Miracle-dz/UniFAR-FTUs huggingface dataset:
Spin-wave relaxation and phenomenological damping in ferromagnetic resonance

Relaxation rates for the uniform precession mode in ferromagnetic resonance, with general elliptical polarization, have been calculated for several microscopic scattering processes using the spin-wave formalism. These results are compared with the widely used phenomenological formulations for ferromagnetic resonance. The results demonstrate in relatively general terms the specific features of the Landau-Lifshitz and Gilbert phenomenological formulations on the one hand, and of what may be called "intrinsic" confluence processes in the microscopic formulation. These formulations are consistent with the assumption of an intrinsic damping parameter describing the motion of the magnetization vector under sufficiently general conditions. The two-magnon process and the Bloch-Bloembergen phenomenological description of damping in ferromagnetic resonance are not consistent with such an assumption.
Mechanical stretching of proteins—a theoretical survey of the Protein Data Bank

The mechanical stretching of single proteins has been studied experimentally for about 50 proteins, yielding a variety of force patterns and peak forces. Here we perform a theoretical survey of proteins of known native structure and map out the landscape of possible dynamical behaviours under stretching at constant speed. We consider 7510 proteins comprising not more than 150 amino acids and 239 longer proteins. The model used is constructed based on the native geometry. It is solved by methods of molecular dynamics and validated by comparing the theoretical predictions to experimental results. We characterize the distribution of peak forces and investigate correlations with the system size and with the structure classification as characterized by the CATH scheme. Despite the presence of such correlations, proteins with the same CATH index may belong to different classes of dynamical behaviour. We identify proteins with the biggest forces and show that they belong to few topology classes. We determine which protein segments act as mechanical clamps and show that, in most cases, they correspond to long stretches of parallel β-strands, but other mechanisms are also possible.
Medical student’s artificial intelligence education and research experiences

Received: October 24, 2022 • Revised: November 7, 2022 • Accepted: November 7, 2022 Corresponding Author: Chaeyeong Im (https://orcid.org/0000-0001-9045-8581) College of Medicine, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju 61469, Korea Tel: +82.62. 220.4006 Fax: +82.62. 232.9708 email: idisdanielcy@gmail.com Korean J Med Educ 2022 Dec; 34(4): 341-344 https://doi.org/10.3946/kjme.2022. 243 eISSN: 2005-7288 C The Korean Society of Medical Education. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The impact of dementia, frailty and care home characteristics on SARS-CoV-2 incidence in a national cohort of Welsh care home residents during a period of high community prevalence

Abstract Background dementia may increase care home residents’ risk of COVID-19, but there is a lack of evidence on this effect and on interactions with individual and care home-level factors. Methods we created a national cross-sectional retrospective cohort of care home residents in Wales for 1 September to 31 December 2020. Risk factors were analysed using multi-level logistic regression to model the likelihood of SARS-CoV-2 infection and mortality. Results the cohort included 9,571 individuals in 673 homes. Dementia was diagnosed in 5,647 individuals (59%); 1,488 (15.5%) individuals tested positive for SARS-CoV-2. We estimated the effects of age, dementia, frailty, care home size, proportion of residents with dementia, nursing and dementia services, communal space and region. The final model included the proportion of residents with dementia (OR for positive test 4.54 (95% CIs 1.55–13.27) where 75% of residents had dementia compared to no residents with dementia) and frailty (OR 1.29 (95% CIs 1.05–1.59) for severe frailty compared with no frailty). Analysis suggested 76% of the variation was due to setting rather than individual factors. Additional analysis suggested severe frailty and proportion of residents with dementia was associated with all-cause mortality, as was dementia diagnosis. Mortality analyses were challenging to interpret. Discussion whilst individual frailty increased the risk of COVID-19 infection, dementia was a risk factor at care home but not individual level. These findings suggest whole-setting interventions, particularly in homes with high proportions of residents with dementia and including those with low/no individual risk factors may reduce the impact of COVID-19.
Structure and scaling properties of the geodesic acoustic mode

Characteristics and scaling properties of the geodesic acoustic mode (GAM), a coherent, radially-sheared high frequency (∼15 kHz) zonal flow oscillation, are studied systematically using time-delay-estimation techniques applied to localized, multi-point density fluctuation measurements obtained by beam emission spectroscopy on DIII-D. The GAM amplitude is shown to increase strongly with increasing safety factor, q95, and to likewise become undetectably small for q95 < 4.2, qualitatively consistent with theoretical predictions based on collisional damping as well as simulations. The radial structure of the GAM exhibits peak amplitude in the radial range 0.88 < r/a < 0.95 with a rapid amplitude reduction inside and outside this region. The measured frequency is close to the predicted frequency, though some deviation to higher frequency is observed at lower q. The GAM amplitude is also shown to increase with plasma elongation, κ, while its frequency decreases.
A theoretical analysis of the non-uniform mutation operator for the modified genetic algorithm

