Miracle-dz/UniFAR-FTUs huggingface dataset:
Biliary Excretion Index Below Limit of Quantitation BSEP Bile Salt Export Pump CDCA Chenodeoxycholic Acid GCA Glycocholic Acid GCDCA Glycochenodeoxycholic Acid

Author Affiliations: UNC Eshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 (L.M.G., P.B.W., K.L.R.B.); HamnerUniversity of North Carolina, Institute for Drug Safety Sciences, Research Triangle Park, North Carolina 27709 (P.B.W.); Qualyst, Inc., Durham, North Carolina 27713 (K.L.R.B., C.H.P., R.L.S.) DMD Fast Forward. Published on October 22, 2012 as doi:10.1124/dmd.112. 047225
Serum Copeptin - A Diagnostic marker of Acute Myocardial Infarction

The Present study aim is to measure the level of Copeptin in serum of acute myocardial infarction patients and to correlate it with serum CK-MB level. S. Copeptin and S.CK-MB level was estimated in 60 cases of AMI and 60 controls. Mean ± SD of S. Copeptin in Cases and control were (70.2 ± 36.4) and (40.1 ± 15.2). Mean ± SD of S.CK-MB in cases and control were (22.0 ± 9.7) and (8.6 ± 2.8). S. Copeptin and S.CK-MB levels were significantly increased in cases compared to controls. Pearson’s correlation between S. Copeptin and S.CK-MB found to be statistically significant (P<0.0001). Hence estimation of S. Copeptin can be used as diagnostic marker of AMI.
Single-Chain Antibody Fragment Speciﬁc for Plasmodium vivax Duffy Binding Protein (cid:1)

Phage display of single-chain variable fragment (scFv) antibodies is a powerful tool for selecting important, useful, and speciﬁc human antibodies. We constructed a library from three patients infected with Plasmodium vivax . Panning on recombinant PvRII enriched a population of scFvs that recognized region II of the P . vivax Duffy binding protein (DBP). Three clones of scFvs that reacted with PvRII were selected, and their biological functions were analyzed. These scFvs inhibited erythrocyte binding to DBP. Clone SFDBII92 had the greatest afﬁnity (dissociation constant (cid:1) 3.62 (cid:2) 10 (cid:3) 8 M) and the greatest inhibition activity (50% inhibitory concentration (cid:2) 2.9 (cid:4) g/ml) to DBP. Thus, we demonstrated that human neutralizing antibody could be made from malaria patients using phage display and that these neutral- izing scFvs should prove valuable for developing both passive and active immunization strategies based on
Proteinsof Src Homology 2 Domain-Containing Phosphorylation of Cbl and Its Recruitment Protein Kinase C Activation Inhibits Tyrosine

One of the major proteins that is rapidly tyrosine phosphorylated upon stimulation of the TCR/CD3 complex is the 120-kDa product of the c- cbl protooncogene (Cbl). Upon activation, tyrosine-phosphorylated Cbl interacts with the Src homology 2 (SH2) domains of several signaling proteins, e.g., phosphatidylinositol 3-kinase (PI3-K) and CrkL. In the present study, we report that pretreatment of Jurkat T cells with PMA reduced the anti-CD3-induced tyrosine phosphorylation of Cbl and, consequently, its activation-dependent association with PI3-K and CrkL. A speciﬁc protein kinase C (PKC) inhibitor (GF-109203X) reversed the effect of PMA on tyrosine phosphorylation of Cbl and restored the activation-dependent association of Cbl with PI3-K and CrkL. We also provide evidence that PKC a and PKC u can physically associate with Cbl and are able to phosphorylate it in vitro and in vivo. Furthermore, a serine-rich motif at the C terminus of Cbl, which is critical for PMA-induced 14-3-3 binding, is also phosphorylated by PKC a and PKC u in vitro. These results suggest that, by regulating tyrosine and serine phosphorylation of Cbl, PKC is able to control the association of Cbl with signaling intermediates, such as SH2 domain-containing proteins and 14-3-3 proteins, which may consequently result in the modulation of its function. The Journal of Immunology, 1999, 162: 7095–7101.
APPRAISAL OF ULTRA HIGH PERFORMANCE FIBRE REINFORCED CONCRETE FOR POSSIBLE DEVELOPMENT OF INDIGENOUS MATERIALS

