Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification and Characterization of Novel Genes Expressed Preferentially in the Corpora Allata or Corpora Cardiaca during the Juvenile Hormone Synthetic Period in the Silkworm,

Juvenile hormone (JH) plays important roles in insect development and physiology. JH titer is tightly regulated to coordinately adjust systemic physiology and development. Although control of JH titer is explained by the expression of JH biosynthetic enzymes in the corpora allata (CA), molecular mechanisms that regulate the expression of these genes remain elusive. In the present study, to identify novel regulators of JH biosynthetic genes, we conducted a gene expression screen using the CA and corpora cardiaca (CC) of the silkworm, Bombyx mori , in the JH synthesis period. We identified seven candidate genes and characterized their properties through extensive expression analyses. Of these candidates, we found that a novel gene, which encodes type II phosphatidylinositol 3,4-bisphosphate [PI(3,4)P 2 ] 4-phosphatase, shows highly correlated expression with JH titer. In addition, expression of this gene was strongly upregulated by starvation, when JH biosynthetic enzyme genes are concurrently upregulated. These results, for the first time, imply possible involvement of phosphoinositol signal in regulation of JH biosynthesis, providing novel insights into molecular mechanisms of nutrition-dependent regulation of JH biosynthesis.
Clustering of test scenes by use of Wasserstein metric and analysis of tracking quality in optically degraded videos

—The goal of this paper is to present results of analysis of the impact of artiﬁcially generated disturbances imitating real defects that may occur in the process of testing autonomous vehicles both during rides and later, in vehicle software simulation. We will focus on one perception module responsible for detection of other moving vehicles on the road. Injected faults are Gaussian blur, obliteration by particles and gray level resolution degradation. At the same time, we want to propose an examination approach scheme that will provide detailed information about distribution of quality in this comparative experiment and which can be reused for different perception modules, faults, scene sets and also in order to compare new releases of main recognition software. To do so we will combine statistical methods (Welch’s ANOVA) and topological analysis (Clusterization over space of distributions, Wasserstein metric). Results include summary of experiment for all used data and described by mentioned tools examples of certain cases that illustrate general conclusions and less standard outcomes.
Journal of Pure and Applied Algebra Dold–Kan correspondence for dendroidal abelian groups

We prove a Dold–Kan type correspondence between the category of planar dendroidal abelian groups and a suitably constructed category of planar dendroidal chain complexes. Our result naturally extends the classical Dold–Kan correspondence between the category of simplicial abelian groups and the category of non-negatively graded chain complexes.
PH SENSITIVE OPHTHALMIC IN SITU GEL: A REVIEW

iris eye pupil iris. ABSTRACT One of the most challenging and interesting drug delivery is Ophthalmic drug delivery for the pharmaceutical scientist. Glaucoma, dry eye syndrome, keratitis, endopthalmitis, trachoma, conjunctivitis are various problems from which eye suffer. Within the eye, an adequate amount of active ingredients must be delivered and maintained at the site of action to achieve effective ocular therapy. Conventional therapy exhibits the poor bioavailability and therapeutic response due to rapid precorneal elimination of the drug. There are considerable efforts directed towards newer drug system for ocular administration to overcome the drawbacks of conventional therapy. The use of in situ gel overcomes the problems by forming sol-gel transition when drop instilled in the eye and transition form in cul-de-sac. The review involve in-situ gel system which includes thermally triggered system, pH triggered system and ion cross linking system. The review involves detailed method of preparation and evaluation parameters of pH triggered system.
Coralline ‐ like Ni 2 P decorated novel tetrapod ‐ bundle Cd 0.9 Zn 0.1 S ZB/WZ homojunctions for highly efficient visible ‐ light photocatalytic hydrogen evolution

