Miracle-dz/UniFAR-FTUs huggingface dataset:
Genome-wide identification and expression of CYP71 gene family in response to low-temperature stress in banana

ABSTRACT CYP71 belongs to cytochrome P450 (CYP) monooxygenase superfamily, which is functionally diverse and participates in shikimic acid pathway and the secondary metabolism of tryptophan. We identified 58 MaCYP71s and 14 MbCYP71s from the Musa acuminata Colla and Musa balbisiana Colla, and investigated the biological function of the banana CYP71 gene family. Analysis of conserved domain motifs showed that MaCYP71 was more conservative than MbCYP71. Through cluster analysis, MaCYP71 could be divided into 11 subgroups, and MbCYP71 could be divided into 4 subgroups. The expansion of the MaCYP71s might result from the combined actions of tandem and segmental duplications 17% of the MaCYP71 were found to be potentially responsive to low temperature. Exon skipping was the main alternative splicing events of MaCYP71. According to FPKM value and qPCR analysis of MaCYP71 at low temperature, the expressions of MaCYP71A1-4, MaCYP78A6-2, MaCYP78A5-5, and MaCYP78A6-3 at 4°C and 0°C were significantly higher than those at 28°C, which reflected their possible association with response to low-temperature stress. Fifteen members of MaCYP71 family were mainly regulated by miRNA (miR398 and novel_7. 15). MaCYP71s were targeted by 26 lncRNA genes, of which 13 lncRNAs were upregulated in expression at 4°C. From the above studies, it was suggested that MaCYP71 play a vital role in response to low-temperature stress in banana.
Microclimate control to increase productivity and nutritional quality of leafy vegetables in a cost-effective manner

Food security is one of the key global challenges in this century. In Singapore, our research team has been using novel aeroponic technology to produce fresh vegetables since 1997. Aeroponic systems allow for year-round production of not only tropical, but also sub-tropical and temperate fresh vegetables, by simply cooling the roots suspended in aeroponic systems while the aerial parts grow under tropical ambient environments. It has also been used to investigate the impacts of root-zone CO2 on vegetables by enriching root-zone CO2 while their aerial portions were subjected to constant atmospheric CO2. To compensate for the lack of available land, Singapore also needs to develop a farming system that can increase productivity per unit land area by many-fold. Over the past 10 years, my research team has established a commercially viable LED integrated vertical aeroponic farming system to grow different leafy vegetables under different LED spectra, intensities, and durations in the tropical greenhouse. The results demonstrate that it is possible to increase shoot production and rate of shoot production of leafy vegetables by increasing light intensity and extending the photoperiod under effective LED lighting. Furthermore, temperate vegetable crops such as lettuce were able to acclimate to high light intensity under supplementary LED lights to natural sunlight in the greenhouse. Supplementary LED lightings promote both leaf initiation and expansion with increased photo synthetic pigments, higher Cyt b6f and Rubisco protein contents on a per area basis and thus improve photosynthetic capacity and enhance productivity. Plants sense and respond to changes in their immediate environments (microclimate), manipulating the root zone temperature (RZT) and water supply will impact not only their growth and development but also their nutritional quality. Our on-going research aims to investigate if the nutritional quality of leafy vegetables could be improved under suboptimal RZT and mild water deficit through deficit irrigation. If substantial energy and water savings in urban farming can be achieved without substantial yield penalty but with higher nutritional quality, the amount of water and energy saved can bring substantial benefits to society.
Acute effects of continuous exercise, interval exercise, and sedentary colouring on anxiety, mood, and physical activity enjoyment

