Miracle-dz/UniFAR-FTUs huggingface dataset:
Isolation and Characterization of Multidrug Resistant Enterobacteriaceae in Urine Sample of Patients Suffering from Urinary Tract Infection with Diabetes and Nephropathy

Multidrug-resistant (MDR) organisms are spreading widely and becoming an issue of utmost importance to deal with. In the current study, ten urine samples from diabetic patients suffering from multiple complications, including urinary tract infection (UTI) and nephropathy were investigated. Antibiogram assays of the bacterial isolates from collected samples demonstrated resistance against most of the antibiotics tested. Further studies were conducted to determine the types of resistant bacteria that caused UTI. Analyzing the 16S rDNA sequence and phylogenetic tree, 3 isolates were identified as Escherichia coli, 5 as Klebsiella pneumoniae and the rest 2 as Enterobacter asburiae. The findings of this research indicate the necessity of urgent attention to find an effective alternative drug for treating infections caused by these resistant isolates. Dhaka Univ. J. Pharm. Sci. 20(1): 87-93, 2021 (June)
Türkiye’de Bölgesel Planlamanın Kurumsallaşması: Muğlak Bir Süreci Güncel Kuramlar ile Okumak

Turkiye’de bolge planlama pratigi surecinde icerikler, amaclar ve kurumsal yapilar surekli olarak degisime ugramistir. Olusan karmasik sistem, bolgesel planlarin amaclarini, karar alma mekanizmalarini, surecin mesruiyetini ve bu planlarin genel olarak uygulamadaki basarisini da etkilemistir. Turkiye’de bolgesel planlamada etkili olan karmasik ve degisken kurumsal yapilari degerlendirmek ve kurumsallasma dinamiklerini daha iyi anlamak icin kurumlar ile birlikte, kurumlarin organizasyon mekanizmalari, kurumlar arasi catismalar veya farkli otoriteler arasindaki is birliklerinin evrimi tartismanin merkezine alinarak incelenmelidir. Degisen dinamikler, birden cok kurumu ve kurumlarin iliskilerini iceren sureclerin ickin bir parcasidir. Bu dinamikleri daha iyi anlamak icin temel alinacak kuramsal bir cerceveye ihtiyac vardir. Bu baglamda, Turkiye’de bolgesel planlamadaki kurumsallasmadaki uc ayri evreyi olusturan kirilma noktalarini detayli bir sekilde incelemek, sureci anlamak ve birimler arasindaki iliskileri guncel kuram ve kavramlarla tartismak amaciyla; cok bilesenli yapilarin incelenmesine olanak saglayan asamblaj (assemblage) ve aktor ag kuramlari (actor network) ile kurumsallasma uzerinde demokratik bir catki olusturan agonizm kurami calismanin temel eksenini olusturmaktadir.
Mental health in subsidized housing: Readiness to assist residents with mental health issues in subsidized housing from the perspectives of housing employees

People in subsidized housing are likely to suffer from mental health issues. However, little is known about subsidized housing employees’ readiness to address the residents’ mental health needs. This qualitative study explores the perspectives of housing employees on their readiness to assist subsidized housing residents’ mental health needs. A total of 32 subsidized housing employees participated in five focus groups. Thematic analysis revealed four key themes: prevalence of mental health issues, unexpected role as housing employees, multi-level barriers in assisting residents with mental health needs, and the need for mental health support in subsidized housing. Findings highlight the need for integrated care, including social work services in subsidized housing. Social workers may have various potential roles to serve the mental health needs of subsidized housing residents. Also identified was the need for mental health education and training among subsidized housing employees.
Zynamite® ( Mangifera indica Leaf Extract) and Caffeine Act in a Synergistic Manner on Electrophysiological Parameters of Rat Central Nervous System

