Miracle-dz/UniFAR-FTUs huggingface dataset:
Prediction of triptolide targets in colorectal cancer using network pharmacology and molecular docking

Network pharmacology is an approach that uses bioinformatics to predict and identify multiple drug targets and interactions in disease. Here, we applied network pharmacology to investigate the potential mechanisms of action of triptolide, an active component in the traditional Chinese medicine Tripterygium wilfordii Hook F, in colorectal cancer (CRC). We first searched public databases for genes and proteins known to be associated with CRC, as well as those predicted to be targets of triptolide, and then used Ingenuity Pathway Analysis (IPA) to identify enriched gene pathways and networks. Networks and pathways that overlapped between CRC-associated proteins and triptolide target proteins were then used to predict candidate protein targets of triptolide in CRC. The following proteins were found to be expressed in both CRC-associated networks and triptolide target networks: JUN, FOS, CASP3, BCL2, IFNG, and VEGFA. Docking studies suggested that triptolide can fit in the binding pocket of the four top candidate triptolide target proteins (CASP3, BCL2, VEGFA and IFNG). The overlapping pathways were activation of neuroinflammation signaling, glucocorticoid receptor signaling, T helper (Th) cell differentiation, Th1/Th2 activation, and colorectal cancer metastasis signaling. These results show that network pharmacology can be used to generate hypotheses about how triptolide exerts therapeutic effects in CRC. Network pharmacology may be a useful method for characterizing multi-target drugs in complex diseases.
Advanced treatment of paper-making wastewater using catalytic ozonation with waste rice straw-derived activated carbon-supported manganese oxides as a novel and efficient catalyst

Waste rice straw was converted into activated carbon-supported manganese oxides (MnOx/RSAC) that were fi rst used as a catalyst to improve the performance of ozonation of real paper-making wastewater. The results indicated that catalytic ozonation with the prepared catalyst exhibited a highly effi cient performance in advanced treatment of paper-making wastewater, and the corresponding color and COD removal effi ciencies were 58.5 and 77.5%, respectively. And the treated wastewater was more biodegradable and less toxic than that in ozone alone. Based on signifi cant inhibition of the radical scavenger and fl uorescence test in the catalytic ozonation process, we deduced that the enhancement of catalytic activity was responsible for MnOx/RSAC catalyzing ozone to generate more hydroxyl radicals and the possible reaction pathway was proposed. Thus, MnOx/RSAC catalyzing ozonation could serve as a stable, effi cient, and economical process with a potential engineering application for treated refractory wastewater, and the results offered new insights for sustainable use of waste rice straw.
Growth of Highly Crystalline and Large Scale Monolayer MoS2 by CVD: The Role of substrate Position

Monolayer (ML) molybdenum disulphide (MoS2) is of great interest for the scientific community due to its attractive electronic, optoelectronic and mechanical properties. Synthesis of high quality and large size ML MoS2 at low cost is still a challenge. Here, the growth of large area (≈5 × 1 mm2) ML MoS2 on SiO2/Si substrate via chemical vapor deposition (CVD) method is reported. It is shown by changing the substrate position w.r. t. MoO3 precursor, that the quality and size of the ML MoS2 can be drastically tuned. Raman spectroscopy and transmission electron microscopy are performed in order to ascertain the growth and high crystallinity of MoS2. Uniformity of MoS2 layer is adjudged by Raman mapping while atomic force microscopy is performed to determine the thickness of the layer. Kelvin probe force microscopy is performed on ML MoS2 to draw the band line up of the material.
CONTEMPORARY CHALLENGES TO THE DEVELOPMENT OF CITIES – THE EXPERIENCE OF POLAND AND UKRAINE

The article reveals the key problems of the development of cities facing modern challenges. The demographic, ecological and financial problems connected with the functioning of modern cities are determined. The range of issues that need to be solved with the purpose of effective development of cities is clarified. The principles of the functioning of the smart city system due to the continuous processing and updating of data coming from various information channels are revealed. The key approaches to understand­ ing the main components of the smart city are presented. The perspective of the idea of a smart city was substantiated and comparison of the current state of the smart city concept in Poland and Ukraine was made. The article uses literature studies to define the ideas and challenges of a smart city as well as case studies to present solutions in this field used in Warsaw and Kiev. It turns out that these cities, though they have a great development potential, are based on individual innovations rather than on a coherent strategy. It is particularly visible in Warsaw, where the problem is the lack of integration of activities that are undertaken in a selective manner. A positive fact is the increasing involvement of ICT in the city management process. The added value is the systematic improvement of the quality of public services and the increase in social participation in the process of making public decisions. The latter aspect makes it possible to integrate local society and build trust in public institutions.
FTIR, XRD and SEM Analysis of Microcrystalline Cellulose (MCC) Fibers from Corncorbs in Alkaline Treatment

