Miracle-dz/UniFAR-FTUs huggingface dataset:
Comprehensive Analysis of m6A Modi�cation in Immune In�ltration, Metabolism and Drug Resistance in Hepatocellular Carcinoma

N6-methyladenosine (m6A) is important in regulating mRNA stability, splicing, and translation, and it also contributes to tumor development. However, there is still limited understanding of the comprehensive effects of m6A modi�cation patterns on the tumor immune microenvironment, metabolism, and drug resistance in hepatocellular carcinoma (HCC). In this study, we utilized unsupervised clustering based on the expression of 23 m6A regulators to identify m6A clusters. We identi�ed differential m6A modi�cation patterns and characterized m6A-gene-cluster A, which exhibited poorer survival rates, a higher abundance of Treg cells, and increased expression of TGF β in the tumor microenvironment (TME). Additionally, m6A-gene-cluster A demonstrated higher levels of glycolysis activity, cholesterol metabolism, and fatty acid biosynthesis. We also found that the m6A score was associated with prognosis and drug resistance. Patients with a low m6A score experienced worse prognoses, which were linked to an abundance of Treg cells, upregulation of TGF β , and increased metabolic activity. HCC patients with a higher m6A score showed improved prognosis following sorafenib treatment and immunotherapy. In conclusion, we reveals the association between m6A modi�cation patterns and the tumor immune microenvironment, metabolism, and drug resistance in HCC. Furthermore, the m6A score holds potential as a predictive factor for the e�cacy of targeted therapy and immunotherapy in HCC.
Cockroach Milli-Robot With Improved Load Capacity

In the field of milli-robots, several methods of constructing robots by laminating materials and then folding have been developed. Among these methods, smart composite microstructures (SCM) is widely used for making lightweight small mobile robots. However, in the case of a robot manufactured by the SCM method, due to flexible and easily deformable links and joints, it is often difficult to obtain proper kinematic movement due to deformation of the structure when a heavy load is applied. In this paper, studies on the mechanism design and manufacturing were carried out to increase the load capacity of robots manufactured by SCM. First, we modified the kinematics of the robot to reduce off-axis loading on flexure joints by using a planar 6 bar leg mechanism, which was fabricated using a new multilayer SCM process. Second, the fabrication process is improved to reduce peeling of laminate structures by introducing integrated rivets at joints. Finally, alternative materials, such as balsa, are used. To verify the design and fabrication improvements, we compared the payloads after applying the proposed methods to an existing cockroach robot design. Compared to the previous design, speed with a 50-g payload increased from 7 to 30 cm per second.
Verschiedene Gründüngerpflanzen – Anbaueignung undUnkrautunterdrückung im Direktsaatsystem vor Winterweizen

In a small-plot field trial 33 green manure plants (GM) were examined for their ability to suppress weeds in a no-tillage system. A roll-chopper was used to suppress the GMs before seeding winter wheat. The success of this organic method to control GMs was compared to the standard method using a non selective herbicide. Species of the group brassicaceae, monocotyles and plant mixtures covered the soil faster, produced more biomass and suppressed weeds more efficiently than species of the group legumes and dicotyles. In spring, weed infestation in all roll-chopper treatments always exceeded economic threshold values whereas in the herbicide treatment weed infestations remained below these values. Additionally, wheat yield and density was reduced in the roll-chopper treatment compared to the herbicide treatment. Application of the roll-chopper together with a suitable GM for Swiss growing conditions will have to be improved before its introduction for no tillage agriculture in organic farming.
Hydrothermal Liquefaction of Lignocellulosic Biomass to Liquid Biofuels: A Review

