Miracle-dz/UniFAR-FTUs huggingface dataset:
Deprivation, Violence, and Conflict: An Analysis of Naxalite Activity in the Districts of India

This paper asks: is it a fact that there is more violence in districts affected by Naxalite (Maoist) activity compared to those which are free of Naxalite activity? And can the existence of Naxalite activity in some districts of India, but not in others, be explained by differences in economic and social conditions? This study identifies districts in India in which there was significant Naxalite activity and correlating the findings with district-level economic, social, and crime indicators. The econometric results show that, after controlling for other variables, Naxalite activity in a district had, if anything, a dampening effect on its level of violent crime and crimes against women. Furthermore, even after controlling for other variables, the probability of a district being Naxalite-affected rose with an increase in its poverty rate and fell with a rise in its literacy rate. So, one prong in an anti-Naxalite strategy would be to address the twin issues of poverty and illiteracy in India.
Human Miscarriage Is Associated With Dysregulations in Peripheral Blood-Derived Myeloid Dendritic Cell Subsets

Dendritic cells (DC) are critically involved in decisions related to the acceptance or rejection of the foreign fetal antigens by the maternal immune system. However, particularly for human peripheral blood DCs (PBDC), available literature is rather inconsistent and the factors regulating these cells are ill-defined. Here, we investigated the phenotype and functionality of different human PBDC subsets during normal and pathologic pregnancies and studied an involvement of human chorionic gonadotropin (hCG) in PBDC regulation. Peripheral blood samples were obtained from normal pregnant women in all three trimesters, from first trimester miscarriage patients and from healthy non-pregnant women. Samples were analyzed for plasma hCG levels, for regulatory T (Treg) cell numbers, for frequencies of total and mature plasmacytoid (PDC) and myeloid (MDC1 and MDC2) PBDC subsets and for their cytokine secretion. In vitro assays, culturing PDC, MDC1 or MDC2 in the presence of two trophoblast cell lines, placenta explant supernatants or two hCG preparations were performed. The Treg-inducing capability of hCG- or non-hCG-treated stimulated MDC1 was assessed. Total and mature MDC1 and MDC2 frequencies increased during the first and second trimester of normal pregnancy, respectively. Miscarriage was associated with a reduced MDC1 and an increased MDC2 activation profile. PDC were not altered neither during normal pregnancy progression nor during miscarriage. In vitro, the culture of isolated PBDC subsets in the presence of placenta-derived factors impaired the maturation of MDC1 and differentially affected PDC maturation. An inhibitory effect on MDC1 and PDC maturation was also proven for the urine-derived hCG preparation. Finally, we observed a Treg cell elevation during early normal pregnancy that was not present in miscarriages. Stimulated MDC1 induced Treg cells in vitro, however, hCG was not involved in this process. Our findings suggest that during normal pregnancy PBDC subsets are differentially regulated dependent on gestational age. Miscarriage seems to be associated with dysregulations in the myeloid PBDC subsets and with disturbances in Treg cell frequencies. Moreover, our results propose an interdependency between MDC1 and Treg cells during early pregnancy. hCG, although shown to impair MDC1 maturation, does not seem to be a key regulator of PBDC alterations during pregnancy.
Constructing politicized national identities: identity positioning by US, China, and Philippine opinion editorials on the Scarborough Shoal conflict

ABSTRACT How do newspapers’ opinion editorials produce national identities of nations involved in an international conflict? This study examines op-eds in the US, China and the Philippines, which discuss the Scarborough Shoal conflict. Data processing includes word-association calculations and positioning analysis. Results demonstrate self-vested national identities. China-based articles create national identities around the goal of preserving political clout in the Asia-Pacific. US op-eds invert China’s goal and generate identities asserting US regional power. Philippine commentaries portray China as a bully and the US as a defender. Results are discussed in light of the link between politicized national identities and global clashes.
Original Article The Epidemiology of Breast Cancer in Taiwan

