Miracle-dz/UniFAR-FTUs huggingface dataset:
Legacies of inequality, legacy lead exposures, and improving population well-being

The findings in McFarland et al. (1) are at once disturbing and reassuring. The bad news is captured in their title: “Half of US population exposed to adverse lead levels in early childhood. ” That striking figure, based on a welldesigned and rigorous analysis, will make readers take note, as well it should. We have known for some time now the deleterious impact of lead exposure on a wide range of features in young children’s development, including the disruption of multiple organ systems, cognitive deficits, emotional dysregulation, and impaired self-control. The authors also note the convergent evidence on what they call “legacy lead exposures” which are revealed in multiple outcomes later in life such as educational attainment, income mobility, delinquent behavior, and physical health. The bundle of adversities associated with childhood lead exposure, even if individually subtle, cumulate over time and can generate long-term effects (2–4). How can there be grounds for optimism in a study showing that half the current population of adults has been exposed to the detrimental effects of lead in childhood? The authors’ (1) birth cohort design and population projections throughout the 21st century provide an answer. We know that leaded gasoline declined substantially in the United States starting in the mid-1970s and that there have been subsequent declines in children’s levels of lead. But the innovation of the McFarland et al. study is to estimate cohortspecific blood-lead levels (BLLs) by age in 2015 based on the National Health and Nutrition Examination Survey (NHANES), a representative sample of US children. Constructing serial cross-sectional measures of BLLs across four decades of the NHANES merged with census and mortality data, the authors provide past, present, and estimated future trends in lead exposure, along with consequences for cognitive ability. Although levels of childhood lead exposure among current adults are alarmingly high, and the authors estimate considerable population losses over time in cognitive ability, the trends in lead exposure are nonetheless in the right direction. The decline across successive cohorts is so steep that nearly all of today’s children have BLLs less than 5 μg/ dL, traditionally considered to be low even though no lead level is now considered safe. McFarland et al. project that, as we reach 2100, nearly all adults will have experienced leadfree childhoods if 2015 exposure levels hold. This means that the trajectory of the United States is on the right path, at least with respect to the fading of prior lead exposures among adult populations. That is good news indeed.
A tri‐band monopole filtering antenna using multimode resonators

A simple tri‐band monopole filtering antenna using multimode resonators is proposed. Two novel microstrip open‐loop multimode resonators and a monopole ring antenna with an open stub are integrated together on the same layer of the substrate. Compared with the traditional monopole antenna, the integration makes the proposed antenna operate at 2.4/5.2/6.5 GHz and realize two radiation zeroes at 2 and 3.3 GHz. It leads to the high selectivity for 2.4 GHz. The measured results, including the reflection coefficient, peak realized gain and radiation pattern agree well with the simulated results.
The Relationship between Hypertension and Cancer.

BACKGROUND Hypertension and cancer are both common due to the aging of the population and the advances in medical treatment which result in increased survival of cancer patients today. More patients with cancer; therefore, present with hypertension, which is attributed to different factors, including genetics and age as well as the type of tumor and cancer-related treatments. Given the increased cardiovascular and mortality risk related to hypertension, it is important to appropriately identify and treat hypertension, particularly in the population of vulnerable cancer patients. In this article we discuss the epidemiology, different etiologies, and approaches to the management of hypertension in cancer patients.
Lithium upregulates growth-associated protein-43 (GAP-43) and postsynaptic density-95 (PSD-95) in cultured neurons exposed to oxygen-glucose deprivation and improves electrophysiological outcomes in rats subjected to transient focal cerebral ischemia following a long-term recovery period

