Miracle-dz/UniFAR-FTUs huggingface dataset:
Dual Target of EGFR and mTOR Suppresses Triple-Negative Breast Cancer Cell Growth by Regulating the Phosphorylation of mTOR Downstream Proteins

Objective To detect the activation of the EGFR and mTOR signaling pathways in the triple negative breast cancer cell line MDA-MB-468 and investigate the inhibitory effect of gefitinib, an epidermal growth factor receptor inhibitor, and everolimus, a target protein inhibitor of rapamycin, on triple negative breast cancer cells. Methods Triple negative human breast cancer MDA-MB-468 cells were cultured and blank control group, single EGFR inhibitor gefitinib group, single mTOR inhibitor everolimus group, and two drug combination group were set up respectively to detect the effects of single and combined drugs on cell proliferation activity, cell cycle and apoptosis, and the expression of EGFR and mTOR signal pathway proteins in cell lines after single and combined drug intervention was detected again by Western blot. Results The level of EGFR and p-mTOR protein in triple negative breast cancer was higher than in non triple negative breast cancer (P<0.05). The level of mTOR, S6K1, p-EGFR, p-S6K1 was significantly increased when treated with EGF (0ng/mL, 10ng/mL, 100ng/mL) for 1h, compared to without EGF stimulation (P<0.05). The level of p-EGFR, p-mTOR, p-S6K1 protein increased significantly when the cells were exposed to EGF for 2h, respectively (P<0.05). EGFR inhibitor gefitinib alone and the mTOR inhibitor everolimus alone could significantly inhibit the proliferation of human triple negative breast cancer MDA-MB-468 cells in a dose-dependent manner (P<0.05). The level of p-4EBP1 protein in EGFR and mTOR signal pathway was significantly increased after the intervention of gefitinib alone, everolimus alone, and the combination of two drugs (P<0.05). Conclusion EGFR and mTOR signaling pathways can be activated in triple negative breast cancer; Both the EGFR inhibitor gefitinib alone and the mTOR inhibitor everolimus alone can significantly inhibit the proliferation of human triple negative breast cancer MDA-MB-468 cells. The combination of the EGFR inhibitor gefitinib and the mTOR inhibitor everolimus may achieve anti-tumor effect similar to that of single drug by reducing the drug dose.
A social media-based campaign to promote COVID-19 vaccine uptake in underrepresented groups in the US

Problem The COVID-19 pandemic highlighted existing healthcare disparities in the US, with people of color dying from COVID-19 at twice the rate of white people. A striking disparity in vaccination rates for racial minorities followed, with vaccination rates among white people over 2.5 times that for Latinx and nearly twice that for Black people (March 2021). It is vital we ensure tailored public health messaging regarding the COVID-19 vaccine is delivered to all communities. Facebook provides an opportunity for large-scale, targeted health promotion. Description of practice Our goal is to increase COVID-19 vaccination uptake across the US, with a specific focus on reaching underrepresented communities most affected by the pandemic. We created a public health campaign centered on a representative group of physicians conveying their own short ( 50% of the population is Black or Latinx. We launched the campaign in California on April 9, and nationwide on April 12 2021. The primary outcome measures of the campaign were reach (number of individuals exposed, frequency and duration of views) and engagement (number of likes and shares). Results During our campaign (April 9-April 30), the videos appeared on Facebook newsfeeds 54.4 million times, reaching 9.9 million individuals an average of 5.5 times each. Overall, the videos received 10,053 reactions and 1,161 shares. 1.8 million video plays ran for at least 25% of the video. Lessons We demonstrate the feasibility of rapid, social media-based dissemination of tailored public health messages regarding the COVID-19 vaccine to communities in need. We are now focusing efforts on strategies to assess the impact of such messaging on vaccination uptake. Key messages Geotargeting on social media enabled rapid dissemination of COVID-19 vaccine uptake messages to underrepresented communities. Further work is required to evaluate behavioral change impact.
Nutritional and Bioactive Components for Cognitive Development: Special Emphasis on Docosahexaenoic Acid (DHA)

