Miracle-dz/UniFAR-FTUs huggingface dataset:
Intraoperative subcortical mapping of a language-associated deep frontal tract connecting the superior frontal gyrus to Broca’s area in the dominant hemisphere of patients with glioma

obJect The deep frontal pathway connecting the superior frontal gyrus to Broca’s area, recently named the frontal aslant tract (FAT), is assumed to be associated with language functions, especially speech initiation and spontaneity. In - jury to the deep frontal lobe is known to cause aphasia that mimics the aphasia caused by damage to the supplementary motor area. Although fiber dissection and tractography have revealed the existence of the tract, little is known about its function. The aim of this study was to determine the function of the FAT via electrical stimulation in patients with glioma who underwent awake surgery. methods The authors analyzed the data from subcortical mapping with electrical stimulation in 5 consecutive cases (3 males and 2 females, age range 40–54 years) with gliomas in the left frontal lobe. Diffusion tensor imaging (DTI) and tractography of the FAT were performed in all cases. A navigation system and intraoperative MRI were used in all cases. During the awake phase of the surgery, cortical mapping was performed to find the precentral gyrus and Broca’s area, followed by tumor resection. After the cortical layer was removed, subcortical mapping was performed to assess language-associated fibers in the white matter. results In all 5 cases, positive responses were obtained at the stimulation sites in the subcortical area adjacent to the FAT, which was visualized by the navigation system. Speech arrest was observed in 4 cases, and remarkably slow speech and conversation was observed in 1 case. The location of these sites was also determined on intraoperative MR images and estimated on preoperative MR images with DTI tractography, confirming the spatial relationships among the stimulation sites and white matter tracts. Tumor removal was successfully performed without damage to this tract, and language function did not deteriorate in any of the cases postoperatively. coNclusioNs
Evaluating the Pharmacoeconomic Implications of Cancer Drug Therapies: A Comprehensive Analysis

-The field of cancer medication therapy has been significantly transformed by the progress made in personalised medicine, targeted therapies, and immunotherapies. However, the considerable expenses associated with these advancements have given rise to apprehensions regarding their pharmacoeconomic implications. This review offers a thorough examination of the pharmacoeconomic implications associated with cancer drug therapies. It encompasses various factors such as cost-effectiveness, global accessibility and affordability, financial burden on patients, economic consequences of adverse events, the significance of real-world evidence and comparative effectiveness research, as well as the influence of generic drugs and drug shortages. The results of our study indicate that although novel cancer medication therapies may have higher initial expenses, their ability to enhance clinical outcomes and improve health-related quality of life may provide a valid rationale for these expenditures.
Review of Public Administration and Management

This paper was carried out because of the gap which existed between the locus of control and self concept as determinants of database information or electronic database in private higher institutions. The sample statistical tools used were correlation and regression. The study employ random sampling to select 2086 academic staff (lecturers) from fourteen higher institutions while 3308 population size were used out of twenty one private institutions. The data generated through with the instrument of questionnaire. Analysis of the findings was carried out by employ frequency, means and percentage. Analysis of finding shows that self concept (r = 883**, p<.05) while locus of control (r= .969**, p<.05) which was highly important and related ti the use of online and database information sources. The study found that self-concept and locus of control relatively contribution were ninety-nine (99%) to the use of online information. It was recommended that management of this higher institution should provide current internet facilities to enhance lecturers’ standard for effective communication to improve students’ careers
Gassing Tendency of Natural Ester Based Transformer Oils: Low Ethane Generation in Stray Gassing Behavior

