Miracle-dz/UniFAR-FTUs huggingface dataset:
Biomolecular screening for inhibitors of butyrylcholinesterase : identification and characterization using in vitro and in silico tools

i LIST OF ORIGINAL PUBLICATIONS . ii CONTRIBUTIONS OF THE AUTHOR . iii ACKNOWLEDGEMENTS . iv ABBREVIATIONS . vi 1 REVIEW OF THE LITERATURE . 1 1.1 Cholinesterases . 1 1.1.1 Acetylcholinesterase . 1 1.1.2 Butyrylcholinesterase . 3 1.1.3 Structural differences in the active site . 4 1.2 Cholinesterases as targets in drug discovery . 4 1.2.1 Dementia: Alzheimer’s disease . 5 1.2.1.1 Current therapies . 8 1.2.1.2 Importance of biomarkers for AD . 10 1.3 The early drug discovery process . 11 1.3.1 Screening approach . 12 1.3.2 The screening approach during this thesis . 13 2 AIMS OF THE STUDY . 17 3 MATERIALS AND METHODS . 18 3.1 Compound libraries . 18 3.1.1 Synthetic compound libraries (I and II) . 18 3.1.2 Enzo library (III) . 18 3.1.3 Cinchona alkaloids (IV) . 18 3.2 Biochemical assays (in vitro) . 19 3.2.1 Ellman’s reaction (I-IV). 19 3.2.1.1 Potency determination (I-IV) . 19 3.2.1.2 Kinetic measurement (I-IV) . 20 3.2.2 Thioflavin T (I and III) . 20 3.2.2.1 Disaggregation of Aβ (III) . 21 3.2.2. 2 AChE induced aggregation (III) . 21 3.2. 3 In vitro cytotoxicity assay (I, II and IV) . 21 3.3 Computational methods (in silico) . 22 3.3.1 Molecular docking (II, III and IV) . 22 3.3.2 ChemGPS-NP (I-IV) . 23 3.3.3 Statistical analysis (I-IV) . 23 4 RESULTS . 25 4.1 Assay performance (I-IV) . 25 4.2 Primary cholinesterase screening results (I-IV) . 26
RC sequence asymmetric polyphase networks for RF integrated transceivers

Resistance-capacitance (RC) sequence asymmetric polyphase networks have recently gained a renewed interest in the design of radio-frequency integrated transceivers. These networks provide an efficient way for wideband quadrature signal generation with reduced sensitivity to component mismatch. In addition, polyphase networks represent a passive implementation of complex analog filters used for image signal suppression. The general behavior of this class of networks, as well as their distinct property of discriminating between positive and negative sequences, are discussed and evaluated analytically. A design methodology is proposed and a sensitivity analysis based on Monte Carlo simulation is presented. The effect of the absolute variation of R and C values on the phase and gain matching, as well as on the image signal suppression, is also investigated for one-, two-, and three-stage networks.
Research on manufacturing mirror segments for an extremely large telescope

This thesis concentrates on the development of a process-chain for the manufacture of the mirror segments for the European Extremely Large Telescope (E-ELT). This revolutionary scientific project with a 39.3m primary mirror will be the largest optical/near-infrared telescope in the world. The primary mirror design consists of 798 aspheric hexagonal segments, each 1.44 metres across-corners, but only 50mm thick. The manufacture of these aspheric segments poses many challenges. Edge mis-figure is regarded as one of the most difficult technical issues for segment production, impacting directly on the telescope’s science output, such as the detection of extrasolar terrestrial planets. The other challenge is how to speed up the process for the manufacture of almost 1000 segments in a reasonable time and cost. The 'Precessions' polishing technique is an advanced polishing method with high precision and efficiency. To achieve the specification of E-ELT’s segments, there are some key techniques that need to be researched, such as: edge control, removal of mid-spatial frequency errors and a massive improvement in process speed c.f. classical methods. The research work in this thesis contributed to the delivery of an effective process, including the characterisation of tool influence functions for the 'Precessions' technique; optimisation of the process parameters; edge control; diagnoses of edge asymmetry of hexagonal parts, and speeding-up the whole process. Two process-chains giving substantially different depths of removal have been developed and demonstrated on a hexagonal Zerodur part (200mm across-corners) with edge control, and the results meet the E-ELT specification. As a result, different top-level strategies for addressing the manufacture have been considered, leading to a preferred direction for the research
CAMRAD - A COMPREHENSIVE ANALYTICAL MODEL OF ROTORCRAFT AERODYNAMICS AND DYNAMICS

