Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigation of Sperm and Seminal Plasma Candidate MicroRNAs of Bulls with Differing Fertility and In Silico Prediction of miRNA-mRNA Interaction Network of Reproductive Function

Simple Summary The objective of this study was to identify differentially expressed (DE) sperm and seminal plasma microRNAs (miRNAs) in high- and low-fertile Holstein bulls (four bulls per group), integrate miRNAs to their target genes, and categorize target genes based on predicted biological processes. Out of 84 bovine-specific, prioritized miRNAs analyzed by RT-PCR, 30 were differentially expressed in high-fertile sperm and seminal plasma compared to low-fertile sperm and seminal plasma, respectively (p ≤ 0.05, fold regulation ≥5 magnitudes). Interestingly, expression levels of DE-miRNAs in sperm and seminal plasma followed a similar pattern. Highly scored integrated genes of DE-miRNAs predicted various biological and molecular functions, cellular process, and pathways. Further in silico analysis revealed categorized genes may have a plausible association with pathways regulating sperm structure and function, fertilization, and embryo and placental development. In conclusion, highly DE-miRNAs in bovine sperm and seminal plasma could be used as a tool for predicting reproductive functions. Since the identified miRNA-mRNA interactions were mostly based on predictions from public databases, the causal regulations of miRNA-mRNA and the underlying mechanisms require further functional characterization in future studies. Abstract Recent advances in high-throughput in silico techniques portray experimental data as exemplified biological networks and help us understand the role of individual proteins, interactions, and their biological functions. The objective of this study was to identify differentially expressed (DE) sperm and seminal plasma microRNAs (miRNAs) in high- and low-fertile Holstein bulls (four bulls per group), integrate miRNAs to their target genes, and categorize the target genes based on biological process predictions. Out of 84 bovine-specific, prioritized miRNAs analyzed by RT-PCR, 30 were differentially expressed in high-fertile sperm and seminal plasma compared to low-fertile sperm and seminal plasma, respectively (p ≤ 0.05, fold regulation ≥ 5 magnitudes). The expression levels of DE-miRNAs in sperm and seminal plasma followed a similar pattern. Highly scored integrated genes of DE-miRNAs predicted various biological and molecular functions, cellular process, and pathways. Further, analysis of the categorized genes showed association with pathways regulating sperm structure and function, fertilization, and embryo and placental development. In conclusion, highly DE-miRNAs in bovine sperm and seminal plasma could be used as a tool for predicting reproductive functions. Since the identified miRNA-mRNA interactions were mostly based on predictions from public databases, the causal regulations of miRNA-mRNA and the underlying mechanisms require further functional characterization in future studies.
A 3D Frictionless Contact Domain Method for Large Deformation Problems

This work describes a three-dimensional contact domain method for large deformation frictionless contact problems. Theoretical basis and numerical aspects of this specific contact method are given in [Oliver, Hartmann, Cante, Weyler and Hernández (2009)] and [Hartmann, Oliver, Weyler, Cante and Hernández (2009)] for two-dimensional, large deformation frictional contact problems. In this method, in contrast to many other contact formulations, the necessary contact constraints are formulated on a so-called contact domain, which can be interpreted as a fictive intermediate region connecting the potential contact surfaces of the deformable bodies. This contact domain has the same dimension as the contacting bodies. It will be endowed with a displacement field, interpolated from the displacements at the contact surfaces and will be subdivided into a non-overlapping set of contact patches, where the contact constraints will be applied. For the enforcement of these contact constraints a stabilized Lagrange multiplier method is used, which allows the condensation of the introduced Lagrange multipliers, leading to a purely displacement driven problem.
Speakers' emotional facial expressions modulate subsequent multi-modal language processing: ERP evidence

