Miracle-dz/UniFAR-FTUs huggingface dataset:
Hearing Loss and Risk Factors in Very Low Birth Weight Infants

The incidence of sensorineural hearing loss (SNHL) is still high in very low birth weight (VLBW) infants. The purpose of our study was to provide the prevalence rates of SNHL and to analyze the risk factors of hearing impairment and changes in hearing thresholds in a cohort of VLBW infants. A retrospective observational study was conducted in our neonatal intensive care unit (NICU) from 2012 to 2016. All VLBW infants included were screened by transient evoked otoacoustic emissions (TEOAEs) and diagnostic auditory brainstem response (ABR). In total, we enrolled 316 infants and SNHL was diagnosed in 68, leading to an early incidence of 21.5% as 36 infants out of 68 improved. Finally, SNHL was confirmed in 20 patients (6.3%) who needed hearing aids. They were significantly smaller, sicker, had longer hospitalizations, and received more ototoxic therapies. Logistic regression analysis showed that gestational age (GA) influenced the association between drugs and SNHL. The results underlined how the total exposure to antibiotics is significantly associated with SNHL, even after GA correction. In conclusion, GA, birth weight and, above all, the length and complexity of NICU stay quantify the risk of SNHL and should be considered at the individual level for parent counseling.
A distributional review of Bufo boulengeri Lataste, 1879 in northern Morocco with emphasis on occurrence in the Rif Mountains.

1879 (sensu Stock et al., 2006) occurs from the Western Sahara and the Moroccan Atlantic coast eastwards to the Nile valley in Egypt, including several Mediterranean islands (Stock et al., 2008). In Morocco B. boulengeri is distributed throughout the country, from sea level up to 2670 meters altitude in the High Atlas, occupying a variety of habitats from cedar to argan forests and from brackish desert wadis to wet prairies, but is most common in open, relative arid areas (Bons and Geniez, 1996; Schleich et al., 1996). Despite its wide ecological niche and distribution, B. boulengeri seems to be absent in the Rif Mountains and a large part of the northern Atlantic lowland eastwards towards Fes (Schleich et al., 1996; Salvador, 1996; Mateo et al., 2003), excluding several doubtful records (see below). This absence is especially striking due to the occurrence of the species in sub-humid regions of the Middle Atlas (e.g. Tazzeka massif, Bons and Geniez, 1996; western Middle Atlas, Fahd et al., 2007) which are environmentally and climatically very similar to the mountain ranges of the Rif. Three localities in the north-western Rif however have been published during the last decades (see fig. 1); Ceuta (Sebta) and Tetouan both from Bons and Geniez (1996) and the basin of the Oued Laou near Bab Taza (Fahd and Mediani, 2007). Because of the doubtful validity of the first two records (Fahd et al., 2002; Mateo et al., 2003) and the discovery of several new localities of B. boulengeri by the authors we regard it noteworthy to present a distributional overview of this species from northern Morocco with emphasis on occurrence in the Rif Mountains. The new records correspond with the numbers displayed on figure 1.
Precise Memory is Predicted by Learning-Induced Sensory System Neurophysiological Plasticity

Despite identical learning experiences, individuals differ in the memory formed of those experiences. Memory formed with sensory specificity determines its utility for selectively cueing subsequent behavior, even in novel situations. If an individual forms generalized memory, then there is potential for novel sensory cues to interfere with accurate behavioral performance. Here, a rodent model of auditory learning capitalized on individual differences in learning-induced auditory neuroplasticity to identify and characterize neural substrates for sound-specific (vs. general) memory of the training signal’s acoustic frequency. Animals with naturally or pharmacologically induced signal-“specific” memory revealed behaviorally, exhibited long-lasting signal-specific neurophysiological plasticity in auditory cortical and subcortical evoked responses, while learning-induced changes were not detected in animals with “general” memories. Individual differences validated this brain-behavior relationship, such that the degree of change in neurophysiological responses could be used to determine the precision of memory formation.
Protective role of perivascular adipose tissue in the cardiovascular system

