Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of coenzyme Q10 supplementation on cardiac troponin I level, heart rate variability, and echocardiographic profiles in canine with myxomatous degenerative mitral valve disease: a pilot study

The clinical benefits of Coenzyme Q10 (CoQ10) have been well documented in heart failure patients. In veterinary medicine, however, the clinical benefits of CoQ10 have not been well established in dogs with heart diseases. This study aimed to determine the effects of CoQ10 supplementation on 1) preventing myocardial injury 2) cardiac function 3) autonomic balance in dogs with myxomatous degenerative mitral valve disease (MMVD). Thirteen dogs with MMVD at ACVIM stage C were recruited in this study. Dogs were further divided into group I (Body weight [BW] < 6 kg.; n = 7) and group II (BW ≥ 6 kg.; n = 6). Cardiac troponin I (cTnI), echocardiographic examination, and 2 hours of Holter recording were performed on Day 0 and after receiving CoQ10 at 100 mg/dog twice daily for 28 days. CoQ10 caused a reduction of cTnI level in 71% of the dogs. Median cTnI tended to cause tended to decline but not significantly. Systolic function [i.e. fractional shortening (FS) and ejection fraction (EF)] increased significantly by 8 % and 9% (P < 0.05), respectively in group I after CoQ10 supplementation. Other echocardiographic parameters were not altered in either group. HRV analysis revealed no change in autonomic function and balance. cTnI negatively correlated with FS (P < 0.01) and positively correlated with LF/HF ratio (P < 0.05). In conclusion, this study demonstrated the clinical benefits of CoQ10 supplementation in dogs with MMVD. CoQ10 improves cardiac function in small dogs with MMVD. Finally, supplementation of CoQ10 in dogs should be based on body weight.
Arterial Intima-Media Thickness: Site-Specific Associations with Hormone Replacement Therapy and Habitual Exercise

We determined the site-specific relations of hormone replacement therapy (HRT) and habitual exercise status with intima-media thickness (IMT) in both elastic (carotid) and muscular (femoral) arteries in 77 healthy postmenopausal women: 43 sedentary: 20 no-HRT, 23 HRT users; and 34 endurance-trained: 14 no-HRT, 20 HRT. Femoral IMT was not different among the sedentary HRT and endurance-trained no-HRT and HRT groups, but was lower ( P <0.005) in these 3 groups than in the sedentary no-HRT women. There were no significant group differences in carotid IMT. However, in older women (>65 years) carotid IMT was smaller ( P <0.05) in HRT compared with no-HRT. We conclude that 1) both endurance-training and HRT status are independently associated with a smaller IMT and 2) these effects are evident primarily in muscular arteries. These results suggest that HRT and habitual exercise may protect postmenopausal women against CVD through influences on IMT. The site-specific relations may be due to a greater number of smooth muscle cells and plasticity of muscular arteries compared to elastic arteries, and/or differences in heterogeneous influences such as metabolic requirements and hydrostatic pressures.
GAMIFIED SYSTEMS FOR SECURITY AWARENESS

Users have a rather low security awareness, this has led to ideas about creating a security awareness system. By using gamification, it may be possible to motivate the user to change to a more secure behavior. The aim of this thesis is to study the relation between game elements, user and riskful behavior (context) in order to understand which game elements has a positive/negative effect on the users in which context. This was done by conducting a literature analysis, by collecting studies conducted with gamified system and compare and contrast their results. The literature analysis used four different databases and each of the databases was searched through by using four different search terms. The results shows that there seems to be lacking gamified system within security context, thus a conclusion could not be drawn from a literature analysis.
The Heterogeneity of White Adipose Tissue The Heterogeneity of White Adipose Tissue

