Miracle-dz/UniFAR-FTUs huggingface dataset:
What Is the Inﬂuence of Weight Change on Forearm Bone Mineral Density in Peri- and Postmenopausal Women? The Health Study of Nord-Trøndelag, Norway

Weight loss in the elderly increases bone loss and the risk of fractures, especially at the hip and spine. The inﬂuence of weight change on non-weight-bearing parts of the skeleton is less well known. The purpose of this study was to investigate an association between weight change during the peri- and postmenopausal years and forearm bone mineral density (BMD). Among 8,856 women aged 45–60 years attending the ﬁrst Health Study of Nord-Trøndelag, Norway (HUNT I, 1984–1986), a random sample of 2,795 women was invited to forearm densitometry (single x-ray absorptiometry technology) at HUNT II (1995–1997), after a mean period of 11.3 years. A total of 2,005 women (mean age: 65.1 years) were eligible. The mean weight had increased 3.4 kg; the gain was greater in the youngest women. A total of 382 women (19.1%) had lost and 1,331 women (66.3%) had gained weight. Weight change explained little of the BMD variance, 0.7% and 0.4% for weight loss and weight gain, respectively. Weight loss was an independent and statistically signiﬁcant negative predictor of BMD, adjusted for body weight, age, age at menopause, smoking, and ovarian hormone treatment, particularly among women with a baseline body mass index greater than 25 kg/m 2 . No independent association between weight gain and forearm BMD was found.
Delineation of molecular ndings by whole exome sequencing for suspected cases of paediatric-onset mitochondrial diseases in the Southern Chinese population

Mandy Ho-Yin Tsang HKU Anna Ka-Yee Kwong University of Hong Kong Kate Lok-San Chan University of Hong Kong Jasmine Lee-Fong Fung University of Hong Kong Mullin Ho-Chung Yu University of Hong Kong Christopher Chun-Yu Mak University of Hong Kong Kit-San Yeung University of Hong Kong Richard J.T. Rodenburg Radboud center for mitochondrial disease Jam A.M. Smeitink Radboud Center for mitochondrial disease Rachel Chan Centro Hospitalar Conde de Sao Januario Thomas Tsoi Centro Hospitalar Conde de Sao Januario Joannie Hui Hong Kong Children's Hospital Sheila Suet-Na Wong Hong Kong Children's Hospital Shuk-Mui Tai Pamela Youde Nethersole Eastern Hospital Victor Chi-Man Chan Pamela Youde Nethersole Eastern Hospital Che-Kwan Ma United Christian Hospital Tsiu-Hang Sharon Fung Kwong Wah Hospital Shun-Ping Wu Queen Elizabeth Hospital WK Chan Tuen Mun Hospital Brian Hon-Yin Chung (  bhychung@hku.hk ) University of Hong Kong Cheuk-wing Fung University of Hong Kong
DISMOUNTED SOLDIER AUTONOMY TOOLS (DSAT) – FROM CONCEPTION TO DEPLOYMENT

The Dismounted Soldier Autonomy Tools (DSAT) program is the result of the evolution and reuse of work from multiple industry Internal Research & Development (IR&D) programs, as well as work stemming from various multi-service investments made over the past several years. The DSAT program is a direct offshoot of MARTI (Mobile Autonomous Robotics Technology Initiative) a 5 year IR&D program at Southwest Research Institute (SwRI) from 2006-2011 that created a foundation for autonomy and on road capability. The MARTI work was subsequently leveraged into the Office of Naval Research (ONR) Code 30 SUMET (Small Unit Mobility Enhancement Technologies) program starting in 2009. The DSAT program builds off of these SwRI efforts, as well as previous work by TARDEC and DCS Corp in the areas of vehicle architectures and warrior-machine interfaces to build a consolidated, coordinated program. Working together, the team has made several improvements to the collective code base, resulting in new capabilities and increased modularity for new development. Through this Government/Industry collaboration, the DSAT program is able to maximize multi-service DoD spending by leveraging these previous investments and sharing technologies and capabilities among the ongoing TARDEC and ONR Code 30 multi-team development activities.
PPA_A_325851 1755..1762

