Miracle-dz/UniFAR-FTUs huggingface dataset:
IoT Based Home Automation

Internet-of-Things (IoT) being the forked process of internet services and an emerging trend in technology has attracted a rapid attention in the scope of home automation. IoT forms an integral part for smart operation of home, its security and integrity controlled by human/autonomous interfaces. Each sub domain of IoT based home automation itself reflects a potentially vulnerable research area. It is in this interest that this present communication divides the entire zone of IoT based home automation research into specific interconnected research zones based on certain attributes. Each zone forms a node in the Taxonomy Tree which has been generated using Cosine Similarity Function. The prime objective of this study is to provide prospective researchers with node wise first hand collection of published research and relevant statistics, thereby minimizing effective literature survey duration.
In Vitro MRS of Cells Treated with Trastuzumab at 1.5 Tesla

The aim of the study was to investigate the effect of Trastuzumab on the MCF-7 and CRL-2314 breast cancer cell lines. Additionally, an attempt was made to optimize magnetic resonance spectroscopy (MRS) for cell culture studies, with particular emphasis on the impact of treatment with Trastuzumab. The research materials included MCF-7 and CRL-2314 breast cancer cell lines. The study examined the response of these cell lines to treatment with Trastuzumab. The clinical magnetic resonance imaging (MRI) system, OPTIMA MR360 manufactured by GEMS, with a magnetic field induction of 1.5 T, was used. Due to the nature of the tested objects, their size and shape, it was necessary to design and manufacture additional receiving coils. They were used to image the tested cell cultures and record the spectroscopic signal. The spectra obtained by MRS were confirmed by NMR using a 300 MHz NMR Fourier 300 with the TopSpin 3.1 system from Bruker. The designed receiving coils allowed for conducting experiments with the cell lines in a satisfactory manner. These tests would not be possible using factory-delivered coils due to their parameters and the size of the test objects, whose volume did not exceed 1 mL. MRS studies revealed an increase in the metabolite at 1.9 ppm, which indicates the induction of histone acetylation. Changes in histone acetylation play a very important role in both cell development and differentiation processes. The use of Trastuzumab therapy in breast cancer cells increases the levels of acetylated histones. MRS studies and spectra obtained from the 300 MHz NMR system are consistent with the specificity inherent in both systems.
Continuous Locomotion Mode and Task Identification for an Assistive Exoskeleton Based on Neuromuscular–Mechanical Fusion

Human walking parameters exhibit significant variability depending on the terrain, speed, and load. Assistive exoskeletons currently focus on the recognition of locomotion terrain, ignoring the identification of locomotion tasks, which are also essential for control strategies. The aim of this study was to develop an interface for locomotion mode and task identification based on a neuromuscular–mechanical fusion algorithm. The modes of level and incline and tasks of speed and load were explored, and seven able-bodied participants were recruited. A continuous stream of assistive decisions supporting timely exoskeleton control was achieved according to the classification of locomotion. We investigated the optimal algorithm, feature set, window increment, window length, and robustness for precise identification and synchronization between exoskeleton assistive force and human limb movements (human–machine collaboration). The best recognition results were obtained when using a support vector machine, a root mean square/waveform length/acceleration feature set, a window length of 170, and a window increment of 20. The average identification accuracy reached 98.7% ± 1.3%. These results suggest that the surface electromyography–acceleration can be effectively used for locomotion mode and task identification. This study contributes to the development of locomotion mode and task recognition as well as exoskeleton control for seamless transitions.
EFFECT OF THREE LEVELS OF WATER APPLICATION ON OIL YIELD AND QUALITY FOR AN OLIVE ('PICUAL') ORCHARD

