Miracle-dz/UniFAR-FTUs huggingface dataset:
Center for Policy Research Working Paper No. 54

We estimate the incentive effects of income taxation in a life-cycle model of consumption and labor supply that relaxes the standard assumption of strong separability within periods. Our model permits identification of both within-period preference parameters and lifecycle preference parameters such as the inter-temporal substitution elasticity. Results indicate that consumption and hours worked are direct complements in utility, and both increase with an increase in the after-tax share and with a compensated increase in the net wage. The compensated net wage elasticity is about 0.3, nearly double the standard estimates for men in the United States that ignore within-period non-separability between consumption and hours and rely on linear preferences. Given our estimated inter-temporal elasticity of substitution of about – 0.96, the Frisch specific substitution elasticities of consumption and labor supply with respect to the after-tax wage are about 0.1 and 0.5, indicating significant inter-temporal smoothing of utility. Depending on consumption measure, static estimates of the marginal welfare cost of revenue-neutral taxation are 6–20 percent, which is about half the estimated welfare cost when additivity between consumption and leisure is incorrectly imposed.
Electric field characteristics of rotating permanent magnet stimulation

Neurostimulation devices that use rotating permanent magnets are being explored for their potential therapeutic benefits in patients with psychiatric and neurological disorders. This study aims to characterize the electric field (E-field) for ten configurations of rotating magnets using finite element analysis and phantom measurements. Various configurations were modeled, including single or multiple magnets, bipolar or multipolar magnets, rotated at 10, 13.3, and 400 Hz. E-field strengths were also measured using a hollow sphere filled with a 0.9% sodium chloride solution and with a dipole probe. The E-field spatial distribution is determined by the magnets' dimensions, number of poles, direction of the magnetization, and axis of rotation, while the E-field strength is determined by the magnets' rotational frequency and magnetic field strength. The induced E-field strength on the surface of the head ranged between 0.0092 and 0.59 V/m. At the range of rotational frequencies applied, the induced E-field strengths were approximately an order or two of magnitude lower than those delivered by conventional transcranial magnetic stimulation. The impact of rotational frequency on E-field strength represents a previously unrecognized confound in clinical trials that seek to personalize stimulation frequency to individual neural oscillations and may represent a mechanism to explain some clinical trial results.
Seasonality of Respiratory, Enteric and Urinary Viruses Revealed by Wastewater Genomic Surveillance

Wastewater surveillance can reveal population-level infectious disease burden and emergent public health threats can be reliably assessed through wastewater surveillance. While molecular methods for wastewater monitoring of microorganisms have traditionally relied on PCR-based approaches, next-generation sequencing can provide deeper insights via genomic analyses of multiple diverse pathogens. We conducted a year-long sequencing surveillance of 1,408 composite wastewater samples collected from 12 neighborhood-level access points in the Greater Tempe area, Arizona, USA, and show that variation in wastewater viromes is driven by seasonal time and location. Wastewater virome temporal dynamics were influenced in a cyclical manner, with the most dissimilarity between samples 23 weeks apart (i.e., winter vs summer, spring vs fall). We identified diverse urinary and enteric viruses including polyomaviruses, astroviruses and noroviruses, and showed that their genotypes/subtypes shifted across season. We show that while wastewater data of certain respiratory viruses like SARS-CoV-2 strongly correlate with clinical case rates, laboratory-reported case incidences were discordant with surges of high viral load in wastewater for other viruses like human coronavirus 229E. These results demonstrate the utility of wastewater sequencing for informing decision making in public health.
Diagnostic Delay in HPV-Related Oropharyngeal Squamous Cell Carcinoma

