Miracle-dz/UniFAR-FTUs huggingface dataset:
VU Modulation of inflammation and cytokine production by dietary (n- 3) fatty acids

The production of pro-inflammatory cytokines, such as interleukin-1 and tumor necrosis fac tor, is pivotal in the response to infection. However, overproduction of these cytokines might be detrimen tal. It has been suggested that (n-3) fatty acids sup press inflammation and ameliorate the course of infec tion by decreasing the production of pro-inflammatory cytokines. We here, review these effects, use of (n-3) fatty acids induced moderate clinical improvements in rheumatoid arthritis, psoriasis and colitis, but not in systemic lupus erythematosus. Data on critically ill burn or postoperative cancer patients are still inconclu sive. The (n-3) fatty acids markedly inhibited sterile inflammation in animal studies and improved survival in some experimental infections. T cell responses de creased in healthy volunteers but remained unchanged or increased in certain patient groups. The production of pro-inflammatory cytokines decreased in most hu man studies. The (n-3) fatty acids increased cytokine production capacity in mice. Differences in cytokine-producing cell types studied may account for these paradoxical responses in humans and mice. Although the increased cytokine production in mice is partly me diated by effects on prostaglandins, mechanisms of action in other species remain to be elucidated. The (n-3) fatty acids may be of moderate benefit in some chronic inflammatory diseases. Their therapeutic value and possible hazards in critically ill patients remain to be established. J. Nutr. 126: 1515-1533, 1996.
Research on the Impact of Technology Innovation on Quantity and Quality of Economic Growth in the Yangtze River Delta of China: A Comparative Study

High-quality economic development (HQED) has recently become a crucial sustainable growth mode in China, which pursues economic growth while maintaining social equity and green ecology. The HQED of the Yangtze River Delta (YRD) has played an exemplary role in achieving the leap from “China speed” to “China Quality”. In this paper, we first use the entropy-weight multidimensional comprehensive evaluation method to calculate the HQED index as a proxy for the quality of economic growth. Then, using panel data of 41 cities in the YRD, we conduct a comparative study to examine impacts of technological innovation (TI) on quantity and quality of economic growth by employing different panel estimation models over the period 2009-2019 and check the robustness in five ways. Finally, this paper investigates the TI-economic growth link based on the panel quantile regression across the conditional distributions of economic growth levels. Results show that TI has significantly positive effects in terms of both quantity and quality of economic growth, and the promoting effect on the quantity of economic growth is almost four times higher than that of quality under mean estimations by double fixed-effects. The effect on quantity of economic growth is also stronger than that of quality under the conditional distribution, and TI has a stronger impact for regions with higher levels of economic growth.
5-Hydroxymethylfurfural Oxidation Over Platinum Supported on Açaí Seed Coal for Synthesis of 2,5-Furandicarboxylic Acid

2,5-furandicarboxylic acid (FDCA) is produced from the selective oxidation of 5-hydroxymethylfurfural (HMF) and is an important platform molecule applied in the pharmaceutical and petrochemical industries. Activated carbons produced from renewable resources are useful materials due to their physicochemical properties, defined mainly by the oxygenated functional groups on their surface. This work studies the oxidation of HMF to FDCA over Pt catalysts supported on açaí coal. The catalysts were characterized by N2 adsorption, XPS, ToF-SIMS, FTIR, XRD, Raman, TEM, SEM, TPR-H2, and TGA/DTA. The conversion of HMF to FDCA in an alkaline medium occurred via hydroxymethyl-2-furancarboxylic acid (HMFCA), which was oxidized to 5-formylfurancarboxylic acid (FFCA) and FDCA. The catalytic tests showed a high conversion of HMF with a 93.6% yield of FDCA. The excellent results were attributed to the high dispersion of Pt on the support and the presence of oxygenated functional groups on the coal surface. The functional groups increased the interaction between Pt-HMF and Pt-furan intermediates and favored a higher dispersion of platinum (53.3%) due to an anchoring effect.
Optimization and characterization of functional chocolate with addition of butter fruit milkshake powder as a source of phenolic, flavonoid and carotenoid

