Miracle-dz/UniFAR-FTUs huggingface dataset:
An efficient method for stochastic optimal control with joint chance constraints for nonlinear systems

Stochastic model predictive control hinges on the online solution of a stochastic optimal control problem. This paper presents a computationally efficient solution method for stochastic optimal control for nonlinear systems subject to (time‐varying) stochastic disturbances and (time‐invariant) probabilistic model uncertainty in initial conditions and parameters. To this end, new methods are presented for joint propagation of time‐varying and time‐invariant probabilistic uncertainty and the nonconservative approximation of joint chance constraint (JCC) on the system state. The proposed uncertainty propagation method relies on generalized polynomial chaos and conditional probability rules to obtain tractable expressions for the state mean and covariance matrix. A moment‐based surrogate is presented for JCC approximation to circumvent construction of the full probability distribution of the state or the use of integer variables as required when using the sample average approximation. The proposed solution method for stochastic optimal control is illustrated on a nonlinear semibatch reactor case study in the presence of probabilistic model uncertainty and stochastic disturbances. It is shown that the proposed solution method is significantly superior to a standard random sampling method for stochastic optimal control in terms of computational requirements. Furthermore, the moment‐based surrogate for the JCC is shown to be substantially less conservative than the widely used distributionally robust Cantelli‐Chebyshev inequality for chance constraint approximation.
PERAN INKUBATOR AGRIBISNIS DALAM PENGEMBANGAN EKOSISTEM KEWIRAUSAHAAN BERBASIS PERTANIAN

Penciptaan wirausaha baru yang handal diperlukan suatu ekosistem kewirausahaan. Konsep inkubator agribisnis telah diciba diimplementasikan oleh beberapa perguruan tinggi di Indonesia. Penelitian ini dilaksanakan dengan mengkaji konsep inkubasi agribisnis dalam upaya pengembangan ekosistem kewirausahaan berbasis pertanian pada Fakultas Pertanian Universitas Siliwangi. Metode yang digunakan adalah metode kualitatif deskriptif. Data dan informasi hasil studi pustaka, observasi, wawancara mendalam, dan studi literatur dikumpulkan kemudian diseleksi dan dilakukan validasi terhadap bukti-butki pendukung yang ditemukan. Dari hasil kajian diketahui bahwa perguruan tinggi di Indonesia telah melakukan upaya secara terstruktur melalui kurikulum dalam penyelenggaraan pembelajaran kewirausahaan bagi mahasiswa. Konsep/model inkubasi agribisnis berperan dalam mewujudkan ketujuh pilar ekosistem kewirausahaan, namun demikian implementasi konsep tersebut terdapat pilar yang belum dilaksanakan sepenuhnya yaitu pilar regulasi yang mendukung, modal pembiayaan, serta pasar. Konsep inkubasi agribisnis disarankan untuk dapat menjadi instrumen dalam memperkuat proses penciptaan wirausaha baru yang berbasis komoditas pertanian bagi lulusan perguruan tinggi. The creation of reliable new entrepreneurs requires an entrepreneurial ecosystem. The concept of an agribusiness incubator has been implemented by several universities in Indonesia. This research was carried out by examining the concept of agribusiness incubation to develop an agricultural-based entrepreneurial ecosystem at the Faculty of Agriculture, University of Siliwangi. The method used is the descriptive qualitative method. Data and information from literature studies, observations, in-depth interviews, and literature studies were collected then selected and validated against the supporting evidence found. From the results of the study, it is known that universities in Indonesia have made efforts in a structured way through the curriculum in organizing entrepreneurship learning for students. The concept/model of agribusiness incubation plays a role in realizing the seven pillars of the entrepreneurial ecosystem, however, in the implementation of the concept some pillars have not been fully implemented, namely the pillars of supporting regulations, financing capital, and markets. The concept of agribusiness incubation is suggested to be an instrument in strengthening the process of creating new entrepreneurs based on agricultural commodities for university graduates.
Two Amnion-Derived Mesenchymal Stem-Cells Injections to Osteoarthritic Elbows in Dogs—Pilot Study

