Miracle-dz/UniFAR-FTUs huggingface dataset:
Running head: MBCT AND POSITIVE EMOTIONS Mindfulness training increases momentary positive emotions and reward experience in adults vulnerable to depression. A randomized controlled trial.

Objective: To examine whether Mindfulness-Based Cognitive Therapy (MBCT) increases momentary positive emotions and the ability to make use of natural rewards in daily life. Method: Adults with a life-time history of depression and current residual depressive symptoms (mean age 43.9 years, SD 9.6; 75 % female; all Caucasian) were randomized to MBCT ( n = 64) or waitlist control (CONTROL; n = 66) in a parallel, open-label, randomized controlled trial. The Experience Sampling Method was used to measure momentary positive emotions as well as appraisal of pleasant activities in daily life during six days before and after the intervention. Residual depressive symptoms were measured using the 17-item Hamilton Depression Rating Scale. Results: MBCT compared to CONTROL was associated with significant increases in appraisals of positive emotion ( b * = .39) and activity pleasantness ( b * =.22), as well as enhanced ability to boost momentary positive emotions by engaging in pleasant activities ( b * =.08; all p < .005). Associations remained significant when corrected for reductions in depressive symptoms, or for reductions in negative emotion, rumination and worry. In the MBCT condition, increases in positive emotion variables were associated with reduction of residual depressive symptoms (all p < .05). Conclusions: MBCT is associated with increased experience of momentary positive emotions, greater appreciation of, and enhanced responsiveness to pleasant daily-life activities. These changes were unlikely to be pure epiphenomena of decreased depression and, given the role of positive emotions in resilience against depression, may contribute to the protective effects of MBCT against depressive relapse.
A CROSS-SECTIONAL EXAMINATION OF THE PREDICTORS OF COMMITMENT IN SKATEBOARDERS by Morgan

Approximately 7.7 million athletes participate in the sport of skateboarding. Skateboarding is one of a collection of sports that are often termed lifestyle, action, or alternative sports. By definition, lifestyle sports are sports in which athletes form exclusive social identities with the culture of the activity. The culture of the lifestyle sport of skateboarding is heavily influenced by music and art. Lifestyle sport athletes also prefer a sport structure that is participant-controlled as opposed to a structure organized and controlled by parents, coaches, and other authority figures. The Sport Commitment Model describes commitment as being theoretically predicted by enjoyment, personal investments, involvement opportunities, involvement alternatives, social constraints, and social support. The purpose of this study was to examine the theoretical determinants of commitment in a skateboard population. Additionally, atheoretical determinants (art, music, and sport structure) were examined as possible predictors of commitment unique to lifestyle sports. Skateboarders (n=68) were recruited at skate parks, a skateboard showcase, and by flyers posted at the university and local skate shops. Participants completed a modified and adapted Athletes’ Opinion Survey designed to measure commitment and the determinants of commitment. Data were analyzed using hierarchical regressions. Enjoyment (β= .51) was the strongest predictor of commitment in the regression model. Secondly, social support (β=.23), personal investment (β=.31), and involvement opportunities (β=.29) significantly predicted commitment. Involvement
CREATION OF DIGITAL SECURITY COMPONENTS FROM ELECTROENCEPHALOGIC SIGNALS

: In a technological environment such as the current one, in which all daily digital tools are within the reach of a digital device, facilitating immediate access to information, various security tools in the area of information are implemented day by day based on in algorithms of various kinds, including both hardware and software tools; specifically, the tools of daily use such as: mail, social networks, education, banking applications allow the interconnection of multiple devices and thus have the availability of information in an interconnected manner, which implies a good level of aspects such as authentication and security management, key factors required to guarantee the availability, security and fidelity of information in an interconnected environment, promoting the creation of new security methods and paradigms.
Microgrid Cyber-Security | Encyclopedia

