Miracle-dz/UniFAR-FTUs huggingface dataset:
New procedures for discrete tests with proven false discovery rate control

We consider the problem of testing simultaneously many null hypotheses when the test statistics have a discrete distribution. We present new modifications of the Benjamini-Hochberg procedure that incorporate the discrete structure of the data in an appropriate way. These new procedures are theoretically proved to control the false discovery rate (FDR) for any fixed number of null hypotheses. A strong point of our FDR controlling methodology is that it allows to incorporate at once the discreteness and the quantity of signal of the data (so called "$\pi_0$-adaptation "). Finally, the power advantage of the new methods is demonstrated by using both numerical experiments and real data sets.
Mathematical Approach for Effect of Growth on the Mechanical Stresses during Soft Tissues and Avascular Tumor

In this Paper, the mathematical model for the study of the dis tribution of mechanical stresses by the cells within the sof t tissues and tumor tissue is discussed. To describe the impac t of isotropic growth on the mechanical stresses based on the linear elasticity theory and to study the process of continuous growth. Consti tutive law to describe a linearly elastic tumor with continu ous volume growth is combined in the model. Two examples is discussed, F irst case, in one dimensional model of tumor growth in rectan gular tube, The model is solved in terms of radial displacement and stres ses. In the second case, the effect of isotropic growth durin g a compressible material is solved in terms of radial displacement and stres es. The implications of two examples and possible model dev elopments are investigated. Comparisons are made with the results in t he two cases and numerical results are given and illustrated graphically for each case considered.
Cooperative robotic networks for underwater surveillance: an overview

Underwater surveillance has traditionally been carried out by means of surface and undersea manned vessels equipped with advanced sensor systems. This approach is often costly and manpower intensive. Marine robotics is an emerging technological area that enables the development of advanced networks for underwater surveillance applications. In contrast with the use of standard assets, these advanced networks are typically composed of small, low-power, and possibly mobile robots, which have limited endurance, processing and wireless communication capabilities. When deployed in a region of interest, these robots can cooperatively form an intelligent network achieving high performance with significant features of scalability, adaptability, robustness, persistence and reliability. Such networks of robots can be the enabling technology for a wide range of applications in the maritime domain. However, they also introduce new challenges for underwater distributed sensing, data processing and analysis, autonomy and communications. The main thrust of this study is to review the underwater surveillance scenario within a framework of four research areas: (i) underwater robotics, (ii) acoustic signal processing, (iii) tracking and distributed information fusion, and (iv) underwater communications networks. Progress in each of these areas as well as future challenges is presented.
Helicobacter Pylori and Celiac Disease Antibody Positivity Have a Higher Prevalence in Patients With Distal Gastrectomy: A Cross-Sectional Retrospective Study

Aims and objectives Distal gastrectomy was a widely used therapeutic option for peptic ulcer and gastroesophageal reflux disease until quite recently. The consequences of anatomical and physiological changes following surgery in the gastric mucosa have been the object of interest for the scientist. In this study, we aimed to determine whether Helicobacter pylori (HP) infection and celiac disease were more common in patients with a history of distal gastrectomy. Materials and methods This is an observational retrospective study conducted at Giresun University Faculty of Medicine. The medical files of 35 patients with dyspepsia who had a history of distal gastrectomy for benign etiologies (antrectomy group) and 50 patients with dyspepsia (control group) were retrospectively analyzed. Results There were more males and older patients in the antrectomy group. Concerning the lab parameters, platelets, lymphocyte, and albumin levels were significantly lower, and urea, creatinine, anti-Endomisium Ig A (anti-EMA), and anti-tissue transglutaminase IgA (anti-tTGA) antibody positivity were significantly higher in the antrectomy group. Gastric biopsy results revealed a higher positivity of HP, atrophy, neutrophil, and lymphocytes in the antrectomy group. Correlation analysis revealed an inverse correlation between albumin and anti-EMA/atrophy positivity whereas a positive correlation between anti-EMA and HP/atrophy positivity. Conclusions HP infection and coeliac disease (CD) could be the problems that distal gastrectomy patients with dyspepsia can face during their follow-up. Concerning the pre-malignant potential of HP, its screening and eradication should be performed to prevent the malignant transformation of the remnant gastric tissue.
Lecture on Hû astad's Switching Lemma

