Miracle-dz/UniFAR-FTUs huggingface dataset:
The prognostic importance of red blood cell distribution width for gastric cancer: a systematic review and meta-analysis

Background For cancer patients, red blood cell distribution width (RDW) is a readily accessible and cost-effective preoperative prognostic predictor. This study aimed to determine whether RDW is a predictive factor for individuals undergoing radical surgery for gastric cancer (GC). Methods A literature search was performed to select relevant studies for inclusion in the subsequent meta-analysis. Relevant data were pooled to assess the association between RDW and GC results, including overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS), as well as clinicopathological features. Results The meta-analysis and systemic review included data from 8 studies comprising 1,587 individuals diagnosed with GC. In this context, RDW refers to the coefficient of variation of RDW (RDW-CV). A high level of RDW-CV was significantly associated with older age [odds ratio (OR) =2.25; 95% confidence interval (CI): 1.72–2.94; P<0.00001], larger tumor diameter (OR =1.90; 95% CI: 1.42–2.56; P<0.0001), and vascular invasion (OR =2.22; 95% CI: 1.10–4.49; P=0.03). After hazard ratios (HRs) and 95% CIs were pooled, RDW-CV was found to be an independent prognostic factor of OS (HR =1.79; 95% CI: 1.21–2.66; I2=85%; P=0.004), DFS (HR =1.81; 95% CI: 1.37–2.39; I2=0%; P<0.0001), and CSS (HR =2.73; 95% CI: 1.36–5.49; I2=0%; P=0.005) in patients with GC. Conclusions The association between high levels of RDW-CV and poor survival in GC suggests that RDW-CV may be a viable prognostic indicator for patients with GC.
Identification of Medication Prescription Errors and Factors of Clinical Relevance in 314 Hospitalized Patients for Improved Multidimensional Clinical Decision Support Algorithms

Potential medication errors and related adverse drug events (ADE) pose major challenges in clinical medicine. Clinical decision support systems (CDSSs) help identify preventable prescription errors leading to ADEs but are typically characterized by high sensitivity and low specificity, resulting in poor acceptance and alert-overriding. With this cross-sectional study we aimed to analyze CDSS performance, and to identify factors that may increase CDSS specificity. Clinical pharmacology services evaluated current pharmacotherapy of 314 patients during hospitalization across three units of two Swiss tertiary care hospitals. We used two CDSSs (pharmaVISTA and MediQ), primarily for the evaluation of drug-drug interactions (DDI). Additionally, we evaluated potential drug-disease, drug-age, drug-food, and drug-gene interactions. Recommendations for change of therapy were forwarded without delay to treating physicians. Among 314 patients, automated analyses by both CDSSs produced an average of 15.5 alerts per patient. In contrast, additional expert evaluation resulted in only 0.8 recommendations per patient to change pharmacotherapy. For clinical pharmacology experts, co-factors such as comorbidities and laboratory results were decisive for the classification of CDSS alerts as clinically relevant in individual patients in about 70% of all decisions. Such co-factors should therefore be used for the development of multidimensional CDSS alert algorithms with improved specificity. In combination with local expert services, this poses a promising approach to improve drug safety in clinical practice.
Microextensometry and mechanical behaviour of Haversian cortical bone

It is well known that bone microarchitecture is mainly the result of the bone remodelling process. However, a mechanistic framework describing how the microstructure affects the mechanical behaviour of bone is still lacking. Therefore, tools to quantify bone quality at the microstructure scale are required. To address this problem, the present study focused on the measurements of the local strains over a large microstructure area using microextensometry. First, the relationship between the local strains and the mineral content was examined. Then, the local strains were used to feed an inverse approach performed by finite elements. The results show there is no correlation between the strain and the mineral content. Moreover, the implementation of the mineral content in finite elements simulations gave a better estimate of the experimental strain field.
Research and Application of Network Router Link Prediction Method