Simple Summary Osteoarthritis is a degenerative disease of synovial joints characterized by joint inflammation, damage of articular cartilage, and degenerative changes in periarticular tissues. The onset of lameness, pain, and joint stiffness are usually the first clinical signs observed by the owner. In recent years, many conventional therapies (NSAIDs, opioids, paracetamol, and gabapentinoids) for osteoarthritis have been described. Due to the complex mechanism of pain, multimodal analgesia in OA treatment is necessary. Unfortunately, conventional therapy does not offer the regenerative abilities of damaged tissue. However, mesenchymal stem cells have a definite advantage in chondrogenic, immunomodulatory, anti-apoptotic, and anti-fibrotic effects in joint environments in contrast to conventional therapies. Abstract The aim of the study was to investigate the potential of cell-based regenerative therapy for elbow joints affected by osteoarthritis. Interest was focused on two intra-articular applications of amnion-derived mesenchymal stem cells (A-MSCs) to a group of different breeds of dogs with elbow osteoarthritis (13 joints). Two injections were performed 14 days apart. We evaluated synovial fluid biomarkers, such as IFN-γ, IL-6, IL-15, IL-10, MCP-1, TNF-α, and GM-CSF, by multiplex fluorescent micro-bead immunoassay in the treated group of elbows (n = 13) (day 0, day 14, and day 28) and in the control group of elbows (n = 9). Kinematic gait analysis determined the joint range of motion (ROM) before and after each A-MSCs application. Kinematic gait analysis was performed on day 0, day 14, and day 28. Kinematic gait analysis pointed out improvement in the average range of motion of elbow joints from day 0 (38.45 ± 5.74°), day 14 (41.7 ± 6.04°), and day 28 (44.78 ± 4.69°) with statistical significance (p < 0.05) in nine elbows. Correlation analyses proved statistical significance (p < 0.05) in associations between ROM (day 0, day 14, and day 28) and IFN-γ, IL-6, IL-15, MCP-1, TNF-α, and GM-CSF concentrations (day 0, day 14, and day 28). IFN-γ, IL-6, IL-15, MCP-1, GM-CSF, and TNF- α showed negative correlation with ROM at day 0, day 14, and day 28, while IL-10 demonstrated positive correlation with ROM. As a consequence of A-MSC application to the elbow joint, we detected a statistically significant (p < 0.05) decrease in concentration levels between day 0 and day 28 for IFN-γ, IL-6, and TNF-α and statistically significant increase for IL-10. Statistical significance (p < 0.05) was detected in TNF-α, IFN-γ, and GM-CSF concentrations between day 14 and the control group as well as at day 28 and the control group. IL-6 concentrations showed statistical significance (p < 0.05) between day 14 and the control group.
AKTYVUMO IR DĖMESIO SUTRIKIMAS: EPIDEMIOLOGIJOS, SIMPTOMATIKOS, DIAGNOSTIKOS IR GYDYMO YPATUMAI

Asmenims, turintiems aktyvumo ir dėmesio sutrikimą, būdinga dar vaikystėje beprasidedanti simptomų gausa, skirstoma į du pagrindinius domenus: hiperaktyvumo (impulsyvumo) ir nedėmesingumo. Sutrikimas diagno­zuojamas, kai jis trunka ilgiau nei 6 mėnesius, daugiau nei dviejose gyvenimo srityse ir trukdo paciento visa­verčiam funkcionavimui. Diagnostikai gali būti pasitel­kiamos įvairios priemonės ar kriterijai, kurie tarpusavyje skiriasi, priklausomai nuo to, ar pacientas yra vaiko, ar suaugusiojo amžiaus. Aktyvumo ir dėmesio sutrikimas gydomas medikamentais – pirmo pasirinkimo preparatai yra psichostimuliantai. Kartu su psichofarmakoterapija, rekomenduojama taikyti ir kitus, moksliniais duomeni­mis paremtus nefarmakologinio gydymo pasirinkimus, kaip kognityvinė elgesio terapija, organizacinių įgūdžių lavinimas, hipnoterapija, kt.
The Extract Of Ophiocephalus Striatus Affect Levels Of TNF-Α, TGF-Β1, IL-17 And SuPAR, Pulmonary Diffusing Capacity For Carbon Monoxide, And Health-Related Quality Of Life In Stable COPD Patients With Muscle Wasting

