Miracle-dz/UniFAR-FTUs huggingface dataset:
β-Arrestins1 inhibit autophagy induced by hypoxic injury in human pulmonary artery endothelial cells via Akt/mTOR signaling pathway

Background To investigate the potential effects of β-Arrestins1 on autophagy and apoptosis in human pulmonary artery endothelial cells (hPAECs) under hypoxic stress. Methods The hPAECs were exposed to normoxic condition and hypoxic injury for 24 h, 48 h, and 72 h, respectively. Then, to explore effects of autophagy on hPAECs with hypoxia, cells were administrated with 3-MA (an inhibitor autophagy). β-Arrestins1 was regulated to explore its effects on autophagy and apoptosis of hPAECs. Transwell cell migration assay and scratch assay were performed to detect the migration by light microscope. Then, CCK-8 assay was used to investigate the proliferation of hPAECs. Meanwhile, TUNEL assay served as apoptosis in hPAECs. In addition, Western blotting assay applied to evaluate protein expressions. Results Hypoxia contributed to hyperproliferation, migration apoptosis resistance of hPAECs. Meanwhile, autophagy was increased in hypoxic hPAECs. Excessive proliferation、migration and apoptosis resistance of hPAECs were reversed after inhibition of autophagy. Then, the β-Arrestins1 and VEGFR3 expression levels were decreased in hypoxic conditions. Moreover, the activity of Akt/mTOR signal pathway was restrained after hypoxic injury. At last, β-Arrestins1+/+ repressed the increased autophagy and apoptosis resistance of hPAECs under hypoxia. Conclusions Our study indicated that β-Arrestins1 mediated VEGFR3 reduced excessive autophagy and apoptosis resistance via Akt/mTOR pathway of hPAECs under hypoxia. It may provide a promising therapeutic target for pulmonary artery hypertension (PAH).
Use of Medicinal Plants as Antimicrobial Agents: A Review of the Successes Story

The use of plants as natural alternative medicines dated back to prehistoric period. Different cultures and beliefs in the world have one history or the other of using plant or its derivatives as a remedy for many diseases. Phytomedicine usually have multiple effects on the body either therapeutic or side effects, the former out-weighs the latter. Their actions often go beyond the symptomatic treatment of diseases caused by microorganisms to formulation of products for daily use. Most medicinal plants are rich in secondary metabolites possessing numerous biological activities such as antioxidant, anticancer, antimalarial, antiinflammatory, analgesics antimicrobial, among others. There is still a great interest in medicinal herbs all over world. The main reason for this is that herbs contain compounds of therapeutic efficacy, and they are derived from natural sources which are tolerated to patient’s body physiologies than the synthetic drugs. Though there was an initial decline in use of medicinal plants, yet the last decade has seen resurgence both in the study and use of phytomedicines in treatment of numerous ailments. These benefits derived from medicinal plants especially as antimicrobial agents necessitated the need for this present review.
Designing More Effective Accountability Report Cards

Author(s): Sabbah, Faris M. | Advisor(s): Gifford, Bernard R. | Abstract: The purpose of this study was to identify and design standards and procedures for creating easily interpreted accountability reports cards, consistent with the requirements spelled out in the No Child Left Behind Act of 2001 (NCLB). The use of public report cards was first raised during the debate that took place immediately prior to the passage of the first precursor to NCLB, Elementary and Secondary Education Act of 1965 (ESEA). Robert F. Kennedy, then junior Senator from New York, argued that issues of programmatic integrity, instructional coherence, school performance, learner progress, and educational accountability were too important to leave exclusively to "professional schoolmen. " The first stage of the study began with a representative cross-section of parents, teachers, and school and district administrators being asked to critique current public report cards and identify design elements of an effective prototypical report card. The feedback produced during these exchanges, in conjunction with the use of a variety of empirical research findings on the design of easy-to-read / easy-to-interpret graphics-rich reports, was utilized to design a prototypical report card. Focus group participants partook in two additional cycles of critique and revision to identify effective design/data elements and to make improvements to the devised report. The resulting report card generated by this prototypical design and continuous improvement process is presented, and commented upon. These comments suggest that the art and craft of designing easily interpreted public report cards continues to be a major challenge.
Determinants of Perinatal birth Asphyxia among Newborns in Ethiopia: A Systematic Review and Meta-analysis of Observational Studies Protocol