Zynamite®, a special extract from Mangifera indica, exerted stimulatory properties on the central nervous system during a pilot study. The question arose if Zynamite® would have a similar action on the central nervous system as caffeine. Two well established animal models were used: a) quantitation of spectral power of field potentials in the freely moving rat and b) induction of long term potentiation (LTP) in the hippocampus slice preparation ex vivo after one week of daily administration. In the presence of 25 mg/kg of Zynamite®, predominantly alpha2 and beta1 spectral frequencies were attenuated in all brain areas during the first hour after administration. Exactly this pattern of frequency changes had been observed in earlier studies with i.p. administration of caffeine. Discriminant analysis confirmed this similarity by projection of Zynamite® and 0.5 mg/kg caffeine into close neighborhood and showing identical colours, which points to a similar mechanism of action in this analysis. In addition, when Zynamite® was combined with very low doses of caffeine synergistic effects were observed. Since alpha2 waves are under the control of dopamine, activation of this neurotransmitter system might be responsible for the stimulating property of Zynamite®. These results are corroborated by the results from the ex vivo study using the hippocampus slice in vitro to follow changes in excitability in the presence of 0.5 mg/kg of caffeine, 25 mg/kg of Zynamite® or their combination in comparison to Placebo after daily administration for one week. Both caffeine and Zynamite® increased LTP. LTP relates to space and time dependent memory. From these studies it is evident that both caffeine and Zynamite® act in similar ways on brain electrical activity, and have potential to improve cognitive function. Bioactive compounds of Zynamite® clearly pass the blood brain barrier to act on the central nervous system. Due to the demonstrated similarity of action, Zynamite® has potential as a CNS-activating nutraceutical that could be used to replace caffeine.
Protective Effects of Fruit Wines against Hydrogen Peroxide—Induced Oxidative Stress in Rat Synaptosomes

This study aimed to evaluate, in vitro, the antioxidative potential of fruit wines produced from berry fruits (i.e., black chokeberry, blueberry, blackberry, and raspberry), cherry, and apple by different technological processes. For this purpose, the activities of antioxidant enzymes (catalase, glutathione peroxidase (GPx), and superoxide dismutase (SOD)) and malondialdehyde (MDA) content as a marker of membrane damage were determined in wine-treated synaptosomes with hydrogen peroxide-induced oxidative stress. All studied wines induced increased antioxidant enzyme activities and decreased MDA levels compared to hydrogen peroxide-treated synaptosomes (i.e., control). The highest SOD activity was observed in synaptosomes treated with blackberry wine (6.81 U/mg), whereas blueberry wine induced the highest catalase and glutathione peroxidase activities (0.058 U/mg and 0.017 U/mg, respectively). Black chokeberry proved to be the best in lipid peroxidation protection with the lowest MDA value (1.42 nmol/mg). Finally, principal component analysis and hierarchical cluster analysis additionally highlighted a higher antioxidant capacity of wines produced from dark-skinned fruits (i.e., blackberry, black chokeberry, and blueberry). The results suggest protective effects of the fruit wines against oxidative damage, and, accordingly, their promising application as functional food.
Antioxidant, α-Glucosidases and α-Amylase Inhibitory Activities of Persicaria odorata

The objects of this study were to determine the effects to reactive oxygen species and antioxidant enzymes levels in HEK-293 cells and inhibition of α-glucosidases and α-amylase enzymes of extracts from Persicaria odorata or phak phaeo. The ethanol extracts from the leaves and the stems of phak phaeo were investigated for their 2,2-diphenyl-1-picryhydrazyl (DPPH) scavenging activities (IC50 were 7.74 ± 0.47 and 7.91 ± 0.43 µg/mL, respectively). Cellular antioxidant effects in human embryonic kidney-293 (HEK-293) cells with these extracts (0.1 mg/mL) also increased the mRNA expressions of manganese superoxide dismutase (Mn-SOD), glutathione peroxidase 1 (GPx-1), catalase and glutathione reductase (GRe). The leaf extract showed the higher efficacies in the induction of the mRNA expressions of Mn-SOD, GPx-1 and GRe while the stem extract exhibited a stronger effect to the induction of catalase. Phak phaeo in vitro inhibitory effects to α-glucosidase enzyme (IC50 values of 9.82 ± 1.64 and 13.99 ± 1.45 µg/mL, respectively and also strong inhibition to α-amylase with IC50 values of 90.66 ± 8.75 and 19.96 ± 5.37 µg/mL, respectively). Lineweaver-Burk plot demonstrated that phak phaeo extracts inhibited α-glucosidase and α- amylase in non-competitive manners. Total phenolic and total flavonoid contents were determined by Folin-Ciocalteu and aluminium chloride methods (the leaf and stem extracts were 22.89 ± 9.16 and 22.27 ± 8.77 g gallic acid equivalent in 100 g extract (g% GAE) and 7.20 ± 3.61 and 4.06 ± 1.73 g quercetin equivalent in 100 g extract (g% QE), respectively). Keywords: Antioxidant enzymes, DPPH, HEK-293, MTT assay, Persicaria odorata, Reactive oxygen species, Total phenolic, Total flavonoid, α-glucosidases, α-amylase
Effects of the Full Coverage Policy of Essential Medicines on Inequality in Medication Adherence: A Longitudinal Study in Taizhou, China