1School of Pharmacy, Monash University Malaysia, Selangor, 47500, Malaysia; 2College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Australia; 3Department of Pharmacy Practice, College of Pharmacy, Qassim University, Buraidah, Qassim, Saudi Arabia; 4Biofunctional Molecule Exploratory (BMEX) Research Group, School of Pharmacy, Monash University Malaysia, Bandar Sunway, 47500, Malaysia; 5College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, People's Republic of China; 6College of Pharmacy, QU Health, Qatar University, Doha, Qatar; 7Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, Pakistan Purpose: The aims of this study are to explore the types and patterns of use of health mobile apps among pharmacy clients in Selangor, Malaysia, and to explore the users’ experiences and views regarding the benefits of and issues with the use of the health apps. Patients and Methods: A cross-sectional survey was conducted with 278 pharmacy clients who were using health apps on their smartphones. A survey was developed, piloted, and rolled out, comprised of socio-demographic characteristics, information regarding the common types and the pattern of health app use, the benefits of health apps, and issues that users faced while using these apps. Statistical analysis was performed using IBM SPSS version 21. Results: The mean (±SD) age of health app users was 29.8 (±11.74) years old, and over half of them (51.8%) were male, while less than half were female (48.2%). There were 48 different types of mobile health apps used by the participants in this study. The two most common were multi-purpose general health apps (53.6%) and fitness apps (38.1%). In terms of pattern of use, 33.5% of the participants reported using their health apps daily, 36.7% at least once weekly, and 25.2% monthly. The main benefits reported by the users were tracking of health status (47%), motivation (41%), and knowledge about health and fitness (9%). The main issues reported by the participants included inaccuracy of the app (24%), inconvenience (20.7%), and not being user-friendly (18.5%). Conclusion: The study showed that the participants used many different types of mobile health apps for several purposes, including general health, wellness, fitness, and selfmanagement of diseases. These apps helped the participants to track their health-related activities and motivated them to maintain their wellness and fitness. Further areas of improvement were identified to ensure evidence-based and effective utilization of apps to achieve required health outcomes.
A user configurable voice based controller for Midi synthesizer

Through the research we undertook for this master thesis, we developed a prototype, which we believe is the first step, towards building a voice-based controller for a midi synthesizer to be used in real-time. A key component of this research was the evaluation of the different onsets detection algorithms, and their applicability to the prototype developed herein. Another focus of the research was the smoothing of the fundamental frequency estimates, produced by the YIN algorithm. As a result of the research undertaken, we have found that an onset detection method based on the estimated note changes was more robust to background noise. Our prototype is developed in Max/Msp environment, which renders our prototype open to changes by its user, and make it useful with most software midi synthesizer.
DDDT_A_327238 4713..4732

1Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; 2Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan; 3Medical and Bio-Allied Health Sciences Research Centre, Ajman University, Ajman, United Arab Emirates; 4Department of Clinical Sciences, Ajman University, Ajman, 346, United Arab Emirates; 5Department of Clinical Sciences, College of Pharmacy, Al-Ain University of Science and Technology, Abu Dhabi, United Arab Emirates; 6Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore, 54000, Pakistan Abstract: Polyphenols have long been recognized as health-promoting entities, including beneficial effects on cardiovascular disease, but their reputation has been boosted recently following a number of encouraging clinical studies in multiple chronic pathologies, that seem to validate efficacy. Health benefits of polyphenols have been linked to their well-established powerful antioxidant activity. This review aims to provide comprehensive and up-to-date knowledge on the current therapeutic status of polyphenols having sufficient heed towards the treatment of cardiovascular diseases. Furthermore, data about the safety profile of highly efficacious polyphenols has also been investigated to further enhance their role in cardiac abnormalities. Evidence is presented to support the action of phenolic derivatives against cardiovascular pathologies by following receptors and signaling pathways which ultimately cause changes in endogenous antioxidant, antiplatelet, vasodilatory, and anti-inflammatory activities. In addition, in vitro antioxidant and pre-clinical and clinical experiments on antiinflammatory as well as immunomodulatory attributes of polyphenols have revealed their role as cardioprotective agents. However, an obvious shortage of in vivo studies related to dose selection and toxicity of polyphenols makes these compounds a suitable target for clinical investigations. Further studies are needed for the development of safe and potent herbal products against cardiovascular diseases. The novelty of this review is to provide comprehensive knowledge on polyphenols safety and their health claims. It will help researchers to identify those moieties which likely exert protective and therapeutic effects towards cardiovascular diseases.
OTT_A_234549 2855..2872

