Miracle-dz/UniFAR-FTUs huggingface dataset:
Overactivation of the Aldosterone/Mineralocorticoid Receptor System in Metabolic Syndrome and its Implication in Cardiac and Kidney Injury

The modern sedentary lifestyle, unhealthy food with too much fat and salt, physical inactivity and psychological stress have led to a global epidemic of obesity in the last few decades (Flier 2004, Mann 2005). A worldwide survey on long-term trends of body-mass index (BMI) Abstract: Aldosterone is traditionally viewed as a hormone regulating the homeostasis of electrolytes, body fl uid volume, and blood pressure. Recently, aldosterone emerged as a deleterious hormone in the cardiovascular and renal system. We examined whether the aldosterone/mineralocorticoid receptor (MR) system is involved in the process leading from metabolic syndrome to kidney disease. We demonstrated that SHR/cp, a rat model of metabolic syndrome, was susceptible to podocyte injury, proteinuria, and chronic kidney disease. Aldosterone excess caused by adipocyte-derived aldosterone releasing factors was suggested to underlie the nephropathy, and MR antagonist ameliorated the injury. High salt reduced plasma aldosterone, but paradoxically augmented MR activation and exacerbated cardiac and renal injury, which was mitigated by MR antagonist. These fi ndings corroborate our hypothesis that obesity and salt, two cardinal features of modern society, cause MR overactivation and cardiorenal diseases. Furthermore, we identifi ed an alternative pathway of MR activation by Rac1 GTPase. RhoGDIα knockout mice, a kidney-specifi c Rac1 activation model, developed albuminuria, podocyte damage, and glomerulosclerosis. The knockout mice exhibited enhanced MR signaling despite normoaldosteronemia, and MR antagonist dramatically abrogated renal impairment. Importantly, Rac-sepcifi c inhibitor substantially ameliorated renal injury, concomitantly with repression of Rac1 and MR activity. In vitro transfection studies provided direct evidence of Rac1-mediated MR activation. The “Rac1-mediated MR activation” was also critically involved in angiotensin II/salt-induced nephropathy, Dahl salt-sensitive hypertension, and oxidative stress-evoked cardiac injury. In conclusion, our fi ndings suggest that MR activation plays a pivotal role in the pathogenesis of chronic kidney disease in metabolic syndrome, and that MR may be activated both aldosterone dependently (via aldosterone releasing factors) and independently (via Rac1). MR antagonists, or agents that modulate MR activity such as Rac inhibitors, are promising renoprotective drugs in metabolic syndrome, although long-term effects on renal outcomes, mortality, and safety need to be established.
Effects of the New Antifungal Thio Halo-Benzene Derivative 5-Bromo-2-Iodo-1,3-Bis(Phenylthio)Benzene Molecule on Rat Liver and Kidney Tissue Oxidative Events

Nowadays, fluconazole is a widely used antifungal drug. Besides its similarities with the carbon structure of fluconazole, the newly synthesized 5-bromo-2-iodo-1,3-bis(phenylthio)benzene is also more active than low concentrated of fluconazole. Oxidative events occur in the organism during the drug metabolism. In this study, effects of previously proved as an antibacterial and antifungal molecule 5-bromo-2-iodo-1,3-bis(phenylthio)benzene investigated (C 18 H 12 S 2 IBr) on mammal liver and kidney tissue using biochemical methods. 80 male and female Wistar albino rats between the ranges of 150-200 gr have been used for this study. Kidney and liver tissues malondialdehyde (MDA), glutathione (GSH), nitric oxide (NO) levels, and myeloperoxidase activities (MPO) studied using spectrophotometric methods. We found that this new compound as a potential alternative to fluconazole did not cause any lipid peroxidation in the liver tissue of female rats and in kidney tissue of male rat. This could be because of hormone (gonadal hormone) or metabolism differences of the sexes. It may be remarkable to note that 5-bromo-2-iodo-1,3-bis(phenylthio) benzene molecule does not cause nitrosative species formation at both doses and sexes. Also 5-bromo-2-iodo-1,3-bis(phenylthio) benzene may increase tissue antioxidant capacity in rats. Both doses of the newly synthesized 5-bromo-2-iodo-1,3-bis(phenylthio) benzene molecule may not cause respiratory burst in the liver and kidney tissues in both sexes.
CURRENT AND FUTURE HABITAT SUITABILITY MAP OF CUNNINGHAMIA KONISHII HAYATA UNDER CLIMATE CHANGE IN NORTHERN VIETNAM

