Miracle-dz/UniFAR-FTUs huggingface dataset:
Institutional Knowledge at Singapore Management University When Peculiarity Makes a Difference: Object Characterisation in Heterogeneous Information Networks

A central task in heterogeneous information networks (HIN) is how to characterise an entity, which underlies a wide range of applications such as similarity search, entity proﬁling and linkage. Most existing work focus on using the main features common to all. While this approach makes sense in settings where commonality is of primary interest, there are many scenarios as important where uncommon and discriminative features are more useful. To address the problem, a novel model COHIN (Characterize Objects in Heterogeneous Information Networks) is proposed, where each object is characterized as a set of feature paths that contain both main and discriminative features. In addition, we develop an eﬀective pruning strategy to achieve greater query performance. Extensive experiments on real datasets demonstrate that our proposed model can achieve high performance.
TGF- β suppresses the activation of CD8 + T cells when naïve but promotes their survival and function once antigen-experienced: a two-faced impact on autoimmunity

Objective: TGF- β can exhibit strong immune suppression but has also been shown to promote T cell growth. We investigated the differential effect of this cytokine on CD8 + T cells in autoimmunity and antiviral immunity. Research Design and Methods: We used mouse models for virally induced type 1 diabetes (T1D) in conjunction with transgenic systems enabling manipulation of TGF- β expression or signaling in vivo . Results: Surprisingly, when expressed selectively in the pancreas TGF- β reduced apoptosis of differentiated autoreactive CD8 + T cells, favoring their expansion and infiltration of the islets. These results pointed to drastically opposite roles of TGF- β on naïve compared antigen-experienced/memory CD8 + T cells. Indeed, in the absence of functional TGF- β signaling in T cells fast-onset T1D caused by activation of naïve CD8 + T cells occurred faster, while slow-onset disease depending on accumulation and activation of antigen-experienced/memory CD8 + T cells was decreased. TGF- β receptor-deficient CD8 + T cells showed enhanced activation and expansion after LCMV infection in vivo but were more prone to apoptosis once antigen-experienced and failed to survive as functional memory cells. In vitro , TGF- β suppressed naïve CD8 + T cell activation and IFN- γ production, whereas memory CD8 + T cells stimulated in the presence of TGF- β showed enhanced survival and increased production of IL-17 in conjunction with IFN- γ . Conclusions: The effect of TGF- β on CD8 + T cells is dependent on their differentiation status and activation history. These results highlight a novel aspect of the pleiotropic nature of TGF- β and have implications for the design of immune therapies involving this cytokine. lymph nodes (PDLN) of mice fed a dox-free diet. The frequency of NP118-specific/responsive CD8 + T cells was evaluated in pooled pancreata (3-4 mice) by tetramer staining and in the spleen and PDLN by flow cytometry after stimulation with NP118 ex vivo .
The helium-to-hydrogen ratio of the UV-bright star Barnard 29 of Messier 13

Barnard 29 is the most luminous UV-bright star of the globular cluster Messier 13. Comparison of its reddening corrected optical region spectrophotometry and IUE low dispersion fluxes and its H-gamma profile with the predictions of metal-poor model atmospheres having the metallicity of M 13 indicated T(sub eff) = 20250 K, log g = 3.15. Observations of He I lambda(4026) taken with echelle spectrograph of the Multi-Mirror telescope using a Reticon detector show that He/H = 0.055 +/- 0.020. Some astrophysical implications of this result are discussed.
Towards Improvement in Free Throw Skills by the Means of Virtual Reality

This paper presents the implementation of a gaming simulator that would provide the users with feedback which could help them to improve their skills. The game of basketball was chosen both because it is currently one of the most popular sports and because there aren’t similar implementations that aim for free throw skills training. Key elements of a projectile trajectory from launch to landing and possible collisions were studied in order to create an immersive application that could give the user the feeling of realism. Following, we will describe the architecture of the simulator, the provided feedback and we will also present some conclusions regarding to the applicability of this tool with additions like collisions and accelerated trajectory module in training human sport skills.
"Cognitive Network Fault Management Approach for Improving Resilience in 5G Networks

