Miracle-dz/UniFAR-FTUs huggingface dataset:
Successful Treatment of Refractory Thrombotic Thrombocytopenic Purpura (TTP) With Caplacizumab: A Case Report

We report a female patient who presented with generalized weakness, episodes of altered mental status and slurred speech, and a history of systemic lupus erythematosus. Initial investigations showed profound thrombocytopenia and schistocytosis on peripheral blood smear. PLASMIC score was promptly calculated, and plasma exchange with steroids was initiated based on the initial high PLASMIC score. Bone marrow examination showed hypocellular marrow without any other obvious abnormalities. The patient’s platelet counts initially improved but had a quick decline, on which, rituximab and subsequently caplacizumab were introduced. The patient was discharged after stabilization with plasma exchange (PLEX) therapy as needed on an outpatient basis.
Compact Dual Slot SIW Cavity Backed Antenna for CubeSat/Nanosatellite Applications

In this article, a small aperture coupled SIW cavity-backed dual slot antenna is presented. It is demonstrated that, for a rectangular SIW cavity with dual slot, when the feed point is chosen properly, the structure can resonate at much lower frequency than that of the conventional SIW cavity mode frequency. An equivalent cavity model is formed; a formula for the calculating the operating frequency and a general design guideline are provided for this structure. The designed prototype antenna provides a gain of 8.41 dBi at 15 GHz. For high-gain applications, a $2\times4$ array of such element is demonstrated. An experimental validation of the array results in a gain of 16.01 dBi. The structure is compact, offers a broadside radiation pattern, easy to integrate with metallic surface, and has inherent property of reducing mutual coupling. As a result, it can find application in CubeSat/SmallSats where space is among the major constraints and components are very closely packed. It can be used in CubeSat missions for earth and planetary observations, intersatellite communications, and in MIMO systems for SmallSat swarms.
Using storytelling to explore values and cognitive schemas in small group consensus decision making

This activity engages students in values-based decision making using a story about five characters caught up in a morally fraught dilemma. Students draw conclusions about each character based on perceptions of their actions, rather than explicitly stated attributes, as they interact with one another to reach a consensus ranking from best to worst. The activity incorporates storytelling with the Integrated Model to highlight the impact of cognitive schemas on group decision-making processes. Courses Small Group Communication, Basic/Introductory Communication Course with a small-group component. Objectives Through a storytelling activity, students apply a cognitive schemas framework to identify individual-level, values-based variables influencing small-group consensus decision making.
Graph Reconstructed Tensor Subspace Analysis

Tensor Subspace analysis (TSA) is typical tensor space analysis method, which can obtain the projection matrixes by building an adjacency graph to model the local geometrical structure of the manifold, and has been successfully applied in many practical problems. But the essential neighbor graph constructed suffers from the following issues: the k-neighbor is computed by the whole image matrix, which leads to the lost of the correlative columns information, the graph can not express the geometrical and discriminative structures of the original data space accurately. Based on a general platform of graph embedding, we proposed a graph reconstructed tensor subspace analysis (GRTSA) which will better express the spatial structure information of the original image matrices, preserving the corresponding inter-column locally information. Real face recognition experiments show the superiority of our proposed GRTSA in comparison to TSA, also for corresponding supervised and unsupervised extensions.
A Pilot Study on the Effectiveness of Prazosin as a Treatment of Post-Traumatic Stress Disorder-Related Nightmares in Women with Bulimia Nervosa

