Miracle-dz/UniFAR-FTUs huggingface dataset:
for effects of in the relationship between

Mindfulness originated in the Buddhist tradition as a way of cultivating clarity of thought. Despite the fact that this behavior is best captured using critical thinking (CT) assessments, no studies have examined the effects of mindfulness on CT or the mechanisms underlying any such possible relationship. Even so, mindfulness has been suggested as being beneﬁcial for CT in higher education. CT is recognized as an important higher-order cognitive process which involves the ability to analyze and evaluate evidence and arguments. Such non-automatic, reﬂective responses generally require the engagement of executive functioning (EF) which includes updating, inhibition, and shifting of representations in working memory. Based on research showing that mindfulness enhances aspects of EF and certain higher-order cognitive processes, we hypothesized that individuals higher in facets of dispositional mindfulness would demonstrate greater CT performance, and that this relationship would be mediated by EF. Cross-sectional assessment of these constructs in a sample of 178 university students was achieved using the observing and non-reactivity sub-scales of the Five Factor Mindfulness Questionnaire, a battery of EF tasks and the Halpern Critical Thinking Assessment. Our hypotheses were tested by constructing a multiple meditation model which was analyzed using Structural Equation Modeling. Evidence was found for inhibition mediating the relationships between both observing and non-reactivity and CT in different ways. Indirect-only (or full) mediation was demonstrated for the relationship between observing, inhibition, and CT. Competitive mediation was demonstrated for the relationship between non-reactivity, inhibition, and CT. This suggests additional mediators of the relationship between non-reactivity and CT which are not accounted for in this model and have a negative effect on CT in addition to the positive effect mediated by inhibition. These ﬁndings are discussed in the context of the Default Interventionist Dual Process Theory of Higher-order Cognition and previous studies on mindfulness, self-regulation, EF, and higher-order cognition. In summary, dispositional mindfulness appears to facilitate CT performance and this effect is mediated by the inhibition component of EF. However, this relationship is not straightforward which suggests many possibilities for future research.
Acceptability of the taste of low sodium preparations with salt substitutes in diabetic and hypertensive patients

INTRODUCCIÓN La dieta es uno de los factores determinantes de la prevención, mejoramiento de la salud y calidad de vida de las personas (1). Los consumidores reportan que el gusto es un elemento decisivo e importante para la selección de los alimentos y que la variación en la percepción del sabor de la sal se asocia con diferencias en las respuestas hedónicas (grados de gusto o disgusto que se utilizan en las pruebas de aceptabilidad y preferencia) (2) a los alimentos altos en sodio y por lo tanto la ingesta de sodio (3). El Perú muestra una evidente heterogeneidad en el perfil de la hipertensión y diabetes. En el 2015, se encontró que la prevalencia estandarizada por edad de la prehipertensión y la hipertensión fue 23,7 % y 16,2 % respectivamente y para el caso de prediabetes y diabetes mellitus fue 18.1% y 6.2% (4). La hipertensión es una comorbilidad frecuente de la diabetes mellitus y en el caso de la diabetes de tipo 2 es parte del Rev Chil Nutr Vol. 43, No4, 2016
Development and properties of a new doxorubicin carrier based on surface-modified iron zero-valent microparticles with high encapsulation efficiency and the possibility of its controlled release

Currently, chemotherapy combined with surgery and radiation therapy is the most effective treatment for cancer. At the same time, the use of this method is accompanied by serious side effects caused by the lack of specificity of most chemotherapeutic agents. In this regard, the development of drug delivery systems (DDS) capable of addressing a chemotherapeutic agent to cancer cells, as well as its controlled release, is a promising approach for the effective treatment of cancer. The aim of the study is to synthesize a new DDS based on surface-modified microparticles of zero-valent iron, to study its properties as a carrier of a chemotherapeutic agent (encapsulation efficiency, loading capacity, possibility of controlled release of a chemotherapeutic agent) and safety. Materials and methods. The microparticles were synthesised by reduction of iron (III) chloride with sodium borohydride followed by in situ surface modification by 4-carboxybenzyldiazonium tosylate. microparticles demonstrated high encapsulation efficiency, drug loading capacity of DOX (0.9 mg per 1 mg of Fe-CS microparticles), low cytotoxicity and also a possibility to modulate the release rate by ultrasound irradiation and by changing pH of the external environment. Conclusion. A carrier based on microparticles of zero-valent iron with covalently attached to the surface chitosan (Fe-CS) was obtained. The efficiency of encapsulation, the loading capacity of doxorubicin was determined and the possibility of its controlled release under the influence of an ultrasonic field at different pH values was confirmed. In an in vitro experiment on the HeLa cell line (ATCC® CCL¬2™), no toxicity was established for all samples (Fe 0 , Fe-COOH и Fe-CS), regardless of their concentration.
ANTIBACTERIAL ACTIVITY OF MEDICINAL PLANT EXTRACTS OF AGERATUM CONYZOIDES

