Miracle-dz/UniFAR-FTUs huggingface dataset:
Unravelling the instability of mutational signatures extraction via archetypal analysis

The high cosine similarity between some single-base substitution mutational signatures and their characteristic flat profiles could suggest the presence of overfitting and mathematical artefacts. The newest version (v3.3) of the signature database available in the Catalogue Of Somatic Mutations In Cancer (COSMIC) provides a collection of 79 mutational signatures, which has more than doubled with respect to previous version (30 profiles available in COSMIC signatures v2), making more critical the associations between signatures and specific mutagenic processes. This study both provides a systematic assessment of the de novo extraction task through simulation scenarios based on the latest version of the COSMIC signatures and highlights, through a novel approach using archetypal analysis, which COSMIC signatures are redundant and more likely to be considered as mathematical artefacts. 29 archetypes were able to reconstruct the profile of all the COSMIC signatures with cosine similarity > 0.8. Interestingly, these archetypes tend to group similar original signatures sharing either the same aetiology or similar biological processes. We believe that these findings will be useful to encourage the development of new de novo extraction methods avoiding the redundancy of information among the signatures while preserving the biological interpretation.
The relationship between social support and Internet addiction among Chinese college freshmen: A mediated moderation model

Purpose Internet addiction has become a worldwide mental health problem, and this problem is particularly prominent in China. Although current studies have shown that social support is closely related to Internet addiction, the mechanism of the relationship between the two is not clear at present. This study aimed to find out the influencing factors and the mechanism of Internet addiction among college freshmen, and to form scientific prevention and intervention plan on this basis. Method This study adopts the cluster sampling method to select 322 college freshmen in a typical postsecondary school in Shandong Province, using Chinese Internet Addiction Scale (CIAS), Social Support Rating Scale (SSRS), and Network-related Maladaptive Cognition Scale (NRMCS) to investigate the relationship between social support, network-related maladaptive cognition, gender, and the degree of Internet addiction. Results The findings of this study are as follows: (1) After controlling age and family location, social support had a significant negative predictive effect on Internet addiction; (2) Gender acted as a moderator between the relationship of social support and Internet addiction; and (3) Additionally, the moderating effect of gender was completely mediated by network-related maladaptive cognition. Conclusion There is a mediated moderating effect between social support and Internet addiction. That is, gender plays a moderating role between social support and Internet addiction, and this moderating effect is mediated by network maladaptive cognition.
A bibliometric study on Marburg virus research with prevention and control strategies

Marburg virus (MARV) is a pathogenic zoonotic RNA virus etiologic for Marburg virus disease (MVD), a severe hemorrhagic fever. This is a rare disease, with a high fatality rate, that spreads via infected blood or body fluids or indirectly via fomites (contaminated objects and substances such as clothed, beds, personal protective equipment, or medical equipments). A few vaccines to protect against MARV are undergoing clinical trials, but there is not yet an approved vaccine against this disease. Eventually, prevention and control guidelines should be adhered to rigorously to alleviate this infection. This bibliometric analysis aimed to harness narrative evaluation, emphasizing the significance of quantitative approaches and delineating the most thought-provoking concerns for researchers using VOSviewer software (Centre for Science and Technology Studies, Leiden University, the Netherlands). “Marburg Virus” OR “MARV” AND “Diseases” search criteria were used for the analysis of articles published between 1962 and 2022. Co-occurrence analysis was carried out, which characterized different thematic clusters. From this analysis, we found that 1688 published articles, and the number of publications increased across that period annually, with a growth rate of 8.78%. It is also conspicuous that the number of publications in the United States reached its acme during this period (i.e., 714 publications, accounting for 42.29% of the total), and the United States Army Medical Research Institute of Infectious Diseases published the most literature (i.e., 146 papers). Our study found that the three pre-eminent authors of Marburg virus papers were “FELDMANN, HEINZ“ of the National Institute of Allergy and Infectious Diseases, United States, “BECKER, STEPHAN” of the Philipps University of Marburg, Germany, and “GEISBERT, THOMAS W” of the University of Texas Medical Branch, United States. In this study we found that “JOURNAL OF VIROLOGY” has published the most pertinent literature, totaling 88 articles, followed by “The journal of Infectious Diseases”, which published 76 relevant papers, and “VIRUSES”, which published 52 corresponding papers. The most cited paper on the Marburg virus was published in Nature Medicine, with 522 total citations and 29 citations/year. Studies of the changing epidemiology and evolving nature of the virus and its ecological niche are required; breakthrough and implementation of the efficacious vaccine candidate(s), prophylaxis and therapeutic alternatives and supervision strategies, unveiling awareness-raising programs, and developing apposite and timely preparedness, prevention, and proactive control strategies are of utmost importance.
Interfacial intermetallic compound modification to extend the electromigration lifetime of copper pillar joints

