Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing and Prioritising Delay Factors of Prefabricated Concrete Building Projects in China

Prefabricated construction has been widely accepted as an alternative to conventional cast-in-situ construction, given its improved performance. However, prefabricated concrete building projects frequently encounter significant delays. It is, therefore, crucial to identify key factors affecting schedule and explore strategies to minimise the schedule delays for prefabricated concrete building projects. This paper adopts the decision-making trial and evaluation laboratory (DEMATEL) model and analytic network process (ANP) method to quantify the cause-and-effect relationships and prioritise the key delay factors in terms of their importance in the Chinese construction industry. The DEMATEL model evaluates the extent to which each factor impacts other factors. The quantified extents are then converted into a prioritisation matrix through ANP. The delay factors of prefabricated construction projects are selected and categorised based on a literature review and an expert interview. Questionnaires are then implemented to collect the data. The results reveal that the issue of inefficient structural connections for prefabricated components is found to be the most significant factor and most easily affected by other delay factors. This research also suggests prioritising major delay factors, such as ‘lack of communication among participants’ and ‘low productivity’, in the Chinese construction industry during scheduling control. Overall, this research contributes an assessment framework for decision making in the scheduling management of prefabricated construction.
Oridonin Attenuates Burkholderia cenocepacia Virulence by Suppressing Quorum-Sensing Signaling

Burkholderia cenocepacia is an important human opportunistic pathogen that can cause life-threatening infections in susceptible individuals. It employs quorum-sensing (QS) systems to regulate biological functions and virulence. ABSTRACT Burkholderia cenocepacia is a human opportunistic pathogen that mostly employs two types of quorum-sensing (QS) systems to regulate its various biological functions and pathogenicity: the cis-2-dodecenoic acid (BDSF) system and the N-acyl homoserine lactone (AHL) system. In this study, we reported that oridonin, which was screened from a collection of natural products, disrupted important B. cenocepacia phenotypes, including motility, biofilm formation, protease production, and virulence. Genetic and biochemical analyses showed that oridonin inhibited the production of BDSF and AHL signals by decreasing the expression of their synthase-encoding genes. Furthermore, we revealed that oridonin directly binds to the regulator RqpR of the two-component system RqpSR that dominates the above-mentioned QS systems to inhibit the expression of the BDSF and AHL signal synthase-encoding genes. Oridonin also binds to the transcriptional regulator CepR of the cep AHL system to inhibit its binding to the promoter of bclACB. These findings suggest that oridonin could potentially be developed as a new QS inhibitor against pathogenic B. cenocepacia. IMPORTANCE Burkholderia cenocepacia is an important human opportunistic pathogen that can cause life-threatening infections in susceptible individuals. It employs quorum-sensing (QS) systems to regulate biological functions and virulence. In this study, we have identified a lead compound, oridonin, that is capable of interfering with B. cenocepacia QS signaling and physiology. We demonstrate that oridonin suppressed cis-2-dodecenoic acid (BDSF) and N-acyl homoserine lactone (AHL) signal production and attenuated virulence in B. cenocepacia. Oridonin also impaired QS-regulated phenotypes in various Burkholderia species. These results suggest that oridonin could interfere with QS signaling in many Burkholderia species and might be developed as a new antibacterial agent.
Association of Self-reflection With Cognition and Brain Health in Cognitively Unimpaired Older Adults

