Miracle-dz/UniFAR-FTUs huggingface dataset:
Studium interakcí iontů s hyaluronanem metodou molekulové dynamiky (virtuální experiment)

The thesis phenomenologically describes the interaction of hyaluronan with various ions based on simulations using the method of molecular dynamics in NAMD program. The results of simulation the thesis puts into context with the previously published theories and hypotheses, such as the Hofmeister series of ions and the ions pairing with similar affinity to water.
Factors influencing collection development process at the University of Nairobi Library

PurposeThe purpose of this study was to investigate the factors influencing the collection development process at the University of Nairobi library and suggest ways for improvement.Design/methodology/approachA qualitative approach was employed to collect, analyze and interpret data from collection development librarians at the University of Nairobi purposively selected. Data were collected through structured interviews and documentary review. Data were analyzed using content analysis and descriptive statistics.FindingsThe study established that the library has a written collection development policy which was revised in 2014 and is strictly adhered to. However, the policy has a gap on the role of faculty as stakeholders in the selection process. In addition, the criteria for selection are not explicitly stated. Findings also indicate that budget allocation, collection development policy, user demands, quality of staff, library consortium and the Public Procurement and Asset Disposal Act of 2015 influence the collection development process at the University of Nairobi Library.Research limitations/implicationsThe study was conducted in one public university library in Kenya. However, the findings may be applicable in similar university libraries in the country.Practical implicationsThe findings of this study may benefit students and faculty in the University of Nairobi from improved collection development process that would ensure that their information needs are met in a timely manner. This would lead to improved research output by students and faculty and ultimately improved research output by the university. University library management may also benefit in improving the collection development process, thereby making it more economical. The findings may also be useful in decision-making and policy development on matters pertaining to collection development at the University of Nairobi and other universities. Furthermore, the findings may be used by researchers to provide context and background information for future research on collection development in public universities locally and regionally.Originality/valueThis paper fulfills the need to make the collection development process in university libraries more efficient by proposing ways of addressing the challenges experienced.
Biosimilar Interchangeability and Emerging Treatment Strategies for Inflammatory Bowel Diseases: A Commentary

This commentary summarizes a collection of key references published within the last ten years, and identifies pharmacologic research directions to improve treatment access and success through greater biosimilar or “follow-on” biologic utilization combined with other targeted small molecule agents that possess unique pathophysiologic mechanisms for inflammatory bowel diseases (IBD) in adult and pediatric patients. Since they are not identical to the originator or reference biologic agent, all biosimilars are not generically equivalent. However, in the US and other countries, they are considered therapeutically interchangeable if the manufacturer has demonstrated no clinically meaningful differences from the reference product. Comparisons of different clinical initiation and switching scenarios are discussed with reference to interchangeability, immunogenicity, nocebo effect, cost effectiveness, and time courses for discontinuation rates.
Microbial Exposure Assessment of Fresh and Smoked Pork Meat within Ado-Ekiti Metropolis, Nigeria