x11) is a DNF formula. Analogously, a CNF formula is a conjunction of terms, each of which is a disjunction of literals. The size of a DNF/CNF formula is the number of terms, and its width is the maximum number of literals in any term. A decision tree is a directed, acyclic graph with a designated start vertex having in-degree 0. Each vertex other than the leaves has out-degree two. Each non-leaf vertex is labeled with a variable, and has one outgoing edge labeled ‘0’ and one outgoing edge labeled ‘1’. Each leaf vertex is labeled either ‘0’ or ‘1’. A decision tree computes a function in the natural way. The depth of a decision tree is the maximum path length from the start to a leaf, and its size is the number of leaves. For a function f, we write DTdepth(f) to denote the smallest depth of any decision tree computing f. Note that any function on n variables always has DTdepth(f) ≤ n.
Supervisory adaptive fault‐tolerant control against actuator failures with application to an aircraft

In this paper, a supervisory adaptive fault‐tolerant control scheme is proposed for a class of uncertain nonlinear systems with multiple inputs. The multiple inputs are the outputs of an actuator group that may act either on one control surface or on multiple control surfaces and may fail during operation. With some actuator groups as backups, the supervisory adaptive control includes 2 modes: the adaptive compensation mode and the switching mode. The former is used to compensate for the failure of an actuator group as long as at least one actuator of the group works normally, and the latter, to switch the controller from a failed group to a healthy one when the failure is detected by one of the monitoring functions that are constructed to supervise some variables related to system stability. It is shown that with the proposed scheme, all signals of the closed‐loop system are bounded, and prescribed transient and steady state performance of the tracking error can be guaranteed. An aircraft example is used to demonstrate the application of the proposed scheme.
Fast Dissolving Drug Delivery Systems: A Brief Overview

Recently, fast-dissolving drug delivery systems have started gaining popularity and acceptance as new drug delivery systems, because they are easy to administer and lead to better patient compliance. Usually, elderly people experience difficulty in swallowing the conventional dosage forms (tablets, capsules, solutions and suspensions) because of tremors of extremities and dysphagia. Fast-dissolving drug delivery systems may offer a solution for these problems.
Penerapan Model Geographically Weighted Poisson Regression pada Jumlah Kematian Ibu di Provinsi Jawa Tengah

AbstrakKematian ibu menjadi salah satu indikator penting untuk menilai derajat kesehatan masyarakat di suatu wilayah. Kematian ibu diukur berdasarkan Angka Kematian Ibu (AKI). AKI di Provinsi Jawa Tengah cenderung meningkat setiap tahunnya. Untuk menurunkan AKI tersebut, perlu mengidenti? kasi keterkait- an kematian ibu dan faktor-faktor yang mempengaruhinya. Kasus kematian ibu dipengaruhi oleh kondisi geogra? s dan kejadiannya merupakan kejadian berdis- tribusi Poisson. Oleh karena itu, model yang sesuai untuk kasus kematian ibu adalah model geographically weighted poisson regression (GWPR). Model GWPR memerlukan pembobot dalam mengestimasi parameter mo- del. Pembobot menunjukkan hubungan antara satu wilayah dengan wilayah lain. Dalam penelitian ini dipilih pembobot fungsi kernel Gaussian dan bisquare karena kedua pembobot tersebut menggunakan unsur jarak antar wilayah. Tujuan dari penelitian ini adalah untuk menerapkan model GWPR dengan pembobot fungsi kernel Gaussian dan bisquare pada jumlah kematian ibu serta memilih model yang lebih baik menggunakan nilai Akaike Information Criterion (AIC ). Hasil penelitian ini diperoleh model yang berbeda untuk 35 kabupaten/kota di Provinsi Jawa Tengah, dan menunjukkan bahwa nilai AIC model GWPR de- ngan pembobot fungsi kernel bisquare sebesar 103.849. Nilai tersebut lebih ke- cil dari nilai AIC model GWPR dengan pembobot fungsi kernel Gaussian yaitu 113.0072, sehingga model GWPR dengan pembobot fungsi kernel bisquare lebihbaik untuk digunakan. Selain itu, diperoleh empat kelompok wilayah yang me-miliki faktor yang sama dan berpengaruh signi? kan terhadap jumlah kematianibu di Provinsi Jawa Tengah.Kata Kunci : Kematian ibu, GWPR, fungsi kernel Gaussian, fungsi kernel bi- square
Prevalence of Listeria monocytogenes in traditional cheeses obtained from food sale centers of Tehran, Iran