The realization that fossil fuels are fast depleting has accelerated the search for an alternative energy source that is renewable, economical, and environmentally friendly. The situation has been exacerbated by global warming which has brought it home to all that there is a need to conserve energy and reduce collectively man’s global carbon footprint. The instability in the regions from which the fossil fuels are sourced is another caused for concern, also higher oil price threatens the independence and security of nation states all this are unacceptable, hence there is need to search for more stable alternative sources of energy which is CO2 neutral fuels from biomass, Biomass is a renewable; CO2- neutral source of energy. Lignocellulosic biomass a biomass from grass, wood, and other non-food components is being considered by biofuel industries as a good agent for biofuel production, several methods are being used for this conversion, Hydrothermal liquefaction found to be the most suitable for this process, this is because the products from the hydrothermal liquefaction are insoluble in water, more deoxygenated, and have higher energy densities which are beneficial to their uses as the liquid fuels. The bio-crude produced by the hydrothermal liquefaction has also shown high stability in accelerated aging tests. This article reviews on the liquid biofuel produce from the hydrothermal liquefaction process of lignocellulosic material, including the material sources and composition and the mechanism of the process.
Efficacy of condensed tannins against larval Hymenolepis diminuta ( Cestoda ) in 1 vitro and in the intermediate host Tenebrio molitor ( Coleoptera ) in vivo 2

Dhakal, S. , Meyling, N. V. , Williams, A. R. , Mueller-Harvey, I. , Fryganas, C. , Kapel, C. M.O. and Fredensborg, B. L. (2015) Efficacy of condensed tannins against larval Hymenolepis diminuta (Cestoda) in vitro and in the intermediate host Tenebrio molitor (Coleoptera) in vivo. Veterinary Parasitology, 207 (1-2). pp. 49-55. ISSN 03044017 doi: 10.1016/j.vetpar. 2014.11. 006 Available at http://centaur.reading. ac.uk/38468/
TRPV1: A Target for Next Generation Analgesics

Transient Receptor Potential Vanilloid 1 (TRPV1) is a Ca2+ permeant non-selective cation channel expressed in a subpopulation of primary afferent neurons. TRPV1 is activated by physical and chemical stimuli. It is critical for the detection of nociceptive and thermal inflammatory pain as revealed by the deletion of the TRPV1 gene. TRPV1 is distributed in the peripheral and central terminals of the sensory neurons and plays a role in initiating action potentials at the nerve terminals and modulating neurotransmitter release at the first sensory synapse, respectively. Distribution of TRPV1 in the nerve terminals innervating blood vessels and in parts of the CNS that are not subjected to temperature range that is required to activate TRPV1 suggests a role beyond a noxious thermal sensor. Presently, TRPV1 is being considered as a target for analgesics through evaluation of different antagonists. Here, we will discuss the distribution and the functions of TRPV1, potential use of its agonists and antagonists as analgesics and highlight the functions that are not related to nociceptive transmission that might lead to adverse effects.
Projected Changes in NOx Emissions from Lightning as a Result of 2000–2050 Climate Change

Abstract Lightning is one of the most important natural sources of atmospheric NOx. The authors investigate the 2000-2050 changes in NOx emissions from lightning using the global three-dimensional Goddard Earth Observing System chemical transport model (GEOS-Chem) driven by meteorological fields from the Goddard Institute for Space Studies (GISS) general circulation model (GCM) 3. Projected changes in climate over 2000-2050 are based on the Intergovernmental Panel on Climate Change (IPCC) A1B scenario. The global NOx emission from lightning is simulated to be 4.8 Tg N in present day and to increase by about 16.7% over 2000-2050 as a result of the future climate change. The largest present-day emissions and climate-induced changes are found in the upper troposphere in the tropics. Regionally in eastern China (20-55°N, 98-125°E), NOx emissions from lighting is simulated to be 0.3 Tg N (6.3% of the global total emission) in present day and to increase by 26.7% over 2000-2050. The simulated changes in NOx from lightening correspond well with the projected future changes in convective precipitation.
Numerical Analysis on Aerodynamic Performance of Counter-rotating Wind Turbine through Rear Rotor Configuration