Background: Birth asphyxia among newborns accounted for nearly fifty percent of neonatal mortality in sub-Saharan African countries. This scenario has been worst in Ethiopia where every two out of three deaths attributed to birth asphyxia among these babies. Moreover, studies conducted in Ethiopia are highly variable and inconclusive to estimate the pooled prevalence and risk factors of birth asphyxia. Objective: This study aims to analyses collectively and systematically the prevalence of birth asphyxia and associated factors among newborns in Ethiopia.Methods: The protocol for this review is registered at PROSPERO with registration number CRD42020158224. A comprehensive online databases (PubMed, HINARI, Scopus, EMBASE, Science direct, and Cochrane library database), Google Scholar, African Journals online, other gray and online repository accessed studies will be searched using different search engines. In addition, maternity & infant care databases uploaded at Ethiopian Health Development Journal and Ethiopian Journal of Health Sciences will be searched until June 30, 2020. Newcastle-Ottawa Quality Assessment Scale (NOS) will be used for critical appraisal of studies. Three reviewers will screen all retrieved articles, conduct data extraction, and then critically appraise all identified studies. All identified observational studies reporting the prevalence of birth asphyxia and associated factors among neonates in Ethiopia will be considered. The analysis of data will be done using STATA 11.0 statistical software. We will demonstrate pooled estimates and determinants of birth asphyxia with effect size and 95% confidence interval. Heterogeneity among the included studies will be assessed through the Cochrane Q-test statistics and I2 test. Publication bias will be checked using funnel plot and egger’s test. Finally, statistical significance level will be declared at a p-value of less than 0.05. Discussion: the result from this systematic review will inform and guide health policy planners to invest limited resources on maternal and neonatal health. Furthermore, it will be a stimulus for future cumulative meta-analysis researchers in developing nations.
Experiential Learning: Critical Reading through Learning by Doing Method in the Context of Teaching EFL among Engineering Students

In this research paper, the author explores the task on critical reading through ‘learning by doing method’ to bring out the ensuing perceptions of the learners in the perspective of teaching of EFL. This research probes mainly on how reading could enable individual interest in critical appreciation of the novel and how experiential learning through ‘learning by doing method’ develops the learners’ skills. Theoretical groundwork for task assignment on the model learning has been demonstrated for the respondents. As this task emphasizes mainly on self learning through learning by doing method, resembles close with the experiential learning technique. This research asserts to be pragmatic, implementing a task based experiential learning English through learning by doing methodology. This task is confined to the critical appreciation of the contemporary novel for the undergraduate engineering students from one of the reputed national institutes of technology in India.
POFA : a potential partial cement replacement material in aerated concrete

The ever popular issue on environmental preservation and sustainability all over the world has lead to innovations of new material using by-products generated from various sectors resulting from never ending researches conducted. In Malaysia, Faculty of Civil Engineering of Universiti Teknologi Malaysia has been conducting researches for more than 14 years in attempt to utilize of palm oil fuel ash (POFA), a local by-product produced abundantly by palm oil mill. Recently attempts have been carried out to incorporate POFA to produce a new type of aerated concrete known as POFA aerated concrete. The objective of this investigation is to study the effects of increasing the levels of palm oil fuel ash (POFA) replacement towards the compressive strength of aerated concrete. Experiments have been conducted by replacing 10%, 20%, 30%, 40% and 50% of POFA by weight of Ordinary Portland Cement. All specimens were tested for the compressive strength at 28 days in accordance to BS1881: Part 116. Findings will be able to reveal the compressive strength performance in aerated concrete when incorporated with various level of POFA quantity as partial cement replacement in aerated concrete.
Utilization of bamboo as a low cost structural material.

