Miracle-dz/UniFAR-FTUs huggingface dataset:
Control System Development using a PID controller Mechanism for Coordinating Vertical and Horizontal Elasticity

The popularity of the cloud computing has been increased exponentially in recent times. The rapid development of cloud computing technologies has lead to a paradigm shift in the way computing resources are provisioned. Huge number of servers are deployed to serve emerging number of end users everyday. Therefore, the complexity arises to maintain the huge workload as well as to provide expected level of services. Web based applications should have to ensure desired level of quality of services despite dynamic and continuous changes of workload. The main focus of this thesis work is to propose a control system which is implemented with a feedback controlling mechanism known as Proportional Integral Derivative (PID) controller with an existing hybrid controller to dynamically allocate the resources for interactive and noninteractive applications. Traditional approaches are used to take elasticity based decisions such as either monitoring the resource usage or just merely based on Quality of Services (QoS) of solely latency based critical applications specially the webservers. Furthermore, our focus also lies on the batch processing software which is different than the traditional latency critical applications.
Sexual Dysfunctions in Women with Posttraumatic Stress Disorder – a Review Article

unzu-reichendes Wissen bezüglich des Zusammenhangs zwi-schen sexuellen Dysfunktionen und traumatischen Er-fahrungen, vor allem sexueller Art. Im folgenden Artikel werden die Phänomenologie und Diagnostik weiblicher sexueller Dysfunktionen vorgestellt und Folgen von sexueller Gewalterfahrung auf die Sexualität, auch im Kontext einer PTBS, näher erläutert. Zudem werden Vor-schläge zur Integration entsprechender Behandlungs-bausteine in die Therapie gemacht.
Menagerie: exploring the audio-visual rhythms of violence through data, gun triggers, and swarms

Inspired by the collective behaviors associated with biological swarms, Menagerie is a kinetic-sound sculpture that mechanically activates the deconstructed automatic riﬂe gun trigger as an autonomous sound object to evoke the repetitive nature of gun-related violence. Using statistics taken from the occurrence of ﬁrearm-related deaths from each U.S. state, ﬁfty custom-fabricated gun triggers are subject to a speciﬁc self-organizing and behavioral algorithm where they align, synchronize, and devolve to reveal the emergent polyrhythms inherent in American patterns of violence. The empty gesture of the unloaded, cold-clicking trigger is emblematic of the listlessness of political action and redress. In this piece, this sound is used as a medium through which the trigger swarm aggregates sonic mass to expose and sonify the timbral density of gun-related violence. This paper presents an overview of the compositional process involved in the design and fabrication of the AR triggers, the programming and control of the self-organizing triggering algorithm, and the aesthetic ramiﬁ-cations of composing for the trigger as a cultural object.
BAR EFFECTS ON CENTRAL STAR FORMATION AND AGN ACTIVITY

Galactic bars are often suspected to be a channel of gas inﬂow to the galactic center and trigger central star formation and active galactic nuclei (AGN) activity. However, the current status on this issue based on empirical studies is unsettling, especially on AGN. We investigate this question based on the Sloan Digital Sky Survey (SDSS) Data Release 7. From the nearby (0 . 01 < z < 0 . 05) bright ( M r < − 19) database, we have constructed a sample of 6,658 relatively face-on late-type galaxies through visual inspection. We found 36% of them to have a bar. Bars are found to be more common in galaxies with earlier morphology. This makes sample selection critical. Parameter-based selections would miss a large fraction of barred galaxies of early morphology. Bar eﬀects on star formation or AGN are diﬃcult to understand properly because multiple factors (bar frequency, stellar mass, black-hole mass, gas contents, etc.) seem to contribute to them in intricate manners. In the hope of breaking these degeneracies, we inspect bar eﬀects for ﬁxed galaxy properties. Bar eﬀects on central star formation seem higher in redder galaxies. Bar eﬀects on AGN on the other hand are higher in bluer and less massive galaxies. These eﬀects seem more pronounced with increasing bar length. We discuss possible implications in terms of gas contents, bar strength, bar evolution, fueling time-scale, and the dynamical role of supermassive black hole.
DR 3.1: Personalized adaptive action selection Y1 Report

