Miracle-dz/UniFAR-FTUs huggingface dataset:
Determination of the refractive indices of AlN, GaN, and AlxGa1−xN grown on (111)Si substrates

The refractive indices of several AlxGa1−xN alloys deposited on silicon are determined by ellipsometry and reflectivity experiments at room temperature. The AlGaN layers are grown on (111)Si substrate by molecular-beam epitaxy on top of an AlN/GaN/AlN buffer in order to reduce the strain of the alloy. The Al composition is deduced from energy dispersive x-ray spectroscopy and photoluminescence experiments. The refractive index n and the extinction coefficient k are determined in the 300–600 nm range. For the transparent region of AlxGa1−xN, the refractive index is given in form of a Sellmeier law.
Anthropometric and Physiological Profiles of Hungarian Youth Male Soccer Players of Varying Ages and Playing Positions: A Multidimensional Assessment with a Critical Approach

Background: This study aimed to create preliminary anthropometric and physiological profiles of Hungarian male soccer players belonging to different age categories (14, 15, 16, and 17–18-years) and assigned to different playing positions (forward, defender, midfielder, goalkeeper). Methods: Anthropometric and physiological profiles were created for four age groups: 14- (n = 20), 15- (n = 16), 16- (n = 22) and 17–18-year-olds (n = 23) representing the Hungarian soccer academy. Additionally, the variables were analyzed across the four player positions mentioned above. Results: The mean values of body mass, fat mass and BMI were within normal limits, although in some cases the anthropometric and body composition values were too high, particularly among the 17–18-year-olds. The mean values of HRrest were lowest among the 15-year-olds. The highest mean and maximal values of rVO2max and rVO2/AT [57.6 ± 8.12 (43.8–68.3) and 51.2 ± 7.24 (38.9–60.8) mL/kg/min, respectively] were noted in 14-year-olds. Goalkeepers performed significantly better than the remaining soccer players in terms of the most anthropometric and physiological characteristics, except for the Yo-Yo test (p < 0.001). Conclusions: The values of anthropometric parameters increased with age. As expected, the oldest group achieved the best results in the performance tests. Goalkeepers outperformed the players representing other playing positions in the tests when assessing lower limb strength, sprint performance (5- and 10-m distance), and agility tests. From a practical point of view, the presented anthropometric and physiological profiles of players representing different age groups and playing positions can be useful for soccer coaches, strength and conditioning specialists, and athletic trainers of other soccer clubs in terms of the individualization and optimalization of soccer training.
Circumfixes as emergent linguistic structures

One of the manifestations of linguistic complexity is what Dahl (2004:2) describes as ‘grammatical constructions whose expression is longer than apparently necessary from a cross-linguistic perspective’. In the morphological system of Nguni languages there is a range of co-occurring affixes in both the nominal and the verbal morphological systems that seem to be unnecessary from a cross-linguistic comparison of Bantu languages in southern Africa. The relations between these co-occurring prefix and suffix pairs have not been accounted for in the traditional descriptive grammars of these languages despite the fact that their correlations are quite obvious. For the purpose of the development of morphosyntactic tags for the Nguni languages, we treated such affix pairs as discontinuous morphemes, that is, circumfixes. In this article, we would like to show that the circumfixes of the Nguni languages are typical emergent phenomena in that they ‘arose unexpectedly’ given comparable expressions in the other southern African Bantu languages, and in that they have a ‘natural origin’ from a cross-linguistic perspective. Put differently, they are the result of what Dahl (2004:27) calls ‘a symmetric mutual attunement’ of elements from similar expressions in other Bantu languages and perhaps even other African languages.
The global landscape of approved antibody therapies

