Miracle-dz/UniFAR-FTUs huggingface dataset:
Hemi-Ultrathin Descemet Stripping Automated Endothelial Keratoplasty (Hemi-UT-DSAEK) Using Pediatric Donor Corneas: A Case Series

Objective: We sought to evaluate the clinical outcomes of hemi-UT-DSAEK grafts from the pediatric donor corneas of patients affected by Fuchs Endothelial Corneal Dystrophy (FECD). Methods: A prospective, interventional case series was conducted at the Ophthalmology Department of Venice Civil Hospital and the Veneto Eye Bank Foundation (Venice, Italy). Six eyes of six patients affected by FECD received large-diameter, semicircular hemi-UT-DSAEK grafts obtained from three pediatric donor corneas using the standard pull-through method. Endothelial cell density (ECD), central corneal thickness (CCT), best-corrected visual acuity (BCVA) and intraoperative and postoperative complications were recorded at different time intervals up to 12 months. Results: The average donor age was 64.6 ± 8.6 years, and the pre-operative ECD was 3266 ± 225 cells/mm2. At 12 months postoperatively, the average ECD was 1376 ± 509 cells/mm2 with a mean decrease of 56.8 ± 19.1% from the preoperative donor count. At 12 months, four out of six eyes had significantly improved and reached a BCVA of ≥20/25 (Snellen equivalent). The mean CCT significantly decreased from 788 ± 138 μm before surgery to 576 ± 30 μm at 12 months postoperatively (p < 0.01). Conclusions: Hemi-UT-DSAEK grafts using pediatric donor corneas are surgically feasible and can provide similar clinical outcomes compared to conventional UT-DSAEK. Transplanting pediatric donor tissues with high ECD into two patients could potentially increase the donor tissue pool to treat endothelial disease.
Innovative Design and Simulation of a Jumping Bipedal Robot with Leg-Wheel Transformation

The bipedal wheeled robot is expected to cope with complex and dynamically changing environments. This article introduces a bipedal-wheeled robot, Lool, which can freely switch between wheel mode, creeping mode, and jumping mode for movement. It has the advantages of small size, simple control and strong mobility, and can achieve smooth motion in complex terrains with only four motors. This article provides a detailed introduction to the mechanical structure design details of Lool, and conducts a detailed analysis of kinematics, giving specific control strategies for three motion modes. Through simulation, we validate the feasibility of our model and algorithm design, and demonstrate the robot’s good mobility and obstacle-surmounting ability.
Constructing an aggregate financial stability index for Botswana

This paper evaluates the likely benefits of adopting an aggregate financial stability index (AFSI) as an additional mechanism for monitoring the financial system in Botswana. Since the turn of the new century that brought a sequence of financial episodes, financial stability remains a topical issue among researchers and policymakers. To guard against financial instability, authorities continually look for mechanisms to effectively detect stress in the financial system. This paper builds on recent literature to develop an AFSI for Botswana constructed from sub-indices that reflect financial development, financial vulnerability, financial soundness, and external environment developments. To determine the existence, or absence, of effects from key macroeconomic variables on the AFSI, the autoregressive distributed lag (ARDL) model is used. The study found that the synthetic AFSI constructed is robust and able to track the impact of different macroeconomic events on the stability of the financial sector in Botswana. As such, gains can be expected from the use of an AFSI. In this regard, policy makers will be able to unambiguously interpret the prevailing level of financial stress and respond accordingly.
A 5 kW Hull-Compatible Inductive Charging System With 360° Folded Spatial Unipolar Coupler for Autonomous Underwater Vehicles (AUVs)

