Miracle-dz/UniFAR-FTUs huggingface dataset:
Norepinephrine Release in the Spleen and Cells and B Cells In Vivo Increases Th2 + Activation of Antigen-Specific CD4

The neurotransmitter norepinephrine (NE) binds to the b 2 -adrenergic receptor ( b 2 AR) expressed on various immune cells to inﬂuence cell homing, proliferation, and function. Previous reports showed that NE stimulation of the B cell b 2 AR is necessary for the maintenance of an optimal primary and secondary Th2 cell-dependent Ab response in vivo. In the present study we investigated the mechanism by which activation of Ag-speciﬁc CD4 1 Th2 cells and B cells in vivo by a soluble protein Ag increases NE release in the spleen and bone marrow. Our model system used scid mice that were reconstituted with a clone of keyhole limpet hemocyanin-speciﬁc Th2 cells and trinitrophenyl-speciﬁc B cells. Following immunization, the rate of NE release in the spleen and bone marrow was determined using [ 3 H]NE turnover analysis. Immunization of reconstituted scid mice with a cognate Ag increased the rate of NE release in the spleen and bone marrow 18–25 h, but not 1–8 h, following immunization. In contrast, immunization of mice with a noncognate Ag had no effect on the rate of NE release at any time. The cognate Ag-induced increase in NE release was partially blocked by ganglionic blockade with chlorisondamine, suggesting a role for both pre- and postganglionic signals in regulating NE release. Thus, activation of Ag-speciﬁc Th2 cells and B cells in vivo by a soluble protein Ag increases the rate of NE release and turnover in the spleen and bone marrow 18–25 h after immunization. The Journal of Immunology, 2000, 165: 725–733.
Imaging of Magnetic Nanoparticles With Permeability Tomography

Magnetic nanoparticles are being increasingly used in numerous biomedical applications for diagnosis and therapy. During the course of these applications nanoparticle biodegradation and body clearance may occur. In this context, a portable, non-invasive, non-destructive and contactless imaging device can be relevant to trace the nanoparticle distribution before and after the medical procedure. We present a method for in vivo imaging the nanoparticles based on the magnetic induction technique, and we show how to properly tune it for magnetic permeability tomography, maximizing the permeability selectivity. A tomograph prototype was designed and built to demonstrate the feasibility of the proposed method. It includes data collection, signal processing and image reconstruction. Useful selectivity and resolution are achieved on phantoms and animals, proving that the device can be used to monitor the presence of magnetic nanoparticles without requiring any particular sample preparation. By this way, we show that magnetic permeability tomography may become a powerful technique to assist medical procedures.
with Structured Variational Cross-Graph Correspondence

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Verifying Online Health Rumors on Social Media: An Empirical Research Based on the Stimulus-Organism-Response Framework

: Many health rumors often appear on social media. The widespread spread of these rumors not only damages the reputation of social media platform, but also has a serious impact on individuals and society. Therefore, the research on the spread of health rumors has attracted academic attention. Based on the stimulus-organism-response framework, this study investigates the mediating role of people’s perception for verifying rumors, especially adding the variables of social consistency to explore the interacting effect on the intention to verify. An experiment was conducted to test the research model and the empirical result indicated the positive effect of perceived authenticity and perceived importance and the negative effect of perceived trust on verifying rumors. Besides, social consistency will moderate positively the effect of perceived trust and moderate negatively the effect of perceived importance. Compared to the wish rumors, the dread rumors will produce higher perceived importance and perceived trust. This study provides theoretical implications and practical guidance for online rumor research and practices.
Cumulative advantage in communication: implications of the

The knowledge deficit model proposes that more information increases public knowledge levels about a given topic, and thus improved related attitudes and practice. However, research critiques the varying and limited ability of the deficit model. Further, the deficit model can also produce an unintended cumulative advantage system: growing inequality between and within the knowledge-attitude-practice (KAP) gap of individuals and groups due to a wide variety of possible moderators. Over time, these effects can exacerbate gaps between individuals’ and groups’ levels of KAP. We discuss the negative effects of increasing inequality in sustainability KAP, and provide recommendations for future research.
Noncritical strings and W-algebras

Singularities of Spin(7) manifolds are considered in the worldsheet approach, and it is argued that the internal CFT describing a singular spin(7) has an enhanced ${\cal SW}({3\over 2},{3\over 2},2)$ algebra tensored with ${\cal N}=1$ linear dilaton CFT, much like singular Calabi-Yau CFTs have a ${\cal N}=2$ linear dilaton tensored with a suitable ${\cal N}=2$ SCFT. Upon adding fundamental strings, these vacua are related to $AdS_3$ vacua with ${\cal N}=1$ supersymmetry, completing the worldsheet classification of $AdS_3$ vacua with NS flux.
Four ways to get a grip on making robust decisions from workplace-based assessments