Objectives Post-traumatic stress disorder (PTSD) symptoms are reported in over 36% of individuals with bulimia nervosa. To date, none of the clinical trials have examined nightmare reduction in this population. We evaluated the effectiveness of prazosin in bulimic females experiencing PTSD-related nightmares. We hypothesized that prazosin will decrease nightmares, normalize cortisol levels and secretory patterns, and improve sleep. Methods Our seven-week prospective, randomized, double-blind, placebo-controlled crossover pilot trial recruited eight adult women. Each participant received three weeks of prazosin and a placebo, separated by a one-week washout period. The order of treatment was counterbalanced across participants. Self-reports, clinician-administered scales, and salivary cortisol was collected to measure outcomes. Results A significant treatment effect was seen in nightmare intensity on the Clinician-Administered PTSD Scale (CAPS-I) (p=0.026) and a marginally significant effect on nightmare frequency (p=0.069). The only significant main effect of treatment on self-reported sleep parameters was on nightmares. Cortisol secretory patterns did not change, but on average, study participants had significantly higher cortisol levels compared to normative values. ANOVA showed a significant main effect of time for cortisol (F(4, 28) = 6.15, p=. 001) but no within or between groups significant effects (ps>.179). Follow-up tests showed the effect of time was linear (F(1, 7) = 10.77, p=. 013). Conclusion Prazosin significantly reduced intensity and marginally reduced the frequency of PTSD-related nightmares in bulimia nervosa but did not affect subjective sleep efficiency, quality, cortisol levels, or diurnal cortisol secretory pattern. Larger trials using objective sleep measures are warranted to replicate these findings.
A decade's difference: 10-year change in insomnia symptom prevalence in Canada depends on sociodemographics and health status

Introduction: Insomniaisrecognizedasapublichealth issue.Theobjectives ofthisstudy weretocharacter-ize and compare the prevalence of insomnia symptoms in the Canadian population in 2002 and 2012, and to identify sociodemographic and psychosocial predictors of trouble sleeping. Methods: Data from adult participants in the Canadian Community Health Survey – Mental Health cycles 2000-2002 (n = 34,118) and 2011-2012 (n = 23,089) were used. Participants responded to the question “ How often do you have trouble going to sleep or staying asleep? ” , with those who indicated “ most of the time ” or “ all of the time ” classi ﬁ ed as having insomnia symptoms. Logistic regressions, adjusted for covariates, were used to examine differences between cycles. Results: The unadjusted prevalence of insomnia symptoms increased from 15.6% to 17.1% between 2002 and2012,representinganabsoluteincreaseof1.5%. Thelikelihoodofinsomniasymptomswassigni ﬁ cantly in ﬂ uenced by age,sex, education, physical health, and mental health status. A 3-way year-age-sex interaction was statistically signi ﬁ cant such that women aged 40-59 demonstrated approximately 29% increased likelihood of insomnia symptoms from 2002 to 2012. This was reduced to 24% when adjusted for physical and mental health. There were no signi ﬁ cant differences for men across age groups. Conclusion: Over a 10-year period, the prevalence of insomnia symptoms increased in Canada. This trend appears to be driven in part by greater levels of insomnia symptoms among middle-aged women.
Robust Fault-Tolerant Estimation of Sideslip and Roll Angles for Distributed Drive Electric Buses With Stochastic Passenger Mass

Faults or data loss of onboard sensors are a critical concern for active safety control of distributed drive electric buses (DDEBs). In this article, a robust fault-tolerant estimation (RFTE) method is proposed to estimate sideslip and roll angles of DDEB in spite of stochastic disturbances and sensor faults. Considering the effects of sensor faults, stochastic passenger mass and modeling errors on DDEB active safety control, an augmented system consisting of DDEB states and associated sensor faults is firstly constructed, where the disturbances caused by passenger mass and modeling errors are merged as unknown input vector. Then, by decoupling partial disturbances, an unknown input observer is developed to estimate the augmented system states, while a linear matrix inequality and an estimated states correction method are introduced to further attenuate the effects of residual disturbances and thus guarantee the accuracy of the estimation. Finally, the validity of the proposed RFTE method is evaluated by a Trucksim-Simulink co-simulation platform and a hardware-in-the-loop platform. The experimental results demonstrated that the proposed RFTE method can achieve effective estimation in the presence of stochastic disturbances and sensor faults, exhibiting better robustness and reliability than existing baseline estimation method.
Testing the iC/CMB Model for X-ray Emission: Constraining the Orientation of Extragalactic Jets

