Miracle-dz/UniFAR-FTUs huggingface dataset:
Measurement of sub-fm/Hz1/2 displacement spectral densities in ultrahigh-Q single-crystal microcavities with Hz-level lasers

Tracing a resonance frequency of a high quality factor ( Q ) optical cavity facilitates subpicometer displacement measurements of the optical cavity via Pound – Drever – Hall (PDH) locking scheme, tightly synchronizing a laser frequency to the optical cavity. Here we present observations of subfemtometer displacements on a ultrahigh-Q single-crystal MgF 2 whispering-gallery-mode microcavity by frequency synchronization between a 1 Hz cavity-stabilized laser and a resonance of the MgF 2 cavity using PDH laser-cavity locking. We characterize not only the displacement spectral density of the microcavity with a sensitivity of 1 . 5 × 10 − 16 m ∕ Hz 1 ∕ 2 over the Fourier offset frequency ranging from 15 mHz to 100 kHz but also a 1.77 nm displacement fluctuation of the microcavity over 4500 s. Such measurement capability not only supports the analysis of integrated thermodynamical and technical cavity noise but allows for minute displacement measurements using laser-cavity locking for ultraprecise positioning, metrology, and sensing.
PHYTIC ACID CONTENT AND DIGESTIBILITY OF COCONUT RESIDUES DERIVED-PROTEINS AFTER SOLID-STATE FERMENTATION BY Aspergillus awamori

The growing industry of aquaculture is in demand of alternative protein sources as fish feeds. An adequate amount of digestible protein and the presence of anti-nutritional such as phytic acid factors are limiting factors in feed formulations. One alternative source of protein for fish feeds is fermented coconut residues. However, the phytic acid content, an anti-nutrient compound produced during the bioconversion or fermentation process of agriculture waste has not yet been determined. Therefore, the objective of the present study was to determine the phytic acid content and protein digestibility of coconut residues after solid-state fermentation (SSF) by Aspergillus awamori. Samples from three optimized fermentation conditions were analyzed for soluble proteins, phytic acid contents, and in-vitro digestibility activity by trypsin and pepsin. Results showed that phytic acid content in all samples were lower than 0.1 mg/g dry wt. of the sample after seven days of fermentation. The protein digestibility by trypsin (ranging from 36.54 ± 4.22 to 43.22 ± 2.46%) was higher than pepsin, where it fell within the percentage required for fish feed formulation. The findings suggested that fermented coconut residues are a highly potential alternative source of protein for fish feed formulation.
CD82 palmitoylation site mutations at Cys5+Cys74 affect EGFR internalization and metabolism through recycling pathway

Tetraspanin CD82 often participates in regulating the function of epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (c-Met). Palmitoylation is a post-translational modification that contributes to tetraspanin web formation and affects tetraspanin-dependent cell signaling. However, the molecular mechanisms by which CD82 palmitoylation affects the localization and stability of EGFR and c-Met have not yet been elucidated. This study focuses on the expression and distribution of EGFR and c-Met in breast cancer as well as the related metabolic pathways and molecular mechanisms associated with different CD82 palmitoylation site mutations. The results show that CD82 with a palmitoylation mutation at Cys5+Cys74 can promote the internalization of EGFR. EGFR is internalized and strengthened by direct binding to CD82 with the tubulin assistance and located at the recycling endosome. After studying the recycling pathway marker proteins Rab11a and FIP2, we found that formation of the EGFR/CD82/Rab11a/FIP2 complex promotes the internalization and metabolism of EGFR through the recycling pathway and results in the re-expression of EGFR and CD82 on the cell membrane.
Biomagnetic techniques for evaluating gastric emptying, peristaltic contraction and transit time

Biomanetic techniques were useto measure motility inarious parts of theastrointestinal (GI) tract, partic- ularly a new technique foretectinmanetic markers antracers. A coil was useto enhance the sinal from a manetic tracer in the GI tract anthe sinal was detected using a fluxgate magnetometer or a magne - toresistor in an unshieleroom. Estimates of esopha- �eal transit time were affecteby the position of the subject. �he reproucibility of estimateserieusin� the new biomanetic technique wasreater than 85% anit yieleestimates similar to those obtaineusin� scintiraphy. �his technique is suitable for stuyinthe effect of emotional state on GI physioloy anfor mea- surinGI transit time. �he biomanetic technique can be useto ealuateiesta transit time in the esopha- �us, stomach ancolon, peristaltic frequency an� �as- tric emptyinanis easy to use in the hospital settin�.
High-Order Current Transfer Function Synthesis Using Translinear Current-Conveyors

