Miracle-dz/UniFAR-FTUs huggingface dataset:
Determination of 3-MeO-PCP in human blood and urine in a fatal intoxication case, with a specific focus on metabolites identification

Abstract 3-Methoxyphencyclidine (3-MeO-PCP) is a new psychoactive substance that belongs to the phencyclidines family, first identified in Europe in 2012. This drug presents a stronger binding to N-methyl-D-aspartate (NMDA) receptors when compared to phencyclidine, which results in more potent effects, even at low concentrations. Very few articles have been published regarding 3-MeO-PCP in forensic toxicology. In this paper, the authors present a fatal 3-MeO-PCP intoxication case. In addition to the detection of the parent drug, metabolites were investigated in urine and, for the first time in the scientific literature, in blood. 3-MeO-PCP and its metabolites were quantitated by liquid chromatography-tandem mass spectrometry system (LC-MS/MS). Identification was confirmed by liquid chromatography-high resolution mass spectrometry (LC-HRMS). 3-MeO-PCP tested positive in femoral blood (3 525 ng/mL) and urine (7 384 ng/mL). The femoral blood concentration was higher than the fatal concentrations range already reported in the literature (from 50 to 3 200 ng/mL). 3-MeO-PCP metabolites, including O-demethyl-3-MeO-PCP, piperidine-OH-3-MeO-PCP, O-demethyl-piperidine-di-OH-3-MeO-PCP and piperidine-di-OH-3-MeO-PCP, were detected in blood. In addition, two new metabolites, O-demethyl-piperidine-OH-3-MeO-PCP and O-demethyl-cyclohexyl-OH, were identified in both blood and urine. Unfortunately, due to the lack of reference material on the market, it was not possible to measure the concentration of these metabolites. However, the ratios between the metabolites and the parent drug were useful to estimate their analytical response and prevalence. At this time, considering the low ratios (<1) between metabolites and parent drug, metabolites testing does not seem useful to increase the detection window of the drug.
Renal transplant recipients suffer significantly more complications but not mortality after breast cancer surgery and benefit from treatment at transplant centers

Background: Breast carcinoma has the highest incidence of any cancer in adult females. The impact of a previous kidney transplant (KT) on breast cancer surgery outcomes has not been examined. We aim to evaluate the influence of a KT on the short-term outcomes of mastectomy or lumpectomy to inform future treatment decisions in this population. Methods: A retrospective cohort analysis was conducted using Nationwide Inpatient Sample (NIS) data between 2005 and 2014. Population included adult females with KT surgically treated for breast malignancy. Weighted multivariate regression models were employed to compare outcomes at transplant and nontransplant centers. Results: Three hundred and ninety-eight women met the inclusion criteria. KT recipients (KTR) had higher Elixhauser Comorbidity Index (ECI). We noted longer length of stay (P<0.001), higher expenditure (P=0.001), and complications (P<0.001). Specifically, rates of hematomas (P=0.041), acute renal failure (P<0.001), blood transfusion (P<0.001), fresh frozen plasma transfusion (P<0.001), cardiovascular (P<001), and other complications (P=0.012) were increased. There was no mortality in transplant recipients. Weighted multivariate analyses highlight that rates of complication (P=0.040), and length of stay (P<0.001) are lower at transplant centers (TCs). Conclusions: History of KT has a significant impact on the outcomes of mastectomy or lumpectomy. These patients suffer more post-operative adverse events. However, KTR experience superior outcomes at TCs.
Gender Differences and Learner Satisfaction: An evaluation of E-Learning Systems at Umm A-Qura University