Numerical analysis was conducted on the aerodynamic performance and the flow characteristics around the counter-rotating wind turbine or CRWT blade through rear rotor configuration using various rotor diameter ratios and distance ratios to the turbine blade through a CFD (Computational Fluid Dynamics) simulation. CFD simulation showed the normalized power coefficients of the front rotor, rear rotor, and combined rotor (CRWT) to the single rotor with a strong influence of the rear rotor configuration with the addition of tip speed ratio (TSR). A larger average normalized power coefficient takes place at D1/D2=1.0 with L/D1=0.75 by 1.221. It is about 22.1% increased to the SRWT for the given TSR range. Axial velocity contours and resultant velocity vectors around the CRWT blade with a diameter ratio of D1/D2 > 1.0 and a closer rotor distance provide a stronger bound vortex and strong separation around the rear hub blade with a tendency to increase from the hub to the tip blade at low TSR. The higher the TSR, the movement of tip vortex moves closer to the rear tip blade which has the effect of increasing the leakage flow in the area of D1/D2 < 1.0.
VIRTUAL TRADE DIALOGUES WITH BUSINESS – TRADE 4 CLIMATE 26 OCTOBER 2021, 14.00-17.00 Background Note CARBON CONTENT OF INTERNATIONAL TRADE1

1.1. How does international trade affect climate change? To answer this question, conventional estimates often calculate the amount of greenhouse gas (GHG) emissions embodied in international trade. A number of studies find that about 20-30% of total carbon emissions (which account for most GHG emissions) are associated with international trade (e.g. Peters et al., 2011, Meng et al., 2018, Zhang et al., 2020). Nonetheless, these estimates might be subject to measurement errors and uncertainties due to the different estimation approaches and assumptions
Value-at-risk given a linguistic perspective -- Some preliminary observations

This article provides an overview of three diverse fuzzy logic methodologies that can be employed to compute the value-at-risk of a portfolio, given a linguistic perspective. The methodologies are: fuzzy histograms, credibility measures, and a fuzzy Chebyshev inequality. Some preliminary observations about how they can be implemented are also provided. The article concludes with a comment on the material covered and suggestions for further studies.
Assessment of the performance correlation, agronomic characteristics, and drought tolerance indices in corn hybrids under late season moisture stress conditions

Abstract. This study aimed to investigate the performance correlation, agronomic characteristics and drought tolerance indices in sorghum hybrids under late season moisture stress conditions in a randomized complete block design with four replications. In both normal irrigation and drought stress conditions, the number of kernels per corn showed the highest correlation with seed yield by (r= 0.977) and (r= 0.952), respectively. The results of the describing data indicate that there was a positive and significant correlation between GMP, MP, STI and TOL indices with YP and YS at 1% probability level, Whereas, SSI index had negative and non significance correlation to Yp and Ys.
Estudios de Fonética Experimental

This paper describes the main phonetic features of an Italian L1 74 y. o. speaker (ESO01) after he endured total laryngectomy in 2015 with the complete removal of vocal folds due to five tumour masses. We offer an acoustic analysis of the spontaneous speech of this target speaker, in order to lay ground to the development of spontaneous speech enhancement and reconstruction algorithms for non-invasive aids. A semi-automatic analysis extracts formants’ values (F0, F1, F2, F3) on the midpoint and on 7 time-points, together with other acoustic cues. Our results show that our target speaker presents a low and rough voice, but his vowels are clearly differentiated. Furthermore, we find vocoid and air release to be extremely consistent in his acoustic characteristics during oesophageal phonation.
Persistent organic pollutants in lacustrine environments

Water samples taken from nine English freshwater lakes from a mix of urban, rural, and remote locations on 13 occasions between April 2008 and February 2012 were analysed for selected non-dioxin like-PCBs, tri- through hexa-PBDEs, and the three main HBCD diastereomers (\(\alpha\)-, \(\beta\)-, and \(\gamma\)-HBCD). Concentrations of PCBs and HBCDs declined over the sampling period with half-lives of 3.8 and 5.1 years, respectively. In addition, concentrations of PCBs, HBCDs, tri- through deca-BDEs, and 32 selected NBFRs were measured in radiometrically-dated sediment core slices taken in summer 2011/2 from seven of the same English lakes. Temporal trends in contamination with “legacy” POPs generally accord with historical trends in UK manufacture and use, with PCB contamination at all lakes increasing from ~1950, peaking generally between the late-1960s and mid-1980s, before declining steadily thereafter. In contrast, at most sites, BDE-209 displayed generally smooth increases following its initial emergence, and showed no obvious levelling off trend. Contamination with some NBFRs displayed significantly increasing trends. Spatial variation in POPs contamination of the lakes studied was evident; with regression analysis suggesting concentrations are higher in lakes with surface areas that are small relative to their catchment area, and that are closer to areas of high population density. The estimated PCB burden in the British environment is 521 tons, with TBPH (281 tons) and BDE-209 (147 tons) following not far behind. Estimated UK burdens of the remaining target compounds were significantly lower.
Machine Learning Models to Assess the Impact of Weather Conditions on Cardiac Arrest