Using the signal-flow graph approach, a synthesis procedure for generating high-order current transfer functions using the translinear plus-type current-follower second-generation current-conveyor (CFCCII p ) is presented. The proposed circuit can simultaneously support n + 2 high-impedance output currents. By joining appropriate output currents, the circuit can support a wide range of current transfer-functions.
Nailfold Capillaroscopic Changes as a Marker of Interstitial Lung Disease in Systemic Sclerosis: A Cross-Sectional Study in a Tertiary Care Hospital in Eastern India

Background: Systemic sclerosis (SSc) is an autoimmune connective tissue disorder causing microvascular abnormality leading to Raynaud's phenomenon, skin tightening, and nailfold capillary changes. The patient may have systemic involvement, among them interstitial lung disease (ILD) and pulmonary arterial hypertension are mainly associated with disease-related mortality. Aims: To find out an association between nailfold capillaroscopic changes with ILD severity. Materials and Methods: An institution based cross-sectional study was performed among the patients of SSc above 18 years. Detailed history was taken. Clinical examinations, nailfold capillaroscopy (NFC) with a dermatoscope and high-resolution computed tomography (HRCT) scan of thorax were done. Data were analyzed in MedCalc statistical software version 20. Results: Out of total 43 patients, 74.4% (n = 32) were female. Mean age was 35.05 ± 7.24 years and mean duration 4.28 ± 2.81 years. Diffuse SSc was found in 88.37% (n = 38). On NFC, early, active, and late patterns were found in 30.2% (n = 13), 25.6% (n = 11), and 44.2% (n = 19) cases, respectively. On HRCT, early, active, and late ILD were present in 18.6% (n = 8), 37.2% (n = 16), and 30.2% (n = 13) cases, respectively. ILD changes were absent in 14% (n = 6) though NFC changes were present in them. Respiratory symptoms were absent in 20.93% (n = 9) patients though all had features of early NFC and among them 9.3% (n = 4) showed early ILD changes on HRCT. Significant associations were found between NFC changes and ILD severity (P = 0.0003), NFC changes and respiratory symptoms (P < 0.0001) and between ILD changes and respiratory symptoms (P < 0.0001). Discussion: NFC, an inexpensive procedure, can be performed in all patients of SSc to detect development of early ILD even before appearance of respiratory symptoms to prevent further progression.
Intelligent Crack Detection and Quantification in the Concrete Bridge: A Deep Learning-Assisted Image Processing Approach

We proposed a modified concrete bridge crack detector based on a deep learning-assisted image processing approach. Data augmentation technology is introduced to extend the limited dataset. In our proposed method, the bounding box for the crack is detected by YOLOv5. Then, the image covered by the bounding box is processed by the image processing techniques. Compared with the conventional image processing-based crack detection method, the deep learning-assisted image processing approach leads to higher detection accuracy and lower computation cost. More precisely, the mask filter is employed to remove handwritten marks, and the ratio filter is adopted to eliminate speckle linear noises. When a single crack is detected by several bounding boxes, we proposed a novel fusion method to merge these bounding boxes. Furthermore, we proposed a connected component search approach based on the crack trend of the area to improve the connection accuracy. With the crack detector, the cracks that are wider than 0.15 mm can be correctly detected, quantified, and visualized. The detection absolute error of the crack width is less than 0.05 mm. Thus, we realized fast and precise detection and quantification of bridge crack based on the practical engineering dataset.
Kekuatan Authenticity pada makanan local tradisional serta hubungannya dengan pride dan loyalty Gen Milenial