Stuxnet, the worm that caused the first reported cyber-physical incident, was discovered by a senior researcher at Kaspersky Lab, Roel Schouwenberg, in June 2010. With a purpose that was beyond stealing, erasing or modifying data, Stuxnet endeavored to cause material sabotage in the supervisory control and data acquisition (SCADA) system as a physical industrial control system. It was regarded as the first cyber-warfare weapon to encompass a complex piece of malware that has infected an estimated 50,000 to 100,000 computers mostly found in Iran, Indonesia, India, and Azerbaijan .
Neutrophil-to-Lymphocyte Ratio and Its Changes are Related to Grade II–IV Glioma Recurrence

Objective: To explore whether the neutrophil-to-lymphocyte ratio (NLR) and its changes are related to tumor recurrence in grade II–IV glioma patients. Methods: One hundred patients who underwent two surgeries (first for diagnosis and the second for recurrence) were retrospectively analyzed. Complete blood count was obtained preoperatively before any treatment. Basic NLR (before the first surgery) and NLR changes were calculated. Tumor recurrence was evaluated by progression-free survival (PFS) using the Kaplan–Meier method. Univariate and multivariate Cox regression analyses were used to determine the potential prognostic factors for PFS. Results: The PFS of patients with high basic NLR (≥4) (median 9 months) was shorter than that of patients with low basic NLR (<4) (median 23 months) ( P = 0.004). Univariate and multivariate analyses both showed that basic NLR (before the first surgery) (≥4 vs <4) was an independent predictor of PFS ( P = 0.011). The PFS is also varied with NLR changes before two surgeries ( P < 0.05). The PFS of patients with two low NLR (<4) at both initial surgical resection and section for tumor recurrence had the longest PSF. The patients with two high NLR (≥4) at both initial surgical resection and section for tumor recurrence had the shortest PSF. The patients with one high NLR (≥4) at initial surgical resection or section for tumor recurrence had an average PSF. Multivariate analysis showed that the change of NLR was of prognostic significance independent of glioma grade. Conclusion: We showed both basic NLR and NLR changes could predict the recurrence of glioma, but the change of NLR is more accurate than that of basic NLR. The current research not only provides a simple and feasible method for clinical judgment of glioma recurrence but also provides a new idea for exploring the mechanism of glioma recurrence.
SURVELLIANCE OF BOVINE MILK SAMPLES AND DETERMINED ITS IMMUNOLOGICAL ACTIVITY OF LACTOFERRIN

the Milk is a very complex product and reported more than hundred separate chemical compounds. The major components of milk are water, casein, whey proteins, fat, lactose and minerals. These components should be varied according to the species of various animals. Milk also contains trace amounts of other substances such as pigments, enzymes, vitamins, phospholipids including gases. Once the residue is left only when water and gases are removed is called the dry matter (DM) or total solids content of the milk. In this study, we observed lactoferrin content in milk samples of different bovine animals and also studied about its proliferation and estimation of Th1 (IFN-gamma and TNF alpha) cytokines against non-specific protein antigen (Concanavalin, Con A) in human whole blood samples and also studied about its antibacterial properties using Bacillus subtilis and Pseudomonas aeruginosa . The results of these studies showed that
its Anticancer Drug Development Based on Phytochemicals

Fruits, vegetables and spices form an integral part of daily diet. They have received a great deal of attention from researchers owing to their wide range of disease healing properties. The active components of these natural products contribute to their medicinal properties. Burden of cancer is on the rise and cancer is a major public health concern all over the world. Plant derived compounds or phytochemicals are stud with anti-cancer properties. They are known to be effective in cancer therapy as mechanism of action has been already explored. These plant products are advantageous as they act differentially on cancer cells without affecting the normal cells. There are various modalities of cancer treatment, of which chemotherapeutic drugs is quite popular. However the emerging problem of drug associated toxicity and drug resistance necessitates the development of newer improved anti-cancer drugs. Modifications of chemical structures and computer based modeling might lead to newer drug discovery, but potential of natural products cannot be ignored. Natural plant derived molecules may serve as templates for discovery of new drugs. They may offer a novel and non-toxic way of cancer therapy. A number of plant derived molecules are used as anti-tumor drugs or are undergoing preclinical or clinical trials. Therefore it is time to emphasize on the discovery of anti-tumor drugs based on plant derived molecules.
NDT_A_231573 2191..2208

1Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA; 2Department of Psychiatry, University of Texas-Dell Medical School, Austin, TX, USA Abstract: Catatonia is a serious, common syndrome of motoric and behavioral dysfunction, which carries high morbidity and mortality. Electroconvulsive therapy (ECT) is the definitive treatment for catatonia, but access to ECT for the treatment of catatonia remains inappropriately limited. Catatonia is observable, detectable, and relevant to various medical specialties, but underdiagnosis impedes the delivery of appropriate treatment and heightens risk of serious complications including iatrogenesis. Current understanding of catatonia’s pathophysiology links it to the current understanding of ECT’s mechanism of action. Definitive catatonia care requires recognition of the syndrome, workup to identify and treat the underlying cause, and effective management including appropriate referral for ECT. Even when all of these conditions are met, and despite well-established data on the safety and efficacy of ECT, stigma surrounding ECT and legal restrictions for its use in catatonia are additional critical barriers. Addressing the underdiagnosis of catatonia and barriers to its treatment with ECT is vital to improving outcomes for patients. While no standardized protocols for treatment of catatonia with ECT exist, a large body of research guides evidence-based care and reveals where additional research is warranted. The authors conducted a review of the literature on ECT as a treatment for catatonia. Based on the review, the authors offer strategies and future directions for improving access to ECT for patients with catatonia, and propose an algorithm for the treatment of catatonia with ECT.
Exploring Curvilinear Relationship between Entrepreneurial Orientation and Firm Performance

Objective - The vital role of entrepreneurial orientation (EO) on firm performance has been widely studied in developed countries. Most studies have found a positive linear relationship between EO and firm performance. However, the empirical findings are inconclusive. According to the recent literature, one possible reason for these inconsistent findings may be the nature of the relationship between EO and firm performance is not linear as assumed by many researchers. The objective of this study is to examine the relationship between EO and firm performance and specially to determine the best representation is whether linear or curvilinear. Methodology/Technique - This study utilizes a sample of 580 small medium enterprises (SME's) from two provinces in Sri Lanka and hierarchical regression analyses was employed for analyzing the relationships. Findings - Findings demonstrate an S-shape curvilinear relationship between EO and firm performance in the context of SME's in Sri Lanka.
Upstream elements present in the 3’UTR of collagen genes influence the processing efficiency of overlapping polyadenylation signals

3’ untranslated regions (UTRs) of genes often contain key regulatory elements involved in gene expression control. A high degree of evolutionary conservation in regions of the 3’UTR suggests important, conserved elements. In particular, we are interested in those elements involved in regulation of 3’ end formation. In addition to canonical sequence elements, auxiliary sequences likely play an important role in determining the polyadenylation efficiency of mammalian pre-mRNAs. We identified highly conserved sequence elements upstream of the AAUAAA in three human collagen genes, COL1A1, COL1A2, and COL2A1, and demonstrate that these upstream sequence elements (USEs) influence polyadenylation efficiency. Mutation of the USEs decreases polyadenylation efficiency both in vitro and in vivo , and inclusion of competitor oligoribonucleotides representing the USEs specifically inhibit polyadenylation. We have also shown that insertion of a USE into a weak polyadenylation signal can enhance 3’ end formation. Close inspection of the COL1A2 3’UTR reveals an unusual feature of two closely spaced, competing polyadenylation signals. Taken together, these data demonstrate that USEs are important auxiliary polyadenylation elements in mammalian genes.
The Association between Trp 64 Arg Polymorphism of the b 3 -Adrenergic Receptor and Autonomic Nervous System Activity*