The full coverage policy for essential medicines (FCPEMs) was proposed and implemented in Taizhou city of Zhejiang Province, China, to promote equal access and adherence to medicines. This study aimed to examine the effects of FCPEMs on the income-related inequality in medication adherence among local patients with hypertension or diabetes. We collected electronic health records of patients with hypertension or diabetes of three districts of Taizhou from 2011 to 2016. As the implementation schedule of the FCPEMs varied across districts, we applied a retrospective longitudinal study design and assigned records from 1 year before to 3 years following the implementation of FCPEMs as baseline and follow-up data. We thus generated a dataset with 4-year longitudinal data. The concentration index (CI) and its decomposition method were employed to measure factors contributing to inequality in medication adherence and the role played by FCPEMs. The sample size rose from 264,836 at the baseline to 315,677, 340,512, and 355,676 by each follow-up year, and the proportion of patients taking free medicines rose from 17.6 to 25.0 and 29.8% after FCPEMs implementation. The proportion of patients with high adherence increased from 39.9% at baseline to 51.6, 57.2, and 60.5%, while CI decreased from 0.073 to −0.011, −0.029, and −0.035. The contribution of FCPEMs ranked at 2nd/13, 7th/13, and 2nd/13 after the implementation of FCPEMs. Changes in CI of medication adherence for every 2 years were −0.084, −0.018, and −0.006, and the contribution of FCPEMs was −0.006, 0.006, and 0.007, ranking at 2nd/13, 2nd/13, and 1st/13, respectively. Most changes in CI of medication adherence can be attributed to FCPEMs. The medication adherence of patients with hypertension or diabetes improved after the implementation FCPEMs in Taizhou, although inequality did not improve consistently. In general, FCPEMs could be a protective factor against income-related inequalities in access and adherence to medicines. Future research is needed to investigate the change mechanism and the optimal design of similar interventions.
Effects of Soil Aeration and Fertilization Practices on Alleviating Iron Deficiency Chlorosis in “Huangguan” Pears Grafted onto Quince A in Calcareous Soils

In North China, the high-quality pear cultivar “Huangguan” (Pyrus bretschneideri Rehd. cv), which is grafted onto dwarf quince A (Cydonia oblonga Mill. cv) rootstock and grown in calcareous soil, experiences severe iron (Fe) deficiency; this deficiency greatly constrains tree growth as well as fruit yield and quality. Therefore, we evaluated the effects of six practices for alleviating chlorosis caused by Fe deficiency in “Huangguan” grafted onto quince A (HG-QA). The practices included ridging with landscape fabric mulching as a control, flattening with landscape fabric mulching (FM), ridging without landscape fabric mulching (R), flattening without landscape fabric mulching (F), Fe fertilizer application in soil (SFe), foliar Fe application (FFe), and manure application (M). The results showed that the leaf Fe concentration increased by 356% under FFe, compared to that under the control, but the practice failed to alleviate Fe deficiency chlorosis. In contrast, an increase in leaf Fe concentration and chlorosis alleviation were observed under F. F alleviated chlorosis mainly by increasing the root ferric-chelate reductase activity. These results indicate that Fe uptake and utilization in leaves are independent biochemical processes and soil aeration improvement have positive effect on increasing Fe uptake. M improved both the soil active Fe concentration and leaf Fe utilization. Thus, manure application should be the first choice for alleviating Fe deficiency chlorosis in HG-QA grown in calcareous soils. Combining manure application with other practices that increase Fe uptake would likely be an effective way to address the problem of Fe deficiency chlorosis.
Phosphorus balance in a tropical shallow urban pond in Southeast Brazil: implications for eutrophication management

