Miracle-dz/UniFAR-FTUs huggingface dataset:
Robust Behrens–Fisher Statistic Based on Trimmed Means and Its Usefulness in Analyzing High-Throughput Data

In the context of high-throughput data, the differences in continuous markers between two groups are usually assessed by ordering the p-values obtained from the two-sample pooled t-test or Wilcoxon–Mann–Whitney test and choosing a stringent cutoff such as 10–8 to control the family-wise error rate ( F W E R ) or false discovery rate ( F D R ) . All markers with p-values below the cutoff are declared to be significantly associated with the phenotype. This inherently assumes that the test procedure provides valid type I error estimates in extreme tails of the null distribution. The aforementioned tests assume homoscedasticity in the two groups, and the t-test further assumes underlying distributions to be normally distributed. Cao et al. (Biometrika, 2013, 100, 495–502) have shown that in the context of multiple hypotheses testing the approach based on F D R may not be valid under non-normality and/or heteroscedasticity. Therefore, having a test statistic that is robust to these violations is needed. In this study, we propose a robust analog of Behrens–Fisher statistic based on trimmed means, conduct an extensive simulation study to compare its performance with other competing approaches, and demonstrate its usefulness by applying it to DNA methylation data used by Teschendorff et al. (Genome Res., 2010, 20, 440–446). An R program to implement the proposed method is provided in the Supplementary Material.
CENP-A Regulation and Cancer

In mammals, CENP-A, a histone H3 variant found in the centromeric chromatin, is critical for faithful chromosome segregation and genome integrity maintenance through cell divisions. Specifically, it has dual functions, enabling to define epigenetically the centromere position and providing the foundation for building up the kinetochore. Regulation of its dynamics of synthesis and deposition ensures to propagate proper centromeres on each chromosome across mitosis and meiosis. However, CENP-A overexpression is a feature identified in many cancers. Importantly, high levels of CENP-A lead to its mislocalization outside the centromere. Recent studies in mammals have begun to uncover how CENP-A overexpression can affect genome integrity, reprogram cell fate and impact 3D nuclear organization in cancer. Here, we summarize the mechanisms that orchestrate CENP-A regulation. Then we review how, beyond its centromeric function, CENP-A overexpression is linked to cancer state in mammalian cells, with a focus on the perturbations that ensue at the level of chromatin organization. Finally, we review the clinical interest for CENP-A in cancer treatment.
Gait Parameters and Peripheral Neuropathy in Patients With Diabetes: A Meta-Analysis

Objective To investigate the relationship between diabetic peripheral neuropathy (DPN) and gait abnormality in diabetic patients. Methods Related research concerning the gait of diabetic patients with and without DPN was collected and analyzed by searching PubMed, Embase, and Web of Science. Statistical analysis was performed by using RevMan 5.3 software. Results Twenty-one studies were included in this meta-analysis, consisting of 499 diabetic neuropathy patients and 467 diabetes controls without neuropathy. Meta-analysis results showed lower gait velocity, shorter stride length, longer stride time, longer stance time, and higher maximum knee extension moment in the DPN group, compared with their counterparts. Conclusion Among diabetic patients, those complicated with DPN possess lower gait velocity, shorter stride length, longer stride time, longer stance time, and higher maximum knee extension moment.
Tobacco Treatment Outcomes for Hospital Patients With and Without Mental Health Diagnoses

