Miracle-dz/UniFAR-FTUs huggingface dataset:
CIA_A_351431 223..234

1Department of Clinical Medicine, Trinity College Dublin, Dublin, Ireland; 2North Dublin Home Care (NDHC), Dublin, Ireland; 3School of Physiotherapy, RCSI University of Medicine and Health Sciences, Dublin, Ireland; 4Primary Care Physiotherapy Services CHO9, Health Service Executive (HSE), Dublin, Ireland; 5Curtin School of Allied Health, Curtin University, Perth, Australia; 6School of Allied Health, Ageing Research Centre, University of Limerick (UL), Limerick, Ireland; 7School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, Scotland; 8Later Life Training, Killin, UK; 9Department of Health Psychology, RCSI University of Medicine and Health Sciences, Dublin, Ireland; 10Healthcare Outcomes Research Centre (HORC), RCSI University of Medicine and Health Sciences, Dublin, Ireland; 11Older Person Services CHO9, Health Service Executive (HSE), Dublin, Ireland
Pro ﬁ le of Anders Björklund

W hen Anders Björklund started medical school in the early 1960s, scientists still believed that the structure of the adult brain was fixed and immutable and that nerve cells could not be regenerated after damage or death. But that view changed when Björklund began using a powerful new fluorescence microscopic method to view subsets of neurons. He became convinced that given the right conditions, immature neurons could be inserted into the brain to help regenerate damaged areas. That leap of faith—and the groundbreaking revelations that followed—jumpstarted his pioneering career in neuroscience. Björklund, a founder of the Wallenberg Neuroscience Center (Lund, Sweden) and recently elected member of the National Academy of Sciences, is currently a professor and head of the neurobiology unit at Lund University in Lund, Sweden. In 2011, he received the Robert A. Pritzker Prize for Leadership in Parkinson Research from the Michael J. Fox Foundation. His initial finding soon opened the door to an entirely new line of research. After revealing that dopamine neurons could be transplanted into rats to relieve Parkinsonlike symptoms, Björklund and former student Olle Lindvall initiated the first clinical trials in Parkinson patients to confirm that dopamine neuroblasts, implanted into the striatum, can survive, integrate, and function for years in the diseased brain. Researchers at Lund are now exploring the use of customized stem cells to treat Parkinson disease. The Inaugural Article by Lundblad et al. (1) delves deeper into understanding the causes of Parkinson in hopes of identifying effective alternative therapies for the disease.
Chronic Cough and Phlegm in Subjects Undergoing Comprehensive Health Examination in Japan – Survey of Chronic Obstructive Pulmonary Disease Patients Epidemiology in Japan (SCOPE-J)

Purpose: The purpose of this study was to estimate the prevalence of subjects with chronic cough and phlegm and describe their characteristics including the presence or absence of air ﬂ ow limitation among the general population in Japan. Subjects and Methods: This was an observational cross-sectional survey targeting multiple regions of Japan. Subjects aged 40 years or above who were undergoing comprehensive health examination were recruited. The existence of chronic cough and phlegm, air ﬂ ow limitation, and treatment for respiratory diseases were examined. Chronic cough and phlegm were de ﬁ ned as having both symptoms for at least 3 months of the year and for at least 2 consecutive years, or as receiving any treatment for chronic bronchitis at the time of recruitment. Air ﬂ ow limitation was de ﬁ ned as forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) less than 0.7. Results: In a total of 22,293 subjects, 380 subjects (1.7%) had chronic cough and phlegm. Among these 380 subjects, 21.8% received treatment for a respiratory disease, and 11.6% had air ﬂ ow limitation. Compared to subjects without both chronic cough and phlegm but with air ﬂ ow limitation, subjects with chronic cough and phlegm without air ﬂ ow limitation were younger, more likely to be current smokers (39.6%), and had higher total scores on a chronic obstructive pulmonary disease (COPD) assessment test (CAT). Scores of CAT questions 1 – 4 (cough, phlegm, chest tightness, breathlessness, respectively) were higher in subjects with chronic cough and phlegm regardless of air ﬂ ow limitation. Conclusion: This study demonstrated that subjects identi ﬁ ed to have chronic cough and phlegm in comprehensive health examination settings were symptomatic, while most of them did not receive any treatment for respiratory diseases and did not have air ﬂ ow limitation. Screening subjects for chronic cough and phlegm in a comprehensive health examination followed by a detailed examination of screened subjects could be an effective approach for better management of chronic cough and phlegm. Smoking cessation should be included in the management, in consideration that around 40% of subjects with chronic cough and phlegm were current smokers.
A global asymptotic stability condition for a dimorphic Lotka-Volterra model with explicit indirect interactions