Introduction Human papillomavirus-related (HPV + ) oropharyngeal squamous cell carcinoma (OPSCC) is increasing in incidence and presents diagnostic challenges given its unique clinical presentation. Objective The purpose of the present study is to characterize the impact of the unique clinical presentation of HPV-related OPSCC on delays in diagnosis. Methods Retrospective review of presenting symptoms and clinical characteristics of 284 patients with OPSCC treated from 2002–2014. Delay in diagnosis was defined as the presence of any of the following: multiple non-diagnostic fine needle aspirate (FNA) biopsies; two or more courses of antibiotic therapy; surgery with incorrect preoperative diagnosis; evaluation by an otolaryngologist without further workup; or surgery without definitive postoperative diagnosis. Results p16+ tumors demonstrated a distinct clinical presentation that more commonly involved a neck mass (85.1% versus 57.3% of p16-; p < 0.001) and less frequently included odynophagia (24.6% versus 51.7% of p16-; p < 0.001). Patients who experienced diagnostic delay were more likely to have p16+ tumors (77.7% delayed versus 62.8% not delayed; p = 0.006). p16+ primary tumors were more likely to be undetectable by physical examination of the head and neck including flexible laryngoscopy (19.0% versus 6.7% of p16-; p = 0.007) and more frequently associated with nondiagnostic FNA biopsies of a cervical nodal mass (11.8% versus 3.4% of p16-, p = 0.03). Conclusions Compared with non-HPV related OPSCC, the unique clinical presentation and characteristics of HPV+ OPSCC are associated with an increased incidence of diagnostic delay. Targeted education of appropriate care providers may improve time to diagnosis and treatment.
Gut-Liver-Brain Axis and Alcohol Use Disorder: Treatment Potential of Fecal Microbiota Transplantation

PURPOSE Chronic alcohol use is a major cause of liver damage and death. In the United States, multiple factors have led to low utilization of pharmacotherapy for alcohol use disorder (AUD), including lack of provider knowledge and comfort in prescribing medications for AUD. Alcohol consumption has direct effects on the gut microbiota, altering the diversity of bacteria and leading to bacterial overgrowth. Growing evidence suggests that alcohol’s effects on the gut microbiome may contribute to increased alcohol consumption and progression of alcohol-associated liver disease (ALD). This article reviews human and preclinical studies investigating the role of fecal microbiota transplantation (FMT) in ameliorating alcohol-associated alterations to the liver, gut, and brain resulting in altered behavior; it also discusses the therapeutic potential of FMT. SEARCH METHODS For this narrative review, a literature search was conducted in September 2022 of PubMed, Web of Science Core Collection, and Google Scholar to identify studies published between January 2012 and September 2022. Search terms used included “fecal microbiota transplantation” and “alcohol. ” SEARCH RESULTS Most results of the literature search were review articles or articles on nonalcoholic fatty liver disease; these were excluded. Of the remaining empirical manuscripts, very few described clinical or preclinical studies that were directly investigating the effects of FMT on alcohol drinking or related behaviors. Ultimately, 16 studies were included in the review. DISCUSSION AND CONCLUSIONS The literature search identified only a few studies that were directly investigating the effect of FMT on ALD or alcohol drinking and related behaviors. Largely proof-of-concept studies, these findings demonstrate that alcohol can alter the gut microbiome and that the microbiome can be transferred between humans and rodents to alter affective behaviors frequently associated with increased alcohol use. Other studies have shown promise of FMT or other probiotic supplementation in alleviating some of the symptoms associated with ALD and drinking. These results show that the implementation of FMT as a therapeutic approach is still in the investigatory stages.
Performance of ionic liquid functionalized metal organic frameworks in the adsorption process of phenol derivatives

