Miracle-dz/UniFAR-FTUs huggingface dataset:
Atlantic Zonal Mode-Monsoon Teleconnection in a Warming Scenario

The dominant interannual SST variability in the eastern equatorial 7 Atlantic referred to as the Atlantic Zonal Mode (AZM), which peaks in boreal 8 summer impacts global weather patterns. The cold (warm) phase of this ocean- 9 atmospheric coupled phenomenon enhances (weakens) the intensity of the Indian 10 summer monsoon rainfall (ISMR). Observational studies show a strengthening 11 relationship between AZM and ISMR in recent decades, providing a predictive 12 signal for the ISMR. However, a suite of Coupled Model Intercomparison Project 13 Phase 6 (CMIP6) model simulations in the highest emission scenario (SSP58.5) 14 show a weakening relationship between ISMR and AZM in the future (2050-2099). 15 The strengthening of atmospheric thermal stability over the tropical Atlantic in the 16 warming scenario weakens the associated convection over the eastern equatorial 17 Atlantic in response to the warm phase of AZM. This leads to weakening velocity 18 potential response over the Indian subcontinent, resulting in a weak AZM-ISMR 19 relationship. There is no convincing evidence to indicate that either the tropical 20 Atlantic SST bias or the AZM-ISMR teleconnection bias plays a crucial role in the 21 potential weakening of this relationship. These results imply that ISMR prediction 22 will become more challenging in a warming scenario as one of the major external 23 boundary forces that inﬂuence monsoon weakens. 24 seasonal mean rainfall is carried out. The multimodel mean of 12 ’good’ models shows neg- ative correlation values over central India and western Ghats as in observations
Prevalência e variáveis associadas à inatividade física em indivíduos de alto e baixo nível socioeconômico

BACKGROUND: Studies that considered only the leisure physical activity found that the physical inactivity is higher among lower-income individuals. There is a possibility that this association shows modifications, when considering transportation, work and domestic activities. OBJECTIVE: To determine whether there is a difference between the prevalence of physical inactivity between individuals of high and low socioeconomic levels. METHODS: The sample consisted of individuals of both sexes, aged 18 or older, from two groups of different socioeconomic levels. The low socioeconomic level (LSEL) group consisted of the parents of students from a public school. The high socioeconomic level (HSEL) group consisted of the parents of students from a private College. The International Physical Activity Questionnaire (IPAQ) was used to determine the level of physical activity. RESULTS: A total of 91 individuals were evaluated in the LSEL group and 59 in the HSEL group. In the LSEL group, 42.9% (39) of the individuals were classified as insufficiently active, compared to 57.6% (34) of individuals in the HSEL group. Taking as a parameter of physical inactivity the time of weekly physical activity < 150 minutes, there was a decrease in the classification of inactivity in both groups, although with the maintenance of higher inactivity among individuals of HSEL (49.2% vs 28.6%; p= 0.01). CONCLUSION: The individuals of HSEL are more sedentary than the individuals of LSEL.
Stem cell harvesting after bortezomib-based re-induction for myeloma relapsing after autologous transplant: results from the BSBMT/UKMF Myeloma X (Intensive) trial

Please cite this article as: Parrish C, Morris CT, Williams CD, Cairns DA, Cavenagh J, Snowden JA, Ashcroft J, Cavet J, Hunter H, Bird JM, Chalmers A, Brown JM, Yong K, Schey S, Chown S, Cook G, on behalf of the National Cancer Research Institute Haemato-Oncology Clinical Studies Group, Stem cell harvesting after bortezomib-based re-induction for myeloma relapsing after autologous transplant: results from the BSBMT/UKMF Myeloma X (Intensive) trial, Biology of Blood and Marrow Transplantation (2016), doi: 10.1016/j.bbmt. 2016.01. 016.
Plasma Amino Acid Appearance and Status of Appetite Following a Single Meal of Red Meat or a Plant-Based Meat Analog: A Randomized Crossover Clinical Trial