A two-species Lotka-Volterra model extended with an arbitrary number of indirect interactions through 10 diﬀusible and renewable compounds is presented according to its relevance in microbial community modelling. After the determination of the system’s ﬁxed points and a short discussion over their local asymptotic stability, Lyapunov’s second method is applied to derive a suﬃcient condition of global asymptotic stability. Biologically, this condition indicates the necessity for one microbial type to show strong self-inhibition and the compounds to be fastly replaced.
Effects of ageing and Alzheimer disease on haemodynamic response function: a challenge for eventâ•’related fMRI

Functional magnetic resonance imaging (fMRI) can generate brain images that show neuronal activity due to sensory, cognitive or motor tasks. Haemodynamic response function (HRF) may be considered as a biomarker to discriminate the Alzheimer disease (AD) from healthy ageing. As blood-oxygenation-level-dependent fMRI signal is much weak and noisy, particularly for the elderly subjects, a robust method is necessary for HRF estimation to efficiently differentiate the AD. After applying minimum description length wavelet as an extra denoising step, deconvolution algorithm is here employed for HRF estimation, substituting the averaging method used in the previous works. The HRF amplitude peaks are compared for three groups HRF of young, non-demented and demented elderly groups for both vision and motor regions. Prior works often reported significant differences in the HRF peak amplitude between the young and the elderly. The authors’ experimentations show that the HRF peaks are not significantly different comparing the young adults with the elderly (either demented or non-demented). It is here demonstrated that the contradictory findings of the previous studies on the HRF peaks for the elderly compared with the young are originated from the noise contribution in fMRI data.
Integrative Physiology Sonic Hedgehog–Modified Human CD34 Cells Preserve Cardiac Function After Acute Myocardial Infarction

Methods and Results: When injected into the border zone of mice after acute myocardial infarction, Shhmodified CD34 cells (CD34) protected against ventricular dilation and cardiac functional declines associated with acute myocardial infarction. Treatment with CD34 also reduced infarct size and increased border zone capillary density compared with unmodified CD34 cells or cells transfected with the empty vector. CD34
Carers of People with Dementia

Carer stress is well documented, especiall y in those caring for individuals with dementia. A recommendation of all national dementia strategies is to provide excellent support and information to carers of people with dementia. NICE guidance suggests that a range of tailored interventions including psychological input, psychoeducation and training courses should be offered to reduce caregiver burden and stress, although good quality outcome based evidence is lacking. On the basis of a narrative review of the literature, we describe current individual and multi component carer support packages available and discuss their evidence base, reflecting on outcomes for carers. The best evidence for effecti veness is with multicomponent interventions. Introduction The impact of caring for a person with dementia is often described as burdensome (Acton and Kang, 2001) and caring for someone with dementia has also been shown to impact on physical health (Pinquart and Sorensen, 2003, Zhu et. al. 2015) as well as anxiety levels (Cooper et al, 2007) In addition to providing care for people with dementia, health and social care services provide support for carers of people with dementia to improve outcomes for both, and to reduce carer burden. Interventions to aid carers of people with dementia include general carer support, education, formal approaches to care and respite as well as multi component interventions (a combination of different types of interventions). But availability of these interventions varies
Rise of the exoskeletons: Latest news in built environment research and innovation