The increasing prevalence of obesity is a major factor driving the worldwide epidemic of type 2 diabetes and metabolic syndrome. Adipose tissue not only stores energy, but also controls metabolism through secretion of hormones, cytokines, proteins, and microRNAs that affect the function of cells and tissues throughout the body. Accumulation of visceral white adipose tissue (WAT) leads to central obesity and is associated with insulin resis- tance and increased risk of metabolic disease, whereas accumulation of subcutaneous WAT leads to peripheral obesity and may be protective of metabolic syndrome. While much attention has been paid to identifying differences between white, brown and brite/ beige adipocytes, there is growing evidence that there is functional heterogeneity among white adipocytes themselves. This heterogeneity, includes depot-specific differences in development, inflammation, and endocrine properties. In addition to the depot-specific differences, even within a single fat depot, WAT is composed of developmentally and phenotypically distinct subpopulations of adipocytes. The following chapter will intro- duce this concept of white adipocyte heterogeneity.
Identification and Analysis of Long Noncoding RNAs and mRNAs in Chicken Macrophages Infected With Coronavirus Avian Infectious Bronchitis Virus

Background: Avian infectious bronchitis virus (IBV) is a gammacoronavirus that seriously affects the world's poultry industry Long non coding RNAs (lncRNAs), a subset of non coding RNAs greater than 200 nucleotides in length, have been recently recognized as pivotal factors during the pathogenesis of viral infection. However, how lncRNAs in host cul tured cells respond to IBV infection was little known. Herein, we detected the expression profiles of the mRNAs and lncRNAs in IBV infected HD11 cells. Results: By RNA seq, 2640 novel lncRNAs were identified, and 181 lncRNAs (59 up regulated lncRNAs , 122 down regulated lncRNAs) exhibited significant difference in expression levels in IBV infected HD11 cells compared with the uninfected. Based on the gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) data bases, the significant diff erentially expressed (DE) lncRNAs, such as MSTRG.25416. 43, MSTRG.6458. 31, MSTRG.14220. 1 and MSTRG.21445. 2, were mainly involved in the regulation of cellular innate immunity and amino acid, nucleic acid metabolism. In addition, 30 DE lncRNAs were screened out, and these lncRNAs may interact with gga miR 30d to regulate IBV replication. Conclusions:Our results provided novel insights into the functions of lncRNAs and the possible pathogenic mechanism following IBV infection.
Stress Impact on Industrial Area of Indian Managers

Abstract Advancements in science and technology has brought tremendous change in the life style of people which leading to higher stresses. Stressful situation at work place, disturbs the mental peace, weakens a person psychologically and create complexities in social and familial relationship. The present study analyzed the stress impact on managers of a selected industry in India. Standardized scales for stress assessment were used for estimating the stress of the subjects from private and public sector. Results revealed that on an average the managers had low stresses. Therefore, it was concluded that the increase or decrease of stress will have impact on quality, quantity of work and productivity of work.
Energy Management and Optimization in Smart Homes with Two-way Interchange of Energy between Electric Vehicle and Smart Home

: In this paper, two basic steps are taken to optimize and manage the energy of the smart home . In the first step, To provide a mathematical model and energy pattern to determine the temperature of the air conditioner thermostat with regard to climate change, so that ultimately the cost of consumed electricity is minimized and the welfare level of the smart home inhabitants will not fall below the definition. For this purpose, the neural network method has been estimated to have an instantaneous price for electricity in the coming days, with external temperature information outside the home and the current price of electricity in recent days. Then, using the PSO algorithm, the thermostat setting temperature is determined to optimize energy consumption and minimize the cost of consumable electricity. In the second step, while extracting the equivalent electric vehicle load and power consumption to charge it, the technical and economical analysis of providing smart home power supply through the storage battery of the electric vehicle is considered, so that according to the instantaneous electricity price calculated in the first step At a time when the cost of purchasing electric power from the electric network is high, the battery will provide electric power to the smart home power. Economic analysis results show savings on the cost of purchasing electrical energy with the proposed idea of this paper.
413 Changes in Chromatin Accessibility Across the GM-CSF Promoter upon T Cell Activation Are Dependent on Nuclear Factor (cid:2) B