: In general, some studies suggest that the risk of cardiac arrests is higher in winter than in summer. It has also been clinically proven that winters increase the chances of cardiac arrests. We are also seeing it empirically. The number of outpatient visits to the hospital with problems such as heart pain and a feeling of heaviness in the heart increases by 30 percent in winter. Also, the number of hospitalizations for serious cardiac arrests has increased by 10 percent, according to statistics. What is the relationship between winter and cardiac arrests, and whether it is possible to prevent cardiac arrests in winter; various types of research are being carried out. Especially in the months of November, December and January, more patients come to the hospital with cardiac arrest symptoms and cardiac arrests than usual. In this paper, Machine Learning Model has proposed to assess the Impact of Weather Conditions on Cardiac Arrest. There are three main causes of cardiac arrest in cold weather. Cholesterol blocks deposited in heart blood vessels will break down and spread. The fat that spreads like that causes blood clots in the blood vessels. This causes a cardiac arrest. As the cold increases in winter, blood vessels become more constricted. Hence, the chances of fat loss will also increase. That is why the chances of cardiac arrests increase in winter.
Prospects for distance education training among vegetable producers in Trinidad and Tobago

This study enquired of the option of Distance Education as a mode for delivering agricultural information and training within the Extension services of Trinidad and Tobago. The researchers selected each member of the total population of frontline Extension workers in Trinidad and Tobago for a structured interview. Similarly the researchers selected a population of vegetable producers from the major vegetable growing areas in the country. There were respective response rates of 83% and 80%. There was a significant association between years of Extension agent service and interest in using the facility. Agents revealed interest in a range of topics appropriate for Vegetable production. Both agents and their clients felt that the tool will be useful in their training. Agents identified several support factors which would hinder implementation and which could be alleviated by Extension leadership and management. The first four factors were Funding, Support Service, Availability of resource material and administrative policy. Current sources of information, ownership of information sources, access to information communication technologies and willingness to become involved were attributes which both clients and their agents possess. These are essential first elements for the successful delivery of Distance Education programmes. The assessment provided adequate evidence to suggest that Distant Education can be used among vegetable producers in Trinidad and Tobago. Extension agents can be trained via the method and they can train their clients. In so doing the sources and type of information available to the Agricultural community can be suitably enhanced. Introduction This study enquires of the option of Distance Education as a departure from traditional modes of delivering agricultural information and training within the Extension services of Trinidad and Tobago. Distance education has not been widely used to train Extension agents and farmers in Trinidad and Tobago. Yet studies have shown that countries which regularly use Distance Education in agricultural training programmes experience consequent increases in the quantity and quality of farm product. Since 1992, the agricultural sector’s contribution to GDP has steadily declined from 2.5% to a 0.7% contribution in 2005 (Central Statistical Office (CSO), 2005) There are national Food Security objectives which attempt to maintain growth within the agricultural sector more so, AIAEE 22 Annual Conference Proceedings Clearwater Beach, Florida 195 vegetable production for the domestic market. There is a fledgling yet diverse farming and food crop base in the country. Over the past fifteen years food imports continue to exceed exports as farmers are unable to meet the needs of consumers. In delivering Extension services to meet the need for improved production, distance education may be an effective mode of delivery in order to increase competence, knowledge and awareness.
Non-mouillant et température : application aux revêtements culinaires