Abstract Antibody therapies have become an important class of therapeutics in recent years as they have exhibited outstanding efficacy and safety in the treatment of several major diseases including cancers, immune-related diseases, infectious disease and hematological disease. There has been significant progress in the global research and development landscape of antibody therapies in the past decade. In this review, we have collected available data from the Umabs Antibody Therapies Database (Umabs-DB, https://umabs.com) as of 30 June 2022. The Umabs-DB shows that 162 antibody therapies have been approved by at least one regulatory agency in the world, including 122 approvals in the US, followed by 114 in Europe, 82 in Japan and 73 in China, whereas biosimilar, diagnostic and veterinary antibodies are not included in our statistics. Although the US and Europe have been at the leading position for decades, rapid advancement has been witnessed in Japan and China in the past decade. The approved antibody therapies include 115 canonical antibodies, 14 antibody-drug conjugates, 7 bispecific antibodies, 8 antibody fragments, 3 radiolabeled antibodies, 1 antibody-conjugate immunotoxin, 2 immunoconjugates and 12 Fc-Fusion proteins. They have been developed against 91 drug targets, of which PD-1 is the most popular, with 14 approved antibody-based blockades for cancer treatment in the world. This review outlined the global landscape of the approved antibody therapies with respect to the regulation agencies, therapeutic targets and indications, aiming to provide an insight into the trends of the global development of antibody therapies.
Radiomics as an emerging tool in the management of brain metastases

Abstract Brain metastases (BM) are associated with significant morbidity and mortality in patients with advanced cancer. Despite significant advances in surgical, radiation, and systemic therapy in recent years, the median overall survival of patients with BM is less than 1 year. The acquisition of medical images, such as computed tomography (CT) and magnetic resonance imaging (MRI), is critical for the diagnosis and stratification of patients to appropriate treatments. Radiomic analyses have the potential to improve the standard of care for patients with BM by applying artificial intelligence (AI) with already acquired medical images to predict clinical outcomes and direct the personalized care of BM patients. Herein, we outline the existing literature applying radiomics for the clinical management of BM. This includes predicting patient response to radiotherapy and identifying radiation necrosis, performing virtual biopsies to predict tumor mutation status, and determining the cancer of origin in brain tumors identified via imaging. With further development, radiomics has the potential to aid in BM patient stratification while circumventing the need for invasive tissue sampling, particularly for patients not eligible for surgical resection.
Iterative subspace correction methods for thin elastic structures and Korn's type inequality in subspaces

We present a methodology for the efficient solution of three–dimensional problems for thin elastic structures, such as shells, plates, rods, arches and beams, based on the synergy of two fundamental concepts: the subspace correction and the Korn's type inequality in subspaces. The former provides the theoretical background which enables the development of modern iterative methods for large–scale problems, such as domain decomposition and multilevel methods, which are sine qua non for high–performance scientific and engineering computing, and the latter is responsible for the design of iterative methods for thin elastic structures with convergence which is uniform with respect to the thickness. The subspace correction methods are based on the decomposition of the space where the solution is sought into the sum of subspaces. In this paper we show that using the Korn's type inequality in subspaces we can introduce subspace decompositions for which the convergence rate of the corresponding subspace correction methods is independent of both the thickness and the discretization parameters.
Curcumin-Loaded Microspheres Are Effective in Preventing Oxidative Stress and Intestinal Inflammatory Abnormalities in Experimental Ulcerative Colitis in Rats