Background The prevalence of mental health conditions is higher in cigarette smokers than nonsmokers. However, those with diagnosed mental health disorders are understudied within general inpatient hospital settings. This study seeks to evaluate how having a mental health diagnosis influences response to a brief opt-out inpatient tobacco treatment intervention. Methods Data included 4,153 admitted patients who completed a tobacco treatment visit. Post-discharge self-reported abstinence was obtained via response to an automated call 1-month after discharge. Mental health co-morbidities were assessed by reviewing electronic medical records. Logistic regression was used to assess associations between having a mental health diagnosis and patients' smoking history, interest in quitting smoking, and post-discharge abstinence. Results Overall 34.1% of patients were diagnosed with mental health disorders, most commonly depression or substance use disorders. Patients with a diagnosed mental health disorder were more likely to report a history of long-term heavy smoking and were less likely to express an interesting in remaining abstinent from smoking after hospitalization. An intent-to-treat analysis using logistic regression analysis found lower rates of self-reported smoking abstinence in those with a mental health disorder compared to those without (9 vs. 13.2%, p < 0.001). Conclusions Patients with a history of mental health diagnoses, such as depression or substance use disorders, was associated with lower rates of smoking abstinence in patients after hospitalization. Hospital based opt-out smoking cessation programs have shown to be generally effective and efficient. However, certain subpopulations may require tailored intervention in order to improve treatment outcomes. Future research is needed to develop brief, effective tobacco treatment for hospital patients with comorbid mental health diagnoses.
Automatic Speech Recognition System

Speech recognition is one of the next generation technologies for human-computer interaction. Speech recognition has been researched since the late 1950s but due to its computational complexity and limited computing capabilities of the last few decades, its progress has been impeded. In laboratory settings automatic speech recognition systems (ASR) have achieved high levels of recognition accuracies, which tend to degrade in real world environments. This paper analyses the basics of the speech recognition system. Major problems faced by ASR in real world environments have been discussed with major focus on the techniques. These technique used in the development of noise robust ASR
Generation of Non-Repetitive Everyday Impact Sounds for Interactive Applications

The use of high quality sound effects is growing rapidly in multimedia, interactive and virtual reality applications. The common source of audio events in these applications is impact sounds. The sound effects in such environments can be pre-recorded or synthesized in real-time as a result of a physical event. However, one of the biggest problems when using pre-recorded sound effects is the monotonous repetition of these sounds which can be tedious to the listener. In this paper, we present a new algorithm which generates non-repetitive impact sound effects using parameters from the physical interaction. Our approach aims to use audio grains to create finely-controlled synthesized sounds which are based on recordings of impact sounds. The proposed algorithm can also be used in a large set of audio data analysis, representation, and compression applications. A subjective test was carried out to evaluate the perceptual quality of the synthesized sounds.
Analysis of the relation of remuneration with the effectiviness of business operatons of enterprises-sectorial and sectional views

Correspondence to: Kamil Mazurkiewicz Uniwersytet Marii Curie-Skłodowskiej w Lublinie Wydział Ekonomiczny Katedra Finansów Przedsiębiorstw i Rachunkowości plac Marii Curie-Skłodowskiej 5 20-031 Lublin, Poland Tel. : +48 81 537 55 29 E-mail: kamil.mazurkiewicz@ poczta.umcs. lublin.pl Abstract: This article deals with the issue of linking remuneration with the effectiveness of business operations. The aim of the study was to determine the strength and direction of the relation between remuneration and the effectiveness of economic activity, taking into account its various measures as well as sectorial and sectional division of the Polish economy. For this purpose, data from the Central Statistical Office for the years 2005–2017 was used for values classified as total, public and private sector in addition to PKD (Polish Classification of Activities) sections. To determine the relation in the study, Pearson’s correlation coefficient was used, which was estimated for the relation of remuneration between work efficiency (based on revenues from total activity and net financial result) and profitability (assets, equity, revenues from total activity). Three of the four hypotheses were verified as negative. First, the remuneration was not always related to the effectiveness of business operations. Secondly, the increase in the efficiency of business operations was not always accompanied by an increase in wages. Thirdly, the salary was not always the strongest link to labour productivity. The only positively verified hypothesis was the one which assumed sectorial and sectional differentiation of the relation between remuneration and individual measures of effectiveness of business activity.
FAT SOURCES IN DIETS FOR FEEDLOT-FINISHED STEERS-CARCASS AND MEAT CHARACTERISTICS