—Resilience is one of the fundamental requirements of critical communication services such as ultra-reliable low latency (URLLC) services offered by 5G networks. In order to support the communication service, the 5G networks can take different approaches for deployment of network functions, i.e. the network functions can run on virtualized infrastructure (telco cloud) as well as on the specialized physical hardware instances (e.g. RAN functions). Irrespective of the deployment approach taken the adequate level of resilience needs to be supported on all parts of the network in order to achieve required level of service resilience. In this work, we aim at improving the resilience level of communication services by applying network fault management techniques specialized for 5G slicing-enabled networks taking jointly into account the aspects of virtualized and physical infrastructure. We describe the novel approach of designing ﬂexible and cognitive fault management functions that can dynamically adapt their behavior based on the actual network slice requirements and current network context. We highlight the beneﬁts of such an approach in achieving the required level of resilience especially addressing the telco cloud domain.
Numerical Modeling and Simulation of an Underwater Explosion Bubble

Submitted for the DFD05 Meeting of The American Physical Society Numerical Modeling and Simulation of an Underwater Explosion Bubble RANDY S. LAGUMBAY, THOMAS L. GEERS, OLEG V. VASILYEV, University of Colorado at Boulder — Two representative single-degree-of-freedom models for the dilation of an oscillating bubble are assessed. One, by Keller and Kolodner (K&K), includes energy loss associated with external acoustic waves; the other, by Geers and Hunter (G&H), includes energy loss associated with both external and internal acoustic waves. In the evaluation, the spherically symmetric Euler equations for adiabatic conditions are expressed over a mapped space that explicitly defines the gas-liquid interface, and are then solved numerically. The details of the numerical method are given and spatial and temporal evolution of pressure and velocity fields, together with evolution of bubble radius are presented. The results for the transient solution demonstrate the wave nature of the phenomena as well as point out to the challenges posed by this seemingly straightforward problem. The results obtained lie between those produced by the K&K and G&H models, demonstrating that the former underestimates acoustic energy loss while the latter overestimates it. A comparison with experimental data shows total energy loss to be greater than that predicted even by the G&H model, which points to the role played by non-acoustic loss mechanisms. Randy S. Lagumbay University of Colorado at Boulder Date submitted: 03 Aug 2005 Electronic form version 1.4
ENFLURANE-INDUCED BURST FIRING OF HIPPOCAMPAL CA 1 NEURONES a Preparation

EEG activation and seizure activity can be produced by cyclopropane (Mori, 1973), ether (Joas and Eger, 1971), ketamine (Bowyer and Winters, 1981) and enflurane (Black, 1979; Steen and Michenfelder, 1979). Of these, enflurane is the only agent in clinical use which produces seizure activity during anaesthesia (Persson, Peterson and Wahlin, 1978); it exibits a profile of excitatory and depressant CNS effects similar to those of phencyclidine, gamma-hydroxybutyrate, and alpha-chloralose (Winters, 1982). The convulsive actions of enflurane may result from excitation or depression, or both, in the CNS, since both have been observed during enflurane anaesthesia (Darimont and Jenkins, 1977; Steen and Michenfelder, 1979). Although the neurophysiological basis of anaesthetic-induced excitatory and convulsant effects is unknown, it is unlikely that a simple depression of neuronal excitability or synaptic transmission could account for all of the pharmacological actions of these agents (Roth, 1980; Richards, 1983).
SQRM: An Effective Solution to Suspicious Users in Database

