Miracle-dz/UniFAR-FTUs huggingface dataset:
Is Salvage of a Kidney Graft Possible as a Result of Hyperacute Rejection Immediately After Kidney Transplantation?

Hyperacute rejection is a rare complication of renal transplantation. It is mainly caused by preformed human leukocyte antigen antibodies and can lead to the loss of the transplanted kidney. Renal transplantation is a highly beneficial treatment for people with end-stage renal disease, greatly improving their quality of life. However, antibody-mediated rejection is a significant challenge for the long-term survival of transplanted kidneys. An 18-year-old male with nephrotic syndrome, who underwent bilateral renal nephrectomy due to severe proteinuria, received a living donor kidney. Pretransplant panel reactive antibodies were low. Cytotoxic T- and B-cell and non-HLA cross-match was negative. The graft became cyanotic and mottled within half an hour of transplantation. Allograft was quickly extracted, and a biopsy showed hyperacute rejection. The patient was treated with plasmapheresis, intravenous immunoglobulin, and eculizumab. The graft was successfully re-implanted after 18 hours. Further treatment included additional sessions of plasmapheresis, intravenous immunoglobulin, eculizumab, T-cell-depleting agent, and immunosuppressive therapy. Serum creatinine became stable, and renal biopsy after one month demonstrated intact parenchyma with no inflammation or fibrosis. This case highlights the critical importance of promptly removing the transplanted kidney and using aggressive immunotherapy to save renal allografts in cases of hyperacute rejection.
Assessing the Role of Digital Marketing in Navigating Challenges in the Indian Business Landscape

In the digital age, marketers face a dynamic landscape replete with both challenges and opportunities. They harness electronic media to effectively promote a wide array of goods and services. Among the chief challenges they encounter is the art of persuasion and the strategic cultivation of prospective customers. Addressing this challenge can be achieved by fostering customer engagement and conversation through the utilization of digital media. This study underscores the pivotal significance of digital marketing for both marketers and customers, seeking to understand the superiority of digital marketing over traditional media and elucidating the key differentiators between the two. To conduct this research, the researcher employed a blend of primary and secondary data sources, employing structured, closed-ended questionnaires distributed to a sample of 105 respondents through Google Forms. The gathered data was meticulously analyzed using the SPSS statistical tool to unveil descriptive statistics such as frequency, mean, and standard deviation, as well as more complex analyses including cross-tabulations, regression analysis, and ANOVA. Complementing this primary data, secondary resources were tapped, including scholarly journals and articles, to provide a comprehensive review of the existing literature. This investigation will shed light on the primary determinants influencing the efficacy of digital marketing in the age of digitization, a period where nearly every marketer opts for digital channels to promote their brands.
The role of immune checkpoints in antitumor response: a potential antitumor immunotherapy

Immunotherapy aims to stimulate the immune system to inhibit tumor growth or prevent metastases. Tumor cells primarily employ altered expression of human leukocyte antigen (HLA) as a mechanism to avoid immune recognition and antitumor immune response. The antitumor immune response is primarily mediated by CD8+ cytotoxic T cells (CTLs) and natural killer (NK) cells, which plays a key role in the overall anti-tumor immune response. It is crucial to comprehend the molecular events occurring during the activation and subsequent regulation of these cell populations. The interaction between antigenic peptides presented on HLA-I molecules and the T-cell receptor (TCR) constitutes the initial signal required for T cell activation. Once activated, in physiologic circumstances, immune checkpoint expression by T cells suppress T cell effector functions when the antigen is removed, to ensures the maintenance of self-tolerance, immune homeostasis, and prevention of autoimmunity. However, in cancer, the overexpression of these molecules represents a common method through which tumor cells evade immune surveillance. Numerous therapeutic antibodies have been developed to inhibit immune checkpoints, demonstrating antitumor activity with fewer side effects compared to traditional chemotherapy. Nevertheless, it’s worth noting that many immune checkpoint expressions occur after T cell activation and consequently, altered HLA expression on tumor cells could diminish the clinical efficacy of these antibodies. This review provides an in-depth exploration of immune checkpoint molecules, their corresponding blocking antibodies, and their clinical applications.
The role of cancer nurses in cancer-related pain management in Europe