The Comprehensive Analytical Model of Rotorcraft Aerodynamics, CAMRAD, program is designed to calculate rotor performance, loads, and noise; helicopter vibration and gust response; flight dynamics and handling qualities; and system aeroelastic stability. The analysis is a consistent combination of structural, inertial, and aerodynamic models applicable to a wide range of problems and a wide class of vehicles. The CAMRAD analysis can be applied to articulated, hingeless, gimballed, and teetering rotors with an arbitrary number of blades. The rotor degrees of freedom included are blade/flap bending, rigid pitch and elastic torsion, and optionally gimbal or teeter motion. General two-rotor aircrafts can be modeled. Single main-rotor and tandem helicopter and sideby-side tilting proprotor aircraft configurations can be considered. The case of a rotor or helicopter in a wind tunnel can also be modeled. The aircraft degrees of freedom included are the six rigid body motion, elastic airframe motions, and the rotor/engine speed perturbations. CAMRAD calculates the load and motion of helicopters and airframes in two stages. First the trim solution is obtained; then the flutter, flight dynamics, and/or transient behavior can be calculated. The trim operating conditions considered include level flight, steady climb or descent, and steady turns. The analysis of the rotor includes nonlinear inertial and aerodynamic models, applicable to large blade angles and a high inflow ratio, The rotor aerodynamic model is based on two-dimensional steady airfoil characteristics with corrections for three-dimensional and unsteady flow effects, including a dynamic stall model. In the flutter analysis, the matrices are constructed that describe the linear differential equations of motion, and the equations are analyzed. In the flight dynamics analysis, the stability derivatives are calculated and the matrices are constructed that describe the linear differential equations of motion. These equations are analyzed. In the transient analysis, the rigid body equations of motion are numerically integrated, for a prescribed transient gust or control input. The CAMRAD program product is available by license for a period of ten years to domestic U.S. licensees. The licensed program product includes the CAMRAD source code, command procedures, sample applications, and one set of supporting documentation. Copies of the documentation may be purchased separately at the price indicated below. CAMRAD is written in FORTRAN 77 for the DEC VAX under VMS 4.6 with a recommended core memory of 4.04 megabytes. The DISSPLA package is necessary for graphical output. CAMRAD was developed in 1980.
EXPERIMENTAL AND THEORETICAL STUDY OF THE INFLUENCE OF TIRES ON STRAIGHT-RUNNING MOTORCYCLE WEAVE RESPONSE

The influence of tires on straight-running motorcycle weave oscillation has been studied both experimentally and theoretically. Three sets of front and rear tires were used. The weave oscillation was excited by "Nitrogen gas-jet disturbance system" fitted to the instrumented test vehicle. It was shown that the measured damping ratios of yaw rate were in good agreement with the calculations by the mathematical model in which several tire characteristics were considered. The contribution of each tire coefficient to the damping ratio of the weave mode was also examined by parametric studies.
A built-in current sensor for testing analog circuit blocks

A built-in current (BIC) sensor circuit is proposed for supply current (I/sub DD/) testing of analog circuits. The BIC sensor provides high current measurement sensitivity without introducing a large impedance in the I/sub DD/ path. The circuit has been implemented using a standard 0.5 /spl mu/m CMOS technology. Circuit performance trade-offs are analyzed and optimization guidelines provided for various applications. Simulation and measurement results are also included.
Mobile and Wireless Communications for IMT-Advanced and Beyond