ABSTRACT A detailed mass balance that evaluates nutrient inputs and outputs is fundamental to determining the most promising strategies to mitigate eutrophication and its undesirable effects. However, such analyses are rare in Brazilian urban ponds where water quality impairment remains a significant issue. We performed a mass balance to identify the main phosphorus (P) sources in a hypereutrophic tropical shallow urban pond. We used the PCLake model to estimate the P loading required to reduce phytoplankton biomass. The water column was considered the primary unit in the model. The P balance was calculated from external inputs, internal inputs from bed sediment to the water column, and outputs from the water column through surface water outflow and to the bed sediments over a full hydrological year. The total P input into the pond water (external and internal) was 35.3 mg m−2 d−1 and the output was 35.2 mg m−2 d−1. The P balance revealed that contributions to the water column from external and internal sources were 82.5% and 17.5%, respectively. Birds were the main contributor to P input (76.0%). The highest P loss from the water column was to the sediment (97.6%). Most of the P leaving the water column to the sediment was retained in the sediment, and part was returned to the water column through internal loading. Measures to reduce eutrophication in this pond should focus on integrated management to decrease both the external and internal P sources by managing birds and avoiding P release from sediment, and to decrease water residence time in the pond.
Media Pembelajaran Buku Pintar (BUPI) Matematika Bagi Anak Berkebutuhan Khusus (ABK)

Anak Berkebutuhan Khusus (ABK) adalah anak yang dalam proses pertumbuhan/ perkembangannya tidak sesuai dengan tumbuh kembang anak pada umumnya baik itu fisik, mental, intelektual, sosial, dan emosional. Pengembangan media pembelajaran Buku Pintar (BUPI) Matematika ini dilatarbelakangi oleh kurangnya media belajar berupa buku 3 Dimensi yang dapat digunakan siswa dalam proses pembelajaran Matematika bagi Anak Berkebutuhan Khusus (ABK). Penelitian ini merupakan kategori penelitian dan pengembangan (R&D), dengan metode pengembangan model Borg & Gall yang dimodifikasi. Buku Pintar (BUPI) Matematika dikembangkan dengan basis kearifan lokal Kota Balikpapan. Hasil validasi menunjukkan bahwa Media pembelajaran Buku Pintar (BUPI) Matematika termasuk dalam kategori Sangat Valid (rata-rata skor 4,69), Sangat Praktis (skor 5), dan Sangat Efektif (rata-rata hasil belajar 80,75).
Modelo de vulnerabilidade em saúde: esclarecimento conceitual na perspectiva do sujeito-social

Resumo Objetivo: Esclarecer a vulnerabilidade em saude a partir da proposicao de um modelo conceitual. Metodo: Aplicou-se o esclarecimento de conceito segundo proposta de Meleis, subsidiado por revisao e por reflexao critica. Selecionaram-se 101 artigos em cinco base de dados por meio da equacao de busca “ vulnerability ” AND “ health ”, cujos achados foram submetidos a analise categorial e de similitude. Essa foi processada no software Iramuteq para identificacao do elemento essencial, conceitos e subconceitos da vulnerabilidade em saude - e posterior construcao de um modelo. Resultados: A partir da revisao e etapas posteriores, a vulnerabilidade em saude foi redefinida, e foi construido um modelo com base na relacao de tres componentes: 1) O sujeito-social, com seus conceitos e subconceitos; 2) A condicao de precariedade e agenciamento; 3) Processos de potencializacao ou fragilizacao da vulnerabilidade em saude. O fenomeno foi descrito, identificando-se o sujeito-social como elemento essencial, e foram conhecidos os principais atributos com as definicoes constitutivas e operacionais, tornando possivel identificar a presenca da vulnerabilidade em saude. Conclusao: O conceito foi esclarecido por meio da construcao de um modelo, fornecendo subsidios a elaboracao de pesquisas na area da saude e ao futuro desenvolvimento de teorias de medio ou longo alcance do fenomeno de interesse.
Formation of linguistic competence of a foreign language teacher (on the example of language) in the system of lifelong learning

The purpose of the academic paper is to establish how effective the introduction of additional courses to advanced training courses is, informing foreign language teachers about world international educational programs in the lifelong professional development system; determining the impact on the knowledge quality of introducing a set of educational activities aimed at the formation of linguistic competence. Empirical, statistical and theoretical methods have been used in the research. In order to diagnose the awareness of teachers about the lifelong learning system and the effectiveness of improving linguistic competence after completing advanced training courses, the methods of questioning, observation, as well as the experimental method have been used. The result of the present research is substantiation that a comprehensive approach to lifelong learning programs contributes to the formation of linguistic competence; it should be permanent and be part of the program of training and retraining of English teachers.
An Analysis of Arches of Foot: A Comparison between Ink Foot Print Method and Custom Made Podoscope Device Method

