Miracle-dz/UniFAR-FTUs huggingface dataset:
Load-settlement analysis for bored piles using hyperbolic transfer functions.

A practical method for analyzing the load-settlement behaviour of bored cast-in-place plies has been proposed. The method employs Kondner-type hyperbolic load-transfer functions, by which non-linear behaviour can be simulated plainly and simply, for skin resistance and end resistance. The parameters required may be determined from the results of usual in-situ and/or laboratory tests. The procedure for determining the parameters is discussed in detail : It is indicated that displacements needed to mobilize half of the ultimate skin resistance are as small as 1/100 of those of the ultimate end resistance. One-dimensional finite element formulation, which personal computers are enough to solve, for the model proposed is described. Analytical results of loading tests for large-diameter bored piles are discussed. The method proposed may be useful for the following situations : the preliminary analysis for planning an appropriate loading-test program and the back analysis of loading tests for optimizing the design.
Indications, Contraindications, and Clinical Significance of Holter Monitoring Device

Holter electrocardiogram monitoring devices are mainly indicated to assess the 24-hour heart rate and rhythm, enabling clinicians and physicians to evaluate the underlying disorders, possibly arrhythmias. The clinical significance of these modalities was apparent in different clinical events, including cardiac and non-cardiac ones. Many applications and clinical advantages were reported since the device was first reported, which changed the way how healthcare settings deal with and monitor cardiac rhythm and associated abnormalities. Evidence shows that Holter monitoring devices are useful in the appropriate patient populace and are very efficacious in diagnosing and following cardiac arrhythmias and other different cardiac conditions, which can significantly enhance the prognosis and management of cardiovascular patients. In this context, it has been shown that primary healthcare physicians should always be aware that many patients might be present with asymptomatic cardiac arrhythmias. However, not many studies have adequately assessed them in the non-cardiac population, which calls for conducting more future investigations. In the present literature review study, we aim to discuss the indications, contraindications, and clinical significance of using the Holter monitoring device based on data from the relevant studies in the literature.
A Review of Current Clinical Concepts in the Pathophysiology, Etiology, Diagnosis, and Management of Hypercalcemia

Calcium is the most abundant extracellular cation in the body, and it is responsible for structural and enzymatic functions. Calcium homeostasis is regulated by 3 factors: calcitonin, vitamin D, and parathyroid hormone (PTH). Hypercalcemia is defined by a serum calcium concentration >10.5 mg/dL, and it is classified into mild, moderate, and severe, depending on calcium values. Most cases are caused by primary hyperparathyroidism and malignancies. Various mechanisms are involved in the pathophysiology of hypercalcemia, such as excessive PTH production, production of parathyroid hormone-related protein (PTHrp), bone metastasis, extrarenal activation of vitamin D, and ectopic PTH secretion. The initial approach is similar in most cases, but a definitive treatment depends on etiology, that is why etiological investigation is mandatory in all cases. The majority of patients are asymptomatic and diagnosed during routine exams; only a small percentage of patients present with severe manifestations which can affect neurological, muscular, gastrointestinal, renal, and cardiovascular systems. Clinical manifestations are related to calcium levels, with higher values leading to more pronounced symptoms. Critically ill patients should receive treatment as soon as diagnosis is made. Initial treatment involves vigorous intravenous hydration and drugs to reduce bone resorption such as bisphosphonates and, more recently, denosumab, in refractory cases; also, corticosteroids and calcitonin can be used in specific cases. This review aims to provide a clinical update on current concepts of the pathophysiology of calcium homeostasis, epidemiology, screening, clinical presentation, diagnosis, and management of hypercalcemia.
Stability of Cocaine, Opiates, and Metabolites in Dried Saliva Spots

Drug abuse still represents a global problem, and it is associated with an increased risk of diseases, injuries, and deaths. Cocaine (COC) and opiates are the most abused drugs and account for a significant number of fatalities. Therefore, it is important to develop methods capable of effectively identifying and quantifying these substances. The present study aims to evaluate the long-term stability of COC, ecgonine methylester (EME), benzoylecgonine (BEG), cocaethylene (COET), norcocaine (NCOC), morphine (MOR), codeine (COD) and 6-monoacetylmorphine (6-MAM) in oral fluid samples. The analytes of interest were isolated from the matrix (50 µL) using the dried saliva spots (DSS) sampling approach and were subsequently analyzed by gas chromatography coupled with tandem mass spectrometry (GC–MS/MS). The parameters that could influence the stability of the target compounds were studied, and these were storage temperature, light, use of preservatives (and respective concentrations), and time. The effects of each parameter were evaluated using the design of experiments (DOE) approach. The stability of the target analytes was improved when the DSS were stored at room temperature, in the presence of light and using 1% sodium fluoride. The best conditions were then adopted for the DSS storage and long-term stability was assessed. COD was only stable for 1 day, EME was stable for 3 days, COC, COET, NCOC and 6-MAM were stable for 7 days, MOR for 14 days and BEG remained stable throughout the study (136 days). This is the first study that evaluates the stability of these compounds in oral fluid samples after application in DSS cards, and optimizes the conditions in order to improve their stability.
Hand Gesture Recognition for 3D-Heritage-Tourism using Microsoft Kinect Sensor

