Miracle-dz/UniFAR-FTUs huggingface dataset:
Stabilization by Means of Approximate Predictors for Systems with Delayed Input

Abstract Sufficient conditions for global stabilization of nonlinear systems with delayed input by means of approximate predictors are presented. An approximate predictor is a mapping which approximates the exact values of the stabilizing input for the corresponding system with no delay. A systematic procedure for the construction of approximate predictors is provided for globally Lipschitz systems. The resulting stabilizing feedback can be implemented by means of a dynamic distributed delay feedback law.
Frequency response of cantilever beams immersed in viscous fluids near a solid surface with applications to the atomic force microscope

Theoretical models for the frequency response of a cantilever beam immersed in a viscous fluid commonly assume that the fluid is unbounded. Experimental measurements show, however, that proximity to a surface can significantly affect the frequency response of a cantilever beam. In this article, we rigorously calculate the effect of a nearby surface on the frequency response of a cantilever beam immersed in a viscous fluid, and present a general theoretical model. Due to its practical relevance to applications of the atomic force microscope and microelectromechanical systems, detailed results are presented for cantilever beams with rectangular geometries executing flexural and torsional oscillations. It is found that dissipative loading in the fluid is primarily responsible for the observed variation in the frequency response, whereas inertial loading exerts a relatively weak influence.
Inversion climatology at San Jose, California

Abstract Month-to-month variations in the early morning surface-based and near-noon elevated inversions at San Jose, Calif. , were determined from slow rise radiosondes launched during a four-year period. A high frequency of shallow, radiative, surface-based inversions were found in winter during the early morning hours, while during the same period in summer, a low frequency of deeper based inversions arose from a combination of radiative and subsidence processes. The frequency of elevated inversions in the hours near noon was lowest during fall and spring, while inversion bases were highest and thicknesses least during these periods.
Biological and Mechanical Factors and Epigenetic Regulation Involved in Tendon Healing

Tendons are an important part of the musculoskeletal system. Connecting muscles to bones, tendons convert force into movement. Tendon injury can be acute or chronic. Noticeably, tendon healing requires a long time span and includes inflammation, proliferation, and remodeling processes. The mismatch between endogenous and exogenous healing may lead to adhesion causing further negative effects. Management of tendon injuries and complications such as subsequent adhesion formation are still challenges for clinicians. Due to numerous factors, tendon healing is a complex process. This review introduces the role of various biological and mechanical factors and epigenetic regulation processes involved in tendon healing.
Effectiveness of Adding Docetaxel to Androgen Deprivation Therapy for Metastatic Hormone-Sensitive Prostate Cancer in Korean Real-World Practice

Purpose Evidence in favor of adding docetaxel in treatment of metastatic hormone-sensitive prostate cancer (mHSPC) has led to docetaxel in conjunction with androgen deprivation therapy (ADT) as standard therapy. The aim of this study was to examine the effectiveness of docetaxel with ADT for Korean patients with mHSPC in real-world practice. Materials and Methods A retrospective cohort study was performed at six Korean hospitals for patients with mHSPC treated with docetaxel plus ADT. Patients were treated every 3 weeks for up to six cycles with 75 mg/m2 of docetaxel. The primary endpoint was time to castration resistant prostate cancer (CRPC). Results This study included 46 eligible patients from June 2016 to February 2021. Median age was 68.5 years (range, 52–84) and all patients present with de novo M1 with high-volume disease. The median prostate-specific antigen (PSA) level at ADT initiation was 205.4 (7.7–1933) ng/mL, and time from ADT to docetaxel was 2.4 months (0–5.3). All six planned cycles of docetaxel were delivered in 36 patients (78%), 7 patients (15%) discontinued treatment due to adverse events, and 3 patients (7%) discontinued due to progression. At the time of the analysis, CRPC had developed in 34 patients (74%), and the median time to CRPC was 18.0 (95% confidence interval, 14.1–21.9) months. PSA <0.2 ng/mL was achieved in 11 patients (24%) after 6 months of ADT and in 10 patients (22%) after 12 months. At last follow-up, 35 patients (76%) were alive; the median overall survival was not reached. Conclusion The effect of docetaxel combined with ADT for Korean patients with mHSPC is comparable with prior results in Western studies.
Social networks and consumer technology usage: A systematic literature review and future research directions