Inductive power transfer (IPT) for autonomous underwater vehicles (AUVs) presents many advantages compared to conductive solutions that require the vessel to be recovered from water in each charging cycle. This article proposes a novel 360° folded spatial unipolar coil structure adapting to a cylinder AUV body shape, aiming at low leakage magnetic field and good rotational misalignment tolerance. The finite element analysis (FEA)-based coupler design procedure is presented, and a 5 kW WPT system is implemented with an LCC-S compensation and a strong coupling coefficient of 0.735. The implemented prototype is tested in air, fresh water, and saltwater. The system shows good rotational misalignment and retains 82.9% of well-aligned power along 360° rotation. A peak power of 5.18 kW is achieved with 96.8% dc-dc efficiency in saltwater, and the performance in freshwater and air presents an efficiency of 96.8% and 96.9%, respectively, which shows a slight impact of the medium in a strongly coupled underwater IPT system. This article is accompanied by a multimedia video material demonstrating the structure and working principle of the proposed coupler.
The Wisdom of Crowds: Mutual Fund Investors' Aggregate Asset Allocation Decisions

We find that the aggregate asset allocation decisions of US mutual fund investors depend on economic conditions. Both anticipated economic downturns and periods of turmoil lead investors to direct flow away from risky equity funds and towards lower-risk money market funds. These patterns are markedly stronger for investors in low cost and low turnover funds relative to investors in high cost and high turnover funds, consistent with sophisticated investors being more sensitive to changing conditions. Benchmarked against a buy-and-hold strategy, these asset allocation strategies reduce risk without degrading the risk-return trade-off. Our evidence suggests that individual investors, often dismissed as noise traders, collectively react to economic signals in a sensible manner when determining asset allocations.
Dynamique comparée des populations de bouquetin des Alpes (Capra ibex ibex) et implication pour le suivi de ces populations

Nous avons etudie la dynamique de neuf populations de bouquetin des Alpes (Capra ibex ibex) dans cinq espaces proteges. Nous avons trouve un fort effet de l'âge sur les parametres demographqies avec en particulier une diminution de la survie apres 10-12 ans. Nous avons aussi montre une forte variabilite de la reproduction des vieilles femellles entre les populations. Contrairement a ce qui etait attendu pour une espece tres dimorphique, la survie des individus des deux sexes etait similaire, sauf pour les plus âges. La severite hivernale a un effet negatif sur la survie des vieux individus mais pas sur la reproduction et sur la survie des plus jeunes. Nous concluons que les bouquetins adoptent une strategie d'histoire de vie tres conservatrice par rapport aux autres ongules etudies jusque-la. D'un point de vue applique, nous avons aussi montre que sous certaines conditions, les comptages sont un outil satisfaisant pour suivre les tendances des populations de bouquetin
Understanding the Role of Sport Values on Social Capital and Word-of-Mouth on the Internet: A Case Study of Esports Games

Background Due to the social nature of esports (i.e., organized video game competitions), recognizing common values and norms can be leveraged as a positive driver in online gaming communities. Different game categories such as sports simulation (i.e., esports based on real-life sport events) are driving their expansion through social interactions that foster new relationships among players, known as social capital (i.e., value created from social connections, relationships, and networks within the gaming community). Despite recent studies showing the social role of esports (e.g., on satisfaction, loyalty, or well-being), little empirically derived insight exists regarding its sport values, social capital formation and positive word-of-mouth in different gamer communities on the Internet. Aim This study aims to achieve two objectives: (a) to examine how sports values (excellence, friendship and respect) influence the in-game social capital formation (bridging and bonding) and word-of-mouth intention by the esports players; and (b) to determine whether differences occur according to sports simulation and non-simulation games. Method Data were collected among esports players (n = 509), and the results were analyzed using structural equation modeling to test hypothesized relationships between the constructs and multigroup analysis to verify if the path coefficients differ among both game groups. Results Friendship value was the strongest predictor of bonding and bridging capital formation in both groups. The excellence value showed a positive effect on strong social ties created towards non-simulation games, while playing well or reaching high in-game performance did not contribute to creating bonding capital in sports simulation games. Both bonding and bridging capital were strong predictors of behavioral intentions. Conclusion Social implications focus on cultivating the sportive values and enhancing social ties on player community as a way to share good experiences or to talk positively about the game. Esports industry should consider the well-established and mediating construct of social capital, strengthening in-game bonding, and bridging relations as a broader theoretical basis.
Phytostimulatory Potential of Turan Biostimulant on the Growth and Yield of Brassica rapa subsp. chinensis (Pechay)

