Miracle-dz/UniFAR-FTUs huggingface dataset:
EVALUATION OF CLINICAL AND RADIOLOGICAL RESULTS OF HYBRID TOTAL HIP REPLACEMENT (THR) IN VARIOUS DISORDERS

Background: The human hip joint is extremely complex as the consequence of the functional demands on it by the body. Because of its complex biomechanics and important function, a stable painless hip is required for normal locomotion for which Total Hip Replacement is one of the most advanced method. Objectives: To evaluate the clinical, functional, and radiological results of acetabular non-cemented and femoral cemented (hybrid) total hip replacement in various disorders of hip. Materials and Methods: This hospital based prospective observational study was conducted among18 patients between April 2012 and June 2013 for various disorders of hip in the Department of Orthopaedics, Batra hospital and Medical Research Centre, New Delhi. Results: Mean Harris hip score improved significantly (p=0.0001) post-operatively (88.00 ± 8.78) as compared to pre-operative score (34.00 ± 11.12). Pain, limp, walking distance & deformity significantly improved with (hybrid) total hip replacement. Conclusion: This study provides evidence of excellent modality of treatment for various disorders of hip.
Time domain modeling and simulation of Direct Current Solid-State Transformer

Direct Current Solid-State Transformer (DCSST) as the core device of solid-state transformers(SST), can realize the function of voltage conversion and energy transfer, has many advantages. Therefore, this paper carried out the fine modeling work of DCSST, established the MOSFET high-precision physical level switch model and DCSST circuit model through the discrete time domain modeling method, and carried out the Norton equivalent of a single MOSFET, thereby reducing the simulation order and improving the simulation efficiency.
ASSESSMENT OF THE PROGNOSTIC VALUE OF IMMATURE PLATELET FRACTION IN ST ELEVATION MYOCARDIAL INFARCTION

Background: The immature platelet fraction is a valuable indicator for determining the underlying cause of low platelet counts. The study aimed to evaluate the predictive value of immature platelet fraction (IPF) estimation to further stratifies patients with ST Elevation Myocardial Infarction (STEMI) according to their risk for clinical outcomes. Materials and Methods: This prospective cohort study was conducted at Govt. Stanley Medical College and Hospital, Chennai, from October 2015 to March 2016, on 100 patients admitted with STEMI in the ICCU. A patient's history includes age, sex, symptoms, risk factors, family history of CAD, and other illnesses. Assessments include vital signs, hemodynamic status, heart failure features, and complications. Blood tests, lipid profiles, and anti-HCV and HIV serology are performed. Results: Patients who did not survive had a significantly higher mean immature platelet fraction (IPF) value compared to those who survived (4.8% vs. 2.65%, P<0.0003). Those with failed thrombolysis had a higher mean IPF (4.18%) than those with successful thrombolysis (1.75%). Increasing Killip class was associated with higher mean IPF (1.7%, 3.2%, 4.6%, and 6.1% for classes I to IV). Moderate to severe LV systolic dysfunction was more prevalent in patients with higher IPF values. Major adverse cardiac events (MACE) increased from 5% in the low IPF tertile to 100% in the high IPF tertile. A significant difference in MACE, mortality, ST resolution, Killip, EF, and TIMI scores between IPF. Conclusion: Higher immature platelet fraction is closely associated with risk factors like LV systolic dysfunction, TIMI score and Killip class in STEMI patients.
Ant Colony Algorithm Optimization for Software Defined Network Load Balancing

To solve the problems of low efficiency and poor flexibility caused by the traditional load balancing methods which can not obtain the statistical data of network devices effectively or the load balancing influence factors, this paper proposes a joint path server ant colony optimization algorithm considering path level and server level jointly. The server balance module collects the performance index of the server, grasps the status of the server in time, and calculates the weight of the server by using the dynamic algorithm based on the server performance. In the process of rerouting, this paper adopts an optimized ACO algorithm, which changes the search rules of the ordinary algorithm. The path searched by ants is filtered by the dynamic load balance value to determine the optimal path. The simulation results show that compared with the traditional load balancing control algorithm, the proposed scheme has better quality of service. It can achieve greater throughput and lower packet loss rate, which also shows excellent management and utilization of network resources.
Upper‐Mantle Anisotropy in the Southeastern Margin of Tibetan Plateau Revealed by Fullwave SKS Splitting Intensity Tomography