—Since traditional database mechanisms such as identity authentication and access control, can be fooled by authorized but malicious users, to solving the problems, three key techniques namely intrusion detection, damage quarantine and recovery are studied for decades to implement survival database systems. However, these techniques are all built on identification of malicious behaviors, which is much more complex, sluggish and inefficient than the identification of suspicious behaviors because the former need more evidence than the later. This paper proposes an effective security mechanism by focusing suspicious users, namely suspect quarantine and recovery method denoted as SQRM, to increase the attack resistance of databases. It isolates invalid data transparently from trustworthy users to prevent further damage by suspicious users suspected to be malicious, while still maintaining continued availability for their data access operations to minimize loss of productive work in the case of incidents that they are indeed innocent. And when they are proved innocent or malicious, all invalid data caused by them will be concurrently recovered. Using SQRM is sufficiently effective to improve the survivability for database.
CCID_A_310426 437..453

Department of Dermatology, The First Affiliated Hospital of Hunan Normal University/Hunan Provincial People’s Hospital, Changsha, People’s Republic of China Purpose: This study was meant to analyze immune infiltration and construct a ceRNA network to explore the new therapeutic targets for atopic dermatitis (AD) through bioinformatics way. Patients and Methods: We downloaded the AD patients’ RNA expression profile datasets (GSE63741, GSE124700) from the Gene Expression Omnibus (GEO) database, which were analyzed through the GEO2R. We explored the hub genes by the enrichment analysis and the protein–protein interaction (PPI) analysis. Moreover, we estimated immune cell types and their proportions by ImmucellAI. GSE121212 dataset validation was performed to verify the robustness of the hub genes. Then, a ceRNA network was constructed by the miRWalk, miRNet, miRDB, DIANA, TargetScan, and starbase database. Finally, gene expression analysis was performed by using RT-qPCR. Results: In total, we detected 22 differentially expressed genes (DEGs), which contained 8 downregulated genes and 14 upregulated genes. There were 5 hub genes confirmed as key genes through PPI network analysis and the ROC curves. KEGG pathway analysis revealed that they were significantly enriched in the IL-17 signaling pathway and GO analysis showed mainly in the immune cell chemotaxis. The immune infiltration profiles were different between normal controls and AD, and each of the key genes (S100A7, S100A8, S100A9, and LCE3D) was significantly correlated with the main infiltration cell of AD. A lncRNA–miRNA–mRNA ceRNA network containing the key genes was constructed, and NEAT1 and XIST, the core of ceRNA network, were significantly overexpressing verified by RT-qPCR in AD patients. Conclusion: Altogether, the key genes and their ceRNA network provided a novel perspective to the immunomodulation of AD, which may be potential and new therapeutic targets for AD.
STUDY TO KNOW THE PREVELANCE OF DEFICIENCY OF VITAMIN D IN PATIENTS PRESENTING WITH OSTEOARTHRITIS

: Objective: Osteoarthritis (OA) is a major public health issue that causes chronic pain and disability although at present the pathogenesis of this condition remains largely unknown. Several environmental factors have been associated with OA, including obesity previous injury knee-bending occupations and other metabolic factors. To measure the frequency of Vitamin D deficiency in those patients who are presenting with osteoarthritis in a tertiary healthcare unit. Study Design: cross sectional (single center) study study Medicine at Pakistan Institute of Medical January 2020. Materials and Methods: Two hundred osteoarthritis patients were put into the inclusion criteria of this study. Then venous blood sample of each patient was obtained by using 5cc BD syringe. Samples were then sent to the hospital`s laboratory for assessment of level of vitamin D in blood. All procedures were noted on proforma. Results: The mean age of the respondents came out to be 57.57±9.91 years. There were 121(60.5%) male and 79(39.5%) female. Vitamin D deficiency`s frequency in patients presenting with osteoarthritis was observed in 56% (112/200) patients. Conclusion: High percentage of deficiency of vitamin D was revealed. Vitamin D deficiency`s frequency increased significantly with increasing age and was found to be greater in female patients. It is needed to take instant measures for tackling this increasing public health issue.
Application of weighted moments to image coding, decoding and processing. Part I. Reconstruction of an image from its weighted moments*