ABSTRACT Acute bouts of cardiorespiratory exercise have been shown to improve anxiety and mood; however, there is limited research comparing interval and continuous exercise in regards to specific mood states, as well as, comparing exercise to other potential mood-altering activities, such as colouring. The purpose of this randomised cross-over experiment was to examine the immediate effects of two patterns of treadmill exercise (continuous vs. interval) and sedentary colouring on anxiety and mood, and explore differences in physical activity enjoyment. A total of 27 participants (M age = 21.4 years) completed 25 min of each condition: continuous exercise, interval exercise, and sedentary colouring during separate testing sessions. The exercise bouts included a warm-up, cool-down, and 20 min of condition-specific exercise. Results indicate that treadmill exercise led to significantly greater improvements in feelings of vigour and total mood disturbance compared to sedentary colouring with no differential effects between the two patterns of treadmill exercise. Other mood states were enhanced by all three conditions. The findings suggest that individuals seeking to enhance feelings of energy are not limited to engaging in a specific pattern of cardiorespiratory exercise. Individuals pursuing acute improvements in anxiety, anger, confusion, fatigue, and tension may have flexibility in choosing an activity that could modify those mood states by engaging in continuous exercise, interval exercise, or sedentary colouring. Future studies should compare these three conditions with a control group not tasked with an activity to gain a clearer picture of the enhanced mood states observed in the present study.
Children With Short Stature Display Reduced ACE2 Expression in Peripheral Blood Mononuclear Cells

Background The cause of short stature remains often unknown. The renin-angiotensin system contributes to growth regulation. Several groups reported that angiotensin-converting enzyme 2 (ACE2)-knockout mice weighed less than controls. Our case-control study aimed to investigate if children with short stature had reduced ACE2 expression as compared to controls, and its significance. Materials and Methods children aged between 2 and 14 years were consecutively recruited in a University Hospital pediatric tertiary care center. Cases were children with short stature defined as height SD ≤ −2 diagnosed with growth hormone deficiency (GHD) or idiopathic short stature (ISS), before any treatment. Exclusion criteria were: acute diseases, kidney disease, endocrine or autoimmune disorders, precocious puberty, genetic syndromes, SGA history. ACE and ACE2 expression were measured in peripheral blood mononuclear cells, angiotensins were measured by ELISA. Results Children with short stature displayed significantly lower ACE2 expression, being 0.40 fold induction (0.01-2.27) as compared to controls, and higher ACE/ACE2, with no differences between GHD and ISS. ACE2 expression was significantly and inversely associated with the risk of short stature, OR 0.26 (0.07-0.82), and it had a moderate accuracy to predict it, with an AUC of 0.73 (0.61-0.84). The cutoff of 0.45 fold induction of ACE2 expression was the value best predicting short stature, identifying correctly 70% of the children. Conclusions Our study confirms the association between the reduction of ACE2 expression and growth retardation. Further studies are needed to determine its diagnostic implications.
GSA-Fuzz: Optimize Seed Mutation with Gravitational Search Algorithm

Mutation-based fuzzing is currently one of the most effective techniques to discover software vulnerabilities. It relies on mutation strategies to generate interesting seeds. As a state-of-the-art mutation-based fuzzer, AFL follows a mutation strategy with high randomization, which uses randomly selected mutation operators to mutate seeds at random offsets. Its strategy may ignore some efficient mutation operators and mutation positions. Therefore, in this paper, we propose a solution named GSA-Fuzz to improve the efficiency of seed mutation strategy with the gravitational search algorithm (GSA). GSA-Fuzz uses GSA to learn the optimal selection probability distributions of operators and mutation positions and designs a position-sensitive strategy to guide seed mutation with learned distributions. Besides, GSA-Fuzz also provides a flip mode to calculate the efficiencies of the deterministic stage and indeterministic stage and implements switching between the two stages to further improve the efficiency of seed mutation. We compare GSA-Fuzz with the state-of-the-art fuzzers AFL, MOPT-AFL, and EcoFuzz on 10 open-source programs. GSA-Fuzz finds 145% more paths than AFL, 66% more paths than EcoFuzz, and 43% more paths than MOPT-AFL. In addition, GSA-Fuzz also outperforms other fuzzers in bug detection and line coverage.
Motor Influence in Developing Auditory Spatial Cognition in Hemiplegic Children with and without Visual Field Disorder