Synthesising the results of workplace-based assessments to inform robust decisions is seen as both important and difficult. Concerns about failing to fail the trainee not ready to proceed has drawn disproportionate attention to assessors. This paper proposes a model for a more systems-based view so that the value of the assessor’s judgement is incorporated while preserving the value and robustness of collective decision-making. Our experience has shown it can facilitate robust decisions on some of the more difficult areas, such as professionalism.
CT Angiography for the Prediction of Hemodynamic Signi ﬁ cance in Intermediate and Severe Lesions Head-to-Head With Quantitative Using as

OBJECTIVES The goal of this study was to compare the diagnostic performance of coronary computed tomography angiography (CTA) versus quantitative coronary angiography (QCA) for the detection of lesion-speci ﬁ c ischemia using fractional ﬂ ow reserve (FFR) as the gold standard. BACKGROUND Coronary CTA has emerged as a noninvasive method for accurate detection and exclusion of high-grade coronary stenoses. FFR is the gold standard for determining lesion-speci ﬁ c ischemia and has been shown to improve clinical outcomes when guiding revascularization. METHODS A total of 252 patients from 5 countries were prospectively enrolled (mean age 63 years; 71% male). Patients underwent coronary CTA and invasive coronary angiography (ICA) with FFR in 407 lesions. Coronary CTA, QCA, and FFR were interpreted by independent core laboratories. Stenosis severity according to coronary CTA and QCA were graded as 0% to 29%, 30% to 49%, 50% to 69%, and 70% to 100%; stenosis $ 50% was considered anatomically obstructive. Lesion-speci ﬁ c ischemia was de ﬁ ned according to FFR # 0.8, whereas QCA and coronary CTA stenosis $ 50% were considered obstructive. Diagnostic accuracy and areas under the receiver-operating characteristics curve (AUC) for lesion-speci ﬁ c ischemia was assessed. RESULTS According to FFR, ischemia was present in 151 (37%) of 407 lesions. Diagnostic accuracy, sensitivity, speci-ﬁ city, positive predictive value, and negative predictive value were 69%, 79%, 63%, 55%, and 83% for coronary CTA;
International Journal of Agriculture and Environmental Research

This study on the restoration of land degraded by Soil Conservation and Soil Defense and Restoration (CES/DRS) technics was conducted in the rural community of Loga (Niger), at the village of Badoko. The study assessed some land restoration actions carried out to evaluate assess the level of their contributions to the resilience of agricultural land to climate change. The methodology used is based on socio-economic surveys, measurements of the technical standards of run off cashment structure (Bench) and the dendrometric survey of planted trees in naturally regenerated in Benches structures. The results showed (1) that communities are aware of the degradation of natural resources that has been restored using the benches appreciated and accepted by the populations; (2) that the money obtained by the beneficiaries has enabled households to eat well; (3) that the vegetation at the site was markedly improved by a high floristic richness (woody and herbaceous) with 0.63 bits of diversity and 0.59 bits of Piélou's equitability. This reflects an instability of the species in the environment whereas the Piélou equitability index follows the opposite trend; (4) that the species Acacia senegal and Bauhinia rufescens recorded the highest survival rates and the largest increases in diameters and heights; (5) that the high mortality of the species Ziziphus mauritiana is related to the eccentric position of this species which is found on the last rows of the Benches structures with a small supply of runoff water and the presence of the rodents which damaged the young Plants during their development. International Journal of Agriculture and Environmental Research
Infiltration into Antigen-Challenged Skin Perforin Directs Effector CD8 T Cell Neutrophil Expression of Fas Ligand and