The plant Ageratum conyzoides is widely used in folk medicine in the Villages in west UP and Uttarakhand, India. The aim of this study is evaluate the anti bacterial study of the n-hexane, Chloroform, ethyl acetate, methanol and water extract of the Ageratum conyzoides (Linn.) leaves belonging to family Asteraceae were investigated against Two Gram positive bacteria like Staphylococcus aureus and streptococcus pneumoniae as well as Three Gram negative bacteria like Escherichia coli, Pseudomonas aeruginosa and klebisella pneumoniae. Because of such concerns, the necessity to find potentially fruitful, healthy safer and natural alternative preservatives is increased. Plant extracts have been used to control food poisoning defect and preserve foodstuff. Agar disc diffusion techniques were used for in-vitro antibacterial Screening. Methanolic extract was potentially effective with variable efficiency against the tasted four bacterial stains Staphylococcus aureus, streptococcus pneumoniae, Pseudomonas the lowest plant extract concentration at dilution that completely bacterial growth. The test dilutions further sub-cultured on fresh solid media and incubated for 18 h to determine the MBC values. The lowest plant extract concentration that killed all the bacteria was defined as MBC. Tests were carried out in triplicate to test each dilution for each bacterial strain to determine MIC values. AGMOG- AGWAT- Sp- streptococcus pneumoniae, klebisella pneumoniae,
A Proof of Theorem 1

where W and Z represent the random 3D point clouds with k points subsampled from T and T ∗ uniformly at random without replacement, respectively. We use Φ to denote the joint space of W and Z, where each element is a 3D point cloud with k points subsampled from T or T ∗. We denote by E the set of intersection points between T and T ∗, i.e., E = T ∩ T ∗. Before proving our theorem, we first describe a variant of the Neyman-Pearson Lemma [21] that will be used in our proof. The variant is from [9].
Function Point Analysis with Model Driven Architecture Applied on Frameworks of Partial Code Generation

— Software measurement is a crucial task for the planning and the developing of information systems. The Function Point Analysis (FPA) was developed to measure the complexity of the functionality of systems. Its methods are independent of technology and can be applied directly to the specification of features and the domain. However, the counting should be performed by a metrics analyst, being under subjectivity, wasting time and a large number of resources. This article describes the proposal of automation of function point counting performed using Unified Modeling Language (UML) models and Model Driven Architecture (MDA) methodology. Our approach provides a standard method for counting based on the International Function Point Users Group (IFPUG), eliminating the subjectivity present in traditional procedures. The work counts the number of realized function points, based on the information system already developed. The counting of function points achieved allows for transparency to the client receiving the product besides the construction of an important historical base for the refinement of future estimates.
Dynamic Codec Selection Algorithm for VoIP

— This paper gives a proposal on algorithm for adaptive adjustment of VoIP sources transmission rate based on voice quality estimated at the receiver. This adjustment is achieved through the appropriate use of differing voice codecs, as changes in network conditions occur, in order to maintain an efficient utilization of the available resources. We propose a simple algorithm for dynamic selection of voice codec, depending on network conditions during the on-going voice session. Algorithm is embedded in the source code of the programming environment OPNET Modeler 14.5. Simulation results show that the proposed algorithm makes better use of the available bandwidth, achieving superior performance in comparison to the situation without implementation of algorithm for adaptive codec selection.
Multiple Fano resonances Based on the Rectangular cavity resonator and crescent-shaped cavity resonator