This paper presents a theoretical investigation of Michalewicz's non-uniform mutation operator proposed for his modified variant of genetic algorithms modGA to tackle numerical parameter optimization problems. As is shown by mathematical analysis, the non-uniform mutation operator prefers parameter values in the center of the corresponding feasible region. This leads to problems if the optimum is situated near the boundaries of the feasible region. In order to avoid this undesirable tendency, an adaptive non-uniform mutation operator is proposed, the development of which rests on the mathematical analysis. Experimental results for a standard numerical parameter optimization problem are given that illustrate the superiority of this novel mutation operator.
Response regulator PorX coordinates oligonucleotide signalling and gene expression to control the secretion of virulence factors

Abstract The PglZ family of proteins belongs to the alkaline phosphatase superfamily, which consists of metallohydrolases with limited sequence identity but similar metal-coordination architectures in otherwise divergent active sites. Proteins with a well-defined PglZ domain are ubiquitous among prokaryotes as essential components of BREX phage defence systems and two-component systems (TCSs). Whereas other members of the alkaline phosphatase superfamily are well characterized, the activity, structure and biological function of PglZ family proteins remain unclear. We therefore investigated the structure and function of PorX, an orphan response regulator of the Porphyromonas gingivalis TCS containing a putative PglZ effector domain. The crystal structure of PorX revealed a canonical receiver domain, a helical bundle, and an unprecedented PglZ domain, similar to the general organization of the phylogenetically related BREX-PglZ proteins. The PglZ domain of PorX features an active site cleft suitable for large substrates. An extensive search for substrates revealed that PorX is a phosphodiesterase that acts on cyclic and linear oligonucleotides, including signalling molecules such as cyclic oligoadenylates. These results, combined with mutagenesis, biophysical and enzymatic analysis, suggest that PorX coordinates oligonucleotide signalling pathways and indirectly regulates gene expression to control the secretion of virulence factors.
Interventions to facilitate interprofessional collaboration in the operating theatre: A scoping review

Background: Ineffective collaboration can increase adverse events in the operating theatre. When professionals work collaboratively, they are more likely to improve patient safety and outcomes. Aim: To identify interprofessional collaboration interventions involving operating theatre teams and describe their effect on facilitating communication, teamwork, and safety. Methods: A scoping review of four databases. Results were analysed by identifying interventions and mapping their related outcomes. Results: Twenty studies evaluated single or multi-faceted interventions. Despite low-quality study designs (no randomised controlled trials), four interventions (eg: briefings, checklists, team training, debriefing) improved communication and teamwork, and enhanced safety outcomes. Only one study, using team training, reported that organisational level interventions (eg: Standard Operating Procedures, Lean quality improvement management system) improved teamwork and safety outcomes. Conclusion: Several studies reported interventions enhanced interprofessional collaboration within operating theatre teams. Although findings were in favour of improved communication and teamwork, more rigorous research is required.
Effects of APOE ε2 allele on basal forebrain functional connectivity in mild cognitive impairment

Basal forebrain cholinergic system (BFCS) dysfunction is associated with cognitive decline in Alzheimer's disease (AD) and mild cognitive impairment (MCI). Apolipoprotein E (APOE) ε2 is a protective genetic factor in AD and MCI, and cholinergic sprouting depends on APOE.
RANS-Based Very Large Eddy Simulation of Thermal and Magnetic Convection at Extreme Conditions

For thermal and magnetic convection at very high Rayleigh and Hartman numbers, which are inaccessible to the conventional large eddy simulation, we propose a time-dependent Reynolds-average-Navier-Stokes (T-RANS) approach in which the large-scale deterministic motion is fully resolved by time and space solution, whereas the unresolved stochastic motion is modeled by a "subscale" model for which an one-point RANS closure is used. The resolved and modeled contributions to the turbulence moments are of the same order of magnitude and in the near-wall regions the modeled heat transport becomes dominant, emphasizing the role of the subscale model. This T-RANS approach, with an algebraic stress/flux subscale model, verified earlier in comparison with direct numerical simulation and experiments in classic Rayleigh-Benard convection, is now expanded to simulate Rayleigh-Benard (RB) convection at very high Ra numbers-at present up to O(10 16 )-and to magnetic convection in strong uniform magnetic fields. The simulations reproduce the convective cell structure and its reorganization caused by an increase in Ra number and effects of the magnetic field. The T-RANS simulations of classic RB indicate expected thinning of both the thermal and hydraulic wall boundary layer with an increase in the Ra number and an increase in the exponent of the Nu ∝ Ra" correlation in accord with recent experimental findings and Kraichnan asymptotic theory.
Evaluation of sexual functional status and consistency of scales in patients with hypogonadotropic hypogonadism before and after testosterone replacement therapy: a single-center experience