 Abstract — Mineral oils of naphthenic and paraffinic type are in use as insulating liquids in the transformer applications to protect solid insulation from moisture and ensures effective heat transfer/cooling. The performance of these type of oils have been proven in the field over many decades and the condition monitoring and diagnosis of transformer performance have been successfully monitored through oil properties and dissolved gas analysis methods successfully. Different types of gases can represent various types of faults that may occur due to faulty components or unfavorable operating conditions. A large amount of database has been generated in the industry for dissolved gas analysis in mineral oil-based transformer oils, and various models have been developed to predict faults and analyze data. Additionally, oil specifications and standards have been updated to include stray gassing limits that cover low-temperature faults. This modification has become an effective preventative maintenance tool that can help greatly in understanding the reasons for breakdowns of electrical insulating materials and related components. Natural esters have seen a rise in popularity in recent years due to their "green" credentials. Some of its benefits include biodegradability, a higher fire point, improvement in load capability of transformer and improved solid insulation life than mineral oils. However, the stray gassing test shows that hydrogen and hydrocarbons like methane (CH 4 ) and ethane (C 2 H 6 ) show very high values which are much higher than the limits of mineral oil standards. Though the standards for these types of esters are yet to be evolved, the higher values of hydrocarbon gases that are available in the market is of concern which might be interpreted as a fault in transformer operation. The current paper focuses on developing a class of natural esters with low levels of stray gassing by American Society for Testing and Materials (ASTM) and International Electric Council (IEC) methods much lower values compared to the natural ester-based products reported in the literature. The experimental results of products are explained.
coloniza-Bifidobacterium infantis and 2′-fucosyllactose supplementation in early life may have potential long-term benefits on gut microbiota, intestinal development, and immune function in mice

The health benefits of nutritional interventions targeting the gut microbiota in early life are transient, such as probiotics, prebiotics, and synbiotics. This study sought to determine whether supplementation with Bifidobacterium infantis 79 (B79), 2 ′ -fucosyl- lactose (2 ′ -FL), or both (B79+2 ′ FL) would lead to persistent health benefits in neonatal BALB/c mice. We found that at postnatal day (PND) 21, Ki67 and MUC2 expression increased, while total serum IgE content decreased in the B79, 2 ′ -FL, and B79+2 ′ -FL groups. The gut microbiota structure and composition altered as well. The levels of propionic acid, sIgA, and IL-10 increased in the 2 ′ -FL group. Moreover, butyric acid content increased, while IL-6, IL-12p40, and tumor necrosis factor-α decreased in the B79+2 ′ -FL group. At PND 56, Ki67 and MUC2 expression increased, whereas the gut microbiota remained altered in all 3 groups. The serum total IgG level increased only in the B79+2 ′ -FL group. In conclusion, our study suggests that early-life supplementation with B79, 2 ′ -FL, or their combination persistently alters the gut microbiome and promotes intestinal development; the immunomodulatory capacity of B79 and 2'-FL occurs during weaning, and their combination may persist into adulthood.
IMPLICATIONS OF TELECOMMUNICATION PROGRAM ON SERVICE QUALITY IN EDO STATE, NIGERIA, FROM 2005 TO 2021

This study investigated mobile telecommunication policy and service delivery in Edo state, Nigeria, from 2005 to 2021. Two objectives were identified in the course of the study; two research questions were raised and two hypotheses were put forward for analysis in the study. A survey research was designed and stratified sampling procedure was used in selecting the sample for the study. Structured questionnaire was the instrument used for primary data while library materials, textbook and other relevant materials were also used to source the secondary data. The population of the study consist of staff of MTN and residents of Benin. Tara Yamane formula was used to determine the simple size of 249 from a population of 1,782,000. Findings from the study indicated that government policies have a relationship with mobile telecommunication service quality in Edo state, Nigeria. it was also discovered that government regulations have no relationship with mobile telecommunication service delivery in Edo state, Nigeria. In view of the foregoing, it was suggested among others that government should ensure strict compliance with policy and regulatory directives issued to see to its effective implementation by mobile telecommunication operators in the country.
Hawai‘i Journal of Health & Social Welfare

