Miracle-dz/UniFAR-FTUs huggingface dataset:
Influential Spreaders Identification in Complex Networks With TOPSIS and K-Shell Decomposition

In view that the K-shell decomposition method can only effectively identify a single most influential node, but cannot accurately identify a group of most influential nodes, this article proposes a hybrid method based on K-shell decomposition to identify the most influential spreaders in complex networks. First, the K-shell decomposition method is used to decompose the network, and the network is regarded as a hierarchical structure from the inner core to the periphery core. Second, the existing centrality methods such as H-index are used as the secondary score of the proposed method to select nodes in each hierarchy of the network. In addition, for the sake of alleviating the overlapping problem, the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) method is introduced to calculate the comprehensive score of secondary score and overlapping range, and the node with the highest comprehensive score will be selected in each round. The proposed algorithm can be used as a general framework to improve the existing centrality method which can represent nodes with definite values of centrality. Experimental results show that in the susceptible–infected–recovered (SIR) model experiment, compared with the benchmark methods, the infection scale of the proposed K-TOPSIS method in nine real networks is improved by 1.15%, 2.23%, 1.95%, 3.12%, 6.29%, −0.37%, 4.01%, 0.48%, and 0.48%, respectively. The novel method is improved by 0.44, 1.18, 1.16, 11.30, 2.03, 2.53, 2.70, and 2.13 in average shortest path length experiment, respectively, except for Facebook network. It shows that the novel method is reasonable and effective.
Bioinformatics pipeline to guide late‐onset Alzheimer's disease (LOAD) post‐GWAS studies: Prioritizing transcription regulatory variants within LOAD‐associated regions

As new late‐onset Alzheimer's disease (LOAD) genetic risk loci are identified and brain cell–type specific omics data becomes available, there is an unmet need for a bioinformatics framework to prioritize genes and variants for testing in single‐cell molecular profiling experiments and validation using disease models and gene editing technologies. Prior work has characterized and prioritized active enhancers located in LOAD‐genome‐wide association study (GWAS) regions and their potential interactions with candidate genes. The current study extends this work by focusing on single nucleotide polymorphisms (SNPs) within these LOAD enhancers and their impact on altering transcription factor (TF) binding. The proposed bioinformatics pipeline progresses from SNPs located in LOAD‐GWAS regions to a filtered set of candidate regulatory SNPs that have a predicted strong effect on TF binding.
Socioeconomic Development on Poverty Alleviation of Women Entrepreneurship

Purpose: In many developing and affluent countries, poverty alleviation has been the prime goal of promoting socioeconomic status. The Government's attempt to curb poverty includes promoting monetary-generation projects, providing facilities to raise the standard of living, and executing the programs to teach positive values for these underprivileged. The research seeks to uncover decisive aspects of socioeconomic improvement of poverty alleviation in women entrepreneurship Methodology: Data of 300 women entrepreneurs from three different states in Malaysia participated in the study. We have analyzed the research data through PLS-SEM to examine the formulated hypotheses. Findings: It indicates microfinance was the strongest predictor of poverty alleviation in Malaysia. Entrepreneurial and personality factors are next on the list. Conversely, the environment and culture had little impact on impoverishment Research Implications: The importance acceptance of the microfinance program is the primary catalyst in creating new employment. It also provides a source of earning to improve the underprivilege’s social and economic well-being and eradicate poverty.
Therapeutic Strategies for Patients with Advanced Small Bowel Adenocarcinoma: Current Knowledge and Perspectives