Development new interaction methods between human and computer is taken most interest of researchers in human-comuter interaction realm. As well, computer with 3D applications makes the computer world more nature and realistic to users. In this paper, we present a 3D viewer application for heritage tourism, named HT3DViewer, using RGB camera and depth camera of Microsoft Kinect sensor. This application helps people to outlook the heritages through their computer in the realistic view. Also, it supports users to control the view with their hands gestures instead of using mouse or keyboard.
A Brief History of Giant Viruses’ Studies in Brazilian Biomes

Almost two decades after the isolation of the first amoebal giant viruses, indubitably the discovery of these entities has deeply affected the current scientific knowledge on the virosphere. Much has been uncovered since then: viruses can now acknowledge complex genomes and huge particle sizes, integrating remarkable evolutionary relationships that date as early as the emergence of life on the planet. This year, a decade has passed since the first studies on giant viruses in the Brazilian territory, and since then biomes of rare beauty and biodiversity (Amazon, Atlantic forest, Pantanal wetlands, Cerrado savannas) have been explored in the search for giant viruses. From those unique biomes, novel viral entities were found, revealing never before seen genomes and virion structures. To celebrate this, here we bring together the context, inspirations, and the major contributions of independent Brazilian research groups to summarize the accumulated knowledge about the diversity and the exceptionality of some of the giant viruses found in Brazil.
Wi-Fi's Promise and Broadband Divides: Reconfiguring Public Internet Access in Austin, Texas

Although the Unlicensed National Information Infrastructure (UNII) has been identified as a strategic component of policies aiming at achieving universal broadband by 2007, few studies have explored how the rollout of public wireless broadband networks are delivering the promise of high-speed services for all. Through a multi-method case study approach, this paper delves into some of these key issues by examining the process of configuration of public Wi-Fi networks in Austin, Texas. Austin is one of the most “unwired” cities in the U.S., and increasingly known as a world-class industrial center in wireless. Our assessment of Austin’s public Wi-Fi landscape reveals that the opportunities opened by the unlicensed spectrum are materializing in two different directions. On the one hand, we found evidence of proliferation of new spaces for high-speed connectivity in the city, leading to more commercial activities and innovations benefiting the local economy. On the other hand, public Wi-Fi networks are growing in an uneven fashion, further enhancing connectivity in commercial areas and more affluent areas while leaving behind the underserved population living in less affluent neighborhoods of the city. The presence of a critical mass of early adopters, strong network collaboration between private, public and non-profit organizations, and the spillover effects of Austin tech economy are identified as main factors behind the growth of public WiFi in the city. The legacy of antimunitelecom laws, the predominance of the commercial, venue-sponsored model, and the lack of clear solutions to extend connectivity in low-income areas are preventing the use of public Wi-Fi for enhancing access in poorer areas of the city.
Molecular dynamics simulations and MM-GBSA reveal novel guanosine derivatives against SARS-CoV-2 RNA dependent RNA polymerase

According to the World Health Organization (WHO), SARS-CoV-2 is responsible for more than 5 M deaths and is reported in 223 countries infecting 250+ M people. Despite the current vaccination momentum, thousands of people die every day by COVID-19. Suggesting possible blockers of the viral RNA-dependent RNA polymerase is highly needed for potential effective therapeutics against SARS-CoV-2. This study utilizes combined molecular dynamics simulation and molecular docking to test novel guanosine derivatives against SARS-CoV-2 RdRp. Results reveal the binding potency of nineteen guanosine derivatives against SARS-CoV-2 solved structures. The bulky moieties (hydroxyl or fluorated phenyl moieties) added to the 2′ position of the ribose ring positively impacted the binding affinity to RdRp. The current in silico study represents a one-step-ahead for suggesting new possible blockers of SARS-CoV-2 RdRp that are yet to be verified in the wet lab. It offers new potential binders or blockers of RdRp that bind to the protein active site tighter than remdesivir. The latter was approved by the food and drug administration (FDA) for emergency use against COVID-19 last year.
A weight of evidence approach for bioaccumulation assessment