Australia Abstract Granulocyte/macrophage colony-stimulating factor (GM-CSF) is a key cytokine in my-elopoiesis and aberrant expression is associated with chronic inflammatory disease and myeloid leukemias. This aberrant expression is often associated with constitutive nuclear factor (NF)- (cid:2) B activation. To investigate the relationship between NF- (cid:2) B and GM-CSF transcription in a chromatin context, we analyzed the chromatin structure of the GM-CSF gene in T cells and the role of NF- (cid:2) B proteins in chromatin remodeling. We show here that chromatin remodeling occurs across a region of the GM-CSF gene between (cid:3) 174 and (cid:4) 24 upon T cell activation, suggesting that remodeling is limited to a single nucleosome encompassing the proximal promoter. Nuclear NF- (cid:2) B levels appear to play a critical role in this process. In addition, using an immobilized template assay we found that the ATPase component of the SWI/SNF chromatin remodeling complex, brg1, is recruited to the GM-CSF proximal promoter in an NF- (cid:2) B–dependent manner in vitro. These results suggest that chromatin remodeling across the GM-CSF promoter in T cells is a result of recruitment of SWI/SNF type remodeling complexes by NF- (cid:2) B proteins binding to the CD28 response region of the biotinylated sense primer. After digestion at restriction enzyme sites in the primers, the PCR product was radiolabeled with 32 P (cid:5) -dATP using Klenow DNA polymerase. Nucleosomes were assembled onto the DNA by the salt gra-dient dialysis method (33). Mock assembled and nucleosome assembled DNA was incubated with 10–40 units of HinfI restriction enzyme, electrophoresed through 5% polyacrylamide/ 1 (cid:7) TBE and visualized using the Fuji PhosphorImager. anti-Sp1
Mammalian Target of Rapamycin Cell Signaling Pathway Contributes to the Protective Effects of Ischemic Postconditioning Against Stroke Basic

is controversial, and whether it is involved in the protective effects of ischemic postconditioning (IPC) against stroke is unreported. Our study focuses on the protective role of mTOR against neuronal injury after stroke with and without IPC. Methods —We used both an in vitro oxygen–glucose deprivation model with a mixed neuronal culture and hypoxic postconditioning, as well as an in vivo stroke model with IPC. Rapamycin, a specific pharmacological inhibitor of mTOR, and mTOR short hairpin RNA lentiviral vectors were used to inhibit mTOR activity. A lentiviral vector expressing S6K1, a downstream molecule of mTOR, was used to confirm the protective effects of mTOR. Infarct sizes were measured and protein levels were examined by Western blot. Results —We report that stroke resulted in reduced levels of phosphorylated proteins in the mTOR pathway, including S6K1, S6, and 4EBP1, and that IPC increased these proteins. mTOR inhibition, both by the mTOR inhibitor rapamycin and by mTOR short hairpin RNA, worsened ischemic outcomes in vitro and in vivo and abolished the protective effects of hypoxic postconditioning and IPC on neuronal death in vitro and brain injury size in vivo. Overexpression of S6K1 mediated by lentiviral vectors significantly attenuated brain infarction. Conclusions —mTOR plays a crucial protective role in brain damage after stroke and contributes to the protective effects of IPC. ( Stroke . 2014;45:2769-2776.) Oxygen–glucose deprivation (OGD) was induced for 6 hours in a hypoxic chamber, and in vitro hypoxic postconditioning (HPC) was performed by 3 cycles of 15-minute restoration of glucose and oxy- gen and 15-minute OGD. Cell viability was quantified by measuring lactate dehydrogenase release 18 hours after OGD restoration using a previously described colorimetric assay. 18 The effects of rapamycin, mTOR shRNA, and S6K1 vectors on neuronal injury were studied.
THE LAXATIVE IN