Simple Summary Small bowel adenocarcinomas (SBA) are rare tumors with a poor prognosis. Due to the rareness of this illness, there is limited scientific data to guide therapeutic management. The recent large prospective ARCAD-NADEGE study evaluated 347 patients with SBA and has helped to improve our current knowledge of this disease. When diagnosed with advanced, non-surgically resectable disease, chemotherapy remains the cornerstone of the treatment and appears to add a survival benefit compared to palliative care. Other more recent drugs, such as small molecule targeted therapeutic inhibitors or immunotherapy, may have a role in improving the outcome of patients with advanced SBA. In this review, we summarized the classical therapeutic arsenal as well as possible future promising treatments in advanced SBA. Abstract Small bowel adenocarcinoma (SBA) is diagnosed at an advanced (unresectable or metastatic) tumor stage in approximately one-third of cases. This is partly due to the non-specific symptomatology and limitations in endoscopic and radiologic detection methods. In this context, the prognosis remains poor and systemic chemotherapy appears to benefit patients when compared to best supportive care alone, despite the absence of randomized controlled trials. The results of a recent large prospective cohort (ARCAD-NADEGE) reported that the absence of chemotherapy was a predictive factor for a lower overall survival (OS) even though poor differentiation and SBA associated with Crohn’s disease correlate with poor prognosis. In retrospective series, the median OS ranges from approximately 9 to 18 months with current treatment approaches. A combination of a fluoropyrimidine and oxaliplatin (FOLFOX or CAPOX) appears to be the most utilized and effective first-line chemotherapy regimen. Other front-line alternatives are the combination of 5-FU and cisplatin or fluoropyrimidine and irinotecan (FOLFIRI). In second-line, FOLFIRI is an effective option after progression on platinum-based therapy. Taxane-based therapy appears to be an alternative option, but further evaluation in larger series is needed. To a limited extent, the role of surgical resection for metastatic disease appears to be a valid option, though this approach has not been evaluated in prospective clinical studies. Due to the rareness of the disease, inclusion in clinical trials should be prioritized, and there is hope that targeted therapies and immunotherapy may enter the therapeutic arsenal for these patients.
Successful Silencing of the Mycotoxin Synthesis Gene TRI5 in Fusarium culmorum and Observation of Reduced Virulence in VIGS and SIGS Experiments

Crops constantly experience various biotic stresses during their life cycle, and Fusarium spp. remain one of the most serious groups of pathogens affecting plants. The ability to manipulate the expression of certain microorganism genes via RNAi creates the opportunity for new-generation dsRNA-based preparations to control a large number of diseases. In this study, we applied virus-induced gene silencing (VIGS), and spray-induced gene silencing (SIGS) to silence the trichothecene-producing gene TRI5 in F. culmorum as a means to reduce its aggressiveness on spring wheat. Treatment of the fungus with dsTRI5RNA in vitro reduced deoxynivalenol (DON) and 3-acetyldeoxynivalenol (3-A-DON) accumulations by 53–85% and 61–87%, respectively, and reduced TRI5 expression by 84–97%. VIGS decreased the proportion of infected wheat spikelets by 73%, but upregulation was observed for TRI5. SIGS on wheat leaves and ears using certain dsTRI5RNA amounts negatively impacted F. culmorum growth. However, when performing in vivo analyses of TRI5 mRNA levels, the upregulation of the gene was determined in the variants where fungal colonization was restricted, suggesting a compensatory reaction of the pathogen to RNAi.
A Study on the Factors Contributing to Customer Loyalty in Budget Hotels in Cairo And Alexandria, Egypt

Customer loyalty has gained great consideration in recent years. It is crucial for hotel’s success and survival in this competitive market. This research intends to determine the factors contributing to customer loyalty in budget hotel sector in Egypt. This research was investigated by adopting a quantitative research approach. A structured survey was set up involving 33 items to measure customer loyalty and investigated constructs. The outcomes of this study highlighted low level of customer loyalty in budget hotels in Egypt. Four determinants were identified to have major positive impact on customer loyalty respectively: corporate image, price perception, physical environment and switching costs whereas CSR did not have significant effect on customer loyalty. The research implies that budget hotels’ managers should invest in improving the factors that were identified as influential/supportive to attract and retain customers. They should deal with customer loyalty as a strategic target and maintain a long-term relationship with customers to enhance their repurchasing intentions. This research contributes to boost customer loyalty in the context of budget hotel sector. It provides a range of tools and recommendations that will motivate customers’ re-buying behavior and make them more emotionally-tied to small hospitality organizations.
Potensi Imunomodulator Herbal Ekstrak Etanol Daun Pepaya Varietas Calina terhadap Struktur Jaringan Limpa Tikus Putih Galur Wistar