The southeastern margin of the Tibetan Plateau has undergone complex deformation since the Cenozoic, resulting in a high level of seismicity and seismic hazard. Knowledge about the seismic anisotropy provides important insight about the deformation mechanism and the regional seismotectonics beneath this tectonically active region. In this study, we conduct fullwave multi‐scale tomography to investigate the seismic anisotropy in the southeastern margin of the Tibetan Plateau. Broadband records at 111 permanent stations in the region from 470 teleseismic events are used to obtain 5,216 high‐quality SKS splitting intensity (SI) measurements, which are then inverted in conjunction with 3D sensitivity kernels to obtain an anisotropic model with multi‐scale resolution. Resolution tests show that our data set recovers anisotropy anomalies reasonably well on the scale of 1° × 1° horizontally and ∼100 km vertically. Our result suggests that in the southeastern margin of the Tibetan Plateau the deformation in the lithosphere and asthenosphere are decoupled. The anisotropy in the lithosphere varies both laterally and vertically as a result of dynamic interactions of neighboring blocks as well as lithospheric reactivation. The anisotropy in the asthenosphere largely follows the direction of regional absolute plate motion. The SKS splittings observed at the surface are shown to be consistent with the vertical integral of our depth‐dependent anisotropy model over lithospheric and asthenospheric depths.
A PROSPECTIVE STUDY OF THE FUNCTIONAL OUTCOME OF OPEN REDUCTION AND INTERNAL FIXATION IN LISFRANC FRACTURE DISLOCATION

Background: Lisfranc injuries are fracture–dislocations of the tarsometatarsal joint complex. The study was aimed to determine the functional outcome of tarsometatarsal joint fracture-dislocation and to evaluate the incidence of complications in these fracture dislocation as a result of open reduction and internal fixation. Materials and Methods: The Department of Orthopaedics at the Government Medical College in Thiruvananthapuram conducted the prospective study. The study population consists of all patients with lisfranc fracture dislocation admitted to the study setting between February 2014 and January 2016. The sample size was determined to be 45 using a consecutive sampling technique. X-ray was examined during the follow-up period and functional evaluation was carried out by American Orthopaedic Foot and Ankle Society (AOFAS) midfoot score system. Analysis of variance was used to test the different types of Myerson classification. Result: All patients were followed up for a minimum period of 6 months(6 months – 12 months). 55.6% of patients had only isolated lisfranc injury, others had associated other long bone fractures or spinal/pelvic injuries. 80% of study subjects underwent surgery within the first 24 hours. 71.1% of study subjects were free of any specific complications associated with lisfranc injury or its surgical management. Rest of the patients had infection, compartment syndrome or hardware failure. Average AOFAS score of cases with pain score less than 3 was 77.67±3.7 and that of the cases with pain score greater than 8 was 58±1. There was statistically significant relationship between complications and AOFAS score. Conclusion: Poor results in the functional outcome and health related quality of life measurements were due to occurrence of complications, inability to pursue their original occupations and the perception of ‘being
Effects of uncertainty in major input variables on simulated functional soil behaviour

Uncertainties in major input variables in water and solute models were quantified and their effects on simulated functional aspects of soil behaviour were studied using basic soil properties from an important soil map unit in the Netherlands. Two sources of uncertainty were studied: spatial variability of basic soil properties, and the use of pedotransfer functions to predict soil hydraulic functions. Depending on the type of process studied, variability of basic soil properties explained between 40 and 99.9% of the total variance. Uncertainty of pedotransfer functions is of importance mainly when physical soil behaviour (e.g. workable days and aeration status) is studied.
Japan’s economic success: can the west benefit from the Japanese example