In this paper, we report the isolation method of cellulose, alpha cellulose and microcrystalline cellulose from corncorbs waste in alkaline treatment NaOH 4%,6%,8%,10%,12%,14% and 17% solution. Dewaxing, dehemiselulosa, delignifikasi and bleaching is the stage of cellulose isolation. The MCC particles were extracted by acid hydrolisis with 0.1N HCl. The 4% NaOH concentration provides the highest α-cellulose content (60%) with total yield MCC of 84.53%. SEM, FT-IR and X-ray diffraction analyzes are used to determine of the MCC. FTIR spectra showed that each MCC had -OH group, stretching of C-O on cellulose fiber I and cellulose II. C-0 bonds shows a change in rotation of glucose residue around the glycosidic bond into Cellulose II. SEM analysis showed that the concentration of 6% NaOH has a morphological structure such as cellulose standard. The 8% NaOH concentration yields a CrI value of 98%.
InverseWorkflows for Supporting Agile Business Process Management

: Agile processes allow organizations to ﬂexibly react on new and unforeseen situations. However, modiﬁcations must adhere to the standards and quality requirements given by an organization. In this paper, the concept of inverse workﬂows is presented to support organizations in meeting this goal. Inverse workﬂows provide a means to explicitly express unwanted procedures and work situations. In conjunction with an automated system to detect inverse workﬂow enactment, organizations can prevent undesired developments while they are emerging. This effectively allows controlling overall process quality while modeling or adapting business process to stakeholder demand.
A Contrast Adjusted Wavelet and Curvelet Transform Based Fusion of Breast Images

Restoration is one of the image processing techniques to restore the distorted image. The distorted image can be any type like blurred image, noise added either while storing or capturing of the images. the traditional restoration techniques are geometric correction, different types of filters to remove the noises. Generally, the restoration is applied to the single image to retrives its information. In this, the restoration process is applied in the application of image fusion of medical images. the reason to chose the image fusion process is to improve its entropy. The medical images used in this paper is the mammogram and MRI-breast image. In this, the image fusion is performed with the help of wavelet and curvelet transform. The curvelet transform is applied to the restored mammogram image with the help of contrast adjusted top-hat filter process. The wavelet transform is applied to the MRI image because it has more volume of data to acquire important details. The fused image is evaluated with the help of entropy, mean standard deviation and variance. The fused image has efficient value as compared to its original image but it is higher than the DTCWT-fused image. To verify the quality of the proposed method, the psnr is evaluated to determine the noise present in the image. From the evaluation, the noise is less and entropy is higher in the proposed method. Hence, the contrast adjusted wavelet curvelet fusion is the best restoration and fusion process in the breast images.
Effects of Sporidiobolus pararoseus Y16 on Postharvest Blue Mold Decay and the Defense Response of Apples

The efficacy of Sporidiobolus pararoseus Y16 in controlling postharvest blue mold caused by Penicillium expansum on apples and the defense response involved were evaluated. The results suggested that the decay incidence of blue mold of apples treated by S. pararoseus Y16 was significantly reduced compared with the control. In vitro testing indicated that germination of spores and germ tube length of P. expansum were markedly inhibited by S. pararoseus Y16. Meanwhile, polyphenol oxidase (PPO), peroxidase (POD), phenylalanine ammonia lyase (PAL), and catalase (CAT) activities and several pathogenesis-related (PR) gene expression levels (including PR3, PR4, PR5, and PR9) were determined. In apples, the activities of PPO, POD, CAT, and PAL were significantly induced by S. pararoseus Y16 treatment compared with the control fruits. The relative expression levels of PR3 and PR4 were significantly induced at 4 and 6 d, while PR5 was significantly induced at 4 and 6 d and PR9 was significantly induced at 4 d. Therefore, the reduction in apple fruit decay by S. pararoseus Y16 treatment could be related to the increased activities of related enzymes and proteins involved in the defense against pathogens, which suggest that S. pararoseus Y16 is a potential antagonistic yeast.
Research on Task Analysis Framework for Unconventional Sudden Decision-making Problems

In view of the structural uncertainty, suddenness and unpredictability of the current unconventional sudden decision-making problems, the analysis of the unconventional sudden emergency decision-making task analysis proposes a task analysis from task description to scenario construction and task analysis plan optimization process. In the task analysis, the joint extraction model is used to extract the task entities and the relationship between the task entities in the decision-making problem; the scenario construction is used to supplement the task description and constraint conditions; the cyclic neural network is used to simulate the thinking of the decision maker to complete the task analysis plan optimization. This analysis method adds hidden information such as the environment and constraints in the analysis to the analysis process, which is conducive to improving the suitability of the task analysis plan, and has application and promotion value in the research of task analysis framework for unconventional sudden decision problems.
Comparison between Relational and NoSQL Databases