The growth and yield of pechay affected by Turan Biostimulant under field conditions were studied in Oogong, Sta. Cruz, Laguna Philippines to evaluate its effects and determine its best level for the optimum growth and yield of pechay. Turan is a patented high-analysis formulation with plant nutrients complexed by bioactive polyphenols that enhances nutrient availability to plants and provides a biostimulant effect to improve plant vitality and activate natural bio-defenses to protect the plant from stresses. There is a need for a plant food supplement that can promote quick nutrient absorption in the organic pechay production process, thus a randomized complete block design with four replications experiment was conducted. Parameters such as total fresh yield, marketable yield, non-marketable yield, plant height, number of leaves, leaf width, and root length/biomass were gathered from a sample of 40 plants per treatment (10/rep) and analyzed using statistical methods. The study showed that the test product was able to slightly enhance pechay production in terms of total fresh yield, plant height, leaf length, leaf width, root length, and root biomass with an estimated increase of more than 1.18%, 1.06%, 1.04%, 1.03%, 1.13%, and 1.12%, respectively, compared to inorganic fertilizer application alone. In general, pechay is very responsive to granular fertilization and the application of Turan biostimulant. The findings also showed that the addition of a biostimulant would further enhance the amount and quality of harvested pechay. One and a half doses of Turan biostimulant, or even more, is strongly recommended in terms of its viability in pechay cultivation to maximize profits.
A Junction Temperature and Package Aging Decoupling Evaluating Method for SiC MOSFETs Based on the Turn-on Drain-Source Current Overshoot

Junction temperature and package aging levels are key factors related to the reliability of SiC metal oxide semiconductor field effect transistors (mosfets). Many methods have been proposed to evaluate them for device health management. However, indicators in existing evaluating methods are usually affected by both junction temperature and package aging levels. Thus, these methods can hardly be used in real industrial applications because both two key factors are unknown. To solve this problem, a decoupling evaluating method for junction temperature and package aging levels of SiC mosfets is proposed in this article. The turn-on drain-source current overshoot is used as the indicator. First, it is discovered that there is a turning temperature point which can divide the indicator curve into two regions. Only in one region, it is sensitive to the junction temperature, but in all regions, it increases obviously with the package aging levels. Second, an evaluating strategy is proposed based on the discovered characteristic of the indicator. Aging levels can be evaluated first in a low temperature case, and the junction temperature can be obtained subsequently. Thus, the two key factors can be evaluated individually which is hard to achieve with existing methods. Finally, the effectiveness of the proposed method is verified by experiments.
Composición química y actividad antioxidante in-vitro de extractos de Adelia ricinella L . Chemical composition and in-vitro antioxidant activity of extracts of Adelia ricinella L

Adelia ricinella L. is a plant used as analgesic, antipyretic and emenagogue. In this research, three extracts from the aerial parts of the plant were prepared by Soxhlet extraction, using 95 % ethanol, 50 % and water as solvents. The main secondary metabolites were determined from qualitative and quantitative points of view. Antioxidant activity was measured using in-vitro radical scavenging methods facing ABTS and DPPH radicals. The qualitative analysis shows alkaloids, coumarins, reducing sugars, phenols, carbohydrates and flavonoids, quantifying a higher content of the last four metabolites in the ethanol 50 % extract. Similarly, the 50 % ethanol extract was the most active, determining an average inhibitory concentration (IC50) of 0,29 ± 0,01 mg/mL against ABTS and 0,53 ± 0,02 mg/mL when faced to DPPH. These evidences show that extract prepared from A. ricinella could be useful for the treatment of diseases related by oxidative stress. Clara Azalea Berenguer-Rivas, Mariuska Mas-Ortiz, Pedro L. Batista-Corbal, Jainer Costa-Acosta, Julio César Escalona-Arranz 192 Rev. Cubana Quím. , vol. 30, no. 2 mayo-agosto, 2018. e-ISSN 2224-5421
Simultaneous Control of Transmission Efficiency and Power in WPT Systems Considering Mutual Inductance Variation

