Miracle-dz/UniFAR-FTUs huggingface dataset:
Far from home: the role of glial mRNA localization in synaptic plasticity

Neurons and glia are highly polarized cells, whose distal cytoplasmic functional subdomains require specific proteins. Neurons have axonal and dendritic cytoplasmic extensions containing synapses whose plasticity is regulated efficiently by mRNA transport and localized translation. The principles behind these mechanisms are equally attractive for explaining rapid local regulation of distal glial cytoplasmic projections, independent of their cell nucleus. However, in contrast to neurons, mRNA localization has received little experimental attention in glia. Nevertheless, there are many functionally diverse glial subtypes containing extensive networks of long cytoplasmic projections with likely localized regulation that influence neurons and their synapses. Moreover, glia have many other neuron-like properties, including electrical activity, secretion of gliotransmitters and calcium signaling, influencing, for example, synaptic transmission, plasticity and axon pruning. Here, we review previous studies concerning glial transcripts with important roles in influencing synaptic plasticity, focusing on a few cases involving localized translation. We discuss a variety of important questions about mRNA transport and localized translation in glia that remain to be addressed, using cutting-edge tools already available for neurons.
Efficient Inverted Perovskite Solar Cells via Improved Sequential Deposition

Inverted‐structure metal halide perovskite solar cells (PSCs) have attractive advantages like low‐temperature processability and outstanding device stability. The two‐step sequential deposition method shows the benefits of easy fabrication and decent performance repeatability. Nevertheless, it is still challenging to achieve high‐performance inverted PSCs with similar or equal power conversion efficiencies (PCEs) compared to the regular‐structure counterparts via this deposition method. Here, an improved two‐step sequential deposition technique is demonstrated via treating the bottom organic hole‐selective layer with the binary modulation system composed of a polyelectrolyte and an ammonium salt. Such improved sequential deposition method leads to the spontaneous refinement of up and buried interfaces for the perovskite films, contributing to high film quality with significantly reduced defect density and better charge transportation. As a result, the optimized PSCs show a large enhancement in the open‐circuit voltage by 100 mV and a dramatic lift in the PCE from 18.1% to 23.4%, delivering the current state‐of‐the‐art performances for inverted PSCs. Moreover, good operational and thermal stability is achieved upon the improved inverted PSCs. This innovative strategy helps gain a deeper insight into the perovskite crystal growth and defect modulation in the inverted PSCs based on the two‐step sequential deposition method.
Low‐frequency noise in dc superconducting quantum interference devices below 1 K

At temperatures below about 1 K, a series of dc superconducting quantum interference devices (SQUID’s) exhibited an apparent flux noise with a spectral density scaling as 1/f α, where 0.58<α<0.80. Typically, the magnitude of the noise increased as the temperature was lowered below 1 K, tending to flatten out at low temperatures with a value of 7±3 μΦ0Hz−1/2 at 1 Hz that was nearly independent of the parameters and materials of the SQUID’s. Although a large number of hypothetical sources of the noise have been eliminated, the origin remains unidentified.
Optical properties of metallic nanoparticle arrays on a thin metallic film

We consider the optical properties of a periodic array of silver spherical particles with diameters of a few hundred nanometers on top of a thin Ag film. Maxwell’s equations are solved using a multiple-scattering formalism which combines high accuracy with efficiency. We study the interaction between flat-surface and localized particle plasmons. Interestingly, the presence of a periodic array can lead to an enhanced transmission through the metallic film due to leakage of the surface plasmon-polaritons in the substrate.
A core microbiome in the hyphosphere of arbuscular mycorrhizal fungi has functional significance in organic phosphorus mineralization.