An experiment was carried out to study the effect of three levels of water application on yield and oil quality for an olive ('Picual') orchard, located in the Pencahue Valley, Maule Region of Chile (35°23' S; 71°44' W), during the 2007-2008 growing season. The 8 year-old trees were irrigated by drip irrigation and trained on monocone training system with a planting density of 6×3 m. Levels of water application were: T1 = 100% of the actual evapotranspiration (ETa) between the beginning of massive pit hardening (MPH) and veraison (V); T2 = 60% between MPH and V; and T3 = 30% of ETa during pit hardening and 60% of ETa from the end of pit hardening to V. Fruit yield showed significant differences among treatments where T2 presented the highest yield (15.5 t ha -1 ). However, oil yield was not affected by the levels of water application. Oil yield varied between 2.3 t ha -1 and 2.5 t ha . Also, results indicate that there were not significant differences on oil content, acidity, peroxide number, K 270 , and K 232 . However, the total polyphenols for T2 and T3 were greater than those for T1.
The impact of reservoir scale on amplitude variation with offset

To investigate the vertical and horizontal impact of reservoir scale on the amplitude‐versus‐offset characteristics, we conduct seismic numerical simulations on models containing spatially confined lithologic units with different scales. We find that the reservoir scale has a nonlinear effect on the amplitude‐versus‐offset intercepts and gradients. As the reservoir width increases, amplitude‐versus‐offset intercept and gradient both first increase, then decrease, and finally remain stable. The amplitude‐versus‐offset intercept is maximum when the reservoir width is 80% larger than the Fresnel zone radius, whereas the amplitude‐versus‐offset gradient peaks at 1.5 times the Fresnel zone radius. Both amplitude‐versus‐offset intercept and gradient are approximately proportional to the reservoir width prior to reaching their maxima. When the lateral extent of the reservoir is more than three times the Fresnel zone radius, the amplitude‐versus‐offset attributes are constant. Modelling the reservoir thickness shows that intercept and gradient behave in a manner similar to that of tuning of thin beds. Both the amplitude‐versus‐offset intercept and gradient first increase and then decrease with the thickness, peaking at the tuning thickness. The thickness contribution to amplitude‐versus‐offset variations is negligible when the thickness is larger than 1.6 times of the tuning thickness. Considering the magnitude of the changes in amplitude‐versus‐offset intercept and gradient caused by reservoir scale, the width causes a maximum 433% intercept increase and a 344% gradient increase, whereas the thickness causes a maximum 100% intercept increase and a 73% gradient increase. Cross‐plotting the amplitude‐versus‐offset intercept and gradient shows the reservoir scale change gives rise to an anti‐clockwise spiraling effect. In conclusion, the lateral and vertical extents of the reservoir both play an important role in amplitude variation with offset. Our analysis shows that the lateral reservoir extent has a larger impact on the amplitude variation with offset than the vertical tuning effect.
ISPH Simulation of Scour Behind Seawall Due to Continuous Tsunami Overflow

Tsunami overflow may destroy the coast-protection structures through continuous scour behind them. In this paper, the incompressible smoothed particle hydrodynamics (ISPH) method [Gotoh, H. , Khayyer, A. , Ikari, H. , Arikawa, T. & Shimosako, K. [2014] “On enhancement of incompressible SPH method for simulation of violent sloshing flows,” Appl. Ocean Res. 46, 104–115. ] is modified for simulation of erosion process behind the seawall under continuous tsunami overflow. Concepts of numerical turbid water particle (TWP) and clear water particle (CWP) are proposed to deal with the sediment-entrained flow. Reasonable value of 1250 kg/m3 is suggested for the initial density of the TWPs based on studies of bottom sediment movement. Sediment particle is judged to initiate its movement if the exerting shear stress exceeds the critical shear stress (CSS) of incipient motion of sediment calculated from a prescribed formula. The numerical results are compared with the data of flume experiment [Arikawa, T. , Ikeda, T. , Kubota, K. [2014] “Experimental study on scour behind seawall due to tsunami overflow,” J. Jpn. Soc. Civil Eng., Ser. B2 (Coastal Eng.) 70 (2), I_926-I_930 (in Japanese). ]. The predicted results of the maximum depth as well as the shape of the scour pit reasonably agree with the experimental data.
Expanding the Breadth of Ability in Artificial Intelligence Systems with Decision Trees

