Miracle-dz/UniFAR-FTUs huggingface dataset:
Observations of the chemical composition of stratospheric aerosol particles

Recent instrumentation can distinguish various types of aerosol particles in the stratosphere and determine their relative abundance. In the background lower stratosphere between major volcanic eruptions, most particles are either relatively pure sulphuric acid, sulphuric acid with material from ablated meteoroids or mixed organic‐sulphate particles that originated in the troposphere. The meteoritic iron and magnesium appear to be dissolved whereas the aluminum and silicon appear to be inclusions. Most stratospheric aerosol mass is liquid sulphuric acid and associated water, but a large fraction of particles contain either inclusions of meteoritic elements such as silicon or organic material that is probably effloresced or glassy. These solid phases could have large but unknown implications for the ability of particles to act as freezing nuclei for polar stratospheric clouds. Internally mixed black carbon is a measurable but very small component of the stratospheric aerosol by mass. Despite their importance for heterogeneous chemistry, there are few quantitative measurements of halogens in stratospheric particles.
Exploring the Multi-Faceted Role of Sirtuins in Glioblastoma Pathogenesis and Targeting Options

Recent advances in glioblastoma (GB) research have shed light on the molecular characteristics, the defected intracellular signaling pathways, and the genetic and epigenetic alterations involved in their pathogenesis. Despite constant efforts, GB remains an aggressive malignant tumor with limited therapeutic approaches, poor prognosis, and a low survival rate. Emerging evidence points towards the crucial impact of epigenetic post-translational modifications in cancer development with emphasis on the regulatory role of histone deacetylation in several key cellular processes, including metabolic pathways, regulation of stress response, senescence, proliferation, DNA repair, and apoptosis. The silent information regulator proteins (Sirtuins) are deacetylases of histone and non-histone proteins that have been recently implicated in the initiation as well as in the progression of GB. Herein, we provide a critical overview of the emerging functional role and mechanism of action of the seven Sirtuins (SIRT1-7) in GB and discuss their potential targeting options in clinical practice.
Radiation Effects on Fiber Bragg Gratings: Vulnerability and Hardening Studies

Fiber Bragg gratings (FBGs) are point optical fiber sensors that allow the monitoring of a diversity of environmental parameters, e.g., temperature or strain. Several research groups have studied radiation effects on the grating response, as they are implemented in harsh environments: high energy physics, space, and nuclear facilities. We report here the advances made to date in studies regarding the vulnerability and hardening of this sensor under radiation. First, we introduce its principle of operation. Second, the different grating inscription techniques are briefly illustrated as well as the differences among the various types. Then, we focus on the radiation effects induced on different FBGs. Radiation induces a shift in their Bragg wavelengths, which is a property serving to measure environmental parameters. This radiation-induced Bragg wavelength shift (RI-BWS) leads to a measurement error, whose amplitude and kinetics depend on many parameters: inscription conditions, fiber type, pre- or post-treatments, and irradiation conditions (nature, dose, dose rate, and temperature). Indeed, the radiation hardness of an FBG is not directly related to that of the fiber where it has been photo-inscribed by a laser. We review the influence of all these parameters and discuss how it is possible to manufacture FBGs with limited RI-BWS, opening the way to their implementation in radiation-rich environments.
Replica analysis of Bayesian data clustering

We use statistical mechanics to study model-based Bayesian data clustering. In this approach, each partition of the data into clusters is regarded as a microscopic system state, the negative data log-likelihood gives the energy of each state, and the data set realisation acts as disorder. Optimal clustering corresponds to the ground state of the system, and is hence obtained from the free energy via a low ‘temperature’ limit. We assume that for large sample sizes the free energy density is self-averaging, and we use the replica method to compute the asymptotic free energy density. The main order parameter in the resulting (replica symmetric) theory, the distribution of the data over the clusters, satisfies a self-consistent equation which can be solved by a population dynamics algorithm. From this order parameter one computes the average free energy, and all relevant macroscopic characteristics of the problem. The theory describes numerical experiments perfectly, and gives a significant improvement over the mean-field theory that was used to study this model in past.
Sterylglucosides in Fungi