ABSTRACT Objectives Lithium has numerous neuroplastic and neuroprotective effects in patients with stroke. Here, we evaluated whether delayed and short-term lithium treatment reduces brain infarction volume and improves electrophysiological and neurobehavioral outcomes following long-term recovery after cerebral ischemia and the possible contributions of lithium-mediated mechanisms of neuroplasticity. Methods Male Sprague Dawley rats were subjected to right middle cerebral artery occlusion for 90 min, followed by 28 days of recovery. Lithium chloride (1 mEq/kg) or vehicle was administered via intraperitoneal infusion once per day at 24 h after reperfusion onset. Neurobehavioral outcomes and somatosensory evoked potentials (SSEPs) were examined before and 28 days after ischemia-reperfusion. Brain infarction was assessed using Nissl staining. Primary cortical neuron cultures were exposed to oxygen-glucose deprivation (OGD) and treated with 2 or 20 μM lithium for 24 or 48 h; subsequent brain-derived neurotrophic factor (BDNF), growth-associated protein-43 (GAP-43), postsynaptic density-95 (PSD-95), and synaptosomal-associated protein-25 (SNAP-25) levels were analyzed using western blotting. Results Compared to controls, lithium significantly reduced infarction volume in the ischemic brain and improved electrophysiological and neurobehavioral outcomes at 28 days post-insult. In cultured cortical neurons, BDNF, GAP-43, and PSD-95 expression were enhanced by 24- and 48-h treatment with lithium after OGD. Conclusion Lithium upregulates BDNF, GAP-43, and PSD-95, which partly accounts for its improvement of neuroplasticity and provision of long-term neuroprotection in the ischemic brain. Abbreviations: BDNF: brain-derived neurotrophic factor; ECM: extracellular matrix; EDTA: ethylenediaminetetraacetic acid; GAP-43: growth-associated protein-43; GSK-3β: glycogen synthase kinase-3β; HBSS: Hank’s balanced salt solution; LCBF: local cortical blood perfusion; LDF: laser-Doppler flowmetry; MCAO: middle cerebral artery occlusion; MMP: matrix metalloproteinase; NMDA: N-methyl-D-aspartate; NMDAR: N-methyl-D-aspartate receptor; OCT: optimal cutting temperature compound; OGD: oxygen-glucose deprivation; PSD-95: postsynaptic density-95; SDS: sodium dodecyl sulfate; SNAP-25: synaptosomal-associated protein-25; SSEP: somatosensory evoked potential
The effects of partial wrist denervation in wrist osteoarthritis: patient-reported outcomes and objective function

This prospective longitudinal study aimed to analyse the effect of partial wrist denervation on patient-reported outcomes, quality of life and objective function in symptomatic wrist osteoarthritis during the first year after surgery. Sixty consecutive patients underwent an anterior and posterior interosseous neurectomy during 2018–2020. Disabilities of the Arm, Shoulder and Hand, Patient-Rated Wrist Evaluation, EuroQol-5D-3L, pain at rest and on load, and objective function were assessed preoperatively and 3, 6 and 12 months postoperatively. Generalized estimating equations were used to analyse the effect on the outcome variables. Disabilities of the Arm, Shoulder and Hand, Patient-Rated Wrist Evaluation and pain scores improved significantly postoperatively with no decline over time, but no patient reported outcome measure reached the minimal clinically important difference. Quality of life, strength and range of motion did not improve. We found no complications. Seventeen patients needed further surgery during the study period. More studies are needed to evaluate whether denervation is truly effective or not. Level of evidence: II
Let-7 underlies metformin-induced inhibition of hepatic glucose production

Significance A clear mechanistic understanding of metformin’s antidiabetic effects is lacking. This is because suprapharmacological concentrations of metformin have been used in most studies. Using mouse models and human primary hepatocytes, we show that metformin, at clinically relevant doses, suppresses hepatic glucose production by activating a conserved regulatory pathway encompassing let-7, TET3, and a fetal isoform of hepatocyte nuclear factor 4 alpha (HNF4α). We demonstrate that metformin no longer has potent antidiabetic actions in a liver-specific let-7 loss-of-function mouse model and that hepatic delivery of let-7 ameliorates hyperglycemia and improves glucose homeostasis. Our results thus reveal an important role of the hepatic let-7/TET3/HNF4α axis in mediating the therapeutic effects of metformin and suggest that targeting this axis may be a potential therapeutic for diabetes.
Impact of state of emergency for coronavirus disease 2019 on hospital visits and disease exacerbation: the Japan COVID-19 and Society Internet Survey