Curcumin’s role in the treatment of ulcerative colitis (UC) has been proven by numerous studies, but its preventive administration, with the aim of reducing the remission episodes that are characteristic of this disease, must be further investigated. This study investigates the effects of a novel curcumin-loaded polymeric microparticulate oral-drug-delivery system for colon targeting (Col-CUR-MPs) in an experimental model of UC. Male Wistar rats (n = 40) were divided into five groups (n = 8), which were treated daily by oral gavage for seven days with a 2% aqueous solution of carboxymethylcellulose sodium salt (CMCNa) (healthy and disease control), free curcumin powder (reference), Col-CUR-MPs (test) and prednisolone (reference) prior to UC induction by the intrarectal administration of acetic acid (AA), followed by animal sacrification and blood and colonic samples’ collection on the eighth day. Col-CUR-MPs exhibited an important preventive effect in the severity degree of oxidative stress that resulted following AA intrarectal administration, which was proved by the highest catalase (CAT) and total antioxidant capacity (TAC) levels and the lowest nitrites/nitrates (NOx), total oxidative status (TOS) and oxidative stress index (OSI) levels. Biochemical parameter analysis was supported by histopathological assessment, confirming the significant anti-inflammatory and antioxidant effects of this novel colon-specific delivery system in AA-induced rat models of UC. Thus, this study offers encouraging perspectives regarding the preventive administration of curcumin in the form of a drug delivery system for colon targeting.
The Financial Situation of Microsoft and Designed Binary Option

Microsoft is an American multinational technology company that attracts a lot of attention from investors. This report provides effective information for investors by analyzing its financial data, making forecasts and evaluations. This study analyzed Microsoft's financial performance, stock price change, and standard & Poor's constant. At the same time, a special option, binary option, is introduced. Furthermore, the influence of sensitivity analysis on price and volatility is also introduced. MSFT trades at around $220 to $290 a month, giving it a return of close to 0.1% to 6%. According to the sensitivity analysis with the market price as the variable, when the market price rises, the call option's value will gradually approach $20. On the contrary, the value of the call option will gradually decrease with the market price decline. In addition, when the market price rises by $1, the value of the call option will rise by $0.1027, in the process showing that there is a positive correlation between the market price and the value of the call option in this case.
Midfrontal Theta Activity Is Sensitive to Approach–Avoidance Conflict

Midfrontal theta (FMθ) in the human EEG is commonly viewed as a generic and homogeneous mechanism of cognitive control in general and conflict processing in particular. However, the role of FMθ in approach–avoidance conflicts and its cross-task relationship to simpler stimulus-response conflicts remain to be examined more closely. Therefore, we recorded EEG data while 59 healthy participants (49 female, 10 male) completed both an approach–avoidance task and a flanker task. Participants showed significant increases in FMθ power in response to conflicts in both tasks. To our knowledge, this is the first study to show a direct relationship between FMθ and approach–avoidance conflicts. Crucially, FMθ activity was task dependent and showed no cross-task correlation. To assess the possibility of multiple FMθ sources, we applied source separation [generalized eigendecomposition (GED)] to distinguish independent FMθ generators. The activity of the components showed a similar pattern and was again task specific. However, our results did not yield a clear differentiation between task-specific FMθ sources for each of the participants. Overall, our results show FMθ increases in approach–avoidance conflicts, as has been established only for more simple response conflict paradigms so far. The independence of task-specific FMθ increases suggests differential sensitivity of FMθ to different forms of behavioral conflict. SIGNIFICANCE STATEMENT FMθ is well established as an indicator for cognitive conflict in tasks involving simple stimulus–response conflicts. However, we do not yet know about its role in more complex forms of goal ambivalence, such as approach–avoidance conflicts. Thus, we implemented an approach–avoidance task and a flanker task to investigate FMθ in response to simple as well as more complex response conflicts. To our knowledge, this is the first study to show a direct relationship between FMθ and approach–avoidance conflicts. Although the transient FMθ increase is similar to that induced in a simple response conflict task, individual FMθ responsiveness to these two forms of conflict were independent of each other, suggesting intraindividual differences in the sensitivity of FMθ to different forms of behavioral conflict.
The lepton asymmetry of the universe

The standard hot big bang cosmological model has been extremely successful in explaining the Tγ ≃ 2.7 °K microwave radiation and the relative abundance of primordial helium and deuterium [1]. When combined with the ideas of grand unification [2] it may also give a plausible dynamical explanation of the small baryon asymmetry B ≡ (nB −n B − )/nγ ≃ 10−10±1 observed in the present universe.
The improved dynamic slicing for spectrum-based fault localization