: Butter fruit milkshake powder (BFMS) is a healthful mixture of avocado pulp and dairy components with high nutritional and antioxidant activity. In this study, an attempt has been made to enhance the nutraceutical and functional properties of the chocolate with BFMS powder at the 15-60% level based on the physical, nutritional, sensory attributes, and storage of study. Sensory studies of chocolate indicated that maximum sensory score was found at 30% incorporation of BFMS without adverse effects. BFMS powder’s addition increased the contents of fat, dietary fibers, proteins, phenolic, flavonoid, and beta carotenoid content of chocolate. Mineral element (Ca, Mg, Fe, Zn, and Mn) were also increased with the addition of BFMS in chocolate. Storage studies of BFMS powder fortification in chocolate revealed that butter fruit milkshake chocolate (BFMSC) significantly more stable than control chocolate and accepted by consumers up to 60 days of storage. This study showed that BFMS powder fortified chocolate was nutritionally improved and economical with acceptable sensory properties. This may increase the market’s revenue and enable chocolate companies to develop a functional new chocolate type.
Determination of Heavy Metals in Selected Meat and Meat Products from Meat Market of Singrauli

The presence of heavy metals such as cadmium and chromium in meat and meat product may cause harm to people since they are part of their everyday diet. In this study, (09) nine different meat sample (Composed of raw, ground and processed) were taken and measured quantitatively with the help of flameless atomic absorption spectrophotometer. In this study it was found that the cadmium content is within the limit while chromium content also found within the limit. But there is no standard limit set by the United States environmental protection agency, in case of chromium content. Keyword: Meat, meat product, raw meat, ground meat, processed meat, heavy metals toxicants.
SCOTER - Multiple-Earthquake Location by Using Static and Source-Specific Station COrrection TERms

There has been growing recognition of the importance of the accurate seismic locations in quantitative seismological studies, such as seismic hazard analyses, fault zone characterization, and Earth’s deformation. Accurate estimation of seismic locations is critical since a wrong estimate of the seismic source location will result in wrong interpretations in the subsequent analyses. We present SCOTER, an open-source Python program package that is designed to relocate multiple seismic events by using P and S -wave station correction terms. The package implements static and shrinking-box source-specific station terms techniques extended to regional and teleseimic distances and adopted for probabilistic, non-linear, global-search location for large-scale multiple-event location. This program provides robust relocation results for seismic event sequences over a wide range of spatial and temporal scales by applying empirical corrections for the biasing effects of 3-D velocity structure. Written in the Python programming language, SCOTER is run as a stand-alone command-line tool (requiring no knowledge of Python) and also provides a set of sub-commands to develop inputs (dataset, configuration etc) and export results (hypocenter parameters, travel-time residuals etc) – routine but non-trivial tasks that can consume much user time. This package can be used for relocation in local, regional, and teleseimic scales. We describe SCOTER’s functionality, design and technical implementation, accompanied by an overview of its use cases. As an illustration, we demonstrate the applicability of this tool through two examples based on (1) a catalogue of several hundred events in the Arctic plate boundary region using regional and teleseismic arrival times and (2) a small dataset of low-magnitude seismic events recorded by dense, local stations at the western Iberia, central Portugal. The relocated datasets highlight the future potential for applying the SCOTER relocation tool to greatly improve the relative location accuracy among nearby events.
Beyond Broca: neural architecture and evolution of a dual motor speech coordination system.

Classical neural architecture models of speech production propose a single system centered on Broca's area coordinating all the vocal articulators from lips to larynx. Modern evidence has challenged both the idea that Broca's area is involved in motor speech coordination and that there is only one coordination network. Drawing on a wide range of evidence, here we propose a dual speech coordination model in which laryngeal control of pitch-related aspects of prosody and song are coordinated by a hierarchically organized dorsolateral system while supralaryngeal articulation at the phonetic/syllabic level is coordinated by a more ventral system posterior to Broca's area. We argue further that these two speech production subsystems have distinguishable evolutionary histories and discuss the implications for models of language evolution.
Diversity of dermal fibroblasts as major determinant of variability in cell reprogramming