The mycorrhizal pathway is an important phosphorus (P) uptake pathway for more than two thirds of land plants. The arbuscular mycorrhizal (AM) fungi associated hyphosphere microbiome has been considered as the second genome of mycorrhizal P uptake pathway and functionality in mobilizing soil organic P (Po). However, whether there is a core microbiome in the hyphosphere and how this is implicated in mining soil Po are less understood. We established on-site field trials located in humid, semiarid and arid zones and a microcosm experiment in a greenhouse with specific AM fungi and varying soil types to answer the above questions. The hyphosphere microbiome of AM fungi enhanced soil phosphatase activity and promoted Po mineralization in all sites. Although the assemblage of hyphosphere microbiomes identified in three climate zones was mediated by environmental factors, we detected a core set in three sites and the subsequent microcosm experiment. The core members were co-enriched in the hyphosphere and dominated by Alphaproteobacteria, Actinobacteria, and Gammaproteobacteria. Moreover, these core bacterial members aggregate into stable guilds that contributed to phosphatase activity. The core hyphosphere microbiome is taxonomically conserved and provide functions, with respect to the mineralization of Po, that AM fungi lack.
Critical review of thermoelectrics in modern power generation applications

The thermoelectric complementary effects have been discovered in the nineteenth century. However, their role in engineering applications has been very limited until the first half of the twentieth century, the beginning of space exploration era. Radioisotope thermoelectric generators have been the actual motive for the research community to develop efficient, reliable and advanced thermoelectrics. The efficiency of thermoelectric materials has been doubled several times during the past three decades. Nevertheless, there are numerous challenges to be resolved in order to develop thermoelectric systems for our modern applications. This paper discusses the recent advances in thermoelectric power systems and sheds the light on the main problematic concerns which confront contemporary research efforts in that field.
The earliest phases of massive star formation within entire molecular cloud complexes

We started (sub-)millimeter continuum and line studies of entire molecular cloud complexes located at intermediate distances from the Sun (1–3 kpc). Such an unbiased approach allows to identify and characterize the earliest phases of high-mass stars overlooked by IRAS or MSX. Our complete MAMBO-2 surveys of the Cygnus X and NGC 7538 complexes reveal a large population of ${\sim} 0.1$ pc-size massive young stellar objects (MYSOs) harboring high-mass infrared-quiet protostars. The determination of the nature of all the new millimeter sources is still in progress but we have already collected evidence that the infrared-quiet (or class 0-like) protostellar phase might last as long as the better-known infrared-bright protostellar phase. Besides, our complete census of MYSOs fails to discover the high-mass analogues of pre-stellar dense cores. We propose that the observed lower-density pre-stellar clumps (${>} 1$ pc) rapidly concentrate and collapse as also found in the kinematical studies of other prominent clumps. Indeed, CS and HCO$^+$ mappings in W43 and Cygnus X suggest global supersonic contraction with inward velocities of several km s−1 on parsec scales. Our work and similar studies of entire star-forming complexes will thus definitively contribute to a better knowledge of the earliest phases of high-mass star formation.
Visual Integration and Detection of Discontinuities: The Key Role of Intensity Edges

Integration of several vision modules is likely to be one of the keys to the power and robustness of the human visual system. We suggest that integration is best performed at the location of discontinuities in early processes, such as discontinuities in image brightness, depth, motion, texture, and color. Coupled Markov Random Field models can be used to combine vision modalities with their discontinuities. We derive a scheme to integrate intensity edges with stereo depth and motion field information and show results from a Connection Machine algorithm on synthetic and natural images. The use of intensity edges to integrate other visual cues and to help discover discontinuities emerges as a general and powerful principle.
Automatic calibration of low-cost digital cameras

Recent developments of digital cameras in terms of the size of charge-coupled device (CCD) arrays and reduced costs are leading to their applications in traditional as well as new photogrammetric, surveying, and mapping functions. Digital cameras, intended to replace conventional film-based mapping cameras, are becoming available along with many smaller formats capable of precise measurement applications. All such cameras require careful calibration to determine their metric characteristics, which are essential to carrying out photogrammetric activities. We introduce a new approach for incorporating straight lines in a bundle adjustment for calibrating off-the-shelf, low-cost digital cameras. The optimal configuration for successfully deriving the distortion parameters is considered when establishing the required test field. Moreover, a framework for automatic extraction of the straight lines in the images is presented and tested. The developed calibration procedure can be used as an efficient tool to investigate the most appropriate model that compensates for various distortions associated with the camera being calibrated. Experiments performed to compare line-based with traditional point-based self-calibration methods prove the feasibility of the suggested approach.
Ocular involvement in primary antiphospholipid syndrome: results of an extensive ophthalmological evaluation performed in the APS-Rio cohort

