Miracle-dz/UniFAR-FTUs huggingface dataset:
Ameliorative Effect of Vanillin against Propiconazole Induced Hepatorenal and Testicular Injury in Male Albino Rats

Vanillin commonly used in pharmaceutical industry, food and beverage processing, and in cosmetics and perfumes preparation. To better understand the effects of vanillin in reduction of tissue injuries resulted from Fungicides misuses. Fungicides like propiconazole are used extensively in greenhouse nowadays. The hazard effects of mycotoxin occurrence affect all defense and immunocytes of animals and reduced its production. But safety of use of fungicide and develop of new generation of fungicide often take a focus from researchers and authority. Propiconazole treatments at different doses have no effect on body weight. Notably, vanillin treatment reduced toxic effects of propiconazole induced in male rats’ evidence by liver and kidney biomarkers and improvement level of antioxidants level. Also, vanillin restored tissue architecture nearly similar to control group. Taken collectively, vanillin had a protective role against propiconazole induced toxicity. Ameliorative Effect of Vanillin against Propiconazole Induced Hepatorenal and Testicular Injury in Male Albino Rats ARC Journal of Animal and Veterinary Sciences Page | 13 2. MATERIALS AND METHODS 2.1. Tested Chemical propiconazole was obtain from institute for pesticide residues analysis in Doky, ministry of agriculture, Egypt. Vanillin was purchase from sigma Cairo, Egypt 2.2. Laboratory Animals 40 Mature males’ albino rats were obtained from Experimental Unit in the Faculty of Pharmacy, Mansoura University; Animals were weighing about 100 ±10 gm and obviously healthy then were grouping and housing in plastic cages with soft wood shavings as a bedding material that change adequately to ensures a low level of ammonia and to keep animals clean and dry. Animals kept for 2 weeks for accommodation and maintained on a balanced ration before the start of the experiment. Also, standard laboratory pelleted diet and water WERE received ad libitium throughout the experiment and Light cycles of 12 hours’ light to 12 hours dark seem to be adequate in order to promote rodents' breeding. 2.3. Experimental Design for Toxicity Propiconazole and the Effects of Vanillin Curing Propiconazole Induced Injuries in Male Albino Rats Forty males were separated into five groups with eight rats per group. The first group was received 0.5 ml distilled water and used as control; the second group was administered 150 mg/kg(6), 1/10 LD50), of propiconazole, the third group was gavaged 75 mg/kg (6), 1/20 LD50, of propiconazole, the fourth group was treated with 1/10 LD50 of propiconazole and was give 150 mg/kg of vanillin intraperitoneally, the fifth group was treated with 1/20 of propiconazole and was give 150 mg/kg of vanillin intraperitoneally. Both fungicide and vanillin were received twice per week for 6 weeks. The protocol was approved by Institutional Research Board of faculty of medicine, Mansoura university, Egypt (R.20.07.924) and study was done with agreement with ethical guidelines and the rest of sacrificed rats was discarded safety.
Inside the Postal Bus: My Ride with Lance Armstrong and the U.S. Postal Cycling Team

"From winter training camp in California to the Tour de France "Inside the Postal Bus" offers an accurate behind the scene view of our team. If you have ever wondered what the life of a pro cyclist is like read this book. " - Lance Armstrong. "A great read! " - Phil Liggett. "Inside the Postal Bus" is so descriptive I felt I knew the riders and staff on the team before I actually met them. " - Tom Danielson. If you've ever wondered what life in the U.S. Postal team whirlwind is really like, "Inside the Postal Bus" is your ticket to ride. Michael Barry, Lance Armstrong's teammate since 2002, opens the door and invites you in to share a coffee and meet the guys. Barry, with help from fellow pros George Hincapie and Christian Vande Velde, will take you into the world of the professional cyclist and the final season for America's favorite team, shedding light on the good, the bad, and the ugly sides of the sport. Descriptive stories of the rituals and rigors of the team make this book an entertaining and refreshingly honest look at the riders and life on the road. It is a must-read for fans of the team and the sport.
The influence on billet processing on the mechanical properties of forged 6061 aluminium