Multiple Autonomous systems (ASes) of the network are usually consisted of many routers such as inter-router and intra-router connection each other. In order to detect the network routers connection relationship, many researchers at home or abroad use various methods such as active end-to-end links detection or observing SNMP MIBs to understand the links’ connection relationship among the routers in network’ ASes. In this paper, by using the link prediction algorithm based on the similarity, we tried to predict the links’ connection relationship and got the possible network topology structure among the network’ ASes when the actual connection link don’t be completely detected. Through the experiments, the prediction results can be seen that the similarity algorithm index of ACT, SRW, and SimRank based on the random walk can also achieve better prediction accuracy above 0.95, which prove the similarity index especially the random walk algorithm can realize the higher link prediction accuracy to the network’ ASes under the conditions of missing some known connection link, etc.
Abnormal structural alterations and disrupted functional connectivity in behavioral addiction: A meta-analysis of VBM and fMRI studies

Abstract Background Altered large-scale brain systems, including structural alterations and resting-state functional connectivity (rs-FC) changes, have been demonstrated as effective system-level biomarkers for revealing potential neural mechanism of multiple brain disorders. However, identifying consistent abnormalities of large-scale brain systems in behavioral addictions (BA) is challenging due to varying methods and inconsistent results. Therefore, the aim of this study was to identify the significantly abnormal large-scale brain systems in BA. Method PubMed, OVID Embase, OVID Medline, and Web of Science were searched with relevant keywords to identify potential studies. A total of 52 studies including 35 rs-FC studies and 17 structural studies were examined by extracting the coordinates of seeds and target brain regions. The seeds were then categorized into predefined seven networks by their locations based on previous parcellations in rs-FC studies, followed by pooling the results in those networks. Results The rs-FC findings illustrated that BA were characterized as abnormal networks in response to inhibition, salience attribution, self-referential mental process, and reward-driven behaviors. Meanwhile, meta-analysis of structural studies showed decreased gray matter volume in the anterior cingulate cortex, extending to the middle cingulate cortex and the superior frontal gyrus. Importantly, overlapping regions in the cingulate cortex and anterior thalamus projections extending to caudate regions exhibited both dysfunctions in structure and rs-FC. Conclusions This study highlighted substantial dysconnectivity in BA, which might result in impaired response to inhibition and salience attribution. Therefore, this study might provide novel insights of neural biomarkers for clinical diagnoses and treatment targets for BA.
Electromagnetic (EM) Quantification of the Microwave Antenna for the Transurethral Prostatic Thermotherapy

Experiments were performed in a tissue microwave equivalent phantom gel to quantitatively examine the volumetric heating produced by a microwave antenna with a peripheral cooling system for the transurethral prostatic thermotherapy. The volumetric heat strength. which is determined by the specific absorption rate (SAR) of microwave energy in the gel, was calculated from the initial transient temperatures at various locations within the phantom gel. Based on previous research. expression for the SAR distribution was extended to three dimensions. which includes its dependence on radial, angular and axial direction. The parameters in this expression and the convection coefficient due to the chilled water running around the antenna were determined using a least-square residual fit of the analytical predictions to the experimental SAR measurements. The analytical expression of the three-dimensional SAR distribution obtained in this study will help provide a better understanding of the microwave heating pattern in the prostatic tissue and thus to aid in designing improved applicators. It can also be used in the future as an accurate input to heat transfer models to predict temperature distributions during the transurethral microwave thermotherapy.
ANALYSIS OF THE INFLUENCE OF EWOM, PROMOTION AND EASE OF USE OF DISNEY+ HOTSTAR SERVICES ON SUBSCRIPTION DECISIONS IN JAKARTA CITY