Men routinely handle heavy loads in construction, making it the second highest ranked sector for musculoskeletal disorders in the UK, behind agriculture, forestry and fishing, according to latest statistics from the Health and Safety Executive.1 1 “Work related musculoskeletal disorders statistics (WRMSDs) in Great Britain, 2018”, Health and Safety Executive, 31 October 2018. The idea of donning a robot suit to lighten the load has long been a futuristic dream, but two recent developments suggest the concept may be transitioning from the realm of imagination to reality. Also in this round-up, the UK government just pumped £72m into an effort to make construction more like manufacturing, the University of Bath believes plastic bottles can be used in concrete, and more.
The International Journal of Business and Management Research “IJBMR”

In today's rapidly changing business environment, organizations particularly in the service industry are concerned about competition, the quality of their products and services. The purpose of this study is to determine the effects of intrinsic motivation on employee performance. The specific objectives of the study were to examine the effects of employee recognition, opportunities for advancement and responsibility on employee performance. The study employed survey research design. Stratified sampling and simple random were used. Both descriptive and inferential statistics were used to analyze data. The results indicated that HO1. Employee recognition has no effect on employee performance (r=.780, P=.000), HO2. Opportunities for advancement has no effect on employee performance (r= .767, P=.001) and HO3. Employee responsibility has no effect on employee performance (r=.787, P=.000). It could be concluded that improving intrinsic motivation resulted in significantly improved performance at work. The management should identify major intrinsic motivation that enhances employee performance.
China’s Experience of Poverty Alleviation in Typical Rural Areas

2020 is the decisive victory year in our my country’s poverty alleviation and the poverty alleviation office of the State Council and the National Publicity and Education Center have proposed that a national poverty alleviation village experience survey should be needed. Having been entrusted by the General Research Group of China Agricultural University, Jiangtian village, Xiuning County, Anhui Province, conducted a survey of poverty alleviation experience. This article will introduce the basic situation of Jiangtian village and the causes of poverty through field visits to explore a series of work and results achieved in the village since the start of poverty alleviation in 2013, including three aspects of industry, culture, and spirit. At last, discussing several issues derived from the work of the village to dig out characteristic policy enlightenment. This article will focus on the ways and means of Jiangtian villages’ successful poverty alleviation, and try to summarize the replicable and popularizable models of poverty alleviation in China.
AFLUID April 47/4

Shigaev, Alexander, Carol Asher, Hedva Latter, Haim Garty, and Eitan Reuveny. Regulation of sgk by aldosterone and its effects on the epithelial Na1 channel. Am J Physiol Renal Physiol 278: F613–F619, 2000. —Aldosterone is the major corticosteroid regulating Na1 absorption in tight epithelia and acts primarily by activating the epithelial Na1 channel (ENaC) through unknown induced proteins. Recently, it has been reported that aldosterone induces the serumand glucocorticoid-dependent kinase sgk and that coexpressing ENaC with this kinase in Xenopus laevis oocytes increases the amiloride-sensitive Na1 current (Chen SY, Bhargava A, Mastroberardino L, Meijer OC, Wang J, Buse P, Firestone GL, Verrey F, and Pearce D. Proc Natl Acad Sci USA 96: 2514–2519, 1999). The present study was done to further characterize regulation of sgk by aldosterone in native mammalian epithelia and to examine its effect on ENaC. With both in vivo and in vitro protocols, an almost fivefold increase in the abundance of sgk mRNA has been demonstrated in rat kidney and colon but not in lung. Induction of sgk by aldosterone was detected in kidney cortex and medulla, whereas the papilla expressed a constitutively high level of the kinase. The increase in sgk mRNA was detected as early as 30 min after the hormonal application and was independent of de novo protein synthesis. The observed aldosterone dose-response relationships suggest that the response is mediated, at least in part, by occupancy of the mineralocorticoid receptor. Coexpressing sgk and ENaC in Xenopus oocytes evoked a fourfold increase in the amilorideblockable Na1 channel activity. A point mutation in the b-subunit known to impair regulation of the channel by Nedd4 (Y618A) had no significant effect on the response to sgk.
Telomere Length in Renal Cell Carcinoma: The Jekyll and Hyde Biomarker of Ageing of the Kidney