Objective To study ophthalmological manifestations in a well-characterized primary antiphospholipid syndrome (PAPS) cohort (APS-Rio) and compare them with a healthy control group. Methods We examined PAPS patients and controls with an extensive ophthalmological evaluation, which included anamnesis, visual acuity, slit-lamp biomicroscopy, binocular indirect ophthalmoscopy, and retinography of the anterior and posterior segments of the eye. PAPS group also underwent angiography exam and optical coherence tomography using spectral domain technology (SD-OCT). Results 98 PAPS patients and 102 controls were included. The most common symptom in PAPS was amaurosis fugax (34.7% vs. 6.9%; p = .001). In the multivariate analyses, Raynaud’s phenomenon was associated with amaurosis fugax (OR 3.71, CI:1.33–10.32; p = .012), and livedo correlated with hemianopia (OR 6.96, CI:1.11–43.72, p = .038) and diplopia (OR 3.49, CI:1.02–11.53, p = .047). After ophthalmological evaluation, 84 PAPS patients had ocular involvement (1.0% glaucoma, 94.0% posterior findings, 62.7% anterior findings, and 56.6% both posterior and anterior findings). Vascular tortuosity was more frequent in the PAPS group (63.2% vs. 42.2%; p = .002), as well as peripheral tortuosity (29.6% vs. 7.8%; p < .001). After excluding patients with atherosclerotic risk factors, peripheral vascular tortuosity was still statistically associated with PAPS (35.0 vs. 7.8%, p < .001). Triple positivity was more frequent in PAPS patients with peripheral vascular tortuosity than in those without this ocular finding (34.5% vs. 15.9%, p = .041). Conclusion Vasomotor phenomena are importantly related to ocular symptoms in PAPS. Vascular tortuosity was a frequent finding in PAPS patients. Peripheral vascular tortuosity was associated with triple positivity and might be a biomarker of ischemic microvascular retinopathy due to PAPS.
Oral vaccination of mice with attenuated Salmonella encoding Trichinella spiralis calreticulin and serine protease 1.1 confers protective immunity in BALB/c mice

Background Trichinella spiralis is a foodborne parasitic nematode which is a serious risk to meat safety. Development of anti-Trichinella vaccine is needed to control Trichinella infection in food animals. In this study, two novel T. spiralis genes (calreticulin and serine protease 1.1) in combination were used to construct oral DNA vaccines, and their induced protective immunity was evaluated in a murine model. Methodology/Principal findings TsCRT+TsSP1.1, TsCRT and TsSP1.1 DNA were transformed into attenuated Salmonella typhimurium ΔcyaSL1344. Oral vaccination of mice with TsCRT+TsSP1.1, TsCRT and TsSP1.1 DNA vaccines elicited a gut local mucosal sIgA response and systemic Th1/Th2 mixed response. Oral vaccination with TsCRT+TsSP1.1 induced obviously higher level of serum specific antibodies, mucosal sIgA and cellular immune response than either of single TsCRT or TsSP1.1 DNA vaccination. Oral vaccination of mice with TsCRT+TsSP1.1 exhibited a 53.4% reduction of enteral adult worms and a 46.05% reduction of muscle larvae, conferred a higher immune protection than either of individual TsCRT (44.28 and 42.46%) or TsSP1.1 DNA vaccine (35.43 and 29.29%) alone. Oral vaccination with TsCRT+TsSP1.1, TsCRT and TsSP1.1 also obviously ameliorated inflammation of intestinal mucosa and skeletal muscles of vaccinated mice after challenge. Conclusions TsCRT and TsSP1.1 might be regarded the novel potential targets for anti-Trichinella vaccines. Attenuated Salmonella-delivered DNA vaccine provided a prospective approach to control T. spiralis infection in food animals.
Measurement of CO overtone line profiles in SVS 13