Sterylglucosides (SGs) are sterol conjugates widely distributed in nature. Although their universal presence in all living organisms suggests the importance of this kind of glycolipids, they are yet poorly understood. The glycosylation of sterols confers a more hydrophilic character, modifying biophysical properties of cell membranes and altering immunogenicity of the cells. In fungi, SGs regulate different cell pathways to help overcome oxygen and pH challenges, as well as help to accomplish cell recycling and other membrane functions. At the same time, the level of these lipids is highly controlled, especially in wild-type fungi. In addition, modulating SGs metabolism is becoming a novel tool for vaccine and antifungal development. In the present review, we bring together multiple observations to emphasize the underestimated importance of SGs for fungal cell functions.
Epic Snowmen, Expert Takes, and Audience Orientation: How Journalistic Roles are Performed in Canadian Media

Exploring the differences between normative visions and actual practices (Mellado, 2020), through a content analysis of more than 3,700 news stories contextualized with surveys, and further unpacked by interviews with journalists, this article provides a comprehensive overview of journalistic role performance in Canada. Findings show few, yet distinct, differences between French and English media, and that Canadian journalists are often present in their stories; use high levels of infotainment; and demonstrate strong performance of both the civic and service roles compared to other countries, but perform far less of the watchdog role than journalists surveyed perceived.
Outflow Angles, Bulk Lorentz Factors, and Kinematics of Outflows from the Cores of Active Galactic Nuclei

Outflow angles and bulk Lorentz factors for 43 sources that have proper motions (compiled by Vermeulen and Cohen in 1994) are computed on the basis of Doppler factors and observed apparent motions in the plane of the sky. These estimates of outflow angles and bulk Lorentz factors are discussed along with their agreement with orientation unified models of active galactic nuclei. Intrinsic (i.e., rest frame) brightness temperatures computed by using the inverse Compton and equipartition Doppler factors are discussed along with their relevance to the "inverse Compton catastrophe. " Intrinsic luminosity densities and luminosities are presented, and the role of systematic errors is discussed. These studies are carried out using a sample of 100 compact radio sources that was compiled by Ghisellini and coworkers in 1993. Error estimates for previously computed inverse Compton Doppler factors and equipartition Doppler factors are presented for these sources, along with a few updates of these Doppler factor estimates.
The Relationship between Visceral Adiposity and Nonalcoholic Fatty Liver Disease Diagnosed by Controlled Attenuation Parameter in People with HIV: A Pilot Study

Background: Fat alterations are frequent in people with HIV (PWH) and predict worse cardiometabolic outcomes. Visceral adipose tissue (VAT) is associated with ectopic fat accumulation in the liver. We aimed to investigate nonalcoholic fatty liver disease (NAFLD) diagnosed by controlled attenuation parameter (CAP) as a potential marker of visceral adiposity in PWH. Methods: We conducted a prospective pilot study of HIV mono-infected patients undergoing metabolic characterization and paired CAP measured by transient elastography with dual-energy X-ray absorptiometry (DEXA) scan. NAFLD was defined as CAP ≥ 285 dB/m, in absence of alcohol abuse. Excess visceral adiposity was defined as VAT > 1.32 Kg. Pairwise correlation, area under the curve (AUC) and logistic regression analysis were employed to study the association between VAT and CAP. Results: Thirty patients were included, of whom 50% had NAFLD. CAP was correlated with VAT (r = 0.650, p < 0.001) measured by DEXA scan. After adjusting for duration of HIV infection, body mass index and waist circumference, CAP remained the only independent predictor of excess VAT (adjusted odds ratio 1.05, 95% confidence interval [CI] 1.01–1.10). The AUC analysis determined CAP had excellent performance to diagnose excess VAT (AUC 0.92, 95% CI 0.81–1.00), higher than BMI and waist circumference. The optimized CAP cut-off to diagnose excess VAT was 266 dB/m, with a sensitivity of 88.3% and a specificity of 84.6%. Conclusions: NAFLD diagnosed by CAP is associated with VAT in PWH independently of anthropometric measures of obesity. CAP may be a potential diagnostic marker of visceral adiposity in the practice of HIV medicine.
Comparison of functional and oncological outcomes between uterus-sparing radical cystectomy and standard radical cystectomy in females: A retrospective study

