Miracle-dz/UniFAR-FTUs huggingface dataset:
Robotic telescopes on the Antarctic plateau

The high plateau that covers half of the continent of Antarctica contains the best astronomical observing sites on Earth. The infrared sky background is low, the precipitable water vapour is low, the sub-millimetre sky opacity is low, the winds are low, the atmosphere is exceedingly clear and stable, it never rains, there is no dust, it is geological stable, and the seeing at some sites, notably Dome C, is superb. The turbulence prole in the atmosphere is benecial for adaptive optics, with fewer actuators and fewer deformable mirrors being required, and with signicant correction being possible at visible wavelengths. For projects that require continuous monitoring, e.g., planet detection through micro-lensing, a single robotic telescope in Antarctica can replace a network of 4n6 telescopes placed around the world at mid-latitude sites. For many projects requiring large apertures, a given size telescope in Antarctica will outperform a telescope of 2n3 times the aperture at a mid-latitude site. We review what is known about the site conditions, and outline some of the issues involved with designing robotic telescopes to work in Antarctica.
Direct transfer for thrombectomy in patients with large vessel occlusions on computed tomography angiography results in safe revascularization

INTRODUCTION: Endovascular mechanical thrombectomy (EVT) has become the standard of care treatment for both intravenous tissue plasminogen activator eligible and ineligible patients presenting with an acute ischemic stroke due to a large vessel occlusion (LVO) within 24 h. Due to limited access to EVT, patients typically present to a non-EVT-capable center and are transferred to a larger, EVT-capable center. Quality improvement work has focused on improving this process to shorten the time to definitive recanalization of the affected vessel. MATERIALS AND METHODS: We retrospectively reviewed 98 consecutive patients who were transferred from an outside institution to our Comprehensive Stroke Center from July 2019 to September 2021. Thirty-nine of these patients had a diagnosed LVO at the transferring center on computed tomography angiography and were transferred directly to the angiography suite (DAT) whereas 59 patients were transferred to our Emergency Department for further imaging (EDT). Three of the patients in the DAT group did not undergo thrombectomy as there was no LVO identified on catheter angiography and were excluded from the study. RESULTS: Demographic and medical comorbidities were similar between the two groups. The DAT group had more severe strokes on presentation compared to the EDT group as measured by the National Institute of Health Stroke Severity (17.5 vs. 15, P = 0.048). Last known well (LKW) to arrival time in the angiography suite was significantly shorter in the DAT group (280 min vs. 474 min, P = 0.002). Patients in the DAT group were revascularized faster than the EDT group relative to LKW (320 min vs. 534 min, P < 0.001) while door-to-groin puncture and door-to-revascularization rates were similar. Modified Rankin score, incidence of symptomatic intracranial hemorrhage, and need for decompressive hemicraniectomy were similar between the two groups. Successful revascularization as measured by thrombolysis in cerebral infarction score occurred at a higher rate in the DAT group but was not statistical significance (97% vs. 85%, P = 0.055). DISCUSSION/CONCLUSION: DAT resulted in safe EVT compared to EDT with significant improvement in LKW to angiography suite presentation and subsequent vessel recanalization. Patients who underwent DAT experienced similar functional outcomes compared to EDT despite experiencing more severe strokes.
Transient Response of ENSO-Monsoon Teleconnection in MRI-CGCM2.2 Climate Change Simulations

This study investigates the impact of anthropogenic climate change on the Indian summer monsoon, and the ENSO-monsoon teleconnection, using the transient climate change simulations of the MRI coupled model (MRI-CGCM2.2). In the present simulations atmospheric greenhouse gas (GHG) concentrations and aerosols are varied to represent observed changes during 1850–2000, and from 2001–2100, at the rate prescribed by the SRES-A2 and B2 scenarios to study the response of the monsoon climate during 2071–2100. All India annual temperature shows warming by 2.35 � C (1.64 � C), while all-India monsoon rainfall (JJAS) indicates an increase by 9% (6%) in SRES-A2 (B2) scenario relative to the present climate (1971–2000). Increase in the monsoon precipitation is evident over parts of south India, parts of the Bay of Bengal and northwest India. The simulations feature stronger warming over South Asia relative to the Indian Ocean, leading to enhanced land-sea temperature contrast. Enhanced moisture in a warmer scenario, coupled with enhanced monsoon circulation, leads to enhanced moisture transport over the Indian region from both the Bay of Bengal and Arabian Sea leading to increased monsoon precipitation. Decomposition of the moisture transport into divergent and non-divergent components shows that the enhanced monsoon rainfall is mainly due to intensification in the non-divergent component of the moisture transport. While strong and continued increase in monsoon rainfall suggests
Profile of 10,935 elderly patients attending the geriatrics department of a medical college: A retrospective study from South India