A timely addition to the understanding of IMT-Advanced, this book places particular emphasis on the new areas which IMT-Advanced technologies rely on compared with their predecessors. These latest areas include Radio Resource Management, Carrier Aggregation, improved MIMO support and Relaying.Each technique is thoroughly described and illustrated before being surveyed in context of the LTE-Advanced standards. The book also presents state-of-the-art information on the different aspects of the work of standardization bodies (such as 3GPP and IEEE), making global links between them.Explores the latest research innovations to assess the future of the LTE standardCovers the latest research techniques for beyond IMT-Advanced such as Coordinated multi-point systems (CoMP), Network Coding, Device-to-Device and Spectrum SharingContains key information for researchers from academia and industry, engineers, regulators and decision makers working on LTE-Advanced and beyond
Mechatronics: an Introduction

What is Mechatronics? Robert H. Bishop and M. K. Ramasubramanian Mechatronic Design Approach Rolf Isermann System Interfacing, Instrumentation, and Control Systems Rick Homkes Microprocessor-Based Controllers and Microelectronics Ondrej Novak and Ivan Dolezal An Introduction to Micro- and Nanotechnology Michael Goldfarb, Alvin Strauss, and Eric J. Barth Modeling Electromechanical Systems Francis C. Moon Modeling and Simulation for MEMS Carla Purdy The Physical Basis of Analogies in Physical System Models Neville Hogan and Peter C. Breedveld Introduction to Sensors and Actuators M. Anjanappa, K. Datta, and T. Song Fundamentals of Time and Frequency Michael A. Lombardi Sensor and Actuator Characteristics Joey Parker The Role of Controls in Mechatronics Job van Amerongen The Role of Modeling in Mechatronics Design Jeffrey A. Jalkio Design Optimization of Mechatronic Systems Tomas Brezina, Ctirad Kratochvil, and Cestmir Ondrusek Introduction to Computers and Logic Systems Kevin Craig and Fred Stol? System Interfaces M.J. Tordon and J. Katupitiya Communications and Computer Networks Mohammad Ilyas Control with Embedded Computers and Programmable Logic Controllers Hugh Jack and Andrew Sterian Introduction to Data Acquisition Jace Curtis Computer-Based Instrumentation Systems Kris Fuller Software Design and Development Margaret H. Hamilton Index
Optimum optical amplifier location in spectrum-sliced WDM passive optical networks for customer access

Summary form only given. Spectrum slicing is an attractive scheme for implementing wavelength-division multiplexing (WDM) passive optical networks (PONs) in the customer access environment. Amplification of signals from the filtered broadband incoherent sources that are typically used in spectrum-sliced PONs is dominated by noise processes to those found in systems using narrow-band laser sources. In this paper we examine the tradeoffs that determine the optimum location of the amplifier that maximizes the power budget for a spectrum-sliced WDM PON that uses incoherent sources.
Management Tips for Calves Fed With Automated Milk Feeders

Automated feeding of calves continues to increase in popularity. These systems allow calves access to liquid feed around the clock in a less laborintensive manner than traditional feeding methods. Advantages of these programs include smaller, more frequent meals for calves; consistency in feeding; detection of sick animals in group housing; reduced labor needs; flexibility in labor needs; increased activity; social stimulation; enhanced growth; and public image. Disadvantages include potential communication of disease among group-housed calves and cross-sucking. On-farm results with automatic feeders are providing evidence that group feeding can work on farms of various sizes and can enhance calf growth.
Information Security Risks for Car Manufacturers based on the In-Vehicle Network

Within this thesis we investigate what information security risks result from the used invehicle network architecture. By combining scientific and empirical data an architectural model is constructed in ArchiMateTM. Using this model we categorize vulnerabilities and identify the group that poses the biggest threat to the informations security within cars. We find that most information security risks are due to the protocols used within cars and the interconnectedness of the various vehicular networks. In order to overcome these risks we suggest the development of new networking protocols that are secure by design. Furthermore, car manufacturers should prepare themselves better for potential crisis situations.
Virtual assembly with physical information: a review