Purpose This study aimed to compare the functional and oncological outcomes of females who underwent uterus-sparing radical cystectomy (USRC) and standard radical cystectomy (SRC). Materials and Methods Between February 2009 and December 2020, 90 female patients who underwent radical cystectomy with urinary diversion were included in this study, comprising the USRC and SRC groups. Functional outcomes were assessed in 63 patients who only underwent radical cystectomy with neobladder formation. Questionnaire scores, clean intermittent catheterization (CIC) rate, and urinary continence rate were analyzed. Oncological outcomes were assessed in 86 patients, regardless of the urinary diversion type. Overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) were compared. Results CIC rate was significantly lower in the USRC group than in the SRC group (14.7% vs. 48.0%; p=0.005). The continence rate was significantly higher in the USRC group than in the SRC group (85.3% vs. 40.0%; p=0.001). There were no significant differences in OS (p=0.890), CSS (p=0.700), or RFS (p=0.270) between the two groups. In multivariate analysis, uterine preservation did not significantly increase the hazard ratio (HR) of OS (HR, 0.62; 95% CI, 0.18–2.11; p=0.450), CSS (HR, 0.99; 95% CI, 0.22–4.40; p=0.990), or RFS (HR, 0.46; 95% CI, 0.19–1.11; p=0.840). Conclusions USRC resulted in higher continence rates and lower CIC rates than SRC without negatively affecting oncological outcomes. Hence, with thorough deliberation, USRC should be considered for females undergoing radical cystectomy.
Interacting electrons with spin in a one-dimensional dirty wire connected to leads

We investigate a one-dimensional wire of interacting electrons connected to one-dimensional noninteracting leads in the absence and in the presence of a backscattering potential. The ballistic wire separates the charge and spin parts of an incident electron even in the noninteracting leads. The Fourier transform of nonlocal correlation functions is computed for $T\ensuremath{\gg}\ensuremath{\omega}$. In particular, this allows to study the proximity effect, related to the Andreev reflection. In addition, a new type of proximity effect emerges when the wire has normally a tendency towards Wigner crystal formation. The latter is suppressed by the leads below a space-dependent crossover temperature; it gets dominated everywhere by the ${2k}_{F}$ charge-density wave at $Tl{L}^{(3/2)(K\ensuremath{-}1)}$ for short-range interactions with parameter $Kl1/3$. The lowest-order renormalization equations of a weak backscattering potential are derived explicitly at finite temperature. A perturbative expression for the conductance in the presence of a potential with arbitrary spatial extension is given. It depends on the interactions, but is also affected by the noninteracting leads, especially for very repulsive interactions, $Kl1/3$. This leads to various regimes, depending on temperature and on $K$. For randomly distributed weak impurities, the conductance fluctuations, equal to that of $\mathcal{R}=g\ensuremath{-}{2e}^{2}/h$, are computed. They depend on the interaction parameters, and are different for electrons with or without spin. But the ratio $\mathrm{Var}(\mathcal{R})/{\mathcal{R}}^{2}$ stays always of the same order: it is equal to ${L}_{T}/L\ensuremath{\ll}1$ in the high-temperature limit, then saturates at $1/2$ in the low-temperature limit, indicating that the relative fluctuations of $\mathcal{R}$ are universal.
One-Pot Synthesis of Hyperbranched Polyurethane-Triazoles with Controlled Structural, Molecular Weight and Hydrodynamic Characteristics