ABSTRAK Tujuan penelitian – Munculnya berbagai brand ­­global yang menawarkan makanan yang berasal dari Negara lain di berbagai daerah di Jawa Timur mulai menarik bagi konsumen khususnya generasi milenial. Hal ini tentu menjadi pekerjaan rumah baik bagi pelaku bisnis juga pemerintah dalam mempertahankan kelestarian makanan local tradisional (MLT) agar tetap eksis dan disukai oleh konsumen khususnya masyarakat local sebagai “pemilik” budaya dan tradisi setempat. Authenticity merupakan satu kekuatan yang dimiliki MLT yang sulit untuk diimplementasikan secara maksimal oleh brand makanan global. Penelitian ini berfokus untuk menyelidiki pengaruh authenticity yang mengarah pada perasaan emosional generasi millenial berupa pride dan loyalitasnya terhadap MLT dibandingkan dengan makanan global. Desain/Metodologi/Pendekatan – Jenis penelitian ini adalah eksplanatori yang bertujuan untuk menganalisis hubungan antara authenticity MLT, pride, serta loyalty. Sampel pada penelitian ini sebanyak 200 responden milenial kelahiran tahun 1980-2000 yang berdomisi di Jawa Timur, Indonesia. Pendekatan Variance Based SEM dengan alat analisis smartPLS 3.0 digunakan dalam penelitian. Temuan – Hasil analisis menunjukkan bahwa authenticity secara langsung berpengaruh signifikan pada loyalty dan pride. Selanjutnya, variable pride juga secara signifikan mempengaruhi loyalty kuliner local tradisional pada konsumen milenial di Jawa Timur. Selain itu, pride sebagai reaksi emosional yang dirasakan konsumen mampu memediasi secara partial hubungan antara authenticity dan loyalty. Keterbatasan penelitian – Dinamika konsumen terhadap MLT tentu memerlukan penyelidikan lebih lanjut terkait dengan faktor-faktor pendorongnya. Tidak hanya terbatas pada authenticity, pride dan loyalty pada konsumen local, variable lain serta responden dari luar wilayah bisa peluang bagi penelitian selanjutnya. Originality/value – Studi ini mengungkapkan kekuatan strategi authenticity MLT saat bersaing dengan merek makanan global sebagai upaya pelestarian budaya local. Untuk mendapatkan manfaat yang berkelanjutan, MLT perlu meningkatkan pride dan loyalitas konsumen yang secara tidak langsung berguna sebagai agen promosi MLT baik pada masyarakat domestic maupun wisatawan manca Negara.Keywords : Authenticity, Pride, Loyalty, Local Food
Ultrasonic Omics Based on Intelligent Classification Algorithm in Hormone Receptor Expression and Efficacy Evaluation of Breast Cancer

The changes of hormone expression and efficacy of breast cancer (BC) were investigated under the VGG19FCN algorithm and ultrasound omics. 120 patients with BC were selected, of which 90 were positive for hormone receptor and 30 were negative. The VGG19FCN model algorithm and classifier were selected to classify the features of ultrasound breast map, and reliable ultrasound feature data were obtained. The evaluation and analysis of BC hormone receptor expression and clinical efficacy in patients with BC were realized by using ultrasonic omics. The evaluation of the results of the VGG19FCN algorithm was DSC (Dice similarity coefficient) = 0.9626, MPA (mean pixel accuracy) = 0.9676, and IOU (intersection over union) = 0.9155. When the classifier was used to classify the lesion features of BC image, the sensitivity of classification was improved to a certain extent. Compared with the classification of radiologists, when classifying whether patients had BC lesions, the sensitivity increased by 22.7%, the accuracy increased from 71.9% to 79.7%, and the specific evaluation index increased by 0.8%. No substantial difference was indicated between RT (arrive time), WIS (wash in slope), and TTP (time to peak) before and after chemotherapy, P > 0.05. After chemotherapy, the AUC (area under curve) and PI (peak intensity) of ultrasonographic examination were substantially lower than those before chemotherapy, and there were substantial differences in statistics (P < 0.05). In summary, the VGG19FCN algorithm effectively reduces the subjectivity of traditional ultrasound images and can effectively improve the value of ultrasound image features in the accurate diagnosis of BC. It provides a theoretical basis for the subsequent treatment of BC and the prediction of biological behavior. The VGG19FCN algorithm had a good performance in ultrasound image processing of BC patients, and hormone receptor expression changed substantially after chemotherapy treatment.
Addressing the Needs of the Rapidly Aging Society through the Development of Multifunctional Bioactive Coatings for Orthopedic Applications