Purpose – The purpose of this paper is to give a comprehensive survey on the physics-based virtual assembly (PBVA) technology in a novel perspective, to analyze current drawbacks and propose several promising future directions. Design/methodology/approach – To provide a deep insight of PBVA, a discussion of the developing context of PBVA and a comparison against constraint-based virtual assembly (CBVA) is put forward. The core elements and general structure are analyzed based on typical PBVA systems. Some common key issues as well as common drawbacks are discussed, based on which the research trend and several promising future directions are proposed. Findings – Special attention is paid to new research progresses and new ideas concerning recent development as well as new typical systems of the technology. Advantages of PBVA over CBVA are investigated. Based on the analysis of typical PBVA systems and the evolution of PBVA, the core elements of the technology and the general structure of its implementatio.
Effects of Drive Train Model Parameters on a Variable Speed Wind Turbine

The wind turbine generator system is the only generator unit in utility network where mechanical stiffness is lower than electrical stiffness or synchronizing torque coefficient. The inertia constants of the wind turbine and generator system have significant effects on the transient stability of the wind generators and the wind farm. This paper investigates the effects of two-mass drive train parameters in a doubly fed induction generator (DFIG) variable speed wind turbine (VSWT). Extensive simulations were carried out using PSCAD/EMTDC considering two strategies. In the first strategy, different values of the wind turbine and generator inertia parameters were investigated. The wind turbine and generator inertia parameters that give best response during transient in the first strategy were used to determine the best shaft stiffness in the second strategy. The simulation results show that high values of the wind turbine and generator inertia parameters could lead to more oscillations, hence takes longer time for the VSWT to become stable during and after the transient. However, the larger the shaft stiffness parameter of the two-mass drive train system for VSWT, the better the response of the VWST and the wind farm system during transient.
Simulation of Intelligent Robot in Boxing Exercises Based on Kinect Sensor

In the continuous development process, robot technology has been widely used in aerospace, medical, education and service industries, and the relationship between robots and humans is getting closer.The improvement of robot intelligence is a process of continuously learning outside knowledge.Since the introduction of human-computer interaction technology in 1959, it has provided more and more technical support for human research robots.This paper first takes Taijiquan as an example, and carries out mechanical analysis and deconstruction of its standard Taiji pusher action, and obtains corresponding action parameterization information;Then, based on the human-computer interaction technology, the human body depth image and the skeleton structure are acquired through the Kinect sensor, and the human joint position data is recorded.The coordinate conversion is sent to the Nao robot, which realizes the imitation learning of the robot's push action on the Taiji.
Responding to change : designing a university for the 21st century

This paper examines the need for universities to develop alternative organisational forms to deliver services which will meet the demands of government, business, and communities for a highly trained, technically skilled, well educated workforce. It postulates that in order to survive in the increasingly competitive tertiary sector, successful universities will need to be efficient, focused, committed to learning and be able to effectively reach beyond space and time. It looks at how communications technology can help forge new links between business and universities to create competitive advantage. Universities are ideally suited to this future but need to change from the traditional bureaucratic forms they have taken. We propose a small, flat organisational structure with a flexible, multi-skilled core, a strong group of strategic partners working on a contractual basis and a supporting resource of part-time flexible labour.
Ethernet for Aerospace Applications - Ethernet Heads for the Skies

One of the goals of aerospace applications is to reduce the cost and complexity of avionic systems. Ethernet is a highly scalable, flexible, and popular protocol. The aerospace market is large, with a forecasted production of over 50,000 turbine-powered aircraft valued at $1.7 trillion between 2012 and 2022. Boeing estimates demand for commercial aircraft by 2033 to total over 36,000 with a value of over $5 trillion. In 2014 US airlines served over 750 million passengers and this is growing over 2% yearly. Electronic fly-by-wire is now used for all airliners and high performance aircraft. Although Ethernet has been widely used for four decades, its use in aerospace applications is just beginning to become common. Ethernet is the universal solution in commercial networks because of its high bandwidths, lower cost, openness, reliability, maintainability, flexibility, and interoperability. However, when Ethernet was designed applications with time-critical, safety relevant and deterministic requirements were not given much consideration. Many aerospace applications use a variety of communication architectures that add cost and complexity. Some of them are SpaceWire, MIL-STD-1553, Avionics Full Duplex Switched Ethernet (AFDX), and Time-Triggered Ethernet (TTE). Aerospace network designers desire to decrease the number of networks to reduce cost and effort while improving scalability, flexibility, openness, maintainability, and reliability. AFDX and TTE are being considered more for critical aerospace systems because they provide redundancy, failover protection, guaranteed timing, and frame priority and are based on Ethernet IEEE 802.3. This paper explores the use of AFDX and TTE for aerospace applications.
FMR1 Gene