Abstract Prior research on social networks and consumer technology usage has used diverse theoretical frameworks to study the extent to which social networks, in their various forms, are related to consumer technology usage. However, the adoption and utilization of these theoretical frameworks has led to fragmentation of findings, and a lack of consistency in the conceptualization and operationalization of key social network constructs. There is, therefore, a need for a comprehensive systematic review of studies on the interrelations between social networks and consumer technology usage, with a view to identifying the common areas of focus, major weaknesses, emerging trends, and directions for future research. Using the Population, Intervention, Comparison, Outcomes (PICO) framework, this paper relies on five research questions to examine the various frameworks that have been used to study social networks in relation to consumer technology usage, as well as their shortcomings in terms of consistency in conceptual frameworks, the research contexts commonly studied, areas of study focus as well as emerging trends. The paper concludes by proposing future areas of research, which include: the development of a theoretical framework to guide the study of the relationship between social networks and consumer technology usage; the moderating roles of consumer demographic characteristics; the mediating role of consumer behavioral characteristics; and the influence of technology-enabled social networks in conditioning consumer attitude towards technology and consumer technology usage in different contexts.
Characterization of Gemini near-IR arrays

Four ALADDIN Type II 1024 X 1024 InSb arrays have been tested in the NOAO IR Detector Lab for use in the Gemini IR instruments; the Gemini Near-IR Spectrometer, and the near IR imager. Santa Barbara Research Center has been able to successfully deliver science devices. The best of which will be selected for use at Mauna Kea and Cerro Pachon. These results are reported to show the progress in the development of these arrays.
Stability margins of singular perturbation systems via state-feedback control

The gain and phase margins of singular perturbation systems are analysed under unmodelled high-frequency dynamics control, composite control, and the original full-order linear quadratic (LQ) control. The analysis is on the basis that there is a good relation between the minimum singular value of return difference transfer matrix and the stability margins. We begin with the examination of stability margins of subsystems and then show that state-feedback control design of subsystems could preserve gain and phase margins for the original full-order singularly perturbed system if the singular perturbation parameter epsiv; is sufficiently small. The effectiveness of e on stability margins is formulated and determined. It is found that the effectiveness can be evaluated by a simple method. Two examples are exploited to illustrate the analytic results.
Numerical Analysis of Magnetic Nanoparticles Penetration within the Cancerous Tumor Tissue under Influence of External Magnet

Using the great magnetic drug carriers (MDCs) is proposed mechanism to reduce and increase the toxic drugs penetration within the healthy and cancerous tissues, respectively. The purpose of current study is to investigate the penetration of magnetic drug carriers within the cancerous tumor tissue under the influence of external magnet. In order to solve the coupled governing equations an in house finite volume based code is developed and utilized. Capillary wall and tumor tissue is modelled as a saturated porous media. Results show the penetration of MDCs into the tumor in the absence of magnetic field is minimal and is limited to the surface of the tumor. On the other hand, under the influence of external magnet the penetration of MDCs within the tumor increases exponentially.
Use of zinc iodide solutions in flow research

The advantages of using transparent flow boundaries and liquids with matched index of refraction are demonstrated for internal flow research, when the internal boundaries of the flow are of complicated shape. In particular, a new technique involving aqueous solutions of zinc iodide is described, as applied to the study of secondary flows in aerodynamic devices used in ink jet printing. Zinc iodide solutions offer large freedom in the choice of index of refraction, without being excessively viscous. When used in conjunction with transparent conducting electrodes, the solutions afford internal electrochromic flow visualization as well. The electrochromic property is demonstrated for the case of classical circular Couette flow. In contrast with many other candidate liquids, zinc iodide solutions are safe and compatible with transparent plastics. These properties extend the scope of optical flow diagnostics, such as laser Doppler velocimetry.
Interruptibility of Speech