According to the statistics of Department of Health in Taiwan, the incidence of breast cancer had increased 4 fold in the past twenty years. Since 2003, the incidence of breast cancer had exceeded cervical cancer and became the most common female cancer in Taiwan, and the fourth cause of female cancer death. The incidence of female breast cancer was 12.7 per 100,000 women in 1980, and then increased gradually. It was 16.41 per 100,000 women in 1985, 28.68 per 100,000 women in 1995 and 49 per 100,000 women in 2005. In Taiwanese women, the increase in breast cancer incidence with increasing age was slower in earlier cohorts of early birth cohort, and the increase became faster in the later birth cohort. For Caucasian women, the increase in breast cancer incidence with increasing age seemed similar between earlier and later cohorts. Urban area had higher incidence than the rural area and northern part of Taiwan had the highest incidence. Although mammographic screening had been widely practiced in Western countries, there is only limited experience in Asian area. Breast cancer screening has evolved from 1995 to 2004 in Taiwan in three stages: (1) selective screening for breast cancer with mammography, ultrasound and physical examination only in first-degree relatives of breast cancer cases (1995-1998); (2) a programme of mass screening (1999-2001) with physical examination by public health nurses; and (3) two-stage breast cancer screening with a risk factor questionnaire and mammography for those deemed at moderate-to-high risk (2002-2004). The positive predictive value was 2% for physical examination and 8% for selective screening. Two-stage mammography screening had the most favorable results compared with the two previous screening regimens. It had 14% positive predictive value. For a low- to medium-risk country such as Taiwan, two-stage screening has acceptable parameters of recall and cancer detection, and compares well with other screening strategies. Currently there is a pilot study of breast cancer screening by sonography in 40-49 year-old women in Taiwan and we could obtain the result in near future. Breast cancer is a major threat of woman health in Taiwan. We need to learn more for early detection of breast cancer, and improve the health of women in Taiwan.
Spike protein binding prediction with neutralizing antibodies of SARS-CoV-2

Coronavirus disease 2019 (COVID-19) is a new emerging human infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, also previously known as 2019-nCoV), originated in Wuhan seafood and animal market, China. Since December 2019, more than 69,000 cases of COVID-19 have been confirmed in China and quickly spreads to other counties. Currently, researchers put their best efforts to identify effective drugs for COVID-19. The neutralizing antibody, which binds to viral capsid in a manner that inhibits cellular entry of virus and uncoating of the genome, is the specific defense against viral invaders. In this study, we investigate to identify neutralizing antibodies that can bind to SARS-CoV-2 Sipke (S) protein and interfere with the interaction between viral S protein and a host receptor by bioinformatic methods. The sequence analysis of S protein showed two major differences in the RBD region of the SARS-CoV-2 S protein compared to SARS-CoV and SARS-CoV related bat viruses (btSARS-CoV). The insertion regions were close to interacting residues with the human ACE2 receptor. Epitope analysis of neutralizing antibodies revealed that SARS-CoV neutralizing antibodies used conformational epitopes, whereas MERS-CoV neutralizing antibodies used a common linear epitope region, which contributes to form the β-sheet structure in MERS-CoV S protein and deleted in SARS-CoV-2 S protein. To identify effective neutralizing antibodies for SARS-CoV-2, the binding affinities of neutralizing antibodies with SARS-CoV-2 S protein were predicted and compared by antibody-antigen docking simulation. The result showed that CR3022 neutralizing antibody from human may have higher binding affinity with SARS-CoV-2 S protein than SARS-CoV S protein. We also found that F26G19 and D12 mouse antibodies could bind to SARS-CoV S protein with high affinity. Our findings provide crucial clues towards the development of antigen diagnosis, therapeutic antibody, and the vaccine against SARS-CoV-2.
Thromboprophylaxis after bariatric surgery