This review provides an overview of the key role played by perivascular adipose tissue (PVAT) in the protection of cardiovascular health. PVAT is a specific type of adipose tissue that wraps around blood vessels and has recently emerged as a critical factor for maintenance of vascular health. Through a profound exploration of existing research, this review sheds light on the intricate structural composition and cellular origins of PVAT, with a particular emphasis on combining its regulatory functions for vascular tone, inflammation, oxidative stress, and endothelial function. The review then delves into the intricate mechanisms by which PVAT exerts its protective effects, including the secretion of diverse adipokines and manipulation of the renin-angiotensin complex. The review further examines the alterations in PVAT function and phenotype observed in several cardiovascular diseases, including atherosclerosis, hypertension, and heart failure. Recognizing the complex interactions of PVAT with the cardiovascular system is critical for pursuing breakthrough therapeutic strategies that can target cardiovascular disease. Therefore, this review aims to augment present understanding of the protective role of PVAT in cardiovascular health, with a special emphasis on elucidating potential mechanisms and paving the way for future research directions in this evolving field.
Reply to Uxa (2016) Discussion on Active Layer Thickness Prediction on the Western Antarctic Peninsula by Wilhelm et al. (2015)

Uxa ( ) used alternative assumptions to calculate active‐layer thicknesses (ALTs) on Amsler Island, Western Antarctic Peninsula, and concluded that assumptions in Wilhelm et al. ( ) overestimate ALTs in the region. Here, we accept that the core of his argument is correct, but we contend that observations using multiple devices, along with the HYDRUS model, indicate that in some cases assumptions used by Uxa ( ) overcompensate and predict an unrealistically thin active layer for the study area. Observed and predicted ALTs are much greater than would be expected, relative to measurements farther to the north. Such a thick active layer could be due to glacial proximity and topographically controlled hydraulic features that promote wetter‐than‐expected soils. Copyright © 2016 John Wiley & Sons, Ltd.
USE OF COCONUT HUSKS TO FACILITATE THE REMOVAL OF H2S FROM BIOGAS

The study investigates the potential of coconut husks in purifying biogas, a common issue in the use of biogas due to the high costs and environmental impact of expensive purification technologies. The study used an experimental setup generating biogas from kitchen waste and analysed its composition using an industry-standard biogas analyser. Coconut husks could remove hydrogen sulphide (H2S), with a high percentage removal efficiency of 54% at a column length of 0.5 m from the inlet. Based on the results, 2 kg of coconut husk could purify 837 L of biogas, with a removal efficiency of approximately 62%, before exhaustion. This suggests that coconut husks can be used in biogas purification to remove H2S, which is the most challenging component as it can corrode metal parts when used at high concentrations above 750 ppm. Further research is needed on large-scale purification using coconut husks at high pressure to allow more gas adsorption by the purification media.
The Effects of Larval Cryopreservation on the Epigenetics of the Pacific Oyster Crassostrea gigas

High mortalities and highly variable results during the subsequent development of post-thaw larvae have been widely considered as key issues restricting the application of cryopreservation techniques to support genetic improvement programs and hatchery production in farmed marine bivalve species. To date, few studies have been undertaken to investigate the effects of cryodamage at the molecular level in bivalves. This study is the first to evaluate the effect of larval cryopreservation on the epigenetics of the resultant progenies of the Pacific oyster Crassostrea gigas. The results show that the level of DNA methylation was significantly (p < 0.05) higher and lower than that of the control when the trochophore larvae were revived and when they developed to D-stage larvae (day 1 post-fertilization), respectively, but the level returned to the control level from day 8 post-fertilization onwards. The expression of the epigenetic regulator genes DNMT3b, MeCP2, JmjCA, KDM2 and OSA changed significantly (p < 0.05) when the trochophore larvae were thawed, and then they reverted to the control levels at the D- and later larval developmental stages. However, the expression of other epigenetic regulator genes, namely, MBD2, DNMT1, CXXC1 and JmjD6, did not change at any post-thaw larval developmental stage. For the newly thawed trochophore larvae, the amount of methylated H3K4Me1 and H3K27Me1 significantly changed, and the expression of all Jumonji orthologs, except that of Jumonji5, significantly (p < 0.05) decreased. These epigenetic results agree with the data collected on larval performances (e.g., survival rate), suggesting that the effect period of the published cryopreservation technique on post-thaw larvae is short in C. gigas.
Exploration of Bibliometric Research in Accounting Information: Trends and Challenges