The purpose of this study was to analyze the effect of EWOM, Promotion and Ease of Use on Disney+ Hotstar Subscription Decisions. To obtain all the data needed, the researchers used Primary Data, namely by using an Online Questionnaire. The analytical method in this study used quantitative primary data, the test stages carried out were: Test Validity, Reliability, Normality, Multicollinearity, Heteroscedasticity, t test, F test, Multiple Linear Regression and Coefficient of Determination. The data used in this study used a questionnaire instrument, and 100 respondents collected valid data. The sampling method in this study was Non-Probability Sampling with Purposive Sampling technique. The testing tool used is SPSS Ver 25. The results showed that (1) EWOM and Ease of Use have no partial effect on Subscription Decisions (2) Promotion has a partial effect on Subscription Decisions (3) EWOM, Promotion and Ease of Use have an effect simultaneously on purchasing decisions.
Search for Neutrino Emission at the Galactic Center Region with IceCube

The Galactic Center (GC) region has long been subject to intense interest within the astrophysics community. At the GC, a strong radio source has been detected and identified as the super-massive black hole, Sgr. A*, which significantly affects the dynamics of the GC region within 300 parsecs. Many interesting astrophysical objects, including supernova remnants, high-mass X-ray binaries, pulsar wind nebulae, among others, have been found in this region. These objects are expected to produce high energy neutrinos, possibly in a transient manner, which can potentially be observed with the IceCube Neutrino Observatory. Due to the geographical location of the IceCube Neutrino Observatory, a large amount of cosmic-ray muons reduces IceCube’s sensitivity in the southern sky, where the GC is located. Thus, a dedicated event selection is performed to reduce this background and optimize the sensitivity. In this talk, we present this event selection in the GC region with IceCube data using classical and machine learning methods. This new dataset will be used to perform a time-dependent search for single flares at the GC.
Linguistic typology in natural language processing

Abstract This paper explores the ways in which the field of natural language processing (NLP) can and does benefit from work in linguistic typology. I describe the recent increase in interest in multilingual natural language processing and give a high-level overview of the field. I then turn to a discussion of how linguistic knowledge in general is incorporated in NLP technology before describing how typological results in particular are used. I consider both rule-based and machine learning approaches to NLP and review literature on predicting typological features as well as that which leverages such features.
Vibrational energy harvesting using a multi-degree-of-freedom device

This paper focuses on modelling a prototype energy harvester, for converting mechanical energy from the environment into electrical energy, based around an L-shaped beam subject to base excitation. It is possible to tune the first two natural frequencies of this structure to investigate a phenomenon known as auto-parametric resonance which effectively creates a time-varying stiffness within the system. We present a hierarchy of models: a reduced order model, which demonstrates the qualitative features of the energy harvester, and a more realistic continuum model which can, in future, be used to investigate the quantitative performance. Analysis of this prototype harvester should provide clues towards the types of nonlinearities that are useful to incorporate into future energy harvesters.
Investigating An Adoption Of Smartphone: A Road To Ubiquitous Business Management

Telecommunication technology through smartphones currently provides many benefits and convenience to users. However, not all users are optimizing their smartphones. Currently, there are minimal knowledge of the reasons that entrepreneurs adopted and used smartphones to manage the organization and business. For this purpose, the operational framework applied to this research was adapted from Unified theory of Acceptance and Use of Technology. This quantitative approach research through questionnaires examined104respondents’ perception on social influence, facilitating conditions, performance expectancy, effort expectancy, the importance of adopting and use of smartphones within entrepreneurs for managing business. The contribution of this research revealed the significant of smartphone usage for business management. The outcomes of this investigation indicated that there was no significant social influence toward entrepreneurs to use smartphone for managing business. Overall, entrepreneurs believed that smartphone was easy to use and managing business using smartphone can help them increase their performance. This contributed to an increase in their intention to use them. However, the findings showed that the smartphone usage for business management by entrepreneurs is low. Regarding the limitations, these happened because of finance and time factor. To overcome the limitations, this research recommends further studies that apply qualitative research.
Infrared Imaging Using Microcantilevers