ABSTRACT Background Red meat is a nutrient-dense food and a dietary staple. A new generation of plant-based meat analogs (PBMAs) have been designed to mimic the experience of eating meat, but there is limited evidence about their digestive efficacy and nutritional quality. Objectives We compared the postprandial digestive response of a single meal containing meat commercially raised in New Zealand, including lamb, on-farm pasture-raised beef (Pasture), or grain-finished beef (Grain) with a PBMA (Beyond Burger; Beyond Meat) sold through consumer retail. The primary outcome was the appearance of amino acids in plasma. Secondary outcomes included glucose and insulin, appetite assessment, and anthropometry. Methods Thirty healthy men (20–34 y) participated in a double-blinded randomized crossover trial. Each consumed 1 of the 4 test meals on 4 occasions separated by a washout period of at least 1 wk, following an overnight fast. The meal was a burrito-style wrap containing meat or PBMAs, vegetables, salsa, and seasonings in a flour tortilla. The amount of Pasture, Grain, Lamb, or BB was 220 g raw (∼160 g cooked). Venous blood samples were collected over 4 h. Appetite and hunger status was scored with visual analog scales. Results Pre-meal amino acid concentrations in plasma did not differ by group (P > 0.9), although several nonessential amino acids differed strongly according to participant BMI. Postprandial amino acids peaked at 2–3 h in all groups. The BB meal produced significantly lower plasma concentrations of total, essential, branched-chain, and non-proteogenic amino acids than the Lamb, Pasture, or Grain meals, based on AUC. There were no significant differences between meal groups in scores for hunger, fullness, or cravings. Conclusions Red meat meals exhibited greater bioavailability of amino acids compared with the PBMA (BB). Pasture versus Grain origins of the beef had little influence on participants’ responses. This trial was registered at ClinicalTrials.gov as NCT04545398.
Reply to M Mindrum and J Moore et al

C © The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Published online May 27, 2022.
Risk factors for disease severity and increased medical resource utilization in respiratory syncytial virus (+) hospitalized children: A descriptive study conducted in four Belgian hospitals

Background We aimed to provide regional data on clinical symptoms, medical resource utilization (MRU), and risk factors for increased MRU in hospitalized respiratory syncytial virus (RSV)-infected Belgian pediatric population. Methods This prospective, multicenter study enrolled RSV (+) hospitalized children (aged ≤5y) during the 2013–2015 RSV seasons. RSV was diagnosed within 24h of hospitalization. Disease severity of RSV (+) patients was assessed until discharge or up to maximum six days using a Physical Examination Score (PES) and a derived score based on ability to feed, dyspnea and respiratory effort (PES3). MRU (concomitant medications, length of hospitalization [LOH], and oxygen supplementation) was evaluated. Kaplan-Meier survival analysis was performed to compare MRU by age and presence of risk factors for severe disease. Association between baseline covariates and MRU was analyzed using Cox regression models. Results In total, 75 children were included, Median (range) age was 4 (0–41) months, risk factors were present in 18.7%, and early hospitalization (≤3 days of symptom onset) was observed in 57.3% of patients. Cough (100%), feeding problems (82.2%), nasal discharge (87.8%), and rales and rhonchi (82.2%) were frequently observed. Median (range) LOH and oxygen supplementation was 5 (2–7) and 3 (1–7) days. Oxygen supplementation, bronchodilators, and antibiotics were administered to 58.7%, 64.0%, and 41.3% of the patients, respectively. Age <3 months and baseline total PES3 score were associated with probability and the duration of receiving oxygen supplementation. LOH was not associated with any covariate. Conclusion RSV is associated with high disease burden and MRU in hospitalized children. Oxygen supplementation but not length of hospitalization was associated with very young age and the PES3 score. These results warrant further assessment of the PES3 score as a predictor for the probability of receiving and length of oxygen supplementation in RSV hospitalized children. Registration NCT02133092
An analysis of the success of fiscal adjustment in reducing public debt: Evidence from Pakistan