Objective — This study aimed to evaluate the effect of Ophiocephalus striatus extract on body composition, levels of TNF-α, TGF-β1, IL-17, suPAR and neutrophils, diffusing capacity of the lungs for carbon monoxide (DLCO) and health-related quality of life (HRQoL) in stable COPD patients with muscle wasting. Methods — Clinical pre- and post- quasi-experimental study of 32 stable COPD patients with muscle wasting from the Pulmonary Outpatient Clinic of Saiful Anwar General Hospital Malang, determined in accordance with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2016 and bioelectrical impedance analysis (BIA) measurements (FFM <14.6 kg/m; BMI <18.5 kg/m2). Measurements of the following health-related parameters for the QoL due to COPD were performed before and after the nutritional intervention of 3,000 mg of O. striatus extract daily for 12 weeks: TNF-α, TGF-β1, IL-17 and suPAR levels (by ELISA), neutrophils (by blood test), DLCO (by body plethysmography), and CAT score. Results — A non-significant reduction of TNF-α (p=0.302), IL-17 (p=0.275), neutrophil (p=0.619), and suPAR (p=0.674) levels, along with an increase in DLCO (p=0.369), occurred after 12 weeks of O. striatus extract administration. However, the level of TGF-β1 declined significantly (p=0.022), followed by an increase in QoL as assessed by the CAT score (p=0.000). There was no significant correlation between inflammatory cytokines and DLCO, nor with the CAT score. Conclusion — The study results demonstrated a potential role of oral nutritional supplementation in the management of COPD patients with muscle wasting.
Ursolic acid ameliorates obesity of mice fed with high-fat diet via alteration of gut microbiota and amino acid metabolism

Obesity has been regarded as one of the major health problems worldwide. Studies demonstrated that ursolic acid (UA) can significantly ameliorate the progress of obesity. However, whether the effect of UA on obesity depends on the regulation of gut microbiota and metabolism is uncertain. To investigate the regulatory role of UA in obese mice from the perspective of intestinal microbiome and metabolomics analyses, an obese mice model was established with a high-fat diet, and the effect of UA on obesity was evaluated. The alterations of gut microbiota and metabolism related to obesity were evaluated by bioinformatic analysis. The results of the gut microbiota analysis showed that UA intervention could shift the Firmicutes to Bacteroidetes ratio at the phylum level and increase in the genera of Lactobacillus, Bacteroides, and Akkermansia. Additionally, metabolomics analysis showed that the beneficial influence of UA on obesity partly depended on amino acid metabolism. The current study demonstrated the roles of UA in the anti-obesity process, which depends in part on alterations in the gut microbiota and metabolism. Therefore, our findings highlight the potential therapeutic effect of UA on the improvement of diet-induced obesity in humans.
Factors Predicting Influenza Vaccination Adherence Among Patients Undergoing Dialysis in Taif City, Saudi Arabia: A Cross-Sectional Study

Background: Influenza infection can cause severe complications and hospitalization in patients with end-stage renal disease. Despite the importance of influenza vaccination in preventing such complications, adherence to vaccination among these patients is often inadequate. Objective: To investigate the factors that predict influenza vaccination adherence among patients undergoing in-center dialysis in Taif City, Saudi Arabia. Methods: Analytical cross-sectional study was conducted in dialysis units of different hospitals in Taif City, Saudi Arabia. A predesigned questionnaire was used for data collection which included questions related to sociodemographic characteristics, knowledge about influenza vaccination, perceived risks of influenza infection, and vaccine-related questions. Results: A total of 463 individuals were included in the analysis. The median score for knowledge was 6/10, with 60.9% of patients demonstrating good knowledge. In terms of vaccination status, 64.1% had received the influenza vaccine for the current year, with 47.3% adhering to yearly vaccination, 23.1% receiving vaccines irregularly, and 29.6% never receiving the vaccine. Among those who did not receive the vaccine, 21.8% were concerned about the side effects, 15.1% did not believe in the vaccine's effectiveness, and 14.5% were influenced by the media. Adherence to vaccination was significantly associated with good knowledge (OR=2.4), a higher perceived risk of hospitalization (OR=2), and a higher perceived risk of death (OR=2.2). Conclusion: In conclusion, the study reports predictors that influence influenza vaccine adherence among patients receiving dialysis in Saudi Arabia. Furthermore, the study highlights the importance of knowledge, perceived risk, and healthcare workers' advice in influenza vaccine adherence among patients receiving dialysis.
Ion-Cyclotron Resonance Heating of O+ in the Topside Ionosphere and Mapping Outflows to the Magnetosphere