Center for Drug Metabolism and Pharmacokinetics, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, People’s Republic of China Abstract: MicroRNAs (miRNAs) are a class of endogenous non-coding single-stranded small-molecule RNAs that regulate gene expression by repressing target messenger RNA (mRNA) translation or degrading mRNA. miR-34a is one of the most important miRNAs participating in various physiological and pathological processes. miR-34a is abnormally expressed in a variety of tumors. The roles of miR-34a in gastrointestinal cancer (GIC) draw lots of attention. Numerous studies have demonstrated that dysregulated miR-34a is closely related to the proliferation, differentiation, migration, and invasion of tumor cells, as well as the diagnosis, prognosis, treatment, and chemo-resistance of tumors. Thus, we systematically reviewed the abnormal expression and regulatory roles of miR-34a in GICs including esophageal cancer (EC), gastric cancer (GC), colorectal cancer (CRC), hepatocellular carcinoma (HCC), pancreatic cancer (PC), and gallbladder cancer (GBC). It may provide a profile of versatile roles of miR-34a in GICs.
A Verification Framework for Business Rules Management in the Dutch Government Context

—Since an increasing amount of business decision/logic management solutions are utilized, organizations search for guidance to design such solutions. An important aspect of such a solution is the ability to guard the quality of the specified or modified business decisions and underlying business logic to ensure logical soundness. This particular capability is referred to as verification. As an increasing amount of organizations adopt the new Decision Management and Notation (DMN) standard, introduced in September 2015, it is essential that organizations are able to guard the logical soundness of their business decisions and business logic with the help of certain verification capabilities. However, the current knowledge base regarding verification as a capability is not yet researched in relation to the new DMN standard. In this paper, we re-address and - present our earlier work on the identification of 28 verification capabilities applied by the Dutch government [1]. Yet, we extended the previous research with more detailed descriptions of the related literature, findings, and results, which provide a grounded basis from which further, empirical, research on verification capabilities with regards to business decisions and business logic can be explored.
Full Reviews Who regenerates the kidney tubule?

The kidney possesses profound regenerative potential and in some cases can recover completely ‘ restitutio at integrum ’ following an acute kidney injury (AKI). Emerging evidence strongly suggests that sometimes repair is incomplete, however, and, in this situation, an episode of AKI leads to future chronic kidney disease (CKD). Understanding the tubular response after AKI will shed light on the relationship between incomplete repair and future risk of CKD. The ﬁ rst repair phase after AKI is characterized by robust proliferation of epithelial cells in the proximal tubule. The exact source of these proliferating cells has been a source of controversy for the last decade. While nearly everyone now agrees that reparative cells arise within the proximal tubule, there is disagreement about whether all surviving cells possess an equivalent repair capacity through dedifferentiation, or alternatively whether a pre-existing intratubular stem cell population [so-called scattered tubular cells (STC)] is responsible for repair. This review will summarize the evidence on both sides of this issue and will discuss very recent genetic fate-tracing data that strongly points against the existence of intratubular stem cells but rather indicates that terminally differentiated proximal tubule epithelial cells undergo dedifferentiation upon injury to replace lost neighboring tubular epithelial cells through proliferative self-duplication. This new evidence includes data clearly indicating that STC are not committed tubular stem cells but instead represent individual dedifferentiated tubular epithelial cells that transiently express putative stem cell markers. ABSTRACT The discovery of novel classes of non-coding RNAs (ncRNAs) has revolutionized medicine. Long thought to be a mere cellular housekeeper, surprising functions have recently been uncovered. MicroRNAs (miRNAs), are a representative of the class of short ncRNAs, play afundamental role in the control of DNA and protein biosynthesis and activity as well as pathology. Currently, miRNAs are being investigated as diagnostic and prognostic markers and potential therapeutic targets in kidney transplantation for such indolent processes as ischaemia-reperfusion injury, humoral rejection or viral infections. It is realistic to believe that monitoring of renal allograft recipients in the future will include genome-wide miRNA pro ﬁ ling of biological ﬂ uids. Based on these individual pro ﬁ les, an informed decision on therapeutic consequences will be possible. A ﬁ rst success with a speci ﬁ c suppression of miRNAs
A deep UBVRI CCD photometric study of the moderately young Southern open star cluster NGC 4755 = κ Crucis