iii TABLE OF CONTENTS . iv LIST OF TABLES . vii LIST OF FIGURES . viii CHAPTER ONE: INTRODUCTION . 1 1.1 Background to the Study . 1 1.2 Problem Statement . 3 1.3 Aim and Objectives of the study . 4 1.4 Justification of the Study . 4 1.5 Scope and Limitation of the Study . 4 1.6 Methodology . 4 CHAPTER TWO: LITERATURE REVIEW . 5 2.1 Constituent Materials of Ultra High Performance Fibre Reinforced Concrete . 7 2.2 Mix Proportions of Ultra High Performance Fibre Reinforced Concrete . 9 2.3 Flexural Characteristics of Ultra High Performance Fibre Reinforced Concrete . 9 2.4 Crack Mitigation Ability of Ultra High Performance Fibre Reinforced Concrete . 11
MYOCARDIAL INFARCTION Long-Term Anti-Ischemic Effects of Angiotensin-Converting Enzyme Inhibition in Patients After Myocardial Infarction

Objectives. This study was conducted to test the hypothesis that angiotensin-converting enzyme (ACE) inhibition reduces myocardial ischemia and related events after myocardial infarction (MI). Background. The is inﬂuenced angiotensin II as a result of its arterial vasoconstrictive and inotropic effects and through its interaction with the sympathetic nervous system. ischemia-related events occurred in the captopril group (82 vs. 52, p (cid:53) 0.015). This difference was found between 3 and 12 months but not during the ﬁrst 3 months. After withdrawal from double-blind medication, nine ischemic events were reported in the captopril group compared with one in the placebo group (p (cid:53) 0.006 between groups). Conclusions. The present data show that captopril may reduce the incidence of ischemia-related events after MI, which becomes apparent after 3 months. However, no anti-ischemic effect was observed during exercise testing. After withdrawal from ACE inhibition, a high incidence of clinical events occurred, suggesting a rebound phenomenon.
Oligoclonal bands as predictors of multiple sclerosis inclinically isolated syndrome

Clinically Isolated Syndrome (CIS) is the first episode of inflammatory and demyelinating symptoms. According to the classification criteria of multiple sclerosis (MS) from 2013, CIS is defined as the first clinical manifestation of the disease. McDonald's 2010 criteria, considered the gold standard in the diagnosis of MS, are based on the clinical symptoms and the characteristic changes in magnetic resonance imaging (MRI). Unfortunately, up to 60-70% of patients with CIS do not meet the criteria for diagnosing MS at an early stage. At the same time, approximately 85% of patients with CIS will develop clinically defined MS(CDMS) in the future. When looking for other diagnostic tools, attention was paid to the role of oligoclonal bands (OBs) as predictors of MS development. Oligoclonal bands are immunoglobulins produced intrathecally by B-lymphocytes and plasma cells. Their level is examined in cerebrospinal fluid (CSF) collected by lumbar puncture. Studies carried out on a group of patients with CIS showed that people with positive testresultsfor oligoclonal bands are twice as likely to develop MS than people with negative OBs. These conclusions are reflected in the revised McDonald's criteria in 2017, where OBs are used in the diagnosis of CIS patients with absence of new symptoms of the disease and changes in MRI.Early diagnosis makes possible to implement modifying disease drugs in the initial stage and, consequently, to achieve better therapeutic effects. The emphasis is also put on the development of other predictors in body fluids, which are effective in the diagnosis of people with CIS and negative oligoclonal bands. Many factors, including Epstein-Barr virus, chitinase-3 like 1, chitinase-3 like 2, chitotriosidase, multi-specific response to measles, rubella and varicella known as "MRZ reaction" orT-cell gene mutation are studied as a potential risk factors for MS development. Their use in diagnostics would improve the detection of MS in earlier stages, and thus the treatment of largerpopulation of patients.
Denial and Negative Policing of Same-Sex Intimacy and Existence

Denial of Sexual Diversity Framing of same-sex intimacy as a perversion that flies in the face of religious morality still features prominently within contemporary homophobic discourse which reinforces the fear and prejudice that encourages homophobia and the victimisation of (Muholi, Zanele, 2009) homophobia is not only publicly approved by society, but relies on unsubstantiated claims of a superficial and
Cellulose Nanocrystals from native and 1 mercerized cotton 2

