Miracle-dz/UniFAR-FTUs huggingface dataset:
Serially mediated effects of psychological inflexibility on quality of life of refugees in Uganda during coronavirus pandemic

The unexpected outbreak and rapid spread of COVID-19 necessitated radical and stringent control measures, consequently changing how people live globally. To vulnerable populations like refugees, who were already living a disrupted life, the outbreak of COVID-19 and accompanying control measures complicated their living conditions and drastically affected their mental health and, consequently, their quality of life. The current study aimed to test whether psychological inflexibility was a factor in lowering the quality of life of refugees in Uganda during the COVID-19 pandemic. The study further examines whether the effects of psychological inflexibility on quality of life were serially mediated by avoidance coping, perceived threat, adherence to COVID-19 control measures, and general mental health states. The study was conducted among refugees living in Kampala city suburbs and Bidibidi refugee settlement in Uganda. Data was collected using a survey questionnaire during the partial reopening of the economy in mid-2020, after the first lockdown. The analysis assesses a serial mediation model of the effects of psychological inflexibility on the quality of life of refugees through avoidance coping, perceived threat, adherence to COVID-19 control measures, and mental health using PROCESS Macro. The study involved 353 participants. Our analyses revealed that psychological inflexibility was negatively associated with the perceived threat, adherence, and quality of life. Psychological inflexibility was positively associated with avoidance coping and poor mental health. The data supported all hypothesized mediation paths. These findings support literature suggesting that psychological inflexibility is a maladaptive attribute that thwarts positive coping and behavior adjustment in times of crisis. Consequently, psychological inflexibility can worsen mental health problems and quality of life, especially in populations such as refugees in low-income countries who live in precarious conditions. Incorporating interventions that reduce psychological inflexibility in crisis management efforts can help refugees maintain good psychological functioning and quality of life.
Considering Subjects and Scenarios in Large-Scale User-Centered Evaluation of a Multilingual Multimodal Medical Search System

Khresmoi aims to provide a multilingual and multimodal search and access system for biomedical information and documents, which targets three classes of user. Two of these are groups with general medical interests: the gen- eral public and general medical practitioners. The other is an example clinician group with a specific expertise: radiologists. Khresmoi targets diverse users, with: varying native language, language skills, medical knowledge, information needs or querying behaviour. The system seeks to provide these groups with in- novative and effective services for searching through the large amount of avail- able medical information. It gathers several innovative technologies linked to medical information (e.g. information extraction and retrieval, machine transla- tion) to provide a comprehensive tool adapted to all users. In parallel to the de- velopment of the search system, a global evaluation strategy is being designed to enable an assessment of the efficiency and effectiveness of the developed technologies and of the quality of the support provided to the target users. The- se evaluation plans consist of both empirical and user-centred evaluations. We focus here on user-centred evaluations. Creation of holistic user-centred evalua- tion approaches allows to evaluate the search application in a comprehensive way while being mindful of the diversity of users. First steps in this strategy re- late to the experimental subjects and evaluation scenarios. Firstly, demographic features of each class of user have to be defined in order to get representative groups. Gaining subjects of this nature can be problematic, especially when medical professionals are required, and it raises issues such as the payment of subjects, or the geographic distance between subjects and investigators. Moreo- ver, the Khresmoi system is intended for use by individuals with different na- tive languages and different skills in the English language. Again, this raises is- sues such as gaining a good spread of subjects with different language skills, as well as the assessment of subjects' language skills. To determine the demo- graphic spread of subjects, standard questionnaires should be completed by sub- jects to determine their age, gender, medical condition, prior use of medical search engines, computer skill, etc. Secondly, a robust methodology for scenar- io creation has to be developed. User studies conducted within the project gave
Controls on snowmelt water mean transit times in northern boreal catchments