The breeding and production environments of pigs tend to be exposed to microbial contaminations and could portend a potential public health hazard if not well managed. This study investigated bacterial and fungal loads of commercial fresh and smoked pork in order to ascertain their wholesomeness. Total aerobic bacterial and fungal count were done on nutrient agar and potato dextrose agar respectively, while antimicrobial susceptibility test to selected commercial antibiotic discs carried out using Disk Diffusion Technique. All the twenty samples (Fresh and Smoked) cultured yielded bacterial growth with a range of 2.2 - 9.0 × 104 CFU/g (smoked) to 1.0 – 6.3 × 106 CFU/g (fresh). On the other hand, the fungal loads ranges from 1.0 – 6.0 × 102 CFU/g(smoked) to 1.0 -5.0 × 104 CFU/g (fresh). The bacterial isolated and the ratios in fresh and smoked samples wereStaphylococcus aureus (6: 11), Escherichia coli (5: 8), Bacillus cereus (4: 7), Salmonella spp. (2: 3), Proteus spp. (0: 4), Enterobacter spp. (1: 2), Shigella spp. (0:2) and Pseudomonas aeruginosa (1: 0), while their fungal counterpart included Aspergillus niger (4: 2), Aspergillus terreus (2; 2),Fusarium oxysporum(4: 0), Penicillium spp. (4: 2), Rhizopus spp. (3: 5), Mucor spp. (0: 4); Geotricum candidum (0: 2) and Microsporium spp. (0: 2). Most of the S.aureus (> 58.8%) and P. aeruginosa (100%), and B. cereus (100%) demonstrated remarkable resistance to the majority of the tested antibiotics. These findings are of public health concern because most of the bacterial and fungal isolates have been implicated in foodborne infections. Hence, there is a need for stricter sanitary measures during the rearing and production to reduce the level of microbial contaminations.
Economic and environmental impacts of scrubbers investments in shipping: a multi-sectoral analysis

ABSTRACT The International Maritime Organization (IMO) has implemented a series of increasingly stricter regulations to reduce sulphur emissions from international shipping. As of January 2020, the global sulphur cap requires the use of fuel containing a maximum of 0.5% sulphur content, or the use of technology achieving a similar reduction in sulphur emissions. Deciding between fuel switching or investing in abatement technologies has been a recurring topic for research in the last decade, with a focus on shipping activities within Emission Control Areas (ECAs). The quest for the desulphurization of shipping results in higher operating costs as well as CO2 emissions. We estimate the economic and environmental impacts of compliance with sulphur limits for a variety of representative ship types. This paper quantitatively assesses case studies across the most important shipping sectors highlighting their different challenges. The results confirm that scrubber investments are more profitable at times of higher fuel prices, and for ships that spend relatively more time sailing. We show that the potential for speed differentiation inside and outside ECAs has been diminished. This framework can be a useful decision support system for selecting the best response amongst different compliance options to environmental regulations.
Integrating habitat suitability modelling and assessment of the conservation gaps of nature reserves for the threatened Reeves’s Pheasant

Summary As threats to biodiversity proliferate, establishment and expansion of protected areas have increasingly been advocated in recent decades. In establishing a network of protected areas, recurrent assessments of the biodiversity conservation actually afforded by these areas is required. Gap analysis has been useful to evaluate the sufficiency and performance of protected areas. We surveyed Reeves’s Pheasant Syrmaticus reevesii populations in 2018–2019 across its distribution range in central China to quantify the distribution of habitat suitable for this species. Our goal was to ascertain the current distribution of Reeves’s Pheasant and then identify the gaps in protecting Reeves’s Pheasant of the existing national nature reserve (NNR) network to provide suggestions for improving the conservation of this important species. The existing NNR network encompassed only 17.0% of the habitat suitable for Reeves’s Pheasant. Based on the current distributions of both suitable habitat and NNRs for Reeves’s Pheasant, we suggest most currently unprotected areas comprised moderately suitable habitat for species and should be prioritized in the future. A multiple species approach using Reeves’s Pheasant as a flagship species should be considered to understand the extent of mismatch between the distributions of protected areas and suitable habitat to improve the management effectiveness of NNRs. This case study provides an example of how the development of a conservation reserve network may be based on species distribution and habitat assessments and is useful to conservation efforts in other regions and for other species.
Modeling the Impacts of Venture Capital Investment on Firm Innovation

Taking firms listed on the Chinese Growth Enterprise Market (GEM) in 2008–2017 as the sample, this study investigates the impact of venture capital (VC) investment on Chinese firm innovation using propensity score matching and a difference-in-differences (PSM-DID) model. The results show that, overall, firms’ innovation inputs and outputs do not show obvious enhancement due to VC entry, but instead show a strong and then weak inhibitory effect. VCs have heterogeneous impacts on firm innovation; that is, compared to other types of firms, firms with technology-dependent characteristics and firms whose actual controllers are experts in the same industry can effectively mitigate the adverse impact of VC on innovation inputs and gradually promote growth in the quantity and quality of the innovation outputs after the second year of VC entry. This study not only reveals the impact of VC on firm innovation activities in the Chinese capital market but also provides empirical evidence to help improve the financial innovation service system and the use of the capital market to promote innovation in China.
Genetic and Phenotypic Attributes of Splenic Marginal Zone Lymphoma.