The University of Melbourne, in collaboration with the local automotive and forging industry, is undertaking a research project to review the application of light alloys in safety critical automotive applications. The initial research scope was proposed in response to an identified need for component mass reduction. Mass reduction is a highly important objective for automotive design due to the associated improvement in fuel economy, dynamic performance, and emissions. The forging partner light alloy forging as an emerging opportunity to achieve mass reduction in a mode commensurate with their manufacturing capability. This also provided an opportunity to offset a recent loss of business to increasingly competitive casting technologies.
Neural Correlations Between Executive Function and Social Function in Autism Spectrum Disorder: A Mediation Analysis of fMRI

Background: Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with high heterogeneity. The co-occurrence of social deficits and executive dysfunction is frequently reported in individuals with ASD. The present study evaluated the association between social deficit and executive dysfunction in ASD subjects and explored the underlying neural mechanisms that may mediate this association.Methods: A total of 186 patients with ASD, 5-18 years old (10.25 ± 2.72 years old), from the Autism Brain Imaging Data Exchange II database were enrolled in the final sample. Social function was evaluated by the parent-reported Social Responsiveness Scale (SRS), and executive function (EF) was measured by the parent-reported Behavior Rating Inventory of Executive Function (BRIEF). We selected bilateral amygdala, caudate and putamen as regions of interests, and used the region of interest-based resting-state functional connectivity (FC) analysis to explore the shared and specific brain mechanisms underlying EF and social function. The association analysis of EF, social deficits and FC was conducted using linear regression by controlling covariates, including age, gender, full IQ, handedness, and current medication. Results: The result showed that social functions in ASD children and adolescents were positively associated with EF (r = 0.612, p <0.01). Additionally, 14 and 21 FC links were associated with social deficits and executive dysfunction separately, in which five FC links (right amygdala and right inferior frontal gyrus opercular part, left caudate and right supramarginal gyrus, left putamen and right superior frontal gyrus medial orbital, right putamen and left gyrus rectus, and right putamen and left paracentral lobule) were simultaneously correlated with social function and EF in ASD subjects. We also found that connectivity between the right amygdala and right inferior frontal gyrus mediated the effects of EF on social deficit. Limitations: All the included participants in the present study were ASD patients and male participants, which might limit the generalization of our findings.Conclusion: We found a significant association between social deficits and executive dysfunction in ASD subjects. This association might be mediated by FC between the right amygdala and the right inferior frontal gyrus, which may further illustrate the underlying mechanism of ASD and co-occurrence of social deficits and executive dysfunction in this population.
Associations between polygenic risk of substance use and use disorder and alcohol, cannabis, and nicotine use in adolescence and young adulthood in a longitudinal twin study

Abstract Background Recent well-powered genome-wide association studies have enhanced prediction of substance use outcomes via polygenic scores (PGSs). Here, we test (1) whether these scores contribute to prediction over-and-above family history, (2) the extent to which PGS prediction reflects inherited genetic variation v. demography (population stratification and assortative mating) and indirect genetic effects of parents (genetic nurture), and (3) whether PGS prediction is mediated by behavioral disinhibition prior to substance use onset. Methods PGSs for alcohol, cannabis, and nicotine use/use disorder were calculated for Minnesota Twin Family Study participants (N = 2483, 1565 monozygotic/918 dizygotic). Twins' parents were assessed for histories of substance use disorder. Twins were assessed for behavioral disinhibition at age 11 and substance use from ages 14 to 24. PGS prediction of substance use was examined using linear mixed-effects, within-twin pair, and structural equation models. Results Nearly all PGS measures were associated with multiple types of substance use independently of family history. However, most within-pair PGS prediction estimates were substantially smaller than the corresponding between-pair estimates, suggesting that prediction is driven in part by demography and indirect genetic effects of parents. Path analyses indicated the effects of both PGSs and family history on substance use were mediated via disinhibition in preadolescence. Conclusions PGSs capturing risk of substance use and use disorder can be combined with family history measures to augment prediction of substance use outcomes. Results highlight indirect sources of genetic associations and preadolescent elevations in behavioral disinhibition as two routes through which these scores may relate to substance use.
The human in command : peace support operations