Based on the presented results, we demonstrate that the architecture successfully works with several concurrent models and manages to rapidly identify the most accurate one. The results also show that our current implementation of the architecture is able to simultaneously execute several thousands of concurrent simple models per second allowing the system to consider a large number of alternative actions without aﬀecting the system reactiveness, even if the computational complexity of the underlying models increase greatly. These results demonstrate that this action selection architecture has the computational power and eﬃciency required for use in the PAL Project.
A REVIEW ON PARKINSON’S DISEASE

have When ABSTRACT Parkinson‟s disease (PD) is the most common neurodegenerative disorders characterized by a neuronal accumulation of the presynaptic protein synuclein and by variable degrees of parkinsonism, defined as a paucity and slowness of movement (bradykinesia), tremor at rest, rigidity, shuffling gait, and flexed posture. Nearly all forms of parkinsonism result from a reduction of dopaminergic transmission within the basal ganglia. The incidence of PD is between 8 and 18 per 100,000 person in years. Prevalence in India is ab70/100,000 population and this is lower than that reported in the West. Most PD cases occur sporadically and of unknown cause. Twin studies suggest that environmental factors likely play the more important role in patient older than 50 years, with genetic factors being more important in younger patients. In PD dopaminergic and other cells die due to a combination of factors including: Genetic vulnerability, Oxidative stress, Proteosomal dysfunction, Environmental factors. Many risk factors and protective factors have been proposed, sometimes in relation to theories concerning possible mechanisms of the disease. None have been conclusively related to Parkinson‟s disease by empirical evidence. Therapy in PD are to maintain function and quality of life and to avoid drug-induced complications. This is obtained through the use of drugs that either increase dopaminergic actions or diminish neuronal outflow from the striatum.
TCF7L2 SNPs, cardiovascular disease, and all-cause mortality: The Atherosclerosis Risk in Communities (ARIC) Study

Aims and Hypothesis— We hypothesize that transcription factor 7-like 2 (TCF7L2) single nucleotide polymorphisms (SNPs) are associated with cardiovascular disease (CVD) and that the associations differ in diabetic and non-diabetic participants. Methods— Black and white subjects from the Atherosclerosis Risk in Communities (ARIC) study who were free of prevalent CVD at baseline and genotyped for rs7903146, rs12255372, rs7901695, rs11196205, and rs7895340 were included in this analysis (n = 13,369). Cox proportional hazard regression was used to estimate the associations of polymorphisms and incident events and logistic and linear regression were used for associations with baseline risk factor levels. Results— TCF7L2 SNPs were not significantly associated with incident coronary heart disease, ischemic stroke, CVD, prevalent peripheral artery disease (PAD), or with all-cause mortality in the full cohort or stratified by race. Conclusions/Interpretation— In the whole cohort, TCF7L2 SNPs were not associated with incident CVD, all-cause mortality, or prevalent PAD. This result suggests that the increased health risk associated with rs7903146 genotype is specific to diabetes. Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, and N01-HC-55022. The authors thank the staff and participants of the ARIC study for their important contributions.
Consumption after a diet violation: disinhibition or compensation?

