Miracle-dz/UniFAR-FTUs huggingface dataset:
Inhibin a and 13A Subunit Messenger Ribonucleic Acids Expression in Human Pituitary Adenomas: Studies by Quantitative Reverse Transcription-Polymerase Chain Reaction

Inhibin a and NA subunit messenger ribonucleic acid (mRNA) levels were measured quantitatively by reverse transcription-polymerase chain reaction (RT-PCR) in human pituitary adenomas. The inhibin a subunit mRNA levels were undetectably low in cultured adenoma tissues, but F3A mRNA were 0.383 ± 0.074 in 3 GH adenomas, 0.672 ± 0.140 in 3 prolactinomas and 0.957 ± 0.414 molecules/cell in 3 non-functioning adenomas. The addition of 10.8 M activin A decreased the NA mRNA levels within 4 h in 1 of 3 GH adenomas, 2 of 3 prolactinomas and 2 of 3 non-functioning adenomas, though the decreases were not statistically significant. The results showed an abundance of IA subunit mRNA compared with a subunit mRNA in all human pituitary adenomas and a local role for activin in its own production through inhibin 13A mRNA subunit expression.
Development of Mouthpiece Type Remote Controller for Severely Disabled People

We have tried to develop a mouthpiece type remote controller for severely disabled people such as those with cervical cord injuries and/or muscular dystrophies. This remote controller would be inserted into the user’s mouth and be operated by tongue movement. Tongue movement is one of the voluntary functions that usually retains its function, even in the case of cervical cord injury. The specification of the mouthpiece type remote controller is explained. The performance and operativeness are evaluated in this paper. We developed a 4 channel remote controller to operate a powered wheelchair; forward, right, left and backward. This controller has four passive RFID ( Radio Frequency IDentification ) transponders. Each transponder generates electric power by itself, so it can work without a battery. The MCR ( Maximum Communication Range [ mm ]) was evaluated in three conditions of atmosphere, water and meat. The MCR was 110mm or more in every condition. In the case of the remote controller being inserted into the participant’s mouth, the performance of the MCR satisfies the design specification. With this system, we succeeded in operating an electric powered wheelchair on the market.
Over there: rethinking American First World War literature and culture – Introduction

ABSTRACT This Special Issue of First World War Studies considers the specifically American literary and cultural production of the First World War and what distinguishes it from other national war literatures and cultures. Together the articles seek to assess how we should characterize, theorize and categorize American First World War cultural production. Despite the many memorials and memory sites to American participation, and the impact of the recent centenary, public memory of the conflict in the US remains minimal, overshadowed by the Civil War on one side and the Second World War and the Vietnam War on the other. The Eurocentric focus of the key works of First World War cultural criticism – by Paul Fussell, Samuel Hynes, Modris Eksteins and Jay Winter – is perhaps due to what Hazel Hutchison notes as the strange place of the war in American cultural memory, as a war which ‘has never quite captured the public imagination’ (The War That Used Up Words: American Writers and the First World War, 2015). Instead it is usually focused through the ‘lost generation’ writers of the 1920s: Hemingway, Faulkner, Fitzgerald, et al. Bringing together a range of scholars and drawing predominantly on literature and film by male and female non-combatants as well as participants, the case studies here consider American First World War novels, poetry, political papers, film, and screenplays. Interdisciplinary readings allow the contributors to find generic tropes and connections across different media. In this way we seek to contribute to an ongoing conversation about American First World War cultural production, and a critical field that is very much still in the process of formation and consolidation.
Distribution and Abundance of the Glossy Ibis (Plegadis falcinellus) in Wintering and Breeding Grounds in Northeast Algeria

