Miracle-dz/UniFAR-FTUs huggingface dataset:
INSIGHTS INTO VIRULENCE AND ANTIMICROBIAL RESISTANCE PLASMID ASSOCIATED GENES OF ESBL ESCHERICHIA COLI ASSOCIATED WITH ARTHRITIS IN CHICKENS IN EGYPT.

1. Bacteriology, Immunology and Mycology Department, Faculty of Veterinary Medicine, Benha University, Egypt. 2. Animal Health Research Institute, Tanta branch, Egypt. 3. Veterinary Hospital, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt. Manuscript Info Abstract . Manuscript History Received: 04 November 2018 Final Accepted: 06 December 2018 Published: January 2019
The effects of fragmented and sticky smartphone use on distraction and task delay

The smartphone has become an integral part of adolescents’ daily life. Despite the countless affordances of smartphones, concerns have been raised about their enormous potential to cause failures in self-regulation, such as distraction and task delay. The current study investigated whether two smartphone usage patterns, fragmented and sticky smartphone use, are associated with distraction and task delay. For three weeks, we logged the smartphone usage of 160 adolescents (733,359 observations) and assessed their distraction and task delay six times a day with experience sampling (12,723 observations). Using Dynamic Structural Equation Modeling, we found that, overall, adolescents felt more distracted when their smartphone use was more fragmented or sticky. Exploratory analyses indicated that 77% of adolescents experienced increased distraction (i.e., β > .05) when their smartphone use was more fragmented, and 55% when it was sticky. Overall, adolescents did not report more task delay as their smartphone use was more fragmented or sticky. Nonetheless, 22% experienced increased task delay when their smartphone use was more fragmented, and 42% when it was sticky. Together, our findings underline the dynamic nature of smartphone use and its differential impact on self-regulation outcomes.
Dampak Rasio Keuangan terhadap Kebijakan Dividen

Penelitian ini dilakukan untuk menguji pengaruh Debt to Equity Ratio (DER), Net Profit Margin (NPM), Asset Turnover (ATO) terhadap Dividen Payout Ratio (DPR) pada perusahaan perbankan yang terdaftar di Bursa Efek Indonesia selama periode 2007 - 2010. Populasi dari penelitian ini adalah 31 perusahaan perbankan yang tercatat di Bursa Efek Indonesia periode 2007-2010. Teknik sampling yang digunakan di sini adalah purposive sampling dengan kriteria (1) perusahaan yang memiliki laporan keuangan tahun 2007-2010, (2) perusahaan yang tidak melakukan merger dan aktivitas akuisisi (3) membagikan dividen minimal 3 periode selama periode penelitian 2007-2010 (4) tidak disuspen selama periode penelitian. Data ini diperoleh berdasarkan pada Direktori Pasar Modal Indonesia (ICMD 2010) yang publikasi, website perusahaan tersebut dan IDX. Diperoleh jumlah sampel 10 perusahaan dari 31 perusahaan perbankan yang terdaftar di Bursa Efek Indonesia. Teknik analisis yang digunakan disini adalah regresi berganda dengan Generalized least Square dan uji hipotesis menggunakan t-statistik untuk menguji koefisien regresi parsial dan F-statistik untuk menguji pengaruh secara bersama-sama dengan tingkat kepercayaan 5%. Hasil Penelitian menunjukkan bahwa Asset Turnover (ATO) memberikan efek signifikan positif pada Dividen Payout Ratio (DPR). Dalam penelitian ini juga ditemukan Debt To Equity Ratio (DER) memberikan efek negatif yang signifikan pada Dividen Payout Ratio (DPR). Variabel lain yaitu Laba Bersih Margin (NPM) tidak berpengaruh signifikan terhadap DPR. Kami menyarankan bagi investor di Bursa Efek Indonesia yang tujuannya untuk mendapatkan dividen harus memberikan perhatian lebih untuk informasi yang diterbitkan oleh perusahaan, karena dengan informasi tersebut mereka dapat membuat keputusan yang terbaik untuk investasi mereka. Pada penelitian ini, Debt to equit Ratio (DER) menunjukkan variabel yang paling mempengaruhi terhadap DPR yang ditunjuk oleh jumlah nilai koefisien beta standar - 4,873054, Net Profit Margin (NPM) - 0,580157 dan Asset Turnover (ATO) 0,707340
Silica Gels Doped with Gold Nanoparticles: Preparation, Structure and Optical Properties

