Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychological Discomfort in Nursing Degree Students as a Consequence of the COVID-19 Pandemic

Students are a population at risk of developing psychological complications, such as psychological discomfort, stress, and anxiety, among other problems, especially during the current health crisis due to the COVID-19 pandemic. The present study’s objective was to analyze the effects of the COVID-19 pandemic on the psychological discomfort of final-year nursing students. A cross-sectional descriptive observational study was carried out. To analyze the psychological discomfort of the participants, the Kessler test (previously validated) was used. The results of this test were divided into two levels (High ≥ 21/Low < 21), showing high sensitivity as a screening method for anxiety and depression. Questionnaires were sent via email to final-year nursing students of Spanish and South American universities, inviting them to participate voluntarily. The sample consisted of 400 students, with an average age of 23.29 years and a sex proportion of 82.75% women and 17.28% men. Almost all participants (n = 396) belonged to Spanish universities, and the greatest participation corresponded to Andalusian universities (64.5%). The average psychological discomfort was high (M = 27.94). Statistically significant relationships were detected between age, sex, and feeling ready for the world of work, observing no relationships with the rest of the studied variables. The sample of 4th-year students of the Degree of Nursing presented a high level of psychological discomfort. This pathology does not seem to be related to having suffered from COVID-19 or being in contact with infected people during the practicum and is more strongly related to personal sociodemographic variables and students’ preparation for the world of work.
Forecasting e-Journal Unique Visitors using Smoothed Long Short-Term Memory

The number of unique visitors every day can be used as a benchmark to assess the success of an electronic journal. Unique visitors are visitors who use one IP in a certain period. With an increasing number of unique visitors every day, it can be inferred that scientific periodicals are increasingly in demand by the wider community, affecting the breadth of distribution and speeding up the journal accreditation system. Therefore, a model that can predict the number of unique visitors in electronic journals in the future can be beneficial for journal administrators. This paper evaluates Long Short-Term Memory (LSTM) performance when predicting the next day’s (T+1) time series for the number of unique visitors to an e-Journal website. The unique visitor data sample used was from January 1, 2018, to December 31, 2018. The distribution of data testing and training used was 80% and 20%. The data quality has been improved by smoothing the input data using exponential, mean, and median smoothing. The evaluation results show that the architecture with the best performance is model 2, namely the model mean + LSTM architecture 1-5-1 with a learning rate of 0.2 and a MAPE value of 0.08098. Therefore, we conclude that data smoothing with mean smoothing can improve Long Short-Term Memory performance for unique website visitor forecasting.
Cell Strain-Derived Induced Pluripotent Stem Cells as an Isogenic Approach To Investigate Age-Related Host Response to Flaviviral Infection

Aging has been a risk factor for poor clinical outcome in several infectious diseases, including dengue. However, age-dependent responses to dengue and other flaviviral infection or vaccination have remained incompletely understood due partly to lack of suitable laboratory tools. ABSTRACT The expansion of the geographical footprint of dengue viruses (DENVs) and their mosquito vectors have affected more than half of the global population, including older adults who appear to show elevated risk of severe dengue. Despite this epidemiological trend, how aging contributes to increased dengue pathogenesis is poorly understood. A limitation has been the lack of useful in vitro experimental approaches; cell lines commonly used for infection studies are immortal and hence do not age. Cell strains such as WI-38 and MRC-5 with diploid genomes do age with in vitro passaging, but these cell strains were isolated decades ago and are now mostly highly passaged. Here, we show that reprogramming of cell strains with finite life span into induced pluripotent stem cells (iPSCs), followed by conversion back into terminally differentiated cells, can be an approach to derive genetically identical cells at different stages of aging. The iPSC-derived differentiated cells were susceptible to wild-type DENV infection and produced greater levels of type I interferon expression with increased passaging, despite similar levels of infection. In contrast, infection with the attenuated DENV-2 PDK53 and YF17D-204 strains showed reduced and increased levels of infection with increasing passages, respectively; the latter could be clinically pertinent, as YF17D-204 vaccination in older adults is associated with increased risk of severe adverse outcome. The differences in infection susceptibility and host response collectively suggest the potential of iPSC-derived cell strains as a genetically controlled approach to understanding how aging impacts viral pathogenesis. IMPORTANCE Aging has been a risk factor for poor clinical outcome in several infectious diseases, including dengue. However, age-dependent responses to dengue and other flaviviral infection or vaccination have remained incompletely understood due partly to lack of suitable laboratory tools. We thus developed an in vitro approach to examine age-related changes in host response to flaviviral infection. Notably, this approach uses cell strains with diploid rather than aneuploidic genomes, which are unstable. Conversion of these cells into iPSCs ensures sustainability of this resource, and reprogramming back into terminally differentiated cells would, even with a limited number of passages, produce cells at different stages of aging for infection studies. Our findings suggest that this in vitro system has the potential to serve as a genetically controlled approach to define the age-related response to flavivirus infection.
Seaweed Blends as a Valuable Source of Polyunsaturated and Healthy Fats for Nutritional and Food Applications