In recent years, wireless power transfer (WPT) using magnetic resonant coupling has attracted much attention due to its high convenience. Many methods have been proposed to control WPT systems, such as DC-DC converters, inverters, and the positional relationship between transmitting and receiving coils. However, previous research has assumed that the mutual inductance, which cannot be measured during power transmission, is known. Therefore, this study proposes a control system that considers the variation of mutual inductance during power transmission by estimating the mutual inductance. First, the WPT system is modeled. Next, the mutual inductance estimation is explained and the control system is designed. Finally, the effectiveness of the control is demonstrated through simulations in MATLAB.
Stability Analysis and Optimal Control Design for Dual-Loop Voltage-Controlled Grid-Connected Inverters

This paper analyzes the stability of digitally dual-loop voltage-controlled inverters with consideration of grid impedance. It is revealed that both the digital delay and controller affect the system stability through adjusting the phase at the resonant frequency of the LCL filter. Then an optimal control for inner current loop is proposed to deal with different switching frequencies. Through tunning the feedback gain of inner current loop, the control scheme can cope with different switching frequencies or delays to keep system stable. Then the stable regions presented as the value range of current feedback gain are derived. Simulation and experiment validate the stability analysis and effectiveness of the proposed control.
COULD PERSONALITY, CHARACTERISTICS OF VIOLATIONS, AND PERCEPTIONS OF THE ORGANIZATIONAL ENVIRONMENT BE A FACTOR DRIVING THE WHISTLEBLOWING INTENTION?

The objective of this paper is to examine the effect of personality, perceptions of the organizational environment, and characteristics of violations on the whistleblowing intention in educational institutions. This study is expected to contribute to the management of higher education to protect their organization from fraud. Personality variable has three proxies, namely perceptions of reporting costs, locus of control, and organizational commitment. The organizational environment perception has 3 proxies, namely the perception of the internal control system, organizational climate and organizational support, while the characteristics of fraud are proxied by the status of the violation and the seriousness of the violation. The participants of this study were lecturers in universities in Semarang. The data were collected from the surveys using random sampling method. Questionnaires on whistleblowing were distributed to lecturers and we get 100 participants. The data was processed use a multiple linear regression with SPSS software. The result of this study showed that the organizational climate and the seriousness of the violation positively affected the whistleblowing intention. Meanwhile, the organizational commitment, perception of the cost of violations, internal locus of control, organizational support, the internal control system and the status of the violation did not significantly affect the whistleblowing intention.
In vivo and In vitro Bioequivalence Testing

For approval of generic drug products, the FDA requires that evidence of average bioequivalence in drug absorption be provided through the conduct of bioequivalence studies. As indicated in 21CFR320.24, bioequivalence may be established by in vivo (e.g., pharmacokinetic, pharmacodynamic, or clinical) and in vitro studies or with suitable justification by in vitro studies alone. In this presentation, an overview of statistical considerations including study design, criteria, and statistical methods for assessment of bioequivalence will be provided. For in vivo bioequivalence testing, in addition to average bioequivalence, the concept of population bioequivalence and individual bioequivalence for addressing drug interchangeability will also be discussed. For in vitro bioequivalence testing, an overview regarding some in vitro tests such as dose or spray content uniformity through container’s life, droplet and drug particle size distribution, spray pattern, plume geometry, priming and repriming, and tail off profile that are commonly employed for local action drug products such as nasal aerosols and nasal sprays products will be provided. Recent development and future research topics will also be discussed.
The role of microRNAs in muscle wasting and recovery during critical illness: a systematic review