This research aims to define the students' satisfaction level at Umm Al-Qura ‎University with the e-learning systems (Blackboard & D2L), in addition, it ‎investigates whether there are differences in the evaluation of Umm Al-Qura ‎University students for e-learning systems (Blackboard & D2L) due to the gender ‎variable (Male/ Female). ‎ To achieve these goals, a descriptive analysis methodology used in this research, ‎the sample consisted of (513) students, (174) male, and (339) female at Umm Al-Qura ‎University in the the academic year 2019/2020. The sample were asked to complete a ‎‎5-point likert scale questionnaire to collect the required data. Validity and reliability of ‎the questionnaire were guaranteed. ‎ The results revealed that students are highly satisfied with the both of e-learning ‎systems (Blackboard & D2L). There is no statistically significant difference between ‎the average scores of males and females in the evaluation of the e-learning system ‎‎(Blackboard). There is a statistically significant difference between the mean scores of ‎males and females in the D2L system evaluation in favor of females
Effects of aphid disoperation on photosynthetic performance and agronomic traits of different sorghum varieties

The current study used photosynthetic indexes to investigate the mechanism of aphid resistance in two sorghum varieties with different aphid tolerance. (Pn, Tr, Gs, Ci), chlorophyll fluorescence parameters (Fo, Fm, Fv/Fm, Y (II), qP, NPQ) as well as some agronomic traits (chlorophyll content, plant height, fresh weight, dry weight, root length, root number) that treated at different aphid densities (0, 10, 20 and 40 aphids/plant) and at different infestation times (4d, 8d, 12d and 16d). The results showed that, as aphid density and infestation time increased, the agronomic traits, the most photosynthetic parameters and the most chlorophyll fluorescence parameters showed a larger decrease in sensitive sorghum variety, whereas a minor decrease was observed correspondingly in the resistant variety. Comprehensive analysis indicated that five indicators, including Pn, Tr, Gs, Y(II), qP and chlorophyll content, were easily disturbed under large density of aphid and long infestation time. Among which three indicators, including chlorophyll content, Pn and Y (II), played a crucial role in promoting crop yield and thus could be considered as the key indicators in studying the aphid resistance in sorghum.
An efficient CHA‐WMA control strategy for a non‐isolated quasi‐Z‐source novel multilevel inverter‐based grid connected PV system

This manuscript proposes a hybrid approach for non‐isolated quasi Z‐source (QZS)‐novel cascaded multilevel inverter (NIQZS‐NMLI)‐based grid‐connected photovoltaic (PV) system. The proposed hybrid approach is the combined execution of both the color harmony algorithm (CHA) and woodpecker‐mating algorithm (WMA), and hence it is called CHA‐WMA method. Initially, the NIQZS‐NMLI design is developed to gain the optimal control signal using the proposed controller. The NIQZS‐NMLI is developed with the reduced count of switches, diodes, and sources. The major objective of the proposed method is “to satisfy the load power requirement and to maintain the power regulation or maximum energy conversion of the wind and solar subsystems. ” The proposed method strictly prohibits the variations present in the output voltage of the NIQZS‐NMLI. Here, the CHA is employed to evaluate the optimal gain parameters in light of the source currents variety from the normal value, also it is useful for generating the optimum control signals dataset in the offline way. In the online way, the WMA predicts the most optimal control signals of the NIQZS‐NMLI in light of the satisfied dataset. The resultant control signals have been utilized for controlling the insulated gate bi‐polar switches (IGBT) of NIQZS‐NMLI. The proposed method is implemented in MATLAB/Simulink site and the performance is analyzed with existing methods. Moreover, the PV performance is analyzed under three test cases. The PV efficiency of the proposed method for all cases is 89.3975%, 90.2653%, and 97.8095%. Overall, the comparison outcomes demonstrate that the proposed method is more efficient than the other existing methods.
Gender and socioeconomic inequalities in health and wellbeing across age in France and Switzerland

