Miracle-dz/UniFAR-FTUs huggingface dataset:
Recent Advances in Insulin Delivery Devices and Modes of Insulin Therapy

The discovery of insulin was 100 years old till 2021. Insulin, the first diabetic medication, is now the safest and most effective glucose-lowering medication available. Despite its efficacy, the most significant challenge with insulin has been the prevalence of hypoglycemia, which has resulted in the majority of patients being prescribed optimum dosages. Insulin delivery devices include syringes, pens, and pumps. Soon, artificial pancreas (AP) by using a very closed-loop delivery method will be a big step towards the advancement of insulin delivery devices. This article looks at the invention of syringes, disposable, long-lasting pens, and smart connected pens, continuous intraperitoneal insulin infusion (CIPII) and patch insulin pumps, artificial pancreas and other medical devices. Hence, insulin administration that is both minimally invasive and non-invasive towards the advancement is required. We review the available information on the evolution of insulin delivery systems, focusing on the advantages and disadvantages of technology as well as anticipated advances. Due to the wide variety of technological solutions accessible via the international platform, only the most common methods essential to the patient’s care are detailed here in the article.
22 Tracking the Careers of Grape and Wine Polymers Using Biotechnology and Systems Biology

The grapevine is the world’s most important agricultural fruit crop with 7,861,000 hectares of vineyards worldwide in 2008 and about 270 million hL of wine produced annually (OIV, 2009). Wine, an alcoholic beverage that dates back thousands of years, predating the Greek and Roman empires, is currently believed to have originated in the Middle East. Vitis vinifera, the cultivated grapevine, is a native species of the Caucasus, a mountainous region in Eurasia, and has become the primary fruit crop used for winemaking worldwide. Winemaking has traditionally been considered an art and wine itself conjures up romantic images of farmers laboring in trellised vineyards and winemakers working in rustic cellars. The art of winemaking goes hand-in-hand with the art of cooking and of fi ne cuisine. The reality could not be further from the truth. Winemaking can be considered as mankind’s fi rst foray into the world of biotechnology. Indeed, wine itself is a product of a biotechnological process which involves the treatment of must (grape juice) with microorganisms, specifi cally with yeast CONTENTS
Switching regulator using a quadratic boost converter for wide DC conversion ratios

A controller design methodology for a quadratic boost converter with a single active switch is developed. This converter has two LC filters; thus, it will exhibit fourth-order characteristic dynamics. However, only the first inductor current and the output capacitor voltage are selected for feedback purposes. This current can also be used for one-cycle overload protection; therefore, the full benefits of current-mode control are maintained. Average current-mode control is selected over peak current-mode control because this strategy provides a faster transient response and better noise immunity. The high-gain compensator of the current loop helps tracking the current programme with a high degree of accuracy. The robustness of the proposed controller is tested under changes in the input voltage, output load and reference signal.
On a Method of Supplying Community Facilities in Residential Areas in New Towns

Abstract This research aims at clarifying methods of supplying community facilitites in new towns by devising a plan which prepares spaces open in residential areas in advance where some facilities can be developed. We developed a model that calculates the number of facilities built in those spaces using the theory of quantification, after we surveyed several new towns that have been already developed and where some unplanned shops have been located. Since the model can explain the actual locations of the facilities in those new towns, we made a case study on a prediction of facilities development using the model of the Seishin-Minami New Town. Compared with the surveyed new towns and our prediction in Seishin-Minami New Town, we found that it has more community facilities in the residential areas; this result proves the effect of the preparatory development. In conclusion, it is important to supply basic commercial facilities by leaving spaces open in the residentail areas in new town projects.
5G Infrastructure Network Slicing: E2E Mean Delay Model and Effectiveness Assessment to Reduce Downtimes in Industry 4.0

