Miracle-dz/UniFAR-FTUs huggingface dataset:
Current Sites of Infections and Types of Microorganisms in Patient with Febrile Neutropenia in Hematological Wards – Single Center Study

BACKGROUND: Febrile neutropenia occurs in more than 80% of patients with hematological malignances specially after chemotherapy cycles and an infectious source is identified in approximately 20–30%. Various bacterial, viral, and fungal pathogen contribute to the development of neutropenic fever and without prompt antibiotic therapy mortality rate can be as high as 70%. AIM: The objective of the study was to document the current sites of infection in patients with febrile neutropenia in hematological ward in Baghdad Teaching Hospital, the microorganisms and antibiotic susceptibly in culture positive cases and mortality rate in 1 week and 4 weeks after episode of fever. PATIENTS AND METHODS: One hundred cases of febrile neutropenia were evaluated in Hematological Ward of Baghdad Teaching Hospital from January 2019 to January 2020. Detailed history, physical examination, and laboratory investigations were conducted and statistical analysis of the results was done. RESULTS: One hundred cases of febrile neutropenia, mean age of presentation was 41.56 ± 10.5 years. Acute myeloid leukemia (36%) and acute lymphocytic leukemia (26%) were the most common underlying hematological disorder, followed by Aplastic Anemia, Non-Hodgkin Lymphoma, and Hodgkin Lymphoma. Temperature ranged from 38°C to 39°C with mean temperature of 38.4°C and most of the patient presented with short duration of fever, 57% had absolute neutrophil count below 150 cells/μL with mean duration of neutropenia was 14.01 days. Respiratory tract was the most common site of infection (52%) followed by urinary tract (18%) and in 16% had no obvious focus of infection. Thirty percent of cases were culture Gram-positive and Gram-negative microorganism which were more common 62.9% which were generally sensitive to Aminoglycosides while Gram-positive microorganism constituted 29.6% of isolated bacteria and were generally sensitive to vancomycin. No mortality documented 1 and 4 weeks after fever. CONCLUSION: We concluded that the most frequent sites of infection in patient with febrile neutropenia were respiratory tract followed by urinary tract infection, while 16% had undetermined source of infection. Thirty percent of patients had a positive blood culture with Escherichia coli being the most common infecting microorganism, Gram-negative microorganisms were more common than Gram-positive microorganism and fungal infection constituted about 6% of growth. Significant association was found between the fever and longer duration of neutropenia and the greater severity of neutropenia was observed. No mortality related to febrile neutropenia was documented.
Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP) in an Indian Man

Annals of Indian Academy of Neurology ¦ Volume 25 ¦ Issue 4 ¦ July-August 2022 720 Dear Editor, Adult‐onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare cause of adult‐onset leukodystrophy. It is most often inherited in an autosomal dominant mode and was previously known as hereditary leukoencephalopathy with axonal spheroids. Typically, patients in their middle age present with progressive cognitive decline and behavioral changes with pyramidal or extra‐pyramidal signs. A high index of suspicion is required to make an early diagnosis. We describe a middle‐aged Indian male with ALSP. A 53‐year‐old army veteran with a history of systemic hypertension presented with long‐standing and progressive cognitive decline. He had developed progressive memory impairment, wandering, aggressive behavior, difficulty walking on uneven ground, burning sensation in the feet, bowel–bladder abnormalities, and new onset gustatory facial hyperhidrosis for the past five years. As he was unable to carry out his duties, he resigned and pursued another career. However, he was unable to cope with the demands of his new job and had to resign again. He had six healthy brothers and there were no similar family complaints.
Periodontitis-Related Knowledge and Its Relationship with Oral Health Behavior among Adult Patients Seeking Professional Periodontal Care

Background: Periodontitis is a chronic inflammatory disease that not only damages the stomatognathic system, but may also adversely influence other systems and organs. Patients with low oral health literacy levels are more prone to gingivitis/periodontitis and have a more severe disease course. Methods: A written questionnaire was carried out to assess the knowledge of patients of the Outpatient Clinic of Department of Periodontal and Oral Mucosa Diseases, Medical University of Bialystok, Poland. The questions concerned knowledge regarding the causes of periodontal disease, its risk factors, and the connection between periodontal disease and general health status. To analyze the population, patients were divided according to gender, age and if they were first-time or regular outpatients. Results: Written questionnaires were completed by a total of 302 patients. In the studied population, we noted knowledge deficits, particularly related to weaker periodontal disease risk factors (stress, diabetes, osteoporosis, obesity) and the genetic factor, which is the determinant of periodontitis. The patients’ awareness of the role of plaque bacteria and the effect of smoking on the periodontium was at a relatively high level. The respondents were also aware of the impact of periodontal disease on general health as well as the role of oral hygiene in preventing the disease. At the same time, few of them (26%) used interdental brushes or an irrigator (8%). Conclusions: We demonstrated that patients have an insufficient level of knowledge related to risk factors as well as the prevention of periodontal disease. Awareness of the extent of oral health literacy among patients will help to identify key issues connected with health education interventions
Comparison between Conventional PMMA and 3D Printed Resins for Denture Bases: A Narrative Review