Peace support operations have unique characteristics. These operations require attributes of comrnanders and their teams additional to those qualities required to conduct successful combat operations. Materiel, doctrine, and training must be tailored to accomphsh their functions, but it is the quality of the human in command that leads to successful missions in ambiguous situations. What are these qualities and what are the ingredients for effective operations? This book combines personal experiences of commanders, empirical data on peace support issues and theoretical models. It provides the reader with insight into current issues, such as: leadership, mission characteristics, mission preparation and training, operational conditions and processes, multinational cooperation, and the eflectiveness of individual commanders, units, and missions.
Inter‐organizational Quality Management: The Use of Contractual Incentives and Monitoring Mechanisms with Outsourced Manufacturing

Quality‐related incidents involving contract manufacturers (CMs) are becoming increasingly prevalent. The quality management (QM) literature, however, has focused mostly on QM within a single firm. Thus, the need for data‐driven research on managing quality with outsourced production is evident. We investigate the use and effectiveness of external failure penalties and audits of CMs’ facilities to manage inter‐firm quality. Building on agency theory and extant QM literature, this study addresses two research questions: (i) whether the control mechanisms of quality audits and contractual external quality failure penalties are substitutes or complements in use and (ii) whether they are substitutes or complements in their effectiveness at aligning the quality interests of customers and their CMs. Our analysis uses dyadic data gathered from brand‐owning firms and their CMs representing 95 contract manufacturing relationships in Food and Drug Administration (FDA)‐regulated industries. The results indicate that more severe external failure penalties correspond to a lower use of facility audits (i.e., they are substitutes‐in‐use). We also find that both external failure penalties and facility audits have a unique positive effect on the CM's perception of relative quality importance. Finally, some evidence supports the hypothesis that each mechanism is more effective in the presence of the other (i.e., they are complements‐in‐effectiveness).
A Test Programme for Active Vehicle Safety - Detailed Discussion of the eVALUE Testing Protocols for Longitudinal and Stability Functionality

Active safety functions are massively implemented into new vehicle generations and offer a high potential in decreasing road accidents. While testing and rating of passive vehicle safety are based on established and accepted methods and programmes, no test programme is available for active vehicle safety today. Thus, it is difficult to assess the performance of those functions for industry, legislation and further stakeholders. In particular, the end customer cannot judge active safety of different vehicles based on easy-to-understand ratings as they are offered by different NCAP programmes for passive safety. In the authors' opinion, this leads to a relatively low awareness of active safety functions and hinders a higher market penetration. From January 2008 until December 2010, the European research project eVALUE has been working on objective testing and evaluation methods for active safety functions. According to investigated statistics and databases, critical and accident-prone driving situations have been identified that represent the majority of accidents, where active safety functions can come into effect. The methods are mainly based on physical testing of the full vehicle and do not take into account the influence of a single function, but rather the response of the vehicle as such. Intensive physical testing and application of the test protocols was performed in order to validate and improve the methods proposed by the consortium. Another important topic concerns indicators, which show potential to assess the safety benefit by different active safety functions. Here, a major challenge was given by the lack of required input data, i.e. detailed accident statistics. A first set of indicators has been identified and proposed by the project consortium for further investigation. The proposed new and highly needed test programme allows a first assessment of the overall safety performance potential of a vehicle with respect to active safety. However, the eVALUE consortium only defined the test methods while thresholds for specific indicator values and the derivation of final quantitative overall test results are not specified. This is left to the competence of every institution adopting the test methods and actually applying them in order to assess different vehicles. The authors believe that results gained from the programme will increase the public awareness for active safety functions and foster the development within the industry. However, the project partners also identified and expressed additional research need beyond the scope of the project, e.g. regarding accident statistics and driver behaviour models.
New inertial actuator provides isolation and stabilization in microgravity conditions