Background Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is a known cause of morbidity and mortality after bariatric surgery. However, the data concerning appropriate thromboprophylaxis after bariatric surgery is uncertain. The objective of this study was to evaluate the efficacy and safety of extended duration thromboprophylaxis in post-bariatric surgery patients. Methods We conducted a retrospective study of consecutive patients who underwent bariatric surgery from November 2014 to October 2018 at King Fahad General Hospital in Jeddah, Saudi Arabia. All included patients were treated with extended duration thromboprophylaxis. Results We identified 374 patients who underwent bariatric surgery during the study period. Of these, 312 patients (83%) were followed for at least 3 months. The most common type of surgery was a laparoscopic sleeve gastrectomy (N=357) and the median weight was 110 kg. The cumulative incidence of symptomatic postoperative VTE at 3 months was 0.64% (95% confidence interval, 0.20–1.52). All events occurred after hospital discharge. The most commonly used pharmacological prophylaxis (91%) for VTE prevention after bariatric surgery was enoxaparin 40 mg subcutaneously twice daily for 10–14 days after hospital discharge. There were no reported cases of bleeding or VTE related mortality after 3 months. Conclusion Extended thromboprophylaxis after bariatric surgery appears to be an effective and safe strategy for VTE prevention. Large prospective studies are needed to evaluate the optimal thromboprophylaxis regimen after bariatric surgery.
Probing User Perceptions of On-Skin Notification Displays

On-skin displays are emerging as a wearable form factor for the display of information; however, the perception of using such devices in public could determine whether they are eventually adopted or rejected. This study investigated the means by which on-skin notification displays are perceived by the general public. We adopted a mixed-methods approach to the analysis of results from an online survey (n = 254) and in-lab interviews (n = 36) pertaining to the novel form factor, device materiality, and envisioned use cases. The study was conducted in the US and Taiwan in order to examine cross-cultural attitudes toward device usage. The results of this structured examination provide valuable insights into the design of on-skin notification displays for everyday use across cultures.
Multi-attribute taxi logistics optimization

According to U.S. government surveys, 12% of Americans used taxi service in the previous month' and spent about $3.7 billion a year for cab fare.2 Taxi service is one of the major modes of public transportation. Despite providing services 24 hours a day, driving relentlessly with an empty taxicab in search of passengers and answering dispatch calls instantaneously, taxi service is ranked the most unsatisfactory mode of transportation by the public. Charging higher fares than other major modes of transportation and averaging 10 to 12 hours work day, taxi drivers have a difficult time to earn a sustainable income. Approximately half of all the taxi mileage is paid mileage; this means a significant portion of a taxi's time and fuel is spent on non-revenue generating activities, i.e. without passengers. Current taxi allocation is inefficient. The number of taxis and the geographical service areas which they serve are heavily regulated in most cities. With limited competition and strict regulations, taxi service suffers with customers having to endure long wait times and inferior services. The current taxi systems in most U.S. cities may be greatly improved from their current state. This thesis investigates the factors of inefficiency in the current taxi system, reviews previous taxi efficiency studies, and suggests possible solutions. After extensive literature reviews and field research, a computer simulation model has been built in the MATLAB environment. This computer model tests various attributes that affect logistic optimizations for taxi services. In particular, the effect of taxi fleet size, the quantity of hotspots, and the concentrations of customers at hotspots are analyzed in detail using the ' Bureau of Transportation Statistics. October, 2003. http://www.bts. gov/programs/oinnibus surveys/household survey/2003/october/ 2 Schechner, S. , Cranky Consumer: Hiring a Taxi During Rush Hour, The Wall Street Journal, April 26, 2005.
A study on major factors revitalizing nursing staff's work enthusiasm ∼ a cross-national study on organizational culture, organizational empowerment and self-efficacy

ABSTRACT This study, taking statistic test approach, was conducted to explore the manifest components, focusing on organizational culture, organizational empowerment, and self-efficacy, which have been approved as crucial factors vitalizing nursing staff' career enthusiasm. We adopted a cross-sectional research design, and used the organizational culture, organizational empowerment and self-efficacy scales as the research instruments. From August 10 to September 25, 2021, the head nurses collected data using questionnaires. Selected participants were the nursing staff in hospitals from Taiwan, Indonesia and Vietnam, with a total of 302 valid questionnaires were collected. Descriptive statistical analysis, independent sample t-test, analysis of variance test, Pearson correlation analysis, regression analysis was carried out. Taiwan's organizational culture score is the highest, followed by Vietnam and Indonesia; In terms of organizational empowerment, Indonesia has the highest score, followed by Taiwan and Vietnam; In terms of self-efficacy, Vietnam has the highest score, followed by Taiwan and Indonesia. Organizational empowerment indirectly affects self-efficacy through organizational culture. Organizational culture plays an important role in organizational empowerment that affects self-efficacy. It is recommended that qualitative and in-depth research and face-to-face in-depth interviews will be helpful for the depth and connotation of the research data.
NDT_A_209806 2129..2136