Tanaman pepaya varietas calina (Carica papaya L. Var. calina) merupakan salah satu jenis tanaman pepaya yang banyak dibudidayakan di Indonesia. Tanaman ini memiliki kandungan senyawa aktif yang dapat berperan dalam meningkatkan kerja imun seperti flavonoid, polifenol, tanin dan saponin. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak etanol daun pepaya varietas calina sebagai imunomodulator alami terhadap struktur jaringan limpa tikus putih galur wistar (Rattus norvegicus Berkenhout, 1769). Penelitian menggunakan 24 ekor tikus wistar yang dibagi ke dalam empat perlakuan pemberian ekstrak yaitu kontrol (dosis 0 mg/kg BB), P1 (dosis 100 mg/kg BB), P2 (dosis 200 mg/kg BB), dan dosis P3 (300 mg/kg BB) selama 30 hari per oral. Parameter yang diamati meliputi bobot badan, rasio bobot limpa dan histologi limpa yang terdiri dari luas dan diameter pulpa putih serta luas germinal center. Tikus dikorbankan nyawanya pada hari ke-31, kemudian organ limpa diambil dan difiksasi dengan neutral buffer formaline 10%. Limpa dibuat sediaan histologis dengan menggunakan blok parafin dan pewarnaan hematoxylin-eosin. Data dianalisis dengan menggunakan sidik ragam satu arah kemudian dilanjutkan uji jarak berganda Duncan untuk mengetahui tingkat signifikansi antar perlakuan. Hasil penelitian menunjukkan bahwa seluruh perlakuan memberikan pengaruh yang signifikan (P<0,05), dalam hal menambah diameter dan memperluas pulpa putih serta memperluas germinal center pada limpa dibandingkan dengan kontrol. Bobot badan dan rasio organ limpa tidak menunjukan perbedaan secara siginifikan antar perlakuan (P>0,05). Simpulan penelitian adalah ekstrak etanol daun pepaya varietas calina memiliki potensi sebagai agen imunomodulator alami.
Phytochemical analysis and antifungal activity of Costus lucanusianus J. Braun & K. Schum aerial and rhizome crude extracts

The phytochemical screening, and in vitro antifungal activity of the inflorescence, leaf, stem and rhizome crude extracts of Costus lucanusianus J. Braun & K. Schum at concentrations 12.5-100 µg/mL were determined against 4 fungal strains; Penicillium notatum, Candida albicans, Aspergillus niger and Rhizopus stolonifer by Agar well diffusion method. Secondary metabolites accountable for the activity observed are saponin, tannin, flavonoid, phlobatannins, reducing sugar, anthraquinones, phenol, alkaloid, resin, glycoside and terpenoids. Reducing sugar was present in all the extracts. The rhizome solvent extracts displayed the highest antifungal activity amongst the organs extracts. The inflorescence, stem and rhizome aqueous extracts displayed no activity at all concentrations. In this present study, the antifungal activity of Costus lucanusianus J. Braun & K.Schum aerial and rhizome extracts is reported. The activity shown by the plant organs justifies the use of the plant in the treatment of urinary tract infection and venereal diseases in ethnomedicine, and its usefulness in the preservation of food crops.
The effectiveness of online mindfulness-based cancer recovery program on psychological Variables of colorectal and stomach cancer patients: A randomized control trial

Background: This study aimed to investigate the effectiveness of an online version of a mindfulness-based recovery program (E-MBCR) on stress, cancerrelated fatigue, and sleep disturbances in colorectal and stomach cancer patients. Method: In a randomized controlled trial, 50 cancer patients (34% colon, 28% rectum, 38% stomach) were recruited by convenience sampling from oncology departments of two hospitals and were randomly allocated to intervention (n=25) and control groups (n=25). The experimental group participated in a 9-week online mindfulness-based cancer recovery program. Outcome measures were assessed at three phases (pre-test, post-test, and twomonths follow-up) by DASS-21, fatigue symptom subscale of QLQ-C30, and the Insomnia severity index. Results: Mixed linear models revealed significant improvements in cancer-related symptoms, including stress (F=43.01, P=0.00, η2=0.50), fatigue (F=33.40, P=0.00, η2=0.43), and sleep disturbances (F=39.14, P=0.00, η2=0.47), in colorectal and stomach cancer patients. Conclusion: EMBCR can be considered as having potential utility to ameliorate cancer patients’ psychological disturbances.
Anopheles albimanus (Diptera: Culicidae) Ensemble Distribution Modeling: Applications for Malaria Elimination