ABSTRACT Objective: This study aimed to investigate the frequency of sexual dysfunction and the effect of short-term testosterone replacement therapy on sexual functions in congenital hypogonadism patients. Furthermore, we sought to reveal the consistency of the self-report scales used for the diagnosis of sexual dysfunction and the relationship between biochemical parameters. Materials and methods: The study was conducted on 47 young male patients aged above 18 years who were diagnosed with hypogonadotropic hypogonadism. Short (IIEF-5) and long (IIEF-15) forms of the International Index of Erectile Function and Arizona Sexual Experiences Scale (ASEX) were applied before treatment under the supervision of a physician. The patients’ blood pressure, height, and weight were measured, and their luteinizing hormone (LH), FSH, and total testosterone levels were recorded. Patients who started their treatments were called for a follow-up checkup after 6 months. Their blood pressure, height, and weight were measured by reapplying the ASEX, IIEF-5, and IIEF-15. In addition, their LH, FSH, and total testosterone levels in the biochemical tests were rerecorded. Results: In this study, the sexual dysfunction status of patients diagnosed with hypogonadotropic hypogonadism before and after treatment was evaluated using the ASEX, IIEF-15, and IIEF-5 scales. A decrease in sexual dysfunction was observed in all three scales after treatment compared with that before treatment. The IIEF-5 and IIEF-15 scales were found to be uncorrelated in terms of the pretreatment values but were correlated in terms of the post-treatment values. Although a correlation was observed between ASEX and IIEF-5 before treatment, no correlation was detected between ASEX and IIEF-15. After the treatment, ASEX was found to be correlated with both IIEF-5 and IIEF-15. The results of the scales indicated the correlation in all categories, except the pretreatment results of the IIEF-15 scale. Conclusion: The results of the current study demonstrated a significant improvement in the sexual function of hypogonadism patients undergoing short-term testosterone therapy. The ASEX, IIEF-5, and IIEF-15 scales used in the diagnosis and follow-up of sexual dysfunction were useful for evaluating sexual functions in hypogonadotropic hypogonadism patients.
Diets of infants and young children in two counties of Kenya: Key drivers and barriers to improvement

Abstract Infant and young child feeding (IYCF) practices are influenced by many context‐specific factors related to local food systems as well as social and cultural practices. Understanding these local contextual perspectives is essential for designing effective programs and policies. This paper uses focused ethnographic study methods to examine challenges experienced by mothers related to IYCF in two counties in Kenya, a country with considerable heterogeneity in agriculture, food systems, and cultures. A two‐phase qualitative study was undertaken in each of Kilifi County and West Pokot County, entailing interviews and rating activities with mothers, health workers, and vendors. Interviews were audio‐recorded, transcribed, translated into English, coded, and analysed by topic. Results show low levels of dietary diversity in both counties; in West Pokot, the level of adequate meal frequency is also low. Core foods in young child diets included maize porridge and family foods such as ugali (stiff maize porridge), vegetables, beans, fish, and plantains. Food safety, acceptability, and acquisition ease were the main drivers of food choice. Mothers generally felt that all core foods fed to young children are healthy and safe, but there was more variability regarding child acceptance, acquisition ease, cost, and convenience. Common barriers to feeding nutrient‐dense foods to children included child illness, economic constraints, and limited knowledge of modification strategies, skills, or tools to make the foods suitable for young children. Potential actions to address these barriers include sharing information on child‐appropriate recipes; raising awareness on local, affordable nutrient‐dense foods; and improving WASH practices to reduce illness frequency.
Synthesis of heat exchanger networks with nonisothermal phase changes

Most literature on the synthesis of heat exchanger networks via mathematical programming methods has dealt with phase changes by assuming nearly isothermal conditions. Many multicomponent phase changes of practical interest (e.g., those in sub-ambient processes) occur over ranges of temperatures and exhibit nonlinear temperature-enthalpy relations (T-H curve). In such cases, isothermal approximations may lead to inferior or unacceptable networks. In this article, we propose a mixed-integer nonlinear programming formulation and a solution algorithm to incorporate nonisothermal phase changes in heat exchanger network synthesis. We approximate the nonlinear T-H curves via empirical cubic correlations, and propose a procedure to ensure minimum temperature approach at all points in the exchangers. Our approach successfully solves two industry examples and shows promise for significant cost reductions when compared with existing processes.
Thymosin β4 and actin: binding modes, biological functions and clinical applications.