We have conducted a preliminary set of experiments on the ability of a speaker to interrupt himself when given a cue to do so at unexpected moments. Subjects were asked to repeat short utterances, each containing only one primary stress, at a fixed rhythm determined by a metronome. Contrary to our expectations, we did not find any particular point in these utterances when a speaker finds it harder to stop saying what he originally intended to say and start saying something else instead. Subjects were able to respond about 350 msec after the presentation of the cue (a 1‐kHz tone), irrespective of where in the utterance the cue was presented. But when the cue was presented not within but just before the utterance, subjects took far longer (up to 750 msec) to respond. It is hypothesized that while a speaker is planning the articulations for a short utterance (in this case a single stress group), there is a period during which he cannot readily plan another utterance. [Research supported by ONR. ]
A 16 GB 1024 GB/s HBM3 DRAM With Source-Synchronized Bus Design and On-Die Error Control Scheme for Enhanced RAS Features

This article proposes practical design techniques to enhance performance and reliability of 1024 GB/s high-bandwidth memory-3 (HBM3). Effective data-bus design methods are applied to transfer data from multi-bank to a data-bus with a sufficient data fetch margin. A symbol-based on-die error-correcting code (OD-ECC) to correct a 16-bit error, bounded by a sub-wordline (WL), and parallelized data-bus inversion (DBI) are implemented. Error check and scrub (ECS) mode and repair capability check (RCC) mode with an internal serial interface are designed to support system reliability, availability, and serviceability (RAS). A memory built-in self-test (MBIST) provides a unified at-speed test with programmability based on test-set units (TUs). A 16 GB HBM3 fabricated in the third generation of the 10 nm class DRAM process achieves a bandwidth up to 1024 GB/s (8 Gb/s/pin) and provides stable operation at a high temperature (e.g., 105 °C) while improving an error detection rate by 92.2%.
The number of apparent double points of certain loci

1. A sketch of the first part of this paper, together with some of the second part, was first written out in October last, shortly after the publication of Mr Babbage's paper, A series of rational loci with one apparent double point. It is well known that the Del Pezzo quintic surface the only non-ruled quintic surface in [5], has one apparent double point; Babbage shows that this surface is a member of a series of loci in [2n + 1], each of which has one apparent double point; he establishes the existence of these loci from their representations on flat spaces ∑n, these representations being analogous to the plane representation of by means of cubic curves through four fixed points.
MCP-1 plays a critical role in neutrophil function and pyroptosis during Carbapenemf-Resistant Klebsiella Pneumoniae

Monocyte chemoattractant protein-1 (MCP-1) is important for monocyte recruitment to the lungs in response to bacterial infection. MCP-1 is also essential for protective neutrophil recruitment to the lungs during Escherichia coli pneumoniae infection. Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection has been rapidly growing as a life-threatening nosocomial disease in many countries. Little is known regarding the role of chemokines and early cellular immune responses in protective immunity to pulmonary infection with CRKP. In the current study, we investigated the role of MCP-1 in pulmonary innate immunity against CRKP infection in C57Bl/6 mice and MCP-1−/− mice. MCP-1 appears to be essential for restricting bacterial outgrowth and death in mice. Compared to the C57Bl/6 mice, MCP-1−/− mice showed reduced influx of neutrophils in the airways and lung parenchyma, as assessed by nucleated cell concentrations in BALF and myeloperoxidase activity (MPO) in lung tissue. Moreover, the neutrophil extracellular traps (NETs) induced by CRKP were reduced in MCP-1−/− mice in both in vitro and in vivo experiments. Intriguingly, subsequent to CRKP infection, MCP-1−/− mice demonstrated increased pyroptosis through higher expression of IL-1β and cleaved gasdermin-d in the lung. These findings enhance our understanding of the critical role of MCP-1 in modulating neutrophil function and pyroptosis in neutrophils and suggest that therapies targeting modulation of NETs and pyroptosis during CRKP infection should be explored.
Preparation, Identification and Application of β-Lactoglobulin Hydrolysates with Oral Immune Tolerance