A novel, one-pot sol–gel preparation scheme leading to reproducible incorporation of 20–40 nm sized gold nanoparticles (AuNPs) in SiO2 gels is developed based on in situ reduction during gelation using chloroauric acid and ascorbic acid. Variation in the preparation conditions affects the chemical composition, optical properties and size distribution of the AuNPs incorporated in the silica gels. Different organic dopants, i.e., oleic acid, acetic acid or dodecanethiol, are applied to modify the final composite material and to control the rate of reduction and growth of the AuNPs in the gels. The synthesized samples are characterized by UV/Vis/NIR spectroscopy, X-ray diffraction, transmission electron microscopy, thermal conductivity measurements and DTA/TG measurements. The optical properties of the obtained composites are explained using Mie theory. The incorporation of AuNPs leads to an increase in the thermal conductivity of the silica gels. The best process method in this contribution is the use of NaOH as a gelation catalyst and oleic acid as an organic modifier, leading to 20 nm AuNPs dispersed in the silica matrix.
Clinical efficacy and drug resistance of ceftazidime-avibactam in the treatment of Carbapenem-resistant gram-negative bacilli infection

Objective To examine the clinical efficacy, safety, and resistance of Ceftazidime-Avibactam (CAZ-AVI) in patients with Carbapenem-resistant Gram-negative bacilli (CR-GNB) infections. Methods We retrospectively analyzed relevant data of CR-GNB infected patients receiving CAZ-AVI treatment, analyzed relevant factors affecting drug efficacy, and compared the efficacy and safety with patients receiving Polymyxin B treatment. Results A total of 139 patients were included. Agranulocytosis, septic shock, SOFA score, and CAZ-AVI treatment course were independent risk factors affecting the prognosis of patients with CR-GNB infection treated with CAZ-AVI while prolonging the treatment course of CAZ-AVI was the only protective factor for bacterial clearance. The fundamental indicators showed no statistically significant differences between CAZ-AVI and Polymyxin B treatment groups. At the same time, the proportion of patients treated with monotherapy was significantly higher in the CAZ-AVI group than in the Polymyxin B group (37.2% vs. 8.9%, p < 0.05), the 30-day mortality rate of the CAZ-AVI treatment group (27.7% vs. 46.7%, p = 0.027) was lower than that of the Polymyxin B treatment group. The 30-day clinical cure rate (59.6% vs. 40% p = 0.030) and 14-day microbiological clearance rate (42.6% vs. 24.4%, p = 0.038) were significantly higher in the CAZ-AVI than in the Polymyxin B treatment group. Eighty nine patients were monitored for CAZ-AVI resistance, and the total resistance rate was 14.6% (13/89). The resistance rates of Carbapenem-resistant Klebsiella pneumoniae (CRKP) and Carbapenem-resistant Pseudomonas aeruginosa (CRPA) to CAZ-AVI were 13.5 and 15.4%, respectively. Conclusion CAZ-AVI has shown high clinical efficacy and bacterial clearance in treating CR-GNB infections. Compared with Polymyxin B, CAZ-AVI significantly improved the outcome of mechanical ventilation in patients with septic shock, agranulocytosis, Intensive Care Unit (ICU) patients, bloodstream infection, and patients with SOFA score > 6, and had a lower incidence of adverse events. We monitored the emergence of CAZ-AVI resistance and should strengthen the monitoring of drug susceptibility in clinical practice and the rational selection of antibiotic regimens to delay the onset of resistance.
Les cadres intermédiaires et l’information : modélisation des comportements informationnels de cadres intermédiaires d’une municipalité en transformation

Conseil de recherches en sciences humaines du Canada (CRSH), Fonds quebecois de recherche sur la societe et la culture (FQRSC), Manulife Financial Corporation, Fondation J.A. DeSeve, Faculte des etudes superieures de l’Universite de Montreal (bourse de fin d’etudes), EBSI/Faculte des etudes superieures de l’Universite de Montreal (bourses conjointes)
Biofilm Removal from In Vitro Narrow Geometries Using Single and Dual Pulse Er:YAG Laser Photoacoustic Irrigation