Depression and anxiety have been associated with cigarette use among young people. Higher impulsivity has also been associated with increased smoking behavior. However, relatively less is known about the associations between depression, anxiety, impulsivity and e-cigarette use and how these associations compare with the associations between depression, anxiety, impulsivity and cigarette smoking. In addition, little is known about how impulsivity influences the relationships between depression, anxiety, cigarette, and e-cigarette use. This study tested the hypothesis that higher depression and anxiety symptoms are associated with higher e-cigarette use and cigarette smoking in a similar way, and that these associations would be stronger among those with higher impulsivity. A sample of 2,622 young adults (18-25 year olds; 54% women) enrolled in 4-year and 2-year colleges in Hawai‘i participated in a cross-sectional survey. Approximately 68% of the sample reported no use of either e-cigarettes or cigarettes, 13% reported only e-cigarette use, 9% reported only cigarette smoking, and 11% reported use of both. The study found that higher depressive and anxiety symptoms and higher impulsivity were significantly associated with current cigarette and e-cigarette use. For example, one unit increases in depression, anxiety, and impulsivity were associated with 34%, 17%, and 38% increased odds of e-cigarette use versus non-use, respectively. Impulsivity was found to significantly moderate the association between higher anxiety and higher cigarette smoking, such that the association was stronger among those with higher impulsivity. Impulsivity was not found to moderate any other association. Results suggest that tobacco product use prevention education should target children and young adults with higher internalizing symptoms, with particular attention to those who show higher impulsivity.
[Circadian variations in proinflammatory cytokine concentrations in acute myocardial infarction].

INTRODUCTION AND OBJECTIVES The concentration of certain proinflammatory cytokines has been found to be elevated in patients with acute coronary syndrome. Many studies have shown that coronary ischemic accidents do not show a uniform distribution throughout the day, but instead exhibit rhythmic variations. The objective of this study is to determine whether there is a circadian pattern of variation in the concentrations of proinflammatory cytokines in patients with acute myocardial infarction. PATIENTS AND METHOD The sample included 40 patients with acute myocardial infarction and 40 controls. Levels of interleukin 6 and 1 beta were determined in the first 24 hours after the acute coronary ischemic episode. Blood samples were extracted at 3:00 a.m. (period of darkness) and at 10:00 a.m. (period of daylight). RESULTS Both groups were similar in age, sex distribution, and coronary risk factors. Interleukin 6 levels showed a significant variation between daylight and nighttime concentrations in patients with acute myocardial infarction and controls (41.93 5.90/100.39 13.60 vs 25.76 4.45/52.67 7.73 pg/ml). However, interleukin 6 concentrations were higher in the acute myocardial infarction group than in the control group. Interleukin 1 beta concentrations did not vary between daylight and darkness. CONCLUSIONS In both the control group and acute myocardial infarction group, interleukin 6 concentrations varied between daylight and darkness. Patients with acute myocardial infarction shown a higher concentration of interleukin 6 secondary to the physiological response to tissue damage. Circadian variations can affect the measurements obtained for different physiological and biochemical parameters.
INT2: Interactive Trajectory Prediction at Intersections

Motion forecasting is an important component in autonomous driving systems. One of the most challenging problems in motion forecasting is interactive trajectory prediction, whose goal is to jointly forecasts the future trajectories of interacting agents. To this end, we present a large-scale interactive trajectory prediction dataset named INT2 for INTeractive trajectory prediction at INTersections. INT2 includes 612,000 scenes, each lasting 1 minute, containing up to 10,200 hours of data. The agent trajectories are auto-labeled by a high-performance offline temporal detection and fusion algorithm, whose quality is further inspected by human judges. Vectorized semantic maps and traffic light information are also included in INT2. Additionally, the dataset poses an interesting domain mismatch challenge. For each intersection, we treat rush-hour and non-rush-hour segments as different domains. We benchmark the best open-sourced interactive trajectory prediction method on INT2 and Waymo Open Motion, under in-domain and cross-domain settings. The dataset, code and models are publicly available at https://github.com/AIRDISCOVER/INT2.
Some Experiments and Issues to Exploit Multicore Parallelism in a Distributed-Memory Parallel Sparse Direct Solver