Background and Objectives Self-reflection (the active evaluation of ones thoughts, feelings, and behaviors) can confer protection against adverse health outcomes. Its effect on markers sensitive to Alzheimer disease (AD), however, is unknown. The primary objective of this cross-sectional study was to examine the association between self-reflection and AD-sensitive markers. Methods This study used baseline data from cognitively unimpaired older adults enrolled in the Age-Well clinical trial and older adults with subjective cognitive decline from the SCD-Well clinical trial. In both cohorts, self-reflection was measured via the reflective pondering subscale of the Rumination Response Scale, global cognition assessed via the Preclinical Alzheimer's Cognitive Composite 5, and a modified late-life Lifestyle-for-Brain-Health (LIBRA) index computed to assess health and lifestyle factors. In Age-Well, glucose metabolism and amyloid deposition were quantified in AD-sensitive gray matter regions via fluorodeoxyglucose- and AV45-PET scans, respectively. Associations between self-reflection and AD-sensitive markers (global cognition, glucose metabolism, and amyloid deposition) were assessed via unadjusted and adjusted regressions. Furthermore, we explored whether associations were independent of health and lifestyle factors. To control for multiple comparisons in Age-Well, false discovery rate–corrected p values (pFDR) are reported. Results A total of 134 (mean age 69.3 ± 3.8 years, 61.9% women) Age-Well and 125 (mean age 72.6 ± 6.9 years, 65.6% women) SCD-Well participants were included. Across unadjusted and adjusted analyses, self-reflection was associated with better global cognition in both cohorts (Age-Well: adjusted-β = 0.22, 95% CI 0.05–0.40, pFDR = 0.041; SCD-Well: adjusted-β = 0.18, 95% CI 0.03–0.33, p = 0.023) and with higher glucose metabolism in Age-Well after adjustment for all covariates (adjusted-β = 0.29, 95% CI 0.03–0.55, pFDR = 0.041). Associations remained following additional adjustment for LIBRA but did not survive false discovery rate (FDR) correction. Self-reflection was not associated with amyloid deposition (adjusted-β = 0.13, 95% CI −0.07 to 0.34, pFDR = 0.189). Discussion Self-reflection was associated with better global cognition in 2 independent cohorts and with higher glucose metabolism after adjustment for covariates. There was weak evidence that relationships were independent from health and lifestyle behaviors. Longitudinal and experimental studies are warranted to elucidate whether self-reflection helps preserve cognition and glucose metabolism or whether reduced capacity to self-reflect is a harbinger of cognitive decline and glucose hypometabolism. Trial Registration Information Age-Well: NCT02977819; SCD-Well: NCT03005652.
Hierarchy of contamination control in the fire service: Review of exposure control options to reduce cancer risk

Abstract The international fire service community is actively engaged in a wide range of activities focused on development, testing, and implementation of effective approaches to reduce exposure to contaminants and the related cancer risk. However, these activities are often viewed independent of each other and in the absence of the larger overall effort of occupational health risk mitigation. This narrative review synthesizes the current research on fire service contamination control in the context of the National Institute for Occupational Safety and Health (NIOSH) Hierarchy of Controls, a framework that supports decision making around implementing feasible and effective control solutions in occupational settings. Using this approach, we identify evidence-based measures that have been investigated and that can be implemented to protect firefighters during an emergency response, in the fire apparatus and at the fire station, and identify several knowledge gaps that remain. While a great deal of research and development has been focused on improving personal protective equipment for the various risks faced by the fire service, these measures are considered less effective. Administrative and engineering controls that can be used during and after the firefight have also received increased research interest in recent years. However, less research and development have been focused on higher level control measures such as engineering, substitution, and elimination, which may be the most effective, but are challenging to implement. A comprehensive approach that considers each level of control and how it can be implemented, and that is mindful of the need to balance contamination risk reduction against the fire service mission to save lives and protect property, is likely to be the most effective.
Patient perspectives of successful adalimumab biosimilar transitioning in Crohn’s disease: an interview study

