Miracle-dz/UniFAR-FTUs huggingface dataset:
ISW in ΛCDM or something else?

We investigate a correlation between the Planck’s CMB temperature map and statistics based on the space density of quasars in the SDSS catalogue. It is shown that the amplitude of the positive correlation imposes a lower limit on the amplitude of the Integrated Sachs–Wolfe effect independent of the quasar bias factor. Implications of this constraint for the ISW effect in the Λ cold dark matter (ΛCDM) model are examined. Strength of the correlation indicates that the rms of temperature fluctuations associated with the quasars distributed between 1500 and 3000 Mpc likely exceeds $11{\! -\! }12\, \mu$K. The signal seems to be related to an overall space distribution of quasars rather than to a few exceptionally dominant structures like supervoids. Although, the present estimates are subject to sizable uncertainties, the signal apparently exceeds the model predictions of the ISW effect for the standard ΛCDM cosmology. This conclusion is consistent with several other investigations that also claim some disparity between the observed ISW signal and the theoretical predictions.
GENDER DIFFERENCES IN THE INFLUENCE OF COMORBID CONDITIONS ON THE LONG-TERM OUTCOMES OF PATIENTS WITH ACUTE CORONARY SYNDROME

Background. Gender differences in the baseline characteristics of patients with the acute coronary syndrome (ACS) have been widely acknowledged. Women are known to be generally older with a higher prevalence of comorbidities. Objectives. Gender differences in the baseline characteristics of patients with the acute coronary syndrome (ACS) have been widely acknowledged. Women are known to be generally older with a higher prevalence of comorbidities. At the same time, it is now yet clear which comorbid conditions have the most significant impact on the long-term outcomes of patients with ACS and if there are any gender differences in this respect. Methods. We performed a retrospective cohort study of 167 patients (109 men and 58 women) admitted to the acute coronary unit of Ternopil Municipal Hospital with ACS in 2016-2017. All relevant clinical information has been recorded in the pre-designed data charts. The incidence of repeated major adverse cardiovascular events (MACEs) has been assessed over 36 months after the hospital discharge via an e-Health electronic system. Results. In this cohort, female patients with ACS had a higher prevalence of comorbid conditions: 15.5% of women vs. 11% of men with ACS had ≥5 comorbidities, 65.5% of women and 60% of men had 2-4 comorbid conditions, and 19% of women vs. 29% ≤1 concomitant disease. The comorbidity structure also differed between genders. Women more often had concomitant cerebrovascular diseases (17.2% vs. 7.3%, p=0.05), dementia (15.5% vs. 5.5 %, p=0.03), connective tissue disorders (17.25 vs. 6.42%, p=0.03) and thyroid disease (12.1% vs. 2.8%, p=0.02). Men more often suffered from peptic ulcer (13.7% vs. 3.4%, p=0.05). The incidence of MACEs during the follow-up period rose sharply with age and was higher in females (55% vs. 33%, p=0.003). In the multivariable model, PAD (OR 9.5, 95% CI: 1.7-52.3, p=0.01) and thyroid disease (OR 7.2, 95% CI: 1.19-43.2, p=0.03) demonstrated the most significant impact on the long-term event-free survival of females in the cohort. In turn, a solid metastatic tumor was the most significant predictor of poor prognosis in men (OR 6.3, 95% CI: 2.13-18.9, p=0.001). Conclusions. We observed significant gender differences in the prevalence of comorbid conditions and their influence on the three-year event-free survival of patients with ACS. The predictive value of comorbidities should be further investigated, preferably, with the involvement of larger cohorts.
Herpetic Keratitis Following Corneal Crosslinking for Keratoconus: A Case Series

