Miracle-dz/UniFAR-FTUs huggingface dataset:
Development and Validation of a New UFLC–MS/MS Method for the Detection of Organophosphate Pesticide Metabolites in Urine

To monitor human exposure to pesticides, experts commonly measure their metabolites in urine, particularly dialkyl phosphates (DAPs), which include diethyl phosphate (DEP), Diethyl thiophosphate (DETP), diethyl dithiophosphate (DEDTP), dimethyl phosphate (DMP), dimethyl thiophosphate (DMTP) and dimethyl dithiophosphate (DMDTP)to monitor the metabolites of organophosphates. These DAP metabolites are a urinary biomarker for assessing pesticide exposure and potential health risks. This study presented a new screening method combining ultrafast liquid chromatography with tandem mass spectrometry (UFLC–MS/MS) to detect six DAP metabolites in human urine. The study also compared standard sample extraction methods, namely, liquid–liquid extraction (LLE); quick, easy, cheap, effective, ruggedand safe (QuEChERS); and lyophilization. After a comprehensive analysis of the methods used to extract the analytes, including recovery rate, repeatability and reproducibility, the liquid–liquid extraction (LLE) method was found to be the best. It had a high recovery rate, was easy to handle, required less sample volume and had a short extraction time. Therefore, the LLE method was chosen for further analysis. The results showed excellent performance with high recoveries between 93% and 102%, precise repeatability (RSD) between 0.62% and 5.46% and acceptable reproducibility values (RSD) between 0.80% and 11.33%. The method also had limits of detection (LOD) ranging from 0.0201 ng/mL to 0.0697 ng/mL and limits of quantification (LOQ) ranging from 0.0609 ng/mL to 0.2112 ng/mL. Furthermore, the UFLC–MS/MS method was validated based on the SANTE guidance and successfully analyzed 150 urine samples from farmers and non-farmers. This validated method proved useful for biomonitoring studies focusing on OP pesticide exposure. It offers several advantages, such as a reduced need for samples, chemicals and materials, and a shorter analysis time. The method is sensitive and selective in detecting metabolites in human urine, making it a valuable approach for the practical and efficient assessment of pesticide exposure.
Honokiol-Rich Magnolia officinalis Bark Extract Attenuates Trauma-Induced Neuropathic Pain

Neuropathic pain (NP) affects about 8% of the general population. Current analgesic therapies have limited efficacy, making NP one of the most difficult to treat pain conditions. Evidence indicates that excessive oxidative stress can contribute to the onset of chronic NP and several natural antioxidant compounds have shown promising efficacy in NP models. Thus, this study aimed to investigate the pain-relieving activity of honokiol (HNK)-rich standardized extract of Magnolia officinalis Rehder & E. Wilson bark (MOE), well known for its antioxidant and anti-inflammatory properties, in the spared nerve injury (SNI) model. The molecular mechanisms and efficacy toward neuroinflammation were investigated in spinal cord samples from SNI mice and LPS-stimulated BV2 microglia cells. MOE and HNK showed antioxidant activity. MOE (30 mg/kg p.o.) produced an antiallodynic effect in SNI mice in the absence of locomotor impairment, reduced spinal p-p38, p-JNK1, iNOS, p-p65, IL-1ß, and Nrf2 overexpression, increased IL-10 and MBP levels and attenuated the Notch signaling pathway by reducing Jagged1 and NEXT. These effects were prevented by the CB1 antagonist AM251. HNK reduced the proinflammatory response of LPS-stimulated BV2 and reduced Jagged1 overexpression. MOE and HNK, by modulating oxidative and proinflammatory responses, might represent interesting candidates for NP management.
The Effect of Transcutaneous Posterior Tibial Nerve Stimulation on Pain and Quality of Life in Patients with Fibromyalgia: A Single-Blind, Randomized Controlled Trial