Simple Summary Costa Rica is near malaria elimination. However, sporadic outbreaks still occur, and while control strategies have been focused on delivering efficient treatments for infected patients, an open question is whether control measures targeting the dominant vector, Anopheles albimanus, are appropriately designed given their ecology and distribution. Here, we illustrate the use of an ensemble species distribution model (SDM) as a tool to assess the potential exposure to An. albimanus in palm and pineapple plantations, and to also assess the potential involvement of this mosquito vector in transmission foci where entomological surveillance is not feasible. We found that both oil palm and pineapple plantations are very likely to harbor An. albimanus. By contrast, environments at the Crucitas open-pit gold mine, the epicenter of malaria transmission in 2018 and 2019, have low suitability for this mosquito species. Our results suggest that medium to high resolution SDMs can be used to plan vector control activities. Finally, we discuss the high suitability of oil palm and pineapple plantations for An. albimanus in reference to recently developed social science theory about the Plantationocene. Abstract In the absence of entomological information, tools for predicting Anopheles spp. presence can help evaluate the entomological risk of malaria transmission. Here, we illustrate how species distribution models (SDM) could quantify potential dominant vector species presence in malaria elimination settings. We fitted a 250 m resolution ensemble SDM for Anopheles albimanus Wiedemann. The ensemble SDM included predictions based on seven different algorithms, 110 occurrence records and 70 model projections. SDM covariates included nine environmental variables that were selected based on their importance from an original set of 28 layers that included remotely and spatially interpolated locally measured variables for the land surface of Costa Rica. Goodness of fit for the ensemble SDM was very high, with a minimum AUC of 0.79. We used the resulting ensemble SDM to evaluate differences in habitat suitability (HS) between commercial plantations and surrounding landscapes, finding a higher HS in pineapple and oil palm plantations, suggestive of An. albimanus presence, than in surrounding landscapes. The ensemble SDM suggested a low HS for An. albimanus at the presumed epicenter of malaria transmission during 2018–2019 in Costa Rica, yet this vector was likely present at the two main towns also affected by the epidemic. Our results illustrate how ensemble SDMs in malaria elimination settings can provide information that could help to improve vector surveillance and control.
Effect of inoculation with arbuscular mycorrhizal fungi on growth of Catalpa bungei

Background: Catalpa bungei is a well-known, valuable, ornamental, high-quality timber tree traditionally cultivated in China because of its excellent quality, decay resistance, wide applicability, and attractive form. The aim of this study was to evaluate the effects of inoculation with arbuscular mycorrhizal fungus (AMF) on the transplant survival rate and growth of C. bungei seedlings under greenhouse conditions. Methods: Two treatments were applied in a completely randomized experimental design: inoculation with Rhizophagus intraradices, and, as a control, soil without inoculum. Results: Four months after inoculation, AMF had colonized 76.05% of plant roots and significantly improved plant growth. With the establishment of the symbiotic relationship, AMF inoculation significantly improved the seedling transplant survival rate by 20%, promoted major growth traits (plant height, basal diameter, leaf area, and specific leaf area), accelerated biomass accumulation (roots, stems, and leaves), and changed the biomass allocation patterns. In addition, compared with non-inoculated treatments, inoculation with AMF increased photosynthetic parameters and chlorophyll contents, elevated major root morphological parameters, changed the proportion of particle sizes of soil micro-aggregates, and promoted the accumulation of nutrients in roots and leaves. Conclusions: The effects on transplant survival, growth and development were more pronounced in C. bungei seedlings inoculated with R. intraradices. Mycorrhizal seedlings of C. bungei can therefore be widely applied in plant transplantation and production practices.
Effects of Integrated Moral Reasoning Development Intervention for Management of Violence in Schizophrenia: A Randomized Controlled Trial

