Miracle-dz/UniFAR-FTUs huggingface dataset:
A Model-Based Analysis of Capacitive Flow Metering for Pneumatic Conveying Systems: A Comparison between Calibration-Based and Tomographic Approaches

Pneumatic conveying is a standard transportation technique for bulk materials in various industrial fields. Flow metering is crucial for the efficient and reliable operation of such systems and for process control. Capacitive measurement systems are often proposed for this application. In this method, electrodes are placed on the conveyor systems transport line and capacitive signals are sensed. The design of the sensor with regard to the arrangement and the number of electrodes as well as the evaluation of the capacitive sensor signals can be divided into two categories. Calibration-based flow meters use regression methods for signal processing, which are parametrized from calibration measurements on test rigs. Their performance is limited by the extend of the calibration measurements. Electrical capacitance tomography based flow meters use model-based signal processing techniques to obtain estimates about the spatial material distribution within the sensor. In contrast to their calibration-based counterparts, this approach requires more effort with respect to modeling and instrumentation, as typically a larger number of measurement signals has to be acquired. In this work we present a comparative analysis of the two approaches, which is based on measurement experiments and a holistic system model for flow metering. For the model-based analysis Monte Carlo simulations are conducted, where randomly generated pneumatic conveying flow patterns are simulated to analyze the sensor and algorithm behavior. The results demonstrate the potential benefit of electrical capacitance tomography based flow meters over a calibration-based instrument design.
Semaphorin 3F induces colorectal cancer cell chemosensitivity by promoting P27 nuclear export

Colorectal adenocarcinoma (CRC) is the third most common malignancy worldwide. Metastatic CRC has a poor prognosis because of chemotherapy resistance. Our previous study demonstrated that semaphorin 3F (SEMA3F) signaling may contribute to reversing chemotherapy resistance in CRC cells by reducing E-cadherin and integrin αvβ3 expression levels. Another study showed that upregulation of p27 significantly increase the expression of E-cadherin and integrin. This study aimed to evaluate the effect of SEMA3F on P27 and whether it can reverse resistance in CRC cells. We compared the chemosensitivity of human colorectal cancer cell lines with different SEMA3F expression levels to 5-Fu through cell experiment and animal experiment. Then the interaction between SEMA3F and p27 and its possible mechanism were explored by Western Blot, immunofluorescence and immunocoprecipitation. We also compared the disease-free survival of 118 CRC patients with high or low expression of SEMA3F.The results showed that overexpresstion of SEMA3F enhanced the chemotherapy sensitivity and apoptosis of CRC cells in vitro and in vivo. Among 118 postoperative CRC specimens, the disease-free survival of patients with positive SEMA3F expression was significantly longer than that with negative SEMA3F expression after adjuvant treatment. Upregulation of SEMA3F in multicellular spheroid culture (MSC) could increase p27 phosphorylation at serine 10 (Ser10), subsequently promote the cytosolic translocation of P27. Overall, our results reveal a novel molecular mechanism: SEMA3F mediates the degradation of p27 and regulates its subcellular localization to enhance chemosensitivity to 5-Fu in CRC cells, rather than inhibits p27 expression.
Biodiversidad bacteriana presente en suelos contaminados con hidrocarburos para realizar biorremediación

[Introducción]: La biorremediación es una tecnología que utiliza microorganismos (bacterias, hongos, algas) o enzimas, para biodegradar contaminantes del petróleo y derivados y como otros contaminantes que están presentes en suelo, aire o agua. En América Latina existe un alto grado de contaminación de sus ecosistemas; por tanto, esta tecnología es viable económica y ambientalmente para degradar contaminantes. Los hidrocarburos aromáticos policíclicos como asfaltenos y resinas son difíciles de degradar, así como los alifáticos y bifenilos policlorados. [Objetivo]: Se busca dar una visión general de las publicaciones recientes sobre investigaciones científicas realizadas, y metodologías de biorremediación de suelos contaminados por petróleo y sus derivados. [Metodología]: Se realizó una búsqueda exhaustiva de la literatura científica de los últimos años, relacionado al tema propuesto en bases de datos bibliográficas: Medline, Current Contents, PubMed, Google scholar, SciFinder, Scopus y en revistas especializadas: Chemosphere, Microbiología Aplicada, Biodegradation & Biodeterior, Sociedad Americana de Microbiología, Microbiología Frontal, Sci Total Environ. Las palabras clave utilizadas fueron en español o inglés. [Resultados]: Los hidrocarburos poliaromáticos pueden ser biodegradados por diferentes bacterias que biodegradan solas o en consorcio, como el fenantreno (compuesto aromático) que fue biodegradado por 11 cepas bacterianas diferentes (Sphingobium, Sphingomonas, Acidovorax, Alkaligenes, Actinobacteria, Burkholderia sp., Rhizobium sp., Pseudomonas sp., Stenotrophomonas y Sinorhizobium). En biorremediación se considera importante las variables fisicoquímicas, como el pH, temperatura, oxígeno y la humedad, al ser factores que influyen en el éxito del tratamiento. [Conclusiones]: Se buscó aportar con esta revisión, soluciones viables a variados problemas de contaminación por hidrocarburos de los ecosistemas latinoamericanos.
Method to Identify the Likelihood of Death in Residential Buildings during Coastal Flooding