Cunninghamia konishii Hayata is a rare and endangered plant species that plays a relevant role in ecological and commercial systems of natural forests in Vietnam. In this research, we evaluated the potential geographic distribution of C. konishii under current and future climatic conditions in Northern Vietnam using the ecological niche modelling approach based on the largest available database of occurrence records for this species. C. konishii is mainly distributed in the northern part of Vietnam at altitudes above 1000 m where the slopes range between 12 and 25 degrees, particularly in special-use and protected forest. The optimal distribution area of C. konishii requires specific climatic conditions: an annual precipitation around 1200 mm, precipitation of the warmest quarter ranging from 600 to 800 mm, a precipitation seasonality of 90 to100 mm, an annual mean temperature ranging from 12°C to 19 ° C, and a temperature seasonality ranging from 300 to 350. Additionally, the species requires specific soil groups: humic acrisols, ferralic acrisols, and yellow-red humic soils. Considering these requirements, the results of our research show that the suitable regions for the growth of C. konishii are found in the provinces of Ha Giang, Son La, Thanh Hoa and Nghe An, covering a total area of 1509.56 km 2 . However, analyzing the results under the Community Climate System Model version 4 (CCSM4) model, it is possible to observe that the area will decline to 504.39 km 2 by 2090 according to RCP 2.6 scenario, to 406.25 km 2 in the RCP 4.5 scenario, and to 47.62 km 2 in the RCP 8.5 scenario. The findings of this present research may be applied to several additional studies such as identifying current and future locations to establish conservation areas for C. konishii.
The Problem of Measurement Equivalence or Invariance in Instruments

: The purpose of this study is to discuss the validity of equivalence in the sample groups of young and adult; females and males in the scale of assessing the attitudes towards foreign language skills and to offer the researchers that will use this scale certain evidence based on data. No measurement equivalence/invariance was found in adult and young groups. Consequently, measurement equivalence / invariance based on gender variable was not present, either. The absence of measurement equivalence/invariance is in fact a fundamental proof that the measurement instrument is specific to the group that it is intended for. For this reason, researchers should evaluate cross-validity or multi-group analyses on the basis of the traits that are measured using the measurement instrument. It is not always negative not to have measurement equivalence/invariance during the process of gathering validity evidences.
Responsive Motion Control for Robot Soccer Navigation Using Adaptive Social Force Framework

This paper presents a modified Social Force Model (SFM) for navigation control of a soccer robot application. We modified the way of determining the parameter value of the gain factor, , of the SFM using the Fuzzy Inference System (FIS), so that the value of the gain factor, , is adaptive. The purpose of the gain factor adaptation is that the robot can move responsively but not over-reactive when it encounters an obstacle at high speed, which is a weakness of SFM with fixed parameters. Modification of SFM parameters using FIS is hereinafter referred to as the Fuzzy-based Social Force Model (F-SFM). We used this technique on a soccer robot with an omnidirectional drive platform with three motors. As an experiment, several modifications to the FIS rules were made and compared to the SFM with fixed parameters. The simulation-based experimental results show that the proposed method outperforms the SFM method with fixed-parameters, and the computation time does not differ significantly so that it can be applied for real implementation.
The Role of Wearable Monitor for Healthcare

Wearable monitor for healthcare was proposed in the late 1990s. Physiological monitoring in daily life has considerable potential for preventing and predicting diseases, without significant discomfort or inconvenience to the user. Over the past 25 years, wearable monitoring systems have been developed for health monitoring in daily life. In this presentation we will 1) review the devices used in wearable monitoring, including home use and clinical practice; 2) consider the evidence for their benefit in terms of healthcare outcomes; and 3) discuss long-term data collection and analysis using Big Data techniques. Furthermore, issues relating to the popularization of these devices are discussed, including regulation and business models. There are many promising devices available for wearable healthcare monitoring, and we propose ideas to popularize these devices.
Real Eﬀects of Risk Shocks in Housing Preferences Preliminary and incomplete: comments welcome