Thymosin β4 (Tβ4) is the β-thymosin (Tβs) with the highest expression level in human cells; it makes up roughly 70-80% of all Tβs in the human body. Combining the mechanism and activity studies of Tβ4 in recent years, we provide an overview of the subtle molecular mechanism, pharmacological action, and clinical applications of Tβ4. As a G-actin isolator, Tβ4 inhibits the polymerization of G-actin by binding to the matching site of G-actin in a 1:1 ratio through conformational and spatial effects. Tβ4 can control the threshold concentration of G-actin in the cytoplasm, influence the balance of depolymerization and polymerization of F-actin (also called Tread Milling of F-actin), and subsequently affect cell's various physiological activities, especially motility, development and differentiation. Based on this, Tβ4 is known to have a wide range of effects, including regulation of inflammation and tumor metastasis, promotion of angiogenesis, wound healing, regeneration of hair follicles, promotion of the development of the nervous system, and improving bone formation and tooth growth. Tβ4 therefore has extensive medicinal applications in many fields, and serves to preserve the kidney, liver, heart, brain, intestine, and other organs, as well as hair loss, skin trauma, cornea repairing, and other conditions. In this review, we focus on the mechanism of action and clinical application of Tβ4 for its main biological functions.
Modeling of spaced‐receiver scintillation measurements

Spaced-receiver scintillation measurements are modeled applying scintillation theory together with model spectral representations of nonfrozen turbulent media. The effects of velocity distribution of scatterers, diffusion of irregularities and velocity gradient across the scattering layer on parameters derived from spaced-receiver scintillation experiments are studied. Both correlation and dispersion analyses are considered. The results from modeling are compared with observational data from the equatorial region. It will be demonstrated that self-consistent models can be constructed in interpreting the data and information about the drift velocity field in the ionosphere can be obtained from spaced-receiver experiments.
Magnetic resonance-guided focused ultrasound for the treatment of tremor

ABSTRACT Introduction Magnetic resonance-guided focused ultrasound (MRgFUS) is an emerging treatment for tremor and other movement disorders. An incisionless therapy, it is becoming increasingly common worldwide. However, given MRgFUS’ relative novelty, there remain limited data on its benefits and adverse effects. Areas covered We review the current state of evidence of MRgFUS for tremor, highlight its challenges, and discuss future perspectives. Expert opinion Essential tremor (ET) has been the major indication for MRgFUS since a milestone randomized controlled trial (RCT) in 2016, with substantial evidence attesting to the efficacy and acceptable safety profile of this treatment. Patients with other tremor etiologies are also being treated with MRgFUS, with studies – including an RCT – suggesting parkinsonian tremor in particular responds well to this intervention. Additionally, targets other than the ventral intermediate nucleus, such as the subthalamic nucleus and internal segment of the globus pallidus, have been reported to improve parkinsonian symptoms beyond tremor, including rigidity and bradykinesia. Although MRgFUS is encumbered by certain unique technical challenges, it nevertheless offers significant advantages compared to alternative neurosurgical interventions for tremor. The fast-growing interest in this treatment modality will likely lead to further scientific and technological advancements that could optimize and expand its therapeutic potential.
Human and Animal Fascioliasis: Origins and Worldwide Evolving Scenario

Fascioliasis is a plant- and waterborne zoonotic parasitic disease caused by two trematode species: (i) Fasciola hepatica in Europe, Asia, Africa, the Americas, and Oceania and (ii) F. gigantica, which is restricted to Africa and Asia. Fasciolid liver flukes infect mainly herbivores as ruminants, equids, and camelids but also omnivore mammals as humans and swine and are transmitted by freshwater Lymnaeidae snail vectors. SUMMARY Fascioliasis is a plant- and waterborne zoonotic parasitic disease caused by two trematode species: (i) Fasciola hepatica in Europe, Asia, Africa, the Americas, and Oceania and (ii) F. gigantica, which is restricted to Africa and Asia. Fasciolid liver flukes infect mainly herbivores as ruminants, equids, and camelids but also omnivore mammals as humans and swine and are transmitted by freshwater Lymnaeidae snail vectors. Two phases may be distinguished in fasciolid evolution. The long predomestication period includes the F. gigantica origin in east-southern Africa around the mid-Miocene, the F. hepatica origin in the Near-Middle East of Asia around the latest Miocene to Early Pliocene, and their subsequent local spread. The short postdomestication period includes the worldwide spread by human-guided movements of animals in the last 12,000 years and the more recent transoceanic anthropogenic introductions of F. hepatica into the Americas and Oceania and of F. gigantica into several large islands of the Pacific with ships transporting livestock in the last 500 years. The routes and chronology of the spreading waves followed by both fasciolids into the five continents are redefined on the basis of recently generated knowledge of human-guided movements of domesticated hosts. No local, zonal, or regional situation showing disagreement with historical records was found, although in a few world zones the available knowledge is still insufficient. The anthropogenically accelerated evolution of fasciolids allows us to call them “peridomestic endoparasites. ” The multidisciplinary implications for crucial aspects of the disease should therefore lead the present baseline update to be taken into account in future research studies.