Background: Constipation affects all age groups around the world and almost half of patients not satisfied with the current treatment. Grewia ferruginea is commonly growing plant in Ethiopia and used traditionally for treating many ailments including constipation while not approved scientifically yet. Therefore, the present study was intended to evaluate the laxative activity of 80% methanol extract of the leaves of G. ferruginea. Objective : To evaluate in vivo laxative activity of 80% methanol extract of the leaves of Grewia ferruginea Hochst. ex. A. Rich (Tiliaceae) in Swiss albino mice. Methods : The methanolic leaves extract of G. ferruginea were administered to the loperamide induced constipated mice. Group I, II, III, IV and V consist of constipated mice, treated for five days with vehicle, 100, 200 and 400mg/kg of crude extract and standard drug respectively. Another one group consists of normal mice was given vehicle for the same duration. After five days treatments the total number, weight of wet and dry feces as well as the water content of feces were calculated. The gastrointestinal motility test was done using charcoal meal in loperamide induced constipated mice. The gastrointestinal secreting effect of the crude extract was also determined in normal mice. Preliminary phytochemical screening was done. The result was expressed as mean±SEM. Statistical analysis was done using one way ANOVA followed by posthoc Tucky test and p<0.05 considered as significant. Results: Loperamide treated mice showed decrease frequency, wet weight and fecal moisture content compared to normal control. After five days treatment, with all doses of crude extract the weight of wet feces and percentage of fecal water content were increased significantly compared to constipated control. There was no significant difference in frequency of defecation. The gastrointestinal transit ratio and secreting effect of G. ferruginea were significant at 200mg/kg and 400mg/kg (p<0.01). Preliminary phytochemical screening showed that the crude extract contains phenols, flavonoids, steroids, saponins and tannins. Conclusion: The crude extract of the leaves of G. ferruginea showed hopeful laxative activity in mice at least in part via increasing intestinal motility and secretion.
of Web APIs

Modelling and understanding various contexts of users is im-portant to enable personalised selection of Web APIs in directories such as Programmable Web. Currently, relationships between users and Web APIs are not clearly understood and utilized by existing selection approaches. In this paper, we present a semantic model of a Web API directory graph that captures relationships such as Web APIs, mashups, developers, and categories. We describe a novel conﬁgurable graph-based method for selection of Web APIs with personalised and temporal aspects. The method allows users to get more control over their preferences and recommended Web APIs while they can exploit information about their social links and preferences. We evaluate the method on a real-world dataset from ProgrammableWeb.com, and show that it provides more contextualised results than currently available popularity-based rankings.
Interpretation of association rules with multi-tier granule mining

This study was a step forward to improve the performance for discovering useful knowledge – especially, association rules in this study – in databases. The thesis proposed an approach to use granules instead of patterns to represent knowledge implicitly contained in relational databases; and multi-tier structure to interpret association rules in terms of granules. Association mappings were proposed for the construction of multi-tier structure. With these tools, association rules can be quickly assessed and meaningless association rules can be justified according to the association mappings. The experimental results indicated that the proposed approach is promising.
Investigation of Combustion and Emission Characteristics of Diesel/Bio-Diesel Blends under Oxygenated Fuel Burner.

: The study of the flame characteristics and emissions of oxy fuel combustion of diesel and diesel biodiesel blends is performed using an experimental test burner manufactured for this reason in a laboratory scale. The fuels used are the conventional diesel fuel and a mixture of diesel and bio-diesel (B0, B10, B20, and B40) when the number refers to the bio-diesel percentage in the blend, In this present paper the behavior change of CO, CO2, HC, and NOx emissions was investigated for the selected blends with the increasing of oxygen concentration gradually by an oxygen cylinder to the air consumed in combustion. The flame characteristics (cone angle, flame length and appearance) also studied with the oxygen concentration change. It was observed that the carbon monoxide, carbon dioxide, unburned hydrocarbons, NOx, and the temperature are higher in diesel than bio-diesel blends in air combustion and in oxy- combustion. This may because the number of hydrogen and carbon atoms is more in conventional diesel than bio-diesel, also the calorific value, so the temperature is higher. The flame cone angle and flame penetration length decreased after the addition of oxygen and bio-diesel, this is due to the presence of sufficient amount of oxygen which causes early chemical reaction between the fuel and oxidizer. By using oxy fuel combustion of renewable sources we can save money spent in conventional petroleum fuel.
Progress in Metabolic Engineering of Saccharomyces cerevisiae lignocellulosic biomass