: Nanocelluloses occur under various crystalline forms that are being selectively used for 11 a wide variety of high performance materials. In the present work, cellulose fibers (CF-I) were 12 mercerized by alkaline treatment (CF-II) without molar mass variation (560 000 g/mol) and both 13 were acid hydrolyzed, forming cellulose nanocrystals in native (CNC-I) and mercerized (CNC-II) 14 forms. This work establishes detailed characterization of these two nanoparticles morphology 15 (light and neutron scattering, TEM, AFM), surface chemistry (zetametry and surface charge), 16 crystallinity (XRD, 13 C NMR), and average molar mass coupled to chromatographic technics (SEC- 17 MALLS-RI, A4F-MALLS-RI), evidencing variations in packing of the crystalline domains. The crystal 18 size of CNC-II is reduced by half compared to CNC-I, with molar masses of individual chains of 41 19 000 g/mol and 22 000 g/mol for CNC-I and CNC-II respectively, whereas the same charged surface 20 chemistry is measured. This fundamental analysis may give insight to new applicative 21 development. biobased nanoparticles,
Noise analysis of replica driving technique and its verification to 12-bit 200(cid:3027)MS/s

: This study demonstrates the noise analysis of a replica driving MDAC architecture, which is verified by implementing a 12-bit 200 MS/s replica driving pipelined analogue-to-digital converter (ADC). Based on the noise design strategy with the target effective number of bits = 10.5-bit, the overall dynamic performance degradation by KT/C noise and thermal noise by an amplifier is alleviated by removing the front-end sample-and-hold (S/H) circuit, and the transconductance ( g m ) of the inner source follower is maximised by increasing the current and threshold voltage ( V T ) reduction. Replica input sampling networks are designed for the first-stage sub-ADC and the first-stage MDAC with different aspect ratios to minimise the sampling skew for the S/H-less architecture. A prototype 12-bit 200 MS/s ADC is fabricated in a 65 nm complementary metal oxide semiconductor. The measured spurious-free dynamic range (SFDR) and signal-to-noise distortion ratio (SNDR) at a 1.0 MHz input signal is 82.6 and 65.6 dB, respectively, and SFDR and SNDR at the Nyquist (=99.0 MHz) input are 77.3 and 58.6 dB, respectively. The ADC core and the reference driver consume 53.9 and 13.2 mW, respectively, at a 1.2 V supply voltage.
Research Online Research Elucidating the surface geometric design of hydrophobic Elucidating the surface geometric design of hydrophobic Australian Eucalyptus leaves: experimental and modeling studies Australian Eucalyptus leaves: experimental and modeling studies

Three Australian native Eucalyptus species, i.e., Eucalyptus woodwardii , Eucalyptus pachyphylla and Eucalyptus dolorosa , were investigated, for the ﬁ rst time, with respect to the hydrophobicity of their leaves. It is well established that these leaves exhibit exceptionally high water repellency, in addition to an extraordinary ability to retain water, albeit their speci ﬁ c wetting mechanisms are still poorly understood. To identify the critical factors underlying this phenomenon, the surface topography of these leaves was subjected to micro-Received: examination (SEM). Micro- and nanometer scale surface roughness was revealed, resembling that of the quintessential “ lotus e ﬀ ect ” . Surface free energy analysis was performed on two models based on the surface topographies of the study Eucalyptus species and lotus, in order to study wetting transitions on these speci ﬁ c microscopic surface features. The in ﬂ uence of surface geometrical parameters, such as edge-to-edge distance, base radius and cylindrical height, on surface free energy with di ﬀ erent liquid penetration depths was studied with these two models. Larger energy barriers and smaller liquid-solid contact areas were more in ﬂ uential in the calculations for the lotus than for Eucalyptus . The information obtained from these two models may be useful for guiding the design of novel arti ﬁ cial surfaces in the collection and transport of micro-volume liquids.
Predicting the next page that will be visited by a web surfer using Page Rank algorithm