Catchment‐scale transit times for water are increasingly being recognized as an important control on geochemical processes. In this study, snowmelt water mean transit times (MTTs) were estimated for the 15 Krycklan research catchments in northern boreal Sweden. The snowmelt water MTTs were assumed to be representative of the catchment‐scale hydrologic response during the spring thaw period and, as such, may be considered to be a component of the catchment's overall MTT. These snowmelt water MTTs were empirically related to catchment characteristics and landscape structure represented by using different indices of soil cover, topography and catchment similarity. Mire wetlands were shown to be significantly correlated to snowmelt MTTs for the studied catchments. In these wetlands, shallow ice layers form that have been shown to serve as impervious boundaries to vertical infiltration during snowmelt periods and, thus, alter the flow pathways of water in the landscape. Using a simple thought experiment, we could estimate the potential effect of thawing of ice layers on snowmelt hydrologic response using the empirical relationship between landscape structure (represented using a catchment‐scale Pe number) and hydrologic response. The result of this thought experiment was that there could be a potential increase of 20–45% in catchment snowmelt water MTTs for the Krycklan experimental catchments. It is therefore possible that climatic changes present competing influences on the hydrologic response of northern boreal catchments that need to be considered. For example, MTTs may tend to decrease during some times of the year due to an acceleration in the hydrologic cycle, while they tend to increase MTTs during other times of the year due to shifts in hydrologic flow pathways. The balance between the competing influences on a catchment's MTT has consequences on climatic feedbacks as it could influence hydrological and biogeochemical cycles at the catchment scale for northern latitude boreal catchments. Copyright © 2010 John Wiley & Sons, Ltd.
Implementation of Legal Requirements for the Limitation of Combined Sewer Overflows - Situation in Austria

The Austrian standard for designing combined sewer overflow detention basins introduces the efficiency of the combined sewer overflows as an indicator for CSO pollution. Additional criteria for the ambient water quality are defined, which comprehend six kinds of impacts. In this paper the Austrian legal requirements are described and discussed by means of hydrological modelling. This is exemplified by a case study in Innsbruck (Austria), including a description for model building and model calibration. Furthermore, an example shows how - in this case – the overall system performance could be improved by implementing a cost effective rearrangement of the storage tanks already available at the inflow of the waste water treatment plant.
Sorptive protection of organic matter in soil.

Soils are a significant sink for organic carbon, which can be protected from chemical and biological change, and hence conversion into greenhouse gases, such as CO2 and CH4. In order to mitigate global climate change, and improve soil quality, the chemical mechanisms behind the long-term protection of organic matter must be understood, and strategies developed to improve this protection. Organic matter can be stabilised and protected in soil by a range of mechanisms, especially sorption. Sorption of organic matter to the surface of clay minerals via strong multiple complex bonds prevents hydrolytic enzymes approaching and decomposing the organic matter. We used clay minerals to study the sorption processes between organic matter and mineral phases, hence protection of the organic matter, that typically occur in soils. Initial results from sorption experiments show that humic acid was adsorbed more strongly to goethite than with kaolinite or montmorillonite. For all three mineral phases sorption was pH-dependent, with maximum sorption occurring at lower pH. XRD analysis in montmorillonite systems show that the sorbed humic acid decreased the‘d’ spacing of the 2:1 clay.
ATG9 resides on a unique population of small vesicles in presynaptic nerve terminals.

In neurons, autophagosome biogenesis occurs mainly in distal axons, followed by maturation during retrograde transport. Autophagosomal growth depends on the supply of membrane lipids which requires small vesicles containing ATG9, a lipid scramblase essential for macroautophagy/autophagy. Here, we show that ATG9-containing vesicles are enriched in synapses and resemble synaptic vesicles in size and density. The proteome of ATG9-containing vesicles immuno-isolated from nerve terminals showed conspicuously low levels of trafficking proteins except of the AP2-complex and some enzymes involved in endosomal phosphatidylinositol metabolism. Super resolution microscopy of nerve terminals and isolated vesicles revealed that ATG9-containing vesicles represent a distinct vesicle population with limited overlap not only with synaptic vesicles but also other membranes of the secretory pathway, uncovering a surprising heterogeneity in their membrane composition. Our results are compatible with the view that ATG9-containing vesicles function as lipid shuttles that scavenge membrane lipids from various intracellular membranes to support autophagosome biogenesis.
The microclimate of Mawson's Hut based on snow and ice core analysis