Electromigration is the massive metal atom transport due to electron flow, which could induce a disconnect in electronics. Due to the size of copper pillar bump reduction, the portion of interfacial intermetallic compound in solder joints is increasing obviously. However, there is lack of systematical research on the effects of intermetallic compound on the EM lifetime of solder joints. In this paper, the interfacial intermetallic compound of copper pillar joints is modified to extend the electromigration lifetime. The growth rate of intermetallic compound in solder joints sample is calculated firstly. From 230°C to 250°C, the growth rate of intermetallic compound increases from 0.09 μm/min to 0.19 μm/min. With a longer reaction time, the intermetallic compound layers continuously grow. Then electromigration tests were conducted under thermo-electric coupling loading of 100°C and 1.0 × 104 A/cm2. Compared with lifetime of thin and thick intermetallic compound samples, the lifetime of all intermetallic compound sample improved significantly. The lifetime of thin, thick, and all intermetallic compound samples is 400 min, 300 min, and 1,200 min, respectively. The failure mechanism for the thin intermetallic compound sample is massive voids generation and aggregation at the interface between solder joints and pads. For the thick intermetallic compound sample, the intermetallic compound distance is short between cathode and anode in solder joints, leading to lots of crack create in the middle of solder joints. As the all intermetallic compound sample can greatly reduce the number of voids generated by crystal structure transforming, the lifetime extend obviously.
Genetic polymorphisms of Ca2+ transport proteins and molecular chaperones in mitochondria-associated endoplasmic reticulum membrane and non-alcoholic fatty liver disease

Background Non-alcoholic fatty liver disease (NAFLD) is recognized to be closely associated with endoplasmic reticulum stress and mitochondrial dysfunction, while previous studies have emphasized the important role of calcium homeostasis from the mitochondria-associated endoplasmic reticulum membrane (MAM) in the endoplasmic reticulum and mitochondria. This article will assess the association between genetic polymorphisms of Ca2+ transport proteins and molecular chaperones in MAM and NAFLD risk. Methods A case-control study was conducted in a community of Nanjing, China during April to December 2020. 2701 subjects were enrolled and genotyped for 6 genetic variants in HSPA5 and ITPR2 genes. Logistic regression analysis was used to assess impact of these variants on NAFLD risk. Results After adjusting for age, gender, total cholesterol and glucose, we identified that HSPA5 rs12009 variant genotypes (recessive model: OR= 0.801, 95% CI= 0.652-0.986, P= 0.036), rs430397 variant genotypes (recessive model: OR= 0.546, 95% CI= 0.314-0.950, P= 0.032), and ITPR2 rs11048570 variant genotypes (recessive model: OR= 0.673, 95% CI= 0.453-0.999, P= 0.049) were associated with a reduced risk of NAFLD. Multivariate stepwise regression analysis indicated that gender, glucose, body mass index, triglycerides and favorable alleles were independent influencers of NAFLD (all P< 0.05). The area under the receiver operating characteristic curve was 0.764 (95% CI= 0.745-0.783, P< 0.001). Conclusion The variant genotypes of Ca2+ transport-associated genes HSPA5 (rs12009 and rs430397) and ITPR2 (rs11048570) might contribute to the reduction of the NAFLD risk in Chinese Han population, which can provide new insight into NAFLD pathogenesis.
Solution of a Two-Dimensional Cochlea Model Using Transform Techniques

We study the propagation of waves on the basilar membrane, a thin elastic plate immersed in the fluid-filled inner ear, using a two-dimensional linear model. Since the basilar membrane has an exponentially increasing compliance, Fourier transforming these equations gives rise to an unusual boundaryvalue problem for an analytic function in the complex plane. We describe a general technique for solving such equations and apply it to the cochlea model. The resulting expression for the Fourier transform can be used to deduce important features of the cochlea wave. This approach also serves as the basis for an efficient numerical method to approximate the cochlea wave using fast Fourier transforms.
Phytochemical composition, antimicrobial activities, and cholinesterase inhibitory properties of the lichen Usnea diffracta Vain