The FMR1 gene provides instructions for making a protein called FMRP. This protein is present in many tissues, including the brain, testes, and ovaries. In the brain, it may play a role in the development of connections between nerve cells (synapses), where cell-to-cell communication occurs. The synapses can change and adapt over time in response to experience (a characteristic called synaptic plasticity). FMRP may help regulate synaptic plasticity, which is important for learning and memory. The protein's role in the testes and ovaries is not well understood.
Tracking position control of a linear actuator on distributed control network

Tracking position control of a linear magnetic actuator implemented on distributed control network was studied. In the distributed control system involving a discrete-time controller and a linear magnetic actuator, time delay happens as the controller reads the sensor data or sends out the control input to the actuator located at a remote site. In many cases the time delay is not ignorable, and has significant effect on the control system performance. In order to compensate for the adverse effect of the time delay, the modified Smith predictor was introduced to the control system. The results of simulation and experiment show that the performance of linear magnetic actuator can be improved by augmenting the modified Smith predictor onto the existing control system. With the modified Smith predictor, the position error is reduced and the constant disturbance is suppressed.
Ultrasonography in Assessment of Cervical Lymph Nodes

Background: Cervical lymphadenopathy is one of the most common causes of mass in head and neck region there are various causes of CL common among them are reactive, tuberculosis, metastasis and lymphoma. The present study assessed cervical lymph nodes using Ultrasonography (USG). Subjects and Methods: The present study was conducted on 78 patients who underwent USG of neck of both genders. The cervical lymph nodes classified based on the location in the neck into VII levels according to AJCC classification. Results: Age group 11-20 comprised of 8 cases, 21-30 had 15, 31-40 had 20, 41-50 had 27 and 51-60 had 8 cases. USG showed 40 cases malignant, 27 reactive and 11 tubercular.The difference was significant (P< 0.05). Histopathology showed 34 cases malignant, 32 reactive and 10 tubercular. The difference was significant (P< 0.05). FNAC had sensitivity of 98.2% and specificity of 94.4%, USG had sensitivity of 91.2% and specificity of 86.2%. The difference was significant (P< 0.05). Conclusion: Authors found that ultrasonographic examination proved as a valuable primary investigation to identify lymph nodes.
Anytime-Anywhere: Personalised Time Management in Networking for e-Learning

Personalisation in the provision of higher education (HE) has gained traction driven by socio-economic, demographic, and employment changes in the student population. Concomitant with these changes is the evolving capability and ubiquity of mobile technologies. These developments have resulted in interest in e-learning to accommodate the diverse student population and leverage the power of mobile technologies. To address the changing educational demands ‘anytime-anywhere' personalised e-learning utilising mobile technologies is becoming ubiquitous in the domain of HE, and increasingly e-learning is embracing Web 2.0 technologies to provide networking functionality at both a pedagogic and personal level. Personalisation requires the creation of an individual's profile (termed a context), a context defining and describing a user's current state. This article considers personalised e-learning in a university domain with consideration of networking (in a collaborative and social networking sense). Following consideration of the factors driving the interest in and take-up of e-Learning (in a mobile context) Web 2.0 technologies will be considered. The nature of context and context and related research is considered followed by a brief overview of the proposed approach which is designed to enable effective personalisation with constraint satisfaction and predictable decision support. The article closes with final observations and conclusions.