Even after the end of the recent Great Recession period, U.S. housing prices and real estate loans continued to decline, while the uncertainty associated with the housing market remained elevated. This paper shows that an increase in uncertainty with respect to housing demand, i.e. a time-varying second moment of housing preferences, generates these dynamics and implies adverse eﬀects for key macroeconomic aggregates such as output and consumption: An increase in housing preference volatility dampens housing prices which reduces the collateral value, borrowing activity and translates to a decrease in aggregate economic activity. Finally, we ﬁnd these results to be broadly in line with the data.
Pretreatment Leukocyte Count Ratios as Metastatic Predictive Factors in Luminal Type Breast Cancer

Objective: Molecular based predictive biomarkers have been developed but still unaffordable in developing countries. The leukocyte ratio is known as a promising, affordable and practical biomarker. However, the evidence to support their application is still lacking, especially from developing countries. Therefore, this study aimed to evaluate the association between leukocytes count ratios as predictive markers of metastasis in luminal type breast cancer. Methods: A retrospective cross-sectional study was conducted using breast cancer patient data obtained at Sanglah General Hospital (2016-2020). Complete blood count (CBC) and histopathological records of the patients were collected and the basophil-to-lymphocyte ratio (BLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) were calculated. Tumor stadium was classified into early (I-II) and advance (III-IV) stage while distant metastasis was classified into M0 and M1. Data were then analyzed using ROC curve and then followed by chi square and logistic regression analysis to obtain OR value. Results: Two hundred eighty-three luminal breast cancer patient data were used in this study with mean age 49.27 ± 9.451. Most of the patient had advanced disease (177 patients; 62.5%) while metastatic disease accounted for 54 patients (19.1%) of all patients. Patients with metastatic disease had higher median of BLR, MLR, NLR and PLR (0.043 ± 0.025, p=0.034; 0.289 ± 0.285, p=0.008; 3.489 ± 5.027, p=0.044; 159.538 ± 127.79, p=0.008) than patients without metastasis. The AUC (sensitivity and specificity) of BLR, MLR, NLR and PLR in predicting metastasis were 0.593 (51%; 65%), 0.616 (35%; 89%), 0.588 (46%; 75%) and 0.615 (40%; 81%), respectively. In multivariate risk analysis model, patients with metastasis were found in high BLR (Adjusted OR: 2.045; 95%CI=1.123-3.723; p=0.019), MLR (Adjusted OR: 4.862; 95%CI=2.401-9.844; p<0.001), NLR (Adjusted OR: 2.727; 95%CI=1.475-5.044; p=0.001) and PLR (Adjusted OR: 3.061; 95%CI=1.618-5.792; p=0.001). Conclusion: Pretreatment leukocyte ratios are potential predictive markers for metastasis. However, these findings need to be validated in larger and prospective studies with more comprehensive design.
Inhibitors of EYA3 Protein in Ewing Sarcoma

Objective: Among sarcomas, Ewing sarcoma (EWS) is characterized as a highly malignant type of bone tumor caused by the fusion of EWS RNA Binding Protein-1 (EWSR1)/ Friend leukemia integration 1 (FLI1) genes. The product of fusion gene gives rise to EWSR1/FLI1 which activates the activity of Eyes absent homolog 3 (EYA3) which causes tumor growth and angiogenesis. EYA3 is now considered as a therapeutic drug target for EWS . The study was designed to gather potential inhibitors for the EYA3 target using medicinal compounds. Methods: In this study, we have obtained a list of medicinal compounds from the NuBBE database and downloaded their structural information. Then insilico screening analysis of >2,000 medicinal compounds was performed with PyRX virtual drug screening software to discover potential inhibitors for the treatment of EWS. Results: Our investigation revealed that Sorbifolin and 1,7-Dihydroxy-3-methylanthracene-9.10-dione show interactive affinity for EYA3 active residues. Moreover, these compounds have adequate toxicity, can induce cytotoxicity in EWS cells, and are capable of regulating the expression of genes activated by EWSR1/FLI1. Conclusion: Our study concluded that Sorbifolin and 1,7-Dihydroxy-3-methylanthracene-9.10-dione are promising drug candidates for the treatment of EWS and should be further subjected to invitro testing.
Human Papillomavirus, Cytomegalovirus Infection and P16 Staining in Breast Tumors from Peruvian Women