This study seeks answers to questions such as: what is fiscal adjustment? Which fiscal strategy will result in a reduction in public debt liabilities? In the pursuit of answers to these questions, the study has defined two objectives. Firstly, the fiscal adjustment episodes must be identified in order to detach the discretionary fiscal stance; secondly, the success of these adjustment episodes in reducing public debt liabilities must be assessed. As a result, attempts will be made to undertake analyses that would simplify the issues underlying Pakistan’s practical policy options. A total of eleven adjustment episodes have been observed in a sample, ranging from 1976 to 2017, following Alesina and Ardagna’s definition. The descriptive analysis reveals that five episodes succeeded in reducing the public debt, while six episodes failed to reduce the ratio. Out of the five successful episodes, four are found to be spending-based and one is tax-based. To quantify the success of fiscal adjustment, the empirical model has been calibrated on Leibrecht and Scharler’s model and estimation is done via both the Ordinary Least Squares (OLS) and Robust Least Squares (RLS) methods. The RLS method produces better outcomes than the OLS method. Under RLS, all variables are significant except GDP growth, whereas in the OLS model, the election year and regime shift, together with GDP growth, are statistically insignificant. The fiscal adjustment’s composition reveals that spending-based consolidation boosts the chances of the fiscal adjustment’s success. Fiscal authorities should, therefore, adopt spending-based austerity measures to ensure the sustainability of public finances and prevent the negative macroeconomic consequences of unsustainable public debt.
Changes in dynamics of tumor/endothelial cell adhesive interactions depending on endothelial cell growth state and elastic properties

Cancer cell adhesion to the endothelium is a crucial process in hematogenous metastasis, but how the integrity of the endothelial barrier and endothelial cell (EC) mechanical properties influence the adhesion between metastatic cancer cells and the endothelium remain unclear. In the present study, we have measured the adhesion between single cancer cells and two types of ECs at various growth states and their mechanical properties (elasticity) using atomic force microscopy single cell force spectroscopy. We demonstrated that the EC stiffness increased and adhesion with cancer cells decreased, as ECs grew from a single cell to a confluent state and developed cell-cell contacts, but this was reversed when confluent cells returned to a single state in a scratch assay. Our results suggest that the integrity of the endothelial barrier is an important factor in reducing the ability of the metastatic tumor cells to adhere to the vascular endothelium, extravasate and lodge in the vasculature of a distant organ where secondary metastatic tumors would develop.
FINITE DIMENSIONAL APPROXIMATIONS TO WIENER MEASURE AND PATH INTEGRAL FORMULAS ON MANIFOLDS

Abstract Certain natural geometric approximation schemes are developed for Wiener measure on a compact Riemannian manifold. These approximations closely mimic the informal path integral formulas used in the physics literature for representing the heat semi-group on Riemannian manifolds. The path space is approximated by finite dimensional manifolds H P ( M ) consisting of piecewise geodesic paths adapted to partitions P of [0, 1]. The finite dimensional manifolds H P ( M ) carry both an H 1 and a L 2 type Riemannian structures, G 1 P and G 0 P , respectively. It is proved that (1/ Z i P ) e −(1/2) E ( σ ) d Vol G i P ( σ )→ ρ i ( σ ) dν ( σ ) as mesh ( P )→0, where E ( σ ) is the energy of the piecewise geodesic path σ ∈ H P ( M ), and for i =0 and 1, Z i P is a “normalization” constant, Vol G i P is the Riemannian volume form relative to G i P , and ν is Wiener measure on paths on M . Here ρ 1 ( σ )≡1 and ρ 0 ( σ )=exp(− 1 6 ∫ 1 0 Scal( σ ( s )) ds ) where Scal is the scalar curvature of M . These results are also shown to imply the well known integration by parts formula for the Wiener measure.
Applications of multispectral and hyperspectral imaging in dermatology

Vision is essential in the diagnostic capabilities in the speciality of dermatology. However, humans are limited in colour vision by the trichromatic visual system that we possess. Multispectral and hyperspectral imaging can overcome this limitation and non‐invasively provide novel information about a skin lesion at the cellular level. A literature review from January 2019 to March 2021 for hyperspectral and multispectral imaging in the field of dermatology was conducted. Multispectral/Hyperspectral imaging continues to generate significant research and interest in dermatology. Much of this research is on distinguishing melanoma from benign nevi as this could allow for a diagnosis without biopsy. In addition, adding multispectral/hyperspectral imaging to smartphones is being researched in order to create a portable and low‐cost device that can be used in remote areas. One of the limitations in developing devices utilizing hyperspectral imaging has been a sacrifice in specificity in order to maximize sensitivity. Potential solutions to combat this that are being researched include combining multispectral/hyperspectral imaging with other imaging modalities such as photoacoustic imaging in order to overcome the limitations of using each individually. Multispectral/Hyperspectral imaging could be an instrumental aid for clinicians in examining, diagnosing and developing the management plan for patient's skin lesions.
Leptomeningeal metastases in patients with human epidermal growth factor receptor 2 positive breast cancer: Real‐world data from a multicentric European cohort