The aim of the current paper is to review the available literature reporting on comparative studies of heat-cured resins and three-dimensionally printed biomaterials for denture bases in terms of their composition, properties, fabrication techniques and clinical performance. The methodology included applying a search strategy, defining inclusion and exclusion criteria, selecting studies to summarize the results. Searches of PubMed, Scopus, and Embase databases were performed independently by three reviewers to gather literature published between 2018 and 2021. A total of 135 titles were obtained from the electronic databases, and the application of exclusion criteria resulted in the identification of 42 articles pertaining to conventional and 3D printed technology for removable dentures. The main disadvantages of the heat-cured resins for removable dentures are that they require lots of special equipment, skilled personnel and time. Emerging technologies, such as 3D printed dentures, have the potential to alleviate these problems allowing for faster patient rehabilitation. With the development of digital dentistry, it is becoming increasingly necessary to use 3D printed resin materials for the manufacturing of removable dentures. However, further research is required on the existing and developing materials to allow for advancement and increase its application in removable prosthodontics.
The Influence of the Modulation Index on Frequency-Modulated Steady-State Visual Evoked Potentials

Based on increased user experience during stimulation, frequency-modulated steady-state visual evoked potentials (FM-SSVEPs) have been suggested as an improved stimulation method for brain-computer interfaces. Adapting such a novel stimulation paradigm requires in-depth analyses of all different stimulation parameters and their influence on brain responses as well as the user experience during the stimulation. In the current manuscript, we assess the influence of different values for the modulation index, which determine the spectral distribution in the stimulation signal on FM-SSVEPs. We visually stimulated 14 participants at different target frequencies with four different values for the modulation index. Our results reveal that changing the modulation index in a way that elevates the stimulation power in the targeted sideband leads to increased FM-SSVEP responses. There is, however, a tradeoff with user experience as increased modulation indices also lead to increased perceived flicker intensity as well as decreased stimulation comfort in our participants. Our results can guide the choice of parameters in future FM-SSVEP implementations.
Educational and skills mismatches: unravelling their effects on wages across Europe

ABSTRACT This paper is among the first to investigate the impact of over-education and over-skilling on workers’ wages using a unique pan-European database covering twenty-eight countries for the year 2014, namely the CEDEFOP’s European Skills and Jobs (ESJ) survey. Overall, the results suggest the existence of a wage penalty associated with over-education. When the educational and the skills mismatches are interacted with each other in order to distinguish apparent over-education from genuine over-education, the results highlight that the workers with the highest wage penalty are those who are both over-educated and over-skilled.
Avaliação de Soluções mHealth no contexto da violência contra as mulheres

Resumo — O presente estudo buscou avaliar soluções mHealth utilizadas no contexto da violência contra as mulheres. Estudo de avaliação que considerou o instrumento Mobile App Rating Scale. Mediante resultados apresentados pode-se concluir que os aplicativos incluídos no estudo obtiveram avaliação satisfatória pelo instrumento MARS. Os achados desta pesquisa evidenciaram a lacuna de incorporação de diretrizes clínicas, podendo-se abordar tal questão em futuros projetos, visando o atendimento de vítimas de violência em serviços de saúde.
The value of ADC calculations in the assessment of the early response of hepatocellular carcinoma (HCC) to trans arterial catheter chemoembolization (TACE).

Transcatheter arterial chemoembolization (TACE) is a well-accepted method for Treatment of unresectable hepatocellular carcinoma (HCC). Determining the success of treatment by imaging studies would help to guide subsequent therapeutic planning. Diffusion-weighted imaging (DWI) with calculation of corresponding apparent diffusion coefficient (ADC) maps can give us an impression about the extent of the tumor necrosis after TACE. Also rapid image acquisition and dispensing of contrast are considered superior pros. Objective: To investigate changes in apparent diffusion coefficient (ADC) levels pre and post TACE to monitor early therapeutic response of hepatocellular carcinoma (HCC) to transcatheter arterial chemoembolization (TACE). Patients and methods: 20 patients with 22 lesions included in the study, underwent TACE for HCC lesions, All patients had MR-DWI pre TACE and 1 month after TACE with calculation of ADC values and comparing the percentage of change in ADC level pre and post TACE in 1 month after TACE with the results of contrast enhanced Dynamic MRI 3 or 6 month after TACE based on MRECIST criteria. Results: Of about 20 patients, 22 lesions was treated, ADC levels 1 month post-operative showed 75% sensitivity, 80% specificity and about 77.27% accuracy. It was found that the specificity of degree of ADC change is maximized by gaining at least 22% increase in ADC value, and the sensitivity is maximized by gaining less than 15% increase in ADC. At these points sensitivity increased to 91.67% and specificity up to 90%. Conclusion: the calculation of percentage of change in ADC levels 1 month after TACE with addition of specific Cut off values can improve the accuracy of assessment of early response to TACE and create proper planning for achievement of treatment goals. Although larger, more definitive and quantitative studies with clinical end points are needed.
Exploiting Higher Order Multi-dimensional Relationships with Self-attention for Author Name Disambiguation