This study aimed to investigate the effectiveness of posterior tibial nerve stimulation (PTNS) in reducing pain, improving quality of life, and decreasing disease severity in patients with fibromyalgia. This prospective, single-blind, randomized controlled trial included female patients newly diagnosed with fibromyalgia who had started duloxetine treatment (30 mg/day). The patients in the study group received six sessions of posterior tibial nerve stimulation, twice weekly, 3–4 days apart, in addition to duloxetine; the controls received duloxetine only. The patients were evaluated three times (at baseline, 1st month, and 3rd month). Pain was evaluated using a numeric rating scale, the short-form McGill Pain Questionnaire, and quality of life with a 36-item short-form health survey (SF-36). Patient functional status and disease severity were evaluated using the fibromyalgia impact questionnaire (FIQ). A total of 64 patients met the inclusion criteria: 22 were ultimately included in the study group and 30 in the control group. Statistical improvements in pain and FIQ scores were observed after treatment in both groups. The SF-36 scores indicated improved vitality only in the 1st month in both groups, with no significant changes in the other quality-of-life subscales in either group. There was no statistical difference between the two groups in terms of changes in pain, FIQ, and SF-36 scores compared with baseline at the 1st month and 3rd month. The addition of PTNS to pharmacological treatment did not contribute to the reduction in pain or improvement in quality of life in fibromyalgia either in the 1st or 3rd month. NIH Clinical Trial Registration Number NCT05937711.
Fisioterapia em grupo na forma de circuit training: um modelo fisioterapêutico para hemiparético crônico: relato de experiência

O objetivo da reabilitacao apos um acidente vascular cerebral e melhorar o desempenho funcional de hemipareticos. A Fisioterapia em Grupo no formato de Circuit Training (FGCT) utiliza exercicios funcionais especificos com foco na repeticao e na progressao continua de exercicios em um numero de estacoes de trabalho organizadas em um formato de circuito, para melhorar a capacidade funcional. O objetivo deste estudo e apresentar as atividades terapeuticas da FGCT e caracteristicas motoras funcionais dos hemipareticos cronicos. Este trabalho indica que a FGCT e uma terapia segura, viavel e aplicavel para hemiparesia cronica, alem disso, pode-se inferir que e um ambiente para o hemiparetico fazer exercicios para prevenir a progressao das suas deficiencias, diminuir a inatividade fisica e se adaptar as limitacoes.
Hydro-acoustic instabilities in compressible turbulent channel flow with porous walls

Submitted for the DFD15 Meeting of The American Physical Society Hydro-acoustic instabilities in compressible turbulent channel flow with porous walls CARLO SCALO1, IMAN RAHBARI2, Purdue University — C. Scalo, J. Bodart, and S. K. Lele, Phys. Fluids (2015) manipulated wall-bounded compressible turbulence by applying impedance boundary conditions (IBC) acoustically tuned to the characteristic time scale of the large-scale eddies. Near-wall turbulence was overhauled by hydro-acoustic instabilities – comprised of coherent spanwise Kelvin-Helmholtz rollers driven by Helmholtz-like acoustic resonance – while outer-layer turbulence was left structurally unaltered. We discuss linear modeling results of the observed flow response, supported by new high-fidelity simulations up to transonic bulk Mach numbers. For IBCs with zero reactance, corresponding to a Darcy-like formulation for porous walls, two dominant modes are identified whose Reynolds stress distributions overlap with the impermeable-wall turbulent buffer layer, directly affecting the near-wall turbulence cycle. For the range of wavenumbers investigated, the transition from subcritical to supercritical permeability does not significantly alter the structure of the unstable modes, showing that wall-permeability accentuates pre-existing, otherwise stable, modes. Implications on flow control strategies for compressible boundary layers over porous walls are discussed. 1School of Mechanical Engineering 2School of Mechanical Engineering Carlo Scalo Purdue University Date submitted: 01 Aug 2015 Electronic form version 1.4
Radiomics and Radiogenomics in Preclinical Imaging on Murine Models: A Narrative Review

Over the past decade, medical imaging technologies have become increasingly significant in both clinical and preclinical research, leading to a better understanding of disease processes and the development of new diagnostic and theranostic methods. Radiomic and radiogenomic approaches have furthered this progress by exploring the relationship between imaging characteristics, genomic information, and outcomes that qualitative interpretations may have overlooked, offering valuable insights for personalized medicine. Preclinical research allows for a controlled environment where various aspects of a pathology can be replicated in animal models, providing radiomic and radiogenomic approaches with the unique opportunity to investigate the causal connection between imaging and molecular factors. The aim of this review is to present the current state of the art in the application of radiomics and radiogenomics on murine models. This review will provide a brief description of relevant articles found in the literature with a discussion on the implications and potential translational relevance of these findings.
Biodiversity and Stoichiometric Plasticity Increase Pico‐Phytoplankton Contributions to Marine Net Primary Productivity and the Biological Pump