ABSTRACT We investigated the brain responses associated with the integration of speaker facial emotion into situations in which the speaker verbally describes an emotional event. In two EEG experiments, young adult participants were primed with a happy or sad speaker face. The target consisted of an emotionally positive or negative IAPS photo accompanied by a spoken emotional sentence describing that photo. The speaker's face either matched or mismatched the event-sentence valence. ERPs elicited by the adverb conveying sentence valence showed significantly larger negative mean amplitudes in the EPN and descriptively in the N400 time windows for positive speaker faces - negative event-sentences (vs. negatively matching prime-target trials). Our results suggest that young adults might allocate more processing resources to attend to and process negative (vs. positive) emotional situations when being primed with a positive (vs. negative) speaker face but not vice versa. Post-hoc analysis indicated that this interaction was driven by female participants. We extend previous eye-tracking findings with insights into the timing of the functional brain correlates implicated in integrating the valence of a speaker face into a multi-modal emotional situation.
Anomalous dynamical scaling from nematic and U(1)-gauge field fluctuations in two dimensional metals

We analyze the scaling theory of two-dimensional metallic electron systems in the presence of critical bosonic fluctuations with small wave vectors, which are either due to a U(1) gauge field, or generated by an Ising nematic quantum critical point. The one-loop dynamical exponent z=3 of these critical systems was shown previously to be robust up to three-loop order. We show that the cancellations preventing anomalous contributions to z at three-loop order have special reasons, such that anomalous dynamical scaling emerges at four-loop order.
Workplace deviance and its impact on Organizational
Citizenship Behavior of Subordinates

The connection between the perceptions of Workplace deviance among subordinates and its relation to their Organization Citizenship Behavior has been discussed in this research. As expected, relation between procedural justice and hypothesized causal descriptions of Organizational citizenship duties and the association among workplace deviance and discretionary behavior of subordinates, which was more pronounced in those who described it "OCB" as extended behavior. The study's consequences for theoretical approaches are examined, along with its shortcomings and potential paths for future investigation
The Indirect Effects of Episodic-Thematic Framing on Information Sharing About the Economic Threat of Artificial Intelligence

ABSTRACT Developing artificial intelligence (AI) equitably necessitates understanding how nonexperts conceptualize and share news about technoscientific risk. We examine a model predicting AI information sharing online from an interaction of framing strategies, through psychological proximity to the impacts of AI and perceived AI risk. A panel of N = 412 participants were exposed to either a control message; or one of four manipulated messages related to AI risks. Contrary to expectations, thematically framed explicit risk news primed psychological proximity compared to both a control message and episodic frame condition. Meanwhile, episodic explicit risk frames did not prime psychological proximity over a control message. These results contest the notion that episodic frames should be associated with psychological proximity to a risk over more general framing strategies. Our results support prior research suggesting that where risk-news primes psychological proximity, the decrease in distance is in-turn associated with greater risk perception and increased likelihood of news sharing online.
False discovery rate control and the dependence structure of test statistics

The False Discovery Rate (FDR) was proposed in Benjamini and Hochberg (1995) as a powerful approach to the multiplicity problem that does not require strong control of the familywise error rate (FWER). The original approach was developed for independent test statistics and was later extended to dependent statistics in Benjamini and Yekutieli (2001) and Yekutieli (2008). In this paper we extend the existing results by showing that the assumptions on the dependence structure among classes of univariate statistics, that lead to the FDR control, may be represented by specific copulas.
Quando não é só uma gripe: relato de caso de uma miosite viral