Induced pluripotent stem cells (iPSCs) are adult somatic cells genetically reprogrammed to an embryonic stem cell‐like state. Notwithstanding their autologous origin and their potential to differentiate towards cells of all three germ layers, iPSC reprogramming is still affected by low efficiency. As dermal fibroblast is the most used human cell for reprogramming, we hypothesize that the variability in reprogramming is, at least partially, because of the skin fibroblasts used. Human dermal fibroblasts harvested from five different anatomical sites (neck, breast, arm, abdomen and thigh) were cultured and their morphology, proliferation, apoptotic rate, ability to migrate, expression of mesenchymal or epithelial markers, differentiation potential and production of growth factors were evaluated in vitro. Additionally, gene expression analysis was performed by real‐time PCR including genes typically expressed by mesenchymal cells. Finally, fibroblasts isolated from different anatomic sites were reprogrammed to iPSCs by integration‐free method. Intriguingly, while the morphology of fibroblasts derived from different anatomic sites differed only slightly, other features, known to affect cell reprogramming, varied greatly and in accordance with anatomic site of origin. Accordingly, difference also emerged in fibroblasts readiness to respond to reprogramming and ability to form colonies. Therefore, as fibroblasts derived from different anatomic sites preserve positional memory, it is of great importance to accurately evaluate and select dermal fibroblast population prior to induce reprogramming.
DSCA: an inline and adaptive application identification approach in encrypted network traffic

Adaptive application detection in today's high-bandwidth networks is resource consuming and inaccurate due to the high volume, velocity, and variety characteristics of the networks traffic. To generate a robust classifier for identifying applications over encrypted traffic, we proposed DSCA as a DPI-based Stream Classification Algorithm. DSCA utilizes applications detected by the DPI, Deep Packet Inspection technique, as ground truth data and updates the classification model accordingly. To reduce the classification algorithms overhead without accuracy reduction, a feature selection method, named CfsSubsetEval, is deployed in DSCA. The proposed approach is implemented via the MOA tool and the performance is evaluated through UNB ISCX VPN-nonVPN and UNB ISCX Tor-nonTor datasets. 10 different stream and traditional classification algorithms are integrated with DSCA. The simulation results represent DSCA with Adaptive Random Forest stream classification algorithm has the best performance over UNB ISCX VPN-nonVPN which processed the dataset in 8.63 seconds with 96.75% accuracy. About UNB ISCX Tor-nonTor dataset, DSCA and Knn with PAW classification algorithm have the best performance (86.92% accuracy and 12.05 seconds execution time).
Dress me up!: content-based clothing image retrieval

It is sometimes difficult for a person to find a matching outfit in a clothing store. It would be beneficial if there is a mechanism which allows a person to provide an example of clothes that they are looking for in the form of an image instead of text description and they will be provided with similar items that the store have. In this paper, we propose a framework for content-based clothing image retrieval that allows searching and retrieving of similar clothes based on colour and shape features. We first convert the RGB image to HSV colour space. Colour histogram is then computed for colour representation while the shape representation is obtained from low and high thresholding computation. The similarity between input image and image collection is computed based on Manhattan distance. The proposed framework can aid users in finding the desired and similar clothing images from catalogues effectively without the needs of text-based input. Users can also search for similar clothing based on specific features like colour or shape. For each clothes, the item's descriptions like brand, size, and price are also being displayed. We have conducted retrieval effectiveness experiment and questionnaire-based survey to measure the effectiveness of our framework and users' acceptance. We have obtained good results for both evaluation approaches.
Nonlinear characteristics of the vegetation change and its response to climate change in the karst region of southwest China

