Miracle-dz/UniFAR-FTUs huggingface dataset:
Self-Assembling Injectable Hydrogel for Controlled Drug Delivery of Antimuscular Atrophy Drug Tilorone

A two-component injectable hydrogel was suitably prepared for the encapsulation and prolonged release of tilorone which is an antimuscular atrophy drug. The rapid (7–45 s, depending on the polymer concentration) in situ solidifications of the hydrogel were evoked by the evolving Schiff-base bonds between the aldehyde groups of modified PVA (4-formyl benzoate PVA, PVA-CHO, 5.9 mol% functionalization degree) and the amino groups of 3-mercaptopropionate chitosan (CHIT-SH). The successful modification of the initial polymers was confirmed by both FTIR and NMR measurements; moreover, a new peak appeared in the FTIR spectrum of the 10% w/v PVA-CHO/CHIT-SH hydrogel at 1647 cm−1, indicating the formation of a Schiff base (–CH=N–) and confirming the interaction between the NH2 groups of CHIT–SH and the CHO groups of PVA-CHO for the formation of the dynamic hydrogel. The reaction between the NH2 and CHO groups of the modified biopolymers resulted in a significant increase in the hydrogel’s viscosity which was more than one thousand times greater (9800 mPa·s) than that of the used polymer solutions, which have a viscosity of only 4.6 and 5.8 mPa·s, respectively. Furthermore, the initial chitosan was modified with mercaptopropionic acid (thiol content = 201.85 ± 12 µmol/g) to increase the mucoadhesive properties of the hydrogel. The thiolated chitosan showed a significant increase (~600 mN/mm) in adhesion to the pig intestinal membrane compared to the initial one (~300 mN/mm). The in vitro release of tilorone from the hydrogel was controlled with the crosslinking density/concentration of the hydrogel; the 10% w/v PVA-CHO/CHIT-SH hydrogel had the slowest releasing (21.7 h−1/2) rate, while the 2% w/v PVA-CHO/CHIT-SH hydrogel had the fastest releasing rate (34.6 h−1/2). Due to the characteristics of these hydrogels, their future uses include tissue regeneration scaffolds, wound dressings for skin injuries, and injectable or in situ forming drug delivery systems. Eventually, we hope that the developed hydrogel will be useful in the local treatment of muscle atrophy, such as laryngotracheal atrophy.
Analisis Niat Mahasiswa Diploma III Akuntansi Menggunakan Google Classroom

Google Classroom has become a popular e-learning management system in higher education during the covid-19 pandemic. However, successful implementation of Google Classroom requires acceptance by students. This study aims to explain the factors that influence accounting students’ intention to accept Google Classroom This study uses an Extended the Technology Acceptance Model to assess the acceptance and intention to use Google Classroom. Data was obtained from 326 students of Politeknik YKPN Yogyakarta through online questionnaire using Google Form. The Structural Equation Modelling – Partial Least Square approach is used to assess the measurement model and structural model. This study concludes that 1) perceived ease has no effect on students’ intention to use Google Classroom, 2) perceived of ease Google Classroom has a positive effect on perceived usefulness of Google Classroom, 3) perceived usefulness has a positive effect on students’ intention to use Google Classroom, 4) perceived behavioral control does not affect students’ intentions to use Google Classroom, and 5) subjective norms affect students’ intentions to use Google Classroom.
Avaliação dos métodos de Grant, Vora & Weeks e dos mínimos quadrados na determinação do valor incremental do mercado de carbono nos projetos de geração de energia elétrica no Brasil

The objective of this paper is to evaluate the robustness of the Grant, Vora & Weeks and Least Square Monte Carlo Methods when used to evaluate renewable generation projects developed according to the rules of the Kyoto Protocol Clean Development Mechanism. The proposed methodology makes use of the NEWAVE model in order to generate futures dispatch sequences for all generators connected to the Brazilian grid. After that, based on the methodology ACM0002, the uncertainty associated to the time evolution of the project's baseline is considered. Finally, the carbon market' incremental payoff is estimated using the Real Options Approach. In order to do that, the numerical methods previously mentioned are used under the assumption that the behavior of the carbon price is random and that the price follows a Geometric Brownian Motion
The role of edge current-driven modes in ELM activity