CCD observations in U, B, V, R and I passbands have been used to generate (U-B), (B-V) colour-colour and deep V, (B-V); V, (U-B) and V, (V-I) colour-magnitude diagrams for the young open cluster NGC 4755. The sample consists of 813 stars reaching down to V ~20mag. There appears to be non-uniform extinction over the face of the cluster with a mean value of E(B-V)=0.41mag and a range of about 0.05mag. The true distance modulus to the cluster has been estimated as 11.6±0.2mag. An age of ~10Myr has been assigned to the post-main sequence (MS) cluster members. Ages of the post-MS and pre-MS stars indicate that massive (M > 10 M ⊙ ) and low mass (M ⊙ ) stars in the cluster are formed nearly at the same time from a molecular cloud which might have existed for a minimum period of about 6-7Myr.
Evaluating the Role of Age in Language Acquisition

: The importance of age in language learning has been debated for a long time. The general assumption is that age plays a positive role in facilitating language learning and attaining native-like competence. This paper is concerned mainly with investigating the role which age plays in mastering syntax/morphology and phonology in the process of language learning. It also pays some attention to the effects of age on the route or the way and the rate or the amount of learning. Studies carried out earlier on the effects of age are reviewed in this paper. It reviews how age affects learning and what aspects of language it affects focusing on syntax/ morphology and phonology. It is concluded that age mainly affects phonology. That is, starting to learn a language early leads to native-like pronunciation. However, it is found that an early start is not an advantage for learning syntax and morphology. It is recommended that language be introduced early in curriculums so learners make more benefit from early start to master the target language.
Measurements of Unattached and Attached RaA Atoms in AtmosPhere and Their Deposition in Human Respiratory Tract

For evaluating the unattached fraction f (fraction of RaA atoms unattached on aerosols) in the open air, the total activities and the unattached activities of RaA atoms have been measured in various environments. The observation of the fraction g (fraction of neutral RaA atoms among unattached RaA atoms), and the number concentration Z and mean radius of aerosols have also been carried out simultaneously. The observed values of f and g were 0.1~1.0 and 0.65± 0.16, respectively. The inverse correlation between f and Z has been observed and discussed theoretically taking account of the fraction g and mean radius of aerosols. The Gormley & Kennedy formula was used for estimating the deposition fraction of unattached RaA atoms in the human respiratory tract, and the Takahashi & Ito model was applied for attached RaA atoms. The calculated results showed that unattached RaA atoms were deposited in the "upper respiratory passages" and attached ones in the "lower respiratory passages", and that the regional distribution of deposited RaA atoms depended markedly on f.
The Impact of Organizational Learning on Employees' Innovative Behavior: Moderating Effects of Emotional Commitment