Earth System Models generally predict increasing upper ocean stratification from 21st century warming, which will cause a decrease in the vertical nutrient flux forcing declines in marine net primary productivity (NPP) and carbon export. Recent advances in quantifying marine ecosystem carbon to nutrient stoichiometry have identified large latitudinal and biome variability, with low‐latitude oligotrophic systems harboring pico‐sized phytoplankton exhibiting large phosphorus to carbon cellular plasticity. The climate forced changes in nutrient flux stoichiometry and phytoplankton community composition are thus likely to alter the ocean's biogeochemical response and feedback with the carbon‐climate system. We have added three pico‐phytoplankton functional types within the Biogeochemical Elemental Cycling component of the Community Earth System Model while incorporating variable cellular phosphorus to carbon stoichiometry for all represented phytoplankton types. The model simulates Prochlorococcus and Synechococcus populations that dominate the productivity and sinking carbon export of the tropical and subtropical ocean, and pico‐eukaryote populations that contribute significantly to productivity and export within the subtropical to mid‐latitude transition zone, with the western subtropical regions of each basin supporting the most P‐poor stoichiometries. Subtropical gyre recirculation regions along the poleward flanks of surface western boundary currents are identified as regional hotspots of enhanced carbon export exhibiting C‐rich/P‐poor stoichiometry, preferentially inhabited by pico‐eukaryotes and diatoms. Collectively, pico‐phytoplankton contribute ∼58% of global NPP and ∼46% of global particulate organic carbon export below 100 m through direct and ecosystem processing pathways. Biodiversity and cellular nutrient plasticity in marine pico‐phytoplankton combine to increase their contributions to ocean productivity and the biological carbon pump.
Teaching About Black Lives...Everywhere

If we are to truly realize a vision of a more democratic society, then teaching about Black life and in particular Black Lives Matter, should not constitute a radical act, but rather a moral imperative for social studies educators. Furthermore, when we say [and teach] Black Lives Matter, the Black Diaspora reminds us “to articulate and transcend nation-state boundaries” (Paschel, 2017, p. 28).
Core mass function: a comparison study between Orion A and other massive filamentary clouds.

Abstract As a giant compact filamentary cloud, Orion A has a similar morphology with those more distant filaments in infrared dark clouds as revealed in Herschel surveys. We compared their core mass functions and found a similar power law index of N(>m)∝ m −1.0 for the high-mass end, which may possibly indicates a common case for massive filamentary clouds. We also show that the measured mass function for a certain cloud would largely depend on its distance, thus call for caution in interpreting individual measurements of CMF.
Luttinger-liquid physics in wire and dot geometries

In a first part, I study the electronic transport through a one-dimensional, finite-length quantum wire of correlated electrons (Luttinger liquid) coupled at arbitrary position via tunnel barriers to two semi-infinite, one-dimensional as well as stripe-like (two-dimensional) leads, thereby bringing theory closer towards systems resembling setups realized in experiments. In particular, I compute the temperature dependence of the linear conductance of a system without bulk impurities. The appearance of new temperature scales introduced by the lengths of the overhanging parts of the leads and the wire implies a conductance function which is much more complex than the simple power-law behavior obtained in earlier approaches. My results can be used to optimize the experimental setups designed for a verification of Luttinger-liquid scaling. In a second part, I suggest a setup to study Luttinger-liquid behavior in quantum wires which allows to determine the Luttinger-liquid parameter from two independent measurements: transport through a quantum dot embedded in the wire and the charge on the dot. To this end, I identified novel Luttinger-liquid power-laws in the charging of the dot. In a more technical part, I extended an adaption of the functional renormalization group such that it can be used on correlated electrons in complex geometries like the wire-lead structures described above and arbitrary dot structures coupled to Luttinger-liquid leads.
PENGARUH TERPAAN CHANEL YOUTUBE FITNESSFAQS DAN KREDIBILITAS SUMBER TERHADAP KEBUTUHAN INFORMASI KOMUNITAS BARAMORA STREET WORKOUT

