Miracle-dz/UniFAR-FTUs huggingface dataset:
The Implications of Double Human Chorionic Gonadotropin (hCG) Trigger on a Pseudo-Empty Follicle Syndrome Patient Seeking Infertility Treatment Through Assisted Reproductive Technology (ART)

In the field of assisted reproductive technology (ART), empty follicle syndrome (EFS) is a known condition in which no oocytes are found despite adequate follicular development, which leads to a troublesome situation for patients seeking infertility treatment. In this case study, an EFS patient seeking treatment for infertility at an in vitro fertilization (IVF) clinic was examined to determine the effects of employing a double human chorionic gonadotropin (hCG) trigger. The final oocyte maturation and retrieval are induced by using the double hCG trigger, which includes giving two doses of hCG. In this particular patient, the study looks at the results of follicular development, oocyte retrieval, fertilization rates, embryo quality, and pregnancy rates. The conclusion provides information on how well the double hCG trigger affects treatment outcomes for EFS patients. According to the results of this case study, the two-stage hCG trigger procedure is suggested to enhance the results of oocyte retrieval in the uncategorized EFS patient. In all cycles after the procedural change, the double trigger's application led to effective oocyte maturation and retrieval. The study also showed that the double hCG trigger procedure had no negative consequences on patient safety or ovarian response. There were also no signs of ovarian hyperstimulation syndrome (OHSS) or any other problems. Due to the higher likelihood of oocyte retrieval, the patient also reported better emotional health and less anxiety during subsequent treatment cycles. The positive result of this case study demonstrates the potential advantages of a double hCG trigger procedure in pseudo-EFS patients receiving IVF treatment. When handling EFS cases, this modified strategy may be used as a potential answer by infertility clinics. The effectiveness and safety of the double hCG trigger procedure still need to be confirmed by doing randomized controlled trials on larger populations in order to validate the result.
Identification of specific codon 201 mutation of the DCC Gene in the colonoscopic specimen of colorectal cancer.

Objective To identify the mutation in codon 201 of the deleted in colorectal cancer gene in colorectal cancer, and to correlate that mutation to the histopathological grading of colorectal cancer. METHODS The cross-sectional study was conducted from February 2019 to February 2021 after approval from the ethics review board of the Dow University of Health Sciences, Karachi, and comprised biopsy-proven colorectal cancer patients regardless of age and gender. After histopathological reporting, formalin-fixed paraffin-embedded tissue blocks of colorectal cancer were used for deoxyribonucleic acid extraction, followed by polymerase chain reaction optimisation and deoxyribonucleic acid Sanger sequencing for mutational analysis. Data was analysed using SPSS 25. RESULTS Of the 100 biopsy specimens assessed, 45(45%) were selected. Of them, 13(29%) samples failed to show any band on gel electrophoresis. The remaining 32(71%) samples were used for Sanger sequencing. Of these, 1(3%) sample did not sequence, while 31(97%) showed sequencing. All the sequenced samples identified a mutation in codon 201 of exon 3 in the deleted in colorectal cancer gene; 30(97%) showed homozygosity, and 1(3%) showed heterozygosity. No significant association of point mutation was noted with various demographic and clinicopathological parameters (p>0.05). Conclusion The deleted in colorectal cancer gene's missense mutation in codon 201 was frequently observed in colorectal cancer patients.
Soluble Angiotensin-Converting Enzyme 2 Protein Improves Survival and Lowers Viral Titers in Lethal Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection with the Delta Variant

Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) utilizes angiotensin-converting enzyme 2 (ACE2) as its main receptor for cell entry. We bioengineered a soluble ACE2 protein termed ACE2 618-DDC-ABD that has increased binding to SARS-CoV-2 and prolonged duration of action. Here, we investigated the protective effect of this protein when administered intranasally to k18-hACE2 mice infected with the aggressive SARS-CoV-2 Delta variant. k18-hACE2 mice were infected with the SARS-CoV-2 Delta variant by inoculation of a lethal dose (2 × 104 PFU). ACE2 618-DDC-ABD (10 mg/kg) or PBS was administered intranasally six hours prior and 24 and 48 h post-viral inoculation. All animals in the PBS control group succumbed to the disease on day seven post-infection (0% survival), whereas, in contrast, there was only one casualty in the group that received ACE2 618-DDC-ABD (90% survival). Mice in the ACE2 618-DDC-ABD group had minimal disease as assessed using a clinical score and stable weight, and both brain and lung viral titers were markedly reduced. These findings demonstrate the efficacy of a bioengineered soluble ACE2 decoy with an extended duration of action in protecting against the aggressive Delta SARS-CoV-2 variant. Together with previous work, these findings underline the universal protective potential against current and future emerging SARS-CoV-2 variants.
A Novel Dimeric Melampolide and Further Terpenoids from Smallanthus sonchifolius (Asteraceae) and the Inhibition of the Transcription Factor NF-κB