: World is rich in unconventional oil and various alternatives to petroleum. However, conventional oil production declines so quickly that it is likely these unconventional oil resources cannot be put into production fast enough, and thus will not be compensated sufficiently. We realize detecting rapid detection of water content in heavy oil. The waveguide consists of a metal-insulator-metal (MIM) waveguide, rectangular cavity resonator, and crescent-shaped cavity resonator. The effects of the coupling distance, geometry of the crescent-shaped cavity resonator and its rotation angle, and length and width of the rectangular cavity resonator on the Fano resonance lines were numerically analyzed. Multiple Fano resonances can be produced as the rotation angle of the crescent-shaped cavity resonator is adjusted, and the sensor’s refractive index sensitivity was found to be 935.71 nm/RIU . By measuring the water content in heavy oil, we found that the Fano resonance lines shift toward shorter wavelengths as the volume fraction of water content increases. The detection resolution in heavy oil 1.79 × 10 −9 . The results presented here show that water content in heavy oil can be calculated using the measured change in the Fano resonance wavelength.
EB_A_297274 89..97

1Department of Neuroscience/ Ophthalmology, Uppsala University, Uppsala, Sweden; 2Department of Ophthalmology, University Hospital Basel & University Basel, Basel, Switzerland; 3Department of Biomedicine, University Hospital Basel & University Basel, Basel, Switzerland; 4Department of Ophthalmology, San Bassiano Hospital, Bassano del Grappa, Italy; 5Department of Medicine, Private University of the Principality of Lie Triesen, Triesen, Liechtenstein; 6Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland; 7Department of Neuroradiology, Cantonal Hospital Aarau, Aarau, Switzerland Objective: To report on the lipocalin-type prostaglandin D synthase (L-PGDS) concentrations in the cerebrospinal fluid (CSF) of the perioptic and lumbar subarachnoid space (SAS) in patients with radiologically proven optic nerve (ON) sheath compartmentation presenting as normal-tension glaucoma (NTG). Methods: Retrospective biochemical analysis of CSF in thirteen patients with ON sheath compartmentation presenting as NTG (four females, mean age 70±8 years). CSF was sampled from the SAS of the ON during ON sheath fenestration for ON sheath compartmentation and from the lumbar SAS at the time of lumbar puncture. Nephelometry was used for the quantification of L-PGDS and albumin concentration. Albumin was measured in order to assess the amount of contamination with serum in the CSF samples taken from the ON SAS. Main outcome measures were L-PGDS concentrations in the CSF of the perioptic and lumbar SAS. Results: Mean L-PGDS concentration was 24±8 mg/L in the lumbar SAS compared to 33 ±27 mg/L without correction of serum contamination and 45±39 mg/L after correction of serum contamination in the perioptic SAS. The difference between the lumbar and the perioptic SAS was statistically significant (P=0.0047 without correction of serum contamination, P=0.0002 with correction of serum contamination; Mann–Witney U-test). Conclusion: This study demonstrates a concentration gradient of L-PGDS levels within the CSF with a statistically significant higher concentration in the compartmentalized perioptic SAS compared to that in the lumbar SAS. Biochemical changes in the perioptic SAS might be involved in the pathophysiology in NTG patients with ON sheath compartmentation.
Electrochemical Determination of Ascorbic Acid Using Modified Glassy Carbon Electrode by Multiwall Carbon Nanotube-Nafion in Chloroacetic Acid Media

In this study, ascorbic acid was simply determined at lower potential compared to bare glassy carbon by replacement phosphate buffer solution with chloroacetate buffer solution at surface of modified glassy carbon electrode. A film of Nafion with multi-walled carbon nanotubes (MWCNT) was prepared by rapidly casting solution onto the surface of a glassy carbon electrode and drying under room temperature. For MWCNT-Nafion film was not observed any peaks in the used potential range in phosphate buffer solution. However, by replacing phosphate buffer solution with chloroacetate buffer solution, due to interaction between nafion film and component of chloroacetate buffer solution in a positive scan, an oxidation peak was obtained at about 0.442 V and at a reversal scan a reduction peak was observed at about 0.282 V. Scan rate, pH and interference effects for the determination of ascorbic acid were studied. It was found that glassy carbon electrode/MWCNT-Nafion in chloroacetate buffer solution pH = 2, increase significantly the cyclic voltammogram peak currents as well as a decreasing the oxidation overpotentials of ascorbic acid compared to bare glassy carbon. A linear range between 5.0 × 10 -5 mol/L and 2.32 × 10 -2 mol/L and a detection limit (3 σ ) 1.2 × 10 -5 mol/L was obtained for modified electrode. Finally, the novel modified electrode was successfully applied to the determination of ascorbic acid in pharmaceuticals and foods in acetate medium.
The Italian Guillain–Barre´ Study Group. The prognosis and main prognostic indicators of Guillain–Barre´ syndrome: a multicentre prospective study of 297 patients