Seaweeds are considered healthy and sustainable food. Although their consumption is modest in Western countries, the demand for seaweed in food markets is increasing in Europe. Each seaweed species has unique nutritional and functional features. The preparation of blends, obtained by mixing several seaweeds species, allows the obtaining of maximum benefits and ingredients with single characteristics. In this work, five seaweed blends, commercially available and produced under organic conditions in Europe, were characterized. The proximal composition included contents of ash (20.28–28.68% DW), proteins (17.79–26.61% DW), lipids (0.55–1.50% DW), and total carbohydrates (39.47–47.37% DW). Fatty acid profiles were determined by gas chromatography–mass spectrometry (GC–MS), allowing quantification of healthy fatty acids, namely n-3 and n-6 polyunsaturated fatty acids (PUFA), and calculation of lipid quality indices. Each blend showed a characteristic PUFA content in the lipid pool (35.77–49.43% of total fatty acids) and the content in essential and healthy n-3 PUFA is highlighted. The atherogenicity (0.54–0.72) and thrombogenicity (0.23–0.45) indices evidenced a good nutritional value of lipid fractions. As nutritional and environmentally attractive products, the consumption of the studied seaweed blends can contribute to a healthy lifestyle.
Recent Progress in Applicability of Exercise Immunology and Inflammation Research to Sports Nutrition

This article focuses on how nutrition may help prevent and/or assist with recovery from the harmful effects of strenuous acute exercise and physical training (decreased immunity, organ injury, inflammation, oxidative stress, and fatigue), with a focus on nutritional supplements. First, the effects of ketogenic diets on metabolism and inflammation are considered. Second, the effects of various supplements on immune function are discussed, including antioxidant defense modulators (vitamin C, sulforaphane, taheebo), and inflammation reducers (colostrum and hyperimmunized milk). Third, how 3-hydroxy-3-methyl butyrate monohydrate (HMB) may offset muscle damage is reviewed. Fourth and finally, the relationship between exercise, nutrition and COVID-19 infection is briefly mentioned. While additional verification of the safety and efficacy of these supplements is still necessary, current evidence suggests that these supplements have potential applications for health promotion and disease prevention among athletes and more diverse populations.
Discovery of Novel Dihydrolipoamide S-Succinyltransferase Inhibitors Based on Fragment Virtual Screening