ABSTRACT We report the oxygen isotope ratio (δ18O) and structural analysis of four 2m long firn cores collected in 1997 from inside Mawson's Hut (consisting of a Main Hut and a Workshop), Commonwealth Bay, Antarctica, and 25 snow samples collected in 2001 in the vicinity of the huts. Our aim is to examine the microclimate within the huts. Structural analyses of the cores and snow samples indicate there were no significant melt and refreeze events, however there is evidence of water seepage into the huts from the roof. Oxygen isotope data from the two cores from the Main Hut indicate that the hut filled slowly after being abandoned in 1914. Two cores adjacent to the Workshop suggest comparatively rapid snow filling after it was cleared of snow in 1978. Oxygen isotope analysis of individual samples collected outside Mawson's Hut suggests snow, accumulated south of Cape Denison, is deposited by katabatic winds.
Investigation of the risk factors associated with osteoporosis in postmenopausal women

Objective: Osteoporosis is a substantial global public health issue. The objective of this study was to evaluate the risk variables associated with osteoporosis among patients seeking care at an outpatient menopausal clinic in a tertiary university hospital. Material and Methods: In this retrospective, cross-sectional study postmenopausal women who attended the outpatient menopause clinic of Başkent University Hospital between June 01, 2014, and August 31, 2015, were enrolled. Patients’ datasheets were reviewed and data including age, body mass index, parity, duration and age of menopause, history of smoking and oral contraceptive pills (OCPs) use, natural or surgical menopause, and calcium-containing food consumption were collected through a standardized questionnaire. Bone mineral density (BMD) was measured at the femur neck and lumbar spine by dual energy X-ray absorptiometry. Results: A total of 1,148 women with a mean age of 53.5±6.7 years, mean duration of menopause 7.1±6.2 years and mean age of menopause 46.3±5.1 years were identified. Of these, 235 (20.5%) were diagnosed as having osteoporosis. The average femur and lumbar T-values showed a decrease in normal weight patients compared to overweight, obese, and morbidly obese patients (F=22,337, p<0.001 and F=50,195, p<0.001, respectively). The mean femur T-values were higher in participants who used OCPs, regularly consumed a calcium-rich diet, and performed regular physical activity (p<0.05, p<0.01 and p<0.05). Positive correlations were noted between giving birth and femur T-values (r=0.065, p=0.027), between natural menopause and lumbar T-values (r=0.060, p=0.043), and between consuming a calcium-rich diet and femur T-values (r=0.087, p=0.003 and r=0.064, p=0.031, respectively). Conclusion: Using OCPs, lifelong physical activity, and a healthy diet rich in calcium are important factors for the prevention of low lumbar spine and femoral BMD and by implication, osteoporosis.
A review of Energy Efficient Routing Protocols for Mobile Ad Hoc Wireless Networks

This paper presents a survey on the art of energy efficient routing protocols for Mobile Ad-Hoc Network (MANET). Since the nodes in MANET are mobile, the routing and power management become critical issue. In this widely used field, considering both protocols and analytical frameworks for efficient energy routing. The main focus on motivation, research challenges, recent
Jurassic to Paleogene: Part 2 Paleogene geochronology and chronostratigraphy

Summary We present a revised Paleogene geochronology based upon a best fit to selected high temperature radiometric dates on a number of identified magnetic polarity chrons (within the late Cretaceous, Paleogene and Neogene) which minimizes apparent accelerations in sea-floor spreading. An assessment of first order correlations of calcareous plankton biostratigraphic datum events to magnetic polarity stratigraphy yields the following estimated magnetobiochronology of major chronostratigraphic boundaries: Cretaceous-Tertiary boundary (Chron C29R), 66.4 Ma; Paleocene-Eocene (Chron C24R), 57.8 Ma; Eocene-Oligocene (Chron C13R), 36.6 Ma; Oligocene-Miocene (Chron C6CN), 23.7 Ma. The Eocene is seen to have expanded chronologically (~ 21 m.y.) at the expense of the Paleocene (~ 9 m.y.) and is indeed the longest of the Cenozoic epochs. In addition, magnetobiostratigraphic correlations require adjustments in apparent correlations with standard marine stage boundaries in some cases (particularly in the Oligocene). Finally, we present a correlation between standard Paleogene marine and terrestrial stratigraphies.
Chronic intermittent hypoxia‐induced cardiovascular and renal dysfunction: from adaptation to maladaptation