Spatial representation is a crucial skill for everyday interaction with the environment. Different factors seem to influence spatial perception, such as body movements and vision. However, it is still unknown if motor impairment affects the building of simple spatial perception. To investigate this point, we tested hemiplegic children with (HV) and without visual field (H) disorders in an auditory and visual-spatial localization and pitch discrimination task. Fifteen hemiplegic children (nine H and six HV) and twenty with typical development took part in the experiment. The tasks consisted in listening to a sound coming from a series of speakers positioned at the front or back of the subject. In one condition, subjects were asked to discriminate the pitch, while in the other, subjects had to localize the position of the sound. We also replicated the spatial task in a visual modality. Both groups of hemiplegic children performed worse in the auditory spatial localization task compared with the control, while no difference was found in the pitch discrimination task. For the visual-spatial localization task, only HV children differed from the two other groups. These results suggest that movement is important for the development of auditory spatial representation.
PENGARUH KUALITAS PELAYANAN DAN KEMUDAHAN TERHADAP LOYALITAS DENGAN KEPUASAN PELANGGAN SEBAGAI VARIABEL INTERVENING

Abstrak Tujuan penelitian adalah untuk mengetahui pengaruh kualitas pelayanan dan kemudahan terhadap loyalitas dengan kepuasan sebagai variable intervening. Populasi dalam penelitian ini seluruh pelanggan yang menggunakan Jenius Mobile berjumlah 2,8 juta hingga akhir September 2020. Dengan jumlah sampel sebanyak 100 responden. Metode analisis yang digunakan adalah analisis jalur. Berdasarkan hasil penelitian dan pembahasan yang telah dilakukan, maka dapat ditarik kesimpulan sebagai berikut: tidak ada pengaruh Service Quality yang diberikan Jenius Mobile terhadap loyalitas pelanggan, tetapi ada pengaruh terhadap kepuasan pelanggan, dan tidak ada pengaruh terhadap kepuasan pelanggan. Pengaruh Kualitas Pelayanan melalui Kepuasan terhadap Loyalitas Pelanggan. Kemudian tidak ada pengaruh Ease terhadap loyalitas pelanggan, tetapi ada pengaruh terhadap kepuasan pelanggan, dan tidak ada pengaruh melalui kepuasan terhadap loyalitas pelanggan. Kemudian ada pengaruh kepuasan terhadap loyalitas pelanggan.
Comparison of Effectiveness of Trunk PNF Versus NDT on Trunk Stability in Stroke Patients

Stroke is the commonest neurological deficit caused by an interruption of the blood flow to the brain and loss of trunk control is commonly observed in patients after stroke. Impaired trunk control has a negative impact on daily activities and quality of life(QOL) in patients after stroke. Proprioceptive Neuromuscular Facilitation (PNF) and Neurodevelopmental technique (NDT), both are effective in improving trunk control in hemiplegic patients by improving trunk muscle endurance, strength, and trunk mobility. This study is aimed to compare the effectiveness of trunk PNF and NDT to improve trunk stability in patients with stroke. The objective of the study was to compare the effectiveness of trunk proprioceptive neuromuscular facilitation and neuro-developmental therapy based on trunk protocol with conventional therapy to improve trunk stability in stroke patients 30 subjects who fulfilled the criteria were taken for the study and was categorised into 2 groups of A and B, each having 15 subjects. Group A received trunk proprioceptive neuromuscular facilitation along with conventional therapy & group B received neuro-developmental therapy based on trunk protocol along with conventional therapy respectively for 4 weeks. Before the study, all the subjects were assessed using a general assessment proforma. Both pre and post-treatment assessments were assessed by using trunk impairment scale and ROM of trunk flexion and extension. The results of statistical analysis were tabulated in terms of mean, standard deviation, variance, t-test, P-value, coefficient of variation in both groups. Paired t-test showed that there was a statistically significant improvement in both groups (P<0.05). The coefficient of variation is significant at the CV of group A (83.34) less than the CV of group B (100.16), therefore group A is more effective compared to group B. In this study, it was found that the trunk PNF technique with conventional exercises and NDT based on trunk protocol with conventional exercises was effective to improve trunk stability in acute or subacute stroke patients. But, the trunk PNF technique with conventional exercises was more effective than NDT based on the trunk protocol conventional exercises technique for improving the trunk stability in acute or sub acute stroke patients.
Modelling Uncertainties of Italian Code-Conforming Structures for the Purpose of Seismic Response Analysis