The object of this study was to compare the effect of different sources of fat in the diet for feedlot steers on carcass and meat characteristics. Twenty steers were distributed into four treatments: BC – basic concentrate; IRB – basic concentrate + rice bran + rice oil; M3 basic concentrate + 3% of fatty acids calcium salts; and M6 – basic concentrate + 6% of fatty acids calcium salts. Previously to slaughter, the animals were submitted to a 14-hour fasting and were weighted to obtain slaughter weight. A slaughter was carried out in a commercial slaughterhouse and followed normal slaughter flow. The complete randomized block experimental design was used, with four treatments and five replications, being the animals’ genetic group the blocking criteria. The highest fat accumulation was found in carcasses of animals from M6 treatments (5.21mm). Animals that consumed 6% of fatty acid calcium salts showed carcass with higher edible portion (6.31 vs. average of 5.7, respectively, for M6 and others treatments). The inclusion of fatty acids calcium salts in the diet improved carcass finishing and increased carcass total fat content. The inclusion of rice bran and oil or fatty acid calcium salts did not change animal’s meat characteristics.
ДИНАМИКА НАУЧНЫХ ПУБЛИКАЦИЙ ПО ПРИМЕНЕНИЮ НАНОЧАСТИЦ И НАНОСТРУКТУР ДЛЯ АДРЕСНОЙ ДОСТАВКИ ЛЕКАРСТВЕННЫХ ВЕЩЕСТВ DYNAMICS OF SCIENTIFIC PUBLICATIONS ON THE USING OF NANOPARTICLES AND NANOSTRUCTURES FOR TARGETED DRUG DELIVERY

Н. М. Мурашова, к. х. н. , доц. (ORCID: 0000-0003-1284-5302), Е. С. Трофимова (ORCID: 0000-0001-5584-4612), Е. В. Юртов, член-корр. РАН, д. х. н. , проф. , заведующий кафедрой наноматериалов и нанотехнологии (ORCID: 0000-0002-4972-6625), Российский химико-технологический университет им. Д. И. Менделеева / namur_home@mail.ru N.M. Murashova, Candidate of Chemical Sciences, Docent (ORCID: 0000-0003-1284-5302), E.S. Trofimova (ORCID: 0000-0001-5584-4612), Е. V.Yurtov, Corresponding Member of the Russian Academy of Sciences, Doctor of Chemical Sciences, Professor, Head of Department of Nanomaterials and Nanotechnologies (ORCID: 0000-0002-4972-6625), D.Mendeleev University of Chemical Technology of Russia
Co-creating with children : arts and crafts toys

This project is executed on behalf of company X and aims to create a set of guidelines with which they can navigate the market of arts and crafts products. Arts and crafts are creative activities aiming to create or decorate an object, improving a child's cognitive and fine motor skills. Children develop their art skills as they age, their work becoming increasingly realistic. When designing products for children it is important to take into account their abilities. The target group of arts and crafts toys is very broad, as it includes all children aged 1-12 and their parents or guardians. Girls tend to take an interest in arts and crafts earlier than boys, due to their more advanced fine motor skill on a young age and less aggressive nature. This creates the stereotype that arts and crafts are a girly trade; however, no evidence exist of girls being more creative. Arts and crafts is a trendy category of toys where products often lose their popularity after a couple of years due to their affinity for licence deals. All successful new products have in common that they are either innovative or are sold under licences. Other influential features are collectability, low prices, and a variety in creative possibilities, but the most influential feature of all is what the child wants. The complete market of arts and crafts products has been divided into 8 categories, Figure 0, that have been rated on various categories, like price, popularity and competition. The categories with the lowest average price are Stamps & Stickers and Fashion & Jewellery. Drawing & Painting and Modelling contain the most bestsellers, while Drawing & Painting and Stamps & Stickers are the categories with the most competition. Part of this research was to examine the possibilities of co-creation in the design process. There are four main forms of co-creation, feedback sessions, brainstorm sessions, design workshops and customisation. For a feedback or brainstorm session, it is important to have clear objectives and a test structure to fall back on. Design workshops entail actively inviting children to be part of the design process. They can function as an idea generation or an insight in children's preferences and experiences. Customisation is an attractive option in the toy industry, especially in the arts and crafts market. When customers have the option to make a product their own they will feel more connected to the product and the brand. Easiest to implement is adaptive customisation, a standard product that the user can customise. Abstract 1. Drawing & Painting 2. Modelling 3. Mosaics 4. Fashion & Jewellery 5. Stamps & Stickers 6. Needlework 7. Crafting Sets 8. Supplies Figure 0 Arts and crafts
Recent Advances in Treatment of Recurrent Spontaneous Abortion