— Predicting the next page to be visited by a web user with increasing accuracy have many important applications like caching and prefetching web pages to improve the speed of navigation or creating systems of recommendation to help users to find faster in the site what they are looking for. We have created a java program, using Net Beans IDE, that calculates the probability of visiting the pages using the page rank algorithm and counting links. For exemplification we used the NASA log file available online at http://ita.ee. lbl.gov/html/contrib/NASA-HTTP.html and a log file from a commercial web site http://www.nice-layouts.com . We applied to the entire data set of sessions the program and we obtained probabilities of visiting the pages. After that we applied the program only to the subset of sessions which contain the current page. For data obtained from log files of the NASA website was obtained an improvement in prediction in the sense of increasing the precentage from 19,75% to 32,5%. In the case of data obtained from the log files of the commercial site the improvements for the predictions was smaller from 74,66% to 77,77%. In the chapter with conclusions we present explanations for this differences of improvments obtained in those two cases.
Semiactive Hybrid Energy Management System: A Solution for Electric Wheelchairs

Many disabled people use electric wheelchairs (EWs) in their daily lives. EWs take a considerable amount of time to charge and are less efficient in high-power-demand situations. This paper addresses these two problems using a semiactive hybrid energy storage system (SA-HESS) with a smart energy management system (SEMS). The SA-HESS contained a lithium-ion battery (LIB) and supercapacitor (SC) connected to a DC bus via a bidirectional DC–DC converter. The first task of the proposed SEMS was to charge the SA-HESS rapidly using a fuzzy-logic-controlled charging system. The second task was to reduce the stress of the LIB. The proposed SEMS divided the discharging operation into starting-, normal-, medium-, and high-power currents. The LIB was used in normal conditions, while the SC was mostly utilized during medium-power conditions, such as starting and uphill climbing of the EW. The conjunction of LIB and SC was employed to meet the high-power demand for smooth and reliable operation. A prototype was designed to validate the proposed methodology, and a comparison of the passive hybrid energy management system (P-HESS) and SA-HESS was performed under different driving tracks and loading conditions. The experimental results showed that the proposed system required less charging time and effectively utilized the power of the SC compared with P-HESS.
Characteristics of the boundary layer of magnetic clouds and a new definition of the cloud boundary

Based on the analysis of the boundaries of 70 magnetic clouds from 1967 to 1998, and relatively complete spacercraft observations, it is indicated that the magnetic cloud boundaries are boundary layers formed through the interaction between the magnetic clouds and the ambient medium. Most of the outer boundaries of the layers, with relatively high proton temperature, density and plasma β, are magnetic reconnection boundaries, while the inner boundaries, with low proton temperature, proton density and plasma β, separate the main body of magnetic clouds, which has not been affected by the interaction, from the boundary layers. The average time scale of the front boundary layer is 1.7 h and that of the tail boundary layer 3.1 h. It is also found that the magnetic probability distribution function undergoes significant changes across the boundary layers. This new definition, supported by the preliminary numerical simulation in principle, could qualitatively explain the observations of interplanetary magnetic clouds, and could help resolve the controversy in identifying the boundaries of magnetic clouds. Our concept of the boundary layer may provide some understanding of what underlies the observations, and a fresh train of thought in the interplanetary dynamics research.
Hardness of Approximating Minimization Problems

We show that a number of natural optimization problems in the second level of the Polynomial Hierarchy are \math hard to approximate to within \math factors, for specific \math. The main technical tool is the use of explicit dispersers to achieve strong, direct inapproximability results. The problems we consider include Succinct Set Cover, Minimum Equivalent DNF, and other problems relating to DNF minimization. Under a slightly stronger complexity assumption, our method gives optimal \math inapproximability results for some of these problems. We also prove inapproximability of a variant of an NP optimization problem, Monotone Minimum Satisfying Assignment, to within an \math factor using the same technique.
Is Fear of Movement (FoM) in sports related activities a latent trait?: the item response model applied to the Photographic Series of Sports Activities for Anterior Cruciate Ligament Rupture (PHOSA-ACLR). CURRENT STATUS: UNDER REVIEW