Splenic marginal zone B-cell lymphoma (SMZL) is a heterogeneous clinico-biological entity. The clinical course is variable, multiple genes are mutated with no unifying mechanism, essential regulatory pathways and surrounding microenvironments are diverse. We sought to clarify the heterogeneity of SMZL by resolving different subgroups and their underlying genomic abnormalities, pathway signatures and microenvironment compositions to uncover biomarkers and therapeutic vulnerabilities. We studied 303 SMZL spleen samples collected through the IELSG46 multicenter, international study (NCT02945319) by using a multiplatform approach. We carried out genetic and phenotypic analyses, defined self-organized signatures, validated the findings in independent primary tumor meta-data and in genetically modified mouse models, and determined correlations with outcome data. We identified two prominent genetic clusters in SMZL, termed NNK (58% of cases, harboring NF-κB, NOTCH and KLF2 modules) and DMT (32% of cases, with DNA-damage response, MAPK and TLR modules). Genetic aberrations in multiple genes as well as cytogenetic and immunogenetic features distinguished NNK- from DMT-SMZLs. These genetic clusters not only have distinct underpinning biology, as judged by differences in gene-expression signatures, but also different outcome, with inferior survival in NNK-SMZLs. Digital cytometry and in situ profiling segregated two basic types of SMZL immune microenvironments termed immune-suppressive SMZL (50% of cases, associated with inflammatory cells and immune checkpoint activation) and immune-silent SMZL (50% of cases, associated with an immune-excluded phenotype) with distinct mutational and clinical connotations. In summary, we propose a nosology of SMZL that can implement its classification and also aid in the development of rationally targeted treatments.
Kullanılabilirlik Sezgiselleri ile Problemlerinin İlişkilendirilmesi: Makine Öğrenmesi Kullanımı

Usability is an important factor showing that how user-friendly user interfaces are and it has a significant impact on customer satisfaction and brand loyalty. For this reason, many methods have been developed to identify usability problems during the design, development, * Sorumlu Yazar: İstanbul Teknik Üniversitesi, İşletme Fakültesi, Endüstri Mühendisliği Bölümü, İstanbul, Türkiye, ORCID: 0000-0001-9329-6936,
Aprendizagem e gestão de práticas eco-inovadoras: um estudo de caso em uma Associação de Reciclagem

Esse artigo objetiva descrever as práticas de gestão em uma associação de reciclagem, enfatizando, nesse processo, as práticas eco-inovadoras. A compreensão das práticas de gestão em uma associação de reciclagem traz contribuições ao estudo das práticas, pois os próprios associados trabalham e gerenciam o empreendimento. O entendimento das práticas eco-inovadoras colabora para que os atores produzam e reproduzam as práticas de gestão ambiental no campo. Para compreender como ocorrem e se efetivam essas práticas, utilizou-se observação direita e participação da pesquisadora em campo, bem como a leitura qualitativa dos dados, captados no decorrer do ano de 2017. A pesquisa contribui para revelar as práticas de gestão e de eco-inovação no ambiente associativista. Os resultados mostram que a associação é um local de conhecimento e desenvolvimento de práticas, que além de garantirem a sobrevivência de seus integrantes, alcançam resultados relevantes do ponto de vista ambiental.
Hand Detection for Safety to Avoid Accidents