The growth of industrial activities has produced a significant increase in the release of toxic organic pollutants (OPs) to the environment from industrial wastewater. On this premise, this study reports the use of metal organic frameworks (MOFs) impregnated with various ionic liquids (ILs) in the adsorption of phenol derivatives, i.e., 2,6-dimethylphenol and 4,4′-dihydroxybiphenyl. MOFs were prepared starting from 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) with divalent (Co, Ni, Cu) and trivalent (Ce) metal salts in mild hydrothermal conditions using water as a green solvent. Imidazolium base ionic liquids, namely 1-butyl-3-methylimidazolium trifluoromethanesulfonate, 1-butyl-3-methylimidazolium nitrate, 1-butyl-3-methylimidazolium chloride, and 1-hexyl-3-methyl-imidazolium chloride, were used to modify MOFs, leading to composite materials (IL@MOF), which show the structural characteristics of MOFs, and complement the advantages of ILs. SEM, EDX images, and TG data indicate that the IL is just attached on the surface of the adsorbent material, with no changes in crystal size or morphology, but with slightly altered thermal stabilities of IL@MOF composites compared to the original ILs and MOFs, pointing to some interionic interaction between IL and MOF. This research consists of equilibrium experiments, studying the effect of the initial concentration of OPs on the adsorption efficiency of the as-prepared MOFs and IL@MOF, in order to determine the influence of the nature of the adsorbent on its developed adsorption capacity and to investigate the performance of both ILs and MOFs. To determine the maximum adsorption capacity, several empirical isotherms were used: Langmuir, Freundlich, Redlich–Peterson, and Dubinin–Radushkevich. The characteristic parameters for each isotherm and the correlation coefficient (R2) were identified. The IL modification of MOFs increased the adsorption capacity of IL@MOF for the removal of phenol derivatives from aqueous solution. The adsorption capacity function of the MOF structure follows the trend CeHEDP > CoHEDP > NiHEDP > CuHEDP. The best performance was achieved by adsorbent materials based on Ce.
A Review of Genes Involved in Wound Healing

Background Gene therapy holds immense potential in the field of wound healing. However, we still do not recognize this procedure well enough to give oversight effectively to improve healing processes. A wide range of information has been achieved from the database for gene expression profiling by clinical trials, So we performed this study to gain a better understanding of the mechanisms behind wound healing and how it could be utilized to develop new therapies and treatments. Methods In this study, we have been focusing on wound-healing genes, conducting a thorough review to explore the various genes and pathways involved in this process. For this purpose, a total of 320 articles were collected. All experimental studies, systematic or narrative reviews, studies and clinical trials included in this paper were searched on PubMed, Medline, Embase, Science Direct, and Scopus databases in English using the following terms: Wound Healing, wound regeneration, Gene Transfer, and Gene Therapy were used to search the mentioned databases. Unfortunately, we didn’t find a large sample cohort study on this topic. A total amount of 330 articles were collected based on the guidelines of the PRISMA method. Both inclusion and exclusion criteria were settled. Results During the last decade, different models of gene delivery have been introduced, which include viral transfection and Non-viral techniques. In this regard, TIMP-2 protein and VEGF mutants such as VEGF165, CARP, and HIF-1 are the genes that accelerate the rate of tissue repair. Conclusion The process of wound healing is mainly related to the change of expression of genes that have a role in the parts of inflammation and repair. In our study, some of the most suitable genes involved in the wound-healing process are mentioned.
The Recent Transmission and Associated Risk Factor of Mycobacterium tuberculosis in Golmud City, China

Background Tuberculosis (TB) remains a severe public health problem globally, and it is essential to comprehend the transmission pattern to control tuberculosis. Herein, we evaluated the drug-resistant characteristics, recent transmission, and associated risk factors of TB in Golmud, Qinghai, China. Methods In this study, we performed a population-based study of patients diagnosed with TB in Golmud from 2013 to 2018. Drug-susceptibility testing and whole-genome sequencing were performed on 133 Mycobacterium tuberculosis strains. The genomic clustering rate was calculated to evaluate the level of recent transmission. Risk factors were identified by logistic regression analysis. Results Our results showed that 46.97% (62/132) of strains were phylogenetically clustered and formed into 23 transmission clusters, suggesting a high recent transmission of TB in the area. 12.78% (17/133) strains were multidrug-resistant/rifampicin tuberculosis (MDR/RR-TB), with a high drug-resistant burden. Based on drug resistance gene analysis, we found 23 strains belonging to genotype MDR/RR-TB, where some strains may have borderline mutations. Among these strains, 65.2% (15/23) were found within putative transmission clusters. Additionally, risk factor analysis showed that recent transmission of TB happened more in patients with Tibetan nationality or older age. Conclusion Overall our study indicates that the recent transmissions of MTB strains, especially genotypic MDR/RR strains, drive the tuberculosis epidemic in Golmud, which could contribute to developing effective TB prevention and control strategies.
USE OF LANDSAT MULTISPECTRAL SCANNER IMAGERY AND GEOGRAPHIC INFORMATION SYSTEMS TO MAP VEGETATION IN THE NORTH CASCADES GRIZZLY BEAR ECOSYSTEM