The purpose of this research is to test the inverse–Compton/Cosmic Microwave Background (or iC/CMB) model for X–ray emission from radio jets. Andreas Rauch of the Brandeis Physics Department has developed methods for constraining the orientation of extra–galactic radio jets. We will apply these constraints to jets detected by the Chandra X–Ray Observatory. By doing so, we perform a strong test of whether the iC/CMB mechanism is viable.
Pengaruh Kepemimpinan dalam Peningkatan Motivasi Kerja PNS di Kantor Kecamatan

Abstract This study aims to determine the influence of sub-district leadership on increasing the work motivation of civil servants in Bontomatene District, Selayar Regency. This research was conducted in the area of ​​the Bontomatene District Office, Selayar Regency. In this study the authors used a survey research basis. While the type of research used was to obtain research data, the population used by the author was all employees of the Bontomatene District office, Selayar Regency, while the informants were the Bontomatene Sub-District Head and the Bontomatene Sub-District Secretary. The sampling technique in this study is the purposive sample method. To collect the required data the author collects data through: Library research, field research, interviews, questionnaires and online data tracking. The collected data will be analyzed using a qualitative approach. The results of the research show that the leadership of the sub-district head which influences employee motivation seen from planning is quite good. This can be seen with an average score of 2.2 which shows that the planning carried out by the Bontomatene Sub-District Head is in the moderate category. All employees have been involved in planning the sub-district work program, but the resulting score is still in the moderate category. Therefore, employee involvement still needs to be improved. In addition to planning indicators, researchers also use indicators of effective communication. The communication carried out by the Bontomatene sub-district head to his subordinates still needs to be improved.
The measurement of breaking waves using particle image velocimetry

Instantaneous, full field velocity measurements have been achieved under the crest of a laboratory generated breaking wave. Measurements are made to within a few millimeters of the surface and covering an area of several hundred cm2. The generation of the waves is achieved by means of a computer controlled wave paddle and measurements are made using a full field photographic technique(PIV). The photographic records of the flow are analysed by a fully automatic rig and the measurements shown to compare well with calculated velocities from a time stepping numerical model of a similar wave.Instantaneous, full field velocity measurements have been achieved under the crest of a laboratory generated breaking wave. Measurements are made to within a few millimeters of the surface and covering an area of several hundred cm2. The generation of the waves is achieved by means of a computer controlled wave paddle and measurements are made using a full field photographic technique(PIV). The photographic records of the flow are analysed by a fully automatic rig and the measurements shown to compare well with calculated velocities from a time stepping numerical model of a similar wave.
Numerical Evaluation of Sintered Silver Die Attachments Based on Different Material Parameters and Creep Constitutive Models

Finite element analysis (FEA) is perhaps the most popular technique used for simulating the thermally induced failures of sintered silver die attachments in power electronics. The accuracy of the stress-strain relationship estimations of power electronics is highly influenced by the material mechanical properties and the creep constitutive models used throughout the simulations. Therefore, the current article aims to investigate several Anand-based material properties of the sintered silver bonds considering several mechanical creep constitutive models effect of thermal fatigue life of sintered silver bonds using extensive 3-D FEA thermomechanical simulations. In this investigation, the FEA models are first correlated with the displacement results of the digital image correlation (DIC) experiments. Furthermore, the effect of the material parameters and creep models on the solder stresses, strains, and inelastic strain energy densities and hence on the lifetime predictions of the die attachment layer is discussed in detail. The results showed that the solder behavior is highly dependent on the material parameters as well as creep modeling. Finally, a detailed discussion on the effect of such discrepancies on the predictions and evaluations of sintered silver die attachments fatigue life is also presented.
Analysis of the Comorbid Course of Chronic Obstructive Pulmonary Disease