Experiments in materials and fluids processing have been conducted, or are planned, that take advantage of the low-g environment offered by space-based platforms. While the specific goals of the experiments vary, a common objective is to see improved results from the processes over those that would be obtained from similar ground-based experiments. While the space-based processing environment does offer a low-g environment, it is not disturbance free. Results of experiments already conducted, particularly those in manned vehicles, show that spacecraft induced disturbances still limit what can be achieved in materials processing. The duration of actual micro-g level environments is shorter than desired and periods of milli-g activity levels are not uncommon. While small scale experiments can be configured to overcome some of the vehicle disturbance sources, larger scale processing devices and commercial activities will require alternative methods to reduce the influences of spacecraft vibrations. Applied Technology Associates, Inc., (ATA), in cooperation with NASA Lewis Research Center, is developing hardware to provide a sustained micro-g experiment environment. This work is being sponsored under a Small Business Innovation Research (SBIR) program, which is currently in the Phase 2 development stage. ATA's approach is based on an inertial actuator, which when used as part of a closed-loop stabilization system, rejects unwanted disturbances to the experiment package. A prototype of the actuator has been fabricated and used in a laboratory demonstration to prove the principle of operation. ATA's presentation emphasized the development and testing of the Digital Materials Processing Experiment (DAMPER) inertial actuator. Physical and performance characteristics of the device are presented. Technical issues, including further optimization of the actuator's performance and plans for additional laboratory experiments, are also covered.
Reversing clogging in Imhoff tanks by catalyzed hydrogen peroxide treatment

One of the most frequently encountered operational problems with Imhoff tanks is filter media clogging. Traditionally, the restoration procedure is to remove the clogged rock media and replace them with clean material. This is costly and may require the facility to close for a time. Recently, an innovative approach has been tested at lab- and full-scale. It consisted of aggressive oxidation and segregation of the clogged solids, using catalyzed hydrogen peroxide. The results indicate that, after treatment, clogging was substantially reduced. The outcomes of the lab- and full-scale studies are discussed in this paper.
Leaders of Color in Higher Education: Unrecognized Triumphs in Harsh Institutions

Part 1 Foreword Part 2 Acknowledgments Part 3 Introduction Part 4 Section I: Change, Difficulty, and Leadership Chapter 5 Chapter 1: Overcoming Much Adversity Chapter 6 Chapter 2: What Progress? Chapter 7 Chapter 3: Leadership: Metamorphosing Higher Education and Creating a Democratic Society Part 8 Section II: The Challenges and Dilemmas in Leading Chapter 9 Chapter 4: Pioneers As Educational Giants Chapter 10 Chapter 5: African American Leaders: Carving Out a Path from Hard Rock Chapter 11 Chapter 6: Latino Leaders: Conflicting Expectations, 'Si or No? Chapter 12 Chapter 7: Women of Color: Double the Problems, Twice Enriched Chapter 13 Chapter 8: Asian American Paradox: The "Model Minority" Still Begets Exclusion Chapter 14 Chapter 9: American Indians: Noble But Still Forgotten Part 15 Section III: Professional Growth and Keeping the Faith Chapter 16 Chapter 10: Lessons Learned and Consequences of Action Chapter 17 Chapter 11: The Rainbow Will Appear Part 18 References Part 19 About the Author Part 20 Index
The Implementation of project management : the professional's handbook