The disinfection and removal of biofilm from titanium dental implants remains a great challenge in oral medicine. Here we present results of novel photoacoustic irrigation laser modalities for biofilm removal in model geometries mimicking the peri-implant pocket. The efficacy of single pulse (Er:YAG-SSP) and dual pulse (Er:YAG-AutoSWEEPS) photoacoustic irrigation modalities were determined for Enterococcus faecalis biofilm decontamination from titanium surfaces in narrow cylindrical and square gap geometries. The density of bacteria as well as the number of live bacteria were determined prior and after different photoacoustic treatments. Both SSP and AutoSWEEPS photoacoustic irrigation techniques removed at least 92% of biofilm bacteria during the 10 s photoacoustic treatment. The effectiveness of cleaning was better in the narrow square gap geometry compared to the cylindrical geometry. The dual pulse Er:YAG-AutoSWEEPS photoacoustic irrigation showed better results compared to SSP modality. No chemical adjuvants were needed to boost the effectiveness of the photoacoustic irrigation in the saline solution. The results imply that photoacoustic irrigation is an efficient cleaning method for debridement and decontamination in narrow geometries and should be considered as a new therapeutic option for the treatment of peri-implant diseases.
Point-of-Care Ultrasonography in Internal Medicine: Limitations and Pitfalls for Novice Users

Point-of-care ultrasound (POCUS) is increasingly being adopted in the field of internal medicine, leading to the development of POCUS curricula in undergraduate and postgraduate medical education programs. Prominent internal medicine societies and organizations worldwide recognize the expanding utilization of POCUS by internal medicine physicians, emphasizing the need for practitioners to be aware of both its benefits and limitations. Despite the growing enthusiasm for POCUS, clinicians, particularly those with limited clinical experience, must be cautious regarding its inherent limitations and the potential impact on their clinical practice. This review aims to outline the limitations and potential drawbacks of POCUS for medical students, residents, and internists who wish to stay abreast of the escalating use of POCUS in internal medicine and have a desire, or have already commenced, to incorporate POCUS into their practice. Additionally, it provides recommendations for enhancing POCUS proficiency to mitigate these limitations.
Endocytosis and Endocytic Motifs across the Connexin Gene Family

Proteins fated to be internalized by clathrin-mediated endocytosis require an endocytic motif, where AP-2 or another adaptor protein can bind and recruit clathrin. Tyrosine and di-leucine-based sorting signals are such canonical motifs. Connexin 43 (Cx43) has three canonical tyrosine-based endocytic motifs, two of which have been previously shown to recruit clathrin and mediate its endocytosis. In addition, di-leucine-based motifs have been characterized in the Cx32 C-terminal domain and shown to mediate its endocytosis. Here, we examined the amino acid sequences of all 21 human connexins to identify endocytic motifs across the connexin gene family. We find that although there is limited conservation of endocytic motifs between connexins, 14 of the 21 human connexins contain one or more canonical tyrosine or di-leucine-based endocytic motif in their C-terminal or intracellular loop domain. Three connexins contain non-canonical (modified) di-leucine motifs. However, four connexins (Cx25, Cx26, Cx31, and Cx40.1) do not harbor any recognizable endocytic motif. Interestingly, live cell time-lapse imaging of different GFP-tagged connexins that either contain or do not contain recognizable endocytic motifs readily undergo endocytosis, forming clearly identifiable annular gap junctions when expressed in HeLa cells. How connexins without defined endocytic motifs are endocytosed is currently not known. Our results demonstrate that an array of endocytic motifs exists in the connexin gene family. Further analysis will establish whether the sites we identified in this in silico analysis are legitimate endocytic motifs.
Metabolic and molecular effects of dietary extra virgin olive oil in blood and placenta of women with GDM