Introduction: Globally, the elderly population is growing at a rate of 2.6% per year. Understanding the health profile and healthcare needs of the elderly is important. The elderly is the most vulnerable and high-risk groups in terms of health status. Their healthcare-seeking behaviour is crucial in any society. There is a need to generate awareness among the public, politicians, and policymakers regarding multiple issues related to the ageing population in the country. Objective: To know the health profile and health-related problems of geriatric patients visiting the department of geriatrics at a medical college. Methodology: A five-year retrospective analysis of medical records of patients visiting the department of geriatrics from 4 September 2016 to 4 September 2021 was done using Microsoft Excel software and IBM SPSS Statistics. All records in that duration were reviewed and included. Results: Descriptive statistics of medical and dental problems of geriatric patients were recorded. The association of medical and dental problems with gender was assessed. Conclusion: A majority of geriatricians are unaware of oral health problems. Medical–dental collaboration is inadequate and should be improved in geriatrics.
A 3-D stall-delay model for horizontal axis wind turbine performance prediction

Most design and analysis methods widely used for horizontal axis wind turbine performance prediction, such as the PROP code, are based on the traditional 2-D blade element/momentum theory (BEMT) methods, which are inadequate and underpredict the wind turbine rotor power output in the high-wind/peak-power condition, owing to effects of rotation on the wind turbine blade boundary layer. Although the deficiencies of the methods have been known for some time, this area has been neglected. The continued development of viable and well-established stall-regulated wind-turbine technology makes this research topic timely and particularly relevant to reducing the cost of wind energy. The main aim of the present paper is to describe and analyze the fundamental flow phenomena that characterize the boundary layer on rotating blades, and to develop a preliminary stall-delay model that modifies the 2-D airfoil data so as to simulate the 3-D stall-delay effects. The following steps were taken in the development of the model: 1) analysis of the 3-D integral boundarylayer equations for a reference system rotating with the blade, 2) description of the effects of rotor rotation on the separation point and its causes, and 3) determination of a simple correction formula to obtain rotating rotor lift coefficient Ci(a) and drag coefficient Cd(a) data from measured 2-D airfoil data. The preliminary 3-D stall-delay model consists of two key parameters (the ratio of local chord to local radius c/r the ratio of rotation speed to freestream velocity A) and three empirical correction factors Copyright © 1998 by the American Institute of Aeronautics and Astronautics, Inc. and the American Society of Mechanical Engineering. All rights reserved. ^Visiting Scholar. 'Assistant Professor, Senior Member AIAA. (a, b, d}. The stall-delay model is consistent with the blade element/momentum theory method and the Viterna/Tangler model, and the 3-D stall-delay model can be incorporated into the state of the art performance prediction codes, such as PROP. Through comparison with the field test data, the new model for 3-D stall-delay shows good agreement between predictions and experiments. The new model should be of great use in existing codes for horizontal axis wind turbine design and analysis.
Data processing pipeline for cardiogenic shock prediction using machine learning

Introduction Recent advances in machine learning provide new possibilities to process and analyse observational patient data to predict patient outcomes. In this paper, we introduce a data processing pipeline for cardiogenic shock (CS) prediction from the MIMIC III database of intensive cardiac care unit patients with acute coronary syndrome. The ability to identify high-risk patients could possibly allow taking pre-emptive measures and thus prevent the development of CS. Methods We mainly focus on techniques for the imputation of missing data by generating a pipeline for imputation and comparing the performance of various multivariate imputation algorithms, including k-nearest neighbours, two singular value decomposition (SVD)—based methods, and Multiple Imputation by Chained Equations. After imputation, we select the final subjects and variables from the imputed dataset and showcase the performance of the gradient-boosted framework that uses a tree-based classifier for cardiogenic shock prediction. Results We achieved good classification performance thanks to data cleaning and imputation (cross-validated mean area under the curve 0.805) without hyperparameter optimization. Conclusion We believe our pre-processing pipeline would prove helpful also for other classification and regression experiments.
Processes and products of readers’ journeys to narrative worlds

ABSTRACT In this article, I use the metaphor that readers journey to narrative worlds to review research that has spanned my career. In the first section, I consider the processes that enable readers to undertake these journeys as well as the processes that allow them to participate in the narrative worlds once they have arrived. In the second section, I review research that supports claims that readers’ journeys to narrative worlds create distance from their worlds of origin. In the final section, I consider research that documents fundamental ways in which readers’ real-world beliefs, attitudes, and behaviors are changed by their experiences of narrative worlds.
Profiling Mycobacterium ulcerans: sporulation, survival strategy and response to environmental factors