There is increasing evidence that wellbeing is unequally distributed across sociodemographicgroups in contemporary societies. However, less is known about thedivergence across social groups of trajectories of wellbeing across age groups.This issue is of great relevance in contexts characterised by changing populationstructures and growing imbalances across and within generations, and in whichensuring that everyone has the opportunity to have a happy and healthy life courseis a primary welfare goal. In this study, we investigate wellbeing trends in Franceand Switzerland across age, gender, and socioeconomic status groups. We use twohousehold surveys (the Sant´e et Itin´eraires Professionnels and the Swiss HouseholdPanel) to compare the unfolding inequalities in health and wellbeing across agegroups in two rich countries. We view wellbeing as multidimensional, followingthe literature highlighting the importance of considering different dimensions andmeasures of wellbeing. Thus, we investigate a number of outcomes, includingdifferent measures of physical and mental health, as well as of relational wellbeing,using a linear regression model and a linear probability model. Our findings showinteresting country and dimension-specific heterogeneities in the development ofhealth and wellbeing over age. While our results indicate that there are gender andeducational inequalities in both Switzerland and France, and that gender inequalitiesin mental health accumulate with age in both countries, we also find that educationalinequalities in health and wellbeing remain rather stable across age groups.
Design strategies of an unobscured three mirror telescope with freeform surfaces for infrared nanosatellite imagery

The new degrees of freedom offered by the new family of freeform surfaces helps compensating for off axis aberrations in optical designs. We define a freeform surface as a non-rotationally symmetric surface which cannot be described as an off-axis part of a conicoid. The use of freeform surfaces allows an increase in performance such as on the field of view, the F-number and compactness of unobscured all reflective telescopes. Reflective designs have the advantage of being light, achromatic, and potentially low-cost due to cheaper materials involved. It could result in industrial production of compact panchromatic systems for various applications ranging from automotive sensors to imaging nanosatellites. In this paper we address the challenges posed by the use of these surfaces in optical design optimization, specifically the minimization of the surface counting, in order to simplify the manufacturing, assembly and integration phases. We focus on three mirror designs and work on the compactness with various flavors in the 3D space. We will discuss our results on a fast, unobscured, non reimaging and well corrected three mirror anastigmat (TMA) design for a nanosatellite thermal imaging payload using uncooled bolometers. Optimization method of a TMA under volume and straylight constraints is described. A tolerance analysis is performed and minimal alignment is required even for large tolerances.
A 14bit 500MS/s 85.62dBc SFDR 66.29dB SNDR SHA-less pipelined ADC with a stable and high-linearity input buffer and aperture-error calibration in 40nm CMOS

This paper presents a 14bit 500MS/s SHA-less pipelined analog-to-digital converter (ADC) implemented in 40nm CMOS. A high-linearity pseudo-diﬀerential push-pull input buﬀer with an anti-oscillation technique and a nonlinear parasitism eliminate technique is proposed to stably drive the pipelined stages while keeping low distortion. Moreover, a digital controlled aperture-error calibration is also employed with oﬀset of comparators compensated in advance. Measurement results show that the ADC achieves a signal-to-noise-and-distortion-ratio (SNDR) of 66.29dB and a spurious-free-dynamic-range (SFDR) of 85.62dBc at 80.1MHz input.
Association Between Smoking and Molecular Subtypes of Colorectal Cancer

Abstract Background Smoking is associated with colorectal cancer (CRC) risk. Previous studies suggested this association may be restricted to certain molecular subtypes of CRC, but large-scale comprehensive analysis is lacking. Methods A total of 9789 CRC cases and 11 231 controls of European ancestry from 11 observational studies were included. We harmonized smoking variables across studies and derived sex study–specific quartiles of pack-years of smoking for analysis. Four somatic colorectal tumor markers were assessed individually and in combination, including BRAF mutation, KRAS mutation, CpG island methylator phenotype (CIMP), and microsatellite instability (MSI) status. A multinomial logistic regression analysis was used to assess the association between smoking and risk of CRC subtypes by molecular characteristics, adjusting for age, sex, and study. All statistical tests were 2-sided and adjusted for Bonferroni correction. Results Heavier smoking was associated with higher risk of CRC overall and stratified by individual markers (Ptrend < .001). The associations differed statistically significantly between all molecular subtypes, which was the most statistically significant for CIMP and BRAF. Compared with never-smokers, smokers in the fourth quartile of pack-years had a 90% higher risk of CIMP-positive CRC (odds ratio = 1.90, 95% confidence interval = 1.60 to 2.26) but only 35% higher risk for CIMP-negative CRC (odds ratio = 1.35, 95% confidence interval = 1.22 to 1.49; Pdifference = 2.1 x 10-6). The association was also stronger in tumors that were CIMP positive, MSI high, or KRAS wild type when combined (Pdifference < .001). Conclusion Smoking was associated with differential risk of CRC subtypes defined by molecular characteristics. Heavier smokers had particularly higher risk of CRC subtypes that were CIMP positive and MSI high in combination, suggesting that smoking may be involved in the development of colorectal tumors via the serrated pathway.
The Electoral Consequences of Scandals: A Meta-Analysis