ABSTRACT This paper describes the multivariate statistical model of the structure-related modelling uncertainty, developed with reference to reinforced concrete, masonry, steel, and seismically isolated buildings, within the framework of the RINTC project. The model describes the variability of material properties as well as the uncertainty associated with the adopted response models. Specific aspects of each structural typology are also discussed, with a focus on the statistical dependence of the random variables in the model. Finally, the paper describes also the efficient sampling procedure adopted. Effect of model uncertainty on response for each typology are discussed in the corresponding papers within this special issue dedicated to the RINTC project.
Algebraic method of regional green wave coordinated control

Abstract This study proposes an algebraic method of regional green wave coordinated control (AM-RGWCC) that can operate efficiently. The research on regional green wave coordinated control (RGWCC) has gradually become a hot spot, improving the overall operational efficiency of the control area more comprehensively and systematically. We usually encounter the difficulties of many constraints, high complexity, and low efficiency when using the modeling method to solve the RGWCC problem. AM-RGWCC is developed in this study to overcome these challenges. The overall coordinated effect is assured by realizing the comprehensive optimization of phase sequence, offset, and common signal cycle. A step-by-step design of AM-RGWCC is established to reduce the complexity by analyzing the comprehensive influence of offset difference and bias distance on the green wave bandwidth. Finally, the case study shows that for a three-by-three road network, an ideal scheme can be obtained by AM-RGWCC to maximize the green wave bandwidth in one second. The green wave bandwidth of each intersection accounts for more than 84%. The results illustrate that the coordinated effect and solving efficiency are significantly improved. The proposed algebraic method will have certain advantages in the RGWCC design of a large-scale road network.
Co-simulation Analysis of Commercial Vehicle Lateral Stability Optimization Control

： A commercial vehicle lateral stability optimization control strategy based on particle swarm optimization and neural network optimization algorithm is proposed, and upper and lower double control mode is designed, yaw rate velocity and vehicle side slip angle are taken by upper controller as the control target, according to the feedback information of vehicle driving condition, scale factor parameters of fuzzy controller is optimized by particle swarm optimization algorithm dynamically, and the front wheel additional steering angle and yawing movement control is finished. The lower controller utilizes RBF neural network algorithm to make vehicle yaw velocity deviation adaptive learning, and optimizes the allocation of left and right front wheel brake force and corrects front wheel steering angle. Vehicle lateral stability simulation analysis is conducted by typical test conditions under TruckSim and Matlab/Simulink co-simulation environment. The experiment results show that compared with traditional electronic stability control(ESC) strategy, after optimization control the dynamic response values of yaw rate velocity, vehicle side slip angle and lateral acceleration can meet the requirement, and perform well in tracking the target path, comprehensive improve the lateral stability of vehicle under low adhesion road driving conditions.
Serotipe virus Dengue di Provinsi Aceh

Abstract . WHO estimated 50 million dengue infections happen every year in the world. In Indonesia, there were 90,245 DHF cases on 2012 with 816 deaths. In the Province of Aceh, 2,269 cases happened in the same year. This study aimed to identify dengue virus serotype in Aceh. Sampling was done in Kota Banda Aceh Hospital, Kota Lhokseumawe Hospital, Kabupaten Aceh Tamiang Hospital, Kabupaten Aceh Barat Hospital, and Kabupaten Simeulue Hospital between May to December 2012. This was a clinical laboratory research with observation design using cross sectional approach. Research’s population was sample from patients with dengue clinical symptom. Using purposive sampling technique, we have collected 100 samples from the five hospitals (20 samples from each hospital). From RT-PCR, we found 16 positive samples (9 samples were DENV-4, 3 samples were DENV-1, 2 samples were DENV-2, and 2 samples were DENV-3. Keywords : dengue virus, serotype, Aceh Abstrak . WHO memperkirakan terjadi 50 juta infeksi dengue setiap tahun di seluruh dunia. Pada 2012, kasus DBD di Indonesia mencapai 90.245 kasus dengan angka kematian sebesar 816 kasus. Di Provinsi Aceh, kasus DBD pada 2012 sebesar 2269 kasus. Tujuan penelitian ini adalah untuk menentukan serotipe virus dengue di Provinsi Aceh. Pengambilan sampel dilakukan di RS Kota Banda Aceh, RS Kota Lhokseumawe, RS Kabupaten Aceh Tamiang, RS Kabupaten Aceh Barat, dan RS Kab. Simeulue. Waktu penelitian adalah Mei 2012 sampai dengan Desember 2012. Jenis penelitian ini adalah penelitian klinis laboratoris dengan desain studi observasi menggunakan pendekatan potong lintang. Populasi penelitian adalah sampel dari semua pasien dengan gejala klinis infeksi virus dengue yang berobat di RS. Jumlah sampel adalah 100 sampel masing-masing 20 sampel per rumah sakit. Penarikan sampel dilakukan dengan teknik purposive sampling. Dari 100 sampel yang terkumpul diperoleh 16 sampel yang positif pada pemeriksaan RT-PCR, terdiri dari sembilan DENV-4, tiga sampel DENV-1, dua sampel DENV-2, dan dua sampel DENV-3. Kata Kunci : virus dengue, serotipe, Aceh
Optimal pricing for cloud service providers in a competitive setting