Fifth Generation (5G) is expected to meet stringent performance network requisites of the Industry 4.0. Moreover, its built-in network slicing capabilities allow for the support of the traffic heterogeneity in Industry 4.0 over the same physical network infrastructure. However, 5G network slicing capabilities might not be enough in terms of degree of isolation for many private 5G networks use cases, such as multi-tenancy in Industry 4.0. In this vein, infrastructure network slicing, which refers to the use of dedicated and well isolated resources for each network slice at every network domain, fits the necessities of those use cases. In this article, we evaluate the effectiveness of infrastructure slicing to provide isolation among production lines (PLs) in an industrial private 5G network. To that end, we develop a queuing theory-based model to estimate the end-to-end (E2E) mean packet delay of the infrastructure slices. Then, we use this model to compare the E2E mean delay for two configurations, i.e., dedicated infrastructure slices with segregated resources for each PL against the use of a single shared infrastructure slice to serve the performance-sensitive traffic from PLs. Also we evaluate the use of Time-Sensitive Networking (TSN) against bare Ethernet to provide layer 2 connectivity among the 5G system components. We use a complete and realistic setup based on experimental and simulation data of the scenario considered. Our results support the effectiveness of infrastructure slicing to provide isolation in performance among the different slices. Then, using dedicated slices with segregated resources for each PL might reduce the number of the production downtimes and associated costs as the malfunctioning of a PL will not affect the network performance perceived by the performance-sensitive traffic from other PLs. Last, our results show that, besides the improvement in performance, TSN technology truly provides full isolation in the transport network compared to standard Ethernet thanks to traffic prioritization, traffic regulation, and bandwidth reservation capabilities.
Analysis and implementation of a new single-switch buck-boost dc/dc converter

In this study, a novel buck-boost DC/DC converter is presented. The circuit structure of the proposed converter consists of a single power switch, two diodes and some energy storage elements. Employing only a single power switch reduces the implementation cost and switching power losses. The proposed converter has higher voltage gain in step-up mode in comparison with conventional buck-boost and Cuk converter. In addition, this converter expands the continuous conduction mode (CCM) operational region. The presented converter has three operation modes in CCM. The second mode reduces the voltage stresses across the capacitors. Therefore the current stresses on diodes are also reduced. To verify the operation of the proposed converter, the experimental results are provided using a hardware prototype.
Pre- and Perioperative Inflammatory Biomarkers in Older Patients Resected for Localized Colorectal Cancer: Associations with Complications and Prognosis

Simple Summary Colorectal cancer is the second most common cancer worldwide, and the incidence increases with age. The primary treatment for localized disease is surgical resection. Biomarkers identifying older patients at risk of complications following surgery are desirable to create a more individualized treatment plan. The purpose of this study is to investigate if circulating proteins related to inflammation (CRP, Il-6, and YKL-40) can provide information about the risk of complications and survival in older patients undergoing resection, and, furthermore, to investigate if this relation is different in older patients as compared to younger patients. We investigated 401 patients with localized colorectal cancer and found that older patients (n = 210) had higher levels of preoperative inflammatory biomarkers compared to younger patients (n = 191). High levels were associated with major complications after resection in older, but not in younger, patients. This may be useful in the future to design more personalized treatment plans. Abstract The association between pre- and perioperative inflammatory biomarkers, major complications, and survival rates after resection of colorectal cancer (CRC) in older patients is largely unknown. The aim was to investigate age-dependent differences in these associations. Serum CRP, IL-6, and YKL-40 were measured preoperatively and on the first and second day after resection of CRC (stages I–III) in 210 older (≥70 years) and 191 younger patients (<70 years). The results from the complications was presented as an odds ratio (OR, with a 95% confidence interval (CI)) with logistic regression. Results from the mortality rates were presented as a hazard ratio (HR, with a 95% CI) using Cox proportional hazards regression. The preoperative inflammatory biomarkers were higher in the older vs. the younger patients. The risk of complications was increased in older patients with a high preoperative CRP (OR = 1.25, 95% CI 1.03–1.53), IL-6 (OR = 1.57, 95% CI 1.18–2.08), and YKL-40 (OR = 1.66, 95% CI 1.20–2.28), but not in younger patients. Mortality was higher in younger patients with high preoperative YKL-40 (HR = 1.66, 95% CI 1.06–2.60). This was not found in older patients. Elevated preoperative inflammatory biomarkers among older patients were associated with an increased risk of complications, but not mortality. Preoperative inflammatory biomarkers may be useful in assessing the risk of a complicated surgical course in older patients with CRC.
Hybrid linear and circular antenna arrays