A novel dimeric melampolide was isolated from the leaf rinse extract of Smallanthus sonchifolius (Poepp. & Endl.) H. Robinson (Asteraceae), an Andean medicinal plant popularly known as yacón. Dimeric sesquiterpene lactones are rare in Asteraceae, especially melampolides. In addition, eight known melampolides and a new ester derivative were also isolated. All compounds were detected in glandular trichomes collected from the leaves and were analysed by HPLC. The anti-inflammatory properties of uvedalin, a known melampolide isolated in this study, were assessed in vitro by analyzing its effect on the DNA binding of the transcription factor NF-κB. These results were compared to those previously reported for the closely related melampolide enhydrin. Our data demonstrated that NF-κB DNA binding was inhibited in leukaemia and macrophage cells at an uvedalin concentration of 2.5 and 5 μM, respectively.
State of the Art of finite GMM Based Biometrics Face Authentication Systems

This paper presents a comparative analysis of the performance of three estimation algorithms: Expectation Maximization (EM), Greedy EM Algorithm (GEM) and Figueiredo-Jain Algorithm (FJ) - based on the Gaussian mixture models (GMMs) for a Dynamic Biometrics Face Authentication Systems. An automated biometric systems for human identification measure a “signature” of the human body, compare the resulting characteristic to a database, and render an application dependent decision. A Dynamic Face From eNTERFACE 2005 Database is used and Simulation shows that finite mixture modal (GMM) is quite effective in modelling the genuine and impostor score densities. Hence, the still face information scheme based on dynamic biometrics face is robust and could be explored for identity authentication
An Ecosystem Services Approach to Assessing the Impacts of the Deepwater Horizon Oil Spill in the Gulf of Mexico

As the Gulf of Mexico recovers from the Deepwater Horizon oil spill, natural resource managers face the challenge of understanding the impacts of the spill and setting priorities for restoration work. The full value of losses resulting from the spill cannot be captured, however, without consideration of changes in ecosystem services--the benefits delivered to society through natural processes. An Ecosystem Services Approach to Assessing the Impacts of the Deepwater Horizon Oil Spill in the Gulf of Mexico discusses the benefits and challenges associated with using an ecosystem services approach to damage assessment, describing potential impacts of response technologies, exploring the role of resilience, and offering suggestions for areas of future research. This report illustrates how this approach might be applied to coastal wetlands, fisheries, marine mammals, and the deep sea -each of which provide key ecosystem services in the Gulf -and identifies substantial differences among these case studies. The report also discusses the suite of technologies used in the spill response, including burning, skimming, and chemical dispersants, and their possible long-term impacts on ecosystem services.
A Unique Collection of Palaeolithic Painted Portable Art: Characterization of Red and Yellow Pigments from the Parpalló Cave (Spain)

In this work we analyze the pigments used in the decoration of red and yellow motifs present in the portable art of the Parpalló Cave (Gandía, Spain), one of the most important Palaeolithic sites in the Spanish Mediterranean region. Energy dispersive X-ray fluorescence spectrometry (EDXRF) and spectrophotometry in the visible region (CIEL*a*b*color coordinates and spectral reflectance curves) were used to perform in situ fast analyses of the red and yellow motifs with portable equipment and to characterize their elemental composition and their colorimetric perception, respectively. According to the elemental composition, the intensity of the fluorescence iron signals in red and yellow motifs are higher than average values in the rock substrates. As expected, red motifs possess high values of the chromatic coordinate a* and yellow motifs possess high values of b*. This characterization was complemented with FT-IR analyses of microsamples detached from the red and yellow colored zones of a small set of plaquettes. Our results show that the artists used red and yellow pigments in the decoration likely derived from natural iron oxides as hematite and goethite.
Design and Simulation of a System-in-Package Chip for Combined Navigation