The bamboos are very important plants in many parts of Asia and the world. Despite being an easily replenishable material having some noted strengths, bamboo has not been fully utilized as a building material. However with the current rate of consumption of the traditional materials by the building industry, it is anticipated that bamboo will become increasingly important in the near future. Mechanical testing of local species of bamboo is being carried out and a pilot project on cultivation of the various species has been started at Universiti Pertanian Malaysia. This paper presents the work which is being carried out at the University on the utilization of bamboo as a low-cost material of construction.
Projeto de microssensor de fluxo de massa para medicação de velocidade de fluidos

In this paper, the main characteristics and steps for design and simulation of a thermal mass flow microsensor of calorimetric type are described, aiming to measure flow rate and fluid velocity. The device was designed computationally and its applicability evaluated based on the simulation data. The results leaded to conclude that flows speed between 0 and 14 m/s can be measured using the proposed sensor.
Manipulating task constraints to improve tactical knowledge and collective decision-making in rugby union

In team sports such as rugby union, a myriad of decisions and actions occur within the boundaries that compose the performance perceptual- motor workspace. The way that these performance boundaries constrain decision making and action has recently interested researchers and has involved developing an understanding of the concept of constraints. Considering team sports as complex dynamical systems, signifies that they are composed of multiple, independent agents (i.e. individual players) whose interactions are highly integrated. This level of complexity is characterized by the multiple ways that players in a rugby field can interact. It affords the emergence of rich patterns of behaviour, such as rucks, mauls, and collective tactical actions that emerge due to players’ adjustments to dynamically varying competition environments. During performance, the decisions and actions of each player are constrained by multiple causes (e.g. technical and tactical skills, emotional states, plans, thoughts, etc.) that generate multiple effects (e.g. to run or pass, to move forward to tackle or maintain position and drive the opponent to the line), a prime feature in a complex systems approach to team games performance (Bar- Yam, 2004).
H19 contributes to aerobic glycolysis, proliferation and immune escape of gastric cancer cells via the miR-519d-3p/LDHA axis

Background Long non-coding RNAs (lncRNAs) have been investigated in multiple human cancers including gastric cancer (GC). Our research aims to explore the role of H19 in aerobic glycolysis, proliferation, and immune escape of GC cells.Methods The expression of H19 in GC samples were analyzed using Gene Expression Profiling Interactive Analysis (GEPIA), Gene Expression Omnibus (GEO) data, and real-time quantitative polymerase chain reaction (RT-qPCR) analysis. Glucose consumption and lactate production were applied to assess the aerobic glycolysis of GC cells. Subcellular fractionation, luciferase reporter, and western blot assays certified the binding between genes. CCK-8 and colony formation assays were used to determine GC cell proliferation. Flow cytometry, ELISA, and RT-qPCR assays were applied to analyze the immunosuppressive effect of H19. Results H19 was highly expressed in samples of patients with GC, and associated with tumor growth in vivo. H19 knockdown suppressed glucose consumption, lactate production, proliferation of GC cells by regulating miR-519d-3p/LDHA axis. Both miR-519d-3p depletion and LDHA overexpression could reverse the H19 knockdown-induced decrease in aerobic glycolysis and proliferation. Moreover, conditioned medium (CM) from stable knockdown H19 GC cells modulated the activity of immune cells including γδT cells, Jurkat cells, and tumor-associated macrophages (TAMs) in a lactate dependent manner.Conclusions The H19/miR-519d-3p/LDHA axis mainly contributed to aerobic glycolysis, proliferation, and immune escape of GC cells.
Häststallinredning och djurskyddslagstiftningen

