Miracle-dz/UniFAR-FTUs huggingface dataset:
Multimodal magnetic resonance imaging reveals distinct sensitivity of hippocampal subfields in asymptomatic stage of Alzheimer’s disease

While hippocampal atrophy and its regional susceptibility to Alzheimer’s disease (AD) are well reported at late stages of AD, studies of the asymptomatic stage of AD are limited but could elucidate early stage pathophysiology as well as provide predictive biomarkers. In this study, we performed multi-modal magnetic resonance imaging (MRI) to estimate morphometry, functional connectivity, and tissue microstructure of hippocampal subfields in cognitively normal adults including those with asymptomatic AD. High-resolution resting-state functional, diffusion and structural MRI, cerebral spinal fluid (CSF), and neuropsychological evaluations were performed in healthy young adults (HY: n = 40) and healthy older adults with negative (HO−: n = 47) and positive (HO+ : n = 25) CSF biomarkers of AD. Morphometry, functional connectivity, and tissue microstructure were estimated from the structural, functional, and diffusion MRI images, respectively. Our results indicated that normal aging affected morphometry, connectivity, and microstructure in all hippocampal subfields, while the subiculum and CA1-3 demonstrated the greatest sensitivity to asymptomatic AD pathology. Tau, rather than amyloid-β, was closely associated with imaging-derived synaptic and microstructural measures. Microstructural metrics were significantly associated with neuropsychological assessments. These findings suggest that the subiculum and CA1-3 are the most vulnerable in asymptomatic AD and tau level is driving these early changes.
PARAMETRIC ESTIMATION OF INVERSE RESPONSE PROCESS COMPRISING OF FIRST ORDER SYSTEM AND A PURE CAPACITIVE SYSTEM

The classical example of an integrating process with inverse response is liquid level control in a simple drum boiler system. It is noticed that initially the response is in opposite direction to where it eventually ends up. The swelling behaviour may be modelled as the net result of opposite effects of a pure integrator and a first order system without any time delay. This paper helps to estimate the transfer function parameters of the process from its unit step response. The procedure is based on graphical evaluation of the given process with suitable mathematical equations.
Matricellular protein tenascin C: Implications in glioma progression, gliomagenesis, and treatment

Matricellular proteins are nonstructural extracellular matrix components that are expressed at low levels in normal adult tissues and are upregulated during development or under pathological conditions. Tenascin C (TNC), a matricellular protein, is a hexameric and multimodular glycoprotein with different molecular forms that is produced by alternative splicing and post-translational modifications. Malignant gliomas are the most common and aggressive primary brain cancer of the central nervous system. Despite continued advances in multimodal therapy, the prognosis of gliomas remains poor. The main reasons for such poor outcomes are the heterogeneity and adaptability caused by the tumor microenvironment and glioma stem cells. It has been shown that TNC is present in the glioma microenvironment and glioma stem cell niches, and that it promotes malignant properties, such as neovascularization, proliferation, invasiveness, and immunomodulation. TNC is abundantly expressed in neural stem cell niches and plays a role in neurogenesis. Notably, there is increasing evidence showing that neural stem cells in the subventricular zone may be the cells of origin of gliomas. Here, we review the evidence regarding the role of TNC in glioma progression, propose a potential association between TNC and gliomagenesis, and summarize its clinical applications. Collectively, TNC is an appealing focus for advancing our understanding of gliomas.
A systematic review and Meta-analysis of urinary extracellular vesicles proteome in diabetic nephropathy