This paper explores the changing environment of research trends and problems in accounting information through a thorough bibliometric analysis. With the aid of sophisticated visualization tools such as Vosviewer and the databases Scopus and Web of Science, we examine a selected dataset of academic papers from 1963 to 2023. Within the domain, our analysis reveals topic clusters, keyword occurrences, collaborative networks, and influential works. Interdisciplinarity is highlighted by collaborative networks, which highlight the increasing convergence of accounting, finance, economics, and technology. Citation analysis identifies important works that have influenced the subject and provides insights into long-lasting contributions. Thematic clusters offer academics a way to navigate a variety of study frontiers, from the complex relationships between accounting standards and the capital market to the revolutionary impact of technology. The continuous emphasis on accounting information systems is highlighted by keyword occurrence analysis, which also reveals new themes like big data and the internet. The amalgamation of these discoveries functions as a guide for academics, professionals, and decision-makers, directing forthcoming research projects towards domains of importance, novelty, and cross-disciplinary investigation.
Health first, convenience second: Caregiver perspectives of commercially produced complementary foods in five Southeast Asian capital cities

Abstract Caregivers in low‐ and middle‐income countries increasingly feed commercially produced complementary foods (CPCF) to older infants and young children—shaped by factors including industry promotion. The dynamics of CPCF consumption and caregiver knowledge, attitudes and behaviours regarding complementary feeding practices are poorly understood in these settings. We examined how caregiver knowledge/attitudes/behaviours about CPCF shape the feeding of older infants and young children in the capital cities of five countries in Southeast Asia (Bangkok, Hanoi, Jakarta, Kuala Lumpur, Manila). An online, web‐based, cross‐sectional panel survey was conducted among mothers of a child aged 6−23 months. One hundred participants were included in each of the five capital cities. Questionnaires were undertaken in the official language of each city. Data were analysed in Stata (version 17.0), using χ 2 tests to examine difference between variables of interest. All mothers purchased CPCF for their youngest child aged 6−23 months at the time of survey. CPCF were commonly fed to children at least once per day, and in many of the five cities at most or every feeding. While factors such as convenience and affordability influenced CPCF purchase, mothers primarily purchased CPCF for nutritional reasons. The most common source of feeding information was health care professionals, followed by social media. CPCF are ubiquitous in the diets of older infants and young children of educated middle–upper socioeconomic status mothers in capital cities of Southeast Asia, with perceived healthiness a key driver in selecting CPCF. A strong governmental regulatory response to industry marketing/promotion will be critical to addressing CPCF appropriateness, including health and nutritional claim use.
Paleozoic Evolution and Metallogeny of Pericratonic Terranes at the Ancient Pacific Margin of North America.

This is an exceptional product that provides a new paradigm of understanding to Cordilleran geology. This hardcover volume includes18 papers and an index, as well as two large-format folded plates of critical figures and a CD-ROM. The CD provides high- and low-resolution PDFs of each of the papers, as well as data repositories that accompany most of the papers and attest to the considerable amount of new data contained within. Additionally, the CD contains large PDFs of more than 30 geologic maps published by the different government agencies that employ the authors. Geographically, the papers are divisible into six contributions on Yukon and northernmost British Columbia, six on southeastern British Columbia, and other papers with regional compilations. A single paper is dedicated to Alaska. This publication is the result of a five-year cooperative geo-science program, the Ancient Pacific Margin National Mapping Program, that has brought together geologists from the Yukon Geological Survey, the British Columbia Geological Survey, the Geological Survey of Canada, and the U.S. Geological Survey with university researchers, students, and industry personnel. The focus of …
INTEGRATING ARTIFICIAL INTELLIGENCE IN DISEASE DIAGNOSIS, TREATMENT, AND FORMULATION DEVELOPMENT: A REVIEW

