Miracle-dz/UniFAR-FTUs huggingface dataset:
A Novel CVAE-Based Sequential Monte Carlo Framework for Dynamic Soft Sensor Applications

In industrial processes, quality variables are typically sampled at a considerably lower frequency than system inputs due to technical or cost constraints. Dynamic soft sensors utilize temporal prediction to bridge these sampling gaps, thus enabling real-time closed-loop control. However, existing approaches primarily focus on one-step prediction accuracy, potentially leading to significant deviations in long-term predictions. In addition, these methods are incapable of evaluating the reliability of prediction results, subsequently increasing the potential risk of closed-loop systems. To tackle these challenges, this study presents a novel regression modeling approach based on the conditional variational autoencoder (CVAE) framework. In contrast to traditional regression approaches, this method focuses on modeling the transition probability distribution of the system, allowing the model to produce a range of credible quality variable predictions via Monte Carlo (MC) sampling. Based on the CVAEs, the sequential MC method is further employed to simulate diverse potential system state trajectories, thereby achieving multistep soft measurement prediction. Compared with traditional soft measurement techniques, the proposed method demonstrates lower prediction biases and the capacity to assess the credibility of prediction results from a probabilistic standpoint. When online quality variables are assessed by the laboratory, this method can update predictions utilizing the resampling scheme. Two case studies are offered to validate the effectiveness of the proposed scheme.
Communication With the Social Environment in Multiplayer Online Games

The process of massive multiplayer online gamers and their social environment is analyzed in this context. Video games offer a platform for players to develop essential social and emotional skills with online gamers, such as predicting behaviors, providing support, and building relationships. Gaming serves as a communication channel, and games played in groups promote increased socialization instead of isolating individuals. Supporting each other during gameplay strengthens friendships, and MMOs ensure that ties with old friends are not broken. Multiplayer games can help players form lasting social connections and memories by fostering a positive and enjoyable gaming experience. Through shared experiences, players can form close bonds and support each other in difficult situations. Online gaming enables individuals who have never met face-to-face to establish strong and meaningful friendships. Players may be meticulous when recruiting people to their group to ensure that they are skilled, friendly, trustworthy, and will enhance their gaming experience.
Editorial: Role of non-coding RNAs in development and metastasis of solid tumours

Non-coding RNAs (ncRNAs) including long non-coding RNAs (lncRNAs), micro RNAs (miRNAs), and circular RNAs (circRNAs) are emerging as key players in regulating tumorigenesis. Though these ncRNAs do not encode for functional proteins, they can act epigenetically, transcriptionally, post transcriptionally or at translational and post translational levels to alter gene expression. Accumulating evidence suggests that lncRNAs alter gene expression during the development and metastasis of solid tumors. Importantly, these non-coding RNAs are also used as biomarkers in different cancers. This special edition presents a wide Research Topic of reviews that summarize recent work in this area. CircRNAs are generated by back splicing from covalently closed loops. The first circRNAwas reported in virus (Kolakofsky, 1976; Sanger et al., 1976). Three years later, circRNAs were identified in the cytoplasm of several eukaryotic cells by electron microscopy by Hsu and CocaPrados (1979). With the advancement of high throughput sequencing and bioinformatics, indepth analysis, and characterization of circular RNAs have been emerging. CircRNAs usually are more stable than linear ones and can be translated into small peptides through cap-independent manner. The recently identified approximately 1,500 circular RNA in mouse or rat genomes unravel the possibility of the identification of peptides. In humans, the first circRNAwas detected in Hela cells in 1979. After that, various functions of circular RNAs have been implicated in a number of diseases and disorders such as diabetes, neurological disorders, cardiovascular diseases, and cancer. In cancer, multiple studies suggest that peptides synthesized from the circRNA, play a critical role in proliferation, invasion and migration of various cancer cells. Recently, a circRNA produced by the SNF2 histone linker PHD RING helicase (SHPRH) gene was reported to be associated with various cancers including lung, bladder, liver, and colorectal cancers, and glioma. The review article by Xiong et al. summarizes the role of circ-SHPRE in regulating gene expression in tumorigenesis and as a prognostic biomarker for the early detection of various solid cancers. LncRNAs regulate the expression of genes post-transcriptionally. LncRNAs can also modulate nuclear organization, mRNA processing, and protein activities and thus are known OPEN ACCESS
Climate change in the European Alps : adapting winter tourism and natural hazards management