In this study, Ni 2 P‐Cd 0.9 Zn 0.1 S (NPCZS) composites were synthesized by coupling tetrapod bundle Cd 0.9 Zn 0.1 S (CZS) and coralline‐like Ni 2 P (NP) via a simple calcination method. CZS shows outstand‐ ing activity in photocatalytic hydrogen evolution (1.31 mmol h ‒1 ), owing to its unique morphology and heterophase homojunctions (ZB/WZ), which accelerate the separation and transfer of photo‐ generated charges. After coupling with NP, the photoactivity of NPCZS was enhanced, and the max‐ imum hydrogen evolution rate of 1.88 mmol h ‒1 was reached at a NP content of 12 wt%, which was 1.43 times higher than that of pure CZS. The experimental results of the photocatalytic activity, viz. photoluminescence spectra, surface photovoltage spectra, and electrochemical test showed that the enhanced photoactivity of NPCZS should be attributed to the synergistic effects of the novel tetra‐ pod‐bundle morphology, heterophase homojunctions, and decoration of the NP co‐catalyst. Moreo‐ ver, the as‐prepared NPCZS composites exhibited excellent photostability and recyclability. Herein, we propose a possible mechanism for the enhanced photocatalytic activity. © 2021, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.
EFFECT OF LOCAL CASSAVA FERMENTATION METHODS ON FUNCTIONAL, PASTING AND SENSORY PROPERTIES OF LAFUN

The effects of two fermentation methods (fixed and unfixed methods) and fermentation periods (48h, 72h, 96h) on the HCN content, texture, colour, flavour, water retention capacity, bulk density and rheological properties of lafun were studied. Result obtained showed that the HCN content of lafun obtained through the method of leaving fermentation water was significantly lower (0.006%-0.004%) than when the fermentation was changed regularly (0.014%-0.010%). On the other hand bulk density and water retention capacity were significantly higher in lafun processed by method of leaving the fermentation water constant (bulk density 1.742g/cm 3 –1.823g/cm 3 ), (water absorption capacity (0.607gg -1 – 1.271gg -1 ). It was also observed that the longer the period of fermentation, the higher the values for the bulk density and water absorption capacity. Texture, appearance and flavour were not significantly different in lafun processed from the two fermentation methods but there was a significant difference in the periods used for the fermentation with the ones fermented for longer period being more preferred.
The irritation of doubt: When is it OK to scratch your beliefs?

Building upon Peirce’s notion of “the irritation of doubt”, I outline the role doubts play in belief formation, drawing a distinction between two di ﬀ erent phenomena: Peircean doubts and scary doubts. I argue that the former are an essential and useful ingredient in our belief dynamics, whereas the latter are potentially dangerous and yet unavoidable biases, even though they might occasionally be redeemed by their practical merits. This analysis is intertwined with Castelfranchi’s views on belief formation and goal processing, with the aim of highlighting a common root between pragmatism and goal theory, and to provide a unifying picture of the mind as a goal-directed, coherence-seeking control system.
Pushing with a group of mobile robots

—This work addresses the problem of manipulating an object on a plane using a group of robots in a collaborative way, applying only pushing actions. The proposed method exploits well known control methods from the robotic literature in designing a multi-layered control algorithm to steer the group of robots in the planar environment to perform a pushing action. The proposed approach is extensively validated by means of simulations and real world experiments involving different objects and robot groups with different numerosity.
Laser Ablation of Biomaterials Laser Ablation of Biomaterials

Biomaterials, defined by high biocompatibility and biodegradability, are intensively used in medical applications, mainly to replace partial or total, damaged or destroyed hard or soft tissues. Most of them are used not only as coatings for implant coverage but also as parts for some medical devices. In the last decades, researchers sought to find the optimum processing methods and parameters to modify or deposit the biomaterial of interest. An important family of techniques, used to process a biomaterial, is represented by laser techniques, based upon laser ablation phenomenon. Laser ablation of biomaterials ensures the transference or modification with good precision and without or with minimal disruptions generated. To obtain thin coatings from biomaterials, one can use deposition techniques: pulsed laser deposition (PLD) or matrix-assisted pulsed laser evaporation (MAPLE). These techniques are chosen according to the selected biomaterial and desired performances of the obtained coating. Therefore, some sensitive biomaterials can be transferred only by MAPLE. Some results in the field of calcium phosphates deposited by PLD or MAPLE are presented, proving the usefulness of these biomaterials for medical applications.
The coronary artery calcium score is linked to plasma cholesterol synthesis and 1 absorption markers: Brazilian Longitudinal Study of Adult Health 2