Importance Recurrent spontaneous abortion (RSA) is a distressing condition experienced by approximately 1% of women trying to conceive. However, the treatment of RSA is a challenge both for clinicians and patients. Objective The aim of this review is to discuss the medical and surgical approach to the management of RSA, including those caused by anatomical, genetic, male, infectious, endocrine, and immune factors. Evidence Acquisition A literature search using MeSH terms for each topic was undertaken using PubMed, supplemented by hand searching for additional references. Retrieved articles were reviewed, synthesized, and summarized. Results Available treatments target hypothetical risk factors for RSA, although the effectiveness of many treatment options is controversial. Intervention should depend on the benefit-to-risk ratio of the proposed treatment. Conclusions and Relevance The etiology of RSA is heterogeneous, and patients often lack specific clinical manifestations, which has hindered the progress in predicting and preventing RSA to some extent. Despite intensive workup, at least 50% of couples do not have a clear underlying pathology. In addition, an evidence-based treatment is not available in most patients even if abnormal test results are present. Many new treatment directions are also still actively exploring; empirical and combined multiple treatments are still the main methods. Target Audience Obstetricians and gynecologists, family physicians. Learning Objectives After completing this activity, the learner should be better able to describe common risk factors for RSA; formulate individualized treatment plans to improve pregnancy outcomes; and propose supportive treatment recommendations for patients with unclear causes.
Effect of Postoperative Hormonal Suppression on Fertility in Patients With Endometriosis After Conservative Surgery

Postoperative hormonal suppression is effective in increasing pregnancies when administered for at least 3 months or when gonadotropin-releasing hormone agonists are used. OBJECTIVE: To evaluate the effect of hormonal suppression on fertility when administered to infertile patients or patient wishing to conceive after surgery for endometriosis. DATA SOURCES: A systematic search of MEDLINE, EMBASE, CENTRAL and ClinicalTrials.gov was performed by two independent reviewers from the databases' inception until December 2020. METHODS OF STUDY SELECTION: We included randomized controlled trials comparing any suppressive hormonal therapy to an inactive control (placebo or absence of treatment) after conservative surgery for endometriosis. Studies that did not report fertility outcomes after surgery were excluded. TABULATION, INTEGRATION AND RESULTS: This systematic review and meta-analysis was registered in PROSPERO. Two reviewers extracted data and assessed the risk of bias as well as the strength of evidence using GRADE (Grading of Recommendations, Assessment, Development and Evaluation) methodology. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines were followed. Relative risks (RRs) were pooled by quantitative random effect meta-analysis. From 3,138 citations, 19 trials (2,028 patients) were included. Overall, no difference was observed between the treatment and the control group for pregnancy (RR 1.15; 95% CI 1.00–1.32) and live births (RR 1.05; 95% CI 0.84–1.32). When pooling all hormonal therapies, the duration of administration of postoperative therapy was identified as a substantial source of heterogeneity between studies (I2 difference=74%) with increased chances of pregnancy compared with control when administered for at least 3 months (RR 1.22; 95% CI 1.04–1.43). Gonadotropin-releasing hormone (GnRH) agonists (14 trials, 1,721 patients) were associated with increased chances of pregnancy compared with placebo or no treatment (RR 1.20; 95% CI 1.03–1.41; I2=25%). Data were limited for other hormonal treatments with no significant difference between groups. Subgroup analyses taking into account the use of fertility treatments (insemination or in vitro fertilization), stages of the disease and risk of bias of included trials did not modify the results. CONCLUSION: Postoperative hormonal suppression should be considered on a case-by-case basis to enhance fertility while balancing this benefit with the risks of delaying conception. If chosen, GnRH agonists would be the treatment of choice, and a duration of at least 3 months should be favored. SYSTEMATIC REVIEW REGISTRATION: PROSPERO, CRD42021224424.
Play experiences from childhood in adults with visual disabil- ity, motor disability and Asperger syndrome