Background Corneal crosslinking is widely applied to enhance corneal biomechanical properties and delay the progression of keratoconus. The surgical procedure and application of ultraviolet A irradiation (UVA) during corneal crosslinking have been recognized to induce the reactivation of simplex herpes virus (HSV) but are rarely reported and poorly analyzed. Case Presentation We report the first case series of herpetic keratitis in 4 keratoconus patients undertaking corneal crosslinking, who were all clinically diagnosed at routine follow-up visits 3 days to 1 month after the surgery. Different from the typical new onset of secondary herpetic keratitis that mainly presents with epithelial lesions and severe eye pain, these patients all presented with stromal infiltrates and were generally asymptomatic except for vision blurring in 2 patients. All patients responded well to antiviral therapy, topical steroids, and epithelial nourishment medication, leaving corneal macula or nebula at the last follow-up visit. Conclusion Close follow-up is essential and the most effective way to diagnose herpetic keratitis after corneal crosslinking due to the lack of subjective symptoms. The prophylactic use of antiviral therapy on asymptomatic patients is controversial and should be evaluated based on long-term prognosis.
Application of Computational Biology and Artificial Intelligence in Drug Design

Traditional drug design requires a great amount of research time and developmental expense. Booming computational approaches, including computational biology, computer-aided drug design, and artificial intelligence, have the potential to expedite the efficiency of drug discovery by minimizing the time and financial cost. In recent years, computational approaches are being widely used to improve the efficacy and effectiveness of drug discovery and pipeline, leading to the approval of plenty of new drugs for marketing. The present review emphasizes on the applications of these indispensable computational approaches in aiding target identification, lead discovery, and lead optimization. Some challenges of using these approaches for drug design are also discussed. Moreover, we propose a methodology for integrating various computational techniques into new drug discovery and design.
Spatially adaptive radiation-hydrodynamical simulations of galaxy formation during cosmological reionization

We present a suite of cosmological radiation-hydrodynamical simulations of the assembly of galaxies driving the reionization of the intergalactic medium (IGM) at z >~ 6. The simulations account for the hydrodynamical feedback from photoionization heating and the explosion of massive stars as supernovae (SNe). Our reference simulation, which was carried out in a box of size 25 comoving Mpc/h using 2 x 512^3 particles, produces a reasonable reionization history and matches the observed UV luminosity function of galaxies. Simulations with different box sizes and resolutions are used to investigate numerical convergence, and simulations in which either SNe or photoionization heating or both are turned off, are used to investigate the role of feedback from star formation. Ionizing radiation is treated using accurate radiative transfer at the high spatially adaptive resolution at which the hydrodynamics is carried out. SN feedback strongly reduces the star formation rates (SFRs) over nearly the full mass range of simulated galaxies and is required to yield SFRs in agreement with observations. Photoheating helps to suppress star formation in low-mass galaxies, but its impact on the cosmic SFR is small. Because the effect of photoheating is masked by the strong SN feedback, it does not imprint a signature on the UV galaxy luminosity function, although we note that our resolution is insufficient to model star-forming minihaloes cooling through molecular hydrogen transitions. Photoheating does provide a strong positive feedback on reionization because it smooths density fluctuations in the IGM, which lowers the IGM recombination rate substantially. Our simulations demonstrate a tight non-linear coupling of galaxy formation and reionization, motivating the need for the accurate and simultaneous inclusion of photoheating and SN feedback in models of the early Universe.
Separate chemical freeze-out of strange particles with conservation laws

The Hadron Resonance Gas Model with two chemical freeze-outs, connected by conservation laws is considered. We are arguing that the chemical freeze-out of strange hadrons should occur earlier than the chemical freeze-out of non-strange hadrons. The hadron multiplicities measured in the heavy ion collisions for the center of mass energy range 2.7 - 200 GeV are described well by such a model. Based on a success of such an approach, a radical way to improve the Hadron Resonance Gas Model performance is suggested. Thus, we suggest to identify the hadronic reactions that freeze-out noticeably earlier or later that most of the others reactions (for different collision energies they may be different) and to consider a separate freeze-out for them.
Extracting limits on Dark Matter annihilation from gamma-ray observations towards dwarf spheroidal galaxies