ABSTRACT Atmospheric conditions play an important role in structuring avian communities in space and time. Here we assess the role of weather conditions on the distribution and abundance of the enigmatic glossy ibis (Plegadis falcinellus) in Northeast Algeria in both wintering grounds and in breeding areas in a survey spanning from 2011 to 2019. During the study period, cooler years were wetter and warmer years were drier. The wintering population size in the region could be estimated to 200-300 individuals. The number of individuals in wintering grounds increased in recent years in one site (Berrihane), but it did not show a strong association with weather conditions prior to wintering. Four breeding colonies were detected in highly-vegetated ponds with in-water trees where the number of breeding pairs was the highest. Extinction was recorded for two colonies (50% of colonies) where one permanently disappeared and one exhibited a series of extinctions and recolonizations across years. The estimated colony size was larger at El Dakhla (60–105 pairs) than El Chatt (0–42 pairs), Fezara Lake (25–41 pairs), and Tonga Lake (0–2 pairs). Climate conditions seemed to correlate with the number of pairs in one site (El Chatt) such that warm and dry years were associated with lower number of individuals. We discuss that disturbance and pollution might play a role in colony establishment but the number of pairs is positively related to the extinction of a nearby colony, suggesting that those refuge colonies are crucial for the persistence of the species in the area. This study presents historical data on the occurrence and abundance of a relatively unstudied species and gives new information on its climatic sensitivity which might be helpful for predicting future climate change impacts.
The design, modelling and control of an autonomous tethered multirotor UAV

This work details the design, modelling, control and successful demonstration of a tethered multirotor UAV system; as a first iteration towards an alternative, and more accessible, persistent aerial platform. The project focusses specifically on the development of appropriate modelling and flight control strategies, in addition to the development of a suitable practical testing platform. The tether model is developed based on the assumption of a quasi-static catenary, which sufficiently encapsulates the dominant tether forces. The flight control strategy is catered towards the civilian landscape with a minimalist sensor configuration that aims to keep the system simple and cost-effective. A conventional control system is initially developed for the untethered system, and thereafter adapted to cater for the unique aspects of tethered flight. The control architecture implements variations of linear PID control in a successive loop closure approach. A physical test platform is developed consisting of a 0.8 m×0.8 m quadrotor vehicle, modified to accommodate a tether. Results are presented for hardware-in-the-loop simulations as well as practical flight tests. The practical flight tests served to successfully demonstrate the developed flight control strategy, in addition to providing insight into some of the observed idiosyncrasies of tethered flight. ii Stellenbosch University https://scholar.sun.ac.za
Unveiling the competitive role of global modes in the pattern formation of rotating sphere flows

Abstract The wake flow past a streamwise rotating sphere is a canonical model of numerous applications, such as particle-driven flows, sport aerodynamics and freely rising or falling bodies, where the changes in particles’ paths are related to the destabilization of complex flow regimes and associated force distributions. Herein, we examine the spatio-temporal pattern formation, previously investigated by Lorite-Díez & Jiménez-González (J. Fluid Mech., vol. 896, 2020, A18) and Pier (J. Fluids Struct., vol. 41, 2013, pp. 43–50), from a dynamical system perspective. A systematic study of the mode competition between rotating waves, which arise from the linearly unstable modes of the steady-state, exhibits their connection to previously observed helical patterns present within the wake. The organizing centre of the dynamics turns out to be a triple Hopf bifurcation associated with three non-axisymmetric, oscillating modes with respective azimuthal wavenumbers $m=-1,-1$ and $-2$. The unfolding of the normal form unveils the nonlinear interaction between the rotating waves to engender more complex states. It reveals that for low values of the rotation rate, the flow field exhibits a similar transition to the flow past the static sphere, but accompanied by a rapid variation of the frequencies of the flow with respect to the rotation. The transition from the single helix pattern to the double helix structure within the wake displays several regions with hysteric behaviour. Eventually, the interaction between single and double helix structures within the wake lead towards temporal chaos, which here is attributed to the Ruelle–Takens–Newhouse route. The onset of chaos is detected by the identification of an invariant state of the normal form constituted by three incommensurate frequencies. The evolution of the chaotic attractor is determined using of time-stepping simulations, which were also performed to confirm the existence of bi-stability and to assess the fidelity of the computations performed with the normal form.
Gesundheitskompetenz: Systeme, Organisationen und Individuen