Chih-Yu Huang Chung-Chieh Yu 1Division of Pulmonary, Critical Care, and Sleep Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan, Republic of China; 2College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China Objective: Periodic leg movement in sleep (PLMS) is common among patients with obstructive sleep apnea (OSA). The PLMS frequency changes after continuous positive airway pressure (CPAP) titration. This study investigated the effects of two PLMS diagnostic criteria on PLMS prevalence and the restless leg syndrome (RLS) detection rate in patients with OSA before and after CPAP titration. Methods: This retrospective study included patients with OSA who received polysomnography (PSG) and successful CPAP titration from December 2012 to December 2014. Their clinical variables and sleep parameters were evaluated using the PLMS diagnostic criteria: PLMS index (PLMI) ≥5 and ≥15. PLMS prevalence and the RLS detection rate were analyzed according to the PLMI before and after CPAP. Results: In patients with OSA with a PLMI of ≥5 and ≥15 after PSG with CPAP titration, the PLMS prevalence was 20.1% (76/378) and 4.5% (17/378), respectively, which revealed CPAP titration increased PLMI. Moreover, in terms of PLMI ≥5 and ≥15, PSG with CPAP titration led to significantly higher PLMS prevalence than PSG alone (20.1% vs 7.1% and 4.5% vs 0.8%, respectively; both P<0.001). PLMI ≥5 also demonstrated a higher RLS detection rate than PLMI ≥15 did (69.2% vs 15.4%; P=0.016). Conclusion: In patients with OSA, CPAP titration increases PLMS prevalence and the PLMI regardless of whether PLMI is ≥5 or ≥15. The use of the current diagnostic criteria, PLMI ≥15, for PLMS may lead to underestimation of PLMS prevalence and the RLS detection rate in patients with OSA.
Artificial intelligence for rapid identification of the coronavirus disease 2019 (COVID-19)

The coronavirus disease 2019 (COVID-19) outbreak that originated in Wuhan, China has rapidly propagated due to widespread person-to-person transmission and has resulted in over 1,133,758 cases in 197 countries with a total of 62,784 deaths as of April 5, 2020. Laboratory confirmation of SARS-CoV-2 is performed with a virus-specific reverse transcriptase polymerase chain reaction (RT-PCR) test. This test can take up to two days to complete, and, due to the possibility of false negatives, serial testing may be required to reliably exclude infection. A current supply shortage of RT-PCR test kits compounds the shortcomings of entrusting diagnosis to the PCR test alone and underscores the urgent need to provide alternative methods for the rapid and accurate diagnosis of SARS-CoV-2 patients. Chest computed tomography (CT) is a valuable component in the evaluation of patients with suspected SARS-CoV-2 infection. Nevertheless, CT alone may have limited negative predictive value to fully exclude infection, because of the normal radiologic findings in some early disease patients. In this study, we use artificial intelligence (AI) algorithms to integrate chest CT findings with clinical symptoms, exposure history, and/or laboratory testing to more accurately and rapidly diagnose SARS-CoV-2 (+) patients. We included 905 RT-PCR confirmed patients. 419 (46.2%) tested positive for SARS-CoV-2 by laboratory-confirmed real-time RT-PCR assay and next-generation sequencing, while 486 patients (53.8%) tested negative (confirmed by at least two additional negative RT-PCR tests and clinical observation). The proposed AI system achieved an AUC of 0.92 and performed equally well in sensitivity compared to a senior thoracic radiologist on a testing set of 279 cases. The AI system also improved the detection of RT-PCR positive SARS-CoV-2 patients who presented with normal CTs, correctly identifying 17/25 (68%) patients, whereas all 25 RT-PCR SARS-CoV-2-positive CT-normal patients were classified as SARS-CoV-2 negative by radiologists.
Drier North American monsoon in contrast to Asian-African 1 monsoon under global warming 2 3