Climate change poses a serious challenge to social and economic development in all countries. While international commitments to reduce greenhouse gas emissions are essential, adaptation to the impacts of climate change must also be integrated into sectoral and economic policies worldwide. This volume examines the implications of climate change for the economies in the European Alps. It focuses on adaptation measures to address two key vulnerabilities: increasing losses in winter tourism due to reduced snow cover, and increased exposure of settlements and infrastructure to natural hazards.
Biomechanical Analysis of Latin Dancers’ Lower Limb during Normal Walking

Latin dance involves fundamental walking steps, integral to the dance process. While resembling daily walking, Latin dance demands higher balance levels, necessitating body adjustments by dancers. These adaptations affect dancers’ gait biomechanics, prompting our study on gait differences between Latin dancers (LDs) and non-dancers (NDs). We enlisted 21 female Latin dancers and 21 subjects based on specific criteria. Participants executed walking tasks, with an independent sample t-test for 1-dimensional statistical parameter mapping (SPM 1d) analyzing stance phase variations between LDs and NDs. Notably, significant differences in ankle and hip external rotation were evident during the 16.43–29.47% (p = 0.015) and 86.35–100% (p = 0.014) stance phase. Moreover, pronounced distinctions in rectus Achilles tendon force (ATF) (12.83–13.10%, p = 0.049; 15.89–80.19%, p < 0.001) and Patellofemoral joint contact force (PTF) (15.85–18.31%, p = 0.039; 21.14–24.71%, p = 0.030) during stance were noted between LDs (Latin dancers) and NDs (Non-dancers). The study revealed dancers’ enhanced balance attributed to external ankle rotation for dance stability, coupled with augmented Achilles tendon and patellofemoral joint strength from prolonged practice. Moreover, integrating suitable Latin dance into rehabilitation may benefit those with internal rotation gait issues.
Heavy metals distribution in superficial sediments of Maracaibo Lake (Venezuela)

Ni, V, Cr, Cd, Cu and Pb were determined in superficial sediment samples from System Maracaibo Lake. Thirteen sampling points were sampled in Tablazo bay, Maracaibo Strait and Maracaibo Lake, four times during 2 years as follows: October 1999 (rainy season), March 2000 (dry season), November 2000 (rainy season) and May 2001 (low rainy period). Mean values (minimum-maximum) of heavy metals were: Cu: 27,07 (2,31-75,46), Cd: 3,37 (0,46-7,9), Cr: 39,50 (3,98-98,28), Pb: 60,59 (17,8-143,9), V: 50,44 (1,29-121,2) y Ni: 65,31 (16,76-177,62) mg.Kg–1. The metal concentrations present in sediments were in the following order: Ni > Pb > V > Cr > Cu > Cd. Metal concentration in sediments of Maracaibo Lake system, are similar to the aquatic systems with a high oil activity. Samples showed a clear tendency to higher values in the eastern area of Maracaibo Lake and lower value in the western zone.
Primary bone and dinosaurian physiology

Abstract Primary compact bone is ignored in some recent discussions of claims that dinosaurs were endotherms, but forms the basis of one of the arguments from bone, and part of the basis of another. This paper explains its histology and discusses its possible significance. In dinosaurs the primary compact bone was commonly fibre-lamellar bone, resembling bone seen in many large mammals, and implying a capacity to sustain rapid growth to large sizes. This probably indicates some physiological difference between dinosaurs and modern types of reptiles; but similar bone is present in early therapsids, which were probably not endotherms, and bone with typical reptilian ‘growth rings’ was sometimes formed. Endothermy is also unlikely in most kinds of dinosaurs, if its evolution requires a trend to small sizes; but perhaps they were ‘failed endotherms’.
Mountain Timberlines—Ecology, Patchiness, And Dynamics