The b 3 -adrenergic receptor plays a significant role in the control of lipolysis and thermogenesis in brown adipose tissue through autonomic nervous system (ANS) activity. As the Trp 64 Arg polymorphism of the b 3 -adrenergic receptor gene might affect ANS activity, we investigated the association of the polymorphism with ANS activity. The prevalence of the polymorphism was determined in 204 subjects. Ten normal homozygous, 10 heterozygous, and 1 variant homozygous subjects were examined for ANS activity during supine rest and standing by electrocardiogram R-R interval power spectral analysis. Subjects with the variant did not differ from subjects without the variant in body mass index, plasma glucose, plasma insulin, or family history of diabetes or obesity. The total power of heterozygotes at supine rest was lower than that of normal subjects (1124.6 6 191.6 vs. 3029.8 6 758.8 ms 2 ; mean 6 SE ). With a postural change to standing, the parasympathetic and sympathetic nervous system activity indexes of heterozygotes showed a higher response than those of normal subjects (parasympathetic nervous system index, 0.10 6 0.02 vs. 0.17 6 0.02; sympathetic nervous system index, 10.55 6 1.47 in total power disappeared. These findings show that subjects with the variant, the heterozygotes, lower resting ANS activity normal
Progress in Adaptive Electrical Capacitance Tomography

Electrical Capacitance Tomography (ECT) is a sensing modality commonly used to find the dielectric permittivity distribution inside a region of interest (RoI) from the boundary electrode capacitance measurements. ECT find applications in various industrial processes due to its low-cost and noninvasive/nonintrusive nature. The ECT reconstruction problem is inherently nonlinear, and the imaging resolution is limited by the soft-field nature and limited number of measurements (due to minimum electrode size constraints to provide a given SNR) enabled by the capacitance measurement system. In order to increase the number of measurement without degrading SNR, adaptive electrical capacitance tomography (AECT) and its 3-D variant adaptive electrical capacitance volume tomography (AECVT) are introduced. The proposed adaptive strategy is based on the manipulation of synthetic electrodes comprised of a set of smaller physical electrodes (segments) enabled by AECT/AECVT hardware. AECT increases the number of measurements; however, the increased amount of correlation between different measurements makes the inverse problem (image reconstruction) more ill-conditioned. Spatially adaptive reconstruction techniques (SART) are introduced that take advantage of the Laplacian nature of the interrogating field in AECT/ECT by utilizing synthetic electrodes based on different segment partition sizes while reconstructing in different portions of the RoI. The reconstruction can be sequentially performed starting from the peripheral region of ii the RoI, where the achievable resolution is higher, towards the center region of the RoI. SART also makes it possible to use different AECT sensing modes together to achieve higher spatial and radiometric resolution as well as to ameliorate some the nonlinear artifacts. The simultaneous activation of multiple electrodes can be advantageous to manipulate the sensing field distribution and capture more spatial information for imaging purposes. However, conventional methods for sensitivity map computation in ECT are inadequate in the presence of multielectrode activation because the mutual coupling between electrodes is not properly accounted for. This coupling becomes especially critical in adaptive electrical capacitance volume tomography (AECVT) sensors, where signals from many small electrode segments are combined into synthetic electrodes. To address this issue, a more general approach is presented for sensitivity map computation in AECVT.
BIROn - Birkbeck Institutional Research Online Potential gain as a centrality measure.

Navigability is a distinctive features of graphs associated with artificial or natural systems whose primary goal is the transportation of information or goods. We say that a graph G is navigable when an agent is able to efficiently reach any target node in G by means of local routing decisions. In a social network navigability translates to the ability of reaching an individual through personal contacts. Graph navigability is well-studied, but a fundamental question is still open: why are some individuals more likely than others to be reached via short, friend-of-a-friend, communication chains? In this article we answer the question above by proposing a novel centrality metric called the potential gain, which, in an informal sense, quantifies the easiness at which a target node can be reached. We define two variants of the potential gain, called the geometric and the exponential potential gain, and present fast algorithms to compute them. The geometric and the potential gain are the first instances of a novel class of composite centrality metrics, i.e., centrality metrics which combine the popularity of a node in G with its similarity to all other nodes. As shown in previous studies, popularity and similarity are two main criteria which regulate the way humans seek for information in large networks such as Wikipedia. We give a formal proof that the potential gain of a node is always equivalent to the product of its degree centrality (which captures popularity) and its Katz centrality (which captures similarity).
LYMPHOID NEOPLASIA Noninvasive monitoring of diffuse large B-cell lymphoma by immunoglobulin high-throughput sequencing