High-resolution spectra of the CO overtone emission in the infrared source SVS 13 are obtained and the individual vibration-rotation lines are resolved for the first time in a young stellar object. The observed FWHM velocity of the lines in the v = 2-0 band is 40 km/s. A fit of the v = 2-0 band head with a single temperature LTE slab model yields an optical depth of 0.3 in the R(51) line and a rotational temperature of about 3500 K. Given the best estimates for the orientation of the SVS 13 outflow, the observed line widths are much smaller than expected for either of the two most favored interpretations for the CO emission: a circumstellar disk or a high-velocity neutral wind.
GAMaterial—A genetic‐algorithm software for material design and discovery

Genetic algorithms (GAs) are stochastic global search methods inspired by biological evolution. They have been used extensively in chemistry and materials science coupled with theoretical methods, ranging from force‐fields to high‐throughput first‐principles methods. The methodology allows an accurate and automated structural determination for molecules, atomic clusters, nanoparticles, and solid surfaces, fundamental to understanding chemical processes in catalysis and environmental sciences, for instance. In this work, we propose a new genetic algorithm software, GAMaterial, implemented in Python3.x, that performs global searches to elucidate the structures of atomic clusters, doped clusters or materials and atomic clusters on surfaces. For all these applications, it is possible to accelerate the GA search by using machine learning (ML), the ML@GA method, to build subsequent populations. Results for ML@GA applied for the dopant distributions in atomic clusters are presented. The GAMaterial software was applied for the automatic structural search for the Ti6O12 cluster, doping Al in Si11 (4Al@Si11) and Na10 supported on graphene (Na10@graphene), where DFTB calculations were used to sample the complex search surfaces with reasonably low computational cost. Finally, the global search by GA of the Mo8C4 cluster was considered, where DFT calculations were made with the deMon2k code, which is interfaced with GAMaterial.
A Study of Distance Metrics in Histogram Based Image Retrieval

There has been a profound expansion of digital data both in terms of quality and heterogeneity. Trivial searching techniques of images by using metadata, keywords or tags are not sufficient. Efficient Content-based Image Retrieval (CBIR) is certainly the only solution to this problem. Difference between colors of two images can be an important metric to measure their similarity or dissimilarity. Content-based Image Retrieval is all about generating signatures of images in database and comparing the signature of the query image with these stored signatures. Color histogram can be used as signature of an image and used to compare two images based on certain distance metric. In this study, COREL Database is used for an exhaustive study of various distance metrics on different color spaces. Euclidean distance, Manhattan distance, Histogram Intersection and Vector Cosine Angle distances are used to compare histograms in both RGB and HSV color spaces. So, a total of 8 distance metrics for comparison of images for the sake of CBIR are discussed in this work.
Molecular dynamics study reveals key disruptors of MEIG1–PACRG interaction

Interactions between the meiosis‐expressed gene 1 (MEIG1) and Parkin co‐regulated gene (PACRG) protein are critical in the formation of mature sperm cells. Targeting either MEIG1 or PACRG protein could be a contraceptive strategy. The W50A and Y68A mutations on MEIG1 are known to interrupt the MEIG1–PACRG interactions resulting in defective sperm cells. However, the details about how the mutants disrupt the protein–protein binding are not clear. In this study, we reveal insights on MEIG1 and PACRG protein dynamics by applying Gaussian‐accelerated molecular dynamics (GaMD) simulations and post‐GaMD analysis. Our results show that the mutations destabilize the protein–protein interfacial interaction. The effect of the Y68A mutation is more significant than W50A as Y68 forms stronger polar interactions with PACRG. Because both human and mouse models demonstrate similar dynamic properties, the findings from mouse proteins can be applied to the human system. Moreover, we report a potential ligand binding pocket on the MEIG1 and PACRG interaction surface that could be a target for future drug design to inhibit the MEIG1–PACRG interaction. PACRG shows more qualified pockets along the protein–protein interface, implying that it is a better target than MEIG1. Our work provides a fundamental understanding of MEIG1 and PACRG protein dynamics, paving the way for drug discovery in male‐based contraception.
Micronutrient intake and associated factors among school adolescent girls in Meshenti Town, Bahir Dar City Administration, Northwest Ethiopia, 2020