The unprecedented aging of the world’s population will boost the need for orthopedic implants and expose their current limitations to a greater extent due to the medical complexity of elderly patients and longer indwelling times of the implanted materials. Biocompatible metals with multifunctional bioactive coatings promise to provide the means for the controlled and tailorable release of different medications for patient-specific treatment while prolonging the material’s lifespan and thus improving the surgical outcome. The objective of this work is to provide a review of several groups of biocompatible materials that might be utilized as constituents for the development of multifunctional bioactive coatings on metal materials with a focus on antimicrobial, pain-relieving, and anticoagulant properties. Moreover, the review presents a summary of medications used in clinical settings, the disadvantages of the commercially available products, and insight into the latest development strategies. For a more successful translation of such research into clinical practice, extensive knowledge of the chemical interactions between the components and a detailed understanding of the properties and mechanisms of biological matter are required. Moreover, the cost-efficiency of the surface treatment should be considered in the development process.
Adjuvant osimertinib treatment in patients with early stage NSCLC (IB-IIIA): pathological pathway adaptations

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Around 30% of patients are diagnosed with early disease and 60% after the tumour has spread to a different part of the body. The earlier NSCLC is diagnosed, the better the chances of prolonging survival. Recent years have seen striking improvements in cancer treatment outcomes through increased use of molecular diagnostics. Therapy decisions are now based on a combination of genetic testing and genetically matched targeted therapies. The positive results obtained with the use of tyrosine kinase inhibitors (TKIs), including osimertinib, in the metastatic disease, coupled with recent data in early stage disease support the importance of molecular testing in this setting. In this overview we discuss factors paramount in pathological pathways to ensure optimal management of early stage NSCLC and also provide an overview of requirements/recommendations. Critical issues in the pre-analytical phases regarding both cytology/biopsy samples and surgically resected tissues are highlighted and solutions are proposed to guarantee accuracy, adequacy and sustainability in the innovative approach to be introduced in clinical practice for NSCLC patients.
Effect of CO2 laser (9.3 μm) irradiation and AmF/NaF/SnCl2 solution in prevention and control of erosive tooth wear, an in-situ study

Objectives: The cross-over in-situ study aimed to evaluate the effect of CO2 laser (9.3μm) irradiation, in combination with an AmF/NaF/SnCl2 rinse on prevention and control of Erosive Tooth Wear (ETW) in human enamel. Materials and Methods: Two different settings were tested with, 1) as ETW-prevention (starting from sound tooth surfaces) (Setting-1), and 2) as ETW-control (substrates presented at start an artificial erosive lesion) (Setting-2). Additionally, in in one subset samples were exposed to AmF/NaF/SnCl2 solution (Phase I) while in the other no exposure to the Fluoridetin rinse occurred (Phase). 192 samples of human enamel (3x3x1mm) were randomly divided into 4 experimental groups: (C) without treatment (negative control); (F) AmF/NaF/SnCl2 solution (positive control); (L) CO2 laser irradiation; (L+F) CO2 laser+AmF/NaF/SnCl2 solution. 12 volunteers wearing removable devices participated in the study, carrying 8 samples per device. The erosive challenges (4×5min/day) occurred ex-vivo. The surface loss over time was measured using an optical profilometer (n=12 per group). Setting-1 data were analyzed by one-way ANOVA and Setting-2 data by two-way repeated measures ANOVA, both with Tukey post-hoc tests (α=5%). Results: Setting-1: groups L (4.59 ±2.95μm) and L+F (1.58±1.24μm) showed significantly less surface loss in preventing ETW than groups C and F. Setting-2: in controlling the progression of ETW, L+F was the only group with no significant surface loss between initial erosive lesion (3.65 ±0.16μm) and after erosive challenge (4.99 ±1.17μm). Conclusions: CO2 9. 3μm laser application prevented and controlled ETW progression in human enamel, with greater efficiency when combined with AmF/NaF/SnCl2 solution application. *
English in Bilingual Promotional Material of Chinese Maritime-related Exhibition Publicity: A discourse Analysis Study