Chronic intermittent hypoxia (CIH) is the dominant pathological feature of human obstructive sleep apnoea (OSA), which is highly prevalent and associated with cardiovascular and renal diseases. CIH causes hypertension, centred on sympathetic nervous overactivity, which persists following removal of the CIH stimulus. Molecular mechanisms contributing to CIH‐induced hypertension have been carefully delineated. However, there is a dearth of knowledge on the efficacy of interventions to ameliorate high blood pressure in established disease. CIH causes endothelial dysfunction, aberrant structural remodelling of vessels and accelerates atherosclerotic processes. Pro‐inflammatory and pro‐oxidant pathways converge on disrupted nitric oxide signalling driving vascular dysfunction. In addition, CIH has adverse effects on the myocardium, manifesting atrial fibrillation, and cardiac remodelling progressing to contractile dysfunction. Sympatho‐vagal imbalance, oxidative stress, inflammation, dysregulated HIF‐1α transcriptional responses and resultant pro‐apoptotic ER stress, calcium dysregulation, and mitochondrial dysfunction conspire to drive myocardial injury and failure. CIH elaborates direct and indirect effects in the kidney that initially contribute to the development of hypertension and later to chronic kidney disease. CIH‐induced morphological damage of the kidney is dependent on TLR4/NF‐κB/NLRP3/caspase‐1 inflammasome activation and associated pyroptosis. Emerging potential therapies related to the gut–kidney axis and blockade of aryl hydrocarbon receptors (AhR) are promising. Cardiorenal outcomes in response to intermittent hypoxia present along a continuum from adaptation to maladaptation and are dependent on the intensity and duration of exposure to intermittent hypoxia. This heterogeneity of OSA is relevant to therapeutic treatment options and we argue the need for better stratification of OSA phenotypes.
From Finite Element Simulations to Equivalent Circuit Models of Extracellular Neuronal Recording Systems Based on Planar and Mushroom Electrodes

Objective: define a new methodology to build multi-compartment lumped-elements equivalent circuit models for neuron/electrode systems. Methods: the equivalent circuit topology is derived by careful scrutiny of accurate and validated multiphysics finite-elements method (FEM) simulations that couple ion transport in the intra- and extracellular fluids, activation of the neuron membrane ion channels, and signal acquisition by the electronic readout. Results: robust and accurate circuit models are systematically derived, suited to represent the dynamics of the sensed extracellular signals over a wide range of geometrical/physical parameters (neuron and electrode sizes, electrolytic cleft thicknesses, readout input impedance, non-uniform ion channel distributions). FEM simulations point out phenomena that escape an accurate description by equivalent circuits; notably: steric effects in the thin electrolytic cleft and the impact of extracellular ion transport on the reversal potentials of the Hodgkin-Huxley neuron model. Conclusion: our multi-compartment equivalent circuits match accurately the FEM simulations. They unveil the existence of an optimum number of compartments for accurate circuit simulation. FEM simulations suggest that while steric effects are in most instances negligible, the extracellular ion transport affects the reversal potentials and consequently the recorded signal if the electrolytic cleft becomes thinner than approximately 100 nm. Significance: the proposed methodology and circuit models improve upon the existing area and point contact models. The coupling between the extracellular concentrations and reversal potential highlighted by FEM simulations emerges as a challenge for future developments in lumped-element modeling of the neuron/sensor interface.
Multidimensional compressed sensing to advance 23Na multi‐quantum coherences MRI