Landsat multispectral scanner (MSS) imagery and a ground-based vegetative inventory were used to develop a map of vegetation for the North Cascades Grizzly Bear Ecosystem (NCGBE). An assessment of the interpreted data showed a 95% accuracy level for the general vegetation types and 92% for detailed vegetation types. Additional data layers were developed in a geographic information system (GIS) to evaluate the availability and distribution of vegetation types on a seasonal basis, assess the impacts of human activities on the habitat, assess ungulate food sources, and estimate the abundance of bear foods in various vegetation types. These technologies proved useful in evaluating the suitability of the ecosystem to support grizzly bears (Ursus arctos horribilis).
Rheumatoid Arthritis-Like Symptoms After Taking Relugolix, With Primary Exacerbation After Discontinuation of the Drug

We report a case of a 43-year-old woman who developed rheumatoid arthritis-like symptoms after taking relugolix, presenting a diagnostic challenge in distinguishing between initial symptoms of rheumatoid arthritis and the side effects of the drug. The patient, scheduled for a total laparoscopic hysterectomy owing to uterine fibroids, started taking relugolix five and a half months prior to surgery. Three months later, she developed rheumatoid arthritis-like stiffness in both hands, especially in the mornings. Despite consultations with the rheumatology department and negative blood and imaging findings for rheumatoid arthritis, her joint symptoms worsened after surgery. Treatment for early-stage rheumatoid arthritis was initiated, and the symptoms peaked after six months. Similar to estrogen-lowering aromatase inhibitors that are known to cause joint symptoms, relugolix might also induce these effects.
Genomic heterogeneity of multiple synchronous lung cancers in Chinese population

Abstract Introduction It is clinically challenging to infer the phylogenetic relationship between different tumor lesions of patients with multiple synchronous lung cancers (MSLC), whether these lesions are the result of independently evolved tumor or intrapulmonary metastases. Methods We used the Illumina X10 platform to sequence 128 stage I lung cancer samples collected from 64 patients with MSLC. All samples were analyzed for mutation spectra and phylogenetic inference. Results We detected genetic aberrations within genes previously reported to be recurrently altered in lung adenocarcinoma including, EGFR, ERBB2, TP53, BRAF, and KRAS. Other putative driver mutations identified were enriched in RTK‐RAS signaling, TP53 signaling, and cell cycle. Also, we found some interesting cases, two cases that carried EGFR L858R and T790M co‐mutation in one tumor and another tumor with only EGFR 19del, and 1 case with two KRAS hotspots in the same tumor. Due to the short follow‐up time and early stage, further investigation is needed to determine whether this unique mutation profile will affect their progression‐free survival (PFS) and overall survival (OS). Regarding genetic evolution analysis among 64 tumor samples, 50 of them display distinct mutational profiles, suggesting these are independently evolved tumors, which is consistent with histopathological assessment. On the other hand, six patients were identified to be intrapulmonary metastasis as the mutations harbored in different lesions are clonally related. Conclusion In summary, unlike intrapulmonary metastases, patients with MSLC harbor distinct genomic profiles in different tumor lesions, and we could distinguish MSLC from intrapulmonary metastases via clonality estimation.
Emergence and Transition in London’s Climate Change Adaptation Pathways