Abstract Background Studies on the impact of coronavirus disease 2019 (COVID-19) on people’s routine medical care are limited, and understanding the factors associated with medical care avoidance can inform us about the ongoing pandemic. Objectives We aimed to assess the impact of Japan’s state of emergency and stay-at-home policy for COVID-19 on hospital visits and disease exacerbation; we also identified related factors. Methods This cross-sectional study used data from the Japan COVID-19 and Society Internet Survey (JACSIS), which included randomly sampled research agency panellists in Japan. Among the 28,000 participants, we included 7,747 respondents who reported having any disease. We described baseline characteristics and avoidance-related hospital visit outcomes. We used multivariable logistic regression analyses to assess the association between chronic diseases and outcomes of hospital visit avoidance. Results Among 7,747 participants, 17.7% of patients with chronic diseases avoided hospital visits, 2.1% of patients postponed hospitalization or surgery, 4.9% of patients ran out of drug, and 5.3% of patients experienced disease exacerbation during the COVID-19 pandemic in April and May 2020. Exacerbations occurred mostly in participants with mental diseases, chronic pain and headache, and diabetes (OR 3.33 [95% confidence interval (CI): 2.51–4.41], 2.83 [95% CI: 2.19–3.66], and 1.53 [95% CI: 1.10–2.13], respectively). Patients with cardiovascular disease or cancer did not experience exacerbation [OR 0.55 (95% CI: 0.31–0.97), 0.79 (95% CI: 0.43–1.45)]. Conclusions The rates of hospital visit avoidance and exacerbation varied among patients with different diseases under the COVID-19 stay-at-home policy in April and May 2020, and disease-specific preparedness may be necessary for the pandemic.
Neural decoding of semantic concepts: a systematic literature review

Objective. Semantic concepts are coherent entities within our minds. They underpin our thought processes and are a part of the basis for our understanding of the world. Modern neuroscience research is increasingly exploring how individual semantic concepts are encoded within our brains and a number of studies are beginning to reveal key patterns of neural activity that underpin specific concepts. Building upon this basic understanding of the process of semantic neural encoding, neural engineers are beginning to explore tools and methods for semantic decoding: identifying which semantic concepts an individual is focused on at a given moment in time from recordings of their neural activity. In this paper we review the current literature on semantic neural decoding. Approach. We conducted this review according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines. Specifically, we assess the eligibility of published peer-reviewed reports via a search of PubMed and Google Scholar. We identify a total of 74 studies in which semantic neural decoding is used to attempt to identify individual semantic concepts from neural activity. Main results. Our review reveals how modern neuroscientific tools have been developed to allow decoding of individual concepts from a range of neuroimaging modalities. We discuss specific neuroimaging methods, experimental designs, and machine learning pipelines that are employed to aid the decoding of semantic concepts. We quantify the efficacy of semantic decoders by measuring information transfer rates. We also discuss current challenges presented by this research area and present some possible solutions. Finally, we discuss some possible emerging and speculative future directions for this research area. Significance. Semantic decoding is a rapidly growing area of research. However, despite its increasingly widespread popularity and use in neuroscientific research this is the first literature review focusing on this topic across neuroimaging modalities and with a focus on quantifying the efficacy of semantic decoders.
Multiple eruptive squamoproliferative lesions during anti‐PD1 immunotherapy for metastatic melanoma: Pathogenesis, immunohistochemical analysis and treatment