Sodium (23Na) multi‐quantum coherences (MQC) MRI was accelerated using three‐dimensional (3D) and a dedicated five‐dimensional (5D) compressed sensing (CS) framework for simultaneous Cartesian single (SQ) and triple quantum (TQ) sodium imaging of in vivo human brain at 3.0 and 7.0 T.
Dose–responses of seven species of cerambycid beetles to synthesized pheromones in field experiments

Adult male cerambycid beetles of the subfamilies Cerambycinae and Lamiinae emit aggregation-sex pheromones that attract both sexes, and these chemicals can be utilized for quarantine surveillance for related exotic species which produce the same or similar pheromones. Here, we assess how attraction of 7 cerambycid species to pheromone-baited traps was influenced by the release rates of synthesized pheromones from polyethylene sachet emitters. Compounds tested included racemic 3-hydroxyhexan-2-one, the (R)-enantiomer of which is the sole or major pheromone component of numerous cerambycine species, and 2 compounds that are pheromone components of many lamiine species: (E)-6,10-dimethyl-5,9-undecadien-2-yl acetate (fuscumol acetate) and 6-methylhept-5-en-2-ol (sulcatol). We confirmed release rates of these compounds could be manipulated by varying the doses loaded into emitters. Various doses and concentrations, ranging from very dilute to the neat compounds, were then tested in field trials. Several species were most strongly attracted to the highest dose of a tested compound, one species to an intermediate dose, while another species was equally attracted regardless of dose. Our results demonstrate the importance of characterizing dose–response relationships for cerambycid species targeted by pheromone-based trapping.
Participation and Its Association With Health Among Community-Dwelling Adults With Chronic Stroke

Abstract Importance: Little is known about the severity of participation restrictions among people living in the community with chronic stroke. Even less is known about the association between participation and health in this population. Objective: To describe participation among people with chronic stroke and examine the association between participation and physical and mental health. Design: Secondary analysis of baseline data from an intervention study. Setting: The parent multisite intervention study was conducted in the community, and assessments were administered in participants’ homes. Participants: Thirty-one community-dwelling adults with chronic stroke. Outcomes and Measures: Participation was measured with the Activity Card Sort (percentage of prestroke activities retained) and the Enfranchisement Scale of the Community Participation Indicators. Health was measured with the PROMIS®–29 Physical Health and Mental Health subscales. We calculated descriptive statistics for participation measures and Spearman’s ρ correlations between participation and health outcomes. Results: Participation scores were poor on all measures of participation. Most striking, 94.9% of participants retained less than 80% of their prestroke activities. All measures of participation were modestly correlated with physical health (ρ = .28–.46) and were moderately correlated with mental health (ρ = .42–.63). Conclusions and Relevance: Participation restrictions are prevalent among adults with chronic stroke, with potential implications for mental health. Stronger community-based rehabilitation and support services to enhance participation of this high-risk population are warranted. What This Article Adds: This report highlights the severity of participation restrictions among people with chronic stroke. Moreover, this report shows that people with stroke feel a lack of inclusion in the community and that participation is associated with mental and physical health.
Location: root architecture structures rhizosphere microbial associations

Abstract Root architectural phenotypes are promising targets for crop breeding, but root architectural effects on microbial associations in agricultural fields are not well understood. Architecture determines the location of microbial associations within root systems, which, when integrated with soil vertical gradients, determines the functions and the metabolic capability of rhizosphere microbial communities. We argue that variation in root architecture in crops has important implications for root exudation, microbial recruitment and function, and the decomposition and fate of root tissues and exudates. Recent research has shown that the root microbiome changes along root axes and among root classes, that root tips have a unique microbiome, and that root exudates change within the root system depending on soil physicochemical conditions. Although fresh exudates are produced in larger amounts in root tips, the rhizosphere of mature root segments also plays a role in influencing soil vertical gradients. We argue that more research is needed to understand specific root phenotypes that structure microbial associations and discuss candidate root phenotypes that may determine the location of microbial hotspots within root systems with relevance to agricultural systems.