Complete growth and development of various organs and systems and development of cognitive abilities are essential for the health and socio-economic participation of human beings. Nutrition plays a significant role as a non-genetic factor in bestowing physical and mental health to the individuals and this process of attaining nutritional adequacy begins even before the birth of the individual and perhaps even from the time before the conception and pregnancy. Adequate quantitative and qualitative nutrition is essential for overall health status and human productivity. Nutrition also plays a significant role in the development of immunity and conferring resistance to various biotic and environmental stress conditions. Appropriate nutrition can supplement medication in healing and overcoming several diseases and during prophylaxis and aid in the prevention of disease and protection against several noncommunicable and chronic diseases and prevention of allergies.
On commutative Gelfand rings

By studying and using the quasi-pure part concept, we improve some statements and show that some assumptions in some articles are superfluous. We give some characterizations of Gelfand rings. For example: we prove that R is Gelfand if and only if m(sum_{ α \in A} I_ α) = sum_{ α \in A} m ( I_ α ), for each family { I_ α}_{ α \in A} of ideals of R , in addition if R is semiprimitive and Max( R ) ⊆ Y ⊆ Spec( R ), we show that R is a Gelfand ring if and only if Y is normal. We prove that if R is reduced ring, then R is a von Neumann regular ring if and only if Spec( R ) is regular. It has been shown that if R is a Gelfand ring, then Max( R ) is a quotient of Spec( R ), and sometimes h M ( a )’s behave like the zerosets of the space of maximal ideal. Finally, it has been proven that Z Max( C ( X )) = { h_ M ( f ) : f \in C ( X ) } if and only if { h_ M ( f ) : f \in C ( X )} is closed under countable intersection if and only if X is pseudocompact.
Role of Nanotechnology and Nanomaterials for Water Treatment and Environmental Remediation

Nanotechnology has an impact on many scientific and technical fields, including environmental safety. Environmental applications of nanotechnology include water and wastewater treatment, in which different nanomaterials utilize adsorption and separation processes, as well as a variety of other approaches, to remove pollutants, pathogens, and other hazardous elements. Diverse forms, various composites, and active component functionalization are only a few of the ways nanomaterials are formed. To ensure a plentiful supply of water, nanostructures have presented a practical alternative. Due to its very specific area of surface, microinterface properties, and remediation potential, nanomaterials have emerged as a hot topic in environmental research. The review paper covers diverse treatment methods for wastewater, including adsorption, catalysis, spacing, and disinfection, and a range of nanomaterials such as NPs for graphene, TiO 2 nanoparticles (NPs), (nZVI), NPs for nanoscale Fe 3 O 4 , ZnO NPs, nanoparticles in silver (Ag-NPs), Carbon nanotubes (CNTs), and several additional NPs as well as various nanocomposite materials, such as inorganic and organic supports, magnetic nanocomposite, and nanocomposite membranes, etc. Most crucially, the possible application of nanomaterials in water and wastewater treatment is also considered in the future
Fodder productivity of meadow clover varieties depending on the growing technology

The research results for 2018–2020 on the formation of fodder productivity of the yield of the dry mass of different varieties of meadow clover from 1 ha depending on the sowing methods on different backgrounds of fertilizer on typical low-humus chernozems of the Forest-Steppe of Ukraine were presented. On average, for the first three years of growth and use, meadow clover provided productivity of yield of the dry mass of 8.22–9.88 tons from 1 ha, which depended little on sowing methods. Productivity increased by 8–12 % when inoculating seed with nodule bacteria combined with the application of N60P60K90 compared with the variant without fertilizers and only by 4–6 % under separate application of fertilizers (Р60K90 or N60P60K90) or seeds inoculation on the background without fertilizers. The application of N60 on the background of Р60K90 provided the highest payback of 1 kg of fertilizer (6–7 kg of dry mass) among fertilizers. In the first year, sowing under cover of spring barley provided higher productivity by 22–25 %, and in the second and third years, coverless sowing was provided by 7–10 %. The most productive variety was Taifun, which was 0.10–0.66 t/ha of dry mass superior to Lybid and Tina varieties. The factor of fertilization was the most influential in yield of dry mass from 1 ha and the sowing method with a share proportion of 55 % in the first year. Meadow clover annually provided three mowings of fodder biomass with the share of the first mowing of 44–50 %, the second – 32–34 %, and the third – 18–24 %, and the uneven distribution of the yield by mowing by 30–47 %.
Components Removal in Multi Stages' Single-cell Flotation Deinking