Treatment with anti‐PD1 inhibitors may enhance the risk for developing low grade squamoproliferative skin tumors. Immunohistochemical (IHC) analysis of the immune tumor microenvironment (TME) allows exploration of the pathogenesis and relationship with the PD1/PDL1 axis. Patients with eruptive keratoacanthoma (KA)‐like lesions were recruited from the Melanoma Institute Australia, a tertiary referral specialist melanoma treatment center from January 2015 to August 2017. Clinicopathologic evaluation and IHC features of tumor cells (PDL1 expression) and peritumoral microenvironment (PD1, FOXP3, PDL1, CD4:CD8 expressing cells) in 12 eruptive KA‐like lesions, were compared with solitary KAs in age and sex matched non‐anti‐PD1 treated controls. Four patients with repeated episodes of eruptive KA‐like and lichenoid lesions developing 2–7 months after commencing pembrolizumab for AJCC stage IV melanoma, were recruited. Eruptive KA‐like squamoproliferative lesions occurred in sun exposed sites and in areas of resolving, concomitant or delayed lichenoid reactions. Histologically, the lesions were well‐differentiated squamoproliferative lesions resembling infundibulocystic squamous cell carcinoma or KA. IHC of cases and controls revealed low PDL1 expression of both squamous tumor cells and the TME immune cells. The numbers of immunosuppressive FOXP3 positive Tregs and PD1‐expressing T‐cells were higher in the cases than the controls but the CD4:CD8 ratio (2:1) was similar. The patients best responded to acitretin and were managed surgically if they demonstrated neoplastic features. Accelerated squamoproliferative growth in actinically damaged keratinocytes associated with lichenoid eruptions may be unmasked in patients treated with anti‐PD1 immunotherapy potentially contributed to by a local cutaneous immunosuppressed TME.
Perception of the Food and Drug Administration Electronic Cigarette Flavor Enforcement Policy on Twitter: Observational Study

Background On January 2, 2020, the US Food and Drug Administration (FDA) released the electronic cigarette (e-cigarette) flavor enforcement policy to prohibit the sale of all flavored cartridge–based e-cigarettes, except for menthol and tobacco flavors. Objective This research aimed to examine the public perception of this FDA flavor enforcement policy and its impact on the public perception of e-cigarettes on Twitter. Methods A total of 2,341,660 e-cigarette–related tweets and 190,490 FDA flavor enforcement policy–related tweets in the United States were collected from Twitter before (between June 13 and August 22, 2019) and after (between January 2 and March 30, 2020) the announcement of the FDA flavor enforcement policy. Sentiment analysis was conducted to detect the changes in the public perceptions of the policy and e-cigarettes on Twitter. Topic modeling was used for finding frequently discussed topics about e-cigarettes. Results The proportion of negative sentiment tweets about e-cigarettes significantly increased after the announcement of the FDA flavor enforcement policy compared with before the announcement of the policy. In contrast, the overall sentiment toward the FDA flavor enforcement policy became less negative. The FDA flavor enforcement policy was the most popular topic associated with e-cigarettes after the announcement of the FDA flavor enforcement policy. Twitter users who discussed about e-cigarettes started to talk about other alternative ways of getting e-cigarettes after the FDA flavor enforcement policy. Conclusions Twitter users’ perceptions of e-cigarettes became more negative after the announcement of the FDA flavor enforcement policy.
Artifacts in magnetic resonance imaging caused by dental materials: a systematic review

Objectives: The purpose of this systematic review was to search in literature in which severity unintended effects are caused by dental materials in magnetic resonance imaging (MRI), such as to evaluate whether these artifacts hamper the diagnosis in the head and neck region. Materials and Methods: Clinical studies showing the severity of artifacts which dental materials are capable of causing in MRI of head and neck, such as their influence on diagnostic accuracy, were included in this review. The searches were conducted in four electronic databases (PubMed/Medline, Embase, Scopus and Web of Science), and a manual search was made in the reference lists of papers screened for full-text reading. Risk of bias was assessed using “Quality Assessment Tool for Diagnostic Accuracy Studies-2” (QUADAS-2). The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to assess the quality of evidence. Results: From 151 studies selected for full-reading, 19 were considered eligible for this review. Artifacts caused by orthodontic appliances were well-documented, and stainless steel brackets were the materials most likely to cause artifacts in MR imaging of head and neck. The literature was scarce for dental implants and restorations. Diagnoses within the oral cavity, but also those of the brain and craniofacial structures, were affected. Conclusion: Artifacts caused by orthodontic appliances may affect the diagnosis in oral cavity and craniofacial structures. Data regarding dental implants and prosthodontics restorations were inconclusive. The severity of artifacts in MRI and their influence on diagnosis is dependent on dental material features, location in the oral cavity, and magnetic resonance parameters.
A plant-based diet differentially affects the global hepatic methylome in rainbow trout depending on genetic background