Contact hypersensitivity (CHS) is a T cell response to hapten skin challenge of sensitized individuals proposed to be mediated by hapten-primed CD8 cytolytic T cells. Effector CD8 T cell recruitment into hapten challenge sites to elicit CHS requires prior CXCL1- and CXCL2-mediated neutrophil inﬁltration into the site. We investigated whether neutrophil activities directing hapten-primed CD8 T cell skin inﬁltration in response to 2,4-dinitro-1-ﬂuorobenzene (DNFB) required Fas ligand (FasL) and perforin expression. Although DNFB sensitization of gld /perforin 2 / 2 mice induced hapten-speciﬁc CD8 T cells producing IFN- g and IL-17, these T cells did not inﬁltrate the DNFB challenge site to elicit CHS but did inﬁltrate the challenge site and elicit CHS when transferred to hapten-challenged naive wild-type recipients. Hapten-primed wild-type CD8 T cells, however, did not elicit CHS when transferred to naive gld /perforin 2 / 2 recipients. Wild-type bone marrow neutrophils expressed FasL and perforin, and when transferred to sensitized gld /perforin 2 / 2 mice, they restored hapten-primed CD8 T cell inﬁltration into the challenge site and CHS. The FasL/perforin-mediated activity of wild-type neutrophils induced the expression of T cell chemoattractants, CCL1, CCL2, and CCL5, within the hapten-challenged skin. These results indicate FasL/perforin-independent functions of hapten-primed CD8 T cells in CHS and identify new CXCL9 accompanied the higher expression of IL-17 and IFN- g in the challenge site of sensitized gld /perforin 2 / 2 mice when compared with sensitized wild-type mice. These results suggest that FasL- and/or perforin-mediated activities of neutrophils have a direct and/or indirect role in regulating the intensity of the initial and ongoing inﬂammatory response in the vasculature of the hapten challenge site. We have previously observed higher levels of CXCL1 and CXCL2 when neutrophils are depleted at the time of hapten challenge. We interpreted this ﬁnding as further indication that neutrophil activity is not required for the initial localization of the hapten-primed CD8 T cell populations to the hapten-presenting endothelial cells in the challenge as well as the digestion of the CXCL1 and CXCL2 by the inﬁltrating neutrophils as has been observed in other inﬂammatory models (49). the results of a novel function for to induce the chemoattractants directing Ag-primed T cells through the vascular barrier into parenchymal tissues to mediate an immune response. These results suggest the possible strategyof using isolated neutrophil transfer to promote Ag-primed T cell inﬁltration into sites of peripheral tissue inﬂammation to potentiate effective immune responses to tumors and Differences in the effector of Ag-primed T cell may dictate the requirements for prior neutrophil inﬁltration effective T
TAVR and Stroke Prevention

non-bleeding-related deaths were similar between shorter and longer DAPT duration. Our study therefore suggests for the first time a mechanistic association between bleeding, mortality, and DAPT duration. We agree with the authors that certain patient types (including those with acute myocardial infarction) may have greater absolute benefit in terms of suppression of stent-related and non-stentrelated ischemic complications with prolonged DAPT. The challenge then arises in identifying those patients in whom the potential benefits from prolonged DAPT will outweigh its potential harm. This equation is more complex than just choosing a single factor, such as clinical presentation. Numerous clinical and anatomic factors must be considered (4). In this regard the DAPT score may be a useful starting point (5), although this instrument neglects several important predictors of bleeding that were not available from the DAPT trial, including prior bleeding, baseline anemia, and chronic oral anticoagulation use. Finally, even in patients presenting with myocardial infarction and other conditions at high risk for ischemia, prolonged DAPT has not been shown to reduce mortality, a finding that further emphasizes the offsetting risks of bleeding.
A cross-sectional feasibility study of nutrient intake patterns in people with compared

Diet could have implications for disease progression and management in people with 22 Parkinson’s (PwP). However, the knowledge of diet intake patterns in PwP is limited. We set out to assess the feasibility of collecting diet data in PwP to determine food and nutrient intake, in order to compare to national nutrition guidelines and thus understand the 27 habits in this population. through criteria included a Completeness of was and was appropriate for each including We observed high levels of engagement from PwP and found that assessing food and nutrient patterns in PwP was feasible. Importantly, the diet was generally healthy overall, yet there were specific nutrients that may affect medication metabolism in PwP which were found to be high. Therefore further research into this emerging and important area is warranted. This study provides a current snapshot of comprehensive assessment of the food and nutrient patterns in PwP compared to nutritional guidelines. Research into the diet patterns in this group was shown to be feasible and well received. This study is the first to show that PwP generally have healthy diets compared to the UK guidelines, yet may be unhealthy on some critical dietary components for their condition. The development of clear specific dietary guidance and pathways for implementation may be required to maintain the health of PwP and to help them understand the importance of optimal dietary manipulation for their condition.
Urban park characteristics, genetic variation, and historical demography of white-footed mouse ( ) populations in