Cloud services are transforming business and government at an ever-increasing rate. As a form of cloud service, software as a service (SaaS) is one of the fast growing segments of the information technology and has become an attractive alternative to the on-premises software. In this paper, we study the optimal pricing strategies of a cloud service provider in an incumbent-entrant setting under user upgrade cost and switching cost. Our results show that in equilibrium the market structure is not unique. The specific market segmentation depends on the incumbent’s pricing strategy whether to provide discounted price to its old customers and the levels of user upgrade cost and switching cost. When faced with customers who are heterogeneous in the sensitivity to the related costs, the incumbent firm may need to offer a discount to the new customers rather than to those who have purchased from it. This implies that the entry of a SaaS firm into the market is a potential threat to the incumbent on-premises software firm, especially in capturing new customers from the untapped market.
Dual-Band Filtering Switches Using Multimode Dielectric Resonators With Hybrid Boundaries

Miniaturized dual-band filtering switches are proposed in this article using multimode dielectric resonators (DRs). The planar printed circuit boards (PCBs) are utilized not only to construct the hybrid electromagnetic boundary for quad-mode DR, but also to offer the switchable multimode feeding structures with the p-i-n diodes. When the diodes are reversely biased, all the four modes are excited simultaneously by the mixed electric and magnetic couplings and controlled flexibly to construct the dual-band response. In this manner, extra losses from diodes are avoided, and low-loss transmission is realized. When the diodes are forward biased, all the four modes are shut off at the same time. Owing to the used mixed electric and magnetic couplings, the isolation is enhanced further by the cancellation of the electric and magnetic couplings between the feeding line and the resonant modes. For demonstration, both dual-mode and quad-mode filtering switches with dual-band operations are fabricated and tested. With only one quad-mode DR, high performance, including low-loss dual-band transmission and high-level isolation, is observed in the measurement, making the proposed switches promising in high-standard multiband time division duplex (TDD) systems.
Identifying and mitigating moral injury risks in military behavioral health providers

ABSTRACT The term “moral injury” was initially used to describe the multifaceted pain that service members feel after perpetrating, witnessing, or failing to prevent acts that conflict with their moral codes. More recently the term has been used to describe healthcare providers’ pain stemming from their experiences serving on the frontlines of the healthcare system when: a medical error causes serious harm to patients, systems continuously impede their abilities to provide proper care, or providers assess that they have acted in ways that conflict with their professional ethics or oaths to “do no harm. ” This article explores moral injury risk at the intersection of military service and healthcare by examining challenges that military behavioral healthcare providers face. Leveraging moral injury definitions previously applied to service members (personal or witnessed transgressions) and in two healthcare contexts (“second victim” to adverse client outcomes and system-driven moral distress), as well as literature on ethical challenges in military behavioral health, this paper uncovers situations that may amplify military behavioral health providers’ risks for moral injury. It concludes by offering policy and practice recommendations germane to military medicine aimed at alleviating pressures military behavioral healthcare providers face and mitigating moral injuries’ potential ripple effects on provider wellness, retention and care quality.