Lichens are important sources of versatile bioactive compounds. Two new dibenzofurans (1–2), a multi-substituted single benzene ring (3), and two organic acid compounds (4–5) along with 25 known compounds (6–30) were isolated from the lichen Usnea diffracta Vain. Their structures were identified by physicochemical properties and spectral analyses. Compounds 1–30 were tested for inhibitory activities against Staphylococcus aureus, Escherichia coli, and Candida albicans by the disk diffusion method and microdilution assay respectively. Compound 3 showed moderate inhibitory activities against S. aureus and E. coli with the inhibition zone (IZ) of 6.2 mm and 6.3 mm, respectively. Depside 10 exhibited good activity against S.aureus and C. albicans with 6.6 mm and 32 μg/ml, respectively. The acetylcholinesterase inhibitory activities of compounds 1, 2, and 6–8 with the characteristic dibenzofuran scaffold were evaluated var anti-AChE assay and a molecular docking study. Compound 2 could better inhibit AChE at the concentration of 0.3 μmol/ml with a value of 61.07 ± 0.85%. The molecular docking study also demonstrated that compound 2 had the strongest binding affinity among the five dibenzofurans, and the “-CDOCKER Energy” value was 14.4513 kcal/mol.
Effectiveness of active occupational therapy in patients with acute stroke: A propensity score-weighted retrospective study

Background and purpose The effects of therapy and patient characteristics on rehabilitation outcomes in patients with acute stroke are unclear. We investigated the effects of intensive occupational therapy (OT) on patients with acute stroke. Methods We performed a retrospective cohort study using the 2005–2016 Japan Rehabilitation Database, from which we identified patients with stroke (n = 10,270) who were admitted to acute care hospitals (n = 37). We defined active OT (AOT) and non-AOT as OT intervention times (total intervention time/length of hospital stay) longer or shorter than the daily physical therapy intervention time, respectively. The outcomes assessed were the Functional Independence Measure (FIM) and National Institutes of Health Stroke Scale (NIHSS) scores, duration of hospitalization, and rate of discharge. Propensity scores and inverse probability of treatment weighting analyses adjusted for patient characteristics were performed to investigate the effects of AOT on patient outcomes. Results We enrolled 3,501 patients (1,938 and 1,563 patients in the AOT and non-AOT groups, respectively) in the study. After inverse probability of treatment weighting, the AOT group had a shorter length of hospitalization (95% confidence interval: −3.7, −1.3, p < 0.001), and the FIM (95% confidence interval: 2.0, 5.7, p < 0.001) and NIHSS (95% confidence interval; 0.3, 1.1, p < 0.001) scores improved significantly. Subgroup analysis showed that lower NHISS scores for aphasia, gaze, and neglect and lower overall NIHSS and FIM scores on admission led to a greater increase in FIM scores in the AOT group. Conclusions AOT improved the limitations in performing activities of daily living (ADL) and physical function in patients with acute stroke and reduced the length of hospitalization. Additionally, subgroup analysis suggested that the increase in FIM score was greater in patients with severe limitations in performing ADLs and worse cognitive impairment, such as neglect, on admission.
Exploring Coulomb interaction in piezoelectric materials for assisting the laser cooling of solids

Realization of anti-Stokes cooling requires high enough photon extraction efficiency as well as quantum efficiency, making the implementation of this technique extremely difficult for semiconductors. Here, for the first time, we demonstrate that the Coulomb interaction between photogenerated electron-hole pairs in strong piezoelectric materials such as GaN/InGaN quantum wells could assist laser cooling. By comparing to the cavity back-action mechanism, we also explain how this process depends upon laser detuning with respect to bandgap. To demonstrate the advantage of this method even further, we present simulations by using experimentally reported parameters of GaN and In0.15Ga0. 85N, in order to conclude that the net cooling is indeed possible even with current III-nitride growth technology.
Development and installation of the GERDA experiment

The progress in the development of the GERDA (GErmanium Detector Array) experiment is presented. The goal of the experiment is the search for neutrinoless double beta decay of 76Ge with considerable reduction of background in comparison with predecessor experiments. GERDA will operate bare germanium semiconductor detectors (enriched in 76Ge) submerged in high purity liquid argon supplemented by a water shield. The experimental set up is currently under construction in the underground facility of LNGS, Italy. The results of various R&D efforts and the main steps of the GERDA set up design and installation are given as well as several novel methods for background reduction are described.
BNT162b2 COVID-19 vaccination elicited protective robust immune responses in pediatric patients with inborn errors of metabolism