A series of new oxadiazole sulfone derivatives containing an amide moiety was synthesized based on fragment virtual screening to screen high-efficiency antibacterial agents for rice bacterial diseases. All target compounds showed greater bactericidal activity than commercial bactericides. 3-(4-fluorophenyl)-N-((5-(methylsulfonyl)-1,3,4-oxadiazol-2-yl)methyl)acrylamide (10) showed excellent antibacterial activity against Xanthomonas oryzae pv. oryzae and Xanthomonas oryzae pv. oryzicola, with EC50 values of 0.36 and 0.53 mg/L, respectively, which were superior to thiodiazole copper (113.38 and 131.54 mg/L) and bismerthiazol (83.07 and 105.90 mg/L). The protective activity of compound 10 against rice bacterial leaf blight and rice bacterial leaf streak was 43.2% and 53.6%, respectively, which was superior to that of JHXJZ (34.1% and 26.4%) and thiodiazole copper (33.0% and 30.2%). The curative activity of compound 10 against rice bacterial leaf blight and rice bacterial leaf streak was 44.5% and 51.7%, respectively, which was superior to that of JHXJZ (32.6% and 24.4%) and thiodiazole copper (27.1% and 28.6%). Moreover, compound 10 might inhibit the growth of Xanthomonas oryzae pv. oryzae and Xanthomonas oryzae pv. oryzicola by affecting the extracellular polysaccharides, destroying cell membranes, and inhibiting the enzyme activity of dihydrolipoamide S-succinyltransferase.
Energy effect of the laser-induced vertical metallic link

In this paper, the energy effect of the laser vertical metallic link is investigated from a microscopic point of view through experimental observations and simulations. Sample structures that were irradiated under different laser energies were cross-sectioned and observed using a FIB/SEM dual-beam system. Failure criterion at the high energy level was defined by excessive material loss in the lower metal (metal 1) and passivation cracking. Micro-images also suggest that, for an optimal link metal (metal 2) opening should be larger than the lower metal linewidth considering the dielectric-step-induced lens effect. Taking into account both measured electrical resistance and observed voids in the lower metal, the normalized energy process window is defined to be the absolute energy range divided by the average energy. For the structures with 1-, 2-, 3-, and 4-/spl mu/m lower metal linewidths, the relative process windows are 0.83, 0.87, 0.9, and 0.96, respectively. Simulations also revealed consistent results with the experimental observations, which is a monotonically decreasing trend of relative energy process windows for more scaled links. A simple equation to evaluate the spot size of the laser beam for various link structures is presented. These results demonstrate the application of commercially viable vertical linking technology to VLSI applications.
Reliability of Sit to Stand Test in Fall Identification in Knee Osteoarthritis- A Literature Review

Osteoarthritis is the second most prevalent degenerative illness as well as the most frequent joint condition in India. It is one of the most common degenerative disorder of the articular cartilage and surface of weightbearing joints causing disability in elderly patients. Gait, stair-climbing, unipedal stance, and the sitting-to-standing (STS) task have all been shown to be altered in research. Most of the research article had proved that sit to stand test, we can use to physiotherapy department to identify the risk of fall in knee OA patients. Most of the patients had severe knee pain and reduced lower limb muscle strength so, during the test patient may take a long time to complete the test and there is a loss of balance. Due to pain and reduced endurance and loss of balance, the patient may not be capable of completing the test. So, the test is reliable to determine the risk of a fall in knee OA patient.
Depression and Functional Mobility Decline in Long Term Care Home Residents with Dementia: a Prospective Cohort Study

Objective Assess the association between depression among new long-term care residents (<3 months stay) with dementia and functional mobility decline. Methods A multi-site prospective cohort study was carried out among 26 participants diagnosed with dementia. Functional mobility was measured by Timed-Up-and-Go (TUG) and 2-Minute walk test (2MWT) at baseline, and 60-day post-baseline while participants received usual care. Linear mixed models were applied to examine the association between depression and functional mobility decline. Results Residents experienced a statistically significant decline in functional mobility in as soon as 60 days. Each additional year of age was associated with a 2% increase in TUG. The interaction between depression and time spent in LTC was statistically significant. Age and time living in LTC were significantly associated with functional mobility decline in new residents with dementia. Discussion Further work determining why residents with dementia experience decline in functional mobility at an accelerated rate is needed.
Effects of probiotic supplements on growth performance and intestinal microbiota of partridge shank broiler chicks