: Renal cell carcinoma (RCC) is a heterogeneous group of cancers where the clear cell (ccRCC) is the most common and the most lethal. The absence of accurate diagnostic and follow-up biomarkers along with the time-limited response to therapies may explain the lethality and shows the necessity of new sensitive and speci ﬁ c biomarkers. One of the most studied molecules are the telomeres: specialized ribonucleoprotein structures that keep the structural integrity of the genome. Among other features, telomere length (TL) has been widely studied in several tumor models regarding its biomarker potential, due to the easy detection and quanti ﬁ cation. The scope of this review was to analyze all the information about this parameter in RCC. There was some disparity in the results of the studies, since some pointed to an association between short TL and risk or poor outcome of RCC; others between long TL and RCC outcome and some did not ﬁ nd any association. We propose some epidemiological and biological explanations to these differences. The telomeres may play a dual role during RCC carcinogenesis in the early stages, short telomeres may increase RCC risk and in late carcinogenesis, long telomeres seem to be associated with tumor prognosis. However, the controversy of the results along with the lack of speci ﬁ city are some problems that need to be clari ﬁ ed for the usage of TL as a prognostic biomarker.
SOCIOECONOMIC BACKGROUND AND COGNITIVE FUNCTIONING IN FOURTH GRADE CHILDREN

Measures Intellectual functioning, impulsivity-reflectivity, paired-associate and dissemination learning were given to 16 males and 16 female fourth graders from disadvantaged backgrounds and from advantaged background). Socioeconomic status differences were found in intellectual functioning but rot irt impulsivityreflectivity learning. There was some suggestion of a relationship between impulsivity and dissemination learning. Hypotheses regarding the latter finding were
Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: Insights into the phagosomal environment JOURNAL OF EXPERIMENTAL MEDICINE

Little is known about the biochemical environment in phagosomes harboring an infectious agent. To assess the state of this organelle we captured the transcriptional responses of Mycobacterium tuberculosis (MTB) in macrophages from wild-type and nitric oxide (NO) synthase 2–deficient mice before and after immunologic activation. The intraphagosomal transcriptome was compared with the transcriptome of MTB in standard broth culture and during growth in diverse conditions designed to simulate features of the phagosomal environment. Genes expressed differentially as a consequence of intraphagosomal residence included an interferon – and NO-induced response that intensifies an iron-scavenging program, converts the microbe from aerobic to anaerobic respiration, and induces a dormancy regulon. Induction of genes involved in the activation and -oxidation of fatty acids indicated that fatty acids furnish carbon and energy. Induction of E -dependent, sodium dodecyl sulfate–regulated genes and genes involved in mycolic acid modification pointed to damage and repair of the cell envelope. Sentinel genes within the intraphagosomal transcriptome were induced similarly by MTB in the lungs of mice. The microbial transcriptome thus served as a bioprobe of the MTB phagosomal environment, showing it to be nitrosative, oxidative, functionally hypoxic, carbohydrate poor, and capable of perturbing the pathogen’s cell envelope.
Some applications of Wigner’s D-matrix to The addition formulas for the Spherical harmonics And to Wigner D-matrix for the SO(4) group

In this work we use the Analytic Hilbert space (Fock space) and Wigner's D-matrix and its generating function as starting point to determine the generating functions of spherical harmonics and the 3-j symbols of SU (2) . We find also the well known addition formula for the spherical harmonics. We find also another addition formula for the spherical harmonics. By applying the homomorphism of SO(4) group with the groups ) 2 ( ) 2 ( SU SU ⊗ and the generating functions of the 3-j symbols of SU(2) we obtain the generating functions of Wigner D-matrix for the SO(4) group. We calculate also particulars cases of Wigner D-matrix of SO (4). Finally, we find a new derivation of the Generating function for Legendre polynomials. It is important to emphasize that our method is elementary and it is very useful in teaching of angular momentum.
A Study of Self Esteem and Emotional Intelligence among Performers in Kingdom of Dreams Theater Delhi