We report a simple and convenient approach to the one-pot synthesis of hyperbranched polyurethane-triazoles with desirable properties. This method is based on in situ generation of an AB2 + A2 + B4 azide-acetylene monomer mixture of known composition, due to quantitative reactions of urethane formation between isophorone diisocyanate (IPDI), 1,3-diazidopropanol-2 (DAPOL) (in the first stage) and propargyl alcohol (in the second stage). The obtained monomer mixture can be involved in step-growth polymerization by azide-alkyne cycloaddition without additional purification (in the third stage). The properties of the resulting polymers should depend on the composition of the monomer mixture. Therefore, first the model revealing the correlation between the monomer composition and the ratio and reactivity of the IPDI and DAPOL active groups is developed and proven. In addition, the newly developed structural kinetic model considering the substitution effect at polyaddition of the complex mixture of monomers allows the prediction of the degree of branching of the target polymer. Based on our calculations, the hyperbranched polyurethane-triazoles were synthesized under found conditions. All products were characterized by 1H NMR, FTIR, SEC, DLS, DSC, TGA and viscometry methods. It was shown that the degree of branching, molecular weight, intrinsic viscosity, and hydrodynamic radius of the final hyperbranched polymers can be specified at the first stage of one-pot synthesis. The obtained hyperbranched polyurethane-triazoles showed a degree of branching from 0.21 to 0.44 (calculated DB-0.25 and 0.45, respectively).
Quantum Key Distribution Protocol with Private-Public Key

A quantum cryptographic protocol based in public key cryptography combinations and private key cryptography is presented. Unlike the BB84 protocol [1] and its many variants [2,3] two quantum channels are used. The present research does not make reconciliation mechanisms of information to derive the key. A three related system of key distribution are described.
Quantum qubit switch: entropy and entanglement

The quantum entanglement is considered as one of the most important notions of quantum computing. The entanglement is a feature of quantum systems and it is used as a basis for many quantum algorithms and protocols. In this paper we analyze the level of entanglement for the quantum switch, during its work. The level of entanglement during the correct operating may be compared with the situation when a noise is present in the analyzed system. The noise changes the level of quantum entanglement and we utilize this observation to evaluate if the switch works properly. We present the formulae describing the value of entanglement with use of the Concurrence measure and also the value of entropy. Both mentioned values may be utilized to detect the noise during the operating of quantum switch.
The spatial clustering of X-ray selected AGN and galaxies in the Chandra Deep Field South and North

We investigate the spatial clustering of X-ray selected sources in the two deepest X-ray fields to date, namely the 2 Ms Chandra Deep Field North (CDFN) and the 1 Ms Chandra Deep Field South (CDFS). The projected correlation function w(rp), measured on scales ∼0.2−10 h −1 Mpc for a sample of 240 sources with spectroscopic redshift in the CDFN and 124 sources in the CDFS at a median redshift of ¯ z ∼ 0.8 is used to constrain the amplitude and slope of the real space correlation function ξ(r) = (r/r0) −γ . The clustering signal is detected at high confidence (> 7σ) in both fields. The amplitude of the correlation is found to be significantly different in the two fields, the correlation length r0 being 8.6 ± 1.2 h −1 Mpc in the CDFS and 4.2 ± 0.4 h −1 Mpc in the CDFN, while the correlation slope γ is found to be flat in both fields: γ = 1.33 ± 0.11 in the CDFS and γ = 1.42 ± 0.07 in the CDFN (a flat Universe with Ωm = 0. 3a ndΩΛ = 0.7 is assumed; 1σ Poisson error estimates are considered). The correlation function also has been measured separately for sources classified as AGN or galaxies. In both fields AGN have a median redshift of ¯ ∼ 0. 9a nd am edian 0.5−10 keV luminosity of ¯ Lx ∼ 10 43 erg s −1 , i.e. they are generally in the Seyfert luminosity regime. As in the case of the total samples, we found a significant difference in the AGN clustering amplitude between the two fields, the best fit correlation parameters being r0 = 10.3 ± 1.7 h −1 Mpc, γ = 1.33 ± 0.14 in the CDFS, and r0 = 5.5 ± 0.6 h −1 Mpc, γ = 1.50 ± 0.12 in the CDFN. In the CDFN, where the statistics are sufficiently high, we were also able to measure the clustering of X-ray selected galaxies, finding r0 = 4.0 ± 0.7 h −1 Mpc and γ = 1.36 ± 0.15. Within each field no statistically significant difference is found between soft and hard X-ray selected sources or between type 1 and type 2 AGN. After having discussed and ruled out the possibility that the observed variance in the clustering amplitude is due to observational biases, we verified that the extra correlation signal in the CDFS is primarily due to the two prominent redshift spikes at z ∼ 0.7 reported by Gilli et al. (2003). The high (5−10 h −1 Mpc) correlation length measured for the X-ray selected AGN at z ∼ 1i n the twoChandra Ms fields is comparable to that of early type galaxies at the same redshift. This is consistent with the idea that, at z ∼ 1, AGN with Seyfert-like luminosities might be generally hosted by massive galaxies.
Focusing on the Role of Natural Products in Overcoming Cancer Drug Resistance: An Autophagy-Based Perspective