Department of Microbiology and Genetics, Berlin University of Technology, Seestr. 13, 13353 Berlin, Germany; Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, bus 2438, B-3001 Heverlee, Flanders, Belgium; and Department of Molecular Microbiology, VIB, Kasteelpark Arenberg 31, bus 2438, B-3001 Heverlee, Flanders, Belgium
Using a Synthetic Probe to Study the Robustness of the Segregation Process of Protein Aggregates in Escherichia coli

—Even though the processes of protein production and folding are not immune to errors, Escherichia coli lineages are capable to maintain a stable cell lineage, provided viable environmental conditions. One of the internal processes that makes this possible consists of segregating unwanted protein aggregates to the cell poles by nucleoid exclusion, which, combined with cell divisions, generates asymmetries in the aging process of the population, with some individuals aging faster while others exhibit rejuvenation. A recent study showed that this process is not immune to sub-optimal temperature conditions due to increased cytoplasm viscosity, which weakens the anisotropy in aggregate displacements at the nucleoid borders. This was made possible by the usage of a synthetic fluorescent probe, consisting of a RNA sequence with multiple binding sites for the MS2-GFP synthetic protein, which can be tracked in time-lapse microscopy images. Here we provide a description of the findings from these measurements and investigate with an In Silico model the consequences in the context of cell lineages.
The Ghosts of the École Normale Life, death and legacy of René Gateaux 1

The present paper deals with the life and some aspects of the scientiﬁc contributions of the mathematician René Gateaux, killed during World War I at the age of 25. Though he died very young, he left interesting results in functional analysis. In particular, he was among the ﬁrst to try to construct an integral over an inﬁnite-dimensional space. His ideas were extensively developed later by Paul Lévy. Among other things, Lévy interpreted Gateaux’s integral in a probabilistic framework that later contributed to the construction of the Wiener measure. This article tries to explain this singular personal and professional destiny in pre- and postwar France.
An Application of Fuzzy Ergonomic Assessment for Human Motion Analysis in Modular Construction

Work-related Musculoskeletal Disorders (WMSDs) account for about 34% of non-fatal injuries resulting in days away from work in the construction industry. Particularly in modular construction, due to the repetitive nature of the manual tasks, workers are highly exposed to ergonomic risks. To identify workers’ awkward postures that potentially lead to WMSDs, ergonomic assessment tools have been developed and widely used by ergonomists and Occupational Health and Safety (OHS) practitioners. However, the accuracy of these methods is highly affected by the subjectiveness towards the user’s inputs (e.g., body joint angles), which are difficult to accurately determine in given observation time. Consequently, the imprecise estimates of worker postures may result in inaccurate final results and risk intervention plans. In an effort to address this issue, this study applies fuzzy logic techniques to ergonomic evaluation tools—e.g., Rapid Upper Limb Assessment (RULA). By modelling the range of input values using fuzzy sets rather than discrete boundaries, the imprecision inherit in the inputs has less impact on the final RULA score. As a result, an automated fuzzy expert system has been developed by using membership functions and rules created based on the existing RULA method. An experiment is carried out in order to study the amount of imprecision in joint angle values from human estimations while observing a posture, and also to compare the sensitivity of RULA and the developed fuzzy RULA system to input imprecision. The results reveal that although the fuzzy RULA model has high correlation with RULA, it is more accurate and less sensitive to the variance in input values. The developed model presents a methodology to improve the accuracy of ergonomic assessment methods and handle the uncertainty inherent in ergonomic evaluation, providing the construction industry practitioners with an automated technique to evaluate the ergonomic safety of workers.