Introdução: As infeções das vias aéreas superiores (IVAS) em crianças são dos motivos mais comuns de consulta aguda nos cuidados de saúde primários e habitualmente têm bom prognóstico. No entanto, em certos quadros clínicos, as complicações ou doenças menos comuns, como a miosite, devem ser consideradas. Descrição do caso: Uma criança de oito anos de idade, previamente saudável, foi observada pela primeira vez no centro de saúde em novembro de 2019 por tosse e febre com dois dias de evolução, sem alterações de relevo no exame objetivo – foi assumida uma IVAS e prescrito tratamento com antipirético e reforço da hidratação oral. O doente volta três dias depois à unidade com manutenção do quadro clínico, marcha anormal e dor na região posterior da perna, na região dos músculos gastrocnemius bilateralmente. Ao exame objetivo e neurológico, além da alteração da marcha, não apresentava outros achados. Pela evolução suspeita do quadro foi referenciado para o serviço de urgência pediátrico hospitalar para avaliação. Não foram encontradas outras alterações ao exame objetivo. Foi submetido a estudo analítico, que revelou uma creatina cinase (CK) de 7110U/L, mioglobina de 1935ng/ml e aspartato aminotransferase (AST) de 191U/L, sem alteração de função renal. Perante resultados sugestivos de miosite foi decidido internamento para fluidoterapia intravenosa. Em regime de internamento foi realizado aspirado nasofaríngeo para cultura e virologia, que testou positivo para vírus Influenza B; foi, assim, assumido o diagnóstico de miosite vírica por Influenza B. O doente recebeu tratamento com oseltamivir durante quatro dias em regime de internamento, com boa resposta. Teve alta hospitalar após estes quatro dias, assintomático e com indicação para repouso e reforço da hidratação oral. Comentário: Devemos estar atentos a sintomas menos comuns em casos de presumíveis de IVAS e aumentar a acessibilidade dos cuidados de saúde primários para reavaliações de certos casos.
Dichotomization of quantitative variables in poverty analysis

It has been proposed four schemes of dichotomization for the four household level quantitative variables – area of land holding, geographic accessibility to the nearest market centre, number of children under 15 and number of literate members of working-age – with justification in the selection of threshold value for each variable to dichotomize into disadvantaged and advantaged group of households using the Nepal Living Standard Survey 2010/11 data with 5988 households and 28,670 of their household members. Association of each dichotomized variable with household level poverty status (poor/non-poor) was found highly significant. Finally, the proposed schemes of dichotomization have tested empirically for their ability to differentiate the poor people into two categories - ‘more vulnerable’ and ‘less vulnerable’ - by fist estimating the three measures of poverty – head count index, poverty gap index and squared poverty gap index - of each group of population and comparing the estimated measures between the disadvantaged and advantaged group of populations. Statistical analysis has been performed by using IBM SPSS version 20. To a large extent the proposed schemes of dichotomization have found to differentiate the poor people into two groups; for example, the head count index of the disadvantaged group of the number of children under 15 is 3.1 times higher than that of the advantaged group. The results of this paper are expected to be useful to the policy makers and development planners of Nepal for focusing their poverty reduction program towards the more vulnerable group of population as well as academician. BIBECHANA 19 (2022) 142-149
The search for a causal link between CMEs and large flares

It would be remarkable if the two most dramatic and energetic solar transients, the large CME (coronal mass ejection) and large flare, were truly independent. The search for a causal connection is on-going, but so far has not been established. A separate, but longstanding problem is the source of the energy released in a large flare, as in many, if not all, cases this does not appear to come from the active region magnetic field. We discuss here a model whereby non-thermal energetic particles provide both the link between CMEs and flares, and a significant part of the flare energy. From an energetics viewpoint ions dominate, and to avoid gamma ray production which would be observable by current instrumentation, the ions should be below around 1 MeV/nucleon. Plausible ways of generating an adequate ion population within the CME structure, which for large events is over 90 degrees in projection, are indicated. Evidence for the release into space of some of this population is presented. The non-thermal electrons responsible for the hard X-ray and microwave signatures are generated near the chromospheric flare site, together with the highly relativistic ions which often accompany large flares.
Insider Filing Violations and Illegal Information Delay