(1) Background. Chronic obstructive pulmonary disease (COPD) has a heterogeneous natural history, manifested both in the variability of clinical features and in association with various comorbid pathologies. Atherosclerotic cardiovascular disease (ASCVD) is of great clinical importance and contributes significantly to the natural history and prognosis of COPD. The present study aimed to evaluate the nature of the comorbid course of COPD during a 15-year follow-up. (2) Methods: A total of 170 male COPD patients were included in this study. Spirometry values, symptom severity, presence of risk factors, and comorbidities were considered. Prognostic factors were evaluated using the Kaplan–Meier method. (3) Results: ASCVD was the most common comorbidity and the main cause of death in patients with COPD. Patients with comorbid COPD and ASCVD had more severe dyspnea, higher frequency of COPD exacerbations, and worse survival than patients without ASCVD (p < 0.01). Among patients with COPD, the risk of death from ASCVD was higher in those older than 60 years (OR 3.23, 95% CI [1.72, 6.07]), those with rapidly declining FEV1 (OR 4.35, 95% CI [2.28, 8.30]), those with more than two exacerbations per year (OR 3.21, 95% CI [1.71, 6.11]), and those with a pack year index greater than 30 (OR 2.75, 95% CI [1.38, 5.51]. High Charlson comorbidity index scores in patients with COPD were associated with a more severe disease course, including severity of dyspnea, frequency of exacerbations, and multivariate index scores. A high Charlson comorbidity index score was an adverse prognostic factor. (4) Conclusions: ASCVD influences the course of the disease and is a major cause of mortality in COPD patients.
Systematic Cryptanalysis of PUF-Based Authentication Protocols for IoT, A Case Study

Almost all IoT applications require secure user authentication protocols. Due to the limitations of most IoT devices and the possibility of physical attacks, lightweight authentication protocols based on Physical Unclonable Functions (PUF) are widely used. To design an efficient scheme, it is helpful to learn weaknesses of existing protocols and provide guidelines for future protocol designers. In this letter, using a formal framework, we discuss the vulnerabilities of a recent PUF-based protocol proposed by Gope et al. We prove our claims concerning protocol vulnerabilities in this framework according to propositional logic. Moreover, we suggest countermeasures for improving the protocol’s security.
Seed dormancy, germination and seed storage in henna (Lawsonia inermis)

Henna (Lawsonia inermis L.) is an important commercial plant of India grown mainly for its leaves used for dying hair, skin etc. The seeds of henna are small typically pyramidal, endospermic with a linear embryo. The freshly harvested seeds show endogenous non-deep physiological dormancy and pre-treatment of seeds, viz. leaching, chilling, priming, GA3 and KNO3 co-application reduced dormancy. The physiological dormancy was transitory and disappeared during storage due to after-ripening. Seed storage studies revealed that seeds with 5 and 7 % moisture content did not show significant reduction in seed longevity up to 24 months in ambient storage in comparison to seeds with higher moisture content. Seed deterioration was slow at 15 and â€“20oC storage temperatures. The seeds are desiccation as well as chilling tolerant, therefore, exhibit orthodox seed storage behaviour which makes them ideal for ex-situ conservation in seed banks for long term storage.
Plasticidad fenotípica de plántulas de Anacardium occidentale L. al estrés salino en base a indicadores fisiológicos

El estudio de la respuesta al estrés salino a partir de indicadores fisiológicos en genotipos de marañón (Anacardium occidentale L.), contribuye al conocimiento de los mecanismos adaptativos de esta especie a condiciones estresantes. El objetivo de esta investigación fue analizar la plasticidad fenotípica y la variación en indicadores relacionados con la fotosíntesis en dos genotipos (rojo y amarillo) de Anacardium occidentale L. , durante la fase de plántulas en condiciones de invernadero. Se evaluó el efecto de cinco niveles de salinidad (0.02 dS m-1, 5 dS m-1, 10 dS m-1, 15 dS m-1 y 20 dS m-1) sobre caracteres asociados a la fotosíntesis, intercambio gaseoso y la fluorescencia de la clorofila. Se calculó la plasticidad fenotípica en respuesta al estrés salino de los indicadores evaluados a través del índice de plasticidad fenotípica. La variedad roja mostró las mayores afectaciones producto del estrés salino en los indicadores tasa fotosintética, transpiración, CO2 subestomático, Fm, Fv, Fv/Fm, Fv/Fo y Pi abs. Las diferencias significativas encontradas en cuanto a la plasticidad fenotípica mostraron valores superiores en la variedad roja en la mayoría de los indicadores evaluados. Se muestra el efecto negativo que tiene la salinidad en el estadio de plántulas en los indicadores relacionados con la fotosíntesis, intercambio gaseoso, y fluorescencia de la clorofila, así como las diferencias significativas existentes en cuanto a los indicadores evaluados y los niveles de plasticidad fenotípica de los mismos entre genotipos. La fotosíntesis y la conductancia estomática fueron los indicadores que mostraron los mayores valores de plasticidad fenotípica.
Implementasi Sintesis Suara Saron Menggunakan Petikan Senar Gitar Dengan Metode Pitch Shifting