We propose a model for edge localized mode (ELM) evolution which goes beyond linear stability arguments by hypothesizing that peeling modes initiate a Taylor relaxation (a constrained minimization of the magnetic energy) of an outer annular plasma region. The relaxation has two effects on peeling mode stability: (a) As the relaxation process proceeds radially inwards it leaves in its wake a Taylor state, which for conventional tokamak ordering is simply a flattened equilibrium toroidal current density. This effect acting in isolation would provide a destabilizing effect (for conventional current profiles the edge current density would increase); (b) The formation of a (negative for conventional current profiles) skin current at the plasma–vacuum interface which has a counteracting stabilizing effect on peeling modes. For a finite relaxed annulus, these two opposing effects can balance and give a configuration that is stable to all possible peeling instabilities. The radial extent of the relaxed region required for stability can be calculated using this balance. This then leads to model predictions for ELM characteristics such as the widths and mode numbers, the magnitude of the attendant energy losses and the natural (deterministic) scatter in these quantities. We compare these model predictions with a number of experimentally observed ELM properties. Further, expanding the governing equations gives analytic expressions for ELM widths in terms of localized edge parameters. Peeling modes can occur even when the critical pressure gradient for the onset of ballooning modes has not been reached. For this reason ‘type III’ ELMs, which typically occur just above the threshold for L–H transitions, may be best described by this model.
A distributed consensus algorithm via LMI-based model predictive control and primal/dual decomposition methods

This paper deals with an output consensus problem of multiple agents and first presents a centralized algorithm for solving it by a model predictive control method based on linear matrix inequalities. It can be shown that the outputs of all the agents controlled by the presented method asymptotically converge to a common point, i.e., consensus point. Then two kinds of algorithms for solving the consensus problem in a decentralized way are presented by using primal and dual decomposition methods. In general, these algorithms require a large number of iterations, i.e., a large number of communications between agents. To cope with this communication burden, a method that can reduce the number of iterations and guarantee the convergence to a consensus point is proposed by exploiting the property that the primal and dual decomposition methods can give upper and lower bounds of the optimal value of the optimization problem to be solved. The numerical example is given to illustrate the effectiveness of the proposed method.
Analysis of Large-Scale Wave Disturbances in the Tropics Simulated by an NCAR Global Circulation Model

Abstract The purpose of this study is to examine the characteristics of equatorial waves identified in simulated atmospheric data by an NCAR global circulation model. The technique of wavenumber-frequency spectral analysis is applied for the time-sequence data at grid points around the latitude circles. Three types of dominant waves are identified by spectral peaks and phases: the atmospheric Kelvin waves, the mixed Rossby-gravity wave, and the Rossby-Haurwitz type of free oscillation. The Rossby-Haurwitz type of free oscillation is at zonal wavenumber 1 with a westward-propagating period of about 5 days. There is no vertical phase tilt for this oscillation. The Kelvin waves are found at wavenumber 1 with an eastward-traveling period of about 24 days and wavenumber 2 with an eastward-traveling period of about 12 days, while the mixed Rossby-gravity wave is found at zonal wavenumber 3 with a westward-traveling period of about 4.61 days. Both types of vertically-propagating waves have a vertical wavelength .
Application and prospect of medicinal plants combined with aerosol inhalation in the treatment of pulmonary diseases

Pulmonary disease has long been a major problem in the world medical community. Common drugs for the treatment of pulmonary diseases, such as albuterol and pirfenidone, have many side effects in clinical use. Therefore, it is of great significance to find new safe drugs to solve the clinical disadvantages of Western medicine. At present, increasing numbers of medicinal plant extracts have been testified to be effective in clinical trials of pulmonary diseases. The unique physiological structure of the lung provides convenience for aerosol inhalation therapy, and avoids adverse reactions caused by oral and injection administration. This review article aims to introduce the application of some medicinal plants in the treatment of lung diseases. The combination of medicinal plants and aerosol inhalation drug delivery system can improve the targeting, safety and effectiveness of drugs. With the development of technology and experience accumulation, aerosol inhalation treatment of medicinal plants brings hope for the treatment of pulmonary diseases.
Monitoring and prevention system of sleep apnea syndrome