In recent years, the numbers of bilingual advertising texts have increased in China’s international maritime exhibitions. Nevertheless, the shortcomings in wording and phrasing, usage of translation strategies and intercultural communication in these China English texts are not only contrary to the Plain English Movement which advocated a more concise and economical use of words and sentences in the late 20th century, but also adversely affect the Belt and Road Initiative as well as intercultural communication. In this paper, various promotional material collected from major maritime-related English exhibitions in China over the past three years will be taken as examples. This paper will adopt the discourse analysis theory to summarize the problems of redundancy, Chinglish, misuse of translation strategies and mismanagement of intercultural conflict in relevant bilingual advertisements. The paper then suggests a series of ways for improvement in order to improve the quality of China English texts as well as promote intercultural communication.
New Stegosaurs from the Middle Jurassic Lower Member of the Shaximiao Formation of Chongqing, China

ABSTRACT Stegosaurs are a major clade of ornithischian dinosaurs, yet because of their fragmentary fossil record, their interrelationships and early evolution are poorly understood. Here, we describe a new stegosaur, Bashanosaurus primitivus, gen. et sp. nov., and some other indeterminate stegosaur materials. We provide new U-Pb detrital zircon ages for horizons bounding the holotypic quarry in the Lower Member of the Shaximiao Formation, Yunyang, Chongqing Municipality, China, which indicate a Middle Jurassic (Bajocian) age. Bashanosaurus represents the earliest record of stegosaurs in Asia and one of the earliest records of this clade in the world. The dorsal vertebrae, scapula, coracoid, femur, and plates of Bashanosaurus primitivus possess several unique characters among Stegosauria, including the elevation of the parapophyses of dorsal vertebrae on stalks at the base of the transverse processes, a flared distal end of the scapula, and a small acromial process. Among armored dinosaurs (thyreophorans), these features are reminiscent of the basally branching taxon Scelidosaurus, indicating that Bashanosaurus possesses a unique mosaic of plesiomorphic thyreophoran and derived stegosaur features. Phylogenetic analysis shows that Bashanosaurus primitivus is the earliest-diverging stegosaur, along with Chungkingosaurus, from the Upper Member of the Shaximiao Formation, consistent with the early age of the taxon.
Economic Vulnerability among Girls at Risk for Adolescent Pregnancy: Qualitative Findings among a Clinic Sample of Girls Residing in the U.S.–Mexico Border Region

Background: In the U.S., research to identify the risk factors explaining high rates of adolescent pregnancy disproportionately affecting racial/ethnic minorities, including Latinas, have largely focused on social and cultural factors that influence girls’ pregnancy intentions and decisions regarding the use of contraception, as well as girls’ sexual and reproductive decision-making control in relationships. However, economic factors may play a role in increasing girls’ risk for adolescent pregnancy as well. Disproportionately high rates of adolescent pregnancy occur in areas of concentrated poverty, with higher rates among ethnic minorities. This qualitative study used a descriptive, exploratory design with a content analysis approach (1) to describe economic vulnerability in girls’ lives and (2) to identify potential ways in which economic vulnerability may influence risk factors for adolescent pregnancy among adolescent females at high risk for pregnancy recruited from a health clinic by the U.S.–Mexico border in California. Methods: Qualitative in-depth interviews were conducted among 21 girls reporting risk factors for pregnancy (including a previous pregnancy, experiences of dating violence, or having ever been diagnosed with an STI) and who were seeking sexual/reproductive health services at a clinic near the U.S.–Mexico border in California. Participants were asked about their family life, economic stressors, characteristics of intimate partner relationships, and future education/career aspirations. Interviews were analyzed using content analysis to identify common themes related to economic vulnerability and risk for pregnancy. Results: Female participants were 17 years of age on average, most (72%) were Latina, and over half (60%) were in a relationship. Participants reported a high level of economic vulnerability at home, which they felt compromised their welfare, negatively affected expectations for future educational goals, and promoted financial dependence for basic needs (e.g., food) on male partners. The latter often compromised girls’ decision-making control with relationship partners over contraceptive use and pregnancy timing. Conclusions: Study findings suggest that economic vulnerability: (a) supports economic reliance on male partners, with implications for male partner control over pregnancy decisions and (b) hinders girls’ expectations for future educational opportunities, which may reduce girls’ prioritization to delay pregnancy.