ABSTRACT Replacing fish meal and oil in trout diets with plant-derived ingredients is a contemporary challenge to move towards more sustainable aquaculture practices. However, such dietary replacement causes hepatic metabolic changes that have not yet been elucidated. Here, we aimed to decipher the effect of a 100% plant-based diet on the hepatic global DNA methylation landscape in trout and assess whether changes depend on fish genetic background. We analysed the global methylome and the expression of DNA (de)methylation-related genes of three isogenic lines that exhibit similar growth when fed a marine resource-based diet (M diet), but differ in their responses to a plant-based diet (V diet). Our results revealed that the V diet induced a decrease in 5-cytosine combined with an increase in 5-hydroxymethylcytosine in two of the three analysed lines. For one of these 2 affected lines, when fed the M diet but at the same feed intake of the V diet (MR), no methylome differences were highlighted between M and MR or between MR and V-fed trout whereas for the other affected line, M fed trout displayed a divergent methylome profile from MR and V fed fish. DNA (de)methylation-related genes were also affected by the V or MR diets. Our findings showed that the global hepatic methylome of trout is affected by a V diet, depending on genetic background. This latter effect seems to be due to either a decreased feed intake alone or combined with the effect of the dietary composition per se.
Beyond 'more crop per drop': evolving thinking on agricultural water productivity - IWMI research report 169

This report aims to provide key highlights from two decades of IWMI research and the broader irrigation literature on agricultural water productivity, with an emphasis on the evolution and application of the concept, highlighting its contributions and limitations while identifying opportunities for further refinements in the way it is understood and applied. Chapter two describes the origins of the concept of agricultural water productivity and its methodological developments. Chapter three illustrates the different ways the concept has been operationalized in applied research, offers a description of the pathways—with their associated interventions, for improving water productivity, and discusses the contributions to broader development objectives. Based on these, and considering the broader literature, Chapter four presents a set of key lessons and insights from two decades of research on water productivity. Chapter five concludes by highlighting how a focus on agricultural water productivity has brought greater attention to critical water scarcity and management issues. Important strategic opportunities remain, however, for continued improvements in technologies and management practices, data sources, and interdisciplinary research to develop and apply more comprehensive approaches to address water scarcity concerns and, ultimately, make progress towards broader development objectives.
´You are not yourself anymore´: The place of the ethical demand in a practical home care context.

THE STUDY'S RATIONALE The Scandinavian nursing tradition is based on caring science as the ontological backdrop. This means that meeting the patient with openness and respect is essential in care. The experiences of an elderly woman receiving home nursing provide insight into a world many healthcare workers need to understand; meaning what is important in the encounter with the fragile old patient whose voice is not often heard in the society nor in research. Caring science with its person-oriented care clashes with the New Public Management's ideal for municipal health care in Norway, at the expense of the needs of the elderly patients. AIMS AND OBJECTIVES This article aims to express the phenomenon of lived experience as presented by an elderly woman, more specifically her experience of care in home nursing run according to the principles of new public management. METHODOLOGICAL DESIGN The article is based on an empirical narrative in the form of an individual qualitative research interview. FINDINGS The patient has needs that cannot be defined without the nurse having an ethical understanding of what may be important in the patient´s lifeworld. The core findings are: Feeling disregarded as a human being, Broken agreements, Surrendering in anonymous relationships and Each day is a different day with altered needs. CONCLUSION The system of New Public Management sets a strain on the time at hand for the nurse to develop a relationship that acknowledges and supports the patient´s life courage. The ethical demand and care ethics can explain how the patient´s will to live can be preserved, and provide knowledge of how the caregiver can best attend to the patient's ways of expressing what is important to her. Nevertheless, within the time at disposal, the nurse has an opportunity to either marginalize or strengthen the old person´s dignity.