Cancer pain is a common symptom in patients with cancer and can largely affect their quality of life. Pain management is important to minimize the impact of pain on daily activities. Cancer nurses are significantly involved in all steps of pain management and contribute to the success of therapy through their knowledge and expertise. While they generally play an important role in the screening, assessment, diagnosis, treatment and follow-up of patients and their (pain) symptoms, this varies from country to country in Europe. An important aspect is their role in educating patients and their families about what pain is, what impact it can have, how it can be treated pharmacologically or non-pharmacologically and what effects or problems can occur during treatment. While there is a great discrepancy between education and training opportunities for cancer nurses in different European countries, there is a continued need for education and training in pain management. Cancer is increasingly becoming a chronic disease, and the management of pain in cancer survivors will be crucial to maintain an adequate quality of life. With this, the crucial role of cancer nurses is becoming even more important.
Demographic characteristics and prognosis of HHV8-positive diffuse large B-cell lymphoma, not otherwise specified: Insights from a population-based study with a 10-year follow-up

HHV8-positive diffuse large B-cell lymphoma, not otherwise specified (HDN) is a subtype of lymphoma that usually arises in association with HHV8-positive multicentric Castleman disease. However, the epidemiology, treatment patterns, and survival outcomes of HDN are poorly understood. A retrospective analysis was performed for 67 patients with HDN diagnosed from 2011 to 2020 using the SEER database. The demographic characteristics, treatment modalities, and survival outcomes of HDN patients were evaluated. Kaplan–Meier analysis and Cox regression analysis were employed to identify prognostic factors for overall survival (OS) and disease-specific survival (DSS). The age-adjusted incidence rate of HDN was 0.010 per 100,000 person-years. The median age at diagnosis was 51.8 years with male predominance. The primary site distribution was mainly nodal (79.1%), while the extranodal sites were rarely involved (20.9%). The majority of patients were white (65.7%). Only 3.0% of patients received radiotherapy, while 55.2% received chemotherapy. The 1-year, 3-year, and 5-year OS was 67.4%, 65.6%, 58.4%, and 56.3%, respectively, and the corresponding DSS was 73.1%, 73.1%, and 67.8%, respectively. The diagnosis year group of 2016–2020 had a significantly worse OS than the diagnosis year group of 2011–2015 (P = .040), but not for DSS (P = .074). No significant survival improvement was observed in patients underwent chemotherapy. Age and marital status were independent prognostic factors for OS, and age was an independent prognostic factor for DSS. In conclusion, HDN is a rare and aggressive disease, our study provides a comprehensive overview of the epidemiology, treatment patterns and survival outcomes of HDN patients for the first time. We revealed that older age and marital status of single were associated with worse survival of HDN, while chemotherapy was not associated with improved survival outcomes in HDN patients.
The spatiotemporal pattern of surface ozone and its impact on agricultural productivity in China

Abstract The slowing of agricultural productivity growth globally over the past two decades has brought a new urgency to detect its drivers and potential solutions. We show that air pollution, particularly surface ozone (O3), is strongly associated with declining agricultural total factor productivity (TFP) in China. We employ machine learning algorithms to generate estimates of high-resolution surface O3 concentrations from 2002 to 2019. Results indicate that China's O3 pollution has intensified over this 18-year period. We coupled these O3 estimates with a statistical model to show that rising O3 pollution during nonwinter seasons has reduced agricultural TFP by 18% over the 2002–2015 period. Agricultural TFP is projected to increase by 60% if surface O3 concentrations were reduced to meet the WHO air quality standards. This productivity gain has the potential to counter expected productivity losses from 2°C warming.
Post-Traumatic Dissection of the Right Common Carotid Artery: A Case Report