This thesis considers the heavy ion dynamics due to ion-cyclotron resonance energization processes that take place in the turbulent region of the Earth’s topside, high latitude ionosphere. We simulate the impact of this transverse heating process upon energies and velocity distribution functions of outflowing oxygen ions (O+) in the approximate altitude range of 800 km to 15,000 km. To do so most effectively, we use a single particle tracing model that precisely reproduces the small-scale wave-particle interaction of broadband extremely low frequency (BBELF) waves with the ions’ cyclotron motions, leading to the upward acceleration of ions in type-II ion outflows and ion conics. Instead of employing the guiding center approximation, as is usually done with single particle tracing models in order to make the outflow simulation less computationally expensive, the trajectories here resolve the ions’ full gyro-motion. The model’s uncustomary approach is validated by its ability to contribute statistical results via Monte Carlo simulation which reflect, at least qualitatively, previous observations of transversely energized distribution functions–ion conics. The effects of parallel potential drops and coherent energization upon the distribution functions are are also examined. In addition to the above result which uses a simple dipole Earth magnetic field to recreate expected ion conic distribution functions, an adaptation of the model is used to map the trajectories of transversely energized O+ ions throughout a realistic NASA: BATSRUS Earth magnetosphere in order to determine probabilistic magnetospheric destinations and escape likelihood for the ions. A multipleparticle tracing technique is employed to qualitatively demonstrate the potential of this model for investigating sources and fates of ion outflows. The use of NASA:
A Prospect for Genome Wide Association Studies in Crops

Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants across many genomes to find those statistically associated with a specific trait or disease. A Comprehensive review of studies on biotic resistance, abiotic tolerance, yield-associated characteristics, and metabolic composition is provided. Genome-wide SNP maps have characterized population structure concerning the geographic origin and morphological type and identified patterns of ancient crop diffusion to diverse agroclimatic regions. To better understand the genomic patterns of crop diversification, nucleotide diversity variation, linkage disequilibrium, and recombination rates across the genome are quantified. Results from GWAS can be used for a range of applications. The GWAS approach has proven highly suitable for identifying common SNP-based variants with moderate to significant effects on phenotype. However, the genetic factors underlying some of these associations have been characterized. The vast majority remain unexplained. The development of next-generation sequencing and bioinformatics tools has dramatically improved and is currently being implemented to decipher the genetic diversity of targeted traits. The significant drawbacks are the need for large population size, the cost of preparing DNA samples, and less knowledge about the risk of the quality. To overcome this drawback, researchers have upgraded the statistical approaches, proper imputation of genotypes, and advanced approaches such as nested association mapping and candidate gene association mapping. The primary benefit is one-time genotyping and repeated phenotyping in different environmental conditions. Int. J. Appl. Sci. Biotechnol. Vol 11(2): 54-59.
A Bi-Objective Simulation Facility for Speed and Range Calibration of 24 GHz and 77 GHz Automotive Millimeter-Wave Radars for Environmental Perception