From the Table of Contents Preface. - Acknowledgements. -1 Introduction. - 2 History and present state of timberline research. - 3 Definitions, terminology. - 4 Physiognomic and ecological differentiation of mountain timberline. - 5 Timberline fluctuations. - 6 Timberline prospects and research needs. - References. - Index
Forcing of late Cenozoic northern hemisphere climate by plateau uplift in southern Asia and the American west

Geologic evidence indicates that net vertical uplift occurred on a large (kilometer) scale and at accelerating rates during the middle and late Cenozoic in plateaus of southern Asia and the American west. Based on this evidence, General Circulation Model sensitivity tests were run to isolate the unique effects of plateau uplift on climate. The experiments simulated significant climatic changes in many places, some far from the uplifted regions. The basic direction of most of these simulated responses to progressive uplift is borne out by changes found in the geologic record: winter cooling of North America, northern Europe, northern Asia, and the Arctic Ocean; summer drying of the North American west coast, the Eurasian interior, and the Mediterranean; winter drying of the North American northern plains and the interior of Asia; and changes over the North Atlantic Ocean conducive to increased formation of deep water. The modeled changes result from increased orographic diversion of westerly winds, from cyclonic and anticyclonic surface flow induced by summer heating and winter cooling of the uplifted plateaus, and from the intensification of vertical circulation cells in the atmosphere caused by exchanges of mass between the summer-heated (and winter-cooled) plateaus and the mid-latitude oceans. Disagreements between the geologic record and the model simulations in Alaska and the Southern Rockies and plains may be related mainly to the lack of narrow mountain barriers in the model orography. Taken together, the observed regional trends comprise much of the pattern of “late Cenozoic climatic deterioration” in the northern hemisphere that culminated in the Plio-Pleistocene ice ages. The success of the uplift sensitivity experiment in simulating the correct pattern and sign of most of the observed regional climatic trends points to uplift as an important forcing function of late Cenozoic climatic change in the northern hemisphere at time scales longer than orbital variations; however, the modest amplitude of the uplift-induced cooling simulated at high latitudes indicates a probable need for additional climatic forcing.
Glaucony from the Eocene of the Isle of Wight (southern UK): implications for basin analysis and sequence-stratigraphic interpretation

The Lower-Middle Eocene sequence of the Hampshire Basin, which includes an alternation of sands, silts and clays, interpreted as fluvial to open-marine deposits, is exposed at two locations on the western (Alum Bay) and eastern (Whitecliff Bay) margin of the Isle of Wight. Glaucony is encountered throughout the study units: sand-clay alternations of lagoonal origin and estuarine channel-fill sands include less than 10% of predominantly poorly evolved, allochthonous glaucony; shelf silts and sands generally comprise more than 20% of evolved, mostly autochthonous glaucony. Vertical changes in maturity of glaucony confirm the trend predicted by recent models, indicating an overall upward increase in the transgressive systems tracts and decrease in the highstand systems tracts, with maximum values in coincidence with the condensed sections, where a remarkable peak in glaucony concentration is invariably recorded. Comparison of glaucony characteristics at different sites of depositional sequences shows a slight increase in maturity and abundance from the proximal to the distal areas. This lateral tendency is interpreted to reflect more suitable conditions for glauconitization in open-marine environments than in shallow waters. Despite documented intrasequential variability of glaucony characteristics, glaucony assemblages from distinct depositional sequences may be generally identified on the basis of more pronounced differences in maturity. Consequently, glaucony attributes can be used as an index for characterization of third-order sedimentary cycles.
3DRA: Dynamic Data-Driven Reconfigurable Architecture