Bioaccumulation assessments conducted by regulatory agencies worldwide use a variety of methods, types of data, metrics, and categorization criteria. Lines of evidence (LoE) for bioaccumulation assessment can include bioaccumulation metrics such as in vivo bioconcentration factor (BCF) and biomagnification factor (BMF) data measured from standardized laboratory experiments, and field (monitoring) data such as BMFs, bioaccumulation factors (BAFs), and trophic magnification factors (TMFs). In silico predictions from mass‐balance models and quantitative structure‐activity relationships (QSARs) and a combination of in vitro biotransformation rates and in vitro–in vivo extrapolation (IVIVE) models can also be used. The myriad bioaccumulation metrics and categorization criteria and underlying uncertainty in measured or modeled data can make decision‐making challenging. A weight of evidence (WoE) approach is recommended to address uncertainty. The Bioaccumulation Assessment Tool (BAT) guides a user through the process of collecting and generating various LoE required for assessing the bioaccumulation of neutral and ionizable organic chemicals in aquatic (water‐respiring) and air‐breathing organisms. The BAT includes data evaluation templates (DETs) to critically evaluate the reliability of the LoE used in the assessment. The DETs were developed from standardized testing guidance. The approach used in the BAT is consistent with OECD and SETAC WoE principles and facilitates the implementation of chemical policy objectives in chemical assessment and management. The recommended methods are also iterative and tiered, providing pragmatic methods to reduce unnecessary animal testing. General concepts of the BAT are presented and case study applications of the tool for hexachlorobenzene (HCB) and β‐hexachlorocyclohexane (β‐HCH) are demonstrated. The BAT provides a consistent and transparent WoE framework to address uncertainty in bioaccumulation assessment and is envisaged to evolve with scientific and regulatory developments. Integr Environ Assess Manag 2023;19:1235–1253. © 2022 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Is there any difference in hearing function between surgical and natural menopause?

ABSTRACT This study was designed to examine cochlear function in surgical postmenopausal women and natural menopause. Three groups, each including 20 patients, were formed: surgical menopause (SM), natural menopause (NM), and healthy controls who had not yet gone through menopause. Conventional audiometry (0.125–8 kHz), ultra-high frequency audiometry (10–16 kHz), and otoacoustic emission (OAE) tests were used in the evaluation of the patients. Almost all the hearing thresholds were significantly poorer in the menopause groups than in the control group (p < .05). However, the amplitudes of the healthy controls were higher in transient evoked otoacoustic emissions (TEOAEs), especially in many frequencies of distortion product otoacoustic emissions (DPOAEs) (p < .05). In the SM group, all the frequencies between 0.125 and 10 kHz for the right ear, and 1, 2, 6 and 8 kHz air-conduction hearing thresholds for the left ear were significantly poorer compared to the NM group (p < .05). There was also a significant decrease in the 4, 6, and 8 kHz DPOAE amplitudes of the SM group compared to the NM group (p < .05). This study showed that postmenopausal women, in particular those with SM had significantly poorer hearing thresholds and lower OAE amplitudes. Menopause may be a potential risk factor for the development of hearing loss in women.
Reliability of a 4-Story Steel Moment-Resisting Frame Against Collapse Due to Seismic Excitations

This paper illustrates a process for estimating the uncertainty in estimation of collapse capacity of buildings in seismic excitation using Monte Carlo simulation and FOSM method. The structure used in this study is a 4-story steel moment-resisting frame designed based on current seismic provisions whose collapse prediction has been validated through a collapse test of a 1:8 scale model structure at the University of Buffalo's NEES Equipment Site. It is shown that the uncertainty in estimation of collapse capacity due to uncertainty in estimation of deformation parameters of beams and columns that control component nonlinear behavior is moderately dependent on the correlation between these parameters. For the 4-story steel moment-resisting frame used in this study the uncertainty in estimation of collapse capacity due to component modeling uncertainties varies between 0.25 and 0.35 for correlation between these parameters ranging from 0.3 to 1.0. This is due to the fact that for the 4–story structure, the P-Δ effect is the major reason for collapse rather than building component deterioration. Results of this research show that the probability of collapse for the 4–story structure at the 2/50 hazard level can increase from 3% to 18% once a confidence of 90% is sought for the collapse probability.
Discussion on the Monitoring Method of Toxic and Harmful Gas in Operation Place

Monitoring the toxicand harmful gas in productive process has along history in our country,In the past,due to the economic condition and technical condition,the monitoring of gas are all for security consideration.This paper introduces the composition and harm of toxic and harmful gas in coal deep processing and painting operation place,introduces the monitoring method of toxic and harmful gas,and puts forward how to select corresonding monitoring method.
SCREENING OF THREE VARIETIES OF PEPPER (CAPSICUM SPP) IN DELTA STATE POLYTECHNIC, OZORO NIGERIA