Si l’eau d’une riviere coule sous l’influence d’une petite pente, une goutte de pluie millimetrique s’accroche generalement a son substrat. Cette these considere les problemes engendres par cette adhesion liquide-solide a l’aune de l’application culinaire. Nous nous interessons aux surfaces superhydrophobes dont la chimie et la rugosite rendent ces solides non-adherents. Par ailleurs, le comportement de ces materiaux en temperature rend compte de differents domaines d’adhesion. Ces surfaces voient leur adhesion augmenter avec la temperature lorsque la vapeur se recondense au sein des textures du solide. Mais, a mesure que la temperature s’eleve, des bulles de vapeur se forment et reduisent l’adhesion, jusqu’a l’annuler lorsque le liquide levite sur un coussin continu de vapeur. Nous decrivons cet etat, dit de calefaction, et notamment l’origine de la temperature critique pour laquelle ce phenomene apparait. La superhydrophobie permet de reduire considerablement cette temperature, dite de Leidenfrost, et de rendre accessible la calefaction pour des temperatures typiques de cuisson. Enfin, nous comparons ces resultats aux strategies de non-adhesion culinaire : a savoir les revetements hydrophobes et l’utilisation d’huile. Des surfaces mixtes piegeant une fine couche d’huile dans des textures hydrophobes sont ainsi discutees.
In Silico Prediction of Peroxisomal Proteins in Mouse

Peroxisomes are small vesicle-like subcellular respiratory organelles present in virtually all eukaryoticcells. Peroxisomes are involved in lipid metabolism, such as -oxidation of fatty acids, synthesis ofsterols and bile acids and also in glyoxylate metabolism and gluconeogenesis [3]. The importanceof peroxisomes is underscored by the existence in human of a group of serious metabolic disorderscaused either by impairment of peroxisome biogenesis or by defects of individual peroxisomal enzymes.Despite the fact that peroxisomes were rst discovered in the 1960s, the functions performed by theseorganelles are still not fully understood. Identi cation of all peroxisome components will aid in ourunderstanding of peroxisome biology and discovery of molecular targets to treat disorders associatedwith this organelle.
Development and evaluation of methods for recovery Of Noroviruses FROM food, water and air

Foodborne outbreaks caused by noroviruses (NoVs) and hepatitis A virus (HAV) are often linked to consumption of contaminated shellfish. The objective of this study was to identify an appropriate virus recovery method for real-time reverse transcriptase (RT)-PCR detection and subsequently to evaluate this method on shellfish bioaccumulated with virus in a collaborative study. Five methods were compared for recovery of NoV GII.7 and feline calicivirus from spiked digestive tissue of oysters andmussels. A method based on proteinase K digestion followed by NucliSENS miniMAG extraction was found to be the most efficient with a 50% limit of detection (LOD50) of 62 and 12 RT-PCR U/1.5 g digestive tissue for NoV GII.7 in oysters and mussels, respectively. Evaluation of the method in four laboratories found the percentage of sensitivity, based on low/high levels of virus bioaccumulated in oysters, to be 33/80 for NoV GI.3b, 13/92 for NoV GII.4 and 50/42 for HAV. A specificity of 100% was found for all three viruses in non-bioaccumulated oysters. As process control Mengovirus (vMC0) showed an average recovery of 1.8% from oysters and 1.2% frommussels. The study demonstrates that this recovery method can be useful for harmonized data generation and routine viral analyses of shellfish. © 2010 Elsevier B.V. All rights reserved.
Location determinants of new foreign-owned manufacturing plants

Manufacturing employment in the United States has tended to fall since 1979. Geographically, the Northeast and Mideast regions have incurred the brunt of this decline and, except in the Southwest region, urban countries have tended to fare worse than rural countries. Meanwhile, foreign-owned manufacturing has been playing a larger role in the U.S. economy, especially in the Great Lakes and Southeast regions. The current research explains the pattern-among regions as well as between rural and urban countries-of new foreign plant location. Proxies measuring economic size, labor force quality, agglomeration and urbanization economies, and transportation infrastructure are found to affect the location of new foreign-owned plants positively, while proxies for unit labor costs and taxes are found to deter the location of new plants. The key advantages of the Great Lakes region stem from relatively low unit labor costs and high manufacturing density, while high manufacturing density and low taxes are the key advantages of the Southeast region. Comparing urban with rural countries, nearly all the explanatory variables possess average values for urban countries that are more favorable to foreign direct investment. For example, the labor force is relatively more productive and skilled in urban than in rural countries.