Background The benefits of probiotics being used in animals are well-documented via evidenced growth performance improvement and positive modulations of gut microbiota (GM). Thus, a combination of effective microorganisms (EM) has been frequently used in animal production, including broilers. However, there are only very limited reports of EM on the growth performance and the modulation in GM of partridge shank broiler chicks. Methods We attempted to evaluate the effects of a basal diet with the addition of an EM mixture on the growth performance and gut microbiome of the chicks. A total of 100 ten-day-old female partridge shank broiler chicks were randomly divided into two groups of 50 chicks each, of which, one group fed with EM supplementation in the basal diet (designated as EM-treated group), the other group just fed with a basal diet (referred as to non-EM treated group or control group). The body weight, daily feed intake, daily gain, feed conversion ratio and other growth parameters were observed and compared between EM-treated and non-EM-treated chicks, and the gut microbiota was profiled by 16S rRNA-based next generation sequencing (NGS). Results EM-treated chicks showed significantly increased performances in body weight (BW), average daily gain (ADG) and reduced feed conversion ratio (FCR). Histological observation indicated that dietary supplementation of EM significantly increased the villus heights (VH) and the ratio of villus height to crypt depth (VH/CD), while decreased the CD of jejunum, ilea, and ceca. The results of 16S rRNA-based gut microbiota analyses showed that Firmicutes accounted for the most of the relative abundance (63.24%∼92.63%), followed by Proteobacteria (0.62%∼23.94%), Bacteroidetes (0.80%∼7.85%), Actinobacteria (0.06%∼13.69%) and others in both EM-treated and non-EM-treated broiler chicks. The addition of EM could not alter the alpha diversity of gut microbiota. Compared with the non-EM-treated chicks, the abundances of bad bacteria in the phyla of Firmicutes, Euryarchaeota, and Ruminococcus were dramatically decreased in that of EM-treated chicks, while the abundances of good bacteria in the phyla of Actinobacteria and WPS-2 were significantly increased. Conclusions The supplementation of EM in feed could improve the growth performance and positively influence the morphological characteristics of the intestine, and ameliorate the community and structure of the intestinal microbiota of partridge shank broiler chicks.
Dynamic Shapley Value in the Game with Perishable Goods

The paper investigates two-stage stochastic minimum spanning tree games with perishable goods. The cooperative behaviour of the players is defined. At each stage, all players jointly take action to construct a network with a cost matrix. At the second stage, a particular player may leave the game, and the probability of this leaving depends on the cooperative behaviour of all players at the first stage. At each stage game, the total cost of the spanning tree is calculated to include the sum of the costs of the contained edges and the cost of the loss of perishable goods expended on that edge of the spanning tree. The characteristic functions in the game are considered, and the dynamic Shapley values are modified. The time consistency of the dynamic Shapley values is studied.
Management of Probability of Desired Invention during Hackathon

ABSTRACT The quest for invention has become crucial for the economic development, with the rise of IT technologies and the process of innovation becoming shorter. Hackathon has proven to be a novel invention development method, yet its popularity posed a major challenge of standardization and management. This paper analyses research performed on 14 hackathons, which leads to a deeper understating of processes within the hackathon method. An introduction to the relationship between hackathon approaches, types, and invention development process are presented. The hackathon invention framework and the hackathon equilibrium management concept are introduced allowing for the understanding of how different preparations and decisions may determine the expectations and the probability of the desired invention as the result of the hackathon.
The perception of hazard II. The contribution of signal detection to hazard perception

Abstract Visual warning signals associated with rockfalls in deep-level gold mining are embedded in a misleading and competing background. Due to the relatively high incidence of rockfall accidents and the relatively high involvement of novice mine workers in accidents, the ability of mine workers to discriminate visually between dangerous and safe rock conditions was examined. Stimuli were presented to participants with the aid of stereoscopic slides and responses were analysed in terms of the Theory of Signal Detection. The results confirmed the contention that underground experience as well as skills training improves significantly the ability of mine workers to discriminate visually between dangerous and safe rock.
Identification of Candidate Variants Associated With Bone Weight Using Whole Genome Sequence in Beef Cattle