Gestational diabetes mellitus (GDM) increases the risks of maternal, placental, and neonatal complications. Previously, we found that a diet enriched in extra virgin olive oil (EVOO) prevents increased maternal triglyceridemia and placental proinflammatory markers in a cohort of GDM patients. The aim of this work was to evaluate maternal circulating markers of insulin resistance, placental collagen, glycogen and lipid levels, and placental levels of proteins, mRNAs, and a microRNA involved in the endocytic pathway in the same cohort of control women and women with GDM who received or did not receive a diet enriched in EVOO (36 g/day) from weeks 24 to 28 of pregnancy until term. Results At term, the TG/HDL cholesterol ratio, fatty acid binding protein 4 circulating levels, and maternal BMI were increased in the GDM patients, alterations prevented by the maternal diet enriched in EVOO. Although there were no changes in placental lipid levels and lipid profile, GDM placentas were thicker than controls and showed increased glycogen and collagen content, alterations prevented by the EVOO enriched diet. GDM placentas showed increases in megalin levels, in the expression of several genes involved in the endocytic pathway, and in miR-199, which targets these genes, alterations prevented by the maternal diet enriched in EVOO. Conclusions We identified novel beneficial effects of an EVOO-enriched diet in GDM women, a diet capable of regulating maternal insulin resistance, the structure and metabolism of the placenta, and the placental endocytic pathway, suggesting effects that may be beneficial for fetal development.
Differential Expression of Subsets of Genes Related to HDL Metabolism and Atherogenesis in the Peripheral Blood in Coronary Artery Disease

Differential expression of genes (DEGs) in coronary artery disease (CAD) and the association between transcript level and high-density lipoprotein cholesterol (HDL-C) were studied with 76 male patients with CAD and 63 control patients. The transcript level of genes related to HDL metabolism (24 genes) and atherosclerosis-prone (41 genes) in RNA isolated from peripheral blood mononuclear cells was measured by real-time RT-PCR. Twenty-eight DEGs were identified. The expression of cholesterol transporters, ALB, APOA1, and LCAT was down-regulated, while the expression of AMN, APOE, LDLR, LPL, PLTP, PRKACA, and CETP was up-regulated. The systemic inflammation in CAD is evidenced by the up-regulation of IL1B, TLR8, CXCL5, and TNFRSF1A. For the controls, TLR8 and SOAT1 were negative predictors of the HDL-C level. For CAD patients, PRKACG, PRKCQ, and SREBF1 were positive predictors, while PRKACB, LCAT, and S100A8 were negative predictors. For CAD patients, the efficiency of reverse cholesterol transport is 73–79%, and intracellular free cholesterol seems to accumulate at hyperalphalipoproteinemia. Both atheroprotective (via S100A8) and proatherogenic (via SREBF1, LCAT, PRKACG, PRKACB, and PRKCQ) associations of gene expression with HDL-C determine HDL functionality in CAD patients. The selected key genes and involved pathways may represent HDL-specific targets for the diagnosis and treatment of CAD and atherosclerosis.
Efficacy of Personalized Foot Orthoses in Children with Flexible Flat Foot: Protocol for a Randomized Controlled Trial

Pediatric flat foot (PFF) is a very frequent entity and a common concern for parents and health professionals. There is no established definition, diagnostic method, or clear treatment approach. There are multiple conservative and surgical treatments, the implantation of foot orthoses (FO) being the most used treatment. The evidence supporting FO is very thin. It is not clearly known what the effect of these is, nor when it is convenient to recommend them. The main objective of this protocol is to design a randomized controlled trial to determine if personalized FO, together with a specific exercise regimen, produce the same or better results regarding the signs and symptoms of PFF, compared to only specific exercises. In order to respond to the stated objectives, we have proposed a randomized controlled clinical trial, in which we intend to evaluate the efficacy of FO together with strengthening exercises, compared to a control group in which placebos will be implanted as FO treatment along with the same exercises as the experimental group. For this, four measurements will be taken throughout 18 months (pre-treatment, two during treatment and finally another post-treatment measurement). The combination of FO plus exercise is expected to improve the signs and symptoms (if present) of PFF compared to exercise alone and the placebo FO group. In addition, it is expected that in both conditions the biomechanics of the foot will improve compared to the initial measurements.
Comparative study of some agricultural treatments effects on plant growth, yield and chemical constituents of some fennel varieties under Sinai conditions.