: MUMPS is a parallel sparse direct solver, using message passing (MPI) for parallelism. In this report we experiment how thread parallelism can help taking advantage of recent multicore architectures. The work done consists in testing multithreaded BLAS libraries and inserting OpenMP di-rectives in the routines revealed to be costly by proﬁling, with the objective to avoid any deep restructuring or rewriting of the code. We report on various aspects of this work, present some of the beneﬁts and diﬃculties, and show that 4 threads per MPI process is generally a good compromise. We then discuss various issues that appear to be critical in a mixed MPI-OpenMP environment.
Comparative Study Between Corpus Luteum Changes in Normal Comparative Study Between Corpus Luteum Changes in Normal Pregnancy and Threatened Abortion Using Transvaginal Color Pregnancy and Threatened Abortion Using Transvaginal Color Doppler Sonography Doppler Sonography

Background: Threatened abortion constitutes 15–20% of pregnancies and is one of the commonest gynecological emergencies. Transvaginal sonography seems more promising in evaluating the features of the Corpus luteum and therefor can predict pregnancy outcome. Aim of work: The aim of our study is to compare the clinical and sonographic characteristics between women with threatened abortion compared to those with normal pregnancy using transvaginal color Doppler ultrasonography, to predict pregnancy outcome in first trimesteric threatened abortion pregnancies. Patients and methods: This study a prospective cohort observational, was carried out on 200 pregnant women (divided into two groups). Group I: 100 pregnant women with normal pregnancy. Group II: 100 pregnant women with threatened abortion, in Al-Galaa Maternity Hospital. Results: As regards the site, size and growth rate of C.L. , there was no significant difference between normal pregnancy and threatened abortion. By T.V. S, 4 different patterns of C.L. could be identified: hypoechoic, thick walled cyst, complex cyst and simple cyst; and none of them was predictive of pregnancy outcome in threatened abortion. As regards resistance index of luteal blood flow, only resistance index increases significantly if abortion occurs; and so far, Doppler studies could serve as a predictive diagnostic tool in assessing C.L. function. Conclusion: There is significant increase in resistance index of corpus luteum blood flow in cases of threatened abortion which ended as missed, incomplete or complete abortion compared to the continued or control cases.
Crisis Management as Strategic Coping

To which extent bureaucracies are inflexible and strategic planning is incompatible with emerging coping strategies are empirical questions. Based on a longitudinal case study of neo-Weberian state type local governments responses to different types of crises, this article argues that bureaucracies are at the heart of local coping strategies and indeed capable of adjusting to changing environments. They demonstrate capacious variation. The study adds the strategic perspective, falsifies the theoretical claims of the New Public Government (NPG) and confirms the ones of the neo-Weberian state (NWS). Strategic planning is far from dead. Crisis management was left to the CEOs and the administrative system, and it was top-down driven. Strategic plans had a life alongside strategic manoeuvring, and a variety in the hybrid mix of governance paradigms - as well as clear patterns of isomorphic structures - are interpreted as functional and symbolic adjustments.
Growth Differentiation Factor-9 and Bone Morphogenic Protein-15 as Predictors of Oocyte and Embryo Quality in Sub-Fertile Women Undergoing Assisted Reproduction

Background: Oocyte-secreted proteins can provide evidence about folliculogenesis and express the quality of oocytes and the quality of the resulting embryos. Objective: To evaluate the ability of serum and follicular fluid growth differentiation factor 9 (GDF-9) and bone morphogenic protein 15 (BMP-15) in predicting oocyte and embryonic quality, subsequent embryonic development and pregnancy rate. Methods: A prospective cohort study involved 114 sub-fertile females who sought intracytoplasmic sperm injection (ICSI) to treat infertility. They are 18 to 43 years old, and their body mass index (BMI) ranged from 19 to 30 kg/m2. Before ICSI, there was controlled ovarian stimulation and pituitary downregulation. Following oocyte collection, microscopic assessment of oocyte and embryo quality was done. Serum was collected on the second day of the menstrual cycle, while follicular fluid was collected on the day of oocyte collection, and GDF-9 and BMP-15 were measured in both using a special kit by ELIZA. Results: The pregnancy rate was 35.2%. Follicular fluid GDF-9, serum and follicular fluid BMP-15 showed significant positive correlations with the total number of mature oocytes. Follicular fluid BMP-15 showed significant positive correlations with total oocyte count and fertilization rate. Follicular fluid BMP-15 showed a significant and positive correlation to the total embryo quality count. Conclusions: Serum and follicular fluid BMP-15 are good predictors of oocyte number and quality but have no role in predicting embryonic quality, blastocyst count or pregnancy rate.
The prognostic value of zonal origin in clinically localized prostate cancer: a systematic review and meta-analysis