— Previous research, restricted to the laboratory, has found that restrained eaters overeat after they violate their diet. However, there has been no evidence showing that this same process occurs outside the lab. We hypothesized that outside of this artiﬁcial setting, restrained eaters would be able to control their eating. In Study 1, 127 participants reported hourly on their diet violations and eating over 2 days. In Study 2, 89 participants tracked their intake for 8 days, and 50 of these participants consumed a milk shake (a diet violation) on Day 7, as part of an ostensibly unrelated study. As hypothesized, dieters did not overeat following violations of their diet in either study. These ﬁndings are in contrast with those of previous lab studies and dispel the widely held belief that diet violations lead to overeating in everyday life.
University of Birmingham Metazoan DNA replication origins

DNA replication starts with the opening of DNA at sites called DNA replication origins. From the single sequence-specific DNA replication origin of the small E. Coli genome, up to the thousands of origins that are necessary to replicate the large human genome, strict sequence specificity has been lost. Nevertheless, genome-wide analyses performed in the recent years, using different mapping methods, demonstrated that there are precise locations along the metazoan genome from which replication initiates. These sites contain relaxed sequence consensus and epigenetic features. There is flexibility in the choice of origins to be used during a given cell cycle, probably imposed by evolution and developmental constraints. Here, we will briefly describe their main features.
University of Birmingham Mass spectrometry based metabolomics comparison of liver grafts from Donors after Circulatory Death (DCD) and Donors after Brain Death (DBD) used in human orthotopic liver transplantation

Use of marginal liver grafts, especially those from donors after circulatory death (DCD), has been considered as a solution to organ shortage. Inferior outcomes have been attributed to donor warm ischaemic damage in these DCD organs. Here we sought to profile the metabolic mechanisms underpinning donor warm ischaemia. Non-targeted Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry metabolomics was applied to biopsies of liver grafts from donors after brain death (DBD; n = 27) and DCD (n = 10), both during static cold storage (T 1 ) as well as post-reperfusion (T 2 ). Furthermore 6 biopsies from DBD donors prior to the organ donation (T 0 ) were also profiled. Considering DBD and DCD together, significant metabolic differences were discovered between T 1 and T 2 (688 peaks) that were primarily related to amino acid metabolism, meanwhile T 0 biopsies grouped together with T 2 , denoting the distinctively different metabolic activity tryptophan (T propose tryptophan/ and as possible biomarkers for the higher graft of livers, and conclude that the associated
NUMERICAL STUDY OF ELASTIC WAVE PROPAGATION IN A LAYERED BAR

: In this paper, we numerically study elastic wave propagation in a heterogeneous bar. Different compositions of the layered bar are assumed as well as number of layers and different materials. The effect of bar composition on stress distribution is analyzed. For numerical simulations, the ﬁnite element method and the ﬁnite volume method are used in the sense of explicit time integration. Numerical computations show the strong inﬂuence of layer compositions on the dispersion of a pulse and stress distribution in a heterogeneous bar. The numerical prediction of stress wave propagation in heterogeneous bars helps for the setting of suitable experimental specimens made by additive technologies for studies of wave propagation in such materials.
Changes in physiological states by swearing in adolescents: a pilot study using heart rate variability and EEG

We investigated the influence of swearing on physiological systems in high school students by measuring heart rate variability (HRV) and electroencephalography (EEG). In total, 15 male students of the first grade in high school were divided into two groups based on their frequency of swearing: highly frequent swearing (HFS, n = 8) and low frequency swearing (LFS, n = 7). They were listened to under three conditions of conversation: every-day conversation without swearing (EC), a conversation consisting of light swearing (LS), and conversation consisting of severe swearing (SS). The results of the HRV analysis were as follows: the HRV of the two groups showed a significant difference in SS conditions in both LF and HF. The LF norm was higher in LFS (HFS: 47.6, LFS: 63.3) and the HF norm was higher in HFS (HFS: 52.4, LFS: 36.7). The LF/HF ratio in the SS condition was significantly different between the groups. (HFS: 1.0, LFS:1.9). The results of the spectrum analysis of the EEG were significantly different in the alpha wave of Fp2 in the EC condition between HFS and LFS, although no significant difference was found in other brain waves under LS and SS conditions. In the severe swearing condition, the LFS group showed higher activity of the sympathetic system and the HFS group showed a higher parasympathetic response. This indicates that students using highly frequent swearing become physiologically desensitized to the severe swearing condition. Also, on the basis of the neuroanatomical structures associated with cortico-subcortical inhibition, this desensitization may suggest a negative influence on cognition, emotion regulation, or even psychological health.
CRETACEOUS-CENOZOIC PALEOBIOGEOGRAPHY OF THE SOUTHERN ROMANIAN BLACK SEA ONSHORE AND OFFSHORE AREAS