The class of Hybrid Linear and Circular Antenna Arrays is presented. The properties of linear and circular antenna arrays are combined to obtain hybrid array types: concentric circular, cylindrical, and coaxial cylindrical antenna arrays. These three types are defined, the expressions of their array factors are derived, their directivities and half power beam widths (HPBW) are simulated. The obtained plots are approximated by curve fitting. Different combinations of excitation currents (e.g. uniform, Chebyshev, Bessel, …) can exist on the elements of the same antenna array.
Data Augmentation Algorithm Based on Generative Antagonism Networks (GAN) Model for Optical Transmission Networks (OTN)

OTN (Optical Transmission Networks) is one of the mainstream infrastructures over the ground-transmission networks, with the characteristics of large bandwidth, low delay, and high reliability. To ensure a stable working of OTN, it is necessary to preform high-level accurate functions of data traffic analysis, alarm prediction, and fault location. However, there is a serious problem for the implementation of these functions, caused by the shortage of available data but a rather-large amount of dirty data existed in OTN. In the view of current pretreatment, the extracted amount of effective data is very less, not enough to support machine learning. To solve this problem, this paper proposes a data augmentation algorithm based on deep learning. Specifically, Data Augmentation for Optical Transmission Networks under Multi-condition constraint (MVOTNDA) is designed based on GAN Mode with the demonstration of variable-length data augmentation method. Experimental results show that MVOTNDA has better performances than the traditional data augmentation algorithms.
Analyse des facteurs de contingence de la comptabilisation des investissements immatériels : cas des entreprises cotées à la Bourse Régionale des Valeurs Mobilières d’Abidjan

Le propos de cette recherche est d’analyser les facteurs de contingence de la comptabilisation des investissements immatériels. A partir d’un échantillon de 23 entreprises non financières cotées sur la BRVM, notre analyse de régression dénote que les entreprises activent les investissements immatériels pour se libérer des contraintes financières imposées par les contrats d’endettement. D’ailleurs, les grandes entreprises sont enclines à activer les investissements immatériels afin d’informer le marché financier sur la qualité de leurs projets contrairement à l’hypothèse des coûts politiques émise par la théorie politico-contractuelle de Watts et Zimmerman (1986).
High-Fidelity Modeling of a Power-Split Plug-In Hybrid Electric Powertrain for Control Performance Evaluation

Plug-in hybrid electric vehicle (PHEV) development seems to be essential for a sustainable transportation system along with electric vehicles. An appropriate power management strategy for a PHEV determines how to blend the engine and the battery power in such a way that leads to significant fuel economy improvement and environmental footprint reduction. To evaluate and validate the controls design, software and hardware-in-the-loop (SIL/HIL) simulations are useful approaches, especially at the early stages of controls design. To conduct SIL/HIL tests, an accurate and relatively fast mathematical model of the real powertrain is required which solely contains the essential dynamics of the plant. In this paper, a physics-based model of a power-split plug-in powertrain is developed and implemented using MapleSim software. This model contains a chemistry-based lithium-ion battery pack, which can distinguish it from other models used in the literature, since the performance of a PHEV greatly depends on its battery. The symbolic computation power of MapleSim makes the model very suitable for real-time SIL/HIL tests.Copyright © 2013 by ASME
Implementation of a Long-Term Bridge Weigh-In-Motion System for a Steel Girder Bridge in the Interstate Highway System