3 Chao He, Tim Li, Wen Zhou 4 5 1. Institute for Environmental and Climate Research, Jinan University, Guangzhou, China 6 2. Guy Carpenter Asia-Pacific Climate Impact Centre, School of Energy and 7 Environment, City University of Hong Kong, Hong Kong, China 8 3. International Pacific Research Center and Department of Atmospheric Sciences, 9 University of Hawaii, Honolulu, USA 10 11 Revised to Journal of Climate 12 13
Chemistry and Biological Activity of Alkaloids from the Genus Lycoris (Amaryllidaceae)

Lycoris Herbert, family Amaryllidaceae, is a small genus of about 20 species that are native to the warm temperate woodlands of eastern Asia, as in China, Korea, Japan, Taiwan, and the Himalayas. For many years, species of Lycoris have been subjected to extensive phytochemical and pharmacological investigations, resulting in either the isolation or identification of more than 110 Amaryllidaceae alkaloids belonging to different structural types. Amaryllidaceae alkaloids are frequently studied for their interesting biological properties, including antiviral, antibacterial, antitumor, antifungal, antimalarial, analgesic, cytotoxic, and cholinesterase inhibition activities. The present review aims to summarize comprehensively the research that has been reported on the phytochemistry and pharmacology of the genus Lycoris.
The Psychological Pressures of Breast Cancer Patients During the COVID-19 Outbreak in China—A Comparison With Frontline Female Nurses

Objective: During the outbreak of the COVID-19 epidemic in China, breast cancer (BC) patients and healthcare workers faced several challenges, resulting in great psychological stress. We measured the psychological status of BC patients and female nurses and compared the severity within the two groups at the peak time-point of the COVID-19 outbreak. Methods: A total of 207 BC patients and 684 female nurses were recruited from Wuhan. They completed an anonymous questionnaire online using the most popular social media software in China, WeChat. The psychological status of BC patients and of female nurses was measured using the Chinese versions of the 9-item Patient Health Questionnaire (PHQ-9), the 7-item Generalized Anxiety Disorder scale (GAD-7), the 7-item Insomnia Severity Index (ISI), and the 22-item Impact of Event Scale-Revised (IES-R) for evaluation of post-traumatic stress disorder (PTSD). The differences between the two groups were analyzed. Results: The scores of BC patients and frontline female nurses for the four scales were significantly higher than those of non-frontline female nurses (P < 0.001). There were similar scores between BC patients and frontline female nurses for PHQ-9, GAD-7, and IES-R (P = 0.789, P = 0.101, P = 0.158, respectively). Notably, the scores of BC patients for ISI were significantly higher than those of the frontline female nurses (P = 0.016). A considerable proportion of BC patients reported symptoms of depression (106/207, 51.2%), anxiety (130/207, 62.8%), insomnia (106/207, 51.2%), and PTSD (73/207, 35.5%), which was more severe than that of female nurses. Conclusions: BC patients experienced great psychological pressure during the COVID-19 outbreak. The incidents of symptomatic anxiety, depression, sleep disorders, and PTSD were significantly comparable to that of frontline female nurses, and episodes of insomnia among BC participants were more serious than for frontline female nurses.
Genomic Evidence of an Ancient East Asian Divergence Event in Wild Saccharomyces cerevisiae

Abstract Comparative genome analyses have suggested East Asia to be the cradle of the domesticated microbe Brewer’s yeast (Saccharomyces cerevisiae), used in the food and biotechnology industry worldwide. Here, we provide seven new, high-quality long-read genomes of nondomesticated yeast strains isolated from primeval forests and other natural environments in China and Taiwan. In a comprehensive analysis of our new genome assemblies, along with other long-read Saccharomycetes genomes available, we show that the newly sequenced East Asian strains are among the closest living relatives of the ancestors of the global diversity of Brewer’s yeast, confirming predictions made from short-read genomic data. Three of these strains (termed the East Asian Clade IX Complex here) share a recent ancestry and evolutionary history suggesting an early divergence from other S. cerevisiae strains before the larger radiation of the species, and prior to its domestication. Our genomic analyses reveal that the wild East Asian strains contain elevated levels of structural variations. The new genomic resources provided here contribute to our understanding of the natural diversity of S. cerevisiae, expand the intraspecific genetic variation found in this heavily domesticated microbe, and provide a foundation for understanding its origin and global colonization history.