Dwarf spheroidal galaxies compose one of the most dark matter dominated classes of objects, making them a set of targets to search for signals of dark matter annihilation. Recent developments in gamma-ray astronomy, most importantly the launch of the Fermi-LAT instrument, have brought those targets into attention. Yet, no clear excess of gamma-rays has been confirmed from these targets, resulting in some of the tightest limits on dark matter annihilation from indirect searches. In extracting limits from dwarf spheroidal galaxies, it is of great importance, to properly take into account all relevant uncertainties. Those include the dark matter distribution properties of the dwarf spheroidals and the uncertainties on the underlying background. We revisit the limits on dark matter annihilation, from gamma-rays studying a set of close-by dwarf spheroidal galaxies, for which, we have good understanding of the uncertainties in the dark matter distribution. For those targets, we perform and compare results for alternative methods in extracting the background gamma-ray flux. This provides a method to discriminate among the dark matter annihilation targets, those that can give robust constraints. We finally present our tightest limits on dark matter annihilation, that come only from the targets that ensure accurate understanding of both the gamma-ray background and the dark matter distribution uncertainties.
Extraordinary waves in two dimensional electron gas with separate spin evolution and Coulomb exchange interaction

Hydrodynamics analysis of waves in two-dimensional degenerate electron gas with the account of separate spin evolution is presented. The transverse electric field is included along with the longitudinal electric field. The Coulomb exchange interaction is included in the analysis. In contrast with the three-dimensional plasma-like mediums the contribution of the transverse electric field is small. We show the decrease of frequency of both the extraordinary (Langmuir) wave and the spin-electron acoustic wave due to the exchange interaction. Moreover, spin-electron acoustic wave has negative dispersion at the relatively large spin-polarization. Corresponding dispersion dependencies are presented and analyzed.
Scoparone inhibits the growth of liver cancer cells by regulating MAPK signaling pathway

Purpose: To investigate the possible effects of scoparone on the viability, apoptosis and motility of liver cancer cells, as well as the mechanism of action. Methods: CCK-8 and colony formation assays were carried out to determine liver cancer cell viability, while flow cytometry (FCM) and Immunoblot assays were performed to evaluate cell apoptosis. Wound closure and Transwell assays were performed to determine the effect of scoparone on cell motility, while immunoblot assays were performed to assess the effect of the compound on MAPK pathway of liver cancer cells. Results: Scoparone suppressed the viability of Hep3B2 and Huh-7 cells (p < 0.01), as well as the apoptosis and motility of the cells (p < 0.01). Furthermore, scoparone inhibited the growth of liver cancer cells via MAPK pathway. Conclusion: Scoparone suppresses liver cancer cell growth via MAPK pathway, and is thus a promising drug for liver cancer treatment. However, in vivo studies are required to validate these findings.
Housekeeping entropy in continuous stochastic dynamics with odd-parity variables

We investigate the decomposition of the total entropy production in continuous stochastic dynamics when there are odd-parity variables that change their signs under time reversal. The first component of the entropy production, which satisfies the fluctuation theorem, is associated with the usual excess heat that appears during transitions between stationary states. The remaining housekeeping part of the entropy production can be further split into two parts. We show that this decomposition can be achieved in infinitely many ways characterized by a single parameter σ. For an arbitrary value of σ, one of the two parts contributing to the housekeeping entropy production satisfies the fluctuation theorem. We show that for a range of σ values this part can be associated with the breakage of the detailed balance in the steady state, and can be regarded as a continuous version of the corresponding entropy production that has been obtained previously for discrete state variables. The other part of the housekeeping entropy does not satisfy the fluctuation theorem and is related to the parity asymmetry of the stationary state distribution. We discuss our results in connection with the difference between continuous and discrete variable cases especially in the conditions for the detailed balance and the parity symmetry of the stationary state distribution.
Evidence of a fractional quantum Hall nematic phase in a microscopic model