Arterial injuries in neck trauma often result in serious consequences that can compromise the patient's vital prognosis. Artery dissection injuries are not uncommon in traumatic events in this region. The diagnosis is based on a combination of clinical signs and confirmed by imaging. The management of neck arterial injuries is now based on algorithms based on the patient's clinical presentation at admission. We report the case of a patient who suffered a penetrating neck injury and whose imaging confirmed a dissection of the common carotid artery with occlusion of the internal carotid artery and for whom surgery was indicated based on clinical and radiologic findings.
Dynamical downscaling simulation and future projection of summer rainfall in Taiwan: Contributions from different types of rain events

Summer rainfall in Taiwan is composed of four types of rain events: tropical cyclone (TC), frontal convection (FC), diurnal convection (DC), and other southerly convection (SC) that propagates from the nearby ocean. In this study, we accessed the present‐day simulation (1979–2003) and future projection (2075–2099, the Representative Concentration Pathway 8.5 scenario) of rainfall in Taiwan by using the regional Weather Research and Forecasting model driven by the global High Resolution Atmospheric Model. The results indicated that the dynamical downscaling process adds value to the present‐day simulation of summer rainfall in Taiwan and the contribution of different types of rain events. It was found that summer rainfall in Taiwan will increase in a warmer future and that this change was mainly due to an increase in SC rainfall (i.e., light rainfall event). The following trends in Taiwan rainfall were also predicted in a warmer future: (1) SC rainy days will increase because the intensified monsoonal flow facilitates the propagation of more SC toward Taiwan, (2) TC rainy days will decrease as the Western North Pacific subtropical high extends southwestward and prevents TC systems from passing over Taiwan, (3) DC rainy days will decrease in response to the increased local thermal stability, and (4) FC rainy days will show no significant changes. Moreover, all types of rainfall are projected to become more intense in the future due to the increased moisture supply in a warmer climate. These findings highlight how the rainfall characteristics in East Asia may change in response to climate change.
Bronchial reactivity and asthma at school age after early-life metapneumovirus infection

Background The association between early-life lower respiratory tract infection (LRTI) and asthma is well established. Knowledge about bronchial hyperresponsiveness (BHR) and asthma after metapneumovirus (MPV) LRTI is scarce. The aim of this study was to assess BHR and current asthma in school-aged children after hospital admission for early-life LRTI with MPV, and to compare with more well-known viruses, rhinovirus (RV) and respiratory syncytial virus (RSV), and with controls. Methods A cohort consisting of children admitted for LRTI and controls was followed-up at school age with a clinical research assessment and lung function tests, including a methacholine provocation test. Current asthma was defined based on objective variable airway obstruction and clinical symptoms. BHR and asthma were compared according to viral groups. Results 135 children (median age 9.3 years) were included (16 MPV, 34 RV, 51 RSV, 13 mixed infections and 21 controls). Compared with controls there was increased BHR after MPV and RV LRTI (provocative dose causing a 20% fall in forced expiratory volume in 1 s and dose–response slope; p<0.05). Using Kaplan–Meier statistics, BHR was increased for MPV compared with both controls and RSV (p=0.02 and p=0.01). The proportion of children with current asthma at follow-up was higher in the LRTI children compared with the controls (46% versus 24%; p=0.06). Among children who had undergone MPV and RV infection, 50% fulfilled the asthma criteria compared with 43% in the RSV group (p=0.37). Conclusion We found increased BHR and a high prevalence of asthma in school-aged children after early-life MPV infection, and findings were similar to RV, and less to RSV, compared with controls.
The relationship between burden and caregiver’s sleep disturbances in dementia: a systematic review