Artificial intelligence (AI) is rapidly advancing and significantly impacting clinical care and treatment. Machine learning and deep learning, as core digital AI technologies, are being extensively applied to support diagnosis and treatment. With the progress of digital health-care technologies such as AI, bioprinting, robotics, and nanotechnology, the health-care landscape is transforming. Digitization in health-care offers various opportunities, including reducing human error rates, improving clinical outcomes, and monitoring longitudinal data. AI techniques, ranging from learning algorithms to deep learning, play a critical role in several health-care domains, such as the development of new health-care systems, improvement of patient information and records, and treatment of various ailments. AI has emerged as a powerful scientific tool, capable of processing and analyzing vast amounts of data to support decision-making. Numerous studies have demonstrated that AI can perform on par with or outperform humans in crucial medical tasks, including disease detection. However, despite its potential to revolutionize health care, ethical considerations must be carefully addressed before implementing AI systems and making informed decisions about their usage. Researchers have utilized various AI-based approaches, including deep and machine learning models, to identify diseases that require early diagnosis, such as skin, liver, heart, and Alzheimer’s diseases. Consequently, related work presents different methods for disease diagnosis along with their respective levels of accuracy, including the Boltzmann machine, K nearest neighbor, support vector machine, decision tree, logistic regression, fuzzy logic, and artificial neural network. While AI holds immense promise, it is likely to take decades before it completely replaces humans in various medical operations.
The Four Color Problem Assaults And Conquest

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Problematic Internet use and cyberbullying in university students

Objectives: Problematic Internet use can have a negative impact on the daily lives and communications of teenagers, who constitute the most active user base of the Internet, and can be accompanied by issues such as cyberbullying. Methods: The quantitative descriptive method was used in this study to examine the relationship between problematic Internet use and cyberbullying among university students. The study group of this research consisted of 883 students studying in the faculty of health sciences of a university in Ankara city center during 2018–2019 academic year. The data were collected using a sociodemographic features data form, Problematic Internet Use Scale (PIUS), and revised cyber bullying ınventory-II (RCBI-II). Mann–Whitney U, Kruskal–Wallis H test statistics, and Spearman correlation analysis were used to evaluate the data. Results: The research found that the problematic Internet use of the participants is on the medium level. Furthermore, it was discovered that 56.4% of the participants participated in cyberbullying, and 66.5% were victims of cyberbullying. There was a positive, middle level, significant relationship between cyberbullying and cyber victimization, as well as a positive, weak, significant relationship between PIUS total score and cyberbullying and cyber victimization. The RCBI-II index score increased in parallel with the participants’ PIUS index score. Conclusion: It is seen that the increase in the duration of Internet use increases the problematic Internet use, and the problematic Internet use increases the frequency of cyberbullying and victimization.
Establishment and Thorough Characterization of Xenograft (PDX) Models Derived from Patients with Pancreatic Cancer for Molecular Analyses and Chemosensitivity Testing