This project work took place at school of agriculture teaching and research farm in Delta State Polytechnic Ozoro. Ozoro is located in Isoko North local government Area of Delta State. There are different varieties of pepper in Ozoro the need to screen the yield of three varieties of pepper becomes necessary. Three varieties of pepper seeds were bought from the market and were nursed for about 3 weeks before they were transplanted into the main field at a spacing of 60cm x 60cm and planting depth of 5cm. the seedling were replicated four times, in a randomize complete block design. The parameters measured are member of leaves, plant height number of branches and number of fruits at hearvest. These were taken at the interval of two weeks. Data collected were subjected to analysis of variance (ANOVA). Table 1: reveals the number of leaves of three varieties of pepper. The result shows that mexi-bell hot pepper had the highest number of leaves of 17.5, 60.25 and 63.0 as against 16.75, 31.25,33.0 and 16.25, 58.35 and 60.0 for sweet bell pepper and serano hot pepper respectively. Table (2) shows the plant height (cm) of three varieties of pepper that is planted, mexi-bell hot pepper had a plant height of 8.5, 20.5 and 23 as against 6.75, 16.78, 18 and 5.77, 16.75 and 20.25 for serano hot pepper and sweet bell pepper. Table (3) shows the number of branches of three varieties of pepper. The result shows that mexi-bell hot pepper had more or highest number of branches of 3,6.5, 8 and 2.5, 4.75 and 6.25 for serano
Numerical Simulation Method and Dynamic Response of Ship-bridge Collision

Designing bridge′s anti-collision structure needs the dynamic response towards collision and exact collision force.In this paper,a discrete pier model and a 3000 DWT cargo ship model are established by LS-DYNA to simulate ship-bridge collision process.For considering water influence in the impact process,no-water model,additional mass model,and fluid-structure coupling model are used to compare and analyze water′s impact on the dynamic response of the pier and ship.The results show that the collision force of different models is very close to each other,and water makes little difference on the collision force;the pier′s horizontal displacement happens 0.2sbehind the pile cap′s,and the horizontal displacements of the pier and the pile cap in the additional mass calculation model are slightly larger than those of the other two models;the results of the additional mass model and the structure-fluid coupling model are very similar,while the additional mass model is much more efficient in calculating,and its computation time is only 2/5of the structure-fluid coupling model′s.
An Assessment of Knowledge, Attitude and Practices (KAP) towards Diabetes and Diabetic Retinopathy

Introduction: Diabetes mellitus is an endocrine metabolic disorder whereas Diabetic retinopathy is a major complication of diabetes. Diabetes occurs due to defect in insulin secretion, action, or both which in turn leads to chronic hyperglycemia with disturbances of carbohydrate, fat, and protein metabolism and is associated with long-term damage, dysfunction, and failure of different organs (eyes, kidneys, nerves, heart, and blood vessels). DR is a progressive alteration in the microvasculature that lead to retinal ischemia, altered retinal permeability, neovascularisation, macular edema. Methods and Materials: It was a prospective cross-sectional study, which was carried out over a period of 6 months (December-2020 to May-2021). The knowledge, attitude and practice were assessed in diabetic patients on diabetes and diabetic retinopathy by using questionnaires. A total of 362 diabetic patients are included in this study. The completed questionnaires were collected and analysed using SPSS software (version 19) and results were expressed in percentages. Results and Discussion: In the study, majority of the patient were male and in the age group of 46-55 years. Patients had good knowledge on diabetes when compared to diabetic retinopathy, positive attitude was seen towards diabetes than diabetic retinopathy and good practice patterns were observed in diabetes retinopathy than diabetes. Conclusion: Our study concluded that the patients had good knowledge on about diabetes and a very poor knowledge on diabetic retinopathy. Positive attitude was seen in diabetes than diabetic retinopathy where as good practice patterns was seen in diabetic retinopathy than diabetes patients.
Valores emancipatórios, personalidade e a pandemia de covid-19

O artigo analisa os impactos da pandemia de covid-19 sobre as prioridades valorativas individuais e societais dos brasileiros. Analisamos também, com base na Big Five Theory, como as diferenças individuais em termos de personalidade desempenham papel importante na forma como as pessoas lidam com mudanças. Os resultados indicam que a situação de pandemia não provocou alterações substanciais nos valores emancipatórios dos brasileiros. Além disso, veri ca-se que o apoio a tais valores é determinado sobretudo pela posse de recursos como escolarização e renda, mas também é impactado por aspectos relacionados aos traços de personalidade.
EFFICACY EVALUATION OF THE ASSOCIATION OF SOME VEGETAL EXTRACTS IN PATIENTS SUFFERING FROM TRAUMATIC BRAIN INJURY. PILOT STUDY (II)

The aim of the current study was to evaluate the effects of health supplements as add-on treatment in patients suffering from cranio-cerebral trauma. During the entire monitoring period (21 days), several serum biomarkers were determined: sodium, potassium, haemoglobin, leukocytes, lymphocytes, urea, creatinine, C-reactive protein, as well as a continuous response variable: Glasgow Coma Scale. The clinical results indicated an improvement in terms of Glasgow Coma Scale compared to the control group.