This paper introduces a unique perspective. Rather than focusing on improving the already significant achievements of existing artificial intelligence algorithms, it investigates the potential of merging various algorithms to enhance their overall capabilities. Essential design aspects required for this integration are examined, and a prototype system is developed to demonstrate the practical application of these design principles. This method aims to broaden the range of capabilities accessible to a system, addressing the limitation of the narrow focus prevalent in contemporary artificial intelligence.
Effects of neoadjuvant zoledronate and radiation therapy on cell survival, cell cycle distribution, and clinical status in canine osteosarcoma

Introduction Zoledronic acid (ZOL) is a third-generation bisphosphonate with a higher affinity for bone resorption areas than earlier bisphosphonates (i.e., pamidronate, PAM). In human medicine, ZOL provides improved bone pain relief and prolonged time to skeletal-related events compared to its older generational counterparts. Preclinical studies have investigated its role as an anti-neoplastic agent, both independently and synergistically, with radiation therapy (RT). ZOL and RT act synergistically in several neoplastic human cell lines: prostate, breast, osteosarcoma, and fibrosarcoma. However, the exact mechanism of ZOL’s radiosensitization has not been fully elucidated. Methods We investigated ZOL’s ability to induce apoptosis in canine osteosarcoma cell lines treated with various doses of megavoltage external beam radiotherapy. Second, we evaluated cell cycle arrest in ZOL-treated cells to assess several neo-adjuvant time points. Finally, we treated 20 dogs with naturally occurring appendicular OS with 0.1 mg/kg ZOL IV 24 h before receiving 8 Gy of RT (once weekly fraction x 4 weeks). Results We found that apoptosis was increased in all ZOL-treated cell lines compared to controls, and the combination of ZOL and RT resulted in dissimilar apoptosis between Abrams and D-17 and HMPOS cell lines. Cell cycle arrest (G2/M phase) was minimal and variable between cell lines but perhaps greatest at 48 h post-ZOL treatment. Only 10% of dogs treated with ZOL and RT developed pathologic fractures, compared to 44% of dogs historically treated with PAM and RT (p = 0.027). Discussion ZOL and RT appear to be a well-tolerated combination treatment scheme for non-surgical candidates; future studies must elucidate the ideal timing of ZOL.
The Best Current Research on Patellar Tendinopathy: A Review of Published Meta-Analyses

Patellar tendinopathy is a frequent overuse injury in sports that can cause significant pain and disability. It requires evidence-based guidelines on effective prevention and management. However, optimal treatments remain uncertain. We aimed to analyze available meta-analyses to summarize treatment recommendations, compare therapeutic modalities, examine included trials, and offer methodological suggestions to improve future systematic reviews. Meta-analyses were systematically searched for in PubMed (PROSPERO: CRD42023457963). A total of 21 meta-analyses were included. The AMSTAR-2 scale assessed study quality, which was low, with only 23.8% of the meta-analyses being of moderate quality, and none were considered to be of high quality. Heterogeneous outcomes are reported. Multiple platelet-rich plasma (PRP) injections appear superior to eccentric exercises and provide lasting improvements compared to eccentric exercises when conservative treatments fail. Extracorporeal shockwave therapy (ESWT) also seems superior to non-operative options and similar to surgery for patellar tendinopathy in the long term. However, evidence for eccentric exercise efficacy remains unclear due to inconclusive findings. Preliminary findings also emerged for genetic risk factors and diagnostic methods but require further confirmation. This review reveals a lack of high-quality evidence on optimal patellar tendinopathy treatments. While PRP and ESWT show promise, limitations persist. Further rigorous meta-analyses and trials are needed to strengthen the evidence base and guide clinical practice. Methodological enhancements are proposed to improve future meta-analyses.
The socioeconomic burden of spinal muscular atrophy in Saudi Arabia: a cross-sectional pilot study