This paper proposes a system-in-package combination navigation chip. We used wire bonding, chip stacking, surface mount, and other processes to integrate satellite navigation chips, inertial navigation chips, microprocessor chips, and separation devices. Finally, we realized the hardware requirements for combined navigation in a 20 mm × 20 mm chip. Further, we performed a multi-physics simulation analysis of the package design. For antenna signals, the insertion loss was greater than −1 dB@1 GHz and the return loss was less than −10 dB@1 GHz. The amplitude of these noises of the signal between the MCU and the IMU was approximately 20%, and the maximum value of the coupling coefficient between signal lines on the top surface was 13.4174%. The ninth mode of the power plane yielded a maximum voltage of 55 mV, and all power delivery networks had a DC voltage drop of less than 2%. The highest temperature in the microsystem was approximately 42 °C. These results show that our design performed well in terms of signal, power, and thermal performance.
Self-Cleaning Highly Porous TiO2 Coating Designed by Swelling-Assisted Sequential Infiltration Synthesis (SIS) of a Block Copolymer Template

Photocatalytic self-cleaning coatings with a high surface area are important for a wide range of applications, including optical coatings, solar panels, mirrors, etc. Here, we designed a highly porous TiO2 coating with photoinduced self-cleaning characteristics and very high hydrophilicity. This was achieved using the swelling-assisted sequential infiltration synthesis (SIS) of a block copolymer (BCP) template, which was followed by polymer removal via oxidative thermal annealing. The quartz crystal microbalance (QCM) was employed to optimize the infiltration process by estimating the mass of material infiltrated into the polymer template as a function of the number of SIS cycles. This adopted swelling-assisted SIS approach resulted in a smooth uniform TiO2 film with an interconnected network of pores. The synthesized film exhibited good crystallinity in the anatase phase. The resulting nanoporous TiO2 coatings were tested for their functional characteristics. Exposure to UV irradiation for 1 h induced an improvement in the hydrophilicity of coatings with wetting angle reducing to unmeasurable values upon contact with water droplets. Furthermore, their self-cleaning characteristics were tested by measuring the photocatalytic degradation of methylene blue (MB). The synthesized porous TiO2 nanostructures displayed promising photocatalytic activity, demonstrating the degradation of approximately 92% of MB after 180 min under ultraviolet (UV) light irradiation. Thus, the level of performance was comparable to the photoactivity of commercial anatase TiO2 nanoparticles of the same quantity. Our results highlight a new robust approach for designing hydrophilic self-cleaning coatings with controlled porosity and composition.
Augmented Reality Creation Platform Based on Graphical Programming

The development of conventional augmented reality (AR) works typically involves complex environment setup, programming development, high costs, and long development cycles, requiring developers to possess certain technical expertise and facing a high entry barrier. To address these challenges and reduce the difficulty of AR work development, this paper proposes a method for creating AR works based on graphical programming. A prototype system is developed to facilitate visual creation. The proposed method involves importing models and AR markers to construct the elements of the work. Subsequently, model parameter variables are designed to enable graphical programming and establish data associations between the work’s elements and the logic function algorithm. Additionally, the front-end page layout of the work can be conducted, and the binding of front-end buttons to back-end graphical programming trigger events can be realized. The prototype system is developed using the AR-Foundation and Unity3D engine. Several case studies are presented to demonstrate the feasibility and versatility of this AR creation method.
Single-PCB Fabricated, Ultrawideband, and Wide-Scanning Phased Array Antenna With Vertically Integrated Resistive Frequency-Selective Surface