Background Spectrum-based Fault localization have proven to be useful in the process of software testing and debugging. However, how to improve the effectiveness of software fault localization has always been a research hot spot in the field of software engineering. Dynamic slicing can extract program dependencies under certain conditions. Thus, this technology is expected to benefit for locating fault. Methods We propose an improved dynamic slicing for spectrum-based fault localization under a general framework. We first obtain the dynamic slice of program execution. Secondly, we construct a mixed slice spectrum matrix from the dynamic slice of each test case and the corresponding test results. Finally, we compute the suspiciousness value of each statement in the mixed-slice spectram matrix. Results To verify the performance of our method, we conduct an empirical study on 15 widely used open-source programs. Experimental results show that our approach achieves significant improvement than the compared techniques. Conclusions Our approach can reduce approximately 1% to 17.79% of the average cost of code examined significantly.
Proposal for graphene-based coherent buffers and memories

We theoretically report that, at a sharp electrostatic step potential in graphene, massless Dirac fermions can obtain Goos-H\"{a}nchen-like shifts under total internal reflection. Based on these results, we study the coherent propagation of the quasiparticles along a sharp graphene \emph{p-n-p} waveguide and derive novel dispersion relations for the guided modes. Consequently, coherent graphene devices (e.g. movable mirrors, buffers and memories) induced only by the electric field effect can be proposed.
Bile Acids: Major Regulator of the Gut Microbiome

Bile acids are synthesized from cholesterol and play an important role in regulating intestinal microflora. The different degrees of hydrophobicity and acidity of individual bile acids may affect their antimicrobial properties. We examined the antimicrobial effects of different bile acids on various microorganisms in vitro and confirmed whether these remain consistent in vivo. Using human bile acids, including ursodeoxycholic acid, cholic acid, chenodeoxycholic acid, deoxycholic acid, and lithocholic acid, a disc diffusion test was performed, and a rodent model was created to determine the antimicrobial effects of each bile acid. The fecal bacterial population was analyzed using a real-time polymerase chain reaction. Each bile acid showed different microbial inhibitory properties. The inhibitory activity of bile acids against microbiota which normally resides in the gastrointestinal tract and biliary system, was low; however, normal flora of other organs was significantly inhibited. Changes in microbial counts after bile acid administration in a rodent model differed in the colon and cecum. The in vivo and in vitro results show that the antimicrobial effects of bile acids against intestinal microbiota were similar. In conclusion, bile acids could be a novel treatment strategy to regulate gut microbiota.
Classification of the Chiral Z_2 x Z_2 Heterotic String Models

This thesis provides a classification of the chiral content of the heterotic $\mathbbm{Z}_2 \times \mathbbm{Z}_2$ orbifold models. We show that the chiral content of the heterotic $\mathbbm{Z}_2 \times \mathbbm{Z}_2$ orbifold models at any point in the moduli space can be described by a free fermionic model. We present a direct translation between the orbifold formulation and the free fermionic construction. We use the free fermionic description for the classification wherein we consider orbifolds with symmetric shifts. We show that perturbative three generation models are not obtained in the case of $\mathbbm{Z}_2 \times \mathbbm{Z}_2$ orbifolds with symmetric shifts on complex tori, and that the perturbative three generation models in this class necessarily employ an asymmetric shift. We show that the freedom in the modular invariant phases in the $N = 1$ vacua that control the chiral content, can be interpreted as vacuum expectation values of background fields of the underlying $N = 4$ theory, whose dynamical components are projected out by the $\mathbbm{Z}_2$ fermionic projections. In this class of vacua the chiral content of the models is determined by the underlying $N = 4$ mother theory.
Protective Effects of Flavonoids against Alzheimer’s Disease: Pathological Hypothesis, Potential Targets, and Structure–Activity Relationship