Diabetic nephropathy (DN) is a major microvascular complication of both type 1 and type 2 diabetes mellitus and is the most frequent cause of end-stage renal disease with an increasing prevalence. Presently there is no non-invasive method for differential diagnosis, and an efficient target therapy is lacking. Extracellular vesicles (EV), including exosomes, microvesicles, and apoptotic bodies, are present in various body fluids such as blood, cerebrospinal fluid, and urine. Proteins in EV are speculated to be involved in various processes of disease and reflect the original cells’ physiological states and pathological conditions. This systematic review is based on urinary extracellular vesicles studies, which enrolled patients with DN and investigated the proteins in urinary EV. We systematically reviewed articles from the PubMed, Embase, Web of Science databases, and China National Knowledge Infrastructure (CNKI) database until January 4, 2022. The article quality was appraised according to the Newcastle-Ottawa Quality Assessment Scale (NOS). The methodology of samples, isolation and purification techniques of urinary EV, and characterization methods are summarized. Molecular functions, biological processes, and pathways were enriched in all retrievable urinary EV proteins. Protein-protein interaction analysis (PPI) revealed pathways of potential biomarkers. A total of 539 articles were retrieved, and 13 eligible records were enrolled in this systematic review and meta-analysis. And two studies performed mass spectrometry to obtain the proteome profile. Two of them enrolled only T1DM patients, two studies enrolled both patients with T1DM and T2DM, and other the nine studies focused on T2DM patients. In total 988 participants were enrolled, and DN was diagnosed according to UACR, UAER, or decreased GFR. Totally 579 urinary EV proteins were detected and 28 of them showed a potential value to be biomarkers. The results of bioinformatics analysis revealed that urinary EV may participate in DN through various pathways such as angiogenesis, biogenesis of EV, renin-angiotensin system, fluid shear stress and atherosclerosis, collagen degradation, and immune system. Besides that, it is necessary to report results compliant with the guideline of ISEV, in orderto assure repeatability and help for further studies. This systematic review concordance with previous studies and the results of meta-analysis may help to value the methodology details when urinary EV proteins were reported, and also help to deepen the understanding of urinary EV proteins in DN.
Impaired feedforward control of movements in pianists with focal dystonia

Learning accurate and fast movements typically accompanies the modulation of feedforward control. Nevertheless, it remains unclear how motor skill learning modulates feedforward control, such as through maladaptation of the sensorimotor system by extensive training (e.g., task-specific dystonia). Here, we examined the modulation of feedforward control through motor skill learning while focusing on the motion of piano playing at either a natural tempo or the fastest tempo. The current study compared the kinematics and keypress data among individuals in three groups: healthy and well-trained pianists (i.e., subjects with skill learning), non-musicians (i.e., subjects without skill learning), and patients with focal-hand dystonia (FHD) (i.e., subjects with maladaptation by skill learning). Compared to healthy pianists, patients with FHD showed impairment in some feedforward motion components that are relevant to classifying the two playing tempi. However, while focusing on motion components that are irrelevant to the tempo classification, patients with FHD showed movements comparable to those of healthy pianists. Furthermore, patients with FHD demonstrated significantly slower movement times than healthy pianists. Our results suggest that maladaptation by skill learning affects parts of feedforward control rather than its entirety. Nevertheless, the affected feedforward components are relevant to performing movements as fast as possible, which may underlie the speed dependence of dystonic symptoms.
ADD1 Single Nucleotide Polymorphisms Are Associated With Essential Hypertension Among Han and Mongolian Population in Inner Mongolia Area

Aldosterone synthase (CYP11B2) and α-adducing (ADD1) are candidate genes that play key roles during essential hypertension (EH) incidence. However, the association between their genetic mutations and the risk of EH is unclear. The present study investigated specific single nucleotide polymorphisms (SNPs) from CYP11B2 and ADD1, and their potential role as risk factors for EH based on 423 Mongolian and 410 Han people in Inner Mongolia province. In the allelic model, people with ADD1 rs2239728-A presented a 0.74-fold risk than rs2239728-C, whereas the ADD1 rs4961-T was associated with a 1.37-fold higher risk than allele G in the Han population. The genetic model reported that the rs2239728-A carrier (AA + AC) was 0.59-fold lower than the CC carrier, whereas the rs4961-G carrier (GG + GT) was 0.59-fold lower than the TT carrier in the dominant model. After gender adjustment, people with rs2239728-A was a 0.63-fold risk than –C in EH, but the rs4961-T carrier was associated with a 1.63-times higher risk than –G in females. Haplotype analysis showed that GCCT was associated with essential hypertension in the Han population, and it was a risk factor for EH. Our identification reported novel SNPs of ADD1 with protective significance for EH among females in the Chinese Han population, together with its haplotype GCCT as a risk factor for EH.
Endothelitis profile in acute heart failure and cardiogenic shock patients: Endocan as a potential novel biomarker and putative therapeutic target