The development and innovation of an enterprise are closely linked, and the innovation of an enterprise is based on employee innovation. At present, the living environment of enterprises is changing with each passing day, and competition is becoming increasingly fierce. In order to survive in a competitive environment, companies need to have sufficient innovation capabilities to compete with competitors. Enterprise innovation is inseparable from learning. Only through the learning and transformation of knowledge can employees' innovation level be enhanced. This study assumes that emotional commitment plays a moderating role in the organizational learning climate affecting employee innovation. At the same time, The research selects more than 80% of employees in a telecommunications company as a survey sample, and uses descriptive analysis and regression analysis to verify the significance of emotional commitment in regulating the organizational learning atmosphere and employee innovation behavior. It is found through research that the organizational learning atmosphere and emotional commitment of employees can positively affect employees' innovative behavior. Emotional commitment can also regulate the organizational learning atmosphere and employee's innovative behavior, and this relationship is relatively significant. The purpose of this study is to explore how to improve the innovation behavior of employees, improve the innovation performance of enterprises, provide management suggestions for enterprises, and promote the long-term development of enterprises.
Mean Field Linear-Quadratic-Gaussian (LQG) Games: Major and Minor Players

This paper is concerned with a backward-forward stochastic differential equation (BFSDE) system, in which a large number of negligible agents are coupled in their dynamics via state average. Here some BSDE is introduced as the dynamics of major player, while dynamics of minor players are described by SDEs. Some auxiliary mean-field SDEs (MFSDEs) and a $3\times2$ mixed forward-backward stochastic differential equation (FBSDE) system are considered and analyzed instead of involving the fixed-point analysis as in other mean-field games. We also derive the decentralized strategies which are shown to satisfy the $\epsilon$-Nash equilibrium property.
The Determinants of Firms’ Investments in the Manufacturing Sector: What Role for Macroeconomic Policies?

Low investment rates are the key problem of development. Adverse macroeconomic conditions are often identified as the main causes of low investments in developing countries. This paper contributes to the debate of what macroeconomic conditions spur investments. It investigates how firms adjust their investments to macroeconomic conditions and if these macroeconomic conditions explain differences in firms’ investments rates between countries. Using data from World Bank Enterprise Surveys, we estimate a multilevel Heckman selection model of firms’ investment decisions. The findings of this paper suggest that macroeconomic conditions are important determinants of firms’ investments but matter more as within country variations than as between countries variations. This means that firms’ investment choices are not affected by structural macroeconomic conditions, but follow business cycles’ fluctuations. This investigates the effect of macroeconomic policies on firms’ investment decisions. Policy areas of interest can be summarized the following headings: macroeconomic stability; financial reforms; estimating a multilevel Heckman selection model of firms’ investments in developing countries from 2002 to 2010. The paper is novel in various aspects. One
Usefulness of echocardiography in athletes: experience of a Portuguese center

Introduction: Pre-participation screening aimed at the detection of disorders associated with sudden cardiac death is universally supported by major medical societies. However, the best method for screening remains controversial. The aim of this study was to evaluate the prevalence of structural cardiac lesions identified by echocardiography in apparently healthy athletes referred for pre-participation screening. Material and methods: We conducted an observational retrospective study (January 2017-December 2019) performed in a single center. We evaluated echocardiograms of athletes under 35 years of age, performed in the first evaluation for pre-participation screening. Results: A total of 1,981 different athletes’ echocardiograms were included; 36 exams (1.8%) reported structural cardiac lesions. The most common cardiac lesions found were mitral valve prolapse (n = 5), atrial septal aneurysm (n = 5) and atrial septal defect (n = 4). The bicuspid aortic valve and left ventricular hypertrophy were each present in 3 athletes (n = 3); ventricular septal defects, left ventricular noncompaction, aortic dilatation and dilated cardiomyopathy were each found in 2 athletes (n = 2). Less frequent lesions were present in only one athlete, such as hypertrophic cardiomyopathy, surgically-corrected transposition of the great arteries, and pulmonary valve stenosis. Notably, among 36 patients with structural abnormalities in echocardiography, only 6 (16.7%) had positive standard pre-participation screening (combining personal and family history, physical examination and electrocardiogram). Conclusions: Echocardiography plays an important role in detecting cardiac structural abnormalities that would otherwise escape standard screening protocols and could be left unnoticed. This study suggests a potential benefit of including echocardiography in the first evaluation for pre-participation screening of competitive athletes. Português J experience of a Cardiovasc 33