The astounding success of the Japanese economy has in the past decade or so been believed by many to provide an answer to the West's relative economic decline. This thesis attempts to provide a more complete account of the factors involved in the Japanese success than that which is generally found in the literature on the subject; the purpose of this is to suggest that the transference of only one success factor or element of the Japanese system may not be the simple solution to Western problems as is so often assumed. It begins with a chapter on Japanese economic development for background. Chapters 3 and 4 respectively cover corporate culture and the management practices considered unique to Japan. These two areas have received the most attention in the literature on how the West can benefit from the Japanese example, the assumptions being that if these are transferred to or copied by the West, than an economic turnaround would ensue. For balance, the next chapter discusses the concomitants of these management practices which may be considered negative by the West. It continues with an examination of Japanese subsidiaries in the United States and Great Britain and then presents the theories of whether or not the system is in actuality transferable to the West by Western managers. The last chapter presents other factors in Japan’s economic success in order to argue that the 'popular' assumptions may be too simplistic to provide the resultant success expected.
Towards learning quasi-static models of markerless deformable linear objects for bimanual robotic manipulation

In everyday life, people encounter and skillfully manipulate Defromable Linear Objects (DLOs), such as cables, ropes, threads, strings, and hoses. It would be beneficial to give robots similar skills to enable them to perform surgical suturing [1], knot tying [2], wiring harness assembly in the automotive sector [3], or threading the lace through the narrow hole [4]. A typical approach to manipulate DLOs is to use their models to plan the motion and control commands necessary to rearrange it to the desired state. In recent years, there were many attempts to develop DLO models, such as FEM-based ones [5], [6], using Cosserat rod theory [7] or dynamic B-splines [8]. However, these models make strong assumptions about the properties of the objects or require significant amounts of computations to evaluate. A response to these problems was the trial to develop a neural network-based model [9], which can mimic the behavior of a particular DLO with one end rigidly attached, based on the careful measurements of the cubic markers located along the DLO, which seems rather an unrealistic scenario in the typical problems of DLO manipulation. In this paper, we present a neural network-based approach to develop a quasi-static model of the real DLO being manipulated by a pair of robots without the use of any markers (see Figure 1). DLO shape is being tracked with an RGBD camera, and the upgraded approach proposed in [10]. Based on these measurements, we learn a machine learning model able to predict the state of a DLO, given an actual DLO state and an initial and final pose of the end-effectors (EEs) holding the DLO. Our main contribution is the first data-driven 3D model of a DLO, that can be used without any markers on featureless DLOs. Our proposed model works in a partially observable setting, as it is impossible to directly detect the bend and twist of the raw DLO using just RGBD data, and shows the ability to accurately predict the behavior of the DLO. We evaluate a neural model of a DLO proposed in [9] (INBiLSTM), a simple fully connected architecture (FC), and analyze the impact of different data representations on the model’s accuracy. We introduce a simple but effective data augmentation procedure that significantly improves the
[How frequent are diabetes-related amputations of the lower limbs in Germany? An analysis on the basis of routine data].

BACKGROUND AND OBJECTIVE The total number of lower limb amputations in Germany as well as the frequency of lower limb amputations attributable to diabetes is unknown. Currently available estimates are based on regional studies resulting in different totals. The aim of this study was to perform a census of all lower limb amputations in Germany in order to obtain valid estimates of the number of amputations attributable to diabetes mellitus in Germany. PATIENTS AND METHODS Hospital performance and expenditure statistics were used to obtain a comprehensive count of lower limb amputations. The number of amputations in diabetic patients as well as the number of diabetes-related amputations were assessed by calculating the proportion of diabetes among amputees as well as attributable amputations standardized to the age and gender distribution in Germany in 2001, using routine data from the Local Health Insurance Funds (AOK) as well as previous analyses from Germany. RESULTS In 2001, 43,544 lower limb amputations and additional 3,981 revisions of amputations were performed in Germany. Among these almost 29,000 lower limb amputations were estimated to be performed in diabetic patients. More than 26,000 lower limb amputations per year were estimated to have been attributable to pre-existing diabetes mellitus. CONCLUSIONS Lower limb amputations as a complication of diabetes mellitus are more frequent in Germany than previously estimated. Intensified prevention and therapy--as intended in disease management programs--are urgently needed to decrease the complications of diabetes and ultimately to reduce diabetes mellitus-related costs.
EVALUATION OF POST OPERATIVE ANALGESIC EFFECTS OF INTRAPERITONEAL INSTILLATION OF BUPIVACAINE WITH MORPHINE VERSUS BUPIVACAINE WITH BUPRENORPHINE FOR LAPAROSCOPIC CHOLECYSTECTOMY : A DOUBLE BLIND COMPARATIVE STUDY