Zusammenfassung Gesundheitskompetenz ist der Grad, zu dem Individuen durch das Bildungs-, Sozial- bzw. Gesundheitssystem in die Lage versetzt werden, die für angemessene gesundheitsbezogene Entscheidungen relevanten Gesundheitsinformationen zu finden, zu verarbeiten und zu verstehen. Individuelle Fähigkeiten dürfen nicht die Voraussetzung sein, in einem komplexen Gesundheitssystem zurechtzukommen, sondern es ist vielmehr das System, das der Komplexität der Menschen gerecht werden muss.
Design, synthesis, and biological evaluation of N‐[1‐(6′‐chloropyridazin‐3′‐yl)‐3‐(4″‐substitutedphenyl)‐1H‐pyrazole‐5‐yl]alkanamides as anti‐inflammatory agents

A series of structurally diverse N‐[1‐(6′‐chloropyridazin‐3′‐yl)‐3‐(4″‐substitutedphenyl)‐1H‐pyrazole‐5‐yl]alkanamides 5(a–r) has been designed and synthesized via Aliquat 336 catalyzed amidation of 5‐amino‐3‐aryl‐1‐(6′‐chloropyridazin‐3′‐yl)pyrazoles 3(a–c). The target compounds were designed on basis of the results obtained from the study of Lipinski's rule of five and binding interactions with target protein 3LN1. Eventually, compounds 5(a–r) were screened for their in vitro anti‐inflammatory action by using inhibition of albumin denaturation and membrane stabilization assay. It has been found that all the synthesized compounds obeyed Lipinski's rule of five (nviolations = 0–1) and showed weak to strong binding interactions with dock score range −8.0 to −9.9 kcal/mol. All alkanamides exhibited moderate to excellent activity as compared to the standard drug, Aspirin. Interestingly, the results indicated that the compound 5a may act as a promising medicinal lead as an anti‐inflammatory agent for in vivo and clinical testing in future.
Diseño de transiciones de banda ancha entre línea coplanar y guía de onda Empty Substrate Integrated Coaxial Line

Current telecommunications systems are under pressure from their customers, who are increasingly demanding speed. For this reason systems must have high performance devices that have to adapt their characteristics to the environment in which they are. This project aims to help start a new series of variable responses’s devices by using the novel empty substrate integrated coaxial line (ESICL) filled by liquid crystal. This project should design a transition between the ESICL filled by liquid crystal and the transmission line coplanar waveguide with ground for its future manufacturing.
Single-electron switch for phase-locked single-electron logic devices

Single-electron switch is proposed and analysed as a basic logic/memory component, in which binary unity/zero is represented by the presence/absence of a single-electron and the binary codes can be exchanged between different nodes by changing external biases. To realise single-electron switch, a novel side-gated FET structure is proposed. The performance of phase-locked single-electron logic, which is constructed by single-electron switches, is analysed from the measured tunnelling characteristics. <<ETX>>
Remediation of Chlorinated Aliphatic Hydrocarbons (CAHs) in Groundwater by Enhanced Anaerobic Bioremediation with Poly-lactate Ester

Hydrogen release compound, which is mainly composed of poly-lactate ester, was injected into one chlorinated aliphatic hydrocarbons (CAHs) contaminated site through injection well rows for enhancing bioremediation process and preventing contaminated groundwater from flowing out of the site. Its remediation effect as a permeable biobarrier to treat CAHs contaminated groundwater and its influence on microorganism environment in subsurface aquifer were investigated. CAHs remediation effect was confirmed that concentrations of primary source contaminant tetrachloroethene and its daughter products decreased after the hydrogen release compound injection and half-lives of these products substantially decreased after that. Subsurface aquifer microorganism environment change after the hydrogen release * 国際航業(株)地 盤環境 エ ンジニア リング事業部 Geo-Environmental Division, Kokusai Kogyo Co., Ltd. つくば環境微生物研究所 Tsukuba Environmental Microorganism Institute *** 筑波大学応用生物化学系 Institute of Applied Biochemistry, Tsukuba University **** 佐賀大学農学部応用生物化学科 Department of Applied Biological Sciences, Faculty of Agriculture, Saga University ***** 岡山大学環境理工学部環境デザイン工学科 Department of Environmental and Civil Design, Faculty of Environmental Science and Technology, Okayama University
Analisis Sistem Dan Teknologi Informasi Sebagai Acauan Dalam Perancangan Rencana Strategis Sistem Informasi Dan Teknologi Informasi (Renstra Si/Ti) Di Rumah Sakit Islam Yogyakarta Pdhi