Name ambiguity is a prevalent problem in scholarly publications due to the unprecedented growth of digital libraries and number of researchers. An author is identified by their name in the absence of a unique identifier. The documents of an author are mistakenly assigned due to underlying ambiguity, which may lead to an improper assessment of the author. Various efforts have been made in the literature to solve the name disambiguation problem with supervised and unsupervised approaches. The unsupervised approaches for author name disambiguation are preferred due to the availability of a large amount of unlabeled data. Bibliographic data contain heterogeneous features, thus recently, representation learning-based techniques have been used in literature to embed heterogeneous features in common space. Documents of a scholar are connected by multiple relations. Recently, research has shifted from a single homogeneous relation to multi-dimensional (heterogeneous) relations for the latent representation of document. Connections in graphs are sparse, and higher order links between documents give an additional clue. Therefore, we have used multiple neighborhoods in different relation types in heterogeneous graph for representation of documents. However, different order neighborhood in each relation type has different importance which we have empirically validated also. Therefore, to properly utilize the different neighborhoods in relation type and importance of each relation type in the heterogeneous graph, we propose attention-based multi-dimensional multi-hop neighborhood-based graph convolution network for embedding that uses the two levels of an attention, namely, (i) relation level and (ii) neighborhood level, in each relation. A significant improvement over existing state-of-the-art methods in terms of various evaluation matrices has been obtained by the proposed approach.
Hot-Air Drying Characteristics of Sea Cucumber (Apostichopus japonicus) and Its Rehydration Properties

Drying is one of the most common methods for processing and preserving sea cucumber. Based on the research of pretreatment and drying process, this paper develops a dried sea cucumber product that can be quickly rehydrated in only 8 hours. By setting the pretreatment at heated water temperature of 80°C and the drying temperature from 30°C to 60°C, the fitting model is found by comparing empirical formulas and artificial neural networks. The ANN-based model was demonstrated to fit the experimental data for the adequate drying of sea cucumber. Following the increased drying temperature, the drying time was decreased and the rehydration ratio was increased. The sensory evaluation and texture properties dried at 40°C and 50°C were much better than those dried at 30°C and 60°C. Microstructure of rehydrated dried sample showed that increasing the temperature leads to the increase of fiber pore space, and the rehydration rate increases. The results of drying time and the rehydration properties of sea cucumber showed that 50°C is the best drying condition for hot-air drying of sea cucumber. The developed rapid rehydration dried sea cucumber can effectively simplify the rehydration time and steps of the dried sea cucumber and improve the quality of the sea cucumber, and it is considered to be a good technology for drying the sea cucumber and making a fast rehydration dried sea cucumber that can be further used for value-added product.
Preparation and optimization of berberine phospholipid complexes using QbD approach and in vivo evaluation for anti-inflammatory, analgesic and antipyretic activity

Berberine (BER) is a benzylisoquinoline alkaloid found in many plants. It has high water solubilitybut its bioavailability is low in oral administration due to the first-pass effect in the liver and intestine. Phytosomesare are prepared by complexing herbal active ingredients and phospholipids (PLs). The aim of this study is to prepare BERphospholipidcomplexes (BPCs) using the reverse phase evaporation method. In the preparation of the formulations, the effects of BER:PL ratio (w/w), reaction temperature (°C) and reaction time (h) on the specifications of the complexes such as particle size (PS), zeta potential (ZP) and encapsulation efficiency (EE%) were investigated. The distribution of PS of obtained complexes was ranging between 339 -1259 nm and their ZP were within -4,27-5,15 mV. The drug EE% was relatively high. Quality by Design (QbD) methods have been used in the formulation design and selection of the optimum formulation. BPCs anti-inflammatory, analgesic and antipyretic activities are evaluated by using in vivo methods.Carrageenan-, Prostaglandin E2 (PGE2)and serotonin-induced hind paw edema, acetic acid-induced increase in capillary permeability and subcutaneous air-pouch models for the anti-inflammatory activity, inhibition of pbenzoquinone-induced abdominal constriction and hot plate test for the analgesic activity, Freund’s complete adjuvantinduced pyrexia model for the antipyretic activity were used in mice and rats. Results showed that BPCs showed potent anti-inflammatory, analgesic and antipyretic activities at the dose of 209 mg/kg.
Reliable Binarized Neural Networks on Unreliable Beyond Von-Neumann Architecture