ABSTRACT Caregivers of people living with dementia (PLwD) have a high burden degree that leads to health issues, including sleep. Objective: This study aimed to analyze the impacts of the caregiving burden on caregiver’s sleep disturbances. Methods: This systematic review involved a qualitative analysis of publications on Web of Science and Pubmed/Medline databases published between February 2018 and August 2022. Results: A total of 27 studies were identified and analyzed. Caregiver’s sleep presents impairments in sleep latency, sleep fragmentation, sleep duration, subjective sleep quality, daytime dysfunction, and insomnia. Caregiver’s distress and depressive symptoms have a dual relationship with sleep problems. Conclusion: Sleep disturbances presented by caregivers are correlated with higher burden levels and lead to more vulnerability to psychiatric symptoms and health issues.
AGREGANDO VALOR A LAS FRUTAS DEL CERRADO BRASILEÑO: ENCAPSULACIÓN DE ACEITE DE PEQUI A TRAVÉS DEL SECADO POR ATOMIZACIÓN

The pequi oil is a nutritionally rich product and the purpose of the encapsulation using spray drying is extending it shelf life and making it easier to handle. The aim of this work was to characterize physically, chemically and morphologically the pequi oil microparticles produced by spray drying. It was used an emulsion 10 % (w/w) and a wall system mixture of 25/50/25 consisted by gum arabic, modified starch and maltodextrin, respectively. The drying conditions were: 180 and 105 °C as inlet and outlet air temperature, respectively, and a double peak fluid atomization system with feed rate at 0.96 L.h-1. The results of the process show a 36 % of microencapsulation efficiency, spherical particles, smooth, and invaginations, high polydispersity as a function of size and a tendency of agglomerations of the particles. The product shows a great solubility (approximately 79.38%), a low wettability (approximately 954s), and it luminosity is close to the white and tends to red and yellow.
Population structure and genetic diversity in Eucalyptus pellita based on SNP markers

Eucalyptus pellita has the characteristics of rapid growth and high resistance. However, there is little research on molecular breeding of E. pellita, which is essential to shortening breeding life and selecting quality varieties. Therefore, a crucial step before selective breeding can be carried out to increase the wood quality of E. pellita is identifying genetic diversity and population structure using single nucleotide polymorphism (SNP) markers. In this study, the genetic diversity of 1st generation 196 E. pellita families from 23 geographically defined was assessed using 1,677,732 SNP markers identified by whole genome resequencing. SNP annotation showed that the ratio of non-synonymous to synonymous coding mutations was 0.83. Principal component analysis (PCA), phylogenetic tree, and population structure analysis permitted the families to be categorized into three groups, one of which (G2) contains most of the Indonesian (IDN) and Papua New Guinea (PNG) families. Genetic relationship analysis showed that IDN was closely related to PNG. Genetic diversity analysis showed that He, PIC, I, and H mean values were 0.2502, 0.2027, 0.3815, and 0.2680, respectively. PCA analysis classified various provenances in QLD into two categories (G1 and G3). The genetic diversity of G3 was higher than that of G2. The results of genetic differentiation (Fst) showed that PNG region was divided into two groups (PNG1 and PNG2), the Fst (0.172) between QLD and PNG2 region was higher than QLD and PNG1, and the Fst (0.024) between IDN and PNG1 is smaller than IDN and PNG2. A Mantel test revealed a positive correlation between the genetic and geographic distance of E. pellita. This study has a certain reference value for genetic identification, germplasm preservation, and breeding of E. pellita. Also, it provides a basis for subsequent association analysis to explore excellent alleles and introduction.
A micro-foundation of a simple financial model with finite-time singularity bubble and its agent-based simulation

This paper proposes a mathematical model of financial security prices in continuous time with bubbles in which prices may diverge and crash in finite time. Just before the bubbles burst, prices increase super-exponentially. In addition, a discrete-time excess demand model is proposed to provide a micro-foundation for the continuous-time model. The derived discrete-time security price model has the same characteristics as the continuous-time price model and expresses the finite-time singularity. Furthermore, based on the excess demand model, an agent-based simulation is performed to check the price behavior. As expected, we can confirm that prices can diverge in finite time and increase super-exponentially.
Om kommersialiseringsprocessen för företag inom miljöteknik och cleantech