Automotive millimeter-wave radars are widely used to measure kinematic parameters of surrounding objects in the environmental perception of automated vehicles and typically operate in frequency bands of around 24 GHz and 77 GHz. The 24 GHz and 77 GHz automotive millimeter-wave radars are similar in their speed and range measurement principles; however, they are distinct in their accuracies when measuring the above kinematic parameters because of the different carrier frequencies and bandwidths. In order to evaluate the kinematic parameter measurement performances of automotive millimeter-wave radars for environmental perception, this paper proposes a calibration method and establishes a bi-objective simulation facility for the speed and range calibration of 24 GHz and 77 GHz automotive millimeter-wave radars. The feasibility of the proposed calibration method and the accuracy of the established bi-objective simulation facility are verified by the results obtained via experiments conducted on two 24 GHz and 77 GHz millimeter-wave radar samples. According to the speed and range calibration results of the two millimeter-wave radar samples, the 77 GHz millimeter-wave radar sample possesses superior speed measurement accuracy compared with the 24 GHz sample. Additionally, the range measurement errors of the 77 GHz millimeter-wave radar sample are much smaller than those of the 24 GHz sample. This indicates that the 77 GHz millimeter-wave radar sample is more accurate and reliable than the 24 GHz sample. Finally, the 77 GHz millimeter-wave radar sample was tested for its speed and range resolving ability. The results confirm that the bi-objective simulation facility can satisfy the calibration requirements of speed resolution up to 0.01 m/s and range resolution up to 0.1 m. The proposed calibration method and the established simulation facility can easily satisfy the speed, range and resolution calibration requirements of 24 GHz and 77 GHz millimeter-wave radars with high precision and wide range, and can achieve more economical, comprehensive and traceable performance testing on both 24 GHz and 77 GHz automotive millimeter-wave radars for environmental perception.
High serum lactate dehydrogenase levels as a prognostic marker for morbid perinatal outcome in pre eclampsia

Introduction : Hypertension during pregnancy is an important causative factor of perinatal and maternal morbidity and mortality globally. There are several biochemical markers like ALP, AST, ALT, LDH, Uric acid to ascertain the severity of disease. The aim of our study was to determine the effectiveness of lactate dehydrogenase as a prognostic marker in assessing the sequalae of preeclampsia. Materials and Methods : This analysis was conducted at RMMCH in the Department of OB-GYN for a period of 2 years (2016-2018). It was a prospective case control study. A total of 60 antenatal mothers were included in the study, of which 30 were healthy pregnant females and 30 were pre eclamptics. Results: The mean values of serum LDH levels were found to be high in preeclamptics compared to normotensives which was significant statistically (p value of < 0.001). Adverse perinatal effects were seen in females with raised LDH levels (p value of <0.005). Conclusion : Serum LDH can be utilized as a prognostic marker to ascertain the severity of preeclampsia and it can also be used as a marker to predict the perinatal and maternal outcome.
Asymptotic Stability of Quaternion-based Attitude Control System with Saturation Function

In the design of attitude control, rotational motion of the spacecraft is usually considered as a rotation of rigid body. Rotation matrix parameterization using quaternion can represent globally attitude of a rigid body rotational motions. However, the representation is not unique hence implies difficulties on the stability guarantee. This paper presents asymptotically stable analysis of a continuous scheme of quaternion-based control system that has saturation function. Simulations run show that the designed system applicable for a zero initial angular velocity case and a non-zero initial angular velocity case due to utilization of deadzone function as an element of the defined constraint in the stability analysis.
Sex estimation from virtual models: exploring the potential of stereolithic 3D crania models for morphoscopic trait scoring

Abstract Modern computed tomography (CT) databases are becoming an accepted resource for the practice and development of identification methods in forensic anthropology. However, the utility of 3D models created using free and open-source visualization software such as 3D Slicer has not yet been thoroughly assessed for morphoscopic biological profiling methods where virtual methods of analysis are becoming more common. This paper presents a study that builds on the initial findings from Robles et al. (2020) to determine the feasibility of estimating sex on stereolithic (STL) 3D cranial models produced from CT scans from a modern, living UK population (n = 80) using equation 2 from the Walker’s (2008) morphoscopic method. Kendall’s coefficients of concordance (KCC) indicated substantial agreement using cranial features scores in an inter-observer test and a video-inter-observer test. Fleiss’ Kappa scores showed moderate agreement (0.50) overall between inter-observer sex estimations, and for observer sex estimations in comparison to recorded sexes (0.56). It was found that novice users could virtually employ morphoscopic sex estimation methods effectively on STL 3D cranial models from modern individuals. This study also highlights the potential that digital databases of modern living populations can offer forensic anthropology. Key points First example of Walker’s (2008) method applied to a living UK population. Open-source software is a valuable resource for crime reconstruction approaches. Male scoring bias was observed in method application. Forensic anthropologists would benefit from virtual anthropology training to use and interpret 3D models. Digital databases offer more ethical, diverse, modern populations for future research.