Detecting the hand when it crosses the safety level and in return it also raises an alert in the form of alarm. So that the threat can be identified and proper measures are taken to overcome that. The methodology of the project goes as follows, taking input from camera , Image processing to detect hand, Projecting a line using computer vision, Raising alarm when hand crosses this projected safety line. The real time data is taken from the camera as an input to the Image processing algorithm. Then this input is processed to find the hand in image in it and checks whether the hand is crossing that safety line. If that hand is crossing the safety line we can simply raise alarm. The applications of the project are to the Employees who are working at industry are pushing the material into shredder machine. But somehow while pushing these material into shredder machine the employees are pushing their hands itself in the flow of work and the hands of employees were cut in that cause. So from a certain distance from shredder machine input we project a imaginary line using computer vision, So that if any hand crossing that imaginary line which is for safety we will raise an alarm. In addition, we can also extend the applications, by just replacing hand with the Bike, we can detect the bike, which is crossing the staggered stop line, and we can punish or fine them. As a part of object detection we are using Single short multibox detector.
Recent progress on novel current collector electrodes for energy storage devices: Supercapacitors

Current collectors play a very crucial role in the performance of an energy storage device. Regarding supercapacitors, material design, processing, and current collectors' surface properties can result in substantial variation in energy density, power output, cyclic charge–discharge behavior, and other key performance parameters. Most of the reviews in supercapacitor materials and devices focus on the synthesis, characterization, and electrochemical properties of electrode materials. In the present report, the recent advances in supercapacitor electrodes in conjunction with current collector materials and design are summarized in light of various supercapacitor devices categorized concerning their applications and working mechanisms. It includes the literature documented on multifarious supercapacitors, that is, flow supercapacitors, alternating current line filtering supercapacitors, redox electrolyte‐enhanced supercapacitor, metal ion hybrid supercapacitors, microsupercapacitors, electrochromic supercapacitors, and self‐healing supercapacitors. To the best of authors' knowledge, this is a new and recent summarized report on the development of current collector materials based on intended applications and the working principles of supercapacitors.
Ethics in financial planning: Analysis of ombudsman decisions using codes of ethics and fiduciary duty standards

Scandals show that ethics is an important topic in financial planning. Our research analyses 212 financial ombudsman decisions (2013–2018) to understand the nature of financial planning misconduct in complaint decisions. We develop a coding structure to ascertain what professional conduct involves and then use content analysis and cluster analysis to identify the aspects of professional conduct occurring in these misconduct decisions. Diligence, acting in the client’s best interest and having no reasonable basis for advice are interconnected elements in over half of these decisions. Secondary elements are misleading statements, conflicts of interest and disclosure. Analysis of decisions involving fiduciary duty showed that financial planners failed to ascertain a client’s circumstances and did not form advice based on their client’s information. As financial planning professionalises, future research, financial planning education, policy and practice should address these issues. JEL Classification: D14, G20, G50
Assessing the Effects of the COVID-19 Pandemic on Nontraditional Students’ Mental Health and Well-Being

The current study sought to measure how the COVID-19 pandemic affected the mental health and well-being of college students, particularly nontraditional students. Participants (n = 321) completed a series of surveys assessing their level of depression, anxiety, sleep disturbances, insomnia, and well-being. Participants also indicated their nontraditional student characteristics, level of resilience, and additional life stressors due to the pandemic. Statistical analyses found that participants reported higher levels of depression, anxiety, sleep disturbances, and insomnia, with corresponding lower levels of well-being across all students, compared with prepandemic levels. Results showed that while nontraditional students indicated an increased number of life stressors during the pandemic compared with their traditional peers, nontraditional students also demonstrated higher levels of resilience. Nontraditional students appear to be more successful at managing stressful life events due to the increased resilience that comes with age and experience, which can better prepare them to persevere and overcome challenges.
A Fluorogenic Labeling of Live Viruses