Alzheimer’s disease (AD) is a neurodegenerative disease with high morbidity and mortality, for which there is no available cure. Currently, it is generally believed that AD is a disease caused by multiple factors, such as amyloid-beta accumulation, tau protein hyperphosphorylation, oxidative stress, and inflammation. Multitarget prevention and treatment strategies for AD are recommended. Interestingly, naturally occurring dietary flavonoids, a class of polyphenols, have been reported to have multiple biological activities and anti-AD effects in several AD models owing to their antioxidative, anti-inflammatory, and anti-amyloidogenic properties. In this review, we summarize and discuss the existing multiple pathogenic factors of AD. Moreover, we further elaborate on the biological activities of natural flavonoids and their potential mode of action and targets in managing AD by presenting a wide range of experimental evidence. The gathered data indicate that flavonoids can be regarded as prophylactics to slow the advancement of AD or avert its onset. Different flavonoids have different activities and varying levels of activity. Further, this review summarizes the structure–activity relationship of flavonoids based on the existing literature and can provide guidance on the design and selection of flavonoids as anti-AD drugs.
Development of lanthanum chromites-based materials for solid oxide fuel cell interconnects

Lanthanum chromites (LaCrO3) are the main materials used as interconnect for solid oxide fuel cells. However, there are several difficulties involved in the processing of these materials. The objective of this work is to investigate and to characterize the relationships between microstructural development process and the electro-thermal-mechanical behavior of earth-alkaline metals doped lanthanum chromites-based ceramics. Calcium and strontium doped lanthanum chromites-based ceramic powders were produced by solution-based method from respective metallic nitrates. Samples were prepared by pressing and sintering procedures. The phase composition was evaluated by X-ray diffraction and densification level by Archimedes method. The microstructural characterization was made by scanning electron microscopy, energy dispersive X-ray spectroscopy and thermal analysis techniques. Electrical tests were used to evaluate the electrical conductivity of the samples, and thermal expansion coefficient was determined by dilatometric measurements. The obtained experimental results corroborate the literature comments concerning the difficulty of lanthanum chromite-based ceramics with high densification level and evidence the great influence of the nature of the dopants on the sintering mechanism and the microstructural and electric characteristics of the produced ceramics. The best ones results, in terms of densification and homogeneity characteristics, had been gotten through multiple doping with calcium and strontium, and in sintering temperature conditions lower that the normally considered to pure or mono-doped lanthanum chromite-based ceramics.
Welfare of cattle during transport

Abstract In the framework of its Farm to Fork Strategy, the Commission is undertaking a comprehensive evaluation of the animal welfare legislation. The present Opinion deals with protection of cattle (including calves) during transport. Welfare of cattle during transport by road is the main focus, but other means of transport are also covered. Current practices related to transport of cattle during the different stages (preparation, loading/unloading, transit and journey breaks) are described. Overall, 11 welfare consequences were identified as being highly relevant for the welfare of cattle during transport based on severity, duration and frequency of occurrence: group stress, handling stress, heat stress, injuries, motion stress, prolonged hunger, prolonged thirst, respiratory disorders, restriction of movement, resting problems and sensory overstimulation. These welfare consequences and their animal‐based measures are described. A variety of hazards, mainly relating to inexperienced/untrained handlers, inappropriate handling, structural deficiencies of vehicles and facilities, poor driving conditions, unfavourable microclimatic and environmental conditions, and poor husbandry practices leading to these welfare consequences were identified. The Opinion contains general and specific conclusions relating to the different stages of transport for cattle. Recommendations to prevent hazards and to correct or mitigate welfare consequences have been developed. Recommendations were also developed to define quantitative thresholds for microclimatic conditions within the means of transport and spatial thresholds (minimum space allowance). The development of welfare consequences over time was assessed in relation to maximum journey duration. The Opinion covers specific animal transport scenarios identified by the European Commission relating to transport of unweaned calves, cull cows, the export of cattle by livestock vessels, the export of cattle by road, roll‐on‐roll‐off ferries and ‘special health status animals’, and lists welfare concerns associated with these.