A micromechanical detector using microcantilever for infrared (IR) radiation is demonstrated. Because of their small size and low thermal mass, these microcantilever IR detectors are promising new family of IR sensors. This novel IR sensor is based on deflection due to IR adsorption induced thermal stress on a bimaterial cantilever which can be monitored with several methods such as optical deflection or piezoresistive. When laser-deflection-monitored Si4N4 microcantilevers coated with a 40nm thick coating of gold were irradiated by a low-power diode laser, the noise equivalent power and specific detectivity, NEP and D* were found to be 173pW/Hz and 7.18 × 108cmHz/W, respectively, when compensation for the laser reflectivity was made.
Mesodermal Derivatives of Pluripotent Stem Cells Route to Scarless Healing

Scar formation during normal tissue regeneration in adults may result in noticeable cosmetic and functional defects and have a significant impact on the quality of life. In contrast, fetal tissues in the mid-gestation period are known to be capable of complete regeneration with the restitution of the initial architecture, organization, and functional activity. Successful treatments that are targeted to minimize scarring can be realized by understanding the cellular and molecular mechanisms of fetal wound regeneration. However, such experiments are limited by the inaccessibility of fetal material for comparable studies. For this reason, the molecular mechanisms of fetal regeneration remain unknown. Mesenchymal stromal cells (MSCs) are central to tissue repair because the molecules they secrete are involved in the regulation of inflammation, angiogenesis, and remodeling of the extracellular matrix. The mesodermal differentiation of human pluripotent stem cells (hPSCs) recapitulates the sequential steps of embryogenesis in vitro and provides the opportunity to generate the isogenic cell models of MSCs corresponding to different stages of human development. Further investigation of the functional activity of cells from stromal differon in a pro-inflammatory microenvironment will procure the molecular tools to better understand the fundamental mechanisms of fetal tissue regeneration. Herein, we review recent advances in the generation of clonal precursors of primitive mesoderm cells and MSCs from hPSCs and discuss critical factors that determine the functional activity of MSCs-like cells in a pro-inflammatory microenvironment in order to identify therapeutic targets for minimizing scarring.
Religious and Racial/Ethnic Differences in Flu and COVID-19 Vaccination Intentions

ABSTRACT Vaccination is an effective public health initiative to reduce severe illness and death due to COVID-19. Vaccine uptake in the United States has been uneven, however. One proposed mechanism to improve vaccine uptake is to engage religious groups to provide health information and encourage vaccination. It remains unclear though if Americans with differing racial/ethnic identities and religious affiliations are equally likely to receive health-related information in religious settings and endorse COVID-19 vaccination. We assessed data from the 2020–2021 National Politics Study, which utilized a national research panel of U.S. adults. Using logistic regression and a treatment effects approach, we found that having heard health-related messages in religious settings and endorsing progressive religious ideology were associated with increased COVID-19 and flu vaccine acceptance. This relationship was stronger among White American worship-goers. These findings suggest that partnerships with religious organizations may be important if additional barriers to vaccination are also addressed.
Highly uniform 150 mm diameter multichroic polarimeter array deployed for CMB detection

The Advanced Atacama Cosmology Telescope Polarimeter is an upgraded receiver for the Atacama Cosmology Telescope, which has begun making measurements of the small angular scale polarization anisotropies in the Cosmic Microwave Background using the first of four new multichroic superconducting detector arrays. Here, we review all details of the optimization and characterization of this first array, which features 2012 AlMn transition- edge sensor bolometers operating at 150 and 230 GHz. We present critical temperatures, thermal conductivities, saturation powers, time constants, and sensitivities for the array. The results show high uniformity across the 150 mm wafer and good performance in the field.
Bladder Metastatic Breast Cancer Presenting Initially with Lower Urinary Tract Symptoms: A Rare Case Report