Objectives Transition from originator biological medicines to their biosimilar equivalents is now part of routine clinical practice, but there is little understanding of patient experiences, which influence adherence and overall satisfaction with care. Understanding this will help ensure future switches adequately address patients’ concerns and expectations leading to better outcomes for all stakeholders. Method 35 patients participating in a clinical trial including an open-label transition event from originator to biosimilar adalimumab, mimicking what would be encountered in a real-world setting, took part in semi-structured interviews exploring their experience of biosimilar transition. Results Opinions expressed were often heterogeneous, but common experiences and themes were identified. Five themes were identified following thematic analysis. (1) Understanding and awareness of biosimilars: prior awareness of biosimilars and knowledge of the biosimilar concept was low, indicating a disparity between healthcare professionals and patients. (2) Motivation to undertake transition: patients accept a biosimilar transition to minimise drug expenditure. (3) Initial concerns: before undertaking biosimilar transition away from the brand they had experienced, anticipated loss of efficacy and adverse effects from the biosimilar were common concerns for patients. (4) Reassuring factors: trust in the healthcare team is critical to patient acceptance of biosimilars. Important reassurances include a point of contact, education about biosimilars and monitoring. (5) Experiences during the transition: on reflection, participants described consistent efficacy and tolerability (although 22 participants specifically mentioned injection pain) following brand transition. Conclusion The majority of patients felt comfortable with future transition to another adalimumab biosimilar. Injection experience was an important component of patient satisfaction.
Mental workload variations during different cognitive office tasks with social media interruptions

Abstract Interruption at work by social media (SM) is a pervasive phenomenon. This study investigated the impact of SM interruptions and task cognitive levels on mental workload (MWL) and physiological indexes. Each subject performed six simulated computer tasks differentiated by two factors: task cognitive level and performing condition. MWL was reflected through three categories of data: perceived mental workload, physiological indexes, and primary task performance. The results revealed significant effects of SM interruptions on heart rate, low-frequency/high-frequency (LF/HF) ratio, and skin conductance. ANOVA results showed there were main effects of task cognitive level on LF/HF and skin conductance. These effects during interrupted tasks were more profound. In addition, participants experienced higher MWL and recorded lower primary task performance in the knowledge-based task than the rule- and skill-based tasks. Our findings can guide managers and employees regarding appropriate use of SM in the workplace and better managing interruption and workload. Practitioner Summary: Office workers suffer from increased overall mental workload due to unpredictable interruptions while working. This study shows that participants’ mental workload increased when receiving SM interruptions, which was more profound during complex tasks. This highlights the importance of SM interruptions management for employees’ health, performance, and mobile application developers. Abbreviations: ANOVA: analysis of variance; DSSQ: dundee stress state questionnaire; ECG: electrocardiographic; EDA: electrodermal activity; EEG: electroencephalographic; HPA: hypothalamus-pituitaryadrenocortical; HR: heart rate; HRV: heart rate variability; LF/HF: low frequency/high frequency; MSDs: musculoskeletal disorders; MWL: mental workload; NN: normal to normal; RMS: root means square; RR: time duration between two successive R peaks; RT: response time; SC: skin conductance; SDNN: standard deviation of normal to normal; SM: social media; TCL: task cognitive level; TPC: task performing condition; WMC: working memory capacity
Advance Care Planning Experiences Among Sexual and Gender Minority People

Key Points Question What are the barriers and facilitators to advance care planning discussions for sexual and gender minority (SGM) people? Findings In this qualitative study of 201 SGM people and 402 non-SGM people, survey participants reported experiences of discrimination in health care, and interview participants described concerns regarding whether their preferences would be supported. Meaning The findings suggest that discrimination in the health care system is an important barrier to advance care planning for SGM people.
Cancer Medicines: What Is Essential and Affordable in India?