Mycobacterium ulcerans is the causative agent of Buruli ulcer – a necrotizing skin infection. As an environmental pathogen, it has developed stress response mechanisms for survival. Similar to endospore formation in M. marinum, it is likely that M. ulcerans employs sporulation mechanisms for its survival and transmission. In this review, we modeled possible transmission routes and patterns of M. ulcerans from the environment to its host. We provided insights into the evolution of M. ulcerans and its genomic profiles. We discuss reservoirs of M. ulcerans as an environmental pathogen and its environmental survival. We comprehensively discuss sporulation as a possible stress response mechanism and modelled endospore formation in M. ulcerans. At last, we highlighted sporulation associated markers, which upon expression trigger endospore formation.
HUG Initiative: Overcoming roadblocks on a research career roadmap of individuals from historically marginalized or underrepresented genders

The underrepresentation of students of Historically marginalized or Underrepresented Genders (HUGs) in STEM departments results in the low representation of HUG researchers in the space science community. This paper reviews relevant literature to explore the potential barriers that prevent HUG students from staying in STEM fields, including few opportunities to develop STEM identities, experiences with professional devaluation, and chilly campus climates. Thus, HUG students are more likely to feel excluded in STEM programs. To address the disparities, our HUG Initiative, a student-led research initiative, is proposed and piloted at a large research institution. This initiative promotes the pursuit of research careers among students who self-identify as HUG in the department of electrical and computer engineering. By holding panel discussions, interactive workshops, and networking luncheons, HUG Initiative aims to demystify what it means to be a researcher and provide resources on research opportunities and support for HUG students. The influence on the HUG students’ career choice and their accessibility of information will be evaluated by pre-study and post-study surveys. The research outcome will offer suggestions to create a safe and supportive departmental environment for HUG-identifying students to pursue research careers.
Lipid-engineered nanotherapeutics for cancer management

Cancer causes significant mortality and morbidity worldwide, but existing pharmacological treatments are greatly limited by the inherent heterogeneity of cancer as a disease, as well as the unsatisfactory efficacy and specificity of therapeutic drugs. Biopharmaceutical barriers such as low permeability and poor water solubility, along with the absence of active targeting capabilities, often result in suboptimal clinical results. The difficulty of successfully reaching and destroying tumor cells is also often compounded with undesirable impacts on healthy tissue, including off-target effects and high toxicity, which further impair the ability to effectively manage the disease and optimize patient outcomes. However, in the last few decades, the development of nanotherapeutics has allowed for the use of rational design in order to maximize therapeutic success. Advances in the fabrication of nano-sized delivery systems, coupled with a variety of surface engineering strategies to promote customization, have resulted in promising approaches for targeted, site-specific drug delivery with fewer unwanted effects and better therapeutic efficacy. These nano systems have been able to overcome some of the challenges of conventional drug delivery related to pharmacokinetics, biodistribution, and target specificity. In particular, lipid-based nanosystems have been extensively explored due to their high biocompatibility, versatility, and adaptability. Lipid-based approaches to cancer treatment are varied and diverse, including liposomal therapeutics, lipidic nanoemulsions, solid lipid nanoparticles, nanostructured lipidic carriers, lipid-polymer nanohybrids, and supramolecular nanolipidic structures. This review aims to provide an overview of the use of diverse formulations of lipid-engineered nanotherapeutics for cancer and current challenges in the field, as researchers attempt to successfully translate these approaches from bench to clinic.
Recent Progress of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Ocular Drug Delivery Platforms

Sufficient ocular bioavailability is often considered a challenge by the researchers, due to the complex structure of the eye and its protective physiological mechanisms. In addition, the low viscosity of the eye drops and the resulting short ocular residence time further contribute to the observed low drug concentration at the target site. Therefore, various drug delivery platforms are being developed to enhance ocular bioavailability, provide controlled and sustained drug release, reduce the number of applications, and maximize therapy outcomes. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) exhibit all these benefits, in addition to being biocompatible, biodegradable, and susceptible to sterilization and scale-up. Furthermore, their successive surface modification contributes to prolonged ocular residence time (by adding cationic compounds), enhanced penetration, and improved performance. The review highlights the salient characteristics of SLNs and NLCs concerning ocular drug delivery, and updates the research progress in this area.
Studies in nanofiltration of dyes industry effluent