This study describes and reviews horse stable equipment from companies who builds and sells the equipment. In the study the companies various equipment was compared with regulations in the law of prevention of cruelty to animals. The purpose with this study was to find out if the companies stable equipment are approved according to the regulations within this area. The study used at five randomly picked companies. This study showed that three of the five examined companies refered, in one way or another, to the law of prevention of cruelty to animals on their website. Unfortunately not any of the companies referred to todays existing law of prevention of cruelty to animals. Only three of the five companies distributed information about their sizes of boxes, but only two of those builds boxes who are big enough according to the law of prevention of cruelty to animals. Two of the five companies mentioned that they have tried to eliminate the risk of injury to the horse when they designed och built the stable equipment. None of the five examined companies had various dimensions of the bars to the different sizes of horses. The companies also did not write on their website that various sizes of horses need various sizes of boxes. All of the companies neglected to describe the horse's natural behaviour and needs. The result turned out to be that only two of the five examined companies were approved in this study. The conclusion of the study is that the companies who builds and sells horse stable equipment should become a lot better on providing information about for example their sizes of boxes on their website. They should explain to the customer that there are rules about the dimensions dependent on which size of the horse is going to live there. They could inform their customers about todays existing law of prevention of cruelty to animals, instead of confusing the customers with old laws. In some of the cases the companies themselves should read what it says in these directions.
The Unified Process Construction Phase

From the Publisher: AUTHORBIO: Scott W. Ambler started developing software in the early 80s, and has worked in object-oriented development for the past ten years in an array of roles. He is presently engaged as a software process mentor with AmbySoft Inc., a contributing editor with Software Development magazine, and as a columnist for Computing Canada. His previous books include The Object Primer, Building Object Applications That Work, Process Patterns, and More Process Patterns. Larry Constantine has been a pioneer in software development methods for nearly four decades. His interest in figuring out how to do things better quickly led him into management and process issues, with the aim of bridging the divide between the people side and the technology side of software development. Larry has published 14 books and over 150 articles, many of which appear in 'The Peopleware Papers', and in 'Managing Chaos: The Expert Edge in Software Development', which incorporates the best from his popular 'Software Development Management Forum'. He is also a co-author of Jolt award-winning 'Software for Use'. He is a trainer and consultant with clients around the world, as well as a Professor of Computing Science at the University of Technology, Sydney, Australia.
Insights from the Nogales Predator crash for the integration of UAVs into the National Airspace System under FAA interim operational guidance 08-01

In April 2006, an Unmanned Aerial Vehicle (UAV) crashed near Nogales, Arizona. This incident triggered one of the most sustained studies into the causes of failure involving Unmanned Aerial Systems (UAS). The National Transportation Safety Board (NTSB) together with the US Customs and Border Protection (CBP) agency under the Department of Homeland Security identified many lessons from this mishap. The following pages use the insights provided from the Nogales crash to support a critical review of the most recent FAA guidance on the integration of UAS into the U. S. National Airspace System. The existing version of FAA’s Interim Operational Approval Guidance 08-01 addresses many of the problems identified in the NTSB report into this incident. However, we conclude that greater oversight is needed to support the exemptions that are permitted for the provisions within this document. In particular, our analysis questions whether a process that enables the same agency to act as regulator and operator of a UAV can be justified within the National Airspace System especially when Federal Agencies delegate operational responsibility to sub-contractors. It is also argued that the Nogales crash illustrates the need for greater coordination between UAS operational staff and Air Traffic Management in order to improve mutual situation awareness under normal operations but also to support coordination under degraded modes. Finally, it is argued that the existing requirements for the certification of maintenance technicians and of maintenance management processes under FAA 08-01 should be strengthened beyond those for conventional aviation to avoid the sense of complacency that undermines the safety of UAV operations within the National Airspace System.
A dissertation exploring the issues surrounding the rapid development of information appliances by designers