It is controversial whether atherosclerosis is linked to increased intestinal cholesterol absorption or synthesis in humans. The aim of this study was to relate atherosclerosis to the measurements of plasma markers of cholesterol synthesis 21 (desmosterol, lathosterol) and absorption (campesterol, sitosterol). In healthy male 22 (n=344), non-obese, non-diabetics, belonging to the city of São Paulo branch of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), we measured in plasma 24 these non-cholesterol sterol markers, together with their anthropometric, dietary 25 parameters, traditional atherosclerotic risk factors, and blood chemistry, coronary 26 arterial calcium score (CAC), and ultrasonographically measured common carotid artery 27 intima-media thickness (CCA-IMT). Cases with CAC>zero had the following 28 parameters higher than cases with CAC=zero: age, waist circumference (WC), plasma 29 total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and non-high density 30 lipoprotein-cholesterol (non HDL-C). Plasma desmosterol and campesterol, duly 31 corrected for TC, age, body mass index (BMI), waist circumference (WC), hypertension, 32 smoking, and the homeostasis model assessment-insulin resistance (HOMA-IR) 33 correlated with CAC, but not with CCA-IMT . The latter related to increased age, BMI, 34 waist circumference (WC), and systolic blood pressure (SBP). Plasma HDL-C 35 concentrations did not define CAC or CCA-IMT degrees, although in relation to the 36 lower tertile of HDL-C in plasma the higher tertile of HDL-C had lower HOMA-IR and 37 concentration of a cholesterol synthesis marker (desmosterol). Present work indicated 38 that increased cholesterol synthesis and absorption represent primary causes of CAD, 39 but not of the common carotid
Complementary dynamic BH3 profiles predict co-operativity between the multikinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells Please share how this access benefits you. Your story matters

Direct co-operation between sensitiser molecules BAD and NOXA in mediating apoptosis suggests that therapeutic agents which sensitise to BAD may complement agents which sensitise to NOXA. Dynamic BH3 profiling is a novel methodology that we have applied to the measurement of complementarity between sensitiser BH3 peptide mimetics and therapeutic agents. Using dynamic BH3 profiling, we show that the agent TG02, which downregulates MCL-1, sensitises to the BCL-2-inhibitory BAD-BH3 peptide, whereas the BCL-2 antagonist ABT-199 sensitises to MCL-1 inhibitory NOXA-BH3 peptide in acute myeloid leukaemia (AML) cells. At the concentrations used, the peptides did not trigger mitochondrial outer membrane permeabilisation in their own right, but primed cells to release Cytochrome C in the presence of an appropriate trigger of a complementary pathway. In KG-1a cells TG02 and ABT-199 synergised to induce apoptosis. In heterogeneous AML patient samples we noted a range of sensitivities to the two agents. Although some individual samples markedly favoured one agent or the other, in the group as a whole the combination of TG02 + ABT-199 was significantly more cytotoxic than either agent individually. We conclude that dynamic NOXA and BAD BH3 profiling is a sensitive methodology for investigating molecular pathways of drug action and complementary mechanisms of chemoresponsiveness.
The internal kinematics of the giant extragalactic H II complex NGC 604.

On a obtenu 14 spectres coudes a longue fente du complexe HII geant NGC 604 de M33. Ils couvrent les raies d'emission nebulaires de [NII], Hα et [SII] entre 6470 et 6790 A sur une zone de 2'×2'. On verifie l'existence de mouvements hautement supersoniques dans le gaz ionise. La complexite du champ des vitesses dans NGC 604 semble decouler directement de sa morphologie chaotique
Impacts of widespread badger culling on cattle tuberculosis a

Background: Bovine tuberculosis (TB) has re-emerged as a major problem for British cattle farmers. Failure to control the infection has been linked to transmission from European badgers; badger culling has therefore formed a component of British TB control policy since 1973. Objectives and design: To investigate the impact of repeated widespread badger culling on cattle TB, the Randomised Badger Culling Trial compared TB incidence in cattle herds in and around ten culling areas (each 100 km 2 ) with those in and around ten matched unculled areas. Results: Overall, cattle TB incidence was 23.2% lower (95% conﬁdence interval (CI) 12.4—32.7%
Gas Detection of Different Polarity Molecules by Capacitive Sensors Based on Zeolites