This technical paper discusses the implementation of a long-term bridge weigh-in-motion system for use in determining gross vehicle weights of trucks crossing steel girder bridges. The system uses strain data to determine truck weights using an existing structural health monitoring system installed on a interstate highway bridge. The applied system has the advantage of not using any axle detectors in the roadway; and instead all analyses are performed using strain gauges attached directly to the steel girders, providing for a long-term monitoring system with minimal maintenance. Long-term data has been used to demonstrate that this method can be readily applied to gain important information on the quantity and weights of the trucks crossing the highway bridge.
A4GALT Mediated the Glycosylation of B7-H3 in Human Colorectal Cancer Cell Lines

B7-H3 is one of the most important members of the B7/CD28 family, and its expression level is abnormally high in a variety of tumors. B7-H3 inhibits T cell activation via binding to the corresponding receptors on T cells, thereby mediating tumor immune escape. Glycosylation is a common post-translational modification of proteins, which plays an essential role in protein expression patterns and biological functions. Current evidence has shown that the abnormal glycosylation of B7-H3 in tumors is of great significance for protein expression and ligand-receptor binding. Therefore, in-depth exploration of the underlying mechanism of glycosylation modification of B7-H3 is expected to provide new insights for tumor immunotherapy. To investigate the underlying mechanism of glycosyltransferase-mediated glycosylation of B7-H3. Firstly, the CHIPBase database was used to screen glycosyltransferases with a high correlation with the protein expression of B7-H3. Then their siRNAs were designed and synthesized to transfect into cells, and the western blotting assay was performed for further screening. Secondly, the siRNA and overexpression plasmid of the screened glycosyltransferase were respectively transfected into cells to verify the effect on the expression level of B7-H3. Thirdly, the effect of glycosyltransferase on the expression level of B7-H3 was explored by changing its substrate level. Finally, the co-immunoprecipitation experiment was conducted to verify whether protein binding existed between B7-H3 and the glycosyltransferase. The glycosyltransferase called A4GALT had the highest correlation with the protein expression of B7-H3. After knocking down or overexpressing A4GALT, the protein expression level of B7-H3 both changed significantly. When knocked down GALT to reduce the galactosyl donors, B7-H3 was significantly down-regulated. And B7-H3 was up-regulated while increasing the galactose in the medium. In addition, the Co-immunoprecipitation experiment proved that there was protein binding between B7-H3 and A4GALT. A4GALT can positively regulate the expression of B7-H3, and changing the level of galactosyl donors can also positively regulate the expression of B7-H3. There is a protein interaction between A4GALT and B7-H3.
DO GROUND REACTION FORCES REFLECT TIBIOFEMORAL JOINT LOADING IN ANTERIOR CRUCIATE LIGAMENT DEFICIENT SUBJECTS