In general the use of IS / IT within the Islamic Hospital in Yogyakarta PDHI less than optimal and not show the direction of good information systems development. Then not supported by the management system and work processes that are effective, and there is no strategic plan for the development of the IS / IT. This study aimed to analyze the information systems and information technology, which can be used to base the development of the strategic plan of IS / IT in Islamic Hospital Yogyakarta PDHI. This study is case study, using a qualitative approach. Collecting data in this study using interviews, FGD to management and observation, as well as the review of the document. This study tries to identify the conditions and needs of organizations in planning strategies IS / IT RSIY PDHI. Islamic Hospital Yogyakarta PDHI already implementing HIS, but the existing information systems is not supported by legal documents used as a referral organization in the development of the IS / IT, other than that related to the architecture of IS / IT and the development of HIS is already done, shows that RSIY PDHI not conform with existing standards and protocols. There is still a gap between the conditions of IS / IT in RSIY PDHI standards of governance and architecture / IT, as well as management standards HIS.
IVIM Imaging of Paraspinal Muscles Following Moderate and High-Intensity Exercise in Healthy Individuals

Background Quantification of the magnitude and spatial distribution of muscle blood flow changes following exercise may improve our understanding of the effectiveness of various exercise prescriptions. Intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) is a technique that quantifies molecular diffusion and microvascular blood flow, and has recently gained momentum as a method to evaluate a muscle's response to exercise. It has also been shown to predict responses to exercise-based physical therapy in individuals with low back pain. However, no study has evaluated the sensitivity of IVIM-MRI to exercise of varying intensity in humans. Here, we aimed to evaluate IVIM signal changes of the paraspinal muscles in response to moderate and high intensity lumbar extension exercise in healthy individuals. Methods IVIM data were collected in 11 healthy volunteers before and immediately after a 3-min bout of moderate and high-intensity resisted lumbar extension. IVIM data were analyzed to determine the average perfusion fraction (f), pseudo-diffusion coefficient (D*), and diffusion coefficient (D) in the bilateral paraspinal muscles. Changes in IVIM parameters were compared between the moderate and high intensity exercise bouts. Results Exercise increased all IVIM parameters, regardless of intensity (p < 0.003). Moderate intensity exercise resulted in a 11.2, 19.6, and 3.5% increase in f, D* and D, respectively. High intensity exercise led to a similar increase in f (12.2%), but much greater changes in D* (48.6%) and D (7.9%). Conclusion IVIM parameter increases suggest that both the moderate and high-intensity exercise conditions elicited measurable changes in blood flow (increased f and D*) and extravascular molecular diffusion rates (increased D), and that there was a dose-dependence of exercise intensity on D* and D.
Case Report: Recurrent Hemiplegic Migraine Attacks Accompanied by Intractable Hypomagnesemia Due to a de novo TRPM7 Gene Variant

Transient receptor potential melastatin 7 (TRPM7) is a ubiquitously expressed chanzyme comprised of a divalent cation channel permeable to calcium and magnesium and a cytosolic serine-threonine α-kinase domain. TRPM7 has a crucial role in magnesium ion homeostasis and anoxic neuronal death, which was identified as a potential non-glutamate target for hypoxic-ischemic neuronal injury. TRPM7 is implicated in ischemic stroke and hypomagnesemia in many studies, but it has not been associated with disease in the OMIM database. No clinical cases between TRPM7 gene variants and hypomagnesemia have been reported, so far. One patient with recurrent hemiplegic migraine attacks accompanied by intractable hypomagnesemia was followed up at Tianjin Children’s Hospital from 2018 to 2021. We systematically summarized and analyzed the clinical manifestations, imaging features, and serum magnesium changes of the patient. Genetic analysis was performed by whole-exome sequencing and Sanger sequencing to infer the etiology of hemiplegic migraine attacks and hypomagnesemia in this patient. Gene sequencing revealed a novel heterozygous variant of the TRPM7 gene (c.2998A>G, p. Met1000Val), which has not been reported previously; this is also a de novo variant that is not inherited from his parents. We described a novel variant p. Met1000Val (c.2998A>G) located in the transmembrane region of TRPM7 protein, which is possibly crucial for the normal function of the ion channel. Our study expands the variation spectrum of the TRPM7 gene, highlights the importance of molecular genetic evaluation in patients with TRPM7 gene deficiency, and demonstrates the causal relationship between TRPM7 gene variants and disease manifestations.
Redefining the Foreign Antigen and Self-Driven Memory CD4+ T-Cell Compartments via Transcriptomic, Phenotypic, and Functional Analyses