Introduction SARS-CoV-2 infection can lead to a life-threatening acute metabolic decompensation in children with inborn errors of metabolism (IEM), so vaccination is mandatory. However, IEMs can also impair innate or adaptive immunity, and the impact of these immune system alterations on immunogenicity and vaccine efficacy is still unknown. Here, we investigated humoral immune responses to the BNT162b2 mRNA COVID-19 vaccine and clinical outcomes in pediatric IEM patients. Methods Fifteen patients between 12-18 years of age with a confirmed diagnosis of IEM, and received BNT162b2 were enrolled to the study. Patients with an anti-SARS-CoV-2 IgG concentration >50 AU/mL before vaccination were defined as “COVID-19 recovered” whereas patients with undetectable anti-SARS-CoV-2 IgG concentration were defined as “COVID-19 naïve”. Anti-SARS-CoV-2 Immunoglobulin G (IgG) and SARS-CoV-2 neutralizing antibody (nAb) titers were measured to assess humoral immune response. Results Anti-SARS-CoV-2 IgG titers and nAb IH% increased significantly after the first dose. The increase in antibody titers after first and second vaccination remained significant in COVID-19 naïve patients. Complete anti-SARS-CoV-2 IgG seropositivity and nAb IH% positivity was observed in all patients after the second dose. Vaccination appears to be clinically effective in IEM patients, as none of the patients had COVID-19 infection within six months of the last vaccination. Discussion Humoral immune response after two doses of BNT162b2 in pediatric IEM patients was adequate and the immune response was not different from that of healthy individuals.
COVID-19 policies and the arising of debate on twitter

This study focuses on the analysis of contacts and communications on Twitter concerning pandemic policies. The goal is both show mobilization processes rising from the web and detect main actors, themes, and contents within the European context. Through a mixed method procedure, we tried to identify the main themes and most relevant communities, the main users, the most relevant topics and languages, and the underlined meanings and differences related to languages (as proxies of areas). Monitoring the communication on 3 main topics (“no-mask”, “covid-19”, “greenpass”), we noticed the weight of the gap between the government's attempts to communicate information motivating measures geared toward managing the crisis and the perceptions of private users. These perceptions spread through the web with such force the more the emotional, ironic, or polemical plane weighs. In this sense, online communication could be considered a tool for understanding the weight of the interaction between the institutional, social, and private dimensions, with effects on the social construction of identities. Digital communication is becoming an element of this process. The paper describes the “reassuring” role played by the digital community in the construction of ontological forms of security resulting from the construction of a shared digital culture. Results show the emergence of digital communities, structured on reference hubs and standing out from the detected phenomenon, prevalence of idioms and even language structures. The relevant role of the emotional (French), ironic (Italian), protest (English) component is confirmed, but also the changing and fluid structure of the debate and the co-presence of many parallel discussion communities.
Numerical Modeling of 26Al-Induced Radioactive Melting of Asteroids Considering Accretion

We have developed a computer code that solves numerically the 1D heat transport equation for small planetary bodies consisting of silicate material and heated by 26Al. At the same time the bodies' accretion (with a size from 1 km—or smaller—to several hundred kilometers) is taken into account as radial growth. We find that the consideration of accretion is inevitable as it affects the thermal evolution resulting from heating by radioisotopes. Significant changes in thermal behavior are shown to occur in comparison with calculations that assume instantaneous accretion.
St. John's Wort usage in treating of perinatal depression

COPYRIGHT © 2023 Zepeda, Juárez-Portilla and Molina-Jiménez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. St. John’s Wort usage in treating of perinatal depression
Editorial: The molecular mechanisms of experience-dependent plasticity in invertebrates

COPYRIGHT © 2023 Dyakonova, Ito and Giurfa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Editorial: The molecular mechanisms of experience-dependent plasticity in invertebrates
Mass outflow in star formation regions: Cepheus A

The velocity extents, the spatial distributions, and the masses, deduced from CO observations, are very different for the red and blue outflows in Cepheus A. These properties can be modeled by placing the source of outflow amidst an anisotropic density distribution. The red outflow expands in the direction of lower density while the blue outflow encounters greater resistance as it expands toward the density peak in the cloud, as delineated by the NH/sub 3/ emission. The ratio of the masses and the total mass swept up by the outflow can be estimated by a simple model. The observed self-absorption in the line profile is probably due to absorption by the ambient cloud against a hot and optically thick component in the red outlow. We conclude that the appearance of an outflow is strongly affected by the environment in which it is embedded. In particular, the outflow in Cepheus A may not be very well collimated. The general attributes of the model are shown to be applicable to other regions of outflow. The apparently bipolar nature of outflows in star formation regions is discussed.
Editorial: Tracking marine megafauna for conservation and marine spatial planning

COPYRIGHT © 2023 Pereira, Clay, Reisinger, RopertCoudert and Sequeira. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. TYPE Editorial PUBLISHED 04 January 2023 DOI 10.3389/fmars.2022. 1119428