On here A corelational study was carried out to find gender differences among male and female performers from different theaters in Delhi; on emotional intelligence and self esteem and also to study the two concepts among the performers. Total Sample of 40 (20 male and 20 female) performers age between 25-35 yrs and those belonging to various activities in the theater were selected. Statistics used were ‘t’ value and Pearson correlation to study the hypotheses that female performers will be higher on emotional intelligence than the male performers in the theater, male and female performers do not differ on measures of self esteem, higher the emotional intelligence, higher will be the self esteem among female performers. Higher the emotional intelligence, higher will be the self esteem among male performers and there is no significant correlation between emotional intelligence and self esteem. In the study The Schutte Self Report Emotional Intelligence Test (SSEIT) and Rosenberg’s Self Esteem Scale were used as tools. Two non significant ‘t’ value for emotional intelligence among male and female performers and for self esteem indicates that there is a very low positive correlation(r= .25) between self esteem and emotional intelligence among male and female performers, a very low negative correlation ( r=-.07) between high scorer female performers, a high positive correlation (r=.68) between average scorer, a low positive correlation (r = .34) between average scorer females, a low negative correlation (r= .24)between high scorer males, a high positive correlation(r=.96) between high scorer females and there are no gender differences on emotional intelligence and self esteem were
Models for 3d vascular image analysis

In image processing, models are used to improve robustness of algorithms by introducing a priori knowledge. Deformable models, frequently used in the field of medical images, are described by means of energy functionals with data attachment terms and regularising terms. The regularising terms express constraints relating to the expected shapes. The expected shape of a blood vessel segment in 3D images obtained by Magnetic Resonance Imaging or by helicoidal Computed Tomography is often implicitly described by a generalised cylinder model, i.e. an association of an axis (vessel centreline) and a surface (vessel boundary). In this context, the data attachment terms involve, for candidate points, a measure of the likelihood of being located on the centreline or on the boundary. Such a measure can use models reflecting low-level local photometrical properties of the brightness patterns. This presentation will give an overview of the recently used models and will be illustrated by the authors' contribution.
Mice from Lethal Histoplasma capsulatum Infection

Excessive production of interleukin-4 impairs clearance of the fungal pathogen Histoplasma capsulatum in mice lacking the chemokine receptor CCR2. An increase in the interleukin-4 level is associated with decreased recruitment of dendritic cells to lungs; therefore, we investigated the possibility that these cells influence interleukin-4 production. Adoptive transfer of wild-type or CCR2 / bone marrow-derived dendritic cells loaded with heat-killed yeast cells to infected CCR2 / mice suppressed interkeukin-4 transcription. Surprisingly, transfer of cells did not reduce the fungal burden despite the fact that it limited interleukin-4 transcription. Yeast cell-loaded bone marrow-derived dendritic cell-mediated regulation of interleukin-4 transcription was dependent on major histocompatibility complex II antigen presentation to CD4 T cells. We previously showed that CD4 T cells were a source of interleukin-4 in infected CCR2 / mice, but their contribution to the TH2 phenotype was unclear. Here we demonstrated that these cells were functionally important since elimination of them prior to infection, but not elimination of them at the time of infection, reduced the interleukin-4 level in infected CCR2 / mice. However, the fungal burden was reduced only in CD4-depleted CCR2 / mice that received yeast cell-loaded bone marrow-derived dendritic cells. Taken together, the data indicate that generation of excess interleukin-4 in lungs of H. capsulatum-infected CCR2 / mice is at least partially a consequence of decreased recruitment of dendritic cells capable of antigen presentation. Furthermore, CD4 T cells had a deleterious impact on immunity in infected CCR2 / mice.
On machine learning methods for Chinese document classification

This paper reports our comparative evaluation of three machine learning methods, namely k Nearest Neighbor (kNN), Support Vector Machines (SVM), and Adaptive Resonance Associative Map (ARAM) for Chinese document categorization. Based on two Chinese corpora, a series of controlled experiments evaluated their learning capabilities and efficiency in mining text classification knowledge. Benchmark experiments showed that their predictive performance were roughly comparable, especially on clean and well organized data sets. While kNN and ARAM yield better performances than SVM on small and clean data sets, SVM and ARAM significantly outperformed kNN on noisy data. Comparing efficiency, kNN was notably more costly in terms of time and memory than the other two methods. SVM is highly efficient in learning from well organized samples of moderate size, although on relatively large and noisy data the efficiency of SVM and ARAM are comparable.