The present study aimed to assess the validity of the podoscopic images compared with ink footprint methods (comparing the two different methods using the same parameters). Objective: The evaluation of the reliability and accuracy of arch angle (AA) is the purpose of this paper's study. It includes Chippaux-Smirak Index (CSI), Staheli Index (SI), and Arch Index (AI) by comparing footprints obtained from ink footprint and custom-made podoscopic footprints. Methods: Measurements of AA, CSI, SI, and AI are obtained from ink footprints and custom-made podoscope among 416 healthy participants (aged 21 to 65). Accuracy and reliability were calculated for all the footprint indices obtained using the two methods. Minimal detectable change and the Standard error (SE) of measurement were also calculated. Results: SPSS Statistical software (version 20) at 95% confidence interval was used to execute and observe the statistical analysis. Descriptive analysis was used to calculate the Mean and standard deviations (SD). The intrarater reliability of ink footprints and podoscopic footprints were analyzed using Intraclass correlation (IC) executed at 95% confidence intervals (CIs). Reliability of the podoscopic method was interpreted when the values (≥0.75) as excellent, (0.4-0.74) as moderate, and (0-0.39) as poor. Our study reported that AA, CSI, SI, and AI obtained from the ink footprints and podoscope had high intrarater reliability and reproducible. The podoscope was designed in a lightweight manner for transportation purposes and utilized in under-served and rural areas. This custom-made device may be utilized in orthopedics, and it can also be used to collect data and for diagnostic purposes.
Experience-Based Learning Models in Entrepreneurship Courses: An Innovation to Promote Entrepreneurship Based on Local Wisdom

Innovation in learning is necessary to answer the challenges of education in the 21st century. Students who are prepared for the demands of this era will have a mindset to not only seek work but also to create work. Efforts to promote this mindset in students majoring in Development Economics is done by implementing learning innovations in entrepreneurship courses using the experience-based learning model adapted from David Kolbs (1981). This descriptive qualitative research was conducted to examine the innovation of learning using an experience-based learning model. This learning was expected to promote entrepreneurship values in the students based on local wisdom. The data were collected through in-depth interviews with and participant observation of Development Economics students who took the entrepreneurship course, and through the study of documents. Keywords: Experience-Based Learning, Entrepreneurship Values, Local Wisdom
A Proposed Technique for Simultaneously Detecting DDoS and SQL Injection Attacks

As people's reliance on the internet grows, they reveal their data without realizing the implications of a cyberattack. A cyberattack is any form of attack against one or more computers or networks to cause damage. These attacks have the potential to compromise network access, confidentiality, and data integrity. The most popular and powerful attacks to destroy an enterprise, server, or host are distributed denial-ofservice (DDoS) and Structured Query Language injection (SQLi). A distributed denial-of-service (DDoS) attack can freeze an entire website with an intention to ransomware or push viruses. On the other hand, with a successful Structured Query Language injection (SQLi) attack, hackers can access the secret information of a legit user. To deal with DDoS and SQL injection attacks, a variety of techniques have been developed. However, hackers use different techniques to breach security mechanisms, many of which are undetectable by most intrusion detection systems because of their unpredictability. In this paper proposal of a system is given that can detect DDoS and SQL injection attacks simultaneously. Right now, there is no such system that can detect both attacks at the same time. A secure way of browsing the internet and sharing information can be ensured with this system. Webservers will be more secured.
Cryoballoon Atrial Fibrillation Ablation in a Patient with an Atrial Septal Defect Closure Device

Atrial fibrillation (AF) is the most commonly treated arrhythmia in clinical practice and is often found in association with an atrial septal defect (ASD). However, ASD closure rarely confers complete arrhythmia control. A 23-year-old man presented to our center with frequent episodes of palpitations. AF was documented in 12-lead electrocardiography, and echocardiography showed a secundum-type ASD, 14 mm in size, with a significant left-to-right shunt. ASD closure was performed successfully with an ASD occluder device with no residual shunting. During follow-up, the patient experienced several episodes of AF. Thirteen months after the ASD closure, cryoballoon pulmonary vein isolation was done successfully with no complications. During a 12-month follow-up, he had no symptoms or AF recurrences, and echocardiography showed no residual shunting. This study showed that cryoballoon pulmonary vein isolation could be performed successfully without residual shunts in patients with ASD closure devices.