Investigations carried out on 22 drillings on the Southern onshore area of the Romanian Black Sea and on one drilling from the Southern offshore area of the Romanian Black Sea are presented here. The lithological/sedimentological investigations and the micropalaeontological (calcareous nannoplankton) quantitative and qualitative analyses revealed several depositional sequences. The oldest identified sedimentary cycle is latest Jurassic (Tithonian) - Early Cretaceous (Berriasian - Valanginian) in age and composed of marine shallow water carbonates. The next cycle, in stratigraphic order, is Barremian - Early Aptian in age, composed of marine shallow water carbonates. A fluvial-lacustrine formation, Middle - Late Aptian in age, was observed only in the drillings from onshore area. The youngest Cretaceous cycle (Santonian – Maastrichtian) is mainly composed of chalks, with intercalations of glauconitic sands towards the base. In the chalk offshore deposits of the Black Sea, a continuous sedimentation took place within the Cretaceous/Tertiary boundary interval. The Paleogene deposits (Middle – Late Eocene) are characterized by the presence of marlstones and claystones. These are overlain by Oligocene black shales, rich in organic matter and fish remains. Miocene, Pliocene and Pleistocene deposits were sedimented in a brackish environment, but several marine influxes probably occured (based on the nannofloras encountered) within the Middle Miocene, latest Miocene-earliest Pliocene and Late Pleistocene. The Cretaceous-Eocene nannofloras are dominated by warm water taxa (Tethyan nannofloras). The occurrence of the Cretaceous calcareous nannoplankton confined to high latitudes (Boreal taxa) within the Late Valanginian, the Barremian - Aptian boundary interval and the latest Maastrichtian, indicate cooler water surfaces. A more significant cooling could be assumed in the Early Oligocene, occuring at the same time with the separation of the Paratethys Realm, and with the appearance of endemic nannofloras in the Black Sea offshore area.
QUALITY OF LIFE AND ASSOCIATED FACTORS AMONG HYPERTENSIVE PATIENTS IN A TERTIARY CARE HOSPITAL IN RIYADH, SAUDI

: Background: Prevalence of hypertension is increasing every year in Saudi Arabia, where it is one of the major risk factors for cardiovascular mortality. Chronic diseases like hypertension can severely affect the quality of life of patients, an important measure of well-being. This study aimed to assess the health-related quality of life and its associated factors among adult hypertensive patients in a tertiary care hospital. Methods: A comparative cross-sectional study was carried in the outpatient clinics of King Khalid University Hospital. It included patients of either sex, aged >=18 years and diagnosed with hypertension for the first group and without hypertension for the comparison group. Data was collected from the patients gave consent, using the WHO Quality of Life-BREF (WHOQOL-BREF) tool. Bivariate and multivariable analyses were carried out using SPSS. Results: A total of 236 hypertensive and 254 non-hypertensive patients were included. Mean quality of life scores were 70.8 (physical), 72.9 (psychological), 76.7 (social) and 67.9 (environmental). The WHOQOL-BREF tool demonstrated high reliability (Chronbach’s alpha 0.91). Adjusted analysis showed that the hypertensive patients had a significantly higher score in the physical health, psychological health and social relationships domains as compared to non-hypertensives, after adjusting for age, gender and other demographic variables. Conclusion: Hypertensive patients scored higher than the non-hypertensive patients, especially in the physical health, psychological health and social relationship domains of QOL. A comprehensive and holistic plan, targeting the various dimensions of health is necessary for improving the quality of life of hypertensive patients.
The Impact of Player Experience on Enjoyment in Tablet Gaming