Background: Local anaesthetic instillation along with opioid into the peritoneum has good outcome in terms of relieving pain in post operative period after Laparoscopic cholecystectomy. Aims and Objectives: To assess ,compare and evaluate post operative analgesic effects of intraperitoneal instillation of 25ml 0.25%Bupivacaine and 2mg Morphine versus 25ml 0.25%Bupivacaine and 0.3mg Buprenorphine to provide effective post operative pain relief in patients undergoing Laparoscopic cholecystectomy under general anaesthesia. Study design: This was a prospective, randomized, double-blind study. Materials and Methods: After obtaining ethical committee's clearance and informed consent, sixty patients, aged between 18-60 years, of either gender belonging to American Society of Anesthesiologists physical status I & II scheduled for Laparoscopic cholecystectomy were included and categorized into two groups (n = 30). Group BM received 25 mL 0.25% Bupivacaine+2mg Morphine diluted with 0.8ml saline and Group BB received 25mL of 0.25% Bupivacaine+0.3mg Buprenorphine intraperitoneally after surgery. Total volume of 26ml anaesthetic solution was used in both groups. Statistical analysis: The data were analyzed using paired t-test. The results were analyzed and compared to previous studies. SPSS software version 22 was used. Results: Buprenorphine and Morphine along with Bupivacaine prolonged the duration of post-operative analgesia . Haemodynamic stability and side effects with both opioids were statistically insignificant . The VAS score is less in group BB as compared to group BM and was statistically significant(p<0.05) at 30min, 1hr, 2hr, 4hr, 8hr, 12hr i.e 0,1,1,1,1,2. Conclusion: Buprenorphine and Morphine were found to be safe adjuvants but the analgesic requirements in patients undergoing laparoscopic cholecystectomy was less when Buprenorphine with Bupivacaine was instilled intraperitoneally as compared to patients who recieved Morphine with Bupivacaine.
Interval versus Continuous High-Intensity Exercise in Chronic Obstructive Pulmonary Disease

Both groups experienced large improvements in health-related quality of life (increase of CRQ total scores of 1.00 [SD,0.98] for the interval exercise group and 1.02 [SD, 1.05] for thecontinuous exercise group). Adjusted between-group differencesbetween the interval exercise group and the continuous exercisegroup (–0.05 [95% CI, –0.42 to –0.32] for CRQ and 1.1 meters[CI, –25.4 to 27.6 meters] for 6-minute walking distance) werewithin the a priori defined boundaries of noninferiority (0.5 forCRQ and 45 meters for 6-minute walking distance). Twenty-one(47.9%) patients using interval exercise and 11 (24.0%) patientsusing continuous exercise were able to adhere to the protocol(difference, 23.9 percentage points [CI, 5.0 to 42.8 percentagepoints];
MQTransformer: Multi-Horizon Forecasts with Context Dependent Attention and Optimal Bregman Volatility

In many forecasting applications (e.g. retail demand, electricity load, weather, finance, etc.), the forecasts must obey certain properties such as having certain context-dependent and time-varying seasonality patterns and avoiding excessive revision as new information becomes available. Here we propose a new forecasting neural net architecture that addresses some of these issues, MQ-Transformer, by incorporating three architectural improvements to the current state-of-the-art: 1) a novel decoder-encoder attention that aligns the historical and future time periods 2) a novel positional encoding that learns seasonality from the historical time series and 3) a novel decoder-self attention that allows the network to minimize the forecast volatility. We then define a new measure of forecast volatility, Bregman Volatility, to understand one major source of the improvement from our model. Bregman Volatility allows us to compute the optimal volatility of a sequence of forecasts in terms of the improvement in forecast accuracy over that time period. We show both theoretically and empirically that the decoder-self attention module optimizes Bregman volatility and thereby improves forecast accuracy as well.
Endovascular Procedures for Intracranial Arterial Disease ( Atherosclerosis and Aneurysms ) Endovascular Procedures for Intracranial Arterial Disease ( Atherosclerosis and Aneurysms ) Description