From their commendably large prospective hospital-based study of 297 patients with Guillain–Barre´ syndrome, the Italian Guillain–Barre´ Study Group (1996) conclude that age, antecedent gastroenteritis, disability and electrophysiological signs of axonopathy are adverse prognostic factors. An unusually high proportion of their patients (27/93, 29% of those studied electrophysiologically) had axonal neuropathy or inexcitable nerves. The proportion of patients with axonal neuropathy or inexcitable nerves in a recent international trial was only 22/370 (5.9%) (Plasma Exchange/Sandoglobulin Guillain–Barre´ Syndrome Trial Group, 1997). Possible reasons for the difference include the use, in the Plasma Exchange/Sandoglobulin Guillain–Barre´ Syndrome Trial, of the stricter criteria for axonopathy of Ho et al . (1995) and the performance of all nerve conduction studies within 15 days from the onset of symptoms. It would be helpful to know when, in relation to the onset of neuropathy, the nerve conduction tests were performed in the Italian study, since, if it was later, axonal degeneration would have been more likely to have occurred and to have led to the patient being classiﬁed as having an axonal neuropathy or inexcitable nerves. In the Plasma Exchange/Sandoglobulin Guillain– Barre´ Syndrome Trial, electrophysiological evidence of axonopathy was not associated with an increased likelihood of being unable to walk unaided after 48 weeks,
Jak mravenčí kolonie dobývají znalosti

Mezi nova řeseni klasifikacnich uloh patři přistupy inspiro- vane socialnim chovanim spolecenstev hmyzu - vcel, termitů nebo mra- venců. V teto praci přinasime kritickou analýzu systemu Ant-Miner a uvadime jeho vylepsenou verzi. Uvadime nejprve analýzu casove naroc- nosti původniho algoritmu GUI Ant-Miner. Ukažeme, že datova sada Wisconsin Breast Cancer použita pro experimenty ve vsech předcho- zich publikovaných clancich neni vhodna. Pote popiseme novou verzi, Ant-Miner+, vcetně noveho pravidla pro urceni kvality naucených dat. Uvadime výsledky experimentů s timto systemem a porovnani s jinými ucicimi algoritmy.
Alternative splicing of HDMX predicts p53 inactivation and bad prognosis

Tumour suppressor p53 is functionally attenuated in virtually all human tumours. In osteosarcoma, only ~20% of tumours contain a p53 mutation and 10-35% has amplification of p53-inhibitor HDM2 (MDM2), suggesting alternative p53-inhibiting mechanisms in the remaining tumours, such as overexpression of another p53 inhibitor, HDMX (MDMX/MDM4). An oncogenic function of HDMX in other tumour types has been shown. Expression of an alternative HDMX splice variant ( HDMX-S ) is correlated with worse survival and high tumour grade in several tumour types. In this study we analyzed HDMX expression and alternative splicing in high-grade osteosarcomas and osteosarcoma cell lines. We found increased HDMX-S expression in a high number of osteosarcoma, correlating with shorter disease-specific survival and increased occurrence of metastases. Analysis of osteosarcoma cell lines showed a clear association of high HDMX-S expression with mutant or inactivated p53 and low HDMX protein expression. These findings were confirmed and validated in two independent panels of tumour cell lines, the NCI60 and a set of breast cancer cell lines. The clinical meaning of these findings was emphasized by the better prognostic value of the HDMX-S / HDMX-FL ratio than p53 mutational status in a cohort of soft tissue sarcoma patients. Using RNAi techniques to reduce HDMX levels in osteosarcoma cell lines, we observed a largely p53-independent growth inhibition and p53-dependent increased Nutlin-3-sensitivity. Furthermore, relatively high levels of full-length HDMX protein may be associated with cisplatin and doxorubicin resistance of osteosarcoma cells. Our results indicate a p53-independent role for HDMX in osteosarcomagenesis, whereas in later stage and clinically aggressive tumours a switch occurs towards the splice-variant HDMX-S , thereby reducing HDMX-FL protein levels. This altered ratio may serve as a new predictive biomarker for p53 inhibition in diverse tumour types.
A Linear Acceleration Emission Mechanism