Informasi merupakan suatu pengetahuan yang harus didapatkan oleh setiap individu. Salah satunya adalah informasi mengenai berolahraga. Banyak konten kreator khususnya di YouTube yang membahas tentang olahraga. Salah satu canel YouTube yang membahas tentang olahraga adalah FitnessFAQs. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh terpaan channel YouTube FitnessFAQs dan kredibilitas sumber terhadap kebutuhan informasi komunitas BARAMORA street workout. Penelitian ini menggunakan metode kuantitatif, dan sampel dari penelitian ini adalah seluruh anggota komunitas BARAMORA street workout yang berjumlah 68 responden. Hasil pengujian yang dilakukan tidak terdapat pengaruh antara variabel terpaan channel YouTube FitnessFAQs terhadap kebutuhan informasi komunitas BARAMORA dan terdapat pengaruh antara variabel kredibilitas sumber terhadap kebutuhan informasi komunitas BARAMORA. Sedangkan secara simultan pengaruh terpaan channel YouTube FitnessFAQs dan kredibilitas sumber berpengaruh terhadap kebutuhan informasi anggota komunitas BARAMORA.
Single opsin driven white noise ERGs in mice

Purpose Electroretinograms elicited by photopigment isolating white noise stimuli (wnERGs) in mice were measured. The dependency of rod- and cone-opsin-driven wnERGs on mean luminance was studied. Methods Temporal white noise stimuli (containing all frequencies up to 20 Hz, equal amplitudes, random phases) that modulated either rhodopsin, S-opsin or L*-opsin, using the double silent substitution technique, were used to record wnERGs in mice expressing a human L*-opsin instead of the native murine M-opsin. Responses were recorded at 4 mean luminances (MLs). Impulse response functions (IRFs) were obtained by cross-correlating the wnERG recordings with the corresponding modulation of the photopigment excitation elicited by the stimulus. So-called modulation transfer functions (MTFs) were obtained by performing a Fourier transform on the IRFs. Potentials of two repeated wnERG recordings at corresponding time points were plotted against each other. The correlation coefficient (r2repr) of the linear regression through these data was used to quantify reproducibility. Another correlation coefficient (r2ML) was used to quantify the correlations of the wnERGs obtained at different MLs with those at the highest (for cone isolating stimuli) or lowest (for rod isolating stimuli) ML. Results IRFs showed an initial negative (a-wave like) trough N1 and a subsequent positive (b-wave like) peak P1. No oscillatory potential-like components were observed. At 0.4 and 1.0 log cd/m2 ML robust L*- and S-opsin-driven IRFs were obtained that displayed similar latencies and dependencies on ML. L*-opsin-driven IRFs were 2.5–3 times larger than S-opsin-driven IRFs. Rhodopsin-driven IRFs were observed at −0.8 and − 0.2 log cd/m2 and decreased in amplitude with increasing ML. They displayed an additional pronounced late negativity (N2), which may be a correlate of retinal ganglion cell activity. R2repr and r2ML values increased for cones with increasing ML whereas they decreased for rods. For rhodopsin-driven MTFs at low MLs and L*-opsin-driven MTFs at high MLs amplitudes decreased with increasing frequency, with much faster decreasing amplitudes for rhodopsin. A delay was calculated from MTF phases showing larger delays for rhodopsin- vs. low delays for L*-opsin-driven responses. Conclusion Opsin-isolating wnERGs in mice show characteristics of different retinal cell types and their connected pathways.
Product Quality Augmentation Through Agile Operation: A Critical perspective on Supply Chain Capabilities on Reducing Operations Cost