Simple Summary Patients with pancreatic cancer (PC) still have a poor prognosis as therapeutic options are quite limited for both resectable and inoperable as well as metastasized late-stage tumors. The aim of our study was to generate a PC-PDX in vivo platform of well-characterized models. For this, patient tissues were implanted into immunocompromised mice and established PDXs were examined for morphology, and analyzed regarding their response to standard of care (SoC) drugs, HLA status and molecular characteristics. Our established 45 PC-PDX models closely resemble patient tumor morphology, mutational status, gene expression profile and sensitivity toward gemcitabine, abraxane and 5-FU. Moreover, we show replacement of human tissue by murine stroma, and that stroma components collagen I, α-SMA, FAP and SPARC remain unaffected by the implantation route (s.c. vs. orthotopic) as well as by SoC drug treatment. The comprehensive data set of our PDX models allows testing for new therapeutic targets and novel therapies for PC. Abstract Patient-derived xenograft (PDX) tumor models are essential for identifying new biomarkers, signaling pathways and novel targets, to better define key factors of therapy response and resistance mechanisms. Therefore, this study aimed at establishing pancreas carcinoma (PC) PDX models with thorough molecular characterization, and the identification of signatures defining responsiveness toward drug treatment. In total, 45 PC-PDXs were generated from 120 patient tumor specimens and the identity of PDX and corresponding patient tumors was validated. The majority of engrafted PDX models represent ductal adenocarcinomas (PDAC). The PDX growth characteristics were assessed, with great variations in doubling times (4 to 32 days). The mutational analyses revealed an individual mutational profile of the PDXs, predominantly showing alterations in the genes encoding KRAS, TP53, FAT1, KMT2D, MUC4, RNF213, ATR, MUC16, GNAS, RANBP2 and CDKN2A. Sensitivity of PDX toward standard of care (SoC) drugs gemcitabine, 5-fluorouracil, oxaliplatin and abraxane, and combinations thereof, revealed PDX models with sensitivity and resistance toward these treatments. We performed correlation analyses of drug sensitivity of these PDX models and their molecular profile to identify signatures for response and resistance. This study strongly supports the importance and value of PDX models for improvement in therapies of PC.
Microanatomical, histochemical and morphometric features of the major and selected minor salivary glands in laboratory Wistar rat

The major and minor salivary glands are responsible for saliva production, a fluid drained in the oral cavity that will be involved in several functions at this level. The present study aimed to compare the microanatomy of the major (parotid, mandibular, sublingual) and minor salivary glands (von Ebner's and Weber's) of the Wistar rat, from a histological, histochemical and morphometrically point of view. Predominantly serous glands (parotid, mandibular and von Ebner's) showed differences in the secretion composition on both PAS and alcian blue reactions. The same observations were identified also for the mostly mucous salivary glands (sublingual and Weber). In terms of surface dimensions, the measurements suggested that the mucous acini have a greater surface compared with the serous ones, and, at the same time, a better‐represented polymorphism. In conclusion, the major and minor salivary glands in Wistar rats, a commonly used species in experimental procedures, showed similarities with other species including humans, but some structural traits are breed‐specific, this finding is very important for an extensive understanding of the morphophysiology of the salivary glands.
Évolution paléogéographique de la plaine du Roussillon au cours de la seconde moitié de l'Holocène : implication sur la répartition des sites néolithiques

A partir d'une base de donnees 3D des depots holocenes integree sous SIG, l'evolution geodynamique de la plaine du Roussillon a ete constituee. Les modalites de la transgression post-glaciaire et son influence sur la repartition des sites du Neolithique sont discutees.
Fuzzy-Based Adaptive VOC Methods for Parallel Inverters

This letter is focused on different kinds of virtual oscillator control (VOC) schemes that can be used to regulate the power inverters. Deadzone oscillator (DZO), Van der Pol oscillator (VdPO), and New-VdPO-based VOC techniques are presented in this work. The output voltage falls as the load increases with the aforementioned control methods, which might be problematic for sensitive equipment that demands a constant voltage. To overcome this limitation, the authors proposed adaptive VOC methods (DZO-Adaptive, VdPO-Adaptive, and New-VdPO-Adaptive) based on fuzzy logic algorithms (FLAs). The proposed New-VdPO-Adaptive-based VOC controller has good voltage regulation and lower total harmonic distortion (THD). The simulation and hardware results of the FLA-based adaptive VOC methods are presented to determine the effectiveness of the proposed control schemes.