Abstract A theory of linear acceleration emission, with possible application to pulsars, is developed. The equation of motion for a relativistic charged particle accelerated in the field of a longitudinal wave is solved to first order in the electric potential and used to derive the first order current. The power emitted and the absorption coefficient are calculated and the conditions under which masing can occur are discussed.
Filarial Parasite Clearance In Vivo Reverses Hyporesponsiveness and Leads to Removal of Regulatory T Cell Activity

Human ﬁlarial parasites cause chronic infection associated with long-term down-regulation of the host’s immune response. We show here that CD4 (cid:1) T cell regulation is the main determinant of parasite survival. In a laboratory model of infection, using Litomosoides sigmodontis in BALB/c mice, parasites establish for > 60 days in the thoracic cavity. During infection, CD4 (cid:1) T cells at this site express increasing levels of CD25, CTLA-4, and glucocorticoid-induced TNF receptor family-related gene (GITR), and by day 60, up to 70% are CTLA-4 (cid:1) GITR high , with a lesser fraction coexpressing CD25. Upon Ag stimulation, CD4 (cid:1) CTLA-4 (cid:1) GITR high cells are hyporesponsive for proliferation and cytokine production. To test the hypothesis that regulatory T cell activity maintains hyporesponsiveness and prolongs infection, we treated mice with Abs to CD25 and GITR. Combined Ab treatment was able to overcome an established infection, resulting in a 73% reduction in parasite numbers ( p < 0.01). Parasite killing was accompanied by increased Ag-speciﬁc immune responses and markedly reduced levels of CTLA-4 expression. The action of the CD25 (cid:1) GITR (cid:1) cells was IL-10 independent as in vivo neutralization of IL-10R did not restore the ability of the immune system to kill parasites. These data suggest that regulatory T cells act, in an IL-10-independent manner, to suppress host immunity to ﬁlariasis. The Journal of Immunology, 2005, 174: 4924–4933.
Amyloidogenicity of @A4 and BA4-bearing Amyloid Protein Precursor Fragments by Metal-catalyzed Oxidation*

Previously we have shown that the COOH-terminal 100 residues (A4CT) of the amyloid protein precursor (APP), which carry the sequence of the amyloid BA4 protein of Alzheimer’s disease at N-terminal position, form highly insoluble aggregates if expressed in the rabbit reticulocyte lysate and analyzed by sodium do- decyl sulfate-polyacrylamide gel electrophoresis (Dyrks, T., Weidemann, A., Multhaup, G., Salbaum, J. M., Lemaire, H.-G., Kang, J., Muller-Hill, B., Masters, C. L., and Beyreuther, K. (1988) EMBO J. 7, 949-967). Here we report that aggregation of this COOH-ter-minal APP fragment A4CT and also of BA4 itself de- pends on additional factors. In contrast to the reticulocyte expression system, expression of A4CT and BA4 in the wheat germ expression system resulted in only monomeric forms. We have identified the factors which are capable of transforming both soluble A4CT and BA4 into insoluble and aggregating molecules. Monomeric A4CT or BA4 expressed in the wheat germ lysate could be transformed into aggregating molecules by the addition of metal-catalyzed oxidation systems. The addition of radical scavengers such as ascorbic acid,
Strategic Voting at the Romanian 2008 Local Elections

The aim of this article is to measure the extent to which voters cast their ballots strategically at the Romanian 2008 local elections. Our interest was prompted by the introduction of a mixed-member electoral system for local elections. One common characteristic of mixed-member electoral systems is that they present the voter with the opportunity for strategic behavior. For the purpose of measuring strategic voting we use three methods: 1. we compare the number of votes received by candidates in the single member district race with the number of votes received by their parties in the proportional representation race; 2. we calculate the difference between the votes received by the two best ranked candidates to determine whether the race between the two was tight, which would stimulate strategic behavior; 3. we calculate the second-first ratio (SF-ratio) proposed by Gary Cox. Our results show that that only a small percentage of the voters behaved strategically although the newly introduced mixed-member electoral system presents them with the opportunity to do so.