shown limited utility of routine surveillance imaging for diffuse large B-cell lymphoma (DLBCL) patients achieving remission. Detection of molecular by immunoglobulin high-throughput sequencing (Ig-HTS) from peripheral blood provides an alternate strategy for surveillance. We prospectively evaluated the utility of Ig-HTS within 311 blood and 105 tumor samplesfrom 75 patients with DLBCL, comparing Ig-HTS from the cellular (circulating leukocytes) and acellular (plasma cell-free DNA) compartmentsofperipheralbloodtoclinicaloutcomesand 18 fluoro-deoxyglucosepositron emissiontomographycombinedwithcomputedtomography(PET/CT;n 5 173). Clonotypic immunoglobulin rearrangements were detected in 83% of patients with adequate tumor samples to enable subsequent monitoring in peripheral blood. Molecular disease measured from plasma, compared with circulating leukocytes, was more abundant and better correlated with radiographic disease burden. Before treatment, molecular disease was detected in the plasma of 82% of patients compared with 71% in circulating cells ( P 5 .68). However, molecular disease was detected significantly more frequently in theplasmaattimeofrelapse(100%vs30%; P 5 .001). DetectionofmoleculardiseaseintheplasmaoftenprecededPET/CTdetectionof relapse in patients initially achieving remission. During surveillance time points before relapse, plasma Ig-HTS demonstrated improved specificity (100% vs 56%, P < .0001) and similar sensitivity (31% vs 55%, P 5 .4) compared with PET/CT. Given its high specificity,Ig-HTSfromplasmahaspotentialclinicalutilityforsurveillanceaftercompleteremission. ( Blood .2015;125(24):3679-3687) performed by Fisher ’ s exact test, ordinal variables including Ann Arbor stage and International PrognosticIndex(IPI)by x 2 test,andpatientage byStudent t test.Pearson correlation was used to compare Ig-HTS to MTV. The analytical sensi- tivity of the LymphoSIGHT assay was estimated at detection of 1 clonal molecule in a background of 1 3 10 6 nonclonal molecules. As the average input into the Ig-HTS reaction for peripheral blood mononuclear cells was1.03 3 10 6 genomes,thenominalsensitivityforthisassayis1in1 3 10 6 . For detection of plasma molecular disease (ie, ctDNA), the average input into the Ig-HTS reaction was 2.18 3 10 3 genomes; therefore, the nominal sensitivity of Ig-HTS on plasma is ; 1 in 2.18 3 10 3 . Sensitivity and speci ﬁ city of Ig-HTS and PET/CT were calculated in comparison with eventualclinicaloutcomeasthegoldstandardinpatientsachievingcomplete remission, over a median follow-up time of 34.2 months. Median follow-up from diagnosis for the entire cohort was 22.6 months (range, 0.7-285.2 months).
Impacts for whom? Assessing inequalities in NSF-funded broader impacts using the Inclusion-Immediacy Criterion

Broader impacts (BI) policies generate debate on the purpose of science, measuring the impact of research, and is an important topic for the science policy community. However, BI policies often fail to determine if R&D funding helps marginalized communities. This paper introduces a new framework, the Inclusion-Immediacy Criterion, that assesses who benefits from research impacts as divided into three groups: (1) advantaged groups; (2) the general population; and (3) marginalized groups. The study analyzes National Science Foundation (NSF) project outcome reports and finds that advantaged groups are the most likely to benefit from NSF-funded research. The study also shows that certain areas of NSF research, such as Social, Behavioral, and Economic Sciences, more efficiently generate impacts for marginalized groups compared to other directorates. This paper further argues that persistent inequalities in BIs limit the potential of R&D to increase prosperity and well-being, two of NSF’s mandated goals. of research results for non-academic audiences in any form (web site, seminars, meetings, and K-12 outreach Partnerships with potential users of research results Includes partnerships with bodies,