The need for project management planning for project management organizing for project management implementing the new project implementing government projects project planning project control tools of project management integrating cost and schedule automating the planning and control process the role of the project manager project risk management the project manager as a catalyst for innovation the training and development of the project manager completing the project and evaluating results project management in nontraditional areas the implementation of project management at AT implementation of project management within Atlanta Utilities a holistic approach to project planning and implementation C/CSCS and the failure of the A-12 programme project charter project master schedule work breakdown structure project organizational relationships project documents list project organization chart project network.
IKAROS and LEUKEMIA

Acute lymphoblastic leukemia (ALL) is characterized by an accumulation of immature lymphoid cells in the bone marrow and is the most common cancer type in children. It is an immunophenotypically, morphologically, clinically, and genetically heterogeneous disorder that comprises several distinct subtypes. Proper classification is important because determining the correct subtype plays a vital role for prognostication and treatment strategy. During the last decades, the use of polychemotherapy and implementation of risk stratification based on the presence of certain acquired genetic changes in pediatric B-cell precursor (BCP) ALL have increased the overall survival rates substantially; they are now approaching 90%. This notwithstanding, 20% of patients still relapse and only half of these survive. A considerable proportion of all relapses lacks the high risk-stratifying genetic changes included in most current ALL treatment protocols. Hence, it is important to identify novel genetic features associated with treatment failure to ensure proper therapy intensity and to detect genes and pathways that in the future can be targeted by specific drugs. To identify relapse-associated genetic aberrations in pediatric BCP ALL, single nucleotide polymorphism array analyses were performed on uniformly treated patients accrued between 1992 and 2011 from the Lund and Linkoping University Hospitals (Article I). In the 191 successfully analyzed cases, deletions of IKZF1 (∆IKZF1) and SPRED1 were shown to be associated with a poor prognosis, with ∆IKZF1 being an independent risk factor for relapse. To ascertain whether ∆IKZF1 is an independent risk factor also in the context of minimal residual disease (MRD) findings, an extended cohort including all 334 Swedish pediatric BCP ALL cases with known IKZF1 status was investigated (Article II). That study confirmed that ∆IKZF1 confers a poor prognosis, revealed that such deletions are particularly common in cases with uninformative cytogenetics, and showed that the prognostic impact of ∆IKZF1 is independent of MRD stratification. However, coexisting genetic changes may play a role in modifying the pathogenetic and/or clinical impact of ∆IKZF1. Therefore, ∆IKZF1-positive cases were investigated further in Article III in order to identify additional, recurrent changes. Furthermore, targeted deep sequencing of all IKZF1 exons in 140 BCP ALL cases was performed, identifying sequence mutations (mutIKZF1) in 5.7%. Of the mutIKZF1-positive cases, one-fourth also harbored ∆IKZF1. In total, 35 cases with IKZF1 abnormalities (abnIKZF1), comprising ∆IKZF1 and/or mutIKZF1, could be analyzed with regard to other genetic anomalies. These analyses showed that CRLF2 rearrangements, caused by deletions of the pseudoautosomal region 1 (PAR1), and JAK2 mutations were significantly overrepresented in abnIKZF1-positive cases and that the presence of PAR1 deletions conferred a poor prognostic impact. Thus, in order to ascertain correctly the clinical ramifications of abnIKZF1 in pediatric BCP ALL, PAR1 deletions should possibly also be screened for.
Elimination of the zero-order term in off-axis digital holography by multiplexing light intensity ratio

In this paper, we present a method to eliminate the zero-order term in Fourier spectrum of off-axis digital holograms based on the linear change of the hologram. In a typical digital holographic setup, the three off-axis holograms are recorded by the object waves and the reference waves with the different intensity ratios. The three holograms were Fourier transformed, and then the spectra were linearly fitted to obtain two fitting coefficients. Then, the second and third holograms are multiplied by the corresponding coefficients, and the first hologram is subtracted from the hologram that is multiplied by the coefficient to obtain the hologram with the zero-order term eliminated. In the procedure of spectrum filtering, more high-frequency information can be intercepted in this spatial-frequency spectrum after removing the zero-order. The experiment results show that this method can obviously eliminate the zero-order term.