As the number of scandals involving politicians in office rises worldwide, the number of studies dedicated to analysing these scandals and their consequences rises as well. In this article, we try to summarise this emerging literature focusing on quantitative studies that use scandal as an independent variable to model its influence on politicians’ electoral results. The analysis finds that scandal-ridden politicians tend to get fewer votes at the ballot box, are more likely to lose elections, and are less likely to win re-election. It also finds that the link between scandal and turnout is unclear; some models indicate that scandals depress turnout, while others report an increase in turnout.
Systematic Review of the Integrative Medicine Recommendations for Patients with Pancreatic Cancer

Introduction: Integrative medicine (IM) is a relatively new field where non-traditional therapies with peer-reviewed evidence are incorporated or integrated with more traditional approaches. Methods: A systematic review of the literature from the last 10 years was done by searching clinical trials and randomized-controlled trials on Pubmed that discuss nutrition, supplementation, and lifestyle changes associated with “Pancreatic Cancer. ” Results: Only 50 articles ultimately met the inclusion criteria for this review. A total of 15 articles discussed the role of obesity and 10 discussed the influence of stress in increasing the risk of pancreatic cancer. Six discussed the potential beneficial role of Vitamins, 5 of cannabinoids, 4 an anti-inflammatory diet, 3 of nut consumption, 2 of green tea consumption, 2 of curcumin supplementation, 1 role of melatonin, and 1 of probiotics. One article each was found on the theoretical benefits of adhering to either a Mediterranean or ketogenic diet. Discussion: As more surgeons become interested in IM, it is hoped that more diseases where the curative treatment is mainly surgical can benefit from the all-encompassing principles of IM in an effort to improve quality of life and survival in patients with pancreatic cancer.
“Y Sin Embargo Te Quiero” (And Yet, I Love You): An Ethnographic Study of Economic Policy and Colonial Hegemonies Encoded in the Recommodification of Used Garments

Abstract The colonial project of redistributing secondhand clothing globally can be seen fully realized in the current manifestation of the trans-global distribution of secondhand garments. In Havana however, the Clandestina brand brilliantly subverts this process. Their products are made up of old t-shirts and garments that originated in North America and Europe and were purchased cheaply through government-run Cuban stores. These are then re-cut and re-sewn into stylish shapes and silk-screened with graphics that subvert the original messages of the t-shirts. This essay examines the history of secondhand clothing as well as the current impacts of the glut of secondhand goods. It also highlights the fledgling entrepreneurial movement happening in Cuba, wherein an independent business can be operated within a trade-sector, in this case: tailoring or dressmaking. Methodology examines the sociohistorical development of the modern used clothes distribution economy, and also includes an interview with the Clandestina designers. Examining in particular how they took a commodity that was completely devalued (dumped on another marketplace), and through their ingenuity and “revolutionary vision” created a product far more valuable than the original materials. By doing so, Clandestina has created a product that is uniquely Havanero, but ready to take on the world.
The Offense-Specific Nature of Gender and Familial Responsibility in United States Federal Sentencing, 2010–2016

Prior sentencing research has identified leniency afforded to females (compared with males) and those with familial responsibility (compared with those without). Studies have also found that the effect of defendant gender, familial responsibility, and their intersections depend on the type of offense examined. What remains unclear is the situations in which these factors matter more or less. The purpose of this study is to disaggregate extralegal effects by understanding how gender, familial responsibility, and their intersections influence federal sentencing outcomes across various offense types. Findings from this study suggest that gender, familial responsibility, and their combinations exert different influences depending on the (a) dependent variable and (b) offense type examined.
Phase II, Non-Randomized Study of Chemo-Chemoradio-Chemo Sequential Therapy Compared With Concomitant Chemoradiotherapy In Magnetic Resonance Imaging Defined, Locally Mid/Low Advanced Rectal Cancer