At small momenta, the Girvin-MacDonald-Platzman (GMP) mode in the fractional quantum Hall (FQH) effect can be identified with gapped nematic fluctuations in the isotropic FQH liquid. This correspondence would be exact as the GMP mode softens upon approach to the putative point of a quantum phase transition to a FQH nematic. Motivated by these considerations as well as by suggestive evidence of an FQH nematic in tilted field experiments, we have sought evidence of such a nematic FQHE in a microscopic model of interacting electrons in the lowest Landau level at filling factor 1/3. Using a family of anisotropic Laughlin states as trial wave functions, we find a continuous quantum phase transition between the isotropic Laughlin liquid and the FQH nematic. Results of numerical exact diagonalization also suggest that rotational symmetry is spontaneously broken, and that the phase diagram of the model contains both a nematic and a stripe phase.
Adaptive fine-tuning strategy for few-shot learning

Abstract. Few-shot classification aims to recognize innovative classes that lack enough labeled examples. Existing few-shot learning methods train a model on the source dataset and transfer knowledge to the target dataset. However, the trained model cannot generalize well to unseen tasks, especially when there are domain shifts. To address the aforementioned limitation, we propose an adaptive fine-tuning strategy to improve the generalizability of the pre-trained model. Our core idea is adaptively transferring target-task-specific knowledge to different target tasks. Specifically, we perform an evolutionary search on the task-specific validation dataset similar to the target dataset. Class hierarchy structure is introduced to seek the closest validation super class of the novel class. Meanwhile, our work takes the evolutionary searched model instead of the pretrained network serving as the initialization of fine-tuning. Extensive experiments proceeded and demonstrate the effectiveness of our adaptive fine-tuning strategy. Furthermore, our proposed method can be easily combined with meta-learning and transfer learning methods to improve their generalizability.
ACUTE TOXICITY TEST OF ETHANOL EXTRACT OF SUNGKAI LEAF (Peronema canescens Jack) IN WHITE MICE (Mus musculus)

Sungkai (Peronema canescens) is a type of plant that can be used in traditional medicine in Jambi, Indonesia. The purpose of the study was to determine the value of LD50 from the results of the acute toxicity test of LD50 ethanol extract of Sungkai leaves (Peronema canescens) in male and female white mice (Mus musculus). This research method is experimental research in the laboratory used 50 mice comprising 25 males and 25 females which are divided into 5 groups, normal control (Na-CMC 1%), ethanol extract (625 mg/kg body weight), ethanol extract (1,250 mg/kg body weight), ethanol extract (2,500 mg/kg body weight) and ethanol extract (5,000 mg/kg body weight). The test preparation is administered orally through the gastric sonde and is administered only once in 24 hours. The Indonesian Pharmacopoeia Edition III method was used to calculate the value of LD50 in this study. The results of the acute toxicity test of LD50 Sungkai leaf ethanol extract are included in the safe category in the male animal group. In the group of female animals, an LD50 value of 6.50 mg/kg body weight was got. They include it in the category of very toxic and dangerous for the group of female animals. On the data on the ratio of organ weights in each research organ. Only in the male group, there was no noticeable difference (P>0.05) in each organ, but in the female group of animals, there were noticeable differences (p<0.05) in the heart, liver, lungs, kidneys, and stomach organs.
Decadal Assessment and Distribution of Rainfall Anomaly Index (1991 – 2020) for Benin City, Edo State, Nigeria