Autophagy is a critical cellular adaptive response in tumor formation. Nutritional deficiency and hypoxia exacerbate autophagic flux in established malignancies, promoting tumor cell proliferation, migration, metastasis, and resistance to therapeutic interventions. Pro-survival autophagy inhibition may be a promising treatment option for advanced cancer. Furthermore, excessive or persistent autophagy is cytotoxic, resulting in tumor cell death. Targeted autophagy activation has also shown significant promise in the fight against tumor drug resistance. Several research groups have examined the ability of natural products (NPs) such as alkaloids, terpenoids, polyphenols, and anthraquinones to serve as autophagy inhibitors or activators. The data support the capacity of NPs that promote lethal autophagy or inhibit pro-survival autophagy from being employed against tumor drug resistance. This paper discusses the potential applications of NPs that regulate autophagy in the fight against tumor drug resistance, some limitations of the current studies, and future research needs and priorities.
Polymorph Separation by Ordered Patterning

We herein address the problem of polymorph selection by introducing a general and straightforward concept based on their ordering. We demonstrated the concept by the ordered patterning of four compounds capable of forming different polymorphs when deposited on technologically relevant surfaces. Our approach exploits the fact that, when the growth of a crystalline material is confined within sufficiently small cavities, only one of the possible polymorphs is generated. We verify our method by utilizing several model compounds to fabricate micrometric “logic patterns” in which each of the printed pixels is easily identifiable as comprising only one polymorph and can be individually accessed for further operations.
Doppler and collisional frequency shifts in trapped-atom clocks

Collisions with background gas particles can shift the resonance frequencies of atoms in atomic clocks. The internal quantum states of atoms can also become entangled with their motional states due to the recoil imparted by a collision, which leads to a further shift of the clock frequency through the relativistic Doppler shift. It can be complicated to evaluate the Doppler and collisional frequency shifts for clock atoms in such entangled states, but estimates of these shifts are essential in order to improve the accuracy of optical atomic clocks. We present a formalism that describes collisions and relativistic Doppler shifts in a unified manner, and can therefore be used to accurately estimate collisional frequency shifts in trapped-atom clocks.
The Impact of Oral Health Behaviors, Health Belief Model, and Absolute Risk Aversion on the Willingness of Japanese University Students to Undergo Regular Dental Check-Ups: A Cross-Sectional Study

Oral health behaviors, risk aversion, and the health belief model are associated with health behaviors. However, there have been few studies that investigated the association between these factors and the willingness to undergo regular dental check-ups. The purpose of this cross-sectional study was to investigate the associations between the willingness of Japanese university students to undergo regular dental check-ups and oral health behaviors, the health belief model, and absolute risk aversion. An analysis was conducted with the cooperation of questionnaire respondents (n = 748) who underwent dental check-ups at Okayama University. The students answered questionnaires on oral health behaviors, the health belief model, absolute risk aversion, and willingness to undergo regular dental check-ups. The logistic regression analysis showed significant positive associations (p < 0.05) between oral health behaviors (use of the inter-dental brush and the dental floss) and the health belief model with the willingness to undergo regular dental check-ups. However, there was no significant association with absolute risk aversion (p > 0.05). These results suggest that willingness to undergo regular dental check-ups was associated with oral health behaviors and the health belief model, but not with absolute risk aversion.