Abstract We document that a significant number of insiders violate the Securities and Exchange Commission (SEC) reporting requirements by filing open market transactions after the legally required deadline. Prior to the Sarbanes–Oxley Act (SOX), 29% of transactions fell outside the required reporting window. Following SOX, 8% are delinquent. Violations cluster in periods of high information asymmetry, incentivizing insiders to keep trades private and earn abnormal returns. Collectively, these findings suggest that a subgroup of insiders personally benefit from violating SEC disclosure requirements. Evidence also suggests that blockholders provide governance for violations. Guilty insiders experience a reduction in board seats and an increased likelihood of turnover.
The secondary flow in a short aspect ratio circular lid driven cavity at small but finite Reynolds number

Regular perturbation solutions are obtained for the Stokes flow field, the first order effects of inertia on the flow field, and the primary and secondary pressure fields in the circular lid driven cavity. The physical mechanism that causes vortex breakdown exists at small Reynolds number; it is a stagnation of the secondary flow by an adverse pressure gradient. The discontinuity between the rotating lid and the stationary sidewall has negligible influence on the flow field provided that the inertial forcing of the secondary flow is not localized near the boundary discontinuity, and the Reynolds number is small.
Direct Charge Control Method for Inverters in Discontinuous Conduction Mode

The discontinuous conduction mode (DCM) of the inductor current is an effective way to achieve high efficiency and high power density of inverters because it has the advantages of zero-current switching and small inductance of the filter inductor. Although the DCM can operate at a fixed switching frequency, there has been no linear model for realizing high-performance digital control. This paper provides a solution for this problem. Firstly, a linear first-order charge quantity model (CQM) for a DCM inverter with a fixed switching frequency is established, which uses charge quantities output by the inverter bridge as a control variable. Secondly, a direct charge control (DCC) method is proposed, and the design process is significantly simplified. Finally, the performance of the proposed control method is verified by the experiments using a 1 kW prototype, and a high-quality output voltage waveform with a peak efficiency of above 98% was achieved. The proposed method outperforms existing works because the CQM is a first-order linear model that realizes the high-performance digital control and significantly simplifies the design of controller.
Multiscale Kernel-Based Residual CNN for Estimation of Inter-Turn Short Circuit Fault in PMSM

The diagnosis of an inter-turn short circuit (ITSC) fault at its early stage is very important in permanent magnet synchronous motors as these faults can lead to disastrous results. In this paper, a multiscale kernel-based residual convolutional neural network (CNN) algorithm is proposed for the diagnosis of ITSC faults. The contributions are majorly located on two sides. Firstly, a residual learning connection is embedded into a dilated CNN to overcome the defects of the conventional convolution and the degradation problem of a deep network. Secondly, a multiscale kernel algorithm is added to a residual dilated CNN architecture to extract high-dimension features from the collected current signals under complex operating conditions and electromagnetic interference. A motor fault experiment with both constant operating conditions and dynamics was conducted by setting the fault severity of the ITSC fault to 17 levels. Comparison with five other algorithms demonstrated the effectiveness of the proposed algorithm.
An effective method of calculating the non-Markovianity $\mathcal{N}$ for single channel open systems

We propose an effective method which can simplify the optimization of the increase of the trace distance over all pairs of initial states in calculating the non-Markovianity N for single-channel open systems. For the amplitude-damping channel, we can unify the results of Breuer et al. [Phys. Rev. Lett. 103, 210401 (2009)] in the large-detuning case and the results of Xu et al. [Phys. Rev. A 81, 044105 (2010)] in the resonant case; furthermore, for the general off-resonant cases, we can obtain a very tight lower bound of N. As another application of our method, we also discuss Nfor the non-Markovian depolarizing channel.
Consumption Patterns of Processed Foods in Singapore—A Cross-Sectional Study

The consumption of processed foods is increasingly widespread and could have an impact on diet quality and health. Understanding the factors influencing people’s eating habits is useful for assessing such impact. There are limited data on the consumption patterns of processed foods and associated factors influencing the dietary patterns in Singapore. This cross-sectional study based on a food frequency questionnaire aimed to examine how the consumption of processed foods among 2079 Singapore residents aged 18 to 89 years varies with sociodemographic factors. The analysis of the consumption by processed food groups showed that the studied factors, i.e., age, gender, ethnicity, housing and health status, all contributed to differences in processed food consumption to varying extents, with ethnicity being the key factor driving the variation. Such differences were also confirmed to a limited degree by determining another measure of consumption, i.e., a processed food variety score. The findings in this study could inform further work in relation to dietary risks.
Genome-Wide Identification of Laminin Family Related to Follicular Pseudoplacenta Development in Black Rockfish (Sebastes schlegelii)