In patients with human epidermal growth factor receptor 2 positive (HER2+) breast cancer, leptomeningeal metastases (LM) are a rare but often a fatal clinical scenario. In this multicentric study, clinical and pathologic characteristics of patients with HER2+ breast cancer developing LM were described, as well as survival outcomes. Data were gathered retrospectively from medical records of 82 patients with advanced HER2+ breast cancer and LM treated between August 2005 and July 2020. Following LM diagnosis, 79 (96.3%) patients received at least one line of anti‐HER2 therapy, 25 (30.5%) patients received intrathecal therapy and 58 (70.7%) patients received radiotherapy. Overall survival (OS) was 8.3 months (95% confidence interval [CI] 5.7‐11), 1‐year OS was 42%, and 2‐year OS was 21%. At univariate analysis, patients who were treated after 2010, had better Karnofsky performance status, were free of neurological symptoms, had better prognostic, received chemotherapy (OS difference 9.4 months, P = .024), or monoclonal antibodies (trastuzumab ± pertuzumab; OS difference 6.1 months; P = .013) after LM diagnosis, had a statistically significantly longer OS. Presence of neurological symptoms (hazard ratio 3.32, 95% CI 1.26‐8.73; P = .015) and not having received radiotherapy (hazard ratio 2.02, 95% CI 1.09‐3.72; P = .024) were all associated with poorer OS at multivariate analysis. To summarize, not having neurological symptoms and receiving RT at LM diagnosis were associated with prolonged OS in our cohort. Survival seemed to be prolonged with multimodality treatment, which included targeted therapy, chemotherapy, and RT to the LM sites.
Exploring the Chemical Space of Urease Inhibitors to Extract Meaningful Trends and Drivers of Activity

Blocking the catalytic activity of urease has been shown to have a key role in different diseases as well as in different agricultural applications. A vast array of molecules have been tested against ureases of different species, but the clinical translation of these compounds has been limited due to challenges of potency, chemical and metabolic stability as well as promiscuity against other proteins. The design and development of new compounds greatly benefit from insights from previously tested compounds; however, no large-scale studies surveying the urease inhibitors’ chemical space exist that can provide an overview of developed compounds to data. Therefore, given the increasing interest in developing new compounds for this target, we carried out a comprehensive analysis of the activity landscape published so far. To do so, we assembled and curated a data set of compounds tested against urease. To the best of our knowledge, this is the largest data set of urease inhibitors to date, composed of 3200 compounds of diverse structures. We characterized the data set in terms of chemical space coverage, molecular scaffolds, distribution with respect to physicochemical properties, as well as temporal trends of drug development. Through these analyses, we highlighted different substructures and functional groups responsible for distinct activity and inactivity against ureases. Furthermore, activity cliffs were assessed, and the chemical space of urease inhibitors was compared to DrugBank. Finally, we extracted meaningful patterns associated with activity using a decision tree algorithm. Overall, this study provides a critical overview of urease inhibitor research carried out in the last few decades and enabled finding underlying SAR patterns such as under-reported chemical functional groups that contribute to the overall activity. With this work, we propose different rules and practical implications that can guide the design or selection of novel compounds to be screened as well as lead optimization.
The impact of open versus closed weighing on rate of weight gain and length of stay among inpatients with anorexia nervosa