Two field trails were conducted during 2002 and 2003 seasons at the research farm of Desert Research Center, (El-Maghara – North Sinai Governorate). Two experiments have been done. The first was to study the effect of bio and organic fertilization separately or combined with the addition of chemical fertilization. The second, was to study the effect of irrigation levels (2,4 and 8L/hour) on growth, yield, some chemical compositions and both essential oil percentage and constituents of some fennel varieties (Foeniculum vulgare var. vulgare Mill. and Foeniculum vulgare var. azoricum Mill.) Twelve treatments were used; to investigate effect of fertilization and three treatments were used to investigate the effect of irrigation levels. The results showed that in most cases, local or bitter variety (Foeniculum vulgare var. vulgare Mill.) was superior to sweet or German one (Foeniculum vulgare var. azoricum Mill.). Generally high chemical fertilization level combined with both bio and organic fertilizers (Bio + Organic + 300kg/feddan ammonium sulphate + 300kg/feddan calcium super phosphate + 100kg/feddan potassium sulphate) increase plant growth, essential oil and chemical constituents. Using (8L/h) dripper or high irrigation rate, generally, gave the best results.
Application of machine learning for financialization modeling

Research objective: The objective of this article is to present the application of machine learning techniques in modeling the phenomenon of financialization and analyze their effectiveness in predicting and understanding this phenomenon. Methodology: The methodology is based on data collection and processing from various sources. Subsequently, machine learning techniques such as regression, classification, decision trees, and neural networks were applied to train predictive models and analyze the phenomenon of financialization. Main conclusions: Data analysis using machine learning techniques allowed for the identification of key factors and patterns related to financialization. It has been demonstrated that machine learning models can effectively predict financialization trends and provide insight into the mechanisms and factors influencing this phenomenon. Application of the study: The study has significant implications for various fields, such as economics, finance, and economic policy. The application of machine learning techniques in modeling financialization can aid in making better investment decisions, assessing risk, monitoring financial stability, and developing more effective regulatory strategies. Originality/Novelty of the study: This article contributes an original perspective to the scientific literature by focusing on the application of machine learning techniques in the context of financialization. The work presents a new insight into this phenomenon and provides evidence of the effectiveness of machine learning-based models in analyzing and forecasting financialization.
STUDIES ON TOXICITY EVALUATION OF DIMETHOATE ON THE FRESHWATER FISH RASBORA DANICONUS WITH SPECIAL REFERENCE TO THE GILL HISTOPATHOLOGY

: The acute toxicity bioassay of dimethoate was carried out by the probit analysis method. The 24, 48, 72 and 96 h LC50 values were obtained as 11.63, 10.08, 10.54 and 9.136 ppm respectively. In the present investigation the effect of dimethoate on the gill of Rasbora daniconius at 96 hours LC50 marked histopathological changes found like degeneration of epithelium of secondary gill lamellae, vacuolation, fusion, shortening of secondary gill lamellae, thickness and fusion of primary and secondary gill lamellae
Cover Crop Yield, Nutrient Storage and Release under Different Cropping Technologies in the Sustainable Agrosystems

Due to short post-harvest seasons, it is not always possible to grow worthy cover crops (CCs). This research aims to clarify the impact of undersown red clover (Trifolium pratense L., RC) and post-sown white mustard (Sinapis alba L., WM) management on their biomass, accumulated nitrogen (N), phosphorus (P), and potassium (K) content and the nutrient release to subsequent main crops. During the study period, RC mass yields varied from 220 to 6590 kg ha−1 DM and those of WM from 210 to 5119 kg ha−1 DM. WM shoot biomass increased with the increase in rainfall in August and the average daily temperature of the post-harvest period. CC productivity and efficiency were higher when growing short-season spring barley than winter wheat. In the warm and rainy post-harvest period, undersown WM after winter wheat increased the biomass by 34.1% compared to post-harvest sowing. The application of straw (+N) increased the accumulation of nutrients in WM biomass. The intensive fertilization of the main crop had a negative effect on RC yield and NPK accumulation. RC shoot biomass was characterized by a higher N content and WM by a higher P concentration. Well-developed CCs could reduce soil mineral nitrogen content by 28.5–58.8% compared to a plot without CCs. Nutrient transfer to spring barley was dependent on the N content of CC biomass and the carbon and nitrogen ratio (C:N < 20). We conclude that CC growth and efficiency were enhanced by the investigated measures, and in interaction with meteorological conditions.