Introduction Correlation between zonal origin of clinically localized prostate cancer (PC) and biochemical recurrence (BCR) after treatment is still controversial. Methods We performed a meta-analysis of published articles to investigate the prognostic value of zonal origin in clinically localized PC. Literature was searched from Medline, Embase, Scopus, and Web of Science, from inception to Nov 1st, 2022. The risk of BCR was compared between PC originating from transition zone with peripheral zone. Relative risk (RR) was pooled in a random-effects model. Subgroup analysis and meta-regression were conducted to assess the source of heterogeneity. Results 16 cohorts and 19,365 patients were included. PC originating from transition zone was associated with a lower risk of BCR (RR, 0.79, 95%CI; 0.69-0.92, I2, 76.8%). The association was consistent in studies with median follow-up time ≥60 months (RR, 0.65; 95%CI, 0.48 to 0.88, I2 56.8%), studies with NOS score ≥8 (RR, 0.70; 95%CI, 0.62 to 0.80, I2 32.4%), and studies using multivariate regression model (RR, 0.57; 95%CI, 0.48 to 0.69, I2 23%). Discussion This meta-analysis supported that transition zone origin was an independent prognostic factor of a better biochemical result in clinically localized prostate cancer after treatment. Systematic review registration 10.37766/inplasy2023.11. 0100, identifier INPLASY2023110100.
The effects of pomegranate consumption on obesity indices in adults: A systematic review and meta‐analysis

Abstract Evidence supports the potential application of polyphenols as agents against obesity. Pomegranate is one of the fruits that possess a high content of polyphenols. This systematic review and meta‐analysis of randomized controlled trials (RCTs) sought to evaluate the effects of pomegranate consumption on obesity indices, including body mass index (BMI), body weight, waist circumference (WC), fat mass (FM), body fat percentage (BFP), and fat‐free mass (FFM) in adults. Relevant RCTs were obtained by searching databases, including PubMed, SCOPUS, and Web of Science, up to May 2023. Heterogeneity tests of the included trials were performed using the I 2 statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as the weighted mean difference with a 95% confidence interval. Pooled analysis of 28 trials revealed that pomegranate consumption led to a significant reduction in body weight (WMD: −1.97, 95% CI: −2.91, −1.03, p < .05), and a significant decrease in BMI (WMD: −0.48, 95% CI: −0.76, −0.20, p < .05) in comparison with the control group. However, there were no significant effects on WC, FM, FFM, and BFP in comparison with the control group. Pomegranate consumption may yield a beneficial effect on body weight and BMI in adults. However, there were no significant effects on WC, FM, FFM, and BFP, by pomegranate consumption. Also, pomegranate consumption can reduce body weight, BMI, WC, and BFP in obese adults. Long‐term trials with different doses of pomegranate are needed.
Generation of Complex Polyhedral Building Models by Integrating Stereo-Aerial Imagery and Lidar Data

The integration of lidar data and aerial imagery is a promising approach for accurate building model generation. In this research, lidar data and stereo-aerial imagery are incorporated in the generation of complex polyhedral building models whose rooftops are bounded by straight lines. The process starts by utilizing lidar data for deriving building hypotheses and the initial boundaries of the planar patches constituting the buildings' rooftops. The boundaries of these patches are then refined through the incorporation of stereo-aerial imagery while utilizing 3D geometric and spectral constraints. Precise building boundaries are derived through resolving feature matching problems and fully utilizing spectral information. Finally, an efficient manual mono-plotting procedure is introduced to remove incorrect and add missing boundaries. The performance of the developed procedures is evaluated through experimental results from real data where the correctness, completeness, and accuracy of the derived building models are evaluated through comparison with a manually generated DBM.