Background Adolescent girls have a greater nutrient demand and their poor dietary intake is associated with micronutrient deficiencies and poor maternal outcomes. Having information on micronutrient intake inadequacy in adolescent girls is critical for promoting healthy behavior and breaking the cycle of intergenerational malnutrition. Thus, this study assessed overall micronutrient intake inadequacy and associated factors among school adolescent girls in Meshenti town of Bahir Dar City Administration, North West Ethiopia. Methods A school-based cross-sectional study was conducted among 401 adolescent girls from February 7 to 23, 2020. A Simple random sampling technique was used to select study participants. A multiple-pass 24-hour dietary recall with portion size estimation method and recommended dietary allowance cut-off point were used to assess micronutrient intake inadequacy. Overall micronutrient intake inadequacy was measured using the mean adequacy ratio. Nutrient databases were developed by ESHA FOOD PROCESSOR version 8.1 software. Data were entered into Epi-data version 3.1 and exported to SPSS version 23 for analysis. Multivariable logistic regression was performed to identify determinants of overall micronutrient intake inadequacy and an adjusted odds ratio at a p-value of less than 0.05 was used to see the strength of statistical association. Results The prevalence of overall micronutrient intake inadequacy was 44.4% (95% CI: 39.7%-49.6%). Early adolescent age (AOR: 2.75, 95% CI: 1.71–4.42), food-insecure household (1.74, 95%CI: 1.087–2.784), low dietary diversity score (AOR = 2.83, 95% CI: 1.35–5.92), and high peer pressure on eating and body concern (AOR = 1.853, 95% CI: 1.201–2.857) were significantly associated factors with overall micronutrient intake inadequacy. Conclusion Findings of this study revealed that micronutrient intake inadequacy among adolescent girls was a high public health problem in the study area. Therefore, attention should be given to adolescent girls of the study area, especially the ones in the early adolescent age. Interventions should also focus on nutrition-sensitive activities to address food insecurity, a less diversified diet, and the negative impact of peer influence.
Effects of telehealth on functional capacity, mental health and quality of life among older people with dementia: LAPESI telehealth protocol for a randomized controlled trial.

BACKGROUND Telehealth can be an alternative action at a distance that can help as a form of motor intervention, alleviating the deleterious effects arising from social distancing on functional capacity, mental health and quality of life among older people with dementia during the COVID-19 pandemic. PURPOSE We aim to analyze the effects of a telehealth program on functional capacity, mental health and quality of life among older people with dementia and their caregivers. METHODS seventy-eight individuals with mild and moderate dementia and their caregivers will answer an anamnesis and be evaluated through Clinical Dementia Assessment Score. They will also be evaluated by blinded examiners in terms of functional capacity (Activities of Daily Living Questionnaire and World Health Organization Disability Assessment Schedule 2.0), mental health (Mini-Mental State Examination, Clock Drawing Test, Verbal Fluency test and the Neuropsychiatric Inventor) and quality of life (Quality of Life in Alzheimer's Disease scale). Afterward, the volunteers will be randomized into the telehealth training group and the control group. The TR will perform systematic physical and cognitive exercises in 50-min sessions three times a week with professional monitoring, while the CG will receive non-systematized guidance, both for 12 weeks. Participants will be evaluated at baseline, immediately after the three-month interventions and with a 12-week follow- up. DISCUSSION Technological approaches such as telehealth can be a viable alternative in home care service during times of pandemic. We expect that older people with dementia and their caregivers have high adherence to the telehealth program and improve their functional capacity, mental health and quality of life of older people with dementia. Telehealth is an alternative that can contribute to public policies and the development of effective intervention strategies that neutralize adverse outcomes. It can also be presented as an alternative to home care services, which could reduce demands for health resources.