The vegetation is known to be sensitive to both climate change and anthropogenic disturbance. However, the relationship between changes in vegetation and climate is unclear in karst regions. The nonlinear characteristics of vegetation change and its possible relationships with driving factors in the karst region of southwest China are revealed, using methods of Ensemble Empirical Mode Decomposition, Mann-Kendall, and Partial Least Squares Regression. The results show that: (1) vegetation changes demonstrate an increasing trend with an abrupt change in 2002. Multiple time scales of 3, 6, 10, and 25-year are observed in vegetation variations, dominated by long-term trend and the short time scale of 3-year with variance contributions of 58.10% and 28.63%. (2) The relationship of climate indexes with vegetation changes shows r2 = 0.78 (p < 0.01) based on the reconstruction of characteristic scales, indicating significant great relationship. In space, the area percentage with relationship of climate to vegetation is more than 50%, and the impact is much greater after the abrupt change of vegetation in 2002 (r2 are 0.24–0.91 and 0.42–0.99, respectively). In addition, the correlation between vegetation change and ecological engineering is 0.15 (p < 0.01). The results indicate that climate change is the main impact factor of vegetation change, ecological engineering has positive influences in improving vegetation condition, and methods of scales decomposition and abrupt detection could reveal some hidden information for better understanding ecosystems in karst regions.
An Evaluation of the Impact of War on Pregnancy in Syrian Refugee Women: A Retrospective Study

Objective: The aim of this study was to investigate the perinatal and postpartum results of refugee Syrian pregnant women in Turkey and to evaluate the effect of the war on pregnancy. Material and Methods: In the study, a total of 1020 women applying for pregnancy and giving birth at Bakırkoy Dr. Sadi Konuk Training and Research Hospital, Department of Gynecology and Obstetrics Clinic between the 2014 January-2016 January dates were included, 509 of whom were Syrian refugees and 511 of whom were Turkish. By examining the files belonging to the patients retrospectively, the number of gravida, parity, birth and abortus were determined; normal, vaginal birth and caesarean section as a delivery method were recorded separately. Parameters for the birth and infants were determined individually. Results: When the demographic information of the patients included in the study were evaluated, it was found that the age of Syrian women was significantly lower than those of Turkish women. (p ˂ 0.05). In addition, the gestational week in Syrian women was significantly lower than those of Turkish women (p ˂ 0.05). When the birth weight of both groups was compared, the birth weight of the Syrian women was significantly lower than those of Turkish women (p ˂ 0.05). Another parameter assessed during our study is the delivery method: The cesarean delivery rate of the Syrian women was determined significantly lower than those of Turkish women (p ˂ 0.05). No significant difference was observed between the two groups in the other parameters evaluated (p> 0,05). Conclusion: In order to improve the antenatal care of the Syrian immigrant women; we are on the opinion that it is necessary to create ideal solutions by working with international organizations about communication and language.
Evaluation of the Implementation of the Advance Care Planning Package in South Western Sydney

Aims and Objectives: To develop an understanding of the implementation of the Community-Criteria for Screening and Triaging to Appropriate aLternative care (C-CriSTAL) initiative in primary healthcare setting in South Western Sydney (SWS). Background: C-CriSTAL is a prognostic assessment tool that identifies elderly patients at the end-of-life (EOL), quantifies the risk of imminent death and facilitates discussion on care preferences. A General Practice co-designed initiative C-CriSTAL was developed which included an advance care planning implementation package (ACPIP) with the components of early detection, identification of EOL care needs and communication with the patient in primary healthcare setting. Design: Qualitative study. Methods: Semi-structured interviews were conducted with purposive sample of Execu-tive Sponsor and members of the Clinical Reference Group including representatives from a Local Health District, C-CriSTAL Project Team, a Primary Health Network, Consumer, General Practitioners. The Interviews were recorded, transcribed verbatim and analysed qualitatively by means of a thematic analysis. Results: A total of 12 interviews were conducted. Thematic analysis resulted in identification of three salient themes: 1) Success accepted and perceived as valuable and beneficial for patient’s health care. The tool enhanced clinician’s confidence in initiating earlier EOL discussions and empowered patients to express EOL wishes in a comfortable environment then subsequently documented in the form of an advance care directive (ACD). However, challenges to sustain the program as a whole in the longer term were evident due to issues of time, funding, education/training for staff. Relevance to Clinical Practice: This study provides insight into the practical considerations as well as barriers and facilitators to the implementation of C-CriSTAL package in primary healthcare setting.
Retinoids induce antagonism between FOXO3A and FOXM1 transcription factors in human oral squamous cell carcinoma (OSCC) cells