Specialized accelerators are becoming a standard way to achieve both high-performance and efficient computation. We see this trend extending to all areas of computing, from low-power edge-computing systems to high-performance processors in datacenters. Reconfigurable architectures, such as Coarse-Grained Reconfigurable Arrays (CGRAs), attempt to find a balance between performance and energy efficiency by trading off dynamism, flexibility, and programmability. Our goal in this work is to find a new solution that provides the flexibility of traditional CPUs, with the parallelism of a CGRA, to improve overall performance and energy efficiency. Our design, the Dynamic Data-Driven Reconfigurable Architecture (3DRA), is unique, in that it targets both low-latency and high-throughput workloads. This architecture implements a dynamic dataflow execution model that resolves data dependencies at run-time and utilizes non-blocking broadcast communication that reduces transmission latency to a single cycle to achieve high performance and energy efficiency. By employing a dynamic model, 3DRA eliminates costly mapping algorithms during compilation and improves the flexibility and compilation time of traditional CGRAs. The 3DRA architecture achieves up to 731MIPS/mW, and it improves performance by up to 4.43x compared to the current state-of-the-art CGRA-based accelerators.
Benefits of Engaging Head Start Parents in Emotion Socialization Practices

Developing social-emotional skills can improve children's happiness, experiences, and ability to establish positive relationships. Children from low-income families experience higher risk factors than their middle- and upper-class counterparts. Hence, fostering these skills early at home and in the classroom is essential. Past research demonstrates various interventions to reduce problem behaviors and improve emotional socialization in children, as well as the impact of educating parents on effective emotion socialization practices. Tuning in to Kids Online (TIKOL) is an emotion socialization parenting program aiming to support parents' understanding of children's social-emotional development and employ an emotion coaching style to help children understand, label, and regulate their emotions. This study examined the engagement, effectiveness, and acceptability of TIKOL in a small sample of Head Start parents. Findings support the use of TIKOL to improve parents' emotion coaching practices, reduce parents' distressing reactions to children's behavior, and reduce parent-reported child conduct problems.
Pangenome-level analysis of nucleoid-associated proteins in the Acidithiobacillia class: insights into their functional roles in mobile genetic elements biology

Mobile genetic elements (MGEs) are relevant agents in bacterial adaptation and evolutionary diversification. Stable appropriation of these DNA elements depends on host factors, among which are the nucleoid-associated proteins (NAPs). NAPs are highly abundant proteins that bind and bend DNA, altering its topology and folding, thus affecting all known cellular DNA processes from replication to expression. Even though NAP coding genes are found in most prokaryotic genomes, their functions in host chromosome biology and xenogeneic silencing are only known for a few NAP families. Less is known about the occurrence, abundance, and roles of MGE-encoded NAPs in foreign elements establishment and mobility. In this study, we used a combination of comparative genomics and phylogenetic strategies to gain insights into the diversity, distribution, and functional roles of NAPs within the class Acidithiobacillia with a special focus on their role in MGE biology. Acidithiobacillia class members are aerobic, chemolithoautotrophic, acidophilic sulfur-oxidizers, encompassing substantial genotypic diversity attributable to MGEs. Our search for NAP protein families (PFs) in more than 90 genomes of the different species that conform the class, revealed the presence of 1,197 proteins pertaining to 12 different NAP families, with differential occurrence and conservation across species. Pangenome-level analysis revealed 6 core NAP PFs that were highly conserved across the class, some of which also existed as variant forms of scattered occurrence, in addition to NAPs of taxa-restricted distribution. Core NAPs identified are reckoned as essential based on the conservation of genomic context and phylogenetic signals. In turn, various highly diversified NAPs pertaining to the flexible gene complement of the class, were found to be encoded in known plasmids or, larger integrated MGEs or, present in genomic loci associated with MGE-hallmark genes, pointing to their role in the stabilization/maintenance of these elements in strains and species with larger genomes. Both core and flexible NAPs identified proved valuable as markers, the former accurately recapitulating the phylogeny of the class, and the later, as seed in the bioinformatic identification of novel episomal and integrated mobile elements.
Frequency dependent polarization analysis of high‐frequency seismograms