PURPOSE The WHO essential medicines list (EML) guides selection of drugs for national formularies. Here, we evaluate which medicines are considered highest priority by Indian oncologists and the extent to which they are available in routine practice. METHODS This is a secondary analysis of an electronic survey developed by the WHO EML Cancer Medicine Working Group. The survey was distributed globally using a hierarchical snowball method to physicians who prescribe systemic anticancer therapy. The survey captured the 10 medicines oncologists considered highest priority for population health and their availability in routine practice. RESULTS The global study cohort included 948 respondents from 82 countries; 98 were from India and 67 were from other low- and middle-income countries. Compared with other low- and middle-income countries, the Indian cohort was more likely to be medical oncologist (70% v 31%, P < .001) and work exclusively in the private health system (52% v 17%, P < .001). 14/20 most commonly selected medicines were conventional cytotoxic drugs. Universal access to these medicines was reported by a minority of oncologists; risks of significant out-of-pocket expenditures for each medicine were reported by 19%-58% of oncologists. Risk of catastrophic expenditure was reported by 58%-67% of oncologists for rituximab and trastuzumab. Risks of financial toxicity were substantially higher within the private health system compared with the public system. CONCLUSION Most high-priority cancer medicines identified by Indian oncologists are generic chemotherapy agents that provide substantial improvements in survival and are already included in WHO EML. Access to these treatments remains limited by major financial burdens experienced by patients. This is particularly acute within the private health system. Strategies are urgently needed to ensure that high-quality cancer care is affordable and accessible to all patients in India.
Mandibular morphometry applied to local anaesthetic blockage in the capybara (Hydrochoerus hydrochaeris)

Capybaras have been victims of collisions against vehicles, which can result in fractures of the teeth and mandible. Then, a local anaesthetic block of the inferior alveolar and mental nerves is important for performing therapeutic procedures in the oral cavity of these rodents. Thus, the aim of this study was to describe the mandibular morphometry of the capybara with emphasis on the establishment of anatomic references for anaesthetic block of the inferior alveolar and mental nerves. For this, mandibles from eight young and adult capybaras were used. Radiography and morphometry of the capybara hemimandible were performed. The mandibular foramen had a dorsoventral diameter of 2.1 mm in young and 2.2 mm in adult capybaras, and it was situated ventrally to the third molar tooth. For extraoral block of the inferior alveolar nerve, the needle should be introduced obliquely 63.5 and 77.4 mm from the angular process in young and adult capybaras, respectively. In another extraoral approach, the needle should be introduced perpendicularly 20.8 mm in young and 26.3 mm in adult animals from the ventral margin of the capybara mandible. For blocking only the mental nerve, the needle should be inserted perpendicularly from the interalveolar margin, 10.7 and 11.5 mm in the young and adult capybaras, respectively. The findings of this study suggest that the age group should be taken into account when performing the anaesthetic block of the inferior alveolar and mental nerves in capybaras.
Sleep and the Young Athlete

Context: Sleep plays a vital role in cognitive and physical performance. Teenage athletes (ages 13-19 years) are considered especially at risk for disordered sleep and associated negative cognitive, physical, and psychosomatic effects. However, there is a paucity of evidence-based recommendations to promote sleep quality and quantity in athletes who fall within this age range. We performed a review of the literature to reveal evidence-based findings and recommendations to help sports instructors, athletic trainers, physical therapists, physicians, and other team members caring for young athletes provide guidance on sleep optimization for peak sports performance and injury risk reduction. Methods: PubMed, Scopus, and Cochrane CENTRAL were searched on May 11, 2016, and then again on September 1, 2020, for relevant articles published to date. Study Design: Narrative review. Level of Evidence: Level 4. Results: Few studies exist on the effects disordered sleep may have on teenage athletes. By optimizing sleep patterns in young athletes during training and competitions, physical and mental performance, and overall well-being, may be optimized. Adequate sleep has been shown to improve the performance of athletes, although further studies are needed. Conclusion: Twenty-five percent of total sleep time should be deep sleep, with a recommended sleep time of 8 to 9 hours for most young athletes. Screen and television use during athletes’ bedtime should be minimized to improve sleep quality and quantity. For young athletes who travel, jet lag can be minimized by allowing 1 day per time zone crossed for adjustment, limiting caffeine intake, planning meals and onboard sleeping to coincide with destination schedules, timing arrivals in the morning whenever possible, and using noise-canceling headphones and eyeshades. Strength-of-Recommendation Taxonomy (SORT): B.
Achieving Zero Switching Loss in Silicon Carbide MOSFET