A novel ultrawideband phased array antenna that vertically integrates a resistive frequency-selective surface (FSS) is proposed to achieve a bandwidth ratio of 15:1. This antenna operates from 0.8 to 12 GHz and is designed to be fabricated on a single printed circuit board (PCB). The active voltage standing wave ratio (VSWR) for the infinite array is lower than 3.2 at broadside. It remains lower than 2.9, 3.3, and 4.3 when scanning to 60° in E-plane, D-plane, and H-plane, respectively. At first, the tightly coupled dipole with the vertically integrated resistive FSS (RFSS) and the overlapping pad is designed to mitigate the short-circuited effect and cancel the reactance of the nearby ground plane, respectively. Then, the shorted posts are added to mitigate the non-radiating common mode, which also introduces the radiating loop mode into the proposed antenna. However, the central resonant frequency of the loop mode is far from the operating frequency bands. To address this issue, the cavity-backed overlapping pad is designed to change the loop path. By adjusting the position of the shorted posts, the central resonant frequency of this loop mode is moved to around 2 GHz. Moreover, to lower the active VSWR when scanning and then improve the radiation efficiency, the wide-scanning impedance matching FSS and the double-layer RFSS with the modified structures are employed. Finally, a $17\times17$ array prototype is built and measured to verify these designs.
Ekstraksi Informasi 5W1H pada Berita Online Bahasa Indonesia

Pertumbuhan portal berita berdampak pada melimpahya informasi. Banyaknya informasi menimbulkan persoalan kesulitan pencarian informasi yang dibutuhkan karena informasi penting tertutup oleh informasi yang tidak dibutuhkan. Untuk mendapatkan informasi utama (5W1H), diperlukan sistem yang mampu mengekstraksi informasi dari berita secara otomatis. Pada penelitian ini, Ekstraksi Informasi digunakan dengan pendekatan pembelajaran mesin. Model terbaik didapatkan dengan menggunakan 16 fitur, SMOTE ( Synthetic Minority Over-sampling ), dan algoritma IBk ( Instance-based Learning ). Hasil pengukurannya F-measure 10-fold cross validation 0.995, hasil tes dengan fitur window kelas ( bef-one- kelas dan bef-two- kelas) otomatis 0.948, dan hasil dengan 10 cluster data tes berita 0.377. Penelitian ektraksi 5W1H pada berita masih perlu dikembangkan untuk mendapatkan kinerja terbaik. Kata Kunci Ekstraksi Informasi, 5W1H, Berita Online , Pembelajaran Mesin, IBk, SMOTE
Especificando Comportamentos para Futebol de Robôs da Abordagem DDM

O futebol de robôs é frequentemente utilizado como berço de teste para Sistemas Multi Agentes (SMA). Em um time de futebol, cada jogador é um agente, e suas ações precisam estar coordenadas com outros agentes para alcançar um objetivo. Neste contexto, planos coordenados, denominados setplays, são utilizados para simular e planejar situações reais do jogo. Ferramentas para definir setplays geralmente possuem um conjunto limitado de comportamentos disponíveis para uso, ex. chutar, e novos comportamentos precisam ser codificados manualmente. Este trabalho propõe uma solução para apoiar a implementação de comportamentos para simulação e execução de SMAs cooperativos, no contexto de futebol de robôs. A solução utiliza o Desenvolvimento Dirigido a Modelos (DDM), que permite a definição de comportamentos em alto nível de abstração e subsequente transformação (semi) automática em código-fonte para ferramentas específicas. Experimentos com times de futebol de robôs demonstraram a viabilidade da solução na definição de comportamentos e geração de código-fonte para as ferramentas FCPortugal Framework e SPlanner utilizadas por diversos times de futebol de robôs.
A Sub-THz Full-Duplex Phased-Array Transceiver With Self-Interference Cancellation and LO Feedthrough Suppression

A sub-THz (88–136 GHz) full-duplex (FD) phased-array transceiver (TRX) integrating an RF self-interference (SI) canceller with differential feeding FD antennas is presented in this work. The LO phase generation chain controls differential transmitter outputs for the phased-array operation. The differential feeding FD antenna with differential pairs of chips achieves over 35-dB SI suppression. The SI suppression is improved by 20 dB when the SI canceller is turned on. Without any digital-domain SI cancellation (SIC), a total SI suppression of >60 dB is achieved over a 2-GHz bandwidth. The proposed neutralized mixer with over 20-dB LO feedthrough suppression and wideband RF amplifiers support a large data rate at sub-THz frequencies. This is the world’s first demonstrated sub-THz FD phased-array TRX. In the over-the-air (OTA) measurements for FD mode, the proposed FD TRX achieves 6 Gb/s in 8PSK and 4 Gb/s in 16QAM. It also achieves a 112-Gb/s data rate for OTA TX-to-RX.
Circa situm Conservation of Tree Genetic Resources: A Case Study from the Central Western Ghats of Karnataka, India