The bacteria Listeria monocytogenes can contaminate food and cause disease, not just in underdeveloped, but also in developed countries. Cheese is one of the dairy products that can cause listeriosis if it is consumed with contaminated milk. Sixty samples of traditional unpasteurized white cheese weighing approximately 100 g were obtained from sales centers in Tehran for three consecutive weeks. Then, 25 g of each weighed sample was added to 225 ml of initial enrichment medium and incubated at 30°C for 24 h. In the next step, they were cultured in Polymyxin Acriflavin Lithium-chloride Ceftazidime Esculin Mannitol medium and incubated at 35°C for 24 h. The growth and non-growth of Listeria monocytogenes bacterial colonies were examined, and additional tests were performed. The results of this study showed that out of 60 traditional cheese samples that were examined, based on the results of culture and supplementary tests, one cheese sample (1.6%) was infected with Listeria monocytogenes. In general, our study showed a lower level of contamination by Listeria monocytogenes compared to other studies. Iranian cheeses can be found in many varieties and there are differences in processing traditional cheese in different regions. Thereby, continuous monitoring is required.
Existence of Solutions to a Three-point Entrainment of Frequency Problem

In this paper, we deal with the existence of solutions to the f requency problem of a perturbed system, x′ − A(t)x = ε f (x,sinwt,coswt,ε) with three-point boundary condition. The topological tech nique is used to obtain existence theorem. Two examples are given to illustrate our results.
Enhanced Conduit Flow Compensates for the Reduction in Left Atrial Passive and Booster Functions in Advanced Diastolic Dysfunction

Background: Quantification of left atrial (LA) conduit function and its contribution to left ventricular (LV) filling is challenging because it requires simultaneous measurements of both LA and LV volumes. The functional relationship between LA conduit function and the severity diastolic dysfunction remains controversial. We studied the role of LA conduit function in maintaining LV filling in advanced diastolic dysfunction. Methods: We performed volumetric and flow analyses of LA function across the spectrum of LV diastolic dysfunction, derived from a set of consecutive patients undergoing multiphasic cardiac CT scanning (n=489). From LA and LV time-volume curves we calculated 3 volumetric components: 1) early "passive" emptying volume; 2) late "active" (booster) volume; and 3) conduit volume. Results were prospectively validated on a group of patients with severe aortic stenosis (n=110). Results: The early passive filling progressively decreased with worsening diastolic function (P<0.0001). The atrial booster contribution to stroke volume (SV) modestly increases in impaired relaxation (P<0.05) and declined with more advanced diastolic function (P<0.001), thus failing to compensate for the reduction in early filling. The conduit volume increased progressively (P<0.0001), accounting for 75% of SV (IQR 63-81%) with restrictive filling pattern, compensating for the reduction in both early and booster functions. Similar results were obtained in patients with severe aortic stenosis. The pulmonary artery systolic pressure increased in a near-linear fashion when the conduit contribution to SV increased above 60%. Maximal conduit flow rate strongly correlated with mitral E-wave velocity (r=0.71, P<0.0001), indicating that the increase in mitral E-wave in diastolic dysfunction represents the increased conduit flow. Conclusion: An increase in conduit volume contribution to SV represents a compensatory mechanism to maintain LV filling in advanced diastolic dysfunction. The increase in conduit volume despite increasing LV diastolic pressures is accomplished by an increase in pulmonary venous pressure.
Comparative Genomic Analysis Reveals Distribution, Organization and Evolution of Metal Resistance Genes in Genus Acidithiobacillus