In addition to ink removal,valuable materials,such as fibers and minerals will be lost in flotation deinking,which lowers yield and thus decreases the profitability of the process.The removal or loss of ink,ash,long and short fibers and fiber fines from multi stages' single-cell flotation was introduced in this paper.The effect of operational parameters,such as rotor speed,soap addition and flotation consistency on the removal selectivity of each component was also discussed.The results showed that the removal selectivity of ink is very good,and by adding soap just before flotation,the removal selectivity even can be improved.The removal selectivity of ash,long and short fibers and fiber fines is considerably lower than that of ink.The flotation yield reduction is mainly caused by the loss of ash and fiber fines.The ash removal selectivity is practically independent of the rotor speed or soap addition.But increasing pulp consistency will increase the removal of ash.The removal of fiber fines will be related to the decreasing of rotor speed and increasing of pulp consistency.
Game Edukasi Pengenalan Sistem Isyarat Bahasa Indonesia (SIBI) Menggunakan Myo Armband pada Arsitektur Client Server

<p class="Abstrak">Komunikasi verbal adalah komunikasi umum digunakan sebagai sarana dalam memberikan informasi kepada orang lain. Disamping itu, untuk berkomunikasi dengan tuna rungu serta tuna wicara sarana komunikasi dapat melalui bahasa isyarat. Indonesia telah memiliki sistem bahasa isyarat yaitu Bahasa Isyarat Indonesia atau Sistim Isyarat Bahasa Indonesia (SIBI). Aplikasi pengenalan dan pembelajaran SIBI yang ada pada saat ini berupa aplikasi yang terikat pada platform. Aplikasi beserta proses pengenalan menjadi satu sehingga memiliki kebergantungan yang cukup tinggi. Penelitian ini bertujuan mengembangkan platform <em>cloud</em> sebagai <em>backend</em> untuk pengenalan gerakan tangan, sehingga memudahkan pengembang untuk membuat aplikasi pengenalan SIBI. Platform tersebut memiliki kemampuan untuk mengenal gerakan tangan yang diperoleh dari data sensor <em>Myo Armband</em>. Aplikasi yang berada sisi <em>frontend</em> dapat menggunakan fitur platform melalui <em>Application Programming Interface </em>(API) yang disediakan. Penelitian ini juga membangun aplikasi permainan edukasi yang menggunakan platform <em>cloud</em> tersebut sebagai implementasi dari penggunaan platform. Hasil pengujian terhadap platform yang dilakukan menghasilkan kemampuan pengenalan secara <em>real-time</em> dari satu atau lebih client secara simultan. Pada uji 5 client <em>request</em> bersamaan secara simultan, waktu yang dibutuhkan rerata 0.1107333 detik per <em>request</em> pada <em>latency</em> jaringan rerata 36.7 ms. </p><p class="Abstrak"><em><strong>Abstract</strong></em></p><p class="Abstract"><em>Verbal communication is a general communication used in providing information to other people. On the other hand, to communicate with deaf and speech impaired people can use sign language. Indonesia has a sign language system called Indonesian Sign Language or Indonesian Sign Language System (SIBI). The current SIBI introduction and learning application is an application tied to the platform. Application, along with the recognition process, is combined so that it has a high enough dependence. This study aims to develop a cloud platform as a backend for hand gesture recognition, making it easier for developers to create SIBI recognition applications. The platform can recognize hand movements obtained from Myo Armband sensor data. Applications on the front-end side can use the platform features through the provided Application Programming Interface (API). This study also builds an educational game application that uses the cloud platform to implement platform usage. The results of the platform's testing carried out resulted in real-time recognition capabilities from one or more clients simultaneously. In the five simultaneous client requests test, the average time needed is 0.12654 seconds per request at a mean network latency of 36.7 ms.</em></p><p class="Abstrak"><em><strong><br /></strong></em></p><p class="Abstrak" align="center"> </p><p class="Abstrak" align="center"> </p>
A pilot economic evaluation of a feasibility trial for SUpporting wellbeing through PEeR-Befriending (SUPERB) for post-stroke aphasia