Aims: Inflammation-driven endothelitis seems to be a hallmark of acute heart failure (AHF) and cardiogenic shock (CS). Endocan, a soluble proteoglycan secreted by the activated endothelium, contributes to inflammation and endothelial dysfunction, but has been scarcely explored in human AHF. We aimed to evaluate serum (S-Endocan) and urinary endocan (U-Endocan) profiles in AHF and CS patients and to correlate them with biomarkers/parameters of inflammation, endothelial activation, cardiovascular dysfunction and prognosis. Methods: Blood and spot urine were collected from patients with AHF (n = 23) or CS (n = 25) at days 1–2 (admission), 3-4 and 5-8 and from controls (blood donors, n = 22) at a single time point. S-Endocan, U-Endocan, serum IL-1β, IL-6, tumour necrosis factor-α (S-TNF-α), intercellular adhesion molecule-1 (S-ICAM-1), vascular cell adhesion molecule-1 (S-VCAM-1) and E-selectin were determined by ELISA or multiplex immunoassays. Serum C-reactive protein (S-CRP), plasma B-type natriuretic peptide (P-BNP) and high-sensitivity troponin I (P-hs-trop I), lactate, urea, creatinine and urinary proteins, as well as prognostic scores (APACHE II, SAPS II) and echocardiographic left ventricular ejection fraction (LVEF) were also evaluated. Results: Admission S-Endocan was higher in both patient groups, with CS presenting greater values than AHF (AHF and CS vs. Controls, p < 0.001; CS vs. AHF, p < 0.01). Admission U-Endocan was only higher in CS patients (p < 0.01 vs. Controls). At admission, S-VCAM-1, S-IL-6 and S-TNF-α were also higher in both patient groups but there were no differences in S-E-selectin and S-IL-1β among the groups, nor in P-BNP, S-CRP or renal function between AHF and CS. Neither endocan nor other endothelial and inflammatory markers were reduced during hospitalization (p > 0.05). S-Endocan positively correlated with S-VCAM-1, S-IL-6, S-CRP, APACHE II and SAPS II scores and was positively associated with P-BNP in multivariate analyses. Admission S-Endocan raised in line with LVEF impairment (p = 0.008 for linear trend). Conclusion: Admission endocan significantly increases across AHF spectrum. The lack of reduction in endothelial and inflammatory markers throughout hospitalization suggests a perpetuation of endothelial dysfunction and inflammation. S-Endocan appears to be a biomarker of endothelitis and a putative therapeutic target in AHF and CS, given its association with LVEF impairment and P-BNP and its positive correlation with prognostic scores.
Identification and chemical profiling of anti-alcoholic liver disease biomarkers of ginseng Huang jiu using UPLC-Q-Orbitrap-HRMS and network pharmacology-based analyses

This study investigated the mechanism of characteristic non-volatile organic compounds (NVOCs) from ginseng Huang jiu (GH) in the treatment of alcoholic liver disease through UPLC-Q-Orbitrap-HRMS and network pharmacological analyses. Changes in NVOC contents in ginseng Huang jiu and ginseng-soaked wine fermented by different processing technologies were analyzed through liquid chromatography–mass spectrometry (LC-MS). A total of 96 ginsenosides were identified in ginseng Huang jiu throughout the fermentation process, which included 37 protopanaxadiol-type ginsenosides, 47 protopanaxatriol-type ginsenosides, and 4 oleanolic acid-type ginsenosides. Orthogonal partial least squares-discriminant analysis (OPLS-DA) revealed that 20(R)-Rg2, Gypenoside XVII, 20(S)-Rf3, CK, Rg5, Rh2, and other rare ginsenosides in ginseng Huang jiu could be the potential index for determining ginseng Huang jiu. In addition, ginseng Huang jiu could improve alcoholic liver disease by regulating the GSTP1, HRAS, AKR1B1, GSTA1, Androgen receptor (AR), GSR, and LDHB genes through bioinformatics analysis. This study provides new insights into improving the industrial production of ginseng Huang jiu and treating alcoholic liver disease with medicinal and food products.
Potential of histone deacetylase inhibitors in the control and regulation of prostate, breast and ovarian cancer