Background Spinal muscular atrophy (SMA) is a rare debilitating condition with a significant burden for patients and society. However, little is known about how it affects Saudi Arabia's population. The socioeconomic and medical characteristics of affected SMA patients and their caregivers are lacking. Purpose This study aimed to describe the socioeconomic and medical characteristics of SMA patients and caregivers in Saudi Arabia. Patients and methods A cross-sectional questionnaire-based study was conducted using snowball sampling. Assessment tools including EuroQol (EQ-5D-5L) and visual analog scale (EQ-VAS), Generalized Anxiety Disorder 7-item (GAD-7), Patient Health Questionnaire (PHQ-9), and Costs for Patients Questionnaire (CoPaQ) were used to assess the quality of life (QoL), anxiety, depression, and out-of-pocket expenditures. Results Sixty-four caregivers of SMA patients participated. Type I patients had higher sibling concordance, ICU hospitalization, and mechanical support needs. Type III patients had better QoL. Type I patients' caregivers had higher depression scores. Type III patients' caregivers had higher out-of-pocket expenditures. Forty-eight percent received supportive care, while others received SMA approved therapies. Conclusion SMA imposes a significant socioeconomic burden on patients and caregivers, requiring more attention from the healthcare system. Access to innovative therapies varied across SMA types. Pre-marital screening and early detection are crucial to reduce disease incidence and ensure timely treatment.
Risk Factors and Management of Intraocular Pressure Elevation After Vitrectomy Combined with Silicone Oil Tamponade

Abstract Silicone oil has emerged as the common option for intraocular tamponade during complicated retina vitrectomy. However, the postoperative elevation of intraocular pressure (IOP), influenced by numerous factors, remains a significant and frequently encountered complication that poses a potential threat to vision. Extensive research has been conducted to investigate the risk factors associated with elevated IOP following silicone oil tamponade, including silicone oil viscosity, preoperative high IOP, diabetes, and lens status. This comprehensive review aims to gather and summarize the current research findings regarding the risk factors contributing to IOP elevation following silicone oil tamponade, as well as the optimal management strategies for secondary glaucoma. The analysis includes the physicochemical properties of silicone oil, preoperative and intraoperative risk factors, and the effective management of secondary glaucoma. Enhancing our understanding of the primary factors associated with silicone oil-induced IOP elevation will facilitate the guidance of timely and appropriate interventions.
Spectral Data Processing for Field-Scale Soil Organic Carbon Monitoring

Carbon sequestration in soils under agricultural use can contribute to climate change mitigation. Spatial–temporal soil organic carbon (SOC) monitoring requires more efficient data acquisition. This study aims to evaluate the potential of spectral on-the-go proximal measurements to serve these needs. The study was conducted as a long-term field experiment. SOC values ranged between 14 and 25 g kg−1 due to different fertilization treatments. Partial least squares regression models were built based on the spectral laboratory and field data collected with two spectrometers (site-specific and on-the-go). Correction of the field data based on the laboratory data was done by testing linear transformation, piecewise direct standardization, and external parameter orthogonalization (EPO). Different preprocessing methods were applied to extract the best possible information content from the sensor signal. The models were then thoroughly interpreted concerning spectral wavelength importance using regression coefficients and variable importance in projection scores. The detailed wavelength importance analysis disclosed the challenge of using soil spectroscopy for SOC monitoring. The use of different spectrometers under varying soil conditions revealed shifts in wavelength importance. Still, our findings on the use of on-the-go spectroscopy for spatial–temporal SOC monitoring are promising.
Modelling User Perception of Online Visualisation in Real Estate Marketplaces