A 4294A precision impedance analyser was used to measure the sensors response to different analytes. The impedance analyser works with a frequency range of 40Hz - 110MHz with a resolution of 1mHz. It works by taking sweeped measurements of voltages and frequencies to see the behaviour of a load. It was connected to the sensors using 4 different wires. This was used to cancel out large parasitic effects. The voltage and frequencies were introduced into the sensor and the response is recorded.
A REVIEW OF HISTORY OF SECOND LANGUAGE LEARNING MOTIVATION THEORIES

The motivation plays a very important role in the successful of language learning process. Fully knowing the the existing and existed theories in order of time can help learner and teacher deeply understand the evolution of motivations. By paying attention to every aspect which mentioned in the previous research can affect learning process, teachers and learners can choose the most suitable way to motivate their students or themselves to improve the learning process. This review is written in goal of contributing to the development of language learning and teaching through providing the information of the evolution of language learning motivation theories.
Identification of the Fungal Postharvest Disease on Peach Fruits

This study investigated the fungi associated with the spoilage of the most world-popular fruits cultivated commercially, namely peach, although its botanical name is (Prunus persica (L.) Batsch) belongs to the family Rosaceae. A total of 500 mixed samples of peach fruits were collected. The spoilage peaches fungi were isolated, characterized and identified. The fungi isolated and identified from the spoiled peaches were, Monilinia fructicola, Sphaerotheca sp, Alternaria tenuis, Aspergillus niger, Aspergillus flavus, Botryodiplodia sp, Cladosporium carpophilum, Penicillium sp, Rhizopus sp and Trichothecium sp. The most prevalent fungi isolated from the samples and found in all samples collected from peach fruits and caused severe postharvest losses were Aspergillus sp, Penicillium sp and Rhizopus sp and considered as the main species that cause the postharvest disease infection of peach fruits The study showed that the presence of these fungi associated with peach spoilage caused high risk to humans and animals due to they produce microbial toxins or presence pathogenic microorganisms in food products, which lead to food poisoning. The suitable and proper technology in each harvesting steps must apply in order to minimize the contamination of these microorganisms and maintain good quality during harvesting, grading, cleaning, packaging and transportation.
Comparison of Salmonella enterica serovars Typhi and Typhimurium reveals typhoidal- 1 specific responses to bile 2

Salmonella enterica 19 respectively. A unique feature of typhoid infection is asymptomatic carriage within the 20 gallbladder, which is linked with S . Typhi transmission. Despite this, S . Typhi responses to 21 bile have been poorly studied. RNA-Seq of S . Typhi Ty2 and a clinical S . Typhi isolate 22 belonging to the globally dominant H58 lineage (129-0238), as well as S . Typhimurium 23 14028, revealed that 249, 389 and 453 genes respectively were differentially expressed in the 24 presence of 3% bile compared to control cultures lacking bile. fad genes, the actP-acs 25 operon, and putative sialic acid uptake and metabolism genes (t1787-t1790) were upregulated 26 in all strains following bile exposure, which may represent adaptation to the small intestine 27 environment. Genes within the Salmonella pathogenicity island 1 (SPI-1), encoding a type 28 IIII secretion system (T3SS), and motility genes were significantly upregulated in both S . 29 Typhi strains in bile, but downregulated in S . Typhimurium. Western blots of the SPI-1 30 proteins SipC, SipD, SopB and SopE validated the gene expression data. Consistent with this, 31 bile significantly increased S . Typhi HeLa cell invasion whilst S . Typhimurium invasion was 32 significantly repressed. Protein stability assays demonstrated that in S . Typhi the half-life of 33 HilD, the dominant regulator of SPI-1, is three times longer in the presence of bile; this 34 increase in stability was independent of the acetyltransferase Pat. Overall, we found that S . 35 Typhi exhibits a specific response to bile, especially with regards to virulence gene 36 expression, which could impact pathogenesis and transmission. aim this study to compare global bile responses between S. Typhi and S . Typhimurium isolates, which might explain differences in pathogenesis and reveal 93 processes for the carrier state.
Basic Components for Building Column Store-based Applications

