted by powdered animal blood products (whole blood powder, blood plasma powder, and hemoglobin powder) in sponge cake. Techno-functional and sensory properties (texture by texture profile analysis and three-point breaking test, water activity, dry matter content, and color) were instrumentally measured and then a sensory evaluation was carried out by unskilled panelists. Quality characteristics (texture, color, and dry matter content) were daily measured on the day of baking and then every 24 h for 3 additional days because freshly baked cakes are usually consumed within 3 days. Based on the results, powdered blood products are suitable for substituting the egg powder in sponge cakes and developing functional foods. Blood powders can increase the hardness, chewiness, and breaking force of cakes, giving them the ability to be stuffed with more fillings and molded into special shapes without compromising on the sensory characteristics. They can also increase the intensity of the cocoa flavor, which results in a richer, darker color without deceiving the consumers.
The ventral striatum contributes to the activity of the motor cortex and motor outputs in monkeys

The ventral striatum (VSt) is thought to be involved in the vigor of motivated behavior and is suggested to be a limbic-motor interface between limbic areas involved in motivational processes and neural circuits regulating behavioral outputs. However, there is little direct evidence demonstrating the involvement of the VSt in motor control for motivated behaviors. To clarify the functional role of the VSt in motor control, we investigated the effect of reversible pharmacological inactivation of the VSt on the oscillatory activity of the sensorimotor cortices and motor outputs in two macaque monkeys. VSt inactivation reduced movement-related activities of the primary motor cortex and premotor area at 15–120 Hz and increased those at 5–7 Hz. These changes were accompanied by reduced torque outputs but had no effect on the correct performance rate. The present study provides direct evidence that the VSt regulates activities of the motor cortices and motor output.
Effect of social media overload on college students’ academic performance under the COVID-19 quarantine

Features and relevant services of online social media have been attracting users during the COVID-19 pandemic. Previous studies have shown that college students tend to use social media more frequently than other groups. However, in being affected by social media overload, the social media use behaviors of many college students have been out of their control in terms of their capabilities or cognition. Based on the stressor–strain–outcome (SSO) model and the theory of compensatory internet use (TCIU), we developed a research model to study the causes of social media overload and its impact on college students’ academic performance during the COVID-19 pandemic. A total of 441 valid responses from college students through questionnaires in China are collected via purposive sampling and used in the data analysis. This study conducts PLS-SEM to analyze collected data, finding that boredom proneness is associated with overload (stress), which has a bearing on social media overload (strain) and the reduction in final performance (outcome). Through illustrating the psychological and behavioral conditions that hinder the academic performance of students, this study provides deeper insights into students’ uncontrollable use of social media. Moreover, with respect to the identified antecedents, this study aims to find solutions to mitigate the impact of social media overload resulting from boredom proneness on the academic performance of college students.