Syftet med denna artikel ar att ge ett inspel i fragan om miljoteknikforetag har en langre kommersialiseringsprocess (fran ide till ett livskraftigt tillvaxtforetag) an andra tillvaxtforetag. Det ar en viktig fraga for alla intressenter till miljotekniksegmentet, fran entreprenorer som utvecklar miljoteknik och finansiarer som finansierar dessa foretags utveckling till forskare som vill skapa forstaelse till policymakers som vill behover informationen for att kunna justera och anpassa de politiska instrument som behovs for att stimulera detta viktiga segment. Sammanfattningsvis saga att kommersialiseringsprocessen for miljoteknik generellt kan sagas vara langre an for andra tillvaxtforetag pa grund av generellt sett fler risker och barriarer for dessa foretag an andra tillvaxtforetag, men att detta samtidigt paverkas starkt av vilket segment man arbetar inom. De miljotekniksegment som framforallt har langa processer ar segment med hog kapitalintensivitet i kombination med hog teknologisk risk.
Market Integration of Small-Scale Farms: Exploring the Bambara Groundnut Markets in Nigeria

The extent of uncertainty caused by price inefficiency and instability with reference to Bambara groundnut has made the subsector a dicey one. Markets that are not integrated may convey inaccurate price signals that might distort producers’ marketing decisions and contribute to inefficient product movement. The study analyzed the market integration of Bambara groundnut in South-east, Nigeria. The study population comprised all Bambara groundnut marketers in South-east, Nigeria. Out of the five states in South-east, Nigeria, two States will be purposively selected as the study area to establish the movement of prices between the two states to establish a fair comparison of prices between the producing zone and consumption zone. The choice of the two states was based on the predominance of Bambara groundnut marketers. A two-stage sampling technique was adopted in selecting 221 respondents that were interviewed for the study. Data for this study was poised from primary sources using a well-structured questionnaire, oral interviews and direct observations of Bambara groundnut marketers and was analyzed using descriptive and inferential statistics. - The results of the VECM showed that Enugu urban retail prices had a short-run influence of -0.057 although not signicant and a long-run significant influence of -0.2391 on Abia urban retail prices. The results of the VECM estimates for both short-run and long-run relationships indicated that the Enugu rural price of Bambara groundnut had short-run influences of -0.034023 and 0.0032032 with a long-run influence of -0.203230 on Abia rural price. The study recommended that to improve pricing effectiveness and market integration, it is necessary to encourage Bambara groundnut market price information in South-east Nigeria. The flow of information regarding Bambara groundnut prices, demand, and supply will improve both market integration and pricing effacing. The government should create regulations for information services. How to Cite: Agbo Josephine Nkechi, Okpukpara Benjamin C. , Ude Kingsley David, Udemba Klinsmann Uche. , 2023. "Market Integration of Small-Scale Farms: Exploring the Bambara Groundnut Markets in Nigeria. " Journal of Agriculture and Crops, vol. 10, pp. 11-19.
Impact of Snail and Mussel Consumption on Hydroxyproline Levels and Clinical Parameters in Arthritis Patients

: This study evaluates the serum hydroxyproline levels in arthritis patients compared to individuals who consume snails and mussels. It involved 100 participants, with 50 having arthritis (Group A) and 50 non-arthritis (Group B) individuals consuming snails and mussels. The biomarker especially hydroxyproline (HP) and clinical parameters viz. haemoglobin (Hb), total cholesterol (TC) and random blood glucose (RBG) were also estimated for group A and group B separately. The biomarker HP (pg/ml), TC and RBG (mg/dl) were significantly (P<0.0001) decreased in group B (1.1 ± 0.2, 149.4 ± 18.3 and 117.5 ± 8.4) when compared to group A (2.3 ± 0.4, 281.3 ± 58.6 and 188.0 ± 54.0). The Hb (%) was significantly (P<0.0001) increased in group B (12.2 ± 0.6) when compared to group A (11.5 ± 1.0). Key findings include significant differences in hydroxyproline levels and other clinical parameters between the two groups, suggesting potential benefits of these natural products in managing arthritis.