Severe fragmentation is a typical fate of native remnant habitats in cities, and urban wildlife with 20! limited dispersal ability are predicted to lose genetic variation in isolated urban patches. 21! However, little information exists on the characteristics of urban green spaces required to 22! conserve genetic variation. In this study, we examine whether isolation in New York City 23! (NYC) parks results in genetic bottlenecks in white-footed mice ( Peromyscus leucopus ), and test 24! the hypotheses that park size and time since isolation are associated with genetic variability using 25! nonlinear regression and information-theoretic model selection. White-footed mice have 26! previously been documented to exhibit male-biased dispersal, which may create disparities in 27! genetic variation between males and females in urban parks. We use genotypes of 18 neutral 28! microsatellite data and four different statistical tests to assess this prediction. Given that sex- 29! biased dispersal may create disparities between population genetic patterns inferred from bi- vs. 30! uni-parentally inherited markers, we also sequenced a 324 bp segment of the mitochondrial D- 31! loop for independent inferences of historical demography in urban P. leucopus . We report that 32! isolation in urban parks does not necessarily result in genetic bottlenecks; only three out of 14 33! populations in NYC parks exhibited a signature of a recent bottleneck at 18 neutral microsatellite 34! loci. Mouse populations in larger urban parks, or parks that have been isolated for shorter 35! periods of time, also do not generally contain greater genetic variation than populations in 36! smaller parks. These results suggest that even small networks of green spaces may be sufficient 37! to maintain the evolutionary potential of native species with certain characteristics. We also 38! found that isolation in urban parks results in weak to nonexistent sex-biased dispersal in a 39! species known to exhibit male-biased dispersal in less fragmented environments. In contrast to 40! nuclear loci, mitochondrial D-loop haplotypes exhibited a mutational pattern of demographic on a thermocycler for 30 cycles of
The Impact of Animation Technology in Mechanical Engineering Education

Mechanical engineering is one important area of engineering. Students of mechanical engineering require practice and live experiments on complex machines and tools. Unfortunately, certain machines are hard to purchase or to make available for learning purposes. Such situations require technology and multimedia to support its delivery of information. The final results showed that the majority of level four mechanical engineering students in the International Islamic University Malaysia agreed and preferred using animation technology in their studies. Practically, the author designed a short animated presentation of a mechanical engine that is provided in the questionnaire for the students to evaluate. Following this, the collected data is analyzed using the factor analysis method. In conclusion, it is believed that the animated presentation of each individual part of a machine, no matter how complex it may be, will enhance students learning capabilities compared to traditional methods of learning.
Expanding phenotype of FAM111B ‐related disease focusing on liver involvement: Literature review, report of a case with end‐stage liver disease and proposal for a new acronym

POIKiloderma, tendon contractures, myopathy, pulmonary fibrosis is a congenital multisystem disorder due to FAM111B dominant variants. We present a literature review focusing on the frequency and the impact of hepatic involvement and a case report of a patient with severe end‐stage liver disease. Whole exome sequencing (WES) was conducted on the proband and his parents. A de novo FAM111B: c.1879A > G; (p.Arg627Gly) variant was identified. Hepatic involvement is present in 11 out of the 30 patients described in the literature, with different levels of dysfunction ranging from mild transaminitis to liver fibrosis found in three different cases by liver biopsies. Liver involvement seems to be a significant cause of morbidity. We propose to modify the previous acronym in POIK‐TMPL: including POIKiloderma, tendon contractures, myopathy, pulmonary fibrosis/pancreas insufficiency and cancer, liver involvement/lymphedema. Moreover, we suggest screening patients with FAM111B variants for liver involvement from the first month of life and continue with an appropriate follow‐up. Further studies are needed to better understand this frequent complication.
The value of concurrent endoscopic ultrasound‐guided fine needle aspirates and needle core biopsies in the diagnosis of pancreatic neoplasms

Endoscopic ultrasound (EUS) fine needle aspiration (FNA) is highly sensitive and specific in the detection and diagnosis of pancreatic neoplasms. EUS‐guided needle core biopsy has been used alone or as an adjunct to maximize diagnostic yield. This study compared the use of FNA versus needle core biopsy in the diagnosis of pancreatic neoplasms.
Ingested (Oral) Adrenocorticotropic Hormone Inhibits IL-17 in the Central Nervous System in the Mouse Model of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Experimental autoimmune encephalomyelitis (EAE) is an inflammatory autoimmune disease of the CNS that resembles multiple sclerosis and provides a useful animal model for the evaluation of mechanisms of action for potential immunomodulatory therapies. We have previously shown that oral adrenocorticotropic hormone (ACTH) decreased IL-17 in the gut lamina propria and the spleen and increased CD4+ Foxp3+ T regulatory cells and IL-10 in the spleen during EAE in the C57BL/6 mouse. However, we did not investigate the specific cellular alterations of proinflammatory and anti-inflammatory factors in the CNS. The aim was to determine if oral ACTH would have a similar clinical effect on inflammatory cytokines in the gut and define specific cellular effects in the CNS in an alternative strain of mice. SJL/J mice were immunized with proteolipid protein peptide 138–151 and gavaged with scrambled ACTH (scrambled α-melanocyte-stimulating hormone) or ACTH 1–39 during ongoing disease. Ingested (oral) ACTH attenuated ongoing clinical EAE disease, decreased IL-6 production, and increased T regulatory cells in the lamina propria and decreased CD4+ and γδ IL-17 production in the CNS. Ingested ACTH attenuated EAE clinical disease by decreasing IL-6 in the gut-associated lymphoid tissue and decreasing IL-17 in the CNS.