Sleep apnea syndrome is a sleep breathing disease. At present, polysomnography has some problems. The patients feel uncomfortable, and manual judgment of sleep breathing events is labor-intensive. This paper provides a portable on-line monitoring and prevention system for sleep apnea syndrome, which can independently distinguish sleep apnea and sleep hypopnea events according to multi-sensor monitoring data, and adopt a variety of correction and adjustment methods to intervene sleep apnea events. The experimental results show that the method proposed in this paper can accurately determine the current sleep breathing state in time, and has clinical application value.
Comparing pre-trained models through classifying lung conditions using chest x-ray

In classifying chest X-rays (CXR), machine learning, particularly transfer learning, has been widely implemented and has demonstrated an excellent range of accuracy. In this study, ResNet-50, ResNet-101, and VGG16, three popular transfer learning models, were compared in a CXR classification task. This study used a dataset containing CXRs of 3616 COVID- 19-positive cases, CXRs of 1345 viral pneumonia cases, CXRs of 6012 lung opacity (non-Covid lung infection) cases, as well as CXRs of 10,192 normal individuals and corresponding lung masks. The study used Keras and TensorFlow to import the pre-trained models and compare them using the exact same training sets, testing sets, and validation sets. The ResNet-50 achieves a classification accuracy of 90%, the ResNet-101 achieves a classification accuracy of 91%, and the VGG16 achieves a classification accuracy of 89%. This research reached the conclusion that ResNet-101 performs better in such image multiclassification tasks. We speculate that this is because ResNet-101 was trained based on residual learning which is easy to optimize.
Comparative Study of Physicochemical Properties of Alginate Composite Hydrogels Prepared by the Physical Blending and Electrostatic Assembly Methods

Alginate hydrogel commonly suffers from defects, such as weak mechanical properties, the shortage of long-term stability in physiological medium and the lack of mammalian cell adhesivity due to its strong hydrophilicity in biomedical application. For this reason, the homogeneous alginate hydrogels (Alg Gel) were successfully prepared by the D-glucono-δ-lactone/hydroxyapatite (HAP/GDL) cross-linking system, and then, the physical blending and alternating electrostatic assembly technology were proposed to fabricate alginate composite hydrogels (Alg-GT, Alg-CS-GT and ALG/GT-CS). The feasibility of the design methods was verified through the comparative analysis of their physicochemical properties and biological activity. In particular, the effects of physical blending and alternating electrostatic assembly technology on the pore structure, mechanical properties, swelling, degradation, cell adhesion and proliferation of composite hydrogels were also investigated. Experimental results showed that the formation of polyelectrolyte complexes by electrostatic assembly between biological macromolecules and the covalent cross-linking of EDC/NHS to GT improved the vulnerability of ion cross-linking, enhanced the mechanical properties and swelling stability of the composite hydrogels, and regulated their pore structure and in vitro biodegradability properties. Furthermore, MC3T3-E1 cells could exhibit good cell adhesion, cell viability and cell proliferation on the alginate composite hydrogels. Among them, Alg-CS-GT showed the best cell proliferation ability and differentiation effect due to its good cell adhesion. In view of the excellent physicochemical properties and biological activity of Alg-CS-GT, it exhibited great potential in biomedical application for tissue engineering.
The role of D1R-MSN in video game addiction and relapse

Drug addiction, or substance use disorder, is caused by interference of drugs with how neurons are sent, received or process neurotransmitters to one another. The use of drugs will cause cravings, and this is due to the stimulation of the brain’s reward system. Video game addiction, or Internet gaming disorder (IGD) is a common phenomenon especially in teenagers. The symptom of video game addiction is similar to drug addiction, which is the craving behavior of the patient. To resolve this issue, researchers have come up with many different solutions. One of the possible solutions is applying low frequency of Deep brain stimulation (DBS) and SCH23990 to the patient. This is a type of treatment for drug addictions, and it can only be done to treat video game addiction if proven that video game addiction and drug addiction have the same mechanism and disordered parts of the brain.
Hybrid mapping parameter estimation using hierarchical structure in object-oriented coding