—A constantly increasing CPU-memory gap as well as steady growth of main memory capacities has increased interest in column store systems due to potential performance gains within the realm of database solutions. In the past several monolithic systems have reached maturity in the commercial and academic space. However a framework of low-level and modular components for rapidly building column store based applications has yet to emerge. A possible ﬁeld of application is the rapid development of high-performance components in various data-intensive areas such as text-retrieval systems. The main contribution of this paper is column-store-kit, a basic building block of low-level components for constructing applications based on column store principles. We present a minimal amount of necessary structural elements and associated operations required for building applications based on our column-store-kit.
Neuronal CXCL10 Directs CD8 (cid:1) T-Cell Recruitment and Control of West Nile Virus Encephalitis

The activation and entry of antigen-speciﬁc CD8 (cid:1) T cells into the central nervous system is an essential step towards clearance of West Nile virus (WNV) from infected neurons. The molecular signals responsible for the directed migration of virus-speciﬁc T cells and their cellular sources are presently unknown. Here we demonstrate that in response to WNV infection, neurons secrete the chemokine CXCL10, which recruits effector T cells via the chemokine receptor CXCR3. Neutralization or a genetic deﬁciency of CXCL10 leads to a decrease in CXCR3 (cid:1) CD8 (cid:1) T-cell trafﬁcking, an increase in viral burden in the brain, and enhanced morbidity and mortality. These data support a new paradigm in chemokine neurobiology, as neurons are not generally considered to generate antiviral immune responses, and CXCL10 may represent a novel neuroprotective agent in response to WNV infection in the central nervous system.
biology Repurposing of Antibiotic Sulﬁsoxazole Inhibits Lipolysis in Pre-Clinical Model of Cancer-Associated Cachexia

Simple Summary: A large number of advanced cancer patients suffer from a gradual weight loss manifested as muscle and fat loss. This condition is known as cancer-associated cachexia. Cachexia limits tolerance of anti-cancer treatments, surgeries, and quality of life of individual who have cancer. Unfortunately, there are no potential agents available to treat cancer-induced cachexia. Here, we investigated the efﬁcacy of the drug Sulﬁsoxazole in both cell and animal-based experiments. Our results demonstrated that upon treatment with Sulﬁsoxazole there was partial reduction of fat loss and improved overall well-being of the mice with cancer cachexia. Furthermore, cell-based analysis revealed that Sulﬁsoxazole reduces the loss of fat cells size and number. Thus, oral administration of Sulﬁsoxazole could be a promising means for the treatment of cancer-associated cachexia if it is combined with agents that could potentially inhibit muscle loss and/or anti-cancer agents. Abstract: Clinical management of cancer-associated cachexia, a multi-organ wasting syndrome, has been challenging without effective treatment strategies. An effective treatment that directly targets cancer-induced wasting is desperately needed to improve the quality of life and the survival of cancer patients. Recently, an antibiotic SFX was shown to have anti-tumour and anti-metastatic effects in mouse models of breast cancer. Hence, in this study, we examined the efﬁcacy of SFX in the treatment of cancer-induced cachexia. C26 cachexic mice models were administered with SFX, and the tumour volume and body weight were regularly measured. Blood glucose, skeletal muscles, and adipose tissue were examined at the endpoint. Contrary to a previous study, SFX did not reduce the tumour volume in mice bearing C26 cells. Administration of SFX neither revealed any survival beneﬁt nor rescued C26 cachectic mice from muscle wasting. Interestingly, SFX administration partially rescued (~10%) tumour-induced weight loss by preserving both the subcutaneous and intestinal fat mass. Together, these results suggest that the administration of SFX could partially rescue cancer-induced weight loss by inhibiting lipolysis. As anti-cachexia therapies are scarce, the results could facilitate the design of combinatorial therapies involving SFX, standard-of-care chemotherapeutics, and drugs that inhibit muscle atrophy for the treatment of cancer cachexia.
Mesoarchean to Mesoproterozoic Re-Os ages for sulfide inclusions in Orapa diamonds and implications for Kaapvaal-Zimbabwe craton development

Sulfide inclusions found in single macro-diamonds from the Orapa kimberlite have been studied to better understand the age spectrum of eclogitic diamond growth in southern Africa and its relationship to craton evolution. Detailed information at the western side of the Kaapvaal-Zimbabwe system and particularly that which might pertain to the subcontinental lithospheric mantle (SCLM) of the Zimbabwe craton is scarce.