ABSTRACT A large number of chemicals are being produced in the industries, which resulted in accumulation in the effluent stream. The impact of these effluents on the environment is very adverse, if it released directly without treatment. Nowadays, the treatment of the effluent before discharge is very important due to strict norms imposed by various government agencies. In our study, the effluent from a local effluent treatment plant (effluent from dyes factory) was procured and treated with hydrophilic polymeric and ceramic nanofiltration membranes. The membrane characterisation was done based on flux, permeability, flux recovery ratio, and flux decline ratio. The effluent received from ETP and treated effluent was characterised in terms of pH, total dissolved solids (TDS), Chemical Oxygen Demand (COD), Conductivity, Turbidity, and Osmolality. From our experimental study, more encouraging results were obtained. More than 50% COD reduction was observed in the process. The membrane flux was recovered by the physical (by using backwashing) and chemical process (by using sodium hypochlorite solution). The different range was used for optimising the appropriate process for recovery of membrane flux. About 95% membrane flux was recovered by physical process on both ceramic and polymeric membranes. GRAPHICAL ABSTRACT
The local time of a two-dimensional diffusion

When a markovian random process taking values in a continuous state-space, such as R, visits a particular point repeatedly, it is natural to seek some quantity which records how long it spends there. Typically, however, the number of visits made to the point is uncountably infinite, and the (Lebesgue) length of time spent there is zero. One interesting object to consider is the local time, sometimes thought of as the occupation density of the process, which at each point is a random Cantor function that increases only when the process visits the point. The review article by Rogers (1989) contains a good introduction to the local time of a one-dimensional brownian motion and its relevance to the excursions of brownian motion from zero. In two dimensions, a typical diffusion, such as brownian motion in the plane, never revisits a point, so it does not have a local time. In this paper we shall construct the local times of some particular two-dimensional diffusions on a one-dimensional subspace, and show that they are jointly continuous in both time and space.
Autophagy: A Potential Therapeutic Target to Tackle Drug Resistance in Multiple Myeloma

Multiple myeloma (MM) is the second most prevalent hematologic malignancy. In the past few years, the survival of MM patients has increased due to the emergence of novel drugs and combination therapies. Nevertheless, one of the significant obstacles in treating most MM patients is drug resistance, especially for individuals who have experienced relapses or developed resistance to such cutting-edge treatments. One of the critical processes in developing drug resistance in MM is autophagic activity, an intracellular self-digestive process. Several possible strategies of autophagy involvement in the induction of MM-drug resistance have been demonstrated thus far. In multiple myeloma, it has been shown that High mobility group box protein 1 (HMGB1)-dependent autophagy can contribute to drug resistance. Moreover, activation of autophagy via proteasome suppression induces drug resistance. Additionally, the effectiveness of clarithromycin as a supplemental drug in treating MM has been reported recently, in which autophagy blockage is proposed as one of the potential action mechanisms of CAM. Thus, a promising therapeutic approach that targets autophagy to trigger the death of MM cells and improve drug susceptibility could be considered. In this review, autophagy has been addressed as a survival strategy crucial for drug resistance in MM.
Evaluating the potential of innovations across aquaculture product value chains for poverty alleviation in Bangladesh and India

Evidence is presented that innovation across aquaculture value chains can contribute to poverty reduction through income generation and increased consumption of nutritious aquatic foods. Innovation is defined and contextualized in relation to aquaculture development. Opportunities for aquaculture innovation across value chains for poverty reduction and sustainable production are described. Contemporary trends in aquaculture development in Bangladesh and India, with a focus on 2011-2020, are reviewed, as understanding transformative change to aquatic food systems during this period could benefit millions of poor and marginal consumers. Market-led commercial production, instigated by private sector entrepreneurs for domestic markets, has underpinned the surge in freshwater fish culture in key geographical locations. In contrast booms in shrimp production have been associated with export opportunities and related cycles of boom-and-bust have been described, with busts attributed to falling market prices and disease outbreaks. Innovation could safeguard supplies of affordable fish to poorer groups (especially young children and pregnant and breastfeeding women) and enable better health management of aquatic animals including coordination of surveillance and disease control measures. Innovation to effectively promote better management practices and integrated services provision to large numbers of small- and medium-scale producers could contribute to poverty reduction. Opportunities for future innovation to ensure that aquaculture development is sustainable are critically reviewed. Innovative strategies to add value to by-products and utilize waste resources could avoid negative environmental impacts, recycle nutrients and create income generating opportunities. A new paradigm for development assistance that identifies and supports promising innovation trajectories across jurisdictions, product value chains, institutional regimes and food systems is needed. Government agencies must be responsive to the needs of businesses throughout aquatic food systems and devise policies and regulatory regimes that support transformative and sustained growth of the aquaculture sector. Investment in capacity-building, education, research and training and action to promote an enabling institutional environment must be regarded as essential elements to maximize and share equitably the benefits arising and avoid potential negative impacts of inappropriate innovations.