Objectives To explore the feasibility of a full economic evaluation of usual care plus peer-befriending versus usual care control, and potential cost-effectiveness of peer-befriending for people with aphasia. To report initial costs, ease of instruments’ completion and overall data completeness. Design Pilot economic evaluation within a feasibility randomised controlled trial Setting Community, England Participants People with post-stroke aphasia and low levels of psychological distress Intervention All participants received usual care; intervention participants received six peer-befriending visits between randomisation and four months Main measures Costs were collected on the stroke-adapted Client Service Receipt Inventory (CSRI) for health, social care and personal out-of-pocket expenditure arising from care for participants and carers at 4- and 10-months post-randomisation. Health gains and costs were reported using the General Health Questionnaire-12 and the EQ-5D-5L. Mean (CI) differences for costs and health gains were reported and uncertainty represented using non-parametric bootstrapping and cost-effectiveness acceptability curves. Results 56 participants were randomised. Mean age was 70.1 (SD 13.4). Most (n = 37, 66%) had mild and many (n = 14; 25%) severe aphasia. There was ≥94% completion of CSRI questions. Peer-befriending was higher in intervention arm (p < 0.01) but there were no significant differences in total costs between trial arms. Peer-befriending visits costed on average £57.24 (including training and supervision costs). The probability of peer-befriending being cost-effective ranged 39% to 66%. Conclusions Economic data can be collected from participants with post-stroke aphasia, indicating a full economic evaluation within a definitive trial is feasible. A larger study is needed to demonstrate further cost-effectiveness of peer-befriending.
Deformation Imaging by Strain in Chronic Heart Failure Over Sacubitril‐Valsartan: A Multicenter Echocardiographic Registry

Sacubitril/valsartan has changed the treatment of heart failure with reduced ejection fraction (HFrEF), due to the positive effects on morbidity and mortality, partly mediated by left ventricular (LV) reverse remodelling (LVRR). The aim of this multicenter study was to identify echocardiographic predictors of LVRR after sacubitril/valsartan administration.
Pengaruh Environmental Knowledge dan Environmental Attitude Terhadap Pro-Environmental Purchasing Behaviour (Sebuah Study Tentang Perilaku Konsumen Gen Z)

Penelitian ini dilakukan untuk menguji pengaruh environmental knowledge, environmental attitude, terhadap pro-environmental purchasing behaviour pada konsumen GenZ. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian deskriptif kuantitatif dan analisis regresi linier terhadap 301 responden yang masuk dalam kategori GenZ (generasi pasca milenial). Temuan penelitian ini yaitu pertama adanya pengaruh yang positif dan signifikan antara Environmental Knowledge (EK) terhadap Pro-environmental purchasing behaviour (PPB), kedua adanya pengaruh yang positif dan signifikan antara Environmental attitude (EA) terhadap Pro-environmental purchasing behaviour (PPB) dan yang ketiga adanya pengaruh yang positif dan signifikan antara environmental knowledge (EK) terhadap environmental Attitude (EA). Temuan selanjutnya menunjukah bahwa media sosial seperti FB, IG, twitter, WA, dll memiliki pengaruh yang besar terhadap pemahaman, sikap dan perilaku remaja yang berdasarkan pada isu-isu lingkungan. Pengetahuan yang memadai tentang isu-isu lingkungan hidup akan membawa dampak positif terhadap kelestarian lingkungan dan keanekaragaman hayati. Penulis menemukan bahwa GenZ bersedia untuk mengkampanyekan program-program pro-lingkungan hidup.Kata Kunci: Konsumsi Berkelanjutan, GenZ, Perilaku Pembelian Pro-Lingkungan, Pengethauan Lingkungan, Sikap Lingkungan. Abstract This study aim to investigate and examine the effect of environmental knowledge and environmental attitudes toward pro-environment buying behavior. The method that used in this research is descriptive quantitative research method and linear regression analysis of 301 respondents who fall into the GenZ category. The findings of this study are first, there is a positive and significant influence between Environmental Knowledge (EK) on Environmental Purchasing Behavior (PPB), second there is a positive and significant influence between Environmental Attitudes (EA) on Environmental Purchasing Behavior (PPB) and third is the influence positive and significant relationship between environmental knowledge (EK) and Environmental Attitude (EA). Further findings show that social media such as FB, IG, twitter, WA, etc. have a great influence on the understanding, attitudes and behavior of young adults based on environmental issues. Sufficient knowledge about environmental issues will have a positive impact on environmental sustainability and biodiversity. In addition, it is also stated, the authors of this research found that GenZ offers to campaign for pro-environmental programs.Keywords: Environmental Knowledge, Environmental Attitudes,Pro-environment Buying Behavior, Sustainable Consumption and GenZ
Review on Power System Out-of-step Separation