To reveal, for the first time, the mechanism of T cell epitope release from β-lactoglobulin that induces oral immune tolerance, a strategy for the prediction, preparation, identification and application of β-lactoglobulin hydrolysate with oral immune tolerance was established using the bioinformatics method, hydrolysis, mass spectrometry, T cell proliferation assays and animal experiments. Some T cell epitope peptides of β-lactoglobulin were identified for the first time. The hydrolysates of trypsin, protamex and papain showed oral tolerance, among which the hydrolysates of protamex and papain have been reported for the first time. Although the neutral protease hydrolysate contained T cell epitopes, it still had allergenicity. The mechanism behind oral immune tolerance induction by T cell epitopes needs to be further revealed. In addition, the trypsin hydrolysate with abundant T cell epitopes was added to whey protein to prepare the product for oral immune tolerance. Overall, this study provides insights into the development of new anti-allergic milk-based products and their application in the clinical treatment of milk allergies.
Challenges and exploration for immunotherapies targeting cold colorectal cancer

In recent years, immune checkpoint inhibitors (ICIs) have made significant breakthroughs in the treatment of various tumors, greatly improving clinical efficacy. As the fifth most common antitumor treatment strategy for patients with solid tumors after surgery, chemotherapy, radiotherapy and targeted therapy, the therapeutic response to ICIs largely depends on the number and spatial distribution of effector T cells that can effectively identify and kill tumor cells, features that are also important when distinguishing malignant tumors from “cold tumors” or “hot tumors”. At present, only a small proportion of colorectal cancer (CRC) patients with deficient mismatch repair (dMMR) or who are microsatellite instability-high (MSI-H) can benefit from ICI treatments because these patients have the characteristics of a “hot tumor”, with a high tumor mutational burden (TMB) and massive immune cell infiltration, making the tumor more easily recognized by the immune system. In contrast, a majority of CRC patients with proficient MMR (pMMR) or who are microsatellite stable (MSS) have a low TMB, lack immune cell infiltration, and have almost no response to immune monotherapy; thus, these tumors are “cold”. The greatest challenge today is how to improve the immunotherapy response of “cold tumor” patients. With the development of clinical research, immunotherapies combined with other treatment strategies (such as targeted therapy, chemotherapy, and radiotherapy) have now become potentially effective clinical strategies and research hotspots. Therefore, the question of how to promote the transformation of “cold tumors” to “hot tumors” and break through the bottleneck of immunotherapy for cold tumors in CRC patients urgently requires consideration. Only by developing an in-depth understanding of the immunotherapy mechanisms of cold CRCs can we screen out the immunotherapy-dominant groups and explore the most suitable treatment options for individuals to improve therapeutic efficacy.
Hybrid Chlorides with Methylhydrazinium Cation: [CH3NH2NH2]CdCl3 and Jahn-Teller Distorted [CH3NH2NH2]CuCl3

The synthesis, structural, phonon, optical, and magnetic properties of two hybrid organic-inorganic chlorides with monoprotonated methylhydrazinium cations (CH3NH2NH2+, MHy+), [CH3NH2NH2]CdCl3 (MHyCdCl3), and [CH3NH2NH2]CuCl3 (MHyCuCl3), are reported. In contrast to previously reported MHyMIICl3 (MII = Mn2+, Ni2+, and Co2+) analogues, neither compound undergoes phase transitions. The MHyCuCl3 has a crystal structure familiar to previous crystals composed of edge-shared 1D chains of the [CuCl5N] octahedra. MHyCuCl3 crystallizes in monoclinic P21/c symmetry with MHy+ cations directly linked to the Cu2+ ions. The MHyCdCl3 analogue crystallizes in lower triclinic symmetry with zig-zag chains of the edge-shared [CdCl6] octahedra. The absence of phase transitions is investigated and discussed. It is connected with slightly stronger hydrogen bonding between cations and the copper–chloride chains in MHyCuCl3 due to the strong Jahn–Teller effect causing the octahedra to elongate, resulting in a better fit of cations in the accessible space between chains. The absence of structural transformation in MHyCdCl3 is due to intermolecular hydrogen bonding between two neighboring MHy+ cations, which has never been reported for MHy+-based hybrid halides. Optical investigations revealed that the bandgaps in Cu2+ and Cd2+ analogues are 2.62 and 5.57 eV, respectively. Magnetic tests indicated that MHyCuCl3 has smeared antiferromagnetic ordering at 4.8 K.
Transport and Confinement of Plumes From Tropopause‐Overshooting Convection Over the Contiguous United States During the Warm Season