Relational databases have not been the only solution for the applications that use them for years. New applications must deal with large volumes of complex, distributed data of different types, whose volume increases very rapidly. In these applications, relational databases are supplemented with several new generic data models referred to as NoSQL. In this article we shall present the main types and characteristics of NoSQL data models and we shall make, both a detailed and a synthetic, comparison between the relational model and the NoSQL data models.
Willingness to communicate in English among non-English major Malaysian Undergraduates

Current policies to second language teaching (L2) put great emphasis on improving the communicative skills of the learners. Teachers, however, found that some learners avoid L2 communication despite their excellent proficiency level in the target language. The literature on learners' reticence highlights the considerable number of studies available on willingness to communicate (WTC). However, most of the studies were conducted in the contexts that bear little resemblance to a multicultural Malaysia. The present study aimed to explore how interlocutors and contexts contribute to the participants' WTC level. Data were gathered through face-to-face interviews (n = 14). The findings revealed that the participants' WTC fluctuate across interlocutors and contexts. The evidence from the current findings confirms the notion that WTC is a dynamic variable. However, the present data offers an alternative view concerning fluctuation across interlocutors. The paper concludes with pedagogical implications.
TiO2 THIN FILMS PREPARED BY SPIN COATING TECHNIQUE

The titania nanocoatings on indium tin oxide (ITO) were succefully obtained by the sol-gel process in an aqueous solution using the titanium diethanolamine complex as the precursor. FT-IR, UV – VIS, Raman spectroscopy and X-ray diffraction techniques have been used to investigate the chemical and physical changes during the sol-gel process and the characteristics of the TiO2 powder precursor. In this paper, we report on the preparation and characterization of TiO2 films prepared using the hydrolytic sol-gel process and deposited on ITO glass substrates by spin coating technique.
A Universal System for matK Gene Based Diagnostic Markers to Identify the Species in Cucurbitaceae

Designing and validation of universal primer combination for matK gene in Cucurbitaceae is described. Using the universal primers already reported, matK gene amplification was attempted in 24 Momordica and 4 Luffa accessions, which was successful at varying rates. Amplified markers were gel eluted, Sanger sequenced and the sequences along with the matK sequences from other Cucurbitaceae genera available at GenBank, were aligned to identify the conserved regions in the locus. Primer combination was designed for the conserved regions and this primer set was found successful for all the Momordica and Luffa accessions. Subsequently, the primer combination was shown successful for other genera such as Benincasa, Cucumis, Cucurbita, Citrullus, Coccinia, Trichosanthes and Lagenaria, suggesting it as a universal system for matK gene in Cucurbitaceae family.
Changing trends in aetiology and antibiotic resistance of symptomatic community acquired bacterial pneumonia in hospitalised adult patients -A South Indian study

Background: Community Acquired Pneumonia (CAP) of bacterial origin in adults is a leading cause of mortality and morbidity in developing countries. Etiological diagnosis plays a significant role in hospitalised patients for better treatment strategies. The present study analyses the trends in bacterial pathogens causing adult CAP in hospitalised patients along with comparison of their annual drug resistant profiles between years 2016 and 2017. Methodology: A total of 113 suspected cases of CAP in hospitalised patients from 2016 and 135 cases from year 2017 were included in the study. Respiratory specimens like sputum, broncho alveolar lavage and tracheal aspirates were collected aseptically in sterile containers and inoculated on appropriate culture media. Bacterial pathogens were identified by conventional methods and antimicrobial sensitivity testing was performed by Kirby-Bauer’s disc diffusion method. Results: Incidence of bacterial pathogens in hospitalised patients with CAP had increased from 60% in 2016 to 68% in 2017. Staphylococcus aureus (35%) and Klebsiella pneumoniae (27%) were common causative agents in 2016 while Klebsiella pneumoniae (36%) followed by Staphylococcus aureus (27%) were major pathogens in 2017. An upsurge in resistance pattern among Gram positive and Gram negative pathogens from 2016 to 2017 was observed. A rise in Methicillin Resistant Staphylococcus aureus and Extended Spectrum beta lactamase producing Escherichia coli and Klebsiella pneumoniae is of major concern. Conclusions: Periodical monitoring of local Etiological agents together with a study on resistant patterns would help in better management protocols in CAP. Keywords: Community Acquired Pneumonia; Klebsiella pneumonia; Staphylococcus aureus.
Water Loss During the Handwashing During COVID-19 Pandemic in Bangladesh