added post publication for the purposes of submission as part of a PhD by published works) This paper examines the ways in which the three dimensional design and world views of the industrial designer can be utilised within a two dimensional interactive space through the use of spatial analogies. The paper begins by examining current approaches before presenting a case study based on the implementation of a Virtual Learning Environment (VLE) called the Virtual School. The Virtual School makes use of spatial analogies, sound and graphic output to support student learning and improve engagement. It also shortens the “learning curve” for new students by making the real and VLE worlds mutually enforcing. The paper concludes by speculating on possible future developments. Designing a Learning Environment for Three Dimensional Thinkers S. Gill & T. Coward Designing a Learning Environment for Three Dimensional Thinkers Steve Gill, Course Director, BA (Hons) Industrial Design Tim Coward, Head of School of Art & Design University of Wales Institute, Cardiff Western Avenue Cardiff UK CF5 2YB Tel: +44 (0) 29 2041 6732 Fax: +44 (0) 29 2041 6645 E-mail: sjgill@uwic.ac. uk / tcoward@uwic.ac. uk International symposium on the dimensions of industrial design research May 18-20, 2000 Politecnico di Milano, Italy Page 1 of 27 Designing a Learning Environment for Three Dimensional Thinkers S. Gill & T. Coward
Short-run forecasts of electricity loads and peaks

This paper reports on the design and implementation of a short-run forecasting model of hourly system loads and an evaluation of the forecast performance. The model was applied to historical data for the Puget Sound Power and Light Company, who did a comparative evaluation of various approaches to forecasting hourly loads, for two years in a row. The results of that evaluation are also presented here. The approach is a multiple regression model, one for each hour of the day (with weekends modelled separately), with a dynamic error structure as well as adaptive adjustments to correct for forecast errors of previous hours. The results show that it has performed extremely well in tightly controlled experiments against a wide range of alternative models. Even when the participants were allowed to revise their models after the first year, many of their models were still unable to equal the performance of the authors' models.
DG Allocation in Primary Distribution Systems Considering Loss Reduction

Loss reduction in distribution systems has been a subject of great concern since the evolution of the interconnected power system. In the recent past, with increasing interest in climate change and energy security, renewable energy integration and energy efficiency, including loss reduction, have been considered as twin-pillars of sustainable energy solutions. When renewable energy is integrated by considering loss reduction as an additional goal, it would lead to multi-fold benefits. This chapter presents the application of distributed generation for loss reduction. The two key issues of the most suitable location and appropriate size of distributed generation for loss reduction have been discussed. Analytical expressions have been developed for finding the appropriate size of different types of distributed generations. Methodologies are presented for locating the DG in primary distribution feeders, assuming primary energy resources are evenly distributed along the feeder. The analytical expressions and placement methodologies have been tested in three test distribution systems of varying sizes and complexity. © 2011 by World Scientific Publishing Co. Pte. Ltd. All rights reserved.
Remote Control Station Design and Testing for Tele-Operated Space-Missions

Space environ ment is inherently hostile and dangerous for astronauts. Since extra -vehicu lar activity (EVA ) should be limited or assisted as much as possible, the significant role of robot ic systems is of notable relevance. Tele-navigation of ground rovers in hostile and unknown environments is one of the applicable p roblems for modern planetary exp loration missions. Pilots involved in these missions should be supported with intelligent and adaptive Hu man-Machine Interfaces (HM Is) able to guarantee a high level of situation awareness and an affordable mental workload. This paper aims to illustrate the approach used to design, test and assess a Remote Control Station (RCS) fo r ground missions . The RCS is used to remotely operate a 4-wheel drive scaled vehicle, representing a min i-rover for space exp loration. The complete system includes the control station and the vehicle, all based on off-the-shelf components. The rover is used as a tool to assess operator"s situation awareness provided through the Graphic User Interface (GUI). This research activity is part of the project STEPS - a research project co-financed by Pied mont Region.