The concept of a certain class of optical image digital representations presented in this paper is based on weighted optical moments. The current state of investigations on such nonorthogonal representations is reported. The optimal reconstruction pro­ cedure is given for the general case. The reconstruction-accuracy improvement by means of approximation based on Chebyshev polynomials is presented.
“Flexible vs. robust lot scheduling subject to random production yield and deterministic dynamic demand” by

aDepartment of Production Management Leibniz Universität Hannover Königsworther Platz 1 D-30167 Hannover, Germany stefan.helber@prod.uni-hannover.de, +49 511 7625650 bFaculty of Economics and Management Otto-von-Guericke Universität Magdeburg Universitätsplatz 2 karl.inderfurth@ovgu.de cDepartment of Production and Industrial Management Technische Universität Chemnitz Thüringer Weg 7 D-09126 Chemnitz, Germany florian.sahling@wirtschaft.tu-chemnitz.de, +49 371 531-31130 dDepartment of Procurement and Production Universität Hohenheim Schloss Osthof Nord Schwertzstr. 40 D-70599 Hohenheim, Germany katja.schimmelpfeng@uni-hohenheim.de, +49 711 459 23358 eCorresponding author
ACETYLATION OF LYSINE 564 ADJACENT TO THE CTBP-BINDING MOTIF IN EVI1 IS CRUCIAL FOR TRANSCRIPTIONAL ACTIVATION OF GATA2

were transfected into COS7 cells, and protein complexes containing P/CAF were precipitated by anti-P/CAF antibodies. Precipitated proteins were detected by anti-EVI1, P/CAF or CtBP antibodies. Stars indicate nonspecific bands. B , After transfection with four kinds of expression vectors (EVI1, P/CAF, CtBP2, or HDAC1), formalin-fixed DNA fragments were immunoprecipitated with anti-EVI1, anti-P/CAF, anti-CtBP2, or anti-HDAC1 antibody. After immunoprecipitation, purified DNA was amplified by specific pairs of primers in the GATA2 promoter region. Each species-specific IgG was used for immunoprecipitation as an isotype control. C , Loss of GATA2 transcriptional activation by transfection with an EVI1-K564A mutant. EVI1 or EVI1-K564A mutant expression vectors were transfected into COS7 cells either with CtBP2 alone or CtBP2 with P/CAF expression vectors for luciferase assays of GATA2 promoter activity. GATA2 transfection the lysine-mutated EVI1 vector. After transfection with mutants GATA2 control Then, using specific EVI1 binding E , P/CAF EVI1 EVI1 GATA2 After co-transfection EVI1 CtBP2 control F, Gel-mobility shift assay EVI1 or EVI1-K564A mutant expression vectors into COS7 cells, EVI1 purified by anti-FLAG M2 antibody was used for GMSA with EVI1 binding oligonucleotides specific for D1/b or D2/i. Purified EVI1 protein was detected with anti-FLAG-M2 antibody, and a 100-fold excess of cold binding oligonucleotides (D1/b or D2/i) was added to the GMSA reaction. G , Levels of EVI1, P/CAF and GATA2 were determined in UCSD/AML1 cells during shP/CAF expression by semi-quantitative RT-PCR. UCSD/AML1 cells with an shLuc expression vector were used as a control. H, Levels of P/CAF, EVI1 acetylation at Lys 564 , and EVI1 were determined by immunoblot using each specific antibody with b-actin as a control in both UCSD/AML1 cells with shLuc and with shP/CAF. I, Chromatin-immunoprecipitation analysis of the EVI1 binding site in the GATA2 promoter region after transfection of shP/CAF or shLuc expression vectors into UCSD/AML1 cells. DNA was precipitated with an anti-EVI1 antibody or control mouse IgG.
Production of type I interferons

Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs) that respond to most viruses. Because of their antiviral activity and regulatory functions in innate and adaptive immunity, type I IFNs are important not only for antiviral resistance but also in other types of infections and in immune pathology. Here we discuss recent data that begin to reveal the unique molecular mechanisms underlying the remarkably rapid and efficient type I IFN production by pDCs.
Future of Performance Management in Artificial Intelligence ERA