Due to the unipolar conduction mechanism, the switching loss of silicon carbide (SiC) metal-oxide-semiconductor field-effect transistor (mosfet) is reduced significantly when compared with silicon insulated gate bipolar transistor (IGBT). This enables the use of SiC mosfet in high-frequency application. However, the switching loss could still thermally limit the upper limit of the switching frequency. Further reduction of switching loss of SiC mosfet, therefore, remains an open challenge for higher frequency applications. Based on the in-depth revelation of device physics of the switching process, accurate switching loss model is established which highlights the dependence of the switching loss on the gate driving condition. With extreme fast gate driving condition, several loss limitations can be established. The minimum turn-on loss is the energy stored in the output capacitance and the minimum turn-off loss can approach zero or the so-called zero turn-off loss (ZTL). Furthermore, zero switching loss (ZSL) is achieved when utilizing zero-voltage switching turn-on and ZTL turn-off condition. With ZSL, the upper limit of the switching frequency is no long thermally limited which is verified by co-package experimental demonstration. We believe the trailblazing concepts of SiC mosfet switching loss will provide guiding principles for device innovation, package optimization, gate driver improvement, and current possible solutions toward higher frequency applications.
Trends in the Beijing cesarean section rate and reasons for the fluctuations

To the Editor : Cesarean section (CS) resolves dystocia and serious pregnancy-related complications but also has adverse outcomes such as long recovery time, uterine rupture, and dangerous placenta previa in future preg-nancies. The increase in cesarean section rates (CSRs) worldwide has drawn the attention of international scholars. [1] In China, the CSR has increased since the 1980s, reaching 54.47% in 2011. [2] This present study sought to provide updated information on the changes in the CSR, and reasons for the changes in Beijing from 2012 to 2017 as a guide for obstetricians and to develop strategies to reduce the CSR.
Pain Location and Exacerbating Activities Associated with Treatment Success Following Basivertebral Nerve Ablation: An Aggregated Cohort Study of Multicenter Prospective Clinical Trial Data

Abstract Objective Develop pain location “maps” and investigate the relationship between low back pain (LBP)-exacerbating activities and treatment response to basivertebral nerve radiofrequency ablation (BVN RFA) in patients with clinically suspected vertebral endplate pain (VEP). Design Aggregated cohort study of 296 patients treated with BVN RFA at 33 centers in three prospective trials. Methods Participant demographics, pain diagrams, and LBP-exacerbating activities were analyzed for predictors using stepwise logistic regression. Treatment success definitions were: (1) ≥50% LBP visual analog scale (VAS), (2) ≥15-point Oswestry Disability Index (ODI), and (3) ≥50% VAS or ≥15-point ODI improvements at 3 months post-BVN RFA. Results Midline LBP correlated with BVN RFA treatment success in individuals with clinically-suspected VEP. Duration of pain ≥5 years (OR 2.366), lack of epidural steroid injection within 6 months before BVN RFA (OR 1.800), lack of baseline opioid use (OR 1.965), LBP exacerbation with activity (OR 2.099), and a lack of LBP with spinal extension (OR 1.845) were factors associated with increased odds of treatment success. Regressions areas under the curve (AUCs) were under 70%, indicative of low predictive value. Conclusions This study demonstrates that midline LBP correlates with BVN RFA treatment success in individuals with VEP. While none of the regression models demonstrated strong predictive value, the pain location and exacerbating factors identified in this analysis may aid clinicians in identifying patients where VEP should be more strongly suspected. The use of objective imaging biomarkers (Type 1 and/or 2 Modic changes) and a correlating presentation of anterior spinal element pain remain the most useful patient selection factors for BVN RFA.