Background. Fear of Movement is an important factor predicting return to sports in Anterior Cruciate Ligament Reconstruction (ACLR). Fear for specific ACLR related movements can be addressed measuring the Photographic Sports Activities for ACLR (PHOSA-ACLR). This study was conducted to determine whether Fear of Movement assessed using the PHOSA-ACLR is a latent trait, and to analyse differences in PHOSA-ACLR in athletes with or without an ACL rupture. Methods. Data from three groups of participants were included in this study: 1) ACLR patients participated in a previous study measuring psychological dimensions after ACLR (n = 58); 2) first year physical therapy students at the HAN University of Applied Sciences (n = 169), and 3) junior football players that were enrolled in a training programme of the Professional Soccer club Vitesse (Arnhem) (n = 30). All participants completed the PHOSA-ACLR (scale score 0-10), and questions related to demographics. ACLR patients completed additional questionnaires to assess functioning and Fear of Harm. PHOSA-ACLR items were analysed with Item Response Theory using the Graded Response Model (GRM). Differences between three groups of participants were analysed using Univariate Analysis of Variance. to expectations, PHOSA-ACLR is higher in first year physiotherapy students compared to patients rehabilitating from ACLR, and healthy junior soccer players. The PHOSA-ACLR might be useful for clinicians to identify high levels of fear of movement related to ACLR, and provide a tool to help the patient overcome fear of movement using exposure techniques.
Content-based Pipeline Model for Multicore Web Server

: Web servers frequently in high traffic need proper mechanisms to ensure the quality of service. Current operating systems and network protocols haven't make effective use of multicore to take full advantage of parallel computing. By improving the mechanism of web servers, adopting stage event-driven architecture and the idea of vector operating system, this research proposed a new handling model of web servers in the case of making responses for a mass of concurrent and high duplicated requests, which aims at reducing average response time, increasing throughout and as well improving the performance of web servers.
Bioaccumulation Factor (BAF) of Heavy Metals in Selected Grassy Species in Mejia Thermal Power Plant, West Bengal, India

Pollution from fly ash is one of the principle environmental and public health problems in recent times. Concentrations of toxic metals of Zn, Cu, Pb were determined in the grassy vegetation around Mejia Thermal Power Station, West Bengal, India during November, 2015. Simultaneously the biologically available heavy metals in the fly ash were also estimated to evaluate the bioaccumulation factor (BAF) in the selected grass species. The study reveals that BAF is more in Typha elephantia as compared to Phargmites karka . The present study is a probable road map for natural bioremediation of fly ash using producer community of the area.
Electrochemical Performance of Nano-fibrous Selenium Cathode Synthesized by Reverse Solvent Method for Rechargeable Li-batteries

: Nano-fibrous selenium of high purity and crystallinity with a diameter of 100 nm were synthesized by the reverse solvent method. The structure and morphology of products were characterized by X-ray diffraction and scan-ning electron microscope, respectively. Since the size of elemental selenium is reduced, the inactivaton effect induced by the coverage of fully insulated discharge product Li 2 Se on Se particles surface is mitigated, thus greatly improving the utilization coefficient of active materials and alleviating the capacity fading of lithium-selenium batteries. Com-pared with the pristine selenium cathode, Se fiber electrode presents higher specific capacity and better cycling stabil-ity which delivers an initial specific discharge capacity of 465 mAh/g at 0.1 C (1 C =675 mAh/g) and maintains a capacity of 213 mAh/g after 40 cycles. Meanwhile, Se fiber electrode shows higher electrochemical activity than pristine Se electrode due to its shorter lithium ion diffusion path, resulting in a substantially enhanced rate capability of Se fiber electrode.
ArticleMechanical Properties of Polymer Coatings Applied to Fabric Serhiy Horiashchenko1

The polymer film, formed on fabric, has a diverse resistance to impact (shear) forces during deformation. An original model of the capillary-porous structure of the fabric, partially filled with polymer, was presented and discussed in this paper. Polymer material fixing relations were developed, taking into account the fabric structure and changes of polymer temperature. Experimental studies were performed on three different materials: artificial leather SK-2, GOST 16119-70 (230 g/m2); genuine beef skin, GOST 939-75 (2.2 g/m3); and fabric denim, GOST 29298-2005 (225 g/m2). The value of mathematical model analysis deviation compared with the experimental value was approximately 12%. The obtained mathematical dependences were the basis for predicting the increase of the dimensional stability of garments by applying hot melt polymer to its surface. It is also possible to design new equipment for its implementation.