In this paper the criteria of out-of-step separation equipment in the current domestic and oversea engineering fields are summarized Based on the analysis of the current designing methods of the out-of-step separations, it is found that the majority of current separation criteria are essentially active power zero-crossing based method. The active power flow in the tie-line between interconnected coherent generators is also likely to be zero-crossing. Hence, it is suggested that all of separation equipment should have the ability of locating the interface (center) of out-of-step correctly. Upgrading the current out-of-step separation equipment into an integrated separation control system using fiber optic communication is one of the major technological trends when seeking a solution for out-of-step control. However, the common features of the interface of out-of step for coordinating the separation equipments based on optical fiber communication system should be found firstly. The key issue of the predictive fast separation scheme is whether it can predict system stability correctly and be applied in the practical field effectively and reliably Finally in the paper, the out-of-step separation of multi-frequency oscillation in a large-scale power system is discussed
Kick Frequency and Velocity Finswimming Analysis In Surface 100 Meter Number Reviewed From Stiffness Monofins Hard and Stiffness Monofins Exstra Hard Characteristics

Finswimming is a water sport that is done using assistive devices, such as bins, monofins, and snorkels. The fastest sport that is carried out in the pool is getting more and more enthusiasts and is starting to attract a lot of attention in its activities. The growing development of this sport makes manufacturers of monofins tools increasingly develop the types of stiffness that are presented, including stiffness monofins hard and stiffness monofins extra hard. The purpose of this study was to analyze the kick frequency and velocity in the number 100 Meter surface in terms of the characteristics of the stiffness monofins hard and the stiffness monofins extra hard. This research method is descriptive quantitative with a cross-sectional research design. The population of this research is finswimming athletes in Bandung, purposive sampling technique is used to determine the sample with several criteria. The sample consisted of 16 athletes with the following criteria: (1) Bandung City Finswimming Athletes had practiced monofins for at least three years. (2) had monofins stiffness hard and extra hard. (3) is in the top 20 of the inter-regional championship monofins. The conclusion of this study, the stiffness monofins hard and stiffness monofins extra hard contributed less to the kick frequency, while on the velocity both had an effect and the stiffness monofins hard gave a greater influence with a percentage of 98.3%.
circPTP4A2-miR-330-5p-PDK2 Signaling Facilitates In Vivo Survival of HuMSCs on SF-SIS Scaffolds and Improves the Repair of Damaged Endometrium

Background Human umbilical cord mesenchymal stem cells- (HuMSCs-) based therapy has shown promising results in the treatment of intrauterine adhesions (IUA). In this study, we aimed to construct a HuMSCs-seeded silk fibroin small-intestinal submucosa (SF-SIS) scaffold and evaluate its ability to repair the damaged endometrium in an IUA mouse model. Methods To identify the functional effect of HuMSCs-SF-SIS scaffolds on the repair of damaged endometrium, a mouse IUA model was established. Uterine morphology and fibrosis were evaluated by hematoxylin-eosin staining and Masson staining. CircRNA sequencing, real-time PCR, and RNA fluorescence in situ hybridization were used to screen and verify the potential circRNAs involved in the repair of damaged endometrium by HuMSCs. Real-time integrated cellular measurement of oxygen consumption rate was performed using the Seahorse XF24 Extracellular Flux Analyzer. The potential downstream miRNAs and proteins of circRNAs were analyzed by dual-luciferase reporter assay and western blot. Results HuMSCs-SF-SIS not only increased the number of glands but also reduced the ulcer area in the IUA model. circPTP4A2 was elevated in the HuMSCs seeded on the SF-SIS scaffolds and was targeted by miR-330-5p-PDK2. It also stabilized the mitochondrial metabolism of HuMSCs. Moreover, miR-330-5p was found to inhibit PDK2 expression through the 3′ UTR target region. A rescue experiment further showed that circPTP4A2-miR-330-5p-PDK2 signaling was critical to HuMSCs-SF-SIS in decreasing the fibrosis area and increasing the number of glands in the IUA model. Conclusion We demonstrated that circPTP4A2 was elevated in HuMSCs-seeded on SF-SIS scaffolds and stabilized the mitochondrial metabolism through miR-330-5p-PDK2 signaling, which contributes to endometrial repair progression. These findings demonstrate that HuMSCs-seeded SF-SIS scaffolds have potential for the treatment of IUA.