Viruses are an important class of pathogens that can cause serious infectious diseases. The ability to directly analyze viral particles in real time is essential to understand their pathological functions. In this work, we developed a strategy for fluorogenic labeling of live viruses by using an optimal tetrazolate-functionalized AIEgen (Aggregation-induced emission luminogen), named PBET. Due to its AIE activities, this dye fluoresces weakly when dissolved in aqueous solution, thus providing dark fluorescence background. The fluorescence turn-on labeling is achieved by binding of PBET molecules into the outmost viral proteins (e.g., structural Capsid protein VP1), which triggers protein-induced fluorescence enhancement (PIFE) of PBET. Probably due to this PIFE/AIE-based sensing strategy, these PBET-labeled viruses can retain infectivity to a large extent, which is a great advantage for biologically friendly labeling. This fluorogenic labeling may find uses in imaging studies to combat virus-associated infectious diseases, especially those associated with previously unknown wild-type viruses.
Quantitative Thermal Emission Spectroscopy at High Temperatures: A Laboratory Approach for Measurement and Calibration

Acquiring accurate high temperature laboratory‐based infrared emission spectra of geologic samples is important to constrain their radiative and spectral properties. This is important in calculations of lava flow cooling, crust formation, and ultimately lava flow propagation modeling. However, measuring accurate emission at high temperatures remains a challenge. A new micro‐furnace design was created to integrate with a Fourier transform infrared spectrometer, replacing the previous furnace and improving the performance and error metrics. Importantly, this approach accounts for all significant error sources and uses only one spectrometer to acquire sample and calibration emission data over greater temperature (473–1,573 K) and spectral (4,000–500 cm−1, 2.5–20 μm) ranges. Emissivity spectra of forsterite and quartz samples were acquired to test the calibration procedure. Forsterite, with no expected phase transitions over the temperature range, showed spectral change above ∼1140 K, potentially due to amorphization–a process not well described in past studies. The quartz results revealed the expected polymorph transformations at ∼846 and ∼1323 K. A Hawaiian basalt sample served as a representative rock test and showed an increase in emissivity (∼25%) with decreasing temperature. The greatest emissivity increase (∼60%) occurred in the middle infrared region (3,333–2,000 cm−1, 3–5 μm). This is significant for thermal/mass flux calculations using satellite data in this spectral region, which rely on emissivity to derive accurate temperatures. All results are consistent with our previous investigations, but with improved mean accuracy (<2%), uncertainty (<4%), and spectral contrast (<20%). The improved metrics were achieved by constraining the sample measurement geometry, sample temperature stability, and environmental contamination within the experiment.
The Digital Heritage of Covid-19 's Governance: How to Upgrade and Use the "Health Code" in the Post-Epidemic Era

The outbreak of Covid-19 accelerated the practice of digital survival, and the "health code" launched based on the needs of epidemic prevention and control has become the representative of digital survival media, which is jointly built by science and technology enterprises and government departments. it has realized the full-state use in China, and accumulated long-term digital survival experience for the country, enterprises and individuals. At the same time, there are some media ethical problems in the use of Health Code, such as distinguishing users, leaking information, imprisoning the body and leading to the lack of subjects. In order to resolve the risk, we should re-examine the relationship between people and the media from the perspective of the subject, treat "health code" as a digital projection of personal health, and regain the service principle of digital technology. Humanize the "health code" and other digital media.
“This Is Just What We Do”: PhD Students on Becoming Scholars in a Community of Practice

Increasingly librarians are interested in how the community of practice (CoP) framework can provide a more complete picture of how information literacy practices are influenced by situated and social learning. Doctoral students are socialized into the practices of the academy and gradually take on the identity and work of a scholar in their field. As an illustration of the CoP framework among doctoral students, the author shares data from a qualitative study with a small group of early-career education PhD students who are developing their information literacy skills within their disciplinary and social contexts, using the CoP as a source of support and reflection around their identity development as scholarly researchers and writers. Using critical reflection, the author considers the role of a librarian-researcher in an existing CoP of doctoral students and what role librarians can play in supporting students’ research and writing practices within the community.