Objective: To evaluate the frequency distribution of viral infections in Peruvian Breast Cancer (BC) lesions and its association with clinicopathological features. Additionally, a prospective evaluation of p16 and Tumor-infiltrating lymphocytes (TIL) levels were performed for developing a comprehensive analysis. Methods: Detection of high risk- human papillomavirus (HR- HPV) through qPCR was performed in 447 BC and 79 non-cancer frozen samples. Paired paraffin samples from 238 BC were stained with Human cytomegalovirus (HCMV) and p16 immunohistochemistry. TIL was calculated in 397 BC cases. Results: HCMV was positive in 72.5%. HR- HPV was detected in 2.9% of BC and 1.3% of non-malignant samples. P16+ was found in 28.15% and median TIL percentage was 30. HR- HPV infection was associated with non-ductal histology (p=0.003) and p16+ (p=0.017). Positive P16+ was associated with higher T stage (p=0.022), grade (p=0.009), TIL level (p=0.002), and triple-negative phenotype (p=0.021). Conclusion: HCMV is frequent, but HR- HPV infection is unusual in Peruvian BC. P16+ is associated with HR- PVH infection, high TIL and aggressive features.
CD8+ TILS Expression in Invasive Breast Carcinoma (No Special Type)

Invasive breast carcinoma (IBC) is the most cancer in women (24%) and the cause of cancer death in women worldwide. Based on data from globocan 2018 shows the incidence of breast cancer is around 2.08 million (11.6%) which is the second rank of all cancers after lung cancer with a mortality rate of 626.6 thousand (6.6%) which is also the most common cause of death in women. The basic role of the immune system in maintaining homeostasis by immunosurveillance and initiation of the inflammatory reactions that include coordination of innate and adaptive immune cells activation against tumor cells is one of the most important in the mechanism of tumor cell elimination. Prognosis of IBC were influenced by several factors, including tumor histology grade and Tumor Infiltrating Lymphocytes (TILs). Infiltration of lymphocytes in the tumor microenvironment/TILs through CD8+ T lymphocytes is known to be an important component of adaptive immunity that eliminates tumor cells. CD8+ T cells present tumor antigens on the surface of the major histocompatibility complex class I (MHC class I). Based on its importance in clinical application and it’s role in biological concepts, this study was conducted to determine the expression of CD8+ in Invasive Breast Carcinoma of No Special Type (IBC-NST) grades 1,2 and 3. Analytical study with a cross-sectional design on IBC-NST samples from 2017 until 2020 at the Laboratory of Anatomic Pathology, Faculty of Medicine, Hasanuddin University Makassar from May to August 2021. Immunoexpression data were analyzed to determine its relationship with grade. Eighty samples met the inclusion and exclusion criteria, there were 17 samples (21.3%) with grade 1, 32 samples (40%) with grade 2, and 31 samples (38.8%) with grade 3. In the high CD8+ TILs group, from a total of 27 samples, 10 samples with grade 1, 6 samples with grade 2, and as many as 11 samples with grade 3. In the low CD8+ TILs group, from a total of 53 samples, there were 7 samples with grade 1, 26 samples with grade 2, and 20 samples with grade 3. Based on the Chi-square test, p value = 0.017 (p <0.05). There is a significant difference in CD8+ TILS in Invasive Breast Carcinoma of No Special Type grade 1, grade 2 and grade 3.
Association between miR-196a-2 Gene Polymorphism and Ovarian Cancer Prognosis in Egyptian Females

Background: Ovarian cancer is the fifth leading cause of cancer-related deaths among women worldwide. Unfortunately, early detection tests are relatively lacking. Diagnosis in the late stages of the disease carries a poor prognosis. Objective: To evaluate the relationship between miR-196a-2 rs11614913 polymorphism and ovarian cancer risk and prognosis in Egyptian females. Methods: In this case-control study, the participants were classified into 2 groups. Group A is the control group which included 50 healthy females. Group B included 50 patients newly diagnosed with ovarian carcinoma confirmed by histopathological analysis. Immunohistochemistry for P53 and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for miR-196a-2 genotypes detection were performed. Results: There was a statistically significant difference among ovarian cancer cases and controls regarding genotypes (P = 0.003). However, the distribution of the T and C alleles in both studied groups showed no significant difference (P = 0.17). There was a statistically significant increase of CA 125 levels among CT and CC genotypes carriers of ovarian cancer cases (p = 0.04). Besides, there was a statistically significant correlation between miR-196a-2 polymorphism and each of tumor grade (P <0.001), p53 immunohistochemical expression (P= 0.002), and Figo classification (P <0.001). Conclusion: There was a statistically significant increase of CA 125 levels among C allele carriers of ovarian cancer cases. Besides, there was a statistically significant association between the miR-196a-2 polymorphism and each of tumor grade, p53 immunohistochemical expression, and Figo classification. So, miR-196a-2 polymorphism can be a possible prognostic factor in ovarian cancer.
S EGMENTATION OF T REK AND T RAIL R ACE R UNNERS AS T OURISTS