Bone weight is critical to affect body conformation and stature in cattle. In this study, we conducted a genome-wide association study for bone weight in Chinese Simmental beef cattle based on the imputed sequence variants. We identified 364 variants associated with bone weight, while 350 of them were not included in the Illumina BovineHD SNP array, and several candidate genes and GO terms were captured to be associated with bone weight. Remarkably, we identified four potential variants in a candidate region on BTA6 using Bayesian fine-mapping. Several important candidate genes were captured, including LAP3, MED28, NCAPG, LCORL, SLIT2, and IBSP, which have been previously reported to be associated with carcass traits, body measurements, and growth traits. Notably, we found that the transcription factors related to MED28 and LCORL showed high conservation across multiple species. Our findings provide some valuable information for understanding the genetic basis of body stature in beef cattle.
Genipin-Based Crosslinking of Jellyfish Collagen 3D Hydrogels

Collagen-based hydrogels are an attractive option in the field of cartilage regeneration with features of high biocompatibility and low immunogenic response. Crosslinking treatments are often employed to create stable 3D gels that can support and facilitate cell embodiment. In this study, we explored the properties of JellaGel™, a novel jellyfish material extracted from Rhizostoma pulmo. In particular, we analyzed the influence of genipin, a natural crosslinker, on the formation of 3D stable JellaGel™ hydrogels embedding human chondrocytes. Three concentrations of genipin were used for this purpose (1 mM, 2.5 mM, and 5 mM). Morphological, thermal, and mechanical properties were investigated for the crosslinked materials. The metabolic activity of embedded chondrocytes was also evaluated at different time points (3, 7, and 14 days). Non-crosslinked hydrogels resulted in an unstable matrix, while genipin-crosslinked hydrogels resulted in a stable matrix, without significant changes in their properties; their collagen network revealed characteristic dimensions in the order of 20 µm, while their denaturation temperature was 57 °C. After 7 and 14 days of culture, chondrocytes showed a significantly higher metabolic activity within the hydrogels crosslinked with 1 mM genipin, compared to those crosslinked with 5 mM genipin.
Research on mechanical properties and acoustic emission characteristics of rock beams with different lithologies and thicknesses

The lithology and thickness of the rock beam affect its mechanical properties and acoustic emission characteristics when it is fractured. In this study, three-point bending tests of rock beams were carried out. Then, we proposed to utilize the percentage of peak energy to characterize the intensity of energy release during fracture. Finally, the energy release mechanism of coal roof fracture was discussed. The evolution process of acoustic emission includes five stages. The acoustic emission amplitude distribution of rock beams has three typical patterns. Most of the cracks after fracture are tensile cracks, the proportion of tensile cracks is positively correlated with the elastic modulus. The percentage of peak energy is positively correlated with thickness and elastic modulus. More energy is released when thick and hard roof fractures. When necessary, measures such as reducing the thickness or the strength of the roof could be taken to improve the safety of mining.
A theoretical study of the input impedance of a circular microstrip disk antenna

A theoretical study is presented of the input impedance of a circular microstrip disk antenna excited by a coaxial line. The theory is based on Green's function technique applied to the disk cavity with the boundary admittance at the edge. Both the feed pin size and the boundary admittance are shown to be important in deriving the analytical expression for the input impedance. The boundary admittance is obtained by considering the radiated power and the electric and magnetic stored energies in the fringe capacitance. The analytical expression for the input impedance includes the feed location, the feed pin size, the disk size and thickness, and the dielectric constant of the material, and is useful for optimizing various parameters. The calculations are compared with experimental data showing a good agreement.
Fixed points of C 2 maps

S. N. Chow and J. A. Yorke have proposed in abstract terms an algorithm for computing fixed points of C 2 maps that is globally convergent with probability one. A numerical implementation of that algorithm is presented here, where careful attention has been paid to computational efficiency, accuracy, and robustness. Convergence proofs for the numerical algorithm require differential geometry, and are given elsewhere. FORTRAN subroutines are given and explained in detail, and some typical numerical results are presented. It is shown how to modify the subroutines to compute zeros and handle some large sparse problems.