Tree species are an integral part of agrobiodiversity. Several tree species have multifarious uses. India’s Western Ghats, with diverse climate, topography and soils, are home to a number of tree species. A study was conducted in the adjoining areas of Karnataka’s Central Western Ghats, including coastal lowlands/plains (Dakshina Kannada) and high mountain ranges (Shivamogga and Uttara Kannada). A total of 93 species belonging to 75 genera and 41 families are being conserved circa situm by the farmers of this region. From our study, it was found that the conservation of tree species solely depends on the farmers’ perception of the utilization of these species i.e., “conservation through use” and the species recorded in the present study area are conserved due to their uses as timber, fruit/nut/spice/ornamental, border/windbreaker, fuel, cultural significance, shade and other uses (gum, resin, soil conservation, etc.). Conservation through circa situm recognizes the ownership of the farmers of a given region and also considers the socio-economic context of conservation by meeting the food, nutrition, livelihood and income security of the farmers
The Role of Bacillus Subtilis Bacteria on The Growth and Production of Two Varieties of Shallots (Allium Ascalonicum L.) Asal True Shallot Seed

Increasing the production of shallots from True shallot seed (TSS) can be done using Bacillus subtilis bacteria. This study aims to determine the role of Bacillus subtilis bacteria on the growth and production of two shallot varieties (Allium ascalonicum L.) from True Sallot Seed. This research was conducted on Jl. Bandar Meriah, Sukamaju village, Sunggal sub-district, Deli Serdang district, with a height of 30 MDPL. This research was conducted from December 2022 to March 2023. This study used a randomised block design with two factors and three replications. The first factor is a variety of types: Sanren F-1 and Lokananta. The second factor was Bacillus subtilis bacteria with four levels: 0 ml/tanaman, 5 ml/plant, 10 ml/plant, and 15 ml/plant. The results showed that the Lokananta variety had plant heights of 5 and 7 MSPT, number of leaves 4-7 MSPT, chlorophyll B, total chlorophyll, fresh tuber weight per sample, fresh tuber weight per plot, dry tuber weight per sample and dry tuber weight per plot, Which is higher than the Sanren F-1 variety. Giving 15 ml of Bacillus subtilis bacteria/plant has tuber circumference, number of tubers per plot, weight of fresh tubers per plot, weight of dry tubers per sample, weight of dry tubers per plot, which is higher than giving bacteria of 0 ml/plant, 5 ml/plant and 10 ml/plant.
Impact of hypertension, smoking and liver affection on endothelial dysfunction and subsequent vascular damage in Saudi middle aged males

Endothelial dysfunction is one of the mechanisms linked to an increased risk of cardiovascular disease. To assess the impact of hypertension, smoking and past history of schistosomiasis on endothelial dysfunction and vascular damage in Saudi middle aged males who don't exercise regularly, the levels of soluble adhesion molecules E-selectin, ICAM-1 and VCAM-1, biomarkers of the activation of inflammatory cascades during the development of vascular injury, were determined. Plasma levels of sVCAM-1, sICAM-1 and sE-selectin were found to be elevated as a result of hypertension and/or cigarette smoking compared to normal counterparts. These results demonstrated that hypertension and cigarette smoking had the strongest direct associations with these biomarkers which are a reflection of their effect on endothelial dysfunction and subsequent vascular damage, while a past history of schistosomiasis had very little association with these biomarkers. These results also suggest that sVCAM-1 may be useful in assessing the impact of liver affliction, (as a result of schistosomiasis) on endothelial dysfunction.
Case report: Diagnosis of NUT carcinoma of hepatic origin by next-generation sequencing

NUT carcinoma is a rare subcategory of squamous cell carcinoma. The latter is primarily characterized by the fusion of the coding sequence NUTM1 on chromosome 15q14 with BRD4 or BRD3, both of which are acetyl-histone binding bromodomains. This tumor is often misdiagnosed due to its rarity and its histological similarity with other squamous cell carcinomas. It typically presents as a poorly differentiated squamous cell carcinoma in the head, neck, and mediastinal region, and has no distinct clinical characteristics that set it apart from other malignancies. Although uncommon, other NUT carcinomas have been reported in the literature outside of the midline region. Through next-generation sequencing, we were able to correctly diagnose our patient with the first-documented case of NUT carcinoma of hepatic-only origin.