: This paper seeks to supplement the theory of sports marketing with additional knowledge on the participants in trek and trail races, provide basis for better understanding of their motives and behavior. The research instrument is a questionnaire consisting of 30 questions where the first part concerns with behavior at races; the second part consists of statements about the motives and the third part of descriptive questions. There were 194 participants who were interviewed by an online survey. The statistical analysis was conducted using factor analysis and cluster analysis. Five different factors / types of motivation and behavior of trek and trail race runners were extracted. Cluster analysis was also conducted and three cluster solutions were retained. Implications for marketing practice, limitations of the research and recommendations for future research were also given.
Rotary spatial phase shifter for reflect-array beamsteering

The paper details the theory and experimental results associated with an edge shorted circular disk antenna placed inside a square waveguide. It is shown how this arrangement can be made to perform the function of a spatial phase shifter for advanced reflect-array applications. Analysis for the arrangement is given and validation measurements were carried out in the L-band frequency range. The resonance of the disk is around 2.8 GHz. These results show that the reflected phase from the circular disk whose perimeter is short circuited with two metal pins peripherally oriented at angle φ follows the trend of 2φ reflected angle as the disk is rotated under circular polarised wave excitation.
Clinical Reviews: Drugs and Devices

The link between sudden unexplained death in individuals with mental health problems who are administered antipsychotic drugs has been recognised for over a century. A clear relationship has emerged over the past 25 years between antipsychotic drugs, prolongation of the QT interval of the ECG, atypical polymorphic tachycardia known as torsade de pointes (TdP) and sudden cardiac death (SCD). A number of antipsychotic drugs have been temporarily or permanently withdrawn from the market – or their use restricted – because of a concern over QT and QT corrected for heart rate (QTc) prolongation and development of TdP. In some cases, close follow-up with an ECG has been recommended or a modification of label imposed. The list of antipsychotic drugs implicated includes pimozide, sertindole, thioridazine, mesoridazine, promazine, triflupromazine, droperidol, moperone, pipamperone, sultopride and ziprasidone. A link between clinical use of antidepressants and the development of arrhythmias was first suggested following the Cardiac Arrhythmia Suppression Trial (CAST), based on the sodium channel-blocking properties of a number of antidepressant drugs including imipramine. Tricyclic antidepressants were subsequently shown to inhibit potassium channels and thus to prolong the QT interval and induce TdP. These effects of tricyclic antidepressants are generally observed when combined with other QT-prolonging agents or in cases of overdose. In addition, a number of case reports have linked tricyclic antidepressants as well as antipsychotic drugs to drug-induced Brugada syndrome (BrS), leading to syncope and SCD as a result of the development of rapid polymorphic ventricular tachycardia (VT) and VF. Our focus in this article is on mechanisms and predisposing factors underlying the development of cardiac arrhythmias and SCD associated with antidepressant and antipsychotic drugs in clinical use.
Navier-Stokes computations of missile aerodynamics

A computational and experimental investigation have been conducted for the prediction of missile flow fields with emphasis on subsonic and transonic flight conditions. The computational method is based on the thin shear layer formulation of the Navier-Stokes equations and a finite volume Runge-Kutta time marching algorithm. Computations performed for a missile model indicate that the salient flow features such as flow separation, and vortex formation are adequately predicted. In addition, good correlation is obtained between the computed and experimental surface pressure distributions, however, less agreement is obtained for turbulent flow conditions. Convergence performance of the numerical algorithm, numerical diffusion errors, and grid size effects are also discussed.