14 Members of genus Acidithiobacillus which can adapt up to extremely high concentration of 15 AEM Accepted Manuscript Posted Online 2 November 2018 Appl. Environ. Microbiol. doi:10.1128/AEM.02153-18 Copyright © 2018 American Society for Microbiology. All Rights Reserved. on F ebuary 5, 2021 by gest ht://aem . sm . rg/ D ow nladed fom
Validación de un cuestionario de frecuencia de consumo de grupos de alimentos basado en un sistema de intercambios

Introduccion: la valoracion de la ingesta alimentaria se considera cada vez mas importante para relacionarla con el riesgo de enfermedad. Sin embargo, los cuestionarios de frecuencia de consumo de alimentos (CFCA) tradicionalmente utilizados requieren la dedicacion de gran cantidad de tiempo, tanto en la practica clinica como en estudios epidemiologicos de nutricion. Objetivo: el objetivo del presente estudio fue la validacion de un cuestionario de frecuencia de consumo de grupos de alimentos (CFCGA) basado en un sistema de intercambios, en relacion a un registro de pesada de alimentos (RPA) de 7 dias como referencia. Metodos: el estudio conto con 60 adultos sanos de ambos sexos. A cada uno, el dietista-nutricionista les recogio el CFCGA a validar y proporciono instrucciones para cumplimentar el RPA de 7 dias. Se calcularon los valores de energia y macronutrientes para ambos metodos y se aplicaron los metodos estadisticos mas apropiados. Resultados: los coeficientes de correlacion entre ambos metodos se hallaron entre r = 0,3 y r = 0,6 (p < 0,01) y los coeficientes de correlacion intraclase entre r = 0,2 y r = 0,6 (p < 0,01). El analisis de clasificaciones cruzadas revelo que mas del 80% de los individuos fueron clasificados en cuartiles identicos o contiguos por ambos metodos dieteticos. Conclusiones: el CFCGA propuesto, basado en un sistema de intercambios de 19 grupos, obtiene indices de validez comparables a otros modelos similares mas complejos para la valoracion de energia y macronutrientes, proporcionando un ahorro de tiempo.
Population sequencing data reveal a compendium of mutational processes in human germline

Mechanistic processes underlying human germline mutations remain largely unknown. Variation in mutation rate and spectra along the genome is informative about the biological mechanisms. We statistically decompose this variation into separate processes using a blind source separation technique. The analysis of a large-scale whole genome sequencing dataset (TOPMed) reveals nine processes that explain the variation in mutation properties between loci. Seven of these processes lend themselves to a biological interpretation. One process is driven by bulky DNA lesions that resolve asymmetrically with respect to transcription and replication. Two processes independently track direction of replication fork and replication timing. We identify a mutagenic effect of active demethylation primarily acting in regulatory regions. We also demonstrate that a recently discovered mutagenic process specific to oocytes can be localized solely from population sequencing data. This process is spread across all chromosomes and is highly asymmetric with respect to the direction of transcription, suggesting a major role of DNA damage.
Thermoelectric silicides: A review

Traditional research on thermoelectric materials focused on improving the figure-of-merit zT to enhance the energy conversion efficiency. With further growth and commercialization of thermoelectric technology beyond niche applications, other factors such as materials availability, toxicity, cost, recyclability, thermal stability, chemical and mechanical properties, and ease of fabrication become important for making viable technologies. Several silicide alloys were identified that have the potential to fulfill these requirements. These materials are of interest due to their abundancy in earth’s crust (e.g., silicon), non-toxicity, and good physical and chemical properties. In this paper, an overview of the silicide thermoelectrics from traditional alloys to advanced material structures is presented. In addition, some of the most effective approaches as well as fundamental physical concepts for designing and developing efficient thermoelectric materials are presented and future perspectives are discussed.
LARGE EDDY SIMULATION OF TURBULENT ROUND IMPINGING JET

Large Eddy Simulation (LES) approach (see e.g. [1]) has for the past decade proven to be the "mainstream" line in research of turbulence modelling. In LES the major part of the turbulent kinetic energy is resolved "directly" whereas the effects of remaining scales smaller than the computational grid size (filterwidth) are accounted in a subgrid-scale (SGS) model. Compared to well-known RANS (Reynolds-Averaged Navier-Stokes equations) approach, universality of LES is higher because in LES the model assumptions are made only on subgrid, energy-negligible scales of the turbulent flow. Another advantage of LES approach compared to RANS is that it shows the dynamics of large-scale fluctuations as in LES inherently the time-dependent solution is obtained. To separate the "resolved" scales of motion from the "smaller" scales that are to be modelled, the spatial filtering operation is used in LES where typically the computational grid cell size ∆ is associated with the filter width (i.e. the cutoff length at which the scales are separated) in the physical space [1]. When filtering is applied to the Navier-Stokes equations written in isothermal incompressible case, they take the following form:
Salt stress in Desulfovibrio vulgaris Hildenborough: An integrated genomics 1 approach.