Tropopause‐penetrating overshooting convection (OC) can transport tropospheric air into and affect the composition of the lower stratosphere. During the warm season, OC occurs frequently over the contiguous United States, and the transport of plumes from these events is modulated by the flow over North America, which throughout June to August is characterized by a large‐scale anticyclone in the upper troposphere and lower stratosphere. This study uses data from the Next Generation Weather Radar and the ERA5 reanalysis to locate OC during May–August of 2008–2020. Evidence of convective transport is found well above the 380 K isentrope, which is the top of the “lowermost stratosphere” and also the top of the stratospheric middleworld. By initializing massless particles within the volume of OC above the tropopause, we perform trajectory calculations to simulate the transport of OC plumes. With three‐dimensional diabatic trajectory modeling in isentropic coordinates using winds from ERA5, we quantify the confinement within the anticyclone and the number of trajectories transported into the tropical and extratropical stratosphere. By evaluating the trajectory residence time in the North American region, we find that July exhibits the strongest confinement, with about a quarter of trajectories staying in the region for more than 11 days. It is shown that, together with sufficient injection height, convective injection that occurs south of the jet and/or into anticyclonic regimes increases the chances of air remaining in the stratosphere. After 30 days, 45% of all air masses injected above the tropopause remain in the global stratosphere.
Cancer and Associated Recent Findings on Metastasis

Background: Cancer is one of the disease with up rised constant mutations and difficult to cure due to metastatic tumors and cell- cell communications between the tumors and the cell through stromal microenvironment and cell signaling. Discussion: Integrin α11β1 acts as a stromal receptor and remodifies collagen through communication between the stroma and collagen related genes contributing majorly to metastasis in NSCLC. Extracellular matrix protein-1, Osteopontin and Osteonectin are the secreted proteins which are differentially expressed based on the metastatic phenotype. Thrombospondin-1 is responsible for migratory property of the wild cells by promoting intravasation and hyperplasia in many cancers like prostate cancer. Hemopexin and Ferritin light chain (FTL) are the proteins majorly expressed in cancer cell cytoplasm and stromal fibroblasts and contribute to metastasis through secretions mediated by extracellular vesicles. Conclusion: Other proteins like TWIST, BRCA-1, BRCA-2, cell adhesion proteins, MMPs, Tetraspanin can contribute to metastasis in cancer through promoting either cell migration, Extravasation, Hyperplasia or Angiogenesis facilitating the secondary tumor formation in distant organs.
Multisource electrohydraulic servo valve fault status diagnostic algorithm based on a message propagation mechanism

Fault identification of electrohydraulic servo valves is crucial to maintain the reliability and safety of high-precision electrohydraulic servo systems. Because the nonlinear characteristics and fault characteristics of electrohydraulic servo systems under noise conditions are implicit, it is difficult to obtain a large number of fault data of electrohydraulic servo valves. Therefore, an electrohydraulic servo valve fault diagnosis model based on characteristic distillation is proposed in this paper. First, the original fault data model is obtained based on an electrohydraulic servo valve fault test platform, the data are standardized, and the data of more than one cycle are extracted using a combination of down sampling and a sliding window for data enhancement. Second, a neural network fault diagnosis algorithm based on stack graph convolution is proposed, which is suitable for detecting different types of states (normal state, wear state, stuck state and coil short-circuit state) of electrohydraulic servo valves. The accuracy of the test set fluctuates between 0.7 and 1.0. Then, because there is a certain relationship between the characteristic smoothing phenomenon of a stack graph convolution model and the number of layers, a multilayer stack graph convolution model is bound to have problems such as model degradation. Therefore, a residual model is introduced into the stack model to improve the convergence speed of the model during the optimization process. The results show that the average accuracy of this method is 100%.