Tools exist to predict fatalities related to floods, but current models do not focus on fatalities in buildings. For example, Storm Xynthia in France in 2010 resulted in 41 drowning deaths inside buildings. Therefore, there has been increasing recognition of the risk of people becoming trapped in buildings during floods. To identify buildings which could expose their occupants to a risk of death in the case of flooding, we propose the use of the extreme vulnerability index (VIE index), which identifies which buildings are at greatest risk of trapping people during floods. In addition, the “mortality function method” is used to further estimate the expected number of fatalities based on (1) groups of vulnerable people (e.g., aged or disabled), (2) the location of buildings in relation to major watercourses, and (3) the configuration of buildings (e.g., single or multiple entries and single or multiple stories). The overall framework is derived from case studies from Storm Xynthia which give a deterministic approach for deaths inside buildings for coastal floods, which is suited for low-lying areas protected by walls or sandy barriers. This methodology provides a tool which could help make decisions for adaptation strategy implementation to preserve human life.
Vicarious attention, degrees of enhancement, and the contents of consciousness

How are attention and consciousness related? Can we learn what the contents of someone’s consciousness are if we know the targets of their attention? What can we learn about the contents of consciousness if we know the targets of attention? Although introspection might suggest that attention and consciousness are intimately connected, a good body of recent findings in cognitive psychology and cognitive neuroscience brings compelling reasons to believe that they are two separate and independent processes. This paper attempts to bring attention and consciousness back together to make the study of attentional distributions an essential ingredient for the study of the contents of consciousness. My proposal has two main components. First, I introduce a framework for systematizing the relations between attention in its different forms and consciousness in its different forms. Although philosophers and cognitive scientists have repeatedly highlighted the importance of such systematization, most details are still to be worked out. Here I take an initial stab at this project based on the notion of degrees of informational enhancement. Second, I introduce the notion of vicarious attention to account for a kind of additional processing benefit that comes for free when attention is allocated to a target. I then propose that this kind of processing must also be considered when mapping attention targets into contents of consciousness.
The Unexpected Formation of a Broncho-Esophageal Fistula of the Right Main Stem Bronchus Status Post Esophageal Stent Placement: A Case Report

This case presents a patient with a history of non-small cell lung carcinoma who had radiation therapy complicated by esophageal dysphagia. She had a fully covered self-expanding metal stent (SEMS) placed one year ago in the proximal region of her esophagus prior to this admission. She presented to the emergency department (ED) for dyspnea on exertion. Imaging showed a persistent right lower lobe opacity, and bronchoscopy revealed a right broncho-esophageal fistula (BEF). Further investigation by endoscopy found that the fully covered SEMS migrated distally and caused the formation of her fistula. This case presents a patient with a right BEF caused by a migrating esophageal stent.
Technological learning potential of offshore wind technology and underlying cost drivers

Detailed analysis of technological learning of energy technologies is scarce. For floating wind, this is missing altogether. In this study, we applied experience curve and bottom-up cost modeling methodologies and assessed the long-term cost reduction potential of fixed-bottom and floating offshore wind in their mature markets. The contributing factors to cost reduction are also quantified and elaborated. Further, to emphasize the role of strongly varying site characteristics of offshore wind farms and their influences, the grid connection cost is separately discussed from the total technology costs (Capital Expenditure and LCoE). Our assessment shows that, excluding grid connection costs, fixed-bottom offshore wind LCoE is 40 €/MWh at 31 GW cumulative capacity (2023–2024) and decline to 28 ± 3 €/MWh by 100 GW. Floating wind LCoE is 123 €/MWh at 1 GW cumulative capacity (2027 – 2030) but decline to 33 ± 6 €/MWh by 100 GW. Moreover, floating wind can achieve cost parity (i.e., 40 €/MWh, excl. grid connection cost) by deploying 21 GW, requiring 44 billion € of learning investment in the form of subsidies to compensate the price gap for the technology in the energy system. Lastly, we analyzed the grid connection costs and their influencing factors, and then determined that an integrated offshore grid would be needed to efficiently connect future offshore wind farms to the onshore grid.
Neurotoxicity related exposure to ambient nanoparticles