To gain a greater understanding of oral squamous cell carcinoma (OSCC) we investigated the actions of all-trans-retinoic acid (RA; a retinoid), bexarotene (a pan-RXR agonist), and forkhead box (FOX) transcription factors in human OSCC-derived cell lines. RA and bexarotene have been shown to limit several oncogenic pathways in many cell types. FOXO proteins typically are associated with tumor suppressive activities, whereas FOXM1 acts as an oncogene when overexpressed in several cancers. RA and/or bexarotene increased the transcript levels of FOXO1, FOXO3A, and TRAIL receptors; reduced the transcript levels of FOXM1, Aurora kinase B (AURKB), and vascular endothelial growth factor A (VEGFA); and decreased the proliferation of OSCC-derived cell lines. Also, RA and/or bexarotene influenced the recruitment of FOXO3A and FOXM1 to target genes. Additionally, FOXM1 depletion reduced cell proliferation, decreased transcript levels of downstream targets of FOXM1, and increased transcript levels of TRAIL receptors. Overexpression of FOXO3A decreased proliferation and increased binding of histone deacetylases (HDACs) 1 and 2 at the FOXM1, AURKB, and VEGFA promoters. This research suggests novel influences of the drugs RA and bexarotene on the expression of FOXM1 and FOXO3A in transcriptional regulatory pathways of human OSCC.
Dereplication of Components Coupled with HPLC-qTOF-MS in the Active Fraction of Humulus japonicus and It’s Protective Effects against Parkinson’s Disease Mouse Model

Humulus japonicus is an annual plant belonging to the Cannabacea family, and it has been traditionally used to treat pulmonary tuberculosis, dysentery, chronic colitis, and hypertension. We investigated the active components against Parkinson’s disease from H. japonicus fraction (HJF) using high performance liquid chromatography (HPLC) coupled with quadruple-time-of-flight mass spectroscopy (qTOF-MS) and NMR. Fourteen compounds were isolated from HJF, including one new compound, using HPLC-qTOF-MS and NMR. The major compounds of HJF were luteolin-7-O-glucoside and apigenin-7-O-glucoside, and there was approximately 12.57- and 9.68-folds increase in the contents of these flavonoids compared to those of the 70% EtOH extract. Apigenin and luteolin exhibited the strongest inhibitory effects on monoamine oxidase (MAO) B enzyme activity. In animal studies, limb-use behavior was significantly reduced by unilateral 6-OHDA lesion and ipsilateral rotations. These results indicated that oral administration of 300 mg/kg HJF resulted in the improvement of motor asymmetry and motor impairment in unilateral 6-OHDA-lesioned mice. HJF, including active components leads to an improvement of motor behavior in a Parkinson’s disease mouse model.
To freeze or not to freeze: A culture-sensitive motion capture approach to detecting deceit

We present a new signal for detecting deception: full body motion. Previous work on detecting deception from body movement has relied either on human judges or on specific gestures (such as fidgeting or gaze aversion) that are coded by humans. While this research has helped to build the foundation of the field, results are often characterized by inconsistent and contradictory findings, with small-stakes lies under lab conditions detected at rates little better than guessing. We examine whether a full body motion capture suit, which records the position, velocity, and orientation of 23 points in the subject’s body, could yield a better signal of deception. Interviewees of South Asian (n = 60) or White British culture (n = 30) were required to either tell the truth or lie about two experienced tasks while being interviewed by somebody from their own (n = 60) or different culture (n = 30). We discovered that full body motion–the sum of joint displacements–was indicative of lying 74.4% of the time. Further analyses indicated that including individual limb data in our full body motion measurements can increase its discriminatory power to 82.2%. Furthermore, movement was guilt- and penitential-related, and occurred independently of anxiety, cognitive load, and cultural background. It appears that full body motion can be an objective nonverbal indicator of deceit, showing that lying does not cause people to freeze.