We present a multitaper algorithm to estimate the polarization of particle motion as a function of frequency from three-component seismic data. This algorithm is based on a singular value decomposition of a matrix of eigenspectra at a given frequency. The right complex eigenvector zˆ corresonding to the largest singular value of the matrix has the same direction as the dominant polarization of seismic motion at that frequency. The elements of the polarization vector zˆ specify the relative amplitudes and phases of motion measured along the recorded components within a chosen frequency band. The width of this frequency band is determined by the time-bandwidth product of the prolate spheroidal tapers used in the analysis. We manipulate the components of zˆ to determine the apparent azimuth and angle of incidence of seismic motion as a function of frequency. The orthogonality of the eigentapers allows one to calculate easily uncertainties in the estimated azimuth and angle of incidence. We apply this algorithm to data from the Anza Seismic Telemetered Array in the frequency band 0 ≤ ƒ ≤ 30 Hz. The polarization is not always a smooth function of frequency and can exhibit sharp jumps, suggesting the existence of scattered modes within the crustal waveguide and/or receiver site resonances.
Checklist of the Upper Guinea forest area climbers of Côte d\'Ivoire

From a vascular plant database of Cote d\'Ivoire, 8502 records regarding 758 taxa that consist of 727 species and 31 infraspecific taxa, 258 genera and 63 families of humid forest area climbers were extracted. Taxa which occur commonly in the Upper Guinea forest area of Cote d\'Ivoire including the coastal forests, the lowland evergreen forests, the semi-deciduous forests and the montane forests had been taken in account in this survey. Their biologic types and phytochories were furnished De la base de donnees sur les plantes vasculaires de la Cote d\'Ivoire, 8502 saisies relatives a 758 taxons repartis entre 727 especes et 31 taxons infraspecifiques, 258 genres et 63 familles de lianes de la zone de foret dense humide ont ete extraites. Les taxa distribues frequemment dans les forets denses de la Haute Guinee, au niveau de la Cote d\'Ivoire, constituees par les forets cotieres, les forets sempervirentes de basses altitudes, les forets denses semidecidues et les forets montagnardes ont ete pris en compte dans cette etude. Leurs types biologiques et les phytochories ont ete fournis. Keywords : climbers, taxa, Upper Guinea forest area, Cote d\'Ivoire. /lianes, taxons, zone de forets de la Haute Guinee, Cote d\'Ivoire. Sciences & Nature Vol. 4 (2) 2007: pp. 149-169
Neuroblastoma in the Era of Precision Medicine: A Clinical Review

Simple Summary Patients with high-risk neuroblastoma, especially those whose disease either does not respond or recurs, have a poor chance of survival. Additionally, the majority of survivors of modern day high-risk neuroblastoma therapy develop significant late-effects. In an effort to improve survival, new agents with less toxicity are being explored. As technologies advance, the ability to design therapies for specific molecular targets on neuroblastoma are crucial. The most notable existing targeted therapies for high-risk neuroblastoma thus far are ALK inhibitors and anti-GD2 therapies, both of which have become mainstays of treatment both in the upfront and relapsed settings. Development of additional molecular targeted therapy has proven challenging, with limited successes. Adding to this difficulty is the heterogeneity of high-risk neuroblastoma, especially in the relapsed setting. This heterogeneity makes the numbers of patients eligible for specific targeted therapy small, complicating optimal clinical trial design. Here, we review the known molecular targets of neuroblastoma and their clinical implications. Abstract The latest advances in treatment for patients with neuroblastoma are constantly being incorporated into clinical trials and clinical practice standards, resulting in incremental improvements in the survival of patients over time. Survivors of high-risk neuroblastoma (HRNBL), however, continue to develop treatment-related late effects. Additionally, for the majority of the nearly 50% of patients with HRNBL who experience relapse, no curative therapy currently exists. As technologies in diagnostic and molecular profiling techniques rapidly advance, so does the discovery of potential treatment targets. Here, we discuss the current clinical landscape of therapies for neuroblastoma in the era of precision medicine.