Air pollution exposure is among the most prevalent reasons for environmentally-induced oxidative stress and inflammation, both of which are implicated in the central nervous system (CNS) diseases. The CNS has emerged as an important target for adverse health effects of exposure to air pollutants, where it can cause neurological and neurodevelopmental disorders. Air pollution includes various components of gases, particulate matter (PM), ultraﬁne particulate (UFPs), metals, and organic compounds. An important source of PM and UFPM in the ambient air is associated with air pollution-related trafficking, and primarily diesel exhaust particles (DEPs). Controlled animal studies and epidemiological studies show that exposure to air pollution, and in particular urban air pollution or DEPs, may lead to neurotoxicity. In specific, exposure to air pollutants as an important factor may be in neurodevelopmental disorders (eg Autism) and neurological disorders (eg., Alzheimer’s Disease (AD)). The most noticeable effects of exposure to air pollutants in animals and humans are oxidative stress and neurodegeneration. Studies in rats exposed to DEPs showed microglial activity, increased lipid peroxidation, and neuronal accumulation in various areas of the brain, especially the olfactory bulb (OB) and the hippocampus (HI). Disorders of adult neurogenesis were also found. In most cases, the effects of DEP are more pronounced in male mice, probably due to lower antioxidant capacity due to less expression of paraoxonase 2.
Computer Incident Response and Forensics Team Management: Conducting a Successful Incident Response

Computer Incident Response and Forensics Team Management provides security professionals with a complete handbook of computer incident response from the perspective of forensics team management. This unique approach teaches readers the concepts and principles they need to conduct a successful incident response investigation, ensuring that proven policies and procedures are established and followed by all team members. Leighton R. Johnson III describes the processes within an incident response event and shows the crucial importance of skillful forensics team management, including when and where the transition to forensics investigation should occur during an incident response event. The book also provides discussions of key incident response components. Provides readers with a complete handbook on computer incident response from the perspective of forensics team managementIdentify the key steps to completing a successful computer incident response investigation Defines the qualities necessary to become a successful forensics investigation team member, as well as the interpersonal relationship skills necessary for successful incident response and forensics investigation teams
A hermeneutic analysis of the Denver international baggage handling system

This paper attempts to demonstrate the principles of hermeneutics in an effort to understand factors affecting Information Systems (IS) projects. As hermeneutics provides a systematic method of interpreting text from multiple information sources, thus, Information Systems being prima facie defined and documented as text documents, are eminently suited for this mode of investigation. In this paper, we illustrate hermeneutics by analysing a sample case study document describing a well known project of Denver International Airport (DIA) Automated Baggage Handling System, which was extensively reported in IS and management press and studied by Montealegre and his colleagues (Montealegre, Nelson, Knoop, & Applegate, 1999, p553-554). As a result of the hermeneutic approach to the analysis of this document, a new "flexibility" factor has been discovered to play an important, yet unreported, role in the DIA system demise. In the DIA case, the observed flexibility factor influenced the quality of the interaction between the actors, the prevailing environment and the information systems.
Effect of Viscosity on High-Throughput Deterministic Lateral Displacement (DLD)

Biosample analysis often requires the purification, separation, or fractionation of a biofluid prior to transport to the biosensor. Deterministic lateral displacement (DLD) is a size-based microfluidic separation technique that shows promise for biosample preparation. Recently, high-throughput DLD separation has been demonstrated with airfoil-shaped pillars at higher flow rates, but this also changes separation dynamics as the Reynolds number (Re) increases. In this work, the particle trajectories in the airfoil DLD with two different angle-of-attacks (AoAs) were studied at a range of Re with alterations of fluid viscosity to mimic biological fluids. Previous studies have found that the critical diameter (Dc) decreases as Re climes. We demonstrated that variations of the fluid viscosity do not alter the separation dynamics if the Re is kept constant. As the associated Re of the flow increases, the Dc decreases regardless of viscosity. The negative AoA with an airfoil DLD pillar design provided the stronger Dc shift to negate pressure increases.
A Versatile Strategy for the Fabrication of Poly(ethyl methacrylate) Composites