This paper investigates motion estimation and compensation in object-oriented analysis-synthesis coding. Object-oriented coding employs a mapping parameter technique for estimating motion information in each object. The mapping parameter technique using gradient operators requires high computational complexity. The main objective of this paper is to propose a hybrid mapping parameter estimation method using the hierarchical structure in object-oriented coding. The hierarchical structure employed constructs a low-resolution image. Then six mapping parameters for each object are estimated from the low-resolution image and these parameter values are verified based on the displaced frame difference (DFD). If the verification test succeeds, the parameters and object boundaries are coded. Otherwise, eight mapping parameters are estimated in a low-resolution image and the verification test is again applied to an image reconstructed by estimated parameters. If it succeeds, the parameters and object boundaries are coded, otherwise, the regions are coded by second-order polynomial approximation. Theoretical analysis and computer simulation show that the peak signal to noise ratio (PSNR) of the image reconstructed by the proposed method lies between those of images reconstructed by the conventional 6- and 8-parameter estimation methods with reduction of the computation time by a factor of about four.
The mass distribution in the galactic disc – II. Determination of the surface mass density of the galactic disc near the Sun

Les donnees photometriques et spectroscopiques pour un echantillon de naines K en direction du pole galactique sud sont analysees en utilisant la technique de modelisation des fonctions de distribution decrite dans l'article I des memes auteurs (1989, Mon. Not. R. astr. Soc., 239). La densite de masse superficielle de la masse identifiee peut egalement etre obtenue en integrant la population stellaire pres du Soleil a travers la loi de force derivee et en y rajoutant la quantite observee de gaz interstellaire. La densite de masse superficielle totale du disque galactique derivee de l'analyse dynamique est comparee a la densite de masse superficielle totale identifiee pres du Soleil
The most massive AGB stars

Abstract The general properties of stars in the mass range 7–12M⊙, also referred to as super-AGB stars, are reviewed and special attention is paid to determine how their mass range depends on the initial metallicity and what fraction of these stars end their life as ONe white dwarfs or explode as electron-capture supernova.
Velocidade da Marcha e Força de Preensão Manual: Indicadores das Condições Físicas de Idosos Submetidos à Avaliação para Habilitação Veicular

O aumento da população idosa gera, consequentemente, um crescimento de idosos que dirigem veículos; desse modo, há uma preocupação com as condições físicas desses motoristas, diante de possíveis riscos no trânsito. O presente estudo teve como objetivo identificar a velocidade da marcha (VM) e a força de preensão manual (FPM) de idosos submetidos à avaliação para habilitação veicular. Trata-se de um estudo de transversal descritivo. Participaram do estudo 63 idosos (≥60 anos) que realizaram os exames para renovação da Carteira Nacional de Habilitação, em uma clínica de trânsito. Os idosos apresentaram idade entre 60 e 85 anos (média 67,95±6,23) e em sua maioria, homens 82,5% (n=52). Os resultados mostraram para a VM valores médios de 1,11±0,26 m/ (metros por segundo). Em idosos considerados aptos com restrição para habilitação veicular, a VM média foi de 1,07±0,29 m/s; para os aptos, 1,16±0,21 m/s e, para os inaptos temporariamente, 1,26 m/s. Para a FPM, os valores de média para a mão direita foi de 38,60±4,55kgf; e mão esquerda, 36,24±5,342kgf. Quanto aos categorizados como aptos com restrição, a média da FPM da mão direita foi de 38,96±4,6kgf; e mão esquerda, 37,29±4,6kgf; para idosos aptos essa média para a mão direita foi de 38,63±4,3kgf; e mão esquerda, 35,82±5,5kgf. A FPM e a VM, além de marcadores de saúde, poderão ser consideradas importantes indicadores das condições físicas dos idosos motoristas e utilizadas como variáveis de rastreio e acompanhamento.
ELLIPTIC PSEUDODIFFERENTIAL EQUATIONS AND SOBOLEV SPACES OVER p-ADIC FIELDS