Under steady-state conditions, conventional CD4+ T lymphocytes are classically divided into naïve (CD44lo CD62Lhi) and memory (CD44hi CD62Llo) cell compartments. While the latter population is presumed to comprise a mixture of distinct subpopulations of explicit foreign antigen (Ag)-specific “authentic” memory and foreign Ag-independent memory-phenotype (MP) cells, phenotypic markers differentially expressed in these two cell types have yet to be identified. Moreover, while MP cells themselves have been previously described as heterogeneous, it is unknown whether they consist of distinct subsets defined by marker expression. In this study, we demonstrate using combined single-cell RNA sequencing and flow cytometric approaches that self-driven MP CD4+ T lymphocytes are divided into CD127hi Sca1lo, CD127hi Sca1hi, CD127lo Sca1hi, and CD127lo Sca1lo subpopulations that are Bcl2lo, while foreign Ag-specific memory cells are CD127hi Sca1hi Bcl2hi. We further show that among the four MP subsets, CD127hi Sca1hi lymphocytes represent the most mature and cell division-experienced subpopulation derived from peripheral naïve precursors. Finally, we provide evidence arguing that this MP subpopulation exerts the highest responsiveness to Th1-differentiating cytokines and can induce colitis. Together, our findings define MP CD4+ T lymphocytes as a unique, self-driven population consisting of distinct subsets that differ from conventional foreign Ag-specific memory cells in marker expression and establish functional relevance for the mature subset of CD127hi Sca1hi MP cells.
Integrated Analysis of miRNA-mRNA Expression in Mink Lung Epithelial Cells Infected With Canine Distemper Virus

Canine distemper (CD) caused by canine distemper virus (CDV) is one of the major infectious diseases in minks, bringing serious economic losses to the mink breeding industry. By an integrated analysis of microRNA (miRNA)-messenger RNA (mRNA), the present study analyzed the changes in the mink transcriptome upon CDV infection in mink lung epithelial cells (Mv. l. Lu cells) for the first time. A total of 4,734 differentially expressed mRNAs (2,691 upregulated and 2,043 downregulated) with |log2(FoldChange) |>1 and P-adj<0.05 and 181 differentially expressed miRNAs (152 upregulated and 29 downregulated) with |log2(FoldChange) |>2 and P-adj<0.05 were identified. Gene Ontology (GO) enrichment indicated that differentially expressed genes (DEGs) were associated with various biological processes and molecular function, such as response to stimulus, cell communication, signaling, cytokine activity, transmembrane signaling receptor activity and signaling receptor activity. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the combination of miRNA and mRNA was done for immune and inflammatory responses, such as Janus kinase (JAK)-signal transducer and activator (STAT) signaling pathway and nuclear factor (NF)-kappa B signaling pathway. The enrichment analysis of target mRNA of differentially expressed miRNA revealed that mir-140-5p and mir-378-12 targeted corresponding genes to regulate NF-kappa B signaling pathway. JAK-STAT signaling pathway could be modulated by mir-425-2, mir-139-4, mir-140-6, mir-145-3, mir-140-5p and mir-204-2. This study compared the influence of miRNA-mRNA expression in Mv. l. Lu cells before and after CDV infection by integrated analysis of miRNA-mRNA and analyzed the complex network interaction between virus and host cells. The results can help understand the molecular mechanism of the natural immune response induced by CDV infection in host cells.