Introduction: Breast cancer (BC) is the most frequently diagnosed malignancy (25% of all cancers) and the leading cause of cancer-related death in women; death is mainly attributed to the metastatic spread of the primary tumor. On the other hand, secondary tumors of the bladder are rare, representing 2% of all bladder neoplasms. Breast cancer rarely spreads to the urinary bladder. Patients in almost all previous reports have been diagnosed with BC several months before the bladder metastasis (BM) was discovered. Case Presentation: A 67-year-old woman presented with irritative bladder symptoms with no history suggestive of BC. Normal breast examination and normal laboratory investigations with Breast Imaging Reporting and Data System 1 (BI-RADS 1) in mammographic evaluation challenged the pathological findings of the bladder biopsy that was positive for metastatized BC to the bladder. Conclusions: Metastatic BC may rarely initially present with irritative lower urinary symptoms and absent clinical and radiological features of BC-but positive histopathological findings.
Urolithin A as a Potential Agent for Prevention of Age-Related Disease: A Scoping Review

The aging of an organism is hallmarked by systemic loss of functional tissue, resulting in increased fragility and eventual development of age-related neurodegenerative, musculoskeletal, cardiovascular, and neoplastic diseases. Growing scientific evidence points to mitochondrial dysfunction as a key contributor in the aging process and subsequent development of age-related pathologies. Under normal physiologic conditions, the body removes dysfunctional mitochondria via an autophagic process known as mitophagy. Urolithin A (UA), a metabolite produced when gut microflora digests the polyphenol compounds ellagitannin and ellagic acid, is a known inducer of mitophagy via several identified mechanisms of action. The primary objective of this scoping review is to identify and summarize the clinical relevance of UA supplementation in the prevention of age-related pathology and diseases. A computer-assisted literature review was performed using PubMed and EMBASE for primary source research articles examining UA supplementation and aging-related pathologies. A total of 293 articles were initially identified from a database search, and 15 articles remained for inclusion in this review, based on predetermined criteria. Analysis of the 15 identified publications demonstrated that UA holds potential as a dietary intervention for slowing the progression of aging and preventing the development of age-related disease. This review also illustrates the potential role that mitochondrial health and inflammation play in the progression of age-related pathology. Identifying the clinical relevance of UA supplementation in the prevention of age-related pathology and diseases will help further the focus of research on treatments that may improve the longevity and quality of life in patients at risk for these comorbidities.
Generalized Extended State Observer Based Control for Networked Interconnected Systems with Delays

This paper is concerned with the generalized extended state observer based control for a class of networked interconnected systems with short time‐varying delays. First, the uncertainties induced by the delays are modeled as an additive bounded disturbance. Then, a novel state feedback stabilizing controller is designed based on generalized extended state observers (GESOs). The GESO is used to estimate the system state and the disturbance simultaneously, and the effect of the uncertainty induced by the delay is eliminated by the GESO based controller. Finally, an illustrative example is provided to verify the effectiveness of the proposed method.
Ovarian Histology and Histopathology of Olive Barb, Puntius sarana Exposed to Endocrine Disrupting Chemical (17-Α Methyl Testosterone) in Laboratory Condition

17-α methyl testosterone is a major endocrine disrupting chemical (EDCs), reported harmful effect on endocrine system of aquatic animals. To study the impact of 17-αMT on olive barb (Puntius sarana) gonad, sixty fishes were collected for in vitro experiment. Hormonal treatments were carried out 90 days with three distinct hormonal dosages (T1:40 mg/kg; T2:60 mg/kg and T3:90 mg/kg) mixed with pelleted feed and no hormone in control tank (C). Each 30 days intervals, histological analysis was performed to observe alterations in the gonad due to the effect of 17α-MT. Four gamete developmental stages of female P. sarana ovary were identified through microscopic examination named immature, previtellogenic, vitellogenic and mature stage. Mild to moderate histological abnormalities has been observed in ovary for different treatments. T1 showed apparently normal histology except some alterations like empty follicle (ef), lipid droplet (ld), vitelline envelop breakdown (veb), but pronounced alterations were detected at higher concentration T2 and T3, increasing with longer exposures for instance degenerated nucleus (dn), atretic follicle (af), thickened vitelline envelop (tve), residual oocyte (roc). This preliminary study revealed more profound responses to EDCs exposure in the olive barbs which could serve as a model bio-indicator in ecotoxicological study.