We study the solutions of equations of type f. D;/ uD v, where f. D;/ is a p-adic pseudodifferential operator. Ifv is a Bruhat‐Schwartz function, there exists a distribution E , a fundamental solution, such that uD E v is a solution. However, it is unknown to which function space E v belongs. We show that if f. D;/ is an elliptic operator, then uD E v belongs to a certain Sobolev space, and we give conditions for the continuity and uniqueness of u. By modifying the Sobolev norm, we establish that f. D;/ gives an isomorphism between certain Sobolev spaces.
Exponential H∞ filtering for uncertain discrete‐time switched linear systems with average dwell time: A µ‐dependent approach

In this paper, the problem of exponential H∞ filter problem for a class of discrete‐time polytopic uncertain switched linear systems with average dwell time switching is investigated. The exponential stability result of the general discrete‐time switched systems using a discontinuous piecewise Lyapunov function approach is first explored. Then, a new µ‐dependent approach is proposed, which means the analysis or synthesis of the underlying systems is dependent on the increase degree µ of the piecewise Lyapunov function at the switching instants. A mode‐dependent full‐order filter is designed such that the developed filter error system is robustly exponentially stable and achieves an exponential H∞ performance. Sufficient existence conditions for the desired filter are derived and formulated in terms of a set of linear matrix inequalities, and consequently the minimal average dwell time and the corresponding filter are obtained from such conditions for a given system decay degree. A numerical example is presented to demonstrate the potential and effectiveness of the developed theoretical results. Copyright © 2007 John Wiley & Sons, Ltd.
Beyond Scientificity: Extensions and Diffractions in Post-Normal Science’s Ethos

Sixty years have passed since Merton’s famous publication of “a note on science and democracy,” outlining the scientific ethos via four sets of norms, namely communism, universalism, disinterest­edness, and organized skepticism (CUDOS). Merton’s rationale was that the implementation of this ethos was instrumental in realizing science’s institutional goal: “the extension of certified knowledge. ” Throughout the ensuing decades, Merton’s conception has been at the center of heated debates in the emerging field of science and technology studies. It has also been addressed by em­pirical studies with a view to determine the scale at which CUDOS was supported by scientists them­selves in explicit terms and/or conformed to in their actual practice. Some of these studies also make room for the possibility that CUDOS might have evolved throughout the past decades, incrementally adapting the norm sets. This article contributes to such empirical endeavors. Building on ethno­graphic work at a technology assessment (TA) institute, I find that a distinct shared ethos is tangible in TA’s post-normal science practices—in collaborations with non-scientists as well as with “pure academics. ” A reconstruction of TA’s distinct ethos from my empirical material results in the delin­eation of a post-normal scientific ethos, comprising “extended communism,” “diffracted uni­versal­ism,” “diffracted disinterestedness,” “extended organized skepticism,” “diffracted originality,” and “extended relevance. ” These “extensions” and “diffractions” have ramifications for the organiza­tion of post-normal science and its interaction with academia, publics, and polities.
A Lagrangian Porous Media Mass Transport Model

The mathematical simulation of advective dispersive contaminant transport in groundwater involving large Peclet numbers is subject to numerical difficulties. For most numerical models the computational cost and computer core requirements escalate as the Peclet number increases. A two-dimensional Galerkin finite element model for flow and Lagrangian mass transport in porous media has been developed to alleviate numerical and computational difficulties. The solution methodology involves a linear triangular mesh which tracks along streamlines calculated from a flow equation having the stream function as the dependent variable. A comparison of this model to Eulerian or fixed coordinate type models showed this model to be accurate and stable at a reduced computational effort. For an actual field contamination problem which contains large vertical concentration gradients, the simulated results compared with observed data.
Interpolation inequality of logarithmic type in abstract Besov spaces and an application to semilinear evolution equations

An abstract version of Besov spaces is introduced by using the resolvent of nonnegative operators. Interpolation inequalities with respect to abstract Besov spaces and generalized Lorentz spaces are obtained. These inequalities provide a generalization of Sobolev inequalities of logarithmic type. Uniqueness problems to abstract semilinear evolution equations are also discussed (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)