This study focuses on the impact of product quality improvement and supply chain capabilities on reducing operational costs through agile operation. It highlights the significance of adopting agile operation principles and practices to enhance product quality, optimize supply chain operations, and achieve cost efficiencies. The study underlines the importance of continuous improvement processes, such as Lean Six Sigma, in identifying and eliminating inefficiencies, defects, and waste to improve product quality and reduce costs associated with rework and warranty claims. Additionally, it emphasizes the role of agile supply chain capabilities in minimizing inventory carrying costs, production disruptions, and transportation expenses through efficient inventory management techniques. The research emphasizes that integrating product quality improvement and agile supply chain capabilities drives down operational costs by streamlining processes, reducing waste, and fostering a culture of continuous improvement. Overall, this study highlights the critical role of product quality improvement and supply chain capabilities in reducing operational costs and achieving operational excellence through agile operation practices.
Utilizing Mesenchymal Stem Cells to Improve the Healing Process of the Medial Collateral Ligament in the Knee

The healing process of the medial collateral ligament (MCL) in the knee is often slow, resulting in adverse outcomes such as scar tissue formation, joint instability, limited range of motion, and an increased risk of re-injury. Consequently, novel therapeutic strategies are imperative to enhance MCL healing. Mesenchymal stem cells (MSCs) have emerged as a promising treatment modality due to their robust proliferative ability, reparative potential, and ability to differentiate into various cell types. Although preclinical studies have shown encouraging results for MSC-based approaches in MCL injuries, clinical studies in the orthopedic literature remain scarce. This review provides an overview of the MCL, conventional treatments for MCL injuries, and recent advances in MSC research for augmenting MCL healing. MSC-based approaches hold promise as a future therapeutic option to improve MCL healing. Nonetheless, further research is warranted to establish the effectiveness and safety of this emerging treatment modality.
Prediction of AF in ACS Patients Using Different Antiplatelets by Tissue Doppler Derived Atrial Dyssynchrony

: Background: Acute coronary syndromes (ACS) are one of the major causes of mortality and morbidity worldwide. Current guidelines recommend dual antiplatelet therapy in patients with ACS. This study aimed to predict AF in ACS patients using ticagrelor or clopidogrel by tissue Doppler derived atrial Dyssynchrony and to assess the outcome morbidity and mortality in each group. Methods: This was an observational, case series, single center study, was carried out at coronary care unit at “Benha University hospital” on 200 patients with ACS (STEMI & NSTE-ACS), 100 of the patients used ticagrelor and the other 100 patients used clopidogrel, in the period from June 2022 to December 2022. Results: The incidence of AF was insignificantly different between the studied groups. LAVI max and Mitral regurgitation was significantly higher in New‐onset AF patients (P value=0.024, 0.001 respectively). Tissue Doppler imaging data (Lateral mitral P-A' interval, septal mitral P-As interval, tricuspid P-A' interval, LA Dyssynchrony and Inter-atrial Dyssynchrony) were significantly higher in New‐onset AF patients (P value<0.05). LA Dyssynchrony can significantly predict the incidence of AF with AUC 0.704 (95% CI: 0.636 - 0.766) and P value = 0.008, at cut off value >7.792 ms, with 68.2 % sensitivity, 63.5 % specificity, 18.7 PPV and 94.2 NPV. LV GLS was significantly lower in New-onset AF patients (P value =0.035). Conclusion: Our study showed that there was no significant difference in electro-echocardiographic AF predictors such as PWD, LAVI max, left atrial dyssynchrony and interatrial dyssynchrony in ACS patients who received ticagrelor or clopidogrel.
The Military Reforms and Achievements of Alauddin Khilji

Alauddin Khilji, the ruler of the Delhi Sultanate in medieval India, faced numerous military challenges during his reign. These challenges included defending against Mongol invasions, suppressing internal rebellions, expanding the boundaries of the Sultanate, and overcoming logistical obstacles. To address these challenges, Khilji implemented significant military reforms, such as establishing a standing army, implementing strict disciplinary measures, introducing the branding system for horses, and constructing strategic forts. These reforms played a crucial role in consolidating his power, expanding the Sultanate's territory, ensuring the effectiveness of the armed forces, and strengthening the stability of the Delhi Sultanate. Khilji's military strategies and decisions, including his aggressive expansionist policy and emphasis on defense, intelligence gathering, and resource utilization, contributed to his military successes and reshaped the socio-political dynamics of the Sultanate.