Increased internet penetration rate has made internet marketing an integral part of real estate industry. This may result in an inefficient process for the buyers and sellers due to the need for physical inspection. The aim of this study is to present key factors influencing the users’ decision to use a web-based technology for real estate purposes. This is an ongoing study including two phases: developing a framework based on a case study, and conducting a survey to measure customer perception on incorporating online visualization techniques. The paper presents the result of the first phase evaluating real estate marketing platforms as case studies in Pakistan and Australia. While the initial results show that physical inspections are still required before deciding on property transaction, it was found that the number of inspections can be reduced by incorporating a 3D model of the property to the listing platform. In addition, it was observed that clarity of search results and provision of a 3D model are some of the key factors influencing the user preference to use the website again. This reinforces the idea that advanced visualization techniques can improve the current reliability issues faced by customers and may also streamline the transactions. This study will be extended by conducting the designed survey in two target countries one a developed country and the other one a developing country to compare the most popular features to international customers.
Alterations in anthropometric, inflammatory and mental health parameters during Ramadan intermittent fasting in a group of healthy people: a prospective cohort study

Fasting has been practiced with different time span in different areas of the world and for various reasons. One of the types of fasting regimens is Ramadan intermittent fasting (RIF), which is described as intermittent dry fasting and known as the most commonly practiced form of religious fasting. Different studies have shown its effects on body composition parameters and mental health, fatigue and quality of life (QoL). Elucidating the relationship of RIF on biological parameters would also be of importance to show its mechanism. Therefore, we evaluated several biological mediators related to mental health, such as ß-nerve growth factor (ß-NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and insulin-like growth factor-1 (IGF-1), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), and matrix-metalloproteinase-9 (MMP-9). This study consisted of fasting (FG; n = 25) and non-fasting group (NFG; n = 25). Four different time points were assessed for FG: one week before (T1), mid (T2), last days (T3), and one week after (T4) RIF. T1 and T3 were the assessment time points for NFG. Biological mediators were determined from serum samples by using Human Magnetic Luminex and enzyme-linked immunosorbent assay. Furthermore, we then performed correlation analyses between biological mediators and our previously published clinical parameters including body composition and mental health parameters at all time points. Significant alterations were shown in FG for ß-NGF (T2vsT3, p < 0.05; T2vsT4, p < 0.05), GDNF (T1vsT4, p < 0.05; T2vsT4, p < 0.05), IL-8 (T2vsT3, p < 0.05; T3vsT4, p < 0.05), TNF-α (T1vsT3, p < 0.05; T1vsT4, p < 0.001; T2vsT4, p < 0.001), and MMP-9 (T1vsT4, p < 0.01). There were no statistically significant differences between FG and NFG in all biological mediators at T1 and T3. Correlation analysis showed that MMP-9 levels had negative correlation with body mass index (BMI) at T3. At T3 BDNF levels had negative correlation with Epworth Sleepiness Scale (ESS) as one of measured QoL parameters. ß-NGF, GDNF, TNF-α, and MMP-9 had positive correlation with some of body composition and mental health parameters. Findings demonstrate that RIF altered different biological mediators could give benefit to health. Its benefit is mediated by the alteration of biological mediators.
Penisimplicins A and B: Novel Polyketide–Peptide Hybrid Alkaloids from the Fungus Penicillium simplicissimum JXCC5

In this study, two previously undescribed nitrogen-containing compounds, penisimplicins A (1) and B (2), were isolated from Penicillium simplicissimum JXCC5. The structures of 1 and 2 were elucidated on the basis of comprehensive spectroscopic data analysis, including 1D and 2D NMR and HRESIMS data. The absolute configuration of 2 was determined by Marfey’s method, ECD calculation, and DP4+ analysis. Both structures of 1 and 2 feature an unprecedented manner of amino acid-derivatives attaching to a polyketide moiety by C-C bond. The postulated biosynthetic pathways for 1 and 2 were discussed. Additionally, compound 1 exhibited significant acetylcholinesterase inhibitory activity, with IC50 values of 6.35 μM.