INTRODUCTION: Physiological loading imposed on the knee is composed of joint forces that the knee must transmit to support, accelerate and decelerate body mass, and muscle forces acting to control knee motion and provide stability. Although not representing quantification of muscle forces, ground reaction forces (GRF) are often used to estimate knee loading, particularly in studies examining injury mechanisms such as anterior cruciate ligament (ACL) rupture. The purpose of this study was to examine the relationship between GRF and tibiofemoral forces generated by control and ACL deficient (ACLD) patients during a task known to stress the knee, namely abrupt deceleration. METHODS: Eleven functional chronic unilateral ACLD patients and 11 uninjured matched controls landed in single-limb stance on a Kistler force platform after catching a chest level pass and then decelerating abruptly. Sagittal plane kinematics of each subject’s landing action were digitized (200 Hz) and GRF data were sampled (1000 Hz) for 3 trials per lower extremity. Joint reaction forces and sagittal planar net moments of force for the knee were calculated using Newtonian equations of motion and inverse dynamics. Tibiofemoral joint shear (FS) and compressive forces (FC) were derived using the method of Kuster et al. (1994). Pearson product moment correlations were calculated between temporal (ms) and magnitude (BW) aspects of the GRF and tibiofemoral force data to determine the relationship between these parameters for the two subject groups, analysed both individually and when the results were combined. RESULTS: Although the relationship between the magnitude of the anteriorposterior (Fx) and vertical (Fy) GRF components and the magnitude of FS and FC was high for controls, it was low for ACLDs (Table 1). However, the time from initial foot-ground contact (IC) to peak Fx was highly related to the time from IC to peak FS in both subject groups. CONCLUSIONS: It was concluded that the magnitude of GRF data should not be used to estimate loading imposed on the tibiofemoral joint in ACLD patients. However, timing of Fx may provide insight into timing of shear forces at the knee during dynamic tasks. Kuster, M. , Wood, G. A. , Sakurai, S. , Blatter, G. (1994). Downhill Walking: A Stressful Task for the Anterior Cruciate Ligament? A Biomechanical Study with Clinical Implications. Knee Surgery, Sports Traumatology, Arthroscopy, 2, 2-7.
Enhancement-mode n-channel GaN MOSFETs fabricated on p-GaN using HfO/sub 2/ as gate oxide

Enhancement-mode n-channel GaN MOSFETs with overlap gate structure using thick SiO 2 as a gate insulator have been fabricated. The maximum transconductance of 45 mS/mm is seven times larger, to our knowledge, than the best-reported value of GaN MOSFETs with SiO 2 gate oxide.
Ad hoc network security

Countermeasures against node misbehavior and selfishness are mandatory requirements in mobile ad hoc networks. Selfishness that causes lack of node activity cannot be solved by classical security means that aim at verifying the correctness and integrity of an operation. In this paper we outline an original security mechanism (CORE) based on reputation that is used to enforce cooperation among the nodes of a MANET.We then investigate on its robustness using an original approach: we use game theory to model the interactions between the nodes of the ad hoc network and we focus on the strategy that a node can adopt during the network operation.As a first result, we obtained the guidelines that should be adopted when designing a cooperative security mechanism that enforces mobile nodes cooperation. Furthermore, we were able to show that when no countermeasures are taken against misbehaving nodes,network operation can be heavily jeopardized.We then showed that the CORE mechanism is compliant with guidelines provided by the game theoretic model and that, under certain conditions, it assures the cooperation of at least half of the nodes of a MANET.
Lithium ion batteries for medical devices

Lithium-ion batteries are being developed for nonimplantable and implantable medical devices. The high voltage, energy density and unique characteristics of this battery system are, in some cases, an enabling technology for the medical device. In other cases, the lithium-ion system provides additional convenience to the patients who use these devices. Especially for implantable medical devices, lithium-ion batteries must be designed and manufactured to the highest standards of quality and reliability. Safety characterization of various cylindrical and prismatic cells has been performed under both electrical and mechanical abuse conditions. Cycle testing at various charge and discharge rates indicates that the lithium-ion battery can function as a safe and effective power source in medical devices.
A model based on Biomimicry to enhance ecologically sustainable design

Sustainable development has become a central part of the agenda in the building design professions; however, in recent years, the concept of ecologically sustainable development has gained ground which aims to balance both economic and environmental facets of sustainability. This has necessitated new approaches to ecological sustainable design that includes ecological facets to design. Such a design approach that draws from ecology as a model in terms of architecture remains elusive. This research explores Biomimicry as a potential approach that help integrate ecological sustainability to design by understanding the natural processes to comprehend its form and the environment within an ecosystem. This study examines Biomimicry theory, and introduces an ecological model, which is most applicable to architecture. This model leads to a theoretical framework that proposes two ways of emulating nature: direct and indirect that identify naturally occurring adaptation and integration processes. The aim and outcome of the framework will ultimately be a design process that enhances ecological sustainability by increasing the applicability of Biomimicry theory into architectural practice.