The policies contained in the FEP Medical Policy Manual are developed to assist in administering contractual benefits and do not constitute medical advice. They are not intended to replace or substitute for the independent medical judgment of a practitioner or other health care professional in the treatment of an individual member. The Blue Cross and Blue Shield Association does not intend by the FEP Medical Policy Manual, or by any particular medical policy, to recommend, advocate, encourage or discourage any particular medical technologies. Medical decisions relative to medical technologies are to be made strictly by members/patients in consultation with their health care providers. The conclusion that a particular service or supply is medically necessary does not constitute a representation or warranty that the Blue Cross and Blue Shield Service Benefit Plan covers (or pays for) this service or supply for a particular member. FEP 2.01. 54 Endovascular Procedures for Intracranial Arterial Disease (Atherosclerosis and Aneurysms)
Activation of Pannexin-1 Hemichannels Augments Aberrant Bursting in the Hippocampus

Pannexin-1 (Px1) is expressed at postsynaptic sites in pyramidal neurons, suggesting that these hemichannels contribute to dendritic signals associated with synaptic function. We found that, in pyramidal neurons, N-methyl-d-aspartate receptor (NMDAR) activation induced a secondary prolonged current and dye flux that were blocked with a specific inhibitory peptide against Px1 hemichannels; knockdown of Px1 by RNA interference blocked the current in cultured neurons. Enhancing endogenous NMDAR activation in brain slices by removing external magnesium ions (Mg2+) triggered epileptiform activity, which had decreased spike amplitude and prolonged interburst interval during application of the Px1 hemichannel blocking peptide. We conclude that Px1 hemichannel opening is triggered by NMDAR stimulation and can contribute to epileptiform seizure activity.
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response

In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-regulated expression of the vitamin D receptor and the vitamin D-1–hydroxylase genes, leading to induction of the antimicrobial peptide cathelicidin and killing of intracellular Mycobacterium tuberculosis. We also observed that sera from African-American individuals, known to have increased susceptibility to tuberculosis, had low 25-hydroxyvitamin D and were inefficient in supporting cathelicidin messenger RNA induction. These data support a link between TLRs and vitamin D–mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection.
DETECTION OF HEART BEAT SOUND CONDITIONS USING LSTM AND MFCC

-In this paper, we present a method for heart sound classification using long short-term memory (LSTM) and Mel Frequency Cepstral Coefficients (MFCC). The proposed method uses MFCC to extract features from heart sounds and LSTM to classify heart sounds into normal and abnormal classes. The dataset used in this study consists of heart sound recordings from different clinical settings, and the proposed method achieved an accuracy of 92% on this dataset
Title : Intravenous Antibiotic Therapy and Associated Diagnostic Testing for Lyme Disease Professional Institutional

Professional Institutional Original Effective Date: April 4, 2011 Original Effective Date: May 4, 2011 Revision Date(s): April 12, 2012; December 7, 2012; February 28, 2014; February 1, 2017; April 11, 2018; November 20, 2018 Revision Date(s): April 12, 2012; December 7, 2012; February 28, 2014; February 1, 2017; April 11, 2018; November 20, 2018 Current Effective Date: February 1, 2017 Current Effective Date: February 1, 2017
Intravenous Antibiotic Therapy and Associated Diagnostic Testing for Lyme Disease Policy

When Policy Topic is covered Treatment of Lyme disease consists of oral antibiotics, except for the following indications: I. A 2to 4-week course of IV antibiotic therapy may be considered medically necessary in patients with neuroborreliosis with objective neurologic complications of documented Lyme disease (see the following for methods of documentation). Objective neurologic findings include:  Lymphocytic meningitis with documented cerebrospinal fluid (CSF) abnormalities  Cranial neuropathy, other than uncomplicated cranial nerve palsy, with documented CSF abnormalities  Encephalitis or encephalomyelitis with documented CSF abnormalities  Radiculopathy  Polyneuropathy.