Critical illness associated with intensive care unit (ICU) admission often results in persistent skeletal muscle wasting and may lead to frailty in older and patients with multi‐morbidity. Early recognition of patients at high‐risk of long‐term complications could provide opportunities to minimize the impact of critical illness and improve health and quality of life. MicroRNAs (miRs) are short, non‐coding RNAs that regulate approximately two‐thirds of the human genome and are involved in most biological processes. Multiple studies have demonstrated their role in muscle development and disease and their potential as biomarkers of muscle wasting.
Towards Granting of Legal Personality to Autonomous Robots in the UAE

The Dubai Digital Government launched its recent guidelines, which call for artificial intelligence systems to be subject to legal accountability. This study discusses the extent to which autonomous robots can be granted legal personality in UAE law and the consistency of this approach with the provisions of Islamic jurisprudence. This research paper answered two main questions: First, the extent to which these guidelines are considered the beginning of work on granting legal personality to AI systems in the UAE. Second, what form of legal personality can be given to autonomous robots in UAE law to be consistent with the provisions of Islamic jurisprudence as a primary source of legislation in the country? The research concluded the impossibility of considering autonomous robots as a "thing" and classifying them within the concept of "persons. " It also concluded that it is possible to give them legal personality according to two legislative solutions: granting them partial or incomplete performance eligibility like minors.
Idiosyncratic DILI and RUCAM under One Hat: The Global View

Drugs are prescribed worldwide to treat diseases but with the risk of idiosyncratic drug-induced liver injury (iDILI). The most important difficulty is how best to establish causality. Based on strong evidence and principles of artificial intelligence (AI) to solve complex processes through quantitative algorithms using scored elements, progress was achieved with the Roussel Uclaf Causality Assessment Method (RUCAM) in its original and updated versions, often viewed now as the gold standard. As a highly appreciated diagnostic algorithm, the RUCAM is in global use with around 100,000 iDILI cases published worldwide using RUCAM to assess causality, largely outperforming any other specific causality assessment tool in terms of case numbers. Consequently, the RUCAM helps to establish a list of top-ranking drugs worldwide implicated in iDILI and to describe clinical and mechanistic features of iDILI caused by various drugs. In addition, the RUCAM was recently applied in iDILI cases of patients treated for coronavirus disease 2019 (COVID-19) infections or cancer patients treated with immune checkpoint inhibitors (ICIs), as well as in the search for new treatment options with conventional drugs in iDILI. Analyses of RUCAM-based iDILI cases are helpful to support pathogenetic steps like immune reactions, genetic predisposition as evidenced by human leucocyte antigens (HLA) genotypes for selected drugs, and the role of the gut microbiome. To achieve consistency in data collection, analysis, and specific clinical and pathogenetic presentation, researchers, regulatory agencies, and pharmaceutical firms should place iDILI and the updated RUCAM as the causality tool under one and the same hat in review articles and clinical guidelines for the diagnosis and treatment of iDILI.
Cardiovascular and Pulmonary Entry-Level Physical Therapist Competencies: Update by Academy of Cardiovascular & Pulmonary Physical Therapy Task Force

Purpose: Competency-based education and creation of profession-based entrustable professional activities are current trends in physical therapist (PT) education. The purpose of this project is to determine the current entry-level PT competencies for cardiovascular & pulmonary (CVP) physical therapy. Methods: The Academy of Cardiovascular & Pulmonary Physical Therapy Competency Task Force was established to update and expand previous competencies. A mixed method approach of Subject Matter Expert (SME) consensus (modified Delphi process) and a broader survey process was used to develop these entry-level competencies. With SME guidance, a modified version of the levels of competence, None-to-Proficient, was adopted based on previous competency work by the American Council of Academic Physical Therapy. Results: Twenty-nine SME members engaged in the consensus process, and 268, 194, 305, and 222 respondents completed the 4 surveys, respectively. Six hundred fifty-one competency items were rated across most Commission on the Accreditation of Physical Therapy Education Standard 7 Curriculum areas, following the patient–client management model. Conclusions: These competencies establish specific expected levels of knowledge, skills, and behaviors essential for entry-level CVP PT practice. Adopting these competencies will help lay the groundwork for future competency-based PT education and aid in the development of the physical therapy profession's core entrustable professional activities.