ObjectiveThe conventional preoperative CRT provides local tumor control in most LARC patients. However, long-term survival has not obviously improved. Thus, the optimal neoadjuvant treatment is still controversial. Sandwich therapy may be associated with better efficacy.Methods The present study is a single-center, open-label, phase II, non-randomized trial (Clinical trials number: NCT02022852). Pathological diagnosis of eligible patients were as rectal adenocarcinoma and they were clinically confirmed by MRI as cT3-4NxM0, with distal border located＜10cm from anal verge. Hundred and seventy-two patients between July 2013 and July 2015 were enrolled for the trial. The enrolled patients were non-randomly assigned into two treatment types (arm A and arm B). Patients in arm A received capecitabine-based concurrent CRT 25 fractions. In contrast, arm B patients received sequential therapy as induction CapeOx for two cycles, followed by 25 fractions CRT, finally adding one consolidation CapeOx cycle. After preoperative treatment, TME with different adjuvant therapy types were performed in patients.ResultsWith treatment processing, 48 patients were excluded from the trial due to personal reasons and intolerance to treatment toxicities. Finally, there were 61 patients in arm A and 63 patients in arm B (70.9% vs. 73.2%). The 5-years DFS and OS didn’t show significant difference in two arms. However, the postoperative complications of arms A and B were 4.9% and 17.5% (P=0.027). ConclusionsSandwich therapy may lead more postoperative complications than conventional CRT, so that the safety should further research. Compared with conventional CRT, sandwich therapy doesn’t show significant advantage in survival.
Design and evaluation of a novel upper limb rehabilitation robot with space training based on an end effector

Abstract. The target of this paper is to design a lightweight upper limb rehabilitation robot with space training based on end-effector configuration and to evaluate the performance of the proposed mechanism. In order to implement this purpose, an equivalent mechanism to the human being upper limb is proposed before the design. Then, a 4 degrees of freedom (DOF) end-effector-based upper limb rehabilitation robot configuration is designed to help stroke patients perform space rehabilitation training of the shoulder flexion/extension and adduction/abduction and elbow flexion/extension. Thereafter, its kinematical model is established together with the proposed equivalent upper limb mechanism. The Monte Carlo method is employed to establish their workspace. The results show that the overlap of the workspace between the proposed mechanism and the equivalent mechanism is 96.61 %. In addition, this paper also constructs a human–machine closed-chain mechanism to analyze the flexibility of the mechanism. According to the relative manipulability and manipulability ellipsoid, the highly flexible area of the mechanism accounts for 67.6 %, and the mechanism is far away from the singularity on the drinking trajectory. In the end, the single-joint training experiments and a drinking water training trajectory planning experiment are developed and the prototype is manufactured to verify it.
Co-constructions, co-performances and co-reflections in early years qualitative research

This study investigates our role as early years researchers in qualitative data analysis. We draw on our doctoral studies to address how the co-construction, co-performance and co-reflection of narratives elicit deeper and new understandings of early years workers in England, and how our life stories are co-produced through narrative inquiry. Employing a constructionist approach and building on Buitelaar theorisation of I-positions and the multi-vocal ‘self’, we explore how narratives are co-constructed and co-performed between the researched and researcher in relation to the ‘self’ and master narratives of culture, time and place. Data were collected using focus groups and semi-structured interviews involving 50 early years workers and 17 nurseries situated in the South East of England. By ‘co-reflecting’ on how the data was analysed, we discussed the ways in which we and our participants are simultaneously positioned within social categories of intersectionality, such as gender, social class, mother and worker. Our reflections offer a broader understanding of how qualitative research can enrich existing knowledge of how early years workers and their practice are constructed in England.