Poly(ethyl methacrylate) (PEMA) is dissolved in ethanol, known to be a non-solvent for PEMA, due to the solubilizing ability of an added bile acid biosurfactant, lithocholic acid (LA). The ability to avoid traditional toxic and carcinogenic solvents is important for the fabrication of composites for biomedical applications. The formation of concentrated solutions of high molecular weight PEMA is a key factor for the film deposition using the dip coating method. PEMA films provide corrosion protection for stainless steel. Composite films are prepared, containing bioceramics, such as hydroxyapatite and silica, for biomedical applications. LA facilitates dispersion of hydroxyapatite and silica in suspensions for film deposition. Ibuprofen and tetracycline are used as model drugs for the fabrication of composite films. PEMA-nanocellulose films are successfully prepared using the dip coating method. The microstructure and composition of the films are investigated. The conceptually new approach developed in this investigation represents a versatile strategy for the fabrication of composites for biomedical and other applications, using natural biosurfactants as solubilizing and dispersing agents.
Co-Expression Network and Time-Course Expression Analyses to Identify Silk Protein Regulatory Factors in Bombyx mori

Simple Summary Previous studies have reported how the silk production ability of Bombyx mori can be enhanced, but the mechanism that regulates silk protein genes remains unclear. We performed co-expression network analysis using networkz, an in-house program, which led to the identification of 91 transcription factors were co-expressed with silk protein genes. Of them, 13 transcripts were identified to be novel regulatory factors by time-course expression analysis during the fifth instar larvae stage. Their expression patterns were highly relevant to those of silk protein genes. Our results suggest that the two-step expression screening was robust and highly sensitive to screen relative genes, and a complex mechanism regulates silk protein production in B. mori. The novel candidates that were identified herein can serve as key genes to develop methods to enhance the silk protein production ability of B. mori. Abstract Bombyx mori is an important economic insect and an animal model in pharmacomedical research. Although its physiology has been studied for many years, the mechanism via which silk protein genes are regulated remains unclear. In this study, we performed two-step expression screening, namely co-expression network and time-course expression analyses to screen silk protein regulation factors. A co-expression network analysis using RNA-seq data that were obtained from various tissues, including the silk glands of B. mori, was performed to identify novel silk protein regulatory factors. Overall, 91 transcription factors, including some known ones, were found to be co-expressed with silk protein genes. Furthermore, time-course expression analysis during the fifth instar larvae stage revealed that the expression pattern of 13 novel transcription factors was highly relevant to that of silk protein genes and their known regulatory factor genes. In particular, the expression peak of several transcription factors (TFs) was detected before the expression of silk protein genes peak. These results indicated that a larger number of genes than expected may be involved in silk protein regulation in B. mori. Functional analyses of function-unknown transcription factors should enhance our understanding of this system.
Mapping Risk Judgment and Risk Taking in Mountain Hiking: An Information Integration Approach.

Risk analysis is essential for promoting hiking-based tourism. Our objective in the present study was to map 395 mountain hikers' positions on risk judgment and risk taking, according to how they integrated three antecedent factors of confidence (environment, team, and self). For integrating information, people can develop an additive rule whereby they apply the same weight to all information or use interaction rules (i.e., conjunctive or disjunctive), to give different weights to information. In the questionnaire our participants completed, there were eight scenarios that combined the three confidence antecedent factors as information cues. We applied cluster analysis, repeated-measures analyses of variance, chi-square tests, and bivariate correlation analyses to the questionnaire results to identify three participant risk positions. In the first risk position (cluster 1), participants used a disjunctive integration rule for both risk judgment and risk taking. In the second risk position (Clusters 2 and 4), they used an additive integration rule for risk judgment while they used a disjunctive integration rule for risk taking. In the third risk position (cluster 3), they used an additive integration rule for both risk judgment and risk taking. In each risk position, confidence in the three antecedent factors (environment, team, and self) negatively affected risk judgment and positively affected risk taking. We found the compositions of the clusters to be related to the participants' sex, and we discuss various advantages of applying information integration for mountain hiking practitioners and promoters.
Condensate Formation by Metabolic Enzymes in Saccharomyces cerevisiae

Condensate formation by a group of metabolic enzymes in the cell is an efficient way of regulating cell metabolism through the formation of “membrane-less organelles. ” Because of the use of green fluorescent protein (GFP) for investigating protein localization, various enzymes were found to form condensates or filaments in living Saccharomyces cerevisiae, mammalian cells, and in other organisms, thereby regulating cell metabolism in the certain status of the cells. Among different environmental stresses, hypoxia triggers the spatial reorganization of many proteins, including more than 20 metabolic enzymes, to form numerous condensates, including “Glycolytic body (G-body)” and “Purinosome. ” These individual condensates are collectively named “Metabolic Enzymes Transiently Assembling (META) body”. This review overviews condensate or filament formation by metabolic enzymes in S. cerevisiae, focusing on the META body, and recent reports in elucidating regulatory machinery of META body formation.