This study was designed to provide valuable insight into the temporal patterns of rainfall in Benin City, Edo State, Nigeria using rainfall data from 1991 – 2020 (30 years) collected from Nigerian Meteorological Agency (NIMET), airport station, Benin City. The data were assessed based on 10 years interval (decade) identified as decadal A (1991-2000), decadal B (2001-2010) and decadal C (2011-2020). The data was analysed descriptively using charts and graphs. Also, Rainfall Anomaly Index (RAI) was determined for each decadal. Findings from the study reveal that rainfall pattern changes significantly based on statistics for each decadal. In decadal A, rainfall usually began in the month of July to October, June to September in decadal B while May to September in decadal C with rainfall going above the annual precipitation (2679 mm) for the City. The rainfall anomaly over the city revealed that there was a composite nature in which some dry years were mixed with wet years and vice versa and this occurred in all decades. RAI revealed that decadal C recorded the highest number of years (7) of intense rainfall compared to decadal A and B. The trend for the average annual rainfall showed a significant trend based on the decade. The average annual rainfall increased with time (decade) as the trend rose from 1886.9 mm in decade A to 1890.0mm in decade B and 2078.8 mm in decade C. The year of greatest positive value was 2016 (decadal C), with an average RAI of 6.53 classified as extremely humid. Based on these findings, the study concludes that the climate in Benin City has significantly changed.
Dark matter search in the inner Galactic halo with H.E.S.S. I and H.E.S.S. II

The presence of dark matter in the Universe is nowadays widely supported by a large body of astronomical and cosmological observations. One of the best targets to look for dark matter particle self-annihilation into very high energy gamma-rays is the Galactic Center (GC) region. A search for annihilating dark matter in the central 300 parsecs around the GC is performed with the H.E. S.S. array of ground-based Cherenkov telescopes. Using the full H.E. S.S. I dataset (2004-2014) for this region, new constraints are derived on the velocity-weighted annihilation cross section with a 2D likelihood method, taking advantage of differences in both spectral and spatial morphologies of signal and background. Higher statistics from the 10-years GC dataset of H.E. S.S. I together with a novel analysis technique, allow to improve the present constraints by a factor of 2 for a DM particle mass of 1 TeV. The expected improvement in sensitivity of the new analysis technique, applied to performances of the H.E. S.S. -II array, is also presented.
Effects of replacing the protein content of Azolla Pinnata with concentrate on physiological and blood profiles changes in Sahiwal calves

Recommended Citation BHATT, NINAD; CHANDRA, RAMESH; CHIKKAGOUDARA, Kotresh Prasad; KANDPAL, DIKSHA; MISRA, DEEPESH BHARAT; and TYAGI, NITIN (2022) "Effects of replacing the protein content of Azolla Pinnata with concentrate on physiological and blood profiles changes in Sahiwal calves," Turkish Journal of Veterinary & Animal Sciences: Vol. 46: No. 5, Article 7. https://doi.org/10.55730/1300-0128.4247 Available at: https://journals.tubitak. gov.tr/veterinary/vol46/iss5/7
The Relationship Between the Thickness of cpRNFL in Segments and Intraocular Pressure

Purpose The aim of this study was to investigate whether the retinal nerve fibre layer (RNFL) in some segments of the optic nerve disc in pathological intraocular pressure is more damaged in eyes without antiglaucoma treatment. Patients and Methods The cohort consisted of 69 subjects (122 eyes), 32 males (6x one, 26x both eyes) aged 21 to 76 years and 37 females (4x one and 30x both eyes) aged 22 to 75 years, who were measured to have IOP greater than 21 mmHg (21–36) in routine ambulatory care. Measurements were performed using the Ocular Response Analyser, taking into account corneal hysteresis. RNFL thickness was measured using the Avanti RTVue XR and was assessed in 8 segments (1-IT, 2-TI, 3-TS, 4-ST, 5-SN, 6-NS, 7-NI, 8-IN). The visual field was examined with a fast threshold glaucoma program using the Medmont M700. The overall defect (OD) was evaluated. Pearson’s correlation coefficient r was used to assess the dependence between the selected parameters. Results The largest peripapillary changes in RNFL were observed in segments 1, 4, 5 and 8. It should be emphasized that segments 1 and 4 have been temporarily shifted. Segments 5 and 8 then corresponded to the upper (at no. 12) and lower (at no. 6) sectors. Conclusion The most important result of this study is the finding that the greatest changes in the RNFL layer were observed in pathological IOP at segment 5 (r=−0.3) and 8 (r=−0.28), at the point where the fibres of the magnocellular retinal ganglion cells enter the retina.