Climate change adaptation coevolves with urban development trajectories presenting decision-makers with a choice of positioning adaptation to protect or revise development. This relational view of adaptation in the context of large cities opens questions on the ways in which city and other actors interact. This interaction may be as or more important than resource and information access for shaping the adaptive capacity and direction of such assemblages. Transitions between modes of adaptation are little understood and will likely combine autonomous and deliberate change both incremental and transformative. Using London as a case study, the paper identifies the contemporary adaptation regime to extreme events and its lines of movement. Interviews and a scenario workshop with resilience planners and emergency managers show the orientation of London’s adaptation is firmly positioned in a mode of resilience, protecting development through flexibility. Maintaining resilience to extremes under conditions of economic austerity is seen to result in the shifting of risk management burdens onto those at risk. Self-reliance is emerging as a mechanism for deepening the resilience mode of adaptation. At the same time, when considering potential risks for extreme events in 2035, most planners express a desire for more transformative adaptation that can tackle root causes in social conditions. A gap is revealed between the professional judgment of risk and resilience planning needs and likely trajectories constrained by national administrations and policy.
Comparison of Cloud Coverage over Northwestern China with Respect to Typical Regions

Using CERES SSF Aqua MODIS Edition 1B data from July 2002 to June 2004 from Clouds and the Earth’s Radiant Energy System (CERES) of NASA’s EOS,the authors analyzed the spatial distribution, seasonal and annual variability of the coverage of total cloud, lower layer cloud and upper layer cloud over northwestern China with respect to four typical regions with different climatic and environmental conditions. The results show that the high measurements of lower layer cloud coverage not only occurred over mountains but also over non-mountainous regions,but the high measurements of upper layer cloud coverage only occurred over mountains. Generally, the cloud coverage measurements varied significantly over the four regions. The largest difference of yearly means of upper layer cloud coverage was between the Qilian Mountains and the Taklimakan Desert which was 16.4%, and those of total cloud coverage and lower layer cloud coverage were both between the Asia monsoon influence region and the Taklimakan Desert which were 27.6% and 19.5%,respectively. The highest measurements of cloud coverage parameters over the monsoon influence region and Qilian Mountains generally occurred in summer while theose over the Tianshan Mountains and the Taklimakan Desert occurred in spring. The measurements of the three cloud coverage parameters were relatively high from March to September and their lowest measurements occurred from October to December.
The impact of standard and hard‐coded parameters on the hydrologic fluxes in the Noah‐MP land surface model

Land surface models incorporate a large number of process descriptions, containing a multitude of parameters. These parameters are typically read from tabulated input files. Some of these parameters might be fixed numbers in the computer code though, which hinder model agility during calibration. Here we identified 139 hard‐coded parameters in the model code of the Noah land surface model with multiple process options (Noah‐MP). We performed a Sobol' global sensitivity analysis of Noah‐MP for a specific set of process options, which includes 42 out of the 71 standard parameters and 75 out of the 139 hard‐coded parameters. The sensitivities of the hydrologic output fluxes latent heat and total runoff as well as their component fluxes were evaluated at 12 catchments within the United States with very different hydrometeorological regimes. Noah‐MP's hydrologic output fluxes are sensitive to two thirds of its applicable standard parameters (i.e., Sobol' indexes above 1%). The most sensitive parameter is, however, a hard‐coded value in the formulation of soil surface resistance for direct evaporation, which proved to be oversensitive in other land surface models as well. Surface runoff is sensitive to almost all hard‐coded parameters of the snow processes and the meteorological inputs. These parameter sensitivities diminish in total runoff. Assessing these parameters in model calibration would require detailed snow observations or the calculation of hydrologic signatures of the runoff data. Latent heat and total runoff exhibit very similar sensitivities because of their tight coupling via the water balance. A calibration of Noah‐MP against either of these fluxes should therefore give comparable results. Moreover, these fluxes are sensitive to both plant and soil parameters. Calibrating, for example, only soil parameters hence limit the ability to derive realistic model parameters. It is thus recommended to include the most sensitive hard‐coded model parameters that were exposed in this study when calibrating Noah‐MP.