ABSTRACT Anorexia nervosa (AN) is a serious illness associated with significant morbidity and mortality. Few data exist to guide practice regarding sharing daily weight information (open weighing) or withholding it (closed weighing) from patients. We investigated the effect of open versus closed weighing on weight-related outcomes among inpatients with AN. Data were collected during a 4-month period when 43 patients were not told their daily weight, and a consecutive 4-month period when 41 patients were told their weights during rounds. There was no significant difference in mean overall weight change (3.6 ± 2.7 kg vs. 3.5 ± 2.5 kg), hospital duration (14.3 ± 10.0 vs. 14.2 ± 7.6 days), or rate of weight gain (0.26 ± 0.11 vs. 0.25 ± 0.13 kg) between groups. It is possible that one weighing procedure may not be preferable with respect to certain clinical outcomes for inpatients with AN, suggesting there may be multiple ways to navigate the discussion of weight progress in weight restoration programs.
Prolactin and maternal metabolism in women with a recent GDM pregnancy and links to future T2D: the SWIFT study.

OBJECTIVE Prolactin is a multifaceted hormone known to regulate lactation. In women with gestational diabetes mellitus (GDM) history, intensive lactation has been associated with lower relative risk of future type 2 diabetes (T2D). However, the role of prolactin in T2D development and maternal metabolism in women with a recent GDM pregnancy has not been ascertained. METHODS We utilized a prospective GDM cohort (the SWIFT study), and participants were followed up for T2D onset by performing 2-hour 75-g oral glucose tolerance test (OGTT) and retrieving clinical diagnoses of T2D from electronic medical records. Targeted metabolomics and lipidomics were applied on fasting plasma samples collected at study baseline (6-9 weeks postpartum) in a nested case-control study (100 future T2D cases vs. 100 no T2D controls). RESULTS The relationship among prolactin, future T2D risk and key clinical metabolic parameters were first examined. Importantly, decreasing prolactin quartiles were associated with increased future T2D risk (adjusted odds ratio 2.48, 95% CI 0.81-7.58, p=0.05). In women who maintained normoglycemia during the 10-year follow-up, higher prolactin at baseline was associated with higher insulin sensitivity (p = 0.038) and HDL-C (p = 0.01), but lower BMI (p = 0.001) and leptin (p = 0.002). Remarkably, among women who developed future T2D, prolactin was not correlated with a favourable metabolic status (all p> 0.05). Then, by applying metabolomics and lipidomics, we found lower circulating prolactin was strongly correlated with a T2D-high risk lipid profile; elevated circulating neutral lipids and lower concentrations of specific phospholipids/sphingolipids. CONCLUSION In women with recent GDM pregnancy, low circulating prolactin is associated with specific clinical parameters and lipid metabolites linked to a high risk of developing T2D.
The reduction of oocytes and disruption of the meiotic prophase I in Fanconi Anemia E deficient mice.

Fance is an important factor participating in the repair of DNA interstrand cross-links and its defect causes severe follicle depletion in female mice. To explore the underlying mechanisms, we investigated the effects of Fance on ovarian development in embryonic and newborn mice. We found that the number of oocytes was significantly decreased in Fance-/- mice as early as 13.5 days post coitum (dpc). The continuous decrease of oocytes in Fance-/- mice compared with the Fance+/+ mice led to the primordial follicles being almost exhausted at 2 days postpartum (dpp). The mitotic-meiotic transition occurred normally, but the meiotic progression was arrested in pachytene in Fance-/- oocytes. We detected the expressions of RAD51 (homologous recombination repair factor), 53BP1 (non-homologous end-joining repair factor), and γH2AX by immunostaining analysis and chromosome spreads. The expressions of 53BP1 were increased and RAD51 decreased significantly in Fance-/- oocytes compared with Fance+/+ oocytes. Also, the meiotic crossover indicated by MLH1 foci was significantly increased in Fance-/- oocytes. Oocyte proliferation and apoptosis were comparable between Fance-/- and Fance+/+ mice (P>0.05). The aberrant high expression at 17.5dpc and low expressions at 1dpp and 2dpp indicated the expression pattern of pluripotent marker OCT4 was disordered in Fance-/- oocytes. These findings elucidate that Fance mutation leads to a progressive reduction of oocytes and disrupts the progression of meiotic prophase I but not the initiation. And our study reveals that the potential mechanisms involve DNA damage repair, meiotic crossover, and pluripotency of oocytes.