Histone deacetylases (HDACs) are enzymes that play a role in chromatin remodeling and epigenetics. They belong to a specific category of enzymes that eliminate the acetyl part of the histones’ -N-acetyl lysine, causing the histones to be wrapped compactly around DNA. Numerous biological processes rely on HDACs, including cell proliferation and differentiation, angiogenesis, metastasis, gene regulation, and transcription. Epigenetic changes, specifically increased expression and activity of HDACs, are commonly detected in cancer. As a result, HDACi could be used to develop anticancer drugs. Although preclinical outcomes with HDACs as monotherapy have been promising clinical trials have had mixed results and limited success. In both preclinical and clinical trials, however, combination therapy with different anticancer medicines has proved to have synergistic effects. Furthermore, these combinations improved efficacy, decreased tumor resistance to therapy, and decreased toxicity. In the present review, the detailed modes of action, classification of HDACs, and their correlation with different cancers like prostate, breast, and ovarian cancer were discussed. Further, the different cell signaling pathways and the structure-activity relationship and pharmaco-toxicological properties of the HDACi, and their synergistic effects with other anticancer drugs observed in recent preclinical and clinical studies used in combination therapy were discussed for prostate, breast, and ovarian cancer treatment.
Heart Rate Variability: Impact of Neuroticism and Social Isolation Heart Rate Variability: Impact of Neuroticism and Social Isolation

Psychologists are interested in self-compassion and its effects on our biopsychological well-being. A common method found throughout much research in assessing this is through heart rate variability. In the present study, we attempt to see whether or not self-compassion has an impact on one’s heart rate variability as a higher HRV indicates one is better able to adapt to stress. Self-compassion was measured beforehand through an online self-compassion survey that contained subscales measuring neuroticism. We also tested to see if social isolation would have an impact on HRV. Social isolation was implemented through a computer program game titled CyberBall , in which the researchers programmed the “game” to include or exclude the participants. There were two groups in the study with one starting in the isolation condition and ending in the non-isolation condition and the other starting in the non-isolation condition and ending in the isolation condition. Participants’ HRV was measured while they played CyberBall . We hypothesized that a lower heart rate variability would be produced during the isolation condition. We unfortunately found no significant change in HRV predicted by this hypothesis. However, our second hypothesis predicted that the more neurotic a participant was, the lower the heart rate variability would be. Results supported this hypothesis and suggest that neuroticism is an important variable when analyzing heart rate variability.
Multi-platform study of the extreme bloom of the barrel jellyfish Rhizostoma pulmo (Cnidaria: Scyphozoa) in the northernmost gulf of the Mediterranean Sea (Gulf of Trieste) in April 2021

Abstract. On 7 April 2021, an exceptional bloom of the scyphomedusa Rhizostoma pulmo was observed in the Gulf of Trieste (Italy). Blooms of this species in the northern Adriatic Sea have been reported since the late 1800s: the density of jellyfish observed in 2021 reached more than 10 specimens per square metre. We analyse the bloom from a multi-platform approach using observations and model data at different timescales. We attempt to explain the intensity of the bloom as a consequence of thermohaline and hydrodynamical conditions in the gulf. Meteo-oceanographic conditions that may have contributed to the exceptional aggregation of jellyfish observed along the northernmost coast of the Adriatic Sea are discussed in detail. Specifically, our results indicate that this bloom was enabled by (1) the presence of a high number of jellyfish in the gulf, probably linked to the anomalously warm sea conditions in spring 2020 and winter 2021, which may have favoured a longer reproductive period and enhanced survival of adult R. pulmo, respectively; and (2) strong wind events, such as the bora wind for the Gulf of Trieste, which enhanced upwelling and mixing processes in the gulf, bringing the jellyfish from the deeper waters to the surface and clustering them along the coast.
Implementation of Two Physical Layer Security Techniques in an OTA System