The aim of this study is to analyze and describe how adults with visual disability, motor disability and Asperger syndrome retrospectively identify and experience play in their childhood. Fifteen adults, aged 25 to 76 years, were interviewed about their play experiences. A qualitative approach was adopted with the aim to describe qualitatively different experiences of play. The findings indicate that play experiences merge like mirror images with participation and exclusion as two divergent sides of play. The data suggest that niches for play experiences include three components related to participation and exclusion: a personal component, a social component and an environmental component. Type of disability is one of many aspects making up the three components without being a central feature within any of the components. Type of disability affects personal characteristics and preferences, form of social interaction and the environmental requirements for participating in play but not the experience of play per se. Unique to this study is the importance assigned to the concept of niche. Perceived niches are based on memories and also influence the construction of memories. Thus, they function as a link between perceptions of experiences of play from childhood to
Finite-Time <formula><tex>$\mathcal{H}_{\infty }$</tex></formula> State Estimation for PDT-Switched Genetic Regulatory Networks with Randomly Occurring Uncertainties

This paper is concerned with the problem of finitetime H∞ state estimation for switched genetic regulatory networks with randomly occurring uncertainties. The persistent dwell-time switching rule, as a more versatile class of switching rules, is considered in this paper. Besides, several random variables that obey the Bernoulli distribution are used to represent randomly occurring uncertainties. The overriding purpose of this paper is to design an estimator to ensure that the estimation error system is stochastically finite-time bounded and satisfies the H∞ performance. Based on this, sufficient conditions for the explicit form of the estimator gains can be obtained by the Lyapunov method. Finally, a numerical example is given to verify the correctness and feasibility of the proposed method.
Initial Feasibility Studies on Wireless Insufflation of the GI Tract

jenna.l. toennies@vanderbilt.edu http://research.vuse. vanderbilt.edu/MEDLab/index.htm Initial Feasibility Studies of Wireless Insufflation of the GI Tract Jenna L. Toennies*, Gastone Ciuti+, Byron F. Smith*, Pietro Valdastri+, Arianna Menciassi+, and Robert J. Webster III* *Medical & Electromechanical Design Laboratory, Vanderbilt University, Nashville, TN, USA +Center of Research In Microengineering, Scuola Superiore Sant'Anna, Pisa, Italy
Paper in the ATRS Special Issues

The purpose of this study is to clarify the impact of low cost carriers (LCCs) on non-aeronautical revenues in 26 UK airports from 1999 to 2008. Increasingly non-aeronautical revenues have become an important source for airport revenue. Our literature review highlights that there is little consensus in empirical results concerning LCC impact on non-aeronautical revenues, some of these report positive impact while others show negative impact. We estimate a non-aeronautical revenue function which includes frequency share of LCC, Air Transport Movements (ATMs), number of passengers and population of hinterland of each observed airports as explanatory variables. In addition to this, we produce marginal revenue estimates for both the case of capacity constrained and capacity unconstrained circumstance in airports. As a result, in the case of a non-capacity constrained airport, on average, the marginal revenue of an additional LCC ATM is £147 while for non-LCC ATM it is £226. On the other hand, in the case of a capacity constrained airport, on average, substituting one non-LCC ATM with an LCC ATM reduces revenue by £79.
EvEel (evolutionary ecology based model for eel): a model to explore the role of phenotypic plasticity as an adaptive response of three temperate eels to spatially structured environments

Anguilla anguilla , A. japonica and A. rostrata are three largely distributed catadromous and semelparous species characterized by a long and passive oceanic larval drift between their marine spawning grounds and their nursery areas in continental waters. Their large and spatially heterogeneous environments combined with population panmixia and long and passive larval drift impair the possibility of local adaptation and favour the development of phenotypic plasticity. In this context, we develop EvEel, a model that aims at exploring the role of phenotypic plasticity as an adaptive response of eels. Results suggest that the spatial patterns in terms of sex-ratio, length-at-silvering and habitat use observed at both the distribution area and the river catchment scales may actually be the result of three adaptive mechanisms to maximize individual fitness in spatially structured environments. We think that considering phenotypic plasticity as a paradigm is required to develop appropriate models for this species.