Specialized hardware accelerators beyond von-Neumann, that offer processing capability in where the data resides without moving it, become inevitable in data-centric computing. Emerging non-volatile memories, like Ferroelectric Field-Effect Transistor (FeFET), are able to build compact Logic-in-Memory (LiM). In this work, we investigate the probability of error (Perror) in FeFET-based XNOR LiM, demonstrating the new trade-off between the speed and reliability. Using our reliability model, we present how Binarized Neural Networks (BNNs) can be proactively trained in the presence of XNOR-induced errors towards obtaining robust BNNs at the design time. Furthermore, leveraging the trade-off between Perror and speed, we present a run-time adaptation technique, that selectively trades-off Perror and XNOR speed for every BNN layer. Our results demonstrate that when a small loss (e.g., 1%) in inference accuracy could be accepted, our design-time and run-time techniques provide error-resilient BNNs that exhibit 75% and 50% (FashionMNIST) and 38% and 24% (CIFAR10) XNOR speedups, respectively.
Four-strands versus six-strands core sutures technique for surgical management of acute zone II flexor tendon injury

This randomized prospective comparative study was conducted on 52 patients (60 fingers) who sustained acute zone 2 flexor tendon injury in the form of complete laceration of isolated FDP tendon or combined FDP and FDS tendons. All patients were operated in the period between March 2017 and January 2020 in Minia Hand and Microsurgery Unit (MHMU) in orthopaedic surgery department. The injured fingers were repaired using either a 4-strand or a 6-strand core suture repair by simple random selection using sealed envelope method. The patients were divided into 2 groups: Group A: Patients were managed by 4-strand; double modified Kessler core suture and Group B: Patients were managed by 6-strand; triple modified Kessler core suture. Post operatively, the patients were instructed to start early controlled active motion from the first day. Then, they were assessed regularly at the 4th, 8th and 12th week of rehabilitation for: Visual analogue scale (VAS), Grip strength and Total active motion (TAM). There was no significant differences in grip strength in both groups measured in comparison with the other normal side at all examination time point but the difference between TAM is significant all through measurement time points between the 2 studied groups. so, the 6-strand repair is superior to the 4-strand repair regarding the TAM and effective PIPJ and DIPJ flexion. It was also found that 6-strand repair gives a better range of extension through different interphalangeal joints.
Recent Achievements of Egyptian Sugarcane Breeding Program

Egyptian sugarcane breeding program depends upon natural flowering and artificial flowering. Natural flowering at El-Sabahia Agriculture Research Station (31.2 N latitude), Alexandria, Egypt is used to evaluate number of sugarcane germplasm for natural flowering ability and determine their flowering dates. The natural flowering season extendes from November, 1 to the end of June. Artificial flowering conducts at Giza Agriculture Research Station (30.01 N latitude), Giza, Egypt and used to estimate the number of inductive cycles for inducing the desirable parents from the available germplasms in the program to flower and synchronize their flowering dates to make planed crosses. Fuzz produced from planed crosses is used to establish the seedling stage, which follow by other selection stages to develop improving sugarcane variety. Increasing the size of the germplasm collection, promising clones at all selection stages and registration of Giza.3 and Giza.4 verities were the recent achievements of the breeding program. In addition to, resistant to smut disease Giza.3 and Giza.4 varieties have high cane and sugar yields. Besides, Giza.3 is an early mature variety and Giza.4 is a moderate mature variety.
Multiple drivers and controls of pockmark formation across the Canterbury Margin, New Zealand

Shallow seabed depressions attributed to focused fluid seepage, known as pockmarks, have been documented in all continental margins. In this study, we demonstrate how pockmark formation can be the result of a combination of multiple factors—fluid type, overpressures, seafloor sediment type, stratigraphy and bottom currents. We integrate multibeam echosounder and seismic reflection data, sediment cores and pore water samples, with numerical models of groundwater and gas hydrates, from the Canterbury Margin (off New Zealand). More than 6800 surface pockmarks, reaching densities of 100 per km2, and an undefined number of buried pockmarks, are identified in the middle to outer shelf and lower continental slope. Fluid conduits across the shelf and slope include shallow to deep chimneys/pipes. Methane with a biogenic and/or thermogenic origin is the main fluid forming flow and escape features, although saline and freshened groundwaters may also be seeping across the slope. The main drivers of fluid flow and seepage are overpressure across the slope generated by sediment loading and thin sediment overburden above the overpressured interval in the outer shelf. Other processes (e.g. methane generation and flow, a reduction in hydrostatic pressure due to sea‐level lowering) may also account for fluid flow and seepage features, particularly across the shelf. Pockmark occurrence coincides with muddy sediments at the seafloor, whereas their planform is elongated by bottom currents.