Moral cognition is an important and multidimensional, but often overlooked, determinant of violence. Very few interventions have systematically examined the role of moral reasoning, anger management and problem-solving together in violence. A randomized controlled trial was conducted to comprehensively evaluate the sustained effects of an integrated Moral Reasoning Development Intervention (MRDI) in the management of repetitive violence in schizophrenia. This study placed special emphasis on essential components related to moral reasoning and violence in patients with schizophrenia. Evaluations, including measures of violence, moral reasoning, ethical valuation and judgement, decision-making, conflict management style, and personality traits, were performed at baseline, end of intervention, and 1-month follow-up after intervention. We found that MRDI was superior to treatment-as-usual, in improving moral reasoning and related variables and violence outcomes (p < 0.05). In comparison with the treatment-as-usual group (n = 22), patients in the MRDI group (n = 21) showed improved levels of moral reasoning, with decreased levels of violent behaviors. The MRDI participants also experienced significantly greater improvements or changes (p < 0.05) in their ethical valuation and judgement, decision-making style and preferences, and conflict management style. Our findings provide important implications for risk assessment and violence management and prevention.
Automated End-Effector Alignment in Robotic Micromanipulation

Proper alignment of the end-effector is a critical procedure that determines the success of micromanipulation, such as robotic cell manipulation. Presently, end-effector alignment is performed manually and suffers from large misalignment error and inconsistency. Manual alignment often undesirably moves the end-effector (e.g., a glass micropipette) out of the limited field of view under microscopy and risks breaking the fragile end-effector. This article presents automated end-effector alignment in robotic micromanipulation. A rotational degree of freedom was added to a standard micromanipulator with translational degrees of freedom. The kinematic model of end-effector’s rotation was established, and the unknown model parameters were calibrated. To accommodate model uncertainty and parameter variations, a sliding mode controller was designed to achieve end-effector alignment. Experimental results demonstrate that the robotic alignment technique achieved an accuracy of 0.5<inline-formula><tex-math notation="LaTeX">$\pm 0.3^{\circ }$</tex-math></inline-formula> and a time cost of 17.9<inline-formula><tex-math notation="LaTeX">$\pm$</tex-math></inline-formula>7.3 s, both significantly less than manual alignment. The developed controller based on kinematic modeling and sliding mode control achieved a higher success rate and significantly less time cost for end-effector alignment than the PID controller. Standard micropipettes were used as the end-effectors for sperm immobilization and oocyte penetration, important procedures in cell surgeries. The success rate of sperm immobilization was 98% by robotic micropipette alignment, higher than the success rate of 90% by manual alignment. Oocyte deformation before penetration was 28.1<inline-formula><tex-math notation="LaTeX">$\pm$</tex-math></inline-formula>7.5 <inline-formula><tex-math notation="LaTeX">$\mu$</tex-math></inline-formula>m by robotic end-effector alignment, significantly less than the deformation of 54.5<inline-formula><tex-math notation="LaTeX">$\pm$</tex-math></inline-formula>13.2 <inline-formula><tex-math notation="LaTeX">$\mu$</tex-math></inline-formula>m by manual alignment.
Gender Disaggregated Perspectives of Tourism and Hospitality Training in Uganda

ABSTRACT Tourism and hospitality industry require competent and skilled human resources to meet the industry’s needs and keep it competitive. This study, undertaken at Makerere University, Uganda, examined gender segregated core skills desired by employers in the tourism and hospitality industry and students’ perception of internship training. Using documentary review and focus group discussions, data were collected and subjected to content and thematic analysis, an independent t-test and exploratory factor analysis. Results reveal that different skill sets categorized under personal and adaptability attributes are desired by employers in Uganda’s tourism and hospitality industry. Gender did not influence students’ choice of organizations for internship training. However, there were gender-based variations that influenced the training outcomes. The study recommends strengthening of training to enhance skills in communication, team work, time management, and presentability desired by employers in the industry. A pathway is proposed to enable tourism and hospitality training to become gender transformative.
Control and protection system for motor based on CAN bus

A control and protection system for motor is proposed ,which is based on CAN ( Con - troller Area Network ) bus.The system functions ,hardware design and software flows are discussed.The system consists of the monitoring and control center ,the communication module ,the data sampling and processing module.It has control and protection ,measuring and communication func - tions ,which realizes the automatic ,intelligent and net - like management of motor.