This paper discusses the design of two Physical Layer Security (PLS) techniques in GNU Radio. PLS is a classification of security methods that take advantage of physical properties in the waveform or channel to secure communication. These schemes can be used to directly obfuscate the signal from eavesdroppers, or even generate secret keys for traditional encryption methods. Over the past decade, advancements in Multi Input Multi Output (MIMO) systems have expanded the potential capabilities of PLS while the development of technologies such as the Internet of Things (IoT) has provided new applications. As a result, this field has become heavily researched, but is still lacking implementation. The design work covered here attempts to alleviate this issue by providing a platform for Over-The-Air (OTA) experimentation.
long-Comparative Study of Intercity Transport Companies in Benin City, Nigeria

– This study examined comparative study of intercity transport companies in Benin City, Nigeria. The study sample consists of four hundred respondents drawn from across the four leading interstate transport companies in Benin City. A questionnaire instrument was used to gather the needed information and the analytical techniques employed include simple percentage, t-test and Analysis of variance (ANOVA). All tests were performed at the 0.05 level of statistical significance. The findings revealed that God is Good Motors was rated far higher than the other transport companies by passengers while Iyare Motors was rated the least. Furthermore, we found that there is no significant relationship between respondents’ gender and customer perception of service quality in interstate transport companies. However, educational qualification and age had a significant relationship with passengers’ perception of service quality. We recommend that interstate transport companies should concentrate more on issues such as safety, comfort on the road, respect for passengers and regular maintenance of vehicles as well as replacing unserviceable vehicles with new ones to avoid frequent vehicle breakdown on the highway.
Some Geometric And Physical Properties Of Generalized Peres Space-Time

In this paper we have investigated some geometric and physical properties of generalized Peres space-time P* in the sense of Takeno (1961) and made some discussions. Keywords - General relativity,plane fronted waves, Ricci tensor, curvature tensor, electromagnetic energy momentum tensor, co-ordinate condition,phase velocity, energy momentum pseudo tensors,parallel vector field vi etc.
Large-scale outﬂows in luminous QSOs revisited The impact of beam smearing on AGN feedback efﬁciencies

Context. Feedback from active galactic nuclei (AGN) is thought to play an important role in quenching star formation in galaxies. However, the e ﬃ ciency with which AGN dissipate their radiative energy into the ambient medium remains strongly debated. Aims. Enormous observational e ﬀ orts have been made to constrain the energetics of AGN feedback by mapping the kinematics of the ionized gas on kpc scale. We study how the observed kinematics and inferred energetics are a ﬀ ected by beam smearing of a bright unresolved narrow-line region (NLR) due to seeing. Methods. We re-analyse optical integral-ﬁeld spectroscopy of a sample of twelve luminous unobscured quasi-stellar objects (QSOs) (0 . 4 < z < 0 . 7) previously presented in the literature. The point-spread function (PSF) for the observations is directly obtained from the light distribution of the broad H β line component. Therefore, we are able to compare the ionized gas kinematics and derived energetics of the total, truly spatially extended, and unresolved [O iii ] emission. Results. We ﬁnd that the spatially resolved [O iii ] line width on kpc scales is signiﬁcantly narrower than the one before PSF deblending. The extended NLRs (ENLRs) appear intrinsically o ﬀ set from the QSO position or more elongated which can be interpreted in favour of a conical outﬂow on large scales while a spherical geometry cannot be ruled out for the unresolved NLR. We ﬁnd that the kinetic power at 5 kpc distance based on a spherical model is reduced by two orders of magnitude for a conical outﬂow and one order of magnitude for the unresolved NLR after PSF deblending. This reduced kinetic power corresponds to only 0.01 − 0.1 per cent of the bolometric AGN luminosity. This is smaller than the 5 − 10% feedback e ﬃ ciency required by some cosmological simulations to reproduce the massive galaxy population. The injected momentum ﬂuxes are close or below the simple radiation-pressure limit L bol / c for the conical outﬂow model for the NLR and ENLR when beam smearing is considered. Conclusions. Integral-ﬁeld spectroscopy is a powerful tool to investigate the energetics of AGN outﬂows, but the impact of beam smearing has to be taken into account in the high contrast regime of QSOs. For the majority of observations in the literature, this has not been addressed carefully so that the incidence and energetics of presumed kpc-scale AGN-driven outﬂows still remain an unsolved issue, from an observational perspective.