Talent resource is considered as a crucial asset for the sustainable development of the collaborative, digitized high performance organisations in this globalized era. Companies are increasingly making an effort to face the challenge of how to make performance management a success within the organisation. Traditionally, performance management system is focused on annual appraisals as the measure of employee’s progress. Information technology, big data analytics and artificial intelligence have changed the way management measures employee performance. To achieve competency benchmarks companies have realised the importance of artificial intelligence in performance management system. The quality of employee performance invariably improves due to integration of advanced technologies like machine learning and artificial intelligence that enables the adoption of predictive analytics in accentuating employee performance. The study has significant practical implication on organisational performance management practices, employee performance and employees engagement context in modern organizations through increased productivity, involvement, creation of trust in leadership, supportive management, reduce absenteeism and employee turnover. Digital performance management system will reduce the time, efforts of management and lead to transparency and honesty in employee performance appraisal. The outcome of study is to know the practical applicability of performance management system. The methodology used to study is conceptual research. This study aims to highlight the future of Performance Management system in artificial intelligence era and Performance management methods practiced in modern high performance organisations, posit a conceptual model, and provide a critical view in global enterprise to understand and improve Performance appraisal.
Spin noise of conduction electrons in n -type bulk GaAs

We report a comprehensive study of stochastic electron spin fluctuations -- spin noise -- in lightly doped ($n$-type) bulk GaAs, which are measured using sensitive optical magnetometry based on off-resonant Faraday rotation. Frequency spectra of electron spin noise are studied as a function of electron density, magnetic field, temperature, probe laser wavelength and intensity, and interaction volume. Electron spin lifetimes $\tau_s$ are inferred from the width of the spin noise spectra, and are compared with direct measurements of $\tau_s$ using conventional Hanle effect methods. Both methods reveal a strong and similar dependence of $\tau_s$ on the wavelength and intensity of the probe laser, highlighting the undesired influence of sub-bandgap absorption effects on the nominally `non-perturbative' spin noise measurements. As a function of temperature, the spin noise power increases approximately linearly from 1.5 K to 30 K, as expected for degenerate electrons obeying Fermi-Dirac statistics, but with an additional zero-temperature offset. Finally, as the cross-sectional area of the probe laser shrinks and fewer electrons are probed, the measured Faraday rotation fluctuations due to electron spin noise are shown to increase, as expected.
Neutrino Oscillations and Entanglement

An improved treatment of neutrino oscillations follows when neutrino mass eigenstates and their associated recoiling particle states are entangled. When the neutrino and its recoil partner are treated as a single entangled quantum state the conservation of energy and momentum in neutrino oscillations can be assured, even in a plane-wave treatment. The oscillation wavelength between the neutrino and its associated recoil partner emerges as the fundamental periodicity in this analysis. However, the experimentally determined oscillation wavelength for neutrinos detected at some distance from a known source region is still in all cases given by the standard expression in current use.
Houdmont, Jonathan and Madgwick, P. and Randall, R. (2016) Sun safety in construction: a UK intervention

Background: Interventions to promote sun safety in the UK construction sector are warranted given the high incidence of skin cancer attributable to sun exposure relative to other occupational groups. Aims: To evaluate change in sun safety knowledge and practices among construction workers in response to an educational intervention. Methods: A baseline questionnaire was administered, followed by a bespoke sector-specific DVD-based intervention. At 12-month follow-up participants completed a further questionnaire. Results: Analyses were conducted on a sample of 120 workers (intervention group, n = 70; comparison group, n = 50). At follow-up the proportion of intervention group participants that reported correct sun safety knowledge was not significantly greater than at baseline. However, the intervention group demonstrated significant positive change on nine out of ten behavioural measures, the greatest change being use of a shade/cover when working in the sun followed by regularly checking skin for moles or unusual changes. Conclusions: Exposure to this intervention was linked to some specific positive changes in construction workers’ self-reported sun safety practices. These findings highlight the potential for educational interventions to contribute to tackling skin cancer in the UK construction sector. The findings support the development of bespoke educational interventions for other high-risk outdoor worker groups.