Gamelan is traditional Indonesian musical instruments that is often used in traditional events and parties.The community's need for the gamelan has actually increased, but unfortunately the price of gamelan is very expensive and the gamelan itself is difficult to move from one place to another place. Besides that, the limited tones that can be played by gamelan reduce the level of public interest in playing this instrument. Current technological developments make it possible to perform voice synthesis with several methods. One method that can be used is pitch shifting.This study aims to generate a synthetic saron sound based on plucking a guitar string. Analysis of the saron sound signal in the frequency domain is carried out to obtain the semitone values needed in the synthesis process. Synthetic saron signal generation is done by calling synthetic saron sounds that are stored in soundfont form, with reference data in the form of high and low pitch obtained from the guitar input pitch detection. Onset detection of guitar strokes is used as the initial trigger for calling out synthetic saron tones. The test was carried out by looking for similarities between the sound data of the original saron and synthetic saron using the cross-correlation method. The test results obtained a similarity accuracy rate of 91.6%. On the results of testing the guitar strum signal with the generation output, the average delay time for each strum is 0.152 seconds. From the results obtained, the system is classified as fast and accurate enough to be implemented in everyday life.
Molecular signature associated with cladribine treatment in patients with multiple sclerosis

Introduction Little is known about the molecular profiling associated with the effect of cladribine in patients with multiple sclerosis (MS). Here, we aimed first to characterize the transcriptomic and proteomic profiles induced by cladribine in blood cells, and second to identify potential treatment response biomarkers to cladribine in patients with MS. Methods Gene, protein and microRNA (miRNA) expression profiles were determined by microarrays (genes, miRNAs) and mass spectrometry (proteins) in peripheral blood mononuclear cells (PBMCs) from MS patients after in vitro treatment with cladribine in its active and inactive forms. Two bioinformatics approaches to integrate the three obtained datasets were applied: (i) a multiomics discriminant analysis (DIABLO - Data Integration Analysis for Biomarker discovery using Latent variable approaches for Omics studies); and (ii) a multi-stage integration of features selected in differential expression analysis on each dataset and then merged. Selected molecules from the in vitro study were quantified by qPCR ex vivo in PBMCs from MS patients receiving cladribine. Results PBMCs treated in vitro with cladribine were characterized by a major downregulation of gene, protein, and miRNA expression compared with the untreated cells. An intermediate pattern between the cladribine-treated and untreated conditions was observed in PBMCs treated with cladribine in its inactive form. The differential expression analysis of each dataset led to the identification of four genes and their encoded proteins, and twenty-two miRNAs regulating their expression, that were associated with cladribine treatment. Two of these genes (PPIF and NHLRC2), and three miRNAs (miR-21-5p, miR-30b-5p, and miR-30e-5p) were validated ex vivo in MS patients treated with cladribine. Discussion By using a combination of omics data and bioinformatics approaches we were able to identify a multiomics molecular profile induced by cladribine in vitro in PBMCs. We also identified a number of biomarkers that were validated ex vivo in PBMCs from patients with MS treated with cladribine that have the potential to become treatment response biomarkers to this drug.