As major elements of the basement membrane, laminins play a significant role in angiogenesis, migration, and adhesion of various cells. Sebastes schlegelii is a marine viviparous teleost of commercial importance. Previous research has reported abundant blood vessels and connective tissue in the ovary during gestation. In this study, 14 laminin genes of the α, β, and γ subfamilies from genomic data were identified based on zebrafish and human laminins, distributed on 9 chromosomes in S. schlegelii. Analysis of structural domains showed that coiled-coil regions and EGF domains existed in all laminin genes. Moreover, via qPCR, we found that the expression of laminin genes, including lama4, lama5, lamb4, lamc1, and lamc3, gradually increased from the phase III ovary stage and peaked in the early stage of gestation, especially lama4 and lama5 which showed dramatically increased expression at the blastula stage. Accordingly, in situ hybridization of lama4 was conducted. The results revealed that signals became stronger following the phase IV ovary stage, and the strongest signals were located on the follicular pseudoplacenta at the blastula stage. These results suggest that the high expression of laminin genes, especially lama4 after fertilization, may drive cell proliferation, migration, and tissue expansion in the S. schlegelii ovary and ultimately promote follicular pseudoplacenta formation.
All-dielectric optical nanoantennas (Review)

We propose a new type of highly efficient Yagi-Uda nanoantenna and introduced a novel concept of superdirective nanoantennas based on silicon nanoparticles. In addition to the electric response, this silicon nanoantennas exhibit very strong magnetic resonances at the nanoscale. Both types of nanoantennas are studied analytically, numerically and experimentally. For superdirective nanoantennas we also predict the effect of the beam steering at the nanoscale characterized by a subwavelength sensitivity of the beam radiation direction to the source position.
Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis

Introduction Acute kidney injury (AKI) requiring renal replacement therapy is accompanied by considerable mortality. This present study evaluated predictors of mortality at initiation of hemodialysis (HD) in AKI patients in Goma (in the Democratic Republic of the Congo (DRC)). Methods A single-centre cohort survey evaluated the clinical profile and survival rates of AKI patients admitted to HD in the only HD centre in Goma, North Kivu province (DRC). Data were collected from patients who underwent HD for AKI. Patient demographics, comorbidities, clinical presentation, laboratory tests, and mortality were reviewed and analyzed. The survival study used the Kaplan–Meier curve. Predictors of mortality were evaluated using Cox regression. Results Of the 131 eligible patients, the mean age was 43.69 ± 16.56 years (range: 18–90 years). Men represented 54.96% of the cohort. The overall HD mortality rate was 25.19% (n = 33). In multivariate analysis, independent predictors of mortality in AKI stage 3 patients admitted to HD were as follows: age ≥ 60 years (adjusted hazard ratio (AHR) = 15.89; 95% CI: 3.98–63.40; p < 0.0001), traditional herbal medicine intake (AHR = 5.10; 95% CI: 2.10–12.38; p < 0.0001), HIV infection (AHR = 5.55; 95% CI: 1.48–20.73; p=0.011), anemia (AHR = 9.57; 95% CI: 2.08–43.87; p=0.004), hyperkalemia (AHR = 6.23; 95% CI: 1.26–30.72; p=0.025), respiratory distress (AHR = 4.66; 95% CI: 2.07–10.50; p < 0.0001), and coma (AHR = 11.39; 95% CI: 3.51–36.89; p < 0.0001). Conclusion Initiation of hemodialysis with AKI has improved survival in patients with different complications.