—In the field of human computer interaction design, player experience and game enjoyment components have not been clearly differentiated and they have often been used to indicate the same entity. To disentangle the two components, this study sheds light on the relationship between player experience and enjoyment in the domain of tablet gaming. This study emphasizes mainly on the analysis and findings portion by empirically illustrating that positive player experience was associated with a higher level of game enjoyment, whereas participants with negative player experience revealed their enthusiasm was dampened during gameplay, yet enjoyment was perceived to be somewhat enjoyable. In sum, game mechanics must produce a balance between positive and negative player experiences for the player to feel rewarded.
Rapid clonal propagation and valepotriates accumulation in cultures of Valeriana jatamansi Jones, a high-value medicinal plant

Summary Valeriana jatamansi , is well known for its medicinal and ethno- botanical values. An ef fi cient and rapid in vitro propagation system for V. jatamansi is presented. The shoot bud explants from V. jatamansi plants were cultured on Murashige and Skoog (MS) media supplemented with different concentrations of plant growth regulators (PGR’s). MS medium supplemented with 2 mg/L of benzyl amino purine (BAP) produced shoot bud regeneration. However, the proliferation rate was slow with fewer shoots. The nodal segments were excised from the in vitro plants raised on BAP (2 mg/L) and multiplied by supplementing MS medium with different PGR’s at different concentrations. Among the tested growth regulators, supplementation of 10% coconut water resulted in maximum shoot length (6 cm), shoot number (13.0), root length (7.5 cm) and root numbers (19.6). The genetic fi delity of the in vitro raised plants was con fi rmed by analysis with RAPD and ISSR markers. GC-MS pro fi ling of the root extract from in vitro raised plant revealed the presence of 21 compounds including valeric acid which is commercially and pharmaceutically important. The protocol developed here will be useful in the future towards large scale commercial production of valepotriates from V. jatamansi.
Inhibitory Effect of lncRNA GHRLOS on Colon Cancer Metastasis and its Molecular Mechanism

Background: LncRNA GHRLOS is a long non-coding RNAs (lncRNAs). Microarray detection for expression profile revealed that lncRNA GHRLOS was significantly under-expressed in colon cancer tissues, while its role in a tumor remained unclear. Objective: To explore the function and biological significance of lncRNA GHRLOS in colorectal cancer and elucidate the molecular mechanism of its influence on the malignant biological behavior in colorectal cancer. Methods: The expression of GHRLOS was detected by collecting the paired tumor tissues and para-cancerous tissues from patients with colorectal cancer. Follow-up data such as recurrence, metastasis, and survival status of patients were collected, and the relationships between the expression level of GHRLOS and indicators such as survival time were analyzed. The expression of lncRNA GHRLOS was changed in colon cancer cells and its influence on migration and invasion of cells was detected. The tumor-bearing model of colorectal cancer in situ in nude mice was constructed to observe the influence of lncRNA GHRLOS expression on metastasis. After the expression of lncRNA GHRLOS was changed, the expression changes of mRNA of the GHRL gene and E-cadherin were detected. Results: The expression of GHRLOS in colorectal tumor tissues was significantly lower than that in para-cancerous tissues. The down-regulation of GHRLOS expression was associated with lymph node metastasis and distant metastasis of colorectal cancer and resulted as an independent risk factor for the prognosis of colorectal cancer patients. In human colorectal cancer cells, the low expression of GHRLOS causes the cells to become more spindle-like, which negatively regulates the expression of the GHRL gene at the post-transcription level, thus significantly inhibiting the expression of E-cadherin and promoting cell migration and invasion. The overexpression of GHRLOS can inhibit tumor metastasis. Conclusion: lncRNA GHRLOS can enhance the expression of E-cadherin by directly affecting the mature mRNA of the GHRL gene in colon cancer tissues, which in turn promotes the metastasis, migration, and invasion of tumor cells.