: 23 Recent interest in the ability of Desulfovibrio vulgaris Hildenborough to reduce, and 24 therefore contain, toxic and radioactive metal waste, has made all factors that affect its 25 physiology of great interest. Increased salinity constitutes an important and frequent 26 fluctuation faced by D. vulgaris in its natural habitat. In liquid culture, exposure to excess 27 salt resulted in a striking cell elongation in D. vulgaris . Using data from transcriptomics, 28 proteomics, metabolite assays, phospholipid fatty acid profiling, and electron 29 microscopy, we undertook a systems approach to explore the effects of excess NaCl on 30 D. vulgaris . This study demonstrates that import of osmoprotectants such as glycine 31 betaine and ectoine constitute the primary mechanism used by D. vulgaris to counter 32 hyper-ionic stress. Several efflux systems were also highly up-regulated, as was the ATP 33 synthesis pathway. Increase in both RNA and DNA helicases suggested that salt stress 34 had affected the stability of nucleic acid base pairing. An overall increase in branched 35 fatty acids indicated changes in cell wall fluidity. An immediate response to salt stress 36 included up-regulation of chemotaxis genes though flagellar biosynthesis was down- 37 regulated. Other down-regulated systems included lactate uptake permeases and ABC 38 transport systems. The extensive NaCl stress analysis was compared with microarray data 39 from KCl stress and unlike many other bacteria, D. vulgaris responded similarly to the 40 two stresses. Integration of data from multiple methods has allowed us to present a 41 conceptual model for salt stress response in D. vulgaris that can be compared to other 42 microorganisms. 43
Saturated equiangular lines in Euclidean spaces

A set of lines through the origin in a Euclidean space is called equiangular when any pair of lines from the set intersects with each other at a common angle. We study the maximum size of equiangular lines in Euclidean space and use graph theoretic approach to prove that all the currently known construction for maximum equiangular lines in $\mathbb R^d$ cannot add another line to form a larger equiangular set of lines if $14 \leq d \leq 20$ and $d \neq 15$.
Robust Self-Supervised Extrinsic Self-Calibration

Autonomous vehicles and robots need to operate over a wide variety of scenarios in order to complete tasks efficiently and safely. Multi-camera self-supervised monocular depth estimation from videos is a promising way to reason about the environment, as it generates metrically scaled geometric predictions from visual data without requiring additional sensors. However, most works assume well-calibrated extrinsics to fully leverage this multi-camera setup, even though accurate and efficient calibration is still a challenging problem. In this work, we introduce a novel method for extrinsic calibration that builds upon the principles of self-supervised monocular depth and ego-motion learning. Our proposed curriculum learning strategy uses monocular depth and pose estimators with velocity supervision to estimate extrinsics, and then jointly learns extrinsic calibration along with depth and pose for a set of overlapping cameras rigidly attached to a moving vehicle. Experiments on a benchmark multi-camera dataset (DDAD) demonstrate that our method enables self-calibration in various scenes robustly and efficiently compared to a traditional vision-based pose estimation pipeline. Furthermore, we demonstrate the benefits of extrinsics self-calibration as a way to improve depth prediction via joint optimization. The project page: https://sites.google. com/tri.global/tri-sesc
Dataflow Dialogue Generation

We demonstrate task-oriented dialogue generation within the dataflow dialogue paradigm. We show an example of agenda driven dialogue generation for the MultiWOZ domain, and an example of generation without an agenda for the SMCalFlow domain, where we show an improvement in the accuracy of the translation of user requests to dataflow expressions when the generated dialogues are used to augment the translation training dataset.