Handwashing is one of the vital public health measures to prevent COVID-19 pandemic from spread. However, water loss from excessive handwashing may put enormous pressure on the already overstretched groundwater resources and households’ economic well-being. Therefore, this study aimed to determine the water loss during handwashing amid the COVID-19 pandemic with an emphasis on the waste of groundwater from essential hygiene activities at domestic scale. Sociodemographic data were collected using a web-based survey tool among 1980 participants and an experiment was conducted among 126 voluntarily interested participants to estimate the amount of water wasted during handwashing. A total of 80% of the participants washed their hands regularly after returning home from outside. About 57.27% participants generally did not turn off their tap when washing their hands. A single participant, who keeps his tap on throughout the handwashing process, wasted approximately 1.7 L of water per handwash and 14.9 L of water per day. Handwashing when a tap is on, raised the water loss at 13-fold during this pandemic compared to the non-pandemic situation which cost extra 224.95 BDT (2.65$) per day for 1980 participants. A large number (57.27%) of people keep their faucet on during lathering hands with soap and scrubbing, thus wasting a considerable amount of water (1179% more compared to pre COVID-19 situation). The loss of water during handwashing is an alarming but less attentional issue. Behavioral change interventions are needed to aware people to shut off the faucet at periods when water is not being used.
Poor vs Non-Poor Households in Uruguay: Welfare Differences from Food Price Changes

Evidence suggests that household responses to price and income changes are significantly sensitive across income levels and rural-urban location. In this paper, we focus on poor households vs. non-poor households using two definitions of poverty, objective and subjective. We evaluate the differential responses of poor households vs. non-poor households to changes in food expenditures and prices and simulate the welfare losses from food price changes across poverty definitions. We use the QUAIDS model to estimate food elasticities with data from the National Expenditure and Household Income Survey, 20162017, from Uruguay. Expenditure elasticities at the food level reveal that bread and dairy products are a necessity-food category, regardless of the poverty status and across poverty definitions, while beverages are a luxury good. The demand sensitivity for the rest of the food categories differs by poverty status and poverty definitions. Uncompensated own-price elasticities indicate that when poverty is defined objectively, then changes in demand due to changes in price are greater for poor households (except for meat products). However, poor households, under the subjective definition, are more sensitive than non-poor households only to changes in beverage prices. Additionally, changes in household economic welfare due to price increases vary according to poverty status. On average, the percentage of total income needed to avoid a loss in economic welfare of poor households, defined by the objective method, is double that required by the non-poor households, for all price changes. However, differences are much smaller when using the subjective approach to measure poverty.
A dynamic adjustment account of word skipping in reading: Evidence from simulations and invisible boundary experiments

Prevalent models of eye movement control in reading of word-spaced orthographies assume a discrete control account to explain word skipping. Accordingly, word skipping results from advanced parafoveal word activation during preview, leading to the selection of word n+2 as a saccade target. Consequently, visual and linguistic content of the parafoveal word affect which word is selected as a saccade target. In contrast, according to dynamic adjustment view, saccade lengths in reading are affected by current and next word properties in a continuous manner. First, these predictions were confirmed via simulations for representative models of discrete and dynamic control. Then results of three gaze-contingent invisible boundary experiments studying the visuo-attentional mechanism of skipping are being reported. The results support the dynamic adjustment view by showing a unimodal landing position distribution across a candidate word for skipping and its subsequent word, and that the content of parafoveal word modulates the saccade length only slightly and in a continuous manner. In addition, the location of a visual anomaly within a word had no effect on saccade length, suggesting that parafoveal vision of next word is subject of attention enhancement early enough to affect saccade length computation.
Bioķīmisko un onkoloģisko marķieru diagnostiskā nozīme malignu pleiras eksudātu diferencēšanā no citas etioloģijas šķidruma pleiras dobumā. Promocijas darbs

Promocijas darbs izstrādāts Rīgas Stradiņa universitātes Ieksķīgo slimību katedrā. Aizstāvēsana: attālināti 2020. gada 29. maijā plkst. 15.00 Zoom platformā.
Overweight and Obesity as the Risk Factors for Leukemia in the Mediterranean Countries

It is known, that in countries with high and medium incomes, the proportion of people with overweight and obesity started to increase in the second half of the 20th century, as well as the incidence rate of Non-infectious Chronic Diseases (NCD). The study of risk factors for leukemia in the Mediterranean countries showed, that the incidence of leukemia for men was 2 times higher in countries with a higher Quality of Life (QOL); a higher percentage of men with overweight, obesity and hypercholesterolemia; a higher level of macronutrients, as on the whole as well as macronutrients of Animal Products (AP); a higher level of consumption of AP and Alcoholic Beverages (AB). Energy and proteins of animal products, beef and iron of animal origin, as well as hypercholesterolemia can determine more than 60% of the variability of the frequency of leukemia. At the same time, the level of total Energy does not significantly affect the incidence of leukemia. The ratio and origin of food and macronutrients have a greater effect on the incidence of leukemia than the absolute amounts of food and macronutrients in the nutritional structure.